BLASTP 2.2.22 [Sep-27-2009]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.


Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.


Reference for composition-based statistics starting in round 2:
Schaffer, Alejandro A., L. Aravind, Thomas L. Madden,
Sergei Shavirin, John L. Spouge, Yuri I. Wolf,  
Eugene V. Koonin, and Stephen F. Altschul (2001), 
"Improving the accuracy of PSI-BLAST protein database searches with 
composition-based statistics and other refinements",  Nucleic Acids Res. 29:2994-3005.

Query= batch____
         (418 letters)

Database: uniref50.fasta 
           3,077,464 sequences; 1,040,396,356 total letters

Searching..................................................done


Results from round 1


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

UniRef50_B5YZU3 Putative ion-transport protein yfeO n=97 Tax=Ent...   809   0.0  
UniRef50_A4WD06 Cl-channel, voltage-gated family protein n=5 Tax...   572   e-162
UniRef50_B5XVU7 Chloride transporter, chloride channel (ClC) fam...   548   e-154
UniRef50_Q8DIV5 Tlr1476 protein n=1 Tax=Thermosynechococcus elon...   107   1e-21
UniRef50_B0CCE6 Cl-channel, voltage gated n=3 Tax=Cyanobacteria ...    80   1e-13
UniRef50_Q3MBC4 Cl-channel, voltage gated n=7 Tax=Bacteria RepID...    75   5e-12
UniRef50_Q0TTC6 Voltage-gated chloride channel family protein n=...    65   3e-09
UniRef50_C8XF05 Chloride channel core n=5 Tax=Actinomycetales Re...    57   1e-06
UniRef50_C6JBA2 Voltage-gated chloride channel family protein n=...    54   1e-05
UniRef50_O54193 Putative membrane protein n=3 Tax=Streptomyces R...    54   1e-05
UniRef50_C1DC80 Probable voltage-gated chloride channel family p...    52   5e-05
UniRef50_A3YZH8 Chloride channel-like protein n=1 Tax=Synechococ...    52   5e-05
UniRef50_B8C337 Chloride channel protein (Fragment) n=1 Tax=Thal...    50   2e-04
UniRef50_C3ATP4 Voltage-gated chloride channel n=9 Tax=Bacillus ...    49   3e-04
UniRef50_B7G8L3 Predicted protein n=1 Tax=Phaeodactylum tricornu...    49   5e-04
UniRef50_D0R1Y7 Putative uncharacterized protein n=9 Tax=Lactoba...    48   6e-04
UniRef50_C2KWR2 Chloride carrier/channel (ClC) family transporte...    47   0.001
UniRef50_B0G1X5 Putative uncharacterized protein n=1 Tax=Dorea f...    46   0.002
UniRef50_A5GMC1 Uncharacterized conserved membrane protein n=3 T...    46   0.002
UniRef50_C4Z1M2 Chloride channel protein, CIC family n=1 Tax=Eub...    45   0.004
UniRef50_B1LX30 Chloride channel core n=18 Tax=Alphaproteobacter...    45   0.004
UniRef50_C4KYZ9 Chloride channel core n=1 Tax=Exiguobacterium sp...    45   0.004
UniRef50_Q38V51 Hypothetical integral membrane protein n=1 Tax=L...    45   0.005
UniRef50_C0W1S0 H(+)/Cl(-) exchange transporter n=1 Tax=Actinomy...    45   0.006
UniRef50_B5YBN2 SycA n=1 Tax=Dictyoglomus thermophilum H-6-12 Re...    44   0.016
UniRef50_A5EFE0 CLC-type chloride channel protein n=3 Tax=Bradyr...    44   0.017
UniRef50_B5ZGR7 Chloride channel core n=11 Tax=Bacteria RepID=B5...    44   0.017
UniRef50_B7FTG7 Predicted protein n=2 Tax=cellular organisms Rep...    43   0.018
UniRef50_C0YIY4 Chloride carrier/channel (ClC) family transporte...    43   0.027
UniRef50_A0NVL9 Cl-channel, voltage gated n=2 Tax=Alphaproteobac...    43   0.027
UniRef50_B7G9G8 Predicted protein n=1 Tax=Phaeodactylum tricornu...    42   0.055
UniRef50_B8DDG6 Membrane protein, putative n=19 Tax=Listeria mon...    41   0.065

>UniRef50_B5YZU3 Putative ion-transport protein yfeO n=97 Tax=Enterobacteriaceae
           RepID=YFEO_ECO5E
          Length = 418

 Score =  809 bits (2090), Expect = 0.0,   Method: Compositional matrix adjust.
 Identities = 418/418 (100%), Positives = 418/418 (100%)

Query: 1   MLHPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWII 60
           MLHPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWII
Sbjct: 1   MLHPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWII 60

Query: 61  GVLTLTGIAVGLVIRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPE 120
           GVLTLTGIAVGLVIRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPE
Sbjct: 61  GVLTLTGIAVGLVIRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPE 120

Query: 121 HPIMTVNIALAVAIGARLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEV 180
           HPIMTVNIALAVAIGARLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEV
Sbjct: 121 HPIMTVNIALAVAIGARLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEV 180

Query: 181 PLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVA 240
           PLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVA
Sbjct: 181 PLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVA 240

Query: 241 VWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSD 300
           VWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSD
Sbjct: 241 VWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSD 300

Query: 301 YFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIV 360
           YFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIV
Sbjct: 301 YFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIV 360

Query: 361 LVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNRPKQQPPHDNV 418
           LVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNRPKQQPPHDNV
Sbjct: 361 LVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNRPKQQPPHDNV 418


>UniRef50_A4WD06 Cl-channel, voltage-gated family protein n=5 Tax=Bacteria
           RepID=A4WD06_ENT38
          Length = 411

 Score =  572 bits (1475), Expect = e-162,   Method: Compositional matrix adjust.
 Identities = 329/411 (80%), Positives = 366/411 (89%)

Query: 1   MLHPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWII 60
           MLHPRA+TMLLL+ PA+ IGIASSL+LIVVMK+ASVLQ  LW  LPG LGI   SP WII
Sbjct: 1   MLHPRAKTMLLLATPALIIGIASSLVLIVVMKVASVLQAFLWTALPGKLGIDFASPTWII 60

Query: 61  GVLTLTGIAVGLVIRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPE 120
            +LTLTGI VGLVIRFS GHAGPDPA EPLI APV P+ALPGL++ALI+GLAGGVSLGPE
Sbjct: 61  LMLTLTGITVGLVIRFSPGHAGPDPALEPLISAPVNPAALPGLLLALIIGLAGGVSLGPE 120

Query: 121 HPIMTVNIALAVAIGARLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEV 180
           HPIM VNIALAV +G+R+ PRV  ++WTILASAGTIGALFGTPVAAALIFSQTL+G ++V
Sbjct: 121 HPIMAVNIALAVYLGSRIFPRVGALDWTILASAGTIGALFGTPVAAALIFSQTLSGDNDV 180

Query: 181 PLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVA 240
           PLWDRLFAPLMAAAAGALTT LF+HPHFSLPI HYGQM++ DI SGAIVAAIAIA GMVA
Sbjct: 181 PLWDRLFAPLMAAAAGALTTSLFYHPHFSLPIPHYGQMQLADIFSGAIVAAIAIALGMVA 240

Query: 241 VWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSD 300
           VWCLPRLH +MH++K+ VL+LG GGF+LGILG IGGPV+LFKGLDEMQQM  +Q FS SD
Sbjct: 241 VWCLPRLHRLMHKLKHSVLILGAGGFLLGILGAIGGPVTLFKGLDEMQQMAFSQVFSVSD 300

Query: 301 YFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIV 360
           YFL AVIKLAA+VVAAA GFRGGRIFPAVF+GVALGLMLHEHV AVPAAIT+SC+ILG+V
Sbjct: 301 YFLFAVIKLAAVVVAAACGFRGGRIFPAVFIGVALGLMLHEHVDAVPAAITISCSILGLV 360

Query: 361 LVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNRPKQ 411
           LVVTRD WLSLFMAAVVVP+T LLPLLCIVMLPAWLLLAGKPM+M  R  +
Sbjct: 361 LVVTRDAWLSLFMAAVVVPDTNLLPLLCIVMLPAWLLLAGKPMLMAWRQNK 411


>UniRef50_B5XVU7 Chloride transporter, chloride channel (ClC) family n=18
           Tax=Bacteria RepID=B5XVU7_KLEP3
          Length = 411

 Score =  548 bits (1413), Expect = e-154,   Method: Compositional matrix adjust.
 Identities = 316/408 (77%), Positives = 364/408 (89%)

Query: 1   MLHPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWII 60
           MLHPRARTML+LS+PA+ IGIA SLILI  MK+A++LQ +LW  LP  LGI+ DSPLWII
Sbjct: 1   MLHPRARTMLILSVPAILIGIACSLILIGAMKVAALLQRVLWSNLPTQLGISADSPLWII 60

Query: 61  GVLTLTGIAVGLVIRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPE 120
            +LT TGIAVGLV+R+S GHAGPDPA E LIGAP+   ALPGL+ ALILGLAGGVSLGPE
Sbjct: 61  AMLTATGIAVGLVVRYSPGHAGPDPATESLIGAPIATGALPGLLAALILGLAGGVSLGPE 120

Query: 121 HPIMTVNIALAVAIGARLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEV 180
           HPIM VNIALAVA+G+RL PRV+ ++WTILA++GTIGALFGTPVAAALIFSQTLN S+E 
Sbjct: 121 HPIMVVNIALAVAVGSRLFPRVSSLDWTILAASGTIGALFGTPVAAALIFSQTLNSSNES 180

Query: 181 PLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVA 240
           PLWDRLFAPL+AAAAGALTTGLFFHPHF+LPI HYGQM   DI+SG IVA IAIA GMVA
Sbjct: 181 PLWDRLFAPLLAAAAGALTTGLFFHPHFTLPIPHYGQMHFVDIISGMIVALIAIAVGMVA 240

Query: 241 VWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSD 300
           VWCLPRLHA+MH++++P+L LGIGG +LGILG IGGP++LFKGLDEMQQ+  +Q  + +D
Sbjct: 241 VWCLPRLHALMHRLRHPILTLGIGGLLLGILGTIGGPLTLFKGLDEMQQLAFSQTLTAAD 300

Query: 301 YFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIV 360
           + L+A++KLAALV+A+ASGFRGGRIFPAVFVGVALGLMLH HV AVPAAITVSCAILG+V
Sbjct: 301 FLLIALVKLAALVLASASGFRGGRIFPAVFVGVALGLMLHAHVDAVPAAITVSCAILGMV 360

Query: 361 LVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNR 408
           LVVTRDGWLSLFMAAVVVP+TTLLPLLCIVMLPAWLLLAG+P+M+  R
Sbjct: 361 LVVTRDGWLSLFMAAVVVPDTTLLPLLCIVMLPAWLLLAGRPLMIAKR 408


>UniRef50_Q8DIV5 Tlr1476 protein n=1 Tax=Thermosynechococcus elongatus BP-1
           RepID=Q8DIV5_THEEB
          Length = 420

 Score =  107 bits (266), Expect = 1e-21,   Method: Compositional matrix adjust.
 Identities = 109/389 (28%), Positives = 188/389 (48%), Gaps = 21/389 (5%)

Query: 40  LLWQRLPGTLGIAQDSPLW--IIGVLTLTGIAVGLVIRF--SQGHAGPDPACEPLIGAPV 95
           LLW   P  + IA    L+  I  V    G+ VGL ++F  ++G    D   E   G  +
Sbjct: 39  LLWGTDPSQVSIATWEHLYPYIPLVTAFGGLLVGLSVKFFGAKGELA-DAIAELHHGGRL 97

Query: 96  PPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARL--LPRVNRMEWTILASA 153
               LPG+ +A  L L  G S GPE P++ +N  L   + ARL   P   R+  T+   A
Sbjct: 98  SYRFLPGMALASGLSLLFGSSAGPESPMIDINGGLGTWLAARLNLSPASTRI-LTLCGMA 156

Query: 154 GTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAG----ALTTGLFFHPHFS 209
             +   F +P+ A L F   +     V  ++ +   L++AAAG     + TG      + 
Sbjct: 157 AGMSVFFESPLGATL-FVLEIPHRRSVEFYEAIIPALISAAAGFTLFRVITGTTIGAIYR 215

Query: 210 LPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKN-PVLVLGIGGFIL 268
            P   Y  +   DI    ++  I  A G + V+   ++   +   +  P+L++ + GF++
Sbjct: 216 FPT--YDSLRPQDIGFAVLLGFIGAAVGTLFVFLDRQIQRWLTPYRQYPLLLIVVVGFLI 273

Query: 269 GILGVIGGPVSLFKGLDEMQQM--VANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIF 326
           G++ +I  P++LF G  +++Q+  V N+ +S      +A  KL AL +    GFRGG +F
Sbjct: 274 GVIALIH-PITLFYGERQIEQVIEVVNR-YSIGILLRVAFFKLLALSLCLRGGFRGGVVF 331

Query: 327 PAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPL 386
           P  FVG  +G+ +H+ +P  P ++ ++  +  + +VVT+   L L +   V+ +T +LPL
Sbjct: 332 PLFFVGACVGMAVHQALPNTPLSVALAGMMAAVTVVVTKTP-LGLAIILTVISHTAMLPL 390

Query: 387 LCIVMLPAWLLLAGKPMMMVNRPKQQPPH 415
           + I  L ++LL      +   R ++  P 
Sbjct: 391 MTIATLTSYLLTLPIGWIPSQRSREDTPD 419


>UniRef50_B0CCE6 Cl-channel, voltage gated n=3 Tax=Cyanobacteria RepID=B0CCE6_ACAM1
          Length = 465

 Score = 80.1 bits (196), Expect = 1e-13,   Method: Compositional matrix adjust.
 Identities = 103/427 (24%), Positives = 187/427 (43%), Gaps = 33/427 (7%)

Query: 5   RARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTL------GIAQDSPLW 58
           R  T   L + A  IG+   L+      +   L + +W  +P  +       + Q   +W
Sbjct: 24  RELTYSQLVICAALIGVFGGLVATAYYFVLETLMHGVWHTVPDRVVPYFPSWLPQQHYVW 83

Query: 59  IIGVLTLTGIAVGLVIRFSQGHAGPDPACEPLIGAP--VPPSALPGLIVALILGLAGGVS 116
           I    T+ G  VGLV+ F  G  G        I +P  +     P +I+A ++ +  G S
Sbjct: 84  IAS--TIGGFCVGLVLFF-MGLPGEMAQVVDKIHSPGKIDIRKTPAMIIASLVAITSGGS 140

Query: 117 LGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLN 175
            GPE P++ VN +    +G +L L   +    T    +  +GA FG P+ AAL       
Sbjct: 141 AGPEAPLVQVNGSFGSWLGEKLQLTTTSVRVLTFCGMSAALGAFFGAPIGAALF------ 194

Query: 176 GSSEVPLWDRL--FAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEM------TDILSGA 227
            + E+P    L  +  +  A   A+ +   F  +  + I  +   E       T++L G 
Sbjct: 195 -ALEIPHRKGLEYYEAIAPAVVSAIFSFAVFRINTGMTIGGFYHFETVPPLTPTNLLEGL 253

Query: 228 IVAAIAIAAGMVAVWCLPRL--HAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLD 285
           ++  I     ++ +    RL  H +     + +L+  +GG  +G++  +  P +LF   +
Sbjct: 254 VLGGIGAGVAVMFIGVF-RLVGHLLAPLEHHRILLATLGGLTIGLIA-LAFPQTLFFSEE 311

Query: 286 EMQQMVANQAFSTSDYFLL-AVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVP 344
           ++  ++   A     + L+ AV K+ A+ V   SGF GG IFP  F+G  +GL +   VP
Sbjct: 312 QIHTVIETGATLGITFLLMIAVAKMFAISVTLHSGFLGGFIFPLFFIGANVGLAISLMVP 371

Query: 345 AVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMM 404
            V   + + C +  + + VT+   +S  +   V+    +LP++ I    ++LL +   M+
Sbjct: 372 QVHPTLGMVCLMAAVNVAVTKTP-VSTSIILSVLSGMAMLPVIVISSFVSFLLTSQIAMI 430

Query: 405 MVNRPKQ 411
              R ++
Sbjct: 431 KTQRSRE 437


>UniRef50_Q3MBC4 Cl-channel, voltage gated n=7 Tax=Bacteria RepID=Q3MBC4_ANAVT
          Length = 434

 Score = 75.1 bits (183), Expect = 5e-12,   Method: Compositional matrix adjust.
 Identities = 81/313 (25%), Positives = 138/313 (44%), Gaps = 14/313 (4%)

Query: 62  VLTLTGIAVGLVIRFSQGHAGPDPACEPLI---GAPVPPSALPGLIVALILGLAGGVSLG 118
           V+ + G+ VGLVI F  G+ G        I   G  +     P +I+A ++ +AGG S G
Sbjct: 74  VMPIAGLIVGLVIHF-LGNPGEIAVIVDNIHFRGGRLDIRKNPAMILASLVSIAGGGSAG 132

Query: 119 PEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGS 177
           PE P++ V  +    +G RL L   +    ++ A A    ALFG P+  A+   + L+  
Sbjct: 133 PEAPLVQVTGSFGTWVGDRLGLQGEDMRSMSLAAMAAGFTALFGAPLGGAMFALEILHHQ 192

Query: 178 SEVPLWDRLFAPLMAAAAGALTTGLFFH----PHFSLPIAHYGQMEMTDILSGAIVAAIA 233
             +  ++ L   ++++ A  L   L  H    P +  P   Y    M D     +   I 
Sbjct: 193 HIIEYYEALMPAIVSSCASYLVFALITHLGIAPTWHFP--EYNLENMDDFAWAILFGIIG 250

Query: 234 IAAGMVAVWCLPRLHAMMHQMKNPVLV-LGIGGFILGILGVIGGPVSLFKGLDEMQQMVA 292
             AG + +        +   +  PV +   + G  LG L +   P++ + G  E++  V 
Sbjct: 251 AVAGWIFMTIFRTCDRLWAMLPVPVYIRTTLAGLGLGTLAIFL-PLTRYFGHQELES-VL 308

Query: 293 NQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITV 352
           N  FS     +LA+ K+A++ +    G+RGG I P  F G  +G  +   +P +   + +
Sbjct: 309 NTNFSVVFLLILALGKMASISLTVTGGWRGGFIIPLFFTGACVGKAIAILIPGLNPTLAM 368

Query: 353 SCAILGIVLVVTR 365
            C +  +   VTR
Sbjct: 369 ICTMSALNAGVTR 381


>UniRef50_Q0TTC6 Voltage-gated chloride channel family protein n=54 Tax=Firmicutes
           RepID=Q0TTC6_CLOP1
          Length = 418

 Score = 65.5 bits (158), Expect = 3e-09,   Method: Compositional matrix adjust.
 Identities = 83/319 (26%), Positives = 138/319 (43%), Gaps = 29/319 (9%)

Query: 39  NLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRFSQGHAGPDPACEPLIGAP---- 94
           + +W  LPG   +    P W I V ++ GI VGL     Q + G  P   P + A     
Sbjct: 37  HFMWNELPGKFNL----PYWTILVCSIGGILVGLC----QKYLGEYPKLMPEVMAEFKET 88

Query: 95  --VPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARLLPRVNRMEW----- 147
             V    +P   V+ ++ L  G SLGPE  ++ +   L+  +G  L   V   E      
Sbjct: 89  KRVDYKNVPKACVSALITLFFGASLGPEAALVNIIGGLSTLVGDFLKWIVKDKELEKYDS 148

Query: 148 --TILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALT--TGLF 203
             T  +   TIG +F  P+       +  + S    +   +++   AA  G L   + + 
Sbjct: 149 LVTEFSMEATIGLIFHAPLIGLTPLIEDDDSSVRKNIKTIVYSITTAAGFGVLILLSQID 208

Query: 204 FHPHFSLPIAHYGQME--MTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVL 261
             P F   I H+G     M++I+S   +    I   ++       LH +   +KN  ++ 
Sbjct: 209 NRPSF---IVHFGSFNLGMSEIISIISLIICGILMALLYGGYGKILHKIFLPLKNYKIIR 265

Query: 262 GIGGFILGILGVIGGPVSLFKGLDEMQQMVAN-QAFSTSDYFLLAVIKLAALVVAAASGF 320
            + G I+  +     P +LF G  E++ +V    + S     L++++KL    V  ++G+
Sbjct: 266 ALIGGIILGIVGTWLPYTLFSGEHEVKVLVKEWSSLSIRILILISLVKLFLTEVCLSTGW 325

Query: 321 RGGRIFPAVFVGVALGLML 339
           RGG IFP VF GV++G  L
Sbjct: 326 RGGHIFPVVFSGVSMGYAL 344


>UniRef50_C8XF05 Chloride channel core n=5 Tax=Actinomycetales RepID=C8XF05_NAKMY
          Length = 425

 Score = 57.4 bits (137), Expect = 1e-06,   Method: Compositional matrix adjust.
 Identities = 101/349 (28%), Positives = 154/349 (44%), Gaps = 39/349 (11%)

Query: 16  AVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIR 75
           A  +GI  S I    + + S +Q  L+  LP ++        W +  L L G+  GL IR
Sbjct: 4   AAILGIPISAIAYGFLALVSKIQQYLFTDLPTSVTGGPAPAWWPLPWLLLCGLLTGLTIR 63

Query: 76  FSQGHAGPDPACE-PLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAI 134
           +  G+ G  PA      GAP     L G+ +A +  L+ G  LGPE P++ +   LA  +
Sbjct: 64  YLPGNCGHSPAFGFQTGGAPPTGKELVGVFLAALTTLSLGAVLGPEAPLIAIGGGLAALV 123

Query: 135 GARLLPRVNRMEWTILASAGTIGA---LFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLM 191
              +      M  TI+ASAG+  A   L G+P+  A +  +   G     L       L+
Sbjct: 124 VRLVRSDAPPMAVTIMASAGSFAAISTLLGSPLLGAFLIMEA-AGIGGATLSLVALPGLL 182

Query: 192 AAAAGALT-------TGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAV--- 241
           A+  GAL        TGL     FSL       +      SG  VA +  A  M AV   
Sbjct: 183 ASGIGALIFVGLDNLTGLG---TFSL------SLGTVPPDSGPTVATLCWAIVMGAVGAL 233

Query: 242 --WCLPR----LHAMMHQMKNPVLVLGIGGFILGILGVIGGPVS-------LFKGLDEMQ 288
             W +      L  ++H   N VLV G  G ++G   ++   ++       LF G D M 
Sbjct: 234 LAWVIRSGALSLRPLVH--TNRVLVTGALGLLVGAAAMVYQLITGHSFTQVLFSGQDAMP 291

Query: 289 QMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGL 337
           ++V+N A  +    ++ ++  A     + S FRGG +FP++F+G ALG+
Sbjct: 292 ELVSNAAQYSVGALIVLIVAKAFAYSLSLSAFRGGPVFPSMFIGAALGI 340


>UniRef50_C6JBA2 Voltage-gated chloride channel family protein n=1 Tax=Ruminococcus
           sp. 5_1_39BFAA RepID=C6JBA2_9FIRM
          Length = 424

 Score = 53.9 bits (128), Expect = 1e-05,   Method: Compositional matrix adjust.
 Identities = 99/441 (22%), Positives = 181/441 (41%), Gaps = 64/441 (14%)

Query: 7   RTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLT 66
           +  L L L    IG  +  ++ +++KI +V    LW+  PG   +    P + I ++ + 
Sbjct: 13  KNQLELWLFCALIGAVAGALVWILLKIMAVGTEFLWKWFPGKTSV----PYYTI-LICVA 67

Query: 67  GIAVGLVIRFSQGHAGPDPAC---EPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPI 123
           G A+  + R   G    D      +  +        +  ++VA +L L  G S+GPE  +
Sbjct: 68  GAAIIGIFRKIFGDYPEDLETVMEKVRVEKRYEYKNMLVMMVAALLPLLIGSSVGPEAGL 127

Query: 124 MTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPL 182
             + + L    G  L   + N   ++ + +A ++  LF  P+    IF    N   ++  
Sbjct: 128 TGIIVGLCYWAGDNLKFAKQNTRNYSQIGAAVSMSVLFHAPLFG--IFEVEENSEEDLAA 185

Query: 183 W---DRLFAPLMAAAAG-ALTTGLFFHPHFSLPIAHYGQMEMTDI-LSGAIVAAIAIAAG 237
                +LF   +A AAG ++  GL     F   ++ +   +M +I     ++  + I  G
Sbjct: 186 LTKGSKLFIYGIALAAGTSIYAGL--SALFGAGLSGFPSFDMVEIQRKDYLLMILYILCG 243

Query: 238 MVAVWCLPRLHAMMHQMKN--PVLVLGI-GGFILGILGVIGGPVSLFKGLDEMQQMVANQ 294
           ++  +     H +   + N  P +V  I  G  LGI G    PV +F G D+M  ++   
Sbjct: 244 LILAYFYQATHKLTGNISNRFPAVVKEIFAGLCLGITGSFL-PVLMFSGEDQMGTLMK-- 300

Query: 295 AFSTSDYFLLAVIKLAALVVAAAS-----GFRGGRIFPAVFVGVALGLMLHEHVPAVPAA 349
             + + Y  LA+I +A   +   +     G +GG  FP +F GV +G  +          
Sbjct: 301 --TYTSYLPLALIAIAFFKLLLTNLCIQFGLKGGHFFPVIFAGVCMGYGMA--------- 349

Query: 350 ITVSCAILGIVLVVTRDGWLSLFMAAVVVPN-----------TTLLPLLCI-VMLPAWLL 397
                     +L    DG   +F AA+V  +            T+L  LC  V +  W+ 
Sbjct: 350 ----------MLTCGPDGGHVVFGAAIVTASLLGGIMKKPLAVTMLLFLCFPVKMFIWIF 399

Query: 398 LAGK--PMMMVNRPKQQPPHD 416
           +A      ++  +P+Q+P  +
Sbjct: 400 IAAAVGSKLITLKPEQEPSAN 420


>UniRef50_O54193 Putative membrane protein n=3 Tax=Streptomyces RepID=O54193_STRCO
          Length = 452

 Score = 53.9 bits (128), Expect = 1e-05,   Method: Compositional matrix adjust.
 Identities = 50/154 (32%), Positives = 74/154 (48%), Gaps = 4/154 (2%)

Query: 20  GIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRFSQG 79
           G+  +L     + +   LQ+ +W  LP   G       W +  L L G+ +  ++    G
Sbjct: 36  GVPIALACFFFVGLQHELQHWVWTSLPEAAGYDTPPWWWPLPALVLAGLILAPIVTRMPG 95

Query: 80  HAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARLL 139
             G  P    L GAPV P ALPG ++A +  L  GV LGPE P+M V   LA+    R  
Sbjct: 96  GGGHLP-VNGLGGAPVGPRALPGAVLAALATLPLGVVLGPEAPLMAVGSGLALLAVRRAG 154

Query: 140 PRVNRMEWTILASAGT---IGALFGTPVAAALIF 170
              ++    ILA+AG+   I  + G P+AAA++ 
Sbjct: 155 AGGDQQASAILATAGSTAAISTILGGPIAAAVLL 188


>UniRef50_C1DC80 Probable voltage-gated chloride channel family protein n=1
           Tax=Laribacter hongkongensis HLHK9 RepID=C1DC80_LARHH
          Length = 460

 Score = 52.0 bits (123), Expect = 5e-05,   Method: Compositional matrix adjust.
 Identities = 74/269 (27%), Positives = 129/269 (47%), Gaps = 23/269 (8%)

Query: 104 IVALILGLAGGVSLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGAL-FG 161
           ++A + G++ G + G E PI+ +  AL  ++G RL +   N +  TILA      A  F 
Sbjct: 132 VLATLTGISAGGTFGYEGPIIQIGAALTHSLGRRLGIHSENAIRTTILAGGAASVAAAFN 191

Query: 162 TPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAA--AGALTTGLF-FHPHFSLPIAHY--- 215
           TP+A  ++F+    G S  P   R    ++ A   AG +T   F  + +F     H+   
Sbjct: 192 TPLAG-IVFAIEEMGRSFEP---RASGIILTAVILAGLITMAAFGNYDYFGTTAIHFRAL 247

Query: 216 -GQMEMTDILSGAIVAAI-AIAA-GMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILG 272
            G      +L+G I  A  A+AA  M+AV    R   +  + + P+L   + G ++ ++G
Sbjct: 248 GGSQLAAVLLTGVICGAFGALAARAMLAVSTGSRSRLLAWRGRQPMLFAAVCGVLIALIG 307

Query: 273 VIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVG 332
           +     S   G +E  ++V   A    ++F   ++KL  ++V+  SG  GG + P++ +G
Sbjct: 308 IATHGESFGTGYNEAHRIVTGNA-QGLEWF--GIVKLFTMLVSQISGVTGGVLAPSLAIG 364

Query: 333 VALGLMLHEHVPAV-PAAITVSCAILGIV 360
              G  +   +P V P A+    A+LG+V
Sbjct: 365 AGFGYDIGRLLPEVHPQAM----ALLGMV 389


>UniRef50_A3YZH8 Chloride channel-like protein n=1 Tax=Synechococcus sp. WH 5701
           RepID=A3YZH8_9SYNE
          Length = 659

 Score = 52.0 bits (123), Expect = 5e-05,   Method: Compositional matrix adjust.
 Identities = 84/284 (29%), Positives = 131/284 (46%), Gaps = 19/284 (6%)

Query: 65  LTGIAVGLVIRFSQGHAGPDPACEPLIGAPVPP-SALPGL-IVALILGLAGGVSLGPEHP 122
           L G+AVGL+ +  +      P+   +     P    LPGL +VA  L L  G SLGPE P
Sbjct: 141 LGGVAVGLLRQLGRDLGPSLPSLMAMADGAAPALPRLPGLRLVAASLSLGSGASLGPEGP 200

Query: 123 IMTV--NIALAVAIGARLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEV 180
            +    N+ L V +  RL P   +        A  + A F  P+A   +F       S +
Sbjct: 201 SVESGGNLGLWVGLRGRLPPESQKAL-VAAGVAAGLAAGFKAPIAG--VFFAFEGAYSAI 257

Query: 181 PLWDRLFAPLMAAAAGALTTGLFF--HPHFSLPIAH-YGQMEMTDILSGAIVAAIAIAAG 237
           P    L A L+AA A +L T L     P F LP       +E+   L   +VA++ ++  
Sbjct: 258 PGRPSLRAVLVAAVASSLVTQLCLGDEPIFRLPAYEVRSPLELPLYLGLGLVASL-MSWA 316

Query: 238 MVAVWCLPRLHAMMHQMKN-PV-LVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQ- 294
           +V++    R   + H     P+ L+ G+GG  +G+L  +G P  L  G D ++ ++ ++ 
Sbjct: 317 LVSLLAAGRSEPVQHWFSRLPLWLINGLGGLAVGVL-ALGFPQVLGVGYDTIEALLGSEG 375

Query: 295 --AFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALG 336
             A +T    L+  +    L  + A+GF GG   PA+F+G  LG
Sbjct: 376 GVALTTLAALLVVKLLATGL--SNATGFVGGGFAPALFLGAVLG 417


>UniRef50_B8C337 Chloride channel protein (Fragment) n=1 Tax=Thalassiosira
           pseudonana RepID=B8C337_THAPS
          Length = 312

 Score = 49.7 bits (117), Expect = 2e-04,   Method: Compositional matrix adjust.
 Identities = 64/258 (24%), Positives = 106/258 (41%), Gaps = 33/258 (12%)

Query: 111 LAGGVSLGPEHPIMTVNIALAVAIGARLLPRVNRM---EWTILA--SAGTIGALFGTPVA 165
           L  G SLGPE P +   ++L   +    + RVNR    +  +LA  +A  + A F  P++
Sbjct: 14  LGTGNSLGPEGPSVEAGMSLNYEMTE--VQRVNRKMARDRLLLACGAAAGVSAGFNAPLS 71

Query: 166 AALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHY---------- 215
                 + +  + ++ +     A L+A+   ALT  L      SL +  +          
Sbjct: 72  GVFFALEIVQNAFQINIS----AILLASVVSALTIQLLLGSELSLRLGSFDFKNPLLELP 127

Query: 216 -----GQME--MTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFIL 268
                G M   +  I SG    +  +  G      +      + +   P+    I   I 
Sbjct: 128 LYLLLGAMSGVVAAIFSGVAQYSKTVFDGEEGPEIVQETFRQIPKYAKPL----IASLIC 183

Query: 269 GILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPA 328
           G++G+   P  LF G + +  +  N   ST   FLL + KL    ++A+SG  GG   P+
Sbjct: 184 GVVGIYV-PQVLFFGYETLNGLFLNNDISTPYLFLLLIAKLMTTAISASSGLVGGTFAPS 242

Query: 329 VFVGVALGLMLHEHVPAV 346
           +F+G  LG + H   P V
Sbjct: 243 LFLGGVLGAVFHNIYPIV 260


>UniRef50_C3ATP4 Voltage-gated chloride channel n=9 Tax=Bacillus RepID=C3ATP4_BACMY
          Length = 404

 Score = 49.3 bits (116), Expect = 3e-04,   Method: Compositional matrix adjust.
 Identities = 78/324 (24%), Positives = 134/324 (41%), Gaps = 21/324 (6%)

Query: 39  NLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRFSQGHAGPDPACEPLIGAPVPPS 98
           + +W+ LP    +    P +    +T+ G   G +I  SQ + G  P   P + A    +
Sbjct: 26  HFVWEYLPKEFAL----PSYYTICVTIIG---GFLIGLSQKYFGTYPRLMPEVMAEYKKT 78

Query: 99  A------LPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARLLPRVNRME-WTILA 151
                  +    +  I+ L  G SLGPE  ++ +   L   +G R    V  M+  T + 
Sbjct: 79  GRIEYRFVHQATLTAIIVLVFGASLGPEAALVGIIGGLCTWVGDRFHFAVKGMQGLTEIG 138

Query: 152 SAGTIGALFGTPVAAALIFSQTLNGS-SEVPLWDRLFAPLMAAAAGALTTGLF--FHPHF 208
              T+  +F  P+   L  S+  N   +EV    +    +    AG     L   F    
Sbjct: 139 IGATLSVIFNAPLFGYLAPSENENERLAEVSKGKKAIVYVATTLAGFSVYLLLSKFDNRG 198

Query: 209 SLPIAHYGQ--MEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGF 266
           S  I ++G+    + + ++   +A I  + G         L  ++H  +   L LGI G 
Sbjct: 199 SF-IVNFGEGSFALHEWVAFLPLACIGASIGYFYFKVEHTLEKVVHPFQEYKLTLGIIGG 257

Query: 267 ILGILGVIGGPVSLFKGLDEMQQMVAN-QAFSTSDYFLLAVIKLAALVVAAASGFRGGRI 325
           I+  +     P ++F G  +++++V      S    FL  V+KL    V   +G+RGG I
Sbjct: 258 IILGIAGTFLPYTMFSGEHQLKELVNEWTELSFGVLFLSGVLKLCITAVCLNTGWRGGHI 317

Query: 326 FPAVFVGVALGLMLHEHVPAVPAA 349
           FP +F G ++G  +   +P  P A
Sbjct: 318 FPIIFAGASIGYAMATVIPLDPIA 341


>UniRef50_B7G8L3 Predicted protein n=1 Tax=Phaeodactylum tricornutum CCAP 1055/1
           RepID=B7G8L3_PHATR
          Length = 649

 Score = 48.5 bits (114), Expect = 5e-04,   Method: Compositional matrix adjust.
 Identities = 31/95 (32%), Positives = 51/95 (53%), Gaps = 2/95 (2%)

Query: 247 LHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAV 306
           + + M  +  PV  + IGGF  G++G++  P  LF G + +  ++AN +  TS  F L +
Sbjct: 416 IQSFMSCLPEPVKPV-IGGFACGLVGLVF-PQILFFGYETLNSLLANASLPTSLLFSLLI 473

Query: 307 IKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHE 341
           +K     V+A SG  GG   P++F+G  +G   H 
Sbjct: 474 VKTIMTAVSAGSGLVGGTFAPSLFLGAMVGAAFHN 508


>UniRef50_D0R1Y7 Putative uncharacterized protein n=9 Tax=Lactobacillus
           RepID=D0R1Y7_LACJF
          Length = 397

 Score = 48.1 bits (113), Expect = 6e-04,   Method: Compositional matrix adjust.
 Identities = 42/130 (32%), Positives = 64/130 (49%), Gaps = 16/130 (12%)

