Reference sequence (query): batch____ Identities normalised by aligned length. Colored by: property
HSP processing: ranked Search cycle: 3
1 [ . . . . : . . . . 1 . . . . : . . . . 2 . . . . : . ] 264
batch____ bits E-value N 100.0% 1:264 MKQYLELMQKVLDEGTQKNDRTGTGTLSIFGHQMRFNLQDGFPLVTTKRCHLRSIIHELLWFLQGDTNIAYLHENNVTIWDEWADENGDLGPVYGKQWRAWPTPDGRHIDQITTVLNQLKNDPDSRRIIVSAWNVGELDKMALAPCHAFFQFYVADGKLSCQLYQRSCDVFLGLPFNIASYALLVHMMAQQCDLEVGDFVWTGGDTHLYSNHMDQTHLQLSREPRPLPKLIIKRKPESIFDYRFEDFEIEGYDPHPGIKAPVAI
1 UniRef50_C0ZI91 Thymidylate synthase n=24 T... 382 1e-105 1 67.8% 1:264 1:264 MKQYLDLCQRILDEGVIKEDRTGTGTTSVFGHQMRFDLSEGFPMVTTKKLHMKSIIHELLWFLSGDTNVRYLQENGVRIWNEWADENGDLGPVYGSQWRSFTGRDGKTVDQIQWVIDEIKRNPDSRRLIVSAWNPAELDKMALPPCHLLFQFYVANGKLSCQLYQRSGDTFLGVPFNIASYALLTHMVAHVTGLEVGDFVHTIGDAHLYLNHIEQVKLQLTREPKPLPKLVLNPDVTSIFDFKYEDIEIVGYESHPHIKGEVAV
2 UniRef50_P04818 Thymidylate synthase n=326 ... 354 2e-96 1 54.6% 3:264 32:313 --QYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGseEGDLGPVYGFQWRHFgdYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPHPTIKMEMAV
3 UniRef50_C5BMA3 Thymidylate synthase n=8 Ta... 351 9e-96 1 61.7% 1:264 1:277 MKQYLELMRHVRDNGVRKEDRTGTGTVSVFGYQMRFDLSQGFPLVTTKKCHLKSIIHELLWFLNGETNIAYLNNNGVKIWDAWATESGDLGPIYGAQWRSWPAQNGETLDQISQLIEQIKHKPDSRRLIISAWNPALLPdmALPPCHTLFQFYVLEGRLSCQLYQRSADIFLGVPFNIASYALLTMMIAQVTGLAPGDFVHTFGDAHLYLNHLEQVDTQLQRQPLPLPTMAINPAVKDIFGFCFDDFELQNYQAHPHIAAPISV
4 UniRef50_Q4A320 Bifunctional dihydrofolate ... 339 7e-92 1 51.7% 3:263 199:479 --QYLQLISKVLEHGEYRSDRTGTGTVSLFGETMRFNLSTHFPLLTTKRTYWKGIVEELLWFIRGSTNANELAAKNVKIWDGNgnEEGDLGPVYGFQWRHFGayDSQGTDQLQNVIDQIKNNPTSRRIIMSAWNPNALEKMALPPCHLMCQFYVHDGMLSCQMYQRSADIGLGVPFNIASYALLTCLIAHFTNLKPGEFIHVIGDAHVYTNHIDALKTQLKRKPYDFPTIHINNMPKTIFDVTSDDIILNDYKCHPKIHMDMS-
5 UniRef50_Q4U9G5 Bifunctional dihydrofolate ... 339 7e-92 1 49.8% 3:263 242:522 --QYLEILADILNNGYHKKNRTGVDCIAKFGYQMRFDLSQSFPLLTTKKVFLRGIIEELIWFIRGSTNGNELLKKNVRIWELNgrEEQDLGPVYGFQWRHFgdYTDQGIDQLSLVIERIKNNPDNRRLIVCSWNVADLSKMALPPCHLLFQFFVADGTLSCMMHQRSCDMGLGVPFNIASYSLLTYMIAHICGLKPGEFVHNLGDAHIYNNHIDAIKEQISRVPYPFPTLKLNKEITRIEDFTIDDIKVENYRCHPLIKMEMA-
6 UniRef50_Q2TA32 Thymidylate synthase n=5 Ta... 338 1e-91 1 53.4% 3:264 35:354 --QYLGQIEHILRCGFRRDDRTGTGTLSVFGMQARYNLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRdgDLGPVYGFQWRHFgeYSGQGVDQLQKVIDTIKTNPNDRRIILCAWNPKDLPLMALPPCHALCQFYVVNGELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITDLKPGDFVHTLGDAHIYLNHIEPLKTqlQREPRPFPKLKILRKVETIDDFQAEDFQIEGYNPNPTIKMEMAV
7 UniRef50_Q07422 Thymidylate synthase n=6 Ta... 338 1e-91 1 46.6% 3:264 326:610 --QYLDLIADIINNGRTMDDRTGVGVISKFGCTMRYSLDQAFPLLTTKRVFWKGVLEELLWFIRGDTNANHLSEKGVKIWDKNVTRegDIGPGYGFQWRHFgdYTGQGVDQLKNVIQMLRTNPTDRRMLMTAWNPAALDEMALPPCHLLCQFYVNDQklSCIMYQRSCDVGLGVPFNIASYSLLTLMVAHVCNLKPKEFIHFMGNTHVYTNHVEALKEQLRREPRPFPIVNILNkiKEIDDFTAEDFEVVGYVPHGRIQMEMAV
8 UniRef50_Q1Q8B2 Thymidylate synthase n=702 ... 337 2e-91 1 58.9% 2:264 12:290 -QAYLDLLRLVLNEGTEKGDRTGTGTLSHFGAQLRFNLADGFPLLTTKKVHLKSITYELLWFLNGSTHVDYLQQNGVRIWNEWATSegDLGPIYGHQWRNYgqYNSDGVDQIAQVVEQIKTNPNSRRLIVSGWNPGEADQVALPPCHTLFQFFVADNKLSCQLYQRSADLFLGVPFNIASYAMLTHMVAQVCNLEVGEFIWTGGDCHIYQNHREQVELQLTRSLYTLPTLALNPNVKDIFAFNYEDISVDGYESHPAIKAQVAV
9 UniRef50_C3RUB2 Dihydrofolate reductase-thy... 330 3e-89 1 48.3% 3:263 349:629 --QYLGIIYDIIMNGNKQGDRTGVGVMSKFGYMMKFNLSEYFPLLTTKKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWEANGTRenDLGPIYGFQWRHFgnYEDKGVDQLKNVIHLIKNEPTSRRIILCAWNVKDLDQMALPPCHILCQFYVFDGKLSCIMYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQPAQFIHILGNAHVYNNHVDSLKVQLNRIPYPFPTLKLNPEVKNIEDFTISDFTIENYVHHDKITMEMA-
10 UniRef50_O02604 Thymidylate synthase n=87 T... 330 3e-89 1 48.3% 3:263 342:622 --QYLGIIYDIIMNGNKQGDRTGVGVMSNFGYMMKFNLSEYFPLLTTKKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWEANGTRenDLGPIYGFQWRHFgnYEDKGVDQLKNVIHLIKNEPTSRRIILCAWNVKDLDQMALPPCHILCQFYVFDGKLSCIMYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQPAQFIHILGNAHVYNNHVDSLKVQLNRIPYPFPTLKLNPEVKNIEDFTISDFTIENYVHHDKITMEMA-
11 UniRef50_C4Q3X9 Thymidylate synthase n=3 Ta... 329 7e-89 1 50.4% 4:263 296:576 ---YLNLLRYILANGVERRDRTDTGTFGVFGPQLRFSLRneYPLLTTKTVFFRGIVEELLWFIRGSTNSRELAEKNVHFWDANGseEGDLGPVYGFQWRhqTDYTGQGVDQLADVIKLIRERPWDRRIMIVAWNVKDLRKMALPPCHCLVQFYVANDELSCQLYQRSGDMGLGVPFNIASYALLTCMIAHVTGLKPGEFVHTIGDAHIYSNHREALLEQVKRVPRPFPKLEIIREVKNIDDFKFEDFKLIDYKPYPKIPMKMA-
12 UniRef50_A9NG27 Thymidylate synthase n=12 T... 327 3e-88 1 57.6% 1:264 1:288 MKQYLDLARHIMENGTLKSDRTGTGTKSIFGYQMFFDLKDGFPLLTTKKTFLKGIIHELLWFIKGDTNIKYLVDNNVGIWTDwaKKWGDLGPVYGSQWRNFN-----GVDQIEYIINTLKTNPDSRRMVLSAWNPAEIGQMMLPPCHTLIQFYVVDNKLSLQLYQRSGDVFLGIPFNIASYAVFLMMVAQVTGFELGSFVHTIGDAHIYTNHFDQINLQLTRTPRRLPILKINKSITRLEDFKYEDFELVGYDPYPPIKGVVAV
13 UniRef50_Q27828 Thymidylate synthase n=1 Ta... 327 3e-88 1 52.1% 2:264 181:462 -NQYLDMITKIMKEGVSKDDRTGVGTMSIFGQTMRFNLAQSFPLLTTKKVFFRGVVEELLWFLRGNTNGKLLLDKGVKIWEGNGTREydLGPVYGFQWRHFgdYSNQGVDQVKEIIQLLKNNPDSRRIILSAWNPIDLKQMALPPCHVMSQFFVANGKLSCMMYQRSCDFGLGIPFNIASYALLTYMLAKECNLNLGEFVHVLGDTHIYSNHVEALKKQIERVPYPFPLLKIKGN-KSLFDYTYEDFELVGYNAHDKIEMKMAV
14 UniRef50_Q27783 Thymidylate synthase n=25 T... 326 3e-88 1 48.7% 2:264 244:527 -EQYLNLVGRIIDEGCTKCDRTGVGTRSLFGAQMRFSLRNNrpLLTTKRVFWRGVCEELLWFLRGETNAKLLSDKGIHIWDGNGsdEMDLGPVYGFQWRHFgdSEGKGVDQIANIVKSLIENPDDRRMICTAWNPAALPRMALPPCHMMAQFYVSNGELSCMLYQRSCDMGLGVPFNIASYALLTFLMAKASGLRPGELVHTLGDAHVYSNHVEPCRKQLKRVPRPFPFIVFKQDKEFLEDFQESDIEVIDYSPYPVISMEMAV
15 UniRef50_Q4A611 Thymidylate synthase n=15 T... 325 9e-88 1 58.7% 1:264 1:289 MKQYLHLLEHIKTSGTFKKDRTNIGTISLFGLQARYNLKEGFPLLTTKKMAWKAICHELLWFLKGDTNIKYLVDNNVNIWNEwaQKYGELGPVYGKQWRDF-----FGVDQISQVINDIKNNPTSRRLIVSAWNVAQIDKMALPPCHAFFQFYVNDneLSLHLYQRSGDMFLGVPFNIASYSLLLSMVAQVTNLKVGEFIHTIGDAHIYSNHIDQVNTQLERAPYKLPKLILNKNIKNIFDFTFEDIELENYISHETIKAKVAV
16 UniRef50_D2CLW7 Dihydrofolate reductase-thy... 324 2e-87 1 48.3% 3:263 360:640 --QYLNIIYDVMMNGNKQDDRTGVGVLSKFGYMMKYNLAEYFPLLTTKKLFVRGIIEELLWFIRGETNGNILLNKNVRIWEANGTRenDLGPIYGFQWRHFgnYENKGIDQLKNIINLIKNEPTSRRIILCAWNVKDLDKMALPPCHILCQFYIFDGKLSCIMYQRSCDLGLGVPFNIASYSIFTYMLAQVCNLQPAEFIHVLGNAHIYNNHIDSLKIQLNRIPYPFPTLKLNPEIKNIEDFTISDFTIENYVHHDKIAMDMA-
17 UniRef50_O96650 Thymidylate synthase n=17 T... 320 2e-86 1 47.1% 2:264 11:294 -RKYLRQIKHIIDEGDKVIDRTGVGTLSLFGLHSTYSLRNGvpLLTTKRVYWKGVVEELLWFIKGDTDAKRLSAKGVKIWDANGSRegDLGPIYGFQWRHFgdYKGQGVDQLADVIEQIKNNPNSRRIILNAWNVKDLHQMALPPCHTLAQFAVKNGELSCQLYQRSGDMGLGVPFNLASYGLLTHMIAHVCALKTGFLHHVLGDAHVYLNHIDALKEQLSRDPRPFPTVHFEGRIDSIDDFTAESIILNGYNPMAPIKMPMAV
