BLASTP 2.2.22 [Sep-27-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= batch____ (264 letters) Database: uniref50.fasta 3,077,464 sequences; 1,040,396,356 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value UniRef50_C0ZI91 Thymidylate synthase n=24 Tax=cellular organisms... 389 e-107 UniRef50_C5BMA3 Thymidylate synthase n=8 Tax=cellular organisms ... 355 1e-96 UniRef50_Q1Q8B2 Thymidylate synthase n=702 Tax=root RepID=TYSY_P... 342 8e-93 UniRef50_Q4A611 Thymidylate synthase n=15 Tax=Mollicutes RepID=T... 320 5e-86 UniRef50_A9NG27 Thymidylate synthase n=12 Tax=cellular organisms... 315 1e-84 UniRef50_Q98Q31 Thymidylate synthase n=2 Tax=root RepID=TYSY_MYCPU 308 1e-82 UniRef50_Q27828 Thymidylate synthase n=1 Tax=Paramecium tetraure... 290 3e-77 UniRef50_B1C3H3 Thymidylate synthase n=6 Tax=Bacteria RepID=B1C3... 289 7e-77 UniRef50_P04818 Thymidylate synthase n=326 Tax=root RepID=TYSY_H... 285 1e-75 UniRef50_Q2G6V6 Thymidylate synthase n=14 Tax=Bacteria RepID=TYS... 282 9e-75 UniRef50_Q0FG99 Thymidylate synthase n=4 Tax=root RepID=Q0FG99_9... 282 1e-74 UniRef50_Q3J0W9 Thymidylate synthase n=12 Tax=Bacteria RepID=TYS... 280 2e-74 UniRef50_Q4A320 Bifunctional dihydrofolate reductase-thymidylate... 270 5e-71 UniRef50_Q4U9G5 Bifunctional dihydrofolate reductase/thymidilate... 267 2e-70 UniRef50_Q2TA32 Thymidylate synthase n=5 Tax=cellular organisms ... 265 2e-69 UniRef50_D2CLW7 Dihydrofolate reductase-thymidylate synthase n=7... 263 3e-69 UniRef50_Q27713 Thymidylate synthase n=5 Tax=Plasmodium RepID=DR... 261 2e-68 UniRef50_Q27783 Thymidylate synthase n=25 Tax=Trypanosomatidae R... 261 2e-68 UniRef50_O02604 Thymidylate synthase n=87 Tax=Plasmodium RepID=D... 258 1e-67 UniRef50_C3RUB2 Dihydrofolate reductase-thymidylate synthase n=1... 258 2e-67 UniRef50_C4Q3X9 Thymidylate synthase n=3 Tax=root RepID=C4Q3X9_S... 255 1e-66 UniRef50_A5KSZ1 Thymidylate synthase n=1 Tax=candidate division ... 254 2e-66 UniRef50_Q67JQ1 Thymidylate synthase n=1 Tax=Symbiobacterium the... 254 3e-66 UniRef50_Q04FR4 Thymidylate synthase n=279 Tax=cellular organism... 253 3e-66 UniRef50_B6AE97 Thymidylate synthase family protein n=4 Tax=cell... 253 5e-66 UniRef50_O96650 Thymidylate synthase n=17 Tax=root RepID=TYSY_ASCSU 252 8e-66 UniRef50_Q07422 Thymidylate synthase n=6 Tax=cellular organisms ... 250 4e-65 UniRef50_D2W4C0 Predicted protein n=1 Tax=Naegleria gruberi RepI... 249 5e-65 UniRef50_Q6QGJ5 Putative thymidylate synthase n=1 Tax=Enterobact... 249 7e-65 UniRef50_P00471 Thymidylate synthase n=17 Tax=T4-like viruses Re... 248 1e-64 UniRef50_Q8WYK3 Thymidylate synthase n=4 Tax=Eutheria RepID=Q8WY... 246 6e-64 UniRef50_Q9UTI7 Probable thymidylate synthase n=17 Tax=cellular ... 239 9e-62 UniRef50_Q4PBV6 Thymidylate synthase n=3 Tax=Dikarya RepID=Q4PBV... 230 4e-59 UniRef50_A2R2F6 Thymidylate synthase n=20 Tax=Leotiomyceta RepID... 226 5e-58 UniRef50_D2XB64 Bifunctional dihydrofolate reductase-thymidylate... 222 8e-57 UniRef50_Q76YC2 DTMP synthase n=1 Tax=Aeromonas phage Aeh1 RepID... 222 9e-57 UniRef50_A3QU09 Thymidylate synthase n=1 Tax=Oryctes rhinoceros ... 218 2e-55 UniRef50_UPI0001925B1E PREDICTED: similar to thymidylate synthas... 206 5e-52 UniRef50_Q5UQG3 Thymidylate synthase n=1 Tax=Acanthamoeba polyph... 203 5e-51 UniRef50_B2YFY9 Thymidylate synthase n=1 Tax=Musca domestica sal... 202 1e-50 UniRef50_A9UZA9 Thymidylate synthase n=1 Tax=Monosiga brevicolli... 199 5e-50 UniRef50_Q6WIC0 DTMP (Thymidylate) synthase n=1 Tax=Vibrio phage... 199 1e-49 UniRef50_Q88CN9 Thymidylate synthase n=74 Tax=Proteobacteria Rep... 197 3e-49 UniRef50_D1BNV6 Thymidylate synthase n=4 Tax=Veillonellaceae Rep... 192 1e-47 UniRef50_Q934U8 Putative thymidylate synthase n=1 Tax=Salmonella... 192 1e-47 UniRef50_Q8WYK4 Thymidylate synthase n=7 Tax=Fungi/Metazoa group... 192 1e-47 UniRef50_D2RRK7 Thymidylate synthase n=9 Tax=cellular organisms ... 185 2e-45 UniRef50_A6M378 Thymidylate synthase n=8 Tax=Clostridium RepID=T... 181 2e-44 UniRef50_Q65J44 Thymidylate synthase n=9 Tax=root RepID=TYSY_BACLD 179 1e-43 UniRef50_B9LR89 Thymidylate synthase n=4 Tax=Halobacteriaceae Re... 172 1e-41 UniRef50_Q7Y427 dTMP (Thymidylate) synthase n=3 Tax=unclassified... 166 9e-40 UniRef50_C5H7L6 Thymidylate synthase n=3 Tax=unclassified Myovir... 158 2e-37 UniRef50_B7C7C1 Putative uncharacterized protein n=1 Tax=Eubacte... 154 2e-36 UniRef50_A8H1B4 Thymidylate synthase n=132 Tax=root RepID=TYSY_S... 154 2e-36 UniRef50_Q6X183 Thymidylate synthase (Fragment) n=1 Tax=Enteroba... 153 7e-36 UniRef50_B3FJL1 Putative uncharacterized protein n=1 Tax=Pseudom... 151 2e-35 UniRef50_A8RRN6 Thymidylate synthase n=16 Tax=Bacteria RepID=A8R... 150 3e-35 UniRef50_B6FSV1 Putative uncharacterized protein n=1 Tax=Clostri... 147 2e-34 UniRef50_C3IV33 Thymidylate synthase n=2 Tax=Bacillus thuringien... 142 1e-32 UniRef50_B8QTX3 Putative thymidylate synthase n=1 Tax=Erwinia ph... 141 3e-32 UniRef50_A8E2Q5 Putative thymidylate synthase n=1 Tax=Enterococc... 139 7e-32 UniRef50_Q8RGP6 Thymidylate synthase n=10 Tax=Fusobacterium RepI... 139 9e-32 UniRef50_C4Z7Z1 Thymidylate synthase n=19 Tax=Bacteria RepID=C4Z... 139 1e-31 UniRef50_B9CJY5 Thymidylate synthase n=10 Tax=Bacteria RepID=B9C... 133 7e-30 UniRef50_C6JM98 Thymidylate synthase n=6 Tax=Fusobacterium RepID... 131 2e-29 UniRef50_A2SMX7 Thymidylate synthase n=1 Tax=Methylibium petrole... 128 2e-28 UniRef50_Q8MVZ9 Bifunctional dihydrofolate reductase-thymidylate... 116 6e-25 UniRef50_Q8MVZ5 Bifunctional dihydrofolate reductase-thymidylate... 111 3e-23 UniRef50_C7HUX5 Thymidylate synthase n=2 Tax=Anaerococcus RepID=... 111 3e-23 UniRef50_Q8MVZ8 Bifunctional dihydrofolate reductase-thymidylate... 106 6e-22 UniRef50_Q1ZMM6 Thymidylate synthase n=3 Tax=Gammaproteobacteria... 105 1e-21 UniRef50_Q8MW00 Bifunctional dihydrofolate reductase-thymidylate... 105 1e-21 UniRef50_Q03LN3 Thymidylate synthase n=75 Tax=Firmicutes RepID=T... 102 9e-21 UniRef50_C0ELR2 Putative uncharacterized protein n=1 Tax=Neisser... 102 1e-20 UniRef50_UPI00016AD9CB thymidylate synthase n=1 Tax=Burkholderia... 100 5e-20 UniRef50_Q8MVZ6 Bifunctional dihydrofolate reductase-thymidylate... 94 6e-18 UniRef50_B9PCT2 Predicted protein (Fragment) n=2 Tax=root RepID=... 90 8e-17 UniRef50_B2IB94 Thymidylate synthase n=2 Tax=Rhizobiales RepID=B... 83 7e-15 UniRef50_A7TUR1 Putative thymidylate synthase n=3 Tax=Streptomyc... 77 6e-13 UniRef50_Q13T72 Thymidylate synthase n=4 Tax=Burkholderiaceae Re... 75 2e-12 UniRef50_B2HI72 Thymidylate synthase, ThyA_1 n=1 Tax=Mycobacteri... 74 5e-12 UniRef50_B5S769 Putative thymidylate synthase protein n=1 Tax=Ra... 74 7e-12 UniRef50_Q03W75 Thymidylate synthase n=13 Tax=Bacteria RepID=Q03... 72 2e-11 UniRef50_C4SF99 Deoxyuridylate hydroxymethyltransferase n=1 Tax=... 67 6e-10 UniRef50_C9KVG6 Thymidylate synthase n=14 Tax=Bacteroidales RepI... 67 6e-10 UniRef50_P31654 Deoxyuridylate hydroxymethyltransferase n=2 Tax=... 67 9e-10 UniRef50_B5UXF4 Thymidylate synthase n=1 Tax=Bacillus cereus AH1... 66 1e-09 UniRef50_B0T6R4 Thymidylate synthase n=1 Tax=Caulobacter sp. K31... 66 1e-09 UniRef50_UPI00016AEAE5 thymidylate synthase n=1 Tax=Burkholderia... 65 2e-09 UniRef50_B4TEI9 Thymidylate synthase n=2 Tax=Enterobacteriaceae ... 65 3e-09 UniRef50_C7JA78 Os12g0446900 protein (Fragment) n=1 Tax=Oryza sa... 64 5e-09 UniRef50_C8S1P3 Thymidylate synthase n=1 Tax=Rhodobacter sp. SW2... 63 1e-08 UniRef50_B4Y380 MilA n=1 Tax=Streptomyces rimofaciens RepID=B4Y3... 63 1e-08 UniRef50_Q2FCV1 Thymidylate synthase n=2 Tax=Acinetobacter bauma... 62 2e-08 UniRef50_C8XUG3 Putative thymidylate synthase n=1 Tax=Shigella p... 62 3e-08 UniRef50_Q5DN81 Thymidylate synthase n=3 Tax=unclassified Siphov... 60 7e-08 UniRef50_B2ZYD3 Deoxyuridylate hydroxymethyltransferase n=1 Tax=... 58 3e-07 UniRef50_B2TJD1 Thymidylate synthase n=1 Tax=Clostridium botulin... 57 5e-07 UniRef50_Q7Y590 Putative uncharacterized protein RB69ORF048c n=3... 57 5e-07 UniRef50_Q2T5Q0 Deoxyuridylate hydroxymethyltransferase , putati... 56 1e-06 UniRef50_Q21ZJ9 Thymidylate synthase n=1 Tax=Rhodoferax ferrired... 54 4e-06 UniRef50_Q5D6W4 Thymidylate synthase-like protein n=3 Tax=Entero... 54 5e-06 UniRef50_C9DGK1 Deoxyuridylate hydroxymethyltransferase n=1 Tax=... 53 1e-05 UniRef50_Q46E28 Putative thymidylate synthase n=5 Tax=Methanosar... 53 1e-05 UniRef50_C5U4L9 Thymidylate synthase, methanogen type n=1 Tax=Me... 52 1e-05 UniRef50_UPI0001C33797 thymidylate synthase n=3 Tax=Cyanobacteri... 52 2e-05 UniRef50_Q52PP0 Putative thymidylate synthase n=1 Tax=Xanthomona... 50 7e-05 UniRef50_UPI0001742C7A thymidylate synthase n=1 Tax=candidate di... 50 9e-05 UniRef50_P18029 Deoxycytidylate 5-hydroxymethyltransferase n=10 ... 49 1e-04 UniRef50_O26868 Putative thymidylate synthase n=2 Tax=Methanothe... 49 2e-04 UniRef50_A3CSY2 Thymidylate synthase n=3 Tax=Methanomicrobiales ... 47 6e-04 UniRef50_B8GIB9 Thymidylate synthase, methanogen type n=1 Tax=Me... 47 6e-04 UniRef50_Q57931 Putative thymidylate synthase n=11 Tax=Methanoco... 47 8e-04 UniRef50_B7KFY9 Thymidylate synthase n=11 Tax=Cyanobacteria RepI... 46 0.001 UniRef50_D2BHQ5 Thymidylate synthase n=5 Tax=Dehalococcoides Rep... 40 0.061 >UniRef50_C0ZI91 Thymidylate synthase n=24 Tax=cellular organisms RepID=TYSY_BREBN Length = 264 Score = 389 bits (1000), Expect = e-107, Method: Compositional matrix adjust. Identities = 179/264 (67%), Positives = 215/264 (81%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL 60 MKQYL+L Q++LDEG K DRTGTGT S+FGHQMRF+L +GFP+VTTK+ H++SIIHELL Sbjct: 1 MKQYLDLCQRILDEGVIKEDRTGTGTTSVFGHQMRFDLSEGFPMVTTKKLHMKSIIHELL 60 Query: 61 WFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLK 120 WFL GDTN+ YL EN V IW+EWADENGDLGPVYG QWR++ DG+ +DQI V++++K Sbjct: 61 WFLSGDTNVRYLQENGVRIWNEWADENGDLGPVYGSQWRSFTGRDGKTVDQIQWVIDEIK 120 Query: 121 NDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIAS 180 +PDSRR+IVSAWN ELDKMAL PCH FQFYVA+GKLSCQLYQRS D FLG+PFNIAS Sbjct: 121 RNPDSRRLIVSAWNPAELDKMALPPCHLLFQFYVANGKLSCQLYQRSGDTFLGVPFNIAS 180 Query: 181 YALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIF 240 YALL HM+A LEVGDFV T GD HLY NH++Q LQL+REP+PLPKL++ SIF Sbjct: 181 YALLTHMVAHVTGLEVGDFVHTIGDAHLYLNHIEQVKLQLTREPKPLPKLVLNPDVTSIF 240 Query: 241 DYRFEDFEIEGYDPHPGIKAPVAI 264 D+++ED EI GY+ HP IK VA+ Sbjct: 241 DFKYEDIEIVGYESHPHIKGEVAV 264 >UniRef50_C5BMA3 Thymidylate synthase n=8 Tax=cellular organisms RepID=TYSY_TERTT Length = 277 Score = 355 bits (910), Expect = 1e-96, Method: Compositional matrix adjust. Identities = 165/277 (59%), Positives = 204/277 (73%), Gaps = 13/277 (4%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL 60 MKQYLELM+ V D G +K DRTGTGT+S+FG+QMRF+L GFPLVTTK+CHL+SIIHELL Sbjct: 1 MKQYLELMRHVRDNGVRKEDRTGTGTVSVFGYQMRFDLSQGFPLVTTKKCHLKSIIHELL 60 Query: 61 WFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLK 120 WFL G+TNIAYL+ N V IWD WA E+GDLGP+YG QWR+WP +G +DQI+ ++ Q+K Sbjct: 61 WFLNGETNIAYLNNNGVKIWDAWATESGDLGPIYGAQWRSWPAQNGETLDQISQLIEQIK 120 Query: 121 NDPDSRRIIVSAWNVGEL-------------DKMALAPCHAFFQFYVADGKLSCQLYQRS 167 + PDSRR+I+SAWN L KMAL PCH FQFYV +G+LSCQLYQRS Sbjct: 121 HKPDSRRLIISAWNPALLPDESISPQDNVRNGKMALPPCHTLFQFYVLEGRLSCQLYQRS 180 Query: 168 CDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPL 227 D+FLG+PFNIASYALL M+AQ L GDFV T GD HLY NH++Q QL R+P PL Sbjct: 181 ADIFLGVPFNIASYALLTMMIAQVTGLAPGDFVHTFGDAHLYLNHLEQVDTQLQRQPLPL 240 Query: 228 PKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 P + I + IF + F+DFE++ Y HP I AP+++ Sbjct: 241 PTMAINPAVKDIFGFCFDDFELQNYQAHPHIAAPISV 277 >UniRef50_Q1Q8B2 Thymidylate synthase n=702 Tax=root RepID=TYSY_PSYCK Length = 290 Score = 342 bits (877), Expect = 8e-93, Method: Compositional matrix adjust. Identities = 160/279 (57%), Positives = 205/279 (73%), Gaps = 16/279 (5%) Query: 2 KQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLW 61 + YL+L++ VL+EGT+K DRTGTGTLS FG Q+RFNL DGFPL+TTK+ HL+SI +ELLW Sbjct: 12 QAYLDLLRLVLNEGTEKGDRTGTGTLSHFGAQLRFNLADGFPLLTTKKVHLKSITYELLW 71 Query: 62 FLQGDTNIAYLHENNVTIWDEWADEN---------GDLGPVYGKQWR---AWPTPDGRH- 108 FL G T++ YL +N V IW+EWA GDLGP+YG QWR A T DG++ Sbjct: 72 FLNGSTHVDYLQQNGVRIWNEWATSEQTARFNRPAGDLGPIYGHQWRNYGATTTADGQYN 131 Query: 109 ---IDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQ 165 +DQI V+ Q+K +P+SRR+IVS WN GE D++AL PCH FQF+VAD KLSCQLYQ Sbjct: 132 SDGVDQIAQVVEQIKTNPNSRRLIVSGWNPGEADQVALPPCHTLFQFFVADNKLSCQLYQ 191 Query: 166 RSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPR 225 RS D+FLG+PFNIASYA+L HM+AQ C+LEVG+F+WTGGD H+Y NH +Q LQL+R Sbjct: 192 RSADLFLGVPFNIASYAMLTHMVAQVCNLEVGEFIWTGGDCHIYQNHREQVELQLTRSLY 251 Query: 226 PLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 LP L + + IF + +ED ++GY+ HP IKA VA+ Sbjct: 252 TLPTLALNPNVKDIFAFNYEDISVDGYESHPAIKAQVAV 290 >UniRef50_Q4A611 Thymidylate synthase n=15 Tax=Mollicutes RepID=TYSY_MYCS5 Length = 289 Score = 320 bits (819), Expect = 5e-86, Method: Compositional matrix adjust. Identities = 158/294 (53%), Positives = 203/294 (69%), Gaps = 35/294 (11%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL 60 MKQYL L++ + GT K DRT GT+S+FG Q R+NL++GFPL+TTK+ ++I HELL Sbjct: 1 MKQYLHLLEHIKTSGTFKKDRTNIGTISLFGLQARYNLKEGFPLLTTKKMAWKAICHELL 60 Query: 61 WFLQGDTNIAYLHENNVTIWDEW-----------------------------ADENGDLG 91 WFL+GDTNI YL +NNV IW+EW A + G+LG Sbjct: 61 WFLKGDTNIKYLVDNNVNIWNEWPYEIFKKSNDYQGESLKEFSQKIKEDSSFAQKYGELG 120 Query: 92 PVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQ 151 PVYGKQWR D +DQI+ V+N +KN+P SRR+IVSAWNV ++DKMAL PCHAFFQ Sbjct: 121 PVYGKQWR-----DFFGVDQISQVINDIKNNPTSRRLIVSAWNVAQIDKMALPPCHAFFQ 175 Query: 152 FYVADG-KLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYS 210 FYV D +LS LYQRS D+FLG+PFNIASY+LL+ M+AQ +L+VG+F+ T GD H+YS Sbjct: 176 FYVNDNNELSLHLYQRSGDMFLGVPFNIASYSLLLSMVAQVTNLKVGEFIHTIGDAHIYS 235 Query: 211 NHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 NH+DQ + QL R P LPKLI+ + ++IFD+ FED E+E Y H IKA VA+ Sbjct: 236 NHIDQVNTQLERAPYKLPKLILNKNIKNIFDFTFEDIELENYISHETIKAKVAV 289 >UniRef50_A9NG27 Thymidylate synthase n=12 Tax=cellular organisms RepID=TYSY_ACHLI Length = 288 Score = 315 bits (807), Expect = 1e-84, Method: Compositional matrix adjust. Identities = 154/293 (52%), Positives = 198/293 (67%), Gaps = 34/293 (11%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL 60 MKQYL+L + +++ GT K+DRTGTGT SIFG+QM F+L+DGFPL+TTK+ L+ IIHELL Sbjct: 1 MKQYLDLARHIMENGTLKSDRTGTGTKSIFGYQMFFDLKDGFPLLTTKKTFLKGIIHELL 60 Query: 61 WFLQGDTNIAYLHENNVTIWDEWADEN-----------------------------GDLG 91 WF++GDTNI YL +NNV IW +W +N GDLG Sbjct: 61 WFIKGDTNIKYLVDNNVGIWTDWPYKNYMNSSEYQGESIKEFSDKIRQSDEFAKKWGDLG 120 Query: 92 PVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQ 151 PVYG QWR + +DQI ++N LK +PDSRR+++SAWN E+ +M L PCH Q Sbjct: 121 PVYGSQWRNF-----NGVDQIEYIINTLKTNPDSRRMVLSAWNPAEIGQMMLPPCHTLIQ 175 Query: 152 FYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSN 211 FYV D KLS QLYQRS DVFLG+PFNIASYA+ + M+AQ E+G FV T GD H+Y+N Sbjct: 176 FYVVDNKLSLQLYQRSGDVFLGIPFNIASYAVFLMMVAQVTGFELGSFVHTIGDAHIYTN 235 Query: 212 HMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 H DQ +LQL+R PR LP L I + + D+++EDFE+ GYDP+P IK VA+ Sbjct: 236 HFDQINLQLTRTPRRLPILKINKSITRLEDFKYEDFELVGYDPYPPIKGVVAV 288 >UniRef50_Q98Q31 Thymidylate synthase n=2 Tax=root RepID=TYSY_MYCPU Length = 286 Score = 308 bits (789), Expect = 1e-82, Method: Compositional matrix adjust. Identities = 152/293 (51%), Positives = 195/293 (66%), Gaps = 36/293 (12%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL 60 MKQYL+ ++ VL++G K +RT T+S FG+QMRF+L GFPLVTTK+ + +I HELL Sbjct: 1 MKQYLDFLKWVLEKGKHKENRTSVDTISAFGYQMRFDLSKGFPLVTTKKTNFSAIAHELL 60 Query: 61 WFLQGDTNIAYLHENNVTIWDEW-----------------------------ADENGDLG 91 WF++GDTNI YL +N V IW++W A ++G+LG Sbjct: 61 WFIKGDTNIKYLVDNKVNIWNQWPYESYKKSQDFQSESLKEFIQKIKDDNEFAQKHGNLG 120 Query: 92 PVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQ 151 PVYGKQWR D IDQ+ V+ Q+KN+P+SRR+IVS+WN E+D M L PCH FQ Sbjct: 121 PVYGKQWR-----DFLGIDQLKKVIEQIKNNPNSRRLIVSSWNPSEIDTMLLPPCHTLFQ 175 Query: 152 FYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSN 211 FYV D KLSC LYQRS D FLG+PFNIASYALL ++AQ+ +LEVGDFV + GD H+Y N Sbjct: 176 FYVNDNKLSCHLYQRSADAFLGIPFNIASYALLTFLLAQETNLEVGDFVHSIGDAHIYVN 235 Query: 212 HMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 H++Q QL R P+ LPKLIIK K +IF+ FED E+ Y+ P IK VA+ Sbjct: 236 HLEQVKTQLKRNPKELPKLIIKNK--NIFEINFEDIELVDYEFDPIIKGEVAV 286 >UniRef50_Q27828 Thymidylate synthase n=1 Tax=Paramecium tetraurelia RepID=DRTS_PARTE Length = 462 Score = 290 bits (743), Expect = 3e-77, Method: Compositional matrix adjust. Identities = 141/282 (50%), Positives = 190/282 (67%), Gaps = 21/282 (7%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62 QYL+++ K++ EG K+DRTG GT+SIFG MRFNL FPL+TTK+ R ++ ELLWF Sbjct: 182 QYLDMITKIMKEGVSKDDRTGVGTMSIFGQTMRFNLAQSFPLLTTKKVFFRGVVEELLWF 241 Query: 63 LQGDTNIAYLHENNVTIWD-----EWADENG-------DLGPVYGKQWRAWPTP------ 104 L+G+TN L + V IW+ E+ D G DLGPVYG QWR + Sbjct: 242 LRGNTNGKLLLDKGVKIWEGNGTREYLDTIGLQHRQEHDLGPVYGFQWRHFGAKYKDCQT 301 Query: 105 --DGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQ 162 + +DQ+ ++ LKN+PDSRRII+SAWN +L +MAL PCH QF+VA+GKLSC Sbjct: 302 DYSNQGVDQVKEIIQLLKNNPDSRRIILSAWNPIDLKQMALPPCHVMSQFFVANGKLSCM 361 Query: 163 LYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSR 222 +YQRSCD LG+PFNIASYALL +M+A++C+L +G+FV GDTH+YSNH++ Q+ R Sbjct: 362 MYQRSCDFGLGIPFNIASYALLTYMLAKECNLNLGEFVHVLGDTHIYSNHVEALKKQIER 421 Query: 223 EPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 P P P L IK +S+FDY +EDFE+ GY+ H I+ +A+ Sbjct: 422 VPYPFPLLKIKGN-KSLFDYTYEDFELVGYNAHDKIEMKMAV 462 >UniRef50_B1C3H3 Thymidylate synthase n=6 Tax=Bacteria RepID=B1C3H3_9FIRM Length = 295 Score = 289 bits (739), Expect = 7e-77, Method: Compositional matrix adjust. Identities = 144/298 (48%), Positives = 191/298 (64%), Gaps = 37/298 (12%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL 60 MKQYLE+ + VL+ G ++DRTGTGT S+FG+Q R++L+DGFPL+TTK+ +R I ELL Sbjct: 1 MKQYLEMCKYVLENGEDRSDRTGTGTRSVFGYQTRYDLRDGFPLMTTKKMFIRPIAEELL 60 Query: 61 WFLQGDTNIAYLHENNVTIWDEWADEN--------------------------------G 88 WF++GDTNI YL + NV IW+EW EN G Sbjct: 61 WFIKGDTNIKYLVDRNVKIWNEWPYENYKKSKDYQGETIEEFIEKIKNLPEDDSFVLKYG 120 Query: 89 DLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHA 148 DLGPVYG QWR + + +DQ+ +++ LKNDP SRR I+ AWN ++D M L PCHA Sbjct: 121 DLGPVYGAQWRNF---NYEGVDQLAKLVDSLKNDPFSRRHIICAWNPAQVDNMTLPPCHA 177 Query: 149 FFQFYVADGK--LSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDT 206 F QFYV+ K LSCQLYQRS D+FLG+PFNIASYAL+V M+A+ C E +FV T GD Sbjct: 178 FLQFYVSADKKYLSCQLYQRSADIFLGVPFNIASYALMVEMLARTCGYEAKEFVHTIGDA 237 Query: 207 HLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 H+Y +H D QL R+P P KL++ + +SIFDY+ ED +IE Y + + V++ Sbjct: 238 HIYKDHFDVVKQQLERKPLPKCKLVLNPEVKSIFDYKIEDIKIEDYQSYGKLVGKVSV 295 >UniRef50_P04818 Thymidylate synthase n=326 Tax=root RepID=TYSY_HUMAN Length = 313 Score = 285 bits (729), Expect = 1e-75, Method: Compositional matrix adjust. Identities = 144/282 (51%), Positives = 186/282 (65%), Gaps = 20/282 (7%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62 QYL +Q +L G +K+DRTGTGTLS+FG Q R++L+D FPL+TTKR + ++ ELLWF Sbjct: 32 QYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWF 91 Query: 63 LQGDTNIAYLHENNVTIWDEWAD------------ENGDLGPVYGKQWRAWPTP------ 104 ++G TN L V IWD E GDLGPVYG QWR + Sbjct: 92 IKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEGDLGPVYGFQWRHFGAEYRDMES 151 Query: 105 --DGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQ 162 G+ +DQ+ V++ +K +PD RRII+ AWN +L MAL PCHA QFYV + +LSCQ Sbjct: 152 DYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSCQ 211 Query: 163 LYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSR 222 LYQRS D+ LG+PFNIASYALL +M+A L+ GDF+ T GD H+Y NH++ +QL R Sbjct: 212 LYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQR 271 Query: 223 EPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 EPRP PKL I RK E I D++ EDF+IEGY+PHP IK +A+ Sbjct: 272 EPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPHPTIKMEMAV 313 >UniRef50_Q2G6V6 Thymidylate synthase n=14 Tax=Bacteria RepID=TYSY_NOVAD Length = 314 Score = 282 bits (721), Expect = 9e-75, Method: Compositional matrix adjust. Identities = 145/301 (48%), Positives = 189/301 (62%), Gaps = 39/301 (12%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDG-FPLVTTKRCHLRSIIHELLW 61 QYL+LM+++ + G ++ DRTG GT S+FG ++RF+L DG PL+TTKR + ++ E LW Sbjct: 14 QYLDLMRRIWEHGDERVDRTGVGTRSVFGAELRFDLSDGRMPLLTTKRVYWKTATREFLW 73 Query: 62 FLQGDTNIAYLHENNVTIWDEW-----------------------ADEN-----GDLGPV 93 FL G+TNI L V IW +W ADE GDLGPV Sbjct: 74 FLTGNTNIRPLCAQGVEIWTDWPLDRYRKETGDDISRKDFSARIVADEAFALRWGDLGPV 133 Query: 94 YGKQWRAWPT--PDG--------RHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMAL 143 YGKQW WP P G ++Q+ V++ L+++P SRR I+ WNV E+D+MAL Sbjct: 134 YGKQWVDWPVFEPVGDGLFRRREAGVNQVADVVDSLRHNPGSRRHIIEGWNVAEIDRMAL 193 Query: 144 APCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTG 203 PCH +QF+V+ +L+ LYQRSCDV LGLPFN+ ALLV ++AQQCDL+ G+ VW G Sbjct: 194 PPCHKTYQFHVSGNRLNGLLYQRSCDVALGLPFNLWGAALLVRLLAQQCDLQPGELVWMG 253 Query: 204 GDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263 GDTHLY NH D QLSREP P+L I R+P+SIF YR EDFE+ GY P + APVA Sbjct: 254 GDTHLYLNHADLVEAQLSREPEGDPRLAILRRPDSIFGYRIEDFEVTGYAPQGHLSAPVA 313 Query: 264 I 264 + Sbjct: 314 V 314 >UniRef50_Q0FG99 Thymidylate synthase n=4 Tax=root RepID=Q0FG99_9RHOB Length = 292 Score = 282 bits (721), Expect = 1e-74, Method: Compositional matrix adjust. Identities = 145/292 (49%), Positives = 188/292 (64%), Gaps = 28/292 (9%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL 60 MKQYL+ + ++D G + +DRTG GTLS+FG+Q+RFNLQ+GFP VTTK+ RSI+ ELL Sbjct: 1 MKQYLDALNYIMDNGEEVSDRTGVGTLSVFGYQIRFNLQEGFPAVTTKKLAWRSIVGELL 60 Query: 61 WFLQGDTNIAYLHE-----------NNVTIWDEWADENG------------DLGPVYGKQ 97 WFL+G T+ L E + TIW AD G +LGPVYG Q Sbjct: 61 WFLEGSTDERRLAELTFNKDRTDLVHKKTIWTANADAQGAELGYENNDLIKELGPVYGHQ 120 Query: 98 WRAWPTPD---GRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYV 154 WR + D DQI ++N++KN+PDSRR+I+SAWN ++++MAL PCH QF V Sbjct: 121 WRHFDGTDKDISLSTDQIIWLINEIKNNPDSRRMILSAWNPNQINEMALPPCHTMAQFRV 180 Query: 155 ADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMD 214 +GKLSCQLYQRS D+FLG+PFNIASY+LL HM+AQ CDL+VG FVW GGD H+Y NH Sbjct: 181 MNGKLSCQLYQRSADMFLGVPFNIASYSLLTHMLAQLCDLKVGSFVWVGGDCHIYKNHKK 240 Query: 215 QTHLQLSREPRPLPKLIIK--RKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 Q QL R P+ LP L + + + R + ++ YDP IKAP+AI Sbjct: 241 QVLEQLKRTPKSLPNLEMPSFSNLDELLQTRPIGYVLKNYDPMDSIKAPMAI 292 >UniRef50_Q3J0W9 Thymidylate synthase n=12 Tax=Bacteria RepID=TYSY_RHOS4 Length = 298 Score = 280 bits (717), Expect = 2e-74, Method: Compositional matrix adjust. Identities = 138/293 (47%), Positives = 182/293 (62%), Gaps = 30/293 (10%) Query: 2 KQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDG-FPLVTTKRCHLRSIIHELL 60 +QYL+L+ + L+ G ++ DRTG GTLS+FG +RF+L G P++TTKR + ++ + E+L Sbjct: 6 QQYLDLLAQTLERGDRRVDRTGVGTLSLFGAMLRFDLSGGQVPILTTKRVYWKTAVKEML 65 Query: 61 WFLQGDTNIAYLHENNVTIWDEW----------------------------ADENGDLGP 92 WFL G TNI L + NV IW +W A G+LGP Sbjct: 66 WFLTGGTNIRPLLQENVRIWSDWPLAAYRRESGEEISQAAFEQRVLEDEAFAARWGELGP 125 Query: 93 VYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQF 152 VYGKQWR W PDG DQI ++ L+ +P SRR++ AWNV E+ +MAL PCH +Q+ Sbjct: 126 VYGKQWRRWLGPDGHEHDQIAALIETLRTNPSSRRMLFHAWNVAEVGQMALPPCHMVYQY 185 Query: 153 YV-ADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSN 211 +V +DG+L+ LYQRS D+ LG PFN A L M+AQQ L GD VW GGDTHLY N Sbjct: 186 HVTSDGRLNALLYQRSVDLLLGAPFNFVGAAALQLMIAQQAGLVPGDLVWVGGDTHLYLN 245 Query: 212 HMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 H+DQ Q R PR P++ + R+ +SI DYR EDF +EGYDPHP I A VA+ Sbjct: 246 HLDQAREQTGRAPRDWPRMRLLRRADSIDDYRIEDFAVEGYDPHPAIAAEVAV 298 >UniRef50_Q4A320 Bifunctional dihydrofolate reductase-thymidylate synthase n=2 Tax=dsDNA viruses, no RNA stage RepID=Q4A320_EHV86 Length = 480 Score = 270 bits (689), Expect = 5e-71, Method: Compositional matrix adjust. Identities = 135/276 (48%), Positives = 177/276 (64%), Gaps = 20/276 (7%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62 QYL+L+ KVL+ G ++DRTGTGT+S+FG MRFNL FPL+TTKR + + I+ ELLWF Sbjct: 199 QYLQLISKVLEHGEYRSDRTGTGTVSLFGETMRFNLSTHFPLLTTKRTYWKGIVEELLWF 258 Query: 63 LQGDTNIAYLHENNVTIWDEWA------------DENGDLGPVYGKQWRAW--------P 102 ++G TN L NV IWD +E GDLGPVYG QWR + Sbjct: 259 IRGSTNANELAAKNVKIWDGNGSRDFLDSVGLVDNEEGDLGPVYGFQWRHFGADYKTMHD 318 Query: 103 TPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQ 162 + D + DQ+ V++Q+KN+P SRRII+SAWN L+KMAL PCH QFYV DG LSCQ Sbjct: 319 SYDSQGTDQLQNVIDQIKNNPTSRRIIMSAWNPNALEKMALPPCHLMCQFYVHDGMLSCQ 378 Query: 163 LYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSR 222 +YQRS D+ LG+PFNIASYALL ++A +L+ G+F+ GD H+Y+NH+D QL R Sbjct: 379 MYQRSADIGLGVPFNIASYALLTCLIAHFTNLKPGEFIHVIGDAHVYTNHIDALKTQLKR 438 Query: 223 EPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGI 258 +P P + I P++IFD +D + Y HP I Sbjct: 439 KPYDFPTIHINNMPKTIFDVTSDDIILNDYKCHPKI 474 >UniRef50_Q4U9G5 Bifunctional dihydrofolate reductase/thymidilate synthase, putative n=7 Tax=root RepID=Q4U9G5_THEAN Length = 523 Score = 267 bits (683), Expect = 2e-70, Method: Compositional matrix adjust. Identities = 130/281 (46%), Positives = 181/281 (64%), Gaps = 20/281 (7%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62 QYLE++ +L+ G K +RTG ++ FG+QMRF+L FPL+TTK+ LR II EL+WF Sbjct: 242 QYLEILADILNNGYHKKNRTGVDCIAKFGYQMRFDLSQSFPLLTTKKVFLRGIIEELIWF 301 Query: 63 LQGDTNIAYLHENNVTIWDE------------WADENGDLGPVYGKQWRAWPTP------ 104 ++G TN L + NV IW+ + E DLGPVYG QWR + Sbjct: 302 IRGSTNGNELLKKNVRIWELNGARSFLDNLGFYDREEQDLGPVYGFQWRHFGAKYIDMHA 361 Query: 105 --DGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQ 162 + IDQ++ V+ ++KN+PD+RR+IV +WNV +L KMAL PCH FQF+VADG LSC Sbjct: 362 DYTDQGIDQLSLVIERIKNNPDNRRLIVCSWNVADLSKMALPPCHLLFQFFVADGTLSCM 421 Query: 163 LYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSR 222 ++QRSCD+ LG+PFNIASY+LL +M+A C L+ G+FV GD H+Y+NH+D Q+SR Sbjct: 422 MHQRSCDMGLGVPFNIASYSLLTYMIAHICGLKPGEFVHNLGDAHIYNNHIDAIKEQISR 481 Query: 223 EPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263 P P P L + ++ I D+ +D ++E Y HP IK +A Sbjct: 482 VPYPFPTLKLNKEITRIEDFTIDDIKVENYRCHPLIKMEMA 522 >UniRef50_Q2TA32 Thymidylate synthase n=5 Tax=cellular organisms RepID=TYSY_BOVIN Length = 354 Score = 265 bits (676), Expect = 2e-69, Method: Compositional matrix adjust. Identities = 143/320 (44%), Positives = 188/320 (58%), Gaps = 58/320 (18%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62 QYL ++ +L G +++DRTGTGTLS+FG Q R+NL+D FPL+TTKR + ++ ELLWF Sbjct: 35 QYLGQIEHILRCGFRRDDRTGTGTLSVFGMQARYNLRDEFPLLTTKRVFWKGVLEELLWF 94 Query: 63 LQGDTNIAYLHENNVTIWDEWADEN------------GDLGPVYGKQWRAWPTP------ 104 ++G TN L V IWD + GDLGPVYG QWR + Sbjct: 95 IKGSTNAKELSSKGVKIWDANGSRDFLDGLGFSDRAEGDLGPVYGFQWRHFGAEYKDMDS 154 Query: 105 --DGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQ 162 G+ +DQ+ V++ +K +P+ RRII+ AWN +L MAL PCHA QFYV +G+LSCQ Sbjct: 155 EYSGQGVDQLQKVIDTIKTNPNDRRIILCAWNPKDLPLMALPPCHALCQFYVVNGELSCQ 214 Query: 163 LYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQ--- 219 LYQRS D+ LG+PFNIASYALL +M+A DL+ GDFV T GD H+Y NH++ Q Sbjct: 215 LYQRSGDMGLGVPFNIASYALLTYMIAHITDLKPGDFVHTLGDAHIYLNHIEPLKTQALM 274 Query: 220 -----------------------------------LSREPRPLPKLIIKRKPESIFDYRF 244 L REPRP PKL I RK E+I D++ Sbjct: 275 ELRGQSSRSLDGDGQAGTSRWAPVATDTERDRCCELQREPRPFPKLKILRKVETIDDFQA 334 Query: 245 EDFEIEGYDPHPGIKAPVAI 264 EDF+IEGY+P+P IK +A+ Sbjct: 335 EDFQIEGYNPNPTIKMEMAV 354 >UniRef50_D2CLW7 Dihydrofolate reductase-thymidylate synthase n=75 Tax=Plasmodium RepID=D2CLW7_9APIC Length = 641 Score = 263 bits (673), Expect = 3e-69, Method: Compositional matrix adjust. Identities = 129/281 (45%), Positives = 182/281 (64%), Gaps = 20/281 (7%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62 QYL ++ V+ G +++DRTG G LS FG+ M++NL + FPL+TTK+ +R II ELLWF Sbjct: 360 QYLNIIYDVMMNGNKQDDRTGVGVLSKFGYMMKYNLAEYFPLLTTKKLFVRGIIEELLWF 419 Query: 63 LQGDTNIAYLHENNVTIWD-----EWAD-------ENGDLGPVYGKQWR--------AWP 102 ++G+TN L NV IW+ E+ D E DLGP+YG QWR + Sbjct: 420 IRGETNGNILLNKNVRIWEANGTREFLDNRKLFDREVNDLGPIYGFQWRHFGAEYTNMYD 479 Query: 103 TPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQ 162 + + IDQ+ ++N +KN+P SRRII+ AWNV +LDKMAL PCH QFY+ DGKLSC Sbjct: 480 NYENKGIDQLKNIINLIKNEPTSRRIILCAWNVKDLDKMALPPCHILCQFYIFDGKLSCI 539 Query: 163 LYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSR 222 +YQRSCD+ LG+PFNIASY++ +M+AQ C+L+ +F+ G+ H+Y+NH+D +QL+R Sbjct: 540 MYQRSCDLGLGVPFNIASYSIFTYMLAQVCNLQPAEFIHVLGNAHIYNNHIDSLKIQLNR 599 Query: 223 EPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263 P P P L + + ++I D+ DF IE Y H I +A Sbjct: 600 IPYPFPTLKLNPEIKNIEDFTISDFTIENYVHHDKIAMDMA 640 >UniRef50_Q27713 Thymidylate synthase n=5 Tax=Plasmodium RepID=DRTS_PLABA Length = 587 Score = 261 bits (667), Expect = 2e-68, Method: Compositional matrix adjust. Identities = 126/281 (44%), Positives = 179/281 (63%), Gaps = 20/281 (7%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62 QYL ++ ++ G +++DRTG G LS FG+ M+FNL + FPL+TTK+ +R II ELLWF Sbjct: 306 QYLNIIYDIIMHGNKQDDRTGVGVLSKFGYMMKFNLNEYFPLLTTKKLFIRGIIEELLWF 365 Query: 63 LQGDTNIAYLHENNVTIWD-----EWAD-------ENGDLGPVYGKQWRAWPTP------ 104 ++G+TN L E NV IW+ E+ D E DLGP+YG QWR + Sbjct: 366 IRGETNGNTLLEKNVRIWEANGTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYTDMHD 425 Query: 105 --DGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQ 162 + +DQ+ ++N +KNDP RRII+ AWNV LD+MAL PCH QFYV DGKLSC Sbjct: 426 NYKDKGVDQLKNIINLIKNDPTCRRIILCAWNVKNLDQMALPPCHILCQFYVFDGKLSCI 485 Query: 163 LYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSR 222 +YQRSCD+ LG+PFNIASY++ +M+AQ C+L+ +F+ G+ H+Y+NH++ +QL+R Sbjct: 486 MYQRSCDLGLGVPFNIASYSIFTYMIAQVCNLQAAEFIHVLGNAHVYNNHIESLKIQLNR 545 Query: 223 EPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263 P P P L + ++I D+ DF ++ Y H I +A Sbjct: 546 TPYPFPTLKLNPDIKNIEDFTISDFTVQNYVHHDKINMDMA 586 >UniRef50_Q27783 Thymidylate synthase n=25 Tax=Trypanosomatidae RepID=DRTS_TRYBB Length = 527 Score = 261 bits (667), Expect = 2e-68, Method: Compositional matrix adjust. Identities = 131/284 (46%), Positives = 178/284 (62%), Gaps = 21/284 (7%) Query: 2 KQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDG-FPLVTTKRCHLRSIIHELL 60 +QYL L+ +++DEG K DRTG GT S+FG QMRF+L++ PL+TTKR R + ELL Sbjct: 244 EQYLNLVGRIIDEGCTKCDRTGVGTRSLFGAQMRFSLRNNRLPLLTTKRVFWRGVCEELL 303 Query: 61 WFLQGDTNIAYLHENNVTIWD-----EWADENG-------DLGPVYGKQWRAWPT----- 103 WFL+G+TN L + + IWD + D G DLGPVYG QWR + Sbjct: 304 WFLRGETNAKLLSDKGIHIWDGNGSRAFLDSRGLTDYDEMDLGPVYGFQWRHFGADYISC 363 Query: 104 ---PDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLS 160 +G+ +DQI ++ L +PD RR+I +AWN L +MAL PCH QFYV++G+LS Sbjct: 364 KVDSEGKGVDQIANIVKSLIENPDDRRMICTAWNPAALPRMALPPCHMMAQFYVSNGELS 423 Query: 161 CQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQL 220 C LYQRSCD+ LG+PFNIASYALL +MA+ L G+ V T GD H+YSNH++ QL Sbjct: 424 CMLYQRSCDMGLGVPFNIASYALLTFLMAKASGLRPGELVHTLGDAHVYSNHVEPCRKQL 483 Query: 221 SREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 R PRP P ++ K+ E + D++ D E+ Y P+P I +A+ Sbjct: 484 KRVPRPFPFIVFKQDKEFLEDFQESDIEVIDYSPYPVISMEMAV 527 >UniRef50_O02604 Thymidylate synthase n=87 Tax=Plasmodium RepID=DRTS_PLAVI Length = 623 Score = 258 bits (660), Expect = 1e-67, Method: Compositional matrix adjust. Identities = 129/281 (45%), Positives = 180/281 (64%), Gaps = 20/281 (7%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62 QYL ++ ++ G ++ DRTG G +S FG+ M+FNL + FPL+TTK+ LR II ELLWF Sbjct: 342 QYLGIIYDIIMNGNKQGDRTGVGVMSNFGYMMKFNLSEYFPLLTTKKLFLRGIIEELLWF 401 Query: 63 LQGDTNIAYLHENNVTIWD-----EWAD-------ENGDLGPVYGKQWRAWPTP------ 104 ++G+TN L NV IW+ E+ D E DLGP+YG QWR + Sbjct: 402 IRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYTNMHD 461 Query: 105 --DGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQ 162 + + +DQ+ V++ +KN+P SRRII+ AWNV +LD+MAL PCH QFYV DGKLSC Sbjct: 462 NYEDKGVDQLKNVIHLIKNEPTSRRIILCAWNVKDLDQMALPPCHILCQFYVFDGKLSCI 521 Query: 163 LYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSR 222 +YQRSCD+ LG+PFNIASY++ HM+AQ C+L+ F+ G+ H+Y+NH+D +QL+R Sbjct: 522 MYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQPAQFIHILGNAHVYNNHVDSLKVQLNR 581 Query: 223 EPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263 P P P L + + ++I D+ DF IE Y H I +A Sbjct: 582 IPYPFPTLKLNPEVKNIEDFTISDFTIENYVHHDKITMEMA 622 >UniRef50_C3RUB2 Dihydrofolate reductase-thymidylate synthase n=16 Tax=Plasmodium vivax RepID=C3RUB2_PLAVI Length = 630 Score = 258 bits (658), Expect = 2e-67, Method: Compositional matrix adjust. Identities = 129/281 (45%), Positives = 180/281 (64%), Gaps = 20/281 (7%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62 QYL ++ ++ G ++ DRTG G +S FG+ M+FNL + FPL+TTK+ LR II ELLWF Sbjct: 349 QYLGIIYDIIMNGNKQGDRTGVGVMSKFGYMMKFNLSEYFPLLTTKKLFLRGIIEELLWF 408 Query: 63 LQGDTNIAYLHENNVTIWD-----EWAD-------ENGDLGPVYGKQWRAWPTP------ 104 ++G+TN L NV IW+ E+ D E DLGP+YG QWR + Sbjct: 409 IRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYTNMHD 468 Query: 105 --DGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQ 162 + + +DQ+ V++ +KN+P SRRII+ AWNV +LD+MAL PCH QFYV DGKLSC Sbjct: 469 NYEDKGVDQLKNVIHLIKNEPTSRRIILCAWNVKDLDQMALPPCHILCQFYVFDGKLSCI 528 Query: 163 LYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSR 222 +YQRSCD+ LG+PFNIASY++ HM+AQ C+L+ F+ G+ H+Y+NH+D +QL+R Sbjct: 529 MYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQPAQFIHILGNAHVYNNHVDSLKVQLNR 588 Query: 223 EPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263 P P P L + + ++I D+ DF IE Y H I +A Sbjct: 589 IPYPFPTLKLNPEVKNIEDFTISDFTIENYVHHDKITMEMA 629 >UniRef50_C4Q3X9 Thymidylate synthase n=3 Tax=root RepID=C4Q3X9_SCHMA Length = 577 Score = 255 bits (651), Expect = 1e-66, Method: Compositional matrix adjust. Identities = 134/282 (47%), Positives = 179/282 (63%), Gaps = 21/282 (7%) Query: 4 YLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQD-GFPLVTTKRCHLRSIIHELLWF 62 YL L++ +L G ++ DRT TGT +FG Q+RF+L++ +PL+TTK R I+ ELLWF Sbjct: 296 YLNLLRYILANGVERRDRTDTGTFGVFGPQLRFSLRNHEYPLLTTKTVFFRGIVEELLWF 355 Query: 63 LQGDTNIAYLHENNVTIWD-----EWAD-------ENGDLGPVYGKQWRAWPTP------ 104 ++G TN L E NV WD E+ D E GDLGPVYG QWR Sbjct: 356 IRGSTNSRELAEKNVHFWDANGSREFLDGLGFTEREEGDLGPVYGFQWRHSGAEYVDCQT 415 Query: 105 --DGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQ 162 G+ +DQ+ V+ ++ P RRI++ AWNV +L KMAL PCH QFYVA+ +LSCQ Sbjct: 416 DYTGQGVDQLADVIKLIRERPWDRRIMIVAWNVKDLRKMALPPCHCLVQFYVANDELSCQ 475 Query: 163 LYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSR 222 LYQRS D+ LG+PFNIASYALL M+A L+ G+FV T GD H+YSNH + Q+ R Sbjct: 476 LYQRSGDMGLGVPFNIASYALLTCMIAHVTGLKPGEFVHTIGDAHIYSNHREALLEQVKR 535 Query: 223 EPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 PRP PKL I R+ ++I D++FEDF++ Y P+P I +A+ Sbjct: 536 VPRPFPKLEIIREVKNIDDFKFEDFKLIDYKPYPKIPMKMAL 577 >UniRef50_A5KSZ1 Thymidylate synthase n=1 Tax=candidate division TM7 genomosp. GTL1 RepID=A5KSZ1_9BACT Length = 280 Score = 254 bits (649), Expect = 2e-66, Method: Compositional matrix adjust. Identities = 128/273 (46%), Positives = 172/273 (63%), Gaps = 11/273 (4%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62 QYL+LM +L +G K R G +IFG+Q+RF+++ GFPL+TTK+ + ++HEL WF Sbjct: 7 QYLQLMADILKDGRSKPSRGIHGLKAIFGYQIRFDMRQGFPLLTTKKMPFKILLHELFWF 66 Query: 63 LQGDTNIAYLHENNVTIWDEWADENGD-LGPVYGKQWRAWPTPDGRHIDQITTVLNQLKN 121 + G +++ YLHE+ + WD + E D LG VYG QWR W PDG DQ+ + Q+K Sbjct: 67 ISGSSSVDYLHEHKIHYWDGFLHEGSDDLGRVYGVQWRHWLRPDGSQFDQLQWAIEQIKT 126 Query: 122 DPDSRRIIVSAWNVGEL-DK---------MALAPCHAFFQFYVADGKLSCQLYQRSCDVF 171 +P+S+ IIVSAWN GEL DK M L PCH FQF V GKL QLYQRS DVF Sbjct: 127 NPNSKAIIVSAWNAGELGDKRWNPNDYGDMRLPPCHTMFQFDVTGGKLRMQLYQRSSDVF 186 Query: 172 LGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLI 231 LGLPFNIA YA+L+HM+A DLE + + + G HLY N ++ Q+ R+P PKL Sbjct: 187 LGLPFNIAQYAMLLHMVAYLADLEPRELIISIGSAHLYRNQIEPAKEQVRRKPYRFPKLT 246 Query: 232 IKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 I + I D++ ++F +EGY HP IK + I Sbjct: 247 IAGDVKDIDDFKEKNFSLEGYQSHPHIKTDLVI 279 >UniRef50_Q67JQ1 Thymidylate synthase n=1 Tax=Symbiobacterium thermophilum RepID=TYSY_SYMTH Length = 283 Score = 254 bits (648), Expect = 3e-66, Method: Compositional matrix adjust. Identities = 126/277 (45%), Positives = 178/277 (64%), Gaps = 16/277 (5%) Query: 3 QYLELMQKVLDEGTQK-------NDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSI 55 QYLEL +++L E Q+ +RTG GT+ +FG ++ + ++GFP +TTK+ S+ Sbjct: 6 QYLELCREILAENEQEIAEGRWTPNRTGMGTVGVFGRMLKHDFKEGFPALTTKKLFFNSV 65 Query: 56 IHELLWFLQGDTNIAYLHENNVTIWDEWADEN-GDLGPVYGKQWRAWPTPDGRHIDQITT 114 ELLWFL G T++ +LHE IWD+ A N G LGP+YGKQWRAW DGR DQI Sbjct: 66 KAELLWFLAGRTDLEFLHERGCHIWDKDAARNGGKLGPIYGKQWRAWEGADGRTYDQIAW 125 Query: 115 VLNQLKN--------DPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQR 166 V+ Q++ P+SRR++VS WNV +L++MAL PCH FQF+V DG+L ++QR Sbjct: 126 VIQQIREIAADPERPHPNSRRLVVSPWNVADLEEMALPPCHGPFQFHVKDGRLHLAVWQR 185 Query: 167 SCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRP 226 S D+FLG+PFNIASY+LL+HM+AQ L VG + D H+Y N +DQ LQL+REP P Sbjct: 186 SADLFLGVPFNIASYSLLLHMVAQVTGLAVGTYTHYLNDVHIYRNLLDQVRLQLTREPYP 245 Query: 227 LPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263 LP+L + + I + +D ++ Y HP I+ ++ Sbjct: 246 LPRLWLNPEVREIDQFTMDDIQLVDYKHHPPIRGELS 282 >UniRef50_Q04FR4 Thymidylate synthase n=279 Tax=cellular organisms RepID=TYSY_OENOB Length = 319 Score = 253 bits (647), Expect = 3e-66, Method: Compositional matrix adjust. Identities = 134/314 (42%), Positives = 181/314 (57%), Gaps = 51/314 (16%) Query: 2 KQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLW 61 +QYL L +++L+ G K DRT TGT SIFG QMRF+L +GFPL+T+K+ I ELLW Sbjct: 6 EQYLNLARRILETGASKMDRTKTGTHSIFGAQMRFDLSEGFPLLTSKKVAFGRIKSELLW 65 Query: 62 FLQGDTNIAYLHENNVTIWDEW-------------------------------------- 83 FL+GD NI +L +++ IWDEW Sbjct: 66 FLRGDNNIRFLLQHHNHIWDEWPFKKWVESNEYKGPDMTDFGLRTQKDPIFAEQYKEQKK 125 Query: 84 ------------ADENGDLGPVYGKQWRAWP-TPDGRHIDQITTVLNQLKNDPDSRRIIV 130 + + G +G VYGK WR WP D +DQIT ++N++K +P+SRR+I+ Sbjct: 126 IFVDRILNDDEFSKKFGTIGDVYGKLWRHWPDANDDGSVDQITRLINEIKVNPNSRRLIL 185 Query: 131 SAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQ 190 +AW+ L CH QFYV DGK+S Q+YQRS D FLG+PFNIASY+LL+ M+A Sbjct: 186 TAWDPETTPFATLPSCHVMSQFYVVDGKISLQMYQRSADYFLGVPFNIASYSLLLSMVAA 245 Query: 191 QCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIE 250 Q LEVG+F+ T GD H+Y+NH+DQ QLS+ LP L + +SIFDY D ++E Sbjct: 246 QTGLEVGEFIHTIGDAHIYNNHVDQIKEQLSKPTHKLPTLKLNPDVKSIFDYEMSDIKLE 305 Query: 251 GYDPHPGIKAPVAI 264 Y IKAP+A+ Sbjct: 306 NYIHEDVIKAPIAV 319 >UniRef50_B6AE97 Thymidylate synthase family protein n=4 Tax=cellular organisms RepID=B6AE97_9CRYT Length = 549 Score = 253 bits (645), Expect = 5e-66, Method: Compositional matrix adjust. Identities = 129/283 (45%), Positives = 176/283 (62%), Gaps = 21/283 (7%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62 QYL+++ VL G + +RTG T SIFG MRF+L++ FPL+TTK LR I EL+WF Sbjct: 267 QYLDMLSNVLQNGHYRENRTGINTYSIFGASMRFDLRESFPLLTTKNVALRIIFEELMWF 326 Query: 63 LQGDTNIAYLHENNVTIW-----DEWAD-------ENGDLGPVYGKQWRAWPTP------ 104 ++GDTN +L + V IW E+ + E DLGP+YG QWR + Sbjct: 327 IKGDTNGNHLLDKKVFIWAGNGSKEYLNKVGLGYREENDLGPIYGFQWRHFNAEYKTMHD 386 Query: 105 --DGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYV-ADGKLSC 161 +G+ +DQ+ ++ LK +P RR I+SAWN + MAL PCH QFYV + +LSC Sbjct: 387 NYNGQGVDQLANLIESLKKNPYDRRHILSAWNPSAVKYMALPPCHILSQFYVDNNNRLSC 446 Query: 162 QLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLS 221 LYQRSCD+ LG PFNIASY+LL M+A C E G+F+ GD H+Y NH++Q Q+ Sbjct: 447 SLYQRSCDLGLGCPFNIASYSLLCVMIAHICGYEPGEFIHFIGDVHIYENHVEQLKQQIK 506 Query: 222 REPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 R PRP P+L +KRK + + D+ +ED EI GY PHP I+ +A+ Sbjct: 507 RLPRPFPQLRLKRKVDKVEDFIWEDIEIIGYYPHPTIRMEMAV 549 >UniRef50_O96650 Thymidylate synthase n=17 Tax=root RepID=TYSY_ASCSU Length = 294 Score = 252 bits (644), Expect = 8e-66, Method: Compositional matrix adjust. Identities = 128/284 (45%), Positives = 181/284 (63%), Gaps = 21/284 (7%) Query: 2 KQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDG-FPLVTTKRCHLRSIIHELL 60 ++YL ++ ++DEG + DRTG GTLS+FG ++L++G PL+TTKR + + ++ ELL Sbjct: 11 RKYLRQIKHIIDEGDKVIDRTGVGTLSLFGLHSTYSLRNGVIPLLTTKRVYWKGVVEELL 70 Query: 61 WFLQGDTNIAYLHENNVTIWD-----EWADENG-------DLGPVYGKQWRAWPTP---- 104 WF++GDT+ L V IWD E+ D G DLGP+YG QWR + Sbjct: 71 WFIKGDTDAKRLSAKGVKIWDANGSREFLDSQGFKDRPEGDLGPIYGFQWRHFGAEYHGT 130 Query: 105 ----DGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLS 160 G+ +DQ+ V+ Q+KN+P+SRRII++AWNV +L +MAL PCH QF V +G+LS Sbjct: 131 DADYKGQGVDQLADVIEQIKNNPNSRRIILNAWNVKDLHQMALPPCHTLAQFAVKNGELS 190 Query: 161 CQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQL 220 CQLYQRS D+ LG+PFN+ASY LL HM+A C L+ G GD H+Y NH+D QL Sbjct: 191 CQLYQRSGDMGLGVPFNLASYGLLTHMIAHVCALKTGFLHHVLGDAHVYLNHIDALKEQL 250 Query: 221 SREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 SR+PRP P + + + +SI D+ E + GY+P IK P+A+ Sbjct: 251 SRDPRPFPTVHFEGRIDSIDDFTAESIILNGYNPMAPIKMPMAV 294 >UniRef50_Q07422 Thymidylate synthase n=6 Tax=cellular organisms RepID=DRTS_TOXGO Length = 610 Score = 250 bits (638), Expect = 4e-65, Method: Compositional matrix adjust. Identities = 128/285 (44%), Positives = 180/285 (63%), Gaps = 23/285 (8%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62 QYL+L+ +++ G +DRTG G +S FG MR++L FPL+TTKR + ++ ELLWF Sbjct: 326 QYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWF 385 Query: 63 LQGDTNIAYLHENNVTIWD-----EWAD-------ENGDLGPVYGKQWRAWPTP------ 104 ++GDTN +L E V IWD E+ D E GD+GP YG QWR + Sbjct: 386 IRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHT 445 Query: 105 --DGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGK-LSC 161 G+ +DQ+ V+ L+ +P RR++++AWN LD+MAL PCH QFYV D K LSC Sbjct: 446 DYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSC 505 Query: 162 QLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLS 221 +YQRSCDV LG+PFNIASY+LL M+A C+L+ +F+ G+TH+Y+NH++ QL Sbjct: 506 IMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLR 565 Query: 222 REPRPLP--KLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 REPRP P ++ K + + I D+ EDFE+ GY PH I+ +A+ Sbjct: 566 REPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 610 >UniRef50_D2W4C0 Predicted protein n=1 Tax=Naegleria gruberi RepID=D2W4C0_NAEGR Length = 535 Score = 249 bits (637), Expect = 5e-65, Method: Compositional matrix adjust. Identities = 126/286 (44%), Positives = 183/286 (63%), Gaps = 24/286 (8%) Query: 3 QYLELMQK-VLDEGTQKNDRTGTGTLSIFGHQMRFNLQDG-FPLVTTKRCHLRSIIHELL 60 QYL+++++ +L + + +RTG GT+S FG+QM+++L++ FPL+TTKR + + EL Sbjct: 250 QYLDIIKELILSDINVREERTGVGTVSKFGYQMKYSLRNNVFPLLTTKRVFWKGVAKELF 309 Query: 61 WFLQGDTNIAYLHENNVTIWD-----EWADENG-------DLGPVYGKQWRAWPTP---- 104 WF+ G TN L E ++ IWD E+ D G DLGPVYG QWR W + Sbjct: 310 WFISGSTNAKILSEQDIHIWDGNGSREYLDSLGFENREEMDLGPVYGFQWRHWGSSYENM 369 Query: 105 ----DGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVAD--GK 158 + +DQ+ + LKN+P +RRII+SAWNV +L MAL PCH QF+V + Sbjct: 370 HTDYTNKGVDQLKKCIETLKNNPTNRRIILSAWNVSDLPNMALPPCHLMCQFWVDTDTNE 429 Query: 159 LSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHL 218 LSCQ+YQRSCD+ LG+PFNIASYALL +MAQ C+L+ GDF+ T GDTH+Y NH++ Sbjct: 430 LSCQMYQRSCDMGLGVPFNIASYALLTRLMAQVCNLKPGDFIHTLGDTHVYKNHIEPLKK 489 Query: 219 QLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 Q+ R+P+ P L++ +I D++FE ++ Y+PH IK +A+ Sbjct: 490 QIERDPKHFPLLLLDPSITNIDDFKFEHLTLQNYEPHATIKMEMAV 535 >UniRef50_Q6QGJ5 Putative thymidylate synthase n=1 Tax=Enterobacteria phage T5 RepID=Q6QGJ5_BPT5 Length = 279 Score = 249 bits (636), Expect = 7e-65, Method: Compositional matrix adjust. Identities = 138/286 (48%), Positives = 183/286 (63%), Gaps = 31/286 (10%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL 60 M+QYL+++ V+ G +NDRTGTGT+SIF +F+L++GFP VTTKR +S++ ELL Sbjct: 1 MQQYLKILTDVILLGEPRNDRTGTGTVSIFDSYAKFDLREGFPAVTTKRLAWKSVVGELL 60 Query: 61 WFLQGDTNIAYLH-------ENNVTIWD--------EWADENGDLGPVYGKQWRAWPTPD 105 WFL G TN+ L E TIW + G+LGPVYGKQWR + Sbjct: 61 WFLSGSTNLHDLRVFTFGRDEGQWTIWTPNYEDQAISMGYDKGNLGPVYGKQWRNF---G 117 Query: 106 GRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVA-DGKLSCQLY 164 GR DQI ++ LKN+P RR +VSAWNV ELDKMAL PCH FQ YV+ DG L + Sbjct: 118 GR--DQILELIEGLKNNPHGRRHLVSAWNVAELDKMALPPCHYGFQCYVSNDGYLDLKWT 175 Query: 165 QRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREP 224 QRS D FLGLPFNIASYALL H++A+ L+ +++GGDTH+Y++HM+Q Q+ R+P Sbjct: 176 QRSVDCFLGLPFNIASYALLTHILAKLTGLKPRYLIFSGGDTHIYNDHMEQVEEQVKRKP 235 Query: 225 RPLPKLIIKRKPESIFDYRFED-------FEIEGYDPHPGIKAPVA 263 RPLP L++ PE + Y + F +EGYDPHP +KA ++ Sbjct: 236 RPLPTLVM---PEFVDLYDLLENNTAAWSFHLEGYDPHPALKAKMS 278 >UniRef50_P00471 Thymidylate synthase n=17 Tax=T4-like viruses RepID=TYSY_BPT4 Length = 286 Score = 248 bits (633), Expect = 1e-64, Method: Compositional matrix adjust. Identities = 130/291 (44%), Positives = 186/291 (63%), Gaps = 32/291 (10%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL 60 MKQY +L++ + + G + +DRTGTGT+++FG ++R++L GFP VTTK+ ++ I EL+ Sbjct: 1 MKQYQDLIKDIFENGYETDDRTGTGTIALFGSKLRWDLTKGFPAVTTKKLAWKACIAELI 60 Query: 61 WFLQGDTNIAYL----HENNV---TIWDEWADE--------NGDLGPVYGKQWRAWPTPD 105 WFL G TN+ L H++ + T+WDE + +G+LGP+YGKQWR D Sbjct: 61 WFLSGSTNVNDLRLIQHDSLIQGKTVWDENYENQAKDLGYHSGELGPIYGKQWR-----D 115 Query: 106 GRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQ 165 +DQI V++++K P+ RR IVSAWN EL MAL PCH F+QF V +G L Q YQ Sbjct: 116 FGGVDQIIEVIDRIKKLPNDRRQIVSAWNPAELKYMALPPCHMFYQFNVRNGYLDLQWYQ 175 Query: 166 RSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPR 225 RS DVFLGLPFNIASYA LVH++A+ C+L GD +++GG+TH+Y NH++Q L REP+ Sbjct: 176 RSVDVFLGLPFNIASYATLVHIVAKMCNLIPGDLIFSGGNTHIYMNHVEQCKEILRREPK 235 Query: 226 PLPKLII------------KRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 L +L+I K + + + R +DF + Y HP IK +A+ Sbjct: 236 ELCELVISGLPYKFRYLSTKEQLKYVLKLRPKDFVLNNYVSHPPIKGKMAV 286 >UniRef50_Q8WYK3 Thymidylate synthase n=4 Tax=Eutheria RepID=Q8WYK3_HUMAN Length = 279 Score = 246 bits (628), Expect = 6e-64, Method: Compositional matrix adjust. Identities = 131/274 (47%), Positives = 166/274 (60%), Gaps = 38/274 (13%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62 QYL +Q +L G +K+DRTGTGTLS+FG Q R++L+D FPL+TTKR + ++ ELLWF Sbjct: 32 QYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWF 91 Query: 63 LQGDTNIAYLHENNVTIWDEWAD------------ENGDLGPVYGKQWRAWPTPDGRHID 110 ++G TN L V IWD E GDLGPVYG QWR Sbjct: 92 IKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEGDLGPVYGFQWR----------- 140 Query: 111 QITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDV 170 +++D L MAL PCHA QFYV + +LSCQLYQRS D+ Sbjct: 141 HFGAEYRDMESD---------------LPLMALPPCHALCQFYVVNSELSCQLYQRSGDM 185 Query: 171 FLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKL 230 LG+PFNIASYALL +M+A L+ GDF+ T GD H+Y NH++ +QL REPRP PKL Sbjct: 186 GLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKL 245 Query: 231 IIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 I RK E I D++ EDF+IEGY+PHP IK +A+ Sbjct: 246 RILRKVEKIDDFKAEDFQIEGYNPHPTIKMEMAV 279 >UniRef50_Q9UTI7 Probable thymidylate synthase n=17 Tax=cellular organisms RepID=TYSY_SCHPO Length = 625 Score = 239 bits (609), Expect = 9e-62, Method: Compositional matrix adjust. Identities = 129/295 (43%), Positives = 181/295 (61%), Gaps = 32/295 (10%) Query: 2 KQYLELMQKVLDEGTQKNDRTGTGTLSIFGH-QMRFNLQDG-FPLVTTKRCHLRSIIHEL 59 +QYL L++ +L+ G + DRTGTGT S+F Q+RF+L++ PL+TTKR LR ++ EL Sbjct: 331 EQYLNLIRYILENGQSRPDRTGTGTRSVFAPPQLRFSLRNNTLPLLTTKRVFLRGVLEEL 390 Query: 60 LWFLQGDTNIAYLHENNVTIWD-----EWADENG-------DLGPVYGKQWRAWPTP--- 104 LWF+ GDTN +L E + IWD E+ D G DLGP+YG QWR + Sbjct: 391 LWFIHGDTNANHLSEKGIHIWDGNGSREFLDSRGLTDRKVGDLGPIYGFQWRHFGAQYVD 450 Query: 105 -----DGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVAD--- 156 + +DQ+ V++ LK +P RRII+SAWN + +MAL PCH F QFYV++ Sbjct: 451 CDTDYTNKGVDQLAQVISTLKLNPYDRRIILSAWNPLAIPEMALPPCHIFCQFYVSEPCK 510 Query: 157 --GK--LSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNH 212 GK LS +YQRS D+ LG+PFNIASY+LL HM+A C E +FV GD H+Y++H Sbjct: 511 PGGKPQLSSMMYQRSADMGLGVPFNIASYSLLTHMIAHMCGYEAAEFVHVMGDCHIYNDH 570 Query: 213 MDQTHLQLSREPRPLPKLIIKRKPE---SIFDYRFEDFEIEGYDPHPGIKAPVAI 264 ++ QL R P+ PKL KR + SI + +DF +EGY+P+ IK +++ Sbjct: 571 LEALQTQLERVPKAFPKLFFKRDAKDIGSIDSFSVDDFAVEGYNPYGPIKMKMSV 625 >UniRef50_Q4PBV6 Thymidylate synthase n=3 Tax=Dikarya RepID=Q4PBV6_USTMA Length = 554 Score = 230 bits (587), Expect = 4e-59, Method: Compositional matrix adjust. Identities = 129/295 (43%), Positives = 183/295 (62%), Gaps = 33/295 (11%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQ--MRFNLQDG-FPLVTTKRCHLRSIIHEL 59 QYLEL+Q+V+ G + DRTGTGTL++F Q +RF+L +G PL+TTKR R ++ EL Sbjct: 260 QYLELVQRVISTGESRPDRTGTGTLALFAPQPSLRFDLTNGTLPLLTTKRVFFRGVLEEL 319 Query: 60 LWFLQGDTNIAYLHENNVTIWDEWADE------------NGDLGPVYGKQWRAWPTP--- 104 LWF+ G T+ L E +V IWD GDLGPVYG QWR + Sbjct: 320 LWFVGGKTDAKLLTEKSVHIWDGNGSRAFLDSRGLSHRREGDLGPVYGFQWRHFGATYKD 379 Query: 105 -----DGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVAD--- 156 G+ +DQ+ +V+++++N+P RRI++SAWN +L+ MAL PCH F QF+V++ Sbjct: 380 CDTDYAGQGVDQLASVIDKIRNNPTDRRILLSAWNPADLELMALPPCHMFAQFFVSNLDA 439 Query: 157 -----GK--LSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLY 209 GK LSCQ+YQRSCD+ LG+PFNIASYALL +M+A+ D E + + GD H+Y Sbjct: 440 YSKGQGKKHLSCQMYQRSCDLGLGVPFNIASYALLTYMIAKVTDCEPKELILAMGDAHVY 499 Query: 210 SNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 +H+ QL R+P P PKL I+R + I D+ F+DF ++GY H I +++ Sbjct: 500 KDHVQPLKAQLERDPLPFPKLKIERDVKDIDDFTFDDFVVQGYKCHGKIDMKMSV 554 >UniRef50_A2R2F6 Thymidylate synthase n=20 Tax=Leotiomyceta RepID=A2R2F6_ASPNC Length = 356 Score = 226 bits (577), Expect = 5e-58, Method: Compositional matrix adjust. Identities = 133/318 (41%), Positives = 177/318 (55%), Gaps = 56/318 (17%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGH-QMRFNLQDG--------------FPLVTT 47 QYL L++++L EG + DRTGTGT SIF QMRF+L PL+TT Sbjct: 39 QYLNLIRRILSEGEHRPDRTGTGTRSIFAPPQMRFSLSKPSTNTTTGIKEYTPILPLLTT 98 Query: 48 KRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWD-----EWAD-------ENGDLGPVYG 95 KR LR+++ ELLWF+ G T+ L E + IWD E+ D E GDLGPVYG Sbjct: 99 KRVFLRAVLAELLWFISGTTSSLPLSEAGIKIWDGNGSREYLDKVGLSHREVGDLGPVYG 158 Query: 96 KQWRAWPTP--------DGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCH 147 QWR + G+ +DQ+ V+ +LK +P RRII+SAWN ++ MAL PCH Sbjct: 159 FQWRHFGAEYVDAKTDYSGQGVDQLAEVVKKLKENPFDRRIIMSAWNPKDMRIMALPPCH 218 Query: 148 AFFQFYV------------------ADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMA 189 F QFYV G L C LYQRS D+ LG+PFNIASYALL H++A Sbjct: 219 MFAQFYVRFPDAKRDEEGVVRDGEWGRGHLDCLLYQRSADMGLGVPFNIASYALLTHLLA 278 Query: 190 QQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKR--KPESIFD-YRFED 246 D+ G V T GD H+Y +H+D Q+ REP P++ IKR + + D ++ E+ Sbjct: 279 HAVDMVPGTLVHTLGDAHVYLDHVDALKEQIEREPVAFPEVRIKREDRGSGVVDGWKEEE 338 Query: 247 FEIEGYDPHPGIKAPVAI 264 FE+ GY PH IK +++ Sbjct: 339 FEVIGYKPHKAIKMKMSV 356 >UniRef50_D2XB64 Bifunctional dihydrofolate reductase-thymidylate synthase n=1 Tax=Marseillevirus RepID=D2XB64_9VIRU Length = 444 Score = 222 bits (566), Expect = 8e-57, Method: Compositional matrix adjust. Identities = 113/280 (40%), Positives = 162/280 (57%), Gaps = 20/280 (7%) Query: 4 YLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRF-NLQDGFPLVTTKRCHLRSIIHELLWF 62 YL L+ +VL G ++ DRTGTGT S+FG + F N+ + FPL+T KR I+ ELLWF Sbjct: 164 YLSLLSEVLYSGEKRKDRTGTGTRSLFGRHLLFENISEKFPLITVKRMAWGCILSELLWF 223 Query: 63 LQGDTNIAYLHENNVTIWDEWADEN-----------GDLGPVYGKQWRAWPTP------- 104 L G T+ L N IW + + GD GP+YG QWR W Sbjct: 224 LSGSTDSKMLELQNNNIWKKNSSRKFLDGRGLSYREGDCGPIYGFQWRHWGAKYVDCDTD 283 Query: 105 -DGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQL 163 G+ DQI +++++++N+ SRR+++SAWNV +LDKM L PCH+F QFYV + C L Sbjct: 284 YRGQGEDQILSIISEIQNNATSRRLVLSAWNVSDLDKMCLPPCHSFSQFYVRGDFVDCHL 343 Query: 164 YQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSRE 223 YQRS D+ LG+PFNIASYA L+ ++A+ + G+ + GD H+Y H+D L R Sbjct: 344 YQRSADLALGVPFNIASYACLLSIIAEASGKKAGNLTMSFGDVHIYETHIDNAQKMLERL 403 Query: 224 PRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263 P PKL +K ++F + DFE++GY ++ +A Sbjct: 404 PHKTPKLKVKISDNTLFCLKKGDFELDGYSCCGALQFDMA 443 >UniRef50_Q76YC2 DTMP synthase n=1 Tax=Aeromonas phage Aeh1 RepID=Q76YC2_9CAUD Length = 277 Score = 222 bits (566), Expect = 9e-57, Method: Compositional matrix adjust. Identities = 119/282 (42%), Positives = 161/282 (57%), Gaps = 23/282 (8%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL 60 MK YL+++ + G + DRTG GT S+ G R ++ DGFP VTTK +++ E L Sbjct: 1 MKAYLDIINYTFENGEDEMDRTGVGTRSVLGQVFRHDMADGFPAVTTKTLAWKAVRGECL 60 Query: 61 WFLQGDTNIAYLH-------ENNVTIWDEWADE--------NGDLGPVYGKQWRAWPTPD 105 WF+ G TN+ L ++ TIWD+ + +G+LGPVYGKQWR D Sbjct: 61 WFMNGFTNVEVLRAMTYGVGSSSKTIWDDNFNHQGVALGYTDGELGPVYGKQWR-----D 115 Query: 106 GRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQ 165 +DQ+ + ++K +P+ RR IV AWN +LDKMAL PCH F+F V G+L+ YQ Sbjct: 116 FNGVDQLAKAIERIKTNPECRRNIVCAWNPVDLDKMALPPCHVLFRFSVKRGRLNLTWYQ 175 Query: 166 RSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPR 225 RS D FLGLPFNIASY LL+ ++AQ + G DTH+Y NH +Q QL REP Sbjct: 176 RSVDTFLGLPFNIASYGLLLEIVAQITGYKAGILTGMLDDTHIYHNHFEQVQEQLQREPH 235 Query: 226 PLPKLIIKRK---PESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 LP L K + E + +D E+E Y H IKAP+A+ Sbjct: 236 KLPTLKFKNRFTTLEEACNLSVDDIELEDYKCHSAIKAPMAV 277 >UniRef50_A3QU09 Thymidylate synthase n=1 Tax=Oryctes rhinoceros virus RepID=A3QU09_9VIRU Length = 321 Score = 218 bits (555), Expect = 2e-55, Method: Compositional matrix adjust. Identities = 125/294 (42%), Positives = 171/294 (58%), Gaps = 33/294 (11%) Query: 2 KQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDG-FPLVTTKRCHLRSIIHELL 60 + YL L++ VL + N RTG S FGHQ+RF+L++G PL+TTK ++I+ EL Sbjct: 30 RNYLSLVRTVLKAPSSPN-RTGIDARSSFGHQLRFDLRNGVLPLLTTKPMPFKTILRELF 88 Query: 61 WFLQGDTNIAYLHENNVTIWD-----EWADENG--------DLGPVYGKQWRAWPTP--- 104 WFL+G+TN L NV IW E+ D G LGP+YG QWR + Sbjct: 89 WFLRGETNQKILERQNVHIWKGNSSREYLDSRGLYDYTEYESLGPIYGFQWRHFGASYVD 148 Query: 105 -----DGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYV--ADG 157 + +DQ+ V+ +K DP SRRII+SAWN +LDKMAL PCH QF+V +G Sbjct: 149 CNTDYTNKGVDQLQQVIRTIKEDPTSRRIIMSAWNPVDLDKMALPPCHILVQFHVNTVNG 208 Query: 158 KLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTH 217 +LS QLYQRS D+ LG+PFNIASY++LVH++A+ C L+ G F+ + GD H+Y NH+ Sbjct: 209 ELSAQLYQRSADLMLGVPFNIASYSILVHLIAKICGLKPGYFIHSLGDVHIYENHVSGAK 268 Query: 218 LQLSREPRPLPKLIIKRKPESIFDYRFEDFEIE-------GYDPHPGIKAPVAI 264 QL+REP+ P L I P D E + Y+P+P IK +A+ Sbjct: 269 EQLTREPQRQPYLNIDIDPTLDLDSILEQLSCDQFKLVNYKYNPNP-IKLEMAV 321 >UniRef50_UPI0001925B1E PREDICTED: similar to thymidylate synthase, partial n=1 Tax=Hydra magnipapillata RepID=UPI0001925B1E Length = 197 Score = 206 bits (525), Expect = 5e-52, Method: Compositional matrix adjust. Identities = 106/241 (43%), Positives = 144/241 (59%), Gaps = 44/241 (18%) Query: 24 TGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEW 83 TGTLSIFG QMRFNL++ FPL+TTKR + ++ ELLWF+ G T+ L + V IW+ Sbjct: 1 TGTLSIFGGQMRFNLRESFPLLTTKRVFWKGVVEELLWFISGSTDGNILAQKGVQIWNS- 59 Query: 84 ADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMAL 143 + R + N+ MAL Sbjct: 60 ----------------------------------------NGTREFLDKCNI---PLMAL 76 Query: 144 APCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTG 203 PCH+F QFYVA+G+LSCQ+YQRSCD+ LG+PFNIASY+LL +++A C+L+ GDF+ T Sbjct: 77 PPCHSFCQFYVANGELSCQMYQRSCDMGLGIPFNIASYSLLTYIIAHVCNLKPGDFIHTL 136 Query: 204 GDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263 GD H+Y+NH+ Q+ R PRP PKL IKRK E+I D++ +DFE+ GY+PH IK +A Sbjct: 137 GDAHVYNNHVSALKEQIGRSPRPFPKLNIKRKVENIDDFKSDDFELIGYNPHQKIKMAMA 196 Query: 264 I 264 + Sbjct: 197 V 197 >UniRef50_Q5UQG3 Thymidylate