Query: 239 VAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFST 298
           V  W LP L           L   + G +L +L ++    +LF G   +    +  A S 
Sbjct: 243 VETWALPAL-----------LKATLWGIVLSVLTLVTN-YALFSGEFHIVSF-SKTALSY 289

Query: 299 SDYFLL--AVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAI 356
           S  FLL  A+IK  +     A G+RGG+IFPA+F  VA+G  + + +P  P AITVS A+
Sbjct: 290 SPLFLLLIALIKTISTHAGFAMGWRGGKIFPAIFSSVAVGAAISQFIPIQP-AITVSLAV 348

Query: 357 LGIVLVVTRD 366
           +  + ++   
Sbjct: 349 VASITIILEK 358


>UniRef50_C2KWR2 Chloride carrier/channel (ClC) family transporter n=1
           Tax=Oribacterium sinus F0268 RepID=C2KWR2_9FIRM
          Length = 442

 Score = 47.0 bits (110), Expect = 0.001,   Method: Compositional matrix adjust.
 Identities = 77/302 (25%), Positives = 128/302 (42%), Gaps = 31/302 (10%)

Query: 92  GAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARLLPRVNRMEWTILA 151
           G  +P    P +I + +L    G S+G E   + V  +L  +IG R+L    + +  I+ 
Sbjct: 112 GEKLPVEMAPLIIFSTVLSHLFGASVGREGAALQVGGSLGSSIG-RVLHLSEKEQRRIMM 170

Query: 152 S--AGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHP--H 207
              +     LFGTP+AAA IF+  L       +    +  L+     ALT   F     H
Sbjct: 171 CGMSAAFSGLFGTPIAAA-IFAIEL-----CTVGSIYYTALLPCTVSALTAHFFAEKVIH 224

Query: 208 FSLP---IAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQ-MKNPVLVLGI 263
              P   ++   +M+ +  L   ++A  A    +V V C  +   +  +   NP L + +
Sbjct: 225 AEEPDLALSLMAEMDWSSALYTLLLAIAAALVSIVFVSCAHKAKDLFSKYFPNPYLRIFV 284

Query: 264 GGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAV-IKLAALVVAAASGFRG 322
            G I+ +L  +    +++ G   +Q +        +  FL A  +K+    V+   GF+G
Sbjct: 285 SGAIV-LLATLALNTNIYNGTG-IQLITQTIHEPGTKIFLFAFFLKILFTSVSLGGGFQG 342

Query: 323 GRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTT 382
           G I P++F+G  LG  L   +P  P+     CA LG+          +LF      P T 
Sbjct: 343 GEIVPSLFIGATLGNALSRFLPLDPSL----CAALGMT---------ALFCGVTNCPLTA 389

Query: 383 LL 384
           LL
Sbjct: 390 LL 391


>UniRef50_B0G1X5 Putative uncharacterized protein n=1 Tax=Dorea formicigenerans ATCC
           27755 RepID=B0G1X5_9FIRM
          Length = 428

 Score = 46.2 bits (108), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 88/370 (23%), Positives = 160/370 (43%), Gaps = 36/370 (9%)

Query: 57  LWIIGVLTLTGIAVGLVIRFS--QGHAGPDPACEPLIGAPVPPSALPGLIVALIL----- 109
           +W++ +L   G+ +  +   +  + +AG D     L+      + +PG +  LIL     
Sbjct: 60  MWMVYLLPFAGLMIVFLYHVTGQEKNAGTDMV---LMVVRSDQNTMPGRVAPLILIATAL 116

Query: 110 -GLAGGVSLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAA 167
             L GG S G E   +    +L   +G ++ L   ++   T+   +    ALFGTP+AAA
Sbjct: 117 THLFGG-SAGREGAALQFGASLGNWLGRKIHLNESDKRIMTLAGMSAAFAALFGTPMAAA 175

Query: 168 LIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDIL--- 224
           +   + +  S  +  +  L   + +A  G   +        + P   Y   E+ +     
Sbjct: 176 VFPMEVI--SVGIMYYAALVPCVFSAFIGERISIFMGVRTLTAP---YPVEEVPNFYGIA 230

Query: 225 -SGAIVAAIAIA-AGMVAVWCLPRLHAMMHQMK----NPVLVLGIGGFILGILGVIGGPV 278
              AI+ AI  A AG  A++C+  LH    Q+K    NP L + +GG  + +L  I G  
Sbjct: 231 WGKAILLAICFAFAG--ALFCV-MLHIFEKQLKKWFQNPYLRVFVGGVTVVLLWKITG-T 286

Query: 279 SLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLM 338
             + GL         Q+F+      + ++K+    +   SGF+GG I P++F+G   G  
Sbjct: 287 DTYLGLG---GGTIAQSFAEPQKLWVFLLKILFTCITLCSGFKGGEIVPSLFIGATFGSA 343

Query: 339 LHEHVPAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL 398
           L   +  +P  I  +C ++G+   VT    +S  + A  +     +P  C V+  ++LL 
Sbjct: 344 LAP-IFGLPVDICAACGMVGVFCAVTNSP-ISSLLIAFELFGFAGMPYFCTVIAVSYLLS 401

Query: 399 AGKPMMMVNR 408
             + +    +
Sbjct: 402 GYQSLYKAQK 411


>UniRef50_A5GMC1 Uncharacterized conserved membrane protein n=3 Tax=Synechococcus
           RepID=A5GMC1_SYNPW
          Length = 400

 Score = 46.2 bits (108), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 34/109 (31%), Positives = 57/109 (52%), Gaps = 6/109 (5%)

Query: 256 NPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMV-ANQAFSTSDYFLLAVIKLAALVV 314
            PVL   I GF L  L     P+S+F G ++++ +V    + ST    + A+ KL  + +
Sbjct: 259 TPVLTGVILGFSLWAL-----PLSVFSGENQLKPLVLGAWSLSTGMLLMSALFKLLLVGL 313

Query: 315 AAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLVV 363
              +G++GG+ FP +    ALG+ LHE +P +    + S  ++G  L V
Sbjct: 314 CLETGWKGGQFFPVILASSALGMGLHECLPFLGGLQSWSSGVVGGSLSV 362


>UniRef50_C4Z1M2 Chloride channel protein, CIC family n=1 Tax=Eubacterium eligens
           ATCC 27750 RepID=C4Z1M2_EUBE2
          Length = 425

 Score = 45.4 bits (106), Expect = 0.004,   Method: Compositional matrix adjust.
 Identities = 75/334 (22%), Positives = 145/334 (43%), Gaps = 31/334 (9%)

Query: 94  PVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARLLPRVNRMEWTILASA 153
            VP    P +I++ +L    G S G E   + V  AL     A+L  + +  +  I+   
Sbjct: 101 EVPGRVAPLIIISTLLTHLCGGSAGREGAALQVGGALGNTF-AKLF-KFDEKDTRIMIMC 158

Query: 154 G---TIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAA-AAGALTTGLFFHPHFS 209
           G      ALFGTP+AAA+   + +  S  V  +  L   ++AA  A  + + L       
Sbjct: 159 GMSACFSALFGTPIAAAVFSMEVI--SVGVMYYAALVPCVLAAFVAQGIASAL------G 210

Query: 210 LPIAHY--GQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHA----MMHQMKNPVLVLGI 263
           L   H+   ++     ++G+    +++   +V++     LH      ++ + NP + + I
Sbjct: 211 LESTHFVVDEIASFSFINGSKFIIMSVLFALVSILLCVVLHGTSKLYINYINNPYIRIII 270

Query: 264 GG-FILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRG 322
            G  ++ +  + G    L  G D     +  ++F TS  + + ++K+    V    GF+G
Sbjct: 271 AGVLVISMRYIFGTTDYLGAGSD-----IIAKSFVTSCAWYVFLLKMLFTAVTLGGGFKG 325

Query: 323 GRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTT 382
           G I P +FVG  LG  L   +  +P  +  +C ++ +   VT     S  ++  +   +T
Sbjct: 326 GEIVPTLFVGATLGSFLAP-IFGLPVGLCAACGMVSVFCGVTNCPLTSFILSIEMFGAST 384

Query: 383 L-LPLLCI---VMLPAWLLLAGKPMMMVNRPKQQ 412
           +   +LCI    +L  +  L     ++ ++ K +
Sbjct: 385 MKFTILCIALSYLLSGYYSLYNSQKIVYSKYKTE 418


>UniRef50_B1LX30 Chloride channel core n=18 Tax=Alphaproteobacteria
           RepID=B1LX30_METRJ
          Length = 459

 Score = 45.4 bits (106), Expect = 0.004,   Method: Compositional matrix adjust.
 Identities = 74/284 (26%), Positives = 121/284 (42%), Gaps = 34/284 (11%)

Query: 95  VPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARLLPRVNRMEWTILASAG 154
           + P    G ++ L LGL  G S G E P + V  A+  A G RL P        +   A 
Sbjct: 128 ISPRVAFGKVLVLFLGLFCGASAGREGPTVQVGAAIMAAFG-RLTPE-RLPGLLLAGGAA 185

Query: 155 TIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAH 214
            + A F TP+A  +   + L  + E      + A ++  AAG  + GL         + +
Sbjct: 186 GVAAAFNTPLAGIVFGIEELGRAYEARSSGLIVAGIV--AAGLTSLGL---------LGN 234

Query: 215 YGQMEMTD----ILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQ----------MKNPVLV 260
           Y     TD    + +G IV  +A+  G+ A     RL  +  +           K PV+ 
Sbjct: 235 YTYFGTTDAALPLAAGWIVPLVAVVGGL-AGGLFSRLVILFARGLPGAAGRAIRKRPVIF 293

Query: 261 LGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGF 320
               G  + + G+  G  +   G +E + ++   A +   Y   A +K AA V+++ SG 
Sbjct: 294 AAACGLCVALCGLASGGAAYGTGYEEAKAILHGDAAAGWTY---APLKFAATVLSSISGI 350

Query: 321 RGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLVVT 364
            GG   P++ VG  LG  +H  +P +P    V   ++G+V  +T
Sbjct: 351 PGGLFAPSLAVGAGLGGTVHGLLPGMPVGAVV---LIGMVAYLT 391


>UniRef50_C4KYZ9 Chloride channel core n=1 Tax=Exiguobacterium sp. AT1b
           RepID=C4KYZ9_EXISA
          Length = 394

 Score = 45.1 bits (105), Expect = 0.004,   Method: Compositional matrix adjust.
 Identities = 87/338 (25%), Positives = 140/338 (41%), Gaps = 41/338 (12%)

Query: 17  VAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRF 76
           + IG+ S L L VV K   V+    W  +P       D P ++  V  + G+++GL+   
Sbjct: 15  IIIGLVSWLFLSVVYKGIHVV----WHTVPEQF----DIPFYLFLVPVIAGVSIGLL--- 63

Query: 77  SQGHAGPDPACEPLIGAPVPPSA-----LPGLI-VALILGLAGGVSLGPEHPIMTVNIAL 130
            Q   G  P   P +      +      L G   +  +L L GG SLGPE  ++ +   L
Sbjct: 64  -QRRYGQMPRLMPEVMEERKDTGRIDYRLIGFTTLTALLVLIGGASLGPEAALVGIVGGL 122

Query: 131 AVAIGARLLPRVNRMEWTILASAG---TIGALFGTPVAAALIFSQTLNGSSEVPLWDRLF 187
                 R+  R  R E   L   G    +G +F  P+  A+   +  N   + P+ + L 
Sbjct: 123 TTWFSERI--RYVRQELGELQEVGHAVVLGIVFNAPLFGAIAAEE--NEQKKQPMLN-LL 177

Query: 188 APLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVW-CLPR 246
           A L       L   L   P F   I  + +ME   +    I   + + +G++  W  L  
Sbjct: 178 ATLAGIGTFYLLNQLDERPPF---IIKFPEMETIQLNWTVI---LIVLSGILLGWLYLIS 231

Query: 247 LHAMMHQMKN-PVLVLG-IGGFILGILGVIGGPVSLFKGLDEMQQMVANQAF---STSDY 301
            HAMM    N P+L+L  +GG  +G + ++  P  LF G + + + +         T   
Sbjct: 232 EHAMMQLFSNVPILLLTTLGGVGIGGMALLY-PDLLFSGEETILEYIDEWRLIPLYTLLL 290

Query: 302 FLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLML 339
           F +  +   A  +A  +G+RGG I+P +F    LG   
Sbjct: 291 FSVLKLLFTAFCLA--TGWRGGHIYPLLFSSFTLGYFF 326


>UniRef50_Q38V51 Hypothetical integral membrane protein n=1 Tax=Lactobacillus sakei
           subsp. sakei 23K RepID=Q38V51_LACSS
          Length = 274

 Score = 45.1 bits (105), Expect = 0.005,   Method: Compositional matrix adjust.
 Identities = 40/127 (31%), Positives = 56/127 (44%), Gaps = 15/127 (11%)

Query: 239 VAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFST 298
           +  WC      +   +  PVL+  I G  LG  G++  P  LF G   +     +    +
Sbjct: 116 IEQWC----QWLADTIHRPVLLAVIAGICLGACGLLS-PYLLFSGEHYLLTFTKSGLDQS 170

Query: 299 SDYFLLAVIKLAALVVAA---ASGFRGGRIFPAVFVGVALGLMLHEHVPAVP-----AAI 350
             Y LL  I L   V+     A G+RGG+IFPA+F   A+GL L    P  P       +
Sbjct: 171 FGYLLL--IGLGKTVLTNLIFAFGWRGGKIFPAIFASAAIGLSLAVLFPYTPGLLVATVV 228

Query: 351 TVSCAIL 357
            VSC I+
Sbjct: 229 AVSCTII 235


>UniRef50_C0W1S0 H(+)/Cl(-) exchange transporter n=1 Tax=Actinomyces coleocanis DSM
           15436 RepID=C0W1S0_9ACTO
          Length = 501

 Score = 44.7 bits (104), Expect = 0.006,   Method: Compositional matrix adjust.
 Identities = 103/450 (22%), Positives = 177/450 (39%), Gaps = 64/450 (14%)

Query: 1   MLHPRARTMLLLSLPAVAIGIASSLI-------LIVVMKIASVLQNLLWQRLPGTLGIAQ 53
            +   AR++ LL   A  +GI++ LI       L  V+++   L +LL  +    LG   
Sbjct: 37  FIDAEARSLFLLCFAAALVGISTGLIAASFRIGLEWVLELRFGLIDLLDGQ--AVLGFI- 93

Query: 54  DSPLWIIGVLTLTGIAVGLVIRFSQGHAGPD-PACEPLIGAPVPPSA---LPGLIVALIL 109
              L+I     LTG++  LV + S    G   P  E ++   + P     LP   V  ++
Sbjct: 94  ---LFIAVTTILTGLSALLVAKVSPDAEGSGIPRVEAIVNGHLEPGRSRILPVKFVGGLM 150

Query: 110 GLAGGVSLGPEHPIMTVNIALAVAIGARLLPRVNRMEWTIL---ASAGTIGALFGTPVAA 166
            +  G+ LG E P++ +  + A  +      R+   +  +L    +A  +   F  P+A 
Sbjct: 151 AIGSGLMLGREGPLVQMGASAAYTVNKYF--RLKDDDLRVLMGAGAAAGLATAFNAPIAG 208

Query: 167 ALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDI--- 223
            +   + L    ++       A L+A+ AG +++ L     F   I    Q+  T I   
Sbjct: 209 GVFVLEELLKRFDI---RTTLATLVASGAGFVSSILLVDSRFEFIIGWAPQVTNTSIHWV 265

Query: 224 -LSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLG-IGGFILGILGVIGGPVSLF 281
            L G +   + I      +WCL         +K P  + G + G +LGI+G      ++ 
Sbjct: 266 VLIGILCGFLGIIYNDYVMWCL----RFADTLKPPAFIRGGVVGLVLGIVGWFAP--AIV 319

Query: 282 KGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLH- 340
            G D + Q              +  ++     ++ A+G  GG   P + +G  LG+++  
Sbjct: 320 GGGDNLTQQALLGNGGLGLAVAILAVRFILGPISYAAGTPGGLFAPQLVIGSTLGMIIGI 379

Query: 341 -------EHVPAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLC----- 388
                   H P+VPAA     A++G          LS F +A V    T L L       
Sbjct: 380 IANSVQPNHSPSVPAA-----ALIG----------LSAFFSATVRTPITGLILASEMTGN 424

Query: 389 IVMLPAWLLLAGKPMMMVNRPKQQPPHDNV 418
           +  LPA L      M +    K  P ++ +
Sbjct: 425 VTALPAMLAACAVAMYIATVAKSDPIYERL 454


>UniRef50_B5YBN2 SycA n=1 Tax=Dictyoglomus thermophilum H-6-12 RepID=B5YBN2_DICT6
          Length = 426

 Score = 43.5 bits (101), Expect = 0.016,   Method: Compositional matrix adjust.
 Identities = 69/276 (25%), Positives = 120/276 (43%), Gaps = 29/276 (10%)

Query: 77  SQGHAGPDPACEPL--IGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAI 134
           ++GH G +   E +      + P  +P  ++  I+ L+ G S G E P   +   LA +I
Sbjct: 75  AKGH-GTEKVIESIHKRNGKINPLVVPIKLIGTIITLSAGGSAGKEGPSAQIGAGLA-SI 132

Query: 135 GARL--LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTL---NGSSEVPLWDRLFAP 189
            A +  L   NR +  I   +    ++FGTP+A A+   + L   N   E  L   +   
Sbjct: 133 FADIFKLDDRNRKKLVICGISAGFASVFGTPIAGAIFGIEVLIVGNMFYEALLPSFIAGI 192

Query: 190 LMAAAAGALTTGLFFHP---HFSLPIAHYGQMEMTDILSGAIVAAIAIA-AGMVAVWCLP 245
           +    +  L     +HP   ++S    H+ +         AI+A I +    ++ +  L 
Sbjct: 193 VSFQVSSKLGISYSYHPLSFNYSFNELHFAE---------AIIAGIFLGLVSIIFIETLN 243

Query: 246 RLHAMMHQMK--NPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFL 303
               +  ++K  NPV  L IGG IL +L +I     L  G+D +++ +  +  +   YF 
Sbjct: 244 FFEDIYKKLKIWNPVKGL-IGGSILVLLTLIFSKNFLGLGIDTIERALNGERIAW--YFF 300

Query: 304 LAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLML 339
           L  +K+   ++  + G  GG I P  F+G   G  L
Sbjct: 301 L--VKIIFTIITLSFGGSGGIITPIFFIGSTAGNFL 334


>UniRef50_A5EFE0 CLC-type chloride channel protein n=3 Tax=Bradyrhizobium
           RepID=A5EFE0_BRASB
          Length = 595

 Score = 43.5 bits (101), Expect = 0.017,   Method: Compositional matrix adjust.
 Identities = 47/156 (30%), Positives = 79/156 (50%), Gaps = 16/156 (10%)

Query: 188 APLMAAA-AGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPR 246
           AP++AA+ AGALT+       +SL I   G +     ++  ++A +    G+V +   P 
Sbjct: 211 APILAASLAGALTSQYLTGAPYSLEIQKVGAVGFEQYIALFVLALLVAGIGIVVMRASPA 270

Query: 247 LHAMMHQMKNPV-LVLGIGGFILGILGVIGGPVSLFKG-----LDEMQQMVANQAFSTSD 300
           +  +   ++ PV L   IGG  +G + ++  P  L  G     LD  ++M      +   
Sbjct: 271 VERLF--VRIPVWLRPAIGGVCVGAMAIVT-PQVLAAGHGAMLLDLHREMAVGMIAT--- 324

Query: 301 YFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALG 336
              + V+KLAA +++ ASGFRGG  F ++F+G  LG
Sbjct: 325 ---IIVLKLAACLISLASGFRGGLFFASLFIGSLLG 357


>UniRef50_B5ZGR7 Chloride channel core n=11 Tax=Bacteria RepID=B5ZGR7_GLUDA
          Length = 457

 Score = 43.5 bits (101), Expect = 0.017,   Method: Compositional matrix adjust.
 Identities = 87/297 (29%), Positives = 126/297 (42%), Gaps = 30/297 (10%)

Query: 63  LTLTGIAVGLVIRF--SQGHAGP----DPACEPLIGAPV--PPSALPGLIVALILGLAGG 114
           L L G+AVGL       Q   G     D   EP  G P+   P  L G +V+ + G    
Sbjct: 74  LPLAGVAVGLTYHVLGRQAEGGNNLIVDQIHEPGGGVPLRMAPLVLAGTVVSHLFG---- 129

Query: 115 VSLGPEHPIMTVNIALAVAIGARLLPRVNRMEWTILASAGT---IGALFGTPVAAALIFS 171
            S+G E     V I  ++A G   L R+   E   L +AG     G +FGTPVA A+   
Sbjct: 130 ASVGREG--TAVQIGGSIASGFTRLFRLTAREVRTLLTAGIAAGFGGVFGTPVAGAVFAM 187

Query: 172 QTLN-GSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHY----GQMEMTDILSG 226
           + L+ G  E      +    +AA       G+  H  ++LP   Y    G     D L  
Sbjct: 188 EVLSIGRMEYSAIVPVAVAAIAADWTCHAWGIH-HVTYTLPFRGYPDAGGTAFHADPLLL 246

Query: 227 AIVAAIAIAAGMVAVWCLPRLHAM--MHQMKNPVLVL--GIGGFILGILGVIGGPVSLFK 282
           A VAA  +A G+ ++     +H +  + +   PV  L   IGG +  +L  + G      
Sbjct: 247 ARVAAAGVAFGLASLAFAQAVHRLGAVFRALCPVAWLRPAIGGVLTIVLVFLAGSRDYLG 306

Query: 283 -GLDEMQQMVAN--QAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALG 336
            G+   +   A+    F  + Y    + KLA  V A A+GF+GG + P  F+G  LG
Sbjct: 307 LGITAPEPGGASILDFFGPAHYAWSWLWKLAFTVAALATGFKGGEVTPLFFIGAGLG 363


>UniRef50_B7FTG7 Predicted protein n=2 Tax=cellular organisms RepID=B7FTG7_PHATR
          Length = 588

 Score = 43.1 bits (100), Expect = 0.018,   Method: Compositional matrix adjust.
 Identities = 69/275 (25%), Positives = 113/275 (41%), Gaps = 43/275 (15%)

Query: 111 LAGGVSLGPEHPIMTVNIALAVA---IGARLLPRV---NRMEWTILASAGTIGALFGTPV 164
           L  G SLGPE P + + + +A +   I  R   R    NRM  +  A+AG + A F  P+
Sbjct: 220 LGTGCSLGPEGPCVEIGMDVARSCMDISRRTAERQRLWNRMLLSCGAAAG-VSAGFNAPI 278

Query: 165 AAAL--------IFSQTLNGSSEVP---------LWDRLFAP-LMAAAAGALTTGLFFHP 206
           A           +FS +++G              L     AP L+A+   AL        
Sbjct: 279 AGTFFALEIMHRMFS-SIDGEENADKDASAGLSSLNTATIAPVLIASVMSALCARTLLGD 337

Query: 207 HFSLPIAHYGQME----------MTDILSGAIVAAIAIAAGM-----VAVWCLPRLHAMM 251
           H  L +     ++          +  ++SG +  A + AA +     V  +   R    +
Sbjct: 338 HLVLALGGSYSLKKPLIELPLYMVLGLVSGTVSFAFSRAANLSQAVFVGDYGSDRFRMGV 397

Query: 252 HQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAA 311
             + +P     IGG + G++G I  P  LF G D +  ++AN +  T     L   K++ 
Sbjct: 398 RSL-SPAFKPVIGGILCGLVG-IKFPQILFFGYDCLNPLLANNSLPTPLLLSLLAAKISI 455

Query: 312 LVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAV 346
             ++A SG  GG   P++F+G   G   H  V ++
Sbjct: 456 TAISAGSGLVGGTFAPSLFLGAVTGAAFHNIVSSI 490


>UniRef50_C0YIY4 Chloride carrier/channel (ClC) family transporter n=3
           Tax=Bacteroidetes RepID=C0YIY4_9FLAO
          Length = 435

 Score = 42.7 bits (99), Expect = 0.027,   Method: Compositional matrix adjust.
 Identities = 82/334 (24%), Positives = 134/334 (40%), Gaps = 52/334 (15%)

Query: 34  ASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRF--SQGHAGP----DPAC 87
           A  LQ+L W      +   +++ LW+I  L + G  +GL+  +      AG     D   
Sbjct: 48  AGFLQSLEW------VTNFRENHLWLIAFLPVAGFLIGLLYYYFGKDVEAGNNLLIDTIH 101

Query: 88  EPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARL-LPRVNRME 146
           EP     +P    P + +  I     G S G E   + +  A+A  +     L R +R  
Sbjct: 102 EP--KGIIPFKMAPFVYLGTIATHFFGGSAGREGTALQMAGAIADQLTKPFKLDRNDRKV 159

Query: 147 WTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPL-----WDRLFAPLMAAAAGALTTG 201
             I A A   G++FGTP+A A+          EV L     ++ +F    +A    L T 
Sbjct: 160 LIISAIAAGFGSVFGTPLAGAVF-------GLEVFLIGRIRYNAIFPAFASAVLADLVTN 212

Query: 202 LFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPV--- 258
           L+   H    I    ++E   IL  +I+A IA   G+ A      +H M    K+ V   
Sbjct: 213 LWKVKHTHYHIDFVPKLEFLPILY-SILAGIAF--GICAAAFSKIIHWMGSFFKSKVKYP 269

Query: 259 --------LVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLA 310
                   +++ +  F +G    IG  + +     E Q  + + A           +K+ 
Sbjct: 270 PLRPVAGGIIIALAVFAMGTTRYIGLGIPMIMESFEKQLPLYDFA-----------LKMI 318

Query: 311 ALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVP 344
             +V  ++GF+GG + P  F+G  LG  L   +P
Sbjct: 319 FTIVTLSAGFKGGEVTPLFFIGATLGSALSLFIP 352


>UniRef50_A0NVL9 Cl-channel, voltage gated n=2 Tax=Alphaproteobacteria
           RepID=A0NVL9_9RHOB
          Length = 604

 Score = 42.7 bits (99), Expect = 0.027,   Method: Compositional matrix adjust.
 Identities = 92/372 (24%), Positives = 154/372 (41%), Gaps = 47/372 (12%)

Query: 4   PRARTMLLLSLP-----AVAIGIASSLILIVVMKIASVLQNLLWQRLPGTL----GIAQD 54
           P AR   + S+P     A  IGI +++  +    + S++ NL +     T+      A  
Sbjct: 18  PDARKERVFSVPLLCLVAFFIGIVAAIGAVFFRYLISIVHNLFYYGKFSTVYDANQFADP 77

Query: 55  SPL--WIIGVLTLTGIAVGLVIRF----SQGHAGPDPACEPLIGAPVPPSALPGLIVALI 108
           SPL   +I V  + G+ V  ++R     ++GH  P    E +         + G +VAL+
Sbjct: 78  SPLGALVILVPVIGGLIVVFLVRTFAPEAKGHGVP----EVMFAIYHKKGDVRG-VVALV 132

Query: 109 LGLAG------GVSLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFG 161
              A       G S+G E PI+ +  +    I   L LPR  ++      +   I A F 
Sbjct: 133 KSFASAISIGTGASVGREGPIIQIGASFGSTIARALHLPRWQKITLLSAGAGAGIAATFN 192

Query: 162 TPVAAALIFSQTLNGSSEVP-LWDRLFAPLMAAAAGALTTGLF---FHPHFSLPIAHYGQ 217
           TP+   L   + L     +P + +R F P++ A A A   G       P F +PI+    
Sbjct: 193 TPLGGVLFAVEML-----LPEVSNRTFLPVVVATATATYAGRIAFGLDPAFIVPISAEEA 247

Query: 218 MEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQM-----KNPVLVLGIGGFILGILG 272
           +E  + +     A + + AG VA W   R  A    +      N      IG  I+G L 
Sbjct: 248 IEAIEPIQLGAYALLGVLAG-VASWAFIRTLAWCEDLFPKLPGNDYTQNIIGMLIIGTLS 306

Query: 273 VI-----GGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFP 327
            +     G   +   G   +Q ++ +  ++     +L V K+ A  ++  +G  GG   P
Sbjct: 307 YVLMLTTGHYHTAGVGYATIQDILNSTPYTLILLAVLFVAKIIATSISLGAGASGGVFSP 366

Query: 328 AVFVGVALGLML 339
           ++F+G  LG M+
Sbjct: 367 SLFIGATLGGMV 378


>UniRef50_B7G9G8 Predicted protein n=1 Tax=Phaeodactylum tricornutum CCAP 1055/1
           RepID=B7G9G8_PHATR
          Length = 1260

 Score = 41.6 bits (96), Expect = 0.055,   Method: Compositional matrix adjust.
 Identities = 95/375 (25%), Positives = 151/375 (40%), Gaps = 63/375 (16%)

Query: 39  NLLWQRLPGTLGIAQDSP----LWI--IGVLTLTGIAVGL-VIRFSQGHAGPDP---ACE 88
           + LW  LP    I         LWI  IG     G+AVGL ++    G  G  P    C 
Sbjct: 113 DFLWHDLPERFVIDYWPEYLYVLWIPLIGF----GMAVGLGIVVKVMGEPGDLPYTVKCV 168

Query: 89  PLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARLLPRVNR---M 145
              G       +P ++ +    LAGG SLGPE P++ +  AL   +   +    +R    
Sbjct: 169 HEKGYVAMNHVMPMVMASQCSILAGG-SLGPEAPLVAICAALGGFVSRSVFGMTDRNLVR 227

Query: 146 EWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFH 205
           + T++  AG + A FG P+  +L F+  +N    +  ++     L A   G +   + F 
Sbjct: 228 KHTLMGMAGALAAFFGCPLGGSL-FAMEVNSRFGIEYFEH---TLEAILCGEICL-VVFR 282

Query: 206 PHFSLPIA-----HYGQMEMT---DILSGAIVAAIAIAAGMVAVWCLPRLH-AMMHQ--- 253
               LPI         ++E T   DIL G ++  +    G    W     H  +MH    
Sbjct: 283 ALAGLPIQAIWDISDDKLEATSVVDILYGCVLGLL----GAGVAWGFANFHWKVMHMFQH 338

Query: 254 ---MKNPVLV-LGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTS---------- 299
              +KN   +   + G ++ +L  +  P ++F G  E +  +A  A +            
Sbjct: 339 FNLLKNERAIHRAMAGAVVVVLMGMLVPQTMFWGEFEFE-TIATMAPTKDLMHIWPTSGL 397

Query: 300 -----DYF----LLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAI 350
                D F    ++ V KL A+    + G+RGG IFPA     ALG  +    P +P  +
Sbjct: 398 LGFEMDSFGSAMIVGVAKLIAISFTVSGGYRGGYIFPAFAAAAALGRAISILCPFIPVQL 457

Query: 351 TVSCAILGIVLVVTR 365
            V C    + + +TR
Sbjct: 458 CVLCMAAALNVALTR 472


>UniRef50_B8DDG6 Membrane protein, putative n=19 Tax=Listeria monocytogenes
           RepID=B8DDG6_LISMH
          Length = 420

 Score = 41.2 bits (95), Expect = 0.065,   Method: Compositional matrix adjust.
 Identities = 25/86 (29%), Positives = 48/86 (55%), Gaps = 2/86 (2%)

Query: 254 MKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVAN-QAFSTSDYFLLAVIKLAAL 312
           +KN ++   IGG  +G+ G+I   + LF G  ++ ++    Q +S     ++A++K   +
Sbjct: 268 IKNKMVAAVIGGLSIGLFGIISSFM-LFSGEHQLIELTTTVQNYSIPFLLIIALLKPVLV 326

Query: 313 VVAAASGFRGGRIFPAVFVGVALGLM 338
            +  A+G+ GG IFPA+F    +G +
Sbjct: 327 AICLATGWNGGAIFPAIFTSTIMGYI 352


Searching..................................................done


Results from round 2


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value
Sequences used in model and found again:

UniRef50_B5YZU3 Putative ion-transport protein yfeO n=97 Tax=Ent...   392   e-107
UniRef50_A4WD06 Cl-channel, voltage-gated family protein n=5 Tax...   348   2e-94
UniRef50_B5XVU7 Chloride transporter, chloride channel (ClC) fam...   325   2e-87
UniRef50_B0CCE6 Cl-channel, voltage gated n=3 Tax=Cyanobacteria ...   261   3e-68
UniRef50_Q8DIV5 Tlr1476 protein n=1 Tax=Thermosynechococcus elon...   257   5e-67
UniRef50_C6JBA2 Voltage-gated chloride channel family protein n=...   235   2e-60
UniRef50_Q0TTC6 Voltage-gated chloride channel family protein n=...   231   4e-59
UniRef50_Q3MBC4 Cl-channel, voltage gated n=7 Tax=Bacteria RepID...   228   2e-58
UniRef50_C3ATP4 Voltage-gated chloride channel n=9 Tax=Bacillus ...   221   3e-56
UniRef50_C2KWR2 Chloride carrier/channel (ClC) family transporte...   169   2e-40
UniRef50_C8XF05 Chloride channel core n=5 Tax=Actinomycetales Re...   150   7e-35
UniRef50_C1DC80 Probable voltage-gated chloride channel family p...   142   2e-32
UniRef50_B8C337 Chloride channel protein (Fragment) n=1 Tax=Thal...   137   9e-31
UniRef50_A3YZH8 Chloride channel-like protein n=1 Tax=Synechococ...   131   5e-29
UniRef50_O54193 Putative membrane protein n=3 Tax=Streptomyces R...   131   5e-29
UniRef50_B7G8L3 Predicted protein n=1 Tax=Phaeodactylum tricornu...   125   3e-27
UniRef50_D0R1Y7 Putative uncharacterized protein n=9 Tax=Lactoba...   109   3e-22

Sequences not found previously or not previously below threshold:

UniRef50_B7G9G8 Predicted protein n=1 Tax=Phaeodactylum tricornu...   179   1e-43
UniRef50_C4KYZ9 Chloride channel core n=1 Tax=Exiguobacterium sp...   141   5e-32
UniRef50_A0LDC4 Cl-channel, voltage-gated family protein n=1 Tax...   137   7e-31
UniRef50_C8WIS7 Chloride channel core n=2 Tax=Coriobacteriaceae ...   137   9e-31
UniRef50_C4ZAT1 Chloride channel protein EriC n=9 Tax=Bacteria R...   136   1e-30
UniRef50_Q64C69 Chloride channel n=1 Tax=uncultured archaeon GZf...   134   9e-30
UniRef50_C7R845 Chloride channel core n=1 Tax=Kangiella koreensi...   131   5e-29
UniRef50_B0G1X5 Putative uncharacterized protein n=1 Tax=Dorea f...   130   8e-29
UniRef50_D1JC90 Probable voltage gated chloride channel n=2 Tax=...   126   1e-27
UniRef50_B8DDG6 Membrane protein, putative n=19 Tax=Listeria mon...   126   2e-27
UniRef50_A6DFZ2 Chloride channel family protein n=1 Tax=Lentisph...   126   2e-27
UniRef50_Q3A443 Chloride channel protein EriC n=2 Tax=Desulfurom...   124   5e-27
UniRef50_C9R8B5 Cl-channel voltage-gated family protein n=2 Tax=...   121   4e-26
UniRef50_C1F0W1 Chloride transporter, ClC family n=1 Tax=Acidoba...   121   5e-26
UniRef50_A4GJ08 Putative CBS:IMP dehydrogenase/GMP reductase:vol...   118   3e-25
UniRef50_UPI0001972FFA chloride channel protein EriC n=1 Tax=Clo...   118   3e-25
UniRef50_Q1N3I5 Chloride channel, putative n=1 Tax=Bermanella ma...   117   6e-25
UniRef50_Q8RXR2 Chloride channel protein CLC-f n=18 Tax=Magnolio...   117   9e-25
UniRef50_B4CXW5 Chloride channel core n=1 Tax=Chthoniobacter fla...   116   2e-24
UniRef50_B8HWS8 Chloride channel core n=6 Tax=Bacteria RepID=B8H...   115   3e-24
UniRef50_Q04PD3 Chloride channel protein n=4 Tax=Leptospira RepI...   115   3e-24
UniRef50_Q8GX93 Chloride channel protein CLC-e n=7 Tax=Magnoliop...   115   3e-24
UniRef50_C6C168 Chloride channel core n=1 Tax=Desulfovibrio sale...   114   5e-24
UniRef50_C0QAG4 EriC1 n=1 Tax=Desulfobacterium autotrophicum HRM...   114   6e-24
UniRef50_A3CW01 Cl-channel, voltage-gated family protein n=3 Tax...   114   6e-24
UniRef50_C1MEP8 Voltage-gated chloride channel family protein n=...   114   7e-24
UniRef50_Q3M8F4 Cl-channel, voltage gated n=3 Tax=Cyanobacteria ...   114   8e-24
UniRef50_A7BCR6 Putative uncharacterized protein n=1 Tax=Actinom...   114   9e-24
UniRef50_B9XDX3 Chloride channel core n=1 Tax=bacterium Ellin514...   113   1e-23
UniRef50_Q6AIP2 Related to chloride channel protein n=1 Tax=Desu...   113   1e-23
UniRef50_Q316N5 CBS n=1 Tax=Desulfovibrio desulfuricans subsp. d...   113   1e-23
UniRef50_A0B965 Cl-channel, voltage-gated family protein n=3 Tax...   112   2e-23
UniRef50_C4G8P2 Putative uncharacterized protein n=1 Tax=Shuttle...   112   2e-23
UniRef50_B2V3B5 Voltage gated chloride channel family n=9 Tax=Cl...   112   2e-23
UniRef50_D1PN62 Chloride transporter, chloride channel family n=...   112   3e-23
UniRef50_Q1DG09 Chloride transporter, chloride channel (ClC) fam...   112   3e-23
UniRef50_A8SIK8 Putative uncharacterized protein n=1 Tax=Parvimo...   112   3e-23
UniRef50_A8UVV7 tRNA (Uracil-5-)-methyltransferase Gid n=3 Tax=A...   112   3e-23
UniRef50_A6P174 Putative uncharacterized protein n=1 Tax=Bactero...   111   4e-23
UniRef50_C7PDX9 Chloride channel core n=3 Tax=Bacteria RepID=C7P...   111   4e-23
UniRef50_B9L7R0 Voltage-gated chloride channel n=2 Tax=Nautiliac...   111   5e-23
UniRef50_B7FTG7 Predicted protein n=2 Tax=cellular organisms Rep...   111   5e-23
UniRef50_A8TQW2 Cl-channel, voltage-gated family protein n=1 Tax...   111   6e-23
UniRef50_A8ZW16 Chloride channel core n=1 Tax=Desulfococcus oleo...   111   6e-23
UniRef50_C0YIY4 Chloride carrier/channel (ClC) family transporte...   111   8e-23
UniRef50_C4Z1M2 Chloride channel protein, CIC family n=1 Tax=Eub...   110   1e-22
UniRef50_Q31NT2 Chloride channel-like n=2 Tax=Synechococcus elon...   109   1e-22
UniRef50_C1TRX3 Chloride channel protein EriC n=3 Tax=Synergista...   109   1e-22
UniRef50_C5NXG2 H(+)/Cl(-) exchange transporter ClcA n=1 Tax=Gem...   109   1e-22
UniRef50_B2IWH4 Cl-channel, voltage-gated family protein n=2 Tax...   109   2e-22
UniRef50_C8X3C6 Cl-channel voltage-gated family protein n=1 Tax=...   109   2e-22
UniRef50_C6W519 Chloride channel core n=1 Tax=Dyadobacter fermen...   109   3e-22
UniRef50_B8FBB1 Chloride channel core n=1 Tax=Desulfatibacillum ...   109   3e-22
UniRef50_A4BAH0 Chloride channel protein EriC n=1 Tax=Reinekea b...   109   3e-22
UniRef50_A2BJY0 Voltage-gated chloride channel protein n=1 Tax=H...   109   3e-22
UniRef50_A9A065 Chloride channel core n=1 Tax=Desulfococcus oleo...   109   3e-22
UniRef50_Q7NS08 Probable voltage-gated chloride channel family p...   108   4e-22
UniRef50_Q0TP43 Voltage-gated chloride channel family protein n=...   108   4e-22
UniRef50_B0SCJ7 Chloride channel protein n=2 Tax=Leptospira bifl...   108   5e-22
UniRef50_C8WVL6 Cl-channel voltage-gated family protein n=1 Tax=...   108   5e-22
UniRef50_Q12WA6 Voltage-gated ClC-type chloride channel n=5 Tax=...   107   6e-22
UniRef50_B5CM99 Putative uncharacterized protein n=1 Tax=Ruminoc...   107   9e-22
UniRef50_A5UNZ8 Voltage gated chloride channel protein/cation tr...   107   1e-21
UniRef50_Q0BQZ9 Chloride channel protein n=4 Tax=Acetobacteracea...   107   1e-21
UniRef50_A7HVW3 Chloride channel core n=1 Tax=Parvibaculum lavam...   106   1e-21
UniRef50_Q39PZ5 Cl-channel, voltage gated n=4 Tax=Desulfuromonad...   106   1e-21
UniRef50_B2UN00 Chloride channel core n=1 Tax=Akkermansia mucini...   106   1e-21
UniRef50_B3PL72 Voltage-gated chloride channel n=1 Tax=Cellvibri...   106   2e-21
UniRef50_Q02Z91 Chloride channel protein EriC n=4 Tax=Lactococcu...   106   2e-21
UniRef50_B2KDW6 Chloride channel core n=1 Tax=Elusimicrobium min...   106   2e-21
UniRef50_A0NVL9 Cl-channel, voltage gated n=2 Tax=Alphaproteobac...   106   2e-21
UniRef50_A0NVM0 Cl-channel, voltage gated n=4 Tax=Alphaproteobac...   106   2e-21
UniRef50_C9LB15 Voltage-gated chloride channel family protein n=...   106   2e-21
UniRef50_C5BP50 Chloride transporter, ClC family n=1 Tax=Teredin...   106   2e-21
UniRef50_C3WBQ0 Chloride channel protein n=1 Tax=Fusobacterium m...   106   2e-21
UniRef50_A3DHF3 Cl-channel, voltage gated n=5 Tax=Clostridium Re...   106   3e-21
UniRef50_A6BDR3 Putative uncharacterized protein n=1 Tax=Dorea l...   105   3e-21
UniRef50_C5EV85 Chloride ion channel protein n=6 Tax=Clostridial...   105   3e-21
UniRef50_A4YDN2 Cl-channel, voltage-gated family protein n=19 Ta...   105   3e-21
UniRef50_D0MHJ3 Chloride channel core n=1 Tax=Rhodothermus marin...   105   4e-21
UniRef50_A2ZX03 Putative uncharacterized protein n=2 Tax=Oryza s...   105   4e-21
UniRef50_C1SJ13 Chloride channel protein EriC n=1 Tax=Denitrovib...   104   5e-21
UniRef50_A3HUV6 Putative transport related, membrane protein n=1...   104   5e-21
UniRef50_Q020M6 Cl-channel, voltage-gated family protein n=2 Tax...   104   5e-21
UniRef50_D1W6U8 Chloride transporter, ClC family n=16 Tax=Bacter...   104   6e-21
UniRef50_C7NEM7 Chloride channel core n=3 Tax=Leptotrichia RepID...   104   7e-21
UniRef50_Q21MI5 Cl-channel, voltage gated n=1 Tax=Saccharophagus...   104   7e-21
UniRef50_A5EFE0 CLC-type chloride channel protein n=3 Tax=Bradyr...   104   7e-21
UniRef50_B5FF64 Chloride channel protein n=4 Tax=Bacteria RepID=...   104   8e-21
UniRef50_Q1GIU0 Cl-channel voltage gated n=37 Tax=Rhodobacterale...   104   8e-21
UniRef50_D2BKV3 Chloride channel protein n=4 Tax=Lactococcus lac...   104   9e-21
UniRef50_B2UP88 Chloride channel core n=1 Tax=Akkermansia mucini...   104   1e-20
UniRef50_Q1K0X2 Cl-channel, voltage gated n=1 Tax=Desulfuromonas...   103   1e-20
UniRef50_C6BS05 Chloride channel core n=1 Tax=Desulfovibrio sale...   103   1e-20
UniRef50_A0LQV7 Cl-channel, voltage-gated family protein n=1 Tax...   103   1e-20
UniRef50_B9XGZ2 Chloride channel core n=3 Tax=Verrucomicrobia Re...   103   1e-20
UniRef50_A5N0V4 ClcA n=2 Tax=Clostridium kluyveri RepID=A5N0V4_C...   103   2e-20
UniRef50_A3EVY7 Putative Cl-channel, voltage gated n=2 Tax=Lepto...   102   2e-20
UniRef50_B6YRP1 Voltage-gated ClC-type chloride channel n=33 Tax...   102   2e-20
UniRef50_A6CC67 Putative chloride channel n=2 Tax=Planctomycetac...   102   3e-20
UniRef50_A6TUH7 Chloride channel, core n=2 Tax=Firmicutes RepID=...   102   3e-20
UniRef50_B0SCW6 Chloride channel protein n=2 Tax=Leptospira bifl...   101   4e-20
UniRef50_C4G1J1 Putative uncharacterized protein n=1 Tax=Abiotro...   101   4e-20
UniRef50_D1XZY9 Chloride transporter, ClC family n=2 Tax=Prevote...   101   4e-20
UniRef50_A9BT15 Chloride channel core n=9 Tax=Bacteria RepID=A9B...   101   5e-20
UniRef50_Q6SGK9 Voltage-gated chloride channel n=4 Tax=Bacteria ...   101   5e-20
UniRef50_A5VU61 Voltage gated chloride channel family protein n=...   101   6e-20
UniRef50_D0LKI3 Cl-channel voltage-gated family protein n=1 Tax=...   101   6e-20
UniRef50_Q1CYU1 Voltage-gated chloride channel n=2 Tax=Cystobact...   100   7e-20
UniRef50_B5YBN2 SycA n=1 Tax=Dictyoglomus thermophilum H-6-12 Re...   100   8e-20
UniRef50_B5ILG4 Cl-channel, voltage gated n=1 Tax=Cyanobium sp. ...   100   8e-20
UniRef50_A6Q6W6 Voltage-gated chloride channel n=4 Tax=Epsilonpr...   100   1e-19
UniRef50_B7CDF1 Putative uncharacterized protein n=1 Tax=Eubacte...   100   1e-19
UniRef50_Q701W5 Putative chloride channel protein n=1 Tax=uncult...   100   1e-19
UniRef50_UPI000196B5DC hypothetical protein CATMIT_00127 n=1 Tax...   100   1e-19
UniRef50_B8FFG6 Chloride channel core n=2 Tax=Desulfobacteraceae...   100   1e-19
UniRef50_B2A6J0 Chloride channel core n=1 Tax=Natranaerobius the...   100   2e-19
UniRef50_A5TVM5 CIC chloride ion channel family chloride (Cl-):p...   100   2e-19
UniRef50_B2TNJ2 Voltage-gated chloride channel n=19 Tax=Firmicut...   100   2e-19
UniRef50_A8I3C7 Voltage gated chloride channel family protein n=...    99   2e-19
UniRef50_C7QDN8 Chloride channel core n=3 Tax=Actinomycetales Re...    99   2e-19
UniRef50_D1U7C4 Chloride channel core n=2 Tax=Desulfovibrio RepI...    99   2e-19
UniRef50_UPI0001C31F65 Cl- channel voltage-gated family protein ...    99   2e-19
UniRef50_D1RX40 Chloride channel protein n=1 Tax=Serratia odorif...    99   3e-19
UniRef50_C7M702 Chloride channel core n=15 Tax=Bacteroidetes Rep...    99   3e-19
UniRef50_C0QQU7 Chloride channel protein n=1 Tax=Persephonella m...    99   3e-19
UniRef50_Q73KN8 Voltage-gated chloride channel n=2 Tax=Treponema...    99   3e-19
UniRef50_A5FBK4 Cl-channel, voltage-gated family protein n=4 Tax...    99   3e-19
UniRef50_Q1MXQ9 Chloride channel protein EriC n=1 Tax=Bermanella...    99   3e-19
UniRef50_D2QXG0 Chloride channel core n=1 Tax=Pirellula staleyi ...    99   4e-19
UniRef50_B2HXI5 Chloride channel protein EriC n=11 Tax=Acinetoba...    98   4e-19
UniRef50_UPI0001BC5534 chloride channel protein n=3 Tax=Fusobact...    98   5e-19
UniRef50_B0MW79 Putative uncharacterized protein n=1 Tax=Alistip...    98   6e-19
UniRef50_D1AXX8 Chloride channel core n=1 Tax=Streptobacillus mo...    98   6e-19
UniRef50_C8X5N8 Cl-channel voltage-gated family protein n=1 Tax=...    98   7e-19
UniRef50_Q189E6 Chloride ion channel protein n=10 Tax=Bacteria R...    98   7e-19
UniRef50_D2QHH8 Cl-channel voltage-gated family protein n=1 Tax=...    98   9e-19
UniRef50_Q1IME9 Cl-channel, voltage gated n=1 Tax=Candidatus Kor...    98   9e-19
UniRef50_UPI0001C418FE voltage-gated chloride channel protein n=...    97   1e-18
UniRef50_C7PH71 Chloride channel core n=2 Tax=Bacteroidetes RepI...    97   1e-18
UniRef50_A3CXC7 Chloride channel protein EriC-like protein n=1 T...    97   1e-18
UniRef50_A1AU45 Cl-channel, voltage-gated family protein n=5 Tax...    96   2e-18
UniRef50_B1Z0X2 Chloride channel core n=79 Tax=Bacteria RepID=B1...    96   2e-18
UniRef50_B2J2P8 Cl-channel, voltage-gated family protein n=3 Tax...    96   2e-18
UniRef50_Q2BHE2 Cl-channel, voltage gated n=1 Tax=Neptuniibacter...    96   2e-18
UniRef50_D0KW58 Cl-channel voltage-gated family protein n=1 Tax=...    96   2e-18
UniRef50_Q3AQR7 Chloride channel, putative n=12 Tax=Chlorobiacea...    96   3e-18
UniRef50_A3ZLX7 Chloride channel protein n=1 Tax=Blastopirellula...    96   3e-18
UniRef50_B3Q6A2 Chloride channel core n=4 Tax=Rhodopseudomonas p...    96   3e-18
UniRef50_C2GZL1 Voltage-gated chloride channel family protein n=...    96   3e-18
UniRef50_C1SIP9 Chloride channel protein EriC n=1 Tax=Denitrovib...    96   3e-18
UniRef50_B8DM62 Chloride channel core n=3 Tax=Desulfovibrionales...    95   4e-18
UniRef50_A6TWM3 Chloride channel, core n=1 Tax=Alkaliphilus meta...    95   4e-18
UniRef50_C9KMS0 Voltage-gated chloride channel family protein n=...    95   4e-18
UniRef50_C1F836 Chloride transporter, ClC family n=1 Tax=Acidoba...    95   4e-18
UniRef50_Q892T8 Chloride channel protein n=1 Tax=Clostridium tet...    95   5e-18
UniRef50_A3NY48 Chloride transporter, chloride channel (ClC) fam...    95   5e-18
UniRef50_C0W1S0 H(+)/Cl(-) exchange transporter n=1 Tax=Actinomy...    95   5e-18
UniRef50_Q15SM8 Cl-channel, voltage gated n=1 Tax=Pseudoalteromo...    95   6e-18
UniRef50_B5EQW9 Chloride channel core n=2 Tax=Acidithiobacillus ...    94   6e-18
UniRef50_D1AKC6 Chloride channel core n=2 Tax=Fusobacteriaceae R...    94   7e-18
UniRef50_Q1YV59 Voltage-gated chloride channel family protein n=...    94   7e-18
UniRef50_Q57753 Uncharacterized protein MJ0305 n=5 Tax=Methanoca...    94   7e-18
UniRef50_UPI000174564F putative voltage-gated ClC-type chloride ...    94   8e-18
UniRef50_A4E742 Putative uncharacterized protein n=3 Tax=Collins...    94   8e-18
UniRef50_Q0TQI9 Voltage-gated chloride channel family protein n=...    94   9e-18
UniRef50_C6JKX7 Chloride channel protein n=5 Tax=Fusobacterium R...    94   9e-18
UniRef50_B5JKG4 Chloride transporter, ClC family, putative n=1 T...    94   9e-18
UniRef50_Q0EW01 Cl-channel, voltage gated n=1 Tax=Mariprofundus ...    94   1e-17
UniRef50_D1CB35 Chloride channel core n=6 Tax=Bacteria RepID=D1C...    94   1e-17
UniRef50_C9RMG0 Cl-channel voltage-gated family protein n=1 Tax=...    94   1e-17
UniRef50_B1ZT36 Chloride channel core n=1 Tax=Opitutus terrae PB...    94   1e-17
UniRef50_C1F1A6 Chloride transporter, ClC family n=1 Tax=Acidoba...    94   1e-17
UniRef50_C7H8M0 Voltage-gated chloride channel family protein n=...    94   1e-17
UniRef50_C3X6F3 Chloride channel protein n=2 Tax=Oxalobacter for...    94   1e-17
UniRef50_A2BL36 Conserved archaeal protein n=1 Tax=Hyperthermus ...    94   1e-17
UniRef50_B9GHY7 Cl-channel clc-3 n=5 Tax=Magnoliophyta RepID=B9G...    93   1e-17
UniRef50_Q2JJR6 Chloride transporter, chloride channel family n=...    93   1e-17
UniRef50_C5VMQ7 Putative chloride channel n=1 Tax=Prevotella mel...    93   1e-17
UniRef50_A5FTY4 CBS domain containing protein n=15 Tax=Bacteria ...    93   2e-17
UniRef50_C5A3X3 Voltage-gated ClC-type chloride channel n=6 Tax=...    93   2e-17
UniRef50_UPI0001C33F57 chloride channel protein n=2 Tax=Enteroba...    93   2e-17
UniRef50_Q03UF5 Chloride channel protein EriC n=4 Tax=Leuconosto...    93   2e-17
UniRef50_C6XZM8 Chloride channel core n=3 Tax=Sphingobacteriacea...    93   2e-17
UniRef50_Q3AWV3 Possible chloride channel n=12 Tax=Synechococcus...    93   3e-17
UniRef50_B2VDE2 Cl-channel, voltage gated n=4 Tax=Enterobacteria...    93   3e-17
UniRef50_Q040F7 Chloride channel protein EriC n=29 Tax=Lactobaci...    93   3e-17
UniRef50_B5ZIM0 Chloride channel core n=11 Tax=Acetobacteraceae ...    92   3e-17
UniRef50_A9CJ03 Chloride channel protein n=2 Tax=Rhizobium/Agrob...    92   3e-17
UniRef50_C6HUP8 Putative Cl-channel, voltage gated n=1 Tax=Lepto...    92   4e-17
UniRef50_A0LKT1 Cl-channel, voltage-gated family protein n=1 Tax...    92   4e-17
UniRef50_B8H095 Chloride channel protein n=15 Tax=Proteobacteria...    92   4e-17
UniRef50_C0M694 Voltage gated chloride channel protein n=5 Tax=F...    92   4e-17
UniRef50_Q2JA24 Cl-channel, voltage gated n=4 Tax=Actinomycetale...    92   5e-17
UniRef50_Q1LQV6 Cl-channel, voltage gated n=66 Tax=Proteobacteri...    91   5e-17
UniRef50_C6X6C8 Chloride channel protein n=2 Tax=Flavobacteriace...    91   5e-17
UniRef50_Q72EW7 Chloride channel family protein n=6 Tax=Desulfov...    91   5e-17
UniRef50_C5PV52 Chloride channel protein n=1 Tax=Sphingobacteriu...    91   6e-17
UniRef50_Q0ABK0 Cl-channel, voltage-gated family protein n=1 Tax...    91   6e-17
UniRef50_C6P622 Chloride channel core n=1 Tax=Sideroxydans litho...    91   7e-17
UniRef50_Q8XTT4 Putative chloride channel protein clcB-like n=62...    91   7e-17
UniRef50_Q1QSB4 Cl-channel, voltage gated n=1 Tax=Chromohalobact...    91   7e-17
UniRef50_C0R0D3 Puttaive chloride channel protein n=2 Tax=Brachy...    91   8e-17
UniRef50_B1C8T2 Putative uncharacterized protein n=2 Tax=Clostri...    91   8e-17
UniRef50_C1ZCM5 Chloride channel protein EriC n=1 Tax=Planctomyc...    91   8e-17
UniRef50_C6PDT2 Chloride channel core n=1 Tax=Thermoanaerobacter...    91   8e-17
UniRef50_D0BMA2 Voltage-gated chloride channel protein n=1 Tax=G...    91   1e-16
UniRef50_D1NB42 Cl-channel voltage-gated family protein n=1 Tax=...    91   1e-16
UniRef50_C0RHJ6 Chloride channel core protein n=2 Tax=Brucella m...    90   2e-16
UniRef50_B6JH96 Voltage-gated chloride channel n=1 Tax=Oligotrop...    89   2e-16
UniRef50_Q3DFX6 Voltage-gated chloride channel family protein n=...    89   2e-16
UniRef50_C8WC17 Chloride channel core n=5 Tax=Proteobacteria Rep...    89   2e-16
UniRef50_B5ZGR7 Chloride channel core n=11 Tax=Bacteria RepID=B5...    89   2e-16
UniRef50_C8WAP8 Chloride channel core n=2 Tax=Atopobium RepID=C8...    89   3e-16
UniRef50_D2UEG8 Probable chloride channel protein n=1 Tax=Xantho...    89   3e-16
UniRef50_B0R5U8 Chloride channel n=2 Tax=Halobacterium salinarum...    89   3e-16
UniRef50_D1NS75 Chloride transporter, chloride channel family n=...    89   3e-16
UniRef50_A5G2G7 Cl-channel, voltage-gated family protein n=1 Tax...    89   3e-16
UniRef50_Q2S8Y1 Chloride channel protein EriC n=4 Tax=Gammaprote...    89   3e-16
UniRef50_C1EDM4 Chloride Carrier/Channel family n=1 Tax=Micromon...    89   3e-16
UniRef50_B0S0E6 Chloride channel protein n=2 Tax=Finegoldia magn...    89   3e-16
UniRef50_C5VYM9 Voltage gated chloride channel protein n=5 Tax=S...    89   4e-16
UniRef50_A5TYL8 Chloride channel n=18 Tax=Actinobacteria (class)...    88   4e-16
UniRef50_D0BLG2 Voltage-gated chloride channel protein n=1 Tax=G...    88   4e-16
UniRef50_UPI0001B54CF5 hypothetical protein StreC_17202 n=1 Tax=...    88   5e-16
UniRef50_Q11QF8 Chloride channel protein n=1 Tax=Cytophaga hutch...    88   5e-16
UniRef50_B9Z495 Chloride channel core protein n=1 Tax=Lutiella n...    88   6e-16
UniRef50_Q475N5 CBS:Cl-channel, voltage gated n=4 Tax=Cupriavidu...    88   6e-16
UniRef50_C2HCF1 Chloride carrier/channel (ClC) family transporte...    88   6e-16
UniRef50_Q03KD5 Chloride channel protein EriC n=13 Tax=Firmicute...    88   7e-16
UniRef50_Q1JHR4 Chloride channel protein n=25 Tax=Firmicutes Rep...    88   7e-16
UniRef50_B1LX30 Chloride channel core n=18 Tax=Alphaproteobacter...    88   8e-16
UniRef50_C0YZT6 Voltage-gated chloride channel family protein n=...    88   8e-16

>UniRef50_B5YZU3 Putative ion-transport protein yfeO n=97 Tax=Enterobacteriaceae
           RepID=YFEO_ECO5E
          Length = 418

 Score =  392 bits (1007), Expect = e-107,   Method: Composition-based stats.
 Identities = 418/418 (100%), Positives = 418/418 (100%)

Query: 1   MLHPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWII 60
           MLHPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWII
Sbjct: 1   MLHPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWII 60

Query: 61  GVLTLTGIAVGLVIRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPE 120
           GVLTLTGIAVGLVIRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPE
Sbjct: 61  GVLTLTGIAVGLVIRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPE 120

Query: 121 HPIMTVNIALAVAIGARLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEV 180
           HPIMTVNIALAVAIGARLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEV
Sbjct: 121 HPIMTVNIALAVAIGARLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEV 180

Query: 181 PLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVA 240
           PLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVA
Sbjct: 181 PLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVA 240

Query: 241 VWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSD 300
           VWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSD
Sbjct: 241 VWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSD 300

Query: 301 YFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIV 360
           YFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIV
Sbjct: 301 YFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIV 360

Query: 361 LVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNRPKQQPPHDNV 418
           LVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNRPKQQPPHDNV
Sbjct: 361 LVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNRPKQQPPHDNV 418


>UniRef50_A4WD06 Cl-channel, voltage-gated family protein n=5 Tax=Bacteria
           RepID=A4WD06_ENT38
          Length = 411

 Score =  348 bits (893), Expect = 2e-94,   Method: Composition-based stats.
 Identities = 329/411 (80%), Positives = 366/411 (89%)

Query: 1   MLHPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWII 60
           MLHPRA+TMLLL+ PA+ IGIASSL+LIVVMK+ASVLQ  LW  LPG LGI   SP WII
Sbjct: 1   MLHPRAKTMLLLATPALIIGIASSLVLIVVMKVASVLQAFLWTALPGKLGIDFASPTWII 60

Query: 61  GVLTLTGIAVGLVIRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPE 120
            +LTLTGI VGLVIRFS GHAGPDPA EPLI APV P+ALPGL++ALI+GLAGGVSLGPE
Sbjct: 61  LMLTLTGITVGLVIRFSPGHAGPDPALEPLISAPVNPAALPGLLLALIIGLAGGVSLGPE 120

Query: 121 HPIMTVNIALAVAIGARLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEV 180
           HPIM VNIALAV +G+R+ PRV  ++WTILASAGTIGALFGTPVAAALIFSQTL+G ++V
Sbjct: 121 HPIMAVNIALAVYLGSRIFPRVGALDWTILASAGTIGALFGTPVAAALIFSQTLSGDNDV 180

Query: 181 PLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVA 240
           PLWDRLFAPLMAAAAGALTT LF+HPHFSLPI HYGQM++ DI SGAIVAAIAIA GMVA
Sbjct: 181 PLWDRLFAPLMAAAAGALTTSLFYHPHFSLPIPHYGQMQLADIFSGAIVAAIAIALGMVA 240

Query: 241 VWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSD 300
           VWCLPRLH +MH++K+ VL+LG GGF+LGILG IGGPV+LFKGLDEMQQM  +Q FS SD
Sbjct: 241 VWCLPRLHRLMHKLKHSVLILGAGGFLLGILGAIGGPVTLFKGLDEMQQMAFSQVFSVSD 300

Query: 301 YFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIV 360
           YFL AVIKLAA+VVAAA GFRGGRIFPAVF+GVALGLMLHEHV AVPAAIT+SC+ILG+V
Sbjct: 301 YFLFAVIKLAAVVVAAACGFRGGRIFPAVFIGVALGLMLHEHVDAVPAAITISCSILGLV 360

Query: 361 LVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNRPKQ 411
           LVVTRD WLSLFMAAVVVP+T LLPLLCIVMLPAWLLLAGKPM+M  R  +
Sbjct: 361 LVVTRDAWLSLFMAAVVVPDTNLLPLLCIVMLPAWLLLAGKPMLMAWRQNK 411


>UniRef50_B5XVU7 Chloride transporter, chloride channel (ClC) family n=18
           Tax=Bacteria RepID=B5XVU7_KLEP3
          Length = 411

 Score =  325 bits (834), Expect = 2e-87,   Method: Composition-based stats.
 Identities = 316/409 (77%), Positives = 364/409 (88%)

Query: 1   MLHPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWII 60
           MLHPRARTML+LS+PA+ IGIA SLILI  MK+A++LQ +LW  LP  LGI+ DSPLWII
Sbjct: 1   MLHPRARTMLILSVPAILIGIACSLILIGAMKVAALLQRVLWSNLPTQLGISADSPLWII 60

Query: 61  GVLTLTGIAVGLVIRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPE 120
            +LT TGIAVGLV+R+S GHAGPDPA E LIGAP+   ALPGL+ ALILGLAGGVSLGPE
Sbjct: 61  AMLTATGIAVGLVVRYSPGHAGPDPATESLIGAPIATGALPGLLAALILGLAGGVSLGPE 120

Query: 121 HPIMTVNIALAVAIGARLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEV 180
           HPIM VNIALAVA+G+RL PRV+ ++WTILA++GTIGALFGTPVAAALIFSQTLN S+E 
Sbjct: 121 HPIMVVNIALAVAVGSRLFPRVSSLDWTILAASGTIGALFGTPVAAALIFSQTLNSSNES 180

Query: 181 PLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVA 240
           PLWDRLFAPL+AAAAGALTTGLFFHPHF+LPI HYGQM   DI+SG IVA IAIA GMVA
Sbjct: 181 PLWDRLFAPLLAAAAGALTTGLFFHPHFTLPIPHYGQMHFVDIISGMIVALIAIAVGMVA 240

Query: 241 VWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSD 300
           VWCLPRLHA+MH++++P+L LGIGG +LGILG IGGP++LFKGLDEMQQ+  +Q  + +D
Sbjct: 241 VWCLPRLHALMHRLRHPILTLGIGGLLLGILGTIGGPLTLFKGLDEMQQLAFSQTLTAAD 300

Query: 301 YFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIV 360
           + L+A++KLAALV+A+ASGFRGGRIFPAVFVGVALGLMLH HV AVPAAITVSCAILG+V
Sbjct: 301 FLLIALVKLAALVLASASGFRGGRIFPAVFVGVALGLMLHAHVDAVPAAITVSCAILGMV 360

Query: 361 LVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNRP 409
           LVVTRDGWLSLFMAAVVVP+TTLLPLLCIVMLPAWLLLAG+P+M+  R 
Sbjct: 361 LVVTRDGWLSLFMAAVVVPDTTLLPLLCIVMLPAWLLLAGRPLMIAKRT 409


>UniRef50_B0CCE6 Cl-channel, voltage gated n=3 Tax=Cyanobacteria RepID=B0CCE6_ACAM1
          Length = 465

 Score =  261 bits (667), Expect = 3e-68,   Method: Composition-based stats.
 Identities = 97/424 (22%), Positives = 181/424 (42%), Gaps = 27/424 (6%)

Query: 5   RARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTL------GIAQDSPLW 58
           R  T   L + A  IG+   L+      +   L + +W  +P  +       + Q   +W
Sbjct: 24  RELTYSQLVICAALIGVFGGLVATAYYFVLETLMHGVWHTVPDRVVPYFPSWLPQQHYVW 83

Query: 59  IIGVLTLTGIAVGLVIRFSQGHAGPDPACEPLIGAP--VPPSALPGLIVALILGLAGGVS 116
           I    T+ G  VGLV+ F  G  G        I +P  +     P +I+A ++ +  G S
Sbjct: 84  IAS--TIGGFCVGLVLFFM-GLPGEMAQVVDKIHSPGKIDIRKTPAMIIASLVAITSGGS 140

Query: 117 LGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLN 175
            GPE P++ VN +    +G +L L   +    T    +  +GA FG P+ AAL   +  +
Sbjct: 141 AGPEAPLVQVNGSFGSWLGEKLQLTTTSVRVLTFCGMSAALGAFFGAPIGAALFALEIPH 200

Query: 176 GSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILS------GAIV 229
                      +  +  A   A+ +   F  +  + I  +   E    L+      G ++
Sbjct: 201 RK-----GLEYYEAIAPAVVSAIFSFAVFRINTGMTIGGFYHFETVPPLTPTNLLEGLVL 255

Query: 230 AAIAIAAGMVAVWCLPRL-HAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQ 288
             I     ++ +     + H +     + +L+  +GG  +G++  +  P +LF   +++ 
Sbjct: 256 GGIGAGVAVMFIGVFRLVGHLLAPLEHHRILLATLGGLTIGLIA-LAFPQTLFFSEEQIH 314

Query: 289 QMVANQAFSTSDYFLL-AVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVP 347
            ++   A     + L+ AV K+ A+ V   SGF GG IFP  F+G  +GL +   VP V 
Sbjct: 315 TVIETGATLGITFLLMIAVAKMFAISVTLHSGFLGGFIFPLFFIGANVGLAISLMVPQVH 374

Query: 348 AAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVN 407
             + + C +  + + VT+   +S  +   V+    +LP++ I    ++LL +   M+   
Sbjct: 375 PTLGMVCLMAAVNVAVTKTP-VSTSIILSVLSGMAMLPVIVISSFVSFLLTSQIAMIKTQ 433

Query: 408 RPKQ 411
           R ++
Sbjct: 434 RSRE 437


>UniRef50_Q8DIV5 Tlr1476 protein n=1 Tax=Thermosynechococcus elongatus BP-1
           RepID=Q8DIV5_THEEB
          Length = 420

 Score =  257 bits (657), Expect = 5e-67,   Method: Composition-based stats.
 Identities = 111/418 (26%), Positives = 193/418 (46%), Gaps = 17/418 (4%)

Query: 9   MLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWI--IGVLTLT 66
              L L A+ IG+ S  +         +   LLW   P  + IA    L+     V    
Sbjct: 8   YPRLLLYALIIGLLSGCVTTAFYLGLKLGFALLWGTDPSQVSIATWEHLYPYIPLVTAFG 67

Query: 67  GIAVGLVIRFSQGHAGP--DPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIM 124
           G+ VGL ++F  G  G   D   E   G  +    LPG+ +A  L L  G S GPE P++
Sbjct: 68  GLLVGLSVKF-FGAKGELADAIAELHHGGRLSYRFLPGMALASGLSLLFGSSAGPESPMI 126

Query: 125 TVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLW 183
            +N  L   + ARL L   +    T+   A  +   F +P+  A +F   +     V  +
Sbjct: 127 DINGGLGTWLAARLNLSPASTRILTLCGMAAGMSVFFESPL-GATLFVLEIPHRRSVEFY 185

Query: 184 DRLFAPLMAAAAGA----LTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMV 239
           + +   L++AAAG     + TG      +  P   Y  +   DI    ++  I  A G +
Sbjct: 186 EAIIPALISAAAGFTLFRVITGTTIGAIYRFPT--YDSLRPQDIGFAVLLGFIGAAVGTL 243

Query: 240 AVWCLPRLHAMMHQMKN-PVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVAN-QAFS 297
            V+   ++   +   +  P+L++ + GF++G++ +I  P++LF G  +++Q++     +S
Sbjct: 244 FVFLDRQIQRWLTPYRQYPLLLIVVVGFLIGVIALI-HPITLFYGERQIEQVIEVVNRYS 302

Query: 298 TSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAIL 357
                 +A  KL AL +    GFRGG +FP  FVG  +G+ +H+ +P  P ++ ++  + 
Sbjct: 303 IGILLRVAFFKLLALSLCLRGGFRGGVVFPLFFVGACVGMAVHQALPNTPLSVALAGMMA 362

Query: 358 GIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNRPKQQPPH 415
            + +VVT+   L L +   V+ +T +LPL+ I  L ++LL      +   R ++  P 
Sbjct: 363 AVTVVVTKTP-LGLAIILTVISHTAMLPLMTIATLTSYLLTLPIGWIPSQRSREDTPD 419


>UniRef50_C6JBA2 Voltage-gated chloride channel family protein n=1 Tax=Ruminococcus
           sp. 5_1_39BFAA RepID=C6JBA2_9FIRM
          Length = 424

 Score =  235 bits (600), Expect = 2e-60,   Method: Composition-based stats.
 Identities = 88/435 (20%), Positives = 167/435 (38%), Gaps = 52/435 (11%)

Query: 7   RTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLT 66
           +  L L L    IG  +  ++ +++KI +V    LW+  PG   +      +   ++ + 
Sbjct: 13  KNQLELWLFCALIGAVAGALVWILLKIMAVGTEFLWKWFPGKTSVP-----YYTILICVA 67

Query: 67  GIAVGLVIRFSQGHAGPDPACE---PLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPI 123
           G A+  + R   G    D         +        +  ++VA +L L  G S+GPE  +
Sbjct: 68  GAAIIGIFRKIFGDYPEDLETVMEKVRVEKRYEYKNMLVMMVAALLPLLIGSSVGPEAGL 127

Query: 124 MTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSE--- 179
             + + L    G  L   + N   ++ + +A ++  LF  P+    IF    N   +   
Sbjct: 128 TGIIVGLCYWAGDNLKFAKQNTRNYSQIGAAVSMSVLFHAPLFG--IFEVEENSEEDLAA 185

Query: 180 VPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDI-LSGAIVAAIAIAAGM 238
           +    +LF   +A AAG           F   ++ +   +M +I     ++  + I  G+
Sbjct: 186 LTKGSKLFIYGIALAAGTSIYA-GLSALFGAGLSGFPSFDMVEIQRKDYLLMILYILCGL 244

Query: 239 VAVWCLPRLHAMMHQMKN--PVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVAN-QA 295
           +  +     H +   + N  P +V  I   +   +     PV +F G D+M  ++    +
Sbjct: 245 ILAYFYQATHKLTGNISNRFPAVVKEIFAGLCLGITGSFLPVLMFSGEDQMGTLMKTYTS 304