18 UniRef50_Q67JQ1 Thymidylate synthase n=1 Ta... 319 6e-86 1 47.1% 3:263 6:282 --QYLELCREILAegRWTPNRTGMGTVGVFGRMLKHDFKEGFPALTTKKLFFNSVKAELLWFLAGRTDLEFLHERGCHIWDKDAArgGKLGPIYGKQWRAWEGADGRTYDQIAWVIQQIRehPNSRRLVVSPWNVADLEEMALPPCHGPFQFHVKDGRLHLAVWQRSADLFLGVPFNIASYSLLLHMVAQVTGLAVGTYTHYLNDVHIYRNLLDQVRLQLTREPYPLPRLWLNPEVREIDQFTMDDIQLVDYKHHPPIRGELS-
19 UniRef50_B6AE97 Thymidylate synthase family... 318 2e-85 1 48.1% 3:264 267:549 --QYLDMLSNVLQNGHYRENRTGINTYSIFGASMRFDLRESFPLLTTKNVALRIIFEELMWFIKGDTNGNHLLDKKVFIWAGNGseENDLGPIYGFQWRHfdNYNGQGVDQLANLIESLKKNPYDRRHILSAWNPSAVKYMALPPCHILSQFYvnNNRLSCSLYQRSCDLGLGCPFNIASYSLLCVMIAHICGYEPGEFIHFIGDVHIYENHVEQLKQQIKRLPRPFPQLRLKRKVDKVEDFIWEDIEIIGYYPHPTIRMEMAV
20 UniRef50_D2W4C0 Predicted protein n=1 Tax=N... 317 2e-85 1 46.2% 3:264 250:535 --QYLDIIKeiLSDINVREERTGVGTVSKFGYQMKYSLRNnfPLLTTKRVFWKGVAKELFWFISGSTNAKILSEQDIHIWDGNGSREydLGPVYGFQWRHWgdYTNKGVDQLKKCIETLKNNPTNRRIILSAWNVSDLPNMALPPCHLMCQFWVDtnELSCQMYQRSCDMGLGVPFNIASYALLTRLMAQVCNLKPGDFIHTLGDTHVYKNHIEPLKKQIERDPKHFPLLLLDPSITNIDDFKFEHLTLQNYEPHATIKMEMAV
21 UniRef50_Q9UTI7 Probable thymidylate syntha... 315 1e-84 1 45.6% 2:264 331:625 -EQYLNLIRYILENGQSRPDRTGTGTRSVfpPQLRFSLRNnlPLLTTKRVFLRGVLEELLWFIHGDTNANHLSEKGIHIWDGNGSRegDLGPIYGFQWRHFgdYTNKGVDQLAQVISTLKLNPYDRRIILSAWNPLAIPEMALPPCHIFCQFYVSegklSSMMYQRSADMGLGVPFNIASYSLLTHMIAHMCGYEAAEFVHVMGDCHIYNDHLEALQTQLERVPKAFPKLFFKRDAKdiDSFSVDDFAVEGYNPYGPIKMKMSV
22 UniRef50_B1C3H3 Thymidylate synthase n=6 Ta... 314 2e-84 1 53.0% 1:264 1:295 MKQYLEMCKYVLENGEDRSDRTGTGTRSVFGYQTRYDLRDGFPLMTTKKMFIRPIAEELLWFIKGDTNIKYLVDRNVKIWNEWPYEngDLGPVYGAQWRNF---NYEGVDQLAKLVDSLKNDPFSRRHIICAWNPAQVDNMTLPPCHAFLQFYVSADklSCQLYQRSADIFLGVPFNIASYALMVEMLARTCGYEAKEFVHTIGDAHIYKDHFDVVKQQLERKPLPKCKLVLNPEVKSIFDYKIEDIKIEDYQSYGKLVGKVSV
23 UniRef50_Q27713 Thymidylate synthase n=5 Ta... 314 2e-84 1 47.1% 3:263 306:586 --QYLNIIYDIIMHGNKQDDRTGVGVLSKFGYMMKFNLNEYFPLLTTKKLFIRGIIEELLWFIRGETNGNTLLEKNVRIWEANGTRenDLGPIYGFQWRHFgnYKDKGVDQLKNIINLIKNDPTCRRIILCAWNVKNLDQMALPPCHILCQFYVFDGKLSCIMYQRSCDLGLGVPFNIASYSIFTYMIAQVCNLQAAEFIHVLGNAHVYNNHIESLKIQLNRTPYPFPTLKLNPDIKNIEDFTISDFTVQNYVHHDKINMDMA-
24 UniRef50_Q98Q31 Thymidylate synthase n=2 Ta... 313 3e-84 1 56.1% 1:264 1:286 MKQYLDFLKWVLEKGKHKENRTSVDTISAFGYQMRFDLSKGFPLVTTKKTNFSAIAHELLWFIKGDTNIKYLVDNKVNIWNQwaQKHGNLGPVYGKQWRDF-----LGIDQLKKVIEQIKNNPNSRRLIVSSWNPSEIDTMLLPPCHTLFQFYVNDNKLSCHLYQRSADAFLGIPFNIASYALLTFLLAQETNLEVGDFVHSIGDAHIYVNHLEQVKTQLKRNPKELPKLIIKN--KNIFEINFEDIELVDYEFDPIIKGEVAV
25 UniRef50_Q0FG99 Thymidylate synthase n=4 Ta... 310 3e-83 1 53.8% 1:264 1:292 MKQYLDALNYIMDNGEEVSDRTGVGTLSVFGYQIRFNLQEGFPAVTTKKLAWRSIVGELLWFLEGSTDERRLAehKKTIWTANADAQgeLGPVYGHQWRHFDGTDKdsTDQIIWLINEIKNNPDSRRMILSAWNPNQINEMALPPCHTMAQFRVMNGKLSCQLYQRSADMFLGVPFNIASYSLLTHMLAQLCDLKVGSFVWVGGDCHIYKNHKKQVLEQLKRTPKSLPNLEM-PSFSNLDElrPIGYVLKNYDPMDSIKAPMAI
26 UniRef50_Q76YC2 DTMP synthase n=1 Tax=Aerom... 307 2e-82 1 44.3% 1:264 1:277 MKAYLDIINYTFENGEDEMDRTGVGTRSVLGQVFRHDMADGFPAVTTKTLAWKAVRGECLWFMNGFTNVEVLRAMtkTIWDDNFntDGELGPVYGKQWRDFN-----GVDQLAKAIERIKTNPECRRNIVCAWNPVDLDKMALPPCHVLFRFSVKRGRLNLTWYQRSVDTFLGLPFNIASYGLLLEIVAQITGYKAGILTGMLDDTHIYHNHFEQVQEQLQREPHKLPTLKFKNRFTTLEelSVDDIELEDYKCHSAIKAPMAV
27 UniRef50_Q8WYK3 Thymidylate synthase n=4 Ta... 301 1e-80 1 49.2% 3:264 32:279 --QYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGseEGDLGPVYGFQWRHFGAEYRDME--------------------------SDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPHPTIKMEMAV
28 UniRef50_P00471 Thymidylate synthase n=17 T... 298 1e-79 1 47.3% 1:264 1:286 MKQYQDLIKDIFENGYETDDRTGTGTIALFGSKLRWDLTKGFPAVTTKKLAWKACIAELIWFLSGSTNVNDLRlqGKTVWDENYENqgELGPIYGKQWRDF-----GGVDQIIEVIDRIKKLPNDRRQIVSAWNPAELKYMALPPCHMFYQFNVRNGYLDLQWYQRSVDVFLGLPFNIASYATLVHIVAKMCNLIPGDLIFSGGNTHIYMNHVEQCKEILRREPKELCELVikEQLKYVLKLRPKDFVLNNYVSHPPIKGKMAV
29 UniRef50_Q04FR4 Thymidylate synthase n=279 ... 297 2e-79 1 50.2% 2:264 6:319 -EQYLNLARRILETGASKMDRTKTGTHSIFGAQMRFDLSEGFPLLTSKKVAFGRIKSELLWFLRGDNNIRFLLQHHNHIWDEWPFKkgTIGDVYGKLWRHWPDANDDgvDQITRLINEIKVNPNSRRLILTAWDPETTPFATLPSCHVMSQFYVVDGKISLQMYQRSADYFLGVPFNIASYSLLLSMVAAQTGLEVGEFIHTIGDAHIYNNHVDQIKEQLSKPTHKLPTLKLNPDVKSIFDYEMSDIKLENYIHEDVIKAPIAV
30 UniRef50_Q4PBV6 Thymidylate synthase n=3 Ta... 297 2e-79 1 47.7% 3:264 260:554 --QYLELVQRVISTGESRPDRTGTGTLALFAPqlRFDLTNglPLLTTKRVFFRGVLEELLWFVGGKTDAKLLTEKSVHIWDGNGSreGDLGPVYGFQWRHFgdYAGQGVDQLASVIDKIRNNPTDRRILLSAWNPADLELMALPPCHMFAQFFVSnkHLSCQMYQRSCDLGLGVPFNIASYALLTYMIAKVTDCEPKELILAMGDAHVYKDHVQPLKAQLERDPLPFPKLKIERDVKDIDDFTFDDFVVQGYKCHGKIDMKMSV
31 UniRef50_Q3J0W9 Thymidylate synthase n=12 T... 296 6e-79 1 51.0% 2:264 6:298 -QQYLDLLAQTLERGDRRVDRTGVGTLSLFGAMLRFDLSGgvPILTTKRVYWKTAVKEMLWFLTGGTNIRPLLQENVRIWSDwaARWGELGPVYGKQWRRWLGPDGHEHDQIAALIETLRTNPSSRRMLFHAWNVAEVGQMALPPCHMVYQYHVtdGRLNALLYQRSVDLLLGAPFNFVGAAALQLMIAQQAGLVPGDLVWVGGDTHLYLNHLDQAREQTGRAPRDWPRMRLLRRADSIDDYRIEDFAVEGYDPHPAIAAEVAV
32 UniRef50_A5KSZ1 Thymidylate synthase n=1 Ta... 294 3e-78 1 46.6% 3:264 7:279 --QYLQLMADILKDGRSKPSRGIHGLKAIFGYQIRFDMRQGFPLLTTKKMPFKILLHELFWFISGSSSVDYLHEHKIHYWDGFLHEgdDLGRVYGVQWRHWLRPDGSQFDQLQWAIEQIKTNPNSKAIIVSAWnpNDYGDMRLPPCHTMFQFDVTGGKLRMQLYQRSSDVFLGLPFNIAQYAMLLHMVAYLADLEPRELIISIGSAHLYRNQIEPAKEQVRRKPYRFPKLTIAGDVKDIDDFKEKNFSLEGYQSHPHIKTDLVI
33 UniRef50_A2R2F6 Thymidylate synthase n=20 T... 292 5e-78 1 48.5% 3:264 39:356 --QYLNLIRRILSEGEHRPDRTGTGTRSIfpPQMRFSLSKplPLLTTKRVFLRAVLAELLWFISGTTSSLPLSEAGIKIWDGNGSRegDLGPVYGFQWRHFgdYSGQGVDQLAEVVKKLKENPFDRRIIMSAWNPKDMRIMALPPCHMFAQFYVrrGHLDCLLYQRSADMGLGVPFNIASYALLTHLLAHAVDMVPGTLVHTLGDAHVYLDHVDALKEQIEREPVAFPEVRIKREDRgvDGWKEEEFEVIGYKPHKAIKMKMSV
34 UniRef50_D2XB64 Bifunctional dihydrofolate ... 289 5e-77 1 42.9% 3:263 163:443 --AYLSLLSEVLYSGEKRKDRTGTGTRSLFGRHLLFEnsEKFPLITVKRMAWGCILSELLWFLSGSTDSKMLELQNNNIWKKNSSreGDCGPIYGFQWRHWgdYRGQGEDQILSIISEIQNNATSRRLVLSAWNVSDLDKMCLPPCHSFSQFYVRGDFVDCHLYQRSADLALGVPFNIASYACLLSIIAEASGKKAGNLTMSFGDVHIYETHIDNAQKMLERLPHKTPKLKVKISDNTLFCLKKGDFELDGYSCCGALQFDMA-
35 UniRef50_Q2G6V6 Thymidylate synthase n=14 T... 289 8e-77 1 52.3% 3:264 14:314 --QYLDLMRRIWEHGDERVDRTGVGTRSVFGAELRFDLSDGrpLLTTKRVYWKTATREFLWFLTGNTNIRPLCAQGVEIWTDwaLRWGDLGPVYGKQWVDWprRREAGVNQVADVVDSLRHNPGSRRHIIEGWNVAEIDRMALPPCHKTYQFHVSGNRLNGLLYQRSCDVALGLPFNLWGAALLVRLLAQQCDLQPGELVWMGGDTHLYLNHADLVEAQLSREPEGDPRLAILRRPDSIFGYRIEDFEVTGYAPQGHLSAPVAV