synthase n=1 Tax=Acanthamoeba polyphaga mimivirus RepID=DRTS_MIMIV Length = 563 Score = 203 bits (517), Expect = 5e-51, Method: Compositional matrix adjust. Identities = 108/291 (37%), Positives = 166/291 (57%), Gaps = 34/291 (11%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62 QY+EL++ ++++G K R T SIFG+Q++++L G+P+ T KR + ++I EL+W Sbjct: 274 QYIELVKTIMEKGIVKQTRNSI-TKSIFGYQLKYDLSKGYPIQTIKRSYPKAIFEELMWM 332 Query: 63 LQGDTNIAYLHENNVTIWDEWAD-----------ENGDLGPVYGKQWRAW--------PT 103 ++G T+++ L + V +WD+ + E GD+GP YG Q R W + Sbjct: 333 IRGQTDVSILQKKGVHVWDKNSSKDFLSKYNLPYEEGDIGPGYGFQMRYWGAEYTDCKTS 392 Query: 104 PDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYV--------- 154 G+ IDQ+ + ++N+P RRI+++ WN +LDKMALAPCH + F V Sbjct: 393 YQGQGIDQLNKCIESIQNNPHDRRIMINLWNCSDLDKMALAPCHFCYMFGVDLYEVPTTS 452 Query: 155 -ADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHM 213 G+L+C L QRS DV LG +N + ALL +++A CDL+ G V + D H+Y +H+ Sbjct: 453 GKKGRLNCHLVQRSWDVLLG--WNTTTAALLTYLIANHCDLDPGILVHSISDAHIYQSHI 510 Query: 214 DQTHLQ--LSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPV 262 D + L R+ R P L+I+ K E I DY F+D IE Y P P I A + Sbjct: 511 DSGAISQLLQRKCRKFPNLVIRNKKEKIDDYEFDDLIIENYYPCPSISAEM 561 >UniRef50_B2YFY9 Thymidylate synthase n=1 Tax=Musca domestica salivary gland hypertrophy virus RepID=B2YFY9_9VIRU Length = 294 Score = 202 bits (513), Expect = 1e-50, Method: Compositional matrix adjust. Identities = 109/286 (38%), Positives = 172/286 (60%), Gaps = 24/286 (8%) Query: 2 KQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDG-FPLVTTKRCHLRSIIHELL 60 + YL L+++VL +GT K++RTG T IFG Q+R++L+D ++TTK+ RS + ELL Sbjct: 8 RGYLTLVRRVLRDGTLKSNRTGVDTKYIFGDQLRYDLRDNRIAMLTTKKVFFRSALEELL 67 Query: 61 WFLQGDTNIAYLHENNVTIWD-----EWAD-------ENGDLGPVYGKQWRAWPTP---- 104 WFL+GDTN A L V IW E+ D E+ LGP+YG QWR + Sbjct: 68 WFLRGDTNQANLAAKGVNIWRGNSTREYLDSRKLPYPEHESLGPIYGFQWRHFGARYIDC 127 Query: 105 ----DGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVAD--GK 158 G+ +DQ+ ++Q++ +P SRR+I++AWN +LDKM L PCH QF V + G+ Sbjct: 128 HTDYTGQGVDQLAQCMHQIQYEPSSRRMIMTAWNPNDLDKMVLPPCHMSIQFSVNEKLGE 187 Query: 159 LSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHL 218 LS + QRS D+ LG+PFN+ SY+L++H++A + L+ G+ V + GD H+Y H+ Sbjct: 188 LSGHMTQRSADLMLGVPFNLVSYSLMLHILAHKFGLKAGELVTSYGDLHIYVPHIKNAMR 247 Query: 219 QLSREPRPLPKLIIK-RKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263 Q+SR P P++ +K + + + + +DF ++ Y H ++ +A Sbjct: 248 QVSRLPYASPQIELKFGRDKRVEELTVDDFAVKNYRHHSQLEYEMA 293 >UniRef50_A9UZA9 Thymidylate synthase n=1 Tax=Monosiga brevicollis RepID=A9UZA9_MONBE Length = 398 Score = 199 bits (507), Expect = 5e-50, Method: Compositional matrix adjust. Identities = 111/244 (45%), Positives = 138/244 (56%), Gaps = 45/244 (18%) Query: 66 DTNIAYLHENNVTIWDEWAD------------ENGDLGPVYGKQWRAWPTP--------D 105 +TN L +V IWD E GDLGPVYG QWR + Sbjct: 33 NTNANDLAARDVHIWDANGSKDFLEKQGLGHREEGDLGPVYGFQWRHFGAEYKDMHTDYS 92 Query: 106 GRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQ 165 G+ +DQ+ V+ Q+K +PDSRRII+SAWN ++ KMAL PCH QFYV DG+LSCQLYQ Sbjct: 93 GQGVDQLAEVIEQIKTNPDSRRIIMSAWNPLDIPKMALPPCHTMCQFYVCDGELSCQLYQ 152 Query: 166 RSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPR 225 RS D+ LG+PFNIASYALL +M+AQ L+ GDFV T GD H+Y NH+D QL REPR Sbjct: 153 RSADMGLGVPFNIASYALLTYMIAQVTGLKPGDFVHTIGDAHVYLNHVDALEEQLKREPR 212 Query: 226 PLPKLIIKRKPE-------------------------SIFDYRFEDFEIEGYDPHPGIKA 260 P P L KR E I D++FEDF+++GY PH I Sbjct: 213 PFPTLSFKRDIEEYVHAFGQHVTNPLEHRPTAALLSLGIDDFKFEDFDLQGYKPHNRIAM 272 Query: 261 PVAI 264 +A+ Sbjct: 273 DMAM 276 >UniRef50_Q6WIC0 DTMP (Thymidylate) synthase n=1 Tax=Vibrio phage KVP40 RepID=Q6WIC0_BPKV4 Length = 300 Score = 199 bits (505), Expect = 1e-49, Method: Compositional matrix adjust. Identities = 120/303 (39%), Positives = 169/303 (55%), Gaps = 44/303 (14%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL 60 MK YL+L ++L+EG +RTGT T+S+ ++R++L GFPL+TTK+ ++I ELL Sbjct: 2 MKNYLQLCTEILNEGDFLENRTGTNTVSVISRELRWDLSKGFPLLTTKKMATKAIFGELL 61 Query: 61 WFLQGDTNIA------YLHENNVTIWDEWADE-------------NGDLGPVYGKQWRAW 101 WFL G I+ L + + IW + DE DLG VYGK WR Sbjct: 62 WFLSGSGLISDLRKYTELSDEDFCIWQQNLDELNERAKKAGIVRNEDDLGYVYGKVWRKR 121 Query: 102 --PTPDGR-----HIDQITTVLNQLKNDPDS---RRIIVSAWN------VGELDKMALAP 145 T D I Q+ + +K DP RR+IV AW+ +D +AL P Sbjct: 122 LSVTADKEVTEFDQIHQLLCDIAAVKEDPTQSAQRRMIVEAWDPYFHTESNSVD-VALPP 180 Query: 146 CHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGD 205 CH FQ +V +GK+S + QRS D FLGLPFNIASYALLVH++AQ L+VG+ +++GGD Sbjct: 181 CHYGFQVFVRNGKISLKWNQRSVDTFLGLPFNIASYALLVHILAQLTGLKVGELIFSGGD 240 Query: 206 THLYSNHMDQTHLQLSREPRPLPKLIIKRKPE-----SIFDYRFEDFEIEGYDPHPGIKA 260 H+Y +H+ Q QL R PR LP++ + PE + R DF + YDP+P +K Sbjct: 241 VHIYEDHIVQVLKQLRRTPRELPQIQL---PEFDTLSQLLTKRASDFVVYDYDPYPALKG 297 Query: 261 PVA 263 ++ Sbjct: 298 KMS 300 >UniRef50_Q88CN9 Thymidylate synthase n=74 Tax=Proteobacteria RepID=TYSY_PSEPK Length = 323 Score = 197 bits (501), Expect = 3e-49, Method: Compositional matrix adjust. Identities = 116/323 (35%), Positives = 165/323 (51%), Gaps = 59/323 (18%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL 60 MKQYL+L++ V+D GT + +RTG T+S+ G +RF+LQ GFP +TT++ +S I E++ Sbjct: 1 MKQYLDLVRDVIDNGTLQGNRTGIRTISLPGAMLRFDLQKGFPAITTRKLAFKSAIGEMV 60 Query: 61 WFLQGDTNIAYLHENNVTIWDEWADENG------------DLGPVYGKQWRAWP------ 102 FL+G N E +WD+ A+EN DLG +YG QWR WP Sbjct: 61 GFLRGVKNAGEFRELGCKVWDQNANENAQWLANPFRQGHDDLGEIYGVQWRQWPGYKRIP 120 Query: 103 ---------------------TPDG-------RHIDQITTVLNQLKNDPDSRRIIVSAWN 134 DG + IDQ+ L+ + NDP SRRI+ WN Sbjct: 121 LSNPAAIEMAEQAGFRRIAQDEEDGVAFVILYKAIDQVRQCLDTIANDPGSRRILFHGWN 180 Query: 135 VGELDKMALAPCHAFFQFY--VADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQC 192 +LD+MAL PCH +QF+ V ++S LY RS D+ LG PFN+ A L+ + + Sbjct: 181 CAQLDEMALPPCHLLYQFHPNVETREISLTLYIRSNDLGLGTPFNLTEGAALLSLFGRLT 240 Query: 193 DLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLII-----------KRKPESIFD 241 F + GD H+Y NH+D + QL REP PKL+I K +PE + Sbjct: 241 GYTPRWFTYFIGDAHVYENHLDMLNEQLKREPLEAPKLVISDRVPAFAETGKYEPEWLEK 300 Query: 242 YRFEDFEIEGYDPHPGIKAPVAI 264 DF +EGY+ H + AP+A+ Sbjct: 301 IEPSDFWLEGYEHHAPMTAPMAV 323 >UniRef50_D1BNV6 Thymidylate synthase n=4 Tax=Veillonellaceae RepID=D1BNV6_VEIPT Length = 263 Score = 192 bits (488), Expect = 1e-47, Method: Compositional matrix adjust. Identities = 102/265 (38%), Positives = 152/265 (57%), Gaps = 11/265 (4%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62 QYL +++ +LD G +RTG T + M+F+LQ+ FP++TTK ++ + ELLW Sbjct: 7 QYLGIIENILDHGIYGQNRTGIATYKLPQQIMQFDLQEEFPILTTKFVAFKTAVKELLWI 66 Query: 63 LQGDTN-IAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKN 121 Q +N + L E NV +WDEW E+G +G YG Q + Q+ ++ +K Sbjct: 67 WQMQSNDVRKLQEMNVHVWDEWMREDGTIGKAYGYQIAKYK--------QLDKLIKTIKE 118 Query: 122 DPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASY 181 DPDSRR+IV+ WN+ +LD MAL PC + V DG L+C L QRS D+ LG+PFN A Y Sbjct: 119 DPDSRRMIVTLWNIEDLDDMALQPCAYETLWDVGDGYLNCMLIQRSGDMGLGVPFNTAQY 178 Query: 182 ALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSR--EPRPLPKLIIKRKPESI 239 A L M+AQ L+ G F + H+Y NH+D QL+R + P PK+I+ + + Sbjct: 179 AALQCMIAQVTGLKPGKFTHVINNAHIYENHVDALREQLARRNQALPAPKIIVNPEVKDF 238 Query: 240 FDYRFEDFEIEGYDPHPGIKAPVAI 264 +D+ ED ++GY+ + VA+ Sbjct: 239 YDFTPEDITLDGYEHLGKLSMTVAV 263 >UniRef50_Q934U8 Putative thymidylate synthase n=1 Tax=Salmonella enterica subsp. enterica serovar Typhi RepID=Q934U8_SALTI Length = 371 Score = 192 bits (487), Expect = 1e-47, Method: Compositional matrix adjust. Identities = 118/351 (33%), Positives = 162/351 (46%), Gaps = 90/351 (25%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDG-FPLVTTKRCHLRSIIHELLW 61 Y ++++ VL+ G DRTGTGT S+ + L G PL++ K +L+ ++ EL W Sbjct: 22 SYAKVVETVLNSGVHAGDRTGTGTKSVSYVPSYYMLTGGSVPLISGKAVNLKPLLVELEW 81 Query: 62 FLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPD---------------- 105 +L+G NI +L +N V IWD WADENGDLGPVYGKQWR W Sbjct: 82 YLKGTGNIQFLKDNGVKIWDAWADENGDLGPVYGKQWRRWEDTRIVSHSEYLSKIDTFRE 141 Query: 106 ------------------GRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCH 147 R IDQ+ +++ L+ +P RRI+++AWNVGEL+ M L PCH Sbjct: 142 RGYKVEGYLGVSEDRVVLSREIDQLQRIVHTLRTNPTDRRILLNAWNVGELEDMKLPPCH 201 Query: 148 AFFQFYV------------------------------------ADGKL------------ 159 F + DG + Sbjct: 202 FVFSLWSRKLDFETRLTMATDIGIQHNRHGHESIYTQMLCLLERDGGITENLLDELGIPK 261 Query: 160 ----SCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQ 215 SC L QRS D F+G+PFNIA Y +L H +A+ G FV G D HLY NHM Sbjct: 262 RILNSC-LVQRSVDTFVGMPFNIAGYGILTHFLAKITGHMAGAFVHFGFDVHLYDNHMGG 320 Query: 216 THLQLSREP--RPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 + REP P +I + + D+++E ++ GY P P IK PVA+ Sbjct: 321 VEELMKREPPKESDPVVIFPHEWAELDDFKWEGVQVCGYSPLPWIKVPVAV 371 >UniRef50_Q8WYK4 Thymidylate synthase n=7 Tax=Fungi/Metazoa group RepID=Q8WYK4_HUMAN Length = 230 Score = 192 bits (487), Expect = 1e-47, Method: Compositional matrix adjust. Identities = 94/173 (54%), Positives = 123/173 (71%), Gaps = 1/173 (0%) Query: 93 VYGKQWR-AWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQ 151 V+G Q R + G+ +DQ+ V++ +K +PD RRII+ AWN +L MAL PCHA Q Sbjct: 58 VFGMQARYSLRDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALCQ 117 Query: 152 FYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSN 211 FYV + +LSCQLYQRS D+ LG+PFNIASYALL +M+A L+ GDF+ T GD H+Y N Sbjct: 118 FYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLN 177 Query: 212 HMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 H++ +QL REPRP PKL I RK E I D++ EDF+IEGY+PHP IK +A+ Sbjct: 178 HIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPHPTIKMEMAV 230 Score = 49.7 bits (117), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 22/38 (57%), Positives = 30/38 (78%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQD 40 QYL +Q +L G +K+DRTGTGTLS+FG Q R++L+D Sbjct: 32 QYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRD 69 >UniRef50_D2RRK7 Thymidylate synthase n=9 Tax=cellular organisms RepID=D2RRK7_9EURY Length = 338 Score = 185 bits (469), Expect = 2e-45, Method: Compositional matrix adjust. Identities = 120/340 (35%), Positives = 162/340 (47%), Gaps = 80/340 (23%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRC---HLRSIIH 57 M+QYLEL+ VL EGT K +RTG T+S F +LQDG+PL+TTK+ S++H Sbjct: 1 MRQYLELVDTVLSEGTYKPNRTGVDTISSFSEHYEVDLQDGYPLLTTKQMDGYRWNSMLH 60 Query: 58 ELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTP------------- 104 E+ W+L G+ +I L E IWD WAD+ G L YG+ WR +P P Sbjct: 61 EVCWYLSGEEHIRDLREE-TKIWDAWADDEGRLDTAYGRFWRRFPIPEDDAQLEGESWPD 119 Query: 105 ----------DGRH-IDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFY 153 DGR DQ+ V++ L + P+SRR++V+AW+ L PCH F F Sbjct: 120 ETHQWVTEEADGRRTFDQLQYVIDTLSDSPNSRRLVVNAWHPANAAVSTLPPCHYSFVFN 179 Query: 154 VADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHM 213 +L+C L QRS D LG+PFNIA+YALL ++AQQ + G F T DTH+Y Sbjct: 180 AQGDRLNCHLTQRSGDTALGIPFNIAAYALLTKVIAQQTGFKPGTFAHTVVDTHVYCGRG 239 Query: 214 D------------QTHL--------------------------------------QLSRE 223 D Q+ L QLSRE Sbjct: 240 DRGEWYADNLETLQSRLNDVEDREDYLEVKSWLESAAPDEAEGDERLDHVPGLLEQLSRE 299 Query: 224 PRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263 P P L + SI + +ED E++ Y+ H GI+ VA Sbjct: 300 PLERPTLEVADV--SIDELAYEDVELKNYESHEGIEFAVA 337 >UniRef50_A6M378 Thymidylate synthase n=8 Tax=Clostridium RepID=TYSY_CLOB8 Length = 263 Score = 181 bits (459), Expect = 2e-44, Method: Compositional matrix adjust. Identities = 98/265 (36%), Positives = 148/265 (55%), Gaps = 11/265 (4%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62 +YL + +L+ G N+RTG T + M+FNL+ FP++TTK ++ + ELLW Sbjct: 7 KYLAIANDILENGYFDNNRTGVKTYKLPHQIMQFNLEKEFPILTTKFVAFKTAVKELLWI 66 Query: 63 LQGDTN-IAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKN 121 + +N + L NV IWDEW E+G +G YG W + DQI +++ LKN Sbjct: 67 FKDQSNSVKELQSQNVKIWDEWMMEDGTIGTSYG--WIV------KKFDQIDKLIDALKN 118 Query: 122 DPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASY 181 +P RR++++ W + LD L PC + V DGKL+C L QRS D LG+PFN + Y Sbjct: 119 NPQDRRMMINLWQIPYLDSAPLYPCCFLTMWDVTDGKLNCMLVQRSGDWGLGVPFNTSQY 178 Query: 182 ALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSR--EPRPLPKLIIKRKPESI 239 A+LVH++AQ L+ G F + H+Y N +D LQL+R + PKL I + + Sbjct: 179 AVLVHLLAQVTGLKPGLFTHVINNAHIYENQVDGLKLQLTRKNDAYNAPKLWINPEITNF 238 Query: 240 FDYRFEDFEIEGYDPHPGIKAPVAI 264 +D+ +D ++E Y H IK V++ Sbjct: 239 YDFTPDDIKLEDYKHHESIKMDVSV 263 >UniRef50_Q65J44 Thymidylate synthase n=9 Tax=root RepID=TYSY_BACLD Length = 279 Score = 179 bits (453), Expect = 1e-43, Method: Compositional matrix adjust. Identities = 99/275 (36%), Positives = 160/275 (58%), Gaps = 13/275 (4%) Query: 2 KQYLELMQKVLDEGTQK----------NDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCH 51 +QY ++QK+++ G +D T TLSI +MRF+ + P++TTK+ Sbjct: 6 QQYNAIIQKIIESGISDEEYQVRTKWDSDGTPAHTLSIMSEKMRFDNSE-VPILTTKKVA 64 Query: 52 LRSIIHELLWFLQGDTN-IAYLHENNVTIWDEWADENGDLGPVYGKQW-RAWPTPDGRHI 109 ++ I ELLW Q +N + L++ V IWD+W E+G +G YG Q + T +G+ + Sbjct: 65 WKTAIKELLWIWQLKSNDVQVLNDMGVHIWDQWRLEDGTIGAAYGYQLGKKNRTVNGQKV 124 Query: 110 DQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCD 169 DQ+ +L+QLK++P SRR + WN +LD MAL PC Q+YV +GKLS ++ RS D Sbjct: 125 DQVDYLLHQLKHNPSSRRHLTMLWNPDDLDGMALTPCVYETQWYVKEGKLSLEVRARSND 184 Query: 170 VFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPK 229 + LG PFN+ Y +L M+AQ E+G++++ GD H+Y+ H+D ++Q+ RE PK Sbjct: 185 MALGNPFNVFQYNVLQRMIAQVLGYELGEYIFNIGDCHIYTRHIDNLNIQMKREQYEAPK 244 Query: 230 LIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 L I ++ +D+ +DF++ Y + VA+ Sbjct: 245 LWINPDIKNFYDFTIDDFKLIDYKHGDKLTFEVAV 279 >UniRef50_B9LR89 Thymidylate synthase n=4 Tax=Halobacteriaceae RepID=B9LR89_HALLT Length = 342 Score = 172 bits (435), Expect = 1e-41, Method: Compositional matrix adjust. Identities = 119/344 (34%), Positives = 161/344 (46%), Gaps = 84/344 (24%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRC---HLRSIIH 57 M+QYL+L+ L GT K +RTG T++ F Q +L +GFPL+TTK+ S+IH Sbjct: 1 MQQYLDLVDDTLSTGTYKPNRTGVDTIATFSGQYTVDLSEGFPLLTTKKMDGYRWNSLIH 60 Query: 58 ELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDG----------- 106 E+LW+L G+ +I L E IWD WAD+ G L YG+ WR +P PDG Sbjct: 61 EVLWYLSGEEHIRDLREE-TKIWDAWADDEGRLDTAYGRFWRRFPVPDGVDALPGETWPK 119 Query: 107 -----------------RHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAF 149 R DQI VL+ L +P SRR++V+AW+ L PCH Sbjct: 120 DAHRWVTVEEGPEGVERRTFDQIQYVLDTLDENPRSRRMVVNAWHPANAAVSTLPPCHYT 179 Query: 150 FQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLY 209 F V DG+L+ L QRS D+ LG+PFNIA+YALL + +AQ+ E+G+F T D H+Y Sbjct: 180 FVVNVQDGRLNLHLTQRSGDIALGVPFNIAAYALLANALAQRTGFEIGEFGHTVVDAHIY 239 Query: 210 SNHMDQTHL--------------------------------------------------Q 219 D+ Q Sbjct: 240 CGRGDRGQWYANNLRYVQDRLATVESKADYLDVKSWVERTAPDEADGEERYDHVPGLLEQ 299 Query: 220 LSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263 LSREPR P++ I KP + + +ED E+ YD GI VA Sbjct: 300 LSREPRERPRIEIADKP--LDELTYEDIEVVDYDSADGISFAVA 341 >UniRef50_Q7Y427 dTMP (Thymidylate) synthase n=3 Tax=unclassified T4-like viruses RepID=Q7Y427_9CAUD Length = 410 Score = 166 bits (419), Expect = 9e-40, Method: Compositional matrix adjust. Identities = 78/157 (49%), Positives = 104/157 (66%), Gaps = 2/157 (1%) Query: 110 DQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCD 169 DQ+ V+ Q+KN+P RRII+ +WNV L CH F QFYV +GKLSC +QRS D Sbjct: 254 DQLQNVIEQIKNNPTDRRIIIDSWNVQGTHNAVLGVCHPFVQFYVNEGKLSCMWFQRSVD 313 Query: 170 VFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREP--RPL 227 FLGLPFN+ASYALL H++A+ CDLEVG+ +++GGDTH+Y NH DQ QLSR P +P Sbjct: 314 SFLGLPFNVASYALLTHIIAKMCDLEVGELIFSGGDTHIYKNHFDQVMEQLSRVPFDKPT 373 Query: 228 PKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 +L + + + +DF+I Y HP I A +A+ Sbjct: 374 IELPEFKSLDEVLTKTPKDFKIHNYQSHPAITAQMAV 410 Score = 85.1 bits (209), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 50/120 (41%), Positives = 68/120 (56%), Gaps = 18/120 (15%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL 60 MK+YL+L++ VLD G + DRTG GTLS FG +MR +L GFPL+TTK+ S+I ELL Sbjct: 1 MKEYLKLLRDVLDNGWPREDRTGVGTLSKFGAEMRIDLSKGFPLLTTKKMATASVIGELL 60 Query: 61 WFLQGDTNIAYLHENNVTIWDEWADE-----------------NG-DLGPVYGKQWRAWP 102 WF++G + L E +DE A + NG ++G +YG WR P Sbjct: 61 WFMEGSLDRRRLQEITRGKFDEEAFDIWRGNCLDMKEKNPLRFNGYNVGNMYGMAWRRKP 120 >UniRef50_C5H7L6 Thymidylate synthase n=3 Tax=unclassified Myoviridae RepID=C5H7L6_9CAUD Length = 299 Score = 158 bits (400), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 93/292 (31%), Positives = 147/292 (50%), Gaps = 29/292 (9%) Query: 2 KQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLW 61 Y ++ VL G + RTG + + RF+++ GFPL+T+K+ R +I E LW Sbjct: 6 SSYKNILNHVLSVGELRTTRTGDVISAFAPPKFRFDMRTGFPLLTSKQVFTRQVIGEALW 65 Query: 62 FLQGDTNIAYLH-----ENNVTIWDEWADE----------------NGDLGPVYGKQWRA 100 FL G+ + L EN+ W W+D+ G +YG QWR Sbjct: 66 FLNGENKLGELRYRTWGENDGERWTIWSDDFKRWLSSNYSSEQDWLEDAGGRIYGVQWRN 125 Query: 101 WPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGEL--DKMALAPCHAFFQFYVA-DG 157 + +G +DQ+ T++ ++K D R ++V+AWN ++ + MALAPCH FQ Y+ +G Sbjct: 126 FEGHNGCVVDQLETLVTKMKGDITDRYMLVNAWNAADIAANSMALAPCHVLFQIYITNEG 185 Query: 158 KLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTH 217 ++ Q YQRS D FLGLPFNIASY ++ ++ + + GDT +Y NHM Q + Sbjct: 186 EVDLQWYQRSVDTFLGLPFNIASYGFILEVLCKMTGYTPRYLIGVFGDTQIYQNHMKQVY 245 Query: 218 LQLSREPRPLPKLIIKRKPESIFDYRF---EDF--EIEGYDPHPGIKAPVAI 264 ++ E P I + ++ D + DF I Y I+AP+++ Sbjct: 246 ELMNNEEFHAPTFEIGVQLNTLSDLKHLTASDFIGGINNYQHAGKIEAPLSV 297 >UniRef50_B7C7C1 Putative uncharacterized protein n=1 Tax=Eubacterium biforme DSM 3989 RepID=B7C7C1_9FIRM Length = 287 Score = 154 bits (390), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 95/287 (33%), Positives = 146/287 (50%), Gaps = 35/287 (12%) Query: 4 YLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFL 63 Y L + +L+ G Q ++RTG T+ I ++ FP++TTK+ +R + E+LW Sbjct: 8 YCGLCKDILENGVQVHNRTGIDTIKIPSAHFHLDVSKEFPILTTKQLFIRQAVTEMLWIY 67 Query: 64 QGDTN-IAYLHENNVTIWDEWA-DENGD--------------------LGPVYGKQWRAW 101 Q +N + +L E NV IWD+W +E+GD +G YG + + Sbjct: 68 QAQSNDVRWLQERNVHIWDKWEINEDGDWIDENTGNVLKHFDPSFAHTIGTAYGYIVKKY 127 Query: 102 PTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSC 161 D + +LN LKND + RR ++S W ELD L C ++ V DGKL+ Sbjct: 128 --------DLMNKLLNSLKNDKEDRRRVISLWQDSELDTAVLPSCVWSSEWDVTDGKLNI 179 Query: 162 QLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLS 221 ++QRSCDV LGLPFN+ YA+L+ M+AQ L+ G W+ D H+Y N +D QL+ Sbjct: 180 WVHQRSCDVPLGLPFNVTQYAVLLMMVAQVTGLKPGTIDWSIKDAHIYVNQVDGIKEQLN 239 Query: 222 REPR----PLPKLIIKRKPESIFDYR-FEDFEIEGYDPHPGIKAPVA 263 R P P+L + +D+ +D ++ GY+ I P+A Sbjct: 240 RYETKGSLPAPELWLNPDVTDFYDFDPTKDVKLNGYEHMGKISFPLA 286 >UniRef50_A8H1B4 Thymidylate synthase n=132 Tax=root RepID=TYSY_SHEPA Length = 283 Score = 154 bits (390), Expect = 2e-36, Method: Compositional matrix adjust. Identities = 96/283 (33%), Positives = 146/283 (51%), Gaps = 19/283 (6%) Query: 1 MKQYLELMQKVLDEGT-QKNDRTGTGTLSIFGHQMRFNL-QDGFPLVTTKRCHLRSIIHE 58 MKQYL+L Q+++DEGT +N RTG L++ + +++ ++ FPL+TT++ ++ I E Sbjct: 1 MKQYLDLCQRLIDEGTWVENSRTGKRCLTVINADLVYHVDKNEFPLITTRKSFYKAAIAE 60 Query: 59 LLWFLQGDTNIAYLHENNVTIWDEWADEN------------GDLGPVYGKQWRAWPTPDG 106 LL +++G N A W+ A++N D+G VYG Q RAW PDG Sbjct: 61 LLGYIRGYDNAADFRAIGCNTWNANANDNQAWLDNPHRKGIDDMGRVYGVQGRAWSKPDG 120 Query: 107 RHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQR 166 IDQ+ +++ L D R I+S +N GE L PC F + L +QR Sbjct: 121 GCIDQLRKIVDDLSKGIDDRGEILSFYNPGEFHMGCLRPCMHTHNFSLVGDTLHLTSFQR 180 Query: 167 SCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMD-QTHLQLSREPR 225 SCDV LGL FN L+ +MAQ + G + H+Y + ++ +QL REP Sbjct: 181 SCDVPLGLNFNQVQVFTLLALMAQITGHKPGTAFHKIVNAHIYEDQLELMQEVQLKREPF 240 Query: 226 PLPKLIIKRKPESIFDYR----FEDFEIEGYDPHPGIKAPVAI 264 PKL+I +S+ D +DFE+ GY+ H I P ++ Sbjct: 241 TSPKLVINPNIKSLEDLETWVSIDDFEVTGYEHHEAISYPFSV 283 >UniRef50_Q6X183 Thymidylate synthase (Fragment) n=1 Tax=Enterobacteria phage TuIa RepID=Q6X183_9CAUD Length = 166 Score = 153 bits (386), Expect = 7e-36, Method: Compositional matrix adjust. Identities = 79/166 (47%), Positives = 108/166 (65%), Gaps = 12/166 (7%) Query: 111 QITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDV 170 Q+ ++++K P+ RR IVSAWN E+D+MAL PCH F+QF V +G L Q YQRS DV Sbjct: 1 QLVKTIDRIKALPNDRRQIVSAWNPAEIDQMALPPCHMFYQFNVRNGHLDLQWYQRSVDV 60 Query: 171 FLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKL 230 FLGLPFNIASYA L H++A+ C+L GD V++GG+TH+YSNH++Q + REP+ L L Sbjct: 61 FLGLPFNIASYAALTHIVAKMCNLIPGDLVFSGGNTHIYSNHVEQCKEVIRREPKELCSL 120 Query: 231 II------KRKPESI-FDY-----RFEDFEIEGYDPHPGIKAPVAI 264 I + P I D+ DF ++ Y+ HP IKA +A+ Sbjct: 121 EITWPSNFENWPTKIQMDWVTGTMTHTDFVLKNYESHPAIKAKMAV 166 >UniRef50_B3FJL1 Putative uncharacterized protein n=1 Tax=Pseudomonas phage 201phi2-1 RepID=B3FJL1_9CAUD Length = 457 Score = 151 bits (382), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 96/251 (38%), Positives = 122/251 (48%), Gaps = 74/251 (29%) Query: 88 GDLGPVYGKQWRA-----------WPTPDGRHIDQI-----TTVLNQ------------- 118 GDLG VYGK WR W + R D + T++ N Sbjct: 207 GDLGAVYGKTWRDIEDTRVIPKYDWVDYEARGFDFVVDVPGTSIENDRCVVTRRIDQIQD 266 Query: 119 ----LKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFY--------------------- 153 L+ +PDSRRIIV AW +D+ AL PCH+FFQF+ Sbjct: 267 IIDQLRTNPDSRRIIVCAWAPQLVDEQALPPCHSFFQFWTRELTVEERIKLLRTTKPEIY 326 Query: 154 -VADG-----------------KLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLE 195 V DG +SC LYQRS D FLG PFNI Y+LL H +A Q ++ Sbjct: 327 NVIDGTTGYFEHIADINDIPKRAISCHLYQRSVDAFLGKPFNITFYSLLTHWLANQLNMV 386 Query: 196 VGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLP--KLIIKRKPESIFDYRFEDFEIEGYD 253 +FVWTGGD H+YSNH +QT LQL+REP+ LP + + K + I + R EDFEI Y+ Sbjct: 387 ADEFVWTGGDCHIYSNHQEQTDLQLTREPKALPTIRFTPEAKGKDIREIRPEDFEILNYE 446 Query: 254 PHPGIKAPVAI 264 HP I VA+ Sbjct: 447 FHPHIAGKVAV 457 Score = 94.7 bits (234), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 45/85 (52%), Positives = 59/85 (69%), Gaps = 1/85 (1%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDG-FPLVTTKRCHLRSIIHEL 59 M+QYL+ + + + G K DRTGTGT S G Q R++L+D P++TTK+ HL SIIHEL Sbjct: 1 MQQYLDSIIDIKENGVFKGDRTGTGTQSKLGQQERYSLRDNTLPVITTKKIHLPSIIHEL 60 Query: 60 LWFLQGDTNIAYLHENNVTIWDEWA 84 +W L GDT + YL EN V IW+EW Sbjct: 61 IWMLSGDTRVDYLIENGVRIWNEWV 85 >UniRef50_A8RRN6 Thymidylate synthase n=16 Tax=Bacteria RepID=A8RRN6_9CLOT Length = 287 Score = 150 bits (380), Expect = 3e-35, Method: Compositional matrix adjust. Identities = 88/246 (35%), Positives = 128/246 (52%), Gaps = 3/246 (1%) Query: 20 DRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTI 79 D T T+ FG R++L FP++T +R +S + ELLW Q +N +H+ N I Sbjct: 44 DGTPAHTIKRFGIVNRYDLTREFPVITLRRTAFKSAVDELLWIWQKKSN--NIHDLNSHI 101 Query: 80 WDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELD 139 WD WADENG +G YG Q DQ+ +L LK++P SRRI+ + +N +L Sbjct: 102 WDSWADENGSIGKAYGYQLGVKHHYKEGDFDQVDRILYDLKHNPLSRRIMSNIYNHHDLC 161 Query: 140 KMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDF 199 +M L PC F V+ L+ L QRS D+ +N+ YA+L+HM+AQ L+ G+ Sbjct: 162 EMNLYPCAYSMTFNVSGNTLNGILNQRSQDMLTANSWNVCQYAVLLHMLAQVSGLKPGEL 221 Query: 200 VWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHP-GI 258 V D H+Y H+ L REP P P L + ++ + + + F +E Y H Sbjct: 222 VHVIADAHIYDRHIPMVEELLKREPYPGPTLSMDTSIQNFYQFTTDSFRLEHYQYHTFSG 281 Query: 259 KAPVAI 264 K PVAI Sbjct: 282 KIPVAI 287 >UniRef50_B6FSV1 Putative uncharacterized protein n=1 Tax=Clostridium nexile DSM 1787 RepID=B6FSV1_9CLOT Length = 282 Score = 147 bits (372), Expect = 2e-34, Method: Compositional matrix adjust. Identities = 88/279 (31%), Positives = 142/279 (50%), Gaps = 18/279 (6%) Query: 2 KQYLELMQKVLDEGTQKN---------DRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHL 52 K ++++ + ++D G D + TL F R++L FP +T +R + Sbjct: 6 KVFIDMCRDIIDNGVSTEGEKVRPKWEDGSFAYTLKKFCVVNRYDLSKEFPALTLRRTGI 65 Query: 53 RSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQI 112 +S + ELLW Q +N +H+ IWD WADE+G +G YG Q +DQ+ Sbjct: 66 KSCVDELLWIWQRKSN--NVHDLKPHIWDSWADEDGSIGKAYGYQMSVKHQYKEGMMDQV 123 Query: 113 TTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGK------LSCQLYQR 166 V+ LKN+P SRRI+ + + +L +M L PC F V L+ L QR Sbjct: 124 DRVIYDLKNNPYSRRIMTNIYVHQDLHEMNLYPCAYSMTFNVTKKNDSDKLVLNGILNQR 183 Query: 167 SCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRP 226 S DV +N+ YA+L+HM+AQ CD++VG+FV D H+Y H+ +SREP P Sbjct: 184 SQDVLAANNWNVCQYAVLMHMLAQVCDMQVGEFVHVIADAHIYDRHIPLVEELISREPLP 243 Query: 227 LPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIK-APVAI 264 P + + ++ +++ +D ++ Y+ IK P+A+ Sbjct: 244 APTFWLNPEVKNFYEFTPDDVRLDNYETGSQIKNIPIAV 282 >UniRef50_C3IV33 Thymidylate synthase n=2 Tax=Bacillus thuringiensis RepID=C3IV33_BACTU Length = 306 Score = 142 bits (357), Expect = 1e-32, Method: Compositional matrix adjust. Identities = 82/262 (31%), Positives = 129/262 (49%), Gaps = 22/262 (8%) Query: 20 DRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTI 79 D + T IFG R++L FP TT+ L++I E+ W + +N +++ I Sbjct: 50 DGSPIATKRIFGVVNRYDLSKEFPAPTTRPLPLKTIFDEVDWIYRKRSN--NVNDMRAKI 107 Query: 80 WDEWA-----------------DENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKND 122 W++WA ++ G +G YG Q P + +Q+ VL +LK D Sbjct: 108 WNQWAFKKTRLRFSKTFPFVRLEKKGSIGEAYGYQV---AKPIFGYDNQMDYVLGELKRD 164 Query: 123 PDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYA 182 P +RR ++ WNV + +M L PC QF+ K + L QRS D FN+ YA Sbjct: 165 PFTRRAVIEMWNVDDTGRMNLPPCAHHLQFWSDGKKTNLILKQRSQDFVTANAFNVCEYA 224 Query: 183 LLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDY 242 +L+HM+A+ EVG+ + GD H+Y+ H++ + REP P L I + + + Sbjct: 225 ILLHMVARHIGQEVGELLHIIGDCHIYNKHLELAEELVKREPYAAPTLWINPEKTDFYSF 284 Query: 243 RFEDFEIEGYDPHPGIKAPVAI 264 +DF +E YD HP +K VA+ Sbjct: 285 TADDFRLENYDKHPQMKIEVAV 306 >UniRef50_B8QTX3 Putative thymidylate synthase n=1 Tax=Erwinia phage phiEa21-4 RepID=B8QTX3_9CAUD Length = 311 Score = 141 bits (355), Expect = 3e-32, Method: Compositional matrix adjust. Identities = 88/249 (35%), Positives = 122/249 (48%), Gaps = 38/249 (15%) Query: 2 KQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLW 61 +QY +L G ++ R+G F +R +++ FPL+T K + + ELLW Sbjct: 6 QQYKAFTANILSNGELRHSRSGNTISVPFPEDLRIDVRKEFPLLTCKSVPMSLVAGELLW 65 Query: 62 FLQGDTNIAYLH-------ENNVTIWD---------------------------EWADEN 87 FL G T++ L E TIW D Sbjct: 66 FLAGKTDLHSLRMYQFGSDEGQNTIWTADYERYSKAVKSLIRKVQTGESQEKTLRKIDAQ 125 Query: 88 GDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWN-VGELDKM-ALAP 145 DLG +YG QWR + + D DQIT ++ +K +P SR IVSAWN V + + AL P Sbjct: 126 EDLGMIYGSQWREFESCD-TTCDQITRLIEGIKENPASRYHIVSAWNPVAVANNLGALPP 184 Query: 146 CHAFFQFYVADGK-LSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGG 204 CH FFQ Y ++G + + YQRS D FLGLPFNIASYALL+ ++AQ + + G Sbjct: 185 CHMFFQVYASEGGYMDLRWYQRSVDTFLGLPFNIASYALLLRILAQMTGYTARYVIGSFG 244 Query: 205 DTHLYSNHM 213 D H+Y NH+ Sbjct: 245 DAHIYENHV 253 >UniRef50_A8E2Q5 Putative thymidylate synthase n=1 Tax=Enterococcus phage phiEF24C RepID=A8E2Q5_BPPHE Length = 315 Score = 139 bits (351), Expect = 7e-32, Method: Compositional matrix adjust. Identities = 92/294 (31%), Positives = 138/294 (46%), Gaps = 41/294 (13%) Query: 12 LDEGTQKNDRTGTGTLSIFGHQMRFNLQD--GFPLVTTKRCHLRSIIHELLWFLQGDTN- 68 L EGT+ GT + F + F + G PL+ +K ++ + EL W Q +N Sbjct: 22 LPEGTRAVYADGTPATTKFIEGVNFTITPDMGAPLLRSKHVGIKWALTELQWIWQEMSNE 81 Query: 69 IAYLHENNVTIWDEWADENGDLGPVYG----KQWRAWPTPDGR----------------- 107 +++L E VTIWDEW E+G +G YG + R P G Sbjct: 82 VSWLKERGVTIWDEWEQEDGTIGKAYGYALFNKERFIPVYSGDVELAKNRKAGSLIPKVV 141 Query: 108 ---------------HIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQF 152 ++Q+ V+ QLK+ P+SRRI+ + WNV +L M+L PC + Sbjct: 142 PKKGGWIAGTHQPYLKLNQVEAVIEQLKSTPNSRRIMTTLWNVEDLYDMSLEPCVWTTHW 201 Query: 153 YVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNH 212 V +GKL+ + RS DV LGLPFNI Y L +MA LE+G+ WT + H+Y H Sbjct: 202 TVVEGKLNLHVKARSSDVCLGLPFNIIQYHALQLVMANTVGLELGNLYWTSDNAHIYERH 261 Query: 213 MDQTHLQLSRE-PRPLPKLIIK-RKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 ++ Q++ P +PKL++ +K + FD D + Y + VAI Sbjct: 262 LELVEKQVNEPIPEEVPKLVLPWKKGTNFFDSPLSDISVINYKHNGKFNYEVAI 315 >UniRef50_Q8RGP6 Thymidylate synthase n=10 Tax=Fusobacterium RepID=TYSY_FUSNN Length = 275 Score = 139 bits (350), Expect = 9e-32, Method: Compositional matrix adjust. Identities = 90/252 (35%), Positives = 134/252 (53%), Gaps = 8/252 (3%) Query: 16 TQKNDRTGTGTLSIFGHQMRF-NLQDGFPLVTTKRCHLRSIIHEL--LWFLQGDTNIAYL 72 T+ D T S G+Q R N D L+T++ ++ I EL +W LQ + N+ L Sbjct: 29 TKYADGTAAHYKSYIGYQFRLDNSDDEAHLITSRFAPSKAPIRELYWIWILQSN-NVDVL 87 Query: 73 HENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSA 132 +E WDEW ++G +G YG Q A T + Q+ V+N+LK +P+SRRI+ Sbjct: 88 NELGCKFWDEWKMQDGTIGKAYGYQ-IAQETFGQK--SQLHYVINELKKNPNSRRIMTEI 144 Query: 133 WNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQC 192 W EL +MAL PC Q+ V KL ++ QRSCDV LGL N+ Y++L ++A +C Sbjct: 145 WIPNELSEMALTPCVHLTQWSVIGNKLYLEVRQRSCDVALGLVANVFQYSVLHKLVALEC 204 Query: 193 DLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGY 252 LE + +W + H+Y H D+ Q++RE K+ I +SIFD++ +D EI Y Sbjct: 205 GLEPAEIIWNIHNMHIYDRHYDKLIEQVNRETFEPAKIKI-NNFKSIFDFKPDDIEIIDY 263 Query: 253 DPHPGIKAPVAI 264 + VAI Sbjct: 264 KYGEKVSYEVAI 275 >UniRef50_C4Z7Z1 Thymidylate synthase n=19 Tax=Bacteria RepID=C4Z7Z1_EUBR3 Length = 282 Score = 139 bits (350), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 87/279 (31%), Positives = 135/279 (48%), Gaps = 18/279 (6%) Query: 2 KQYLELMQKVLDEGTQKN---------DRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHL 52 K ++ + Q +L+ GT D T T+ FG R++L FP +T ++ ++ Sbjct: 6 KVFVAMCQDILENGTSTEGELVRPHWEDGTSAYTIKKFGVVNRYDLSKEFPAITLRKTYI 65 Query: 53 RSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQI 112 +S ELLW Q +N +H+ +WDEWADE+G +G YG Q +DQ+ Sbjct: 66 KSATDELLWIWQKKSN--NIHDLKSHVWDEWADEDGSIGKAYGYQLGVKHQYKEGMMDQV 123 Query: 113 TTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGK------LSCQLYQR 166 V+ LK+ P SRRI+ + + +L +M L PC F V K L+ L QR Sbjct: 124 DRVIYDLKHTPFSRRILTNIYVHQDLHEMNLYPCAYSMTFNVTQKKGDDRLTLNGILNQR 183 Query: 167 SCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRP 226 S DV +N+ YA+L+HM+AQ CD+ VG+ V D H+Y H+ + R Sbjct: 184 SQDVLAANNWNVCQYAVLMHMLAQVCDMRVGELVHVIADAHIYDRHVPIVKELIERPQYD 243 Query: 227 LPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIK-APVAI 264 PK + + + + +D +I Y IK P+A+ Sbjct: 244 APKFWLNPDIKDFYQFTTDDIKITDYVTGEQIKDIPIAV 282 >UniRef50_B9CJY5 Thymidylate synthase n=10 Tax=Bacteria RepID=B9CJY5_9ACTN Length = 282 Score = 133 bits (334), Expect = 7e-30, Method: Compositional matrix adjust. Identities = 82/253 (32%), Positives = 128/253 (50%), Gaps = 11/253 (4%) Query: 20 DRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTI 79 D T T+ FG R++L++ FP +T +R L+S + E+LW Q +N +H+ N I Sbjct: 33 DGTPAYTIKKFGVCNRYDLREEFPALTLRRTALKSAMDEVLWIYQKKSN--NVHDLNSHI 90 Query: 80 WDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELD 139 WD WADE+G +G YG Q DQ+ VL L+N+P SRRI+ + + +L Sbjct: 91 WDAWADESGSIGKAYGYQVGQKSHYAEGDFDQMDRVLYDLQNNPFSRRIMTNLYTFADLS 150 Query: 140 KMALAPCHAFFQFYV-------ADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQC 192 +M L PC AF Y A L+ L QRS D+ +N+ YA+L+ M+AQ Sbjct: 151 EMNLYPC-AFNAIYNVTQNPGDAKPTLNLLLVQRSQDILAANNWNVCQYAILLMMVAQVS 209 Query: 193 DLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGY 252 ++ G+ V D H+Y H+D +SR P + + + + +D +E Y Sbjct: 210 GMQAGELVHMISDAHIYDRHVDIVRELISRPIFAAPHVSLNPDVTDFYAFTTDDLIVENY 269 Query: 253 DPHPGIK-APVAI 264 + P +K P+A+ Sbjct: 270 EHGPQVKNIPIAV 282 >UniRef50_C6JM98 Thymidylate synthase n=6 Tax=Fusobacterium RepID=C6JM98_FUSVA Length = 276 Score = 131 bits (330), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 87/270 (32%), Positives = 136/270 (50%), Gaps = 11/270 (4%) Query: 2 KQYLELMQK--VLDEG---TQKNDRTGTGTLSIFGHQMRF-NLQDGFPLVTTKRCHLRSI 55 K+ +E++ K + EG T+ D T S G+Q R N D L+TT+ ++ Sbjct: 11 KEIVEIIDKNGIWSEGNVRTKYADGTPAHYKSYIGYQFRLDNSTDEAHLITTRFAPNKAP 70 Query: 56 IHELLW-FLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITT 114 I EL W ++ ++ L++ WDEW +G +G YG Q + Q+ Sbjct: 71 IRELYWIWIMQSNDVDELNKLKCKFWDEWKMNDGTIGKAYGYQI---AKQTFGYKSQLDY 127 Query: 115 VLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGL 174 V+ +LK +P+SRRI+ W +LDKMAL PC Q+ V KL ++ QRSCDV LGL Sbjct: 128 VIGELKKNPNSRRIMTEIWVPEDLDKMALTPCVHLTQWSVIGNKLYLEVRQRSCDVALGL 187 Query: 175 PFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKR 234 N+ Y++L ++A +C+LE + +W + H+Y HM Q+ R P + Sbjct: 188 VANVFQYSILHKLVAMECNLEPAEIIWNIHNVHIYDRHMPDLLEQIKR-PSIDGATVKIE 246 Query: 235 KPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 +SI+D++ +D +E Y I VAI Sbjct: 247 NFKSIYDFKPDDVVVENYQYGEKISYEVAI 276 >UniRef50_A2SMX7 Thymidylate synthase n=1 Tax=Methylibium petroleiphilum PM1 RepID=A2SMX7_METPP Length = 316 Score = 128 bits (321), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 88/281 (31%), Positives = 132/281 (46%), Gaps = 47/281 (16%) Query: 1 MKQYLELMQKVLDEGT-QKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHEL 59 M+Q+ +++Q +LD G+ Q N RTG L + G+ +RF++ DGFP +TTK+ + EL Sbjct: 1 MQQFHDMLQHILDHGSRQLNARTGEEVLFVPGYTLRFDMADGFPAITTKQLFFKMAKGEL 60 Query: 60 LWFLQGDTNIAYLHENNVTIWDEWA---------------DENGDLGPVYGKQWRAW--- 101 F +G T+ A E T+W++ A D+ G G + WR W Sbjct: 61 FGFFRGFTSAAQFREIGCTVWNDNANKTKAWLANPYRQGEDDLGRFGYLQWTDWRDWREA 120 Query: 102 PTPDG------------------------RHIDQITTVLNQLKNDPDSRRIIVSAWNVGE 137 TP R I+Q+ T L+ + +P R II+S WN E Sbjct: 121 TTPAQRDEMLAQGYEVRAHDAERGVWILRRSINQLETSLHAVMTNPSDRGIILSGWNPAE 180 Query: 138 LDKMALAPCHAFF--QFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLE 195 +D+ AL CH + Q VA G L L+QRS D L +N+A A+ + +MA+ L+ Sbjct: 181 IDQGALRSCHVSYMLQVDVATGTLHLTLWQRSFDA--PLAYNVAIGAMYLEIMARLAGLK 238 Query: 196 VGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKP 236 G F D H+Y+ H+ L+RE P P L + P Sbjct: 239 AGTFTHFISDAHIYAKHIPGVKEMLAREHFPQPTLDLGNIP 279 >UniRef50_Q8MVZ9 Bifunctional dihydrofolate reductase-thymidylate synthase (Fragment) n=1 Tax=Cercomonas longicauda RepID=Q8MVZ9_9EUKA Length = 314 Score = 116 bits (291), Expect = 6e-25, Method: Compositional matrix adjust. Identities = 63/167 (37%), Positives = 96/167 (57%), Gaps = 22/167 (13%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDG-FPLVTTKRCHLRSIIHELLW 61 +Y++L++++ D+G + DRTG G +FG+ M+F+L++G PL+T ++ + ++ ELLW Sbjct: 148 EYIDLIRRIRDQGEIRTDRTGVGIKCVFGNMMKFSLENGQIPLLTIRKIFWKGVVEELLW 207 Query: 62 FLQGDTNIAYLHENNVTIWDEWAD------------ENGDLGPVYGKQWR--------AW 101 L+G T+ L E V IW E GDLGP+YG QWR A Sbjct: 208 MLRGKTHSRDLEEKGVNIWRANGSREALDRLGMVDREVGDLGPIYGWQWRHSGAXYTTAH 267 Query: 102 PTPDGRHIDQITTVLNQLKNDP-DSRRIIVSAWNVGELDKMALAPCH 147 G +DQI V++QL+N P +RRI+ +WN +L +MAL PCH Sbjct: 268 TDYSGFGVDQIKDVISQLQNQPQKNRRILFCSWNPKDLKQMALPPCH 314 >UniRef50_Q8MVZ5 Bifunctional dihydrofolate reductase-thymidylate synthase (Fragment) n=1 Tax=Tetrahymena sp. RepID=Q8MVZ5_9HYMN Length = 311 Score = 111 bits (277), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 57/109 (52%), Positives = 68/109 (62%), Gaps = 13/109 (11%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDG-FPLVTTKRCHLRSIIHELLW 61 QYL+L+Q+V+ G + DRTGTGTLSIFG MRF+L G FPL+TTK+ LR I EL W Sbjct: 198 QYLDLVQRVVSTGVSRGDRTGTGTLSIFGAMMRFDLSSGAFPLLTTKKTFLRGIAEELFW 257 Query: 62 FLQGDTNIAYLHENNVTIWDEWADE------------NGDLGPVYGKQW 98 FL+GDT+ L +V IWD A GDLGPVYG QW Sbjct: 258 FLKGDTSQTRLAAKDVHIWDANATRAFLDARGLPDRPEGDLGPVYGCQW 306 >UniRef50_C7HUX5 Thymidylate synthase n=2 Tax=Anaerococcus RepID=C7HUX5_9FIRM Length = 287 Score = 111 bits (277), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 75/273 (27%), Positives = 139/273 (50%), Gaps = 21/273 (7%) Query: 2 KQYLELMQKVLDEGTQKNDRT---------GTGTLSIFGHQMRFNLQDG-FPLVTTKRCH 51 ++Y+++ +++L++G + + G + + Q + G PL++ ++ Sbjct: 5 EKYIKIAKEILEKGYDEEELNKEVRPVWDDGESAYTKYLPQQVVRYEKGELPLISLRKIA 64 Query: 52 LRSIIHELLWFLQGDTN-IAYLHEN-NVTIWDEWADENGDLGPVYGKQW-RAWPTPD-GR 107 +S I E+LW Q +N + L E V WD W +E+G+LG YG Q + + +P+ G+ Sbjct: 65 WKSAIKEILWIYQDRSNDVNLLKEKYKVNYWDSWKNEDGNLGTAYGYQINKKFKSPETGQ 124 Query: 108 HIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGK-LSCQLYQR 166 +QI +++Q+KN+P +RR+I++ +V ++ M L PC AF + G+ L+ L QR Sbjct: 125 MTNQIERLIDQIKNNPLNRRLIMNLIDVDDMADMTLIPC-AFLTMWTVSGEYLNLTLVQR 183 Query: 167 SCDVFLGLP---FNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTH--LQLS 221 S D N Y +L+ M+AQ + GDFV + H+Y H+ L++ Sbjct: 184 SGDFLAAAAPGGINAFQYYVLLRMVAQVTGYKAGDFVHFIQNYHIYKKHIPSVKKILEIK 243 Query: 222 REPRPLPKLIIKRKPESIFDYRFEDFEIEGYDP 254 + + P+L I + D+ +DF++ Y P Sbjct: 244 VDEKSKPRLEINPDIKEFKDFTIDDFKLIDYYP 276 >UniRef50_Q8MVZ8 Bifunctional dihydrofolate reductase-thymidylate synthase (Fragment) n=1 Tax=Chlamydaster sterni RepID=Q8MVZ8_9EUKA Length = 260 Score = 106 bits (265), Expect = 6e-22, Method: Compositional matrix adjust. Identities = 56/111 (50%), Positives = 73/111 (65%), Gaps = 13/111 (11%) Query: 2 KQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQ-DGFPLVTTKRCHLRSIIHELL 60 KQYL+L+ +++ GTQ+ DRTGTGTLSIFG QMRF+ + D PL+TTK+ R + E+L Sbjct: 146 KQYLDLVDRIITSGTQRGDRTGTGTLSIFGTQMRFSPRDDTLPLLTTKKVFWRGVAEEML 205 Query: 61 WFLQGDTNIAYLHENNVTIWDEWA-----DEN-------GDLGPVYGKQWR 99 WF++G T+ L + IWD+ A DEN GDLGPVYG QWR Sbjct: 206 WFMKGCTDARVLSAKKIHIWDDNASRKFLDENGLSHREEGDLGPVYGFQWR 256 >UniRef50_Q1ZMM6 Thymidylate synthase n=3 Tax=Gammaproteobacteria RepID=Q1ZMM6_PHOAS Length = 187 Score = 105 bits (263), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 64/186 (34%), Positives = 96/186 (51%), Gaps = 14/186 (7%) Query: 1 MKQYLELMQKVLDEGTQ-KNDRTGTGTLSIFGHQMRFNLQDG-FPLVTTKRCHLRSIIHE 58 MKQYL L Q+++D+G +N+RTG L++ + +++ + FPL+TT++ ++ I E Sbjct: 1 MKQYLALCQRIVDDGVWIENERTGKRCLTVINADLTYDVANNQFPLITTRKSFWKAAIAE 60 Query: 59 LLWFLQGDTNIAYLHENNVTIWDEWADEN------------GDLGPVYGKQWRAWPTPDG 106 LL +L+G N A W+ A++N D+G VYG Q R W DG Sbjct: 61 LLGYLRGYDNAAQFRAIGCNTWNANANDNQAWLNNPHRKGEDDMGRVYGVQGRRWQKSDG 120 Query: 107 RHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQR 166 IDQ+ +++ L D R I++ +N GE D L PC F + L YQR Sbjct: 121 TPIDQLKKIVDDLTKGIDDRGEILTFYNPGEFDMGCLRPCMHTHTFSLLGDTLYLTSYQR 180 Query: 167 SCDVFL 172 SCDV L Sbjct: 181 SCDVPL 186 >UniRef50_Q8MW00 Bifunctional dihydrofolate reductase-thymidylate synthase (Fragment) n=1 Tax=Amastigomonas debruynei RepID=Q8MW00_9EUKA Length = 259 Score = 105 bits (263), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 52/107 (48%), Positives = 69/107 (64%), Gaps = 12/107 (11%) Query: 4 YLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFL 63 YL+L+++VL +G +++DRTG GT S+FG ++ F+L DGFPL+TTKR R + ELLWF+ Sbjct: 148 YLDLIRRVLADGFERDDRTGVGTFSLFGEKLEFDLGDGFPLLTTKRVFWRGVAEELLWFV 207 Query: 64 QGDTNIAYLHENNVTIWD-----EWAD-------ENGDLGPVYGKQW 98 G TN L + IWD E+ D E GDLGPVYG QW Sbjct: 208 SGSTNANELAAKGIRIWDGNSSREYLDSIGLTEREVGDLGPVYGFQW 254 >UniRef50_Q03LN3 Thymidylate synthase n=75 Tax=Firmicutes RepID=TYSY_STRTD Length = 286 Score = 102 bits (255), Expect = 9e-21, Method: Compositional matrix adjust. Identities = 87/287 (30%), Positives = 135/287 (47%), Gaps = 34/287 (11%) Query: 4 YLELMQKVLDEGT-------QKNDRTGTGTLSIFGHQMRFNLQDG-FPLVTTKRCHLRSI 55 + E + K+++EG + D T + I G ++L G FP+ T + ++S Sbjct: 8 FKENITKIMEEGVWSEQARPKYKDGTTANSKYITGSFAEYDLSKGEFPITTLRPIAIKSA 67 Query: 56 IHELLWFLQGDTNIAYLHEN--NVTIWDEWADE-----NGD---LGPVYGKQWRAWPTPD 105 I E+ W Q TN + E+ NV W++W E NGD +G YG + Sbjct: 68 IKEVFWIYQDQTNSLDVLEDKYNVHYWNDWEVEGVPANNGDKRSIGQRYGAVVK------ 121 Query: 106 GRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMA-LAPCHAFFQFYV----ADGKLS 160 +H D I +L QL+ +P +RR ++S W+ ++ A L PC F V D L Sbjct: 122 -KH-DIINRLLAQLEANPWNRRNVISLWDYEAFEETAGLQPCAFQTMFDVRRVGEDVYLD 179 Query: 161 CQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQL 220 L QRS D+ + N Y L M+A+ +VG F + + H+Y N +Q L Sbjct: 180 ATLTQRSNDMLVAHHINAMQYVALQMMIAKHFGWKVGKFFYFINNLHIYDNQFEQAEELL 239 Query: 221 SREPRPL-PKLIIKRKPES-IFDYRFEDFEIEGYDP-HPGIKAPVAI 264 R+P P+L++ E+ FD + EDFE+ YDP P +K +AI Sbjct: 240 KRQPSDCQPRLVLNVPDETNFFDIKPEDFELVDYDPVKPQLKFDLAI 286 >UniRef50_C0ELR2 Putative uncharacterized protein n=1 Tax=Neisseria flavescens NRL30031/H210 RepID=C0ELR2_NEIFL Length = 309 Score = 102 bits (255), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 67/237 (28%), Positives = 109/237 (45%), Gaps = 18/237 (7%) Query: 2 KQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLW 61 +QY++L++ +LD +N+RTGT +I Q D FP +T +R + +S + E+L Sbjct: 21 QQYVQLLKDLLDAPLVRNERTGTACHTIINPQSFTYTADDFPALTIRRSYWKSAVAEMLG 80 Query: 62 FLQGDTNIAYLHENNVTIWDEWADEN------------GDLGPVYGKQWRAWPTPDGRHI 109 +++G T+ E WD A++N D+G VYG ++ Sbjct: 81 YIRGYTSAKDFRELGTKTWDANANQNPAWLANPHRAGVDDMGLVYGAVGNSFTGL----- 135 Query: 110 DQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCD 169 T ++ + D+R +I S WN DK L PC QF + +G L QRSCD Sbjct: 136 -SFTDIMRAIHARQDNRGLIWSFWNPDVFDKGCLRPCMYSHQFSIVNGTLYLTSTQRSCD 194 Query: 170 VFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRP 226 V LGL FN+ L++++ L+ G + H+Y N +D ++ P Sbjct: 195 VPLGLTFNMIQCWFLLYLVCTLTGLKFGHARHNIVNAHIYENQVDAVREMIANPLLP 251 >UniRef50_UPI00016AD9CB thymidylate synthase n=1 Tax=Burkholderia thailandensis MSMB43 RepID=UPI00016AD9CB Length = 193 Score = 100 bits (249), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 62/171 (36%), Positives = 88/171 (51%), Gaps = 13/171 (7%) Query: 107 RHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFY--VADGKLSCQLY 164 + IDQ+ L+ + DP SRRI+ WN LD++AL CH +QF V ++S LY Sbjct: 23 KAIDQLRDCLDTIVRDPSSRRILFHGWNPAVLDEIALPACHLLYQFLPNVERREISLCLY 82 Query: 165 QRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREP 224 RS DV LG PFN+A A L+ ++ + F + GD H+Y N +D QL REP Sbjct: 83 IRSNDVGLGTPFNLAEGAALLTLVGRLTGYTPRWFTYFIGDAHIYENQLDMLKQQLEREP 142 Query: 225 RPLPKL-IIKRKPESIFDYRFE----------DFEIEGYDPHPGIKAPVAI 264 P+L I +R P+ +E DF + GY H + AP+A+ Sbjct: 143 FESPRLEIAERVPDYAKTGEYEPQWLERIEPSDFALVGYRHHEPLTAPMAV 193 >UniRef50_Q8MVZ6 Bifunctional dihydrofolate reductase-thymidylate synthase (Fragment) n=1 Tax=Diplonema ambulator RepID=Q8MVZ6_9EUGL Length = 255 Score = 93.6 bits (231), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 50/110 (45%), Positives = 66/110 (60%), Gaps = 13/110 (11%) Query: 2 KQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDG-FPLVTTKRCHLRSIIHELL 60 +QYL+L+ ++ G K DRTG GT+S FG QMRF+L+DG PL+TTKR + + EL Sbjct: 141 QQYLDLVDDIIKNGFTKGDRTGVGTISKFGAQMRFSLRDGVIPLLTTKRVFWKGVAEELF 200 Query: 61 WFLQGDTNIAYLHENNVTIWD-----EWADENG-------DLGPVYGKQW 98 WF++G TN L + V IWD + D G DLGP+YG QW Sbjct: 201 WFIKGCTNGKDLKDKGVHIWDGNGTRAFLDSRGLPDRAEDDLGPIYGLQW 250 >UniRef50_B9PCT2 Predicted protein (Fragment) n=2 Tax=root RepID=B9PCT2_POPTR Length = 57 Score = 89.7 bits (221), Expect = 8e-17, Method: Composition-based stats. Identities = 38/57 (66%), Positives = 50/57 (87%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIH 57 MKQYL+ M+ V + GT+K+DRTGTGT S+FG+QMRF+L +GFP+VTTK+ HL+SIIH Sbjct: 1 MKQYLDFMRHVYEHGTEKSDRTGTGTRSVFGYQMRFDLNEGFPVVTTKKLHLKSIIH 57 >UniRef50_B2IB94 Thymidylate synthase n=2 Tax=Rhizobiales RepID=B2IB94_BEII9 Length = 342 Score = 83.2 bits (204), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 57/204 (27%), Positives = 101/204 (49%), Gaps = 11/204 (5%) Query: 17 QKNDRTGTG----TLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYL 72 +++ RT G T+ + G +R + R S I ELLW+L G +A++ Sbjct: 20 KEHGRTNAGSRGNTVELLGVALRILKPRARISRSENRGKPFSAIGELLWYLSGLDTLAFI 79 Query: 73 HENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSA 132 E V+ + + A G + YG + RA DG IDQ ++ L+ P+SRR ++ Sbjct: 80 -EPYVSAYRDDA-VAGVIQGAYGPRLRA--MRDG--IDQFASIETLLRQKPNSRRAVIQL 133 Query: 133 WNVGEL-DKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQ 191 +N ++ + PC QF++ DG L + RS D + GLP ++ + ++ MMA++ Sbjct: 134 FNAEDIATEHKEIPCTTTLQFHLRDGLLHMSVTMRSNDAYWGLPHDVFCFTMIQEMMARR 193 Query: 192 CDLEVGDFVWTGGDTHLYSNHMDQ 215 +E+G++ G H+Y H++ Sbjct: 194 LGVELGEYYHYVGSMHVYEKHLNH 217 >UniRef50_A7TUR1 Putative thymidylate synthase n=3 Tax=Streptomyces RepID=A7TUR1_STRLI Length = 308 Score = 77.0 bits (188), Expect = 6e-13, Method: Compositional matrix adjust. Identities = 59/211 (27%), Positives = 100/211 (47%), Gaps = 20/211 (9%) Query: 56 IHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTV 115 + E +W L G ++ ++ + N + ++AD+ LG YG + R W G +DQ+ V Sbjct: 57 VAETVWHLSG-SDAPWIFDYNYRL-RQFADDGVLLG-AYGPRMRNW----GGKVDQLARV 109 Query: 116 LNQLKNDPDSRRIIVSAWN-----VGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDV 170 + L+ D DSRR ++ ++ G D PC F+F++ G+L R DV Sbjct: 110 VEILQADSDSRRALIQLYDPAQDAAGHKD----VPCTLGFRFHLRAGRLHMATMMRGQDV 165 Query: 171 FLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRP-LPK 229 ++G+P+++ Y +L ++A D E+G+F G H+Y H++Q S +P Sbjct: 166 WIGMPYDVFFYTVLHELVAGWLDAELGEFHLHIGSLHIYDEHIEQADALTSLSASEIMPD 225 Query: 230 LIIKRKPESIFDYRFEDFEIEGYDPHPGIKA 260 L R P + F + E HPG A Sbjct: 226 L---RTPWTGFSGLLDQVEARDVTGHPGWDA 253 >UniRef50_Q13T72 Thymidylate synthase n=4 Tax=Burkholderiaceae RepID=Q13T72_BURXL Length = 354 Score = 75.1 bits (183), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 44/172 (25%), Positives = 89/172 (51%), Gaps = 10/172 (5%) Query: 46 TTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPD 105 + K+ L S + E LW+L G + ++ + ++ + +++D+ + YG R + Sbjct: 55 SEKKNTLFSCLGEFLWYLAGSDKLDFI-QYYISRYKDFSDDGKTVFGAYGP--RLFGPTS 111 Query: 106 GRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALA-----PCHAFFQFYVADGKLS 160 G DQ+ V+ L+ + SRR ++ ++ +L + PC QF++ + +L+ Sbjct: 112 G--TDQVQNVIQTLRANQHSRRAVIQLFHGDDLAANLVKRREDLPCTCTLQFFIRNYQLN 169 Query: 161 CQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNH 212 + RS D F+GLP +I ++ +L ++A+ +EVG + G HLY+N+ Sbjct: 170 AMVTMRSNDAFMGLPHDIFAFTMLQELIARSLGVEVGQYKHAVGSLHLYANN 221 >UniRef50_B2HI72 Thymidylate synthase, ThyA_1 n=1 Tax=Mycobacterium marinum M RepID=B2HI72_MYCMM Length = 316 Score = 73.9 bits (180), Expect = 5e-12, Method: Compositional matrix adjust. Identities = 50/183 (27%), Positives = 84/183 (45%), Gaps = 30/183 (16%) Query: 45 VTTKRCHL---------RSIIHELLWFLQGDTNIAYL------HENNVTIWDEWADENGD 89 +T RC L R+ I +L W+L G TN + H N + + +G Sbjct: 45 LTEPRCRLSRTEARRLSRTGIAQLAWYLSGTTNPEMILHWVPNHRNEL-------EADGT 97 Query: 90 LGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELD---KMALAPC 146 + YG R + T D Q TVL LK SRR ++ ++ +L + PC Sbjct: 98 IHGAYGP--RMFGTGDN---AQFCTVLELLKTSSSSRRAVIQLFDATDLTGPGRYKDVPC 152 Query: 147 HAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDT 206 QF+V D +L + RS D ++GLP ++ ++ +L +MA + + +G ++ + G Sbjct: 153 TNTLQFFVRDSRLHLMVTMRSNDAYIGLPLDVFAFTMLQELMAGELGIGIGRYIHSVGSL 212 Query: 207 HLY 209 H+Y Sbjct: 213 HIY 215 >UniRef50_B5S769 Putative thymidylate synthase protein n=1 Tax=Ralstonia solanacearum RepID=B5S769_RALSO Length = 294 Score = 73.6 bits (179), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 67/227 (29%), Positives = 102/227 (44%), Gaps = 23/227 (10%) Query: 17 QKNDRTGTGTLSIFGHQMRFNLQD---GFPLVTTKRCHLRSIIHELLWFLQGDT---NIA 70 Q+ G TL + + F + D + + +R + I EL W L+G + IA Sbjct: 9 QRTAPRGVATLELL--PVAFTINDPRRRYVSLPPRRWSIVYAIGELCWHLRGSSLVDEIA 66 Query: 71 YLHENNVTIWDEWADENG-DLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRII 129 Y TI + G + G K R P+ Q + V+NQL+ D DSRR + Sbjct: 67 YYASRWRTIAGNATEVTGSNYGAKIFKGHRGAPS-------QWSRVINQLRIDRDSRRAV 119 Query: 130 VSAWNVGE---LDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVH 186 + GE D +A C QF + DGKL RS D LGLP+++ +++L Sbjct: 120 LYFSGTGEDTSSDSKDIA-CAVSLQFLIRDGKLDAIANMRSNDAMLGLPYDVFLFSMLQE 178 Query: 187 MMAQQCDLEVGDFVWTGGDTHLY-SNHMDQTHLQLSR--EPRPLPKL 230 M A ++VG + G HLY S+ + + SR E RP+P++ Sbjct: 179 MAANSLGVDVGKYNHVAGSLHLYESDLLLAKDIISSRASEIRPMPRM 225 >UniRef50_Q03W75 Thymidylate synthase n=13 Tax=Bacteria RepID=Q03W75_LEUMM Length = 335 Score = 71.6 bits (174), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 43/165 (26%), Positives = 83/165 (50%), Gaps = 5/165 (3%) Query: 47 TKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDG 106 T++ ++ E LW+L G+ +++Y+ N + D D G YGK+ + + Sbjct: 55 TRKTNIIFNFAEALWYLTGNNSLSYISYYNKRMPDYSMDGQTLTGTAYGKKLFHFGEQN- 113 Query: 107 RHIDQITTVLNQLKNDPDSRRIIVSAWNVGEL--DKMALAPCHAFFQFYVADGKLSCQLY 164 ++Q V +L ND DS+R ++ ++ EL ++ C QF + + +L+ Y Sbjct: 114 --LNQWQNVKQELLNDADSKRAVIQIFDAHELTINQNLDVSCTLGLQFLIRNNQLNMVAY 171 Query: 165 QRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLY 209 R+ D F G+ +I S+ + MA++ +L+VG + + G H+Y Sbjct: 172 MRANDAFRGIVSDIFSFTFIQEFMARELNLKVGKYYHSVGTMHIY 216 >UniRef50_C4SF99 Deoxyuridylate hydroxymethyltransferase n=1 Tax=Yersinia mollaretii ATCC 43969 RepID=C4SF99_YERMO Length = 335 Score = 67.0 bits (162), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 51/206 (24%), Positives = 98/206 (47%), Gaps = 10/206 (4%) Query: 37 NLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYL-HENNVTIWDEWADENGDLGPVYG 95 N ++ F ++ ++ ++ + + E +W L G ++ +L H +I E++D+N YG Sbjct: 20 NPRERFLVIPERKNNVFAQLAETIWVLAGRGDLEFLQHYLPRSI--EFSDDNKTWRAAYG 77 Query: 96 KQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWN-VGELDKMALAPCHAFFQFYV 154 + R W DQ++ V+++L+ DP+++R ++S ++ + + PC+ + QF Sbjct: 78 PRLRNWMGK----TDQVSCVISRLQEDPNTKRAVMSLFDPMSDYSDTKDVPCNNWLQFIQ 133 Query: 155 ADGKLSCQLYQRSCDVFLGLP-FNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHM 213 D L + R+ D G N +++L ++A +VG W G H+YS H Sbjct: 134 RDNILYLHVTVRANDAIWGFSGINFFEWSVLHEIVATTLGYQVGTLSWYVGTFHIYSRHY 193 Query: 214 DQTHLQLSREPRPLPKLIIKRKPESI 239 + T L R P +P SI Sbjct: 194 N-TSRDLLRIKNPKSPYECGIEPTSI 218 >UniRef50_C9KVG6 Thymidylate synthase n=14 Tax=Bacteroidales RepID=C9KVG6_9BACE Length = 233 Score = 67.0 bits (162), Expect = 6e-10, Method: Compositional matrix adjust. Identities = 52/221 (23%), Positives = 97/221 (43%), Gaps = 20/221 (9%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL 60 M +Y + + K+L G + +R G + ++ D + + + + EL Sbjct: 22 MNKYYQTLDKILQTGKIQTNRKGR-IKYLLNERLMLTPADLLDIFESHGIARKKLKEELK 80 Query: 61 WFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLK 120 F+QG ++ E +T WD + P Y ++ + + T +N+ K Sbjct: 81 LFMQGVRDVEKYKEAGITWWDYCGHTLVNSYPTYFEK-----------LPPLITRINREK 129 Query: 121 NDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIAS 180 + + + + V + APC + QF + +G+L YQRS D LGLP +I Sbjct: 130 RNSKNYVLFLGETGV----ESNQAPCLSLVQFQIDEGELVLSAYQRSSDANLGLPADIYH 185 Query: 181 YALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLS 221 +++MA+Q +L + G+ H+Y N++D+T LS Sbjct: 186 ----LYLMARQVELPLKSITLDLGNVHIYENNIDRTLELLS 222 >UniRef50_P31654 Deoxyuridylate hydroxymethyltransferase n=2 Tax=Bacillus phage SPO1 RepID=DUHM_BPSP1 Length = 383 Score = 66.6 bits (161), Expect = 9e-10, Method: Compositional matrix adjust. Identities = 50/210 (23%), Positives = 98/210 (46%), Gaps = 18/210 (8%) Query: 56 IHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRH-----ID 110 + E LW L G +++ +L + N + +++D+ YG++ R W D + +D Sbjct: 65 VAESLWILAGRSDVGFLLDYNKNM-GQFSDDGVFFNAPYGERLRFWNRSDANNFIYNPLD 123 Query: 111 QITTVLNQLKNDPDSRRIIVSAWNV---GELDKMALAPCHAFFQFYVADGKLSCQLYQRS 167 Q+ V ++K DPD+R+ + +N + PC+ F + +GKL +Y RS Sbjct: 124 QLRDVYEKIKADPDTRQAVAVIYNPLFDNINNDTKDRPCNLLLSFKLRNGKLDLSVYNRS 183 Query: 168 CDVFLG-LPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRP 226 D+ G N+ ++ ++ MA +EVG + H+Y +D +++ + + Sbjct: 184 NDLHWGTFGANLCQFSTILEAMATWLGVEVGSYYQITDSLHVY---LDDYGAKITEDIQK 240 Query: 227 LPKLIIKRKPESIFDYRFEDFEIEGYDPHP 256 + + ++ + EDFE E DP+P Sbjct: 241 VYGVNLETDEAPV----VEDFE-ELLDPNP 265 >UniRef50_B5UXF4 Thymidylate synthase n=1 Tax=Bacillus cereus AH1134 RepID=B5UXF4_BACCE Length = 326 Score = 65.9 bits (159), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 39/161 (24%), Positives = 77/161 (47%), Gaps = 7/161 (4%) Query: 58 ELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLN 117 E W + G + L+ N + +D ++D+ L YG + R +DQ+ + Sbjct: 69 EFSWIITGSNRLTPLN-NFINDFDRFSDDGFTLNGAYGHRLREL-----HGLDQLEKSIR 122 Query: 118 QLKNDPDSRRIIVSAWNVGELDKMAL-APCHAFFQFYVADGKLSCQLYQRSCDVFLGLPF 176 L+ + +RR++++ W++ +L + PC+ + + L + RS D+FLG+P+ Sbjct: 123 ILQEEKSTRRVVLTMWHIDDLGSNSRDIPCNISIMLKIRNNLLDMTVINRSNDLFLGVPY 182 Query: 177 NIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTH 217 N+ + LL +A++ +VG HLYS H ++ Sbjct: 183 NVVVFYLLQCYIAKKIGCKVGVQRHFTDSLHLYSQHFEKVQ 223 >UniRef50_B0T6R4 Thymidylate synthase n=1 Tax=Caulobacter sp. K31 RepID=B0T6R4_CAUSK Length = 367 Score = 65.9 bits (159), Expect = 1e-09, Method: Compositional matrix adjust. Identities = 44/189 (23%), Positives = 86/189 (45%), Gaps = 12/189 (6%) Query: 43 PLVTTKRCHLR----SIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQW 98 P R H++ S I E +W++ + + E ++ + ++A+++G + YG Sbjct: 46 PRARLSRAHMKGHVFSCIGEFIWYISCSNRLEPV-EYYISRYKKFAEKDGTVWGAYG--- 101 Query: 99 RAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGE-LDKMALAPCHAFFQFYVADG 157 P G Q V L P +R+ ++ ++ + L PC QF V DG Sbjct: 102 ---PRIFGGDRSQYEVVKEMLSERPSTRKAVIQLFDREDVLQDYNDIPCTCTMQFLVRDG 158 Query: 158 KLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTH 217 L+ ++ RS DV++GLP +I ++ ++ ++A ++G + G HLY + ++ Sbjct: 159 MLNLVVHMRSNDVYMGLPHDIFAFTMIQEILAHDLGFKLGTYKHMVGSFHLYDHDREKVE 218 Query: 218 LQLSREPRP 226 L +P Sbjct: 219 QYLKEGFQP 227 >UniRef50_UPI00016AEAE5 thymidylate synthase n=1 Tax=Burkholderia thailandensis MSMB43 RepID=UPI00016AEAE5 Length = 288 Score = 65.5 bits (158), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 52/216 (24%), Positives = 99/216 (45%), Gaps = 12/216 (5%) Query: 8 MQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHL-RSIIHELLWFLQGD 66 + ++ EG + R G ++ + + + L+D V + R R + ELL + G Sbjct: 34 IHNIVKEGRKIKSRAGD---AMQAYGVNYILKDPRSRVHSLRNGAKRYLCRELLAYFSGS 90 Query: 67 TNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSR 126 N W D++G++ YG + + P ++ +Q +++ LK++ DSR Sbjct: 91 LKAENGLANASKFWMTLTDKDGNVNSNYG--YYVFYEPVEKYGNQYNWIVSMLKSNQDSR 148 Query: 127 RIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYAL--- 183 R I++ PC QF++ + L C+ RS DV GLP+++ ++ Sbjct: 149 RAIININQNYHKSDTKDFPCTIGMQFFIRENHLFCETISRSTDVITGLPYDMGFFSFVHE 208 Query: 184 LVH--MMAQQC-DLEVGDFVWTGGDTHLYSNHMDQT 216 LVH +++Q DL++G + T +Y N M++ Sbjct: 209 LVHSDLVSQGYDDLQLGSTIMKTTFTQIYDNAMEKA 244 >UniRef50_B4TEI9 Thymidylate synthase n=2 Tax=Enterobacteriaceae RepID=B4TEI9_SALHS Length = 326 Score = 65.1 bits (157), Expect = 3e-09, Method: Compositional matrix adjust. Identities = 52/215 (24%), Positives = 97/215 (45%), Gaps = 13/215 (6%) Query: 9 QKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTN 68 Q +L +G ND T TL I G + T R L S + E LW+L + Sbjct: 19 QAILADGLS-NDPTKGSTLEILGAYLVLTDPRRRISRTESRGKLISCLGEFLWYLSAQND 77 Query: 69 IAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRI 128 + ++ ++ + + E A+ +G + YG + G + +Q+ V+N L+ +RR Sbjct: 78 LEFI-KHFIPRYAESAESDGKIHGGYGPRLFNM---RGLY-NQLKNVINLLQEKKPTRRA 132 Query: 129 IVSAWNVGEL-------DKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASY 181 ++ ++ +L + PC QF V +L + RS D F+GLP ++ ++ Sbjct: 133 VIQLFDASDLVPSKTEQREYVDIPCTISMQFIVRCEELHLFVCMRSNDAFMGLPHDVFAF 192 Query: 182 ALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQT 216 +L ++A+ E+G + HLY N +++ Sbjct: 193 TMLQELVARLIGCELGHYHHFVSSLHLYKNDLEKV 227 >UniRef50_C7JA78 Os12g0446900 protein (Fragment) n=1 Tax=Oryza sativa Japonica Group RepID=C7JA78_ORYSJ Length = 89 Score = 63.9 bits (154), Expect = 5e-09, Method: Compositional matrix adjust. Identities = 29/52 (55%), Positives = 41/52 (78%) Query: 151 QFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWT 202 +FYV +G+LSCQ+YQRS D+ LG+PFNIASY+LL M+AQ C + +++T Sbjct: 32 KFYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCGMFSLAYLFT 83 >UniRef50_C8S1P3 Thymidylate synthase n=1 Tax=Rhodobacter sp. SW2 RepID=C8S1P3_9RHOB Length = 358 Score = 63.2 bits (152), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 43/161 (26%), Positives = 73/161 (45%), Gaps = 9/161 (5%) Query: 54 SIIHELLWFLQGDTNIAYLHE---NNVTIWDEWADENGDLGP-VYGKQWRAWPTPDGRHI 109 S + EL W+L G + ++ N + + NG GP ++GK+ A DG Sbjct: 64 SPLGELFWYLSGSDRVEFIKHYIPNYPKLIKDEVTANGAYGPRIFGKE--ALAKRDG--A 119 Query: 110 DQITTVLNQLKNDPDSRRIIVSAW-NVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSC 168 + V+ L+ SR +V + N K PC QF + +G+L + RS Sbjct: 120 SEWDRVIRTLREREGSRNALVQIYDNSDAKPKNGDKPCTCTIQFAIRNGQLLMHTHMRSN 179 Query: 169 DVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLY 209 D F GLP ++ ++ +L + A++ L +G + + HLY Sbjct: 180 DAFFGLPHDVFTFTMLQEIAARELGLGLGRYSHSVTSLHLY 220 >UniRef50_B4Y380 MilA n=1 Tax=Streptomyces rimofaciens RepID=B4Y380_9ACTO Length = 334 Score = 63.2 bits (152), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 47/170 (27%), Positives = 76/170 (44%), Gaps = 7/170 (4%) Query: 45 VTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTP 104 V +R ++ E LW+L G + ++ I AD G YG R + P Sbjct: 55 VPARRANVVFNFAEALWYLSGSDRLDFIQYYAPGIAAYSADGRTLRGTAYGP--RIFRHP 112 Query: 105 DGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGEL---DKMALAPCHAFFQFYVADGKLSC 161 G ++Q V+ L +DPDS+R ++ ++ EL D + +A C QF + DG L Sbjct: 113 AG-GVNQWENVVKTLTDDPDSKRAVIQIFDPRELAVADNIDVA-CTLALQFLIRDGLLCG 170 Query: 162 QLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSN 211 Y R+ D F G ++ S+ L A+ L +G + G H+Y + Sbjct: 171 IGYMRANDAFRGAVSDVFSFTFLQEFTARYLGLGIGTYHHVVGSVHIYDS 220 >UniRef50_Q2FCV1 Thymidylate synthase n=2 Tax=Acinetobacter baumannii RepID=Q2FCV1_ACIBA Length = 222 Score = 61.6 bits (148), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 44/181 (24%), Positives = 85/181 (46%), Gaps = 29/181 (16%) Query: 45 VTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWA----DEN----GDLGP-VYG 95 ++ R L S I E W+L G ++ ++ E ++ + ++ DEN G GP ++G Sbjct: 52 ISETRSKLISCIGEFFWYLNGSDSLEFI-EYYISDYRKYIEYQIDENKPALGAYGPRIFG 110 Query: 96 KQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGEL--DKMALAPCHAFFQFY 153 Q +Q ++ LK+ P SRR ++S ++ +L + PC QF+ Sbjct: 111 AQ------------NQFNKIIEVLKDKPTSRRAVISIYSKDDLLREDSRDIPCTCLLQFF 158 Query: 154 VADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQC-----DLEVGDFVWTGGDTHL 208 + + +L RS D +GL +I S+ L+ ++ + +L++G++ G H+ Sbjct: 159 IRNERLHLTATMRSNDAAIGLVHDIFSFTLIQELLLAKLIRYIPNLQLGEYTHIVGSLHI 218 Query: 209 Y 209 Y Sbjct: 219 Y 219 >UniRef50_C8XUG3 Putative thymidylate synthase n=1 Tax=Shigella phage phiSboM-AG3 RepID=C8XUG3_9CAUD Length = 348 Score = 61.6 bits (148), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 46/196 (23%), Positives = 87/196 (44%), Gaps = 23/196 (11%) Query: 37 NLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGK 96 +++D + V + + I E W L G +I +L + A+ + D G Sbjct: 50 DIRDRWLSVEGRNSSAIAAIGETFWVLSGRNDIKFLSR----VLPRAANFSDD-----GV 100 Query: 97 QWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAP----------- 145 WRA P Q+ +V+N+L+ +P++R+ ++ ++ LA Sbjct: 101 TWRAAYGPRLYAHGQLDSVINRLRKNPNTRQAYLTIYDPALDSDAGLAKFSESGEAKTKD 160 Query: 146 --CHAFFQFYVADGKLSCQLYQRSCDVFLGLP-FNIASYALLVHMMAQQCDLEVGDFVWT 202 C+ F + DG+L+ + RS DV G+ N +++L ++AQ D++VG + Sbjct: 161 MVCNLALLFAIVDGRLNLTVINRSQDVLWGMSSINFIEFSILQEVIAQVLDVDVGQYKLF 220 Query: 203 GGDTHLYSNHMDQTHL 218 + H Y+N + Q L Sbjct: 221 SNNLHYYNNEVSQKQL 236 >UniRef50_Q5DN81 Thymidylate synthase n=3 Tax=unclassified Siphoviridae RepID=Q5DN81_9CAUD Length = 350 Score = 60.1 bits (144), Expect = 7e-08, Method: Compositional matrix adjust. Identities = 50/193 (25%), Positives = 86/193 (44%), Gaps = 27/193 (13%) Query: 56 IHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTV 115 + E LW L G ++A++ + + ++D+ + YG +WR + DQ++ Sbjct: 66 LFEALWMLAGRHDLAFVEKFAKNM-RSFSDDGETMWGAYGWRWRTF-----FDFDQLSWA 119 Query: 116 LNQLKNDPDSRRIIVSAWNVGELDKMALA-----PCHAFFQFYVAD-GKLSCQLYQRSCD 169 +++L+ P+ RR++V W G + A A PC+ F + D G+L ++ RS D Sbjct: 120 VHRLRRLPNDRRVVVQMWAAGLDQERADAGGKDVPCNIAIHFRINDRGQLDMTVWNRSND 179 Query: 170 VFLG-LPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYS---NHM-----------D 214 + G N+ ++L +A +EVG + D H YS N M D Sbjct: 180 IIWGAYGANVVHMSILQEYVASAVGVEVGRYWQVSDDYHAYSDLFNKMLPLMSASGVAPD 239 Query: 215 QTHLQLSREPRPL 227 +L EP PL Sbjct: 240 DMYLAGVSEPTPL 252 >UniRef50_B2ZYD3 Deoxyuridylate hydroxymethyltransferase n=1 Tax=Ralstonia phage RSL1 RepID=B2ZYD3_9CAUD Length = 414 Score = 58.2 bits (139), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 42/175 (24%), Positives = 76/175 (43%), Gaps = 29/175 (16%) Query: 56 IHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHI--DQIT 113 + E LW L G ++ + + E+ D+ L YG +WR +H DQ+ Sbjct: 108 LMEALWMLAGRNDVEFASYYAKQML-EYTDDGSTLNGAYGFRWR-------QHFGYDQLN 159 Query: 114 TVLNQLKNDPDSRRIIVSAWNV-----GELDKMALA-------------PCHAFFQFYVA 155 ++++LK +P SRR ++ W+ D A+ PC+ F Sbjct: 160 AIIDELKKNPASRRCVLQMWDASREFYSREDSWAVRRESDLLNQGSKDLPCNTSVMFDAQ 219 Query: 156 DGKLSCQLYQRSCDVFLG-LPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLY 209 GKL+ + RS D+ G N+ +++L +A++C L +G + + H+Y Sbjct: 220 LGKLNMTVTNRSNDMIWGCYGANVVHFSMLHEYVAEKCGLPLGHYYQVSNNLHVY 274 >UniRef50_B2TJD1 Thymidylate synthase n=1 Tax=Clostridium botulinum B str. Eklund 17B RepID=B2TJD1_CLOBB Length = 333 Score = 57.4 bits (137), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 46/197 (23%), Positives = 88/197 (44%), Gaps = 14/197 (7%) Query: 56 IHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTV 115 + EL+W + G+ ++ N ++ +++A YGK+ R+ DQI Sbjct: 66 LAELVWIINGEEKSDIINMWNPSL-EKYAGRGDIYHGAYGKRIRS-----HFGFDQIEKA 119 Query: 116 LNQLKNDPDSRRIIVSAWNVG-------ELDKMALAPCHAFFQFYVADGKLSCQLYQRSC 168 L+N P+SR++++ ++ + + PC+ V +GKL RS Sbjct: 120 YEALQNTPESRQVVIQIYDTKVDFPIEKGIPQDEDIPCNICSLLKVRNGKLEWSQIMRSN 179 Query: 169 DVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLP 228 DV LG+P+N + L ++A +L++G + HLY+ +++ + E R Sbjct: 180 DVLLGMPYNFIQFTGLQEILAGWLELDLGSYNHYSDSLHLYARDINKIGIGQEVEIRNND 239 Query: 229 KLIIKR-KPESIFDYRF 244 L + R + E +F F Sbjct: 240 SLSLSRNESERLFQEIF 256 >UniRef50_Q7Y590 Putative uncharacterized protein RB69ORF048c n=3 Tax=unclassified T4-like viruses RepID=Q7Y590_BPR69 Length = 238 Score = 57.4 bits (137), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 34/115 (29%), Positives = 57/115 (49%), Gaps = 9/115 (7%) Query: 107 RHIDQITTVLNQLKNDPDSRRIIV-----SAWNVGELDKMALAPCHAFFQFYVADGKL-- 159 R Q+ +L +LK P+SRR++ S + + D+ PC +Y+ DGKL Sbjct: 119 RIAAQLPALLKELKEKPNSRRVVFQILESSDQALLDSDETLEYPCTDSVTYYIRDGKLYT 178 Query: 160 SCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMD 214 C + ++C V + L F + L+H +A +C +EVGD+ T H++ D Sbjct: 179 HCHMRSQNCAVVMQLDFYLQ--GKLLHYIANECGVEVGDYTHTMVSAHVFERDFD 231 >UniRef50_Q2T5Q0 Deoxyuridylate hydroxymethyltransferase , putative n=20 Tax=Burkholderia RepID=Q2T5Q0_BURTA Length = 329 Score = 55.8 bits (133), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 42/192 (21%), Positives = 86/192 (44%), Gaps = 14/192 (7%) Query: 58 ELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLN 117 E LW+L G ++ ++ ++ D G YG + + R +DQI L+ Sbjct: 66 EALWYLSGRNDLEFIEHYAPSMARYSPDGKHLPGTGYGARLMHY---GARALDQIERALD 122 Query: 118 QL-KNDPDSRRIIVSAWNVGE--LDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGL 174 L ++D +S+R+++ ++ E + C Q + +G+L + R+ D ++GL Sbjct: 123 ILSRDDAESKRVVLQIFSADEDLYRRNIDVSCTLGLQLLLREGRLHMVAFMRANDAYVGL 182 Query: 175 PFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNH-------MDQTHLQLSREPRPL 227 ++ S+ L +A + D E+G + G H+Y ++ +D + Q+ P Sbjct: 183 LNDVFSFTFLQEYVATRLDCEIGAYSHHVGSIHVYDDNLPRALALLDDSDAQIVTAAAP- 241 Query: 228 PKLIIKRKPESI 239 P++ P +I Sbjct: 242 PRMPAGTSPATI 253 >UniRef50_Q21ZJ9 Thymidylate synthase n=1 Tax=Rhodoferax ferrireducens T118 RepID=Q21ZJ9_RHOFD Length = 347 Score = 54.3 bits (129), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 46/170 (27%), Positives = 72/170 (42%), Gaps = 13/170 (7%) Query: 56 IHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTV 115 I E++W L G +L+ N + ++A G YG + R T G +DQI V Sbjct: 67 IAEVIWILLGSDASNFLNFWNPVL-PKYAGSGGTYHGAYGARLR---THFG--LDQIERV 120 Query: 116 LNQLKNDPDSRRIIVSAWNVGE-------LDKMALAPCHAFFQFYVADGKLSCQLYQRSC 168 L +P+SR+ ++ W+ E + PC+ V KL RS Sbjct: 121 YQILSANPESRQAVLQIWDSREDLPLSDGASRDLDIPCNLVGMLKVRAQKLEWLQIMRSN 180 Query: 169 DVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHL 218 DVFLG P N+ + L ++A + +G F HLY + D+ + Sbjct: 181 DVFLGTPHNLVQFTSLQEIIAGWLGIGIGSFSLVTDSLHLYEHDYDRCSM 230 >UniRef50_Q5D6W4 Thymidylate synthase-like protein n=3 Tax=Enterobacteriaceae RepID=Q5D6W4_ECOLX Length = 105 Score = 53.9 bits (128), Expect = 5e-06, Method: Compositional matrix adjust. Identities = 24/48 (50%), Positives = 34/48 (70%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTK 48 M Y +L+++V+ GT DRTG GT+SI+G ++FNLQ+GFP T K Sbjct: 1 MDNYKDLLREVIITGTDSVDRTGVGTVSIWGAMLKFNLQEGFPATTCK 48 >UniRef50_C9DGK1 Deoxyuridylate hydroxymethyltransferase n=1 Tax=Deftia phage phiW-14 RepID=C9DGK1_9CAUD Length = 357 Score = 52.8 bits (125), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 51/229 (22%), Positives = 90/229 (39%), Gaps = 35/229 (15%) Query: 15 GTQKNDRTGTGTLSIFGHQMRFNLQDGFP-----LVTTKRCHLRSIIHELLWFLQGDTNI 69 G K R G T F ++F++ D P + ++ ++ ++ E W + G NI Sbjct: 27 GQYKECRNGGST---FLRNVKFHITD--PRNRNLTLNGRKSNIFQMVAETFWVMSGSGNI 81 Query: 70 AYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRII 129 E + +++D+ G W P +Q+ + ++ L D D+RR Sbjct: 82 KEFLEFFLPRAPQYSDD--------GINWHGAYGPRMYAHNQLQSAIDLLIKDKDTRRAY 133 Query: 130 V--------------SAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGL- 174 V +A+ VG K PC+ + + KL ++ QRS D+ G Sbjct: 134 VMIADPTLDSAPAIEAAYGVGHSPKDV--PCNREIHINIIEDKLCMKVIQRSGDMLFGTG 191 Query: 175 PFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSRE 223 N + L ++++ +GD+ W D H Y DQ + L E Sbjct: 192 SINPFEFTFLQELLSEATGYALGDYQWDVTDAHYYKAFEDQVNDVLRSE 240 >UniRef50_Q46E28 Putative thymidylate synthase n=5 Tax=Methanosarcinales RepID=TYSY_METBF Length = 217 Score = 52.8 bits (125), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 34/126 (26%), Positives = 52/126 (41%), Gaps = 4/126 (3%) Query: 89 DLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHA 148 D YG++ R W +DQI V+ +L+ +P SRR I W K+ PC Sbjct: 86 DFEYTYGQRLRNWHGK----VDQIDYVIEKLQQNPTSRRAIAVTWIPPVDTKVNEVPCMM 141 Query: 149 FFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHL 208 F + DGK+ RS D P N+ + L+ +A + + G H+ Sbjct: 142 LDDFKIRDGKIHLTTLFRSHDFGGAYPANLYGLSKLLEYVADKVGTKPGTITTISISAHI 201 Query: 209 YSNHMD 214 Y + D Sbjct: 202 YDHDWD 207 >UniRef50_C5U4L9 Thymidylate synthase, methanogen type n=1 Tax=Methanocaldococcus infernus ME RepID=C5U4L9_9EURY Length = 212 Score = 52.4 bits (124), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 31/117 (26%), Positives = 58/117 (49%), Gaps = 1/117 (0%) Query: 94 YGKQWRAWPTPDGR-HIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQF 152 Y ++ R +P+ D + DQ++ V+ +LKN+ SRR ++S W K+ PC F Sbjct: 82 YYERIREYPSYDRKLKNDQLSYVIEKLKNNSTSRRAVISLWQPFIDQKVKDVPCLQHIGF 141 Query: 153 YVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLY 209 + + KL + RS D+ L N L ++A+ ++E+ ++ + H+Y Sbjct: 142 QLREDKLIMSVLFRSNDILLAFHSNALGLISLGELVAKSLEVELKEYNHFIYNAHIY 198 >UniRef50_UPI0001C33797 thymidylate synthase n=3 Tax=Cyanobacteria RepID=UPI0001C33797 Length = 504 Score = 51.6 bits (122), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 36/124 (29%), Positives = 58/124 (46%), Gaps = 11/124 (8%) Query: 94 YGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFY 153 YG++ R+W D QI V++ L +D +S R ++S W+V + D PC Sbjct: 277 YGQRLRSWFKKD-----QIQQVIDLLVSDINSSRAVMSLWDVNDYDNNDSPPCLNHIWIR 331 Query: 154 VADGKLSCQLYQRSCDVFLGLPFN-IASYALLVHMMAQ-----QCDLEVGDFVWTGGDTH 207 D +LS RS D+F P N + AL +H+M + L++G V H Sbjct: 332 TIDDELSLTATFRSNDMFSAWPSNAMGLRALQIHIMREIQNRINQKLKIGPLVTVSQSAH 391 Query: 208 LYSN 211 +Y++ Sbjct: 392 IYND 395 >UniRef50_Q52PP0 Putative thymidylate synthase n=1 Tax=Xanthomonas phage Xp15 RepID=Q52PP0_9CAUD Length = 273 Score = 50.4 bits (119), Expect = 7e-05, Method: Compositional matrix adjust. Identities = 34/145 (23%), Positives = 62/145 (42%), Gaps = 13/145 (8%) Query: 74 ENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAW 133 + + +W+ + +G YG+ W G+ + + V+ +L D DSRR I+ Sbjct: 79 KQHAKMWESVQNPDGTFNSNYGQFWF------GQQMG-VMKVVMELIRDQDSRRAIIPML 131 Query: 134 NVGELDKMAL-APCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMM---- 188 L + C F++ L ++ RS D GL +I ++++L H++ Sbjct: 132 TDDHLSPETVDTVCTEAVSFHIRHNTLYTSVHMRSSDQIFGLGTDIPTFSVLTHLVHGLL 191 Query: 189 -AQQCDLEVGDFVWTGGDTHLYSNH 212 A L+VG T +H+Y H Sbjct: 192 QANYPSLQVGSMTITAASSHIYERH 216 >UniRef50_UPI0001742C7A thymidylate synthase n=1 Tax=candidate division TM7 single-cell isolate TM7a RepID=UPI0001742C7A Length = 61 Score = 49.7 bits (117), Expect = 9e-05, Method: Composition-based stats. Identities = 24/60 (40%), Positives = 36/60 (60%), Gaps = 2/60 (3%) Query: 205 DTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 D H+Y NH++ QL+R+P L K+ I KP + + FED +E Y+ +P IK VA+ Sbjct: 4 DAHIYENHIEGLKEQLTRKPLKLAKIKIADKPFN--ELTFEDITLEDYESYPAIKFEVAV 61 >UniRef50_P18029 Deoxycytidylate 5-hydroxymethyltransferase n=10 Tax=T4-like viruses RepID=DCHM_BPT2 Length = 246 Score = 49.3 bits (116), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 51/208 (24%), Positives = 79/208 (37%), Gaps = 26/208 (12%) Query: 20 DRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTI 79 D+TG T+ I G F + F +++ EL W+ + + I Sbjct: 27 DKTGVKTIEIIG--ASFVADEPFIFGALNDEYIQ---RELEWYKSKSLFVKDIPGETPKI 81 Query: 80 WDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIV-----SAWN 134 W + A G++ YG W W + D L +L +PDSRR I+ S Sbjct: 82 WQQVASSKGEINSNYG--WAIWSEDNYAQYDM---CLAELGQNPDSRRGIMIYTRPSMQF 136 Query: 135 VGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDL 194 D M+ C Q+ + D K++ + RS DV G + A ++ + DL Sbjct: 137 DYNKDGMSDFMCTNTVQYLIRDKKINAVVNMRSNDVVFGFRNDYAWQKYVLDKLV--SDL 194 Query: 195 EVGD---------FVWTGGDTHLYSNHM 213 GD +W G H+YS H Sbjct: 195 NAGDSTRQYKAGSIIWNVGSLHVYSRHF 222 >UniRef50_O26868 Putative thymidylate synthase n=2 Tax=Methanothermobacter RepID=TYSY_METTH Length = 222 Score = 48.9 bits (115), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 28/101 (27%), Positives = 43/101 (42%) Query: 109 IDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSC 168 +DQ+ + +LKN +SRR + W+ E PC F + DG+L RS Sbjct: 109 VDQLDEAIRRLKNCTESRRATMVTWDPPEDTASDEVPCMILVDFKIRDGRLFTTALWRSH 168 Query: 169 DVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLY 209 D++ N A L +A + +EVG H+Y Sbjct: 169 DIYGAWFPNAVGLAYLADHVAAEVGVEVGHITIHSISAHIY 209 >UniRef50_A3CSY2 Thymidylate synthase n=3 Tax=Methanomicrobiales RepID=A3CSY2_METMJ Length = 241 Score = 47.0 bits (110), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 26/102 (25%), Positives = 46/102 (45%) Query: 108 HIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRS 167 H+DQI + +L+ +SRR + WN + + PC Q + +GKL ++ RS Sbjct: 103 HVDQIDYIARKLEQAANSRRAVAVTWNPVVDENLDDCPCLQLVQCLLRNGKLQMKVVFRS 162 Query: 168 CDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLY 209 D+ N+ + L M+A + + G + H+Y Sbjct: 163 NDILSAAGSNMYALVRLQKMIADRLGVPCGRYTHIALVPHIY 204 >UniRef50_B8GIB9 Thymidylate synthase, methanogen type n=1 Tax=Methanosphaerula palustris E1-9c RepID=B8GIB9_METPE Length = 244 Score = 47.0 bits (110), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 25/102 (24%), Positives = 47/102 (46%) Query: 108 HIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRS 167 +DQI ++ +L+ P +RR + WN +++ PC Q + DG L ++ RS Sbjct: 103 QVDQIAYIIRKLQEAPATRRALAITWNPVVDEQVKDCPCLQLVQCVIRDGALQMKVVFRS 162 Query: 168 CDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLY 209 D+ N+ + L M+A+ + +G + H+Y Sbjct: 163 NDMLTASGANMFALVHLQLMIAEALGVRIGRYTHIALVPHVY 204 >UniRef50_Q57931 Putative thymidylate synthase n=11 Tax=Methanococcales RepID=TYSY_METJA Length = 222 Score = 46.6 bits (109), Expect = 8e-04, Method: Compositional matrix adjust. Identities = 30/121 (24%), Positives = 50/121 (41%), Gaps = 6/121 (4%) Query: 94 YGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVG-----ELDKMALAPCHA 148 Y ++ +P D + I+QI ++ +L +SRR + WN D+ PC Sbjct: 83 YHQRLFEYPYADEK-INQIDYIIEKLNQQKNSRRAVAITWNPKIDIEVSRDERGSVPCLQ 141 Query: 149 FFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHL 208 QF + +GKL + RS D L N L +A++ + G + H+ Sbjct: 142 LVQFLIRNGKLYQTVIFRSNDALLAFVSNAIGLITLGEYIAKKVGVGYGTYTHHAISMHI 201 Query: 209 Y 209 Y Sbjct: 202 Y 202 >UniRef50_B7KFY9 Thymidylate synthase n=11 Tax=Cyanobacteria RepID=B7KFY9_CYAP7 Length = 512 Score = 45.8 bits (107), Expect = 0.001, Method: Compositional matrix adjust. Identities = 35/125 (28%), Positives = 56/125 (44%), Gaps = 11/125 (8%) Query: 93 VYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQF 152 YGK+ R+W D QI V+ +L D +S R ++S W+V + + PC Sbjct: 276 TYGKRLRSWFKQD-----QIEQVIKKLTLDINSSRAVMSLWDVHDHEGNDNPPCLNHIWL 330 Query: 153 YVADGKLSCQLYQRSCDVFLGLPFN-IASYALLVHMM-----AQQCDLEVGDFVWTGGDT 206 V + +LS RS D+F P N + AL H++ L++G + Sbjct: 331 RVVENELSLTATFRSNDMFSAWPANAMGLRALQQHILDNINQRASYSLKMGPLITVSQSA 390 Query: 207 HLYSN 211 H+YS+ Sbjct: 391 HIYSD 395 >UniRef50_D2BHQ5 Thymidylate synthase n=5 Tax=Dehalococcoides RepID=D2BHQ5_DEHSV Length = 217 Score = 40.4 bits (93), Expect = 0.061, Method: Compositional matrix adjust. Identities = 29/106 (27%), Positives = 51/106 (48%), Gaps = 3/106 (2%) Query: 106 GRHID-QITTVLNQLKNDP-DSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQL 163 G++++ QI V+ K ++ + ++ N LD + PC V GKL + Sbjct: 97 GQYLEAQIAKVIKMYKETGFNTNQAFMTVGNPETLD-LEDPPCLRSIDTRVRYGKLHFII 155 Query: 164 YQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLY 209 Y RS D++ G P N+A+ +L MA + +E G+ + H+Y Sbjct: 156 YFRSWDLWAGFPSNLAAIQMLKEYMAAEIGVEDGEIIAMSKGMHIY 201 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_C0ZI91 Thymidylate synthase n=24 Tax=cellular organisms... 426 e-118 UniRef50_P04818 Thymidylate synthase n=326 Tax=root RepID=TYSY_H... 388 e-107 UniRef50_C5BMA3 Thymidylate synthase n=8 Tax=cellular organisms ... 386 e-106 UniRef50_Q4U9G5 Bifunctional dihydrofolate reductase/thymidilate... 369 e-101 UniRef50_Q2TA32 Thymidylate synthase n=5 Tax=cellular organisms ... 369 e-101 UniRef50_Q4A320 Bifunctional dihydrofolate reductase-thymidylate... 369 e-101 UniRef50_Q07422 Thymidylate synthase n=6 Tax=cellular organisms ... 368 e-100 UniRef50_Q1Q8B2 Thymidylate synthase n=702 Tax=root RepID=TYSY_P... 366 e-100 UniRef50_C3RUB2 Dihydrofolate reductase-thymidylate synthase n=1... 363 3e-99 UniRef50_O02604 Thymidylate synthase n=87 Tax=Plasmodium RepID=D... 363 4e-99 UniRef50_Q4A611 Thymidylate synthase n=15 Tax=Mollicutes RepID=T... 361 2e-98 UniRef50_A9NG27 Thymidylate synthase n=12 Tax=cellular organisms... 361 2e-98 UniRef50_C4Q3X9 Thymidylate synthase n=3 Tax=root RepID=C4Q3X9_S... 358 1e-97 UniRef50_Q27828 Thymidylate synthase n=1 Tax=Paramecium tetraure... 358 1e-97 UniRef50_D2CLW7 Dihydrofolate reductase-thymidylate synthase n=7... 356 4e-97 UniRef50_Q27783 Thymidylate synthase n=25 Tax=Trypanosomatidae R... 354 2e-96 UniRef50_D2W4C0 Predicted protein n=1 Tax=Naegleria gruberi RepI... 349 4e-95 UniRef50_Q27713 Thymidylate synthase n=5 Tax=Plasmodium RepID=DR... 349 6e-95 UniRef50_B1C3H3 Thymidylate synthase n=6 Tax=Bacteria RepID=B1C3... 346 4e-94 UniRef50_Q67JQ1 Thymidylate synthase n=1 Tax=Symbiobacterium the... 345 9e-94 UniRef50_O96650 Thymidylate synthase n=17 Tax=root RepID=TYSY_ASCSU 345 1e-93 UniRef50_B6AE97 Thymidylate synthase family protein n=4 Tax=cell... 344 2e-93 UniRef50_Q98Q31 Thymidylate synthase n=2 Tax=root RepID=TYSY_MYCPU 343 3e-93 UniRef50_Q9UTI7 Probable thymidylate synthase n=17 Tax=cellular ... 339 5e-92 UniRef50_Q0FG99 Thymidylate synthase n=4 Tax=root RepID=Q0FG99_9... 334 2e-90 UniRef50_Q8WYK3 Thymidylate synthase n=4 Tax=Eutheria RepID=Q8WY... 333 6e-90 UniRef50_Q76YC2 DTMP synthase n=1 Tax=Aeromonas phage Aeh1 RepID... 328 2e-88 UniRef50_Q04FR4 Thymidylate synthase n=279 Tax=cellular organism... 328 2e-88 UniRef50_P00471 Thymidylate synthase n=17 Tax=T4-like viruses Re... 327 3e-88 UniRef50_Q3J0W9 Thymidylate synthase n=12 Tax=Bacteria RepID=TYS... 324 1e-87 UniRef50_A2R2F6 Thymidylate synthase n=20 Tax=Leotiomyceta RepID... 320 3e-86 UniRef50_Q4PBV6 Thymidylate synthase n=3 Tax=Dikarya RepID=Q4PBV... 319 5e-86 UniRef50_A5KSZ1 Thymidylate synthase n=1 Tax=candidate division ... 319 8e-86 UniRef50_Q2G6V6 Thymidylate synthase n=14 Tax=Bacteria RepID=TYS... 315 8e-85 UniRef50_Q6QGJ5 Putative thymidylate synthase n=1 Tax=Enterobact... 314 2e-84 UniRef50_D1BNV6 Thymidylate synthase n=4 Tax=Veillonellaceae Rep... 309 4e-83 UniRef50_D2XB64 Bifunctional dihydrofolate reductase-thymidylate... 309 4e-83 UniRef50_A3QU09 Thymidylate synthase n=1 Tax=Oryctes rhinoceros ... 306 5e-82 UniRef50_Q65J44 Thymidylate synthase n=9 Tax=root RepID=TYSY_BACLD 303 4e-81 UniRef50_A6M378 Thymidylate synthase n=8 Tax=Clostridium RepID=T... 302 1e-80 UniRef50_B2YFY9 Thymidylate synthase n=1 Tax=Musca domestica sal... 292 5e-78 UniRef50_Q88CN9 Thymidylate synthase n=74 Tax=Proteobacteria Rep... 290 3e-77 UniRef50_A9UZA9 Thymidylate synthase n=1 Tax=Monosiga brevicolli... 284 3e-75 UniRef50_B6FSV1 Putative uncharacterized protein n=1 Tax=Clostri... 282 6e-75 UniRef50_Q5UQG3 Thymidylate synthase n=1 Tax=Acanthamoeba polyph... 282 9e-75 UniRef50_A8RRN6 Thymidylate synthase n=16 Tax=Bacteria RepID=A8R... 281 1e-74 UniRef50_Q6WIC0 DTMP (Thymidylate) synthase n=1 Tax=Vibrio phage... 277 3e-73 UniRef50_C4Z7Z1 Thymidylate synthase n=19 Tax=Bacteria RepID=C4Z... 275 7e-73 UniRef50_UPI0001925B1E PREDICTED: similar to thymidylate synthas... 275 7e-73 UniRef50_D2RRK7 Thymidylate synthase n=9 Tax=cellular organisms ... 270 2e-71 UniRef50_A8H1B4 Thymidylate synthase n=132 Tax=root RepID=TYSY_S... 269 7e-71 UniRef50_Q8WYK4 Thymidylate synthase n=7 Tax=Fungi/Metazoa group... 268 1e-70 UniRef50_B9CJY5 Thymidylate synthase n=10 Tax=Bacteria RepID=B9C... 266 7e-70 UniRef50_B7C7C1 Putative uncharacterized protein n=1 Tax=Eubacte... 261 1e-68 UniRef50_Q8RGP6 Thymidylate synthase n=10 Tax=Fusobacterium RepI... 260 5e-68 UniRef50_Q934U8 Putative thymidylate synthase n=1 Tax=Salmonella... 257 3e-67 UniRef50_C3IV33 Thymidylate synthase n=2 Tax=Bacillus thuringien... 257 3e-67 UniRef50_B9LR89 Thymidylate synthase n=4 Tax=Halobacteriaceae Re... 256 5e-67 UniRef50_C5H7L6 Thymidylate synthase n=3 Tax=unclassified Myovir... 252 7e-66 UniRef50_C6JM98 Thymidylate synthase n=6 Tax=Fusobacterium RepID... 252 1e-65 UniRef50_A2SMX7 Thymidylate synthase n=1 Tax=Methylibium petrole... 242 1e-62 UniRef50_A8E2Q5 Putative thymidylate synthase n=1 Tax=Enterococc... 239 8e-62 UniRef50_B8QTX3 Putative thymidylate synthase n=1 Tax=Erwinia ph... 231 2e-59 UniRef50_C7HUX5 Thymidylate synthase n=2 Tax=Anaerococcus RepID=... 230 5e-59 UniRef50_Q6X183 Thymidylate synthase (Fragment) n=1 Tax=Enteroba... 210 6e-53 UniRef50_C0ELR2 Putative uncharacterized protein n=1 Tax=Neisser... 208 1e-52 UniRef50_Q7Y427 dTMP (Thymidylate) synthase n=3 Tax=unclassified... 208 2e-52 UniRef50_Q03LN3 Thymidylate synthase n=75 Tax=Firmicutes RepID=T... 207 3e-52 UniRef50_B4TEI9 Thymidylate synthase n=2 Tax=Enterobacteriaceae ... 196 6e-49 UniRef50_B2IB94 Thymidylate synthase n=2 Tax=Rhizobiales RepID=B... 188 1e-46 UniRef50_Q13T72 Thymidylate synthase n=4 Tax=Burkholderiaceae Re... 185 1e-45 UniRef50_B4Y380 MilA n=1 Tax=Streptomyces rimofaciens RepID=B4Y3... 181 2e-44 UniRef50_UPI00016AD9CB thymidylate synthase n=1 Tax=Burkholderia... 180 4e-44 UniRef50_A7TUR1 Putative thymidylate synthase n=3 Tax=Streptomyc... 180 4e-44 UniRef50_B0T6R4 Thymidylate synthase n=1 Tax=Caulobacter sp. K31... 180 5e-44 UniRef50_B3FJL1 Putative uncharacterized protein n=1 Tax=Pseudom... 179 6e-44 UniRef50_B5S769 Putative thymidylate synthase protein n=1 Tax=Ra... 177 4e-43 UniRef50_C4SF99 Deoxyuridylate hydroxymethyltransferase n=1 Tax=... 175 2e-42 UniRef50_P31654 Deoxyuridylate hydroxymethyltransferase n=2 Tax=... 173 7e-42 UniRef50_Q1ZMM6 Thymidylate synthase n=3 Tax=Gammaproteobacteria... 170 4e-41 UniRef50_B2HI72 Thymidylate synthase, ThyA_1 n=1 Tax=Mycobacteri... 168 2e-40 UniRef50_C8S1P3 Thymidylate synthase n=1 Tax=Rhodobacter sp. SW2... 167 3e-40 UniRef50_Q03W75 Thymidylate synthase n=13 Tax=Bacteria RepID=Q03... 163 4e-39 UniRef50_Q8MVZ9 Bifunctional dihydrofolate reductase-thymidylate... 163 5e-39 UniRef50_B5UXF4 Thymidylate synthase n=1 Tax=Bacillus cereus AH1... 163 7e-39 UniRef50_UPI00016AEAE5 thymidylate synthase n=1 Tax=Burkholderia... 160 5e-38 UniRef50_Q2T5Q0 Deoxyuridylate hydroxymethyltransferase , putati... 160 6e-38 UniRef50_Q2FCV1 Thymidylate synthase n=2 Tax=Acinetobacter bauma... 157 3e-37 UniRef50_B2ZYD3 Deoxyuridylate hydroxymethyltransferase n=1 Tax=... 156 8e-37 UniRef50_Q5DN81 Thymidylate synthase n=3 Tax=unclassified Siphov... 152 9e-36 UniRef50_Q21ZJ9 Thymidylate synthase n=1 Tax=Rhodoferax ferrired... 151 2e-35 UniRef50_C9DGK1 Deoxyuridylate hydroxymethyltransferase n=1 Tax=... 151 2e-35 UniRef50_B2TJD1 Thymidylate synthase n=1 Tax=Clostridium botulin... 151 3e-35 UniRef50_C9KVG6 Thymidylate synthase n=14 Tax=Bacteroidales RepI... 144 3e-33 UniRef50_C8XUG3 Putative thymidylate synthase n=1 Tax=Shigella p... 143 8e-33 UniRef50_Q46E28 Putative thymidylate synthase n=5 Tax=Methanosar... 137 4e-31 UniRef50_P18029 Deoxycytidylate 5-hydroxymethyltransferase n=10 ... 135 1e-30 UniRef50_C5U4L9 Thymidylate synthase, methanogen type n=1 Tax=Me... 133 7e-30 UniRef50_Q8MW00 Bifunctional dihydrofolate reductase-thymidylate... 128 1e-28 UniRef50_Q8MVZ8 Bifunctional dihydrofolate reductase-thymidylate... 128 1e-28 UniRef50_Q7Y590 Putative uncharacterized protein RB69ORF048c n=3... 128 2e-28 UniRef50_Q8MVZ6 Bifunctional dihydrofolate reductase-thymidylate... 128 3e-28 UniRef50_B8GIB9 Thymidylate synthase, methanogen type n=1 Tax=Me... 127 4e-28 UniRef50_O26868 Putative thymidylate synthase n=2 Tax=Methanothe... 127 5e-28 UniRef50_Q57931 Putative thymidylate synthase n=11 Tax=Methanoco... 123 8e-27 UniRef50_Q8MVZ5 Bifunctional dihydrofolate reductase-thymidylate... 123 8e-27 UniRef50_Q52PP0 Putative thymidylate synthase n=1 Tax=Xanthomona... 120 5e-26 UniRef50_A3CSY2 Thymidylate synthase n=3 Tax=Methanomicrobiales ... 118 2e-25 UniRef50_UPI0001C33797 thymidylate synthase n=3 Tax=Cyanobacteri... 117 3e-25 UniRef50_B7KFY9 Thymidylate synthase n=11 Tax=Cyanobacteria RepI... 109 7e-23 UniRef50_B9PCT2 Predicted protein (Fragment) n=2 Tax=root RepID=... 84 4e-15 UniRef50_C7JA78 Os12g0446900 protein (Fragment) n=1 Tax=Oryza sa... 80 5e-14 UniRef50_UPI0001742C7A thymidylate synthase n=1 Tax=candidate di... 77 6e-13 UniRef50_Q5D6W4 Thymidylate synthase-like protein n=3 Tax=Entero... 68 4e-10 Sequences not found previously or not previously below threshold: UniRef50_B3QQU8 Thymidylate synthase n=1 Tax=Chlorobaculum parvu... 125 2e-27 UniRef50_Q2NEY9 ThyA n=1 Tax=Methanosphaera stadtmanae DSM 3091 ... 108 2e-22 UniRef50_O28232 Thymidylate synthase, putative n=2 Tax=Archaeogl... 100 6e-20 UniRef50_Q8TVL9 Putative thymidylate synthase n=1 Tax=Methanopyr... 94 4e-18 UniRef50_Q2FKU7 Thymidylate synthase-like n=1 Tax=Methanospirill... 90 8e-17 UniRef50_A1RYR8 Thymidylate synthase-like protein n=1 Tax=Thermo... 88 2e-16 UniRef50_A2E1C8 Putative uncharacterized protein n=1 Tax=Trichom... 86 1e-15 UniRef50_UPI0001C42129 thymidylate synthase ThyA n=1 Tax=Methano... 86 2e-15 UniRef50_A5UP11 Predicted thymidylate synthase, ThyA n=2 Tax=Met... 85 2e-15 UniRef50_B8KML0 Putative thymidylate synthase n=1 Tax=gamma prot... 81 5e-14 UniRef50_D2BHQ5 Thymidylate synthase n=5 Tax=Dehalococcoides Rep... 81 5e-14 UniRef50_A5KRW4 Thymidylate synthase-like protein n=1 Tax=candid... 77 6e-13 UniRef50_B1ZRC5 Thymidylate synthase-like protein n=1 Tax=Opitut... 76 9e-13 UniRef50_D2B6A6 Putative uncharacterized protein n=1 Tax=Strepto... 70 6e-11 UniRef50_A9A0S4 Thymidylate synthase-like protein n=2 Tax=Desulf... 68 3e-10 UniRef50_C2KJS6 Possible thymidylate synthase n=1 Tax=Leuconosto... 67 5e-10 UniRef50_C0GRD7 Thymidylate synthase-like protein n=1 Tax=Desulf... 66 1e-09 UniRef50_D1YXV9 Thymidylate synthase n=2 Tax=Euryarchaeota RepID... 58 4e-07 UniRef50_B0YLJ0 Thymidylate synthase n=1 Tax=Glossina pallidipes... 55 2e-06 UniRef50_B5UXF2 Putative uncharacterized protein n=1 Tax=Bacillu... 55 4e-06 UniRef50_B0YLI9 Thymidylate synthase-like protein n=1 Tax=Glossi... 54 7e-06 UniRef50_Q82RC3 Putative uncharacterized protein n=2 Tax=Strepto... 54 7e-06 UniRef50_A5VDP1 Putative uncharacterized protein n=2 Tax=Alphapr... 44 0.004 UniRef50_C8SR56 Putative uncharacterized protein n=1 Tax=Mesorhi... 43 0.008 UniRef50_A8P7A1 Putative uncharacterized protein n=1 Tax=Brugia ... 40 0.061 UniRef50_C0LGV1 LRR receptor-like serine/threonine-protein kinas... 40 0.092 >UniRef50_C0ZI91 Thymidylate synthase n=24 Tax=cellular organisms RepID=TYSY_BREBN Length = 264 Score = 426 bits (1097), Expect = e-118, Method: Composition-based stats. Identities = 179/264 (67%), Positives = 215/264 (81%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL 60 MKQYL+L Q++LDEG K DRTGTGT S+FGHQMRF+L +GFP+VTTK+ H++SIIHELL Sbjct: 1 MKQYLDLCQRILDEGVIKEDRTGTGTTSVFGHQMRFDLSEGFPMVTTKKLHMKSIIHELL 60 Query: 61 WFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLK 120 WFL GDTN+ YL EN V IW+EWADENGDLGPVYG QWR++ DG+ +DQI V++++K Sbjct: 61 WFLSGDTNVRYLQENGVRIWNEWADENGDLGPVYGSQWRSFTGRDGKTVDQIQWVIDEIK 120 Query: 121 NDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIAS 180 +PDSRR+IVSAWN ELDKMAL PCH FQFYVA+GKLSCQLYQRS D FLG+PFNIAS Sbjct: 121 RNPDSRRLIVSAWNPAELDKMALPPCHLLFQFYVANGKLSCQLYQRSGDTFLGVPFNIAS 180 Query: 181 YALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIF 240 YALL HM+A LEVGDFV T GD HLY NH++Q LQL+REP+PLPKL++ SIF Sbjct: 181 YALLTHMVAHVTGLEVGDFVHTIGDAHLYLNHIEQVKLQLTREPKPLPKLVLNPDVTSIF 240 Query: 241 DYRFEDFEIEGYDPHPGIKAPVAI 264 D+++ED EI GY+ HP IK VA+ Sbjct: 241 DFKYEDIEIVGYESHPHIKGEVAV 264 >UniRef50_P04818 Thymidylate synthase n=326 Tax=root RepID=TYSY_HUMAN Length = 313 Score = 388 bits (998), Expect = e-107, Method: Composition-based stats. Identities = 144/282 (51%), Positives = 186/282 (65%), Gaps = 20/282 (7%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62 QYL +Q +L G +K+DRTGTGTLS+FG Q R++L+D FPL+TTKR + ++ ELLWF Sbjct: 32 QYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWF 91 Query: 63 LQGDTNIAYLHENNVTIWDEWAD------------ENGDLGPVYGKQWRAWPT------- 103 ++G TN L V IWD E GDLGPVYG QWR + Sbjct: 92 IKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEGDLGPVYGFQWRHFGAEYRDMES 151 Query: 104 -PDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQ 162 G+ +DQ+ V++ +K +PD RRII+ AWN +L MAL PCHA QFYV + +LSCQ Sbjct: 152 DYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSCQ 211 Query: 163 LYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSR 222 LYQRS D+ LG+PFNIASYALL +M+A L+ GDF+ T GD H+Y NH++ +QL R Sbjct: 212 LYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQR 271 Query: 223 EPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 EPRP PKL I RK E I D++ EDF+IEGY+PHP IK +A+ Sbjct: 272 EPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPHPTIKMEMAV 313 >UniRef50_C5BMA3 Thymidylate synthase n=8 Tax=cellular organisms RepID=TYSY_TERTT Length = 277 Score = 386 bits (991), Expect = e-106, Method: Composition-based stats. Identities = 165/277 (59%), Positives = 204/277 (73%), Gaps = 13/277 (4%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL 60 MKQYLELM+ V D G +K DRTGTGT+S+FG+QMRF+L GFPLVTTK+CHL+SIIHELL Sbjct: 1 MKQYLELMRHVRDNGVRKEDRTGTGTVSVFGYQMRFDLSQGFPLVTTKKCHLKSIIHELL 60 Query: 61 WFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLK 120 WFL G+TNIAYL+ N V IWD WA E+GDLGP+YG QWR+WP +G +DQI+ ++ Q+K Sbjct: 61 WFLNGETNIAYLNNNGVKIWDAWATESGDLGPIYGAQWRSWPAQNGETLDQISQLIEQIK 120 Query: 121 NDPDSRRIIVSAWNVGELD-------------KMALAPCHAFFQFYVADGKLSCQLYQRS 167 + PDSRR+I+SAWN L KMAL PCH FQFYV +G+LSCQLYQRS Sbjct: 121 HKPDSRRLIISAWNPALLPDESISPQDNVRNGKMALPPCHTLFQFYVLEGRLSCQLYQRS 180 Query: 168 CDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPL 227 D+FLG+PFNIASYALL M+AQ L GDFV T GD HLY NH++Q QL R+P PL Sbjct: 181 ADIFLGVPFNIASYALLTMMIAQVTGLAPGDFVHTFGDAHLYLNHLEQVDTQLQRQPLPL 240 Query: 228 PKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 P + I + IF + F+DFE++ Y HP I AP+++ Sbjct: 241 PTMAINPAVKDIFGFCFDDFELQNYQAHPHIAAPISV 277 >UniRef50_Q4U9G5 Bifunctional dihydrofolate reductase/thymidilate synthase, putative n=7 Tax=root RepID=Q4U9G5_THEAN Length = 523 Score = 369 bits (949), Expect = e-101, Method: Composition-based stats. Identities = 131/281 (46%), Positives = 181/281 (64%), Gaps = 20/281 (7%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62 QYLE++ +L+ G K +RTG ++ FG+QMRF+L FPL+TTK+ LR II EL+WF Sbjct: 242 QYLEILADILNNGYHKKNRTGVDCIAKFGYQMRFDLSQSFPLLTTKKVFLRGIIEELIWF 301 Query: 63 LQGDTNIAYLHENNVTIW-----DEWADENG-------DLGPVYGKQWRAWPT------- 103 ++G TN L + NV IW + D G DLGPVYG QWR + Sbjct: 302 IRGSTNGNELLKKNVRIWELNGARSFLDNLGFYDREEQDLGPVYGFQWRHFGAKYIDMHA 361 Query: 104 -PDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQ 162 + IDQ++ V+ ++KN+PD+RR+IV +WNV +L KMAL PCH FQF+VADG LSC Sbjct: 362 DYTDQGIDQLSLVIERIKNNPDNRRLIVCSWNVADLSKMALPPCHLLFQFFVADGTLSCM 421 Query: 163 LYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSR 222 ++QRSCD+ LG+PFNIASY+LL +M+A C L+ G+FV GD H+Y+NH+D Q+SR Sbjct: 422 MHQRSCDMGLGVPFNIASYSLLTYMIAHICGLKPGEFVHNLGDAHIYNNHIDAIKEQISR 481 Query: 223 EPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263 P P P L + ++ I D+ +D ++E Y HP IK +A Sbjct: 482 VPYPFPTLKLNKEITRIEDFTIDDIKVENYRCHPLIKMEMA 522 >UniRef50_Q2TA32 Thymidylate synthase n=5 Tax=cellular organisms RepID=TYSY_BOVIN Length = 354 Score = 369 bits (948), Expect = e-101, Method: Composition-based stats. Identities = 143/320 (44%), Positives = 188/320 (58%), Gaps = 58/320 (18%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62 QYL ++ +L G +++DRTGTGTLS+FG Q R+NL+D FPL+TTKR + ++ ELLWF Sbjct: 35 QYLGQIEHILRCGFRRDDRTGTGTLSVFGMQARYNLRDEFPLLTTKRVFWKGVLEELLWF 94 Query: 63 LQGDTNIAYLHENNVTIWDEWADEN------------GDLGPVYGKQWRAWPT------- 103 ++G TN L V IWD + GDLGPVYG QWR + Sbjct: 95 IKGSTNAKELSSKGVKIWDANGSRDFLDGLGFSDRAEGDLGPVYGFQWRHFGAEYKDMDS 154 Query: 104 -PDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQ 162 G+ +DQ+ V++ +K +P+ RRII+ AWN +L MAL PCHA QFYV +G+LSCQ Sbjct: 155 EYSGQGVDQLQKVIDTIKTNPNDRRIILCAWNPKDLPLMALPPCHALCQFYVVNGELSCQ 214 Query: 163 LYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQ--- 219 LYQRS D+ LG+PFNIASYALL +M+A DL+ GDFV T GD H+Y NH++ Q Sbjct: 215 LYQRSGDMGLGVPFNIASYALLTYMIAHITDLKPGDFVHTLGDAHIYLNHIEPLKTQALM 274 Query: 220 -----------------------------------LSREPRPLPKLIIKRKPESIFDYRF 244 L REPRP PKL I RK E+I D++ Sbjct: 275 ELRGQSSRSLDGDGQAGTSRWAPVATDTERDRCCELQREPRPFPKLKILRKVETIDDFQA 334 Query: 245 EDFEIEGYDPHPGIKAPVAI 264 EDF+IEGY+P+P IK +A+ Sbjct: 335 EDFQIEGYNPNPTIKMEMAV 354 >UniRef50_Q4A320 Bifunctional dihydrofolate reductase-thymidylate synthase n=2 Tax=dsDNA viruses, no RNA stage RepID=Q4A320_EHV86 Length = 480 Score = 369 bits (948), Expect = e-101, Method: Composition-based stats. Identities = 135/281 (48%), Positives = 178/281 (63%), Gaps = 20/281 (7%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62 QYL+L+ KVL+ G ++DRTGTGT+S+FG MRFNL FPL+TTKR + + I+ ELLWF Sbjct: 199 QYLQLISKVLEHGEYRSDRTGTGTVSLFGETMRFNLSTHFPLLTTKRTYWKGIVEELLWF 258 Query: 63 LQGDTNIAYLHENNVTIWDEWA------------DENGDLGPVYGKQWRAWPT------- 103 ++G TN L NV IWD +E GDLGPVYG QWR + Sbjct: 259 IRGSTNANELAAKNVKIWDGNGSRDFLDSVGLVDNEEGDLGPVYGFQWRHFGADYKTMHD 318 Query: 104 -PDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQ 162 D + DQ+ V++Q+KN+P SRRII+SAWN L+KMAL PCH QFYV DG LSCQ Sbjct: 319 SYDSQGTDQLQNVIDQIKNNPTSRRIIMSAWNPNALEKMALPPCHLMCQFYVHDGMLSCQ 378 Query: 163 LYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSR 222 +YQRS D+ LG+PFNIASYALL ++A +L+ G+F+ GD H+Y+NH+D QL R Sbjct: 379 MYQRSADIGLGVPFNIASYALLTCLIAHFTNLKPGEFIHVIGDAHVYTNHIDALKTQLKR 438 Query: 223 EPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263 +P P + I P++IFD +D + Y HP I ++ Sbjct: 439 KPYDFPTIHINNMPKTIFDVTSDDIILNDYKCHPKIHMDMS 479 >UniRef50_Q07422 Thymidylate synthase n=6 Tax=cellular organisms RepID=DRTS_TOXGO Length = 610 Score = 368 bits (945), Expect = e-100, Method: Composition-based stats. Identities = 126/285 (44%), Positives = 177/285 (62%), Gaps = 23/285 (8%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62 QYL+L+ +++ G +DRTG G +S FG MR++L FPL+TTKR + ++ ELLWF Sbjct: 326 QYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWF 385 Query: 63 LQGDTNIAYLHENNVTIWDEWADEN------------GDLGPVYGKQWRAW--------P 102 ++GDTN +L E V IWD+ GD+GP YG QWR + Sbjct: 386 IRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHT 445 Query: 103 TPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGK-LSC 161 G+ +DQ+ V+ L+ +P RR++++AWN LD+MAL PCH QFYV D K LSC Sbjct: 446 DYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSC 505 Query: 162 QLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLS 221 +YQRSCDV LG+PFNIASY+LL M+A C+L+ +F+ G+TH+Y+NH++ QL Sbjct: 506 IMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLR 565 Query: 222 REPRPLPKLII--KRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 REPRP P + I K + + I D+ EDFE+ GY PH I+ +A+ Sbjct: 566 REPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 610 >UniRef50_Q1Q8B2 Thymidylate synthase n=702 Tax=root RepID=TYSY_PSYCK Length = 290 Score = 366 bits (941), Expect = e-100, Method: Composition-based stats. Identities = 156/279 (55%), Positives = 201/279 (72%), Gaps = 16/279 (5%) Query: 2 KQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLW 61 + YL+L++ VL+EGT+K DRTGTGTLS FG Q+RFNL DGFPL+TTK+ HL+SI +ELLW Sbjct: 12 QAYLDLLRLVLNEGTEKGDRTGTGTLSHFGAQLRFNLADGFPLLTTKKVHLKSITYELLW 71 Query: 62 FLQGDTNIAYLHENNVTIWDEWADEN---------GDLGPVYGKQWRAWPT-------PD 105 FL G T++ YL +N V IW+EWA GDLGP+YG QWR + + Sbjct: 72 FLNGSTHVDYLQQNGVRIWNEWATSEQTARFNRPAGDLGPIYGHQWRNYGATTTADGQYN 131 Query: 106 GRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQ 165 +DQI V+ Q+K +P+SRR+IVS WN GE D++AL PCH FQF+VAD KLSCQLYQ Sbjct: 132 SDGVDQIAQVVEQIKTNPNSRRLIVSGWNPGEADQVALPPCHTLFQFFVADNKLSCQLYQ 191 Query: 166 RSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPR 225 RS D+FLG+PFNIASYA+L HM+AQ C+LEVG+F+WTGGD H+Y NH +Q LQL+R Sbjct: 192 RSADLFLGVPFNIASYAMLTHMVAQVCNLEVGEFIWTGGDCHIYQNHREQVELQLTRSLY 251 Query: 226 PLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 LP L + + IF + +ED ++GY+ HP IKA VA+ Sbjct: 252 TLPTLALNPNVKDIFAFNYEDISVDGYESHPAIKAQVAV 290 >UniRef50_C3RUB2 Dihydrofolate reductase-thymidylate synthase n=16 Tax=Plasmodium vivax RepID=C3RUB2_PLAVI Length = 630 Score = 363 bits (933), Expect = 3e-99, Method: Composition-based stats. Identities = 126/281 (44%), Positives = 176/281 (62%), Gaps = 20/281 (7%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62 QYL ++ ++ G ++ DRTG G +S FG+ M+FNL + FPL+TTK+ LR II ELLWF Sbjct: 349 QYLGIIYDIIMNGNKQGDRTGVGVMSKFGYMMKFNLSEYFPLLTTKKLFLRGIIEELLWF 408 Query: 63 LQGDTNIAYLHENNVTIWDEWADEN------------GDLGPVYGKQWRAWPT------- 103 ++G+TN L NV IW+ DLGP+YG QWR + Sbjct: 409 IRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYTNMHD 468 Query: 104 -PDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQ 162 + + +DQ+ V++ +KN+P SRRII+ AWNV +LD+MAL PCH QFYV DGKLSC Sbjct: 469 NYEDKGVDQLKNVIHLIKNEPTSRRIILCAWNVKDLDQMALPPCHILCQFYVFDGKLSCI 528 Query: 163 LYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSR 222 +YQRSCD+ LG+PFNIASY++ HM+AQ C+L+ F+ G+ H+Y+NH+D +QL+R Sbjct: 529 MYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQPAQFIHILGNAHVYNNHVDSLKVQLNR 588 Query: 223 EPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263 P P P L + + ++I D+ DF IE Y H I +A Sbjct: 589 IPYPFPTLKLNPEVKNIEDFTISDFTIENYVHHDKITMEMA 629 >UniRef50_O02604 Thymidylate synthase n=87 Tax=Plasmodium RepID=DRTS_PLAVI Length = 623 Score = 363 bits (931), Expect = 4e-99, Method: Composition-based stats. Identities = 126/281 (44%), Positives = 176/281 (62%), Gaps = 20/281 (7%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62 QYL ++ ++ G ++ DRTG G +S FG+ M+FNL + FPL+TTK+ LR II ELLWF Sbjct: 342 QYLGIIYDIIMNGNKQGDRTGVGVMSNFGYMMKFNLSEYFPLLTTKKLFLRGIIEELLWF 401 Query: 63 LQGDTNIAYLHENNVTIWDEWADEN------------GDLGPVYGKQWRAWPT------- 103 ++G+TN L NV IW+ DLGP+YG QWR + Sbjct: 402 IRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYTNMHD 461 Query: 104 -PDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQ 162 + + +DQ+ V++ +KN+P SRRII+ AWNV +LD+MAL PCH QFYV DGKLSC Sbjct: 462 NYEDKGVDQLKNVIHLIKNEPTSRRIILCAWNVKDLDQMALPPCHILCQFYVFDGKLSCI 521 Query: 163 LYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSR 222 +YQRSCD+ LG+PFNIASY++ HM+AQ C+L+ F+ G+ H+Y+NH+D +QL+R Sbjct: 522 MYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQPAQFIHILGNAHVYNNHVDSLKVQLNR 581 Query: 223 EPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263 P P P L + + ++I D+ DF IE Y H I +A Sbjct: 582 IPYPFPTLKLNPEVKNIEDFTISDFTIENYVHHDKITMEMA 622 >UniRef50_Q4A611 Thymidylate synthase n=15 Tax=Mollicutes RepID=TYSY_MYCS5 Length = 289 Score = 361 bits (926), Expect = 2e-98, Method: Composition-based stats. Identities = 157/294 (53%), Positives = 203/294 (69%), Gaps = 35/294 (11%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL 60 MKQYL L++ + GT K DRT GT+S+FG Q R+NL++GFPL+TTK+ ++I HELL Sbjct: 1 MKQYLHLLEHIKTSGTFKKDRTNIGTISLFGLQARYNLKEGFPLLTTKKMAWKAICHELL 60 Query: 61 WFLQGDTNIAYLHENNVTIWDEW-----------------------------ADENGDLG 91 WFL+GDTNI YL +NNV IW+EW A + G+LG Sbjct: 61 WFLKGDTNIKYLVDNNVNIWNEWPYEIFKKSNDYQGESLKEFSQKIKEDSSFAQKYGELG 120 Query: 92 PVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQ 151 PVYGKQWR + +DQI+ V+N +KN+P SRR+IVSAWNV ++DKMAL PCHAFFQ Sbjct: 121 PVYGKQWRDF-----FGVDQISQVINDIKNNPTSRRLIVSAWNVAQIDKMALPPCHAFFQ 175 Query: 152 FYVADG-KLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYS 210 FYV D +LS LYQRS D+FLG+PFNIASY+LL+ M+AQ +L+VG+F+ T GD H+YS Sbjct: 176 FYVNDNNELSLHLYQRSGDMFLGVPFNIASYSLLLSMVAQVTNLKVGEFIHTIGDAHIYS 235 Query: 211 NHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 NH+DQ + QL R P LPKLI+ + ++IFD+ FED E+E Y H IKA VA+ Sbjct: 236 NHIDQVNTQLERAPYKLPKLILNKNIKNIFDFTFEDIELENYISHETIKAKVAV 289 >UniRef50_A9NG27 Thymidylate synthase n=12 Tax=cellular organisms RepID=TYSY_ACHLI Length = 288 Score = 361 bits (926), Expect = 2e-98, Method: Composition-based stats. Identities = 154/293 (52%), Positives = 198/293 (67%), Gaps = 34/293 (11%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL 60 MKQYL+L + +++ GT K+DRTGTGT SIFG+QM F+L+DGFPL+TTK+ L+ IIHELL Sbjct: 1 MKQYLDLARHIMENGTLKSDRTGTGTKSIFGYQMFFDLKDGFPLLTTKKTFLKGIIHELL 60 Query: 61 WFLQGDTNIAYLHENNVTIWDEWADEN-----------------------------GDLG 91 WF++GDTNI YL +NNV IW +W +N GDLG Sbjct: 61 WFIKGDTNIKYLVDNNVGIWTDWPYKNYMNSSEYQGESIKEFSDKIRQSDEFAKKWGDLG 120 Query: 92 PVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQ 151 PVYG QWR + +DQI ++N LK +PDSRR+++SAWN E+ +M L PCH Q Sbjct: 121 PVYGSQWRNF-----NGVDQIEYIINTLKTNPDSRRMVLSAWNPAEIGQMMLPPCHTLIQ 175 Query: 152 FYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSN 211 FYV D KLS QLYQRS DVFLG+PFNIASYA+ + M+AQ E+G FV T GD H+Y+N Sbjct: 176 FYVVDNKLSLQLYQRSGDVFLGIPFNIASYAVFLMMVAQVTGFELGSFVHTIGDAHIYTN 235 Query: 212 HMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 H DQ +LQL+R PR LP L I + + D+++EDFE+ GYDP+P IK VA+ Sbjct: 236 HFDQINLQLTRTPRRLPILKINKSITRLEDFKYEDFELVGYDPYPPIKGVVAV 288 >UniRef50_C4Q3X9 Thymidylate synthase n=3 Tax=root RepID=C4Q3X9_SCHMA Length = 577 Score = 358 bits (919), Expect = 1e-97, Method: Composition-based stats. Identities = 132/281 (46%), Positives = 175/281 (62%), Gaps = 21/281 (7%) Query: 4 YLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQD-GFPLVTTKRCHLRSIIHELLWF 62 YL L++ +L G ++ DRT TGT +FG Q+RF+L++ +PL+TTK R I+ ELLWF Sbjct: 296 YLNLLRYILANGVERRDRTDTGTFGVFGPQLRFSLRNHEYPLLTTKTVFFRGIVEELLWF 355 Query: 63 LQGDTNIAYLHENNVTIWDEWAD------------ENGDLGPVYGKQWRA--------WP 102 ++G TN L E NV WD E GDLGPVYG QWR Sbjct: 356 IRGSTNSRELAEKNVHFWDANGSREFLDGLGFTEREEGDLGPVYGFQWRHSGAEYVDCQT 415 Query: 103 TPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQ 162 G+ +DQ+ V+ ++ P RRI++ AWNV +L KMAL PCH QFYVA+ +LSCQ Sbjct: 416 DYTGQGVDQLADVIKLIRERPWDRRIMIVAWNVKDLRKMALPPCHCLVQFYVANDELSCQ 475 Query: 163 LYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSR 222 LYQRS D+ LG+PFNIASYALL M+A L+ G+FV T GD H+YSNH + Q+ R Sbjct: 476 LYQRSGDMGLGVPFNIASYALLTCMIAHVTGLKPGEFVHTIGDAHIYSNHREALLEQVKR 535 Query: 223 EPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263 PRP PKL I R+ ++I D++FEDF++ Y P+P I +A Sbjct: 536 VPRPFPKLEIIREVKNIDDFKFEDFKLIDYKPYPKIPMKMA 576 >UniRef50_Q27828 Thymidylate synthase n=1 Tax=Paramecium tetraurelia RepID=DRTS_PARTE Length = 462 Score = 358 bits (919), Expect = 1e-97, Method: Composition-based stats. Identities = 141/283 (49%), Positives = 189/283 (66%), Gaps = 21/283 (7%) Query: 2 KQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLW 61 QYL+++ K++ EG K+DRTG GT+SIFG MRFNL FPL+TTK+ R ++ ELLW Sbjct: 181 NQYLDMITKIMKEGVSKDDRTGVGTMSIFGQTMRFNLAQSFPLLTTKKVFFRGVVEELLW 240 Query: 62 FLQGDTNIAYLHENNVTIW-----DEWADENG-------DLGPVYGKQWRAW-------- 101 FL+G+TN L + V IW E+ D G DLGPVYG QWR + Sbjct: 241 FLRGNTNGKLLLDKGVKIWEGNGTREYLDTIGLQHRQEHDLGPVYGFQWRHFGAKYKDCQ 300 Query: 102 PTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSC 161 + +DQ+ ++ LKN+PDSRRII+SAWN +L +MAL PCH QF+VA+GKLSC Sbjct: 301 TDYSNQGVDQVKEIIQLLKNNPDSRRIILSAWNPIDLKQMALPPCHVMSQFFVANGKLSC 360 Query: 162 QLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLS 221 +YQRSCD LG+PFNIASYALL +M+A++C+L +G+FV GDTH+YSNH++ Q+ Sbjct: 361 MMYQRSCDFGLGIPFNIASYALLTYMLAKECNLNLGEFVHVLGDTHIYSNHVEALKKQIE 420 Query: 222 REPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 R P P P L IK +S+FDY +EDFE+ GY+ H I+ +A+ Sbjct: 421 RVPYPFPLLKIKGN-KSLFDYTYEDFELVGYNAHDKIEMKMAV 462 >UniRef50_D2CLW7 Dihydrofolate reductase-thymidylate synthase n=75 Tax=Plasmodium RepID=D2CLW7_9APIC Length = 641 Score = 356 bits (915), Expect = 4e-97, Method: Composition-based stats. Identities = 126/281 (44%), Positives = 178/281 (63%), Gaps = 20/281 (7%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62 QYL ++ V+ G +++DRTG G LS FG+ M++NL + FPL+TTK+ +R II ELLWF Sbjct: 360 QYLNIIYDVMMNGNKQDDRTGVGVLSKFGYMMKYNLAEYFPLLTTKKLFVRGIIEELLWF 419 Query: 63 LQGDTNIAYLHENNVTIWDEWADEN------------GDLGPVYGKQWRAWPT------- 103 ++G+TN L NV IW+ DLGP+YG QWR + Sbjct: 420 IRGETNGNILLNKNVRIWEANGTREFLDNRKLFDREVNDLGPIYGFQWRHFGAEYTNMYD 479 Query: 104 -PDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQ 162 + + IDQ+ ++N +KN+P SRRII+ AWNV +LDKMAL PCH QFY+ DGKLSC Sbjct: 480 NYENKGIDQLKNIINLIKNEPTSRRIILCAWNVKDLDKMALPPCHILCQFYIFDGKLSCI 539 Query: 163 LYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSR 222 +YQRSCD+ LG+PFNIASY++ +M+AQ C+L+ +F+ G+ H+Y+NH+D +QL+R Sbjct: 540 MYQRSCDLGLGVPFNIASYSIFTYMLAQVCNLQPAEFIHVLGNAHIYNNHIDSLKIQLNR 599 Query: 223 EPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263 P P P L + + ++I D+ DF IE Y H I +A Sbjct: 600 IPYPFPTLKLNPEIKNIEDFTISDFTIENYVHHDKIAMDMA 640 >UniRef50_Q27783 Thymidylate synthase n=25 Tax=Trypanosomatidae RepID=DRTS_TRYBB Length = 527 Score = 354 bits (908), Expect = 2e-96, Method: Composition-based stats. Identities = 131/284 (46%), Positives = 178/284 (62%), Gaps = 21/284 (7%) Query: 2 KQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQD-GFPLVTTKRCHLRSIIHELL 60 +QYL L+ +++DEG K DRTG GT S+FG QMRF+L++ PL+TTKR R + ELL Sbjct: 244 EQYLNLVGRIIDEGCTKCDRTGVGTRSLFGAQMRFSLRNNRLPLLTTKRVFWRGVCEELL 303 Query: 61 WFLQGDTNIAYLHENNVTIWD-----EWADENG-------DLGPVYGKQWRAWPT----- 103 WFL+G+TN L + + IWD + D G DLGPVYG QWR + Sbjct: 304 WFLRGETNAKLLSDKGIHIWDGNGSRAFLDSRGLTDYDEMDLGPVYGFQWRHFGADYISC 363 Query: 104 ---PDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLS 160 +G+ +DQI ++ L +PD RR+I +AWN L +MAL PCH QFYV++G+LS Sbjct: 364 KVDSEGKGVDQIANIVKSLIENPDDRRMICTAWNPAALPRMALPPCHMMAQFYVSNGELS 423 Query: 161 CQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQL 220 C LYQRSCD+ LG+PFNIASYALL +MA+ L G+ V T GD H+YSNH++ QL Sbjct: 424 CMLYQRSCDMGLGVPFNIASYALLTFLMAKASGLRPGELVHTLGDAHVYSNHVEPCRKQL 483 Query: 221 SREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 R PRP P ++ K+ E + D++ D E+ Y P+P I +A+ Sbjct: 484 KRVPRPFPFIVFKQDKEFLEDFQESDIEVIDYSPYPVISMEMAV 527 >UniRef50_D2W4C0 Predicted protein n=1 Tax=Naegleria gruberi RepID=D2W4C0_NAEGR Length = 535 Score = 349 bits (897), Expect = 4e-95, Method: Composition-based stats. Identities = 126/286 (44%), Positives = 182/286 (63%), Gaps = 24/286 (8%) Query: 3 QYLELMQK-VLDEGTQKNDRTGTGTLSIFGHQMRFNLQDG-FPLVTTKRCHLRSIIHELL 60 QYL+++++ +L + + +RTG GT+S FG+QM+++L++ FPL+TTKR + + EL Sbjct: 250 QYLDIIKELILSDINVREERTGVGTVSKFGYQMKYSLRNNVFPLLTTKRVFWKGVAKELF 309 Query: 61 WFLQGDTNIAYLHENNVTIWD-----EWADENG-------DLGPVYGKQWRAW------- 101 WF+ G TN L E ++ IWD E+ D G DLGPVYG QWR W Sbjct: 310 WFISGSTNAKILSEQDIHIWDGNGSREYLDSLGFENREEMDLGPVYGFQWRHWGSSYENM 369 Query: 102 -PTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVAD--GK 158 + +DQ+ + LKN+P +RRII+SAWNV +L MAL PCH QF+V + Sbjct: 370 HTDYTNKGVDQLKKCIETLKNNPTNRRIILSAWNVSDLPNMALPPCHLMCQFWVDTDTNE 429 Query: 159 LSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHL 218 LSCQ+YQRSCD+ LG+PFNIASYALL +MAQ C+L+ GDF+ T GDTH+Y NH++ Sbjct: 430 LSCQMYQRSCDMGLGVPFNIASYALLTRLMAQVCNLKPGDFIHTLGDTHVYKNHIEPLKK 489 Query: 219 QLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 Q+ R+P+ P L++ +I D++FE ++ Y+PH IK +A+ Sbjct: 490 QIERDPKHFPLLLLDPSITNIDDFKFEHLTLQNYEPHATIKMEMAV 535 >UniRef50_Q27713 Thymidylate synthase n=5 Tax=Plasmodium RepID=DRTS_PLABA Length = 587 Score = 349 bits (895), Expect = 6e-95, Method: Composition-based stats. Identities = 123/281 (43%), Positives = 175/281 (62%), Gaps = 20/281 (7%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62 QYL ++ ++ G +++DRTG G LS FG+ M+FNL + FPL+TTK+ +R II ELLWF Sbjct: 306 QYLNIIYDIIMHGNKQDDRTGVGVLSKFGYMMKFNLNEYFPLLTTKKLFIRGIIEELLWF 365 Query: 63 LQGDTNIAYLHENNVTIWDEWADEN------------GDLGPVYGKQWRAWPT------- 103 ++G+TN L E NV IW+ DLGP+YG QWR + Sbjct: 366 IRGETNGNTLLEKNVRIWEANGTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYTDMHD 425 Query: 104 -PDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQ 162 + +DQ+ ++N +KNDP RRII+ AWNV LD+MAL PCH QFYV DGKLSC Sbjct: 426 NYKDKGVDQLKNIINLIKNDPTCRRIILCAWNVKNLDQMALPPCHILCQFYVFDGKLSCI 485 Query: 163 LYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSR 222 +YQRSCD+ LG+PFNIASY++ +M+AQ C+L+ +F+ G+ H+Y+NH++ +QL+R Sbjct: 486 MYQRSCDLGLGVPFNIASYSIFTYMIAQVCNLQAAEFIHVLGNAHVYNNHIESLKIQLNR 545 Query: 223 EPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263 P P P L + ++I D+ DF ++ Y H I +A Sbjct: 546 TPYPFPTLKLNPDIKNIEDFTISDFTVQNYVHHDKINMDMA 586 >UniRef50_B1C3H3 Thymidylate synthase n=6 Tax=Bacteria RepID=B1C3H3_9FIRM Length = 295 Score = 346 bits (888), Expect = 4e-94, Method: Composition-based stats. Identities = 144/298 (48%), Positives = 191/298 (64%), Gaps = 37/298 (12%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL 60 MKQYLE+ + VL+ G ++DRTGTGT S+FG+Q R++L+DGFPL+TTK+ +R I ELL Sbjct: 1 MKQYLEMCKYVLENGEDRSDRTGTGTRSVFGYQTRYDLRDGFPLMTTKKMFIRPIAEELL 60 Query: 61 WFLQGDTNIAYLHENNVTIWDEWADEN--------------------------------G 88 WF++GDTNI YL + NV IW+EW EN G Sbjct: 61 WFIKGDTNIKYLVDRNVKIWNEWPYENYKKSKDYQGETIEEFIEKIKNLPEDDSFVLKYG 120 Query: 89 DLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHA 148 DLGPVYG QWR + + +DQ+ +++ LKNDP SRR I+ AWN ++D M L PCHA Sbjct: 121 DLGPVYGAQWRNF---NYEGVDQLAKLVDSLKNDPFSRRHIICAWNPAQVDNMTLPPCHA 177 Query: 149 FFQFYVADGK--LSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDT 206 F QFYV+ K LSCQLYQRS D+FLG+PFNIASYAL+V M+A+ C E +FV T GD Sbjct: 178 FLQFYVSADKKYLSCQLYQRSADIFLGVPFNIASYALMVEMLARTCGYEAKEFVHTIGDA 237 Query: 207 HLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 H+Y +H D QL R+P P KL++ + +SIFDY+ ED +IE Y + + V++ Sbjct: 238 HIYKDHFDVVKQQLERKPLPKCKLVLNPEVKSIFDYKIEDIKIEDYQSYGKLVGKVSV 295 >UniRef50_Q67JQ1 Thymidylate synthase n=1 Tax=Symbiobacterium thermophilum RepID=TYSY_SYMTH Length = 283 Score = 345 bits (885), Expect = 9e-94, Method: Composition-based stats. Identities = 126/277 (45%), Positives = 177/277 (63%), Gaps = 16/277 (5%) Query: 3 QYLELMQKVLDE-------GTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSI 55 QYLEL +++L E G +RTG GT+ +FG ++ + ++GFP +TTK+ S+ Sbjct: 6 QYLELCREILAENEQEIAEGRWTPNRTGMGTVGVFGRMLKHDFKEGFPALTTKKLFFNSV 65 Query: 56 IHELLWFLQGDTNIAYLHENNVTIWDEWADENG-DLGPVYGKQWRAWPTPDGRHIDQITT 114 ELLWFL G T++ +LHE IWD+ A NG LGP+YGKQWRAW DGR DQI Sbjct: 66 KAELLWFLAGRTDLEFLHERGCHIWDKDAARNGGKLGPIYGKQWRAWEGADGRTYDQIAW 125 Query: 115 VLNQLKN--------DPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQR 166 V+ Q++ P+SRR++VS WNV +L++MAL PCH FQF+V DG+L ++QR Sbjct: 126 VIQQIREIAADPERPHPNSRRLVVSPWNVADLEEMALPPCHGPFQFHVKDGRLHLAVWQR 185 Query: 167 SCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRP 226 S D+FLG+PFNIASY+LL+HM+AQ L VG + D H+Y N +DQ LQL+REP P Sbjct: 186 SADLFLGVPFNIASYSLLLHMVAQVTGLAVGTYTHYLNDVHIYRNLLDQVRLQLTREPYP 245 Query: 227 LPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263 LP+L + + I + +D ++ Y HP I+ ++ Sbjct: 246 LPRLWLNPEVREIDQFTMDDIQLVDYKHHPPIRGELS 282 >UniRef50_O96650 Thymidylate synthase n=17 Tax=root RepID=TYSY_ASCSU Length = 294 Score = 345 bits (885), Expect = 1e-93, Method: Composition-based stats. Identities = 126/284 (44%), Positives = 178/284 (62%), Gaps = 21/284 (7%) Query: 2 KQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDG-FPLVTTKRCHLRSIIHELL 60 ++YL ++ ++DEG + DRTG GTLS+FG ++L++G PL+TTKR + + ++ ELL Sbjct: 11 RKYLRQIKHIIDEGDKVIDRTGVGTLSLFGLHSTYSLRNGVIPLLTTKRVYWKGVVEELL 70 Query: 61 WFLQGDTNIAYLHENNVTIWDEWADEN------------GDLGPVYGKQWRAWPT----- 103 WF++GDT+ L V IWD GDLGP+YG QWR + Sbjct: 71 WFIKGDTDAKRLSAKGVKIWDANGSREFLDSQGFKDRPEGDLGPIYGFQWRHFGAEYHGT 130 Query: 104 ---PDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLS 160 G+ +DQ+ V+ Q+KN+P+SRRII++AWNV +L +MAL PCH QF V +G+LS Sbjct: 131 DADYKGQGVDQLADVIEQIKNNPNSRRIILNAWNVKDLHQMALPPCHTLAQFAVKNGELS 190 Query: 161 CQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQL 220 CQLYQRS D+ LG+PFN+ASY LL HM+A C L+ G GD H+Y NH+D QL Sbjct: 191 CQLYQRSGDMGLGVPFNLASYGLLTHMIAHVCALKTGFLHHVLGDAHVYLNHIDALKEQL 250 Query: 221 SREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 SR+PRP P + + + +SI D+ E + GY+P IK P+A+ Sbjct: 251 SRDPRPFPTVHFEGRIDSIDDFTAESIILNGYNPMAPIKMPMAV 294 >UniRef50_B6AE97 Thymidylate synthase family protein n=4 Tax=cellular organisms RepID=B6AE97_9CRYT Length = 549 Score = 344 bits (882), Expect = 2e-93, Method: Composition-based stats. Identities = 129/283 (45%), Positives = 177/283 (62%), Gaps = 21/283 (7%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62 QYL+++ VL G + +RTG T SIFG MRF+L++ FPL+TTK LR I EL+WF Sbjct: 267 QYLDMLSNVLQNGHYRENRTGINTYSIFGASMRFDLRESFPLLTTKNVALRIIFEELMWF 326 Query: 63 LQGDTNIAYLHENNVTIW-----DEWADENG-------DLGPVYGKQWRAWPT------- 103 ++GDTN +L + V IW E+ ++ G DLGP+YG QWR + Sbjct: 327 IKGDTNGNHLLDKKVFIWAGNGSKEYLNKVGLGYREENDLGPIYGFQWRHFNAEYKTMHD 386 Query: 104 -PDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYV-ADGKLSC 161 +G+ +DQ+ ++ LK +P RR I+SAWN + MAL PCH QFYV + +LSC Sbjct: 387 NYNGQGVDQLANLIESLKKNPYDRRHILSAWNPSAVKYMALPPCHILSQFYVDNNNRLSC 446 Query: 162 QLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLS 221 LYQRSCD+ LG PFNIASY+LL M+A C E G+F+ GD H+Y NH++Q Q+ Sbjct: 447 SLYQRSCDLGLGCPFNIASYSLLCVMIAHICGYEPGEFIHFIGDVHIYENHVEQLKQQIK 506 Query: 222 REPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 R PRP P+L +KRK + + D+ +ED EI GY PHP I+ +A+ Sbjct: 507 RLPRPFPQLRLKRKVDKVEDFIWEDIEIIGYYPHPTIRMEMAV 549 >UniRef50_Q98Q31 Thymidylate synthase n=2 Tax=root RepID=TYSY_MYCPU Length = 286 Score = 343 bits (881), Expect = 3e-93, Method: Composition-based stats. Identities = 150/293 (51%), Positives = 195/293 (66%), Gaps = 36/293 (12%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL 60 MKQYL+ ++ VL++G K +RT T+S FG+QMRF+L GFPLVTTK+ + +I HELL Sbjct: 1 MKQYLDFLKWVLEKGKHKENRTSVDTISAFGYQMRFDLSKGFPLVTTKKTNFSAIAHELL 60 Query: 61 WFLQGDTNIAYLHENNVTIWDEW-----------------------------ADENGDLG 91 WF++GDTNI YL +N V IW++W A ++G+LG Sbjct: 61 WFIKGDTNIKYLVDNKVNIWNQWPYESYKKSQDFQSESLKEFIQKIKDDNEFAQKHGNLG 120 Query: 92 PVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQ 151 PVYGKQWR + IDQ+ V+ Q+KN+P+SRR+IVS+WN E+D M L PCH FQ Sbjct: 121 PVYGKQWRDF-----LGIDQLKKVIEQIKNNPNSRRLIVSSWNPSEIDTMLLPPCHTLFQ 