Query: 296 FSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCA 355
           +       +A  KL    +    G +GG  FP +F GV +G  +                
Sbjct: 305 YLPLALIAIAFFKLLLTNLCIQFGLKGGHFFPVIFAGVCMGYGMA--------------- 349

Query: 356 ILGIVLVVTRDGWLSLFMAAVVVPN-----------TTLLPLLCI-VMLPAWLLLAGK-- 401
               +L    DG   +F AA+V  +            T+L  LC  V +  W+ +A    
Sbjct: 350 ----MLTCGPDGGHVVFGAAIVTASLLGGIMKKPLAVTMLLFLCFPVKMFIWIFIAAAVG 405

Query: 402 PMMMVNRPKQQPPHD 416
             ++  +P+Q+P  +
Sbjct: 406 SKLITLKPEQEPSAN 420


>UniRef50_Q0TTC6 Voltage-gated chloride channel family protein n=54 Tax=Firmicutes
           RepID=Q0TTC6_CLOP1
          Length = 418

 Score =  231 bits (588), Expect = 4e-59,   Method: Composition-based stats.
 Identities = 96/405 (23%), Positives = 169/405 (41%), Gaps = 30/405 (7%)

Query: 11  LLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAV 70
           +L L  + +G     +  + + + S   + +W  LPG   +    P W I V ++ GI V
Sbjct: 9   ILILYGIVLGGIVGAVSWLFLYVVSSGIHFMWNELPGKFNL----PYWTILVCSIGGILV 64

Query: 71  GLVIRFSQGHAGPDPACEPLIGA------PVPPSALPGLIVALILGLAGGVSLGPEHPIM 124
           GL     Q + G  P   P + A       V    +P   V+ ++ L  G SLGPE  ++
Sbjct: 65  GLC----QKYLGEYPKLMPEVMAEFKETKRVDYKNVPKACVSALITLFFGASLGPEAALV 120

Query: 125 TVNIALAVAIGARLLPRVNRMEW-------TILASAGTIGALFGTPVAAALIFSQTLNGS 177
            +   L+  +G  L   V   E        T  +   TIG +F  P+       +  + S
Sbjct: 121 NIIGGLSTLVGDFLKWIVKDKELEKYDSLVTEFSMEATIGLIFHAPLIGLTPLIEDDDSS 180

Query: 178 SEVPLWDRLFAPLMAAAAGALT--TGLFFHPHFSLPIAHYGQME--MTDILSGAIVAAIA 233
               +   +++   AA  G L   + +   P F   I H+G     M++I+S   +    
Sbjct: 181 VRKNIKTIVYSITTAAGFGVLILLSQIDNRPSF---IVHFGSFNLGMSEIISIISLIICG 237

Query: 234 IAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVAN 293
           I   ++       LH +   +KN  ++  + G I+  +     P +LF G  E++ +V  
Sbjct: 238 ILMALLYGGYGKILHKIFLPLKNYKIIRALIGGIILGIVGTWLPYTLFSGEHEVKVLVKE 297

Query: 294 -QAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITV 352
             + S     L++++KL    V  ++G+RGG IFP VF GV++G  L       P     
Sbjct: 298 WSSLSIRILILISLVKLFLTEVCLSTGWRGGHIFPVVFSGVSMGYALSAIFSIDPVVTVT 357

Query: 353 SCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLL 397
                     V R+  ++L +  +  P++ +  +L    L A++L
Sbjct: 358 I-VTTAFTSSVLRNAVVTLLLLVLFFPSSLIWIMLIAAFLSAYVL 401


>UniRef50_Q3MBC4 Cl-channel, voltage gated n=7 Tax=Bacteria RepID=Q3MBC4_ANAVT
          Length = 434

 Score =  228 bits (582), Expect = 2e-58,   Method: Composition-based stats.
 Identities = 91/406 (22%), Positives = 168/406 (41%), Gaps = 25/406 (6%)

Query: 17  VAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRF 76
           V +G    L   +   +  ++ +           + +   + ++ V+ + G+ VGLVI F
Sbjct: 39  VMVGTVCGLFAGLYWNVLELMTH----------QLERFESVSLLIVMPIAGLIVGLVIHF 88

Query: 77  SQGHAGPDPACEPLI---GAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVA 133
             G+ G        I   G  +     P +I+A ++ +AGG S GPE P++ V  +    
Sbjct: 89  L-GNPGEIAVIVDNIHFRGGRLDIRKNPAMILASLVSIAGGGSAGPEAPLVQVTGSFGTW 147

Query: 134 IGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMA 192
           +G RL L   +    ++ A A    ALFG P+  A+   + L+    +  ++ L   +++
Sbjct: 148 VGDRLGLQGEDMRSMSLAAMAAGFTALFGAPLGGAMFALEILHHQHIIEYYEALMPAIVS 207

Query: 193 AAAGALTTGLFFH----PHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLH 248
           + A  L   L  H    P +  P   Y    M D     +   I   AG + +       
Sbjct: 208 SCASYLVFALITHLGIAPTWHFP--EYNLENMDDFAWAILFGIIGAVAGWIFMTIFRTCD 265

Query: 249 AMMHQMKNPVLV-LGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVI 307
            +   +  PV +   + G  LG L +   P++ + G  E++  V N  FS     +LA+ 
Sbjct: 266 RLWAMLPVPVYIRTTLAGLGLGTLAIF-LPLTRYFGHQELES-VLNTNFSVVFLLILALG 323

Query: 308 KLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLVVTRDG 367
           K+A++ +    G+RGG I P  F G  +G  +   +P +   + + C +  +   VTR  
Sbjct: 324 KMASISLTVTGGWRGGFIIPLFFTGACVGKAIAILIPGLNPTLAMICTMSALNAGVTRTP 383

Query: 368 WLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNRPKQQP 413
             +  + + +   +   P+L    L  + L    P++      QQ 
Sbjct: 384 ISTTLLLSKLTNFSPFTPIL-FASLIGFFLAPKVPLIASQLKSQQS 428


>UniRef50_C3ATP4 Voltage-gated chloride channel n=9 Tax=Bacillus RepID=C3ATP4_BACMY
          Length = 404

 Score =  221 bits (563), Expect = 3e-56,   Method: Composition-based stats.
 Identities = 87/391 (22%), Positives = 154/391 (39%), Gaps = 20/391 (5%)

Query: 14  LPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLV 73
           +  + +G      + + + + +   + +W+ LP    +      + I V  + G  +GL 
Sbjct: 1   MYGIFLGSIVGATVWLFLVVTNAGIHFVWEYLPKEFALPS---YYTICVTIIGGFLIGL- 56

Query: 74  IRFSQGHAGPDPACEPLIGA------PVPPSALPGLIVALILGLAGGVSLGPEHPIMTVN 127
              SQ + G  P   P + A       +    +    +  I+ L  G SLGPE  ++ + 
Sbjct: 57  ---SQKYFGTYPRLMPEVMAEYKKTGRIEYRFVHQATLTAIIVLVFGASLGPEAALVGII 113

Query: 128 IALAVAIGARLLPRVNRME-WTILASAGTIGALFGTPVAAALIFSQTLNGS-SEVPLWDR 185
             L   +G R    V  M+  T +    T+  +F  P+   L  S+  N   +EV    +
Sbjct: 114 GGLCTWVGDRFHFAVKGMQGLTEIGIGATLSVIFNAPLFGYLAPSENENERLAEVSKGKK 173

Query: 186 LFAPLMAAAAGALTTGLF--FHPHFSLPI-AHYGQMEMTDILSGAIVAAIAIAAGMVAVW 242
               +    AG     L   F    S  +    G   + + ++   +A I  + G     
Sbjct: 174 AIVYVATTLAGFSVYLLLSKFDNRGSFIVNFGEGSFALHEWVAFLPLACIGASIGYFYFK 233

Query: 243 CLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVAN-QAFSTSDY 301
               L  ++H  +   L LGI G I+  +     P ++F G  +++++V      S    
Sbjct: 234 VEHTLEKVVHPFQEYKLTLGIIGGIILGIAGTFLPYTMFSGEHQLKELVNEWTELSFGVL 293

Query: 302 FLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVL 361
           FL  V+KL    V   +G+RGG IFP +F G ++G  +   +P  P A +V+     I  
Sbjct: 294 FLSGVLKLCITAVCLNTGWRGGHIFPIIFAGASIGYAMATVIPLDPIA-SVAIVTTAISS 352

Query: 362 VVTRDGWLSLFMAAVVVPNTTLLPLLCIVML 392
              R       +  +  P   LLP+L   M+
Sbjct: 353 YALRKPIAITVLLLMFFPINLLLPMLGAAMI 383


>UniRef50_B7G9G8 Predicted protein n=1 Tax=Phaeodactylum tricornutum CCAP 1055/1
           RepID=B7G9G8_PHATR
          Length = 1260

 Score =  179 bits (455), Expect = 1e-43,   Method: Composition-based stats.
 Identities = 75/434 (17%), Positives = 147/434 (33%), Gaps = 35/434 (8%)

Query: 13  SLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGI--AV 70
           ++ A+ IG    +   +         + LW  LP    I        +  + L G   AV
Sbjct: 87  AVLALTIGCVCGVAAWLYYMFLEWALDFLWHDLPERFVIDYWPEYLYVLWIPLIGFGMAV 146

Query: 71  GL-VIRFSQGHAGPDPACEPLIGAPVPPSALPGL--IVALILGLAGGVSLGPEHPIMTVN 127
           GL ++    G  G  P     +      +    +  ++A    +  G SLGPE P++ + 
Sbjct: 147 GLGIVVKVMGEPGDLPYTVKCVHEKGYVAMNHVMPMVMASQCSILAGGSLGPEAPLVAIC 206

Query: 128 IALAVAIGARLLPRVNR---MEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWD 184
            AL   +   +    +R    + T++  AG + A FG P+  +L F+  +N    +  ++
Sbjct: 207 AALGGFVSRSVFGMTDRNLVRKHTLMGMAGALAAFFGCPLGGSL-FAMEVNSRFGIEYFE 265

Query: 185 RLFAPLMAAAAGALT----TGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVA 240
                ++      +      GL     + +         + DIL G ++  +        
Sbjct: 266 HTLEAILCGEICLVVFRALAGLPIQAIWDISDDKLEATSVVDILYGCVLGLLGAGVAWGF 325

Query: 241 V----WCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAF 296
                  +              +   + G ++ +L  +  P ++F G  E + +      
Sbjct: 326 ANFHWKVMHMFQHFNLLKNERAIHRAMAGAVVVVLMGMLVPQTMFWGEFEFETIATMAPT 385

Query: 297 ------------------STSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLM 338
                             S     ++ V KL A+    + G+RGG IFPA     ALG  
Sbjct: 386 KDLMHIWPTSGLLGFEMDSFGSAMIVGVAKLIAISFTVSGGYRGGYIFPAFAAAAALGRA 445

Query: 339 LHEHVPAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL 398
           +    P +P  + V C    + + +TR    +  + A +      +  +    L +    
Sbjct: 446 ISILCPFIPVQLCVLCMAAALNVALTRTALATTLILAYLSGEQNSISAILAASLVSLFAT 505

Query: 399 AGKPMMMVNRPKQQ 412
              P +     +  
Sbjct: 506 GYMPFIRSQMVRAD 519


>UniRef50_C2KWR2 Chloride carrier/channel (ClC) family transporter n=1
           Tax=Oribacterium sinus F0268 RepID=C2KWR2_9FIRM
          Length = 442

 Score =  169 bits (428), Expect = 2e-40,   Method: Composition-based stats.
 Identities = 72/301 (23%), Positives = 122/301 (40%), Gaps = 29/301 (9%)

Query: 92  GAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTIL 150
           G  +P    P +I + +L    G S+G E   + V  +L  +IG  L L    +    + 
Sbjct: 112 GEKLPVEMAPLIIFSTVLSHLFGASVGREGAALQVGGSLGSSIGRVLHLSEKEQRRIMMC 171

Query: 151 ASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFS- 209
             +     LFGTP+AAA+   +         +    +  L+     ALT   F       
Sbjct: 172 GMSAAFSGLFGTPIAAAIFAIEL------CTVGSIYYTALLPCTVSALTAHFFAEKVIHA 225

Query: 210 ----LPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQ-MKNPVLVLGIG 264
               L ++   +M+ +  L   ++A  A    +V V C  +   +  +   NP L + + 
Sbjct: 226 EEPDLALSLMAEMDWSSALYTLLLAIAAALVSIVFVSCAHKAKDLFSKYFPNPYLRIFVS 285

Query: 265 GFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLA-VIKLAALVVAAASGFRGG 323
           G I+ +L  +    +++ G   +Q +        +  FL A  +K+    V+   GF+GG
Sbjct: 286 GAIV-LLATLALNTNIYNGTG-IQLITQTIHEPGTKIFLFAFFLKILFTSVSLGGGFQGG 343

Query: 324 RIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTL 383
            I P++F+G  LG  L   +P  P+     CA LG+          +LF      P T L
Sbjct: 344 EIVPSLFIGATLGNALSRFLPLDPSL----CAALGMT---------ALFCGVTNCPLTAL 390

Query: 384 L 384
           L
Sbjct: 391 L 391


>UniRef50_C8XF05 Chloride channel core n=5 Tax=Actinomycetales RepID=C8XF05_NAKMY
          Length = 425

 Score =  150 bits (379), Expect = 7e-35,   Method: Composition-based stats.
 Identities = 98/388 (25%), Positives = 166/388 (42%), Gaps = 22/388 (5%)

Query: 14  LPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLV 73
           + A  +GI  S I    + + S +Q  L+  LP ++        W +  L L G+  GL 
Sbjct: 2   ILAAILGIPISAIAYGFLALVSKIQQYLFTDLPTSVTGGPAPAWWPLPWLLLCGLLTGLT 61

Query: 74  IRFSQGHAGPDPACE-PLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAV 132
           IR+  G+ G  PA      GAP     L G+ +A +  L+ G  LGPE P++ +   LA 
Sbjct: 62  IRYLPGNCGHSPAFGFQTGGAPPTGKELVGVFLAALTTLSLGAVLGPEAPLIAIGGGLAA 121

Query: 133 AIGARLLPRVNRMEWTILASAGTIGA---LFGTPVAAALIFSQTLNGSSEVPLWDRLFAP 189
            +   +      M  TI+ASAG+  A   L G+P+  A +  +   G     L       
Sbjct: 122 LVVRLVRSDAPPMAVTIMASAGSFAAISTLLGSPLLGAFLIMEA-AGIGGATLSLVALPG 180

Query: 190 LMAAAAGALT-------TGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVW 242
           L+A+  GAL        TGL         +       +  +    ++ A+      V   
Sbjct: 181 LLASGIGALIFVGLDNLTGLGTFSLSLGTVPPDSGPTVATLCWAIVMGAVGALLAWVIRS 240

Query: 243 CLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVS-------LFKGLDEMQQMVANQA 295
               L  ++H   N VLV G  G ++G   ++   ++       LF G D M ++V+N A
Sbjct: 241 GALSLRPLVH--TNRVLVTGALGLLVGAAAMVYQLITGHSFTQVLFSGQDAMPELVSNAA 298

Query: 296 FSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCA 355
             +    ++ ++  A     + S FRGG +FP++F+G ALG+     +P +  A  ++  
Sbjct: 299 QYSVGALIVLIVAKAFAYSLSLSAFRGGPVFPSMFIGAALGIA-ASGLPGMTLAPAIAMG 357

Query: 356 ILGIVLVVTRDGWLSLFMAAVVVPNTTL 383
           I  +   + R    S  +A +++ +  L
Sbjct: 358 IGAMCASMLRLPMTSTLLAVLLLGSDGL 385


>UniRef50_C1DC80 Probable voltage-gated chloride channel family protein n=1
           Tax=Laribacter hongkongensis HLHK9 RepID=C1DC80_LARHH
          Length = 460

 Score =  142 bits (358), Expect = 2e-32,   Method: Composition-based stats.
 Identities = 82/403 (20%), Positives = 159/403 (39%), Gaps = 27/403 (6%)

Query: 7   RTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLT 66
           R  L L   A+ +G+A  ++     K+AS+     +   P          +W   +  L+
Sbjct: 36  RQRLALWGGALLVGLAGVVLTWGS-KLASLGTQAAYALSP------WWMLVWTPLMFMLS 88

Query: 67  GIAVGLVIRFSQGHAGPDPACEPLIGAP------VPPSALPGLIVALILGLAGGVSLGPE 120
            + V +    + G                     +        ++A + G++ G + G E
Sbjct: 89  LLIVQVCAPGAAGGGIAQTIATLERRGAFLRERFLTFRVAVVKVLATLTGISAGGTFGYE 148

Query: 121 HPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGAL-FGTPVAAALIFSQTLNGSS 178
            PI+ +  AL  ++G RL +   N +  TILA      A  F TP+A  +   + +  S 
Sbjct: 149 GPIIQIGAALTHSLGRRLGIHSENAIRTTILAGGAASVAAAFNTPLAGIVFAIEEMGRSF 208

Query: 179 EVPLWDRLFAPLMAAAAGALTTGLF-FHPHFSLPIAHY----GQMEMTDILSGAIVAAIA 233
           E      +   ++   AG +T   F  + +F     H+    G      +L+G I  A  
Sbjct: 209 EPRASGIILTAVI--LAGLITMAAFGNYDYFGTTAIHFRALGGSQLAAVLLTGVICGAFG 266

Query: 234 IAAG--MVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMV 291
             A   M+AV    R   +  + + P+L   + G ++ ++G+     S   G +E  ++V
Sbjct: 267 ALAARAMLAVSTGSRSRLLAWRGRQPMLFAAVCGVLIALIGIATHGESFGTGYNEAHRIV 326

Query: 292 ANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAIT 351
              A    ++F   ++KL  ++V+  SG  GG + P++ +G   G  +   +P V     
Sbjct: 327 TGNA-QGLEWF--GIVKLFTMLVSQISGVTGGVLAPSLAIGAGFGYDIGRLLPEVHPQAM 383

Query: 352 VSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPA 394
               ++G     +R     L +   +  + +++  L +  L A
Sbjct: 384 ALLGMVGFFAGFSRSPLTGLVVVMEMTESPSMIVPLMVTALIA 426


>UniRef50_C4KYZ9 Chloride channel core n=1 Tax=Exiguobacterium sp. AT1b
           RepID=C4KYZ9_EXISA
          Length = 394

 Score =  141 bits (355), Expect = 5e-32,   Method: Composition-based stats.
 Identities = 74/389 (19%), Positives = 146/389 (37%), Gaps = 26/389 (6%)

Query: 15  PAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVI 74
            A+ +GI   L+  + + +     +++W  +P    I    P ++  V  + G+++GL+ 
Sbjct: 9   YAIVLGIIIGLVSWLFLSVVYKGIHVVWHTVPEQFDI----PFYLFLVPVIAGVSIGLLQ 64

Query: 75  RFSQGHAGPDPACEPLIG------APVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNI 128
           R      G  P   P +         +    +    +  +L L GG SLGPE  ++ +  
Sbjct: 65  RR----YGQMPRLMPEVMEERKDTGRIDYRLIGFTTLTALLVLIGGASLGPEAALVGIVG 120

Query: 129 ALAVAIGARLLP-RVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLF 187
            L      R+   R    E   +  A  +G +F  P+  A+   +       +     L 
Sbjct: 121 GLTTWFSERIRYVRQELGELQEVGHAVVLGIVFNAPLFGAIAAEENEQKKQPM---LNLL 177

Query: 188 APLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAI-AIAAGMVAVWCLPR 246
           A L       L   L   P F   I  + +ME   +    I+  +  I  G + +     
Sbjct: 178 ATLAGIGTFYLLNQLDERPPF---IIKFPEMETIQLNWTVILIVLSGILLGWLYLISEHA 234

Query: 247 LHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVAN-QAFSTSDYFLLA 305
           +  +   +   +L+  +GG  +G + ++  P  LF G + + + +   +        L +
Sbjct: 235 MMQLFSNVPI-LLLTTLGGVGIGGMALLY-PDLLFSGEETILEYIDEWRLIPLYTLLLFS 292

Query: 306 VIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLVVTR 365
           V+KL       A+G+RGG I+P +F    LG              +V      ++    R
Sbjct: 293 VLKLLFTAFCLATGWRGGHIYPLLFSSFTLGYFFSLLFDID-MTFSVVLTTSALLATAMR 351

Query: 366 DGWLSLFMAAVVVPNTTLLPLLCIVMLPA 394
                + +  +  P  + L +  +V + +
Sbjct: 352 QPLAIIVLLVLFFPPNSWLYVFAVVAIVS 380


>UniRef50_A0LDC4 Cl-channel, voltage-gated family protein n=1 Tax=Magnetococcus sp.
           MC-1 RepID=A0LDC4_MAGSM
          Length = 582

 Score =  137 bits (345), Expect = 7e-31,   Method: Composition-based stats.
 Identities = 71/396 (17%), Positives = 147/396 (37%), Gaps = 18/396 (4%)

Query: 20  GIASSLILIVVMKIASVLQNLLWQRLPGTLG--IAQDSPLWIIGVLTLTGIAVGLVIRF- 76
           G+      I+   +    Q+L +      +   I+      +I    L G  VG ++ F 
Sbjct: 24  GVMVGYGAILFRTLIEGFQHLFFGSSAEDMVQVISGLQWWHVILAPMLGGAIVGPLVHFV 83

Query: 77  ---SQGHA-GPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAV 132
              S+GH      A   L GA +      G + A  + +  G S+G E P++ +   LA 
Sbjct: 84  FPGSRGHGVPEVMAAVALHGAKMNLKDGIGKMFACSISIGSGGSVGREGPVVHLGATLAS 143

Query: 133 AIGARLLPRVNRMEWTILASAGTIGAL-FGTPVAAALIFSQTLNGSSEVPLWDRLFAPLM 191
             G +L      M   +   A    A  F  P+A  +   + +     +  +      ++
Sbjct: 144 WFGKQLNMSTKHMRTMVGCGAAAGIAASFNAPIAGVMFALEVILADYALATFS---PIVL 200

Query: 192 AAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMM 251
           ++    +   L      +  + HY  +   +I +   +  +    G++ +  L +   ++
Sbjct: 201 SSVIATVIARLHLGDFPAFIVPHYTLVSAWEIPAYVGLGLVCGLTGILFMHTLFKAEDVI 260

Query: 252 HQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAA 311
            ++  P  +  + G +L  L  +  P  +  G D M + +  Q        +L  +K+ A
Sbjct: 261 GKIAVPRWIKPMFGGMLLGLIALQFPQIMGVGYDTMNKALLEQMI-GPTMLMLVFVKILA 319

Query: 312 LVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAIT------VSCAILGIVLVVTR 365
             +   SGF GG   P++F+G  +G     +  A+  AI+          +  +   V  
Sbjct: 320 TSLTLGSGFSGGVFTPSLFLGAMVGGAFGTYAHALFPAISAGPGAYTLVGMGAMAAAVLG 379

Query: 366 DGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGK 401
               S+ +   +  +  ++  L +  + A LL+   
Sbjct: 380 APIASILILFELTGDYRIMLALMVASIVATLLINQV 415


>UniRef50_B8C337 Chloride channel protein (Fragment) n=1 Tax=Thalassiosira
           pseudonana RepID=B8C337_THAPS
          Length = 312

 Score =  137 bits (344), Expect = 9e-31,   Method: Composition-based stats.
 Identities = 64/308 (20%), Positives = 111/308 (36%), Gaps = 34/308 (11%)

Query: 105 VALILGLAGGVSLGPEHPIMTVNIALAVAIGARLL---PRVNRMEWTILASAGTIGALFG 161
           +A  + L  G SLGPE P +   ++L   +                    +A  + A F 
Sbjct: 8   LAATVTLGTGNSLGPEGPSVEAGMSLNYEMTEVQRVNRKMARDRLLLACGAAAGVSAGFN 67

Query: 162 TPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQME-- 219
            P++      + +  + ++ +     A L+A+   ALT  L      SL +  +      
Sbjct: 68  APLSGVFFALEIVQNAFQINIS----AILLASVVSALTIQLLLGSELSLRLGSFDFKNPL 123

Query: 220 ---------------MTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIG 264
                          +  I SG    +  +  G      +      + +   P+    I 
Sbjct: 124 LELPLYLLLGAMSGVVAAIFSGVAQYSKTVFDGEEGPEIVQETFRQIPKYAKPL----IA 179

Query: 265 GFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGR 324
             I G++G+   P  LF G + +  +  N   ST   FLL + KL    ++A+SG  GG 
Sbjct: 180 SLICGVVGIYV-PQVLFFGYETLNGLFLNNDISTPYLFLLLIAKLMTTAISASSGLVGGT 238

Query: 325 IFPAVFVGVALGLMLHEHVPAVP-----AAITVSCAILGIVLVVTRDGWLSLFMAAVVVP 379
             P++F+G  LG + H   P V       A  +  A   +  +       SL +      
Sbjct: 239 FAPSLFLGGVLGAVFHNIYPIVHGISGLPAFAMVGAASVLAALFRAPLTASLLLFECTRN 298

Query: 380 NTTLLPLL 387
              +LPL+
Sbjct: 299 YDVILPLM 306


>UniRef50_C8WIS7 Chloride channel core n=2 Tax=Coriobacteriaceae RepID=C8WIS7_EGGLE
          Length = 417

 Score =  137 bits (344), Expect = 9e-31,   Method: Composition-based stats.
 Identities = 74/418 (17%), Positives = 149/418 (35%), Gaps = 25/418 (5%)

Query: 8   TMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTG 67
              L     +  G  +   + +++   ++    +W RLP   G     P + +    + G
Sbjct: 8   NRTLFVASVIVTGAIAGAFVWLLLFAMNLGITFIWDRLPAHFG-----PYFPLAACLVGG 62

Query: 68  IAVGLVIRFSQGHAGPDPACEPLI--GAPVPPSALPGLIVALILGLAGGVSLGPEHPIMT 125
           + +GL  +    +          +          L  + V+ +L L  G S+GPE  +  
Sbjct: 63  LVIGLFAKKFGSYPEDLNQVMAKVKRDGRYDYDKLGVMSVSALLPLFFGGSVGPEAGLTG 122

Query: 126 VNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSE----- 179
               +   +G R+     +  + T + +   + A+F  P+             ++     
Sbjct: 123 AVAGICTWVGDRMKRFGSDFQQLTSVGTMAALSAIFTAPLFGFAAPLYDDGDEAKGAQAA 182

Query: 180 --VPLWDRLFAPLMA---AAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAI 234
             +P   ++   L A   A A  L  G  F    SLP      +  T++L    +A +  
Sbjct: 183 ITLPKSSKIVVYLCAIAGALAAFLGLGALFGGGLSLPRFTDIHVGATELLWLVPLALVGA 242

Query: 235 AAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVAN- 293
           A G +          +  +M    +   +   ++  L  I  P ++F G  + +Q+    
Sbjct: 243 AGGWLFCAFDGLFERLSERMGERPVAKALIAGLVLALMGIALPFTMFAGETQAEQLGEVW 302

Query: 294 QAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVS 353
              +          K+    +    G+RGG  FP +F G+++G  +     A P    + 
Sbjct: 303 GTMTAFALLATGFGKVLVTPLCIRFGWRGGHFFPVIFAGISIGYGMAMLTGADPV-FCLC 361

Query: 354 CAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNRPKQ 411
            +   +V  V R   +++ +  +  P   +     +VML A  L A  P+    R +Q
Sbjct: 362 ASTAALVGGVMRQPLMTVLLLFLCFPVKGI-----VVMLAAAALGAAVPLPKALRAEQ 414


>UniRef50_C4ZAT1 Chloride channel protein EriC n=9 Tax=Bacteria RepID=C4ZAT1_EUBR3
          Length = 423

 Score =  136 bits (343), Expect = 1e-30,   Method: Composition-based stats.
 Identities = 72/415 (17%), Positives = 140/415 (33%), Gaps = 49/415 (11%)

Query: 5   RARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLT 64
           R  T +   + ++ +GI +           SV+ +             +    W+I  L 
Sbjct: 19  RLITSIKWVIFSIVVGIVAGSCGTAFYFALSVVTDF------------RMKYPWLIYFLP 66

Query: 65  LTGIAVGLVIRFSQGH---AGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEH 121
           + G+A+  +    +                G  VP    P + V+ ++    G S G E 
Sbjct: 67  IGGLAIVGLYHLCKDDNDTGTNLVISAIHSGDKVPFIMAPLIFVSTLITHLFGGSAGREG 126

Query: 122 PIMTVNIALAVAIGARLLPRVNRMEWTI-LASAGTIGALFGTPVAAALIFSQTLNGSSEV 180
             + +  ++  +IG             I    +    ALFGTP+AAA+   +       +
Sbjct: 127 AALQMGGSIGSSIGRVFRFDEKDKHVMIMCGMSAAFSALFGTPMAAAIFSMEM------I 180

Query: 181 PLWDRLFAPLMAAAAGALTTG----LFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAA 236
            +    +  L+     +L        F   +    I +     + + +  +++A +    
Sbjct: 181 SVGVMYYIALVPCVISSLIAHGIASYFNVTNEFFAIENIPDFTILNSVKISVLAILCALV 240

Query: 237 GMVAVWCLPRLHAMMHQM-KNPVLVLGIGGFILGILGVIGGPVSL-FKGLDEMQQMVANQ 294
            ++    L    A+  +   N    + IGG  + I  ++ G  +    G+  +Q  +   
Sbjct: 241 SILFCVALHSGEALYKKYLPNKYTRVFIGGCFIIIATMLVGNQTYNGTGMSVIQSSIDGS 300

Query: 295 AFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSC 354
               +        K+    +   +GF+GG I P+ F+G   G +        P+      
Sbjct: 301 VRPEAFLL-----KIIFTALTLGAGFKGGEIVPSFFIGATFGCLFGNLTGFEPSL----- 350

Query: 355 AILGIVLVVTRDGWLSLFMAAVVVPNTTLLP---LLCIVMLPAWLLLAGKPMMMV 406
                    T  G +SLF      P T+LL    L     +P +LL      M+ 
Sbjct: 351 --------CTAVGMISLFCGVTNCPITSLLISFELFGYDGMPYFLLAIPFSYMLS 397


>UniRef50_Q64C69 Chloride channel n=1 Tax=uncultured archaeon GZfos26B2
           RepID=Q64C69_9ARCH
          Length = 608

 Score =  134 bits (336), Expect = 9e-30,   Method: Composition-based stats.
 Identities = 72/440 (16%), Positives = 149/440 (33%), Gaps = 45/440 (10%)

Query: 3   HPRART--MLLLSLP-AVAIGIASSLILIVVMKIASVLQNLLWQR--------------- 44
           H R      +   +P ++ IG+A+    ++   + SV+ + +                  
Sbjct: 15  HLRKLNFEYIEHWVPYSILIGLAAGASAVIFYSLLSVVSHYVLGGIGHCYSTPTGCEQPL 74

Query: 45  --LPGTL---GIAQDSPLWIIGVLTLTGIAVGLV-IRFSQGHAGP--DPACEPLIG--AP 94
             +P  +    +A     +++ +  + G+  GL+  R++    G   D   +        
Sbjct: 75  LLVPSVIPPGSLADLHTWYLVAIPVIGGLVAGLITYRYAPEAVGEGTDAVIDSYHQQQGR 134

Query: 95  VPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARLLPRVN-RMEWTILASA 153
           +         +A  + +  G S G E PI  +       +  +L    N R    +  +A
Sbjct: 135 IRGRIPIVKTIASAITIGTGGSAGREGPITQIGAGFGSYLADKLKLDDNGRRMMLLCGAA 194

Query: 154 GTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIA 213
           G IG++F  P+  AL     L        ++ L    +++          F         
Sbjct: 195 GGIGSIFRAPLGGALFAISVLYKRDSE--FESLVPAFISSIIAYSVFCSVFGWGSLFTTP 252

Query: 214 HYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMM--HQMKNPVLVLGIGGFILGIL 271
            Y      +++  AI+  +    G++ +     +  +    ++KN    +  G  +  ++
Sbjct: 253 DYTFTHPAELVFDAILGILCGLVGILHIKTFHGIRDLFKKWKIKNYFKPMIGGLLLGLLV 312

Query: 272 GVIGG----PVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFP 327
             +         +F G  E  Q   +   +     L  + K+ A      SG  GG   P
Sbjct: 313 LSVHQSCGCGYCIFGGGYESVQSAIDGELAVEVLILFVLAKILATSFTLGSGGSGGVFAP 372

Query: 328 AVFVGVALGLML----HEHVPAV----PAAITVSCAILGIVLVVTRDGWLSLFMAAVVVP 379
            + VG  LG       H   P +     +   V   +  ++  V R    ++ + + +  
Sbjct: 373 TLAVGATLGGAFGIVAHALFPGIIGDMQSTSFVLIGMAALLAGVARVPIAAIVIVSELTG 432

Query: 380 NTTLLPLLCIVMLPAWLLLA 399
           N  LLP L      A+L+  
Sbjct: 433 NYNLLPPLMFASTIAYLVTT 452


>UniRef50_A3YZH8 Chloride channel-like protein n=1 Tax=Synechococcus sp. WH 5701
           RepID=A3YZH8_9SYNE
          Length = 659

 Score =  131 bits (329), Expect = 5e-29,   Method: Composition-based stats.
 Identities = 86/300 (28%), Positives = 136/300 (45%), Gaps = 14/300 (4%)

Query: 48  TLGIAQDSPLWIIGVLTL-TGIAVGLVIRFSQGHAGPDPACEPLIGAPVPP-SALPGL-I 104
            +G A     W + +  L  G+AVGL+ +  +      P+   +     P    LPGL +
Sbjct: 123 AIGPAGWLASWPVVIAPLLGGVAVGLLRQLGRDLGPSLPSLMAMADGAAPALPRLPGLRL 182

Query: 105 VALILGLAGGVSLGPEHPIMTVNIALAVAIGAR-LLPRVNRMEWTILASAGTIGALFGTP 163
           VA  L L  G SLGPE P +     L + +G R  LP  ++        A  + A F  P
Sbjct: 183 VAASLSLGSGASLGPEGPSVESGGNLGLWVGLRGRLPPESQKALVAAGVAAGLAAGFKAP 242

Query: 164 VAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFF--HPHFSLPIAH-YGQMEM 220
           +A   +F       S +P    L A L+AA A +L T L     P F LP       +E+
Sbjct: 243 IAG--VFFAFEGAYSAIPGRPSLRAVLVAAVASSLVTQLCLGDEPIFRLPAYEVRSPLEL 300

Query: 221 TDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKN--PVLVLGIGGFILGILGVIGGPV 278
              L   +VA++ ++  +V++    R   + H        L+ G+GG  +G+L  +G P 
Sbjct: 301 PLYLGLGLVASL-MSWALVSLLAAGRSEPVQHWFSRLPLWLINGLGGLAVGVLA-LGFPQ 358

Query: 279 SLFKGLDEMQQMV-ANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGL 337
            L  G D ++ ++ +    + +    L V+KL A  ++ A+GF GG   PA+F+G  LG 
Sbjct: 359 VLGVGYDTIEALLGSEGGVALTTLAALLVVKLLATGLSNATGFVGGGFAPALFLGAVLGN 418


>UniRef50_C7R845 Chloride channel core n=1 Tax=Kangiella koreensis DSM 16069
           RepID=C7R845_KANKD
          Length = 591

 Score =  131 bits (329), Expect = 5e-29,   Method: Composition-based stats.
 Identities = 75/362 (20%), Positives = 138/362 (38%), Gaps = 20/362 (5%)

Query: 17  VAIGIASSLILIV---VMKIASVLQNLLWQRLPGT-LGIAQDSPLWIIGVLTLTGIAVGL 72
             IG+   L+      + ++ +    +LW   P +         L+ + + T+ G+ VGL
Sbjct: 21  ALIGLICGLLAGGSNILFRLFTESSLVLWATDPNSNTDYETMDWLYRLLLPTIGGLIVGL 80

Query: 73  VIRFS-----QGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVN 127
           +++       Q                +PP       +   L +A G S+G E P + + 
Sbjct: 81  LLQQLKPEHRQVGVSHVLERMSYHQGHLPPQNAFVQFILGGLTIASGQSVGREGPGIHLG 140

Query: 128 IALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRL 186
            A A  +G +L LP  +         A  I A F TP+A  +   + +     V      
Sbjct: 141 SASASWVGQKLKLPNNSTRILVGCGCAAAISANFNTPLAGVIFAMEIIIMEYAVA---SF 197