36 UniRef50_Q6QGJ5 Putative thymidylate syntha... 288 9e-77 1 49.8% 1:263 1:278 MQQYLKILTDVILLGEPRNDRTGTGTVSIFDSYAKFDLREGFPAVTTKRLAWKSVVGELLWFLSGSTNLHDLreGQWTIWTPNYEdkGNLGPVYGKQWRNF-----GGRDQILELIEGLKNNPHGRRHLVSAWNVAELDKMALPPCHYGFQCYVsdGYLDLKWTQRSVDCFLGLPFNIASYALLTHILAKLTGLKPRYLIFSGGDTHIYNDHMEQVEEQVKRKPRPLPTLVM-PEFVDLYDLLENnfHLEGYDPHPALKAKMS-
37 UniRef50_D1BNV6 Thymidylate synthase n=4 Ta... 286 5e-76 1 37.8% 3:264 7:263 --QYLGIIENILDHGIYGQNRTGIATYKLPQQIMQFDLQEEFPILTTKFVAFKTAVKELLWIWqqSNDVRKLQEMNVHVWDEWMREDGTIGKAYGYQIAKYK--------QLDKLIKTIKEDPDSRRMIVTLWNIEDLDDMALQPCAYETLWDVGDGYLNCMLIQRSGDMGLGVPFNTAQYAALQCMIAQVTGLKPGKFTHVINNAHIYENHVDALREQLARRNqpAPKIIVNPEVKDFYDFTPEDITLDGYEHLGKLSMTVAV
38 UniRef50_A3QU09 Thymidylate synthase n=1 Ta... 282 7e-75 1 44.5% 2:264 30:321 -RNYLSLVRTVLKAP-SSPNRTGIDARSSFGHQLRFDLRNGvpLLTTKPMPFKTILRELFWFLRGETNQKILERQNVHIWKGNSSReeSLGPIYGFQWRHFgdYTNKGVDQLQQVIRTIKEDPTSRRIIMSAWNPVDLDKMALPPCHILVQFHVnnGELSAQLYQRSADLMLGVPFNIASYSILVHLIAKICGLKPGYFIHSLGDVHIYENHVSGAKEQLTREPQRQPYLNIDIDPTllEQLSCDQFKLVNYKYNppIKLEMAV
39 UniRef50_Q65J44 Thymidylate synthase n=9 Ta... 281 2e-74 1 36.1% 2:264 6:279 -QQYNAIIQKIIESgkWDSDGTPAHTLSIMSEKMRFDNSE-VPILTTKKVAWKTAIKELLWIWqkSNDVQVLNDMGVHIWDQWRLEDGTIGAAYGYQLGKKNRtnGQKVDQVDYLLHQLKHNPSSRRHLTMLWNPDDLDGMALTPCVYETQWYVKEGKLSLEVRARSNDMALGNPFNVFQYNVLQRMIAQVLGYELGEYIFNIGDCHIYTRHIDNLNIQMKREQYEAPKLWINPDIKNFYDFTIDDFKLIDYKHGDKLTFEVAV
40 UniRef50_B2YFY9 Thymidylate synthase n=1 Ta... 274 2e-72 1 40.0% 4:263 10:293 ---YLTLVRRVLRDGTLKSNRTGVDTKYIFGDQLRYDLRDNRimLTTKKVFFRSALEELLWFLRGDTNQANLAAKGVNIWRGNSTReeSLGPIYGFQWRHFgdYTGQGVDQLAQCMHQIQYEPSSRRMIMTAWNPNDLDKMVLPPCHMSIQFSVNegELSGHMTQRSADLMLGVPFNLVSYSLMLHILAHKFGLKAGELVTSYGDLHIYVPHIKNAMRQVSRLPYASPQIELkgRDKRVEELTVDDFAVKNYRHHSQLEYEMA-
41 UniRef50_A6M378 Thymidylate synthase n=8 Ta... 270 3e-71 1 36.6% 3:264 7:263 --KYLAIANDILENGYFDNNRTGVKTYKLPHQIMQFNLEKEFPILTTKFVAFKTAVKELLWIFkqSNSVKELQSQNVKIWDEWMMEDGTIGTSYGWIVKKF--------DQIDKLIDALKNNPQDRRMMINLWQIPYLDSAPLYPCCFLTMWDVTDGKLNCMLVQRSGDWGLGVPFNTSQYAVLVHLLAQVTGLKPGLFTHVINNAHIYENQVDGLKLQLTRKnyNAPKLWINPEITNFYDFTPDDIKLEDYKHHESIKMDVSV
42 UniRef50_A9UZA9 Thymidylate synthase n=1 Ta... 265 1e-69 1 54.2% 64:264 31:276 ---------------------------------------------------------------NCNTNANDLAARDVHIWDANGseEGDLGPVYGFQWRHFgdYSGQGVDQLAEVIEQIKTNPDSRRIIMSAWNPLDIPKMALPPCHTMCQFYVCDGELSCQLYQRSADMGLGVPFNIASYALLTYMIAQVTGLKPGDFVHTIGDAHVYLNHVDALEEQLKREPRPFPTLSFKRDIEeiDDFKFEDFDLQGYKPHNRIAMDMAM
43 UniRef50_Q88CN9 Thymidylate synthase n=74 T... 263 3e-69 1 42.0% 1:264 1:323 MKQYLDLVRDVIDNGTLQGNRTGIRTISLPGAMLRFDLQKGFPAITTRKLAFKSAIGEMVGFLRGVKNAGEFRELGCKVWDQNANEndDLGEIYGVQWRQWPGYKrkAIDQVRQCLDTIANDPGSRRILFHGWNCAQLDEMALPPCHLLYQFhvETREISLTLYIRSNDLGLGTPFNLTEGAALLSLFGRLTGYTPRWFTYFIGDAHVYENHLDMLNEQLKREPLEAPKLVISdePEWLEKIEPSDFWLEGYEHHAPMTAPMAV
44 UniRef50_Q5UQG3 Thymidylate synthase n=1 Ta... 261 2e-68 1 40.2% 2:262 273:561 -NQYIELVKTIMEKGIVKQTRNSI-TKSIFGYQLKYDLSKGYPIQTIKRSYPKAIFEELMWMIRGQTDVSILQKKGVHVWDKNSseEGDIGPGYGFQMRYWGayQGQGIDQLNKCIESIQNNPHDRRIMINLWNCSDLDKMALAPCHFCYMFGvkKGRLNCHLVQRSWDVLLGW--NTTTAALLTYLIANHCDLDPGILVHSISDAHIYQSHIdaISQLLQRKCRKFPNLVIRNKKEKIDDYEFDDLIIENYYPCPSISAEM--
45 UniRef50_A8RRN6 Thymidylate synthase n=16 T... 259 5e-68 1 34.2% 2:264 17:287 -QIFIQNCNDILEHGVWdeDGTPAHTIKRFGIVNRYDLTREFPVITLRRTAFKSAVDELLWIWQKKSN--NIHDLNSHIWDSWADENGSIGKAYGYQLGVKHHYKEGDFDQVDRILYDLKHNPLSRRIMSNIYNHHDLCEMNLYPCAYSMTFNVSGNTLNGILNQRSQDMLTANSWNVCQYAVLLHMLAQVSGLKPGELVHVIADAHIYDRHIPMVEELLKREPYPGPTLSMDTSIQNFYQFTTDSFRLEHYQYHtsGKIPVAI
46 UniRef50_B6FSV1 Putative uncharacterized pr... 257 2e-67 1 32.3% 2:264 6:282 -KVFIDMCRDIIDNGVSTedGSFAYTLKKFCVVNRYDLSKEFPALTLRRTGIKSCVDELLWIWQRKSN--NVHDLKPHIWDSWADEDGSIGKAYGYQMSVKHQYKEGMMDQVDRVIYDLKNNPYSRRIMTNIYVHQDLHEMNLYPCAYSMTFNVTKKnlNGILNQRSQDVLAANNWNVCQYAVLMHMLAQVCDMQVGEFVHVIADAHIYDRHIPLVEELISREPLPAPTFWLNPEVKNFYEFTPDDVRLDNYETGSQIkiPIAV
47 UniRef50_Q6WIC0 DTMP (Thymidylate) synthase... 256 6e-67 1 41.8% 1:263 2:300 MKNYLQLCTEILNEGDFLENRTGTNTVSVISRELRWDLSKGFPLLTTKKMATKAIFGELLWFLSGSGLISDLRKYTecIWQQNLDeeDDLGYVYGKVWrdKEVTEFDQIHQLLCDIAAVKEDPTqrRMIVEAWDPYFHTEsaLPPCHYGFQVFVRNGKISLKWNQRSVDTFLGLPFNIASYALLVHILAQLTGLKVGELIFSGGDVHIYEDHIVQVLKQLRRTPRELPQIQL-PEFDTLSQlrASDFVVYDYDPYPALKGKMS-
48 UniRef50_C4Z7Z1 Thymidylate synthase n=19 T... 256 8e-67 1 31.6% 2:264 6:282 -KVFVAMCQDILENGTSTedGTSAYTIKKFGVVNRYDLSKEFPAITLRKTYIKSATDELLWIWQKKSN--NIHDLKSHVWDEWADEDGSIGKAYGYQLGVKHQYKEGMMDQVDRVIYDLKHTPFSRRILTNIYVHQDLHEMNLYPCAYSMTFNVTQKklNGILNQRSQDVLAANNWNVCQYAVLMHMLAQVCDMRVGELVHVIADAHIYDRHVPIVKELIERPQYDAPKFWLNPDIKDFYQFTTDDIKITDYVTGEQIkiPIAV
49 UniRef50_A8H1B4 Thymidylate synthase n=132 ... 252 1e-65 1 34.8% 1:264 1:283 MKQYLDLCQRLIDEGTWVEnrTGKRCLTVINADLVYhdKNEFPLITTRKSFYKAAIAELLGYIRGYDNAADFRAIGCNTWNANANDndDMGRVYGVQGRAWSKPDGGCIDQLRKIVDDLSKGIDDRGEILSFYNPGEFHMGCLRPCMHTHNFSLVGDTLHLTSFQRSCDVPLGLNFNQVQVFTLLALMAQITGHKPGTAFHKIVNAHIYEDQLELMQeqLKREPFTSPKLVINPNIKSLEDlsIDDFEVTGYEHHEAISYPFSV
50 UniRef50_Q8RGP6 Thymidylate synthase n=10 T... 249 8e-65 1 32.7% 2:264 7:275 -KIYKDIVDTIAEKGIWSedGTAAHYKSYIGYQFRLDNSDDehLITSRFAPSKAPIRELYWIwlQSNNVDVLNELGCKFWDEWKMQDGTIGKAYGYQIAQ---ETFGQKSQLHYVINELKKNPNSRRIMTEIWIPNELSEMALTPCVHLTQWSVIGNKLYLEVRQRSCDVALGLVANVFQYSVLHKLVALECGLEPAEIIWNIHNMHIYDRHYDKLIEQVNRETFEPAKIKINN-FKSIFDFKPDDIEIIDYKYGEKVSYEVAI
51 UniRef50_Q8WYK4 Thymidylate synthase n=7 Ta... 247 3e-64 1 54.1% 93:264 58:230 --------------------------------------------------------------------------------------------VFGMQArsLRDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKIQLQREPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPHPTIKMEMAV
52 UniRef50_B9CJY5 Thymidylate synthase n=10 T... 247 4e-64 1 30.5% 3:264 7:282 --IFTAMCSDIIEHGTTteDGTPAYTIKKFGVCNRYDLREEFPALTLRRTALKSAMDEVLWIYQKKSN--NVHDLNSHIWDAWADESGSIGKAYGYQVGQKSHYAEGDFDQMDRVLYDLQNNPFSRRIMTNLYTFADLSEMNLYPCAFNAIYNVTQntLNLLLVQRSQDILAANNWNVCQYAILLMMVAQVSGMQAGELVHMISDAHIYDRHVDIVRELISRPIFAAPHVSLNPDVTDFYAFTTDDLIVENYEHGPQVkiPIAV
53 UniRef50_B7C7C1 Putative uncharacterized pr... 247 4e-64 1 34.2% 4:263 8:286 ---YCGLCKDILENGVQVHNRTGIDTIKIPSAHFHLDVSKEFPILTTKQLFIRQAVTEMLWIYqqSNDVRWLQERNVHIWDKwiNEDGDwdPSFAHTIGTAYGYIVKKYDLMNKLLNSLKNDKEDRRRVISLWQDSELDTAVLPSCVWSSEWDVTDGKLNIWVHQRSCDVPLGLPFNVTQYAVLLMMVAQVTGLKPGTIDWSIKDAHIYVNQVDGIKEQLNRYEtpAPELWLNPDVTDFYDFDpkDVKLNGYEHMGKISFPLA-
