BLASTP 2.2.22 [Sep-27-2009]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.


Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.


Reference for composition-based statistics starting in round 2:
Schaffer, Alejandro A., L. Aravind, Thomas L. Madden,
Sergei Shavirin, John L. Spouge, Yuri I. Wolf,  
Eugene V. Koonin, and Stephen F. Altschul (2001), 
"Improving the accuracy of PSI-BLAST protein database searches with 
composition-based statistics and other refinements",  Nucleic Acids Res. 29:2994-3005.

Query= batch____
         (260 letters)

Database: uniref50.fasta 
           3,077,464 sequences; 1,040,396,356 total letters

Searching..................................................done


Results from round 1


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

UniRef50_Q47417 tRNA pseudouridine synthase C n=252 Tax=cellular...   387   e-106
UniRef50_Q8DBG5 tRNA pseudouridine synthase C n=54 Tax=Gammaprot...   299   6e-80
UniRef50_B8CQ92 Pseudouridine synthase n=1 Tax=Shewanella piezot...   265   9e-70
UniRef50_Q15QZ8 Pseudouridine synthase n=5 Tax=Bacteria RepID=Q1...   259   6e-68
UniRef50_Q30SZ1 Pseudouridine synthase n=2 Tax=Proteobacteria Re...   258   2e-67
UniRef50_C8PZW5 Pseudouridine synthase n=1 Tax=Enhydrobacter aer...   256   8e-67
UniRef50_UPI0001AEC02F pseudouridylate synthase, 23S RNA-specifi...   249   6e-65
UniRef50_C5TPY8 Pseudouridine synthase n=6 Tax=Proteobacteria Re...   249   7e-65
UniRef50_Q39Z12 Pseudouridine synthase n=3 Tax=Proteobacteria Re...   242   1e-62
UniRef50_B4RVP9 Pseudouridine synthase n=1 Tax=Alteromonas macle...   242   1e-62
UniRef50_B5JL25 Pseudouridine synthase n=1 Tax=Verrucomicrobiae ...   237   3e-61
UniRef50_Q31IZ8 Pseudouridine synthase n=2 Tax=Proteobacteria Re...   229   1e-58
UniRef50_C4KBT4 Transaldolase n=2 Tax=Proteobacteria RepID=C4KBT...   226   4e-58
UniRef50_A1K5H7 Pseudouridine synthase n=5 Tax=Proteobacteria Re...   226   7e-58
UniRef50_Q47Y03 Pseudouridine synthase n=1 Tax=Colwellia psychre...   223   4e-57
UniRef50_A1U2H1 Pseudouridine synthase n=1 Tax=Marinobacter aqua...   221   1e-56
UniRef50_D2QPA6 Pseudouridine synthase n=1 Tax=Spirosoma lingual...   215   9e-55
UniRef50_Q1N5G6 Pseudouridine synthase n=1 Tax=Bermanella marisr...   213   4e-54
UniRef50_A4BJ00 Pseudouridine synthase n=1 Tax=Reinekea blandens...   213   7e-54
UniRef50_C0Q9S8 TruC n=1 Tax=Desulfobacterium autotrophicum HRM2...   208   1e-52
UniRef50_A9BZ16 Pseudouridine synthase n=9 Tax=Burkholderiales R...   207   4e-52
UniRef50_C6VVP1 Pseudouridine synthase n=4 Tax=Bacteroidetes Rep...   205   1e-51
UniRef50_Q1QTG8 Pseudouridine synthase n=2 Tax=Gammaproteobacter...   199   8e-50
UniRef50_A6VXE8 Pseudouridine synthase n=2 Tax=Marinomonas RepID...   197   2e-49
UniRef50_A1WTN6 Pseudouridine synthase n=2 Tax=Ectothiorhodospir...   195   1e-48
UniRef50_A3HSB5 Pseudouridine synthase n=1 Tax=Algoriphagus sp. ...   195   1e-48
UniRef50_A6DMG7 tRNA pseudouridine synthase n=1 Tax=Lentisphaera...   189   1e-46
UniRef50_C7LP91 Pseudouridine synthase n=1 Tax=Desulfomicrobium ...   188   1e-46
UniRef50_Q6MMV3 Pseudouridine synthase n=2 Tax=Bdellovibrio bact...   177   3e-43
UniRef50_B0RLZ1 Pseudouridine synthase n=13 Tax=Xanthomonadaceae...   176   9e-43
UniRef50_A2U235 Pseudouridine synthase n=3 Tax=Flavobacteriaceae...   168   2e-40
UniRef50_A9GEI0 Pseudouridine synthase n=2 Tax=Myxococcales RepI...   152   1e-35
UniRef50_B7RZ07 Putative uncharacterized protein n=1 Tax=marine ...   135   2e-30
UniRef50_A9B3Z2 Pseudouridine synthase n=1 Tax=Herpetosiphon aur...   133   6e-30
UniRef50_Q9KQH0 Ribosomal large subunit pseudouridine synthase C...   119   1e-25
UniRef50_Q3JQ55 Pseudouridine synthase n=170 Tax=cellular organi...   117   3e-25
UniRef50_A0L8J2 Pseudouridine synthase n=1 Tax=Magnetococcus sp....   116   6e-25
UniRef50_Q5QZ45 Pseudouridine synthase n=2 Tax=Gammaproteobacter...   114   4e-24
UniRef50_C9M5C8 Pseudouridine synthase n=1 Tax=Jonquetella anthr...   113   8e-24
UniRef50_A1AVB5 Pseudouridine synthase n=2 Tax=sulfur-oxidizing ...   112   9e-24
UniRef50_B0VCN8 Pseudouridine synthase n=16 Tax=Acinetobacter Re...   112   1e-23
UniRef50_A9GIV4 Pseudouridine synthase n=1 Tax=Sorangium cellulo...   112   2e-23
UniRef50_A7H6D3 Pseudouridine synthase n=6 Tax=Cystobacterineae ...   111   3e-23
UniRef50_Q8ZQ16 Ribosomal large subunit pseudouridine synthase C...   111   3e-23
UniRef50_C7LVL1 Pseudouridine synthase n=5 Tax=Proteobacteria Re...   110   3e-23
UniRef50_B6G997 Pseudouridine synthase n=1 Tax=Collinsella sterc...   110   3e-23
UniRef50_A7HL94 Pseudouridine synthase n=2 Tax=Thermotogaceae Re...   110   5e-23
UniRef50_B5YAZ5 Pseudouridine synthase n=2 Tax=Dictyoglomus RepI...   110   5e-23
UniRef50_B1H073 Ribosomal large subunit pseudouridine synthase C...   110   6e-23
UniRef50_Q89AH2 Ribosomal large subunit pseudouridine synthase C...   110   7e-23
UniRef50_Q1DCE5 Pseudouridine synthase, RluA family n=2 Tax=Cyst...   109   1e-22
UniRef50_C4FYR8 Pseudouridine synthase n=1 Tax=Abiotrophia defec...   109   1e-22
UniRef50_Q0F3G4 Pseudouridine synthase n=1 Tax=Mariprofundus fer...   108   1e-22
UniRef50_D1Y726 Ribosomal large subunit pseudouridine synthase D...   108   1e-22
UniRef50_B7G0Q3 Predicted protein (Fragment) n=1 Tax=Phaeodactyl...   108   1e-22
UniRef50_Q492Q1 Pseudouridine synthase n=2 Tax=Candidatus Blochm...   108   1e-22
UniRef50_C0N6T7 Pseudouridine synthase n=1 Tax=Methylophaga thio...   108   2e-22
UniRef50_B8FLB4 Pseudouridine synthase n=2 Tax=Bacteria RepID=B8...   108   2e-22
UniRef50_Q1ILA4 Pseudouridine synthase n=1 Tax=Candidatus Koriba...   107   4e-22
UniRef50_B0TGQ0 Pseudouridine synthase n=44 Tax=Bacteria RepID=B...   107   4e-22
UniRef50_B0N6U2 Pseudouridine synthase n=5 Tax=Bacteria RepID=B0...   107   4e-22
UniRef50_A0LXI9 Pseudouridine synthase n=1 Tax=Gramella forsetii...   106   7e-22
UniRef50_Q6MND5 Pseudouridine synthase n=1 Tax=Bdellovibrio bact...   106   8e-22
UniRef50_A6GP31 Pseudouridine synthase n=1 Tax=Limnobacter sp. M...   106   8e-22
UniRef50_C8PTH9 Ribosomal large subunit pseudouridine synthase C...   106   9e-22
UniRef50_Q8ZFU1 Ribosomal large subunit pseudouridine synthase C...   106   9e-22
UniRef50_A3Y8C6 Pseudouridine synthase n=1 Tax=Marinomonas sp. M...   105   1e-21
UniRef50_A9E330 Pseudouridine synthase n=1 Tax=Kordia algicida O...   105   1e-21
UniRef50_D0P480 Ribosomal large subunit pseudouridine synthase A...   105   1e-21
UniRef50_B7FU02 Predicted protein (Fragment) n=1 Tax=Phaeodactyl...   105   1e-21
UniRef50_C8NEP8 Pseudouridine synthase n=1 Tax=Granulicatella ad...   105   1e-21
UniRef50_D1W0M0 Pseudouridine synthase n=1 Tax=Prevotella timone...   105   2e-21
UniRef50_B9Y836 Pseudouridine synthase n=3 Tax=Firmicutes RepID=...   105   2e-21
UniRef50_Q126H9 Pseudouridine synthase n=1 Tax=Polaromonas sp. J...   104   3e-21
UniRef50_Q6FCX9 Pseudouridine synthase n=1 Tax=Acinetobacter sp....   104   3e-21
UniRef50_Q1J0S8 Pseudouridine synthase n=7 Tax=Deinococci RepID=...   104   3e-21
UniRef50_P44433 Ribosomal large subunit pseudouridine synthase C...   104   3e-21
UniRef50_D2RBY1 Pseudouridine synthase, RluA family n=1 Tax=Gard...   104   3e-21
UniRef50_Q73K15 RNA pseudouridylate synthase family protein n=1 ...   104   4e-21
UniRef50_Q1PXB6 Pseudouridine synthase n=1 Tax=Candidatus Kuenen...   103   5e-21
UniRef50_C8PQT2 Ribosomal large subunit pseudouridine synthase D...   103   5e-21
UniRef50_Q0AFD5 Pseudouridine synthase n=3 Tax=Nitrosomonas RepI...   103   5e-21
UniRef50_D2R4N0 Pseudouridine synthase, RluA family n=1 Tax=Pire...   103   5e-21
UniRef50_A6LDZ7 Pseudouridine synthase n=26 Tax=Bacteroidales Re...   103   5e-21
UniRef50_D2R7T3 Pseudouridine synthase, RluA family n=1 Tax=Pire...   103   6e-21
UniRef50_A6NQQ9 Pseudouridine synthase n=1 Tax=Bacteroides capil...   103   8e-21
UniRef50_C5S931 Pseudouridine synthase n=2 Tax=Gammaproteobacter...   103   8e-21
UniRef50_Q489H0 Pseudouridine synthase n=3 Tax=Gammaproteobacter...   102   9e-21
UniRef50_B8DF66 Pseudouridine synthase n=18 Tax=Listeria RepID=B...   102   9e-21
UniRef50_D2QJH0 Pseudouridine synthase, RluA family n=3 Tax=Bact...   102   9e-21
UniRef50_A3MZ33 Pseudouridine synthase n=9 Tax=Proteobacteria Re...   102   1e-20
UniRef50_Q6MEZ4 Pseudouridine synthase n=1 Tax=Candidatus Protoc...   102   1e-20
UniRef50_A6ESW1 Pseudouridine synthase n=1 Tax=unidentified euba...   102   1e-20
UniRef50_C1F7V3 Pseudouridine synthase n=1 Tax=Acidobacterium ca...   102   1e-20
UniRef50_A9NGF1 Pseudouridine synthase n=1 Tax=Acholeplasma laid...   102   1e-20
UniRef50_D0MK65 Pseudouridine synthase n=1 Tax=Rhodothermus mari...   102   1e-20
UniRef50_B7GLK3 Pseudouridine synthase n=11 Tax=Bacillaceae RepI...   102   2e-20
UniRef50_A5IZB6 Pseudouridine synthase n=4 Tax=Mycoplasma RepID=...   102   2e-20
UniRef50_A9RVX3 Predicted protein n=1 Tax=Physcomitrella patens ...   102   2e-20
UniRef50_P0AA37 Ribosomal large subunit pseudouridine synthase A...   102   2e-20
UniRef50_P50513 Ribosomal large subunit pseudouridine synthase D...   101   2e-20
UniRef50_Q87AR7 Ribosomal large subunit pseudouridine synthase D...   101   2e-20
UniRef50_A6NVX8 Pseudouridine synthase n=1 Tax=Bacteroides capil...   101   2e-20
UniRef50_C1ZMP6 Pseudouridine synthase n=1 Tax=Planctomyces limn...   101   2e-20
UniRef50_Q30NR3 Pseudouridine synthase n=1 Tax=Sulfurimonas deni...   101   2e-20
UniRef50_Q0VQN9 Pseudouridine synthase n=2 Tax=Alcanivorax RepID...   101   3e-20
UniRef50_Q7MA82 Pseudouridine synthase n=1 Tax=Wolinella succino...   100   3e-20
UniRef50_UPI0001C36F41 hypothetical protein RflaF_04377 n=1 Tax=...   100   3e-20
UniRef50_B2S2H8 Pseudouridine synthase n=2 Tax=Treponema pallidu...   100   4e-20
UniRef50_Q1MQ60 Pseudouridylate synthases, 23S RNA-specific n=1 ...   100   4e-20
UniRef50_C7NAV5 Pseudouridine synthase n=5 Tax=Fusobacteriaceae ...   100   4e-20
UniRef50_A6Q113 Pseudouridine synthase n=1 Tax=Nitratiruptor sp....   100   5e-20
UniRef50_A6LIG6 Pseudouridine synthase n=5 Tax=Bacteroidales Rep...   100   5e-20
UniRef50_Q3YSF8 Pseudouridine synthase n=5 Tax=canis group RepID...   100   5e-20
UniRef50_Q3ABZ7 Pseudouridine synthase n=2 Tax=Bacteria RepID=Q3...   100   5e-20
UniRef50_B6BGX6 Pseudouridine synthase n=1 Tax=Campylobacterales...   100   5e-20
UniRef50_B0VJ94 Pseudouridine synthase n=1 Tax=Candidatus Cloaca...   100   7e-20
UniRef50_UPI00016C40E0 pseudouridine synthase n=1 Tax=Gemmata ob...   100   7e-20
UniRef50_D1AV01 Pseudouridine synthase n=2 Tax=Bacteria RepID=D1...   100   8e-20
UniRef50_D0L1K7 Pseudouridine synthase n=1 Tax=Halothiobacillus ...   100   8e-20
UniRef50_B1Y046 Pseudouridine synthase n=43 Tax=Proteobacteria R...   100   8e-20
UniRef50_B8FT16 Pseudouridine synthase n=70 Tax=Bacteria RepID=B...   100   9e-20
UniRef50_B1I3F8 Pseudouridine synthase n=2 Tax=Bacteria RepID=B1...   100   9e-20
UniRef50_Q0A8Q9 Pseudouridine synthase n=4 Tax=Ectothiorhodospir...   100   9e-20
UniRef50_Q45826 Uncharacterized RNA pseudouridine synthase Caur_...    99   1e-19
UniRef50_A9BFW4 Pseudouridine synthase n=8 Tax=Thermotogaceae Re...    99   1e-19
UniRef50_C4V3I7 Pseudouridine synthase n=1 Tax=Selenomonas flueg...    99   1e-19
UniRef50_B1ZRU1 Pseudouridine synthase n=2 Tax=Opitutaceae RepID...    99   1e-19
UniRef50_A6GAA8 Pseudouridine synthase, RluA family protein n=1 ...    99   2e-19
UniRef50_B8CWB7 Pseudouridine synthase n=1 Tax=Halothermothrix o...    99   2e-19
UniRef50_Q83G23 Pseudouridine synthase n=2 Tax=Tropheryma whippl...    99   2e-19
UniRef50_Q7NBQ4 Pseudouridine synthase n=1 Tax=Mycoplasma gallis...    99   2e-19
UniRef50_C0R043 Pseudouridine synthase n=2 Tax=Brachyspira RepID...    98   3e-19
UniRef50_D0XS67 Pseudouridine synthase n=1 Tax=Brevundimonas sub...    98   3e-19
UniRef50_C1ZGS9 Pseudouridine synthase n=1 Tax=Planctomyces limn...    98   3e-19
UniRef50_C0GNZ6 Pseudouridine synthase, RluA family n=1 Tax=Desu...    98   3e-19
UniRef50_Q2NIN6 Pseudouridine synthase n=4 Tax=Candidatus Phytop...    98   3e-19
UniRef50_Q03WF6 Pseudouridine synthase n=9 Tax=Firmicutes RepID=...    98   3e-19
UniRef50_B8FTI5 Pseudouridine synthase n=2 Tax=Desulfitobacteriu...    98   3e-19
UniRef50_Q12L72 Pseudouridine synthase n=17 Tax=Shewanella RepID...    98   3e-19
UniRef50_C6E472 Pseudouridine synthase n=4 Tax=Geobacter RepID=C...    97   4e-19
UniRef50_A7ZDY2 Pseudouridine synthase n=4 Tax=Epsilonproteobact...    97   4e-19
UniRef50_C6BRU5 Pseudouridine synthase n=1 Tax=Desulfovibrio sal...    97   5e-19
UniRef50_A3EQJ0 Pseudouridine synthase n=1 Tax=Leptospirillum ru...    97   5e-19
UniRef50_C9RKF9 Pseudouridine synthase n=1 Tax=Fibrobacter succi...    97   5e-19
UniRef50_B5YKV0 Pseudouridine synthase n=1 Tax=Thermodesulfovibr...    97   6e-19
UniRef50_B7BE87 Pseudouridine synthase n=8 Tax=Bacteroidales Rep...    97   6e-19
UniRef50_A6VZC6 Pseudouridine synthase n=2 Tax=Marinomonas RepID...    97   6e-19
UniRef50_C0FY60 Pseudouridine synthase n=1 Tax=Roseburia inulini...    97   6e-19
UniRef50_A9BWX6 Pseudouridine synthase n=2 Tax=Comamonadaceae Re...    97   6e-19
UniRef50_B7GAM3 Predicted protein (Fragment) n=1 Tax=Phaeodactyl...    97   7e-19
UniRef50_C0F0M1 Putative uncharacterized protein n=1 Tax=Eubacte...    97   7e-19
UniRef50_D0BL50 Pseudouridine synthase n=1 Tax=Granulicatella el...    97   7e-19
UniRef50_D1RB93 Pseudouridine synthase n=1 Tax=Parachlamydia aca...    97   7e-19
UniRef50_C9KPZ8 Pseudouridine synthase n=1 Tax=Mitsuokella multa...    96   8e-19
UniRef50_B1VEM5 Pseudouridine synthase n=3 Tax=Corynebacterium R...    96   1e-18
UniRef50_A5INM9 Pseudouridine synthase n=7 Tax=Thermotogaceae Re...    96   1e-18
UniRef50_P54604 Uncharacterized RNA pseudouridine synthase yhcT ...    96   1e-18
UniRef50_C7MES4 Pseudouridine synthase, RluA family n=5 Tax=Acti...    96   1e-18
UniRef50_C8W9Q3 Pseudouridine synthase n=2 Tax=Atopobium RepID=C...    96   1e-18
UniRef50_B6J6C4 Pseudouridine synthase n=7 Tax=Coxiella burnetii...    96   1e-18
UniRef50_Q6MM51 Ribosomal large subunit pseudouridine synthase C...    96   1e-18
UniRef50_Q2SK59 Pseudouridine synthase n=3 Tax=Gammaproteobacter...    96   1e-18
UniRef50_B9XS18 Pseudouridine synthase n=1 Tax=bacterium Ellin51...    96   1e-18
UniRef50_C0MA80 Pseudouridine synthase n=6 Tax=Streptococcus Rep...    96   1e-18
UniRef50_B0JGC2 Pseudouridine synthase n=2 Tax=Microcystis aerug...    96   1e-18
UniRef50_Q67N67 Pseudouridine synthase n=1 Tax=Symbiobacterium t...    96   2e-18
UniRef50_A5EX53 Pseudouridine synthase n=1 Tax=Dichelobacter nod...    96   2e-18
UniRef50_A4ANB8 Pseudouridine synthase n=3 Tax=Flavobacteriales ...    96   2e-18
UniRef50_C1ZB48 Pseudouridine synthase, RluA family n=1 Tax=Plan...    95   2e-18
UniRef50_A9IQ66 Pseudouridine synthase n=5 Tax=Bacteria RepID=A9...    95   2e-18
UniRef50_B6AN83 Pseudouridine synthase n=2 Tax=Leptospirillum Re...    95   2e-18
UniRef50_D1ANU4 Pseudouridine synthase n=14 Tax=Fusobacteriaceae...    95   2e-18
UniRef50_A4CLQ5 Pseudouridine synthase n=16 Tax=Bacteria RepID=A...    95   2e-18
UniRef50_B7HGW1 Pseudouridine synthase n=52 Tax=Bacillales RepID...    95   3e-18
UniRef50_C4GB89 Pseudouridine synthase n=1 Tax=Shuttleworthia sa...    95   3e-18
UniRef50_D1B0V0 Pseudouridine synthase n=1 Tax=Sulfurospirillum ...    95   3e-18
UniRef50_A1HR26 Pseudouridine synthase, RluA family n=1 Tax=Ther...    95   3e-18
UniRef50_Q0BWH2 Pseudouridine synthase n=3 Tax=Alphaproteobacter...    95   3e-18
UniRef50_Q0BUM2 Pseudouridine synthase n=12 Tax=Acetobacteraceae...    94   3e-18
UniRef50_C5BU65 Pseudouridine synthase for 23S rRNA and tRNAphe ...    94   3e-18
UniRef50_Q5E092 Pseudouridine synthase n=3 Tax=Aliivibrio RepID=...    94   4e-18
UniRef50_C0M8E2 Pseudouridine synthase n=3 Tax=Streptococcus equ...    94   4e-18
UniRef50_A5WCP4 Pseudouridine synthase n=15 Tax=Moraxellaceae Re...    94   4e-18
UniRef50_Q3AD19 Ribosomal large subunit pseudouridine synthase, ...    94   4e-18
UniRef50_Q1CZL9 Pseudouridine synthase n=5 Tax=Proteobacteria Re...    94   5e-18
UniRef50_B7GQ28 Pseudouridine synthase, RluA family n=21 Tax=Bif...    94   6e-18
UniRef50_C4XSN0 Ribosomal large subunit pseudouridine synthase D...    94   6e-18
UniRef50_Q82WZ5 Ribosomal large subunit pseudouridine synthase D...    94   6e-18
UniRef50_Q6AIJ2 Probable ribosomal large subunit pseudouridine s...    94   6e-18
UniRef50_A8U9H8 Pseudouridine synthase n=2 Tax=Bacilli RepID=A8U...    93   7e-18
UniRef50_B8CWM0 Pseudouridine synthase n=1 Tax=Halothermothrix o...    93   7e-18
UniRef50_A6CF60 Pseudouridine synthase n=1 Tax=Planctomyces mari...    93   8e-18
UniRef50_A9CFZ5 Pseudouridine synthase n=3 Tax=Rhizobiales RepID...    93   8e-18
UniRef50_B8I5R6 Pseudouridine synthase n=2 Tax=Clostridium RepID...    93   8e-18
UniRef50_B0S0X9 Pseudouridine synthase n=2 Tax=Finegoldia magna ...    93   8e-18
UniRef50_B2UL66 Pseudouridine synthase n=2 Tax=Verrucomicrobiace...    93   8e-18
UniRef50_D1N7N8 Pseudouridine synthase, RluA family n=1 Tax=Vict...    93   8e-18
UniRef50_A6C0W7 Pseudouridine synthase n=1 Tax=Planctomyces mari...    93   8e-18
UniRef50_C8PW17 Pseudouridine synthase n=5 Tax=Moraxellaceae Rep...    93   9e-18
UniRef50_C4Z9Y6 Pseudouridine synthase n=1 Tax=Eubacterium recta...    93   9e-18
UniRef50_D1VS73 Pseudouridine synthase n=1 Tax=Peptoniphilus lac...    93   9e-18
UniRef50_C8QZ10 Pseudouridine synthase n=1 Tax=Desulfurivibrio a...    93   9e-18
UniRef50_A6TAT3 Pseudouridine synthase n=57 Tax=Bacteria RepID=A...    93   9e-18
UniRef50_C8P3R0 Pseudouridine synthase n=1 Tax=Erysipelothrix rh...    93   9e-18
UniRef50_Q1JVY6 Pseudouridine synthase n=1 Tax=Desulfuromonas ac...    93   1e-17
UniRef50_B1XXM0 Pseudouridine synthase n=6 Tax=Burkholderiales R...    93   1e-17
UniRef50_Q2LWV4 Pseudouridine synthase n=1 Tax=Syntrophus acidit...    93   1e-17
UniRef50_A4J1I1 Pseudouridine synthase n=1 Tax=Desulfotomaculum ...    93   1e-17
UniRef50_A6DUC9 Pseudouridine synthase n=1 Tax=Lentisphaera aran...    92   1e-17
UniRef50_Q14NK8 Probable pseudouridine synthase d protein n=1 Ta...    92   1e-17
UniRef50_C1CWT3 Pseudouridine synthase n=1 Tax=Deinococcus deser...    92   1e-17
UniRef50_C6JBH1 Pseudouridine synthase n=1 Tax=Ruminococcus sp. ...    92   1e-17
UniRef50_D2L0S2 Pseudouridine synthase, RluA family n=1 Tax=Desu...    92   1e-17
UniRef50_C4XFS9 Pseudouridine synthase n=2 Tax=Mycoplasma RepID=...    92   1e-17
UniRef50_O31613 Uncharacterized RNA pseudouridine synthase yjbO ...    92   1e-17
UniRef50_A7HM17 Pseudouridine synthase n=2 Tax=Thermotogaceae Re...    92   1e-17
UniRef50_A0Y082 Pseudouridine synthase n=2 Tax=Alteromonadales R...    92   2e-17
UniRef50_Q2LVB7 Pseudouridine synthase n=1 Tax=Syntrophus acidit...    92   2e-17
UniRef50_A5ZUU7 Pseudouridine synthase n=1 Tax=Ruminococcus obeu...    92   2e-17
UniRef50_UPI00016B2413 ribosomal large subunit pseudouridine syn...    92   2e-17
UniRef50_C9KIU1 Pseudouridine synthase n=3 Tax=Veillonellaceae R...    92   2e-17
UniRef50_Q6AJM1 Pseudouridine synthase n=1 Tax=Desulfotalea psyc...    92   2e-17
UniRef50_B9XDK1 Pseudouridine synthase n=1 Tax=bacterium Ellin51...    92   2e-17
UniRef50_B7PYG1 Ribosomal pseudouridine synthase, putative n=1 T...    92   2e-17
UniRef50_Q7UUI8 Pseudouridine synthase n=1 Tax=Rhodopirellula ba...    92   2e-17
UniRef50_A4J9H9 Pseudouridine synthase n=2 Tax=Clostridiales Rep...    92   2e-17
UniRef50_C8PVB8 Pseudouridine synthase n=2 Tax=Moraxellaceae Rep...    92   2e-17
UniRef50_C0QV86 Pseudouridine synthase n=2 Tax=Brachyspira RepID...    92   2e-17
UniRef50_B0PEI9 Pseudouridine synthase n=5 Tax=Bacteria RepID=B0...    92   2e-17
UniRef50_Q5WF07 Pseudouridine synthase n=1 Tax=Bacillus clausii ...    92   2e-17
UniRef50_C0ZCK6 Pseudouridine synthase n=1 Tax=Brevibacillus bre...    91   3e-17
UniRef50_A8F4Z7 Pseudouridine synthase n=2 Tax=Thermotogaceae Re...    91   3e-17
UniRef50_D2RJC8 Pseudouridine synthase, RluA family n=2 Tax=Veil...    91   3e-17
UniRef50_A4J479 Pseudouridine synthase n=1 Tax=Desulfotomaculum ...    91   3e-17
UniRef50_C0Z877 Pseudouridine synthase n=1 Tax=Brevibacillus bre...    91   3e-17
UniRef50_B1MWE1 Pseudouridine synthase n=3 Tax=Leuconostoc RepID...    91   4e-17
UniRef50_A0L7F8 Pseudouridine synthase n=6 Tax=Proteobacteria Re...    91   4e-17
UniRef50_C1TRW2 Pseudouridine synthase n=1 Tax=Dethiosulfovibrio...    91   4e-17
UniRef50_B9MS57 Pseudouridine synthase n=1 Tax=Anaerocellum ther...    91   4e-17
UniRef50_C8WV14 Pseudouridine synthase n=2 Tax=Alicyclobacillus ...    91   4e-17
UniRef50_B8GX34 Pseudouridine synthase n=7 Tax=Caulobacteraceae ...    91   4e-17
UniRef50_Q0VQA6 Pseudouridine synthase n=7 Tax=Gammaproteobacter...    91   4e-17
UniRef50_Q2CAH0 Pseudouridine synthase n=3 Tax=Proteobacteria Re...    91   4e-17
UniRef50_D2QLU1 Pseudouridine synthase n=53 Tax=Bacteroidetes Re...    91   5e-17
UniRef50_Q38Y05 Pseudouridine synthase, 23S-rRNA-specific n=1 Ta...    91   5e-17
UniRef50_P59831 Ribosomal large subunit pseudouridine synthase A...    91   5e-17
UniRef50_B8J173 Pseudouridine synthase, RluA family n=2 Tax=Desu...    91   6e-17
UniRef50_C7GZU4 Pseudouridine synthase n=1 Tax=Eubacterium saphe...    91   6e-17
UniRef50_UPI00016C4782 RNA pseudouridylate synthase n=1 Tax=Gemm...    91   6e-17

>UniRef50_Q47417 tRNA pseudouridine synthase C n=252 Tax=cellular organisms
           RepID=TRUC_PECCC
          Length = 376

 Score =  387 bits (994), Expect = e-106,   Method: Compositional matrix adjust.
 Identities = 182/257 (70%), Positives = 209/257 (81%)

Query: 1   MLEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGV 60
           MLEI+YQDE LVAVNKPSGWLVHRSWLDR EKVVVMQTVRDQIGQHV+T HRLDRPTSGV
Sbjct: 115 MLEIIYQDEHLVAVNKPSGWLVHRSWLDRKEKVVVMQTVRDQIGQHVYTVHRLDRPTSGV 174

Query: 61  LLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDK 120
           LL+ LSSE  R L+QQFE HQ+QK YHA+VRG+++++ V+DY L EELDKIADKF   DK
Sbjct: 175 LLLALSSEVARALSQQFESHQMQKTYHAVVRGYVLDDGVIDYALTEELDKIADKFTNPDK 234

Query: 121 GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSK 180
            PQPAVTHYR LA  EMPVA GRYPT RY L+EL+P+TGRKHQLRRH++H+ HPIIGD+ 
Sbjct: 235 APQPAVTHYRSLAQAEMPVAIGRYPTARYSLMELKPQTGRKHQLRRHMSHIHHPIIGDTA 294

Query: 181 HGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWRGLL 240
           HGDLR NR    HF   RLMLHAS+L L HP +G+PLT+ A  D  W   ++QFGW+G+L
Sbjct: 295 HGDLRHNRGMESHFSCGRLMLHASELQLNHPVSGQPLTLQARWDAPWQGVVTQFGWKGIL 354

Query: 241 PENERVEFSAPSGQDGE 257
           PE E VEF A SGQD E
Sbjct: 355 PEFEGVEFPADSGQDSE 371


>UniRef50_Q8DBG5 tRNA pseudouridine synthase C n=54 Tax=Gammaproteobacteria
           RepID=TRUC_VIBVU
          Length = 245

 Score =  299 bits (766), Expect = 6e-80,   Method: Compositional matrix adjust.
 Identities = 143/240 (59%), Positives = 175/240 (72%)

Query: 1   MLEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGV 60
           MLEI+YQDE+ VAVNKP+G LVHRSWLD+ E   VMQT+RDQIGQHVF  HRLDRPTSGV
Sbjct: 1   MLEIVYQDEYFVAVNKPAGMLVHRSWLDKHETQFVMQTLRDQIGQHVFPLHRLDRPTSGV 60

Query: 61  LLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDK 120
           L+  LSSE    +   F   ++ K YHAIVRGW+ EE  LDY L  ELDKIADKFA ++K
Sbjct: 61  LVFALSSEVASQVMPMFAGQEMSKTYHAIVRGWIEEEGELDYALKVELDKIADKFASQEK 120

Query: 121 GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSK 180
             Q A+T Y+ LA VE+P +T ++PTTRYGL+EL+PKTGRKHQLRRH+AHLRHPI+GD+ 
Sbjct: 121 EAQDAITLYKPLAKVEVPYSTSKFPTTRYGLMELKPKTGRKHQLRRHMAHLRHPIVGDTT 180

Query: 181 HGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWRGLL 240
           HGD + N+   E F   RL+LHAS+L   HP+T + + I A +D  W Q   +F W   L
Sbjct: 181 HGDGKHNKLFREEFDAPRLLLHASELRFVHPYTQQEVVIRAEVDKVWQQLFERFEWPSTL 240


>UniRef50_B8CQ92 Pseudouridine synthase n=1 Tax=Shewanella piezotolerans WP3
           RepID=B8CQ92_SHEPW
          Length = 278

 Score =  265 bits (678), Expect = 9e-70,   Method: Compositional matrix adjust.
 Identities = 126/235 (53%), Positives = 160/235 (68%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           +EIL++D+ +VA++KP+G LVHRS+L R E+   MQ  RD++G HVF  HRLDRPTSG+L
Sbjct: 27  IEILFEDDDVVAIHKPAGLLVHRSYLARRERFFAMQLTRDKVGCHVFPVHRLDRPTSGIL 86

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKG 121
           L   SSE    L +QF  H I K Y AIVRG + E A LDY L EELD +ADK    +K 
Sbjct: 87  LFAKSSEMANALCEQFAAHSIDKEYLAIVRGNMHEAATLDYALKEELDDVADKDVDPNKA 146

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
            Q A+T Y+ L   E+P A+GRY T+RY LV L P TGRKHQLRRH+AHLRHPI+GD+ H
Sbjct: 147 AQDAITSYKPLLNSEIPYASGRYATSRYALVHLSPHTGRKHQLRRHMAHLRHPILGDTTH 206

Query: 182 GDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGW 236
           GD +QN+   EHFG+ RL L A +LS  HP TGE + +   L+  W+    + GW
Sbjct: 207 GDGKQNKFFREHFGINRLWLIAKKLSFNHPRTGERVAVETELEQEWITLFDELGW 261


>UniRef50_Q15QZ8 Pseudouridine synthase n=5 Tax=Bacteria RepID=Q15QZ8_PSEA6
          Length = 252

 Score =  259 bits (662), Expect = 6e-68,   Method: Compositional matrix adjust.
 Identities = 129/251 (51%), Positives = 163/251 (64%), Gaps = 2/251 (0%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           L ILYQDE LVA++KP+G LVHRS +DR E    MQ +RDQIGQHVF  HRLDRPTSGVL
Sbjct: 3   LTILYQDECLVAIHKPAGLLVHRSMIDRHETQFAMQMLRDQIGQHVFPVHRLDRPTSGVL 62

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKG 121
           +  LS++  RLL +QF  + I K Y AIVRG + E  ++DY L E+LDKIADK A++DK 
Sbjct: 63  VFALSADIARLLGEQFAGNTIAKTYFAIVRGHVKEAGLIDYALKEKLDKIADKRAKQDKD 122

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
            Q A T Y  L   E+P A  RYP+ RY LV L PKTGRKHQLRRH+ H+ HPI+GD+ H
Sbjct: 123 AQEAQTEYVPLQQFELPFAVSRYPSARYTLVRLHPKTGRKHQLRRHMCHINHPIVGDTTH 182

Query: 182 GDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWRGLLP 241
           GD + N+   + F    L L   Q+ +THP + E L I    D      + Q+GW   LP
Sbjct: 183 GDGKHNKFMRDQFSFNGLALTCQQMCMTHPVSNEKLAIVNDFDQRMSTLMVQWGWE--LP 240

Query: 242 ENERVEFSAPS 252
             +R++  + S
Sbjct: 241 SLDRLDLLSNS 251


>UniRef50_Q30SZ1 Pseudouridine synthase n=2 Tax=Proteobacteria RepID=Q30SZ1_SULDN
          Length = 241

 Score =  258 bits (659), Expect = 2e-67,   Method: Compositional matrix adjust.
 Identities = 122/236 (51%), Positives = 166/236 (70%)

Query: 1   MLEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGV 60
           MLEILYQDE LVA+NKPSG LVHRS +DR E    +QT+R+Q+G+ V+  HRLD+PTSGV
Sbjct: 1   MLEILYQDEHLVAINKPSGLLVHRSPIDRHETEFAIQTLRNQLGRFVYPIHRLDKPTSGV 60

Query: 61  LLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDK 120
           LL  L  E+ +++ ++F  H+ +K Y A+VRG+ ++   +DY L  + DKIADK +  DK
Sbjct: 61  LLFALDKESAKIMGEKFMAHEAKKSYIAVVRGYTLQSGEIDYALSIKFDKIADKDSSSDK 120

Query: 121 GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSK 180
            PQ A+THY+ LATVE+    G+Y  TRY LV+L P TGRKHQLRRH+ H+ H I+GD+K
Sbjct: 121 EPQEALTHYKRLATVELDFEVGKYDKTRYSLVKLNPLTGRKHQLRRHMKHISHHILGDTK 180

Query: 181 HGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGW 236
           +G    N+   + FG  R++LHA  L ++HP+T E L I A LD T+++  S FGW
Sbjct: 181 YGRGEHNKLIRQEFGCHRMLLHAIALEISHPYTKELLYIKAPLDVTFIEMFSFFGW 236


>UniRef50_C8PZW5 Pseudouridine synthase n=1 Tax=Enhydrobacter aerosaccus SK60
           RepID=C8PZW5_9GAMM
          Length = 266

 Score =  256 bits (653), Expect = 8e-67,   Method: Compositional matrix adjust.
 Identities = 137/263 (52%), Positives = 166/263 (63%), Gaps = 27/263 (10%)

Query: 1   MLEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGV 60
           MLEILYQDE  VAVNKP+G LVHRSWLDR E   VMQT+RDQ+ Q+V+  HRLDRPTSGV
Sbjct: 1   MLEILYQDEHCVAVNKPAGMLVHRSWLDRHETEFVMQTLRDQLAQYVYPIHRLDRPTSGV 60

Query: 61  LLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEA----VLDYPLVEELDKIADK-- 114
           LL  LSSE+ R L +QFE  Q+QK Y AIVRG+L   A    ++DYPL + LDKI DK  
Sbjct: 61  LLFALSSESARQLCEQFENRQVQKSYLAIVRGYLTVNAQTSGLIDYPLTQILDKIGDKPS 120

Query: 115 --------------FAREDKGP------QPAVTHYRGLATVEMPV-ATGRYPTTRYGLVE 153
                         FA     P      QPA TH++ LAT E P  A  RYPT+R+ L  
Sbjct: 121 LQALQQRKVSSTDMFAEALSSPAELTLLQPAQTHWQCLATTEQPFQARARYPTSRFSLAR 180

Query: 154 LEPKTGRKHQLRRHLAHLRHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFT 213
           L P TGRKHQLRRH+ H+ HPIIGD+ +GD  QNR+  +H G+ RLMLHA  L+      
Sbjct: 181 LTPITGRKHQLRRHMKHVFHPIIGDTSYGDHHQNRAIRQHIGVHRLMLHAHTLAFNRLTD 240

Query: 214 GEPLTIHAGLDDTWMQALSQFGW 236
              + I A +D  W+   +QFG+
Sbjct: 241 NRRVDITAPVDTDWLTMCAQFGF 263


>UniRef50_UPI0001AEC02F pseudouridylate synthase, 23S RNA-specific n=1 Tax=Alteromonas
           macleodii ATCC 27126 RepID=UPI0001AEC02F
          Length = 279

 Score =  249 bits (636), Expect = 6e-65,   Method: Compositional matrix adjust.
 Identities = 119/236 (50%), Positives = 157/236 (66%), Gaps = 3/236 (1%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           L +LYQDE ++A+ KP G LVHRS +DR E V  +QT+RDQIGQHV+ AHRLDRPTSGVL
Sbjct: 42  LPVLYQDEHIIAIEKPPGLLVHRSPIDRHETVFAVQTLRDQIGQHVYPAHRLDRPTSGVL 101

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKG 121
           +   SSE    L QQ    Q+ K YHAIVRG++     +DY L    DKIADK  R  + 
Sbjct: 102 VFSFSSEIAAKLGQQMMDKQVVKTYHAIVRGFVHHTGYIDYALKYRYDKIADKHKRPQQP 161

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
           PQPA T Y+ +A  E+P   G+Y + RY LV+L P TGRKHQLRRH+ H+RHPIIGD+ H
Sbjct: 162 PQPASTMYQSVAKFEVPEPVGKYQSARYSLVKLSPSTGRKHQLRRHMVHIRHPIIGDTTH 221

Query: 182 GDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDT---WMQALSQF 234
           GD +QN+   +HF    L L  +Q+  +HP TG+ ++I++ +      W++ L+ F
Sbjct: 222 GDGKQNKFAKQHFNFNNLALSCTQMGFSHPVTGKWVSINSQMHSEMRLWLEKLAPF 277


>UniRef50_C5TPY8 Pseudouridine synthase n=6 Tax=Proteobacteria RepID=C5TPY8_NEIFL
          Length = 264

 Score =  249 bits (636), Expect = 7e-65,   Method: Compositional matrix adjust.
 Identities = 127/235 (54%), Positives = 161/235 (68%), Gaps = 3/235 (1%)

Query: 1   MLEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGV 60
           ML+I+++D   +AVNKP+G LVHRSWLD+ E    +QT+RDQIGQHV+  HRLDRPTSGV
Sbjct: 27  MLDIIHRDSRTIAVNKPAGMLVHRSWLDKHETRFAVQTLRDQIGQHVYPVHRLDRPTSGV 86

Query: 61  LLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDK 120
           LL  L +EA RLL QQFE   I+K Y AIVRG+L  + ++DY L    DKIA+  A+ + 
Sbjct: 87  LLFALDTEAARLLTQQFENKTIEKTYWAIVRGYLPSDGLIDYALKYMPDKIAE--AQTEA 144

Query: 121 GPQPAVTHYRGLATVEMPVATG-RYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDS 179
             Q A T YR LA  E+P  +  RYPT+RY   EL P TGRKHQLRRH+ H+ HPI+GD+
Sbjct: 145 TLQEAQTAYRCLAQTELPFQSALRYPTSRYSWAELTPYTGRKHQLRRHMKHIFHPIVGDT 204

Query: 180 KHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
            +GDLRQN + AEH G QRLMLHA  LS      G  +T++A  D+ W   + +F
Sbjct: 205 NYGDLRQNHAVAEHIGTQRLMLHARSLSFQSIEDGSRITVNAPTDNDWRLWMEKF 259


>UniRef50_Q39Z12 Pseudouridine synthase n=3 Tax=Proteobacteria RepID=Q39Z12_GEOMG
          Length = 270

 Score =  242 bits (617), Expect = 1e-62,   Method: Compositional matrix adjust.
 Identities = 123/243 (50%), Positives = 160/243 (65%), Gaps = 1/243 (0%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           +EILY+DE LVAV+KP G LVHRS +DR E    +Q VRD +G+ V+  HRLD+PTSGVL
Sbjct: 1   MEILYRDEHLVAVHKPLGLLVHRSPIDRHETRFALQEVRDLLGRRVYPVHRLDKPTSGVL 60

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE-DK 120
           L  L     R L   F    + K Y A+VRG + EE V+D+PL EE D+         ++
Sbjct: 61  LFALDPAFARGLVGAFASGSVTKTYLAVVRGTMPEEGVIDHPLAEEPDRFEQGRGNAGER 120

Query: 121 GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSK 180
            PQ AVT YR LA VE+PVA GRYPT+RY LV L P+TGR+HQLRRHL HL HPI+GD+K
Sbjct: 121 APQSAVTGYRRLADVELPVAVGRYPTSRYSLVSLSPRTGRRHQLRRHLKHLFHPIVGDTK 180

Query: 181 HGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWRGLL 240
           +G+ R NR   E     R++LHA +L++ HP TG PLT+ A ++  +   L++FGW   +
Sbjct: 181 YGEGRHNRFFREELLTVRMLLHAVELTVPHPATGAPLTVCAPVEGAFAALLARFGWLSAV 240

Query: 241 PEN 243
           P  
Sbjct: 241 PSR 243


>UniRef50_B4RVP9 Pseudouridine synthase n=1 Tax=Alteromonas macleodii 'Deep ecotype'
           RepID=B4RVP9_ALTMD
          Length = 265

 Score =  242 bits (617), Expect = 1e-62,   Method: Compositional matrix adjust.
 Identities = 114/222 (51%), Positives = 148/222 (66%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           L +LYQDE ++A++KP G LVHRS +D+ E V  +QT+RDQIGQHVF AHRLDRPTSGVL
Sbjct: 28  LPVLYQDEHIIAIDKPPGLLVHRSPIDKHETVFAVQTLRDQIGQHVFPAHRLDRPTSGVL 87

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKG 121
           +   S++    L +Q    Q+ K+YHAIVRG++     +DY L    DKIADK  R  + 
Sbjct: 88  VFSFSADTAAKLGKQMMDKQVVKQYHAIVRGFVHHTGYIDYALKYRYDKIADKHKRPQQP 147

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
           PQPA T Y  LA  ++P   GRY + RY LV L P TGRKHQLRRH+ H+RHPIIGD+ H
Sbjct: 148 PQPASTMYESLAKFDVPEPVGRYQSARYSLVRLSPSTGRKHQLRRHMVHIRHPIIGDTTH 207

Query: 182 GDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGL 223
           GD +QN+    HF    L L  +Q+  +HP T + +TI+  +
Sbjct: 208 GDGKQNKFAKSHFNFTHLALSCTQMGFSHPVTQKWITINGEM 249


>UniRef50_B5JL25 Pseudouridine synthase n=1 Tax=Verrucomicrobiae bacterium DG1235
           RepID=B5JL25_9BACT
          Length = 249

 Score =  237 bits (605), Expect = 3e-61,   Method: Compositional matrix adjust.
 Identities = 122/230 (53%), Positives = 154/230 (66%), Gaps = 3/230 (1%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           LEILY+DE LVA++KPSG LVHRS +DR E    +Q +RDQIGQHV+ AHR+DRPTSG+L
Sbjct: 14  LEILYRDERLVAIHKPSGLLVHRSPIDRRETRFAIQLLRDQIGQHVYPAHRIDRPTSGIL 73

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKG 121
           L GL   AG  L+  F+  +IQK Y A+ RG L E  ++D PL +  D  AD   +  + 
Sbjct: 74  LFGLDEAAGTALSLLFQNREIQKNYLAVTRGHLPESGLIDSPLHKYED--ADGHIKSSET 131

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
            Q A T YR LAT E+P  T RY TTRY LVEL P TGR+HQ+RRHLAH+RHPIIGD +H
Sbjct: 132 -QEAETAYRRLATTELPYPTERYDTTRYSLVELTPHTGRRHQIRRHLAHIRHPIIGDVRH 190

Query: 182 GDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
           G  + N+    HF + RL+L A+ +   HPFT  PL IH   + ++  AL
Sbjct: 191 GCNKANKLARSHFAIHRLLLAATHVVFVHPFTNAPLKIHCPPETSFQTAL 240


>UniRef50_Q31IZ8 Pseudouridine synthase n=2 Tax=Proteobacteria RepID=Q31IZ8_THICR
          Length = 252

 Score =  229 bits (583), Expect = 1e-58,   Method: Compositional matrix adjust.
 Identities = 114/236 (48%), Positives = 153/236 (64%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
            +ILYQD+ LVAV+KP+G LVHRS +DR E    +Q  RDQI Q V+  HRLD+ TSG+L
Sbjct: 10  FKILYQDDSLVAVHKPAGLLVHRSPIDRHETQFAVQMTRDQINQKVYPLHRLDKATSGLL 69

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKG 121
           L  L S   RL+ QQFE+H IQK Y AI RGW  E   +D+ L  +LDK+ D+ A+ +K 
Sbjct: 70  LFALDSNTARLMGQQFEEHTIQKHYLAICRGWTAEHGEIDHALKHKLDKLGDRHAQTNKP 129

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
           PQ A+T++  LAT ++    G++ + RY LV+L PKTGRKHQLRRHL H+ HPIIGD K+
Sbjct: 130 PQEALTNFERLATTDVMHKIGKFDSQRYSLVKLMPKTGRKHQLRRHLNHISHPIIGDVKY 189

Query: 182 GDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWR 237
           GD   N       G  RL L A+ L+  HP T   +T++A L+ ++ +A     W+
Sbjct: 190 GDRHHNHFFNTWLGQHRLYLAATSLTFNHPQTNARMTLNAPLELSYQKATQHLNWQ 245


>UniRef50_C4KBT4 Transaldolase n=2 Tax=Proteobacteria RepID=C4KBT4_THASP
          Length = 648

 Score =  226 bits (577), Expect = 4e-58,   Method: Compositional matrix adjust.
 Identities = 127/272 (46%), Positives = 165/272 (60%), Gaps = 24/272 (8%)

Query: 1   MLEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGV 60
           MLEILY+D+WLVA++KPSG LVHRS +   E+   +Q +RDQ+G+ V+ AHRLDR TSGV
Sbjct: 1   MLEILYRDDWLVAIHKPSGLLVHRSPIAAHEERFAVQLLRDQLGRRVYPAHRLDRGTSGV 60

Query: 61  LLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIA-------- 112
           LL  L  E  R LAQ+FE   + KRY A+VRG   E  V+++ LV  LD +         
Sbjct: 61  LLFALDREVARTLAQRFEAQAVDKRYLAVVRGHPPEHGVIEHALVRRLDAVEVRSGKGAG 120

Query: 113 ----------DKFAREDKGP--QPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGR 160
                     D  + E   P  QPA T +R LATVE+P A  RYP++RY LVEL P+TGR
Sbjct: 121 ARDALPEDVDDSDSPEAAEPVAQPARTRFRRLATVELPHAVDRYPSSRYALVELLPETGR 180

Query: 161 KHQLRRHLAHLRHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIH 220
           +HQLRRHL H+ HPIIGD+ +G  R NR     FG  RL+L  ++L+L HP T  PL I 
Sbjct: 181 RHQLRRHLKHIAHPIIGDATYGKGRHNRLFQALFGSHRLLLACTRLALAHPVTERPLEIV 240

Query: 221 AGLDDTWMQALSQFGWRGLLPENERVEFSAPS 252
           A + + +   L+  GW+      +R  F A S
Sbjct: 241 APVAEDFAAVLAALGWQ----TAQRSTFEAES 268


>UniRef50_A1K5H7 Pseudouridine synthase n=5 Tax=Proteobacteria RepID=A1K5H7_AZOSB
          Length = 260

 Score =  226 bits (575), Expect = 7e-58,   Method: Compositional matrix adjust.
 Identities = 118/242 (48%), Positives = 152/242 (62%), Gaps = 4/242 (1%)

Query: 1   MLEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGV 60
           MLEILYQDE LVA++KPSG LVHRS LD  E+   +Q +RDQ+G+HV   HRLD+ TSGV
Sbjct: 1   MLEILYQDEHLVAIHKPSGLLVHRSALDAHEERFAVQLLRDQLGRHVHPVHRLDKGTSGV 60

Query: 61  LLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDK 120
           L+  L  +    LA QFE   ++K+Y AIVRG   E   +D+PL    D +  +   EDK
Sbjct: 61  LVFALDRDTAGRLATQFETRAVRKQYVAIVRGHPAEAGTIDHPLSRRFDPV--EHVAEDK 118

Query: 121 --GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
              PQPA+T +R LAT E+P A  RYPT+RY L+ LEP+TGR+HQ+RRHL H+ HPIIGD
Sbjct: 119 VFAPQPAITRFRRLATAELPWAVDRYPTSRYALLALEPETGRRHQIRRHLKHISHPIIGD 178

Query: 179 SKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWRG 238
           S  G  + NR    HFG +R++L  + + L HP    PL +HA     +       GW  
Sbjct: 179 STFGKGKHNRMFQAHFGSERMLLACTDIELRHPQRDAPLQLHAAPAPDFRAVADALGWHD 238

Query: 239 LL 240
            L
Sbjct: 239 AL 240


>UniRef50_Q47Y03 Pseudouridine synthase n=1 Tax=Colwellia psychrerythraea 34H
           RepID=Q47Y03_COLP3
          Length = 304

 Score =  223 bits (569), Expect = 4e-57,   Method: Compositional matrix adjust.
 Identities = 112/282 (39%), Positives = 157/282 (55%), Gaps = 46/282 (16%)

Query: 1   MLEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGV 60
           +L+ILYQDE++VAV+KP+G  VHRS++D+DE    +Q VRDQ+GQ+V+  HRLDRPTSGV
Sbjct: 20  VLDILYQDEYMVAVDKPAGLFVHRSYMDKDEIYFALQLVRDQVGQYVYPVHRLDRPTSGV 79

Query: 61  LLMGLSSEAGRLLAQQFEQHQIQ------------------------------------- 83
           LL  L+ +    L++ F     Q                                     
Sbjct: 80  LLFALTKDVATKLSEAFANKSSQAEFKSDTELEGKVHDKTQTGQQGQQSMTEGLTTDKNI 139

Query: 84  --------KRYHAIVRGWL-MEEAVLDYPLVEELDKIADKFAREDKGPQPAVTHYRGLAT 134
                   K Y+A+ RG L +   ++D+PL E+LDK+ DK    DK  Q A ++Y+    
Sbjct: 140 DGSDLAMVKTYYALARGHLAVPVDLIDHPLKEKLDKLGDKNVSRDKPAQSAQSYYQVKQQ 199

Query: 135 VEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHGDLRQNRSGAEHF 194
             +P+  G++ + RY L+E+ P TGR+HQ+RRHLAHLRHPI+GD  +GD +QN    EHF
Sbjct: 200 ASLPIKVGKFDSVRYSLIEVRPITGRRHQIRRHLAHLRHPILGDINYGDNKQNPFFIEHF 259

Query: 195 GLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGW 236
           G +RLML A  L   HP   + + I A  D+ W Q  + F W
Sbjct: 260 GFKRLMLIAKSLEFNHPINNDRIKISAPFDEQWQQVFTTFEW 301


>UniRef50_A1U2H1 Pseudouridine synthase n=1 Tax=Marinobacter aquaeolei VT8
           RepID=A1U2H1_MARAV
          Length = 245

 Score =  221 bits (564), Expect = 1e-56,   Method: Compositional matrix adjust.
 Identities = 115/231 (49%), Positives = 153/231 (66%), Gaps = 3/231 (1%)

Query: 5   LYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG-QHVFTAHRLDRPTSGVLLM 63
           +Y+D+WL+AV+KP+G LVHRS +D+ E    +Q  R   G +HV+  HRLDRPTSGVLL 
Sbjct: 8   IYRDDWLLAVHKPAGLLVHRSPIDKHETEFALQYARAMNGGEHVYPVHRLDRPTSGVLLF 67

Query: 64  GLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKGPQ 123
               E  R L        + K Y A+VRGW  E+ V+D+PL EE +    +   +++  +
Sbjct: 68  ARDPETARALGLAMMAGAVSKTYLAMVRGWAPEQGVIDHPLREEPED--RRLKGQEQPVR 125

Query: 124 PAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHGD 183
            A+T YR LAT E+PVA  RYPT+RY LVEL+P+TGRKHQLRRH+ H+ HPIIGD+ HG 
Sbjct: 126 EALTRYRRLATTELPVAIERYPTSRYSLVELKPETGRKHQLRRHMKHINHPIIGDANHGR 185

Query: 184 LRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
            R NR  AE FG  RLML A++L L HP T EPL + A  + +++Q L+ F
Sbjct: 186 GRHNRYFAERFGQGRLMLAATELRLRHPVTDEPLCLKAHPESSFLQVLAIF 236


>UniRef50_D2QPA6 Pseudouridine synthase n=1 Tax=Spirosoma linguale DSM 74
           RepID=D2QPA6_9SPHI
          Length = 244

 Score =  215 bits (548), Expect = 9e-55,   Method: Compositional matrix adjust.
 Identities = 110/220 (50%), Positives = 141/220 (64%), Gaps = 6/220 (2%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           L ILYQD  LVA+NKP G LVHRS +  D     +Q +RDQ+GQ V+  HRLDR T+GVL
Sbjct: 11  LSILYQDTELVAINKPHGLLVHRSMIASDASEFAVQLLRDQLGQRVYPVHRLDRKTAGVL 70

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKG 121
           L  LS     ++ QQF +  +QK Y AIVRG+  +E  +DYPL ++    A    +E   
Sbjct: 71  LFALSESMNAIMQQQFMEGAVQKTYLAIVRGYTPDELTIDYPLCKDDGNGAVGVLQE--- 127

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
              AVTH + L   E+PVA G++PT+RY LVEL P TGR HQLRRH+AH+ HPIIGD  H
Sbjct: 128 ---AVTHLKTLRQTEIPVAFGKHPTSRYSLVELTPTTGRMHQLRRHMAHILHPIIGDRPH 184

Query: 182 GDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHA 221
           G  +QN+   EHF +  ++LHA ++  THP T E  TI A
Sbjct: 185 GCNKQNKLFKEHFEMNTMLLHAQRIEFTHPVTQETTTIAA 224


>UniRef50_Q1N5G6 Pseudouridine synthase n=1 Tax=Bermanella marisrubri
           RepID=Q1N5G6_9GAMM
          Length = 236

 Score =  213 bits (543), Expect = 4e-54,   Method: Compositional matrix adjust.
 Identities = 109/234 (46%), Positives = 147/234 (62%), Gaps = 7/234 (2%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLM 63
           ILYQD+ L+A+NKPSG LVH+SW+ +D K   +Q VRD  G+HVF  HRLDRPTSGVLL 
Sbjct: 9   ILYQDDDLIAINKPSGLLVHKSWVAKDAKEFALQIVRDMSGKHVFPVHRLDRPTSGVLLF 68

Query: 64  GLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKGPQ 123
           G S E  + +  Q+EQ    K Y A+VRGWL E+ ++D+ L    D     + ++ +  Q
Sbjct: 69  GFSGEIAQQVQAQWEQ--ANKTYWAVVRGWLKEQTLVDHALKGMAD-----YGQDVEIVQ 121

Query: 124 PAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHGD 183
            A TH++ +  VE+     RYP +R+  VE +PK GR HQ+RRHL HL HPIIGD+++G 
Sbjct: 122 EAQTHFKPIDYVEIDAEIDRYPKSRFSWVEAKPKQGRTHQIRRHLKHLSHPIIGDARYGK 181

Query: 184 LRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWR 237
            + NR   EH+   RL+LH  QL +THP +G  L I A L+       S F W+
Sbjct: 182 GKYNRYITEHYDCPRLLLHHQQLEMTHPVSGSKLMITAPLEGAMQSLFSTFDWK 235


>UniRef50_A4BJ00 Pseudouridine synthase n=1 Tax=Reinekea blandensis MED297
           RepID=A4BJ00_9GAMM
          Length = 249

 Score =  213 bits (541), Expect = 7e-54,   Method: Compositional matrix adjust.
 Identities = 107/240 (44%), Positives = 145/240 (60%), Gaps = 5/240 (2%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQH-----VFTAHRLDRP 56
           L I+Y+D+ L+ V+KPSG L+H SWLDR E   +    +  + Q      V T HRLDRP
Sbjct: 4   LNIVYEDDVLLVVDKPSGLLMHPSWLDRRETDTLAGRAKAYLAQQSEGAKVHTVHRLDRP 63

Query: 57  TSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFA 116
           TSG+++M     A + L +QF++  + KRY AI RG+      LDYPL+EE D+IADKFA
Sbjct: 64  TSGLVVMCKDDHAAKALVEQFQEKTVNKRYWAICRGFAPVAETLDYPLIEEHDRIADKFA 123

Query: 117 REDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPII 176
             DK  Q A+T +R L   E+ +   RYP  R   +E  P TGRKHQ+RRHL HLR+PI+
Sbjct: 124 DSDKPAQEAITEFRRLGITELAIPVSRYPKMRLSWMECVPVTGRKHQIRRHLKHLRYPIL 183

Query: 177 GDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGW 236
           GD++HG    NR+    FG   + L A ++S  HP T E +T + G D+ W   L + GW
Sbjct: 184 GDTRHGCRHLNRAVEGSFGELFMGLRAVEMSFQHPVTNELMTFNVGADNVWSCWLDRLGW 243


>UniRef50_C0Q9S8 TruC n=1 Tax=Desulfobacterium autotrophicum HRM2 RepID=C0Q9S8_DESAH
          Length = 260

 Score =  208 bits (530), Expect = 1e-52,   Method: Compositional matrix adjust.
 Identities = 111/235 (47%), Positives = 138/235 (58%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           LEILYQDE LVAVNKP G LVHR+ L   E    +Q VRDQ   HVF  HRLDRPT GVL
Sbjct: 13  LEILYQDEDLVAVNKPPGLLVHRTALATHETRFALQMVRDQTQGHVFPVHRLDRPTQGVL 72

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKG 121
           L   +      ++  F+  +IQK Y A+VRG + E   + +PL        +K       
Sbjct: 73  LFARNRNMATRMSHLFQTGKIQKTYLAVVRGHVKERGTIVHPLKNIKHPQDNKRINHSLK 132

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
              AVT Y  LA+VE+P    RYPTTRY LV L PKTGR+HQLRRH+ H+ HPI+GD+ +
Sbjct: 133 IDDAVTDYACLASVELPFYVDRYPTTRYCLVALIPKTGRRHQLRRHMKHISHPIVGDTVY 192

Query: 182 GDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGW 236
           G    NR  A H     L+L A +L   HP TG  +TI A LD  + + +S+F W
Sbjct: 193 GKSSHNRFFATHLNCTGLLLAARELCFVHPDTGIFITITAPLDKRFQEVISKFSW 247


>UniRef50_A9BZ16 Pseudouridine synthase n=9 Tax=Burkholderiales RepID=A9BZ16_DELAS
          Length = 319

 Score =  207 bits (526), Expect = 4e-52,   Method: Compositional matrix adjust.
 Identities = 124/270 (45%), Positives = 157/270 (58%), Gaps = 18/270 (6%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           L IL++DE LVAV KP+GWLVHR+ LD  E   V+QT+RDQ+G HV+ AHRLD+ T GVL
Sbjct: 51  LHILWRDEHLVAVYKPAGWLVHRTGLDAHETRFVLQTLRDQLGCHVYPAHRLDKGTCGVL 110

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKG 121
           +M L ++A + L Q F   +++K+Y A+VRGWL +   +D+ L  +        A ED  
Sbjct: 111 VMALHAQAAQRLGQAFAGQEVRKQYLALVRGWLPDAVEVDHALRPD-------DAPEDAP 163

Query: 122 PQPAVTHYRGLATVEMPVA-TGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSK 180
            QPA T  R LA +E P A   R+  TR  LVE  P TGR+HQ+RRHL H+ HPIIGD+ 
Sbjct: 164 AQPAQTSLRCLARLEWPEAFDPRHAATRISLVEALPATGRRHQIRRHLKHVAHPIIGDAT 223

Query: 181 HGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTI--------HAGLDDTWMQALS 232
           HG    NR  AE  GLQRL LHA  L L HP TGEPL          H      W    +
Sbjct: 224 HGKGPLNRWWAERLGLQRLWLHAHALELAHPMTGEPLRFEADWRQLGHVADVQHWRALCA 283

Query: 233 QFGWRGL--LPENERVEFSAPSGQDGEISS 260
             GW+    LP   R + +A +G  G   S
Sbjct: 284 LPGWQACAGLPATARPDQTASAGAPGSGCS 313


>UniRef50_C6VVP1 Pseudouridine synthase n=4 Tax=Bacteroidetes RepID=C6VVP1_DYAFD
          Length = 228

 Score =  205 bits (522), Expect = 1e-51,   Method: Compositional matrix adjust.
 Identities = 107/235 (45%), Positives = 144/235 (61%), Gaps = 11/235 (4%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           LEILY+ + LVA+NKP+G LVHRS +  D  V  +Q +RDQ+ Q V+ AHRLDR TSGVL
Sbjct: 4   LEILYRSDDLVAINKPNGLLVHRSPIASDADVFAVQLLRDQLSQKVYPAHRLDRKTSGVL 63

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKG 121
           L  L+      +  +F + +I K YHAIVRG   +   +DYPL            R+D  
Sbjct: 64  LFALNENVNSEMQGKFMEGEITKTYHAIVRGHTADRGEIDYPL-----------KRDDGV 112

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
            Q AVTH+  LA  E+P A G++ T+RY LV+L P TGR HQLR+H+AH+ HPIIGD  H
Sbjct: 113 TQDAVTHFETLARAEVPFALGKHATSRYSLVQLNPLTGRMHQLRKHMAHIMHPIIGDRPH 172

Query: 182 GDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGW 236
           G  +QNR   E  G+ ++MLHA  +   HP +G+ +TI A     +++  S  G 
Sbjct: 173 GCNKQNRFFKEELGMIQMMLHAVSVEFVHPVSGQHVTIVAPYLSEFVRMRSVLGL 227


>UniRef50_Q1QTG8 Pseudouridine synthase n=2 Tax=Gammaproteobacteria
           RepID=Q1QTG8_CHRSD
          Length = 261

 Score =  199 bits (506), Expect = 8e-50,   Method: Compositional matrix adjust.
 Identities = 112/241 (46%), Positives = 149/241 (61%), Gaps = 6/241 (2%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           L +LYQDE +VAV KPSG LVHRS + RD +V  +QT+R+Q+G+HV+  HRLDRPTSG+L
Sbjct: 5   LPVLYQDERMVAVQKPSGMLVHRSPIARDARVFALQTLRNQLGRHVYPVHRLDRPTSGLL 64

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKG 121
           L  L  E  + L ++F  H++ KRY A+VRG   E+ +LDY L EE     D    + + 
Sbjct: 65  LFALDPEMAQALGEEFTAHRVHKRYLAVVRGVGPEQDLLDYGLREE-----DGSRPKAEM 119

Query: 122 PQ-PAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSK 180
           P+  A T  R L +VE+PV   RYP  RY L+E  P TGR+HQ+RRHLA   +PIIGD+K
Sbjct: 120 PELEAWTAVRRLDSVELPVRIDRYPQVRYSLMEARPWTGRRHQIRRHLARRGYPIIGDAK 179

Query: 181 HGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWRGLL 240
           HG    NR   E     RL+L A  +++ HP     L + A L D      ++FGW+G  
Sbjct: 180 HGKGAHNRFFRERLDSPRLLLAAVGMTVWHPEQARTLQLDAPLADDMQALFARFGWQGHA 239

Query: 241 P 241
           P
Sbjct: 240 P 240


>UniRef50_A6VXE8 Pseudouridine synthase n=2 Tax=Marinomonas RepID=A6VXE8_MARMS
          Length = 242

 Score =  197 bits (502), Expect = 2e-49,   Method: Compositional matrix adjust.
 Identities = 102/236 (43%), Positives = 145/236 (61%), Gaps = 1/236 (0%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           L+IL+QDE LVAVNKP+G LVHR+ L +DE+  V+Q +RDQ G+ VF  HRLDR TSGVL
Sbjct: 3   LDILFQDEHLVAVNKPAGLLVHRTNLAKDEEDAVVQRLRDQTGKWVFPVHRLDRGTSGVL 62

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKG 121
           +M  S E  R L+ QF + + QK YH +VRG+  E  V++YPL +  ++      + +  
Sbjct: 63  VMAFSPEVARRLSTQFAESKTQKTYHCLVRGYCNESGVINYPLAKLNEQKGRSRFKIEGT 122

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
            + A T +  L   ++PV   RY + R   +E+ PK GRKHQ+RRH  H  +P++GDS +
Sbjct: 123 EREAETGFTRLIQYQLPVPVSRYDSMRLSWLEVTPKQGRKHQIRRHFKHHLNPLVGDSCY 182

Query: 182 GDLRQNRSGAEHFGLQ-RLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGW 236
           G    N+   E +    RLMLHAS L   HP T +P+T+ A L D  +  L++  +
Sbjct: 183 GCRHINKVAKELWSEDFRLMLHASSLEFNHPITNQPITLKADLSDKIINILNKLEY 238


>UniRef50_A1WTN6 Pseudouridine synthase n=2 Tax=Ectothiorhodospiraceae
           RepID=A1WTN6_HALHL
          Length = 249

 Score =  195 bits (496), Expect = 1e-48,   Method: Compositional matrix adjust.
 Identities = 110/242 (45%), Positives = 147/242 (60%), Gaps = 10/242 (4%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQH-VFTAHRLDRPTSGV 60
           L ILY+DE L+AV KP+G LVHRS +DRD  VV +Q +RDQ+G H V+  HRLDR T+GV
Sbjct: 11  LAILYRDERLIAVYKPAGLLVHRSNIDRDRDVV-LQRLRDQLGGHWVYPVHRLDRATAGV 69

Query: 61  LLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDK 120
           L+ GL  +A  +LA  F + +I KRY A+VRGW+     +D PL                
Sbjct: 70  LVFGLDPDAASVLAAAFREQRIGKRYQAVVRGWVEAPGRIDRPLGAGRRGEG-------G 122

Query: 121 GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSK 180
            PQPAVT Y  LA  E+P+   RY T R+  + L P+TGR+HQLRRH+  + HPI+GD+ 
Sbjct: 123 APQPAVTDYVPLAWTELPIPVSRYDTARFTRLALHPQTGRQHQLRRHMKAISHPILGDTT 182

Query: 181 HGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWRGLL 240
           HGD   NR   EHFG +RL+L A++L + HP  G  + + A   D  +QA+ +    G  
Sbjct: 183 HGDGANNRFFREHFGARRLLLVATELVVPHPADGGAVRL-ATEPDAELQAIFRRAGLGEA 241

Query: 241 PE 242
           P 
Sbjct: 242 PS 243


>UniRef50_A3HSB5 Pseudouridine synthase n=1 Tax=Algoriphagus sp. PR1
           RepID=A3HSB5_9SPHI
          Length = 237

 Score =  195 bits (496), Expect = 1e-48,   Method: Compositional matrix adjust.
 Identities = 104/238 (43%), Positives = 142/238 (59%), Gaps = 12/238 (5%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           L IL++D+ ++A+NKP+G LVHR+ +   E V  +Q +RDQIG HV   HRLDRPTSG+L
Sbjct: 3   LPILFEDDSIIAINKPAGLLVHRTSIAAQETVFALQILRDQIGMHVHPVHRLDRPTSGIL 62

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADKFAREDK 120
           L     E    L   F + QI+K Y  IVRG    ++A++D+PL  E             
Sbjct: 63  LFAKKEEILPHLKNLFSERQIKKNYLTIVRGIPEQKKALIDHPLKSE----------RSG 112

Query: 121 GPQPAVTHYRGLATVEMPV-ATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDS 179
             Q A T Y+ ++  E+P   TGRYPT+RY L+ + P+TGR HQ+RRHLAH+RH IIGD 
Sbjct: 113 RLQEAQTWYKVISETEIPFDTTGRYPTSRYSLLSVNPETGRTHQIRRHLAHIRHYIIGDK 172

Query: 180 KHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWR 237
           KHGD +QN      FGL+ L+LHA +LS  HP T E + I   + + +   L     +
Sbjct: 173 KHGDNKQNIFFQNQFGLENLLLHAIRLSFNHPITEETIEISCPVPEHFQSILKSLNLQ 230


>UniRef50_A6DMG7 tRNA pseudouridine synthase n=1 Tax=Lentisphaera araneosa HTCC2155
           RepID=A6DMG7_9BACT
          Length = 246

 Score =  189 bits (479), Expect = 1e-46,   Method: Compositional matrix adjust.
 Identities = 105/245 (42%), Positives = 144/245 (58%), Gaps = 12/245 (4%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG-QHVFTAHRLDRPTSGV 60
           ++ LY+DE+LV   K +   VHRS + RD + + +  VR+++G Q+V+  HRLDRP SG 
Sbjct: 7   VKFLYEDEYLVVAKKLAKISVHRSEMCRDRRTL-LTMVRNKLGGQYVYAVHRLDRPVSGP 65

Query: 61  LLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDK 120
           LL   S E  R L +QF +  ++K+Y A+VRGWL  +  +D  L++          + + 
Sbjct: 66  LLFAKSPEMCRELQKQFNEKTVEKKYIALVRGWLEGKGKVDKQLLK----------KSNG 115

Query: 121 GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSK 180
             Q  +T YRGLAT E+    G++PT RYGLVELEP TGR HQLRRH+  L +PIIGDS 
Sbjct: 116 TIQDCLTRYRGLATAEIDEPLGKFPTVRYGLVELEPVTGRYHQLRRHMRDLAYPIIGDST 175

Query: 181 HGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWRGLL 240
            GD  QNR   E F L+RLMLH   LS  HP + E + I+   D   ++   Q G     
Sbjct: 176 DGDSHQNRFFREKFELRRLMLHCFYLSFKHPVSQELIKIYLEPDRDLLRIYEQLGMYEQF 235

Query: 241 PENER 245
            + ER
Sbjct: 236 KQLER 240


>UniRef50_C7LP91 Pseudouridine synthase n=1 Tax=Desulfomicrobium baculatum DSM 4028
           RepID=C7LP91_DESBD
          Length = 245

 Score =  188 bits (478), Expect = 1e-46,   Method: Compositional matrix adjust.
 Identities = 97/239 (40%), Positives = 140/239 (58%), Gaps = 12/239 (5%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           + +L++DE L+AV+KP+G LVHR+     E  + +Q +RDQ+GQ ++  HRLDRPTSG++
Sbjct: 9   IPVLHRDEHLIAVHKPAGLLVHRNAHAGREPFL-LQILRDQLGQRLYPVHRLDRPTSGLM 67

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKG 121
           +M LS +A   LA QF   ++ K Y A+ RG++  + ++D           D    E   
Sbjct: 68  IMALSPQAAHALALQFASQEVHKTYLAVTRGFVPPQGLID-----------DALKSESGS 116

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
            Q A T +  LAT E+P   G  PT RY +V + P+TGR HQ+RRH AH+RHP+IGD   
Sbjct: 117 LQEARTEFTRLATAEIPHPVGPNPTARYSMVRVRPRTGRTHQIRRHFAHIRHPLIGDVLR 176

Query: 182 GDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWRGLL 240
           GD RQNR   +HFGL RL+L + +L+  HP    P+T+        +    Q GW   +
Sbjct: 177 GDGRQNRFFRDHFGLHRLLLASVELTFRHPEDTSPMTLTCPPARELLDLFGQLGWNAAI 235


>UniRef50_Q6MMV3 Pseudouridine synthase n=2 Tax=Bdellovibrio bacteriovorus
           RepID=Q6MMV3_BDEBA
          Length = 290

 Score =  177 bits (449), Expect = 3e-43,   Method: Compositional matrix adjust.
 Identities = 99/235 (42%), Positives = 138/235 (58%), Gaps = 18/235 (7%)

Query: 1   MLEILYQDEWLVAVNKPSGWLVH-----RSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDR 55
           ++E+LY+DE+ +AVNKPSG+ VH     +  + RD+  + +   R  + QHV+  HRLD 
Sbjct: 50  LVELLYKDEYFIAVNKPSGFHVHPHENVQHRVSRDK--ICLYHARRMMKQHVYPVHRLDA 107

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKF 115
            TSGVLL  LSSE+   L + F +    K Y A+VRG++ EE  +  PL  ELD   D  
Sbjct: 108 GTSGVLLFALSSESASKLCRLFTERATHKTYQAVVRGFVKEEGEVQLPL--ELDSTGDLV 165

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGR-YPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
                    A T ++ LATVE PVA G+ +PT RY  VE+ P TGR HQ+RRH   + HP
Sbjct: 166 D--------AHTSFKRLATVEFPVAVGKKFPTARYSWVEVTPHTGRYHQIRRHFNRISHP 217

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQ 229
           ++GD+ HGD   NR    H  ++ L L A +L  THP++GE ++I A   D W +
Sbjct: 218 LLGDAVHGDSHHNRFFRNHLEIEGLCLKALRLEFTHPWSGEKVSIEAPPCDKWKK 272


>UniRef50_B0RLZ1 Pseudouridine synthase n=13 Tax=Xanthomonadaceae RepID=B0RLZ1_XANCB
          Length = 258

 Score =  176 bits (445), Expect = 9e-43,   Method: Compositional matrix adjust.
 Identities = 97/241 (40%), Positives = 139/241 (57%), Gaps = 21/241 (8%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           L+ILYQD  L  V+KP+G +VH S L R E   +   +R Q+G+ +F  HRLDR TSG L
Sbjct: 20  LQILYQDAVLAVVDKPAGLMVHDSKLARGEDDFLADRLRVQLGRPIFLVHRLDRATSGCL 79

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEA-VLDYPLVEELDKIADKFAREDK 120
           L+    +    L +     +++K Y AI RGW  EE  ++D+ L              D 
Sbjct: 80  LLAFDRDTASALGKALMAGEVEKDYLAICRGWPAEERFIVDHDL--------------DG 125

Query: 121 GP-----QPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
           GP     +PAVTH++ LAT E+ + +  + T+RY L+  +P+TGR  Q+RRHL HL H +
Sbjct: 126 GPGKPIKKPAVTHFQRLATGELEIPSTGFATSRYALLRCQPQTGRFRQIRRHLKHLSHHM 185

Query: 176 IGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFG 235
           IGD+ HGD R NRS     G+ R++LHA +L   HP  G  +++ A LD  + +A + FG
Sbjct: 186 IGDTSHGDGRHNRS-FRMLGIHRMLLHAERLGFPHPADGRRISVVAPLDVEFAKACALFG 244

Query: 236 W 236
           W
Sbjct: 245 W 245


>UniRef50_A2U235 Pseudouridine synthase n=3 Tax=Flavobacteriaceae RepID=A2U235_9FLAO
          Length = 234

 Score =  168 bits (425), Expect = 2e-40,   Method: Compositional matrix adjust.
 Identities = 88/242 (36%), Positives = 134/242 (55%), Gaps = 14/242 (5%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDR---DEKVVVMQTVRDQIGQHVFTAHRLDRPTS 58
           LEI+Y+D +L+ V KP+  LVH ++  R   DEK + +Q V ++ G  V+  HRLDR TS
Sbjct: 3   LEIIYEDAYLLCVTKPNNVLVHHAYHSRNMADEKSL-LQLVSEETGLKVYPIHRLDRKTS 61

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           G +L+    E        F ++QIQK Y+ +VRG+      +D P+            R+
Sbjct: 62  GAILLAKEKEYVAKFQDLFTKNQIQKIYYGVVRGFSPSTKRIDSPVK----------GRD 111

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
               + A+T  + LA + + +A   Y ++RY L+EL PKTGR HQLR H   + HP+IGD
Sbjct: 112 ANVHKEALTELKTLAKITLDIAVKPYDSSRYSLIELFPKTGRMHQLRVHSNKISHPLIGD 171

Query: 179 SKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWRG 238
           +K+GD   +    ++FG + L LHA +L   HP+T E L + +     W+Q   +F W+ 
Sbjct: 172 AKYGDKNHDMMFEQNFGFKNLFLHAGKLEFIHPYTQETLILKSTFPTDWIQLFEKFNWKN 231

Query: 239 LL 240
            L
Sbjct: 232 PL 233


>UniRef50_A9GEI0 Pseudouridine synthase n=2 Tax=Myxococcales RepID=A9GEI0_SORC5
          Length = 241

 Score =  152 bits (384), Expect = 1e-35,   Method: Compositional matrix adjust.
 Identities = 99/235 (42%), Positives = 128/235 (54%), Gaps = 25/235 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           L +L+ D+ + A  KPSG LVHR W   D  VV +      +G+ V+  HRLDR TSGVL
Sbjct: 8   LSLLHLDDRVAAFAKPSGLLVHRGW--GDAPVVFVDLAERALGRKVYPVHRLDRATSGVL 65

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKG 121
           L+ L   A  LL  QFEQ   +KRY A+VRG   E   +D+P+            R + G
Sbjct: 66  LVALDPAAAALLCAQFEQGLARKRYLALVRGVPPEHGCVDHPI-----------PRREGG 114

Query: 122 PQ-PAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSK 180
           P+ PAVT +  L  +E           RY +VE  P+TGR HQ+RRHL H+ HPIIGD  
Sbjct: 115 PRVPAVTDFERLHALE-----------RYAVVEARPRTGRLHQVRRHLKHISHPIIGDVN 163

Query: 181 HGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFG 235
           +G    NR   E + L RL LHA++L++ HP TG PL + A L D       Q G
Sbjct: 164 YGKGEHNRLFRERYALHRLALHAAELAVAHPETGAPLRVAAPLPDDLRGPFDQLG 218


>UniRef50_B7RZ07 Putative uncharacterized protein n=1 Tax=marine gamma
           proteobacterium HTCC2148 RepID=B7RZ07_9GAMM
          Length = 143

 Score =  135 bits (339), Expect = 2e-30,   Method: Compositional matrix adjust.
 Identities = 66/143 (46%), Positives = 93/143 (65%)

Query: 99  VLDYPLVEELDKIADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKT 158
           ++D+ L ++ DKIAD+   + +  + AVT +  L TVE+P A  RYP +RY LV L+P+ 
Sbjct: 1   MIDHALQDQPDKIADRNRTQARPTRDAVTRFERLDTVEIPYAVDRYPQSRYSLVALQPEQ 60

Query: 159 GRKHQLRRHLAHLRHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLT 218
           GRKHQLRRH+ HL +PIIGD+KHG    NR  AE +G  RL+L  + +  +HP  G+ + 
Sbjct: 61  GRKHQLRRHMKHLGYPIIGDAKHGKGVHNRFFAEKYGCGRLLLACTGMDFSHPVNGDTVH 120

Query: 219 IHAGLDDTWMQALSQFGWRGLLP 241
           I AGLD  + + LS FGW+   P
Sbjct: 121 IRAGLDAAFQRVLSAFGWKEPSP 143


>UniRef50_A9B3Z2 Pseudouridine synthase n=1 Tax=Herpetosiphon aurantiacus ATCC 23779
           RepID=A9B3Z2_HERA2
          Length = 560

 Score =  133 bits (334), Expect = 6e-30,   Method: Compositional matrix adjust.
 Identities = 87/222 (39%), Positives = 115/222 (51%), Gaps = 21/222 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAH-RLDRPTSGV 60
           +EILY+DE ++ +NKP+G   H    D      V + +R Q+       H RLDR TSGV
Sbjct: 3   IEILYRDEQILVINKPTGVATHAPQGDL-ALTDVERALRAQLQLEYLAIHQRLDRDTSGV 61

Query: 61  LLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGW-LMEEAVLDYPLVEELDKIADKFARED 119
           +L  L   A   LA  F +H I+K Y A+V G  +  + V+D  L    D +    +  D
Sbjct: 62  MLFALDPAANANLATAFAEHTIEKTYQALVYGVPIQTQGVIDAALAPAGDGMIQVASAHD 121

Query: 120 KGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDS 179
           +  Q A+THYR L +          P  R+ L+EL+PKTGR HQLR H   L HPI+GD 
Sbjct: 122 RRAQSAITHYRVLVS---------SPDQRFSLLELQPKTGRTHQLRVHCECLGHPIVGDP 172

Query: 180 KHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHA 221
            +   R            RLMLHAS+L  THP T +PL I A
Sbjct: 173 LYDVAR---------AAPRLMLHASELRFTHPLTQQPLHIQA 205


>UniRef50_Q9KQH0 Ribosomal large subunit pseudouridine synthase C n=59
           Tax=Proteobacteria RepID=RLUC_VIBCH
          Length = 315

 Score =  119 bits (298), Expect = 1e-25,   Method: Compositional matrix adjust.
 Identities = 79/232 (34%), Positives = 121/232 (52%), Gaps = 17/232 (7%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLM 63
           I+Y+D+ L+ +NKPSG  VH         +  ++ +R Q  + +   HR+DR TSG+LL+
Sbjct: 97  IVYEDDHLLILNKPSGTAVHGGSGLHFGAIEALRALRPQ-ARFLELVHRIDRDTSGILLV 155

Query: 64  GLSSEAGRLLAQQFEQHQIQKRYHAIVRG-WLMEEAVLDYPLVEELDKIADKFAREDKGP 122
                A R L  QF +  +QK Y+A+V G W  E  V++ PL   L    +   R +   
Sbjct: 156 AKKRSALRHLQAQFREKTVQKYYYALVMGHWDAECKVVNAPL---LKNEVNSIVRVNPNG 212

Query: 123 QPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHG 182
           +P+ T +R L                  LV+  P TGR HQ+R H  ++ HPI  D ++G
Sbjct: 213 KPSETRFRILEKF-----------AEATLVQASPVTGRTHQIRVHTQYMGHPIAWDDRYG 261

Query: 183 DLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           D R +   A+ FG++RL LHA+ +   HP + + L IHA L+    QAL++ 
Sbjct: 262 DRRFDAYTAQ-FGIERLFLHAANIQFVHPASEKKLEIHAPLEAHLEQALTKM 312


>UniRef50_Q3JQ55 Pseudouridine synthase n=170 Tax=cellular organisms
           RepID=Q3JQ55_BURP1
          Length = 477

 Score =  117 bits (294), Expect = 3e-25,   Method: Compositional matrix adjust.
 Identities = 86/240 (35%), Positives = 123/240 (51%), Gaps = 19/240 (7%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
            EIL++D+ ++ +NKP+G  VH         +  M+  R    + +  AHRLDR TSG+L
Sbjct: 243 FEILFEDDAIIVLNKPAGVAVHGGSGVAFGVIEQMRHARPH-AKFLELAHRLDRETSGIL 301

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRG-WLME---EAVLDYPLVEELDKIADKFAR 117
           ++     A   L +Q  ++++ KRY A V G W  +     V+  PL         K+A 
Sbjct: 302 MLAKKRSALVGLHEQIRENRMDKRYFACVHGDWAADWGRRRVVKAPLF--------KYAT 353

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
            D G +       GL +  +     R+P   Y LVE E KTGR HQ+R HLAHL  PI+G
Sbjct: 354 PD-GERRVRVQEDGLPSHTVFNLVDRWPD--YALVEAELKTGRTHQIRVHLAHLGLPIVG 410

Query: 178 DSKHGDLRQNRSGAEHFG---LQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           D+K+GD   N++ A       ++R+ LHA +L L HP TGEPL   A L     Q + Q 
Sbjct: 411 DAKYGDFALNKALARANAVPSIKRMFLHAHRLRLAHPLTGEPLQFDAPLPAECRQFIDQL 470


>UniRef50_A0L8J2 Pseudouridine synthase n=1 Tax=Magnetococcus sp. MC-1
           RepID=A0L8J2_MAGSM
          Length = 328

 Score =  116 bits (291), Expect = 6e-25,   Method: Compositional matrix adjust.
 Identities = 81/233 (34%), Positives = 125/233 (53%), Gaps = 21/233 (9%)

Query: 5   LYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG--QHVFTAHRLDRPTSGVLL 62
           L++D W++ +NKP+G  VH     +   V  ++   +++G        HRLD+ TSG+LL
Sbjct: 101 LHRDGWILVLNKPAGIPVHGGSGHQWGVVDAVRASLEKLGIEAQAELCHRLDKETSGLLL 160

Query: 63  MGLSSEAGRLLAQQFEQHQIQKRYHAIVRGW-LMEEAVLDYPLVEELDKIADKFAREDKG 121
            GL   A RLL +   ++Q+ K Y  +V+G     + V++ PL +   +  ++    ++G
Sbjct: 161 FGLRPRAVRLLTEAMRENQVTKTYLTLVQGVPAARQGVINQPLSKGNVRGGERMVVVEQG 220

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYG---LVELEPKTGRKHQLRRHLAHLRHPIIGD 178
            Q AVTHYR L +              YG   L+E++ +TGR HQ+R H+  L HP+ GD
Sbjct: 221 GQRAVTHYRVLRS--------------YGVASLLEVQLETGRTHQIRVHMQWLGHPVAGD 266

Query: 179 SKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
            K+GD   N+   E  GL+RL LHAS+L+  HP   + L   A LDD   + L
Sbjct: 267 GKYGDKAFNKWMRER-GLKRLFLHASELAFRHPENEQKLAYQAPLDDELTRVL 318


>UniRef50_Q5QZ45 Pseudouridine synthase n=2 Tax=Gammaproteobacteria
           RepID=Q5QZ45_IDILO
          Length = 315

 Score =  114 bits (284), Expect = 4e-24,   Method: Compositional matrix adjust.
 Identities = 80/232 (34%), Positives = 116/232 (50%), Gaps = 14/232 (6%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLM 63
           ILY+D+ L+ +NKPSG  VH     +   +  ++ +R +  + +   HR+DR TSG+LL+
Sbjct: 94  ILYEDDALMLINKPSGVAVHGGSGLQFGLIEGLRALRPK-EKSLELVHRIDRDTSGLLLV 152

Query: 64  GLSSEAGRLLAQQFEQHQIQKRYHAIVRG-WLMEEAVLDYPLVEELDKIADKFAREDKGP 122
                  R L +Q    ++ K+Y A+VRG W      ++ PL +   K  ++  R D   
Sbjct: 153 AKKRSVLRSLHEQLRNKEMNKQYLALVRGQWQKRVRSVEAPLKKNTLKSGERIVRVDAEG 212

Query: 123 QPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHG 182
           + ++T +R            RY      LVE  P TGR HQ+R H  H  HPI  D K+G
Sbjct: 213 KASLTRFR---------IQQRYKEG--TLVEASPVTGRTHQIRVHALHAGHPIAKDPKYG 261

Query: 183 DLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           D   + + +   GL RL LHA QL   HP TG+ +   A LDD   Q L Q 
Sbjct: 262 DTDFDNTMS-RLGLNRLFLHAWQLRFLHPVTGKEVAFEAPLDDNLQQTLKQL 312


>UniRef50_C9M5C8 Pseudouridine synthase n=1 Tax=Jonquetella anthropi E3_33 E1
           RepID=C9M5C8_9BACT
          Length = 276

 Score =  113 bits (282), Expect = 8e-24,   Method: Compositional matrix adjust.
 Identities = 74/213 (34%), Positives = 110/213 (51%), Gaps = 21/213 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTA---HRLDRPTS 58
           L++LY+ + ++ +NKP+G L   S  D   +  V            F A   HRLDR TS
Sbjct: 49  LDVLYRSDSVLVINKPAGLL---SQPDTKGEDSVATRALGYASDPAFGAQLVHRLDRNTS 105

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           GV+++ L  +A R L   F++    K Y A+V G L     +D PL+++ DK   K  R 
Sbjct: 106 GVMILALDGQALRSLMVCFKERTANKTYLALVSGQLPPSGQIDAPLLKDPDK---KLVRV 162

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
               + AVT +R LAT             ++ L E+E  TGR HQ+R H+ H+ HPI+GD
Sbjct: 163 ASNGERAVTRFRRLAT-----------DGQFSLAEVEILTGRTHQIRVHMNHIGHPILGD 211

Query: 179 SKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHP 211
           +K+GD    +      G++R MLHA+ L +  P
Sbjct: 212 AKYGDF-SAKPQVRRLGIRRPMLHATCLVVNSP 243


>UniRef50_A1AVB5 Pseudouridine synthase n=2 Tax=sulfur-oxidizing symbionts
           RepID=A1AVB5_RUTMC
          Length = 303

 Score =  112 bits (281), Expect = 9e-24,   Method: Compositional matrix adjust.
 Identities = 74/221 (33%), Positives = 118/221 (53%), Gaps = 19/221 (8%)

Query: 5   LYQDEWLVAVNKPSGWLVHR-SWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLM 63
           LY+D+ L+ +NKPSG  VH  S +D    V +++ +R    + +   HRLDR TSGVLL+
Sbjct: 89  LYEDKGLLIINKPSGLSVHSGSGVD----VGIIEALRQIYKKPIELVHRLDRATSGVLLI 144

Query: 64  GLSSEAGRLLAQQFEQHQIQKRYHAIVRG-WLMEEAVLDYPLVEELDKIADKFAREDKGP 122
                  + L +Q  QH ++KRY A+V+G W  +   +D PL +       ++   D   
Sbjct: 145 AKKRSVLKNLHEQLSQHTVEKRYTALVKGVWSKKCHTIDAPLYQN-----SRYIMVDAKG 199

Query: 123 QPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHG 182
           + A++H++ L       + G +  +   LVE+  +TGR HQ+R H  +  H +  D K+G
Sbjct: 200 KYAISHFQPLKN----FSDGGFSAS---LVEISIETGRTHQIRVHAKYAGHALACDDKYG 252

Query: 183 DLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGL 223
           D   +R   +  GL+RL LHA Q   T+P T +   ++A L
Sbjct: 253 DKEFDRQ-VKFKGLKRLFLHAHQFIFTNPLTNDIQKVNASL 292


>UniRef50_B0VCN8 Pseudouridine synthase n=16 Tax=Acinetobacter RepID=B0VCN8_ACIBY
          Length = 212

 Score =  112 bits (280), Expect = 1e-23,   Method: Compositional matrix adjust.
 Identities = 80/222 (36%), Positives = 116/222 (52%), Gaps = 26/222 (11%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLM 63
           ++Y+D+  + ++KPS  L      D  + V+        I       HRLDR TSG+L+ 
Sbjct: 9   LIYRDDDFMVIHKPSDILSVPGKGDLHDSVLTRLVA---IEPRTLLIHRLDRDTSGILVF 65

Query: 64  GLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDK----IADKFARED 119
           GLS      +A+QF+  Q  K Y A+V G L  E  +D P+V +  +    I D  A  +
Sbjct: 66  GLSKRGQSAIARQFQDRQTSKIYEALVAGHLEGEGTVDIPVVYDPSRPPLHIVD--ASHN 123

Query: 120 KGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDS 179
           K   PA+TH++ +   ++    G+ P TR   V+L P TGR HQLR H+ +L HPI+GD+
Sbjct: 124 K---PALTHWQAIEHFQI---QGQ-PVTR---VKLTPITGRSHQLRVHMQYLGHPIVGDT 173

Query: 180 KHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHA 221
            +       +  E   + RL LHA QLS  HP TGE LT + 
Sbjct: 174 LY-------AAPEQLLVPRLCLHAKQLSFNHPVTGESLTFNC 208


>UniRef50_A9GIV4 Pseudouridine synthase n=1 Tax=Sorangium cellulosum 'So ce 56'
           RepID=A9GIV4_SORC5
          Length = 350

 Score =  112 bits (279), Expect = 2e-23,   Method: Compositional matrix adjust.
 Identities = 90/240 (37%), Positives = 126/240 (52%), Gaps = 24/240 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           + +L++D+ L+A++KP+G  VH +       V+ M     + G+ +F AHRLDR TSGVL
Sbjct: 108 IPVLHEDDALLAIDKPAGLPVHPTARYHKSTVIKMMEA-ARPGERLFLAHRLDRETSGVL 166

Query: 62  LMGLSSEAGRLLAQQFEQHQ-IQKRYHAIVRGWLMEEAV-LDYPLVEELDKIADKFARED 119
           L+  + EA R +  QFE+   + KRY AI  GW   +   ++ PL  ELD  A ++  + 
Sbjct: 167 LLCRTPEADRTVKAQFEERTGVVKRYAAIAWGWPERDTFRVELPL--ELDD-ASRYKVKM 223

Query: 120 KGPQPAVTHYRGLATVEMPVATGRY--PTT--RYGLVELEPKTGRKHQLRRHLAHLRHPI 175
           +   P     RGLA+       GR   P T  RY LV    +TGR+HQ+R HLA    P+
Sbjct: 224 RVAPPG----RGLASATACEVLGRRADPLTGRRYALVRCTLETGRQHQIRVHLAASGLPL 279

Query: 176 IGDSKHG-DLRQNRSGAE---------HFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDD 225
           +GD  +G D      GA+            L R  LHA+ L LTHP TGE + I A L D
Sbjct: 280 VGDKLYGPDEGMFARGADGVLTDDDRRALELDRHALHAALLELTHPMTGERVRIEAPLSD 339


>UniRef50_A7H6D3 Pseudouridine synthase n=6 Tax=Cystobacterineae RepID=A7H6D3_ANADF
          Length = 339

 Score =  111 bits (277), Expect = 3e-23,   Method: Compositional matrix adjust.
 Identities = 83/261 (31%), Positives = 131/261 (50%), Gaps = 37/261 (14%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHV---------FTAHRLD 54
           +L++D  ++AV+KP+G   H         +V M   R  +G              AHRLD
Sbjct: 87  VLHEDADVLAVDKPAGLAAHPGTGISGATLVEM--ARAHLGTPADLPPTEFKPSPAHRLD 144

Query: 55  RPTSGVLLMGLSSEAGRLLAQQF-EQHQIQKRYHAIVRGWLMEEA-VLDYPLVEELDKIA 112
           R TSGV+L+  + +    L + F +   ++K Y A+V+G +  EA  +D PL E      
Sbjct: 145 RDTSGVVLVAKNRKTMVRLTELFTDGADVKKTYLALVKGKMPREAGTIDLPLAEHEQTAR 204

Query: 113 DKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLR 172
            K AR     Q A+T ++ ++ ++              L+ +  +TGR HQ+RRHL  + 
Sbjct: 205 SKAAR-GVNLQEALTRWKVVSAMK-----------EASLLAVTIETGRTHQIRRHLEAVG 252

Query: 173 HPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALS 232
           HP++GD ++GD   NR+  + +GL+R+ LHA +L L HP TG PL + A L    ++ALS
Sbjct: 253 HPVLGDRRYGDFPTNRAARQRWGLRRMFLHAWRLELPHPTTGAPLRLEAPLPGELLEALS 312

Query: 233 QFGWRGLLPENERVEFSAPSG 253
                       R   S+P+G
Sbjct: 313 ------------RANLSSPAG 321


>UniRef50_Q8ZQ16 Ribosomal large subunit pseudouridine synthase C n=110
           Tax=Gammaproteobacteria RepID=RLUC_SALTY
          Length = 319

 Score =  111 bits (277), Expect = 3e-23,   Method: Compositional matrix adjust.
 Identities = 77/230 (33%), Positives = 118/230 (51%), Gaps = 14/230 (6%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLM 63
           ILY+D+ ++ +NKPSG  VH         +  ++ +R +  + +   HRLDR TSGVLL+
Sbjct: 95  ILYEDDHILVLNKPSGTAVHGGSGLSFGVIEGLRALRPE-ARFLELVHRLDRDTSGVLLV 153

Query: 64  GLSSEAGRLLAQQFEQHQIQKRYHAIVRG-WLMEEAVLDYPLVEELDKIADKFAREDKGP 122
                A R L +Q  +  +QK Y A+VRG W      +  PL++ + +  ++  R  +  
Sbjct: 154 AKKRSALRSLHEQLREKGMQKDYLALVRGQWQSHVKTVQAPLLKNILQSGERIVRVSQEG 213

Query: 123 QPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHG 182
           +P+ T ++            RY      LV   P TGR HQ+R H  +  HPI  D ++G
Sbjct: 214 KPSETRFK---------VEERYAFA--TLVRCSPVTGRTHQIRVHTQYAGHPIAFDDRYG 262

Query: 183 DLRQNRSGAEH-FGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
           D   ++   E   GL+RL LHA+ L  THP TGE + I A +D+   + L
Sbjct: 263 DREFDQQLTEAGTGLKRLFLHAAALKFTHPGTGEVMRIEAPMDNALKRCL 312


>UniRef50_C7LVL1 Pseudouridine synthase n=5 Tax=Proteobacteria RepID=C7LVL1_DESBD
          Length = 234

 Score =  110 bits (276), Expect = 3e-23,   Method: Compositional matrix adjust.
 Identities = 84/226 (37%), Positives = 121/226 (53%), Gaps = 28/226 (12%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIGQHVFTAHRLDRPTSG 59
           L ++++D  +V VNKPSG L   S   R  ++   V+  VR +I +     HRLD  TSG
Sbjct: 16  LAVIHEDRDMVVVNKPSGLL---SVPGRTPELFDSVLSRVR-EIHRGAQAVHRLDLGTSG 71

Query: 60  VLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEA-VLDYPLVEELDKIADKFARE 118
           VL++    +A  +L QQF+    +K Y A V+G + E++  +D PL+ +      +    
Sbjct: 72  VLVVATRRKAETILRQQFQDRLTRKLYLARVQGVMSEDSGQVDLPLICDWPNRPMQMVCH 131

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
           D G +PA+T Y+ L +                LV L P TGR HQLR H+A L HPI+GD
Sbjct: 132 DTG-KPALTDYQVLES-----------DGESTLVLLRPHTGRSHQLRVHMASLGHPILGD 179

Query: 179 SKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLD 224
           + +G+ R           +RL+LHASQL L HP++GE  T HA  D
Sbjct: 180 NLYGEQRPG---------ERLLLHASQLGLYHPYSGEWTTFHAPCD 216


>UniRef50_B6G997 Pseudouridine synthase n=1 Tax=Collinsella stercoris DSM 13279
           RepID=B6G997_9ACTN
          Length = 227

 Score =  110 bits (276), Expect = 3e-23,   Method: Compositional matrix adjust.
 Identities = 83/244 (34%), Positives = 119/244 (48%), Gaps = 35/244 (14%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTA----------- 50
           L +LY+D WL+AV+KP+G +VH              T+ D +  H+  +           
Sbjct: 7   LRVLYRDPWLMAVDKPAGIIVHGDGTG-------APTLTDAVRAHLVASGEASASAAAQA 59

Query: 51  -HRLDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELD 109
             RLDR T+G++L  L  EA     +   +  IQKRY AIV G       +  PL    D
Sbjct: 60  LQRLDRDTTGIVLFSLDKEAQPAFDRMIAERSIQKRYLAIVHGRFPAAKTMCQPLGR--D 117

Query: 110 KIADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLA 169
           +   +  R  +  +PA T  + +A  +   A  R P     L+ ++  TGRKHQ+R HLA
Sbjct: 118 RHDSRRMRVSRTGKPAHTDAKRIAYAK---ADARAP--ERSLLAIDLHTGRKHQIRVHLA 172

Query: 170 HLRHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQ 229
           H + P++GDS +G    + SG        LMLHAS+LS THP TG P  I A     + +
Sbjct: 173 HAKFPLLGDSLYGG--PSCSGG-------LMLHASELSFTHPITGAPTHIQAPYPARFQR 223

Query: 230 ALSQ 233
            +SQ
Sbjct: 224 IMSQ 227


>UniRef50_A7HL94 Pseudouridine synthase n=2 Tax=Thermotogaceae RepID=A7HL94_FERNB
          Length = 317

 Score =  110 bits (275), Expect = 5e-23,   Method: Compositional matrix adjust.
 Identities = 68/227 (29%), Positives = 115/227 (50%), Gaps = 31/227 (13%)

Query: 2   LEILYQDEWLVAVNKPSGWLVH-RSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGV 60
           L+I+Y+DE ++A+NKP+G  VH    +++   +  +     + G   F  HRLD+ TSGV
Sbjct: 99  LDIIYEDELIIAINKPAGVSVHPGKNVNKPSIIEGLIHYGKENGFEPFLVHRLDKETSGV 158

Query: 61  LLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDK 120
           L++       R L++      ++K Y+A+V G  +++  ++ P+                
Sbjct: 159 LIVAKDRSVARELSEIISSRNVEKIYNALVFGK-VQKVTINTPI---------------- 201

Query: 121 GPQPAVTHYRGLATVEMPVATGRYP----TTRYGLVELEPKTGRKHQLRRHLAHLRHPII 176
             Q AV+H        +P+   R      +     +E+E +TGRKHQ+R+HL+ +  PI+
Sbjct: 202 DGQDAVSHI-------IPIEYFRVKLNGISVELSFLEVEIETGRKHQIRKHLSSINCPIV 254

Query: 177 GDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGL 223
           GD  +G+ R NR  +++FGL+R  LH  Q+     F G    I A L
Sbjct: 255 GDKDYGNFRLNREFSKNFGLKRHFLHCKQMKFV--FNGRNYNILAQL 299


>UniRef50_B5YAZ5 Pseudouridine synthase n=2 Tax=Dictyoglomus RepID=B5YAZ5_DICT6
          Length = 226

 Score =  110 bits (275), Expect = 5e-23,   Method: Compositional matrix adjust.
 Identities = 72/239 (30%), Positives = 127/239 (53%), Gaps = 32/239 (13%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ------HVFTA--HRL 53
           LE++Y+D  L+ VNKP+G LV     D  +   +++  +  I +      +VF A  HRL
Sbjct: 7   LEVIYEDNHLLVVNKPAGILVQG---DITKSTTLLEISKAYIKEKYKKPGNVFLAIVHRL 63

Query: 54  DRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRG-WLMEEAVLDYPLVEELDKIA 112
           D+P SGV++   +S++   L++ F + +++K Y A+ +G + +++  +   L+    +  
Sbjct: 64  DKPVSGVVIFARNSKSAGRLSEAFRERKVEKEYIALCKGIFKVKKGTISESLLWVEKERK 123

Query: 113 DKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLR 172
            + +++DK  + A+THY  L   +              LV L P+TGRKHQLR HL+++ 
Sbjct: 124 ARVSQDDKS-KNAITHYEVLEEFK-----------NLSLVRLIPETGRKHQLRAHLSYIG 171

Query: 173 HPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
           HPI+GD K+G       G   F   R+ LH  ++++ HP   + +   A + D W + L
Sbjct: 172 HPILGDEKYG-------GGRIFK-DRIFLHCKKMAVPHPVRKDIMEFEAKIPDFWSEFL 222


>UniRef50_B1H073 Ribosomal large subunit pseudouridine synthase C n=1 Tax=uncultured
           Termite group 1 bacterium phylotype Rs-D17
           RepID=B1H073_UNCTG
          Length = 238

 Score =  110 bits (274), Expect = 6e-23,   Method: Compositional matrix adjust.
 Identities = 77/246 (31%), Positives = 123/246 (50%), Gaps = 30/246 (12%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           +EI+YQDE ++ VNKPSG  V       + K +V + +R+Q+ Q ++  H +DR  SGVL
Sbjct: 5   IEIIYQDENILVVNKPSGMFVIPGRNIYENKTLV-EILRNQLKQKLWVVHIIDRDASGVL 63

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADKFAREDK 120
           +   + E  R ++ QFE  +I+K+Y A++ G L E E  ++ PL+     I+ K  R D 
Sbjct: 64  VFAKNPETHRNISVQFENSKIRKKYIALLSGVLEENEGTINKPLI-----ISGKNVRIDI 118

Query: 121 GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSK 180
             + ++T ++ L                Y LV   P T ++HQ+R H   L HP+  D +
Sbjct: 119 TGKESITDFKVLENFR-----------SYTLVNALPLTVKRHQIRIHFWSLGHPLAIDGE 167

Query: 181 HGDL------------RQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWM 228
           +G L            +  +   E+  + RL LHA+ L+L  P +GE  T  A L   + 
Sbjct: 168 YGTLDPIFLSSFKRGYKIKKGKTENPLISRLTLHAAALTLILPGSGEEKTFEAALAKDFE 227

Query: 229 QALSQF 234
            A+ Q 
Sbjct: 228 VAVKQL 233


>UniRef50_Q89AH2 Ribosomal large subunit pseudouridine synthase C n=5 Tax=Buchnera
           aphidicola RepID=RLUC_BUCBP
          Length = 315

 Score =  110 bits (274), Expect = 7e-23,   Method: Compositional matrix adjust.
 Identities = 69/232 (29%), Positives = 115/232 (49%), Gaps = 13/232 (5%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLM 63
           ILY+D + + +NKPSG  VH         +  ++ +R    +++   HRLDR TSGVL++
Sbjct: 95  ILYEDNYFLILNKPSGMSVHSGSGINYGMIENLRILRPY-NRYLDLVHRLDRDTSGVLII 153

Query: 64  GLSSEAGRLLAQQFEQHQIQKRYHAIVRG-WLMEEAVLDYPLVEELDKIADKFAREDKGP 122
                  R L +Q  + +I+K+Y A+V G W      +  PL++   +      + D   
Sbjct: 154 AKKRSILRNLHEQLREKKIKKKYVALVHGVWPDILKSISKPLLKTSSRKNKNIVKIDPKG 213

Query: 123 QPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHG 182
           + ++TH+             +Y  T+  L+ + P TGR HQ+R HL HL +PI+ D+K+G
Sbjct: 214 KESITHFN---------IKKKY--TKNTLISITPITGRTHQIRVHLLHLNYPIVLDAKYG 262

Query: 183 DLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
             + +      F + RL+LHA  ++  HP   + + I A LD  +   L   
Sbjct: 263 IKKLDYFIKNKFNINRLLLHAESINFFHPKRKKNILITAPLDYVFKTVLKNL 314


>UniRef50_Q1DCE5 Pseudouridine synthase, RluA family n=2 Tax=Cystobacterineae
           RepID=Q1DCE5_MYXXD
          Length = 310

 Score =  109 bits (272), Expect = 1e-22,   Method: Compositional matrix adjust.
 Identities = 75/228 (32%), Positives = 115/228 (50%), Gaps = 17/228 (7%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           L +LY+D  ++AV+KP+G     +     + +V +  V  ++G+     HRLDR TSGV 
Sbjct: 82  LRVLYEDADVIAVDKPAGVSAQPTEGRVGDSLVDL--VGAKLGRPAGLVHRLDRETSGVT 139

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKG 121
           + G ++EA   LA +F + + +KRY A     L     +D PL ++  +     A     
Sbjct: 140 VFGKTAEATSALAAEFREGRARKRYVAATGPGLPPSGTVDLPLSKDPSRPGRWRATRAAN 199

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
             PA+T +  L++              + +VEL P TGR HQLR HL  L  PI+GD+++
Sbjct: 200 GVPALTDFHTLSS-----------GPAFCVVELLPHTGRTHQLRAHLTALGAPILGDARY 248

Query: 182 GDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQ 229
           G   +    AE     R +LHA  L L HP TG+ L I A + +  M+
Sbjct: 249 GGAAR----AEGVEAPRCLLHAQALELGHPRTGKLLRIEAPVPEDLMR 292


>UniRef50_C4FYR8 Pseudouridine synthase n=1 Tax=Abiotrophia defectiva ATCC 49176
           RepID=C4FYR8_ABIDE
          Length = 326

 Score =  109 bits (272), Expect = 1e-22,   Method: Compositional matrix adjust.
 Identities = 73/241 (30%), Positives = 117/241 (48%), Gaps = 20/241 (8%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIGQ-----HVFTAHRLD 54
           L+ILY+DE ++ +NKP G +VH +       +V  +M   RD +            HR+D
Sbjct: 99  LDILYEDEDVILINKPKGMVVHPAAGHYTGTLVNALMYHCRDNLSGINGELRPGIVHRID 158

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADK 114
             T+GV++   +  + R++A+Q ++H I+++Y AIV G   +E       +        K
Sbjct: 159 MDTTGVIIACKNDVSHRIIAEQLKEHSIKRKYQAIVYGVFKDEEGRIEGSIGRSKTDRKK 218

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
            A    G +PAVTHYR +     P          +  +E E +TGR HQ+R H+  + HP
Sbjct: 219 MAVIPDG-KPAVTHYRVIRNYTSPNG------NNFAHIECELETGRTHQIRVHMTSIGHP 271

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           ++GD  +G      +    F L    LHA  L   HP TGE +  HA L + + + L++ 
Sbjct: 272 LLGDEIYG------AAKNPFKLDGQALHAEMLGFVHPRTGEYMEFHAPLPEYFSKLLTKL 325

Query: 235 G 235
            
Sbjct: 326 A 326


>UniRef50_Q0F3G4 Pseudouridine synthase n=1 Tax=Mariprofundus ferrooxydans PV-1
           RepID=Q0F3G4_9PROT
          Length = 315

 Score =  108 bits (271), Expect = 1e-22,   Method: Compositional matrix adjust.
 Identities = 76/232 (32%), Positives = 121/232 (52%), Gaps = 13/232 (5%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG-QHVFTAHRLDRPTSGV 60
           + +LY+D+ L+ VNKP+G +VH        +  +++ ++   G   +  AHRLDR TSGV
Sbjct: 94  IPVLYEDDSLLVVNKPAGMVVHGG---SGHEAGLIEALKQSRGLDDLRLAHRLDRDTSGV 150

Query: 61  LLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEA-VLDYPLVEELDKIADKFARED 119
           LLM    +A R L + F +  +QK Y A++ G     A  +   L + + +  ++   + 
Sbjct: 151 LLMAKHLDALRRLTESFRERDMQKTYFALIAGHPYAHAGRMSSNLAKGVVRGGERMVVDS 210

Query: 120 KGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDS 179
           +  + +VT Y+ +   E       +P   Y +V L P +GR HQLR  L H  HPI+GD 
Sbjct: 211 EEGKASVTDYQVMIEYERH----GFP---YAMVALNPHSGRTHQLRVQLQHEGHPILGDG 263

Query: 180 KHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
           K+G+ +   +  +  G + LMLHA +L  THP +G+ L   A   D W   L
Sbjct: 264 KYGE-KAQLAAYKSLGGKGLMLHAWRLRFTHPVSGKSLECKAPWPDNWSALL 314


>UniRef50_D1Y726 Ribosomal large subunit pseudouridine synthase D n=1
           Tax=Pyramidobacter piscolens W5455 RepID=D1Y726_9BACT
          Length = 315

 Score =  108 bits (271), Expect = 1e-22,   Method: Compositional matrix adjust.
 Identities = 72/210 (34%), Positives = 108/210 (51%), Gaps = 19/210 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFT--AHRLDRPTSG 59
           L+++Y D  ++ VNKP+G L       + E  VV + +   +         HRLDR TSG
Sbjct: 85  LDVIYSDRCVMVVNKPAGLLSQPDV--KGEDSVVTRALGYAVDPEFPPQLVHRLDRNTSG 142

Query: 60  VLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARED 119
           V+ + L     R L + F+  +  KRY AIV G L E   +D PL+++ DK   K  R D
Sbjct: 143 VMALALDGPTTRALMECFKARRADKRYWAIVIGELPERGRIDVPLLKDADK---KLVRVD 199

Query: 120 KGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDS 179
              + AVT Y+ L +           +  + L E+   TGR HQ+R H+ H+ HP++GD 
Sbjct: 200 PKGERAVTEYKRLTS-----------SGAFSLAEVHLLTGRTHQIRVHMNHVGHPLLGDV 248

Query: 180 KHGDLRQNRSGAEHFGLQRLMLHASQLSLT 209
           K+GD   ++      G++R MLHA  L+L 
Sbjct: 249 KYGDF-GSKGQLRSLGVKRPMLHARSLTLN 277


>UniRef50_B7G0Q3 Predicted protein (Fragment) n=1 Tax=Phaeodactylum tricornutum CCAP
           1055/1 RepID=B7G0Q3_PHATR
          Length = 200

 Score =  108 bits (271), Expect = 1e-22,   Method: Compositional matrix adjust.
 Identities = 69/208 (33%), Positives = 99/208 (47%), Gaps = 11/208 (5%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLM 63
           + YQD W V VNKP+G   HRS  +R  + VV   ++ Q+ + VF  HRLD  TSG LL 
Sbjct: 1   LCYQDRW-VCVNKPAGMSTHRSGGNRSNQFVVSTLLKRQLSRKVFPVHRLDHRTSGALLF 59

Query: 64  GLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKGPQ 123
              SE    L     +   +K Y  +VRG+            E      DK    D   +
Sbjct: 60  AFDSEMCASLHDALREQSARKTYVCLVRGFWDN-------FFESDTATVDKALTVDGTKR 112

Query: 124 PAVTHYRGLATVEMPVATG---RYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSK 180
            A T +  LA+  +   +    +       L+   P TGR HQ+RRH + +  P++GD++
Sbjct: 113 SATTVFTKLASTIILNNSAYGEKNVPISCSLILAVPTTGRTHQIRRHASAMGMPVLGDTQ 172

Query: 181 HGDLRQNRSGAEHFGLQRLMLHASQLSL 208
           HG+ + NR   +  GL RL LH   L+L
Sbjct: 173 HGETKVNRWWRQKRGLDRLALHCLSLNL 200


>UniRef50_Q492Q1 Pseudouridine synthase n=2 Tax=Candidatus Blochmannia
           RepID=Q492Q1_BLOPB
          Length = 338

 Score =  108 bits (271), Expect = 1e-22,   Method: Compositional matrix adjust.
 Identities = 77/251 (30%), Positives = 121/251 (48%), Gaps = 33/251 (13%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLM 63
           I+Y+D++L+A+NKP+G   H     +   +  ++ +R +  Q +   HRLDR TSGVLL+
Sbjct: 94  IIYEDDYLLALNKPTGVAAHGGSGLKFGVIEGLRALRPK-AQFLELVHRLDRETSGVLLV 152

Query: 64  GLSSEAGRLLAQQFEQHQIQKRYHAIVRG-WLMEEAVLDYPLVEELDKIADKFAREDKGP 122
                A   L +Q     ++K Y A+V G W +   ++  PL ++               
Sbjct: 153 AKRRTALVYLHEQLRLQNMKKEYLALVHGRWNVNLQIVSVPLFKK--------------- 197

Query: 123 QPAVTHYRGLATVEMPVATGRYPTTRYGLVE----------LEPKTGRKHQLRRHLAHLR 172
               T       V +    G++ TT + + E          ++P TGR HQ+R H  +  
Sbjct: 198 ---NTLLNSSRVVYIDSENGKFSTTHFQIKEYFDNVATFLAIKPITGRTHQIRVHTQYAS 254

Query: 173 HPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALS 232
           HPI+GD+++GD + N +  + FG  RL LHAS L   HP T +   IHA L  ++   L 
Sbjct: 255 HPIVGDNRYGDYQSN-TRFKRFGFNRLFLHASILRFIHPKTKKKFHIHAPLGQSFHNCL- 312

Query: 233 QFGWRGLLPEN 243
            F  R L  +N
Sbjct: 313 -FFLRNLSIKN 322


>UniRef50_C0N6T7 Pseudouridine synthase n=1 Tax=Methylophaga thiooxidans DMS010
           RepID=C0N6T7_9GAMM
          Length = 318

 Score =  108 bits (270), Expect = 2e-22,   Method: Compositional matrix adjust.
 Identities = 71/233 (30%), Positives = 125/233 (53%), Gaps = 14/233 (6%)

Query: 3   EILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLL 62
           +I+++D+ ++ +NKPSG  VH     +   +   + ++ ++   +   HRLDR TSG LL
Sbjct: 96  DIIFEDDSMLVLNKPSGLAVHAGSQIQVGVIEAFRIIKPELA-FLELVHRLDRDTSGCLL 154

Query: 63  MGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADKFAREDKG 121
           +  S ++   L QQ    QI KRY  +++G L   E +++ PL++      ++  +    
Sbjct: 155 LAKSRDSLLNLQQQMLSDQIDKRYLTLLKGILPNAEELVEQPLLKNTVSSGERMVKVTPD 214

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
            + A T +  +   ++ +A          L E++  TGR HQ+R H A  +HP+ GD K+
Sbjct: 215 GKRAKTLF--IRQQDLSLAQ---------LTEVKLYTGRTHQIRVHAAWTQHPVAGDDKY 263

Query: 182 GDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           GD   N++  + FGL+RL LHA +L + HP +GEP+ + A L     Q +++ 
Sbjct: 264 GDREFNKT-LKSFGLKRLFLHAWRLGIRHPVSGEPMQLEAPLPTALQQVITKL 315


>UniRef50_B8FLB4 Pseudouridine synthase n=2 Tax=Bacteria RepID=B8FLB4_DESAA
          Length = 321

 Score =  108 bits (269), Expect = 2e-22,   Method: Compositional matrix adjust.
 Identities = 84/242 (34%), Positives = 121/242 (50%), Gaps = 23/242 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIG----QHVFTAHRLDR 55
           L ILY+D  +VAVNKP G +VH +       +V  ++   +D  G    Q     HRLD+
Sbjct: 83  LAILYEDRDIVAVNKPPGMVVHPAPGHSSNTLVNALLAHCKDLSGIGGVQRPGIVHRLDK 142

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEA-VLDYPLVEELDKIADK 114
            TSGV+L   +  A   L++Q  Q +++K Y A+  G + E+  V+D PL          
Sbjct: 143 ETSGVILAAKNDAAHAGLSEQLAQRRVEKFYLALAHGVIKEDTGVIDLPLARH------- 195

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
               D+      T  +G   + +     R+    Y  V+++ KTGR HQ+R HLA L HP
Sbjct: 196 --PSDRKRMHVSTPAKGREALSLWTVKERFLDATY--VKVQIKTGRTHQIRVHLAALHHP 251

Query: 175 IIGDSKHGDLRQ-NRSGAEHFGL----QRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQ 229
           +IGD+ +G  ++  R  A   G     +R MLHA  +S THP TGE LT+ A L     Q
Sbjct: 252 VIGDTVYGGRKKRGRLPASVLGKAPPPERQMLHAHIVSFTHPVTGEKLTLTAPLPQDMAQ 311

Query: 230 AL 231
            L
Sbjct: 312 LL 313


>UniRef50_Q1ILA4 Pseudouridine synthase n=1 Tax=Candidatus Koribacter versatilis
           Ellin345 RepID=Q1ILA4_ACIBL
          Length = 333

 Score =  107 bits (267), Expect = 4e-22,   Method: Compositional matrix adjust.
 Identities = 71/247 (28%), Positives = 134/247 (54%), Gaps = 31/247 (12%)

Query: 2   LEILYQDEWLVAVNKPSGWLVH----RSWLDRDEKVVVMQTVR-----DQIGQHVF--TA 50
           L+++Y+D+ L  +NKP+G +VH     +  +R+   +V   +       ++G  +     
Sbjct: 82  LDVVYEDDDLAVINKPAGMMVHVGAGATEEERNRGTLVNALLYRFRALSEVGGDMRPGIV 141

Query: 51  HRLDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELD 109
           HRLD+ TSG++++  +  A R LA+QF   ++ K+Y A+V GW  + +  ++ P+  ++ 
Sbjct: 142 HRLDKETSGLIVVAKNDVAHRKLAEQFSSRRVHKKYVALVHGWPKKLKGTINLPIARDMS 201

Query: 110 KIADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLA 169
           +   +      G + A++HY     +E P         ++ LVE++ +TGR HQ+R H+A
Sbjct: 202 R-RTRMTTRGSGGRDALSHYEVKEKIESPYG-------KFALVEVKIETGRTHQIRVHMA 253

Query: 170 HLRHPIIGDSKH---GDLRQNRS----GAEHFGLQRLMLHASQLSLTHPFTGEPL----T 218
            L HP++GD+ +   G+LR  ++     ++   L+R  LHA+++ L  P TG+ L     
Sbjct: 254 SLGHPVVGDTLYGAPGELRVTKALKGMPSKMASLERNFLHAAEIELQQPATGKALRFVTK 313

Query: 219 IHAGLDD 225
           + A L+D
Sbjct: 314 VPAALED 320


>UniRef50_B0TGQ0 Pseudouridine synthase n=44 Tax=Bacteria RepID=B0TGQ0_HELMI
          Length = 369

 Score =  107 bits (267), Expect = 4e-22,   Method: Compositional matrix adjust.
 Identities = 79/259 (30%), Positives = 127/259 (49%), Gaps = 43/259 (16%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIGQH----VFTAHRLDR 55
           LEI++QD  +  +NKP+G +VH +       +V  ++  ++D  G +        HR+D+
Sbjct: 112 LEIIFQDADIAVINKPAGLVVHPAEGHWSGTLVNALLYHIKDLSGINGELRPGIVHRIDK 171

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKF 115
            TSG+L++  +  A   L +Q + H++++ Y A+V G +  E            ++    
Sbjct: 172 DTSGLLVVAKNDRAHIHLTEQVKDHRVRREYLAVVHGVIGAET----------GRVEAPI 221

Query: 116 AREDK---------GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRR 166
            R+ K         G + A+TH+R LA         RYP   + L+    +TGR HQ+R 
Sbjct: 222 GRDPKDRQRMAVIAGGKSAITHFRVLA---------RYPEQGFSLLHCRLETGRTHQIRV 272

Query: 167 HLAHLRHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDT 226
           HLAH+ HP+ GD K+G     R  A  FGL    LHA +L   HP +GEP+   A   + 
Sbjct: 273 HLAHIGHPVAGDPKYGP----RKAA--FGLTGQALHAWKLEFVHPRSGEPMRFQADPPEP 326

Query: 227 WMQALSQFGWRGLLPENER 245
           ++Q L       + P N+R
Sbjct: 327 FVQVLQAL---QMTPTNQR 342


>UniRef50_B0N6U2 Pseudouridine synthase n=5 Tax=Bacteria RepID=B0N6U2_9FIRM
          Length = 328

 Score =  107 bits (267), Expect = 4e-22,   Method: Compositional matrix adjust.
 Identities = 72/228 (31%), Positives = 115/228 (50%), Gaps = 33/228 (14%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFT------------ 49
             +LY+D+ ++ V KP+G LVH    D +E +    T+ +Q+  ++ +            
Sbjct: 90  FSVLYEDKHVLIVFKPAGLLVHE---DANESI---NTLTNQVLSYLASKNELDLSRENTF 143

Query: 50  ----AHRLDRPTSGVLLMGLSSEAGRLLAQQFEQ-HQIQKRYHAIVRGWLMEEAVLDYPL 104
                HRLDR TSG+++ G +  A + L +  +Q H I+K+Y  I RG L  +  L   +
Sbjct: 144 MPGPVHRLDRNTSGIVIFGKTLAALQNLNEMIKQRHCIEKKYLTICRGQLNHQRNLHGYM 203

Query: 105 VEELDKIADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQL 164
           ++  ++   K  ++D         Y G  T+E  V   +Y    Y LVE+   TGR HQ+
Sbjct: 204 IKLENQAQVKLVKKD---------YPGALTMETIVRPLKY-NCDYSLVEVTLITGRMHQI 253

Query: 165 RRHLAHLRHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPF 212
           R HL+ + HPIIGD K+GD   N+   + FGL   +LHA ++     F
Sbjct: 254 RVHLSSIEHPIIGDRKYGDFELNKYIKKTFGLNNQLLHAYKIKFVKTF 301


>UniRef50_A0LXI9 Pseudouridine synthase n=1 Tax=Gramella forsetii KT0803
           RepID=A0LXI9_GRAFK
          Length = 289

 Score =  106 bits (265), Expect = 7e-22,   Method: Compositional matrix adjust.
 Identities = 69/233 (29%), Positives = 111/233 (47%), Gaps = 39/233 (16%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV---VMQTVRDQIGQHVFTAHRLDRPTS 58
            E+L++DE +  V+KP G+    ++    E  +   +  +       +   AHRLD PTS
Sbjct: 80  FEVLFEDEHIAVVHKPPGFPTSGNYFKTIENALPHNLSSSSEIDTLPYPLPAHRLDNPTS 139

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           G+LL   ++ +   L + F Q QIQK Y+AIV G + E+  +D P+ +++ K        
Sbjct: 140 GILLCAKTNSSLIKLQEAFAQKQIQKTYYAIVSGEIKEKIEIDSPIDQKISK-------- 191

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
                          T+ +P+   +     Y LVEL P TGR HQLR HL+    PIIGD
Sbjct: 192 ---------------TILIPIEFYQIENKNYTLVELNPLTGRTHQLRIHLSENNTPIIGD 236

Query: 179 SKHG----DLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTW 227
           + +G    +L +N+S         + L A ++S  HP + + +T    L   +
Sbjct: 237 NLYGKEETNLLKNKS---------IYLFAGKISFDHPLSKKLMTFQLQLPKKF 280


>UniRef50_Q6MND5 Pseudouridine synthase n=1 Tax=Bdellovibrio bacteriovorus
           RepID=Q6MND5_BDEBA
          Length = 228

 Score =  106 bits (265), Expect = 8e-22,   Method: Compositional matrix adjust.
 Identities = 68/199 (34%), Positives = 113/199 (56%), Gaps = 12/199 (6%)

Query: 10  WLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLMGLSSEA 69
           WLV +NKPSG  VH      D + ++ + +     Q +   HRLD+ TSG+LL+GL +E 
Sbjct: 19  WLV-INKPSGVSVHND--PPDVRTLLKKQLTPGTYQDIHPVHRLDKETSGLLLVGLDAET 75

Query: 70  GRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKGPQPAVTHY 129
              L+ QF++H+++K Y+A++RG    E  +     E    I+DK A   K PQ  +   
Sbjct: 76  AANLSGQFQEHKVEKTYYALLRG----ELPVSTDWQEWNTPISDK-AEGRKNPQGLLKDR 130

Query: 130 RGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHGDLRQNRS 189
               T+   +   +Y    + LVE+   TGR+HQ+R+H A +RH I+GD+++GD + N  
Sbjct: 131 VEARTLYKVLEANKY----FSLVEVRLITGRQHQIRKHTALIRHAIVGDTRYGDPKYNER 186

Query: 190 GAEHFGLQRLMLHASQLSL 208
            A  +  +R+ LHA+++++
Sbjct: 187 MANIYQTKRMFLHAARMTV 205


>UniRef50_A6GP31 Pseudouridine synthase n=1 Tax=Limnobacter sp. MED105
           RepID=A6GP31_9BURK
          Length = 335

 Score =  106 bits (264), Expect = 8e-22,   Method: Compositional matrix adjust.
 Identities = 71/240 (29%), Positives = 119/240 (49%), Gaps = 12/240 (5%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           L IL++DE L+ VNKPSG  VH         +  ++ +R +  Q +   HR+DR TSG+L
Sbjct: 104 LPILFEDEHLLVVNKPSGMAVHGGSGSSFGLIECIRALRAETHQDLELVHRIDRETSGIL 163

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRG-WLMEEAVLDYPLVEELDKIADKFAREDK 120
           ++     A R L +Q      +K Y  +V G W      +D PL++      +     D+
Sbjct: 164 IISKKRSALRKLQEQLRARSWKKYYKTLVLGHWPEALRQVDLPLLKTQSSEKEARVFVDE 223

Query: 121 GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSK 180
               A T ++ +   +   ++       + L++ +  TGR HQ+R H +  + PI GD +
Sbjct: 224 SGDKACTKFKVIQCYKSSYSS-------FTLIQAQILTGRTHQIRVHTSANKFPIAGDDR 276

Query: 181 HGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLD---DTWMQALSQFGWR 237
           +G+   N+  A   GL+R+ LHA++L L HP T E + + A L    D ++++L     R
Sbjct: 277 YGNFEMNKQLARQ-GLKRMFLHAARLQLVHPATNETIVLEAPLAPELDGFLKSLQAVQSR 335


>UniRef50_C8PTH9 Ribosomal large subunit pseudouridine synthase C n=1 Tax=Treponema
           vincentii ATCC 35580 RepID=C8PTH9_9SPIO
          Length = 240

 Score =  106 bits (264), Expect = 9e-22,   Method: Compositional matrix adjust.
 Identities = 69/217 (31%), Positives = 105/217 (48%), Gaps = 38/217 (17%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           + I+Y+DE L  VNKP G  V          V + + +  Q+G  +F  HRLD+ TSG+L
Sbjct: 13  IPIVYEDEALCIVNKPYGIPVQGG---AHISVCLTEILSKQLGSEIFPVHRLDKETSGLL 69

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGW------------LMEEAVLDYPLVEELD 109
           +   S++A R     FE   ++K Y A+  G             L+ E ++D P+VE   
Sbjct: 70  VTAKSADAARSCRALFESQAVEKEYLALCFGGFEPSAHKKPVKKLLPEGIIDTPVVE--- 126

Query: 110 KIADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLA 169
                    +  P+PA + Y+ LA+           T  Y L  +   TGR HQ+R HLA
Sbjct: 127 ---------NGSPKPASSAYKLLAS-----------TDAYSLFSVRLHTGRMHQIRIHLA 166

Query: 170 HLRHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQL 206
            + +PIIGD KHG+   N+   +   +++L L A +L
Sbjct: 167 GIGYPIIGDDKHGNFALNKQLWKTARIKKLQLCAYRL 203


>UniRef50_Q8ZFU1 Ribosomal large subunit pseudouridine synthase C n=102
           Tax=Gammaproteobacteria RepID=RLUC_YERPE
          Length = 320

 Score =  106 bits (264), Expect = 9e-22,   Method: Compositional matrix adjust.
 Identities = 75/229 (32%), Positives = 113/229 (49%), Gaps = 14/229 (6%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLM 63
           IL++D++L+ +NKPSG  VH         +  ++ +R +  + +   HRLDR TSGVLL+
Sbjct: 95  ILFEDDYLLVLNKPSGTAVHGGSGLSFGVIEGLRALRPE-ARFLELVHRLDRDTSGVLLV 153

Query: 64  GLSSEAGRLLAQQFEQHQIQKRYHAIVRG-WLMEEAVLDYPLVEELDKIADKFAREDKGP 122
                A R L +Q     +QK Y A+VRG W      +  PL++ + +  ++  +     
Sbjct: 154 AKKRSALRSLHEQLRLKSMQKDYLALVRGQWQSHCKAIQAPLLKNIMQSGERVVKVSSEG 213

Query: 123 QPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHG 182
           +P+ T ++     E              LV+  P TGR HQ+R H  H  HPI  D ++G
Sbjct: 214 KPSETRFKIEERFEHAT-----------LVKASPVTGRTHQIRVHALHAGHPIAFDDRYG 262

Query: 183 DLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
             R+     +  GL RL LHA+ L   HP TGE + I A LD+     L
Sbjct: 263 -YREFDQQLQGTGLHRLFLHAAALRFEHPNTGETMRIEAPLDNQLRHCL 310


>UniRef50_A3Y8C6 Pseudouridine synthase n=1 Tax=Marinomonas sp. MED121
           RepID=A3Y8C6_9GAMM
          Length = 322

 Score =  105 bits (263), Expect = 1e-21,   Method: Compositional matrix adjust.
 Identities = 74/232 (31%), Positives = 120/232 (51%), Gaps = 17/232 (7%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLM 63
           I+Y+D  L+ VNKPSG  VH         V V++ +R +  + +   HRLDR TSG++++
Sbjct: 100 IVYEDAGLMVVNKPSGLAVHGGSGLNFGLVEVVRQLRSK-EKSIELVHRLDRDTSGLIMI 158

Query: 64  GLS-SEAGRLLAQQFEQHQIQKRYHAIVRG-WLMEEAVLDYPLVEELDKIADKFAREDKG 121
               S   +L A   E+  +QK Y A+V G W   +  ++ PL++   K  ++  +    
Sbjct: 159 SKKRSVLKQLHAALREKEGVQKTYQALVYGSWPKRKQQVNAPLLKNELKSGERIVKVHTE 218

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
            + ++T ++ L   E            Y LVE EP TGR HQ+R H  H  +PI+GD K+
Sbjct: 219 GKESLTRFKLLRQFEG-----------YSLVECEPVTGRTHQIRVHTLHAGYPIVGDDKY 267

Query: 182 GDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
               QN+  A+  G +RL LHA++L +      + + +   +DD W  A++Q
Sbjct: 268 SPSEQNKE-AKGLGFKRLCLHAAKLDIM--LNDQRILVEVPIDDEWRNAMNQ 316


>UniRef50_A9E330 Pseudouridine synthase n=1 Tax=Kordia algicida OT-1
           RepID=A9E330_9FLAO
          Length = 300

 Score =  105 bits (262), Expect = 1e-21,   Method: Compositional matrix adjust.
 Identities = 73/225 (32%), Positives = 107/225 (47%), Gaps = 34/225 (15%)

Query: 1   MLEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQ-TVRDQIGQHVFT--AHRLDRPT 57
           ++ ++++D+ +  +NKP+G+  + ++    E  +       + I    F    HRLD PT
Sbjct: 79  VISVIFEDDEIAIINKPAGFPTNGNYFKTIENALPHNLKPSNSIDALPFPKPVHRLDNPT 138

Query: 58  SGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAR 117
           SG+L++  +  A   L QQFEQ +I K Y AIV G   +E  +   + E           
Sbjct: 139 SGILIIAKTKSAQISLYQQFEQQEISKTYQAIVIGKTDKEGEITSAVAE----------- 187

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
                + A+T+Y  L TV               LV+L PKTGR HQLR HLA + HPI+G
Sbjct: 188 -----KEALTNYETLQTV------SSLQNGHLSLVKLFPKTGRTHQLRIHLASINHPIVG 236

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPL--TIH 220
           D  +G   +N           L L A+ + L HP T E L  TIH
Sbjct: 237 DQLYGKAEENYKKG-------LFLCATSIQLIHPKTKEKLVFTIH 274


>UniRef50_D0P480 Ribosomal large subunit pseudouridine synthase A, putative n=1
           Tax=Phytophthora infestans T30-4 RepID=D0P480_PHYIN
          Length = 363

 Score =  105 bits (262), Expect = 1e-21,   Method: Compositional matrix adjust.
 Identities = 81/240 (33%), Positives = 121/240 (50%), Gaps = 29/240 (12%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           L+IL++D+ ++ VNKP+  L      D D  + V + V  ++  +    HRLD+ TSG+L
Sbjct: 117 LKILFRDDAVIVVNKPANIL-SVDGTDPDALMSVHRCVA-RVYPNARMVHRLDQETSGLL 174

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAV--------LDYPLVEELDKIAD 113
           ++ L+  A + L  QF    + K Y A V GW+M +          +  P+ + L K   
Sbjct: 175 VVALTKSAAQSLNAQFRDRSVDKTYVARVDGWMMNDLEEKSESPRRVQIPMEKHLTKSLI 234

Query: 114 KFAREDKGPQPA-----VTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHL 168
           +    D+   P+      T Y  L+  E      R  T    LVEL+P TG+ HQLR H+
Sbjct: 235 QHVVSDREVDPSSSLWSTTEYSVLSRDES--GDDRKST----LVELKPVTGKTHQLRLHM 288

Query: 169 AHLRHPIIGDSKHG-DLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTW 227
            HL HPI+GDS +  D+  +R+        RL LHA++LS THP T E LT  +    T+
Sbjct: 289 QHLGHPILGDSLYSPDVVYHRAS-------RLCLHAAKLSFTHPVTNERLTFESPCPLTF 341


>UniRef50_B7FU02 Predicted protein (Fragment) n=1 Tax=Phaeodactylum tricornutum CCAP
           1055/1 RepID=B7FU02_PHATR
          Length = 240

 Score =  105 bits (262), Expect = 1e-21,   Method: Compositional matrix adjust.
 Identities = 76/239 (31%), Positives = 107/239 (44%), Gaps = 22/239 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWL-VHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGV 60
           L ILY DE +  VNKPSG L V     +     +V + +   I       HR+D  TSGV
Sbjct: 1   LHILYCDEHICVVNKPSGILSVPGPRRNPSIANLVYEILNPPIDIDQMVVHRIDMDTSGV 60

Query: 61  LLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDK 120
           L+  L+  A R L   F   +++K Y A++ G   +   ++  +  E D     F R   
Sbjct: 61  LVFALTELALRQLHDDFRSRRVKKTYEALLAGHFRKATQVEIDVALERDPYHPPFMRRYW 120

Query: 121 GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSK 180
            PQ + T+ R  + +  P A    P +R   V + P TGR HQLR H A L +PIIGD  
Sbjct: 121 EPQRSATYSRQFSQIYQPSAQAHLPVSR---VHMSPHTGRTHQLRVHAAALGYPIIGDDI 177

Query: 181 HGDLRQNRSGAEHFGLQRLM------------------LHASQLSLTHPFTGEPLTIHA 221
           +G   +   G     L +L+                  LHA QL + HPF+G P+    
Sbjct: 178 YGFEGEGDCGVNSTILDQLIPNRMSLHQQLQELQLPLCLHAKQLCIFHPFSGAPMIFEC 236


>UniRef50_C8NEP8 Pseudouridine synthase n=1 Tax=Granulicatella adiacens ATCC 49175
           RepID=C8NEP8_9LACT
          Length = 308

 Score =  105 bits (262), Expect = 1e-21,   Method: Compositional matrix adjust.
 Identities = 72/231 (31%), Positives = 118/231 (51%), Gaps = 36/231 (15%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVM-----QTVRDQIGQHVF---TAHRL 53
           L+I+++D+ L+ VNKPSG +VH S       +V        ++ D   + ++     HR+
Sbjct: 80  LDIVFEDDSLIVVNKPSGMVVHPSKGHYSGTLVNALLYHSNSLSDSTSEEIYRPGLVHRI 139

Query: 54  DRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRG-WLMEEAVLDYPL----VEEL 108
           D+ TSG+L++  +++  + LA+Q  ++++ + Y AIV G +  E  V+D PL       L
Sbjct: 140 DKDTSGLLVIAKNNDVHQKLAEQIAENKMNREYIAIVDGHFAHETGVVDAPLSRHQTNRL 199

Query: 109 DKIADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHL 168
            ++       +KG + A+TH+  L +            + Y LV    +TGR HQ+R H+
Sbjct: 200 KRVV------EKGGKNAITHFEVLDSF-----------SDYSLVSCRLETGRTHQIRAHM 242

Query: 169 AHLRHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTI 219
             ++HPI+ D  +    +N   A  FG     LHA  LS THP TGE L  
Sbjct: 243 EFIKHPIVNDPLYHPKGKN---ATEFG---QFLHARTLSFTHPLTGETLNF 287


>UniRef50_D1W0M0 Pseudouridine synthase n=1 Tax=Prevotella timonensis CRIS 5C-B1
           RepID=D1W0M0_9BACT
          Length = 566

 Score =  105 bits (262), Expect = 2e-21,   Method: Compositional matrix adjust.
 Identities = 82/228 (35%), Positives = 116/228 (50%), Gaps = 36/228 (15%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHV--FTAHRLDRPTSG 59
           L ++Y+D+ L+ V+KP+G L   S   R ++  V   +R Q+   V  F+ HRLD  TSG
Sbjct: 351 LHVVYEDDALIVVDKPAGIL---SVPGRSQRPSVYSILRSQMPSSVELFSVHRLDMATSG 407

Query: 60  VLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADKFARE 118
           +L++  +S   R L +QF  H IQK Y AI+ G L + E V+  PL  +      +    
Sbjct: 408 LLILAKNSVVYRHLQRQFRTHHIQKEYIAILEGALSQREGVVTLPLRPDPFDRPRQVVDW 467

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGL--VELEPKTGRKHQLRRHLAH---LRH 173
           + G + AVT YR L               R+G   V L P+TGR HQLR H AH   L  
Sbjct: 468 EHG-KKAVTSYRVL-------------NVRHGKTWVALFPETGRTHQLRMHCAHAEGLNC 513

Query: 174 PIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHA 221
           PI+GD  +G               RL LHA+ ++  HP +G+ LT+HA
Sbjct: 514 PILGDPLYGH-----------HANRLYLHATSITFEHPISGQLLTLHA 550


>UniRef50_B9Y836 Pseudouridine synthase n=3 Tax=Firmicutes RepID=B9Y836_9FIRM
          Length = 307

 Score =  105 bits (261), Expect = 2e-21,   Method: Compositional matrix adjust.
 Identities = 74/240 (30%), Positives = 122/240 (50%), Gaps = 26/240 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIGQHVF----TAHRLDR 55
           L ++Y+D  ++ +NKP G +VH    + D  +V  ++    D  G +        HR+D+
Sbjct: 80  LNVVYEDHDVIVINKPKGLVVHPGPGNPDHTLVNGLLWHCHDLSGINGVLRPGIVHRIDK 139

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADK 114
            TSG+++   +  A + LA+Q  +    ++Y+A+V G +  E   +D P+  + +K   K
Sbjct: 140 DTSGLIVACKNDNAHQSLAKQLAEKTAGRQYYALVHGVINHEYGTIDAPIGRD-EKDRQK 198

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
            A  +K  +PA+TH++ +   +            Y LV    +TGR HQ+R H+ ++  P
Sbjct: 199 MAVTEKNSRPAITHFKVVERFD-----------NYTLVSCRLETGRTHQIRVHMQYIGFP 247

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           I+GD K+  LR+          Q  MLHA QLS THP TGE +T  A L   +   L+Q 
Sbjct: 248 IVGDPKYS-LRKT------LPTQGQMLHAYQLSFTHPSTGERMTFEAPLPPEFEALLTQL 300


>UniRef50_Q126H9 Pseudouridine synthase n=1 Tax=Polaromonas sp. JS666
           RepID=Q126H9_POLSJ
          Length = 378

 Score =  104 bits (259), Expect = 3e-21,   Method: Compositional matrix adjust.
 Identities = 79/239 (33%), Positives = 118/239 (49%), Gaps = 11/239 (4%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLM 63
           +L++D++L+A++KP+G  VH         +  ++  R Q    +   HRLDR TSG+LL+
Sbjct: 128 VLFEDDFLLAIDKPAGVAVHGGSGVSFGVIEQLRMARPQ-ADFLELVHRLDRETSGILLI 186

Query: 64  GLSSEAGRLLAQQFEQHQIQKRYHAIVRG-WLMEEAVLDYPLVEEL--DKIADKFAREDK 120
                A +LL +QF + +  K Y A+V G W     V+D  L + L      +   R   
Sbjct: 187 AKRRMALKLLQEQFRERETDKVYLALVSGNWPANHRVIDKALHKYLLPGGAGEGERRVKV 246

Query: 121 GPQPAVTHYRGLATVEMPVATGRYPT---TRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
            P       R +  V++  A    P    T + L+E+  KTGR HQ+R HLA+  HPI G
Sbjct: 247 VPNDHPDGMRSVTLVKVKSAFAALPAAPGTPFTLLEVTIKTGRTHQIRVHLANEGHPIAG 306

Query: 178 DSKHGDLRQNRSGAEHFG----LQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALS 232
           D K+GD   N+S  +       L+R+ LHA  L   HP T + + +   L D   Q LS
Sbjct: 307 DDKYGDFELNKSLQKSVAGGAPLKRMFLHAWSLKFNHPKTRKTIHLETPLPDELQQFLS 365


>UniRef50_Q6FCX9 Pseudouridine synthase n=1 Tax=Acinetobacter sp. ADP1
           RepID=Q6FCX9_ACIAD
          Length = 214

 Score =  104 bits (259), Expect = 3e-21,   Method: Compositional matrix adjust.
 Identities = 72/218 (33%), Positives = 116/218 (53%), Gaps = 16/218 (7%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLM 63
           ++++D   + ++KP+G L      D     ++++ V  +I       HRLDR TSG+L+ 
Sbjct: 9   LIHRDNDFMVIHKPAGILSVPGKGDALFDSLLVRLV--EIEPKTLLIHRLDRDTSGILVF 66

Query: 64  GLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKGPQ 123
           GL+  A   +++QF++ Q  K Y A+V G +  E ++D P+V +  +     A +    +
Sbjct: 67  GLNKMAQSAISRQFQERQTDKIYQALVVGEVYGEGLIDVPVVYDAARPPLHIA-DPAHHK 125

Query: 124 PAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHGD 183
           PA T ++ L   E+    G+  T     + L P TGR HQLR H+ ++ HPI+GD+ +  
Sbjct: 126 PAQTEWQALEQFEL---NGKMVTR----MRLTPITGRSHQLRVHMQYIGHPIVGDTLYAS 178

Query: 184 LRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHA 221
           L      A+   + RL LHA QLS  HP TGE +T H 
Sbjct: 179 L------ADQQLVSRLCLHAEQLSFYHPKTGELVTFHC 210


>UniRef50_Q1J0S8 Pseudouridine synthase n=7 Tax=Deinococci RepID=Q1J0S8_DEIGD
          Length = 341

 Score =  104 bits (259), Expect = 3e-21,   Method: Compositional matrix adjust.
 Identities = 92/262 (35%), Positives = 124/262 (47%), Gaps = 31/262 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQ----TVRDQIGQ------HVFTAH 51
           L++LY+DE L+AVNKP G + H +       +V       T+ +Q G            H
Sbjct: 97  LDVLYEDEHLIAVNKPPGMVTHPAPGVTSGTLVNALLGRLTLPEQPGAVGPDGYRPGIVH 156

Query: 52  RLDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRG-WLMEEAVLDYPLVEELDK 110
           RLD+ TSGV+++  + EA   LA  F+     K Y AI  G W  +  V     V     
Sbjct: 157 RLDKDTSGVIVVAKTVEAHARLAAAFKDRSTHKTYLAIAAGMWKAQGPVSVNAPVGRHPT 216

Query: 111 IADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAH 170
              +      GP+ A T +  LAT   P   GR       LV  +P TGR HQ+R HLAH
Sbjct: 217 ARQRMTVGGVGPREAQTLFTPLAT--HPDGHGRT----LALVRAQPHTGRTHQIRVHLAH 270

Query: 171 LRHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQA 230
           L  PI+GD+ +G     R+ A    + R  LHA  L+L HP TGE L +HA + D  ++A
Sbjct: 271 LGSPILGDAVYG-----RASAV---MPRHALHAQFLTLPHPVTGETLHLHAPVPDDLLRA 322

Query: 231 LSQFGWRGLLPENERVEFSAPS 252
               G  G +P     E  APS
Sbjct: 323 WVALG--GAVP----AELEAPS 338


>UniRef50_P44433 Ribosomal large subunit pseudouridine synthase C n=22
           Tax=Gammaproteobacteria RepID=RLUC_HAEIN
          Length = 322

 Score =  104 bits (259), Expect = 3e-21,   Method: Compositional matrix adjust.
 Identities = 78/232 (33%), Positives = 117/232 (50%), Gaps = 15/232 (6%)

Query: 3   EILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLL 62
           +IL++D+ L+ +NKPSG  VH         +  ++ +R +  + +   HRLDR TSG+LL
Sbjct: 99  QILFEDDCLIILNKPSGIAVHGGSGLNFGVIEALRALRPE-ARFLELVHRLDRDTSGILL 157

Query: 63  MGLSSEAGRLLAQQFEQHQIQKRYHAIVRG-WLMEEAVLDYPLVEELDKIADKFAREDKG 121
           +     A R L +Q     +QK Y A+VRG W     V+   L++      ++  R  + 
Sbjct: 158 IAKKRSALRNLHEQLRVKTVQKDYLALVRGQWQSHIKVIQASLLKNELSSGERIVRVSEQ 217

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
            +P+ T +    ++E      RY      LV+  P TGR HQ+R H  +  HPI  D K+
Sbjct: 218 GKPSETRF----SIE-----ERYINA--TLVKASPVTGRTHQIRVHTQYAGHPIALDDKY 266

Query: 182 GDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           GD   ++   E  GL RL LHA  +   HP  GE L  +A LD   M+A+ Q
Sbjct: 267 GDKDFDKQMNE-LGLNRLFLHAFSIRFEHPKNGETLRFNASLDH-QMKAILQ 316


>UniRef50_D2RBY1 Pseudouridine synthase, RluA family n=1 Tax=Gardnerella vaginalis
           409-05 RepID=D2RBY1_GARVA
          Length = 321

 Score =  104 bits (259), Expect = 3e-21,   Method: Compositional matrix adjust.
 Identities = 75/235 (31%), Positives = 123/235 (52%), Gaps = 38/235 (16%)

Query: 2   LEILYQDEWLVAVNKPSGWLVH--RSW-----------LDRDEKVVVMQTVRDQIGQHVF 48
           + I+Y D+ +V ++KP G   H  + W           +  D K  +    R  I     
Sbjct: 92  IPIIYNDDDVVVIDKPVGVASHAAKGWSGPTVPECLEAVGIDIKTTLCDESRKGI----- 146

Query: 49  TAHRLDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEE 107
              RLD  TSG++L+  +  A  ++  QF +H ++K YHA+V+G L ++ A +D P+   
Sbjct: 147 -VSRLDVGTSGLMLVCKTDFAYEVMKNQFAKHIVKKTYHALVQGDLAQDKATIDAPIGRA 205

Query: 108 LDKIAD-KFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRR 166
             K++D +F     G +PAVTH+  L          R+  ++  LV +  +TGR HQ+R 
Sbjct: 206 --KVSDFRFTITSDG-KPAVTHWDVLE---------RF--SQATLVSVNLETGRTHQIRV 251

Query: 167 HLAHLRHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHA 221
           H + + HP++GDS +G    N   A+  GLQR  LH+ +L+ THP TG+ +T+ +
Sbjct: 252 HFSSIGHPLVGDSMYG---ANPVLAQKLGLQRQWLHSMELTFTHPRTGKSVTVKS 303


>UniRef50_Q73K15 RNA pseudouridylate synthase family protein n=1 Tax=Treponema
           denticola RepID=Q73K15_TREDE
          Length = 244

 Score =  104 bits (259), Expect = 4e-21,   Method: Compositional matrix adjust.
 Identities = 74/238 (31%), Positives = 122/238 (51%), Gaps = 31/238 (13%)

Query: 1   MLEILYQDEWLVAVNKPSGWLVHRSWLDRDE---KVVVMQTVRDQIGQHVFTAHRLDRPT 57
           + EILY+D+ ++ VNK +G LV     D +      ++ +  +D+  + ++  HRLD+ T
Sbjct: 5   LYEILYEDKDILIVNKNAGLLVGADRWDSEAPRLDKILEELYKDKGERKIYPVHRLDKET 64

Query: 58  SGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAR 117
           SG+++  L++EA + L   F+  +I+K YHA+  G   EE   ++   E+L    DK  R
Sbjct: 65  SGLIIYALNAEAHKTLNDDFQNRKIEKIYHAVSAGIPQEE---NFKAEEKLRIDGDKLHR 121

Query: 118 ---EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
              ++K  + ++T +  L              +R+ L+E  P TGR HQ+R HL HL  P
Sbjct: 122 TVIDEKKGKESLTEFSLLKRF-----------SRFCLLEARPITGRTHQIRAHLKHLGLP 170

Query: 175 IIGDSKHGD--------LRQNRSG---AEHFGLQRLMLHASQLSLTHPFTGEPLTIHA 221
           I+ D+ +G+        L++N  G    E   + RL LHA  L   HP + E + I A
Sbjct: 171 ILCDNLYGNGEPVYISALKKNWRGDKYEERPIISRLALHAHSLKFFHPISKEKIEISA 228


>UniRef50_Q1PXB6 Pseudouridine synthase n=1 Tax=Candidatus Kuenenia stuttgartiensis
           RepID=Q1PXB6_9BACT
          Length = 274

 Score =  103 bits (258), Expect = 5e-21,   Method: Compositional matrix adjust.
 Identities = 72/231 (31%), Positives = 119/231 (51%), Gaps = 38/231 (16%)

Query: 3   EILYQDEWLVAVNKPSGWLVH-RSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           +IL+ D+  V V+KP G + + ++ ++RD +    Q  RD+I       HRLD+ TSG L
Sbjct: 75  DILFNDDCYVIVSKPPGIVTNGQNSIERDLRT---QFNRDRIQ----AVHRLDKDTSGAL 127

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEA-VLDYPLVEELDKIADKFAREDK 120
           +   +  A   + + F++H IQK Y  IV G + E A  ++ P+                
Sbjct: 128 IFAKNENAFEEMKKVFKKHDIQKIYRVIVTGKICEPAFTINSPV---------------- 171

Query: 121 GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSK 180
           G Q AVTH   L          +   T Y  +E+  +TGR+HQ+R HLA + HP+IG+++
Sbjct: 172 GGQTAVTHITLLK---------KGKNTSY--LEVATETGRRHQIRIHLASIGHPVIGETE 220

Query: 181 HGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
           +   R+      H   +R MLHA ++S  HP+T + +++ A +   ++Q L
Sbjct: 221 YA--RKEIENILHREAKRQMLHAHRISFVHPYTKKEISVTAPISHDFIQCL 269


>UniRef50_C8PQT2 Ribosomal large subunit pseudouridine synthase D n=1 Tax=Treponema
           vincentii ATCC 35580 RepID=C8PQT2_9SPIO
          Length = 246

 Score =  103 bits (258), Expect = 5e-21,   Method: Compositional matrix adjust.
 Identities = 77/237 (32%), Positives = 119/237 (50%), Gaps = 29/237 (12%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIG---QHVFTAHRLDRP 56
             ++Y D+ +VAVNK +G LV     D +   +  ++Q    QI      ++  HR+D+ 
Sbjct: 6   FTLIYADDDMVAVNKAAGLLVAADRWDAEAPRLDLLIQKELPQIAPSCNKLYAVHRIDKD 65

Query: 57  TSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEA-VLDYPLVEELDKIADKF 115
           TSG+LL  L++EA R L   F+  +I+K Y  ++ G + EE   +D PL  + D +    
Sbjct: 66  TSGILLYALNAEAHRTLNTAFQNREIKKTYRLLIHGRVSEEQFTVDLPLRADGDALHRTV 125