175 Query: 152 FYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSN 211 FYV D KLSC LYQRS D FLG+PFNIASYALL ++AQ+ +LEVGDFV + GD H+Y N Sbjct: 176 FYVNDNKLSCHLYQRSADAFLGIPFNIASYALLTFLLAQETNLEVGDFVHSIGDAHIYVN 235 Query: 212 HMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 H++Q QL R P+ LPKLIIK ++IF+ FED E+ Y+ P IK VA+ Sbjct: 236 HLEQVKTQLKRNPKELPKLIIKN--KNIFEINFEDIELVDYEFDPIIKGEVAV 286 >UniRef50_Q9UTI7 Probable thymidylate synthase n=17 Tax=cellular organisms RepID=TYSY_SCHPO Length = 625 Score = 339 bits (870), Expect = 5e-92, Method: Composition-based stats. Identities = 127/295 (43%), Positives = 178/295 (60%), Gaps = 32/295 (10%) Query: 2 KQYLELMQKVLDEGTQKNDRTGTGTLSIF-GHQMRFNLQDG-FPLVTTKRCHLRSIIHEL 59 +QYL L++ +L+ G + DRTGTGT S+F Q+RF+L++ PL+TTKR LR ++ EL Sbjct: 331 EQYLNLIRYILENGQSRPDRTGTGTRSVFAPPQLRFSLRNNTLPLLTTKRVFLRGVLEEL 390 Query: 60 LWFLQGDTNIAYLHENNVTIWDEWADEN------------GDLGPVYGKQWRAW------ 101 LWF+ GDTN +L E + IWD GDLGP+YG QWR + Sbjct: 391 LWFIHGDTNANHLSEKGIHIWDGNGSREFLDSRGLTDRKVGDLGPIYGFQWRHFGAQYVD 450 Query: 102 --PTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVAD--- 156 + +DQ+ V++ LK +P RRII+SAWN + +MAL PCH F QFYV++ Sbjct: 451 CDTDYTNKGVDQLAQVISTLKLNPYDRRIILSAWNPLAIPEMALPPCHIFCQFYVSEPCK 510 Query: 157 --GK--LSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNH 212 GK LS +YQRS D+ LG+PFNIASY+LL HM+A C E +FV GD H+Y++H Sbjct: 511 PGGKPQLSSMMYQRSADMGLGVPFNIASYSLLTHMIAHMCGYEAAEFVHVMGDCHIYNDH 570 Query: 213 MDQTHLQLSREPRPLPKLIIKRKPE---SIFDYRFEDFEIEGYDPHPGIKAPVAI 264 ++ QL R P+ PKL KR + SI + +DF +EGY+P+ IK +++ Sbjct: 571 LEALQTQLERVPKAFPKLFFKRDAKDIGSIDSFSVDDFAVEGYNPYGPIKMKMSV 625 >UniRef50_Q0FG99 Thymidylate synthase n=4 Tax=root RepID=Q0FG99_9RHOB Length = 292 Score = 334 bits (858), Expect = 2e-90, Method: Composition-based stats. Identities = 145/292 (49%), Positives = 188/292 (64%), Gaps = 28/292 (9%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL 60 MKQYL+ + ++D G + +DRTG GTLS+FG+Q+RFNLQ+GFP VTTK+ RSI+ ELL Sbjct: 1 MKQYLDALNYIMDNGEEVSDRTGVGTLSVFGYQIRFNLQEGFPAVTTKKLAWRSIVGELL 60 Query: 61 WFLQGDTNIAYLHE-----------NNVTIWDEWADENG------------DLGPVYGKQ 97 WFL+G T+ L E + TIW AD G +LGPVYG Q Sbjct: 61 WFLEGSTDERRLAELTFNKDRTDLVHKKTIWTANADAQGAELGYENNDLIKELGPVYGHQ 120 Query: 98 WRAWPTPDGR---HIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYV 154 WR + D DQI ++N++KN+PDSRR+I+SAWN ++++MAL PCH QF V Sbjct: 121 WRHFDGTDKDISLSTDQIIWLINEIKNNPDSRRMILSAWNPNQINEMALPPCHTMAQFRV 180 Query: 155 ADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMD 214 +GKLSCQLYQRS D+FLG+PFNIASY+LL HM+AQ CDL+VG FVW GGD H+Y NH Sbjct: 181 MNGKLSCQLYQRSADMFLGVPFNIASYSLLTHMLAQLCDLKVGSFVWVGGDCHIYKNHKK 240 Query: 215 QTHLQLSREPRPLPKLIIK--RKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 Q QL R P+ LP L + + + R + ++ YDP IKAP+AI Sbjct: 241 QVLEQLKRTPKSLPNLEMPSFSNLDELLQTRPIGYVLKNYDPMDSIKAPMAI 292 >UniRef50_Q8WYK3 Thymidylate synthase n=4 Tax=Eutheria RepID=Q8WYK3_HUMAN Length = 279 Score = 333 bits (853), Expect = 6e-90, Method: Composition-based stats. Identities = 131/274 (47%), Positives = 167/274 (60%), Gaps = 38/274 (13%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62 QYL +Q +L G +K+DRTGTGTLS+FG Q R++L+D FPL+TTKR + ++ ELLWF Sbjct: 32 QYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWF 91 Query: 63 LQGDTNIAYLHENNVTIWDEWAD------------ENGDLGPVYGKQWRAWPTPDGRHID 110 ++G TN L V IWD E GDLGPVYG QWR + Sbjct: 92 IKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEGDLGPVYGFQWRHFGAE------ 145 Query: 111 QITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDV 170 +++D L MAL PCHA QFYV + +LSCQLYQRS D+ Sbjct: 146 -----YRDMESD---------------LPLMALPPCHALCQFYVVNSELSCQLYQRSGDM 185 Query: 171 FLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKL 230 LG+PFNIASYALL +M+A L+ GDF+ T GD H+Y NH++ +QL REPRP PKL Sbjct: 186 GLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKL 245 Query: 231 IIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 I RK E I D++ EDF+IEGY+PHP IK +A+ Sbjct: 246 RILRKVEKIDDFKAEDFQIEGYNPHPTIKMEMAV 279 >UniRef50_Q76YC2 DTMP synthase n=1 Tax=Aeromonas phage Aeh1 RepID=Q76YC2_9CAUD Length = 277 Score = 328 bits (840), Expect = 2e-88, Method: Composition-based stats. Identities = 117/282 (41%), Positives = 160/282 (56%), Gaps = 23/282 (8%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL 60 MK YL+++ + G + DRTG GT S+ G R ++ DGFP VTTK +++ E L Sbjct: 1 MKAYLDIINYTFENGEDEMDRTGVGTRSVLGQVFRHDMADGFPAVTTKTLAWKAVRGECL 60 Query: 61 WFLQGDTNIAYLHENN-------VTIWDEWAD--------ENGDLGPVYGKQWRAWPTPD 105 WF+ G TN+ L TIWD+ + +G+LGPVYGKQWR + Sbjct: 61 WFMNGFTNVEVLRAMTYGVGSSSKTIWDDNFNHQGVALGYTDGELGPVYGKQWRDF---- 116 Query: 106 GRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQ 165 +DQ+ + ++K +P+ RR IV AWN +LDKMAL PCH F+F V G+L+ YQ Sbjct: 117 -NGVDQLAKAIERIKTNPECRRNIVCAWNPVDLDKMALPPCHVLFRFSVKRGRLNLTWYQ 175 Query: 166 RSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPR 225 RS D FLGLPFNIASY LL+ ++AQ + G DTH+Y NH +Q QL REP Sbjct: 176 RSVDTFLGLPFNIASYGLLLEIVAQITGYKAGILTGMLDDTHIYHNHFEQVQEQLQREPH 235 Query: 226 PLPKLIIKRKPESIFD---YRFEDFEIEGYDPHPGIKAPVAI 264 LP L K + ++ + +D E+E Y H IKAP+A+ Sbjct: 236 KLPTLKFKNRFTTLEEACNLSVDDIELEDYKCHSAIKAPMAV 277 >UniRef50_Q04FR4 Thymidylate synthase n=279 Tax=cellular organisms RepID=TYSY_OENOB Length = 319 Score = 328 bits (840), Expect = 2e-88, Method: Composition-based stats. Identities = 134/314 (42%), Positives = 180/314 (57%), Gaps = 51/314 (16%) Query: 2 KQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLW 61 +QYL L +++L+ G K DRT TGT SIFG QMRF+L +GFPL+T+K+ I ELLW Sbjct: 6 EQYLNLARRILETGASKMDRTKTGTHSIFGAQMRFDLSEGFPLLTSKKVAFGRIKSELLW 65 Query: 62 FLQGDTNIAYLHENNVTIWDEWADEN---------------------------------- 87 FL+GD NI +L +++ IWDEW + Sbjct: 66 FLRGDNNIRFLLQHHNHIWDEWPFKKWVESNEYKGPDMTDFGLRTQKDPIFAEQYKEQKK 125 Query: 88 ----------------GDLGPVYGKQWRAWP-TPDGRHIDQITTVLNQLKNDPDSRRIIV 130 G +G VYGK WR WP D +DQIT ++N++K +P+SRR+I+ Sbjct: 126 IFVDRILNDDEFSKKFGTIGDVYGKLWRHWPDANDDGSVDQITRLINEIKVNPNSRRLIL 185 Query: 131 SAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQ 190 +AW+ L CH QFYV DGK+S Q+YQRS D FLG+PFNIASY+LL+ M+A Sbjct: 186 TAWDPETTPFATLPSCHVMSQFYVVDGKISLQMYQRSADYFLGVPFNIASYSLLLSMVAA 245 Query: 191 QCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIE 250 Q LEVG+F+ T GD H+Y+NH+DQ QLS+ LP L + +SIFDY D ++E Sbjct: 246 QTGLEVGEFIHTIGDAHIYNNHVDQIKEQLSKPTHKLPTLKLNPDVKSIFDYEMSDIKLE 305 Query: 251 GYDPHPGIKAPVAI 264 Y IKAP+A+ Sbjct: 306 NYIHEDVIKAPIAV 319 >UniRef50_P00471 Thymidylate synthase n=17 Tax=T4-like viruses RepID=TYSY_BPT4 Length = 286 Score = 327 bits (838), Expect = 3e-88, Method: Composition-based stats. Identities = 128/291 (43%), Positives = 181/291 (62%), Gaps = 32/291 (10%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL 60 MKQY +L++ + + G + +DRTGTGT+++FG ++R++L GFP VTTK+ ++ I EL+ Sbjct: 1 MKQYQDLIKDIFENGYETDDRTGTGTIALFGSKLRWDLTKGFPAVTTKKLAWKACIAELI 60 Query: 61 WFLQGDTNIAYLHE-------NNVTIWDEWADEN--------GDLGPVYGKQWRAWPTPD 105 WFL G TN+ L T+WDE + G+LGP+YGKQWR + Sbjct: 61 WFLSGSTNVNDLRLIQHDSLIQGKTVWDENYENQAKDLGYHSGELGPIYGKQWRDF---- 116 Query: 106 GRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQ 165 +DQI V++++K P+ RR IVSAWN EL MAL PCH F+QF V +G L Q YQ Sbjct: 117 -GGVDQIIEVIDRIKKLPNDRRQIVSAWNPAELKYMALPPCHMFYQFNVRNGYLDLQWYQ 175 Query: 166 RSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPR 225 RS DVFLGLPFNIASYA LVH++A+ C+L GD +++GG+TH+Y NH++Q L REP+ Sbjct: 176 RSVDVFLGLPFNIASYATLVHIVAKMCNLIPGDLIFSGGNTHIYMNHVEQCKEILRREPK 235 Query: 226 PLPKLII------------KRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 L +L+I K + + + R +DF + Y HP IK +A+ Sbjct: 236 ELCELVISGLPYKFRYLSTKEQLKYVLKLRPKDFVLNNYVSHPPIKGKMAV 286 >UniRef50_Q3J0W9 Thymidylate synthase n=12 Tax=Bacteria RepID=TYSY_RHOS4 Length = 298 Score = 324 bits (832), Expect = 1e-87, Method: Composition-based stats. Identities = 138/293 (47%), Positives = 181/293 (61%), Gaps = 30/293 (10%) Query: 2 KQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDG-FPLVTTKRCHLRSIIHELL 60 +QYL+L+ + L+ G ++ DRTG GTLS+FG +RF+L G P++TTKR + ++ + E+L Sbjct: 6 QQYLDLLAQTLERGDRRVDRTGVGTLSLFGAMLRFDLSGGQVPILTTKRVYWKTAVKEML 65 Query: 61 WFLQGDTNIAYLHENNVTIWDEW----------------------------ADENGDLGP 92 WFL G TNI L + NV IW +W A G+LGP Sbjct: 66 WFLTGGTNIRPLLQENVRIWSDWPLAAYRRESGEEISQAAFEQRVLEDEAFAARWGELGP 125 Query: 93 VYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQF 152 VYGKQWR W PDG DQI ++ L+ +P SRR++ AWNV E+ +MAL PCH +Q+ Sbjct: 126 VYGKQWRRWLGPDGHEHDQIAALIETLRTNPSSRRMLFHAWNVAEVGQMALPPCHMVYQY 185 Query: 153 YVA-DGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSN 211 +V DG+L+ LYQRS D+ LG PFN A L M+AQQ L GD VW GGDTHLY N Sbjct: 186 HVTSDGRLNALLYQRSVDLLLGAPFNFVGAAALQLMIAQQAGLVPGDLVWVGGDTHLYLN 245 Query: 212 HMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 H+DQ Q R PR P++ + R+ +SI DYR EDF +EGYDPHP I A VA+ Sbjct: 246 HLDQAREQTGRAPRDWPRMRLLRRADSIDDYRIEDFAVEGYDPHPAIAAEVAV 298 >UniRef50_A2R2F6 Thymidylate synthase n=20 Tax=Leotiomyceta RepID=A2R2F6_ASPNC Length = 356 Score = 320 bits (820), Expect = 3e-86, Method: Composition-based stats. Identities = 129/318 (40%), Positives = 172/318 (54%), Gaps = 56/318 (17%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIF-GHQMRFNLQDG--------------FPLVTT 47 QYL L++++L EG + DRTGTGT SIF QMRF+L PL+TT Sbjct: 39 QYLNLIRRILSEGEHRPDRTGTGTRSIFAPPQMRFSLSKPSTNTTTGIKEYTPILPLLTT 98 Query: 48 KRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADEN------------GDLGPVYG 95 KR LR+++ ELLWF+ G T+ L E + IWD GDLGPVYG Sbjct: 99 KRVFLRAVLAELLWFISGTTSSLPLSEAGIKIWDGNGSREYLDKVGLSHREVGDLGPVYG 158 Query: 96 KQWRAW--------PTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCH 147 QWR + G+ +DQ+ V+ +LK +P RRII+SAWN ++ MAL PCH Sbjct: 159 FQWRHFGAEYVDAKTDYSGQGVDQLAEVVKKLKENPFDRRIIMSAWNPKDMRIMALPPCH 218 Query: 148 AFFQFYVA------------------DGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMA 189 F QFYV G L C LYQRS D+ LG+PFNIASYALL H++A Sbjct: 219 MFAQFYVRFPDAKRDEEGVVRDGEWGRGHLDCLLYQRSADMGLGVPFNIASYALLTHLLA 278 Query: 190 QQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPES---IFDYRFED 246 D+ G V T GD H+Y +H+D Q+ REP P++ IKR+ + ++ E+ Sbjct: 279 HAVDMVPGTLVHTLGDAHVYLDHVDALKEQIEREPVAFPEVRIKREDRGSGVVDGWKEEE 338 Query: 247 FEIEGYDPHPGIKAPVAI 264 FE+ GY PH IK +++ Sbjct: 339 FEVIGYKPHKAIKMKMSV 356 >UniRef50_Q4PBV6 Thymidylate synthase n=3 Tax=Dikarya RepID=Q4PBV6_USTMA Length = 554 Score = 319 bits (819), Expect = 5e-86, Method: Composition-based stats. Identities = 127/295 (43%), Positives = 181/295 (61%), Gaps = 33/295 (11%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQ--MRFNLQDG-FPLVTTKRCHLRSIIHEL 59 QYLEL+Q+V+ G + DRTGTGTL++F Q +RF+L +G PL+TTKR R ++ EL Sbjct: 260 QYLELVQRVISTGESRPDRTGTGTLALFAPQPSLRFDLTNGTLPLLTTKRVFFRGVLEEL 319 Query: 60 LWFLQGDTNIAYLHENNVTIWDEWADE------------NGDLGPVYGKQWRAW------ 101 LWF+ G T+ L E +V IWD GDLGPVYG QWR + Sbjct: 320 LWFVGGKTDAKLLTEKSVHIWDGNGSRAFLDSRGLSHRREGDLGPVYGFQWRHFGATYKD 379 Query: 102 --PTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVAD--- 156 G+ +DQ+ +V+++++N+P RRI++SAWN +L+ MAL PCH F QF+V++ Sbjct: 380 CDTDYAGQGVDQLASVIDKIRNNPTDRRILLSAWNPADLELMALPPCHMFAQFFVSNLDA 439 Query: 157 -------GKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLY 209 LSCQ+YQRSCD+ LG+PFNIASYALL +M+A+ D E + + GD H+Y Sbjct: 440 YSKGQGKKHLSCQMYQRSCDLGLGVPFNIASYALLTYMIAKVTDCEPKELILAMGDAHVY 499 Query: 210 SNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 +H+ QL R+P P PKL I+R + I D+ F+DF ++GY H I +++ Sbjct: 500 KDHVQPLKAQLERDPLPFPKLKIERDVKDIDDFTFDDFVVQGYKCHGKIDMKMSV 554 >UniRef50_A5KSZ1 Thymidylate synthase n=1 Tax=candidate division TM7 genomosp. GTL1 RepID=A5KSZ1_9BACT Length = 280 Score = 319 bits (817), Expect = 8e-86, Method: Composition-based stats. Identities = 123/273 (45%), Positives = 168/273 (61%), Gaps = 11/273 (4%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62 QYL+LM +L +G K R G +IFG+Q+RF+++ GFPL+TTK+ + ++HEL WF Sbjct: 7 QYLQLMADILKDGRSKPSRGIHGLKAIFGYQIRFDMRQGFPLLTTKKMPFKILLHELFWF 66 Query: 63 LQGDTNIAYLHENNVTIWDEWADEN-GDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKN 121 + G +++ YLHE+ + WD + E DLG VYG QWR W PDG DQ+ + Q+K Sbjct: 67 ISGSSSVDYLHEHKIHYWDGFLHEGSDDLGRVYGVQWRHWLRPDGSQFDQLQWAIEQIKT 126 Query: 122 DPDSRRIIVSAWN----------VGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVF 171 +P+S+ IIVSAWN + M L PCH FQF V GKL QLYQRS DVF Sbjct: 127 NPNSKAIIVSAWNAGELGDKRWNPNDYGDMRLPPCHTMFQFDVTGGKLRMQLYQRSSDVF 186 Query: 172 LGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLI 231 LGLPFNIA YA+L+HM+A DLE + + + G HLY N ++ Q+ R+P PKL Sbjct: 187 LGLPFNIAQYAMLLHMVAYLADLEPRELIISIGSAHLYRNQIEPAKEQVRRKPYRFPKLT 246 Query: 232 IKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 I + I D++ ++F +EGY HP IK + I Sbjct: 247 IAGDVKDIDDFKEKNFSLEGYQSHPHIKTDLVI 279 >UniRef50_Q2G6V6 Thymidylate synthase n=14 Tax=Bacteria RepID=TYSY_NOVAD Length = 314 Score = 315 bits (808), Expect = 8e-85, Method: Composition-based stats. Identities = 140/301 (46%), Positives = 185/301 (61%), Gaps = 39/301 (12%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGF-PLVTTKRCHLRSIIHELLW 61 QYL+LM+++ + G ++ DRTG GT S+FG ++RF+L DG PL+TTKR + ++ E LW Sbjct: 14 QYLDLMRRIWEHGDERVDRTGVGTRSVFGAELRFDLSDGRMPLLTTKRVYWKTATREFLW 73 Query: 62 FLQGDTNIAYLHENNVTIWDEWADEN----------------------------GDLGPV 93 FL G+TNI L V IW +W + GDLGPV Sbjct: 74 FLTGNTNIRPLCAQGVEIWTDWPLDRYRKETGDDISRKDFSARIVADEAFALRWGDLGPV 133 Query: 94 YGKQWRAWP----------TPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMAL 143 YGKQW WP ++Q+ V++ L+++P SRR I+ WNV E+D+MAL Sbjct: 134 YGKQWVDWPVFEPVGDGLFRRREAGVNQVADVVDSLRHNPGSRRHIIEGWNVAEIDRMAL 193 Query: 144 APCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTG 203 PCH +QF+V+ +L+ LYQRSCDV LGLPFN+ ALLV ++AQQCDL+ G+ VW G Sbjct: 194 PPCHKTYQFHVSGNRLNGLLYQRSCDVALGLPFNLWGAALLVRLLAQQCDLQPGELVWMG 253 Query: 204 GDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263 GDTHLY NH D QLSREP P+L I R+P+SIF YR EDFE+ GY P + APVA Sbjct: 254 GDTHLYLNHADLVEAQLSREPEGDPRLAILRRPDSIFGYRIEDFEVTGYAPQGHLSAPVA 313 Query: 264 I 264 + Sbjct: 314 V 314 >UniRef50_Q6QGJ5 Putative thymidylate synthase n=1 Tax=Enterobacteria phage T5 RepID=Q6QGJ5_BPT5 Length = 279 Score = 314 bits (806), Expect = 2e-84, Method: Composition-based stats. Identities = 134/284 (47%), Positives = 182/284 (64%), Gaps = 27/284 (9%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL 60 M+QYL+++ V+ G +NDRTGTGT+SIF +F+L++GFP VTTKR +S++ ELL Sbjct: 1 MQQYLKILTDVILLGEPRNDRTGTGTVSIFDSYAKFDLREGFPAVTTKRLAWKSVVGELL 60 Query: 61 WFLQGDTNIAYLH-------ENNVTIWDEWADEN--------GDLGPVYGKQWRAWPTPD 105 WFL G TN+ L E TIW ++ G+LGPVYGKQWR + Sbjct: 61 WFLSGSTNLHDLRVFTFGRDEGQWTIWTPNYEDQAISMGYDKGNLGPVYGKQWRNF---- 116 Query: 106 GRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVA-DGKLSCQLY 164 DQI ++ LKN+P RR +VSAWNV ELDKMAL PCH FQ YV+ DG L + Sbjct: 117 -GGRDQILELIEGLKNNPHGRRHLVSAWNVAELDKMALPPCHYGFQCYVSNDGYLDLKWT 175 Query: 165 QRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREP 224 QRS D FLGLPFNIASYALL H++A+ L+ +++GGDTH+Y++HM+Q Q+ R+P Sbjct: 176 QRSVDCFLGLPFNIASYALLTHILAKLTGLKPRYLIFSGGDTHIYNDHMEQVEEQVKRKP 235 Query: 225 RPLPKLIIKRKPESIFDYRFED-----FEIEGYDPHPGIKAPVA 263 RPLP L++ + ++D + F +EGYDPHP +KA ++ Sbjct: 236 RPLPTLVM-PEFVDLYDLLENNTAAWSFHLEGYDPHPALKAKMS 278 >UniRef50_D1BNV6 Thymidylate synthase n=4 Tax=Veillonellaceae RepID=D1BNV6_VEIPT Length = 263 Score = 309 bits (793), Expect = 4e-83, Method: Composition-based stats. Identities = 101/265 (38%), Positives = 151/265 (56%), Gaps = 11/265 (4%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62 QYL +++ +LD G +RTG T + M+F+LQ+ FP++TTK ++ + ELLW Sbjct: 7 QYLGIIENILDHGIYGQNRTGIATYKLPQQIMQFDLQEEFPILTTKFVAFKTAVKELLWI 66 Query: 63 LQ-GDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKN 121 Q ++ L E NV +WDEW E+G +G YG Q + Q+ ++ +K Sbjct: 67 WQMQSNDVRKLQEMNVHVWDEWMREDGTIGKAYGYQIAKYK--------QLDKLIKTIKE 118 Query: 122 DPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASY 181 DPDSRR+IV+ WN+ +LD MAL PC + V DG L+C L QRS D+ LG+PFN A Y Sbjct: 119 DPDSRRMIVTLWNIEDLDDMALQPCAYETLWDVGDGYLNCMLIQRSGDMGLGVPFNTAQY 178 Query: 182 ALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSR--EPRPLPKLIIKRKPESI 239 A L M+AQ L+ G F + H+Y NH+D QL+R + P PK+I+ + + Sbjct: 179 AALQCMIAQVTGLKPGKFTHVINNAHIYENHVDALREQLARRNQALPAPKIIVNPEVKDF 238 Query: 240 FDYRFEDFEIEGYDPHPGIKAPVAI 264 +D+ ED ++GY+ + VA+ Sbjct: 239 YDFTPEDITLDGYEHLGKLSMTVAV 263 >UniRef50_D2XB64 Bifunctional dihydrofolate reductase-thymidylate synthase n=1 Tax=Marseillevirus RepID=D2XB64_9VIRU Length = 444 Score = 309 bits (793), Expect = 4e-83, Method: Composition-based stats. Identities = 113/280 (40%), Positives = 162/280 (57%), Gaps = 20/280 (7%) Query: 4 YLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRF-NLQDGFPLVTTKRCHLRSIIHELLWF 62 YL L+ +VL G ++ DRTGTGT S+FG + F N+ + FPL+T KR I+ ELLWF Sbjct: 164 YLSLLSEVLYSGEKRKDRTGTGTRSLFGRHLLFENISEKFPLITVKRMAWGCILSELLWF 223 Query: 63 LQGDTNIAYLHENNVTIWDEWADE-----------NGDLGPVYGKQWRAW--------PT 103 L G T+ L N IW + + GD GP+YG QWR W Sbjct: 224 LSGSTDSKMLELQNNNIWKKNSSRKFLDGRGLSYREGDCGPIYGFQWRHWGAKYVDCDTD 283 Query: 104 PDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQL 163 G+ DQI +++++++N+ SRR+++SAWNV +LDKM L PCH+F QFYV + C L Sbjct: 284 YRGQGEDQILSIISEIQNNATSRRLVLSAWNVSDLDKMCLPPCHSFSQFYVRGDFVDCHL 343 Query: 164 YQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSRE 223 YQRS D+ LG+PFNIASYA L+ ++A+ + G+ + GD H+Y H+D L R Sbjct: 344 YQRSADLALGVPFNIASYACLLSIIAEASGKKAGNLTMSFGDVHIYETHIDNAQKMLERL 403 Query: 224 PRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263 P PKL +K ++F + DFE++GY ++ +A Sbjct: 404 PHKTPKLKVKISDNTLFCLKKGDFELDGYSCCGALQFDMA 443 >UniRef50_A3QU09 Thymidylate synthase n=1 Tax=Oryctes rhinoceros virus RepID=A3QU09_9VIRU Length = 321 Score = 306 bits (784), Expect = 5e-82, Method: Composition-based stats. Identities = 121/293 (41%), Positives = 170/293 (58%), Gaps = 31/293 (10%) Query: 2 KQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDG-FPLVTTKRCHLRSIIHELL 60 + YL L++ VL + +RTG S FGHQ+RF+L++G PL+TTK ++I+ EL Sbjct: 30 RNYLSLVRTVLKAPSS-PNRTGIDARSSFGHQLRFDLRNGVLPLLTTKPMPFKTILRELF 88 Query: 61 WFLQGDTNIAYLHENNVTIW-----DEWADENGDL--------GPVYGKQWRAW------ 101 WFL+G+TN L NV IW E+ D G GP+YG QWR + Sbjct: 89 WFLRGETNQKILERQNVHIWKGNSSREYLDSRGLYDYTEYESLGPIYGFQWRHFGASYVD 148 Query: 102 --PTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYV--ADG 157 + +DQ+ V+ +K DP SRRII+SAWN +LDKMAL PCH QF+V +G Sbjct: 149 CNTDYTNKGVDQLQQVIRTIKEDPTSRRIIMSAWNPVDLDKMALPPCHILVQFHVNTVNG 208 Query: 158 KLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTH 217 +LS QLYQRS D+ LG+PFNIASY++LVH++A+ C L+ G F+ + GD H+Y NH+ Sbjct: 209 ELSAQLYQRSADLMLGVPFNIASYSILVHLIAKICGLKPGYFIHSLGDVHIYENHVSGAK 268 Query: 218 LQLSREPRPLPKLIIKRKPES-----IFDYRFEDFEIEGYDPHP-GIKAPVAI 264 QL+REP+ P L I P + + F++ Y +P IK +A+ Sbjct: 269 EQLTREPQRQPYLNIDIDPTLDLDSILEQLSCDQFKLVNYKYNPNPIKLEMAV 321 >UniRef50_Q65J44 Thymidylate synthase n=9 Tax=root RepID=TYSY_BACLD Length = 279 Score = 303 bits (777), Expect = 4e-81, Method: Composition-based stats. Identities = 98/275 (35%), Positives = 158/275 (57%), Gaps = 13/275 (4%) Query: 2 KQYLELMQKVLDEGTQKN----------DRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCH 51 +QY ++QK+++ G D T TLSI +MRF+ + P++TTK+ Sbjct: 6 QQYNAIIQKIIESGISDEEYQVRTKWDSDGTPAHTLSIMSEKMRFDNSE-VPILTTKKVA 64 Query: 52 LRSIIHELLWFLQ-GDTNIAYLHENNVTIWDEWADENGDLGPVYGKQW-RAWPTPDGRHI 109 ++ I ELLW Q ++ L++ V IWD+W E+G +G YG Q + T +G+ + Sbjct: 65 WKTAIKELLWIWQLKSNDVQVLNDMGVHIWDQWRLEDGTIGAAYGYQLGKKNRTVNGQKV 124 Query: 110 DQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCD 169 DQ+ +L+QLK++P SRR + WN +LD MAL PC Q+YV +GKLS ++ RS D Sbjct: 125 DQVDYLLHQLKHNPSSRRHLTMLWNPDDLDGMALTPCVYETQWYVKEGKLSLEVRARSND 184 Query: 170 VFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPK 229 + LG PFN+ Y +L M+AQ E+G++++ GD H+Y+ H+D ++Q+ RE PK Sbjct: 185 MALGNPFNVFQYNVLQRMIAQVLGYELGEYIFNIGDCHIYTRHIDNLNIQMKREQYEAPK 244 Query: 230 LIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 L I ++ +D+ +DF++ Y + VA+ Sbjct: 245 LWINPDIKNFYDFTIDDFKLIDYKHGDKLTFEVAV 279 >UniRef50_A6M378 Thymidylate synthase n=8 Tax=Clostridium RepID=TYSY_CLOB8 Length = 263 Score = 302 bits (773), Expect = 1e-80, Method: Composition-based stats. Identities = 97/265 (36%), Positives = 148/265 (55%), Gaps = 11/265 (4%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62 +YL + +L+ G N+RTG T + M+FNL+ FP++TTK ++ + ELLW Sbjct: 7 KYLAIANDILENGYFDNNRTGVKTYKLPHQIMQFNLEKEFPILTTKFVAFKTAVKELLWI 66 Query: 63 LQGDTN-IAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKN 121 + +N + L NV IWDEW E+G +G YG + + DQI +++ LKN Sbjct: 67 FKDQSNSVKELQSQNVKIWDEWMMEDGTIGTSYGWIVKKF--------DQIDKLIDALKN 118 Query: 122 DPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASY 181 +P RR++++ W + LD L PC + V DGKL+C L QRS D LG+PFN + Y Sbjct: 119 NPQDRRMMINLWQIPYLDSAPLYPCCFLTMWDVTDGKLNCMLVQRSGDWGLGVPFNTSQY 178 Query: 182 ALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSR--EPRPLPKLIIKRKPESI 239 A+LVH++AQ L+ G F + H+Y N +D LQL+R + PKL I + + Sbjct: 179 AVLVHLLAQVTGLKPGLFTHVINNAHIYENQVDGLKLQLTRKNDAYNAPKLWINPEITNF 238 Query: 240 FDYRFEDFEIEGYDPHPGIKAPVAI 264 +D+ +D ++E Y H IK V++ Sbjct: 239 YDFTPDDIKLEDYKHHESIKMDVSV 263 >UniRef50_B2YFY9 Thymidylate synthase n=1 Tax=Musca domestica salivary gland hypertrophy virus RepID=B2YFY9_9VIRU Length = 294 Score = 292 bits (749), Expect = 5e-78, Method: Composition-based stats. Identities = 107/284 (37%), Positives = 169/284 (59%), Gaps = 24/284 (8%) Query: 4 YLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFP-LVTTKRCHLRSIIHELLWF 62 YL L+++VL +GT K++RTG T IFG Q+R++L+D ++TTK+ RS + ELLWF Sbjct: 10 YLTLVRRVLRDGTLKSNRTGVDTKYIFGDQLRYDLRDNRIAMLTTKKVFFRSALEELLWF 69 Query: 63 LQGDTNIAYLHENNVTIWDEWAD------------ENGDLGPVYGKQWRAW--------P 102 L+GDTN A L V IW + E+ LGP+YG QWR + Sbjct: 70 LRGDTNQANLAAKGVNIWRGNSTREYLDSRKLPYPEHESLGPIYGFQWRHFGARYIDCHT 129 Query: 103 TPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVAD--GKLS 160 G+ +DQ+ ++Q++ +P SRR+I++AWN +LDKM L PCH QF V + G+LS Sbjct: 130 DYTGQGVDQLAQCMHQIQYEPSSRRMIMTAWNPNDLDKMVLPPCHMSIQFSVNEKLGELS 189 Query: 161 CQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQL 220 + QRS D+ LG+PFN+ SY+L++H++A + L+ G+ V + GD H+Y H+ Q+ Sbjct: 190 GHMTQRSADLMLGVPFNLVSYSLMLHILAHKFGLKAGELVTSYGDLHIYVPHIKNAMRQV 249 Query: 221 SREPRPLPKLIIK-RKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263 SR P P++ +K + + + + +DF ++ Y H ++ +A Sbjct: 250 SRLPYASPQIELKFGRDKRVEELTVDDFAVKNYRHHSQLEYEMA 293 >UniRef50_Q88CN9 Thymidylate synthase n=74 Tax=Proteobacteria RepID=TYSY_PSEPK Length = 323 Score = 290 bits (742), Expect = 3e-77, Method: Composition-based stats. Identities = 113/323 (34%), Positives = 162/323 (50%), Gaps = 59/323 (18%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL 60 MKQYL+L++ V+D GT + +RTG T+S+ G +RF+LQ GFP +TT++ +S I E++ Sbjct: 1 MKQYLDLVRDVIDNGTLQGNRTGIRTISLPGAMLRFDLQKGFPAITTRKLAFKSAIGEMV 60 Query: 61 WFLQGDTNIAYLHENNVTIWDEWADEN------------GDLGPVYGKQWRAWPTPD--- 105 FL+G N E +WD+ A+EN DLG +YG QWR WP Sbjct: 61 GFLRGVKNAGEFRELGCKVWDQNANENAQWLANPFRQGHDDLGEIYGVQWRQWPGYKRIP 120 Query: 106 -------------------------------GRHIDQITTVLNQLKNDPDSRRIIVSAWN 134 + IDQ+ L+ + NDP SRRI+ WN Sbjct: 121 LSNPAAIEMAEQAGFRRIAQDEEDGVAFVILYKAIDQVRQCLDTIANDPGSRRILFHGWN 180 Query: 135 VGELDKMALAPCHAFFQFY--VADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQC 192 +LD+MAL PCH +QF+ V ++S LY RS D+ LG PFN+ A L+ + + Sbjct: 181 CAQLDEMALPPCHLLYQFHPNVETREISLTLYIRSNDLGLGTPFNLTEGAALLSLFGRLT 240 Query: 193 DLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKR-----------KPESIFD 241 F + GD H+Y NH+D + QL REP PKL+I +PE + Sbjct: 241 GYTPRWFTYFIGDAHVYENHLDMLNEQLKREPLEAPKLVISDRVPAFAETGKYEPEWLEK 300 Query: 242 YRFEDFEIEGYDPHPGIKAPVAI 264 DF +EGY+ H + AP+A+ Sbjct: 301 IEPSDFWLEGYEHHAPMTAPMAV 323 >UniRef50_A9UZA9 Thymidylate synthase n=1 Tax=Monosiga brevicollis RepID=A9UZA9_MONBE Length = 398 Score = 284 bits (726), Expect = 3e-75, Method: Composition-based stats. Identities = 111/244 (45%), Positives = 138/244 (56%), Gaps = 45/244 (18%) Query: 66 DTNIAYLHENNVTIWDEWAD------------ENGDLGPVYGKQWRAW--------PTPD 105 +TN L +V IWD E GDLGPVYG QWR + Sbjct: 33 NTNANDLAARDVHIWDANGSKDFLEKQGLGHREEGDLGPVYGFQWRHFGAEYKDMHTDYS 92 Query: 106 GRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQ 165 G+ +DQ+ V+ Q+K +PDSRRII+SAWN ++ KMAL PCH QFYV DG+LSCQLYQ Sbjct: 93 GQGVDQLAEVIEQIKTNPDSRRIIMSAWNPLDIPKMALPPCHTMCQFYVCDGELSCQLYQ 152 Query: 166 RSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPR 225 RS D+ LG+PFNIASYALL +M+AQ L+ GDFV T GD H+Y NH+D QL REPR Sbjct: 153 RSADMGLGVPFNIASYALLTYMIAQVTGLKPGDFVHTIGDAHVYLNHVDALEEQLKREPR 212 Query: 226 PLPKLIIKRKPES-------------------------IFDYRFEDFEIEGYDPHPGIKA 260 P P L KR E I D++FEDF+++GY PH I Sbjct: 213 PFPTLSFKRDIEEYVHAFGQHVTNPLEHRPTAALLSLGIDDFKFEDFDLQGYKPHNRIAM 272 Query: 261 PVAI 264 +A+ Sbjct: 273 DMAM 276 >UniRef50_B6FSV1 Putative uncharacterized protein n=1 Tax=Clostridium nexile DSM 1787 RepID=B6FSV1_9CLOT Length = 282 Score = 282 bits (723), Expect = 6e-75, Method: Composition-based stats. Identities = 88/279 (31%), Positives = 142/279 (50%), Gaps = 18/279 (6%) Query: 2 KQYLELMQKVLDEGTQKN---------DRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHL 52 K ++++ + ++D G D + TL F R++L FP +T +R + Sbjct: 6 KVFIDMCRDIIDNGVSTEGEKVRPKWEDGSFAYTLKKFCVVNRYDLSKEFPALTLRRTGI 65 Query: 53 RSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQI 112 +S + ELLW Q +N +H+ IWD WADE+G +G YG Q +DQ+ Sbjct: 66 KSCVDELLWIWQRKSN--NVHDLKPHIWDSWADEDGSIGKAYGYQMSVKHQYKEGMMDQV 123 Query: 113 TTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGK------LSCQLYQR 166 V+ LKN+P SRRI+ + + +L +M L PC F V L+ L QR Sbjct: 124 DRVIYDLKNNPYSRRIMTNIYVHQDLHEMNLYPCAYSMTFNVTKKNDSDKLVLNGILNQR 183 Query: 167 SCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRP 226 S DV +N+ YA+L+HM+AQ CD++VG+FV D H+Y H+ +SREP P Sbjct: 184 SQDVLAANNWNVCQYAVLMHMLAQVCDMQVGEFVHVIADAHIYDRHIPLVEELISREPLP 243 Query: 227 LPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIK-APVAI 264 P + + ++ +++ +D ++ Y+ IK P+A+ Sbjct: 244 APTFWLNPEVKNFYEFTPDDVRLDNYETGSQIKNIPIAV 282 >UniRef50_Q5UQG3 Thymidylate synthase n=1 Tax=Acanthamoeba polyphaga mimivirus RepID=DRTS_MIMIV Length = 563 Score = 282 bits (721), Expect = 9e-75, Method: Composition-based stats. Identities = 108/292 (36%), Positives = 165/292 (56%), Gaps = 34/292 (11%) Query: 2 KQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLW 61 QY+EL++ ++++G K R T SIFG+Q++++L G+P+ T KR + ++I EL+W Sbjct: 273 NQYIELVKTIMEKGIVKQTRNSI-TKSIFGYQLKYDLSKGYPIQTIKRSYPKAIFEELMW 331 Query: 62 FLQGDTNIAYLHENNVTIWDEWAD-----------ENGDLGPVYGKQWRAW--------P 102 ++G T+++ L + V +WD+ + E GD+GP YG Q R W Sbjct: 332 MIRGQTDVSILQKKGVHVWDKNSSKDFLSKYNLPYEEGDIGPGYGFQMRYWGAEYTDCKT 391 Query: 103 TPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYV-------- 154 + G+ IDQ+ + ++N+P RRI+++ WN +LDKMALAPCH + F V Sbjct: 392 SYQGQGIDQLNKCIESIQNNPHDRRIMINLWNCSDLDKMALAPCHFCYMFGVDLYEVPTT 451 Query: 155 --ADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNH 212 G+L+C L QRS DV LG +N + ALL +++A CDL+ G V + D H+Y +H Sbjct: 452 SGKKGRLNCHLVQRSWDVLLG--WNTTTAALLTYLIANHCDLDPGILVHSISDAHIYQSH 509 Query: 213 MD--QTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPV 262 +D L R+ R P L+I+ K E I DY F+D IE Y P P I A + Sbjct: 510 IDSGAISQLLQRKCRKFPNLVIRNKKEKIDDYEFDDLIIENYYPCPSISAEM 561 >UniRef50_A8RRN6 Thymidylate synthase n=16 Tax=Bacteria RepID=A8RRN6_9CLOT Length = 287 Score = 281 bits (720), Expect = 1e-74, Method: Composition-based stats. Identities = 90/271 (33%), Positives = 135/271 (49%), Gaps = 12/271 (4%) Query: 4 YLELMQKVLDEGTQK---------NDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRS 54 +++ +L+ G D T T+ FG R++L FP++T +R +S Sbjct: 19 FIQNCNDILEHGVWDTDYDVRPVWEDGTPAHTIKRFGIVNRYDLTREFPVITLRRTAFKS 78 Query: 55 IIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITT 114 + ELLW Q +N +H+ N IWD WADENG +G YG Q DQ+ Sbjct: 79 AVDELLWIWQKKSN--NIHDLNSHIWDSWADENGSIGKAYGYQLGVKHHYKEGDFDQVDR 136 Query: 115 VLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGL 174 +L LK++P SRRI+ + +N +L +M L PC F V+ L+ L QRS D+ Sbjct: 137 ILYDLKHNPLSRRIMSNIYNHHDLCEMNLYPCAYSMTFNVSGNTLNGILNQRSQDMLTAN 196 Query: 175 PFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKR 234 +N+ YA+L+HM+AQ L+ G+ V D H+Y H+ L REP P P L + Sbjct: 197 SWNVCQYAVLLHMLAQVSGLKPGELVHVIADAHIYDRHIPMVEELLKREPYPGPTLSMDT 256 Query: 235 KPESIFDYRFEDFEIEGYDPHP-GIKAPVAI 264 ++ + + + F +E Y H K PVAI Sbjct: 257 SIQNFYQFTTDSFRLEHYQYHTFSGKIPVAI 287 >UniRef50_Q6WIC0 DTMP (Thymidylate) synthase n=1 Tax=Vibrio phage KVP40 RepID=Q6WIC0_BPKV4 Length = 300 Score = 277 bits (708), Expect = 3e-73, Method: Composition-based stats. Identities = 115/300 (38%), Positives = 167/300 (55%), Gaps = 38/300 (12%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL 60 MK YL+L ++L+EG +RTGT T+S+ ++R++L GFPL+TTK+ ++I ELL Sbjct: 2 MKNYLQLCTEILNEGDFLENRTGTNTVSVISRELRWDLSKGFPLLTTKKMATKAIFGELL 61 Query: 61 WFLQGDTNIAYLHEN------NVTIWDEWADE-------------NGDLGPVYGKQWR-- 99 WFL G I+ L + + IW + DE DLG VYGK WR Sbjct: 62 WFLSGSGLISDLRKYTELSDEDFCIWQQNLDELNERAKKAGIVRNEDDLGYVYGKVWRKR 121 Query: 100 -----AWPTPDGRHIDQITTVLNQLKNDPDS---RRIIVSAWNVGELDKM-----ALAPC 146 + I Q+ + +K DP RR+IV AW+ + AL PC Sbjct: 122 LSVTADKEVTEFDQIHQLLCDIAAVKEDPTQSAQRRMIVEAWDPYFHTESNSVDVALPPC 181 Query: 147 HAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDT 206 H FQ +V +GK+S + QRS D FLGLPFNIASYALLVH++AQ L+VG+ +++GGD Sbjct: 182 HYGFQVFVRNGKISLKWNQRSVDTFLGLPFNIASYALLVHILAQLTGLKVGELIFSGGDV 241 Query: 207 HLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDY---RFEDFEIEGYDPHPGIKAPVA 263 H+Y +H+ Q QL R PR LP++ + + +++ R DF + YDP+P +K ++ Sbjct: 242 HIYEDHIVQVLKQLRRTPRELPQIQL-PEFDTLSQLLTKRASDFVVYDYDPYPALKGKMS 300 >UniRef50_C4Z7Z1 Thymidylate synthase n=19 Tax=Bacteria RepID=C4Z7Z1_EUBR3 Length = 282 Score = 275 bits (705), Expect = 7e-73, Method: Composition-based stats. Identities = 87/279 (31%), Positives = 135/279 (48%), Gaps = 18/279 (6%) Query: 2 KQYLELMQKVLDEGTQKN---------DRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHL 52 K ++ + Q +L+ GT D T T+ FG R++L FP +T ++ ++ Sbjct: 6 KVFVAMCQDILENGTSTEGELVRPHWEDGTSAYTIKKFGVVNRYDLSKEFPAITLRKTYI 65 Query: 53 RSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQI 112 +S ELLW Q +N +H+ +WDEWADE+G +G YG Q +DQ+ Sbjct: 66 KSATDELLWIWQKKSN--NIHDLKSHVWDEWADEDGSIGKAYGYQLGVKHQYKEGMMDQV 123 Query: 113 TTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGK------LSCQLYQR 166 V+ LK+ P SRRI+ + + +L +M L PC F V K L+ L QR Sbjct: 124 DRVIYDLKHTPFSRRILTNIYVHQDLHEMNLYPCAYSMTFNVTQKKGDDRLTLNGILNQR 183 Query: 167 SCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRP 226 S DV +N+ YA+L+HM+AQ CD+ VG+ V D H+Y H+ + R Sbjct: 184 SQDVLAANNWNVCQYAVLMHMLAQVCDMRVGELVHVIADAHIYDRHVPIVKELIERPQYD 243 Query: 227 LPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIK-APVAI 264 PK + + + + +D +I Y IK P+A+ Sbjct: 244 APKFWLNPDIKDFYQFTTDDIKITDYVTGEQIKDIPIAV 282 >UniRef50_UPI0001925B1E PREDICTED: similar to thymidylate synthase, partial n=1 Tax=Hydra magnipapillata RepID=UPI0001925B1E Length = 197 Score = 275 bits (705), Expect = 7e-73, Method: Composition-based stats. Identities = 106/241 (43%), Positives = 144/241 (59%), Gaps = 44/241 (18%) Query: 24 TGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEW 83 TGTLSIFG QMRFNL++ FPL+TTKR + ++ ELLWF+ G T+ L + V IW Sbjct: 1 TGTLSIFGGQMRFNLRESFPLLTTKRVFWKGVVEELLWFISGSTDGNILAQKGVQIW--- 57 Query: 84 ADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMAL 143 + + R + N + MAL Sbjct: 58 --------------------------------------NSNGTREFLDKCN---IPLMAL 76 Query: 144 APCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTG 203 PCH+F QFYVA+G+LSCQ+YQRSCD+ LG+PFNIASY+LL +++A C+L+ GDF+ T Sbjct: 77 PPCHSFCQFYVANGELSCQMYQRSCDMGLGIPFNIASYSLLTYIIAHVCNLKPGDFIHTL 136 Query: 204 GDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263 GD H+Y+NH+ Q+ R PRP PKL IKRK E+I D++ +DFE+ GY+PH IK +A Sbjct: 137 GDAHVYNNHVSALKEQIGRSPRPFPKLNIKRKVENIDDFKSDDFELIGYNPHQKIKMAMA 196 Query: 264 I 264 + Sbjct: 197 V 197 >UniRef50_D2RRK7 Thymidylate synthase n=9 Tax=cellular organisms RepID=D2RRK7_9EURY Length = 338 Score = 270 bits (692), Expect = 2e-71, Method: Composition-based stats. Identities = 116/340 (34%), Positives = 160/340 (47%), Gaps = 80/340 (23%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRC---HLRSIIH 57 M+QYLEL+ VL EGT K +RTG T+S F +LQDG+PL+TTK+ S++H Sbjct: 1 MRQYLELVDTVLSEGTYKPNRTGVDTISSFSEHYEVDLQDGYPLLTTKQMDGYRWNSMLH 60 Query: 58 ELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDG----------- 106 E+ W+L G+ +I L E IWD WAD+ G L YG+ WR +P P+ Sbjct: 61 EVCWYLSGEEHIRDLREET-KIWDAWADDEGRLDTAYGRFWRRFPIPEDDAQLEGESWPD 119 Query: 107 -------------RHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFY 153 R DQ+ V++ L + P+SRR++V+AW+ L PCH F F Sbjct: 120 ETHQWVTEEADGRRTFDQLQYVIDTLSDSPNSRRLVVNAWHPANAAVSTLPPCHYSFVFN 179 Query: 154 VADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYS--- 210 +L+C L QRS D LG+PFNIA+YALL ++AQQ + G F T DTH+Y Sbjct: 180 AQGDRLNCHLTQRSGDTALGIPFNIAAYALLTKVIAQQTGFKPGTFAHTVVDTHVYCGRG 239 Query: 211 -----------------------------------------------NHMDQTHLQLSRE 223 +H+ QLSRE Sbjct: 240 DRGEWYADNLETLQSRLNDVEDREDYLEVKSWLESAAPDEAEGDERLDHVPGLLEQLSRE 299 Query: 224 PRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263 P P L + SI + +ED E++ Y+ H GI+ VA Sbjct: 300 PLERPTLEVADV--SIDELAYEDVELKNYESHEGIEFAVA 337 >UniRef50_A8H1B4 Thymidylate synthase n=132 Tax=root RepID=TYSY_SHEPA Length = 283 Score = 269 bits (688), Expect = 7e-71, Method: Composition-based stats. Identities = 96/283 (33%), Positives = 143/283 (50%), Gaps = 19/283 (6%) Query: 1 MKQYLELMQKVLDEGTQ-KNDRTGTGTLSIFGHQMRFNLQD-GFPLVTTKRCHLRSIIHE 58 MKQYL+L Q+++DEGT +N RTG L++ + +++ FPL+TT++ ++ I E Sbjct: 1 MKQYLDLCQRLIDEGTWVENSRTGKRCLTVINADLVYHVDKNEFPLITTRKSFYKAAIAE 60 Query: 59 LLWFLQGDTNIAYLHENNVTIWDEWADEN------------GDLGPVYGKQWRAWPTPDG 106 LL +++G N A W+ A++N D+G VYG Q RAW PDG Sbjct: 61 LLGYIRGYDNAADFRAIGCNTWNANANDNQAWLDNPHRKGIDDMGRVYGVQGRAWSKPDG 120 Query: 107 RHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQR 166 IDQ+ +++ L D R I+S +N GE L PC F + L +QR Sbjct: 121 GCIDQLRKIVDDLSKGIDDRGEILSFYNPGEFHMGCLRPCMHTHNFSLVGDTLHLTSFQR 180 Query: 167 SCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHL-QLSREPR 225 SCDV LGL FN L+ +MAQ + G + H+Y + ++ QL REP Sbjct: 181 SCDVPLGLNFNQVQVFTLLALMAQITGHKPGTAFHKIVNAHIYEDQLELMQEVQLKREPF 240 Query: 226 PLPKLIIKRKPESIFDYR----FEDFEIEGYDPHPGIKAPVAI 264 PKL+I +S+ D +DFE+ GY+ H I P ++ Sbjct: 241 TSPKLVINPNIKSLEDLETWVSIDDFEVTGYEHHEAISYPFSV 283 >UniRef50_Q8WYK4 Thymidylate synthase n=7 Tax=Fungi/Metazoa group RepID=Q8WYK4_HUMAN Length = 230 Score = 268 bits (686), Expect = 1e-70, Method: Composition-based stats. Identities = 94/174 (54%), Positives = 123/174 (70%), Gaps = 1/174 (0%) Query: 92 PVYGKQWR-AWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFF 150 V+G Q R + G+ +DQ+ V++ +K +PD RRII+ AWN +L MAL PCHA Sbjct: 57 SVFGMQARYSLRDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALC 116 Query: 151 QFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYS 210 QFYV + +LSCQLYQRS D+ LG+PFNIASYALL +M+A L+ GDF+ T GD H+Y Sbjct: 117 QFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYL 176 Query: 211 NHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 NH++ +QL REPRP PKL I RK E I D++ EDF+IEGY+PHP IK +A+ Sbjct: 177 NHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPHPTIKMEMAV 230 Score = 57.6 bits (138), Expect = 4e-07, Method: Composition-based stats. Identities = 22/38 (57%), Positives = 30/38 (78%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQD 40 QYL +Q +L G +K+DRTGTGTLS+FG Q R++L+D Sbjct: 32 QYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRD 69 >UniRef50_B9CJY5 Thymidylate synthase n=10 Tax=Bacteria RepID=B9CJY5_9ACTN Length = 282 Score = 266 bits (680), Expect = 7e-70, Method: Composition-based stats. Identities = 81/277 (29%), Positives = 133/277 (48%), Gaps = 18/277 (6%) Query: 4 YLELMQKVLDEGTQK---------NDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRS 54 + + +++ GT D T T+ FG R++L++ FP +T +R L+S Sbjct: 8 FTAMCSDIIEHGTTTVGEKVRPHWEDGTPAYTIKKFGVCNRYDLREEFPALTLRRTALKS 67 Query: 55 IIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITT 114 + E+LW Q +N +H+ N IWD WADE+G +G YG Q DQ+ Sbjct: 68 AMDEVLWIYQKKSN--NVHDLNSHIWDAWADESGSIGKAYGYQVGQKSHYAEGDFDQMDR 125 Query: 115 VLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADG------KLSCQLYQRSC 168 VL L+N+P SRRI+ + + +L +M L PC + V L+ L QRS Sbjct: 126 VLYDLQNNPFSRRIMTNLYTFADLSEMNLYPCAFNAIYNVTQNPGDAKPTLNLLLVQRSQ 185 Query: 169 DVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLP 228 D+ +N+ YA+L+ M+AQ ++ G+ V D H+Y H+D +SR P Sbjct: 186 DILAANNWNVCQYAILLMMVAQVSGMQAGELVHMISDAHIYDRHVDIVRELISRPIFAAP 245 Query: 229 KLIIKRKPESIFDYRFEDFEIEGYDPHPGIK-APVAI 264 + + + + +D +E Y+ P +K P+A+ Sbjct: 246 HVSLNPDVTDFYAFTTDDLIVENYEHGPQVKNIPIAV 282 >UniRef50_B7C7C1 Putative uncharacterized protein n=1 Tax=Eubacterium biforme DSM 3989 RepID=B7C7C1_9FIRM Length = 287 Score = 261 bits (668), Expect = 1e-68, Method: Composition-based stats. Identities = 92/279 (32%), Positives = 142/279 (50%), Gaps = 19/279 (6%) Query: 4 YLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFL 63 Y L + +L+ G Q ++RTG T+ I ++ FP++TTK+ +R + E+LW Sbjct: 8 YCGLCKDILENGVQVHNRTGIDTIKIPSAHFHLDVSKEFPILTTKQLFIRQAVTEMLWIY 67 Query: 64 QG-DTNIAYLHENNVTIWDEW-ADENGD------------LGPVYGKQWRAWPTPDGRHI 109 Q ++ +L E NV IWD+W +E+GD P + + Sbjct: 68 QAQSNDVRWLQERNVHIWDKWEINEDGDWIDENTGNVLKHFDPSFAHTIGTAYGYIVKKY 127 Query: 110 DQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCD 169 D + +LN LKND + RR ++S W ELD L C ++ V DGKL+ ++QRSCD Sbjct: 128 DLMNKLLNSLKNDKEDRRRVISLWQDSELDTAVLPSCVWSSEWDVTDGKLNIWVHQRSCD 187 Query: 170 VFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPR---- 225 V LGLPFN+ YA+L+ M+AQ L+ G W+ D H+Y N +D QL+R Sbjct: 188 VPLGLPFNVTQYAVLLMMVAQVTGLKPGTIDWSIKDAHIYVNQVDGIKEQLNRYETKGSL 247 Query: 226 PLPKLIIKRKPESIFDYRF-EDFEIEGYDPHPGIKAPVA 263 P P+L + +D+ +D ++ GY+ I P+A Sbjct: 248 PAPELWLNPDVTDFYDFDPTKDVKLNGYEHMGKISFPLA 286 >UniRef50_Q8RGP6 Thymidylate synthase n=10 Tax=Fusobacterium RepID=TYSY_FUSNN Length = 275 Score = 260 bits (664), Expect = 5e-68, Method: Composition-based stats. Identities = 87/271 (32%), Positives = 135/271 (49%), Gaps = 14/271 (5%) Query: 4 YLELMQKVLDEG--------TQKNDRTGTGTLSIFGHQMRFNLQD-GFPLVTTKRCHLRS 54 Y +++ + ++G T+ D T S G+Q R + D L+T++ ++ Sbjct: 9 YKDIVDTIAEKGIWSEGNVRTKYADGTAAHYKSYIGYQFRLDNSDDEAHLITSRFAPSKA 68 Query: 55 IIHELLWFL-QGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQIT 113 I EL W N+ L+E WDEW ++G +G YG Q Q+ Sbjct: 69 PIRELYWIWILQSNNVDVLNELGCKFWDEWKMQDGTIGKAYGYQI---AQETFGQKSQLH 125 Query: 114 TVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLG 173 V+N+LK +P+SRRI+ W EL +MAL PC Q+ V KL ++ QRSCDV LG Sbjct: 126 YVINELKKNPNSRRIMTEIWIPNELSEMALTPCVHLTQWSVIGNKLYLEVRQRSCDVALG 185 Query: 174 LPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIK 233 L N+ Y++L ++A +C LE + +W + H+Y H D+ Q++RE K+ I Sbjct: 186 LVANVFQYSVLHKLVALECGLEPAEIIWNIHNMHIYDRHYDKLIEQVNRETFEPAKIKIN 245 Query: 234 RKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 +SIFD++ +D EI Y + VAI Sbjct: 246 -NFKSIFDFKPDDIEIIDYKYGEKVSYEVAI 275 >UniRef50_Q934U8 Putative thymidylate synthase n=1 Tax=Salmonella enterica subsp. enterica serovar Typhi RepID=Q934U8_SALTI Length = 371 Score = 257 bits (657), Expect = 3e-67, Method: Composition-based stats. Identities = 117/350 (33%), Positives = 161/350 (46%), Gaps = 88/350 (25%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDG-FPLVTTKRCHLRSIIHELLW 61 Y ++++ VL+ G DRTGTGT S+ + L G PL++ K +L+ ++ EL W Sbjct: 22 SYAKVVETVLNSGVHAGDRTGTGTKSVSYVPSYYMLTGGSVPLISGKAVNLKPLLVELEW 81 Query: 62 FLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPD---------------- 105 +L+G NI +L +N V IWD WADENGDLGPVYGKQWR W Sbjct: 82 YLKGTGNIQFLKDNGVKIWDAWADENGDLGPVYGKQWRRWEDTRIVSHSEYLSKIDTFRE 141 Query: 106 ------------------GRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCH 147 R IDQ+ +++ L+ +P RRI+++AWNVGEL+ M L PCH Sbjct: 142 RGYKVEGYLGVSEDRVVLSREIDQLQRIVHTLRTNPTDRRILLNAWNVGELEDMKLPPCH 201 Query: 148 AFFQFYV------------------------------------ADGK------------- 158 F + DG Sbjct: 202 FVFSLWSRKLDFETRLTMATDIGIQHNRHGHESIYTQMLCLLERDGGITENLLDELGIPK 261 Query: 159 --LSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQT 216 L+ L QRS D F+G+PFNIA Y +L H +A+ G FV G D HLY NHM Sbjct: 262 RILNSCLVQRSVDTFVGMPFNIAGYGILTHFLAKITGHMAGAFVHFGFDVHLYDNHMGGV 321 Query: 217 HLQLSREP--RPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 + REP P +I + + D+++E ++ GY P P IK PVA+ Sbjct: 322 EELMKREPPKESDPVVIFPHEWAELDDFKWEGVQVCGYSPLPWIKVPVAV 371 >UniRef50_C3IV33 Thymidylate synthase n=2 Tax=Bacillus thuringiensis RepID=C3IV33_BACTU Length = 306 Score = 257 bits (656), Expect = 3e-67, Method: Composition-based stats. Identities = 82/263 (31%), Positives = 129/263 (49%), Gaps = 22/263 (8%) Query: 19 NDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVT 78 D + T IFG R++L FP TT+ L++I E+ W + +N +++ Sbjct: 49 EDGSPIATKRIFGVVNRYDLSKEFPAPTTRPLPLKTIFDEVDWIYRKRSN--NVNDMRAK 106 Query: 79 IWDEWA-----------------DENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKN 121 IW++WA ++ G +G YG Q P + +Q+ VL +LK Sbjct: 107 IWNQWAFKKTRLRFSKTFPFVRLEKKGSIGEAYGYQV---AKPIFGYDNQMDYVLGELKR 163 Query: 122 DPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASY 181 DP +RR ++ WNV + +M L PC QF+ K + L QRS D FN+ Y Sbjct: 164 DPFTRRAVIEMWNVDDTGRMNLPPCAHHLQFWSDGKKTNLILKQRSQDFVTANAFNVCEY 223 Query: 182 ALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFD 241 A+L+HM+A+ EVG+ + GD H+Y+ H++ + REP P L I + + Sbjct: 224 AILLHMVARHIGQEVGELLHIIGDCHIYNKHLELAEELVKREPYAAPTLWINPEKTDFYS 283 Query: 242 YRFEDFEIEGYDPHPGIKAPVAI 264 + +DF +E YD HP +K VA+ Sbjct: 284 FTADDFRLENYDKHPQMKIEVAV 306 >UniRef50_B9LR89 Thymidylate synthase n=4 Tax=Halobacteriaceae RepID=B9LR89_HALLT Length = 342 Score = 256 bits (655), Expect = 5e-67, Method: Composition-based stats. Identities = 119/344 (34%), Positives = 162/344 (47%), Gaps = 84/344 (24%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRC---HLRSIIH 57 M+QYL+L+ L GT K +RTG T++ F Q +L +GFPL+TTK+ S+IH Sbjct: 1 MQQYLDLVDDTLSTGTYKPNRTGVDTIATFSGQYTVDLSEGFPLLTTKKMDGYRWNSLIH 60 Query: 58 ELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDG----------- 106 E+LW+L G+ +I L E IWD WAD+ G L YG+ WR +P PDG Sbjct: 61 EVLWYLSGEEHIRDLREET-KIWDAWADDEGRLDTAYGRFWRRFPVPDGVDALPGETWPK 119 Query: 107 -----------------RHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAF 149 R DQI VL+ L +P SRR++V+AW+ L PCH Sbjct: 120 DAHRWVTVEEGPEGVERRTFDQIQYVLDTLDENPRSRRMVVNAWHPANAAVSTLPPCHYT 179 Query: 150 FQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLY 209 F V DG+L+ L QRS D+ LG+PFNIA+YALL + +AQ+ E+G+F T D H+Y Sbjct: 180 FVVNVQDGRLNLHLTQRSGDIALGVPFNIAAYALLANALAQRTGFEIGEFGHTVVDAHIY 239 Query: 210 S--------------------------------------------------NHMDQTHLQ 219 +H+ Q Sbjct: 240 CGRGDRGQWYANNLRYVQDRLATVESKADYLDVKSWVERTAPDEADGEERYDHVPGLLEQ 299 Query: 220 LSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263 LSREPR P++ I KP + + +ED E+ YD GI VA Sbjct: 300 LSREPRERPRIEIADKP--LDELTYEDIEVVDYDSADGISFAVA 341 >UniRef50_C5H7L6 Thymidylate synthase n=3 Tax=unclassified Myoviridae RepID=C5H7L6_9CAUD Length = 299 Score = 252 bits (645), Expect = 7e-66, Method: Composition-based stats. Identities = 95/297 (31%), Positives = 149/297 (50%), Gaps = 33/297 (11%) Query: 1 MKQ----YLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSII 56 M Q Y ++ VL G + RTG + + RF+++ GFPL+T+K+ R +I Sbjct: 1 MSQADSSYKNILNHVLSVGELRTTRTGDVISAFAPPKFRFDMRTGFPLLTSKQVFTRQVI 60 Query: 57 HELLWFLQGDTNIAYLH-----ENNVTIWDEWADENGDL----------------GPVYG 95 E LWFL G+ + L EN+ W W+D+ G +YG Sbjct: 61 GEALWFLNGENKLGELRYRTWGENDGERWTIWSDDFKRWLSSNYSSEQDWLEDAGGRIYG 120 Query: 96 KQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGEL--DKMALAPCHAFFQFY 153 QWR + +G +DQ+ T++ ++K D R ++V+AWN ++ + MALAPCH FQ Y Sbjct: 121 VQWRNFEGHNGCVVDQLETLVTKMKGDITDRYMLVNAWNAADIAANSMALAPCHVLFQIY 180 Query: 154 VAD-GKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNH 212 + + G++ Q YQRS D FLGLPFNIASY ++ ++ + + GDT +Y NH Sbjct: 181 ITNEGEVDLQWYQRSVDTFLGLPFNIASYGFILEVLCKMTGYTPRYLIGVFGDTQIYQNH 240 Query: 213 MDQTHLQLSREPRPLPKLIIKRKPESIFDYRF---EDFE--IEGYDPHPGIKAPVAI 264 M Q + ++ E P I + ++ D + DF I Y I+AP+++ Sbjct: 241 MKQVYELMNNEEFHAPTFEIGVQLNTLSDLKHLTASDFIGGINNYQHAGKIEAPLSV 297 >UniRef50_C6JM98 Thymidylate synthase n=6 Tax=Fusobacterium RepID=C6JM98_FUSVA Length = 276 Score = 252 bits (643), Expect = 1e-65, Method: Composition-based stats. Identities = 86/270 (31%), Positives = 135/270 (50%), Gaps = 11/270 (4%) Query: 2 KQYLELMQK--VLDEG---TQKNDRTGTGTLSIFGHQMRFN-LQDGFPLVTTKRCHLRSI 55 K+ +E++ K + EG T+ D T S G+Q R + D L+TT+ ++ Sbjct: 11 KEIVEIIDKNGIWSEGNVRTKYADGTPAHYKSYIGYQFRLDNSTDEAHLITTRFAPNKAP 70 Query: 56 IHELLWFL-QGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITT 114 I EL W ++ L++ WDEW +G +G YG Q + Q+ Sbjct: 71 IRELYWIWIMQSNDVDELNKLKCKFWDEWKMNDGTIGKAYGYQI---AKQTFGYKSQLDY 127 Query: 115 VLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGL 174 V+ +LK +P+SRRI+ W +LDKMAL PC Q+ V KL ++ QRSCDV LGL Sbjct: 128 VIGELKKNPNSRRIMTEIWVPEDLDKMALTPCVHLTQWSVIGNKLYLEVRQRSCDVALGL 187 Query: 175 PFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKR 234 N+ Y++L ++A +C+LE + +W + H+Y HM Q+ R + I+ Sbjct: 188 VANVFQYSILHKLVAMECNLEPAEIIWNIHNVHIYDRHMPDLLEQIKRPSIDGATVKIE- 246 Query: 235 KPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 +SI+D++ +D +E Y I VAI Sbjct: 247 NFKSIYDFKPDDVVVENYQYGEKISYEVAI 276 >UniRef50_A2SMX7 Thymidylate synthase n=1 Tax=Methylibium petroleiphilum PM1 RepID=A2SMX7_METPP Length = 316 Score = 242 bits (617), Expect = 1e-62, Method: Composition-based stats. Identities = 89/316 (28%), Positives = 137/316 (43%), Gaps = 56/316 (17%) Query: 1 MKQYLELMQKVLDEGTQK-NDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHEL 59 M+Q+ +++Q +LD G+++ N RTG L + G+ +RF++ DGFP +TTK+ + EL Sbjct: 1 MQQFHDMLQHILDHGSRQLNARTGEEVLFVPGYTLRFDMADGFPAITTKQLFFKMAKGEL 60 Query: 60 LWFLQGDTNIAYLHENNVTIWDEWA---------------DENGDLGPVYGKQWRAWPTP 104 F +G T+ A E T+W++ A D+ G G + WR W Sbjct: 61 FGFFRGFTSAAQFREIGCTVWNDNANKTKAWLANPYRQGEDDLGRFGYLQWTDWRDWREA 120 Query: 105 D---------------------------GRHIDQITTVLNQLKNDPDSRRIIVSAWNVGE 137 R I+Q+ T L+ + +P R II+S WN E Sbjct: 121 TTPAQRDEMLAQGYEVRAHDAERGVWILRRSINQLETSLHAVMTNPSDRGIILSGWNPAE 180 Query: 138 LDKMALAPCH--AFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLE 195 +D+ AL CH Q VA G L L+QRS D L +N+A A+ + +MA+ L+ Sbjct: 181 IDQGALRSCHVSYMLQVDVATGTLHLTLWQRSFDAPLA--YNVAIGAMYLEIMARLAGLK 238 Query: 196 VGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPES---------IFDYRFED 246 G F D H+Y+ H+ L+RE P P L + P Sbjct: 239 AGTFTHFISDAHIYAKHIPGVKEMLAREHFPQPTLDLGNIPTLTSAAEIPGIFATLDPNQ 298 Query: 247 FEIEGYDPHPGIKAPV 262 ++ Y HP I + Sbjct: 299 VKLVNYQHHPKIAFEM 314 >UniRef50_A8E2Q5 Putative thymidylate synthase n=1 Tax=Enterococcus phage phiEF24C RepID=A8E2Q5_BPPHE Length = 315 Score = 239 bits (610), Expect = 8e-62, Method: Composition-based stats. Identities = 90/309 (29%), Positives = 135/309 (43%), Gaps = 48/309 (15%) Query: 4 YLELMQKVLDEGTQK---------NDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRS 54 Y +L+ ++ G + D T T I G G PL+ +K ++ Sbjct: 7 YKDLVMDIIKNGVTELPEGTRAVYADGTPATTKFIEGVNFTITPDMGAPLLRSKHVGIKW 66 Query: 55 IIHELLWFLQ-GDTNIAYLHENNVTIWDEWADENGDLGPVYGK----------------- 96 + EL W Q +++L E VTIWDEW E+G +G YG Sbjct: 67 ALTELQWIWQEMSNEVSWLKERGVTIWDEWEQEDGTIGKAYGYALFNKERFIPVYSGDVE 126 Query: 97 -------------------QWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGE 137 W A ++Q+ V+ QLK+ P+SRRI+ + WNV + Sbjct: 127 LAKNRKAGSLIPKVVPKKGGWIAGTHQPYLKLNQVEAVIEQLKSTPNSRRIMTTLWNVED 186 Query: 138 LDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVG 197 L M+L PC + V +GKL+ + RS DV LGLPFNI Y L +MA LE+G Sbjct: 187 LYDMSLEPCVWTTHWTVVEGKLNLHVKARSSDVCLGLPFNIIQYHALQLVMANTVGLELG 246 Query: 198 DFVWTGGDTHLYSNHMDQTHLQLSRE-PRPLPKLIIK-RKPESIFDYRFEDFEIEGYDPH 255 + WT + H+Y H++ Q++ P +PKL++ +K + FD D + Y + Sbjct: 247 NLYWTSDNAHIYERHLELVEKQVNEPIPEEVPKLVLPWKKGTNFFDSPLSDISVINYKHN 306 Query: 256 PGIKAPVAI 264 VAI Sbjct: 307 GKFNYEVAI 315 >UniRef50_B8QTX3 Putative thymidylate synthase n=1 Tax=Erwinia phage phiEa21-4 RepID=B8QTX3_9CAUD Length = 311 Score = 231 bits (589), Expect = 2e-59, Method: Composition-based stats. Identities = 95/306 (31%), Positives = 139/306 (45%), Gaps = 44/306 (14%) Query: 2 KQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLW 61 +QY +L G ++ R+G F +R +++ FPL+T K + + ELLW Sbjct: 6 QQYKAFTANILSNGELRHSRSGNTISVPFPEDLRIDVRKEFPLLTCKSVPMSLVAGELLW 65 Query: 62 FLQGDTNIAYLH-------ENNVTIWD---------------------------EWADEN 87 FL G T++ L E TIW D Sbjct: 66 FLAGKTDLHSLRMYQFGSDEGQNTIWTADYERYSKAVKSLIRKVQTGESQEKTLRKIDAQ 125 Query: 88 GDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKM--ALAP 145 DLG +YG QWR + + D DQIT ++ +K +P SR IVSAWN + AL P Sbjct: 126 EDLGMIYGSQWREFESCD-TTCDQITRLIEGIKENPASRYHIVSAWNPVAVANNLGALPP 184 Query: 146 CHAFFQFYVAD-GKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGG 204 CH FFQ Y ++ G + + YQRS D FLGLPFNIASYALL+ ++AQ + + G Sbjct: 185 CHMFFQVYASEGGYMDLRWYQRSVDTFLGLPFNIASYALLLRILAQMTGYTARYVIGSFG 244 Query: 205 DTHLYSNHMDQTHLQLSREPRPLPKLIIKR----KPESIFDYRFEDFE--IEGYDPHPGI 258 D H+Y NH+ + P L + +S+ F+ ++ Y + Sbjct: 245 DAHIYENHVPAVMQMMDNPEFDAPTLKLDNLDLSSLDSVLKLNGLVFKNALQDYQNAGVV 304 Query: 259 KAPVAI 264 KAP+++ Sbjct: 305 KAPLSV 310 >UniRef50_C7HUX5 Thymidylate synthase n=2 Tax=Anaerococcus RepID=C7HUX5_9FIRM Length = 287 Score = 230 bits (586), Expect = 5e-59, Method: Composition-based stats. Identities = 71/272 (26%), Positives = 130/272 (47%), Gaps = 19/272 (6%) Query: 2 KQYLELMQKVLDEGTQKNDRT---------GTGTLSIFGHQMRFNLQDG-FPLVTTKRCH 51 ++Y+++ +++L++G + + G + + Q + G PL++ ++ Sbjct: 5 EKYIKIAKEILEKGYDEEELNKEVRPVWDDGESAYTKYLPQQVVRYEKGELPLISLRKIA 64 Query: 52 LRSIIHELLWFLQG-DTNIAYLHENN-VTIWDEWADENGDLGPVYGKQW--RAWPTPDGR 107 +S I E+LW Q ++ L E V WD W +E+G+LG YG Q + G+ Sbjct: 65 WKSAIKEILWIYQDRSNDVNLLKEKYKVNYWDSWKNEDGNLGTAYGYQINKKFKSPETGQ 124 Query: 108 HIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRS 167 +QI +++Q+KN+P +RR+I++ +V ++ M L PC + V+ L+ L QRS Sbjct: 125 MTNQIERLIDQIKNNPLNRRLIMNLIDVDDMADMTLIPCAFLTMWTVSGEYLNLTLVQRS 184 Query: 168 CDVFLGL---PFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQL--SR 222 D N Y +L+ M+AQ + GDFV + H+Y H+ L Sbjct: 185 GDFLAAAAPGGINAFQYYVLLRMVAQVTGYKAGDFVHFIQNYHIYKKHIPSVKKILEIKV 244 Query: 223 EPRPLPKLIIKRKPESIFDYRFEDFEIEGYDP 254 + + P+L I + D+ +DF++ Y P Sbjct: 245 DEKSKPRLEINPDIKEFKDFTIDDFKLIDYYP 276 >UniRef50_Q6X183 Thymidylate synthase (Fragment) n=1 Tax=Enterobacteria phage TuIa RepID=Q6X183_9CAUD Length = 166 Score = 210 bits (534), Expect = 6e-53, Method: Composition-based stats. Identities = 79/166 (47%), Positives = 108/166 (65%), Gaps = 12/166 (7%) Query: 111 QITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDV 170 Q+ ++++K P+ RR IVSAWN E+D+MAL PCH F+QF V +G L Q YQRS DV Sbjct: 1 QLVKTIDRIKALPNDRRQIVSAWNPAEIDQMALPPCHMFYQFNVRNGHLDLQWYQRSVDV 60 Query: 171 FLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKL 230 FLGLPFNIASYA L H++A+ C+L GD V++GG+TH+YSNH++Q + REP+ L L Sbjct: 61 FLGLPFNIASYAALTHIVAKMCNLIPGDLVFSGGNTHIYSNHVEQCKEVIRREPKELCSL 120 Query: 231 II------KRKPESI-FDY-----RFEDFEIEGYDPHPGIKAPVAI 264 I + P I D+ DF ++ Y+ HP IKA +A+ Sbjct: 121 EITWPSNFENWPTKIQMDWVTGTMTHTDFVLKNYESHPAIKAKMAV 166 >UniRef50_C0ELR2 Putative uncharacterized protein n=1 Tax=Neisseria flavescens NRL30031/H210 RepID=C0ELR2_NEIFL Length = 309 Score = 208 bits (531), Expect = 1e-52, Method: Composition-based stats. Identities = 74/280 (26%), Positives = 122/280 (43%), Gaps = 34/280 (12%) Query: 2 KQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLW 61 +QY++L++ +LD +N+RTGT +I Q D FP +T +R + +S + E+L Sbjct: 21 QQYVQLLKDLLDAPLVRNERTGTACHTIINPQSFTYTADDFPALTIRRSYWKSAVAEMLG 80 Query: 62 FLQGDTNIAYLHENNVTIWDEWADEN------------GDLGPVYGKQWRAWPTPDGRHI 109 +++G T+ E WD A++N D+G VYG ++ Sbjct: 81 YIRGYTSAKDFRELGTKTWDANANQNPAWLANPHRAGVDDMGLVYGAVGNSFTGLS---- 136 Query: 110 DQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCD 169 T ++ + D+R +I S WN DK L PC QF + +G L QRSCD Sbjct: 137 --FTDIMRAIHARQDNRGLIWSFWNPDVFDKGCLRPCMYSHQFSIVNGTLYLTSTQRSCD 194 Query: 170 VFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLP- 228 V LGL FN+ L++++ L+ G + H+Y N +D ++ P Sbjct: 195 VPLGLTFNMIQCWFLLYLVCTLTGLKFGHARHNIVNAHIYENQVDAVREMIANPLLPRSI 254 Query: 229 ----------KLIIK-RKPESIFDY----RFEDFEIEGYD 253 ++ + +S + DFE+ GYD Sbjct: 255 KFQHVDRMTGRVRMGVEDVDSALLFLNSCDVNDFELLGYD 294 >UniRef50_Q7Y427 dTMP (Thymidylate) synthase n=3 Tax=unclassified T4-like viruses RepID=Q7Y427_9CAUD Length = 410 Score = 208 bits (529), Expect = 2e-52, Method: Composition-based stats. Identities = 78/158 (49%), Positives = 105/158 (66%), Gaps = 4/158 (2%) Query: 110 DQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCD 169 DQ+ V+ Q+KN+P RRII+ +WNV L CH F QFYV +GKLSC +QRS D Sbjct: 254 DQLQNVIEQIKNNPTDRRIIIDSWNVQGTHNAVLGVCHPFVQFYVNEGKLSCMWFQRSVD 313 Query: 170 VFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPK 229 FLGLPFN+ASYALL H++A+ CDLEVG+ +++GGDTH+Y NH DQ QLSR P P Sbjct: 314 SFLGLPFNVASYALLTHIIAKMCDLEVGELIFSGGDTHIYKNHFDQVMEQLSRVPFDKPT 373 Query: 230 LIIKRKPESIFD---YRFEDFEIEGYDPHPGIKAPVAI 264 + + + +S+ + +DF+I Y HP I A +A+ Sbjct: 374 IEL-PEFKSLDEVLTKTPKDFKIHNYQSHPAITAQMAV 410 Score = 108 bits (269), Expect = 2e-22, Method: Composition-based stats. Identities = 49/127 (38%), Positives = 67/127 (52%), Gaps = 18/127 (14%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL 60 MK+YL+L++ VLD G + DRTG GTLS FG +MR +L GFPL+TTK+ S+I ELL Sbjct: 1 MKEYLKLLRDVLDNGWPREDRTGVGTLSKFGAEMRIDLSKGFPLLTTKKMATASVIGELL 60 Query: 61 WFLQGDTNIAYLHENNVTIWDEWADE------------------NGDLGPVYGKQWRAWP 102 WF++G + L E +DE A + ++G +YG WR P Sbjct: 61 WFMEGSLDRRRLQEITRGKFDEEAFDIWRGNCLDMKEKNPLRFNGYNVGNMYGMAWRRKP 120 Query: 103 TPDGRHI 109 I Sbjct: 121 IHPHGEI 127 >UniRef50_Q03LN3 Thymidylate synthase n=75 Tax=Firmicutes RepID=TYSY_STRTD Length = 286 Score = 207 bits (527), Expect = 3e-52, Method: Composition-based stats. Identities = 79/279 (28%), Positives = 125/279 (44%), Gaps = 18/279 (6%) Query: 4 YLELMQKVLDEGT-------QKNDRTGTGTLSIFGHQMRFNLQDG-FPLVTTKRCHLRSI 55 + E + K+++EG + D T + I G ++L G FP+ T + ++S Sbjct: 8 FKENITKIMEEGVWSEQARPKYKDGTTANSKYITGSFAEYDLSKGEFPITTLRPIAIKSA 67 Query: 56 IHELLWFLQGDTNIAYLHE--NNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQIT 113 I E+ W Q TN + E NV W++W E + + D I Sbjct: 68 IKEVFWIYQDQTNSLDVLEDKYNVHYWNDWEVEGVPANNGDKRSIGQRYGAVVKKHDIIN 127 Query: 114 TVLNQLKNDPDSRRIIVSAWNVGELDKMA-LAPCHAFFQFYVA----DGKLSCQLYQRSC 168 +L QL+ +P +RR ++S W+ ++ A L PC F V D L L QRS Sbjct: 128 RLLAQLEANPWNRRNVISLWDYEAFEETAGLQPCAFQTMFDVRRVGEDVYLDATLTQRSN 187 Query: 169 DVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRP-L 227 D+ + N Y L M+A+ +VG F + + H+Y N +Q L R+P Sbjct: 188 DMLVAHHINAMQYVALQMMIAKHFGWKVGKFFYFINNLHIYDNQFEQAEELLKRQPSDCQ 247 Query: 228 PKLIIK-RKPESIFDYRFEDFEIEGYDP-HPGIKAPVAI 264 P+L++ + FD + EDFE+ YDP P +K +AI Sbjct: 248 PRLVLNVPDETNFFDIKPEDFELVDYDPVKPQLKFDLAI 286 >UniRef50_B4TEI9 Thymidylate synthase n=2 Tax=Enterobacteriaceae RepID=B4TEI9_SALHS Length = 326 Score = 196 bits (499), Expect = 6e-49, Method: Composition-based stats. Identities = 55/247 (22%), Positives = 102/247 (41%), Gaps = 14/247 (5%) Query: 6 ELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQG 65 ++ Q +L +G ND T TL I G + T R L S + E LW+L Sbjct: 16 DVHQAILADGLS-NDPTKGSTLEILGAYLVLTDPRRRISRTESRGKLISCLGEFLWYLSA 74 Query: 66 DTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDS 125 ++ ++ + + E A+ +G + YG + +Q+ V+N L+ + Sbjct: 75 QNDLEFIKH-FIPRYAESAESDGKIHGGYGPRLFNMRGL----YNQLKNVINLLQEKKPT 129 Query: 126 RRIIVSAWNVGEL-------DKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNI 178 RR ++ ++ +L + PC