54 UniRef50_C6JM98 Thymidylate synthase n=6 Ta... 243 4e-63 1 31.2% 2:264 8:276 -KIYKEIVEIIDKNGIWSedGTPAHYKSYIGYQFRLDNsdEAHLITTRFAPNKAPIRELYWIwmQSNDVDELNKLKCKFWDEWKMNDGTIGKAYGYQI---AKQTFGYKSQLDYVIGELKKNPNSRRIMTEIWVPEDLDKMALTPCVHLTQWSVIGNKLYLEVRQRSCDVALGLVANVFQYSILHKLVAMECNLEPAEIIWNIHNVHIYDRHMPDLLEQIKRPSIDGATVKIEN-FKSIYDFKPDDVVVENYQYGEKISYEVAI
55 UniRef50_D2RRK7 Thymidylate synthase n=9 Ta... 242 1e-62 1 43.7% 1:263 1:337 MRQYLELVDTVLSEGTYKPNRTGVDTISSFSEHYEVDLQDGYPLLTTKQmrWNSMLHEVCWYLSGEEHIRDLREET-KIWDAWADDEGRLDTAYGRFWRRFPIPEDdtFDQLQYVIDTLSDSPNSRRLVVNAWHPANAAVSTLPPCHYSFVFNAQGDRLNCHLTQRSGDTALGIPFNIAAYALLTKVIAQQTGFKPGTFAHTVVDTHVYcdHVPGLLEQLSREPLERPTLEVADV--SIDELAYEDVELKNYESHEGIEFAVA-
56 UniRef50_UPI0001925B1E PREDICTED: similar to thymi... 242 1e-62 1 44.0% 24:264 1:197 -----------------------TGTLSIFGGQMRFNLRESFPLLTTKRVFWKGVVEELLWFISGSTDGNILAQKGVQIW-----------------------------------------NSNGTREFLDKCN---IPLMALPPCHSFCQFYVANGELSCQMYQRSCDMGLGIPFNIASYSLLTYIIAHVCNLKPGDFIHTLGDAHVYNNHVSALKEQIGRSPRPFPKLNIKRKVENIDDFKSDDFELIGYNPHQKIKMAMAV
57 UniRef50_C3IV33 Thymidylate synthase n=2 Ta... 239 8e-62 1 32.9% 19:264 49:306 ------------------EDGSPIATKRIFGVVNRYDLSKEFPAPTTRPLPLKTIFDEVDWIYRKRSN--NVNDMRAKIWNQWaeKKGSIGEAYGYQV---AKPIFGYDNQMDYVLGELKRDPFTRRAVIEMWNVDDTGRMNLPPCAHHLQFWSDGKKTNLILKQRSQDFVTANAFNVCEYAILLHMVARHIGQEVGELLHIIGDCHIYNKHLELAEELVKREPYAAPTLWINPEKTDFYSFTADDFRLENYDKHPQMKIEVAV
58 UniRef50_Q934U8 Putative thymidylate syntha... 238 1e-61 1 43.3% 4:264 23:371 ---YAKVVETVLNSGVHAGDRTGTGTKSVSYVPSYYMLTGgvPLISGKAVNLKPLLVELEWYLKGTGNIQFLKDNGVKIWDAWADENGDLGPVYGKQWRRWEDTrsREIDQLQRIVHTLRTNPTDRRILLNAWNVGELEDMKLPPCHFVFSLwiQHNrlNSCLVQRSVDTFVGMPFNIAGYGILTHFLAKITGHMAGAFVHFGFDVHLYDNHMGGVEELMKREPPkdPVVIFPHEWAELDDFKWEGVQVCGYSPLPWIKVPVAV
59 UniRef50_A8E2Q5 Putative thymidylate syntha... 234 3e-60 1 33.8% 2:264 5:315 -KIYKDLVMDIIKNGvvYADGTPATTKFIEGVNFTITPDMGAPLLRSKHVGIKWALTELQWIWqmSNEVSWLKERGVTIWDEWEQEDGTIGKAYGygWIAGTHQPYLKLNQVEAVIEQLKSTPNSRRIMTTLWNVEDLYDMSLEPCVWTTHWTVVEGKLNLHVKARSSDVCLGLPFNIIQYHALQLVMANTVGLELGNLYWTSDNAHIYERHLELVEKQVNEppEEVPKLVLpkKGTNFFDSPLSDISVINYKHNGKFNYEVAI
60 UniRef50_B9LR89 Thymidylate synthase n=4 Ta... 229 1e-58 1 44.5% 1:263 1:341 MQQYLDLVDDTLSTGTYKPNRTGVDTIATFSGQYTVDLSEGFPLLTTKKmrWNSLIHEVLWYLSGEEHIRDLREET-KIWDAWADDEGRLDTAYGRFWRRFPVPDgrTFDQIQYVLDTLDENPRSRRMVVNAWHPANAAVSTLPPCHYTFVVNVQDGRLNLHLTQRSGDIALGVPFNIAAYALLANALAQRTGFEIGEFGHTVVDAHIYcdHVPGLLEQLSREPRERPRIEIADKP--LDELTYEDIEVVDYDSADGISFAVA-
61 UniRef50_C5H7L6 Thymidylate synthase n=3 Ta... 225 8e-58 1 33.7% 4:264 8:297 ---YKNILNHVLSVGELRTTRTGDVISAFAPPKFRFDMRTGFPLLTSKQVFTRQVIGEALWFLNGENKLGELRYRTWgrWTIWSDDFKRwgRIYGVQWRNFEGHNGCVVDQLETLVTKMKGDITDRYMLVNAWNAADinSMALAPCHVLFQIYITngEVDLQWYQRSVDTFLGLPFNIASYGFILEVLCKMTGYTPRYLIGVFGDTQIYQNHMKQVYELMNNEEFHAPTFEIGVQLNTLSDLKhsDFiiNNYQHAGKIEAPLSV
62 UniRef50_A2SMX7 Thymidylate synthase n=1 Ta... 218 2e-55 1 32.1% 1:262 1:314 MQQFHDMLQHILDHGSRQLnrTGEEVLFVPGYTLRFDMADGFPAITTKQLFFKMAKGELFGFFRGFTSAAQFREIGCTVWNDNadDLGRFGYLQWTDWRDWREAtrRSINQLETSLHAVMTNPSDRGIILSGWNPAEIDQGALRSChyMLQVDVATGTLHLTLWQRSFDAPLA--YNVAIGAMYLEIMARLAGLKAGTFTHFISDAHIYAKHIPGVKEMLAREHFPQPTLDLGNIPTlfATLDPNQVKLVNYQHHPKIAFEM--
63 UniRef50_C7HUX5 Thymidylate synthase n=2 Ta... 215 1e-54 1 26.5% 2:254 5:276 -EKYIKIAKEILEKGYDEedGESAYTKYLPQQVVRYE-KGELPLISLRKIAWKSAIKEILWIYqrSNDVNLLKeyKVNYWDSWKNEDGNLGTAYGYQikFKSPETGQMTNQIERLIDQIKNNPLNRRLIMNLIDVDDMADMTLIPCAFLTMWTVSGEYLNLTLVQRSGDFLAAagINAFQYYVLLRMVAQVTGYKAGDFVHFIQNYHIYKKHIPSVKKIlkVDEKSKPRLEINPDIKEFKDFTIDDFKLIDYYP----------
64 UniRef50_B8QTX3 Putative thymidylate syntha... 215 1e-54 1 34.6% 2:264 6:310 -QQYKAFTANILSNGELRHSRSGNTISVPFPEDLRIDVRKEFPLLTCKSVPMSLVAGELLWFLAGKTDLHSLRMYqnTIWTADYErqEDLGMIYGSQWREFESCD-TTCDQITRLIEGIKENPASRYHIVSAWNPVAVANnaLPPCHMFFQVYASEgyMDLRWYQRSVDTFLGLPFNIASYALLLRILAQMTGYTARYVIGSFGDAHIYENHVPAVMQMMDNPEFDAPTLKLDnsLDSVLKLNGLVFklQDYQNAGVVKAPLSV
65 UniRef50_Q03LN3 Thymidylate synthase n=75 T... 205 2e-51 1 27.1% 3:264 7:286 --IFKENITKIMEEGVWSedGTTANSKYITGSFAEYDLSKgfPITTLRPIAIKSAIKEVFWIYQDQTNSLDVLeyNVHYWNDWEVEGVPANNGDKRSIGQRYGAVVKKHDIINRLLAQLEANPWNRRNVISLWDYEAFEETalQPCAFQTMFDVrdVYLDATLTQRSNDMLVAHHINAMQYVALQMMIAKHFGWKVGKFFYFINNLHIYDNQFEQAEELLKRQPSdqPRLVLnpDETNFFDIKPEDFELVDYDpkPQLKFDLAI
66 UniRef50_B4Y380 MilA n=1 Tax=Streptomyces r... 204 2e-51 1 21.9% 3:239 12:254 --AYLSQLRDIYHSPEFRNAPRGQASRERIGAGFRLLDPVQRHivPARRANVVFNFAEALWYLSGSDRLDFIQYYAPGIAAYSADGRTLRGTAYGPRIFRHPA---GGVNQWENVVKTLTDDPDSKRAVIQIFDPRELadNIDVACTLALQFLIRDGLLCGIGYMRANDAFRGAVSDVFSFTFLQEFTARYLGLGIGTYHHVVGSVHIYDSDARWAERVLDagPRpfPAMPDGDNWPHV-------------------------
67 UniRef50_Q13T72 Thymidylate synthase n=4 Ta... 204 2e-51 1 21.7% 2:255 14:268 -KVYGRLLRK---RGSDDINPTKGPATEINGALLVLKKPRARLSQSEKKNTLFSCLGEFLWYLAGSDKLDFIQ-YYISRYKDFSDDGKTVFGAYGPRLFGPTS----GTDQVQNVIQTLRANQHSRRAVIQLFHGDDLAAneDLPCTCTLQFFIRNYQLNAMVTMRSNDAFMGLPHDIFAFTMLQELIARSLGVEVGQYKHAVGSLHLYANNTQAVNDYLAEGFQemPPMPAGDPWPAVErlKAENTIRQGKQPN---------
68 UniRef50_B2IB94 Thymidylate synthase n=2 Ta... 200 3e-50 1 24.0% 1:242 1:247 MEIEKECLDAILYnsIKEHGRTNAgtVELLGVALRILKPRARISRSENRGKPFSAIGELLWYLSGLDTLAFI-EPYVSAYRDDA-VAGVIQGAYGPRLRAM----RDGIDQFASIETLLRQKPNSRRAVIQLFNAEDitEHKEIPCTTTLQFHLRDGLLHMSVTMRSNDAYWGLPHDVFCFTMIQEMMARRLGVELGEYYHYVGSMHVYEKHLNHLDNYLVEGFqeMPPMPAGDPFQLVDHL----------------------
69 UniRef50_B0T6R4 Thymidylate synthase n=1 Ta... 199 8e-50 1 20.2% 10:251 17:256 ---------KLLLKSKMRVSATKGTTVEEHGVVLELTRPRARLSRAHMKGHVFSCIGEFIWYISCSNRLEPV-EYYISRYKKFAEKDGTVWGAYGPRIF------GGDRSQYEVVKEMLSERPSTRKAVIQLFDREdlQDYNDIPCTCTMQFLVRDGMLNLVVHMRSNDVYMGLPHDIFAFTMIQEILAHDLGFKLGTYKHMVGSFHLYDHDREKVEQYLKEGFQpmPAMPSGNQWGHITalKIEDAIRRG-------------
70 UniRef50_B4TEI9 Thymidylate synthase n=2 Ta... 199 1e-49 1 22.6% 6:244 16:256 -----DVHQAILADGLS-NDPTKGSTLEILGAYLVLTDPRRRISRTESRGKLISCLGEFLWYLSAQNDLEFIKHFIPR-YAESAESDGKIHGGYGPRLFNM----RGLYNQLKNVINLLQEKKPTRRAVIQLFDASDlrEYVDIPCTISMQFIVRCEELHLFVCMRSNDAFMGLPHDVFAFTMLQELVARLIGCELGHYHHFVSSLHLYKNDLEKVKALQKEGfsTLPVMGSMPEMHSLDDILP--------------------
71 UniRef50_B2HI72 Thymidylate synthase, ThyA_... 196 6e-49 1 21.2% 6:250 12:260 -----DLLReiREQGQPVL-PTRAPTRELIGVSLELTEPRCRLSRTEARRLSRTGIAQLAWYLSGTTNPEMILHWVPN-HRNELEADGTIHGAYGPRMFGTGDNA-----QFCTVLELLKTSSSSRRAVIQLFDATDLtrYKDVPCTNTLQFFVRDSRLHLMVTMRSNDAYIGLPLDVFAFTMLQELMAGELGIGIGRYIHSVGSLHIYEYniDFLAEGWQSTDTPMPAMPAQSLTRHVPQFLASELQIR--------------