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
             + +G + AVTH+  L T             ++ L+E  P TGR HQ+R HLA   +PI
Sbjct: 126 VDKRRGKE-AVTHFTVLETFR-----------QFSLLEACPVTGRTHQIRAHLAAAGYPI 173

Query: 176 IGDSKHG--------DLRQNRSG---AEHFGLQRLMLHASQLSLTHPFTGEPLTIHA 221
           + DS +G        +L+Q   G    E   + RL LHA +L   HP +G+P    A
Sbjct: 174 VCDSLYGSGKPVLLSELKQRWRGDVYTEQPLIGRLALHAYRLEGVHPRSGQPFAFTA 230


>UniRef50_Q0AFD5 Pseudouridine synthase n=3 Tax=Nitrosomonas RepID=Q0AFD5_NITEC
          Length = 354

 Score =  103 bits (257), Expect = 5e-21,   Method: Compositional matrix adjust.
 Identities = 84/237 (35%), Positives = 114/237 (48%), Gaps = 27/237 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFT--AHRLDRPTSG 59
            + LYQD++L+ +NKP+G  VH           V++ +R Q     F    HRLDR TSG
Sbjct: 116 FDTLYQDDYLLVINKPAGTAVHGG---SGISYGVIEQLRKQRPDWKFLELVHRLDRETSG 172

Query: 60  VLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRG-WLMEEAVLDYPLVEELD-----KIAD 113
           VLL+    +    L +Q  +  ++K Y  +VRG W      +  PL + L      ++A 
Sbjct: 173 VLLLARKRQTLLELHKQIREGTVRKHYLTLVRGKWKNSLQNVRLPLYKYLTAEGERRVAI 232

Query: 114 KFAREDKGP-QPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLR 172
              R D    Q A T +      E            + L++ E KTGR HQ+R HLAHL 
Sbjct: 233 ATGRNDHDKVQQAYTLFALQKNWEA-----------FSLLDAELKTGRTHQIRVHLAHLG 281

Query: 173 HPIIGDSKHGDLRQNRSGAEHFG----LQRLMLHASQLSLTHPFTGEPLTIHAGLDD 225
            PI GD K+GD   NR   +  G    L+R+ LHAS    THP TGE L + A L D
Sbjct: 282 FPIAGDDKYGDFGLNRQLQKDDGSGLVLKRMFLHASVFVCTHPVTGELLRLEAPLPD 338


>UniRef50_D2R4N0 Pseudouridine synthase, RluA family n=1 Tax=Pirellula staleyi DSM
           6068 RepID=D2R4N0_9PLAN
          Length = 313

 Score =  103 bits (257), Expect = 5e-21,   Method: Compositional matrix adjust.
 Identities = 73/227 (32%), Positives = 127/227 (55%), Gaps = 25/227 (11%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQI-----GQHVFTAHRLDRPTS 58
           I+Y+D  L+ V KP+  L   +   ++++  +++ V + +     G+  F  HRLDR  S
Sbjct: 89  IVYEDRHLIVVEKPAALLTVPT--PKNDRGTLLERVANYVKIVSRGKGAFQVHRLDRGVS 146

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADKFAR 117
           G+L+ G ++E  ++L  QF  H+ ++ Y AIVRG L + E +++  L  + D   ++++ 
Sbjct: 147 GLLIFGKTTELAQMLRDQFAMHKPEREYVAIVRGKLDKPEGMIESFLATDRD--LNRYST 204

Query: 118 EDKG-PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPII 176
           +D+   Q AVTHYR +   E+  A+         +V++  +TGR++Q+R H A   HP+I
Sbjct: 205 DDESIGQHAVTHYRVIE--ELAGAS---------VVQVWLETGRRNQIRVHFAEAGHPLI 253

Query: 177 GDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGL 223
           GD ++   R + +    +   R+ LHA  L L+HP TGEPL   + L
Sbjct: 254 GDQRY---RADEAADTRWTHARIALHARLLGLSHPMTGEPLRFESPL 297


>UniRef50_A6LDZ7 Pseudouridine synthase n=26 Tax=Bacteroidales RepID=A6LDZ7_PARD8
          Length = 549

 Score =  103 bits (257), Expect = 5e-21,   Method: Compositional matrix adjust.
 Identities = 77/222 (34%), Positives = 109/222 (49%), Gaps = 28/222 (12%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           L+ILY+D++L+ +NKP G L      D D     +  +  +    +   HRLD  TSG+L
Sbjct: 340 LDILYEDDYLLVINKPEGMLSVPGKGDADSVYQRLSILYPEATGPIIV-HRLDMATSGLL 398

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADKFAREDK 120
           L   + EA + L  QF+   IQKRY A++ G +  +E  +  PL  +      +   E+ 
Sbjct: 399 LAAKTKEAHQNLQAQFKNRTIQKRYIALLEGEVPQDEGEIRLPLCPDPLDRPRQIVSEEF 458

Query: 121 GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAH---LRHPIIG 177
           G +PA+THYR L             T+   L+   P+TGR HQLR H AH   L  PI+G
Sbjct: 459 G-KPALTHYRVLER-----------TSGKTLIAFYPQTGRTHQLRVHAAHPLGLHCPILG 506

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTI 219
           D  +G              +RL LHA  L+ THP T E + I
Sbjct: 507 DELYGR-----------KAERLYLHAEYLAFTHPITSERIEI 537


>UniRef50_D2R7T3 Pseudouridine synthase, RluA family n=1 Tax=Pirellula staleyi DSM
           6068 RepID=D2R7T3_9PLAN
          Length = 355

 Score =  103 bits (257), Expect = 6e-21,   Method: Compositional matrix adjust.
 Identities = 85/235 (36%), Positives = 115/235 (48%), Gaps = 23/235 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRS---WLDRDEKVVVM--QTVRDQIGQH-VFTAHRLDR 55
           L+IL++DE L+AVNKP G +VH +   W       +    Q +    GQH     HRLDR
Sbjct: 115 LDILFEDEHLIAVNKPPGMVVHPARGHWSGTLTSALAFHFQQLSTVGGQHRPGIVHRLDR 174

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADK 114
            TSGV+++  +      LA QF      K Y AI  G    +  V+  P+          
Sbjct: 175 DTSGVIIVAKTDPVHFSLAAQFADRTTAKEYFAITAGVPDRDRDVVSQPIG------IHP 228

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
           F RE    +P  +  R   T  M     R+   ++  VE  PKTGR HQ+R HLAH+R P
Sbjct: 229 FHREKMAIRPGHSTSRDAET--MFHVLERF--AQHAAVECLPKTGRTHQIRVHLAHVRTP 284

Query: 175 IIGDSKHG---DLRQN---RSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGL 223
           ++ D  +G   ++ Q    R G+    L R  LHA +LS+ HP TGE LTI A L
Sbjct: 285 VLCDKLYGGRAEITQGELVRDGSTEVVLNRQALHARKLSINHPKTGERLTIEAPL 339


>UniRef50_A6NQQ9 Pseudouridine synthase n=1 Tax=Bacteroides capillosus ATCC 29799
           RepID=A6NQQ9_9BACE
          Length = 300

 Score =  103 bits (256), Expect = 8e-21,   Method: Compositional matrix adjust.
 Identities = 79/226 (34%), Positives = 111/226 (49%), Gaps = 24/226 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKV--VVMQTVRDQ-IGQHVFTAHRLDRPTS 58
           L+I+YQD+ ++ +NK  G  VH       + +   +M   R Q I       HRLDR TS
Sbjct: 84  LDIVYQDQDVLVLNKAPGVAVHPGPGHYSDTIGNFLMDYYRKQGILADFHPVHRLDRGTS 143

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEA-VLDYPLVEELDKIADKFAR 117
           G+LL+ L   A  +L +Q      ++ Y A+  G     + V+D P+      +  +  R
Sbjct: 144 GLLLVALHGHAQEVLKEQLHSPSFRRVYLAVCEGAPNPPSGVIDAPIGRLEGSVLARTVR 203

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
            D   Q AVTHYR L TV               LV LE +TGR HQ+R H+AHL HP+ G
Sbjct: 204 PDG--QRAVTHYRTLRTVN-----------DRALVRLELETGRTHQIRVHMAHLGHPLTG 250

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGL 223
           D  +G   Q+        + R  LHA++LS THP TG+ +   A L
Sbjct: 251 DFLYGTEDQSL-------IPRPALHAAELSFTHPITGKTMAFTAPL 289


>UniRef50_C5S931 Pseudouridine synthase n=2 Tax=Gammaproteobacteria
           RepID=C5S931_CHRVI
          Length = 346

 Score =  103 bits (256), Expect = 8e-21,   Method: Compositional matrix adjust.
 Identities = 82/235 (34%), Positives = 121/235 (51%), Gaps = 16/235 (6%)

Query: 4   ILYQDEWLVAVNKPSGWLVHR-SWLDRDEKVVVMQTVRD-QIGQHVFTAHRLDRPTSGVL 61
           I+++DE L+ ++KPSG  VH  S L       +++++R  + G+ +   HRLDR TSG L
Sbjct: 122 IIHEDERLLVIDKPSGLAVHGGSGLSYG----LIESLRQLRPGRELELVHRLDRDTSGCL 177

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADKFARED- 119
           ++     A R L     +  + KRY A++ G L   E ++D PL + +    ++  R D 
Sbjct: 178 VVCKRRSALRELHALIREGGLDKRYLALILGELPRAELLVDAPLKKNVLSSGERLVRVDA 237

Query: 120 KGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDS 179
           +G + A T +R L    +    G+  T    LVE E  TGR HQ+R H AHL  P+ GD 
Sbjct: 238 QGGKEARTRFRRLKRFAI---DGQALT----LVEAELITGRTHQIRVHAAHLGTPLAGDD 290

Query: 180 KHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           K+GD   N+   + +GL+RL LHAS LS        PL +   L D   Q L   
Sbjct: 291 KYGDEAANQR-LKGYGLKRLFLHASALSFKLECMARPLRLECPLPDELQQVLDAL 344


>UniRef50_Q489H0 Pseudouridine synthase n=3 Tax=Gammaproteobacteria
           RepID=Q489H0_COLP3
          Length = 567

 Score =  102 bits (255), Expect = 9e-21,   Method: Compositional matrix adjust.
 Identities = 85/236 (36%), Positives = 110/236 (46%), Gaps = 50/236 (21%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHV--FTAHRLDRPTSG 59
           LEI++QDE +V VNKP+G L   S   +  K  V   ++ Q  Q       HRLD  TSG
Sbjct: 364 LEIVFQDEHVVVVNKPAGLL---SVPGKSIKDSVYTRIKTQFPQASGGLIVHRLDMATSG 420

Query: 60  VLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEA-VLDYPLVEELDKIADKFARE 118
           +L++ L+  A + L QQF   +I KRY A + G L + +  +  PL  + D   D+    
Sbjct: 421 LLMLALNERAHKHLQQQFMNKEINKRYVATIEGKLEKTSGEICLPLRGDFD---DR---- 473

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVE---------LEPKTGRKHQLRRHLA 169
              P+  V H             G+Y  T + L+E         L P TGR HQLR H A
Sbjct: 474 ---PKQMVCHEH-----------GKYAETHWQLIEEVDNTSKLFLYPITGRTHQLRMHCA 519

Query: 170 H---LRHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAG 222
           H   L  PIIGDS +G               RL LHA +LS THP T E LT    
Sbjct: 520 HPDGLNLPIIGDSLYG-----------HSADRLHLHAQRLSFTHPITKELLTFEVA 564


>UniRef50_B8DF66 Pseudouridine synthase n=18 Tax=Listeria RepID=B8DF66_LISMH
          Length = 289

 Score =  102 bits (255), Expect = 9e-21,   Method: Compositional matrix adjust.
 Identities = 78/234 (33%), Positives = 113/234 (48%), Gaps = 30/234 (12%)

Query: 2   LEILYQDEWLVAVNKPSGWLVH-RSWLDRDEKVVVMQTVRDQIGQ--HVFTAHRLDRPTS 58
           LEI+Y+D++L+ VNKP     H     + D     +Q   ++ GQ  +    HRLD+ TS
Sbjct: 78  LEIIYEDDFLLVVNKPVDMKTHANDSYETDTCANAVQYYLEKTGQDANALAVHRLDQTTS 137

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRG-WLMEEAVLDYPLVEELDKIADKFAR 117
           G++L   +  A   L+ Q E   I + Y A V G W +    ++ P+ E+        +R
Sbjct: 138 GLVLFAKNKLAIAGLSWQMENRAIHRTYLAAVDGTWGLVMQTINKPIGED----RHHGSR 193

Query: 118 EDKGP--QPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
               P  QPAVTH + L                  LVE + +TGR HQ+R HL+ + HPI
Sbjct: 194 RQISPYGQPAVTHVKVLENDN---------EKNTSLVECQIETGRTHQIRVHLSGIGHPI 244

Query: 176 IGDSKH-GDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWM 228
           IGD+ + G  R N          R+MLHA +L L HPF G+ +   A   D W+
Sbjct: 245 IGDTLYGGSPRAN----------RIMLHAEKLHLNHPFKGKEMNFSAPAGDDWV 288


>UniRef50_D2QJH0 Pseudouridine synthase, RluA family n=3 Tax=Bacteria
           RepID=D2QJH0_9SPHI
          Length = 308

 Score =  102 bits (255), Expect = 9e-21,   Method: Compositional matrix adjust.
 Identities = 70/239 (29%), Positives = 115/239 (48%), Gaps = 30/239 (12%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEK---VVVMQTVRDQIGQHVFTAHRLDRPTS 58
           L ILY+D++L+ +NK +G L   +  +RD     ++   T ++     +F  HRLDR TS
Sbjct: 89  LTILYEDQFLIVINKQAGLLSMATNKERDRTAYGILSEYTKKENPKNKIFIIHRLDRETS 148

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           GV++   S +  RL+ + +     ++ Y A+V G           + E        + RE
Sbjct: 149 GVMMFAKSEKVQRLMQESWNATTKERTYVALVEG-----------IPEPPQGTITSYLRE 197

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTR----YGLVELEPKTGRKHQLRRHLAHLRHP 174
            K    A+  Y         ++   Y  T+    Y L+ELE +TGRK+Q+R H+  + HP
Sbjct: 198 SK----ALIVYSSQNPDTGQLSITNYTVTKTGNGYALLELELETGRKNQIRVHMQDIGHP 253

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           + GD K+        GAE   + RL LHA  L+  HP TG P+   A +  +++  + +
Sbjct: 254 VAGDEKY--------GAESDPIGRLGLHAEVLAFEHPITGVPMRFDAPIPKSFLAMVKE 304


>UniRef50_A3MZ33 Pseudouridine synthase n=9 Tax=Proteobacteria RepID=A3MZ33_ACTP2
          Length = 237

 Score =  102 bits (255), Expect = 1e-20,   Method: Compositional matrix adjust.
 Identities = 84/229 (36%), Positives = 119/229 (51%), Gaps = 31/229 (13%)

Query: 1   MLEILYQDEWLVAVNKPSGWLVHRSWLDRDEKV-VVMQTVRDQIGQHVFT--AHRLDRPT 57
            L  +Y+D  ++ +NKPSG L      +R E     M  V+ + G   FT  AHRLD  T
Sbjct: 28  FLTEVYRDNHILVINKPSGLLSVPG--NRPEYYDSAMTRVQQKYG---FTEPAHRLDMAT 82

Query: 58  SGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEA----VLDYPLVEELDKIAD 113
           SG+LL  LS  A + L +QF   + +K Y A++ G L E+      +++PL+ + +    
Sbjct: 83  SGILLFALSKAAEKELKRQFRDREPKKHYIALLWGKLGEKVGDTGEMNFPLICDWENRPR 142

Query: 114 KFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
           +    ++G + A+THY  LA   +P  T R        V+L P TGR HQLR H   L H
Sbjct: 143 QKICYERG-KKAITHYEVLA--HLPNNTTR--------VKLTPITGRSHQLRVHSLALGH 191

Query: 174 PIIGDSKHGD-LRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHA 221
           PI+GD  +   L ++ S        RL LHA  LS+THP TGE +T  A
Sbjct: 192 PILGDKFYASPLAKSLS-------PRLCLHAESLSITHPITGEAMTFTA 233


>UniRef50_Q6MEZ4 Pseudouridine synthase n=1 Tax=Candidatus Protochlamydia
           amoebophila UWE25 RepID=Q6MEZ4_PARUW
          Length = 243

 Score =  102 bits (255), Expect = 1e-20,   Method: Compositional matrix adjust.
 Identities = 72/233 (30%), Positives = 114/233 (48%), Gaps = 22/233 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           ++ILY+D  L  + KPSG L   +  ++ E    +     +  + VF  HRLD+ TSGV+
Sbjct: 32  IQILYEDADLAIIYKPSGLLSVATAFEKGETTHALLKAHYK-PRKVFVVHRLDQDTSGVM 90

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADKFAREDK 120
           +   + +    L   FE H I + Y AIV G L+         L E+      +   E  
Sbjct: 91  VFAFNEKTCNGLKDLFEVHDISRSYTAIVEGQLLSPSGTWKSYLYEDSQYFVHETEDETY 150

Query: 121 GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSK 180
           G + A+THYR L T++           +Y LVEL  +TGRK+Q+R H     HP++GD K
Sbjct: 151 G-RLAITHYRTLKTLK-----------KYSLVELTLETGRKNQIRVHCQSAGHPVVGDKK 198

Query: 181 HGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           +        GA    L+RL LHA  L+  HP + + + I + + + + + + +
Sbjct: 199 Y--------GAHTNPLKRLCLHAHLLAFKHPISRKIIRIESPIPEEFYRLIPK 243


>UniRef50_A6ESW1 Pseudouridine synthase n=1 Tax=unidentified eubacterium SCB49
           RepID=A6ESW1_9BACT
          Length = 300

 Score =  102 bits (254), Expect = 1e-20,   Method: Compositional matrix adjust.
 Identities = 68/223 (30%), Positives = 112/223 (50%), Gaps = 31/223 (13%)

Query: 2   LEILYQDEWLVAVNKPSGWLV---HRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTS 58
           L++L++D  L  ++KP+G  V    +  ++     ++ ++ +         AHRLD PTS
Sbjct: 87  LKVLFEDNHLAIIHKPAGVEVSGNKKYTIENALPSLLKKSNQKDALDRPLPAHRLDYPTS 146

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           G LL+G +SE  + L + FE+ +I K+Y A+  G  + E  +D P+             +
Sbjct: 147 GCLLIGKTSETLQALHRMFEKREISKKYIAVTLGNQITEGKIDKPI-------------D 193

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
           DK    ++T ++ L T    + + +Y      LV L P TGR+HQLR+H+  L +PI G+
Sbjct: 194 DKA---SLTTFKTLQT----ITSKKY--NALNLVLLTPHTGRRHQLRKHMMQLGNPIFGE 244

Query: 179 SKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHA 221
             +GD+     G+       L LHA  LS  HP   + L I +
Sbjct: 245 KTYGDINDQGKGSG------LFLHAIALSFKHPIDNKTLIIKS 281


>UniRef50_C1F7V3 Pseudouridine synthase n=1 Tax=Acidobacterium capsulatum ATCC 51196
           RepID=C1F7V3_ACIC5
          Length = 355

 Score =  102 bits (254), Expect = 1e-20,   Method: Compositional matrix adjust.
 Identities = 75/260 (28%), Positives = 129/260 (49%), Gaps = 37/260 (14%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHR------SWLDRDEKVVVMQTVRDQIGQ-----HVFTA 50
           L+I+Y+D+ L+ VNKP+G +VH       S  +R   V  +   ++++ +          
Sbjct: 104 LDIIYEDKDLIVVNKPAGMMVHAGSGATDSARNRGTLVNALLGRQEKLSKTGGDLRPGIV 163

Query: 51  HRLDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELD 109
           HRLD+ TSG++++  +  A + LA+ F Q +I K Y A+V G + E+   ++  +  ++ 
Sbjct: 164 HRLDKETSGLIIVARNDAAHQRLAEMFSQREIHKTYLALVHGHIAEDRGTINAAIARDVI 223

Query: 110 KIADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYG---LVELEPKTGRKHQLRR 166
           +      R  +G + A++HYR    +E          TR+G   LV +  +TGR HQ+R 
Sbjct: 224 RRTRMTTRRTEGARTAISHYRVQRRIE----------TRWGKFTLVSVRIETGRTHQIRV 273

Query: 167 HLAHLRHPIIGDSKHG------------DLRQNRSGAEHFGLQRLMLHASQLSLTHPFTG 214
           HL+ + HP++GD+ +G              R+     E   L R  LHA++L   HP + 
Sbjct: 274 HLSSIGHPVVGDTHYGAPTTIVLPVANRARRKQLPAPEGLSLPRNFLHAAELKFPHPRSE 333

Query: 215 EPLTIHAGLDDTWMQALSQF 234
           +PL + A L    +  L Q 
Sbjct: 334 KPLHLEAPLPAELVAFLEQL 353


>UniRef50_A9NGF1 Pseudouridine synthase n=1 Tax=Acholeplasma laidlawii PG-8A
           RepID=A9NGF1_ACHLI
          Length = 297

 Score =  102 bits (254), Expect = 1e-20,   Method: Compositional matrix adjust.
 Identities = 72/242 (29%), Positives = 121/242 (50%), Gaps = 28/242 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVV-MQTVRDQIGQHVF------TAHRLD 54
           L I+Y+D+ ++ +NKP G +VH S    +  +V  +    D +  H          HR+D
Sbjct: 76  LNIVYEDDDIMVINKPKGLVVHPSETFSETTLVSGLLHHTDTLSTHNDDPLRPGILHRID 135

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIAD 113
           + TSG++L+  ++EA ++LAQ  + H I++ Y A+V G L   + V+D P+     KI  
Sbjct: 136 KDTSGLILVAKTNEAHKILAQDLKSHDIKREYIALVEGVLDHNKGVIDAPIARH-PKIRT 194

Query: 114 KFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
           K A    G +PA+TH+  + T              + L+  + +TGR HQ+R HLA+++H
Sbjct: 195 KMAVVATG-KPAITHFEVMRTFR-----------DHTLLHCKLETGRTHQIRVHLAYIKH 242

Query: 174 PIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           P+ GD  +G   +     +       +LHA +L   HP T + + + A L   +   L  
Sbjct: 243 PVTGDPLYGTKAKILKDGQ-------LLHAFRLEFVHPITKKVMMLEAPLPPEFESYLVT 295

Query: 234 FG 235
            G
Sbjct: 296 LG 297


>UniRef50_D0MK65 Pseudouridine synthase n=1 Tax=Rhodothermus marinus DSM 4252
           RepID=D0MK65_RHOM4
          Length = 235

 Score =  102 bits (254), Expect = 1e-20,   Method: Compositional matrix adjust.
 Identities = 78/232 (33%), Positives = 121/232 (52%), Gaps = 25/232 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRD-EKVVVMQTVRDQIGQHVFTAHRLDRPTSGV 60
           L ILY+D+ L+AV+KP G     +  +RD  +    + +    G+ ++  HRLD+  SGV
Sbjct: 3   LPILYEDDDLLAVHKPEGLA---AIPERDPSRPSARRLLEAARGERLWVVHRLDKEASGV 59

Query: 61  LLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADKFARED 119
           LL   ++EA R +   FEQ Q++K Y A+V G L   +  +  P+       + +   + 
Sbjct: 60  LLFARNAEAHRYMNTLFEQRQVRKVYRALVHGRLEPGQGQIRAPIRM---YGSGRMGVDP 116

Query: 120 KGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDS 179
           +  +P+ T YR L           Y    Y L+E  P TGR+HQ+R H  H+ HPI+GD 
Sbjct: 117 ERGKPSETRYRVLE----------YLDEAYSLIEALPLTGRRHQIRVHCYHIGHPIVGDP 166

Query: 180 KHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
           ++GD    RS  + +   RLMLHA  +   HP  G+ L I A + +++ Q L
Sbjct: 167 RYGD----RSVQQRY--PRLMLHALSIRFRHP-NGQELEIVAPVPESFQQVL 211


>UniRef50_B7GLK3 Pseudouridine synthase n=11 Tax=Bacillaceae RepID=B7GLK3_ANOFW
          Length = 292

 Score =  102 bits (253), Expect = 2e-20,   Method: Compositional matrix adjust.
 Identities = 70/238 (29%), Positives = 120/238 (50%), Gaps = 33/238 (13%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDE-------KVVVMQTVRDQIGQHVFTAHRLD 54
           L I+Y+D++++ +NKP     H S +   E         ++    + Q+   V    RLD
Sbjct: 80  LAIVYEDDYVIVINKPP----HMSTIPSREHPHGTLANALLHHYEQQQLQTTVHVVTRLD 135

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIAD 113
           R TSG++L+        LL++Q +Q ++++RY A+  G++++    +D P+  + D I +
Sbjct: 136 RDTSGLVLVAKHRHVHHLLSEQQKQGRVKRRYEAVCHGYVIQLVGTIDAPIGRKGDSIIE 195

Query: 114 KFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
           +  R D   Q AVTHY  L                   V ++ +TGR HQ+R H +H+ H
Sbjct: 196 REVRLDG--QRAVTHYEVLQQ-----------KNEMTHVSIQLETGRTHQIRVHFSHIGH 242

Query: 174 PIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
           P++GD  +G LR++        + R  LH+ +L+  HPF  + +T HA L D   + L
Sbjct: 243 PLVGDDLYGGLREH--------IDRQALHSCELTFFHPFFEKTMTFHAPLPDDIARLL 292


>UniRef50_A5IZB6 Pseudouridine synthase n=4 Tax=Mycoplasma RepID=A5IZB6_MYCAP
          Length = 305

 Score =  102 bits (253), Expect = 2e-20,   Method: Compositional matrix adjust.
 Identities = 70/231 (30%), Positives = 119/231 (51%), Gaps = 28/231 (12%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIGQ-----HVFTAHRLD 54
           L+I Y+DE+L+ +NKPSG +VH +    ++ +V  +M   ++ +        +   HR+D
Sbjct: 76  LDIRYEDEYLLILNKPSGLVVHPAPGHLNDTLVNALMYHFKNNLSDANGLLRLGIVHRID 135

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADK 114
           + TSG+L++   +E    LA+  + HQI++ Y AI  G L  +            KI   
Sbjct: 136 KDTSGLLIIAKDNETHNELAKMLKNHQIKRTYLAICEGILPNKTT----------KINLP 185

Query: 115 FAREDKGPQPAVTHYRGLATVE-MPVATGRYPTTR-YGLVELEPKTGRKHQLRRHLAHLR 172
             R+ K  +    H  G ++V  + +    Y   + Y LV+ E +TGR HQ+R HLA+++
Sbjct: 186 IQRDTKNRKLMSIHKDGKSSVTYVHMLKSFYIDNKPYSLVKCELETGRTHQIRVHLAYIK 245

Query: 173 HPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGL 223
           HP+ GDS +G         + F  QR  LHA +LS  HP   + + +++ +
Sbjct: 246 HPVYGDSIYG------KSVDEFN-QR--LHAYKLSFMHPVINKLIEVYSDI 287


>UniRef50_A9RVX3 Predicted protein n=1 Tax=Physcomitrella patens subsp. patens
           RepID=A9RVX3_PHYPA
          Length = 361

 Score =  102 bits (253), Expect = 2e-20,   Method: Compositional matrix adjust.
 Identities = 67/219 (30%), Positives = 105/219 (47%), Gaps = 28/219 (12%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHR----SWLDRDEKVVVMQTVRDQI--GQHVFTAHRLDR 55
           +E LY+D++++ V+KP   LVH     S L++     +   V  Q+  GQ V   HRLDR
Sbjct: 66  IERLYEDQYIIGVSKPGTLLVHNNKASSPLEKQRNAFLKNMVEAQLTAGQKVSPVHRLDR 125

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKF 115
           P SG ++   S+ A R            K Y  + RG   +  + D P+ +E        
Sbjct: 126 PASGAIIFSKSAVATRAAQASLSHPACIKEYVVLARGTTPDFFICDEPVNDE-------- 177

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
                 P+ AV+    +  +         P +R  L+++  KTGR HQ+R+HL H  H +
Sbjct: 178 ---KGAPKSAVSQCEKILDL---------PESRCSLLKVVIKTGRWHQIRKHLNHRAHHV 225

Query: 176 IGDSKHGDLRQNRSGAEHFGL--QRLMLHASQLSLTHPF 212
           +GD KHG  + NR   E+  +   R+ LHA++L+  HP 
Sbjct: 226 VGDVKHGKGKTNRFFRENHKMLSGRIFLHAARLTFPHPL 264


>UniRef50_P0AA37 Ribosomal large subunit pseudouridine synthase A n=205
           Tax=Proteobacteria RepID=RLUA_ECOLI
          Length = 219

 Score =  102 bits (253), Expect = 2e-20,   Method: Compositional matrix adjust.
 Identities = 80/224 (35%), Positives = 114/224 (50%), Gaps = 20/224 (8%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           L ILYQD+ ++ VNKPSG L     L+  +  V+ +  RD       + HRLD  TSGV+
Sbjct: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDY--PQAESVHRLDMATSGVI 71

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADKFAREDK 120
           ++ L+  A R L +QF + + +K+Y A V G     E ++D PL+ +      +    + 
Sbjct: 72  VVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYET 131

Query: 121 GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSK 180
           G +PA T Y     VE       Y       V L+P TGR HQLR H+  L HPI+GD  
Sbjct: 132 G-KPAQTEYE---VVE-------YAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRF 180

Query: 181 HGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLD 224
           +    + R+ A      RL+LHA  L++THP  G  +T  A  D
Sbjct: 181 YAS-PEARAMAP-----RLLLHAEMLTITHPAYGNSMTFKAPAD 218


>UniRef50_P50513 Ribosomal large subunit pseudouridine synthase D n=8
           Tax=Sphingomonadales RepID=RLUD_ZYMMO
          Length = 317

 Score =  101 bits (252), Expect = 2e-20,   Method: Compositional matrix adjust.
 Identities = 71/235 (30%), Positives = 115/235 (48%), Gaps = 33/235 (14%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV-------------VMQTVRDQIGQHVF 48
           LEI+++DE L+ VNKP+G +VH +  + D  +V             +    R  I     
Sbjct: 82  LEIVFEDEHLLVVNKPAGMVVHPAAGNYDNTLVNALLYHCAGKLSGIGGVARPGI----- 136

Query: 49  TAHRLDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLV-EE 107
             HR+D+ TSG+L++  +  A   LA QF  H I +RY AIV G    +  +D PL    
Sbjct: 137 -VHRIDKDTSGLLVVAKTDPAHAGLAAQFADHSINRRYRAIVDGHPSLQGHVDAPLARSS 195

Query: 108 LDKIADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRH 167
           +++       + +G + AVTHYR +            P     L+E   +TGR HQ+R H
Sbjct: 196 VNRQKMAIVSDGRGKR-AVTHYRMIT-----------PLKNASLIECRLETGRTHQVRVH 243

Query: 168 LAHLRHPIIGDSKHGDLRQ-NRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHA 221
           ++ + H ++GD  +G  ++ + +  +    QR  LHA+ L   HP +G+ +   A
Sbjct: 244 MSSIGHSLLGDPVYGRSKKAHHALLQSLAFQRQALHAAHLGFIHPISGKQVDFDA 298


>UniRef50_Q87AR7 Ribosomal large subunit pseudouridine synthase D n=18
           Tax=Gammaproteobacteria RepID=RLUD_XYLFT
          Length = 331

 Score =  101 bits (252), Expect = 2e-20,   Method: Compositional matrix adjust.
 Identities = 77/242 (31%), Positives = 117/242 (48%), Gaps = 22/242 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTA---HRLDRPTS 58
           L+ILY+DE +  +NKP+G +VH    + D  +V     RD     V  A   HRLD+ TS
Sbjct: 90  LDILYEDEHVFVINKPAGLVVHPGAGNPDGTLVNALLHRDPALAAVPRAGVVHRLDKDTS 149

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           GV+++  + +A   L +Q    Q+ ++Y A+V   L+    ++   +E   +   +    
Sbjct: 150 GVMVVARTLQAQTALVEQLSSRQVHRQYLAVVVSALVSGGTVNAA-IERHPRDRLRMEVS 208

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
           D G + AVTHYR            R     +  +E    TGR HQ+R H+AHLRHPI+GD
Sbjct: 209 DTGKE-AVTHYRL-----------RERFRAHTALECRLDTGRTHQIRVHMAHLRHPIVGD 256

Query: 179 SKH-GDLRQNRSGAEHF-----GLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALS 232
             + G L+  + G +       G +R  LHA  L   HP    P+ I A + +   Q L+
Sbjct: 257 RLYGGSLKLPKGGTDALVAMLRGFKRQALHAEVLEFLHPVRALPVRIVAPVPEDLCQLLA 316

Query: 233 QF 234
             
Sbjct: 317 AL 318


>UniRef50_A6NVX8 Pseudouridine synthase n=1 Tax=Bacteroides capillosus ATCC 29799
           RepID=A6NVX8_9BACE
          Length = 299

 Score =  101 bits (252), Expect = 2e-20,   Method: Compositional matrix adjust.
 Identities = 78/230 (33%), Positives = 117/230 (50%), Gaps = 24/230 (10%)

Query: 4   ILYQDEWLVAVNKPSGWLV--HRSWLDRDEKVVVMQTVRD-QIGQHVFTAHRLDRPTSGV 60
           ILYQD  L+A++KP+G L   H     R    ++  T+RD    + +F  HRLDR TSG 
Sbjct: 81  ILYQDRDLIAIDKPAGLLTVGHEGERQRTAYRLLADTLRDGSREKKLFVVHRLDRDTSGA 140

Query: 61  LLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADKFARED 119
           +L   + E  R L + ++    ++ Y A+  G    EE V+   L E   ++        
Sbjct: 141 VLFARNEEMKRALQEDWDSLVKERIYLAVTVGAPEREEGVVRSWLRETSTRVVYSGG-PG 199

Query: 120 KGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDS 179
            G + AVT Y+ LA            +  Y LV +   TGRK+Q+R H+A L  P+ GD 
Sbjct: 200 SGAKEAVTRYKVLAR-----------SGEYALVRVALDTGRKNQIRVHMADLGCPVAGDK 248

Query: 180 KHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQ 229
           K+GD     SG     + RL LHA +L++T P TG PLT+ A +  ++++
Sbjct: 249 KYGD----GSGP----MDRLALHAVRLTITDPRTGAPLTVTAPVPKSFLR 290


>UniRef50_C1ZMP6 Pseudouridine synthase n=1 Tax=Planctomyces limnophilus DSM 3776
           RepID=C1ZMP6_PLALI
          Length = 246

 Score =  101 bits (252), Expect = 2e-20,   Method: Compositional matrix adjust.
 Identities = 78/241 (32%), Positives = 117/241 (48%), Gaps = 24/241 (9%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQ----TVRDQIGQHVFT--AHRLDRPT 57
           IL++D   + V KP+G L        DE +V +      +R Q   +V+    HRLDRP 
Sbjct: 6   ILFEDNHCLVVEKPAGVLTMGDETG-DENMVQLAMDDLKIRHQKPGNVYVGLVHRLDRPV 64

Query: 58  SGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEA--VLDYPLVEELDKIADKF 115
           SGVLL+  +S+A   L+ QF + + +K Y AIV G L   A  ++D+ + ++        
Sbjct: 65  SGVLLLAKTSKAASRLSAQFREREPEKVYLAIVEGQLNPAAGEIVDWLIKDQERNHTRVT 124

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
           + +  G + A   YR L T+  P            LVE++P TGR HQ+R  LAH    I
Sbjct: 125 SPQTPGAKQAKLRYRQLETLVTPEGI-------RTLVEVQPMTGRSHQIRVQLAHAGASI 177

Query: 176 IGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFG 235
           +GD ++G            G + + LHA  L+  HP   +PLTI+A L   W   ++   
Sbjct: 178 LGDLRYGS-------KTPLG-KMIALHARSLTFEHPVQKQPLTIYAPLPSDWKPFMNPLL 229

Query: 236 W 236
           W
Sbjct: 230 W 230


>UniRef50_Q30NR3 Pseudouridine synthase n=1 Tax=Sulfurimonas denitrificans DSM 1251
           RepID=Q30NR3_SULDN
          Length = 304

 Score =  101 bits (252), Expect = 2e-20,   Method: Compositional matrix adjust.
 Identities = 67/222 (30%), Positives = 111/222 (50%), Gaps = 35/222 (15%)

Query: 6   YQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLMGL 65
           + +E  V  +KPSG L+H    +R  +  ++  ++ Q G +   AHR+D+ TSG++L   
Sbjct: 74  FIEERFVVFDKPSGMLIHPQ--NRFTEYSLIDELKAQFGMNANIAHRIDQETSGLVLCAK 131

Query: 66  SSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLV---EELDKIADKFAREDKGP 122
             ++   +   F++  ++K+Y A+V G L EE  +D PL+   +E   +     + D   
Sbjct: 132 DKKSEVDIKMMFQERDMKKKYLAMVHGELKEELRIDAPLLRYDDEKSALVRMVVKVDPTG 191

Query: 123 QPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHG 182
           + ++T  R L           +P T   LVE  P TGR+HQ+R H+ H++HPI+GD  +G
Sbjct: 192 KESLTFVRPLKY---------FPITDTTLVECSPHTGRQHQIRVHMFHMKHPIVGDPVYG 242

Query: 183 ----------------DLRQNRSGAEHFGLQRLMLHASQLSL 208
                           D R   SGA     +RL+LHA++L  
Sbjct: 243 QSEESVVRYLDRKIERDERVKLSGA-----KRLLLHANELEF 279


>UniRef50_Q0VQN9 Pseudouridine synthase n=2 Tax=Alcanivorax RepID=Q0VQN9_ALCBS
          Length = 317

 Score =  101 bits (251), Expect = 3e-20,   Method: Compositional matrix adjust.
 Identities = 75/231 (32%), Positives = 119/231 (51%), Gaps = 18/231 (7%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQH--VFTAHRLDRPTSGVL 61
            +Y+D+ L   NKP+G  VH         + +++ +R    Q   +   HRLDR TSG++
Sbjct: 97  CVYEDDQLFVFNKPAGLAVHGGS---GVSLGLIEALRVMFPQERELELVHRLDRDTSGLI 153

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKG 121
           ++       R L +  +  QI+KRY  + +G+  +E  LD PL++ ++   ++  R  + 
Sbjct: 154 MVARRRSFLRKLQRLMQGGQIEKRYWLLCQGFKGKERTLDAPLLKMMNG-NERIVRVSRE 212

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
            +P+VTH+R L          R+   +  LVE   +TGR HQ+R H       ++GDSK+
Sbjct: 213 GKPSVTHFRLLE---------RFAQAQ--LVEATLETGRTHQIRVHSQFGGFALLGDSKY 261

Query: 182 GDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALS 232
           G  +     AE  G +RL LHA  L   HP TG+ LT+ A LDD +   L+
Sbjct: 262 GIAKGEALLAE-IGRRRLCLHARTLVFVHPNTGKRLTVTAPLDDDYEAILT 311


>UniRef50_Q7MA82 Pseudouridine synthase n=1 Tax=Wolinella succinogenes
           RepID=Q7MA82_WOLSU
          Length = 308

 Score =  100 bits (250), Expect = 3e-20,   Method: Compositional matrix adjust.
 Identities = 82/250 (32%), Positives = 119/250 (47%), Gaps = 30/250 (12%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           LE L+   +    +KP+  LVH       E   +M  VR + GQ    AHR+D+ TSG++
Sbjct: 70  LEPLFIAPFFALFDKPADLLVHPK--GTFEHYSLMDEVRLRFGQEADLAHRIDKETSGIV 127

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKF-AREDK 120
           L+  S + G +L   F   +++K Y A+VRG +  E +LD+PL  +  ++      R D+
Sbjct: 128 LITRSKKEGAILKINFFNREVKKCYWALVRGKMEGERILDFPLKAQSKRLDLGVRMRVDE 187

Query: 121 GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSK 180
             + ++T  + L    +   T         LVE  P TGR HQ+R HLAH  +PI+GD  
Sbjct: 188 KGKSSLTQIKALDYEALSDTT---------LVEASPLTGRTHQIRLHLAHAGYPILGDPL 238

Query: 181 HGD--------LRQNRSGAEH---FGLQRLMLHASQLSLTHPFTGEPLTIHAGLD----- 224
           +G         L Q     E    FG  RLMLHA  L    P+ G    I +G D     
Sbjct: 239 YGTSDELSRAYLEQAMDQEERRRCFGASRLMLHAQGLGF--PYKGSWYEIVSGQDFLGEV 296

Query: 225 DTWMQALSQF 234
           +   +AL QF
Sbjct: 297 EGAREALRQF 306


>UniRef50_UPI0001C36F41 hypothetical protein RflaF_04377 n=1 Tax=Ruminococcus flavefaciens
           FD-1 RepID=UPI0001C36F41
          Length = 446

 Score =  100 bits (250), Expect = 3e-20,   Method: Compositional matrix adjust.
 Identities = 72/222 (32%), Positives = 108/222 (48%), Gaps = 29/222 (13%)

Query: 5   LYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTA-HRLDRPTSGVLLM 63
           +Y+ + ++  NKPSG  VH S   + +   +            F A +RLDR TSG+ ++
Sbjct: 81  VYESDGVIVFNKPSGMPVHPSI--KHQGDTLGNKFAAMFPDLTFRAVNRLDRDTSGLCVV 138

Query: 64  GLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKGPQ 123
             ++ A         Q + +K Y+A V G + E   +D P+  E + I  +  RED   Q
Sbjct: 139 AKNALA-----ANALQGRCEKVYYAAVTGEIPETGTIDAPIARERESIIIRCVREDG--Q 191

Query: 124 PAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHGD 183
            AVTHYR +A              RY L E+  +TGR HQ+R H +++ HP+ GD  +G 
Sbjct: 192 RAVTHYRRIAY-----------NGRYSLAEIHLETGRTHQIRVHFSYIGHPLAGDDLYGG 240

Query: 184 LRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDD 225
            R +        + R  LH  Q+S T P TGE +T+ A L D
Sbjct: 241 TRCD--------IGRQALHCGQMSFTDPVTGEEVTVRAELPD 274


>UniRef50_B2S2H8 Pseudouridine synthase n=2 Tax=Treponema pallidum
           RepID=B2S2H8_TREPS
          Length = 216

 Score =  100 bits (250), Expect = 4e-20,   Method: Compositional matrix adjust.
 Identities = 77/231 (33%), Positives = 114/231 (49%), Gaps = 23/231 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           L I++QD  +VAV+KP+G  V      R   V V+  ++ Q+G  +F  HRLD+ T+GVL
Sbjct: 3   LPIIFQDAAVVAVDKPAGLAVQPGARVR---VCVVDVLQKQLGVRLFPLHRLDKDTAGVL 59

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAV-LDYPLVEELDKIADKFAREDK 120
           L    + A  L        ++ KRY A+  G    E   +  P+           AR  +
Sbjct: 60  LFAKHARAAALYQGILGSMRVIKRYRALCFGRPPRECGDIRVPIRT------GTAARRRQ 113

Query: 121 GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSK 180
             + A T YR L             T  +  +EL   +GR HQ+R HLA L  PIIGD K
Sbjct: 114 VVRAAHTAYRVLRA-----------TDTHTYLELTLHSGRTHQIRIHLAALGCPIIGDDK 162

Query: 181 HGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
           +GD  +N++ A  +G++RL L A  L L  P   +PL + A +   +++AL
Sbjct: 163 YGDFARNKACARAWGVKRLQLFAHSLVL--PCACKPLVLRARMPVHFLRAL 211


>UniRef50_Q1MQ60 Pseudouridylate synthases, 23S RNA-specific n=1 Tax=Lawsonia
           intracellularis PHE/MN1-00 RepID=Q1MQ60_LAWIP
          Length = 541

 Score =  100 bits (250), Expect = 4e-20,   Method: Compositional matrix adjust.
 Identities = 73/224 (32%), Positives = 109/224 (48%), Gaps = 20/224 (8%)

Query: 1   MLEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV-----VMQTVRDQIGQHVFTAHRLDR 55
            LEIL+ DE L  +NKP G  VH +   ++  +V         + +Q G      HR+D+
Sbjct: 82  FLEILFSDEHLAIINKPPGLTVHPAPSCQESTLVHRLLKYFPKLIEQGGLRPGIVHRIDK 141

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKF 115
            TSG+L + L+ +    L++ F   +I K Y A+V G    E  +  PL  +  K   K 
Sbjct: 142 DTSGLLCIALTEDTRLKLSKIFLDRKINKEYLALVHGVPSMEGYIAVPLGRD-PKTKVKV 200

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
           A   KG +PA T +R L          R     Y ++ L  +TGR HQ+R H+ H+ HP+
Sbjct: 201 AVNPKG-KPAHTEWRVLH---------RGKNDVYSILALTIQTGRTHQIRVHMKHIGHPL 250

Query: 176 IGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTI 219
           +GD  +     N++    F   R MLHA +LS  HP TG+ +  
Sbjct: 251 VGDKLYAGGHVNKT----FQCNRQMLHAWKLSFEHPITGKKMNF 290


>UniRef50_C7NAV5 Pseudouridine synthase n=5 Tax=Fusobacteriaceae RepID=C7NAV5_LEPBD
          Length = 326

 Score =  100 bits (250), Expect = 4e-20,   Method: Compositional matrix adjust.
 Identities = 73/243 (30%), Positives = 124/243 (51%), Gaps = 28/243 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIGQH----VFTAHRLDR 55
           +EI+Y+D  L  +NK +G +VH +       +V  ++  ++D  G +        HRLD+
Sbjct: 99  IEIIYEDNDLAVINKKAGIVVHPANGHYSGTLVNAILYHIKDLSGINGEIRPGIVHRLDK 158

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKF 115
            TSG+L++  + +A   L+Q F    ++K Y AI++G L +++           +I  + 
Sbjct: 159 DTSGLLIIAKNDKAHLKLSQMFHDKTVKKIYLAILKGKLNQKS----------GRIVTQI 208

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRY--PTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
            R DK  +  +T    L + +  +        T ++ LV++  +TGR HQ+R H+ HL +
Sbjct: 209 GR-DKNDRKKMTVINDLNSGKTAITNYEVISQTEKFTLVKVHIETGRTHQIRVHMKHLGY 267

Query: 174 PIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           PI+GDS +G     R+  E    +R MLHA +L   HP T E L   A L + + +AL +
Sbjct: 268 PILGDSVYG-----RTDTE----KRQMLHAYKLEFQHPITEENLEFIAKLPEDFKKALKK 318

Query: 234 FGW 236
            G 
Sbjct: 319 CGL 321


>UniRef50_A6Q113 Pseudouridine synthase n=1 Tax=Nitratiruptor sp. SB155-2
           RepID=A6Q113_NITSB
          Length = 299

 Score =  100 bits (249), Expect = 5e-20,   Method: Compositional matrix adjust.
 Identities = 71/222 (31%), Positives = 110/222 (49%), Gaps = 27/222 (12%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           L+ +++ +  V  +KPSG +VH    +R+    ++  +R + G      HR+D+ TSG++
Sbjct: 70  LKPIFETKDFVLYDKPSGIMVHPR--NRNTHYTLIDEIRYRYGPQANIVHRIDKETSGLV 127

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELD--KIADKFARED 119
           L   + EA + L Q FE  QIQKRY A+VRG + ++ V++ P+    D  KI  K   + 
Sbjct: 128 LASTNKEAEKALKQMFEHKQIQKRYLALVRGNIEKQLVIEEPIALNRDYSKIKLKVKIDP 187

Query: 120 KGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDS 179
            G        +   T+  P+         + LVE  P TGR+HQ+R HL H++HPI+GD 
Sbjct: 188 SG--------KYAKTIINPLKQ----FGSFTLVEAIPITGRQHQIRIHLFHVKHPILGDP 235

Query: 180 KHGD-----------LRQNRSGAEHFGLQRLMLHASQLSLTH 210
            +G            L          G  RLMLHA  +  T+
Sbjct: 236 IYGPSTNESIRYLDGLMDEEERLVVTGATRLMLHAYAVEFTY 277


>UniRef50_A6LIG6 Pseudouridine synthase n=5 Tax=Bacteroidales RepID=A6LIG6_PARD8
          Length = 304

 Score =  100 bits (249), Expect = 5e-20,   Method: Compositional matrix adjust.
 Identities = 70/223 (31%), Positives = 113/223 (50%), Gaps = 29/223 (13%)

Query: 1   MLEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ-----HVFTAHRLDR 55
           +L I+++D+ L+ +NK  G L   +  DR ++    + + D + +      +F  HRLDR
Sbjct: 90  LLRIVWEDDDLIVINKREGLLSVST--DRIKERTAYRILSDYLKECDPRNKIFVLHRLDR 147

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEA-VLDYPLVEELDKIADK 114
            TSG+++   + +    L   + +   Q+ Y A++ G   ++  ++   LVE  +K    
Sbjct: 148 DTSGIMMFAKNQKVKEQLQSNWSEAITQRTYVAVIEGRPEKDTDLIVSNLVE--NKHMQV 205

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
           +  +D   + A+T YR L T             RY LVEL+ +TGRK+Q+R  +  + HP
Sbjct: 206 YVTQDGDGKEAITRYRLLQT-----------NNRYSLVELDLETGRKNQIRAQMQSIGHP 254

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPL 217
           I GDSK+        GAE     RLMLHA +L   HP TGE +
Sbjct: 255 IAGDSKY--------GAETNPAGRLMLHARRLCFIHPVTGEEM 289


>UniRef50_Q3YSF8 Pseudouridine synthase n=5 Tax=canis group RepID=Q3YSF8_EHRCJ
          Length = 308

 Score =  100 bits (249), Expect = 5e-20,   Method: Compositional matrix adjust.
 Identities = 62/206 (30%), Positives = 108/206 (52%), Gaps = 19/206 (9%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLM 63
           ILY+D+ ++ +NKP+G  V      R     ++  +RD  G+ +   HRLD+ TSG+L++
Sbjct: 93  ILYEDDDVLIINKPAGVSVQGGTKVRISISDILDKIRD--GESMRIVHRLDKDTSGILML 150

Query: 64  GLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEA-VLDYPLVEELDKIADKFAREDKGP 122
             ++ A RL+  +F+  +++K+Y A+ +G    +   +++ + ++     +     +   
Sbjct: 151 ARNARASRLIMHEFKNRRVEKKYLALTQGIPKNDVGEINHSITKKKHNFYENIGTGNSIF 210

Query: 123 QPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHG 182
           Q A+T +  L  +   +          GL+EL+PKTGRKHQ+R HL+H+   IIGD K+G
Sbjct: 211 QEAITSFFVLKKLPYDI----------GLLELKPKTGRKHQIRIHLSHIGCSIIGDKKYG 260

Query: 183 DLRQNRSGAEHFGLQRLMLHASQLSL 208
                     H     L LHA  LS+
Sbjct: 261 KF------CNHVLNDHLQLHAHFLSI 280


>UniRef50_Q3ABZ7 Pseudouridine synthase n=2 Tax=Bacteria RepID=Q3ABZ7_CARHZ
          Length = 305

 Score =  100 bits (249), Expect = 5e-20,   Method: Compositional matrix adjust.
 Identities = 79/240 (32%), Positives = 126/240 (52%), Gaps = 25/240 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQ----IGQHV--FTAHRLDR 55
           L+I+Y+DE LV VNK +G +VH +  + D  +V       Q    IG  +     HRLD+
Sbjct: 82  LDIVYEDEDLVVVNKKAGMVVHPAEGNWDGTLVNALLYHCQNLSGIGGVLRPGIVHRLDK 141

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADK 114
            TSG+L++  +  A + LA+Q ++ +  + Y  IV G+L  +E ++D P+     +   K
Sbjct: 142 DTSGLLVVAKNDLAHQSLAEQIKEKKAVREYWTIVHGYLKNKEGIIDLPIGRH-PRDRQK 200

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
            A    G + A T Y+ L                + L++ +  TGR HQ+R H ++L HP
Sbjct: 201 MAVVSNG-KTAQTVYKVLEEF----------NKGFTLIQAKLLTGRTHQIRVHFSYLGHP 249

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           ++GD K+G   QN      FG++R MLHA +LS  HP +GE L   A L + + + L++ 
Sbjct: 250 VLGDPKYG--HQNNP----FGVKRQMLHAIKLSFIHPRSGELLEFTAPLPEDFQRVLAKL 303


>UniRef50_B6BGX6 Pseudouridine synthase n=1 Tax=Campylobacterales bacterium GD 1
           RepID=B6BGX6_9PROT
          Length = 308

 Score =  100 bits (249), Expect = 5e-20,   Method: Compositional matrix adjust.
 Identities = 67/217 (30%), Positives = 108/217 (49%), Gaps = 31/217 (14%)

Query: 8   DEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLMGLSS 67
           DE++V  +KPSG L+H    +R     ++  ++ Q G+    AHR+D+ TSG++L   + 
Sbjct: 77  DEFVV-FDKPSGVLIHPQ--NRKTPYSLIDELKYQYGRDANIAHRIDQETSGLVLCAKNK 133

Query: 68  EAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELD-----KIADKFAREDKGP 122
           E+ R +   FEQ  ++K+Y A+V G L E   ++ PL+   D     ++  K   E K  
Sbjct: 134 ESERDIKMMFEQRDMKKKYLALVHGELKESICIEEPLLRREDESAIVRMVVKVHEEGKAS 193

Query: 123 QPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHG 182
           +  +   +  A  +M             LVE  P TGR+HQ+R HL H++HPI+GD  +G
Sbjct: 194 KTDIRPLKYFAETDM------------TLVECSPYTGRQHQIRVHLFHVKHPIVGDPIYG 241

Query: 183 DLRQN-----------RSGAEHFGLQRLMLHASQLSL 208
              ++               E  G  RL+LHA++L  
Sbjct: 242 QSEEDIVKFLDKELDAEKRIELSGASRLLLHANELEF 278


>UniRef50_B0VJ94 Pseudouridine synthase n=1 Tax=Candidatus Cloacamonas
           acidaminovorans RepID=B0VJ94_9BACT
          Length = 351

 Score =  100 bits (248), Expect = 7e-20,   Method: Compositional matrix adjust.
 Identities = 73/262 (27%), Positives = 123/262 (46%), Gaps = 56/262 (21%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFT---------AHR 52
           L+++Y+DE+L  +NK +G +VH  + + +  +V    +  + G+++ +          HR
Sbjct: 89  LDVVYEDEYLAIINKKAGMIVHPGFGNPEGTLV--NAILYRFGENLSSGKEFNRPGIVHR 146

Query: 53  LDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDK-- 110
           LDR TSG++++  +      L+  F + +I+K Y AI  G            + E +K  
Sbjct: 147 LDRGTSGLIIIAKNDLTHAKLSDMFARREIKKTYFAITTG------------IPEPEKGE 194

Query: 111 IADKFAREDKGPQP---------AVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRK 161
           I    AR +K P+          A+THY+ + T              + LVE+ P TGR 
Sbjct: 195 IETYLARSNKNPRTICVTNEGRYALTHYKTIKTWHY-----------FALVEINPATGRM 243

Query: 162 HQLRRHLAHLRHPIIGDSKHGDLRQNRSGAEHFG-----------LQRLMLHASQLSLTH 210
           HQ+R H AH+R+PI+GD  +   R  +S                 L+R  LH+ +L   H
Sbjct: 244 HQIRVHFAHIRYPILGDLLYNSRRYVQSLVPQNMKKKVTELLVNHLRRQALHSWKLEFFH 303

Query: 211 PFTGEPLTIHAGLDDTWMQALS 232
           P TG P+++ A + D     L+
Sbjct: 304 PITGYPISVSAPIPDDIQYTLN 325


>UniRef50_UPI00016C40E0 pseudouridine synthase n=1 Tax=Gemmata obscuriglobus UQM 2246
           RepID=UPI00016C40E0
          Length = 238

 Score =  100 bits (248), Expect = 7e-20,   Method: Compositional matrix adjust.
 Identities = 77/235 (32%), Positives = 111/235 (47%), Gaps = 23/235 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSW----LDRDEKVVVMQTVRDQIGQHVFTAHRLDRPT 57
           L +LY+D  LV VNKP+  L         L+   +  +        G ++   HRLDRP 
Sbjct: 9   LAVLYEDHHLVVVNKPAPLLTQAPPGVPNLEERVRAYIKDKYAKPAGVYLGVPHRLDRPV 68

Query: 58  SGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAR 117
           SGV+    +++A + +  QFE   ++K Y A+V G           +VE    + D + R
Sbjct: 69  SGVVCFARNTKAAQRVHSQFEHRSVRKVYWALVEG-----------VVEPDAGVWDDYIR 117

Query: 118 EDKGPQPAVTHYRG-----LATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLR 172
           + +    A   + G     LAT+E  V       TR   +EL P TGR HQLR   A   
Sbjct: 118 KVENEARAARGHEGEPGAKLATLEFRVLERFAAHTR---IELHPLTGRMHQLRVQSAWRG 174

Query: 173 HPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTW 227
           HP+IGDS +G +R     AE    + + LHA +L+  HPFT + L I A +   W
Sbjct: 175 HPVIGDSLYGSVRPFGPPAELPRDRVIALHARRLTFEHPFTKQELVIEAPVPAYW 229


>UniRef50_D1AV01 Pseudouridine synthase n=2 Tax=Bacteria RepID=D1AV01_STRM9
          Length = 297

 Score = 99.8 bits (247), Expect = 8e-20,   Method: Compositional matrix adjust.
 Identities = 67/239 (28%), Positives = 125/239 (52%), Gaps = 27/239 (11%)

Query: 5   LYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIGQH----VFTAHRLDRPTS 58
           +Y+D++L  +NK +G +VH S    ++ +V  +M  ++D  G +        HRLD+ TS
Sbjct: 78  VYEDKYLAIINKYAGMVVHPSKGHEEDTLVNAIMYKIKDLSGINGDLRPGIVHRLDKNTS 137

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           G++++    +    L++ F+  +I+K Y+AIV+G + +++     ++        K A  
Sbjct: 138 GLIIIAKDDKTHFKLSEMFKNKEIKKIYYAIVKGKVNKKSGRIETMIGRNPNDRKKMAVV 197

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
           D G + A+T++  + + E           ++ L++++ +TGR HQ+R HL+H   PI+GD
Sbjct: 198 DNG-KLAITNFEVIDSNE-----------KFSLLKVDLETGRTHQIRVHLSHFFFPILGD 245

Query: 179 SKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWR 237
           S +G  R++          R MLHA  L+  HP T E + +       +++ALS    R
Sbjct: 246 SVYG--RKDE-------YDRQMLHAYMLNFIHPITLEKIDVIGNFHSDFLRALSNTKLR 295


>UniRef50_D0L1K7 Pseudouridine synthase n=1 Tax=Halothiobacillus neapolitanus c2
           RepID=D0L1K7_HALNC
          Length = 346

 Score = 99.8 bits (247), Expect = 8e-20,   Method: Compositional matrix adjust.
 Identities = 80/248 (32%), Positives = 123/248 (49%), Gaps = 21/248 (8%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLM 63
           I+Y+DE L+AVNKP+G  VH    +    ++ +      +G+ +  AHR+DR TSG+L++
Sbjct: 111 IVYEDEALLAVNKPAGLAVH-GGSNIPFGLIELMRQHTGLGEKLELAHRIDRDTSGLLIL 169

Query: 64  GLSSEAGRLLAQQFE-QHQIQKRYHAIVRG-WLMEEAVLDYPLVEELDKIADKFAREDKG 121
             +      L  QF  +   +K+Y AIV G W  +   +D PL +   +      + +  
Sbjct: 170 AKTRATLHSLQTQFRPEGHAEKQYLAIVHGHWPDKLKRVDAPLEKWQGEGESHRVQVNPQ 229

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
            + AVTH+  LA                 L+  + +TGR HQ+R H AH  HPI+GD K+
Sbjct: 230 GKEAVTHFAVLAA-----------NKNATLLRAQLETGRTHQIRVHTAHENHPIVGDEKY 278

Query: 182 GDLRQNR-----SGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGW 236
           G    ++     +GA       L+LHA +L LTHP T +PL + A + D W     Q   
Sbjct: 279 GQREWDKRLFPSTGASARRRPPLLLHAYRLMLTHPQTEQPLQLTAPIPDKWRSLAQQLNL 338

Query: 237 RGLLPENE 244
              LPE++
Sbjct: 339 --TLPEHD 344


>UniRef50_B1Y046 Pseudouridine synthase n=43 Tax=Proteobacteria RepID=B1Y046_LEPCP
          Length = 256

 Score = 99.8 bits (247), Expect = 8e-20,   Method: Compositional matrix adjust.
 Identities = 76/216 (35%), Positives = 107/216 (49%), Gaps = 15/216 (6%)

Query: 1   MLEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQ-IGQHVFTAHRLDRPTSG 59
           +++IL+ D+ L+ V KP+G L   S   R E +      R Q I       HRLD  TSG
Sbjct: 43  LIDILHHDDSLLVVRKPAGLL---SVPGRGEHLQDCVAARVQAIWPDALIVHRLDMATSG 99

Query: 60  VLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEA-VLDYPLVEELDKIADKFARE 118
           +++M     A R L   FE   + K+Y A+V G +  +A  +D PL  +      +    
Sbjct: 100 LMVMARGPAAQRALGSAFEHRSVTKQYVAVVAGDVAGDAGSVDLPLCADWPNRPRQKVDA 159

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
             G +P++TH+R          TG    TR   +ELEP TGR HQLR HL  L HPI+GD
Sbjct: 160 AMG-RPSLTHWRRATPAHEGSTTGDIDRTR---LELEPVTGRSHQLRVHLLALGHPILGD 215

Query: 179 SKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTG 214
           + +      R         RL+LHAS+++L HP  G
Sbjct: 216 TLYAPDAVQRMA------PRLLLHASRIALPHPAGG 245


>UniRef50_B8FT16 Pseudouridine synthase n=70 Tax=Bacteria RepID=B8FT16_DESHD
          Length = 334

 Score = 99.8 bits (247), Expect = 9e-20,   Method: Compositional matrix adjust.
 Identities = 78/241 (32%), Positives = 124/241 (51%), Gaps = 27/241 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIGQHVF----TAHRLDR 55
           LEILY+DE ++ VNK  G +VH +     + +V  ++   R+  G +        HR+D+
Sbjct: 107 LEILYEDEDVLVVNKSQGMVVHPAPGAWTKTLVNALLYHCRNLSGINGVLRPGIVHRIDK 166

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEE-LDKIAD 113
            TSG+L++  +  A + LA+Q + H + +RY AIV G + E    ++ P+  +  D+   
Sbjct: 167 DTSGLLVVAKNDLAHQGLAEQIKAHSMARRYLAIVHGVVFEPSGTVEAPIGRDPADR--K 224

Query: 114 KFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
           K A   +  + AVTHY  L                + L+E   +TGR HQ+R H+A+L+H
Sbjct: 225 KMAVVFQNAKEAVTHYEVLERFR-----------DFTLLEARLETGRTHQIRVHMAYLKH 273

Query: 174 PIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           P++GD  +G  R+N      FGLQ  MLHA  L   HP +GE +   A     + + L +
Sbjct: 274 PVLGDPLYGP-RKNP-----FGLQGQMLHAQLLGFQHPRSGEYMEFSAPASGMFQKVLEE 327

Query: 234 F 234
            
Sbjct: 328 I 328


>UniRef50_B1I3F8 Pseudouridine synthase n=2 Tax=Bacteria RepID=B1I3F8_DESAP
          Length = 309

 Score = 99.8 bits (247), Expect = 9e-20,   Method: Compositional matrix adjust.
 Identities = 76/244 (31%), Positives = 114/244 (46%), Gaps = 25/244 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIGQHVF----TAHRLDR 55
           LE+ ++D  ++ VNKP G +VH +       +V  ++   RD  G +        HRLDR
Sbjct: 81  LEVCFEDPDVLVVNKPRGLVVHPAVGHYSGTLVNALLHHCRDLSGINGILRPGIVHRLDR 140

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADK 114
            TSG+L++  +  A   LA Q +   + +RY A+V G    E   +D P+     +   +
Sbjct: 141 DTSGLLMVAKNDAAHLALAGQLKDRAVLRRYTALVHGRPRRETGTVDAPIGRH-PRDRQR 199

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
            A   +  + A THYR +   +           ++ L+EL   TGR HQ+R H+AH+ HP
Sbjct: 200 MAVTPRSGRAARTHYRVVRRFD-----------KFSLLELTLDTGRTHQIRVHMAHVGHP 248

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           ++GD K+G  R         GL+   LHA  L   HP TGE L   A L       L + 
Sbjct: 249 LVGDLKYGHARPE------LGLEGQFLHAGTLGFRHPRTGEVLVFEAPLPSELAAVLERL 302

Query: 235 GWRG 238
              G
Sbjct: 303 SPLG 306


>UniRef50_Q0A8Q9 Pseudouridine synthase n=4 Tax=Ectothiorhodospiraceae
           RepID=Q0A8Q9_ALHEH
          Length = 327

 Score = 99.8 bits (247), Expect = 9e-20,   Method: Compositional matrix adjust.
 Identities = 81/234 (34%), Positives = 114/234 (48%), Gaps = 20/234 (8%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLM 63
           ILY+D+ L+ ++KPSG  VH         + V++  R      +   HRLDR TSG L++
Sbjct: 100 ILYEDDRLLVIDKPSGLAVHGGSGLAWGLIEVLRQARPS-APFLELVHRLDRATSGCLMV 158

Query: 64  GLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKGPQ 123
                A R L +Q     + KRY A++ G L    +   P+   L++          GP 
Sbjct: 159 AKRRSALRELHEQLRTGAVHKRYLALLTGALGRGPI---PVEAPLER--------RSGPA 207

Query: 124 PAV---THYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSK 180
             V   +H +   TV   VA     T    L E +  TGR HQ+R H AHL  PI GD +
Sbjct: 208 GGVRVASHGKLARTVFRAVARPGGMT----LAEADIATGRTHQIRVHAAHLGMPIAGDDR 263

Query: 181 HGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           +G+   NR      GL+RL LHA +L L+ P TG+PL+I A L D     ++Q 
Sbjct: 264 YGERAVNRR-LRGLGLKRLFLHAHRLELSAPGTGQPLSIEAPLPDELAAVVAQL 316


>UniRef50_Q45826 Uncharacterized RNA pseudouridine synthase Caur_0901 n=5
           Tax=Chloroflexi (class) RepID=Y901_CHLAA
          Length = 316

 Score = 99.4 bits (246), Expect = 1e-19,   Method: Compositional matrix adjust.
 Identities = 75/225 (33%), Positives = 113/225 (50%), Gaps = 38/225 (16%)

Query: 2   LEILYQDEWLVAVNKPSGWLVH-----------RSWLDRDEKVVVMQTVRDQIGQHVFTA 50
           L+++Y+D  +  +NKP+G +VH            + L R   + +   +R  I       
Sbjct: 91  LDVVYEDADIAVINKPAGMVVHPAPGHPRGTLVNALLARYPDLAIGGELRPGI------V 144

Query: 51  HRLDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPL-VEELD 109
           HRLDR TSG+L++    +A R L  Q +  +++K Y A+V G   E   +D P+  +  D
Sbjct: 145 HRLDRDTSGLLVIARHDQAMRSLVDQQQARRMRKIYQALVIGRPPETGTIDAPIGRDPRD 204

Query: 110 KIADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLA 169
           ++  + A    G +PA THYR L T              Y L+E++ +TGR HQ+R HL 
Sbjct: 205 RL--RMAVVPDG-RPARTHYRLLDTF-----------GDYSLLEVQLETGRTHQIRVHLR 250

Query: 170 HLRHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTG 214
           HL +PI+GD  +G  R       H  L R  LHA+ L L HP +G
Sbjct: 251 HLGYPIVGDPVYGPRR------SHLHLSRQFLHAAYLGLVHPRSG 289


>UniRef50_A9BFW4 Pseudouridine synthase n=8 Tax=Thermotogaceae RepID=A9BFW4_PETMO
          Length = 319

 Score = 99.4 bits (246), Expect = 1e-19,   Method: Compositional matrix adjust.
 Identities = 79/248 (31%), Positives = 121/248 (48%), Gaps = 42/248 (16%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRD-----QIGQHVFTAHRLD 54
           L ILY+DE L+ +NKP+G +VH +   +   +V  +M  V+D     Q    +   HRLD
Sbjct: 85  LNILYEDEELIVINKPAGLIVHPTPSIKTGTLVNALMHHVKDLDKTMQDPNRLGIVHRLD 144

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIAD 113
           + TSGVL++  ++ +  LL+++F++ +  K Y AIV G L E E  ++ PL         
Sbjct: 145 KETSGVLVVAKNAFSHHLLSKEFKERKTMKYYLAIVEGTLKEKEGEINLPL--------- 195

Query: 114 KFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYG----------LVELEPKTGRKHQ 163
                  G  P + H R +      V  G+   T Y           LV +  +TGR HQ
Sbjct: 196 -------GRHPILRHKRAV------VYNGKEAITEYKTLKEFGDLATLVWIRLRTGRTHQ 242

Query: 164 LRRHLAHLRHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGL 223
           +R H  ++ +P+IGDS +G  +  ++     G  R MLHA +L   HP T E +   A L
Sbjct: 243 IRVHFKYIGNPLIGDSLYGKNKIEKNLQIPVG--RQMLHALKLGFYHPKTKEWMEFLAPL 300

Query: 224 DDTWMQAL 231
            D +   L
Sbjct: 301 PDDFKNLL 308


>UniRef50_C4V3I7 Pseudouridine synthase n=1 Tax=Selenomonas flueggei ATCC 43531
           RepID=C4V3I7_9FIRM
          Length = 294

 Score = 99.0 bits (245), Expect = 1e-19,   Method: Compositional matrix adjust.
 Identities = 75/228 (32%), Positives = 114/228 (50%), Gaps = 32/228 (14%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRD---QIGQHV--FTAHRLDRP 56
           L I+Y+D+ L+ ++KP+G LVH +   ++    +   VR      G H+     HRLDR 
Sbjct: 77  LSIIYEDDDLLVLDKPAGQLVHPT--TKETHGTIANAVRGYYAACGVHLDFHPCHRLDRN 134

Query: 57  TSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADKF 115
           TSG+LL+    E    +AQQ   + +++ Y A++ G L   E  +D P+   L  I  + 
Sbjct: 135 TSGLLLIAKHPEVQYQIAQQ---NTLRREYLALIAGSLTPPEGCIDVPIARALPSIILRC 191

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
              +   + A THY  + T             RY L+ L+  TGR HQ+R HLAHL HP+
Sbjct: 192 VSTEG--KSACTHYVTVQT-----------DGRYSLLRLQLDTGRTHQIRVHLAHLGHPL 238

Query: 176 IGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGL 223
           +GD  +G  R          + R  LH++ L+L HP T + L + A L
Sbjct: 239 LGDDLYGGTRAE--------IARHALHSAHLTLVHPRTKKMLALSALL 278


>UniRef50_B1ZRU1 Pseudouridine synthase n=2 Tax=Opitutaceae RepID=B1ZRU1_OPITP
          Length = 268

 Score = 99.0 bits (245), Expect = 1e-19,   Method: Compositional matrix adjust.
 Identities = 80/258 (31%), Positives = 121/258 (46%), Gaps = 41/258 (15%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLM 63
           IL++D+ ++A +KPSG L+     D+ ++  +M  V  + G  V   HRLD  TSG+LL 
Sbjct: 6   ILFEDDAMIAFDKPSGLLIAPDRWDK-QRENLMGLVHARFGHGVANVHRLDADTSGLLLC 64

Query: 64  GLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAV-LDYPLVEELDKIADKF------- 115
             +  A   L+ QF+   +QK Y ++V     EEA+ +  P+ ++   + D F       
Sbjct: 65  AKTKPALDFLSGQFQAKTVQKTYLSLVVVLPPEEAMKVVKPIRDDAGGLPDAFQVDLALG 124

Query: 116 ----------AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLR 165
                       + +G +  VT +R L               R+ LV   P+TGR HQ+R
Sbjct: 125 QDERQPGRMRVFKGRGGKDCVTDFRVLERF-----------GRFALVSCHPQTGRTHQIR 173

Query: 166 RHLAHLRHPIIGDSKHG---------DLRQNRSG--AEHFGLQRLMLHASQLSLTHPFTG 214
            HLA    PI+ D  +G         DL++   G   E   + RL LHAS+L+  HP T 
Sbjct: 174 VHLAAAGAPILNDPFYGNPEIKLLLSDLKRRYKGRDEEKPLIDRLALHASELTFRHPATR 233

Query: 215 EPLTIHAGLDDTWMQALS 232
           E LT+ A L   +  AL 
Sbjct: 234 ELLTLQAPLPHEFEIALK 251


>UniRef50_A6GAA8 Pseudouridine synthase, RluA family protein n=1 Tax=Plesiocystis
           pacifica SIR-1 RepID=A6GAA8_9DELT
          Length = 311

 Score = 98.6 bits (244), Expect = 2e-19,   Method: Compositional matrix adjust.
 Identities = 69/232 (29%), Positives = 115/232 (49%), Gaps = 15/232 (6%)

Query: 2   LEILYQDEWLVAVNKPSGW---LVHRSWLDRDEKVVVMQTVRDQIGQ-HVFTAHRLDRPT 57
           +  +++ E  V ++KP+G     V  + +    + ++ Q   + + + +V   HRLD+  
Sbjct: 85  VRFVHRGEDFVVLDKPAGVPVSAVRETCVGSLSEALIHQLESEGLERPYVGVVHRLDQGA 144

Query: 58  SGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAR 117
           SG++L  +   A + L +QF  H+I++ Y   V G    +   D PL++         + 
Sbjct: 145 SGLVLFTIRDVANKSLHKQFRDHEIRRGYRVRVTGEPPAQLRCDAPLIKLRSGGVKVGSP 204

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
            D   +PA TH+R +A V+              L+++E +TGR HQ+R H AHL  PI+G
Sbjct: 205 GDGRSKPATTHFRHVARVDGEAGPEH-------LLDVEIETGRTHQIRAHAAHLGFPIVG 257

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQ 229
           D ++G   +  +G++H    RL LHA  L   HP TG P +    L D W Q
Sbjct: 258 DRRYGADGEGEAGSDH---SRLCLHARSLEFEHPLTGAPQSFTCELPD-WAQ 305


>UniRef50_B8CWB7 Pseudouridine synthase n=1 Tax=Halothermothrix orenii H 168
           RepID=B8CWB7_HALOH
          Length = 310

 Score = 98.6 bits (244), Expect = 2e-19,   Method: Compositional matrix adjust.
 Identities = 67/227 (29%), Positives = 120/227 (52%), Gaps = 26/227 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIGQH--VFTAHRLDRPT 57
           L+I+Y+D  L+ +NKP+  LVH + +++   +V  V+  +R+Q G +  V   HRLDR T
Sbjct: 93  LDIIYEDRHLLVINKPANMLVHPTPVEKSNTIVNGVLYHMRNQ-GNYNLVRPIHRLDRNT 151

Query: 58  SGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADKFA 116
           +G+LL+  +  A   +  QF+ + I + Y A V G +  ++  ++ P+ +  D +  +  
Sbjct: 152 TGLLLIAKNQYAHNYITHQFQNNNIHREYLAFVHGNVEFKKESINAPIGKTRDSLIKRKV 211

Query: 117 REDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPII 176
               G + AVTH + +            P     L+ ++ +TGR HQ+R HL+HL HP++
Sbjct: 212 DHTLGKR-AVTHIKVVK-----------PGGLISLIRVKLETGRTHQIRVHLSHLGHPLL 259

Query: 177 GDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGL 223
           GD+ +        G E   ++R  LH+ +++   PF  + +T  A L
Sbjct: 260 GDTLY--------GGEDILIKRPALHSYKVTCCLPFKHKEVTFKAPL 298


>UniRef50_Q83G23 Pseudouridine synthase n=2 Tax=Tropheryma whipplei
           RepID=Q83G23_TROWT
          Length = 303

 Score = 98.6 bits (244), Expect = 2e-19,   Method: Compositional matrix adjust.
 Identities = 74/222 (33%), Positives = 114/222 (51%), Gaps = 28/222 (12%)

Query: 1   MLEILYQDEWLVAVNKPSGWLVHRS--WLDRD-----EKVVVMQTVRDQIGQHVFTAHRL 53
           +L ++Y D+ L  ++KP+G   H S  W           ++     +D+ G      HRL
Sbjct: 75  LLRVIYSDDDLFVIDKPAGVAAHASPGWCGPTVTGCLSGLLAACGPQDRQG----IVHRL 130

Query: 54  DRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIA 112
           D  TSG++++  S  A   L   F    I KRY A+V+G+      V++ P+  +L K  
Sbjct: 131 DANTSGLMVLAKSDLAYHNLKAAFRDRAIHKRYKALVQGYPDPSSGVINAPIGRDL-KHR 189

Query: 113 DKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLR 172
           D+F  +  G + AVT Y   +T E+      YP   + L+ + PKTGR HQ+R H + LR
Sbjct: 190 DRFCIDYSG-RDAVTQY---STEEV------YPG--FTLLSVAPKTGRTHQIRVHFSALR 237

Query: 173 HPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTG 214
           HP++GD K+G    +   ++   L+R  LHA  LS THP +G
Sbjct: 238 HPLVGDVKYG---ADPVFSQKVNLKRQWLHAYHLSFTHPVSG 276


>UniRef50_Q7NBQ4 Pseudouridine synthase n=1 Tax=Mycoplasma gallisepticum
           RepID=Q7NBQ4_MYCGA
          Length = 312

 Score = 98.6 bits (244), Expect = 2e-19,   Method: Compositional matrix adjust.
 Identities = 71/235 (30%), Positives = 121/235 (51%), Gaps = 27/235 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           L+I+Y+D+ L+ VNKP+  L H +  +  + ++      ++  Q V+ AHRLD+ T+G++
Sbjct: 84  LDIVYEDDDLIIVNKPTNMLSHPTTHNEPDTLLNCLMYHNK-KQKVYLAHRLDKDTTGLI 142

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE--AVLDYPL--VEELDKIADKFAR 117
           +   + +A   + +Q  + +I KRY+  +  +   E  AV+D P+  +++ D    KF  
Sbjct: 143 VATKNFKALEKIQEQITK-RIMKRYYLAIVHYPFNELRAVIDAPIGYLKDHDL---KFGV 198

Query: 118 ED-KGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPII 176
           E+ K P+ A+T    L               +Y L++ E  TGR HQ+R H+  ++H II
Sbjct: 199 ENTKNPKNAITKIYVLDQ-----------NKKYALIKCELLTGRTHQIRVHMDFIKHNII 247

Query: 177 GDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
            D  +G   + R+  + F      LHA QL LTHP T   L      D+ +M+ L
Sbjct: 248 NDPLYGVKGEQRTDYKQF------LHAYQLELTHPTTNVSLFFEVKPDEVFMKKL 296


>UniRef50_C0R043 Pseudouridine synthase n=2 Tax=Brachyspira RepID=C0R043_BRAHW
          Length = 217

 Score = 98.2 bits (243), Expect = 3e-19,   Method: Compositional matrix adjust.
 Identities = 60/233 (25%), Positives = 116/233 (49%), Gaps = 26/233 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           ++I+Y+D + +A++K +G  V  + ++      +++     I  +++  HR+D+ TSG++
Sbjct: 1   MKIIYEDNYFIAIDKEAGIEVDDNLIN------IIKKEYSHI-DNLYLVHRIDKFTSGIV 53

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADKFAREDK 120
           ++    E  +     F+   I K YHAIV G + +E   +D  +  +      +     K
Sbjct: 54  ILARDEETKKYFEDAFKNKTINKVYHAIVNGKVKKENGTIDISIGIDKKNPNRRIPLSIK 113

Query: 121 -GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDS 179
            G + A+THY+ L  +             + L+EL+P TGR HQ+R HL+++ HPIIGD 
Sbjct: 114 EGGESAITHYKVLKRL-----------NEHTLLELKPLTGRTHQIRVHLSYIGHPIIGDK 162

Query: 180 KHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALS 232
            +         A+ + ++   L A ++   HPFT + + I+   +  ++  L 
Sbjct: 163 IYS------KNADIYKMKGFALIAKEIHFVHPFTKKDIDINIKYNKEFLIRLK 209


>UniRef50_D0XS67 Pseudouridine synthase n=1 Tax=Brevundimonas subvibrioides ATCC
           15264 RepID=D0XS67_9CAUL
          Length = 350

 Score = 98.2 bits (243), Expect = 3e-19,   Method: Compositional matrix adjust.
 Identities = 76/244 (31%), Positives = 112/244 (45%), Gaps = 34/244 (13%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLM 63
           ++Y+D+ ++A+NKP G  V +        V  + +   +  +     HRLDR TSGVLL+
Sbjct: 113 VIYEDDLVIALNKPWGLAV-QGGTKTTRHVDRLLSAWGEGMERPRLVHRLDRDTSGVLLL 171

Query: 64  GLSSEAGRLLAQQFEQHQIQKRYHAIVRGW-----------LMEEAVLDYPLVEELDKIA 112
           G   EA + LA  F + Q +K Y AIV G            L +  + DY ++   D   
Sbjct: 172 GKGPEAAKRLAGAFARRQAKKTYWAIVMGLPKPADGQISVHLKKSGINDYEIMRPADP-- 229

Query: 113 DKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLR 172
                +D G +PA T Y          A   +   R   + L P TGR HQLR H+  + 
Sbjct: 230 -----KDPGAEPAETAY----------AVISHAAQRASWMALRPFTGRTHQLRAHMKAIG 274

Query: 173 HPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALS 232
           HPI+GD K+GD     +  +  G  +L LHA ++ L HP  G  L + A +         
Sbjct: 275 HPILGDPKYGD----DASTQLSGPLKLQLHARRIELDHPAGGT-LVVEAPISAELRAGFE 329

Query: 233 QFGW 236
            FG+
Sbjct: 330 HFGF 333


>UniRef50_C1ZGS9 Pseudouridine synthase n=1 Tax=Planctomyces limnophilus DSM 3776
           RepID=C1ZGS9_PLALI
          Length = 345

 Score = 98.2 bits (243), Expect = 3e-19,   Method: Compositional matrix adjust.
 Identities = 84/256 (32%), Positives = 126/256 (49%), Gaps = 24/256 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLD-RDEKVVVMQ----TVRDQIGQH-VFTAHRLDR 55
           L+ILY DE+L  +NK +  +VH    + R      +Q    ++ D  GQ+     HRLDR
Sbjct: 91  LDILYDDEYLCVINKTANMIVHPGRGNYRGTLAGALQFHFDSLSDVAGQYRAGIVHRLDR 150

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKF 115
            TSGVL++   +   + L++QFE+  ++K YHAIV G +  +A  DY  VE   +++ + 
Sbjct: 151 DTSGVLVVAKDNTVHQHLSRQFEERSVEKEYHAIVWGEMQFDA--DY--VETYVRVSFR- 205

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
            RE     P   + R  AT        R+    Y  V+L+P+TGR HQLR H+ HL HPI
Sbjct: 206 NRERMMVCPPGDNARQAATFYE--VQQRFRGFTY--VKLQPQTGRTHQLRVHMHHLGHPI 261

Query: 176 IGDS--------KHGD-LRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDT 226
           I D         K  D L +    A+   + R  LHA +L+  HP T + +   A L   
Sbjct: 262 IADRLYEGKTCVKLSDILPETPEEADETLIDRQALHARRLAFNHPVTKKRMVFEAPLPAD 321

Query: 227 WMQALSQFGWRGLLPE 242
           + + L       + P+
Sbjct: 322 FQKTLDTLKTHAIKPK 337


>UniRef50_C0GNZ6 Pseudouridine synthase, RluA family n=1 Tax=Desulfonatronospira
           thiodismutans ASO3-1 RepID=C0GNZ6_9DELT
          Length = 535

 Score = 98.2 bits (243), Expect = 3e-19,   Method: Compositional matrix adjust.
 Identities = 75/227 (33%), Positives = 117/227 (51%), Gaps = 30/227 (13%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV----------VMQTVRDQIGQHVFTAH 51
           L+I+Y D  +V +NKP+G  VH S  D    +V           + T R + G      H
Sbjct: 83  LDIVYMDREMVVLNKPAGLSVHPSSSDPAPTLVHYLLYACPGLRLMTDRQRPG----IVH 138

Query: 52  RLDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDK 110
           RLD+ T+G+++  L+ EA   LA QF   ++ K Y A+V G L  +E +++ PL  +   
Sbjct: 139 RLDKDTTGLMVAALNQEAKEDLAGQFAGRRVHKTYLALVCGALKQDEGIINVPLARDQQS 198

Query: 111 IADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAH 170
            A + A   +G + A T Y+ L          R P+  + LV+++  TGR HQ+R H +H
Sbjct: 199 RA-RVAPSREG-RSARTAYKVLK---------RDPSGLWSLVQVQIFTGRTHQIRVHFSH 247

Query: 171 LRHPIIGDSKHGDLRQNRSGAEHFGLQRL----MLHASQLSLTHPFT 213
           L HP++GD  +G    +R G +   L RL    +LH+S L + HP +
Sbjct: 248 LNHPVLGDRIYGGTDWDRFGWKKRFLSRLAKRQLLHSSCLGIMHPVS 294


>UniRef50_Q2NIN6 Pseudouridine synthase n=4 Tax=Candidatus Phytoplasma
           RepID=Q2NIN6_AYWBP
          Length = 306

 Score = 97.8 bits (242), Expect = 3e-19,   Method: Compositional matrix adjust.
 Identities = 67/241 (27%), Positives = 119/241 (49%), Gaps = 31/241 (12%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG--QHVFT-----AHRLD 54
           L+I+Y+D +L  +NKP+  +VH S     +K  ++  +  Q     H+ T      HRLD
Sbjct: 82  LDIIYEDPYLAVINKPANLVVHPSL--SFQKTTLVNGLLHQFNTLSHIDTQRPGIVHRLD 139

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPL-VEELDKIAD 113
           + T+G+L++  +++    L   F+Q +I K Y A++ G+L ++ ++  P+     +++  
Sbjct: 140 KNTTGLLIVAKTNDVSDKLQIAFQQRKITKIYWALIEGFLEDKGIIKLPIGRNNHNRLKM 199

Query: 114 KFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
           +   + K    AVTH++ L          R+  + + L+E   +TGR HQLR H + L+H
Sbjct: 200 QVMPDGKT---AVTHFKTLQ---------RF--SHFSLMECNLETGRTHQLRAHFSFLKH 245

Query: 174 PIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           PI+GD  +         + H       LH+  L   HP T + L + A L   + + L  
Sbjct: 246 PIVGDLLY-------DSSHHITPLGQFLHSKILKFNHPITNQNLILEAPLPTNFEKLLKT 298

Query: 234 F 234
           F
Sbjct: 299 F 299


>UniRef50_Q03WF6 Pseudouridine synthase n=9 Tax=Firmicutes RepID=Q03WF6_LEUMM
          Length = 312

 Score = 97.8 bits (242), Expect = 3e-19,   Method: Compositional matrix adjust.
 Identities = 73/230 (31%), Positives = 120/230 (52%), Gaps = 27/230 (11%)

Query: 13  AVNKPSGWLVHRSWLDRDEKVVV-------MQTVRDQIGQHVFTAHRLDRPTSGVLLMGL 65
            VNKP G +VH +       +V        + T+  +    +   HR+DR TSG+L++  
Sbjct: 90  VVNKPQGMVVHPAAGHSSGTLVNALLHHSPLSTINGEFRPGI--VHRIDRDTSGLLMVAK 147

Query: 66  SSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEA-VLDYPLVEELDKIADKFAREDKGPQP 124
           + +A R L++Q + H+ Q+ Y+A+VRG   E++  ++ P+     KI  K     +G + 
Sbjct: 148 NDKAHRSLSEQLKSHKNQRVYYALVRGEFTEDSGTIEAPIGRH--KIDRKKQAVIEGGRE 205

Query: 125 AVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHGDL 184
           AVTH+R L          RY    Y L+++  +TGR HQ+R H++++ HP++GD  +G  
Sbjct: 206 AVTHFRVLK---------RY--VGYTLLKVSLETGRTHQIRVHMSYIGHPVVGDPVYGTA 254

Query: 185 RQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
            Q   G +   L   +LHA  L+L  P TG+ L+  + L D +  ALS  
Sbjct: 255 -QKLDGTQ---LNGQLLHAKTLTLEQPTTGDELSFDSPLPDYFQFALSTL 300


>UniRef50_B8FTI5 Pseudouridine synthase n=2 Tax=Desulfitobacterium hafniense
           RepID=B8FTI5_DESHD
          Length = 302

 Score = 97.8 bits (242), Expect = 3e-19,   Method: Compositional matrix adjust.
 Identities = 78/240 (32%), Positives = 113/240 (47%), Gaps = 29/240 (12%)

Query: 2   LEILYQDEWLVAVNKPSGWLVH---RSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTS 58
           LEILY+D++ +A+NKP+G +VH   R         VV   +     +     HR+DR TS
Sbjct: 83  LEILYEDDYFIAINKPAGQVVHPTPRYPRGTIGNAVVGYWLAKGEARPFRPIHRIDRNTS 142

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADKFAR 117
           GV+++G +  A + +A Q    +I K Y  IV G +ME +  +  P+        D F +
Sbjct: 143 GVVVIGKNQFAHQQMAWQHAHGRIHKCYRGIVEGQVMEDQGTIKAPIA----LAPDSFIQ 198

Query: 118 EDKGPQ--PAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
               P+  PAVT Y+ L          RY      L+E   +TGR HQ+R H  HL HP+
Sbjct: 199 RQISPEGSPAVTLYKVLE---------RYQDA--SLLEFILETGRTHQIRVHCQHLGHPL 247

Query: 176 IGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFG 235
           +GD  +        G     + R  LH+S     HP TGE  TI A L +   + L +  
Sbjct: 248 LGDDLY--------GGNLARINRQALHSSIYEFNHPLTGELTTIQAPLPEDLQRLLRELA 299


>UniRef50_Q12L72 Pseudouridine synthase n=17 Tax=Shewanella RepID=Q12L72_SHEDO
          Length = 230

 Score = 97.8 bits (242), Expect = 3e-19,   Method: Compositional matrix adjust.
 Identities = 75/214 (35%), Positives = 109/214 (50%), Gaps = 26/214 (12%)

Query: 2   LEILYQDEWLVAVNKPSGWLVH--RSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSG 59
           L+I Y D  ++ +NKPSG L +  R+    D  +  +Q +  +        HRLD  TSG
Sbjct: 27  LDIRYLDRDIIVINKPSGLLSNPGRAPETYDTAITRLQRLYPE----TILIHRLDCDTSG 82

Query: 60  VLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADKFARE 118
           +++   + +A   L  QF+  Q +K Y A V G    ++  +++PL    D +   F + 
Sbjct: 83  IMIFARNKKAESNLKTQFQNRQAKKVYIAEVSGCFEHQDGKVNFPLGP--DPMTPPFQQV 140

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
            +  +PA+T+YR L   E   +T         LVEL+P TGR HQLR H+  L H IIGD
Sbjct: 141 IESGKPALTYYRLL---EHRASTS--------LVELKPHTGRTHQLRVHMKALGHTIIGD 189

Query: 179 SKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPF 212
             +GD  +    A H    RL LHA  L+L HPF
Sbjct: 190 EFYGD--ETVIAASH----RLNLHAQSLTLLHPF 217


>UniRef50_C6E472 Pseudouridine synthase n=4 Tax=Geobacter RepID=C6E472_GEOSM
          Length = 302

 Score = 97.4 bits (241), Expect = 4e-19,   Method: Compositional matrix adjust.
 Identities = 73/258 (28%), Positives = 127/258 (49%), Gaps = 44/258 (17%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVV-----MQTVRDQIGQHVFTAHRLDRP 56
           L+IL++D W++++NK  G  VHR+  D DE  +V     +   RD +G+ +   +RLD+ 
Sbjct: 78  LDILFEDSWIISLNKAPGLSVHRTE-DPDEVNLVDLAETLLQKRDGVGR-LRPVNRLDKG 135

Query: 57  TSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFA 116
           TSG +++  S+ A  +  +  ++  + K Y A+V G L ++ V+D PL            
Sbjct: 136 TSGAIILAKSAVAAGMFGKMVQEEGLGKLYLALVEGKLQKQGVIDAPLD----------G 185

Query: 117 REDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPII 176
           +E +     + H  G++                 L+ + P TGR HQ+R+H   + HPI+
Sbjct: 186 KESQTSYLRLFHGGGVS-----------------LLAVYPITGRMHQIRQHFKMIGHPIL 228

Query: 177 GDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGW 236
           GD ++G       G    G     LH+ + +L HP TGE + I A L +  M+ +S++  
Sbjct: 229 GDKRYG-------GRALTGFTGHALHSFKTTLVHPATGEEVNIPAPLPEQLMRLVSRYSG 281

Query: 237 ---RGLLPENERVEFSAP 251
              + LL   +++  S P
Sbjct: 282 VSEKALLDTLDQLPASGP 299


>UniRef50_A7ZDY2 Pseudouridine synthase n=4 Tax=Epsilonproteobacteria
           RepID=A7ZDY2_CAMC1
          Length = 252

 Score = 97.4 bits (241), Expect = 4e-19,   Method: Compositional matrix adjust.
 Identities = 66/205 (32%), Positives = 104/205 (50%), Gaps = 38/205 (18%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLM 63
           ++++DE L+A+NKP+            EK+        QI +     HRLD+ TSGVLL+
Sbjct: 60  VIFEDENLIAINKPAAI--------TSEKI-------SQIYKFPLL-HRLDKDTSGVLLL 103

Query: 64  GLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKGPQ 123
             + E   L   +F++ +++K Y A VRG + EE V++ P++   +K    F++  K  +
Sbjct: 104 VKNDEFASLAINEFKKMKVEKIYVAAVRGIMSEEVVVNEPILTIKNK-NGAFSKISKDGK 162

Query: 124 PAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHGD 183
            A++    L  V            +  LV++  KTGR HQ+R HLA L  PI+GD K+G 
Sbjct: 163 EAISEISPLMVV-----------GKKTLVKVVIKTGRTHQIRVHLASLNLPIVGDEKYGK 211

Query: 184 LRQNRSGAEHFGLQRLMLHASQLSL 208
            R N          R+ LHA  ++L
Sbjct: 212 NRAN----------RMFLHAYSIAL 226


>UniRef50_C6BRU5 Pseudouridine synthase n=1 Tax=Desulfovibrio salexigens DSM 2638
           RepID=C6BRU5_DESAD
          Length = 214

 Score = 97.1 bits (240), Expect = 5e-19,   Method: Compositional matrix adjust.
 Identities = 82/226 (36%), Positives = 114/226 (50%), Gaps = 34/226 (15%)

Query: 1   MLEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTA-HRLDRPTSG 59
           +L+I+Y D  +V VNKPSG L        ++  VV +  +       F A HRLD  TSG
Sbjct: 6   LLDIVYADRKIVVVNKPSGLLSVPGRGPENQDCVVTRVQKMFPECRKFPAVHRLDMDTSG 65

Query: 60  VLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARED 119
           +L++GL++ A R L +QF++ Q++KRY A++ G + E++      V E+    D + R  
Sbjct: 66  LLVLGLTARAVRELMEQFQKRQVKKRYEALLEGIVKEDSG-----VIEMAFRLDPYNRPY 120

Query: 120 KGPQP-----AVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAH---L 171
           +   P      +TH+R L      V  G    TR   VE  P TGR HQLR H AH   L
Sbjct: 121 QVYDPIHGKLGITHWRKLG-----VENG---MTR---VEFTPLTGRTHQLRVHSAHPQGL 169

Query: 172 RHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPL 217
             PI+GD  +G      SG E     +L LHA  L   HP T E +
Sbjct: 170 GCPIVGDRLYG------SGTEP---GQLKLHAGYLCFEHPKTKEKM 206


>UniRef50_A3EQJ0 Pseudouridine synthase n=1 Tax=Leptospirillum rubarum
           RepID=A3EQJ0_9BACT
          Length = 339

 Score = 97.1 bits (240), Expect = 5e-19,   Method: Compositional matrix adjust.
 Identities = 74/252 (29%), Positives = 116/252 (46%), Gaps = 36/252 (14%)

Query: 2   LEILYQDEWLVAVNKPSGWLVH------------------RSWLDRDEKVVVMQTVRDQI 43
           LEILY+DE L+ ++KP G +VH                  +S  D  +K    +    + 
Sbjct: 95  LEILYEDEDLIVISKPPGLVVHPAPGHSSGTLVNGLLFHFQSQGDEQKKGEPEEEEEAER 154

Query: 44  GQHVFTAHRLDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDY 102
                  HRLD+ TSGV+++G +      L  QF+   + K+Y A+V+G L ++   ++ 
Sbjct: 155 PLRAGLVHRLDQDTSGVMVVGKTESVVLDLMNQFKDRSVSKKYLALVKGILPKKRGEINA 214

Query: 103 PLVEELDKIADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKH 162
           P+            R+D   +P+VT YR L T              Y L+E+   TGR H
Sbjct: 215 PIGRSTHDRKKFTVRQDG--KPSVTRYRVLETYH----------ENYSLLEVTLLTGRTH 262

Query: 163 QLRRHLAHLRHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAG 222
           Q+R H  +L  P++GD+ +G       G E+    R MLHA +LS  HP +   +   A 
Sbjct: 263 QIRVHFRYLGFPLLGDAVYGS-----KGTENKNFPRQMLHAWKLSFQHPSSNSKMEFEAP 317

Query: 223 LDDTWMQALSQF 234
           L   ++ AL + 
Sbjct: 318 LPPDFVSALERL 329


>UniRef50_C9RKF9 Pseudouridine synthase n=1 Tax=Fibrobacter succinogenes subsp.
           succinogenes S85 RepID=C9RKF9_FIBSS
          Length = 386

 Score = 97.1 bits (240), Expect = 5e-19,   Method: Compositional matrix adjust.
 Identities = 70/224 (31%), Positives = 108/224 (48%), Gaps = 38/224 (16%)

Query: 2   LEILYQDEWLVAVNKPSGW-------------LVHRSW-LDRDEKVVVMQTVRDQIGQHV 47
           L+++ Q E  V VNKPSG              LV   W   R+E +    T+        
Sbjct: 143 LDLVVQTEDYVIVNKPSGLASQPGSGTRPGESLVEYLWEWGRNEGLDFKPTI-------- 194

Query: 48  FTAHRLDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVE 106
             AHRLD+ TSG+++  L  +  R   +   +H + K Y A+V+G L ++   +   L+ 
Sbjct: 195 --AHRLDQETSGLIIAALHGDTLRDFTRMIREHVVDKFYFALVKGNLKKDRGTISESLLR 252

Query: 107 ELDKIADKF--AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQL 164
                  K    ++D+  Q A+THYR     E            Y LV+++ +TGR HQ+
Sbjct: 253 TDSAKGSKMLVGQDDENAQKAITHYRVKQHYEG-----------YDLVKIKLETGRMHQI 301

Query: 165 RRHLAHLRHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSL 208
           R H A + HP++GD+++GD   NR   + FGL RL LH+ +L  
Sbjct: 302 RAHFASIGHPLLGDTRYGDFALNREVKKLFGLNRLFLHSCRLEF 345


>UniRef50_B5YKV0 Pseudouridine synthase n=1 Tax=Thermodesulfovibrio yellowstonii DSM
           11347 RepID=B5YKV0_THEYD
          Length = 315

 Score = 97.1 bits (240), Expect = 6e-19,   Method: Compositional matrix adjust.
 Identities = 65/244 (26%), Positives = 117/244 (47%), Gaps = 32/244 (13%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVF------------T 49
           ++++Y+D++L+ ++KP+G +V+      D       T+ + +  HV              
Sbjct: 82  IQVIYKDDYLIVLSKPAGMVVYPCAGHPD------GTLMNALAYHVKKLANVGAPFRPGI 135

Query: 50  AHRLDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEEL- 108
            HRLD+ TSGV+++ L  E    L + F++ +I+K Y A+V G L     +  P+   + 
Sbjct: 136 VHRLDKDTSGVMVVALDDETYYKLVEAFKKREIKKEYLALVYGQLRGSGKITTPVGRAIY 195

Query: 109 DKIADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHL 168
           D+   K + + K  + A+T +  +   +            Y  ++++  TGR HQ+R H 
Sbjct: 196 DR--KKMSIKSKKAKEAITEWEVIKNFK-----------NYTFLKVKILTGRTHQIRVHF 242

Query: 169 AHLRHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWM 228
           + + HP+IGD  +G       G +   + R MLHA ++ L HP T + L   A L D   
Sbjct: 243 SSIGHPVIGDKTYGRKTYIEIGNKKIPVSRQMLHAHKIELIHPITEKLLQFEASLPDDIQ 302

Query: 229 QALS 232
             L+
Sbjct: 303 YILN 306


>UniRef50_B7BE87 Pseudouridine synthase n=8 Tax=Bacteroidales RepID=B7BE87_9PORP
          Length = 551

 Score = 97.1 bits (240), Expect = 6e-19,   Method: Compositional matrix adjust.
 Identities = 86/238 (36%), Positives = 110/238 (46%), Gaps = 39/238 (16%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQI--GQHVFTAHRLDRPTSG 59
           LEI+Y+DE L+ VNKP+G L      D D    V Q VR            HRLD  TSG
Sbjct: 337 LEIVYEDESLLVVNKPAGMLSVPGKSDVDS---VYQRVRRMYPGATGPMVVHRLDMATSG 393

Query: 60  VLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADKFARE 118
           ++L+  + E  + L  QF+   + KRY A + G + E E  L+ PL  + +    +    
Sbjct: 394 LMLVAKTKEVHQNLQAQFKNRTVCKRYVAWLDGIVEEKEGHLELPLRPDPEDRPRQVVDV 453

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGL------VELEPKTGRKHQLRRHLAH-- 170
             G +PAVT YR L          RY   + GL      V   PKTGR HQLR H AH  
Sbjct: 454 VHG-KPAVTDYRVL----------RYGGCKGGLRTTPTVVSFVPKTGRTHQLRVHSAHPL 502

Query: 171 -LRHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTI--HAGLDD 225
            L  PI+GD  +G               RL LHA  L  THP +G  + +   AG DD
Sbjct: 503 GLNAPIVGDELYGK-----------KADRLYLHAEYLGFTHPVSGVYMEVEKEAGFDD 549


>UniRef50_A6VZC6 Pseudouridine synthase n=2 Tax=Marinomonas RepID=A6VZC6_MARMS
          Length = 212

 Score = 97.1 bits (240), Expect = 6e-19,   Method: Compositional matrix adjust.
 Identities = 70/214 (32%), Positives = 106/214 (49%), Gaps = 24/214 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWL-VHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGV 60
           LEILY+DEW   +NKP+  L V     D+ + ++      + +    F  HRLD  TSG+
Sbjct: 9   LEILYEDEWFAVINKPANCLSVPGRGPDKLDSILYRA---ECLFGEAFAIHRLDEATSGL 65

Query: 61  LLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADKFARED 119
           +L+  + E  + +   F + ++QK Y A++RG L+ E+  +  PL  +      +    D
Sbjct: 66  ILVAKTHECQKRMYAHFREREVQKEYRALLRGHLLGEKGEVRKPLRCDWPNRPRQIICTD 125

Query: 120 KGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDS 179
           +  + ++T++  +A            TTR   V L P TGR HQLR H+  L H IIGD 
Sbjct: 126 EWSKDSITYWEKMAYENN--------TTR---VRLVPFTGRSHQLRVHMQSLGHSIIGDE 174

Query: 180 KHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFT 213
            +    QN          RL+LHA +L   HPFT
Sbjct: 175 FYDPEFQNDP--------RLLLHAYRLEFRHPFT 200


>UniRef50_C0FY60 Pseudouridine synthase n=1 Tax=Roseburia inulinivorans DSM 16841
           RepID=C0FY60_9FIRM
          Length = 294

 Score = 96.7 bits (239), Expect = 6e-19,   Method: Compositional matrix adjust.
 Identities = 66/220 (30%), Positives = 112/220 (50%), Gaps = 23/220 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSW---LDRDEKVVVMQTVRDQIGQHVF------TAHR 52
           L+++Y+D+ ++ +NKPSG L  ++    +  +E ++     +  + +  F        +R
Sbjct: 59  LQVVYEDDDVIIINKPSGMLSQKAVPEDISANEYILSYLIRKGALSEEQFKTFKPSICNR 118

Query: 53  LDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIA 112
           LDR TSG+L+ G + +  + +A+  ++  +QK Y  IV+G L E+  L   L ++     
Sbjct: 119 LDRNTSGLLIAGKTLKGLQTMAEALKKRTVQKYYRCIVKGELREKTHLKGYLSKD----- 173

Query: 113 DKFAREDKGPQPAVTHYRGLATVE-MPVATGRYPT-TRYGLVELEPK--TGRKHQLRRHL 168
                E       V+H R     + +P+ T   P     G  ELE    TGR HQ+R HL
Sbjct: 174 -----EQNNKVKVVSHIRPEEKADYLPIETEYRPVAVSNGYTELEVHLITGRSHQIRAHL 228

Query: 169 AHLRHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSL 208
           A + HPI+GD K+GDLR N    +   ++  +LHA ++ L
Sbjct: 229 ASIGHPIVGDGKYGDLRTNERFRKEVHVRSQLLHAYRIVL 268


>UniRef50_A9BWX6 Pseudouridine synthase n=2 Tax=Comamonadaceae RepID=A9BWX6_DELAS
          Length = 245

 Score = 96.7 bits (239), Expect = 6e-19,   Method: Compositional matrix adjust.
 Identities = 74/229 (32%), Positives = 116/229 (50%), Gaps = 24/229 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           +  LY+D  L+ ++KPSG L         +  +  + +  Q        HRLD+ TSG++
Sbjct: 32  VSCLYEDAELLVLDKPSGLLCVPGRGPDKQDCLSGRAL--QRWPDALVVHRLDQATSGLV 89

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAV-----LDYPLVEELDKIADKFA 116
           +M  S  + RLL++ F Q ++ K Y A+V G    +       +D P+  + ++   +  
Sbjct: 90  VMARSLASQRLLSEAFAQRRVHKLYVAVVAGRPAAQQADAWQSIDLPIAADWERRPLRII 149

Query: 117 REDKGPQPAVTHYRGLATVEMPVATGRY--PTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
              +G +P+ T +R      MP AT  +  PTTR   V+L+P TGR HQLR H+A L H 
Sbjct: 150 DALQG-KPSQTLWRA-----MPAATEGHDTPTTR---VQLQPVTGRTHQLRVHMAALGHA 200

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGL 223
           I+GD+ + D       A      RL+LHA QL L HP +G+ L   + +
Sbjct: 201 ILGDALYAD------AAVQALSPRLLLHAHQLELAHPLSGQTLRFESAV 243


>UniRef50_B7GAM3 Predicted protein (Fragment) n=1 Tax=Phaeodactylum tricornutum CCAP
           1055/1 RepID=B7GAM3_PHATR
          Length = 325

 Score = 96.7 bits (239), Expect = 7e-19,   Method: Compositional matrix adjust.
 Identities = 68/235 (28%), Positives = 113/235 (48%), Gaps = 23/235 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV-----VMQTVRDQIGQHVFTAHRLDRP 56
           L+I+++DE ++ +NK +  +VH +  + D  VV      +    + I       HRLD+ 
Sbjct: 73  LDIIFEDEHMIVINKAANMVVHPAAGNWDGTVVNALAYYLANRSESISFRPGIVHRLDKG 132

Query: 57  TSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPL------VEELDK 110
           T+GVL++  +S+    L+  F   Q++K Y AI  G   +  V+D P+       + +  
Sbjct: 133 TTGVLVVAKTSQTLATLSNFFAARQVKKTYMAITVGNPGKHVVIDKPIGRHPLHRQRMRV 192

Query: 111 IADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAH 170
           + D   +   G        R L+ V+     G+       LV++  +TGR HQ+R HL  
Sbjct: 193 VPDPHQKNSTG-------RRALSYVDTLAFDGKL-----SLVQVRIETGRTHQIRVHLQD 240

Query: 171 LRHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDD 225
              PI GD  +G    N+  ++   + R +LHA +L + HP TGEP+   A L D
Sbjct: 241 RHTPIYGDDIYGLADWNKKLSKTHRIVRPLLHAYKLEINHPVTGEPMVFKASLAD 295


>UniRef50_C0F0M1 Putative uncharacterized protein n=1 Tax=Eubacterium hallii DSM
           3353 RepID=C0F0M1_9FIRM
          Length = 306

 Score = 96.7 bits (239), Expect = 7e-19,   Method: Compositional matrix adjust.
 Identities = 72/232 (31%), Positives = 120/232 (51%), Gaps = 31/232 (13%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLD-RDEKVVVMQTVRDQIGQ------HVFTAHRLD 54
           L ILY+DE L+ V+KP+G + H S     D  +  +Q   +  G+      ++    RLD
Sbjct: 83  LHILYEDEDLIFVDKPAGIVSHPSKGHLSDSMINGVQAYFENEGREKNERSNIHLIGRLD 142

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVE-----ELD 109
           + TSG+L +  +S     + +Q ++  + K Y+A+V+G   EE +L+ P+ E     + D
Sbjct: 143 KETSGILGIAKNSVTAERMIKQRQRGILIKEYYALVKGNPPEEGILEIPMEEMRDARDGD 202

Query: 110 KIADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLA 169
           K+  K  + +   + A T ++ +   E           ++ LV L  +TGR HQ+R H+A
Sbjct: 203 KLKMKVGKSENA-KTAKTFFQVVKRFE-----------KFSLVSLVIETGRTHQIRFHMA 250

Query: 170 HLRHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHA 221
            +  P++GDS +GD      G E  G+ R  LHA QL+ THPF  + + I +
Sbjct: 251 SIGCPLLGDSFYGD------GPE-LGISRTALHAQQLTFTHPFCEKVMRIES 295


>UniRef50_D0BL50 Pseudouridine synthase n=1 Tax=Granulicatella elegans ATCC 700633
           RepID=D0BL50_9LACT
          Length = 296

 Score = 96.7 bits (239), Expect = 7e-19,   Method: Compositional matrix adjust.
 Identities = 77/230 (33%), Positives = 110/230 (47%), Gaps = 30/230 (13%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV-----VMQTVRDQ-IGQHVFTAHRLDR 55
           L+IL++D++L+ VNKP G     S L  D+ +       +QT R Q    HV T  RLDR
Sbjct: 77  LDILFEDDYLLIVNKPQGTASIPSQLHPDQSMANRVKGYLQTTRTQDCVTHVVT--RLDR 134

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIV--RGWLMEEAVLDYPLVEELDKIAD 113
            T+GV++          + Q      IQK YHAIV  +  L E  ++D P+    D I +
Sbjct: 135 DTTGVMMFAKHRVVHAWMDQALRNKTIQKTYHAIVTKQDVLKEHDLIDAPIGRTDDSIIN 194

Query: 114 KFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
           +  R D   +P++T Y    T +              LV++   TGR HQ+R H + L  
Sbjct: 195 RCVRPDG--KPSLTEYWLEETYQ-----------HSQLVKIRLHTGRTHQIRVHFSWLGC 241

Query: 174 PIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGL 223
           P++GD  +G       G +   L R  LH SQL   HP TGE + + A L
Sbjct: 242 PLLGDDLYG-------GEKIEPLMRQALHCSQLDFVHPMTGEKMCVKALL 284


>UniRef50_D1RB93 Pseudouridine synthase n=1 Tax=Parachlamydia acanthamoebae str.
           Hall's coccus RepID=D1RB93_9CHLA
          Length = 283

 Score = 96.7 bits (239), Expect = 7e-19,   Method: Compositional matrix adjust.
 Identities = 72/229 (31%), Positives = 111/229 (48%), Gaps = 20/229 (8%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLM 63
           ILY+D  LV + KP+G L   +  D+ +        R +  + V+  HRLD+ TSGV+L 
Sbjct: 70  ILYEDAHLVVIEKPAGLLSVATNFDKAKTAHAFLKERYR-PRKVYVVHRLDQDTSGVMLF 128

Query: 64  GLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADKFAREDKGP 122
            L+ EA   L   F  H I + Y A+V G +  +E      L E+   +       DKG 
Sbjct: 129 ALTGEAFFGLKALFADHDIDREYTAVVHGKMTQQEGTWQSYLYEDKAYVVHSTQDPDKG- 187

Query: 123 QPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHG 182
           + A+TH++   TVE          T + L+ L+ +TG+K+Q+R H      PI+GD K+G
Sbjct: 188 ELAITHFK---TVE--------ARTHFSLLNLKLETGKKNQIRVHCEDHGFPIVGDKKYG 236

Query: 183 DLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
                  G  H   +RL LHA  L   HP   + ++  + + + + Q L
Sbjct: 237 G-----EGESHI-TKRLCLHAHHLGFVHPIYKKEMSFDSPIPEKFYQCL 279


>UniRef50_C9KPZ8 Pseudouridine synthase n=1 Tax=Mitsuokella multacida DSM 20544
           RepID=C9KPZ8_9FIRM
          Length = 308

 Score = 96.3 bits (238), Expect = 8e-19,   Method: Compositional matrix adjust.
 Identities = 77/239 (32%), Positives = 117/239 (48%), Gaps = 22/239 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIGQH----VFTAHRLDR 55
           L+ILY+D  ++ +NK  G +VH +       +V  ++   +D  G +        HRLD+
Sbjct: 80  LDILYEDSDIIVINKARGMVVHPATGIYTGTLVNALLYHCKDLSGINGEIRPGIVHRLDK 139

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKF 115
            TSGV++   +  A   LA+Q       + Y AIV G + EEA +    +        K 
Sbjct: 140 DTSGVMVAAKNDAAHLDLAEQIRTKAAHRIYRAIVCGNIREEAGVIKGDIGRHPTDRKKM 199

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
           A   +  +PAVTH+R L          R+    Y LVE   +TGR HQ+R H+A + HP+
Sbjct: 200 AIVHEHGKPAVTHFRVLE---------RFGA--YTLVECRLETGRTHQIRVHMASIGHPV 248

Query: 176 IGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           +GD K+G  +     A  F ++   LH+ QL+LTHP T E +T  A L +   + L   
Sbjct: 249 LGDPKYGPRK-----ACPFAIKGQALHSLQLTLTHPRTREVMTFTAPLPEDMEKILKAL 302


>UniRef50_B1VEM5 Pseudouridine synthase n=3 Tax=Corynebacterium RepID=B1VEM5_CORU7
          Length = 313

 Score = 96.3 bits (238), Expect = 1e-18,   Method: Compositional matrix adjust.
 Identities = 78/226 (34%), Positives = 120/226 (53%), Gaps = 15/226 (6%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLM 63
           I+++D+ L+ VNKP+   VH     +   +  ++ +R +  + +  AHRLD+ TSG+L++
Sbjct: 96  IVFEDDDLLIVNKPANIAVHVGSGVKAGVIEALRVLRPE-DKELELAHRLDKETSGLLIV 154

Query: 64  GLSSEAGRLLAQQFEQ--HQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKG 121
             +S+  R L     +    IQ+ Y A+  G L +       +   L K       + + 
Sbjct: 155 AKNSKMLRHLQSLLREGGEDIQRYYLAVAGGVLKKSGKQARRIDAPLRKTGAATVVDRRA 214

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
            Q A T       V+ P   GR  T    LVE++  TGRKHQ+R HL HL HPIIGDS++
Sbjct: 215 GQQAETKL----WVKKP--WGRAGT----LVEVQLLTGRKHQIRVHLQHLGHPIIGDSRY 264

Query: 182 GDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTW 227
           GD   N++ AE  G++ LMLHAS+L +  P +GE L + A +   W
Sbjct: 265 GDKAANQAAAEK-GVRMLMLHASRLVIPLP-SGEELDVQAPMPPAW 308


>UniRef50_A5INM9 Pseudouridine synthase n=7 Tax=Thermotogaceae RepID=A5INM9_THEP1
          Length = 304

 Score = 95.9 bits (237), Expect = 1e-18,   Method: Compositional matrix adjust.
 Identities = 66/238 (27%), Positives = 110/238 (46%), Gaps = 40/238 (16%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQI-------GQHVFTAHRLD 54
           L++LY+ +  + +NKP    +H        K V + T+ + +       G   F  HRLD
Sbjct: 85  LDVLYEGKHYLVLNKPPNIAIHPG------KGVHVATLIEGLLHYGQEKGFSPFLVHRLD 138

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADK 114
           + TSG+L++    EA R+L + F+   I+K Y  +VRG       +  PL          
Sbjct: 139 KDTSGLLVVAKDREAARILTELFKDRNIEKEYVTLVRGTPENNMKITIPL---------- 188

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
                   Q A++    + ++               L+ ++  TGRKHQ+RRHL+ +  P
Sbjct: 189 ------DGQEAISEIVSVKSLR-----------DVSLLRVKIHTGRKHQIRRHLSQIGFP 231

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALS 232
           ++GD  +GD   NR   + +GL+RL LH+ ++    P+T E     A L D  +  L+
Sbjct: 232 VVGDDTYGDRHFNREFRKRYGLKRLFLHSYRMKFIDPWTEEEKDFRAPLPDDLLSVLN 289


>UniRef50_P54604 Uncharacterized RNA pseudouridine synthase yhcT n=5 Tax=Bacillus
           RepID=YHCT_BACSU
          Length = 302

 Score = 95.9 bits (237), Expect = 1e-18,   Method: Compositional matrix adjust.
 Identities = 72/224 (32%), Positives = 109/224 (48%), Gaps = 23/224 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG---QHVFTAHRLDRPTS 58
           L+IL++D  ++ +NKP+G   H +   +   +  +     QI      V   HRLD+ TS
Sbjct: 83  LDILFEDNHMLIINKPAGIATHPNEDGQTGTLANLIAYHYQINGETCKVRHVHRLDQDTS 142

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADKFAR 117
           G ++      A  +L QQ E+  +++ Y AI  G L  ++  ++ P+    D+      R
Sbjct: 143 GAIVFAKHRLAHAILDQQLEKKTLKRTYTAIAEGKLRTKKGTINSPIGR--DRSHPTRRR 200

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
              G Q AVTH++ +A+             R  LVELE +TGR HQ+R HLA L HP+ G
Sbjct: 201 VSPGGQTAVTHFKVMAS---------NAKERLSLVELELETGRTHQIRVHLASLGHPLTG 251

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHA 221
           DS +G       G     L R  LHA+++   HP T E +   A
Sbjct: 252 DSLYG-------GGSKL-LNRQALHANKVQAVHPITDELIVAEA 287


>UniRef50_C7MES4 Pseudouridine synthase, RluA family n=5 Tax=Actinomycetales
           RepID=C7MES4_BRAFD
          Length = 318

 Score = 95.9 bits (237), Expect = 1e-18,   Method: Compositional matrix adjust.
 Identities = 80/230 (34%), Positives = 113/230 (49%), Gaps = 21/230 (9%)

Query: 5   LYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLMG 64
           L++DE L+ ++KP+G  VHR        +  ++ +R ++   +   HRLDR TSGVL + 
Sbjct: 103 LHEDEDLLIIDKPAGVAVHRGTDVPAGVIDALRQLRPEL-PDLELIHRLDRSTSGVLALA 161

Query: 65  LSSEAGRLLAQQFE--QHQIQKRYHAIVRG-WLMEEAVLDYPLVEELDKIADKFAREDKG 121
            S    R L       + +I++RY A+V G W  E  +LD PL  E +++       D  
Sbjct: 162 KSPSMLRYLHDLLRDREDEIERRYLALVAGHWPAETTILDAPLRREENRVV-----VDPD 216

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
            Q A TH          VA  +    R  L+E+   TGRKHQ+R HL H  HPI GD ++
Sbjct: 217 GQRAETH----------VAVAQRFGNRATLLEVRLLTGRKHQIRVHLQHAGHPIAGDDRY 266

Query: 182 GDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
           GD   NR  A   G   L LHA++L +  P  G  L + A     W Q L
Sbjct: 267 GDDAFNRRAAS-LGGTGLHLHAAELVIPRP-DGTTLAVTAPTPRRWEQLL 314


>UniRef50_C8W9Q3 Pseudouridine synthase n=2 Tax=Atopobium RepID=C8W9Q3_ATOPD
          Length = 246

 Score = 95.9 bits (237), Expect = 1e-18,   Method: Compositional matrix adjust.
 Identities = 73/244 (29%), Positives = 122/244 (50%), Gaps = 23/244 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDR-------DEKVVVMQTVRDQIGQHVFTAHRLD 54
           LE LYQD++L+AVNKP+G +VH    +         EK+  +++        V   +RLD
Sbjct: 10  LEFLYQDDYLLAVNKPAGMIVHSDGTNEPSLTDLVCEKLCALESSNKIDLSQVQALNRLD 69

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRG-WLMEEAVLDYPLVEELDKIAD 113
           + T+G++L  L  E      Q     ++ K Y A+V+G + + + ++D  + ++    A 
Sbjct: 70  KETTGIVLFSLKKETQPQFDQLIASKELSKEYLAVVKGDFGLNKLLIDKAIGKDRHD-AQ 128

Query: 114 KFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
           K    D G +P+ T  R +       A G+  +    L+ +   TGRKHQ+R HL+ L  
Sbjct: 129 KMRISDTG-KPSQTEVRLIKVASS--AQGQIQS----LLLVNLLTGRKHQIRVHLSSLGF 181

Query: 174 PIIGDSKHGDLR--QNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
           P++GD  +G +   Q ++  +H   Q LMLHA ++   HP TG  + I   + + +    
Sbjct: 182 PLVGDVLYGGMSSLQRKTKKKHRP-QPLMLHAYRIGFIHPVTGAKIVIKTDIPERF---- 236

Query: 232 SQFG 235
           S FG
Sbjct: 237 SNFG 240


>UniRef50_B6J6C4 Pseudouridine synthase n=7 Tax=Coxiella burnetii RepID=B6J6C4_COXB1
          Length = 327

 Score = 95.9 bits (237), Expect = 1e-18,   Method: Compositional matrix adjust.
 Identities = 72/244 (29%), Positives = 112/244 (45%), Gaps = 48/244 (19%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRD---QIGQHVFTAHRLDRPTS 58
           L+++Y+DE L+ +NKP G +VH     RD+ ++      D    +       HRLD+ TS
Sbjct: 89  LDVIYEDETLLVINKPVGLIVHPGAGVRDQTLINALLHYDPSLSVVPRAGIIHRLDKDTS 148

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPL----VEELDKIADK 114
           G+LL+  +  +   L +  +  QI + Y AIV+G L+    ++ P+    +        +
Sbjct: 149 GLLLIARTLASHHALIKAMKARQIVREYEAIVKGVLISGRTIEAPVGRHPIHRTRMAVVE 208

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
           F R      PA+TH+R +          RY    +  V+LE  TGR HQ+R H+AH+ HP
Sbjct: 209 FGR------PAITHFRIIK---------RYRAHTHIRVQLE--TGRTHQIRVHMAHIHHP 251

Query: 175 IIGDSKHGDLRQNRSGAEHFG---------------LQRLMLHASQLSLTHPFTGEPLTI 219
           + GD  +G          H G               L+R  LH + L  +HP    P+  
Sbjct: 252 LAGDPVYGS---------HVGIPVHLSDPLQTALKTLKRQALHGATLQFSHPVDQRPMAC 302

Query: 220 HAGL 223
           HA L
Sbjct: 303 HAPL 306


>UniRef50_Q6MM51 Ribosomal large subunit pseudouridine synthase C n=1
           Tax=Bdellovibrio bacteriovorus RepID=Q6MM51_BDEBA
          Length = 231

 Score = 95.9 bits (237), Expect = 1e-18,   Method: Compositional matrix adjust.
 Identities = 79/232 (34%), Positives = 112/232 (48%), Gaps = 28/232 (12%)

Query: 1   MLEILYQDEWLVAVNKPSGWLVHRSWLDR---DEKVVVMQTVRDQIGQHVFTA--HRLDR 55
           M+EIL++DE+ +A  KP+G +  ++ +D+   D    +   +R++ G   + A  HRLDR
Sbjct: 1   MIEILFEDEFFLAAAKPAG-MPSQATVDKSRQDFFTALKNQLRNERGDAFYLALHHRLDR 59

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAV--LDYPLVEELDK--I 111
            TSGV++   + EA   LA  F+ H+IQK Y  + +          +D  LVE  D    
Sbjct: 60  DTSGVMIFAKTKEANEPLADLFKTHKIQKTYLCLTKRTQKAADAWEVDNHLVEMKDTKLK 119

Query: 112 ADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHL 171
             K  R   G   A T +R L     P A          L+E +P TGR HQ+R HLA  
Sbjct: 120 KTKMVRTQSGGDRAYTKFRKLEV--FPEAL---------LIEAQPLTGRMHQIRVHLADR 168

Query: 172 RHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGL 223
              I GD    D+ Q     ++    RLMLHA  L  THPFT E + I   +
Sbjct: 169 GMGIYGD----DIYQ---APKNPVAPRLMLHAHALEFTHPFTKEFVRIECAV 213


>UniRef50_Q2SK59 Pseudouridine synthase n=3 Tax=Gammaproteobacteria
           RepID=Q2SK59_HAHCH
          Length = 315

 Score = 95.9 bits (237), Expect = 1e-18,   Method: Compositional matrix adjust.
 Identities = 66/208 (31%), Positives = 103/208 (49%), Gaps = 14/208 (6%)

Query: 5   LYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLMG 64
           L++++ L+ +NKP G  VH         + +++  R  I + +  AHRLDR TSGVL++ 
Sbjct: 100 LFENDELLIINKPCGVAVHGGSGVSFGVIEILRAARQDI-RFLELAHRLDRDTSGVLVLA 158

Query: 65  LSSEAGRLLAQQFEQHQIQKRYHAIVRG-WLMEEAVLDYPLVEELDKIADKFAREDKGPQ 123
               A        +  +++K YHA V G W   ++V+  PL + + +  ++     +  +
Sbjct: 159 KKRRALVQFHDMLKTGRVEKIYHAWVCGKWPKHKSVITAPLKKNVLRSGERMVNVSEDGK 218

Query: 124 PAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHGD 183
           P+ T +R L           Y      LVE +P TGR HQ+R H     HPIIGD K+ D
Sbjct: 219 PSETRFRVL-----------YSGAGRTLVEAQPITGRTHQIRVHAKFAGHPIIGDDKYCD 267

Query: 184 LRQNRSGAEHFGLQRLMLHASQLSLTHP 211
              NR      G++RL LHA  L ++ P
Sbjct: 268 SETNRV-YRDMGVKRLCLHAYSLRMSWP 294


>UniRef50_B9XS18 Pseudouridine synthase n=1 Tax=bacterium Ellin514
           RepID=B9XS18_9BACT
          Length = 536

 Score = 95.5 bits (236), Expect = 1e-18,   Method: Compositional matrix adjust.
 Identities = 70/223 (31%), Positives = 106/223 (47%), Gaps = 32/223 (14%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLM 63
           IL++DE L+ VNKP+G   H       E +      R+     +   HRLD+ TSGV++ 
Sbjct: 12  ILFEDEHLLVVNKPAGMNTHAPSPYAGEGIYEWLKHREPRWASLAIVHRLDKETSGVMVF 71

Query: 64  GLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLD---YPLVEELDKIADKFARED- 119
           G ++ A R L +QF  H I+K+Y       L+ + V+      +V  L ++ +K+     
Sbjct: 72  GKTTVANRSLTEQFTNHSIRKKY------LLLTDKVVSSQTSTMVSCLVRVGEKYLSRPV 125

Query: 120 -KGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
             G + A TH+  +   E              LVE EP TGR HQ+R H A    PI+GD
Sbjct: 126 HAGGEKAETHFEVITKAEGGT-----------LVEAEPITGRTHQIRVHAAEQGFPILGD 174

Query: 179 SKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHA 221
           + +G  + +          R+ LHA++L L HP T   +T  A
Sbjct: 175 ALYGGTKAS----------RVCLHAAELKLKHPGTNAEMTFRA 207


>UniRef50_C0MA80 Pseudouridine synthase n=6 Tax=Streptococcus RepID=C0MA80_STRE4
          Length = 300

 Score = 95.5 bits (236), Expect = 1e-18,   Method: Compositional matrix adjust.
 Identities = 73/219 (33%), Positives = 108/219 (49%), Gaps = 28/219 (12%)

Query: 2   LEILYQDEWLVAVNKPSGWL-----VHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRP 56
           L+I+Y+DE  + +NKP+G+      +H + +    K   ++  +D   + V    RLDR 
Sbjct: 76  LDIVYEDEHFLILNKPAGYASIPSAIHSNTIANFIKAYYIK--QDYPNKQVHIVTRLDRD 133

Query: 57  TSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGW--LMEEAVLDYPLVEELDKIADK 114
           TSG++L      A   L +Q +Q  I KRY+A+V G   L ++  +  P+    D I  +
Sbjct: 134 TSGLMLFAKHGYAHARLDKQLQQRAINKRYYALVCGQERLPDQGEIIAPIGRTDDSIITR 193

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
                KG + A T Y+ +A         RYP     LV++   TGR HQ+R H AHL  P
Sbjct: 194 TVTP-KG-KYAKTSYKVIA---------RYPEN-VSLVDITLHTGRTHQIRVHFAHLGFP 241

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFT 213
           ++GD  +G       G    G+ R  LH   LS THPFT
Sbjct: 242 LLGDDLYG-------GRLDLGMTRQALHCHHLSFTHPFT 273


>UniRef50_B0JGC2 Pseudouridine synthase n=2 Tax=Microcystis aeruginosa
           RepID=B0JGC2_MICAN
          Length = 501

 Score = 95.5 bits (236), Expect = 1e-18,   Method: Compositional matrix adjust.
 Identities = 73/220 (33%), Positives = 111/220 (50%), Gaps = 26/220 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           LEI+Y+DE ++A+NKP+G L+  +   +D +  V+   R Q G+++   HRLDR TSG+L
Sbjct: 300 LEIIYEDEGIIAINKPAG-LLSVAGRYQDSQDAVVNRFRRQ-GKNLIPVHRLDRETSGIL 357

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEA-VLDYPLVEELDKIADKFAREDK 120
           L+  S +  R L+QQF++ +++K Y AI+   +  E+ ++D PL          +     
Sbjct: 358 LLAKSLDIYRCLSQQFQRREVEKIYEAILSEIIERESGIIDLPL----------WGNPQN 407

Query: 121 GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAH-LRHPIIGDS 179
            P   V   RG A+       G+     Y  +E  P TGR HQ+R H    L   I+GD 
Sbjct: 408 RPYQTVDWQRGKASQTYFKVVGK--EGNYSRLEFIPYTGRTHQIRVHSQQGLGIGILGDR 465

Query: 180 KHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTI 219
            +   + +          RL LHA QLS  HP T   L +
Sbjct: 466 LYNGKQSD----------RLHLHAKQLSFRHPQTENKLDL 495


>UniRef50_Q67N67 Pseudouridine synthase n=1 Tax=Symbiobacterium thermophilum
           RepID=Q67N67_SYMTH
          Length = 327

 Score = 95.5 bits (236), Expect = 2e-18,   Method: Compositional matrix adjust.
 Identities = 79/257 (30%), Positives = 123/257 (47%), Gaps = 60/257 (23%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTA---------HR 52
           ++++Y+D WL+ V+KP+G +VH     RD    V  T+ + +  H+  +          R
Sbjct: 74  IQVVYEDPWLLVVDKPAGMVVHPV---RD---YVSGTLANAVAHHLLRSGSDPVARPVQR 127

Query: 53  LDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRY----------------HAIVRGW--L 94
           +DR TSG++L         LLA++ E+ ++++RY                  I R W   
Sbjct: 128 IDRETSGLVLFAKDPAVAGLLARELERQKLERRYVAVVEGAVAADAGTVDRPIRRVWGHP 187

Query: 95  MEEAVLDYPLVEELDKIADKFA------RED--KGPQPAVTHYRGLATVEMPVATGRYPT 146
           +   V + P   E +++  + A      RED     QPAVTH+R L     P AT     
Sbjct: 188 VAREVAEGPRTPEQERLLAEAAAQGRALREDWTAAGQPAVTHWRVLR--RWPAAT----- 240

Query: 147 TRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQL 206
               ++EL  +TGR HQ+R H+A+L HP++GD  +G  R          +QR  LHA+ L
Sbjct: 241 ----MLELRLETGRTHQIRVHMAYLGHPLLGDELYGGSRTL--------IQRQALHAATL 288

Query: 207 SLTHPFTGEPLTIHAGL 223
           +  HP T EP+   A L
Sbjct: 289 AFVHPVTREPVRFTAPL 305


>UniRef50_A5EX53 Pseudouridine synthase n=1 Tax=Dichelobacter nodosus VCS1703A
           RepID=A5EX53_DICNV
          Length = 322

 Score = 95.5 bits (236), Expect = 2e-18,   Method: Compositional matrix adjust.
 Identities = 74/240 (30%), Positives = 112/240 (46%), Gaps = 22/240 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHV---FTAHRLDRPTS 58
           L ILY D+ ++ +NKP+G +VH +  + D  ++          +H+      HRLD+ TS
Sbjct: 86  LNILYADDDIIVINKPAGLVVHPAVGNHDNTLLNALLYHFPQTKHLPRSGIVHRLDKDTS 145

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           G +++  S+ A   L +Q +   + + Y A+V G++     +D P+            R 
Sbjct: 146 GAMVIAHSARAHTDLVRQLQNRSMGRIYLALVYGYITAGDTIDLPIGRHAKDRLKMAVRP 205

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
           D   +PA+THYR            R+ T     V+LE  TGR HQ+R HL+H RHP++GD
Sbjct: 206 DG--KPAITHYR---------IEERWQTLTLLRVQLE--TGRTHQIRVHLSHHRHPLVGD 252

Query: 179 SKHGDLRQNRSGAEHFGLQ------RLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALS 232
             +G      S       Q      R  LHA +L L HP T E +   A L D   Q  +
Sbjct: 253 KLYGARPFLASSLTELQRQALAEFPRQALHAVELHLHHPATNEIMRFTAPLPDDMTQLFT 312


>UniRef50_A4ANB8 Pseudouridine synthase n=3 Tax=Flavobacteriales RepID=A4ANB8_9FLAO
          Length = 308

 Score = 95.5 bits (236), Expect = 2e-18,   Method: Compositional matrix adjust.
 Identities = 75/227 (33%), Positives = 107/227 (47%), Gaps = 40/227 (17%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFT--AHRLDRPTSG 59
           L++LY+DE L A++KPSG LV  +        +        +         HRLD  T+G
Sbjct: 104 LKMLYEDEHLAAIHKPSGILVSGNSFKTITHALSQNLEPSNLPDSTLPQPVHRLDYATTG 163

Query: 60  VLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARED 119
           +LL+G +S   R L   FE+ +I+K Y+AI  G +           E   KI +K A+  
Sbjct: 164 ILLIGKTSSVIRALNGMFERKEIKKTYYAITMGKMEIRG-------EVTLKIDNKNAQSK 216

Query: 120 KGPQPAVTHYRGLATVEMPVATGRYPTTRYG---LVELEPKTGRKHQLRRHLAHLRHPII 176
                          VE  V     P+ R+G   LV+L P TGR+HQLR H++ + +PI+
Sbjct: 217 -------------YVVEETV-----PSERFGQLNLVKLTPITGRRHQLRIHMSGIGNPIL 258

Query: 177 GDSKHG--DLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHA 221
           GDS +G  DL     G        L LHA  +   HP+T E L I +
Sbjct: 259 GDSDYGTKDLILKGKG--------LYLHAYSIEFNHPYTNEKLLIKS 297


>UniRef50_C1ZB48 Pseudouridine synthase, RluA family n=1 Tax=Planctomyces
           limnophilus DSM 3776 RepID=C1ZB48_PLALI
          Length = 325

 Score = 95.1 bits (235), Expect = 2e-18,   Method: Compositional matrix adjust.
 Identities = 79/245 (32%), Positives = 118/245 (48%), Gaps = 24/245 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV-VMQTVRDQIGQHVF-----TAHRLDR 55
           LEIL++D+ L+ +NKP+G + H +    D  ++  +Q   D+   H         HRLDR
Sbjct: 82  LEILFEDDSLLVINKPAGLIAHPTGEIPDGTLINAVQHYLDKQSTHPGLERPGIVHRLDR 141

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEA-VLDYPLVEELDKIADK 114
            TSG + +     + RLL+ QF+  +I K Y A+V G L ++  V+D P +      +  
Sbjct: 142 DTSGAMAICKEHLSHRLLSIQFQLGRISKSYLALVEGVLTDDQLVIDLP-IGRAPGCSSA 200

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
                     A      L  VE      R+P  ++ LVE +P+TGR HQ+R HLA +  P
Sbjct: 201 LMSCRADALEAQASKTSLRVVE------RFP--QHTLVEAKPRTGRMHQIRIHLATIGFP 252

Query: 175 IIGDS---KHGDLR-----QNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDT 226
           I+GD    K G++R     ++        + R  LHA+ LS  HP T E     A L D 
Sbjct: 253 IVGDEFYLKGGEIRPLVWPESERVQVSLLINRQALHAACLSFAHPLTNEWQDFQAPLPDD 312

Query: 227 WMQAL 231
             QA+
Sbjct: 313 LRQAI 317


>UniRef50_A9IQ66 Pseudouridine synthase n=5 Tax=Bacteria RepID=A9IQ66_BART1
          Length = 334

 Score = 95.1 bits (235), Expect = 2e-18,   Method: Compositional matrix adjust.
 Identities = 71/257 (27%), Positives = 123/257 (47%), Gaps = 31/257 (12%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHR---SWLDRDEKVVVMQTVRDQIG----QHVFTAHRLD 54
           L+ILY+D+ ++ +NKP+G +VH    +W       ++        G    +     HRLD
Sbjct: 81  LDILYEDDHVIVINKPAGLVVHPGNGNWTGTLVNALIYHCGNSLSGIGGVKRPGVVHRLD 140

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQH----QIQKRYHAIVRG------WLMEEAVLDYPL 104
           + TSGV+++  +  A + L+ QF  H     + +RYHA++ G      W ++ ++   P 
Sbjct: 141 KNTSGVMVVAKNDLAHKSLSAQFSDHGRTCALDRRYHALIWGTPHRNVWTIDASLGRSPH 200

Query: 105 VEELDKIADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQL 164
                 +  K   +    + AVTH+  L        T    T+   L+E   +TGR HQ+
Sbjct: 201 NRTKQAVVHK---QTPHARHAVTHFSLLEKY----GTHADSTSFASLLECRLETGRTHQI 253

Query: 165 RRHLAHLRHPIIGDSKHGDLRQNRSGAEHFGLQ-------RLMLHASQLSLTHPFTGEPL 217
           R H+AH+ HP+IGD+ +G+  + +S   +  L+       R  LHA+ L+  HP +G+ +
Sbjct: 254 RVHMAHIGHPLIGDTVYGNAFKTKSNTLNPTLKNAIDQFNRHALHAASLTFEHPSSGKVI 313

Query: 218 TIHAGLDDTWMQALSQF 234
           +  A L     Q +   
Sbjct: 314 SFSAPLPQDMAQLIKHL 330


>UniRef50_B6AN83 Pseudouridine synthase n=2 Tax=Leptospirillum RepID=B6AN83_9BACT
          Length = 340

 Score = 95.1 bits (235), Expect = 2e-18,   Method: Compositional matrix adjust.
 Identities = 74/252 (29%), Positives = 117/252 (46%), Gaps = 36/252 (14%)

Query: 2   LEILYQDEWLVAVNKPSGWLVH------------------RSWLDRDEKVVVMQTVRDQI 43
           LEILY+D+ L+ ++KP G +VH                  +S  D  +K    +    + 
Sbjct: 95  LEILYEDDDLIVISKPPGLVVHPAPGHASGTLVNGLLFHFQSQGDEQKKGEPEEEEEAER 154

Query: 44  GQHVFTAHRLDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDY 102
                  HRLD+ TSGV+++G S      L  QF+   + K+Y A+V+G L ++   ++ 
Sbjct: 155 PLRAGLVHRLDQDTSGVMVVGKSETVVLDLMNQFKDRSVSKKYLALVKGILPKKRGEINA 214

Query: 103 PLVEELDKIADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKH 162
           P+         KFA    G +P++T YR L T              Y L+E+   TGR H
Sbjct: 215 PIGRSTHD-RKKFAVRQDG-KPSLTRYRVLETYH----------ENYSLLEVTLLTGRTH 262

Query: 163 QLRRHLAHLRHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAG 222
           Q+R H  HL  P++GD+ +G       G E+    R MLHA +L+  HP +   +   A 
Sbjct: 263 QIRVHFRHLGFPLLGDAVYGS-----KGMENRNFPRQMLHAWKLAFQHPRSAAKMEFEAP 317

Query: 223 LDDTWMQALSQF 234
           L   ++ A+ + 
Sbjct: 318 LPPDFVSAMKRL 329


>UniRef50_D1ANU4 Pseudouridine synthase n=14 Tax=Fusobacteriaceae RepID=D1ANU4_SEBTE
          Length = 305

 Score = 95.1 bits (235), Expect = 2e-18,   Method: Compositional matrix adjust.
 Identities = 71/241 (29%), Positives = 122/241 (50%), Gaps = 25/241 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIGQH----VFTAHRLDR 55
           ++ILY+D  +  ++K +G +VH S       +V  VM  ++D  G +        HRLD+
Sbjct: 77  IKILYEDSDIAVIDKEAGIVVHPSHGHESGTLVNAVMYHIKDLSGINGEIRPGIVHRLDK 136

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKF 115
            TSG+L++  +  A   L++ F    I+K Y AI++G + +E+     L+    K   K 
Sbjct: 137 DTSGLLIIAKNDTAHLRLSEMFGSSGIRKTYIAILKGKINKESGKLETLIGRDPKDRKKM 196

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
           A      + A+T+++ L   E           ++ LV++  +TGR HQ+R H+ +L +P+
Sbjct: 197 AVVKTNGKTAITYFQVLDKNE-----------KFSLVKVNIQTGRTHQIRVHMKYLGYPV 245

Query: 176 IGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFG 235
           +GDS +G  R N+         R MLHA +L   HP T + + I + L   + +AL + G
Sbjct: 246 LGDSVYG--RDNKIAG------RQMLHAYKLEFLHPVTQKAMKIISELPQDFEKALKETG 297

Query: 236 W 236
            
Sbjct: 298 L 298


>UniRef50_A4CLQ5 Pseudouridine synthase n=16 Tax=Bacteria RepID=A4CLQ5_9FLAO
          Length = 236

 Score = 94.7 bits (234), Expect = 2e-18,   Method: Compositional matrix adjust.
 Identities = 80/244 (32%), Positives = 121/244 (49%), Gaps = 32/244 (13%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQH------VF--TAHRL 53
           L +LY+D  L+AV+K +G +V     D+     + +TV+D I         VF    HRL
Sbjct: 11  LMVLYEDNHLIAVSKRAGDIVQG---DKTGDTPLPETVKDYIAHKYQKPGKVFLGVVHRL 67

Query: 54  DRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIAD 113
           DRPT+GV++   +S+A   + + F +   +K Y A+V     E A      +E   K   
Sbjct: 68  DRPTTGVIVFARTSKALSRMNRLFAEGGTRKTYWALVGTPPPETAGRLVHWLERNQKQNK 127

Query: 114 KFAR--EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHL 171
            +AR  E  G + A+ +YR L +++           RY L+E++ +TGR HQ+R  LA +
Sbjct: 128 SYARAKEVPGSKQAILNYRLLGSLD-----------RYHLLEIDLETGRHHQIRAQLAAI 176

Query: 172 RHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGL-DDTWMQA 230
             PI GD K+G  R N  G  H       LHA +L   HP   +P++I A L DD   +A
Sbjct: 177 GSPIKGDLKYGFPRSNPDGGIH-------LHARRLEFIHPVRQDPVSILAPLPDDPLWEA 229

Query: 231 LSQF 234
             + 
Sbjct: 230 CGKL 233


>UniRef50_B7HGW1 Pseudouridine synthase n=52 Tax=Bacillales RepID=B7HGW1_BACC4
          Length = 297

 Score = 94.7 bits (234), Expect = 3e-18,   Method: Compositional matrix adjust.
 Identities = 75/243 (30%), Positives = 121/243 (49%), Gaps = 43/243 (17%)

Query: 2   LEILYQDEWLVAVNK------------PSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFT 49
           L I+Y+D+ ++ +NK            P+G  V  + L   +K  +  TV      H+ T
Sbjct: 82  LCIIYEDDAVLIINKEANMSTIPSREHPAGS-VANALLSHYDKQHLASTV------HIVT 134

Query: 50  AHRLDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEEL 108
             RLDR TSG++L+  +     LL++Q +Q  +++ Y AIV G ++E E ++D P+  + 
Sbjct: 135 --RLDRDTSGLMLIAKNRFVHHLLSKQHQQKAVKRTYEAIVHGKIVEREGMIDAPIGRKS 192

Query: 109 DKIADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHL 168
           D I ++   ED   Q AVTH++        V    Y  T    V LE +TGR HQ+R H+
Sbjct: 193 DSIIERTVCED--GQRAVTHFK--------VIDSTYHKTH---VALELETGRTHQIRVHM 239

Query: 169 AHLRHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWM 228
           AH+ HP++GDS +G  R          ++R  LH+  L+  HP   + ++    L     
Sbjct: 240 AHVGHPLLGDSLYGGRRDE--------MKRQALHSKSLTFYHPILEKEMSFTIKLPSDMQ 291

Query: 229 QAL 231
           + L
Sbjct: 292 EVL 294


>UniRef50_C4GB89 Pseudouridine synthase n=1 Tax=Shuttleworthia satelles DSM 14600
           RepID=C4GB89_9FIRM
          Length = 337

 Score = 94.7 bits (234), Expect = 3e-18,   Method: Compositional matrix adjust.
 Identities = 68/218 (31%), Positives = 115/218 (52%), Gaps = 24/218 (11%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSW---LDRDEKVVVMQTVRDQIGQ------HVFTAHRLD 54
           ++Y+DE ++A++KP+G L  R+    +  +E+++     +  + +      H   A+RLD
Sbjct: 94  VIYEDEDILALDKPAGCLSQRAGQKDISLNEEMLAYLIAKGALTRESYFLFHPSVANRLD 153

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDK---- 110
           R TSG++L G +    + L++Q     + K YH IVRG L EE  LD  L +++ +    
Sbjct: 154 RNTSGLILAGKTLRGQQYLSEQLRDRSVIKLYHTIVRGRLTEELQLDGYLYKDVGRNQVL 213

Query: 111 IADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAH 170
           +++K     +G Q   T YR       P+   +  T    L+E+   TGR HQ+R HLA 
Sbjct: 214 VSEKKEDLPEGAQEIHTAYR-------PLDHRKDLT----LLEVHLMTGRSHQIRAHLAS 262

Query: 171 LRHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSL 208
           + HPI GD K+GD   N+     +G++  +LH+  + L
Sbjct: 263 IGHPIAGDPKYGDFHWNQILRRKYGVRGQLLHSYSIKL 300


>UniRef50_D1B0V0 Pseudouridine synthase n=1 Tax=Sulfurospirillum deleyianum DSM 6946
           RepID=D1B0V0_SULD5
          Length = 302

 Score = 94.7 bits (234), Expect = 3e-18,   Method: Compositional matrix adjust.
 Identities = 72/233 (30%), Positives = 118/233 (50%), Gaps = 27/233 (11%)

Query: 5   LYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLMG 64
           +++ E     +KPSG ++H     R +   +   ++   G+    AHR+D+ TSG++L+G
Sbjct: 73  IFETEDFAVFDKPSGVMIHPR--KRSDGYTLNDEIKSLYGKDANAAHRIDKSTSGLVLVG 130

Query: 65  LSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELD--KIADKFAREDKGP 122
              ++   L + F   ++QK Y A+V+G L EE ++D  L  +++  +I  K   +++G 
Sbjct: 131 KHKQSEIALKEIFATRKVQKSYIALVKGHLKEELLIDEKLKRDVETSQIRLKVHVDERG- 189

Query: 123 QPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHG 182
           +P+ T    L   E   AT         LV+  P TGR+HQ+R HL H++HPI+GD  +G
Sbjct: 190 KPSQTKVIPLHYFEDKDAT---------LVQAFPYTGRQHQIRVHLFHVKHPIVGDMIYG 240

Query: 183 ----DLRQNRSGA-------EHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLD 224
               D  +   G+       E     RL+LHA  LS    F G   TI + +D
Sbjct: 241 VEEEDAERYLDGSMSAEEQYEKTLSSRLLLHAYSLSFN--FKGVDYTIESTID 291


>UniRef50_A1HR26 Pseudouridine synthase, RluA family n=1 Tax=Thermosinus
           carboxydivorans Nor1 RepID=A1HR26_9FIRM
          Length = 301

 Score = 94.7 bits (234), Expect = 3e-18,   Method: Compositional matrix adjust.
 Identities = 78/229 (34%), Positives = 117/229 (51%), Gaps = 32/229 (13%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV---VMQTVRDQIGQHVF-TAHRLDRPT 57
           L I+Y+D++L+ VNKP+G LVH +  D  E  +   ++  +  +     F   HRLDR T
Sbjct: 75  LHIVYEDDFLLIVNKPAGLLVHPTS-DPTEPTLAHGILYYLHSKGALGAFHPIHRLDRNT 133

Query: 58  SGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGW---LMEEAVLDYPLVEELDKIADK 114
           SG++ +         L+    +  +++ Y A+V G    LM    +D P+    + I  +
Sbjct: 134 SGLVAIAKHPHIQHALSGGGAK-GLKRLYLAVVTGIPSSLMGR--IDAPIGRHPNSIIKR 190

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
             R D   QPA+T YR L+T  M             LVELE  TGR HQ+R HL+H+ HP
Sbjct: 191 VVRSDG--QPAITLYRVLSTFSM-----------ASLVELELLTGRTHQIRVHLSHIGHP 237

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGL 223
           ++GD  +G       GA    ++R  LHA+ LS  HP T + LT+ + L
Sbjct: 238 LLGDDLYG-------GATDL-IRRQALHAASLSFRHPATDKVLTLTSPL 278


>UniRef50_Q0BWH2 Pseudouridine synthase n=3 Tax=Alphaproteobacteria
           RepID=Q0BWH2_HYPNA
          Length = 341

 Score = 94.7 bits (234), Expect = 3e-18,   Method: Compositional matrix adjust.
 Identities = 78/252 (30%), Positives = 114/252 (45%), Gaps = 34/252 (13%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIG-----QHVFTAHRLD 54
           LEIL++D  LV +NK +G  VH +   +   +V  ++   + Q+      +     HRLD
Sbjct: 81  LEILFEDAHLVILNKAAGMAVHPAPGSQTGTLVNALLHHCQGQLSGIGGVERPGIVHRLD 140

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGW------LMEEAVLDYPLVEEL 108
           + TSGV++   +  A   LA  FE+H I + Y A+ RG        +E A+       E 
Sbjct: 141 KLTSGVMVAAKTESAHTGLAALFERHDIDRVYRAVTRGAPRPLSGTIEAAIAR----SES 196

Query: 109 DKIADKFAREDKGPQP--AVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRR 166
           D+      R    P    AVTHY+ + T        R P     L+E   +TGR HQ+R 
Sbjct: 197 DRKKMSVHRNPDSPAARHAVTHYKAVETFGYKDRATRLPAA--ALLECRLETGRTHQIRV 254

Query: 167 HLAHLRHPIIGDSKHG-------------DLRQNRSGAEHFGLQRLMLHASQLSLTHPFT 213
           H+AH   P+IGD  +G             + R +++ A      R  LHA+ L   HP T
Sbjct: 255 HMAHSGAPLIGDPVYGRQAGIMAWKAPGSEARYDKALAAARAFSRQALHAAVLGFVHPIT 314

Query: 214 GEPLTIHAGLDD 225
           GE L   A L +
Sbjct: 315 GETLRYEAPLPE 326


>UniRef50_Q0BUM2 Pseudouridine synthase n=12 Tax=Acetobacteraceae RepID=Q0BUM2_GRABC
          Length = 366

 Score = 94.4 bits (233), Expect = 3e-18,   Method: Compositional matrix adjust.
 Identities = 85/267 (31%), Positives = 124/267 (46%), Gaps = 38/267 (14%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLM 63
           ILY+D+ L+ +NKPSG               ++  +R          HRLDR TSGV+++
Sbjct: 125 ILYKDDHLIVLNKPSGLPSQGGPGITRHLDGLLDGLRFGRDDRPRLVHRLDRDTSGVIVI 184

Query: 64  GLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDK-----IADKFAR 117
             S      LA  F   + +K Y A+V G  +  E  +D PL+ + D+     +AD   R
Sbjct: 185 ARSPGVAAKLAALFRTRETEKVYWAVVAGRPVPVEGRIDRPLLRQNDRNEPVVLAD---R 241

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
           +D+    A+T YR L           +   +   +EL P TGR HQLR H A +  PI+G
Sbjct: 242 KDRDKVTAITDYRTLD----------HAARKLAWLELRPLTGRMHQLRVHCAAMDAPILG 291

Query: 178 DSKHG-----DLRQNRSGAEHFGL-QRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
           D ++G     D R  R+ A   GL +RL LHA +LSL HP  G  L++ A L     +  
Sbjct: 292 DERYGSWRNTDERGVRNTALVEGLSRRLHLHARRLSLPHPAGGM-LSVEADLSPHMAETF 350

Query: 232 SQFGWRGLLPENERVEFSAPSGQDGEI 258
              G            F+AP  ++G +
Sbjct: 351 ETLG------------FTAPKAREGRL 365


>UniRef50_C5BU65 Pseudouridine synthase for 23S rRNA and tRNAphe n=1
           Tax=Teredinibacter turnerae T7901 RepID=C5BU65_TERTT
          Length = 208

 Score = 94.4 bits (233), Expect = 3e-18,   Method: Compositional matrix adjust.
 Identities = 76/225 (33%), Positives = 108/225 (48%), Gaps = 23/225 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           L I+YQD+ ++A+NKP+G L        D      Q V       V   HRLD  TSG++
Sbjct: 4   LAIIYQDDHIIAINKPAGLLTVPGLATPDN--AFDQLVHQHPNSRV--VHRLDMATSGLV 59

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADKFAREDK 120
           +   S E+     + FEQ ++ K Y A V G + E+   +  PL+ +      +    ++
Sbjct: 60  IFPQSHESLVRFGRLFEQRKMTKTYTATVAGIVAEDRGEITLPLICDWPNRPKQKVDLEQ 119

Query: 121 GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSK 180
           G   A T Y+ L    + + T R        +EL P TGR HQLR H+  L HPI+GD+ 
Sbjct: 120 GKH-AHTQYKVLER-RLDLQTTR--------IELTPITGRSHQLRVHMQQLGHPILGDAF 169

Query: 181 HG-DLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLD 224
           +  D  Q  S        RL+LHA+ L   HPFT  P +IH   D
Sbjct: 170 YAPDAIQQASD-------RLLLHATTLEFVHPFTQCPTSIHCEPD 207


>UniRef50_Q5E092 Pseudouridine synthase n=3 Tax=Aliivibrio RepID=Q5E092_VIBF1
          Length = 576

 Score = 94.4 bits (233), Expect = 4e-18,   Method: Compositional matrix adjust.
 Identities = 70/228 (30%), Positives = 108/228 (47%), Gaps = 30/228 (13%)

Query: 2   LEILYQDEWLVAVNKPSGWL-VHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGV 60
           LEI+Y+D+ LV VNKP  +L V   ++       +     +  G  +   HRLD  TSG+
Sbjct: 373 LEIVYEDDVLVIVNKPVEFLSVSGKYISDSVHARIQARYPNATGPLI--VHRLDMSTSGL 430

Query: 61  LLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADKFARED 119
           L++ L++E+ + + +QF +  ++KRY A++ G +  +   ++ PL  +++    +     
Sbjct: 431 LVLTLTAESNKQVQKQFIERTVEKRYTALLEGNIETDNGTINLPLTGDMEDRPRQMVNHK 490

Query: 120 KGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAH---LRHPII 176
            G + A THY+ +A              +   V L P TGR HQLR H AH   L  PI+
Sbjct: 491 SG-RKAETHYQVIAQ-----------EGKRTKVHLYPHTGRTHQLRVHCAHQAGLNTPIV 538

Query: 177 GDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLD 224
           GD  +G           F   RL LHA  L   HP T E +      D
Sbjct: 539 GDDLYG-----------FKADRLHLHAGYLKFKHPTTNETVEFSCPED 575