Query: 187 FAPLMAAAAGALTTGLFFHPHFSLPIAH-YGQMEMTDILSGAIVAAIAIAAGMVAVWCLP 245
              ++A+ AGA+ T L F    S  +        + ++    +V         V +    
Sbjct: 198 IPIILASVAGAILTRLVFGDGASFDVPSKLDIQSLWEMPYFLLVGFAGGVFASVFIMATR 257

Query: 246 RLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLA 305
           ++  +  +     L   + G  +GI+  IG P  +  G D +   +  +   T    L  
Sbjct: 258 KVRQISREWPV-WLKTTVAGTSVGIIA-IGIPQVMGIGYDSVNGALQGELALTILA-LAL 314

Query: 306 VIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEH---VPAVPAAITVSCAILGIVLV 362
           V KL A ++ +     GG I PA+F+G  LG ++      +    A+ T   A++G+  V
Sbjct: 315 VGKLIATIICSGLSLPGGVIGPALFMGAMLGGVMGNIGGELFPDQASYTGFYAMIGMATV 374

Query: 363 VT 364
           + 
Sbjct: 375 MG 376


>UniRef50_O54193 Putative membrane protein n=3 Tax=Streptomyces RepID=O54193_STRCO
          Length = 452

 Score =  131 bits (329), Expect = 5e-29,   Method: Composition-based stats.
 Identities = 89/394 (22%), Positives = 149/394 (37%), Gaps = 18/394 (4%)

Query: 20  GIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRFSQG 79
           G+  +L     + +   LQ+ +W  LP   G       W +  L L G+ +  ++    G
Sbjct: 36  GVPIALACFFFVGLQHELQHWVWTSLPEAAGYDTPPWWWPLPALVLAGLILAPIVTRMPG 95

Query: 80  HAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARLL 139
             G  P    L GAPV P ALPG ++A +  L  GV LGPE P+M V   LA+    R  
Sbjct: 96  GGGHLP-VNGLGGAPVGPRALPGAVLAALATLPLGVVLGPEAPLMAVGSGLALLAVRRAG 154

Query: 140 PRVNRMEWTILASA---GTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAG 196
              ++    ILA+A     I  + G P+AAA++  +    +    +   L   L +A   
Sbjct: 155 AGGDQQASAILATAGSTAAISTILGGPIAAAVLLIEGAGLAGTQLVALLLPCLLASATGA 214

Query: 197 ALTTGLFFHPHFSLPIAHYGQM------EMTDILSGAIVAAIAIAAGMVAVWCLPRL--- 247
            + TG        +       +      +  D L G   AA+      +A     R    
Sbjct: 215 LVFTGFGQWTGLEIGALSLPDLPPQANPDAGDFLWGLPTAALIAVLVTLARALGRRTVSW 274

Query: 248 --HAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLA 305
             H    +       +G+      ++       +   G   + Q+ A+    +    +  
Sbjct: 275 TRHRTAARTVACATAVGVCVAAYALITGRSPAEAALSGQATLAQLAAHPHAWSVGALVAL 334

Query: 306 VIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLVVTR 365
           V         A    RGG IFPAV +G A  L     +P   A   ++  I      VT 
Sbjct: 335 VACKGLAWGIALGALRGGPIFPAVLLGAATALACSG-LPGFGATPALALGIAAAAAAVTG 393

Query: 366 DGWLSLFMAAVVVPNTT--LLPLLCIVMLPAWLL 397
               S  +A +++   +   +PL+ +  + A+++
Sbjct: 394 LPLASSVLAVLLMGRDSHDQMPLIVMASVVAFVV 427


>UniRef50_B0G1X5 Putative uncharacterized protein n=1 Tax=Dorea formicigenerans ATCC
           27755 RepID=B0G1X5_9FIRM
          Length = 428

 Score =  130 bits (327), Expect = 8e-29,   Method: Composition-based stats.
 Identities = 72/365 (19%), Positives = 141/365 (38%), Gaps = 24/365 (6%)

Query: 56  PLWIIGVLTLTGIAVGLVIRFS--QGHAGPDPACEPLIGAP--VPPSALPGLIVALILGL 111
            +W++ +L   G+ +  +   +  + +AG D     +      +P    P +++A  L  
Sbjct: 59  HMWMVYLLPFAGLMIVFLYHVTGQEKNAGTDMVLMVVRSDQNTMPGRVAPLILIATALTH 118

Query: 112 AGGVSLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIF 170
             G S G E   +    +L   +G ++ L   ++   T+   +    ALFGTP+AAA+  
Sbjct: 119 LFGGSAGREGAALQFGASLGNWLGRKIHLNESDKRIMTLAGMSAAFAALFGTPMAAAVFP 178

Query: 171 SQTLNGSSEVPLWDRLFAPLMAAAAGALT---TGLFFHP---HFSLPIAHYGQMEMTDIL 224
            +       + +    +A L+     A       +F          P+            
Sbjct: 179 MEV------ISVGIMYYAALVPCVFSAFIGERISIFMGVRTLTAPYPVEEVPNFYGIAWG 232

Query: 225 SGAIVAAIAIAAGMVAVWCLPRLHA-MMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKG 283
              ++A     AG +    L      +    +NP L + +GG  + +L  I G  +    
Sbjct: 233 KAILLAICFAFAGALFCVMLHIFEKQLKKWFQNPYLRVFVGGVTVVLLWKITGTDT---- 288

Query: 284 LDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHV 343
              +      Q+F+      + ++K+    +   SGF+GG I P++F+G   G  L    
Sbjct: 289 YLGLGGGTIAQSFAEPQKLWVFLLKILFTCITLCSGFKGGEIVPSLFIGATFGSALAPIF 348

Query: 344 PAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPM 403
             +P  I  +C ++G+   VT     SL +A  +      +P  C V+  ++LL   + +
Sbjct: 349 -GLPVDICAACGMVGVFCAVTNSPISSLLIAFELF-GFAGMPYFCTVIAVSYLLSGYQSL 406

Query: 404 MMVNR 408
               +
Sbjct: 407 YKAQK 411


>UniRef50_D1JC90 Probable voltage gated chloride channel n=2 Tax=uncultured archaeon
           RepID=D1JC90_9ARCH
          Length = 612

 Score =  126 bits (316), Expect = 1e-27,   Method: Composition-based stats.
 Identities = 80/457 (17%), Positives = 161/457 (35%), Gaps = 50/457 (10%)

Query: 5   RARTMLLLS-LPAVAIGIASSLILIVVMKIASVLQNLLWQRLPG-------------TLG 50
           + R  +    L ++ IGI +         +  ++ +     L G              + 
Sbjct: 10  KERKYIQRWVLLSILIGIVAGFGAFAFYLLLQIMTDFFLGYLAGFQPTPPAGEQDVPYIS 69

Query: 51  IAQDS-PLWIIGVLT-LTGIAVGLVI-RFSQGHAGP--DPACEPLIGAPVPPSALPGLI- 104
           +      LW++ ++  L G+ VGL+I  F+    G   D   +              LI 
Sbjct: 70  LPTAPFHLWVLALMPALGGLIVGLIIYSFAPEAEGHGTDAIIDAFHNKKGVIRKRVPLIK 129

Query: 105 -VALILGLAGGVSLGPEHPIMTVNIALAVAIGARLLPRV-NRMEWTILASAGTIGALFGT 162
            +A  + +  G S G E PI  +       +G +L           +  +A  IGA+F  
Sbjct: 130 AIASAITIGSGGSAGREGPIAQIGGGFGSFLGTKLKLGERETRMMMVCGAAAGIGAMFKA 189

Query: 163 PVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTT----GLFFHPHFSLPIAHYGQM 218
           P+ +AL  ++ L         + L   ++++            + +HP F  P   +   
Sbjct: 190 PLGSALFGTEVLYKRDFE--MESLIPAIVSSVVAYAVFCSIPSIGWHPIFDTPPYTFTH- 246

Query: 219 EMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNP-VLVLGIGGFILGILGVIGGP 277
              +++  A++     A G+  +       A   ++  P  L   IGG ++GI  ++ G 
Sbjct: 247 -PKELIFFAVLGIACTALGIFYIKVFYATRAFFKRLAIPNHLKPAIGGALVGIFVLVIGY 305

Query: 278 V-------SLFKGLDEMQQMVANQ---AFSTSDYFLLAVIKLAALVVAAASGFRGGRIFP 327
           V        L  G   +Q  +  +           ++A+ K+        SG  GG   P
Sbjct: 306 VEPQALDGILGMGYGTVQTAIDMELPLPELIELMIIVAIAKIFTTSFTIGSGGSGGVFAP 365

Query: 328 AVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLV--------VTRDGWLSLFMAAVVVP 379
           ++ +G  LG +           I     +   V+V          +    ++ M + +  
Sbjct: 366 SLVIGAMLGGLFGGVSHFFFPEIITETTMSAFVVVGMAAFFAGAAKVPIAAILMISEMAG 425

Query: 380 NTTLLPLLCIVMLPAWLLLAGKPMMMVN-RPKQQPPH 415
           + +LL  L +  + A+ L  G  +     + +++ P 
Sbjct: 426 SYSLLVPLMLTSVVAYALSGGWTIYEKQVKTRKESPA 462


>UniRef50_B8DDG6 Membrane protein, putative n=19 Tax=Listeria monocytogenes
           RepID=B8DDG6_LISMH
          Length = 420

 Score =  126 bits (316), Expect = 2e-27,   Method: Composition-based stats.
 Identities = 73/403 (18%), Positives = 152/403 (37%), Gaps = 23/403 (5%)

Query: 7   RTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLT 66
           +  L+ S+    +GI   +I  + + +       LW  LP        S  + + V  + 
Sbjct: 15  KVTLVFSVYTFILGILVGVIAALFLAMVHFATTFLWDYLPNQFDF---SWYYPLLVGLIG 71

Query: 67  GIAVGLVIRFSQGHAG---PDPACEPLIGAPVPPSALPG-LIVALILGLAGGVSLGPEHP 122
              VG+V +   G       D   E      +    +    I++  + L  G S+GPE  
Sbjct: 72  SFFVGMV-QLKFGDYPRSMHDNVAEAKKTGRMEYRKVLLPTILSAWIILTFGASVGPEAA 130

Query: 123 IMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVP 181
           ++ +       I   L L   ++ E   L+    I ++F  P +         + + ++P
Sbjct: 131 LIGIVGGATTWIIDHLKLSMAHKEELVSLSVGAIISSIFHAPFSGLAEEIDESSQAKKIP 190

Query: 182 LWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYG--QMEMTDILSGAIVAAIAIAAGMV 239
              +L   L+ +   AL + L+      +P + +     +M       ++    I  G +
Sbjct: 191 KNSKLVLSLLIS-FSALGSFLWLKSFLKMPASIFAIRLPDMGWSWWFILLFIPMIILGWL 249

Query: 240 AVWCLPRLH----AMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVAN-Q 294
                 +L          +KN ++   IGG  +G+ G+I     LF G  ++ ++    Q
Sbjct: 250 FSVYFQQLQVYIAKAASVIKNKMVAAVIGGLSIGLFGIISS-FMLFSGEHQLIELTTTVQ 308

Query: 295 AFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSC 354
            +S     ++A++K   + +  A+G+ GG IFPA+F    +G  +            ++ 
Sbjct: 309 NYSIPFLLIIALLKPVLVAICLATGWNGGAIFPAIFTSTIMGY-IATFWMDGSTGFLITV 367

Query: 355 AILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLL 397
            +      +     L+  +   + P    L     ++L A+++
Sbjct: 368 FVTACCTKIVGKPVLTASILLFIFP----LQFFPFILLTAFIV 406


>UniRef50_A6DFZ2 Chloride channel family protein n=1 Tax=Lentisphaera araneosa
           HTCC2155 RepID=A6DFZ2_9BACT
          Length = 613

 Score =  126 bits (315), Expect = 2e-27,   Method: Composition-based stats.
 Identities = 73/356 (20%), Positives = 121/356 (33%), Gaps = 17/356 (4%)

Query: 66  TGIAVGLVIRFSQG--HAGPDPACEPLIGAPVPPSALPGLI--VALILGLAGGVSLGPEH 121
            G+A  LV RF+    + G     +                  +A I+ LA G S G E 
Sbjct: 99  CGLAAYLVRRFAPNAAYDGTSALVDTFHNKRAKMKLSTAFTKGIASIITLASGGSGGKEG 158

Query: 122 PIMTVNIALAVAIGARLLPRVNRMEWTIL-ASAGTIGALFGTPVAAALIFSQTLNGSSEV 180
           P+  V       +  +L   V       L   AG +GA+F  P+ AA+   + L      
Sbjct: 159 PVAQVGAGCGSYLADKLKLSVKERRVLFLSGCAGGLGAIFRAPLGAAITAVEVLYKEDFE 218

Query: 181 PLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQME-MTDILSGAIVAAIAIAAGMV 239
              + +   ++A+     T  L F  H    +      E    I S  ++A    A G  
Sbjct: 219 --SEAIMPCVIASVTSYSTFMLTFGSHTIFNLGEVESFEGFFHIPSYILLALTCSAIGAF 276

Query: 240 AVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTS 299
            V           ++K P  +  + G +L  L  +  P +L  G   +Q+++     +  
Sbjct: 277 YVKFYQFTKEFFIKLKIPTPIKPVVGGMLTGLLALIMPYALGDGWGAIQEVMDGN-LTLG 335

Query: 300 DYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGV----ALGLMLHEHVPAVP----AAIT 351
              L  ++K+ A  +   SG   G   P++F+G      LG  LH   P  P        
Sbjct: 336 FIALAVIVKIVATSLTIGSGGSAGIFGPSLFIGAMTGGCLGSFLHMQFPDNPMVPSITAF 395

Query: 352 VSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVN 407
           V   +      V      S+ M   +     LL  L +    + L  +   +    
Sbjct: 396 VMVGMAAFFAGVANAPIASIIMVCEITGTYNLLAPLLLTSAFSMLFNSKVSIFKPQ 451


>UniRef50_B7G8L3 Predicted protein n=1 Tax=Phaeodactylum tricornutum CCAP 1055/1
           RepID=B7G8L3_PHATR
          Length = 649

 Score =  125 bits (314), Expect = 3e-27,   Method: Composition-based stats.
 Identities = 72/342 (21%), Positives = 121/342 (35%), Gaps = 56/342 (16%)

Query: 106 ALILGLAGGVSLGPEHPIMTVNIALAVAIGARLLPRVNRME------WTILASAGTIGAL 159
           A +  L  G SLGPE P + + + +A          ++R             +A  + A 
Sbjct: 230 AAVFTLGTGCSLGPEGPCVEIGMNVARGCMDVKPEFLSRPRPHWNVCLLNCGAAAGVAAG 289

Query: 160 FGTPVAAALIFSQTLNG-------------------------SSEVPLWDRLFAPLMAAA 194
           F  P+A      + +                           S+ V   + +   L+A+ 
Sbjct: 290 FNAPLAGVFFTLEVMQSALNGVRQEEQEKQTLQGNNSDLNAASNAVSATENITPILLASV 349

Query: 195 AGALTTGLFFHPHFSLPIAHYGQMEMTDILS-----GAIVAAIAIAAGMVAVWC------ 243
             AL           L ++ Y        L      G I   +A +    A W       
Sbjct: 350 LSALVARTILGDTLVLSLSEYSLETPLIELPLYLLLGVISGFVAFSFSKAANWSQAFFSG 409

Query: 244 ---LPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSD 300
                 + + M  +  PV  + IGGF  G++G++  P  LF G + +  ++AN +  TS 
Sbjct: 410 EVGGESIQSFMSCLPEPVKPV-IGGFACGLVGLV-FPQILFFGYETLNSLLANASLPTSL 467

Query: 301 YFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAI---------T 351
            F L ++K     V+A SG  GG   P++F+G  +G   H     V   +          
Sbjct: 468 LFSLLIVKTIMTAVSAGSGLVGGTFAPSLFLGAMVGAAFHNVATIVFQTLMTSFPWESVG 527

Query: 352 VSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLP 393
           V  +    VLV+      ++  AA V+      PL   ++L 
Sbjct: 528 VLSSTAAPVLVLADVPAYAMVGAASVLAALFRAPLTASLLLF 569


>UniRef50_Q3A443 Chloride channel protein EriC n=2 Tax=Desulfuromonadales
           RepID=Q3A443_PELCD
          Length = 606

 Score =  124 bits (312), Expect = 5e-27,   Method: Composition-based stats.
 Identities = 74/411 (18%), Positives = 136/411 (33%), Gaps = 29/411 (7%)

Query: 14  LPAVAIGIASSLILIVVMKIASVLQNLL---WQRL--PGT----------LGIAQDSPLW 58
           L +  +G+ +    +            +   W  L  PG             +      +
Sbjct: 27  LLSALVGLVAGAGALAFYFATDTATEWILVHWGGLHTPGHGNALQSGGVVNSLKMSHRWF 86

Query: 59  IIGVLTLTGIAVG-LVIRFSQGHAGP--DPACEPLIGAPVPPSALPGLI--VALILGLAG 113
           +  +  L G+  G LV RF+    G   D A E              ++  +A +  ++ 
Sbjct: 87  LFVIPVLGGLVSGWLVFRFAPEAEGHGTDAAIEAFHQKKGLIRGRVPVVKAIASVATIST 146

Query: 114 GVSLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQ 172
           G S G E PI  +       +  RL L   +R    +   AG +GA F  P+  AL   +
Sbjct: 147 GGSAGREGPIAQIGAGFGSFLADRLKLSVSDRRVLLLAGMAGGVGATFRAPLGGALFAVE 206

Query: 173 TLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAI 232
            L    E    + L   ++++       G        L    +      ++    ++   
Sbjct: 207 VLYQDPEFEH-EGLIPCIISSIVAYSLFGAVTGWSPLLATPAFRFEHPVELGFYLLLGIA 265

Query: 233 AIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVA 292
               G   V            +  P  +    G ++  +  +  P  L  G   +Q  + 
Sbjct: 266 CAILGTGYVKTFYYARDRFVALNMPTWLKPALGGLILGVMAMFVPQVLGSGYGWVQAALY 325

Query: 293 NQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVAL----GLMLHEHVPAV-- 346
            +  +     LL + K+ A  +  +SG  GG   P++ +G  L    G ++H   P +  
Sbjct: 326 GK-MALWLMVLLGLGKIIATSLTISSGGSGGVFAPSLVIGAMLGGSFGAVVHALFPMLLA 384

Query: 347 PAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLL 397
                V   + G    V      +L M + +  N  LL  L +V + A + 
Sbjct: 385 EPRTCVIIGMAGFFAGVANTPIATLIMVSELTGNYALLAPLMLVCVVAMVF 435


>UniRef50_C9R8B5 Cl-channel voltage-gated family protein n=2 Tax=cellular organisms
           RepID=C9R8B5_AMMDK
          Length = 598

 Score =  121 bits (304), Expect = 4e-26,   Method: Composition-based stats.
 Identities = 88/434 (20%), Positives = 146/434 (33%), Gaps = 32/434 (7%)

Query: 2   LHPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQ-----RLPGTLGIAQD-- 54
           LH R     LL   A +IG  + +  IV  +   +   L          P  LG  Q   
Sbjct: 11  LHQRYLAKWLLI--AGSIGAVAGVGAIVFYEAIHLFTYLFLNLGAGFHPPEALGEGQPVV 68

Query: 55  ----SPLWIIGVLTLTGIAVGLVIRFSQGHA---GPDPACEPLIGAPVPPSALPGL--IV 105
                   I  V TL G+  GL++      A   G D A +          A   L  I+
Sbjct: 69  TEISRRWMIPVVTTLGGLLSGLIVFKFAPEAEGHGTDAAIDAFHHKEGIIRARVPLVKII 128

Query: 106 ALILGLAGGVSLGPEHPIMTVNIALAVAIGARLLPRVNRMEWTIL-ASAGTIGALFGTPV 164
           A  + +  G S G E P   +       +G  L          +       IGA+F  P+
Sbjct: 129 ASAITIGSGGSAGREGPTAQIAAGFGSIMGQLLKLNTRDRCIALATGIGAGIGAIFKAPL 188

Query: 165 AAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFH--PHFSLPIAHYGQMEMTD 222
             AL+ ++ L           L    +A+  G      +    P F     +    +   
Sbjct: 189 GGALLSTEILYLEGFE--VQALVPSFIASLIGYTIFASYAGYMPVFGWMSQNI-AFDPVT 245

Query: 223 ILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFK 282
           +L  A++  +    G++             ++  P  +    G +L  +  +  P  L  
Sbjct: 246 LLYYALLGVLCGLIGILYTKTFYATRNFFKKINLPKWLKPAAGGLLVGIMGLFLPQVLGM 305

Query: 283 GLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHE- 341
           G   +Q  + N+        LL   K+ A  +   SG  GG   P +F+G  +G  L + 
Sbjct: 306 GYGWLQLGMLNKPLPLDIVVLLIFAKILATSLTIGSGGSGGVFAPGLFIGGMVGTALWQL 365

Query: 342 ------HVPAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAW 395
                 H+PA P    V   +  +   V       +FM   +  + T+L    I +  A+
Sbjct: 366 LHGMVGHLPASPQPFIVVGMM-ALFGAVAHAPLAVMFMVGEMTGSYTMLVPAMIAVGIAY 424

Query: 396 LLLAGKPMMMVNRP 409
           +L+    +     P
Sbjct: 425 VLVGNNTIYESQVP 438


>UniRef50_C1F0W1 Chloride transporter, ClC family n=1 Tax=Acidobacterium capsulatum
           ATCC 51196 RepID=C1F0W1_ACIC5
          Length = 572

 Score =  121 bits (303), Expect = 5e-26,   Method: Composition-based stats.
 Identities = 77/414 (18%), Positives = 135/414 (32%), Gaps = 24/414 (5%)

Query: 6   ARTMLLLSLPAVAIGIASSLILIVVMKIAS----VLQNLLWQRLPGTLGIAQDSP----- 56
            R  L   + AV +GI  +   +    +      +    +   LP  +  +         
Sbjct: 6   ERVELRRVVDAVVLGIVGAAAALAFHWMLQFCSWLFLRHIAGYLPPDIAGSIAPHSVAVP 65

Query: 57  ---LWIIGVLTLTGIAVG-LVIRFSQGHAGPDPACEPLI----GAPVPPSALPGLIVALI 108
               WI    T+ G+  G LV  F+    G                +     P  +VA  
Sbjct: 66  HWNWWIPVATTVGGLISGALVFTFAPEAEGHGTDTVVNAFHRKAGVIRARVAPLKMVASA 125

Query: 109 LGLAGGVSLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAA 167
           + +  G S G E P   +                  R    ++  A  + A+F +P+  A
Sbjct: 126 ITIGSGGSAGREGPTALIAAGFGTLYAKLFKRSDQERRFLILVGMAAGLSAVFRSPIGTA 185

Query: 168 LIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFH--PHFSLPIAHYGQMEMTDILS 225
           +   + L  + E      L   L+A+       G+FF   P F +P  H  Q +      
Sbjct: 186 IFAVEVLYSAMEFE-SHILIYTLLASVVAYAVNGIFFGLQPLFHVPA-HLLQPDYRAYPW 243

Query: 226 GAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLD 285
              +   +     +       +  + H +  P +     G +   L  +  P  L  G  
Sbjct: 244 YVFLGLASGIVAAILPMVFYGMRDLFHAIPCPRIFKPAIGGLCVGLIALYWPQVLGGGYG 303

Query: 286 EMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPA 345
            MQ M             L  +K+ +L    +SG  GG   P++F+G  LG +L      
Sbjct: 304 WMQ-MSIGGFLPLDILIALLFLKMLSLSFTVSSGGSGGVFAPSLFIGAMLGGILAAAFHE 362

Query: 346 VPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLA 399
            PAA      +  +     R    ++ M   +     LL    + ++ A+LL +
Sbjct: 363 -PAAGFAIVGMAAVFGAAARVPMATILMVCEMTGGYQLLVPAGLAVILAFLLQS 415


>UniRef50_A4GJ08 Putative CBS:IMP dehydrogenase/GMP reductase:voltage-gated
           Cl-channel n=1 Tax=uncultured marine Nitrospinaceae
           bacterium RepID=A4GJ08_9DELT
          Length = 584

 Score =  118 bits (296), Expect = 3e-25,   Method: Composition-based stats.
 Identities = 69/385 (17%), Positives = 135/385 (35%), Gaps = 20/385 (5%)

Query: 12  LSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGI-AQDSPLWIIGVLTLTGIAV 70
           + L A  IG  + L   +  ++    + +        +GI     PL +  +  + GI  
Sbjct: 22  MLLLAAVIGFLAGLASTLFRRLIEFFEVIFSADGLVFIGITGTTVPLLLPLMPMIGGIIT 81

Query: 71  GLVIRFSQGHAGPDPA-----CEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMT 125
           G++  F       +          L    +    L        L +  G S G E P + 
Sbjct: 82  GVICHFFPDAVKENGVHRVMHAVALKAGKIRKRTLLTCSTTSALTIGSGGSAGREGPTVQ 141

Query: 126 VNIALAVAIGARLLPRVNRMEWTILASAGTIGAL-FGTPVAAALIFSQTLNGSSEVPLWD 184
           +  A+  A+G        R++  +   A    A  F  P+A  L   + +  +  +  + 
Sbjct: 142 IGSAVGSALGNMFHLSHERIQVLVGCGAAAGIAASFNAPLAGVLFALEIILTNFTIHTFS 201

Query: 185 RLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCL 244
                ++A+  G  T         +  +  +  +  ++I+    +  +      +  +  
Sbjct: 202 ---PIVVASVIGTATGRAMEGNQITFHVPVHELVSYSEIVFYLFLGILCGVVSKLFTFAY 258

Query: 245 PRLHAMM--HQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYF 302
            + H +          L   +GG I+G + ++  P  L  G D M++   N        F
Sbjct: 259 FKAHDIFDKKVKLPKPLKPALGGLIVGFIAIL-FPAVLGNGYDFMEK-ALNGELFWGLAF 316

Query: 303 LLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLV 362
           +L  +K+ +      SG  GG   P++F+G  LG      V  +  + T S     +V  
Sbjct: 317 VLIFLKIISTSATLGSGGLGGVFAPSLFIGAMLGSAYGTLVHTINPSFTASPETYALV-- 374

Query: 363 VTRDGWLSLFMAAVVVPNTTLLPLL 387
               G  ++  A +  P T +L L 
Sbjct: 375 ----GMGAVAGAVMQAPLTNILMLF 395


>UniRef50_UPI0001972FFA chloride channel protein EriC n=1 Tax=Clostridium sp. M62/1
           RepID=UPI0001972FFA
          Length = 418

 Score =  118 bits (296), Expect = 3e-25,   Method: Composition-based stats.
 Identities = 62/357 (17%), Positives = 133/357 (37%), Gaps = 15/357 (4%)

Query: 58  WIIGVLTLTGIAVGLVIRFSQ--GHAGPDPACEPL-IGAPVPPSALPGLIVALILGLAGG 114
           W I  L +TG+ +  +    +   + G +   E +   + +     P + +  +L    G
Sbjct: 54  WSIYFLPVTGLLIVWIYHILKEDKNRGTNMVIESIYTNSDISLGMAPAVFLGTVLTHFSG 113

Query: 115 VSLGPEHPIMTVNIALAVAIGARLLPRVNRMEWTI-LASAGTIGALFGTPVAAALIFSQT 173
            S G E   + +  ++   IG  +       +  +    +G   ALFGTP+AAA+   + 
Sbjct: 114 GSAGREGAALQMGGSIGNQIGKLMKLDEKDKKIAVMCGMSGAFAALFGTPMAAAVFSMEV 173

Query: 174 LNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIA 233
           +  S  V  +  L   + +A  GA  +        + PI    +  +   L   ++  + 
Sbjct: 174 I--SIGVMYYAALVPCVFSAFIGAAVSSHLGLKAEAFPIGEIPEFGLKMALLIIVLGLLC 231

Query: 234 IAAGMVAVWCLPRLHAMMHQ-MKNPVLVLGIGGFILGILGVIGGPVSL-FKGLDEMQQMV 291
                +    L R   +  +    P   +  GGF++ +L ++ G +     G+  ++Q  
Sbjct: 232 ALVSELFCIVLHRTARIYEKYFPTPNKRVIAGGFLVIVLTILVGNIDYNGSGIHLIEQCF 291

Query: 292 ANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAIT 351
             +    +  +     K+    V   +GF+GG I P   +G   G      +   P  + 
Sbjct: 292 EGEVRYEAFLW-----KILFTAVTLEAGFKGGEIVPTFCIGATFGCTFA-MLTGQPHGLM 345

Query: 352 VSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNR 408
            +C +L + + VT     +L +   +     + P   + +  ++ L     +    +
Sbjct: 346 AACGMLALFVGVTNCPISTLLIGFEMFGYEAM-PYFVLSIAVSFTLSGYYGLYSSQK 401


>UniRef50_Q1N3I5 Chloride channel, putative n=1 Tax=Bermanella marisrubri
           RepID=Q1N3I5_9GAMM
          Length = 590

 Score =  117 bits (294), Expect = 6e-25,   Method: Composition-based stats.
 Identities = 71/408 (17%), Positives = 139/408 (34%), Gaps = 23/408 (5%)

Query: 7   RTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLT 66
           +  L + L    +G+ S++   + +     L  +L   +         S  WI+ V  + 
Sbjct: 29  KNALFVVLFGSVVGVVSAIFADLFVYGFKYLNQIL--NISAASQHESISFWWILLVPCIG 86

Query: 67  GIAVGLVIRFS----QGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHP 122
           G+ VGL  R+             A   L  + VP  +     +A  + L  G S+G   P
Sbjct: 87  GLVVGLFNRYINPDKPQGPPDVIAAAQLGHSQVPFKSGMSTALASFMSLGSGASVGGYGP 146

Query: 123 IMTVNIALAVAIGARLLPRVNRMEWTILASAGTIGALFGT--PVAAALIFSQTLNGSSEV 180
           I+ +   L VA           +    +              P+A      + +     +
Sbjct: 147 IVHLGATLGVAFRKFAYGGGGHIANIGIGCGVAGAIAAAFNAPLAGMFFAHEVVLRHYSL 206

Query: 181 PLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVA 240
                     ++A  G + T +         I   G +   +  S  ++        +V 
Sbjct: 207 ---RAFAPITVSATMGYIVTAVILERPPLFQIDQIGHLNAWEYSSFMLIGVTGAMLAVVF 263

Query: 241 VWCLPRLHAMMHQMKNP-VLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTS 299
           +  L +   +   +  P  L   + GF LG++  +  P  L  G   +Q  +  ++    
Sbjct: 264 MRTLLKSQKIAQGLNMPNTLKPALAGFALGLVA-LQLPELLGLGTALLQSAMIPESIEAP 322

Query: 300 DYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHV-PAVPAA-----ITVS 353
              +L V KL    +    GF GG   P++ +GV  G ++   + P +P A     +   
Sbjct: 323 QMAMLLVGKLVVTAMCLGFGFVGGVFSPSLVIGVLFGSLVGLVLAPIMPGAADSLGVFAI 382

Query: 354 CAILGIVLVVTRDGWLSLFMAAVVVPN----TTLLPLLCIVMLPAWLL 397
           C +  +   V      ++ +   +  N    T +L  +    L ++ L
Sbjct: 383 CGMAAVTTAVIGAPISTILIILELTRNYELTTAVLLSVVFSNLVSYRL 430


>UniRef50_Q8RXR2 Chloride channel protein CLC-f n=18 Tax=Magnoliophyta
           RepID=CLCF_ARATH
          Length = 781

 Score =  117 bits (292), Expect = 9e-25,   Method: Composition-based stats.
 Identities = 74/420 (17%), Positives = 142/420 (33%), Gaps = 38/420 (9%)

Query: 12  LSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLP--GTLGIA----QDSPLWIIGVLTL 65
           L L    IG+A+ + +    K   V+    W   P  G   +      D+   I+ +   
Sbjct: 131 LLLIGCLIGVAAGICVAGFNKGVHVIHEWAWAGTPNEGAAWLRLQRLADTWHRILLIPVT 190

Query: 66  TGIAVGLVIRFSQGHAGPDPACEPLIGAPVPPSALPGL-----IVALILGLAGGVSLGPE 120
            G+ VG++    +     D   +           L G+      +   + L  G SLGPE
Sbjct: 191 GGVIVGMMHGLLEIL---DQIRQSNSSQRQGLDFLAGIYPVIKAIQAAVTLGTGCSLGPE 247

Query: 121 HPIMTVNIALAVAIGARLLP-RVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSE 179
            P + +  + A      +   R  R+  T   +A  I + F   VA      +T+     
Sbjct: 248 GPSVDIGKSCANGFALMMENNRERRIALTAAGAASGIASGFNAAVAGCFFAIETVLRPLR 307

Query: 180 VPLWDRLFA--PLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAG 237
                       ++A+   +  +        +  +  Y      ++    I+  +  A  
Sbjct: 308 AENSPPFTTAMIILASVISSTVSNALLGTQSAFTVPSYDLKSAAELPLYLILGMLCGAVS 367

Query: 238 MVA----VWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMV-- 291
           +V      W       +  +   P +V    G +   +  +  P  L+ G   +++++  
Sbjct: 368 VVFSRLVTWFTKSFDFIKDKFGLPAIVCPALGGLGAGIIALKYPGILYWGFTNVEEILHT 427

Query: 292 ANQAFSTSDYFL--LAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLH--------E 341
              A +   + L  LA  K+ A  +   SG  GG   P++ +G A+G +           
Sbjct: 428 GKSASAPGIWLLAQLAAAKVVATALCKGSGLVGGLYAPSLMIGAAVGAVFGGSAAEIINR 487

Query: 342 HVP-----AVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWL 396
            +P     A P A  +      +  + +      L +  +      LLPL+  V L  W+
Sbjct: 488 AIPGNAAVAQPQAYALVGMAATLASMCSVPLTSVLLLFELTKDYRILLPLMGAVGLAIWV 547


>UniRef50_B4CXW5 Chloride channel core n=1 Tax=Chthoniobacter flavus Ellin428
           RepID=B4CXW5_9BACT
          Length = 597

 Score =  116 bits (290), Expect = 2e-24,   Method: Composition-based stats.
 Identities = 74/410 (18%), Positives = 146/410 (35%), Gaps = 25/410 (6%)

Query: 1   MLHPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTL-GIAQDSPLWI 59
           ++ P    + L    A  IG A +   +   K+  ++     Q+  G +       PL  
Sbjct: 19  IIRPNELQVTLFW--AGVIGFAGACASVAFRKLTGLVHYAFTQQYSGLVESFEHLRPLQR 76

Query: 60  IGVLTLTGIAVGLVIRFS-----QGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGG 114
           + V  + G+  GL I        +  +        L    +   +     ++ +  +A G
Sbjct: 77  LYVPAIGGVLAGLTIFLGVRWGRRRSSTDYMEAIVLGDGIISFRSSIVKSLSAMFSIASG 136

Query: 115 VSLGPEHPIMTVNIALAVAIGA-RLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQT 173
            S+G E P++ ++  +A  IG  R  P +         +A  I + +  P+  AL  ++ 
Sbjct: 137 ASIGREGPLVQLSSMIASLIGRWRKTPTLQLRLLVACGAAAGIASAYNAPIGGALFVAEI 196

Query: 174 LNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIA 233
           +  S  +   +     + ++    LT           P+     + +        +  + 
Sbjct: 197 ILQSLAM---ESFGPLVFSSVVSTLTVRQLLG---EQPLYEIASVHLGSNWEILPLMLLG 250

Query: 234 IAAGMVAVWCLP---RLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQM 290
           + AG+ A W L        M  ++  P  V    G ++  L  I  P     G   + ++
Sbjct: 251 LVAGLFAPWFLRLLRASERMFSKLALPTYVRLGLGGLIVGLLAIWQPEVCGNGYSVVNEI 310

Query: 291 VANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALG-LMLHEHVPA---- 345
           +       +  F+L + KL A      SG  GG   P +FVG  LG L +H   P     
Sbjct: 311 LHGNLLWQALVFIL-LFKLIATAATFGSGAVGGVFTPTLFVGACLGDLAVHAAQPLWLGT 369

Query: 346 -VPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPA 394
            +   + V   +   +   T    +++ M   +  +  L+  L +  + A
Sbjct: 370 PLNPQVFVVIGMGAFLAATTHAPIMAIIMLFELTLDYQLILPLMLACVIA 419


>UniRef50_B8HWS8 Chloride channel core n=6 Tax=Bacteria RepID=B8HWS8_CYAP4
          Length = 640

 Score =  115 bits (288), Expect = 3e-24,   Method: Composition-based stats.
 Identities = 70/354 (19%), Positives = 130/354 (36%), Gaps = 22/354 (6%)