72 UniRef50_C8S1P3 Thymidylate synthase n=1 Ta... 194 2e-48 1 18.4% 6:250 11:275 -----DLMRVVFKqgNFVVDSSKGKSTEVFGALLELKNPRARLSRSFSKAKAFSPLGELFWYLSGSDRVEFIKHYIPN-YPKLIKDEVTANGAYGPRIFGKEaaKRDGASEWDRVIRTLREREGSRNALVQIYDNSdkPKNGDKPCTCTIQFAIRNGQLLMHTHMRSNDAFFGLPHDVFTFTMLQEIAARELGLGLGRYSHSVTSLHLYHDsaEAYYREGFHDYSPMPEMPLGNPWKSIEQVKIAEHQIR--------------
73 UniRef50_Q6X183 Thymidylate synthase (Fragm... 194 3e-48 1 50.0% 111:264 1:166 --------------------------------------------------------------------------------------------------------------QLVKTIDRIKALPNDRRQIVSAWNPAEIDQMALPPCHMFYQFNVRNGHLDLQWYQRSVDVFLGLPFNIASYAALTHIVAKMCNLIPGDLVFSGGNTHIYSNHVEQCKEVIRREPKELCSLEieNWPTKIqtMTHTDFVLKNYESHPAIKAKMAV
74 UniRef50_Q03W75 Thymidylate synthase n=13 T... 192 9e-48 1 20.0% 3:242 10:252 --AYIAELNEIYHHAEFFNEPRGFSSREKLGVHFKIENPVQRIVYstRKTNIIFNFAEALWYLTGNNSLSYISYYNKRMPDYSMDGQTLTGTAYGKKLFHFGEQN---LNQWQNVKQELLNDADSKRAVIQIFDAHElnQNLDVSCTLGLQFLIRNNQLNMVAYMRANDAFRGIVSDIFSFTFIQEFMARELNLKVGKYYHSVGTMHIYEPDNQWVTHVLNeqTFISPKMPQGNNWAMVHEL----------------------
75 UniRef50_Q7Y427 dTMP (Thymidylate) synthase... 192 1e-47 1 50.3% 110:264 254:410 -------------------------------------------------------------------------------------------------------------DQLQNVIEQIKNNPTDRRIIIDSWNVQGTHNAVLGVCHPFVQFYVNEGKLSCMWFQRSVDSFLGLPFNVASYALLTHIIAKMCDLEVGELIFSGGDTHIYKNHFDQVMEQLSRVPFDKPTIEL-PEFKSLDEvtPKDFKIHNYQSHPAITAQMAV
76 UniRef50_C0ELR2 Putative uncharacterized pr... 192 1e-47 1 29.4% 2:253 21:294 -QQYVQLLKDLLDAPLVRNERTGTACHTIINPQSFTYTADDFPALTIRRSYWKSAVAEMLGYIRGYTSAKDFRELGTKTWDANANQndDMGLVYGAVGNSFTGLS------FTDIMRAIHARQDNRGLIWSFWNPDVFDKGCLRPCMYSHQFSIVNGTLYLTSTQRSCDVPLGLTFNMIQCWFLLYLVCTLTGLKFGHARHNIVNAHIYENQVDAVREMIAN-----PLLPRSIKFQHVDRMtvNDFELLGYD-----------
77 UniRef50_A7TUR1 Putative thymidylate syntha... 190 3e-47 1 23.9% 13:263 13:255 ------------KSGEKISPR-GMATHEVRDVHLLLTQPRARLFypARIVNPAFAVAETVWHLSGS-DAPWIFDYN-YRLRQFADDGVLLG-AYGPRMRNW----GGKVDQLARVVEILQADSDSRRALIQLYDPadAAGHKDVPCTLGFRFHLRAGRLHMATMMRGQDVWIGMPYDVFFYTVLHELVAGWLDAELGEFHLHIGSLHIYDEHIEQADALTSLSASEI--MPDLRTPWTGFSGLLDQVEARDVTGHPGWDA-MA-
78 UniRef50_P31654 Deoxyuridylate hydroxymethy... 181 2e-44 1 21.5% 2:262 11:271 -QLYMDILSTVIKEGDVLAPR-GKRIKEIRPVMIEFKNPIRRtfLKGRNINPFFQVAESLWILAGRSDVGFLLDYNKNM-GQFSDDGVFFNAPYGERLRFWNRSDANNfdQLRDVYEKIKADPDTRQAVAVIYNpnINNDTKDRPCNLLLSFKLRNGKLDLSVYNRSNDLHWgfGANLCQFSTILEAMATWLGVEVGSYYQITDSLHVY---LDDYGAKITEDIQKVYGVNLETDEAPV----VEDFE-ELLDPNPRMSYTM--
79 UniRef50_B5S769 Putative thymidylate syntha... 180 3e-44 1 25.5% 12:231 5:226 -----------LQNGQRTAPR-GVATLELLPVAFTINDPRRrvSLPPRRWSIVYAIGELCWHLRGSSLVDEIAYYASRWRTIAGNATEVTGSNYGAKIFKGH---RGAPSQWSRVINQLRIDRDSRRAVLYFSGTGEdsDSKDIACAVSLQFLIRDGKLDAIANMRSNDAMLGLPYDVFLFSMLQEMAANSLGVDVGKYNHVAGSLHLYESDLLLAKDIIssEIRPMPRME---------------------------------
80 UniRef50_C4SF99 Deoxyuridylate hydroxymethy... 173 4e-42 1 21.6% 22:239 4:218 ---------------------RGQTQKEVLSTLTKinPRERFLVIPERKNNVFAQLAETIWVLAGRGDLEFLQHYLPRSI-EFSDDNKTWRAAYGPRLRNW----MGKTDQVSCVISRLQEDPNTKRAVMSLFDpsDYSDTKDVPCNNWLQFIQRDNILYLHVTVRANDAIWGfgINFFEWSVLHEIVATTLGYQVGTLSWYVGTFHIYSRHYNTSRDLLRIKNPKSP-YECGIEPTSI-------------------------
81 UniRef50_Q2T5Q0 Deoxyuridylate hydroxymethy... 173 5e-42 1 18.1% 2:260 9:265 -ELYLATLSDVCGAYEFRSAPRGHAEREIIGYGARIDDPRARFCRRAakQNVVFNYAEALWYLSGRNDLEFIEHYAPSMARYSPDGKHLPGTGYGARLMHYGA---RALDQIERALDIlrDDAESKRVVLQIFSADEdrRNIDVSCTLGLQLLLREGRLHMVAFMRANDAYVGLLNDVFSFTFLQEYVATRLDCEIGAYSHHVGSIHVYDDNLPRALALLDDSDAQipRMPAGTSPATIARVL---------EHEGRIRA----
82 UniRef50_B5UXF4 Thymidylate synthase n=1 Ta... 173 6e-42 1 19.6% 2:246 11:251 -EIYLNLLVEAITKKVNITDSRNGPVKDLGPAYFEITNEdrVPILQERALNPFFALTEFSWIITGSNRLTPLN-NFINDFDRFSDDGFTLNGAYGHRLRELH-----GLDQLEKSIRILQEEKSTRRVVLTMWHIDDlsNSRDIPCNISIMLKIRNNLLDMTVINRSNDLFLGVPYNVVVFYLLQCYIAKKIGCKVGVQRHFTDSLHLYSQHFEKVQSIIQNNNLERIKY-MYEKFEKIDLSTYID------------------
83 UniRef50_B2ZYD3 Deoxyuridylate hydroxymethy... 171 2e-41 1 19.7% 8:236 59:301 -------LETICTVGLKTDSRNGPVIRFPTPVTSVYTHPRQRVSfaVRDANPFLHLMEALWMLAGRNDVEFASYYAKQML-EYTDDGSTLNGAYGFRWRQ-----HFGYDQLNAIIDELKKNPASRRCVLQMWDASrnQGSKDLPCNTSVMFDAQLGKLNMTVTNRSNDMIWgyGANVVHFSMLHEYVAEKCGLPLGHYYQVSNNLHVYL-EFDITKRFIVDTTYgqPVLRKGPDV----------------------------
84 UniRef50_Q46E28 Putative thymidylate syntha... 170 5e-41 1 20.1% 3:221 19:214 --AWYRGLNIIRNHGQVITDERGSQIREFMDLMIIIEDP-----------YTDRIPHETAW------NEERLEEYAKQLI--SGENTQDFEYTYGQRLRNW----HGKVDQIDYVIEKLQQNPTSRRAIAVTWIPPVDTKVNEVPCMMLDDFKIRDGKIHLTTLFRSHDFGGAYPANLYGLSKLLEYVADKVGTKPGTITTISISAHIYDHDWDMVENIVK-------------------------------------------
85 UniRef50_O26868 Putative thymidylate syntha... 170 5e-41 1 21.1% 4:221 14:221 ---WKKLVEKIMHDGREIRDERGSLTREVMNTVVTIKKpkSDDFYHIRRGSLLNIKVPEGYFWSG----EKLEKYSEQFL--SGDRKG-FVYTYGNRLRA-----HFGVDQLDEAIRRLKNCTESRRATMVTWDPPEDTASDEVPCMILVDFKIRDGRLFTTALWRSHDIYGAWFPNAVGLAYLADHVAAEVGVEVGHITIHSISAHIYEVNFKEAEEVIK-------------------------------------------
86 UniRef50_UPI00016AD9CB thymidylate synthase n=1 Ta... 169 1e-40 1 37.1% 106:264 22:193 ---------------------------------------------------------------------------------------------------------HKAIDQLRDCLDTIVRDPSSRRILFHGWNPAVLDEIALPACHLLYQfnVERREISLCLYIRSNDVGLGTPFNLAEGAALLTLVGRLTGYTPRWFTYFIGDAHIYENQLDMLKQQLEREPFESPRLEIAeePQWLERIEPSDFALVGYRHHEPLTAPMAV
87 UniRef50_B8GIB9 Thymidylate synthase, metha... 165 1e-39 1 19.0% 8:228 17:224 -------VKTVLEKGWVLGTEDGEATIECEELALQVENPTTEPMIST-----------------GSRFQRRFMEKYA--ADLLHGSDGIFEYDYHGRLFNWGDRLAaqVDQIAYIIRKLQEAPATRRALAITWNPVVDEQVKDCPCLQLVQCVIRDGALQMKVVFRSNDMLTASGANMFALVHLQLMIAEALGVRIGRYTHIALVPHVytRDMDDLKAFCNRGERFHP------------------------------------
88 UniRef50_Q2FCV1 Thymidylate synthase n=2 Ta... 164 2e-39 1 20.9% 11:211 19:221 ----------ILENGDHITASKGEN-FEVRNAVLTLENPRSRLSISETRSKLISCIGEFFWYLNGSDSLEFIEYyyRKYIEYQIDENKPALGAYGPRIF-------GAQNQFNKIIEVLKDKPTSRRAVISIYSKDDleDSRDIPCTCLLQFFIRNERLHLTATMRSNDAAIGLVHDIFSFTLIQelIRYIPNLQLGEYTHIVGSLHIYKK-----------------------------------------------------
89 UniRef50_Q5DN81 Thymidylate synthase n=3 Ta... 163 6e-39 1 20.6% 8:221 17:232 -------LAYLRESGLTRETRNGGAVVAPEPVTTVYEQPRERVLFSkrDANPFFHLFEALWMLAGRHDLAFVEKFAKNM-RSFSDDGETMWGAYGWRWRTFFD-----FDQLSWAVHRLRRLPNDRRVVVQMWAAGLDQERAdvPCNIAIHFRINdgQLDMTVWNRSNDIIWGAyaNVVHMSILQEYVASAVGVEVGRYWQVSDDYHAYSDLFNKMLPLMS-------------------------------------------