>UniRef50_C0M8E2 Pseudouridine synthase n=3 Tax=Streptococcus equi
           RepID=C0M8E2_STRE4
          Length = 301

 Score = 94.4 bits (233), Expect = 4e-18,   Method: Compositional matrix adjust.
 Identities = 70/221 (31%), Positives = 104/221 (47%), Gaps = 24/221 (10%)

Query: 1   MLEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGV 60
           +++ LYQDE L+ VNKP G   H    +   ++ ++  V    G+  +  HRLD  TSG 
Sbjct: 92  LVDCLYQDEHLIIVNKPEGMKTHG---NEPTELALLNHVSAYTGKTCYVVHRLDMETSGA 148

Query: 61  LLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDK 120
           +L   +     +L +  E   I++ Y A++ G L ++ V     +        K   + K
Sbjct: 149 ILFAKNPFILPILNRLLEHRDIKRDYWALIEGQLEQQTVTYRDPIGRHRHDRRKRVVDSK 208

Query: 121 GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSK 180
             Q A+TH   L   +              LV    +TGR HQ+R HLAH +HP+IGD  
Sbjct: 209 HGQEAITHLALLQAFDQTC-----------LVNCRLETGRTHQIRVHLAHHKHPLIGDPL 257

Query: 181 HGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHA 221
           +     +R  AE     RLMLHA QL+L HP   E + + A
Sbjct: 258 Y-----SRQKAE-----RLMLHAHQLTLRHPLAQEMIRVTA 288


>UniRef50_A5WCP4 Pseudouridine synthase n=15 Tax=Moraxellaceae RepID=A5WCP4_PSYWF
          Length = 364

 Score = 94.4 bits (233), Expect = 4e-18,   Method: Compositional matrix adjust.
 Identities = 71/214 (33%), Positives = 114/214 (53%), Gaps = 30/214 (14%)

Query: 4   ILYQDEWLVAVNKPSGWLVHR-SWLDRDEKVVVMQTVRDQIGQ-HVFTAHRLDRPTSGVL 61
           ++Y+DE L+ +NKPSG  VH  S LD      V++ +RD   + ++   HR+D+ TSG+L
Sbjct: 147 VVYEDEGLIVLNKPSGMAVHGGSGLD----FGVIEAMRDATSKKYLELVHRIDKDTSGLL 202

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGW-LMEEAVLDYPLVEELDKIADKFAREDK 120
           ++       ++L +   +  IQK Y  +V+G   + E  +D PL+       ++  + DK
Sbjct: 203 MIAKKRSTLKVLQEYLREKTIQKHYLCLVKGQPALNEFEIDAPLLRYTVANGERRVKVDK 262

Query: 121 G-PQPAV--THYRGLATVEM---PVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
             P+  +  T  + LA  +M   PV+          L+E  P TGR HQ+R HLA+L HP
Sbjct: 263 ANPEAKLSQTTCKVLARFKMNGEPVS----------LIEAMPHTGRTHQIRVHLAYLGHP 312

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSL 208
           I+GD K+       +  +  G++RL LHA QL +
Sbjct: 313 ILGDDKY-------NIKDTSGVRRLCLHAWQLDV 339


>UniRef50_Q3AD19 Ribosomal large subunit pseudouridine synthase, RluA family n=1
           Tax=Carboxydothermus hydrogenoformans Z-2901
           RepID=Q3AD19_CARHZ
          Length = 301

 Score = 94.0 bits (232), Expect = 4e-18,   Method: Compositional matrix adjust.
 Identities = 68/238 (28%), Positives = 121/238 (50%), Gaps = 32/238 (13%)

Query: 2   LEILYQDEWLVAVNKPSGWLVH--RSWLDRDEKVVVMQTVRDQ--IGQHVFTAHRLDRPT 57
           +++LY+D++L+ ++KP+G L H  ++      + + +   RD+  I +  +  +RLDR T
Sbjct: 77  VKVLYEDDYLIVIDKPAGVLAHPVKNHFAPSMQELTLSYYRDKGRIFEGFYPIYRLDRNT 136

Query: 58  SGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEA-VLDYPLVEELDKIADKFA 116
           SG +L+   S    +L     + QI K Y A++ G L +++ +++ PL      I  +  
Sbjct: 137 SGPMLIAKFSLIAEMLNNSLRKRQINKIYLALIEGPLADKSGIINLPLGLLEGSIIKRAV 196

Query: 117 REDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPII 176
               G QPA T Y+ +           +PT  + L+++E  TGR HQ+R H A + HP+ 
Sbjct: 197 VP--GGQPACTKYQTVKA---------FPT--HTLLKVELLTGRTHQIRAHFAAIGHPLA 243

Query: 177 GDSKHG---DLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
           GD  +G   DL           ++R  LH   +S  HP T + ++++A L   + +AL
Sbjct: 244 GDDLYGGKMDL-----------IERQALHLYYISFPHPITKKTISLYAPLPRDFKEAL 290


>UniRef50_Q1CZL9 Pseudouridine synthase n=5 Tax=Proteobacteria RepID=Q1CZL9_MYXXD
          Length = 559

 Score = 93.6 bits (231), Expect = 5e-18,   Method: Compositional matrix adjust.
 Identities = 80/223 (35%), Positives = 107/223 (47%), Gaps = 28/223 (12%)

Query: 2   LEILYQDEWLVAVNKPSGWL-VHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGV 60
           L+I+++DEWLV V KP G L V    +  ++ V+     R         AHRLD  TSG+
Sbjct: 354 LDIVFEDEWLVVVEKPEGLLSVPAKDVSVEDSVLARLRARAPEAAGTMLAHRLDLDTSGL 413

Query: 61  LLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADKFARED 119
           L+    +     L +QF   ++ KRY A V G +  E   +D+P+  +LD    +     
Sbjct: 414 LVAAKDARTYAALQRQFAGREVHKRYAAWVEGNVQGERGTIDFPMRVDLDDRPRQIHDPV 473

Query: 120 KGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAH---LRHPII 176
            G +PAVT +  L       + GR        V L P TGR HQLR H AH   L  PI+
Sbjct: 474 HG-KPAVTEWHVLER-----SHGRT------KVALFPLTGRTHQLRVHAAHPLGLGAPIV 521

Query: 177 GDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTI 219
           GD  +G          H G  RL LHA  LS  HP TG+ LT+
Sbjct: 522 GDRLYG----------HPG-PRLHLHAEALSFQHPVTGQRLTL 553


>UniRef50_B7GQ28 Pseudouridine synthase, RluA family n=21 Tax=Bifidobacteriaceae
           RepID=B7GQ28_BIFLI
          Length = 320

 Score = 93.6 bits (231), Expect = 6e-18,   Method: Compositional matrix adjust.
 Identities = 74/229 (32%), Positives = 118/229 (51%), Gaps = 42/229 (18%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRS--WLDRDEKVVVMQTVRDQIGQHVFT---------A 50
           + ++Y+D+ ++ V+KP G   H S  W        V+ ++RD+ G H+ +          
Sbjct: 77  MAVVYEDDDVIVVDKPVGVAAHASVGWTGP----TVLGSLRDR-GVHIASYGAAGREGIV 131

Query: 51  HRLDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELD 109
            RLD  TSG++L+  S  A   + +QF +H+++K YHA+V+G L E +A ++ P+     
Sbjct: 132 SRLDVGTSGLMLVCKSDLAYTEMRRQFAEHEVKKTYHALVQGGLKENKATIEAPIGRA-- 189

Query: 110 KIAD-KFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYG----LVELEPKTGRKHQL 164
           K++D +F     G +PAVTH+  L               R+G    LV +  +TGR HQ+
Sbjct: 190 KVSDFRFCVTPAG-KPAVTHWDVL--------------ERFGHEATLVSVNLETGRTHQI 234

Query: 165 RRHLAHLRHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFT 213
           R H + + HP+ GD  +G    N   +E  GL R  LHA +L   HP T
Sbjct: 235 RVHFSSIGHPLCGDPMYG---ANPVLSEALGLDRQWLHAMKLEFRHPRT 280


>UniRef50_C4XSN0 Ribosomal large subunit pseudouridine synthase D/dephospho-CoA
           kinase n=1 Tax=Desulfovibrio magneticus RS-1
           RepID=C4XSN0_DESMR
          Length = 554

 Score = 93.6 bits (231), Expect = 6e-18,   Method: Compositional matrix adjust.
 Identities = 72/228 (31%), Positives = 114/228 (50%), Gaps = 20/228 (8%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVV-----MQTVRDQIGQHVFTAHRLDRP 56
           L++LY D  ++ +NKP+G  +H +    D  +V         +R   G      HRLD+ 
Sbjct: 93  LKLLYLDGDVLVLNKPAGLTIHPASSQPDGTLVNRLLHHFPDMRAMAGDRPGIVHRLDKD 152

Query: 57  TSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADKF 115
           TSG+LL+  +  A   LA  F + ++ K Y A+V G     + V++ P+  +  K   K 
Sbjct: 153 TSGLLLVAQTESARLALAADFAERRVAKTYLALVHGRPERSDGVIELPVGRD-PKHPTKM 211

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
           A   KG + A + ++   T          P     L+E+   TGR HQ+R H+A + HPI
Sbjct: 212 AVVAKGGREAKSSWKLAWTA---------PDGTASLLEVAIATGRTHQIRVHMAAMGHPI 262

Query: 176 IGDSKHGDLRQN----RSGAEHFGLQRLMLHASQLSLTHPFTGEPLTI 219
           +GD+ +G  + +    R GA     +R MLHA +L+ +HP TGE L+ 
Sbjct: 263 VGDAVYGARQHSDWTRRGGAMARLAKRQMLHAWKLAFSHPGTGEELSF 310


>UniRef50_Q82WZ5 Ribosomal large subunit pseudouridine synthase D n=2
           Tax=Nitrosomonas RepID=RLUD_NITEU
          Length = 344

 Score = 93.6 bits (231), Expect = 6e-18,   Method: Compositional matrix adjust.
 Identities = 76/236 (32%), Positives = 118/236 (50%), Gaps = 18/236 (7%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHR---SWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTS 58
           L+IL++D+ L+ ++KP+G +VH    +W       ++    +          HRLD+ T+
Sbjct: 109 LKILFEDDHLIIIDKPAGLVVHPGNGNWHGTLLNALLNHAPQLSQVPRAGIVHRLDKDTT 168

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           G+L++  + EA   LA+Q +Q  +++ Y A+V G L ++ V+D P+      I       
Sbjct: 169 GLLVVAKTIEAQFDLARQLQQRTVKRHYLALVLGKLEKDGVVDAPIGRH--PIHRTRMAV 226

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
            +  +PA THYR L              T   L+    +TGR HQ+R HL  + HP+ GD
Sbjct: 227 VQNGKPARTHYRVLEKF-----------TASTLLHCSLETGRTHQIRVHLLSIGHPLAGD 275

Query: 179 SKHGDLRQNRSGAEH-FGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
             +G    + S A+    L R  LHA QL LTHP +G+ L   + L D  M AL Q
Sbjct: 276 PVYGRTSPDPSTADAVVRLPRQALHAWQLELTHPHSGQILLWESPLPDD-MAALLQ 330


>UniRef50_Q6AIJ2 Probable ribosomal large subunit pseudouridine synthase A n=1
           Tax=Desulfotalea psychrophila RepID=Q6AIJ2_DESPS
          Length = 211

 Score = 93.6 bits (231), Expect = 6e-18,   Method: Compositional matrix adjust.
 Identities = 81/223 (36%), Positives = 109/223 (48%), Gaps = 30/223 (13%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV---VMQTVRDQIGQHVFTAHRLDRPTS 58
           L+I+Y+D+ LV V KP G L        +   V   +   + + I Q     HRLD  TS
Sbjct: 4   LKIIYRDDHLVVVIKPGGLLSVPGRGPENSDCVSSRLQAKIPEMITQP--AVHRLDMYTS 61

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADKFAR 117
           G+++  +S E  R L+ QF++ Q+ K+Y A++ G L E    +  P   +LD    +   
Sbjct: 62  GLMVYAVSKEIHRALSIQFQEQQVDKKYTALLEGCLQEVSGEIRLPFRVDLDNRPIQILD 121

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAH---LRHP 174
              G +  +T +R     +M    G    TR   VE  P TGR HQLR H AH   L  P
Sbjct: 122 YQHG-KMGITLWR-----KMDEKNG---ITR---VEFTPMTGRTHQLRVHAAHAKGLGIP 169

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPL 217
           IIGDS +G     R G E      +MLHA QLS THP  GE L
Sbjct: 170 IIGDSFYG---SGRDGDE------MMLHAHQLSFTHPIIGEKL 203


>UniRef50_A8U9H8 Pseudouridine synthase n=2 Tax=Bacilli RepID=A8U9H8_9LACT
          Length = 309

 Score = 93.2 bits (230), Expect = 7e-18,   Method: Compositional matrix adjust.
 Identities = 61/230 (26%), Positives = 116/230 (50%), Gaps = 22/230 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRD---EKVVVMQTVRDQIGQHVFTAHRLDRPTS 58
           + ILY+D+ ++ ++K +G L   +   ++    + ++    ++     ++  HRLDR TS
Sbjct: 95  MTILYEDDAIIVIDKEAGLLSIAAKFAQELTAHRQLINYVKQENQNNRIYVVHRLDRDTS 154

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           GV++   + +  + + + +++   ++ Y A+V G + E+       + E   +    A  
Sbjct: 155 GVMVFAKTEKIKQDMQENWKEIVKERIYTALVEGVVREDEGTIKTWLTESKAMKVHSATY 214

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
           D G + A+THY+ +   E            + L+E   +TGRK+Q+R H+  L HP+ GD
Sbjct: 215 DNGGKLAITHYKKIRNNE-----------DFTLLEARLETGRKNQIRVHMETLGHPVAGD 263

Query: 179 SKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWM 228
            K+        GA    L+RL LHA+ L+L HP TGE +  H+ +   ++
Sbjct: 264 KKY--------GATSNPLKRLGLHATTLALIHPTTGELVRFHSKVPKAFL 305


>UniRef50_B8CWM0 Pseudouridine synthase n=1 Tax=Halothermothrix orenii H 168
           RepID=B8CWM0_HALOH
          Length = 308

 Score = 93.2 bits (230), Expect = 7e-18,   Method: Compositional matrix adjust.
 Identities = 70/237 (29%), Positives = 121/237 (51%), Gaps = 25/237 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV-VMQTVRDQIG-----QHVFTAHRLDR 55
           L+I+Y+D+ ++ +NK +G +VH +  + +  +V  +    D +            HRLD+
Sbjct: 82  LDIIYEDKDILVLNKNAGLVVHPAPGNHENTLVNALIAYCDNLSTISGVNRPGIVHRLDK 141

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADK 114
            TSGV+++  +  + R L +QF+Q + +K Y  +++G L  +E  +D P+  +      K
Sbjct: 142 DTSGVMVIAKNDISHRKLVEQFKQRKTKKYYRTLLKGELPYKEGKIDAPIGRDPHD-RKK 200

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
            A   K  + AVT+++ L                +  VE+E KTGR HQ+R H +++  P
Sbjct: 201 MAVTRKNSKKAVTYFKVLEFFR-----------DHSYVEVELKTGRTHQIRVHFSYMGFP 249

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
           ++GDS +G  R NR  A      R +LHA +L   HP   + +   A L D + +AL
Sbjct: 250 VVGDSIYGKKR-NRLQA-----TRQLLHAYRLGFYHPRNDKWVEYKASLPDDFKKAL 300


>UniRef50_A6CF60 Pseudouridine synthase n=1 Tax=Planctomyces maris DSM 8797
           RepID=A6CF60_9PLAN
          Length = 317

 Score = 93.2 bits (230), Expect = 8e-18,   Method: Compositional matrix adjust.
 Identities = 75/239 (31%), Positives = 108/239 (45%), Gaps = 16/239 (6%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRS--WLDRDEKVVVMQTVRDQIGQHVF----TAHRLDR 55
           LE+LY+D WL+ VNKP G + H +   L       +   +  Q G          HRLD+
Sbjct: 83  LEVLYEDAWLIIVNKPPGMIAHPAGNILSGTVANALQYYLDQQTGVRSLLRPGIVHRLDQ 142

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKF 115
            TSG+L++       R L+ QF+Q+++ K Y AIVR    ++      L E  D I +  
Sbjct: 143 FTSGILIVAKEHLGHRSLSIQFQQNRVSKSYLAIVRDQPKQD------LFENNDAIGEHP 196

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
            +            R  A         R P   + L+   PKTGR HQ+R HLA L  PI
Sbjct: 197 TQAGVCMTTHPEALRAKAAFTRFEVVERLPG--HSLIRAFPKTGRLHQIRVHLADLGFPI 254

Query: 176 IGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           I D  +G+    R   +   + R  LHA Q+  +HP T   + I AG+   +  AL + 
Sbjct: 255 IADDFYGN--DARLLDDRELISRQALHAEQIEFSHPVTSLRMNISAGVPADFQLALQRI 311


>UniRef50_A9CFZ5 Pseudouridine synthase n=3 Tax=Rhizobiales RepID=A9CFZ5_AGRT5
          Length = 222

 Score = 93.2 bits (230), Expect = 8e-18,   Method: Compositional matrix adjust.
 Identities = 74/213 (34%), Positives = 111/213 (52%), Gaps = 24/213 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIGQHVFTAHRLDRPTSG 59
           L I+++D+ L+ ++KPSG L   S   RD  +   +M  V+ Q  + +   +RLD+ TSG
Sbjct: 18  LTIVHRDDDLLVLDKPSGLL---SVPGRDPALSDSLMTRVQKQFPKALMI-NRLDKDTSG 73

Query: 60  VLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADKFARE 118
           ++LM L+ +A   +A QFE+ + +K Y AIV G +  EE  +D PL  + D         
Sbjct: 74  IVLMSLNRKAHAAIAAQFEKRETRKSYVAIVWGTVAGEEGEVDLPLAIDPDNKPRHRVDH 133

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
           + G +PA + +R L  + +       P TR  L    P TGR HQLR H+  L HPI+GD
Sbjct: 134 ENG-KPAQSLWRVLERLPL-------PATRLALT---PLTGRTHQLRVHMKALGHPILGD 182

Query: 179 SKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHP 211
             + +      G       RLMLHA ++   HP
Sbjct: 183 EFYAE------GEALTAAPRLMLHAQEVGFRHP 209


>UniRef50_B8I5R6 Pseudouridine synthase n=2 Tax=Clostridium RepID=B8I5R6_CLOCE
          Length = 303

 Score = 93.2 bits (230), Expect = 8e-18,   Method: Compositional matrix adjust.
 Identities = 63/213 (29%), Positives = 114/213 (53%), Gaps = 25/213 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEK-VVVMQTVRDQIGQHVFTAHRLDRPTSGV 60
             ++Y D+ L+ VNK +G  VH    D+++K   ++  ++   G ++   HRLDR TSG+
Sbjct: 76  FSVVYDDDNLLIVNKETGIPVHP---DKNQKEATLIDKLQSIYGPNLALCHRLDRNTSGL 132

Query: 61  LLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEA--VLDYPLVEELDKIADKFARE 118
           +++  +     ++ ++ +  +IQK Y  IV G + ++   ++DY  +E+ +K++  F   
Sbjct: 133 VIIAKNPATLEVMLEKIKNREIQKYYTCIVSGKMEKKNAELVDY--LEKNEKLSRVFINP 190

Query: 119 DKGPQPA--VTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPII 176
           +K       +T YR LA++               L+E+E  TGR HQ+R HLA+  HPII
Sbjct: 191 EKTRNSVQIITRYRILASM-----------NSLNLLEVELVTGRTHQIRAHLAYYGHPII 239

Query: 177 GDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLT 209
           GD K+G   +N+     +  +  +L AS+L+  
Sbjct: 240 GDGKYGKNAENK----QYNAKYQLLCASRLTFN 268


>UniRef50_B0S0X9 Pseudouridine synthase n=2 Tax=Finegoldia magna RepID=B0S0X9_FINM2
          Length = 321

 Score = 93.2 bits (230), Expect = 8e-18,   Method: Compositional matrix adjust.
 Identities = 62/216 (28%), Positives = 103/216 (47%), Gaps = 26/216 (12%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFT-----------A 50
           L+I+Y+D+ L+ +NK +G L H +      K +V   V   I  + F             
Sbjct: 84  LDIIYEDDDLILINKKTGVLSHAANPQDYGKNIVDMMVSYLIKTNQFKPTQNSTFTPALV 143

Query: 51  HRLDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDK 110
           +RLDR TSG+++   + ++ +     F++H+I K Y  IV G L ++ + D  L ++ DK
Sbjct: 144 NRLDRNTSGIVVGAKTYDSLKYFNDLFKKHEITKIYETIVVGNLKDQTI-DLALEKDNDK 202

Query: 111 IADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAH 170
                    K     V + +                 +Y LV ++  TGR HQ+R HL+H
Sbjct: 203 NKSVINSSGKKSMTKVWNVKNFG--------------KYSLVNVDLLTGRTHQIRAHLSH 248

Query: 171 LRHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQL 206
           + HPIIGD K+G+   N+     + L   +LH+ +L
Sbjct: 249 INHPIIGDIKYGNREVNKYFKNKYDLNFQLLHSYKL 284


>UniRef50_B2UL66 Pseudouridine synthase n=2 Tax=Verrucomicrobiaceae
           RepID=B2UL66_AKKM8
          Length = 323

 Score = 93.2 bits (230), Expect = 8e-18,   Method: Compositional matrix adjust.
 Identities = 76/251 (30%), Positives = 119/251 (47%), Gaps = 25/251 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIG----QHVFTAHRLDR 55
           L+ILY+DE +V +NK SG +VH +  + D  +V  ++    D  G    +     HRLD+
Sbjct: 77  LDILYEDEDVVVINKESGMVVHPAAGNPDGTIVNALLHHCGDLSGIGGVERPGIVHRLDK 136

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEA--VLDYPLVEELDKIAD 113
            TSG L++  +  A + L  QF     +KRY A+V+G   + +  V  +     ++++  
Sbjct: 137 DTSGCLVIAKNDGAHQSLTAQFAARSTEKRYLAVVQGIPSQSSGTVFTHIGRHPVNRLKM 196

Query: 114 KFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
                  G + A+T Y  L            P+T   LV     TGR HQ+R H+ +L H
Sbjct: 197 AVVNPGSG-KAAITDYDLLCA---------DPSTDSSLVLCTLHTGRTHQIRVHMLYLGH 246

Query: 174 PIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           P+IGD  +    + ++        RLMLHA +L   HP TG+ +   A +   +   L  
Sbjct: 247 PLIGDPIYAKPARQKAKP-----GRLMLHAWRLGFDHPRTGKRMDFEAPVPPEYTPWLQL 301

Query: 234 F--GWRGLLPE 242
           F  G  G +PE
Sbjct: 302 FPNGLYGAIPE 312


>UniRef50_D1N7N8 Pseudouridine synthase, RluA family n=1 Tax=Victivallis vadensis
           ATCC BAA-548 RepID=D1N7N8_9BACT
          Length = 323

 Score = 93.2 bits (230), Expect = 8e-18,   Method: Compositional matrix adjust.
 Identities = 73/244 (29%), Positives = 117/244 (47%), Gaps = 20/244 (8%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVR-DQIGQHVFT-------AHRLDR 55
           ILY+D+ ++ ++KP+G +VH +  +    VV     R  Q+ + +          HRLD+
Sbjct: 85  ILYEDDVMLVIDKPAGVVVHPAAGNPTGTVVNALLGRYPQLAEQLACTTSRPGIVHRLDK 144

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKF 115
            TSG L +  ++ A   L+  F   + +K Y AI RG  +  +     L+        K 
Sbjct: 145 DTSGCLAVAKTANAQFKLSTAFAGRETRKTYLAITRGVPIRRSGELSTLIGRHPVSRQKM 204

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
           A  ++  + A+T YR    VE    TG       G++ +   TGR HQ+R HLA L  P+
Sbjct: 205 AVVERNGKLAITRYR----VEY---TGMLDGVEIGVLAVRILTGRTHQIRVHLASLGVPV 257

Query: 176 IGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFG 235
           +GD+ +G  R   +G E     R +LHA +L + HP TG P+   A   +   + L + G
Sbjct: 258 LGDAVYGGARTAVAGVE-----RQLLHAWKLCVPHPATGTPMEFTAPPPEDIRRILERIG 312

Query: 236 WRGL 239
            + L
Sbjct: 313 VKTL 316


>UniRef50_A6C0W7 Pseudouridine synthase n=1 Tax=Planctomyces maris DSM 8797
           RepID=A6C0W7_9PLAN
          Length = 342

 Score = 93.2 bits (230), Expect = 8e-18,   Method: Compositional matrix adjust.
 Identities = 74/256 (28%), Positives = 120/256 (46%), Gaps = 40/256 (15%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV-VMQTVRDQI----GQH-VFTAHRLDR 55
           ++I+Y+D+W+  +NKPS  +VH    +    +   +Q   DQ+    GQ+     HRLDR
Sbjct: 93  IDIVYEDDWIAIINKPSDMIVHPGKGNYAGTLAGALQYHFDQLSDVAGQYRPGIVHRLDR 152

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL------MEEAVLDYPLVEELD 109
            TSG++++   ++    L+ QFE+  +QK Y AIV G +      ++  +  +P   E  
Sbjct: 153 NTSGIMVVAKDNQVHAKLSAQFEKRDVQKEYRAIVWGRMEFDTDYIDTFMCVHPRAREKM 212

Query: 110 KIADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLA 169
            + D    E    + A T+Y  +          RY    Y  V L+P+TGR HQLR H+ 
Sbjct: 213 IVCD----EGGNARNAFTYYEVIE---------RYQAFTY--VRLKPRTGRTHQLRVHMQ 257

Query: 170 HLRHPIIGDSKHG---DLRQNRSGAEHFG----------LQRLMLHASQLSLTHPFTGEP 216
           H+ H I+ D  +G    L+    G +             ++R  LHA  L   HP +G+P
Sbjct: 258 HIGHSIVADRVYGGHKSLKMKSLGIQAEADAAELESDVLIERQALHAYCLEFFHPQSGKP 317

Query: 217 LTIHAGLDDTWMQALS 232
           +   A L +     L+
Sbjct: 318 MKFEAPLPEDMQNTLA 333


>UniRef50_C8PW17 Pseudouridine synthase n=5 Tax=Moraxellaceae RepID=C8PW17_9GAMM
          Length = 365

 Score = 93.2 bits (230), Expect = 9e-18,   Method: Compositional matrix adjust.
 Identities = 66/216 (30%), Positives = 114/216 (52%), Gaps = 25/216 (11%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ-HVFTAHRLDRPTSGVLL 62
           I+Y+DE L+ +NKPSG  VH       E   V++ +R+  G+ ++   HR+D+ TSG+L+
Sbjct: 141 IVYEDEGLIVLNKPSGMAVHGGS---GESFGVIEAMREATGKKYLELVHRIDKDTSGLLM 197

Query: 63  MGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEA-VLDYPLVE------ELDKIADKF 115
           +       + L +   +  +QK Y  +V GW+  E   +D PL++      +  K  ++ 
Sbjct: 198 IAKKRSTLKTLQEHLREKTLQKTYLCLVVGWISSETQTIDKPLLKYTLPATQEGKSGERR 257

Query: 116 ARED---KGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLR 172
            + D   +  +P+ T    L   E+    G+    +  L+E +P TGR HQ+R HLA + 
Sbjct: 258 VKVDVKSEDSKPSQTQINVLQKFEL---NGQ----KVSLIEAKPLTGRTHQIRVHLASIG 310

Query: 173 HPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSL 208
           HP++GD K+     N +  +   ++RL LHA QL++
Sbjct: 311 HPLLGDDKYNP---NVAKGDKM-VRRLCLHAYQLAI 342


>UniRef50_C4Z9Y6 Pseudouridine synthase n=1 Tax=Eubacterium rectale ATCC 33656
           RepID=C4Z9Y6_EUBR3
          Length = 324

 Score = 92.8 bits (229), Expect = 9e-18,   Method: Compositional matrix adjust.
 Identities = 72/239 (30%), Positives = 118/239 (49%), Gaps = 25/239 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSW---LDRDEKVVVMQTVRDQIGQHVF------TAHR 52
           L ++Y+D+ ++A NKP   L  +S    +  +E+++       ++    +        +R
Sbjct: 93  LGVVYEDDDILAANKPVNMLSQKSKETDISANERLIGYLIKEGKLDFDTYKSFKPSVCNR 152

Query: 53  LDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLV--EELDK 110
           LDR TSG++LMG S    + L+Q  +    +K Y A+V G + E   ++  L   E ++K
Sbjct: 153 LDRNTSGLILMGKSLHGLQYLSQVLKARTAEKYYMALVAGEVDEPMTIEGFLTKDEAVNK 212

Query: 111 IADKFAREDKGPQ--PAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHL 168
           +  +  RE    +  P  T YR L T++M  +  +       L+E+   TGR HQ+R HL
Sbjct: 213 V--QITREPISDESLPIKTAYRPLKTIDMSASCHKAT-----LLEVHLITGRSHQIRAHL 265

Query: 169 AHLRHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTW 227
           + + HPIIGD K+GD R N    E++ +   +LHA      H    +   I A L D W
Sbjct: 266 SSIGHPIIGDIKYGDRRINAFYKENYHVTSQLLHAH-----HVILPDGRYIEAALPDIW 319


>UniRef50_D1VS73 Pseudouridine synthase n=1 Tax=Peptoniphilus lacrimalis 315-B
           RepID=D1VS73_9FIRM
          Length = 295

 Score = 92.8 bits (229), Expect = 9e-18,   Method: Compositional matrix adjust.
 Identities = 60/222 (27%), Positives = 110/222 (49%), Gaps = 25/222 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIGQ----HVFTAHRLDR 55
             ++Y+DE++  ++KP   +VH    +    +V  ++   ++Q+           HRLD+
Sbjct: 75  FNVIYEDEYIAVISKPQDLVVHIGAGNSSGTLVNGLLYKFKNQLSDLDPLRPGIVHRLDK 134

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKF 115
            TSG++++  +++A   L  QF+  QI+K Y AIV G   E  ++  P+    +    K 
Sbjct: 135 NTSGLMIIAKNNQAHINLVDQFKNSQIKKYYLAIVHGKTPESGIIAEPIGRNPND-RKKM 193

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
           A   K  + A+T Y+ L   +            Y L+ +   TGR HQ+R H+A++ +P+
Sbjct: 194 AVVYKNSKQAITKYKKLKEFQ-----------EYSLLNINLLTGRTHQIRVHMAYIGYPV 242

Query: 176 IGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPL 217
           +GD  +G  R+N        + + MLH+ +L   HP T + +
Sbjct: 243 LGDIIYG--RKNS-----LKIDKQMLHSYKLIFNHPITNQKM 277


>UniRef50_C8QZ10 Pseudouridine synthase n=1 Tax=Desulfurivibrio alkaliphilus AHT2
           RepID=C8QZ10_9DELT
          Length = 324

 Score = 92.8 bits (229), Expect = 9e-18,   Method: Compositional matrix adjust.
 Identities = 76/225 (33%), Positives = 113/225 (50%), Gaps = 19/225 (8%)

Query: 5   LYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIG----QHVFTAHRLDRPTS 58
           LY+DE ++ + KP G +VH +   R   +V  ++   R+  G          HRLD+ TS
Sbjct: 96  LYEDEDILVLVKPPGLVVHPADGHRQGTLVHGLLHHCRNLSGISGQLRPGIVHRLDKDTS 155

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           G L++  +  A   L QQF+  +++K Y A++RG L E+       +        K A  
Sbjct: 156 GCLVVAKNDLAHHNLVQQFKGREVEKTYQALLRGILAEDTGQVVLPIGRHPVHRKKMAVR 215

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
            +G + AVTH+R    V    + G      Y LVEL  +TGR HQ+R H+A L HP+ GD
Sbjct: 216 REGGREAVTHWR----VRQRFSAG------YTLVELLLETGRTHQIRVHMAALGHPLAGD 265

Query: 179 SKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGL 223
             +G   +N      +G+ R  LHA +L+  HP +G  LT  A L
Sbjct: 266 RLYG---RNPEKDMPYGIDRQWLHAWRLAFNHPRSGRRLTFTAPL 307


>UniRef50_A6TAT3 Pseudouridine synthase n=57 Tax=Bacteria RepID=A6TAT3_KLEP7
          Length = 263

 Score = 92.8 bits (229), Expect = 9e-18,   Method: Compositional matrix adjust.
 Identities = 75/225 (33%), Positives = 112/225 (49%), Gaps = 22/225 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           + +LYQDE LV +NKP+G L       R+   V  + V+   G      HRLD  TSG++
Sbjct: 48  ITLLYQDEHLVLINKPAGLLSLSGKDPRNLDSVHHRLVQRYPG--CTLVHRLDFGTSGLM 105

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADKFAREDK 120
           ++  +     LL QQF Q  + K Y A++ G L E E +++  + ++  +   + A   +
Sbjct: 106 VIARNKGINALLCQQFSQRTVDKVYTALLCGHLAEDEGIVEAAIAKDPARFP-RMALCAR 164

Query: 121 GPQPAVTHYRGLATV------EMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
             +PA + YR +  +      E  +A  R        V L P+TGR HQLR H   L +P
Sbjct: 165 HGKPARSRYRVIDRLYQAREGERALALTR--------VTLTPETGRTHQLRIHCQLLGYP 216

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTI 219
           I+G   +G   +   G E     RLMLHAS+L   HP + EP+ I
Sbjct: 217 ILGCDLYGG--RELPGTEQ--APRLMLHASELRFVHPVSHEPMHI 257


>UniRef50_C8P3R0 Pseudouridine synthase n=1 Tax=Erysipelothrix rhusiopathiae ATCC
           19414 RepID=C8P3R0_ERYRH
          Length = 308

 Score = 92.8 bits (229), Expect = 9e-18,   Method: Compositional matrix adjust.
 Identities = 68/241 (28%), Positives = 118/241 (48%), Gaps = 27/241 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVV------MQTVRDQIGQ-HVFTAHRLD 54
           L+I+Y+D+ ++ VNKP G +VH S    ++  +V         + D  G+      HR+D
Sbjct: 83  LDIVYEDDAILVVNKPKGLIVHPSPSTLNQPTLVHGLLAHTTQLSDLNGELRPGIVHRID 142

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIV-RGWLMEEAVLDYPLVEELDKIAD 113
           + T+G+L++  ++EA  +L +  +Q  I + Y AIV   +  + A +D P+  +  K   
Sbjct: 143 KDTTGLLVVAKTNEAHEILVEDLKQRLISREYVAIVHHQFKHQSATVDAPIGRD-PKNRQ 201

Query: 114 KFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
           + A  D+  + AVTH+             R+    + ++  +  TGR HQ+R H  +++H
Sbjct: 202 RMAVTDQNSKQAVTHF---------YLAERF--NDFSVLRCKLDTGRTHQIRVHAQYIKH 250

Query: 174 PIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           PI+GD       Q  S    +      LHA +L+LTHP + E +T  A L  T    + +
Sbjct: 251 PIVGD-------QTYSYKNTWETNGQCLHAQKLTLTHPVSKEVMTFEAELPQTMKDVIEE 303

Query: 234 F 234
            
Sbjct: 304 I 304


>UniRef50_Q1JVY6 Pseudouridine synthase n=1 Tax=Desulfuromonas acetoxidans DSM 684
           RepID=Q1JVY6_DESAC
          Length = 295

 Score = 92.8 bits (229), Expect = 1e-17,   Method: Compositional matrix adjust.
 Identities = 72/239 (30%), Positives = 113/239 (47%), Gaps = 33/239 (13%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSW--LDRDEKVVVMQTVRDQIGQH-VFTAHRLDRPTS 58
           L ILY+   ++ V+KPSG  +H S    DR+   +V + +R +   + V   HRLD  TS
Sbjct: 83  LFILYESREILIVDKPSGLAIHSSEGHQDRNLAALVDELIRSRGDAYQVAPIHRLDLETS 142

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           G +L G   +A   L + F  H+++K Y A+V G      ++         ++  K   +
Sbjct: 143 GPVLFGKGKKACSELGKLFMCHEVEKSYLALVAGKTPGRGLIQ-------SEVPSKGKTK 195

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
           +     A T ++ L   E           +  L+++   TGR+HQ+RR LA L HP+ GD
Sbjct: 196 E-----AQTAFQALDRNE-----------QASLLKVTLYTGRQHQIRRQLAELGHPLFGD 239

Query: 179 SKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWR 237
            ++        G +   L RL LH  QL+   PF+G P+ I++ L     Q L   G R
Sbjct: 240 RRY-------RGQQPDALPRLFLHCCQLAFIDPFSGAPVEINSPLPADLSQFLDTVGLR 291


>UniRef50_B1XXM0 Pseudouridine synthase n=6 Tax=Burkholderiales RepID=B1XXM0_LEPCP
          Length = 369

 Score = 92.8 bits (229), Expect = 1e-17,   Method: Compositional matrix adjust.
 Identities = 71/230 (30%), Positives = 110/230 (47%), Gaps = 23/230 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRS---WLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTS 58
           L ++++D  L+ ++KP+G +VH +   W       ++               HRLD+ TS
Sbjct: 119 LAVVHEDAHLLVIDKPAGLVVHPAAGHWSGTLLNGLLAHHAAAAHLPRAGIVHRLDKDTS 178

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEE-LDKIADKFA 116
           G++L+  S +A   L +      +++ Y A+V G +M+   V+D PL  + + ++     
Sbjct: 179 GLMLVAKSLQAHTALVRAIAARDVKREYLALVHGAVMDGLQVIDAPLGRDPVSRVRMAIV 238

Query: 117 REDKGPQPAVTHYRGLATVEMP-------VATGRYPTTRYGLVELEPKTGRKHQLRRHLA 169
              K   PA T  R LA  E+P           R P  +   V  +  TGR HQ+R HLA
Sbjct: 239 ASGK---PARTDVRRLAVAELPGDGVRQLPGATRAPR-QVSAVHCQLHTGRTHQIRVHLA 294

Query: 170 HLRHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTI 219
              HP++ D+ +G       GA  FGLQR  LHA++L L HP  G PL  
Sbjct: 295 SRGHPLLADAMYG-------GAPAFGLQRQALHAARLHLLHPIDGRPLAF 337


>UniRef50_Q2LWV4 Pseudouridine synthase n=1 Tax=Syntrophus aciditrophicus SB
           RepID=Q2LWV4_SYNAS
          Length = 333

 Score = 92.8 bits (229), Expect = 1e-17,   Method: Compositional matrix adjust.
 Identities = 82/262 (31%), Positives = 131/262 (50%), Gaps = 34/262 (12%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIG----QHVFTAHRLDR 55
           L ILY+D  L+ ++KP+G +VH +       +V  ++   RD  G          HRLD+
Sbjct: 85  LSILYEDHDLLVLDKPAGLVVHPAAGHVSGTLVNALLFHCRDLAGIGGVMRPGIVHRLDK 144

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPL----VEELDK 110
            TSG+L++  +  A + LA QF++HQ+ K Y A+V G   E+   +D P+    VE    
Sbjct: 145 DTSGLLVVAKTDAAHQGLALQFKKHQVGKTYQALVYGDPREKTGQIDLPVGRHPVER--- 201

Query: 111 IADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAH 170
              K + + +  + A T +R        VAT         L+ ++  TGR HQ+R HLA 
Sbjct: 202 --KKMSTKSRRGKEAATRWR--IAERFGVAT---------LLNVDIVTGRTHQIRVHLAA 248

Query: 171 LRHPIIGDSKHGDLRQNRSGAEHFGLQRL------MLHASQLSLTHPFTGEPLTIHAGLD 224
           + HP++GD+ +G  ++  +  +     RL       LHA++LS THP T + L  HA L 
Sbjct: 249 IGHPVVGDAVYGSSKRATTLTDPAVKGRLKEMSRQALHAARLSFTHPVTHKILEFHAPL- 307

Query: 225 DTWMQALSQFGWRGLLPENERV 246
              M+ L  F  +   P+++ V
Sbjct: 308 PADMEDLCAFLRKHCCPDSQLV 329


>UniRef50_A4J1I1 Pseudouridine synthase n=1 Tax=Desulfotomaculum reducens MI-1
           RepID=A4J1I1_DESRM
          Length = 303

 Score = 92.8 bits (229), Expect = 1e-17,   Method: Compositional matrix adjust.
 Identities = 70/238 (29%), Positives = 119/238 (50%), Gaps = 25/238 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKV---VVMQTVRDQIGQHVFTAHRLDRPTS 58
           L I+ +DE +  VNK  G  VH +       +   +V   + +         +R+DR TS
Sbjct: 83  LSIISEDEDIALVNKQPGMCVHPTLAYPSGTLANGLVYHWLENNPAPTFHAVNRIDRNTS 142

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADKFAR 117
           G++L+  +S + + L  Q ++ Q+ + Y A+V G +++    +D PL E+ +    K   
Sbjct: 143 GLVLVAKNSYSAQKLFLQRKRKQLARSYVALVHGKIVQRNGYIDLPL-EKCEGKTTKRQI 201

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
              G Q A+T +  L  +           T   L+ L P+TGR HQ+R HL+HL HP++G
Sbjct: 202 SSTGQQ-ALTRFEVLQYI-----------TDCTLIRLMPETGRTHQIRVHLSHLGHPLVG 249

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFG 235
           D+ +G      S A+   + R  LHA ++S  HP TG P++    L +  +Q +++ G
Sbjct: 250 DTLYGG-----SIAQ---IGRHCLHADKISFLHPRTGHPMSFQIPLAEDMLQVITEMG 299


>UniRef50_A6DUC9 Pseudouridine synthase n=1 Tax=Lentisphaera araneosa HTCC2155
           RepID=A6DUC9_9BACT
          Length = 323

 Score = 92.4 bits (228), Expect = 1e-17,   Method: Compositional matrix adjust.
 Identities = 67/247 (27%), Positives = 117/247 (47%), Gaps = 31/247 (12%)

Query: 2   LEILYQDEWLVAVNKPSGWLVH-----------RSWLDRDEKVVVMQTVRDQIGQHVFTA 50
           L+I+Y+D+ ++ VNKP+G +VH            + L RD       +  D         
Sbjct: 90  LDIIYEDDDILVVNKPAGMVVHPGAGNYTGTLVNALLGRDLDTF---SAMDDGSSRPGIV 146

Query: 51  HRLDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM--EEAVLDYPLVEEL 108
           HRLD+ TSGV+++  S++    L++ F +  ++K Y A+ RG +    + +  +      
Sbjct: 147 HRLDKETSGVIIVAKSAKNLDKLSRSFARRDVEKYYVALCRGTIRVGRDTITSHIGRSRS 206

Query: 109 DKIADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHL 168
           ++   +   +    + A++HY+ LA                 LV+L+  TGR HQ+R H+
Sbjct: 207 NRQKMENTNDSNRGKEAISHYKVLA-----------DNNGATLVKLKIDTGRTHQIRVHM 255

Query: 169 AHLRHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWM 228
           + + HP++GD  +G  R +    E     R +LHA +  + HP T E +T  A L D + 
Sbjct: 256 SGINHPVVGDKLYGVRRLD----EKESPDRHILHAWRTRIIHPGTQEIMTFTAPLHDDFK 311

Query: 229 QALSQFG 235
               +FG
Sbjct: 312 SVCDKFG 318


>UniRef50_Q14NK8 Probable pseudouridine synthase d protein n=1 Tax=Spiroplasma citri
           RepID=Q14NK8_SPICI
          Length = 306

 Score = 92.4 bits (228), Expect = 1e-17,   Method: Compositional matrix adjust.
 Identities = 78/247 (31%), Positives = 122/247 (49%), Gaps = 31/247 (12%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTA---------HR 52
           L ILY+D +L+ ++KP+  +VH +   +++ +V     R   G    TA         HR
Sbjct: 81  LTILYEDSYLMVIDKPNNLVVHPAPGHQNDTLVNALLAR---GVQWSTASGEQRPGIVHR 137

Query: 53  LDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKI 111
           +DR T+G L++  +      L QQ +  Q+Q+RY A+V G ++E  A +D P+  + +  
Sbjct: 138 IDRQTTGTLIIAKNDVVHHQLQQQIQTKQLQRRYLALVHGQIIENRAKIDAPIGRDPNN- 196

Query: 112 ADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHL 171
             K     K  + A+T+          V   R+    Y  +E E ++GR HQ+R HL ++
Sbjct: 197 RKKMVVTAKNSKKALTNI---------VVIERF--NDYTYIECELESGRTHQIRAHLKYI 245

Query: 172 RHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
            HPI+GD  +G +   +   E FG     LHA QL   HP T E LTI A L   + Q L
Sbjct: 246 NHPIVGDPLYGTVADKK---ESFG---QYLHAYQLRFIHPVTKESLTITAALPQEFEQRL 299

Query: 232 SQFGWRG 238
           +    +G
Sbjct: 300 AILRAKG 306


>UniRef50_C1CWT3 Pseudouridine synthase n=1 Tax=Deinococcus deserti VCD115
           RepID=C1CWT3_DEIDV
          Length = 321

 Score = 92.4 bits (228), Expect = 1e-17,   Method: Compositional matrix adjust.
 Identities = 80/259 (30%), Positives = 119/259 (45%), Gaps = 39/259 (15%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVR----------DQIGQHVFTAH 51
           L+++Y+D++L+AVNKP G + H +       +V     R           + G      H
Sbjct: 77  LDVIYEDDYLIAVNKPPGMVTHPAPGVLSGTLVNALLGRMPLPEQPDYDSEAGYRPGIVH 136

Query: 52  RLDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRG-WL------MEEAVLDYPL 104
           RLD+ TSGV+++  +  A   LA  F+  + +K Y AI  G W       +E  +  +P+
Sbjct: 137 RLDKDTSGVIVVAKTVGAHARLAAAFKDRETRKTYLAIAAGQWRADGPARVEAPIGRHPV 196

Query: 105 VEELDKIADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQL 164
             +   +     RE      A T +  LA    P   GR       LV  +P+TGR HQ+
Sbjct: 197 QRQRMTVGGANPRE------AQTLFTPLAA--HPDGHGRT----LALVRAQPRTGRTHQI 244

Query: 165 RRHLAHLRHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLD 224
           R HLAHL  PI+GD+ +G   +         + R  LHA  LS+ HP TG  L +HA   
Sbjct: 245 RVHLAHLGSPILGDAVYGRSSET--------MLRHALHAHFLSVPHPGTGRLLHLHAPAP 296

Query: 225 DTWMQALSQFGWRGLLPEN 243
           D  + A    G  G +P +
Sbjct: 297 DDMLNAWIALG--GAMPSD 313


>UniRef50_C6JBH1 Pseudouridine synthase n=1 Tax=Ruminococcus sp. 5_1_39BFAA
           RepID=C6JBH1_9FIRM
          Length = 299

 Score = 92.4 bits (228), Expect = 1e-17,   Method: Compositional matrix adjust.
 Identities = 67/234 (28%), Positives = 115/234 (49%), Gaps = 25/234 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIGQHVF-TAHRLDRPTS 58
           L I+Y+DE ++ +NKP+   VH S  + +  +   +     ++    V+   +RLDR T+
Sbjct: 81  LNIIYEDEDILVINKPADMPVHPSAGNYENTLANGIAWYFAEKGEDFVYRCINRLDRDTT 140

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           G L++  +  +  +L+ Q ++ QI + Y A+V G L +   ++ P+      +  +    
Sbjct: 141 GALILAKNPLSAAILSVQMKKRQILRTYLALVDGLLPDSGTINAPIARMEGSVITREVNF 200

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
             G + A+THY  LA        G+     Y L EL  +TGR HQ+R H+ ++ HP+ GD
Sbjct: 201 GTG-ESAITHYERLAA-------GK----EYSLAELHLETGRTHQIRVHMKYIGHPLPGD 248

Query: 179 SKHG-DLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
             +  D R+         + R  LH+ QL  THP TG+ +   A L   ++ A 
Sbjct: 249 YLYNPDYRR---------INRQPLHSYQLEFTHPTTGKVMLFTAPLPIDFISAF 293


>UniRef50_D2L0S2 Pseudouridine synthase, RluA family n=1 Tax=Desulfovibrio sp.
           FW1012B RepID=D2L0S2_9DELT
          Length = 558

 Score = 92.4 bits (228), Expect = 1e-17,   Method: Compositional matrix adjust.
 Identities = 76/225 (33%), Positives = 110/225 (48%), Gaps = 20/225 (8%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVV-----MQTVRDQIGQHVFTAHRLDRP 56
           L +LY D+ L  ++KP G  VH +    +  +V         +R+  G+     HRLD+ 
Sbjct: 91  LRVLYADKELAVLDKPPGLTVHPAPGLPEGTLVNRLLHHFPGLREMAGERPGIVHRLDKD 150

Query: 57  TSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADKF 115
           TSG+L++ L+      LA  F   Q+ K Y A+V G    +   +  P+  +  K   K 
Sbjct: 151 TSGLLMVALTEPVRLALAADFAARQVHKTYLALVHGRPDGKGGDIRLPIGRD-PKYRTKM 209

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
           A   KG +PA + +R       PV T   P     L+E+   TGR HQ+R H+A + HPI
Sbjct: 210 AVPHKGGRPAHSRWR-------PVWTA--PDGTASLLEVTIFTGRTHQIRVHMAAIGHPI 260

Query: 176 IGDSKHGDLR----QNRSGAEHFGLQRLMLHASQLSLTHPFTGEP 216
           IGD+ +G  +    + R GA      R MLHA +LS THP   EP
Sbjct: 261 IGDAVYGPHQHAAWKRRGGAIARLASRQMLHAWKLSFTHPVLKEP 305


>UniRef50_C4XFS9 Pseudouridine synthase n=2 Tax=Mycoplasma RepID=C4XFS9_MYCFE
          Length = 315

 Score = 92.4 bits (228), Expect = 1e-17,   Method: Compositional matrix adjust.
 Identities = 70/249 (28%), Positives = 124/249 (49%), Gaps = 26/249 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIGQHVF-----TAHRLD 54
           L+I Y+D+ LV +NKPS  +VH S    ++ +V  ++   ++ +            HR+D
Sbjct: 84  LDIKYEDDDLVIINKPSNLVVHPSPGHYNDTLVNGLLYHFKNNLSNENGLLRPGIVHRID 143

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADK 114
           + TSG+L++  +++    L    ++H+I++ Y AIVRG L+E  +    L    + +  K
Sbjct: 144 KDTSGLLIIAKNNKMHNSLTDMLKRHEIERSYLAIVRG-LIENPLTKINLPIARNTVDRK 202

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
                K  + A+T    L    +     + P +   LV  E KTGR HQ+R HL++++HP
Sbjct: 203 MMSVHKEGKEAITFVHLLKHFYL----DKEPMS---LVRCELKTGRTHQIRVHLSYIKHP 255

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           + GD  +G         + F  QR  LHA +L   HP T + + ++A +   +   ++ +
Sbjct: 256 VYGDPTYG------KSVDEFN-QR--LHAYKLKFIHPLTKKEICVYAPVPKEF--DVADY 304

Query: 235 GWRGLLPEN 243
            +  LL  N
Sbjct: 305 DFNELLKNN 313


>UniRef50_O31613 Uncharacterized RNA pseudouridine synthase yjbO n=53
           Tax=Bacillaceae RepID=YJBO_BACSU
          Length = 283

 Score = 92.4 bits (228), Expect = 1e-17,   Method: Compositional matrix adjust.
 Identities = 75/236 (31%), Positives = 114/236 (48%), Gaps = 45/236 (19%)

Query: 2   LEILYQDEWLVAVNK------------PSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFT 49
           L+ILY+DE ++ +NK            PSG + +   +D  +   V  TV      H+ T
Sbjct: 66  LDILYEDEHVLVINKQPYVSSIPSREHPSGSIAN-GIIDHYQTTGVRATV------HLVT 118

Query: 50  AHRLDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEEL 108
             RLDR TSG++L+     A  +L+   +   +++RY A+V G + + E  +D P+    
Sbjct: 119 --RLDRDTSGIMLVAKHRFAHSILSSAQKNGLVKRRYAAVVHGRMAQMEGTVDAPIGRHP 176

Query: 109 DKIADKFAREDKGPQPAVTH-YRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRH 167
           D I ++    D   Q AVTH Y   A  +M              V L+ +TGR HQ+R H
Sbjct: 177 DSIIERTVTPDG--QKAVTHFYVTCANDDMTS------------VALQLETGRTHQIRVH 222

Query: 168 LAHLRHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGL 223
           +++L HP+ GD+ +G  RQ         + R  LH+  LS  HP T E +  HA L
Sbjct: 223 MSYLGHPLCGDTLYGGTRQE--------IGRQALHSEHLSFIHPLTQENMRFHAPL 270


>UniRef50_A7HM17 Pseudouridine synthase n=2 Tax=Thermotogaceae RepID=A7HM17_FERNB
          Length = 314

 Score = 92.4 bits (228), Expect = 1e-17,   Method: Compositional matrix adjust.
 Identities = 70/245 (28%), Positives = 120/245 (48%), Gaps = 31/245 (12%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIGQHVF----TAHRLDR 55
           L+I+Y+D  ++ +NK  G + H         +V  V+   +D  G          HRLD+
Sbjct: 79  LDIIYEDRDILVINKQPGIITHPIPSHTSGTIVNGVLYHCKDLQGIGGVLRPGIVHRLDK 138

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL------MEEAVLDYPLVEELD 109
            TSGV+++  +  A + L +QF+    +K Y  +V+G        +E  +   P++    
Sbjct: 139 DTSGVMVIAKNDLAHQSLTKQFKDRLTEKLYICLVKGVPKRKEGDIEINIARNPVL---- 194

Query: 110 KIADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLA 169
           ++       + G +PA+THY+ +          R       LV   PKTGR HQ+R H+ 
Sbjct: 195 RVKMTVTNSEYG-KPALTHYKVV----------REFGDIAALVFAYPKTGRTHQIRVHMK 243

Query: 170 HLRHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQ 229
           ++ HP++GD  +G  +++    E FG++R MLHA  LS  HP TGE +   A +   + +
Sbjct: 244 YIGHPLMGDEVYGRAKED----EIFGIKRQMLHALSLSFYHPRTGEKVKFIAKIPQDFKE 299

Query: 230 ALSQF 234
           A+ + 
Sbjct: 300 AIQKL 304


>UniRef50_A0Y082 Pseudouridine synthase n=2 Tax=Alteromonadales RepID=A0Y082_9GAMM
          Length = 235

 Score = 92.0 bits (227), Expect = 2e-17,   Method: Compositional matrix adjust.
 Identities = 71/226 (31%), Positives = 110/226 (48%), Gaps = 22/226 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ-----HVFTAHRLDRP 56
             ILYQD  ++ +NKPSG L        +   V  + V  Q G           HRLD  
Sbjct: 22  FSILYQDNDILVINKPSGLLSLSGKNSENWDSVHYRLVNGQKGLTPAFLKAKLVHRLDLG 81

Query: 57  TSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADKF 115
           TSG++L+ L+  + + L +QF+   ++K Y A+++G + E+   +D P+ ++        
Sbjct: 82  TSGIMLVSLNDVSSKHLNKQFQLRSVKKHYVAVLQGCISEDRGQIDAPIAKDTQLFPRVK 141

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
             + +G +PAVT +  +  +  PV T          V   P TGR HQLR H   + HPI
Sbjct: 142 ICKLEG-KPAVTEFNVIKRLANPVRT---------YVHFSPLTGRTHQLRIHSHFIGHPI 191

Query: 176 IGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHA 221
           +G     DL ++ + +E    +RL LHAS L   HP T + + IH 
Sbjct: 192 LG----CDLYKS-AHSEKLS-KRLQLHASDLFFEHPTTNQAIHIHC 231


>UniRef50_Q2LVB7 Pseudouridine synthase n=1 Tax=Syntrophus aciditrophicus SB
           RepID=Q2LVB7_SYNAS
          Length = 324

 Score = 92.0 bits (227), Expect = 2e-17,   Method: Compositional matrix adjust.
 Identities = 70/228 (30%), Positives = 122/228 (53%), Gaps = 25/228 (10%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQI-GQ-HVFTAHRLDRPTSGVL 61
           +L++D+ ++AV KP G     +      + +V Q +++   G+ H F  HRLD+  SGVL
Sbjct: 109 VLFEDQHVIAVEKPVGIATFSADGSASVQWIVAQALKEHSRGKIHAFAVHRLDKEVSGVL 168

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADKFAREDK 120
           L   S  A   + +++++   +KRY+A+V G     +  ++  LVE+  +      RE  
Sbjct: 169 LFAKSKMAMDHIKEKWKE--AEKRYYALVEGKPESPDGTIESWLVEDHAQKVHS-TRESS 225

Query: 121 GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSK 180
             + +VTHYR +  V            +Y L++++ +TGRK+Q+R HL+ +  PI GD K
Sbjct: 226 KAKFSVTHYRIIKQV-----------NQYTLLDVKLQTGRKNQIRVHLSDIGCPIAGDRK 274

Query: 181 HGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWM 228
           +G        A  F ++R+ LHA  LS  HP TGE ++I + + + ++
Sbjct: 275 YG-------AAADF-VRRIRLHAYYLSFPHPVTGERISIESPMPEGFL 314


>UniRef50_A5ZUU7 Pseudouridine synthase n=1 Tax=Ruminococcus obeum ATCC 29174
           RepID=A5ZUU7_9FIRM
          Length = 293

 Score = 92.0 bits (227), Expect = 2e-17,   Method: Compositional matrix adjust.
 Identities = 61/239 (25%), Positives = 110/239 (46%), Gaps = 35/239 (14%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTA---------HR 52
           + +LY+DE ++ VNKP+   VH S  +         T+ + +  ++ T          +R
Sbjct: 81  IPVLYEDEDILVVNKPADMPVHPSLGN------YTNTLANGVAAYLETKGESCPFRCINR 134

Query: 53  LDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIA 112
           LDR TSG L++  ++ +  +L+ Q    QI + Y A+V G   +   +  P+    D + 
Sbjct: 135 LDRDTSGALILAKNALSAAILSVQMRNRQISRTYLAVVEGIPRQSGTISAPISRAADSVI 194

Query: 113 DKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLR 172
           ++    + G + A+THY+ L                + L+E+  +TGR HQ+R H+ ++ 
Sbjct: 195 ERRIDFENG-ESAITHYQLLEV-----------KNNHSLLEIHLETGRTHQIRVHMGYIG 242

Query: 173 HPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
           HP+  D  +  +            +R  LH+ QL   HP TG P+ + A + +    A 
Sbjct: 243 HPLPADYLYNPVYDT--------FKRQPLHSLQLKFCHPITGTPMCLMAPVPEDMSNAF 293


>UniRef50_UPI00016B2413 ribosomal large subunit pseudouridine synthase, RluD subfamily
           protein n=3 Tax=candidate division TM7
           RepID=UPI00016B2413
          Length = 379

 Score = 92.0 bits (227), Expect = 2e-17,   Method: Compositional matrix adjust.
 Identities = 71/219 (32%), Positives = 102/219 (46%), Gaps = 40/219 (18%)

Query: 3   EILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFT-----AHRLDRPT 57
           E +Y+D  ++ +NKP+G L H      +E       V+        T      HRLDR T
Sbjct: 175 ETIYEDNDIIVINKPAGMLTHAKGAIAEE-FTAADIVKPITNYKADTNRPGIIHRLDRNT 233

Query: 58  SGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADKFA 116
           SGVLLM  +S+A   + +QF Q  ++K Y+AIV G   + +A++D P+            
Sbjct: 234 SGVLLMVKNSDAASKIQKQFSQRTVKKTYYAIVCGIPYQHKALIDLPI------------ 281

Query: 117 REDKGPQPAVTHYRGLATVEMPVATGRYPTTR------YGLVELEPKTGRKHQLRRHLAH 170
             ++ P    T   G   V    A   Y   R        L++L+PKTGR HQLR H+ +
Sbjct: 282 --ERNPSRPSTFRVG---VNGKSAQTSYEVERSIIKKNISLIKLQPKTGRTHQLRVHMQY 336

Query: 171 LRHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLT 209
           L  PI+GD  +G        AE     R+ LHA  L +T
Sbjct: 337 LNTPILGDLVYGG-----KPAE-----RMFLHAESLEVT 365


>UniRef50_C9KIU1 Pseudouridine synthase n=3 Tax=Veillonellaceae RepID=C9KIU1_9FIRM
          Length = 296

 Score = 92.0 bits (227), Expect = 2e-17,   Method: Compositional matrix adjust.
 Identities = 73/238 (30%), Positives = 112/238 (47%), Gaps = 26/238 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKV--VVMQTVRDQIGQHVF-TAHRLDRPTS 58
           L+I Y+D++L+ VNKP+G LVH +  +    +   V+   +     H +   HRLDR TS
Sbjct: 78  LDIRYEDDYLLIVNKPAGQLVHPTTKEAHGTLGNAVLYWYKAHGEHHAYHPVHRLDRNTS 137

Query: 59  GVLLMGLSSEAG-RLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADKFA 116
           G++L+    +   +L  +  E     + Y A++ G L   E ++D P+   L  I  +  
Sbjct: 138 GLVLIAKVPQVQYKLTPRHGEGKLFHREYLALIEGELTPPEGLIDAPIARALPSIILRKV 197

Query: 117 REDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPII 176
             D   Q A THY  + T             +  L+ L   TGR HQ+R HLAHL HP++
Sbjct: 198 SPDG--QTARTHYDTVQT-----------DGKLSLIHLVLDTGRTHQIRVHLAHLGHPLL 244

Query: 177 GDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           GD  +        G     ++R  LHA++L   HP TG  + +   L     Q +S F
Sbjct: 245 GDDLY--------GGNLARIKRQALHAARLHFRHPMTGAEIDVQVPLPSDMAQIVSDF 294


>UniRef50_Q6AJM1 Pseudouridine synthase n=1 Tax=Desulfotalea psychrophila
           RepID=Q6AJM1_DESPS
          Length = 327

 Score = 92.0 bits (227), Expect = 2e-17,   Method: Compositional matrix adjust.
 Identities = 74/246 (30%), Positives = 122/246 (49%), Gaps = 21/246 (8%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRD--QIGQHVF--TAHRLDR 55
            E +Y+D+ L+ ++KP G +VH    + +  +V  ++   R+   +G  +     HRLD+
Sbjct: 95  FESIYEDDSLLVLSKPPGIVVHPGNGNTEGTLVHGLLYHCREIGGVGDAIRPGIVHRLDK 154

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADK 114
            TSG +++     + R L   F++ Q+ K YHA+V G   + E  +  P+         K
Sbjct: 155 DTSGAMVVAKDERSLRTLVDSFKERQVYKVYHALVCGIPKKYEGRIVAPIGRH-SVHRQK 213

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
            A  ++  + A T+++ +   E    T   P   Y L+ +  +TGR HQ+R H++ +  P
Sbjct: 214 MAISERTGKFAATNWQVVEVFE----TKDGP---YSLLRVHIETGRTHQIRVHMSSIGCP 266

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           I GD  +G  RQN + A      R MLHAS+L L HP TG  ++  A L   + + L   
Sbjct: 267 IAGDQVYGSKRQNPAFA------RQMLHASRLRLPHPVTGRTMSFTAPLWQDFQEVLEDM 320

Query: 235 GWRGLL 240
            W G L
Sbjct: 321 DWSGAL 326


>UniRef50_B9XDK1 Pseudouridine synthase n=1 Tax=bacterium Ellin514
           RepID=B9XDK1_9BACT
          Length = 283

 Score = 92.0 bits (227), Expect = 2e-17,   Method: Compositional matrix adjust.
 Identities = 75/250 (30%), Positives = 119/250 (47%), Gaps = 41/250 (16%)

Query: 1   MLEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAH--------- 51
           ++ ILY+D  ++AV+KP+GW++     D+  + + +  ++  +    F AH         
Sbjct: 15  LIPILYEDRSVLAVDKPAGWMLAPDSWDKTGRNLQL-ALQSSLNAGDFWAHSRNIKFLRY 73

Query: 52  --RLDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRG------WLMEEAVLDYP 103
             RLD  T+GVLL+  S  A R   + FE   ++K Y A+V+G      W  +  ++  P
Sbjct: 74  VHRLDAETTGVLLLCKSLGALRAYGELFETRSVEKFYLAVVQGIPKQSEWTCKLPLIADP 133

Query: 104 LVE---ELDKIADKFARED-KGPQP----AVTHYRGLATVEMPVATGRYPTTRYGLVELE 155
           +V+   ++        + D +GPQ     A TH+R + T++              LVE +
Sbjct: 134 VVKGKMQVVTPGKPLPKSDPRGPQAELKDAETHFRVIQTLQ-----------DKALVEAQ 182

Query: 156 PKTGRKHQLRRHLAHLRHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGE 215
           P TGR HQ+R HLA   HPI+GD  +G    N   A   G Q + L A +L    PF   
Sbjct: 183 PMTGRTHQIRVHLAASGHPIVGDPLYG----NAPAAASKGAQIIALRAIKLIYWDPFQKR 238

Query: 216 PLTIHAGLDD 225
            + I A  D+
Sbjct: 239 QIRIAAPTDE 248


>UniRef50_B7PYG1 Ribosomal pseudouridine synthase, putative n=1 Tax=Ixodes
           scapularis RepID=B7PYG1_IXOSC
          Length = 443

 Score = 92.0 bits (227), Expect = 2e-17,   Method: Compositional matrix adjust.
 Identities = 69/209 (33%), Positives = 96/209 (45%), Gaps = 41/209 (19%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRD-------QIGQHVFTAHRLDRP 56
           +LY D  ++ +NKP G L H       +  V+ + + D       +    ++T HRLDR 
Sbjct: 184 VLYNDNDILVLNKPYGMLCHGPAPGVSDACVLTKLLPDLSSALYPRQDAKLYTVHRLDRD 243

Query: 57  TSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVE--------- 106
            +GVLL+  +     +L   F++HQ+ K Y AI  G     E V+D PL E         
Sbjct: 244 VTGVLLLARTQRMADMLNSLFQKHQVSKTYLAITAGVPDHLEGVIDMPLAEGEVEGAKRM 303

Query: 107 --------ELDKIADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKT 158
                   E  ++  KF +       AVT YR LA+             R G +EL P T
Sbjct: 304 VLNPKLDPEFQRLVPKFRKS----FAAVTTYRVLASC-----------GRAGYLELRPTT 348

Query: 159 GRKHQLRRHLA-HLRHPIIGDSKHGDLRQ 186
           G KHQLR HL   LR PI+GD K+  LR+
Sbjct: 349 GVKHQLRAHLGLGLRCPILGDHKYSHLRR 377


>UniRef50_Q7UUI8 Pseudouridine synthase n=1 Tax=Rhodopirellula baltica
           RepID=Q7UUI8_RHOBA
          Length = 321

 Score = 91.7 bits (226), Expect = 2e-17,   Method: Compositional matrix adjust.
 Identities = 73/247 (29%), Positives = 120/247 (48%), Gaps = 25/247 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVR-----DQIGQHVFTAHRLDRP 56
            EI+++DE ++ VNK +G L      DR E   ++  V       +  +  F  HRLDR 
Sbjct: 84  FEIVFEDEHIIVVNKSAGTLT--VPTDRGEPNSLVDRVSIYLSYSKSKKEAFVVHRLDRE 141

Query: 57  TSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLV--EELDKIAD 113
           TSG+L+ G       LL +QF+  +  + +HAIV G + E E   +  L     LD+   
Sbjct: 142 TSGLLVFGKHEPIADLLIEQFKDRRPTRVFHAIVAGNVSEDEGTFESHLATGSNLDRYE- 200

Query: 114 KFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
              R  K    A+THY+ +  +    ++    TT   L+E + +T +++Q+R   A+  H
Sbjct: 201 --TRPGKDTDQAITHYKVVRRLAERESSHGEETT---LIEAQLETSKRNQVRVQFANAGH 255

Query: 174 PIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           P++GD ++   +   +    +  +R+ LHAS L   HP +GEP+      D     A+ +
Sbjct: 256 PVLGDPRY---KPKEATHARWHRKRMALHASTLGFFHPVSGEPV----NFDTPLPSAMEK 308

Query: 234 F--GWRG 238
           F  G RG
Sbjct: 309 FVAGARG 315


>UniRef50_A4J9H9 Pseudouridine synthase n=2 Tax=Clostridiales RepID=A4J9H9_DESRM
          Length = 320

 Score = 91.7 bits (226), Expect = 2e-17,   Method: Compositional matrix adjust.
 Identities = 68/235 (28%), Positives = 118/235 (50%), Gaps = 25/235 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVH---RSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTS 58
           +E+LY+D++L+ +NKP+  LVH   ++        +     +  +   +   HRLDR TS
Sbjct: 102 IEVLYEDDFLLVLNKPAHQLVHPTGQTTRGTMANYLAYYLKQRNVVSAIRPVHRLDRETS 161

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEA-VLDYPLVEELDKIADKFAR 117
           G ++    S +  +L QQ ++  +++ Y A+V+G +   +  +D P+      +A++ A 
Sbjct: 162 GCVIFAKDSRSQFILEQQLKERTLKRTYWALVKGIVHPPSGTIDAPIGPH-PSLANRRAI 220

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
            + G Q ++THY+ L +         +P     L++L   TGR HQ+R HLAHL +PIIG
Sbjct: 221 NEHGEQ-SITHYQTLRS---------FPEI--SLLKLNLDTGRTHQIRLHLAHLGYPIIG 268

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALS 232
           D  +        G     + R  LHA  +S  H      + +HA L   + QA++
Sbjct: 269 DRMY--------GVRSPWINRQALHAYDVSFRHLKENHEIAVHAPLPTDFAQAIN 315


>UniRef50_C8PVB8 Pseudouridine synthase n=2 Tax=Moraxellaceae RepID=C8PVB8_9GAMM
          Length = 380

 Score = 91.7 bits (226), Expect = 2e-17,   Method: Compositional matrix adjust.
 Identities = 73/245 (29%), Positives = 115/245 (46%), Gaps = 27/245 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV---VMQTVRDQIGQHVFTAHRLDRPTS 58
           L+ILY+DE ++ +NKP G +VH    +    +V   +      +        HR+D+ TS
Sbjct: 143 LDILYEDEAVLVINKPVGLVVHPGAGNGSGTLVNALLFHYPDSRTLPRAGLVHRIDKETS 202

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEA---VLDYPLVEELDKIADKF 115
           G++++   S++   L  Q +   + + Y AIV     E A    +D P+     +   K 
Sbjct: 203 GLMVIAKDSQSQLHLINQLKDKSVYRLYQAIVLASAAELARHRTIDAPIGRHPTQ-RTKM 261

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
           A    G +PAVTH   +  +   V+          LV +  +TGR HQ+R HL++L  P+
Sbjct: 262 AVVSSG-KPAVTHLEKITAISDAVS----------LVSVRLETGRTHQIRVHLSNLGFPL 310

Query: 176 IGDSKHGDLRQNR-------SGAEHF--GLQRLMLHASQLSLTHPFTGEPLTIHAGLDDT 226
           +GD  +G  R+N           +H     QR  LHA +L   HP TGEP+ + A L + 
Sbjct: 311 LGDPLYGAARKNAILLKTLDDDQKHIVQQFQRQALHAYELGFIHPKTGEPIKVQARLPED 370

Query: 227 WMQAL 231
             Q L
Sbjct: 371 MQQLL 375


>UniRef50_C0QV86 Pseudouridine synthase n=2 Tax=Brachyspira RepID=C0QV86_BRAHW
          Length = 329

 Score = 91.7 bits (226), Expect = 2e-17,   Method: Compositional matrix adjust.
 Identities = 70/237 (29%), Positives = 121/237 (51%), Gaps = 28/237 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQ--IG--QHVFTAHRLDR 55
           L+ILY+D++L+ +NKP+G  VH S  +    +V  ++  ++D   +G  +     HRLD+
Sbjct: 109 LDILYEDKYLLVINKPAGMSVHCSPSEMSGTLVNALLYKIKDFDFVGNKERAGIIHRLDK 168

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAV-LDYPLVEELDKIADK 114
            TSG++++G ++     + +QF+   I+K YHAIV G L +  + ++ P+          
Sbjct: 169 DTSGLMIIGKNANIVSSIQEQFKNRTIKKIYHAIVVGVLKDNYIEINLPIGRHHVYRKKM 228

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
             RED   + A+TH + L          R+ +  + L+E+  KTGR HQ+R H ++   P
Sbjct: 229 TVRED--GKEALTHIKVLK---------RFNS--HTLIEINLKTGRTHQIRVHSSYKGFP 275

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
           + GD  +      +S +++ G   LML A ++   HP T E L       D +   L
Sbjct: 276 VAGDKIYS-----KSFSKYSG---LMLVAKKIEFMHPITKELLDFEIDYPDYFTNFL 324


>UniRef50_B0PEI9 Pseudouridine synthase n=5 Tax=Bacteria RepID=B0PEI9_9FIRM
          Length = 338

 Score = 91.7 bits (226), Expect = 2e-17,   Method: Compositional matrix adjust.
 Identities = 62/215 (28%), Positives = 112/215 (52%), Gaps = 38/215 (17%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHR-------SWLDRDEKVVVMQTVRDQIGQHVFT---AH 51
           ++I+Y+DE ++ VNKP+G +VH        + ++R +  +    V +   ++ F     +
Sbjct: 101 IDIIYEDENILLVNKPAGLVVHEDEHQSSDTLINRIQHHLYNCGVYNPAEENSFAPALCN 160

Query: 52  RLDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKI 111
           R+DR T+G+++   ++ A R+L ++ +  ++QK Y  IV G + +E+       + L   
Sbjct: 161 RIDRNTAGIVIAAKNAAALRILNEKIKARELQKLYLCIVHGTMPKES-------DTLKAF 213

Query: 112 ADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRY---------GLVELEPKTGRKH 162
             K AR +            +A  + P+  GR   T Y          L+E++  TGR H
Sbjct: 214 LRKDARTNT-----------VAVYDHPIPDGRTILTHYRVVAQKDRLSLLEIDLLTGRTH 262

Query: 163 QLRRHLAHLRHPIIGDSKHGDLRQN-RSGAEHFGL 196
           Q+R HLAH+ HP++GD+K+G  R N ++G +H  L
Sbjct: 263 QIRAHLAHIGHPLLGDAKYGRNRDNHKTGLKHQAL 297


>UniRef50_Q5WF07 Pseudouridine synthase n=1 Tax=Bacillus clausii KSM-K16
           RepID=Q5WF07_BACSK
          Length = 301

 Score = 91.7 bits (226), Expect = 2e-17,   Method: Compositional matrix adjust.
 Identities = 75/234 (32%), Positives = 118/234 (50%), Gaps = 31/234 (13%)

Query: 1   MLEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV---VMQTVRDQIGQHVFTA-HRLDRP 56
           +  I Y+DE L+  +KP G +      DR    +   V+   + Q  Q  F A +RLDR 
Sbjct: 81  LFGIPYEDEHLLVADKP-GHMATIPSRDRPGGSLANGVLHYYKQQHLQATFHAVNRLDRG 139

Query: 57  TSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEA-VLDYPLVEELDKIADKF 115
           TSG+L++     A  LL++  +Q  +++ Y A+V G L E+A +++ P+    D+     
Sbjct: 140 TSGLLIVAKHRYAHDLLSRLQQQGGVKRCYKALVTGVLSEKAGIINAPI----DRKPGSI 195

Query: 116 AREDKGP--QPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
              + GP  + A+THY+    VE    T       + LV L+ +TGR HQ+R H A++ H
Sbjct: 196 IEREVGPGGKSAITHYK----VEAESKT-------HSLVSLQLETGRTHQIRVHFAYIGH 244

Query: 174 PIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTW 227
           P++GD  +GD  +         L    LH  +++LTHPFT E L +   L   W
Sbjct: 245 PLVGDGLYGDHGE--------ALAHQALHCDRVALTHPFTDEVLYVEKSLPKEW 290


>UniRef50_C0ZCK6 Pseudouridine synthase n=1 Tax=Brevibacillus brevis NBRC 100599
           RepID=C0ZCK6_BREBN
          Length = 302

 Score = 91.3 bits (225), Expect = 3e-17,   Method: Compositional matrix adjust.
 Identities = 74/227 (32%), Positives = 111/227 (48%), Gaps = 29/227 (12%)

Query: 3   EILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTV-----RDQIGQHVFTAHRLDRPT 57
           EILY+D+ L+ VNKP G L+H +  +R   V +   V     R  +   V   HRLD+ T
Sbjct: 87  EILYEDDHLLIVNKPVGLLLHPT--ERYHHVTLDHLVSGHFFRTGLEAKVRHVHRLDQDT 144

Query: 58  SGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADKFA 116
           SGV+L      A  LL +   +  I++ Y A V G +  E   ++ P+ +  D+      
Sbjct: 145 SGVVLYAKHPWASALLDEMLRERTIKRTYVAYVSGQMPKERGKINEPIGK--DRNHGTRR 202

Query: 117 REDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPII 176
           R      PA+THY+            R+ T     VE + +TGR HQ+R H +H+ HP++
Sbjct: 203 RVTPNGDPAITHYQ---------VKERFQTATK--VECQLETGRTHQIRVHFSHIGHPLL 251

Query: 177 GDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGL 223
           GD  +G  R+         ++R  LHA+ L   HPF GE + + A L
Sbjct: 252 GDELYGGKREL--------IKRQALHAAVLKFEHPFGGEVIEVTAPL 290


>UniRef50_A8F4Z7 Pseudouridine synthase n=2 Tax=Thermotogaceae RepID=A8F4Z7_THELT
          Length = 294

 Score = 91.3 bits (225), Expect = 3e-17,   Method: Compositional matrix adjust.
 Identities = 65/233 (27%), Positives = 105/233 (45%), Gaps = 44/233 (18%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTA---------HR 52
           L+ILY+D+ L+ +NK +G  +H S   R   ++         G H + A         HR
Sbjct: 86  LDILYEDDNLLILNKKAGITIHPSEKTRSTTLIQ--------GLHFYGAKKGFKPHLVHR 137

Query: 53  LDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIA 112
           LDR TSGVL++  + +  R L+  F    ++K Y  +V G +  +  +D PL        
Sbjct: 138 LDRDTSGVLVIAKNVKTARTLSHMFRNRLVKKEYITLVSGKIFGDGFIDKPL-------- 189

Query: 113 DKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLR 172
                       A+T Y+ L                  L+ +   TGR HQ+R+H A + 
Sbjct: 190 --------DGSEALTEYKVLENFR-----------DTSLLRVILHTGRTHQIRKHFALIG 230

Query: 173 HPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDD 225
           +P++GD  +GD + N    +   L+R  LH  ++S T+P     ++I A L D
Sbjct: 231 NPVVGDILYGDKKVNELFKKKHNLRRQFLHCIRISFTNPSEPGVISIKAPLPD 283


>UniRef50_D2RJC8 Pseudouridine synthase, RluA family n=2 Tax=Veillonellaceae
           RepID=D2RJC8_ACIFE
          Length = 294

 Score = 91.3 bits (225), Expect = 3e-17,   Method: Compositional matrix adjust.
 Identities = 71/224 (31%), Positives = 113/224 (50%), Gaps = 27/224 (12%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLD-RDEKVVVMQTVRDQIGQH--VFTAHRLDRPTS 58
           L +LY+DE L+ V+KP+G L+H +W   RD  V  +     + GQH  +   +RLDR T+
Sbjct: 77  LSLLYEDEDLLVVDKPAGMLIHPTWSGARDTLVQAVGGYFRRTGQHCGIHPLYRLDRDTT 136

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRG-WLMEEAVLDYPLVEELDKIADKFAR 117
           GVL++  S+ A   L +  +  QI + Y A+  G W + +  +++P+    + +     R
Sbjct: 137 GVLMVAKSAFAKHALTR--DHSQIYREYLAVCEGRWGIPQGRIEHPIGRVAEGVDRWTVR 194

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
            D   +PAVT YR L                + ++++   TGR HQ+R H AH  HP++G
Sbjct: 195 PDG--RPAVTEYRILEE-----------NQEWTVLKIHLLTGRTHQIRVHFAHEGHPLVG 241

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHA 221
           D  +G     + G     + R  LHA  +   HP TGE + + A
Sbjct: 242 DPLYG----TKDGR----IARQALHAWTVRFRHPRTGEEILLTA 277


>UniRef50_A4J479 Pseudouridine synthase n=1 Tax=Desulfotomaculum reducens MI-1
           RepID=A4J479_DESRM
          Length = 303

 Score = 91.3 bits (225), Expect = 3e-17,   Method: Compositional matrix adjust.
 Identities = 72/228 (31%), Positives = 112/228 (49%), Gaps = 29/228 (12%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKV---VVMQTVRDQIGQHVFTAHRLDRPTS 58
           L ILY+D  L+AVNKP G LVH    +    +   V+   ++          HRLDR TS
Sbjct: 84  LNILYEDAHLLAVNKPPGMLVHPLTNETSGTLANGVLYHWLQQGTIDRFRPVHRLDRNTS 143

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADKFAR 117
           G++L+  +    + L  Q +Q Q  +RY A+V+G +  E+ V+  P+  E       F +
Sbjct: 144 GIVLIARNPYVQQQLQIQMKQGQFVRRYLALVKGKVQPEQGVIQAPIALE----EGSFIK 199

Query: 118 EDKGP--QPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
               P  + A++HY+ L T             +  LV +E +TGR HQ+R H+AH+ HP+
Sbjct: 200 RMISPAGKEAISHYQVLRTF-----------NQASLVRVELETGRTHQVRVHMAHMGHPL 248

Query: 176 IGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGL 223
           +GDS +G    N        ++R  LH + L+  HP  G  + I   +
Sbjct: 249 LGDSLYGGDTSN--------IKRQALHCAYLAFNHPVQGSRIKISCSV 288


>UniRef50_C0Z877 Pseudouridine synthase n=1 Tax=Brevibacillus brevis NBRC 100599
           RepID=C0Z877_BREBN
          Length = 310

 Score = 90.9 bits (224), Expect = 3e-17,   Method: Compositional matrix adjust.
 Identities = 76/239 (31%), Positives = 115/239 (48%), Gaps = 25/239 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQH--VFTAHRLDRPTSG 59
           ++ILY+D+ L+  NKP+G +VH    + D  V  +  V    G+   V   HRLD+ TSG
Sbjct: 94  IDILYEDDHLLIANKPAGMMVHPIKQETDTLVHALAAVLAARGEQTSVHPVHRLDKDTSG 153

Query: 60  VLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEA-VLDYPLVEELDKIADKFARE 118
            +L+  SS   +L  +   +  I + Y A+  G L E A  +D P+  +      +   E
Sbjct: 154 AILVAKSSYGHQLADRLLREGGIHREYLAVASGVLSEGAGTIDAPIGRDARHPTKRRVVE 213

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
                PA+THY    T E              L  +  +TGR HQ+R H AH+ HP+ GD
Sbjct: 214 SG--DPAITHYEVQQTSE-----------EMTLARVWLETGRTHQIRVHFAHIGHPLAGD 260

Query: 179 SKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWR 237
           + +G       GA    L+R  LHAS+LS  HP   + + + A +  + M+ L Q  +R
Sbjct: 261 TMYG-------GARGL-LRRQALHASKLSFLHPLLEKEIVVEAPI-PSDMKRLMQAEFR 310


>UniRef50_B1MWE1 Pseudouridine synthase n=3 Tax=Leuconostoc RepID=B1MWE1_LEUCK
          Length = 306

 Score = 90.9 bits (224), Expect = 4e-17,   Method: Compositional matrix adjust.
 Identities = 71/242 (29%), Positives = 119/242 (49%), Gaps = 36/242 (14%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTA---------HR 52
           L+I+++++ LV VNKP+G  +H       + ++          +H+++A         HR
Sbjct: 87  LDIIFENDDLVVVNKPAGMKMHPHSPSETDTLLNFLAANFS-KRHLYSAGAIAKPYMVHR 145

Query: 53  LDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEA-VLDYPLVEELDKI 111
           +DR TSG +++  +     +L +  ++  IQ+ Y A V+G L++ +  +D P+  ++ K 
Sbjct: 146 IDRETSGAVIVAKNPVVVPILNRMLKEKVIQRTYLAWVQGILLKNSGTIDRPIGRDISK- 204

Query: 112 ADKFAREDKGPQP--AVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLA 169
              F R+  G Q   A TH+  + TV            +  L+ L+  TGR HQ+R HLA
Sbjct: 205 --PFQRQVNGVQAQHAKTHWFKIHTV-----------FQNTLLRLQLDTGRMHQIRVHLA 251

Query: 170 HLRHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQ 229
            + HPI+GDS +G         +    QR+MLHA  L+L  PF G    I   L   + +
Sbjct: 252 SINHPIVGDSLYG---------QRLNQQRMMLHAMSLTLPLPFDGPKRIITTSLPSDFPK 302

Query: 230 AL 231
            L
Sbjct: 303 QL 304


>UniRef50_A0L7F8 Pseudouridine synthase n=6 Tax=Proteobacteria RepID=A0L7F8_MAGSM
          Length = 255

 Score = 90.9 bits (224), Expect = 4e-17,   Method: Compositional matrix adjust.
 Identities = 73/235 (31%), Positives = 114/235 (48%), Gaps = 18/235 (7%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLM 63
           +LY+D  L+ +NKP+G  VH           +   +R  + +    AHRLDR TSG L++
Sbjct: 15  LLYRDGLLLIINKPAGIPVHAGPGGGANLEALFGGLRFGLPKAPALAHRLDRDTSGCLVL 74

Query: 64  GLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADKFAREDKGP 122
           G  ++A   L + F Q ++QK Y A+V+G   + +  +D+PL         K +   +G 
Sbjct: 75  GRHAKALSKLGKLFSQGKVQKTYWAVVQGGPPQAQGSMDFPLY--------KISTAQQGW 126

Query: 123 QPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHG 182
           +  V   +G +++ +    GR  T  +  +EL PKTGR HQ+R H AH+  PI GD ++G
Sbjct: 127 RMVVDPEQGKSSLTLYRVLGRSATHSW--LELTPKTGRTHQIRVHCAHVGLPIEGDLQYG 184

Query: 183 DLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWR 237
                   A       L LHA Q+ L    +  P+ + A         L Q G+R
Sbjct: 185 -------AAPSEPQLTLHLHARQIILPISASKAPINVSAPPPRAMRGLLEQCGYR 232


>UniRef50_C1TRW2 Pseudouridine synthase n=1 Tax=Dethiosulfovibrio peptidovorans DSM
           11002 RepID=C1TRW2_9BACT
          Length = 305

 Score = 90.9 bits (224), Expect = 4e-17,   Method: Compositional matrix adjust.
 Identities = 71/207 (34%), Positives = 109/207 (52%), Gaps = 20/207 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           L  +Y+DE L  V+KP+G L        D   VV +             +RLDR TSG++
Sbjct: 79  LVTVYRDESLWVVSKPAGLLSQPDKKGGDS--VVTRAFLPGSSFQPQAVNRLDRNTSGIM 136

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKG 121
           ++ L+ E+ R L+ ++   +++K Y A+V G L EE  +D PL +  D  ++K   + KG
Sbjct: 137 VLALTGESLRDLSSRWRDGEMEKVYLALVVGDLPEEGSIDAPLSK--DGSSNKVFVDSKG 194

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
            Q ++T YR LA+       G        L+     TGR HQ+R H++H+ HP++GD K+
Sbjct: 195 -QSSLTLYRRLAS------GGGLSLCLVTLI-----TGRSHQIRVHMSHIGHPVLGDVKY 242

Query: 182 GDLRQNRSGAEHFGLQRLMLHASQLSL 208
           GD   N  G +  G +R MLHA  +S 
Sbjct: 243 GDRALN--GVK--GAKRPMLHAFSVSF 265


>UniRef50_B9MS57 Pseudouridine synthase n=1 Tax=Anaerocellum thermophilum DSM 6725
           RepID=B9MS57_ANATD
          Length = 293

 Score = 90.9 bits (224), Expect = 4e-17,   Method: Compositional matrix adjust.
 Identities = 60/212 (28%), Positives = 108/212 (50%), Gaps = 28/212 (13%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRS---WLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTS 58
           ++ILY+D + + VNKPSG   H S   + D     V        +  H+   +RLD+ TS
Sbjct: 77  IDILYEDNFFLFVNKPSGLPSHPSKGHYFDTIANYVEYYLNSKNLTSHI--INRLDKDTS 134

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEA-VLDYPLVEELDKIADKFAR 117
           G+++   +S    +++ +FE+ ++ K Y AIV G L +++ +++ P+    D I  +  +
Sbjct: 135 GIVVFAKNSYFHSIVSYEFEKRRVDKTYIAIVHGILTKKSGLIEKPIKRSDDGIKREIHQ 194

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
           +      A T+Y  + + E            + +++L+P TGR HQLR HL+ + HPI+G
Sbjct: 195 DGSF---ASTYYEVIDSFE-----------NFSVLKLKPITGRTHQLRVHLSSIGHPIVG 240

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLT 209
           D  +G+ +   +         L+LHA  +S  
Sbjct: 241 DYIYGEEKTQNTP--------LLLHAYSISFN 264


>UniRef50_C8WV14 Pseudouridine synthase n=2 Tax=Alicyclobacillus acidocaldarius
           RepID=C8WV14_ALIAD
          Length = 314

 Score = 90.9 bits (224), Expect = 4e-17,   Method: Compositional matrix adjust.
 Identities = 67/237 (28%), Positives = 110/237 (46%), Gaps = 19/237 (8%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ-HVFTAHRLDRPTSGV 60
           + +LY D  L+ V+KP   LVHR   D       +Q + ++ G    +  HRLDR T+G 
Sbjct: 85  VRVLYNDPSLLVVDKPENLLVHRDGSDAPTLDACVQRLLNEEGAGRAYHVHRLDRGTTGC 144

Query: 61  LLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDK 120
           +L        R +  +    ++++ Y AI  G  +   V+  P+    D+      R  +
Sbjct: 145 VLYAKHGLMLRAMDAELAAGRVRRTYLAIASGTRIRPGVMSAPIGR--DRHVSGRYRVSR 202

Query: 121 GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSK 180
             + A TH   L   +   A       R+ LV L  +TGR+HQ+R HL+ +  P++GD+ 
Sbjct: 203 TGKVARTHVEVLDEADQGGA-------RWTLVRLRLETGRRHQIRVHLSAMGAPVVGDTL 255

Query: 181 HGDLRQNRSGAEHFGLQ--RLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFG 235
           +G       G  H  L   ++ LHA++L   HP+ GE + + A L   W +  +  G
Sbjct: 256 YG-------GTPHPALAPGQIALHAARLQFCHPYAGEDVEVRAPLPRAWEKLAADVG 305


>UniRef50_B8GX34 Pseudouridine synthase n=7 Tax=Caulobacteraceae RepID=B8GX34_CAUCN
          Length = 331

 Score = 90.9 bits (224), Expect = 4e-17,   Method: Compositional matrix adjust.
 Identities = 77/239 (32%), Positives = 113/239 (47%), Gaps = 24/239 (10%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLM 63
           +LY+DE ++A+NKP+G  V            ++    + + +     HRLDR TSGVLL+
Sbjct: 93  VLYEDEEVLALNKPAGLAVQGGTKTTKHIDKLLSAWGEGVDRPRLV-HRLDRDTSGVLLL 151

Query: 64  GLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADK-----FAR 117
           G +  A   L+  F + + QK Y AIV G     E V++  L +    + D+        
Sbjct: 152 GKTPSAAARLSGAFAKRKAQKTYWAIVAGNPHPTEGVMELHLAKR--GVGDRELVVPAQP 209

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
           +D   QPA T +  ++              R   + L P TGR HQLR H+  + HPI+G
Sbjct: 210 KDPDAQPAETEFVTISRA----------GPRVTWMALRPHTGRTHQLRAHMKAMGHPILG 259

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGW 236
           D K+GD    +S     GL +L LHA  + L HP  G  L I A L     +   +FG+
Sbjct: 260 DPKYGD---EKSAPLSEGL-KLQLHARSILLPHPSAGM-LHIEAPLSPEMKEGFRKFGF 313


>UniRef50_Q0VQA6 Pseudouridine synthase n=7 Tax=Gammaproteobacteria
           RepID=Q0VQA6_ALCBS
          Length = 229

 Score = 90.9 bits (224), Expect = 4e-17,   Method: Compositional matrix adjust.
 Identities = 76/214 (35%), Positives = 112/214 (52%), Gaps = 25/214 (11%)

Query: 5   LYQDEWLVAVNKPSGWLV--HRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLL 62
           +Y+DE L+ +NKP+  L    R+  ++D  +  +Q    Q    +   HRLD  TSG+++
Sbjct: 26  IYRDEHLLLINKPAYLLSVPGRAPENKDCAIRRLQ----QRYPDIRLVHRLDLDTSGIMV 81

Query: 63  MGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEA-VLDYPLVEELDKIADKFAREDKG 121
            GL++ A   L++ F+   ++KRY AIV G + + A  +D PL+ +  K   +    + G
Sbjct: 82  FGLTAFAQSKLSRLFQLRTVKKRYQAIVHGLVEKNAGSIDLPLIADWPKRPLQKVCHETG 141

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
            + A+THYR L   E  +   R   TR   + L P TGR HQLR H   L HPIIG   +
Sbjct: 142 -KNALTHYRVL---ERDIPGNR---TR---LALSPVTGRSHQLRIHCRELGHPIIGCDMY 191

Query: 182 GDLRQNRSGAEHFGLQ-RLMLHASQLSLTHPFTG 214
                  + AE   L  RL+LHA  L+  HP TG
Sbjct: 192 -------APAEIEALSPRLLLHAEWLAFNHPLTG 218


>UniRef50_Q2CAH0 Pseudouridine synthase n=3 Tax=Proteobacteria RepID=Q2CAH0_9RHOB
          Length = 215

 Score = 90.9 bits (224), Expect = 4e-17,   Method: Compositional matrix adjust.
 Identities = 77/224 (34%), Positives = 107/224 (47%), Gaps = 28/224 (12%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG-QHVFTAHRLDRPTSGV 60
           L +L++D  +V V+KP+G L   S   + E +      R Q         HRLDR TSGV
Sbjct: 12  LAVLHEDHEVVLVDKPAGLL---SVPGKGEHLADCLLARVQAAFPTALLVHRLDRDTSGV 68

Query: 61  LLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADKFARED 119
           ++  L+  A R L  QFE+ Q +K Y A V G + ++   +D PL+ +      +    +
Sbjct: 69  MIFALTPHAQRHLGLQFEKRQTRKTYVARVAGRIADKTGTVDLPLIVDWPNRPKQMVDHE 128

Query: 120 KGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDS 179
            G +PAVT +R        V       TR   V L PKTGR HQLR H+  L HPI+GD 
Sbjct: 129 NG-KPAVTDWR--------VVRASDAETR---VRLFPKTGRSHQLRVHMLALGHPILGDP 176

Query: 180 KH--GDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHA 221
            +  G  R +          R+MLH+  L   HP  G  + I A
Sbjct: 177 FYAEGPARAH---------PRMMLHSETLQFRHPDGGRGMRITA 211


>UniRef50_D2QLU1 Pseudouridine synthase n=53 Tax=Bacteroidetes RepID=D2QLU1_9SPHI
          Length = 248

 Score = 90.5 bits (223), Expect = 5e-17,   Method: Compositional matrix adjust.
 Identities = 73/247 (29%), Positives = 120/247 (48%), Gaps = 38/247 (15%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ------HVFT--AHRL 53
            +++Y+D  L+ VNK  G LV     DR   + ++  ++D I +       VF    HRL
Sbjct: 6   FQVVYEDNHLLIVNKDPGILVQG---DRTGDITLLDVLKDYIKEKYNKPGEVFLGLVHRL 62

Query: 54  DRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEA--VLDYPLVEELDKI 111
           DRP SG+++   +S+A   + + F + Q+QK Y A+VR    +++  ++++ + +E    
Sbjct: 63  DRPVSGLVVFARTSKALERMNEIFRKRQVQKTYWAVVRRKPPKDSDKLVNWLIKDEQKNQ 122

Query: 112 ADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHL 171
              +  E    Q A   YR L  +             + L+E+ P TGR HQ+R  LAH+
Sbjct: 123 VTVYDYEVPKSQKAELSYRVLGKI-----------NEHYLLEVNPITGRPHQIRSQLAHM 171

Query: 172 RHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFT-----GEPLTIHAGL--D 224
             PI GD K+G    +R+ A+    +++ LHA +L   HP         P+   AGL  D
Sbjct: 172 GCPIRGDIKYG---YDRAVAD----KKIYLHARRLYFIHPIKQAGAEDRPIICKAGLPND 224

Query: 225 DTWMQAL 231
             W + L
Sbjct: 225 PFWEEFL 231


>UniRef50_Q38Y05 Pseudouridine synthase, 23S-rRNA-specific n=1 Tax=Lactobacillus
           sakei subsp. sakei 23K RepID=Q38Y05_LACSS
          Length = 296

 Score = 90.5 bits (223), Expect = 5e-17,   Method: Compositional matrix adjust.
 Identities = 73/237 (30%), Positives = 112/237 (47%), Gaps = 29/237 (12%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVR---DQIGQHVFTAHRLDRPTS 58
             +L++ + L+ VNKP+G   H +     E   +M  V     Q G+  +  HR+D  TS
Sbjct: 83  FSVLFESDDLLIVNKPAGIKTHPNR--PGENGTLMNQVAFYLAQQGKKAYMVHRIDEATS 140

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIV---RGWLMEEAVLDYPLVEELDKIADKF 115
           G LL+G +     +L +Q  Q ++ ++Y AIV   +  L E A ++ P+  + +    + 
Sbjct: 141 GTLLIGKTPIVIGILNRQLSQKKMARQYIAIVDDPKHELAEHATINSPIGVDPENDRQRC 200

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
                G   A+THYR L+         R   T    V+LE  TGR HQ+R HLA + HPI
Sbjct: 201 VDYING-LSAITHYRVLS---------RKGATAVLAVDLE--TGRTHQIRVHLASIGHPI 248

Query: 176 IGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALS 232
           +GD  +                RL+LH   L  T P+T +P T+ A + D +   LS
Sbjct: 249 LGDPLYNPTDTT---------PRLLLHGQTLRYTEPYTDQPRTVTAPVPDAFEPYLS 296


>UniRef50_P59831 Ribosomal large subunit pseudouridine synthase A n=20
           Tax=Proteobacteria RepID=RLUA_HAEDU
          Length = 222

 Score = 90.5 bits (223), Expect = 5e-17,   Method: Compositional matrix adjust.
 Identities = 75/226 (33%), Positives = 111/226 (49%), Gaps = 25/226 (11%)

Query: 1   MLEILYQDEWLVAVNKPSGWLVHRSWLDRDEKV-VVMQTVRDQIGQHVFTAHRLDRPTSG 59
            LE +Y+D  +V +NKPSG L      +R E    VM  V+ + G     AHRLD  TSG
Sbjct: 13  FLEEVYRDNHIVVINKPSGLLSVPG--NRPEYYDSVMTRVQQRYG-FAEPAHRLDMATSG 69

Query: 60  VLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEA----VLDYPLVEELDKIADKF 115
           ++L+ LS  A + L +QF   + +K Y A++ G L +       +++PL+ + +    + 
Sbjct: 70  IILLALSKVAEKELKRQFRDREPKKHYIALLWGKLGDRVGQTGEINFPLICDWENRPRQK 129

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
              ++G + A THY  L  +          TTR   V+  P TGR HQLR H   L HPI
Sbjct: 130 ICYERG-KKATTHYEVLEHLAN-------NTTR---VKFTPITGRSHQLRVHSLALGHPI 178

Query: 176 IGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHA 221
           IGD  + +              RL LHA  L++ HP + E +T + 
Sbjct: 179 IGDKFYANPLAKSLAP------RLCLHAESLTIAHPISAELMTFNT 218


>UniRef50_B8J173 Pseudouridine synthase, RluA family n=2 Tax=Desulfovibrio
           RepID=B8J173_DESDA
          Length = 525

 Score = 90.5 bits (223), Expect = 6e-17,   Method: Compositional matrix adjust.
 Identities = 74/221 (33%), Positives = 103/221 (46%), Gaps = 23/221 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV------VMQTVRDQIGQHVFTAHRLDR 55
           LE+L+QD+ LV  NKP+G  VH      ++ +V        Q  R + GQ     HRLD+
Sbjct: 80  LELLWQDDHLVVCNKPAGLTVHPCPSCPEQTLVQRLLGRFPQLSRLE-GQRPGIVHRLDK 138

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVE-ELDKIADK 114
            TSG+L++ L+      LA  F + Q+ K Y A+V G    E     PL      KI   
Sbjct: 139 DTSGLLVVALTEADCLALAAAFAERQVHKEYLALVSGLPPLEGQCREPLGRHPTAKIKMA 198

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
              ED+G + A T +R L   +              L+ +   TGR HQ+R H+ HL +P
Sbjct: 199 VVPEDQGGRNAFTEWRRLWNTD---------DGSVSLLAVRIHTGRTHQIRVHMTHLGYP 249

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGE 215
           ++GD      R     A      R MLHA +L  THP +GE
Sbjct: 250 LLGD------RLYAPKAVQNMAPRQMLHAWRLGFTHPASGE 284


>UniRef50_C7GZU4 Pseudouridine synthase n=1 Tax=Eubacterium saphenum ATCC 49989
           RepID=C7GZU4_9FIRM
          Length = 331

 Score = 90.5 bits (223), Expect = 6e-17,   Method: Compositional matrix adjust.
 Identities = 65/233 (27%), Positives = 109/233 (46%), Gaps = 36/233 (15%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHV-------------FTA 50
           ILY+D++++ V+KP+G L H       E      T+ D+I ++                 
Sbjct: 108 ILYEDDYIIVVDKPAGLLTHAKGDKSCE-----CTLSDKILEYTEGSLANGSGANRPGVV 162

Query: 51  HRLDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDK 110
           HRLDR T GV++M  +  A + L + FE+ ++ K Y AIV   ++ ++ +    +E   K
Sbjct: 163 HRLDRGTCGVMVMAKTDTALKHLTEAFEKQEVSKEYEAIVYDNIVRDSGVITAKIERNKK 222

Query: 111 IADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAH 170
              K +  D+G +         A  E  V   R+    Y  V L  K+GR HQ+R H+ +
Sbjct: 223 NRLKMSAGDEGRE---------AHTEFKVIE-RFGKFTY--VSLVIKSGRTHQIRVHMNY 270

Query: 171 LRHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGL 223
           + HP++GD  +G  +      + F L   ML + ++   HP T E +   A +
Sbjct: 271 IHHPVLGDMLYGKRK------DKFNLMWPMLRSKKIGFLHPITSEKMEFTAAM 317


>UniRef50_UPI00016C4782 RNA pseudouridylate synthase n=1 Tax=Gemmata obscuriglobus UQM 2246
           RepID=UPI00016C4782
          Length = 275

 Score = 90.5 bits (223), Expect = 6e-17,   Method: Compositional matrix adjust.
 Identities = 84/230 (36%), Positives = 113/230 (49%), Gaps = 34/230 (14%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQT--VRDQIGQHVFTAHRLDRPTSG 59
           LEI+++D  LV ++KPSG L   +  ++ +   V  +  +R +     F  HRLDR TSG
Sbjct: 62  LEIVHEDAHLVVIDKPSGLLTVATESEKLDTAFVRLSDYLRARNAGRPFVVHRLDRDTSG 121

Query: 60  VLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGW--LMEEAVLDYPLVEELDKIADKFAR 117
           +LL   S+E    L   +E+  + K Y A+V G     E  V +Y L E  D       R
Sbjct: 122 LLLFARSAEVRDQLQGNWEE--LTKTYLAVVEGRPESSEGGVENY-LTEGRD------LR 172

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPT--TR--YGLVELEPKTGRKHQLRRHLAHLRH 173
               P+P     R         A  RY    TR  Y LVE+E +TGRKHQ+R HLA L  
Sbjct: 173 VRASPRPGPDGKR---------AASRYTVRQTRGGYSLVEVEIETGRKHQIRVHLAGLGC 223

Query: 174 PIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGL 223
           P+ GD  +        GA    ++RL LHA +LS  HPFT E L + A L
Sbjct: 224 PVAGDKMY--------GATTDPVRRLGLHAWRLSFDHPFTLERLELEAPL 265


Searching..................................................done


Results from round 2


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value
Sequences used in model and found again:

UniRef50_Q47417 tRNA pseudouridine synthase C n=252 Tax=cellular...   360   3e-98
UniRef50_Q8DBG5 tRNA pseudouridine synthase C n=54 Tax=Gammaprot...   316   6e-85
UniRef50_B8CQ92 Pseudouridine synthase n=1 Tax=Shewanella piezot...   310   3e-83
UniRef50_Q30SZ1 Pseudouridine synthase n=2 Tax=Proteobacteria Re...   304   2e-81
UniRef50_Q15QZ8 Pseudouridine synthase n=5 Tax=Bacteria RepID=Q1...   299   8e-80
UniRef50_Q39Z12 Pseudouridine synthase n=3 Tax=Proteobacteria Re...   298   1e-79
UniRef50_C5TPY8 Pseudouridine synthase n=6 Tax=Proteobacteria Re...   297   2e-79
UniRef50_B0TGQ0 Pseudouridine synthase n=44 Tax=Bacteria RepID=B...   297   2e-79
UniRef50_B9Y836 Pseudouridine synthase n=3 Tax=Firmicutes RepID=...   296   4e-79
UniRef50_Q3ABZ7 Pseudouridine synthase n=2 Tax=Bacteria RepID=Q3...   294   2e-78
UniRef50_C6XFD0 Pseudouridine synthase n=1 Tax=Candidatus Liberi...   293   3e-78
UniRef50_C4KBT4 Transaldolase n=2 Tax=Proteobacteria RepID=C4KBT...   293   6e-78
UniRef50_C0Q9S8 TruC n=1 Tax=Desulfobacterium autotrophicum HRM2...   291   1e-77
UniRef50_A3HSB5 Pseudouridine synthase n=1 Tax=Algoriphagus sp. ...   290   4e-77
UniRef50_C7NAV5 Pseudouridine synthase n=5 Tax=Fusobacteriaceae ...   288   1e-76
UniRef50_Q6AJM1 Pseudouridine synthase n=1 Tax=Desulfotalea psyc...   288   1e-76
UniRef50_C8PZW5 Pseudouridine synthase n=1 Tax=Enhydrobacter aer...   286   4e-76
UniRef50_C4FYR8 Pseudouridine synthase n=1 Tax=Abiotrophia defec...   286   6e-76
UniRef50_B2UL66 Pseudouridine synthase n=2 Tax=Verrucomicrobiace...   286   6e-76
UniRef50_Q45826 Uncharacterized RNA pseudouridine synthase Caur_...   286   6e-76
UniRef50_A1K5H7 Pseudouridine synthase n=5 Tax=Proteobacteria Re...   284   1e-75
UniRef50_UPI0001AEC02F pseudouridylate synthase, 23S RNA-specifi...   284   2e-75
UniRef50_Q82WZ5 Ribosomal large subunit pseudouridine synthase D...   284   2e-75
UniRef50_A9BFW4 Pseudouridine synthase n=8 Tax=Thermotogaceae Re...   284   2e-75
UniRef50_P50513 Ribosomal large subunit pseudouridine synthase D...   284   2e-75
UniRef50_C9KPZ8 Pseudouridine synthase n=1 Tax=Mitsuokella multa...   283   3e-75
UniRef50_Q31IZ8 Pseudouridine synthase n=2 Tax=Proteobacteria Re...   283   4e-75
UniRef50_A7NB61 Pseudouridine synthase n=18 Tax=Francisella RepI...   283   6e-75
UniRef50_A3EQJ0 Pseudouridine synthase n=1 Tax=Leptospirillum ru...   282   7e-75
UniRef50_A9IQ66 Pseudouridine synthase n=5 Tax=Bacteria RepID=A9...   282   9e-75
UniRef50_A7HM17 Pseudouridine synthase n=2 Tax=Thermotogaceae Re...   281   1e-74
UniRef50_Q9JVB6 Ribosomal large subunit pseudouridine synthase D...   280   2e-74
UniRef50_A4BJ00 Pseudouridine synthase n=1 Tax=Reinekea blandens...   279   4e-74
UniRef50_B8FT16 Pseudouridine synthase n=70 Tax=Bacteria RepID=B...   279   4e-74
UniRef50_A1U2H1 Pseudouridine synthase n=1 Tax=Marinobacter aqua...   279   5e-74
UniRef50_B9JRD0 Pseudouridine synthase n=1 Tax=Agrobacterium vit...   278   1e-73
UniRef50_Q8XYX8 Ribosomal large subunit pseudouridine synthase D...   278   1e-73
UniRef50_A6VXE8 Pseudouridine synthase n=2 Tax=Marinomonas RepID...   278   1e-73
UniRef50_C8QZ10 Pseudouridine synthase n=1 Tax=Desulfurivibrio a...   278   2e-73
UniRef50_Q1N5G6 Pseudouridine synthase n=1 Tax=Bermanella marisr...   278   2e-73
UniRef50_B8FLB4 Pseudouridine synthase n=2 Tax=Bacteria RepID=B8...   277   2e-73
UniRef50_B2A2J2 Pseudouridine synthase n=1 Tax=Natranaerobius th...   277   2e-73
UniRef50_B8CWM0 Pseudouridine synthase n=1 Tax=Halothermothrix o...   276   5e-73
UniRef50_B4RVP9 Pseudouridine synthase n=1 Tax=Alteromonas macle...   276   5e-73
UniRef50_D2L0S2 Pseudouridine synthase, RluA family n=1 Tax=Desu...   276   6e-73
UniRef50_Q1MQ60 Pseudouridylate synthases, 23S RNA-specific n=1 ...   275   9e-73
UniRef50_B6AN83 Pseudouridine synthase n=2 Tax=Leptospirillum Re...   275   1e-72
UniRef50_D2QPA6 Pseudouridine synthase n=1 Tax=Spirosoma lingual...   274   2e-72
UniRef50_A7HV45 Pseudouridine synthase n=56 Tax=Alphaproteobacte...   274   2e-72
UniRef50_A9BZ16 Pseudouridine synthase n=9 Tax=Burkholderiales R...   274   2e-72
UniRef50_B1I3F8 Pseudouridine synthase n=2 Tax=Bacteria RepID=B1...   274   2e-72
UniRef50_C1F7V3 Pseudouridine synthase n=1 Tax=Acidobacterium ca...   274   2e-72
UniRef50_B9L028 Pseudouridine synthase n=2 Tax=Thermomicrobia (c...   273   5e-72
UniRef50_D1ANU4 Pseudouridine synthase n=14 Tax=Fusobacteriaceae...   273   6e-72
UniRef50_B5JL25 Pseudouridine synthase n=1 Tax=Verrucomicrobiae ...   273   6e-72
UniRef50_Q2LWV4 Pseudouridine synthase n=1 Tax=Syntrophus acidit...   272   8e-72
UniRef50_A6DUC9 Pseudouridine synthase n=1 Tax=Lentisphaera aran...   272   8e-72
UniRef50_Q1ILA4 Pseudouridine synthase n=1 Tax=Candidatus Koriba...   271   1e-71
UniRef50_Q49WX8 Pseudouridine synthase n=1 Tax=Staphylococcus sa...   271   2e-71
UniRef50_C8NEP8 Pseudouridine synthase n=1 Tax=Granulicatella ad...   271   2e-71
UniRef50_B5YKV0 Pseudouridine synthase n=1 Tax=Thermodesulfovibr...   271   2e-71
UniRef50_A3M2Y1 Pseudouridine synthase n=18 Tax=Gammaproteobacte...   271   2e-71
UniRef50_A9BMW0 Pseudouridine synthase n=10 Tax=Comamonadaceae R...   270   3e-71
UniRef50_P74346 Uncharacterized RNA pseudouridine synthase slr16...   270   3e-71
UniRef50_C4FWV7 Pseudouridine synthase n=2 Tax=Firmicutes RepID=...   270   3e-71
UniRef50_A6C0W7 Pseudouridine synthase n=1 Tax=Planctomyces mari...   270   4e-71
UniRef50_A5WFS2 Pseudouridine synthase n=3 Tax=Psychrobacter Rep...   269   4e-71
UniRef50_Q3A0C2 Pseudouridine synthase n=13 Tax=Bacteria RepID=Q...   269   6e-71
UniRef50_C8PVB8 Pseudouridine synthase n=2 Tax=Moraxellaceae Rep...   269   6e-71
UniRef50_D2BIX0 Pseudouridine synthase n=5 Tax=Dehalococcoides R...   269   6e-71
UniRef50_Q2W2D5 Pseudouridine synthase n=39 Tax=Bacteria RepID=Q...   269   6e-71
UniRef50_D1VS73 Pseudouridine synthase n=1 Tax=Peptoniphilus lac...   269   7e-71
UniRef50_C6VVP1 Pseudouridine synthase n=4 Tax=Bacteroidetes Rep...   269   8e-71
UniRef50_B8E0R4 Pseudouridine synthase n=1 Tax=Dictyoglomus turg...   268   1e-70
UniRef50_Q3AVX8 Pseudouridine synthase n=40 Tax=cellular organis...   268   2e-70
UniRef50_C4XSN0 Ribosomal large subunit pseudouridine synthase D...   268   2e-70
UniRef50_C6BSG2 Pseudouridine synthase, RluA family n=1 Tax=Desu...   267   3e-70
UniRef50_Q87AR7 Ribosomal large subunit pseudouridine synthase D...   267   3e-70
UniRef50_C9LM35 Pseudouridine synthase n=1 Tax=Dialister invisus...   267   3e-70
UniRef50_A5EX53 Pseudouridine synthase n=1 Tax=Dichelobacter nod...   267   4e-70
UniRef50_C6WV38 Pseudouridine synthase n=3 Tax=Proteobacteria Re...   266   4e-70
UniRef50_A0L9J0 Pseudouridine synthase n=1 Tax=Magnetococcus sp....   266   4e-70
UniRef50_A8GQ59 Pseudouridine synthase n=15 Tax=Rickettsia RepID...   266   4e-70
UniRef50_C0BNA6 Pseudouridine synthase n=7 Tax=Bacteroidetes Rep...   266   5e-70
UniRef50_Q0BWH2 Pseudouridine synthase n=3 Tax=Alphaproteobacter...   266   6e-70
UniRef50_B8J173 Pseudouridine synthase, RluA family n=2 Tax=Desu...   266   7e-70
UniRef50_C5VRN0 Pseudouridine synthase n=1 Tax=Clostridium botul...   266   7e-70
UniRef50_C0ZH07 Pseudouridine synthase n=1 Tax=Brevibacillus bre...   265   1e-69
UniRef50_C8X1I9 Pseudouridine synthase, RluA family n=1 Tax=Desu...   265   1e-69
UniRef50_A5GW76 Pseudouridine synthase n=1 Tax=Synechococcus sp....   265   1e-69
UniRef50_D1PCC3 Pseudouridine synthase n=1 Tax=Prevotella copri ...   265   1e-69
UniRef50_D0RPR1 Pseudouridine synthase n=1 Tax=alpha proteobacte...   264   1e-69
UniRef50_D0KVM5 Pseudouridine synthase n=11 Tax=Proteobacteria R...   264   2e-69
UniRef50_O50310 Uncharacterized RNA pseudouridine synthase Cpar_...   264   2e-69
UniRef50_B0VJ94 Pseudouridine synthase n=1 Tax=Candidatus Cloaca...   263   3e-69
UniRef50_C6JBH1 Pseudouridine synthase n=1 Tax=Ruminococcus sp. ...   263   3e-69
UniRef50_Q8ZQ16 Ribosomal large subunit pseudouridine synthase C...   263   3e-69
UniRef50_C7RM94 Pseudouridine synthase n=11 Tax=Proteobacteria R...   263   7e-69
UniRef50_Q5QZ45 Pseudouridine synthase n=2 Tax=Gammaproteobacter...   262   9e-69
UniRef50_C1ZGS9 Pseudouridine synthase n=1 Tax=Planctomyces limn...   262   1e-68
UniRef50_Q1J0S8 Pseudouridine synthase n=7 Tax=Deinococci RepID=...   262   1e-68
UniRef50_Q2SS88 Pseudouridine synthase n=4 Tax=Mollicutes RepID=...   262   1e-68
UniRef50_D1BAB3 Pseudouridine synthase n=1 Tax=Thermanaerovibrio...   261   1e-68
UniRef50_B8GZR6 Pseudouridine synthase n=2 Tax=Caulobacter vibri...   261   1e-68
UniRef50_A1AW00 Pseudouridine synthase n=2 Tax=sulfur-oxidizing ...   261   2e-68
UniRef50_A0Q1S9 Pseudouridine synthase n=32 Tax=Clostridium RepI...   261   2e-68
UniRef50_P54604 Uncharacterized RNA pseudouridine synthase yhcT ...   260   3e-68
UniRef50_A9NGF1 Pseudouridine synthase n=1 Tax=Acholeplasma laid...   260   3e-68
UniRef50_D1N7N8 Pseudouridine synthase, RluA family n=1 Tax=Vict...   260   3e-68
UniRef50_Q8K9E9 Ribosomal large subunit pseudouridine synthase D...   260   3e-68
UniRef50_Q13E92 Pseudouridine synthase n=28 Tax=Alphaproteobacte...   260   3e-68
UniRef50_P65834 Ribosomal large subunit pseudouridine synthase D...   260   4e-68
UniRef50_Q126H9 Pseudouridine synthase n=1 Tax=Polaromonas sp. J...   259   4e-68
UniRef50_A0L8J2 Pseudouridine synthase n=1 Tax=Magnetococcus sp....   259   5e-68
UniRef50_B7GAM3 Predicted protein (Fragment) n=1 Tax=Phaeodactyl...   259   6e-68
UniRef50_B9YI75 Pseudouridine synthase, RluA family n=1 Tax='Nos...   259   6e-68
UniRef50_C7LP91 Pseudouridine synthase n=1 Tax=Desulfomicrobium ...   259   7e-68
UniRef50_B0K860 Pseudouridine synthase n=11 Tax=Thermoanaerobact...   259   8e-68
UniRef50_Q1QTG8 Pseudouridine synthase n=2 Tax=Gammaproteobacter...   259   8e-68
UniRef50_Q03WF6 Pseudouridine synthase n=9 Tax=Firmicutes RepID=...   259   9e-68
UniRef50_Q9KQH0 Ribosomal large subunit pseudouridine synthase C...   258   1e-67
UniRef50_Q4FN11 Pseudouridine synthase n=4 Tax=Bacteria RepID=Q4...   258   1e-67
UniRef50_D1Y3Y9 Pseudouridine synthase n=1 Tax=Pyramidobacter pi...   258   1e-67
UniRef50_D0J9U5 Pseudouridine synthase n=2 Tax=Blattabacterium R...   258   2e-67
UniRef50_Q89AH2 Ribosomal large subunit pseudouridine synthase C...   257   2e-67
UniRef50_C7LWM1 Pseudouridine synthase, RluA family n=1 Tax=Desu...   257   3e-67
UniRef50_C6J6E3 Pseudouridine synthase n=2 Tax=Bacillales RepID=...   257   3e-67
UniRef50_B0RLZ1 Pseudouridine synthase n=13 Tax=Xanthomonadaceae...   257   3e-67
UniRef50_C6XNC0 Pseudouridine synthase n=1 Tax=Hirschia baltica ...   257   4e-67
UniRef50_A8ZXZ8 Pseudouridine synthase n=1 Tax=Desulfococcus ole...   256   4e-67
UniRef50_D1U4S9 Pseudouridine synthase, RluA family n=1 Tax=Desu...   256   5e-67
UniRef50_UPI0001C42CC7 hypothetical protein BpOF4_01845 n=1 Tax=...   256   5e-67
UniRef50_A6NQQ9 Pseudouridine synthase n=1 Tax=Bacteroides capil...   256   6e-67
UniRef50_A6GP31 Pseudouridine synthase n=1 Tax=Limnobacter sp. M...   256   7e-67
UniRef50_C8P3R0 Pseudouridine synthase n=1 Tax=Erysipelothrix rh...   255   9e-67
UniRef50_Q2NIN6 Pseudouridine synthase n=4 Tax=Candidatus Phytop...   255   1e-66
UniRef50_A5ZUU7 Pseudouridine synthase n=1 Tax=Ruminococcus obeu...   255   1e-66
UniRef50_C4XFS9 Pseudouridine synthase n=2 Tax=Mycoplasma RepID=...   255   1e-66
UniRef50_B8CWB7 Pseudouridine synthase n=1 Tax=Halothermothrix o...   255   1e-66
UniRef50_C0QV86 Pseudouridine synthase n=2 Tax=Brachyspira RepID...   255   1e-66
UniRef50_Q3JQ55 Pseudouridine synthase n=170 Tax=cellular organi...   254   1e-66
UniRef50_A5IBH6 Pseudouridine synthase n=6 Tax=Legionella RepID=...   254   2e-66
UniRef50_C6CWL6 Pseudouridine synthase n=2 Tax=Paenibacillus Rep...   254   2e-66
UniRef50_D2R7T3 Pseudouridine synthase, RluA family n=1 Tax=Pire...   254   2e-66
UniRef50_A7H6D3 Pseudouridine synthase n=6 Tax=Cystobacterineae ...   254   2e-66
UniRef50_Q7UHX8 Pseudouridine synthase n=1 Tax=Rhodopirellula ba...   254   2e-66
UniRef50_C0GNZ6 Pseudouridine synthase, RluA family n=1 Tax=Desu...   254   2e-66
UniRef50_B2RIT5 Pseudouridine synthase n=80 Tax=root RepID=B2RIT...   254   3e-66
UniRef50_C5J6Q2 Pseudouridine synthase n=1 Tax=Mycoplasma conjun...   253   4e-66
UniRef50_Q8ZFU1 Ribosomal large subunit pseudouridine synthase C...   253   4e-66
UniRef50_C7H7W3 Ribosomal large subunit pseudouridine synthase D...   253   4e-66
UniRef50_C1A885 Pseudouridine synthase n=1 Tax=Gemmatimonas aura...   253   5e-66
UniRef50_C1CWT3 Pseudouridine synthase n=1 Tax=Deinococcus deser...   252   5e-66
UniRef50_B7GLK3 Pseudouridine synthase n=11 Tax=Bacillaceae RepI...   252   6e-66
UniRef50_A5IZB6 Pseudouridine synthase n=4 Tax=Mycoplasma RepID=...   252   6e-66
UniRef50_P44433 Ribosomal large subunit pseudouridine synthase C...   252   9e-66
UniRef50_A9IIW7 Pseudouridine synthase n=5 Tax=Bordetella RepID=...   252   1e-65
UniRef50_UPI00016C3FBA ribosomal large subunit pseudouridine syn...   251   1e-65
UniRef50_C9M5C8 Pseudouridine synthase n=1 Tax=Jonquetella anthr...   251   2e-65
UniRef50_B7HGW1 Pseudouridine synthase n=52 Tax=Bacillales RepID...   251   2e-65
UniRef50_B8FTI5 Pseudouridine synthase n=2 Tax=Desulfitobacteriu...   251   2e-65
UniRef50_C0ZCK6 Pseudouridine synthase n=1 Tax=Brevibacillus bre...   251   2e-65
UniRef50_A9B3Z2 Pseudouridine synthase n=1 Tax=Herpetosiphon aur...   251   2e-65
UniRef50_D1CBT6 Pseudouridine synthase n=1 Tax=Thermobaculum ter...   251   2e-65
UniRef50_Q2S3B7 Pseudouridine synthase n=1 Tax=Salinibacter rube...   251   2e-65
UniRef50_A0LPH5 Pseudouridine synthase n=1 Tax=Syntrophobacter f...   250   3e-65
UniRef50_D0L1K7 Pseudouridine synthase n=1 Tax=Halothiobacillus ...   250   4e-65
UniRef50_C0Z877 Pseudouridine synthase n=1 Tax=Brevibacillus bre...   250   4e-65
UniRef50_A8RHQ2 Pseudouridine synthase n=2 Tax=Clostridium RepID...   250   4e-65
UniRef50_O67638 Uncharacterized RNA pseudouridine synthase aq_17...   250   4e-65
UniRef50_Q0F3G4 Pseudouridine synthase n=1 Tax=Mariprofundus fer...   249   5e-65
UniRef50_C6LL16 Pseudouridine synthase n=3 Tax=Clostridiales Rep...   249   5e-65
UniRef50_A1HR26 Pseudouridine synthase, RluA family n=1 Tax=Ther...   249   5e-65
UniRef50_A6LDZ7 Pseudouridine synthase n=26 Tax=Bacteroidales Re...   249   6e-65
UniRef50_B6J6C4 Pseudouridine synthase n=7 Tax=Coxiella burnetii...   248   1e-64
UniRef50_D1AV01 Pseudouridine synthase n=2 Tax=Bacteria RepID=D1...   248   1e-64
UniRef50_Q01Q94 Pseudouridine synthase n=1 Tax=Candidatus Soliba...   248   1e-64
UniRef50_B5YAZ5 Pseudouridine synthase n=2 Tax=Dictyoglomus RepI...   247   2e-64
UniRef50_O31613 Uncharacterized RNA pseudouridine synthase yjbO ...   247   3e-64
UniRef50_C9M7B4 Pseudouridine synthase n=1 Tax=Jonquetella anthr...   246   4e-64
UniRef50_C0N6T7 Pseudouridine synthase n=1 Tax=Methylophaga thio...   246   5e-64
UniRef50_B1ZYX0 Pseudouridine synthase n=4 Tax=Verrucomicrobia R...   246   5e-64
UniRef50_C5S931 Pseudouridine synthase n=2 Tax=Gammaproteobacter...   246   6e-64
UniRef50_Q14NK8 Probable pseudouridine synthase d protein n=1 Ta...   246   6e-64
UniRef50_A8MF48 Pseudouridine synthase n=12 Tax=Clostridiaceae R...   246   7e-64
UniRef50_Q0VQN9 Pseudouridine synthase n=2 Tax=Alcanivorax RepID...   245   9e-64
UniRef50_A3Y8C6 Pseudouridine synthase n=1 Tax=Marinomonas sp. M...   245   1e-63
UniRef50_A4J479 Pseudouridine synthase n=1 Tax=Desulfotomaculum ...   245   1e-63
UniRef50_A6DMG7 tRNA pseudouridine synthase n=1 Tax=Lentisphaera...   244   2e-63
UniRef50_B7GEZ0 Pseudouridine synthase n=7 Tax=Bacillaceae RepID...   244   2e-63
UniRef50_A2U235 Pseudouridine synthase n=3 Tax=Flavobacteriaceae...   244   2e-63
UniRef50_C7MN62 Pseudouridine synthase n=8 Tax=Coriobacteriaceae...   244   2e-63
UniRef50_C0MA80 Pseudouridine synthase n=6 Tax=Streptococcus Rep...   243   3e-63
UniRef50_A8F4Z7 Pseudouridine synthase n=2 Tax=Thermotogaceae Re...   243   4e-63
UniRef50_D2RBY1 Pseudouridine synthase, RluA family n=1 Tax=Gard...   242   6e-63
UniRef50_A5INM9 Pseudouridine synthase n=7 Tax=Thermotogaceae Re...   242   8e-63
UniRef50_Q28US1 Pseudouridine synthase n=43 Tax=Rhodobacterales ...   242   9e-63
UniRef50_B8DF66 Pseudouridine synthase n=18 Tax=Listeria RepID=B...   242   1e-62
UniRef50_C7GZW0 Pseudouridine synthase n=1 Tax=Eubacterium saphe...   241   1e-62
UniRef50_B1YJB1 Pseudouridine synthase n=1 Tax=Exiguobacterium s...   241   1e-62
UniRef50_B4U613 Pseudouridine synthase, RluA family n=1 Tax=Hydr...   241   2e-62
UniRef50_P59838 Ribosomal large subunit pseudouridine synthase D...   241   2e-62
UniRef50_Q0F3G2 Possible pseudouridine synthase n=1 Tax=Mariprof...   241   2e-62
UniRef50_B7BE87 Pseudouridine synthase n=8 Tax=Bacteroidales Rep...   241   2e-62
UniRef50_Q83G23 Pseudouridine synthase n=2 Tax=Tropheryma whippl...   241   2e-62
UniRef50_D0MK65 Pseudouridine synthase n=1 Tax=Rhodothermus mari...   241   2e-62
UniRef50_A1WTN6 Pseudouridine synthase n=2 Tax=Ectothiorhodospir...   241   3e-62
UniRef50_D2M2K8 Pseudouridine synthase, RluA family n=1 Tax=Baci...   240   3e-62
UniRef50_C2W5F3 Pseudouridine synthase n=4 Tax=Bacillus RepID=C2...   240   3e-62
UniRef50_C1ZB48 Pseudouridine synthase, RluA family n=1 Tax=Plan...   240   3e-62
UniRef50_B1XXM0 Pseudouridine synthase n=6 Tax=Burkholderiales R...   240   3e-62
UniRef50_Q8ERS8 Pseudouridine synthase n=2 Tax=Bacillaceae RepID...   240   4e-62
UniRef50_Q2RQY9 Pseudouridine synthase n=3 Tax=Alphaproteobacter...   240   5e-62
UniRef50_Q21K97 Pseudouridine synthase n=10 Tax=Gammaproteobacte...   239   5e-62
UniRef50_C5WJF2 Pseudouridine synthase n=104 Tax=Lactobacillales...   239   5e-62
UniRef50_A4J1I1 Pseudouridine synthase n=1 Tax=Desulfotomaculum ...   239   6e-62
UniRef50_A5VJ18 Pseudouridine synthase, RluA family n=13 Tax=Lac...   239   6e-62
UniRef50_B0S119 Pseudouridine synthase n=2 Tax=Finegoldia magna ...   239   6e-62
UniRef50_A5ZQM9 Putative uncharacterized protein n=1 Tax=Ruminoc...   239   6e-62
UniRef50_C0EHV8 Putative uncharacterized protein n=1 Tax=Clostri...   239   6e-62
UniRef50_D1W0M0 Pseudouridine synthase n=1 Tax=Prevotella timone...   239   7e-62
UniRef50_B0TDX6 Pseudouridine synthase, rlua family n=1 Tax=Heli...   239   9e-62
UniRef50_Q0BUM2 Pseudouridine synthase n=12 Tax=Acetobacteraceae...   239   1e-61
UniRef50_Q492Q1 Pseudouridine synthase n=2 Tax=Candidatus Blochm...   239   1e-61
UniRef50_P0AA37 Ribosomal large subunit pseudouridine synthase A...   238   1e-61
UniRef50_B5ZBC1 RluA n=15 Tax=Ureaplasma RepID=B5ZBC1_UREU1           238   1e-61

Sequences not found previously or not previously below threshold:

UniRef50_A1URK8 Pseudouridine synthase n=2 Tax=Bartonella RepID=...   274   2e-72
UniRef50_A6SXT6 Pseudouridine synthase n=1 Tax=Janthinobacterium...   273   3e-72
UniRef50_D0MJ49 Pseudouridine synthase n=2 Tax=Bacteria RepID=D0...   273   5e-72
UniRef50_Q312A0 Pseudouridine synthase, RluD n=6 Tax=Bacteria Re...   271   1e-71
UniRef50_D1RB31 Pseudouridine synthase n=1 Tax=Parachlamydia aca...   269   5e-71
UniRef50_C0QAZ3 RluD1 n=1 Tax=Desulfobacterium autotrophicum HRM...   258   2e-67
UniRef50_B6BTN1 Pseudouridine synthase n=2 Tax=Betaproteobacteri...   257   3e-67
UniRef50_C8WW59 Pseudouridine synthase n=2 Tax=Alicyclobacillus ...   256   6e-67
UniRef50_A3RGY8 Pseudouridine synthase n=1 Tax=uncultured bacter...   255   9e-67
UniRef50_A4WSV2 Pseudouridine synthase n=41 Tax=Alphaproteobacte...   254   2e-66
UniRef50_Q6MEC0 Pseudouridine synthase n=1 Tax=Candidatus Protoc...   253   3e-66
UniRef50_C1FEQ4 Predicted protein n=2 Tax=Micromonas RepID=C1FEQ...   251   1e-65
UniRef50_C1SM47 Pseudouridine synthase n=1 Tax=Denitrovibrio ace...   250   3e-65
UniRef50_C8S0A2 Pseudouridine synthase n=1 Tax=Rhodobacter sp. S...   250   3e-65
UniRef50_A4RT55 Predicted protein (Fragment) n=3 Tax=Chlorophyta...   249   8e-65
UniRef50_Q5PAD0 Pseudouridine synthase n=5 Tax=Anaplasma RepID=Q...   248   1e-64
UniRef50_C0QPR5 Pseudouridine synthase n=4 Tax=Hydrogenothermace...   248   1e-64
UniRef50_C2D7A7 Pseudouridine synthase n=1 Tax=Atopobium vaginae...   247   4e-64
UniRef50_B3DV48 Pseudouridine synthase n=1 Tax=Methylacidiphilum...   246   6e-64
UniRef50_A3DDK9 Pseudouridine synthase, RluA family n=3 Tax=Clos...   245   9e-64
UniRef50_Q2GGY1 Pseudouridine synthase n=13 Tax=Rickettsiales Re...   244   2e-63
UniRef50_Q1Q689 Similar to ribosomal large subunit pseudouridine...   242   8e-63
UniRef50_Q89AD9 Ribosomal large subunit pseudouridine synthase D...   240   3e-62
UniRef50_Q6MGX8 Pseudouridine synthase n=1 Tax=Bdellovibrio bact...   240   4e-62

>UniRef50_Q47417 tRNA pseudouridine synthase C n=252 Tax=cellular organisms
           RepID=TRUC_PECCC
          Length = 376

 Score =  360 bits (925), Expect = 3e-98,   Method: Composition-based stats.
 Identities = 182/257 (70%), Positives = 209/257 (81%)

Query: 1   MLEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGV 60
           MLEI+YQDE LVAVNKPSGWLVHRSWLDR EKVVVMQTVRDQIGQHV+T HRLDRPTSGV
Sbjct: 115 MLEIIYQDEHLVAVNKPSGWLVHRSWLDRKEKVVVMQTVRDQIGQHVYTVHRLDRPTSGV 174

Query: 61  LLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDK 120
           LL+ LSSE  R L+QQFE HQ+QK YHA+VRG+++++ V+DY L EELDKIADKF   DK
Sbjct: 175 LLLALSSEVARALSQQFESHQMQKTYHAVVRGYVLDDGVIDYALTEELDKIADKFTNPDK 234

Query: 121 GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSK 180
            PQPAVTHYR LA  EMPVA GRYPT RY L+EL+P+TGRKHQLRRH++H+ HPIIGD+ 
Sbjct: 235 APQPAVTHYRSLAQAEMPVAIGRYPTARYSLMELKPQTGRKHQLRRHMSHIHHPIIGDTA 294

Query: 181 HGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWRGLL 240
           HGDLR NR    HF   RLMLHAS+L L HP +G+PLT+ A  D  W   ++QFGW+G+L
Sbjct: 295 HGDLRHNRGMESHFSCGRLMLHASELQLNHPVSGQPLTLQARWDAPWQGVVTQFGWKGIL 354

Query: 241 PENERVEFSAPSGQDGE 257
           PE E VEF A SGQD E
Sbjct: 355 PEFEGVEFPADSGQDSE 371


>UniRef50_Q8DBG5 tRNA pseudouridine synthase C n=54 Tax=Gammaproteobacteria
           RepID=TRUC_VIBVU
          Length = 245

 Score =  316 bits (810), Expect = 6e-85,   Method: Composition-based stats.
 Identities = 143/240 (59%), Positives = 175/240 (72%)

Query: 1   MLEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGV 60
           MLEI+YQDE+ VAVNKP+G LVHRSWLD+ E   VMQT+RDQIGQHVF  HRLDRPTSGV
Sbjct: 1   MLEIVYQDEYFVAVNKPAGMLVHRSWLDKHETQFVMQTLRDQIGQHVFPLHRLDRPTSGV 60

Query: 61  LLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDK 120
           L+  LSSE    +   F   ++ K YHAIVRGW+ EE  LDY L  ELDKIADKFA ++K
Sbjct: 61  LVFALSSEVASQVMPMFAGQEMSKTYHAIVRGWIEEEGELDYALKVELDKIADKFASQEK 120

Query: 121 GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSK 180
             Q A+T Y+ LA VE+P +T ++PTTRYGL+EL+PKTGRKHQLRRH+AHLRHPI+GD+ 
Sbjct: 121 EAQDAITLYKPLAKVEVPYSTSKFPTTRYGLMELKPKTGRKHQLRRHMAHLRHPIVGDTT 180

Query: 181 HGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWRGLL 240
           HGD + N+   E F   RL+LHAS+L   HP+T + + I A +D  W Q   +F W   L
Sbjct: 181 HGDGKHNKLFREEFDAPRLLLHASELRFVHPYTQQEVVIRAEVDKVWQQLFERFEWPSTL 240


>UniRef50_B8CQ92 Pseudouridine synthase n=1 Tax=Shewanella piezotolerans WP3
           RepID=B8CQ92_SHEPW
          Length = 278

 Score =  310 bits (795), Expect = 3e-83,   Method: Composition-based stats.
 Identities = 126/235 (53%), Positives = 160/235 (68%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           +EIL++D+ +VA++KP+G LVHRS+L R E+   MQ  RD++G HVF  HRLDRPTSG+L
Sbjct: 27  IEILFEDDDVVAIHKPAGLLVHRSYLARRERFFAMQLTRDKVGCHVFPVHRLDRPTSGIL 86

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKG 121
           L   SSE    L +QF  H I K Y AIVRG + E A LDY L EELD +ADK    +K 
Sbjct: 87  LFAKSSEMANALCEQFAAHSIDKEYLAIVRGNMHEAATLDYALKEELDDVADKDVDPNKA 146

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
            Q A+T Y+ L   E+P A+GRY T+RY LV L P TGRKHQLRRH+AHLRHPI+GD+ H
Sbjct: 147 AQDAITSYKPLLNSEIPYASGRYATSRYALVHLSPHTGRKHQLRRHMAHLRHPILGDTTH 206

Query: 182 GDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGW 236
           GD +QN+   EHFG+ RL L A +LS  HP TGE + +   L+  W+    + GW
Sbjct: 207 GDGKQNKFFREHFGINRLWLIAKKLSFNHPRTGERVAVETELEQEWITLFDELGW 261


>UniRef50_Q30SZ1 Pseudouridine synthase n=2 Tax=Proteobacteria RepID=Q30SZ1_SULDN
          Length = 241

 Score =  304 bits (780), Expect = 2e-81,   Method: Composition-based stats.
 Identities = 122/236 (51%), Positives = 166/236 (70%)

Query: 1   MLEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGV 60
           MLEILYQDE LVA+NKPSG LVHRS +DR E    +QT+R+Q+G+ V+  HRLD+PTSGV
Sbjct: 1   MLEILYQDEHLVAINKPSGLLVHRSPIDRHETEFAIQTLRNQLGRFVYPIHRLDKPTSGV 60

Query: 61  LLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDK 120
           LL  L  E+ +++ ++F  H+ +K Y A+VRG+ ++   +DY L  + DKIADK +  DK
Sbjct: 61  LLFALDKESAKIMGEKFMAHEAKKSYIAVVRGYTLQSGEIDYALSIKFDKIADKDSSSDK 120

Query: 121 GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSK 180
            PQ A+THY+ LATVE+    G+Y  TRY LV+L P TGRKHQLRRH+ H+ H I+GD+K
Sbjct: 121 EPQEALTHYKRLATVELDFEVGKYDKTRYSLVKLNPLTGRKHQLRRHMKHISHHILGDTK 180

Query: 181 HGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGW 236
           +G    N+   + FG  R++LHA  L ++HP+T E L I A LD T+++  S FGW
Sbjct: 181 YGRGEHNKLIRQEFGCHRMLLHAIALEISHPYTKELLYIKAPLDVTFIEMFSFFGW 236


>UniRef50_Q15QZ8 Pseudouridine synthase n=5 Tax=Bacteria RepID=Q15QZ8_PSEA6
          Length = 252

 Score =  299 bits (766), Expect = 8e-80,   Method: Composition-based stats.
 Identities = 129/251 (51%), Positives = 163/251 (64%), Gaps = 2/251 (0%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           L ILYQDE LVA++KP+G LVHRS +DR E    MQ +RDQIGQHVF  HRLDRPTSGVL
Sbjct: 3   LTILYQDECLVAIHKPAGLLVHRSMIDRHETQFAMQMLRDQIGQHVFPVHRLDRPTSGVL 62

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKG 121
           +  LS++  RLL +QF  + I K Y AIVRG + E  ++DY L E+LDKIADK A++DK 
Sbjct: 63  VFALSADIARLLGEQFAGNTIAKTYFAIVRGHVKEAGLIDYALKEKLDKIADKRAKQDKD 122

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
            Q A T Y  L   E+P A  RYP+ RY LV L PKTGRKHQLRRH+ H+ HPI+GD+ H
Sbjct: 123 AQEAQTEYVPLQQFELPFAVSRYPSARYTLVRLHPKTGRKHQLRRHMCHINHPIVGDTTH 182

Query: 182 GDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWRGLLP 241
           GD + N+   + F    L L   Q+ +THP + E L I    D      + Q+GW   LP
Sbjct: 183 GDGKHNKFMRDQFSFNGLALTCQQMCMTHPVSNEKLAIVNDFDQRMSTLMVQWGWE--LP 240

Query: 242 ENERVEFSAPS 252
             +R++  + S
Sbjct: 241 SLDRLDLLSNS 251


>UniRef50_Q39Z12 Pseudouridine synthase n=3 Tax=Proteobacteria RepID=Q39Z12_GEOMG
          Length = 270

 Score =  298 bits (764), Expect = 1e-79,   Method: Composition-based stats.
 Identities = 123/242 (50%), Positives = 160/242 (66%), Gaps = 1/242 (0%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           +EILY+DE LVAV+KP G LVHRS +DR E    +Q VRD +G+ V+  HRLD+PTSGVL
Sbjct: 1   MEILYRDEHLVAVHKPLGLLVHRSPIDRHETRFALQEVRDLLGRRVYPVHRLDKPTSGVL 60

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE-DK 120
           L  L     R L   F    + K Y A+VRG + EE V+D+PL EE D+         ++
Sbjct: 61  LFALDPAFARGLVGAFASGSVTKTYLAVVRGTMPEEGVIDHPLAEEPDRFEQGRGNAGER 120

Query: 121 GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSK 180
            PQ AVT YR LA VE+PVA GRYPT+RY LV L P+TGR+HQLRRHL HL HPI+GD+K
Sbjct: 121 APQSAVTGYRRLADVELPVAVGRYPTSRYSLVSLSPRTGRRHQLRRHLKHLFHPIVGDTK 180

Query: 181 HGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWRGLL 240
           +G+ R NR   E     R++LHA +L++ HP TG PLT+ A ++  +   L++FGW   +
Sbjct: 181 YGEGRHNRFFREELLTVRMLLHAVELTVPHPATGAPLTVCAPVEGAFAALLARFGWLSAV 240

Query: 241 PE 242
           P 
Sbjct: 241 PS 242


>UniRef50_C5TPY8 Pseudouridine synthase n=6 Tax=Proteobacteria RepID=C5TPY8_NEIFL
          Length = 264

 Score =  297 bits (762), Expect = 2e-79,   Method: Composition-based stats.
 Identities = 127/235 (54%), Positives = 161/235 (68%), Gaps = 3/235 (1%)

Query: 1   MLEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGV 60
           ML+I+++D   +AVNKP+G LVHRSWLD+ E    +QT+RDQIGQHV+  HRLDRPTSGV
Sbjct: 27  MLDIIHRDSRTIAVNKPAGMLVHRSWLDKHETRFAVQTLRDQIGQHVYPVHRLDRPTSGV 86

Query: 61  LLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDK 120
           LL  L +EA RLL QQFE   I+K Y AIVRG+L  + ++DY L    DKIA+  A+ + 
Sbjct: 87  LLFALDTEAARLLTQQFENKTIEKTYWAIVRGYLPSDGLIDYALKYMPDKIAE--AQTEA 144

Query: 121 GPQPAVTHYRGLATVEMPVATG-RYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDS 179
             Q A T YR LA  E+P  +  RYPT+RY   EL P TGRKHQLRRH+ H+ HPI+GD+
Sbjct: 145 TLQEAQTAYRCLAQTELPFQSALRYPTSRYSWAELTPYTGRKHQLRRHMKHIFHPIVGDT 204

Query: 180 KHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
            +GDLRQN + AEH G QRLMLHA  LS      G  +T++A  D+ W   + +F
Sbjct: 205 NYGDLRQNHAVAEHIGTQRLMLHARSLSFQSIEDGSRITVNAPTDNDWRLWMEKF 259


>UniRef50_B0TGQ0 Pseudouridine synthase n=44 Tax=Bacteria RepID=B0TGQ0_HELMI
          Length = 369

 Score =  297 bits (762), Expect = 2e-79,   Method: Composition-based stats.
 Identities = 76/251 (30%), Positives = 125/251 (49%), Gaps = 27/251 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIGQ----HVFTAHRLDR 55
           LEI++QD  +  +NKP+G +VH +       +V  ++  ++D  G          HR+D+
Sbjct: 112 LEIIFQDADIAVINKPAGLVVHPAEGHWSGTLVNALLYHIKDLSGINGELRPGIVHRIDK 171

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADK 114
            TSG+L++  +  A   L +Q + H++++ Y A+V G +  E   ++ P+  +       
Sbjct: 172 DTSGLLVVAKNDRAHIHLTEQVKDHRVRREYLAVVHGVIGAETGRVEAPIGRDPKDRQRM 231

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
                 G + A+TH+R LA         RYP   + L+    +TGR HQ+R HLAH+ HP
Sbjct: 232 AVI--AGGKSAITHFRVLA---------RYPEQGFSLLHCRLETGRTHQIRVHLAHIGHP 280

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           + GD K+G  +        FGL    LHA +L   HP +GEP+   A   + ++Q L   
Sbjct: 281 VAGDPKYGPRKA------AFGLTGQALHAWKLEFVHPRSGEPMRFQADPPEPFVQVLQAL 334

Query: 235 GWRGLLPENER 245
               + P N+R
Sbjct: 335 Q---MTPTNQR 342


>UniRef50_B9Y836 Pseudouridine synthase n=3 Tax=Firmicutes RepID=B9Y836_9FIRM
          Length = 307

 Score =  296 bits (760), Expect = 4e-79,   Method: Composition-based stats.
 Identities = 73/243 (30%), Positives = 120/243 (49%), Gaps = 26/243 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIGQ----HVFTAHRLDR 55
           L ++Y+D  ++ +NKP G +VH    + D  +V  ++    D  G          HR+D+
Sbjct: 80  LNVVYEDHDVIVINKPKGLVVHPGPGNPDHTLVNGLLWHCHDLSGINGVLRPGIVHRIDK 139

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADK 114
            TSG+++   +  A + LA+Q  +    ++Y+A+V G +  E   +D P+  + +K   K
Sbjct: 140 DTSGLIVACKNDNAHQSLAKQLAEKTAGRQYYALVHGVINHEYGTIDAPIGRD-EKDRQK 198

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
            A  +K  +PA+TH++ +   +            Y LV    +TGR HQ+R H+ ++  P
Sbjct: 199 MAVTEKNSRPAITHFKVVERFD-----------NYTLVSCRLETGRTHQIRVHMQYIGFP 247

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           I+GD K+       S  +    Q  MLHA QLS THP TGE +T  A L   +   L+Q 
Sbjct: 248 IVGDPKY-------SLRKTLPTQGQMLHAYQLSFTHPSTGERMTFEAPLPPEFEALLTQL 300

Query: 235 GWR 237
              
Sbjct: 301 RQE 303


>UniRef50_Q3ABZ7 Pseudouridine synthase n=2 Tax=Bacteria RepID=Q3ABZ7_CARHZ
          Length = 305

 Score =  294 bits (753), Expect = 2e-78,   Method: Composition-based stats.
 Identities = 75/240 (31%), Positives = 121/240 (50%), Gaps = 25/240 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ------HVFTAHRLDR 55
           L+I+Y+DE LV VNK +G +VH +  + D  +V       Q              HRLD+
Sbjct: 82  LDIVYEDEDLVVVNKKAGMVVHPAEGNWDGTLVNALLYHCQNLSGIGGVLRPGIVHRLDK 141

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADK 114
            TSG+L++  +  A + LA+Q ++ +  + Y  IV G+L  +E ++D P+     +   K
Sbjct: 142 DTSGLLVVAKNDLAHQSLAEQIKEKKAVREYWTIVHGYLKNKEGIIDLPIGRHP-RDRQK 200

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
            A    G + A T Y+ L                + L++ +  TGR HQ+R H ++L HP
Sbjct: 201 MAVVSNG-KTAQTVYKVLEEF----------NKGFTLIQAKLLTGRTHQIRVHFSYLGHP 249

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           ++GD K+G           FG++R MLHA +LS  HP +GE L   A L + + + L++ 
Sbjct: 250 VLGDPKYGHQ------NNPFGVKRQMLHAIKLSFIHPRSGELLEFTAPLPEDFQRVLAKL 303


>UniRef50_C6XFD0 Pseudouridine synthase n=1 Tax=Candidatus Liberibacter asiaticus
           str. psy62 RepID=C6XFD0_LIBAP
          Length = 340

 Score =  293 bits (752), Expect = 3e-78,   Method: Composition-based stats.
 Identities = 61/257 (23%), Positives = 123/257 (47%), Gaps = 27/257 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIG-----QHVFTAHRLD 54
           L+ILY+D+ ++ +NKP+G +VH +  +    +V  ++    + +      +     HRLD
Sbjct: 90  LDILYEDDDIIVINKPAGLVVHPAPGNWTGTLVNALLYHCHNNLSSINGVKRPGIVHRLD 149

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQH----QIQKRYHAIVRGWL-MEEAVLDYPLVEELD 109
           + T+GV+++  +  A + L++QF  H    ++++ Y+A+V G    +  +++ PL     
Sbjct: 150 KDTTGVMVVAKNDLAHQKLSEQFVDHGKSTRLKRAYYAMVWGIPLPDSGIINAPLGRCKS 209

Query: 110 KIADKFAR--EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRH 167
               +  +  +DK    A+THY+ +          +       L++   +TGR HQ+R H
Sbjct: 210 NRLRRAVKGIDDKTADSAITHYQTIE------IYNKNSNFAVSLLKCHLETGRTHQIRVH 263

Query: 168 LAHLRHPIIGDSKHGDLRQ-------NRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIH 220
           +AH  +P+IGD  +G   +       N + +    L R  LHA  LS +HP   + +   
Sbjct: 264 MAHKGNPLIGDPLYGKGFKTKANIVNNNAKSAILSLARQALHAHSLSFSHPRNNQDMDFQ 323

Query: 221 AGLDDTWMQALSQFGWR 237
             + +  +  + +   +
Sbjct: 324 VPIPEDMLTVIRKLNEK 340


>UniRef50_C4KBT4 Transaldolase n=2 Tax=Proteobacteria RepID=C4KBT4_THASP
          Length = 648

 Score =  293 bits (750), Expect = 6e-78,   Method: Composition-based stats.
 Identities = 124/272 (45%), Positives = 164/272 (60%), Gaps = 24/272 (8%)

Query: 1   MLEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGV 60
           MLEILY+D+WLVA++KPSG LVHRS +   E+   +Q +RDQ+G+ V+ AHRLDR TSGV
Sbjct: 1   MLEILYRDDWLVAIHKPSGLLVHRSPIAAHEERFAVQLLRDQLGRRVYPAHRLDRGTSGV 60

Query: 61  LLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAR--- 117
           LL  L  E  R LAQ+FE   + KRY A+VRG   E  V+++ LV  LD +  +  +   
Sbjct: 61  LLFALDREVARTLAQRFEAQAVDKRYLAVVRGHPPEHGVIEHALVRRLDAVEVRSGKGAG 120

Query: 118 -----------------EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGR 160
                             +   QPA T +R LATVE+P A  RYP++RY LVEL P+TGR
Sbjct: 121 ARDALPEDVDDSDSPEAAEPVAQPARTRFRRLATVELPHAVDRYPSSRYALVELLPETGR 180

Query: 161 KHQLRRHLAHLRHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIH 220
           +HQLRRHL H+ HPIIGD+ +G  R NR     FG  RL+L  ++L+L HP T  PL I 
Sbjct: 181 RHQLRRHLKHIAHPIIGDATYGKGRHNRLFQALFGSHRLLLACTRLALAHPVTERPLEIV 240

Query: 221 AGLDDTWMQALSQFGWRGLLPENERVEFSAPS 252
           A + + +   L+  GW+      +R  F A S
Sbjct: 241 APVAEDFAAVLAALGWQ----TAQRSTFEAES 268


>UniRef50_C0Q9S8 TruC n=1 Tax=Desulfobacterium autotrophicum HRM2 RepID=C0Q9S8_DESAH
          Length = 260

 Score =  291 bits (747), Expect = 1e-77,   Method: Composition-based stats.
 Identities = 113/244 (46%), Positives = 140/244 (57%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           LEILYQDE LVAVNKP G LVHR+ L   E    +Q VRDQ   HVF  HRLDRPT GVL
Sbjct: 13  LEILYQDEDLVAVNKPPGLLVHRTALATHETRFALQMVRDQTQGHVFPVHRLDRPTQGVL 72

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKG 121
           L   +      ++  F+  +IQK Y A+VRG + E   + +PL        +K       
Sbjct: 73  LFARNRNMATRMSHLFQTGKIQKTYLAVVRGHVKERGTIVHPLKNIKHPQDNKRINHSLK 132

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
              AVT Y  LA+VE+P    RYPTTRY LV L PKTGR+HQLRRH+ H+ HPI+GD+ +
Sbjct: 133 IDDAVTDYACLASVELPFYVDRYPTTRYCLVALIPKTGRRHQLRRHMKHISHPIVGDTVY 192

Query: 182 GDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWRGLLP 241
           G    NR  A H     L+L A +L   HP TG  +TI A LD  + + +S+F W     
Sbjct: 193 GKSSHNRFFATHLNCTGLLLAARELCFVHPDTGIFITITAPLDKRFQEVISKFSWDEPTK 252

Query: 242 ENER 245
           E  R
Sbjct: 253 ELPR 256


>UniRef50_A3HSB5 Pseudouridine synthase n=1 Tax=Algoriphagus sp. PR1
           RepID=A3HSB5_9SPHI
          Length = 237

 Score =  290 bits (743), Expect = 4e-77,   Method: Composition-based stats.
 Identities = 105/243 (43%), Positives = 143/243 (58%), Gaps = 12/243 (4%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           L IL++D+ ++A+NKP+G LVHR+ +   E V  +Q +RDQIG HV   HRLDRPTSG+L
Sbjct: 3   LPILFEDDSIIAINKPAGLLVHRTSIAAQETVFALQILRDQIGMHVHPVHRLDRPTSGIL 62

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADKFAREDK 120
           L     E    L   F + QI+K Y  IVRG    ++A++D+PL  E             
Sbjct: 63  LFAKKEEILPHLKNLFSERQIKKNYLTIVRGIPEQKKALIDHPLKSERSGRL-------- 114

Query: 121 GPQPAVTHYRGLATVEMPV-ATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDS 179
             Q A T Y+ ++  E+P   TGRYPT+RY L+ + P+TGR HQ+RRHLAH+RH IIGD 
Sbjct: 115 --QEAQTWYKVISETEIPFDTTGRYPTSRYSLLSVNPETGRTHQIRRHLAHIRHYIIGDK 172

Query: 180 KHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWRGL 239
           KHGD +QN      FGL+ L+LHA +LS  HP T E + I   + + +   L     +  
Sbjct: 173 KHGDNKQNIFFQNQFGLENLLLHAIRLSFNHPITEETIEISCPVPEHFQSILKSLNLQEP 232

Query: 240 LPE 242
           L  
Sbjct: 233 LIS 235


>UniRef50_C7NAV5 Pseudouridine synthase n=5 Tax=Fusobacteriaceae RepID=C7NAV5_LEPBD
          Length = 326

 Score =  288 bits (738), Expect = 1e-76,   Method: Composition-based stats.
 Identities = 69/244 (28%), Positives = 118/244 (48%), Gaps = 28/244 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVV--MQTVRDQIGQ----HVFTAHRLDR 55
           +EI+Y+D  L  +NK +G +VH +       +V   +  ++D  G          HRLD+
Sbjct: 99  IEIIYEDNDLAVINKKAGIVVHPANGHYSGTLVNAILYHIKDLSGINGEIRPGIVHRLDK 158