Query: 50  GIAQDSPLWIIGVLTLTGIAVGLVIRFSQGHAGPDPACEPLIGAPVPPSALPGL-IVALI 108
            IA      +  V TL G+ VGL+  + +       A      +       P + + A  
Sbjct: 75  AIAPWGAWTLALVPTLGGVVVGLMRWWLRDFGPGISAMVTTQASEPIALVRPAIKMTAAS 134

Query: 109 LGLAGGVSLGPEHPIMTVNIALAVAIGARLLPRVNRMEWTILASAGTIGAL-FGTPVAAA 167
           + L  G SLGPE P + +   + + +   L     R    + A A    A  F  P+A  
Sbjct: 135 VSLGTGASLGPEGPSVEIGANIGMVLAQMLRVSQERRRLLLGAGAAAGLAAGFNAPIAGV 194

Query: 168 LIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGA 227
            +  + +  ++       + A L++A   AL T +      +  +  Y      ++    
Sbjct: 195 FLSLELVLSTTFAT--TTVGAVLLSAVVAALITQIGLGSQPAFALPVYEVRSPWELPLYV 252

Query: 228 IVAAIAIAAGMVAVWCLPRLHAMM--------HQMKNPVLVLGIGGFILGILGVIGGPVS 279
            +  +A    ++ V  +     +            K P+ +  + G     L  +  P  
Sbjct: 253 GLGILASGISLIFVEAIKFCQQLFEGQLPGLGWVGKIPLSLQPVIGGGCVGLVALAVPQV 312

Query: 280 LFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLML 339
           L  G + ++ ++ N  FS     LL ++KL    ++  SG  GG   P++F+G  LG   
Sbjct: 313 LGIGYETVEAVLRNVVFSLPLLLLLLLVKLMMTAISLGSGLVGGIFAPSMFLGATLGAAY 372

Query: 340 HEHVPAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLP 393
            +          V   +L   L +      ++   A V+  +T  PL  I++L 
Sbjct: 373 GQ----------VMALLLPPGLAIAAPPAYAMVGMAAVLAGSTRSPLTAILLLF 416


>UniRef50_Q04PD3 Chloride channel protein n=4 Tax=Leptospira RepID=Q04PD3_LEPBJ
          Length = 626

 Score =  115 bits (288), Expect = 3e-24,   Method: Composition-based stats.
 Identities = 75/448 (16%), Positives = 151/448 (33%), Gaps = 55/448 (12%)

Query: 12  LSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDS---------------- 55
           L    +  GI S L   +  +I +V    L+      L +   S                
Sbjct: 17  LYFYCILTGIVSGLGAFLFSRILAVC-EYLFLDRAAGLSLPHASGEFLIDSNDTLHWGIP 75

Query: 56  ------PLWIIGVLTLTGIAVGLVI-RFSQGHAGPDPACEPLIGAPVPPSALPGLIV--- 105
                 P  +  +  + G+  G ++ RFS    G                  P + +   
Sbjct: 76  FSDEYRPWVLFFLPIIGGLLTGWIVNRFSPESGGTGSDAMIDSFHNQEGRMNPVVSLVKS 135

Query: 106 -ALILGLAGGVSLGPEHPIMTVNIALAVAIGARLLPRVNRMEWTIL-ASAGTIGALFGTP 163
            A +  LA G S G E PI  +       +   L          +L  +AG +GA+F  P
Sbjct: 136 IATVFTLASGGSGGKEGPISQIGAGFGSLLATLLKAGARARRTLLLAGTAGGLGAIFHAP 195

Query: 164 VAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDI 223
           +  AL   + +    E    D L   ++++ +  L        +    +     +  TD+
Sbjct: 196 LGGALTSVEMI--YREDIESDSLIPCIISSVSAYLVYSGLNGFNTVYRVTGTEFLRYTDL 253

Query: 224 LSGAIVAAIAIAAGMVAVWCLPRLHAM-MHQMKNPVLVLGIGGFILGILGVIGGPVSLFK 282
           +    +  +    G + +    ++     H   +P+L   +GG  +GI+G+   P ++  
Sbjct: 254 IFYLGLGVLCFLCGDIFIRIFRKVQNFSAHLKISPILKPALGGIFVGIVGLF-LPETIGT 312

Query: 283 GLDEMQQMV-----------------ANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRI 325
           G   +Q  +                 ++  +  + +F+LA +K+        +G   G  
Sbjct: 313 GAGILQVALDGKDPVGASGIFSSVFQSSGLWLVALFFILAGVKILTTSFTVGTGGSAGMF 372

Query: 326 FPAVFVGVALGLMLHEH-----VPAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPN 380
            P++F+G  LG  +         P +     +   +      V       + M   ++ +
Sbjct: 373 GPSLFIGGMLGGGVGTFAKIFVYPDLSVTSFILVGMGAFYAGVASAPIAGMIMICEMIGS 432

Query: 381 TTLLPLLCIVMLPAWLLLAGKPMMMVNR 408
             LLP L +V +  ++L     +    +
Sbjct: 433 YMLLPPLMVVSILTFVLSHKLSLYRAQK 460


>UniRef50_Q8GX93 Chloride channel protein CLC-e n=7 Tax=Magnoliophyta
           RepID=CLCE_ARATH
          Length = 710

 Score =  115 bits (288), Expect = 3e-24,   Method: Composition-based stats.
 Identities = 69/435 (15%), Positives = 150/435 (34%), Gaps = 39/435 (8%)

Query: 16  AVAIGIASSLILIVVMKIASVLQNLLWQRLP--GTLGIAQDS----PLWIIGVLTLTGIA 69
           A  +G+ + + +++      +L++  W  +P  G   + +       L +I V T+ G+ 
Sbjct: 80  ACLVGVLTGVSVVLFNNCVHLLRDFSWDGIPDRGASWLREAPIGSNWLRVILVPTIGGLV 139

Query: 70  VGLVIRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIA 129
           V ++ +  +            +             VA  + L  G SLGPE P + +  +
Sbjct: 140 VSILNQLRESAGKSTGDSHSSLDRVKAVLRPFLKTVAACVTLGTGNSLGPEGPSVEIGAS 199

Query: 130 LAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFA 188
           +A  + +                SA  I + F   VA      +++   S          
Sbjct: 200 IAKGVNSLFNKSPQTGFSLLAAGSAAGISSGFNAAVAGCFFAVESVLWPSSSTDSSTSLP 259

Query: 189 -----PLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWC 243
                 +++A   ++ + +      +  +  Y      ++    ++ A+     +    C
Sbjct: 260 NTTSMVILSAVTASVVSEIGLGSEPAFKVPDYDFRSPGELPLYLLLGALCGLVSLALSRC 319

Query: 244 LPRLHAMMHQMKN-----PVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQ---- 294
              + + +  +         +   +GG  +GI+ ++  P  L+ G   +  ++  +    
Sbjct: 320 TSSMTSAVDSLNKDAGIPKAVFPVMGGLSVGIIALVY-PEVLYWGFQNVDILLEKRPFVK 378

Query: 295 AFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPA---VPAAIT 351
             S      L  +K+AA     ASG  GG   P++F+G A G+   + +           
Sbjct: 379 GLSADLLLQLVAVKIAATAWCRASGLVGGYYAPSLFIGGAAGMAYGKFIGLALAQNPDFN 438

Query: 352 VSCAILGIVLVVTRDGWLSLFMAAVVVPNTT-------------LLPLLCIVMLPAWLLL 398
           +S   +         G  +       VP T              +LPLL  V + +W+  
Sbjct: 439 LSILEVASPQAYGLVGMAATLAGVCQVPLTAVLLLFELTQDYRIVLPLLGAVGMSSWI-T 497

Query: 399 AGKPMMMVNRPKQQP 413
           +G+      R  ++ 
Sbjct: 498 SGQSKRQETRETKET 512


>UniRef50_C6C168 Chloride channel core n=1 Tax=Desulfovibrio salexigens DSM 2638
           RepID=C6C168_DESAD
          Length = 590

 Score =  114 bits (286), Expect = 5e-24,   Method: Composition-based stats.
 Identities = 75/400 (18%), Positives = 151/400 (37%), Gaps = 26/400 (6%)

Query: 2   LHPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIG 61
            +PR +  +LL   +VAIG+A++    +   +    Q+  W      L +A +SP W++ 
Sbjct: 17  FNPRVQ-YVLLMSFSVAIGMAAAGGAFLFRWLIENFQHFFWASGNSFLDMAANSPWWLVL 75

Query: 62  VL-TLTGIAVGLVIRFSQGHA-----GPDPACEPLIGAPVPPSALPGLIVALILGLAGGV 115
            L  + G+  G++I      A             + G  +         +A  L +  G 
Sbjct: 76  FLPCIGGLIAGVIITNWAPEAQGPGVPEVIKALAVRGGVIRHRITFLKALATSLLIGCGA 135

Query: 116 SLGPEHPIMTVNIALAVAIGARLLPRVNRMEWTILASAGTIGAL-FGTPVAAALIFSQTL 174
           S+G E P++ +  +L  +         + +   + + A    A  F  P+   L   + L
Sbjct: 136 SVGREGPVVQIGASLGSSAARIFRLDPSMLPVCVASGAAAGIAATFNAPLTGTLFAIEIL 195

Query: 175 NGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAI 234
              +E+     +   ++A+   +  +  F+    +     +      +++   ++  +A 
Sbjct: 196 LLDTEMSY---VSHIIVASVTASALSKFFWGDFPTFDAPKFIFSNFEELIIFFLLGILAG 252

Query: 235 AAGMVAVWCLPRLHAMMHQMKNPVLVL-GIGGFILGILGVIGGPVSLFKGLDEMQQMVAN 293
              +  V  +        Q+  P  V  G+GG ILG +  +  P  L  G + +  M   
Sbjct: 253 LVSIAFVKMIRLCEFTFDQIPVPGWVKPGLGGLILGAIA-LKIPAVLGVGYEAVN-MGLT 310

Query: 294 QAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVS 353
                    +L   KL A  +   SG  GG   P++ +G ALG+ +   +  +   + ++
Sbjct: 311 GVLPLDLAIILLGAKLVATSLCIGSGMSGGIFAPSLVLGAALGVSVSSTINMIFPELALT 370

Query: 354 CAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLP 393
                        G  +L     VV  TTL P+  ++ + 
Sbjct: 371 ------------HGQYALVGMGTVVAGTTLAPITAVLTVF 398


>UniRef50_C0QAG4 EriC1 n=1 Tax=Desulfobacterium autotrophicum HRM2
           RepID=C0QAG4_DESAH
          Length = 576

 Score =  114 bits (285), Expect = 6e-24,   Method: Composition-based stats.
 Identities = 69/403 (17%), Positives = 134/403 (33%), Gaps = 28/403 (6%)

Query: 5   RARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLT 64
           R    LLL    V +G++S L  I + +    +   L                W   +  
Sbjct: 17  RMDDRLLLISIGVIVGLSSGLAAIGLNRSLVFMLEGLHH---------LRHQWWAFLLPA 67

Query: 65  LTGIAVGLVIRFSQGHA-----GPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGP 119
              +A  L +                      G  +   +    +++  L +  G S GP
Sbjct: 68  AGAMASALFLDKIMKEGAGHGVPEVIYSVSRYGGLLRFRSSFSRLISSCLTIGSGGSAGP 127

Query: 120 EHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSS 178
           E P++    A+   I     L    R       +AG I  +F  P+   +   + + G  
Sbjct: 128 EAPVVMSGAAIGSTIARFFNLNDRQRTTLVGCGAAGAIAGIFNAPLTGIIFTMEIILGEW 187

Query: 179 EVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGM 238
            +     +    +A+ AGA  + L      +   + +  +   D+ +   +A +A  A +
Sbjct: 188 SM---VNIIPIAVASVAGAEVSRLLQGNSIAFESSGF-HITGVDLFASLGLAVVAAFASI 243

Query: 239 VAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFST 298
           +    L R+H +  +++ P+ V    G     L     P  L +G   +  M+       
Sbjct: 244 LLTRSLRRMHGVSAKVRVPLWVRAAIGGCAVGLLGYVVPEVLGEGYHSIHAMIQGVFKGG 303

Query: 299 SDYFLLAVI-KLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVP-------AVPAAI 350
                LA   K+ A  +    G  GG   P + +G   GL  H  +         V    
Sbjct: 304 IGIAALAFFAKILATSLTLGWGGSGGVFAPCLVIGSFAGLAFHRLLVFGFPSAMLVNEGC 363

Query: 351 TVSCAILGIVLVVTRDGWLSLFMAAVVV-PNTTLLPLLCIVML 392
                + G++  + +     +F+   +      +LPL+ +  +
Sbjct: 364 FALLGMAGLISGILQAPLTGIFLILEITGSYEVMLPLIIVSAI 406


>UniRef50_A3CW01 Cl-channel, voltage-gated family protein n=3 Tax=Methanomicrobiales
           RepID=A3CW01_METMJ
          Length = 754

 Score =  114 bits (285), Expect = 6e-24,   Method: Composition-based stats.
 Identities = 69/426 (16%), Positives = 133/426 (31%), Gaps = 45/426 (10%)

Query: 9   MLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPG-------------TLGIAQDS 55
              + L AV +G+ + L  +   +   +      + + G                   D+
Sbjct: 136 YRRVILIAVIVGLIAGLGALFFFEGLKLGTAFFMEGIVGFQIPKEGQNLQDIAQWAPPDN 195

Query: 56  PLWIIGVLTLTGIAVGLVIRF----SQGHAGPDPACEPLIGAPVPPSALPGLIVALILGL 111
              I+ V+   G+  GL++      ++GH              V         V  +L +
Sbjct: 196 LWMILPVICFGGLLSGLLVYTFAPEAEGHGTDAAIKAFHGEGRVRWRVPLVKAVTAVLTI 255

Query: 112 AGGVSLGPEHPIMTVNIALAVAIGARLLPRVNRMEWTIL-ASAGTIGALFGTPVAAALIF 170
           + G S G E P   ++          L          I       IG +F  P+  A++ 
Sbjct: 256 STGGSAGREGPTAQMSAGFGSIAADLLGLSARERRLAIATGVGAGIGTIFMAPLGGAILA 315

Query: 171 SQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLF--FHPHFSLPIAHYGQMEMTDILSGAI 228
           ++ L         + +    +A+  G    GL   F P F           ++ I    +
Sbjct: 316 AEILYRQDFET--EAIVPAFLASVIGYAIFGLVEGFEPVFG---PGVTSWNVSQIPFFIL 370

Query: 229 VAAIAIAAGMVAVWCL----PRLHAMMHQMKNPVLVLGIGGFILGIL-----------GV 273
           +  ++ A G++ +            +  ++K P     + G  L                
Sbjct: 371 LGVVSTAIGLIYINTFYGTNRIFKKVFSRLKIPNHFKPLAGAFLTGTFVLALAALSPEAA 430

Query: 274 IGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGV 333
           I G  SL  G     Q+             L   K+    +   SG  GG   P + +G 
Sbjct: 431 IVGLGSLGTGYG-FAQLALYNMLPVGVLLFLPFAKILTTSLTIGSGGSGGVFAPGLVIGG 489

Query: 334 ALGLMLHEHVPAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLP 393
           A G      +      I  + ++    +V    G ++LF A    P   ++ ++ +    
Sbjct: 490 ATGGAFGSLLHLALPGIIPAESVPVFFIV----GMIALFGAISHAPIAVMIMVVEMTGDF 545

Query: 394 AWLLLA 399
           + L+ A
Sbjct: 546 SLLVPA 551


>UniRef50_C1MEP8 Voltage-gated chloride channel family protein n=4 Tax=Bacteria
           RepID=C1MEP8_9ENTR
          Length = 457

 Score =  114 bits (285), Expect = 7e-24,   Method: Composition-based stats.
 Identities = 76/360 (21%), Positives = 140/360 (38%), Gaps = 12/360 (3%)

Query: 54  DSPLWIIGVLTLTGIAVGLVIRF--SQGHAGPDPACEPLIGAP--VPPSALPGLIVALIL 109
           +S  W+I +L L G+ VGLV  +     +AG +   + +      VP   +P ++   ++
Sbjct: 49  ESHSWMIWLLPLAGLLVGLVYSWYGEPVNAGNNLIIDEIHDPRKVVPIRMVPLVLGGTLM 108

Query: 110 GLAGGVSLGPEHPIMTVNIALAVAIGARLLPRVNRMEWTIL-ASAGTIGALFGTPVAAAL 168
               G S+G E   + +  ALA  +      + +     ++   +    ++FGTP+A A+
Sbjct: 109 SHLFGASVGREGTAVQMGGALADQLTHMFKVKKDARRILLMAGMSAGFSSVFGTPMAGAI 168

Query: 169 IFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAI 228
              + L        +D LF  L+AA         +   H    I       +   LS  I
Sbjct: 169 FGMEVLAIGRI--RYDALFPCLVAAVLADQVCLAWGVHHTHYRIDFIPAFTIWSFLSVVI 226

Query: 229 VAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQ 288
             A+   AGMV      +   ++ +      +    G IL    V       + GL  + 
Sbjct: 227 AGAVFGLAGMVFSVATGKASGIVKRYIKYAPLRPFFGGILIAAAVWFIGTDRYIGLG-IP 285

Query: 289 QMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPA 348
           ++V  +AF    Y +  + K++  +V+ A+GF+GG + P  ++G  LG  L   +  +P 
Sbjct: 286 EIV--RAFKEPLYPMDFMGKMSFTIVSLATGFKGGEVTPLFYIGATLGNALAPLL-HMPF 342

Query: 349 AITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNR 408
           A       + +          + FMA  +   T +     +    A+L      +    R
Sbjct: 343 AFMAGIGFVAVFAGAANTPLATTFMAMELF-GTEMAVFSAVGCFTAYLFSGHTGIYHAQR 401


>UniRef50_Q3M8F4 Cl-channel, voltage gated n=3 Tax=Cyanobacteria RepID=Q3M8F4_ANAVT
          Length = 596

 Score =  114 bits (284), Expect = 8e-24,   Method: Composition-based stats.
 Identities = 90/410 (21%), Positives = 165/410 (40%), Gaps = 28/410 (6%)

Query: 16  AVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIR 75
           AV IG  + + ++    +  ++ +L+ + L G +G+       +  V  L G+ VGL+  
Sbjct: 5   AVLIGGGTGMGVVTFHYLIELIHHLMLENLMGAIGV--WGAWTLALVPILGGLIVGLMRW 62

Query: 76  FSQGHAGPDPACEPLI-GAPVPPSALPGL-IVALILGLAGGVSLGPEHPIMTVNIALAVA 133
            +Q       +      G+ +     P   ++A  + L  G SLGPE P + +     + 
Sbjct: 63  RTQDFGPGLSSLIAASEGSEIKGQLRPVTKMLAAAVSLGSGASLGPEGPSVEIGANFGML 122

Query: 134 IGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMA 192
           +   L + +  +       +A  + A F  P+A      + + G++           L A
Sbjct: 123 LSLILQVSQERQRLLLGAGAAAGLAAGFNAPIAGVFFALEVVMGATSFATSAVSVVLLAA 182

Query: 193 AAAGALT-TGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGM---------VAVW 242
             A  +   GL   P F+LP+          +  G  + A  ++              V 
Sbjct: 183 VVAALIAQIGLGAQPAFALPVYQVRSPLELPLYLGLGLGASLVSVAYKQSINWGKACFVG 242

Query: 243 CLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYF 302
            +P     + ++  P+  + IGGF++GI+  +  P  L  G   +Q M+ +  FS     
Sbjct: 243 SIPGFQ-FLGKIPQPIHPI-IGGFMIGIVA-LKFPQILGIGYGTVQAMLQDVKFSLDLLL 299

Query: 303 LLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCA------- 355
           +L V+KL    ++A SGF GG   PA+F+G +LG    + +  +   I    A       
Sbjct: 300 ILLVLKLLMTAISAGSGFVGGLFAPAMFLGASLGSAYAKVLTLIAPGIGEYMAAPPAYAM 359

Query: 356 --ILGIVLVVTRDGWLSLFMAAVVVPNTTL-LPLLCIVMLPAWLLLAGKP 402
             +  ++    R    S+ M   +  +  + LPL+  V L  WL+   KP
Sbjct: 360 VGMAAVLAGSVRAPLTSILMLFELTRDYRIVLPLMAAVGLSVWLVERIKP 409


>UniRef50_A7BCR6 Putative uncharacterized protein n=1 Tax=Actinomyces odontolyticus
           ATCC 17982 RepID=A7BCR6_9ACTO
          Length = 595

 Score =  114 bits (284), Expect = 9e-24,   Method: Composition-based stats.
 Identities = 68/399 (17%), Positives = 133/399 (33%), Gaps = 33/399 (8%)

Query: 39  NLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVI-RFSQGHAGP-DPACEPLI---GA 93
           + +W   P          L+++    + G+  G +I RF+    G   P     +   G 
Sbjct: 57  HGVWGWTP---------WLFLLLSPAIAGLLYGPLIQRFAPSAKGHGIPEVMLAVRRKGG 107

Query: 94  PVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARLL-PRVNRMEWTILAS 152
            +P       I+A  L +  G S G E PI+ V  +L   I + L  P    +      S
Sbjct: 108 RIPGRVAIVKILASALTIGSGGSAGREGPIVQVGASLGSTIASWLRMPVSRVVLLASCGS 167

Query: 153 AGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPI 212
           A  I A F  P+A A+   + +        +  +   +++A   ++   +       + +
Sbjct: 168 AAGIAATFHAPLAGAVFALEVILVEFTAETFGFV---VLSAVTSSVVARILQGDEMVIRV 224

Query: 213 AHYGQM-EMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPV-----LVLGIGGF 266
           A       M+DI   A +  +A   G+     L      +  +            G+ G 
Sbjct: 225 ADNLTFASMSDIWWVAFLGLVAGLCGLGFSKLLYASEDAIDWLWARTHLPEWARPGVLGL 284

Query: 267 ILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIF 326
            LG   ++  P     G   +++     ++S +    L + +          G  GG   
Sbjct: 285 ALGA-ALVAFPYMYGSGY-PLEEDAIAGSYSIAFLLALMLGRAVFTSFTIGMGGSGGVFA 342

Query: 327 PAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTT---- 382
           P +F+G   G    + +  +  +     A++G+           +    ++V  T     
Sbjct: 343 PTLFIGAMAGAAFGDVISPLSDSPVGVFAVVGMGAAFAGAARAPMTAVLIIVEMTGQFSL 402

Query: 383 ---LLPLLCIVMLPAWLLLAGKPMMMVNRPKQQPPHDNV 418
              ++  + I M  +  L          R +     D V
Sbjct: 403 ILPMMLAVVIAMGASRFLTRATIYTEKLRRRGDVLDDPV 441


>UniRef50_B9XDX3 Chloride channel core n=1 Tax=bacterium Ellin514 RepID=B9XDX3_9BACT
          Length = 614

 Score =  113 bits (283), Expect = 1e-23,   Method: Composition-based stats.
 Identities = 61/359 (16%), Positives = 129/359 (35%), Gaps = 19/359 (5%)

Query: 55  SPLWIIGVLTLTGIAVGLVIRFSQGHAGP-----DPACEPLIGAPVPPSALPGLIVALIL 109
            PL  + + T+  +  G+V+ +     G                 +P        ++ +L
Sbjct: 85  PPLERLVISTVGALLAGVVLYWGLRLVGKQGSSNILEVVVASDGRLPFRTTIVKAISSLL 144

Query: 110 GLAGGVSLGPEHPIMTVNIALAVAIGARLLPRVNRMEWTI-LASAGTIGALFGTPVAAAL 168
            +  G S+G E  I  +    A   G     +  R+   +   +A  I A +  P+A A+
Sbjct: 145 SIGSGASIGREGAITNLAATFASKWGQLCRWQPYRLRLLVACGAASGISAAYNAPIAGAV 204

Query: 169 IFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAI 228
             +  + G+  + L+      + ++   ++ +  FF       +  +    +T +    +
Sbjct: 205 FAALIVLGNFSMNLFA---PLVFSSVVASMVSRSFFGLKPWYEVTQFDFKSLTQLPWFLL 261

Query: 229 VAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGL---- 284
           +  +    G V +  L     +  ++  PV V    G        +  P     G     
Sbjct: 262 LGIVTGVMGAVFLKMLAWSEEIFKRVPAPVYVRLALGGFFAGCLAMAFPQVWGNGYGITN 321

Query: 285 DEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVP 344
             + +   N++        L + KL A +    SG  GG   P +F+G  LG +    + 
Sbjct: 322 RILHEQFLNESSPLIFLIGLFLAKLLATLATVGSGAVGGVFTPTLFLGAGLGYIFGAGLH 381

Query: 345 ------AVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLL 397
                  +P ++     +  ++   TR   L++ M   V  N +L+P L +  + + L+
Sbjct: 382 DAGQGMVLPTSVFTLVGMGSMLAATTRSPLLAMIMVFEVSLNYSLMPPLMLACVVSTLM 440


>UniRef50_Q6AIP2 Related to chloride channel protein n=1 Tax=Desulfotalea
           psychrophila RepID=Q6AIP2_DESPS
          Length = 695

 Score =  113 bits (283), Expect = 1e-23,   Method: Composition-based stats.
 Identities = 71/395 (17%), Positives = 135/395 (34%), Gaps = 40/395 (10%)

Query: 21  IASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRFSQGH 80
           + + +  ++ +K+  ++Q+  +  +     I        +    + G+ VG +I  ++  
Sbjct: 34  VITGVGSVIFIKLIHLIQSFFYTGVYEK--IPFLGKWIYVVAPVIGGLLVGPLILLAKEA 91

Query: 81  AGP-DPACEP---LIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGA 136
            G   P       L G  +        IVA  + +  G S G E PI+ V  A   ++G 
Sbjct: 92  KGHGVPEVMQALVLRGGRIRGRVAAAKIVASAICIGTGGSAGREGPIIQVGAAFGSSLGQ 151

Query: 137 RL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAA 195
            L L            +A  I A F  P+A  +   + L  +  +         ++++ A
Sbjct: 152 ILKLSDERIRNLVACGAAAGIAATFNAPIAGVVFAIEVLMFNIHI---RAFGNVVISSVA 208

Query: 196 GALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMK 255
            ++ + LF     +  +  Y      +++   I+   A   G+  +  L     +     
Sbjct: 209 ASIVSRLFLGHGAAFAVPTYTMANPVELVLYFILGLTAALVGVFFIRILDVAETVFDNWD 268

Query: 256 NPVLVL-GIGGFILGILGVIGG----------------------PVSLFKGLDEMQQMVA 292
            P +    +G   LG++G+I                        P     G   +   + 
Sbjct: 269 FPQIFKPAVGAACLGVIGLIYMSFPGFVDPNATGVHGPITAAPIPHMFGTGFPFIGYALQ 328

Query: 293 NQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITV 352
            +  S     +L  +K  A      SG  GG   P++F G  LG  +          IT 
Sbjct: 329 GKG-SFWVLLMLVFLKPLATTFTLGSGNSGGVFAPSLFTGAMLGGAMGHVFLYFFPGITG 387

Query: 353 SCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLL 387
           +     +V      G  +LF A    P T +L + 
Sbjct: 388 NIGAYALV------GMAALFSATARAPLTAMLIVF 416


>UniRef50_Q316N5 CBS n=1 Tax=Desulfovibrio desulfuricans subsp. desulfuricans str.
           G20 RepID=Q316N5_DESDG
          Length = 615

 Score =  113 bits (282), Expect = 1e-23,   Method: Composition-based stats.
 Identities = 74/399 (18%), Positives = 142/399 (35%), Gaps = 18/399 (4%)

Query: 8   TMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLW-IIGVLTLT 66
           + L + L AV +G+      ++   +   +Q L +      L      P W +I      
Sbjct: 47  SHLPMLLMAVLVGVLGGYGAVLFKFVIKGVQFLFYGNTADFLEFHDSVPYWAVIAAPAAG 106

Query: 67  GIAVGLVI----RFSQGHA-GPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEH 121
           G+AVG ++    R ++GH          L    +        I A  + ++ G S+G E 
Sbjct: 107 GLAVGYLVSRFAREARGHGVPEVMEAIALHDGRIRKRVALVKIFASAISISSGGSVGREG 166

Query: 122 PIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEV 180
           PI+ +   +   +G  L + R  R       +A  I A F  PVA  L   + L G   +
Sbjct: 167 PIVQIGSGIGSTVGQMLKVGRPQRRTLVGCGAAAGIAATFNAPVAGVLFALELLLGDFGL 226

Query: 181 PLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVA 240
             +      ++++      +  +F    +  +  Y    + +      +  +  A  ++ 
Sbjct: 227 AAFS---PVVLSSVVATTISRHYFGDFPAFVVPGYEVASLWEYGIYPFLGIVCGAVAVIF 283

Query: 241 VWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSD 300
           V  L R   +   ++ P  +    G       ++  P     G   +  +          
Sbjct: 284 VTVLYRTEDLCEAVRLPDPLKACLGGAAVGCMLLWFPHVFGVGYGGIN-LALQNGLGWQM 342

Query: 301 YFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVA----LGLMLHEHVPAVPAAIT--VSC 354
             LL  +K+ A  V   SG  GG   P++F+G       G    +  P + A        
Sbjct: 343 MLLLVGVKIIATSVTIGSGGSGGVFAPSLFIGSMTGGFFGWAAGQLFPGITALPGAYALV 402

Query: 355 AILGIVLVVTRDGWLSLFMAAVVVPN-TTLLPLLCIVML 392
           A+ G+V   T     ++ +   +  +   +LPL+   +L
Sbjct: 403 AMGGLVAGTTHAPITAILIIFELTGDYQIILPLMVTCIL 441


>UniRef50_A0B965 Cl-channel, voltage-gated family protein n=3 Tax=Euryarchaeota
           RepID=A0B965_METTP
          Length = 580

 Score =  112 bits (281), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 85/414 (20%), Positives = 155/414 (37%), Gaps = 32/414 (7%)

Query: 14  LPAVAIGIASSLILIVVMKIASVLQNLLWQRL-----PGT-----LGIAQDSPLWIIG-V 62
           L A  +G  S L   +   +  +   +    L     P       + I     +  +  V
Sbjct: 6   LLAAFVGAISGLGAFIFYFLLELSTRVFLTGLDNYTPPKAGDVELVNIDFHIGMLPLPAV 65

Query: 63  LTLTGIAVGLVI-RFSQGHAGP--DPACEPLIGAPVPPSALPGLI--VALILGLAGGVSL 117
           +TL G+  GL++ +F+    G   D        A     A   ++  ++  + +  G S 
Sbjct: 66  VTLGGLLSGLIVYKFAPEAEGHGTDAVIRSFHKARGALRARVPVVKTISSAITIGSGGSA 125

Query: 118 GPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTL-- 174
           G E PI  +       +   L L   +R    +   AG IG++F +P   A+   + L  
Sbjct: 126 GREGPIAQIGAGFGSFVADLLRLSDRDRRLLVVCGVAGGIGSIFRSPFGGAMFGIEVLYK 185

Query: 175 NGSSEVPLWDRLFAPLMAAAAGALTTGLFFH-PHFSLPIAHYGQMEMTDILSGAIVAAIA 233
                  +     + ++A     + T  F   P  S PI    Q+ +   L   + A ++
Sbjct: 186 KDYEVEAIVPAFVSSIVAFVTFNVVTSYFAGIPFISPPIFKIPQLSIHSPLEFPLYAVVS 245

Query: 234 IAAGMVAVWCLPRLHAMMHQMKNPVLVLGI----GGFILGILGVIGGPVSLFKGLDEMQQ 289
           + A    V+ +   + +    K+  +   +    GG + G +G++  P  L  G   +Q 
Sbjct: 246 VLAAFFGVFYIKTFYTIRGLFKSSKIPQTLKPAFGGLLTGSIGML-LPGVLGMGYGYVQ- 303

Query: 290 MVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFV----GVALGLMLHEHVPA 345
           M  +   + S  FLL + K+AA      SG  GG   P++ +    G  +G + H+  P 
Sbjct: 304 MAIDGKLALSVIFLLILGKIAATSFTVGSGGSGGVFAPSIVIGSMVGAFIGYLFHQLFPE 363

Query: 346 --VPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLL 397
             V     V   +   +  V +    S+ M   +  +  +LP L I    A+ L
Sbjct: 364 IVVQPEAFVLIGMSAFIAAVAKTPIASILMVLEMCGSYMMLPALMISSALAYCL 417


>UniRef50_C4G8P2 Putative uncharacterized protein n=1 Tax=Shuttleworthia satelles
           DSM 14600 RepID=C4G8P2_9FIRM
          Length = 449

 Score =  112 bits (281), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 67/360 (18%), Positives = 138/360 (38%), Gaps = 11/360 (3%)

Query: 55  SPLWIIGVLTLTGIAVGLVIRFSQGH---AGPDPACEPLIGAPVPPSALPGLIVALILGL 111
           S  W+I +L L G  +        G               G  +    +P +  + I   
Sbjct: 79  SYPWLIYLLPLGGACIFFYYHLLDGDNSIGTNLVISSIQSGDHIRKRMIPAIFFSSIFSH 138

Query: 112 AGGVSLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIF 170
             G S+G E   + +  ++   +G    LPR N+    +   +    A+FGTPVAAA+  
Sbjct: 139 LLGASVGREGAALQLGGSIGYNLGKTFRLPRHNQHVMIMCGMSAVFSAVFGTPVAAAIFA 198

Query: 171 SQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFH-PHFSLPIAHYGQMEMTDILSGAIV 229
            + +  S  +  +  L   ++A+         FF  P+   P+ +  +  +   L    +
Sbjct: 199 MEVV--SVGIMHYAALVPCVVASFVARGIAIFFFRIPNAGYPLGNIPEFTLASALPVLGL 256

Query: 230 AAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQ 289
           A IA    ++      ++     ++     +  +    + +L  +      + GL  +  
Sbjct: 257 AVIAGLVSILECVSFRKVEVWSERLLANRYLRAVLLGTILLLLTLLVGKPTYNGLG-IDS 315

Query: 290 MVANQAFSTSDYFLLA-VIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPA 348
           + A  A +  D    + ++K+    ++ A+G++GG I P +F+G ALG      V   P 
Sbjct: 316 IAAAAAGNAPDLLWYSFLLKILFTALSLAAGYKGGEIVPTLFIGSALGYAFGSLVGFFP- 374

Query: 349 AITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNR 408
           A+  S A+  +   VT     S+ +  + +     LP   + +  ++   +   +    +
Sbjct: 375 ALCSSVAVGALFCGVTNSPITSI-ILCIELFGIRGLPYYVLAIAISYAASSYYGLYSAQK 433


>UniRef50_B2V3B5 Voltage gated chloride channel family n=9 Tax=Clostridiales
           RepID=B2V3B5_CLOBA
          Length = 418

 Score =  112 bits (280), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 60/357 (16%), Positives = 133/357 (37%), Gaps = 15/357 (4%)

Query: 58  WIIGVLTLTGIAVGL---VIRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGG 114
           WII +L L G  +     +++                   VP S  P + ++ ++    G
Sbjct: 55  WIIFMLPLGGALIICLYKILKLGSNIGTNLVIDSIRTDGKVPFSMSPLIFISTVITHLFG 114

Query: 115 VSLGPEHPIMTVNIALAVAIGARLLPRVNRMEW-TILASAGTIGALFGTPVAAALIFSQT 173
            S G E   + +  ++   +G  L      M   T+   +G   ALFGTP+ A     + 
Sbjct: 115 GSAGREGAALQLGGSIGSQVGKILHLDEKDMHLITLCGMSGVFSALFGTPLTATFFAMEV 174

Query: 174 LNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIA 233
           +  S  +  +      ++++      + LF        I     +   +I+  AI+ A+ 
Sbjct: 175 I--SVGIIYYSSFIPCIVSSIVAYKVSLLFGLEPVRFNINVIPNISTENIIKVAILGALC 232

Query: 234 IAAGMVAVWCLPRLHAMMHQM-KNPVLVLGIGGFILGILGVIGGPVSL-FKGLDEMQQMV 291
               ++    L + +  +  + KN  L +  GG  +  L  I G       G++ +   +
Sbjct: 233 ALVSIIFCETLHKTNKFLSNLIKNDYLRIICGGLAIVALTFIVGSRDYNGAGMNIIANAI 292

Query: 292 ANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAIT 351
             QA   +      ++K+    +  + G++GG I P  F+G   G ++   +   P  + 
Sbjct: 293 NGQAKPEAF-----ILKIIFTAITISVGYKGGEIVPTFFIGATFGCVVGGLIGLDPR-LG 346