90 UniRef50_B7KFY9 Thymidylate synthase n=11 T... 162 2e-38 1 17.9% 2:236 201:420 -ETWIKILHKIRKTGTIRNTEYGEWQELIDIMAIVTDEPSDFYFPEPNYLSIE---------------RQNLQNYIEQMLSDLSSQEG-VEYTYGKRLRSW-----FKQDQIEQVIKKLTLDINSSRAVMSLWDVHDHEGNDNPPCLNHIWLRVVENELSLTATFRSNDMFSAWPANAMGLRALQQHILDNInlKMGPLITVSQSAHIYSDCWEYADRLIDEQYAKICQKRDFNDP----------------------------
91 UniRef50_B3FJL1 Putative uncharacterized pr... 161 2e-38 1 47.6% 74:264 187:457 -------------------------------------------------------------------------EYDQRIYRLLFDKegDLGAVYGKTWRdwVDYEARGFDFVVDvieqLRTNPDSRRIIVCAWAPQLVDEQALPPCHSFFQFWTRerAISCHLYQRSVDAFLGKPFNITFYSLLTHWLANQLNMVADEFVWTGGDCHIYSNHQEQTDLQLTREPKALPTIRFTPEakDIREIRPEDFEILNYEFHPHIAGKVAV
92 UniRef50_C5U4L9 Thymidylate synthase, metha... 159 9e-38 1 20.4% 2:222 10:208 -KAYEILVKEILEKGSEMITEDGQRCKELLNVFVKITNPKLKSiyPLGKNAIESYKKQLL---EGSQN--------------------NFTYNYYERIREYPSYDRkkNDQLSYVIEKLKNNSTSRRAVISLWQPFIDQKVKDVPCLQHIGFQLREDKLIMSVLFRSNDILLAFHSNALGLISLGELVAKSLEVELKEYNHFIYNAHIY---IDRDKDYLRR------------------------------------------
93 UniRef50_UPI0001C33797 thymidylate synthase n=3 Ta... 158 1e-37 1 18.4% 2:229 201:413 -ETWVRILHRIKTTGRVRPTEYGKWQELINIVAVVTDEPLDFYFPEPNYLPIR---------------REFINDYISQILDDSSQREG-IKYTYGQRLRSW-----FKKDQIQQVIDLLVSDINSSRAVMSLWDVNDYDNNDSPPCLNHIWIRTIDDELSLTATFRSNDMFSAWPSNAMGLRALqhIMREIQnlKIGPLVTVSQSAHIYNDCWEYADKIVDAEYETICR-----------------------------------
94 UniRef50_Q2NEY9 ThyA n=1 Tax=Methanosphaera... 158 2e-37 1 20.0% 2:221 12:207 -QAWLTCVKKIMQEGHEVTDERGSLTKELQNVILEITNPNDNTIPECSPWhlETYKKELL----------------------DPDNEQGFVYTYGNRLRQY-----FKIDQIDTCIEKLNNCPQSRRAIAITIDPIQDNKVDEIPCLQEIAFLIRDNQLYMTDFFRSNDCGGATFPNLFGIREVGYYVAKNTDTELVNMVHHAMSLHIYEHDWDKCREILR-------------------------------------------
95 UniRef50_C9DGK1 Deoxyuridylate hydroxymethy... 157 5e-37 1 19.6% 14:238 26:257 -------------TGQYKECRNGGST-FLRNVKFHITDPRNRNllNGRKSNIFQMVAETFWVMSGSGNIKEFLEFFLPRAPQYSDDGINWHGAYGPRMYAH--------NQLQSAIDLLIKDKDTRRAYVMIADPTLdhSPKDVPCNREIHINIIEDKLCMKVIQRSGDMLFGTGsnPFEFTFLQELLSEATGYALGDYQWDVTDAHYYKAFEDQVNDVLRSEQTFWPnkPLGTRFTS--------------------------
96 UniRef50_Q8MVZ9 Bifunctional dihydrofolate ... 156 7e-37 1 41.0% 4:147 149:314 ---YIDLIRRIRDQGEIRTDRTGVGIKCVFGNMMKFSLENgiPLLTIRKIFWKGVVEELLWMLRGKTHSRDLEEKGVNIWRANGSRegDLGPIYGWQWRhhTDYSGFGVDQIKDVISQLQNQPqnRRILFCSWNPKDLKQMALPPCH---------------------------------------------------------------------------------------------------------------------
97 UniRef50_Q1ZMM6 Thymidylate synthase n=3 Ta... 155 1e-36 1 34.9% 1:172 1:186 MKQYLALCQRIVDDGVWIEnrTGKRCLTVINADLTYDVANnfPLITTRKSFWKAAIAELLGYLRGYDNAAQFRAIGCNTWNANANdeDDMGRVYGVQGRRWQKSDGTPIDQLKKIVDDLTKGIDDRGEILTFYNPGEFDMGCLRPCMHTHTFSLLGDTLYLTSYQRSCDVPL--------------------------------------------------------------------------------------------
98 UniRef50_Q21ZJ9 Thymidylate synthase n=1 Ta... 155 2e-36 1 23.2% 27:216 37:228 --------------------------RELLHCALCIKDPRQRWVLSRRpiNPAFAIAEVIWILLGSDASNFLNFWNP-VLPKYAGSGGTYHGAYGARLR-----THFGLDQIERVYQILSANPESRQAVLQIWDseDLPLSddIPCNLVGMLKVRAQKLEWLQIMRSNDVFLGTPHNLVQFTSLQEIIAGWLGIGIGSFSLVTDSLHLYEHDYDRC------------------------------------------------
99 UniRef50_B3QQU8 Thymidylate synthase n=1 Ta... 154 2e-36 1 17.2% 11:242 20:279 ----------LIKEGVKRKTR-GKLCIELppFMFKITNPTARLvvPERRWNPILPFAESLWLATGKNDLEFIGHYLKNM-KNFSDDGEFLRGGYGPRLRKYNGINDDyvDQFGFICKSFEKDKFTRQAIINIGDpgNLKITKDFPCTRLLHFqpKANKLNLTVYMRSNDFVWGASanIFNFTFMLEYFSQILDLEIGEYYHIANNFHYYEEFEDLVQSISRTKTVEESKFEYSKSFHNLSEF----------------------
100 UniRef50_Q57931 Putative thymidylate syntha... 154 2e-36 1 17.5% 3:219 12:213 --AFNELIPKILKDGEVVETEFEERTKEIRNTIIEITNPK------LKKVPEKYPLGE-----------KAVEEYTKNLLYGSKNV---FSYDYHQRLFEYP-YADEKINQIDYIIEKLNQQKNSRRAVAITWNPKIddERGSVPCLQLVQFLIRNGKLYQTVIFRSNDALLAFVSNAIGLITLGEYIAKKVGVGYGTYTHHAISMHIydRDFDYIKKY---------------------------------------------
101 UniRef50_A3CSY2 Thymidylate synthase n=3 Ta... 154 3e-36 1 15.4% 8:228 17:224 -------VRTVLEKGWVLDTENDEATIECEELALEVESPESVPMASPASRFQ----------------QRFLDVYADNLLHGS---DAKFEYDYHRRLFDWGEqeDVHVDQIDYIARKLEQAANSRRAVAVTWNPVVDENLDDCPCLQLVQCLLRNGKLQMKVVFRSNDILSAAGSNMYALVRLQKMIADRLGVPCGRYTHIALVPHiyRRDLNDIEPFCKSGTEIRP------------------------------------
102 UniRef50_B2TJD1 Thymidylate synthase n=1 Ta... 152 1e-35 1 19.7% 2:235 12:246 -EVWEKAIKLLQKQEYSLSGRTGD-VFELLHTFISIEEPqkWIYNRIPPISIGYALAELVWIINGEEKSDIINMWNPSL-EKYAGRGDIYHGAYGKRIRS-----HFGFDQIEKAYEALQNTPESRQVVIQIYDTKVdpQDEDIPCNICSLLKVRNGKLEWSQIMRSNDVLLGMPYNFIQFTGLQEILAGWLELDLGSYNHYSDSLHLYARDINKIGIGQEVEIRNNDSLSLSRN-----------------------------
103 UniRef50_Q7Y590 Putative uncharacterized pr... 152 1e-35 1 18.3% 3:221 18:238 --AFKAVNREILENPEFVTDSRIGRCNEIGSMTVVVDTPSSFKMTDPRINRISYEYAEDFwmISGGTDAEEAFKAYPNVAKFISKPkaNFNTFYGPRIAA----------QLPALLKELKEKPNSRRVVFQILESSdsDETLEYPCTDSVTYYIRDGKLYTHCHMRSQNCAVVMQLDFYLQGKLLHYIANECGVEVGDYTHTMVSAHVFERDFDYVKGFLD-------------------------------------------
104 UniRef50_UPI00016AEAE5 thymidylate synthase n=1 Ta... 149 1e-34 1 21.5% 8:221 34:249 -------IHNIVKEGRKIKSRAGDA---MQAYGVNYILKDPRSRVHsrNGAKRYLCRELLAYFSGSLKAENGLANASKFWMTLTDKDGNVNSNYGYY--VFYEPVEKYGNQYNWIVSMLKSNQDSRRAIININQNYHKSDTKDFPCTIGMQFFIRENHLFCETISRSTDVITGLPYDMGFFSFVHELVHSDldLQLGSTIMKTTFTQIYDNAMEKAKDAMN-------------------------------------------
105 UniRef50_O28232 Thymidylate synthase, putat... 148 2e-34 1 18.3% 3:220 252:465 --AWHSALETIYTNGKKKRTEWGDIFEGQKESLFVHRLFLEVEKPEENKLHDKAPFTE-------KYGIEYAHDYIMHAAKLDGEVRRSieYTYAERAR-YCDRDDVKVDQLYKVIEKLKEDSCRRDCYVGISRPWDL-LSDEPPCLRGYQFSKYGDELLGTFYMRSNDAYGAMHANMYAFALLTKYVAELTGFKSYRYNHFALDAHIYAEFFDAVREIL--------------------------------------------
106 UniRef50_C8XUG3 Putative thymidylate syntha... 147 3e-34 1 20.2% 5:217 13:235 ----KQAVLAIREYGIESDPGNadGTRFLDGVTITvdIRDRWLSVEGRNSSAIAAIGETFWVLSGRNDIKFLSRVLPRAAN-FSDDGVTWRAAYGPRLYAHG--------QLDSVINRLRKNPNTRQAYLTIYDPALDSdtKDMVCNLALLFAIVDGRLNLTVINRSQDVLWGMSsnFIEFSILQEVIAQVLDVDVGQYKLFSNNLHYYNNEVSQKQ-----------------------------------------------
107 UniRef50_P18029 Deoxycytidylate 5-hydroxyme... 145 1e-33 1 22.1% 12:237 19:246 -----------LKEKDFVVDKTGVKTIEIIGASFVADEPFIFGAL-----NDEYIQRELEWYKSKSLFVKDIPGETPKIWQQVASSKGEINSNYG--WAIWSEDNYAQYDM---CLAELGQNPDSRRGIMIYTRPsnKDGMSDFMCTNTVQYLIRDKKINAVVNMRSNDVVFGFRNDYAWQKYVLDKLVSDLnyKAGSIIWNVGSLHVYSRHFYLVDHWWNTGETHIVKKDYNGEWK---------------------------