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADK 114
            TSG+L++  + +A   L+Q F    ++K Y AI++G L ++   +   +  + +     
Sbjct: 159 DTSGLLIIAKNDKAHLKLSQMFHDKTVKKIYLAILKGKLNQKSGRIVTQIGRDKNDRKKM 218

Query: 115 FARED-KGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
               D    + A+T+Y  ++  E           ++ LV++  +TGR HQ+R H+ HL +
Sbjct: 219 TVINDLNSGKTAITNYEVISQTE-----------KFTLVKVHIETGRTHQIRVHMKHLGY 267

Query: 174 PIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           PI+GDS +G              +R MLHA +L   HP T E L   A L + + +AL +
Sbjct: 268 PILGDSVYGRTDTE---------KRQMLHAYKLEFQHPITEENLEFIAKLPEDFKKALKK 318

Query: 234 FGWR 237
            G  
Sbjct: 319 CGLE 322


>UniRef50_Q6AJM1 Pseudouridine synthase n=1 Tax=Desulfotalea psychrophila
           RepID=Q6AJM1_DESPS
          Length = 327

 Score =  288 bits (738), Expect = 1e-76,   Method: Composition-based stats.
 Identities = 71/243 (29%), Positives = 117/243 (48%), Gaps = 21/243 (8%)

Query: 5   LYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIGQ----HVFTAHRLDRPTS 58
           +Y+D+ L+ ++KP G +VH    + +  +V  ++   R+  G          HRLD+ TS
Sbjct: 98  IYEDDSLLVLSKPPGIVVHPGNGNTEGTLVHGLLYHCREIGGVGDAIRPGIVHRLDKDTS 157

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADKFAR 117
           G +++     + R L   F++ Q+ K YHA+V G   + E  +  P+         K A 
Sbjct: 158 GAMVVAKDERSLRTLVDSFKERQVYKVYHALVCGIPKKYEGRIVAPIGRHSVH-RQKMAI 216

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
            ++  + A T+++ +   E            Y L+ +  +TGR HQ+R H++ +  PI G
Sbjct: 217 SERTGKFAATNWQVVEVFET-------KDGPYSLLRVHIETGRTHQIRVHMSSIGCPIAG 269

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWR 237
           D  +G  RQN + A      R MLHAS+L L HP TG  ++  A L   + + L    W 
Sbjct: 270 DQVYGSKRQNPAFA------RQMLHASRLRLPHPVTGRTMSFTAPLWQDFQEVLEDMDWS 323

Query: 238 GLL 240
           G L
Sbjct: 324 GAL 326


>UniRef50_C8PZW5 Pseudouridine synthase n=1 Tax=Enhydrobacter aerosaccus SK60
           RepID=C8PZW5_9GAMM
          Length = 266

 Score =  286 bits (734), Expect = 4e-76,   Method: Composition-based stats.
 Identities = 134/264 (50%), Positives = 164/264 (62%), Gaps = 27/264 (10%)

Query: 1   MLEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGV 60
           MLEILYQDE  VAVNKP+G LVHRSWLDR E   VMQT+RDQ+ Q+V+  HRLDRPTSGV
Sbjct: 1   MLEILYQDEHCVAVNKPAGMLVHRSWLDRHETEFVMQTLRDQLAQYVYPIHRLDRPTSGV 60

Query: 61  LLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM----EEAVLDYPLVEELDKIADK-- 114
           LL  LSSE+ R L +QFE  Q+QK Y AIVRG+L        ++DYPL + LDKI DK  
Sbjct: 61  LLFALSSESARQLCEQFENRQVQKSYLAIVRGYLTVNAQTSGLIDYPLTQILDKIGDKPS 120

Query: 115 --------FAREDKGP------------QPAVTHYRGLATVEMPV-ATGRYPTTRYGLVE 153
                    +  D               QPA TH++ LAT E P  A  RYPT+R+ L  
Sbjct: 121 LQALQQRKVSSTDMFAEALSSPAELTLLQPAQTHWQCLATTEQPFQARARYPTSRFSLAR 180

Query: 154 LEPKTGRKHQLRRHLAHLRHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFT 213
           L P TGRKHQLRRH+ H+ HPIIGD+ +GD  QNR+  +H G+ RLMLHA  L+      
Sbjct: 181 LTPITGRKHQLRRHMKHVFHPIIGDTSYGDHHQNRAIRQHIGVHRLMLHAHTLAFNRLTD 240

Query: 214 GEPLTIHAGLDDTWMQALSQFGWR 237
              + I A +D  W+   +QFG+ 
Sbjct: 241 NRRVDITAPVDTDWLTMCAQFGFH 264


>UniRef50_C4FYR8 Pseudouridine synthase n=1 Tax=Abiotrophia defectiva ATCC 49176
           RepID=C4FYR8_ABIDE
          Length = 326

 Score =  286 bits (733), Expect = 6e-76,   Method: Composition-based stats.
 Identities = 72/241 (29%), Positives = 117/241 (48%), Gaps = 22/241 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIGQ-----HVFTAHRLD 54
           L+ILY+DE ++ +NKP G +VH +       +V  +M   RD +            HR+D
Sbjct: 99  LDILYEDEDVILINKPKGMVVHPAAGHYTGTLVNALMYHCRDNLSGINGELRPGIVHRID 158

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIAD 113
             T+GV++   +  + R++A+Q ++H I+++Y AIV G    EE  ++  +         
Sbjct: 159 MDTTGVIIACKNDVSHRIIAEQLKEHSIKRKYQAIVYGVFKDEEGRIEGSIGRSKTDRKK 218

Query: 114 KFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
                D   +PAVTHYR +     P          +  +E E +TGR HQ+R H+  + H
Sbjct: 219 MAVIPD--GKPAVTHYRVIRNYTSPN------GNNFAHIECELETGRTHQIRVHMTSIGH 270

Query: 174 PIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           P++GD  +G      +    F L    LHA  L   HP TGE +  HA L + + + L++
Sbjct: 271 PLLGDEIYG------AAKNPFKLDGQALHAEMLGFVHPRTGEYMEFHAPLPEYFSKLLTK 324

Query: 234 F 234
            
Sbjct: 325 L 325


>UniRef50_B2UL66 Pseudouridine synthase n=2 Tax=Verrucomicrobiaceae
           RepID=B2UL66_AKKM8
          Length = 323

 Score =  286 bits (732), Expect = 6e-76,   Method: Composition-based stats.
 Identities = 75/258 (29%), Positives = 115/258 (44%), Gaps = 23/258 (8%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIG----QHVFTAHRLDR 55
           L+ILY+DE +V +NK SG +VH +  + D  +V  ++    D  G    +     HRLD+
Sbjct: 77  LDILYEDEDVVVINKESGMVVHPAAGNPDGTIVNALLHHCGDLSGIGGVERPGIVHRLDK 136

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADK 114
            TSG L++  +  A + L  QF     +KRY A+V+G   +    +   +          
Sbjct: 137 DTSGCLVIAKNDGAHQSLTAQFAARSTEKRYLAVVQGIPSQSSGTVFTHIGRHPVNRLKM 196

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
                   + A+T Y  L            P+T   LV     TGR HQ+R H+ +L HP
Sbjct: 197 AVVNPGSGKAAITDYDLLCAD---------PSTDSSLVLCTLHTGRTHQIRVHMLYLGHP 247

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           +IGD  +    + ++        RLMLHA +L   HP TG+ +   A +   +   L  F
Sbjct: 248 LIGDPIYAKPARQKAKP-----GRLMLHAWRLGFDHPRTGKRMDFEAPVPPEYTPWLQLF 302

Query: 235 --GWRGLLPENERVEFSA 250
             G  G +PE   V+   
Sbjct: 303 PNGLYGAIPELRPVQEDG 320


>UniRef50_Q45826 Uncharacterized RNA pseudouridine synthase Caur_0901 n=5
           Tax=Chloroflexi (class) RepID=Y901_CHLAA
          Length = 316

 Score =  286 bits (732), Expect = 6e-76,   Method: Composition-based stats.
 Identities = 76/242 (31%), Positives = 109/242 (45%), Gaps = 24/242 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ-----HVFTAHRLDRP 56
           L+++Y+D  +  +NKP+G +VH +       +V     R               HRLDR 
Sbjct: 91  LDVVYEDADIAVINKPAGMVVHPAPGHPRGTLVNALLARYPDLAIGGELRPGIVHRLDRD 150

Query: 57  TSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFA 116
           TSG+L++    +A R L  Q +  +++K Y A+V G   E   +D P+  +         
Sbjct: 151 TSGLLVIARHDQAMRSLVDQQQARRMRKIYQALVIGRPPETGTIDAPIGRDPRDRLRMAV 210

Query: 117 REDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPII 176
             D   +PA THYR L T              Y L+E++ +TGR HQ+R HL HL +PI+
Sbjct: 211 VPD--GRPARTHYRLLDTF-----------GDYSLLEVQLETGRTHQIRVHLRHLGYPIV 257

Query: 177 GDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGW 236
           GD  +G  R       H  L R  LHA+ L L HP +G      A L       L Q   
Sbjct: 258 GDPVYGPRRS------HLHLSRQFLHAAYLGLVHPRSGRWQEFTAPLPADLQIVLRQLQD 311

Query: 237 RG 238
           R 
Sbjct: 312 RA 313


>UniRef50_A1K5H7 Pseudouridine synthase n=5 Tax=Proteobacteria RepID=A1K5H7_AZOSB
          Length = 260

 Score =  284 bits (729), Expect = 1e-75,   Method: Composition-based stats.
 Identities = 117/256 (45%), Positives = 154/256 (60%), Gaps = 3/256 (1%)

Query: 1   MLEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGV 60
           MLEILYQDE LVA++KPSG LVHRS LD  E+   +Q +RDQ+G+HV   HRLD+ TSGV
Sbjct: 1   MLEILYQDEHLVAIHKPSGLLVHRSALDAHEERFAVQLLRDQLGRHVHPVHRLDKGTSGV 60

Query: 61  LLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDK 120
           L+  L  +    LA QFE   ++K+Y AIVRG   E   +D+PL    D +      +  
Sbjct: 61  LVFALDRDTAGRLATQFETRAVRKQYVAIVRGHPAEAGTIDHPLSRRFDPVEHVAEDKVF 120

Query: 121 GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSK 180
            PQPA+T +R LAT E+P A  RYPT+RY L+ LEP+TGR+HQ+RRHL H+ HPIIGDS 
Sbjct: 121 APQPAITRFRRLATAELPWAVDRYPTSRYALLALEPETGRRHQIRRHLKHISHPIIGDST 180

Query: 181 HGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWRGLL 240
            G  + NR    HFG +R++L  + + L HP    PL +HA     +       GW   L
Sbjct: 181 FGKGKHNRMFQAHFGSERMLLACTDIELRHPQRDAPLQLHAAPAPDFRAVADALGWHDAL 240

Query: 241 PENERVEFSAPSGQDG 256
               R+     +G + 
Sbjct: 241 ---ARLPADGDTGHNA 253


>UniRef50_UPI0001AEC02F pseudouridylate synthase, 23S RNA-specific n=1 Tax=Alteromonas
           macleodii ATCC 27126 RepID=UPI0001AEC02F
          Length = 279

 Score =  284 bits (728), Expect = 2e-75,   Method: Composition-based stats.
 Identities = 117/233 (50%), Positives = 153/233 (65%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           L +LYQDE ++A+ KP G LVHRS +DR E V  +QT+RDQIGQHV+ AHRLDRPTSGVL
Sbjct: 42  LPVLYQDEHIIAIEKPPGLLVHRSPIDRHETVFAVQTLRDQIGQHVYPAHRLDRPTSGVL 101

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKG 121
           +   SSE    L QQ    Q+ K YHAIVRG++     +DY L    DKIADK  R  + 
Sbjct: 102 VFSFSSEIAAKLGQQMMDKQVVKTYHAIVRGFVHHTGYIDYALKYRYDKIADKHKRPQQP 161

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
           PQPA T Y+ +A  E+P   G+Y + RY LV+L P TGRKHQLRRH+ H+RHPIIGD+ H
Sbjct: 162 PQPASTMYQSVAKFEVPEPVGKYQSARYSLVKLSPSTGRKHQLRRHMVHIRHPIIGDTTH 221

Query: 182 GDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           GD +QN+   +HF    L L  +Q+  +HP TG+ ++I++ +       L + 
Sbjct: 222 GDGKQNKFAKQHFNFNNLALSCTQMGFSHPVTGKWVSINSQMHSEMRLWLEKL 274


>UniRef50_Q82WZ5 Ribosomal large subunit pseudouridine synthase D n=2
           Tax=Nitrosomonas RepID=RLUD_NITEU
          Length = 344

 Score =  284 bits (728), Expect = 2e-75,   Method: Composition-based stats.
 Identities = 70/237 (29%), Positives = 111/237 (46%), Gaps = 17/237 (7%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG---QHVFTAHRLDRPTS 58
           L+IL++D+ L+ ++KP+G +VH    +    ++                   HRLD+ T+
Sbjct: 109 LKILFEDDHLIIIDKPAGLVVHPGNGNWHGTLLNALLNHAPQLSQVPRAGIVHRLDKDTT 168

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           G+L++  + EA   LA+Q +Q  +++ Y A+V G L ++ V+D P+              
Sbjct: 169 GLLVVAKTIEAQFDLARQLQQRTVKRHYLALVLGKLEKDGVVDAPIGRHPIHRTRMAVV- 227

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
            +  +PA THYR L                  L+    +TGR HQ+R HL  + HP+ GD
Sbjct: 228 -QNGKPARTHYRVLEKFTAS-----------TLLHCSLETGRTHQIRVHLLSIGHPLAGD 275

Query: 179 SKHGDLRQNRSGAEH-FGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
             +G    + S A+    L R  LHA QL LTHP +G+ L   + L D     L   
Sbjct: 276 PVYGRTSPDPSTADAVVRLPRQALHAWQLELTHPHSGQILLWESPLPDDMAALLQAI 332


>UniRef50_A9BFW4 Pseudouridine synthase n=8 Tax=Thermotogaceae RepID=A9BFW4_PETMO
          Length = 319

 Score =  284 bits (727), Expect = 2e-75,   Method: Composition-based stats.
 Identities = 74/241 (30%), Positives = 118/241 (48%), Gaps = 22/241 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRD-----QIGQHVFTAHRLD 54
           L ILY+DE L+ +NKP+G +VH +   +   +V  +M  V+D     Q    +   HRLD
Sbjct: 85  LNILYEDEELIVINKPAGLIVHPTPSIKTGTLVNALMHHVKDLDKTMQDPNRLGIVHRLD 144

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIAD 113
           + TSGVL++  ++ +  LL+++F++ +  K Y AIV G L E E  ++ PL         
Sbjct: 145 KETSGVLVVAKNAFSHHLLSKEFKERKTMKYYLAIVEGTLKEKEGEINLPLGRHPILRHK 204

Query: 114 KFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
           +        + A+T Y+ L                  LV +  +TGR HQ+R H  ++ +
Sbjct: 205 RAVVY--NGKEAITEYKTLKEF----------GDLATLVWIRLRTGRTHQIRVHFKYIGN 252

Query: 174 PIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           P+IGDS +G  +  ++      + R MLHA +L   HP T E +   A L D +   L  
Sbjct: 253 PLIGDSLYGKNKIEKNL--QIPVGRQMLHALKLGFYHPKTKEWMEFLAPLPDDFKNLLIT 310

Query: 234 F 234
            
Sbjct: 311 L 311


>UniRef50_P50513 Ribosomal large subunit pseudouridine synthase D n=8
           Tax=Sphingomonadales RepID=RLUD_ZYMMO
          Length = 317

 Score =  284 bits (727), Expect = 2e-75,   Method: Composition-based stats.
 Identities = 69/241 (28%), Positives = 108/241 (44%), Gaps = 19/241 (7%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG-------QHVFTAHRLD 54
           LEI+++DE L+ VNKP+G +VH +  + D  +V                       HR+D
Sbjct: 82  LEIVFEDEHLLVVNKPAGMVVHPAAGNYDNTLVNALLYHCAGKLSGIGGVARPGIVHRID 141

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADK 114
           + TSG+L++  +  A   LA QF  H I +RY AIV G    +  +D PL          
Sbjct: 142 KDTSGLLVVAKTDPAHAGLAAQFADHSINRRYRAIVDGHPSLQGHVDAPLARSSVNRQKM 201

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
               D   + AVTHYR +            P     L+E   +TGR HQ+R H++ + H 
Sbjct: 202 AIVSDGRGKRAVTHYRMIT-----------PLKNASLIECRLETGRTHQVRVHMSSIGHS 250

Query: 175 IIGDSKHGDLRQ-NRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           ++GD  +G  ++ + +  +    QR  LHA+ L   HP +G+ +   A +          
Sbjct: 251 LLGDPVYGRSKKAHHALLQSLAFQRQALHAAHLGFIHPISGKQVDFDAEMPQDMQLLFKM 310

Query: 234 F 234
            
Sbjct: 311 L 311


>UniRef50_C9KPZ8 Pseudouridine synthase n=1 Tax=Mitsuokella multacida DSM 20544
           RepID=C9KPZ8_9FIRM
          Length = 308

 Score =  283 bits (726), Expect = 3e-75,   Method: Composition-based stats.
 Identities = 76/242 (31%), Positives = 115/242 (47%), Gaps = 22/242 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIGQ----HVFTAHRLDR 55
           L+ILY+D  ++ +NK  G +VH +       +V  ++   +D  G          HRLD+
Sbjct: 80  LDILYEDSDIIVINKARGMVVHPATGIYTGTLVNALLYHCKDLSGINGEIRPGIVHRLDK 139

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKF 115
            TSGV++   +  A   LA+Q       + Y AIV G + EEA +    +        K 
Sbjct: 140 DTSGVMVAAKNDAAHLDLAEQIRTKAAHRIYRAIVCGNIREEAGVIKGDIGRHPTDRKKM 199

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
           A   +  +PAVTH+R L                Y LVE   +TGR HQ+R H+A + HP+
Sbjct: 200 AIVHEHGKPAVTHFRVLERF-----------GAYTLVECRLETGRTHQIRVHMASIGHPV 248

Query: 176 IGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFG 235
           +GD K+G  +     A  F ++   LH+ QL+LTHP T E +T  A L +   + L    
Sbjct: 249 LGDPKYGPRK-----ACPFAIKGQALHSLQLTLTHPRTREVMTFTAPLPEDMEKILKALR 303

Query: 236 WR 237
            +
Sbjct: 304 AK 305


>UniRef50_Q31IZ8 Pseudouridine synthase n=2 Tax=Proteobacteria RepID=Q31IZ8_THICR
          Length = 252

 Score =  283 bits (725), Expect = 4e-75,   Method: Composition-based stats.
 Identities = 114/237 (48%), Positives = 153/237 (64%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
            +ILYQD+ LVAV+KP+G LVHRS +DR E    +Q  RDQI Q V+  HRLD+ TSG+L
Sbjct: 10  FKILYQDDSLVAVHKPAGLLVHRSPIDRHETQFAVQMTRDQINQKVYPLHRLDKATSGLL 69

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKG 121
           L  L S   RL+ QQFE+H IQK Y AI RGW  E   +D+ L  +LDK+ D+ A+ +K 
Sbjct: 70  LFALDSNTARLMGQQFEEHTIQKHYLAICRGWTAEHGEIDHALKHKLDKLGDRHAQTNKP 129

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
           PQ A+T++  LAT ++    G++ + RY LV+L PKTGRKHQLRRHL H+ HPIIGD K+
Sbjct: 130 PQEALTNFERLATTDVMHKIGKFDSQRYSLVKLMPKTGRKHQLRRHLNHISHPIIGDVKY 189

Query: 182 GDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWRG 238
           GD   N       G  RL L A+ L+  HP T   +T++A L+ ++ +A     W+ 
Sbjct: 190 GDRHHNHFFNTWLGQHRLYLAATSLTFNHPQTNARMTLNAPLELSYQKATQHLNWQE 246


>UniRef50_A7NB61 Pseudouridine synthase n=18 Tax=Francisella RepID=A7NB61_FRATF
          Length = 332

 Score =  283 bits (724), Expect = 6e-75,   Method: Composition-based stats.
 Identities = 56/238 (23%), Positives = 109/238 (45%), Gaps = 16/238 (6%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIG-QHVFTAHRLDRPTS 58
           L+I+++D+ ++ ++KP   +VH    +    V   ++   +DQ         HRLD+ TS
Sbjct: 88  LKIIFEDDDIIVIDKPVNMIVHPGAGNPTGTVSNALLHRYKDQDKLPRAGIVHRLDKDTS 147

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           G+++   SS A   L QQ  + ++ ++Y AIV G + ++  ++ P+  +           
Sbjct: 148 GLMVAAKSSIAYHNLVQQLAERKVSRKYLAIVEGEIYQQGTINQPIGRDPTNRTKMAINY 207

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
               + A+T+Y  +   +            + L+E + +TGR HQ+R H+  ++HP++GD
Sbjct: 208 R--GKEAITYYTPIEVYD-----------GFTLIECQLETGRTHQIRVHMKSIKHPLVGD 254

Query: 179 SKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGW 236
             +                R  LHA +LS  HP T + +   + L +  +   +Q   
Sbjct: 255 QTYNKSSTKLEKLAITIPTRQALHAYKLSFIHPTTAKMVKFKSKLPEDMLNLKAQLEQ 312


>UniRef50_A3EQJ0 Pseudouridine synthase n=1 Tax=Leptospirillum rubarum
           RepID=A3EQJ0_9BACT
          Length = 339

 Score =  282 bits (723), Expect = 7e-75,   Method: Composition-based stats.
 Identities = 73/252 (28%), Positives = 113/252 (44%), Gaps = 36/252 (14%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQI------------------ 43
           LEILY+DE L+ ++KP G +VH +       +V       Q                   
Sbjct: 95  LEILYEDEDLIVISKPPGLVVHPAPGHSSGTLVNGLLFHFQSQGDEQKKGEPEEEEEAER 154

Query: 44  GQHVFTAHRLDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDY 102
                  HRLD+ TSGV+++G +      L  QF+   + K+Y A+V+G L ++   ++ 
Sbjct: 155 PLRAGLVHRLDQDTSGVMVVGKTESVVLDLMNQFKDRSVSKKYLALVKGILPKKRGEINA 214

Query: 103 PLVEELDKIADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKH 162
           P+            R+D   +P+VT YR L T              Y L+E+   TGR H
Sbjct: 215 PIGRSTHDRKKFTVRQD--GKPSVTRYRVLETYHE----------NYSLLEVTLLTGRTH 262

Query: 163 QLRRHLAHLRHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAG 222
           Q+R H  +L  P++GD+ +G       G E+    R MLHA +LS  HP +   +   A 
Sbjct: 263 QIRVHFRYLGFPLLGDAVYGSK-----GTENKNFPRQMLHAWKLSFQHPSSNSKMEFEAP 317

Query: 223 LDDTWMQALSQF 234
           L   ++ AL + 
Sbjct: 318 LPPDFVSALERL 329


>UniRef50_A9IQ66 Pseudouridine synthase n=5 Tax=Bacteria RepID=A9IQ66_BART1
          Length = 334

 Score =  282 bits (722), Expect = 9e-75,   Method: Composition-based stats.
 Identities = 68/254 (26%), Positives = 117/254 (46%), Gaps = 25/254 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG-------QHVFTAHRLD 54
           L+ILY+D+ ++ +NKP+G +VH    +    +V                 +     HRLD
Sbjct: 81  LDILYEDDHVIVINKPAGLVVHPGNGNWTGTLVNALIYHCGNSLSGIGGVKRPGVVHRLD 140

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQH----QIQKRYHAIVRGWLMEEA-VLDYPLVEELD 109
           + TSGV+++  +  A + L+ QF  H     + +RYHA++ G        +D  L     
Sbjct: 141 KNTSGVMVVAKNDLAHKSLSAQFSDHGRTCALDRRYHALIWGTPHRNVWTIDASLGRSPH 200

Query: 110 KIADKFAREDKGP--QPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRH 167
               +     + P  + AVTH+  L        +  +      L+E   +TGR HQ+R H
Sbjct: 201 NRTKQAVVHKQTPHARHAVTHFSLLEKYGTHADSTSFA----SLLECRLETGRTHQIRVH 256

Query: 168 LAHLRHPIIGDSKHGDLRQNRSGAEHFGLQ-------RLMLHASQLSLTHPFTGEPLTIH 220
           +AH+ HP+IGD+ +G+  + +S   +  L+       R  LHA+ L+  HP +G+ ++  
Sbjct: 257 MAHIGHPLIGDTVYGNAFKTKSNTLNPTLKNAIDQFNRHALHAASLTFEHPSSGKVISFS 316

Query: 221 AGLDDTWMQALSQF 234
           A L     Q +   
Sbjct: 317 APLPQDMAQLIKHL 330


>UniRef50_A7HM17 Pseudouridine synthase n=2 Tax=Thermotogaceae RepID=A7HM17_FERNB
          Length = 314

 Score =  281 bits (721), Expect = 1e-74,   Method: Composition-based stats.
 Identities = 67/240 (27%), Positives = 115/240 (47%), Gaps = 21/240 (8%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIGQ----HVFTAHRLDR 55
           L+I+Y+D  ++ +NK  G + H         +V  V+   +D  G          HRLD+
Sbjct: 79  LDIIYEDRDILVINKQPGIITHPIPSHTSGTIVNGVLYHCKDLQGIGGVLRPGIVHRLDK 138

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADK 114
            TSGV+++  +  A + L +QF+    +K Y  +V+G    +E  ++  +          
Sbjct: 139 DTSGVMVIAKNDLAHQSLTKQFKDRLTEKLYICLVKGVPKRKEGDIEINIARNPVLRVKM 198

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
                +  +PA+THY+ +                  LV   PKTGR HQ+R H+ ++ HP
Sbjct: 199 TVTNSEYGKPALTHYKVVREF----------GDIAALVFAYPKTGRTHQIRVHMKYIGHP 248

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           ++GD  +G  +++    E FG++R MLHA  LS  HP TGE +   A +   + +A+ + 
Sbjct: 249 LMGDEVYGRAKED----EIFGIKRQMLHALSLSFYHPRTGEKVKFIAKIPQDFKEAIQKL 304


>UniRef50_Q9JVB6 Ribosomal large subunit pseudouridine synthase D n=39
           Tax=Proteobacteria RepID=RLUD_NEIMA
          Length = 374

 Score =  280 bits (718), Expect = 2e-74,   Method: Composition-based stats.
 Identities = 63/248 (25%), Positives = 110/248 (44%), Gaps = 19/248 (7%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG---QHVFTAHRLDRPTS 58
           L+I+Y+D+ ++ VNKP+G +VH +  +    ++                   HRLD+ TS
Sbjct: 105 LDIVYEDDTVIVVNKPAGLVVHPAAGNWTGTLLNGLLAHCPELSQIPRAGIVHRLDKETS 164

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           G++++  +  A   L  Q ++  +++ Y A+  G +  +  ++  +  +      K A  
Sbjct: 165 GLMVVAKTLPAQNSLVWQLQERTVKRIYRAVANGIVPFDGKIETQIGRDPHN-RLKMAVV 223

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
             G +PAVTH + L                +  +E   +TGR HQ+R H+    HP+ GD
Sbjct: 224 KFGGKPAVTHVKVLERYLA-----------HSYIECSLETGRTHQIRVHMREANHPLAGD 272

Query: 179 SKHGDLRQNRSGAEHFGLQ----RLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
             +G+ R          ++    R  LHA +LS THP +GE ++  A + D     LS  
Sbjct: 273 PVYGNPRHPCGDTVKEAVKSLGARQALHAYRLSFTHPESGETVSFEAPIPDDIYHLLSVL 332

Query: 235 GWRGLLPE 242
                L  
Sbjct: 333 RLEAGLDS 340


>UniRef50_A4BJ00 Pseudouridine synthase n=1 Tax=Reinekea blandensis MED297
           RepID=A4BJ00_9GAMM
          Length = 249

 Score =  279 bits (716), Expect = 4e-74,   Method: Composition-based stats.
 Identities = 107/240 (44%), Positives = 145/240 (60%), Gaps = 5/240 (2%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQI-----GQHVFTAHRLDRP 56
           L I+Y+D+ L+ V+KPSG L+H SWLDR E   +    +  +     G  V T HRLDRP
Sbjct: 4   LNIVYEDDVLLVVDKPSGLLMHPSWLDRRETDTLAGRAKAYLAQQSEGAKVHTVHRLDRP 63

Query: 57  TSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFA 116
           TSG+++M     A + L +QF++  + KRY AI RG+      LDYPL+EE D+IADKFA
Sbjct: 64  TSGLVVMCKDDHAAKALVEQFQEKTVNKRYWAICRGFAPVAETLDYPLIEEHDRIADKFA 123

Query: 117 REDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPII 176
             DK  Q A+T +R L   E+ +   RYP  R   +E  P TGRKHQ+RRHL HLR+PI+
Sbjct: 124 DSDKPAQEAITEFRRLGITELAIPVSRYPKMRLSWMECVPVTGRKHQIRRHLKHLRYPIL 183

Query: 177 GDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGW 236
           GD++HG    NR+    FG   + L A ++S  HP T E +T + G D+ W   L + GW
Sbjct: 184 GDTRHGCRHLNRAVEGSFGELFMGLRAVEMSFQHPVTNELMTFNVGADNVWSCWLDRLGW 243


>UniRef50_B8FT16 Pseudouridine synthase n=70 Tax=Bacteria RepID=B8FT16_DESHD
          Length = 334

 Score =  279 bits (716), Expect = 4e-74,   Method: Composition-based stats.
 Identities = 75/240 (31%), Positives = 119/240 (49%), Gaps = 25/240 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIGQ----HVFTAHRLDR 55
           LEILY+DE ++ VNK  G +VH +     + +V  ++   R+  G          HR+D+
Sbjct: 107 LEILYEDEDVLVVNKSQGMVVHPAPGAWTKTLVNALLYHCRNLSGINGVLRPGIVHRIDK 166

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADK 114
            TSG+L++  +  A + LA+Q + H + +RY AIV G + E    ++ P+  +      K
Sbjct: 167 DTSGLLVVAKNDLAHQGLAEQIKAHSMARRYLAIVHGVVFEPSGTVEAPIGRDPAD-RKK 225

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
            A   +  + AVTHY  L                + L+E   +TGR HQ+R H+A+L+HP
Sbjct: 226 MAVVFQNAKEAVTHYEVLERFR-----------DFTLLEARLETGRTHQIRVHMAYLKHP 274

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           ++GD  +G  +        FGLQ  MLHA  L   HP +GE +   A     + + L + 
Sbjct: 275 VLGDPLYGPRK------NPFGLQGQMLHAQLLGFQHPRSGEYMEFSAPASGMFQKVLEEI 328


>UniRef50_A1U2H1 Pseudouridine synthase n=1 Tax=Marinobacter aquaeolei VT8
           RepID=A1U2H1_MARAV
          Length = 245

 Score =  279 bits (716), Expect = 5e-74,   Method: Composition-based stats.
 Identities = 116/232 (50%), Positives = 153/232 (65%), Gaps = 3/232 (1%)

Query: 5   LYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRD-QIGQHVFTAHRLDRPTSGVLLM 63
           +Y+D+WL+AV+KP+G LVHRS +D+ E    +Q  R    G+HV+  HRLDRPTSGVLL 
Sbjct: 8   IYRDDWLLAVHKPAGLLVHRSPIDKHETEFALQYARAMNGGEHVYPVHRLDRPTSGVLLF 67

Query: 64  GLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKGPQ 123
               E  R L        + K Y A+VRGW  E+ V+D+PL EE +    K   +++  +
Sbjct: 68  ARDPETARALGLAMMAGAVSKTYLAMVRGWAPEQGVIDHPLREEPEDRRLKG--QEQPVR 125

Query: 124 PAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHGD 183
            A+T YR LAT E+PVA  RYPT+RY LVEL+P+TGRKHQLRRH+ H+ HPIIGD+ HG 
Sbjct: 126 EALTRYRRLATTELPVAIERYPTSRYSLVELKPETGRKHQLRRHMKHINHPIIGDANHGR 185

Query: 184 LRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFG 235
            R NR  AE FG  RLML A++L L HP T EPL + A  + +++Q L+ F 
Sbjct: 186 GRHNRYFAERFGQGRLMLAATELRLRHPVTDEPLCLKAHPESSFLQVLAIFE 237


>UniRef50_B9JRD0 Pseudouridine synthase n=1 Tax=Agrobacterium vitis S4
           RepID=B9JRD0_AGRVS
          Length = 342

 Score =  278 bits (713), Expect = 1e-73,   Method: Composition-based stats.
 Identities = 73/253 (28%), Positives = 117/253 (46%), Gaps = 24/253 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIG-----QHVFTAHRLD 54
           L +LY+D+ L+ ++KP+G +VH    +    +V  ++    D +      +     HRLD
Sbjct: 90  LTVLYEDKDLIVLSKPAGLVVHPGAGNWTGTLVNALIHHCGDSLSGIGGVKRPGIVHRLD 149

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQ----IQKRYHAIVRGWLME-EAVLDYPLVEELD 109
           + TSGV+++  +  A R LA QF  H     +++ Y A+V G        +D  L    D
Sbjct: 150 KETSGVMVVAKNDIAHRHLADQFADHGRSGPLERAYQALVWGRPRGLRGTIDAALGRAGD 209

Query: 110 KIADKFARED-KGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHL 168
           +      RED    + A+THY+ +             T    LVE   +TGR HQ+R H+
Sbjct: 210 RTKRTVKREDTDDAREAITHYQVMERYGEKPD----ATCLASLVECRLETGRTHQIRVHM 265

Query: 169 AHLRHPIIGDSKHG-------DLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHA 221
           AH+ HP+IGD ++G       +L  + + A      R  LHA  L+  HP TG+ +   A
Sbjct: 266 AHIGHPLIGDPEYGAAFKTKANLLPDAAKAIVTNFHRQALHAYLLAFEHPTTGDVMHFAA 325

Query: 222 GLDDTWMQALSQF 234
            + D     +   
Sbjct: 326 PIPDDMETIIRAL 338


>UniRef50_Q8XYX8 Ribosomal large subunit pseudouridine synthase D n=94
           Tax=Proteobacteria RepID=RLUD_RALSO
          Length = 358

 Score =  278 bits (713), Expect = 1e-73,   Method: Composition-based stats.
 Identities = 64/242 (26%), Positives = 111/242 (45%), Gaps = 15/242 (6%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG---QHVFTAHRLDRPTS 58
           L+++Y+D+ L+ +NKP+G +VH +  +    V+     R             HRLD+ TS
Sbjct: 116 LDVVYEDDTLLVINKPAGLVVHPAAGNWSGTVLNGLLHRYPQAAGLPRAGIVHRLDKETS 175

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           G++++  +  A   L +Q +   +++ Y A+V G   E   +D P+  +          E
Sbjct: 176 GLMVVARTLPAQTDLVRQLQARTVKRTYLALVWGETPEAGTIDAPIGRDPRDRTRMAIIE 235

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
               +PA TH++ L  V++  A       +  LV+ + +TGR HQ+R H     HP++GD
Sbjct: 236 TASGKPARTHFKTLDVVDLGRA-------QVSLVQCQLETGRTHQIRVHFESEGHPLLGD 288

Query: 179 SKHG-----DLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
             +         Q           R  LHA +L L HP +G+ +  HAG+ D   + +  
Sbjct: 289 PVYTRNFRRGRPQTIKAPLPAPFARQALHAVRLGLVHPASGQSVHWHAGVPDDLAELMDA 348

Query: 234 FG 235
             
Sbjct: 349 LE 350


>UniRef50_A6VXE8 Pseudouridine synthase n=2 Tax=Marinomonas RepID=A6VXE8_MARMS
          Length = 242

 Score =  278 bits (712), Expect = 1e-73,   Method: Composition-based stats.
 Identities = 102/236 (43%), Positives = 145/236 (61%), Gaps = 1/236 (0%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           L+IL+QDE LVAVNKP+G LVHR+ L +DE+  V+Q +RDQ G+ VF  HRLDR TSGVL
Sbjct: 3   LDILFQDEHLVAVNKPAGLLVHRTNLAKDEEDAVVQRLRDQTGKWVFPVHRLDRGTSGVL 62

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKG 121
           +M  S E  R L+ QF + + QK YH +VRG+  E  V++YPL +  ++      + +  
Sbjct: 63  VMAFSPEVARRLSTQFAESKTQKTYHCLVRGYCNESGVINYPLAKLNEQKGRSRFKIEGT 122

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
            + A T +  L   ++PV   RY + R   +E+ PK GRKHQ+RRH  H  +P++GDS +
Sbjct: 123 EREAETGFTRLIQYQLPVPVSRYDSMRLSWLEVTPKQGRKHQIRRHFKHHLNPLVGDSCY 182

Query: 182 GDLRQNRSGAEHFGLQ-RLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGW 236
           G    N+   E +    RLMLHAS L   HP T +P+T+ A L D  +  L++  +
Sbjct: 183 GCRHINKVAKELWSEDFRLMLHASSLEFNHPITNQPITLKADLSDKIINILNKLEY 238


>UniRef50_C8QZ10 Pseudouridine synthase n=1 Tax=Desulfurivibrio alkaliphilus AHT2
           RepID=C8QZ10_9DELT
          Length = 324

 Score =  278 bits (711), Expect = 2e-73,   Method: Composition-based stats.
 Identities = 76/237 (32%), Positives = 116/237 (48%), Gaps = 21/237 (8%)

Query: 5   LYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIGQ----HVFTAHRLDRPTS 58
           LY+DE ++ + KP G +VH +   R   +V  ++   R+  G          HRLD+ TS
Sbjct: 96  LYEDEDILVLVKPPGLVVHPADGHRQGTLVHGLLHHCRNLSGISGQLRPGIVHRLDKDTS 155

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADKFAR 117
           G L++  +  A   L QQF+  +++K Y A++RG L E+   +  P+         K A 
Sbjct: 156 GCLVVAKNDLAHHNLVQQFKGREVEKTYQALLRGILAEDTGQVVLPIGRHPVH-RKKMAV 214

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
             +G + AVTH+R               +  Y LVEL  +TGR HQ+R H+A L HP+ G
Sbjct: 215 RREGGREAVTHWRVRQRF----------SAGYTLVELLLETGRTHQIRVHMAALGHPLAG 264

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           D  +G   +N      +G+ R  LHA +L+  HP +G  LT  A L      +L + 
Sbjct: 265 DRLYG---RNPEKDMPYGIDRQWLHAWRLAFNHPRSGRRLTFTAPLWVDLQASLDRL 318


>UniRef50_Q1N5G6 Pseudouridine synthase n=1 Tax=Bermanella marisrubri
           RepID=Q1N5G6_9GAMM
          Length = 236

 Score =  278 bits (711), Expect = 2e-73,   Method: Composition-based stats.
 Identities = 109/234 (46%), Positives = 147/234 (62%), Gaps = 7/234 (2%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLM 63
           ILYQD+ L+A+NKPSG LVH+SW+ +D K   +Q VRD  G+HVF  HRLDRPTSGVLL 
Sbjct: 9   ILYQDDDLIAINKPSGLLVHKSWVAKDAKEFALQIVRDMSGKHVFPVHRLDRPTSGVLLF 68

Query: 64  GLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKGPQ 123
           G S E  + +  Q+E  Q  K Y A+VRGWL E+ ++D+ L    D     + ++ +  Q
Sbjct: 69  GFSGEIAQQVQAQWE--QANKTYWAVVRGWLKEQTLVDHALKGMAD-----YGQDVEIVQ 121

Query: 124 PAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHGD 183
            A TH++ +  VE+     RYP +R+  VE +PK GR HQ+RRHL HL HPIIGD+++G 
Sbjct: 122 EAQTHFKPIDYVEIDAEIDRYPKSRFSWVEAKPKQGRTHQIRRHLKHLSHPIIGDARYGK 181

Query: 184 LRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWR 237
            + NR   EH+   RL+LH  QL +THP +G  L I A L+       S F W+
Sbjct: 182 GKYNRYITEHYDCPRLLLHHQQLEMTHPVSGSKLMITAPLEGAMQSLFSTFDWK 235


>UniRef50_B8FLB4 Pseudouridine synthase n=2 Tax=Bacteria RepID=B8FLB4_DESAA
          Length = 321

 Score =  277 bits (710), Expect = 2e-73,   Method: Composition-based stats.
 Identities = 77/245 (31%), Positives = 114/245 (46%), Gaps = 23/245 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIG----QHVFTAHRLDR 55
           L ILY+D  +VAVNKP G +VH +       +V  ++   +D  G    Q     HRLD+
Sbjct: 83  LAILYEDRDIVAVNKPPGMVVHPAPGHSSNTLVNALLAHCKDLSGIGGVQRPGIVHRLDK 142

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADK 114
            TSGV+L   +  A   L++Q  Q +++K Y A+  G + E+  V+D PL          
Sbjct: 143 ETSGVILAAKNDAAHAGLSEQLAQRRVEKFYLALAHGVIKEDTGVIDLPLARHPSDRKRM 202

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
                   + A++ +                      V+++ KTGR HQ+R HLA L HP
Sbjct: 203 HVSTPAKGREALSLWTVKERF-----------LDATYVKVQIKTGRTHQIRVHLAALHHP 251

Query: 175 IIGDSKHGDLRQNRSGA-----EHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQ 229
           +IGD+ +G  ++          +    +R MLHA  +S THP TGE LT+ A L     Q
Sbjct: 252 VIGDTVYGGRKKRGRLPASVLGKAPPPERQMLHAHIVSFTHPVTGEKLTLTAPLPQDMAQ 311

Query: 230 ALSQF 234
            L   
Sbjct: 312 LLEAL 316


>UniRef50_B2A2J2 Pseudouridine synthase n=1 Tax=Natranaerobius thermophilus
           JW/NM-WN-LF RepID=B2A2J2_NATTJ
          Length = 328

 Score =  277 bits (710), Expect = 2e-73,   Method: Composition-based stats.
 Identities = 62/241 (25%), Positives = 114/241 (47%), Gaps = 20/241 (8%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQ------IGQHVFTAHRLDR 55
           L+I+Y+DE+L+ VNKP   +VH    +  + +V       Q        +     HRLD+
Sbjct: 91  LDIVYEDEYLLVVNKPRNMVVHPGAGNYRDTMVNALLYHCQNLSDGTSYERPGIVHRLDK 150

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADK 114
            TSG+L++   +E   +L+++ +  ++ + Y A+V G    ++A +D P+  +       
Sbjct: 151 DTSGLLVVAKQNETHDILSEEIKNRRVARTYLALVIGDFSKKKATIDLPIGRDPRNRKKM 210

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
                 G + A+T    L + + P         +   ++   +TGR HQ+R HL+HL +P
Sbjct: 211 AVVH--GGKRAITKVEMLRSFQNPE--------KISYLKCSLETGRTHQIRVHLSHLGYP 260

Query: 175 IIGDSKH-GDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           ++GD  + G   +N    ++  L    LH+  L+ THP   + +   A L    M  +S+
Sbjct: 261 LLGDPVYRGKTGKNVDIDKN--LTGQALHSFSLAFTHPVFKKTMVFRAPLPSDMMNLISK 318

Query: 234 F 234
            
Sbjct: 319 L 319


>UniRef50_B8CWM0 Pseudouridine synthase n=1 Tax=Halothermothrix orenii H 168
           RepID=B8CWM0_HALOH
          Length = 308

 Score =  276 bits (707), Expect = 5e-73,   Method: Composition-based stats.
 Identities = 67/243 (27%), Positives = 118/243 (48%), Gaps = 25/243 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQ-TVRDQIG-----QHVFTAHRLDR 55
           L+I+Y+D+ ++ +NK +G +VH +  + +  +V       D +            HRLD+
Sbjct: 82  LDIIYEDKDILVLNKNAGLVVHPAPGNHENTLVNALIAYCDNLSTISGVNRPGIVHRLDK 141

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADK 114
            TSGV+++  +  + R L +QF+Q + +K Y  +++G L  +E  +D P+  +      K
Sbjct: 142 DTSGVMVIAKNDISHRKLVEQFKQRKTKKYYRTLLKGELPYKEGKIDAPIGRDPHD-RKK 200

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
            A   K  + AVT+++ L                +  VE+E KTGR HQ+R H +++  P
Sbjct: 201 MAVTRKNSKKAVTYFKVLEFFR-----------DHSYVEVELKTGRTHQIRVHFSYMGFP 249

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           ++GDS +G  R            R +LHA +L   HP   + +   A L D + +AL   
Sbjct: 250 VVGDSIYGKKR------NRLQATRQLLHAYRLGFYHPRNDKWVEYKASLPDDFKKALDIL 303

Query: 235 GWR 237
             +
Sbjct: 304 ENK 306


>UniRef50_B4RVP9 Pseudouridine synthase n=1 Tax=Alteromonas macleodii 'Deep ecotype'
           RepID=B4RVP9_ALTMD
          Length = 265

 Score =  276 bits (707), Expect = 5e-73,   Method: Composition-based stats.
 Identities = 115/233 (49%), Positives = 150/233 (64%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           L +LYQDE ++A++KP G LVHRS +D+ E V  +QT+RDQIGQHVF AHRLDRPTSGVL
Sbjct: 28  LPVLYQDEHIIAIDKPPGLLVHRSPIDKHETVFAVQTLRDQIGQHVFPAHRLDRPTSGVL 87

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKG 121
           +   S++    L +Q    Q+ K+YHAIVRG++     +DY L    DKIADK  R  + 
Sbjct: 88  VFSFSADTAAKLGKQMMDKQVVKQYHAIVRGFVHHTGYIDYALKYRYDKIADKHKRPQQP 147

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
           PQPA T Y  LA  ++P   GRY + RY LV L P TGRKHQLRRH+ H+RHPIIGD+ H
Sbjct: 148 PQPASTMYESLAKFDVPEPVGRYQSARYSLVRLSPSTGRKHQLRRHMVHIRHPIIGDTTH 207

Query: 182 GDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           GD +QN+    HF    L L  +Q+  +HP T + +TI+  +     Q   + 
Sbjct: 208 GDGKQNKFAKSHFNFTHLALSCTQMGFSHPVTQKWITINGEMHSEMRQFTDRL 260


>UniRef50_D2L0S2 Pseudouridine synthase, RluA family n=1 Tax=Desulfovibrio sp.
           FW1012B RepID=D2L0S2_9DELT
          Length = 558

 Score =  276 bits (707), Expect = 6e-73,   Method: Composition-based stats.
 Identities = 82/269 (30%), Positives = 119/269 (44%), Gaps = 28/269 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQT-----VRDQIGQHVFTAHRLDRP 56
           L +LY D+ L  ++KP G  VH +    +  +V         +R+  G+     HRLD+ 
Sbjct: 91  LRVLYADKELAVLDKPPGLTVHPAPGLPEGTLVNRLLHHFPGLREMAGERPGIVHRLDKD 150

Query: 57  TSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAV-LDYPLVEELDKIADKF 115
           TSG+L++ L+      LA  F   Q+ K Y A+V G    +   +  P+  +  K   K 
Sbjct: 151 TSGLLMVALTEPVRLALAADFAARQVHKTYLALVHGRPDGKGGDIRLPIGRDP-KYRTKM 209

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
           A   KG +PA + +R + T          P     L+E+   TGR HQ+R H+A + HPI
Sbjct: 210 AVPHKGGRPAHSRWRPVWTA---------PDGTASLLEVTIFTGRTHQIRVHMAAIGHPI 260

Query: 176 IGDSKHGDLRQ----NRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
           IGD+ +G  +      R GA      R MLHA +LS THP   EP +        +    
Sbjct: 261 IGDAVYGPHQHAAWKRRGGAIARLASRQMLHAWKLSFTHPVLKEPRSFTCPPPPDF---- 316

Query: 232 SQFGWRGLLPENERVEFSAPSGQDGEISS 260
               WR LL    R +     G  G   S
Sbjct: 317 ----WRLLLLLGRRCQRIGVVGMPGCGKS 341


>UniRef50_Q1MQ60 Pseudouridylate synthases, 23S RNA-specific n=1 Tax=Lawsonia
           intracellularis PHE/MN1-00 RepID=Q1MQ60_LAWIP
          Length = 541

 Score =  275 bits (705), Expect = 9e-73,   Method: Composition-based stats.
 Identities = 69/242 (28%), Positives = 110/242 (45%), Gaps = 20/242 (8%)

Query: 1   MLEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQT-----VRDQIGQHVFTAHRLDR 55
            LEIL+ DE L  +NKP G  VH +   ++  +V         + +Q G      HR+D+
Sbjct: 82  FLEILFSDEHLAIINKPPGLTVHPAPSCQESTLVHRLLKYFPKLIEQGGLRPGIVHRIDK 141

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKF 115
            TSG+L + L+ +    L++ F   +I K Y A+V G    E  +  PL  +        
Sbjct: 142 DTSGLLCIALTEDTRLKLSKIFLDRKINKEYLALVHGVPSMEGYIAVPLGRDPKTKVK-- 199

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
              +   +PA T +R L   +  V         Y ++ L  +TGR HQ+R H+ H+ HP+
Sbjct: 200 VAVNPKGKPAHTEWRVLHRGKNDV---------YSILALTIQTGRTHQIRVHMKHIGHPL 250

Query: 176 IGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFG 235
           +GD  +     N++    F   R MLHA +LS  HP TG+ +         ++  +S   
Sbjct: 251 VGDKLYAGGHVNKT----FQCNRQMLHAWKLSFEHPITGKKMNFLCPPPKDFLDTVSLLE 306

Query: 236 WR 237
             
Sbjct: 307 QE 308


>UniRef50_B6AN83 Pseudouridine synthase n=2 Tax=Leptospirillum RepID=B6AN83_9BACT
          Length = 340

 Score =  275 bits (704), Expect = 1e-72,   Method: Composition-based stats.
 Identities = 71/252 (28%), Positives = 113/252 (44%), Gaps = 36/252 (14%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQI------------------ 43
           LEILY+D+ L+ ++KP G +VH +       +V       Q                   
Sbjct: 95  LEILYEDDDLIVISKPPGLVVHPAPGHASGTLVNGLLFHFQSQGDEQKKGEPEEEEEAER 154

Query: 44  GQHVFTAHRLDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDY 102
                  HRLD+ TSGV+++G S      L  QF+   + K+Y A+V+G L ++   ++ 
Sbjct: 155 PLRAGLVHRLDQDTSGVMVVGKSETVVLDLMNQFKDRSVSKKYLALVKGILPKKRGEINA 214

Query: 103 PLVEELDKIADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKH 162
           P+            R+D   +P++T YR L T              Y L+E+   TGR H
Sbjct: 215 PIGRSTHDRKKFAVRQD--GKPSLTRYRVLETYHE----------NYSLLEVTLLTGRTH 262

Query: 163 QLRRHLAHLRHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAG 222
           Q+R H  HL  P++GD+ +G       G E+    R MLHA +L+  HP +   +   A 
Sbjct: 263 QIRVHFRHLGFPLLGDAVYGSK-----GMENRNFPRQMLHAWKLAFQHPRSAAKMEFEAP 317

Query: 223 LDDTWMQALSQF 234
           L   ++ A+ + 
Sbjct: 318 LPPDFVSAMKRL 329


>UniRef50_A1URK8 Pseudouridine synthase n=2 Tax=Bartonella RepID=A1URK8_BARBK
          Length = 336

 Score =  274 bits (703), Expect = 2e-72,   Method: Composition-based stats.
 Identities = 64/254 (25%), Positives = 113/254 (44%), Gaps = 25/254 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG-------QHVFTAHRLD 54
           L IL++D+ ++ VNKP+G +VH    +    +V                 +     HRLD
Sbjct: 80  LHILFEDDHIIVVNKPAGLVVHPGHGNWTGTLVNALIYHCGDSLSGIGGVRRPGIVHRLD 139

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQ----IQKRYHAIVRGWLMEE-AVLDYPLVEELD 109
           + TSGV+++  +  A + L+ QF  H     + +RYHA++ G       V+   L     
Sbjct: 140 KNTSGVIVVAKNDLAHKGLSAQFSDHGRTGVLDRRYHALIWGSPNRNIGVITASLGRARY 199

Query: 110 KIADKFAREDKG--PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRH 167
               +          + AVTH+  +   +       +      L+E   +TGR HQ+R H
Sbjct: 200 DRTKQAVIHSHNIYARHAVTHFSVIEKYQTCADKIPFA----SLLECRLETGRTHQIRVH 255

Query: 168 LAHLRHPIIGDSKHGDLRQNRSGAEHFGLQ-------RLMLHASQLSLTHPFTGEPLTIH 220
           +AH+ HP++GD+ +G+  + +S      ++       R  LHA+ L+  HP  G  ++  
Sbjct: 256 MAHIGHPLVGDTVYGNAFKTKSNRFDSTIKEAIDLFNRQALHAASLTFEHPAKGNIMSFS 315

Query: 221 AGLDDTWMQALSQF 234
           A L     + ++ F
Sbjct: 316 APLPQDMAELINHF 329


>UniRef50_D2QPA6 Pseudouridine synthase n=1 Tax=Spirosoma linguale DSM 74
           RepID=D2QPA6_9SPHI
          Length = 244

 Score =  274 bits (702), Expect = 2e-72,   Method: Composition-based stats.
 Identities = 111/233 (47%), Positives = 143/233 (61%), Gaps = 6/233 (2%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           L ILYQD  LVA+NKP G LVHRS +  D     +Q +RDQ+GQ V+  HRLDR T+GVL
Sbjct: 11  LSILYQDTELVAINKPHGLLVHRSMIASDASEFAVQLLRDQLGQRVYPVHRLDRKTAGVL 70

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKG 121
           L  LS     ++ QQF +  +QK Y AIVRG+  +E  +DYPL ++    A         
Sbjct: 71  LFALSESMNAIMQQQFMEGAVQKTYLAIVRGYTPDELTIDYPLCKDDGNGAVGVL----- 125

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
            Q AVTH + L   E+PVA G++PT+RY LVEL P TGR HQLRRH+AH+ HPIIGD  H
Sbjct: 126 -QEAVTHLKTLRQTEIPVAFGKHPTSRYSLVELTPTTGRMHQLRRHMAHILHPIIGDRPH 184

Query: 182 GDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           G  +QN+   EHF +  ++LHA ++  THP T E  TI A     + + L   
Sbjct: 185 GCNKQNKLFKEHFEMNTMLLHAQRIEFTHPVTQETTTIAAPFQAEFRRMLGVL 237


>UniRef50_A7HV45 Pseudouridine synthase n=56 Tax=Alphaproteobacteria
           RepID=A7HV45_PARL1
          Length = 482

 Score =  274 bits (702), Expect = 2e-72,   Method: Composition-based stats.
 Identities = 66/257 (25%), Positives = 109/257 (42%), Gaps = 32/257 (12%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQ-------IGQHVFTAHRLD 54
           LEI+Y+D  L+ V KP+G +VH +  + D  +V                 +     HRLD
Sbjct: 226 LEIVYEDADLIVVMKPAGLVVHPAPGNPDMTLVNALVAHCGETLSGIGGEKRPGIVHRLD 285

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQH----QIQKRYHAIVRGWL-MEEAVLDYPLVEELD 109
           + TSG++++  +  A + L+ QF  H    ++ + Y A+  G     +  +D  +     
Sbjct: 286 KETSGLMVVAKTDRAHQGLSAQFAAHGRDGKLTRAYTALTWGVPQTRKGTVDANIARSSH 345

Query: 110 KIADKFAREDKG----PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLR 165
             +      D+G     + A+THY              Y       VE   +TGR HQ+R
Sbjct: 346 NRSKMATVRDRGEETGGRIAITHYTV---------KTDYADGLVAEVECRLETGRTHQIR 396

Query: 166 RHLAHLRHPIIGDSKHGDLRQNR-------SGAEHFGLQRLMLHASQLSLTHPFTGEPLT 218
            H+  L HP++GD+ +G   ++R       + A    L R  LHA  L   HP  GE ++
Sbjct: 397 VHMTALGHPLLGDATYGTGMKSRKSKLSPEAQAALERLNRQALHAHHLGFEHPVAGEKMS 456

Query: 219 IHAGLDDTWMQALSQFG 235
             A L +   + +    
Sbjct: 457 FDAPLPEDMQELVRALE 473


>UniRef50_A9BZ16 Pseudouridine synthase n=9 Tax=Burkholderiales RepID=A9BZ16_DELAS
          Length = 319

 Score =  274 bits (702), Expect = 2e-72,   Method: Composition-based stats.
 Identities = 124/270 (45%), Positives = 157/270 (58%), Gaps = 18/270 (6%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           L IL++DE LVAV KP+GWLVHR+ LD  E   V+QT+RDQ+G HV+ AHRLD+ T GVL
Sbjct: 51  LHILWRDEHLVAVYKPAGWLVHRTGLDAHETRFVLQTLRDQLGCHVYPAHRLDKGTCGVL 110

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKG 121
           +M L ++A + L Q F   +++K+Y A+VRGWL +   +D+ L  +        A ED  
Sbjct: 111 VMALHAQAAQRLGQAFAGQEVRKQYLALVRGWLPDAVEVDHALRPDD-------APEDAP 163

Query: 122 PQPAVTHYRGLATVEMPVATG-RYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSK 180
            QPA T  R LA +E P A   R+  TR  LVE  P TGR+HQ+RRHL H+ HPIIGD+ 
Sbjct: 164 AQPAQTSLRCLARLEWPEAFDPRHAATRISLVEALPATGRRHQIRRHLKHVAHPIIGDAT 223

Query: 181 HGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGL--------DDTWMQALS 232
           HG    NR  AE  GLQRL LHA  L L HP TGEPL   A             W    +
Sbjct: 224 HGKGPLNRWWAERLGLQRLWLHAHALELAHPMTGEPLRFEADWRQLGHVADVQHWRALCA 283

Query: 233 QFGWRGL--LPENERVEFSAPSGQDGEISS 260
             GW+    LP   R + +A +G  G   S
Sbjct: 284 LPGWQACAGLPATARPDQTASAGAPGSGCS 313


>UniRef50_B1I3F8 Pseudouridine synthase n=2 Tax=Bacteria RepID=B1I3F8_DESAP
          Length = 309

 Score =  274 bits (702), Expect = 2e-72,   Method: Composition-based stats.
 Identities = 75/240 (31%), Positives = 112/240 (46%), Gaps = 25/240 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIGQ----HVFTAHRLDR 55
           LE+ ++D  ++ VNKP G +VH +       +V  ++   RD  G          HRLDR
Sbjct: 81  LEVCFEDPDVLVVNKPRGLVVHPAVGHYSGTLVNALLHHCRDLSGINGILRPGIVHRLDR 140

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADK 114
            TSG+L++  +  A   LA Q +   + +RY A+V G    E   +D P+     +   +
Sbjct: 141 DTSGLLMVAKNDAAHLALAGQLKDRAVLRRYTALVHGRPRRETGTVDAPIGRHP-RDRQR 199

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
            A   +  + A THYR +   +           ++ L+EL   TGR HQ+R H+AH+ HP
Sbjct: 200 MAVTPRSGRAARTHYRVVRRFD-----------KFSLLELTLDTGRTHQIRVHMAHVGHP 248

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           ++GD K+G  R         GL+   LHA  L   HP TGE L   A L       L + 
Sbjct: 249 LVGDLKYGHARP------ELGLEGQFLHAGTLGFRHPRTGEVLVFEAPLPSELAAVLERL 302


>UniRef50_C1F7V3 Pseudouridine synthase n=1 Tax=Acidobacterium capsulatum ATCC 51196
           RepID=C1F7V3_ACIC5
          Length = 355

 Score =  274 bits (701), Expect = 2e-72,   Method: Composition-based stats.
 Identities = 72/258 (27%), Positives = 122/258 (47%), Gaps = 31/258 (12%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRD-----EKVVVMQTVRDQIGQ------HVFTA 50
           L+I+Y+D+ L+ VNKP+G +VH      D       +V     R +              
Sbjct: 104 LDIIYEDKDLIVVNKPAGMMVHAGSGATDSARNRGTLVNALLGRQEKLSKTGGDLRPGIV 163

Query: 51  HRLDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELD 109
           HRLD+ TSG++++  +  A + LA+ F Q +I K Y A+V G + E+   ++  +  ++ 
Sbjct: 164 HRLDKETSGLIIVARNDAAHQRLAEMFSQREIHKTYLALVHGHIAEDRGTINAAIARDVI 223

Query: 110 KIADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLA 169
           +      R  +G + A++HYR    +E           ++ LV +  +TGR HQ+R HL+
Sbjct: 224 RRTRMTTRRTEGARTAISHYRVQRRIETRW-------GKFTLVSVRIETGRTHQIRVHLS 276

Query: 170 HLRHPIIGDSKHGDL------------RQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPL 217
            + HP++GD+ +G              R+     E   L R  LHA++L   HP + +PL
Sbjct: 277 SIGHPVVGDTHYGAPTTIVLPVANRARRKQLPAPEGLSLPRNFLHAAELKFPHPRSEKPL 336

Query: 218 TIHAGLDDTWMQALSQFG 235
            + A L    +  L Q  
Sbjct: 337 HLEAPLPAELVAFLEQLE 354


>UniRef50_A6SXT6 Pseudouridine synthase n=1 Tax=Janthinobacterium sp. Marseille
           RepID=A6SXT6_JANMA
          Length = 342

 Score =  273 bits (700), Expect = 3e-72,   Method: Composition-based stats.
 Identities = 58/237 (24%), Positives = 108/237 (45%), Gaps = 16/237 (6%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIG-QHVFTAHRLDRPTS 58
           L I+++D  ++ +NKP+G +VH +  +    ++  ++  +    G       HRLD+ TS
Sbjct: 115 LAIVHEDAEMLVINKPAGLVVHPAAGNWSGTLLNGLLHYLPSISGVPRAGIVHRLDKDTS 174

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           G++++  +  A   L +Q +   +++ Y A+V G       +D  +             E
Sbjct: 175 GLMVVAKTLIAHTDLVRQLQARTVKREYLALVWGTPNITGKIDASIGRHARDRIKMAVSE 234

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
           +   +PAVTH++ LAT       G        L+    +TGR HQ+R H+  +   ++GD
Sbjct: 235 NLTAKPAVTHFQRLAT-------GMLDGRPVSLMLCRLETGRTHQIRVHMQSIGFALVGD 287

Query: 179 SKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFG 235
             +G               R  LHA +L L HP +GE +   + L   + + +++ G
Sbjct: 288 GLYGKQHLTTVF------PRQALHARRLGLIHPVSGEAVEWSSELPQDFAELIARAG 338


>UniRef50_B9L028 Pseudouridine synthase n=2 Tax=Thermomicrobia (class)
           RepID=B9L028_THERP
          Length = 322

 Score =  273 bits (698), Expect = 5e-72,   Method: Composition-based stats.
 Identities = 59/239 (24%), Positives = 106/239 (44%), Gaps = 24/239 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQT-----VRDQIGQHVFTAHRLDRP 56
           + ++Y+D+ ++  +KP G + H +       +V         ++ Q        HRLD+ 
Sbjct: 88  IPVIYEDDDIIVFDKPPGIVTHPAPGHEHGTLVNALKAIRPDLQVQPSHRPGIVHRLDKD 147

Query: 57  TSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADKF 115
           TSG+L++  +  A   L +Q++   + K+Y A+V G +  +   +D P+  +  +     
Sbjct: 148 TSGLLVVAKTEAARLALLEQWQSRSVVKKYTALVHGVVEPDSGTIDAPISRDPVERTKMA 207

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
                  +PA+TH+R L                  L+++  +TGR HQ+R H A + HP+
Sbjct: 208 VVS--WGRPAITHFRVLERFRC-----------ATLLDVTIETGRTHQIRVHCAFIGHPV 254

Query: 176 IGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           +GDS++G  R          + R  LHA  L   HP TG+ + +   L       L   
Sbjct: 255 VGDSQYGGHRPF-----CVPVPRQFLHARYLRFVHPTTGQAIELETPLPYDLRTVLEAL 308


>UniRef50_D0MJ49 Pseudouridine synthase n=2 Tax=Bacteria RepID=D0MJ49_RHOM4
          Length = 355

 Score =  273 bits (698), Expect = 5e-72,   Method: Composition-based stats.
 Identities = 70/276 (25%), Positives = 106/276 (38%), Gaps = 54/276 (19%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ---------------- 45
           L+I+Y+D +L+ VNK +G +VH +  +R   +V         G                 
Sbjct: 86  LDIVYEDPYLIVVNKQAGLVVHPARGNRSGTLVNALLYYIGSGPVRFDEEDDLPEDDEIG 145

Query: 46  ----------------HVFTAHRLDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAI 89
                                HRLD+ T+G++++         LA+QFE   I + Y AI
Sbjct: 146 LSMVSTGPTEAKLEAPRPGIVHRLDKDTTGLIVVAKDDVTHTGLARQFEHRTIARTYLAI 205

Query: 90  VRGWL-MEEAVLDYPLVEELDKIADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTR 148
           V G        ++  +  +           D   + AVTHY  +  +             
Sbjct: 206 VWGVPDPPRGRIEAAIGRDPRDRQRMAVVPDDRGKRAVTHYEVVEALPA----------- 254

Query: 149 YGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHGDL--------RQNRSGAEHF--GLQR 198
             LV  + +TGR HQ+R H  H+ HP++GD  +G           + R+  +     L R
Sbjct: 255 AALVRFKLETGRTHQIRVHARHIGHPVLGDPTYGGRTIRYGPHTPRRRAFYDQLFARLTR 314

Query: 199 LMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
             LHA  L   HP TGE L   A L +    AL Q 
Sbjct: 315 QALHAHTLGFRHPRTGEWLEFEAPLPEDMACALEQL 350


>UniRef50_D1ANU4 Pseudouridine synthase n=14 Tax=Fusobacteriaceae RepID=D1ANU4_SEBTE
          Length = 305

 Score =  273 bits (698), Expect = 6e-72,   Method: Composition-based stats.
 Identities = 69/242 (28%), Positives = 120/242 (49%), Gaps = 25/242 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIGQ----HVFTAHRLDR 55
           ++ILY+D  +  ++K +G +VH S       +V  VM  ++D  G          HRLD+
Sbjct: 77  IKILYEDSDIAVIDKEAGIVVHPSHGHESGTLVNAVMYHIKDLSGINGEIRPGIVHRLDK 136

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKF 115
            TSG+L++  +  A   L++ F    I+K Y AI++G + +E+     L+    K   K 
Sbjct: 137 DTSGLLIIAKNDTAHLRLSEMFGSSGIRKTYIAILKGKINKESGKLETLIGRDPKDRKKM 196

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
           A      + A+T+++ L   E           ++ LV++  +TGR HQ+R H+ +L +P+
Sbjct: 197 AVVKTNGKTAITYFQVLDKNE-----------KFSLVKVNIQTGRTHQIRVHMKYLGYPV 245

Query: 176 IGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFG 235
           +GDS +G         ++    R MLHA +L   HP T + + I + L   + +AL + G
Sbjct: 246 LGDSVYG--------RDNKIAGRQMLHAYKLEFLHPVTQKAMKIISELPQDFEKALKETG 297

Query: 236 WR 237
             
Sbjct: 298 LE 299


>UniRef50_B5JL25 Pseudouridine synthase n=1 Tax=Verrucomicrobiae bacterium DG1235
           RepID=B5JL25_9BACT
          Length = 249

 Score =  273 bits (698), Expect = 6e-72,   Method: Composition-based stats.
 Identities = 121/231 (52%), Positives = 152/231 (65%), Gaps = 3/231 (1%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           LEILY+DE LVA++KPSG LVHRS +DR E    +Q +RDQIGQHV+ AHR+DRPTSG+L
Sbjct: 14  LEILYRDERLVAIHKPSGLLVHRSPIDRRETRFAIQLLRDQIGQHVYPAHRIDRPTSGIL 73

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKG 121
           L GL   AG  L+  F+  +IQK Y A+ RG L E  ++D PL +  D      + E   
Sbjct: 74  LFGLDEAAGTALSLLFQNREIQKNYLAVTRGHLPESGLIDSPLHKYEDADGHIKSSET-- 131

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
            Q A T YR LAT E+P  T RY TTRY LVEL P TGR+HQ+RRHLAH+RHPIIGD +H
Sbjct: 132 -QEAETAYRRLATTELPYPTERYDTTRYSLVELTPHTGRRHQIRRHLAHIRHPIIGDVRH 190

Query: 182 GDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALS 232
           G  + N+    HF + RL+L A+ +   HPFT  PL IH   + ++  AL 
Sbjct: 191 GCNKANKLARSHFAIHRLLLAATHVVFVHPFTNAPLKIHCPPETSFQTALQ 241


>UniRef50_Q2LWV4 Pseudouridine synthase n=1 Tax=Syntrophus aciditrophicus SB
           RepID=Q2LWV4_SYNAS
          Length = 333

 Score =  272 bits (697), Expect = 8e-72,   Method: Composition-based stats.
 Identities = 74/258 (28%), Positives = 126/258 (48%), Gaps = 26/258 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIG----QHVFTAHRLDR 55
           L ILY+D  L+ ++KP+G +VH +       +V  ++   RD  G          HRLD+
Sbjct: 85  LSILYEDHDLLVLDKPAGLVVHPAAGHVSGTLVNALLFHCRDLAGIGGVMRPGIVHRLDK 144

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADK 114
            TSG+L++  +  A + LA QF++HQ+ K Y A+V G   E+   +D P+     +   K
Sbjct: 145 DTSGLLVVAKTDAAHQGLALQFKKHQVGKTYQALVYGDPREKTGQIDLPVGRHPVE-RKK 203

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
            + + +  + A T +R      +             L+ ++  TGR HQ+R HLA + HP
Sbjct: 204 MSTKSRRGKEAATRWRIAERFGV-----------ATLLNVDIVTGRTHQIRVHLAAIGHP 252

Query: 175 IIGDSKHGDLRQNRSGAEHF------GLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWM 228
           ++GD+ +G  ++  +  +         + R  LHA++LS THP T + L  HA L     
Sbjct: 253 VVGDAVYGSSKRATTLTDPAVKGRLKEMSRQALHAARLSFTHPVTHKILEFHAPLPADME 312

Query: 229 QALSQFGWRGLLPENERV 246
              + F  +   P+++ V
Sbjct: 313 DLCA-FLRKHCCPDSQLV 329


>UniRef50_A6DUC9 Pseudouridine synthase n=1 Tax=Lentisphaera araneosa HTCC2155
           RepID=A6DUC9_9BACT
          Length = 323

 Score =  272 bits (697), Expect = 8e-72,   Method: Composition-based stats.
 Identities = 66/244 (27%), Positives = 115/244 (47%), Gaps = 25/244 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQ--------IGQHVFTAHRL 53
           L+I+Y+D+ ++ VNKP+G +VH    +    +V     RD                 HRL
Sbjct: 90  LDIIYEDDDILVVNKPAGMVVHPGAGNYTGTLVNALLGRDLDTFSAMDDGSSRPGIVHRL 149

Query: 54  DRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVE-ELDKI 111
           D+ TSGV+++  S++    L++ F +  ++K Y A+ RG +      +   +     ++ 
Sbjct: 150 DKETSGVIIVAKSAKNLDKLSRSFARRDVEKYYVALCRGTIRVGRDTITSHIGRSRSNRQ 209

Query: 112 ADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHL 171
             +   +    + A++HY+ LA                 LV+L+  TGR HQ+R H++ +
Sbjct: 210 KMENTNDSNRGKEAISHYKVLA-----------DNNGATLVKLKIDTGRTHQIRVHMSGI 258

Query: 172 RHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
            HP++GD  +G  R +    E     R +LHA +  + HP T E +T  A L D +    
Sbjct: 259 NHPVVGDKLYGVRRLD----EKESPDRHILHAWRTRIIHPGTQEIMTFTAPLHDDFKSVC 314

Query: 232 SQFG 235
            +FG
Sbjct: 315 DKFG 318


>UniRef50_Q312A0 Pseudouridine synthase, RluD n=6 Tax=Bacteria RepID=Q312A0_DESDG
          Length = 578

 Score =  271 bits (695), Expect = 1e-71,   Method: Composition-based stats.
 Identities = 71/269 (26%), Positives = 114/269 (42%), Gaps = 25/269 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQT-----VRDQIGQHVFTAHRLDRP 56
           LE+LY+D  ++ +NKP+G  VH +    +  +V         +  Q G      HR+D+ 
Sbjct: 119 LEVLYRDAHMLVINKPAGLTVHPAPSCPEGTLVHRLLHHFPELEAQEGFRPGIVHRIDKD 178

Query: 57  TSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADKF 115
           TSG+LL+ L+ +A   L+  F   +I K Y A+V+G    +   +D P+           
Sbjct: 179 TSGLLLIALTEKARLALSDAFAGRRIHKEYLALVKGIPEGDSGEIDAPVGRHPTHKTRMA 238

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
               +G + A++ +R L              T + LV +   TGR HQ+R H+ H  HP+
Sbjct: 239 VV--RGGREALSTWRVL-----LADPHGGGGTGWTLVAVRIHTGRTHQIRVHMQHTGHPL 291

Query: 176 IGDSKHGDLRQNRSGAEHFGL----QRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
            GD+ +G +           L     R MLHA ++S  HP TG P+         +   +
Sbjct: 292 WGDALYGGMPGREELQTTPALAQTATRQMLHAWKISFDHPVTGAPMQFTLPPPADFGTLI 351

Query: 232 SQFGWRGLLPENERVEFSAPSGQDGEISS 260
              G         R +    +G  G   S
Sbjct: 352 RDLG--------SRCQRVVITGMPGCGKS 372


>UniRef50_Q1ILA4 Pseudouridine synthase n=1 Tax=Candidatus Koribacter versatilis
           Ellin345 RepID=Q1ILA4_ACIBL
          Length = 333

 Score =  271 bits (695), Expect = 1e-71,   Method: Composition-based stats.
 Identities = 71/259 (27%), Positives = 127/259 (49%), Gaps = 30/259 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDE-----KVVVMQTVRDQIGQ------HVFTA 50
           L+++Y+D+ L  +NKP+G +VH      +E      +V     R +              
Sbjct: 82  LDVVYEDDDLAVINKPAGMMVHVGAGATEEERNRGTLVNALLYRFRALSEVGGDMRPGIV 141

Query: 51  HRLDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELD 109
           HRLD+ TSG++++  +  A R LA+QF   ++ K+Y A+V GW  + +  ++ P+  ++ 
Sbjct: 142 HRLDKETSGLIVVAKNDVAHRKLAEQFSSRRVHKKYVALVHGWPKKLKGTINLPIARDMS 201

Query: 110 KIADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLA 169
           +   +      G + A++HY     +E P         ++ LVE++ +TGR HQ+R H+A
Sbjct: 202 R-RTRMTTRGSGGRDALSHYEVKEKIESPY-------GKFALVEVKIETGRTHQIRVHMA 253

Query: 170 HLRHPIIGDSKHGDLRQNRSGAEHFG-------LQRLMLHASQLSLTHPFTGEPLTIHAG 222
            L HP++GD+ +G   + R      G       L+R  LHA+++ L  P TG+ L     
Sbjct: 254 SLGHPVVGDTLYGAPGELRVTKALKGMPSKMASLERNFLHAAEIELQQPATGKALRFVTK 313

Query: 223 LD---DTWMQALSQFGWRG 238
           +    + + + L     RG
Sbjct: 314 VPAALEDFAETLRHPEVRG 332


>UniRef50_Q49WX8 Pseudouridine synthase n=1 Tax=Staphylococcus saprophyticus subsp.
           saprophyticus ATCC 15305 RepID=Q49WX8_STAS1
          Length = 305

 Score =  271 bits (694), Expect = 2e-71,   Method: Composition-based stats.
 Identities = 63/240 (26%), Positives = 110/240 (45%), Gaps = 27/240 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIGQ----HVFTAHRLDR 55
           L+I Y+D+ +  V KP G +VH S       +V  +M  +++  G          HR+D+
Sbjct: 81  LDIYYEDDDVAIVYKPKGMVVHPSAGHYTGTLVNGLMYQMKNLSGINGEIRPGIVHRIDK 140

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADK 114
            TSG+L++  +  A R L  Q     + ++Y A+V G +  +   +D P+    +     
Sbjct: 141 DTSGLLMVAKNDVAHRSLVDQLVNKTVTRKYVALVHGKIPHDYGTVDAPIGRNKNDRQSM 200

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
              +D   + AVTH+  L               +Y L+E + +TGR HQ+R H+ ++ +P
Sbjct: 201 DVVDD--GKEAVTHFNVLEHF-----------NKYTLIECQLETGRTHQIRVHMKYIGYP 247

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           ++GD K+G  +          +    LHA  +   HP T E +     L + + Q LS+ 
Sbjct: 248 LVGDPKYGPKK-------TLDIGGQALHAGIIGFEHPVTHEYIEKSTALPEDFEQLLSEL 300


>UniRef50_C8NEP8 Pseudouridine synthase n=1 Tax=Granulicatella adiacens ATCC 49175
           RepID=C8NEP8_9LACT
          Length = 308

 Score =  271 bits (694), Expect = 2e-71,   Method: Composition-based stats.
 Identities = 70/240 (29%), Positives = 112/240 (46%), Gaps = 28/240 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ--------HVFTAHRL 53
           L+I+++D+ L+ VNKPSG +VH S       +V                        HR+
Sbjct: 80  LDIVFEDDSLIVVNKPSGMVVHPSKGHYSGTLVNALLYHSNSLSDSTSEEIYRPGLVHRI 139

Query: 54  DRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIA 112
           D+ TSG+L++  +++  + LA+Q  ++++ + Y AIV G    E  V+D PL        
Sbjct: 140 DKDTSGLLVIAKNNDVHQKLAEQIAENKMNREYIAIVDGHFAHETGVVDAPLSRHQTNRL 199

Query: 113 DKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLR 172
            +    +KG + A+TH+  L +            + Y LV    +TGR HQ+R H+  ++
Sbjct: 200 KRVV--EKGGKNAITHFEVLDSF-----------SDYSLVSCRLETGRTHQIRAHMEFIK 246

Query: 173 HPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALS 232
           HPI+ D  +    +N   A  FG     LHA  LS THP TGE L         + + + 
Sbjct: 247 HPIVNDPLYHPKGKN---ATEFG---QFLHARTLSFTHPLTGETLNFQVEPPKEFAEFIQ 300


>UniRef50_B5YKV0 Pseudouridine synthase n=1 Tax=Thermodesulfovibrio yellowstonii DSM
           11347 RepID=B5YKV0_THEYD
          Length = 315

 Score =  271 bits (694), Expect = 2e-71,   Method: Composition-based stats.
 Identities = 62/242 (25%), Positives = 113/242 (46%), Gaps = 18/242 (7%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQ------IGQHVFTAHRLDR 55
           ++++Y+D++L+ ++KP+G +V+      D  ++       +              HRLD+
Sbjct: 82  IQVIYKDDYLIVLSKPAGMVVYPCAGHPDGTLMNALAYHVKKLANVGAPFRPGIVHRLDK 141

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKF 115
            TSGV+++ L  E    L + F++ +I+K Y A+V G L     +  P+   +     K 
Sbjct: 142 DTSGVMVVALDDETYYKLVEAFKKREIKKEYLALVYGQLRGSGKITTPVGRAI-YDRKKM 200

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
           + + K  + A+T +  +   +            Y  ++++  TGR HQ+R H + + HP+
Sbjct: 201 SIKSKKAKEAITEWEVIKNFK-----------NYTFLKVKILTGRTHQIRVHFSSIGHPV 249

Query: 176 IGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFG 235
           IGD  +G       G +   + R MLHA ++ L HP T + L   A L D     L+   
Sbjct: 250 IGDKTYGRKTYIEIGNKKIPVSRQMLHAHKIELIHPITEKLLQFEASLPDDIQYILNILE 309

Query: 236 WR 237
            R
Sbjct: 310 DR 311


>UniRef50_A3M2Y1 Pseudouridine synthase n=18 Tax=Gammaproteobacteria
           RepID=A3M2Y1_ACIBT
          Length = 350

 Score =  271 bits (693), Expect = 2e-71,   Method: Composition-based stats.
 Identities = 60/242 (24%), Positives = 107/242 (44%), Gaps = 22/242 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG---QHVFTAHRLDRPTS 58
           L+I+Y+DE ++ +NKP G +VH    +    +V                   HR+D+ TS
Sbjct: 115 LDIVYEDEDILVINKPVGMVVHPGAGNTSSTLVNALLYHSPKSAELSRAGLVHRIDKDTS 174

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           G+L++  + EA   L++Q     + + Y  +  G ++    +D P+              
Sbjct: 175 GLLVVAKNLEAQFSLSKQLGDKSVYRIYDLVTYGNIIAGGTIDEPIKRHPVDRVKMAILP 234

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
             G + AVTHY                   +  V+ + +TGR HQ+R H +++ H ++GD
Sbjct: 235 --GGRDAVTHYNVKERFR-----------DFTRVQAQLETGRTHQIRVHFSYIGHGLVGD 281

Query: 179 SKHGDLRQNRSGAEHF------GLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALS 232
             + +  +  +GA         G +R  LHA++L L HP TGE +   A   + + Q ++
Sbjct: 282 QVYMNRVRIPAGASELLIETLRGFKRQALHAAKLGLKHPRTGEEMLFEAPWPEDFTQLVN 341

Query: 233 QF 234
             
Sbjct: 342 VL 343


>UniRef50_A9BMW0 Pseudouridine synthase n=10 Tax=Comamonadaceae RepID=A9BMW0_DELAS
          Length = 356

 Score =  270 bits (692), Expect = 3e-71,   Method: Composition-based stats.
 Identities = 69/243 (28%), Positives = 108/243 (44%), Gaps = 27/243 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ---HVFTAHRLDRPTS 58
           L+++Y+DE L+ VNKP+G +VH +  +    ++     RD   +        HRLD+ TS
Sbjct: 125 LDVVYEDEHLLVVNKPAGLVVHPAPGNWTGTLLNGLLGRDPKAREVPRAGIVHRLDKDTS 184

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVR---GWLMEEAVLDYPLVEELDKIADKF 115
           G++++  S  A   L        + ++Y A+     G   +   +D P+  +        
Sbjct: 185 GLMVVARSRAAMDALVAMIAARDVSRQYLALAHKAWG-PRKHREVDAPIGRDPRNRLRMA 243

Query: 116 ARE--DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
             +      + A T    LA  E              LV     TGR HQ+R H+A L H
Sbjct: 244 VVDLAQHAGKTARTDIDLLAGNE-----------EVSLVRCTLHTGRTHQIRVHMASLGH 292

Query: 174 PIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           P++ D+ +G       G E  G+ R  LHA +L+ THP TG+ L + A L     QAL  
Sbjct: 293 PLVADAVYG-------GKEAGGMARQALHAFRLAFTHPMTGQALVLRAPLPPDMAQALEN 345

Query: 234 FGW 236
           +G 
Sbjct: 346 WGL 348


>UniRef50_P74346 Uncharacterized RNA pseudouridine synthase slr1629 n=19
           Tax=Bacteria RepID=Y1629_SYNY3
          Length = 327

 Score =  270 bits (691), Expect = 3e-71,   Method: Composition-based stats.
 Identities = 72/244 (29%), Positives = 116/244 (47%), Gaps = 24/244 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIG----QHVFTAHRLDR 55
           L+ILY+DE L+ +NKP+G +VH      D  VV  ++    D  G    Q     HRLD+
Sbjct: 98  LDILYEDEQLIIINKPAGLVVHPGPGHPDGTVVNALLAHCPDLAGIGGVQRPGIVHRLDK 157

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEEL-DKIAD 113
            T+G +++  +  A   L  Q ++   ++ Y  IV G   E +  ++ P+     D+   
Sbjct: 158 DTTGAMVVAKTELALHNLQVQLKEKTARRLYWGIVYGSPKEIQGTVNLPVGRHPGDRQKM 217

Query: 114 KFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
                +KG + AVTH+R L  +             +  +E + +TGR HQ+R H   + H
Sbjct: 218 GIVPVEKGGREAVTHWRLLERI-----------GNHSWLEFQLETGRTHQIRVHSKQMGH 266

Query: 174 PIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           P++GD+ +        G+ +  L    LHA QLSL HP +GE +T  A +   + + L  
Sbjct: 267 PLVGDNLY-----TSPGSVNVNLPGQALHAHQLSLIHPVSGEIITAIAPMPAHFEKLLVY 321

Query: 234 FGWR 237
              R
Sbjct: 322 LRQR 325


>UniRef50_C4FWV7 Pseudouridine synthase n=2 Tax=Firmicutes RepID=C4FWV7_9FIRM
          Length = 309

 Score =  270 bits (691), Expect = 3e-71,   Method: Composition-based stats.
 Identities = 66/241 (27%), Positives = 115/241 (47%), Gaps = 21/241 (8%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIGQ-----HVFTAHRLD 54
           L+I+Y+DE ++ +NKP+G +VH S       +V  ++  +   +            HR+D
Sbjct: 81  LDIIYEDEDILVINKPAGLVVHPSKGHLKGTLVNGLLHYLNGNLSTGSDFYRPGIVHRID 140

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIAD 113
           + TSG+L++   + A + LA Q   H +++ Y A+V G +   +  ++ PL  +      
Sbjct: 141 KDTSGLLVVAKHNAAHQALADQLLNHDMRRSYIALVHGQVKAPQGTIEAPLQRDPANRLR 200

Query: 114 KFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
                 K  + A+T ++ +   E              L++LE +TGR HQ+R HL  + H
Sbjct: 201 WTV--AKEGKYALTRFQVMENFE-----------NATLLDLELETGRTHQIRVHLEFIGH 247

Query: 174 PIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           P++GD  +     +  G+    +   +LHA  L L HP +GE L   A L   + +AL Q
Sbjct: 248 PLVGDPVYRKGLDHIKGSLVHDMTGQLLHAYALKLQHPRSGEWLEFKAPLPRRFEEALDQ 307

Query: 234 F 234
            
Sbjct: 308 L 308


>UniRef50_A6C0W7 Pseudouridine synthase n=1 Tax=Planctomyces maris DSM 8797
           RepID=A6C0W7_9PLAN
          Length = 342

 Score =  270 bits (691), Expect = 4e-71,   Method: Composition-based stats.
 Identities = 65/256 (25%), Positives = 112/256 (43%), Gaps = 32/256 (12%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV-VMQTVRDQIGQ-----HVFTAHRLDR 55
           ++I+Y+D+W+  +NKPS  +VH    +    +   +Q   DQ+            HRLDR
Sbjct: 93  IDIVYEDDWIAIINKPSDMIVHPGKGNYAGTLAGALQYHFDQLSDVAGQYRPGIVHRLDR 152

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADK 114
            TSG++++   ++    L+ QFE+  +QK Y AIV G +  +   +D  +          
Sbjct: 153 NTSGIMVVAKDNQVHAKLSAQFEKRDVQKEYRAIVWGRMEFDTDYIDTFMCVHPRAREKM 212

Query: 115 FAREDKG-PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
              ++ G  + A T+Y  +   +            +  V L+P+TGR HQLR H+ H+ H
Sbjct: 213 IVCDEGGNARNAFTYYEVIERYQA-----------FTYVRLKPRTGRTHQLRVHMQHIGH 261

Query: 174 PIIGDSKHGDLRQNR-------------SGAEHFGLQRLMLHASQLSLTHPFTGEPLTIH 220
            I+ D  +G  +  +                    ++R  LHA  L   HP +G+P+   
Sbjct: 262 SIVADRVYGGHKSLKMKSLGIQAEADAAELESDVLIERQALHAYCLEFFHPQSGKPMKFE 321

Query: 221 AGLDDTWMQALSQFGW 236
           A L +     L+    
Sbjct: 322 APLPEDMQNTLAALDQ 337


>UniRef50_A5WFS2 Pseudouridine synthase n=3 Tax=Psychrobacter RepID=A5WFS2_PSYWF
          Length = 420

 Score =  269 bits (690), Expect = 4e-71,   Method: Composition-based stats.
 Identities = 65/241 (26%), Positives = 114/241 (47%), Gaps = 24/241 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIG-QHVFTAHRLDRPTS 58
           L+I+Y+D+ ++ +NKP G +VH    +    +V  ++    +Q         HR+D+ TS
Sbjct: 181 LDIIYEDDSVIVINKPVGMVVHPGAGNWSGTLVNGLLYHYPNQAHLPRAGLVHRIDKNTS 240

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGW---LMEEAVLDYPLVEELDKIADKF 115
           G+L++G +  A   L +Q +   + + Y  +V G    L  +  +D P+     +     
Sbjct: 241 GLLVIGKTKAAQLELQEQLKDKSVYRHYQCVVAGDAPSLARQRTIDAPIGRHRTQRTKMT 300

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
                  + A+TH   +  +          +  Y L+++  +TGR HQ+R HL+H+ HPI
Sbjct: 301 VTS--TGKTAITHIMKITPL----------SDTYSLLDVRLETGRTHQIRVHLSHIGHPI 348

Query: 176 IGDSKHGDLRQNRSGAEHF------GLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQ 229
           IGD  +G+ +Q R+G             R  LHA +L   HP TGE + + A L    ++
Sbjct: 349 IGDDIYGNRQQLRAGLTPEQRQAIQSFPRQALHAYKLGFIHPETGESIELTAPLPQDIVE 408

Query: 230 A 230
            
Sbjct: 409 L 409


>UniRef50_D1RB31 Pseudouridine synthase n=1 Tax=Parachlamydia acanthamoebae str.
           Hall's coccus RepID=D1RB31_9CHLA
          Length = 319

 Score =  269 bits (690), Expect = 5e-71,   Method: Composition-based stats.
 Identities = 70/240 (29%), Positives = 101/240 (42%), Gaps = 26/240 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG--------QHVFTAHRL 53
           L ILY+DE L+ +NKP G +VH +  +     V                        HRL
Sbjct: 87  LNILYEDEHLLIINKPVGMVVHPAPGNWTGTFVNALLYHCGYSLSDASVDSIRPGIVHRL 146

Query: 54  DRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIAD 113
           D+ TSGVL+   +    + L + F   Q+ K Y AI  G       L++P+         
Sbjct: 147 DKETSGVLVAAKTLSVQQKLMELFAARQVYKEYWAICLGNP-GNCELNWPIGRHPIHRKQ 205

Query: 114 KFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
              RED   + A+T    L                  L +L   TGR HQ+R HL H  H
Sbjct: 206 MTVRED--GKEALTFCETLEV-----------GNEICLAKLILSTGRTHQIRVHLKHKGH 252

Query: 174 PIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           PI+GDS +G  + N      +  +R MLHA +L+  HP T + + + A L     + L +
Sbjct: 253 PILGDSIYGSKQVN----MRYRAERQMLHARKLAFIHPITQQKIEVEAPLPADMEECLRK 308


>UniRef50_Q3A0C2 Pseudouridine synthase n=13 Tax=Bacteria RepID=Q3A0C2_PELCD
          Length = 326

 Score =  269 bits (689), Expect = 6e-71,   Method: Composition-based stats.
 Identities = 73/246 (29%), Positives = 116/246 (47%), Gaps = 23/246 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIGQ----HVFTAHRLDR 55
           L ILY+D  L+ ++KP G +VH +       +V  ++   +D  G          HRLD+
Sbjct: 81  LVILYEDRHLIVIDKPPGMVVHPAPGHYQGTLVNALLHHCQDLSGIGGELRPGIVHRLDK 140

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADK 114
            TSGV++   +  A + LA QF+ H I +RY A++ G L  +   +D P+         K
Sbjct: 141 DTSGVMVATKTDSAHQSLAAQFKAHSITRRYIALIHGVLTGDRGSIDRPIGRHPTH-RKK 199

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
            +   +  + AVTH+R L          R+   R  LVEL  +TGR HQ+R H +  +HP
Sbjct: 200 MSTTCRTGRHAVTHWRVLR---------RFDDDRLTLVELALETGRTHQIRVHFSEQQHP 250

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQ------RLMLHASQLSLTHPFTGEPLTIHAGLDDTWM 228
           ++GD  +G   + ++  +   L+      R  LHA  L   HP TG+ L   + L +   
Sbjct: 251 LLGDPVYGGSGRLKTINDPQLLKRAKALGRQALHARLLGFQHPETGKYLEFSSPLPEDLR 310

Query: 229 QALSQF 234
             +   
Sbjct: 311 SVIDYL 316


>UniRef50_C8PVB8 Pseudouridine synthase n=2 Tax=Moraxellaceae RepID=C8PVB8_9GAMM
          Length = 380

 Score =  269 bits (689), Expect = 6e-71,   Method: Composition-based stats.
 Identities = 68/248 (27%), Positives = 108/248 (43%), Gaps = 27/248 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVR---DQIGQHVFTAHRLDRPTS 58
           L+ILY+DE ++ +NKP G +VH    +    +V          +        HR+D+ TS
Sbjct: 143 LDILYEDEAVLVINKPVGLVVHPGAGNGSGTLVNALLFHYPDSRTLPRAGLVHRIDKETS 202

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIV---RGWLMEEAVLDYPLVEELDKIADKF 115
           G++++   S++   L  Q +   + + Y AIV      L     +D P+     +     
Sbjct: 203 GLMVIAKDSQSQLHLINQLKDKSVYRLYQAIVLASAAELARHRTIDAPIGRHPTQRTKMA 262

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
                  +PAVTH   +  +   V           LV +  +TGR HQ+R HL++L  P+
Sbjct: 263 VVSS--GKPAVTHLEKITAISDAV----------SLVSVRLETGRTHQIRVHLSNLGFPL 310

Query: 176 IGDSKHGDLRQNRSGAEHFG---------LQRLMLHASQLSLTHPFTGEPLTIHAGLDDT 226
           +GD  +G  R+N    +             QR  LHA +L   HP TGEP+ + A L + 
Sbjct: 311 LGDPLYGAARKNAILLKTLDDDQKHIVQQFQRQALHAYELGFIHPKTGEPIKVQARLPED 370

Query: 227 WMQALSQF 234
             Q L   
Sbjct: 371 MQQLLDTL 378


>UniRef50_D2BIX0 Pseudouridine synthase n=5 Tax=Dehalococcoides RepID=D2BIX0_DEHSV
          Length = 302

 Score =  269 bits (689), Expect = 6e-71,   Method: Composition-based stats.
 Identities = 66/241 (27%), Positives = 111/241 (46%), Gaps = 28/241 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVV-MQTVRDQIGQ-----HVFTAHRLDR 55
           LEI++QD+ L+ +NKP G  VH +    D  ++  +  +  ++            HRLD+
Sbjct: 80  LEIIFQDKDLLLINKPPGLTVHPAPGHPDHTLINGVLALEPKMEDFDDPLRPGIVHRLDK 139

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADK 114
            TSG+LL+  + E    L+ QF++  ++K Y  +V+G L   E  ++ PL  +       
Sbjct: 140 DTSGLLLVAKNRETLANLSAQFKERTVRKYYLTLVKGELHPAEGFIEAPLGRDPQNRQKI 199

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
                   + A T Y+ L  +             Y L+E++ +TGR HQ+R H A + HP
Sbjct: 200 AVVS--NGRHARTGYKVLRYI-----------QGYSLLEVKLETGRTHQIRVHFAAIGHP 246

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           + GD+ +G         +   L+R  LHA +LS T P  G+ +   + L     + L   
Sbjct: 247 VAGDAIYG--------QKETWLKRQFLHAHRLSFTLPSNGQTVEFTSPLPPDLEETLKIL 298

Query: 235 G 235
            
Sbjct: 299 E 299


>UniRef50_Q2W2D5 Pseudouridine synthase n=39 Tax=Bacteria RepID=Q2W2D5_MAGSA
          Length = 505

 Score =  269 bits (689), Expect = 6e-71,   Method: Composition-based stats.
 Identities = 65/249 (26%), Positives = 108/249 (43%), Gaps = 25/249 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG-------QHVFTAHRLD 54
           L ++Y+DE L+ ++KP+G +VH +  + DE +V                 +     HR+D
Sbjct: 265 LTVVYEDEDLIVIDKPAGMVVHPAPGNPDETLVNALLAHCGESLAGIGGVKRPGIVHRID 324

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIAD 113
           + TSG+L+   +  A R LA QF  H +++ Y A+V G     +  ++  +    +    
Sbjct: 325 KDTSGLLVAAKTDAAHRGLATQFAAHTLERAYWALVWGTPSPRQGEIEGNIGRNPND-RK 383

Query: 114 KFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
           K A    G +PA+T YR L +         +      LVE    TGR HQ+R H+    H
Sbjct: 384 KMAVVKSGGKPALTRYRVLKS---------FAGGAVSLVECRLATGRTHQIRVHMTTQGH 434

Query: 174 PIIGDSKHGDLRQNRS-------GAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDT 226
           P++GD  +G +R ++                R  LHA  L  +HP  G  +   +G+   
Sbjct: 435 PLVGDPVYGRIRGHKGVVLPPEVKTALIQFPRQALHAYLLGFSHPTKGYDVRFESGMPLD 494

Query: 227 WMQALSQFG 235
               +    
Sbjct: 495 INALMQILE 503


>UniRef50_D1VS73 Pseudouridine synthase n=1 Tax=Peptoniphilus lacrimalis 315-B
           RepID=D1VS73_9FIRM
          Length = 295

 Score =  269 bits (689), Expect = 7e-71,   Method: Composition-based stats.
 Identities = 58/239 (24%), Positives = 110/239 (46%), Gaps = 25/239 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIGQ----HVFTAHRLDR 55
             ++Y+DE++  ++KP   +VH    +    +V  ++   ++Q+           HRLD+
Sbjct: 75  FNVIYEDEYIAVISKPQDLVVHIGAGNSSGTLVNGLLYKFKNQLSDLDPLRPGIVHRLDK 134

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKF 115
            TSG++++  +++A   L  QF+  QI+K Y AIV G   E  ++  P+    +    K 
Sbjct: 135 NTSGLMIIAKNNQAHINLVDQFKNSQIKKYYLAIVHGKTPESGIIAEPIGRNPND-RKKM 193

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
           A   K  + A+T Y+ L                Y L+ +   TGR HQ+R H+A++ +P+
Sbjct: 194 AVVYKNSKQAITKYKKLKEF-----------QEYSLLNINLLTGRTHQIRVHMAYIGYPV 242

Query: 176 IGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           +GD  +G             + + MLH+ +L   HP T + +         + + + + 
Sbjct: 243 LGDIIYGRK-------NSLKIDKQMLHSYKLIFNHPITNQKMEFTDEFPIRFKKFIDKI 294


>UniRef50_C6VVP1 Pseudouridine synthase n=4 Tax=Bacteroidetes RepID=C6VVP1_DYAFD
          Length = 228

 Score =  269 bits (688), Expect = 8e-71,   Method: Composition-based stats.
 Identities = 106/236 (44%), Positives = 143/236 (60%), Gaps = 11/236 (4%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           LEILY+ + LVA+NKP+G LVHRS +  D  V  +Q +RDQ+ Q V+ AHRLDR TSGVL
Sbjct: 4   LEILYRSDDLVAINKPNGLLVHRSPIASDADVFAVQLLRDQLSQKVYPAHRLDRKTSGVL 63

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKG 121
           L  L+      +  +F + +I K YHAIVRG   +   +DYPL  +           D  
Sbjct: 64  LFALNENVNSEMQGKFMEGEITKTYHAIVRGHTADRGEIDYPLKRD-----------DGV 112

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
            Q AVTH+  LA  E+P A G++ T+RY LV+L P TGR HQLR+H+AH+ HPIIGD  H
Sbjct: 113 TQDAVTHFETLARAEVPFALGKHATSRYSLVQLNPLTGRMHQLRKHMAHIMHPIIGDRPH 172

Query: 182 GDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWR 237
           G  +QNR   E  G+ ++MLHA  +   HP +G+ +TI A     +++  S  G  
Sbjct: 173 GCNKQNRFFKEELGMIQMMLHAVSVEFVHPVSGQHVTIVAPYLSEFVRMRSVLGLE 228


>UniRef50_B8E0R4 Pseudouridine synthase n=1 Tax=Dictyoglomus turgidum DSM 6724
           RepID=B8E0R4_DICTD
          Length = 303

 Score =  268 bits (687), Expect = 1e-70,   Method: Composition-based stats.
 Identities = 62/240 (25%), Positives = 120/240 (50%), Gaps = 26/240 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIGQ----HVFTAHRLDR 55
           +EI+Y+DE +V +NKP G +VH +    ++ +V  ++  V+D  G          HRLD+
Sbjct: 79  IEIVYEDEDMVIINKPKGMVVHPAHGHYNDTLVNALLYRVKDLSGIGGELRPGIIHRLDK 138

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADK 114
            T+G+L++  +  + + L++Q +   +++ Y A+  G +  EE  ++ P+          
Sbjct: 139 DTTGLLIIAKNDLSHQKLSEQLKNRTLRRTYWALCEGEIPWEEKRIEAPIGRHPINRKKM 198

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
                   + A+T+++ L   +            Y L+  + +TGR HQ+R H++HL  P
Sbjct: 199 AIVPY--GKIAITNFKVLERFK-----------GYTLISADLETGRTHQIRVHISHLGFP 245

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           I+GD  +G +       + FG++  +LHA ++S  HP  G P+     L + + + L+  
Sbjct: 246 IVGDEVYGRID------KKFGVKGQLLHAKKVSFIHPTKGIPMEFEIDLPEEFKKVLTLL 299


>UniRef50_Q3AVX8 Pseudouridine synthase n=40 Tax=cellular organisms
           RepID=Q3AVX8_SYNS9
          Length = 339

 Score =  268 bits (685), Expect = 2e-70,   Method: Composition-based stats.
 Identities = 65/244 (26%), Positives = 104/244 (42%), Gaps = 23/244 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIGQ----HVFTAHRLDR 55
           L++L++DE ++ +NK +G  VH +  ++D  +V  ++    D  G          HRLD+
Sbjct: 106 LDVLFEDEHIIVLNKSAGLTVHPAPGNKDGTLVNGLLHHCPDLPGISGKLRPGIVHRLDK 165

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADK 114
            TSG +++  S EA   L  Q ++    + Y A+V G    +   +   +          
Sbjct: 166 DTSGCIVVAKSQEALVKLQVQIQKRVASREYFAVVHGVPDGDSGTIIGAVGRHPVDRKKY 225

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
               D+  + A TH+  +                Y L+  +  TGR HQ+R H AH+ HP
Sbjct: 226 AVVSDESGRYARTHWTLIERF-----------GDYSLLRFKLDTGRTHQIRVHCAHINHP 274

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           ++GD  +   R+         L    LHA QL L HP TGE +   A L     + L   
Sbjct: 275 VVGDPTYSRCRKLP-----LDLPGQALHAVQLGLDHPITGERMVFEAPLPPVMEKLLLVL 329

Query: 235 GWRG 238
             R 
Sbjct: 330 RRRS 333


>UniRef50_C4XSN0 Ribosomal large subunit pseudouridine synthase D/dephospho-CoA
           kinase n=1 Tax=Desulfovibrio magneticus RS-1
           RepID=C4XSN0_DESMR
          Length = 554

 Score =  268 bits (685), Expect = 2e-70,   Method: Composition-based stats.
 Identities = 80/269 (29%), Positives = 124/269 (46%), Gaps = 28/269 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQT-----VRDQIGQHVFTAHRLDRP 56
           L++LY D  ++ +NKP+G  +H +    D  +V         +R   G      HRLD+ 
Sbjct: 93  LKLLYLDGDVLVLNKPAGLTIHPASSQPDGTLVNRLLHHFPDMRAMAGDRPGIVHRLDKD 152

Query: 57  TSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADKF 115
           TSG+LL+  +  A   LA  F + ++ K Y A+V G     + V++ P+  +  K   K 
Sbjct: 153 TSGLLLVAQTESARLALAADFAERRVAKTYLALVHGRPERSDGVIELPVGRDP-KHPTKM 211

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
           A   KG + A + ++   T          P     L+E+   TGR HQ+R H+A + HPI
Sbjct: 212 AVVAKGGREAKSSWKLAWTA---------PDGTASLLEVAIATGRTHQIRVHMAAMGHPI 262

Query: 176 IGDSKHGDLRQN----RSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
           +GD+ +G  + +    R GA     +R MLHA +L+ +HP TGE L+        +    
Sbjct: 263 VGDAVYGARQHSDWTRRGGAMARLAKRQMLHAWKLAFSHPGTGEELSFCQPPPADF---- 318

Query: 232 SQFGWRGLLPENERVEFSAPSGQDGEISS 260
               WR LL    R +     G  G   S
Sbjct: 319 ----WRLLLMLGRRCQRVGLVGMPGCGKS 343


>UniRef50_C6BSG2 Pseudouridine synthase, RluA family n=1 Tax=Desulfovibrio
           salexigens DSM 2638 RepID=C6BSG2_DESAD
          Length = 549

 Score =  267 bits (684), Expect = 3e-70,   Method: Composition-based stats.
 Identities = 73/269 (27%), Positives = 114/269 (42%), Gaps = 28/269 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQT-----VRDQIGQHVFTAHRLDRP 56
           LEI+Y D  +  +NKP+G   H +       +V         +RD         HRLD+ 
Sbjct: 94  LEIIYNDGKIAVINKPAGLTTHPAPSCPTGTLVHRMIHHFPEIRDMDEWRPGIVHRLDKF 153

Query: 57  TSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADKF 115
           TSG++ + L+      ++  F   ++ K Y AIV G    E   +D P+         K 
Sbjct: 154 TSGLITVALNEHDRLAMSTAFADREVNKAYLAIVHGVPKREFGEIDQPMGRHPVH-KTKM 212

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
           A   KG + A + Y  L +          P  R  LV+++  TGR HQ+R H+AH+ HP+
Sbjct: 213 AVVLKGGRDARSEYEVLWSD---------PAGRASLVKVKIYTGRTHQIRVHMAHIGHPL 263

Query: 176 IGDSKHGDLRQNRSGAEHFGL----QRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
           +GD  +G +       +   L    +R MLHA  LS THP + E L+      + ++  L
Sbjct: 264 VGDQVYGSMPHAIWEQDQPQLAKLAERQMLHAYSLSFTHPDSEEELSFTQAPPEDFINML 323

Query: 232 SQFGWRGLLPENERVEFSAPSGQDGEISS 260
                      ++ V+     G      S
Sbjct: 324 KAL--------DKSVQRVGLIGMPCGGKS 344


>UniRef50_Q87AR7 Ribosomal large subunit pseudouridine synthase D n=18
           Tax=Gammaproteobacteria RepID=RLUD_XYLFT
          Length = 331

 Score =  267 bits (683), Expect = 3e-70,   Method: Composition-based stats.
 Identities = 72/248 (29%), Positives = 109/248 (43%), Gaps = 22/248 (8%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG---QHVFTAHRLDRPTS 58
           L+ILY+DE +  +NKP+G +VH    + D  +V     RD            HRLD+ TS
Sbjct: 90  LDILYEDEHVFVINKPAGLVVHPGAGNPDGTLVNALLHRDPALAAVPRAGVVHRLDKDTS 149

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           GV+++  + +A   L +Q    Q+ ++Y A+V   L+    ++  +             +
Sbjct: 150 GVMVVARTLQAQTALVEQLSSRQVHRQYLAVVVSALVSGGTVNAAIERHPRDRLRMEVSD 209

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
               + AVTHYR                  +  +E    TGR HQ+R H+AHLRHPI+GD
Sbjct: 210 --TGKEAVTHYRLRERFRA-----------HTALECRLDTGRTHQIRVHMAHLRHPIVGD 256

Query: 179 SKHGDLRQNRSG------AEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALS 232
             +G   +   G      A   G +R  LHA  L   HP    P+ I A + +   Q L+
Sbjct: 257 RLYGGSLKLPKGGTDALVAMLRGFKRQALHAEVLEFLHPVRALPVRIVAPVPEDLCQLLA 316

Query: 233 QFGWRGLL 240
                  L
Sbjct: 317 ALREDSAL 324


>UniRef50_C9LM35 Pseudouridine synthase n=1 Tax=Dialister invisus DSM 15470
           RepID=C9LM35_9FIRM
          Length = 308

 Score =  267 bits (683), Expect = 3e-70,   Method: Composition-based stats.
 Identities = 66/239 (27%), Positives = 113/239 (47%), Gaps = 26/239 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQI-------GQHVFTAHRLD 54
           L+ILY+D  ++ +NK  G +VH    + +  +V                 +     HRLD
Sbjct: 80  LDILYEDNDMIVINKRRGVVVHPGAGNTEGTLVNALLFHCGEQLRSVGDPERPGIVHRLD 139

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIAD 113
           + TSGV++   S  A  +L ++   H+ Q+ Y A+V G +  +  V+  PL     K   
Sbjct: 140 KDTSGVMVAAKSERAYGILQKEIASHKAQRCYIALVHGQMEGDTGVIRLPLGR-STKDRM 198

Query: 114 KFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
           K+    +  +PAVTH+  +  +             Y  +E + +TGR HQ+R H+AH+RH
Sbjct: 199 KWDVLHETGRPAVTHFHVIEYL-----------PHYSWIECKLETGRTHQIRVHMAHIRH 247

Query: 174 PIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALS 232
            ++ D  +G  +      +HF ++   LH+  L L HP TGE +   A + +  +  L+
Sbjct: 248 AVVNDPLYGWKK------DHFPIKGQALHSHTLELCHPITGEVMHFEAPVPEDMINCLN 300


>UniRef50_A5EX53 Pseudouridine synthase n=1 Tax=Dichelobacter nodosus VCS1703A
           RepID=A5EX53_DICNV
          Length = 322

 Score =  267 bits (683), Expect = 4e-70,   Method: Composition-based stats.
 Identities = 69/247 (27%), Positives = 110/247 (44%), Gaps = 22/247 (8%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHV---FTAHRLDRPTS 58
           L ILY D+ ++ +NKP+G +VH +  + D  ++          +H+      HRLD+ TS
Sbjct: 86  LNILYADDDIIVINKPAGLVVHPAVGNHDNTLLNALLYHFPQTKHLPRSGIVHRLDKDTS 145

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           G +++  S+ A   L +Q +   + + Y A+V G++     +D P+            R 
Sbjct: 146 GAMVIAHSARAHTDLVRQLQNRSMGRIYLALVYGYITAGDTIDLPIGRHAKDRLKMAVRP 205

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
           D   +PA+THYR                    L+ ++ +TGR HQ+R HL+H RHP++GD
Sbjct: 206 D--GKPAITHYRIEERW-----------QTLTLLRVQLETGRTHQIRVHLSHHRHPLVGD 252

Query: 179 SKHGDLRQNRSGAEHF------GLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALS 232
             +G      S              R  LHA +L L HP T E +   A L D   Q  +
Sbjct: 253 KLYGARPFLASSLTELQRQALAEFPRQALHAVELHLHHPATNEIMRFTAPLPDDMTQLFT 312

Query: 233 QFGWRGL 239
               +  
Sbjct: 313 ILRAQNP 319


>UniRef50_C6WV38 Pseudouridine synthase n=3 Tax=Proteobacteria RepID=C6WV38_METML
          Length = 368

 Score =  266 bits (682), Expect = 4e-70,   Method: Composition-based stats.
 Identities = 65/243 (26%), Positives = 107/243 (44%), Gaps = 23/243 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRD---QIGQHVFTAHRLDRPTS 58
           L+I+Y+D+ ++ VNKP+G +VH +  + D  ++                   HRLD+ TS
Sbjct: 90  LDIVYEDDHILVVNKPAGMVVHPAAGNWDGTLLNALLFHAPQLHDVPRAGIVHRLDKETS 149

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           G+L++  +  A   L +Q +   +++ Y AIV G L    V+D PL  +           
Sbjct: 150 GLLVVAKTLNAQTHLVRQLQARTVKREYRAIVWGQLWRNGVVDQPLGRDPRSRTKMAI-- 207

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
           ++  +PA+T Y  L    +              +    +TGR HQ+R H+ HL+ P++GD
Sbjct: 208 NRMGKPAITRYEILERFSVQ-----------TYLRCNLETGRTHQIRVHMQHLKAPLVGD 256

Query: 179 SKHG--DLRQNRSGAEHF-----GLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
             +G   +   R+  +          R  LHA +L L HP T E +     L D     L
Sbjct: 257 PVYGFRGIVPIRAMTQTLRDAVSQFHRQALHAIKLGLVHPATNEFMEWQIELADDMKVLL 316

Query: 232 SQF 234
              
Sbjct: 317 EAM 319


>UniRef50_A0L9J0 Pseudouridine synthase n=1 Tax=Magnetococcus sp. MC-1
           RepID=A0L9J0_MAGSM
          Length = 332

 Score =  266 bits (682), Expect = 4e-70,   Method: Composition-based stats.
 Identities = 67/253 (26%), Positives = 106/253 (41%), Gaps = 32/253 (12%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ-------------HVF 48
           LEIL++DE L+ +NKP+G +VH         +V                           
Sbjct: 87  LEILFEDEHLIVLNKPAGMVVHPGAGVNHGTLVNALLYHCGTPDNPHGGLSGIGGVIRPG 146

Query: 49  TAHRLDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEE 107
             HRLD+ TSG+++      A   L++QFEQ  I +RY A+ RG     +  ++  +   
Sbjct: 147 IVHRLDKETSGIMVAAKQDHAHIHLSRQFEQRTIGRRYLALTRGIPQPAQGRIEGAIGRH 206

Query: 108 LDKIADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRH 167
                 K A  ++G + A T Y+ L            P  ++ L+    ++GR HQ+R H
Sbjct: 207 PIH-RTKMAVVEQGGRAAATRYKVLE-----------PLGQFALIRCRLESGRTHQIRVH 254

Query: 168 LAHLRHPIIGDSKHGDLRQNRSGAEHFG------LQRLMLHASQLSLTHPFTGEPLTIHA 221
           + H+ HP++GD  +G   +  S             QR  LHA  L+  HP TGE ++   
Sbjct: 255 MTHIGHPLVGDPLYGAQHKAPSHWPPLHRQRFDQFQRQALHAHTLTFIHPHTGEEMSFKR 314

Query: 222 GLDDTWMQALSQF 234
                + Q     
Sbjct: 315 PPPADFRQLYETL 327


>UniRef50_A8GQ59 Pseudouridine synthase n=15 Tax=Rickettsia RepID=A8GQ59_RICAH
          Length = 329

 Score =  266 bits (682), Expect = 4e-70,   Method: Composition-based stats.
 Identities = 63/244 (25%), Positives = 111/244 (45%), Gaps = 21/244 (8%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQ------IGQHVFTAHRLDR 55
           L+I+Y+D+ L+ +NK +G  VH      D+ +V       +              HRLD+
Sbjct: 79  LDIIYEDDDLIVINKAAGMTVHPGAGHHDDTLVNALLYHTKNLSDIGSAARPGIVHRLDK 138

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKF 115
            T+G++++  +++A  LLA Q EQ Q+ ++Y A+V G +   A +    +        K 
Sbjct: 139 DTTGLMVVAKNNKAHMLLANQIEQRQVIRKYKALVWGVINPLAGVIKNNIGRSRVERQKM 198

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
           +    G + AVTHY+ L                  +VE    TGR HQ+R  L+H++H +
Sbjct: 199 SILKYGGKEAVTHYKTLELFY---------GGTISMVECRLNTGRTHQIRVQLSHVKHSV 249

Query: 176 IGDSKHGDLRQNRS------GAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQ 229
           +GD  +G+  +  +       A+    +R  LH+  LS THP + + +     L      
Sbjct: 250 VGDQTYGNNDRKIAHSSPALKAKLIDFKRQALHSWYLSFTHPTSNKIMEFSCELPRDMEA 309

Query: 230 ALSQ 233
            ++ 
Sbjct: 310 IIAT 313


>UniRef50_C0BNA6 Pseudouridine synthase n=7 Tax=Bacteroidetes RepID=C0BNA6_9BACT
          Length = 379

 Score =  266 bits (681), Expect = 5e-70,   Method: Composition-based stats.
 Identities = 61/254 (24%), Positives = 107/254 (42%), Gaps = 30/254 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQ-----IGQHVFTAHRLDRP 56
           L+++Y+D  L+ VNKP G +VH    +    ++       +       +     HR+D+ 
Sbjct: 132 LDVVYEDSDLMVVNKPPGMVVHPGHGNYSGTLINALLFHVKDLPLNADERPGLVHRIDKD 191

Query: 57  TSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADKF 115
           TSG+L++  +++A   LA+QF     ++ Y AIV G + EE   +   +           
Sbjct: 192 TSGLLVVAKTAKAMTHLAKQFFDKTSEREYVAIVWGNVEEEQGTVRGHIGRHPKNRLQMA 251

Query: 116 AREDKG-PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
              D    + AVTHY+ +  +               LV    +TGR HQ+R H+ H+ H 
Sbjct: 252 VFPDGDQGKEAVTHYKVMERLGYV-----------TLVSCVLETGRTHQIRAHMKHIGHT 300

Query: 175 IIGDSKHGDLRQNRSGA----------EHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLD 224
           +  D ++G  +  +                 L R  LHA  L   HP +GE +  +  + 
Sbjct: 301 LFNDERYGGEKILKGTTFTKYKQFVDNAFKALPRQALHAKTLGFVHPSSGELMRFNTPIP 360

Query: 225 DTWMQALSQFGWRG 238
           +  +  + +  WR 
Sbjct: 361 EDMVLCIEK--WRA 372


>UniRef50_Q0BWH2 Pseudouridine synthase n=3 Tax=Alphaproteobacteria
           RepID=Q0BWH2_HYPNA
          Length = 341

 Score =  266 bits (681), Expect = 6e-70,   Method: Composition-based stats.
 Identities = 73/257 (28%), Positives = 116/257 (45%), Gaps = 26/257 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIG-----QHVFTAHRLD 54
           LEIL++D  LV +NK +G  VH +   +   +V  ++   + Q+      +     HRLD
Sbjct: 81  LEILFEDAHLVILNKAAGMAVHPAPGSQTGTLVNALLHHCQGQLSGIGGVERPGIVHRLD 140

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVE---ELDK 110
           + TSGV++   +  A   LA  FE+H I + Y A+ RG        ++  +     +  K
Sbjct: 141 KLTSGVMVAAKTESAHTGLAALFERHDIDRVYRAVTRGAPRPLSGTIEAAIARSESDRKK 200

Query: 111 IADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAH 170
           ++     +    + AVTHY+ + T        R P     L+E   +TGR HQ+R H+AH
Sbjct: 201 MSVHRNPDSPAARHAVTHYKAVETFGYKDRATRLPA--AALLECRLETGRTHQIRVHMAH 258

Query: 171 LRHPIIGDSKHG-------------DLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPL 217
              P+IGD  +G             + R +++ A      R  LHA+ L   HP TGE L
Sbjct: 259 SGAPLIGDPVYGRQAGIMAWKAPGSEARYDKALAAARAFSRQALHAAVLGFVHPITGETL 318

Query: 218 TIHAGLDDTWMQALSQF 234
              A L +     ++  
Sbjct: 319 RYEAPLPEDMTGLIAAL 335


>UniRef50_B8J173 Pseudouridine synthase, RluA family n=2 Tax=Desulfovibrio
           RepID=B8J173_DESDA
          Length = 525

 Score =  266 bits (680), Expect = 7e-70,   Method: Composition-based stats.
 Identities = 78/265 (29%), Positives = 112/265 (42%), Gaps = 29/265 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQI-----GQHVFTAHRLDRP 56
           LE+L+QD+ LV  NKP+G  VH      ++ +V     R        GQ     HRLD+ 
Sbjct: 80  LELLWQDDHLVVCNKPAGLTVHPCPSCPEQTLVQRLLGRFPQLSRLEGQRPGIVHRLDKD 139

Query: 57  TSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELD-KIADKF 115
           TSG+L++ L+      LA  F + Q+ K Y A+V G    E     PL      KI    
Sbjct: 140 TSGLLVVALTEADCLALAAAFAERQVHKEYLALVSGLPPLEGQCREPLGRHPTAKIKMAV 199

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
             ED+G + A T +R L   +              L+ +   TGR HQ+R H+ HL +P+
Sbjct: 200 VPEDQGGRNAFTEWRRLWNTD---------DGSVSLLAVRIHTGRTHQIRVHMTHLGYPL 250

Query: 176 IGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFG 235
           +GD  +         A      R MLHA +L  THP +GE +            A     
Sbjct: 251 LGDRLY------APKAVQNMAPRQMLHAWRLGFTHPASGEDMRFTCPPPHDMPDA----- 299

Query: 236 WRGLLPENERVEFSAPSGQDGEISS 260
               L   +R++    +G  G   S
Sbjct: 300 ---ALAAMQRMQRLVITGNPGSGKS 321


>UniRef50_C5VRN0 Pseudouridine synthase n=1 Tax=Clostridium botulinum D str. 1873
           RepID=C5VRN0_CLOBO
          Length = 302

 Score =  266 bits (680), Expect = 7e-70,   Method: Composition-based stats.
 Identities = 65/237 (27%), Positives = 115/237 (48%), Gaps = 24/237 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIGQH-VFTAHRLDRPTS 58
           L+I+Y+D  ++ VNKP G +VH +    +  +   V+    D+     V   +RLD  TS
Sbjct: 83  LDIIYEDNDIIVVNKPKGIVVHPTKRHLNGTLSNGVLYYFNDKNENSIVRLVNRLDMDTS 142

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADKFAR 117
           G++L+  ++ +   L++  ++    K+Y AIV G   E+  V+D P+    +    +   
Sbjct: 143 GLVLIAKNAYSHMALSRDMQKDDFVKKYLAIVHGNFNEDSGVIDKPIYRVGEGTLKRII- 201

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
            D+  Q ++T ++ +   +              LVEL  +TGR HQ+R HL+ + HPI G
Sbjct: 202 -DERGQRSITLFKVIEQYK-----------NASLVELTLETGRTHQIRVHLSSIGHPIYG 249

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           DS +G+        E   + R  LHA +L + HP  G+ L + + L +     + + 
Sbjct: 250 DSLYGE-------EEPQYIDRQALHAYKLQIPHPKDGKILKLESSLPEDMKNLIRKL 299


>UniRef50_C0ZH07 Pseudouridine synthase n=1 Tax=Brevibacillus brevis NBRC 100599
           RepID=C0ZH07_BREBN
          Length = 306

 Score =  265 bits (679), Expect = 1e-69,   Method: Composition-based stats.
 Identities = 65/237 (27%), Positives = 110/237 (46%), Gaps = 25/237 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVV---MQTVRDQIGQHVFTAHRLDRPTS 58
           L I Y+DE L+ + KP+G +VH +       +         +    +     +RLD+ TS
Sbjct: 81  LSIRYEDEDLMVIAKPAGLVVHPTGNHPSGTLANGMIAYWKKRGENRKFRAVNRLDKDTS 140

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADKFAR 117
           G++++  +  A    ++  +   +Q+ Y AIV+G +  ++  ++ P+    +    +  R
Sbjct: 141 GLMIVAKNQWAHEQFSRMQQIRTLQRTYRAIVQGIVESDDGTINTPIGLAENSFITRQVR 200

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
            D   Q AVTHYR LA  E               VE++ +TGR HQ+R H++   HP+ G
Sbjct: 201 PD--GQTAVTHYRVLARGE-----------GMSFVEVKLETGRTHQIRVHMSSEGHPLAG 247

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           D  +G  R++        + R  LHA  LS  HP +G  ++    L +   Q   QF
Sbjct: 248 DDLYGGEREH--------IGRQALHAWGLSFVHPRSGLAMSWEEPLPNDMEQLAQQF 296


>UniRef50_C8X1I9 Pseudouridine synthase, RluA family n=1 Tax=Desulfohalobium
           retbaense DSM 5692 RepID=C8X1I9_DESRD
          Length = 547

 Score =  265 bits (678), Expect = 1e-69,   Method: Composition-based stats.
 Identities = 73/268 (27%), Positives = 120/268 (44%), Gaps = 27/268 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVV-MQTVRDQI----GQHVFTAHRLDRP 56
           +E++Y D  +V VNK +G  VH         +V  +  +  ++    G+     HRLD+ 
Sbjct: 91  VEVVYSDPDVVVVNKAAGVTVHPGTGCESGTLVHHLAALYPELARFDGERPGVVHRLDKD 150

Query: 57  TSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFA 116
           TSG+L + L+  A   L + F + ++ K Y  +V G    E  +D+PL  +      + A
Sbjct: 151 TSGLLTVALNESARLALTRSFARREVDKEYLTLVHGRPEAEGTVDHPLGRDPQSKI-RMA 209

Query: 117 REDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPII 176
              +G + A+T ++ + T          P  R  L+ +   TGR HQ+R H+A+L  P++
Sbjct: 210 VVPRGGKEALTRFKRVWT---------SPDGRVSLLRVRILTGRTHQIRVHMAYLGFPLV 260

Query: 177 GDSKHGDLRQNRSGAEHFGLQRL----MLHASQLSLTHPFTGEPLTIHAGLDDTWMQALS 232
           GD+ +G   Q         L RL    MLHA +L+  HP +G  +     +         
Sbjct: 261 GDALYGPQAQAAFQRSRPLLARLAKHHMLHAWRLAFPHPRSGRMVCCEQAMPKAM----- 315

Query: 233 QFGWRGLLPENERVEFSAPSGQDGEISS 260
              WR +L    RV+    +G  G   S
Sbjct: 316 ---WRLVLGCGRRVQRVGLTGMPGCGKS 340


>UniRef50_A5GW76 Pseudouridine synthase n=1 Tax=Synechococcus sp. RCC307
           RepID=A5GW76_SYNR3
          Length = 316

 Score =  265 bits (678), Expect = 1e-69,   Method: Composition-based stats.
 Identities = 65/245 (26%), Positives = 104/245 (42%), Gaps = 23/245 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIGQ----HVFTAHRLDR 55
           L++L++DE L+ +NKP+G  VH +  ++D  +V  ++    D  G          HRLD+
Sbjct: 88  LDVLFEDEHLIVINKPAGLTVHPAPGNKDGTLVNGLLHHCPDLPGISGKLRPGIVHRLDK 147

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADK 114
            T+G +++  S +A   L  Q ++    + Y A+V G    E   +   +          
Sbjct: 148 DTTGCIVIAKSQQALVKLQVQIQKRVASREYLAVVHGVPAGESGTIVGAIGRHPVDRKKY 207

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
                   + A TH+     +             Y L+  +  TGR HQ+R H AH  HP
Sbjct: 208 AVVSSDNGRYACTHWSLQERL-----------GDYSLLRFKLDTGRTHQIRVHCAHRNHP 256

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           ++GD  +   R+         L    LHA QL L HP TGE +   A L +   + L+  
Sbjct: 257 VVGDPTYSRCRKLP-----IELPGQALHAVQLGLDHPITGERMVFEAPLPEVLEKLLAVL 311

Query: 235 GWRGL 239
             R  
Sbjct: 312 RKRAA 316


>UniRef50_D1PCC3 Pseudouridine synthase n=1 Tax=Prevotella copri DSM 18205
           RepID=D1PCC3_9BACT
          Length = 387

 Score =  265 bits (678), Expect = 1e-69,   Method: Composition-based stats.
 Identities = 67/267 (25%), Positives = 116/267 (43%), Gaps = 33/267 (12%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQI-----GQHVFTAHRLD 54
           + ++Y+D+ L+ VNK +G +VH    +    ++  V   +RD          V   HR+D
Sbjct: 131 INVVYEDDQLMVVNKEAGMVVHPGAGNFHGTLIQAVAWHLRDMPEFDANDPEVGLVHRID 190

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEEL-DKIA 112
           + TSG+L++  +  A   L +QF      + Y+A+V G ++E E  ++  +  +  +++ 
Sbjct: 191 KDTSGLLVVAKTPTAKNALGKQFFNKTTHRSYNALVWGNIVEDEGRIEGNIGRDPKNRLR 250

Query: 113 DKFAREDKG-PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHL 171
            K    D G  + AVTHY+ L                  LV+   +TGR HQ+R H+ H+
Sbjct: 251 MKVFDPDSGIGKTAVTHYKVLERFGYT-----------TLVQCVLETGRTHQIRAHMKHI 299

Query: 172 RHPIIGDSKHGDLRQNRSGAEHF----------GLQRLMLHASQLSLTHPFTGEPLTIHA 221
            HP+  D  +G     R                   R  LHA  L   HP T + +   +
Sbjct: 300 GHPLFMDETYGGTEILRGQRSSSYKAFIQNCFKLCPRQALHAKTLGFVHPTTKQQMDFDS 359

Query: 222 GLDDTWMQALSQFGWRGLLPENERVEF 248
              + + Q + +  WRG +    +  F
Sbjct: 360 EWPNDFRQLIEK--WRGFIAGTTQDTF 384


>UniRef50_D0RPR1 Pseudouridine synthase n=1 Tax=alpha proteobacterium HIMB114
           RepID=D0RPR1_9RICK
          Length = 325

 Score =  264 bits (677), Expect = 1e-69,   Method: Composition-based stats.
 Identities = 60/248 (24%), Positives = 115/248 (46%), Gaps = 21/248 (8%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIG-----QHVFTAHRLD 54
           L I+++D+ ++ ++KP G +VH    + ++ +V  ++   ++ +            HR+D
Sbjct: 81  LNIIFEDQDIIIIDKPIGMVVHPGAGNYEDTMVNGLLYHCKNNLSGMNGEDRPGIVHRID 140

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIAD 113
           + TSG+L++  + +A   +A+QFE+H I++ Y   V G L      ++  +         
Sbjct: 141 KDTSGLLVVAKNDQAHAFIAKQFEEHSIKRSYLVFVYGILRPLHGKIETLIGRNKTN-RQ 199

Query: 114 KFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
           K + +    + A+T+Y  L   +              LV+   +TGR HQ+R H++H  +
Sbjct: 200 KMSADVIRGKDAITNYETLEVFK------GNKIPDISLVKCILETGRTHQIRVHMSHKGN 253

Query: 174 PIIGDSKHGDLRQNRSGAEHF------GLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTW 227
           PI+GD  +G   +   G +         L+R  LHA  L   HP T E +   + L D  
Sbjct: 254 PILGDQTYGKKIKKIRGIDQEFEEILKSLKRQALHAHTLGFIHPTTNEEVFFASELPDDL 313

Query: 228 MQALSQFG 235
            +  ++  
Sbjct: 314 NKLKNRLE 321


>UniRef50_D0KVM5 Pseudouridine synthase n=11 Tax=Proteobacteria RepID=D0KVM5_HALNC
          Length = 340

 Score =  264 bits (677), Expect = 2e-69,   Method: Composition-based stats.
 Identities = 63/242 (26%), Positives = 109/242 (45%), Gaps = 22/242 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG---QHVFTAHRLDRPTS 58
           L+I+Y+D+ ++ +NK    +VH +  + D  +V      D            HRLD+ TS
Sbjct: 81  LDIIYEDDAIIVLNKSPDIVVHPAAGNPDGTLVNALLFHDPSLVSVPRAGVVHRLDKQTS 140

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           GV+++  +  A ++L +     +I++ Y  +V G ++    +D P+         +    
Sbjct: 141 GVMVVAKTLAAHKILVENLAARKIRREYDTVVMGHVVAGGTVDAPIGRHPRDRQRQAVT- 199

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
               + AVTHYR L                   + ++ +TGR HQ+R H+AH+RHP+IGD
Sbjct: 200 -ATGKRAVTHYRVLQHY-----------GEQTWLRVQLETGRTHQIRVHMAHIRHPVIGD 247

Query: 179 SKHGDLRQNRSGAEHFGLQ------RLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALS 232
             +G   +    A    +       R  LHA  L+L HP TG  +   A + D   + ++
Sbjct: 248 PVYGGRPRIPPRASTALIDVLRHFERQALHARYLTLAHPVTGTQMRFEAPMPDDMRELIA 307

Query: 233 QF 234
             
Sbjct: 308 LL 309


>UniRef50_O50310 Uncharacterized RNA pseudouridine synthase Cpar_0723 n=13
           Tax=Chlorobiaceae RepID=Y723_CHLP8
          Length = 327

 Score =  264 bits (676), Expect = 2e-69,   Method: Composition-based stats.
 Identities = 64/253 (25%), Positives = 105/253 (41%), Gaps = 31/253 (12%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVR--------DQIGQHVFTAHRL 53
           + ILY+D+ L+ ++K +G +VH ++ +    +               D+        HRL
Sbjct: 77  ITILYEDDDLMVIDKEAGMVVHPAFGNWTGTLANAILHHLGKDADELDKTEMRPGIVHRL 136

Query: 54  DRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIA 112
           D+ TSG++++  +  A   LA+QF   Q++K Y AIV G    E   +   +        
Sbjct: 137 DKDTSGLIIIAKNPTALHKLARQFANRQVEKVYKAIVWGVPKAESGTIKTNIGRSHKNRK 196

Query: 113 DKFAREDKG--PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAH 170
                  +G   + A+T Y+ +  +             + L+++   TGR HQ+R HL H
Sbjct: 197 VMANFPYEGAEGKHAITDYQVVEDLGY-----------FSLMDVTLHTGRTHQIRVHLQH 245

Query: 171 LRHPIIGDSKHGDLRQNRSGAEH---------FGLQRLMLHASQLSLTHPFTGEPLTIHA 221
           L H I+GD  +G                      + R  LHA  L    P TGEPL+  A
Sbjct: 246 LGHSILGDETYGGATPRTLPFSKSEPFTRNLLELMSRQALHAQTLRFRQPTTGEPLSFSA 305

Query: 222 GLDDTWMQALSQF 234
            L +     L + 
Sbjct: 306 PLPEDMELVLEKI 318


>UniRef50_B0VJ94 Pseudouridine synthase n=1 Tax=Candidatus Cloacamonas
           acidaminovorans RepID=B0VJ94_9BACT
          Length = 351

 Score =  263 bits (674), Expect = 3e-69,   Method: Composition-based stats.
 Identities = 68/252 (26%), Positives = 113/252 (44%), Gaps = 32/252 (12%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG-------QHVFTAHRLD 54
           L+++Y+DE+L  +NK +G +VH  + + +  +V     R                 HRLD
Sbjct: 89  LDVVYEDEYLAIINKKAGMIVHPGFGNPEGTLVNAILYRFGENLSSGKEFNRPGIVHRLD 148

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIAD 113
           R TSG++++  +      L+  F + +I+K Y AI  G    E+  ++  L         
Sbjct: 149 RGTSGLIIIAKNDLTHAKLSDMFARREIKKTYFAITTGIPEPEKGEIETYLAR--SNKNP 206

Query: 114 KFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
           +        + A+THY+ + T              + LVE+ P TGR HQ+R H AH+R+
Sbjct: 207 RTICVTNEGRYALTHYKTIKTWHY-----------FALVEINPATGRMHQIRVHFAHIRY 255

Query: 174 PIIGDSKHGDLRQNRSGAEH-----------FGLQRLMLHASQLSLTHPFTGEPLTIHAG 222
           PI+GD  +   R  +S                 L+R  LH+ +L   HP TG P+++ A 
Sbjct: 256 PILGDLLYNSRRYVQSLVPQNMKKKVTELLVNHLRRQALHSWKLEFFHPITGYPISVSAP 315

Query: 223 LDDTWMQALSQF 234
           + D     L+  
Sbjct: 316 IPDDIQYTLNWL 327


>UniRef50_C6JBH1 Pseudouridine synthase n=1 Tax=Ruminococcus sp. 5_1_39BFAA
           RepID=C6JBH1_9FIRM
          Length = 299

 Score =  263 bits (674), Expect = 3e-69,   Method: Composition-based stats.
 Identities = 63/233 (27%), Positives = 110/233 (47%), Gaps = 23/233 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVV-MQTVRDQIGQHV--FTAHRLDRPTS 58
           L I+Y+DE ++ +NKP+   VH S  + +  +   +     + G+       +RLDR T+
Sbjct: 81  LNIIYEDEDILVINKPADMPVHPSAGNYENTLANGIAWYFAEKGEDFVYRCINRLDRDTT 140

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           G L++  +  +  +L+ Q ++ QI + Y A+V G L +   ++ P+      +  +    
Sbjct: 141 GALILAKNPLSAAILSVQMKKRQILRTYLALVDGLLPDSGTINAPIARMEGSVITREVNF 200

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
               + A+THY  LA               Y L EL  +TGR HQ+R H+ ++ HP+ GD
Sbjct: 201 -GTGESAITHYERLA-----------AGKEYSLAELHLETGRTHQIRVHMKYIGHPLPGD 248

Query: 179 SKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
             +          ++  + R  LH+ QL  THP TG+ +   A L   ++ A 
Sbjct: 249 YLYN--------PDYRRINRQPLHSYQLEFTHPTTGKVMLFTAPLPIDFISAF 293


>UniRef50_Q8ZQ16 Ribosomal large subunit pseudouridine synthase C n=110
           Tax=Gammaproteobacteria RepID=RLUC_SALTY
          Length = 319

 Score =  263 bits (674), Expect = 3e-69,   Method: Composition-based stats.
 Identities = 75/233 (32%), Positives = 116/233 (49%), Gaps = 14/233 (6%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLM 63
           ILY+D+ ++ +NKPSG  VH         +  ++ +R +  + +   HRLDR TSGVLL+
Sbjct: 95  ILYEDDHILVLNKPSGTAVHGGSGLSFGVIEGLRALRPE-ARFLELVHRLDRDTSGVLLV 153

Query: 64  GLSSEAGRLLAQQFEQHQIQKRYHAIVRG-WLMEEAVLDYPLVEELDKIADKFAREDKGP 122
                A R L +Q  +  +QK Y A+VRG W      +  PL++ + +  ++  R  +  
Sbjct: 154 AKKRSALRSLHEQLREKGMQKDYLALVRGQWQSHVKTVQAPLLKNILQSGERIVRVSQEG 213

Query: 123 QPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHG 182
           +P+ T ++                    LV   P TGR HQ+R H  +  HPI  D ++G
Sbjct: 214 KPSETRFKVEERYAF-----------ATLVRCSPVTGRTHQIRVHTQYAGHPIAFDDRYG 262

Query: 183 DLRQNRSGAEH-FGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           D   ++   E   GL+RL LHA+ L  THP TGE + I A +D+   + L   
Sbjct: 263 DREFDQQLTEAGTGLKRLFLHAAALKFTHPGTGEVMRIEAPMDNALKRCLQVL 315


>UniRef50_C7RM94 Pseudouridine synthase n=11 Tax=Proteobacteria RepID=C7RM94_9PROT
          Length = 375

 Score =  263 bits (672), Expect = 7e-69,   Method: Composition-based stats.
 Identities = 60/241 (24%), Positives = 111/241 (46%), Gaps = 18/241 (7%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV---VMQTVRDQIGQHVFTAHRLDRPTS 58
           L I+++D+ L+ ++K +G +VH    +    ++   +    +          HRLD+ T+
Sbjct: 107 LRIVFEDDTLIVLDKQAGLVVHPGSGNWRGTLLNGLLHHAPQLARVPRAGIVHRLDKDTT 166

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           G++++  + EA   L +Q +   +++ Y A+VRG +    ++D P+      +  + A  
Sbjct: 167 GLMVVAKTLEAQTDLVRQLQARSVKRCYQALVRGIVEGAGIVDAPIGRHP-TVRTRMAVV 225

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
             G +PA THYR L                  L+E   +TGR HQ+R H+  + HP++GD
Sbjct: 226 S-GGRPARTHYRVLERFVAC-----------TLIECALETGRTHQIRVHMTSIAHPLVGD 273

Query: 179 SKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWRG 238
             +G           F   R  LHA +L+L HP +G+ +   +G+       + +     
Sbjct: 274 PIYGGGASRVPQGAVF--PRQALHACRLALVHPASGKAMLWRSGVPADMAALIDRLRLES 331

Query: 239 L 239
           L
Sbjct: 332 L 332


>UniRef50_Q5QZ45 Pseudouridine synthase n=2 Tax=Gammaproteobacteria
           RepID=Q5QZ45_IDILO
          Length = 315

 Score =  262 bits (670), Expect = 9e-69,   Method: Composition-based stats.
 Identities = 78/232 (33%), Positives = 115/232 (49%), Gaps = 14/232 (6%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLM 63
           ILY+D+ L+ +NKPSG  VH     +   +  ++ +R +  + +   HR+DR TSG+LL+
Sbjct: 94  ILYEDDALMLINKPSGVAVHGGSGLQFGLIEGLRALRPK-EKSLELVHRIDRDTSGLLLV 152

Query: 64  GLSSEAGRLLAQQFEQHQIQKRYHAIVRG-WLMEEAVLDYPLVEELDKIADKFAREDKGP 122
                  R L +Q    ++ K+Y A+VRG W      ++ PL +   K  ++  R D   
Sbjct: 153 AKKRSVLRSLHEQLRNKEMNKQYLALVRGQWQKRVRSVEAPLKKNTLKSGERIVRVDAEG 212

Query: 123 QPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHG 182
           + ++T +R     +              LVE  P TGR HQ+R H  H  HPI  D K+G
Sbjct: 213 KASLTRFRIQQRYKEG-----------TLVEASPVTGRTHQIRVHALHAGHPIAKDPKYG 261

Query: 183 DLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           D   + + +   GL RL LHA QL   HP TG+ +   A LDD   Q L Q 
Sbjct: 262 DTDFDNTMS-RLGLNRLFLHAWQLRFLHPVTGKEVAFEAPLDDNLQQTLKQL 312


>UniRef50_C1ZGS9 Pseudouridine synthase n=1 Tax=Planctomyces limnophilus DSM 3776
           RepID=C1ZGS9_PLALI
          Length = 345

 Score =  262 bits (670), Expect = 1e-68,   Method: Composition-based stats.
 Identities = 71/258 (27%), Positives = 112/258 (43%), Gaps = 28/258 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKV-----VVMQTVRDQIGQ-HVFTAHRLDR 55
           L+ILY DE+L  +NK +  +VH    +    +         ++ D  GQ      HRLDR
Sbjct: 91  LDILYDDEYLCVINKTANMIVHPGRGNYRGTLAGALQFHFDSLSDVAGQYRAGIVHRLDR 150

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADK 114
            TSGVL++   +   + L++QFE+  ++K YHAIV G +  +   ++  +          
Sbjct: 151 DTSGVLVVAKDNTVHQHLSRQFEERSVEKEYHAIVWGEMQFDADYVETYVRVSFRNRERM 210

Query: 115 FAREDK-GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
                    + A T Y                   +  V+L+P+TGR HQLR H+ HL H
Sbjct: 211 MVCPPGDNARQAATFYEVQQRFR-----------GFTYVKLQPQTGRTHQLRVHMHHLGH 259

Query: 174 PIIGDSKH-GD--------LRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLD 224
           PII D  + G         L +    A+   + R  LHA +L+  HP T + +   A L 
Sbjct: 260 PIIADRLYEGKTCVKLSDILPETPEEADETLIDRQALHARRLAFNHPVTKKRMVFEAPLP 319

Query: 225 DTWMQALSQFGWRGLLPE 242
             + + L       + P+
Sbjct: 320 ADFQKTLDTLKTHAIKPK 337


>UniRef50_Q1J0S8 Pseudouridine synthase n=7 Tax=Deinococci RepID=Q1J0S8_DEIGD
          Length = 341

 Score =  262 bits (670), Expect = 1e-68,   Method: Composition-based stats.
 Identities = 87/263 (33%), Positives = 119/263 (45%), Gaps = 33/263 (12%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVR----------DQIGQHVFTAH 51
           L++LY+DE L+AVNKP G + H +       +V     R             G      H
Sbjct: 97  LDVLYEDEHLIAVNKPPGMVTHPAPGVTSGTLVNALLGRLTLPEQPGAVGPDGYRPGIVH 156

Query: 52  RLDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEA--VLDYPLVEELD 109
           RLD+ TSGV+++  + EA   LA  F+     K Y AI  G    +    ++ P+     
Sbjct: 157 RLDKDTSGVIVVAKTVEAHARLAAAFKDRSTHKTYLAIAAGMWKAQGPVSVNAPVGRHP- 215

Query: 110 KIADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLA 169
               +      GP+ A T +  LAT   P   GR       LV  +P TGR HQ+R HLA
Sbjct: 216 TARQRMTVGGVGPREAQTLFTPLAT--HPDGHGR----TLALVRAQPHTGRTHQIRVHLA 269

Query: 170 HLRHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQ 229
           HL  PI+GD+ +G             + R  LHA  L+L HP TGE L +HA + D  ++
Sbjct: 270 HLGSPILGDAVYG--------RASAVMPRHALHAQFLTLPHPVTGETLHLHAPVPDDLLR 321

Query: 230 ALSQFGWRGLLPENERVEFSAPS 252
           A    G  G +P     E  APS
Sbjct: 322 AWVALG--GAVP----AELEAPS 338


>UniRef50_Q2SS88 Pseudouridine synthase n=4 Tax=Mollicutes RepID=Q2SS88_MYCCT
          Length = 322

 Score =  262 bits (670), Expect = 1e-68,   Method: Composition-based stats.
 Identities = 59/240 (24%), Positives = 109/240 (45%), Gaps = 25/240 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRD------QIGQHVFTAHRLDR 55
           L I+YQD+ L+ +NK +   VH S  + +  +V      D               HR+D+
Sbjct: 95  LNIIYQDDDLLVINKQNNITVHPSLNNTNNTIVNALLASDVELSSINGELRPGIVHRIDK 154

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADK 114
            T+G+L++  + +  +LL++ F+ HQI K Y AIV G +   + ++D P+         K
Sbjct: 155 QTTGLLIVAKNDKTHKLLSEMFKNHQIYKEYLAIVTGVIKPNKGLIDAPIGRSQTD-RKK 213

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
            +   K  + A+T +  +               +  L++ + +TGR HQ+R H  ++ HP
Sbjct: 214 MSVTAKNSKHAITTFEVVERF-----------LKNTLIKCQIQTGRTHQIRVHFNYINHP 262

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           ++ D  +G   Q  +           LHA +L  THP T + + + + L   +   + + 
Sbjct: 263 VLNDPIYGKKHQEFTDF------GQYLHAYKLKFTHPITKKEIELISPLPKEFDDKIKEL 316


>UniRef50_D1BAB3 Pseudouridine synthase n=1 Tax=Thermanaerovibrio acidaminovorans
           DSM 6589 RepID=D1BAB3_THEAS
          Length = 320

 Score =  261 bits (669), Expect = 1e-68,   Method: Composition-based stats.
 Identities = 67/236 (28%), Positives = 108/236 (45%), Gaps = 24/236 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG------QHVFTAHRLDR 55
             ++YQD+ LV V+KP+G +VH +       +V     R          +     HRLD 
Sbjct: 96  FRVVYQDQDLVVVDKPAGLVVHPAPGHWRGTLVHGLLYRYPDLMELNGVKRPGIVHRLDA 155

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKF 115
            TSG++++  +  A   L + F+  ++ K Y A+  G L  E  +  P+  + D    + 
Sbjct: 156 TTSGLMVVARNGLAMEGLVRAFKDRRVGKVYLAMAAGTLRGEGSVSLPIGRDPDN-RKRM 214

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
           A    G + A+T YR +           +    Y LV  + KTGR HQ+R H+  L HP+
Sbjct: 215 ACVPWG-REALTRYRVI-----------WSRGGYSLVACQIKTGRTHQIRVHMRSLGHPL 262

Query: 176 IGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
           +GD  +G         E F L R+ LH+ +L   HP TG P++    L    ++ +
Sbjct: 263 VGDRIYGG-----PCPEGFPLGRVFLHSWRLEFDHPRTGAPMSFICPLPPDLVRFI 313


>UniRef50_B8GZR6 Pseudouridine synthase n=2 Tax=Caulobacter vibrioides
           RepID=B8GZR6_CAUCN
          Length = 342

 Score =  261 bits (669), Expect = 1e-68,   Method: Composition-based stats.
 Identities = 69/237 (29%), Positives = 95/237 (40%), Gaps = 18/237 (7%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG-------QHVFTAHRLD 54
           L ILY+D  L+ V+K +G  VH +    +  +V                       HRLD
Sbjct: 103 LSILYEDAHLIVVDKAAGMAVHPAPGTYNGTLVNALLHHCGASLSGVGGVARPGIVHRLD 162

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIAD 113
           + TSGV++   S  A R L+  F  H I + Y A+ RG        +   +         
Sbjct: 163 KDTSGVMVAAKSDAAHRGLSTLFATHDIDRLYVALTRGAPNPPTGTIQTQIGRSPGD-RK 221

Query: 114 KFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
           K A    G + A+THYR  A        G         V    +TGR HQ+R H+A    
Sbjct: 222 KMAVLRAGGREAITHYRVEAAF------GPADRPLAARVACRLETGRTHQIRVHMASKGS 275

Query: 174 PIIGDSKHGDLRQNRSGAEHF---GLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTW 227
           P +GD  +G  +   +  E     GL+R  LHA+ L   HP TGE L     L    
Sbjct: 276 PCLGDPVYGAAQPAAAVRERIEAAGLRRQALHAAVLGFVHPITGETLRFETPLPADM 332


>UniRef50_A1AW00 Pseudouridine synthase n=2 Tax=sulfur-oxidizing symbionts
           RepID=A1AW00_RUTMC
          Length = 314

 Score =  261 bits (668), Expect = 2e-68,   Method: Composition-based stats.
 Identities = 61/243 (25%), Positives = 106/243 (43%), Gaps = 22/243 (9%)

Query: 1   MLEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRD---QIGQHVFTAHRLDRPT 57
           +++++Y+DE ++ VNKP   + H    +    +       D            HRLD+ T
Sbjct: 79  VIDVVYEDEAIIIVNKPVNLVTHPGVSNWTGTLANALLHYDSSLANLDRAGIVHRLDKNT 138

Query: 58  SGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAR 117
           SG++++  S  A + L +Q + H I + Y AIV G ++    +D P+  +      +   
Sbjct: 139 SGLMVVARSEYAQKYLTRQLQTHSISREYSAIVYGHMISGGTVDKPIGRDPKDRIRQTVT 198

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
           E    + A+THYR +                +  V++  +TGR HQ+R HL+ + HP+I 
Sbjct: 199 ES--GKDALTHYRVIERF-----------AHHTHVKVMLETGRTHQIRVHLSFIGHPLIA 245

Query: 178 DSKHGDLRQNRSGAEH------FGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
           D  +G   +    A+           R  LHA +L+L HP + E ++    L       L
Sbjct: 246 DPMYGGKIRFPKKADKQLKNSLKNFNRQTLHAKKLTLIHPTSTELMSWKVPLPQDMQDLL 305

Query: 232 SQF 234
              
Sbjct: 306 QVL 308


>UniRef50_A0Q1S9 Pseudouridine synthase n=32 Tax=Clostridium RepID=A0Q1S9_CLONN
          Length = 301

 Score =  261 bits (668), Expect = 2e-68,   Method: Composition-based stats.
 Identities = 67/237 (28%), Positives = 115/237 (48%), Gaps = 24/237 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQH---VFTAHRLDRPTS 58
           L+++Y+D+ +V +NKP G +VH +   ++  +        +       V   +RLD  TS
Sbjct: 83  LDVIYEDKDIVVINKPKGIVVHPTKRHQNGTLSNGVLYYFKEKNENSIVRLVNRLDMDTS 142

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADKFAR 117
           G++L+  ++ +   L++  ++    K Y AIV G L E+  V++ P+    +    +   
Sbjct: 143 GLVLIAKNAYSHMALSRDMQKDDFVKSYLAIVHGNLKEKSGVINKPIYRVGEGTLRRVI- 201

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
            D+  Q +VT ++ + + E              LVEL  +TGR HQ+R HL+ + HPI G
Sbjct: 202 -DERGQRSVTRFKVVESYEDAD-----------LVELTLETGRTHQIRVHLSSIGHPIYG 249

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           DS +G         EH  + R  LHA +L + HP  G  L + + L D     +S+ 
Sbjct: 250 DSLYGK-------EEHEYIDRQALHAYKLQIPHPKDGRILKLESDLPDDMKNLISKL 299


>UniRef50_P54604 Uncharacterized RNA pseudouridine synthase yhcT n=5 Tax=Bacillus
           RepID=YHCT_BACSU
          Length = 302

 Score =  260 bits (666), Expect = 3e-68,   Method: Composition-based stats.
 Identities = 70/237 (29%), Positives = 110/237 (46%), Gaps = 23/237 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG---QHVFTAHRLDRPTS 58
           L+IL++D  ++ +NKP+G   H +   +   +  +     QI      V   HRLD+ TS
Sbjct: 83  LDILFEDNHMLIINKPAGIATHPNEDGQTGTLANLIAYHYQINGETCKVRHVHRLDQDTS 142

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADKFAR 117
           G ++      A  +L QQ E+  +++ Y AI  G L  ++  ++ P+  +      +  R
Sbjct: 143 GAIVFAKHRLAHAILDQQLEKKTLKRTYTAIAEGKLRTKKGTINSPIGRDRSHPTRR--R 200

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
              G Q AVTH++ +A+             R  LVELE +TGR HQ+R HLA L HP+ G
Sbjct: 201 VSPGGQTAVTHFKVMAS---------NAKERLSLVELELETGRTHQIRVHLASLGHPLTG 251

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           DS +G   +         L R  LHA+++   HP T E +   A            +
Sbjct: 252 DSLYGGGSK--------LLNRQALHANKVQAVHPITDELIVAEAPFPADMKNLCRTY 300


>UniRef50_A9NGF1 Pseudouridine synthase n=1 Tax=Acholeplasma laidlawii PG-8A
           RepID=A9NGF1_ACHLI
          Length = 297

 Score =  260 bits (666), Expect = 3e-68,   Method: Composition-based stats.
 Identities = 69/242 (28%), Positives = 115/242 (47%), Gaps = 28/242 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVR-------DQIGQHVFTAHRLD 54
           L I+Y+D+ ++ +NKP G +VH S    +  +V             +         HR+D
Sbjct: 76  LNIVYEDDDIMVINKPKGLVVHPSETFSETTLVSGLLHHTDTLSTHNDDPLRPGILHRID 135

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIAD 113
           + TSG++L+  ++EA ++LAQ  + H I++ Y A+V G L   + V+D P+     KI  
Sbjct: 136 KDTSGLILVAKTNEAHKILAQDLKSHDIKREYIALVEGVLDHNKGVIDAPIARHP-KIRT 194

Query: 114 KFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
           K A      +PA+TH+  + T              + L+  + +TGR HQ+R HLA+++H
Sbjct: 195 KMAVV-ATGKPAITHFEVMRTFR-----------DHTLLHCKLETGRTHQIRVHLAYIKH 242

Query: 174 PIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           P+ GD  +G                 +LHA +L   HP T + + + A L   +   L  
Sbjct: 243 PVTGDPLYGTKA-------KILKDGQLLHAFRLEFVHPITKKVMMLEAPLPPEFESYLVT 295

Query: 234 FG 235
            G
Sbjct: 296 LG 297


>UniRef50_D1N7N8 Pseudouridine synthase, RluA family n=1 Tax=Victivallis vadensis
           ATCC BAA-548 RepID=D1N7N8_9BACT
          Length = 323

 Score =  260 bits (666), Expect = 3e-68,   Method: Composition-based stats.
 Identities = 70/246 (28%), Positives = 111/246 (45%), Gaps = 20/246 (8%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQ--------IGQHVFTAHRL 53
             ILY+D+ ++ ++KP+G +VH +  +    VV     R                  HRL
Sbjct: 83  FPILYEDDVMLVIDKPAGVVVHPAAGNPTGTVVNALLGRYPQLAEQLACTTSRPGIVHRL 142

Query: 54  DRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIAD 113
           D+ TSG L +  ++ A   L+  F   + +K Y AI RG  +  +     L+        
Sbjct: 143 DKDTSGCLAVAKTANAQFKLSTAFAGRETRKTYLAITRGVPIRRSGELSTLIGRHPVSRQ 202

Query: 114 KFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
           K A  ++  + A+T YR          TG       G++ +   TGR HQ+R HLA L  
Sbjct: 203 KMAVVERNGKLAITRYRV-------EYTGMLDGVEIGVLAVRILTGRTHQIRVHLASLGV 255

Query: 174 PIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           P++GD+ +G  R   +G E     R +LHA +L + HP TG P+   A   +   + L +
Sbjct: 256 PVLGDAVYGGARTAVAGVE-----RQLLHAWKLCVPHPATGTPMEFTAPPPEDIRRILER 310

Query: 234 FGWRGL 239
            G + L
Sbjct: 311 IGVKTL 316


>UniRef50_Q8K9E9 Ribosomal large subunit pseudouridine synthase D n=4 Tax=Buchnera
           aphidicola RepID=RLUD_BUCAP
          Length = 315

 Score =  260 bits (666), Expect = 3e-68,   Method: Composition-based stats.
 Identities = 57/240 (23%), Positives = 110/240 (45%), Gaps = 23/240 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRD---QIGQHVFTAHRLDRPTS 58
           L  +Y+D  ++ +NKP G +VH    ++D  ++     R             HRLD+ TS
Sbjct: 84  LNTIYEDSNILIINKPPGLVVHPGAGNQDGTILNALLYRYTNISSIPRCGIIHRLDKDTS 143