QF V +L + RS D F+GLP ++ Sbjct: 130 RRAVIQLFDASDLVPSKTEQREYVDIPCTISMQFIVRCEELHLFVCMRSNDAFMGLPHDV 189 Query: 179 ASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREP-RPLPKLIIKRKPE 237 ++ +L ++A+ E+G + HLY N +++ LP + + Sbjct: 190 FAFTMLQELVARLIGCELGHYHHFVSSLHLYKNDLEKVKALQKEGFMSTLPVMGSMPEMH 249 Query: 238 SIFDYRF 244 S+ D Sbjct: 250 SLDDILP 256 >UniRef50_B2IB94 Thymidylate synthase n=2 Tax=Rhizobiales RepID=B2IB94_BEII9 Length = 342 Score = 188 bits (478), Expect = 1e-46, Method: Composition-based stats. Identities = 60/251 (23%), Positives = 112/251 (44%), Gaps = 17/251 (6%) Query: 1 MKQYLELMQKVLDE---GTQKNDRTGTG----TLSIFGHQMRFNLQDGFPLVTTKRCHLR 53 M+ E + +L +++ RT G T+ + G +R + R Sbjct: 1 MEIEKECLDAILYNLYWSIKEHGRTNAGSRGNTVELLGVALRILKPRARISRSENRGKPF 60 Query: 54 SIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQIT 113 S I ELLW+L G +A++ E V+ + + A G + YG + RA IDQ Sbjct: 61 SAIGELLWYLSGLDTLAFI-EPYVSAYRDDA-VAGVIQGAYGPRLRAMRD----GIDQFA 114 Query: 114 TVLNQLKNDPDSRRIIVSAWNVGEL-DKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFL 172 ++ L+ P+SRR ++ +N ++ + PC QF++ DG L + RS D + Sbjct: 115 SIETLLRQKPNSRRAVIQLFNAEDIATEHKEIPCTTTLQFHLRDGLLHMSVTMRSNDAYW 174 Query: 173 GLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPR---PLPK 229 GLP ++ + ++ MMA++ +E+G++ G H+Y H++ L + +P Sbjct: 175 GLPHDVFCFTMIQEMMARRLGVELGEYYHYVGSMHVYEKHLNHLDNYLVEGFQRTAEMPP 234 Query: 230 LIIKRKPESIF 240 + + + Sbjct: 235 MPAGDPFQLVD 245 >UniRef50_Q13T72 Thymidylate synthase n=4 Tax=Burkholderiaceae RepID=Q13T72_BURXL Length = 354 Score = 185 bits (471), Expect = 1e-45, Method: Composition-based stats. Identities = 52/240 (21%), Positives = 106/240 (44%), Gaps = 16/240 (6%) Query: 2 KQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLW 61 K Y L++K G+ + T I G + + K+ L S + E LW Sbjct: 14 KVYGRLLRK---RGSDDINPTKGPATEINGALLVLKKPRARLSQSEKKNTLFSCLGEFLW 70 Query: 62 FLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKN 121 +L G + ++ ++ + +++D+ + YG + + DQ+ V+ L+ Sbjct: 71 YLAGSDKLDFIQ-YYISRYKDFSDDGKTVFGAYGPRLFGPTS----GTDQVQNVIQTLRA 125 Query: 122 DPDSRRIIVSAWNVGELDKMA-----LAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPF 176 + SRR ++ ++ +L PC QF++ + +L+ + RS D F+GLP Sbjct: 126 NQHSRRAVIQLFHGDDLAANLVKRREDLPCTCTLQFFIRNYQLNAMVTMRSNDAFMGLPH 185 Query: 177 NIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRP---LPKLIIK 233 +I ++ +L ++A+ +EVG + G HLY+N+ + L+ + +P + Sbjct: 186 DIFAFTMLQELIARSLGVEVGQYKHAVGSLHLYANNTQAVNDYLAEGFQESVSMPPMPAG 245 >UniRef50_B4Y380 MilA n=1 Tax=Streptomyces rimofaciens RepID=B4Y380_9ACTO Length = 334 Score = 181 bits (460), Expect = 2e-44, Method: Composition-based stats. Identities = 49/212 (23%), Positives = 82/212 (38%), Gaps = 6/212 (2%) Query: 4 YLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRF-NLQDGFPLVTTKRCHLRSIIHELLWF 62 YL ++ + +N G + G R + V +R ++ E LW+ Sbjct: 13 YLSQLRDIYHSPEFRNAPRGQASRERIGAGFRLLDPVQRHISVPARRANVVFNFAEALWY 72 Query: 63 LQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKND 122 L G + ++ I AD G YG + P ++Q V+ L +D Sbjct: 73 LSGSDRLDFIQYYAPGIAAYSADGRTLRGTAYGPRIFRHPA---GGVNQWENVVKTLTDD 129 Query: 123 PDSRRIIVSAWNVGELD--KMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIAS 180 PDS+R ++ ++ EL C QF + DG L Y R+ D F G ++ S Sbjct: 130 PDSKRAVIQIFDPRELAVADNIDVACTLALQFLIRDGLLCGIGYMRANDAFRGAVSDVFS 189 Query: 181 YALLVHMMAQQCDLEVGDFVWTGGDTHLYSNH 212 + L A+ L +G + G H+Y + Sbjct: 190 FTFLQEFTARYLGLGIGTYHHVVGSVHIYDSD 221 >UniRef50_UPI00016AD9CB thymidylate synthase n=1 Tax=Burkholderia thailandensis MSMB43 RepID=UPI00016AD9CB Length = 193 Score = 180 bits (457), Expect = 4e-44, Method: Composition-based stats. Identities = 60/171 (35%), Positives = 86/171 (50%), Gaps = 13/171 (7%) Query: 107 RHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQF--YVADGKLSCQLY 164 + IDQ+ L+ + DP SRRI+ WN LD++AL CH +QF V ++S LY Sbjct: 23 KAIDQLRDCLDTIVRDPSSRRILFHGWNPAVLDEIALPACHLLYQFLPNVERREISLCLY 82 Query: 165 QRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREP 224 RS DV LG PFN+A A L+ ++ + F + GD H+Y N +D QL REP Sbjct: 83 IRSNDVGLGTPFNLAEGAALLTLVGRLTGYTPRWFTYFIGDAHIYENQLDMLKQQLEREP 142 Query: 225 RPLPKLIIKR-----------KPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 P+L I +P+ + DF + GY H + AP+A+ Sbjct: 143 FESPRLEIAERVPDYAKTGEYEPQWLERIEPSDFALVGYRHHEPLTAPMAV 193 >UniRef50_A7TUR1 Putative thymidylate synthase n=3 Tax=Streptomyces RepID=A7TUR1_STRLI Length = 308 Score = 180 bits (457), Expect = 4e-44, Method: Composition-based stats. Identities = 63/255 (24%), Positives = 111/255 (43%), Gaps = 16/255 (6%) Query: 13 DEGTQKNDRTGTGTLSIFGHQMRFNLQDG--FPLVTTKRCHLRSIIHELLWFLQGDTNIA 70 G + + R G T + + F + + + E +W L G + Sbjct: 13 KSGEKISPR-GMATHEVRDVHLLLTQPRARLFYAPPARIVNPAFAVAETVWHLSGS-DAP 70 Query: 71 YLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIV 130 ++ + N + ++AD+ LG YG + R W G +DQ+ V+ L+ D DSRR ++ Sbjct: 71 WIFDYNYRL-RQFADDGVLLG-AYGPRMRNW----GGKVDQLARVVEILQADSDSRRALI 124 Query: 131 SAWNVG-ELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMA 189 ++ + PC F+F++ G+L R DV++G+P+++ Y +L ++A Sbjct: 125 QLYDPAQDAAGHKDVPCTLGFRFHLRAGRLHMATMMRGQDVWIGMPYDVFFYTVLHELVA 184 Query: 190 QQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRP-LPKLIIKRKPESIFDYRFEDFE 248 D E+G+F G H+Y H++Q S +P L R P + F + E Sbjct: 185 GWLDAELGEFHLHIGSLHIYDEHIEQADALTSLSASEIMPDL---RTPWTGFSGLLDQVE 241 Query: 249 IEGYDPHPGIKAPVA 263 HPG A +A Sbjct: 242 ARDVTGHPGWDA-MA 255 >UniRef50_B0T6R4 Thymidylate synthase n=1 Tax=Caulobacter sp. K31 RepID=B0T6R4_CAUSK Length = 367 Score = 180 bits (456), Expect = 5e-44, Method: Composition-based stats. Identities = 48/234 (20%), Positives = 98/234 (41%), Gaps = 12/234 (5%) Query: 18 KNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNV 77 + T T+ G + + H+ S I E +W++ + + E + Sbjct: 25 RVSATKGTTVEEHGVVLELTRPRARLSRAHMKGHVFSCIGEFIWYISCSNRLEPV-EYYI 83 Query: 78 TIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGE 137 + + ++A+++G + YG + G Q V L P +R+ ++ ++ + Sbjct: 84 SRYKKFAEKDGTVWGAYGPRIF------GGDRSQYEVVKEMLSERPSTRKAVIQLFDRED 137 Query: 138 -LDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEV 196 L PC QF V DG L+ ++ RS DV++GLP +I ++ ++ ++A ++ Sbjct: 138 VLQDYNDIPCTCTMQFLVRDGMLNLVVHMRSNDVYMGLPHDIFAFTMIQEILAHDLGFKL 197 Query: 197 GDFVWTGGDTHLYSNHMDQTHLQLSREPRP---LPKLIIKRKPESIFD-YRFED 246 G + G HLY + ++ L +P +P + + I + ED Sbjct: 198 GTYKHMVGSFHLYDHDREKVEQYLKEGFQPTREMPAMPSGNQWGHITALLKIED 251 >UniRef50_B3FJL1 Putative uncharacterized protein n=1 Tax=Pseudomonas phage 201phi2-1 RepID=B3FJL1_9CAUD Length = 457 Score = 179 bits (455), Expect = 6e-44, Method: Composition-based stats. Identities = 94/252 (37%), Positives = 120/252 (47%), Gaps = 74/252 (29%) Query: 87 NGDLGPVYGKQWRA-----------WPTPDGRHIDQITTV-------------------- 115 GDLG VYGK WR W + R D + V Sbjct: 206 GGDLGAVYGKTWRDIEDTRVIPKYDWVDYEARGFDFVVDVPGTSIENDRCVVTRRIDQIQ 265 Query: 116 --LNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVA------------------ 155 ++QL+ +PDSRRIIV AW +D+ AL PCH+FFQF+ Sbjct: 266 DIIDQLRTNPDSRRIIVCAWAPQLVDEQALPPCHSFFQFWTRELTVEERIKLLRTTKPEI 325 Query: 156 ----DGK-----------------LSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDL 194 DG +SC LYQRS D FLG PFNI Y+LL H +A Q ++ Sbjct: 326 YNVIDGTTGYFEHIADINDIPKRAISCHLYQRSVDAFLGKPFNITFYSLLTHWLANQLNM 385 Query: 195 EVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKP--ESIFDYRFEDFEIEGY 252 +FVWTGGD H+YSNH +QT LQL+REP+ LP + + + I + R EDFEI Y Sbjct: 386 VADEFVWTGGDCHIYSNHQEQTDLQLTREPKALPTIRFTPEAKGKDIREIRPEDFEILNY 445 Query: 253 DPHPGIKAPVAI 264 + HP I VA+ Sbjct: 446 EFHPHIAGKVAV 457 Score = 103 bits (257), Expect = 7e-21, Method: Composition-based stats. Identities = 45/84 (53%), Positives = 59/84 (70%), Gaps = 1/84 (1%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDG-FPLVTTKRCHLRSIIHEL 59 M+QYL+ + + + G K DRTGTGT S G Q R++L+D P++TTK+ HL SIIHEL Sbjct: 1 MQQYLDSIIDIKENGVFKGDRTGTGTQSKLGQQERYSLRDNTLPVITTKKIHLPSIIHEL 60 Query: 60 LWFLQGDTNIAYLHENNVTIWDEW 83 +W L GDT + YL EN V IW+EW Sbjct: 61 IWMLSGDTRVDYLIENGVRIWNEW 84 >UniRef50_B5S769 Putative thymidylate synthase protein n=1 Tax=Ralstonia solanacearum RepID=B5S769_RALSO Length = 294 Score = 177 bits (449), Expect = 4e-43, Method: Composition-based stats. Identities = 60/230 (26%), Positives = 96/230 (41%), Gaps = 18/230 (7%) Query: 12 LDEGTQKNDRTGTGTLSIFGHQMRF-NLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIA 70 L G Q+ G TL + + + + + +R + I EL W L+G + + Sbjct: 5 LQNG-QRTAPRGVATLELLPVAFTINDPRRRYVSLPPRRWSIVYAIGELCWHLRGSSLVD 63 Query: 71 YLHEN---NVTIWDEWADENG-DLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSR 126 + TI + G + G K R P+ Q + V+NQL+ D DSR Sbjct: 64 EIAYYASRWRTIAGNATEVTGSNYGAKIFKGHRGAPS-------QWSRVINQLRIDRDSR 116 Query: 127 RIIVSAWNVGEL--DKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALL 184 R ++ GE C QF + DGKL RS D LGLP+++ +++L Sbjct: 117 RAVLYFSGTGEDTSSDSKDIACAVSLQFLIRDGKLDAIANMRSNDAMLGLPYDVFLFSML 176 Query: 185 VHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLS---REPRPLPKLI 231 M A ++VG + G HLY + + +S E RP+P++ Sbjct: 177 QEMAANSLGVDVGKYNHVAGSLHLYESDLLLAKDIISSRASEIRPMPRME 226 >UniRef50_C4SF99 Deoxyuridylate hydroxymethyltransferase n=1 Tax=Yersinia mollaretii ATCC 43969 RepID=C4SF99_YERMO Length = 335 Score = 175 bits (443), Expect = 2e-42, Method: Composition-based stats. Identities = 48/205 (23%), Positives = 94/205 (45%), Gaps = 8/205 (3%) Query: 37 NLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGK 96 N ++ F ++ ++ ++ + + E +W L G ++ +L E++D+N YG Sbjct: 20 NPRERFLVIPERKNNVFAQLAETIWVLAGRGDLEFLQHYLPRSI-EFSDDNKTWRAAYGP 78 Query: 97 QWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNV-GELDKMALAPCHAFFQFYVA 155 + R W DQ++ V+++L+ DP+++R ++S ++ + PC+ + QF Sbjct: 79 RLRNW----MGKTDQVSCVISRLQEDPNTKRAVMSLFDPMSDYSDTKDVPCNNWLQFIQR 134 Query: 156 DGKLSCQLYQRSCDVFLGL-PFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMD 214 D L + R+ D G N +++L ++A +VG W G H+YS H + Sbjct: 135 DNILYLHVTVRANDAIWGFSGINFFEWSVLHEIVATTLGYQVGTLSWYVGTFHIYSRHYN 194 Query: 215 QTHLQLSREPRPLPKLIIKRKPESI 239 + L R P +P SI Sbjct: 195 TSRDLL-RIKNPKSPYECGIEPTSI 218 >UniRef50_P31654 Deoxyuridylate hydroxymethyltransferase n=2 Tax=Bacillus phage SPO1 RepID=DUHM_BPSP1 Length = 383 Score = 173 bits (438), Expect = 7e-42, Method: Composition-based stats. Identities = 59/269 (21%), Positives = 117/269 (43%), Gaps = 20/269 (7%) Query: 4 YLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRF-NLQDGFPLVTTKRCHLRSIIHELLWF 62 Y++++ V+ EG R G I + F N + + + + E LW Sbjct: 13 YMDILSTVIKEGDVLAPR-GKRIKEIRPVMIEFKNPIRRTTFLKGRNINPFFQVAESLWI 71 Query: 63 LQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHI-----DQITTVLN 117 L G +++ +L + N + +++D+ YG++ R W D + DQ+ V Sbjct: 72 LAGRSDVGFLLDYNKNM-GQFSDDGVFFNAPYGERLRFWNRSDANNFIYNPLDQLRDVYE 130 Query: 118 QLKNDPDSRRIIVSAWNV---GELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLG- 173 ++K DPD+R+ + +N + PC+ F + +GKL +Y RS D+ G Sbjct: 131 KIKADPDTRQAVAVIYNPLFDNINNDTKDRPCNLLLSFKLRNGKLDLSVYNRSNDLHWGT 190 Query: 174 LPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIK 233 N+ ++ ++ MA +EVG + H+Y +D +++ + + + + ++ Sbjct: 191 FGANLCQFSTILEAMATWLGVEVGSYYQITDSLHVY---LDDYGAKITEDIQKVYGVNLE 247 Query: 234 RKPESIFDYRFEDFEIEGYDPHPGIKAPV 262 + EDFE E DP+P + + Sbjct: 248 TDEAPV----VEDFE-ELLDPNPRMSYTM 271 >UniRef50_Q1ZMM6 Thymidylate synthase n=3 Tax=Gammaproteobacteria RepID=Q1ZMM6_PHOAS Length = 187 Score = 170 bits (431), Expect = 4e-41, Method: Composition-based stats. Identities = 64/186 (34%), Positives = 96/186 (51%), Gaps = 14/186 (7%) Query: 1 MKQYLELMQKVLDEGTQ-KNDRTGTGTLSIFGHQMRFNLQDG-FPLVTTKRCHLRSIIHE 58 MKQYL L Q+++D+G +N+RTG L++ + +++ + FPL+TT++ ++ I E Sbjct: 1 MKQYLALCQRIVDDGVWIENERTGKRCLTVINADLTYDVANNQFPLITTRKSFWKAAIAE 60 Query: 59 LLWFLQGDTNIAYLHENNVTIWDEWADEN------------GDLGPVYGKQWRAWPTPDG 106 LL +L+G N A W+ A++N D+G VYG Q R W DG Sbjct: 61 LLGYLRGYDNAAQFRAIGCNTWNANANDNQAWLNNPHRKGEDDMGRVYGVQGRRWQKSDG 120 Query: 107 RHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQR 166 IDQ+ +++ L D R I++ +N GE D L PC F + L YQR Sbjct: 121 TPIDQLKKIVDDLTKGIDDRGEILTFYNPGEFDMGCLRPCMHTHTFSLLGDTLYLTSYQR 180 Query: 167 SCDVFL 172 SCDV L Sbjct: 181 SCDVPL 186 >UniRef50_B2HI72 Thymidylate synthase, ThyA_1 n=1 Tax=Mycobacterium marinum M RepID=B2HI72_MYCMM Length = 316 Score = 168 bits (426), Expect = 2e-40, Method: Composition-based stats. Identities = 53/237 (22%), Positives = 96/237 (40%), Gaps = 13/237 (5%) Query: 21 RTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIW 80 T T + G + T R R+ I +L W+L G TN + Sbjct: 30 PTRAPTRELIGVSLELTEPRCRLSRTEARRLSRTGIAQLAWYLSGTTNPEMILHWVPN-H 88 Query: 81 DEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELD- 139 + +G + YG R + T D Q TVL LK SRR ++ ++ +L Sbjct: 89 RNELEADGTIHGAYGP--RMFGTGDNA---QFCTVLELLKTSSSSRRAVIQLFDATDLTG 143 Query: 140 --KMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVG 197 + PC QF+V D +L + RS D ++GLP ++ ++ +L +MA + + +G Sbjct: 144 PGRYKDVPCTNTLQFFVRDSRLHLMVTMRSNDAYIGLPLDVFAFTMLQELMAGELGIGIG 203 Query: 198 DFVWTGGDTHLYSNH----MDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIE 250 ++ + G H+Y + +D P+P + + + + + +I Sbjct: 204 RYIHSVGSLHIYEYNKEAIIDFLAEGWQSTDTPMPAMPAQSLTRHVPQFLASELQIR 260 >UniRef50_C8S1P3 Thymidylate synthase n=1 Tax=Rhodobacter sp. SW2 RepID=C8S1P3_9RHOB Length = 358 Score = 167 bits (424), Expect = 3e-40, Method: Composition-based stats. Identities = 44/246 (17%), Positives = 90/246 (36%), Gaps = 17/246 (6%) Query: 15 GTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHE 74 G D + + +FG + + + S + EL W+L G + ++ Sbjct: 25 GNFVVDSSKGKSTEVFGALLELKNPRARLSRSFSKAKAFSPLGELFWYLSGSDRVEFIKH 84 Query: 75 NNVTIWDEWADENGDLGPVYGKQWRAWPTPDGR-HIDQITTVLNQLKNDPDSRRIIVSAW 133 + + + YG + R + V+ L+ SR +V + Sbjct: 85 YIPN-YPKLIKDEVTANGAYGPRIFGKEALAKRDGASEWDRVIRTLREREGSRNALVQIY 143 Query: 134 -NVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQC 192 N K PC QF + +G+L + RS D F GLP ++ ++ +L + A++ Sbjct: 144 DNSDAKPKNGDKPCTCTIQFAIRNGQLLMHTHMRSNDAFFGLPHDVFTFTMLQEIAAREL 203 Query: 193 DLEVGDFVWTGGDTHLYSNH--------------MDQTHLQLSREPRPLPKLIIKRKPES 238 L +G + + HLY + + + + + P+P++ + +S Sbjct: 204 GLGLGRYSHSVTSLHLYHDSAATKGRPANLSTSGAEAYYREGFHDYSPMPEMPLGNPWKS 263 Query: 239 IFDYRF 244 I + Sbjct: 264 IEQVKI 269 >UniRef50_Q03W75 Thymidylate synthase n=13 Tax=Bacteria RepID=Q03W75_LEUMM Length = 335 Score = 163 bits (414), Expect = 4e-39, Method: Composition-based stats. Identities = 50/245 (20%), Positives = 105/245 (42%), Gaps = 9/245 (3%) Query: 4 YLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVT-TKRCHLRSIIHELLWF 62 Y+ + ++ N+ G + G + + + T++ ++ E LW+ Sbjct: 11 YIAELNEIYHHAEFFNEPRGFSSREKLGVHFKIENPVQRIVYSQTRKTNIIFNFAEALWY 70 Query: 63 LQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKND 122 L G+ +++Y+ N + D D G YGK+ + ++++Q V +L ND Sbjct: 71 LTGNNSLSYISYYNKRMPDYSMDGQTLTGTAYGKKLFHFG---EQNLNQWQNVKQELLND 127 Query: 123 PDSRRIIVSAWNVGEL--DKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIAS 180 DS+R ++ ++ EL ++ C QF + + +L+ Y R+ D F G+ +I S Sbjct: 128 ADSKRAVIQIFDAHELTINQNLDVSCTLGLQFLIRNNQLNMVAYMRANDAFRGIVSDIFS 187 Query: 181 YALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSR---EPRPLPKLIIKRKPE 237 + + MA++ +L+VG + + G H+Y L+ + PK+ Sbjct: 188 FTFIQEFMARELNLKVGKYYHSVGTMHIYEPDNQWVTHVLNESNDQTFISPKMPQGNNWA 247 Query: 238 SIFDY 242 + + Sbjct: 248 MVHEL 252 >UniRef50_Q8MVZ9 Bifunctional dihydrofolate reductase-thymidylate synthase (Fragment) n=1 Tax=Cercomonas longicauda RepID=Q8MVZ9_9EUKA Length = 314 Score = 163 bits (414), Expect = 5e-39, Method: Composition-based stats. Identities = 61/167 (36%), Positives = 94/167 (56%), Gaps = 22/167 (13%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDG-FPLVTTKRCHLRSIIHELLW 61 +Y++L++++ D+G + DRTG G +FG+ M+F+L++G PL+T ++ + ++ ELLW Sbjct: 148 EYIDLIRRIRDQGEIRTDRTGVGIKCVFGNMMKFSLENGQIPLLTIRKIFWKGVVEELLW 207 Query: 62 FLQGDTNIAYLHENNVTIWDEWADEN------------GDLGPVYGKQWRA--------W 101 L+G T+ L E V IW GDLGP+YG QWR Sbjct: 208 MLRGKTHSRDLEEKGVNIWRANGSREALDRLGMVDREVGDLGPIYGWQWRHSGAXYTTAH 267 Query: 102 PTPDGRHIDQITTVLNQLKNDP-DSRRIIVSAWNVGELDKMALAPCH 147 G +DQI V++QL+N P +RRI+ +WN +L +MAL PCH Sbjct: 268 TDYSGFGVDQIKDVISQLQNQPQKNRRILFCSWNPKDLKQMALPPCH 314 >UniRef50_B5UXF4 Thymidylate synthase n=1 Tax=Bacillus cereus AH1134 RepID=B5UXF4_BACCE Length = 326 Score = 163 bits (412), Expect = 7e-39, Method: Composition-based stats. Identities = 50/246 (20%), Positives = 102/246 (41%), Gaps = 10/246 (4%) Query: 4 YLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQD--GFPLVTTKRCHLRSIIHELLW 61 YL L+ + + + D + +D P++ + + + E W Sbjct: 13 YLNLLVEAITKKVNITDSRNGPVKDLGPAYFEITNEDLLRVPILQERALNPFFALTEFSW 72 Query: 62 FLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKN 121 + G + L+ N + +D ++D+ L YG + R +DQ+ + L+ Sbjct: 73 IITGSNRLTPLN-NFINDFDRFSDDGFTLNGAYGHRLRELH-----GLDQLEKSIRILQE 126 Query: 122 DPDSRRIIVSAWNVGELDKMA-LAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIAS 180 + +RR++++ W++ +L + PC+ + + L + RS D+FLG+P+N+ Sbjct: 127 EKSTRRVVLTMWHIDDLGSNSRDIPCNISIMLKIRNNLLDMTVINRSNDLFLGVPYNVVV 186 Query: 181 YALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIF 240 + LL +A++ +VG HLYS H ++ + K + K E I Sbjct: 187 FYLLQCYIAKKIGCKVGVQRHFTDSLHLYSQHFEKVQSIIQNNNLERIKY-MYEKFEKID 245 Query: 241 DYRFED 246 + D Sbjct: 246 LSTYID 251 >UniRef50_UPI00016AEAE5 thymidylate synthase n=1 Tax=Burkholderia thailandensis MSMB43 RepID=UPI00016AEAE5 Length = 288 Score = 160 bits (404), Expect = 5e-38, Method: Composition-based stats. Identities = 47/221 (21%), Positives = 96/221 (43%), Gaps = 12/221 (5%) Query: 8 MQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLR-SIIHELLWFLQGD 66 + ++ EG + R G ++ + + + L+D V + R + + ELL + G Sbjct: 34 IHNIVKEGRKIKSRAGD---AMQAYGVNYILKDPRSRVHSLRNGAKRYLCRELLAYFSGS 90 Query: 67 TNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSR 126 N W D++G++ YG + P ++ +Q +++ LK++ DSR Sbjct: 91 LKAENGLANASKFWMTLTDKDGNVNSNYGY--YVFYEPVEKYGNQYNWIVSMLKSNQDSR 148 Query: 127 RIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVH 186 R I++ PC QF++ + L C+ RS DV GLP+++ ++ + Sbjct: 149 RAIININQNYHKSDTKDFPCTIGMQFFIRENHLFCETISRSTDVITGLPYDMGFFSFVHE 208 Query: 187 MMAQQC------DLEVGDFVWTGGDTHLYSNHMDQTHLQLS 221 ++ DL++G + T +Y N M++ ++ Sbjct: 209 LVHSDLVSQGYDDLQLGSTIMKTTFTQIYDNAMEKAKDAMN 249 >UniRef50_Q2T5Q0 Deoxyuridylate hydroxymethyltransferase , putative n=20 Tax=Burkholderia RepID=Q2T5Q0_BURTA Length = 329 Score = 160 bits (404), Expect = 6e-38, Method: Composition-based stats. Identities = 49/247 (19%), Positives = 101/247 (40%), Gaps = 15/247 (6%) Query: 4 YLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTK-RCHLRSIIHELLWF 62 YL + V ++ G I G+ R + + ++ E LW+ Sbjct: 11 YLATLSDVCGAYEFRSAPRGHAEREIIGYGARIDDPRARFCRRAARKQNVVFNYAEALWY 70 Query: 63 LQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQL-KN 121 L G ++ ++ ++ D G YG + + R +DQI L+ L ++ Sbjct: 71 LSGRNDLEFIEHYAPSMARYSPDGKHLPGTGYGARLMHYGA---RALDQIERALDILSRD 127 Query: 122 DPDSRRIIVSAWNVGEL--DKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIA 179 D +S+R+++ ++ E + C Q + +G+L + R+ D ++GL ++ Sbjct: 128 DAESKRVVLQIFSADEDLYRRNIDVSCTLGLQLLLREGRLHMVAFMRANDAYVGLLNDVF 187 Query: 180 SYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNH-------MDQTHLQLSREPRPLPKLII 232 S+ L +A + D E+G + G H+Y ++ +D + Q+ P P++ Sbjct: 188 SFTFLQEYVATRLDCEIGAYSHHVGSIHVYDDNLPRALALLDDSDAQIVTAAAP-PRMPA 246 Query: 233 KRKPESI 239 P +I Sbjct: 247 GTSPATI 253 >UniRef50_Q2FCV1 Thymidylate synthase n=2 Tax=Acinetobacter baumannii RepID=Q2FCV1_ACIBA Length = 222 Score = 157 bits (398), Expect = 3e-37, Method: Composition-based stats. Identities = 43/211 (20%), Positives = 83/211 (39%), Gaps = 18/211 (8%) Query: 11 VLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIA 70 +L+ G G + + ++ R L S I E W+L G ++ Sbjct: 19 ILENGDHITASKGEN-FEVRNAVLTLENPRSRLSISETRSKLISCIGEFFWYLNGSDSLE 77 Query: 71 YLHEN---NVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRR 127 ++ + DEN YG + +Q ++ LK+ P SRR Sbjct: 78 FIEYYISDYRKYIEYQIDENKPALGAYGPRIFGAQ-------NQFNKIIEVLKDKPTSRR 130 Query: 128 IIVSAWNVGEL--DKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLV 185 ++S ++ +L + PC QF++ + +L RS D +GL +I S+ L+ Sbjct: 131 AVISIYSKDDLLREDSRDIPCTCLLQFFIRNERLHLTATMRSNDAAIGLVHDIFSFTLIQ 190 Query: 186 HMMAQQC-----DLEVGDFVWTGGDTHLYSN 211 ++ + +L++G++ G H+Y Sbjct: 191 ELLLAKLIRYIPNLQLGEYTHIVGSLHIYKK 221 >UniRef50_B2ZYD3 Deoxyuridylate hydroxymethyltransferase n=1 Tax=Ralstonia phage RSL1 RepID=B2ZYD3_9CAUD Length = 414 Score = 156 bits (394), Expect = 8e-37, Method: Composition-based stats. Identities = 42/222 (18%), Positives = 82/222 (36%), Gaps = 26/222 (11%) Query: 8 MQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLV-TTKRCHLRSIIHELLWFLQGD 66 ++ + G + + R G + + + + E LW L G Sbjct: 59 LETICTVGLKTDSRNGPVIRFPTPVTSVYTHPRQRVSFDAVRDANPFLHLMEALWMLAGR 118 Query: 67 TNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSR 126 ++ + + E+ D+ L YG +WR DQ+ ++++LK +P SR Sbjct: 119 NDVEFASYYAKQML-EYTDDGSTLNGAYGFRWRQ-----HFGYDQLNAIIDELKKNPASR 172 Query: 127 RIIVSAWNVGEL------------------DKMALAPCHAFFQFYVADGKLSCQLYQRSC 168 R ++ W+ PC+ F GKL+ + RS Sbjct: 173 RCVLQMWDASREFYSREDSWAVRRESDLLNQGSKDLPCNTSVMFDAQLGKLNMTVTNRSN 232 Query: 169 DVFLG-LPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLY 209 D+ G N+ +++L +A++C L +G + + H+Y Sbjct: 233 DMIWGCYGANVVHFSMLHEYVAEKCGLPLGHYYQVSNNLHVY 274 >UniRef50_Q5DN81 Thymidylate synthase n=3 Tax=unclassified Siphoviridae RepID=Q5DN81_9CAUD Length = 350 Score = 152 bits (385), Expect = 9e-36, Method: Composition-based stats. Identities = 46/222 (20%), Positives = 95/222 (42%), Gaps = 14/222 (6%) Query: 8 MQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVT-TKRCHLRSIIHELLWFLQGD 66 + + + G + R G ++ + L + + + + E LW L G Sbjct: 17 LAYLRESGLTRETRNGGAVVAPEPVTTVYEQPRERVLFSKLRDANPFFHLFEALWMLAGR 76 Query: 67 TNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSR 126 ++A++ + + ++D+ + YG +WR + DQ++ +++L+ P+ R Sbjct: 77 HDLAFVEKFAKNM-RSFSDDGETMWGAYGWRWRTF-----FDFDQLSWAVHRLRRLPNDR 130 Query: 127 RIIVSAWNVGELDKMAL-----APCHAFFQFYVAD-GKLSCQLYQRSCDVFLG-LPFNIA 179 R++V W G + A PC+ F + D G+L ++ RS D+ G N+ Sbjct: 131 RVVVQMWAAGLDQERADAGGKDVPCNIAIHFRINDRGQLDMTVWNRSNDIIWGAYGANVV 190 Query: 180 SYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLS 221 ++L +A +EVG + D H YS+ ++ +S Sbjct: 191 HMSILQEYVASAVGVEVGRYWQVSDDYHAYSDLFNKMLPLMS 232 >UniRef50_Q21ZJ9 Thymidylate synthase n=1 Tax=Rhodoferax ferrireducens T118 RepID=Q21ZJ9_RHOFD Length = 347 Score = 151 bits (383), Expect = 2e-35, Method: Composition-based stats. Identities = 45/189 (23%), Positives = 75/189 (39%), Gaps = 13/189 (6%) Query: 37 NLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGK 96 + + + L + I E++W L G +L+ N + ++A G YG Sbjct: 48 DPRQRWVLSRRPAINPAFAIAEVIWILLGSDASNFLNFWNP-VLPKYAGSGGTYHGAYGA 106 Query: 97 QWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNV-GELDKMA------LAPCHAF 149 + R +DQI V L +P+SR+ ++ W+ +L PC+ Sbjct: 107 RLR-----THFGLDQIERVYQILSANPESRQAVLQIWDSREDLPLSDGASRDLDIPCNLV 161 Query: 150 FQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLY 209 V KL RS DVFLG P N+ + L ++A + +G F HLY Sbjct: 162 GMLKVRAQKLEWLQIMRSNDVFLGTPHNLVQFTSLQEIIAGWLGIGIGSFSLVTDSLHLY 221 Query: 210 SNHMDQTHL 218 + D+ + Sbjct: 222 EHDYDRCSM 230 >UniRef50_C9DGK1 Deoxyuridylate hydroxymethyltransferase n=1 Tax=Deftia phage phiW-14 RepID=C9DGK1_9CAUD Length = 357 Score = 151 bits (383), Expect = 2e-35, Method: Composition-based stats. Identities = 48/232 (20%), Positives = 86/232 (37%), Gaps = 27/232 (11%) Query: 14 EGTQKNDRTGTGTLSIFGHQMRFNLQDGF---PLVTTKRCHLRSIIHELLWFLQGDTNIA 70 G K R G T F ++F++ D + ++ ++ ++ E W + G NI Sbjct: 26 TGQYKECRNGGST---FLRNVKFHITDPRNRNLTLNGRKSNIFQMVAETFWVMSGSGNIK 82 Query: 71 YLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIV 130 E + +++D+ G W P +Q+ + ++ L D D+RR V Sbjct: 83 EFLEFFLPRAPQYSDD--------GINWHGAYGPRMYAHNQLQSAIDLLIKDKDTRRAYV 134 Query: 131 SAWNVGELDKMA------------LAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLP-FN 177 + A PC+ + + KL ++ QRS D+ G N Sbjct: 135 MIADPTLDSAPAIEAAYGVGHSPKDVPCNREIHINIIEDKLCMKVIQRSGDMLFGTGSIN 194 Query: 178 IASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPK 229 + L ++++ +GD+ W D H Y DQ + L E P Sbjct: 195 PFEFTFLQELLSEATGYALGDYQWDVTDAHYYKAFEDQVNDVLRSEQTFWPN 246 >UniRef50_B2TJD1 Thymidylate synthase n=1 Tax=Clostridium botulinum B str. Eklund 17B RepID=B2TJD1_CLOBB Length = 333 Score = 151 bits (381), Expect = 3e-35, Method: Composition-based stats. Identities = 47/214 (21%), Positives = 90/214 (42%), Gaps = 14/214 (6%) Query: 39 QDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQW 98 Q + + + EL+W + G+ ++ N ++ +++A YGK+ Sbjct: 49 QQKWIYNRIPPISIGYALAELVWIINGEEKSDIINMWNPSL-EKYAGRGDIYHGAYGKRI 107 Query: 99 RAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGE-------LDKMALAPCHAFFQ 151 R DQI L+N P+SR++++ ++ + + PC+ Sbjct: 108 R-----SHFGFDQIEKAYEALQNTPESRQVVIQIYDTKVDFPIEKGIPQDEDIPCNICSL 162 Query: 152 FYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSN 211 V +GKL RS DV LG+P+N + L ++A +L++G + HLY+ Sbjct: 163 LKVRNGKLEWSQIMRSNDVLLGMPYNFIQFTGLQEILAGWLELDLGSYNHYSDSLHLYAR 222 Query: 212 HMDQTHLQLSREPRPLPKLIIKR-KPESIFDYRF 244 +++ + E R L + R + E +F F Sbjct: 223 DINKIGIGQEVEIRNNDSLSLSRNESERLFQEIF 256 >UniRef50_C9KVG6 Thymidylate synthase n=14 Tax=Bacteroidales RepID=C9KVG6_9BACE Length = 233 Score = 144 bits (364), Expect = 3e-33, Method: Composition-based stats. Identities = 52/221 (23%), Positives = 97/221 (43%), Gaps = 20/221 (9%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL 60 M +Y + + K+L G + +R G + ++ D + + + + EL Sbjct: 22 MNKYYQTLDKILQTGKIQTNRKG-RIKYLLNERLMLTPADLLDIFESHGIARKKLKEELK 80 Query: 61 WFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLK 120 F+QG ++ E +T WD + P Y ++ + + T +N+ K Sbjct: 81 LFMQGVRDVEKYKEAGITWWDYCGHTLVNSYPTYFEK-----------LPPLITRINREK 129 Query: 121 NDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIAS 180 + + + + V + APC + QF + +G+L YQRS D LGLP +I Sbjct: 130 RNSKNYVLFLGETGV----ESNQAPCLSLVQFQIDEGELVLSAYQRSSDANLGLPADIYH 185 Query: 181 YALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLS 221 +++MA+Q +L + G+ H+Y N++D+T LS Sbjct: 186 ----LYLMARQVELPLKSITLDLGNVHIYENNIDRTLELLS 222 >UniRef50_C8XUG3 Putative thymidylate synthase n=1 Tax=Shigella phage phiSboM-AG3 RepID=C8XUG3_9CAUD Length = 348 Score = 143 bits (360), Expect = 8e-33, Method: Composition-based stats. Identities = 45/196 (22%), Positives = 87/196 (44%), Gaps = 23/196 (11%) Query: 37 NLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGK 96 +++D + V + + I E W L G +I +L + ++D+ G Sbjct: 50 DIRDRWLSVEGRNSSAIAAIGETFWVLSGRNDIKFLSRVLPRAAN-FSDD--------GV 100 Query: 97 QWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALA------------ 144 WRA P Q+ +V+N+L+ +P++R+ ++ ++ LA Sbjct: 101 TWRAAYGPRLYAHGQLDSVINRLRKNPNTRQAYLTIYDPALDSDAGLAKFSESGEAKTKD 160 Query: 145 -PCHAFFQFYVADGKLSCQLYQRSCDVFLGL-PFNIASYALLVHMMAQQCDLEVGDFVWT 202 C+ F + DG+L+ + RS DV G+ N +++L ++AQ D++VG + Sbjct: 161 MVCNLALLFAIVDGRLNLTVINRSQDVLWGMSSINFIEFSILQEVIAQVLDVDVGQYKLF 220 Query: 203 GGDTHLYSNHMDQTHL 218 + H Y+N + Q L Sbjct: 221 SNNLHYYNNEVSQKQL 236 >UniRef50_Q46E28 Putative thymidylate synthase n=5 Tax=Methanosarcinales RepID=TYSY_METBF Length = 217 Score = 137 bits (345), Expect = 4e-31, Method: Composition-based stats. Identities = 41/167 (24%), Positives = 62/167 (37%), Gaps = 12/167 (7%) Query: 55 IIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITT 114 I HE W N L E + + D YG++ R W +DQI Sbjct: 60 IPHETAW------NEERLEEYAKQLI--SGENTQDFEYTYGQRLRNWH----GKVDQIDY 107 Query: 115 VLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGL 174 V+ +L+ +P SRR I W K+ PC F + DGK+ RS D Sbjct: 108 VIEKLQQNPTSRRAIAVTWIPPVDTKVNEVPCMMLDDFKIRDGKIHLTTLFRSHDFGGAY 167 Query: 175 PFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLS 221 P N+ + L+ +A + + G H+Y + D + Sbjct: 168 PANLYGLSKLLEYVADKVGTKPGTITTISISAHIYDHDWDMVENIVK 214 >UniRef50_P18029 Deoxycytidylate 5-hydroxymethyltransferase n=10 Tax=T4-like viruses RepID=DCHM_BPT2 Length = 246 Score = 135 bits (341), Expect = 1e-30, Method: Composition-based stats. Identities = 50/214 (23%), Positives = 80/214 (37%), Gaps = 22/214 (10%) Query: 12 LDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAY 71 L E D+TG T+ I G F + F +++ EL W+ + Sbjct: 19 LKEKDFVVDKTGVKTIEIIGA--SFVADEPFIFGALNDEYIQ---RELEWYKSKSLFVKD 73 Query: 72 LHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIV- 130 + IW + A G++ YG W W + D L +L +PDSRR I+ Sbjct: 74 IPGETPKIWQQVASSKGEINSNYG--WAIWSEDNYAQYDM---CLAELGQNPDSRRGIMI 128 Query: 131 ----SAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVH 186 S D M+ C Q+ + D K++ + RS DV G + A ++ Sbjct: 129 YTRPSMQFDYNKDGMSDFMCTNTVQYLIRDKKINAVVNMRSNDVVFGFRNDYAWQKYVLD 188 Query: 187 MMAQQCD-------LEVGDFVWTGGDTHLYSNHM 213 + + + G +W G H+YS H Sbjct: 189 KLVSDLNAGDSTRQYKAGSIIWNVGSLHVYSRHF 222 >UniRef50_C5U4L9 Thymidylate synthase, methanogen type n=1 Tax=Methanocaldococcus infernus ME RepID=C5U4L9_9EURY Length = 212 Score = 133 bits (334), Expect = 7e-30, Method: Composition-based stats. Identities = 45/225 (20%), Positives = 91/225 (40%), Gaps = 30/225 (13%) Query: 2 KQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPL---VTTKRCHLRSIIHE 58 K Y L++++L++G++ G + ++ + + + S + Sbjct: 10 KAYEILVKEILEKGSEMITEDGQRCKELLNVFVKITNPKLKSISSKYPLGKNAIESYKKQ 69 Query: 59 LLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGR-HIDQITTVLN 117 L L+G N + Y ++ R +P+ D + DQ++ V+ Sbjct: 70 L---LEGSQN--------------------NFTYNYYERIREYPSYDRKLKNDQLSYVIE 106 Query: 118 QLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFN 177 +LKN+ SRR ++S W K+ PC F + + KL + RS D+ L N Sbjct: 107 KLKNNSTSRRAVISLWQPFIDQKVKDVPCLQHIGFQLREDKLIMSVLFRSNDILLAFHSN 166 Query: 178 IASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSR 222 L ++A+ ++E+ ++ + H+Y +D+ L R Sbjct: 167 ALGLISLGELVAKSLEVELKEYNHFIYNAHIY---IDRDKDYLRR 208 >UniRef50_Q8MW00 Bifunctional dihydrofolate reductase-thymidylate synthase (Fragment) n=1 Tax=Amastigomonas debruynei RepID=Q8MW00_9EUKA Length = 259 Score = 128 bits (323), Expect = 1e-28, Method: Composition-based stats. Identities = 49/112 (43%), Positives = 67/112 (59%), Gaps = 12/112 (10%) Query: 4 YLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFL 63 YL+L+++VL +G +++DRTG GT S+FG ++ F+L DGFPL+TTKR R + ELLWF+ Sbjct: 148 YLDLIRRVLADGFERDDRTGVGTFSLFGEKLEFDLGDGFPLLTTKRVFWRGVAEELLWFV 207 Query: 64 QGDTNIAYLHENNVTIWDEWADEN------------GDLGPVYGKQWRAWPT 103 G TN L + IWD + GDLGPVYG QW + Sbjct: 208 SGSTNANELAAKGIRIWDGNSSREYLDSIGLTEREVGDLGPVYGFQWSHFGA 259 >UniRef50_Q8MVZ8 Bifunctional dihydrofolate reductase-thymidylate synthase (Fragment) n=1 Tax=Chlamydaster sterni RepID=Q8MVZ8_9EUKA Length = 260 Score = 128 bits (323), Expect = 1e-28, Method: Composition-based stats. Identities = 54/115 (46%), Positives = 72/115 (62%), Gaps = 13/115 (11%) Query: 2 KQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDG-FPLVTTKRCHLRSIIHELL 60 KQYL+L+ +++ GTQ+ DRTGTGTLSIFG QMRF+ +D PL+TTK+ R + E+L Sbjct: 146 KQYLDLVDRIITSGTQRGDRTGTGTLSIFGTQMRFSPRDDTLPLLTTKKVFWRGVAEEML 205 Query: 61 WFLQGDTNIAYLHENNVTIWDEWAD------------ENGDLGPVYGKQWRAWPT 103 WF++G T+ L + IWD+ A E GDLGPVYG QWR + Sbjct: 206 WFMKGCTDARVLSAKKIHIWDDNASRKFLDENGLSHREEGDLGPVYGFQWRHFGA 260 >UniRef50_Q7Y590 Putative uncharacterized protein RB69ORF048c n=3 Tax=unclassified T4-like viruses RepID=Q7Y590_BPR69 Length = 238 Score = 128 bits (323), Expect = 2e-28, Method: Composition-based stats. Identities = 44/223 (19%), Positives = 81/223 (36%), Gaps = 26/223 (11%) Query: 9 QKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLW--FLQGD 66 +++L+ D I + + F + + + E W + G Sbjct: 24 REILENPEFVTDSRIGRCNEIGSMTVVVDTPSSFKMTDPRINRISYEYAEDFWKFMISGG 83 Query: 67 TNIAYLHENNVTIWDEWADENGD-----LGPVYGKQWRAWPTPDGRHIDQITTVLNQLKN 121 T+ + + + D YG + A Q+ +L +LK Sbjct: 84 TDAEEAFKAYPNVAKFISKPKSDALPANFNTFYGPRIAA----------QLPALLKELKE 133 Query: 122 DPDSRRIIVSAWNVGE-----LDKMALAPCHAFFQFYVADGKL--SCQLYQRSCDVFLGL 174 P+SRR++ + D+ PC +Y+ DGKL C + ++C V + L Sbjct: 134 KPNSRRVVFQILESSDQALLDSDETLEYPCTDSVTYYIRDGKLYTHCHMRSQNCAVVMQL 193 Query: 175 PFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTH 217 F + L+H +A +C +EVGD+ T H++ D Sbjct: 194 DFYLQ--GKLLHYIANECGVEVGDYTHTMVSAHVFERDFDYVK 234 >UniRef50_Q8MVZ6 Bifunctional dihydrofolate reductase-thymidylate synthase (Fragment) n=1 Tax=Diplonema ambulator RepID=Q8MVZ6_9EUGL Length = 255 Score = 128 bits (321), Expect = 3e-28, Method: Composition-based stats. Identities = 48/115 (41%), Positives = 64/115 (55%), Gaps = 13/115 (11%) Query: 2 KQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDG-FPLVTTKRCHLRSIIHELL 60 +QYL+L+ ++ G K DRTG GT+S FG QMRF+L+DG PL+TTKR + + EL Sbjct: 141 QQYLDLVDDIIKNGFTKGDRTGVGTISKFGAQMRFSLRDGVIPLLTTKRVFWKGVAEELF 200 Query: 61 WFLQGDTNIAYLHENNVTIWDEWADE------------NGDLGPVYGKQWRAWPT 103 WF++G TN L + V IWD DLGP+YG QW + Sbjct: 201 WFIKGCTNGKDLKDKGVHIWDGNGTRAFLDSRGLPDRAEDDLGPIYGLQWSHFGA 255 >UniRef50_B8GIB9 Thymidylate synthase, methanogen type n=1 Tax=Methanosphaerula palustris E1-9c RepID=B8GIB9_METPE Length = 244 Score = 127 bits (319), Expect = 4e-28, Method: Composition-based stats. Identities = 43/227 (18%), Positives = 79/227 (34%), Gaps = 25/227 (11%) Query: 8 MQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDT 67 ++ VL++G G T+ ++ P+++T G Sbjct: 17 VKTVLEKGWVLGTEDGEATIECEELALQVENPTTEPMIST-----------------GSR 59 Query: 68 NIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGR-----HIDQITTVLNQLKND 122 E D +G Y + W +DQI ++ +L+ Sbjct: 60 FQRRFMEKYA--ADLLHGSDGIFEYDYHGRLFNWGDRLAADEAPVQVDQIAYIIRKLQEA 117 Query: 123 PDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYA 182 P +RR + WN +++ PC Q + DG L ++ RS D+ N+ + Sbjct: 118 PATRRALAITWNPVVDEQVKDCPCLQLVQCVIRDGALQMKVVFRSNDMLTASGANMFALV 177 Query: 183 LLVHMMAQQCDLEVGDFVWTGGDTHLY-SNHMDQTHLQLSREPRPLP 228 L M+A+ + +G + H+Y + MD +R R P Sbjct: 178 HLQLMIAEALGVRIGRYTHIALVPHVYFTRDMDDLKAFCNRGERFHP 224 >UniRef50_O26868 Putative thymidylate synthase n=2 Tax=Methanothermobacter RepID=TYSY_METTH Length = 222 Score = 127 bits (319), Expect = 5e-28, Method: Composition-based stats. Identities = 47/219 (21%), Positives = 84/219 (38%), Gaps = 14/219 (6%) Query: 5 LELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFN--LQDGFPLVTTKRCHLRSIIHELLWF 62 +L++K++ +G + D G+ T + + L +R L +I +F Sbjct: 15 KKLVEKIMHDGREIRDERGSLTREVMNTVVTIKKPLGKSDDFYHIRRGSLLNIKVPEGYF 74 Query: 63 LQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKND 122 G+ + E ++ D G + YG + RA +DQ+ + +LKN Sbjct: 75 WSGE-KLEKYSEQFLS-----GDRKGFV-YTYGNRLRA-----HFGVDQLDEAIRRLKNC 122 Query: 123 PDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYA 182 +SRR + W+ E PC F + DG+L RS D++ N A Sbjct: 123 TESRRATMVTWDPPEDTASDEVPCMILVDFKIRDGRLFTTALWRSHDIYGAWFPNAVGLA 182 Query: 183 LLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLS 221 L +A + +EVG H+Y + + + Sbjct: 183 YLADHVAAEVGVEVGHITIHSISAHIYEVNFKEAEEVIK 221 >UniRef50_B3QQU8 Thymidylate synthase n=1 Tax=Chlorobaculum parvum NCIB 8327 RepID=B3QQU8_CHLP8 Length = 343 Score = 125 bits (314), Expect = 2e-27, Method: Composition-based stats. Identities = 45/262 (17%), Positives = 90/262 (34%), Gaps = 32/262 (12%) Query: 11 VLDEGTQKNDRTGTGTLSIFGHQMR--FNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTN 68 ++ EG ++ R G + + M N V +R + E LW G + Sbjct: 20 LIKEGVKRKTR-GKLCIELPKPFMFKITNPTARLVTVPERRWNPILPFAESLWLATGKND 78 Query: 69 IAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRH-----------------IDQ 111 + ++ + ++D+ L YG + R + + + +DQ Sbjct: 79 LEFIGHYLKNM-KNFSDDGEFLRGGYGPRLRKYNGINDDYKIRNTYDIDIAKLNKSEVDQ 137 Query: 112 ITTVLNQLKNDPDSRRIIVSAWNV--------GELDKMALAPCHAFFQFYV--ADGKLSC 161 + + D +R+ I++ + G L PC F KL+ Sbjct: 138 FGFICKSFEKDKFTRQAIINIGDPPKDCFDKKGNLKITKDFPCTRLLHFQKQPKANKLNL 197 Query: 162 QLYQRSCDVFLGLPF-NIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQL 220 +Y RS D G NI ++ ++ +Q DLE+G++ + H Y D Sbjct: 198 TVYMRSNDFVWGASAVNIFNFTFMLEYFSQILDLEIGEYYHIANNFHYYEEFEDLVQSIS 257 Query: 221 SREPRPLPKLIIKRKPESIFDY 242 + K + ++ ++ Sbjct: 258 RTKTVEESKFEYSKSFHNLSEF 279 >UniRef50_Q57931 Putative thymidylate synthase n=11 Tax=Methanococcales RepID=TYSY_METJA Length = 222 Score = 123 bits (308), Expect = 8e-27, Method: Composition-based stats. Identities = 42/221 (19%), Positives = 74/221 (33%), Gaps = 27/221 (12%) Query: 4 YLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFL 63 + EL+ K+L +G T I + K+ + + E Sbjct: 13 FNELIPKILKDGEVVETEFEERTKEIRNTIIEITNPK------LKKVPEKYPLGE----- 61 Query: 64 QGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDP 123 + E + + +N Y ++ +P D + I+QI ++ +L Sbjct: 62 ------KAVEEYTKNLL--YGSKNV-FSYDYHQRLFEYPYADEK-INQIDYIIEKLNQQK 111 Query: 124 DSRRIIVSAWNVGEL-----DKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNI 178 +SRR + WN D+ PC QF + +GKL + RS D L N Sbjct: 112 NSRRAVAITWNPKIDIEVSRDERGSVPCLQLVQFLIRNGKLYQTVIFRSNDALLAFVSNA 171 Query: 179 ASYALLVHMMAQQCDLEVGDFVWTGGDTHLY-SNHMDQTHL 218 L +A++ + G + H+Y D Sbjct: 172 IGLITLGEYIAKKVGVGYGTYTHHAISMHIYVDRDFDYIKK 212 >UniRef50_Q8MVZ5 Bifunctional dihydrofolate reductase-thymidylate synthase (Fragment) n=1 Tax=Tetrahymena sp. RepID=Q8MVZ5_9HYMN Length = 311 Score = 123 bits (308), Expect = 8e-27, Method: Composition-based stats. Identities = 57/114 (50%), Positives = 69/114 (60%), Gaps = 13/114 (11%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDG-FPLVTTKRCHLRSIIHELLW 61 QYL+L+Q+V+ G + DRTGTGTLSIFG MRF+L G FPL+TTK+ LR I EL W Sbjct: 198 QYLDLVQRVVSTGVSRGDRTGTGTLSIFGAMMRFDLSSGAFPLLTTKKTFLRGIAEELFW 257 Query: 62 FLQGDTNIAYLHENNVTIWDEWADE------------NGDLGPVYGKQWRAWPT 103 FL+GDT+ L +V IWD A GDLGPVYG QW + Sbjct: 258 FLKGDTSQTRLAAKDVHIWDANATRAFLDARGLPDRPEGDLGPVYGCQWSHFGA 311 >UniRef50_Q52PP0 Putative thymidylate synthase n=1 Tax=Xanthomonas phage Xp15 RepID=Q52PP0_9CAUD Length = 273 Score = 120 bits (302), Expect = 5e-26, Method: Composition-based stats. Identities = 49/237 (20%), Positives = 91/237 (38%), Gaps = 16/237 (6%) Query: 6 ELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQG 65 +LM + +G R G + Q+ F ++ + E+ W L G Sbjct: 13 DLMLRTFTQGFVSKPR-GMEIRELLNAQVTVQTFVPFQCWPDRKYDIGYFKKEMRWKL-G 70 Query: 66 DTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDS 125 + + + +W+ + +G YG+ W G+ + + V+ +L D DS Sbjct: 71 ASKFDDSIKQHAKMWESVQNPDGTFNSNYGQFWF------GQQMG-VMKVVMELIRDQDS 123 Query: 126 RRIIVSAWNVGEL-DKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALL 184 RR I+ L + C F++ L ++ RS D GL +I ++++L Sbjct: 124 RRAIIPMLTDDHLSPETVDTVCTEAVSFHIRHNTLYTSVHMRSSDQIFGLGTDIPTFSVL 183 Query: 185 VHMM-----AQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSR-EPRPLPKLIIKRK 235 H++ A L+VG T +H+Y H L E P +++I + Sbjct: 184 THLVHGLLQANYPSLQVGSMTITAASSHIYERHYRMVDKILDNLEDIPDSEIVILPQ 240 >UniRef50_A3CSY2 Thymidylate synthase n=3 Tax=Methanomicrobiales RepID=A3CSY2_METMJ Length = 241 Score = 118 bits (296), Expect = 2e-25, Method: Composition-based stats. Identities = 28/131 (21%), Positives = 52/131 (39%), Gaps = 5/131 (3%) Query: 86 ENGDLGPVYGKQWRAWPTP-----DGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDK 140 + Y ++ W + H+DQI + +L+ +SRR + WN + Sbjct: 76 SDAKFEYDYHRRLFDWGEQLMVNGEDVHVDQIDYIARKLEQAANSRRAVAVTWNPVVDEN 135 Query: 141 MALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFV 200 + PC Q + +GKL ++ RS D+ N+ + L M+A + + G + Sbjct: 136 LDDCPCLQLVQCLLRNGKLQMKVVFRSNDILSAAGSNMYALVRLQKMIADRLGVPCGRYT 195 Query: 201 WTGGDTHLYSN 211 H+Y Sbjct: 196 HIALVPHIYYR 206 >UniRef50_UPI0001C33797 thymidylate synthase n=3 Tax=Cyanobacteria RepID=UPI0001C33797 Length = 504 Score = 117 bits (294), Expect = 3e-25, Method: Composition-based stats. Identities = 39/160 (24%), Positives = 69/160 (43%), Gaps = 12/160 (7%) Query: 70 AYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRII 129 ++++ I D+ + G + YG++ R+W DQI V++ L +D +S R + Sbjct: 254 EFINDYISQILDDSSQREG-IKYTYGQRLRSWFKK-----DQIQQVIDLLVSDINSSRAV 307 Query: 130 VSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLV-HMM 188 +S W+V + D PC D +LS RS D+F P N L H+M Sbjct: 308 MSLWDVNDYDNNDSPPCLNHIWIRTIDDELSLTATFRSNDMFSAWPSNAMGLRALQIHIM 367 Query: 189 AQQCD-----LEVGDFVWTGGDTHLYSNHMDQTHLQLSRE 223 + + L++G V H+Y++ + + E Sbjct: 368 REIQNRINQKLKIGPLVTVSQSAHIYNDCWEYADKIVDAE 407 >UniRef50_B7KFY9 Thymidylate synthase n=11 Tax=Cyanobacteria RepID=B7KFY9_CYAP7 Length = 512 Score = 109 bits (274), Expect = 7e-23, Method: Composition-based stats. Identities = 37/157 (23%), Positives = 65/157 (41%), Gaps = 12/157 (7%) Query: 70 AYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRII 129 L + + + + G + YGK+ R+W DQI V+ +L D +S R + Sbjct: 254 QNLQNYIEQMLSDLSSQEG-VEYTYGKRLRSWFKQ-----DQIEQVIKKLTLDINSSRAV 307 Query: 130 VSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFN-IASYALLVHMM 188 +S W+V + + PC V + +LS RS D+F P N + AL H++ Sbjct: 308 MSLWDVHDHEGNDNPPCLNHIWLRVVENELSLTATFRSNDMFSAWPANAMGLRALQQHIL 367 Query: 189 AQQ-----CDLEVGDFVWTGGDTHLYSNHMDQTHLQL 220 L++G + H+YS+ + + Sbjct: 368 DNINQRASYSLKMGPLITVSQSAHIYSDCWEYADRLI 404 >UniRef50_Q2NEY9 ThyA n=1 Tax=Methanosphaera stadtmanae DSM 3091 RepID=Q2NEY9_METST Length = 209 Score = 108 bits (270), Expect = 2e-22, Method: Composition-based stats. Identities = 46/224 (20%), Positives = 81/224 (36%), Gaps = 30/224 (13%) Query: 2 KQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCH---LRSIIHE 58 + +L ++K++ EG + D G+ T + + + + H L + E Sbjct: 12 QAWLTCVKKIMQEGHEVTDERGSLTKELQNVILEITNPNDNTIPECSPWHDDRLETYKKE 71 Query: 59 LLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQ 118 LL D YG + R + IDQI T + + Sbjct: 72 LL----------------------DPDNEQGFVYTYGNRLRQY-----FKIDQIDTCIEK 104 Query: 119 LKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNI 178 L N P SRR I + + +K+ PC F + D +L + RS D N+ Sbjct: 105 LNNCPQSRRAIAITIDPIQDNKVDEIPCLQEIAFLIRDNQLYMTDFFRSNDCGGATFPNL 164 Query: 179 ASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSR 222 + + +A+ D E+ + V H+Y + D+ L + Sbjct: 165 FGIREVGYYVAKNTDTELVNMVHHAMSLHIYEHDWDKCREILRK 208 >UniRef50_O28232 Thymidylate synthase, putative n=2 Tax=Archaeoglobaceae RepID=O28232_ARCFU Length = 480 Score = 100 bits (249), Expect = 6e-20, Method: Composition-based stats. Identities = 31/129 (24%), Positives = 52/129 (40%), Gaps = 2/129 (1%) Query: 92 PVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQ 151 Y ++ R + D +DQ+ V+ +LK D R V +L PC +Q Sbjct: 339 YTYAERAR-YCDRDDVKVDQLYKVIEKLKEDSCRRDCYVGISRPWDL-LSDEPPCLRGYQ 396 Query: 152 FYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSN 211 F +L Y RS D + + N+ ++ALL +A+ + + D H+Y+ Sbjct: 397 FSKYGDELLGTFYMRSNDAYGAMHANMYAFALLTKYVAELTGFKSYRYNHFALDAHIYAE 456 Query: 212 HMDQTHLQL 220 D L Sbjct: 457 FFDAVREIL 465 Score = 50.3 bits (119), Expect = 6e-05, Method: Composition-based stats. Identities = 15/105 (14%), Positives = 35/105 (33%), Gaps = 2/105 (1%) Query: 112 ITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVF 171 + + +L+ P +RR + W + + P ++ KL + RS + Sbjct: 122 VESAAEKLRKSPHTRRASIPLWYPKDH--LCRNPAAITEISFIFHEKLHLTAFLRSMECL 179 Query: 172 LGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQT 216 N + + ++ +E G H Y +++ Sbjct: 180 SYFEHNFDFLVEALETICRKTGMEEGSIGMLIAVPHFYERDVERA 224 >UniRef50_Q8TVL9 Putative thymidylate synthase n=1 Tax=Methanopyrus kandleri RepID=TYSY_METKA Length = 209 Score = 94.2 bits (233), Expect = 4e-18, Method: Composition-based stats. Identities = 28/128 (21%), Positives = 47/128 (36%), Gaps = 6/128 (4%) Query: 90 LGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAF 149 YG + R + +DQ+T ++ +L ++RR I W+ PC Sbjct: 86 FEYTYGHRLRRY-----FGLDQVTKIVERLSESNNTRRAIAVTWDPRRDLDEEEVPCLTA 140 Query: 150 FQFYVADG-KLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHL 208 Q G L + RS DV L N+ + L +A++ LE + H+ Sbjct: 141 LQLQSDGGSGLELHAFYRSWDVGKALVANMIALRRLQEHVAERAGLEPTTLTVYAANAHV 200 Query: 209 YSNHMDQT 216 Y + Sbjct: 201 YEEDLPDL 208 >UniRef50_Q2FKU7 Thymidylate synthase-like n=1 Tax=Methanospirillum hungatei JF-1 RepID=Q2FKU7_METHJ Length = 285 Score = 89.9 bits (222), Expect = 8e-17, Method: Composition-based stats. Identities = 48/232 (20%), Positives = 82/232 (35%), Gaps = 45/232 (19%) Query: 2 KQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLW 61 +QY + + T + D GT + +G+++R + +V+ ++ I L Sbjct: 69 EQYQASLYTI----TPRRD-DGTDAVYTYGNRLRDYPKAEVGIVSKHGGAVKKAIDALF- 122 Query: 62 FLQGDTNIAYLHENNVT--IWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQIT-TVLNQ 118 + Y+ + IW +G G IDQI +++N+ Sbjct: 123 -----RKLGYVPADACGELIWK----GDGRYG----------------GIDQIQESIINR 157 Query: 119 LKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYV-ADGKLSCQLYQRSCDVFLGLPFN 177 L +P+SRR I W + PC Q + + L+ RS D+ N Sbjct: 158 LIQNPESRRAISITWFPVQDITADEPPCLQLVQCVIDKNNHLNLICVFRSNDMLSAWGQN 217 Query: 178 IASYALLVHMMAQQCDLE---------VGDFVWTGGDTHLYSNHMDQTHLQL 220 A L + +Q +L+ G H+Y H DQ L L Sbjct: 218 AYGLAHLQKFICEQINLKRKNAEEKVSQGWLETISISAHMYF-HRDQLELNL 268 >UniRef50_A1RYR8 Thymidylate synthase-like protein n=1 Tax=Thermofilum pendens Hrk 5 RepID=A1RYR8_THEPD Length = 460 Score = 88.4 bits (218), Expect = 2e-16, Method: Composition-based stats. Identities = 26/142 (18%), Positives = 48/142 (33%), Gaps = 10/142 (7%) Query: 92 PVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQ 151 YG + R DQ+ ++ +L + PD+RR I W+ PC Q Sbjct: 240 YSYGDRLRRHREAG----DQVRRIVERLASSPDTRRAIALTWDFATDTNSQDPPCLVAVQ 295 Query: 152 FYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCD------LEVGDFVWTGGD 205 ++ + + RS D + P N L+ +A + ++ G V Sbjct: 296 GDLSGDTYNQVAFFRSHDAYAAWPLNAYGLLALMRRVAGELSERTGRAVKPGWLVVYSSS 355 Query: 206 THLYSNHMDQTHLQLSREPRPL 227 H+Y + + + Sbjct: 356 LHVYEHDWGRALRLVQENAAEA 377 >UniRef50_A2E1C8 Putative uncharacterized protein n=1 Tax=Trichomonas vaginalis RepID=A2E1C8_TRIVA Length = 478 Score = 86.1 bits (212), Expect = 1e-15, Method: Composition-based stats. Identities = 43/258 (16%), Positives = 77/258 (29%), Gaps = 36/258 (13%) Query: 5 LELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQ-DGFPLVTTKRCHLRSIIHELLWFL 63 +++ K+++ G K R G + L+ + T + I E L Sbjct: 197 KKVIHKIIEFGEFKK-RNSIGESYYELIDFTYVLEAENRKYETIETTGEVPITDEFL--- 252 Query: 64 QGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDP 123 E + G Y R + + +L+ DP Sbjct: 253 -------------KHYITEIISDKVPPGLSYTYGNRIAR--------HLDATVKKLQTDP 291 Query: 124 DSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYAL 183 +R+ +S W ++ PC F + +L + RS D F L N+ Sbjct: 292 VTRQAHISLWLDQDVSSPN-PPCLTDIDFNLQKNRLFMTCHFRSHDAFAALRSNMYGLVK 350 Query: 184 LVH-MMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDY 242 L +++Q + G V +H+Y +D + P F Sbjct: 351 LQEKVISQLPGVREGPLVLMANSSHIYERDIDTIKRSIVFGP------ECNADKRGYFTV 404 Query: 243 RFED--FEIEGYDPHPGI 258 E+ I YD + Sbjct: 405 AVEEKNIVICHYDYENKL 422 >UniRef50_UPI0001C42129 thymidylate synthase ThyA n=1 Tax=Methanobrevibacter ruminantium M1 RepID=UPI0001C42129 Length = 236 Score = 85.7 bits (211), Expect = 2e-15, Method: Composition-based stats. Identities = 45/229 (19%), Positives = 83/229 (36%), Gaps = 18/229 (7%) Query: 4 YLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLW-- 61 YLE + K+L EG + + G + + D L R + + EL+ Sbjct: 8 YLEFVNKILKEGKETYKDSDHHLKEYLG--NYYYIDDPLDL--KFRAKYQHMTPELMLEE 63 Query: 62 FLQGDTNIA--YLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQL 119 +G +I + + + + + + D G VY R +DQ + ++ Sbjct: 64 IKKGRYDIDACPIKGDALYEYVKSFEIRDDQGFVYTYPNRILEH---FGVDQFEVMKERI 120 Query: 120 KNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIA 179 S R + ++ PC F Q V DG+L+ + RS D+F N+ Sbjct: 121 LTATGSNRAVAVTYDPKLDHDREDIPCLQFVQMLVRDGELTIHVIFRSNDIFGAFYSNMF 180 Query: 180 SYALLVHMMAQQCDLEV-------GDFVWTGGDTHLYSNHMDQTHLQLS 221 + M ++ + E+ G + H+Y+N M +S Sbjct: 181 FICYMGIKMKEEVNKEIMGEKLNFGGIHYHSTSGHIYNNDMRAARKLIS 229 >UniRef50_A5UP11 Predicted thymidylate synthase, ThyA n=2 Tax=Methanobrevibacter smithii RepID=A5UP11_METS3 Length = 232 Score = 85.3 bits (210), Expect = 2e-15, Method: Composition-based stats. Identities = 39/227 (17%), Positives = 82/227 (36%), Gaps = 16/227 (7%) Query: 4 YLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTT-KRCHLRSIIHELLWF 62 YL+ ++K+L++G + + G+ + V + +++E Sbjct: 8 YLDFVKKILNQGKETYKDSNHHLKESLGNFYVIDDPLNLKFVAKYQHMTTDMMLNE---I 64 Query: 63 LQGDTNIA--YLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLK 120 G +I + + + + + + + D G VY R D +DQ + ++ Sbjct: 65 KSGKYDIEGCPIKSDALYEYVKSFENSDDQGFVYTYPNRILAHFD---VDQFEVMKKRML 121 Query: 121 NDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIAS 180 + S R + ++ PC F Q V + +L+ RS D+F N+ Sbjct: 122 HAIGSNRAVAVTYDPKLDQDREDIPCLQFLQCIVRNNELTIHCLFRSNDIFGAFYSNMFF 181 Query: 181 YALLVHMMAQQCDLEV-------GDFVWTGGDTHLYSNHMDQTHLQL 220 + M ++ + E+ G + H+YSN M + Sbjct: 182 ITYIGIKMKEELNKELLGEKVNFGGIHYHSTSGHIYSNDMKAAKKLI 228 >UniRef50_B9PCT2 Predicted protein (Fragment) n=2 Tax=root RepID=B9PCT2_POPTR Length = 57 Score = 84.2 bits (207), Expect = 4e-15, Method: Composition-based stats. Identities = 38/57 (66%), Positives = 50/57 (87%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIH 57 MKQYL+ M+ V + GT+K+DRTGTGT S+FG+QMRF+L +GFP+VTTK+ HL+SIIH Sbjct: 1 MKQYLDFMRHVYEHGTEKSDRTGTGTRSVFGYQMRFDLNEGFPVVTTKKLHLKSIIH 57 >UniRef50_B8KML0 Putative thymidylate synthase n=1 Tax=gamma proteobacterium NOR5-3 RepID=B8KML0_9GAMM Length = 191 Score = 80.7 bits (198), Expect = 5e-14, Method: Composition-based stats. Identities = 28/121 (23%), Positives = 53/121 (43%), Gaps = 2/121 (1%) Query: 104 PDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQL 163 D IDQ ++ +L+N +++ +S G L++ L PC + +GKL+ Q Sbjct: 54 YDMNGIDQFDWMVGRLRNKSETKSAAISLLVPG-LNQANL-PCLCVVDSKIRNGKLNLQF 111 Query: 164 YQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSRE 223 + RS +VF N+ + A L +A ++G H+Y +++ + Sbjct: 112 FFRSQNVFGRQYANLVAIARLQEKLAASVGCDIGILKGYIASAHIYEYDLEEARSLVEGR 171 Query: 224 P 224 P Sbjct: 172 P 172 >UniRef50_D2BHQ5 Thymidylate synthase n=5 Tax=Dehalococcoides RepID=D2BHQ5_DEHSV Length = 217 Score = 80.7 bits (198), Expect = 5e-14, Method: Composition-based stats. Identities = 30/117 (25%), Positives = 47/117 (40%), Gaps = 2/117 (1%) Query: 102 PTPDGRHIDQITTVLNQLKNDP-DSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLS 160 T QI V+ K ++ + ++ N LD PC V GKL Sbjct: 94 YTYGQYLEAQIAKVIKMYKETGFNTNQAFMTVGNPETLDL-EDPPCLRSIDTRVRYGKLH 152 Query: 161 CQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTH 217 +Y RS D++ G P N+A+ +L MA + +E G+ + H+Y D Sbjct: 153 FIIYFRSWDLWAGFPSNLAAIQMLKEYMAAEIGVEDGEIIAMSKGMHIYDYAWDIAK 209 >UniRef50_C7JA78 Os12g0446900 protein (Fragment) n=1 Tax=Oryza sativa Japonica Group RepID=C7JA78_ORYSJ Length = 89 Score = 80.3 bits (197), Expect = 5e-14, Method: Composition-based stats. Identities = 28/43 (65%), Positives = 36/43 (83%) Query: 152 FYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDL 194 FYV +G+LSCQ+YQRS D+ LG+PFNIASY+LL M+AQ C + Sbjct: 33 FYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCGM 75 Score = 47.6 bits (112), Expect = 5e-04, Method: Composition-based stats. Identities = 14/40 (35%), Positives = 20/40 (50%), Gaps = 3/40 (7%) Query: 49 RCHLRSIIHELLWFLQGDTNIAYLHENN---VTIWDEWAD 85 R R ++ ELLWF+ G TN + EN ++ AD Sbjct: 11 RVFWRGVLEELLWFISGSTNAKFYVENGELSCQMYQRSAD 50 >UniRef50_UPI0001742C7A thymidylate synthase n=1 Tax=candidate division TM7 single-cell isolate TM7a RepID=UPI0001742C7A Length = 61 Score = 77.2 bits (189), Expect = 6e-13, Method: Composition-based stats. Identities = 25/63 (39%), Positives = 36/63 (57%), Gaps = 2/63 (3%) Query: 202 TGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAP 261 T D H+Y NH++ QL+R+P L K+ I KP + FED +E Y+ +P IK Sbjct: 1 TIIDAHIYENHIEGLKEQLTRKPLKLAKIKIADKP--FNELTFEDITLEDYESYPAIKFE 58 Query: 262 VAI 264 VA+ Sbjct: 59 VAV 61 >UniRef50_A5KRW4 Thymidylate synthase-like protein n=1 Tax=candidate division TM7 genomosp. GTL1 RepID=A5KRW4_9BACT Length = 208 Score = 77.2 bits (189), Expect = 6e-13, Method: Composition-based stats. Identities = 29/122 (23%), Positives = 52/122 (42%), Gaps = 8/122 (6%) Query: 98 WRAWPTPDGRHIDQITTVLNQLKNDPDSRR--IIVSAWNVGELDKMALAPCHAFFQFYVA 155 RA+ P+ QI ++++L DP S + +S W+ ++PC + Sbjct: 87 HRAFDEPN----SQIEFLISKL--DPQSPKGEAQISMWDKNIDQDQKVSPCTQIIWARIK 140 Query: 156 DGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQ 215 GKL ++ S DV+ L NI + L H +A++ + VG + HL+ + Sbjct: 141 HGKLELHVHAHSSDVYKKLLMNILEFVSLQHYIAERVGVPVGKYYHFLDSGHLHQKDIKA 200 Query: 216 TH 217 Sbjct: 201 IE 202 >UniRef50_B1ZRC5 Thymidylate synthase-like protein n=1 Tax=Opitutus terrae PB90-1 RepID=B1ZRC5_OPITP Length = 295 Score = 76.5 bits (187), Expect = 9e-13, Method: Composition-based stats. Identities = 26/193 (13%), Positives = 69/193 (35%), Gaps = 19/193 (9%) Query: 69 IAYLHENNVTIWDE-WADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRR 127 + +++ T W+ + G + G +++QI V+ +L P +R+ Sbjct: 88 VKNMNDPKDTRWEYTYHGRLAAYGTWQESRDGQPVRVGGFNVNQIEAVIAKLVKQPFTRQ 147 Query: 128 IIVSAWNVGELDKMALAPCHAFFQFYVADGK-----LSCQLYQRSCDVFLGLPFNIASYA 182 + W + PC + + + L+C + RS D + N+ + Sbjct: 148 AQMITWMPNIDLECYDPPCLQSLWYRLMEDDDGVSWLNCNVRFRSNDAWGASFMNMFGFV 207 Query: 183 -----LLVHMMAQQCD--LEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRK 235 ++ +A++ +++G W H+Y + + +L ++ Sbjct: 208 IFNRDVIAAEIARRTGKTIKLGRLNWQADSYHIYGKDIAEAKARL------FDRIPRGPL 261 Query: 236 PESIFDYRFEDFE 248 + +++ E + Sbjct: 262 ADRTYEFSDEGIQ 274 >UniRef50_D2B6A6 Putative uncharacterized protein n=1 Tax=Streptosporangium roseum DSM 43021 RepID=D2B6A6_STRRD Length = 238 Score = 70.3 bits (171), Expect = 6e-11, Method: Composition-based stats. Identities = 27/136 (19%), Positives = 44/136 (32%), Gaps = 8/136 (5%) Query: 90 LGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAF 149 YG + R +DQ+ V + L+ P ++ +S GE PC Sbjct: 80 FKYSYGGRLRRL-----LGVDQLHWVADVLRAKPYTKSGWISLTVPGESPDA--VPCLTS 132 Query: 150 FQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLY 209 F + DG+L RS +VF + ++ +A + G H+Y Sbjct: 133 LAFRLRDGRLVMTAAFRSQNVFTSYLNYVPLRSIQNE-VAGDLGVGCGSMRVFVDVPHIY 191 Query: 210 SNHMDQTHLQLSREPR 225 L R Sbjct: 192 VADAAAVGEILRLSER 207 >UniRef50_A9A0S4 Thymidylate synthase-like protein n=2 Tax=Desulfobacteraceae RepID=A9A0S4_DESOH Length = 263 Score = 68.4 bits (166), Expect = 3e-10, Method: Composition-based stats. Identities = 35/141 (24%), Positives = 56/141 (39%), Gaps = 4/141 (2%) Query: 79 IWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKN-DPDSRRIIVSAWNVGE 137 W E A E D GK + +I+QI V++ K + ++++ + Sbjct: 121 WWHENASEIVDRREPDGKI--VFEEDGRLYINQIEWVIDTYKRFGARNNQMVLQVAEPSD 178 Query: 138 LDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVG 197 L + PC + D +L +Y RS D++ GLP N+A L MA + + G Sbjct: 179 LALL-DPPCLRSIDTRIQDDQLIFFVYFRSWDLWGGLPANLAGIQNLKEYMAGEIGVADG 237 Query: 198 DFVWTGGDTHLYSNHMDQTHL 218 + HLY D L Sbjct: 238 PMIVESKGLHLYGYAEDLAKL 258 >UniRef50_Q5D6W4 Thymidylate synthase-like protein n=3 Tax=Enterobacteriaceae RepID=Q5D6W4_ECOLX Length = 105 Score = 67.6 bits (164), Expect = 4e-10, Method: Composition-based stats. Identities = 24/56 (42%), Positives = 37/56 (66%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSII 56 M Y +L+++V+ GT DRTG GT+SI+G ++FNLQ+GFP T K ++ + Sbjct: 1 MDNYKDLLREVIITGTDSVDRTGVGTVSIWGAMLKFNLQEGFPATTCKGLAWKAFL 56 >UniRef50_C2KJS6 Possible thymidylate synthase n=1 Tax=Leuconostoc mesenteroides subsp. cremoris ATCC 19254 RepID=C2KJS6_LEUMC Length = 168 Score = 67.2 bits (163), Expect = 5e-10, Method: Composition-based stats. Identities = 18/85 (21%), Positives = 36/85 (42%), Gaps = 3/85 (3%) Query: 161 CQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQL 220 +Y R+ D F G+ +I S+ + MA++ +L+VG + + G H+Y L Sbjct: 1 MVVYMRANDAFRGMVSDIFSFTFIQEFMARELNLKVGKYYHSMGTMHIYEPDNQWVKHVL 60 Query: 221 SR---EPRPLPKLIIKRKPESIFDY 242 + + PK+ + + Sbjct: 61 NESNDQTFISPKMPQGNNWAMVHEL 85 >UniRef50_C0GRD7 Thymidylate synthase-like protein n=1 Tax=Desulfonatronospira thiodismutans ASO3-1 RepID=C0GRD7_9DELT Length = 224 Score = 66.1 bits (160), Expect = 1e-09, Method: Composition-based stats. Identities = 26/126 (20%), Positives = 48/126 (38%), Gaps = 2/126 (1%) Query: 102 PTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSC 161 T R Q+ + + + + I+ + + PC + DG+L Sbjct: 100 YTYGERIYQQVLYWIGKFNQTWATNQAILQVGRPED-HLLNDPPCLRHIDMRIRDGRLIF 158 Query: 162 QLYQRSCDVFLGLPFNIASYALLVHMMAQQC-DLEVGDFVWTGGDTHLYSNHMDQTHLQL 220 Y RS D++ G P N+A A+L MA + G + + H+Y + ++ Sbjct: 159 YPYFRSWDLWGGFPANLAGIAVLQKYMADSIEGVSPGPILASSKGLHIYGYAEELARIRT 218 Query: 221 SREPRP 226 R+ P Sbjct: 219 CRKDAP 224 >UniRef50_D1YXV9 Thymidylate synthase n=2 Tax=Euryarchaeota RepID=D1YXV9_METPS Length = 212 Score = 57.6 bits (138), Expect = 4e-07, Method: Composition-based stats. Identities = 29/123 (23%), Positives = 49/123 (39%), Gaps = 8/123 (6%) Query: 105 DGRHIDQITTVLNQLKNDP-DSRRIIVSAWNVGELDKMA--LAPCHAFFQ-FYVADGKLS 160 + DQ+ + QL+N +S+RI W +D M PC F + KL Sbjct: 91 NYEGFDQLKWMGEQLQNKRYESKRIQAITWMPK-IDCMKKEDQPCFQRIWVFPHKNNKLD 149 Query: 161 CQLYQRSCDVFLGLPFNIASYALLV--HMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHL 218 ++ RS D+F N+ ++ LV ++ D +G G + H+Y + Sbjct: 150 VHIHYRSWDMFKAFEANLMAFQELVKDELI-GPTDFMLGTLRCFGDNVHIYEDDFQAAEE 208 Query: 219 QLS 221 L Sbjct: 209 VLK 211 >UniRef50_B0YLJ0 Thymidylate synthase n=1 Tax=Glossina pallidipes salivary gland hypertrophy virus RepID=B0YLJ0_9VIRU Length = 115 Score = 55.3 bits (132), Expect = 2e-06, Method: Composition-based stats. Identities = 20/75 (26%), Positives = 40/75 (53%), Gaps = 6/75 (8%) Query: 2 KQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQ-DGFPLVTTKRCHLRSIIHELL 60 +Y L+ +++ G + +S+FG Q+ ++L+ FPL +KR +I ELL Sbjct: 21 NKYPTLVNNIIEHGISTEKK-----ISVFGAQLEYDLRNKKFPLFISKRYDWAYVIEELL 75 Query: 61 WFLQGDTNIAYLHEN 75 W ++G+T+ ++ Sbjct: 76 WCIRGETDRKNINSR 90 >UniRef50_B5UXF2 Putative uncharacterized protein n=1 Tax=Bacillus cereus AH1134 RepID=B5UXF2_BACCE Length = 260 Score = 54.5 bits (130), Expect = 4e-06, Method: Composition-based stats. Identities = 15/115 (13%), Positives = 38/115 (33%), Gaps = 6/115 (5%) Query: 92 PVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRII-----VSAWNVGELDKMAL-AP 145 Y + W G +Q+ + +L + ++ R I +S ++ + P Sbjct: 103 GTYFGRLVEWNYGRGETFNQLDHTILKLAREKNNGRGIRVMYEMSIYDPNLDHNNQMGFP 162 Query: 146 CHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFV 200 C +F + + R+ N L+ ++++ ++G Sbjct: 163 CMSFISLKIRKDFIDLTAIYRNQYFVQKAYGNYLGLGRLLEFISKESGYKMGKLT 217 >UniRef50_B0YLI9 Thymidylate synthase-like protein n=1 Tax=Glossina pallidipes salivary gland hypertrophy virus RepID=B0YLI9_9VIRU Length = 87 Score = 53.7 bits (128), Expect = 7e-06, Method: Composition-based stats. Identities = 19/79 (24%), Positives = 37/79 (46%) Query: 175 PFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKR 234 P IA Y+LL +M+A C+L +T G +++ +D + P+LI++ Sbjct: 6 PLTIAKYSLLTYMIAYVCNLMPYSITYTMGVSYINKYELDILQSYTKMKQYKFPRLIVEH 65 Query: 235 KPESIFDYRFEDFEIEGYD 253 + I+ + +F + Y Sbjct: 66 YVKDIYSFNLGNFLLYDYQ 84 >UniRef50_Q82RC3 Putative uncharacterized protein n=2 Tax=Streptomyces RepID=Q82RC3_STRAW Length = 267 Score = 53.7 bits (128), Expect = 7e-06, Method: Composition-based stats. Identities = 44/224 (19%), Positives = 70/224 (31%), Gaps = 42/224 (18%) Query: 19 NDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFL-------------QG 65 DRTG T+ + P+ + LR+ LW L Sbjct: 33 PDRTGLHTVVRIA-----DPTSDDPVFRAELDRLRTARG--LWPLETVASTLFPAALAAR 85 Query: 66 DTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDS 125 + L E ++ G+ Y + +P IDQ++TV+++L+ Sbjct: 86 SADPDDLAERYRRMYPVIKRYPGNHRGTYFGRLVFYPAASKTGIDQLSTVISRLRTQAAG 145 Query: 126 RRI-------IVSAWNVGELDKMALA------------PC--HAFFQFYVADGKLSCQLY 164 +I I +A + E L PC H Q D ++ Sbjct: 146 TKIAAAYEIDIAAATDQEEAGADLLVHTAGKDNSYIGFPCLSHISLQLD-RDRRVHAAAL 204 Query: 165 QRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHL 208 RS +F N L+ +AQQ +L G G L Sbjct: 205 YRSHFMFERAYGNYLGLGRLLAYIAQQAELACGTLTVMAGHARL 248 >UniRef50_A5VDP1 Putative uncharacterized protein n=2 Tax=Alphaproteobacteria RepID=A5VDP1_SPHWW Length = 260 Score = 44.1 bits (103), Expect = 0.004, Method: Composition-based stats. Identities = 24/160 (15%), Positives = 59/160 (36%), Gaps = 16/160 (10%) Query: 71 YLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRII- 129 + + + ++ Y ++ P G I+Q+T ++ +LK+ S + Sbjct: 87 FFDRFRDNVLPKVRNKGDRWSGYYFERMMQLPQLKGEPINQLTDIIRRLKDSSIS--ALN 144 Query: 130 ---VSAWNVGELDKMALAP----CHAFFQFY-VADG---KLSCQLYQRSCDVFLGLPFNI 178 +S ++ + +P C +F F + DG +L+ R+ L N+ Sbjct: 145 KFELSVFDPA--RDVDDSPYGGQCLSFASFKPIGDGSNRRLALTAMYRNHYYIEKLLGNL 202 Query: 179 ASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHL 218 L+ +A + + G + ++ ++T + Sbjct: 203 IGLGRLMAFVAAEAGIAPGPLTILSTHATIDTDKWNRTDI 242 >UniRef50_C8SR56 Putative uncharacterized protein n=1 Tax=Mesorhizobium opportunistum WSM2075 RepID=C8SR56_9RHIZ Length = 258 Score = 43.3 bits (101), Expect = 0.008, Method: Composition-based stats. Identities = 27/153 (17%), Positives = 55/153 (35%), Gaps = 17/153 (11%) Query: 69 IAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRH---IDQITTVLNQLKNDPDS 125 I L + + +++ G+ G Y ++ AWP GR ++Q++ + L+ Sbjct: 82 IDALTKRYMQVYERRMHRQGEWGR-YFQRMVAWPNGGGRGAGTVNQLSANIETLRAMRSG 140 Query: 126 RRII------VSAWNVG-ELDKMALAPCHAFFQFY-VADG---KLSCQLYQRSCDVFLGL 174 ++ ++ +L K C +F + G +LS R+ Sbjct: 141 EAKFFGNVTEIALFDPARDLRKKMNRQCLSFIELKPERQGNIWRLSMMAVYRNHYYVQRT 200 Query: 175 PFNIASYALLVHMMAQQCDLEVGDFVWTGGDTH 207 N+ L+ +A + E+G TH Sbjct: 201 LGNLIGLGRLLQFIANETGFEIGTLT--IQSTH 231 >UniRef50_A8P7A1 Putative uncharacterized protein n=1 Tax=Brugia malayi RepID=A8P7A1_BRUMA Length = 83 Score = 40.3 bits (93), Expect = 0.061, Method: Composition-based stats. Identities = 25/78 (32%), Positives = 41/78 (52%), Gaps = 16/78 (20%) Query: 73 HENNVTIWDEWADE-------NGDLGPVYGKQ-------WRAWPT-PDGRHIDQITTVLN 117 +E+ D++ DE GDL PVYG Q +R + IDQ++ +++ Sbjct: 6 NEDENKYLDQFLDECDFSDRSEGDLRPVYGFQGNTVLAEYRGMDADYINQGIDQLSEIID 65 Query: 118 QLKNDPDSRRIIVSAWNV 135 +KN+P +R I++AWNV Sbjct: 66 LMKNEPHNR-CILNAWNV 82 >UniRef50_C0LGV1 LRR receptor-like serine/threonine-protein kinase RCH1 n=1 Tax=Arabidopsis thaliana RepID=RCH1_ARATH Length = 1135 Score = 39.9 bits (92), Expect = 0.092, Method: Composition-based stats. Identities = 20/79 (25%), Positives = 32/79 (40%), Gaps = 7/79 (8%) Query: 129 IVSAWNVGELDKMALAPCHA-FFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHM 187 + S WN + D PC + +D KL ++ S + L P NI+S+ L + Sbjct: 57 VFSGWNPSDSD-----PCQWPYITCSSSDNKLVTEINVVSVQLALPFPPNISSFTSLQKL 111 Query: 188 MAQQCDLEVGDFVWTGGDT 206 + +L G GD Sbjct: 112 VISNTNLT-GAISSEIGDC 129 Searching..................................................done Results from round 3 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_C0ZI91 Thymidylate synthase n=24 Tax=cellular organisms... 