Query: 352 VSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNR 408
            +  ++ +   V      S+ ++  +  +  L+    +    +++L     +    +
Sbjct: 347 AAIGLVALFCGVVNTLITSVILSIELFGSGALILF-AVACGVSYMLSGYFSLYSSQK 402


>UniRef50_D1PN62 Chloride transporter, chloride channel family n=1
           Tax=Subdoligranulum variabile DSM 15176
           RepID=D1PN62_9FIRM
          Length = 429

 Score =  112 bits (280), Expect = 3e-23,   Method: Composition-based stats.
 Identities = 61/347 (17%), Positives = 127/347 (36%), Gaps = 13/347 (3%)

Query: 58  WIIGVLTLTGIAVGLVIR-FSQGHAGPDPACEPLIGAP--VPPSALPGLIVALILGLAGG 114
           W++ +L + G+ +  + R F     G        +     +     P +  + +     G
Sbjct: 55  WLLYLLPVGGLVIVFLYRHFDPQGGGSTNQVFAAVRERKVLTLRTAPLIFFSTVTTHLLG 114

Query: 115 VSLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQT 173
            S G E   + +  +++   G  L L R +    T+   AG   A+FGTP+AA +   + 
Sbjct: 115 GSSGREGAALLLGGSVSGQFGRLLRLNRHDCRLMTMCGMAGAFSAIFGTPLAATVFTIEV 174

Query: 174 LNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIA 233
           +N       +  L   L++A  G   +G       +  +    ++    +    ++  + 
Sbjct: 175 VN--VGSMQYAALLPCLVSALLGVWISGQLGVAPTAFTLGATAELNPITLAQVLVLGILL 232

Query: 234 IAAGMVAVWCLPRLHAMMHQM-KNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVA 292
               +V    L     +  +   NP L + +GG ++  L  + G        +     V 
Sbjct: 233 AGLSIVFCELLHITPKLYTKFLPNPYLRVAVGGLLIIALTKLLGT----TDYNGAGSAVI 288

Query: 293 NQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITV 352
             A           +K+    +   +G++GG I P  F G   G  +   +  +PA +  
Sbjct: 289 AAAMVGQALPWAFALKMLFTALTLGAGYKGGEIVPIFFTGATFGCAVAPLL-GLPAPLGA 347

Query: 353 SCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLA 399
           +  ++ +    T     S+ +   V      LPL  +V   +++L +
Sbjct: 348 ALGMVALFCGCTNSPLASICLGLEVFGGQC-LPLFALVCAVSYMLSS 393


>UniRef50_Q1DG09 Chloride transporter, chloride channel (ClC) family n=3
           Tax=Proteobacteria RepID=Q1DG09_MYXXD
          Length = 433

 Score =  112 bits (280), Expect = 3e-23,   Method: Composition-based stats.
 Identities = 84/375 (22%), Positives = 149/375 (39%), Gaps = 15/375 (4%)

Query: 41  LWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVI----RFSQGHAGPDPACEPLIGAPVP 96
           ++  L       ++   W++  L + G+ +G V     R  +G             A VP
Sbjct: 30  VFLYLLDEATHFREGHPWLVYALPVAGLVLGAVYGKWGRPIRGGNNLVLDTVHASDAQVP 89

Query: 97  PSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARLLPRVN-RMEWTILASAGT 155
               P ++V  +L    G S G E   + +  +LA  +  R     + R E      AG 
Sbjct: 90  VRMAPMVLVGTVLTHLFGGSAGREGTAVQMGGSLADLVARRFRVGPDTRRELLAAGIAGG 149

Query: 156 IGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHY 215
            G++FGTPVA A+   + +        ++ L   L+A+  G + T      H   P    
Sbjct: 150 FGSVFGTPVAGAVFGLEVV--VVGRMGYEALLPALVASVVGDMVTRGLGIHHTPYPAPGA 207

Query: 216 GQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKN--PVLVLGIGGFILGILGV 273
             + +  +    + A       +V V  + RL  ++ Q     P+ +   G  +L +  +
Sbjct: 208 LPLTVAVLAKWLVFAVAVAVVAVVFVELMHRLKKLLEQRVQVLPLRMALGGLAVLLLWLL 267

Query: 274 IGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGV 333
            G    L  G+  +Q+   + A   S +      KLA  VV  A+GF GG + P  F+G 
Sbjct: 268 AGTDDYLGLGVPGIQRAFEDPALPVSAF----AWKLAFTVVTLAAGFLGGEVTPLFFIGA 323

Query: 334 ALGLMLHEHVPAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLP 393
           +LG +L   +  +P  +  +  +  +         L+L + AV +    +LP + IV   
Sbjct: 324 SLGNVLARLL-GLPLDLGAAVGMAALFAAAANTP-LALSIMAVELLGANVLPHVAIVATV 381

Query: 394 AWLLLAGKPMMMVNR 408
           A+LL   + +    R
Sbjct: 382 AYLLTGQRGIYPSQR 396


>UniRef50_A8SIK8 Putative uncharacterized protein n=1 Tax=Parvimonas micra ATCC
           33270 RepID=A8SIK8_9FIRM
          Length = 510

 Score =  112 bits (279), Expect = 3e-23,   Method: Composition-based stats.
 Identities = 68/398 (17%), Positives = 145/398 (36%), Gaps = 18/398 (4%)

Query: 7   RTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLT 66
           +  L L    + +GIA+  +      I   ++ ++     G +     S  +I  ++ + 
Sbjct: 13  KEDLKLLFYGILVGIAAGGLSSFYRYIIHGIEGII-----GGIVNISRSHFYIYPIIFIA 67

Query: 67  GIAVGLVIRFSQG-----HAGPDPACEPLIGA---PVPPSALPGLIVALILGLAGGVSLG 118
            I +  ++   +           P  E  I     P P   L   I    L    G S+G
Sbjct: 68  LIFISFLVTKIKKMSRFCGGSGIPQVEAEIKGYINPNPVKVLLAKIFGGALTALAGFSVG 127

Query: 119 PEHPIMTVNIALAVAIGARLLPRVNRMEWTI-LASAGTIGALFGTPVAAALIFSQTLNGS 177
            E P + +       +  +L       ++ I   ++  + A F  PVA  L   + ++  
Sbjct: 128 REGPSIQIGAMSGKLVSRKLKKNKTVEKFLITCGASAGLAAAFNAPVAGILFAVEEVHRH 187

Query: 178 SEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAG 237
               L     A  + A    L + + +        +   ++ + +  +  + A +    G
Sbjct: 188 ISKKLLVVCMAATITA---DLVSKILYGTETVFNFSMAEKLPLVNYWTLILFAVVLSVLG 244

Query: 238 MVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFS 297
           ++ ++ +     +   +        I  F+L I+ +I  P  L  G   M+++     F 
Sbjct: 245 VLYIFLMEFFMKIQDGLNLKKEFKLIPYFLLPIVILIFTPNLLGGGGFLMKEL-QTVDFP 303

Query: 298 TSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAIL 357
                LL ++KL   ++  +SG  GG  FP + +G  +G +  + +  +     +   + 
Sbjct: 304 IYMLILLFIVKLLFSIICFSSGVPGGIFFPILVLGATVGTIFGKIIDPIYINSFIILGMA 363

Query: 358 GIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAW 395
           G +  + R    S+ +   +  N + L  L IV L  +
Sbjct: 364 GYLTAIVRAPLTSIILIFEMTGNLSYLLPLSIVCLITY 401


>UniRef50_A8UVV7 tRNA (Uracil-5-)-methyltransferase Gid n=3 Tax=Aquificaceae
           RepID=A8UVV7_9AQUI
          Length = 569

 Score =  112 bits (279), Expect = 3e-23,   Method: Composition-based stats.
 Identities = 63/414 (15%), Positives = 136/414 (32%), Gaps = 27/414 (6%)

Query: 19  IGIASSLILIVVMKIASVLQNLLWQRLPG-------------TLGIAQDSPLWIIGVLTL 65
           IG+ + L  ++ +     L + + + + G                   + P  +   + L
Sbjct: 12  IGVLTGLFAVLFVHALEFLTHYVLELVVGYLQPLPAGEGTREHFSSYPERPYLLPLTVAL 71

Query: 66  TGIAVGLVIRFSQ---GHAGPDPACEPLIGA-PVPPSALPGLIVALILGLAGGVSLGPEH 121
            G+  GL+  F        G D A         +   +    +V   + +  G + G E 
Sbjct: 72  GGLVSGLLAHFLSPESAGVGTDAAIRAYHNKDRLSIKSSVVKLVTSAITIGTGGTSGREG 131

Query: 122 PIMTVNIALAVAIGARLLPRVNRMEWTIL-ASAGTIGALFGTPVAAALIFSQTLNGSSEV 180
           PI  +   +   +G             +       I A+F  P+A A+I ++        
Sbjct: 132 PIALIGAGVGSTVGELFRLNSKERRTALAVGLGAGIAAIFKAPLAGAIISAEVFFRRDFE 191

Query: 181 PLWDRLFAPLMAAAAGALTTGLFFH--PHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGM 238
              + +    +A+       GLFF   P FS  I     ++   +L+ A +  +      
Sbjct: 192 --IEAMIPGFIASVTSYSIFGLFFGFQPIFSAEIPKLLNVQPFSLLAYAGLGFVCAIVVR 249

Query: 239 VAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFST 298
           V  +   ++     + + P  +    G  +  L     PV++  G   +Q ++  +    
Sbjct: 250 VFTFVFFKVKEEFDKPRLPTYLKPALGGFVAGLIGAFVPVAIGNGYGWLQLILDGKLNDL 309

Query: 299 SDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPA-----VPAAITVS 353
           +   L A+  +  +     SG  GG   P+V +G  +G      +       +       
Sbjct: 310 TFIVLGALAVMLGVSFTLGSGMSGGVFGPSVMIGGLVGAAYSLALNQHYSLSLHVPSFTI 369

Query: 354 CAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVN 407
             ++ +     +    +L + A +     LL    + +  ++ L   K +    
Sbjct: 370 VGMVSLFAGAAKAPLSTLILIAEMTGGYELLVPAMVSVFISYFLSGKKSIFPSQ 423


>UniRef50_A6P174 Putative uncharacterized protein n=1 Tax=Bacteroides capillosus
           ATCC 29799 RepID=A6P174_9BACE
          Length = 423

 Score =  111 bits (278), Expect = 4e-23,   Method: Composition-based stats.
 Identities = 68/401 (16%), Positives = 137/401 (34%), Gaps = 22/401 (5%)

Query: 14  LPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLV 73
           + A  IG+    +  +          L            +    WI+ +L   G  + L+
Sbjct: 23  IFACLIGLICGGVGTLFHFAIDAAAEL------------RGEYPWILWLLPAGGALIVLL 70

Query: 74  IRF---SQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIAL 130
            R+    +               P+     P +  A ++    G S G E   + +  ++
Sbjct: 71  YRWCGMEKDRGTNFVLVAVRENEPLRLRTAPLIFAATVITHLVGGSSGREGAALQLGGSI 130

Query: 131 AVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAP 189
           +  IG  + L   +    T+   +    ALFGTP+AAA+   + +  S  V  +  +   
Sbjct: 131 SSKIGRWMGLDDKDSRVITMCGMSAAFSALFGTPLAAAVFSMEVV--SVGVMYYAAIVPC 188

Query: 190 LMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHA 249
            +A+  G      F  P     +     + +   L    +  +     ++    +     
Sbjct: 189 TIASLVGVGVAASFGVPPTVYDLTGVPALSIVTALQCVGMGVLFALLSILFCRVMHAAPK 248

Query: 250 MMHQM-KNPVLVLGIGG-FILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVI 307
           + ++    PVL   +GG  ++ +  ++          +     +  QA          ++
Sbjct: 249 LYNKFIPRPVLRAAVGGALVIALTYLVWLWNPGTYDYNGAGAGLIAQAIGGQARPEAFLL 308

Query: 308 KLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLVVTRDG 367
           K+    V   +GF+GG I P  F G   G +    +  +PA    +  +  +   VT   
Sbjct: 309 KILFTAVTLGAGFKGGEIVPVFFTGATFGCVAAPFL-GLPATFGAALGMTAVFCGVTNCP 367

Query: 368 WLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNR 408
             SLF+A  +      LPL  +    A++L     +    +
Sbjct: 368 MTSLFLAYELFGGQG-LPLFALSCAVAYMLSGYYGLYSEQK 407


>UniRef50_C7PDX9 Chloride channel core n=3 Tax=Bacteria RepID=C7PDX9_CHIPD
          Length = 453

 Score =  111 bits (278), Expect = 4e-23,   Method: Composition-based stats.
 Identities = 71/386 (18%), Positives = 135/386 (34%), Gaps = 22/386 (5%)

Query: 41  LWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRFSQGHA-GPDPACEPLIGAP---VP 96
           L+  L   + + +    W++ +L + GI +  + +   G +   +      I  P   VP
Sbjct: 62  LFLWLLEEVTLLRWQHGWLLFLLPIAGILIHFLYKKLGGTSEAGNNLIMDEIHEPGGGVP 121

Query: 97  PSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGT 155
               P +I   I+    G S G E   + +  ++A  +G    L   +     +   A  
Sbjct: 122 ARMAPLVIATTIITHLFGGSAGREGTAVQIGGSMAHMLGRWFRLSAADVKIILMTGIAAG 181

Query: 156 IGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPI--- 212
            GA+FGTP+  A+   + L  +  +  +D L   L+AA    +    +   H    I   
Sbjct: 182 FGAVFGTPLTGAVFALEVL--AIGLMRYDALIPCLIAAVFADIVCSAWGIHHTHYQILFE 239

Query: 213 -----AHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMM-HQMKNPVLVLGIGGF 266
                 H+   ++  ++           A  +   C+  + +     +K P+L+  IGG 
Sbjct: 240 SNHISFHFVHFDLLLLIKVIACGIAFGLASFLFATCMRNIKSYAKAWIKIPLLIPAIGGL 299

Query: 267 ILGI---LGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLA-VIKLAALVVAAASGFRG 322
           I+     L      + L     +   +    AF+T +      + KL    +    GF+G
Sbjct: 300 IVIGGCYLLGTRDYIGLGVTTPDPNGVSIVNAFTTKEISSWGWLWKLLLTAITLGMGFKG 359

Query: 323 GRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTT 382
           G + P  F+G  LG  L   +   P  +      + +    T        M   +   TT
Sbjct: 360 GEVTPLFFIGATLGHTLAVLM-GAPVDLFAGLGFIAVFAGATNTPIACTLMGVELF-GTT 417

Query: 383 LLPLLCIVMLPAWLLLAGKPMMMVNR 408
            +    +    A+       +    R
Sbjct: 418 HVLYFAVACFTAYYFSGHAGIYSAQR 443


>UniRef50_B9L7R0 Voltage-gated chloride channel n=2 Tax=Nautiliaceae
           RepID=B9L7R0_NAUPA
          Length = 573

 Score =  111 bits (277), Expect = 5e-23,   Method: Composition-based stats.
 Identities = 77/405 (19%), Positives = 142/405 (35%), Gaps = 23/405 (5%)

Query: 12  LSLPAVAIGIASSLILIVVMKIASVLQ----NLLWQRLPGTLGIAQDSP--------LWI 59
           L L    IGI  S+   + + +   +       L   LP       +S         L +
Sbjct: 14  LILDTFIIGIIGSVCAQIFIVLLHFISKFSLEYLVGYLPQDTLKLLESYQHSGEFNNLML 73

Query: 60  IGVLTLTGIAVG-LVIRFSQGHAGPDPACEPLI----GAPVPPSALPGLIVALILGLAGG 114
           I V+   G+  G LV  F+    G             G  +    +P  I+A  + +  G
Sbjct: 74  IAVIVSGGLISGFLVYTFAPEAEGHGTDTVIRAFHRQGGYIRWIVVPVKILASAITIGTG 133

Query: 115 VSLGPEHPIMTVNIALAVAIGARLLPRVNRME-WTILASAGTIGALFGTPVAAALIFSQT 173
            S G E P    +  +             R + + ++  A  + A+F  P+  ++   + 
Sbjct: 134 GSAGREGPTALFSAGVGSWYSDLRKVGWKRRQIYVLIGMASGLSAVFKAPLGTSIFAIEV 193

Query: 174 LNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIA 233
           L   +E    + ++       A  + TG  F       +      ++   L    +  ++
Sbjct: 194 LYADNEFETRELIYLLFGPLIA-YMITGFLFGWEPIFYVPEINITDLKTYLEIVFLGIMS 252

Query: 234 IAAGMVAVWCLPRLHAMMHQMK-NPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVA 292
               +V       +      +   P     IG F++GI+  I  P  L  G   +Q+ + 
Sbjct: 253 GMIALVLPNIFYGIRDFFRSLPVKPHFKPAIGAFVVGIIA-IYFPEVLGGGYGFIQESIN 311

Query: 293 NQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITV 352
                    FL+ + K+ A      SG  GG   P++F+G  LG  L   + A P A  V
Sbjct: 312 GNMIGMFVIFLM-IAKIFAFSFTVGSGGSGGVFAPSLFIGAMLGAFLGSSLHA-PVAAFV 369

Query: 353 SCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLL 397
             A+  +     R    ++ M   +    +LL    + +L A+++
Sbjct: 370 VIAMAAVFGAAARTPLATIVMVVEMTGGYSLLAPTTLGVLSAYIV 414


>UniRef50_B7FTG7 Predicted protein n=2 Tax=cellular organisms RepID=B7FTG7_PHATR
          Length = 588

 Score =  111 bits (277), Expect = 5e-23,   Method: Composition-based stats.
 Identities = 80/424 (18%), Positives = 143/424 (33%), Gaps = 59/424 (13%)

Query: 16  AVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVG---L 72
           A  +GI +   + +     + +++L ++++       Q +P+ ++ V  + G AVG   L
Sbjct: 119 AGIVGIFTGFSVALFKLSINAVKSLCYRQI-----FFQTNPVLMVTVPAMGGAAVGVLML 173

Query: 73  VIRFSQGHAGPDPACEPLIGAPVPPSA--------LPGLIVALILGLAGGVSLGPEHPIM 124
           +  F  G  G     +      V                  A  + L  G SLGPE P +
Sbjct: 174 LGDFPPGLRGTVIEVDKESQGTVQKLRDRVQTQFRFLRKSAAATVTLGTGCSLGPEGPCV 233

Query: 125 TVNIALAVAIGARLLPRVNRMEW-----TILASAGTIGALFGTPVAAALIFSQ------- 172
            + + +A +          R            +A  + A F  P+A      +       
Sbjct: 234 EIGMDVARSCMDISRRTAERQRLWNRMLLSCGAAAGVSAGFNAPIAGTFFALEIMHRMFS 293

Query: 173 ----TLNGSSEVPLWDR------LFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTD 222
                 N   +            +   L+A+   AL        H  L +     ++   
Sbjct: 294 SIDGEENADKDASAGLSSLNTATIAPVLIASVMSALCARTLLGDHLVLALGGSYSLK-KP 352

Query: 223 ILSGAIVAAIAIAAGMVAVWCLPRL---------------HAMMHQMKNPVLVLGIGGFI 267
           ++   +   + + +G V+                        M  +  +P     IGG +
Sbjct: 353 LIELPLYMVLGLVSGTVSFAFSRAANLSQAVFVGDYGSDRFRMGVRSLSPAFKPVIGGIL 412

Query: 268 LGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFP 327
            G++G I  P  LF G D +  ++AN +  T     L   K++   ++A SG  GG   P
Sbjct: 413 CGLVG-IKFPQILFFGYDCLNPLLANNSLPTPLLLSLLAAKISITAISAGSGLVGGTFAP 471

Query: 328 AVFVGVALGLMLHEHVPAV----PAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTL 383
           ++F+G   G   H  V ++          S  +L  V      G  S+  A    P T  
Sbjct: 472 SLFLGAVTGAAFHNIVSSILYCGLGLSAASGPLLADVPAYAMVGAGSVLAALFRAPLTAC 531

Query: 384 LPLL 387
           L L 
Sbjct: 532 LLLF 535


>UniRef50_A8TQW2 Cl-channel, voltage-gated family protein n=1 Tax=alpha
           proteobacterium BAL199 RepID=A8TQW2_9PROT
          Length = 591

 Score =  111 bits (277), Expect = 6e-23,   Method: Composition-based stats.
 Identities = 70/393 (17%), Positives = 136/393 (34%), Gaps = 33/393 (8%)

Query: 22  ASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRFSQGHA 81
           A S +  + +     L            G  +     I       G+ VGL+  +     
Sbjct: 45  AISAVQWLFLGFHHELV---------ASGARESGWWRIALAPAAGGLLVGLITYWLM--P 93

Query: 82  GPDPACEPLI-------GAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAI 134
           G  P     +          +      G  V  IL +  G S+G E P + +  ALA  +
Sbjct: 94  GRRPQGVANVIEASALRAGRMSFRQGIGAAVISILSIGSGASVGREGPAVHLGAALASFV 153

Query: 135 GARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAA 193
           G  L L R           A  + A F  P+A      + + G   +         ++A+
Sbjct: 154 GRPLHLTRSQSRTLLGCGVASAVAASFNAPIAGVFFALEVVIGHYAL---SAFAPIVIAS 210

Query: 194 AAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQ 253
             G + + ++F    +  +A+Y  +      + A++     AA +  +     +      
Sbjct: 211 VCGTIVSRMWFGDFPAFRLANYEIVSFLQFPAFALLGIACAAAAIALMRLTAMVERTAET 270

Query: 254 MKNPV-LVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAAL 312
           +  P  L     G I+G++  +  P  L  G +     +  Q +       LAV+K+   
Sbjct: 271 LPGPRWLHPAFAGLIVGVVA-LWYPEILGVGYEATDNALKEQ-YGFQLLATLAVLKILMT 328

Query: 313 VVAAASGFRGGRIFPAVFVGVALGLMLHE-------HVPAVPAAITVSCAILGIVLVVTR 365
            +   +GF GG   P++F+G  +G            H+ +   A T+   +  +   V  
Sbjct: 329 ALCLGAGFGGGVFSPSLFIGAMVGGSFGLVASHPFPHLSSGHGAYTMIG-MGAVAGAVLG 387

Query: 366 DGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL 398
               ++ +   +  +  L   + + ++ A LL 
Sbjct: 388 APISTILIIFELTSDYRLTIGVMVAVVIASLLT 420


>UniRef50_A8ZW16 Chloride channel core n=1 Tax=Desulfococcus oleovorans Hxd3
           RepID=A8ZW16_DESOH
          Length = 603

 Score =  111 bits (277), Expect = 6e-23,   Method: Composition-based stats.
 Identities = 66/406 (16%), Positives = 143/406 (35%), Gaps = 24/406 (5%)

Query: 9   MLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGI 68
            L+  L AV +G  + +  I    +      LL+   P    +     L  I ++ + G 
Sbjct: 32  YLIQILFAVLVGSLAGIGAIFFHYVVEE-MRLLFS--PDRFDLLWPGILHPIMLVPVAGA 88

Query: 69  AVGLV----IRFSQGHAGPDPACEPLI--GAPVPPSALPGLIVALILGLAGGVSLGPEHP 122
            V  V       + G  G +   + LI     +P       + A I+ +  G  LGPE P
Sbjct: 89  LVLAVATVRFPKTAGERGVESVIKALIIKNGVIPLKTTLFHMFAAIMTIGTGAPLGPEGP 148

Query: 123 IMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVP 181
              +   +  A+     L R N   +T   +   I A+F  P+A      + +  +    
Sbjct: 149 AAKIGSGMGSALSQWFGLNRENIKIYTAAGAGAAISAVFNAPIAGVFFAIEVVLLNDLKN 208

Query: 182 LWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAV 241
             + L   ++A+    + +           I HY  +    +    ++A    A  +   
Sbjct: 209 --EALSFLIIASIVADILSRAVLGNDVIFTIPHYAPIHFAHLPWFLLLAVCCGAMSLFYF 266

Query: 242 WCLPRLHAMMHQMK---NPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFST 298
                +  +  ++    NP + L     + G++ ++        G   M  ++ N     
Sbjct: 267 GTSKTVKHLFDRLPGNQNPFVRLLPVAVVFGLV-LLHFNELFGIGYTTMNAVLNNAFAPV 325

Query: 299 SDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHV------PAVPAAITV 352
              +L+ + ++  L +   +G  GG   PA+ +GV  G +    V         P    +
Sbjct: 326 VVLWLM-LFRIVFLALFLRAGAFGGTFAPALGIGVMFGFLFATTVNTLLGTSLDPVVFGL 384

Query: 353 SCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL 398
              + G++  +      S+ +   +  +  ++  L    + +++++
Sbjct: 385 VG-MGGVLAGINSIPLTSILLVFELTRDFRIVLPLMAASIISYIVV 429


>UniRef50_C0YIY4 Chloride carrier/channel (ClC) family transporter n=3
           Tax=Bacteroidetes RepID=C0YIY4_9FLAO
          Length = 435

 Score =  111 bits (276), Expect = 8e-23,   Method: Composition-based stats.
 Identities = 72/376 (19%), Positives = 131/376 (34%), Gaps = 24/376 (6%)

Query: 6   ARTMLLLSLP-AVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLT 64
           A   +L  L  ++ IG          ++    + N             +++ LW+I  L 
Sbjct: 25  ALPYILKWLFISMIIGALVGTASAGFLQSLEWVTNF------------RENHLWLIAFLP 72

Query: 65  LTGIAVGLVIR-FSQGHAGPDPACEPLIGAP---VPPSALPGLIVALILGLAGGVSLGPE 120
           + G  +GL+   F +     +      I  P   +P    P + +  I     G S G E
Sbjct: 73  VAGFLIGLLYYYFGKDVEAGNNLLIDTIHEPKGIIPFKMAPFVYLGTIATHFFGGSAGRE 132

Query: 121 HPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSE 179
              + +  A+A  +     L R +R    I A A   G++FGTP+A A+   +       
Sbjct: 133 GTALQMAGAIADQLTKPFKLDRNDRKVLIISAIAAGFGSVFGTPLAGAVFGLEVFLIGRI 192

Query: 180 VPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMV 239
              ++ +F    +A    L T L+   H    I    ++E   IL   +           
Sbjct: 193 --RYNAIFPAFASAVLADLVTNLWKVKHTHYHIDFVPKLEFLPILYSILAGIAFGICAAA 250

Query: 240 AVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTS 299
               +  + +          +  + G I+  L V     + + GL     M+        
Sbjct: 251 FSKIIHWMGSFFKSKVKYPPLRPVAGGIIIALAVFAMGTTRYIGLG--IPMIMESFEKQL 308

Query: 300 DYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGI 359
             +  A+ K+   +V  ++GF+GG + P  F+G  LG  L   +P  P  +      + +
Sbjct: 309 PLYDFAL-KMIFTIVTLSAGFKGGEVTPLFFIGATLGSALSLFIPL-PFGLLAGMGFVAV 366

Query: 360 VLVVTRDGWLSLFMAA 375
               T      + M  
Sbjct: 367 FAGATNTPLACMLMGI 382


>UniRef50_C4Z1M2 Chloride channel protein, CIC family n=1 Tax=Eubacterium eligens
           ATCC 27750 RepID=C4Z1M2_EUBE2
          Length = 425

 Score =  110 bits (275), Expect = 1e-22,   Method: Composition-based stats.
 Identities = 69/401 (17%), Positives = 143/401 (35%), Gaps = 11/401 (2%)

Query: 10  LLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIA 69
           L L++  +   +  S +    +     + +L+   + G+L +     L+ + V  +  + 
Sbjct: 18  LKLAVITLFKWLFCSFVCGCFIGSVGAVFHLMLGYV-GSLRVEYPFLLFGLPVAGIIIVF 76

Query: 70  VGLVIRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIA 129
           +  ++  +                 VP    P +I++ +L    G S G E   + V  A
Sbjct: 77  MYNIVHEAGNRGTNLVITAIQSNDEVPGRVAPLIIISTLLTHLCGGSAGREGAALQVGGA 136

Query: 130 LAVAIGARLLPRV-NRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFA 188
           L             +     +   +    ALFGTP+AAA+   + +  S  V  +  L  
Sbjct: 137 LGNTFAKLFKFDEKDTRIMIMCGMSACFSALFGTPIAAAVFSMEVI--SVGVMYYAALVP 194

Query: 189 PLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLH 248
            ++AA                  +         +     I++ +     ++    L    
Sbjct: 195 CVLAAFVAQGIASALGLESTHFVVDEIASFSFINGSKFIIMSVLFALVSILLCVVLHGTS 254

Query: 249 AMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIK 308
            +     N   +  I   +L I        + + G       +  ++F TS  + + ++K
Sbjct: 255 KLYINYINNPYIRIIIAGVLVISMRYIFGTTDYLG---AGSDIIAKSFVTSCAWYVFLLK 311

Query: 309 LAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLVVTRDGW 368
           +    V    GF+GG I P +FVG  LG  L      +P  +  +C ++ +   VT    
Sbjct: 312 MLFTAVTLGGGFKGGEIVPTLFVGATLGSFLAPIF-GLPVGLCAACGMVSVFCGVTNCPL 370

Query: 369 LSLFMAAVVVPNTTL-LPLLCIVMLPAWLLLAGKPMMMVNR 408
            S  ++  +   +T+   +LCI +  ++LL     +    +
Sbjct: 371 TSFILSIEMFGASTMKFTILCIAL--SYLLSGYYSLYNSQK 409


>UniRef50_Q31NT2 Chloride channel-like n=2 Tax=Synechococcus elongatus
           RepID=Q31NT2_SYNE7
          Length = 615

 Score =  109 bits (273), Expect = 1e-22,   Method: Composition-based stats.
 Identities = 89/397 (22%), Positives = 155/397 (39%), Gaps = 30/397 (7%)

Query: 24  SLILIVVMKIASVLQNLLWQRLPGTL---GIAQDSPLWIIGVLTLTGIAVGLVIRFSQGH 80
              ++    +   L   ++  L  TL   G  Q   L  +    + G  + +  RF    
Sbjct: 45  GAAIVGFHLLYESLHQGVFSWLSSTLSAWGGHQTLALIPLLGGLVMGGLILIWPRFGPSM 104

Query: 81  AGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARL-L 139
            G         G    P   P  + A  L LA G SLGPE P +     L +AI     +
Sbjct: 105 TGLIGLARGTGGDE--PLRTPQKLFAASLSLASGASLGPEGPSVESGGNLGLAIARWAKM 162

Query: 140 PRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALT 199
            R  ++      +A  I A F  P+A      + + G+S       + A L+AA   AL 
Sbjct: 163 SRERQLLLIGAGAAAGIAAGFNAPIAGVFFAFEVVLGTSFA--GAAVSAVLIAAVLSALV 220

Query: 200 TGLFFHPHFSLPIAHY---GQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHA------- 249
             +      +  +  Y     +E+   L   ++A++  ++ M  V  L +          
Sbjct: 221 AQVGLGAQPAFSLPDYVVRSPLELPLYLGLGVLASLVSSSYMALVQVLQQAFRGETAIGA 280

Query: 250 MMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKL 309
           ++ ++    L   + G I+G++  +  P  L  G + ++ +++  + +     LL + KL
Sbjct: 281 VLGRIPRS-LRPALAGLIVGLVA-LQFPQVLGVGYETIEGLLSGMSLTPLTLVLLLIGKL 338

Query: 310 AALVVAAASGFRGGRIFPAVFVGVAL----GLMLHEHVPA--VPAAITVSCAILGIVLVV 363
               +  ASGF GG   PA+F+G  L    G +L    P   +P A   + A++G+  V+
Sbjct: 339 GLTALCLASGFVGGGFAPAMFLGAVLGSFYGWVLTAFFPTSWIPIASPPAYAMVGMAAVL 398

Query: 364 TRDGWLSLFMAAVVVPNTT----LLPLLCIVMLPAWL 396
                  L    ++   T     +LPL+    L AWL
Sbjct: 399 AGSVRAPLTAILLLFELTRDYRIVLPLMAAAGLSAWL 435


>UniRef50_C1TRX3 Chloride channel protein EriC n=3 Tax=Synergistaceae
           RepID=C1TRX3_9BACT
          Length = 480

 Score =  109 bits (273), Expect = 1e-22,   Method: Composition-based stats.
 Identities = 58/398 (14%), Positives = 131/398 (32%), Gaps = 19/398 (4%)

Query: 14  LPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLV 73
           L AV  G     +    +       +        T  +      +++ +  +    +   
Sbjct: 29  LLAVLAGAVVGSVTTFFVNSLEWAISW-------TAKLPPTFLWYMLPLGIVASTLIIKC 81

Query: 74  IRFSQGHAGPDPACEP--LIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALA 131
                   G +   E        +    +P  ++  ++ +A G S G E P   +   L 
Sbjct: 82  FAPDARGHGTEKVIEAIHEHSGKISVKVIPIKLITTVITVAAGGSAGKEGPAAQIGAGLT 141

Query: 132 VAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPL 190
            ++ + L    ++R +  I   +    A+FGTPVA A+   + L        +D LF   
Sbjct: 142 SSLASLLRFSDLDRKKLVICGISAGFAAVFGTPVAGAIFGLEVL--YIGQVFYDVLFPSF 199

Query: 191 MAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAM 250
           ++     L        +   P+     M     L   +  A       + +  +     +
Sbjct: 200 ISGVVSHLVATSLGMSYGYYPLCDIPAMSGGIFLWMVVAGAFFGFVSFLHIEIMSFFERV 259

Query: 251 MHQMKNPVLVLGIGGFILGI-LGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKL 309
             +++  ++V  I G +L + L    G      G D + + +  +      +      K 
Sbjct: 260 FSKVRGGLVVKAILGAVLMLFLAQTVGGEYFGLGTDVIDKALHGEKLPGLAFLW----KS 315

Query: 310 AALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLVVTRDGWL 369
               +  + G  GG + P  F+G   G+        +  A+      + ++        +
Sbjct: 316 LFTAITLSCGGSGGVVTPIFFIGATAGVTFASFF-GLNGALFGPIGFVAVLAGCANAP-I 373

Query: 370 SLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVN 407
           S  + AV +  +++     I  + ++LL+  + +    
Sbjct: 374 SASIMAVELFGSSVASFAAIACITSFLLVGHRSVYPSQ 411


>UniRef50_C5NXG2 H(+)/Cl(-) exchange transporter ClcA n=1 Tax=Gemella haemolysans
           ATCC 10379 RepID=C5NXG2_9BACL
          Length = 507

 Score =  109 bits (273), Expect = 1e-22,   Method: Composition-based stats.
 Identities = 61/387 (15%), Positives = 134/387 (34%), Gaps = 14/387 (3%)

Query: 17  VAIGIASSLILIVV---MKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLV 73
           + +G+ + ++       +  +  L +   + +             +I +   +G    L+
Sbjct: 25  ILVGLFAGIVGASYRLLIGYSEKLVHYTAEFIKNGFIYKIFLLGALILLALFSGF---LL 81

Query: 74  IRFSQGHAGPDPACEPLIGAPVPPSALPGLIV---ALILGLAGGVSLGPEHPIMTVNIAL 130
            R         P     I   + P+ L  LI      +    GG+SLG E P + +    
Sbjct: 82  KREPMASGSGIPQVSAEITGRLNPNPLRILIYKITGGLTASLGGLSLGREGPSIQLGAMS 141

Query: 131 AVAIGARLLPRVNRMEWTI-LASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAP 189
              +   L   + + ++ I   ++  +   FG P+A  L   + ++          +   
Sbjct: 142 GKLVSRILKKDIIKEKYFITCGASAGLSIAFGAPLAGVLFSIEEVHKQIT---KKIIICC 198

Query: 190 LMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHA 249
             AA    +     F             +E++     A++  +    G      +  L  
Sbjct: 199 FSAAVVANIVGQYIFGLTAIFKFPDIPYVEVSIYPWVALLGILLGIFGTFYNITIKILFR 258

Query: 250 MMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKL 309
           +   +K  ++      F++  +  I  P+ L  G + ++ ++ N+ FS      L  IK 
Sbjct: 259 IYEFLKLNIVFRPQIAFLISFVLFIFYPIVLGSGHNLVEFLIENK-FSFMFLLTLYFIKT 317

Query: 310 AALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLVVTRDGWL 369
              +++  SG  GG   P +  G  LG +      A   A+ V  ++ G +  + R    
Sbjct: 318 LFSLISFTSGVAGGIFLPILIQGAILGTLFSNFFDAKYTALFVILSMSGYLTAIVRSPIT 377

Query: 370 SLFMAAVVVPNTTLLPLLCIVMLPAWL 396
           S+ +   +         + +  L A++
Sbjct: 378 SIILLFEMTQKLNYFLPIALCCLFAYM 404