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           G++++  +  +   L    ++ +I ++Y  I++G ++   +++YP++             
Sbjct: 144 GLMVIAKTIFSYNKLVTLLKKRKIIRKYQGIIKGNMISGGIVNYPIMRHP--FKRICMTT 201

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
           D   + ++THY+ +   +            +  V    +TGR HQ+R H+ H+ +P++GD
Sbjct: 202 DSLGKKSITHYKIINRFKF-----------HTHVSFRLETGRTHQIRVHMLHIGYPLLGD 250

Query: 179 SKHGD-------LRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
             +G         ++NR+    F L R  LHA  +   HPFT + ++  A L       L
Sbjct: 251 PLYGGIDYGCNYFQENRNIYRKFNLFRQALHADYIEFIHPFTQKVMSWSASLPQDMKDIL 310


>UniRef50_Q13E92 Pseudouridine synthase n=28 Tax=Alphaproteobacteria
           RepID=Q13E92_RHOPS
          Length = 426

 Score =  260 bits (666), Expect = 3e-68,   Method: Composition-based stats.
 Identities = 68/252 (26%), Positives = 114/252 (45%), Gaps = 26/252 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG-------QHVFTAHRLD 54
           LEI+++D+ ++ ++KP G +VH +       +V                 +     HRLD
Sbjct: 178 LEIVHEDDDIIVIDKPRGLVVHPAAGHETGTLVNALIAHCGESLSGIGGVRRPGIVHRLD 237

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQH----QIQKRYHAIVRGWLME-EAVLDYPLVEELD 109
           + T+G+++   +  A + L+ QF  H    ++++ Y+A V G        +D P+     
Sbjct: 238 KDTTGLMVAAKNDRAHQSLSAQFADHGRTGELRRGYYAFVWGAPNRIRGTIDAPIDRHPH 297

Query: 110 KIADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLA 169
                  R+  G + A+TH+  L T      TGR       L+  + +TGR HQ+R HLA
Sbjct: 298 AREKMAVRD--GGREAITHWEVLETF-----TGRSGGEIVSLIACQLETGRTHQIRVHLA 350

Query: 170 HLRHPIIGDSKHGDLRQNRSG-------AEHFGLQRLMLHASQLSLTHPFTGEPLTIHAG 222
           H+ HP++GD  +G   + ++        A    L R  LHA  L L HP TGE +   +G
Sbjct: 351 HIGHPLLGDDVYGPHFKTKASQLRPDARAALTDLGRQALHAYLLVLEHPSTGEVVAWESG 410

Query: 223 LDDTWMQALSQF 234
           L     +  +  
Sbjct: 411 LPADLKRLKAAL 422


>UniRef50_P65834 Ribosomal large subunit pseudouridine synthase D n=321
           Tax=Gammaproteobacteria RepID=RLUD_ECOL6
          Length = 326

 Score =  260 bits (665), Expect = 4e-68,   Method: Composition-based stats.
 Identities = 62/240 (25%), Positives = 108/240 (45%), Gaps = 22/240 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQI---GQHVFTAHRLDRPTS 58
           L+I+Y+DE ++ +NKP   +VH    + D  V+                   HRLD+ T+
Sbjct: 84  LDIVYEDEDIIVINKPRDLVVHPGAGNPDGTVLNALLHYYPPIADVPRAGIVHRLDKDTT 143

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           G++++  +  A   L +  ++ +I + Y A+  G +     +D P+     K        
Sbjct: 144 GLMVVAKTVPAQTRLVESLQRREITREYEAVAIGHMTAGGTVDEPISRHPTKRTHMAV-- 201

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
               +PAVTHYR +    +           +  + L  +TGR HQ+R H+AH+ HP++GD
Sbjct: 202 HPMGKPAVTHYRIMEHFRV-----------HTRLRLRLETGRTHQIRVHMAHITHPLVGD 250

Query: 179 SKHGDLRQNRSGAEHFGL------QRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALS 232
             +G   +   GA    +       R  LHA+ L L HP +G  +  HA +    ++ + 
Sbjct: 251 PVYGGRPRPPKGASEAFISTLRKFDRQALHATMLRLYHPISGIEMEWHAPIPQDMVELIE 310


>UniRef50_Q126H9 Pseudouridine synthase n=1 Tax=Polaromonas sp. JS666
           RepID=Q126H9_POLSJ
          Length = 378

 Score =  259 bits (664), Expect = 4e-68,   Method: Composition-based stats.
 Identities = 77/244 (31%), Positives = 118/244 (48%), Gaps = 17/244 (6%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
             +L++D++L+A++KP+G  VH         +  ++  R Q    +   HRLDR TSG+L
Sbjct: 126 FPVLFEDDFLLAIDKPAGVAVHGGSGVSFGVIEQLRMARPQ-ADFLELVHRLDRETSGIL 184

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRG-WLMEEAVLDYPLVE--------ELDKIA 112
           L+     A +LL +QF + +  K Y A+V G W     V+D  L +        E ++  
Sbjct: 185 LIAKRRMALKLLQEQFRERETDKVYLALVSGNWPANHRVIDKALHKYLLPGGAGEGERRV 244

Query: 113 DKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLR 172
                +      +VT  +  +      A    P T + L+E+  KTGR HQ+R HLA+  
Sbjct: 245 KVVPNDHPDGMRSVTLVKVKSAFAALPAA---PGTPFTLLEVTIKTGRTHQIRVHLANEG 301

Query: 173 HPIIGDSKHGDLRQNRSGAEHF----GLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWM 228
           HPI GD K+GD   N+S  +       L+R+ LHA  L   HP T + + +   L D   
Sbjct: 302 HPIAGDDKYGDFELNKSLQKSVAGGAPLKRMFLHAWSLKFNHPKTRKTIHLETPLPDELQ 361

Query: 229 QALS 232
           Q LS
Sbjct: 362 QFLS 365


>UniRef50_A0L8J2 Pseudouridine synthase n=1 Tax=Magnetococcus sp. MC-1
           RepID=A0L8J2_MAGSM
          Length = 328

 Score =  259 bits (664), Expect = 5e-68,   Method: Composition-based stats.
 Identities = 79/237 (33%), Positives = 125/237 (52%), Gaps = 15/237 (6%)

Query: 5   LYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG--QHVFTAHRLDRPTSGVLL 62
           L++D W++ +NKP+G  VH     +   V  ++   +++G        HRLD+ TSG+LL
Sbjct: 101 LHRDGWILVLNKPAGIPVHGGSGHQWGVVDAVRASLEKLGIEAQAELCHRLDKETSGLLL 160

Query: 63  MGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADKFAREDKG 121
            GL   A RLL +   ++Q+ K Y  +V+G     + V++ PL +   +  ++    ++G
Sbjct: 161 FGLRPRAVRLLTEAMRENQVTKTYLTLVQGVPAARQGVINQPLSKGNVRGGERMVVVEQG 220

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
            Q AVTHYR L +  +             L+E++ +TGR HQ+R H+  L HP+ GD K+
Sbjct: 221 GQRAVTHYRVLRSYGV-----------ASLLEVQLETGRTHQIRVHMQWLGHPVAGDGKY 269

Query: 182 GDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWRG 238
           GD   N+   E  GL+RL LHAS+L+  HP   + L   A LDD   + L     + 
Sbjct: 270 GDKAFNKWMRER-GLKRLFLHASELAFRHPENEQKLAYQAPLDDELTRVLEGLKRQE 325


>UniRef50_B7GAM3 Predicted protein (Fragment) n=1 Tax=Phaeodactylum tricornutum CCAP
           1055/1 RepID=B7GAM3_PHATR
          Length = 325

 Score =  259 bits (664), Expect = 6e-68,   Method: Composition-based stats.
 Identities = 68/234 (29%), Positives = 111/234 (47%), Gaps = 11/234 (4%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVR-----DQIGQHVFTAHRLDRP 56
           L+I+++DE ++ +NK +  +VH +  + D  VV           + I       HRLD+ 
Sbjct: 73  LDIIFEDEHMIVINKAANMVVHPAAGNWDGTVVNALAYYLANRSESISFRPGIVHRLDKG 132

Query: 57  TSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFA 116
           T+GVL++  +S+    L+  F   Q++K Y AI  G   +  V+D P+            
Sbjct: 133 TTGVLVVAKTSQTLATLSNFFAARQVKKTYMAITVGNPGKHVVIDKPIGRHPLHRQRMRV 192

Query: 117 REDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPII 176
             D   + + T  R L+ V+     G+       LV++  +TGR HQ+R HL     PI 
Sbjct: 193 VPDPHQKNS-TGRRALSYVDTLAFDGKL-----SLVQVRIETGRTHQIRVHLQDRHTPIY 246

Query: 177 GDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQA 230
           GD  +G    N+  ++   + R +LHA +L + HP TGEP+   A L D   + 
Sbjct: 247 GDDIYGLADWNKKLSKTHRIVRPLLHAYKLEINHPVTGEPMVFKASLADDMKRI 300


>UniRef50_B9YI75 Pseudouridine synthase, RluA family n=1 Tax='Nostoc azollae' 0708
           RepID=B9YI75_ANAAZ
          Length = 329

 Score =  259 bits (663), Expect = 6e-68,   Method: Composition-based stats.
 Identities = 68/245 (27%), Positives = 115/245 (46%), Gaps = 24/245 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIG----QHVFTAHRLDR 55
           L+ILY+DE L+ +NKP+G +VH +    D  +V  ++    +  G    Q     HRLD+
Sbjct: 99  LDILYEDEQLLILNKPAGLVVHPAPGHLDGTLVNALLAHCANLPGIGGVQRPGIVHRLDK 158

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEEL-DKIAD 113
            T+G + +  +  A + L  Q +    ++ Y  +V G    E  +++ P+     D+   
Sbjct: 159 DTTGAIAIAKTDIAYQHLQAQLQAKTARREYLGVVYGVPKTESGIINLPISRHPQDRKKM 218

Query: 114 KFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
                ++G + A+TH++    +           + Y L+  + +TGR HQ+R H A + H
Sbjct: 219 AIVPTEQGGRTAITHWQIRERL-----------SNYTLIHFQLETGRTHQIRVHSAKIGH 267

Query: 174 PIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           PI+GDS +G  R     +    L    LHA QL L HP +G+ + + A    T+   L  
Sbjct: 268 PIVGDSVYGAGR-----SVGVNLAGHALHAWQLKLQHPISGDWIQVTASPPQTFTTLLEV 322

Query: 234 FGWRG 238
              R 
Sbjct: 323 LRRRS 327


>UniRef50_C7LP91 Pseudouridine synthase n=1 Tax=Desulfomicrobium baculatum DSM 4028
           RepID=C7LP91_DESBD
          Length = 245

 Score =  259 bits (663), Expect = 7e-68,   Method: Composition-based stats.
 Identities = 96/239 (40%), Positives = 141/239 (58%), Gaps = 12/239 (5%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           + +L++DE L+AV+KP+G LVHR+      +  ++Q +RDQ+GQ ++  HRLDRPTSG++
Sbjct: 9   IPVLHRDEHLIAVHKPAGLLVHRNA-HAGREPFLLQILRDQLGQRLYPVHRLDRPTSGLM 67

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKG 121
           +M LS +A   LA QF   ++ K Y A+ RG++  + ++D  L  E   +          
Sbjct: 68  IMALSPQAAHALALQFASQEVHKTYLAVTRGFVPPQGLIDDALKSESGSL---------- 117

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
            Q A T +  LAT E+P   G  PT RY +V + P+TGR HQ+RRH AH+RHP+IGD   
Sbjct: 118 -QEARTEFTRLATAEIPHPVGPNPTARYSMVRVRPRTGRTHQIRRHFAHIRHPLIGDVLR 176

Query: 182 GDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWRGLL 240
           GD RQNR   +HFGL RL+L + +L+  HP    P+T+        +    Q GW   +
Sbjct: 177 GDGRQNRFFRDHFGLHRLLLASVELTFRHPEDTSPMTLTCPPARELLDLFGQLGWNAAI 235


>UniRef50_B0K860 Pseudouridine synthase n=11 Tax=Thermoanaerobacterales
           RepID=B0K860_THEP3
          Length = 285

 Score =  259 bits (662), Expect = 8e-68,   Method: Composition-based stats.
 Identities = 59/236 (25%), Positives = 111/236 (47%), Gaps = 27/236 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKV---VVMQTVRDQIGQHVFTAHRLDRPTS 58
           L+I Y+DE ++ VNKP+  +VH +   +   +   V        +   +   +RLDR TS
Sbjct: 74  LDICYEDEEILIVNKPANMVVHPTKRYQSGTLANGVAWYFKEKGLKALIRPVNRLDRGTS 133

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           G+++          L        + K Y A+V G +  E  +D P+  +     ++   E
Sbjct: 134 GLVVFAKRPFMQYYLQII---KPMTKLYFAVVEGKMEGEGRIDLPISRKPQSGIERMVSE 190

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
           +     A+T+Y+ + +           + R+ L++++ +TGR HQ+R HL+H+ HPI+GD
Sbjct: 191 E--GDRAITNYKVVKS-----------SKRFSLLKVKIETGRTHQIRVHLSHIGHPIVGD 237

Query: 179 SKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           + +G             ++R  LHA +L+  HP   + +++++ L       L  F
Sbjct: 238 TLYGSSDDY--------IKRQALHAYRLTFVHPLEEKSISVYSPLPQDIQNLLKLF 285


>UniRef50_Q1QTG8 Pseudouridine synthase n=2 Tax=Gammaproteobacteria
           RepID=Q1QTG8_CHRSD
          Length = 261

 Score =  259 bits (662), Expect = 8e-68,   Method: Composition-based stats.
 Identities = 114/258 (44%), Positives = 148/258 (57%), Gaps = 7/258 (2%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           L +LYQDE +VAV KPSG LVHRS + RD +V  +QT+R+Q+G+HV+  HRLDRPTSG+L
Sbjct: 5   LPVLYQDERMVAVQKPSGMLVHRSPIARDARVFALQTLRNQLGRHVYPVHRLDRPTSGLL 64

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKG 121
           L  L  E  + L ++F  H++ KRY A+VRG   E+ +LDY L EE          E   
Sbjct: 65  LFALDPEMAQALGEEFTAHRVHKRYLAVVRGVGPEQDLLDYGLREEDGSRPKAEMPE--- 121

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
              A T  R L +VE+PV   RYP  RY L+E  P TGR+HQ+RRHLA   +PIIGD+KH
Sbjct: 122 -LEAWTAVRRLDSVELPVRIDRYPQVRYSLMEARPWTGRRHQIRRHLARRGYPIIGDAKH 180

Query: 182 GDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWRGLLP 241
           G    NR   E     RL+L A  +++ HP     L + A L D      ++FGW+G  P
Sbjct: 181 GKGAHNRFFRERLDSPRLLLAAVGMTVWHPEQARTLQLDAPLADDMQALFARFGWQGHAP 240

Query: 242 ENE---RVEFSAPSGQDG 256
                   E  A     G
Sbjct: 241 AARVAWHAERPAALLSPG 258


>UniRef50_Q03WF6 Pseudouridine synthase n=9 Tax=Firmicutes RepID=Q03WF6_LEUMM
          Length = 312

 Score =  259 bits (662), Expect = 9e-68,   Method: Composition-based stats.
 Identities = 68/228 (29%), Positives = 113/228 (49%), Gaps = 23/228 (10%)

Query: 13  AVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ-----HVFTAHRLDRPTSGVLLMGLSS 67
            VNKP G +VH +       +V        +            HR+DR TSG+L++  + 
Sbjct: 90  VVNKPQGMVVHPAAGHSSGTLVNALLHHSPLSTINGEFRPGIVHRIDRDTSGLLMVAKND 149

Query: 68  EAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADKFAREDKGPQPAV 126
           +A R L++Q + H+ Q+ Y+A+VRG   E+   ++ P+     KI  K     +G + AV
Sbjct: 150 KAHRSLSEQLKSHKNQRVYYALVRGEFTEDSGTIEAPIGRH--KIDRKKQAVIEGGREAV 207

Query: 127 THYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHGDLRQ 186
           TH+R L                Y L+++  +TGR HQ+R H++++ HP++GD  +G  ++
Sbjct: 208 THFRVLKRY-----------VGYTLLKVSLETGRTHQIRVHMSYIGHPVVGDPVYGTAQK 256

Query: 187 NRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
                +   L   +LHA  L+L  P TG+ L+  + L D +  ALS  
Sbjct: 257 ----LDGTQLNGQLLHAKTLTLEQPTTGDELSFDSPLPDYFQFALSTL 300


>UniRef50_Q9KQH0 Ribosomal large subunit pseudouridine synthase C n=59
           Tax=Proteobacteria RepID=RLUC_VIBCH
          Length = 315

 Score =  258 bits (661), Expect = 1e-67,   Method: Composition-based stats.
 Identities = 78/232 (33%), Positives = 120/232 (51%), Gaps = 17/232 (7%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLM 63
           I+Y+D+ L+ +NKPSG  VH         +  ++ +R Q  + +   HR+DR TSG+LL+
Sbjct: 97  IVYEDDHLLILNKPSGTAVHGGSGLHFGAIEALRALRPQ-ARFLELVHRIDRDTSGILLV 155

Query: 64  GLSSEAGRLLAQQFEQHQIQKRYHAIVRG-WLMEEAVLDYPLVEELDKIADKFAREDKGP 122
                A R L  QF +  +QK Y+A+V G W  E  V++ PL++          R +   
Sbjct: 156 AKKRSALRHLQAQFREKTVQKYYYALVMGHWDAECKVVNAPLLKNEVNS---IVRVNPNG 212

Query: 123 QPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHG 182
           +P+ T +R L                  LV+  P TGR HQ+R H  ++ HPI  D ++G
Sbjct: 213 KPSETRFRILEKF-----------AEATLVQASPVTGRTHQIRVHTQYMGHPIAWDDRYG 261

Query: 183 DLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           D R +   A  FG++RL LHA+ +   HP + + L IHA L+    QAL++ 
Sbjct: 262 DRRFDAYTA-QFGIERLFLHAANIQFVHPASEKKLEIHAPLEAHLEQALTKM 312


>UniRef50_Q4FN11 Pseudouridine synthase n=4 Tax=Bacteria RepID=Q4FN11_PELUB
          Length = 326

 Score =  258 bits (660), Expect = 1e-67,   Method: Composition-based stats.
 Identities = 64/250 (25%), Positives = 112/250 (44%), Gaps = 27/250 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIGQ-----HVFTAHRLD 54
           L+I+Y+D+ L+ +NKP+G ++H    + DE +V  +M   +D +            HR+D
Sbjct: 82  LQIVYEDDDLLIINKPAGIIMHPGAGNYDETIVNALMHYNKDSLSTIGDELRPGIVHRID 141

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIAD 113
           + TSG++++  ++E    L+ QF +H I + Y  ++ G L      +D  +     K   
Sbjct: 142 KDTSGLIVIAKNNETHENLSHQFSEHTITRVYQLLIWGKLRPSSGKIDTFITR-SSKNRQ 200

Query: 114 KFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
                +   + A+T+Y+ +   E         T    LVE   +TGR HQ+R H+ H+ +
Sbjct: 201 MMEVSNSKGKRAITNYKTIEIFEND------KTPTLSLVECRLETGRTHQIRVHMTHMGN 254

Query: 174 PIIGDSKHGDLRQNRSGAEH---------FGLQRLMLHASQLSLTHPFTGEPLTIHAGLD 224
            I+GD   G  ++     ++         + L R  LHA  L   HP T E +   + L 
Sbjct: 255 SIMGD---GKYKKKYKKLKNIDTNLENLIYKLDRQFLHAQTLGFIHPRTNEEMVFTSILP 311

Query: 225 DTWMQALSQF 234
                 L   
Sbjct: 312 QELENILVLL 321


>UniRef50_D1Y3Y9 Pseudouridine synthase n=1 Tax=Pyramidobacter piscolens W5455
           RepID=D1Y3Y9_9BACT
          Length = 345

 Score =  258 bits (660), Expect = 1e-67,   Method: Composition-based stats.
 Identities = 69/238 (28%), Positives = 109/238 (45%), Gaps = 24/238 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVR-DQIGQ-----HVFTAHRLDR 55
            +++Y+D+ ++ VNKP+G +VH      D  +V     R  +IG+          HRLD 
Sbjct: 116 FDVVYEDDDVIVVNKPAGVVVHPGAGRPDGTLVNGLMFRYPEIGRIGDSVRPGIVHRLDV 175

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADK 114
            TSG++++  S  A R L + F+ H++ K Y  +  G L   E  +D P+  +       
Sbjct: 176 GTSGLMVVARSDAAFRGLTEAFQAHEVLKEYLGLGVGALKAPEGTVDAPIGRDPRNRLKM 235

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
               D   + AVT Y+ L T             R  L+ +   TGR HQ+R H+  L   
Sbjct: 236 CVSWD--GRDAVTDYKVLWT-----------RARCNLIRVRLHTGRTHQIRVHMRALGCS 282

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALS 232
           + GD+ +G     +  A+H    R+ LH+ +L   HP +GE L   A L    + AL 
Sbjct: 283 LDGDTLYGP----KDPAQHILKDRVFLHSWRLGFRHPVSGERLEFRAPLPPELIAALR 336


>UniRef50_C0QAZ3 RluD1 n=1 Tax=Desulfobacterium autotrophicum HRM2
           RepID=C0QAZ3_DESAH
          Length = 313

 Score =  258 bits (659), Expect = 2e-67,   Method: Composition-based stats.
 Identities = 68/248 (27%), Positives = 116/248 (46%), Gaps = 27/248 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIGQHV------FTAHRL 53
           L+ L++D+W+V VNKP+G +VH    +    ++  ++         H          HRL
Sbjct: 81  LDFLHEDQWIVVVNKPAGMVVHPGAGNSSGTLLNALLHHFPSLTDTHCDPPLRGGIVHRL 140

Query: 54  DRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIA 112
           D+ TSG +++  S +A   L ++F   +++KRY A+  G + E +  +  P+        
Sbjct: 141 DKDTSGTIVVAKSKKAYEFLQKEFRFRRVEKRYIALATGIITETQGRITLPIGRHPIH-R 199

Query: 113 DKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLR 172
            + A   +  +PA T +R L  +             + L+++  KTGR HQ+R H   L 
Sbjct: 200 KRMAVNTERARPAETLWRVLGQM-----------AGHTLLDVGLKTGRTHQIRVHFRALG 248

Query: 173 HPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALS 232
           HP+ GD  +G       G +     R MLHA  L   HP++G+ +   A L +  ++ L 
Sbjct: 249 HPLAGDRVYG-----FRGKQSARAPRQMLHAGTLGFRHPWSGKRVEFTAPLPEDMVEVLE 303

Query: 233 QFGWRGLL 240
           +   RG L
Sbjct: 304 RLN-RGPL 310


>UniRef50_D0J9U5 Pseudouridine synthase n=2 Tax=Blattabacterium RepID=D0J9U5_BLASP
          Length = 344

 Score =  258 bits (659), Expect = 2e-67,   Method: Composition-based stats.
 Identities = 59/250 (23%), Positives = 106/250 (42%), Gaps = 29/250 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVV---MQTVRDQIGQHVFTAHRLDRPTS 58
           L ILY+DE ++ +NK +G +VH  + +    ++         +     +   HR+D+ T+
Sbjct: 87  LNILYEDEDILVINKAAGMVVHPGFGNEKGTLIHGIKYHFKNNHQLYRLGLVHRIDKDTT 146

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADK--F 115
           G+L++  +  A + L QQF    IQ++Y A+V G +  +E  +   +  + +       F
Sbjct: 147 GLLVLAKNEYAQKYLFQQFISKTIQRKYLALVWGNIQKQEGTISGFIGRDPNNRKRMTLF 206

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
            R     + +VTHY+ L   +               V    +TG+ HQ+R H  +L HP+
Sbjct: 207 QRNFYRSRYSVTHYKVLERFKY-----------LTYVSCNLETGKTHQIRVHFKYLGHPL 255

Query: 176 IGDSKHGDLR-----------QNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLD 224
             DS +G  +            +        L+R  LHA  LS  HP           + 
Sbjct: 256 FNDSTYGGDKIFMKKYLSKKSIDFFKDSLNLLKRQALHAGSLSFIHP-KNRKCHFTCSIP 314

Query: 225 DTWMQALSQF 234
           + + + L + 
Sbjct: 315 EDFKKVLQKL 324


>UniRef50_Q89AH2 Ribosomal large subunit pseudouridine synthase C n=5 Tax=Buchnera
           aphidicola RepID=RLUC_BUCBP
          Length = 315

 Score =  257 bits (658), Expect = 2e-67,   Method: Composition-based stats.
 Identities = 68/232 (29%), Positives = 113/232 (48%), Gaps = 13/232 (5%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLM 63
           ILY+D + + +NKPSG  VH         +  ++ +R    +++   HRLDR TSGVL++
Sbjct: 95  ILYEDNYFLILNKPSGMSVHSGSGINYGMIENLRILRPY-NRYLDLVHRLDRDTSGVLII 153

Query: 64  GLSSEAGRLLAQQFEQHQIQKRYHAIVRG-WLMEEAVLDYPLVEELDKIADKFAREDKGP 122
                  R L +Q  + +I+K+Y A+V G W      +  PL++   +      + D   
Sbjct: 154 AKKRSILRNLHEQLREKKIKKKYVALVHGVWPDILKSISKPLLKTSSRKNKNIVKIDPKG 213

Query: 123 QPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHG 182
           + ++TH+                 T+  L+ + P TGR HQ+R HL HL +PI+ D+K+G
Sbjct: 214 KESITHFNIKKKY-----------TKNTLISITPITGRTHQIRVHLLHLNYPIVLDAKYG 262

Query: 183 DLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
             + +      F + RL+LHA  ++  HP   + + I A LD  +   L   
Sbjct: 263 IKKLDYFIKNKFNINRLLLHAESINFFHPKRKKNILITAPLDYVFKTVLKNL 314


>UniRef50_C7LWM1 Pseudouridine synthase, RluA family n=1 Tax=Desulfomicrobium
           baculatum DSM 4028 RepID=C7LWM1_DESBD
          Length = 526

 Score =  257 bits (657), Expect = 3e-67,   Method: Composition-based stats.
 Identities = 69/238 (28%), Positives = 104/238 (43%), Gaps = 21/238 (8%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVV-----MQTVRDQIGQHVFTAHRLDRP 56
           L + + DE LV VNK     VH +    +  +V         +  Q G+     HRLD+ 
Sbjct: 82  LNVFFADEDLVVVNKTPAMTVHPAPSVAEPTLVHRVAHHFPALLSQSGERPGIVHRLDKD 141

Query: 57  TSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFA 116
           TSG++++ LS  A   L Q F   ++ K Y A+V G       +   L      I  + A
Sbjct: 142 TSGLIVLALSESARLSLTQAFASREVYKEYLALVAGVPDSSGTVSLALGRHP-SIKTRMA 200

Query: 117 REDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPII 176
             ++G + A T +  L +     A          LV +   TGR HQ+R H+A L HP++
Sbjct: 201 VVERGGRAAETRFELLWSAADRSA---------SLVRVRIMTGRTHQIRVHMAALGHPLL 251

Query: 177 GDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           GD+ + D +            R MLHA QL   HP + E +   A   D ++Q L + 
Sbjct: 252 GDAVYADKQTAARA------PRQMLHAWQLRFEHPRSFESMEFCAPPPDDFLQVLREL 303


>UniRef50_C6J6E3 Pseudouridine synthase n=2 Tax=Bacillales RepID=C6J6E3_9BACL
          Length = 321

 Score =  257 bits (657), Expect = 3e-67,   Method: Composition-based stats.
 Identities = 63/241 (26%), Positives = 106/241 (43%), Gaps = 25/241 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKV---VVMQTVRDQIGQHVFTAHRLDRPTS 58
            +I+Y+DE L+ VNK +G +VH +       +   VV               HRLD+ TS
Sbjct: 85  FDIVYEDEALLIVNKAAGLIVHPTHGHYTGTLANGVVYYWQEKGEKFRFRPVHRLDQETS 144

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADKFAR 117
           G++ +  ++   + +++Q    ++ K+Y A+V G     E  +D P+  +  +   +   
Sbjct: 145 GLIAIAKNAYVHQHISEQLIAGEVTKKYTALVHGCPAVPEGTIDGPIDRDPAEPHRRIVT 204

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
                 P++T+Y+                     VEL   TGR HQ+R H+  + HP+IG
Sbjct: 205 PS--GYPSLTYYKVAEAY-----------GDGARVELRLGTGRTHQIRVHMTSIGHPLIG 251

Query: 178 DSKHG--------DLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQ 229
           D  +G           + R       + R  LHAS+L   HP TGE LT  + L +  ++
Sbjct: 252 DKFYGMPGLAELPAPARERIARLDAAIGRQALHASELGFRHPLTGEALTFKSELPEDMLK 311

Query: 230 A 230
            
Sbjct: 312 L 312


>UniRef50_B6BTN1 Pseudouridine synthase n=2 Tax=Betaproteobacteria
           RepID=B6BTN1_9PROT
          Length = 346

 Score =  257 bits (657), Expect = 3e-67,   Method: Composition-based stats.
 Identities = 57/241 (23%), Positives = 101/241 (41%), Gaps = 22/241 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHV---FTAHRLDRPTS 58
           L+I+Y+D+ ++ +NKP   +VH    + +  ++      ++  + +      HRLD+ T+
Sbjct: 84  LDIVYEDDDILVLNKPYNLVVHPGSGNANGTLLNGLLYYNKDLEKLPRGGIVHRLDKDTT 143

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           G++++  + E+   L  Q +   + + Y AIV G + +  V+  P+     +   K A  
Sbjct: 144 GLMVVAKNEESQNNLISQLQSKSVYREYRAIVWGQIWQNKVIQKPIGRHP-RQRTKMAVT 202

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
               + A T    L                +  V    KTGR HQ+R H+     PI+GD
Sbjct: 203 KVNGKDAETKLEILERFNY-----------HTYVRCLLKTGRTHQIRVHMLDNNSPIVGD 251

Query: 179 SKHGDLRQNRSGAEHFGL-------QRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
             +G  +   +      L        R  LHA  L L HP T + +     L +   + L
Sbjct: 252 KDYGLKKIIPTKNMEMDLLKSIKNFDRQALHAIALGLIHPKTNKEMKWTIDLPEDMKELL 311

Query: 232 S 232
           S
Sbjct: 312 S 312


>UniRef50_B0RLZ1 Pseudouridine synthase n=13 Tax=Xanthomonadaceae RepID=B0RLZ1_XANCB
          Length = 258

 Score =  257 bits (657), Expect = 3e-67,   Method: Composition-based stats.
 Identities = 95/236 (40%), Positives = 137/236 (58%), Gaps = 11/236 (4%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           L+ILYQD  L  V+KP+G +VH S L R E   +   +R Q+G+ +F  HRLDR TSG L
Sbjct: 20  LQILYQDAVLAVVDKPAGLMVHDSKLARGEDDFLADRLRVQLGRPIFLVHRLDRATSGCL 79

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEA-VLDYPLVEELDKIADKFAREDK 120
           L+    +    L +     +++K Y AI RGW  EE  ++D+ L     K          
Sbjct: 80  LLAFDRDTASALGKALMAGEVEKDYLAICRGWPAEERFIVDHDLDGGPGKPIK------- 132

Query: 121 GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSK 180
             +PAVTH++ LAT E+ + +  + T+RY L+  +P+TGR  Q+RRHL HL H +IGD+ 
Sbjct: 133 --KPAVTHFQRLATGELEIPSTGFATSRYALLRCQPQTGRFRQIRRHLKHLSHHMIGDTS 190

Query: 181 HGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGW 236
           HGD R NRS     G+ R++LHA +L   HP  G  +++ A LD  + +A + FGW
Sbjct: 191 HGDGRHNRSFR-MLGIHRMLLHAERLGFPHPADGRRISVVAPLDVEFAKACALFGW 245


>UniRef50_C6XNC0 Pseudouridine synthase n=1 Tax=Hirschia baltica ATCC 49814
           RepID=C6XNC0_HIRBI
          Length = 369

 Score =  257 bits (657), Expect = 4e-67,   Method: Composition-based stats.
 Identities = 63/262 (24%), Positives = 107/262 (40%), Gaps = 38/262 (14%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIG-----QHVFTAHRLD 54
           L++L++DE L+ +NKP+G +VH +       +V  ++     Q+            HRLD
Sbjct: 98  LDVLFEDEHLIILNKPAGLVVHPAPGSTSGTLVNALLHHCAGQLPGIGGVARPGIVHRLD 157

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIAD 113
           + TSGV++   +  A   L+  F+ H +++ Y A+ RG        ++  +         
Sbjct: 158 KDTSGVMVAAKTEFAHTGLSSLFQAHFMERAYLAVTRGAPRPLLGKIETRIARSTTDRKK 217

Query: 114 KFARE------------------DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELE 155
                                  ++  + A+T+Y+ L       AT   P     L E  
Sbjct: 218 MAVVRESRLSASAEWHGESEEDYEQKGKHAITNYKVLEQFGRIDATSGLPA--ATLTECR 275

Query: 156 PKTGRKHQLRRHLAHLRHPIIGDSKHGDLRQNRSGAEHFG----------LQRLMLHASQ 205
            +TGR HQ+R H+AH+  P++GD  +G  R  ++                 +R  LHA+ 
Sbjct: 276 LETGRTHQIRVHMAHIGAPLLGDQTYGRYRGLKAHGSGPAFETATHACKEFKRQALHAAI 335

Query: 206 LSLTHPFTGEPLTIHAGLDDTW 227
           L   HP TGE L       +  
Sbjct: 336 LGFEHPVTGENLRFEVEPPEDM 357


>UniRef50_A8ZXZ8 Pseudouridine synthase n=1 Tax=Desulfococcus oleovorans Hxd3
           RepID=A8ZXZ8_DESOH
          Length = 329

 Score =  256 bits (656), Expect = 4e-67,   Method: Composition-based stats.
 Identities = 71/245 (28%), Positives = 108/245 (44%), Gaps = 27/245 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQI------GQHVFTAHRLDR 55
           L +L++D +L+ VNKP G +VH +       +V                      HRLDR
Sbjct: 82  LPLLFEDAFLLVVNKPPGLVVHPAPGHEGGTLVNRLLHHFPAIGTVGEPDRPGIVHRLDR 141

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADK 114
            TSG L++  ++ A + L+  F+  Q++K Y A+V G +     V+  P+     +   K
Sbjct: 142 NTSGALVVAKTAAAHQALSDMFKSRQVRKTYLALVYGQMKSTGGVVTLPIGRHSLE-RKK 200

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
            +      +PA T ++            R       L+ELE  TGR HQ+R H   L+ P
Sbjct: 201 MSVSSPQARPAETRWKV-----------RKAFVDASLLELEIHTGRTHQIRVHCTALQRP 249

Query: 175 IIGDSKH----GDLRQNRSGAEHFGL----QRLMLHASQLSLTHPFTGEPLTIHAGLDDT 226
           ++GD  +       RQ+ S    F L     R MLHA +L   HP TG P+   A L + 
Sbjct: 250 VVGDPTYPCKWTRKRQHFSSRASFELLNAAGRQMLHAWRLEFDHPVTGAPMCFTAPLFED 309

Query: 227 WMQAL 231
             + L
Sbjct: 310 IKEML 314


>UniRef50_D1U4S9 Pseudouridine synthase, RluA family n=1 Tax=Desulfovibrio
           aespoeensis Aspo-2 RepID=D1U4S9_9DELT
          Length = 596

 Score =  256 bits (656), Expect = 5e-67,   Method: Composition-based stats.
 Identities = 72/273 (26%), Positives = 112/273 (41%), Gaps = 32/273 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVR---------DQIGQHVFTAHR 52
           LE++++D  +  ++K +G   H +  +    +V     R             Q     HR
Sbjct: 99  LEVVFEDAHVAVIDKRAGLTTHPAPGEPGPTLVNHLLHRWPDVASDISGMDRQRPGIVHR 158

Query: 53  LDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKI 111
           LD+ TSG++++ L+      LA  F   +++K Y A+V G   +    +D P+     + 
Sbjct: 159 LDKDTSGLMVVALTEGDRLRLAADFAGRRVRKVYLAVVLGRPAQPAGTIDAPMGRHPSQ- 217

Query: 112 ADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHL 171
             + A   +G + AV+ YR L T          P     LV +   TGR HQ+R H+AH+
Sbjct: 218 KTRMAVVARGGREAVSDYRVLWT---------GPRGLASLVAVRIHTGRTHQIRVHMAHI 268

Query: 172 RHPIIGDSKHGDLR----QNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTW 227
            HP++GDS +G         R         R MLHA  LS  HP T E +T+       +
Sbjct: 269 GHPLLGDSAYGPRENVEWSRRPDRLAGLAPRQMLHAFHLSFRHPATCERVTLWRRPPADF 328

Query: 228 MQALSQFGWRGLLPENERVEFSAPSGQDGEISS 260
              L+    R  L            G  G   S
Sbjct: 329 CTLLAALP-RECL-------RVGIVGMPGSGKS 353


>UniRef50_UPI0001C42CC7 hypothetical protein BpOF4_01845 n=1 Tax=Bacillus pseudofirmus OF4
           RepID=UPI0001C42CC7
          Length = 322

 Score =  256 bits (655), Expect = 5e-67,   Method: Composition-based stats.
 Identities = 65/237 (27%), Positives = 105/237 (44%), Gaps = 25/237 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKV---VVMQTVRDQIGQHVFTAHRLDRPTS 58
           L+I Y+D+ L+ +NKP G     S       +   V+       I       +RLDR TS
Sbjct: 105 LDIHYEDDHLLVINKPQGMPTIPSREHPSRTLANAVMGYYESHHIPFTFHAVNRLDRDTS 164

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADKFAR 117
           G+L++     A   L++     ++++ Y A+  G++   E  +  P+      I ++   
Sbjct: 165 GLLVVAKHGLAHDQLSKGQRAGKLKRYYLALAEGFVQPREGTIHAPIKRRPSSIIERMVA 224

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
            D   Q A+THY+ +                Y  VE+  +TGR HQ+R H AHL HP++G
Sbjct: 225 AD--GQEAITHYKVI-----------NDNQAYSEVEINLETGRTHQIRVHFAHLGHPLLG 271

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           D  +G   +         L R  LH  ++ L HPFTG+ L   A L    ++   + 
Sbjct: 272 DDLYGGSIE--------LLARQALHCQRVELIHPFTGKHLHFSAPLPKDLIEVKDKL 320


>UniRef50_A6NQQ9 Pseudouridine synthase n=1 Tax=Bacteroides capillosus ATCC 29799
           RepID=A6NQQ9_9BACE
          Length = 300

 Score =  256 bits (655), Expect = 6e-67,   Method: Composition-based stats.
 Identities = 78/236 (33%), Positives = 111/236 (47%), Gaps = 24/236 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKV--VVMQTVRDQ-IGQHVFTAHRLDRPTS 58
           L+I+YQD+ ++ +NK  G  VH       + +   +M   R Q I       HRLDR TS
Sbjct: 84  LDIVYQDQDVLVLNKAPGVAVHPGPGHYSDTIGNFLMDYYRKQGILADFHPVHRLDRGTS 143

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADKFAR 117
           G+LL+ L   A  +L +Q      ++ Y A+  G       V+D P+      +  +  R
Sbjct: 144 GLLLVALHGHAQEVLKEQLHSPSFRRVYLAVCEGAPNPPSGVIDAPIGRLEGSVLARTVR 203

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
            D   Q AVTHYR L TV               LV LE +TGR HQ+R H+AHL HP+ G
Sbjct: 204 PD--GQRAVTHYRTLRTV-----------NDRALVRLELETGRTHQIRVHMAHLGHPLTG 250

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           D  +G         +   + R  LHA++LS THP TG+ +   A L       + +
Sbjct: 251 DFLYGT-------EDQSLIPRPALHAAELSFTHPITGKTMAFTAPLPQDMAALVPE 299


>UniRef50_C8WW59 Pseudouridine synthase n=2 Tax=Alicyclobacillus acidocaldarius
           RepID=C8WW59_ALIAD
          Length = 314

 Score =  256 bits (655), Expect = 6e-67,   Method: Composition-based stats.
 Identities = 63/238 (26%), Positives = 98/238 (41%), Gaps = 28/238 (11%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRD------QIGQHVFTAHRLDRPT 57
           + Y+D+ ++ V+KP G +VH         +V     R                HR+D+ T
Sbjct: 91  VAYEDDDVIVVDKPRGVVVHPGAGHMRGTLVNGLLARGTPLCTLAGALRPGVVHRIDKDT 150

Query: 58  SGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADKFA 116
           SG+++   S  A R L + F  H +++ Y AI  G +   E  +D P+  +         
Sbjct: 151 SGLVVFAKSDRAYRALVEAFRAHDVEREYVAIAHGRMPHREGTIDMPIARDPADRQRMAV 210

Query: 117 REDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPII 176
           R  +G + AVTH+  L +             +Y  + L  +TGR HQ+R HLA + HPI 
Sbjct: 211 R--QGGKRAVTHFEVLESF-----------AKYSYLRLRLETGRTHQIRVHLAAIGHPIA 257

Query: 177 GDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           GD  +G             +    LHA  L  THP  G  L   + +     + L   
Sbjct: 258 GDPVYGPRH-------TLPIDGQALHARTLGFTHP-DGRRLRFESAVPSDMARLLDGL 307


>UniRef50_A6GP31 Pseudouridine synthase n=1 Tax=Limnobacter sp. MED105
           RepID=A6GP31_9BURK
          Length = 335

 Score =  256 bits (654), Expect = 7e-67,   Method: Composition-based stats.
 Identities = 69/236 (29%), Positives = 113/236 (47%), Gaps = 9/236 (3%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           L IL++DE L+ VNKPSG  VH         +  ++ +R +  Q +   HR+DR TSG+L
Sbjct: 104 LPILFEDEHLLVVNKPSGMAVHGGSGSSFGLIECIRALRAETHQDLELVHRIDRETSGIL 163

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRG-WLMEEAVLDYPLVEELDKIADKFAREDK 120
           ++     A R L +Q      +K Y  +V G W      +D PL++      +     D+
Sbjct: 164 IISKKRSALRKLQEQLRARSWKKYYKTLVLGHWPEALRQVDLPLLKTQSSEKEARVFVDE 223

Query: 121 GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSK 180
               A T ++ +   +   ++       + L++ +  TGR HQ+R H +  + PI GD +
Sbjct: 224 SGDKACTKFKVIQCYKSSYSS-------FTLIQAQILTGRTHQIRVHTSANKFPIAGDDR 276

Query: 181 HGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGW 236
           +G+   N+  A   GL+R+ LHA++L L HP T E + + A L       L     
Sbjct: 277 YGNFEMNKQLARQ-GLKRMFLHAARLQLVHPATNETIVLEAPLAPELDGFLKSLQA 331


>UniRef50_C8P3R0 Pseudouridine synthase n=1 Tax=Erysipelothrix rhusiopathiae ATCC
           19414 RepID=C8P3R0_ERYRH
          Length = 308

 Score =  255 bits (653), Expect = 9e-67,   Method: Composition-based stats.
 Identities = 66/241 (27%), Positives = 115/241 (47%), Gaps = 27/241 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTV------RDQIGQ-HVFTAHRLD 54
           L+I+Y+D+ ++ VNKP G +VH S    ++  +V   +       D  G+      HR+D
Sbjct: 83  LDIVYEDDAILVVNKPKGLIVHPSPSTLNQPTLVHGLLAHTTQLSDLNGELRPGIVHRID 142

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIAD 113
           + T+G+L++  ++EA  +L +  +Q  I + Y AIV      + A +D P+  +  K   
Sbjct: 143 KDTTGLLVVAKTNEAHEILVEDLKQRLISREYVAIVHHQFKHQSATVDAPIGRDP-KNRQ 201

Query: 114 KFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
           + A  D+  + AVTH+                   + ++  +  TGR HQ+R H  +++H
Sbjct: 202 RMAVTDQNSKQAVTHFYLAERF-----------NDFSVLRCKLDTGRTHQIRVHAQYIKH 250

Query: 174 PIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           PI+GD  +       S    +      LHA +L+LTHP + E +T  A L  T    + +
Sbjct: 251 PIVGDQTY-------SYKNTWETNGQCLHAQKLTLTHPVSKEVMTFEAELPQTMKDVIEE 303

Query: 234 F 234
            
Sbjct: 304 I 304


>UniRef50_A3RGY8 Pseudouridine synthase n=1 Tax=uncultured bacterium
           RepID=A3RGY8_9BACT
          Length = 353

 Score =  255 bits (653), Expect = 9e-67,   Method: Composition-based stats.
 Identities = 58/241 (24%), Positives = 102/241 (42%), Gaps = 14/241 (5%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG---QHVFTAHRLDRPTS 58
           LE++++D+ ++ +NKP   +VH +       ++                   HRLD  TS
Sbjct: 110 LEVIFEDDAILVLNKPPKLVVHPAAGHWSGTLLNGLLAYAPTLIDVPRAGIVHRLDADTS 169

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           G++++  +  A   L +Q +   + + Y A+V G   +  V+D  +  +           
Sbjct: 170 GLMVVAKTLAAQTDLVRQLQSRTVTREYWALVLGVPSQRGVIDAAIGRDPRNPLRFKVST 229

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
            +  +PA THY  L +        +        +    +TGR HQ+R HL H+ HP+IGD
Sbjct: 230 TEAAKPARTHYATLDS-------TKNAGADISWLACRLETGRTHQIRVHLEHVGHPLIGD 282

Query: 179 SKHGDLRQNR--SGAEHFGLQRLMLHASQLSLTHPFTGEPLT-IHAGLDDTWMQALSQFG 235
             +      R    A      R  LHA +L+L HP + + L   H+       Q + + G
Sbjct: 283 PVYRRRLPPRGEPAARWKEFDRQALHACRLALDHPVSRQRLNWFHSP-AADLAQLMHELG 341

Query: 236 W 236
           +
Sbjct: 342 F 342


>UniRef50_Q2NIN6 Pseudouridine synthase n=4 Tax=Candidatus Phytoplasma
           RepID=Q2NIN6_AYWBP
          Length = 306

 Score =  255 bits (653), Expect = 1e-66,   Method: Composition-based stats.
 Identities = 65/238 (27%), Positives = 110/238 (46%), Gaps = 25/238 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVV-----MQTVRDQIGQHVFTAHRLDRP 56
           L+I+Y+D +L  +NKP+  +VH S   +   +V        T+     Q     HRLD+ 
Sbjct: 82  LDIIYEDPYLAVINKPANLVVHPSLSFQKTTLVNGLLHQFNTLSHIDTQRPGIVHRLDKN 141

Query: 57  TSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFA 116
           T+G+L++  +++    L   F+Q +I K Y A++ G+L ++ ++  P+            
Sbjct: 142 TTGLLIVAKTNDVSDKLQIAFQQRKITKIYWALIEGFLEDKGIIKLPIGRNNHNRLKMQV 201

Query: 117 REDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPII 176
             D   + AVTH++ L              + + L+E   +TGR HQLR H + L+HPI+
Sbjct: 202 MPD--GKTAVTHFKTLQRF-----------SHFSLMECNLETGRTHQLRAHFSFLKHPIV 248

Query: 177 GDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           GD  +         + H       LH+  L   HP T + L + A L   + + L  F
Sbjct: 249 GDLLY-------DSSHHITPLGQFLHSKILKFNHPITNQNLILEAPLPTNFEKLLKTF 299


>UniRef50_A5ZUU7 Pseudouridine synthase n=1 Tax=Ruminococcus obeum ATCC 29174
           RepID=A5ZUU7_9FIRM
          Length = 293

 Score =  255 bits (653), Expect = 1e-66,   Method: Composition-based stats.
 Identities = 60/233 (25%), Positives = 105/233 (45%), Gaps = 23/233 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKV---VVMQTVRDQIGQHVFTAHRLDRPTS 58
           + +LY+DE ++ VNKP+   VH S  +    +   V                +RLDR TS
Sbjct: 81  IPVLYEDEDILVVNKPADMPVHPSLGNYTNTLANGVAAYLETKGESCPFRCINRLDRDTS 140

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           G L++  ++ +  +L+ Q    QI + Y A+V G   +   +  P+    D + ++    
Sbjct: 141 GALILAKNALSAAILSVQMRNRQISRTYLAVVEGIPRQSGTISAPISRAADSVIERRIDF 200

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
           + G + A+THY+ L                + L+E+  +TGR HQ+R H+ ++ HP+  D
Sbjct: 201 ENG-ESAITHYQLLEV-----------KNNHSLLEIHLETGRTHQIRVHMGYIGHPLPAD 248

Query: 179 SKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
             +  +            +R  LH+ QL   HP TG P+ + A + +    A 
Sbjct: 249 YLYNPVYDT--------FKRQPLHSLQLKFCHPITGTPMCLMAPVPEDMSNAF 293


>UniRef50_C4XFS9 Pseudouridine synthase n=2 Tax=Mycoplasma RepID=C4XFS9_MYCFE
          Length = 315

 Score =  255 bits (652), Expect = 1e-66,   Method: Composition-based stats.
 Identities = 61/234 (26%), Positives = 111/234 (47%), Gaps = 26/234 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIGQ-----HVFTAHRLD 54
           L+I Y+D+ LV +NKPS  +VH S    ++ +V  ++   ++ +            HR+D
Sbjct: 84  LDIKYEDDDLVIINKPSNLVVHPSPGHYNDTLVNGLLYHFKNNLSNENGLLRPGIVHRID 143

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAV-LDYPLVEELDKIAD 113
           + TSG+L++  +++    L    ++H+I++ Y AIVRG +      ++ P+    + +  
Sbjct: 144 KDTSGLLIIAKNNKMHNSLTDMLKRHEIERSYLAIVRGLIENPLTKINLPIAR--NTVDR 201

Query: 114 KFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
           K     K  + A+T    L    +             LV  E KTGR HQ+R HL++++H
Sbjct: 202 KMMSVHKEGKEAITFVHLLKHFYLDKEPM-------SLVRCELKTGRTHQIRVHLSYIKH 254

Query: 174 PIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTW 227
           P+ GD  +G      +           LHA +L   HP T + + ++A +   +
Sbjct: 255 PVYGDPTYGKSVDEFN---------QRLHAYKLKFIHPLTKKEICVYAPVPKEF 299


>UniRef50_B8CWB7 Pseudouridine synthase n=1 Tax=Halothermothrix orenii H 168
           RepID=B8CWB7_HALOH
          Length = 310

 Score =  255 bits (652), Expect = 1e-66,   Method: Composition-based stats.
 Identities = 67/237 (28%), Positives = 121/237 (51%), Gaps = 24/237 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIGQH-VFTAHRLDRPTS 58
           L+I+Y+D  L+ +NKP+  LVH + +++   +V  V+  +R+Q   + V   HRLDR T+
Sbjct: 93  LDIIYEDRHLLVINKPANMLVHPTPVEKSNTIVNGVLYHMRNQGNYNLVRPIHRLDRNTT 152

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADKFAR 117
           G+LL+  +  A   +  QF+ + I + Y A V G +  ++  ++ P+ +  D +  +   
Sbjct: 153 GLLLIAKNQYAHNYITHQFQNNNIHREYLAFVHGNVEFKKESINAPIGKTRDSLIKRKVD 212

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
              G + AVTH + +            P     L+ ++ +TGR HQ+R HL+HL HP++G
Sbjct: 213 HTLG-KRAVTHIKVVK-----------PGGLISLIRVKLETGRTHQIRVHLSHLGHPLLG 260

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           D+ +G         E   ++R  LH+ +++   PF  + +T  A L     +   Q 
Sbjct: 261 DTLYGG--------EDILIKRPALHSYKVTCCLPFKHKEVTFKAPLPVDMEKLKKQL 309


>UniRef50_C0QV86 Pseudouridine synthase n=2 Tax=Brachyspira RepID=C0QV86_BRAHW
          Length = 329

 Score =  255 bits (652), Expect = 1e-66,   Method: Composition-based stats.
 Identities = 67/237 (28%), Positives = 109/237 (45%), Gaps = 28/237 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQ------IGQHVFTAHRLDR 55
           L+ILY+D++L+ +NKP+G  VH S  +    +V     + +        +     HRLD+
Sbjct: 109 LDILYEDKYLLVINKPAGMSVHCSPSEMSGTLVNALLYKIKDFDFVGNKERAGIIHRLDK 168

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAV-LDYPLVEELDKIADK 114
            TSG++++G ++     + +QF+   I+K YHAIV G L +  + ++ P+          
Sbjct: 169 DTSGLMIIGKNANIVSSIQEQFKNRTIKKIYHAIVVGVLKDNYIEINLPIGRHHVYRKKM 228

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
             RED   + A+TH + L                + L+E+  KTGR HQ+R H ++   P
Sbjct: 229 TVRED--GKEALTHIKVLKRF-----------NSHTLIEINLKTGRTHQIRVHSSYKGFP 275

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
           + GD  +       SG        LML A ++   HP T E L       D +   L
Sbjct: 276 VAGDKIYSKSFSKYSG--------LMLVAKKIEFMHPITKELLDFEIDYPDYFTNFL 324


>UniRef50_Q3JQ55 Pseudouridine synthase n=170 Tax=cellular organisms
           RepID=Q3JQ55_BURP1
          Length = 477

 Score =  254 bits (651), Expect = 1e-66,   Method: Composition-based stats.
 Identities = 80/240 (33%), Positives = 119/240 (49%), Gaps = 19/240 (7%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
            EIL++D+ ++ +NKP+G  VH         +  M+  R    + +  AHRLDR TSG+L
Sbjct: 243 FEILFEDDAIIVLNKPAGVAVHGGSGVAFGVIEQMRHARPH-AKFLELAHRLDRETSGIL 301

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE----AVLDYPLVEELDKIADKFAR 117
           ++     A   L +Q  ++++ KRY A V G    +     V+  PL +      ++  R
Sbjct: 302 MLAKKRSALVGLHEQIRENRMDKRYFACVHGDWAADWGRRRVVKAPLFKYATPDGERRVR 361

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
             +   P+ T +  +                Y LVE E KTGR HQ+R HLAHL  PI+G
Sbjct: 362 VQEDGLPSHTVFNLVDRW-----------PDYALVEAELKTGRTHQIRVHLAHLGLPIVG 410

Query: 178 DSKHGDLRQNRSGAEH---FGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           D+K+GD   N++ A       ++R+ LHA +L L HP TGEPL   A L     Q + Q 
Sbjct: 411 DAKYGDFALNKALARANAVPSIKRMFLHAHRLRLAHPLTGEPLQFDAPLPAECRQFIDQL 470


>UniRef50_A5IBH6 Pseudouridine synthase n=6 Tax=Legionella RepID=A5IBH6_LEGPC
          Length = 321

 Score =  254 bits (651), Expect = 2e-66,   Method: Composition-based stats.
 Identities = 64/245 (26%), Positives = 114/245 (46%), Gaps = 22/245 (8%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVR---DQIGQHVFTAHRLDRPTS 58
           ++I+Y+D  ++ VNKP+G +VH    +++  +V          Q+       HRLD+ T+
Sbjct: 87  IQIIYEDSEVIVVNKPAGLVVHPGAGNKEHTLVNALLHHCPELQLLPRAGIIHRLDKDTT 146

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           G+L++  +  +   L +Q +  +I++ Y  +V G+++    +D        K   K A  
Sbjct: 147 GLLIVAKNLISHTSLIRQMQNREIKRHYLTLVHGYVISGGTIDTGFGRHP-KNRLKMAVT 205

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
           D G Q AVTHY      +            + L+ +   TGR HQ+R H+ ++ HP++GD
Sbjct: 206 DFGRQ-AVTHYNINKHYK-----------DFTLLNVSLMTGRTHQIRVHMNYINHPVVGD 253

Query: 179 SKHGDLRQNRSGAEHFGL------QRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALS 232
             +G   +    A+   L      +R  LHA  +S  HP     +T++A L D +   L+
Sbjct: 254 QLYGGRMKFPPNADEAILSVLKQFKRQALHACSISFCHPVKNTEITLNALLPDDFELLLN 313

Query: 233 QFGWR 237
                
Sbjct: 314 TLDQH 318


>UniRef50_C6CWL6 Pseudouridine synthase n=2 Tax=Paenibacillus RepID=C6CWL6_PAESJ
          Length = 316

 Score =  254 bits (651), Expect = 2e-66,   Method: Composition-based stats.
 Identities = 67/242 (27%), Positives = 109/242 (45%), Gaps = 18/242 (7%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQI-GQHVF--TAHRLDRPTS 58
           L I+++D++L+ VNKP+G +VH +       +        Q+ G+ V     HRLD  TS
Sbjct: 89  LSIVFEDDYLLVVNKPAGIIVHPTKGHYTNTLANGIVHHWQVRGERVRFRPVHRLDEDTS 148

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADKFAR 117
           G++++  +    + L++Q +   I K Y A V G     +  +  P+    +    +   
Sbjct: 149 GLVVIAKNPYIHQQLSEQLQAGTIMKIYCAYVYGTPSPADGTVGAPIDRNPEDPHVRIVT 208

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
            +    P+VTHY+  A          +   +   V L+ +TGR HQ+R H+ H+  P+IG
Sbjct: 209 PE--GYPSVTHYKTAAV---------FGGGQASKVRLKLETGRTHQIRVHMKHIGCPLIG 257

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWR 237
           D  +G L+  +         R  LHA  L LTHP T E     A L    +Q   +   R
Sbjct: 258 DGMYG-LQTGKVDEWETAAGRQALHAETLGLTHPMTKEWSEWTAALPPDLVQL--ELALR 314

Query: 238 GL 239
             
Sbjct: 315 EC 316


>UniRef50_D2R7T3 Pseudouridine synthase, RluA family n=1 Tax=Pirellula staleyi DSM
           6068 RepID=D2R7T3_9PLAN
          Length = 355

 Score =  254 bits (651), Expect = 2e-66,   Method: Composition-based stats.
 Identities = 77/247 (31%), Positives = 105/247 (42%), Gaps = 25/247 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQI------GQHVFTAHRLDR 55
           L+IL++DE L+AVNKP G +VH +       +        Q              HRLDR
Sbjct: 115 LDILFEDEHLIAVNKPPGMVVHPARGHWSGTLTSALAFHFQQLSTVGGQHRPGIVHRLDR 174

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEA-VLDYPLVEELDKIADK 114
            TSGV+++  +      LA QF      K Y AI  G    +  V+  P+          
Sbjct: 175 DTSGVIIVAKTDPVHFSLAAQFADRTTAKEYFAITAGVPDRDRDVVSQPIGIHPFHREKM 234

Query: 115 FAREDK-GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
             R      + A T +  L               ++  VE  PKTGR HQ+R HLAH+R 
Sbjct: 235 AIRPGHSTSRDAETMFHVLERF-----------AQHAAVECLPKTGRTHQIRVHLAHVRT 283

Query: 174 PIIGDSKHGDLRQN------RSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTW 227
           P++ D  +G   +       R G+    L R  LHA +LS+ HP TGE LTI A L    
Sbjct: 284 PVLCDKLYGGRAEITQGELVRDGSTEVVLNRQALHARKLSINHPKTGERLTIEAPLPADL 343

Query: 228 MQALSQF 234
            + L   
Sbjct: 344 QRVLDLL 350


>UniRef50_A7H6D3 Pseudouridine synthase n=6 Tax=Cystobacterineae RepID=A7H6D3_ANADF
          Length = 339

 Score =  254 bits (651), Expect = 2e-66,   Method: Composition-based stats.
 Identities = 80/260 (30%), Positives = 126/260 (48%), Gaps = 23/260 (8%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVR-------DQIGQHVFTAHRLDRP 56
           +L++D  ++AV+KP+G   H         +V M                    AHRLDR 
Sbjct: 87  VLHEDADVLAVDKPAGLAAHPGTGISGATLVEMARAHLGTPADLPPTEFKPSPAHRLDRD 146

Query: 57  TSGVLLMGLSSEAGRLLAQQFEQH-QIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADK 114
           TSGV+L+  + +    L + F     ++K Y A+V+G +  E   +D PL E       K
Sbjct: 147 TSGVVLVAKNRKTMVRLTELFTDGADVKKTYLALVKGKMPREAGTIDLPLAEHEQTARSK 206

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
            AR     Q A+T ++ ++ ++              L+ +  +TGR HQ+RRHL  + HP
Sbjct: 207 AAR-GVNLQEALTRWKVVSAMK-----------EASLLAVTIETGRTHQIRRHLEAVGHP 254

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           ++GD ++GD   NR+  + +GL+R+ LHA +L L HP TG PL + A L    ++ALS+ 
Sbjct: 255 VLGDRRYGDFPTNRAARQRWGLRRMFLHAWRLELPHPTTGAPLRLEAPLPGELLEALSRA 314

Query: 235 GWRGLLPENERVEFSAPSGQ 254
                 P       +AP G 
Sbjct: 315 NLSS--PAGTASGRAAPRGA 332


>UniRef50_Q7UHX8 Pseudouridine synthase n=1 Tax=Rhodopirellula baltica
           RepID=Q7UHX8_RHOBA
          Length = 334

 Score =  254 bits (650), Expect = 2e-66,   Method: Composition-based stats.
 Identities = 71/257 (27%), Positives = 106/257 (41%), Gaps = 39/257 (15%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQI------GQHVFTAHRLDR 55
           L+ILY+D+ LV +NKP+G +VH +  +    +      R Q              HRLDR
Sbjct: 79  LDILYEDDGLVVINKPAGMVVHPARGNWTGTLTSALAFRFQSLSDVGGPTRPGIVHRLDR 138

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAV-LDYPLVEELDKIADK 114
            TSGV+++  ++     LA Q+    +QK Y AI  G L  +   +   +     +   +
Sbjct: 139 DTSGVIVVAKNNAVHLNLAAQWHDRLVQKEYTAITFGRLDRDRDWIHASIGRHPYQRDKQ 198

Query: 115 FAREDK-GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
             RE     + A T Y  +               R   V++ PKTGR HQ+R HLAH+  
Sbjct: 199 AIREGHATSKTASTFYEVVER-----------HGRVTRVDVRPKTGRTHQIRVHLAHIGC 247

Query: 174 PIIGDSKHGDLRQNRSGA--------------------EHFGLQRLMLHASQLSLTHPFT 213
           PI+ D  +G   +                         E   L R  LHA  L+ T+P T
Sbjct: 248 PILCDRLYGGHSELSRSQIRRLAGTEVATPGVKPTPEGEEILLSRQALHAKALTFTNPQT 307

Query: 214 GEPLTIHAGLDDTWMQA 230
           G+ +T+ A L       
Sbjct: 308 GKEMTLTAPLPPDLQAV 324


>UniRef50_C0GNZ6 Pseudouridine synthase, RluA family n=1 Tax=Desulfonatronospira
           thiodismutans ASO3-1 RepID=C0GNZ6_9DELT
          Length = 535

 Score =  254 bits (650), Expect = 2e-66,   Method: Composition-based stats.
 Identities = 72/241 (29%), Positives = 117/241 (48%), Gaps = 22/241 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQI------GQHVFTAHRLDR 55
           L+I+Y D  +V +NKP+G  VH S  D    +V                Q     HRLD+
Sbjct: 83  LDIVYMDREMVVLNKPAGLSVHPSSSDPAPTLVHYLLYACPGLRLMTDRQRPGIVHRLDK 142

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADK 114
            T+G+++  L+ EA   LA QF   ++ K Y A+V G L  +E +++ PL  +    A  
Sbjct: 143 DTTGLMVAALNQEAKEDLAGQFAGRRVHKTYLALVCGALKQDEGIINVPLARDQQSRAR- 201

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
                +  + A T Y+ L          R P+  + LV+++  TGR HQ+R H +HL HP
Sbjct: 202 -VAPSREGRSARTAYKVLK---------RDPSGLWSLVQVQIFTGRTHQIRVHFSHLNHP 251

Query: 175 IIGDSKHGDLRQNRSGAEHFGL----QRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQA 230
           ++GD  +G    +R G +   L    +R +LH+S L + HP + + L   +     +++ 
Sbjct: 252 VLGDRIYGGTDWDRFGWKKRFLSRLAKRQLLHSSCLGIMHPVSRQWLEFISRPPRDFIRT 311

Query: 231 L 231
           L
Sbjct: 312 L 312


>UniRef50_A4WSV2 Pseudouridine synthase n=41 Tax=Alphaproteobacteria
           RepID=A4WSV2_RHOS5
          Length = 349

 Score =  254 bits (649), Expect = 2e-66,   Method: Composition-based stats.
 Identities = 66/257 (25%), Positives = 105/257 (40%), Gaps = 40/257 (15%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG-------QHVFTAHRLD 54
           L ++++D  L+ ++KP G +VH +       +V                 +     HR+D
Sbjct: 90  LSVVWEDADLIVIDKPVGMVVHPAPGQWTGTLVNALLHHCGASLSGIGGEKRPGIVHRID 149

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEA---------------- 98
           + TSG+L++  +  A + LA QFE H +++RY A+V G                      
Sbjct: 150 KDTSGLLVVAKTDRAHQGLAAQFEAHTVERRYLALVHGVPEPSDPRLRGIRGVSFEPGGV 209

Query: 99  -VLDYPLVEELDKIADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPK 157
             +   +         +    + G + AVT  R L     P A          LVE   +
Sbjct: 210 LRIATGIARHRTDRQRQAVTFE-GGRHAVTRARLLERFGTPPA--------AALVECRLE 260

Query: 158 TGRKHQLRRHLAHLRHPIIGDSKHGDLRQNRSGA-------EHFGLQRLMLHASQLSLTH 210
           TGR HQ+R H++H+ H +IGD  +G  R+  + A             R  LHA+ L   H
Sbjct: 261 TGRTHQIRVHMSHVGHGLIGDQTYGGRRKLSAKAVGAEAAQAAEAFPRQALHAATLGFCH 320

Query: 211 PFTGEPLTIHAGLDDTW 227
           P TGE L+  + L    
Sbjct: 321 PVTGEDLSFESPLPADM 337


>UniRef50_B2RIT5 Pseudouridine synthase n=80 Tax=root RepID=B2RIT5_PORG3
          Length = 365

 Score =  254 bits (649), Expect = 3e-66,   Method: Composition-based stats.
 Identities = 65/261 (24%), Positives = 107/261 (40%), Gaps = 33/261 (12%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVR-------DQIGQHVFTAHRLD 54
           L+I+Y+D+ L+ +NKP+G +VH    +    +V             D +   +   HR+D
Sbjct: 110 LDIVYEDDVLLVINKPAGLVVHPGHGNYTGTLVNALAYYLREDPEYDPMDPSLGLVHRID 169

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIAD 113
           + TSG+L++   +EA   L +QF      + Y A+V G        +   +  +L     
Sbjct: 170 KDTSGLLVVAKRAEAKSDLCKQFYYKTTHRSYRALVWGRFDYPIGTITGNIGRDLKDRLQ 229

Query: 114 KFAREDKG--PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHL 171
                  G   +PAVTHY+ L  +                +E   +TGR HQ+R H+ H+
Sbjct: 230 MAVFPPDGDIGKPAVTHYQVLEELAYV-----------SWIECRLETGRTHQIRAHMKHI 278

Query: 172 RHPIIGDSKHGD---LRQNRSGAEHFGL-------QRLMLHASQLSLTHPFTGEPLTIHA 221
            H +  D ++G    LR N +      +        R  LHA  L   HP TG  +   +
Sbjct: 279 GHTLFADERYGGDQILRGNNTANYRRFVQNCLAICPRQALHAKTLGFRHPVTGVEMQFDS 338

Query: 222 GLDDTWMQALSQFGWRGLLPE 242
            +       L +  WR  +  
Sbjct: 339 DIPADLTTLLER--WRTFIAC 357


>UniRef50_Q6MEC0 Pseudouridine synthase n=1 Tax=Candidatus Protochlamydia
           amoebophila UWE25 RepID=Q6MEC0_PARUW
          Length = 318

 Score =  253 bits (648), Expect = 3e-66,   Method: Composition-based stats.
 Identities = 60/244 (24%), Positives = 104/244 (42%), Gaps = 24/244 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ------HVFTAHRLDR 55
           L ILY+DE L+ +NKP+G +VH +  +     V       Q              HRLD+
Sbjct: 87  LSILYEDEHLLVINKPAGMVVHPAPGNWSGTFVNALLYYCQKLPLLPDTIRPGIVHRLDK 146

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKF 115
            TSG+L+   + E  + L + F   ++ K Y AI  G    +  +  P+      I  K 
Sbjct: 147 GTSGLLVAAKTLETQQKLIELFASRKVYKAYLAICIGRPA-DGEIQAPIGRHP--IHRKQ 203

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
                  +PA++  + L             + +   V++E  TGR HQ+R H+ +   PI
Sbjct: 204 MAVIPTGKPAISFCKTLGW-----------SDKLSFVQIEIATGRTHQIRVHMKYRGSPI 252

Query: 176 IGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFG 235
           +GD  +G +  N    +++ +   +LHA+ L   HP + E L          ++ + +  
Sbjct: 253 LGDPLYGQISLN----QYYSVPHQLLHAAVLRFQHPISLENLEFCTPPPPEMVRLIKKID 308

Query: 236 WRGL 239
            +  
Sbjct: 309 PKSP 312


>UniRef50_C5J6Q2 Pseudouridine synthase n=1 Tax=Mycoplasma conjunctivae HRC/581
           RepID=C5J6Q2_MYCCR
          Length = 306

 Score =  253 bits (648), Expect = 4e-66,   Method: Composition-based stats.
 Identities = 62/235 (26%), Positives = 110/235 (46%), Gaps = 26/235 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQT------VRDQIGQ-HVFTAHRLD 54
            EI+YQD  ++ +NKP   +VH    + D+ +V          + D  G+      HRLD
Sbjct: 82  FEIVYQDNDIIVINKPKNLVVHPGNGNWDKTLVNGLLHEFATNLSDVNGEIRPGIVHRLD 141

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAV-LDYPLVEELDKIAD 113
           + TSG+LL+  +++A + LA+Q E H+I+++Y AIV G +    + ++ P+  +      
Sbjct: 142 KDTSGLLLVAKNNQAHKYLAKQLENHEIERKYIAIVVGKIPHTKMRINLPIGRDNQNRTK 201

Query: 114 KFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
           K        + A+T+   + T         Y    + +V+   +TGR HQ+R HL+H+ +
Sbjct: 202 K-VVSSFNSKNAITNVELINTF-------VYKNEHFSIVKCILETGRTHQIRVHLSHIGY 253

Query: 174 PIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWM 228
           PI GD  +G    +             LHA +++  H   G  +     + D + 
Sbjct: 254 PIYGDPVYGKKIDDL---------GQRLHAYEITFKH-LDGRLMNFKTEMPDEFK 298


>UniRef50_Q8ZFU1 Ribosomal large subunit pseudouridine synthase C n=102
           Tax=Gammaproteobacteria RepID=RLUC_YERPE
          Length = 320

 Score =  253 bits (648), Expect = 4e-66,   Method: Composition-based stats.
 Identities = 75/232 (32%), Positives = 113/232 (48%), Gaps = 14/232 (6%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLM 63
           IL++D++L+ +NKPSG  VH         +  ++ +R +  + +   HRLDR TSGVLL+
Sbjct: 95  ILFEDDYLLVLNKPSGTAVHGGSGLSFGVIEGLRALRPE-ARFLELVHRLDRDTSGVLLV 153

Query: 64  GLSSEAGRLLAQQFEQHQIQKRYHAIVRG-WLMEEAVLDYPLVEELDKIADKFAREDKGP 122
                A R L +Q     +QK Y A+VRG W      +  PL++ + +  ++  +     
Sbjct: 154 AKKRSALRSLHEQLRLKSMQKDYLALVRGQWQSHCKAIQAPLLKNIMQSGERVVKVSSEG 213

Query: 123 QPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHG 182
           +P+ T ++     E              LV+  P TGR HQ+R H  H  HPI  D ++G
Sbjct: 214 KPSETRFKIEERFE-----------HATLVKASPVTGRTHQIRVHALHAGHPIAFDDRYG 262

Query: 183 DLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
             R+     +  GL RL LHA+ L   HP TGE + I A LD+     L   
Sbjct: 263 -YREFDQQLQGTGLHRLFLHAAALRFEHPNTGETMRIEAPLDNQLRHCLLAL 313


>UniRef50_C7H7W3 Ribosomal large subunit pseudouridine synthase D n=2
           Tax=Faecalibacterium prausnitzii RepID=C7H7W3_9FIRM
          Length = 314

 Score =  253 bits (647), Expect = 4e-66,   Method: Composition-based stats.
 Identities = 66/246 (26%), Positives = 103/246 (41%), Gaps = 27/246 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG-------QHVFTAHRLD 54
           L+I+Y+D  L+ VNKP G +VH +  + D  +V       +               HR+D
Sbjct: 80  LDIIYEDAHLLVVNKPKGMVVHPAPGNPDGTLVNALLWHCKGSLSGIGGEIRPGIVHRVD 139

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIAD 113
           + TSG+L++         L+QQ   H +++ Y+ IV G   + E  ++  L         
Sbjct: 140 KDTSGLLVVAKDDATHIGLSQQMAVHSVERAYNTIVYGGFAQDEGFVESNLGRSKTDRKK 199

Query: 114 KFAREDKGP--QPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHL 171
                   P  + A T Y+ L  +             + ++E   KTGR HQ+R H+A +
Sbjct: 200 MAVYPASEPHTKYAYTGYKVLERL-----------GEFTMLECRLKTGRTHQIRVHMASI 248

Query: 172 RHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
            HP+ GD  +G             L    LHA  L   HP TGE L   + L D + + L
Sbjct: 249 HHPVAGDPVYGPHNC------ITSLHGQCLHAKTLGFIHPITGEHLRFDSELPDYFTRFL 302

Query: 232 SQFGWR 237
           +    R
Sbjct: 303 TTLRQR 308


>UniRef50_C1A885 Pseudouridine synthase n=1 Tax=Gemmatimonas aurantiaca T-27
           RepID=C1A885_GEMAT
          Length = 329

 Score =  253 bits (647), Expect = 5e-66,   Method: Composition-based stats.
 Identities = 61/241 (25%), Positives = 104/241 (43%), Gaps = 22/241 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQI------GQHVFTAHRLDR 55
           L+++Y+DE L+ V+K +G +VH +  +    +V     R +              HRLD+
Sbjct: 83  LDVVYEDEHLLVVDKAAGMVVHPAPGNWTGTLVNALLGRGEPLAEGGGEDRAGLVHRLDK 142

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEA-VLDYPLVEELDKIADK 114
            TSG+L++  S  A R L+      Q+ +RY A+  G L EE   ++ P+  +       
Sbjct: 143 DTSGLLVVAKSDAAHRTLSSALAARQVTRRYAAVCWGHLAEERITVEKPIARDPRDRTRM 202

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
                +  + + T +  LA  +              L+     TGR HQ+R HLA   HP
Sbjct: 203 AIV--QSGKASRTDFTRLARFDSVD-----------LLRAHLHTGRTHQIRVHLASTGHP 249

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           ++GD  +               +R  LHA+ L   HP +G+ + + + L      +L+  
Sbjct: 250 VVGDDTY--GGGGGRRLALLPPRRHFLHAAWLRFRHPISGDLIDLRSPLPADLRTSLAAL 307

Query: 235 G 235
           G
Sbjct: 308 G 308


>UniRef50_C1CWT3 Pseudouridine synthase n=1 Tax=Deinococcus deserti VCD115
           RepID=C1CWT3_DEIDV
          Length = 321

 Score =  252 bits (646), Expect = 5e-66,   Method: Composition-based stats.
 Identities = 77/254 (30%), Positives = 117/254 (46%), Gaps = 29/254 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVR----------DQIGQHVFTAH 51
           L+++Y+D++L+AVNKP G + H +       +V     R           + G      H
Sbjct: 77  LDVIYEDDYLIAVNKPPGMVTHPAPGVLSGTLVNALLGRMPLPEQPDYDSEAGYRPGIVH 136

Query: 52  RLDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEA--VLDYPLVEELD 109
           RLD+ TSGV+++  +  A   LA  F+  + +K Y AI  G    +    ++ P+     
Sbjct: 137 RLDKDTSGVIVVAKTVGAHARLAAAFKDRETRKTYLAIAAGQWRADGPARVEAPIGRHPV 196

Query: 110 KIADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLA 169
           +   +       P+ A T +  LA    P   GR       LV  +P+TGR HQ+R HLA
Sbjct: 197 Q-RQRMTVGGANPREAQTLFTPLAA--HPDGHGR----TLALVRAQPRTGRTHQIRVHLA 249

Query: 170 HLRHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQ 229
           HL  PI+GD+ +G   +         + R  LHA  LS+ HP TG  L +HA   D  + 
Sbjct: 250 HLGSPILGDAVYGRSSET--------MLRHALHAHFLSVPHPGTGRLLHLHAPAPDDMLN 301

Query: 230 ALSQFGWRGLLPEN 243
           A    G  G +P +
Sbjct: 302 AWIALG--GAMPSD 313


>UniRef50_B7GLK3 Pseudouridine synthase n=11 Tax=Bacillaceae RepID=B7GLK3_ANOFW
          Length = 292

 Score =  252 bits (646), Expect = 6e-66,   Method: Composition-based stats.
 Identities = 68/234 (29%), Positives = 118/234 (50%), Gaps = 25/234 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKV---VVMQTVRDQIGQHVFTAHRLDRPTS 58
           L I+Y+D++++ +NKP       S       +   ++    + Q+   V    RLDR TS
Sbjct: 80  LAIVYEDDYVIVINKPPHMSTIPSREHPHGTLANALLHHYEQQQLQTTVHVVTRLDRDTS 139

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADKFAR 117
           G++L+        LL++Q +Q ++++RY A+  G++++    +D P+  + D I ++  R
Sbjct: 140 GLVLVAKHRHVHHLLSEQQKQGRVKRRYEAVCHGYVIQLVGTIDAPIGRKGDSIIEREVR 199

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
            D   Q AVTHY  L                   V ++ +TGR HQ+R H +H+ HP++G
Sbjct: 200 LD--GQRAVTHYEVLQQ-----------KNEMTHVSIQLETGRTHQIRVHFSHIGHPLVG 246

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
           D  +G LR++        + R  LH+ +L+  HPF  + +T HA L D   + L
Sbjct: 247 DDLYGGLREH--------IDRQALHSCELTFFHPFFEKTMTFHAPLPDDIARLL 292


>UniRef50_A5IZB6 Pseudouridine synthase n=4 Tax=Mycoplasma RepID=A5IZB6_MYCAP
          Length = 305

 Score =  252 bits (646), Expect = 6e-66,   Method: Composition-based stats.
 Identities = 65/234 (27%), Positives = 117/234 (50%), Gaps = 26/234 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIGQ-----HVFTAHRLD 54
           L+I Y+DE+L+ +NKPSG +VH +    ++ +V  +M   ++ +        +   HR+D
Sbjct: 76  LDIRYEDEYLLILNKPSGLVVHPAPGHLNDTLVNALMYHFKNNLSDANGLLRLGIVHRID 135

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAV-LDYPLVEELDKIAD 113
           + TSG+L++   +E    LA+  + HQI++ Y AI  G L  +   ++ P+  +      
Sbjct: 136 KDTSGLLIIAKDNETHNELAKMLKNHQIKRTYLAICEGILPNKTTKINLPIQRDTKN--R 193

Query: 114 KFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
           K     K  + +VT+   L +  +           Y LV+ E +TGR HQ+R HLA+++H
Sbjct: 194 KLMSIHKDGKSSVTYVHMLKSFYID-------NKPYSLVKCELETGRTHQIRVHLAYIKH 246

Query: 174 PIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTW 227
           P+ GDS +G      +           LHA +LS  HP   + + +++ +   +
Sbjct: 247 PVYGDSIYGKSVDEFN---------QRLHAYKLSFMHPVINKLIEVYSDIPKEF 291


>UniRef50_P44433 Ribosomal large subunit pseudouridine synthase C n=22
           Tax=Gammaproteobacteria RepID=RLUC_HAEIN
          Length = 322

 Score =  252 bits (644), Expect = 9e-66,   Method: Composition-based stats.
 Identities = 73/233 (31%), Positives = 109/233 (46%), Gaps = 14/233 (6%)

Query: 3   EILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLL 62
           +IL++D+ L+ +NKPSG  VH         +  ++ +R +  + +   HRLDR TSG+LL
Sbjct: 99  QILFEDDCLIILNKPSGIAVHGGSGLNFGVIEALRALRPE-ARFLELVHRLDRDTSGILL 157

Query: 63  MGLSSEAGRLLAQQFEQHQIQKRYHAIVRG-WLMEEAVLDYPLVEELDKIADKFAREDKG 121
           +     A R L +Q     +QK Y A+VRG W     V+   L++      ++  R  + 
Sbjct: 158 IAKKRSALRNLHEQLRVKTVQKDYLALVRGQWQSHIKVIQASLLKNELSSGERIVRVSEQ 217

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
            +P+ T +                     LV+  P TGR HQ+R H  +  HPI  D K+
Sbjct: 218 GKPSETRFSIEERY-----------INATLVKASPVTGRTHQIRVHTQYAGHPIALDDKY 266

Query: 182 GDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           GD   ++   E  GL RL LHA  +   HP  GE L  +A LD      L + 
Sbjct: 267 GDKDFDKQMNE-LGLNRLFLHAFSIRFEHPKNGETLRFNASLDHQMKAILQKL 318


>UniRef50_A9IIW7 Pseudouridine synthase n=5 Tax=Bordetella RepID=A9IIW7_BORPD
          Length = 324

 Score =  252 bits (644), Expect = 1e-65,   Method: Composition-based stats.
 Identities = 64/236 (27%), Positives = 96/236 (40%), Gaps = 17/236 (7%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHV---FTAHRLDRPTSGV 60
           ++ +    + V+KP+G + H    +    ++     R      V      HRLD+ TSG+
Sbjct: 101 VVAESPDWIVVDKPAGLVTHPGAGNWSGTLLNGLLHRYPELARVARAGIVHRLDKDTSGL 160

Query: 61  LLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDK 120
           +++  +  A   L +Q +   + + Y A+  GWL     +D P+  +             
Sbjct: 161 MVVARNELAQTHLVRQLQARSMGREYIALAHGWLPVAGKVDRPIGRDARVPVRMSVERPI 220

Query: 121 GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSK 180
            P+PA+THY  L         GR P      V    +TGR HQ+R HLA L HP++ D+ 
Sbjct: 221 APKPAITHYAPLRR-------GRAPDGPVTEVACRLETGRTHQIRVHLASLGHPLLADTL 273

Query: 181 HGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGW 236
           +G       G    G  R MLHA  L    P  G P    A   D   Q      W
Sbjct: 274 YG-------GRLTAGATRQMLHARALHFDDPGGGGPAAFRADPPDDMRQVQEALQW 322


>UniRef50_C1FEQ4 Predicted protein n=2 Tax=Micromonas RepID=C1FEQ4_9CHLO
          Length = 357

 Score =  251 bits (643), Expect = 1e-65,   Method: Composition-based stats.
 Identities = 67/261 (25%), Positives = 106/261 (40%), Gaps = 37/261 (14%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTV----RDQIG---------QHVF 48
           L+++++D+ LV VNKP G +VH S       +V         R   G           + 
Sbjct: 103 LDVVFEDDHLVVVNKPPGMVVHPSAGHAGGSLVNALLFHCNERSNRGDDASKMIDVPRLG 162

Query: 49  TAHRLDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEE 107
             HR+D+ TSG+L+M   + A   L  QF    +++RY AIV G    E   +D P+  +
Sbjct: 163 VVHRIDKGTSGLLVMAKDAAAQAGLQTQFANRSVRRRYLAIVLGTPARESGRIDAPIGRD 222

Query: 108 LDKIADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRH 167
                          + A++++   A         R       LVE + +TGR HQ+R H
Sbjct: 223 PADRLKMAIVRGATGRQAISNFGVRA---------RLVRGNASLVEWQLETGRTHQIRVH 273

Query: 168 LAHLRHPIIGD--------------SKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFT 213
              + HPI+GD               + G +    +        R MLHA  L   HP T
Sbjct: 274 AREMGHPIVGDEAYGGGGSAAAEFLRRDGAMSAAAAREIVAKCARPMLHARSLGFRHPVT 333

Query: 214 GEPLTIHAGLDDTWMQALSQF 234
           GE ++        ++ A ++ 
Sbjct: 334 GEEISFAVEPPPDFVDAFTEL 354


>UniRef50_UPI00016C3FBA ribosomal large subunit pseudouridine synthase n=1 Tax=Gemmata
           obscuriglobus UQM 2246 RepID=UPI00016C3FBA
          Length = 354

 Score =  251 bits (643), Expect = 1e-65,   Method: Composition-based stats.
 Identities = 71/256 (27%), Positives = 109/256 (42%), Gaps = 28/256 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQ--TVRDQIGQ-----HVFTAHRLD 54
           L+ILYQDEWL  VNKP+  +VH +  +    +V       R+ +            HRLD
Sbjct: 109 LDILYQDEWLALVNKPADMVVHPAKGNWSGTLVNALQWHFREHLSTGAGHLRAGIVHRLD 168

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEA-VLDYPLVEELDKIAD 113
           + TSGV+L+       R LA QFE  ++ K Y AI  G L  ++  ++  L         
Sbjct: 169 KDTSGVILVAKDDLTHRDLAMQFESRKVFKEYVAIAAGELERDSDYIEGALKMHPYDRLK 228

Query: 114 KFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
                D   + A+++Y  L                + LV+++P+TGR HQ+R HL H+  
Sbjct: 229 MIVSTDPDAKHALSYYEVLERFR-----------GFTLVKVQPRTGRTHQIRVHLLHVGC 277

Query: 174 PIIGDSKHGDLRQNR---------SGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLD 224
            ++ D  +G   Q +            +   L R  LHA +L   HP TG+ +   A L 
Sbjct: 278 AVLADKIYGGRAQVKLSEIAPGTPPAEDEVLLGRQALHAFRLRFQHPRTGQWIEAEAPLP 337

Query: 225 DTWMQALSQFGWRGLL 240
               + L        +
Sbjct: 338 PDMRRTLDALRQHRAI 353


>UniRef50_C9M5C8 Pseudouridine synthase n=1 Tax=Jonquetella anthropi E3_33 E1
           RepID=C9M5C8_9BACT
          Length = 276

 Score =  251 bits (642), Expect = 2e-65,   Method: Composition-based stats.
 Identities = 74/242 (30%), Positives = 112/242 (46%), Gaps = 23/242 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           L++LY+ + ++ +NKP+G L        D                    HRLDR TSGV+
Sbjct: 49  LDVLYRSDSVLVINKPAGLLSQPDTKGEDSVATRALGYASDPAFGAQLVHRLDRNTSGVM 108

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKG 121
           ++ L  +A R L   F++    K Y A+V G L     +D PL+++ DK   K  R    
Sbjct: 109 ILALDGQALRSLMVCFKERTANKTYLALVSGQLPPSGQIDAPLLKDPDK---KLVRVASN 165

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
            + AVT +R LAT             ++ L E+E  TGR HQ+R H+ H+ HPI+GD+K+
Sbjct: 166 GERAVTRFRRLAT-----------DGQFSLAEVEILTGRTHQIRVHMNHIGHPILGDAKY 214

Query: 182 GDLRQNRSGAEHFGLQRLMLHASQLSLTHP------FTGEPLTIHAGLDDTWMQALSQFG 235
           GD    +      G++R MLHA+ L +  P       +G      A L         + G
Sbjct: 215 GDFSA-KPQVRRLGIRRPMLHATCLVVNSPDDCLKEISGRR--FDAPLAADMASVCQKLG 271

Query: 236 WR 237
           + 
Sbjct: 272 FE 273


>UniRef50_B7HGW1 Pseudouridine synthase n=52 Tax=Bacillales RepID=B7HGW1_BACC4
          Length = 297

 Score =  251 bits (642), Expect = 2e-65,   Method: Composition-based stats.
 Identities = 66/236 (27%), Positives = 114/236 (48%), Gaps = 25/236 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKV---VVMQTVRDQIGQHVFTAHRLDRPTS 58
           L I+Y+D+ ++ +NK +      S       V   ++    +  +   V    RLDR TS
Sbjct: 82  LCIIYEDDAVLIINKEANMSTIPSREHPAGSVANALLSHYDKQHLASTVHIVTRLDRDTS 141

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADKFAR 117
           G++L+  +     LL++Q +Q  +++ Y AIV G ++E E ++D P+  + D I ++   
Sbjct: 142 GLMLIAKNRFVHHLLSKQHQQKAVKRTYEAIVHGKIVEREGMIDAPIGRKSDSIIERTVC 201

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
           ED   Q AVTH++ + +                 V LE +TGR HQ+R H+AH+ HP++G
Sbjct: 202 ED--GQRAVTHFKVIDSTYHK-----------THVALELETGRTHQIRVHMAHVGHPLLG 248

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           DS +G  R          ++R  LH+  L+  HP   + ++    L     + L  
Sbjct: 249 DSLYGGRRDE--------MKRQALHSKSLTFYHPILEKEMSFTIKLPSDMQEVLRH 296


>UniRef50_B8FTI5 Pseudouridine synthase n=2 Tax=Desulfitobacterium hafniense
           RepID=B8FTI5_DESHD
          Length = 302

 Score =  251 bits (642), Expect = 2e-65,   Method: Composition-based stats.
 Identities = 73/237 (30%), Positives = 110/237 (46%), Gaps = 25/237 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKV---VVMQTVRDQIGQHVFTAHRLDRPTS 58
           LEILY+D++ +A+NKP+G +VH +       +   VV   +     +     HR+DR TS
Sbjct: 83  LEILYEDDYFIAINKPAGQVVHPTPRYPRGTIGNAVVGYWLAKGEARPFRPIHRIDRNTS 142

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADKFAR 117
           GV+++G +  A + +A Q    +I K Y  IV G +ME+   +  P+    D    +   
Sbjct: 143 GVVVIGKNQFAHQQMAWQHAHGRIHKCYRGIVEGQVMEDQGTIKAPIALAPDSFIQRQIS 202

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
            +    PAVT Y+ L                  L+E   +TGR HQ+R H  HL HP++G
Sbjct: 203 PE--GSPAVTLYKVLERY-----------QDASLLEFILETGRTHQIRVHCQHLGHPLLG 249

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           D  +G             + R  LH+S     HP TGE  TI A L +   + L + 
Sbjct: 250 DDLYGG--------NLARINRQALHSSIYEFNHPLTGELTTIQAPLPEDLQRLLREL 298


>UniRef50_C0ZCK6 Pseudouridine synthase n=1 Tax=Brevibacillus brevis NBRC 100599
           RepID=C0ZCK6_BREBN
          Length = 302

 Score =  251 bits (642), Expect = 2e-65,   Method: Composition-based stats.
 Identities = 69/236 (29%), Positives = 108/236 (45%), Gaps = 25/236 (10%)

Query: 3   EILYQDEWLVAVNKPSGWLVHRSWLDRDEKV---VVMQTVRDQIGQHVFTAHRLDRPTSG 59
           EILY+D+ L+ VNKP G L+H +       +   V     R  +   V   HRLD+ TSG
Sbjct: 87  EILYEDDHLLIVNKPVGLLLHPTERYHHVTLDHLVSGHFFRTGLEAKVRHVHRLDQDTSG 146

Query: 60  VLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADKFARE 118
           V+L      A  LL +   +  I++ Y A V G + +E   ++ P+ ++ +    +  R 
Sbjct: 147 VVLYAKHPWASALLDEMLRERTIKRTYVAYVSGQMPKERGKINEPIGKDRNHGTRR--RV 204

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
                PA+THY+                     VE + +TGR HQ+R H +H+ HP++GD
Sbjct: 205 TPNGDPAITHYQVKERF-----------QTATKVECQLETGRTHQIRVHFSHIGHPLLGD 253

Query: 179 SKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
             +G  R+         ++R  LHA+ L   HPF GE + + A L         + 
Sbjct: 254 ELYGGKRE--------LIKRQALHAAVLKFEHPFGGEVIEVTAPLPLDLFHLEKKL 301


>UniRef50_A9B3Z2 Pseudouridine synthase n=1 Tax=Herpetosiphon aurantiacus ATCC 23779
           RepID=A9B3Z2_HERA2
          Length = 560

 Score =  251 bits (641), Expect = 2e-65,   Method: Composition-based stats.
 Identities = 92/255 (36%), Positives = 127/255 (49%), Gaps = 26/255 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAH-RLDRPTSGV 60
           +EILY+DE ++ +NKP+G   H    D     V  + +R Q+       H RLDR TSGV
Sbjct: 3   IEILYRDEQILVINKPTGVATHAPQGDLALTDV-ERALRAQLQLEYLAIHQRLDRDTSGV 61

Query: 61  LLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADKFARED 119
           +L  L   A   LA  F +H I+K Y A+V G  ++ + V+D  L    D +    +  D
Sbjct: 62  MLFALDPAANANLATAFAEHTIEKTYQALVYGVPIQTQGVIDAALAPAGDGMIQVASAHD 121

Query: 120 KGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDS 179
           +  Q A+THYR L +          P  R+ L+EL+PKTGR HQLR H   L HPI+GD 
Sbjct: 122 RRAQSAITHYRVLVS---------SPDQRFSLLELQPKTGRTHQLRVHCECLGHPIVGDP 172

Query: 180 KHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWRGL 239
            +   R            RLMLHAS+L  THP T +PL I A     + +       +GL
Sbjct: 173 LYDVAR---------AAPRLMLHASELRFTHPLTQQPLHIQAPTPALFTRV-----AQGL 218

Query: 240 LPENERVEFSAPSGQ 254
               +  E +A +G 
Sbjct: 219 PELQQSTELAALNGL 233


>UniRef50_D1CBT6 Pseudouridine synthase n=1 Tax=Thermobaculum terrenum ATCC BAA-798
           RepID=D1CBT6_THET1
          Length = 313

 Score =  251 bits (641), Expect = 2e-65,   Method: Composition-based stats.
 Identities = 68/238 (28%), Positives = 107/238 (44%), Gaps = 27/238 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVR-----DQIGQHVFTAHRLDRP 56
           L ++Y+D+ ++ ++KP+G +VH S    D  +V     R      Q        HRLD+ 
Sbjct: 91  LRVVYEDDKIIVIDKPAGMVVHPSPGHYDNTLVNALIARYPDLLKQPTDRPGIVHRLDKD 150

Query: 57  TSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADKF 115
           TSG++++    +    L  Q +  +I K Y  +  G L   E  ++ P+  +L       
Sbjct: 151 TSGLIIVARDLDTLNYLQGQMKARKIFKEYTLLCCGALDPPEGRIEAPIGRDLRDRTKMS 210

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
                G + AVT Y  + ++            +Y L    P TGR HQ+R H A + HPI
Sbjct: 211 VI--AGGKEAVTEYSTIQSL-----------GKYTLAIARPITGRTHQIRVHFAAIGHPI 257

Query: 176 IGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
            GD  +G+ R         GL R  LHAS+L +  P  GE    H+ L +   Q+L +
Sbjct: 258 AGDPIYGNCRLE-------GLNRQFLHASRLGVVMP-NGEYKEWHSPLPEDLRQSLEK 307


>UniRef50_Q2S3B7 Pseudouridine synthase n=1 Tax=Salinibacter ruber DSM 13855
           RepID=Q2S3B7_SALRD
          Length = 349

 Score =  251 bits (641), Expect = 2e-65,   Method: Composition-based stats.
 Identities = 68/286 (23%), Positives = 108/286 (37%), Gaps = 54/286 (18%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVR--------------------- 40
           L+++++ + L+ VNKP+G +VH +   R   +V                           
Sbjct: 74  LDVVHEGDDLLVVNKPAGMVVHPAPGHRSGTLVHALLHHVDGGEVAADDERDEVSEDEVG 133

Query: 41  -----------DQIGQHVFTAHRLDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAI 89
                      D         HRLD+ TSG+L++     A + LA+QF+ H + +RY AI
Sbjct: 134 LSLVNALPQSPDHPVVRPGIVHRLDKGTSGLLVVAKRGRAHQPLAEQFKAHTVDRRYRAI 193

Query: 90  VRGWL-MEEAVLDYPLVEELDKIADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTR 148
           V G     +  ++  +  +           +   + A THY  + T              
Sbjct: 194 VWGRFAPSDGTIEGAIGRDPHHRQRMAVVPEDEGKWARTHYETVET-----------HAH 242

Query: 149 YGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHGDLR--------QNRSGAEHF--GLQR 198
             +VE E +TGR HQ+R H     HP++GD K+G  R          R+  +     L  
Sbjct: 243 TSVVEFELETGRTHQIRVHARAQGHPLLGDPKYGGQRVRYGTQSGTRRTFYDQLFETLPH 302

Query: 199 LMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWRGLLPENE 244
             LHA +L   HP T E L   A     W + L +          +
Sbjct: 303 PALHAYRLGFDHPTTEERLRFEADPPPAWRRVLRELRQEEGAGTTD 348


>UniRef50_C1SM47 Pseudouridine synthase n=1 Tax=Denitrovibrio acetiphilus DSM 12809
           RepID=C1SM47_9BACT
          Length = 302

 Score =  250 bits (640), Expect = 3e-65,   Method: Composition-based stats.
 Identities = 59/235 (25%), Positives = 102/235 (43%), Gaps = 23/235 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVR----DQIGQHVFTAHRLDRPT 57
           +EI+Y  +    +NKP+G  VH +    D+ +V          D         HRLD+ T
Sbjct: 81  IEIIYDCDEFAVINKPAGITVHPAPGHADDTIVNAMLAEFDITDDNDLRPGIVHRLDKDT 140

Query: 58  SGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADKFA 116
           SG++++  + ++  +L++ F    I KRY A+  G   E E  ++ P+            
Sbjct: 141 SGLMIVAKNRKSREVLSKVFADRDIDKRYLAVCWGKPKELEFTIEQPIGRHYKDRKRMCV 200

Query: 117 REDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPII 176
           RED   + + +  R L                  L E+   TGR HQ+R H++H   P+ 
Sbjct: 201 RED--GRYSKSGVRVLKQ-----------NNNAFLAEIRIFTGRTHQIRVHMSHAGFPLA 247

Query: 177 GDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
           GD  +G  +  +       ++R  LH+ +L+   PFTGE +   + L     + +
Sbjct: 248 GDVVYGHRQSLK-----LPIKRQALHSFRLAFVSPFTGEDMVFESPLPLDMKELI 297


>UniRef50_A0LPH5 Pseudouridine synthase n=1 Tax=Syntrophobacter fumaroxidans MPOB
           RepID=A0LPH5_SYNFM
          Length = 344

 Score =  250 bits (640), Expect = 3e-65,   Method: Composition-based stats.
 Identities = 71/266 (26%), Positives = 117/266 (43%), Gaps = 29/266 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVM------QTVRDQIGQHVFTAHRLDR 55
           LEIL++D+ ++ +NK  G +VH      +  +V        +       +     HRLDR
Sbjct: 87  LEILFEDDDVLVLNKAPGVIVHPGAGHEEGTLVHGLLAHCSRLASRGAPRRPGIVHRLDR 146

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADK 114
            TSG L++  S  A   L +QF+ H++ K Y A+V G +      +   +         +
Sbjct: 147 GTSGALMVAKSERAYLELIRQFKHHEVGKEYLALVYGTMAGASGEIRTGMGRHPVD-RKR 205

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
            A  +KG + AV+ ++                    L+ +  KTGR HQ+R HL+H++HP
Sbjct: 206 MAVLEKGGREAVSQWKVA-----------VAWGEVSLLRVVIKTGRTHQIRVHLSHMQHP 254

Query: 175 IIGDSKHGDLRQNRSGAEHFGL-------QRLMLHASQLSLTHPFTGEPLTIHAGLDDTW 227
           ++GD  +G  ++     +   L        R MLHA  L+  HP +G  L+  A L   +
Sbjct: 255 VVGDETYGGGKRKARAVKSDVLRELLMEVDRQMLHAVGLAFRHPVSGADLSFTAPLPPDF 314

Query: 228 MQALSQFGWRGLLPENERVEFSAPSG 253
              L +     +  + E    S PSG
Sbjct: 315 AGLLERIR---ISLQKEGAGRSDPSG 337


>UniRef50_C8S0A2 Pseudouridine synthase n=1 Tax=Rhodobacter sp. SW2
           RepID=C8S0A2_9RHOB
          Length = 356

 Score =  250 bits (640), Expect = 3e-65,   Method: Composition-based stats.
 Identities = 66/264 (25%), Positives = 104/264 (39%), Gaps = 40/264 (15%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRD-----QIGQHVFTAHRLD 54
           L ++++D  L+ V+KP G +VH +       +V  ++    D        +     HR+D
Sbjct: 99  LTVVWEDADLIVVDKPVGMVVHPAPGSYTGTLVNALLHHCGDTLSGVGGAKRPGIVHRID 158

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL---------------MEEAV 99
           + TSG+L++  +  A   LA QFE H + + Y A+V G                     +
Sbjct: 159 KDTSGLLVVAKTDRAHHGLAAQFEAHSVTRHYIALVHGAPNAADPRLRGIRGVSFEPGGI 218

Query: 100 --LDYPLVEELDKIADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPK 157
             +   L         +    D G + AVT  R L +   P            LVE   +
Sbjct: 219 VCIATNLARHKTDRQRQAVLFDSG-RHAVTRVRVLESYGTPPV--------AALVECWLE 269

Query: 158 TGRKHQLRRHLAHLRHPIIGDSKHGDLRQNRSGA-------EHFGLQRLMLHASQLSLTH 210
           TGR HQ+R H++H  H ++GD  +G  R+    A             R  LHA+ L   H
Sbjct: 270 TGRTHQIRVHMSHAGHALLGDQTYGGRRKVAPKAVGEAVAQAANDFPRQALHAASLGFVH 329

Query: 211 PFTGEPLTIHAGLDDTWMQALSQF 234
           P +GE L   + L        +  
Sbjct: 330 PVSGEELLFTSPLPADMAALTAAL 353


>UniRef50_D0L1K7 Pseudouridine synthase n=1 Tax=Halothiobacillus neapolitanus c2
           RepID=D0L1K7_HALNC
          Length = 346

 Score =  250 bits (639), Expect = 4e-65,   Method: Composition-based stats.
 Identities = 81/248 (32%), Positives = 123/248 (49%), Gaps = 21/248 (8%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLM 63
           I+Y+DE L+AVNKP+G  VH         + +M+     +G+ +  AHR+DR TSG+L++
Sbjct: 111 IVYEDEALLAVNKPAGLAVHGGSNIPFGLIELMRQ-HTGLGEKLELAHRIDRDTSGLLIL 169

Query: 64  GLSSEAGRLLAQQFE-QHQIQKRYHAIVRG-WLMEEAVLDYPLVEELDKIADKFAREDKG 121
             +      L  QF  +   +K+Y AIV G W  +   +D PL +   +      + +  
Sbjct: 170 AKTRATLHSLQTQFRPEGHAEKQYLAIVHGHWPDKLKRVDAPLEKWQGEGESHRVQVNPQ 229

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
            + AVTH+  LA                 L+  + +TGR HQ+R H AH  HPI+GD K+
Sbjct: 230 GKEAVTHFAVLA-----------ANKNATLLRAQLETGRTHQIRVHTAHENHPIVGDEKY 278

Query: 182 GDLRQNR-----SGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGW 236
           G    ++     +GA       L+LHA +L LTHP T +PL + A + D W     Q   
Sbjct: 279 GQREWDKRLFPSTGASARRRPPLLLHAYRLMLTHPQTEQPLQLTAPIPDKWRSLAQQLNL 338

Query: 237 RGLLPENE 244
              LPE++
Sbjct: 339 --TLPEHD 344


>UniRef50_C0Z877 Pseudouridine synthase n=1 Tax=Brevibacillus brevis NBRC 100599
           RepID=C0Z877_BREBN
          Length = 310

 Score =  250 bits (639), Expect = 4e-65,   Method: Composition-based stats.
 Identities = 70/235 (29%), Positives = 108/235 (45%), Gaps = 24/235 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQH--VFTAHRLDRPTSG 59
           ++ILY+D+ L+  NKP+G +VH    + D  V  +  V    G+   V   HRLD+ TSG
Sbjct: 94  IDILYEDDHLLIANKPAGMMVHPIKQETDTLVHALAAVLAARGEQTSVHPVHRLDKDTSG 153

Query: 60  VLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADKFARE 118
            +L+  SS   +L  +   +  I + Y A+  G L E    +D P+  +      +   E
Sbjct: 154 AILVAKSSYGHQLADRLLREGGIHREYLAVASGVLSEGAGTIDAPIGRDARHPTKRRVVE 213

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
                PA+THY    T E              L  +  +TGR HQ+R H AH+ HP+ GD
Sbjct: 214 S--GDPAITHYEVQQTSEEM-----------TLARVWLETGRTHQIRVHFAHIGHPLAGD 260

Query: 179 SKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           + +G  R          L+R  LHAS+LS  HP   + + + A +     + +  
Sbjct: 261 TMYGGARG--------LLRRQALHASKLSFLHPLLEKEIVVEAPIPSDMKRLMQA 307


>UniRef50_A8RHQ2 Pseudouridine synthase n=2 Tax=Clostridium RepID=A8RHQ2_9CLOT
          Length = 287

 Score =  250 bits (639), Expect = 4e-65,   Method: Composition-based stats.
 Identities = 66/233 (28%), Positives = 107/233 (45%), Gaps = 21/233 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVF---TAHRLDRPTS 58
           L I+Y+DE ++ +NK +G  +H S    D  +    +         F     +RLDR T+
Sbjct: 69  LSIVYEDEDILVINKDAGVPIHPSQGHYDNTLANAVSWYFHEKGEAFTYRVINRLDRDTT 128

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           G+L++     +  +L++Q    +I++ Y AIV G   EE  +D P+        ++    
Sbjct: 129 GLLVLARHMLSACILSEQMTGRRIRREYRAIVLGHTPEEGTVDSPIARAEGSTIERRVDH 188

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
           + G + AVTH+R L   E              LV L  +TGR HQ+R H+  + HP+ GD
Sbjct: 189 ETGER-AVTHFRTLLYNEEK---------DLSLVSLSLETGRTHQIRVHMRSIGHPLPGD 238

Query: 179 SKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
             +          ++  + R  LH+  L   HP TG+ +   AGL +   Q L
Sbjct: 239 FLY--------CPDYRYIDRQPLHSYLLRFEHPITGKEMEFTAGLPEDMKQLL 283


>UniRef50_O67638 Uncharacterized RNA pseudouridine synthase aq_1758 n=3
           Tax=Aquificaceae RepID=Y1758_AQUAE
          Length = 316

 Score =  250 bits (639), Expect = 4e-65,   Method: Composition-based stats.
 Identities = 64/247 (25%), Positives = 113/247 (45%), Gaps = 21/247 (8%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIG----QHVFTAHRLDR 55
           + I+Y+DE +  V KP G +VH S       +V  ++  ++D       +     HRLD+
Sbjct: 82  INIIYEDEDIAVVEKPCGLVVHPSPGYTSGTLVNALLYHIKDLSSIGGVERPGIVHRLDK 141

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADK 114
            T+GV+++  ++ A R L +QF++ + +K Y  +V+G + ++   +D P+          
Sbjct: 142 ETAGVMVIAKNNTAHRNLVRQFQERKTEKFYKVLVKGLVKKDYGAIDTPIARHPVDRKRF 201

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
           + R++   + A+T Y  L          RY      L++++  TGR HQ+R H A + HP
Sbjct: 202 WVRKE--GKEALTEYWVLK---------RYEKYEITLLKVKIHTGRTHQIRVHFASIGHP 250

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQR--LMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALS 232
           ++GD  +G  + +    E   L     ML A  L   HP  GE +       +T+    S
Sbjct: 251 VLGDRTYG-FKSSSVPKELLSLMGECNMLIAYHLGFYHPTKGEWMVFEIEEPETFKSVYS 309

Query: 233 QFGWRGL 239
                  
Sbjct: 310 WLEEHSP 316


>UniRef50_Q0F3G4 Pseudouridine synthase n=1 Tax=Mariprofundus ferrooxydans PV-1
           RepID=Q0F3G4_9PROT
          Length = 315

 Score =  249 bits (638), Expect = 5e-65,   Method: Composition-based stats.
 Identities = 75/231 (32%), Positives = 115/231 (49%), Gaps = 11/231 (4%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           + +LY+D+ L+ VNKP+G +VH         +  ++  R      +  AHRLDR TSGVL
Sbjct: 94  IPVLYEDDSLLVVNKPAGMVVHGGSGHEAGLIEALKQSRGL--DDLRLAHRLDRDTSGVL 151

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADKFAREDK 120
           LM    +A R L + F +  +QK Y A++ G        +   L + + +  ++   + +
Sbjct: 152 LMAKHLDALRRLTESFRERDMQKTYFALIAGHPYAHAGRMSSNLAKGVVRGGERMVVDSE 211

Query: 121 GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSK 180
             + +VT Y+ +   E            Y +V L P +GR HQLR  L H  HPI+GD K
Sbjct: 212 EGKASVTDYQVMIEYERH-------GFPYAMVALNPHSGRTHQLRVQLQHEGHPILGDGK 264

Query: 181 HGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
           +G+  Q  +  +  G + LMLHA +L  THP +G+ L   A   D W   L
Sbjct: 265 YGEKAQ-LAAYKSLGGKGLMLHAWRLRFTHPVSGKSLECKAPWPDNWSALL 314


>UniRef50_C6LL16 Pseudouridine synthase n=3 Tax=Clostridiales RepID=C6LL16_9FIRM
          Length = 313

 Score =  249 bits (638), Expect = 5e-65,   Method: Composition-based stats.
 Identities = 65/234 (27%), Positives = 107/234 (45%), Gaps = 25/234 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFT---AHRLDRPTS 58
           L+I+Y+DE L+ ++KP+   VH S  + D  +        +     F      RLDR T+
Sbjct: 85  LDIVYEDEDLLVIDKPADMPVHPSIHNFDNTLANGLAYYYESRGEAFVYRCITRLDRDTT 144

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           G+LL+  +  +G  LA+  ++ +I + Y AIV G    E  +D P+      + ++    
Sbjct: 145 GLLLVAKNMLSGAFLAEMGKRREIHREYLAIVTGKTEAEGTVDAPIARVEGSVLERCVDF 204

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
            +G + AVTHYR L                Y LV L+ +TGR HQ+R H+ ++ HP+ GD
Sbjct: 205 QRGER-AVTHYRTLEY-----------RDGYSLVRLKLETGRTHQIRVHMKYIGHPLTGD 252

Query: 179 SKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALS 232
             +          ++  +    LH+  L+  HP TGE +   +     W     
Sbjct: 253 FLY--------NPDYRLMDHQALHSHYLAFRHPITGERMEFTSQPP--WQGLWE 296


>UniRef50_A1HR26 Pseudouridine synthase, RluA family n=1 Tax=Thermosinus
           carboxydivorans Nor1 RepID=A1HR26_9FIRM
          Length = 301

 Score =  249 bits (638), Expect = 5e-65,   Method: Composition-based stats.
 Identities = 71/240 (29%), Positives = 110/240 (45%), Gaps = 26/240 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKV---VVMQTVRDQIGQHVFTAHRLDRPTS 58
           L I+Y+D++L+ VNKP+G LVH +    +  +   ++               HRLDR TS
Sbjct: 75  LHIVYEDDFLLIVNKPAGLLVHPTSDPTEPTLAHGILYYLHSKGALGAFHPIHRLDRNTS 134

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADKFAR 117
           G++ +         L+       +++ Y A+V G        +D P+    + I  +  R
Sbjct: 135 GLVAIAKHPHIQHALSGG-GAKGLKRLYLAVVTGIPSSLMGRIDAPIGRHPNSIIKRVVR 193

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
            D   QPA+T YR L+T  M             LVELE  TGR HQ+R HL+H+ HP++G
Sbjct: 194 SD--GQPAITLYRVLSTFSM-----------ASLVELELLTGRTHQIRVHLSHIGHPLLG 240

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWR 237
           D  +G             ++R  LHA+ LS  HP T + LT+ + L       +     +
Sbjct: 241 DDLYGGATD--------LIRRQALHAASLSFRHPATDKVLTLTSPLPPDLADLIQLLRQK 292


>UniRef50_A6LDZ7 Pseudouridine synthase n=26 Tax=Bacteroidales RepID=A6LDZ7_PARD8
          Length = 549

 Score =  249 bits (638), Expect = 6e-65,   Method: Composition-based stats.
 Identities = 77/234 (32%), Positives = 109/234 (46%), Gaps = 35/234 (14%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           L+ILY+D++L+ +NKP G L      D D     +  +  +        HRLD  TSG+L
Sbjct: 340 LDILYEDDYLLVINKPEGMLSVPGKGDADSVYQRLSILYPE-ATGPIIVHRLDMATSGLL 398

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADKFAREDK 120
           L   + EA + L  QF+   IQKRY A++ G +  +E  +  PL  +      +   E+ 
Sbjct: 399 LAAKTKEAHQNLQAQFKNRTIQKRYIALLEGEVPQDEGEIRLPLCPDPLDRPRQIVSEEF 458

Query: 121 GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAH---LRHPIIG 177
           G +PA+THYR L             T+   L+   P+TGR HQLR H AH   L  PI+G
Sbjct: 459 G-KPALTHYRVLER-----------TSGKTLIAFYPQTGRTHQLRVHAAHPLGLHCPILG 506

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIH-------AGLD 224
           D  +G              +RL LHA  L+ THP T E + I          + 
Sbjct: 507 DELYGRK-----------AERLYLHAEYLAFTHPITSERIEIQKSPAFPRCPMP 549


>UniRef50_A4RT55 Predicted protein (Fragment) n=3 Tax=Chlorophyta RepID=A4RT55_OSTLU
          Length = 332

 Score =  249 bits (637), Expect = 8e-65,   Method: Composition-based stats.
 Identities = 64/273 (23%), Positives = 109/273 (39%), Gaps = 57/273 (20%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ---------------- 45
           L+I+++DE ++ VNK +G + H S       +V        + +                
Sbjct: 70  LDIVHEDESVLVVNKAAGMVTHPSAGHESGTLVNAVLGHCDLPELVVPTGNQALSDDDED 129

Query: 46  ----------------HVFTAHRLDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAI 89
                                HRLD+ TSGV+++   + A   L +QF    ++++Y AI
Sbjct: 130 DEDAVDEDEGARDGMIRPGIVHRLDKGTSGVMVVAKDASAHNSLCEQFAARVVRRKYVAI 189

Query: 90  VRGWL-MEEAVLDYPLVEELDKIADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTR 148
           + G     +  ++ P+  +  +   + A    G + A ++Y  +AT+             
Sbjct: 190 LSGVPSPSKGRIEAPIGRDP-RDRLRMAVTQGGGRFAASNYEVIATL---------ANGN 239

Query: 149 YGLVELEPKTGRKHQLRRHLAHLRHPIIGDS--------------KHGDLRQNRSGAEHF 194
             LVE   +TGR HQ+R H  H+ HPI+GD               ++G      + A   
Sbjct: 240 ASLVEWRLETGRTHQIRVHAKHIGHPILGDDTYGGGGGAAVSALSRYGVFDVKEAKALMS 299

Query: 195 GLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTW 227
            + R MLHA  L  THP +GE L       + +
Sbjct: 300 TIDRPMLHARTLGFTHPQSGEALDFSRDPPEDF 332


>UniRef50_Q5PAD0 Pseudouridine synthase n=5 Tax=Anaplasma RepID=Q5PAD0_ANAMM
          Length = 327

 Score =  248 bits (635), Expect = 1e-64,   Method: Composition-based stats.
 Identities = 60/255 (23%), Positives = 100/255 (39%), Gaps = 21/255 (8%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG-------QHVFTAHRLD 54
           L+++Y+D  ++ ++K     VH         +      R   G             HRLD
Sbjct: 82  LKVVYEDHDVIVIDKDPYIAVHPGNGIEHHTITNALLARFGAGLQSVGSSSRPGIVHRLD 141

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADK 114
           + TSG+++   +  A   L+++      +K Y A+  G    +  + +  +         
Sbjct: 142 KDTSGLMVAAKTENAYYRLSEELANQGFKKEYLAVAWGIPCPKRGVIHTNIRVKRSDITM 201

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
               + G +PA T Y     +               L+     TGR HQ+R H++H+ H 
Sbjct: 202 MEAANSGGKPAKTEYEVEQELGEV----------ASLIRCTLHTGRTHQIRVHMSHIGHS 251

Query: 175 IIGDSKHGD--LRQNRSG--AEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQA 230
           I+GD K+G    +  RSG   +    +R  LHAS L   HP TG+ +   +   D   Q 
Sbjct: 252 IVGDQKYGKNCKKCMRSGVPPDVKNFRRQALHASLLGFRHPSTGKYIEFTSKPADDIQQL 311

Query: 231 LSQFGWRGLLPENER 245
           +S     G L    R
Sbjct: 312 ISALERAGNLQARNR 326


>UniRef50_B6J6C4 Pseudouridine synthase n=7 Tax=Coxiella burnetii RepID=B6J6C4_COXB1
          Length = 327

 Score =  248 bits (635), Expect = 1e-64,   Method: Composition-based stats.
 Identities = 65/243 (26%), Positives = 108/243 (44%), Gaps = 22/243 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQ---IGQHVFTAHRLDRPTS 58
           L+++Y+DE L+ +NKP G +VH     RD+ ++      D    +       HRLD+ TS
Sbjct: 89  LDVIYEDETLLVINKPVGLIVHPGAGVRDQTLINALLHYDPSLSVVPRAGIIHRLDKDTS 148

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           G+LL+  +  +   L +  +  QI + Y AIV+G L+    ++ P+             E
Sbjct: 149 GLLLIARTLASHHALIKAMKARQIVREYEAIVKGVLISGRTIEAPVGRHPIHRTRMAVVE 208

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
               +PA+TH+R +                +  + ++ +TGR HQ+R H+AH+ HP+ GD
Sbjct: 209 --FGRPAITHFRIIKRYRA-----------HTHIRVQLETGRTHQIRVHMAHIHHPLAGD 255

Query: 179 SKHGDLR------QNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALS 232
             +G          +        L+R  LH + L  +HP    P+  HA L       L 
Sbjct: 256 PVYGSHVGIPVHLSDPLQTALKTLKRQALHGATLQFSHPVDQRPMACHAPLPADMAHLLE 315

Query: 233 QFG 235
              
Sbjct: 316 CLE 318


>UniRef50_D1AV01 Pseudouridine synthase n=2 Tax=Bacteria RepID=D1AV01_STRM9
          Length = 297

 Score =  248 bits (635), Expect = 1e-64,   Method: Composition-based stats.
 Identities = 66/239 (27%), Positives = 121/239 (50%), Gaps = 27/239 (11%)

Query: 5   LYQDEWLVAVNKPSGWLVHRSWLDRDEKVVV--MQTVRDQIGQ----HVFTAHRLDRPTS 58
           +Y+D++L  +NK +G +VH S    ++ +V   M  ++D  G          HRLD+ TS
Sbjct: 78  VYEDKYLAIINKYAGMVVHPSKGHEEDTLVNAIMYKIKDLSGINGDLRPGIVHRLDKNTS 137

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           G++++    +    L++ F+  +I+K Y+AIV+G + +++     ++        K A  
Sbjct: 138 GLIIIAKDDKTHFKLSEMFKNKEIKKIYYAIVKGKVNKKSGRIETMIGRNPNDRKKMAVV 197

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
           D G + A+T++  + + E           ++ L++++ +TGR HQ+R HL+H   PI+GD
Sbjct: 198 DNG-KLAITNFEVIDSNE-----------KFSLLKVDLETGRTHQIRVHLSHFFFPILGD 245

Query: 179 SKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWR 237
           S +G   +           R MLHA  L+  HP T E + +       +++ALS    R
Sbjct: 246 SVYGRKDE---------YDRQMLHAYMLNFIHPITLEKIDVIGNFHSDFLRALSNTKLR 295


>UniRef50_C0QPR5 Pseudouridine synthase n=4 Tax=Hydrogenothermaceae
           RepID=C0QPR5_PERMH
          Length = 319

 Score =  248 bits (635), Expect = 1e-64,   Method: Composition-based stats.
 Identities = 58/245 (23%), Positives = 106/245 (43%), Gaps = 22/245 (8%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQI------GQHVFTAHRLDR 55
           ++IL++DE +  V KP+G +VH S       +V       +        +     HRLD+
Sbjct: 85  VDILFEDEDIAVVYKPAGMVVHPSPGHTSGTLVNALLYHFRNISEYGGKERAGIVHRLDK 144

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADK 114
            T+G++++  S  A + L +QF++  + KRY A+V G +  +   +D P+   +     K
Sbjct: 145 DTAGLMIIAKSEFAHKELQKQFQERTVDKRYIAVVTGIVQNDHGFIDLPIGRSIYN-RKK 203

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
              E    + A+T Y             R       +V+++  TGR HQ+R H + + HP
Sbjct: 204 MGTEATNLRDALTEYWV---------KNRSEKENLTVVDIKLHTGRTHQIRVHFSAIGHP 254

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRL----MLHASQLSLTHPFTGEPLTIHA-GLDDTWMQ 229
           +  D  +G  +      +   +        L A +++  HP TGE + I    L +   +
Sbjct: 255 LFNDKVYGFKKSQLRSEKMRSISDQTLYHALLAYRIAFDHPRTGEKIDITLQKLPEHISK 314

Query: 230 ALSQF 234
            +   
Sbjct: 315 VIEAI 319


>UniRef50_Q01Q94 Pseudouridine synthase n=1 Tax=Candidatus Solibacter usitatus
           Ellin6076 RepID=Q01Q94_SOLUE
          Length = 296

 Score =  248 bits (635), Expect = 1e-64,   Method: Composition-based stats.
 Identities = 73/240 (30%), Positives = 108/240 (45%), Gaps = 27/240 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ------HVFTAHRLDR 55
           L ILY+D  +VA++KP+G +VH         +V     R                HRLDR
Sbjct: 77  LRILYEDADVVAIDKPAGMVVHAGAGVHSGTLVNALLHRFATLSGVGGPLRPGIVHRLDR 136

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADK 114
            TSGVLL+  +  A + LA QF   +I+K Y A+V G +  E   ++ P+  +    A  
Sbjct: 137 FTSGVLLVAKNDAAHQKLAAQFSGREIEKVYLALVHGTVKPETGRIERPIARDPVHRARM 196

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
            AR  +G + A + YR L                + L+E+   TGR HQ+R HLA +RHP
Sbjct: 197 TARLAEG-RAAWSEYRVLRRF-----------PDFTLLEVRIGTGRTHQIRVHLASIRHP 244

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           ++GD+ +G             L R  LHA ++    P +G  + I + L       L   
Sbjct: 245 VVGDTLYG-------APAQPLLGRYFLHAHRIRFHLP-SGREMLIESPLPPDLEAWLGTL 296


>UniRef50_B5YAZ5 Pseudouridine synthase n=2 Tax=Dictyoglomus RepID=B5YAZ5_DICT6
          Length = 226

 Score =  247 bits (633), Expect = 2e-64,   Method: Composition-based stats.
 Identities = 66/237 (27%), Positives = 116/237 (48%), Gaps = 26/237 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVF-----TAHRLDRP 56
           LE++Y+D  L+ VNKP+G LV          + + +    +  +          HRLD+P
Sbjct: 7   LEVIYEDNHLLVVNKPAGILVQGDITKSTTLLEISKAYIKEKYKKPGNVFLAIVHRLDKP 66

Query: 57  TSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADKF 115
            SGV++   +S++   L++ F + +++K Y A+ +G    ++  +   L+  ++K     
Sbjct: 67  VSGVVIFARNSKSAGRLSEAFRERKVEKEYIALCKGIFKVKKGTISESLL-WVEKERKAR 125

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
             +D   + A+THY  L   +              LV L P+TGRKHQLR HL+++ HPI
Sbjct: 126 VSQDDKSKNAITHYEVLEEFK-----------NLSLVRLIPETGRKHQLRAHLSYIGHPI 174

Query: 176 IGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALS 232
           +GD K+G  R  +         R+ LH  ++++ HP   + +   A + D W + L 
Sbjct: 175 LGDEKYGGGRIFK--------DRIFLHCKKMAVPHPVRKDIMEFEAKIPDFWSEFLK 223


>UniRef50_O31613 Uncharacterized RNA pseudouridine synthase yjbO n=53
           Tax=Bacillaceae RepID=YJBO_BACSU
          Length = 283

 Score =  247 bits (631), Expect = 3e-64,   Method: Composition-based stats.
 Identities = 65/235 (27%), Positives = 103/235 (43%), Gaps = 25/235 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVM---QTVRDQIGQHVFTAHRLDRPTS 58
           L+ILY+DE ++ +NK        S       +            +   V    RLDR TS
Sbjct: 66  LDILYEDEHVLVINKQPYVSSIPSREHPSGSIANGIIDHYQTTGVRATVHLVTRLDRDTS 125

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADKFAR 117
           G++L+     A  +L+   +   +++RY A+V G + + E  +D P+    D I ++   
Sbjct: 126 GIMLVAKHRFAHSILSSAQKNGLVKRRYAAVVHGRMAQMEGTVDAPIGRHPDSIIERTVT 185

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
            D   Q AVTH+                      V L+ +TGR HQ+R H+++L HP+ G
Sbjct: 186 PD--GQKAVTHFYV-----------TCANDDMTSVALQLETGRTHQIRVHMSYLGHPLCG 232

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALS 232
           D+ +G  RQ         + R  LH+  LS  HP T E +  HA L     + + 
Sbjct: 233 DTLYGGTRQE--------IGRQALHSEHLSFIHPLTQENMRFHAPLPQDMSKLIK 279


>UniRef50_C2D7A7 Pseudouridine synthase n=1 Tax=Atopobium vaginae DSM 15829
           RepID=C2D7A7_9ACTN
          Length = 338

 Score =  247 bits (631), Expect = 4e-64,   Method: Composition-based stats.
 Identities = 58/247 (23%), Positives = 109/247 (44%), Gaps = 18/247 (7%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKV---VVMQTVRDQIG-----QHVFTAHRL 53
           L+I Y+D++L+ ++K +G + H S    D+ +   +V     + +G           HRL
Sbjct: 86  LDIRYEDDYLLVISKQTGLVCHPSPGHVDDTLSNALVAHCGYEHLGLLQGDDRPGIVHRL 145

Query: 54  DRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIA 112
           D  T+G+++    +   + L          +RY  +V+G++  +E  +   +        
Sbjct: 146 DMDTTGLMVAAKDNTTQQALQDLIRLRVFDRRYIVLVQGYVTPDEGTITTGIARSKKNRL 205

Query: 113 DKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLR 172
                +D   + A+T ++ L   E            Y L+E    TGR HQ+R H+ ++ 
Sbjct: 206 KMCISKDPASREAITTFKTLERFE-----AGSKDDGYSLLECHLYTGRTHQIRVHMRYVG 260

Query: 173 HPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALS 232
           H ++GD  +G     +  A + GLQR  LH+ ++S  HP T E L     L     + L+
Sbjct: 261 HSVVGDPLYGR----KGDALNQGLQRQFLHSWRMSFDHPITHEHLQFCDKLPSDLSEVLA 316

Query: 233 QFGWRGL 239
           +   + +
Sbjct: 317 RLQPQSM 323


>UniRef50_C9M7B4 Pseudouridine synthase n=1 Tax=Jonquetella anthropi E3_33 E1
           RepID=C9M7B4_9BACT
          Length = 301

 Score =  246 bits (630), Expect = 4e-64,   Method: Composition-based stats.
 Identities = 67/235 (28%), Positives = 102/235 (43%), Gaps = 22/235 (9%)

Query: 5   LYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTV----RDQIGQHVFTAHRLDRPTSGV 60
           +Y D+WL  V K +G  VH     +D  +V             G      HRLD  TSG+
Sbjct: 81  VYADDWLAVVEKLAGIAVHPGAGRKDGTLVNGLVKTFGPLPGAGLRPGIVHRLDIGTSGL 140

Query: 61  LLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADKFARED 119
           +++  + +A   L ++F Q +++K Y A+V GW+   +  LD P+            R D
Sbjct: 141 MVVARTPQAYLFLQREFSQRRVEKTYLALVHGWIPASQGTLDGPIGRSRYDRLKMAVRAD 200

Query: 120 KGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDS 179
              + AVT YR L T                L     +TGR HQ+R H+A +   + GD 
Sbjct: 201 --GRRAVTRYRTLWT-----------RGSLSLTACRIETGRTHQIRVHMASIGCYLDGDR 247

Query: 180 KHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
            +G     +  + HF   R+ LHA +LS  HP  G  +   + L D  +  L + 
Sbjct: 248 LYGP----KDVSRHFLEGRVFLHAWRLSFHHPSDGRTMNFRSPLPDELIGVLKKI 298


>UniRef50_C0N6T7 Pseudouridine synthase n=1 Tax=Methylophaga thiooxidans DMS010
           RepID=C0N6T7_9GAMM
          Length = 318

 Score =  246 bits (630), Expect = 5e-64,   Method: Composition-based stats.
 Identities = 71/235 (30%), Positives = 125/235 (53%), Gaps = 14/235 (5%)

Query: 3   EILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLL 62
           +I+++D+ ++ +NKPSG  VH     +   +   + ++ ++   +   HRLDR TSG LL
Sbjct: 96  DIIFEDDSMLVLNKPSGLAVHAGSQIQVGVIEAFRIIKPELA-FLELVHRLDRDTSGCLL 154

Query: 63  MGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADKFAREDKG 121
           +  S ++   L QQ    QI KRY  +++G L   E +++ PL++      ++  +    
Sbjct: 155 LAKSRDSLLNLQQQMLSDQIDKRYLTLLKGILPNAEELVEQPLLKNTVSSGERMVKVTPD 214

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
            + A T +  +   ++ +A          L E++  TGR HQ+R H A  +HP+ GD K+
Sbjct: 215 GKRAKTLF--IRQQDLSLAQ---------LTEVKLYTGRTHQIRVHAAWTQHPVAGDDKY 263

Query: 182 GDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGW 236
           GD   N++  + FGL+RL LHA +L + HP +GEP+ + A L     Q +++   
Sbjct: 264 GDREFNKTL-KSFGLKRLFLHAWRLGIRHPVSGEPMQLEAPLPTALQQVITKLEL 317


>UniRef50_B1ZYX0 Pseudouridine synthase n=4 Tax=Verrucomicrobia RepID=B1ZYX0_OPITP
          Length = 311

 Score =  246 bits (630), Expect = 5e-64,   Method: Composition-based stats.
 Identities = 66/241 (27%), Positives = 108/241 (44%), Gaps = 23/241 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG-------QHVFTAHRLD 54
           L +L++D+ ++AVNK +G +VH      ++ +V                 +     HRLD
Sbjct: 80  LTVLFEDKHMLAVNKAAGMVVHPGVATSEDTLVHALLAHCAGSLSGIGGVERPGIVHRLD 139

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIAD 113
           + T+GV+++  +  A R LA QF    ++K Y A+V G        +D  +      +  
Sbjct: 140 KETTGVIVVAKTDAAHRALADQFATRTLKKEYVALVAGVPRLLSGSIDRAIARHP--VHR 197

Query: 114 KFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
                 +G +PA T +  +                  LV     TGR HQ+R HL  L H
Sbjct: 198 HRMTVGEGGRPARTDWELVEAFGDIG----------ALVRCRIFTGRTHQIRVHLKSLGH 247

Query: 174 PIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           PI+GD+ +G   + R   +     R+MLHA  L LTHP +G+ L + A L   ++  + +
Sbjct: 248 PILGDALYGWKPEPRLATQPA---RVMLHAEHLVLTHPISGKELDLRAPLPKDFVAMIKE 304

Query: 234 F 234
            
Sbjct: 305 L 305


>UniRef50_C5S931 Pseudouridine synthase n=2 Tax=Gammaproteobacteria
           RepID=C5S931_CHRVI
          Length = 346

 Score =  246 bits (629), Expect = 6e-64,   Method: Composition-based stats.
 Identities = 78/234 (33%), Positives = 114/234 (48%), Gaps = 12/234 (5%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLM 63
           I+++DE L+ ++KPSG  VH         +  ++ +R   G+ +   HRLDR TSG L++
Sbjct: 122 IIHEDERLLVIDKPSGLAVHGGSGLSYGLIESLRQLRP--GRELELVHRLDRDTSGCLVV 179

Query: 64  GLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADKFARED-KG 121
                A R L     +  + KRY A++ G L   E ++D PL + +    ++  R D +G
Sbjct: 180 CKRRSALRELHALIREGGLDKRYLALILGELPRAELLVDAPLKKNVLSSGERLVRVDAQG 239

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
            + A T +R L    +             LVE E  TGR HQ+R H AHL  P+ GD K+
Sbjct: 240 GKEARTRFRRLKRFAID-------GQALTLVEAELITGRTHQIRVHAAHLGTPLAGDDKY 292

Query: 182 GDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFG 235
           GD   N+   + +GL+RL LHAS LS        PL +   L D   Q L    
Sbjct: 293 GDEAANQRL-KGYGLKRLFLHASALSFKLECMARPLRLECPLPDELQQVLDALE 345


>UniRef50_Q14NK8 Probable pseudouridine synthase d protein n=1 Tax=Spiroplasma citri
           RepID=Q14NK8_SPICI
          Length = 306

 Score =  246 bits (629), Expect = 6e-64,   Method: Composition-based stats.
 Identities = 74/244 (30%), Positives = 118/244 (48%), Gaps = 25/244 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVR------DQIGQHVFTAHRLDR 55
           L ILY+D +L+ ++KP+  +VH +   +++ +V     R          Q     HR+DR
Sbjct: 81  LTILYEDSYLMVIDKPNNLVVHPAPGHQNDTLVNALLARGVQWSTASGEQRPGIVHRIDR 140

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADK 114
            T+G L++  +      L QQ +  Q+Q+RY A+V G ++E  A +D P+  + +    K
Sbjct: 141 QTTGTLIIAKNDVVHHQLQQQIQTKQLQRRYLALVHGQIIENRAKIDAPIGRDPNN-RKK 199

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
                K  + A+T+   +                Y  +E E ++GR HQ+R HL ++ HP
Sbjct: 200 MVVTAKNSKKALTNIVVIERF-----------NDYTYIECELESGRTHQIRAHLKYINHP 248

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           I+GD  +G +   +   E FG     LHA QL   HP T E LTI A L   + Q L+  
Sbjct: 249 IVGDPLYGTVADKK---ESFG---QYLHAYQLRFIHPVTKESLTITAALPQEFEQRLAIL 302

Query: 235 GWRG 238
             +G
Sbjct: 303 RAKG 306


>UniRef50_B3DV48 Pseudouridine synthase n=1 Tax=Methylacidiphilum infernorum V4
           RepID=B3DV48_METI4
          Length = 325

 Score =  246 bits (629), Expect = 6e-64,   Method: Composition-based stats.
 Identities = 67/244 (27%), Positives = 104/244 (42%), Gaps = 24/244 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV---VMQTVRDQIGQ---HVFTAHRLDR 55
           LEILY+DE ++ VNK  G +VH S       +V   +        G         HRLD+
Sbjct: 91  LEILYEDEEILIVNKQRGMVVHPSCGHWSGTLVNSLLFHYGESLPGSSLLRPGIVHRLDK 150

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKF 115
            TSGV+++  +  + + L  QF Q  +QK Y  + +             +        K 
Sbjct: 151 DTSGVMVIAKTERSLKSLLLQFSQRTVQKVYLCLCKNRFPYLRYSFEANIHRHASDRKKM 210

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
           A      + A T +  L           + +++   ++ EP +GR HQ+R HL+HL  PI
Sbjct: 211 AVHRLKGKTAETRFTLL-----------FASSQASFLKCEPVSGRTHQIRVHLSHLGFPI 259

Query: 176 IGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFG 235
           IGD  +G   +            L+LHA  L + HP +G+ +   A L   + +AL  F 
Sbjct: 260 IGDPLYGKGVRKYPFP-------LLLHAYALKIEHPRSGKKIEFMAPLPQDFKEALDFFY 312

Query: 236 WRGL 239
            R  
Sbjct: 313 GRNF 316


>UniRef50_A8MF48 Pseudouridine synthase n=12 Tax=Clostridiaceae RepID=A8MF48_ALKOO
          Length = 305

 Score =  246 bits (628), Expect = 7e-64,   Method: Composition-based stats.
 Identities = 59/234 (25%), Positives = 105/234 (44%), Gaps = 24/234 (10%)

Query: 5   LYQDEWLVAVNKPSGWLVHRSWLDRDEKVV---VMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           +Y+D  L+ VNK  G + H +    D  +     +      I   V   +RLD  TSG+L
Sbjct: 89  VYEDVDLILVNKEPGIVTHPTKSHPDWTIANGAALYLKSKGIDCKVRFVNRLDMDTSGLL 148

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADKFAREDK 120
           ++  ++ A  +L++Q ++ +I+K+Y A V G + E E  ++ P+         +    D+
Sbjct: 149 IIAKNAYAHHVLSEQMQEDRIEKKYIAFVWGVIKEDEGRIEAPIYRTTMDSIKRVV--DE 206

Query: 121 GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSK 180
             Q ++T ++ L   +              +VE++  TGR HQ+R H+ HL HP+IGD+ 
Sbjct: 207 RGQESITEFKVLERYK-----------NATMVEVKLLTGRTHQIRVHMEHLGHPLIGDTL 255

Query: 181 HGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           +G         +   + R  LHA  L    P     + + A L    +    + 
Sbjct: 256 YGK-------EDAELIDRQALHAEYLRFWQPRFKRAIEVKADLPADLLSLRDKL 302


>UniRef50_A3DDK9 Pseudouridine synthase, RluA family n=3 Tax=Clostridium
           thermocellum RepID=A3DDK9_CLOTH
          Length = 318

 Score =  245 bits (627), Expect = 9e-64,   Method: Composition-based stats.
 Identities = 65/251 (25%), Positives = 104/251 (41%), Gaps = 31/251 (12%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKV---VVMQTVRDQIGQHVFTAHRLDRPTS 58
           ++I+Y+DE+L+A+NK  G +VH +       +   V     +  I + +    RLDR TS
Sbjct: 79  IDIIYEDEFLIALNKQPGIVVHPTCSHPGGTLANAVAFHLQKKGIVKKIRPVIRLDRDTS 138

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADKFAR 117
           G+++   +      L +Q       K Y  IV   L  +   +D P+  +   I  +   
Sbjct: 139 GIIIFAKNPYCQEFLIRQMNDKTFIKEYIGIVHKVLENDNGTIDLPIARKPGSIMLRHIS 198

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
            D    PAVTHY  L  +               LV+   +TGR HQ+R H   + HP++G
Sbjct: 199 PD--GDPAVTHYTVLERL-----------NGATLVKFRLETGRTHQIRVHCQAIGHPLLG 245

Query: 178 DSKH----------GDLRQ----NRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGL 223
           D+ +          G+       N        + R  LH+ +    HPFT + L I A +
Sbjct: 246 DTLYPFEDTPYSLSGNNPHITQANTPSITSGIITRQALHSQRAVFLHPFTKKILEITAPI 305

Query: 224 DDTWMQALSQF 234
            +    AL   
Sbjct: 306 PEDMKSALEIL 316


>UniRef50_Q0VQN9 Pseudouridine synthase n=2 Tax=Alcanivorax RepID=Q0VQN9_ALCBS
          Length = 317

 Score =  245 bits (627), Expect = 9e-64,   Method: Composition-based stats.
 Identities = 73/230 (31%), Positives = 115/230 (50%), Gaps = 14/230 (6%)

Query: 5   LYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLMG 64
           +Y+D+ L   NKP+G  VH         +  ++ +  Q  + +   HRLDR TSG++++ 
Sbjct: 98  VYEDDQLFVFNKPAGLAVHGGSGVSLGLIEALRVMFPQ-ERELELVHRLDRDTSGLIMVA 156

Query: 65  LSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKGPQP 124
                 R L +  +  QI+KRY  + +G+  +E  LD PL++ ++   ++  R  +  +P
Sbjct: 157 RRRSFLRKLQRLMQGGQIEKRYWLLCQGFKGKERTLDAPLLKMMNG-NERIVRVSREGKP 215

Query: 125 AVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHGDL 184
           +VTH+R L                  LVE   +TGR HQ+R H       ++GDSK+G  
Sbjct: 216 SVTHFRLLERFAQAQ-----------LVEATLETGRTHQIRVHSQFGGFALLGDSKYGIA 264

Query: 185 RQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           +     AE  G +RL LHA  L   HP TG+ LT+ A LDD +   L+  
Sbjct: 265 KGEALLAE-IGRRRLCLHARTLVFVHPNTGKRLTVTAPLDDDYEAILTAL 313


>UniRef50_A3Y8C6 Pseudouridine synthase n=1 Tax=Marinomonas sp. MED121
           RepID=A3Y8C6_9GAMM
          Length = 322

 Score =  245 bits (626), Expect = 1e-63,   Method: Composition-based stats.
 Identities = 71/232 (30%), Positives = 118/232 (50%), Gaps = 17/232 (7%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLM 63
           I+Y+D  L+ VNKPSG  VH         V V++ +R +  + +   HRLDR TSG++++
Sbjct: 100 IVYEDAGLMVVNKPSGLAVHGGSGLNFGLVEVVRQLRSK-EKSIELVHRLDRDTSGLIMI 158

Query: 64  GLSSEAGRLLAQQFEQHQ-IQKRYHAIVRG-WLMEEAVLDYPLVEELDKIADKFAREDKG 121
                  + L     + + +QK Y A+V G W   +  ++ PL++   K  ++  +    
Sbjct: 159 SKKRSVLKQLHAALREKEGVQKTYQALVYGSWPKRKQQVNAPLLKNELKSGERIVKVHTE 218

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
            + ++T ++ L   E            Y LVE EP TGR HQ+R H  H  +PI+GD K+
Sbjct: 219 GKESLTRFKLLRQFE-----------GYSLVECEPVTGRTHQIRVHTLHAGYPIVGDDKY 267

Query: 182 GDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
               QN+  A+  G +RL LHA++L +      + + +   +DD W  A++Q
Sbjct: 268 SPSEQNKE-AKGLGFKRLCLHAAKLDIM--LNDQRILVEVPIDDEWRNAMNQ 316


>UniRef50_A4J479 Pseudouridine synthase n=1 Tax=Desulfotomaculum reducens MI-1
           RepID=A4J479_DESRM
          Length = 303

 Score =  245 bits (626), Expect = 1e-63,   Method: Composition-based stats.
 Identities = 71/236 (30%), Positives = 113/236 (47%), Gaps = 25/236 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKV---VVMQTVRDQIGQHVFTAHRLDRPTS 58
           L ILY+D  L+AVNKP G LVH    +    +   V+   ++          HRLDR TS
Sbjct: 84  LNILYEDAHLLAVNKPPGMLVHPLTNETSGTLANGVLYHWLQQGTIDRFRPVHRLDRNTS 143

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADKFAR 117
           G++L+  +    + L  Q +Q Q  +RY A+V+G +  E+ V+  P+  E      +   
Sbjct: 144 GIVLIARNPYVQQQLQIQMKQGQFVRRYLALVKGKVQPEQGVIQAPIALEEGSFIKRMI- 202

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
                + A++HY+ L T             +  LV +E +TGR HQ+R H+AH+ HP++G
Sbjct: 203 -SPAGKEAISHYQVLRTF-----------NQASLVRVELETGRTHQVRVHMAHMGHPLLG 250

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           DS +G    N        ++R  LH + L+  HP  G  + I   +     Q + +
Sbjct: 251 DSLYGGDTSN--------IKRQALHCAYLAFNHPVQGSRIKISCSVAGDIRQLMEE 298


>UniRef50_A6DMG7 tRNA pseudouridine synthase n=1 Tax=Lentisphaera araneosa HTCC2155
           RepID=A6DMG7_9BACT
          Length = 246

 Score =  244 bits (625), Expect = 2e-63,   Method: Composition-based stats.
 Identities = 103/241 (42%), Positives = 137/241 (56%), Gaps = 10/241 (4%)

Query: 5   LYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLMG 64
           LY+DE+LV   K +   VHRS + RD + ++        GQ+V+  HRLDRP SG LL  
Sbjct: 10  LYEDEYLVVAKKLAKISVHRSEMCRDRRTLLTMVRNKLGGQYVYAVHRLDRPVSGPLLFA 69

Query: 65  LSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKGPQP 124
            S E  R L +QF +  ++K+Y A+VRGWL  +  +D  L+++ +             Q 
Sbjct: 70  KSPEMCRELQKQFNEKTVEKKYIALVRGWLEGKGKVDKQLLKKSNGTI----------QD 119

Query: 125 AVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHGDL 184
            +T YRGLAT E+    G++PT RYGLVELEP TGR HQLRRH+  L +PIIGDS  GD 
Sbjct: 120 CLTRYRGLATAEIDEPLGKFPTVRYGLVELEPVTGRYHQLRRHMRDLAYPIIGDSTDGDS 179

Query: 185 RQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWRGLLPENE 244
            QNR   E F L+RLMLH   LS  HP + E + I+   D   ++   Q G      + E
Sbjct: 180 HQNRFFREKFELRRLMLHCFYLSFKHPVSQELIKIYLEPDRDLLRIYEQLGMYEQFKQLE 239

Query: 245 R 245
           R
Sbjct: 240 R 240


>UniRef50_B7GEZ0 Pseudouridine synthase n=7 Tax=Bacillaceae RepID=B7GEZ0_ANOFW
          Length = 315

 Score =  244 bits (625), Expect = 2e-63,   Method: Composition-based stats.
 Identities = 68/229 (29%), Positives = 108/229 (47%), Gaps = 25/229 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKV---VVMQTVRDQIGQHVFTAHRLDRPTS 58
           L I+++D+ ++ VNK +   VH +   +   +   V      + I   V   HRLDR TS
Sbjct: 96  LHIVFEDDHVLVVNKRAHMDVHPTQPGQTNTLANAVAFHFQCEGIYSKVRHIHRLDRDTS 155

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADKFAR 117
           GV+L    + AG +L Q   +  I++ Y A+V G++  ++  ++ P+  +      +  R
Sbjct: 156 GVILFAKHALAGAILDQYLAKRTIRRTYIALVHGYVKQKKGTIEAPIGRDRHHPTRR--R 213

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
             K    A+THY  L   +              LV L   TGR HQ+R H++++ HP++G
Sbjct: 214 VSKTGDTAITHYERLQYDKQK---------HVSLVRLTLDTGRTHQIRVHMSYIGHPLVG 264

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDT 226
           D+ +G             + R  LHA  LS  HPFT E +T  A L D 
Sbjct: 265 DTLYGGKPW---------IDRQALHAFSLSFLHPFTEELITCSA-LPDE 303


>UniRef50_Q2GGY1 Pseudouridine synthase n=13 Tax=Rickettsiales RepID=Q2GGY1_EHRCR
          Length = 337

 Score =  244 bits (625), Expect = 2e-63,   Method: Composition-based stats.
 Identities = 50/251 (19%), Positives = 101/251 (40%), Gaps = 24/251 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG-------QHVFTAHRLD 54
           + ++Y+D  ++ +NK  G  VH      +  +V                       HRLD
Sbjct: 96  ISVVYEDHDIIIINKAPGITVHPGAGTNNNTLVNALVAHYGNSLSHVGKATRPGIIHRLD 155

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIAD 113
           + TSG++++  + ++   L+    + QI+K Y A+V G    +   +   +  + +    
Sbjct: 156 KDTSGLMVIAKNEKSYYFLSDLLLKKQIKKEYLAVVWGLPNPKSNTIKNYICVKPNNKQM 215

Query: 114 KFARE-DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLR 172
                     + A+T Y+   +           +    L++    TGR HQ+R H++++ 
Sbjct: 216 MTVTHLPHKGKLAITEYQTQKSF----------SNIASLIKCRIHTGRTHQIRVHMSYIG 265

Query: 173 HPIIGDSKHGDL-----RQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTW 227
           + IIGD K+G       +  +       L+R  LHA +L  THP +   +  H+ + +  
Sbjct: 266 NSIIGDQKYGKNNSKSVKYAKQSTIINTLKRQALHAYKLGFTHPTSNTYIEFHSYIPNDI 325

Query: 228 MQALSQFGWRG 238
              + +     
Sbjct: 326 QMLIDELEQLS 336


>UniRef50_A2U235 Pseudouridine synthase n=3 Tax=Flavobacteriaceae RepID=A2U235_9FLAO
          Length = 234

 Score =  244 bits (624), Expect = 2e-63,   Method: Composition-based stats.
 Identities = 84/241 (34%), Positives = 133/241 (55%), Gaps = 12/241 (4%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRD--EKVVVMQTVRDQIGQHVFTAHRLDRPTSG 59
           LEI+Y+D +L+ V KP+  LVH ++  R+  ++  ++Q V ++ G  V+  HRLDR TSG
Sbjct: 3   LEIIYEDAYLLCVTKPNNVLVHHAYHSRNMADEKSLLQLVSEETGLKVYPIHRLDRKTSG 62

Query: 60  VLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARED 119
            +L+    E        F ++QIQK Y+ +VRG+      +D P+      +        
Sbjct: 63  AILLAKEKEYVAKFQDLFTKNQIQKIYYGVVRGFSPSTKRIDSPVKGRDANVH------- 115

Query: 120 KGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDS 179
              + A+T  + LA + + +A   Y ++RY L+EL PKTGR HQLR H   + HP+IGD+
Sbjct: 116 ---KEALTELKTLAKITLDIAVKPYDSSRYSLIELFPKTGRMHQLRVHSNKISHPLIGDA 172

Query: 180 KHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWRGL 239
           K+GD   +    ++FG + L LHA +L   HP+T E L + +     W+Q   +F W+  
Sbjct: 173 KYGDKNHDMMFEQNFGFKNLFLHAGKLEFIHPYTQETLILKSTFPTDWIQLFEKFNWKNP 232

Query: 240 L 240
           L
Sbjct: 233 L 233


>UniRef50_C7MN62 Pseudouridine synthase n=8 Tax=Coriobacteriaceae RepID=C7MN62_CRYCD
          Length = 347

 Score =  244 bits (624), Expect = 2e-63,   Method: Composition-based stats.
 Identities = 61/249 (24%), Positives = 99/249 (39%), Gaps = 22/249 (8%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRD--------QIGQHVFTAHRL 53
           L++ ++D W++A++K +G  VH +       +V               Q        HRL
Sbjct: 82  LDVRFEDRWMMAISKQAGLCVHPAPGHEGGTLVNALIYAYGRDSLAHVQGDDRPGIVHRL 141

Query: 54  DRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIA 112
           D  TSG+++       G  L      H++ +RY  +V G +  +   +D P+    D   
Sbjct: 142 DMDTSGLMMCAKDDTCGMALQDLVRDHKVDRRYLTLVHGNIAFDTGQIDEPIGRVGDDRL 201

Query: 113 DKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLR 172
                     + A+T +  L   E            Y L+E    TGR HQ+R H+  + 
Sbjct: 202 RMKISYRPTARNALTTFTVLERFE-----AGRADNGYTLLECRLYTGRTHQIRVHMEFIG 256

Query: 173 HPIIGDSKH--GDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQA 230
           H  +GD  +  G+ + N        L R  LH+  LS  HP TG+ + +  GL      A
Sbjct: 257 HCCVGDPLYRWGNEQVN------LELSRQFLHSYSLSFNHPMTGDDIALVDGLPPDLFGA 310

Query: 231 LSQFGWRGL 239
           L     R +
Sbjct: 311 LRSLEDRSM 319


>UniRef50_C0MA80 Pseudouridine synthase n=6 Tax=Streptococcus RepID=C0MA80_STRE4
          Length = 300

 Score =  243 bits (622), Expect = 3e-63,   Method: Composition-based stats.
 Identities = 70/239 (29%), Positives = 106/239 (44%), Gaps = 24/239 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTV---RDQIGQHVFTAHRLDRPTS 58
           L+I+Y+DE  + +NKP+G+    S +  +     ++     +D   + V    RLDR TS
Sbjct: 76  LDIVYEDEHFLILNKPAGYASIPSAIHSNTIANFIKAYYIKQDYPNKQVHIVTRLDRDTS 135

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGW--LMEEAVLDYPLVEELDKIADKFA 116
           G++L      A   L +Q +Q  I KRY+A+V G   L ++  +  P+    D I  +  
Sbjct: 136 GLMLFAKHGYAHARLDKQLQQRAINKRYYALVCGQERLPDQGEIIAPIGRTDDSIITRTV 195

Query: 117 REDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPII 176
                 + A T Y+ +A     V           LV++   TGR HQ+R H AHL  P++
Sbjct: 196 TPK--GKYAKTSYKVIARYPENV----------SLVDITLHTGRTHQIRVHFAHLGFPLL 243

Query: 177 GDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFG 235
           GD  +G       G    G+ R  LH   LS THPFT         L D +   +    
Sbjct: 244 GDDLYG-------GRLDLGMTRQALHCHHLSFTHPFTESRSDHTICLTDDFESVIIDLQ 295


>UniRef50_A8F4Z7 Pseudouridine synthase n=2 Tax=Thermotogaceae RepID=A8F4Z7_THELT
          Length = 294

 Score =  243 bits (622), Expect = 4e-63,   Method: Composition-based stats.
 Identities = 63/234 (26%), Positives = 106/234 (45%), Gaps = 28/234 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV-VMQTVRDQIGQHVFTAHRLDRPTSGV 60
           L+ILY+D+ L+ +NK +G  +H S   R   ++  +     + G      HRLDR TSGV
Sbjct: 86  LDILYEDDNLLILNKKAGITIHPSEKTRSTTLIQGLHFYGAKKGFKPHLVHRLDRDTSGV 145

Query: 61  LLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDK 120
           L++  + +  R L+  F    ++K Y  +V G +  +  +D PL                
Sbjct: 146 LVIAKNVKTARTLSHMFRNRLVKKEYITLVSGKIFGDGFIDKPL---------------- 189

Query: 121 GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSK 180
               A+T Y+ L                  L+ +   TGR HQ+R+H A + +P++GD  
Sbjct: 190 DGSEALTEYKVLENFR-----------DTSLLRVILHTGRTHQIRKHFALIGNPVVGDIL 238

Query: 181 HGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           +GD + N    +   L+R  LH  ++S T+P     ++I A L D   + +   
Sbjct: 239 YGDKKVNELFKKKHNLRRQFLHCIRISFTNPSEPGVISIKAPLPDDLERVIKGL 292


>UniRef50_D2RBY1 Pseudouridine synthase, RluA family n=1 Tax=Gardnerella vaginalis
           409-05 RepID=D2RBY1_GARVA
          Length = 321

 Score =  242 bits (620), Expect = 6e-63,   Method: Composition-based stats.
 Identities = 72/241 (29%), Positives = 119/241 (49%), Gaps = 24/241 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKV-VVMQTVRDQIGQHV------FTAHRLD 54
           + I+Y D+ +V ++KP G   H +       V   ++ V   I   +          RLD
Sbjct: 92  IPIIYNDDDVVVIDKPVGVASHAAKGWSGPTVPECLEAVGIDIKTTLCDESRKGIVSRLD 151

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIAD 113
             TSG++L+  +  A  ++  QF +H ++K YHA+V+G L ++ A +D P+     K++D
Sbjct: 152 VGTSGLMLVCKTDFAYEVMKNQFAKHIVKKTYHALVQGDLAQDKATIDAPIGR--AKVSD 209

Query: 114 KFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
                    +PAVTH+  L              ++  LV +  +TGR HQ+R H + + H
Sbjct: 210 FRFTITSDGKPAVTHWDVLERF-----------SQATLVSVNLETGRTHQIRVHFSSIGH 258

Query: 174 PIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           P++GDS +G    N   A+  GLQR  LH+ +L+ THP TG+ +T+ +        AL  
Sbjct: 259 PLVGDSMYG---ANPVLAQKLGLQRQWLHSMELTFTHPRTGKSVTVKSHYPLDLQHALEA 315

Query: 234 F 234
            
Sbjct: 316 M 316


>UniRef50_A5INM9 Pseudouridine synthase n=7 Tax=Thermotogaceae RepID=A5INM9_THEP1
          Length = 304