396 e-109 UniRef50_P04818 Thymidylate synthase n=326 Tax=root RepID=TYSY_H... 367 e-100 UniRef50_C5BMA3 Thymidylate synthase n=8 Tax=cellular organisms ... 363 4e-99 UniRef50_Q07422 Thymidylate synthase n=6 Tax=cellular organisms ... 354 2e-96 UniRef50_Q4U9G5 Bifunctional dihydrofolate reductase/thymidilate... 353 4e-96 UniRef50_Q4A320 Bifunctional dihydrofolate reductase-thymidylate... 352 7e-96 UniRef50_Q2TA32 Thymidylate synthase n=5 Tax=cellular organisms ... 351 2e-95 UniRef50_Q1Q8B2 Thymidylate synthase n=702 Tax=root RepID=TYSY_P... 347 2e-94 UniRef50_C3RUB2 Dihydrofolate reductase-thymidylate synthase n=1... 345 1e-93 UniRef50_O02604 Thymidylate synthase n=87 Tax=Plasmodium RepID=D... 344 1e-93 UniRef50_C4Q3X9 Thymidylate synthase n=3 Tax=root RepID=C4Q3X9_S... 340 3e-92 UniRef50_Q27828 Thymidylate synthase n=1 Tax=Paramecium tetraure... 339 4e-92 UniRef50_A9NG27 Thymidylate synthase n=12 Tax=cellular organisms... 338 1e-91 UniRef50_Q4A611 Thymidylate synthase n=15 Tax=Mollicutes RepID=T... 338 1e-91 UniRef50_Q27783 Thymidylate synthase n=25 Tax=Trypanosomatidae R... 338 2e-91 UniRef50_D2CLW7 Dihydrofolate reductase-thymidylate synthase n=7... 337 2e-91 UniRef50_O96650 Thymidylate synthase n=17 Tax=root RepID=TYSY_ASCSU 332 7e-90 UniRef50_D2W4C0 Predicted protein n=1 Tax=Naegleria gruberi RepI... 331 1e-89 UniRef50_Q67JQ1 Thymidylate synthase n=1 Tax=Symbiobacterium the... 331 2e-89 UniRef50_B6AE97 Thymidylate synthase family protein n=4 Tax=cell... 328 1e-88 UniRef50_Q27713 Thymidylate synthase n=5 Tax=Plasmodium RepID=DR... 328 1e-88 UniRef50_Q98Q31 Thymidylate synthase n=2 Tax=root RepID=TYSY_MYCPU 327 3e-88 UniRef50_Q9UTI7 Probable thymidylate synthase n=17 Tax=cellular ... 326 3e-88 UniRef50_B1C3H3 Thymidylate synthase n=6 Tax=Bacteria RepID=B1C3... 324 1e-87 UniRef50_Q0FG99 Thymidylate synthase n=4 Tax=root RepID=Q0FG99_9... 321 2e-86 UniRef50_Q76YC2 DTMP synthase n=1 Tax=Aeromonas phage Aeh1 RepID... 315 7e-85 UniRef50_P00471 Thymidylate synthase n=17 Tax=T4-like viruses Re... 311 2e-83 UniRef50_Q8WYK3 Thymidylate synthase n=4 Tax=Eutheria RepID=Q8WY... 309 5e-83 UniRef50_Q3J0W9 Thymidylate synthase n=12 Tax=Bacteria RepID=TYS... 309 6e-83 UniRef50_Q4PBV6 Thymidylate synthase n=3 Tax=Dikarya RepID=Q4PBV... 309 7e-83 UniRef50_A2R2F6 Thymidylate synthase n=20 Tax=Leotiomyceta RepID... 308 1e-82 UniRef50_Q04FR4 Thymidylate synthase n=279 Tax=cellular organism... 306 6e-82 UniRef50_A5KSZ1 Thymidylate synthase n=1 Tax=candidate division ... 305 1e-81 UniRef50_Q2G6V6 Thymidylate synthase n=14 Tax=Bacteria RepID=TYS... 303 4e-81 UniRef50_Q6QGJ5 Putative thymidylate synthase n=1 Tax=Enterobact... 299 5e-80 UniRef50_D2XB64 Bifunctional dihydrofolate reductase-thymidylate... 299 8e-80 UniRef50_D1BNV6 Thymidylate synthase n=4 Tax=Veillonellaceae Rep... 298 1e-79 UniRef50_Q65J44 Thymidylate synthase n=9 Tax=root RepID=TYSY_BACLD 292 9e-78 UniRef50_A3QU09 Thymidylate synthase n=1 Tax=Oryctes rhinoceros ... 291 1e-77 UniRef50_A6M378 Thymidylate synthase n=8 Tax=Clostridium RepID=T... 283 5e-75 UniRef50_B2YFY9 Thymidylate synthase n=1 Tax=Musca domestica sal... 282 7e-75 UniRef50_Q88CN9 Thymidylate synthase n=74 Tax=Proteobacteria Rep... 275 8e-73 UniRef50_A9UZA9 Thymidylate synthase n=1 Tax=Monosiga brevicolli... 271 2e-71 UniRef50_Q5UQG3 Thymidylate synthase n=1 Tax=Acanthamoeba polyph... 271 2e-71 UniRef50_A8RRN6 Thymidylate synthase n=16 Tax=Bacteria RepID=A8R... 270 3e-71 UniRef50_Q6WIC0 DTMP (Thymidylate) synthase n=1 Tax=Vibrio phage... 268 1e-70 UniRef50_B6FSV1 Putative uncharacterized protein n=1 Tax=Clostri... 268 2e-70 UniRef50_C4Z7Z1 Thymidylate synthase n=19 Tax=Bacteria RepID=C4Z... 265 1e-69 UniRef50_A8H1B4 Thymidylate synthase n=132 Tax=root RepID=TYSY_S... 261 2e-68 UniRef50_Q8RGP6 Thymidylate synthase n=10 Tax=Fusobacterium RepI... 257 2e-67 UniRef50_UPI0001925B1E PREDICTED: similar to thymidylate synthas... 255 1e-66 UniRef50_B9CJY5 Thymidylate synthase n=10 Tax=Bacteria RepID=B9C... 254 2e-66 UniRef50_B7C7C1 Putative uncharacterized protein n=1 Tax=Eubacte... 254 2e-66 UniRef50_D2RRK7 Thymidylate synthase n=9 Tax=cellular organisms ... 254 2e-66 UniRef50_Q8WYK4 Thymidylate synthase n=7 Tax=Fungi/Metazoa group... 254 3e-66 UniRef50_C6JM98 Thymidylate synthase n=6 Tax=Fusobacterium RepID... 250 3e-65 UniRef50_C3IV33 Thymidylate synthase n=2 Tax=Bacillus thuringien... 248 1e-64 UniRef50_Q934U8 Putative thymidylate synthase n=1 Tax=Salmonella... 246 7e-64 UniRef50_A8E2Q5 Putative thymidylate synthase n=1 Tax=Enterococc... 244 3e-63 UniRef50_B9LR89 Thymidylate synthase n=4 Tax=Halobacteriaceae Re... 240 2e-62 UniRef50_C5H7L6 Thymidylate synthase n=3 Tax=unclassified Myovir... 235 9e-61 UniRef50_A2SMX7 Thymidylate synthase n=1 Tax=Methylibium petrole... 225 9e-58 UniRef50_B8QTX3 Putative thymidylate synthase n=1 Tax=Erwinia ph... 223 5e-57 UniRef50_C7HUX5 Thymidylate synthase n=2 Tax=Anaerococcus RepID=... 220 5e-56 UniRef50_Q03LN3 Thymidylate synthase n=75 Tax=Firmicutes RepID=T... 207 2e-52 UniRef50_B4Y380 MilA n=1 Tax=Streptomyces rimofaciens RepID=B4Y3... 205 1e-51 UniRef50_B4TEI9 Thymidylate synthase n=2 Tax=Enterobacteriaceae ... 203 6e-51 UniRef50_Q13T72 Thymidylate synthase n=4 Tax=Burkholderiaceae Re... 202 8e-51 UniRef50_B2IB94 Thymidylate synthase n=2 Tax=Rhizobiales RepID=B... 200 3e-50 UniRef50_B0T6R4 Thymidylate synthase n=1 Tax=Caulobacter sp. K31... 200 3e-50 UniRef50_C0ELR2 Putative uncharacterized protein n=1 Tax=Neisser... 199 1e-49 UniRef50_Q6X183 Thymidylate synthase (Fragment) n=1 Tax=Enteroba... 198 2e-49 UniRef50_B2HI72 Thymidylate synthase, ThyA_1 n=1 Tax=Mycobacteri... 198 2e-49 UniRef50_Q7Y427 dTMP (Thymidylate) synthase n=3 Tax=unclassified... 197 2e-49 UniRef50_Q03W75 Thymidylate synthase n=13 Tax=Bacteria RepID=Q03... 195 2e-48 UniRef50_A7TUR1 Putative thymidylate synthase n=3 Tax=Streptomyc... 194 2e-48 UniRef50_C8S1P3 Thymidylate synthase n=1 Tax=Rhodobacter sp. SW2... 191 2e-47 UniRef50_P31654 Deoxyuridylate hydroxymethyltransferase n=2 Tax=... 189 9e-47 UniRef50_B5S769 Putative thymidylate synthase protein n=1 Tax=Ra... 181 2e-44 UniRef50_B5UXF4 Thymidylate synthase n=1 Tax=Bacillus cereus AH1... 179 8e-44 UniRef50_C4SF99 Deoxyuridylate hydroxymethyltransferase n=1 Tax=... 175 9e-43 UniRef50_Q2T5Q0 Deoxyuridylate hydroxymethyltransferase , putati... 174 2e-42 UniRef50_UPI00016AD9CB thymidylate synthase n=1 Tax=Burkholderia... 173 4e-42 UniRef50_B2ZYD3 Deoxyuridylate hydroxymethyltransferase n=1 Tax=... 172 9e-42 UniRef50_B3FJL1 Putative uncharacterized protein n=1 Tax=Pseudom... 169 9e-41 UniRef50_Q2FCV1 Thymidylate synthase n=2 Tax=Acinetobacter bauma... 168 2e-40 UniRef50_Q5DN81 Thymidylate synthase n=3 Tax=unclassified Siphov... 167 3e-40 UniRef50_B8GIB9 Thymidylate synthase, methanogen type n=1 Tax=Me... 164 3e-39 UniRef50_O26868 Putative thymidylate synthase n=2 Tax=Methanothe... 163 4e-39 UniRef50_Q1ZMM6 Thymidylate synthase n=3 Tax=Gammaproteobacteria... 163 5e-39 UniRef50_Q46E28 Putative thymidylate synthase n=5 Tax=Methanosar... 162 9e-39 UniRef50_Q8MVZ9 Bifunctional dihydrofolate reductase-thymidylate... 162 1e-38 UniRef50_Q21ZJ9 Thymidylate synthase n=1 Tax=Rhodoferax ferrired... 160 5e-38 UniRef50_B3QQU8 Thymidylate synthase n=1 Tax=Chlorobaculum parvu... 158 2e-37 UniRef50_UPI00016AEAE5 thymidylate synthase n=1 Tax=Burkholderia... 157 4e-37 UniRef50_C5U4L9 Thymidylate synthase, methanogen type n=1 Tax=Me... 156 6e-37 UniRef50_C9DGK1 Deoxyuridylate hydroxymethyltransferase n=1 Tax=... 155 2e-36 UniRef50_B2TJD1 Thymidylate synthase n=1 Tax=Clostridium botulin... 153 4e-36 UniRef50_Q2NEY9 ThyA n=1 Tax=Methanosphaera stadtmanae DSM 3091 ... 152 1e-35 UniRef50_Q7Y590 Putative uncharacterized protein RB69ORF048c n=3... 151 2e-35 UniRef50_Q57931 Putative thymidylate synthase n=11 Tax=Methanoco... 151 2e-35 UniRef50_Q52PP0 Putative thymidylate synthase n=1 Tax=Xanthomona... 145 1e-33 UniRef50_C8XUG3 Putative thymidylate synthase n=1 Tax=Shigella p... 143 5e-33 UniRef50_A3CSY2 Thymidylate synthase n=3 Tax=Methanomicrobiales ... 143 8e-33 UniRef50_A5UP11 Predicted thymidylate synthase, ThyA n=2 Tax=Met... 141 2e-32 UniRef50_UPI0001C42129 thymidylate synthase ThyA n=1 Tax=Methano... 141 3e-32 UniRef50_P18029 Deoxycytidylate 5-hydroxymethyltransferase n=10 ... 141 3e-32 UniRef50_C9KVG6 Thymidylate synthase n=14 Tax=Bacteroidales RepI... 138 2e-31 UniRef50_UPI0001C33797 thymidylate synthase n=3 Tax=Cyanobacteri... 136 9e-31 UniRef50_B7KFY9 Thymidylate synthase n=11 Tax=Cyanobacteria RepI... 134 2e-30 UniRef50_A2E1C8 Putative uncharacterized protein n=1 Tax=Trichom... 131 2e-29 UniRef50_B1ZRC5 Thymidylate synthase-like protein n=1 Tax=Opitut... 127 5e-28 UniRef50_Q8MVZ8 Bifunctional dihydrofolate reductase-thymidylate... 125 2e-27 UniRef50_O28232 Thymidylate synthase, putative n=2 Tax=Archaeogl... 124 3e-27 UniRef50_Q8MW00 Bifunctional dihydrofolate reductase-thymidylate... 123 6e-27 UniRef50_Q8MVZ6 Bifunctional dihydrofolate reductase-thymidylate... 123 6e-27 UniRef50_A1RYR8 Thymidylate synthase-like protein n=1 Tax=Thermo... 123 7e-27 UniRef50_Q8TVL9 Putative thymidylate synthase n=1 Tax=Methanopyr... 123 9e-27 UniRef50_Q8MVZ5 Bifunctional dihydrofolate reductase-thymidylate... 116 8e-25 UniRef50_Q2FKU7 Thymidylate synthase-like n=1 Tax=Methanospirill... 114 3e-24 UniRef50_D2BHQ5 Thymidylate synthase n=5 Tax=Dehalococcoides Rep... 111 2e-23 UniRef50_A9A0S4 Thymidylate synthase-like protein n=2 Tax=Desulf... 108 2e-22 UniRef50_B8KML0 Putative thymidylate synthase n=1 Tax=gamma prot... 108 2e-22 UniRef50_C0GRD7 Thymidylate synthase-like protein n=1 Tax=Desulf... 105 2e-21 UniRef50_D2B6A6 Putative uncharacterized protein n=1 Tax=Strepto... 102 1e-20 UniRef50_A5KRW4 Thymidylate synthase-like protein n=1 Tax=candid... 100 4e-20 UniRef50_D1YXV9 Thymidylate synthase n=2 Tax=Euryarchaeota RepID... 100 6e-20 UniRef50_Q82RC3 Putative uncharacterized protein n=2 Tax=Strepto... 95 2e-18 UniRef50_B5UXF2 Putative uncharacterized protein n=1 Tax=Bacillu... 85 2e-15 UniRef50_C2KJS6 Possible thymidylate synthase n=1 Tax=Leuconosto... 84 4e-15 UniRef50_B9PCT2 Predicted protein (Fragment) n=2 Tax=root RepID=... 80 7e-14 UniRef50_B0YLI9 Thymidylate synthase-like protein n=1 Tax=Glossi... 76 1e-12 UniRef50_UPI0001742C7A thymidylate synthase n=1 Tax=candidate di... 73 7e-12 UniRef50_C7JA78 Os12g0446900 protein (Fragment) n=1 Tax=Oryza sa... 72 2e-11 UniRef50_Q5D6W4 Thymidylate synthase-like protein n=3 Tax=Entero... 65 3e-09 UniRef50_B0YLJ0 Thymidylate synthase n=1 Tax=Glossina pallidipes... 61 5e-08 Sequences not found previously or not previously below threshold: UniRef50_A5VDP1 Putative uncharacterized protein n=2 Tax=Alphapr... 63 1e-08 UniRef50_C8SR56 Putative uncharacterized protein n=1 Tax=Mesorhi... 57 6e-07 UniRef50_A5ETP5 Putative uncharacterized protein n=1 Tax=Bradyrh... 56 2e-06 UniRef50_A1KLI7 Putative uncharacterized protein BCG_2512 n=13 T... 55 3e-06 UniRef50_A8P7A1 Putative uncharacterized protein n=1 Tax=Brugia ... 43 0.011 >UniRef50_C0ZI91 Thymidylate synthase n=24 Tax=cellular organisms RepID=TYSY_BREBN Length = 264 Score = 396 bits (1019), Expect = e-109, Method: Composition-based stats. Identities = 179/264 (67%), Positives = 215/264 (81%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL 60 MKQYL+L Q++LDEG K DRTGTGT S+FGHQMRF+L +GFP+VTTK+ H++SIIHELL Sbjct: 1 MKQYLDLCQRILDEGVIKEDRTGTGTTSVFGHQMRFDLSEGFPMVTTKKLHMKSIIHELL 60 Query: 61 WFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLK 120 WFL GDTN+ YL EN V IW+EWADENGDLGPVYG QWR++ DG+ +DQI V++++K Sbjct: 61 WFLSGDTNVRYLQENGVRIWNEWADENGDLGPVYGSQWRSFTGRDGKTVDQIQWVIDEIK 120 Query: 121 NDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIAS 180 +PDSRR+IVSAWN ELDKMAL PCH FQFYVA+GKLSCQLYQRS D FLG+PFNIAS Sbjct: 121 RNPDSRRLIVSAWNPAELDKMALPPCHLLFQFYVANGKLSCQLYQRSGDTFLGVPFNIAS 180 Query: 181 YALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIF 240 YALL HM+A LEVGDFV T GD HLY NH++Q LQL+REP+PLPKL++ SIF Sbjct: 181 YALLTHMVAHVTGLEVGDFVHTIGDAHLYLNHIEQVKLQLTREPKPLPKLVLNPDVTSIF 240 Query: 241 DYRFEDFEIEGYDPHPGIKAPVAI 264 D+++ED EI GY+ HP IK VA+ Sbjct: 241 DFKYEDIEIVGYESHPHIKGEVAV 264 >UniRef50_P04818 Thymidylate synthase n=326 Tax=root RepID=TYSY_HUMAN Length = 313 Score = 367 bits (943), Expect = e-100, Method: Composition-based stats. Identities = 143/282 (50%), Positives = 186/282 (65%), Gaps = 20/282 (7%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62 QYL +Q +L G +K+DRTGTGTLS+FG Q R++L+D FPL+TTKR + ++ ELLWF Sbjct: 32 QYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWF 91 Query: 63 LQGDTNIAYLHENNVTIWDEWADEN------------GDLGPVYGKQWRAW--------P 102 ++G TN L V IWD + GDLGPVYG QWR + Sbjct: 92 IKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEGDLGPVYGFQWRHFGAEYRDMES 151 Query: 103 TPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQ 162 G+ +DQ+ V++ +K +PD RRII+ AWN +L MAL PCHA QFYV + +LSCQ Sbjct: 152 DYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSCQ 211 Query: 163 LYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSR 222 LYQRS D+ LG+PFNIASYALL +M+A L+ GDF+ T GD H+Y NH++ +QL R Sbjct: 212 LYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQR 271 Query: 223 EPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 EPRP PKL I RK E I D++ EDF+IEGY+PHP IK +A+ Sbjct: 272 EPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPHPTIKMEMAV 313 >UniRef50_C5BMA3 Thymidylate synthase n=8 Tax=cellular organisms RepID=TYSY_TERTT Length = 277 Score = 363 bits (932), Expect = 4e-99, Method: Composition-based stats. Identities = 164/277 (59%), Positives = 203/277 (73%), Gaps = 13/277 (4%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL 60 MKQYLELM+ V D G +K DRTGTGT+S+FG+QMRF+L GFPLVTTK+CHL+SIIHELL Sbjct: 1 MKQYLELMRHVRDNGVRKEDRTGTGTVSVFGYQMRFDLSQGFPLVTTKKCHLKSIIHELL 60 Query: 61 WFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLK 120 WFL G+TNIAYL+ N V IWD WA E+GDLGP+YG QWR+WP +G +DQI+ ++ Q+K Sbjct: 61 WFLNGETNIAYLNNNGVKIWDAWATESGDLGPIYGAQWRSWPAQNGETLDQISQLIEQIK 120 Query: 121 NDPDSRRIIVSAWNVGELDK-------------MALAPCHAFFQFYVADGKLSCQLYQRS 167 + PDSRR+I+SAWN L MAL PCH FQFYV +G+LSCQLYQRS Sbjct: 121 HKPDSRRLIISAWNPALLPDESISPQDNVRNGKMALPPCHTLFQFYVLEGRLSCQLYQRS 180 Query: 168 CDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPL 227 D+FLG+PFNIASYALL M+AQ L GDFV T GD HLY NH++Q QL R+P PL Sbjct: 181 ADIFLGVPFNIASYALLTMMIAQVTGLAPGDFVHTFGDAHLYLNHLEQVDTQLQRQPLPL 240 Query: 228 PKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 P + I + IF + F+DFE++ Y HP I AP+++ Sbjct: 241 PTMAINPAVKDIFGFCFDDFELQNYQAHPHIAAPISV 277 >UniRef50_Q07422 Thymidylate synthase n=6 Tax=cellular organisms RepID=DRTS_TOXGO Length = 610 Score = 354 bits (908), Expect = 2e-96, Method: Composition-based stats. Identities = 126/285 (44%), Positives = 176/285 (61%), Gaps = 23/285 (8%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62 QYL+L+ +++ G +DRTG G +S FG MR++L FPL+TTKR + ++ ELLWF Sbjct: 326 QYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWF 385 Query: 63 LQGDTNIAYLHENNVTIWDEWADEN------------GDLGPVYGKQWRAW--------P 102 ++GDTN +L E V IWD+ GD+GP YG QWR + Sbjct: 386 IRGDTNANHLSEKGVKIWDKNVTREFLDSRNLPHREVGDIGPGYGFQWRHFGAAYKDMHT 445 Query: 103 TPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGK-LSC 161 G+ +DQ+ V+ L+ +P RR++++AWN LD+MAL PCH QFYV D K LSC Sbjct: 446 DYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQKELSC 505 Query: 162 QLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLS 221 +YQRSCDV LG+PFNIASY+LL M+A C+L+ +F+ G+TH+Y+NH++ QL Sbjct: 506 IMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLR 565 Query: 222 REPRPLPKLIIKRK--PESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 REPRP P + I K + I D+ EDFE+ GY PH I+ +A+ Sbjct: 566 REPRPFPIVNILNKERIKEIDDFTAEDFEVVGYVPHGRIQMEMAV 610 >UniRef50_Q4U9G5 Bifunctional dihydrofolate reductase/thymidilate synthase, putative n=7 Tax=root RepID=Q4U9G5_THEAN Length = 523 Score = 353 bits (906), Expect = 4e-96, Method: Composition-based stats. Identities = 130/281 (46%), Positives = 180/281 (64%), Gaps = 20/281 (7%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62 QYLE++ +L+ G K +RTG ++ FG+QMRF+L FPL+TTK+ LR II EL+WF Sbjct: 242 QYLEILADILNNGYHKKNRTGVDCIAKFGYQMRFDLSQSFPLLTTKKVFLRGIIEELIWF 301 Query: 63 LQGDTNIAYLHENNVTIWDEWA------------DENGDLGPVYGKQWRAWP-------- 102 ++G TN L + NV IW+ E DLGPVYG QWR + Sbjct: 302 IRGSTNGNELLKKNVRIWELNGARSFLDNLGFYDREEQDLGPVYGFQWRHFGAKYIDMHA 361 Query: 103 TPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQ 162 + IDQ++ V+ ++KN+PD+RR+IV +WNV +L KMAL PCH FQF+VADG LSC Sbjct: 362 DYTDQGIDQLSLVIERIKNNPDNRRLIVCSWNVADLSKMALPPCHLLFQFFVADGTLSCM 421 Query: 163 LYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSR 222 ++QRSCD+ LG+PFNIASY+LL +M+A C L+ G+FV GD H+Y+NH+D Q+SR Sbjct: 422 MHQRSCDMGLGVPFNIASYSLLTYMIAHICGLKPGEFVHNLGDAHIYNNHIDAIKEQISR 481 Query: 223 EPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263 P P P L + ++ I D+ +D ++E Y HP IK +A Sbjct: 482 VPYPFPTLKLNKEITRIEDFTIDDIKVENYRCHPLIKMEMA 522 >UniRef50_Q4A320 Bifunctional dihydrofolate reductase-thymidylate synthase n=2 Tax=dsDNA viruses, no RNA stage RepID=Q4A320_EHV86 Length = 480 Score = 352 bits (903), Expect = 7e-96, Method: Composition-based stats. Identities = 135/281 (48%), Positives = 178/281 (63%), Gaps = 20/281 (7%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62 QYL+L+ KVL+ G ++DRTGTGT+S+FG MRFNL FPL+TTKR + + I+ ELLWF Sbjct: 199 QYLQLISKVLEHGEYRSDRTGTGTVSLFGETMRFNLSTHFPLLTTKRTYWKGIVEELLWF 258 Query: 63 LQGDTNIAYLHENNVTIWDEWA------------DENGDLGPVYGKQWRAWPT------- 103 ++G TN L NV IWD +E GDLGPVYG QWR + Sbjct: 259 IRGSTNANELAAKNVKIWDGNGSRDFLDSVGLVDNEEGDLGPVYGFQWRHFGADYKTMHD 318 Query: 104 -PDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQ 162 D + DQ+ V++Q+KN+P SRRII+SAWN L+KMAL PCH QFYV DG LSCQ Sbjct: 319 SYDSQGTDQLQNVIDQIKNNPTSRRIIMSAWNPNALEKMALPPCHLMCQFYVHDGMLSCQ 378 Query: 163 LYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSR 222 +YQRS D+ LG+PFNIASYALL ++A +L+ G+F+ GD H+Y+NH+D QL R Sbjct: 379 MYQRSADIGLGVPFNIASYALLTCLIAHFTNLKPGEFIHVIGDAHVYTNHIDALKTQLKR 438 Query: 223 EPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263 +P P + I P++IFD +D + Y HP I ++ Sbjct: 439 KPYDFPTIHINNMPKTIFDVTSDDIILNDYKCHPKIHMDMS 479 >UniRef50_Q2TA32 Thymidylate synthase n=5 Tax=cellular organisms RepID=TYSY_BOVIN Length = 354 Score = 351 bits (900), Expect = 2e-95, Method: Composition-based stats. Identities = 143/320 (44%), Positives = 188/320 (58%), Gaps = 58/320 (18%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62 QYL ++ +L G +++DRTGTGTLS+FG Q R+NL+D FPL+TTKR + ++ ELLWF Sbjct: 35 QYLGQIEHILRCGFRRDDRTGTGTLSVFGMQARYNLRDEFPLLTTKRVFWKGVLEELLWF 94 Query: 63 LQGDTNIAYLHENNVTIWDEWADEN------------GDLGPVYGKQWRAW--------P 102 ++G TN L V IWD + GDLGPVYG QWR + Sbjct: 95 IKGSTNAKELSSKGVKIWDANGSRDFLDGLGFSDRAEGDLGPVYGFQWRHFGAEYKDMDS 154 Query: 103 TPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQ 162 G+ +DQ+ V++ +K +P+ RRII+ AWN +L MAL PCHA QFYV +G+LSCQ Sbjct: 155 EYSGQGVDQLQKVIDTIKTNPNDRRIILCAWNPKDLPLMALPPCHALCQFYVVNGELSCQ 214 Query: 163 LYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQ--- 219 LYQRS D+ LG+PFNIASYALL +M+A DL+ GDFV T GD H+Y NH++ Q Sbjct: 215 LYQRSGDMGLGVPFNIASYALLTYMIAHITDLKPGDFVHTLGDAHIYLNHIEPLKTQALM 274 Query: 220 -----------------------------------LSREPRPLPKLIIKRKPESIFDYRF 244 L REPRP PKL I RK E+I D++ Sbjct: 275 ELRGQSSRSLDGDGQAGTSRWAPVATDTERDRCCELQREPRPFPKLKILRKVETIDDFQA 334 Query: 245 EDFEIEGYDPHPGIKAPVAI 264 EDF+IEGY+P+P IK +A+ Sbjct: 335 EDFQIEGYNPNPTIKMEMAV 354 >UniRef50_Q1Q8B2 Thymidylate synthase n=702 Tax=root RepID=TYSY_PSYCK Length = 290 Score = 347 bits (891), Expect = 2e-94, Method: Composition-based stats. Identities = 156/279 (55%), Positives = 201/279 (72%), Gaps = 16/279 (5%) Query: 2 KQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLW 61 + YL+L++ VL+EGT+K DRTGTGTLS FG Q+RFNL DGFPL+TTK+ HL+SI +ELLW Sbjct: 12 QAYLDLLRLVLNEGTEKGDRTGTGTLSHFGAQLRFNLADGFPLLTTKKVHLKSITYELLW 71 Query: 62 FLQGDTNIAYLHENNVTIWDEWADEN---------GDLGPVYGKQWRAWP-------TPD 105 FL G T++ YL +N V IW+EWA GDLGP+YG QWR + + Sbjct: 72 FLNGSTHVDYLQQNGVRIWNEWATSEQTARFNRPAGDLGPIYGHQWRNYGATTTADGQYN 131 Query: 106 GRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQ 165 +DQI V+ Q+K +P+SRR+IVS WN GE D++AL PCH FQF+VAD KLSCQLYQ Sbjct: 132 SDGVDQIAQVVEQIKTNPNSRRLIVSGWNPGEADQVALPPCHTLFQFFVADNKLSCQLYQ 191 Query: 166 RSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPR 225 RS D+FLG+PFNIASYA+L HM+AQ C+LEVG+F+WTGGD H+Y NH +Q LQL+R Sbjct: 192 RSADLFLGVPFNIASYAMLTHMVAQVCNLEVGEFIWTGGDCHIYQNHREQVELQLTRSLY 251 Query: 226 PLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 LP L + + IF + +ED ++GY+ HP IKA VA+ Sbjct: 252 TLPTLALNPNVKDIFAFNYEDISVDGYESHPAIKAQVAV 290 >UniRef50_C3RUB2 Dihydrofolate reductase-thymidylate synthase n=16 Tax=Plasmodium vivax RepID=C3RUB2_PLAVI Length = 630 Score = 345 bits (885), Expect = 1e-93, Method: Composition-based stats. Identities = 126/281 (44%), Positives = 176/281 (62%), Gaps = 20/281 (7%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62 QYL ++ ++ G ++ DRTG G +S FG+ M+FNL + FPL+TTK+ LR II ELLWF Sbjct: 349 QYLGIIYDIIMNGNKQGDRTGVGVMSKFGYMMKFNLSEYFPLLTTKKLFLRGIIEELLWF 408 Query: 63 LQGDTNIAYLHENNVTIWDEWADEN------------GDLGPVYGKQWRAWPT------- 103 ++G+TN L NV IW+ DLGP+YG QWR + Sbjct: 409 IRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYTNMHD 468 Query: 104 -PDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQ 162 + + +DQ+ V++ +KN+P SRRII+ AWNV +LD+MAL PCH QFYV DGKLSC Sbjct: 469 NYEDKGVDQLKNVIHLIKNEPTSRRIILCAWNVKDLDQMALPPCHILCQFYVFDGKLSCI 528 Query: 163 LYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSR 222 +YQRSCD+ LG+PFNIASY++ HM+AQ C+L+ F+ G+ H+Y+NH+D +QL+R Sbjct: 529 MYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQPAQFIHILGNAHVYNNHVDSLKVQLNR 588 Query: 223 EPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263 P P P L + + ++I D+ DF IE Y H I +A Sbjct: 589 IPYPFPTLKLNPEVKNIEDFTISDFTIENYVHHDKITMEMA 629 >UniRef50_O02604 Thymidylate synthase n=87 Tax=Plasmodium RepID=DRTS_PLAVI Length = 623 Score = 344 bits (884), Expect = 1e-93, Method: Composition-based stats. Identities = 126/281 (44%), Positives = 176/281 (62%), Gaps = 20/281 (7%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62 QYL ++ ++ G ++ DRTG G +S FG+ M+FNL + FPL+TTK+ LR II ELLWF Sbjct: 342 QYLGIIYDIIMNGNKQGDRTGVGVMSNFGYMMKFNLSEYFPLLTTKKLFLRGIIEELLWF 401 Query: 63 LQGDTNIAYLHENNVTIWDEWADEN------------GDLGPVYGKQWRAWPT------- 103 ++G+TN L NV IW+ DLGP+YG QWR + Sbjct: 402 IRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYTNMHD 461 Query: 104 -PDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQ 162 + + +DQ+ V++ +KN+P SRRII+ AWNV +LD+MAL PCH QFYV DGKLSC Sbjct: 462 NYEDKGVDQLKNVIHLIKNEPTSRRIILCAWNVKDLDQMALPPCHILCQFYVFDGKLSCI 521 Query: 163 LYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSR 222 +YQRSCD+ LG+PFNIASY++ HM+AQ C+L+ F+ G+ H+Y+NH+D +QL+R Sbjct: 522 MYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQPAQFIHILGNAHVYNNHVDSLKVQLNR 581 Query: 223 EPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263 P P P L + + ++I D+ DF IE Y H I +A Sbjct: 582 IPYPFPTLKLNPEVKNIEDFTISDFTIENYVHHDKITMEMA 622 >UniRef50_C4Q3X9 Thymidylate synthase n=3 Tax=root RepID=C4Q3X9_SCHMA Length = 577 Score = 340 bits (873), Expect = 3e-92, Method: Composition-based stats. Identities = 132/281 (46%), Positives = 175/281 (62%), Gaps = 21/281 (7%) Query: 4 YLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQD-GFPLVTTKRCHLRSIIHELLWF 62 YL L++ +L G ++ DRT TGT +FG Q+RF+L++ +PL+TTK R I+ ELLWF Sbjct: 296 YLNLLRYILANGVERRDRTDTGTFGVFGPQLRFSLRNHEYPLLTTKTVFFRGIVEELLWF 355 Query: 63 LQGDTNIAYLHENNVTIWDEWAD------------ENGDLGPVYGKQWRA--------WP 102 ++G TN L E NV WD E GDLGPVYG QWR Sbjct: 356 IRGSTNSRELAEKNVHFWDANGSREFLDGLGFTEREEGDLGPVYGFQWRHSGAEYVDCQT 415 Query: 103 TPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQ 162 G+ +DQ+ V+ ++ P RRI++ AWNV +L KMAL PCH QFYVA+ +LSCQ Sbjct: 416 DYTGQGVDQLADVIKLIRERPWDRRIMIVAWNVKDLRKMALPPCHCLVQFYVANDELSCQ 475 Query: 163 LYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSR 222 LYQRS D+ LG+PFNIASYALL M+A L+ G+FV T GD H+YSNH + Q+ R Sbjct: 476 LYQRSGDMGLGVPFNIASYALLTCMIAHVTGLKPGEFVHTIGDAHIYSNHREALLEQVKR 535 Query: 223 EPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263 PRP PKL I R+ ++I D++FEDF++ Y P+P I +A Sbjct: 536 VPRPFPKLEIIREVKNIDDFKFEDFKLIDYKPYPKIPMKMA 576 >UniRef50_Q27828 Thymidylate synthase n=1 Tax=Paramecium tetraurelia RepID=DRTS_PARTE Length = 462 Score = 339 bits (871), Expect = 4e-92, Method: Composition-based stats. Identities = 138/283 (48%), Positives = 186/283 (65%), Gaps = 21/283 (7%) Query: 2 KQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLW 61 QYL+++ K++ EG K+DRTG GT+SIFG MRFNL FPL+TTK+ R ++ ELLW Sbjct: 181 NQYLDMITKIMKEGVSKDDRTGVGTMSIFGQTMRFNLAQSFPLLTTKKVFFRGVVEELLW 240 Query: 62 FLQGDTNIAYLHENNVTIWDEWADEN------------GDLGPVYGKQWRAW-------- 101 FL+G+TN L + V IW+ DLGPVYG QWR + Sbjct: 241 FLRGNTNGKLLLDKGVKIWEGNGTREYLDTIGLQHRQEHDLGPVYGFQWRHFGAKYKDCQ 300 Query: 102 PTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSC 161 + +DQ+ ++ LKN+PDSRRII+SAWN +L +MAL PCH QF+VA+GKLSC Sbjct: 301 TDYSNQGVDQVKEIIQLLKNNPDSRRIILSAWNPIDLKQMALPPCHVMSQFFVANGKLSC 360 Query: 162 QLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLS 221 +YQRSCD LG+PFNIASYALL +M+A++C+L +G+FV GDTH+YSNH++ Q+ Sbjct: 361 MMYQRSCDFGLGIPFNIASYALLTYMLAKECNLNLGEFVHVLGDTHIYSNHVEALKKQIE 420 Query: 222 REPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 R P P P L IK +S+FDY +EDFE+ GY+ H I+ +A+ Sbjct: 421 RVPYPFPLLKIKGN-KSLFDYTYEDFELVGYNAHDKIEMKMAV 462 >UniRef50_A9NG27 Thymidylate synthase n=12 Tax=cellular organisms RepID=TYSY_ACHLI Length = 288 Score = 338 bits (867), Expect = 1e-91, Method: Composition-based stats. Identities = 155/293 (52%), Positives = 199/293 (67%), Gaps = 34/293 (11%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL 60 MKQYL+L + +++ GT K+DRTGTGT SIFG+QM F+L+DGFPL+TTK+ L+ IIHELL Sbjct: 1 MKQYLDLARHIMENGTLKSDRTGTGTKSIFGYQMFFDLKDGFPLLTTKKTFLKGIIHELL 60 Query: 61 WFLQGDTNIAYLHENNVTIW-----------------------------DEWADENGDLG 91 WF++GDTNI YL +NNV IW DE+A + GDLG Sbjct: 61 WFIKGDTNIKYLVDNNVGIWTDWPYKNYMNSSEYQGESIKEFSDKIRQSDEFAKKWGDLG 120 Query: 92 PVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQ 151 PVYG QWR + +DQI ++N LK +PDSRR+++SAWN E+ +M L PCH Q Sbjct: 121 PVYGSQWRNFN-----GVDQIEYIINTLKTNPDSRRMVLSAWNPAEIGQMMLPPCHTLIQ 175 Query: 152 FYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSN 211 FYV D KLS QLYQRS DVFLG+PFNIASYA+ + M+AQ E+G FV T GD H+Y+N Sbjct: 176 FYVVDNKLSLQLYQRSGDVFLGIPFNIASYAVFLMMVAQVTGFELGSFVHTIGDAHIYTN 235 Query: 212 HMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 H DQ +LQL+R PR LP L I + + D+++EDFE+ GYDP+P IK VA+ Sbjct: 236 HFDQINLQLTRTPRRLPILKINKSITRLEDFKYEDFELVGYDPYPPIKGVVAV 288 >UniRef50_Q4A611 Thymidylate synthase n=15 Tax=Mollicutes RepID=TYSY_MYCS5 Length = 289 Score = 338 bits (866), Expect = 1e-91, Method: Composition-based stats. Identities = 157/294 (53%), Positives = 203/294 (69%), Gaps = 35/294 (11%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL 60 MKQYL L++ + GT K DRT GT+S+FG Q R+NL++GFPL+TTK+ ++I HELL Sbjct: 1 MKQYLHLLEHIKTSGTFKKDRTNIGTISLFGLQARYNLKEGFPLLTTKKMAWKAICHELL 60 Query: 61 WFLQGDTNIAYLHENNVTIWDEW-----------------------------ADENGDLG 91 WFL+GDTNI YL +NNV IW+EW A + G+LG Sbjct: 61 WFLKGDTNIKYLVDNNVNIWNEWPYEIFKKSNDYQGESLKEFSQKIKEDSSFAQKYGELG 120 Query: 92 PVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQ 151 PVYGKQWR + +DQI+ V+N +KN+P SRR+IVSAWNV ++DKMAL PCHAFFQ Sbjct: 121 PVYGKQWRDF-----FGVDQISQVINDIKNNPTSRRLIVSAWNVAQIDKMALPPCHAFFQ 175 Query: 152 FYVADG-KLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYS 210 FYV D +LS LYQRS D+FLG+PFNIASY+LL+ M+AQ +L+VG+F+ T GD H+YS Sbjct: 176 FYVNDNNELSLHLYQRSGDMFLGVPFNIASYSLLLSMVAQVTNLKVGEFIHTIGDAHIYS 235 Query: 211 NHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 NH+DQ + QL R P LPKLI+ + ++IFD+ FED E+E Y H IKA VA+ Sbjct: 236 NHIDQVNTQLERAPYKLPKLILNKNIKNIFDFTFEDIELENYISHETIKAKVAV 289 >UniRef50_Q27783 Thymidylate synthase n=25 Tax=Trypanosomatidae RepID=DRTS_TRYBB Length = 527 Score = 338 bits (866), Expect = 2e-91, Method: Composition-based stats. Identities = 129/284 (45%), Positives = 176/284 (61%), Gaps = 21/284 (7%) Query: 2 KQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGF-PLVTTKRCHLRSIIHELL 60 +QYL L+ +++DEG K DRTG GT S+FG QMRF+L++ PL+TTKR R + ELL Sbjct: 244 EQYLNLVGRIIDEGCTKCDRTGVGTRSLFGAQMRFSLRNNRLPLLTTKRVFWRGVCEELL 303 Query: 61 WFLQGDTNIAYLHENNVTIWDEWAD------------ENGDLGPVYGKQWRAWP------ 102 WFL+G+TN L + + IWD + DLGPVYG QWR + Sbjct: 304 WFLRGETNAKLLSDKGIHIWDGNGSRAFLDSRGLTDYDEMDLGPVYGFQWRHFGADYISC 363 Query: 103 --TPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLS 160 +G+ +DQI ++ L +PD RR+I +AWN L +MAL PCH QFYV++G+LS Sbjct: 364 KVDSEGKGVDQIANIVKSLIENPDDRRMICTAWNPAALPRMALPPCHMMAQFYVSNGELS 423 Query: 161 CQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQL 220 C LYQRSCD+ LG+PFNIASYALL +MA+ L G+ V T GD H+YSNH++ QL Sbjct: 424 CMLYQRSCDMGLGVPFNIASYALLTFLMAKASGLRPGELVHTLGDAHVYSNHVEPCRKQL 483 Query: 221 SREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 R PRP P ++ K+ E + D++ D E+ Y P+P I +A+ Sbjct: 484 KRVPRPFPFIVFKQDKEFLEDFQESDIEVIDYSPYPVISMEMAV 527 >UniRef50_D2CLW7 Dihydrofolate reductase-thymidylate synthase n=75 Tax=Plasmodium RepID=D2CLW7_9APIC Length = 641 Score = 337 bits (864), Expect = 2e-91, Method: Composition-based stats. Identities = 126/281 (44%), Positives = 178/281 (63%), Gaps = 20/281 (7%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62 QYL ++ V+ G +++DRTG G LS FG+ M++NL + FPL+TTK+ +R II ELLWF Sbjct: 360 QYLNIIYDVMMNGNKQDDRTGVGVLSKFGYMMKYNLAEYFPLLTTKKLFVRGIIEELLWF 419 Query: 63 LQGDTNIAYLHENNVTIWDEWADEN------------GDLGPVYGKQWRAWPT------- 103 ++G+TN L NV IW+ DLGP+YG QWR + Sbjct: 420 IRGETNGNILLNKNVRIWEANGTREFLDNRKLFDREVNDLGPIYGFQWRHFGAEYTNMYD 479 Query: 104 -PDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQ 162 + + IDQ+ ++N +KN+P SRRII+ AWNV +LDKMAL PCH QFY+ DGKLSC Sbjct: 480 NYENKGIDQLKNIINLIKNEPTSRRIILCAWNVKDLDKMALPPCHILCQFYIFDGKLSCI 539 Query: 163 LYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSR 222 +YQRSCD+ LG+PFNIASY++ +M+AQ C+L+ +F+ G+ H+Y+NH+D +QL+R Sbjct: 540 MYQRSCDLGLGVPFNIASYSIFTYMLAQVCNLQPAEFIHVLGNAHIYNNHIDSLKIQLNR 599 Query: 223 EPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263 P P P L + + ++I D+ DF IE Y H I +A Sbjct: 600 IPYPFPTLKLNPEIKNIEDFTISDFTIENYVHHDKIAMDMA 640 >UniRef50_O96650 Thymidylate synthase n=17 Tax=root RepID=TYSY_ASCSU Length = 294 Score = 332 bits (852), Expect = 7e-90, Method: Composition-based stats. Identities = 126/284 (44%), Positives = 178/284 (62%), Gaps = 21/284 (7%) Query: 2 KQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGF-PLVTTKRCHLRSIIHELL 60 ++YL ++ ++DEG + DRTG GTLS+FG ++L++G PL+TTKR + + ++ ELL Sbjct: 11 RKYLRQIKHIIDEGDKVIDRTGVGTLSLFGLHSTYSLRNGVIPLLTTKRVYWKGVVEELL 70 Query: 61 WFLQGDTNIAYLHENNVTIWDEWADEN------------GDLGPVYGKQWRAWP------ 102 WF++GDT+ L V IWD GDLGP+YG QWR + Sbjct: 71 WFIKGDTDAKRLSAKGVKIWDANGSREFLDSQGFKDRPEGDLGPIYGFQWRHFGAEYHGT 130 Query: 103 --TPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLS 160 G+ +DQ+ V+ Q+KN+P+SRRII++AWNV +L +MAL PCH QF V +G+LS Sbjct: 131 DADYKGQGVDQLADVIEQIKNNPNSRRIILNAWNVKDLHQMALPPCHTLAQFAVKNGELS 190 Query: 161 CQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQL 220 CQLYQRS D+ LG+PFN+ASY LL HM+A C L+ G GD H+Y NH+D QL Sbjct: 191 CQLYQRSGDMGLGVPFNLASYGLLTHMIAHVCALKTGFLHHVLGDAHVYLNHIDALKEQL 250 Query: 221 SREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 SR+PRP P + + + +SI D+ E + GY+P IK P+A+ Sbjct: 251 SRDPRPFPTVHFEGRIDSIDDFTAESIILNGYNPMAPIKMPMAV 294 >UniRef50_D2W4C0 Predicted protein n=1 Tax=Naegleria gruberi RepID=D2W4C0_NAEGR Length = 535 Score = 331 bits (850), Expect = 1e-89, Method: Composition-based stats. Identities = 123/286 (43%), Positives = 178/286 (62%), Gaps = 24/286 (8%) Query: 3 QYLELMQK-VLDEGTQKNDRTGTGTLSIFGHQMRFNLQDG-FPLVTTKRCHLRSIIHELL 60 QYL+++++ +L + + +RTG GT+S FG+QM+++L++ FPL+TTKR + + EL Sbjct: 250 QYLDIIKELILSDINVREERTGVGTVSKFGYQMKYSLRNNVFPLLTTKRVFWKGVAKELF 309 Query: 61 WFLQGDTNIAYLHENNVTIWDEWADENG------------DLGPVYGKQWRAW------- 101 WF+ G TN L E ++ IWD DLGPVYG QWR W Sbjct: 310 WFISGSTNAKILSEQDIHIWDGNGSREYLDSLGFENREEMDLGPVYGFQWRHWGSSYENM 369 Query: 102 -PTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVAD--GK 158 + +DQ+ + LKN+P +RRII+SAWNV +L MAL PCH QF+V + Sbjct: 370 HTDYTNKGVDQLKKCIETLKNNPTNRRIILSAWNVSDLPNMALPPCHLMCQFWVDTDTNE 429 Query: 159 LSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHL 218 LSCQ+YQRSCD+ LG+PFNIASYALL +MAQ C+L+ GDF+ T GDTH+Y NH++ Sbjct: 430 LSCQMYQRSCDMGLGVPFNIASYALLTRLMAQVCNLKPGDFIHTLGDTHVYKNHIEPLKK 489 Query: 219 QLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 Q+ R+P+ P L++ +I D++FE ++ Y+PH IK +A+ Sbjct: 490 QIERDPKHFPLLLLDPSITNIDDFKFEHLTLQNYEPHATIKMEMAV 535 >UniRef50_Q67JQ1 Thymidylate synthase n=1 Tax=Symbiobacterium thermophilum RepID=TYSY_SYMTH Length = 283 Score = 331 bits (848), Expect = 2e-89, Method: Composition-based stats. Identities = 126/277 (45%), Positives = 177/277 (63%), Gaps = 16/277 (5%) Query: 3 QYLELMQKVLDE-------GTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSI 55 QYLEL +++L E G +RTG GT+ +FG ++ + ++GFP +TTK+ S+ Sbjct: 6 QYLELCREILAENEQEIAEGRWTPNRTGMGTVGVFGRMLKHDFKEGFPALTTKKLFFNSV 65 Query: 56 IHELLWFLQGDTNIAYLHENNVTIWDEWADENG-DLGPVYGKQWRAWPTPDGRHIDQITT 114 ELLWFL G T++ +LHE IWD+ A NG LGP+YGKQWRAW DGR DQI Sbjct: 66 KAELLWFLAGRTDLEFLHERGCHIWDKDAARNGGKLGPIYGKQWRAWEGADGRTYDQIAW 125 Query: 115 VLNQLKN--------DPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQR 166 V+ Q++ P+SRR++VS WNV +L++MAL PCH FQF+V DG+L ++QR Sbjct: 126 VIQQIREIAADPERPHPNSRRLVVSPWNVADLEEMALPPCHGPFQFHVKDGRLHLAVWQR 185 Query: 167 SCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRP 226 S D+FLG+PFNIASY+LL+HM+AQ L VG + D H+Y N +DQ LQL+REP P Sbjct: 186 SADLFLGVPFNIASYSLLLHMVAQVTGLAVGTYTHYLNDVHIYRNLLDQVRLQLTREPYP 245 Query: 227 LPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263 LP+L + + I + +D ++ Y HP I+ ++ Sbjct: 246 LPRLWLNPEVREIDQFTMDDIQLVDYKHHPPIRGELS 282 >UniRef50_B6AE97 Thymidylate synthase family protein n=4 Tax=cellular organisms RepID=B6AE97_9CRYT Length = 549 Score = 328 bits (841), Expect = 1e-88, Method: Composition-based stats. Identities = 128/283 (45%), Positives = 173/283 (61%), Gaps = 21/283 (7%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62 QYL+++ VL G + +RTG T SIFG MRF+L++ FPL+TTK LR I EL+WF Sbjct: 267 QYLDMLSNVLQNGHYRENRTGINTYSIFGASMRFDLRESFPLLTTKNVALRIIFEELMWF 326 Query: 63 LQGDTNIAYLHENNVTIWDEWAD------------ENGDLGPVYGKQWRAWPT------- 103 ++GDTN +L + V IW E DLGP+YG QWR + Sbjct: 327 IKGDTNGNHLLDKKVFIWAGNGSKEYLNKVGLGYREENDLGPIYGFQWRHFNAEYKTMHD 386 Query: 104 -PDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYV-ADGKLSC 161 +G+ +DQ+ ++ LK +P RR I+SAWN + MAL PCH QFYV + +LSC Sbjct: 387 NYNGQGVDQLANLIESLKKNPYDRRHILSAWNPSAVKYMALPPCHILSQFYVDNNNRLSC 446 Query: 162 QLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLS 221 LYQRSCD+ LG PFNIASY+LL M+A C E G+F+ GD H+Y NH++Q Q+ Sbjct: 447 SLYQRSCDLGLGCPFNIASYSLLCVMIAHICGYEPGEFIHFIGDVHIYENHVEQLKQQIK 506 Query: 222 REPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 R PRP P+L +KRK + + D+ +ED EI GY PHP I+ +A+ Sbjct: 507 RLPRPFPQLRLKRKVDKVEDFIWEDIEIIGYYPHPTIRMEMAV 549 >UniRef50_Q27713 Thymidylate synthase n=5 Tax=Plasmodium RepID=DRTS_PLABA Length = 587 Score = 328 bits (841), Expect = 1e-88, Method: Composition-based stats. Identities = 123/281 (43%), Positives = 175/281 (62%), Gaps = 20/281 (7%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62 QYL ++ ++ G +++DRTG G LS FG+ M+FNL + FPL+TTK+ +R II ELLWF Sbjct: 306 QYLNIIYDIIMHGNKQDDRTGVGVLSKFGYMMKFNLNEYFPLLTTKKLFIRGIIEELLWF 365 Query: 63 LQGDTNIAYLHENNVTIWDEWADEN------------GDLGPVYGKQWRAWPT------- 103 ++G+TN L E NV IW+ DLGP+YG QWR + Sbjct: 366 IRGETNGNTLLEKNVRIWEANGTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYTDMHD 425 Query: 104 -PDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQ 162 + +DQ+ ++N +KNDP RRII+ AWNV LD+MAL PCH QFYV DGKLSC Sbjct: 426 NYKDKGVDQLKNIINLIKNDPTCRRIILCAWNVKNLDQMALPPCHILCQFYVFDGKLSCI 485 Query: 163 LYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSR 222 +YQRSCD+ LG+PFNIASY++ +M+AQ C+L+ +F+ G+ H+Y+NH++ +QL+R Sbjct: 486 MYQRSCDLGLGVPFNIASYSIFTYMIAQVCNLQAAEFIHVLGNAHVYNNHIESLKIQLNR 545 Query: 223 EPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263 P P P L + ++I D+ DF ++ Y H I +A Sbjct: 546 TPYPFPTLKLNPDIKNIEDFTISDFTVQNYVHHDKINMDMA 586 >UniRef50_Q98Q31 Thymidylate synthase n=2 Tax=root RepID=TYSY_MYCPU Length = 286 Score = 327 bits (838), Expect = 3e-88, Method: Composition-based stats. Identities = 150/293 (51%), Positives = 195/293 (66%), Gaps = 36/293 (12%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL 60 MKQYL+ ++ VL++G K +RT T+S FG+QMRF+L GFPLVTTK+ + +I HELL Sbjct: 1 MKQYLDFLKWVLEKGKHKENRTSVDTISAFGYQMRFDLSKGFPLVTTKKTNFSAIAHELL 60 Query: 61 WFLQGDTNIAYLHENNVTIWDEW-----------------------------ADENGDLG 91 WF++GDTNI YL +N V IW++W A ++G+LG Sbjct: 61 WFIKGDTNIKYLVDNKVNIWNQWPYESYKKSQDFQSESLKEFIQKIKDDNEFAQKHGNLG 120 Query: 92 PVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQ 151 PVYGKQWR + IDQ+ V+ Q+KN+P+SRR+IVS+WN E+D M L PCH FQ Sbjct: 121 PVYGKQWRDF-----LGIDQLKKVIEQIKNNPNSRRLIVSSWNPSEIDTMLLPPCHTLFQ 175 Query: 152 FYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSN 211 FYV D KLSC LYQRS D FLG+PFNIASYALL ++AQ+ +LEVGDFV + GD H+Y N Sbjct: 176 FYVNDNKLSCHLYQRSADAFLGIPFNIASYALLTFLLAQETNLEVGDFVHSIGDAHIYVN 235 Query: 212 HMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 H++Q QL R P+ LPKLIIK ++IF+ FED E+ Y+ P IK VA+ Sbjct: 236 HLEQVKTQLKRNPKELPKLIIKN--KNIFEINFEDIELVDYEFDPIIKGEVAV 286 >UniRef50_Q9UTI7 Probable thymidylate synthase n=17 Tax=cellular organisms RepID=TYSY_SCHPO Length = 625 Score = 326 bits (837), Expect = 3e-88, Method: Composition-based stats. Identities = 127/295 (43%), Positives = 178/295 (60%), Gaps = 32/295 (10%) Query: 2 KQYLELMQKVLDEGTQKNDRTGTGTLSIF-GHQMRFNLQDG-FPLVTTKRCHLRSIIHEL 59 +QYL L++ +L+ G + DRTGTGT S+F Q+RF+L++ PL+TTKR LR ++ EL Sbjct: 331 EQYLNLIRYILENGQSRPDRTGTGTRSVFAPPQLRFSLRNNTLPLLTTKRVFLRGVLEEL 390 Query: 60 LWFLQGDTNIAYLHENNVTIWDEWADEN------------GDLGPVYGKQWRAW------ 101 LWF+ GDTN +L E + IWD GDLGP+YG QWR + Sbjct: 391 LWFIHGDTNANHLSEKGIHIWDGNGSREFLDSRGLTDRKVGDLGPIYGFQWRHFGAQYVD 450 Query: 102 --PTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVAD--- 156 + +DQ+ V++ LK +P RRII+SAWN + +MAL PCH F QFYV++ Sbjct: 451 CDTDYTNKGVDQLAQVISTLKLNPYDRRIILSAWNPLAIPEMALPPCHIFCQFYVSEPCK 510 Query: 157 --GK--LSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNH 212 GK LS +YQRS D+ LG+PFNIASY+LL HM+A C E +FV GD H+Y++H Sbjct: 511 PGGKPQLSSMMYQRSADMGLGVPFNIASYSLLTHMIAHMCGYEAAEFVHVMGDCHIYNDH 570 Query: 213 MDQTHLQLSREPRPLPKLIIKRKPE---SIFDYRFEDFEIEGYDPHPGIKAPVAI 264 ++ QL R P+ PKL KR + SI + +DF +EGY+P+ IK +++ Sbjct: 571 LEALQTQLERVPKAFPKLFFKRDAKDIGSIDSFSVDDFAVEGYNPYGPIKMKMSV 625 >UniRef50_B1C3H3 Thymidylate synthase n=6 Tax=Bacteria RepID=B1C3H3_9FIRM Length = 295 Score = 324 bits (832), Expect = 1e-87, Method: Composition-based stats. Identities = 144/298 (48%), Positives = 191/298 (64%), Gaps = 37/298 (12%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL 60 MKQYLE+ + VL+ G ++DRTGTGT S+FG+Q R++L+DGFPL+TTK+ +R I ELL Sbjct: 1 MKQYLEMCKYVLENGEDRSDRTGTGTRSVFGYQTRYDLRDGFPLMTTKKMFIRPIAEELL 60 Query: 61 WFLQGDTNIAYLHENNVTIWDEWADEN--------------------------------G 88 WF++GDTNI YL + NV IW+EW EN G Sbjct: 61 WFIKGDTNIKYLVDRNVKIWNEWPYENYKKSKDYQGETIEEFIEKIKNLPEDDSFVLKYG 120 Query: 89 DLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHA 148 DLGPVYG QWR + + +DQ+ +++ LKNDP SRR I+ AWN ++D M L PCHA Sbjct: 121 DLGPVYGAQWRNF---NYEGVDQLAKLVDSLKNDPFSRRHIICAWNPAQVDNMTLPPCHA 177 Query: 149 FFQFYVADGK--LSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDT 206 F QFYV+ K LSCQLYQRS D+FLG+PFNIASYAL+V M+A+ C E +FV T GD Sbjct: 178 FLQFYVSADKKYLSCQLYQRSADIFLGVPFNIASYALMVEMLARTCGYEAKEFVHTIGDA 237 Query: 207 HLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 H+Y +H D QL R+P P KL++ + +SIFDY+ ED +IE Y + + V++ Sbjct: 238 HIYKDHFDVVKQQLERKPLPKCKLVLNPEVKSIFDYKIEDIKIEDYQSYGKLVGKVSV 295 >UniRef50_Q0FG99 Thymidylate synthase n=4 Tax=root RepID=Q0FG99_9RHOB Length = 292 Score = 321 bits (823), Expect = 2e-86, Method: Composition-based stats. Identities = 145/293 (49%), Positives = 189/293 (64%), Gaps = 30/293 (10%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL 60 MKQYL+ + ++D G + +DRTG GTLS+FG+Q+RFNLQ+GFP VTTK+ RSI+ ELL Sbjct: 1 MKQYLDALNYIMDNGEEVSDRTGVGTLSVFGYQIRFNLQEGFPAVTTKKLAWRSIVGELL 60 Query: 61 WFLQGDTNIAYLHE-----------NNVTIWDEWADENG------------DLGPVYGKQ 97 WFL+G T+ L E + TIW AD G +LGPVYG Q Sbjct: 61 WFLEGSTDERRLAELTFNKDRTDLVHKKTIWTANADAQGAELGYENNDLIKELGPVYGHQ 120 Query: 98 WRAWPTPDGR---HIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYV 154 WR + D DQI ++N++KN+PDSRR+I+SAWN ++++MAL PCH QF V Sbjct: 121 WRHFDGTDKDISLSTDQIIWLINEIKNNPDSRRMILSAWNPNQINEMALPPCHTMAQFRV 180 Query: 155 ADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMD 214 +GKLSCQLYQRS D+FLG+PFNIASY+LL HM+AQ CDL+VG FVW GGD H+Y NH Sbjct: 181 MNGKLSCQLYQRSADMFLGVPFNIASYSLLTHMLAQLCDLKVGSFVWVGGDCHIYKNHKK 240 Query: 215 QTHLQLSREPRPLPKLIIKRKPESIFDY---RFEDFEIEGYDPHPGIKAPVAI 264 Q QL R P+ LP L + ++ + R + ++ YDP IKAP+AI Sbjct: 241 QVLEQLKRTPKSLPNLEM-PSFSNLDELLQTRPIGYVLKNYDPMDSIKAPMAI 292 >UniRef50_Q76YC2 DTMP synthase n=1 Tax=Aeromonas phage Aeh1 RepID=Q76YC2_9CAUD Length = 277 Score = 315 bits (808), Expect = 7e-85, Method: Composition-based stats. Identities = 117/282 (41%), Positives = 160/282 (56%), Gaps = 23/282 (8%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL 60 MK YL+++ + G + DRTG GT S+ G R ++ DGFP VTTK +++ E L Sbjct: 1 MKAYLDIINYTFENGEDEMDRTGVGTRSVLGQVFRHDMADGFPAVTTKTLAWKAVRGECL 60 Query: 61 WFLQGDTNIAYLHENN-------VTIWDEWAD--------ENGDLGPVYGKQWRAWPTPD 105 WF+ G TN+ L TIWD+ + +G+LGPVYGKQWR + Sbjct: 61 WFMNGFTNVEVLRAMTYGVGSSSKTIWDDNFNHQGVALGYTDGELGPVYGKQWRDFN--- 117 Query: 106 GRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQ 165 +DQ+ + ++K +P+ RR IV AWN +LDKMAL PCH F+F V G+L+ YQ Sbjct: 118 --GVDQLAKAIERIKTNPECRRNIVCAWNPVDLDKMALPPCHVLFRFSVKRGRLNLTWYQ 175 Query: 166 RSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPR 225 RS D FLGLPFNIASY LL+ ++AQ + G DTH+Y NH +Q QL REP Sbjct: 176 RSVDTFLGLPFNIASYGLLLEIVAQITGYKAGILTGMLDDTHIYHNHFEQVQEQLQREPH 235 Query: 226 PLPKLIIKRKPESIFD---YRFEDFEIEGYDPHPGIKAPVAI 264 LP L K + ++ + +D E+E Y H IKAP+A+ Sbjct: 236 KLPTLKFKNRFTTLEEACNLSVDDIELEDYKCHSAIKAPMAV 277 >UniRef50_P00471 Thymidylate synthase n=17 Tax=T4-like viruses RepID=TYSY_BPT4 Length = 286 Score = 311 bits (796), Expect = 2e-83, Method: Composition-based stats. Identities = 128/291 (43%), Positives = 181/291 (62%), Gaps = 32/291 (10%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL 60 MKQY +L++ + + G + +DRTGTGT+++FG ++R++L GFP VTTK+ ++ I EL+ Sbjct: 1 MKQYQDLIKDIFENGYETDDRTGTGTIALFGSKLRWDLTKGFPAVTTKKLAWKACIAELI 60 Query: 61 WFLQGDTNIAYLHE-------NNVTIWDEWADEN--------GDLGPVYGKQWRAWPTPD 105 WFL G TN+ L T+WDE + G+LGP+YGKQWR + Sbjct: 61 WFLSGSTNVNDLRLIQHDSLIQGKTVWDENYENQAKDLGYHSGELGPIYGKQWRDF---- 116 Query: 106 GRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQ 165 +DQI V++++K P+ RR IVSAWN EL MAL PCH F+QF V +G L Q YQ Sbjct: 117 -GGVDQIIEVIDRIKKLPNDRRQIVSAWNPAELKYMALPPCHMFYQFNVRNGYLDLQWYQ 175 Query: 166 RSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPR 225 RS DVFLGLPFNIASYA LVH++A+ C+L GD +++GG+TH+Y NH++Q L REP+ Sbjct: 176 RSVDVFLGLPFNIASYATLVHIVAKMCNLIPGDLIFSGGNTHIYMNHVEQCKEILRREPK 235 Query: 226 PLPKLII------------KRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 L +L+I K + + + R +DF + Y HP IK +A+ Sbjct: 236 ELCELVISGLPYKFRYLSTKEQLKYVLKLRPKDFVLNNYVSHPPIKGKMAV 286 >UniRef50_Q8WYK3 Thymidylate synthase n=4 Tax=Eutheria RepID=Q8WYK3_HUMAN Length = 279 Score = 309 bits (793), Expect = 5e-83, Method: Composition-based stats. Identities = 129/274 (47%), Positives = 164/274 (59%), Gaps = 38/274 (13%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62 QYL +Q +L G +K+DRTGTGTLS+FG Q R++L+D FPL+TTKR + ++ ELLWF Sbjct: 32 QYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWF 91 Query: 63 LQGDTNIAYLHENNVTIWDEWADEN------------GDLGPVYGKQWRAWPTPDGRHID 110 ++G TN L V IWD + GDLGPVYG QWR + Sbjct: 92 IKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEGDLGPVYGFQWRHFGAEYRDME- 150 Query: 111 QITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDV 170 +L MAL PCHA QFYV + +LSCQLYQRS D+ Sbjct: 151 -------------------------SDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDM 185 Query: 171 FLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKL 230 LG+PFNIASYALL +M+A L+ GDF+ T GD H+Y NH++ +QL REPRP PKL Sbjct: 186 GLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKL 245 Query: 231 IIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 I RK E I D++ EDF+IEGY+PHP IK +A+ Sbjct: 246 RILRKVEKIDDFKAEDFQIEGYNPHPTIKMEMAV 279 >UniRef50_Q3J0W9 Thymidylate synthase n=12 Tax=Bacteria RepID=TYSY_RHOS4 Length = 298 Score = 309 bits (792), Expect = 6e-83, Method: Composition-based stats. Identities = 138/293 (47%), Positives = 182/293 (62%), Gaps = 30/293 (10%) Query: 2 KQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDG-FPLVTTKRCHLRSIIHELL 60 +QYL+L+ + L+ G ++ DRTG GTLS+FG +RF+L G P++TTKR + ++ + E+L Sbjct: 6 QQYLDLLAQTLERGDRRVDRTGVGTLSLFGAMLRFDLSGGQVPILTTKRVYWKTAVKEML 65 Query: 61 WFLQGDTNIAYLHENNVTIWDEW----------------------------ADENGDLGP 92 WFL G TNI L + NV IW +W A G+LGP Sbjct: 66 WFLTGGTNIRPLLQENVRIWSDWPLAAYRRESGEEISQAAFEQRVLEDEAFAARWGELGP 125 Query: 93 VYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQF 152 VYGKQWR W PDG DQI ++ L+ +P SRR++ AWNV E+ +MAL PCH +Q+ Sbjct: 126 VYGKQWRRWLGPDGHEHDQIAALIETLRTNPSSRRMLFHAWNVAEVGQMALPPCHMVYQY 185 Query: 153 YV-ADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSN 211 +V +DG+L+ LYQRS D+ LG PFN A L M+AQQ L GD VW GGDTHLY N Sbjct: 186 HVTSDGRLNALLYQRSVDLLLGAPFNFVGAAALQLMIAQQAGLVPGDLVWVGGDTHLYLN 245 Query: 212 HMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 H+DQ Q R PR P++ + R+ +SI DYR EDF +EGYDPHP I A VA+ Sbjct: 246 HLDQAREQTGRAPRDWPRMRLLRRADSIDDYRIEDFAVEGYDPHPAIAAEVAV 298 >UniRef50_Q4PBV6 Thymidylate synthase n=3 Tax=Dikarya RepID=Q4PBV6_USTMA Length = 554 Score = 309 bits (791), Expect = 7e-83, Method: Composition-based stats. Identities = 127/295 (43%), Positives = 181/295 (61%), Gaps = 33/295 (11%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQ--MRFNLQDG-FPLVTTKRCHLRSIIHEL 59 QYLEL+Q+V+ G + DRTGTGTL++F Q +RF+L +G PL+TTKR R ++ EL Sbjct: 260 QYLELVQRVISTGESRPDRTGTGTLALFAPQPSLRFDLTNGTLPLLTTKRVFFRGVLEEL 319 Query: 60 LWFLQGDTNIAYLHENNVTIWDEWADE------------NGDLGPVYGKQWRAW------ 101 LWF+ G T+ L E +V IWD GDLGPVYG QWR + Sbjct: 320 LWFVGGKTDAKLLTEKSVHIWDGNGSRAFLDSRGLSHRREGDLGPVYGFQWRHFGATYKD 379 Query: 102 --PTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVAD--- 156 G+ +DQ+ +V+++++N+P RRI++SAWN +L+ MAL PCH F QF+V++ Sbjct: 380 CDTDYAGQGVDQLASVIDKIRNNPTDRRILLSAWNPADLELMALPPCHMFAQFFVSNLDA 439 Query: 157 -------GKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLY 209 LSCQ+YQRSCD+ LG+PFNIASYALL +M+A+ D E + + GD H+Y Sbjct: 440 YSKGQGKKHLSCQMYQRSCDLGLGVPFNIASYALLTYMIAKVTDCEPKELILAMGDAHVY 499 Query: 210 SNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 +H+ QL R+P P PKL I+R + I D+ F+DF ++GY H I +++ Sbjct: 500 KDHVQPLKAQLERDPLPFPKLKIERDVKDIDDFTFDDFVVQGYKCHGKIDMKMSV 554 >UniRef50_A2R2F6 Thymidylate synthase n=20 Tax=Leotiomyceta RepID=A2R2F6_ASPNC Length = 356 Score = 308 bits (790), Expect = 1e-82, Method: Composition-based stats. Identities = 129/318 (40%), Positives = 172/318 (54%), Gaps = 56/318 (17%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIF-GHQMRFNLQDG--------------FPLVTT 47 QYL L++++L EG + DRTGTGT SIF QMRF+L PL+TT Sbjct: 39 QYLNLIRRILSEGEHRPDRTGTGTRSIFAPPQMRFSLSKPSTNTTTGIKEYTPILPLLTT 98 Query: 48 KRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADEN------------GDLGPVYG 95 KR LR+++ ELLWF+ G T+ L E + IWD GDLGPVYG Sbjct: 99 KRVFLRAVLAELLWFISGTTSSLPLSEAGIKIWDGNGSREYLDKVGLSHREVGDLGPVYG 158 Query: 96 KQWRAW--------PTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCH 147 QWR + G+ +DQ+ V+ +LK +P RRII+SAWN ++ MAL PCH Sbjct: 159 FQWRHFGAEYVDAKTDYSGQGVDQLAEVVKKLKENPFDRRIIMSAWNPKDMRIMALPPCH 218 Query: 148 AFFQFYVA------------------DGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMA 189 F QFYV G L C LYQRS D+ LG+PFNIASYALL H++A Sbjct: 219 MFAQFYVRFPDAKRDEEGVVRDGEWGRGHLDCLLYQRSADMGLGVPFNIASYALLTHLLA 278 Query: 190 QQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPES---IFDYRFED 246 D+ G V T GD H+Y +H+D Q+ REP P++ IKR+ + ++ E+ Sbjct: 279 HAVDMVPGTLVHTLGDAHVYLDHVDALKEQIEREPVAFPEVRIKREDRGSGVVDGWKEEE 338 Query: 247 FEIEGYDPHPGIKAPVAI 264 FE+ GY PH IK +++ Sbjct: 339 FEVIGYKPHKAIKMKMSV 356 >UniRef50_Q04FR4 Thymidylate synthase n=279 Tax=cellular organisms RepID=TYSY_OENOB Length = 319 Score = 306 bits (784), Expect = 6e-82, Method: Composition-based stats. Identities = 133/314 (42%), Positives = 180/314 (57%), Gaps = 51/314 (16%) Query: 2 KQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLW 61 +QYL L +++L+ G K DRT TGT SIFG QMRF+L +GFPL+T+K+ I ELLW Sbjct: 6 EQYLNLARRILETGASKMDRTKTGTHSIFGAQMRFDLSEGFPLLTSKKVAFGRIKSELLW 65 Query: 62 FLQGDTNIAYLHENNVTIWDEWADEN---------------------------------- 87 FL+GD NI +L +++ IWDEW + Sbjct: 66 FLRGDNNIRFLLQHHNHIWDEWPFKKWVESNEYKGPDMTDFGLRTQKDPIFAEQYKEQKK 