108 UniRef50_UPI0001C42129 thymidylate synthase ThyA n... 144 2e-33 1 18.2% 2:221 6:229 -QCYLEFVNKILKEGKETYKDSDHHLKEYLGNYYYIDDPLDLKFRAkqHMTPELMLEE---IKKGRYDIdpIKGDALYEYVKSFEIRDDQGFVYTYPNRIL---EHFGVDQFEVMKERILTATGSNRAVAVTYDPKLDHDREDIPCLQFVQMLVRDGELTIHVIFRSNDIFGAFYSNMFFICYMGIKMKEEVNKEigGIHYHSTSGHIYNNDMRAARKLIS-------------------------------------------
109 UniRef50_Q52PP0 Putative thymidylate syntha... 143 4e-33 1 19.6% 6:235 13:240 -----DLMLRTFTQGFVSKPR-GMEIRELLNAQVTVQTFVPFQCWPDRKYDIGYFKKEMRWKL-GASKFDDSIKQHAKMWESVQNPDGTFNSNYGQFWFGQQMG-------VMKVVMELIRDQDSRRAIimLTDDHLSPETVDTVCTEAVSFHIRHNTLYTSVHMRSSDQIFGLGTDIPTFSVLTHLvaNYPSLQVGSMTITAASSHIYERHYRMVDKILDneDIPDSEIVILPQ-----------------------------
110 UniRef50_A5UP11 Predicted thymidylate synth... 142 8e-33 1 17.4% 2:220 6:228 -QCYLDFVKKILNQGKETYKDSNHHLKESLGNFYVIDDPLNLKFVAkqHMTTDMMLNE---IKSGKYDIepIKSDALYEYVKSFENSDDQGFVYTYPNRILAHFD---VDQFEVMKKRMLHAIGSNRAVAVTYDPKLDQDREDIPCLQFLQCIVRNNELTIHCLFRSNDIFGAFYSNMFFITYIGIKMKEELNKElgGIHYHSTSGHIYSNDMKAAKKLI--------------------------------------------
111 UniRef50_B1ZRC5 Thymidylate synthase-like p... 142 9e-33 1 13.4% 32:263 49:289 -------------------------------MNLTVLDPLAEPMIHKAFPGGIEELREYVMEVSGAKdvKNMNDPKDTRWEyyHGRLAAYGTWQESRDGQPVRVGGFNVNQIEAVIAKLVKQPFTRQAQMITWMPNIDLECYDPPCLQSLWYRLMEDdlNCNVRFRSNDAWGASFMNMFGFViiAAEIARRTgiKLGRLNWQADSYHIYGKDIAEAKARL------FDRIPRGPLADRTYEFSDEGIQEMYNDAEAAVRAKIA-
112 UniRef50_A1RYR8 Thymidylate synthase-like p... 137 4e-31 1 16.8% 2:227 171:377 -RAWVKLVDAVMTWGFVKGSEYGERQRQLLGAVVVLDASQPLD----ERVY-RYFPRE------------DFERQAKSILEG---EEGAV-YSYGDRLRRHREAG----DQVRRIVERLASSPDTRRAIALTWDFATDTNSQDPPCLVAVQGDLSGDTYNQVAFFRSHDAYAAWPLNAYGLLALMRRVAGELsvKPGWLVVYSSSLHVYEHDWGRALRLVQENAAEA-------------------------------------
113 UniRef50_C9KVG6 Thymidylate synthase n=14 T... 136 6e-31 1 23.5% 1:221 22:222 MNKYYQTLDKILQTGKIQTNRKG-RIKYLLNERLMLTPADLLDIFESHGIARKKLKEELKLFMQGVRDVEKYKEAGITWWDYCGHTLVNSYPTYFEKL-----------PPLITRINREKRNSKNYVLFLGETGV----ESNQAPCLSLVQFQIDEGELVLSAYQRSSDANLGLPADIYH----LYLMARQVELPLKSITLDLGNVHIYENNIDRTLELLS-------------------------------------------
114 UniRef50_Q8TVL9 Putative thymidylate syntha... 133 5e-30 1 15.8% 2:216 17:208 -QVWRQAVTGIKVHGEKVERERG-PVKEVRGLIAHLEppESFDIP----------------------DDYPLDEHSVRAYEDQLLDPELRgyTYGHRLRRY-----FGLDQVTKIVERLSESNNTRRAIAVTWDPRRDLDEEEVPCLTALQLQSDGggLELHAFYRSWDVGKALVANMIALRRLQEHVAERAGLEPTTLTVYAANAHVYEEDLPDL------------------------------------------------
115 UniRef50_A2E1C8 Putative uncharacterized pr... 130 7e-29 1 16.5% 4:258 196:422 ---WKKVIHKIIEFGEFKK-RNSIGESYYELIDFTYVLeeNRKYETIETTGEVPITDEFL----------------KHYITEIISDKVPPGLSYTYGNRIARH--------LDATVKKLQTDPVTRQAHISLWLDQDVSSPN-PPCLTDIDFNLQKNRLFMTCHFRSHDAFAALRSNMYGLVKLQEkiSQLPGVREGPLVLMANSSHIYERDIDTIKRSIVFGP------ECNADKRGYFTVAVenIVICHYDYENKL------
116 UniRef50_D2BHQ5 Thymidylate synthase n=5 Ta... 129 1e-28 1 18.5% 2:217 13:209 -EAWFLCLRQVLTDGYEYTIERGSYskELDMITVHIKNPGNRPLIPDVPPGVPAP-----------STMEYIDNYLPYLMTAHRAEGE--QYTYGQYLEA----------QIAKVIKMYKEtfNTNQAFMTVGNPETLDL-EDPPCLRSIDTRVRYGKLHFIIYFRSWDLWAGFPSNLAAIQMLKEYMAAEIGVEDGEIIAMSKGMHIYDYAWDIAK-----------------------------------------------
117 UniRef50_D1YXV9 Thymidylate synthase n=2 Ta... 121 2e-26 1 15.9% 2:221 11:211 -EAWYWAIKEIYTNGQLVETEYGIKAKCINGMLLEVRNP--VQVWHKKDPF---CTKE---------RVEFYKKQFKR------ESAGRHGFEYTYIDRL---VNYEGFDQLKWMGEQLQNKreSKRIQAITWMPKIDckKEDQPCFQRIwfPHKNNKLDVHIHYRSWDMFKAFEANLMAFQELveLI-GPTDFMLGTLRCFGDNVHIYEDDFQAAEEVLK-------------------------------------------
118 UniRef50_Q8MW00 Bifunctional dihydrofolate ... 119 8e-26 1 48.0% 4:103 148:259 ---YLDLIRRVLADGFERDDRTGVGTFSLFGEKLEFDLGDGFPLLTTKRVFWRGVAEELLWFVSGSTNANELAAKGIRIWDGNSSRegDLGPVYGFQWSHFGA-----------------------------------------------------------------------------------------------------------------------------------------------------------------
119 UniRef50_Q8MVZ8 Bifunctional dihydrofolate ... 119 9e-26 1 52.0% 2:103 146:260 -KQYLDLVDRIITSGTQRGDRTGTGTLSIFGTQMRFSPRDdlPLLTTKKVFWRGVAEEMLWFMKGCTDARVLSAKKIHIWDDNAseEGDLGPVYGFQWRHFGA-----------------------------------------------------------------------------------------------------------------------------------------------------------------
120 UniRef50_Q8MVZ6 Bifunctional dihydrofolate ... 118 1e-25 1 46.1% 2:103 141:255 -QQYLDLVDDIIKNGFTKGDRTGVGTISKFGAQMRFSLRDGvpLLTTKRVFWKGVAEELFWFIKGCTNGKDLKDKGVHIWDGNGTreDDLGPIYGLQWSHFGA-----------------------------------------------------------------------------------------------------------------------------------------------------------------
121 UniRef50_Q2FKU7 Thymidylate synthase-like n... 114 3e-24 1 21.2% 2:223 69:271 -EQYQASLYTI----TPRRD-DGTDAVYTYGNRLRDYPKAEVGIVSKHGGAVKKAIDALF------RKLGYVPADACgiWKGDGR--------YG------------GIDQieSIINRLIQNPESRRAISITWFPVQDITADEPPCLQLVQCVikNNHLNLICVFRSNDMLSAWGQNAYGLAHLQKFICEQINLkqGWLETISISAHMYF-HRDQLELNLFLE-----------------------------------------
122 UniRef50_A5KRW4 Thymidylate synthase-like p... 113 9e-24 1 21.5% 69:217 58:202 --------------------------------------------------------------------QEDLDIINRYIYTGENEDKVIHDWTKLYYHRAFDEPN----SQIEFLISKL--DPQSPkaQISMWDKNIDQDQKVSPCTQIIWARIKHGKLELHVHAHSSDVYKKLLMNILEFVSLQHYIAERVGVPVGKYYHFLDSGHLHQKDIKAIE-----------------------------------------------
123 UniRef50_B8KML0 Putative thymidylate syntha... 111 2e-23 1 23.0% 86:224 41:172 -------------------------------------------------------------------------------------EMEDRPFTYGQLI-----YDMNGIDQFDWMVGRLRNKSETKSAAISLLVPG-LNQANL-PCLCVVDSKIRNGKLNLQFFFRSQNVFGRQYANLVAIARLQEKLAASVGCDIGILKGYIASAHIYEYDLEEARSLVEGRP----------------------------------------
124 UniRef50_Q8MVZ5 Bifunctional dihydrofolate ... 111 2e-23 1 54.5% 3:103 198:311 --QYLDLVQRVVSTGVSRGDRTGTGTLSIFGAMMRFDLSSgfPLLTTKKTFLRGIAEELFWFLKGDTSQTRLAAKDVHIWDANATreGDLGPVYGCQWSHFGA-----------------------------------------------------------------------------------------------------------------------------------------------------------------