 Score =  242 bits (619), Expect = 8e-63,   Method: Composition-based stats.
 Identities = 64/238 (26%), Positives = 108/238 (45%), Gaps = 28/238 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV-VMQTVRDQIGQHVFTAHRLDRPTSGV 60
           L++LY+ +  + +NKP    +H         ++  +     + G   F  HRLD+ TSG+
Sbjct: 85  LDVLYEGKHYLVLNKPPNIAIHPGKGVHVATLIEGLLHYGQEKGFSPFLVHRLDKDTSGL 144

Query: 61  LLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDK 120
           L++    EA R+L + F+   I+K Y  +VRG       +  PL                
Sbjct: 145 LVVAKDREAARILTELFKDRNIEKEYVTLVRGTPENNMKITIPL---------------- 188

Query: 121 GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSK 180
             Q A++    + ++               L+ ++  TGRKHQ+RRHL+ +  P++GD  
Sbjct: 189 DGQEAISEIVSVKSLR-----------DVSLLRVKIHTGRKHQIRRHLSQIGFPVVGDDT 237

Query: 181 HGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWRG 238
           +GD   NR   + +GL+RL LH+ ++    P+T E     A L D  +  L+    R 
Sbjct: 238 YGDRHFNREFRKRYGLKRLFLHSYRMKFIDPWTEEEKDFRAPLPDDLLSVLNFLEERS 295


>UniRef50_Q1Q689 Similar to ribosomal large subunit pseudouridine synthase D n=1
           Tax=Candidatus Kuenenia stuttgartiensis
           RepID=Q1Q689_9BACT
          Length = 335

 Score =  242 bits (619), Expect = 8e-63,   Method: Composition-based stats.
 Identities = 63/249 (25%), Positives = 107/249 (42%), Gaps = 28/249 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVM-----QTVRDQIGQ-HVFTAHRLDR 55
           L I+Y+D++L+ +NKP   +VH +       +V       Q +    G       HRLDR
Sbjct: 91  LNIIYEDDYLMLINKPYDMVVHPAGGHPSGTLVNAVTFYCQNLSQINGPLKAGIVHRLDR 150

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADK 114
            TSGV+L+  S      +A QFE+  ++K Y A+V G +  +   ++ P+         K
Sbjct: 151 DTSGVMLVIKSDAVHSHIAMQFEKRLVKKEYFAVVEGEVAFDSNEINMPIGRHRVD-RQK 209

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
            A      + A + Y  +                Y LV++ PKTGR HQ+R H+  + HP
Sbjct: 210 MAVRRDTGKNATSVYEVIERFR-----------GYTLVKIMPKTGRTHQIRVHMQAIGHP 258

Query: 175 IIGDSKHGD---------LRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDD 225
           ++ D  +           L + R+  E   ++R  LHA ++   HP   + +     + +
Sbjct: 259 VVADEMYSKYNACFRSDLLGKERAPDEGSIIERQALHAHRIEFFHPILNKQMAFQVDMAE 318

Query: 226 TWMQALSQF 234
                +S  
Sbjct: 319 DISFLVSAL 327


>UniRef50_Q28US1 Pseudouridine synthase n=43 Tax=Rhodobacterales RepID=Q28US1_JANSC
          Length = 354

 Score =  242 bits (618), Expect = 9e-63,   Method: Composition-based stats.
 Identities = 70/251 (27%), Positives = 103/251 (41%), Gaps = 28/251 (11%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLM 63
           ++Y+D+ ++A+NKP+G               + + ++  +       HRLD+ TSGVLLM
Sbjct: 99  VIYRDDHIIAINKPAGLPTQGGTGQSRHVDGLAEALKFGLEDKPRLVHRLDKDTSGVLLM 158

Query: 64  GLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIA------DKFA 116
             +    + L   F     +K Y A V G        +   LV+             +  
Sbjct: 159 ARTRMGAKALTDAFRLRSTRKIYWAAVAGSPLPRMGTIKLGLVKAPGHGRGGENEKMRAV 218

Query: 117 REDK-----GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHL 171
             D+     G + A T Y  ++ +            R     L P TGR HQLR H+A +
Sbjct: 219 PVDEIAQVDGAKRAETDYAVMSNL----------GGRVCWCALVPITGRTHQLRAHMAEI 268

Query: 172 RHPIIGDSKHGDLRQNRSG---AEHFG--LQR-LMLHASQLSLTHPFTGEPLTIHAGLDD 225
            HPIIGD K+G   Q   G       G  + R L LHA  LS  HP TG  + + A L +
Sbjct: 269 GHPIIGDGKYGGSGQENLGDGWGAQLGGEISRKLHLHARSLSFRHPMTGAQVNLVAPLPE 328

Query: 226 TWMQALSQFGW 236
              +     GW
Sbjct: 329 HMAKTWDTLGW 339


>UniRef50_B8DF66 Pseudouridine synthase n=18 Tax=Listeria RepID=B8DF66_LISMH
          Length = 289

 Score =  242 bits (618), Expect = 1e-62,   Method: Composition-based stats.
 Identities = 73/231 (31%), Positives = 112/231 (48%), Gaps = 24/231 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV-VMQTVRDQIGQ--HVFTAHRLDRPTS 58
           LEI+Y+D++L+ VNKP     H +     +     +Q   ++ GQ  +    HRLD+ TS
Sbjct: 78  LEIIYEDDFLLVVNKPVDMKTHANDSYETDTCANAVQYYLEKTGQDANALAVHRLDQTTS 137

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRG-WLMEEAVLDYPLVEELDKIADKFAR 117
           G++L   +  A   L+ Q E   I + Y A V G W +    ++ P+ E+    + +  +
Sbjct: 138 GLVLFAKNKLAIAGLSWQMENRAIHRTYLAAVDGTWGLVMQTINKPIGEDRHHGSRR--Q 195

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
                QPAVTH + L                  LVE + +TGR HQ+R HL+ + HPIIG
Sbjct: 196 ISPYGQPAVTHVKVLENDNEKNT---------SLVECQIETGRTHQIRVHLSGIGHPIIG 246

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWM 228
           D+ +G   +           R+MLHA +L L HPF G+ +   A   D W+
Sbjct: 247 DTLYGGSPR---------ANRIMLHAEKLHLNHPFKGKEMNFSAPAGDDWV 288


>UniRef50_C7GZW0 Pseudouridine synthase n=1 Tax=Eubacterium saphenum ATCC 49989
           RepID=C7GZW0_9FIRM
          Length = 318

 Score =  241 bits (617), Expect = 1e-62,   Method: Composition-based stats.
 Identities = 58/240 (24%), Positives = 111/240 (46%), Gaps = 27/240 (11%)

Query: 2   LEI--LYQDEWLVAVNKPSGWLVHRSWLDRDEKVV-VMQTVRDQIGQ--HVFTAHRLDRP 56
           +EI  +Y+DE L+ ++KP+G +VH +    +  +   +    D +G+   +   +RLD  
Sbjct: 94  IEINAVYEDEHLLVIDKPAGIVVHPTHGYEENTIAHALIHYMDTVGEEFKIRFINRLDMD 153

Query: 57  TSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADKF 115
           T+G+L++  +      +  + ++  ++KRY A+V G     E ++D P+     +   + 
Sbjct: 154 TTGLLMIAKNQFIQNAVVSEMKRGNVEKRYLAVVHGLPCNREGIIDAPIKAVEGEPRRQV 213

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
               +G +P++T Y+ +         G         +++   TGR HQ+R HL H+  PI
Sbjct: 214 M---EGGKPSITEYKVV---------GVSDELNVSFLDVRLHTGRTHQIRVHLKHIGCPI 261

Query: 176 IGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFG 235
           +GD  +G               R +LH+  L  THP + + + + A L D     L+   
Sbjct: 262 LGDEFYGGKES---------ADRQLLHSRYLRFTHPVSKKIVELTANLPDDIASILTHMQ 312


>UniRef50_B1YJB1 Pseudouridine synthase n=1 Tax=Exiguobacterium sibiricum 255-15
           RepID=B1YJB1_EXIS2
          Length = 293

 Score =  241 bits (617), Expect = 1e-62,   Method: Composition-based stats.
 Identities = 69/229 (30%), Positives = 113/229 (49%), Gaps = 22/229 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKV---VVMQTVRDQIGQHVFTAHRLDRPTS 58
           L+IL++D+WL+ VNKP G     S L  +  +   V+    + QI   +   +RLDR TS
Sbjct: 81  LDILFEDDWLLIVNKPPGMASIPSRLHPERSLSNFVLGYYRQHQIPYAIHIVNRLDRDTS 140

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           G+++    S A   L++  +   + +RY A++ G +  +  +D P+ +      ++  RE
Sbjct: 141 GLVVFAKHSLAHHQLSKMQQNGLLDRRYVALIEGTIPAQ-TIDLPIGQTDHSFMERMVRE 199

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
           D   Q A+TH   + T E   A  R        + ++ +TGR HQ+R HLA L HP++GD
Sbjct: 200 D--GQQAITH---ILTSEPITAFSR----ELSRLTIKLETGRTHQIRVHLAALGHPLVGD 250

Query: 179 SKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTW 227
           + +              + R  LH++  +  HP TGE +T  A L D  
Sbjct: 251 TMY---------KGTPLIARQALHSASATFPHPGTGEVMTFVAPLPDDL 290


>UniRef50_B4U613 Pseudouridine synthase, RluA family n=1 Tax=Hydrogenobaculum sp.
           Y04AAS1 RepID=B4U613_HYDS0
          Length = 308

 Score =  241 bits (617), Expect = 2e-62,   Method: Composition-based stats.
 Identities = 58/242 (23%), Positives = 103/242 (42%), Gaps = 21/242 (8%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG------QHVFTAHRLDR 55
           ++ILY+D  L  V KPSG   H      +  +V     +          +     HRLDR
Sbjct: 79  IDILYEDNDLAVVVKPSGMPSHTGPGHDENTLVNALLAKFGDLSVIGGVERPGIVHRLDR 138

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADK 114
            T G++++  +  + + L+  F+  ++ K Y AIV G    +E  ++  +          
Sbjct: 139 YTHGLMVIAKNDVSHQKLSLMFKNKEVDKHYKAIVYGISRFKEQTIETFIRRHPTNRLK- 197

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
                   + A+T Y           +   P     L++++  TGR HQ+R H++++ HP
Sbjct: 198 -FEVANEGKLAITKY-----------SLEKPLKNASLLDIKIYTGRTHQIRVHMSYIGHP 245

Query: 175 IIGDSKHG-DLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           I+GD+ +G          EH   +R +L A +LS  HP + +P+     + D +   L  
Sbjct: 246 IVGDTLYGYKHSYFDKTLEHMIGKRFLLVAYKLSFLHPKSQKPMEFEIDMPDYFKNVLKY 305

Query: 234 FG 235
             
Sbjct: 306 LE 307


>UniRef50_P59838 Ribosomal large subunit pseudouridine synthase D n=3
           Tax=Gammaproteobacteria RepID=RLUD_BLOFL
          Length = 321

 Score =  241 bits (617), Expect = 2e-62,   Method: Composition-based stats.
 Identities = 62/246 (25%), Positives = 105/246 (42%), Gaps = 26/246 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRD----QIGQHVFTAHRLDRPT 57
           L I+Y+D  ++ +NK S  +VH         V+     R     +I +      RLD+ T
Sbjct: 86  LNIIYEDNDILVINKASNMVVHPGIGHYQGTVLNALLYRYPSILKISKQAGIVQRLDKDT 145

Query: 58  SGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADKFA 116
           +G++++  +  A   L + F+  ++ K Y AIV G       V++ P+     K    F 
Sbjct: 146 TGLMIIAKTVSAYDNLLRSFKLRKVVKEYDAIVYGKFTSNAGVVNQPMRRHFAK--RTFM 203

Query: 117 REDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPII 176
                 + AVT+Y  +   +            +  V +  KTGR HQ+R H+A++ HP++
Sbjct: 204 SVHYTGKSAVTYYSVVEEFKA-----------HSRVRINLKTGRTHQIRVHMAYINHPLV 252

Query: 177 GDSKH-GDLR-------QNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWM 228
           GD K+ G+          +          R  LHA  L L HP T   +  +A L    +
Sbjct: 253 GDQKYKGNFSVFDIKKMSDELNNYLLDFNRQALHACTLQLLHPITQVQMKWNAPLPQDIL 312

Query: 229 QALSQF 234
           Q ++  
Sbjct: 313 QLIAIL 318


>UniRef50_Q0F3G2 Possible pseudouridine synthase n=1 Tax=Mariprofundus ferrooxydans
           PV-1 RepID=Q0F3G2_9PROT
          Length = 325

 Score =  241 bits (616), Expect = 2e-62,   Method: Composition-based stats.
 Identities = 65/239 (27%), Positives = 106/239 (44%), Gaps = 26/239 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV--VMQTVRDQIG----QHVFTAHRLDR 55
           L+IL++DE L+ +NKP+G +VH S       +V  ++   +   G    +     HRLD+
Sbjct: 88  LDILFEDEHLIVLNKPAGIVVHPSHGHDHGTLVHALLHHCKTLPGINGVERPGIVHRLDK 147

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADK 114
            TSG L++  S    + L++ F +H + ++Y A  RG        ++ P+         K
Sbjct: 148 DTSGSLVIAKSEVVHQRLSEMFAEHNLNRQYIAWCRGVPSWRVKCIELPIGRHP-HQRQK 206

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
            A  D G + ++T            A   +    +  + L   TGR HQ+R H+AH   P
Sbjct: 207 MAVTDSG-RESITD-----------AAVEHIFGPFSQMRLTLHTGRTHQIRVHMAHENLP 254

Query: 175 IIGDSKH------GDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTW 227
           ++GD  +      G      +      L R  LHA  L   HP +GEP++  A L +  
Sbjct: 255 VLGDPVYARSYHPGREIPEPARHAIATLSRQALHAELLEFDHPISGEPMSFRAPLPEDL 313


>UniRef50_B7BE87 Pseudouridine synthase n=8 Tax=Bacteroidales RepID=B7BE87_9PORP
          Length = 551

 Score =  241 bits (615), Expect = 2e-62,   Method: Composition-based stats.
 Identities = 79/230 (34%), Positives = 106/230 (46%), Gaps = 23/230 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           LEI+Y+DE L+ VNKP+G L      D D     ++ +           HRLD  TSG++
Sbjct: 337 LEIVYEDESLLVVNKPAGMLSVPGKSDVDSVYQRVRRMYPG-ATGPMVVHRLDMATSGLM 395

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADKFAREDK 120
           L+  + E  + L  QF+   + KRY A + G + E E  L+ PL  + +    +      
Sbjct: 396 LVAKTKEVHQNLQAQFKNRTVCKRYVAWLDGIVEEKEGHLELPLRPDPEDRPRQVVDVVH 455

Query: 121 GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAH---LRHPIIG 177
           G +PAVT YR L            P     +V   PKTGR HQLR H AH   L  PI+G
Sbjct: 456 G-KPAVTDYRVLRYGGCKGGLRTTP----TVVSFVPKTGRTHQLRVHSAHPLGLNAPIVG 510

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTI--HAGLDD 225
           D  +G               RL LHA  L  THP +G  + +   AG DD
Sbjct: 511 DELYGKK-----------ADRLYLHAEYLGFTHPVSGVYMEVEKEAGFDD 549


>UniRef50_Q83G23 Pseudouridine synthase n=2 Tax=Tropheryma whipplei
           RepID=Q83G23_TROWT
          Length = 303

 Score =  241 bits (615), Expect = 2e-62,   Method: Composition-based stats.
 Identities = 68/238 (28%), Positives = 109/238 (45%), Gaps = 20/238 (8%)

Query: 1   MLEILYQDEWLVAVNKPSGWLVH--RSWLDRDEKVVVMQTVRD-QIGQHVFTAHRLDRPT 57
           +L ++Y D+ L  ++KP+G   H    W        +   +            HRLD  T
Sbjct: 75  LLRVIYSDDDLFVIDKPAGVAAHASPGWCGPTVTGCLSGLLAACGPQDRQGIVHRLDANT 134

Query: 58  SGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADKFA 116
           SG++++  S  A   L   F    I KRY A+V+G+      V++ P+  +L K  D+F 
Sbjct: 135 SGLMVLAKSDLAYHNLKAAFRDRAIHKRYKALVQGYPDPSSGVINAPIGRDL-KHRDRF- 192

Query: 117 REDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPII 176
             D   + AVT Y                   + L+ + PKTGR HQ+R H + LRHP++
Sbjct: 193 CIDYSGRDAVTQYSTEEVY-----------PGFTLLSVAPKTGRTHQIRVHFSALRHPLV 241

Query: 177 GDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           GD K+G    +   ++   L+R  LHA  LS THP +G  +   + + +   ++L   
Sbjct: 242 GDVKYG---ADPVFSQKVNLKRQWLHAYHLSFTHPVSGVFVEFESRIHEDLQESLRIL 296


>UniRef50_D0MK65 Pseudouridine synthase n=1 Tax=Rhodothermus marinus DSM 4252
           RepID=D0MK65_RHOM4
          Length = 235

 Score =  241 bits (615), Expect = 2e-62,   Method: Composition-based stats.
 Identities = 76/235 (32%), Positives = 117/235 (49%), Gaps = 25/235 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRD-EKVVVMQTVRDQIGQHVFTAHRLDRPTSGV 60
           L ILY+D+ L+AV+KP G        +RD  +    + +    G+ ++  HRLD+  SGV
Sbjct: 3   LPILYEDDDLLAVHKPEGLAAIP---ERDPSRPSARRLLEAARGERLWVVHRLDKEASGV 59

Query: 61  LLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADKFARED 119
           LL   ++EA R +   FEQ Q++K Y A+V G L   +  +  P+       + +   + 
Sbjct: 60  LLFARNAEAHRYMNTLFEQRQVRKVYRALVHGRLEPGQGQIRAPIR---MYGSGRMGVDP 116

Query: 120 KGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDS 179
           +  +P+ T YR L           Y    Y L+E  P TGR+HQ+R H  H+ HPI+GD 
Sbjct: 117 ERGKPSETRYRVLE----------YLDEAYSLIEALPLTGRRHQIRVHCYHIGHPIVGDP 166

Query: 180 KHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           ++GD    +         RLMLHA  +   HP  G+ L I A + +++ Q L   
Sbjct: 167 RYGDRSVQQR------YPRLMLHALSIRFRHP-NGQELEIVAPVPESFQQVLDAL 214


>UniRef50_A1WTN6 Pseudouridine synthase n=2 Tax=Ectothiorhodospiraceae
           RepID=A1WTN6_HALHL
          Length = 249

 Score =  241 bits (615), Expect = 3e-62,   Method: Composition-based stats.
 Identities = 108/245 (44%), Positives = 145/245 (59%), Gaps = 10/245 (4%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQH-VFTAHRLDRPTSGV 60
           L ILY+DE L+AV KP+G LVHRS +DRD + VV+Q +RDQ+G H V+  HRLDR T+GV
Sbjct: 11  LAILYRDERLIAVYKPAGLLVHRSNIDRD-RDVVLQRLRDQLGGHWVYPVHRLDRATAGV 69

Query: 61  LLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDK 120
           L+ GL  +A  +LA  F + +I KRY A+VRGW+     +D PL                
Sbjct: 70  LVFGLDPDAASVLAAAFREQRIGKRYQAVVRGWVEAPGRIDRPLGAGRRGEGGA------ 123

Query: 121 GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSK 180
            PQPAVT Y  LA  E+P+   RY T R+  + L P+TGR+HQLRRH+  + HPI+GD+ 
Sbjct: 124 -PQPAVTDYVPLAWTELPIPVSRYDTARFTRLALHPQTGRQHQLRRHMKAISHPILGDTT 182

Query: 181 HGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGW-RGL 239
           HGD   NR   EHFG +RL+L A++L + HP  G  + +    D        + G     
Sbjct: 183 HGDGANNRFFREHFGARRLLLVATELVVPHPADGGAVRLATEPDAELQAIFRRAGLGEAP 242

Query: 240 LPENE 244
            P +E
Sbjct: 243 SPADE 247


>UniRef50_D2M2K8 Pseudouridine synthase, RluA family n=1 Tax=Bacillus
           cellulosilyticus DSM 2522 RepID=D2M2K8_BACS4
          Length = 298

 Score =  240 bits (614), Expect = 3e-62,   Method: Composition-based stats.
 Identities = 58/237 (24%), Positives = 112/237 (47%), Gaps = 25/237 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKV---VVMQTVRDQIGQHVFTAHRLDRPTS 58
           L I+++DE ++ +NKP       +  + +  +   ++   + + I        RLDR TS
Sbjct: 83  LHIIFEDEHVIIINKPPHLPTIPTRNEGEPSLAGAILAYYIENGIPSTFHAVSRLDRDTS 142

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADKFAR 117
           G++++        L  +  + ++I++ Y A+V G L ++   +D P+  +   I ++   
Sbjct: 143 GLVMVAKHRYMHDLCVKLQKSYEIKRSYVALVEGILSDDYNTIDLPISRKTTSIIEREV- 201

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
            ++  + A+THY  L              +   L++L  +TGR HQ+R H++ + HP++G
Sbjct: 202 -NEFGKSAITHYEVLKRY-----------SGATLLQLTLETGRTHQIRVHMSAIGHPLLG 249

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           D+ +G         +   + R  LH+ QLS  HP      T H  + D    A+S+F
Sbjct: 250 DTLYGG--------DVRYIDRQALHSHQLSFFHPINKREYTFHCPIPDDIEDAMSKF 298


>UniRef50_C2W5F3 Pseudouridine synthase n=4 Tax=Bacillus RepID=C2W5F3_BACCE
          Length = 307

 Score =  240 bits (614), Expect = 3e-62,   Method: Composition-based stats.
 Identities = 59/237 (24%), Positives = 106/237 (44%), Gaps = 23/237 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKV---VVMQTVRDQIGQHVFTAHRLDRPTS 58
           LE++++D+ ++ VNKP+    H S       +   V        +   V   HRLD+ T+
Sbjct: 85  LEVIFEDDHVLIVNKPAHMDTHPSNKGGTGTLANLVAFHLQMQGVETKVRHIHRLDKDTT 144

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADKFAR 117
           G ++      AG ++ +   +  I++ Y A+V G +  ++ ++D  +  +      +  R
Sbjct: 145 GGVVFAKHGIAGVIMDRLLMERNIKRTYLALVEGKVRKKQGIIDEAIGRDRHHATRR--R 202

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
             +    AVTHY+             +      LV L+ +TGR HQ+R H++H  HP+IG
Sbjct: 203 VSQKGDRAVTHYKIEKY---------FKKQDVTLVTLQLETGRTHQIRVHMSHSGHPLIG 253

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           D  +G         +   +    LHA ++   HP T E +T+ A L +     +  F
Sbjct: 254 DVLYGG--------QATYMPYQALHAMRIHFLHPITKEEITVEAPLPNNLNNIIESF 302


>UniRef50_C1ZB48 Pseudouridine synthase, RluA family n=1 Tax=Planctomyces
           limnophilus DSM 3776 RepID=C1ZB48_PLALI
          Length = 325

 Score =  240 bits (614), Expect = 3e-62,   Method: Composition-based stats.
 Identities = 76/254 (29%), Positives = 120/254 (47%), Gaps = 30/254 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV-VMQTVRDQIG-----QHVFTAHRLDR 55
           LEIL++D+ L+ +NKP+G + H +    D  ++  +Q   D+       +     HRLDR
Sbjct: 82  LEILFEDDSLLVINKPAGLIAHPTGEIPDGTLINAVQHYLDKQSTHPGLERPGIVHRLDR 141

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEA-VLDYPLVEELDKIADK 114
            TSG + +     + RLL+ QF+  +I K Y A+V G L ++  V+D P+       +  
Sbjct: 142 DTSGAMAICKEHLSHRLLSIQFQLGRISKSYLALVEGVLTDDQLVIDLPIGRAPGCSSAL 201

Query: 115 FAREDKG--PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLR 172
            +        Q + T  R +               ++ LVE +P+TGR HQ+R HLA + 
Sbjct: 202 MSCRADALEAQASKTSLRVVERF-----------PQHTLVEAKPRTGRMHQIRIHLATIG 250

Query: 173 HPIIGDSKH---GDLR-----QNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLD 224
            PI+GD  +   G++R     ++        + R  LHA+ LS  HP T E     A L 
Sbjct: 251 FPIVGDEFYLKGGEIRPLVWPESERVQVSLLINRQALHAACLSFAHPLTNEWQDFQAPLP 310

Query: 225 DTWMQA--LSQFGW 236
           D   QA  L++ G 
Sbjct: 311 DDLRQAIELARLGQ 324


>UniRef50_B1XXM0 Pseudouridine synthase n=6 Tax=Burkholderiales RepID=B1XXM0_LEPCP
          Length = 369

 Score =  240 bits (614), Expect = 3e-62,   Method: Composition-based stats.
 Identities = 68/229 (29%), Positives = 105/229 (45%), Gaps = 19/229 (8%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVV---MQTVRDQIGQHVFTAHRLDRPTS 58
           L ++++D  L+ ++KP+G +VH +       ++                   HRLD+ TS
Sbjct: 119 LAVVHEDAHLLVIDKPAGLVVHPAAGHWSGTLLNGLLAHHAAAAHLPRAGIVHRLDKDTS 178

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADKFAR 117
           G++L+  S +A   L +      +++ Y A+V G +M+   V+D PL  +          
Sbjct: 179 GLMLVAKSLQAHTALVRAIAARDVKREYLALVHGAVMDGLQVIDAPLGRDPVSRVRMAIV 238

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGR------YPTTRYGLVELEPKTGRKHQLRRHLAHL 171
                +PA T  R LA  E+P    R          +   V  +  TGR HQ+R HLA  
Sbjct: 239 --ASGKPARTDVRRLAVAELPGDGVRQLPGATRAPRQVSAVHCQLHTGRTHQIRVHLASR 296

Query: 172 RHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIH 220
            HP++ D+ +G       GA  FGLQR  LHA++L L HP  G PL   
Sbjct: 297 GHPLLADAMYG-------GAPAFGLQRQALHAARLHLLHPIDGRPLAFE 338


>UniRef50_Q89AD9 Ribosomal large subunit pseudouridine synthase D n=1 Tax=Buchnera
           aphidicola (Baizongia pistaciae) RepID=RLUD_BUCBP
          Length = 317

 Score =  240 bits (614), Expect = 3e-62,   Method: Composition-based stats.
 Identities = 54/244 (22%), Positives = 108/244 (44%), Gaps = 22/244 (9%)

Query: 1   MLEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG---QHVFTAHRLDRPT 57
            L ++Y+D+ ++ +NK   ++VH    +    ++     RD            HRLD+ T
Sbjct: 84  FLNVIYEDDDILVINKQDNFVVHPGAGNTSGTLLNALLHRDSTFFNIPRAGIVHRLDKDT 143

Query: 58  SGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAR 117
           +G++++  ++ +   L  Q +  ++ + Y AIV G ++    +   ++    K       
Sbjct: 144 TGLMVIAKNNLSYMALIDQIKCKKVIREYQAIVYGKVISGGTIVKSIIRNPIKRTTMIV- 202

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
            +K  + A+THYR L              T +  +++  +TGR HQ+R H+ ++  P++G
Sbjct: 203 -NKCGKRAITHYRILKRF-----------THHTHLKIILETGRTHQIRTHMLYINFPLVG 250

Query: 178 DSKHGDLRQNRSGAEHFGL------QRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
           D  +G+  +         L       R  LHAS+L L HP T   +  ++ L    +  +
Sbjct: 251 DKTYGNKFKFYKNISLTLLEQVKKFPRQALHASRLCLYHPVTKHLMEWNSTLPRDMLNLI 310

Query: 232 SQFG 235
           +   
Sbjct: 311 ALLN 314


>UniRef50_Q8ERS8 Pseudouridine synthase n=2 Tax=Bacillaceae RepID=Q8ERS8_OCEIH
          Length = 322

 Score =  240 bits (614), Expect = 4e-62,   Method: Composition-based stats.
 Identities = 62/237 (26%), Positives = 107/237 (45%), Gaps = 24/237 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAH---RLDRPTS 58
           L+I+Y+D + + VNKP+G     S   R   +    T   Q      T H   RLD  TS
Sbjct: 103 LDIIYEDAYCLVVNKPAGQACLPSMNHRHNTLANGLTYYYQKNSIPSTVHIVTRLDVNTS 162

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADKFAR 117
           G++L+  +     L ++  ++  I + Y AIV G +     ++D P+  +   I ++   
Sbjct: 163 GLVLVAKNQYVHSLFSRMQQEGNINRVYEAIVHGEVSPTSGIVDAPIARKEGSIIERTVD 222

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
             +  + A T+YR L           Y  +    VE++ +TGR HQ+R H  +L H + G
Sbjct: 223 M-RNGKYAKTNYRVL-----------YADSIASWVEIKLETGRTHQIRVHFQYLGHSLYG 270

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           D+ +G  +          + R  LH  Q+++ HP   +P+ + A L +     L + 
Sbjct: 271 DNLYGGSKD--------IMLRQALHCKQITMMHPIKNQPIQLEASLPEDMGILLKRL 319


>UniRef50_Q6MGX8 Pseudouridine synthase n=1 Tax=Bdellovibrio bacteriovorus
           RepID=Q6MGX8_BDEBA
          Length = 319

 Score =  240 bits (613), Expect = 4e-62,   Method: Composition-based stats.
 Identities = 60/261 (22%), Positives = 110/261 (42%), Gaps = 37/261 (14%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVR------DQIGQHVFTAHRLDR 55
           L++L++DE L+ +NKP+G +VH +     + +V                +     HRLD+
Sbjct: 69  LDVLFEDEDLIVINKPAGLVVHPAAGHAHDTLVNALIHHTDDLSMKFGEERPGIVHRLDK 128

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADK 114
            TSG++++  + +A   L  QF++    + Y+A+  G        +   L          
Sbjct: 129 ETSGIIVIAKNDKAHESLTSQFKERSTHRIYYAVCLGTARTLSGSVRSFLARHPVDRKRY 188

Query: 115 FAREDKGPQP-------------AVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRK 161
            +      +P             AVTH+  L              +    ++L+ +TGR 
Sbjct: 189 ASVLGDDRKPLTDPNDDPGLGKWAVTHFEVLQR-----------KSGMSYLKLKLETGRT 237

Query: 162 HQLRRHLAHLRHPIIGDSKHGDLRQNRS------GAEHFGLQRLMLHASQLSLTHPFTGE 215
           HQ+R H++    PI GD+ +G  R+ +S        +   L R +LHA++L  THP T E
Sbjct: 238 HQIRVHMSESGLPIAGDTLYGADRKIKSIEARATQEDLRTLPRFLLHAAELGFTHPRTKE 297

Query: 216 PLTIHAGLDDTWMQALSQFGW 236
            +       +  +  + ++G 
Sbjct: 298 RMFFTKDWPEDVLVLIKKWGL 318


>UniRef50_Q2RQY9 Pseudouridine synthase n=3 Tax=Alphaproteobacteria
           RepID=Q2RQY9_RHORT
          Length = 330

 Score =  240 bits (613), Expect = 5e-62,   Method: Composition-based stats.
 Identities = 68/234 (29%), Positives = 106/234 (45%), Gaps = 15/234 (6%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLM 63
           IL++D  L+ +NK +G  V            +++++ D  G+     HRLD+ TSGVL++
Sbjct: 96  ILHEDAHLIVINKEAGLAVQGGTGTPHHLDGMLESLADG-GETPRLVHRLDKDTSGVLVL 154

Query: 64  GLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADKFAREDKGP 122
             +  A R L   F   +  K Y AIV G     +  +   L +      ++    ++  
Sbjct: 155 ARTQAAARALTSAFRSREALKVYWAIVVGRPPMLQGTIKGALAKVAGGRGERMEINEEEG 214

Query: 123 QPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHG 182
           + AVT +R +                   VEL P+TGR HQLR H   +  PI+GD K+G
Sbjct: 215 KRAVTDFRVVDQAAKAC----------AWVELHPRTGRTHQLRVHCLEMGTPILGDGKYG 264

Query: 183 DLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGW 236
                  G E    +R+ LHA  L+L HP  G  L I A     ++++L   G+
Sbjct: 265 GPGAFLEGTELP--KRMHLHARALALPHPAGG-VLEIIAPPPPHFVESLKTLGF 315


>UniRef50_Q21K97 Pseudouridine synthase n=10 Tax=Gammaproteobacteria
           RepID=Q21K97_SACD2
          Length = 321

 Score =  239 bits (612), Expect = 5e-62,   Method: Composition-based stats.
 Identities = 66/225 (29%), Positives = 103/225 (45%), Gaps = 15/225 (6%)

Query: 12  VAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLMGLSSEAGR 71
           + VNKP+G  VH         +  ++    Q   ++   HRLDR TSG +L+       R
Sbjct: 99  LVVNKPAGLAVHGGSGVTLGLIEALRQAFPQYS-YLELVHRLDRDTSGCILVAKKRSMLR 157

Query: 72  LLAQQFE-QHQIQKRYHAIVRG-WLMEEAVLDYPLVEELDKIADKFAREDKGPQPAVTHY 129
            L + F  + +I KRY A+V G W     ++D PL+ +  +  ++  R     +P+ T +
Sbjct: 158 YLQELFRGEKRIHKRYLALVIGRWPSRRNLVDAPLLRKELQSGERIVRVSLDGKPSKTEF 217

Query: 130 RGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHGDLRQNRS 189
             +                  LVE  P TGR HQ+R H  H  HP++GD K+G+   + S
Sbjct: 218 NVVQRF----------GESATLVEARPITGRTHQIRVHAQHQGHPLVGDPKYGNEVFDLS 267

Query: 190 GAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
             +  G+ RL LHA+ LS  +   GE + I   L       ++ F
Sbjct: 268 -VKKLGVNRLFLHAAGLSFKN-ADGEQVNIEVPLPAELQSVVAAF 310


>UniRef50_C5WJF2 Pseudouridine synthase n=104 Tax=Lactobacillales RepID=C5WJF2_STRDG
          Length = 341

 Score =  239 bits (612), Expect = 5e-62,   Method: Composition-based stats.
 Identities = 67/238 (28%), Positives = 107/238 (44%), Gaps = 24/238 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           ++ LY+D+ L+ VNKP G   H    +   ++ ++  V    G+  +  HRLD  TSGV+
Sbjct: 127 VDCLYEDDHLIIVNKPEGMKTH---GNEPTELALLNHVSAYTGRTCYVVHRLDMETSGVI 183

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVL-DYPLVEELDKIADKFAREDK 120
           +   +     +L +  E+ +I + Y A+V G L  + V    P+         +     +
Sbjct: 184 VFAKTPFILPILNRLLEKREISRDYWALVHGTLSSKEVSYREPIGRHRHDRRKRVVDVKQ 243

Query: 121 GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSK 180
           G Q AVT  + L + +              L+    +TGR HQ+R HL+H  H ++GD  
Sbjct: 244 G-QKAVTDVKLLKSFK----------QNVSLINCRLQTGRTHQIRVHLSHHGHALLGDPL 292

Query: 181 HGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWRG 238
           +   +            RLMLHA QL L HP T E + + A    T+   L Q   +G
Sbjct: 293 YSKGKAE--------CPRLMLHAHQLRLRHPLTQEMICVQAK-STTFETVLQQVKAKG 341


>UniRef50_A4J1I1 Pseudouridine synthase n=1 Tax=Desulfotomaculum reducens MI-1
           RepID=A4J1I1_DESRM
          Length = 303

 Score =  239 bits (612), Expect = 6e-62,   Method: Composition-based stats.
 Identities = 66/238 (27%), Positives = 115/238 (48%), Gaps = 25/238 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKV---VVMQTVRDQIGQHVFTAHRLDRPTS 58
           L I+ +DE +  VNK  G  VH +       +   +V   + +         +R+DR TS
Sbjct: 83  LSIISEDEDIALVNKQPGMCVHPTLAYPSGTLANGLVYHWLENNPAPTFHAVNRIDRNTS 142

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADKFAR 117
           G++L+  +S + + L  Q ++ Q+ + Y A+V G +++    +D PL +   K   +  +
Sbjct: 143 GLVLVAKNSYSAQKLFLQRKRKQLARSYVALVHGKIVQRNGYIDLPLEKCEGKTTKR--Q 200

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
                Q A+T +  L  +           T   L+ L P+TGR HQ+R HL+HL HP++G
Sbjct: 201 ISSTGQQALTRFEVLQYI-----------TDCTLIRLMPETGRTHQIRVHLSHLGHPLVG 249

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFG 235
           D+ +G             + R  LHA ++S  HP TG P++    L +  +Q +++ G
Sbjct: 250 DTLYGGSIAQ--------IGRHCLHADKISFLHPRTGHPMSFQIPLAEDMLQVITEMG 299


>UniRef50_A5VJ18 Pseudouridine synthase, RluA family n=13 Tax=Lactobacillus
           RepID=A5VJ18_LACRD
          Length = 301

 Score =  239 bits (612), Expect = 6e-62,   Method: Composition-based stats.
 Identities = 60/239 (25%), Positives = 104/239 (43%), Gaps = 27/239 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVV-----MQTVRDQIGQHVFTAHRLDRP 56
           ++I+Y+D+  + +NKP+G     +        +V         ++   Q    A RLDR 
Sbjct: 78  IDIIYEDQDFLIMNKPAGVATVPAHNVPVADSLVNRVKGYYKRQNYENQVTHVATRLDRD 137

Query: 57  TSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADKF 115
           TSG+++      A  +L +Q ++H ++K Y A+++G +  E   +D P+  + +    + 
Sbjct: 138 TSGLVVFPKHRFAHAVLDEQLKKHLVKKNYLALIKGKVPAEHGYIDAPIQRDPNSFVKRM 197

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
               K  + +VT Y                  +  L+++   TGR HQ+R H A L  P+
Sbjct: 198 V--GKEGKASVTEYWRQEC-----------NVQASLIKIRLHTGRTHQIRVHFASLGFPL 244

Query: 176 IGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           IGD  +G         E   + R  LH   LS   PF G+ +T+ A L   +  A    
Sbjct: 245 IGDKMYG--------EESGLIARQALHCYWLSFYSPFKGKNITVSAPLPSDFKNAKDDL 295


>UniRef50_B0S119 Pseudouridine synthase n=2 Tax=Finegoldia magna RepID=B0S119_FINM2
          Length = 307

 Score =  239 bits (612), Expect = 6e-62,   Method: Composition-based stats.
 Identities = 56/238 (23%), Positives = 104/238 (43%), Gaps = 25/238 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHV------FTAHRLDR 55
           L+++Y+D++L  +NK    +VH +     + +V       +    V         HRLD+
Sbjct: 77  LDVVYEDDYLAIINKDKDVIVHPTETIYSDTLVNYLMYNFKNLSDVDGDYRRGIVHRLDK 136

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKF 115
            T+G++++   ++    L +  + H+I K Y  IV G + E   +   +           
Sbjct: 137 DTTGLIIIAKDNDTHLKLKEIIKNHEIIKTYLCIVHGKIDESGTIKEYMTRNPKDRKKMM 196

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
             ++   + +++ Y  L                Y LV+++ KTGR HQ+R H+ ++ HPI
Sbjct: 197 VSDE--GKLSISQYERLDY-----------NDDYSLVKVQIKTGRTHQIRVHMNYIHHPI 243

Query: 176 IGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           +GD  +G  +      E       +LHA  L   HP T E + +   L   +M A+ +
Sbjct: 244 LGDKLYGLKK------EKILFDSQVLHAYNLQFIHPQTHEKINVIGKLKPDFMTAIEK 295


>UniRef50_A5ZQM9 Putative uncharacterized protein n=1 Tax=Ruminococcus obeum ATCC
           29174 RepID=A5ZQM9_9FIRM
          Length = 334

 Score =  239 bits (611), Expect = 6e-62,   Method: Composition-based stats.
 Identities = 67/253 (26%), Positives = 115/253 (45%), Gaps = 39/253 (15%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKV---VVMQTVRDQIGQHVFTAHRLDRPTS 58
           L ILY+DE ++AVNKP+G L H + +   + +   V        +   +    RLD+ TS
Sbjct: 86  LCILYEDEDILAVNKPAGVLTHPAGMHYSDSLANQVAAYFQERNLSVCIRPIGRLDKETS 145

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEA-----VLDYPLVEELDKIAD 113
           G++L   +  A + L +Q E   ++K+Y A+V G L ++       +D+P+ +  +    
Sbjct: 146 GIVLFAKNQVAAQRLQEQRETGVLEKQYLALVDGNLPKDQDDIWHTIDFPIKKIGNHPLR 205

Query: 114 KFAREDKGPQP-----------------AVTHYRGLATVEMPVATGRYPTTRYGLVELEP 156
             A +                       AVTHY  L           Y T ++  ++L+ 
Sbjct: 206 MEAVKKSSSAENEKYIAHQLTDYINCFQAVTHYHVL-----------YSTDKWSAIKLKL 254

Query: 157 KTGRKHQLRRHLAHLRHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEP 216
            TGR HQ+R H+  + HP++GDS +     NR   E   + R  LHA ++ L  PF G  
Sbjct: 255 DTGRTHQIRVHMQAIGHPLLGDSIYNTSTMNR---EQCTIYRAALHAWKVRLRQPFNGRK 311

Query: 217 LTIHAGLDDTWMQ 229
           + +   + + + +
Sbjct: 312 IELEVPVPEDFKK 324


>UniRef50_C0EHV8 Putative uncharacterized protein n=1 Tax=Clostridium methylpentosum
           DSM 5476 RepID=C0EHV8_9CLOT
          Length = 299

 Score =  239 bits (611), Expect = 6e-62,   Method: Composition-based stats.
 Identities = 62/236 (26%), Positives = 104/236 (44%), Gaps = 24/236 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQH---VFTAHRLDRPTS 58
            +I Y+D+ L+ VNKP+G  VH S    ++ +      +    +        +RLDR TS
Sbjct: 80  FDIAYEDDDLLLVNKPAGTPVHPSPGHYEDSLANYSAWQYAQRREQLVFRPVNRLDRGTS 139

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADKFAR 117
           G+L +  ++ A   L+QQ      ++ Y+A+V G        +D P+      +  +  R
Sbjct: 140 GLLCVAKNAHAQARLSQQLHTGAFERIYYAVVCGAPSPAAGTIDLPIGRTPGSVLKR--R 197

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
            D     AVTHY  +                Y L+++  +TGR HQ+R H AHL  P+ G
Sbjct: 198 VDPQGARAVTHYETVRV-----------NGAYTLLKIRLETGRTHQIRVHFAHLGCPLFG 246

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           D  +G  R++        ++   LH+ ++ L HP +GE +     L       +  
Sbjct: 247 DFLYGTERRDV-------VEGHALHSGEIRLLHPISGEEIRCSVPLPAYMENLMDN 295


>UniRef50_D1W0M0 Pseudouridine synthase n=1 Tax=Prevotella timonensis CRIS 5C-B1
           RepID=D1W0M0_9BACT
          Length = 566

 Score =  239 bits (611), Expect = 7e-62,   Method: Composition-based stats.
 Identities = 78/236 (33%), Positives = 113/236 (47%), Gaps = 32/236 (13%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ--HVFTAHRLDRPTSG 59
           L ++Y+D+ L+ V+KP+G L       R ++  V   +R Q+     +F+ HRLD  TSG
Sbjct: 351 LHVVYEDDALIVVDKPAGILSVPG---RSQRPSVYSILRSQMPSSVELFSVHRLDMATSG 407

Query: 60  VLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADKFARE 118
           +L++  +S   R L +QF  H IQK Y AI+ G L + E V+  PL  +      +    
Sbjct: 408 LLILAKNSVVYRHLQRQFRTHHIQKEYIAILEGALSQREGVVTLPLRPDPFDRPRQVVDW 467

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAH---LRHPI 175
           + G + AVT YR L                   V L P+TGR HQLR H AH   L  PI
Sbjct: 468 EHGKK-AVTSYRVL-----------NVRHGKTWVALFPETGRTHQLRMHCAHAEGLNCPI 515

Query: 176 IGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
           +GD  +G               RL LHA+ ++  HP +G+ LT+HA     +    
Sbjct: 516 LGDPLYG-----------HHANRLYLHATSITFEHPISGQLLTLHAQPPADFQDVF 560


>UniRef50_B0TDX6 Pseudouridine synthase, rlua family n=1 Tax=Heliobacterium
           modesticaldum Ice1 RepID=B0TDX6_HELMI
          Length = 339

 Score =  239 bits (610), Expect = 9e-62,   Method: Composition-based stats.
 Identities = 65/255 (25%), Positives = 116/255 (45%), Gaps = 19/255 (7%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ-----HVFTAHRLDRP 56
           L++LY+D  L+ ++KP G  VH        +  +   V     +      V   HRLD+ 
Sbjct: 83  LKVLYEDADLLILDKPPGIEVHPPEQRARFRPTLAHGVAHYFAEKGIKARVRPLHRLDKD 142

Query: 57  TSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADKF 115
           T+G+ +   ++ A + L +Q     +Q+ Y AI+RG   E   V+D P+  + +    + 
Sbjct: 143 TTGICVFAKNAFAHQALDRQLRNGSLQRGYLAILRGLPAELVGVIDAPIGRDPEHHMRRM 202

Query: 116 AREDKGPQPAVTHYR---GLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLR 172
            R+D   + A+T YR    +    + +         + L E+  +TGR HQ+R H  HL 
Sbjct: 203 VRDD--GERAITRYRVTQVIEPSGLEMKGAAESEGHWALAEVILETGRTHQIRVHFRHLG 260

Query: 173 HPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALS 232
            P++GD  +G         +   + R  LH++ ++L  P +GE + + A L +   + L 
Sbjct: 261 TPLLGDRLYGG--------DSPRIDRQALHSAWVTLLQPRSGEAVKVTAELPEDMARLLG 312

Query: 233 QFGWRGLLPENERVE 247
                G   E+ + E
Sbjct: 313 GKANDGSKNEDRKTE 327


>UniRef50_Q0BUM2 Pseudouridine synthase n=12 Tax=Acetobacteraceae RepID=Q0BUM2_GRABC
          Length = 366

 Score =  239 bits (610), Expect = 1e-61,   Method: Composition-based stats.
 Identities = 83/264 (31%), Positives = 121/264 (45%), Gaps = 32/264 (12%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLM 63
           ILY+D+ L+ +NKPSG               ++  +R          HRLDR TSGV+++
Sbjct: 125 ILYKDDHLIVLNKPSGLPSQGGPGITRHLDGLLDGLRFGRDDRPRLVHRLDRDTSGVIVI 184

Query: 64  GLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADKF--AREDK 120
             S      LA  F   + +K Y A+V G  +  E  +D PL+ + D+        R+D+
Sbjct: 185 ARSPGVAAKLAALFRTRETEKVYWAVVAGRPVPVEGRIDRPLLRQNDRNEPVVLADRKDR 244

Query: 121 GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSK 180
               A+T YR L           +   +   +EL P TGR HQLR H A +  PI+GD +
Sbjct: 245 DKVTAITDYRTLD----------HAARKLAWLELRPLTGRMHQLRVHCAAMDAPILGDER 294

Query: 181 HG-----DLRQNRSGAEHFGL-QRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           +G     D R  R+ A   GL +RL LHA +LSL HP  G  L++ A L     +     
Sbjct: 295 YGSWRNTDERGVRNTALVEGLSRRLHLHARRLSLPHPAGG-MLSVEADLSPHMAETFETL 353

Query: 235 GWRGLLPENERVEFSAPSGQDGEI 258
           G            F+AP  ++G +
Sbjct: 354 G------------FTAPKAREGRL 365


>UniRef50_Q492Q1 Pseudouridine synthase n=2 Tax=Candidatus Blochmannia
           RepID=Q492Q1_BLOPB
          Length = 338

 Score =  239 bits (610), Expect = 1e-61,   Method: Composition-based stats.
 Identities = 73/243 (30%), Positives = 120/243 (49%), Gaps = 17/243 (6%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLM 63
           I+Y+D++L+A+NKP+G   H     +   +  ++ +R +  Q +   HRLDR TSGVLL+
Sbjct: 94  IIYEDDYLLALNKPTGVAAHGGSGLKFGVIEGLRALRPK-AQFLELVHRLDRETSGVLLV 152

Query: 64  GLSSEAGRLLAQQFEQHQIQKRYHAIVRG-WLMEEAVLDYPLVEELDKIADKFAR--EDK 120
                A   L +Q     ++K Y A+V G W +   ++  PL ++   +        + +
Sbjct: 153 AKRRTALVYLHEQLRLQNMKKEYLALVHGRWNVNLQIVSVPLFKKNTLLNSSRVVYIDSE 212

Query: 121 GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSK 180
             + + TH++     +               + ++P TGR HQ+R H  +  HPI+GD++
Sbjct: 213 NGKFSTTHFQIKEYFDNV----------ATFLAIKPITGRTHQIRVHTQYASHPIVGDNR 262

Query: 181 HGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWRGLL 240
           +GD + N    + FG  RL LHAS L   HP T +   IHA L  ++   L  F  R L 
Sbjct: 263 YGDYQSNTRF-KRFGFNRLFLHASILRFIHPKTKKKFHIHAPLGQSFHNCL--FFLRNLS 319

Query: 241 PEN 243
            +N
Sbjct: 320 IKN 322


>UniRef50_P0AA37 Ribosomal large subunit pseudouridine synthase A n=205
           Tax=Proteobacteria RepID=RLUA_ECOLI
          Length = 219

 Score =  238 bits (609), Expect = 1e-61,   Method: Composition-based stats.
 Identities = 77/224 (34%), Positives = 110/224 (49%), Gaps = 20/224 (8%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           L ILYQD+ ++ VNKPSG L     L+  +  V+ +  RD       + HRLD  TSGV+
Sbjct: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDY--PQAESVHRLDMATSGVI 71

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADKFAREDK 120
           ++ L+  A R L +QF + + +K+Y A V G     E ++D PL+ +      +    + 
Sbjct: 72  VVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYET 131

Query: 121 GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSK 180
           G +PA T Y  +           Y       V L+P TGR HQLR H+  L HPI+GD  
Sbjct: 132 G-KPAQTEYEVVE----------YAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRF 180

Query: 181 HGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLD 224
           +       S        RL+LHA  L++THP  G  +T  A  D
Sbjct: 181 Y------ASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218


>UniRef50_B5ZBC1 RluA n=15 Tax=Ureaplasma RepID=B5ZBC1_UREU1
          Length = 299

 Score =  238 bits (608), Expect = 1e-61,   Method: Composition-based stats.
 Identities = 57/237 (24%), Positives = 105/237 (44%), Gaps = 24/237 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG-QHVFTAHRLDRPTSGV 60
           LEI+++D+ L+ +NKPSG LVH +         +   ++  +     +  HRLD+ TSG+
Sbjct: 79  LEIVFEDQDLLVINKPSGMLVHPTSFQEQNT--LANALKHYLKTDDFYITHRLDKNTSGL 136

Query: 61  LLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEA---VLDYPLVEELDKIADKFAR 117
           +++  + +A   L QQF Q  ++K Y+AIV           +++ P+             
Sbjct: 137 IVICKNQKALCCLQQQFMQKTVKKSYYAIVHNRFDMHHLHFMINEPIGHSYQDKLRMKTG 196

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
           + K  + A++  + +                  LVE+   TGR HQ+R H+ H+ HPI  
Sbjct: 197 DAKNVKEAISIVKVIEQY-----------QNTALVEVSIITGRTHQIRVHMRHINHPIYN 245

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           D  +G  +               LH+  +S  HP T E +     + + ++  + ++
Sbjct: 246 DPLYGISKHTTPYE-------QYLHSFYISFIHPSTNEIVEFKTLMPNEFINLIKEW 295


Searching..................................................done


Results from round 3


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value
Sequences used in model and found again:

UniRef50_Q3ABZ7 Pseudouridine synthase n=2 Tax=Bacteria RepID=Q3...   335   7e-91
UniRef50_C6XFD0 Pseudouridine synthase n=1 Tax=Candidatus Liberi...   332   6e-90
UniRef50_B9Y836 Pseudouridine synthase n=3 Tax=Firmicutes RepID=...   331   2e-89
UniRef50_B0TGQ0 Pseudouridine synthase n=44 Tax=Bacteria RepID=B...   330   3e-89
UniRef50_Q9JVB6 Ribosomal large subunit pseudouridine synthase D...   328   1e-88
UniRef50_Q82WZ5 Ribosomal large subunit pseudouridine synthase D...   328   1e-88
UniRef50_Q312A0 Pseudouridine synthase, RluD n=6 Tax=Bacteria Re...   326   4e-88
UniRef50_Q45826 Uncharacterized RNA pseudouridine synthase Caur_...   326   6e-88
UniRef50_P50513 Ribosomal large subunit pseudouridine synthase D...   323   3e-87
UniRef50_C9KPZ8 Pseudouridine synthase n=1 Tax=Mitsuokella multa...   323   4e-87
UniRef50_C7NAV5 Pseudouridine synthase n=5 Tax=Fusobacteriaceae ...   323   4e-87
UniRef50_Q47417 tRNA pseudouridine synthase C n=252 Tax=cellular...   323   5e-87
UniRef50_A9IQ66 Pseudouridine synthase n=5 Tax=Bacteria RepID=A9...   322   8e-87
UniRef50_B2UL66 Pseudouridine synthase n=2 Tax=Verrucomicrobiace...   322   9e-87
UniRef50_C4FYR8 Pseudouridine synthase n=1 Tax=Abiotrophia defec...   322   9e-87
UniRef50_A7NB61 Pseudouridine synthase n=18 Tax=Francisella RepI...   319   4e-86
UniRef50_Q6AJM1 Pseudouridine synthase n=1 Tax=Desulfotalea psyc...   319   4e-86
UniRef50_A9BFW4 Pseudouridine synthase n=8 Tax=Thermotogaceae Re...   319   7e-86
UniRef50_B8FT16 Pseudouridine synthase n=70 Tax=Bacteria RepID=B...   318   1e-85
UniRef50_D2L0S2 Pseudouridine synthase, RluA family n=1 Tax=Desu...   318   1e-85
UniRef50_Q8XYX8 Ribosomal large subunit pseudouridine synthase D...   317   2e-85
UniRef50_D0MJ49 Pseudouridine synthase n=2 Tax=Bacteria RepID=D0...   317   2e-85
UniRef50_B2A2J2 Pseudouridine synthase n=1 Tax=Natranaerobius th...   317   3e-85
UniRef50_A3EQJ0 Pseudouridine synthase n=1 Tax=Leptospirillum ru...   316   3e-85
UniRef50_A1URK8 Pseudouridine synthase n=2 Tax=Bartonella RepID=...   316   6e-85
UniRef50_A7HM17 Pseudouridine synthase n=2 Tax=Thermotogaceae Re...   316   7e-85
UniRef50_B8FLB4 Pseudouridine synthase n=2 Tax=Bacteria RepID=B8...   315   7e-85
UniRef50_A3M2Y1 Pseudouridine synthase n=18 Tax=Gammaproteobacte...   315   9e-85
UniRef50_C6BSG2 Pseudouridine synthase, RluA family n=1 Tax=Desu...   313   3e-84
UniRef50_B8CWM0 Pseudouridine synthase n=1 Tax=Halothermothrix o...   312   6e-84
UniRef50_Q1MQ60 Pseudouridylate synthases, 23S RNA-specific n=1 ...   312   8e-84
UniRef50_B9JRD0 Pseudouridine synthase n=1 Tax=Agrobacterium vit...   312   9e-84
UniRef50_B9L028 Pseudouridine synthase n=2 Tax=Thermomicrobia (c...   311   1e-83
UniRef50_A6SXT6 Pseudouridine synthase n=1 Tax=Janthinobacterium...   311   2e-83
UniRef50_A7HV45 Pseudouridine synthase n=56 Tax=Alphaproteobacte...   310   2e-83
UniRef50_C0BNA6 Pseudouridine synthase n=7 Tax=Bacteroidetes Rep...   310   3e-83
UniRef50_C6WV38 Pseudouridine synthase n=3 Tax=Proteobacteria Re...   310   3e-83
UniRef50_B6AN83 Pseudouridine synthase n=2 Tax=Leptospirillum Re...   309   6e-83
UniRef50_C7RM94 Pseudouridine synthase n=11 Tax=Proteobacteria R...   309   7e-83
UniRef50_C8QZ10 Pseudouridine synthase n=1 Tax=Desulfurivibrio a...   309   7e-83
UniRef50_C8NEP8 Pseudouridine synthase n=1 Tax=Granulicatella ad...   309   8e-83
UniRef50_B8E0R4 Pseudouridine synthase n=1 Tax=Dictyoglomus turg...   308   1e-82
UniRef50_D1RB31 Pseudouridine synthase n=1 Tax=Parachlamydia aca...   308   1e-82
UniRef50_Q49WX8 Pseudouridine synthase n=1 Tax=Staphylococcus sa...   307   2e-82
UniRef50_Q2W2D5 Pseudouridine synthase n=39 Tax=Bacteria RepID=Q...   307   2e-82
UniRef50_C4FWV7 Pseudouridine synthase n=2 Tax=Firmicutes RepID=...   307   2e-82
UniRef50_P74346 Uncharacterized RNA pseudouridine synthase slr16...   307   2e-82
UniRef50_C4XSN0 Ribosomal large subunit pseudouridine synthase D...   307   2e-82
UniRef50_A5WFS2 Pseudouridine synthase n=3 Tax=Psychrobacter Rep...   307   3e-82
UniRef50_C8X1I9 Pseudouridine synthase, RluA family n=1 Tax=Desu...   307   3e-82
UniRef50_C8PVB8 Pseudouridine synthase n=2 Tax=Moraxellaceae Rep...   307   3e-82
UniRef50_Q3A0C2 Pseudouridine synthase n=13 Tax=Bacteria RepID=Q...   306   7e-82
UniRef50_D1PCC3 Pseudouridine synthase n=1 Tax=Prevotella copri ...   305   7e-82
UniRef50_A9BMW0 Pseudouridine synthase n=10 Tax=Comamonadaceae R...   305   8e-82
UniRef50_A5EX53 Pseudouridine synthase n=1 Tax=Dichelobacter nod...   305   1e-81
UniRef50_B5YKV0 Pseudouridine synthase n=1 Tax=Thermodesulfovibr...   305   1e-81
UniRef50_Q3AVX8 Pseudouridine synthase n=40 Tax=cellular organis...   304   1e-81
UniRef50_D2BIX0 Pseudouridine synthase n=5 Tax=Dehalococcoides R...   304   1e-81
UniRef50_A0L9J0 Pseudouridine synthase n=1 Tax=Magnetococcus sp....   304   1e-81
UniRef50_Q2LWV4 Pseudouridine synthase n=1 Tax=Syntrophus acidit...   304   2e-81
UniRef50_Q87AR7 Ribosomal large subunit pseudouridine synthase D...   304   2e-81
UniRef50_A1AW00 Pseudouridine synthase n=2 Tax=sulfur-oxidizing ...   304   3e-81
UniRef50_D0RPR1 Pseudouridine synthase n=1 Tax=alpha proteobacte...   303   3e-81
UniRef50_B8J173 Pseudouridine synthase, RluA family n=2 Tax=Desu...   303   3e-81
UniRef50_D0KVM5 Pseudouridine synthase n=11 Tax=Proteobacteria R...   303   3e-81
UniRef50_O50310 Uncharacterized RNA pseudouridine synthase Cpar_...   303   5e-81
UniRef50_B1I3F8 Pseudouridine synthase n=2 Tax=Bacteria RepID=B1...   302   7e-81
UniRef50_A6DUC9 Pseudouridine synthase n=1 Tax=Lentisphaera aran...   302   9e-81
UniRef50_D1ANU4 Pseudouridine synthase n=14 Tax=Fusobacteriaceae...   301   1e-80
UniRef50_Q0BWH2 Pseudouridine synthase n=3 Tax=Alphaproteobacter...   301   2e-80
UniRef50_D1VS73 Pseudouridine synthase n=1 Tax=Peptoniphilus lac...   301   2e-80
UniRef50_A6C0W7 Pseudouridine synthase n=1 Tax=Planctomyces mari...   300   3e-80
UniRef50_C9LM35 Pseudouridine synthase n=1 Tax=Dialister invisus...   300   3e-80
UniRef50_D1U4S9 Pseudouridine synthase, RluA family n=1 Tax=Desu...   300   3e-80
UniRef50_A5GW76 Pseudouridine synthase n=1 Tax=Synechococcus sp....   300   3e-80
UniRef50_P65834 Ribosomal large subunit pseudouridine synthase D...   300   3e-80
UniRef50_Q13E92 Pseudouridine synthase n=28 Tax=Alphaproteobacte...   300   4e-80
UniRef50_A8GQ59 Pseudouridine synthase n=15 Tax=Rickettsia RepID...   299   5e-80
UniRef50_B8GZR6 Pseudouridine synthase n=2 Tax=Caulobacter vibri...   298   1e-79
UniRef50_D1BAB3 Pseudouridine synthase n=1 Tax=Thermanaerovibrio...   298   1e-79
UniRef50_D0J9U5 Pseudouridine synthase n=2 Tax=Blattabacterium R...   298   2e-79
UniRef50_C1F7V3 Pseudouridine synthase n=1 Tax=Acidobacterium ca...   297   2e-79
UniRef50_Q2SS88 Pseudouridine synthase n=4 Tax=Mollicutes RepID=...   297   2e-79
UniRef50_Q1ILA4 Pseudouridine synthase n=1 Tax=Candidatus Koriba...   297   3e-79
UniRef50_C8WW59 Pseudouridine synthase n=2 Tax=Alicyclobacillus ...   296   4e-79
UniRef50_C6XNC0 Pseudouridine synthase n=1 Tax=Hirschia baltica ...   296   5e-79
UniRef50_C5VRN0 Pseudouridine synthase n=1 Tax=Clostridium botul...   295   1e-78
UniRef50_B9YI75 Pseudouridine synthase, RluA family n=1 Tax='Nos...   295   1e-78
UniRef50_B6BTN1 Pseudouridine synthase n=2 Tax=Betaproteobacteri...   295   1e-78
UniRef50_Q03WF6 Pseudouridine synthase n=9 Tax=Firmicutes RepID=...   294   1e-78
UniRef50_Q6MEC0 Pseudouridine synthase n=1 Tax=Candidatus Protoc...   294   2e-78
UniRef50_B0VJ94 Pseudouridine synthase n=1 Tax=Candidatus Cloaca...   294   2e-78
UniRef50_Q8DBG5 tRNA pseudouridine synthase C n=54 Tax=Gammaprot...   294   3e-78
UniRef50_B2RIT5 Pseudouridine synthase n=80 Tax=root RepID=B2RIT...   294   3e-78
UniRef50_C7H7W3 Ribosomal large subunit pseudouridine synthase D...   293   3e-78
UniRef50_A4WSV2 Pseudouridine synthase n=41 Tax=Alphaproteobacte...   293   4e-78
UniRef50_C0ZH07 Pseudouridine synthase n=1 Tax=Brevibacillus bre...   292   5e-78
UniRef50_A3RGY8 Pseudouridine synthase n=1 Tax=uncultured bacter...   292   5e-78
UniRef50_Q4FN11 Pseudouridine synthase n=4 Tax=Bacteria RepID=Q4...   292   8e-78
UniRef50_Q8K9E9 Ribosomal large subunit pseudouridine synthase D...   292   8e-78
UniRef50_C0GNZ6 Pseudouridine synthase, RluA family n=1 Tax=Desu...   292   8e-78
UniRef50_C8S0A2 Pseudouridine synthase n=1 Tax=Rhodobacter sp. S...   292   9e-78
UniRef50_UPI00016C3FBA ribosomal large subunit pseudouridine syn...   292   1e-77
UniRef50_Q2S3B7 Pseudouridine synthase n=1 Tax=Salinibacter rube...   292   1e-77
UniRef50_A5IBH6 Pseudouridine synthase n=6 Tax=Legionella RepID=...   292   1e-77
UniRef50_B8CQ92 Pseudouridine synthase n=1 Tax=Shewanella piezot...   291   1e-77
UniRef50_A9NGF1 Pseudouridine synthase n=1 Tax=Acholeplasma laid...   291   2e-77
UniRef50_C0QAZ3 RluD1 n=1 Tax=Desulfobacterium autotrophicum HRM...   291   2e-77
UniRef50_P54604 Uncharacterized RNA pseudouridine synthase yhcT ...   291   2e-77
UniRef50_C1FEQ4 Predicted protein n=2 Tax=Micromonas RepID=C1FEQ...   290   3e-77
UniRef50_D1Y3Y9 Pseudouridine synthase n=1 Tax=Pyramidobacter pi...   289   5e-77
UniRef50_C1ZGS9 Pseudouridine synthase n=1 Tax=Planctomyces limn...   289   6e-77
UniRef50_C1A885 Pseudouridine synthase n=1 Tax=Gemmatimonas aura...   289   7e-77
UniRef50_B7GAM3 Predicted protein (Fragment) n=1 Tax=Phaeodactyl...   289   7e-77
UniRef50_B6J6C4 Pseudouridine synthase n=7 Tax=Coxiella burnetii...   289   9e-77
UniRef50_O67638 Uncharacterized RNA pseudouridine synthase aq_17...   289   9e-77
UniRef50_C7LWM1 Pseudouridine synthase, RluA family n=1 Tax=Desu...   287   2e-76
UniRef50_C1SM47 Pseudouridine synthase n=1 Tax=Denitrovibrio ace...   287   2e-76
UniRef50_Q7UHX8 Pseudouridine synthase n=1 Tax=Rhodopirellula ba...   287   2e-76
UniRef50_A0Q1S9 Pseudouridine synthase n=32 Tax=Clostridium RepI...   287   2e-76
UniRef50_C6J6E3 Pseudouridine synthase n=2 Tax=Bacillales RepID=...   287   2e-76
UniRef50_D2R7T3 Pseudouridine synthase, RluA family n=1 Tax=Pire...   287   2e-76
UniRef50_Q2GGY1 Pseudouridine synthase n=13 Tax=Rickettsiales Re...   287   3e-76
UniRef50_A0LPH5 Pseudouridine synthase n=1 Tax=Syntrophobacter f...   287   3e-76
UniRef50_A3HSB5 Pseudouridine synthase n=1 Tax=Algoriphagus sp. ...   287   3e-76
UniRef50_C6JBH1 Pseudouridine synthase n=1 Tax=Ruminococcus sp. ...   286   4e-76
UniRef50_Q5PAD0 Pseudouridine synthase n=5 Tax=Anaplasma RepID=Q...   286   4e-76
UniRef50_D1N7N8 Pseudouridine synthase, RluA family n=1 Tax=Vict...   286   4e-76
UniRef50_Q1J0S8 Pseudouridine synthase n=7 Tax=Deinococci RepID=...   286   5e-76
UniRef50_A8ZXZ8 Pseudouridine synthase n=1 Tax=Desulfococcus ole...   286   5e-76
UniRef50_A4RT55 Predicted protein (Fragment) n=3 Tax=Chlorophyta...   286   6e-76
UniRef50_C0QV86 Pseudouridine synthase n=2 Tax=Brachyspira RepID...   286   6e-76
UniRef50_C4XFS9 Pseudouridine synthase n=2 Tax=Mycoplasma RepID=...   285   9e-76
UniRef50_Q30SZ1 Pseudouridine synthase n=2 Tax=Proteobacteria Re...   285   1e-75
UniRef50_B0K860 Pseudouridine synthase n=11 Tax=Thermoanaerobact...   285   1e-75
UniRef50_C2D7A7 Pseudouridine synthase n=1 Tax=Atopobium vaginae...   284   2e-75
UniRef50_Q15QZ8 Pseudouridine synthase n=5 Tax=Bacteria RepID=Q1...   284   3e-75
UniRef50_C6CWL6 Pseudouridine synthase n=2 Tax=Paenibacillus Rep...   284   3e-75
UniRef50_UPI0001C42CC7 hypothetical protein BpOF4_01845 n=1 Tax=...   283   4e-75
UniRef50_Q2NIN6 Pseudouridine synthase n=4 Tax=Candidatus Phytop...   283   4e-75
UniRef50_A5IZB6 Pseudouridine synthase n=4 Tax=Mycoplasma RepID=...   283   4e-75
UniRef50_C5TPY8 Pseudouridine synthase n=6 Tax=Proteobacteria Re...   282   5e-75
UniRef50_C4KBT4 Transaldolase n=2 Tax=Proteobacteria RepID=C4KBT...   282   5e-75
UniRef50_C8P3R0 Pseudouridine synthase n=1 Tax=Erysipelothrix rh...   282   6e-75
UniRef50_B7GLK3 Pseudouridine synthase n=11 Tax=Bacillaceae RepI...   282   6e-75
UniRef50_C0Q9S8 TruC n=1 Tax=Desulfobacterium autotrophicum HRM2...   282   7e-75
UniRef50_D1CBT6 Pseudouridine synthase n=1 Tax=Thermobaculum ter...   282   7e-75
UniRef50_Q01Q94 Pseudouridine synthase n=1 Tax=Candidatus Soliba...   282   8e-75
UniRef50_A1K5H7 Pseudouridine synthase n=5 Tax=Proteobacteria Re...   282   9e-75
UniRef50_C5J6Q2 Pseudouridine synthase n=1 Tax=Mycoplasma conjun...   282   1e-74
UniRef50_B1ZYX0 Pseudouridine synthase n=4 Tax=Verrucomicrobia R...   281   1e-74
UniRef50_A9IIW7 Pseudouridine synthase n=5 Tax=Bordetella RepID=...   281   1e-74
UniRef50_C9RQF0 Pseudouridine synthase, RluA family n=1 Tax=Fibr...   281   1e-74
UniRef50_Q89AD9 Ribosomal large subunit pseudouridine synthase D...   281   2e-74
UniRef50_Q39Z12 Pseudouridine synthase n=3 Tax=Proteobacteria Re...   281   2e-74
UniRef50_A3DDK9 Pseudouridine synthase, RluA family n=3 Tax=Clos...   281   2e-74
UniRef50_C0QPR5 Pseudouridine synthase n=4 Tax=Hydrogenothermace...   281   2e-74
UniRef50_Q1Q689 Similar to ribosomal large subunit pseudouridine...   281   2e-74
UniRef50_A6NQQ9 Pseudouridine synthase n=1 Tax=Bacteroides capil...   280   3e-74
UniRef50_A8MF48 Pseudouridine synthase n=12 Tax=Clostridiaceae R...   280   4e-74
UniRef50_O31613 Uncharacterized RNA pseudouridine synthase yjbO ...   280   4e-74
UniRef50_B4U613 Pseudouridine synthase, RluA family n=1 Tax=Hydr...   280   4e-74
UniRef50_C1CWT3 Pseudouridine synthase n=1 Tax=Deinococcus deser...   280   4e-74
UniRef50_B8CWB7 Pseudouridine synthase n=1 Tax=Halothermothrix o...   279   7e-74
UniRef50_Q6MGX8 Pseudouridine synthase n=1 Tax=Bdellovibrio bact...   279   7e-74
UniRef50_D1AV01 Pseudouridine synthase n=2 Tax=Bacteria RepID=D1...   279   8e-74
UniRef50_C6LL16 Pseudouridine synthase n=3 Tax=Clostridiales Rep...   278   1e-73
UniRef50_C0ZCK6 Pseudouridine synthase n=1 Tax=Brevibacillus bre...   278   1e-73
UniRef50_B3DV48 Pseudouridine synthase n=1 Tax=Methylacidiphilum...   277   2e-73
UniRef50_B7HGW1 Pseudouridine synthase n=52 Tax=Bacillales RepID...   277   2e-73
UniRef50_Q8ZQ16 Ribosomal large subunit pseudouridine synthase C...   277   2e-73
UniRef50_A1HR26 Pseudouridine synthase, RluA family n=1 Tax=Ther...   277   2e-73
UniRef50_B8FTI5 Pseudouridine synthase n=2 Tax=Desulfitobacteriu...   277   2e-73
UniRef50_C7MN62 Pseudouridine synthase n=8 Tax=Coriobacteriaceae...   277   2e-73
UniRef50_Q0F3G2 Possible pseudouridine synthase n=1 Tax=Mariprof...   277   4e-73
UniRef50_A5ZUU7 Pseudouridine synthase n=1 Tax=Ruminococcus obeu...   276   4e-73
UniRef50_C9M7B4 Pseudouridine synthase n=1 Tax=Jonquetella anthr...   276   7e-73
UniRef50_C0MA80 Pseudouridine synthase n=6 Tax=Streptococcus Rep...   275   1e-72
UniRef50_Q14NK8 Probable pseudouridine synthase d protein n=1 Ta...   275   1e-72
UniRef50_A8RHQ2 Pseudouridine synthase n=2 Tax=Clostridium RepID...   275   1e-72
UniRef50_Q5QZ45 Pseudouridine synthase n=2 Tax=Gammaproteobacter...   275   1e-72
UniRef50_P59838 Ribosomal large subunit pseudouridine synthase D...   273   4e-72
UniRef50_Q31IZ8 Pseudouridine synthase n=2 Tax=Proteobacteria Re...   273   5e-72
UniRef50_Q9KQH0 Ribosomal large subunit pseudouridine synthase C...   272   9e-72
UniRef50_D2RBY1 Pseudouridine synthase, RluA family n=1 Tax=Gard...   271   1e-71
UniRef50_A6GP31 Pseudouridine synthase n=1 Tax=Limnobacter sp. M...   271   2e-71
UniRef50_B7GEZ0 Pseudouridine synthase n=7 Tax=Bacillaceae RepID...   271   2e-71
UniRef50_Q126H9 Pseudouridine synthase n=1 Tax=Polaromonas sp. J...   271   2e-71
UniRef50_A6TSZ4 Pseudouridine synthase n=1 Tax=Alkaliphilus meta...   270   3e-71
UniRef50_A6VXE8 Pseudouridine synthase n=2 Tax=Marinomonas RepID...   270   4e-71
UniRef50_A0L8J2 Pseudouridine synthase n=1 Tax=Magnetococcus sp....   270   4e-71
UniRef50_C0E4Q3 Pseudouridine synthase n=2 Tax=Corynebacterium m...   269   5e-71
UniRef50_C2W5F3 Pseudouridine synthase n=4 Tax=Bacillus RepID=C2...   269   6e-71
UniRef50_C0Z877 Pseudouridine synthase n=1 Tax=Brevibacillus bre...   269   6e-71
UniRef50_Q89AH2 Ribosomal large subunit pseudouridine synthase C...   269   7e-71
UniRef50_P44433 Ribosomal large subunit pseudouridine synthase C...   269   8e-71
UniRef50_A5VJ18 Pseudouridine synthase, RluA family n=13 Tax=Lac...   269   8e-71
UniRef50_A1U2H1 Pseudouridine synthase n=1 Tax=Marinobacter aqua...   269   9e-71
UniRef50_C8PZW5 Pseudouridine synthase n=1 Tax=Enhydrobacter aer...   269   9e-71
UniRef50_A6LDZ7 Pseudouridine synthase n=26 Tax=Bacteroidales Re...   268   1e-70
UniRef50_D2ELJ1 Pseudouridine synthase n=1 Tax=Pediococcus acidi...   267   2e-70
UniRef50_UPI0001AEC02F pseudouridylate synthase, 23S RNA-specifi...   267   2e-70
UniRef50_A7H6D3 Pseudouridine synthase n=6 Tax=Cystobacterineae ...   267   3e-70
UniRef50_D2M2K8 Pseudouridine synthase, RluA family n=1 Tax=Baci...   267   3e-70
UniRef50_A4J479 Pseudouridine synthase n=1 Tax=Desulfotomaculum ...   267   3e-70
UniRef50_Q8ERS8 Pseudouridine synthase n=2 Tax=Bacillaceae RepID...   267   3e-70
UniRef50_B1XXM0 Pseudouridine synthase n=6 Tax=Burkholderiales R...   267   3e-70
UniRef50_D2QPA6 Pseudouridine synthase n=1 Tax=Spirosoma lingual...   266   4e-70
UniRef50_Q3JQ55 Pseudouridine synthase n=170 Tax=cellular organi...   266   5e-70
UniRef50_C7GZW0 Pseudouridine synthase n=1 Tax=Eubacterium saphe...   266   5e-70
UniRef50_A3ZV48 Pseudouridine synthase n=1 Tax=Blastopirellula m...   266   6e-70
UniRef50_Q8ZFU1 Ribosomal large subunit pseudouridine synthase C...   266   6e-70
UniRef50_C0EHV8 Putative uncharacterized protein n=1 Tax=Clostri...   266   7e-70
UniRef50_C8NZX3 Pseudouridine synthase n=1 Tax=Erysipelothrix rh...   266   8e-70
UniRef50_C5RBB6 23S rRNA pseudouridylate synthase RluD n=1 Tax=W...   266   8e-70
UniRef50_Q03EW7 Pseudouridine synthase n=1 Tax=Pediococcus pento...   265   1e-69
UniRef50_C6VVP1 Pseudouridine synthase n=4 Tax=Bacteroidetes Rep...   265   1e-69
UniRef50_B0S119 Pseudouridine synthase n=2 Tax=Finegoldia magna ...   265   1e-69
UniRef50_D0L1K7 Pseudouridine synthase n=1 Tax=Halothiobacillus ...   265   1e-69
UniRef50_B1H0R5 Pseudouridine synthase n=1 Tax=uncultured Termit...   264   1e-69
UniRef50_Q63E77 Pseudouridine synthase n=73 Tax=Bacillaceae RepI...   264   1e-69
UniRef50_A9BZ16 Pseudouridine synthase n=9 Tax=Burkholderiales R...   264   1e-69
UniRef50_A8Z5T0 Pseudouridine synthase n=3 Tax=Candidatus Sulcia...   264   1e-69
UniRef50_A7I2U9 Pseudouridine synthase n=23 Tax=Campylobacterale...   264   1e-69
UniRef50_C4ZAQ6 Pseudouridine synthase n=15 Tax=Clostridiales Re...   264   2e-69
UniRef50_A4FXG9 Pseudouridine synthase, RluA family n=5 Tax=Meth...   264   2e-69
UniRef50_B9DS29 Pseudouridine synthase n=85 Tax=Firmicutes RepID...   264   2e-69
UniRef50_Q83G23 Pseudouridine synthase n=2 Tax=Tropheryma whippl...   264   2e-69
UniRef50_B8I750 Pseudouridine synthase, RluA family n=2 Tax=Clos...   264   2e-69
UniRef50_Q1WS43 Pseudouridine synthase n=3 Tax=Lactobacillus Rep...   264   2e-69
UniRef50_B5ZBC1 RluA n=15 Tax=Ureaplasma RepID=B5ZBC1_UREU1           264   2e-69
UniRef50_Q057H9 Pseudouridine synthase n=1 Tax=Buchnera aphidico...   264   3e-69
UniRef50_Q38W13 Pseudouridine synthase n=4 Tax=Lactobacillus Rep...   263   4e-69
UniRef50_Q2IJ40 Pseudouridine synthase n=7 Tax=Cystobacterineae ...   263   4e-69
UniRef50_A4BJ00 Pseudouridine synthase n=1 Tax=Reinekea blandens...   263   5e-69
UniRef50_D0BL50 Pseudouridine synthase n=1 Tax=Granulicatella el...   262   6e-69
UniRef50_C1ZB48 Pseudouridine synthase, RluA family n=1 Tax=Plan...   262   6e-69
UniRef50_B4RVP9 Pseudouridine synthase n=1 Tax=Alteromonas macle...   262   8e-69
UniRef50_A9GBV3 Pseudouridine synthase n=1 Tax=Sorangium cellulo...   262   9e-69
UniRef50_Q1N5G6 Pseudouridine synthase n=1 Tax=Bermanella marisr...   262   9e-69
UniRef50_UPI0001C37137 ribosomal large subunit pseudouridine syn...   262   1e-68
UniRef50_B1YJB1 Pseudouridine synthase n=1 Tax=Exiguobacterium s...   262   1e-68
UniRef50_B2KBB0 Pseudouridine synthase n=1 Tax=Elusimicrobium mi...   261   1e-68
UniRef50_B5JL25 Pseudouridine synthase n=1 Tax=Verrucomicrobiae ...   261   1e-68
UniRef50_B7BE87 Pseudouridine synthase n=8 Tax=Bacteroidales Rep...   261   1e-68
UniRef50_Q0F3G4 Pseudouridine synthase n=1 Tax=Mariprofundus fer...   261   2e-68
UniRef50_C9M5C8 Pseudouridine synthase n=1 Tax=Jonquetella anthr...   261   2e-68

Sequences not found previously or not previously below threshold:

UniRef50_Q5Z8P2 RNA pseudourine synthase 2, chloroplastic n=6 Ta...   272   7e-72
UniRef50_Q3ECD0 RNA pseudourine synthase 2, chloroplastic n=4 Ta...   272   1e-71
UniRef50_B6TXP4 RNA binding protein n=3 Tax=Poaceae RepID=B6TXP4...   271   2e-71

>UniRef50_Q3ABZ7 Pseudouridine synthase n=2 Tax=Bacteria RepID=Q3ABZ7_CARHZ
          Length = 305

 Score =  335 bits (861), Expect = 7e-91,   Method: Composition-based stats.
 Identities = 72/241 (29%), Positives = 117/241 (48%), Gaps = 25/241 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ------HVFTAHRLDR 55
           L+I+Y+DE LV VNK +G +VH +  + D  +V       Q              HRLD+
Sbjct: 82  LDIVYEDEDLVVVNKKAGMVVHPAEGNWDGTLVNALLYHCQNLSGIGGVLRPGIVHRLDK 141

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADK 114
            TSG+L++  +  A + LA+Q ++ +  + Y  IV G+L  +E ++D P+          
Sbjct: 142 DTSGLLVVAKNDLAHQSLAEQIKEKKAVREYWTIVHGYLKNKEGIIDLPIGRHPRDRQKM 201

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
                   + A T Y+ L                + L++ +  TGR HQ+R H ++L HP
Sbjct: 202 AVV--SNGKTAQTVYKVLEEF----------NKGFTLIQAKLLTGRTHQIRVHFSYLGHP 249

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           ++GD K+G           FG++R MLHA +LS  HP +GE L   A L + + + L++ 
Sbjct: 250 VLGDPKYGHQ------NNPFGVKRQMLHAIKLSFIHPRSGELLEFTAPLPEDFQRVLAKL 303

Query: 235 G 235
            
Sbjct: 304 R 304


>UniRef50_C6XFD0 Pseudouridine synthase n=1 Tax=Candidatus Liberibacter asiaticus
           str. psy62 RepID=C6XFD0_LIBAP
          Length = 340

 Score =  332 bits (853), Expect = 6e-90,   Method: Composition-based stats.
 Identities = 61/257 (23%), Positives = 117/257 (45%), Gaps = 27/257 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG-------QHVFTAHRLD 54
           L+ILY+D+ ++ +NKP+G +VH +  +    +V                 +     HRLD
Sbjct: 90  LDILYEDDDIIVINKPAGLVVHPAPGNWTGTLVNALLYHCHNNLSSINGVKRPGIVHRLD 149

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQH----QIQKRYHAIVRGWL-MEEAVLDYPLVEELD 109
           + T+GV+++  +  A + L++QF  H    ++++ Y+A+V G    +  +++ PL     
Sbjct: 150 KDTTGVMVVAKNDLAHQKLSEQFVDHGKSTRLKRAYYAMVWGIPLPDSGIINAPLGRCKS 209

Query: 110 KIADKFAR--EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRH 167
               +  +  +DK    A+THY+ +                  L++   +TGR HQ+R H
Sbjct: 210 NRLRRAVKGIDDKTADSAITHYQTIEIYNKNSNFA------VSLLKCHLETGRTHQIRVH 263

Query: 168 LAHLRHPIIGDSKHGDL-------RQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIH 220
           +AH  +P+IGD  +G           N + +    L R  LHA  LS +HP   + +   
Sbjct: 264 MAHKGNPLIGDPLYGKGFKTKANIVNNNAKSAILSLARQALHAHSLSFSHPRNNQDMDFQ 323

Query: 221 AGLDDTWMQALSQFGWR 237
             + +  +  + +   +
Sbjct: 324 VPIPEDMLTVIRKLNEK 340


>UniRef50_B9Y836 Pseudouridine synthase n=3 Tax=Firmicutes RepID=B9Y836_9FIRM
          Length = 307

 Score =  331 bits (850), Expect = 2e-89,   Method: Composition-based stats.
 Identities = 68/243 (27%), Positives = 112/243 (46%), Gaps = 26/243 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ------HVFTAHRLDR 55
           L ++Y+D  ++ +NKP G +VH    + D  +V                      HR+D+
Sbjct: 80  LNVVYEDHDVIVINKPKGLVVHPGPGNPDHTLVNGLLWHCHDLSGINGVLRPGIVHRIDK 139

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADK 114
            TSG+++   +  A + LA+Q  +    ++Y+A+V G +  E   +D P+  +       
Sbjct: 140 DTSGLIVACKNDNAHQSLAKQLAEKTAGRQYYALVHGVINHEYGTIDAPIGRDEKDRQKM 199

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
               +K  +PA+TH++ +   +            Y LV    +TGR HQ+R H+ ++  P
Sbjct: 200 AVT-EKNSRPAITHFKVVERFD-----------NYTLVSCRLETGRTHQIRVHMQYIGFP 247

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           I+GD K+       S  +    Q  MLHA QLS THP TGE +T  A L   +   L+Q 
Sbjct: 248 IVGDPKY-------SLRKTLPTQGQMLHAYQLSFTHPSTGERMTFEAPLPPEFEALLTQL 300

Query: 235 GWR 237
              
Sbjct: 301 RQE 303


>UniRef50_B0TGQ0 Pseudouridine synthase n=44 Tax=Bacteria RepID=B0TGQ0_HELMI
          Length = 369

 Score =  330 bits (847), Expect = 3e-89,   Method: Composition-based stats.
 Identities = 72/253 (28%), Positives = 119/253 (47%), Gaps = 27/253 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ------HVFTAHRLDR 55
           LEI++QD  +  +NKP+G +VH +       +V       +              HR+D+
Sbjct: 112 LEIIFQDADIAVINKPAGLVVHPAEGHWSGTLVNALLYHIKDLSGINGELRPGIVHRIDK 171

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADK 114
            TSG+L++  +  A   L +Q + H++++ Y A+V G +  E   ++ P+  +       
Sbjct: 172 DTSGLLVVAKNDRAHIHLTEQVKDHRVRREYLAVVHGVIGAETGRVEAPIGRDPKDRQRM 231

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
                 G + A+TH+R LA           P   + L+    +TGR HQ+R HLAH+ HP
Sbjct: 232 AVI--AGGKSAITHFRVLARY---------PEQGFSLLHCRLETGRTHQIRVHLAHIGHP 280

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           + GD K+G  +        FGL    LHA +L   HP +GEP+   A   + ++Q L   
Sbjct: 281 VAGDPKYGPRK------AAFGLTGQALHAWKLEFVHPRSGEPMRFQADPPEPFVQVLQAL 334

Query: 235 GWRGLLPENERVE 247
               + P N+R +
Sbjct: 335 Q---MTPTNQRDQ 344


>UniRef50_Q9JVB6 Ribosomal large subunit pseudouridine synthase D n=39
           Tax=Proteobacteria RepID=RLUD_NEIMA
          Length = 374

 Score =  328 bits (843), Expect = 1e-88,   Method: Composition-based stats.
 Identities = 62/255 (24%), Positives = 111/255 (43%), Gaps = 19/255 (7%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG---QHVFTAHRLDRPTS 58
           L+I+Y+D+ ++ VNKP+G +VH +  +    ++                   HRLD+ TS
Sbjct: 105 LDIVYEDDTVIVVNKPAGLVVHPAAGNWTGTLLNGLLAHCPELSQIPRAGIVHRLDKETS 164

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           G++++  +  A   L  Q ++  +++ Y A+  G +  +  ++  +  +          +
Sbjct: 165 GLMVVAKTLPAQNSLVWQLQERTVKRIYRAVANGIVPFDGKIETQIGRDPHNRLKMAVVK 224

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
             G +PAVTH + L                +  +E   +TGR HQ+R H+    HP+ GD
Sbjct: 225 -FGGKPAVTHVKVLERYLA-----------HSYIECSLETGRTHQIRVHMREANHPLAGD 272

Query: 179 SKHGDLRQNRSGAEHFGLQ----RLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
             +G+ R          ++    R  LHA +LS THP +GE ++  A + D     LS  
Sbjct: 273 PVYGNPRHPCGDTVKEAVKSLGARQALHAYRLSFTHPESGETVSFEAPIPDDIYHLLSVL 332

Query: 235 GWRGLLPENERVEFS 249
                L  +   E  
Sbjct: 333 RLEAGLDSSLSNEEE 347


>UniRef50_Q82WZ5 Ribosomal large subunit pseudouridine synthase D n=2
           Tax=Nitrosomonas RepID=RLUD_NITEU
          Length = 344

 Score =  328 bits (842), Expect = 1e-88,   Method: Composition-based stats.
 Identities = 70/238 (29%), Positives = 111/238 (46%), Gaps = 17/238 (7%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG---QHVFTAHRLDRPTS 58
           L+IL++D+ L+ ++KP+G +VH    +    ++                   HRLD+ T+
Sbjct: 109 LKILFEDDHLIIIDKPAGLVVHPGNGNWHGTLLNALLNHAPQLSQVPRAGIVHRLDKDTT 168

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           G+L++  + EA   LA+Q +Q  +++ Y A+V G L ++ V+D P+              
Sbjct: 169 GLLVVAKTIEAQFDLARQLQQRTVKRHYLALVLGKLEKDGVVDAPIGRHPIHRTRMAVV- 227

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
            +  +PA THYR L                  L+    +TGR HQ+R HL  + HP+ GD
Sbjct: 228 -QNGKPARTHYRVLEKFTAS-----------TLLHCSLETGRTHQIRVHLLSIGHPLAGD 275

Query: 179 SKHGDLRQNRSGAEH-FGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFG 235
             +G    + S A+    L R  LHA QL LTHP +G+ L   + L D     L    
Sbjct: 276 PVYGRTSPDPSTADAVVRLPRQALHAWQLELTHPHSGQILLWESPLPDDMAALLQAIR 333


>UniRef50_Q312A0 Pseudouridine synthase, RluD n=6 Tax=Bacteria RepID=Q312A0_DESDG
          Length = 578

 Score =  326 bits (838), Expect = 4e-88,   Method: Composition-based stats.
 Identities = 71/269 (26%), Positives = 113/269 (42%), Gaps = 25/269 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRD-----QIGQHVFTAHRLDRP 56
           LE+LY+D  ++ +NKP+G  VH +    +  +V            Q G      HR+D+ 
Sbjct: 119 LEVLYRDAHMLVINKPAGLTVHPAPSCPEGTLVHRLLHHFPELEAQEGFRPGIVHRIDKD 178

Query: 57  TSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADKF 115
           TSG+LL+ L+ +A   L+  F   +I K Y A+V+G    +   +D P+           
Sbjct: 179 TSGLLLIALTEKARLALSDAFAGRRIHKEYLALVKGIPEGDSGEIDAPVGRHPTHKTRMA 238

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
               +G + A++ +R L              T + LV +   TGR HQ+R H+ H  HP+
Sbjct: 239 VV--RGGREALSTWRVL-----LADPHGGGGTGWTLVAVRIHTGRTHQIRVHMQHTGHPL 291

Query: 176 IGDSKHGDLRQNRSGAEHFGL----QRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
            GD+ +G +           L     R MLHA ++S  HP TG P+         +   +
Sbjct: 292 WGDALYGGMPGREELQTTPALAQTATRQMLHAWKISFDHPVTGAPMQFTLPPPADFGTLI 351

Query: 232 SQFGWRGLLPENERVEFSAPSGQDGEISS 260
              G         R +    +G  G   S
Sbjct: 352 RDLG--------SRCQRVVITGMPGCGKS 372


>UniRef50_Q45826 Uncharacterized RNA pseudouridine synthase Caur_0901 n=5
           Tax=Chloroflexi (class) RepID=Y901_CHLAA
          Length = 316

 Score =  326 bits (836), Expect = 6e-88,   Method: Composition-based stats.
 Identities = 76/242 (31%), Positives = 109/242 (45%), Gaps = 24/242 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRD-----QIGQHVFTAHRLDRP 56
           L+++Y+D  +  +NKP+G +VH +       +V     R               HRLDR 
Sbjct: 91  LDVVYEDADIAVINKPAGMVVHPAPGHPRGTLVNALLARYPDLAIGGELRPGIVHRLDRD 150

Query: 57  TSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFA 116
           TSG+L++    +A R L  Q +  +++K Y A+V G   E   +D P+  +         
Sbjct: 151 TSGLLVIARHDQAMRSLVDQQQARRMRKIYQALVIGRPPETGTIDAPIGRDPRDRLRMAV 210

Query: 117 REDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPII 176
             D   +PA THYR L T              Y L+E++ +TGR HQ+R HL HL +PI+
Sbjct: 211 VPD--GRPARTHYRLLDTF-----------GDYSLLEVQLETGRTHQIRVHLRHLGYPIV 257

Query: 177 GDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGW 236
           GD  +G  R       H  L R  LHA+ L L HP +G      A L       L Q   
Sbjct: 258 GDPVYGPRRS------HLHLSRQFLHAAYLGLVHPRSGRWQEFTAPLPADLQIVLRQLQD 311

Query: 237 RG 238
           R 
Sbjct: 312 RA 313


>UniRef50_P50513 Ribosomal large subunit pseudouridine synthase D n=8
           Tax=Sphingomonadales RepID=RLUD_ZYMMO
          Length = 317

 Score =  323 bits (830), Expect = 3e-87,   Method: Composition-based stats.
 Identities = 69/241 (28%), Positives = 107/241 (44%), Gaps = 19/241 (7%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG-------QHVFTAHRLD 54
           LEI+++DE L+ VNKP+G +VH +  + D  +V                       HR+D
Sbjct: 82  LEIVFEDEHLLVVNKPAGMVVHPAAGNYDNTLVNALLYHCAGKLSGIGGVARPGIVHRID 141

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADK 114
           + TSG+L++  +  A   LA QF  H I +RY AIV G    +  +D PL          
Sbjct: 142 KDTSGLLVVAKTDPAHAGLAAQFADHSINRRYRAIVDGHPSLQGHVDAPLARSSVNRQKM 201

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
               D   + AVTHYR +            P     L+E   +TGR HQ+R H++ + H 
Sbjct: 202 AIVSDGRGKRAVTHYRMI-----------TPLKNASLIECRLETGRTHQVRVHMSSIGHS 250

Query: 175 IIGDSKHGD-LRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           ++GD  +G   + + +  +    QR  LHA+ L   HP +G+ +   A +          
Sbjct: 251 LLGDPVYGRSKKAHHALLQSLAFQRQALHAAHLGFIHPISGKQVDFDAEMPQDMQLLFKM 310

Query: 234 F 234
            
Sbjct: 311 L 311


>UniRef50_C9KPZ8 Pseudouridine synthase n=1 Tax=Mitsuokella multacida DSM 20544
           RepID=C9KPZ8_9FIRM
          Length = 308

 Score =  323 bits (829), Expect = 4e-87,   Method: Composition-based stats.
 Identities = 72/243 (29%), Positives = 109/243 (44%), Gaps = 24/243 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQI------GQHVFTAHRLDR 55
           L+ILY+D  ++ +NK  G +VH +       +V       +              HRLD+
Sbjct: 80  LDILYEDSDIIVINKARGMVVHPATGIYTGTLVNALLYHCKDLSGINGEIRPGIVHRLDK 139

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADK 114
            TSGV++   +  A   LA+Q       + Y AIV G + EE  V+   +          
Sbjct: 140 DTSGVMVAAKNDAAHLDLAEQIRTKAAHRIYRAIVCGNIREEAGVIKGDIGRHPTDRKKM 199

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
               +   +PAVTH+R L                Y LVE   +TGR HQ+R H+A + HP
Sbjct: 200 AIVHEH-GKPAVTHFRVLERF-----------GAYTLVECRLETGRTHQIRVHMASIGHP 247

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           ++GD K+G  +     A  F ++   LH+ QL+LTHP T E +T  A L +   + L   
Sbjct: 248 VLGDPKYGPRK-----ACPFAIKGQALHSLQLTLTHPRTREVMTFTAPLPEDMEKILKAL 302

Query: 235 GWR 237
             +
Sbjct: 303 RAK 305


>UniRef50_C7NAV5 Pseudouridine synthase n=5 Tax=Fusobacteriaceae RepID=C7NAV5_LEPBD
          Length = 326

 Score =  323 bits (829), Expect = 4e-87,   Method: Composition-based stats.
 Identities = 67/244 (27%), Positives = 113/244 (46%), Gaps = 28/244 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQI------GQHVFTAHRLDR 55
           +EI+Y+D  L  +NK +G +VH +       +V       +              HRLD+
Sbjct: 99  IEIIYEDNDLAVINKKAGIVVHPANGHYSGTLVNAILYHIKDLSGINGEIRPGIVHRLDK 158

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADK 114
            TSG+L++  + +A   L+Q F    ++K Y AI++G L  +   +   +  + +     
Sbjct: 159 DTSGLLIIAKNDKAHLKLSQMFHDKTVKKIYLAILKGKLNQKSGRIVTQIGRDKNDRKKM 218

Query: 115 FARED-KGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
               D    + A+T+Y  ++  E           ++ LV++  +TGR HQ+R H+ HL +
Sbjct: 219 TVINDLNSGKTAITNYEVISQTE-----------KFTLVKVHIETGRTHQIRVHMKHLGY 267

Query: 174 PIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           PI+GDS +G              +R MLHA +L   HP T E L   A L + + +AL +
Sbjct: 268 PILGDSVYGRTDTE---------KRQMLHAYKLEFQHPITEENLEFIAKLPEDFKKALKK 318

Query: 234 FGWR 237
            G  
Sbjct: 319 CGLE 322


>UniRef50_Q47417 tRNA pseudouridine synthase C n=252 Tax=cellular organisms
           RepID=TRUC_PECCC
          Length = 376

 Score =  323 bits (828), Expect = 5e-87,   Method: Composition-based stats.
 Identities = 182/257 (70%), Positives = 209/257 (81%)

Query: 1   MLEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGV 60
           MLEI+YQDE LVAVNKPSGWLVHRSWLDR EKVVVMQTVRDQIGQHV+T HRLDRPTSGV
Sbjct: 115 MLEIIYQDEHLVAVNKPSGWLVHRSWLDRKEKVVVMQTVRDQIGQHVYTVHRLDRPTSGV 174

Query: 61  LLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDK 120
           LL+ LSSE  R L+QQFE HQ+QK YHA+VRG+++++ V+DY L EELDKIADKF   DK
Sbjct: 175 LLLALSSEVARALSQQFESHQMQKTYHAVVRGYVLDDGVIDYALTEELDKIADKFTNPDK 234

Query: 121 GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSK 180
            PQPAVTHYR LA  EMPVA GRYPT RY L+EL+P+TGRKHQLRRH++H+ HPIIGD+ 
Sbjct: 235 APQPAVTHYRSLAQAEMPVAIGRYPTARYSLMELKPQTGRKHQLRRHMSHIHHPIIGDTA 294

Query: 181 HGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWRGLL 240
           HGDLR NR    HF   RLMLHAS+L L HP +G+PLT+ A  D  W   ++QFGW+G+L
Sbjct: 295 HGDLRHNRGMESHFSCGRLMLHASELQLNHPVSGQPLTLQARWDAPWQGVVTQFGWKGIL 354

Query: 241 PENERVEFSAPSGQDGE 257
           PE E VEF A SGQD E
Sbjct: 355 PEFEGVEFPADSGQDSE 371


>UniRef50_A9IQ66 Pseudouridine synthase n=5 Tax=Bacteria RepID=A9IQ66_BART1
          Length = 334

 Score =  322 bits (826), Expect = 8e-87,   Method: Composition-based stats.
 Identities = 67/254 (26%), Positives = 115/254 (45%), Gaps = 25/254 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG-------QHVFTAHRLD 54
           L+ILY+D+ ++ +NKP+G +VH    +    +V                 +     HRLD
Sbjct: 81  LDILYEDDHVIVINKPAGLVVHPGNGNWTGTLVNALIYHCGNSLSGIGGVKRPGVVHRLD 140

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQH----QIQKRYHAIVRGWLMEEA-VLDYPLVEELD 109
           + TSGV+++  +  A + L+ QF  H     + +RYHA++ G        +D  L     
Sbjct: 141 KNTSGVMVVAKNDLAHKSLSAQFSDHGRTCALDRRYHALIWGTPHRNVWTIDASLGRSPH 200

Query: 110 KIADKFARE--DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRH 167
               +          + AVTH+  L        +  +      L+E   +TGR HQ+R H
Sbjct: 201 NRTKQAVVHKQTPHARHAVTHFSLLEKYGTHADSTSF----ASLLECRLETGRTHQIRVH 256

Query: 168 LAHLRHPIIGDSKHGDLRQNRSGAEHFGLQ-------RLMLHASQLSLTHPFTGEPLTIH 220
           +AH+ HP+IGD+ +G+  + +S   +  L+       R  LHA+ L+  HP +G+ ++  
Sbjct: 257 MAHIGHPLIGDTVYGNAFKTKSNTLNPTLKNAIDQFNRHALHAASLTFEHPSSGKVISFS 316

Query: 221 AGLDDTWMQALSQF 234
           A L     Q +   
Sbjct: 317 APLPQDMAQLIKHL 330


>UniRef50_B2UL66 Pseudouridine synthase n=2 Tax=Verrucomicrobiaceae
           RepID=B2UL66_AKKM8
          Length = 323

 Score =  322 bits (826), Expect = 9e-87,   Method: Composition-based stats.
 Identities = 73/258 (28%), Positives = 111/258 (43%), Gaps = 23/258 (8%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG------QHVFTAHRLDR 55
           L+ILY+DE +V +NK SG +VH +  + D  +V                +     HRLD+
Sbjct: 77  LDILYEDEDVVVINKESGMVVHPAAGNPDGTIVNALLHHCGDLSGIGGVERPGIVHRLDK 136

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADK 114
            TSG L++  +  A + L  QF     +KRY A+V+G   +    +   +          
Sbjct: 137 DTSGCLVIAKNDGAHQSLTAQFAARSTEKRYLAVVQGIPSQSSGTVFTHIGRHPVNRLKM 196

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
                   + A+T Y  L            P+T   LV     TGR HQ+R H+ +L HP
Sbjct: 197 AVVNPGSGKAAITDYDLL---------CADPSTDSSLVLCTLHTGRTHQIRVHMLYLGHP 247

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           +IGD  +    + ++        RLMLHA +L   HP TG+ +   A +   +   L  F
Sbjct: 248 LIGDPIYAKPARQKAKP-----GRLMLHAWRLGFDHPRTGKRMDFEAPVPPEYTPWLQLF 302

Query: 235 --GWRGLLPENERVEFSA 250
             G  G +PE   V+   
Sbjct: 303 PNGLYGAIPELRPVQEDG 320


>UniRef50_C4FYR8 Pseudouridine synthase n=1 Tax=Abiotrophia defectiva ATCC 49176
           RepID=C4FYR8_ABIDE
          Length = 326

 Score =  322 bits (826), Expect = 9e-87,   Method: Composition-based stats.
 Identities = 69/241 (28%), Positives = 113/241 (46%), Gaps = 22/241 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ-------HVFTAHRLD 54
           L+ILY+DE ++ +NKP G +VH +       +V       +               HR+D
Sbjct: 99  LDILYEDEDVILINKPKGMVVHPAAGHYTGTLVNALMYHCRDNLSGINGELRPGIVHRID 158

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIAD 113
             T+GV++   +  + R++A+Q ++H I+++Y AIV G    EE  ++  +         
Sbjct: 159 MDTTGVIIACKNDVSHRIIAEQLKEHSIKRKYQAIVYGVFKDEEGRIEGSIGRSKTDRKK 218

Query: 114 KFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
                D   +PAVTHYR +     P          +  +E E +TGR HQ+R H+  + H
Sbjct: 219 MAVIPD--GKPAVTHYRVIRNYTSP------NGNNFAHIECELETGRTHQIRVHMTSIGH 270

Query: 174 PIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           P++GD  +G  +        F L    LHA  L   HP TGE +  HA L + + + L++
Sbjct: 271 PLLGDEIYGAAK------NPFKLDGQALHAEMLGFVHPRTGEYMEFHAPLPEYFSKLLTK 324

Query: 234 F 234
            
Sbjct: 325 L 325


>UniRef50_A7NB61 Pseudouridine synthase n=18 Tax=Francisella RepID=A7NB61_FRATF
          Length = 332

 Score =  319 bits (820), Expect = 4e-86,   Method: Composition-based stats.
 Identities = 55/238 (23%), Positives = 106/238 (44%), Gaps = 16/238 (6%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG---QHVFTAHRLDRPTS 58
           L+I+++D+ ++ ++KP   +VH    +    V      R +           HRLD+ TS
Sbjct: 88  LKIIFEDDDIIVIDKPVNMIVHPGAGNPTGTVSNALLHRYKDQDKLPRAGIVHRLDKDTS 147

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           G+++   SS A   L QQ  + ++ ++Y AIV G + ++  ++ P+  +           
Sbjct: 148 GLMVAAKSSIAYHNLVQQLAERKVSRKYLAIVEGEIYQQGTINQPIGRDPTNRTKMAINY 207

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
               + A+T+Y  +   +            + L+E + +TGR HQ+R H+  ++HP++GD
Sbjct: 208 --RGKEAITYYTPIEVYD-----------GFTLIECQLETGRTHQIRVHMKSIKHPLVGD 254

Query: 179 SKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGW 236
             +                R  LHA +LS  HP T + +   + L +  +   +Q   
Sbjct: 255 QTYNKSSTKLEKLAITIPTRQALHAYKLSFIHPTTAKMVKFKSKLPEDMLNLKAQLEQ 312


>UniRef50_Q6AJM1 Pseudouridine synthase n=1 Tax=Desulfotalea psychrophila
           RepID=Q6AJM1_DESPS
          Length = 327

 Score =  319 bits (820), Expect = 4e-86,   Method: Composition-based stats.
 Identities = 67/243 (27%), Positives = 110/243 (45%), Gaps = 21/243 (8%)

Query: 5   LYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRD------QIGQHVFTAHRLDRPTS 58
           +Y+D+ L+ ++KP G +VH    + +  +V                      HRLD+ TS
Sbjct: 98  IYEDDSLLVLSKPPGIVVHPGNGNTEGTLVHGLLYHCREIGGVGDAIRPGIVHRLDKDTS 157

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADKFAR 117
           G +++     + R L   F++ Q+ K YHA+V G   + E  +  P+             
Sbjct: 158 GAMVVAKDERSLRTLVDSFKERQVYKVYHALVCGIPKKYEGRIVAPIGRHSVHRQKMAI- 216

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
            ++  + A T+++ +   E            Y L+ +  +TGR HQ+R H++ +  PI G
Sbjct: 217 SERTGKFAATNWQVVEVFETK-------DGPYSLLRVHIETGRTHQIRVHMSSIGCPIAG 269

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWR 237
           D  +G  RQN + A      R MLHAS+L L HP TG  ++  A L   + + L    W 
Sbjct: 270 DQVYGSKRQNPAFA------RQMLHASRLRLPHPVTGRTMSFTAPLWQDFQEVLEDMDWS 323

Query: 238 GLL 240
           G L
Sbjct: 324 GAL 326


>UniRef50_A9BFW4 Pseudouridine synthase n=8 Tax=Thermotogaceae RepID=A9BFW4_PETMO
          Length = 319

 Score =  319 bits (818), Expect = 7e-86,   Method: Composition-based stats.
 Identities = 71/241 (29%), Positives = 113/241 (46%), Gaps = 22/241 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVR-------DQIGQHVFTAHRLD 54
           L ILY+DE L+ +NKP+G +VH +   +   +V              Q    +   HRLD
Sbjct: 85  LNILYEDEELIVINKPAGLIVHPTPSIKTGTLVNALMHHVKDLDKTMQDPNRLGIVHRLD 144

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIAD 113
           + TSGVL++  ++ +  LL+++F++ +  K Y AIV G L E E  ++ PL         
Sbjct: 145 KETSGVLVVAKNAFSHHLLSKEFKERKTMKYYLAIVEGTLKEKEGEINLPLGRHPILRHK 204

Query: 114 KFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
           +        + A+T Y+ L                  LV +  +TGR HQ+R H  ++ +
Sbjct: 205 RAVVY--NGKEAITEYKTLKEF----------GDLATLVWIRLRTGRTHQIRVHFKYIGN 252

Query: 174 PIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           P+IGDS +G  +  ++      + R MLHA +L   HP T E +   A L D +   L  
Sbjct: 253 PLIGDSLYGKNKIEKNL--QIPVGRQMLHALKLGFYHPKTKEWMEFLAPLPDDFKNLLIT 310

Query: 234 F 234
            
Sbjct: 311 L 311


>UniRef50_B8FT16 Pseudouridine synthase n=70 Tax=Bacteria RepID=B8FT16_DESHD
          Length = 334

 Score =  318 bits (817), Expect = 1e-85,   Method: Composition-based stats.
 Identities = 71/245 (28%), Positives = 113/245 (46%), Gaps = 25/245 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ------HVFTAHRLDR 55
           LEILY+DE ++ VNK  G +VH +     + +V       +              HR+D+
Sbjct: 107 LEILYEDEDVLVVNKSQGMVVHPAPGAWTKTLVNALLYHCRNLSGINGVLRPGIVHRIDK 166

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADK 114
            TSG+L++  +  A + LA+Q + H + +RY AIV G +      ++ P+  +       
Sbjct: 167 DTSGLLVVAKNDLAHQGLAEQIKAHSMARRYLAIVHGVVFEPSGTVEAPIGRDPADRKKM 226

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
                +  + AVTHY  L                + L+E   +TGR HQ+R H+A+L+HP
Sbjct: 227 AVVF-QNAKEAVTHYEVLERFR-----------DFTLLEARLETGRTHQIRVHMAYLKHP 274

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           ++GD  +G  +        FGLQ  MLHA  L   HP +GE +   A     + + L + 
Sbjct: 275 VLGDPLYGPRK------NPFGLQGQMLHAQLLGFQHPRSGEYMEFSAPASGMFQKVLEEI 328

Query: 235 GWRGL 239
               L
Sbjct: 329 RRDDL 333


>UniRef50_D2L0S2 Pseudouridine synthase, RluA family n=1 Tax=Desulfovibrio sp.
           FW1012B RepID=D2L0S2_9DELT
          Length = 558

 Score =  318 bits (815), Expect = 1e-85,   Method: Composition-based stats.
 Identities = 78/269 (28%), Positives = 113/269 (42%), Gaps = 28/269 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQI-----GQHVFTAHRLDRP 56
           L +LY D+ L  ++KP G  VH +    +  +V              G+     HRLD+ 
Sbjct: 91  LRVLYADKELAVLDKPPGLTVHPAPGLPEGTLVNRLLHHFPGLREMAGERPGIVHRLDKD 150

Query: 57  TSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADKF 115
           TSG+L++ L+      LA  F   Q+ K Y A+V G    +   +  P+  +        
Sbjct: 151 TSGLLMVALTEPVRLALAADFAARQVHKTYLALVHGRPDGKGGDIRLPIGRDPKYRTKMA 210

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
               KG +PA + +R + T          P     L+E+   TGR HQ+R H+A + HPI
Sbjct: 211 V-PHKGGRPAHSRWRPVWT---------APDGTASLLEVTIFTGRTHQIRVHMAAIGHPI 260

Query: 176 IGDSKHGDLRQ----NRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
           IGD+ +G  +      R GA      R MLHA +LS THP   EP +        +    
Sbjct: 261 IGDAVYGPHQHAAWKRRGGAIARLASRQMLHAWKLSFTHPVLKEPRSFTCPPPPDF---- 316

Query: 232 SQFGWRGLLPENERVEFSAPSGQDGEISS 260
               WR LL    R +     G  G   S
Sbjct: 317 ----WRLLLLLGRRCQRIGVVGMPGCGKS 341


>UniRef50_Q8XYX8 Ribosomal large subunit pseudouridine synthase D n=94
           Tax=Proteobacteria RepID=RLUD_RALSO
          Length = 358

 Score =  317 bits (814), Expect = 2e-85,   Method: Composition-based stats.
 Identities = 63/244 (25%), Positives = 110/244 (45%), Gaps = 15/244 (6%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG---QHVFTAHRLDRPTS 58
           L+++Y+D+ L+ +NKP+G +VH +  +    V+     R             HRLD+ TS
Sbjct: 116 LDVVYEDDTLLVINKPAGLVVHPAAGNWSGTVLNGLLHRYPQAAGLPRAGIVHRLDKETS 175

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           G++++  +  A   L +Q +   +++ Y A+V G   E   +D P+  +          E
Sbjct: 176 GLMVVARTLPAQTDLVRQLQARTVKRTYLALVWGETPEAGTIDAPIGRDPRDRTRMAIIE 235

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
               +PA TH++ L  V++          +  LV+ + +TGR HQ+R H     HP++GD
Sbjct: 236 TASGKPARTHFKTLDVVDLG-------RAQVSLVQCQLETGRTHQIRVHFESEGHPLLGD 288

Query: 179 SKH-----GDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
             +         Q           R  LHA +L L HP +G+ +  HAG+ D   + +  
Sbjct: 289 PVYTRNFRRGRPQTIKAPLPAPFARQALHAVRLGLVHPASGQSVHWHAGVPDDLAELMDA 348

Query: 234 FGWR 237
               
Sbjct: 349 LEMD 352


>UniRef50_D0MJ49 Pseudouridine synthase n=2 Tax=Bacteria RepID=D0MJ49_RHOM4
          Length = 355

 Score =  317 bits (813), Expect = 2e-85,   Method: Composition-based stats.
 Identities = 69/279 (24%), Positives = 102/279 (36%), Gaps = 54/279 (19%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ---------------- 45
           L+I+Y+D +L+ VNK +G +VH +  +R   +V         G                 
Sbjct: 86  LDIVYEDPYLIVVNKQAGLVVHPARGNRSGTLVNALLYYIGSGPVRFDEEDDLPEDDEIG 145

Query: 46  ----------------HVFTAHRLDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAI 89
                                HRLD+ T+G++++         LA+QFE   I + Y AI
Sbjct: 146 LSMVSTGPTEAKLEAPRPGIVHRLDKDTTGLIVVAKDDVTHTGLARQFEHRTIARTYLAI 205

Query: 90  VRGWL-MEEAVLDYPLVEELDKIADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTR 148
           V G        ++  +  +           D   + AVTHY  +  +             
Sbjct: 206 VWGVPDPPRGRIEAAIGRDPRDRQRMAVVPDDRGKRAVTHYEVVEALPA----------- 254

Query: 149 YGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHGDLRQNRSGAEHF----------GLQR 198
             LV  + +TGR HQ+R H  H+ HP++GD  +G                       L R
Sbjct: 255 AALVRFKLETGRTHQIRVHARHIGHPVLGDPTYGGRTIRYGPHTPRRRAFYDQLFARLTR 314

Query: 199 LMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWR 237
             LHA  L   HP TGE L   A L +    AL Q    
Sbjct: 315 QALHAHTLGFRHPRTGEWLEFEAPLPEDMACALEQLRQD 353


>UniRef50_B2A2J2 Pseudouridine synthase n=1 Tax=Natranaerobius thermophilus
           JW/NM-WN-LF RepID=B2A2J2_NATTJ
          Length = 328

 Score =  317 bits (813), Expect = 3e-85,   Method: Composition-based stats.
 Identities = 60/240 (25%), Positives = 112/240 (46%), Gaps = 18/240 (7%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQI------GQHVFTAHRLDR 55
           L+I+Y+DE+L+ VNKP   +VH    +  + +V       Q        +     HRLD+
Sbjct: 91  LDIVYEDEYLLVVNKPRNMVVHPGAGNYRDTMVNALLYHCQNLSDGTSYERPGIVHRLDK 150

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADK 114
            TSG+L++   +E   +L+++ +  ++ + Y A+V G    ++A +D P+  +       
Sbjct: 151 DTSGLLVVAKQNETHDILSEEIKNRRVARTYLALVIGDFSKKKATIDLPIGRDPRNRKKM 210

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
                 G + A+T    L + + P         +   ++   +TGR HQ+R HL+HL +P
Sbjct: 211 AVV--HGGKRAITKVEMLRSFQNPE--------KISYLKCSLETGRTHQIRVHLSHLGYP 260

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           ++GD  +   +  ++      L    LH+  L+ THP   + +   A L    M  +S+ 
Sbjct: 261 LLGDPVY-RGKTGKNVDIDKNLTGQALHSFSLAFTHPVFKKTMVFRAPLPSDMMNLISKL 319


>UniRef50_A3EQJ0 Pseudouridine synthase n=1 Tax=Leptospirillum rubarum
           RepID=A3EQJ0_9BACT
          Length = 339

 Score =  316 bits (812), Expect = 3e-85,   Method: Composition-based stats.
 Identities = 73/252 (28%), Positives = 113/252 (44%), Gaps = 36/252 (14%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQI------------------ 43
           LEILY+DE L+ ++KP G +VH +       +V       Q                   
Sbjct: 95  LEILYEDEDLIVISKPPGLVVHPAPGHSSGTLVNGLLFHFQSQGDEQKKGEPEEEEEAER 154

Query: 44  GQHVFTAHRLDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDY 102
                  HRLD+ TSGV+++G +      L  QF+   + K+Y A+V+G L ++   ++ 
Sbjct: 155 PLRAGLVHRLDQDTSGVMVVGKTESVVLDLMNQFKDRSVSKKYLALVKGILPKKRGEINA 214

Query: 103 PLVEELDKIADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKH 162
           P+            R+D   +P+VT YR L T              Y L+E+   TGR H
Sbjct: 215 PIGRSTHDRKKFTVRQD--GKPSVTRYRVLETYHE----------NYSLLEVTLLTGRTH 262

Query: 163 QLRRHLAHLRHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAG 222
           Q+R H  +L  P++GD+ +G       G E+    R MLHA +LS  HP +   +   A 
Sbjct: 263 QIRVHFRYLGFPLLGDAVYGSK-----GTENKNFPRQMLHAWKLSFQHPSSNSKMEFEAP 317

Query: 223 LDDTWMQALSQF 234
           L   ++ AL + 
Sbjct: 318 LPPDFVSALERL 329


>UniRef50_A1URK8 Pseudouridine synthase n=2 Tax=Bartonella RepID=A1URK8_BARBK
          Length = 336

 Score =  316 bits (810), Expect = 6e-85,   Method: Composition-based stats.
 Identities = 64/254 (25%), Positives = 113/254 (44%), Gaps = 25/254 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG-------QHVFTAHRLD 54
           L IL++D+ ++ VNKP+G +VH    +    +V                 +     HRLD
Sbjct: 80  LHILFEDDHIIVVNKPAGLVVHPGHGNWTGTLVNALIYHCGDSLSGIGGVRRPGIVHRLD 139

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQH----QIQKRYHAIVRGWLMEE-AVLDYPLVEELD 109
           + TSGV+++  +  A + L+ QF  H     + +RYHA++ G       V+   L     
Sbjct: 140 KNTSGVIVVAKNDLAHKGLSAQFSDHGRTGVLDRRYHALIWGSPNRNIGVITASLGRARY 199

Query: 110 KIADKFAREDKG--PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRH 167
               +          + AVTH+  +   +       +      L+E   +TGR HQ+R H
Sbjct: 200 DRTKQAVIHSHNIYARHAVTHFSVIEKYQTCADKIPF----ASLLECRLETGRTHQIRVH 255

Query: 168 LAHLRHPIIGDSKHGDLRQNRSGAEHFGLQ-------RLMLHASQLSLTHPFTGEPLTIH 220
           +AH+ HP++GD+ +G+  + +S      ++       R  LHA+ L+  HP  G  ++  
Sbjct: 256 MAHIGHPLVGDTVYGNAFKTKSNRFDSTIKEAIDLFNRQALHAASLTFEHPAKGNIMSFS 315

Query: 221 AGLDDTWMQALSQF 234
           A L     + ++ F
Sbjct: 316 APLPQDMAELINHF 329


>UniRef50_A7HM17 Pseudouridine synthase n=2 Tax=Thermotogaceae RepID=A7HM17_FERNB
          Length = 314

 Score =  316 bits (810), Expect = 7e-85,   Method: Composition-based stats.
 Identities = 65/240 (27%), Positives = 112/240 (46%), Gaps = 21/240 (8%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ------HVFTAHRLDR 55
           L+I+Y+D  ++ +NK  G + H         +V       +  Q           HRLD+
Sbjct: 79  LDIIYEDRDILVINKQPGIITHPIPSHTSGTIVNGVLYHCKDLQGIGGVLRPGIVHRLDK 138

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADK 114
            TSGV+++  +  A + L +QF+    +K Y  +V+G    +E  ++  +          
Sbjct: 139 DTSGVMVIAKNDLAHQSLTKQFKDRLTEKLYICLVKGVPKRKEGDIEINIARNPVLRVKM 198

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
                +  +PA+THY+ +                  LV   PKTGR HQ+R H+ ++ HP
Sbjct: 199 TVTNSEYGKPALTHYKVVREF----------GDIAALVFAYPKTGRTHQIRVHMKYIGHP 248

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           ++GD  +G  +++    E FG++R MLHA  LS  HP TGE +   A +   + +A+ + 
Sbjct: 249 LMGDEVYGRAKED----EIFGIKRQMLHALSLSFYHPRTGEKVKFIAKIPQDFKEAIQKL 304


>UniRef50_B8FLB4 Pseudouridine synthase n=2 Tax=Bacteria RepID=B8FLB4_DESAA
          Length = 321

 Score =  315 bits (809), Expect = 7e-85,   Method: Composition-based stats.
 Identities = 75/246 (30%), Positives = 110/246 (44%), Gaps = 23/246 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG------QHVFTAHRLDR 55
           L ILY+D  +VAVNKP G +VH +       +V       +        Q     HRLD+
Sbjct: 83  LAILYEDRDIVAVNKPPGMVVHPAPGHSSNTLVNALLAHCKDLSGIGGVQRPGIVHRLDK 142

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADK 114
            TSGV+L   +  A   L++Q  Q +++K Y A+  G + E+  V+D PL          
Sbjct: 143 ETSGVILAAKNDAAHAGLSEQLAQRRVEKFYLALAHGVIKEDTGVIDLPLARHPSDRKRM 202

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
                   + A++ +                      V+++ KTGR HQ+R HLA L HP
Sbjct: 203 HVSTPAKGREALSLWTVKERFL-----------DATYVKVQIKTGRTHQIRVHLAALHHP 251

Query: 175 IIGDSKHGDLRQNRSGA-----EHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQ 229
           +IGD+ +G  ++          +    +R MLHA  +S THP TGE LT+ A L     Q
Sbjct: 252 VIGDTVYGGRKKRGRLPASVLGKAPPPERQMLHAHIVSFTHPVTGEKLTLTAPLPQDMAQ 311

Query: 230 ALSQFG 235
            L    
Sbjct: 312 LLEALR 317


>UniRef50_A3M2Y1 Pseudouridine synthase n=18 Tax=Gammaproteobacteria
           RepID=A3M2Y1_ACIBT
          Length = 350

 Score =  315 bits (809), Expect = 9e-85,   Method: Composition-based stats.
 Identities = 60/247 (24%), Positives = 107/247 (43%), Gaps = 22/247 (8%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG---QHVFTAHRLDRPTS 58
           L+I+Y+DE ++ +NKP G +VH    +    +V                   HR+D+ TS
Sbjct: 115 LDIVYEDEDILVINKPVGMVVHPGAGNTSSTLVNALLYHSPKSAELSRAGLVHRIDKDTS 174

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           G+L++  + EA   L++Q     + + Y  +  G ++    +D P+              
Sbjct: 175 GLLVVAKNLEAQFSLSKQLGDKSVYRIYDLVTYGNIIAGGTIDEPIKRHPVDRVKMAIL- 233

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
             G + AVTHY                   +  V+ + +TGR HQ+R H +++ H ++GD
Sbjct: 234 -PGGRDAVTHYNVKERFR-----------DFTRVQAQLETGRTHQIRVHFSYIGHGLVGD 281

Query: 179 SKHGDLRQNRSGAEHF------GLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALS 232
             + +  +  +GA         G +R  LHA++L L HP TGE +   A   + + Q ++
Sbjct: 282 QVYMNRVRIPAGASELLIETLRGFKRQALHAAKLGLKHPRTGEEMLFEAPWPEDFTQLVN 341

Query: 233 QFGWRGL 239
                  
Sbjct: 342 VLRTENA 348


>UniRef50_C6BSG2 Pseudouridine synthase, RluA family n=1 Tax=Desulfovibrio
           salexigens DSM 2638 RepID=C6BSG2_DESAD
          Length = 549

 Score =  313 bits (804), Expect = 3e-84,   Method: Composition-based stats.
 Identities = 71/269 (26%), Positives = 111/269 (41%), Gaps = 28/269 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTV-----RDQIGQHVFTAHRLDRP 56
           LEI+Y D  +  +NKP+G   H +       +V          RD         HRLD+ 
Sbjct: 94  LEIIYNDGKIAVINKPAGLTTHPAPSCPTGTLVHRMIHHFPEIRDMDEWRPGIVHRLDKF 153

Query: 57  TSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADKF 115
           TSG++ + L+      ++  F   ++ K Y AIV G    E   +D P+           
Sbjct: 154 TSGLITVALNEHDRLAMSTAFADREVNKAYLAIVHGVPKREFGEIDQPMGRHPVHKTKMA 213

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
               KG + A + Y  L +          P  R  LV+++  TGR HQ+R H+AH+ HP+
Sbjct: 214 VVL-KGGRDARSEYEVLWS---------DPAGRASLVKVKIYTGRTHQIRVHMAHIGHPL 263

Query: 176 IGDSKHGDLRQNRSGAEHFGL----QRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
           +GD  +G +       +   L    +R MLHA  LS THP + E L+      + ++  L
Sbjct: 264 VGDQVYGSMPHAIWEQDQPQLAKLAERQMLHAYSLSFTHPDSEEELSFTQAPPEDFINML 323

Query: 232 SQFGWRGLLPENERVEFSAPSGQDGEISS 260
                      ++ V+     G      S
Sbjct: 324 KAL--------DKSVQRVGLIGMPCGGKS 344


>UniRef50_B8CWM0 Pseudouridine synthase n=1 Tax=Halothermothrix orenii H 168
           RepID=B8CWM0_HALOH
          Length = 308

 Score =  312 bits (801), Expect = 6e-84,   Method: Composition-based stats.
 Identities = 64/243 (26%), Positives = 114/243 (46%), Gaps = 25/243 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ------HVFTAHRLDR 55
           L+I+Y+D+ ++ +NK +G +VH +  + +  +V                      HRLD+
Sbjct: 82  LDIIYEDKDILVLNKNAGLVVHPAPGNHENTLVNALIAYCDNLSTISGVNRPGIVHRLDK 141

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADK 114
            TSGV+++  +  + R L +QF+Q + +K Y  +++G L  +E  +D P+  +       
Sbjct: 142 DTSGVMVIAKNDISHRKLVEQFKQRKTKKYYRTLLKGELPYKEGKIDAPIGRDPHDRKKM 201

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
                K  + AVT+++ L                +  VE+E KTGR HQ+R H +++  P
Sbjct: 202 AVTR-KNSKKAVTYFKVLEFFR-----------DHSYVEVELKTGRTHQIRVHFSYMGFP 249

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           ++GDS +G  R            R +LHA +L   HP   + +   A L D + +AL   
Sbjct: 250 VVGDSIYGKKR------NRLQATRQLLHAYRLGFYHPRNDKWVEYKASLPDDFKKALDIL 303

Query: 235 GWR 237
             +
Sbjct: 304 ENK 306


>UniRef50_Q1MQ60 Pseudouridylate synthases, 23S RNA-specific n=1 Tax=Lawsonia
           intracellularis PHE/MN1-00 RepID=Q1MQ60_LAWIP
          Length = 541

 Score =  312 bits (800), Expect = 8e-84,   Method: Composition-based stats.
 Identities = 70/265 (26%), Positives = 112/265 (42%), Gaps = 28/265 (10%)

Query: 1   MLEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVR-----DQIGQHVFTAHRLDR 55
            LEIL+ DE L  +NKP G  VH +   ++  +V           +Q G      HR+D+
Sbjct: 82  FLEILFSDEHLAIINKPPGLTVHPAPSCQESTLVHRLLKYFPKLIEQGGLRPGIVHRIDK 141

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKF 115
            TSG+L + L+ +    L++ F   +I K Y A+V G    E  +  PL  +        
Sbjct: 142 DTSGLLCIALTEDTRLKLSKIFLDRKINKEYLALVHGVPSMEGYIAVPLGRDP--KTKVK 199

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
              +   +PA T +R L   +  V         Y ++ L  +TGR HQ+R H+ H+ HP+
Sbjct: 200 VAVNPKGKPAHTEWRVLHRGKNDV---------YSILALTIQTGRTHQIRVHMKHIGHPL 250

Query: 176 IGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFG 235
           +GD  +     N++        R MLHA +LS  HP TG+ +         ++  +S   
Sbjct: 251 VGDKLYAGGHVNKTFQ----CNRQMLHAWKLSFEHPITGKKMNFLCPPPKDFLDTVSLLE 306

Query: 236 WRGLLPENERVEFSAPSGQDGEISS 260
                           +G  G   +
Sbjct: 307 QE--------PIRIVITGVAGSGKT 323


>UniRef50_B9JRD0 Pseudouridine synthase n=1 Tax=Agrobacterium vitis S4
           RepID=B9JRD0_AGRVS
          Length = 342

 Score =  312 bits (800), Expect = 9e-84,   Method: Composition-based stats.
 Identities = 70/254 (27%), Positives = 111/254 (43%), Gaps = 24/254 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG-------QHVFTAHRLD 54
           L +LY+D+ L+ ++KP+G +VH    +    +V                 +     HRLD
Sbjct: 90  LTVLYEDKDLIVLSKPAGLVVHPGAGNWTGTLVNALIHHCGDSLSGIGGVKRPGIVHRLD 149

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQ----IQKRYHAIVRGWLME-EAVLDYPLVEELD 109
           + TSGV+++  +  A R LA QF  H     +++ Y A+V G        +D  L    D
Sbjct: 150 KETSGVMVVAKNDIAHRHLADQFADHGRSGPLERAYQALVWGRPRGLRGTIDAALGRAGD 209

Query: 110 KIADKFARED-KGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHL 168
           +      RED    + A+THY+ +                  LVE   +TGR HQ+R H+
Sbjct: 210 RTKRTVKREDTDDAREAITHYQVMERYGEKPDATCL----ASLVECRLETGRTHQIRVHM 265

Query: 169 AHLRHPIIGDSKHGDLRQNR-------SGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHA 221
           AH+ HP+IGD ++G   + +       + A      R  LHA  L+  HP TG+ +   A
Sbjct: 266 AHIGHPLIGDPEYGAAFKTKANLLPDAAKAIVTNFHRQALHAYLLAFEHPTTGDVMHFAA 325

Query: 222 GLDDTWMQALSQFG 235
            + D     +    
Sbjct: 326 PIPDDMETIIRALR 339


>UniRef50_B9L028 Pseudouridine synthase n=2 Tax=Thermomicrobia (class)
           RepID=B9L028_THERP
          Length = 322

 Score =  311 bits (798), Expect = 1e-83,   Method: Composition-based stats.
 Identities = 59/240 (24%), Positives = 106/240 (44%), Gaps = 24/240 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQT-----VRDQIGQHVFTAHRLDRP 56
           + ++Y+D+ ++  +KP G + H +       +V         ++ Q        HRLD+ 
Sbjct: 88  IPVIYEDDDIIVFDKPPGIVTHPAPGHEHGTLVNALKAIRPDLQVQPSHRPGIVHRLDKD 147

Query: 57  TSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADKF 115
           TSG+L++  +  A   L +Q++   + K+Y A+V G +  +   +D P+  +  +     
Sbjct: 148 TSGLLVVAKTEAARLALLEQWQSRSVVKKYTALVHGVVEPDSGTIDAPISRDPVERTKMA 207

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
                  +PA+TH+R L                  L+++  +TGR HQ+R H A + HP+
Sbjct: 208 VV--SWGRPAITHFRVLERFRC-----------ATLLDVTIETGRTHQIRVHCAFIGHPV 254

Query: 176 IGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFG 235
           +GDS++G  R          + R  LHA  L   HP TG+ + +   L       L    
Sbjct: 255 VGDSQYGGHRPF-----CVPVPRQFLHARYLRFVHPTTGQAIELETPLPYDLRTVLEALR 309


>UniRef50_A6SXT6 Pseudouridine synthase n=1 Tax=Janthinobacterium sp. Marseille
           RepID=A6SXT6_JANMA
          Length = 342

 Score =  311 bits (797), Expect = 2e-83,   Method: Composition-based stats.
 Identities = 57/239 (23%), Positives = 105/239 (43%), Gaps = 16/239 (6%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQI---GQHVFTAHRLDRPTS 58
           L I+++D  ++ +NKP+G +VH +  +    ++                   HRLD+ TS
Sbjct: 115 LAIVHEDAEMLVINKPAGLVVHPAAGNWSGTLLNGLLHYLPSISGVPRAGIVHRLDKDTS 174

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           G++++  +  A   L +Q +   +++ Y A+V G       +D  +             E
Sbjct: 175 GLMVVAKTLIAHTDLVRQLQARTVKREYLALVWGTPNITGKIDASIGRHARDRIKMAVSE 234

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
           +   +PAVTH++ LAT       G        L+    +TGR HQ+R H+  +   ++GD
Sbjct: 235 NLTAKPAVTHFQRLAT-------GMLDGRPVSLMLCRLETGRTHQIRVHMQSIGFALVGD 287

Query: 179 SKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWR 237
             +G               R  LHA +L L HP +GE +   + L   + + +++ G +
Sbjct: 288 GLYGKQHLTTV------FPRQALHARRLGLIHPVSGEAVEWSSELPQDFAELIARAGIK 340


>UniRef50_A7HV45 Pseudouridine synthase n=56 Tax=Alphaproteobacteria
           RepID=A7HV45_PARL1
          Length = 482

 Score =  310 bits (796), Expect = 2e-83,   Method: Composition-based stats.
 Identities = 66/257 (25%), Positives = 108/257 (42%), Gaps = 32/257 (12%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQI-------GQHVFTAHRLD 54
           LEI+Y+D  L+ V KP+G +VH +  + D  +V                 +     HRLD
Sbjct: 226 LEIVYEDADLIVVMKPAGLVVHPAPGNPDMTLVNALVAHCGETLSGIGGEKRPGIVHRLD 285

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQH----QIQKRYHAIVRGWL-MEEAVLDYPLVEELD 109
           + TSG++++  +  A + L+ QF  H    ++ + Y A+  G     +  +D  +     
Sbjct: 286 KETSGLMVVAKTDRAHQGLSAQFAAHGRDGKLTRAYTALTWGVPQTRKGTVDANIARSSH 345

Query: 110 KIADKFAREDKG----PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLR 165
             +      D+G     + A+THY              Y       VE   +TGR HQ+R
Sbjct: 346 NRSKMATVRDRGEETGGRIAITHYTV---------KTDYADGLVAEVECRLETGRTHQIR 396

Query: 166 RHLAHLRHPIIGDSKHGDLRQNRSG-------AEHFGLQRLMLHASQLSLTHPFTGEPLT 218
            H+  L HP++GD+ +G   ++R         A    L R  LHA  L   HP  GE ++
Sbjct: 397 VHMTALGHPLLGDATYGTGMKSRKSKLSPEAQAALERLNRQALHAHHLGFEHPVAGEKMS 456

Query: 219 IHAGLDDTWMQALSQFG 235
             A L +   + +    
Sbjct: 457 FDAPLPEDMQELVRALE 473


>UniRef50_C0BNA6 Pseudouridine synthase n=7 Tax=Bacteroidetes RepID=C0BNA6_9BACT
          Length = 379

 Score =  310 bits (796), Expect = 3e-83,   Method: Composition-based stats.
 Identities = 59/254 (23%), Positives = 106/254 (41%), Gaps = 28/254 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQI-----GQHVFTAHRLDRP 56
           L+++Y+D  L+ VNKP G +VH    +    ++       +       +     HR+D+ 
Sbjct: 132 LDVVYEDSDLMVVNKPPGMVVHPGHGNYSGTLINALLFHVKDLPLNADERPGLVHRIDKD 191

Query: 57  TSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADKF 115
           TSG+L++  +++A   LA+QF     ++ Y AIV G + EE   +   +           
Sbjct: 192 TSGLLVVAKTAKAMTHLAKQFFDKTSEREYVAIVWGNVEEEQGTVRGHIGRHPKNRLQMA 251

Query: 116 AREDKG-PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
              D    + AVTHY+ +  +               LV    +TGR HQ+R H+ H+ H 
Sbjct: 252 VFPDGDQGKEAVTHYKVMERLGY-----------VTLVSCVLETGRTHQIRAHMKHIGHT 300

Query: 175 IIGDSKHGDLRQNRSGA----------EHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLD 224
           +  D ++G  +  +                 L R  LHA  L   HP +GE +  +  + 
Sbjct: 301 LFNDERYGGEKILKGTTFTKYKQFVDNAFKALPRQALHAKTLGFVHPSSGELMRFNTPIP 360

Query: 225 DTWMQALSQFGWRG 238
           +  +  + ++    
Sbjct: 361 EDMVLCIEKWRAYA 374


>UniRef50_C6WV38 Pseudouridine synthase n=3 Tax=Proteobacteria RepID=C6WV38_METML
          Length = 368

 Score =  310 bits (795), Expect = 3e-83,   Method: Composition-based stats.
 Identities = 66/244 (27%), Positives = 105/244 (43%), Gaps = 23/244 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG---QHVFTAHRLDRPTS 58
           L+I+Y+D+ ++ VNKP+G +VH +  + D  ++                   HRLD+ TS
Sbjct: 90  LDIVYEDDHILVVNKPAGMVVHPAAGNWDGTLLNALLFHAPQLHDVPRAGIVHRLDKETS 149

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           G+L++  +  A   L +Q +   +++ Y AIV G L    V+D PL  +           
Sbjct: 150 GLLVVAKTLNAQTHLVRQLQARTVKREYRAIVWGQLWRNGVVDQPLGRDPRSRTKMAI-- 207

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
           ++  +PA+T Y  L    +              +    +TGR HQ+R H+ HL+ P++GD
Sbjct: 208 NRMGKPAITRYEILERFSVQ-----------TYLRCNLETGRTHQIRVHMQHLKAPLVGD 256

Query: 179 SKHGDLRQNRSGAEHFGL-------QRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
             +G        A    L        R  LHA +L L HP T E +     L D     L
Sbjct: 257 PVYGFRGIVPIRAMTQTLRDAVSQFHRQALHAIKLGLVHPATNEFMEWQIELADDMKVLL 316

Query: 232 SQFG 235
               
Sbjct: 317 EAMR 320


>UniRef50_B6AN83 Pseudouridine synthase n=2 Tax=Leptospirillum RepID=B6AN83_9BACT
          Length = 340

 Score =  309 bits (793), Expect = 6e-83,   Method: Composition-based stats.
 Identities = 71/252 (28%), Positives = 113/252 (44%), Gaps = 36/252 (14%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQI------------------ 43
           LEILY+D+ L+ ++KP G +VH +       +V       Q                   
Sbjct: 95  LEILYEDDDLIVISKPPGLVVHPAPGHASGTLVNGLLFHFQSQGDEQKKGEPEEEEEAER 154

Query: 44  GQHVFTAHRLDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDY 102
                  HRLD+ TSGV+++G S      L  QF+   + K+Y A+V+G L ++   ++ 
Sbjct: 155 PLRAGLVHRLDQDTSGVMVVGKSETVVLDLMNQFKDRSVSKKYLALVKGILPKKRGEINA 214

Query: 103 PLVEELDKIADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKH 162
           P+            R+D   +P++T YR L T              Y L+E+   TGR H
Sbjct: 215 PIGRSTHDRKKFAVRQD--GKPSLTRYRVLETYHE----------NYSLLEVTLLTGRTH 262

Query: 163 QLRRHLAHLRHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAG 222
           Q+R H  HL  P++GD+ +G       G E+    R MLHA +L+  HP +   +   A 
Sbjct: 263 QIRVHFRHLGFPLLGDAVYGSK-----GMENRNFPRQMLHAWKLAFQHPRSAAKMEFEAP 317

Query: 223 LDDTWMQALSQF 234
           L   ++ A+ + 
Sbjct: 318 LPPDFVSAMKRL 329


>UniRef50_C7RM94 Pseudouridine synthase n=11 Tax=Proteobacteria RepID=C7RM94_9PROT
          Length = 375

 Score =  309 bits (793), Expect = 7e-83,   Method: Composition-based stats.
 Identities = 58/241 (24%), Positives = 106/241 (43%), Gaps = 18/241 (7%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG---QHVFTAHRLDRPTS 58
           L I+++D+ L+ ++K +G +VH    +    ++                   HRLD+ T+
Sbjct: 107 LRIVFEDDTLIVLDKQAGLVVHPGSGNWRGTLLNGLLHHAPQLARVPRAGIVHRLDKDTT 166

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           G++++  + EA   L +Q +   +++ Y A+VRG +    ++D P+              
Sbjct: 167 GLMVVAKTLEAQTDLVRQLQARSVKRCYQALVRGIVEGAGIVDAPIGRHPTVRTRMAVV- 225

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
             G +PA THYR L                  L+E   +TGR HQ+R H+  + HP++GD
Sbjct: 226 -SGGRPARTHYRVLERFVA-----------CTLIECALETGRTHQIRVHMTSIAHPLVGD 273

Query: 179 SKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWRG 238
             +G         +     R  LHA +L+L HP +G+ +   +G+       + +     
Sbjct: 274 PIYGGGAS--RVPQGAVFPRQALHACRLALVHPASGKAMLWRSGVPADMAALIDRLRLES 331

Query: 239 L 239
           L
Sbjct: 332 L 332


>UniRef50_C8QZ10 Pseudouridine synthase n=1 Tax=Desulfurivibrio alkaliphilus AHT2
           RepID=C8QZ10_9DELT
          Length = 324

 Score =  309 bits (792), Expect = 7e-83,   Method: Composition-based stats.
 Identities = 73/238 (30%), Positives = 110/238 (46%), Gaps = 21/238 (8%)

Query: 5   LYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ------HVFTAHRLDRPTS 58
           LY+DE ++ + KP G +VH +   R   +V       +              HRLD+ TS
Sbjct: 96  LYEDEDILVLVKPPGLVVHPADGHRQGTLVHGLLHHCRNLSGISGQLRPGIVHRLDKDTS 155

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADKFAR 117
           G L++  +  A   L QQF+  +++K Y A++RG L E+   +  P+            R
Sbjct: 156 GCLVVAKNDLAHHNLVQQFKGREVEKTYQALLRGILAEDTGQVVLPIGRHPVHRKKMAVR 215

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
            + G + AVTH+R               +  Y LVEL  +TGR HQ+R H+A L HP+ G
Sbjct: 216 RE-GGREAVTHWRVRQRF----------SAGYTLVELLLETGRTHQIRVHMAALGHPLAG 264

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFG 235
           D  +G    N      +G+ R  LHA +L+  HP +G  LT  A L      +L +  
Sbjct: 265 DRLYGR---NPEKDMPYGIDRQWLHAWRLAFNHPRSGRRLTFTAPLWVDLQASLDRLR 319


>UniRef50_C8NEP8 Pseudouridine synthase n=1 Tax=Granulicatella adiacens ATCC 49175
           RepID=C8NEP8_9LACT
          Length = 308

 Score =  309 bits (792), Expect = 8e-83,   Method: Composition-based stats.
 Identities = 67/240 (27%), Positives = 110/240 (45%), Gaps = 28/240 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ--------HVFTAHRL 53
           L+I+++D+ L+ VNKPSG +VH S       +V                        HR+
Sbjct: 80  LDIVFEDDSLIVVNKPSGMVVHPSKGHYSGTLVNALLYHSNSLSDSTSEEIYRPGLVHRI 139

Query: 54  DRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIA 112
           D+ TSG+L++  +++  + LA+Q  ++++ + Y AIV G    E  V+D PL        
Sbjct: 140 DKDTSGLLVIAKNNDVHQKLAEQIAENKMNREYIAIVDGHFAHETGVVDAPLSRHQTNRL 199

Query: 113 DKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLR 172
            +    +KG + A+TH+  L +            + Y LV    +TGR HQ+R H+  ++
Sbjct: 200 KRVV--EKGGKNAITHFEVLDSF-----------SDYSLVSCRLETGRTHQIRAHMEFIK 246

Query: 173 HPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALS 232
           HPI+ D  +    +N +           LHA  LS THP TGE L         + + + 
Sbjct: 247 HPIVNDPLYHPKGKNATEF------GQFLHARTLSFTHPLTGETLNFQVEPPKEFAEFIQ 300


>UniRef50_B8E0R4 Pseudouridine synthase n=1 Tax=Dictyoglomus turgidum DSM 6724
           RepID=B8E0R4_DICTD
          Length = 303

 Score =  308 bits (791), Expect = 1e-82,   Method: Composition-based stats.
 Identities = 60/243 (24%), Positives = 116/243 (47%), Gaps = 26/243 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ------HVFTAHRLDR 55
           +EI+Y+DE +V +NKP G +VH +    ++ +V     R +              HRLD+
Sbjct: 79  IEIVYEDEDMVIINKPKGMVVHPAHGHYNDTLVNALLYRVKDLSGIGGELRPGIIHRLDK 138

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADK 114
            T+G+L++  +  + + L++Q +   +++ Y A+  G +  EE  ++ P+          
Sbjct: 139 DTTGLLIIAKNDLSHQKLSEQLKNRTLRRTYWALCEGEIPWEEKRIEAPIGRHPINRKKM 198

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
                   + A+T+++ L   +            Y L+  + +TGR HQ+R H++HL  P
Sbjct: 199 AIV--PYGKIAITNFKVLERFK-----------GYTLISADLETGRTHQIRVHISHLGFP 245

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           I+GD  +G         + FG++  +LHA ++S  HP  G P+     L + + + L+  
Sbjct: 246 IVGDEVYG------RIDKKFGVKGQLLHAKKVSFIHPTKGIPMEFEIDLPEEFKKVLTLL 299

Query: 235 GWR 237
             +
Sbjct: 300 REK 302


>UniRef50_D1RB31 Pseudouridine synthase n=1 Tax=Parachlamydia acanthamoebae str.
           Hall's coccus RepID=D1RB31_9CHLA
          Length = 319

 Score =  308 bits (790), Expect = 1e-82,   Method: Composition-based stats.
 Identities = 72/253 (28%), Positives = 106/253 (41%), Gaps = 29/253 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG--------QHVFTAHRL 53
           L ILY+DE L+ +NKP G +VH +  +     V                        HRL
Sbjct: 87  LNILYEDEHLLIINKPVGMVVHPAPGNWTGTFVNALLYHCGYSLSDASVDSIRPGIVHRL 146

Query: 54  DRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIAD 113
           D+ TSGVL+   +    + L + F   Q+ K Y AI  G       L++P+         
Sbjct: 147 DKETSGVLVAAKTLSVQQKLMELFAARQVYKEYWAICLGNPGNC-ELNWPIGRHPIHRKQ 205

Query: 114 KFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
              RED   + A+T    L                  L +L   TGR HQ+R HL H  H
Sbjct: 206 MTVRED--GKEALTFCETLE-----------VGNEICLAKLILSTGRTHQIRVHLKHKGH 252

Query: 174 PIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           PI+GDS +G  + N      +  +R MLHA +L+  HP T + + + A L     + L +
Sbjct: 253 PILGDSIYGSKQVN----MRYRAERQMLHARKLAFIHPITQQKIEVEAPLPADMEECLRK 308

Query: 234 FGWRGLLPENERV 246
              + +L   E+ 
Sbjct: 309 ---KAMLERTEKC 318


>UniRef50_Q49WX8 Pseudouridine synthase n=1 Tax=Staphylococcus saprophyticus subsp.
           saprophyticus ATCC 15305 RepID=Q49WX8_STAS1
          Length = 305

 Score =  307 bits (789), Expect = 2e-82,   Method: Composition-based stats.
 Identities = 61/241 (25%), Positives = 106/241 (43%), Gaps = 27/241 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQI------GQHVFTAHRLDR 55
           L+I Y+D+ +  V KP G +VH S       +V     + +              HR+D+
Sbjct: 81  LDIYYEDDDVAIVYKPKGMVVHPSAGHYTGTLVNGLMYQMKNLSGINGEIRPGIVHRIDK 140

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADK 114
            TSG+L++  +  A R L  Q     + ++Y A+V G +  +   +D P+    +     
Sbjct: 141 DTSGLLMVAKNDVAHRSLVDQLVNKTVTRKYVALVHGKIPHDYGTVDAPIGRNKNDRQSM 200

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
              +D   + AVTH+  L               +Y L+E + +TGR HQ+R H+ ++ +P
Sbjct: 201 DVVDD--GKEAVTHFNVLEHF-----------NKYTLIECQLETGRTHQIRVHMKYIGYP 247

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           ++GD K+G  +          +    LHA  +   HP T E +     L + + Q LS+ 
Sbjct: 248 LVGDPKYGPKK-------TLDIGGQALHAGIIGFEHPVTHEYIEKSTALPEDFEQLLSEL 300

Query: 235 G 235
            
Sbjct: 301 R 301


>UniRef50_Q2W2D5 Pseudouridine synthase n=39 Tax=Bacteria RepID=Q2W2D5_MAGSA
          Length = 505

 Score =  307 bits (789), Expect = 2e-82,   Method: Composition-based stats.
 Identities = 63/249 (25%), Positives = 106/249 (42%), Gaps = 25/249 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG-------QHVFTAHRLD 54
           L ++Y+DE L+ ++KP+G +VH +  + DE +V                 +     HR+D
Sbjct: 265 LTVVYEDEDLIVIDKPAGMVVHPAPGNPDETLVNALLAHCGESLAGIGGVKRPGIVHRID 324

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIAD 113
           + TSG+L+   +  A R LA QF  H +++ Y A+V G     +  ++  +    +    
Sbjct: 325 KDTSGLLVAAKTDAAHRGLATQFAAHTLERAYWALVWGTPSPRQGEIEGNIGRNPNDRKK 384

Query: 114 KFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
               +  G +PA+T YR L +                LVE    TGR HQ+R H+    H
Sbjct: 385 MAVVKS-GGKPALTRYRVLKSF---------AGGAVSLVECRLATGRTHQIRVHMTTQGH 434

Query: 174 PIIGDSKHGDLRQNRS-------GAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDT 226
           P++GD  +G +R ++                R  LHA  L  +HP  G  +   +G+   
Sbjct: 435 PLVGDPVYGRIRGHKGVVLPPEVKTALIQFPRQALHAYLLGFSHPTKGYDVRFESGMPLD 494

Query: 227 WMQALSQFG 235
               +    
Sbjct: 495 INALMQILE 503


>UniRef50_C4FWV7 Pseudouridine synthase n=2 Tax=Firmicutes RepID=C4FWV7_9FIRM
          Length = 309

 Score =  307 bits (788), Expect = 2e-82,   Method: Composition-based stats.
 Identities = 66/242 (27%), Positives = 111/242 (45%), Gaps = 21/242 (8%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG-------QHVFTAHRLD 54
           L+I+Y+DE ++ +NKP+G +VH S       +V                       HR+D
Sbjct: 81  LDIIYEDEDILVINKPAGLVVHPSKGHLKGTLVNGLLHYLNGNLSTGSDFYRPGIVHRID 140

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIAD 113
           + TSG+L++   + A + LA Q   H +++ Y A+V G +   +  ++ PL  +      
Sbjct: 141 KDTSGLLVVAKHNAAHQALADQLLNHDMRRSYIALVHGQVKAPQGTIEAPLQRDPANRLR 200

Query: 114 KFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
                 K  + A+T ++ +   E              L++LE +TGR HQ+R HL  + H
Sbjct: 201 WTV--AKEGKYALTRFQVMENFE-----------NATLLDLELETGRTHQIRVHLEFIGH 247

Query: 174 PIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           P++GD  +     +  G+    +   +LHA  L L HP +GE L   A L   + +AL Q
Sbjct: 248 PLVGDPVYRKGLDHIKGSLVHDMTGQLLHAYALKLQHPRSGEWLEFKAPLPRRFEEALDQ 307

Query: 234 FG 235
             
Sbjct: 308 LR 309


>UniRef50_P74346 Uncharacterized RNA pseudouridine synthase slr1629 n=19
           Tax=Bacteria RepID=Y1629_SYNY3
          Length = 327

 Score =  307 bits (788), Expect = 2e-82,   Method: Composition-based stats.
 Identities = 69/246 (28%), Positives = 110/246 (44%), Gaps = 24/246 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG------QHVFTAHRLDR 55
           L+ILY+DE L+ +NKP+G +VH      D  VV                Q     HRLD+
Sbjct: 98  LDILYEDEQLIIINKPAGLVVHPGPGHPDGTVVNALLAHCPDLAGIGGVQRPGIVHRLDK 157

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADK 114
            T+G +++  +  A   L  Q ++   ++ Y  IV G   E +  ++ P+          
Sbjct: 158 DTTGAMVVAKTELALHNLQVQLKEKTARRLYWGIVYGSPKEIQGTVNLPVGRHPGDRQKM 217

Query: 115 -FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
                +KG + AVTH+R L  +             +  +E + +TGR HQ+R H   + H
Sbjct: 218 GIVPVEKGGREAVTHWRLLERI-----------GNHSWLEFQLETGRTHQIRVHSKQMGH 266

Query: 174 PIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           P++GD+ +        G+ +  L    LHA QLSL HP +GE +T  A +   + + L  
Sbjct: 267 PLVGDNLY-----TSPGSVNVNLPGQALHAHQLSLIHPVSGEIITAIAPMPAHFEKLLVY 321

Query: 234 FGWRGL 239
              R  
Sbjct: 322 LRQRIP 327


>UniRef50_C4XSN0 Ribosomal large subunit pseudouridine synthase D/dephospho-CoA
           kinase n=1 Tax=Desulfovibrio magneticus RS-1
           RepID=C4XSN0_DESMR
          Length = 554

 Score =  307 bits (788), Expect = 2e-82,   Method: Composition-based stats.
 Identities = 76/269 (28%), Positives = 118/269 (43%), Gaps = 28/269 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQI-----GQHVFTAHRLDRP 56
           L++LY D  ++ +NKP+G  +H +    D  +V              G      HRLD+ 
Sbjct: 93  LKLLYLDGDVLVLNKPAGLTIHPASSQPDGTLVNRLLHHFPDMRAMAGDRPGIVHRLDKD 152

Query: 57  TSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADKF 115
           TSG+LL+  +  A   LA  F + ++ K Y A+V G     + V++ P+  +        
Sbjct: 153 TSGLLLVAQTESARLALAADFAERRVAKTYLALVHGRPERSDGVIELPVGRDPKHPTKMA 212

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
               KG + A + ++   T          P     L+E+   TGR HQ+R H+A + HPI
Sbjct: 213 VV-AKGGREAKSSWKLAWT---------APDGTASLLEVAIATGRTHQIRVHMAAMGHPI 262

Query: 176 IGDSKHGDLRQ----NRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
           +GD+ +G  +      R GA     +R MLHA +L+ +HP TGE L+        +    
Sbjct: 263 VGDAVYGARQHSDWTRRGGAMARLAKRQMLHAWKLAFSHPGTGEELSFCQPPPADF---- 318

Query: 232 SQFGWRGLLPENERVEFSAPSGQDGEISS 260
               WR LL    R +     G  G   S
Sbjct: 319 ----WRLLLMLGRRCQRVGLVGMPGCGKS 343


>UniRef50_A5WFS2 Pseudouridine synthase n=3 Tax=Psychrobacter RepID=A5WFS2_PSYWF
          Length = 420

 Score =  307 bits (787), Expect = 3e-82,   Method: Composition-based stats.
 Identities = 64/245 (26%), Positives = 109/245 (44%), Gaps = 24/245 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG---QHVFTAHRLDRPTS 58
           L+I+Y+D+ ++ +NKP G +VH    +    +V                   HR+D+ TS
Sbjct: 181 LDIIYEDDSVIVINKPVGMVVHPGAGNWSGTLVNGLLYHYPNQAHLPRAGLVHRIDKNTS 240

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGW---LMEEAVLDYPLVEELDKIADKF 115
           G+L++G +  A   L +Q +   + + Y  +V G    L  +  +D P+     +     
Sbjct: 241 GLLVIGKTKAAQLELQEQLKDKSVYRHYQCVVAGDAPSLARQRTIDAPIGRHRTQRTKMT 300

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
                  + A+TH          +      +  Y L+++  +TGR HQ+R HL+H+ HPI
Sbjct: 301 VT--STGKTAITH----------IMKITPLSDTYSLLDVRLETGRTHQIRVHLSHIGHPI 348