125 Query: 88 ----------------GDLGPVYGKQWRAWPTPDGRH-IDQITTVLNQLKNDPDSRRIIV 130 G +G VYGK WR WP + +DQIT ++N++K +P+SRR+I+ Sbjct: 126 IFVDRILNDDEFSKKFGTIGDVYGKLWRHWPDANDDGSVDQITRLINEIKVNPNSRRLIL 185 Query: 131 SAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQ 190 +AW+ L CH QFYV DGK+S Q+YQRS D FLG+PFNIASY+LL+ M+A Sbjct: 186 TAWDPETTPFATLPSCHVMSQFYVVDGKISLQMYQRSADYFLGVPFNIASYSLLLSMVAA 245 Query: 191 QCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIE 250 Q LEVG+F+ T GD H+Y+NH+DQ QLS+ LP L + +SIFDY D ++E Sbjct: 246 QTGLEVGEFIHTIGDAHIYNNHVDQIKEQLSKPTHKLPTLKLNPDVKSIFDYEMSDIKLE 305 Query: 251 GYDPHPGIKAPVAI 264 Y IKAP+A+ Sbjct: 306 NYIHEDVIKAPIAV 319 >UniRef50_A5KSZ1 Thymidylate synthase n=1 Tax=candidate division TM7 genomosp. GTL1 RepID=A5KSZ1_9BACT Length = 280 Score = 305 bits (781), Expect = 1e-81, Method: Composition-based stats. Identities = 123/273 (45%), Positives = 168/273 (61%), Gaps = 11/273 (4%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62 QYL+LM +L +G K R G +IFG+Q+RF+++ GFPL+TTK+ + ++HEL WF Sbjct: 7 QYLQLMADILKDGRSKPSRGIHGLKAIFGYQIRFDMRQGFPLLTTKKMPFKILLHELFWF 66 Query: 63 LQGDTNIAYLHENNVTIWDEWADEN-GDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKN 121 + G +++ YLHE+ + WD + E DLG VYG QWR W PDG DQ+ + Q+K Sbjct: 67 ISGSSSVDYLHEHKIHYWDGFLHEGSDDLGRVYGVQWRHWLRPDGSQFDQLQWAIEQIKT 126 Query: 122 DPDSRRIIVSAWN----------VGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVF 171 +P+S+ IIVSAWN + M L PCH FQF V GKL QLYQRS DVF Sbjct: 127 NPNSKAIIVSAWNAGELGDKRWNPNDYGDMRLPPCHTMFQFDVTGGKLRMQLYQRSSDVF 186 Query: 172 LGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLI 231 LGLPFNIA YA+L+HM+A DLE + + + G HLY N ++ Q+ R+P PKL Sbjct: 187 LGLPFNIAQYAMLLHMVAYLADLEPRELIISIGSAHLYRNQIEPAKEQVRRKPYRFPKLT 246 Query: 232 IKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 I + I D++ ++F +EGY HP IK + I Sbjct: 247 IAGDVKDIDDFKEKNFSLEGYQSHPHIKTDLVI 279 >UniRef50_Q2G6V6 Thymidylate synthase n=14 Tax=Bacteria RepID=TYSY_NOVAD Length = 314 Score = 303 bits (776), Expect = 4e-81, Method: Composition-based stats. Identities = 140/301 (46%), Positives = 185/301 (61%), Gaps = 39/301 (12%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGF-PLVTTKRCHLRSIIHELLW 61 QYL+LM+++ + G ++ DRTG GT S+FG ++RF+L DG PL+TTKR + ++ E LW Sbjct: 14 QYLDLMRRIWEHGDERVDRTGVGTRSVFGAELRFDLSDGRMPLLTTKRVYWKTATREFLW 73 Query: 62 FLQGDTNIAYLHENNVTIWDEWADEN----------------------------GDLGPV 93 FL G+TNI L V IW +W + GDLGPV Sbjct: 74 FLTGNTNIRPLCAQGVEIWTDWPLDRYRKETGDDISRKDFSARIVADEAFALRWGDLGPV 133 Query: 94 YGKQWRAWP----------TPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMAL 143 YGKQW WP ++Q+ V++ L+++P SRR I+ WNV E+D+MAL Sbjct: 134 YGKQWVDWPVFEPVGDGLFRRREAGVNQVADVVDSLRHNPGSRRHIIEGWNVAEIDRMAL 193 Query: 144 APCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTG 203 PCH +QF+V+ +L+ LYQRSCDV LGLPFN+ ALLV ++AQQCDL+ G+ VW G Sbjct: 194 PPCHKTYQFHVSGNRLNGLLYQRSCDVALGLPFNLWGAALLVRLLAQQCDLQPGELVWMG 253 Query: 204 GDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263 GDTHLY NH D QLSREP P+L I R+P+SIF YR EDFE+ GY P + APVA Sbjct: 254 GDTHLYLNHADLVEAQLSREPEGDPRLAILRRPDSIFGYRIEDFEVTGYAPQGHLSAPVA 313 Query: 264 I 264 + Sbjct: 314 V 314 >UniRef50_Q6QGJ5 Putative thymidylate synthase n=1 Tax=Enterobacteria phage T5 RepID=Q6QGJ5_BPT5 Length = 279 Score = 299 bits (767), Expect = 5e-80, Method: Composition-based stats. Identities = 134/284 (47%), Positives = 182/284 (64%), Gaps = 27/284 (9%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL 60 M+QYL+++ V+ G +NDRTGTGT+SIF +F+L++GFP VTTKR +S++ ELL Sbjct: 1 MQQYLKILTDVILLGEPRNDRTGTGTVSIFDSYAKFDLREGFPAVTTKRLAWKSVVGELL 60 Query: 61 WFLQGDTNIAYLH-------ENNVTIWDEWADE--------NGDLGPVYGKQWRAWPTPD 105 WFL G TN+ L E TIW ++ G+LGPVYGKQWR + Sbjct: 61 WFLSGSTNLHDLRVFTFGRDEGQWTIWTPNYEDQAISMGYDKGNLGPVYGKQWRNF---- 116 Query: 106 GRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVA-DGKLSCQLY 164 DQI ++ LKN+P RR +VSAWNV ELDKMAL PCH FQ YV+ DG L + Sbjct: 117 -GGRDQILELIEGLKNNPHGRRHLVSAWNVAELDKMALPPCHYGFQCYVSNDGYLDLKWT 175 Query: 165 QRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREP 224 QRS D FLGLPFNIASYALL H++A+ L+ +++GGDTH+Y++HM+Q Q+ R+P Sbjct: 176 QRSVDCFLGLPFNIASYALLTHILAKLTGLKPRYLIFSGGDTHIYNDHMEQVEEQVKRKP 235 Query: 225 RPLPKLIIKRKPESIFDYRFED-----FEIEGYDPHPGIKAPVA 263 RPLP L++ + ++D + F +EGYDPHP +KA ++ Sbjct: 236 RPLPTLVM-PEFVDLYDLLENNTAAWSFHLEGYDPHPALKAKMS 278 >UniRef50_D2XB64 Bifunctional dihydrofolate reductase-thymidylate synthase n=1 Tax=Marseillevirus RepID=D2XB64_9VIRU Length = 444 Score = 299 bits (765), Expect = 8e-80, Method: Composition-based stats. Identities = 113/281 (40%), Positives = 162/281 (57%), Gaps = 20/281 (7%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRF-NLQDGFPLVTTKRCHLRSIIHELLW 61 YL L+ +VL G ++ DRTGTGT S+FG + F N+ + FPL+T KR I+ ELLW Sbjct: 163 AYLSLLSEVLYSGEKRKDRTGTGTRSLFGRHLLFENISEKFPLITVKRMAWGCILSELLW 222 Query: 62 FLQGDTNIAYLHENNVTIWDEWADE-----------NGDLGPVYGKQWRAW--------P 102 FL G T+ L N IW + + GD GP+YG QWR W Sbjct: 223 FLSGSTDSKMLELQNNNIWKKNSSRKFLDGRGLSYREGDCGPIYGFQWRHWGAKYVDCDT 282 Query: 103 TPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQ 162 G+ DQI +++++++N+ SRR+++SAWNV +LDKM L PCH+F QFYV + C Sbjct: 283 DYRGQGEDQILSIISEIQNNATSRRLVLSAWNVSDLDKMCLPPCHSFSQFYVRGDFVDCH 342 Query: 163 LYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSR 222 LYQRS D+ LG+PFNIASYA L+ ++A+ + G+ + GD H+Y H+D L R Sbjct: 343 LYQRSADLALGVPFNIASYACLLSIIAEASGKKAGNLTMSFGDVHIYETHIDNAQKMLER 402 Query: 223 EPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263 P PKL +K ++F + DFE++GY ++ +A Sbjct: 403 LPHKTPKLKVKISDNTLFCLKKGDFELDGYSCCGALQFDMA 443 >UniRef50_D1BNV6 Thymidylate synthase n=4 Tax=Veillonellaceae RepID=D1BNV6_VEIPT Length = 263 Score = 298 bits (764), Expect = 1e-79, Method: Composition-based stats. Identities = 101/265 (38%), Positives = 151/265 (56%), Gaps = 11/265 (4%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62 QYL +++ +LD G +RTG T + M+F+LQ+ FP++TTK ++ + ELLW Sbjct: 7 QYLGIIENILDHGIYGQNRTGIATYKLPQQIMQFDLQEEFPILTTKFVAFKTAVKELLWI 66 Query: 63 LQ-GDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKN 121 Q ++ L E NV +WDEW E+G +G YG Q + Q+ ++ +K Sbjct: 67 WQMQSNDVRKLQEMNVHVWDEWMREDGTIGKAYGYQIAKYK--------QLDKLIKTIKE 118 Query: 122 DPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASY 181 DPDSRR+IV+ WN+ +LD MAL PC + V DG L+C L QRS D+ LG+PFN A Y Sbjct: 119 DPDSRRMIVTLWNIEDLDDMALQPCAYETLWDVGDGYLNCMLIQRSGDMGLGVPFNTAQY 178 Query: 182 ALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSR--EPRPLPKLIIKRKPESI 239 A L M+AQ L+ G F + H+Y NH+D QL+R + P PK+I+ + + Sbjct: 179 AALQCMIAQVTGLKPGKFTHVINNAHIYENHVDALREQLARRNQALPAPKIIVNPEVKDF 238 Query: 240 FDYRFEDFEIEGYDPHPGIKAPVAI 264 +D+ ED ++GY+ + VA+ Sbjct: 239 YDFTPEDITLDGYEHLGKLSMTVAV 263 >UniRef50_Q65J44 Thymidylate synthase n=9 Tax=root RepID=TYSY_BACLD Length = 279 Score = 292 bits (747), Expect = 9e-78, Method: Composition-based stats. Identities = 97/275 (35%), Positives = 157/275 (57%), Gaps = 13/275 (4%) Query: 2 KQYLELMQKVLDEGT----------QKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCH 51 +QY ++QK+++ G +D T TLSI +MRF+ + P++TTK+ Sbjct: 6 QQYNAIIQKIIESGISDEEYQVRTKWDSDGTPAHTLSIMSEKMRFDNSE-VPILTTKKVA 64 Query: 52 LRSIIHELLWFLQ-GDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTP-DGRHI 109 ++ I ELLW Q ++ L++ V IWD+W E+G +G YG Q +G+ + Sbjct: 65 WKTAIKELLWIWQLKSNDVQVLNDMGVHIWDQWRLEDGTIGAAYGYQLGKKNRTVNGQKV 124 Query: 110 DQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCD 169 DQ+ +L+QLK++P SRR + WN +LD MAL PC Q+YV +GKLS ++ RS D Sbjct: 125 DQVDYLLHQLKHNPSSRRHLTMLWNPDDLDGMALTPCVYETQWYVKEGKLSLEVRARSND 184 Query: 170 VFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPK 229 + LG PFN+ Y +L M+AQ E+G++++ GD H+Y+ H+D ++Q+ RE PK Sbjct: 185 MALGNPFNVFQYNVLQRMIAQVLGYELGEYIFNIGDCHIYTRHIDNLNIQMKREQYEAPK 244 Query: 230 LIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 L I ++ +D+ +DF++ Y + VA+ Sbjct: 245 LWINPDIKNFYDFTIDDFKLIDYKHGDKLTFEVAV 279 >UniRef50_A3QU09 Thymidylate synthase n=1 Tax=Oryctes rhinoceros virus RepID=A3QU09_9VIRU Length = 321 Score = 291 bits (746), Expect = 1e-77, Method: Composition-based stats. Identities = 119/293 (40%), Positives = 168/293 (57%), Gaps = 31/293 (10%) Query: 2 KQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDG-FPLVTTKRCHLRSIIHELL 60 + YL L++ VL + +RTG S FGHQ+RF+L++G PL+TTK ++I+ EL Sbjct: 30 RNYLSLVRTVLKAPSS-PNRTGIDARSSFGHQLRFDLRNGVLPLLTTKPMPFKTILRELF 88 Query: 61 WFLQGDTNIAYLHENNVTIWDEWADENG-------------DLGPVYGKQWRAW------ 101 WFL+G+TN L NV IW + LGP+YG QWR + Sbjct: 89 WFLRGETNQKILERQNVHIWKGNSSREYLDSRGLYDYTEYESLGPIYGFQWRHFGASYVD 148 Query: 102 --PTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVA--DG 157 + +DQ+ V+ +K DP SRRII+SAWN +LDKMAL PCH QF+V +G Sbjct: 149 CNTDYTNKGVDQLQQVIRTIKEDPTSRRIIMSAWNPVDLDKMALPPCHILVQFHVNTVNG 208 Query: 158 KLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTH 217 +LS QLYQRS D+ LG+PFNIASY++LVH++A+ C L+ G F+ + GD H+Y NH+ Sbjct: 209 ELSAQLYQRSADLMLGVPFNIASYSILVHLIAKICGLKPGYFIHSLGDVHIYENHVSGAK 268 Query: 218 LQLSREPRPLPKLIIKRKPES-----IFDYRFEDFEIEGYDPHP-GIKAPVAI 264 QL+REP+ P L I P + + F++ Y +P IK +A+ Sbjct: 269 EQLTREPQRQPYLNIDIDPTLDLDSILEQLSCDQFKLVNYKYNPNPIKLEMAV 321 >UniRef50_A6M378 Thymidylate synthase n=8 Tax=Clostridium RepID=TYSY_CLOB8 Length = 263 Score = 283 bits (724), Expect = 5e-75, Method: Composition-based stats. Identities = 96/265 (36%), Positives = 147/265 (55%), Gaps = 11/265 (4%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62 +YL + +L+ G N+RTG T + M+FNL+ FP++TTK ++ + ELLW Sbjct: 7 KYLAIANDILENGYFDNNRTGVKTYKLPHQIMQFNLEKEFPILTTKFVAFKTAVKELLWI 66 Query: 63 LQ-GDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKN 121 + ++ L NV IWDEW E+G +G YG + + DQI +++ LKN Sbjct: 67 FKDQSNSVKELQSQNVKIWDEWMMEDGTIGTSYGWIVKKF--------DQIDKLIDALKN 118 Query: 122 DPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASY 181 +P RR++++ W + LD L PC + V DGKL+C L QRS D LG+PFN + Y Sbjct: 119 NPQDRRMMINLWQIPYLDSAPLYPCCFLTMWDVTDGKLNCMLVQRSGDWGLGVPFNTSQY 178 Query: 182 ALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSRE--PRPLPKLIIKRKPESI 239 A+LVH++AQ L+ G F + H+Y N +D LQL+R+ PKL I + + Sbjct: 179 AVLVHLLAQVTGLKPGLFTHVINNAHIYENQVDGLKLQLTRKNDAYNAPKLWINPEITNF 238 Query: 240 FDYRFEDFEIEGYDPHPGIKAPVAI 264 +D+ +D ++E Y H IK V++ Sbjct: 239 YDFTPDDIKLEDYKHHESIKMDVSV 263 >UniRef50_B2YFY9 Thymidylate synthase n=1 Tax=Musca domestica salivary gland hypertrophy virus RepID=B2YFY9_9VIRU Length = 294 Score = 282 bits (722), Expect = 7e-75, Method: Composition-based stats. Identities = 106/284 (37%), Positives = 167/284 (58%), Gaps = 24/284 (8%) Query: 4 YLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFP-LVTTKRCHLRSIIHELLWF 62 YL L+++VL +GT K++RTG T IFG Q+R++L+D ++TTK+ RS + ELLWF Sbjct: 10 YLTLVRRVLRDGTLKSNRTGVDTKYIFGDQLRYDLRDNRIAMLTTKKVFFRSALEELLWF 69 Query: 63 LQGDTNIAYLHENNVTIWDEWADENG------------DLGPVYGKQWRAW--------P 102 L+GDTN A L V IW + LGP+YG QWR + Sbjct: 70 LRGDTNQANLAAKGVNIWRGNSTREYLDSRKLPYPEHESLGPIYGFQWRHFGARYIDCHT 129 Query: 103 TPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVAD--GKLS 160 G+ +DQ+ ++Q++ +P SRR+I++AWN +LDKM L PCH QF V + G+LS Sbjct: 130 DYTGQGVDQLAQCMHQIQYEPSSRRMIMTAWNPNDLDKMVLPPCHMSIQFSVNEKLGELS 189 Query: 161 CQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQL 220 + QRS D+ LG+PFN+ SY+L++H++A + L+ G+ V + GD H+Y H+ Q+ Sbjct: 190 GHMTQRSADLMLGVPFNLVSYSLMLHILAHKFGLKAGELVTSYGDLHIYVPHIKNAMRQV 249 Query: 221 SREPRPLPKLIIK-RKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263 SR P P++ +K + + + + +DF ++ Y H ++ +A Sbjct: 250 SRLPYASPQIELKFGRDKRVEELTVDDFAVKNYRHHSQLEYEMA 293 >UniRef50_Q88CN9 Thymidylate synthase n=74 Tax=Proteobacteria RepID=TYSY_PSEPK Length = 323 Score = 275 bits (704), Expect = 8e-73, Method: Composition-based stats. Identities = 113/323 (34%), Positives = 162/323 (50%), Gaps = 59/323 (18%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL 60 MKQYL+L++ V+D GT + +RTG T+S+ G +RF+LQ GFP +TT++ +S I E++ Sbjct: 1 MKQYLDLVRDVIDNGTLQGNRTGIRTISLPGAMLRFDLQKGFPAITTRKLAFKSAIGEMV 60 Query: 61 WFLQGDTNIAYLHENNVTIWDEWADEN------------GDLGPVYGKQWRAWPTPD--- 105 FL+G N E +WD+ A+EN DLG +YG QWR WP Sbjct: 61 GFLRGVKNAGEFRELGCKVWDQNANENAQWLANPFRQGHDDLGEIYGVQWRQWPGYKRIP 120 Query: 106 -------------------------------GRHIDQITTVLNQLKNDPDSRRIIVSAWN 134 + IDQ+ L+ + NDP SRRI+ WN Sbjct: 121 LSNPAAIEMAEQAGFRRIAQDEEDGVAFVILYKAIDQVRQCLDTIANDPGSRRILFHGWN 180 Query: 135 VGELDKMALAPCHAFFQFY--VADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQC 192 +LD+MAL PCH +QF+ V ++S LY RS D+ LG PFN+ A L+ + + Sbjct: 181 CAQLDEMALPPCHLLYQFHPNVETREISLTLYIRSNDLGLGTPFNLTEGAALLSLFGRLT 240 Query: 193 DLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKR-----------KPESIFD 241 F + GD H+Y NH+D + QL REP PKL+I +PE + Sbjct: 241 GYTPRWFTYFIGDAHVYENHLDMLNEQLKREPLEAPKLVISDRVPAFAETGKYEPEWLEK 300 Query: 242 YRFEDFEIEGYDPHPGIKAPVAI 264 DF +EGY+ H + AP+A+ Sbjct: 301 IEPSDFWLEGYEHHAPMTAPMAV 323 >UniRef50_A9UZA9 Thymidylate synthase n=1 Tax=Monosiga brevicollis RepID=A9UZA9_MONBE Length = 398 Score = 271 bits (693), Expect = 2e-71, Method: Composition-based stats. Identities = 111/243 (45%), Positives = 137/243 (56%), Gaps = 45/243 (18%) Query: 67 TNIAYLHENNVTIWDEWAD------------ENGDLGPVYGKQWRAW--------PTPDG 106 TN L +V IWD E GDLGPVYG QWR + G Sbjct: 34 TNANDLAARDVHIWDANGSKDFLEKQGLGHREEGDLGPVYGFQWRHFGAEYKDMHTDYSG 93 Query: 107 RHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQR 166 + +DQ+ V+ Q+K +PDSRRII+SAWN ++ KMAL PCH QFYV DG+LSCQLYQR Sbjct: 94 QGVDQLAEVIEQIKTNPDSRRIIMSAWNPLDIPKMALPPCHTMCQFYVCDGELSCQLYQR 153 Query: 167 SCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRP 226 S D+ LG+PFNIASYALL +M+AQ L+ GDFV T GD H+Y NH+D QL REPRP Sbjct: 154 SADMGLGVPFNIASYALLTYMIAQVTGLKPGDFVHTIGDAHVYLNHVDALEEQLKREPRP 213 Query: 227 LPKLIIKRKPES-------------------------IFDYRFEDFEIEGYDPHPGIKAP 261 P L KR E I D++FEDF+++GY PH I Sbjct: 214 FPTLSFKRDIEEYVHAFGQHVTNPLEHRPTAALLSLGIDDFKFEDFDLQGYKPHNRIAMD 273 Query: 262 VAI 264 +A+ Sbjct: 274 MAM 276 >UniRef50_Q5UQG3 Thymidylate synthase n=1 Tax=Acanthamoeba polyphaga mimivirus RepID=DRTS_MIMIV Length = 563 Score = 271 bits (693), Expect = 2e-71, Method: Composition-based stats. Identities = 108/292 (36%), Positives = 164/292 (56%), Gaps = 34/292 (11%) Query: 2 KQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLW 61 QY+EL++ ++++G K R T SIFG+Q++++L G+P+ T KR + ++I EL+W Sbjct: 273 NQYIELVKTIMEKGIVKQTRNSI-TKSIFGYQLKYDLSKGYPIQTIKRSYPKAIFEELMW 331 Query: 62 FLQGDTNIAYLHENNVTIWDEWAD-----------ENGDLGPVYGKQWRAW--------P 102 ++G T+++ L + V +WD+ + E GD+GP YG Q R W Sbjct: 332 MIRGQTDVSILQKKGVHVWDKNSSKDFLSKYNLPYEEGDIGPGYGFQMRYWGAEYTDCKT 391 Query: 103 TPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYV-------- 154 + G+ IDQ+ + ++N+P RRI+++ WN +LDKMALAPCH + F V Sbjct: 392 SYQGQGIDQLNKCIESIQNNPHDRRIMINLWNCSDLDKMALAPCHFCYMFGVDLYEVPTT 451 Query: 155 --ADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNH 212 G+L+C L QRS DV LG N + ALL +++A CDL+ G V + D H+Y +H Sbjct: 452 SGKKGRLNCHLVQRSWDVLLGW--NTTTAALLTYLIANHCDLDPGILVHSISDAHIYQSH 509 Query: 213 MD--QTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPV 262 +D L R+ R P L+I+ K E I DY F+D IE Y P P I A + Sbjct: 510 IDSGAISQLLQRKCRKFPNLVIRNKKEKIDDYEFDDLIIENYYPCPSISAEM 561 >UniRef50_A8RRN6 Thymidylate synthase n=16 Tax=Bacteria RepID=A8RRN6_9CLOT Length = 287 Score = 270 bits (691), Expect = 3e-71, Method: Composition-based stats. Identities = 90/273 (32%), Positives = 136/273 (49%), Gaps = 12/273 (4%) Query: 2 KQYLELMQKVLDEGTQK---------NDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHL 52 + +++ +L+ G D T T+ FG R++L FP++T +R Sbjct: 17 QIFIQNCNDILEHGVWDTDYDVRPVWEDGTPAHTIKRFGIVNRYDLTREFPVITLRRTAF 76 Query: 53 RSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQI 112 +S + ELLW Q +N +H+ N IWD WADENG +G YG Q DQ+ Sbjct: 77 KSAVDELLWIWQKKSN--NIHDLNSHIWDSWADENGSIGKAYGYQLGVKHHYKEGDFDQV 134 Query: 113 TTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFL 172 +L LK++P SRRI+ + +N +L +M L PC F V+ L+ L QRS D+ Sbjct: 135 DRILYDLKHNPLSRRIMSNIYNHHDLCEMNLYPCAYSMTFNVSGNTLNGILNQRSQDMLT 194 Query: 173 GLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLII 232 +N+ YA+L+HM+AQ L+ G+ V D H+Y H+ L REP P P L + Sbjct: 195 ANSWNVCQYAVLLHMLAQVSGLKPGELVHVIADAHIYDRHIPMVEELLKREPYPGPTLSM 254 Query: 233 KRKPESIFDYRFEDFEIEGYDPHP-GIKAPVAI 264 ++ + + + F +E Y H K PVAI Sbjct: 255 DTSIQNFYQFTTDSFRLEHYQYHTFSGKIPVAI 287 >UniRef50_Q6WIC0 DTMP (Thymidylate) synthase n=1 Tax=Vibrio phage KVP40 RepID=Q6WIC0_BPKV4 Length = 300 Score = 268 bits (686), Expect = 1e-70, Method: Composition-based stats. Identities = 115/300 (38%), Positives = 166/300 (55%), Gaps = 38/300 (12%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL 60 MK YL+L ++L+EG +RTGT T+S+ ++R++L GFPL+TTK+ ++I ELL Sbjct: 2 MKNYLQLCTEILNEGDFLENRTGTNTVSVISRELRWDLSKGFPLLTTKKMATKAIFGELL 61 Query: 61 WFLQGDTNIAYLHENN------VTIWDEWADE-------------NGDLGPVYGKQWRA- 100 WFL G I+ L + IW + DE DLG VYGK WR Sbjct: 62 WFLSGSGLISDLRKYTELSDEDFCIWQQNLDELNERAKKAGIVRNEDDLGYVYGKVWRKR 121 Query: 101 ------WPTPDGRHIDQITTVLNQLKNDPDS---RRIIVSAWNVGELDKM-----ALAPC 146 + I Q+ + +K DP RR+IV AW+ + AL PC Sbjct: 122 LSVTADKEVTEFDQIHQLLCDIAAVKEDPTQSAQRRMIVEAWDPYFHTESNSVDVALPPC 181 Query: 147 HAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDT 206 H FQ +V +GK+S + QRS D FLGLPFNIASYALLVH++AQ L+VG+ +++GGD Sbjct: 182 HYGFQVFVRNGKISLKWNQRSVDTFLGLPFNIASYALLVHILAQLTGLKVGELIFSGGDV 241 Query: 207 HLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDY---RFEDFEIEGYDPHPGIKAPVA 263 H+Y +H+ Q QL R PR LP++ + + +++ R DF + YDP+P +K ++ Sbjct: 242 HIYEDHIVQVLKQLRRTPRELPQIQL-PEFDTLSQLLTKRASDFVVYDYDPYPALKGKMS 300 >UniRef50_B6FSV1 Putative uncharacterized protein n=1 Tax=Clostridium nexile DSM 1787 RepID=B6FSV1_9CLOT Length = 282 Score = 268 bits (685), Expect = 2e-70, Method: Composition-based stats. Identities = 88/279 (31%), Positives = 142/279 (50%), Gaps = 18/279 (6%) Query: 2 KQYLELMQKVLDEGTQKN---------DRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHL 52 K ++++ + ++D G D + TL F R++L FP +T +R + Sbjct: 6 KVFIDMCRDIIDNGVSTEGEKVRPKWEDGSFAYTLKKFCVVNRYDLSKEFPALTLRRTGI 65 Query: 53 RSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQI 112 +S + ELLW Q +N +H+ IWD WADE+G +G YG Q +DQ+ Sbjct: 66 KSCVDELLWIWQRKSN--NVHDLKPHIWDSWADEDGSIGKAYGYQMSVKHQYKEGMMDQV 123 Query: 113 TTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGK------LSCQLYQR 166 V+ LKN+P SRRI+ + + +L +M L PC F V L+ L QR Sbjct: 124 DRVIYDLKNNPYSRRIMTNIYVHQDLHEMNLYPCAYSMTFNVTKKNDSDKLVLNGILNQR 183 Query: 167 SCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRP 226 S DV +N+ YA+L+HM+AQ CD++VG+FV D H+Y H+ +SREP P Sbjct: 184 SQDVLAANNWNVCQYAVLMHMLAQVCDMQVGEFVHVIADAHIYDRHIPLVEELISREPLP 243 Query: 227 LPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIK-APVAI 264 P + + ++ +++ +D ++ Y+ IK P+A+ Sbjct: 244 APTFWLNPEVKNFYEFTPDDVRLDNYETGSQIKNIPIAV 282 >UniRef50_C4Z7Z1 Thymidylate synthase n=19 Tax=Bacteria RepID=C4Z7Z1_EUBR3 Length = 282 Score = 265 bits (677), Expect = 1e-69, Method: Composition-based stats. Identities = 87/279 (31%), Positives = 135/279 (48%), Gaps = 18/279 (6%) Query: 2 KQYLELMQKVLDEGTQKN---------DRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHL 52 K ++ + Q +L+ GT D T T+ FG R++L FP +T ++ ++ Sbjct: 6 KVFVAMCQDILENGTSTEGELVRPHWEDGTSAYTIKKFGVVNRYDLSKEFPAITLRKTYI 65 Query: 53 RSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQI 112 +S ELLW Q +N +H+ +WDEWADE+G +G YG Q +DQ+ Sbjct: 66 KSATDELLWIWQKKSN--NIHDLKSHVWDEWADEDGSIGKAYGYQLGVKHQYKEGMMDQV 123 Query: 113 TTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGK------LSCQLYQR 166 V+ LK+ P SRRI+ + + +L +M L PC F V K L+ L QR Sbjct: 124 DRVIYDLKHTPFSRRILTNIYVHQDLHEMNLYPCAYSMTFNVTQKKGDDRLTLNGILNQR 183 Query: 167 SCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRP 226 S DV +N+ YA+L+HM+AQ CD+ VG+ V D H+Y H+ + R Sbjct: 184 SQDVLAANNWNVCQYAVLMHMLAQVCDMRVGELVHVIADAHIYDRHVPIVKELIERPQYD 243 Query: 227 LPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIK-APVAI 264 PK + + + + +D +I Y IK P+A+ Sbjct: 244 APKFWLNPDIKDFYQFTTDDIKITDYVTGEQIKDIPIAV 282 >UniRef50_A8H1B4 Thymidylate synthase n=132 Tax=root RepID=TYSY_SHEPA Length = 283 Score = 261 bits (667), Expect = 2e-68, Method: Composition-based stats. Identities = 95/283 (33%), Positives = 142/283 (50%), Gaps = 19/283 (6%) Query: 1 MKQYLELMQKVLDEGTQKND-RTGTGTLSIFGHQMRFNLQD-GFPLVTTKRCHLRSIIHE 58 MKQYL+L Q+++DEGT + RTG L++ + +++ FPL+TT++ ++ I E Sbjct: 1 MKQYLDLCQRLIDEGTWVENSRTGKRCLTVINADLVYHVDKNEFPLITTRKSFYKAAIAE 60 Query: 59 LLWFLQGDTNIAYLHENNVTIWDEWADEN------------GDLGPVYGKQWRAWPTPDG 106 LL +++G N A W+ A++N D+G VYG Q RAW PDG Sbjct: 61 LLGYIRGYDNAADFRAIGCNTWNANANDNQAWLDNPHRKGIDDMGRVYGVQGRAWSKPDG 120 Query: 107 RHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQR 166 IDQ+ +++ L D R I+S +N GE L PC F + L +QR Sbjct: 121 GCIDQLRKIVDDLSKGIDDRGEILSFYNPGEFHMGCLRPCMHTHNFSLVGDTLHLTSFQR 180 Query: 167 SCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHL-QLSREPR 225 SCDV LGL FN L+ +MAQ + G + H+Y + ++ QL REP Sbjct: 181 SCDVPLGLNFNQVQVFTLLALMAQITGHKPGTAFHKIVNAHIYEDQLELMQEVQLKREPF 240 Query: 226 PLPKLIIKRKPESIFDY----RFEDFEIEGYDPHPGIKAPVAI 264 PKL+I +S+ D +DFE+ GY+ H I P ++ Sbjct: 241 TSPKLVINPNIKSLEDLETWVSIDDFEVTGYEHHEAISYPFSV 283 >UniRef50_Q8RGP6 Thymidylate synthase n=10 Tax=Fusobacterium RepID=TYSY_FUSNN Length = 275 Score = 257 bits (658), Expect = 2e-67, Method: Composition-based stats. Identities = 87/273 (31%), Positives = 134/273 (49%), Gaps = 14/273 (5%) Query: 2 KQYLELMQKVLDEGTQKN--------DRTGTGTLSIFGHQMRFNLQD-GFPLVTTKRCHL 52 K Y +++ + ++G D T S G+Q R + D L+T++ Sbjct: 7 KIYKDIVDTIAEKGIWSEGNVRTKYADGTAAHYKSYIGYQFRLDNSDDEAHLITSRFAPS 66 Query: 53 RSIIHELLWFL-QGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQ 111 ++ I EL W N+ L+E WDEW ++G +G YG Q Q Sbjct: 67 KAPIRELYWIWILQSNNVDVLNELGCKFWDEWKMQDGTIGKAYGYQI---AQETFGQKSQ 123 Query: 112 ITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVF 171 + V+N+LK +P+SRRI+ W EL +MAL PC Q+ V KL ++ QRSCDV Sbjct: 124 LHYVINELKKNPNSRRIMTEIWIPNELSEMALTPCVHLTQWSVIGNKLYLEVRQRSCDVA 183 Query: 172 LGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLI 231 LGL N+ Y++L ++A +C LE + +W + H+Y H D+ Q++RE K+ Sbjct: 184 LGLVANVFQYSVLHKLVALECGLEPAEIIWNIHNMHIYDRHYDKLIEQVNRETFEPAKIK 243 Query: 232 IKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 I +SIFD++ +D EI Y + VAI Sbjct: 244 INN-FKSIFDFKPDDIEIIDYKYGEKVSYEVAI 275 >UniRef50_UPI0001925B1E PREDICTED: similar to thymidylate synthase, partial n=1 Tax=Hydra magnipapillata RepID=UPI0001925B1E Length = 197 Score = 255 bits (651), Expect = 1e-66, Method: Composition-based stats. Identities = 106/241 (43%), Positives = 144/241 (59%), Gaps = 44/241 (18%) Query: 24 TGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEW 83 TGTLSIFG QMRFNL++ FPL+TTKR + ++ ELLWF+ G T+ L + V IW Sbjct: 1 TGTLSIFGGQMRFNLRESFPLLTTKRVFWKGVVEELLWFISGSTDGNILAQKGVQIW--- 57 Query: 84 ADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMAL 143 + + R + N + MAL Sbjct: 58 --------------------------------------NSNGTREFLDKCN---IPLMAL 76 Query: 144 APCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTG 203 PCH+F QFYVA+G+LSCQ+YQRSCD+ LG+PFNIASY+LL +++A C+L+ GDF+ T Sbjct: 77 PPCHSFCQFYVANGELSCQMYQRSCDMGLGIPFNIASYSLLTYIIAHVCNLKPGDFIHTL 136 Query: 204 GDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263 GD H+Y+NH+ Q+ R PRP PKL IKRK E+I D++ +DFE+ GY+PH IK +A Sbjct: 137 GDAHVYNNHVSALKEQIGRSPRPFPKLNIKRKVENIDDFKSDDFELIGYNPHQKIKMAMA 196 Query: 264 I 264 + Sbjct: 197 V 197 >UniRef50_B9CJY5 Thymidylate synthase n=10 Tax=Bacteria RepID=B9CJY5_9ACTN Length = 282 Score = 254 bits (649), Expect = 2e-66, Method: Composition-based stats. Identities = 81/277 (29%), Positives = 133/277 (48%), Gaps = 18/277 (6%) Query: 4 YLELMQKVLDEGTQK---------NDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRS 54 + + +++ GT D T T+ FG R++L++ FP +T +R L+S Sbjct: 8 FTAMCSDIIEHGTTTVGEKVRPHWEDGTPAYTIKKFGVCNRYDLREEFPALTLRRTALKS 67 Query: 55 IIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITT 114 + E+LW Q +N +H+ N IWD WADE+G +G YG Q DQ+ Sbjct: 68 AMDEVLWIYQKKSN--NVHDLNSHIWDAWADESGSIGKAYGYQVGQKSHYAEGDFDQMDR 125 Query: 115 VLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADG------KLSCQLYQRSC 168 VL L+N+P SRRI+ + + +L +M L PC + V L+ L QRS Sbjct: 126 VLYDLQNNPFSRRIMTNLYTFADLSEMNLYPCAFNAIYNVTQNPGDAKPTLNLLLVQRSQ 185 Query: 169 DVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLP 228 D+ +N+ YA+L+ M+AQ ++ G+ V D H+Y H+D +SR P Sbjct: 186 DILAANNWNVCQYAILLMMVAQVSGMQAGELVHMISDAHIYDRHVDIVRELISRPIFAAP 245 Query: 229 KLIIKRKPESIFDYRFEDFEIEGYDPHPGIK-APVAI 264 + + + + +D +E Y+ P +K P+A+ Sbjct: 246 HVSLNPDVTDFYAFTTDDLIVENYEHGPQVKNIPIAV 282 >UniRef50_B7C7C1 Putative uncharacterized protein n=1 Tax=Eubacterium biforme DSM 3989 RepID=B7C7C1_9FIRM Length = 287 Score = 254 bits (649), Expect = 2e-66, Method: Composition-based stats. Identities = 92/279 (32%), Positives = 142/279 (50%), Gaps = 19/279 (6%) Query: 4 YLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFL 63 Y L + +L+ G Q ++RTG T+ I ++ FP++TTK+ +R + E+LW Sbjct: 8 YCGLCKDILENGVQVHNRTGIDTIKIPSAHFHLDVSKEFPILTTKQLFIRQAVTEMLWIY 67 Query: 64 Q-GDTNIAYLHENNVTIWDEW-ADENGD------------LGPVYGKQWRAWPTPDGRHI 109 Q ++ +L E NV IWD+W +E+GD P + + Sbjct: 68 QAQSNDVRWLQERNVHIWDKWEINEDGDWIDENTGNVLKHFDPSFAHTIGTAYGYIVKKY 127 Query: 110 DQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCD 169 D + +LN LKND + RR ++S W ELD L C ++ V DGKL+ ++QRSCD Sbjct: 128 DLMNKLLNSLKNDKEDRRRVISLWQDSELDTAVLPSCVWSSEWDVTDGKLNIWVHQRSCD 187 Query: 170 VFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPR---- 225 V LGLPFN+ YA+L+ M+AQ L+ G W+ D H+Y N +D QL+R Sbjct: 188 VPLGLPFNVTQYAVLLMMVAQVTGLKPGTIDWSIKDAHIYVNQVDGIKEQLNRYETKGSL 247 Query: 226 PLPKLIIKRKPESIFDYRF-EDFEIEGYDPHPGIKAPVA 263 P P+L + +D+ +D ++ GY+ I P+A Sbjct: 248 PAPELWLNPDVTDFYDFDPTKDVKLNGYEHMGKISFPLA 286 >UniRef50_D2RRK7 Thymidylate synthase n=9 Tax=cellular organisms RepID=D2RRK7_9EURY Length = 338 Score = 254 bits (649), Expect = 2e-66, Method: Composition-based stats. Identities = 116/340 (34%), Positives = 160/340 (47%), Gaps = 80/340 (23%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRC---HLRSIIH 57 M+QYLEL+ VL EGT K +RTG T+S F +LQDG+PL+TTK+ S++H Sbjct: 1 MRQYLELVDTVLSEGTYKPNRTGVDTISSFSEHYEVDLQDGYPLLTTKQMDGYRWNSMLH 60 Query: 58 ELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDG----------- 106 E+ W+L G+ +I L E IWD WAD+ G L YG+ WR +P P+ Sbjct: 61 EVCWYLSGEEHIRDLREET-KIWDAWADDEGRLDTAYGRFWRRFPIPEDDAQLEGESWPD 119 Query: 107 -------------RHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFY 153 R DQ+ V++ L + P+SRR++V+AW+ L PCH F F Sbjct: 120 ETHQWVTEEADGRRTFDQLQYVIDTLSDSPNSRRLVVNAWHPANAAVSTLPPCHYSFVFN 179 Query: 154 VADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYS--- 210 +L+C L QRS D LG+PFNIA+YALL ++AQQ + G F T DTH+Y Sbjct: 180 AQGDRLNCHLTQRSGDTALGIPFNIAAYALLTKVIAQQTGFKPGTFAHTVVDTHVYCGRG 239 Query: 211 -----------------------------------------------NHMDQTHLQLSRE 223 +H+ QLSRE Sbjct: 240 DRGEWYADNLETLQSRLNDVEDREDYLEVKSWLESAAPDEAEGDERLDHVPGLLEQLSRE 299 Query: 224 PRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263 P P L + SI + +ED E++ Y+ H GI+ VA Sbjct: 300 PLERPTLEVADV--SIDELAYEDVELKNYESHEGIEFAVA 337 >UniRef50_Q8WYK4 Thymidylate synthase n=7 Tax=Fungi/Metazoa group RepID=Q8WYK4_HUMAN Length = 230 Score = 254 bits (648), Expect = 3e-66, Method: Composition-based stats. Identities = 94/173 (54%), Positives = 123/173 (71%), Gaps = 1/173 (0%) Query: 93 VYGKQWR-AWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQ 151 V+G Q R + G+ +DQ+ V++ +K +PD RRII+ AWN +L MAL PCHA Q Sbjct: 58 VFGMQARYSLRDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALCQ 117 Query: 152 FYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSN 211 FYV + +LSCQLYQRS D+ LG+PFNIASYALL +M+A L+ GDF+ T GD H+Y N Sbjct: 118 FYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLN 177 Query: 212 HMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 H++ +QL REPRP PKL I RK E I D++ EDF+IEGY+PHP IK +A+ Sbjct: 178 HIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPHPTIKMEMAV 230 Score = 50.3 bits (119), Expect = 6e-05, Method: Composition-based stats. Identities = 22/38 (57%), Positives = 30/38 (78%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQD 40 QYL +Q +L G +K+DRTGTGTLS+FG Q R++L+D Sbjct: 32 QYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRD 69 >UniRef50_C6JM98 Thymidylate synthase n=6 Tax=Fusobacterium RepID=C6JM98_FUSVA Length = 276 Score = 250 bits (639), Expect = 3e-65, Method: Composition-based stats. Identities = 84/273 (30%), Positives = 131/273 (47%), Gaps = 14/273 (5%) Query: 2 KQYLELMQKVLDEGTQKN--------DRTGTGTLSIFGHQMRFNLQ-DGFPLVTTKRCHL 52 K Y E+++ + G D T S G+Q R + D L+TT+ Sbjct: 8 KIYKEIVEIIDKNGIWSEGNVRTKYADGTPAHYKSYIGYQFRLDNSTDEAHLITTRFAPN 67 Query: 53 RSIIHELLWFL-QGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQ 111 ++ I EL W ++ L++ WDEW +G +G YG Q + Q Sbjct: 68 KAPIRELYWIWIMQSNDVDELNKLKCKFWDEWKMNDGTIGKAYGYQI---AKQTFGYKSQ 124 Query: 112 ITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVF 171 + V+ +LK +P+SRRI+ W +LDKMAL PC Q+ V KL ++ QRSCDV Sbjct: 125 LDYVIGELKKNPNSRRIMTEIWVPEDLDKMALTPCVHLTQWSVIGNKLYLEVRQRSCDVA 184 Query: 172 LGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLI 231 LGL N+ Y++L ++A +C+LE + +W + H+Y HM Q+ R + Sbjct: 185 LGLVANVFQYSILHKLVAMECNLEPAEIIWNIHNVHIYDRHMPDLLEQIKRPSIDGATVK 244 Query: 232 IKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 I+ +SI+D++ +D +E Y I VAI Sbjct: 245 IEN-FKSIYDFKPDDVVVENYQYGEKISYEVAI 276 >UniRef50_C3IV33 Thymidylate synthase n=2 Tax=Bacillus thuringiensis RepID=C3IV33_BACTU Length = 306 Score = 248 bits (634), Expect = 1e-64, Method: Composition-based stats. Identities = 82/263 (31%), Positives = 129/263 (49%), Gaps = 22/263 (8%) Query: 19 NDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVT 78 D + T IFG R++L FP TT+ L++I E+ W + +N +++ Sbjct: 49 EDGSPIATKRIFGVVNRYDLSKEFPAPTTRPLPLKTIFDEVDWIYRKRSN--NVNDMRAK 106 Query: 79 IWDEWA-----------------DENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKN 121 IW++WA ++ G +G YG Q P + +Q+ VL +LK Sbjct: 107 IWNQWAFKKTRLRFSKTFPFVRLEKKGSIGEAYGYQV---AKPIFGYDNQMDYVLGELKR 163 Query: 122 DPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASY 181 DP +RR ++ WNV + +M L PC QF+ K + L QRS D FN+ Y Sbjct: 164 DPFTRRAVIEMWNVDDTGRMNLPPCAHHLQFWSDGKKTNLILKQRSQDFVTANAFNVCEY 223 Query: 182 ALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFD 241 A+L+HM+A+ EVG+ + GD H+Y+ H++ + REP P L I + + Sbjct: 224 AILLHMVARHIGQEVGELLHIIGDCHIYNKHLELAEELVKREPYAAPTLWINPEKTDFYS 283 Query: 242 YRFEDFEIEGYDPHPGIKAPVAI 264 + +DF +E YD HP +K VA+ Sbjct: 284 FTADDFRLENYDKHPQMKIEVAV 306 >UniRef50_Q934U8 Putative thymidylate synthase n=1 Tax=Salmonella enterica subsp. enterica serovar Typhi RepID=Q934U8_SALTI Length = 371 Score = 246 bits (628), Expect = 7e-64, Method: Composition-based stats. Identities = 115/349 (32%), Positives = 161/349 (46%), Gaps = 88/349 (25%) Query: 4 YLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDG-FPLVTTKRCHLRSIIHELLWF 62 Y ++++ VL+ G DRTGTGT S+ + L G PL++ K +L+ ++ EL W+ Sbjct: 23 YAKVVETVLNSGVHAGDRTGTGTKSVSYVPSYYMLTGGSVPLISGKAVNLKPLLVELEWY 82 Query: 63 LQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPD----------------- 105 L+G NI +L +N V IWD WADENGDLGPVYGKQWR W Sbjct: 83 LKGTGNIQFLKDNGVKIWDAWADENGDLGPVYGKQWRRWEDTRIVSHSEYLSKIDTFRER 142 Query: 106 -----------------GRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHA 148 R IDQ+ +++ L+ +P RRI+++AWNVGEL+ M L PCH Sbjct: 143 GYKVEGYLGVSEDRVVLSREIDQLQRIVHTLRTNPTDRRILLNAWNVGELEDMKLPPCHF 202 Query: 149 FFQFY-----------------VADGK--------------------------------- 158 F + + + Sbjct: 203 VFSLWSRKLDFETRLTMATDIGIQHNRHGHESIYTQMLCLLERDGGITENLLDELGIPKR 262 Query: 159 -LSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTH 217 L+ L QRS D F+G+PFNIA Y +L H +A+ G FV G D HLY NHM Sbjct: 263 ILNSCLVQRSVDTFVGMPFNIAGYGILTHFLAKITGHMAGAFVHFGFDVHLYDNHMGGVE 322 Query: 218 LQLSREPRP--LPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 + REP P +I + + D+++E ++ GY P P IK PVA+ Sbjct: 323 ELMKREPPKESDPVVIFPHEWAELDDFKWEGVQVCGYSPLPWIKVPVAV 371 >UniRef50_A8E2Q5 Putative thymidylate synthase n=1 Tax=Enterococcus phage phiEF24C RepID=A8E2Q5_BPPHE Length = 315 Score = 244 bits (622), Expect = 3e-63, Method: Composition-based stats. Identities = 91/311 (29%), Positives = 136/311 (43%), Gaps = 48/311 (15%) Query: 2 KQYLELMQKVLDEGTQK---------NDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHL 52 K Y +L+ ++ G + D T T I G G PL+ +K + Sbjct: 5 KIYKDLVMDIIKNGVTELPEGTRAVYADGTPATTKFIEGVNFTITPDMGAPLLRSKHVGI 64 Query: 53 RSIIHELLWFLQ-GDTNIAYLHENNVTIWDEWADENGDLGPVYGK--------------- 96 + + EL W Q +++L E VTIWDEW E+G +G YG Sbjct: 65 KWALTELQWIWQEMSNEVSWLKERGVTIWDEWEQEDGTIGKAYGYALFNKERFIPVYSGD 124 Query: 97 ---------------------QWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNV 135 W A ++Q+ V+ QLK+ P+SRRI+ + WNV Sbjct: 125 VELAKNRKAGSLIPKVVPKKGGWIAGTHQPYLKLNQVEAVIEQLKSTPNSRRIMTTLWNV 184 Query: 136 GELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLE 195 +L M+L PC + V +GKL+ + RS DV LGLPFNI Y L +MA LE Sbjct: 185 EDLYDMSLEPCVWTTHWTVVEGKLNLHVKARSSDVCLGLPFNIIQYHALQLVMANTVGLE 244 Query: 196 VGDFVWTGGDTHLYSNHMDQTHLQLSRE-PRPLPKLIIK-RKPESIFDYRFEDFEIEGYD 253 +G+ WT + H+Y H++ Q++ P +PKL++ +K + FD D + Y Sbjct: 245 LGNLYWTSDNAHIYERHLELVEKQVNEPIPEEVPKLVLPWKKGTNFFDSPLSDISVINYK 304 Query: 254 PHPGIKAPVAI 264 + VAI Sbjct: 305 HNGKFNYEVAI 315 >UniRef50_B9LR89 Thymidylate synthase n=4 Tax=Halobacteriaceae RepID=B9LR89_HALLT Length = 342 Score = 240 bits (614), Expect = 2e-62, Method: Composition-based stats. Identities = 119/344 (34%), Positives = 162/344 (47%), Gaps = 84/344 (24%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRC---HLRSIIH 57 M+QYL+L+ L GT K +RTG T++ F Q +L +GFPL+TTK+ S+IH Sbjct: 1 MQQYLDLVDDTLSTGTYKPNRTGVDTIATFSGQYTVDLSEGFPLLTTKKMDGYRWNSLIH 60 Query: 58 ELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDG----------- 106 E+LW+L G+ +I L E IWD WAD+ G L YG+ WR +P PDG Sbjct: 61 EVLWYLSGEEHIRDLREET-KIWDAWADDEGRLDTAYGRFWRRFPVPDGVDALPGETWPK 119 Query: 107 -----------------RHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAF 149 R DQI VL+ L +P SRR++V+AW+ L PCH Sbjct: 120 DAHRWVTVEEGPEGVERRTFDQIQYVLDTLDENPRSRRMVVNAWHPANAAVSTLPPCHYT 179 Query: 150 FQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLY 209 F V DG+L+ L QRS D+ LG+PFNIA+YALL + +AQ+ E+G+F T D H+Y Sbjct: 180 FVVNVQDGRLNLHLTQRSGDIALGVPFNIAAYALLANALAQRTGFEIGEFGHTVVDAHIY 239 Query: 210 S--------------------------------------------------NHMDQTHLQ 219 +H+ Q Sbjct: 240 CGRGDRGQWYANNLRYVQDRLATVESKADYLDVKSWVERTAPDEADGEERYDHVPGLLEQ 299 Query: 220 LSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVA 263 LSREPR P++ I KP + + +ED E+ YD GI VA Sbjct: 300 LSREPRERPRIEIADKP--LDELTYEDIEVVDYDSADGISFAVA 341 >UniRef50_C5H7L6 Thymidylate synthase n=3 Tax=unclassified Myoviridae RepID=C5H7L6_9CAUD Length = 299 Score = 235 bits (601), Expect = 9e-61, Method: Composition-based stats. Identities = 95/297 (31%), Positives = 149/297 (50%), Gaps = 33/297 (11%) Query: 1 MKQ----YLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSII 56 M Q Y ++ VL G + RTG + + RF+++ GFPL+T+K+ R +I Sbjct: 1 MSQADSSYKNILNHVLSVGELRTTRTGDVISAFAPPKFRFDMRTGFPLLTSKQVFTRQVI 60 Query: 57 HELLWFLQGDTNIAYLH-----ENNVTIWDEWADENGDL----------------GPVYG 95 E LWFL G+ + L EN+ W W+D+ G +YG Sbjct: 61 GEALWFLNGENKLGELRYRTWGENDGERWTIWSDDFKRWLSSNYSSEQDWLEDAGGRIYG 120 Query: 96 KQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGEL--DKMALAPCHAFFQFY 153 QWR + +G +DQ+ T++ ++K D R ++V+AWN ++ + MALAPCH FQ Y Sbjct: 121 VQWRNFEGHNGCVVDQLETLVTKMKGDITDRYMLVNAWNAADIAANSMALAPCHVLFQIY 180 Query: 154 VAD-GKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNH 212 + + G++ Q YQRS D FLGLPFNIASY ++ ++ + + GDT +Y NH Sbjct: 181 ITNEGEVDLQWYQRSVDTFLGLPFNIASYGFILEVLCKMTGYTPRYLIGVFGDTQIYQNH 240 Query: 213 MDQTHLQLSREPRPLPKLIIKRKPESIFDYRF---EDFE--IEGYDPHPGIKAPVAI 264 M Q + ++ E P I + ++ D + DF I Y I+AP+++ Sbjct: 241 MKQVYELMNNEEFHAPTFEIGVQLNTLSDLKHLTASDFIGGINNYQHAGKIEAPLSV 297 >UniRef50_A2SMX7 Thymidylate synthase n=1 Tax=Methylibium petroleiphilum PM1 RepID=A2SMX7_METPP Length = 316 Score = 225 bits (575), Expect = 9e-58, Method: Composition-based stats. Identities = 89/316 (28%), Positives = 137/316 (43%), Gaps = 56/316 (17%) Query: 1 MKQYLELMQKVLDEGTQK-NDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHEL 59 M+Q+ +++Q +LD G+++ N RTG L + G+ +RF++ DGFP +TTK+ + EL Sbjct: 1 MQQFHDMLQHILDHGSRQLNARTGEEVLFVPGYTLRFDMADGFPAITTKQLFFKMAKGEL 60 Query: 60 LWFLQGDTNIAYLHENNVTIWDEWA---------------DENGDLGPVYGKQWRAWPTP 104 F +G T+ A E T+W++ A D+ G G + WR W Sbjct: 61 FGFFRGFTSAAQFREIGCTVWNDNANKTKAWLANPYRQGEDDLGRFGYLQWTDWRDWREA 120 Query: 105 D---------------------------GRHIDQITTVLNQLKNDPDSRRIIVSAWNVGE 137 R I+Q+ T L+ + +P R II+S WN E Sbjct: 121 TTPAQRDEMLAQGYEVRAHDAERGVWILRRSINQLETSLHAVMTNPSDRGIILSGWNPAE 180 Query: 138 LDKMALAPCH--AFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLE 195 +D+ AL CH Q VA G L L+QRS D L +N+A A+ + +MA+ L+ Sbjct: 181 IDQGALRSCHVSYMLQVDVATGTLHLTLWQRSFDAPLA--YNVAIGAMYLEIMARLAGLK 238 Query: 196 VGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPES---------IFDYRFED 246 G F D H+Y+ H+ L+RE P P L + P Sbjct: 239 AGTFTHFISDAHIYAKHIPGVKEMLAREHFPQPTLDLGNIPTLTSAAEIPGIFATLDPNQ 298 Query: 247 FEIEGYDPHPGIKAPV 262 ++ Y HP I + Sbjct: 299 VKLVNYQHHPKIAFEM 314 >UniRef50_B8QTX3 Putative thymidylate synthase n=1 Tax=Erwinia phage phiEa21-4 RepID=B8QTX3_9CAUD Length = 311 Score = 223 bits (568), Expect = 5e-57, Method: Composition-based stats. Identities = 93/306 (30%), Positives = 138/306 (45%), Gaps = 44/306 (14%) Query: 2 KQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLW 61 +QY +L G ++ R+G F +R +++ FPL+T K + + ELLW Sbjct: 6 QQYKAFTANILSNGELRHSRSGNTISVPFPEDLRIDVRKEFPLLTCKSVPMSLVAGELLW 65 Query: 62 FLQGDTNIAYLHENN-------VTIWDEWADE---------------------------N 87 FL G T++ L TIW + Sbjct: 66 FLAGKTDLHSLRMYQFGSDEGQNTIWTADYERYSKAVKSLIRKVQTGESQEKTLRKIDAQ 125 Query: 88 GDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKM--ALAP 145 DLG +YG QWR + + D DQIT ++ +K +P SR IVSAWN + AL P Sbjct: 126 EDLGMIYGSQWREFESCD-TTCDQITRLIEGIKENPASRYHIVSAWNPVAVANNLGALPP 184 Query: 146 CHAFFQFYVADG-KLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGG 204 CH FFQ Y ++G + + YQRS D FLGLPFNIASYALL+ ++AQ + + G Sbjct: 185 CHMFFQVYASEGGYMDLRWYQRSVDTFLGLPFNIASYALLLRILAQMTGYTARYVIGSFG 244 Query: 205 DTHLYSNHMDQTHLQLSREPRPLPKLIIKR----KPESIFDYRFEDFE--IEGYDPHPGI 258 D H+Y NH+ + P L + +S+ F+ ++ Y + Sbjct: 245 DAHIYENHVPAVMQMMDNPEFDAPTLKLDNLDLSSLDSVLKLNGLVFKNALQDYQNAGVV 304 Query: 259 KAPVAI 264 KAP+++ Sbjct: 305 KAPLSV 310 >UniRef50_C7HUX5 Thymidylate synthase n=2 Tax=Anaerococcus RepID=C7HUX5_9FIRM Length = 287 Score = 220 bits (560), Expect = 5e-56, Method: Composition-based stats. Identities = 71/273 (26%), Positives = 130/273 (47%), Gaps = 21/273 (7%) Query: 2 KQYLELMQKVLDEGTQKN-----------DRTGTGTLSIFGHQMRFNLQDGFPLVTTKRC 50 ++Y+++ +++L++G + D T + +R+ + PL++ ++ Sbjct: 5 EKYIKIAKEILEKGYDEEELNKEVRPVWDDGESAYTKYLPQQVVRYE-KGELPLISLRKI 63 Query: 51 HLRSIIHELLWFLQ-GDTNIAYLHENN-VTIWDEWADENGDLGPVYGKQW--RAWPTPDG 106 +S I E+LW Q ++ L E V WD W +E+G+LG YG Q + G Sbjct: 64 AWKSAIKEILWIYQDRSNDVNLLKEKYKVNYWDSWKNEDGNLGTAYGYQINKKFKSPETG 123 Query: 107 RHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQR 166 + +QI +++Q+KN+P +RR+I++ +V ++ M L PC + V+ L+ L QR Sbjct: 124 QMTNQIERLIDQIKNNPLNRRLIMNLIDVDDMADMTLIPCAFLTMWTVSGEYLNLTLVQR 183 Query: 167 SCDVFLGL---PFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQL--S 221 S D N Y +L+ M+AQ + GDFV + H+Y H+ L Sbjct: 184 SGDFLAAAAPGGINAFQYYVLLRMVAQVTGYKAGDFVHFIQNYHIYKKHIPSVKKILEIK 243 Query: 222 REPRPLPKLIIKRKPESIFDYRFEDFEIEGYDP 254 + + P+L I + D+ +DF++ Y P Sbjct: 244 VDEKSKPRLEINPDIKEFKDFTIDDFKLIDYYP 276 >UniRef50_Q03LN3 Thymidylate synthase n=75 Tax=Firmicutes RepID=TYSY_STRTD Length = 286 Score = 207 bits (528), Expect = 2e-52, Method: Composition-based stats. Identities = 79/279 (28%), Positives = 124/279 (44%), Gaps = 18/279 (6%) Query: 4 YLELMQKVLDEGTQ-------KNDRTGTGTLSIFGHQMRFNLQDG-FPLVTTKRCHLRSI 55 + E + K+++EG D T + I G ++L G FP+ T + ++S Sbjct: 8 FKENITKIMEEGVWSEQARPKYKDGTTANSKYITGSFAEYDLSKGEFPITTLRPIAIKSA 67 Query: 56 IHELLWFLQGDTNIAYLHE--NNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQIT 113 I E+ W Q TN + E NV W++W E + + D I Sbjct: 68 IKEVFWIYQDQTNSLDVLEDKYNVHYWNDWEVEGVPANNGDKRSIGQRYGAVVKKHDIIN 127 Query: 114 TVLNQLKNDPDSRRIIVSAWNVGELDKMA-LAPCHAFFQFYVA----DGKLSCQLYQRSC 168 +L QL+ +P +RR ++S W+ ++ A L PC F V D L L QRS Sbjct: 128 RLLAQLEANPWNRRNVISLWDYEAFEETAGLQPCAFQTMFDVRRVGEDVYLDATLTQRSN 187 Query: 169 DVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRP-L 227 D+ + N Y L M+A+ +VG F + + H+Y N +Q L R+P Sbjct: 188 DMLVAHHINAMQYVALQMMIAKHFGWKVGKFFYFINNLHIYDNQFEQAEELLKRQPSDCQ 247 Query: 228 PKLIIK-RKPESIFDYRFEDFEIEGYDP-HPGIKAPVAI 264 P+L++ + FD + EDFE+ YDP P +K +AI Sbjct: 248 PRLVLNVPDETNFFDIKPEDFELVDYDPVKPQLKFDLAI 286 >UniRef50_B4Y380 MilA n=1 Tax=Streptomyces rimofaciens RepID=B4Y380_9ACTO Length = 334 Score = 205 bits (523), Expect = 1e-51, Method: Composition-based stats. Identities = 54/246 (21%), Positives = 89/246 (36%), Gaps = 12/246 (4%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRF-NLQDGFPLVTTKRCHLRSIIHELLW 61 YL ++ + +N G + G R + V +R ++ E LW Sbjct: 12 AYLSQLRDIYHSPEFRNAPRGQASRERIGAGFRLLDPVQRHISVPARRANVVFNFAEALW 71 Query: 62 FLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKN 121 +L G + ++ I AD G YG + P ++Q V+ L + Sbjct: 72 YLSGSDRLDFIQYYAPGIAAYSADGRTLRGTAYGPRIFRHPA---GGVNQWENVVKTLTD 128 Query: 122 DPDSRRIIVSAWNVGELD--KMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIA 179 DPDS+R ++ ++ EL C QF + DG L Y R+ D F G ++ Sbjct: 129 DPDSKRAVIQIFDPRELAVADNIDVACTLALQFLIRDGLLCGIGYMRANDAFRGAVSDVF 188 Query: 180 SYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSR-----EPRP-LPKLIIK 233 S+ L A+ L +G + G H+Y + L PRP P + Sbjct: 189 SFTFLQEFTARYLGLGIGTYHHVVGSVHIYDSDARWAERVLDAATPDGGPRPGFPAMPDG 248 Query: 234 RKPESI 239 + Sbjct: 249 DNWPHV 254 >UniRef50_B4TEI9 Thymidylate synthase n=2 Tax=Enterobacteriaceae RepID=B4TEI9_SALHS Length = 326 Score = 203 bits (516), Expect = 6e-51, Method: Composition-based stats. Identities = 55/247 (22%), Positives = 101/247 (40%), Gaps = 14/247 (5%) Query: 6 ELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQG 65 ++ Q +L +G ND T TL I G + T R L S + E LW+L Sbjct: 16 DVHQAILADGLS-NDPTKGSTLEILGAYLVLTDPRRRISRTESRGKLISCLGEFLWYLSA 74 Query: 66 DTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDS 125 ++ ++ + E A+ +G + YG + +Q+ V+N L+ + Sbjct: 75 QNDLEFIKHFIPR-YAESAESDGKIHGGYGPRLFNMRGL----YNQLKNVINLLQEKKPT 129 Query: 126 RRIIVSAWNVGEL-------DKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNI 178 RR ++ ++ +L + PC QF V +L + RS D F+GLP ++ Sbjct: 130 RRAVIQLFDASDLVPSKTEQREYVDIPCTISMQFIVRCEELHLFVCMRSNDAFMGLPHDV 189 Query: 179 ASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREP-RPLPKLIIKRKPE 237 ++ +L ++A+ E+G + HLY N +++ LP + + Sbjct: 190 FAFTMLQELVARLIGCELGHYHHFVSSLHLYKNDLEKVKALQKEGFMSTLPVMGSMPEMH 249 Query: 238 SIFDYRF 244 S+ D Sbjct: 250 SLDDILP 256 >UniRef50_Q13T72 Thymidylate synthase n=4 Tax=Burkholderiaceae RepID=Q13T72_BURXL Length = 354 Score = 202 bits (515), Expect = 8e-51, Method: Composition-based stats. Identities = 52/249 (20%), Positives = 108/249 (43%), Gaps = 16/249 (6%) Query: 2 KQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLW 61 K Y L++K G+ + T I G + + K+ L S + E LW Sbjct: 14 KVYGRLLRK---RGSDDINPTKGPATEINGALLVLKKPRARLSQSEKKNTLFSCLGEFLW 70 Query: 62 FLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKN 121 +L G + ++ ++ + +++D+ + YG + + DQ+ V+ L+ Sbjct: 71 YLAGSDKLDFIQ-YYISRYKDFSDDGKTVFGAYGPRLFGPTS----GTDQVQNVIQTLRA 125 Query: 122 DPDSRRIIVSAWNVGELDKM-----ALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPF 176 + SRR ++ ++ +L PC QF++ + +L+ + RS D F+GLP Sbjct: 126 NQHSRRAVIQLFHGDDLAANLVKRREDLPCTCTLQFFIRNYQLNAMVTMRSNDAFMGLPH 185 Query: 177 NIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRP---LPKLIIK 233 +I ++ +L ++A+ +EVG + G HLY+N+ + L+ + +P + Sbjct: 186 DIFAFTMLQELIARSLGVEVGQYKHAVGSLHLYANNTQAVNDYLAEGFQESVSMPPMPAG 245 Query: 234 RKPESIFDY 242 ++ Sbjct: 246 DPWPAVERL 254 >UniRef50_B2IB94 Thymidylate synthase n=2 Tax=Rhizobiales RepID=B2IB94_BEII9 Length = 342 Score = 200 bits (510), Expect = 3e-50, Method: Composition-based stats. Identities = 60/251 (23%), Positives = 112/251 (44%), Gaps = 17/251 (6%) Query: 1 MKQYLELMQKVLDE---GTQKNDRTGTG----TLSIFGHQMRFNLQDGFPLVTTKRCHLR 53 M+ E + +L +++ RT G T+ + G +R + R Sbjct: 1 MEIEKECLDAILYNLYWSIKEHGRTNAGSRGNTVELLGVALRILKPRARISRSENRGKPF 60 Query: 54 SIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQIT 113 S I ELLW+L G +A++ E V+ + + A G + YG + RA IDQ Sbjct: 61 SAIGELLWYLSGLDTLAFI-EPYVSAYRDDA-VAGVIQGAYGPRLRAMRD----GIDQFA 114 Query: 114 TVLNQLKNDPDSRRIIVSAWNVGEL-DKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFL 172 ++ L+ P+SRR ++ +N ++ + PC QF++ DG L + RS D + Sbjct: 115 SIETLLRQKPNSRRAVIQLFNAEDIATEHKEIPCTTTLQFHLRDGLLHMSVTMRSNDAYW 174 Query: 173 GLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPR---PLPK 229 GLP ++ + ++ MMA++ +E+G++ G H+Y H++ L + +P Sbjct: 175 GLPHDVFCFTMIQEMMARRLGVELGEYYHYVGSMHVYEKHLNHLDNYLVEGFQRTAEMPP 234 Query: 230 LIIKRKPESIF 240 + + + Sbjct: 235 MPAGDPFQLVD 245 >UniRef50_B0T6R4 Thymidylate synthase n=1 Tax=Caulobacter sp. K31 RepID=B0T6R4_CAUSK Length = 367 Score = 200 bits (510), Expect = 3e-50, Method: Composition-based stats. Identities = 50/242 (20%), Positives = 102/242 (42%), Gaps = 12/242 (4%) Query: 10 KVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNI 69 K+L + + T T+ G + + H+ S I E +W++ + Sbjct: 17 KLLLKSKMRVSATKGTTVEEHGVVLELTRPRARLSRAHMKGHVFSCIGEFIWYISCSNRL 76 Query: 70 AYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRII 129 + E ++ + ++A+++G + YG + G Q V L P +R+ + Sbjct: 77 EPV-EYYISRYKKFAEKDGTVWGAYGPRIF------GGDRSQYEVVKEMLSERPSTRKAV 129 Query: 130 VSAWNVGE-LDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMM 188 + ++ + L PC QF V DG L+ ++ RS DV++GLP +I ++ ++ ++ Sbjct: 130 IQLFDREDVLQDYNDIPCTCTMQFLVRDGMLNLVVHMRSNDVYMGLPHDIFAFTMIQEIL 189 Query: 189 AQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRP---LPKLIIKRKPESIFD-YRF 244 A ++G + G HLY + ++ L +P +P + + I + Sbjct: 190 AHDLGFKLGTYKHMVGSFHLYDHDREKVEQYLKEGFQPTREMPAMPSGNQWGHITALLKI 249 Query: 245 ED 246 ED Sbjct: 250 ED 251 >UniRef50_C0ELR2 Putative uncharacterized protein n=1 Tax=Neisseria flavescens NRL30031/H210 RepID=C0ELR2_NEIFL Length = 309 Score = 199 bits (505), Expect = 1e-49, Method: Composition-based stats. Identities = 75/285 (26%), Positives = 120/285 (42%), Gaps = 44/285 (15%) Query: 2 KQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLW 61 +QY++L++ +LD +N+RTGT +I Q D FP +T +R + +S + E+L Sbjct: 21 QQYVQLLKDLLDAPLVRNERTGTACHTIINPQSFTYTADDFPALTIRRSYWKSAVAEMLG 80 Query: 62 FLQGDTNIAYLHENNVTIWDEWADEN------------GDLGPVYGKQWRAWPTPDGRHI 109 +++G T+ E WD A++N D+G VYG ++ Sbjct: 81 YIRGYTSAKDFRELGTKTWDANANQNPAWLANPHRAGVDDMGLVYGAVGNSFTGLS---- 136 Query: 110 DQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCD 169 T ++ + D+R +I S WN DK L PC QF + +G L QRSCD Sbjct: 137 --FTDIMRAIHARQDNRGLIWSFWNPDVFDKGCLRPCMYSHQFSIVNGTLYLTSTQRSCD 194 Query: 170 VFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPK 229 V LGL FN+ L++++ L+ G + H+Y N +D ++ P Sbjct: 195 VPLGLTFNMIQCWFLLYLVCTLTGLKFGHARHNIVNAHIYENQVDAVREMIAN-----PL 249 Query: 230 LIIKRKPESIFDYR---------------------FEDFEIEGYD 253 L K + + DFE+ GYD Sbjct: 250 LPRSIKFQHVDRMTGRVRMGVEDVDSALLFLNSCDVNDFELLGYD 294 >UniRef50_Q6X183 Thymidylate synthase (Fragment) n=1 Tax=Enterobacteria phage TuIa RepID=Q6X183_9CAUD Length = 166 Score = 198 bits (504), Expect = 2e-49, Method: Composition-based stats. Identities = 78/166 (46%), Positives = 106/166 (63%), Gaps = 12/166 (7%) Query: 111 QITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDV 170 Q+ ++++K P+ RR IVSAWN E+D+MAL PCH F+QF V +G L Q YQRS DV Sbjct: 1 QLVKTIDRIKALPNDRRQIVSAWNPAEIDQMALPPCHMFYQFNVRNGHLDLQWYQRSVDV 60 Query: 171 FLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKL 230 FLGLPFNIASYA L H++A+ C+L GD V++GG+TH+YSNH++Q + REP+ L L Sbjct: 61 FLGLPFNIASYAALTHIVAKMCNLIPGDLVFSGGNTHIYSNHVEQCKEVIRREPKELCSL 120 Query: 231 II------KRKPESIF------DYRFEDFEIEGYDPHPGIKAPVAI 264 I + P I DF ++ Y+ HP IKA +A+ Sbjct: 121 EITWPSNFENWPTKIQMDWVTGTMTHTDFVLKNYESHPAIKAKMAV 166 >UniRef50_B2HI72 Thymidylate synthase, ThyA_1 n=1 Tax=Mycobacterium marinum M RepID=B2HI72_MYCMM Length = 316 Score = 198 bits (503), Expect = 2e-49, Method: Composition-based stats. Identities = 52/256 (20%), Positives = 102/256 (39%), Gaps = 18/256 (7%) Query: 6 ELMQK----VLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLW 61 +L+++ + ++G T T + G + T R R+ I +L W Sbjct: 12 DLLREAYTAIREQGQPVL-PTRAPTRELIGVSLELTEPRCRLSRTEARRLSRTGIAQLAW 70 Query: 62 FLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKN 121 +L G TN + + +G + YG + Q TVL LK Sbjct: 71 YLSGTTNPEMILHWVPN-HRNELEADGTIHGAYGPRMFGTGDNA-----QFCTVLELLKT 124 Query: 122 DPDSRRIIVSAWNVGELD---KMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNI 178 SRR ++ ++ +L + PC QF+V D +L + RS D ++GLP ++ Sbjct: 125 SSSSRRAVIQLFDATDLTGPGRYKDVPCTNTLQFFVRDSRLHLMVTMRSNDAYIGLPLDV 184 Query: 179 ASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNH----MDQTHLQLSREPRPLPKLIIKR 234 ++ +L +MA + + +G ++ + G H+Y + +D P+P + + Sbjct: 185 FAFTMLQELMAGELGIGIGRYIHSVGSLHIYEYNKEAIIDFLAEGWQSTDTPMPAMPAQS 244 Query: 235 KPESIFDYRFEDFEIE 250 + + + +I Sbjct: 245 LTRHVPQFLASELQIR 260 >UniRef50_Q7Y427 dTMP (Thymidylate) synthase n=3 Tax=unclassified T4-like viruses RepID=Q7Y427_9CAUD Length = 410 Score = 197 bits (502), Expect = 2e-49, Method: Composition-based stats. Identities = 78/158 (49%), Positives = 105/158 (66%), Gaps = 4/158 (2%) Query: 110 DQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCD 169 DQ+ V+ Q+KN+P RRII+ +WNV L CH F QFYV +GKLSC +QRS D Sbjct: 254 DQLQNVIEQIKNNPTDRRIIIDSWNVQGTHNAVLGVCHPFVQFYVNEGKLSCMWFQRSVD 313 Query: 170 VFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPK 229 FLGLPFN+ASYALL H++A+ CDLEVG+ +++GGDTH+Y NH DQ QLSR P P Sbjct: 314 SFLGLPFNVASYALLTHIIAKMCDLEVGELIFSGGDTHIYKNHFDQVMEQLSRVPFDKPT 373 Query: 230 LIIKRKPESIFDY---RFEDFEIEGYDPHPGIKAPVAI 264 + + + +S+ + +DF+I Y HP I A +A+ Sbjct: 374 IEL-PEFKSLDEVLTKTPKDFKIHNYQSHPAITAQMAV 410 Score = 107 bits (268), Expect = 4e-22, Method: Composition-based stats. Identities = 49/127 (38%), Positives = 67/127 (52%), Gaps = 18/127 (14%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL 60 MK+YL+L++ VLD G + DRTG GTLS FG +MR +L GFPL+TTK+ S+I ELL Sbjct: 1 MKEYLKLLRDVLDNGWPREDRTGVGTLSKFGAEMRIDLSKGFPLLTTKKMATASVIGELL 60 Query: 61 WFLQGDTNIAYLHENNVTIWDEWADE------------------NGDLGPVYGKQWRAWP 102 WF++G + L E +DE A + ++G +YG WR P Sbjct: 61 WFMEGSLDRRRLQEITRGKFDEEAFDIWRGNCLDMKEKNPLRFNGYNVGNMYGMAWRRKP 120 Query: 103 TPDGRHI 109 I Sbjct: 121 IHPHGEI 127 >UniRef50_Q03W75 Thymidylate synthase n=13 Tax=Bacteria RepID=Q03W75_LEUMM Length = 335 Score = 195 bits (495), Expect = 2e-48, Method: Composition-based stats. Identities = 50/246 (20%), Positives = 104/246 (42%), Gaps = 9/246 (3%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVT-TKRCHLRSIIHELLW 61 Y+ + ++ N+ G + G + + + T++ ++ E LW Sbjct: 10 AYIAELNEIYHHAEFFNEPRGFSSREKLGVHFKIENPVQRIVYSQTRKTNIIFNFAEALW 69 Query: 62 FLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKN 121 +L G+ +++Y+ N + D D G YGK+ + + ++Q V +L N Sbjct: 70 YLTGNNSLSYISYYNKRMPDYSMDGQTLTGTAYGKKLFHFGEQN---LNQWQNVKQELLN 126 Query: 122 DPDSRRIIVSAWNVGEL--DKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIA 179 D DS+R ++ ++ EL ++ C QF + + +L+ Y R+ D F G+ +I Sbjct: 127 DADSKRAVIQIFDAHELTINQNLDVSCTLGLQFLIRNNQLNMVAYMRANDAFRGIVSDIF 186 Query: 180 SYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSR---EPRPLPKLIIKRKP 236 S+ + MA++ +L+VG + + G H+Y L+ + PK+ Sbjct: 187 SFTFIQEFMARELNLKVGKYYHSVGTMHIYEPDNQWVTHVLNESNDQTFISPKMPQGNNW 246 Query: 237 ESIFDY 242 + + Sbjct: 247 AMVHEL 252 >UniRef50_A7TUR1 Putative thymidylate synthase n=3 Tax=Streptomyces RepID=A7TUR1_STRLI Length = 308 Score = 194 bits (494), Expect = 2e-48, Method: Composition-based stats. Identities = 60/254 (23%), Positives = 109/254 (42%), Gaps = 14/254 (5%) Query: 13 DEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLV--TTKRCHLRSIIHELLWFLQGDTNIA 70 G + + R G T + + + + + E +W L G + Sbjct: 13 KSGEKISPR-GMATHEVRDVHLLLTQPRARLFYAPPARIVNPAFAVAETVWHLSGS-DAP 70 Query: 71 YLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIV 130 ++ + N + ++AD+ LG YG + R W G +DQ+ V+ L+ D DSRR ++ Sbjct: 71 WIFDYNYRL-RQFADDGVLLG-AYGPRMRNW----GGKVDQLARVVEILQADSDSRRALI 124 Query: 131 SAWNVG-ELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMA 189 ++ + PC F+F++ G+L R DV++G+P+++ Y +L ++A Sbjct: 125 QLYDPAQDAAGHKDVPCTLGFRFHLRAGRLHMATMMRGQDVWIGMPYDVFFYTVLHELVA 184 Query: 190 QQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEI 249 D E+G+F G H+Y H++Q S + + R P + F + E Sbjct: 185 GWLDAELGEFHLHIGSLHIYDEHIEQADALTSLSASEI--MPDLRTPWTGFSGLLDQVEA 242 Query: 250 EGYDPHPGIKAPVA 263 HPG A +A Sbjct: 243 RDVTGHPGWDA-MA 255 >UniRef50_C8S1P3 Thymidylate synthase n=1 Tax=Rhodobacter sp. SW2 RepID=C8S1P3_9RHOB Length = 358 Score = 191 bits (486), Expect = 2e-47, Method: Composition-based stats. Identities = 47/266 (17%), Positives = 100/266 (37%), Gaps = 22/266 (8%) Query: 6 ELMQKVLDE-----GTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL 60 +LM+ V + G D + + +FG + + + S + EL Sbjct: 11 DLMRVVFKQLLTGRGNFVVDSSKGKSTEVFGALLELKNPRARLSRSFSKAKAFSPLGELF 70 Query: 61 WFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGR-HIDQITTVLNQL 119 W+L G + ++ + + + YG + R + V+ L Sbjct: 71 WYLSGSDRVEFIKHYIPN-YPKLIKDEVTANGAYGPRIFGKEALAKRDGASEWDRVIRTL 129 Query: 120 KNDPDSRRIIVSAWNVGE-LDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNI 178 + SR +V ++ + K PC QF + +G+L + RS D F GLP ++ Sbjct: 130 REREGSRNALVQIYDNSDAKPKNGDKPCTCTIQFAIRNGQLLMHTHMRSNDAFFGLPHDV 189 Query: 179 ASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNH--------------MDQTHLQLSREP 224 ++ +L + A++ L +G + + HLY + + + + + Sbjct: 190 FTFTMLQEIAARELGLGLGRYSHSVTSLHLYHDSAATKGRPANLSTSGAEAYYREGFHDY 249 Query: 225 RPLPKLIIKRKPESIFDYRFEDFEIE 250 P+P++ + +SI + + +I Sbjct: 250 SPMPEMPLGNPWKSIEQVKIAEHQIR 275 >UniRef50_P31654 Deoxyuridylate hydroxymethyltransferase n=2 Tax=Bacillus phage SPO1 RepID=DUHM_BPSP1 Length = 383 Score = 189 bits (480), Expect = 9e-47, Method: Composition-based stats. Identities = 58/271 (21%), Positives = 117/271 (43%), Gaps = 20/271 (7%) Query: 2 KQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFP-LVTTKRCHLRSIIHELL 60 + Y++++ V+ EG R G I + F + + + + E L Sbjct: 11 QLYMDILSTVIKEGDVLAPR-GKRIKEIRPVMIEFKNPIRRTTFLKGRNINPFFQVAESL 69 Query: 61 WFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHI-----DQITTV 115 W L G +++ +L + N + +++D+ YG++ R W D + DQ+ V Sbjct: 70 WILAGRSDVGFLLDYNKNM-GQFSDDGVFFNAPYGERLRFWNRSDANNFIYNPLDQLRDV 128 Query: 116 LNQLKNDPDSRRIIVSAWNV---GELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFL 172 ++K DPD+R+ + +N + PC+ F + +GKL +Y RS D+ Sbjct: 129 YEKIKADPDTRQAVAVIYNPLFDNINNDTKDRPCNLLLSFKLRNGKLDLSVYNRSNDLHW 188 Query: 173 G-LPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLI 231 G N+ ++ ++ MA +EVG + H+Y +D +++ + + + + Sbjct: 189 GTFGANLCQFSTILEAMATWLGVEVGSYYQITDSLHVY---LDDYGAKITEDIQKVYGVN 245 Query: 232 IKRKPESIFDYRFEDFEIEGYDPHPGIKAPV 262 ++ + EDFE E DP+P + + Sbjct: 246 LETDEAPV----VEDFE-ELLDPNPRMSYTM 271 >UniRef50_B5S769 Putative thymidylate synthase protein n=1 Tax=Ralstonia solanacearum RepID=B5S769_RALSO Length = 294 Score = 181 bits (460), Expect = 2e-44, Method: Composition-based stats. Identities = 56/226 (24%), Positives = 91/226 (40%), Gaps = 10/226 (4%) Query: 12 LDEGTQKNDRTGTGTLSIFGHQMRF-NLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIA 70 L G + R G TL + + + + + +R + I EL W L+G + + Sbjct: 5 LQNGQRTAPR-GVATLELLPVAFTINDPRRRYVSLPPRRWSIVYAIGELCWHLRGSSLVD 63 Query: 71 YLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIV 130 + + G YG + Q + V+NQL+ D DSRR ++ Sbjct: 64 EIAYYASRWRTIAGNATEVTGSNYGAKIFKGHR---GAPSQWSRVINQLRIDRDSRRAVL 120 Query: 131 SAWNVGEL--DKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMM 188 GE C QF + DGKL RS D LGLP+++ +++L M Sbjct: 121 YFSGTGEDTSSDSKDIACAVSLQFLIRDGKLDAIANMRSNDAMLGLPYDVFLFSMLQEMA 180 Query: 189 AQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLS---REPRPLPKLI 231 A ++VG + G HLY + + +S E RP+P++ Sbjct: 181 ANSLGVDVGKYNHVAGSLHLYESDLLLAKDIISSRASEIRPMPRME 226 >UniRef50_B5UXF4 Thymidylate synthase n=1 Tax=Bacillus cereus AH1134 RepID=B5UXF4_BACCE Length = 326 Score = 179 bits (454), Expect = 8e-44, Method: Composition-based stats. Identities = 50/248 (20%), Positives = 102/248 (41%), Gaps = 10/248 (4%) Query: 2 KQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQD--GFPLVTTKRCHLRSIIHEL 59 + YL L+ + + + D + +D P++ + + + E Sbjct: 11 EIYLNLLVEAITKKVNITDSRNGPVKDLGPAYFEITNEDLLRVPILQERALNPFFALTEF 70 Query: 60 LWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQL 119 W + G + L+ N + +D ++D+ L YG + R +DQ+ + L Sbjct: 71 SWIITGSNRLTPLN-NFINDFDRFSDDGFTLNGAYGHRLRELH-----GLDQLEKSIRIL 124 Query: 120 KNDPDSRRIIVSAWNVGEL-DKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNI 178 + + +RR++++ W++ +L PC+ + + L + RS D+FLG+P+N+ Sbjct: 125 QEEKSTRRVVLTMWHIDDLGSNSRDIPCNISIMLKIRNNLLDMTVINRSNDLFLGVPYNV 184 Query: 179 ASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPES 238 + LL +A++ +VG HLYS H ++ + K + K E Sbjct: 185 VVFYLLQCYIAKKIGCKVGVQRHFTDSLHLYSQHFEKVQSIIQNNNLERIKY-MYEKFEK 243 Query: 239 IFDYRFED 246 I + D Sbjct: 244 IDLSTYID 251 >UniRef50_C4SF99 Deoxyuridylate hydroxymethyltransferase n=1 Tax=Yersinia mollaretii ATCC 43969 RepID=C4SF99_YERMO Length = 335 Score = 175 bits (445), Expect = 9e-43, Method: Composition-based stats. Identities = 49/221 (22%), Positives = 97/221 (43%), Gaps = 9/221 (4%) Query: 22 TGTGTLSIFGHQMRF-NLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIW 80 G + + N ++ F ++ ++ ++ + + E +W L G ++ +L Sbjct: 4 RGQTQKEVLSTLTKIANPRERFLVIPERKNNVFAQLAETIWVLAGRGDLEFLQHYLPRSI 63 Query: 81 DEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNV-GELD 139 E++D+N YG + R W DQ++ V+++L+ DP+++R ++S ++ + Sbjct: 64 -EFSDDNKTWRAAYGPRLRNW----MGKTDQVSCVISRLQEDPNTKRAVMSLFDPMSDYS 118 Query: 140 KMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGL-PFNIASYALLVHMMAQQCDLEVGD 198 PC+ + QF D L + R+ D G N +++L ++A +VG Sbjct: 119 DTKDVPCNNWLQFIQRDNILYLHVTVRANDAIWGFSGINFFEWSVLHEIVATTLGYQVGT 178 Query: 199 FVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESI 239 W G H+YS H + + L R P +P SI Sbjct: 179 LSWYVGTFHIYSRHYNTSRDLL-RIKNPKSPYECGIEPTSI 218 >UniRef50_Q2T5Q0 Deoxyuridylate hydroxymethyltransferase , putative n=20 Tax=Burkholderia RepID=Q2T5Q0_BURTA Length = 329 Score = 174 bits (442), Expect = 2e-42, Method: Composition-based stats. Identities = 47/246 (19%), Positives = 97/246 (39%), Gaps = 13/246 (5%) Query: 4 YLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTK-RCHLRSIIHELLWF 62 YL + V ++ G I G+ R + + ++ E LW+ Sbjct: 11 YLATLSDVCGAYEFRSAPRGHAEREIIGYGARIDDPRARFCRRAARKQNVVFNYAEALWY 70 Query: 63 LQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQL-KN 121 L G ++ ++ ++ D G YG + R +DQI L+ L ++ Sbjct: 71 LSGRNDLEFIEHYAPSMARYSPDGKHLPGTGYGARLMH---YGARALDQIERALDILSRD 127 Query: 122 DPDSRRIIVSAWNVGEL--DKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIA 179 D +S+R+++ ++ E + C Q + +G+L + R+ D ++GL ++ Sbjct: 128 DAESKRVVLQIFSADEDLYRRNIDVSCTLGLQLLLREGRLHMVAFMRANDAYVGLLNDVF 187 Query: 180 SYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREP------RPLPKLIIK 233 S+ L +A + D E+G + G H+Y +++ + L P++ Sbjct: 188 SFTFLQEYVATRLDCEIGAYSHHVGSIHVYDDNLPRALALLDDSDAQIVTAAAPPRMPAG 247 Query: 234 RKPESI 239 P +I Sbjct: 248 TSPATI 253 >UniRef50_UPI00016AD9CB thymidylate synthase n=1 Tax=Burkholderia thailandensis MSMB43 RepID=UPI00016AD9CB Length = 193 Score = 173 bits (440), Expect = 4e-42, Method: Composition-based stats. Identities = 60/172 (34%), Positives = 86/172 (50%), Gaps = 13/172 (7%) Query: 106 GRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQF--YVADGKLSCQL 163 + IDQ+ L+ + DP SRRI+ WN LD++AL CH +QF V ++S L Sbjct: 22 HKAIDQLRDCLDTIVRDPSSRRILFHGWNPAVLDEIALPACHLLYQFLPNVERREISLCL 81 Query: 164 YQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSRE 223 Y RS DV LG PFN+A A L+ ++ + F + GD H+Y N +D QL RE Sbjct: 82 YIRSNDVGLGTPFNLAEGAALLTLVGRLTGYTPRWFTYFIGDAHIYENQLDMLKQQLERE 141 Query: 224 PRPLPKLIIKR-----------KPESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 P P+L I +P+ + DF + GY H + AP+A+ Sbjct: 142 PFESPRLEIAERVPDYAKTGEYEPQWLERIEPSDFALVGYRHHEPLTAPMAV 193 >UniRef50_B2ZYD3 Deoxyuridylate hydroxymethyltransferase n=1 Tax=Ralstonia phage RSL1 RepID=B2ZYD3_9CAUD Length = 414 Score = 172 bits (437), Expect = 9e-42, Method: Composition-based stats. Identities = 46/250 (18%), Positives = 87/250 (34%), Gaps = 28/250 (11%) Query: 8 MQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLV-TTKRCHLRSIIHELLWFLQGD 66 ++ + G + + R G + + + + E LW L G Sbjct: 59 LETICTVGLKTDSRNGPVIRFPTPVTSVYTHPRQRVSFDAVRDANPFLHLMEALWMLAGR 118 Query: 67 TNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSR 126 ++ + + E+ D+ L YG +WR DQ+ ++++LK +P SR Sbjct: 119 NDVEFASYYAKQML-EYTDDGSTLNGAYGFRWRQ-----HFGYDQLNAIIDELKKNPASR 172 Query: 127 RIIVSAWNVG------------------ELDKMALAPCHAFFQFYVADGKLSCQLYQRSC 168 R ++ W+ PC+ F GKL+ + RS Sbjct: 173 RCVLQMWDASREFYSREDSWAVRRESDLLNQGSKDLPCNTSVMFDAQLGKLNMTVTNRSN 232 Query: 169 DVFLG-LPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRP- 226 D+ G N+ +++L +A++C L +G + + H+Y D T + Sbjct: 233 DMIWGCYGANVVHFSMLHEYVAEKCGLPLGHYYQVSNNLHVYL-EFDITKRFIVDTTYGV 291 Query: 227 LPKLIIKRKP 236 P L Sbjct: 292 QPVLRKGPDV 301 >UniRef50_B3FJL1 Putative uncharacterized protein n=1 Tax=Pseudomonas phage 201phi2-1 RepID=B3FJL1_9CAUD Length = 457 Score = 169 bits (428), Expect = 9e-41, Method: Composition-based stats. Identities = 97/271 (35%), Positives = 125/271 (46%), Gaps = 80/271 (29%) Query: 74 ENNVTIWDEWADEN------GDLGPVYGKQWRA-----------WPTPDGRHIDQITTV- 115 E + I+ D+ GDLG VYGK WR W + R D + V Sbjct: 187 EYDQRIYRLLFDKEPMKLIGGDLGAVYGKTWRDIEDTRVIPKYDWVDYEARGFDFVVDVP 246 Query: 116 ---LN------------------QLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYV 154 + QL+ +PDSRRIIV AW +D+ AL PCH+FFQF+ Sbjct: 247 GTSIENDRCVVTRRIDQIQDIIDQLRTNPDSRRIIVCAWAPQLVDEQALPPCHSFFQFWT 306 Query: 155 A----------------------DGK-----------------LSCQLYQRSCDVFLGLP 175 DG +SC LYQRS D FLG P Sbjct: 307 RELTVEERIKLLRTTKPEIYNVIDGTTGYFEHIADINDIPKRAISCHLYQRSVDAFLGKP 366 Query: 176 FNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRK 235 FNI Y+LL H +A Q ++ +FVWTGGD H+YSNH +QT LQL+REP+ LP + + Sbjct: 367 FNITFYSLLTHWLANQLNMVADEFVWTGGDCHIYSNHQEQTDLQLTREPKALPTIRFTPE 426 Query: 236 P--ESIFDYRFEDFEIEGYDPHPGIKAPVAI 264 + I + R EDFEI Y+ HP I VA+ Sbjct: 427 AKGKDIREIRPEDFEILNYEFHPHIAGKVAV 457 Score = 96.5 bits (239), Expect = 8e-19, Method: Composition-based stats. Identities = 45/84 (53%), Positives = 59/84 (70%), Gaps = 1/84 (1%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDG-FPLVTTKRCHLRSIIHEL 59 M+QYL+ + + + G K DRTGTGT S G Q R++L+D P++TTK+ HL SIIHEL Sbjct: 1 MQQYLDSIIDIKENGVFKGDRTGTGTQSKLGQQERYSLRDNTLPVITTKKIHLPSIIHEL 60 Query: 60 LWFLQGDTNIAYLHENNVTIWDEW 83 +W L GDT + YL EN V IW+EW Sbjct: 61 IWMLSGDTRVDYLIENGVRIWNEW 84 >UniRef50_Q2FCV1 Thymidylate synthase n=2 Tax=Acinetobacter baumannii RepID=Q2FCV1_ACIBA Length = 222 Score = 168 bits (425), Expect = 2e-40, Method: Composition-based stats. Identities = 43/211 (20%), Positives = 82/211 (38%), Gaps = 18/211 (8%) Query: 11 VLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIA 70 +L+ G G + + ++ R L S I E W+L G ++ Sbjct: 19 ILENGDHITASKGEN-FEVRNAVLTLENPRSRLSISETRSKLISCIGEFFWYLNGSDSLE 77 Query: 71 YLHEN---NVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRR 127 ++ + DEN YG + +Q ++ LK+ P SRR Sbjct: 78 FIEYYISDYRKYIEYQIDENKPALGAYGPRIFGAQ-------NQFNKIIEVLKDKPTSRR 130 Query: 128 IIVSAWNVGEL--DKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLV 185 ++S ++ +L + PC QF++ + +L RS D +GL +I S+ L+ Sbjct: 131 AVISIYSKDDLLREDSRDIPCTCLLQFFIRNERLHLTATMRSNDAAIGLVHDIFSFTLIQ 190 Query: 186 H-----MMAQQCDLEVGDFVWTGGDTHLYSN 211 ++ +L++G++ G H+Y Sbjct: 191 ELLLAKLIRYIPNLQLGEYTHIVGSLHIYKK 221 >UniRef50_Q5DN81 Thymidylate synthase n=3 Tax=unclassified Siphoviridae RepID=Q5DN81_9CAUD Length = 350 Score = 167 bits (424), Expect = 3e-40, Method: Composition-based stats. Identities = 46/222 (20%), Positives = 95/222 (42%), Gaps = 14/222 (6%) Query: 8 MQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTT-KRCHLRSIIHELLWFLQGD 66 + + + G + R G ++ + L + + + + E LW L G Sbjct: 17 LAYLRESGLTRETRNGGAVVAPEPVTTVYEQPRERVLFSKLRDANPFFHLFEALWMLAGR 76 Query: 67 TNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSR 126 ++A++ + + ++D+ + YG +WR + DQ++ +++L+ P+ R Sbjct: 77 HDLAFVEKFAKNM-RSFSDDGETMWGAYGWRWRTFFD-----FDQLSWAVHRLRRLPNDR 130 Query: 127 RIIVSAWNVGELDKMAL-----APCHAFFQFYVAD-GKLSCQLYQRSCDVFLG-LPFNIA 179 R++V W G + A PC+ F + D G+L ++ RS D+ G N+ Sbjct: 131 RVVVQMWAAGLDQERADAGGKDVPCNIAIHFRINDRGQLDMTVWNRSNDIIWGAYGANVV 190 Query: 180 SYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLS 221 ++L +A +EVG + D H YS+ ++ +S Sbjct: 191 HMSILQEYVASAVGVEVGRYWQVSDDYHAYSDLFNKMLPLMS 232 >UniRef50_B8GIB9 Thymidylate synthase, methanogen type n=1 Tax=Methanosphaerula palustris E1-9c RepID=B8GIB9_METPE Length = 244 Score = 164 bits (416), Expect = 3e-39, Method: Composition-based stats. Identities = 43/227 (18%), Positives = 79/227 (34%), Gaps = 25/227 (11%) Query: 8 MQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDT 67 ++ VL++G G T+ ++ P+++T G Sbjct: 17 VKTVLEKGWVLGTEDGEATIECEELALQVENPTTEPMIST-----------------GSR 59 Query: 68 NIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGR-----HIDQITTVLNQLKND 122 E D +G Y + W +DQI ++ +L+ Sbjct: 60 FQRRFMEKYA--ADLLHGSDGIFEYDYHGRLFNWGDRLAADEAPVQVDQIAYIIRKLQEA 117 Query: 123 PDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYA 182 P +RR + WN +++ PC Q + DG L ++ RS D+ N+ + Sbjct: 118 PATRRALAITWNPVVDEQVKDCPCLQLVQCVIRDGALQMKVVFRSNDMLTASGANMFALV 177 Query: 183 LLVHMMAQQCDLEVGDFVWTGGDTHLY-SNHMDQTHLQLSREPRPLP 228 L M+A+ + +G + H+Y + MD +R R P Sbjct: 178 HLQLMIAEALGVRIGRYTHIALVPHVYFTRDMDDLKAFCNRGERFHP 224 >UniRef50_O26868 Putative thymidylate synthase n=2 Tax=Methanothermobacter RepID=TYSY_METTH Length = 222 Score = 163 bits (414), Expect = 4e-39, Method: Composition-based stats. Identities = 46/220 (20%), Positives = 82/220 (37%), Gaps = 14/220 (6%) Query: 4 YLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQ--DGFPLVTTKRCHLRSIIHELLW 61 + +L++K++ +G + D G+ T + + +R L +I + Sbjct: 14 WKKLVEKIMHDGREIRDERGSLTREVMNTVVTIKKPLGKSDDFYHIRRGSLLNIKVPEGY 73 Query: 62 FLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKN 121 F G+ + E + D G YG + RA +DQ+ + +LKN Sbjct: 74 FWSGE-KLEKYSEQFL-----SGDRKG-FVYTYGNRLRA-----HFGVDQLDEAIRRLKN 121 Query: 122 DPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASY 181 +SRR + W+ E PC F + DG+L RS D++ N Sbjct: 122 CTESRRATMVTWDPPEDTASDEVPCMILVDFKIRDGRLFTTALWRSHDIYGAWFPNAVGL 181 Query: 182 ALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLS 221 A L +A + +EVG H+Y + + + Sbjct: 182 AYLADHVAAEVGVEVGHITIHSISAHIYEVNFKEAEEVIK 221 >UniRef50_Q1ZMM6 Thymidylate synthase n=3 Tax=Gammaproteobacteria RepID=Q1ZMM6_PHOAS Length = 187 Score = 163 bits (413), Expect = 5e-39, Method: Composition-based stats. Identities = 63/186 (33%), Positives = 94/186 (50%), Gaps = 14/186 (7%) Query: 1 MKQYLELMQKVLDEGTQKND-RTGTGTLSIFGHQMRFNLQDG-FPLVTTKRCHLRSIIHE 58 MKQYL L Q+++D+G + RTG L++ + +++ + FPL+TT++ ++ I E Sbjct: 1 MKQYLALCQRIVDDGVWIENERTGKRCLTVINADLTYDVANNQFPLITTRKSFWKAAIAE 60 Query: 59 LLWFLQGDTNIAYLHENNVTIWDEWADEN------------GDLGPVYGKQWRAWPTPDG 106 LL +L+G N A W+ A++N D+G VYG Q R W DG Sbjct: 61 LLGYLRGYDNAAQFRAIGCNTWNANANDNQAWLNNPHRKGEDDMGRVYGVQGRRWQKSDG 120 Query: 107 RHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQR 166 IDQ+ +++ L D R I++ +N GE D L PC F + L YQR Sbjct: 121 TPIDQLKKIVDDLTKGIDDRGEILTFYNPGEFDMGCLRPCMHTHTFSLLGDTLYLTSYQR 180 Query: 167 SCDVFL 172 SCDV L Sbjct: 181 SCDVPL 186 >UniRef50_Q46E28 Putative thymidylate synthase n=5 Tax=Methanosarcinales RepID=TYSY_METBF Length = 217 Score = 162 bits (411), Expect = 9e-39, Method: Composition-based stats. Identities = 44/214 (20%), Positives = 71/214 (33%), Gaps = 23/214 (10%) Query: 8 MQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDT 67 + + + G D G+ + + I HE W Sbjct: 24 LNIIRNHGQVITDERGSQIREFMDLMIIIEDP-----------YTDRIPHETAW------ 66 Query: 68 NIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRR 127 N L E + + D YG++ R W +DQI V+ +L+ +P SRR Sbjct: 67 NEERLEEYAKQLI--SGENTQDFEYTYGQRLRNWH----GKVDQIDYVIEKLQQNPTSRR 120 Query: 128 IIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHM 187 I W K+ PC F + DGK+ RS D P N+ + L+ Sbjct: 121 AIAVTWIPPVDTKVNEVPCMMLDDFKIRDGKIHLTTLFRSHDFGGAYPANLYGLSKLLEY 180 Query: 188 MAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLS 221 +A + + G H+Y + D + Sbjct: 181 VADKVGTKPGTITTISISAHIYDHDWDMVENIVK 214 >UniRef50_Q8MVZ9 Bifunctional dihydrofolate reductase-thymidylate synthase (Fragment) n=1 Tax=Cercomonas longicauda RepID=Q8MVZ9_9EUKA Length = 314 Score = 162 bits (409), Expect = 1e-38, Method: Composition-based stats. Identities = 61/167 (36%), Positives = 94/167 (56%), Gaps = 22/167 (13%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDG-FPLVTTKRCHLRSIIHELLW 61 +Y++L++++ D+G + DRTG G +FG+ M+F+L++G PL+T ++ + ++ ELLW Sbjct: 148 EYIDLIRRIRDQGEIRTDRTGVGIKCVFGNMMKFSLENGQIPLLTIRKIFWKGVVEELLW 207 Query: 62 FLQGDTNIAYLHENNVTIWDEWADEN------------GDLGPVYGKQWRA--------W 101 L+G T+ L E V IW GDLGP+YG QWR Sbjct: 208 MLRGKTHSRDLEEKGVNIWRANGSREALDRLGMVDREVGDLGPIYGWQWRHSGAXYTTAH 267 Query: 102 PTPDGRHIDQITTVLNQLKNDPD-SRRIIVSAWNVGELDKMALAPCH 147 G +DQI V++QL+N P +RRI+ +WN +L +MAL PCH Sbjct: 268 TDYSGFGVDQIKDVISQLQNQPQKNRRILFCSWNPKDLKQMALPPCH 314 >UniRef50_Q21ZJ9 Thymidylate synthase n=1 Tax=Rhodoferax ferrireducens T118 RepID=Q21ZJ9_RHOFD Length = 347 Score = 160 bits (405), Expect = 5e-38, Method: Composition-based stats. Identities = 45/187 (24%), Positives = 74/187 (39%), Gaps = 13/187 (6%) Query: 37 NLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGK 96 + + + L + I E++W L G +L+ N + ++A G YG Sbjct: 48 DPRQRWVLSRRPAINPAFAIAEVIWILLGSDASNFLNFWNP-VLPKYAGSGGTYHGAYGA 106 Query: 97 QWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNV-GELDKMA------LAPCHAF 149 + R +DQI V L +P+SR+ ++ W+ +L PC+ Sbjct: 107 RLR-----THFGLDQIERVYQILSANPESRQAVLQIWDSREDLPLSDGASRDLDIPCNLV 161 Query: 150 FQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLY 209 V KL RS DVFLG P N+ + L ++A + +G F HLY Sbjct: 162 GMLKVRAQKLEWLQIMRSNDVFLGTPHNLVQFTSLQEIIAGWLGIGIGSFSLVTDSLHLY 221 Query: 210 SNHMDQT 216 + D+ Sbjct: 222 EHDYDRC 228 >UniRef50_B3QQU8 Thymidylate synthase n=1 Tax=Chlorobaculum parvum NCIB 8327 RepID=B3QQU8_CHLP8 Length = 343 Score = 158 bits (399), Expect = 2e-37, Method: Composition-based stats. Identities = 45/262 (17%), Positives = 90/262 (34%), Gaps = 32/262 (12%) Query: 11 VLDEGTQKNDRTGTGTLSIFGHQMR--FNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTN 68 ++ EG ++ R G + + M N V +R + E LW G + Sbjct: 20 LIKEGVKRKTR-GKLCIELPKPFMFKITNPTARLVTVPERRWNPILPFAESLWLATGKND 78 Query: 69 IAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRH-----------------IDQ 111 + ++ + ++D+ L YG + R + + + +DQ Sbjct: 79 LEFIGHYLKNM-KNFSDDGEFLRGGYGPRLRKYNGINDDYKIRNTYDIDIAKLNKSEVDQ 137 Query: 112 ITTVLNQLKNDPDSRRIIVSAWNV--------GELDKMALAPCHAFFQFYV--ADGKLSC 161 + + D +R+ I++ + G L PC F KL+ Sbjct: 138 FGFICKSFEKDKFTRQAIINIGDPPKDCFDKKGNLKITKDFPCTRLLHFQKQPKANKLNL 197 Query: 162 QLYQRSCDVFLGLPF-NIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQL 220 +Y RS D G NI ++ ++ +Q DLE+G++ + H Y D Sbjct: 198 TVYMRSNDFVWGASAVNIFNFTFMLEYFSQILDLEIGEYYHIANNFHYYEEFEDLVQSIS 257 Query: 221 SREPRPLPKLIIKRKPESIFDY 242 + K + ++ ++ Sbjct: 258 RTKTVEESKFEYSKSFHNLSEF 279 >UniRef50_UPI00016AEAE5 thymidylate synthase n=1 Tax=Burkholderia thailandensis MSMB43 RepID=UPI00016AEAE5 Length = 288 Score = 157 bits (397), Expect = 4e-37, Method: Composition-based stats. Identities = 47/221 (21%), Positives = 95/221 (42%), Gaps = 12/221 (5%) Query: 8 MQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTT-KRCHLRSIIHELLWFLQGD 66 + ++ EG + R G + + + + L+D V + + R + ELL + G Sbjct: 34 IHNIVKEGRKIKSRAGDA---MQAYGVNYILKDPRSRVHSLRNGAKRYLCRELLAYFSGS 90 Query: 67 TNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSR 126 N W D++G++ YG + P ++ +Q +++ LK++ DSR Sbjct: 91 LKAENGLANASKFWMTLTDKDGNVNSNYGY--YVFYEPVEKYGNQYNWIVSMLKSNQDSR 148 Query: 127 RIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVH 186 R I++ PC QF++ + L C+ RS DV GLP+++ ++ + Sbjct: 149 RAIININQNYHKSDTKDFPCTIGMQFFIRENHLFCETISRSTDVITGLPYDMGFFSFVHE 208 Query: 187 MMAQQC------DLEVGDFVWTGGDTHLYSNHMDQTHLQLS 221 ++ DL++G + T +Y N M++ ++ Sbjct: 209 LVHSDLVSQGYDDLQLGSTIMKTTFTQIYDNAMEKAKDAMN 249 >UniRef50_C5U4L9 Thymidylate synthase, methanogen type n=1 Tax=Methanocaldococcus infernus ME RepID=C5U4L9_9EURY Length = 212 Score = 156 bits (395), Expect = 6e-37, Method: Composition-based stats. Identities = 45/225 (20%), Positives = 91/225 (40%), Gaps = 30/225 (13%) Query: 2 KQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPL---VTTKRCHLRSIIHE 58 K Y L++++L++G++ G + ++ + + + S + Sbjct: 10 KAYEILVKEILEKGSEMITEDGQRCKELLNVFVKITNPKLKSISSKYPLGKNAIESYKKQ 69 Query: 59 LLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGR-HIDQITTVLN 117 LL +G N + Y ++ R +P+ D + DQ++ V+ Sbjct: 70 LL---EGSQN--------------------NFTYNYYERIREYPSYDRKLKNDQLSYVIE 106 Query: 118 QLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFN 177 +LKN+ SRR ++S W K+ PC F + + KL + RS D+ L N Sbjct: 107 KLKNNSTSRRAVISLWQPFIDQKVKDVPCLQHIGFQLREDKLIMSVLFRSNDILLAFHSN 166 Query: 178 IASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSR 222 L ++A+ ++E+ ++ + H+Y +D+ L R Sbjct: 167 ALGLISLGELVAKSLEVELKEYNHFIYNAHIY---IDRDKDYLRR 208 >UniRef50_C9DGK1 Deoxyuridylate hydroxymethyltransferase n=1 Tax=Deftia phage phiW-14 RepID=C9DGK1_9CAUD Length = 357 Score = 155 bits (391), Expect = 2e-36, Method: Composition-based stats. Identities = 44/230 (19%), Positives = 82/230 (35%), Gaps = 23/230 (10%) Query: 14 EGTQKNDRTGTGTLSIFGHQMRFNLQDGFPL-VTTKRCHLRSIIHELLWFLQGDTNIAYL 72 G K R G T + + L + ++ ++ ++ E W + G NI Sbjct: 26 TGQYKECRNGGST-FLRNVKFHITDPRNRNLTLNGRKSNIFQMVAETFWVMSGSGNIKEF 84 Query: 73 HENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSA 132 E + +++D+ + YG + +Q+ + ++ L D D+RR V Sbjct: 85 LEFFLPRAPQYSDDGINWHGAYGPRM--------YAHNQLQSAIDLLIKDKDTRRAYVMI 136 Query: 133 WNVGEL------------DKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPF-NIA 179 + PC+ + + KL ++ QRS D+ G N Sbjct: 137 ADPTLDSAPAIEAAYGVGHSPKDVPCNREIHINIIEDKLCMKVIQRSGDMLFGTGSINPF 196 Query: 180 SYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPK 229 + L ++++ +GD+ W D H Y DQ + L E P Sbjct: 197 EFTFLQELLSEATGYALGDYQWDVTDAHYYKAFEDQVNDVLRSEQTFWPN 246 >UniRef50_B2TJD1 Thymidylate synthase n=1 Tax=Clostridium botulinum B str. Eklund 17B RepID=B2TJD1_CLOBB Length = 333 Score = 153 bits (388), Expect = 4e-36, Method: Composition-based stats. Identities = 47/223 (21%), Positives = 89/223 (39%), Gaps = 15/223 (6%) Query: 21 RTGTGTLSIFGHQMRFN-LQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTI 79 RTG + + Q + + + EL+W + G+ ++ N ++ Sbjct: 31 RTG-DVFELLHTFISIEEPQQKWIYNRIPPISIGYALAELVWIINGEEKSDIINMWNPSL 89 Query: 80 WDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGEL- 138 +++A YGK+ R DQI L+N P+SR++++ ++ Sbjct: 90 -EKYAGRGDIYHGAYGKRIR-----SHFGFDQIEKAYEALQNTPESRQVVIQIYDTKVDF 143 Query: 139 ------DKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQC 192 + PC+ V +GKL RS DV LG+P+N + L ++A Sbjct: 144 PIEKGIPQDEDIPCNICSLLKVRNGKLEWSQIMRSNDVLLGMPYNFIQFTGLQEILAGWL 203 Query: 193 DLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRK 235 +L++G + HLY+ +++ + E R L + R Sbjct: 204 ELDLGSYNHYSDSLHLYARDINKIGIGQEVEIRNNDSLSLSRN 246 >UniRef50_Q2NEY9 ThyA n=1 Tax=Methanosphaera stadtmanae DSM 3091 RepID=Q2NEY9_METST Length = 209 Score = 152 bits (383), Expect = 1e-35, Method: Composition-based stats. Identities = 46/223 (20%), Positives = 80/223 (35%), Gaps = 30/223 (13%) Query: 2 KQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCH---LRSIIHE 58 + +L ++K++ EG + D G+ T + + + + H L + E Sbjct: 12 QAWLTCVKKIMQEGHEVTDERGSLTKELQNVILEITNPNDNTIPECSPWHDDRLETYKKE 71 Query: 59 LLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQ 118 LL D YG + R + IDQI T + + Sbjct: 72 LL----------------------DPDNEQGFVYTYGNRLRQY-----FKIDQIDTCIEK 104 Query: 119 LKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNI 178 L N P SRR I + + +K+ PC F + D +L + RS D N+ Sbjct: 105 LNNCPQSRRAIAITIDPIQDNKVDEIPCLQEIAFLIRDNQLYMTDFFRSNDCGGATFPNL 164 Query: 179 ASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLS 221 + + +A+ D E+ + V H+Y + D+ L Sbjct: 165 FGIREVGYYVAKNTDTELVNMVHHAMSLHIYEHDWDKCREILR 207 >UniRef50_Q7Y590 Putative uncharacterized protein RB69ORF048c n=3 Tax=unclassified T4-like viruses RepID=Q7Y590_BPR69 Length = 238 Score = 151 bits (382), Expect = 2e-35, Method: Composition-based stats. Identities = 42/230 (18%), Positives = 81/230 (35%), Gaps = 22/230 (9%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLW- 61 + + +++L+ D I + + F + + + E W Sbjct: 18 AFKAVNREILENPEFVTDSRIGRCNEIGSMTVVVDTPSSFKMTDPRINRISYEYAEDFWK 77 Query: 62 -FLQGDTNIAYLHENNVTIWDEWADENGD-----LGPVYGKQWRAWPTPDGRHIDQITTV 115 + G T+ + + + D YG + A Q+ + Sbjct: 78 FMISGGTDAEEAFKAYPNVAKFISKPKSDALPANFNTFYGPRIAA----------QLPAL 127 Query: 116 LNQLKNDPDSRRIIVSAWNVGE-----LDKMALAPCHAFFQFYVADGKLSCQLYQRSCDV 170 L +LK P+SRR++ + D+ PC +Y+ DGKL + RS + Sbjct: 128 LKELKEKPNSRRVVFQILESSDQALLDSDETLEYPCTDSVTYYIRDGKLYTHCHMRSQNC 187 Query: 171 FLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQL 220 + + + L+H +A +C +EVGD+ T H++ D L Sbjct: 188 AVVMQLDFYLQGKLLHYIANECGVEVGDYTHTMVSAHVFERDFDYVKGFL 237 >UniRef50_Q57931 Putative thymidylate synthase n=11 Tax=Methanococcales RepID=TYSY_METJA Length = 222 Score = 151 bits (382), Expect = 2e-35, Method: Composition-based stats. Identities = 40/223 (17%), Positives = 70/223 (31%), Gaps = 27/223 (12%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWF 62 + EL+ K+L +G T I + K+ + + E Sbjct: 12 AFNELIPKILKDGEVVETEFEERTKEIRNTIIEITNPK------LKKVPEKYPLGE---- 61 Query: 63 LQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKND 122 + E + + Y ++ +P I+QI ++ +L Sbjct: 62 -------KAVEEYTKNLLYGSKNV---FSYDYHQRLFEYP-YADEKINQIDYIIEKLNQQ 110 Query: 123 PDSRRIIVSAWNVGEL-----DKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFN 177 +SRR + WN D+ PC QF + +GKL + RS D L N Sbjct: 111 KNSRRAVAITWNPKIDIEVSRDERGSVPCLQLVQFLIRNGKLYQTVIFRSNDALLAFVSN 170 Query: 178 IASYALLVHMMAQQCDLEVGDFVWTGGDTHLY-SNHMDQTHLQ 219 L +A++ + G + H+Y D Sbjct: 171 AIGLITLGEYIAKKVGVGYGTYTHHAISMHIYVDRDFDYIKKY 213 >UniRef50_Q52PP0 Putative thymidylate synthase n=1 Tax=Xanthomonas phage Xp15 RepID=Q52PP0_9CAUD Length = 273 Score = 145 bits (366), Expect = 1e-33, Method: Composition-based stats. Identities = 47/237 (19%), Positives = 88/237 (37%), Gaps = 16/237 (6%) Query: 6 ELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQG 65 +LM + +G R G + Q+ F ++ + E+ W L G Sbjct: 13 DLMLRTFTQGFVSKPR-GMEIRELLNAQVTVQTFVPFQCWPDRKYDIGYFKKEMRWKL-G 70 Query: 66 DTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDS 125 + + + +W+ + +G YG+ W + V+ +L D DS Sbjct: 71 ASKFDDSIKQHAKMWESVQNPDGTFNSNYGQFWFGQQMG-------VMKVVMELIRDQDS 123 Query: 126 RRIIVSA-WNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALL 184 RR I+ + + C F++ L ++ RS D GL +I ++++L Sbjct: 124 RRAIIPMLTDDHLSPETVDTVCTEAVSFHIRHNTLYTSVHMRSSDQIFGLGTDIPTFSVL 183 Query: 185 VHMM-----AQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSR-EPRPLPKLIIKRK 235 H++ A L+VG T +H+Y H L E P +++I + Sbjct: 184 THLVHGLLQANYPSLQVGSMTITAASSHIYERHYRMVDKILDNLEDIPDSEIVILPQ 240 >UniRef50_C8XUG3 Putative thymidylate synthase n=1 Tax=Shigella phage phiSboM-AG3 RepID=C8XUG3_9CAUD Length = 348 Score = 143 bits (362), Expect = 5e-33, Method: Composition-based stats. Identities = 43/208 (20%), Positives = 87/208 (41%), Gaps = 24/208 (11%) Query: 25 GTLSIFGHQMRF-NLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEW 83 GT + G + +++D + V + + I E W L G +I +L + Sbjct: 37 GTRFLDGVTITVSDIRDRWLSVEGRNSSAIAAIGETFWVLSGRNDIKFLSRVLPR-AANF 95 Query: 84 ADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDK--- 140 +D+ YG + A Q+ +V+N+L+ +P++R+ ++ ++ Sbjct: 96 SDDGVTWRAAYGPRLYAHG--------QLDSVINRLRKNPNTRQAYLTIYDPALDSDAGL 147 Query: 141 ----------MALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPF-NIASYALLVHMMA 189 C+ F + DG+L+ + RS DV G+ N +++L ++A Sbjct: 148 AKFSESGEAKTKDMVCNLALLFAIVDGRLNLTVINRSQDVLWGMSSINFIEFSILQEVIA 207 Query: 190 QQCDLEVGDFVWTGGDTHLYSNHMDQTH 217 Q D++VG + + H Y+N + Q Sbjct: 208 QVLDVDVGQYKLFSNNLHYYNNEVSQKQ 235 >UniRef50_A3CSY2 Thymidylate synthase n=3 Tax=Methanomicrobiales RepID=A3CSY2_METMJ Length = 241 Score = 143 bits (360), Expect = 8e-33, Method: Composition-based stats. Identities = 35/227 (15%), Positives = 74/227 (32%), Gaps = 25/227 (11%) Query: 8 MQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDT 67 ++ VL++G + T+ + + P+ + + Sbjct: 17 VRTVLEKGWVLDTENDEATIECEELALEVESPESVPMASPASRFQQ-------------- 62 Query: 68 NIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTP-----DGRHIDQITTVLNQLKND 122 +L + + Y ++ W + H+DQI + +L+ Sbjct: 63 --RFLDVYADNL---LHGSDAKFEYDYHRRLFDWGEQLMVNGEDVHVDQIDYIARKLEQA 117 Query: 123 PDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYA 182 +SRR + WN + + PC Q + +GKL ++ RS D+ N+ + Sbjct: 118 ANSRRAVAVTWNPVVDENLDDCPCLQLVQCLLRNGKLQMKVVFRSNDILSAAGSNMYALV 177 Query: 183 LLVHMMAQQCDLEVGDFVWTGGDTHL-YSNHMDQTHLQLSREPRPLP 228 L M+A + + G + H+ Y ++ P Sbjct: 178 RLQKMIADRLGVPCGRYTHIALVPHIYYRRDLNDIEPFCKSGTEIRP 224 >UniRef50_A5UP11 Predicted thymidylate synthase, ThyA n=2 Tax=Methanobrevibacter smithii RepID=A5UP11_METS3 Length = 232 Score = 141 bits (357), Expect = 2e-32, Method: Composition-based stats. Identities = 39/227 (17%), Positives = 82/227 (36%), Gaps = 16/227 (7%) Query: 4 YLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTT-KRCHLRSIIHELLWF 62 YL+ ++K+L++G + + G+ + V + +++E Sbjct: 8 YLDFVKKILNQGKETYKDSNHHLKESLGNFYVIDDPLNLKFVAKYQHMTTDMMLNE---I 64 Query: 63 LQGDTNIA--YLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLK 120 G +I + + + + + + + D G VY R D +DQ + ++ Sbjct: 65 KSGKYDIEGCPIKSDALYEYVKSFENSDDQGFVYTYPNRILAHFD---VDQFEVMKKRML 121 Query: 121 NDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIAS 180 + S R + ++ PC F Q V + +L+ RS D+F N+ Sbjct: 122 HAIGSNRAVAVTYDPKLDQDREDIPCLQFLQCIVRNNELTIHCLFRSNDIFGAFYSNMFF 181 Query: 181 YALLVHMMAQQCDLEV-------GDFVWTGGDTHLYSNHMDQTHLQL 220 + M ++ + E+ G + H+YSN M + Sbjct: 182 ITYIGIKMKEELNKELLGEKVNFGGIHYHSTSGHIYSNDMKAAKKLI 228 >UniRef50_UPI0001C42129 thymidylate synthase ThyA n=1 Tax=Methanobrevibacter ruminantium M1 RepID=UPI0001C42129 Length = 236 Score = 141 bits (355), Expect = 3e-32, Method: Composition-based stats. Identities = 41/228 (17%), Positives = 79/228 (34%), Gaps = 16/228 (7%) Query: 4 YLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTT-KRCHLRSIIHELLWF 62 YLE + K+L EG + + G+ + + ++ E Sbjct: 8 YLEFVNKILKEGKETYKDSDHHLKEYLGNYYYIDDPLDLKFRAKYQHMTPELMLEE---I 64 Query: 63 LQGDTNIA--YLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLK 120 +G +I + + + + + + D G VY R +DQ + ++ Sbjct: 65 KKGRYDIDACPIKGDALYEYVKSFEIRDDQGFVYTYPNRILEH---FGVDQFEVMKERIL 121 Query: 121 NDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIAS 180 S R + ++ PC F Q V DG+L+ + RS D+F N+ Sbjct: 122 TATGSNRAVAVTYDPKLDHDREDIPCLQFVQMLVRDGELTIHVIFRSNDIFGAFYSNMFF 181 Query: 181 YALLVHMMAQQCDLEV-------GDFVWTGGDTHLYSNHMDQTHLQLS 221 + M ++ + E+ G + H+Y+N M +S Sbjct: 182 ICYMGIKMKEEVNKEIMGEKLNFGGIHYHSTSGHIYNNDMRAARKLIS 229 >UniRef50_P18029 Deoxycytidylate 5-hydroxymethyltransferase n=10 Tax=T4-like viruses RepID=DCHM_BPT2 Length = 246 Score = 141 bits (355), Expect = 3e-32, Method: Composition-based stats. Identities = 50/238 (21%), Positives = 85/238 (35%), Gaps = 22/238 (9%) Query: 12 LDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAY 71 L E D+TG T+ I G + + F +++ EL W+ + Sbjct: 19 LKEKDFVVDKTGVKTIEIIGASFVAD--EPFIFGALNDEYIQ---RELEWYKSKSLFVKD 73 Query: 72 LHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIV- 130 + IW + A G++ YG W W + D L +L +PDSRR I+ Sbjct: 74 IPGETPKIWQQVASSKGEINSNYG--WAIWSEDNYAQYDM---CLAELGQNPDSRRGIMI 128 Query: 131 ----SAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVH 186 S D M+ C Q+ + D K++ + RS DV G + A ++ Sbjct: 129 YTRPSMQFDYNKDGMSDFMCTNTVQYLIRDKKINAVVNMRSNDVVFGFRNDYAWQKYVLD 188 Query: 187 MMAQQCD-------LEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPE 237 + + + G +W G H+YS H + + K + + Sbjct: 189 KLVSDLNAGDSTRQYKAGSIIWNVGSLHVYSRHFYLVDHWWNTGETHIVKKDYNGEWK 246 >UniRef50_C9KVG6 Thymidylate synthase n=14 Tax=Bacteroidales RepID=C9KVG6_9BACE Length = 233 Score = 138 bits (348), Expect = 2e-31, Method: Composition-based stats. Identities = 52/221 (23%), Positives = 96/221 (43%), Gaps = 20/221 (9%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELL 60 M +Y + + K+L G + +R G + ++ D + + + + EL Sbjct: 22 MNKYYQTLDKILQTGKIQTNRKG-RIKYLLNERLMLTPADLLDIFESHGIARKKLKEELK 80 Query: 61 WFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLK 120 F+QG ++ E +T WD + P Y ++ + T +N+ K Sbjct: 81 LFMQGVRDVEKYKEAGITWWDYCGHTLVNSYPTYFEKL-----------PPLITRINREK 129 Query: 121 NDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIAS 180 + + + + V + APC + QF + +G+L YQRS D LGLP +I Sbjct: 130 RNSKNYVLFLGETGV----ESNQAPCLSLVQFQIDEGELVLSAYQRSSDANLGLPADIYH 185 Query: 181 YALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLS 221 +++MA+Q +L + G+ H+Y N++D+T LS Sbjct: 186 ----LYLMARQVELPLKSITLDLGNVHIYENNIDRTLELLS 222 >UniRef50_UPI0001C33797 thymidylate synthase n=3 Tax=Cyanobacteria RepID=UPI0001C33797 Length = 504 Score = 136 bits (342), Expect = 9e-31, Method: Composition-based stats. Identities = 44/232 (18%), Positives = 86/232 (37%), Gaps = 27/232 (11%) Query: 4 YLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFL 63 ++ ++ ++ G + G I + + F +R Sbjct: 203 WVRILHRIKTTGRVRPTEYGKWQELINIVAVVTDEPLDFYFPEPNYLPIR---------- 252 Query: 64 QGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDP 123 ++++ I D+ + G + YG++ R+W DQI V++ L +D Sbjct: 253 -----REFINDYISQILDDSSQREG-IKYTYGQRLRSW-----FKKDQIQQVIDLLVSDI 301 Query: 124 DSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYAL 183 +S R ++S W+V + D PC D +LS RS D+F P N Sbjct: 302 NSSRAVMSLWDVNDYDNNDSPPCLNHIWIRTIDDELSLTATFRSNDMFSAWPSNAMGLRA 361 Query: 184 LV-HMMAQQCD-----LEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPK 229 L H+M + + L++G V H+Y++ + + E + + Sbjct: 362 LQIHIMREIQNRINQKLKIGPLVTVSQSAHIYNDCWEYADKIVDAEYETICR 413 >UniRef50_B7KFY9 Thymidylate synthase n=11 Tax=Cyanobacteria RepID=B7KFY9_CYAP7 Length = 512 Score = 134 bits (338), Expect = 2e-30, Method: Composition-based stats. Identities = 42/229 (18%), Positives = 80/229 (34%), Gaps = 27/229 (11%) Query: 4 YLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFL 63 +++++ K+ GT +N G I + + F + Sbjct: 203 WIKILHKIRKTGTIRNTEYGEWQELIDIMAIVTDEPSDFYFPEPNYLSIE---------- 252 Query: 64 QGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDP 123 L + + + + G + YGK+ R+W DQI V+ +L D Sbjct: 253 -----RQNLQNYIEQMLSDLSSQEG-VEYTYGKRLRSWFKQ-----DQIEQVIKKLTLDI 301 Query: 124 DSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYAL 183 +S R ++S W+V + + PC V + +LS RS D+F P N Sbjct: 302 NSSRAVMSLWDVHDHEGNDNPPCLNHIWLRVVENELSLTATFRSNDMFSAWPANAMGLRA 361 Query: 184 LVHMMAQQCD------LEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRP 226 L + + L++G + H+YS+ + + + Sbjct: 362 LQQHILDNINQRASYSLKMGPLITVSQSAHIYSDCWEYADRLIDEQYAK 410 >UniRef50_A2E1C8 Putative uncharacterized protein n=1 Tax=Trichomonas vaginalis RepID=A2E1C8_TRIVA Length = 478 Score = 131 bits (330), Expect = 2e-29, Method: Composition-based stats. Identities = 43/259 (16%), Positives = 77/259 (29%), Gaps = 36/259 (13%) Query: 4 YLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQ-DGFPLVTTKRCHLRSIIHELLWF 62 + +++ K+++ G K R G + L+ + T + I E L Sbjct: 196 WKKVIHKIIEFGEFKK-RNSIGESYYELIDFTYVLEAENRKYETIETTGEVPITDEFL-- 252 Query: 63 LQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKND 122 E + G Y R + + +L+ D Sbjct: 253 --------------KHYITEIISDKVPPGLSYTYGNRIARH--------LDATVKKLQTD 290 Query: 123 PDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYA 182 P +R+ +S W ++ PC F + +L + RS D F L N+ Sbjct: 291 PVTRQAHISLWLDQDVSSPN-PPCLTDIDFNLQKNRLFMTCHFRSHDAFAALRSNMYGLV 349 Query: 183 LLVHM-MAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFD 241 L ++Q + G V +H+Y +D + P F Sbjct: 350 KLQEKVISQLPGVREGPLVLMANSSHIYERDIDTIKRSIVFGP------ECNADKRGYFT 403 Query: 242 YRFE--DFEIEGYDPHPGI 258 E + I YD + Sbjct: 404 VAVEEKNIVICHYDYENKL 422 >UniRef50_B1ZRC5 Thymidylate synthase-like protein n=1 Tax=Opitutus terrae PB90-1 RepID=B1ZRC5_OPITP Length = 295 Score = 127 bits (319), Expect = 5e-28, Method: Composition-based stats. Identities = 32/247 (12%), Positives = 85/247 (34%), Gaps = 21/247 (8%) Query: 32 HQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTN--IAYLHENNVTIWDE-WADENG 88 + P++ + E + + G + + +++ T W+ + Sbjct: 49 MNLTVLDPLAEPMIHKAFPGGIEELREYVMEVSGAKDHWVKNMNDPKDTRWEYTYHGRLA 108 Query: 89 DLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHA 148 G + G +++QI V+ +L P +R+ + W + PC Sbjct: 109 AYGTWQESRDGQPVRVGGFNVNQIEAVIAKLVKQPFTRQAQMITWMPNIDLECYDPPCLQ 168 Query: 149 FFQFYVADGK-----LSCQLYQRSCDVFLGLPFNIASYAL-----LVHMMAQQCD--LEV 196 + + + L+C + RS D + N+ + + + +A++ +++ Sbjct: 169 SLWYRLMEDDDGVSWLNCNVRFRSNDAWGASFMNMFGFVIFNRDVIAAEIARRTGKTIKL 228 Query: 197 GDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHP 256 G W H+Y + + +L ++ + +++ E + D Sbjct: 229 GRLNWQADSYHIYGKDIAEAKARL------FDRIPRGPLADRTYEFSDEGIQEMYNDAEA 282 Query: 257 GIKAPVA 263 ++A +A Sbjct: 283 AVRAKIA 289 >UniRef50_Q8MVZ8 Bifunctional dihydrofolate reductase-thymidylate synthase (Fragment) n=1 Tax=Chlamydaster sterni RepID=Q8MVZ8_9EUKA Length = 260 Score = 125 bits (314), Expect = 2e-27, Method: Composition-based stats. Identities = 54/115 (46%), Positives = 72/115 (62%), Gaps = 13/115 (11%) Query: 2 KQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDG-FPLVTTKRCHLRSIIHELL 60 KQYL+L+ +++ GTQ+ DRTGTGTLSIFG QMRF+ +D PL+TTK+ R + E+L Sbjct: 146 KQYLDLVDRIITSGTQRGDRTGTGTLSIFGTQMRFSPRDDTLPLLTTKKVFWRGVAEEML 205 Query: 61 WFLQGDTNIAYLHENNVTIWDEWAD------------ENGDLGPVYGKQWRAWPT 103 WF++G T+ L + IWD+ A E GDLGPVYG QWR + Sbjct: 206 WFMKGCTDARVLSAKKIHIWDDNASRKFLDENGLSHREEGDLGPVYGFQWRHFGA 260 >UniRef50_O28232 Thymidylate synthase, putative n=2 Tax=Archaeoglobaceae RepID=O28232_ARCFU Length = 480 Score = 124 bits (311), Expect = 3e-27, Method: Composition-based stats. Identities = 40/218 (18%), Positives = 72/218 (33%), Gaps = 14/218 (6%) Query: 8 MQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDT 67 ++ + G +K G L + H ++ E Sbjct: 257 LETIYTNGKKKRTEWGDIFEGQKESLFVHRLFLEVEKPEENKLHDKAPFTE-------KY 309 Query: 68 NIAYLHENNVTIWDEWADENGDL-----GPVYGKQWRAWPTPDGRHIDQITTVLNQLKND 122 I Y H+ + + + Y ++ R + D +DQ+ V+ +LK D Sbjct: 310 GIEYAHDYIMHAAKLDGEVRRSILKEGEEYTYAERAR-YCDRDDVKVDQLYKVIEKLKED 368 Query: 123 PDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYA 182 R V +L PC +QF +L Y RS D + + N+ ++A Sbjct: 369 SCRRDCYVGISRPWDL-LSDEPPCLRGYQFSKYGDELLGTFYMRSNDAYGAMHANMYAFA 427 Query: 183 LLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQL 220 LL +A+ + + D H+Y+ D L Sbjct: 428 LLTKYVAELTGFKSYRYNHFALDAHIYAEFFDAVREIL 465 Score = 58.4 bits (140), Expect = 3e-07, Method: Composition-based stats. Identities = 15/108 (13%), Positives = 34/108 (31%), Gaps = 2/108 (1%) Query: 112 ITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVF 171 + + +L+ P +RR + W + P ++ KL + RS + Sbjct: 122 VESAAEKLRKSPHTRRASIPLWYPKDHLCRN--PAAITEISFIFHEKLHLTAFLRSMECL 179 Query: 172 LGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQ 219 N + + ++ +E G H Y +++ Sbjct: 180 SYFEHNFDFLVEALETICRKTGMEEGSIGMLIAVPHFYERDVERALSY 227 >UniRef50_Q8MW00 Bifunctional dihydrofolate reductase-thymidylate synthase (Fragment) n=1 Tax=Amastigomonas debruynei RepID=Q8MW00_9EUKA Length = 259 Score = 123 bits (309), Expect = 6e-27, Method: Composition-based stats. Identities = 49/112 (43%), Positives = 67/112 (59%), Gaps = 12/112 (10%) Query: 4 YLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFL 63 YL+L+++VL +G +++DRTG GT S+FG ++ F+L DGFPL+TTKR R + ELLWF+ Sbjct: 148 YLDLIRRVLADGFERDDRTGVGTFSLFGEKLEFDLGDGFPLLTTKRVFWRGVAEELLWFV 207 Query: 64 QGDTNIAYLHENNVTIWDEWADEN------------GDLGPVYGKQWRAWPT 103 G TN L + IWD + GDLGPVYG QW + Sbjct: 208 SGSTNANELAAKGIRIWDGNSSREYLDSIGLTEREVGDLGPVYGFQWSHFGA 259 >UniRef50_Q8MVZ6 Bifunctional dihydrofolate reductase-thymidylate synthase (Fragment) n=1 Tax=Diplonema ambulator RepID=Q8MVZ6_9EUGL Length = 255 Score = 123 bits (309), Expect = 6e-27, Method: Composition-based stats. Identities = 48/115 (41%), Positives = 64/115 (55%), Gaps = 13/115 (11%) Query: 2 KQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGF-PLVTTKRCHLRSIIHELL 60 +QYL+L+ ++ G K DRTG GT+S FG QMRF+L+DG PL+TTKR + + EL Sbjct: 141 QQYLDLVDDIIKNGFTKGDRTGVGTISKFGAQMRFSLRDGVIPLLTTKRVFWKGVAEELF 200 Query: 61 WFLQGDTNIAYLHENNVTIWDEWADE------------NGDLGPVYGKQWRAWPT 103 WF++G TN L + V IWD DLGP+YG QW + Sbjct: 201 WFIKGCTNGKDLKDKGVHIWDGNGTRAFLDSRGLPDRAEDDLGPIYGLQWSHFGA 255 >UniRef50_A1RYR8 Thymidylate synthase-like protein n=1 Tax=Thermofilum pendens Hrk 5 RepID=A1RYR8_THEPD Length = 460 Score = 123 bits (308), Expect = 7e-27, Method: Composition-based stats. Identities = 38/232 (16%), Positives = 74/232 (31%), Gaps = 31/232 (13%) Query: 2 KQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLW 61 + +++L+ V+ G K G + G + + +R + R E Sbjct: 171 RAWVKLVDAVMTWGFVKGSEYGERQRQLLGAVVVLDASQPLD----ERVY-RYFPRE--- 222 Query: 62 FLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKN 121 +I + E G + YG + R DQ+ ++ +L + Sbjct: 223 ---------DFERQAKSILE---GEEGAV-YSYGDRLRRHREAG----DQVRRIVERLAS 265 Query: 122 DPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASY 181 PD+RR I W+ PC Q ++ + + RS D + P N Sbjct: 266 SPDTRRAIALTWDFATDTNSQDPPCLVAVQGDLSGDTYNQVAFFRSHDAYAAWPLNAYGL 325 Query: 182 ALLVHMMAQQCD------LEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPL 227 L+ +A + ++ G V H+Y + + + Sbjct: 326 LALMRRVAGELSERTGRAVKPGWLVVYSSSLHVYEHDWGRALRLVQENAAEA 377 >UniRef50_Q8TVL9 Putative thymidylate synthase n=1 Tax=Methanopyrus kandleri RepID=TYSY_METKA Length = 209 Score = 123 bits (308), Expect = 9e-27, Method: Composition-based stats. Identities = 32/149 (21%), Positives = 57/149 (38%), Gaps = 8/149 (5%) Query: 71 YLHENNVTIWDEWADENGDLG--PVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRI 128 L E++V +++ + G YG + R + +DQ+T ++ +L ++RR Sbjct: 65 PLDEHSVRAYEDQLLDPELRGFEYTYGHRLRRY-----FGLDQVTKIVERLSESNNTRRA 119 Query: 129 IVSAWNVGELDKMALAPCHAFFQFYVADGK-LSCQLYQRSCDVFLGLPFNIASYALLVHM 187 I W+ PC Q G L + RS DV L N+ + L Sbjct: 120 IAVTWDPRRDLDEEEVPCLTALQLQSDGGSGLELHAFYRSWDVGKALVANMIALRRLQEH 179 Query: 188 MAQQCDLEVGDFVWTGGDTHLYSNHMDQT 216 +A++ LE + H+Y + Sbjct: 180 VAERAGLEPTTLTVYAANAHVYEEDLPDL 208 >UniRef50_Q8MVZ5 Bifunctional dihydrofolate reductase-thymidylate synthase (Fragment) n=1 Tax=Tetrahymena sp. RepID=Q8MVZ5_9HYMN Length = 311 Score = 116 bits (291), Expect = 8e-25, Method: Composition-based stats. Identities = 57/114 (50%), Positives = 69/114 (60%), Gaps = 13/114 (11%) Query: 3 QYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDG-FPLVTTKRCHLRSIIHELLW 61 QYL+L+Q+V+ G + DRTGTGTLSIFG MRF+L G FPL+TTK+ LR I EL W Sbjct: 198 QYLDLVQRVVSTGVSRGDRTGTGTLSIFGAMMRFDLSSGAFPLLTTKKTFLRGIAEELFW 257 Query: 62 FLQGDTNIAYLHENNVTIWDEWADE------------NGDLGPVYGKQWRAWPT 103 FL+GDT+ L +V IWD A GDLGPVYG QW + Sbjct: 258 FLKGDTSQTRLAAKDVHIWDANATRAFLDARGLPDRPEGDLGPVYGCQWSHFGA 311 >UniRef50_Q2FKU7 Thymidylate synthase-like n=1 Tax=Methanospirillum hungatei JF-1 RepID=Q2FKU7_METHJ Length = 285 Score = 114 bits (286), Expect = 3e-24, Method: Composition-based stats. Identities = 49/235 (20%), Positives = 83/235 (35%), Gaps = 45/235 (19%) Query: 2 KQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLW 61 +QY + + T + D GT + +G+++R + +V+ ++ I L Sbjct: 69 EQYQASLYTI----TPRRD-DGTDAVYTYGNRLRDYPKAEVGIVSKHGGAVKKAIDALF- 122 Query: 62 FLQGDTNIAYLHENNVT--IWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQI-TTVLNQ 118 + Y+ + IW +G G IDQI +++N+ Sbjct: 123 -----RKLGYVPADACGELIWK----GDGRYG----------------GIDQIQESIINR 157 Query: 119 LKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYV-ADGKLSCQLYQRSCDVFLGLPFN 177 L +P+SRR I W + PC Q + + L+ RS D+ N Sbjct: 158 LIQNPESRRAISITWFPVQDITADEPPCLQLVQCVIDKNNHLNLICVFRSNDMLSAWGQN 217 Query: 178 IASYALLVHMMAQQCDLE---------VGDFVWTGGDTHLYSNHMDQTHLQLSRE 223 A L + +Q +L+ G H+Y H DQ L L E Sbjct: 218 AYGLAHLQKFICEQINLKRKNAEEKVSQGWLETISISAHMYF-HRDQLELNLFLE 271 >UniRef50_D2BHQ5 Thymidylate synthase n=5 Tax=Dehalococcoides RepID=D2BHQ5_DEHSV Length = 217 Score = 111 bits (278), Expect = 2e-23, Method: Composition-based stats. Identities = 30/117 (25%), Positives = 47/117 (40%), Gaps = 2/117 (1%) Query: 102 PTPDGRHIDQITTVLNQLKNDP-DSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLS 160 T QI V+ K ++ + ++ N LD PC V GKL Sbjct: 94 YTYGQYLEAQIAKVIKMYKETGFNTNQAFMTVGNPETLDL-EDPPCLRSIDTRVRYGKLH 152 Query: 161 CQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTH 217 +Y RS D++ G P N+A+ +L MA + +E G+ + H+Y D Sbjct: 153 FIIYFRSWDLWAGFPSNLAAIQMLKEYMAAEIGVEDGEIIAMSKGMHIYDYAWDIAK 209 >UniRef50_A9A0S4 Thymidylate synthase-like protein n=2 Tax=Desulfobacteraceae RepID=A9A0S4_DESOH Length = 263 Score = 108 bits (271), Expect = 2e-22, Method: Composition-based stats. Identities = 34/140 (24%), Positives = 55/140 (39%), Gaps = 4/140 (2%) Query: 79 IWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKN-DPDSRRIIVSAWNVGE 137 W E A E D GK + +I+QI V++ K + ++++ + Sbjct: 121 WWHENASEIVDRREPDGKI--VFEEDGRLYINQIEWVIDTYKRFGARNNQMVLQVAEPSD 178 Query: 138 LDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVG 197 L + PC + D +L +Y RS D++ GLP N+A L MA + + G Sbjct: 179 LALL-DPPCLRSIDTRIQDDQLIFFVYFRSWDLWGGLPANLAGIQNLKEYMAGEIGVADG 237 Query: 198 DFVWTGGDTHLYSNHMDQTH 217 + HLY D Sbjct: 238 PMIVESKGLHLYGYAEDLAK 257 >UniRef50_B8KML0 Putative thymidylate synthase n=1 Tax=gamma proteobacterium NOR5-3 RepID=B8KML0_9GAMM Length = 191 Score = 108 bits (270), Expect = 2e-22, Method: Composition-based stats. Identities = 30/132 (22%), Positives = 56/132 (42%), Gaps = 7/132 (5%) Query: 93 VYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQF 152 YG+ D IDQ ++ +L+N +++ +S G L++ L PC Sbjct: 48 TYGQLI-----YDMNGIDQFDWMVGRLRNKSETKSAAISLLVPG-LNQANL-PCLCVVDS 100 Query: 153 YVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNH 212 + +GKL+ Q + RS +VF N+ + A L +A ++G H+Y Sbjct: 101 KIRNGKLNLQFFFRSQNVFGRQYANLVAIARLQEKLAASVGCDIGILKGYIASAHIYEYD 160 Query: 213 MDQTHLQLSREP 224 +++ + P Sbjct: 161 LEEARSLVEGRP 172 >UniRef50_C0GRD7 Thymidylate synthase-like protein n=1 Tax=Desulfonatronospira thiodismutans ASO3-1 RepID=C0GRD7_9DELT Length = 224 Score = 105 bits (262), Expect = 2e-21, Method: Composition-based stats. Identities = 26/126 (20%), Positives = 48/126 (38%), Gaps = 2/126 (1%) Query: 102 PTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSC 161 T R Q+ + + + + I+ + + PC + DG+L Sbjct: 100 YTYGERIYQQVLYWIGKFNQTWATNQAILQVGRPED-HLLNDPPCLRHIDMRIRDGRLIF 158 Query: 162 QLYQRSCDVFLGLPFNIASYALLVHMMAQQC-DLEVGDFVWTGGDTHLYSNHMDQTHLQL 220 Y RS D++ G P N+A A+L MA + G + + H+Y + ++ Sbjct: 159 YPYFRSWDLWGGFPANLAGIAVLQKYMADSIEGVSPGPILASSKGLHIYGYAEELARIRT 218 Query: 221 SREPRP 226 R+ P Sbjct: 219 CRKDAP 224 >UniRef50_D2B6A6 Putative uncharacterized protein n=1 Tax=Streptosporangium roseum DSM 43021 RepID=D2B6A6_STRRD Length = 238 Score = 102 bits (255), Expect = 1e-20, Method: Composition-based stats. Identities = 27/138 (19%), Positives = 44/138 (31%), Gaps = 8/138 (5%) Query: 89 DLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHA 148 YG + R +DQ+ V + L+ P ++ +S GE PC Sbjct: 79 PFKYSYGGRLRRL-----LGVDQLHWVADVLRAKPYTKSGWISLTVPGESPDA--VPCLT 131 Query: 149 FFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHL 208 F + DG+L RS +VF + ++ +A + G H+ Sbjct: 132 SLAFRLRDGRLVMTAAFRSQNVFTSYLNYVPLRSIQNE-VAGDLGVGCGSMRVFVDVPHI 190 Query: 209 YSNHMDQTHLQLSREPRP 226 Y L R Sbjct: 191 YVADAAAVGEILRLSERD 208 >UniRef50_A5KRW4 Thymidylate synthase-like protein n=1 Tax=candidate division TM7 genomosp. GTL1 RepID=A5KRW4_9BACT Length = 208 Score = 100 bits (250), Expect = 4e-20, Method: Composition-based stats. Identities = 32/151 (21%), Positives = 58/151 (38%), Gaps = 8/151 (5%) Query: 69 IAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRR- 127 L N I+ ++ RA+ P+ QI ++++L DP S + Sbjct: 58 QEDLDIINRYIYTGENEDKVIHDWTKLYYHRAFDEPN----SQIEFLISKL--DPQSPKG 111 Query: 128 -IIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVH 186 +S W+ ++PC + GKL ++ S DV+ L NI + L H Sbjct: 112 EAQISMWDKNIDQDQKVSPCTQIIWARIKHGKLELHVHAHSSDVYKKLLMNILEFVSLQH 171 Query: 187 MMAQQCDLEVGDFVWTGGDTHLYSNHMDQTH 217 +A++ + VG + HL+ + Sbjct: 172 YIAERVGVPVGKYYHFLDSGHLHQKDIKAIE 202 >UniRef50_D1YXV9 Thymidylate synthase n=2 Tax=Euryarchaeota RepID=D1YXV9_METPS Length = 212 Score = 100 bits (249), Expect = 6e-20, Method: Composition-based stats. Identities = 39/220 (17%), Positives = 71/220 (32%), Gaps = 31/220 (14%) Query: 8 MQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDT 67 ++++ G G I G + ++ + K E Sbjct: 17 IKEIYTNGQLVETEYGIKAKCINGMLLEV--RNPVQVWHKKD---PFCTKE--------- 62 Query: 68 NIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDP-DSR 126 + + + + G G Y R + DQ+ + QL+N +S+ Sbjct: 63 RVEFYKKQFKR------ESAGRHGFEYTYIDRL---VNYEGFDQLKWMGEQLQNKRYESK 113 Query: 127 RIIVSAWNVGELDKMA--LAPCHAFFQ-FYVADGKLSCQLYQRSCDVFLGLPFNIASYAL 183 RI W +D M PC F + KL ++ RS D+F N+ ++ Sbjct: 114 RIQAITWMPK-IDCMKKEDQPCFQRIWVFPHKNNKLDVHIHYRSWDMFKAFEANLMAFQE 172 Query: 184 LV--HMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLS 221 LV ++ D +G G + H+Y + L Sbjct: 173 LVKDELI-GPTDFMLGTLRCFGDNVHIYEDDFQAAEEVLK 211 >UniRef50_Q82RC3 Putative uncharacterized protein n=2 Tax=Streptomyces RepID=Q82RC3_STRAW Length = 267 Score = 95.4 bits (236), Expect = 2e-18, Method: Composition-based stats. Identities = 44/224 (19%), Positives = 70/224 (31%), Gaps = 42/224 (18%) Query: 19 NDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFL-------------QG 65 DRTG T+ + P+ + LR+ LW L Sbjct: 33 PDRTGLHTVVRIA-----DPTSDDPVFRAELDRLRTARG--LWPLETVASTLFPAALAAR 85 Query: 66 DTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDS 125 + L E ++ G+ Y + +P IDQ++TV+++L+ Sbjct: 86 SADPDDLAERYRRMYPVIKRYPGNHRGTYFGRLVFYPAASKTGIDQLSTVISRLRTQAAG 145 Query: 126 RRI-------IVSAWNVGELDKMALA------------PC--HAFFQFYVADGKLSCQLY 164 +I I +A + E L PC H Q D ++ Sbjct: 146 TKIAAAYEIDIAAATDQEEAGADLLVHTAGKDNSYIGFPCLSHISLQLD-RDRRVHAAAL 204 Query: 165 QRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHL 208 RS +F N L+ +AQQ +L G G L Sbjct: 205 YRSHFMFERAYGNYLGLGRLLAYIAQQAELACGTLTVMAGHARL 248 >UniRef50_B5UXF2 Putative uncharacterized protein n=1 Tax=Bacillus cereus AH1134 RepID=B5UXF2_BACCE Length = 260 Score = 85.0 bits (209), Expect = 2e-15, Method: Composition-based stats. Identities = 16/149 (10%), Positives = 44/149 (29%), Gaps = 6/149 (4%) Query: 64 QGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDP 123 N ++ ++ + Y + W G +Q+ + +L + Sbjct: 75 NKSENRFDFYKRFQRVYPTLRKVMENNKGTYFGRLVEWNYGRGETFNQLDHTILKLAREK 134 Query: 124 DSRRII-----VSAWNVGELDKMAL-APCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFN 177 ++ R I +S ++ + PC +F + + R+ N Sbjct: 135 NNGRGIRVMYEMSIYDPNLDHNNQMGFPCMSFISLKIRKDFIDLTAIYRNQYFVQKAYGN 194 Query: 178 IASYALLVHMMAQQCDLEVGDFVWTGGDT 206 L+ ++++ ++G Sbjct: 195 YLGLGRLLEFISKESGYKMGKLTCIATHA 223 >UniRef50_C2KJS6 Possible thymidylate synthase n=1 Tax=Leuconostoc mesenteroides subsp. cremoris ATCC 19254 RepID=C2KJS6_LEUMC Length = 168 Score = 84.2 bits (207), Expect = 4e-15, Method: Composition-based stats. Identities = 18/85 (21%), Positives = 36/85 (42%), Gaps = 3/85 (3%) Query: 161 CQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQL 220 +Y R+ D F G+ +I S+ + MA++ +L+VG + + G H+Y L Sbjct: 1 MVVYMRANDAFRGMVSDIFSFTFIQEFMARELNLKVGKYYHSMGTMHIYEPDNQWVKHVL 60 Query: 221 SR---EPRPLPKLIIKRKPESIFDY 242 + + PK+ + + Sbjct: 61 NESNDQTFISPKMPQGNNWAMVHEL 85 >UniRef50_B9PCT2 Predicted protein (Fragment) n=2 Tax=root RepID=B9PCT2_POPTR Length = 57 Score = 80.0 bits (196), Expect = 7e-14, Method: Composition-based stats. Identities = 38/57 (66%), Positives = 50/57 (87%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIH 57 MKQYL+ M+ V + GT+K+DRTGTGT S+FG+QMRF+L +GFP+VTTK+ HL+SIIH Sbjct: 1 MKQYLDFMRHVYEHGTEKSDRTGTGTRSVFGYQMRFDLNEGFPVVTTKKLHLKSIIH 57 >UniRef50_B0YLI9 Thymidylate synthase-like protein n=1 Tax=Glossina pallidipes salivary gland hypertrophy virus RepID=B0YLI9_9VIRU Length = 87 Score = 75.7 bits (185), Expect = 1e-12, Method: Composition-based stats. Identities = 19/79 (24%), Positives = 37/79 (46%) Query: 175 PFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKR 234 P IA Y+LL +M+A C+L +T G +++ +D + P+LI++ Sbjct: 6 PLTIAKYSLLTYMIAYVCNLMPYSITYTMGVSYINKYELDILQSYTKMKQYKFPRLIVEH 65 Query: 235 KPESIFDYRFEDFEIEGYD 253 + I+ + +F + Y Sbjct: 66 YVKDIYSFNLGNFLLYDYQ 84 >UniRef50_UPI0001742C7A thymidylate synthase n=1 Tax=candidate division TM7 single-cell isolate TM7a RepID=UPI0001742C7A Length = 61 Score = 73.4 bits (179), Expect = 7e-12, Method: Composition-based stats. Identities = 25/63 (39%), Positives = 36/63 (57%), Gaps = 2/63 (3%) Query: 202 TGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAP 261 T D H+Y NH++ QL+R+P L K+ I KP + FED +E Y+ +P IK Sbjct: 1 TIIDAHIYENHIEGLKEQLTRKPLKLAKIKIADKP--FNELTFEDITLEDYESYPAIKFE 58 Query: 262 VAI 264 VA+ Sbjct: 59 VAV 61 >UniRef50_C7JA78 Os12g0446900 protein (Fragment) n=1 Tax=Oryza sativa Japonica Group RepID=C7JA78_ORYSJ Length = 89 Score = 71.9 bits (175), Expect = 2e-11, Method: Composition-based stats. Identities = 28/43 (65%), Positives = 36/43 (83%) Query: 152 FYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDL 194 FYV +G+LSCQ+YQRS D+ LG+PFNIASY+LL M+AQ C + Sbjct: 33 FYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCGM 75 Score = 44.9 bits (105), Expect = 0.003, Method: Composition-based stats. Identities = 14/41 (34%), Positives = 21/41 (51%), Gaps = 3/41 (7%) Query: 48 KRCHLRSIIHELLWFLQGDTNIAYLHENN---VTIWDEWAD 85 +R R ++ ELLWF+ G TN + EN ++ AD Sbjct: 10 QRVFWRGVLEELLWFISGSTNAKFYVENGELSCQMYQRSAD 50 >UniRef50_Q5D6W4 Thymidylate synthase-like protein n=3 Tax=Enterobacteriaceae RepID=Q5D6W4_ECOLX Length = 105 Score = 65.0 bits (157), Expect = 3e-09, Method: Composition-based stats. Identities = 24/56 (42%), Positives = 37/56 (66%) Query: 1 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSII 56 M Y +L+++V+ GT DRTG GT+SI+G ++FNLQ+GFP T K ++ + Sbjct: 1 MDNYKDLLREVIITGTDSVDRTGVGTVSIWGAMLKFNLQEGFPATTCKGLAWKAFL 56 >UniRef50_A5VDP1 Putative uncharacterized protein n=2 Tax=Alphaproteobacteria RepID=A5VDP1_SPHWW Length = 260 Score = 63.0 bits (152), Expect = 1e-08, Method: Composition-based stats. Identities = 23/141 (16%), Positives = 52/141 (36%), Gaps = 12/141 (8%) Query: 78 TIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDS--RRIIVSAWNV 135 + + ++ Y ++ P G I+Q+T ++ +LK+ S + +S ++ Sbjct: 94 NVLPKVRNKGDRWSGYYFERMMQLPQLKGEPINQLTDIIRRLKDSSISALNKFELSVFDP 153 Query: 136 GELDKMALAP----CHAFFQFY-VADG---KLSCQLYQRSCDVFLGLPFNIASYALLVHM 187 + +P C +F F + DG +L+ R+ L N+ L+ Sbjct: 154 ARD--VDDSPYGGQCLSFASFKPIGDGSNRRLALTAMYRNHYYIEKLLGNLIGLGRLMAF 211 Query: 188 MAQQCDLEVGDFVWTGGDTHL 208 +A + + G + Sbjct: 212 VAAEAGIAPGPLTILSTHATI 232 >UniRef50_B0YLJ0 Thymidylate synthase n=1 Tax=Glossina pallidipes salivary gland hypertrophy virus RepID=B0YLJ0_9VIRU Length = 115 Score = 60.7 bits (146), Expect = 5e-08, Method: Composition-based stats. Identities = 20/73 (27%), Positives = 40/73 (54%), Gaps = 6/73 (8%) Query: 2 KQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQ-DGFPLVTTKRCHLRSIIHELL 60 +Y L+ +++ G + +S+FG Q+ ++L+ FPL +KR +I ELL Sbjct: 21 NKYPTLVNNIIEHGISTEKK-----ISVFGAQLEYDLRNKKFPLFISKRYDWAYVIEELL 75 Query: 61 WFLQGDTNIAYLH 73 W ++G+T+ ++ Sbjct: 76 WCIRGETDRKNIN 88 >UniRef50_C8SR56 Putative uncharacterized protein n=1 Tax=Mesorhizobium opportunistum WSM2075 RepID=C8SR56_9RHIZ Length = 258 Score = 57.2 bits (137), Expect = 6e-07, Method: Composition-based stats. Identities = 25/152 (16%), Positives = 53/152 (34%), Gaps = 15/152 (9%) Query: 69 IAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRH---IDQITTVLNQLKN---- 121 I L + + +++ G+ G Y ++ AWP GR ++Q++ + L+ Sbjct: 82 IDALTKRYMQVYERRMHRQGEWGR-YFQRMVAWPNGGGRGAGTVNQLSANIETLRAMRSG 140 Query: 122 --DPDSRRIIVSAWNVG-ELDKMALAPCHAFFQFY-VADG---KLSCQLYQRSCDVFLGL 174 ++ ++ +L K C +F + G +LS R+ Sbjct: 141 EAKFFGNVTEIALFDPARDLRKKMNRQCLSFIELKPERQGNIWRLSMMAVYRNHYYVQRT 200 Query: 175 PFNIASYALLVHMMAQQCDLEVGDFVWTGGDT 206 N+ L+ +A + E+G Sbjct: 201 LGNLIGLGRLLQFIANETGFEIGTLTIQSTHA 232 >UniRef50_A5ETP5 Putative uncharacterized protein n=1 Tax=Bradyrhizobium sp. BTAi1 RepID=A5ETP5_BRASB Length = 272 Score = 55.7 bits (133), Expect = 2e-06, Method: Composition-based stats. Identities = 22/158 (13%), Positives = 49/158 (31%), Gaps = 7/158 (4%) Query: 53 RSIIHELLWFLQGDTNIAYLHENNVTIWD-EWADENGDLGPVYGKQWRAWPTPDGRHIDQ 111 +I + LW + T + + + +Y ++ + +Q Sbjct: 70 FTIFPQRLWEMSRGDRSRLFILYRATFPRWQAMNRKANGRGLYFERMVMYGRGPHDG-NQ 128 Query: 112 ITTVLNQLKNDPDSRRIIVSA--WNVGELDKMAL---APCHAFFQFYVADGKLSCQLYQR 166 + +L+Q + RR ++ A ++ + PC F L + Sbjct: 129 LEWILSQFSSRTGVRRSMLQATTFDPARDHVASAQLGFPCLQQVSFEPTAAGLVTNAFYA 188 Query: 167 SCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGG 204 + +F N A L MA++ + + G Sbjct: 189 TQQIFDKAYGNYLGLAQLGAFMAREMGMPLARLNVMVG 226 >UniRef50_A1KLI7 Putative uncharacterized protein BCG_2512 n=13 Tax=Mycobacterium tuberculosis complex RepID=A1KLI7_MYCBP Length = 250 Score = 54.6 bits (130), Expect = 3e-06, Method: Composition-based stats. Identities = 29/159 (18%), Positives = 55/159 (34%), Gaps = 17/159 (10%) Query: 68 NIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRR 127 N L +++ E+ D+ + + +++ I V+ +L P+S++ Sbjct: 68 NSDQLKAMLDFMFNTDTMEDIDVVKSFSRGAKSYHRRIKEGR-MIEFVIERLSLIPESKK 126 Query: 128 IIVSAWNVGEL------DKMALAPCHAFFQFYVA-DGK---LSCQLYQRSCDVFLGLPFN 177 +V + + PC QF + DGK Y RS D + N Sbjct: 127 AVVVFPTYEDYAAVMRNHRDDYLPCLVSIQFRLLPDGKDYVFHTTFYSRSMDAWQKGHGN 186 Query: 178 IASYALLVHMMAQQCD------LEVGDFVWTGGDTHLYS 210 + S A L + + + +G D H+Y Sbjct: 187 LLSIAKLSDWVRENVSARIGRKIMLGPLDGMICDVHIYK 225 >UniRef50_A8P7A1 Putative uncharacterized protein n=1 Tax=Brugia malayi RepID=A8P7A1_BRUMA Length = 83 Score = 43.0 bits (100), Expect = 0.011, Method: Composition-based stats. Identities = 21/76 (27%), Positives = 35/76 (46%), Gaps = 9/76 (11%) Query: 68 NIAYLHENNVTIWDEWADENGDLGPVYGKQW--------RAWPTPDGRHIDQITTVLNQL 119 + + + D GDL PVYG Q + IDQ++ +++ + Sbjct: 8 DENKYLDQFLDECDFSDRSEGDLRPVYGFQGNTVLAEYRGMDADYINQGIDQLSEIIDLM 67 Query: 120 KNDPDSRRIIVSAWNV 135 KN+P +R I++AWNV Sbjct: 68 KNEPHNR-CILNAWNV 82 Database: uniref50.fasta Posted date: Mar 8, 2010 10:38 AM Number of letters in database: 1,040,396,356 Number of sequences in database: 3,077,464 Lambda K H 0.312 0.147 0.428 Lambda K H 0.267 0.0454 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 1,786,953,981 Number of Sequences: 3077464 Number of extensions: 77310530 Number of successful extensions: 184283 Number of sequences better than 1.0e-01: 141 Number of HSP's better than 0.1 without gapping: 364 Number of HSP's successfully gapped in prelim test: 32 Number of HSP's that attempted gapping in prelim test: 182940 Number of HSP's gapped (non-prelim): 454 length of query: 264 length of database: 1,040,396,356 effective HSP length: 126 effective length of query: 138 effective length of database: 652,635,892 effective search space: 90063753096 effective search space used: 90063753096 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 92 (39.9 bits)