125 UniRef50_A9A0S4 Thymidylate synthase-like p... 109 1e-22 1 24.5% 79:217 121:257 ------------------------------------------------------------------------------WWHENASEIVDRREPDGKI--VFEEDGRLYINQIEWVIDTYKrgARNNQMVLQVAEPSDLALL-DPPCLRSIDTRIQDDQLIFFVYFRSWDLWGGLPANLAGIQNLKEYMAGEIGVADGPMIVESKGLHLYGYAEDLAK-----------------------------------------------
126 UniRef50_Q82RC3 Putative uncharacterized pr... 107 4e-22 1 18.4% 2:208 18:248 -QAWVAACNKLDRK--DNPDRTGLHTVVRIA-----DPTSDDPVFRAELDRLRTARG--LWPlaRSADPDDLAERYRRMYPVIKRYPGNHRGTYFGRLVFYPAASKTGIDQLSTVISRLRTQAAGTKiiAAATDQEedNSYIGFPCLSHISLQlrDRRVHAAALYRSHFMFERAYGNYLGLGRLLAYIAQQAELACGTLTVMAGHARL--------------------------------------------------------
127 UniRef50_D2B6A6 Putative uncharacterized pr... 106 1e-21 1 18.7% 2:226 12:208 -ETWIWLMRHVRTNGRAAEDDRGP----IIEAQAV--------LFEIAGLGWDDPILESY----GDSGKIPL------YAGKFSECAipFKYSYGGRLRRL-----LGVDQLHWVADVLRAKPYTKSGWISLTVPGESPDA--VPCLTSLAFRLRDGRLVMTAAFRSQNVFTS-YLNYVPLRSIQNEVAGDLGVGCGSMRVFVDVPHIYVADAAAVGEILRLSERD--------------------------------------
128 UniRef50_C0GRD7 Thymidylate synthase-like p... 104 3e-21 1 19.1% 91:226 99:224 ------------------------------------------------------------------------------------------DYTYGERIYQ----------QVLYWIGKFNQTWATNQAILQVGRPED-HLLNDPPCLRHIDMRIRDGRLIFYPYFRSWDLWGGFPANLAGIAVLQKYMADSigVSPGPILASSKGLHIYGYAEELARIRTCRKDAP--------------------------------------
129 UniRef50_B5UXF2 Putative uncharacterized pr... 99 1e-19 1 9.3% 3:206 13:223 --AWKKAIEHLIQNGKDDYN----LIVEIENPTvkVRDQFNQVLFNMNDQRIETVANTIfgMNNKSENRFDFYKRFQRVYPTLRKVMENNKGTYFGRLVEWNYGRGETFNQLDHTILKLAREKNNGRGimSIYDPNLDHNNQmfPCMSFISLKIRKDFIDLTAIYRNQYFVQKAYGNYLGLGRLLEFISKESGYKMGKLTCIATHA----------------------------------------------------------
130 UniRef50_Q13ZS5 Putative uncharacterized pr... 97 5e-19 1 14.4% 27:206 45:232 --------------------------REIEVPSIRTRLDTELVAFSENKCNtnTIFPMSMWNPHLDDDADALFRRYERAWPGIKKCPANKYGVYFRRLTAypNGVQKSVNQLESIIDSYQRGNHRKSAlvSVFDPTRDHTnkGFPCLQQVSFtlENGLLSVTGFYATQYQFEKAYGNYLGLYWLGKFVAAQLNMTLSQVVCSAAVL----------------------------------------------------------
131 UniRef50_A5ETP5 Putative uncharacterized pr... 95 3e-18 1 13.8% 53:204 70:226 ----------------------------------------------------FTIFPQRLWEMSRGDRSRLFILYRATFPrqAMNRKANGRGLYFERMVMYGRGPHDG-NQLEWILSQFSSRTGVRRSMLQafDPARDHVASafPCLQQVSFEPTAAGLVTNAFYATQQIFDKAYGNYLGLAQLGAFMAREMGMPLARLNVMVG------------------------------------------------------------
132 UniRef50_A5VDP1 Putative uncharacterized pr... 91 4e-17 1 13.0% 71:208 87:232 ----------------------------------------------------------------------FFDRFRDNVLPKVRNKGDRWSGYYFERMMQLPQLKGEPINQLTDIIRRLKDSSIsnKFELSVFDPARD--VDDSpcLSFASFKpsNRRLALTAMYRNHYYIEKLLGNLIGLGRLMAFVAAEAGIAPGPLTILSTHATI--------------------------------------------------------
133 UniRef50_C2KJS6 Possible thymidylate syntha... 84 4e-15 1 22.0% 161:242 1:85 ----------------------------------------------------------------------------------------------------------------------------------------------------------------MVVYMRANDAFRGMVSDIFSFTFIQEFMARELNLKVGKYYHSMGTMHIYEPDNQWVKHVLNeqTFISPKMPQGNNWAMVHEL----------------------
134 UniRef50_C8SR56 Putative uncharacterized pr... 83 7e-15 1 17.4% 63:206 76:232 --------------------------------------------------------------LDRGDGIDALTKRYMQVYERRMHRQGEWGR-YFQRMVAWPNGGGRgvNQLSANIETLRakFFGNVTEIALFDPadLRKKMNRQCLSFIELKprQgrLSMMAVYRNHYYVQRTLGNLIGLGRLLQFIANETGFEIGTLTIQSTHA----------------------------------------------------------
135 UniRef50_A1KLI7 Putative uncharacterized pr... 81 4e-14 1 18.9% 68:210 68:225 -------------------------------------------------------------------NSDQLKAMLDFMFNTDTMEDIDVVKSFSRGAKSYHRRIKEGR-MIEFVIERLSLIPESKKAVVVFPTYEDyhRDDYLPCLVSIQFRLldGkfHTTFYSRSMDAWQKGHGNLLSIAKLSDWVRENVsiMLGPLDGMICDVHIYK------------------------------------------------------
136 UniRef50_B9PCT2 Predicted protein (Fragment... 77 7e-13 1 66.7% 1:57 1:57 MKQYLDFMRHVYEHGTEKSDRTGTGTRSVFGYQMRFDLNEGFPVVTTKKLHLKSIIH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
137 UniRef50_B0YLI9 Thymidylate synthase-like p... 74 5e-12 1 23.8% 174:253 5:84 -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------APLTIAKYSLLTYMIAYVCNLMPYSITYTMGVSYINKYELDILQSYTKMKQYKFPRLIVEHYVKDIYSFNLGNFLLYDYQ-----------
138 UniRef50_UPI0001742C7A thymidylate synthase n=1 Ta... 72 2e-11 1 39.7% 202:264 1:61 ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TIIDAHIYENHIEGLKEQLTRKPLKLAKIKIADKP--FNELTFEDITLEDYESYPAIKFEVAV
139 UniRef50_C7JA78 Os12g0446900 protein (Fragm... 70 7e-11 1 65.1% 152:194 33:75 -------------------------------------------------------------------------------------------------------------------------------------------------------FYVENGELSCQMYQRSADMGLGVPFNIASYSLLTCMIAQVCGM----------------------------------------------------------------------
140 UniRef50_Q5D6W4 Thymidylate synthase-like p... 61 2e-08 1 42.9% 1:56 1:56 MDNYKDLLREVIITGTDSVDRTGVGTVSIWGAMLKFNLQEGFPATTCKGLAWKAFL----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
141 UniRef50_B0YLJ0 Thymidylate synthase n=1 Ta... 56 9e-07 1 25.3% 2:76 21:91 -NKYPTLVNNIIEHGISTEKK-----ISVFGAQLEYDLRNkfPLFISKRYDWAYVIEELLWCIRGETDRKNINSRT--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
consensus/100% ........................................................................................................................................................................................................................................................................
consensus/90% ..............................................................................................h................h...h..h.....tt...h..............sC.....h...tt.h.h....Rs..h..t...shh.h..h..hht...sh..t.h.h......h........................................................
consensus/80% ...........................h....h.hp....h.....t.......h.t.........t...h.....thh....tt...ht..Ys.thh..........sQht.hlp.lttp..s+phhh.hhps......t..PCh..h.h.l.tstL.h.hh.RS.Dhhhuh..shhththl..hhAt.hsht.u.hhh.htshHlY..th..h...h............................................
consensus/70% ..a.t.httlhppG....stps..hhthhs..hphp..pth.hhs.pth.hh.hhtEhhhhhtttpp.p.l.t.t.phhpt..pptsphs.sYG.phtth.......hsQlt.llpplppsspsRRhlhphasstt.tpht..PChhhhpa.ltsspLph.hh.RSsDhhhuhshNhhthshL.thlAp.hshp.GphhhhhsshHlYtpphp.hp..hp...........................................
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