Query: 176 IGDSKHGDLRQNRSG------AEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQ 229
           IGD  +G+ +Q R+G             R  LHA +L   HP TGE + + A L    ++
Sbjct: 349 IGDDIYGNRQQLRAGLTPEQRQAIQSFPRQALHAYKLGFIHPETGESIELTAPLPQDIVE 408

Query: 230 ALSQF 234
                
Sbjct: 409 LAHTL 413


>UniRef50_C8X1I9 Pseudouridine synthase, RluA family n=1 Tax=Desulfohalobium
           retbaense DSM 5692 RepID=C8X1I9_DESRD
          Length = 547

 Score =  307 bits (787), Expect = 3e-82,   Method: Composition-based stats.
 Identities = 72/268 (26%), Positives = 114/268 (42%), Gaps = 27/268 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQ-----IGQHVFTAHRLDRP 56
           +E++Y D  +V VNK +G  VH         +V              G+     HRLD+ 
Sbjct: 91  VEVVYSDPDVVVVNKAAGVTVHPGTGCESGTLVHHLAALYPELARFDGERPGVVHRLDKD 150

Query: 57  TSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFA 116
           TSG+L + L+  A   L + F + ++ K Y  +V G    E  +D+PL  +         
Sbjct: 151 TSGLLTVALNESARLALTRSFARREVDKEYLTLVHGRPEAEGTVDHPLGRDPQSKIRMAV 210

Query: 117 REDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPII 176
              +G + A+T ++ + T          P  R  L+ +   TGR HQ+R H+A+L  P++
Sbjct: 211 VP-RGGKEALTRFKRVWT---------SPDGRVSLLRVRILTGRTHQIRVHMAYLGFPLV 260

Query: 177 GDSKHGDLRQNRSGAEHFGLQRL----MLHASQLSLTHPFTGEPLTIHAGLDDTWMQALS 232
           GD+ +G   Q         L RL    MLHA +L+  HP +G  +     +         
Sbjct: 261 GDALYGPQAQAAFQRSRPLLARLAKHHMLHAWRLAFPHPRSGRMVCCEQAMPKAM----- 315

Query: 233 QFGWRGLLPENERVEFSAPSGQDGEISS 260
              WR +L    RV+    +G  G   S
Sbjct: 316 ---WRLVLGCGRRVQRVGLTGMPGCGKS 340


>UniRef50_C8PVB8 Pseudouridine synthase n=2 Tax=Moraxellaceae RepID=C8PVB8_9GAMM
          Length = 380

 Score =  307 bits (787), Expect = 3e-82,   Method: Composition-based stats.
 Identities = 67/248 (27%), Positives = 106/248 (42%), Gaps = 27/248 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG---QHVFTAHRLDRPTS 58
           L+ILY+DE ++ +NKP G +VH    +    +V                   HR+D+ TS
Sbjct: 143 LDILYEDEAVLVINKPVGLVVHPGAGNGSGTLVNALLFHYPDSRTLPRAGLVHRIDKETS 202

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIV---RGWLMEEAVLDYPLVEELDKIADKF 115
           G++++   S++   L  Q +   + + Y AIV      L     +D P+     +     
Sbjct: 203 GLMVIAKDSQSQLHLINQLKDKSVYRLYQAIVLASAAELARHRTIDAPIGRHPTQRTKMA 262

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
                  +PAVTH   +             +    LV +  +TGR HQ+R HL++L  P+
Sbjct: 263 VVSS--GKPAVTHLEKI----------TAISDAVSLVSVRLETGRTHQIRVHLSNLGFPL 310

Query: 176 IGDSKHGDLRQNRSGAEHF---------GLQRLMLHASQLSLTHPFTGEPLTIHAGLDDT 226
           +GD  +G  R+N    +             QR  LHA +L   HP TGEP+ + A L + 
Sbjct: 311 LGDPLYGAARKNAILLKTLDDDQKHIVQQFQRQALHAYELGFIHPKTGEPIKVQARLPED 370

Query: 227 WMQALSQF 234
             Q L   
Sbjct: 371 MQQLLDTL 378


>UniRef50_Q3A0C2 Pseudouridine synthase n=13 Tax=Bacteria RepID=Q3A0C2_PELCD
          Length = 326

 Score =  306 bits (784), Expect = 7e-82,   Method: Composition-based stats.
 Identities = 71/253 (28%), Positives = 111/253 (43%), Gaps = 23/253 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ------HVFTAHRLDR 55
           L ILY+D  L+ ++KP G +VH +       +V       Q              HRLD+
Sbjct: 81  LVILYEDRHLIVIDKPPGMVVHPAPGHYQGTLVNALLHHCQDLSGIGGELRPGIVHRLDK 140

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADK 114
            TSGV++   +  A + LA QF+ H I +RY A++ G L  +   +D P+          
Sbjct: 141 DTSGVMVATKTDSAHQSLAAQFKAHSITRRYIALIHGVLTGDRGSIDRPIGRHPTHRKKM 200

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
                +  + AVTH+R L   +           R  LVEL  +TGR HQ+R H +  +HP
Sbjct: 201 STTC-RTGRHAVTHWRVLRRFD---------DDRLTLVELALETGRTHQIRVHFSEQQHP 250

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQ------RLMLHASQLSLTHPFTGEPLTIHAGLDDTWM 228
           ++GD  +G   + ++  +   L+      R  LHA  L   HP TG+ L   + L +   
Sbjct: 251 LLGDPVYGGSGRLKTINDPQLLKRAKALGRQALHARLLGFQHPETGKYLEFSSPLPEDLR 310

Query: 229 QALSQFGWRGLLP 241
             +     +   P
Sbjct: 311 SVIDYLTEKYGQP 323


>UniRef50_D1PCC3 Pseudouridine synthase n=1 Tax=Prevotella copri DSM 18205
           RepID=D1PCC3_9BACT
          Length = 387

 Score =  305 bits (783), Expect = 7e-82,   Method: Composition-based stats.
 Identities = 65/267 (24%), Positives = 110/267 (41%), Gaps = 33/267 (12%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKV--VVMQTVRDQI-----GQHVFTAHRLD 54
           + ++Y+D+ L+ VNK +G +VH    +    +   V   +RD          V   HR+D
Sbjct: 131 INVVYEDDQLMVVNKEAGMVVHPGAGNFHGTLIQAVAWHLRDMPEFDANDPEVGLVHRID 190

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRG-WLMEEAVLDYPLVEELDKIAD 113
           + TSG+L++  +  A   L +QF      + Y+A+V G  + +E  ++  +  +      
Sbjct: 191 KDTSGLLVVAKTPTAKNALGKQFFNKTTHRSYNALVWGNIVEDEGRIEGNIGRDPKNRLR 250

Query: 114 KFA-REDKG-PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHL 171
                 D G  + AVTHY+ L                  LV+   +TGR HQ+R H+ H+
Sbjct: 251 MKVFDPDSGIGKTAVTHYKVLERFGYT-----------TLVQCVLETGRTHQIRAHMKHI 299

Query: 172 RHPIIGDSKHGDLRQNRSGAEH----------FGLQRLMLHASQLSLTHPFTGEPLTIHA 221
            HP+  D  +G     R                   R  LHA  L   HP T + +   +
Sbjct: 300 GHPLFMDETYGGTEILRGQRSSSYKAFIQNCFKLCPRQALHAKTLGFVHPTTKQQMDFDS 359

Query: 222 GLDDTWMQALSQFGWRGLLPENERVEF 248
              + + Q + +  WRG +    +  F
Sbjct: 360 EWPNDFRQLIEK--WRGFIAGTTQDTF 384


>UniRef50_A9BMW0 Pseudouridine synthase n=10 Tax=Comamonadaceae RepID=A9BMW0_DELAS
          Length = 356

 Score =  305 bits (783), Expect = 8e-82,   Method: Composition-based stats.
 Identities = 66/242 (27%), Positives = 104/242 (42%), Gaps = 25/242 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG---QHVFTAHRLDRPTS 58
           L+++Y+DE L+ VNKP+G +VH +  +    ++     RD            HRLD+ TS
Sbjct: 125 LDVVYEDEHLLVVNKPAGLVVHPAPGNWTGTLLNGLLGRDPKAREVPRAGIVHRLDKDTS 184

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGW--LMEEAVLDYPLVEELDKIADKFA 116
           G++++  S  A   L        + ++Y A+        +   +D P+  +         
Sbjct: 185 GLMVVARSRAAMDALVAMIAARDVSRQYLALAHKAWGPRKHREVDAPIGRDPRNRLRMAV 244

Query: 117 RE--DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
            +      + A T    LA                 LV     TGR HQ+R H+A L HP
Sbjct: 245 VDLAQHAGKTARTDIDLLA-----------GNEEVSLVRCTLHTGRTHQIRVHMASLGHP 293

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           ++ D+ +G         E  G+ R  LHA +L+ THP TG+ L + A L     QAL  +
Sbjct: 294 LVADAVYGGK-------EAGGMARQALHAFRLAFTHPMTGQALVLRAPLPPDMAQALENW 346

Query: 235 GW 236
           G 
Sbjct: 347 GL 348


>UniRef50_A5EX53 Pseudouridine synthase n=1 Tax=Dichelobacter nodosus VCS1703A
           RepID=A5EX53_DICNV
          Length = 322

 Score =  305 bits (782), Expect = 1e-81,   Method: Composition-based stats.
 Identities = 69/247 (27%), Positives = 110/247 (44%), Gaps = 22/247 (8%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHV---FTAHRLDRPTS 58
           L ILY D+ ++ +NKP+G +VH +  + D  ++          +H+      HRLD+ TS
Sbjct: 86  LNILYADDDIIVINKPAGLVVHPAVGNHDNTLLNALLYHFPQTKHLPRSGIVHRLDKDTS 145

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           G +++  S+ A   L +Q +   + + Y A+V G++     +D P+            R 
Sbjct: 146 GAMVIAHSARAHTDLVRQLQNRSMGRIYLALVYGYITAGDTIDLPIGRHAKDRLKMAVRP 205

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
           D   +PA+THYR                    L+ ++ +TGR HQ+R HL+H RHP++GD
Sbjct: 206 D--GKPAITHYRIEERW-----------QTLTLLRVQLETGRTHQIRVHLSHHRHPLVGD 252

Query: 179 SKHGDLRQNRSGAEHFG------LQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALS 232
             +G      S              R  LHA +L L HP T E +   A L D   Q  +
Sbjct: 253 KLYGARPFLASSLTELQRQALAEFPRQALHAVELHLHHPATNEIMRFTAPLPDDMTQLFT 312

Query: 233 QFGWRGL 239
               +  
Sbjct: 313 ILRAQNP 319


>UniRef50_B5YKV0 Pseudouridine synthase n=1 Tax=Thermodesulfovibrio yellowstonii DSM
           11347 RepID=B5YKV0_THEYD
          Length = 315

 Score =  305 bits (782), Expect = 1e-81,   Method: Composition-based stats.
 Identities = 61/242 (25%), Positives = 110/242 (45%), Gaps = 18/242 (7%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRD------QIGQHVFTAHRLDR 55
           ++++Y+D++L+ ++KP+G +V+      D  ++                      HRLD+
Sbjct: 82  IQVIYKDDYLIVLSKPAGMVVYPCAGHPDGTLMNALAYHVKKLANVGAPFRPGIVHRLDK 141

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKF 115
            TSGV+++ L  E    L + F++ +I+K Y A+V G L     +  P+   +       
Sbjct: 142 DTSGVMVVALDDETYYKLVEAFKKREIKKEYLALVYGQLRGSGKITTPVGRAIYDRKKMS 201

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
            +  K  + A+T +  +   +            Y  ++++  TGR HQ+R H + + HP+
Sbjct: 202 IK-SKKAKEAITEWEVIKNFK-----------NYTFLKVKILTGRTHQIRVHFSSIGHPV 249

Query: 176 IGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFG 235
           IGD  +G       G +   + R MLHA ++ L HP T + L   A L D     L+   
Sbjct: 250 IGDKTYGRKTYIEIGNKKIPVSRQMLHAHKIELIHPITEKLLQFEASLPDDIQYILNILE 309

Query: 236 WR 237
            R
Sbjct: 310 DR 311


>UniRef50_Q3AVX8 Pseudouridine synthase n=40 Tax=cellular organisms
           RepID=Q3AVX8_SYNS9
          Length = 339

 Score =  304 bits (781), Expect = 1e-81,   Method: Composition-based stats.
 Identities = 63/244 (25%), Positives = 100/244 (40%), Gaps = 23/244 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ------HVFTAHRLDR 55
           L++L++DE ++ +NK +G  VH +  ++D  +V                      HRLD+
Sbjct: 106 LDVLFEDEHIIVLNKSAGLTVHPAPGNKDGTLVNGLLHHCPDLPGISGKLRPGIVHRLDK 165

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADK 114
            TSG +++  S EA   L  Q ++    + Y A+V G    +   +   +          
Sbjct: 166 DTSGCIVVAKSQEALVKLQVQIQKRVASREYFAVVHGVPDGDSGTIIGAVGRHPVDRKKY 225

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
               D+  + A TH+  +                Y L+  +  TGR HQ+R H AH+ HP
Sbjct: 226 AVVSDESGRYARTHWTLIERF-----------GDYSLLRFKLDTGRTHQIRVHCAHINHP 274

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           ++GD  +   R+         L    LHA QL L HP TGE +   A L     + L   
Sbjct: 275 VVGDPTYSRCRKLP-----LDLPGQALHAVQLGLDHPITGERMVFEAPLPPVMEKLLLVL 329

Query: 235 GWRG 238
             R 
Sbjct: 330 RRRS 333


>UniRef50_D2BIX0 Pseudouridine synthase n=5 Tax=Dehalococcoides RepID=D2BIX0_DEHSV
          Length = 302

 Score =  304 bits (781), Expect = 1e-81,   Method: Composition-based stats.
 Identities = 66/241 (27%), Positives = 107/241 (44%), Gaps = 28/241 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQ------IGQHVFTAHRLDR 55
           LEI++QD+ L+ +NKP G  VH +    D  ++      +               HRLD+
Sbjct: 80  LEIIFQDKDLLLINKPPGLTVHPAPGHPDHTLINGVLALEPKMEDFDDPLRPGIVHRLDK 139

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADK 114
            TSG+LL+  + E    L+ QF++  ++K Y  +V+G L   E  ++ PL  +       
Sbjct: 140 DTSGLLLVAKNRETLANLSAQFKERTVRKYYLTLVKGELHPAEGFIEAPLGRDPQNRQKI 199

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
                   + A T Y+ L  +             Y L+E++ +TGR HQ+R H A + HP
Sbjct: 200 AVV--SNGRHARTGYKVLRYI-----------QGYSLLEVKLETGRTHQIRVHFAAIGHP 246

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           + GD+ +G             L+R  LHA +LS T P  G+ +   + L     + L   
Sbjct: 247 VAGDAIYGQKETW--------LKRQFLHAHRLSFTLPSNGQTVEFTSPLPPDLEETLKIL 298

Query: 235 G 235
            
Sbjct: 299 E 299


>UniRef50_A0L9J0 Pseudouridine synthase n=1 Tax=Magnetococcus sp. MC-1
           RepID=A0L9J0_MAGSM
          Length = 332

 Score =  304 bits (781), Expect = 1e-81,   Method: Composition-based stats.
 Identities = 65/253 (25%), Positives = 104/253 (41%), Gaps = 32/253 (12%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ-------------HVF 48
           LEIL++DE L+ +NKP+G +VH         +V                           
Sbjct: 87  LEILFEDEHLIVLNKPAGMVVHPGAGVNHGTLVNALLYHCGTPDNPHGGLSGIGGVIRPG 146

Query: 49  TAHRLDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEE 107
             HRLD+ TSG+++      A   L++QFEQ  I +RY A+ RG     +  ++  +   
Sbjct: 147 IVHRLDKETSGIMVAAKQDHAHIHLSRQFEQRTIGRRYLALTRGIPQPAQGRIEGAIGRH 206

Query: 108 LDKIADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRH 167
                      ++G + A T Y+ L            P  ++ L+    ++GR HQ+R H
Sbjct: 207 PIHRTKMAVV-EQGGRAAATRYKVLE-----------PLGQFALIRCRLESGRTHQIRVH 254

Query: 168 LAHLRHPIIGDSKHGDLRQNRSGAEHFG------LQRLMLHASQLSLTHPFTGEPLTIHA 221
           + H+ HP++GD  +G   +  S             QR  LHA  L+  HP TGE ++   
Sbjct: 255 MTHIGHPLVGDPLYGAQHKAPSHWPPLHRQRFDQFQRQALHAHTLTFIHPHTGEEMSFKR 314

Query: 222 GLDDTWMQALSQF 234
                + Q     
Sbjct: 315 PPPADFRQLYETL 327


>UniRef50_Q2LWV4 Pseudouridine synthase n=1 Tax=Syntrophus aciditrophicus SB
           RepID=Q2LWV4_SYNAS
          Length = 333

 Score =  304 bits (780), Expect = 2e-81,   Method: Composition-based stats.
 Identities = 68/247 (27%), Positives = 115/247 (46%), Gaps = 25/247 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ------HVFTAHRLDR 55
           L ILY+D  L+ ++KP+G +VH +       +V       +              HRLD+
Sbjct: 85  LSILYEDHDLLVLDKPAGLVVHPAAGHVSGTLVNALLFHCRDLAGIGGVMRPGIVHRLDK 144

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADK 114
            TSG+L++  +  A + LA QF++HQ+ K Y A+V G   E+   +D P+     +   K
Sbjct: 145 DTSGLLVVAKTDAAHQGLALQFKKHQVGKTYQALVYGDPREKTGQIDLPVGRHPVER-KK 203

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
            + + +  + A T +R      +             L+ ++  TGR HQ+R HLA + HP
Sbjct: 204 MSTKSRRGKEAATRWRIAERFGV-----------ATLLNVDIVTGRTHQIRVHLAAIGHP 252

Query: 175 IIGDSKHGDLRQNRSGAEHF------GLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWM 228
           ++GD+ +G  ++  +  +         + R  LHA++LS THP T + L  HA L     
Sbjct: 253 VVGDAVYGSSKRATTLTDPAVKGRLKEMSRQALHAARLSFTHPVTHKILEFHAPLPADME 312

Query: 229 QALSQFG 235
              +   
Sbjct: 313 DLCAFLR 319


>UniRef50_Q87AR7 Ribosomal large subunit pseudouridine synthase D n=18
           Tax=Gammaproteobacteria RepID=RLUD_XYLFT
          Length = 331

 Score =  304 bits (780), Expect = 2e-81,   Method: Composition-based stats.
 Identities = 71/248 (28%), Positives = 107/248 (43%), Gaps = 22/248 (8%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG---QHVFTAHRLDRPTS 58
           L+ILY+DE +  +NKP+G +VH    + D  +V     RD            HRLD+ TS
Sbjct: 90  LDILYEDEHVFVINKPAGLVVHPGAGNPDGTLVNALLHRDPALAAVPRAGVVHRLDKDTS 149

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           GV+++  + +A   L +Q    Q+ ++Y A+V   L+    ++  +              
Sbjct: 150 GVMVVARTLQAQTALVEQLSSRQVHRQYLAVVVSALVSGGTVNAAIERHPRDRLRMEV-- 207

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
               + AVTHYR                  +  +E    TGR HQ+R H+AHLRHPI+GD
Sbjct: 208 SDTGKEAVTHYRLRERFRA-----------HTALECRLDTGRTHQIRVHMAHLRHPIVGD 256

Query: 179 SKHGD------LRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALS 232
             +G          +   A   G +R  LHA  L   HP    P+ I A + +   Q L+
Sbjct: 257 RLYGGSLKLPKGGTDALVAMLRGFKRQALHAEVLEFLHPVRALPVRIVAPVPEDLCQLLA 316

Query: 233 QFGWRGLL 240
                  L
Sbjct: 317 ALREDSAL 324


>UniRef50_A1AW00 Pseudouridine synthase n=2 Tax=sulfur-oxidizing symbionts
           RepID=A1AW00_RUTMC
          Length = 314

 Score =  304 bits (779), Expect = 3e-81,   Method: Composition-based stats.
 Identities = 61/243 (25%), Positives = 106/243 (43%), Gaps = 22/243 (9%)

Query: 1   MLEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRD---QIGQHVFTAHRLDRPT 57
           +++++Y+DE ++ VNKP   + H    +    +       D            HRLD+ T
Sbjct: 79  VIDVVYEDEAIIIVNKPVNLVTHPGVSNWTGTLANALLHYDSSLANLDRAGIVHRLDKNT 138

Query: 58  SGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAR 117
           SG++++  S  A + L +Q + H I + Y AIV G ++    +D P+  +      +   
Sbjct: 139 SGLMVVARSEYAQKYLTRQLQTHSISREYSAIVYGHMISGGTVDKPIGRDPKDRIRQTVT 198

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
           E    + A+THYR +                +  V++  +TGR HQ+R HL+ + HP+I 
Sbjct: 199 ES--GKDALTHYRVIERF-----------AHHTHVKVMLETGRTHQIRVHLSFIGHPLIA 245

Query: 178 DSKHGDLRQNRSGAEHFG------LQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
           D  +G   +    A+           R  LHA +L+L HP + E ++    L       L
Sbjct: 246 DPMYGGKIRFPKKADKQLKNSLKNFNRQTLHAKKLTLIHPTSTELMSWKVPLPQDMQDLL 305

Query: 232 SQF 234
              
Sbjct: 306 QVL 308


>UniRef50_D0RPR1 Pseudouridine synthase n=1 Tax=alpha proteobacterium HIMB114
           RepID=D0RPR1_9RICK
          Length = 325

 Score =  303 bits (778), Expect = 3e-81,   Method: Composition-based stats.
 Identities = 60/248 (24%), Positives = 110/248 (44%), Gaps = 21/248 (8%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG-------QHVFTAHRLD 54
           L I+++D+ ++ ++KP G +VH    + ++ +V       +               HR+D
Sbjct: 81  LNIIFEDQDIIIIDKPIGMVVHPGAGNYEDTMVNGLLYHCKNNLSGMNGEDRPGIVHRID 140

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIAD 113
           + TSG+L++  + +A   +A+QFE+H I++ Y   V G L      ++  +         
Sbjct: 141 KDTSGLLVVAKNDQAHAFIAKQFEEHSIKRSYLVFVYGILRPLHGKIETLIGRNKTNRQK 200

Query: 114 KFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
             A   +  + A+T+Y  L   +              LV+   +TGR HQ+R H++H  +
Sbjct: 201 MSADVIR-GKDAITNYETLEVFKGNKIP------DISLVKCILETGRTHQIRVHMSHKGN 253

Query: 174 PIIGDSKHGDLRQNRSGAEHF------GLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTW 227
           PI+GD  +G   +   G +         L+R  LHA  L   HP T E +   + L D  
Sbjct: 254 PILGDQTYGKKIKKIRGIDQEFEEILKSLKRQALHAHTLGFIHPTTNEEVFFASELPDDL 313

Query: 228 MQALSQFG 235
            +  ++  
Sbjct: 314 NKLKNRLE 321


>UniRef50_B8J173 Pseudouridine synthase, RluA family n=2 Tax=Desulfovibrio
           RepID=B8J173_DESDA
          Length = 525

 Score =  303 bits (778), Expect = 3e-81,   Method: Composition-based stats.
 Identities = 74/265 (27%), Positives = 108/265 (40%), Gaps = 29/265 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQ-----IGQHVFTAHRLDRP 56
           LE+L+QD+ LV  NKP+G  VH      ++ +V     R        GQ     HRLD+ 
Sbjct: 80  LELLWQDDHLVVCNKPAGLTVHPCPSCPEQTLVQRLLGRFPQLSRLEGQRPGIVHRLDKD 139

Query: 57  TSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFA 116
           TSG+L++ L+      LA  F + Q+ K Y A+V G    E     PL            
Sbjct: 140 TSGLLVVALTEADCLALAAAFAERQVHKEYLALVSGLPPLEGQCREPLGRHPTAKIKMAV 199

Query: 117 RE-DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
              D+G + A T +R L   +              L+ +   TGR HQ+R H+ HL +P+
Sbjct: 200 VPEDQGGRNAFTEWRRLWNTD---------DGSVSLLAVRIHTGRTHQIRVHMTHLGYPL 250

Query: 176 IGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFG 235
           +GD  +         A      R MLHA +L  THP +GE +                  
Sbjct: 251 LGDRLY------APKAVQNMAPRQMLHAWRLGFTHPASGEDMRFTCPPPHDM-------- 296

Query: 236 WRGLLPENERVEFSAPSGQDGEISS 260
               L   +R++    +G  G   S
Sbjct: 297 PDAALAAMQRMQRLVITGNPGSGKS 321


>UniRef50_D0KVM5 Pseudouridine synthase n=11 Tax=Proteobacteria RepID=D0KVM5_HALNC
          Length = 340

 Score =  303 bits (778), Expect = 3e-81,   Method: Composition-based stats.
 Identities = 63/242 (26%), Positives = 109/242 (45%), Gaps = 22/242 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG---QHVFTAHRLDRPTS 58
           L+I+Y+D+ ++ +NK    +VH +  + D  +V      D            HRLD+ TS
Sbjct: 81  LDIIYEDDAIIVLNKSPDIVVHPAAGNPDGTLVNALLFHDPSLVSVPRAGVVHRLDKQTS 140

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           GV+++  +  A ++L +     +I++ Y  +V G ++    +D P+         +    
Sbjct: 141 GVMVVAKTLAAHKILVENLAARKIRREYDTVVMGHVVAGGTVDAPIGRHPRDRQRQAVT- 199

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
               + AVTHYR L                   + ++ +TGR HQ+R H+AH+RHP+IGD
Sbjct: 200 -ATGKRAVTHYRVLQHY-----------GEQTWLRVQLETGRTHQIRVHMAHIRHPVIGD 247

Query: 179 SKHGDLRQNRSGAEHFGLQ------RLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALS 232
             +G   +    A    +       R  LHA  L+L HP TG  +   A + D   + ++
Sbjct: 248 PVYGGRPRIPPRASTALIDVLRHFERQALHARYLTLAHPVTGTQMRFEAPMPDDMRELIA 307

Query: 233 QF 234
             
Sbjct: 308 LL 309


>UniRef50_O50310 Uncharacterized RNA pseudouridine synthase Cpar_0723 n=13
           Tax=Chlorobiaceae RepID=Y723_CHLP8
          Length = 327

 Score =  303 bits (777), Expect = 5e-81,   Method: Composition-based stats.
 Identities = 64/254 (25%), Positives = 104/254 (40%), Gaps = 31/254 (12%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVR--------DQIGQHVFTAHRL 53
           + ILY+D+ L+ ++K +G +VH ++ +    +               D+        HRL
Sbjct: 77  ITILYEDDDLMVIDKEAGMVVHPAFGNWTGTLANAILHHLGKDADELDKTEMRPGIVHRL 136

Query: 54  DRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIA 112
           D+ TSG++++  +  A   LA+QF   Q++K Y AIV G    E   +   +        
Sbjct: 137 DKDTSGLIIIAKNPTALHKLARQFANRQVEKVYKAIVWGVPKAESGTIKTNIGRSHKNRK 196

Query: 113 DKFAREDKG--PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAH 170
                  +G   + A+T Y+ +                + L+++   TGR HQ+R HL H
Sbjct: 197 VMANFPYEGAEGKHAITDYQVVE-----------DLGYFSLMDVTLHTGRTHQIRVHLQH 245

Query: 171 LRHPIIGDSKHGDLRQNRSGAEH---------FGLQRLMLHASQLSLTHPFTGEPLTIHA 221
           L H I+GD  +G                      + R  LHA  L    P TGEPL+  A
Sbjct: 246 LGHSILGDETYGGATPRTLPFSKSEPFTRNLLELMSRQALHAQTLRFRQPTTGEPLSFSA 305

Query: 222 GLDDTWMQALSQFG 235
            L +     L +  
Sbjct: 306 PLPEDMELVLEKIR 319


>UniRef50_B1I3F8 Pseudouridine synthase n=2 Tax=Bacteria RepID=B1I3F8_DESAP
          Length = 309

 Score =  302 bits (775), Expect = 7e-81,   Method: Composition-based stats.
 Identities = 71/240 (29%), Positives = 105/240 (43%), Gaps = 25/240 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ------HVFTAHRLDR 55
           LE+ ++D  ++ VNKP G +VH +       +V       +              HRLDR
Sbjct: 81  LEVCFEDPDVLVVNKPRGLVVHPAVGHYSGTLVNALLHHCRDLSGINGILRPGIVHRLDR 140

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADK 114
            TSG+L++  +  A   LA Q +   + +RY A+V G    E   +D P+          
Sbjct: 141 DTSGLLMVAKNDAAHLALAGQLKDRAVLRRYTALVHGRPRRETGTVDAPIGRHPRDRQRM 200

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
                +  + A THYR +   +           ++ L+EL   TGR HQ+R H+AH+ HP
Sbjct: 201 AVTP-RSGRAARTHYRVVRRFD-----------KFSLLELTLDTGRTHQIRVHMAHVGHP 248

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           ++GD K+G  R         GL+   LHA  L   HP TGE L   A L       L + 
Sbjct: 249 LVGDLKYGHARPE------LGLEGQFLHAGTLGFRHPRTGEVLVFEAPLPSELAAVLERL 302


>UniRef50_A6DUC9 Pseudouridine synthase n=1 Tax=Lentisphaera araneosa HTCC2155
           RepID=A6DUC9_9BACT
          Length = 323

 Score =  302 bits (774), Expect = 9e-81,   Method: Composition-based stats.
 Identities = 67/246 (27%), Positives = 112/246 (45%), Gaps = 25/246 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQI--------GQHVFTAHRL 53
           L+I+Y+D+ ++ VNKP+G +VH    +    +V     RD                 HRL
Sbjct: 90  LDIIYEDDDILVVNKPAGMVVHPGAGNYTGTLVNALLGRDLDTFSAMDDGSSRPGIVHRL 149

Query: 54  DRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIA 112
           D+ TSGV+++  S++    L++ F +  ++K Y A+ RG +      +   +        
Sbjct: 150 DKETSGVIIVAKSAKNLDKLSRSFARRDVEKYYVALCRGTIRVGRDTITSHIGRSRSNRQ 209

Query: 113 DKFAREDKG-PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHL 171
                 D    + A++HY+ LA                 LV+L+  TGR HQ+R H++ +
Sbjct: 210 KMENTNDSNRGKEAISHYKVLA-----------DNNGATLVKLKIDTGRTHQIRVHMSGI 258

Query: 172 RHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
            HP++GD  +G  R +    E     R +LHA +  + HP T E +T  A L D +    
Sbjct: 259 NHPVVGDKLYGVRRLD----EKESPDRHILHAWRTRIIHPGTQEIMTFTAPLHDDFKSVC 314

Query: 232 SQFGWR 237
            +FG  
Sbjct: 315 DKFGIE 320


>UniRef50_D1ANU4 Pseudouridine synthase n=14 Tax=Fusobacteriaceae RepID=D1ANU4_SEBTE
          Length = 305

 Score =  301 bits (772), Expect = 1e-80,   Method: Composition-based stats.
 Identities = 62/243 (25%), Positives = 113/243 (46%), Gaps = 27/243 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQI------GQHVFTAHRLDR 55
           ++ILY+D  +  ++K +G +VH S       +V       +              HRLD+
Sbjct: 77  IKILYEDSDIAVIDKEAGIVVHPSHGHESGTLVNAVMYHIKDLSGINGEIRPGIVHRLDK 136

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADK 114
            TSG+L++  +  A   L++ F    I+K Y AI++G +  E   L+  +  +       
Sbjct: 137 DTSGLLIIAKNDTAHLRLSEMFGSSGIRKTYIAILKGKINKESGKLETLIGRDPKDRKKM 196

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
              +    + A+T+++ L   E           ++ LV++  +TGR HQ+R H+ +L +P
Sbjct: 197 AVVKT-NGKTAITYFQVLDKNE-----------KFSLVKVNIQTGRTHQIRVHMKYLGYP 244

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           ++GDS +G         ++    R MLHA +L   HP T + + I + L   + +AL + 
Sbjct: 245 VLGDSVYG--------RDNKIAGRQMLHAYKLEFLHPVTQKAMKIISELPQDFEKALKET 296

Query: 235 GWR 237
           G  
Sbjct: 297 GLE 299


>UniRef50_Q0BWH2 Pseudouridine synthase n=3 Tax=Alphaproteobacteria
           RepID=Q0BWH2_HYPNA
          Length = 341

 Score =  301 bits (772), Expect = 2e-80,   Method: Composition-based stats.
 Identities = 72/258 (27%), Positives = 107/258 (41%), Gaps = 26/258 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG-------QHVFTAHRLD 54
           LEIL++D  LV +NK +G  VH +   +   +V       Q         +     HRLD
Sbjct: 81  LEILFEDAHLVILNKAAGMAVHPAPGSQTGTLVNALLHHCQGQLSGIGGVERPGIVHRLD 140

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIAD 113
           + TSGV++   +  A   LA  FE+H I + Y A+ RG        ++  +         
Sbjct: 141 KLTSGVMVAAKTESAHTGLAALFERHDIDRVYRAVTRGAPRPLSGTIEAAIARSESDRKK 200

Query: 114 KFAR---EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAH 170
                  +    + AVTHY+ + T        R P     L+E   +TGR HQ+R H+AH
Sbjct: 201 MSVHRNPDSPAARHAVTHYKAVETFGYKDRATRLPA--AALLECRLETGRTHQIRVHMAH 258

Query: 171 LRHPIIGDSKHGD-------------LRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPL 217
              P+IGD  +G               R +++ A      R  LHA+ L   HP TGE L
Sbjct: 259 SGAPLIGDPVYGRQAGIMAWKAPGSEARYDKALAAARAFSRQALHAAVLGFVHPITGETL 318

Query: 218 TIHAGLDDTWMQALSQFG 235
              A L +     ++   
Sbjct: 319 RYEAPLPEDMTGLIAALR 336


>UniRef50_D1VS73 Pseudouridine synthase n=1 Tax=Peptoniphilus lacrimalis 315-B
           RepID=D1VS73_9FIRM
          Length = 295

 Score =  301 bits (771), Expect = 2e-80,   Method: Composition-based stats.
 Identities = 56/239 (23%), Positives = 104/239 (43%), Gaps = 25/239 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVR------DQIGQHVFTAHRLDR 55
             ++Y+DE++  ++KP   +VH    +    +V     +      D         HRLD+
Sbjct: 75  FNVIYEDEYIAVISKPQDLVVHIGAGNSSGTLVNGLLYKFKNQLSDLDPLRPGIVHRLDK 134

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKF 115
            TSG++++  +++A   L  QF+  QI+K Y AIV G   E  ++  P+    +      
Sbjct: 135 NTSGLMIIAKNNQAHINLVDQFKNSQIKKYYLAIVHGKTPESGIIAEPIGRNPNDRKKMA 194

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
               K  + A+T Y+ L                Y L+ +   TGR HQ+R H+A++ +P+
Sbjct: 195 VVY-KNSKQAITKYKKLKEF-----------QEYSLLNINLLTGRTHQIRVHMAYIGYPV 242

Query: 176 IGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           +GD  +G             + + MLH+ +L   HP T + +         + + + + 
Sbjct: 243 LGDIIYGRK-------NSLKIDKQMLHSYKLIFNHPITNQKMEFTDEFPIRFKKFIDKI 294


>UniRef50_A6C0W7 Pseudouridine synthase n=1 Tax=Planctomyces maris DSM 8797
           RepID=A6C0W7_9PLAN
          Length = 342

 Score =  300 bits (770), Expect = 3e-80,   Method: Composition-based stats.
 Identities = 65/256 (25%), Positives = 111/256 (43%), Gaps = 32/256 (12%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV-VMQTVRDQIGQ-----HVFTAHRLDR 55
           ++I+Y+D+W+  +NKPS  +VH    +    +   +Q   DQ+            HRLDR
Sbjct: 93  IDIVYEDDWIAIINKPSDMIVHPGKGNYAGTLAGALQYHFDQLSDVAGQYRPGIVHRLDR 152

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADK 114
            TSG++++   ++    L+ QFE+  +QK Y AIV G +  +   +D  +          
Sbjct: 153 NTSGIMVVAKDNQVHAKLSAQFEKRDVQKEYRAIVWGRMEFDTDYIDTFMCVHPRAREKM 212

Query: 115 FAREDKG-PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
              ++ G  + A T+Y  +                +  V L+P+TGR HQLR H+ H+ H
Sbjct: 213 IVCDEGGNARNAFTYYEVIERY-----------QAFTYVRLKPRTGRTHQLRVHMQHIGH 261

Query: 174 PIIGDSKHGDLRQNR-------------SGAEHFGLQRLMLHASQLSLTHPFTGEPLTIH 220
            I+ D  +G  +  +                    ++R  LHA  L   HP +G+P+   
Sbjct: 262 SIVADRVYGGHKSLKMKSLGIQAEADAAELESDVLIERQALHAYCLEFFHPQSGKPMKFE 321

Query: 221 AGLDDTWMQALSQFGW 236
           A L +     L+    
Sbjct: 322 APLPEDMQNTLAALDQ 337


>UniRef50_C9LM35 Pseudouridine synthase n=1 Tax=Dialister invisus DSM 15470
           RepID=C9LM35_9FIRM
          Length = 308

 Score =  300 bits (770), Expect = 3e-80,   Method: Composition-based stats.
 Identities = 65/247 (26%), Positives = 112/247 (45%), Gaps = 26/247 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQ-------IGQHVFTAHRLD 54
           L+ILY+D  ++ +NK  G +VH    + +  +V                 +     HRLD
Sbjct: 80  LDILYEDNDMIVINKRRGVVVHPGAGNTEGTLVNALLFHCGEQLRSVGDPERPGIVHRLD 139

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIAD 113
           + TSGV++   S  A  +L ++   H+ Q+ Y A+V G +  +  V+  PL         
Sbjct: 140 KDTSGVMVAAKSERAYGILQKEIASHKAQRCYIALVHGQMEGDTGVIRLPLGRSTKDRMK 199

Query: 114 KFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
                 +  +PAVTH+  +  +             Y  +E + +TGR HQ+R H+AH+RH
Sbjct: 200 WDV-LHETGRPAVTHFHVIEYLP-----------HYSWIECKLETGRTHQIRVHMAHIRH 247

Query: 174 PIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
            ++ D  +G  +      +HF ++   LH+  L L HP TGE +   A + +  +  L+ 
Sbjct: 248 AVVNDPLYGWKK------DHFPIKGQALHSHTLELCHPITGEVMHFEAPVPEDMINCLNL 301

Query: 234 FGWRGLL 240
                +L
Sbjct: 302 ARKESML 308


>UniRef50_D1U4S9 Pseudouridine synthase, RluA family n=1 Tax=Desulfovibrio
           aespoeensis Aspo-2 RepID=D1U4S9_9DELT
          Length = 596

 Score =  300 bits (770), Expect = 3e-80,   Method: Composition-based stats.
 Identities = 69/273 (25%), Positives = 107/273 (39%), Gaps = 32/273 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQI---------GQHVFTAHR 52
           LE++++D  +  ++K +G   H +  +    +V     R             Q     HR
Sbjct: 99  LEVVFEDAHVAVIDKRAGLTTHPAPGEPGPTLVNHLLHRWPDVASDISGMDRQRPGIVHR 158

Query: 53  LDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKI 111
           LD+ TSG++++ L+      LA  F   +++K Y A+V G        +D P+     + 
Sbjct: 159 LDKDTSGLMVVALTEGDRLRLAADFAGRRVRKVYLAVVLGRPAQPAGTIDAPMGRHPSQK 218

Query: 112 ADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHL 171
                   +G + AV+ YR L T          P     LV +   TGR HQ+R H+AH+
Sbjct: 219 TRMAVV-ARGGREAVSDYRVLWT---------GPRGLASLVAVRIHTGRTHQIRVHMAHI 268

Query: 172 RHPIIGDSKHGDLRQ----NRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTW 227
            HP++GDS +G         R         R MLHA  LS  HP T E +T+       +
Sbjct: 269 GHPLLGDSAYGPRENVEWSRRPDRLAGLAPRQMLHAFHLSFRHPATCERVTLWRRPPADF 328

Query: 228 MQALSQFGWRGLLPENERVEFSAPSGQDGEISS 260
              L+                    G  G   S
Sbjct: 329 CTLLAAL--------PRECLRVGIVGMPGSGKS 353


>UniRef50_A5GW76 Pseudouridine synthase n=1 Tax=Synechococcus sp. RCC307
           RepID=A5GW76_SYNR3
          Length = 316

 Score =  300 bits (769), Expect = 3e-80,   Method: Composition-based stats.
 Identities = 63/245 (25%), Positives = 100/245 (40%), Gaps = 23/245 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ------HVFTAHRLDR 55
           L++L++DE L+ +NKP+G  VH +  ++D  +V                      HRLD+
Sbjct: 88  LDVLFEDEHLIVINKPAGLTVHPAPGNKDGTLVNGLLHHCPDLPGISGKLRPGIVHRLDK 147

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADK 114
            T+G +++  S +A   L  Q ++    + Y A+V G    E   +   +          
Sbjct: 148 DTTGCIVIAKSQQALVKLQVQIQKRVASREYLAVVHGVPAGESGTIVGAIGRHPVDRKKY 207

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
                   + A TH+     +             Y L+  +  TGR HQ+R H AH  HP
Sbjct: 208 AVVSSDNGRYACTHWSLQERL-----------GDYSLLRFKLDTGRTHQIRVHCAHRNHP 256

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           ++GD  +   R+         L    LHA QL L HP TGE +   A L +   + L+  
Sbjct: 257 VVGDPTYSRCRKLP-----IELPGQALHAVQLGLDHPITGERMVFEAPLPEVLEKLLAVL 311

Query: 235 GWRGL 239
             R  
Sbjct: 312 RKRAA 316


>UniRef50_P65834 Ribosomal large subunit pseudouridine synthase D n=321
           Tax=Gammaproteobacteria RepID=RLUD_ECOL6
          Length = 326

 Score =  300 bits (769), Expect = 3e-80,   Method: Composition-based stats.
 Identities = 62/245 (25%), Positives = 108/245 (44%), Gaps = 22/245 (8%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQI---GQHVFTAHRLDRPTS 58
           L+I+Y+DE ++ +NKP   +VH    + D  V+                   HRLD+ T+
Sbjct: 84  LDIVYEDEDIIVINKPRDLVVHPGAGNPDGTVLNALLHYYPPIADVPRAGIVHRLDKDTT 143

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           G++++  +  A   L +  ++ +I + Y A+  G +     +D P+     K        
Sbjct: 144 GLMVVAKTVPAQTRLVESLQRREITREYEAVAIGHMTAGGTVDEPISRHPTKRTHMAV-- 201

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
               +PAVTHYR +    +           +  + L  +TGR HQ+R H+AH+ HP++GD
Sbjct: 202 HPMGKPAVTHYRIMEHFRV-----------HTRLRLRLETGRTHQIRVHMAHITHPLVGD 250

Query: 179 SKHGDLRQNRSGAEHFGL------QRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALS 232
             +G   +   GA    +       R  LHA+ L L HP +G  +  HA +    ++ + 
Sbjct: 251 PVYGGRPRPPKGASEAFISTLRKFDRQALHATMLRLYHPISGIEMEWHAPIPQDMVELIE 310

Query: 233 QFGWR 237
                
Sbjct: 311 VMRAD 315


>UniRef50_Q13E92 Pseudouridine synthase n=28 Tax=Alphaproteobacteria
           RepID=Q13E92_RHOPS
          Length = 426

 Score =  300 bits (769), Expect = 4e-80,   Method: Composition-based stats.
 Identities = 67/252 (26%), Positives = 113/252 (44%), Gaps = 26/252 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG-------QHVFTAHRLD 54
           LEI+++D+ ++ ++KP G +VH +       +V                 +     HRLD
Sbjct: 178 LEIVHEDDDIIVIDKPRGLVVHPAAGHETGTLVNALIAHCGESLSGIGGVRRPGIVHRLD 237

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQH----QIQKRYHAIVRGWLME-EAVLDYPLVEELD 109
           + T+G+++   +  A + L+ QF  H    ++++ Y+A V G        +D P+     
Sbjct: 238 KDTTGLMVAAKNDRAHQSLSAQFADHGRTGELRRGYYAFVWGAPNRIRGTIDAPIDRHPH 297

Query: 110 KIADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLA 169
                  R+  G + A+TH+  L T      TGR       L+  + +TGR HQ+R HLA
Sbjct: 298 AREKMAVRD--GGREAITHWEVLETF-----TGRSGGEIVSLIACQLETGRTHQIRVHLA 350

Query: 170 HLRHPIIGDSKHGDLRQNRSGAEHF-------GLQRLMLHASQLSLTHPFTGEPLTIHAG 222
           H+ HP++GD  +G   + ++             L R  LHA  L L HP TGE +   +G
Sbjct: 351 HIGHPLLGDDVYGPHFKTKASQLRPDARAALTDLGRQALHAYLLVLEHPSTGEVVAWESG 410

Query: 223 LDDTWMQALSQF 234
           L     +  +  
Sbjct: 411 LPADLKRLKAAL 422


>UniRef50_A8GQ59 Pseudouridine synthase n=15 Tax=Rickettsia RepID=A8GQ59_RICAH
          Length = 329

 Score =  299 bits (768), Expect = 5e-80,   Method: Composition-based stats.
 Identities = 62/245 (25%), Positives = 108/245 (44%), Gaps = 23/245 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRD------QIGQHVFTAHRLDR 55
           L+I+Y+D+ L+ +NK +G  VH      D+ +V                      HRLD+
Sbjct: 79  LDIIYEDDDLIVINKAAGMTVHPGAGHHDDTLVNALLYHTKNLSDIGSAARPGIVHRLDK 138

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADK 114
            T+G++++  +++A  LLA Q EQ Q+ ++Y A+V G +     V+   +     +    
Sbjct: 139 DTTGLMVVAKNNKAHMLLANQIEQRQVIRKYKALVWGVINPLAGVIKNNIGRSRVERQKM 198

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
                 G + AVTHY+ L                  +VE    TGR HQ+R  L+H++H 
Sbjct: 199 SI-LKYGGKEAVTHYKTLELFY---------GGTISMVECRLNTGRTHQIRVQLSHVKHS 248

Query: 175 IIGDSKHGDLRQN------RSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWM 228
           ++GD  +G+  +          A+    +R  LH+  LS THP + + +     L     
Sbjct: 249 VVGDQTYGNNDRKIAHSSPALKAKLIDFKRQALHSWYLSFTHPTSNKIMEFSCELPRDME 308

Query: 229 QALSQ 233
             ++ 
Sbjct: 309 AIIAT 313


>UniRef50_B8GZR6 Pseudouridine synthase n=2 Tax=Caulobacter vibrioides
           RepID=B8GZR6_CAUCN
          Length = 342

 Score =  298 bits (765), Expect = 1e-79,   Method: Composition-based stats.
 Identities = 66/240 (27%), Positives = 92/240 (38%), Gaps = 18/240 (7%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG-------QHVFTAHRLD 54
           L ILY+D  L+ V+K +G  VH +    +  +V                       HRLD
Sbjct: 103 LSILYEDAHLIVVDKAAGMAVHPAPGTYNGTLVNALLHHCGASLSGVGGVARPGIVHRLD 162

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIAD 113
           + TSGV++   S  A R L+  F  H I + Y A+ RG        +   +         
Sbjct: 163 KDTSGVMVAAKSDAAHRGLSTLFATHDIDRLYVALTRGAPNPPTGTIQTQIGRSPGDRKK 222

Query: 114 KFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
                  G + A+THYR  A                  V    +TGR HQ+R H+A    
Sbjct: 223 MAV-LRAGGREAITHYRVEAAFGPADRPL------AARVACRLETGRTHQIRVHMASKGS 275

Query: 174 PIIGDSKHGDLRQNRSGAEHF---GLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQA 230
           P +GD  +G  +   +  E     GL+R  LHA+ L   HP TGE L     L       
Sbjct: 276 PCLGDPVYGAAQPAAAVRERIEAAGLRRQALHAAVLGFVHPITGETLRFETPLPADMDAL 335


>UniRef50_D1BAB3 Pseudouridine synthase n=1 Tax=Thermanaerovibrio acidaminovorans
           DSM 6589 RepID=D1BAB3_THEAS
          Length = 320

 Score =  298 bits (765), Expect = 1e-79,   Method: Composition-based stats.
 Identities = 65/236 (27%), Positives = 105/236 (44%), Gaps = 24/236 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG------QHVFTAHRLDR 55
             ++YQD+ LV V+KP+G +VH +       +V     R          +     HRLD 
Sbjct: 96  FRVVYQDQDLVVVDKPAGLVVHPAPGHWRGTLVHGLLYRYPDLMELNGVKRPGIVHRLDA 155

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKF 115
            TSG++++  +  A   L + F+  ++ K Y A+  G L  E  +  P+  + D      
Sbjct: 156 TTSGLMVVARNGLAMEGLVRAFKDRRVGKVYLAMAAGTLRGEGSVSLPIGRDPDNRKRMA 215

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
                  + A+T YR +           +    Y LV  + KTGR HQ+R H+  L HP+
Sbjct: 216 CV--PWGREALTRYRVI-----------WSRGGYSLVACQIKTGRTHQIRVHMRSLGHPL 262

Query: 176 IGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
           +GD  +G         E F L R+ LH+ +L   HP TG P++    L    ++ +
Sbjct: 263 VGDRIYGG-----PCPEGFPLGRVFLHSWRLEFDHPRTGAPMSFICPLPPDLVRFI 313


>UniRef50_D0J9U5 Pseudouridine synthase n=2 Tax=Blattabacterium RepID=D0J9U5_BLASP
          Length = 344

 Score =  298 bits (764), Expect = 2e-79,   Method: Composition-based stats.
 Identities = 59/263 (22%), Positives = 109/263 (41%), Gaps = 29/263 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ---HVFTAHRLDRPTS 58
           L ILY+DE ++ +NK +G +VH  + +    ++       +       +   HR+D+ T+
Sbjct: 87  LNILYEDEDILVINKAAGMVVHPGFGNEKGTLIHGIKYHFKNNHQLYRLGLVHRIDKDTT 146

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADKF-- 115
           G+L++  +  A + L QQF    IQ++Y A+V G +  +E  +   +  + +        
Sbjct: 147 GLLVLAKNEYAQKYLFQQFISKTIQRKYLALVWGNIQKQEGTISGFIGRDPNNRKRMTLF 206

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
            R     + +VTHY+ L   +               V    +TG+ HQ+R H  +L HP+
Sbjct: 207 QRNFYRSRYSVTHYKVLERFKY-----------LTYVSCNLETGKTHQIRVHFKYLGHPL 255

Query: 176 IGDSKHGDLR-----------QNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLD 224
             DS +G  +            +        L+R  LHA  LS  HP           + 
Sbjct: 256 FNDSTYGGDKIFMKKYLSKKSIDFFKDSLNLLKRQALHAGSLSFIHPK-NRKCHFTCSIP 314

Query: 225 DTWMQALSQFGWRGLLPENERVE 247
           + + + L +   +  +  +   E
Sbjct: 315 EDFKKVLQKLRNQYFITRSPEEE 337


>UniRef50_C1F7V3 Pseudouridine synthase n=1 Tax=Acidobacterium capsulatum ATCC 51196
           RepID=C1F7V3_ACIC5
          Length = 355

 Score =  297 bits (762), Expect = 2e-79,   Method: Composition-based stats.
 Identities = 72/258 (27%), Positives = 121/258 (46%), Gaps = 31/258 (12%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRD-----EKVVVMQTVRD------QIGQHVFTA 50
           L+I+Y+D+ L+ VNKP+G +VH      D       +V     R                
Sbjct: 104 LDIIYEDKDLIVVNKPAGMMVHAGSGATDSARNRGTLVNALLGRQEKLSKTGGDLRPGIV 163

Query: 51  HRLDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELD 109
           HRLD+ TSG++++  +  A + LA+ F Q +I K Y A+V G + E+   ++  +  ++ 
Sbjct: 164 HRLDKETSGLIIVARNDAAHQRLAEMFSQREIHKTYLALVHGHIAEDRGTINAAIARDVI 223

Query: 110 KIADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLA 169
           +      R  +G + A++HYR    +E           ++ LV +  +TGR HQ+R HL+
Sbjct: 224 RRTRMTTRRTEGARTAISHYRVQRRIETRW-------GKFTLVSVRIETGRTHQIRVHLS 276

Query: 170 HLRHPIIGDSKHG------------DLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPL 217
            + HP++GD+ +G              R+     E   L R  LHA++L   HP + +PL
Sbjct: 277 SIGHPVVGDTHYGAPTTIVLPVANRARRKQLPAPEGLSLPRNFLHAAELKFPHPRSEKPL 336

Query: 218 TIHAGLDDTWMQALSQFG 235
            + A L    +  L Q  
Sbjct: 337 HLEAPLPAELVAFLEQLE 354


>UniRef50_Q2SS88 Pseudouridine synthase n=4 Tax=Mollicutes RepID=Q2SS88_MYCCT
          Length = 322

 Score =  297 bits (762), Expect = 2e-79,   Method: Composition-based stats.
 Identities = 58/244 (23%), Positives = 106/244 (43%), Gaps = 25/244 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRD------QIGQHVFTAHRLDR 55
           L I+YQD+ L+ +NK +   VH S  + +  +V      D               HR+D+
Sbjct: 95  LNIIYQDDDLLVINKQNNITVHPSLNNTNNTIVNALLASDVELSSINGELRPGIVHRIDK 154

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADK 114
            T+G+L++  + +  +LL++ F+ HQI K Y AIV G +   + ++D P+          
Sbjct: 155 QTTGLLIVAKNDKTHKLLSEMFKNHQIYKEYLAIVTGVIKPNKGLIDAPIGRSQTDRKKM 214

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
                K  + A+T +  +                  L++ + +TGR HQ+R H  ++ HP
Sbjct: 215 SVT-AKNSKHAITTFEVVERFLKN-----------TLIKCQIQTGRTHQIRVHFNYINHP 262

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           ++ D  +G   Q  +           LHA +L  THP T + + + + L   +   + + 
Sbjct: 263 VLNDPIYGKKHQEFTDF------GQYLHAYKLKFTHPITKKEIELISPLPKEFDDKIKEL 316

Query: 235 GWRG 238
               
Sbjct: 317 RGEN 320


>UniRef50_Q1ILA4 Pseudouridine synthase n=1 Tax=Candidatus Koribacter versatilis
           Ellin345 RepID=Q1ILA4_ACIBL
          Length = 333

 Score =  297 bits (761), Expect = 3e-79,   Method: Composition-based stats.
 Identities = 67/253 (26%), Positives = 118/253 (46%), Gaps = 27/253 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRD-----EKVVVMQTVRD------QIGQHVFTA 50
           L+++Y+D+ L  +NKP+G +VH      +       +V     R                
Sbjct: 82  LDVVYEDDDLAVINKPAGMMVHVGAGATEEERNRGTLVNALLYRFRALSEVGGDMRPGIV 141

Query: 51  HRLDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELD 109
           HRLD+ TSG++++  +  A R LA+QF   ++ K+Y A+V GW  + +  ++ P+  ++ 
Sbjct: 142 HRLDKETSGLIVVAKNDVAHRKLAEQFSSRRVHKKYVALVHGWPKKLKGTINLPIARDMS 201

Query: 110 KIADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLA 169
           +      R   G + A++HY     +E P         ++ LVE++ +TGR HQ+R H+A
Sbjct: 202 RRTRMTTRGS-GGRDALSHYEVKEKIESPY-------GKFALVEVKIETGRTHQIRVHMA 253

Query: 170 HLRHPIIGDSKHGDLRQNRSGAEHFGLQ-------RLMLHASQLSLTHPFTGEPLTIHAG 222
            L HP++GD+ +G   + R      G+        R  LHA+++ L  P TG+ L     
Sbjct: 254 SLGHPVVGDTLYGAPGELRVTKALKGMPSKMASLERNFLHAAEIELQQPATGKALRFVTK 313

Query: 223 LDDTWMQALSQFG 235
           +            
Sbjct: 314 VPAALEDFAETLR 326


>UniRef50_C8WW59 Pseudouridine synthase n=2 Tax=Alicyclobacillus acidocaldarius
           RepID=C8WW59_ALIAD
          Length = 314

 Score =  296 bits (760), Expect = 4e-79,   Method: Composition-based stats.
 Identities = 63/240 (26%), Positives = 98/240 (40%), Gaps = 28/240 (11%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ------HVFTAHRLDRPT 57
           + Y+D+ ++ V+KP G +VH         +V     R                HR+D+ T
Sbjct: 91  VAYEDDDVIVVDKPRGVVVHPGAGHMRGTLVNGLLARGTPLCTLAGALRPGVVHRIDKDT 150

Query: 58  SGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADKFA 116
           SG+++   S  A R L + F  H +++ Y AI  G +   E  +D P+  +         
Sbjct: 151 SGLVVFAKSDRAYRALVEAFRAHDVEREYVAIAHGRMPHREGTIDMPIARDPADRQRMAV 210

Query: 117 REDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPII 176
           R  +G + AVTH+  L +             +Y  + L  +TGR HQ+R HLA + HPI 
Sbjct: 211 R--QGGKRAVTHFEVLESF-----------AKYSYLRLRLETGRTHQIRVHLAAIGHPIA 257

Query: 177 GDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGW 236
           GD  +G             +    LHA  L  THP  G  L   + +     + L     
Sbjct: 258 GDPVYGPRH-------TLPIDGQALHARTLGFTHP-DGRRLRFESAVPSDMARLLDGLRQ 309


>UniRef50_C6XNC0 Pseudouridine synthase n=1 Tax=Hirschia baltica ATCC 49814
           RepID=C6XNC0_HIRBI
          Length = 369

 Score =  296 bits (759), Expect = 5e-79,   Method: Composition-based stats.
 Identities = 62/262 (23%), Positives = 103/262 (39%), Gaps = 38/262 (14%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRD-------QIGQHVFTAHRLD 54
           L++L++DE L+ +NKP+G +VH +       +V                       HRLD
Sbjct: 98  LDVLFEDEHLIILNKPAGLVVHPAPGSTSGTLVNALLHHCAGQLPGIGGVARPGIVHRLD 157

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIAD 113
           + TSGV++   +  A   L+  F+ H +++ Y A+ RG        ++  +         
Sbjct: 158 KDTSGVMVAAKTEFAHTGLSSLFQAHFMERAYLAVTRGAPRPLLGKIETRIARSTTDRKK 217

Query: 114 KFARE------------------DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELE 155
                                  ++  + A+T+Y+ L       AT   P     L E  
Sbjct: 218 MAVVRESRLSASAEWHGESEEDYEQKGKHAITNYKVLEQFGRIDATSGLPA--ATLTECR 275

Query: 156 PKTGRKHQLRRHLAHLRHPIIGDSKHGDLRQNRSGAEHFG----------LQRLMLHASQ 205
            +TGR HQ+R H+AH+  P++GD  +G  R  ++                 +R  LHA+ 
Sbjct: 276 LETGRTHQIRVHMAHIGAPLLGDQTYGRYRGLKAHGSGPAFETATHACKEFKRQALHAAI 335

Query: 206 LSLTHPFTGEPLTIHAGLDDTW 227
           L   HP TGE L       +  
Sbjct: 336 LGFEHPVTGENLRFEVEPPEDM 357


>UniRef50_C5VRN0 Pseudouridine synthase n=1 Tax=Clostridium botulinum D str. 1873
           RepID=C5VRN0_CLOBO
          Length = 302

 Score =  295 bits (756), Expect = 1e-78,   Method: Composition-based stats.
 Identities = 62/240 (25%), Positives = 110/240 (45%), Gaps = 24/240 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQH---VFTAHRLDRPTS 58
           L+I+Y+D  ++ VNKP G +VH +    +  +                V   +RLD  TS
Sbjct: 83  LDIIYEDNDIIVVNKPKGIVVHPTKRHLNGTLSNGVLYYFNDKNENSIVRLVNRLDMDTS 142

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADKFAR 117
           G++L+  ++ +   L++  ++    K+Y AIV G   E+  V+D P+    +    +   
Sbjct: 143 GLVLIAKNAYSHMALSRDMQKDDFVKKYLAIVHGNFNEDSGVIDKPIYRVGEGTLKRII- 201

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
            D+  Q ++T ++ +   +              LVEL  +TGR HQ+R HL+ + HPI G
Sbjct: 202 -DERGQRSITLFKVIEQYK-----------NASLVELTLETGRTHQIRVHLSSIGHPIYG 249

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWR 237
           DS +G+            + R  LHA +L + HP  G+ L + + L +     + +    
Sbjct: 250 DSLYGEEEPQY-------IDRQALHAYKLQIPHPKDGKILKLESSLPEDMKNLIRKLSEE 302


>UniRef50_B9YI75 Pseudouridine synthase, RluA family n=1 Tax='Nostoc azollae' 0708
           RepID=B9YI75_ANAAZ
          Length = 329

 Score =  295 bits (756), Expect = 1e-78,   Method: Composition-based stats.
 Identities = 66/245 (26%), Positives = 109/245 (44%), Gaps = 24/245 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRD------QIGQHVFTAHRLDR 55
           L+ILY+DE L+ +NKP+G +VH +    D  +V                Q     HRLD+
Sbjct: 99  LDILYEDEQLLILNKPAGLVVHPAPGHLDGTLVNALLAHCANLPGIGGVQRPGIVHRLDK 158

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADK 114
            T+G + +  +  A + L  Q +    ++ Y  +V G    E  +++ P+          
Sbjct: 159 DTTGAIAIAKTDIAYQHLQAQLQAKTARREYLGVVYGVPKTESGIINLPISRHPQDRKKM 218

Query: 115 FARE-DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
                ++G + A+TH++    +           + Y L+  + +TGR HQ+R H A + H
Sbjct: 219 AIVPTEQGGRTAITHWQIRERL-----------SNYTLIHFQLETGRTHQIRVHSAKIGH 267

Query: 174 PIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           PI+GDS +G  R     +    L    LHA QL L HP +G+ + + A    T+   L  
Sbjct: 268 PIVGDSVYGAGR-----SVGVNLAGHALHAWQLKLQHPISGDWIQVTASPPQTFTTLLEV 322

Query: 234 FGWRG 238
              R 
Sbjct: 323 LRRRS 327


>UniRef50_B6BTN1 Pseudouridine synthase n=2 Tax=Betaproteobacteria
           RepID=B6BTN1_9PROT
          Length = 346

 Score =  295 bits (756), Expect = 1e-78,   Method: Composition-based stats.
 Identities = 55/244 (22%), Positives = 100/244 (40%), Gaps = 22/244 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHV---FTAHRLDRPTS 58
           L+I+Y+D+ ++ +NKP   +VH    + +  ++      ++  + +      HRLD+ T+
Sbjct: 84  LDIVYEDDDILVLNKPYNLVVHPGSGNANGTLLNGLLYYNKDLEKLPRGGIVHRLDKDTT 143

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           G++++  + E+   L  Q +   + + Y AIV G + +  V+  P+     +       +
Sbjct: 144 GLMVVAKNEESQNNLISQLQSKSVYREYRAIVWGQIWQNKVIQKPIGRHPRQRTKMAVTK 203

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
               + A T    L                +  V    KTGR HQ+R H+     PI+GD
Sbjct: 204 V-NGKDAETKLEILERFNY-----------HTYVRCLLKTGRTHQIRVHMLDNNSPIVGD 251

Query: 179 SKHGDLRQNRSGAEHFGL-------QRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
             +G  +   +      L        R  LHA  L L HP T + +     L +   + L
Sbjct: 252 KDYGLKKIIPTKNMEMDLLKSIKNFDRQALHAIALGLIHPKTNKEMKWTIDLPEDMKELL 311

Query: 232 SQFG 235
           S   
Sbjct: 312 SVIR 315


>UniRef50_Q03WF6 Pseudouridine synthase n=9 Tax=Firmicutes RepID=Q03WF6_LEUMM
          Length = 312

 Score =  294 bits (755), Expect = 1e-78,   Method: Composition-based stats.
 Identities = 65/228 (28%), Positives = 109/228 (47%), Gaps = 23/228 (10%)

Query: 13  AVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ-----HVFTAHRLDRPTSGVLLMGLSS 67
            VNKP G +VH +       +V        +            HR+DR TSG+L++  + 
Sbjct: 90  VVNKPQGMVVHPAAGHSSGTLVNALLHHSPLSTINGEFRPGIVHRIDRDTSGLLMVAKND 149

Query: 68  EAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADKFAREDKGPQPAV 126
           +A R L++Q + H+ Q+ Y+A+VRG   E+   ++ P+         +     +G + AV
Sbjct: 150 KAHRSLSEQLKSHKNQRVYYALVRGEFTEDSGTIEAPIGRHKIDRKKQAVI--EGGREAV 207

Query: 127 THYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHGDLRQ 186
           TH+R L                Y L+++  +TGR HQ+R H++++ HP++GD  +G    
Sbjct: 208 THFRVLKRYV-----------GYTLLKVSLETGRTHQIRVHMSYIGHPVVGDPVYG---- 252

Query: 187 NRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
                +   L   +LHA  L+L  P TG+ L+  + L D +  ALS  
Sbjct: 253 TAQKLDGTQLNGQLLHAKTLTLEQPTTGDELSFDSPLPDYFQFALSTL 300


>UniRef50_Q6MEC0 Pseudouridine synthase n=1 Tax=Candidatus Protochlamydia
           amoebophila UWE25 RepID=Q6MEC0_PARUW
          Length = 318

 Score =  294 bits (754), Expect = 2e-78,   Method: Composition-based stats.
 Identities = 58/248 (23%), Positives = 103/248 (41%), Gaps = 24/248 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ------HVFTAHRLDR 55
           L ILY+DE L+ +NKP+G +VH +  +     V       Q              HRLD+
Sbjct: 87  LSILYEDEHLLVINKPAGMVVHPAPGNWSGTFVNALLYYCQKLPLLPDTIRPGIVHRLDK 146

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKF 115
            TSG+L+   + E  + L + F   ++ K Y AI  G    +  +  P+           
Sbjct: 147 GTSGLLVAAKTLETQQKLIELFASRKVYKAYLAICIGRPA-DGEIQAPIGRHPIHRKQMA 205

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
                  +PA++  + L             + +   V++E  TGR HQ+R H+ +   PI
Sbjct: 206 VI--PTGKPAISFCKTL-----------GWSDKLSFVQIEIATGRTHQIRVHMKYRGSPI 252

Query: 176 IGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFG 235
           +GD  +G +  N    +++ +   +LHA+ L   HP + E L          ++ + +  
Sbjct: 253 LGDPLYGQISLN----QYYSVPHQLLHAAVLRFQHPISLENLEFCTPPPPEMVRLIKKID 308

Query: 236 WRGLLPEN 243
            +     +
Sbjct: 309 PKSPYIRD 316


>UniRef50_B0VJ94 Pseudouridine synthase n=1 Tax=Candidatus Cloacamonas
           acidaminovorans RepID=B0VJ94_9BACT
          Length = 351

 Score =  294 bits (754), Expect = 2e-78,   Method: Composition-based stats.
 Identities = 68/252 (26%), Positives = 113/252 (44%), Gaps = 32/252 (12%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG-------QHVFTAHRLD 54
           L+++Y+DE+L  +NK +G +VH  + + +  +V     R                 HRLD
Sbjct: 89  LDVVYEDEYLAIINKKAGMIVHPGFGNPEGTLVNAILYRFGENLSSGKEFNRPGIVHRLD 148

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIAD 113
           R TSG++++  +      L+  F + +I+K Y AI  G    E+  ++  L         
Sbjct: 149 RGTSGLIIIAKNDLTHAKLSDMFARREIKKTYFAITTGIPEPEKGEIETYLARSNKNP-- 206

Query: 114 KFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
           +        + A+THY+ + T              + LVE+ P TGR HQ+R H AH+R+
Sbjct: 207 RTICVTNEGRYALTHYKTIKTWHY-----------FALVEINPATGRMHQIRVHFAHIRY 255

Query: 174 PIIGDSKHGDLRQNRSGAEH-----------FGLQRLMLHASQLSLTHPFTGEPLTIHAG 222
           PI+GD  +   R  +S                 L+R  LH+ +L   HP TG P+++ A 
Sbjct: 256 PILGDLLYNSRRYVQSLVPQNMKKKVTELLVNHLRRQALHSWKLEFFHPITGYPISVSAP 315

Query: 223 LDDTWMQALSQF 234
           + D     L+  
Sbjct: 316 IPDDIQYTLNWL 327


>UniRef50_Q8DBG5 tRNA pseudouridine synthase C n=54 Tax=Gammaproteobacteria
           RepID=TRUC_VIBVU
          Length = 245

 Score =  294 bits (753), Expect = 3e-78,   Method: Composition-based stats.
 Identities = 143/240 (59%), Positives = 175/240 (72%)

Query: 1   MLEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGV 60
           MLEI+YQDE+ VAVNKP+G LVHRSWLD+ E   VMQT+RDQIGQHVF  HRLDRPTSGV
Sbjct: 1   MLEIVYQDEYFVAVNKPAGMLVHRSWLDKHETQFVMQTLRDQIGQHVFPLHRLDRPTSGV 60

Query: 61  LLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDK 120
           L+  LSSE    +   F   ++ K YHAIVRGW+ EE  LDY L  ELDKIADKFA ++K
Sbjct: 61  LVFALSSEVASQVMPMFAGQEMSKTYHAIVRGWIEEEGELDYALKVELDKIADKFASQEK 120

Query: 121 GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSK 180
             Q A+T Y+ LA VE+P +T ++PTTRYGL+EL+PKTGRKHQLRRH+AHLRHPI+GD+ 
Sbjct: 121 EAQDAITLYKPLAKVEVPYSTSKFPTTRYGLMELKPKTGRKHQLRRHMAHLRHPIVGDTT 180

Query: 181 HGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWRGLL 240
           HGD + N+   E F   RL+LHAS+L   HP+T + + I A +D  W Q   +F W   L
Sbjct: 181 HGDGKHNKLFREEFDAPRLLLHASELRFVHPYTQQEVVIRAEVDKVWQQLFERFEWPSTL 240


>UniRef50_B2RIT5 Pseudouridine synthase n=80 Tax=root RepID=B2RIT5_PORG3
          Length = 365

 Score =  294 bits (753), Expect = 3e-78,   Method: Composition-based stats.
 Identities = 61/254 (24%), Positives = 102/254 (40%), Gaps = 31/254 (12%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVR-------DQIGQHVFTAHRLD 54
           L+I+Y+D+ L+ +NKP+G +VH    +    +V             D +   +   HR+D
Sbjct: 110 LDIVYEDDVLLVINKPAGLVVHPGHGNYTGTLVNALAYYLREDPEYDPMDPSLGLVHRID 169

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIAD 113
           + TSG+L++   +EA   L +QF      + Y A+V G        +   +  +L     
Sbjct: 170 KDTSGLLVVAKRAEAKSDLCKQFYYKTTHRSYRALVWGRFDYPIGTITGNIGRDLKDRLQ 229

Query: 114 KFAREDKG--PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHL 171
                  G   +PAVTHY+ L  +                +E   +TGR HQ+R H+ H+
Sbjct: 230 MAVFPPDGDIGKPAVTHYQVLEELAY-----------VSWIECRLETGRTHQIRAHMKHI 278

Query: 172 RHPIIGDSKHGDLRQNRSGAEHF----------GLQRLMLHASQLSLTHPFTGEPLTIHA 221
            H +  D ++G  +  R                   R  LHA  L   HP TG  +   +
Sbjct: 279 GHTLFADERYGGDQILRGNNTANYRRFVQNCLAICPRQALHAKTLGFRHPVTGVEMQFDS 338

Query: 222 GLDDTWMQALSQFG 235
            +       L ++ 
Sbjct: 339 DIPADLTTLLERWR 352


>UniRef50_C7H7W3 Ribosomal large subunit pseudouridine synthase D n=2
           Tax=Faecalibacterium prausnitzii RepID=C7H7W3_9FIRM
          Length = 314

 Score =  293 bits (752), Expect = 3e-78,   Method: Composition-based stats.
 Identities = 65/246 (26%), Positives = 103/246 (41%), Gaps = 27/246 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG-------QHVFTAHRLD 54
           L+I+Y+D  L+ VNKP G +VH +  + D  +V       +               HR+D
Sbjct: 80  LDIIYEDAHLLVVNKPKGMVVHPAPGNPDGTLVNALLWHCKGSLSGIGGEIRPGIVHRVD 139

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIAD 113
           + TSG+L++         L+QQ   H +++ Y+ IV G    +E  ++  L         
Sbjct: 140 KDTSGLLVVAKDDATHIGLSQQMAVHSVERAYNTIVYGGFAQDEGFVESNLGRSKTDRKK 199

Query: 114 KFARE--DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHL 171
                  +   + A T Y+ L  +             + ++E   KTGR HQ+R H+A +
Sbjct: 200 MAVYPASEPHTKYAYTGYKVLERL-----------GEFTMLECRLKTGRTHQIRVHMASI 248

Query: 172 RHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
            HP+ GD  +G             L    LHA  L   HP TGE L   + L D + + L
Sbjct: 249 HHPVAGDPVYGPHNC------ITSLHGQCLHAKTLGFIHPITGEHLRFDSELPDYFTRFL 302

Query: 232 SQFGWR 237
           +    R
Sbjct: 303 TTLRQR 308


>UniRef50_A4WSV2 Pseudouridine synthase n=41 Tax=Alphaproteobacteria
           RepID=A4WSV2_RHOS5
          Length = 349

 Score =  293 bits (752), Expect = 4e-78,   Method: Composition-based stats.
 Identities = 66/257 (25%), Positives = 105/257 (40%), Gaps = 40/257 (15%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG-------QHVFTAHRLD 54
           L ++++D  L+ ++KP G +VH +       +V                 +     HR+D
Sbjct: 90  LSVVWEDADLIVIDKPVGMVVHPAPGQWTGTLVNALLHHCGASLSGIGGEKRPGIVHRID 149

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEA---------------- 98
           + TSG+L++  +  A + LA QFE H +++RY A+V G                      
Sbjct: 150 KDTSGLLVVAKTDRAHQGLAAQFEAHTVERRYLALVHGVPEPSDPRLRGIRGVSFEPGGV 209

Query: 99  -VLDYPLVEELDKIADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPK 157
             +   +         +    + G + AVT  R L     P A          LVE   +
Sbjct: 210 LRIATGIARHRTDRQRQAVTFE-GGRHAVTRARLLERFGTPPA--------AALVECRLE 260

Query: 158 TGRKHQLRRHLAHLRHPIIGDSKHGDLRQNRSGA-------EHFGLQRLMLHASQLSLTH 210
           TGR HQ+R H++H+ H +IGD  +G  R+  + A             R  LHA+ L   H
Sbjct: 261 TGRTHQIRVHMSHVGHGLIGDQTYGGRRKLSAKAVGAEAAQAAEAFPRQALHAATLGFCH 320

Query: 211 PFTGEPLTIHAGLDDTW 227
           P TGE L+  + L    
Sbjct: 321 PVTGEDLSFESPLPADM 337


>UniRef50_C0ZH07 Pseudouridine synthase n=1 Tax=Brevibacillus brevis NBRC 100599
           RepID=C0ZH07_BREBN
          Length = 306

 Score =  292 bits (750), Expect = 5e-78,   Method: Composition-based stats.
 Identities = 65/237 (27%), Positives = 108/237 (45%), Gaps = 25/237 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVV---MQTVRDQIGQHVFTAHRLDRPTS 58
           L I Y+DE L+ + KP+G +VH +       +         +    +     +RLD+ TS
Sbjct: 81  LSIRYEDEDLMVIAKPAGLVVHPTGNHPSGTLANGMIAYWKKRGENRKFRAVNRLDKDTS 140

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADKFAR 117
           G++++  +  A    ++  +   +Q+ Y AIV+G +  ++  ++ P+    +    +  R
Sbjct: 141 GLMIVAKNQWAHEQFSRMQQIRTLQRTYRAIVQGIVESDDGTINTPIGLAENSFITRQVR 200

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
            D   Q AVTHYR LA  E               VE++ +TGR HQ+R H++   HP+ G
Sbjct: 201 PD--GQTAVTHYRVLARGE-----------GMSFVEVKLETGRTHQIRVHMSSEGHPLAG 247

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           D  +G         E   + R  LHA  LS  HP +G  ++    L +   Q   QF
Sbjct: 248 DDLYGG--------EREHIGRQALHAWGLSFVHPRSGLAMSWEEPLPNDMEQLAQQF 296


>UniRef50_A3RGY8 Pseudouridine synthase n=1 Tax=uncultured bacterium
           RepID=A3RGY8_9BACT
          Length = 353

 Score =  292 bits (750), Expect = 5e-78,   Method: Composition-based stats.
 Identities = 57/241 (23%), Positives = 102/241 (42%), Gaps = 14/241 (5%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG---QHVFTAHRLDRPTS 58
           LE++++D+ ++ +NKP   +VH +       ++                   HRLD  TS
Sbjct: 110 LEVIFEDDAILVLNKPPKLVVHPAAGHWSGTLLNGLLAYAPTLIDVPRAGIVHRLDADTS 169

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           G++++  +  A   L +Q +   + + Y A+V G   +  V+D  +  +           
Sbjct: 170 GLMVVAKTLAAQTDLVRQLQSRTVTREYWALVLGVPSQRGVIDAAIGRDPRNPLRFKVST 229

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
            +  +PA THY  L + +               +    +TGR HQ+R HL H+ HP+IGD
Sbjct: 230 TEAAKPARTHYATLDSTKN-------AGADISWLACRLETGRTHQIRVHLEHVGHPLIGD 282

Query: 179 SKHGDL--RQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLT-IHAGLDDTWMQALSQFG 235
             +      +    A      R  LHA +L+L HP + + L   H+       Q + + G
Sbjct: 283 PVYRRRLPPRGEPAARWKEFDRQALHACRLALDHPVSRQRLNWFHSPA-ADLAQLMHELG 341

Query: 236 W 236
           +
Sbjct: 342 F 342


>UniRef50_Q4FN11 Pseudouridine synthase n=4 Tax=Bacteria RepID=Q4FN11_PELUB
          Length = 326

 Score =  292 bits (749), Expect = 8e-78,   Method: Composition-based stats.
 Identities = 61/251 (24%), Positives = 107/251 (42%), Gaps = 27/251 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ-------HVFTAHRLD 54
           L+I+Y+D+ L+ +NKP+G ++H    + DE +V      ++               HR+D
Sbjct: 82  LQIVYEDDDLLIINKPAGIIMHPGAGNYDETIVNALMHYNKDSLSTIGDELRPGIVHRID 141

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIAD 113
           + TSG++++  ++E    L+ QF +H I + Y  ++ G L      +D  +         
Sbjct: 142 KDTSGLIVIAKNNETHENLSHQFSEHTITRVYQLLIWGKLRPSSGKIDTFITRSSKNRQM 201

Query: 114 KFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
                 K  + A+T+Y+ +   E              LVE   +TGR HQ+R H+ H+ +
Sbjct: 202 MEVSNSK-GKRAITNYKTIEIFENDKTPT------LSLVECRLETGRTHQIRVHMTHMGN 254

Query: 174 PIIGDSKHGDLRQNRSGAEH---------FGLQRLMLHASQLSLTHPFTGEPLTIHAGLD 224
            I+GD   G  ++     ++         + L R  LHA  L   HP T E +   + L 
Sbjct: 255 SIMGD---GKYKKKYKKLKNIDTNLENLIYKLDRQFLHAQTLGFIHPRTNEEMVFTSILP 311

Query: 225 DTWMQALSQFG 235
                 L    
Sbjct: 312 QELENILVLLR 322


>UniRef50_Q8K9E9 Ribosomal large subunit pseudouridine synthase D n=4 Tax=Buchnera
           aphidicola RepID=RLUD_BUCAP
          Length = 315

 Score =  292 bits (749), Expect = 8e-78,   Method: Composition-based stats.
 Identities = 58/243 (23%), Positives = 111/243 (45%), Gaps = 23/243 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRD---QIGQHVFTAHRLDRPTS 58
           L  +Y+D  ++ +NKP G +VH    ++D  ++     R             HRLD+ TS
Sbjct: 84  LNTIYEDSNILIINKPPGLVVHPGAGNQDGTILNALLYRYTNISSIPRCGIIHRLDKDTS 143

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           G++++  +  +   L    ++ +I ++Y  I++G ++   +++YP++    K        
Sbjct: 144 GLMVIAKTIFSYNKLVTLLKKRKIIRKYQGIIKGNMISGGIVNYPIMRHPFKRI--CMTT 201

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
           D   + ++THY+ +   +            +  V    +TGR HQ+R H+ H+ +P++GD
Sbjct: 202 DSLGKKSITHYKIINRFKF-----------HTHVSFRLETGRTHQIRVHMLHIGYPLLGD 250

Query: 179 SKHGD-------LRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
             +G         ++NR+    F L R  LHA  +   HPFT + ++  A L       L
Sbjct: 251 PLYGGIDYGCNYFQENRNIYRKFNLFRQALHADYIEFIHPFTQKVMSWSASLPQDMKDIL 310

Query: 232 SQF 234
              
Sbjct: 311 LYL 313


>UniRef50_C0GNZ6 Pseudouridine synthase, RluA family n=1 Tax=Desulfonatronospira
           thiodismutans ASO3-1 RepID=C0GNZ6_9DELT
          Length = 535

 Score =  292 bits (749), Expect = 8e-78,   Method: Composition-based stats.
 Identities = 73/270 (27%), Positives = 121/270 (44%), Gaps = 30/270 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQ------IGQHVFTAHRLDR 55
           L+I+Y D  +V +NKP+G  VH S  D    +V                Q     HRLD+
Sbjct: 83  LDIVYMDREMVVLNKPAGLSVHPSSSDPAPTLVHYLLYACPGLRLMTDRQRPGIVHRLDK 142

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADK 114
            T+G+++  L+ EA   LA QF   ++ K Y A+V G L  +E +++ PL  +    A  
Sbjct: 143 DTTGLMVAALNQEAKEDLAGQFAGRRVHKTYLALVCGALKQDEGIINVPLARDQQSRAR- 201

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
                +  + A T Y+ L            P+  + LV+++  TGR HQ+R H +HL HP
Sbjct: 202 -VAPSREGRSARTAYKVLKR---------DPSGLWSLVQVQIFTGRTHQIRVHFSHLNHP 251

Query: 175 IIGDSKHGDLRQNRSGAEH----FGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQA 230
           ++GD  +G    +R G +        +R +LH+S L + HP + + L   +     +++ 
Sbjct: 252 VLGDRIYGGTDWDRFGWKKRFLSRLAKRQLLHSSCLGIMHPVSRQWLEFISRPPRDFIRT 311

Query: 231 LSQFGWRGLLPENERVEFSAPSGQDGEISS 260
           L             + +    +G  G   S
Sbjct: 312 LLWL--------VRKCQKVVVTGSAGCGKS 333


>UniRef50_C8S0A2 Pseudouridine synthase n=1 Tax=Rhodobacter sp. SW2
           RepID=C8S0A2_9RHOB
          Length = 356

 Score =  292 bits (748), Expect = 9e-78,   Method: Composition-based stats.
 Identities = 64/265 (24%), Positives = 100/265 (37%), Gaps = 40/265 (15%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQI-------GQHVFTAHRLD 54
           L ++++D  L+ V+KP G +VH +       +V                 +     HR+D
Sbjct: 99  LTVVWEDADLIVVDKPVGMVVHPAPGSYTGTLVNALLHHCGDTLSGVGGAKRPGIVHRID 158

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL---------------MEEAV 99
           + TSG+L++  +  A   LA QFE H + + Y A+V G                     +
Sbjct: 159 KDTSGLLVVAKTDRAHHGLAAQFEAHSVTRHYIALVHGAPNAADPRLRGIRGVSFEPGGI 218

Query: 100 --LDYPLVEELDKIADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPK 157
             +   L         +    D   + AVT  R L +   P            LVE   +
Sbjct: 219 VCIATNLARHKTDRQRQAVLFDS-GRHAVTRVRVLESYGTPPV--------AALVECWLE 269

Query: 158 TGRKHQLRRHLAHLRHPIIGDSKHGDLRQNRSGA-------EHFGLQRLMLHASQLSLTH 210
           TGR HQ+R H++H  H ++GD  +G  R+    A             R  LHA+ L   H
Sbjct: 270 TGRTHQIRVHMSHAGHALLGDQTYGGRRKVAPKAVGEAVAQAANDFPRQALHAASLGFVH 329

Query: 211 PFTGEPLTIHAGLDDTWMQALSQFG 235
           P +GE L   + L        +   
Sbjct: 330 PVSGEELLFTSPLPADMAALTAALR 354


>UniRef50_UPI00016C3FBA ribosomal large subunit pseudouridine synthase n=1 Tax=Gemmata
           obscuriglobus UQM 2246 RepID=UPI00016C3FBA
          Length = 354

 Score =  292 bits (748), Expect = 1e-77,   Method: Composition-based stats.
 Identities = 70/256 (27%), Positives = 106/256 (41%), Gaps = 28/256 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ-------HVFTAHRLD 54
           L+ILYQDEWL  VNKP+  +VH +  +    +V       +               HRLD
Sbjct: 109 LDILYQDEWLALVNKPADMVVHPAKGNWSGTLVNALQWHFREHLSTGAGHLRAGIVHRLD 168

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEA-VLDYPLVEELDKIAD 113
           + TSGV+L+       R LA QFE  ++ K Y AI  G L  ++  ++  L         
Sbjct: 169 KDTSGVILVAKDDLTHRDLAMQFESRKVFKEYVAIAAGELERDSDYIEGALKMHPYDRLK 228

Query: 114 KFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
                D   + A+++Y  L                + LV+++P+TGR HQ+R HL H+  
Sbjct: 229 MIVSTDPDAKHALSYYEVLERFR-----------GFTLVKVQPRTGRTHQIRVHLLHVGC 277

Query: 174 PIIGDSKHGDLRQ---------NRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLD 224
            ++ D  +G   Q              +   L R  LHA +L   HP TG+ +   A L 
Sbjct: 278 AVLADKIYGGRAQVKLSEIAPGTPPAEDEVLLGRQALHAFRLRFQHPRTGQWIEAEAPLP 337

Query: 225 DTWMQALSQFGWRGLL 240
               + L        +
Sbjct: 338 PDMRRTLDALRQHRAI 353


>UniRef50_Q2S3B7 Pseudouridine synthase n=1 Tax=Salinibacter ruber DSM 13855
           RepID=Q2S3B7_SALRD
          Length = 349

 Score =  292 bits (748), Expect = 1e-77,   Method: Composition-based stats.
 Identities = 67/286 (23%), Positives = 106/286 (37%), Gaps = 54/286 (18%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ---------------- 45
           L+++++ + L+ VNKP+G +VH +   R   +V         G+                
Sbjct: 74  LDVVHEGDDLLVVNKPAGMVVHPAPGHRSGTLVHALLHHVDGGEVAADDERDEVSEDEVG 133

Query: 46  ----------------HVFTAHRLDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAI 89
                                HRLD+ TSG+L++     A + LA+QF+ H + +RY AI
Sbjct: 134 LSLVNALPQSPDHPVVRPGIVHRLDKGTSGLLVVAKRGRAHQPLAEQFKAHTVDRRYRAI 193

Query: 90  VRGWL-MEEAVLDYPLVEELDKIADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTR 148
           V G     +  ++  +  +           +   + A THY  + T              
Sbjct: 194 VWGRFAPSDGTIEGAIGRDPHHRQRMAVVPEDEGKWARTHYETVET-----------HAH 242

Query: 149 YGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHGDLRQNRSGAEHFG----------LQR 198
             +VE E +TGR HQ+R H     HP++GD K+G  R                    L  
Sbjct: 243 TSVVEFELETGRTHQIRVHARAQGHPLLGDPKYGGQRVRYGTQSGTRRTFYDQLFETLPH 302

Query: 199 LMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWRGLLPENE 244
             LHA +L   HP T E L   A     W + L +          +
Sbjct: 303 PALHAYRLGFDHPTTEERLRFEADPPPAWRRVLRELRQEEGAGTTD 348


>UniRef50_A5IBH6 Pseudouridine synthase n=6 Tax=Legionella RepID=A5IBH6_LEGPC
          Length = 321

 Score =  292 bits (748), Expect = 1e-77,   Method: Composition-based stats.
 Identities = 58/245 (23%), Positives = 110/245 (44%), Gaps = 22/245 (8%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRD---QIGQHVFTAHRLDRPTS 58
           ++I+Y+D  ++ VNKP+G +VH    +++  +V          Q+       HRLD+ T+
Sbjct: 87  IQIIYEDSEVIVVNKPAGLVVHPGAGNKEHTLVNALLHHCPELQLLPRAGIIHRLDKDTT 146

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           G+L++  +  +   L +Q +  +I++ Y  +V G+++    +D                +
Sbjct: 147 GLLIVAKNLISHTSLIRQMQNREIKRHYLTLVHGYVISGGTIDTGFGRHPKNRLKMAVTD 206

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
               + AVTHY      +            + L+ +   TGR HQ+R H+ ++ HP++GD
Sbjct: 207 --FGRQAVTHYNINKHYK-----------DFTLLNVSLMTGRTHQIRVHMNYINHPVVGD 253

Query: 179 SKHGDLRQNRSGAEHFGL------QRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALS 232
             +G   +    A+   L      +R  LHA  +S  HP     +T++A L D +   L+
Sbjct: 254 QLYGGRMKFPPNADEAILSVLKQFKRQALHACSISFCHPVKNTEITLNALLPDDFELLLN 313

Query: 233 QFGWR 237
                
Sbjct: 314 TLDQH 318


>UniRef50_B8CQ92 Pseudouridine synthase n=1 Tax=Shewanella piezotolerans WP3
           RepID=B8CQ92_SHEPW
          Length = 278

 Score =  291 bits (747), Expect = 1e-77,   Method: Composition-based stats.
 Identities = 126/236 (53%), Positives = 160/236 (67%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           +EIL++D+ +VA++KP+G LVHRS+L R E+   MQ  RD++G HVF  HRLDRPTSG+L
Sbjct: 27  IEILFEDDDVVAIHKPAGLLVHRSYLARRERFFAMQLTRDKVGCHVFPVHRLDRPTSGIL 86

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKG 121
           L   SSE    L +QF  H I K Y AIVRG + E A LDY L EELD +ADK    +K 
Sbjct: 87  LFAKSSEMANALCEQFAAHSIDKEYLAIVRGNMHEAATLDYALKEELDDVADKDVDPNKA 146

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
            Q A+T Y+ L   E+P A+GRY T+RY LV L P TGRKHQLRRH+AHLRHPI+GD+ H
Sbjct: 147 AQDAITSYKPLLNSEIPYASGRYATSRYALVHLSPHTGRKHQLRRHMAHLRHPILGDTTH 206

Query: 182 GDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWR 237
           GD +QN+   EHFG+ RL L A +LS  HP TGE + +   L+  W+    + GW 
Sbjct: 207 GDGKQNKFFREHFGINRLWLIAKKLSFNHPRTGERVAVETELEQEWITLFDELGWD 262


>UniRef50_A9NGF1 Pseudouridine synthase n=1 Tax=Acholeplasma laidlawii PG-8A
           RepID=A9NGF1_ACHLI
          Length = 297

 Score =  291 bits (746), Expect = 2e-77,   Method: Composition-based stats.
 Identities = 65/242 (26%), Positives = 112/242 (46%), Gaps = 28/242 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVR-------DQIGQHVFTAHRLD 54
           L I+Y+D+ ++ +NKP G +VH S    +  +V             +         HR+D
Sbjct: 76  LNIVYEDDDIMVINKPKGLVVHPSETFSETTLVSGLLHHTDTLSTHNDDPLRPGILHRID 135

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIAD 113
           + TSG++L+  ++EA ++LAQ  + H I++ Y A+V G L   + V+D P+         
Sbjct: 136 KDTSGLILVAKTNEAHKILAQDLKSHDIKREYIALVEGVLDHNKGVIDAPIARHPKIRTK 195

Query: 114 KFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
                    +PA+TH+  + T              + L+  + +TGR HQ+R HLA+++H
Sbjct: 196 MAVV--ATGKPAITHFEVMRTFR-----------DHTLLHCKLETGRTHQIRVHLAYIKH 242

Query: 174 PIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           P+ GD  +G   +             +LHA +L   HP T + + + A L   +   L  
Sbjct: 243 PVTGDPLYGTKAKILK-------DGQLLHAFRLEFVHPITKKVMMLEAPLPPEFESYLVT 295

Query: 234 FG 235
            G
Sbjct: 296 LG 297


>UniRef50_C0QAZ3 RluD1 n=1 Tax=Desulfobacterium autotrophicum HRM2
           RepID=C0QAZ3_DESAH
          Length = 313

 Score =  291 bits (745), Expect = 2e-77,   Method: Composition-based stats.
 Identities = 66/248 (26%), Positives = 111/248 (44%), Gaps = 27/248 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQ--------IGQHVFTAHRL 53
           L+ L++D+W+V VNKP+G +VH    +    ++                        HRL
Sbjct: 81  LDFLHEDQWIVVVNKPAGMVVHPGAGNSSGTLLNALLHHFPSLTDTHCDPPLRGGIVHRL 140

Query: 54  DRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIA 112
           D+ TSG +++  S +A   L ++F   +++KRY A+  G + E +  +  P+        
Sbjct: 141 DKDTSGTIVVAKSKKAYEFLQKEFRFRRVEKRYIALATGIITETQGRITLPIGRHPIHRK 200

Query: 113 DKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLR 172
                 ++  +PA T +R L                + L+++  KTGR HQ+R H   L 
Sbjct: 201 RMAVNTER-ARPAETLWRVLGQ-----------MAGHTLLDVGLKTGRTHQIRVHFRALG 248

Query: 173 HPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALS 232
           HP+ GD  +G       G +     R MLHA  L   HP++G+ +   A L +  ++ L 
Sbjct: 249 HPLAGDRVYG-----FRGKQSARAPRQMLHAGTLGFRHPWSGKRVEFTAPLPEDMVEVLE 303

Query: 233 QFGWRGLL 240
           +   RG L
Sbjct: 304 RLN-RGPL 310


>UniRef50_P54604 Uncharacterized RNA pseudouridine synthase yhcT n=5 Tax=Bacillus
           RepID=YHCT_BACSU
          Length = 302

 Score =  291 bits (745), Expect = 2e-77,   Method: Composition-based stats.
 Identities = 69/236 (29%), Positives = 108/236 (45%), Gaps = 23/236 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG---QHVFTAHRLDRPTS 58
           L+IL++D  ++ +NKP+G   H +   +   +  +     QI      V   HRLD+ TS
Sbjct: 83  LDILFEDNHMLIINKPAGIATHPNEDGQTGTLANLIAYHYQINGETCKVRHVHRLDQDTS 142

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADKFAR 117
           G ++      A  +L QQ E+  +++ Y AI  G L  ++  ++ P+  +      +   
Sbjct: 143 GAIVFAKHRLAHAILDQQLEKKTLKRTYTAIAEGKLRTKKGTINSPIGRDRSHPTRRRV- 201

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
              G Q AVTH++ +A+             R  LVELE +TGR HQ+R HLA L HP+ G
Sbjct: 202 -SPGGQTAVTHFKVMAS---------NAKERLSLVELELETGRTHQIRVHLASLGHPLTG 251

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           DS +G   +         L R  LHA+++   HP T E +   A            
Sbjct: 252 DSLYGGGSK--------LLNRQALHANKVQAVHPITDELIVAEAPFPADMKNLCRT 299


>UniRef50_C1FEQ4 Predicted protein n=2 Tax=Micromonas RepID=C1FEQ4_9CHLO
          Length = 357

 Score =  290 bits (743), Expect = 3e-77,   Method: Composition-based stats.
 Identities = 64/261 (24%), Positives = 104/261 (39%), Gaps = 37/261 (14%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG-------------QHVF 48
           L+++++D+ LV VNKP G +VH S       +V                         + 
Sbjct: 103 LDVVFEDDHLVVVNKPPGMVVHPSAGHAGGSLVNALLFHCNERSNRGDDASKMIDVPRLG 162

Query: 49  TAHRLDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEE 107
             HR+D+ TSG+L+M   + A   L  QF    +++RY AIV G    E   +D P+  +
Sbjct: 163 VVHRIDKGTSGLLVMAKDAAAQAGLQTQFANRSVRRRYLAIVLGTPARESGRIDAPIGRD 222

Query: 108 LDKIADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRH 167
                          + A++++   A +               LVE + +TGR HQ+R H
Sbjct: 223 PADRLKMAIVRGATGRQAISNFGVRARL---------VRGNASLVEWQLETGRTHQIRVH 273

Query: 168 LAHLRHPIIGD--------------SKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFT 213
              + HPI+GD               + G +    +        R MLHA  L   HP T
Sbjct: 274 AREMGHPIVGDEAYGGGGSAAAEFLRRDGAMSAAAAREIVAKCARPMLHARSLGFRHPVT 333

Query: 214 GEPLTIHAGLDDTWMQALSQF 234
           GE ++        ++ A ++ 
Sbjct: 334 GEEISFAVEPPPDFVDAFTEL 354


>UniRef50_D1Y3Y9 Pseudouridine synthase n=1 Tax=Pyramidobacter piscolens W5455
           RepID=D1Y3Y9_9BACT
          Length = 345

 Score =  289 bits (742), Expect = 5e-77,   Method: Composition-based stats.
 Identities = 67/238 (28%), Positives = 105/238 (44%), Gaps = 24/238 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRD------QIGQHVFTAHRLDR 55
            +++Y+D+ ++ VNKP+G +VH      D  +V     R                HRLD 
Sbjct: 116 FDVVYEDDDVIVVNKPAGVVVHPGAGRPDGTLVNGLMFRYPEIGRIGDSVRPGIVHRLDV 175

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADK 114
            TSG++++  S  A R L + F+ H++ K Y  +  G L   E  +D P+  +       
Sbjct: 176 GTSGLMVVARSDAAFRGLTEAFQAHEVLKEYLGLGVGALKAPEGTVDAPIGRDPRNRLKM 235

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
               D   + AVT Y+ L T             R  L+ +   TGR HQ+R H+  L   
Sbjct: 236 CVSWD--GRDAVTDYKVLWT-----------RARCNLIRVRLHTGRTHQIRVHMRALGCS 282

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALS 232
           + GD+ +G     +  A+H    R+ LH+ +L   HP +GE L   A L    + AL 
Sbjct: 283 LDGDTLYGP----KDPAQHILKDRVFLHSWRLGFRHPVSGERLEFRAPLPPELIAALR 336


>UniRef50_C1ZGS9 Pseudouridine synthase n=1 Tax=Planctomyces limnophilus DSM 3776
           RepID=C1ZGS9_PLALI
          Length = 345

 Score =  289 bits (741), Expect = 6e-77,   Method: Composition-based stats.
 Identities = 66/258 (25%), Positives = 105/258 (40%), Gaps = 28/258 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ------HVFTAHRLDR 55
           L+ILY DE+L  +NK +  +VH    +    +                       HRLDR
Sbjct: 91  LDILYDDEYLCVINKTANMIVHPGRGNYRGTLAGALQFHFDSLSDVAGQYRAGIVHRLDR 150

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADK 114
            TSGVL++   +   + L++QFE+  ++K YHAIV G +  +   ++  +          
Sbjct: 151 DTSGVLVVAKDNTVHQHLSRQFEERSVEKEYHAIVWGEMQFDADYVETYVRVSFRNRERM 210

Query: 115 FARED-KGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
                    + A T Y                   +  V+L+P+TGR HQLR H+ HL H
Sbjct: 211 MVCPPGDNARQAATFYEVQQRFR-----------GFTYVKLQPQTGRTHQLRVHMHHLGH 259

Query: 174 PIIGDSKHGDL---------RQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLD 224
           PII D  +             +    A+   + R  LHA +L+  HP T + +   A L 
Sbjct: 260 PIIADRLYEGKTCVKLSDILPETPEEADETLIDRQALHARRLAFNHPVTKKRMVFEAPLP 319

Query: 225 DTWMQALSQFGWRGLLPE 242
             + + L       + P+
Sbjct: 320 ADFQKTLDTLKTHAIKPK 337


>UniRef50_C1A885 Pseudouridine synthase n=1 Tax=Gemmatimonas aurantiaca T-27
           RepID=C1A885_GEMAT
          Length = 329

 Score =  289 bits (740), Expect = 7e-77,   Method: Composition-based stats.
 Identities = 61/241 (25%), Positives = 103/241 (42%), Gaps = 22/241 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRD------QIGQHVFTAHRLDR 55
           L+++Y+DE L+ V+K +G +VH +  +    +V     R                HRLD+
Sbjct: 83  LDVVYEDEHLLVVDKAAGMVVHPAPGNWTGTLVNALLGRGEPLAEGGGEDRAGLVHRLDK 142

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEA-VLDYPLVEELDKIADK 114
            TSG+L++  S  A R L+      Q+ +RY A+  G L EE   ++ P+  +       
Sbjct: 143 DTSGLLVVAKSDAAHRTLSSALAARQVTRRYAAVCWGHLAEERITVEKPIARDPRDRTRM 202

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
                +  + + T +  LA  +              L+     TGR HQ+R HLA   HP
Sbjct: 203 AIV--QSGKASRTDFTRLARFDSVD-----------LLRAHLHTGRTHQIRVHLASTGHP 249

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           ++GD  +               +R  LHA+ L   HP +G+ + + + L      +L+  
Sbjct: 250 VVGDDTY--GGGGGRRLALLPPRRHFLHAAWLRFRHPISGDLIDLRSPLPADLRTSLAAL 307

Query: 235 G 235
           G
Sbjct: 308 G 308


>UniRef50_B7GAM3 Predicted protein (Fragment) n=1 Tax=Phaeodactylum tricornutum CCAP
           1055/1 RepID=B7GAM3_PHATR
          Length = 325

 Score =  289 bits (740), Expect = 7e-77,   Method: Composition-based stats.
 Identities = 66/239 (27%), Positives = 109/239 (45%), Gaps = 21/239 (8%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVR-----DQIGQHVFTAHRLDRP 56
           L+I+++DE ++ +NK +  +VH +  + D  VV           + I       HRLD+ 
Sbjct: 73  LDIIFEDEHMIVINKAANMVVHPAAGNWDGTVVNALAYYLANRSESISFRPGIVHRLDKG 132

Query: 57  TSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFA 116
           T+GVL++  +S+    L+  F   Q++K Y AI  G   +  V+D P+            
Sbjct: 133 TTGVLVVAKTSQTLATLSNFFAARQVKKTYMAITVGNPGKHVVIDKPIGRHPLHRQRMRV 192

Query: 117 REDK-----GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHL 171
             D        + A+++   LA              +  LV++  +TGR HQ+R HL   
Sbjct: 193 VPDPHQKNSTGRRALSYVDTLA-----------FDGKLSLVQVRIETGRTHQIRVHLQDR 241

Query: 172 RHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQA 230
             PI GD  +G    N+  ++   + R +LHA +L + HP TGEP+   A L D   + 
Sbjct: 242 HTPIYGDDIYGLADWNKKLSKTHRIVRPLLHAYKLEINHPVTGEPMVFKASLADDMKRI 300


>UniRef50_B6J6C4 Pseudouridine synthase n=7 Tax=Coxiella burnetii RepID=B6J6C4_COXB1
          Length = 327

 Score =  289 bits (740), Expect = 9e-77,   Method: Composition-based stats.
 Identities = 64/243 (26%), Positives = 107/243 (44%), Gaps = 22/243 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG---QHVFTAHRLDRPTS 58
           L+++Y+DE L+ +NKP G +VH     RD+ ++      D            HRLD+ TS
Sbjct: 89  LDVIYEDETLLVINKPVGLIVHPGAGVRDQTLINALLHYDPSLSVVPRAGIIHRLDKDTS 148

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           G+LL+  +  +   L +  +  QI + Y AIV+G L+    ++ P+              
Sbjct: 149 GLLLIARTLASHHALIKAMKARQIVREYEAIVKGVLISGRTIEAPVGRHPIHRTRMAVV- 207

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
            +  +PA+TH+R +                +  + ++ +TGR HQ+R H+AH+ HP+ GD
Sbjct: 208 -EFGRPAITHFRIIKRYRA-----------HTHIRVQLETGRTHQIRVHMAHIHHPLAGD 255

Query: 179 SKHGDLR------QNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALS 232
             +G          +        L+R  LH + L  +HP    P+  HA L       L 
Sbjct: 256 PVYGSHVGIPVHLSDPLQTALKTLKRQALHGATLQFSHPVDQRPMACHAPLPADMAHLLE 315

Query: 233 QFG 235
              
Sbjct: 316 CLE 318


>UniRef50_O67638 Uncharacterized RNA pseudouridine synthase aq_1758 n=3
           Tax=Aquificaceae RepID=Y1758_AQUAE
          Length = 316

 Score =  289 bits (740), Expect = 9e-77,   Method: Composition-based stats.
 Identities = 61/246 (24%), Positives = 105/246 (42%), Gaps = 19/246 (7%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG------QHVFTAHRLDR 55
           + I+Y+DE +  V KP G +VH S       +V       +        +     HRLD+
Sbjct: 82  INIIYEDEDIAVVEKPCGLVVHPSPGYTSGTLVNALLYHIKDLSSIGGVERPGIVHRLDK 141

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADK 114
            T+GV+++  ++ A R L +QF++ + +K Y  +V+G + ++   +D P+          
Sbjct: 142 ETAGVMVIAKNNTAHRNLVRQFQERKTEKFYKVLVKGLVKKDYGAIDTPIARHPVDRKRF 201

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
           + R  K  + A+T Y  L   E              L++++  TGR HQ+R H A + HP
Sbjct: 202 WVR--KEGKEALTEYWVLKRYEKY---------EITLLKVKIHTGRTHQIRVHFASIGHP 250

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRL-MLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           ++GD  +G    +        +    ML A  L   HP  GE +       +T+    S 
Sbjct: 251 VLGDRTYGFKSSSVPKELLSLMGECNMLIAYHLGFYHPTKGEWMVFEIEEPETFKSVYSW 310

Query: 234 FGWRGL 239
                 
Sbjct: 311 LEEHSP 316


>UniRef50_C7LWM1 Pseudouridine synthase, RluA family n=1 Tax=Desulfomicrobium
           baculatum DSM 4028 RepID=C7LWM1_DESBD
          Length = 526

 Score =  287 bits (737), Expect = 2e-76,   Method: Composition-based stats.
 Identities = 71/264 (26%), Positives = 105/264 (39%), Gaps = 29/264 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRD-----QIGQHVFTAHRLDRP 56
           L + + DE LV VNK     VH +    +  +V            Q G+     HRLD+ 
Sbjct: 82  LNVFFADEDLVVVNKTPAMTVHPAPSVAEPTLVHRVAHHFPALLSQSGERPGIVHRLDKD 141

Query: 57  TSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFA 116
           TSG++++ LS  A   L Q F   ++ K Y A+V G       +   L      I  + A
Sbjct: 142 TSGLIVLALSESARLSLTQAFASREVYKEYLALVAGVPDSSGTVSLALGRHP-SIKTRMA 200

Query: 117 REDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPII 176
             ++G + A T +  L +                LV +   TGR HQ+R H+A L HP++
Sbjct: 201 VVERGGRAAETRFELLWSAADRS---------ASLVRVRIMTGRTHQIRVHMAALGHPLL 251

Query: 177 GDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGW 236
           GD+ + D              R MLHA QL   HP + E +   A   D ++Q L +   
Sbjct: 252 GDAVYADK------QTAARAPRQMLHAWQLRFEHPRSFESMEFCAPPPDDFLQVLRELCR 305

Query: 237 RGLLPENERVEFSAPSGQDGEISS 260
                          +G  G   S
Sbjct: 306 ERAC--------IGLTGAVGSGKS 321


>UniRef50_C1SM47 Pseudouridine synthase n=1 Tax=Denitrovibrio acetiphilus DSM 12809
           RepID=C1SM47_9BACT
          Length = 302

 Score =  287 bits (737), Expect = 2e-76,   Method: Composition-based stats.
 Identities = 59/240 (24%), Positives = 102/240 (42%), Gaps = 23/240 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVR----DQIGQHVFTAHRLDRPT 57
           +EI+Y  +    +NKP+G  VH +    D+ +V          D         HRLD+ T
Sbjct: 81  IEIIYDCDEFAVINKPAGITVHPAPGHADDTIVNAMLAEFDITDDNDLRPGIVHRLDKDT 140

Query: 58  SGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADKFA 116
           SG++++  + ++  +L++ F    I KRY A+  G   E E  ++ P+            
Sbjct: 141 SGLMIVAKNRKSREVLSKVFADRDIDKRYLAVCWGKPKELEFTIEQPIGRHYKDRKRMCV 200

Query: 117 REDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPII 176
           RED   + + +  R L                  L E+   TGR HQ+R H++H   P+ 
Sbjct: 201 RED--GRYSKSGVRVLKQ-----------NNNAFLAEIRIFTGRTHQIRVHMSHAGFPLA 247

Query: 177 GDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGW 236
           GD  +G  +  +       ++R  LH+ +L+   PFTGE +   + L     + +     
Sbjct: 248 GDVVYGHRQSLK-----LPIKRQALHSFRLAFVSPFTGEDMVFESPLPLDMKELIIGLKL 302


>UniRef50_Q7UHX8 Pseudouridine synthase n=1 Tax=Rhodopirellula baltica
           RepID=Q7UHX8_RHOBA
          Length = 334

 Score =  287 bits (737), Expect = 2e-76,   Method: Composition-based stats.
 Identities = 71/257 (27%), Positives = 106/257 (41%), Gaps = 39/257 (15%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQI------GQHVFTAHRLDR 55
           L+ILY+D+ LV +NKP+G +VH +  +    +      R Q              HRLDR
Sbjct: 79  LDILYEDDGLVVINKPAGMVVHPARGNWTGTLTSALAFRFQSLSDVGGPTRPGIVHRLDR 138

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEA-VLDYPLVEELDKIADK 114
            TSGV+++  ++     LA Q+    +QK Y AI  G L  +   +   +     +   +
Sbjct: 139 DTSGVIVVAKNNAVHLNLAAQWHDRLVQKEYTAITFGRLDRDRDWIHASIGRHPYQRDKQ 198

Query: 115 FARE-DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
             RE     + A T Y  +               R   V++ PKTGR HQ+R HLAH+  
Sbjct: 199 AIREGHATSKTASTFYEVVER-----------HGRVTRVDVRPKTGRTHQIRVHLAHIGC 247

Query: 174 PIIGDSKHGDLRQNRSGA--------------------EHFGLQRLMLHASQLSLTHPFT 213
           PI+ D  +G   +                         E   L R  LHA  L+ T+P T
Sbjct: 248 PILCDRLYGGHSELSRSQIRRLAGTEVATPGVKPTPEGEEILLSRQALHAKALTFTNPQT 307

Query: 214 GEPLTIHAGLDDTWMQA 230
           G+ +T+ A L       
Sbjct: 308 GKEMTLTAPLPPDLQAV 324


>UniRef50_A0Q1S9 Pseudouridine synthase n=32 Tax=Clostridium RepID=A0Q1S9_CLONN
          Length = 301

 Score =  287 bits (737), Expect = 2e-76,   Method: Composition-based stats.
 Identities = 67/237 (28%), Positives = 115/237 (48%), Gaps = 24/237 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQH---VFTAHRLDRPTS 58
           L+++Y+D+ +V +NKP G +VH +   ++  +        +       V   +RLD  TS
Sbjct: 83  LDVIYEDKDIVVINKPKGIVVHPTKRHQNGTLSNGVLYYFKEKNENSIVRLVNRLDMDTS 142

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADKFAR 117
           G++L+  ++ +   L++  ++    K Y AIV G L E+  V++ P+    +    +   
Sbjct: 143 GLVLIAKNAYSHMALSRDMQKDDFVKSYLAIVHGNLKEKSGVINKPIYRVGEGTLRR--V 200

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
            D+  Q +VT ++ + + E              LVEL  +TGR HQ+R HL+ + HPI G
Sbjct: 201 IDERGQRSVTRFKVVESYEDAD-----------LVELTLETGRTHQIRVHLSSIGHPIYG 249

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           DS +G         EH  + R  LHA +L + HP  G  L + + L D     +S+ 
Sbjct: 250 DSLYGK-------EEHEYIDRQALHAYKLQIPHPKDGRILKLESDLPDDMKNLISKL 299


>UniRef50_C6J6E3 Pseudouridine synthase n=2 Tax=Bacillales RepID=C6J6E3_9BACL
          Length = 321

 Score =  287 bits (737), Expect = 2e-76,   Method: Composition-based stats.
 Identities = 63/250 (25%), Positives = 107/250 (42%), Gaps = 25/250 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKV---VVMQTVRDQIGQHVFTAHRLDRPTS 58
            +I+Y+DE L+ VNK +G +VH +       +   VV               HRLD+ TS
Sbjct: 85  FDIVYEDEALLIVNKAAGLIVHPTHGHYTGTLANGVVYYWQEKGEKFRFRPVHRLDQETS 144

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADKFAR 117
           G++ +  ++   + +++Q    ++ K+Y A+V G     E  +D P+  +  +   +   
Sbjct: 145 GLIAIAKNAYVHQHISEQLIAGEVTKKYTALVHGCPAVPEGTIDGPIDRDPAEPHRRIVT 204

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
                 P++T+Y+                     VEL   TGR HQ+R H+  + HP+IG
Sbjct: 205 PS--GYPSLTYYKVAEAY-----------GDGARVELRLGTGRTHQIRVHMTSIGHPLIG 251

Query: 178 DSKHG--------DLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQ 229
           D  +G           + R       + R  LHAS+L   HP TGE LT  + L +  ++
Sbjct: 252 DKFYGMPGLAELPAPARERIARLDAAIGRQALHASELGFRHPLTGEALTFKSELPEDMLK 311

Query: 230 ALSQFGWRGL 239
             +       
Sbjct: 312 LEAMLRRASF 321


>UniRef50_D2R7T3 Pseudouridine synthase, RluA family n=1 Tax=Pirellula staleyi DSM
           6068 RepID=D2R7T3_9PLAN
          Length = 355

 Score =  287 bits (736), Expect = 2e-76,   Method: Composition-based stats.
 Identities = 78/248 (31%), Positives = 104/248 (41%), Gaps = 25/248 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQ------IGQHVFTAHRLDR 55
           L+IL++DE L+AVNKP G +VH +       +        Q              HRLDR
Sbjct: 115 LDILFEDEHLIAVNKPPGMVVHPARGHWSGTLTSALAFHFQQLSTVGGQHRPGIVHRLDR 174

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEA-VLDYPLVEELDKIADK 114
            TSGV+++  +      LA QF      K Y AI  G    +  V+  P+          
Sbjct: 175 DTSGVIIVAKTDPVHFSLAAQFADRTTAKEYFAITAGVPDRDRDVVSQPIGIHPFHREKM 234

Query: 115 FARE-DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
             R      + A T +  L       A           VE  PKTGR HQ+R HLAH+R 
Sbjct: 235 AIRPGHSTSRDAETMFHVLERFAQHAA-----------VECLPKTGRTHQIRVHLAHVRT 283

Query: 174 PIIGDSKHGDLRQN------RSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTW 227
           P++ D  +G   +       R G+    L R  LHA +LS+ HP TGE LTI A L    
Sbjct: 284 PVLCDKLYGGRAEITQGELVRDGSTEVVLNRQALHARKLSINHPKTGERLTIEAPLPADL 343

Query: 228 MQALSQFG 235
            + L    
Sbjct: 344 QRVLDLLR 351


>UniRef50_Q2GGY1 Pseudouridine synthase n=13 Tax=Rickettsiales RepID=Q2GGY1_EHRCR
          Length = 337

 Score =  287 bits (735), Expect = 3e-76,   Method: Composition-based stats.
 Identities = 50/251 (19%), Positives = 101/251 (40%), Gaps = 24/251 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG-------QHVFTAHRLD 54
           + ++Y+D  ++ +NK  G  VH      +  +V                       HRLD
Sbjct: 96  ISVVYEDHDIIIINKAPGITVHPGAGTNNNTLVNALVAHYGNSLSHVGKATRPGIIHRLD 155

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIAD 113
           + TSG++++  + ++   L+    + QI+K Y A+V G    +   +   +  + +    
Sbjct: 156 KDTSGLMVIAKNEKSYYFLSDLLLKKQIKKEYLAVVWGLPNPKSNTIKNYICVKPNNKQM 215

Query: 114 KFARE-DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLR 172
                     + A+T Y+   +           +    L++    TGR HQ+R H++++ 
Sbjct: 216 MTVTHLPHKGKLAITEYQTQKSF----------SNIASLIKCRIHTGRTHQIRVHMSYIG 265

Query: 173 HPIIGDSKHGDL-----RQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTW 227
           + IIGD K+G       +  +       L+R  LHA +L  THP +   +  H+ + +  
Sbjct: 266 NSIIGDQKYGKNNSKSVKYAKQSTIINTLKRQALHAYKLGFTHPTSNTYIEFHSYIPNDI 325

Query: 228 MQALSQFGWRG 238
              + +     
Sbjct: 326 QMLIDELEQLS 336


>UniRef50_A0LPH5 Pseudouridine synthase n=1 Tax=Syntrophobacter fumaroxidans MPOB
           RepID=A0LPH5_SYNFM
          Length = 344

 Score =  287 bits (735), Expect = 3e-76,   Method: Composition-based stats.
 Identities = 71/266 (26%), Positives = 116/266 (43%), Gaps = 29/266 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRD------QIGQHVFTAHRLDR 55
           LEIL++D+ ++ +NK  G +VH      +  +V                +     HRLDR
Sbjct: 87  LEILFEDDDVLVLNKAPGVIVHPGAGHEEGTLVHGLLAHCSRLASRGAPRRPGIVHRLDR 146

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADK 114
            TSG L++  S  A   L +QF+ H++ K Y A+V G +      +   +         +
Sbjct: 147 GTSGALMVAKSERAYLELIRQFKHHEVGKEYLALVYGTMAGASGEIRTGMGRHPVDR-KR 205

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
            A  +KG + AV+ ++                    L+ +  KTGR HQ+R HL+H++HP
Sbjct: 206 MAVLEKGGREAVSQWKV-----------AVAWGEVSLLRVVIKTGRTHQIRVHLSHMQHP 254

Query: 175 IIGDSKHGDLRQNRSGAEHFGL-------QRLMLHASQLSLTHPFTGEPLTIHAGLDDTW 227
           ++GD  +G  ++     +   L        R MLHA  L+  HP +G  L+  A L   +
Sbjct: 255 VVGDETYGGGKRKARAVKSDVLRELLMEVDRQMLHAVGLAFRHPVSGADLSFTAPLPPDF 314

Query: 228 MQALSQFGWRGLLPENERVEFSAPSG 253
              L +     +  + E    S PSG
Sbjct: 315 AGLLERIR---ISLQKEGAGRSDPSG 337


>UniRef50_A3HSB5 Pseudouridine synthase n=1 Tax=Algoriphagus sp. PR1
           RepID=A3HSB5_9SPHI
          Length = 237

 Score =  287 bits (735), Expect = 3e-76,   Method: Composition-based stats.
 Identities = 105/244 (43%), Positives = 144/244 (59%), Gaps = 12/244 (4%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           L IL++D+ ++A+NKP+G LVHR+ +   E V  +Q +RDQIG HV   HRLDRPTSG+L
Sbjct: 3   LPILFEDDSIIAINKPAGLLVHRTSIAAQETVFALQILRDQIGMHVHPVHRLDRPTSGIL 62

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADKFAREDK 120
           L     E    L   F + QI+K Y  IVRG    ++A++D+PL  E             
Sbjct: 63  LFAKKEEILPHLKNLFSERQIKKNYLTIVRGIPEQKKALIDHPLKSERSGRL-------- 114

Query: 121 GPQPAVTHYRGLATVEMP-VATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDS 179
             Q A T Y+ ++  E+P   TGRYPT+RY L+ + P+TGR HQ+RRHLAH+RH IIGD 
Sbjct: 115 --QEAQTWYKVISETEIPFDTTGRYPTSRYSLLSVNPETGRTHQIRRHLAHIRHYIIGDK 172

Query: 180 KHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWRGL 239
           KHGD +QN      FGL+ L+LHA +LS  HP T E + I   + + +   L     +  
Sbjct: 173 KHGDNKQNIFFQNQFGLENLLLHAIRLSFNHPITEETIEISCPVPEHFQSILKSLNLQEP 232

Query: 240 LPEN 243
           L  +
Sbjct: 233 LISS 236


>UniRef50_C6JBH1 Pseudouridine synthase n=1 Tax=Ruminococcus sp. 5_1_39BFAA
           RepID=C6JBH1_9FIRM
          Length = 299

 Score =  286 bits (734), Expect = 4e-76,   Method: Composition-based stats.
 Identities = 63/233 (27%), Positives = 110/233 (47%), Gaps = 23/233 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVV--MQTVRDQIGQHVF-TAHRLDRPTS 58
           L I+Y+DE ++ +NKP+   VH S  + +  +         ++    V+   +RLDR T+
Sbjct: 81  LNIIYEDEDILVINKPADMPVHPSAGNYENTLANGIAWYFAEKGEDFVYRCINRLDRDTT 140

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           G L++  +  +  +L+ Q ++ QI + Y A+V G L +   ++ P+      +  +    
Sbjct: 141 GALILAKNPLSAAILSVQMKKRQILRTYLALVDGLLPDSGTINAPIARMEGSVITREVNF 200

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
               + A+THY  LA               Y L EL  +TGR HQ+R H+ ++ HP+ GD
Sbjct: 201 -GTGESAITHYERLA-----------AGKEYSLAELHLETGRTHQIRVHMKYIGHPLPGD 248

Query: 179 SKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
             +          ++  + R  LH+ QL  THP TG+ +   A L   ++ A 
Sbjct: 249 YLY--------NPDYRRINRQPLHSYQLEFTHPTTGKVMLFTAPLPIDFISAF 293


>UniRef50_Q5PAD0 Pseudouridine synthase n=5 Tax=Anaplasma RepID=Q5PAD0_ANAMM
          Length = 327

 Score =  286 bits (734), Expect = 4e-76,   Method: Composition-based stats.
 Identities = 58/256 (22%), Positives = 97/256 (37%), Gaps = 23/256 (8%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG-------QHVFTAHRLD 54
           L+++Y+D  ++ ++K     VH         +      R   G             HRLD
Sbjct: 82  LKVVYEDHDVIVIDKDPYIAVHPGNGIEHHTITNALLARFGAGLQSVGSSSRPGIVHRLD 141

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIAD 113
           + TSG+++   +  A   L+++      +K Y A+  G    +  V+   +         
Sbjct: 142 KDTSGLMVAAKTENAYYRLSEELANQGFKKEYLAVAWGIPCPKRGVIHTNI-RVKRSDIT 200

Query: 114 KFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
                + G +PA T Y     +               L+     TGR HQ+R H++H+ H
Sbjct: 201 MMEAANSGGKPAKTEYEVEQELGEV----------ASLIRCTLHTGRTHQIRVHMSHIGH 250

Query: 174 PIIGDSKHGDLRQN----RSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQ 229
            I+GD K+G   +         +    +R  LHAS L   HP TG+ +   +   D   Q
Sbjct: 251 SIVGDQKYGKNCKKCMRSGVPPDVKNFRRQALHASLLGFRHPSTGKYIEFTSKPADDIQQ 310

Query: 230 ALSQFGWRGLLPENER 245
            +S     G L    R
Sbjct: 311 LISALERAGNLQARNR 326


>UniRef50_D1N7N8 Pseudouridine synthase, RluA family n=1 Tax=Victivallis vadensis
           ATCC BAA-548 RepID=D1N7N8_9BACT
          Length = 323

 Score =  286 bits (734), Expect = 4e-76,   Method: Composition-based stats.
 Identities = 67/247 (27%), Positives = 107/247 (43%), Gaps = 22/247 (8%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQ--------IGQHVFTAHRL 53
             ILY+D+ ++ ++KP+G +VH +  +    VV     R                  HRL
Sbjct: 83  FPILYEDDVMLVIDKPAGVVVHPAAGNPTGTVVNALLGRYPQLAEQLACTTSRPGIVHRL 142

Query: 54  DRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIA 112
           D+ TSG L +  ++ A   L+  F   + +K Y AI RG        L   +        
Sbjct: 143 DKDTSGCLAVAKTANAQFKLSTAFAGRETRKTYLAITRGVPIRRSGELSTLIGRHPVSRQ 202

Query: 113 DKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLR 172
                 ++  + A+T YR          TG       G++ +   TGR HQ+R HLA L 
Sbjct: 203 KMAVV-ERNGKLAITRYRV-------EYTGMLDGVEIGVLAVRILTGRTHQIRVHLASLG 254

Query: 173 HPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALS 232
            P++GD+ +G  R         G++R +LHA +L + HP TG P+   A   +   + L 
Sbjct: 255 VPVLGDAVYGGAR-----TAVAGVERQLLHAWKLCVPHPATGTPMEFTAPPPEDIRRILE 309

Query: 233 QFGWRGL 239
           + G + L
Sbjct: 310 RIGVKTL 316


>UniRef50_Q1J0S8 Pseudouridine synthase n=7 Tax=Deinococci RepID=Q1J0S8_DEIGD
          Length = 341

 Score =  286 bits (733), Expect = 5e-76,   Method: Composition-based stats.
 Identities = 78/246 (31%), Positives = 108/246 (43%), Gaps = 27/246 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVR----------DQIGQHVFTAH 51
           L++LY+DE L+AVNKP G + H +       +V     R             G      H
Sbjct: 97  LDVLYEDEHLIAVNKPPGMVTHPAPGVTSGTLVNALLGRLTLPEQPGAVGPDGYRPGIVH 156

Query: 52  RLDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEA--VLDYPLVEELD 109
           RLD+ TSGV+++  + EA   LA  F+     K Y AI  G    +    ++ P+     
Sbjct: 157 RLDKDTSGVIVVAKTVEAHARLAAAFKDRSTHKTYLAIAAGMWKAQGPVSVNAPVGRHPT 216

Query: 110 KIADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLA 169
                      GP+ A T +  LAT                LV  +P TGR HQ+R HLA
Sbjct: 217 ARQRMTV-GGVGPREAQTLFTPLAT------HPDGHGRTLALVRAQPHTGRTHQIRVHLA 269

Query: 170 HLRHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQ 229
           HL  PI+GD+ +G             + R  LHA  L+L HP TGE L +HA + D  ++
Sbjct: 270 HLGSPILGDAVYG--------RASAVMPRHALHAQFLTLPHPVTGETLHLHAPVPDDLLR 321

Query: 230 ALSQFG 235
           A    G
Sbjct: 322 AWVALG 327


>UniRef50_A8ZXZ8 Pseudouridine synthase n=1 Tax=Desulfococcus oleovorans Hxd3
           RepID=A8ZXZ8_DESOH
          Length = 329

 Score =  286 bits (733), Expect = 5e-76,   Method: Composition-based stats.
 Identities = 66/260 (25%), Positives = 102/260 (39%), Gaps = 27/260 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRD------QIGQHVFTAHRLDR 55
           L +L++D +L+ VNKP G +VH +       +V                      HRLDR
Sbjct: 82  LPLLFEDAFLLVVNKPPGLVVHPAPGHEGGTLVNRLLHHFPAIGTVGEPDRPGIVHRLDR 141

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADK 114
            TSG L++  ++ A + L+  F+  Q++K Y A+V G +     V+  P+     +    
Sbjct: 142 NTSGALVVAKTAAAHQALSDMFKSRQVRKTYLALVYGQMKSTGGVVTLPIGRHSLERKKM 201

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
                   +PA T ++                    L+ELE  TGR HQ+R H   L+ P
Sbjct: 202 SV-SSPQARPAETRWKVRKAFV-----------DASLLELEIHTGRTHQIRVHCTALQRP 249

Query: 175 IIGDSKHGDL--------RQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDT 226
           ++GD  +               S        R MLHA +L   HP TG P+   A L + 
Sbjct: 250 VVGDPTYPCKWTRKRQHFSSRASFELLNAAGRQMLHAWRLEFDHPVTGAPMCFTAPLFED 309

Query: 227 WMQALSQFGWRGLLPENERV 246
             + L            +R 
Sbjct: 310 IKEMLHLLRAIDGTTAPKRA 329


>UniRef50_A4RT55 Predicted protein (Fragment) n=3 Tax=Chlorophyta RepID=A4RT55_OSTLU
          Length = 332

 Score =  286 bits (733), Expect = 6e-76,   Method: Composition-based stats.
 Identities = 63/273 (23%), Positives = 106/273 (38%), Gaps = 57/273 (20%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ---------------- 45
           L+I+++DE ++ VNK +G + H S       +V        + +                
Sbjct: 70  LDIVHEDESVLVVNKAAGMVTHPSAGHESGTLVNAVLGHCDLPELVVPTGNQALSDDDED 129

Query: 46  ----------------HVFTAHRLDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAI 89
                                HRLD+ TSGV+++   + A   L +QF    ++++Y AI
Sbjct: 130 DEDAVDEDEGARDGMIRPGIVHRLDKGTSGVMVVAKDASAHNSLCEQFAARVVRRKYVAI 189

Query: 90  VRGWL-MEEAVLDYPLVEELDKIADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTR 148
           + G     +  ++ P+  +             G + A ++Y  +AT+             
Sbjct: 190 LSGVPSPSKGRIEAPIGRDPRDRLRMAVT-QGGGRFAASNYEVIATL---------ANGN 239

Query: 149 YGLVELEPKTGRKHQLRRHLAHLRHPIIGDS--------------KHGDLRQNRSGAEHF 194
             LVE   +TGR HQ+R H  H+ HPI+GD               ++G      + A   
Sbjct: 240 ASLVEWRLETGRTHQIRVHAKHIGHPILGDDTYGGGGGAAVSALSRYGVFDVKEAKALMS 299

Query: 195 GLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTW 227
            + R MLHA  L  THP +GE L       + +
Sbjct: 300 TIDRPMLHARTLGFTHPQSGEALDFSRDPPEDF 332


>UniRef50_C0QV86 Pseudouridine synthase n=2 Tax=Brachyspira RepID=C0QV86_BRAHW
          Length = 329

 Score =  286 bits (733), Expect = 6e-76,   Method: Composition-based stats.
 Identities = 67/237 (28%), Positives = 107/237 (45%), Gaps = 28/237 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVR------DQIGQHVFTAHRLDR 55
           L+ILY+D++L+ +NKP+G  VH S  +    +V     +          +     HRLD+
Sbjct: 109 LDILYEDKYLLVINKPAGMSVHCSPSEMSGTLVNALLYKIKDFDFVGNKERAGIIHRLDK 168

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADK 114
            TSG++++G ++     + +QF+   I+K YHAIV G L +    ++ P+          
Sbjct: 169 DTSGLMIIGKNANIVSSIQEQFKNRTIKKIYHAIVVGVLKDNYIEINLPIGRHHVYRKKM 228

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
             RED   + A+TH + L                + L+E+  KTGR HQ+R H ++   P
Sbjct: 229 TVRED--GKEALTHIKVLKRF-----------NSHTLIEINLKTGRTHQIRVHSSYKGFP 275

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
           + GD  +       SG        LML A ++   HP T E L       D +   L
Sbjct: 276 VAGDKIYSKSFSKYSG--------LMLVAKKIEFMHPITKELLDFEIDYPDYFTNFL 324


>UniRef50_C4XFS9 Pseudouridine synthase n=2 Tax=Mycoplasma RepID=C4XFS9_MYCFE
          Length = 315

 Score =  285 bits (731), Expect = 9e-76,   Method: Composition-based stats.
 Identities = 60/234 (25%), Positives = 104/234 (44%), Gaps = 26/234 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ-------HVFTAHRLD 54
           L+I Y+D+ LV +NKPS  +VH S    ++ +V       +               HR+D
Sbjct: 84  LDIKYEDDDLVIINKPSNLVVHPSPGHYNDTLVNGLLYHFKNNLSNENGLLRPGIVHRID 143

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAV-LDYPLVEELDKIAD 113
           + TSG+L++  +++    L    ++H+I++ Y AIVRG +      ++ P+         
Sbjct: 144 KDTSGLLIIAKNNKMHNSLTDMLKRHEIERSYLAIVRGLIENPLTKINLPIARNTVDRKM 203

Query: 114 KFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
                 K  + A+T    L    +             LV  E KTGR HQ+R HL++++H
Sbjct: 204 MSV--HKEGKEAITFVHLLKHFYLDKEP-------MSLVRCELKTGRTHQIRVHLSYIKH 254

Query: 174 PIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTW 227
           P+ GD  +G      +           LHA +L   HP T + + ++A +   +
Sbjct: 255 PVYGDPTYGKSVDEFN---------QRLHAYKLKFIHPLTKKEICVYAPVPKEF 299


>UniRef50_Q30SZ1 Pseudouridine synthase n=2 Tax=Proteobacteria RepID=Q30SZ1_SULDN
          Length = 241

 Score =  285 bits (731), Expect = 1e-75,   Method: Composition-based stats.
 Identities = 123/240 (51%), Positives = 167/240 (69%)

Query: 1   MLEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGV 60
           MLEILYQDE LVA+NKPSG LVHRS +DR E    +QT+R+Q+G+ V+  HRLD+PTSGV
Sbjct: 1   MLEILYQDEHLVAINKPSGLLVHRSPIDRHETEFAIQTLRNQLGRFVYPIHRLDKPTSGV 60

Query: 61  LLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDK 120
           LL  L  E+ +++ ++F  H+ +K Y A+VRG+ ++   +DY L  + DKIADK +  DK
Sbjct: 61  LLFALDKESAKIMGEKFMAHEAKKSYIAVVRGYTLQSGEIDYALSIKFDKIADKDSSSDK 120

Query: 121 GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSK 180
            PQ A+THY+ LATVE+    G+Y  TRY LV+L P TGRKHQLRRH+ H+ H I+GD+K
Sbjct: 121 EPQEALTHYKRLATVELDFEVGKYDKTRYSLVKLNPLTGRKHQLRRHMKHISHHILGDTK 180

Query: 181 HGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWRGLL 240
           +G    N+   + FG  R++LHA  L ++HP+T E L I A LD T+++  S FGW   L
Sbjct: 181 YGRGEHNKLIRQEFGCHRMLLHAIALEISHPYTKELLYIKAPLDVTFIEMFSFFGWDKSL 240


>UniRef50_B0K860 Pseudouridine synthase n=11 Tax=Thermoanaerobacterales
           RepID=B0K860_THEP3
          Length = 285

 Score =  285 bits (730), Expect = 1e-75,   Method: Composition-based stats.
 Identities = 58/236 (24%), Positives = 109/236 (46%), Gaps = 27/236 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKV---VVMQTVRDQIGQHVFTAHRLDRPTS 58
           L+I Y+DE ++ VNKP+  +VH +   +   +   V        +   +   +RLDR TS
Sbjct: 74  LDICYEDEEILIVNKPANMVVHPTKRYQSGTLANGVAWYFKEKGLKALIRPVNRLDRGTS 133

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           G+++          L        + K Y A+V G +  E  +D P+  +     ++    
Sbjct: 134 GLVVFAKRPFMQYYLQII---KPMTKLYFAVVEGKMEGEGRIDLPISRKPQSGIERMV-- 188

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
            +    A+T+Y+ +             + R+ L++++ +TGR HQ+R HL+H+ HPI+GD
Sbjct: 189 SEEGDRAITNYKVVK-----------SSKRFSLLKVKIETGRTHQIRVHLSHIGHPIVGD 237

Query: 179 SKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           + +G             ++R  LHA +L+  HP   + +++++ L       L  F
Sbjct: 238 TLYGSSDD--------YIKRQALHAYRLTFVHPLEEKSISVYSPLPQDIQNLLKLF 285


>UniRef50_C2D7A7 Pseudouridine synthase n=1 Tax=Atopobium vaginae DSM 15829
           RepID=C2D7A7_9ACTN
          Length = 338

 Score =  284 bits (728), Expect = 2e-75,   Method: Composition-based stats.
 Identities = 57/253 (22%), Positives = 106/253 (41%), Gaps = 18/253 (7%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRD--------QIGQHVFTAHRL 53
           L+I Y+D++L+ ++K +G + H S    D+ +                Q        HRL
Sbjct: 86  LDIRYEDDYLLVISKQTGLVCHPSPGHVDDTLSNALVAHCGYEHLGLLQGDDRPGIVHRL 145

Query: 54  DRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIA 112
           D  T+G+++    +   + L          +RY  +V+G++  +E  +   +        
Sbjct: 146 DMDTTGLMVAAKDNTTQQALQDLIRLRVFDRRYIVLVQGYVTPDEGTITTGIARSKKNRL 205

Query: 113 DKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLR 172
                +D   + A+T ++ L   E            Y L+E    TGR HQ+R H+ ++ 
Sbjct: 206 KMCISKDPASREAITTFKTLERFE-----AGSKDDGYSLLECHLYTGRTHQIRVHMRYVG 260

Query: 173 HPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALS 232
           H ++GD  +G     +  A + GLQR  LH+ ++S  HP T E L     L     + L+
Sbjct: 261 HSVVGDPLYGR----KGDALNQGLQRQFLHSWRMSFDHPITHEHLQFCDKLPSDLSEVLA 316

Query: 233 QFGWRGLLPENER 245
           +   + +    + 
Sbjct: 317 RLQPQSMGRTAQG 329


>UniRef50_Q15QZ8 Pseudouridine synthase n=5 Tax=Bacteria RepID=Q15QZ8_PSEA6
          Length = 252

 Score =  284 bits (727), Expect = 3e-75,   Method: Composition-based stats.
 Identities = 129/251 (51%), Positives = 163/251 (64%), Gaps = 2/251 (0%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           L ILYQDE LVA++KP+G LVHRS +DR E    MQ +RDQIGQHVF  HRLDRPTSGVL
Sbjct: 3   LTILYQDECLVAIHKPAGLLVHRSMIDRHETQFAMQMLRDQIGQHVFPVHRLDRPTSGVL 62

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKG 121
           +  LS++  RLL +QF  + I K Y AIVRG + E  ++DY L E+LDKIADK A++DK 
Sbjct: 63  VFALSADIARLLGEQFAGNTIAKTYFAIVRGHVKEAGLIDYALKEKLDKIADKRAKQDKD 122

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
            Q A T Y  L   E+P A  RYP+ RY LV L PKTGRKHQLRRH+ H+ HPI+GD+ H
Sbjct: 123 AQEAQTEYVPLQQFELPFAVSRYPSARYTLVRLHPKTGRKHQLRRHMCHINHPIVGDTTH 182

Query: 182 GDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWRGLLP 241
           GD + N+   + F    L L   Q+ +THP + E L I    D      + Q+GW   LP
Sbjct: 183 GDGKHNKFMRDQFSFNGLALTCQQMCMTHPVSNEKLAIVNDFDQRMSTLMVQWGWE--LP 240

Query: 242 ENERVEFSAPS 252
             +R++  + S
Sbjct: 241 SLDRLDLLSNS 251


>UniRef50_C6CWL6 Pseudouridine synthase n=2 Tax=Paenibacillus RepID=C6CWL6_PAESJ
          Length = 316

 Score =  284 bits (727), Expect = 3e-75,   Method: Composition-based stats.
 Identities = 67/242 (27%), Positives = 107/242 (44%), Gaps = 18/242 (7%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQ-IGQHVF--TAHRLDRPTS 58
           L I+++D++L+ VNKP+G +VH +       +        Q  G+ V     HRLD  TS
Sbjct: 89  LSIVFEDDYLLVVNKPAGIIVHPTKGHYTNTLANGIVHHWQVRGERVRFRPVHRLDEDTS 148

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADKFAR 117
           G++++  +    + L++Q +   I K Y A V G     +  +  P+    +    +   
Sbjct: 149 GLVVIAKNPYIHQQLSEQLQAGTIMKIYCAYVYGTPSPADGTVGAPIDRNPEDPHVRIVT 208

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
            +    P+VTHY+  A              +   V L+ +TGR HQ+R H+ H+  P+IG
Sbjct: 209 PE--GYPSVTHYKTAAVFG---------GGQASKVRLKLETGRTHQIRVHMKHIGCPLIG 257

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWR 237
           D  +G L+  +         R  LHA  L LTHP T E     A L    +Q   +   R
Sbjct: 258 DGMYG-LQTGKVDEWETAAGRQALHAETLGLTHPMTKEWSEWTAALPPDLVQL--ELALR 314

Query: 238 GL 239
             
Sbjct: 315 EC 316


>UniRef50_UPI0001C42CC7 hypothetical protein BpOF4_01845 n=1 Tax=Bacillus pseudofirmus OF4
           RepID=UPI0001C42CC7
          Length = 322

 Score =  283 bits (725), Expect = 4e-75,   Method: Composition-based stats.
 Identities = 64/237 (27%), Positives = 103/237 (43%), Gaps = 25/237 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVM---QTVRDQIGQHVFTAHRLDRPTS 58
           L+I Y+D+ L+ +NKP G     S       +            I       +RLDR TS
Sbjct: 105 LDIHYEDDHLLVINKPQGMPTIPSREHPSRTLANAVMGYYESHHIPFTFHAVNRLDRDTS 164

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADKFAR 117
           G+L++     A   L++     ++++ Y A+  G++   E  +  P+      I ++   
Sbjct: 165 GLLVVAKHGLAHDQLSKGQRAGKLKRYYLALAEGFVQPREGTIHAPIKRRPSSIIERMVA 224

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
            D   Q A+THY+ +                Y  VE+  +TGR HQ+R H AHL HP++G
Sbjct: 225 AD--GQEAITHYKVI-----------NDNQAYSEVEINLETGRTHQIRVHFAHLGHPLLG 271

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           D  +G   +         L R  LH  ++ L HPFTG+ L   A L    ++   + 
Sbjct: 272 DDLYGGSIE--------LLARQALHCQRVELIHPFTGKHLHFSAPLPKDLIEVKDKL 320


>UniRef50_Q2NIN6 Pseudouridine synthase n=4 Tax=Candidatus Phytoplasma
           RepID=Q2NIN6_AYWBP
          Length = 306

 Score =  283 bits (725), Expect = 4e-75,   Method: Composition-based stats.
 Identities = 63/238 (26%), Positives = 107/238 (44%), Gaps = 25/238 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG-----QHVFTAHRLDRP 56
           L+I+Y+D +L  +NKP+  +VH S   +   +V     +         Q     HRLD+ 
Sbjct: 82  LDIIYEDPYLAVINKPANLVVHPSLSFQKTTLVNGLLHQFNTLSHIDTQRPGIVHRLDKN 141

Query: 57  TSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFA 116
           T+G+L++  +++    L   F+Q +I K Y A++ G+L ++ ++  P+            
Sbjct: 142 TTGLLIVAKTNDVSDKLQIAFQQRKITKIYWALIEGFLEDKGIIKLPIGRNNHNRLKMQV 201

Query: 117 REDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPII 176
             D   + AVTH++ L              + + L+E   +TGR HQLR H + L+HPI+
Sbjct: 202 MPD--GKTAVTHFKTLQRF-----------SHFSLMECNLETGRTHQLRAHFSFLKHPIV 248

Query: 177 GDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           GD  +                   LH+  L   HP T + L + A L   + + L  F
Sbjct: 249 GDLLYDSSHHITPL-------GQFLHSKILKFNHPITNQNLILEAPLPTNFEKLLKTF 299


>UniRef50_A5IZB6 Pseudouridine synthase n=4 Tax=Mycoplasma RepID=A5IZB6_MYCAP
          Length = 305

 Score =  283 bits (725), Expect = 4e-75,   Method: Composition-based stats.
 Identities = 63/234 (26%), Positives = 113/234 (48%), Gaps = 26/234 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ-------HVFTAHRLD 54
           L+I Y+DE+L+ +NKPSG +VH +    ++ +V       +           +   HR+D
Sbjct: 76  LDIRYEDEYLLILNKPSGLVVHPAPGHLNDTLVNALMYHFKNNLSDANGLLRLGIVHRID 135

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAV-LDYPLVEELDKIAD 113
           + TSG+L++   +E    LA+  + HQI++ Y AI  G L  +   ++ P+  +      
Sbjct: 136 KDTSGLLIIAKDNETHNELAKMLKNHQIKRTYLAICEGILPNKTTKINLPIQRDTKNRKL 195

Query: 114 KFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
               +D   + +VT+   L +  +           Y LV+ E +TGR HQ+R HLA+++H
Sbjct: 196 MSIHKD--GKSSVTYVHMLKSFYI-------DNKPYSLVKCELETGRTHQIRVHLAYIKH 246

Query: 174 PIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTW 227
           P+ GDS +G      +           LHA +LS  HP   + + +++ +   +
Sbjct: 247 PVYGDSIYGKSVDEFN---------QRLHAYKLSFMHPVINKLIEVYSDIPKEF 291


>UniRef50_C5TPY8 Pseudouridine synthase n=6 Tax=Proteobacteria RepID=C5TPY8_NEIFL
          Length = 264

 Score =  282 bits (724), Expect = 5e-75,   Method: Composition-based stats.
 Identities = 127/239 (53%), Positives = 161/239 (67%), Gaps = 3/239 (1%)

Query: 1   MLEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGV 60
           ML+I+++D   +AVNKP+G LVHRSWLD+ E    +QT+RDQIGQHV+  HRLDRPTSGV
Sbjct: 27  MLDIIHRDSRTIAVNKPAGMLVHRSWLDKHETRFAVQTLRDQIGQHVYPVHRLDRPTSGV 86

Query: 61  LLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDK 120
           LL  L +EA RLL QQFE   I+K Y AIVRG+L  + ++DY L    DKIA+  A+ + 
Sbjct: 87  LLFALDTEAARLLTQQFENKTIEKTYWAIVRGYLPSDGLIDYALKYMPDKIAE--AQTEA 144

Query: 121 GPQPAVTHYRGLATVEMPVATG-RYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDS 179
             Q A T YR LA  E+P  +  RYPT+RY   EL P TGRKHQLRRH+ H+ HPI+GD+
Sbjct: 145 TLQEAQTAYRCLAQTELPFQSALRYPTSRYSWAELTPYTGRKHQLRRHMKHIFHPIVGDT 204

Query: 180 KHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWRG 238
            +GDLRQN + AEH G QRLMLHA  LS      G  +T++A  D+ W   + +F    
Sbjct: 205 NYGDLRQNHAVAEHIGTQRLMLHARSLSFQSIEDGSRITVNAPTDNDWRLWMEKFKTEA 263


>UniRef50_C4KBT4 Transaldolase n=2 Tax=Proteobacteria RepID=C4KBT4_THASP
          Length = 648

 Score =  282 bits (724), Expect = 5e-75,   Method: Composition-based stats.
 Identities = 124/272 (45%), Positives = 164/272 (60%), Gaps = 24/272 (8%)

Query: 1   MLEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGV 60
           MLEILY+D+WLVA++KPSG LVHRS +   E+   +Q +RDQ+G+ V+ AHRLDR TSGV
Sbjct: 1   MLEILYRDDWLVAIHKPSGLLVHRSPIAAHEERFAVQLLRDQLGRRVYPAHRLDRGTSGV 60

Query: 61  LLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAR--- 117
           LL  L  E  R LAQ+FE   + KRY A+VRG   E  V+++ LV  LD +  +  +   
Sbjct: 61  LLFALDREVARTLAQRFEAQAVDKRYLAVVRGHPPEHGVIEHALVRRLDAVEVRSGKGAG 120

Query: 118 -----------------EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGR 160
                             +   QPA T +R LATVE+P A  RYP++RY LVEL P+TGR
Sbjct: 121 ARDALPEDVDDSDSPEAAEPVAQPARTRFRRLATVELPHAVDRYPSSRYALVELLPETGR 180

Query: 161 KHQLRRHLAHLRHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIH 220
           +HQLRRHL H+ HPIIGD+ +G  R NR     FG  RL+L  ++L+L HP T  PL I 
Sbjct: 181 RHQLRRHLKHIAHPIIGDATYGKGRHNRLFQALFGSHRLLLACTRLALAHPVTERPLEIV 240

Query: 221 AGLDDTWMQALSQFGWRGLLPENERVEFSAPS 252
           A + + +   L+  GW+      +R  F A S
Sbjct: 241 APVAEDFAAVLAALGWQTA----QRSTFEAES 268


>UniRef50_C8P3R0 Pseudouridine synthase n=1 Tax=Erysipelothrix rhusiopathiae ATCC
           19414 RepID=C8P3R0_ERYRH
          Length = 308

 Score =  282 bits (724), Expect = 6e-75,   Method: Composition-based stats.
 Identities = 64/242 (26%), Positives = 111/242 (45%), Gaps = 27/242 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDE-KVVVMQTVR-----DQIGQ-HVFTAHRLD 54
           L+I+Y+D+ ++ VNKP G +VH S    ++  +V           D  G+      HR+D
Sbjct: 83  LDIVYEDDAILVVNKPKGLIVHPSPSTLNQPTLVHGLLAHTTQLSDLNGELRPGIVHRID 142

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIAD 113
           + T+G+L++  ++EA  +L +  +Q  I + Y AIV      + A +D P+  +      
Sbjct: 143 KDTTGLLVVAKTNEAHEILVEDLKQRLISREYVAIVHHQFKHQSATVDAPIGRDPKNRQR 202

Query: 114 KFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
                D+  + AVTH+                   + ++  +  TGR HQ+R H  +++H
Sbjct: 203 MAVT-DQNSKQAVTHFYLAERF-----------NDFSVLRCKLDTGRTHQIRVHAQYIKH 250

Query: 174 PIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           PI+GD  +       S    +      LHA +L+LTHP + E +T  A L  T    + +
Sbjct: 251 PIVGDQTY-------SYKNTWETNGQCLHAQKLTLTHPVSKEVMTFEAELPQTMKDVIEE 303

Query: 234 FG 235
             
Sbjct: 304 IR 305


>UniRef50_B7GLK3 Pseudouridine synthase n=11 Tax=Bacillaceae RepID=B7GLK3_ANOFW
          Length = 292

 Score =  282 bits (724), Expect = 6e-75,   Method: Composition-based stats.
 Identities = 68/234 (29%), Positives = 115/234 (49%), Gaps = 25/234 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRD---QIGQHVFTAHRLDRPTS 58
           L I+Y+D++++ +NKP       S       +           Q+   V    RLDR TS
Sbjct: 80  LAIVYEDDYVIVINKPPHMSTIPSREHPHGTLANALLHHYEQQQLQTTVHVVTRLDRDTS 139

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADKFAR 117
           G++L+        LL++Q +Q ++++RY A+  G++++    +D P+  + D I ++  R
Sbjct: 140 GLVLVAKHRHVHHLLSEQQKQGRVKRRYEAVCHGYVIQLVGTIDAPIGRKGDSIIEREVR 199

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
            D   Q AVTHY  L                   V ++ +TGR HQ+R H +H+ HP++G
Sbjct: 200 LD--GQRAVTHYEVLQQ-----------KNEMTHVSIQLETGRTHQIRVHFSHIGHPLVG 246

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
           D  +G LR++        + R  LH+ +L+  HPF  + +T HA L D   + L
Sbjct: 247 DDLYGGLREH--------IDRQALHSCELTFFHPFFEKTMTFHAPLPDDIARLL 292


>UniRef50_C0Q9S8 TruC n=1 Tax=Desulfobacterium autotrophicum HRM2 RepID=C0Q9S8_DESAH
          Length = 260

 Score =  282 bits (723), Expect = 7e-75,   Method: Composition-based stats.
 Identities = 113/244 (46%), Positives = 140/244 (57%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           LEILYQDE LVAVNKP G LVHR+ L   E    +Q VRDQ   HVF  HRLDRPT GVL
Sbjct: 13  LEILYQDEDLVAVNKPPGLLVHRTALATHETRFALQMVRDQTQGHVFPVHRLDRPTQGVL 72

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKG 121
           L   +      ++  F+  +IQK Y A+VRG + E   + +PL        +K       
Sbjct: 73  LFARNRNMATRMSHLFQTGKIQKTYLAVVRGHVKERGTIVHPLKNIKHPQDNKRINHSLK 132

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
              AVT Y  LA+VE+P    RYPTTRY LV L PKTGR+HQLRRH+ H+ HPI+GD+ +
Sbjct: 133 IDDAVTDYACLASVELPFYVDRYPTTRYCLVALIPKTGRRHQLRRHMKHISHPIVGDTVY 192

Query: 182 GDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWRGLLP 241
           G    NR  A H     L+L A +L   HP TG  +TI A LD  + + +S+F W     
Sbjct: 193 GKSSHNRFFATHLNCTGLLLAARELCFVHPDTGIFITITAPLDKRFQEVISKFSWDEPTK 252

Query: 242 ENER 245
           E  R
Sbjct: 253 ELPR 256


>UniRef50_D1CBT6 Pseudouridine synthase n=1 Tax=Thermobaculum terrenum ATCC BAA-798
           RepID=D1CBT6_THET1
          Length = 313

 Score =  282 bits (723), Expect = 7e-75,   Method: Composition-based stats.
 Identities = 68/238 (28%), Positives = 107/238 (44%), Gaps = 27/238 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRD-----QIGQHVFTAHRLDRP 56
           L ++Y+D+ ++ ++KP+G +VH S    D  +V     R      Q        HRLD+ 
Sbjct: 91  LRVVYEDDKIIVIDKPAGMVVHPSPGHYDNTLVNALIARYPDLLKQPTDRPGIVHRLDKD 150

Query: 57  TSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADKF 115
           TSG++++    +    L  Q +  +I K Y  +  G L   E  ++ P+  +L       
Sbjct: 151 TSGLIIVARDLDTLNYLQGQMKARKIFKEYTLLCCGALDPPEGRIEAPIGRDLRDRTKMS 210

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
                G + AVT Y  + ++            +Y L    P TGR HQ+R H A + HPI
Sbjct: 211 VI--AGGKEAVTEYSTIQSL-----------GKYTLAIARPITGRTHQIRVHFAAIGHPI 257

Query: 176 IGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
            GD  +G+ R         GL R  LHAS+L +  P  GE    H+ L +   Q+L +
Sbjct: 258 AGDPIYGNCRLE-------GLNRQFLHASRLGVVMP-NGEYKEWHSPLPEDLRQSLEK 307


>UniRef50_Q01Q94 Pseudouridine synthase n=1 Tax=Candidatus Solibacter usitatus
           Ellin6076 RepID=Q01Q94_SOLUE
          Length = 296

 Score =  282 bits (723), Expect = 8e-75,   Method: Composition-based stats.
 Identities = 72/240 (30%), Positives = 107/240 (44%), Gaps = 27/240 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRD------QIGQHVFTAHRLDR 55
           L ILY+D  +VA++KP+G +VH         +V     R                HRLDR
Sbjct: 77  LRILYEDADVVAIDKPAGMVVHAGAGVHSGTLVNALLHRFATLSGVGGPLRPGIVHRLDR 136

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADK 114
            TSGVLL+  +  A + LA QF   +I+K Y A+V G +  E   ++ P+  +    A  
Sbjct: 137 FTSGVLLVAKNDAAHQKLAAQFSGREIEKVYLALVHGTVKPETGRIERPIARDPVHRARM 196

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
            AR  +  + A + YR L                + L+E+   TGR HQ+R HLA +RHP
Sbjct: 197 TARLAE-GRAAWSEYRVLRRFP-----------DFTLLEVRIGTGRTHQIRVHLASIRHP 244

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           ++GD+ +G             L R  LHA ++    P +G  + I + L       L   
Sbjct: 245 VVGDTLYG-------APAQPLLGRYFLHAHRIRFHLP-SGREMLIESPLPPDLEAWLGTL 296


>UniRef50_A1K5H7 Pseudouridine synthase n=5 Tax=Proteobacteria RepID=A1K5H7_AZOSB
          Length = 260

 Score =  282 bits (722), Expect = 9e-75,   Method: Composition-based stats.
 Identities = 117/257 (45%), Positives = 154/257 (59%), Gaps = 3/257 (1%)

Query: 1   MLEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGV 60
           MLEILYQDE LVA++KPSG LVHRS LD  E+   +Q +RDQ+G+HV   HRLD+ TSGV
Sbjct: 1   MLEILYQDEHLVAIHKPSGLLVHRSALDAHEERFAVQLLRDQLGRHVHPVHRLDKGTSGV 60

Query: 61  LLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDK 120
           L+  L  +    LA QFE   ++K+Y AIVRG   E   +D+PL    D +      +  
Sbjct: 61  LVFALDRDTAGRLATQFETRAVRKQYVAIVRGHPAEAGTIDHPLSRRFDPVEHVAEDKVF 120

Query: 121 GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSK 180
            PQPA+T +R LAT E+P A  RYPT+RY L+ LEP+TGR+HQ+RRHL H+ HPIIGDS 
Sbjct: 121 APQPAITRFRRLATAELPWAVDRYPTSRYALLALEPETGRRHQIRRHLKHISHPIIGDST 180

Query: 181 HGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWRGLL 240
            G  + NR    HFG +R++L  + + L HP    PL +HA     +       GW   L
Sbjct: 181 FGKGKHNRMFQAHFGSERMLLACTDIELRHPQRDAPLQLHAAPAPDFRAVADALGWHDAL 240

Query: 241 PENERVEFSAPSGQDGE 257
               R+     +G +  
Sbjct: 241 A---RLPADGDTGHNAC 254


>UniRef50_C5J6Q2 Pseudouridine synthase n=1 Tax=Mycoplasma conjunctivae HRC/581
           RepID=C5J6Q2_MYCCR
          Length = 306

 Score =  282 bits (722), Expect = 1e-74,   Method: Composition-based stats.
 Identities = 60/235 (25%), Positives = 105/235 (44%), Gaps = 26/235 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRD-------QIGQHVFTAHRLD 54
            EI+YQD  ++ +NKP   +VH    + D+ +V                       HRLD
Sbjct: 82  FEIVYQDNDIIVINKPKNLVVHPGNGNWDKTLVNGLLHEFATNLSDVNGEIRPGIVHRLD 141

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEA-VLDYPLVEELDKIAD 113
           + TSG+LL+  +++A + LA+Q E H+I+++Y AIV G +      ++ P+  +      
Sbjct: 142 KDTSGLLLVAKNNQAHKYLAKQLENHEIERKYIAIVVGKIPHTKMRINLPIGRDNQNRTK 201

Query: 114 KFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
           K        + A+T+   + T         Y    + +V+   +TGR HQ+R HL+H+ +
Sbjct: 202 K-VVSSFNSKNAITNVELINTF-------VYKNEHFSIVKCILETGRTHQIRVHLSHIGY 253

Query: 174 PIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWM 228
           PI GD  +G    +             LHA +++  H   G  +     + D + 
Sbjct: 254 PIYGDPVYGKKIDDL---------GQRLHAYEITFKH-LDGRLMNFKTEMPDEFK 298


>UniRef50_B1ZYX0 Pseudouridine synthase n=4 Tax=Verrucomicrobia RepID=B1ZYX0_OPITP
          Length = 311

 Score =  281 bits (721), Expect = 1e-74,   Method: Composition-based stats.
 Identities = 66/245 (26%), Positives = 107/245 (43%), Gaps = 23/245 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG-------QHVFTAHRLD 54
           L +L++D+ ++AVNK +G +VH      ++ +V                 +     HRLD
Sbjct: 80  LTVLFEDKHMLAVNKAAGMVVHPGVATSEDTLVHALLAHCAGSLSGIGGVERPGIVHRLD 139

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIAD 113
           + T+GV+++  +  A R LA QF    ++K Y A+V G        +D  +         
Sbjct: 140 KETTGVIVVAKTDAAHRALADQFATRTLKKEYVALVAGVPRLLSGSIDRAIARHPVHRHR 199

Query: 114 KFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
                 +G +PA T +  +                  LV     TGR HQ+R HL  L H
Sbjct: 200 MTV--GEGGRPARTDWELVEAFGDIG----------ALVRCRIFTGRTHQIRVHLKSLGH 247

Query: 174 PIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           PI+GD+ +G   + R   +     R+MLHA  L LTHP +G+ L + A L   ++  + +
Sbjct: 248 PILGDALYGWKPEPRLATQPA---RVMLHAEHLVLTHPISGKELDLRAPLPKDFVAMIKE 304

Query: 234 FGWRG 238
                
Sbjct: 305 LRRSA 309


>UniRef50_A9IIW7 Pseudouridine synthase n=5 Tax=Bordetella RepID=A9IIW7_BORPD
          Length = 324

 Score =  281 bits (721), Expect = 1e-74,   Method: Composition-based stats.
 Identities = 63/238 (26%), Positives = 95/238 (39%), Gaps = 17/238 (7%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHV---FTAHRLDRPTSGV 60
           ++ +    + V+KP+G + H    +    ++     R      V      HRLD+ TSG+
Sbjct: 101 VVAESPDWIVVDKPAGLVTHPGAGNWSGTLLNGLLHRYPELARVARAGIVHRLDKDTSGL 160

Query: 61  LLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDK 120
           +++  +  A   L +Q +   + + Y A+  GWL     +D P+  +             
Sbjct: 161 MVVARNELAQTHLVRQLQARSMGREYIALAHGWLPVAGKVDRPIGRDARVPVRMSVERPI 220

Query: 121 GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSK 180
            P+PA+THY  L         GR P      V    +TGR HQ+R HLA L HP++ D+ 
Sbjct: 221 APKPAITHYAPLRR-------GRAPDGPVTEVACRLETGRTHQIRVHLASLGHPLLADTL 273

Query: 181 HGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWRG 238
           +G            G  R MLHA  L    P  G P    A   D   Q      W  
Sbjct: 274 YGGR-------LTAGATRQMLHARALHFDDPGGGGPAAFRADPPDDMRQVQEALQWSE 324


>UniRef50_C9RQF0 Pseudouridine synthase, RluA family n=1 Tax=Fibrobacter
           succinogenes subsp. succinogenes S85 RepID=C9RQF0_FIBSS
          Length = 424

 Score =  281 bits (720), Expect = 1e-74,   Method: Composition-based stats.
 Identities = 59/267 (22%), Positives = 102/267 (38%), Gaps = 31/267 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ-------HVFTAHRLD 54
           L I+Y+D+ +V +NKP   +VH         +        +               HRLD
Sbjct: 78  LNIVYEDDDIVVINKPRNLVVHPGNGVSKGTLAAALLYHFKENLSTVNGPLRPGIVHRLD 137

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIAD 113
           + T G++++  +  A R LA Q E   + + Y+A+V G   + E  +D P+         
Sbjct: 138 KDTPGLMVVAKNDAAHRHLAHQLETRTLHRTYNALVWGCPRDLEGTIDAPIGRNPKNRLK 197

Query: 114 KFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
                 KG + + THY                     L+EL+ ++GR HQ+R H  +  H
Sbjct: 198 MAVV--KGGKESRTHY-VAKQFFAI----------ATLLELQLESGRTHQIRVHSRYTGH 244

Query: 174 PIIGDSKHGDLRQN--------RSGAEHFG--LQRLMLHASQLSLTHPFTGEPLTIHAGL 223
           P++GD  +    ++        +  AE         +L A ++ L HP T + LT    +
Sbjct: 245 PVVGDPLYDGRDESLNRVPPLMKPVAEKVLEIAPAQLLQAVKIELIHPRTNKKLTFKVPM 304

Query: 224 DDTWMQALSQFGWRGLLPENERVEFSA 250
           ++ +   L               E   
Sbjct: 305 EEPFANVLKLLKKECPASAPVYDEEEG 331


>UniRef50_Q89AD9 Ribosomal large subunit pseudouridine synthase D n=1 Tax=Buchnera
           aphidicola (Baizongia pistaciae) RepID=RLUD_BUCBP
          Length = 317

 Score =  281 bits (720), Expect = 2e-74,   Method: Composition-based stats.
 Identities = 54/244 (22%), Positives = 108/244 (44%), Gaps = 22/244 (9%)

Query: 1   MLEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQ---IGQHVFTAHRLDRPT 57
            L ++Y+D+ ++ +NK   ++VH    +    ++     RD            HRLD+ T
Sbjct: 84  FLNVIYEDDDILVINKQDNFVVHPGAGNTSGTLLNALLHRDSTFFNIPRAGIVHRLDKDT 143

Query: 58  SGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAR 117
           +G++++  ++ +   L  Q +  ++ + Y AIV G ++    +   ++    K       
Sbjct: 144 TGLMVIAKNNLSYMALIDQIKCKKVIREYQAIVYGKVISGGTIVKSIIRNPIKRTTMIV- 202

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
            +K  + A+THYR L              T +  +++  +TGR HQ+R H+ ++  P++G
Sbjct: 203 -NKCGKRAITHYRILKRF-----------THHTHLKIILETGRTHQIRTHMLYINFPLVG 250

Query: 178 DSKHGDLRQNRSGAEHFGL------QRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
           D  +G+  +         L       R  LHAS+L L HP T   +  ++ L    +  +
Sbjct: 251 DKTYGNKFKFYKNISLTLLEQVKKFPRQALHASRLCLYHPVTKHLMEWNSTLPRDMLNLI 310

Query: 232 SQFG 235
           +   
Sbjct: 311 ALLN 314


>UniRef50_Q39Z12 Pseudouridine synthase n=3 Tax=Proteobacteria RepID=Q39Z12_GEOMG
          Length = 270

 Score =  281 bits (720), Expect = 2e-74,   Method: Composition-based stats.
 Identities = 123/242 (50%), Positives = 160/242 (66%), Gaps = 1/242 (0%)

Query: 3   EILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLL 62
           EILY+DE LVAV+KP G LVHRS +DR E    +Q VRD +G+ V+  HRLD+PTSGVLL
Sbjct: 2   EILYRDEHLVAVHKPLGLLVHRSPIDRHETRFALQEVRDLLGRRVYPVHRLDKPTSGVLL 61

Query: 63  MGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIAD-KFAREDKG 121
             L     R L   F    + K Y A+VRG + EE V+D+PL EE D+    +    ++ 
Sbjct: 62  FALDPAFARGLVGAFASGSVTKTYLAVVRGTMPEEGVIDHPLAEEPDRFEQGRGNAGERA 121

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
           PQ AVT YR LA VE+PVA GRYPT+RY LV L P+TGR+HQLRRHL HL HPI+GD+K+
Sbjct: 122 PQSAVTGYRRLADVELPVAVGRYPTSRYSLVSLSPRTGRRHQLRRHLKHLFHPIVGDTKY 181

Query: 182 GDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWRGLLP 241
           G+ R NR   E     R++LHA +L++ HP TG PLT+ A ++  +   L++FGW   +P
Sbjct: 182 GEGRHNRFFREELLTVRMLLHAVELTVPHPATGAPLTVCAPVEGAFAALLARFGWLSAVP 241

Query: 242 EN 243
             
Sbjct: 242 SR 243


>UniRef50_A3DDK9 Pseudouridine synthase, RluA family n=3 Tax=Clostridium
           thermocellum RepID=A3DDK9_CLOTH
          Length = 318

 Score =  281 bits (720), Expect = 2e-74,   Method: Composition-based stats.
 Identities = 64/252 (25%), Positives = 103/252 (40%), Gaps = 31/252 (12%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVM---QTVRDQIGQHVFTAHRLDRPTS 58
           ++I+Y+DE+L+A+NK  G +VH +       +         +  I + +    RLDR TS
Sbjct: 79  IDIIYEDEFLIALNKQPGIVVHPTCSHPGGTLANAVAFHLQKKGIVKKIRPVIRLDRDTS 138

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADKFAR 117
           G+++   +      L +Q       K Y  IV   L  +   +D P+  +   I  +   
Sbjct: 139 GIIIFAKNPYCQEFLIRQMNDKTFIKEYIGIVHKVLENDNGTIDLPIARKPGSIMLRHIS 198

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
            D    PAVTHY  L  +               LV+   +TGR HQ+R H   + HP++G
Sbjct: 199 PD--GDPAVTHYTVLERL-----------NGATLVKFRLETGRTHQIRVHCQAIGHPLLG 245

Query: 178 DSKH----------GDLRQ----NRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGL 223
           D+ +          G+       N        + R  LH+ +    HPFT + L I A +
Sbjct: 246 DTLYPFEDTPYSLSGNNPHITQANTPSITSGIITRQALHSQRAVFLHPFTKKILEITAPI 305

Query: 224 DDTWMQALSQFG 235
            +    AL    
Sbjct: 306 PEDMKSALEILR 317


>UniRef50_C0QPR5 Pseudouridine synthase n=4 Tax=Hydrogenothermaceae
           RepID=C0QPR5_PERMH
          Length = 319

 Score =  281 bits (719), Expect = 2e-74,   Method: Composition-based stats.
 Identities = 58/245 (23%), Positives = 105/245 (42%), Gaps = 22/245 (8%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVR------DQIGQHVFTAHRLDR 55
           ++IL++DE +  V KP+G +VH S       +V                +     HRLD+
Sbjct: 85  VDILFEDEDIAVVYKPAGMVVHPSPGHTSGTLVNALLYHFRNISEYGGKERAGIVHRLDK 144

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADK 114
            T+G++++  S  A + L +QF++  + KRY A+V G +  +   +D P+   +     K
Sbjct: 145 DTAGLMIIAKSEFAHKELQKQFQERTVDKRYIAVVTGIVQNDHGFIDLPIGRSIYNR-KK 203

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
              E    + A+T Y             R       +V+++  TGR HQ+R H + + HP
Sbjct: 204 MGTEATNLRDALTEYWV---------KNRSEKENLTVVDIKLHTGRTHQIRVHFSAIGHP 254

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRL----MLHASQLSLTHPFTGEPLTIH-AGLDDTWMQ 229
           +  D  +G  +      +   +        L A +++  HP TGE + I    L +   +
Sbjct: 255 LFNDKVYGFKKSQLRSEKMRSISDQTLYHALLAYRIAFDHPRTGEKIDITLQKLPEHISK 314

Query: 230 ALSQF 234
            +   
Sbjct: 315 VIEAI 319


>UniRef50_Q1Q689 Similar to ribosomal large subunit pseudouridine synthase D n=1
           Tax=Candidatus Kuenenia stuttgartiensis
           RepID=Q1Q689_9BACT
          Length = 335

 Score =  281 bits (719), Expect = 2e-74,   Method: Composition-based stats.
 Identities = 63/255 (24%), Positives = 106/255 (41%), Gaps = 28/255 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ------HVFTAHRLDR 55
           L I+Y+D++L+ +NKP   +VH +       +V   T   Q              HRLDR
Sbjct: 91  LNIIYEDDYLMLINKPYDMVVHPAGGHPSGTLVNAVTFYCQNLSQINGPLKAGIVHRLDR 150

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADK 114
            TSGV+L+  S      +A QFE+  ++K Y A+V G +  +   ++ P+          
Sbjct: 151 DTSGVMLVIKSDAVHSHIAMQFEKRLVKKEYFAVVEGEVAFDSNEINMPIGRHRVDRQKM 210

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
             R D   + A + Y  +                Y LV++ PKTGR HQ+R H+  + HP
Sbjct: 211 AVRRD-TGKNATSVYEVIERFR-----------GYTLVKIMPKTGRTHQIRVHMQAIGHP 258

Query: 175 IIGDSKHGDL---------RQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDD 225
           ++ D  +             + R+  E   ++R  LHA ++   HP   + +     + +
Sbjct: 259 VVADEMYSKYNACFRSDLLGKERAPDEGSIIERQALHAHRIEFFHPILNKQMAFQVDMAE 318

Query: 226 TWMQALSQFGWRGLL 240
                +S       L
Sbjct: 319 DISFLVSALRELRPL 333


>UniRef50_A6NQQ9 Pseudouridine synthase n=1 Tax=Bacteroides capillosus ATCC 29799
           RepID=A6NQQ9_9BACE
          Length = 300

 Score =  280 bits (718), Expect = 3e-74,   Method: Composition-based stats.
 Identities = 75/234 (32%), Positives = 107/234 (45%), Gaps = 24/234 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVM---QTVRDQIGQHVFTAHRLDRPTS 58
           L+I+YQD+ ++ +NK  G  VH       + +         +  I       HRLDR TS
Sbjct: 84  LDIVYQDQDVLVLNKAPGVAVHPGPGHYSDTIGNFLMDYYRKQGILADFHPVHRLDRGTS 143

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADKFAR 117
           G+LL+ L   A  +L +Q      ++ Y A+  G       V+D P+      +  +  R
Sbjct: 144 GLLLVALHGHAQEVLKEQLHSPSFRRVYLAVCEGAPNPPSGVIDAPIGRLEGSVLARTVR 203

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
            D   Q AVTHYR L TV               LV LE +TGR HQ+R H+AHL HP+ G
Sbjct: 204 PD--GQRAVTHYRTLRTV-----------NDRALVRLELETGRTHQIRVHMAHLGHPLTG 250

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
           D  +G         +   + R  LHA++LS THP TG+ +   A L       +
Sbjct: 251 DFLYG-------TEDQSLIPRPALHAAELSFTHPITGKTMAFTAPLPQDMAALV 297


>UniRef50_A8MF48 Pseudouridine synthase n=12 Tax=Clostridiaceae RepID=A8MF48_ALKOO
          Length = 305

 Score =  280 bits (717), Expect = 4e-74,   Method: Composition-based stats.
 Identities = 59/234 (25%), Positives = 105/234 (44%), Gaps = 24/234 (10%)

Query: 5   LYQDEWLVAVNKPSGWLVHRSWLDRDEKVVV---MQTVRDQIGQHVFTAHRLDRPTSGVL 61
           +Y+D  L+ VNK  G + H +    D  +     +      I   V   +RLD  TSG+L
Sbjct: 89  VYEDVDLILVNKEPGIVTHPTKSHPDWTIANGAALYLKSKGIDCKVRFVNRLDMDTSGLL 148

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADKFAREDK 120
           ++  ++ A  +L++Q ++ +I+K+Y A V G + E E  ++ P+         +    D+
Sbjct: 149 IIAKNAYAHHVLSEQMQEDRIEKKYIAFVWGVIKEDEGRIEAPIYRTTMDSIKRVV--DE 206

Query: 121 GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSK 180
             Q ++T ++ L   +              +VE++  TGR HQ+R H+ HL HP+IGD+ 
Sbjct: 207 RGQESITEFKVLERYK-----------NATMVEVKLLTGRTHQIRVHMEHLGHPLIGDTL 255

Query: 181 HGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           +G         +   + R  LHA  L    P     + + A L    +    + 
Sbjct: 256 YGK-------EDAELIDRQALHAEYLRFWQPRFKRAIEVKADLPADLLSLRDKL 302


>UniRef50_O31613 Uncharacterized RNA pseudouridine synthase yjbO n=53
           Tax=Bacillaceae RepID=YJBO_BACSU
          Length = 283

 Score =  280 bits (717), Expect = 4e-74,   Method: Composition-based stats.
 Identities = 65/235 (27%), Positives = 103/235 (43%), Gaps = 25/235 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVM---QTVRDQIGQHVFTAHRLDRPTS 58
           L+ILY+DE ++ +NK        S       +            +   V    RLDR TS
Sbjct: 66  LDILYEDEHVLVINKQPYVSSIPSREHPSGSIANGIIDHYQTTGVRATVHLVTRLDRDTS 125

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADKFAR 117
           G++L+     A  +L+   +   +++RY A+V G + + E  +D P+    D I ++   
Sbjct: 126 GIMLVAKHRFAHSILSSAQKNGLVKRRYAAVVHGRMAQMEGTVDAPIGRHPDSIIERTVT 185

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
            D   Q AVTH+                      V L+ +TGR HQ+R H+++L HP+ G
Sbjct: 186 PD--GQKAVTHFYV-----------TCANDDMTSVALQLETGRTHQIRVHMSYLGHPLCG 232

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALS 232
           D+ +G  RQ         + R  LH+  LS  HP T E +  HA L     + + 
Sbjct: 233 DTLYGGTRQE--------IGRQALHSEHLSFIHPLTQENMRFHAPLPQDMSKLIK 279


>UniRef50_B4U613 Pseudouridine synthase, RluA family n=1 Tax=Hydrogenobaculum sp.
           Y04AAS1 RepID=B4U613_HYDS0
          Length = 308

 Score =  280 bits (717), Expect = 4e-74,   Method: Composition-based stats.
 Identities = 58/242 (23%), Positives = 104/242 (42%), Gaps = 21/242 (8%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG------QHVFTAHRLDR 55
           ++ILY+D  L  V KPSG   H      +  +V     +          +     HRLDR
Sbjct: 79  IDILYEDNDLAVVVKPSGMPSHTGPGHDENTLVNALLAKFGDLSVIGGVERPGIVHRLDR 138

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADK 114
            T G++++  +  + + L+  F+  ++ K Y AIV G    +E  ++  +          
Sbjct: 139 YTHGLMVIAKNDVSHQKLSLMFKNKEVDKHYKAIVYGISRFKEQTIETFIRRHPTNRLKF 198

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
               +   + A+T Y           +   P     L++++  TGR HQ+R H++++ HP
Sbjct: 199 EVANE--GKLAITKY-----------SLEKPLKNASLLDIKIYTGRTHQIRVHMSYIGHP 245

Query: 175 IIGDSKHG-DLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           I+GD+ +G          EH   +R +L A +LS  HP + +P+     + D +   L  
Sbjct: 246 IVGDTLYGYKHSYFDKTLEHMIGKRFLLVAYKLSFLHPKSQKPMEFEIDMPDYFKNVLKY 305

Query: 234 FG 235
             
Sbjct: 306 LE 307


>UniRef50_C1CWT3 Pseudouridine synthase n=1 Tax=Deinococcus deserti VCD115
           RepID=C1CWT3_DEIDV
          Length = 321

 Score =  280 bits (717), Expect = 4e-74,   Method: Composition-based stats.
 Identities = 75/254 (29%), Positives = 113/254 (44%), Gaps = 29/254 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVR----------DQIGQHVFTAH 51
           L+++Y+D++L+AVNKP G + H +       +V     R           + G      H
Sbjct: 77  LDVIYEDDYLIAVNKPPGMVTHPAPGVLSGTLVNALLGRMPLPEQPDYDSEAGYRPGIVH 136

Query: 52  RLDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEA--VLDYPLVEELD 109
           RLD+ TSGV+++  +  A   LA  F+  + +K Y AI  G    +    ++ P+     
Sbjct: 137 RLDKDTSGVIVVAKTVGAHARLAAAFKDRETRKTYLAIAAGQWRADGPARVEAPIGRHPV 196

Query: 110 KIADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLA 169
           +           P+ A T +  LA      A          LV  +P+TGR HQ+R HLA
Sbjct: 197 QRQRMTV-GGANPREAQTLFTPLA------AHPDGHGRTLALVRAQPRTGRTHQIRVHLA 249

Query: 170 HLRHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQ 229
           HL  PI+GD+ +G   +           R  LHA  LS+ HP TG  L +HA   D  + 
Sbjct: 250 HLGSPILGDAVYGRSSETML--------RHALHAHFLSVPHPGTGRLLHLHAPAPDDMLN 301

Query: 230 ALSQFGWRGLLPEN 243
           A    G  G +P +
Sbjct: 302 AWIALG--GAMPSD 313


>UniRef50_B8CWB7 Pseudouridine synthase n=1 Tax=Halothermothrix orenii H 168
           RepID=B8CWB7_HALOH
          Length = 310

 Score =  279 bits (715), Expect = 7e-74,   Method: Composition-based stats.
 Identities = 65/237 (27%), Positives = 119/237 (50%), Gaps = 24/237 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVV--MQTVRDQIGQH-VFTAHRLDRPTS 58
           L+I+Y+D  L+ +NKP+  LVH + +++   +V   +  +R+Q   + V   HRLDR T+
Sbjct: 93  LDIIYEDRHLLVINKPANMLVHPTPVEKSNTIVNGVLYHMRNQGNYNLVRPIHRLDRNTT 152

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADKFAR 117
           G+LL+  +  A   +  QF+ + I + Y A V G +  ++  ++ P+ +  D +  +   
Sbjct: 153 GLLLIAKNQYAHNYITHQFQNNNIHREYLAFVHGNVEFKKESINAPIGKTRDSLIKRKVD 212

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
                + AVTH + +            P     L+ ++ +TGR HQ+R HL+HL HP++G
Sbjct: 213 HTL-GKRAVTHIKVVK-----------PGGLISLIRVKLETGRTHQIRVHLSHLGHPLLG 260

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           D+ +G         E   ++R  LH+ +++   PF  + +T  A L     +   Q 
Sbjct: 261 DTLYGG--------EDILIKRPALHSYKVTCCLPFKHKEVTFKAPLPVDMEKLKKQL 309


>UniRef50_Q6MGX8 Pseudouridine synthase n=1 Tax=Bdellovibrio bacteriovorus
           RepID=Q6MGX8_BDEBA
          Length = 319

 Score =  279 bits (715), Expect = 7e-74,   Method: Composition-based stats.
 Identities = 60/261 (22%), Positives = 109/261 (41%), Gaps = 37/261 (14%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVR------DQIGQHVFTAHRLDR 55
           L++L++DE L+ +NKP+G +VH +     + +V                +     HRLD+
Sbjct: 69  LDVLFEDEDLIVINKPAGLVVHPAAGHAHDTLVNALIHHTDDLSMKFGEERPGIVHRLDK 128

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADK 114
            TSG++++  + +A   L  QF++    + Y+A+  G        +   L          
Sbjct: 129 ETSGIIVIAKNDKAHESLTSQFKERSTHRIYYAVCLGTARTLSGSVRSFLARHPVDRKRY 188

Query: 115 FAREDKGPQP-------------AVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRK 161
            +      +P             AVTH+  L              +    ++L+ +TGR 
Sbjct: 189 ASVLGDDRKPLTDPNDDPGLGKWAVTHFEVLQR-----------KSGMSYLKLKLETGRT 237

Query: 162 HQLRRHLAHLRHPIIGDSKHGDLRQNRSGAEH------FGLQRLMLHASQLSLTHPFTGE 215
           HQ+R H++    PI GD+ +G  R+ +S            L R +LHA++L  THP T E
Sbjct: 238 HQIRVHMSESGLPIAGDTLYGADRKIKSIEARATQEDLRTLPRFLLHAAELGFTHPRTKE 297

Query: 216 PLTIHAGLDDTWMQALSQFGW 236
            +       +  +  + ++G 
Sbjct: 298 RMFFTKDWPEDVLVLIKKWGL 318


>UniRef50_D1AV01 Pseudouridine synthase n=2 Tax=Bacteria RepID=D1AV01_STRM9
          Length = 297

 Score =  279 bits (714), Expect = 8e-74,   Method: Composition-based stats.
 Identities = 59/240 (24%), Positives = 115/240 (47%), Gaps = 29/240 (12%)

Query: 5   LYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ------HVFTAHRLDRPTS 58
           +Y+D++L  +NK +G +VH S    ++ +V     + +              HRLD+ TS
Sbjct: 78  VYEDKYLAIINKYAGMVVHPSKGHEEDTLVNAIMYKIKDLSGINGDLRPGIVHRLDKNTS 137

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADKFAR 117
           G++++    +    L++ F+  +I+K Y+AIV+G +  +   ++  +    +        
Sbjct: 138 GLIIIAKDDKTHFKLSEMFKNKEIKKIYYAIVKGKVNKKSGRIETMIGRNPNDRKKMAVV 197

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
           +    + A+T++  + + E           ++ L++++ +TGR HQ+R HL+H   PI+G
Sbjct: 198 D--NGKLAITNFEVIDSNE-----------KFSLLKVDLETGRTHQIRVHLSHFFFPILG 244

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWR 237
           DS +G   +           R MLHA  L+  HP T E + +       +++ALS    R
Sbjct: 245 DSVYGRKDEY---------DRQMLHAYMLNFIHPITLEKIDVIGNFHSDFLRALSNTKLR 295


>UniRef50_C6LL16 Pseudouridine synthase n=3 Tax=Clostridiales RepID=C6LL16_9FIRM
          Length = 313

 Score =  278 bits (712), Expect = 1e-73,   Method: Composition-based stats.
 Identities = 64/234 (27%), Positives = 106/234 (45%), Gaps = 25/234 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFT---AHRLDRPTS 58
           L+I+Y+DE L+ ++KP+   VH S  + D  +        +     F      RLDR T+
Sbjct: 85  LDIVYEDEDLLVIDKPADMPVHPSIHNFDNTLANGLAYYYESRGEAFVYRCITRLDRDTT 144

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           G+LL+  +  +G  LA+  ++ +I + Y AIV G    E  +D P+      + ++    
Sbjct: 145 GLLLVAKNMLSGAFLAEMGKRREIHREYLAIVTGKTEAEGTVDAPIARVEGSVLERCVDF 204

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
            +  + AVTHYR L                Y LV L+ +TGR HQ+R H+ ++ HP+ GD
Sbjct: 205 QR-GERAVTHYRTLEY-----------RDGYSLVRLKLETGRTHQIRVHMKYIGHPLTGD 252

Query: 179 SKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALS 232
             +          ++  +    LH+  L+  HP TGE +   +     W     
Sbjct: 253 FLY--------NPDYRLMDHQALHSHYLAFRHPITGERMEFTSQPP--WQGLWE 296


>UniRef50_C0ZCK6 Pseudouridine synthase n=1 Tax=Brevibacillus brevis NBRC 100599
           RepID=C0ZCK6_BREBN
          Length = 302

 Score =  278 bits (712), Expect = 1e-73,   Method: Composition-based stats.
 Identities = 68/237 (28%), Positives = 107/237 (45%), Gaps = 25/237 (10%)

Query: 3   EILYQDEWLVAVNKPSGWLVHRSWLDRDEKV---VVMQTVRDQIGQHVFTAHRLDRPTSG 59
           EILY+D+ L+ VNKP G L+H +       +   V     R  +   V   HRLD+ TSG
Sbjct: 87  EILYEDDHLLIVNKPVGLLLHPTERYHHVTLDHLVSGHFFRTGLEAKVRHVHRLDQDTSG 146

Query: 60  VLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADKFARE 118
           V+L      A  LL +   +  I++ Y A V G + +E   ++ P+ ++ +    +    
Sbjct: 147 VVLYAKHPWASALLDEMLRERTIKRTYVAYVSGQMPKERGKINEPIGKDRNHGTRRRVT- 205

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
                PA+THY+                     VE + +TGR HQ+R H +H+ HP++GD
Sbjct: 206 -PNGDPAITHYQVKERF-----------QTATKVECQLETGRTHQIRVHFSHIGHPLLGD 253

Query: 179 SKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFG 235
             +G  R+         ++R  LHA+ L   HPF GE + + A L         +  
Sbjct: 254 ELYGGKRE--------LIKRQALHAAVLKFEHPFGGEVIEVTAPLPLDLFHLEKKLR 302


>UniRef50_B3DV48 Pseudouridine synthase n=1 Tax=Methylacidiphilum infernorum V4
           RepID=B3DV48_METI4
          Length = 325

 Score =  277 bits (711), Expect = 2e-73,   Method: Composition-based stats.
 Identities = 65/245 (26%), Positives = 102/245 (41%), Gaps = 26/245 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ------HVFTAHRLDR 55
           LEILY+DE ++ VNK  G +VH S       +V                      HRLD+
Sbjct: 91  LEILYEDEEILIVNKQRGMVVHPSCGHWSGTLVNSLLFHYGESLPGSSLLRPGIVHRLDK 150

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAV-LDYPLVEELDKIADK 114
            TSGV+++  +  + + L  QF Q  +QK Y  + +          +  +          
Sbjct: 151 DTSGVMVIAKTERSLKSLLLQFSQRTVQKVYLCLCKNRFPYLRYSFEANIHRHASDRKKM 210

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
                K  + A T +  L           + +++   ++ EP +GR HQ+R HL+HL  P
Sbjct: 211 AVHRLK-GKTAETRFTLL-----------FASSQASFLKCEPVSGRTHQIRVHLSHLGFP 258

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           IIGD  +G   +            L+LHA  L + HP +G+ +   A L   + +AL  F
Sbjct: 259 IIGDPLYGKGVRKYPFP-------LLLHAYALKIEHPRSGKKIEFMAPLPQDFKEALDFF 311

Query: 235 GWRGL 239
             R  
Sbjct: 312 YGRNF 316


>UniRef50_B7HGW1 Pseudouridine synthase n=52 Tax=Bacillales RepID=B7HGW1_BACC4
          Length = 297

 Score =  277 bits (711), Expect = 2e-73,   Method: Composition-based stats.
 Identities = 65/236 (27%), Positives = 109/236 (46%), Gaps = 25/236 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRD---QIGQHVFTAHRLDRPTS 58
           L I+Y+D+ ++ +NK +      S       V            +   V    RLDR TS
Sbjct: 82  LCIIYEDDAVLIINKEANMSTIPSREHPAGSVANALLSHYDKQHLASTVHIVTRLDRDTS 141

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGW-LMEEAVLDYPLVEELDKIADKFAR 117
           G++L+  +     LL++Q +Q  +++ Y AIV G  +  E ++D P+  + D I ++   
Sbjct: 142 GLMLIAKNRFVHHLLSKQHQQKAVKRTYEAIVHGKIVEREGMIDAPIGRKSDSIIERTVC 201

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
           ED   Q AVTH++ + +                 V LE +TGR HQ+R H+AH+ HP++G
Sbjct: 202 ED--GQRAVTHFKVIDSTYHK-----------THVALELETGRTHQIRVHMAHVGHPLLG 248

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           DS +G  R          ++R  LH+  L+  HP   + ++    L     + L  
Sbjct: 249 DSLYGGRRDE--------MKRQALHSKSLTFYHPILEKEMSFTIKLPSDMQEVLRH 296


>UniRef50_Q8ZQ16 Ribosomal large subunit pseudouridine synthase C n=110
           Tax=Gammaproteobacteria RepID=RLUC_SALTY
          Length = 319

 Score =  277 bits (711), Expect = 2e-73,   Method: Composition-based stats.
 Identities = 74/234 (31%), Positives = 114/234 (48%), Gaps = 14/234 (5%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLM 63
           ILY+D+ ++ +NKPSG  VH         +  ++ +R    + +   HRLDR TSGVLL+
Sbjct: 95  ILYEDDHILVLNKPSGTAVHGGSGLSFGVIEGLRALR-PEARFLELVHRLDRDTSGVLLV 153

Query: 64  GLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADKFAREDKGP 122
                A R L +Q  +  +QK Y A+VRG        +  PL++ + +  ++  R  +  
Sbjct: 154 AKKRSALRSLHEQLREKGMQKDYLALVRGQWQSHVKTVQAPLLKNILQSGERIVRVSQEG 213

Query: 123 QPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHG 182
           +P+ T ++                    LV   P TGR HQ+R H  +  HPI  D ++G
Sbjct: 214 KPSETRFKVEERYAF-----------ATLVRCSPVTGRTHQIRVHTQYAGHPIAFDDRYG 262

Query: 183 DLRQNRSGAEH-FGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFG 235
           D   ++   E   GL+RL LHA+ L  THP TGE + I A +D+   + L    
Sbjct: 263 DREFDQQLTEAGTGLKRLFLHAAALKFTHPGTGEVMRIEAPMDNALKRCLQVLR 316


>UniRef50_A1HR26 Pseudouridine synthase, RluA family n=1 Tax=Thermosinus
           carboxydivorans Nor1 RepID=A1HR26_9FIRM
          Length = 301

 Score =  277 bits (710), Expect = 2e-73,   Method: Composition-based stats.
 Identities = 71/240 (29%), Positives = 110/240 (45%), Gaps = 26/240 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV---VMQTVRDQIGQHVFTAHRLDRPTS 58
           L I+Y+D++L+ VNKP+G LVH +    +  +    +               HRLDR TS
Sbjct: 75  LHIVYEDDFLLIVNKPAGLLVHPTSDPTEPTLAHGILYYLHSKGALGAFHPIHRLDRNTS 134

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADKFAR 117
           G++ +         L+    +  +++ Y A+V G        +D P+    + I  +  R
Sbjct: 135 GLVAIAKHPHIQHALSGGGAKG-LKRLYLAVVTGIPSSLMGRIDAPIGRHPNSIIKRVVR 193

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
            D   QPA+T YR L+T  M             LVELE  TGR HQ+R HL+H+ HP++G
Sbjct: 194 SD--GQPAITLYRVLSTFSM-----------ASLVELELLTGRTHQIRVHLSHIGHPLLG 240

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWR 237
           D  +G             ++R  LHA+ LS  HP T + LT+ + L       +     +
Sbjct: 241 DDLYGG--------ATDLIRRQALHAASLSFRHPATDKVLTLTSPLPPDLADLIQLLRQK 292


>UniRef50_B8FTI5 Pseudouridine synthase n=2 Tax=Desulfitobacterium hafniense
           RepID=B8FTI5_DESHD
          Length = 302

 Score =  277 bits (710), Expect = 2e-73,   Method: Composition-based stats.
 Identities = 71/237 (29%), Positives = 108/237 (45%), Gaps = 25/237 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKV---VVMQTVRDQIGQHVFTAHRLDRPTS 58
           LEILY+D++ +A+NKP+G +VH +       +   VV   +     +     HR+DR TS
Sbjct: 83  LEILYEDDYFIAINKPAGQVVHPTPRYPRGTIGNAVVGYWLAKGEARPFRPIHRIDRNTS 142

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRG-WLMEEAVLDYPLVEELDKIADKFAR 117
           GV+++G +  A + +A Q    +I K Y  IV G  + ++  +  P+    D    +   
Sbjct: 143 GVVVIGKNQFAHQQMAWQHAHGRIHKCYRGIVEGQVMEDQGTIKAPIALAPDSFIQRQI- 201

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
                 PAVT Y+ L                  L+E   +TGR HQ+R H  HL HP++G
Sbjct: 202 -SPEGSPAVTLYKVLERY-----------QDASLLEFILETGRTHQIRVHCQHLGHPLLG 249

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           D  +G             + R  LH+S     HP TGE  TI A L +   + L + 
Sbjct: 250 DDLYGGN--------LARINRQALHSSIYEFNHPLTGELTTIQAPLPEDLQRLLREL 298


>UniRef50_C7MN62 Pseudouridine synthase n=8 Tax=Coriobacteriaceae RepID=C7MN62_CRYCD
          Length = 347

 Score =  277 bits (710), Expect = 2e-73,   Method: Composition-based stats.
 Identities = 59/247 (23%), Positives = 98/247 (39%), Gaps = 18/247 (7%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTV--------RDQIGQHVFTAHRL 53
           L++ ++D W++A++K +G  VH +       +V               Q        HRL
Sbjct: 82  LDVRFEDRWMMAISKQAGLCVHPAPGHEGGTLVNALIYAYGRDSLAHVQGDDRPGIVHRL 141

Query: 54  DRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIA 112
           D  TSG+++       G  L      H++ +RY  +V G +  +   +D P+    D   
Sbjct: 142 DMDTSGLMMCAKDDTCGMALQDLVRDHKVDRRYLTLVHGNIAFDTGQIDEPIGRVGDDRL 201

Query: 113 DKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLR 172
                     + A+T +  L   E            Y L+E    TGR HQ+R H+  + 
Sbjct: 202 RMKISYRPTARNALTTFTVLERFE-----AGRADNGYTLLECRLYTGRTHQIRVHMEFIG 256

Query: 173 HPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALS 232
           H  +GD  +    +  +   +  L R  LH+  LS  HP TG+ + +  GL      AL 
Sbjct: 257 HCCVGDPLY----RWGNEQVNLELSRQFLHSYSLSFNHPMTGDDIALVDGLPPDLFGALR 312

Query: 233 QFGWRGL 239
               R +
Sbjct: 313 SLEDRSM 319


>UniRef50_Q0F3G2 Possible pseudouridine synthase n=1 Tax=Mariprofundus ferrooxydans
           PV-1 RepID=Q0F3G2_9PROT
          Length = 325

 Score =  277 bits (709), Expect = 4e-73,   Method: Composition-based stats.
 Identities = 60/246 (24%), Positives = 100/246 (40%), Gaps = 26/246 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ------HVFTAHRLDR 55
           L+IL++DE L+ +NKP+G +VH S       +V       +              HRLD+
Sbjct: 88  LDILFEDEHLIVLNKPAGIVVHPSHGHDHGTLVHALLHHCKTLPGINGVERPGIVHRLDK 147

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADK 114
            TSG L++  S    + L++ F +H + ++Y A  RG        ++ P+     +    
Sbjct: 148 DTSGSLVIAKSEVVHQRLSEMFAEHNLNRQYIAWCRGVPSWRVKCIELPIGRHPHQRQKM 207

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
              +    + ++T            A   +    +  + L   TGR HQ+R H+AH   P
Sbjct: 208 AVTDS--GRESITD-----------AAVEHIFGPFSQMRLTLHTGRTHQIRVHMAHENLP 254

Query: 175 IIGDSKH------GDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWM 228
           ++GD  +      G      +      L R  LHA  L   HP +GEP++  A L +   
Sbjct: 255 VLGDPVYARSYHPGREIPEPARHAIATLSRQALHAELLEFDHPISGEPMSFRAPLPEDLT 314

Query: 229 QALSQF 234
                 
Sbjct: 315 ILHDAL 320


>UniRef50_A5ZUU7 Pseudouridine synthase n=1 Tax=Ruminococcus obeum ATCC 29174
           RepID=A5ZUU7_9FIRM
          Length = 293

 Score =  276 bits (708), Expect = 4e-73,   Method: Composition-based stats.
 Identities = 59/233 (25%), Positives = 104/233 (44%), Gaps = 23/233 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKV---VVMQTVRDQIGQHVFTAHRLDRPTS 58
           + +LY+DE ++ VNKP+   VH S  +    +   V                +RLDR TS
Sbjct: 81  IPVLYEDEDILVVNKPADMPVHPSLGNYTNTLANGVAAYLETKGESCPFRCINRLDRDTS 140

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           G L++  ++ +  +L+ Q    QI + Y A+V G   +   +  P+    D + ++    
Sbjct: 141 GALILAKNALSAAILSVQMRNRQISRTYLAVVEGIPRQSGTISAPISRAADSVIERRIDF 200

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
           +   + A+THY+ L                + L+E+  +TGR HQ+R H+ ++ HP+  D
Sbjct: 201 E-NGESAITHYQLLE-----------VKNNHSLLEIHLETGRTHQIRVHMGYIGHPLPAD 248

Query: 179 SKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
             +  +            +R  LH+ QL   HP TG P+ + A + +    A 
Sbjct: 249 YLYNPVYDT--------FKRQPLHSLQLKFCHPITGTPMCLMAPVPEDMSNAF 293


>UniRef50_C9M7B4 Pseudouridine synthase n=1 Tax=Jonquetella anthropi E3_33 E1
           RepID=C9M7B4_9BACT
          Length = 301

 Score =  276 bits (706), Expect = 7e-73,   Method: Composition-based stats.
 Identities = 68/238 (28%), Positives = 101/238 (42%), Gaps = 22/238 (9%)

Query: 5   LYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTV----RDQIGQHVFTAHRLDRPTSGV 60
           +Y D+WL  V K +G  VH     +D  +V             G      HRLD  TSG+
Sbjct: 81  VYADDWLAVVEKLAGIAVHPGAGRKDGTLVNGLVKTFGPLPGAGLRPGIVHRLDIGTSGL 140

Query: 61  LLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGW-LMEEAVLDYPLVEELDKIADKFARED 119
           +++  + +A   L ++F Q +++K Y A+V GW    +  LD P+            R D
Sbjct: 141 MVVARTPQAYLFLQREFSQRRVEKTYLALVHGWIPASQGTLDGPIGRSRYDRLKMAVRAD 200

Query: 120 KGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDS 179
              + AVT YR L T                L     +TGR HQ+R H+A +   + GD 
Sbjct: 201 --GRRAVTRYRTLWT-----------RGSLSLTACRIETGRTHQIRVHMASIGCYLDGDR 247

Query: 180 KHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWR 237
            +G    +R    HF   R+ LHA +LS  HP  G  +   + L D  +  L +    
Sbjct: 248 LYGPKDVSR----HFLEGRVFLHAWRLSFHHPSDGRTMNFRSPLPDELIGVLKKIRSE 301


>UniRef50_C0MA80 Pseudouridine synthase n=6 Tax=Streptococcus RepID=C0MA80_STRE4
          Length = 300

 Score =  275 bits (704), Expect = 1e-72,   Method: Composition-based stats.
 Identities = 68/242 (28%), Positives = 103/242 (42%), Gaps = 26/242 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVV----MQTVRDQIGQHVFTAHRLDRPT 57
           L+I+Y+DE  + +NKP+G+    S +     +          +D   + V    RLDR T
Sbjct: 76  LDIVYEDEHFLILNKPAGYASIPSAIH-SNTIANFIKAYYIKQDYPNKQVHIVTRLDRDT 134

Query: 58  SGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRG--WLMEEAVLDYPLVEELDKIADKF 115
           SG++L      A   L +Q +Q  I KRY+A+V G   L ++  +  P+    D I  + 
Sbjct: 135 SGLMLFAKHGYAHARLDKQLQQRAINKRYYALVCGQERLPDQGEIIAPIGRTDDSIITRT 194

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
                  + A T Y+ +A                 LV++   TGR HQ+R H AHL  P+
Sbjct: 195 VT--PKGKYAKTSYKVIARYPE----------NVSLVDITLHTGRTHQIRVHFAHLGFPL 242

Query: 176 IGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFG 235
           +GD  +G            G+ R  LH   LS THPFT         L D +   +    
Sbjct: 243 LGDDLYGGR-------LDLGMTRQALHCHHLSFTHPFTESRSDHTICLTDDFESVIIDLQ 295

Query: 236 WR 237
            +
Sbjct: 296 KK 297


>UniRef50_Q14NK8 Probable pseudouridine synthase d protein n=1 Tax=Spiroplasma citri
           RepID=Q14NK8_SPICI
          Length = 306

 Score =  275 bits (704), Expect = 1e-72,   Method: Composition-based stats.
 Identities = 70/244 (28%), Positives = 113/244 (46%), Gaps = 25/244 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVR------DQIGQHVFTAHRLDR 55
           L ILY+D +L+ ++KP+  +VH +   +++ +V     R          Q     HR+DR
Sbjct: 81  LTILYEDSYLMVIDKPNNLVVHPAPGHQNDTLVNALLARGVQWSTASGEQRPGIVHRIDR 140

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRG-WLMEEAVLDYPLVEELDKIADK 114
            T+G L++  +      L QQ +  Q+Q+RY A+V G  +   A +D P+  + +    K
Sbjct: 141 QTTGTLIIAKNDVVHHQLQQQIQTKQLQRRYLALVHGQIIENRAKIDAPIGRDPNNR-KK 199

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
                K  + A+T+   +                Y  +E E ++GR HQ+R HL ++ HP
Sbjct: 200 MVVTAKNSKKALTNIVVIERF-----------NDYTYIECELESGRTHQIRAHLKYINHP 248

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           I+GD  +G +   +            LHA QL   HP T E LTI A L   + Q L+  
Sbjct: 249 IVGDPLYGTVADKKESF------GQYLHAYQLRFIHPVTKESLTITAALPQEFEQRLAIL 302

Query: 235 GWRG 238
             +G
Sbjct: 303 RAKG 306


>UniRef50_A8RHQ2 Pseudouridine synthase n=2 Tax=Clostridium RepID=A8RHQ2_9CLOT
          Length = 287

 Score =  275 bits (704), Expect = 1e-72,   Method: Composition-based stats.
 Identities = 64/233 (27%), Positives = 105/233 (45%), Gaps = 21/233 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHV---FTAHRLDRPTS 58
           L I+Y+DE ++ +NK +G  +H S    D  +    +               +RLDR T+
Sbjct: 69  LSIVYEDEDILVINKDAGVPIHPSQGHYDNTLANAVSWYFHEKGEAFTYRVINRLDRDTT 128

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           G+L++     +  +L++Q    +I++ Y AIV G   EE  +D P+        ++    
Sbjct: 129 GLLVLARHMLSACILSEQMTGRRIRREYRAIVLGHTPEEGTVDSPIARAEGSTIERRVDH 188

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
           +   + AVTH+R L   E              LV L  +TGR HQ+R H+  + HP+ GD
Sbjct: 189 E-TGERAVTHFRTLLYNEEK---------DLSLVSLSLETGRTHQIRVHMRSIGHPLPGD 238

Query: 179 SKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
             +          ++  + R  LH+  L   HP TG+ +   AGL +   Q L
Sbjct: 239 FLY--------CPDYRYIDRQPLHSYLLRFEHPITGKEMEFTAGLPEDMKQLL 283


>UniRef50_Q5QZ45 Pseudouridine synthase n=2 Tax=Gammaproteobacteria
           RepID=Q5QZ45_IDILO
          Length = 315

 Score =  275 bits (704), Expect = 1e-72,   Method: Composition-based stats.
 Identities = 77/232 (33%), Positives = 114/232 (49%), Gaps = 14/232 (6%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLM 63
           ILY+D+ L+ +NKPSG  VH     +   +  ++ +R +    +   HR+DR TSG+LL+
Sbjct: 94  ILYEDDALMLINKPSGVAVHGGSGLQFGLIEGLRALRPKEKS-LELVHRIDRDTSGLLLV 152

Query: 64  GLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAV-LDYPLVEELDKIADKFAREDKGP 122
                  R L +Q    ++ K+Y A+VRG   +    ++ PL +   K  ++  R D   
Sbjct: 153 AKKRSVLRSLHEQLRNKEMNKQYLALVRGQWQKRVRSVEAPLKKNTLKSGERIVRVDAEG 212

Query: 123 QPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHG 182
           + ++T +R     +              LVE  P TGR HQ+R H  H  HPI  D K+G
Sbjct: 213 KASLTRFRIQQRYKEG-----------TLVEASPVTGRTHQIRVHALHAGHPIAKDPKYG 261

Query: 183 DLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           D   + + +   GL RL LHA QL   HP TG+ +   A LDD   Q L Q 
Sbjct: 262 DTDFDNTMS-RLGLNRLFLHAWQLRFLHPVTGKEVAFEAPLDDNLQQTLKQL 312


>UniRef50_P59838 Ribosomal large subunit pseudouridine synthase D n=3
           Tax=Gammaproteobacteria RepID=RLUD_BLOFL
          Length = 321

 Score =  273 bits (700), Expect = 4e-72,   Method: Composition-based stats.
 Identities = 61/246 (24%), Positives = 102/246 (41%), Gaps = 26/246 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQ----IGQHVFTAHRLDRPT 57
           L I+Y+D  ++ +NK S  +VH         V+     R      I +      RLD+ T
Sbjct: 86  LNIIYEDNDILVINKASNMVVHPGIGHYQGTVLNALLYRYPSILKISKQAGIVQRLDKDT 145

Query: 58  SGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADKFA 116
           +G++++  +  A   L + F+  ++ K Y AIV G       V++ P+     K      
Sbjct: 146 TGLMIIAKTVSAYDNLLRSFKLRKVVKEYDAIVYGKFTSNAGVVNQPMRRHFAKRTFMSV 205

Query: 117 REDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPII 176
                 + AVT+Y  +   +            +  V +  KTGR HQ+R H+A++ HP++
Sbjct: 206 HY--TGKSAVTYYSVVEEFKA-----------HSRVRINLKTGRTHQIRVHMAYINHPLV 252

Query: 177 GDSKH-GDLRQNRSGAEH-------FGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWM 228
           GD K+ G+                     R  LHA  L L HP T   +  +A L    +
Sbjct: 253 GDQKYKGNFSVFDIKKMSDELNNYLLDFNRQALHACTLQLLHPITQVQMKWNAPLPQDIL 312

Query: 229 QALSQF 234
           Q ++  
Sbjct: 313 QLIAIL 318


>UniRef50_Q31IZ8 Pseudouridine synthase n=2 Tax=Proteobacteria RepID=Q31IZ8_THICR
          Length = 252

 Score =  273 bits (699), Expect = 5e-72,   Method: Composition-based stats.
 Identities = 114/237 (48%), Positives = 153/237 (64%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
            +ILYQD+ LVAV+KP+G LVHRS +DR E    +Q  RDQI Q V+  HRLD+ TSG+L
Sbjct: 10  FKILYQDDSLVAVHKPAGLLVHRSPIDRHETQFAVQMTRDQINQKVYPLHRLDKATSGLL 69

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKG 121
           L  L S   RL+ QQFE+H IQK Y AI RGW  E   +D+ L  +LDK+ D+ A+ +K 
Sbjct: 70  LFALDSNTARLMGQQFEEHTIQKHYLAICRGWTAEHGEIDHALKHKLDKLGDRHAQTNKP 129

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
           PQ A+T++  LAT ++    G++ + RY LV+L PKTGRKHQLRRHL H+ HPIIGD K+
Sbjct: 130 PQEALTNFERLATTDVMHKIGKFDSQRYSLVKLMPKTGRKHQLRRHLNHISHPIIGDVKY 189

Query: 182 GDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWRG 238
           GD   N       G  RL L A+ L+  HP T   +T++A L+ ++ +A     W+ 
Sbjct: 190 GDRHHNHFFNTWLGQHRLYLAATSLTFNHPQTNARMTLNAPLELSYQKATQHLNWQE 246


>UniRef50_Q5Z8P2 RNA pseudourine synthase 2, chloroplastic n=6 Tax=Magnoliophyta
           RepID=PUS2_ORYSJ
          Length = 445

 Score =  272 bits (698), Expect = 7e-72,   Method: Composition-based stats.
 Identities = 60/295 (20%), Positives = 106/295 (35%), Gaps = 71/295 (24%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ---------------- 45
           L+I+Y+D+ L+ VNKP+  +VH +  + +  +V       +I                  
Sbjct: 140 LDIVYEDDHLLVVNKPAHMVVHPAPGNANGTLVNAILHHCKISTFTCLARNSIDDECPDS 199

Query: 46  ---------------------------HVFTAHRLDRPTSGVLLMGLSSEAGRLLAQQFE 78
                                           HRLD+ TSG+L++     +   LA+QF+
Sbjct: 200 SDDDIDVFDIDQFTTGEVSSEVREALVRPGIVHRLDKGTSGLLVVAKDEHSHAQLAEQFK 259

Query: 79  QHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADKFAREDKG---PQPAVTHYRGLAT 134
            H I++ Y ++  G        ++ P+  + +      A    G    + A + Y+    
Sbjct: 260 LHTIRRVYISLTCGAPNPNSGRIEVPIARDPNNRIRMIATPGSGHRYARHAASRYKVREV 319

Query: 135 VEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHGDLRQNRSGAEHF 194
                           LVE   +TGR HQ+R H  +L  P++GD  +G  +         
Sbjct: 320 F---------AGGGSALVEWRLETGRTHQIRAHAKYLGIPLLGDETYGGTKSMALSLLRP 370

Query: 195 G---------------LQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
                           + R  LHA+ L   HP +G+ L       D + + L++ 
Sbjct: 371 RTPSRYHCDLSNMISKIDRPCLHAALLGFKHPHSGKILEFSCPPPDDFTEVLNEL 425


>UniRef50_Q9KQH0 Ribosomal large subunit pseudouridine synthase C n=59
           Tax=Proteobacteria RepID=RLUC_VIBCH
          Length = 315

 Score =  272 bits (696), Expect = 9e-72,   Method: Composition-based stats.
 Identities = 76/234 (32%), Positives = 119/234 (50%), Gaps = 17/234 (7%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLM 63
           I+Y+D+ L+ +NKPSG  VH         +  ++ +R Q  + +   HR+DR TSG+LL+
Sbjct: 97  IVYEDDHLLILNKPSGTAVHGGSGLHFGAIEALRALRPQ-ARFLELVHRIDRDTSGILLV 155

Query: 64  GLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADKFAREDKGP 122
                A R L  QF +  +QK Y+A+V G    E  V++ PL++          R +   
Sbjct: 156 AKKRSALRHLQAQFREKTVQKYYYALVMGHWDAECKVVNAPLLKNEVNS---IVRVNPNG 212

Query: 123 QPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHG 182
           +P+ T +R L                  LV+  P TGR HQ+R H  ++ HPI  D ++G
Sbjct: 213 KPSETRFRILEKF-----------AEATLVQASPVTGRTHQIRVHTQYMGHPIAWDDRYG 261

Query: 183 DLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGW 236
           D R + +    FG++RL LHA+ +   HP + + L IHA L+    QAL++   
Sbjct: 262 DRRFD-AYTAQFGIERLFLHAANIQFVHPASEKKLEIHAPLEAHLEQALTKMRQ 314


>UniRef50_Q3ECD0 RNA pseudourine synthase 2, chloroplastic n=4 Tax=Magnoliophyta
           RepID=PUS2_ARATH
          Length = 430

 Score =  272 bits (696), Expect = 1e-71,   Method: Composition-based stats.
 Identities = 59/292 (20%), Positives = 104/292 (35%), Gaps = 63/292 (21%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ---------------- 45
           L+I+Y+D+ ++ VNKP+  +VH +  +    +V        +                  
Sbjct: 148 LDIVYEDKHVLVVNKPAHMVVHPAPGNPTGTLVNGILHHCSLPCVDYSNSEEDDDSDEET 207

Query: 46  ------------------HVFTAHRLDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYH 87
                                  HRLD+ T+G+L++     +   LA+QF+ H I++ Y 
Sbjct: 208 FSDDEEMTTSPSSYAASVRPGIVHRLDKGTTGLLVVAKDEHSHAHLAEQFKLHTIERVYV 267

Query: 88  AIVRGWL-MEEAVLDYPLVEELDKIADKFA----REDKGPQPAVTHYRGLATVEMPVATG 142
           ++  G     +  ++ P+  +        A          + A + Y+ + T        
Sbjct: 268 SLTTGVPSPPQGRIEIPIGRDSSNRIRMAAIPGGVRGGRARHAASRYKVIETF------- 320

Query: 143 RYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHGDLR---------------QN 187
                   LVE   +TGR HQ+R H  ++  P++GD  +G  +               Q 
Sbjct: 321 --AGGGSALVEWRLETGRTHQIRAHAKYMGVPLLGDEVYGGTKSMALSLLQKRVSRSDQE 378

Query: 188 RSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWRGL 239
                   + R  LHA  L  THP TGE +           + +      GL
Sbjct: 379 EIIELISRMDRPCLHAIVLGFTHPCTGEIVKFSCPPPSDLAEIVGLLRRSGL 430


>UniRef50_D2RBY1 Pseudouridine synthase, RluA family n=1 Tax=Gardnerella vaginalis
           409-05 RepID=D2RBY1_GARVA
          Length = 321

 Score =  271 bits (695), Expect = 1e-71,   Method: Composition-based stats.
 Identities = 69/243 (28%), Positives = 113/243 (46%), Gaps = 24/243 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKV------VVMQTVRDQIGQ-HVFTAHRLD 54
           + I+Y D+ +V ++KP G   H +       V      V +        +       RLD
Sbjct: 92  IPIIYNDDDVVVIDKPVGVASHAAKGWSGPTVPECLEAVGIDIKTTLCDESRKGIVSRLD 151

Query: 55  RPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEA-VLDYPLVEELDKIAD 113
             TSG++L+  +  A  ++  QF +H ++K YHA+V+G L ++   +D P+         
Sbjct: 152 VGTSGLMLVCKTDFAYEVMKNQFAKHIVKKTYHALVQGDLAQDKATIDAPIGRAKVSDFR 211

Query: 114 KFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
                D   +PAVTH+  L              ++  LV +  +TGR HQ+R H + + H
Sbjct: 212 FTITSD--GKPAVTHWDVLERF-----------SQATLVSVNLETGRTHQIRVHFSSIGH 258

Query: 174 PIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           P++GDS +G    N   A+  GLQR  LH+ +L+ THP TG+ +T+ +        AL  
Sbjct: 259 PLVGDSMYG---ANPVLAQKLGLQRQWLHSMELTFTHPRTGKSVTVKSHYPLDLQHALEA 315

Query: 234 FGW 236
              
Sbjct: 316 MRA 318


>UniRef50_A6GP31 Pseudouridine synthase n=1 Tax=Limnobacter sp. MED105
           RepID=A6GP31_9BURK
          Length = 335

 Score =  271 bits (694), Expect = 2e-71,   Method: Composition-based stats.
 Identities = 69/236 (29%), Positives = 113/236 (47%), Gaps = 9/236 (3%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           L IL++DE L+ VNKPSG  VH         +  ++ +R +  Q +   HR+DR TSG+L
Sbjct: 104 LPILFEDEHLLVVNKPSGMAVHGGSGSSFGLIECIRALRAETHQDLELVHRIDRETSGIL 163

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADKFAREDK 120
           ++     A R L +Q      +K Y  +V G   E    +D PL++      +     D+
Sbjct: 164 IISKKRSALRKLQEQLRARSWKKYYKTLVLGHWPEALRQVDLPLLKTQSSEKEARVFVDE 223

Query: 121 GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSK 180
               A T ++ +   +   ++       + L++ +  TGR HQ+R H +  + PI GD +
Sbjct: 224 SGDKACTKFKVIQCYKSSYSS-------FTLIQAQILTGRTHQIRVHTSANKFPIAGDDR 276

Query: 181 HGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGW 236
           +G+   N+  A   GL+R+ LHA++L L HP T E + + A L       L     
Sbjct: 277 YGNFEMNKQLARQ-GLKRMFLHAARLQLVHPATNETIVLEAPLAPELDGFLKSLQA 331


>UniRef50_B6TXP4 RNA binding protein n=3 Tax=Poaceae RepID=B6TXP4_MAIZE
          Length = 439

 Score =  271 bits (694), Expect = 2e-71,   Method: Composition-based stats.
 Identities = 57/296 (19%), Positives = 104/296 (35%), Gaps = 71/296 (23%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ---------------- 45
           L+I+Y+D+ ++ VNKP+  +VH +  +    +V       +I                  
Sbjct: 138 LDIVYEDDHVLVVNKPAHMVVHPAPGNAKGTLVNAILHHCKISTFTCLARSSAGDECPDS 197

Query: 46  ---------------------------HVFTAHRLDRPTSGVLLMGLSSEAGRLLAQQFE 78
                                           HRLD+ TSG+L++     +   LA+QF+
Sbjct: 198 SDEDTDVFHVDQFAAEDVSSEVRNALVRPGIVHRLDKGTSGLLVVAKDEHSHARLAEQFK 257

Query: 79  QHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADKFAREDKG---PQPAVTHYRGLAT 134
            H I++ Y ++  G        ++  +  + +      A    G    + A + Y+    
Sbjct: 258 LHTIRRVYISLTCGAPNPNSGRIEASIARDPNNRIRMTAIAGSGHRYARNAASRYKVREV 317

Query: 135 VEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHGDLRQNRSGAEHF 194
                           LVE   +TGR HQ+R H  ++  P++GD  +G  +         
Sbjct: 318 F---------AGGGSALVEWRLETGRTHQIRAHAKYIGIPLLGDETYGGTQSMALSLLRP 368

Query: 195 G---------------LQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFG 235
                           + R  LHA+ L   HP +G+ L       D +++ L +  
Sbjct: 369 RSPSKYHSGLSNLLSKVDRPCLHAASLGFKHPRSGKVLEFSCPPPDDFLEVLGELR 424


>UniRef50_B7GEZ0 Pseudouridine synthase n=7 Tax=Bacillaceae RepID=B7GEZ0_ANOFW
          Length = 315

 Score =  271 bits (693), Expect = 2e-71,   Method: Composition-based stats.
 Identities = 66/229 (28%), Positives = 105/229 (45%), Gaps = 25/229 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG---QHVFTAHRLDRPTS 58
           L I+++D+ ++ VNK +   VH +   +   +        Q       V   HRLDR TS
Sbjct: 96  LHIVFEDDHVLVVNKRAHMDVHPTQPGQTNTLANAVAFHFQCEGIYSKVRHIHRLDRDTS 155

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADKFAR 117
           GV+L    + AG +L Q   +  I++ Y A+V G++  ++  ++ P+  +      +   
Sbjct: 156 GVILFAKHALAGAILDQYLAKRTIRRTYIALVHGYVKQKKGTIEAPIGRDRHHPTRRRV- 214

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
             K    A+THY  L   +              LV L   TGR HQ+R H++++ HP++G
Sbjct: 215 -SKTGDTAITHYERLQYDKQK---------HVSLVRLTLDTGRTHQIRVHMSYIGHPLVG 264

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDT 226
           D+ +G             + R  LHA  LS  HPFT E +T  A L D 
Sbjct: 265 DTLYGGKPW---------IDRQALHAFSLSFLHPFTEELITCSA-LPDE 303


>UniRef50_Q126H9 Pseudouridine synthase n=1 Tax=Polaromonas sp. JS666
           RepID=Q126H9_POLSJ
          Length = 378

 Score =  271 bits (693), Expect = 2e-71,   Method: Composition-based stats.
 Identities = 78/256 (30%), Positives = 120/256 (46%), Gaps = 17/256 (6%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
             +L++D++L+A++KP+G  VH         +  ++  R Q    +   HRLDR TSG+L
Sbjct: 126 FPVLFEDDFLLAIDKPAGVAVHGGSGVSFGVIEQLRMARPQ-ADFLELVHRLDRETSGIL 184

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRG-WLMEEAVLDYPLVE--------ELDKIA 112
           L+     A +LL +QF + +  K Y A+V G W     V+D  L +        E ++  
Sbjct: 185 LIAKRRMALKLLQEQFRERETDKVYLALVSGNWPANHRVIDKALHKYLLPGGAGEGERRV 244

Query: 113 DKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLR 172
                +      +VT  +  +      A    P T + L+E+  KTGR HQ+R HLA+  
Sbjct: 245 KVVPNDHPDGMRSVTLVKVKSAF---AALPAAPGTPFTLLEVTIKTGRTHQIRVHLANEG 301

Query: 173 HPIIGDSKHGDLRQNRSGAEHF----GLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWM 228
           HPI GD K+GD   N+S  +       L+R+ LHA  L   HP T + + +   L D   
Sbjct: 302 HPIAGDDKYGDFELNKSLQKSVAGGAPLKRMFLHAWSLKFNHPKTRKTIHLETPLPDELQ 361

Query: 229 QALSQFGWRGLLPENE 244
           Q LS        P  +
Sbjct: 362 QFLSVRPQGSAGPAAQ 377


>UniRef50_A6TSZ4 Pseudouridine synthase n=1 Tax=Alkaliphilus metalliredigens QYMF
           RepID=A6TSZ4_ALKMQ
          Length = 308

 Score =  270 bits (692), Expect = 3e-71,   Method: Composition-based stats.
 Identities = 52/240 (21%), Positives = 103/240 (42%), Gaps = 24/240 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVM---QTVRDQIGQHVFTAHRLDRPTS 58
             ++Y+D  ++ +NK  G + H +     + +         +  +   +   +RLD  TS
Sbjct: 86  FNVVYEDIDVIVINKEPGIVSHPTKSHPKDTIANAAQNYLEKKGVACRIRFVNRLDMDTS 145

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRG-WLMEEAVLDYPLVEELDKIADKFAR 117
           G+L++  +     +++QQ + ++I K+Y A V+G  +  E  +D  +    D+   +   
Sbjct: 146 GLLVIAKNPYTHHIMSQQMKANEITKKYVAFVKGVVVANEGEIDGAIYRSSDETIKRVV- 204

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
            D   Q ++T +  L                  ++E+   TGR HQ+R H+  + HP++G
Sbjct: 205 -DDRGQQSLTKFTVLERY-----------ADATMLEVSLLTGRTHQIRVHMESIGHPMLG 252

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWR 237
           D  +G         +   ++R  LHAS LS   P   E + + A L     +  ++    
Sbjct: 253 DHLYG-------YVDTELIRRQALHASYLSFLQPRYKEKIEVRASLPKDLNELRNKLKDE 305


>UniRef50_A6VXE8 Pseudouridine synthase n=2 Tax=Marinomonas RepID=A6VXE8_MARMS
          Length = 242

 Score =  270 bits (691), Expect = 4e-71,   Method: Composition-based stats.
 Identities = 102/236 (43%), Positives = 145/236 (61%), Gaps = 1/236 (0%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           L+IL+QDE LVAVNKP+G LVHR+ L +DE+  V+Q +RDQ G+ VF  HRLDR TSGVL
Sbjct: 3   LDILFQDEHLVAVNKPAGLLVHRTNLAKDEEDAVVQRLRDQTGKWVFPVHRLDRGTSGVL 62

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKG 121
           +M  S E  R L+ QF + + QK YH +VRG+  E  V++YPL +  ++      + +  
Sbjct: 63  VMAFSPEVARRLSTQFAESKTQKTYHCLVRGYCNESGVINYPLAKLNEQKGRSRFKIEGT 122

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
            + A T +  L   ++PV   RY + R   +E+ PK GRKHQ+RRH  H  +P++GDS +
Sbjct: 123 EREAETGFTRLIQYQLPVPVSRYDSMRLSWLEVTPKQGRKHQIRRHFKHHLNPLVGDSCY 182

Query: 182 GDLRQNRSGAEHFGLQ-RLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGW 236
           G    N+   E +    RLMLHAS L   HP T +P+T+ A L D  +  L++  +
Sbjct: 183 GCRHINKVAKELWSEDFRLMLHASSLEFNHPITNQPITLKADLSDKIINILNKLEY 238


>UniRef50_A0L8J2 Pseudouridine synthase n=1 Tax=Magnetococcus sp. MC-1
           RepID=A0L8J2_MAGSM
          Length = 328

 Score =  270 bits (691), Expect = 4e-71,   Method: Composition-based stats.
 Identities = 79/237 (33%), Positives = 125/237 (52%), Gaps = 15/237 (6%)

Query: 5   LYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHV--FTAHRLDRPTSGVLL 62
           L++D W++ +NKP+G  VH     +   V  ++   +++G        HRLD+ TSG+LL
Sbjct: 101 LHRDGWILVLNKPAGIPVHGGSGHQWGVVDAVRASLEKLGIEAQAELCHRLDKETSGLLL 160

Query: 63  MGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADKFAREDKG 121
            GL   A RLL +   ++Q+ K Y  +V+G     + V++ PL +   +  ++    ++G
Sbjct: 161 FGLRPRAVRLLTEAMRENQVTKTYLTLVQGVPAARQGVINQPLSKGNVRGGERMVVVEQG 220

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
            Q AVTHYR L +  +             L+E++ +TGR HQ+R H+  L HP+ GD K+
Sbjct: 221 GQRAVTHYRVLRSYGV-----------ASLLEVQLETGRTHQIRVHMQWLGHPVAGDGKY 269

Query: 182 GDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWRG 238
           GD   N+   E  GL+RL LHAS+L+  HP   + L   A LDD   + L     + 
Sbjct: 270 GDKAFNKWMRER-GLKRLFLHASELAFRHPENEQKLAYQAPLDDELTRVLEGLKRQE 325


>UniRef50_C0E4Q3 Pseudouridine synthase n=2 Tax=Corynebacterium matruchotii
           RepID=C0E4Q3_9CORY
          Length = 310

 Score =  269 bits (690), Expect = 5e-71,   Method: Composition-based stats.
 Identities = 68/243 (27%), Positives = 98/243 (40%), Gaps = 23/243 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVR------DQIGQHVFTAHRLDR 55
           LEILY DE L+AV+KP G   H +       VV                +      RLD 
Sbjct: 83  LEILYADEDLIAVDKPVGVAAHPTVGWDGPTVVGGLAAAGYRISTSGPPERNGIVQRLDV 142

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADK 114
            TSGV+++  S     +L + F++  + K YHA+V+G +      ++  +          
Sbjct: 143 GTSGVMVVAASERGYSVLKRAFKERTVSKTYHALVQGHMDPLAGTIEANIGRHPSSGWKF 202

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
               D   + AVTHY  L                  L+E+  +TGR HQ+R H++ L HP
Sbjct: 203 AVTSD--GKHAVTHYETLEAFVA-----------ASLLEVHLETGRTHQIRVHMSALHHP 249

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
             GD  +G    +   +   GL R  LHA +L   HP  G  L I +        AL   
Sbjct: 250 CCGDPMYG---ADPQLSARLGLNRQWLHAVKLGFYHPADGRWLEIESPYPPDLRHALEVL 306

Query: 235 GWR 237
              
Sbjct: 307 RAE 309


>UniRef50_C2W5F3 Pseudouridine synthase n=4 Tax=Bacillus RepID=C2W5F3_BACCE
          Length = 307

 Score =  269 bits (690), Expect = 6e-71,   Method: Composition-based stats.
 Identities = 57/237 (24%), Positives = 105/237 (44%), Gaps = 23/237 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVR---DQIGQHVFTAHRLDRPTS 58
           LE++++D+ ++ VNKP+    H S       +  +         +   V   HRLD+ T+
Sbjct: 85  LEVIFEDDHVLIVNKPAHMDTHPSNKGGTGTLANLVAFHLQMQGVETKVRHIHRLDKDTT 144

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADKFAR 117
           G ++      AG ++ +   +  I++ Y A+V G +  ++ ++D  +  +      +   
Sbjct: 145 GGVVFAKHGIAGVIMDRLLMERNIKRTYLALVEGKVRKKQGIIDEAIGRDRHHATRRRV- 203

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
             +    AVTHY+     +              LV L+ +TGR HQ+R H++H  HP+IG
Sbjct: 204 -SQKGDRAVTHYKIEKYFK---------KQDVTLVTLQLETGRTHQIRVHMSHSGHPLIG 253

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           D  +G         +   +    LHA ++   HP T E +T+ A L +     +  F
Sbjct: 254 DVLYGG--------QATYMPYQALHAMRIHFLHPITKEEITVEAPLPNNLNNIIESF 302


>UniRef50_C0Z877 Pseudouridine synthase n=1 Tax=Brevibacillus brevis NBRC 100599
           RepID=C0Z877_BREBN
          Length = 310

 Score =  269 bits (689), Expect = 6e-71,   Method: Composition-based stats.
 Identities = 70/235 (29%), Positives = 108/235 (45%), Gaps = 24/235 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQH--VFTAHRLDRPTSG 59
           ++ILY+D+ L+  NKP+G +VH    + D  V  +  V    G+   V   HRLD+ TSG
Sbjct: 94  IDILYEDDHLLIANKPAGMMVHPIKQETDTLVHALAAVLAARGEQTSVHPVHRLDKDTSG 153

Query: 60  VLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADKFARE 118
            +L+  SS   +L  +   +  I + Y A+  G L E    +D P+  +      +   E
Sbjct: 154 AILVAKSSYGHQLADRLLREGGIHREYLAVASGVLSEGAGTIDAPIGRDARHPTKRRVVE 213

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
                PA+THY    T E              L  +  +TGR HQ+R H AH+ HP+ GD
Sbjct: 214 S--GDPAITHYEVQQTSE-----------EMTLARVWLETGRTHQIRVHFAHIGHPLAGD 260

Query: 179 SKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           + +G  R          L+R  LHAS+LS  HP   + + + A +     + +  
Sbjct: 261 TMYGGARG--------LLRRQALHASKLSFLHPLLEKEIVVEAPIPSDMKRLMQA 307


>UniRef50_Q89AH2 Ribosomal large subunit pseudouridine synthase C n=5 Tax=Buchnera
           aphidicola RepID=RLUC_BUCBP
          Length = 315

 Score =  269 bits (689), Expect = 7e-71,   Method: Composition-based stats.
 Identities = 66/232 (28%), Positives = 111/232 (47%), Gaps = 13/232 (5%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLM 63
           ILY+D + + +NKPSG  VH         +  ++ +R    +++   HRLDR TSGVL++
Sbjct: 95  ILYEDNYFLILNKPSGMSVHSGSGINYGMIENLRILRPY-NRYLDLVHRLDRDTSGVLII 153

Query: 64  GLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADKFAREDKGP 122
                  R L +Q  + +I+K+Y A+V G   +    +  PL++   +      + D   
Sbjct: 154 AKKRSILRNLHEQLREKKIKKKYVALVHGVWPDILKSISKPLLKTSSRKNKNIVKIDPKG 213

Query: 123 QPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHG 182
           + ++TH+                     L+ + P TGR HQ+R HL HL +PI+ D+K+G
Sbjct: 214 KESITHFNIKKKYTKN-----------TLISITPITGRTHQIRVHLLHLNYPIVLDAKYG 262

Query: 183 DLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
             + +      F + RL+LHA  ++  HP   + + I A LD  +   L   
Sbjct: 263 IKKLDYFIKNKFNINRLLLHAESINFFHPKRKKNILITAPLDYVFKTVLKNL 314


>UniRef50_P44433 Ribosomal large subunit pseudouridine synthase C n=22
           Tax=Gammaproteobacteria RepID=RLUC_HAEIN
          Length = 322

 Score =  269 bits (688), Expect = 8e-71,   Method: Composition-based stats.
 Identities = 72/234 (30%), Positives = 107/234 (45%), Gaps = 14/234 (5%)

Query: 3   EILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLL 62
           +IL++D+ L+ +NKPSG  VH         +  ++ +R    + +   HRLDR TSG+LL
Sbjct: 99  QILFEDDCLIILNKPSGIAVHGGSGLNFGVIEALRALR-PEARFLELVHRLDRDTSGILL 157

Query: 63  MGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADKFAREDKG 121
           +     A R L +Q     +QK Y A+VRG       V+   L++      ++  R  + 
Sbjct: 158 IAKKRSALRNLHEQLRVKTVQKDYLALVRGQWQSHIKVIQASLLKNELSSGERIVRVSEQ 217

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
            +P+ T +                     LV+  P TGR HQ+R H  +  HPI  D K+
Sbjct: 218 GKPSETRFSIEERYI-----------NATLVKASPVTGRTHQIRVHTQYAGHPIALDDKY 266

Query: 182 GDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFG 235
           GD   ++   E  GL RL LHA  +   HP  GE L  +A LD      L +  
Sbjct: 267 GDKDFDKQMNE-LGLNRLFLHAFSIRFEHPKNGETLRFNASLDHQMKAILQKLR 319


>UniRef50_A5VJ18 Pseudouridine synthase, RluA family n=13 Tax=Lactobacillus
           RepID=A5VJ18_LACRD
          Length = 301

 Score =  269 bits (688), Expect = 8e-71,   Method: Composition-based stats.
 Identities = 60/239 (25%), Positives = 104/239 (43%), Gaps = 27/239 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDR-DEKVVV----MQTVRDQIGQHVFTAHRLDRP 56
           ++I+Y+D+  + +NKP+G     +      + +V         ++   Q    A RLDR 
Sbjct: 78  IDIIYEDQDFLIMNKPAGVATVPAHNVPVADSLVNRVKGYYKRQNYENQVTHVATRLDRD 137

Query: 57  TSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRG-WLMEEAVLDYPLVEELDKIADKF 115
           TSG+++      A  +L +Q ++H ++K Y A+++G    E   +D P+  + +    + 
Sbjct: 138 TSGLVVFPKHRFAHAVLDEQLKKHLVKKNYLALIKGKVPAEHGYIDAPIQRDPNSFVKRM 197

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
               K  + +VT Y                  +  L+++   TGR HQ+R H A L  P+
Sbjct: 198 V--GKEGKASVTEYWRQEC-----------NVQASLIKIRLHTGRTHQIRVHFASLGFPL 244

Query: 176 IGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           IGD  +G         E   + R  LH   LS   PF G+ +T+ A L   +  A    
Sbjct: 245 IGDKMYG--------EESGLIARQALHCYWLSFYSPFKGKNITVSAPLPSDFKNAKDDL 295


>UniRef50_A1U2H1 Pseudouridine synthase n=1 Tax=Marinobacter aquaeolei VT8
           RepID=A1U2H1_MARAV
          Length = 245

 Score =  269 bits (688), Expect = 9e-71,   Method: Composition-based stats.
 Identities = 116/232 (50%), Positives = 153/232 (65%), Gaps = 3/232 (1%)

Query: 5   LYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRD-QIGQHVFTAHRLDRPTSGVLLM 63
           +Y+D+WL+AV+KP+G LVHRS +D+ E    +Q  R    G+HV+  HRLDRPTSGVLL 
Sbjct: 8   IYRDDWLLAVHKPAGLLVHRSPIDKHETEFALQYARAMNGGEHVYPVHRLDRPTSGVLLF 67

Query: 64  GLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKGPQ 123
               E  R L        + K Y A+VRGW  E+ V+D+PL EE +    K   +++  +
Sbjct: 68  ARDPETARALGLAMMAGAVSKTYLAMVRGWAPEQGVIDHPLREEPEDRRLKG--QEQPVR 125

Query: 124 PAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHGD 183
            A+T YR LAT E+PVA  RYPT+RY LVEL+P+TGRKHQLRRH+ H+ HPIIGD+ HG 
Sbjct: 126 EALTRYRRLATTELPVAIERYPTSRYSLVELKPETGRKHQLRRHMKHINHPIIGDANHGR 185

Query: 184 LRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFG 235
            R NR  AE FG  RLML A++L L HP T EPL + A  + +++Q L+ F 
Sbjct: 186 GRHNRYFAERFGQGRLMLAATELRLRHPVTDEPLCLKAHPESSFLQVLAIFE 237


>UniRef50_C8PZW5 Pseudouridine synthase n=1 Tax=Enhydrobacter aerosaccus SK60
           RepID=C8PZW5_9GAMM
          Length = 266

 Score =  269 bits (688), Expect = 9e-71,   Method: Composition-based stats.
 Identities = 133/266 (50%), Positives = 163/266 (61%), Gaps = 27/266 (10%)

Query: 1   MLEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGV 60
           MLEILYQDE  VAVNKP+G LVHRSWLDR E   VMQT+RDQ+ Q+V+  HRLDRPTSGV
Sbjct: 1   MLEILYQDEHCVAVNKPAGMLVHRSWLDRHETEFVMQTLRDQLAQYVYPIHRLDRPTSGV 60

Query: 61  LLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM----EEAVLDYPLVEELDKIA---- 112
           LL  LSSE+ R L +QFE  Q+QK Y AIVRG+L        ++DYPL + LDKI     
Sbjct: 61  LLFALSSESARQLCEQFENRQVQKSYLAIVRGYLTVNAQTSGLIDYPLTQILDKIGDKPS 120

Query: 113 ------DKFAREDKGP------------QPAVTHYRGLATVEMP-VATGRYPTTRYGLVE 153
                  K +  D               QPA TH++ LAT E P  A  RYPT+R+ L  
Sbjct: 121 LQALQQRKVSSTDMFAEALSSPAELTLLQPAQTHWQCLATTEQPFQARARYPTSRFSLAR 180

Query: 154 LEPKTGRKHQLRRHLAHLRHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFT 213
           L P TGRKHQLRRH+ H+ HPIIGD+ +GD  QNR+  +H G+ RLMLHA  L+      
Sbjct: 181 LTPITGRKHQLRRHMKHVFHPIIGDTSYGDHHQNRAIRQHIGVHRLMLHAHTLAFNRLTD 240

Query: 214 GEPLTIHAGLDDTWMQALSQFGWRGL 239
              + I A +D  W+   +QFG+   
Sbjct: 241 NRRVDITAPVDTDWLTMCAQFGFHLP 266


>UniRef50_A6LDZ7 Pseudouridine synthase n=26 Tax=Bacteroidales RepID=A6LDZ7_PARD8
          Length = 549

 Score =  268 bits (687), Expect = 1e-70,   Method: Composition-based stats.
 Identities = 76/234 (32%), Positives = 107/234 (45%), Gaps = 35/234 (14%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           L+ILY+D++L+ +NKP G L      D D     +  +           HRLD  TSG+L
Sbjct: 340 LDILYEDDYLLVINKPEGMLSVPGKGDADSVYQRLSILY-PEATGPIIVHRLDMATSGLL 398

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADKFAREDK 120
           L   + EA + L  QF+   IQKRY A++ G +  +E  +  PL  +      +   E+ 
Sbjct: 399 LAAKTKEAHQNLQAQFKNRTIQKRYIALLEGEVPQDEGEIRLPLCPDPLDRPRQIVSEEF 458

Query: 121 GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAH---LRHPIIG 177
             +PA+THYR L             T+   L+   P+TGR HQLR H AH   L  PI+G
Sbjct: 459 -GKPALTHYRVLER-----------TSGKTLIAFYPQTGRTHQLRVHAAHPLGLHCPILG 506

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIH-------AGLD 224
           D  +G              +RL LHA  L+ THP T E + I          + 
Sbjct: 507 DELYGRK-----------AERLYLHAEYLAFTHPITSERIEIQKSPAFPRCPMP 549


>UniRef50_D2ELJ1 Pseudouridine synthase n=1 Tax=Pediococcus acidilactici 7_4
           RepID=D2ELJ1_PEDAC
          Length = 301

 Score =  267 bits (685), Expect = 2e-70,   Method: Composition-based stats.
 Identities = 57/237 (24%), Positives = 104/237 (43%), Gaps = 23/237 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVV----MQTVRDQIGQHVFTAHRLDRPT 57
           ++++Y+D+  + VNKP      +S  ++ + +V         RD   Q V    RLD+ T
Sbjct: 78  IDVIYEDQDYLVVNKPPFLPTVQSARNQTDTLVNRVKNYYAERDYESQVVHVVTRLDQDT 137

Query: 58  SGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADKFA 116
           SG++L      A  ++ Q   QH++QK Y A+  G   +   ++D P+  +      +  
Sbjct: 138 SGLVLFAKRRFAHTIMDQDLRQHRVQKYYLAMATGRFAQSHGLIDAPIERDPASFIKRRV 197

Query: 117 REDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPII 176
                 +P+ T Y  L   +              L++++  TGR HQ+R H + L HP+I
Sbjct: 198 ASAGNGKPSKTEYWVLEQTDTD-----------SLLKVQLHTGRTHQIRVHFSELHHPLI 246

Query: 177 GDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           GD  +       +      LQR  LH   L   + F G+ + + A + +  ++   +
Sbjct: 247 GDPLY-------NETSFRSLQRQALHCFSLKFENVFRGKKIDVQAPIPNDMLEYWKK 296


>UniRef50_UPI0001AEC02F pseudouridylate synthase, 23S RNA-specific n=1 Tax=Alteromonas
           macleodii ATCC 27126 RepID=UPI0001AEC02F
          Length = 279

 Score =  267 bits (685), Expect = 2e-70,   Method: Composition-based stats.
 Identities = 117/233 (50%), Positives = 153/233 (65%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           L +LYQDE ++A+ KP G LVHRS +DR E V  +QT+RDQIGQHV+ AHRLDRPTSGVL
Sbjct: 42  LPVLYQDEHIIAIEKPPGLLVHRSPIDRHETVFAVQTLRDQIGQHVYPAHRLDRPTSGVL 101

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKG 121
           +   SSE    L QQ    Q+ K YHAIVRG++     +DY L    DKIADK  R  + 
Sbjct: 102 VFSFSSEIAAKLGQQMMDKQVVKTYHAIVRGFVHHTGYIDYALKYRYDKIADKHKRPQQP 161

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
           PQPA T Y+ +A  E+P   G+Y + RY LV+L P TGRKHQLRRH+ H+RHPIIGD+ H
Sbjct: 162 PQPASTMYQSVAKFEVPEPVGKYQSARYSLVKLSPSTGRKHQLRRHMVHIRHPIIGDTTH 221

Query: 182 GDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           GD +QN+   +HF    L L  +Q+  +HP TG+ ++I++ +       L + 
Sbjct: 222 GDGKQNKFAKQHFNFNNLALSCTQMGFSHPVTGKWVSINSQMHSEMRLWLEKL 274


>UniRef50_A7H6D3 Pseudouridine synthase n=6 Tax=Cystobacterineae RepID=A7H6D3_ANADF
          Length = 339

 Score =  267 bits (684), Expect = 3e-70,   Method: Composition-based stats.
 Identities = 80/260 (30%), Positives = 124/260 (47%), Gaps = 23/260 (8%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVR-------DQIGQHVFTAHRLDRP 56
           +L++D  ++AV+KP+G   H         +V M                    AHRLDR 
Sbjct: 87  VLHEDADVLAVDKPAGLAAHPGTGISGATLVEMARAHLGTPADLPPTEFKPSPAHRLDRD 146

Query: 57  TSGVLLMGLSSEAGRLLAQQFEQH-QIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADK 114
           TSGV+L+  + +    L + F     ++K Y A+V+G +  E   +D PL E       K
Sbjct: 147 TSGVVLVAKNRKTMVRLTELFTDGADVKKTYLALVKGKMPREAGTIDLPLAEHEQTARSK 206

Query: 115 FAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
            AR     Q A+T ++ ++                 L+ +  +TGR HQ+RRHL  + HP
Sbjct: 207 AARGV-NLQEALTRWKVVS-----------AMKEASLLAVTIETGRTHQIRRHLEAVGHP 254

Query: 175 IIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           ++GD ++GD   NR+  + +GL+R+ LHA +L L HP TG PL + A L    ++ALS+ 
Sbjct: 255 VLGDRRYGDFPTNRAARQRWGLRRMFLHAWRLELPHPTTGAPLRLEAPLPGELLEALSRA 314

Query: 235 GWRGLLPENERVEFSAPSGQ 254
                 P       +AP G 
Sbjct: 315 NLSS--PAGTASGRAAPRGA 332


>UniRef50_D2M2K8 Pseudouridine synthase, RluA family n=1 Tax=Bacillus
           cellulosilyticus DSM 2522 RepID=D2M2K8_BACS4
          Length = 298

 Score =  267 bits (684), Expect = 3e-70,   Method: Composition-based stats.
 Identities = 58/237 (24%), Positives = 111/237 (46%), Gaps = 25/237 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVV---VMQTVRDQIGQHVFTAHRLDRPTS 58
           L I+++DE ++ +NKP       +  + +  +    +   + + I        RLDR TS
Sbjct: 83  LHIIFEDEHVIIINKPPHLPTIPTRNEGEPSLAGAILAYYIENGIPSTFHAVSRLDRDTS 142

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADKFAR 117
           G++++        L  +  + ++I++ Y A+V G L ++   +D P+  +   I ++   
Sbjct: 143 GLVMVAKHRYMHDLCVKLQKSYEIKRSYVALVEGILSDDYNTIDLPISRKTTSIIEREV- 201

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
            ++  + A+THY  L              +   L++L  +TGR HQ+R H++ + HP++G
Sbjct: 202 -NEFGKSAITHYEVLKRY-----------SGATLLQLTLETGRTHQIRVHMSAIGHPLLG 249

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           D+ +G         +   + R  LH+ QLS  HP      T H  + D    A+S+F
Sbjct: 250 DTLYGG--------DVRYIDRQALHSHQLSFFHPINKREYTFHCPIPDDIEDAMSKF 298


>UniRef50_A4J479 Pseudouridine synthase n=1 Tax=Desulfotomaculum reducens MI-1
           RepID=A4J479_DESRM
          Length = 303

 Score =  267 bits (683), Expect = 3e-70,   Method: Composition-based stats.
 Identities = 71/236 (30%), Positives = 113/236 (47%), Gaps = 25/236 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKV---VVMQTVRDQIGQHVFTAHRLDRPTS 58
           L ILY+D  L+AVNKP G LVH    +    +   V+   ++          HRLDR TS
Sbjct: 84  LNILYEDAHLLAVNKPPGMLVHPLTNETSGTLANGVLYHWLQQGTIDRFRPVHRLDRNTS 143

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADKFAR 117
           G++L+  +    + L  Q +Q Q  +RY A+V+G +  E+ V+  P+  E      +   
Sbjct: 144 GIVLIARNPYVQQQLQIQMKQGQFVRRYLALVKGKVQPEQGVIQAPIALEEGSFIKRMI- 202

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
                + A++HY+ L T             +  LV +E +TGR HQ+R H+AH+ HP++G
Sbjct: 203 -SPAGKEAISHYQVLRTF-----------NQASLVRVELETGRTHQVRVHMAHMGHPLLG 250

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           DS +G    N        ++R  LH + L+  HP  G  + I   +     Q + +
Sbjct: 251 DSLYGGDTSN--------IKRQALHCAYLAFNHPVQGSRIKISCSVAGDIRQLMEE 298


>UniRef50_Q8ERS8 Pseudouridine synthase n=2 Tax=Bacillaceae RepID=Q8ERS8_OCEIH
          Length = 322

 Score =  267 bits (683), Expect = 3e-70,   Method: Composition-based stats.
 Identities = 60/237 (25%), Positives = 107/237 (45%), Gaps = 24/237 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVV---MQTVRDQIGQHVFTAHRLDRPTS 58
           L+I+Y+D + + VNKP+G     S   R   +         ++ I   V    RLD  TS
Sbjct: 103 LDIIYEDAYCLVVNKPAGQACLPSMNHRHNTLANGLTYYYQKNSIPSTVHIVTRLDVNTS 162

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADKFAR 117
           G++L+  +     L ++  ++  I + Y AIV G +     ++D P+  +   I ++   
Sbjct: 163 GLVLVAKNQYVHSLFSRMQQEGNINRVYEAIVHGEVSPTSGIVDAPIARKEGSIIERTVD 222

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
             +  + A T+YR L           Y  +    VE++ +TGR HQ+R H  +L H + G
Sbjct: 223 M-RNGKYAKTNYRVL-----------YADSIASWVEIKLETGRTHQIRVHFQYLGHSLYG 270

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           D+ +G  +          + R  LH  Q+++ HP   +P+ + A L +     L + 
Sbjct: 271 DNLYGGSKD--------IMLRQALHCKQITMMHPIKNQPIQLEASLPEDMGILLKRL 319


>UniRef50_B1XXM0 Pseudouridine synthase n=6 Tax=Burkholderiales RepID=B1XXM0_LEPCP
          Length = 369

 Score =  267 bits (683), Expect = 3e-70,   Method: Composition-based stats.
 Identities = 66/229 (28%), Positives = 103/229 (44%), Gaps = 19/229 (8%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVV---MQTVRDQIGQHVFTAHRLDRPTS 58
           L ++++D  L+ ++KP+G +VH +       ++                   HRLD+ TS
Sbjct: 119 LAVVHEDAHLLVIDKPAGLVVHPAAGHWSGTLLNGLLAHHAAAAHLPRAGIVHRLDKDTS 178

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADKFAR 117
           G++L+  S +A   L +      +++ Y A+V G +M+   V+D PL  +          
Sbjct: 179 GLMLVAKSLQAHTALVRAIAARDVKREYLALVHGAVMDGLQVIDAPLGRDPVSRVRMAIV 238

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTT------RYGLVELEPKTGRKHQLRRHLAHL 171
                +PA T  R LA  E+P    R          +   V  +  TGR HQ+R HLA  
Sbjct: 239 AS--GKPARTDVRRLAVAELPGDGVRQLPGATRAPRQVSAVHCQLHTGRTHQIRVHLASR 296

Query: 172 RHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIH 220
            HP++ D+ +G           FGLQR  LHA++L L HP  G PL   
Sbjct: 297 GHPLLADAMYGGAP-------AFGLQRQALHAARLHLLHPIDGRPLAFE 338


>UniRef50_D2QPA6 Pseudouridine synthase n=1 Tax=Spirosoma linguale DSM 74
           RepID=D2QPA6_9SPHI
          Length = 244

 Score =  266 bits (682), Expect = 4e-70,   Method: Composition-based stats.
 Identities = 111/233 (47%), Positives = 143/233 (61%), Gaps = 6/233 (2%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           L ILYQD  LVA+NKP G LVHRS +  D     +Q +RDQ+GQ V+  HRLDR T+GVL
Sbjct: 11  LSILYQDTELVAINKPHGLLVHRSMIASDASEFAVQLLRDQLGQRVYPVHRLDRKTAGVL 70

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKG 121
           L  LS     ++ QQF +  +QK Y AIVRG+  +E  +DYPL ++    A         
Sbjct: 71  LFALSESMNAIMQQQFMEGAVQKTYLAIVRGYTPDELTIDYPLCKDDGNGAVGVL----- 125

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
            Q AVTH + L   E+PVA G++PT+RY LVEL P TGR HQLRRH+AH+ HPIIGD  H
Sbjct: 126 -QEAVTHLKTLRQTEIPVAFGKHPTSRYSLVELTPTTGRMHQLRRHMAHILHPIIGDRPH 184

Query: 182 GDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           G  +QN+   EHF +  ++LHA ++  THP T E  TI A     + + L   
Sbjct: 185 GCNKQNKLFKEHFEMNTMLLHAQRIEFTHPVTQETTTIAAPFQAEFRRMLGVL 237


>UniRef50_Q3JQ55 Pseudouridine synthase n=170 Tax=cellular organisms
           RepID=Q3JQ55_BURP1
          Length = 477

 Score =  266 bits (682), Expect = 5e-70,   Method: Composition-based stats.
 Identities = 80/240 (33%), Positives = 119/240 (49%), Gaps = 19/240 (7%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
            EIL++D+ ++ +NKP+G  VH         +  M+  R    + +  AHRLDR TSG+L
Sbjct: 243 FEILFEDDAIIVLNKPAGVAVHGGSGVAFGVIEQMRHARPH-AKFLELAHRLDRETSGIL 301

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE----AVLDYPLVEELDKIADKFAR 117
           ++     A   L +Q  ++++ KRY A V G    +     V+  PL +      ++  R
Sbjct: 302 MLAKKRSALVGLHEQIRENRMDKRYFACVHGDWAADWGRRRVVKAPLFKYATPDGERRVR 361

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
             +   P+ T +  +                Y LVE E KTGR HQ+R HLAHL  PI+G
Sbjct: 362 VQEDGLPSHTVFNLVDRWP-----------DYALVEAELKTGRTHQIRVHLAHLGLPIVG 410

Query: 178 DSKHGDLRQNRSGAEH---FGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           D+K+GD   N++ A       ++R+ LHA +L L HP TGEPL   A L     Q + Q 
Sbjct: 411 DAKYGDFALNKALARANAVPSIKRMFLHAHRLRLAHPLTGEPLQFDAPLPAECRQFIDQL 470


>UniRef50_C7GZW0 Pseudouridine synthase n=1 Tax=Eubacterium saphenum ATCC 49989
           RepID=C7GZW0_9FIRM
          Length = 318

 Score =  266 bits (682), Expect = 5e-70,   Method: Composition-based stats.
 Identities = 56/240 (23%), Positives = 106/240 (44%), Gaps = 27/240 (11%)

Query: 2   LEI--LYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRD---QIGQHVFTAHRLDRP 56
           +EI  +Y+DE L+ ++KP+G +VH +    +  +                +   +RLD  
Sbjct: 94  IEINAVYEDEHLLVIDKPAGIVVHPTHGYEENTIAHALIHYMDTVGEEFKIRFINRLDMD 153

Query: 57  TSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADKF 115
           T+G+L++  +      +  + ++  ++KRY A+V G     E ++D P+     +   + 
Sbjct: 154 TTGLLMIAKNQFIQNAVVSEMKRGNVEKRYLAVVHGLPCNREGIIDAPIKAVEGEPRRQV 213

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
               +G +P++T Y+ +         G         +++   TGR HQ+R HL H+  PI
Sbjct: 214 M---EGGKPSITEYKVV---------GVSDELNVSFLDVRLHTGRTHQIRVHLKHIGCPI 261

Query: 176 IGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFG 235
           +GD  +G               R +LH+  L  THP + + + + A L D     L+   
Sbjct: 262 LGDEFYGGKES---------ADRQLLHSRYLRFTHPVSKKIVELTANLPDDIASILTHMQ 312


>UniRef50_A3ZV48 Pseudouridine synthase n=1 Tax=Blastopirellula marina DSM 3645
           RepID=A3ZV48_9PLAN
          Length = 281

 Score =  266 bits (681), Expect = 6e-70,   Method: Composition-based stats.
 Identities = 64/251 (25%), Positives = 97/251 (38%), Gaps = 28/251 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRD------QIGQHVFTAHRLDR 55
           L+I+YQD+ +  +NKP+G + H +       +      +                HRLDR
Sbjct: 39  LDIIYQDDRIAVINKPAGMITHPAKGHWKGTLTEGLKGQFPQLSTIGGPTRPGIVHRLDR 98

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEA-VLDYPLVEELDKIADK 114
            TSGV+++     A   L  QF+    +K Y A+V G    +  +++ P+          
Sbjct: 99  DTSGVIVIAKDDAAHEFLKTQFQDRLTEKEYFAMVIGAPDRDRDLINEPVGPHPKIRERM 158

Query: 115 FARE-DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRH 173
             R  D   + A T Y  L                +  ++  PKTGR HQ+R HL H  H
Sbjct: 159 AIRRGDDEGKDAQTFYEVLERY-----------QGFAAIKALPKTGRTHQIRVHLMHAGH 207

Query: 174 PIIGDSKHGDLR------QNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTW 227
           P++ D  +G  R                L R  LHA ++++ HP  GE     A L    
Sbjct: 208 PVLCDPLYGSRRFLSLGELQHDDDRTVLLNRTALHAHRIAIAHPDDGEIREFIAPLPADL 267

Query: 228 ---MQALSQFG 235
                 L Q  
Sbjct: 268 ERTQNMLRQLR 278


>UniRef50_Q8ZFU1 Ribosomal large subunit pseudouridine synthase C n=102
           Tax=Gammaproteobacteria RepID=RLUC_YERPE
          Length = 320

 Score =  266 bits (681), Expect = 6e-70,   Method: Composition-based stats.
 Identities = 73/233 (31%), Positives = 111/233 (47%), Gaps = 14/233 (6%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLM 63
           IL++D++L+ +NKPSG  VH         +  ++ +R    + +   HRLDR TSGVLL+
Sbjct: 95  ILFEDDYLLVLNKPSGTAVHGGSGLSFGVIEGLRALR-PEARFLELVHRLDRDTSGVLLV 153

Query: 64  GLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADKFAREDKGP 122
                A R L +Q     +QK Y A+VRG        +  PL++ + +  ++  +     
Sbjct: 154 AKKRSALRSLHEQLRLKSMQKDYLALVRGQWQSHCKAIQAPLLKNIMQSGERVVKVSSEG 213

Query: 123 QPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHG 182
           +P+ T ++     E              LV+  P TGR HQ+R H  H  HPI  D ++G
Sbjct: 214 KPSETRFKIEERFE-----------HATLVKASPVTGRTHQIRVHALHAGHPIAFDDRYG 262

Query: 183 DLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFG 235
               ++   +  GL RL LHA+ L   HP TGE + I A LD+     L    
Sbjct: 263 YREFDQQL-QGTGLHRLFLHAAALRFEHPNTGETMRIEAPLDNQLRHCLLALR 314


>UniRef50_C0EHV8 Putative uncharacterized protein n=1 Tax=Clostridium methylpentosum
           DSM 5476 RepID=C0EHV8_9CLOT
          Length = 299

 Score =  266 bits (680), Expect = 7e-70,   Method: Composition-based stats.
 Identities = 61/236 (25%), Positives = 103/236 (43%), Gaps = 24/236 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQH---VFTAHRLDRPTS 58
            +I Y+D+ L+ VNKP+G  VH S    ++ +      +    +        +RLDR TS
Sbjct: 80  FDIAYEDDDLLLVNKPAGTPVHPSPGHYEDSLANYSAWQYAQRREQLVFRPVNRLDRGTS 139

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADKFAR 117
           G+L +  ++ A   L+QQ      ++ Y+A+V G        +D P+      +  +   
Sbjct: 140 GLLCVAKNAHAQARLSQQLHTGAFERIYYAVVCGAPSPAAGTIDLPIGRTPGSVLKRRV- 198

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
            D     AVTHY  +                Y L+++  +TGR HQ+R H AHL  P+ G
Sbjct: 199 -DPQGARAVTHYETVR-----------VNGAYTLLKIRLETGRTHQIRVHFAHLGCPLFG 246

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           D  +G  R++        ++   LH+ ++ L HP +GE +     L       +  
Sbjct: 247 DFLYGTERRDV-------VEGHALHSGEIRLLHPISGEEIRCSVPLPAYMENLMDN 295


>UniRef50_C8NZX3 Pseudouridine synthase n=1 Tax=Erysipelothrix rhusiopathiae ATCC
           19414 RepID=C8NZX3_ERYRH
          Length = 298

 Score =  266 bits (680), Expect = 8e-70,   Method: Composition-based stats.
 Identities = 54/238 (22%), Positives = 99/238 (41%), Gaps = 24/238 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ----HVFTAHRLDRPT 57
           ++++Y+DE+L+ VNKP G +VH     + + ++                    HR+DR T
Sbjct: 77  IDVVYEDEYLLVVNKPRGLVVHPGNGVKSDTLLHGLLYYLNSNCDHYIRPGLVHRIDRNT 136

Query: 58  SGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAV-LDYPLVEELDKIADKFA 116
           SG+L++    +  + LA+Q     + + Y+A+V G L +  V +D P+  +         
Sbjct: 137 SGLLVIAKDDKTHQFLAEQLLDKTMNRTYYALVHGVLPQAHVLIDAPIGPDKSN-TKIMT 195

Query: 117 REDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPII 176
                 +PA TH+  + T                L+  + +TGR HQ+R H  H   P+ 
Sbjct: 196 VNQARSKPARTHFEKIETYINS-----------SLICCKLETGRTHQIRVHALHANIPLH 244

Query: 177 GDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           GD ++G                  L A++L   HP   + +     L   +   +++ 
Sbjct: 245 GDPQYGHPSDTDKT-------GQYLCAARLEFVHPKYLKLMQFEIPLPRYFQDKITEL 295


>UniRef50_C5RBB6 23S rRNA pseudouridylate synthase RluD n=1 Tax=Weissella
           paramesenteroides ATCC 33313 RepID=C5RBB6_WEIPA
          Length = 305

 Score =  266 bits (680), Expect = 8e-70,   Method: Composition-based stats.
 Identities = 66/235 (28%), Positives = 105/235 (44%), Gaps = 25/235 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVV---MQTVRDQIGQ-HVFTAHRLDRPT 57
           ++ILY+DE  + V+K +G        DR+  +V       + +           RLDR T
Sbjct: 79  IKILYEDENWLVVDKVAGVTSVPGKADRETTMVNRVKGYLISEGAEDLVPHVVTRLDRFT 138

Query: 58  SGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADKFA 116
           SGV L+     A  LL +Q + H + KRY+AIV G + ++   +D P+    +    +  
Sbjct: 139 SGVALLAKHRFAHGLLDKQLQTHTVDKRYYAIVDGIVPDDHGFIDAPIGRMDNDFIRREV 198

Query: 117 REDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPII 176
           R D   +P+ T Y  +  +               LV+++  TGR HQ+R H  ++ HP+I
Sbjct: 199 RAD--GRPSQTEYWVVNRMPNQ-----------TLVKVQLHTGRTHQIRVHFKYIGHPLI 245

Query: 177 GDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
           GD  +G            G++R  LHA  L    PF+     I + L +   Q L
Sbjct: 246 GDEIYGG-------PMDRGIERQALHAYWLEFYDPFSEIKRHIQSPLPEDLKQIL 293


>UniRef50_Q03EW7 Pseudouridine synthase n=1 Tax=Pediococcus pentosaceus ATCC 25745
           RepID=Q03EW7_PEDPA
          Length = 253

 Score =  265 bits (679), Expect = 1e-69,   Method: Composition-based stats.
 Identities = 53/237 (22%), Positives = 106/237 (44%), Gaps = 23/237 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVM---QTVRDQIGQHV-FTAHRLDRPT 57
           +++ Y+D   + VNKP      +S  ++ + +V       V++     V     RLD+ T
Sbjct: 28  IDVRYEDADYLIVNKPPFLPTVQSAANQKDTLVNRVKNYYVKNNYESRVVHVVTRLDQDT 87

Query: 58  SGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLM-EEAVLDYPLVEELDKIADKFA 116
           SG+++      A  ++ Q   Q +I K Y  IV G    +  +++ P+  + D    +  
Sbjct: 88  SGLVIFAKHRFAHTVMDQDLRQRKINKMYLTIVEGTFTNQHGIIETPIQRDPDSFIKRMV 147

Query: 117 REDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPII 176
                 +P++T Y    T +            + L++++  +GR HQ+R H + + HP++
Sbjct: 148 APMGEGKPSLTEYWVEDTFK-----------NFTLLKVKLHSGRTHQIRVHFSSIGHPLV 196

Query: 177 GDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           GD  +G +  +        LQR  LH   L+  + FT + + I   + D  ++  ++
Sbjct: 197 GDELYGGMAND-------ILQRQALHCFSLTFKNVFTEKMIDIKTSIPDDMLEYWNK 246


>UniRef50_C6VVP1 Pseudouridine synthase n=4 Tax=Bacteroidetes RepID=C6VVP1_DYAFD
          Length = 228

 Score =  265 bits (678), Expect = 1e-69,   Method: Composition-based stats.
 Identities = 106/236 (44%), Positives = 143/236 (60%), Gaps = 11/236 (4%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           LEILY+ + LVA+NKP+G LVHRS +  D  V  +Q +RDQ+ Q V+ AHRLDR TSGVL
Sbjct: 4   LEILYRSDDLVAINKPNGLLVHRSPIASDADVFAVQLLRDQLSQKVYPAHRLDRKTSGVL 63

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKG 121
           L  L+      +  +F + +I K YHAIVRG   +   +DYPL  +           D  
Sbjct: 64  LFALNENVNSEMQGKFMEGEITKTYHAIVRGHTADRGEIDYPLKRD-----------DGV 112

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
            Q AVTH+  LA  E+P A G++ T+RY LV+L P TGR HQLR+H+AH+ HPIIGD  H
Sbjct: 113 TQDAVTHFETLARAEVPFALGKHATSRYSLVQLNPLTGRMHQLRKHMAHIMHPIIGDRPH 172

Query: 182 GDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWR 237
           G  +QNR   E  G+ ++MLHA  +   HP +G+ +TI A     +++  S  G  
Sbjct: 173 GCNKQNRFFKEELGMIQMMLHAVSVEFVHPVSGQHVTIVAPYLSEFVRMRSVLGLE 228


>UniRef50_B0S119 Pseudouridine synthase n=2 Tax=Finegoldia magna RepID=B0S119_FINM2
          Length = 307

 Score =  265 bits (678), Expect = 1e-69,   Method: Composition-based stats.
 Identities = 56/238 (23%), Positives = 104/238 (43%), Gaps = 25/238 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHV------FTAHRLDR 55
           L+++Y+D++L  +NK    +VH +     + +V       +    V         HRLD+
Sbjct: 77  LDVVYEDDYLAIINKDKDVIVHPTETIYSDTLVNYLMYNFKNLSDVDGDYRRGIVHRLDK 136

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKF 115
            T+G++++   ++    L +  + H+I K Y  IV G + E   +   +           
Sbjct: 137 DTTGLIIIAKDNDTHLKLKEIIKNHEIIKTYLCIVHGKIDESGTIKEYMTRNPKDRKKMM 196

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
             ++   + +++ Y  L                Y LV+++ KTGR HQ+R H+ ++ HPI
Sbjct: 197 VSDE--GKLSISQYERLDY-----------NDDYSLVKVQIKTGRTHQIRVHMNYIHHPI 243

Query: 176 IGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           +GD  +G  +      E       +LHA  L   HP T E + +   L   +M A+ +
Sbjct: 244 LGDKLYGLKK------EKILFDSQVLHAYNLQFIHPQTHEKINVIGKLKPDFMTAIEK 295


>UniRef50_D0L1K7 Pseudouridine synthase n=1 Tax=Halothiobacillus neapolitanus c2
           RepID=D0L1K7_HALNC
          Length = 346

 Score =  265 bits (678), Expect = 1e-69,   Method: Composition-based stats.
 Identities = 76/240 (31%), Positives = 116/240 (48%), Gaps = 19/240 (7%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLM 63
           I+Y+DE L+AVNKP+G  VH         + +M+     +G+ +  AHR+DR TSG+L++
Sbjct: 111 IVYEDEALLAVNKPAGLAVHGGSNIPFGLIELMR-QHTGLGEKLELAHRIDRDTSGLLIL 169

Query: 64  GLSSEAGRLLAQQFE-QHQIQKRYHAIVRGWLMEE-AVLDYPLVEELDKIADKFAREDKG 121
             +      L  QF  +   +K+Y AIV G   ++   +D PL +   +      + +  
Sbjct: 170 AKTRATLHSLQTQFRPEGHAEKQYLAIVHGHWPDKLKRVDAPLEKWQGEGESHRVQVNPQ 229

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
            + AVTH+  LA                 L+  + +TGR HQ+R H AH  HPI+GD K+
Sbjct: 230 GKEAVTHFAVLA-----------ANKNATLLRAQLETGRTHQIRVHTAHENHPIVGDEKY 278

Query: 182 GDLRQNRSGAEHFGL-----QRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGW 236
           G    ++      G        L+LHA +L LTHP T +PL + A + D W     Q   
Sbjct: 279 GQREWDKRLFPSTGASARRRPPLLLHAYRLMLTHPQTEQPLQLTAPIPDKWRSLAQQLNL 338


>UniRef50_B1H0R5 Pseudouridine synthase n=1 Tax=uncultured Termite group 1 bacterium
           phylotype Rs-D17 RepID=B1H0R5_UNCTG
          Length = 296

 Score =  264 bits (677), Expect = 1e-69,   Method: Composition-based stats.
 Identities = 55/222 (24%), Positives = 99/222 (44%), Gaps = 17/222 (7%)

Query: 12  VAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLMGLSSEAGR 71
           V VNK SG +VH S+      ++           + +  HRLD+ TSGV++   + +A  
Sbjct: 88  VVVNKRSGIVVHPSYGHLSGTLLNALMGYSAGKYNPYLIHRLDKDTSGVIVFAKTEKAKI 147

Query: 72  LLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADKFAREDKGPQPAVTHYR 130
            +++Q ++  ++K Y+A V+G + E   ++  PL                  + A+T ++
Sbjct: 148 SISKQLQKRVVKKIYYAAVKGVIAENRGIIKAPLGRSPKNRKLVSVNPLAK-KVAITEFK 206

Query: 131 GLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHGDLRQNRSG 190
            +                Y L+++   TGR HQ+R H+ ++ HP+IGD ++G        
Sbjct: 207 VIER-----------KDDYTLLKVRIITGRTHQIRSHMKYINHPVIGDKQYGGPGTIGLK 255

Query: 191 AEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALS 232
                 +R MLHA  ++ THP T + +   A L +       
Sbjct: 256 R----CERQMLHAHNITFTHPSTSKTVKFIAQLPNDMKAIFK 293


>UniRef50_Q63E77 Pseudouridine synthase n=73 Tax=Bacillaceae RepID=Q63E77_BACCZ
          Length = 307

 Score =  264 bits (677), Expect = 1e-69,   Method: Composition-based stats.
 Identities = 51/238 (21%), Positives = 101/238 (42%), Gaps = 23/238 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQ---IGQHVFTAHRLDRPTS 58
           L ++Y+D+ ++ VNKP     H S       +  +     Q   +   V   HRLD+ T+
Sbjct: 85  LHVVYEDDHVLIVNKPEKMDTHPSEKGGMGTLANLVAFHFQMQGLETKVRHIHRLDKDTT 144

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADKFAR 117
           G ++      AG ++ +   + +I++ Y A+V G + + +  +D  +  +      +   
Sbjct: 145 GGVVFAKHRIAGAIMDRLLMERKIKRTYAALVEGKVKKKQGTIDAAIGRDRHHATRRRV- 203

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
                  A+T+Y+     +              LV L+ +TGR HQ+R H+++  +P++G
Sbjct: 204 -SPKGDQAITYYKVEEYFK---------KQNVTLVTLQLETGRTHQIRVHMSYNGNPLVG 253

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFG 235
           D  +G   +         + R  LHA +++  HP T E + +           +  F 
Sbjct: 254 DVLYGGGTK--------YMSRQALHAMKINFLHPITKEEIEVDVPFPTKLNDTMKAFQ 303


>UniRef50_A9BZ16 Pseudouridine synthase n=9 Tax=Burkholderiales RepID=A9BZ16_DELAS
          Length = 319

 Score =  264 bits (677), Expect = 1e-69,   Method: Composition-based stats.
 Identities = 124/270 (45%), Positives = 157/270 (58%), Gaps = 18/270 (6%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           L IL++DE LVAV KP+GWLVHR+ LD  E   V+QT+RDQ+G HV+ AHRLD+ T GVL
Sbjct: 51  LHILWRDEHLVAVYKPAGWLVHRTGLDAHETRFVLQTLRDQLGCHVYPAHRLDKGTCGVL 110

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKG 121
           +M L ++A + L Q F   +++K+Y A+VRGWL +   +D+ L  +        A ED  
Sbjct: 111 VMALHAQAAQRLGQAFAGQEVRKQYLALVRGWLPDAVEVDHALRPDD-------APEDAP 163

Query: 122 PQPAVTHYRGLATVEMPVA-TGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSK 180
            QPA T  R LA +E P A   R+  TR  LVE  P TGR+HQ+RRHL H+ HPIIGD+ 
Sbjct: 164 AQPAQTSLRCLARLEWPEAFDPRHAATRISLVEALPATGRRHQIRRHLKHVAHPIIGDAT 223

Query: 181 HGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGL--------DDTWMQALS 232
           HG    NR  AE  GLQRL LHA  L L HP TGEPL   A             W    +
Sbjct: 224 HGKGPLNRWWAERLGLQRLWLHAHALELAHPMTGEPLRFEADWRQLGHVADVQHWRALCA 283

Query: 233 QFGWRGL--LPENERVEFSAPSGQDGEISS 260
             GW+    LP   R + +A +G  G   S
Sbjct: 284 LPGWQACAGLPATARPDQTASAGAPGSGCS 313


>UniRef50_A8Z5T0 Pseudouridine synthase n=3 Tax=Candidatus Sulcia muelleri
           RepID=A8Z5T0_SULMW
          Length = 337

 Score =  264 bits (677), Expect = 1e-69,   Method: Composition-based stats.
 Identities = 48/246 (19%), Positives = 100/246 (40%), Gaps = 22/246 (8%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVF-----TAHRLDRP 56
           + I Y+DE+++ +NK SG +VH    +    ++          ++++       HR+D+ 
Sbjct: 101 INIFYEDEYVIIINKQSGLVVHPGKGNESMTLINGLHFYFLKKKNIYNKIPILVHRIDKG 160

Query: 57  TSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADKF 115
           TSG++L+         + +QF  + I+++Y  +V G++   +  +   +   L       
Sbjct: 161 TSGLILVAKDKNILEKIYKQFYINHIKRKYITLVWGYIKNNKGTIICNIGRSLKNRIYMN 220

Query: 116 AREDK-GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHP 174
              +    + ++THY+ L   +              L++   +TGR HQ+R HL ++ HP
Sbjct: 221 VFPNGIYGKFSITHYKVLERFKY-----------VTLLKCTLETGRTHQIRVHLKYIGHP 269

Query: 175 IIGDSKHGDLRQNRSGAE----HFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQA 230
           I+ D  +G     +           ++   LHA  +   HP   +       + D     
Sbjct: 270 ILNDKDYGGNHTFKEKKNIKKLFINMKYQALHAYYIEYIHPIYRKKNYFICPIPDRIKFL 329

Query: 231 LSQFGW 236
           +     
Sbjct: 330 IKNLRL 335


>UniRef50_A7I2U9 Pseudouridine synthase n=23 Tax=Campylobacterales
           RepID=A7I2U9_CAMHC
          Length = 357

 Score =  264 bits (677), Expect = 1e-69,   Method: Composition-based stats.
 Identities = 60/250 (24%), Positives = 106/250 (42%), Gaps = 22/250 (8%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQ------IGQHVFTAHRLDR 55
           +EILY+D+ L+ +NKPSG +VH +   ++  +      +          +     HRLD+
Sbjct: 90  IEILYEDDDLLVLNKPSGVVVHPAKSVKEPTLAEWLKQKKYMLSSINGDERAGIVHRLDK 149

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKF 115
            TSG +L+  +  A   LA Q +   + + Y A +   L E   +D  +         K 
Sbjct: 150 QTSGAILVAKTDFAHVKLAAQLKDKSMGRIYLAFLDLALKENVCVDRFIARNPSNRLKKA 209

Query: 116 ARE--DKGPQPAVTHY------RGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRH 167
                + G + A + +        L   +          T + L+  +  TGR HQ+R H
Sbjct: 210 VVPPNENGARSAKSAFLNIANDTILQNFK--PLNFSQNQTNFNLIAAKLFTGRTHQIRVH 267

Query: 168 LAHLRHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTW 227
           L+ +   IIGD  +G        ++   ++R+ LHA  L  THP T   + I A +   +
Sbjct: 268 LSSINRHIIGDFLYG------FKSDFDKIKRIFLHAYLLYFTHPRTNRQILISAKIPSEF 321

Query: 228 MQALSQFGWR 237
              + +  ++
Sbjct: 322 KNLIEKSDFK 331


>UniRef50_C4ZAQ6 Pseudouridine synthase n=15 Tax=Clostridiales RepID=C4ZAQ6_EUBR3
          Length = 295

 Score =  264 bits (677), Expect = 2e-69,   Method: Composition-based stats.
 Identities = 53/233 (22%), Positives = 97/233 (41%), Gaps = 21/233 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFT---AHRLDRPTS 58
           L+I Y+D+ ++ +NKP     H S  + D  +              F     +RLDR T+
Sbjct: 81  LDIAYEDDDIIVINKPFDMPAHPSAGNHDNTLANALMYYYGSQNKPFVYRCINRLDRDTT 140

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           G+ ++   + AG +L     +  I + Y+A+  G       +  P+  +     ++    
Sbjct: 141 GLTIVAKHALAGGILGNAVAKRAIHRTYYAVCSGCTPACMRISAPIARKDASTIERCVDF 200

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
            K  + AVT +  +            P     LV+L   TGR HQ+R H+ ++  P+IGD
Sbjct: 201 -KRGEYAVTDFIRIKY---------NPDNNLSLVKLRLLTGRTHQIRVHMKYIGFPLIGD 250

Query: 179 SKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
             +          ++  + R  LH+ +L  THP TG+ + + + +        
Sbjct: 251 FLY--------NPDYTYISRQALHSGRLVFTHPVTGQKMNLISDIPSDMKSLF 295


>UniRef50_A4FXG9 Pseudouridine synthase, RluA family n=5 Tax=Methanococcus
           RepID=A4FXG9_METM5
          Length = 298

 Score =  264 bits (677), Expect = 2e-69,   Method: Composition-based stats.
 Identities = 56/238 (23%), Positives = 108/238 (45%), Gaps = 26/238 (10%)

Query: 1   MLEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQ---HVFTAHRLDRPT 57
           +L ++Y+D+ L+ V+KP   +VH +       +    +   +I      +   +RLD  T
Sbjct: 81  LLCVIYEDDDLLIVDKPKNMVVHPTKNVLSGTLANAISNHQKINNQNYKIRFVNRLDMDT 140

Query: 58  SGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADKFA 116
           +G+L++  +S + + LA+Q ++  ++K Y  +V G L  +E V++  +    D I  + +
Sbjct: 141 TGLLIIAKNSYSHQQLAKQMDEGILEKIYIVVVNGHLDSKEGVIEDSIDLNDDGIKRELS 200

Query: 117 REDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPII 176
                 + + T Y+ +                  ++E++  TGR HQ+R HL+   + II
Sbjct: 201 TF---GKISKTKYKVIEEF-----------NNVSVLEIKLLTGRTHQIRVHLSSFGNNII 246

Query: 177 GDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           GD+ +G             ++R  LH+  L   HP T E + I + L D     +   
Sbjct: 247 GDTLYGKTAD--------LIERQALHSHILRFIHPITKENMEIRSKLPDDMENLIKNL 296


>UniRef50_B9DS29 Pseudouridine synthase n=85 Tax=Firmicutes RepID=B9DS29_STRU0
          Length = 301

 Score =  264 bits (677), Expect = 2e-69,   Method: Composition-based stats.
 Identities = 63/241 (26%), Positives = 104/241 (43%), Gaps = 28/241 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVV----MQTVRDQIGQHVFTAHRLDRPT 57
           L+I+Y+D+  + +NKP G+    S +     +          ++   + V    RLDR T
Sbjct: 76  LDIVYEDDHFLVLNKPVGYASIPSAIH-SNTIANFIKAYYFEQNYPNKQVHIVTRLDRDT 134

Query: 58  SGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGW--LMEEAVLDYPLVEELDKIADKF 115
           SG++L      A   L +Q ++  I+KRY A+V G   L +   +  P+    D I  + 
Sbjct: 135 SGLMLFAKHGYAHARLDKQLQKRSIEKRYFALVSGNGQLPDFGEIVEPIGRSKDSIITRT 194

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
              D   + A T Y  +A     V           LV+++  TGR HQ+R H +H+  P+
Sbjct: 195 V--DPMGKYAKTTYEVVARFAENVH----------LVDIKLHTGRTHQIRVHFSHIGFPL 242

Query: 176 IGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFT-GEPLTIHAGLDDTWMQALSQF 234
           +GD  +G            G++R  LH   LS  +PFT  E +     L + +   +   
Sbjct: 243 LGDDLYGGR-------MDLGIERQALHCHFLSFFNPFTENESIH-TINLTEDFENVIIDL 294

Query: 235 G 235
            
Sbjct: 295 Q 295


>UniRef50_Q83G23 Pseudouridine synthase n=2 Tax=Tropheryma whipplei
           RepID=Q83G23_TROWT
          Length = 303

 Score =  264 bits (677), Expect = 2e-69,   Method: Composition-based stats.
 Identities = 66/238 (27%), Positives = 105/238 (44%), Gaps = 20/238 (8%)

Query: 1   MLEILYQDEWLVAVNKPSGWLVHRSWLDRDEKV---VVMQTVRDQIGQHVFTAHRLDRPT 57
           +L ++Y D+ L  ++KP+G   H S       V   +                HRLD  T
Sbjct: 75  LLRVIYSDDDLFVIDKPAGVAAHASPGWCGPTVTGCLSGLLAACGPQDRQGIVHRLDANT 134

Query: 58  SGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADKFA 116
           SG++++  S  A   L   F    I KRY A+V+G+      V++ P+  +L        
Sbjct: 135 SGLMVLAKSDLAYHNLKAAFRDRAIHKRYKALVQGYPDPSSGVINAPIGRDLKHRDRFCI 194

Query: 117 REDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPII 176
             D   + AVT Y                   + L+ + PKTGR HQ+R H + LRHP++
Sbjct: 195 --DYSGRDAVTQYSTEEVYP-----------GFTLLSVAPKTGRTHQIRVHFSALRHPLV 241

Query: 177 GDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           GD K+G    +   ++   L+R  LHA  LS THP +G  +   + + +   ++L   
Sbjct: 242 GDVKYG---ADPVFSQKVNLKRQWLHAYHLSFTHPVSGVFVEFESRIHEDLQESLRIL 296


>UniRef50_B8I750 Pseudouridine synthase, RluA family n=2 Tax=Clostridium
           RepID=B8I750_CLOCE
          Length = 299

 Score =  264 bits (676), Expect = 2e-69,   Method: Composition-based stats.
 Identities = 59/237 (24%), Positives = 104/237 (43%), Gaps = 22/237 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVV---MQTVRDQIGQHVFTAHRLDRPTS 58
           L+++Y+DE ++ +NK SG +VH +    D  +         +  + + V    RLDR TS
Sbjct: 79  LDVIYEDECMLVLNKQSGIVVHPTSYHPDNTIANGIVYYLKQKGVTKKVRPVSRLDRETS 138

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADKFAR 117
           G+++   +     +L QQ   +  +K Y  IV+G     E  ++ P+  +   I  +   
Sbjct: 139 GIIIFAKNQFTQEMLIQQMHNNLFKKEYLGIVQGIPQNNEGTINLPIARKPGSIMLRHI- 197

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
             +   P++THY+ L T          P+    L+  + +TGR HQ+R H   +  PI G
Sbjct: 198 -SEEGAPSITHYKILKTF---------PSHNSALLSFKLETGRTHQIRVHCKAMGFPIYG 247

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           D+ + D         +  + R  LH+ +  + HP T + +   A L       L   
Sbjct: 248 DTLYSDN-------TNLFISRQALHSYRTEIIHPVTLKGVIFKAELPSDISGLLEIL 297


>UniRef50_Q1WS43 Pseudouridine synthase n=3 Tax=Lactobacillus RepID=Q1WS43_LACS1
          Length = 296

 Score =  264 bits (676), Expect = 2e-69,   Method: Composition-based stats.
 Identities = 62/238 (26%), Positives = 100/238 (42%), Gaps = 25/238 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVR-DQIGQH---VFTAHRLDRPT 57
           L+I+Y+D   + V+KP          +R + +V        Q            RLDR T
Sbjct: 77  LDIIYEDSNWLVVDKPPLLSSVPGPSNRTDTLVNRVKFHLWQQKSKDLVPHVITRLDRDT 136

Query: 58  SGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADKFA 116
           SG++L+     A  L+ +Q E+H I K+Y A+V G +  +  ++D PL    + I     
Sbjct: 137 SGLVLVAKHRFAQGLINKQVEEHSIDKKYLAVVEGIITEKHGIIDKPLGPRENGIGQMVT 196

Query: 117 REDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPII 176
                 + A T Y     +            +  LVE +  TGR HQ+R H + + H ++
Sbjct: 197 D---TGKIAKTEYWVREYL----------GDKATLVECKLHTGRTHQIRAHFSSINHALV 243

Query: 177 GDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           GD  +G           +GL+R  LHA QL+   PFT E     + +       + + 
Sbjct: 244 GDELYGGR-------LDWGLERQALHAYQLAYVDPFTQEEKLFKSEMPKDLENLIVRL 294


>UniRef50_B5ZBC1 RluA n=15 Tax=Ureaplasma RepID=B5ZBC1_UREU1
          Length = 299

 Score =  264 bits (676), Expect = 2e-69,   Method: Composition-based stats.
 Identities = 57/236 (24%), Positives = 103/236 (43%), Gaps = 22/236 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           LEI+++D+ L+ +NKPSG LVH +       +        +     +  HRLD+ TSG++
Sbjct: 79  LEIVFEDQDLLVINKPSGMLVHPTSFQEQNTLANALKHYLKTDDF-YITHRLDKNTSGLI 137

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEA---VLDYPLVEELDKIADKFARE 118
           ++  + +A   L QQF Q  ++K Y+AIV           +++ P+             +
Sbjct: 138 VICKNQKALCCLQQQFMQKTVKKSYYAIVHNRFDMHHLHFMINEPIGHSYQDKLRMKTGD 197

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
            K  + A++  + +                  LVE+   TGR HQ+R H+ H+ HPI  D
Sbjct: 198 AKNVKEAISIVKVIEQY-----------QNTALVEVSIITGRTHQIRVHMRHINHPIYND 246

Query: 179 SKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
             +G  +               LH+  +S  HP T E +     + + ++  + ++
Sbjct: 247 PLYGISKHTTPYE-------QYLHSFYISFIHPSTNEIVEFKTLMPNEFINLIKEW 295


>UniRef50_Q057H9 Pseudouridine synthase n=1 Tax=Buchnera aphidicola str. Cc (Cinara
           cedri) RepID=Q057H9_BUCCC
          Length = 321

 Score =  264 bits (675), Expect = 3e-69,   Method: Composition-based stats.
 Identities = 50/244 (20%), Positives = 102/244 (41%), Gaps = 23/244 (9%)

Query: 1   MLEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIG---QHVFTAHRLDRPT 57
            L I+++D  ++ +NKP+ ++VH  + +    ++                   HRLDR T
Sbjct: 85  FLNIIFEDSEILIINKPTNFVVHLGYGNTSGTLLNALIFHYPDNLLIPRAGIVHRLDRNT 144

Query: 58  SGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAR 117
           +G+L++  +      L   F++ +I K Y  IV G +  +  ++ P+  ++         
Sbjct: 145 TGILVVAKTISTYYFLINLFKKRKIIKEYDVIVIGRIEVDGKIEKPIKRDIYNRTKMTV- 203

Query: 118 EDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIG 177
              G + A+T+Y  +   +            +  + ++ KTGR HQ+R HL+ + HP++G
Sbjct: 204 -GIGGKQAITYYSVITIFK-----------NHTYLRIQLKTGRMHQIRVHLSSIFHPVLG 251

Query: 178 DSKHGDLRQNRSGAEHFGLQ-------RLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQA 230
           D  +    ++        ++       R  LHA  L+  HP T +            +  
Sbjct: 252 DKIYSKGIKSNFSNCSKKMKNFLSKFNRPALHARMLNFIHPKTNKKKNWIIYPPKDMLSL 311

Query: 231 LSQF 234
           ++  
Sbjct: 312 INVL 315


>UniRef50_Q38W13 Pseudouridine synthase n=4 Tax=Lactobacillus RepID=Q38W13_LACSS
          Length = 300

 Score =  263 bits (674), Expect = 4e-69,   Method: Composition-based stats.
 Identities = 66/235 (28%), Positives = 102/235 (43%), Gaps = 26/235 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQH----VFTAHRLDRPT 57
           +++LY+D++ + VNKP+G        +  + ++       Q             RLD  T
Sbjct: 79  IKVLYEDDYWLVVNKPAGLATIPGPTNTTDTLLNRIKGYWQQNGATDLVPHIITRLDFDT 138

Query: 58  SGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGW-LMEEAVLDYPLVEELDKIADKFA 116
           SG++L      A  LL  Q EQHQ+QK Y A+V G  L E   +  P+     +   +  
Sbjct: 139 SGIVLAAKHQVAQSLLQPQIEQHQLQKFYLAVVAGTGLPEFGTIKAPIGRVGVEPRRRVI 198

Query: 117 REDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPII 176
                 Q A T Y  LA  E           R  +++++  TGR HQ+R HL+ L HP++
Sbjct: 199 ---ADGQSAWTDYWRLAQDE-----------RLTVLKVQIHTGRTHQIRVHLSDLDHPLV 244

Query: 177 GDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
           GD  +        G   +G+ R  LHA QL+   PF+ +     A +       L
Sbjct: 245 GDQLY-------EGPLGWGIDRQALHAYQLTFNDPFSQQKRQFTAPIPADIQAIL 292


>UniRef50_Q2IJ40 Pseudouridine synthase n=7 Tax=Cystobacterineae RepID=Q2IJ40_ANADE
          Length = 353

 Score =  263 bits (674), Expect = 4e-69,   Method: Composition-based stats.
 Identities = 65/263 (24%), Positives = 99/263 (37%), Gaps = 27/263 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVR---------DQIGQHVFTAHR 52
           L +L++D  L+ ++K  G +VH +       VV     R         D     +   HR
Sbjct: 100 LAVLHEDADLIVLDKAPGMVVHPARGTPHSTVVNALLHRLGLPAAAGPDGALPRLGLVHR 159

Query: 53  LDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIA 112
           LD+ TSG L++  +  A   L  Q++   ++K Y A+  G L     LD P         
Sbjct: 160 LDKDTSGCLVVAKTEAALAALQAQWKGRSVEKVYLALCHGALAAAGRLDTPYGRHPRDRL 219

Query: 113 DKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLR 172
               R     + A+T +R                    L E+   TGR HQ+R HL+   
Sbjct: 220 RFTGRL-ASSRRAITEWRVREAF----------GPAASLAEVTLHTGRTHQIRVHLSEAG 268

Query: 173 HPIIGDSKHGDLR-------QNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDD 225
           HP++GD+ +G  R        + +      + R  LHA +L L HP TG  L + A +  
Sbjct: 269 HPLLGDAVYGGTRREARLAPDDPARRAAEAVGRQALHALRLGLDHPRTGRRLVVEAPVPA 328

Query: 226 TWMQALSQFGWRGLLPENERVEF 248
               AL                 
Sbjct: 329 DLRAALEILRAAQPGNAGPAPRR 351


>UniRef50_A4BJ00 Pseudouridine synthase n=1 Tax=Reinekea blandensis MED297
           RepID=A4BJ00_9GAMM
          Length = 249

 Score =  263 bits (673), Expect = 5e-69,   Method: Composition-based stats.
 Identities = 107/243 (44%), Positives = 144/243 (59%), Gaps = 5/243 (2%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVM-----QTVRDQIGQHVFTAHRLDRP 56
           L I+Y+D+ L+ V+KPSG L+H SWLDR E   +         +   G  V T HRLDRP
Sbjct: 4   LNIVYEDDVLLVVDKPSGLLMHPSWLDRRETDTLAGRAKAYLAQQSEGAKVHTVHRLDRP 63

Query: 57  TSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFA 116
           TSG+++M     A + L +QF++  + KRY AI RG+      LDYPL+EE D+IADKFA
Sbjct: 64  TSGLVVMCKDDHAAKALVEQFQEKTVNKRYWAICRGFAPVAETLDYPLIEEHDRIADKFA 123

Query: 117 REDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPII 176
             DK  Q A+T +R L   E+ +   RYP  R   +E  P TGRKHQ+RRHL HLR+PI+
Sbjct: 124 DSDKPAQEAITEFRRLGITELAIPVSRYPKMRLSWMECVPVTGRKHQIRRHLKHLRYPIL 183

Query: 177 GDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGW 236
           GD++HG    NR+    FG   + L A ++S  HP T E +T + G D+ W   L + GW
Sbjct: 184 GDTRHGCRHLNRAVEGSFGELFMGLRAVEMSFQHPVTNELMTFNVGADNVWSCWLDRLGW 243

Query: 237 RGL 239
              
Sbjct: 244 SFP 246


>UniRef50_D0BL50 Pseudouridine synthase n=1 Tax=Granulicatella elegans ATCC 700633
           RepID=D0BL50_9LACT
          Length = 296

 Score =  262 bits (672), Expect = 6e-69,   Method: Composition-based stats.
 Identities = 70/238 (29%), Positives = 106/238 (44%), Gaps = 26/238 (10%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQH----VFTAHRLDRPT 57
           L+IL++D++L+ VNKP G     S L  D+ +        Q  +          RLDR T
Sbjct: 77  LDILFEDDYLLIVNKPQGTASIPSQLHPDQSMANRVKGYLQTTRTQDCVTHVVTRLDRDT 136

Query: 58  SGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIV--RGWLMEEAVLDYPLVEELDKIADKF 115
           +GV++          + Q      IQK YHAIV  +  L E  ++D P+    D I ++ 
Sbjct: 137 TGVMMFAKHRVVHAWMDQALRNKTIQKTYHAIVTKQDVLKEHDLIDAPIGRTDDSIINRC 196

Query: 116 AREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPI 175
            R D   +P++T Y    T +              LV++   TGR HQ+R H + L  P+
Sbjct: 197 VRPD--GKPSLTEYWLEETYQHSQ-----------LVKIRLHTGRTHQIRVHFSWLGCPL 243

Query: 176 IGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQ 233
           +GD  +G  +          L R  LH SQL   HP TGE + + A L     + + +
Sbjct: 244 LGDDLYGGEKIEP-------LMRQALHCSQLDFVHPMTGEKMCVKALLPKDMAEWIEK 294


>UniRef50_C1ZB48 Pseudouridine synthase, RluA family n=1 Tax=Planctomyces
           limnophilus DSM 3776 RepID=C1ZB48_PLALI
          Length = 325

 Score =  262 bits (672), Expect = 6e-69,   Method: Composition-based stats.
 Identities = 74/252 (29%), Positives = 111/252 (44%), Gaps = 28/252 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVR------DQIGQHVFTAHRLDR 55
           LEIL++D+ L+ +NKP+G + H +    D  ++                +     HRLDR
Sbjct: 82  LEILFEDDSLLVINKPAGLIAHPTGEIPDGTLINAVQHYLDKQSTHPGLERPGIVHRLDR 141

Query: 56  PTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEA-VLDYPLVEELD-KIAD 113
            TSG + +     + RLL+ QF+  +I K Y A+V G L ++  V+D P+        A 
Sbjct: 142 DTSGAMAICKEHLSHRLLSIQFQLGRISKSYLALVEGVLTDDQLVIDLPIGRAPGCSSAL 201

Query: 114 KFAREDK-GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLR 172
              R D    Q + T  R +               ++ LVE +P+TGR HQ+R HLA + 
Sbjct: 202 MSCRADALEAQASKTSLRVVERFP-----------QHTLVEAKPRTGRMHQIRIHLATIG 250

Query: 173 HPIIGDSKH--GDL------RQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLD 224
            PI+GD  +  G         ++        + R  LHA+ LS  HP T E     A L 
Sbjct: 251 FPIVGDEFYLKGGEIRPLVWPESERVQVSLLINRQALHAACLSFAHPLTNEWQDFQAPLP 310

Query: 225 DTWMQALSQFGW 236
           D   QA+     
Sbjct: 311 DDLRQAIELARL 322


>UniRef50_B4RVP9 Pseudouridine synthase n=1 Tax=Alteromonas macleodii 'Deep ecotype'
           RepID=B4RVP9_ALTMD
          Length = 265

 Score =  262 bits (671), Expect = 8e-69,   Method: Composition-based stats.
 Identities = 115/233 (49%), Positives = 150/233 (64%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           L +LYQDE ++A++KP G LVHRS +D+ E V  +QT+RDQIGQHVF AHRLDRPTSGVL
Sbjct: 28  LPVLYQDEHIIAIDKPPGLLVHRSPIDKHETVFAVQTLRDQIGQHVFPAHRLDRPTSGVL 87

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKG 121
           +   S++    L +Q    Q+ K+YHAIVRG++     +DY L    DKIADK  R  + 
Sbjct: 88  VFSFSADTAAKLGKQMMDKQVVKQYHAIVRGFVHHTGYIDYALKYRYDKIADKHKRPQQP 147

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
           PQPA T Y  LA  ++P   GRY + RY LV L P TGRKHQLRRH+ H+RHPIIGD+ H
Sbjct: 148 PQPASTMYESLAKFDVPEPVGRYQSARYSLVRLSPSTGRKHQLRRHMVHIRHPIIGDTTH 207

Query: 182 GDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQF 234
           GD +QN+    HF    L L  +Q+  +HP T + +TI+  +     Q   + 
Sbjct: 208 GDGKQNKFAKSHFNFTHLALSCTQMGFSHPVTQKWITINGEMHSEMRQFTDRL 260


>UniRef50_A9GBV3 Pseudouridine synthase n=1 Tax=Sorangium cellulosum 'So ce 56'
           RepID=A9GBV3_SORC5
          Length = 345

 Score =  262 bits (671), Expect = 9e-69,   Method: Composition-based stats.
 Identities = 67/260 (25%), Positives = 104/260 (40%), Gaps = 35/260 (13%)

Query: 1   MLEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTV-----------RDQIGQ-HVF 48
           ++ ++Y+DE L+ ++KP+G +VH +       +V                RD +G     
Sbjct: 90  VIPVVYEDEHLLVIDKPAGLVVHPARGHASGTLVNGLLALPGFALAPADPRDPMGHVRPG 149

Query: 49  TAHRLDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEEL 108
             HRLDR TSG+L++         L  +F +H I++ Y AIV G    +A  D       
Sbjct: 150 IVHRLDRGTSGLLVVAKDEPTREALKDRFARHAIEREYAAIVAGE-ARDATYDTLHGRHP 208

Query: 109 DKIADKFAREDKGP----------QPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKT 158
                  +    G           + AVTH R +  +               +V    +T
Sbjct: 209 TDRLRFTSWIRGGAGAPGSHVAAPRRAVTHVRVIERL----------GDAATVVACSLET 258

Query: 159 GRKHQLRRHLAHLR-HPIIGDSKHGDLRQNRSGAE-HFGLQRLMLHASQLSLTHPFTGEP 216
           GR HQ+R HLA     P++GD  +G   +  +       L R  LHA  L   HP T +P
Sbjct: 259 GRTHQIRVHLAERGRTPVLGDPLYGKPPKKPAVRAIAEELGRQALHARVLGFIHPATQKP 318

Query: 217 LTIHAGLDDTWMQALSQFGW 236
           +   + L     +AL Q   
Sbjct: 319 VRWESALPADMRKALDQLRA 338


>UniRef50_Q1N5G6 Pseudouridine synthase n=1 Tax=Bermanella marisrubri
           RepID=Q1N5G6_9GAMM
          Length = 236

 Score =  262 bits (671), Expect = 9e-69,   Method: Composition-based stats.
 Identities = 110/234 (47%), Positives = 144/234 (61%), Gaps = 7/234 (2%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVLLM 63
           ILYQD+ L+A+NKPSG LVH+SW+ +D K   +Q VRD  G+HVF  HRLDRPTSGVLL 
Sbjct: 9   ILYQDDDLIAINKPSGLLVHKSWVAKDAKEFALQIVRDMSGKHVFPVHRLDRPTSGVLLF 68

Query: 64  GLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKGPQ 123
           G S E  + +  Q+E  Q  K Y A+VRGWL E+ ++D+ L    D   D         Q
Sbjct: 69  GFSGEIAQQVQAQWE--QANKTYWAVVRGWLKEQTLVDHALKGMADYGQDVEIV-----Q 121

Query: 124 PAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKHGD 183
            A TH++ +  VE+     RYP +R+  VE +PK GR HQ+RRHL HL HPIIGD+++G 
Sbjct: 122 EAQTHFKPIDYVEIDAEIDRYPKSRFSWVEAKPKQGRTHQIRRHLKHLSHPIIGDARYGK 181

Query: 184 LRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALSQFGWR 237
            + NR   EH+   RL+LH  QL +THP +G  L I A L+       S F W+
Sbjct: 182 GKYNRYITEHYDCPRLLLHHQQLEMTHPVSGSKLMITAPLEGAMQSLFSTFDWK 235


>UniRef50_UPI0001C37137 ribosomal large subunit pseudouridine synthase D n=1 Tax=Chlamydia
           muridarum Nigg RepID=UPI0001C37137
          Length = 338

 Score =  262 bits (670), Expect = 1e-68,   Method: Composition-based stats.
 Identities = 64/243 (26%), Positives = 104/243 (42%), Gaps = 27/243 (11%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVR---------DQIGQHVFTAHR 52
           L+ +Y+D  ++ +NKP   +VH +       VV                +        HR
Sbjct: 92  LDKVYEDNMILVINKPRNMVVHPAPGHVQGTVVHALLHEIGERLKQEFPEEPWRPGIVHR 151

Query: 53  LDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIA 112
           LD+ TSG+L+   +  A  + ++ F   Q++K Y AI      ++  +   +     K  
Sbjct: 152 LDKDTSGLLITVKTRRAKAVYSELFSSKQMKKMYIAICINSPAQK-HIHTRIARHPVKRK 210

Query: 113 DKFA--REDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAH 170
           +     ++ +G + A+TH   LA              R  +V L P+TGR HQLR H+ H
Sbjct: 211 EMTVLSKDTEGGKEAITHCHVLA-----------SNGRLSVVALYPETGRTHQLRVHMKH 259

Query: 171 LRHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQA 230
           L  PI+GD  +G    N      +GL +  LHA  L  THP + E + +   L D     
Sbjct: 260 LGTPILGDPVYGVPSINF----RYGLDKQQLHAYSLVFTHPESAERVELVTKLPDDMTSL 315

Query: 231 LSQ 233
           + +
Sbjct: 316 IEK 318


>UniRef50_B1YJB1 Pseudouridine synthase n=1 Tax=Exiguobacterium sibiricum 255-15
           RepID=B1YJB1_EXIS2
          Length = 293

 Score =  262 bits (670), Expect = 1e-68,   Method: Composition-based stats.
 Identities = 65/229 (28%), Positives = 110/229 (48%), Gaps = 22/229 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKV---VVMQTVRDQIGQHVFTAHRLDRPTS 58
           L+IL++D+WL+ VNKP G     S L  +  +   V+    + QI   +   +RLDR TS
Sbjct: 81  LDILFEDDWLLIVNKPPGMASIPSRLHPERSLSNFVLGYYRQHQIPYAIHIVNRLDRDTS 140

Query: 59  GVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFARE 118
           G+++    S A   L++  +   + +RY A++ G +  +  +D P+ +      ++  RE
Sbjct: 141 GLVVFAKHSLAHHQLSKMQQNGLLDRRYVALIEGTIPAQ-TIDLPIGQTDHSFMERMVRE 199

Query: 119 DKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGD 178
           D   Q A+TH        +        +     + ++ +TGR HQ+R HLA L HP++GD
Sbjct: 200 D--GQQAITHI-------LTSEPITAFSRELSRLTIKLETGRTHQIRVHLAALGHPLVGD 250

Query: 179 SKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTW 227
           + +              + R  LH++  +  HP TGE +T  A L D  
Sbjct: 251 TMY---------KGTPLIARQALHSASATFPHPGTGEVMTFVAPLPDDL 290


>UniRef50_B2KBB0 Pseudouridine synthase n=1 Tax=Elusimicrobium minutum Pei191
           RepID=B2KBB0_ELUMP
          Length = 299

 Score =  261 bits (669), Expect = 1e-68,   Method: Composition-based stats.
 Identities = 59/246 (23%), Positives = 102/246 (41%), Gaps = 41/246 (16%)

Query: 4   ILYQDEWLVAVNKPSGWLVHRSWLDRDE----------KVVVMQTVRDQIG-----QHVF 48
           I+++D+ +  +NKPSG LVH      +E           +V +                 
Sbjct: 77  IIFEDKNMFVINKPSGMLVHPQSPVWEENPAAAFIGEETLVSLILANPPKNFEKGITRAG 136

Query: 49  TAHRLDRPTSGVLLMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEE-AVLDYPLVEE 107
             HRLD+ TSGV+++  +S+    + + F   ++ K Y AIV G + ++  +++ P+   
Sbjct: 137 LVHRLDKDTSGVMIIAKNSKTQDAMVEMFANREMHKTYEAIVCGVVPDDKGIINVPIGRV 196

Query: 108 LDKIADKFAREDKGPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRH 167
                       +  + AVT Y  L   E              L++L P TGR +QLR H
Sbjct: 197 TGGKIK----ASELGREAVTEYSVLQRKET-----------VSLMKLHPVTGRTNQLRVH 241

Query: 168 LAHLRHPIIGDSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTW 227
           ++ L +P++GD  +          +     RLMLH+      HPFT +P+         +
Sbjct: 242 MSWLGYPVLGDWLY----------KGATAPRLMLHSKSAEFEHPFTSKPVKFTVAPPKDF 291

Query: 228 MQALSQ 233
             +   
Sbjct: 292 KDSWKN 297


>UniRef50_B5JL25 Pseudouridine synthase n=1 Tax=Verrucomicrobiae bacterium DG1235
           RepID=B5JL25_9BACT
          Length = 249

 Score =  261 bits (669), Expect = 1e-68,   Method: Composition-based stats.
 Identities = 121/231 (52%), Positives = 152/231 (65%), Gaps = 3/231 (1%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           LEILY+DE LVA++KPSG LVHRS +DR E    +Q +RDQIGQHV+ AHR+DRPTSG+L
Sbjct: 14  LEILYRDERLVAIHKPSGLLVHRSPIDRRETRFAIQLLRDQIGQHVYPAHRIDRPTSGIL 73

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKG 121
           L GL   AG  L+  F+  +IQK Y A+ RG L E  ++D PL +  D      + E   
Sbjct: 74  LFGLDEAAGTALSLLFQNREIQKNYLAVTRGHLPESGLIDSPLHKYEDADGHIKSSET-- 131

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
            Q A T YR LAT E+P  T RY TTRY LVEL P TGR+HQ+RRHLAH+RHPIIGD +H
Sbjct: 132 -QEAETAYRRLATTELPYPTERYDTTRYSLVELTPHTGRRHQIRRHLAHIRHPIIGDVRH 190

Query: 182 GDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQALS 232
           G  + N+    HF + RL+L A+ +   HPFT  PL IH   + ++  AL 
Sbjct: 191 GCNKANKLARSHFAIHRLLLAATHVVFVHPFTNAPLKIHCPPETSFQTALQ 241


>UniRef50_B7BE87 Pseudouridine synthase n=8 Tax=Bacteroidales RepID=B7BE87_9PORP
          Length = 551

 Score =  261 bits (669), Expect = 1e-68,   Method: Composition-based stats.
 Identities = 74/223 (33%), Positives = 101/223 (45%), Gaps = 21/223 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           LEI+Y+DE L+ VNKP+G L      D D     ++ +           HRLD  TSG++
Sbjct: 337 LEIVYEDESLLVVNKPAGMLSVPGKSDVDSVYQRVRRMYPG-ATGPMVVHRLDMATSGLM 395

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLME-EAVLDYPLVEELDKIADKFAREDK 120
           L+  + E  + L  QF+   + KRY A + G + E E  L+ PL  + +    +      
Sbjct: 396 LVAKTKEVHQNLQAQFKNRTVCKRYVAWLDGIVEEKEGHLELPLRPDPEDRPRQVVDVVH 455

Query: 121 GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAH---LRHPIIG 177
             +PAVT YR L            P     +V   PKTGR HQLR H AH   L  PI+G
Sbjct: 456 -GKPAVTDYRVLRYGGCKGGLRTTP----TVVSFVPKTGRTHQLRVHSAHPLGLNAPIVG 510

Query: 178 DSKHGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIH 220
           D  +G               RL LHA  L  THP +G  + + 
Sbjct: 511 DELYGKK-----------ADRLYLHAEYLGFTHPVSGVYMEVE 542


>UniRef50_Q0F3G4 Pseudouridine synthase n=1 Tax=Mariprofundus ferrooxydans PV-1
           RepID=Q0F3G4_9PROT
          Length = 315

 Score =  261 bits (668), Expect = 2e-68,   Method: Composition-based stats.
 Identities = 74/231 (32%), Positives = 114/231 (49%), Gaps = 11/231 (4%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           + +LY+D+ L+ VNKP+G +VH         +  ++  R      +  AHRLDR TSGVL
Sbjct: 94  IPVLYEDDSLLVVNKPAGMVVHGGSGHEAGLIEALKQSRGLDD--LRLAHRLDRDTSGVL 151

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWL-MEEAVLDYPLVEELDKIADKFAREDK 120
           LM    +A R L + F +  +QK Y A++ G        +   L + + +  ++   + +
Sbjct: 152 LMAKHLDALRRLTESFRERDMQKTYFALIAGHPYAHAGRMSSNLAKGVVRGGERMVVDSE 211

Query: 121 GPQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSK 180
             + +VT Y+ +   E            Y +V L P +GR HQLR  L H  HPI+GD K
Sbjct: 212 EGKASVTDYQVMIEYE-------RHGFPYAMVALNPHSGRTHQLRVQLQHEGHPILGDGK 264

Query: 181 HGDLRQNRSGAEHFGLQRLMLHASQLSLTHPFTGEPLTIHAGLDDTWMQAL 231
           +G  +   +  +  G + LMLHA +L  THP +G+ L   A   D W   L
Sbjct: 265 YG-EKAQLAAYKSLGGKGLMLHAWRLRFTHPVSGKSLECKAPWPDNWSALL 314


>UniRef50_C9M5C8 Pseudouridine synthase n=1 Tax=Jonquetella anthropi E3_33 E1
           RepID=C9M5C8_9BACT
          Length = 276

 Score =  261 bits (668), Expect = 2e-68,   Method: Composition-based stats.
 Identities = 73/242 (30%), Positives = 110/242 (45%), Gaps = 23/242 (9%)

Query: 2   LEILYQDEWLVAVNKPSGWLVHRSWLDRDEKVVVMQTVRDQIGQHVFTAHRLDRPTSGVL 61
           L++LY+ + ++ +NKP+G L        D                    HRLDR TSGV+
Sbjct: 49  LDVLYRSDSVLVINKPAGLLSQPDTKGEDSVATRALGYASDPAFGAQLVHRLDRNTSGVM 108

Query: 62  LMGLSSEAGRLLAQQFEQHQIQKRYHAIVRGWLMEEAVLDYPLVEELDKIADKFAREDKG 121
           ++ L  +A R L   F++    K Y A+V G L     +D PL+++ D    K  R    
Sbjct: 109 ILALDGQALRSLMVCFKERTANKTYLALVSGQLPPSGQIDAPLLKDPD---KKLVRVASN 165

Query: 122 PQPAVTHYRGLATVEMPVATGRYPTTRYGLVELEPKTGRKHQLRRHLAHLRHPIIGDSKH 181
            + AVT +R LAT             ++ L E+E  TGR HQ+R H+ H+ HPI+GD+K+
Sbjct: 166 GERAVTRFRRLAT-----------DGQFSLAEVEILTGRTHQIRVHMNHIGHPILGDAKY 214

Query: 182 GDLRQNRSGAEHFGLQRLMLHASQLSLTHP------FTGEPLTIHAGLDDTWMQALSQFG 235
           GD           G++R MLHA+ L +  P       +G      A L         + G
Sbjct: 215 GDFSAKPQVR-RLGIRRPMLHATCLVVNSPDDCLKEISGRR--FDAPLAADMASVCQKLG 271

Query: 236 WR 237
           + 
Sbjct: 272 FE 273


  Database: uniref50.fasta
    Posted date:  Mar 8, 2010 10:38 AM
  Number of letters in database: 1,040,396,356
  Number of sequences in database:  3,077,464
  
Lambda     K      H
   0.313    0.195    0.752 

Lambda     K      H
   0.267   0.0598    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 2,195,259,507
Number of Sequences: 3077464
Number of extensions: 125644354
Number of successful extensions: 270056
Number of sequences better than 1.0e-01: 250
Number of HSP's better than  0.1 without gapping: 2976
Number of HSP's successfully gapped in prelim test: 1038
Number of HSP's that attempted gapping in prelim test: 255707
Number of HSP's gapped (non-prelim): 4646
length of query: 260
length of database: 1,040,396,356
effective HSP length: 126
effective length of query: 134
effective length of database: 652,635,892
effective search space: 87453209528
effective search space used: 87453209528
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (20.9 bits)
S2: 93 (39.9 bits)