>UniRef50_B2IWH4 Cl-channel, voltage-gated family protein n=2 Tax=Nostocaceae
           RepID=B2IWH4_NOSP7
          Length = 634

 Score =  109 bits (273), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 84/417 (20%), Positives = 155/417 (37%), Gaps = 22/417 (5%)

Query: 16  AVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIR 75
           A+ IG  + + ++    +  ++  L+ + L G +G+       +  V TL G+ VGL+  
Sbjct: 44  AMLIGGGTGMGVVTFHYLIQLIHQLMLENLMGQIGV--WGAWTLACVPTLGGLIVGLMRW 101

Query: 76  FSQGHAGPDPACEPLI-GAPVPPSALPGL-IVALILGLAGGVSLGPEHPIMTVNIALAVA 133
            +Q       +      G  +     P   ++A  + L  G SLGPE P + +     + 
Sbjct: 102 RTQDFGPGLSSLIAASQGTEIKRPLRPVTKMLAASVSLGSGASLGPEGPSVEIGANFGML 161

Query: 134 IGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMA 192
               L + +  +       +A  + A F  P+A      + + G++           L A
Sbjct: 162 FSVILNVSQERQRLLLGAGAAAGLAAGFNAPIAGVFFALEVVMGATSFATSAVSVVLLAA 221

Query: 193 AAAGALT-TGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVW------CLP 245
             A  +   GL   P F LP           +  G  + A  ++     +          
Sbjct: 222 VVAALIAQIGLGAQPAFDLPAYQVRSPLELPLYLGLGLGASLVSLAYTQLIRLAKACFAG 281

Query: 246 RLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLA 305
           ++       + P  +  I G ++     +  P  L  G + ++ M+ +  F  S   +L 
Sbjct: 282 KVRGFAFLGRIPEPIHPIIGGVIIGAVALYFPQILGVGYETVEAMLQDVEFPLSLLVVLL 341

Query: 306 VIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCA---------I 356
           V+KL    ++A SGF GG   PA+F+G + G    + +      I    A         +
Sbjct: 342 VVKLLMTAISAGSGFIGGLFAPAMFLGASFGSAYAKLLAVAFPTICDQMAAPPAYAMVGM 401

Query: 357 LGIVLVVTRDGWLSLFMAAVVVPNTTL-LPLLCIVMLPAWLLLAGKPMMMVNRPKQQ 412
             ++    R    ++ M   +  +  + LPL+  V L  WL+   KP    N   QQ
Sbjct: 402 AAVLAASVRAPLTAILMLFELTRDYRIVLPLMAAVGLSVWLVERIKPTFNSNSNLQQ 458


>UniRef50_C8X3C6 Cl-channel voltage-gated family protein n=1 Tax=Desulfohalobium
           retbaense DSM 5692 RepID=C8X3C6_DESRD
          Length = 597

 Score =  109 bits (273), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 81/390 (20%), Positives = 152/390 (38%), Gaps = 23/390 (5%)

Query: 15  PAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVL-TLTGIAVGLV 73
            AVAIG  +++  ++        Q LLW      +   Q +P W++ ++ TL G+ VG V
Sbjct: 31  FAVAIGFLAAVGALLFRSCIEGFQFLLWPGGASLVEQVQAAPWWMVLLVPTLAGLVVGPV 90

Query: 74  IRFS--QGHAGPDPACEPLIGAPVPPSALPGLIVALILG---LAGGVSLGPEHPIMTVNI 128
           I F   +      P     +             +  ++    LA G S+G E PI+ +  
Sbjct: 91  IAFFVPEARGPGVPEVILSVTTRQSTIRHRVTFLKGLITSLLLAAGASVGREGPIVQIGS 150

Query: 129 ALAVAIGARLLPRVNRMEWTILASAGTIGAL-FGTPVAAALIFSQTLNGSSEVPLWDRLF 187
           ++  ++      R       +   A    A  F  P+A +L   + +  + EV     + 
Sbjct: 151 SVGSSLAQFFGLRPELRRLCLACGAAAGIAATFNAPIAGSLFALEIILMNIEVSY---IS 207

Query: 188 APLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRL 247
             ++AA  G++ + +F+    +  +  +     +++L   ++  +A    +V V  +   
Sbjct: 208 HIVIAAITGSVLSRIFWGDFPAFRVVPFELGSYSELLGYLVLGILAGLVSIVFVRSIFAT 267

Query: 248 HAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVI 307
             +  +++ P  +    G +L     +  P  +  G + +   +AN +       +L   
Sbjct: 268 ENIFQRLRLPQWLSPAIGGLLLGCLALSLPQVMGVGYETVNDALAN-SLPLQMALVLLAA 326

Query: 308 KLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLVVTRDG 367
           KLAA  +   SG  GG   P++F+G ALG ++      V  A  +  A            
Sbjct: 327 KLAATAICIGSGMSGGIFAPSLFLGAALGTVVGLGATVVWPAHDLHPAFFA--------- 377

Query: 368 WLSLFMAAVVVPNTTLLPLLCIVMLPAWLL 397
              L     VV  TTL P+  IV +    L
Sbjct: 378 ---LAGMGAVVSGTTLAPITAIVTIFELTL 404


>UniRef50_C6W519 Chloride channel core n=1 Tax=Dyadobacter fermentans DSM 18053
           RepID=C6W519_DYAFD
          Length = 617

 Score =  109 bits (271), Expect = 3e-22,   Method: Composition-based stats.
 Identities = 64/411 (15%), Positives = 130/411 (31%), Gaps = 34/411 (8%)

Query: 12  LSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWII-GVLTLTGIAV 70
           L L  + +GI   L  +    +   L + +   +   +   +    +I+   L +    V
Sbjct: 49  LILSGILVGITCGLAGV----VLKSLVHYIHHVITYRVHFERQVFFYILFPFLGIVLTTV 104

Query: 71  GLVIRFSQGHAGPDPACEPLIGAPVPPSALPGL---IVALILGLAGGVSLGPEHPIMTVN 127
            +   F         A    I       +   +   IV   + +  G S G E PI    
Sbjct: 105 VVQFFFKGQDRKGIAAVLYEIAQNSSIVSSVKMYSQIVQSAITVGLGGSAGLESPIAVTG 164

Query: 128 IALAVAIGARLLPRVNRMEWTILASA-GTIGALFGTPVAAALIFSQTLNGSSEVPLWDRL 186
            A+                  + A A   I + F  P+A  +   + L       ++   
Sbjct: 165 AAIGSNFAQTYKLDYRERTLLLAAGATAGIASAFNAPIAGMMFAFEILLTGV---VFFDF 221

Query: 187 FAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPR 246
           F  ++AA  G+LT+ +          +     +  +I    ++  +    G   V     
Sbjct: 222 FPLVVAAVCGSLTSKVLLKESVLFQFSSRAPFDYHNIPFYLLLGILCGLYGRYYVLIGKY 281

Query: 247 LHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFS--------- 297
           +    H +K   +     G  +  +  +  P    +G D ++ +   Q            
Sbjct: 282 VDQWFHNLKMGRIQKAAIGGAVLSVLCVLYPPLFGEGYDTIKAITNGQIQEVIANSFFRF 341

Query: 298 --------TSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEH-----VP 344
                        ++ ++K  +  +   SG  GG   P++F G  +G           + 
Sbjct: 342 IGYHEWVVIVFVAVICLLKAFSASITIFSGGNGGNFAPSLFAGGLVGYAFALVCTQLGIE 401

Query: 345 AVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAW 395
            VP +  V   + G++  V      ++F+ A       L   L IV + ++
Sbjct: 402 HVPESNLVIVGMAGVMSGVLYAPLTAIFLIAESTYGYDLFIPLMIVSVISF 452


>UniRef50_B8FBB1 Chloride channel core n=1 Tax=Desulfatibacillum alkenivorans AK-01
           RepID=B8FBB1_DESAA
          Length = 573

 Score =  109 bits (271), Expect = 3e-22,   Method: Composition-based stats.
 Identities = 65/391 (16%), Positives = 123/391 (31%), Gaps = 28/391 (7%)

Query: 12  LSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVG 71
           L L  V +G  S +    +      L  L                 W+  +  +      
Sbjct: 23  LLLAGVLVGCCSGVAAAGLSFAIEHLWELCAH---------AKHYWWVFVLPGVGAALSS 73

Query: 72  L----VIRFSQGHA-GPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTV 126
           L    ++R   GH            G  +   +    +V+  L +  G S GPE P++  
Sbjct: 74  LFLNKIVREGAGHGVPEIIYAVSRRGGLLRFRSSFSRLVSSCLTIGSGGSAGPEAPVVMS 133

Query: 127 NIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDR 185
             A+   I  RL  P  +R+      +A  I ++F  P+A  +   + + G         
Sbjct: 134 GSAIGSNIAQRLGFPARHRITLVGCGAAAAIASIFNAPIAGIVFTLEVVLGEWTA---VN 190

Query: 186 LFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLP 245
           +    +A+ AG     L           H+      DI +   +A       +     + 
Sbjct: 191 VIPIGVASVAGTQVGRLLMGNSIRFSHTHFSPGTW-DIAAAFGLALATALISVALSRMIR 249

Query: 246 RLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLA 305
               +  ++    +     G     L  +  P  L +G +++  ++  Q           
Sbjct: 250 SSGKVWGKLPASKMSRAFVGGACVGLVGLFFPQVLGEGYNQIYSLIHGQYSPGLMLLCAI 309

Query: 306 V-IKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHV-------PAVPAAITVSCAIL 357
           + +K+        SG  GG   P + VG   G+     +       P  P        + 
Sbjct: 310 LGLKMLVTATTLGSGGSGGIFAPGLVVGSFTGVAYFRLLSLMFDVTPLAPEGCYALLGMA 369

Query: 358 GIVLVVTRDGWLSLFMAAVVVPN-TTLLPLL 387
           GI+  + +     LF+   +      +LPL+
Sbjct: 370 GIMGGMLQAPLTGLFLVVDITSGYEVILPLI 400


>UniRef50_A4BAH0 Chloride channel protein EriC n=1 Tax=Reinekea blandensis MED297
           RepID=A4BAH0_9GAMM
          Length = 572

 Score =  109 bits (271), Expect = 3e-22,   Method: Composition-based stats.
 Identities = 72/390 (18%), Positives = 137/390 (35%), Gaps = 17/390 (4%)

Query: 11  LLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAV 70
           LLS+  VA G+A+SL+++  M    +  + L  +     G    SP   + +     + +
Sbjct: 21  LLSVLGVATGLATSLVIVGFMLAIDLTTSAL--QAGQETGFEGFSPWVRLLLPLTGSVLL 78

Query: 71  GLVIRFSQGH-----AGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMT 125
            L+ R +                      +P         A ++ L GG SLG E P + 
Sbjct: 79  ILLYRLTPTERQDVGITHVIDRLQRGRGRLPLGNTFFQFFAALITLTGGFSLGKEGPAVH 138

Query: 126 VNIALAVAIGARLLPR-VNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWD 184
           V   +A  +G  +          T   +A  I A FGTP+A  L   + +     +    
Sbjct: 139 VGSGIASRLGLAVHRSPSQLRLLTGCGTAAAISAAFGTPLAGVLFAMEVVLMEYSLT--- 195

Query: 185 RLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCL 244
                + AA    ++T      H       +        +   ++     A   +    +
Sbjct: 196 GFIPIIAAAVTATVSTQFIMGEHPVFLQVSFDSSADLPFVWLVVLGVATGAIAALMHKFI 255

Query: 245 PRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLL 304
            ++  +   + N        G I G++G+   P  L  G   M  + A +         +
Sbjct: 256 KQI--LALNIVNREWRFLTAGLITGLIGM-ALPQILGLGYGTMNSIAAGE-LGFMLLLAV 311

Query: 305 AVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAV--PAAITVSCAILGIVLV 362
            V K+AA  VA   G   G + P++ +G+A G ++    P     A   +      +  +
Sbjct: 312 LVGKIAATSVAVGFGIPAGIVAPSLVIGMATGALIGGLAPDQSNNAVFALVGMAGMMSAL 371

Query: 363 VTRDGWLSLFMAAVVVPNTTLLPLLCIVML 392
           +         +  + +   T+ P + +V+L
Sbjct: 372 LHAPLAALTAVLELSLTAETMFPAMVVVVL 401


>UniRef50_A2BJY0 Voltage-gated chloride channel protein n=1 Tax=Hyperthermus
           butylicus DSM 5456 RepID=A2BJY0_HYPBU
          Length = 563

 Score =  109 bits (271), Expect = 3e-22,   Method: Composition-based stats.
 Identities = 71/403 (17%), Positives = 151/403 (37%), Gaps = 13/403 (3%)

Query: 6   ARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTL 65
            + ++L +L  V  G+A +L+ + +  IA +        L    G   +  L +  ++ L
Sbjct: 10  EKWVMLGTLVGVVSGLAGTLLTVGIEVIAELFAEYSGIDLIK--GEVSEPSLVLPLLVAL 67

Query: 66  TGIAVGLVIRFSQGHA---GPDPACEPLI--GAPVPPSALPGLIVALILGLAGGVSLGPE 120
            G+A GL+       A   G D   E     GA + P      + A    +  G S G E
Sbjct: 68  GGLASGLLTYMFAPEAEGHGTDSVLEAFHWRGAFIRPRVPLVKLAASSALIGLGGSAGKE 127

Query: 121 HPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSE 179
            PI  +       +   L L R  R    +   AG I A+F  P+  A++F+  +    +
Sbjct: 128 GPIALIGAGFGSVLADILHLTRNERRLLVLAGVAGGISAVFRAPL-GAMLFALEVPYKRD 186

Query: 180 VPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMV 239
           + + + +    +A+    + +         L +   G     +++  A++  +A     V
Sbjct: 187 MEV-EAILPLGVASIVAYVASVTILGSGRLLWLPEVGLQSSLELVLYAVLGIVAGLVAKV 245

Query: 240 AVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTS 299
            V     +      +  PV++    G ++     +  P +L +G   +++ +  +  +  
Sbjct: 246 YVRLFYEIRDAFKVLPIPVMLKPALGGLVAGFIGLLLPHTLGQGYPFLERALLGK-LALP 304

Query: 300 DYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAIT--VSCAIL 357
                 + K+     + ASG  GG   P++F+G  LG    +     PA I       + 
Sbjct: 305 VIVAAIIGKMLTNAFSIASGGSGGVFAPSLFIGGMLGAAFAQLYTDNPATIASFSVVGMA 364

Query: 358 GIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAG 400
                  +  + S+ + + +     L+    + +  ++++   
Sbjct: 365 AFFAAAGKVPFTSIIIVSEITRGYELIVPSVVAVTLSYVVSGQ 407


>UniRef50_D0R1Y7 Putative uncharacterized protein n=9 Tax=Lactobacillus
           RepID=D0R1Y7_LACJF
          Length = 397

 Score =  109 bits (271), Expect = 3e-22,   Method: Composition-based stats.
 Identities = 70/398 (17%), Positives = 145/398 (36%), Gaps = 17/398 (4%)

Query: 6   ARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTL 65
           A+  + + + +        ++  + + + + + + +W         +       +  +  
Sbjct: 2   AKKRINILIFSSIWSFIIGILTALYLNLINYIIDFIWGYFNHHNNFSLRPAYPFLICIPF 61

Query: 66  TGIAVGLVIRFSQGHAGPDPACEPLI--GAPVPPSALPGLIVALILGLAGGVSLGPEHPI 123
            GI +G +++    +          +     +   +        +L L  G S+GPE   
Sbjct: 62  -GIIIGFLVKKLGSYPLTIEEVLHDVRKSGKLDYHSWWKSFTLGLLSLGAGGSIGPEAST 120

Query: 124 MTVNIALAVAIGA--RLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVP 181
             +   +   +G   RL+    +              L  +P  + L  ++         
Sbjct: 121 TVLTSGMINWLGDKIRLMTTHYKSWVHFWQIGIDKDTLLQSPKFSELFRTKNQK------ 174

Query: 182 LWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIA-IAAGMVA 240
            W   F  L+      L   LF     +  I          IL  ++V  I  I      
Sbjct: 175 KWFITFNILIGLIGTILIFKLFPE-EGAFGIHERPIYWSWTILWYSLVPIIGGILFAYFF 233

Query: 241 VWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQ-AFSTS 299
           ++       +       +L   + G +L +L ++    +LF G   +        ++S  
Sbjct: 234 LYLEKTFTRVETWALPALLKATLWGIVLSVLTLVTN-YALFSGEFHIVSFSKTALSYSPL 292

Query: 300 DYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGI 359
              L+A+IK  +     A G+RGG+IFPA+F  VA+G  + + +P  P AITVS A++  
Sbjct: 293 FLLLIALIKTISTHAGFAMGWRGGKIFPAIFSSVAVGAAISQFIPIQP-AITVSLAVVAS 351

Query: 360 VLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLL 397
           + ++     L+  +   ++P  +L PL+ I      L+
Sbjct: 352 ITIILEKPLLTAVLLIFLLP-ISLAPLIFITAYIVMLI 388


>UniRef50_A9A065 Chloride channel core n=1 Tax=Desulfococcus oleovorans Hxd3
           RepID=A9A065_DESOH
          Length = 669

 Score =  109 bits (271), Expect = 3e-22,   Method: Composition-based stats.
 Identities = 74/408 (18%), Positives = 152/408 (37%), Gaps = 16/408 (3%)

Query: 4   PRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTL-GIAQDSPLWIIGV 62
           P     L L L A+ +G+ S L  + +  +      L +      L  + Q S    +  
Sbjct: 8   PLTNRHLNLILLALVVGVCSGLGAVAIRLMIKYGTLLFFGVYGNFLESVTQVSVARRLAA 67

Query: 63  LTLTGIAVGLVIRFSQGHA-----GPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSL 117
             L G+ VG +I F    A             L    +         +A  + +  G S+
Sbjct: 68  PMLGGLIVGPLIYFLAKEAKGHGVPEVMLAVLLRDGRIRKRVAFVKALASAITIGSGGSV 127

Query: 118 GPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNG 176
           G E PI+ +  +L   I  R  L + +        +AG I A F  P+A AL   + + G
Sbjct: 128 GREGPIVQIGSSLGSTIAQRFNLEKRDTATLVACGAAGGIAAAFNAPIAGALFAVEIILG 187

Query: 177 SSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAA 236
              V     L   ++++    +          +  +  Y      +++   ++ A+A   
Sbjct: 188 DFGVA---ALSPIIISSVISTIVARGLEGNLVAFSVPPYALNTPWELIPYTVLGAVAGLV 244

Query: 237 GMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAF 296
            ++ +  L R+       + P  +    G +L  +  +  P     G D +     + A+
Sbjct: 245 AVLFIVVLYRMEHAYDNWRFPEYLKPFTGGVLVAIICLAFPHMYGVGYDSING-ALHGAW 303

Query: 297 STSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLML----HEHVPAVPAAITV 352
                  +  +K+ A  +  ASG  GG   P++F+G ++G ++    H+  P    + T 
Sbjct: 304 PLWMLVAMVFMKIMATSITLASGGSGGVFAPSLFIGASVGGVVGTVTHQLFPQAATSGTY 363

Query: 353 SCA-ILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLA 399
           +   +  +V   T+    ++ +   +  +  ++P L    + + L+ +
Sbjct: 364 ALVGMGAVVAATTQAPITAIIIIFELTQDYHIIPPLMFSCIISTLVAS 411


>UniRef50_Q7NS08 Probable voltage-gated chloride channel family protein n=1
           Tax=Chromobacterium violaceum RepID=Q7NS08_CHRVO
          Length = 455

 Score =  108 bits (269), Expect = 4e-22,   Method: Composition-based stats.
 Identities = 72/419 (17%), Positives = 151/419 (36%), Gaps = 35/419 (8%)

Query: 9   MLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLT-G 67
            L   +P     I   L+  V     ++  +               SP W + +      
Sbjct: 27  QLRRQVPVWIAAILIGLVAYVF----ALGSHWSHDLF---FKAYDASPYWSLLITPAGLA 79

Query: 68  IAVGLVIRFSQGHAGP---------DPACEPLIGAPVPPSALPGLIVALILGLAGGVSLG 118
           +A+ ++ RF    AG          +P  E L        A  G ++  ++G++ G + G
Sbjct: 80  LAIWIMRRFFPSSAGGGIPQSIAALEPGMEKLREYCFTLKAAFGKVLLTLIGISSGATFG 139

Query: 119 PEHPIMTVNIALAVAIGARLLPRVNRMEWTIL--ASAGTIGALFGTPVAAALIFSQTLNG 176
            E PI+ V  A+  ++  +   R      + +    A  + A F  P+A  +   + +  
Sbjct: 140 YEGPIVQVGAAIKYSLNRKAAQRHEGAARSFILAGGAAGVAAAFNAPLAGIVFAIEEMGR 199

Query: 177 SSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAA 236
             ++         L++     LTT      +    I H         L+      +    
Sbjct: 200 IFDMRASS---TILLSVIVAGLTTFAINGNYSYFGIVHVAMDNQQAWLAIPACGVVGGLI 256

Query: 237 GMVAVWCLPRLHAMM------HQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQM 290
           G +A   L  L + +       +++ P+      G  L ++G++    +   G    + +
Sbjct: 257 GGLACRVLLALSSRLPGPLHGWRIRYPIRFAAGCGLALAVIGIVSHGSTFGTGYFRARDI 316

Query: 291 VANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAI 350
           +     +  DY    V+KL ++ V+  S   GG   P++ VG   GL + + +P +P ++
Sbjct: 317 IEGHGAALQDY---GVLKLISMFVSHISAVPGGMFAPSLAVGAGFGLNMSQLLPFLPQSM 373

Query: 351 TVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNRP 409
            V   ++G    +TR       +   +   + ++    I ++   L+ A    ++  R 
Sbjct: 374 VVLLGMVGFFAGMTRAPMTGFVIVMEMTDTSGMI----IPLMATALIAASVSRLVSRRA 428


>UniRef50_Q0TP43 Voltage-gated chloride channel family protein n=9 Tax=Clostridium
           perfringens RepID=Q0TP43_CLOP1
          Length = 519

 Score =  108 bits (269), Expect = 4e-22,   Method: Composition-based stats.
 Identities = 60/350 (17%), Positives = 127/350 (36%), Gaps = 17/350 (4%)

Query: 61  GVLTLTGIAVGLVIRFSQGHAGP-DPACEPLIGAPVPPSALPGL---IVALILGLAGGVS 116
            VL   G  VG++++ +    G   P  E  +   +  + L       +  I+ +A G+S
Sbjct: 65  LVLIFLGFIVGIIVKKNPMIGGSGIPQVEGELSGKISVNWLRVFKDKFIGGIICMASGLS 124

Query: 117 LGPEHPIMTVNIALAVAIGARLLPRVNRMEWTILASAG-TIGALFGTPVAAALIFSQTLN 175
           LG E P + +  ++                  I   A   +  +F  P++ A+   + ++
Sbjct: 125 LGKEGPSVQIGASIGEGFAKIFKRSDFEKRLLITGGASSGLAVIFNAPLSGAIFALEEVH 184

Query: 176 GSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIA 235
            S  +P+   + A L A+  G     L     F + I     + +    +  I+ AI   
Sbjct: 185 RSFSLPV---MLAALSASLTGVFVDNLILGNDFCIKIPPINSLPIQYYWTLLILGAILGV 241

Query: 236 AGMVAVWCLPRLHAMMHQM--KNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVAN 293
            G +    L +      +   K P+    I  F++  +  +  P ++  G   ++ ++ N
Sbjct: 242 TGWIFNKGLLKTQDFYVKTLKKIPIQFKTIIPFVMVGILALTIPEAIDGGDSLIESVIGN 301

Query: 294 QAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEH------VPAVP 347
              +     ++ VIK      + +SG  GG  FP + +G  +G +          +    
Sbjct: 302 N-IAIKLLIVILVIKFIFTFFSYSSGVPGGIFFPLLAIGALVGAIFGLLLNKYLGISDSL 360

Query: 348 AAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLL 397
               +  A+      + +     L +   +      L  + I +  A+L+
Sbjct: 361 IVNFIVLAMAAQFASIVKAPITGLMLITEMTGTFKHLLPVAITVTVAYLV 410


>UniRef50_B0SCJ7 Chloride channel protein n=2 Tax=Leptospira biflexa serovar Patoc
           RepID=B0SCJ7_LEPBA
          Length = 604

 Score =  108 bits (269), Expect = 5e-22,   Method: Composition-based stats.
 Identities = 77/431 (17%), Positives = 150/431 (34%), Gaps = 38/431 (8%)

Query: 12  LSLPAVAIGIASSLILIVVMKIASVLQNLLWQRL----PGTL----------GIAQDSPL 57
           + + ++ IG+ S           +  ++  +  L    PGT            +A  SPL
Sbjct: 19  IYVFSLLIGLLSGFGAYGFNWALTWTESFTFGNLIGYDPGTPAGDLNFHSVGTVAVLSPL 78

Query: 58  WIIGVLTLTGIAVGLVIRF---SQGHAGPDPACEPLI--GAPVPPSALPGLIVALILGLA 112
           WI+ +  + G+ VG++  F        G D            +         +A IL L 
Sbjct: 79  WILFLPAIGGLLVGIITSFFCPEAQGGGTDSLIHSFHFNEGKIHTKVPFFKAIATILTLG 138

Query: 113 GGVSLGPEHPIMTVNIALAVAIGARLLPRVN-RMEWTILASAGTIGALFGTPVAAALIFS 171
            G S G E P   +      ++   L      R    +  +AG +GA+F  P+  A+   
Sbjct: 139 SGGSGGKEGPTAQIGAGFGSSLANFLGAGARARRTLMLAGTAGGLGAIFRAPLGGAITAV 198

Query: 172 QTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAA 231
           + +         D L   ++++    LT            +  Y   +   I    ++  
Sbjct: 199 EMVYQEDIE--SDSLVPCILSSVTAYLTYTSIAGSGSIFSVQEYSLNDYRHIPLYIVLGL 256

Query: 232 IAIAAGMVAVWCLPRLHAMMHQMKNP-VLVLGIGGFILGILGVIGGPVSLFKGLDEMQQM 290
           +    G   V     +  +  ++  P  L    GG I+G + ++  P  L  G   +Q+M
Sbjct: 257 LCYVVGYFFVKVYHFVQDIFSKLPLPNYLKPAFGGLIVGCIALL-FPEVLGSGFGLIQRM 315

Query: 291 VANQAFSTS--------DYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEH 342
           +  +  +++            +A+ K+ +  +   SG  GG + P+  +G  LG  +   
Sbjct: 316 INGEVLTSTSFGFSGPFFLLAVAIFKVFSTSLTVGSGSSGGLLGPSFAIGGMLGAFVGTM 375

Query: 343 VPAVPAAITVS------CAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWL 396
              +   + +         +      V R     + M   ++ +  LLP L IV + A +
Sbjct: 376 ANVLFPELNIIVFPFLLVGMGSFFAGVARAPIAGMIMVCDMIGSYALLPALMIVSMIAVV 435

Query: 397 LLAGKPMMMVN 407
           L     +    
Sbjct: 436 LSHKISIYRNQ 446


>UniRef50_C8WVL6 Cl-channel voltage-gated family protein n=1 Tax=Alicyclobacillus
           acidocaldarius subsp. acidocaldarius DSM 446
           RepID=C8WVL6_ALIAD
          Length = 584

 Score =  108 bits (269), Expect = 5e-22,   Method: Composition-based stats.
 Identities = 80/403 (19%), Positives = 149/403 (36%), Gaps = 16/403 (3%)

Query: 2   LHPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPG--TLGIAQDSPLWI 59
           L  R    ++L L AVAIG+ +    +   K+  +L  L +        +    D   + 
Sbjct: 30  LTSRLPERVILLLYAVAIGVVAGYGAVGFRKLIDLLDWLFFHVGTSYLRVLGRGDVIFFP 89

Query: 60  IGVLTLTGIAVGLVIRFSQGHA-GPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLG 118
              L +  + V      ++GH      A     G  + P  +    VA  L +  G S+G
Sbjct: 90  AIGLVIVSMLVRRFAPEAKGHGVPEVMAAIAERGGVIRPRVVVVKAVASALTIGSGGSVG 149

Query: 119 PEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGS 177
            E PI+ +  A     G  L +P+          +   I A F  P+   +  ++ + GS
Sbjct: 150 REGPIVQIGSAFGSVFGQMLGVPKRYLRLMVACGAGAGIAATFNAPIGGVMFAAEVILGS 209

Query: 178 SEV-PLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAA 236
             +      + + +++AA G +   L  HP F +PI   G           ++  ++   
Sbjct: 210 FALENFTAIMMSSVVSAAIGRIY--LGNHPSFDIPIHDVGPFR--AYWVYVLLGLVSGLW 265

Query: 237 GMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAF 296
           G + V  L R+       + P  V  + G I   +  +  P     G   + +   +   
Sbjct: 266 GTLYVKVLYRVEDWFDARRWPFWVKAVVGGIAVGVIGVWFPQIFGVGYGTIDR-ALSAHL 324

Query: 297 STSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLML-----HEHVPAVPAAIT 351
                  L V+KL A  +   +G  GG   P ++ G  LG ++     H H+   P A+ 
Sbjct: 325 PLYLLGTLLVLKLLATSITIGAGGSGGVFSPGLYQGAMLGGLVGVMLSHAHIAVSPGALA 384

Query: 352 VSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPA 394
               + G+     +    S+ M   +  + +++  L I  + +
Sbjct: 385 AIG-MAGVFAGSAQAPVTSITMLFEMTGDYSMILPLMITSVLS 426


>UniRef50_Q12WA6 Voltage-gated ClC-type chloride channel n=5 Tax=Methanosarcinaceae
           RepID=Q12WA6_METBU
          Length = 577

 Score =  107 bits (268), Expect = 6e-22,   Method: Composition-based stats.
 Identities = 78/381 (20%), Positives = 141/381 (37%), Gaps = 29/381 (7%)

Query: 16  AVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIR 75
           A+ IGI + L ++         +++ W            S   +I +  + G+ VG+++ 
Sbjct: 26  AILIGIFTGLTIVAYNICLKYAEDIFWS------NSDITSSYIVILIPAIGGLLVGIIVF 79

Query: 76  FSQG----HAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALA 131
           FS      +         L G  +        +V  I+ +A G S+G E P +     + 
Sbjct: 80  FSGDIHRCNVPEVIEGTALHGGRISVRGAFREVVLSIISIATGGSVGKEAPGILAGSGIG 139

Query: 132 VAIGARLL-PRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPL 190
                 L  P           +AG I A F  P+A  +   + + G  E          +
Sbjct: 140 SIFAKALKAPDHRYRTLIGCGAAGGIAAAFNAPLAGVVFVVEVILGELET---RTFIPIV 196

Query: 191 MAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRL--- 247
           ++A    L   L F     + I++YG ++   I    +   +    G+ +V  +  L   
Sbjct: 197 ISAVFATLVANLIFEVK-PIQISYYGLVD--PIGESILYLILGTLCGITSVLLIRTLFTV 253

Query: 248 HAMMHQMK-NPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAV 306
           H    ++  +      IGG ++G++G    P     G D +  ++ N +F+     +L V
Sbjct: 254 HDGFSKLPIHSAFKPAIGGLLVGLMG-YFYPQIRGIGYDVIADVLTN-SFTIQLLLVLFV 311

Query: 307 IKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLVVTRD 366
           +K+ A      SG  GG I P++F G  LG      V ++    T +     +V      
Sbjct: 312 LKILAFSFTIGSGGAGGSIVPSMFAGAMLGGAYGTLVHSIFPTSTAAAGAYALV------ 365

Query: 367 GWLSLFMAAVVVPNTTLLPLL 387
           G  +        P T +L L 
Sbjct: 366 GMGATLAGTARAPLTAVLILF 386


>UniRef50_B5CM99 Putative uncharacterized protein n=1 Tax=Ruminococcus lactaris ATCC
           29176 RepID=B5CM99_9FIRM
          Length = 424

 Score =  107 bits (266), Expect = 9e-22,   Method: Composition-based stats.
 Identities = 75/403 (18%), Positives = 145/403 (35%), Gaps = 26/403 (6%)

Query: 13  SLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGL 72
           S+ A+  G+A   I  +        + LLW               +++  L + G+ +  
Sbjct: 12  SILALVTGVAVGAIDTIF------GRGLLWLSD-----FRTAHYRYLLPFLPVAGLLIVW 60

Query: 73  VIRF----SQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNI 128
           +       S                 +P + +P +IV   L    G S G E   + +  
Sbjct: 61  MYHRFSEESLKGMTLVLETGQKKRKSIPLALVPLVIVGTWLTHLFGGSAGREGVAVQIGA 120

Query: 129 ALAVAIGARLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFA 188
            ++   G +     N     +   A   G LF TP+AA     + +  +S    ++ L  
Sbjct: 121 VISHEAGKKFRCPENDRIMLVAGMAAGFGGLFQTPLAAVFFAMEVI--ASGYMQYEALLP 178

Query: 189 PLMAAAAGALTTGLFFHPHFSLPIAH-YGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRL 247
            +++A   A T+ +     F+  I       E   ILS  ++  +    G +    L  +
Sbjct: 179 AMISAYTAAFTSHILGLEKFTAVIGEKLDLSETKVILSLIVLGILFGLVGRLFSGTLQWM 238

Query: 248 HAMMHQ-MKNPVLVLGIGGFILGILG-VIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLA 305
              M   +KNP + +G     L +L  +  G      G + +     N      D+    
Sbjct: 239 KKRMGNAIKNPYIRIGAVAVFLAVLLFLFHGGRYSGLGTNLISAAFENGTIYGYDW---- 294

Query: 306 VIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLVVTR 365
           ++KL   V+  A GF+GG + P   +G +LG++    +   P  +  +     +    T 
Sbjct: 295 ILKLGFTVLTLAIGFQGGEVTPLFSIGASLGILAGNLLGISPV-VCAALGYAAVFGSATN 353

Query: 366 DGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNR 408
                + +   V      +PL+ + +L A+L+  G  +    +
Sbjct: 354 TLLAPVMIGLEVFGTENAIPLVVVCIL-AYLMNGGSSIYTAQQ 395


>UniRef50_A5UNZ8 Voltage gated chloride channel protein/cation transporter, TrkA
           family n=2 Tax=Methanobrevibacter smithii
           RepID=A5UNZ8_METS3
          Length = 522

 Score =  107 bits (266), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 76/414 (18%), Positives = 152/414 (36%), Gaps = 20/414 (4%)

Query: 7   RTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLT 66
           + +  L++  + +GI + +++ +   +    +++L   L    G       W I +L + 
Sbjct: 16  KHIFKLAVQGIFVGIFAGIMVCLYRFLLYSSESILRNFLEFINGNIFLIIAWFI-ILAIL 74

Query: 67  GIAVGLVIRFSQGHAGP-DPACEPLIGAPVPP---SALPGLIVALILGLAGGVSLGPEHP 122
           G+    ++++     G   P     +   +       L   I A +L   GG+SLGPE P
Sbjct: 75  GLFTAFLVKWEPDSIGSGIPQINAEVKGFLNTNWLKILTAKISAGVLTALGGLSLGPEGP 134

Query: 123 IMTVNIALAVAIGARLL-PRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVP 181
            + +       I       R + +   +  S   I A F  P+A  +   + +N S +  
Sbjct: 135 SVQIGGMAGKGISRIFKESRTDELRLILAGSTVGITAAFNAPLAGVIFIIEEINHSFDKT 194

Query: 182 LWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAV 241
           L   +F  L A+      +  FF     L    +     +  L   +   + I   +  V
Sbjct: 195 L---IFIALTASVVADFISKSFFGQATVLNFPLHNLPLSSYWLLIVLGLLLGILGYVYNV 251

Query: 242 WCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDY 301
             +     +      P+ +  I  F++  +  +  P  L  G   +  +           
Sbjct: 252 GMIRANDRLAKMSNIPLEIKFICVFLISGVVALFIPEILDGGHFMLDMLDVAIPPLGILI 311

Query: 302 FLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAIT------VSCA 355
           FLL V K    VV+ ++G  GG   P + +G  +G +    V  +    +      +  +
Sbjct: 312 FLL-VAKYLFSVVSFSAGTPGGIFLPLLVLGAFIGAIFGSVVIPIFGLESYLIYKFIVIS 370

Query: 356 ILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNRP 409
           + G      R     + + + +  +T  L  + IV + A+      PM++ NRP
Sbjct: 371 MAGFFAATVRSPITGVVLLSEMCGSTESLVAMLIVAIIAY----AVPMLLNNRP 420


>UniRef50_Q0BQZ9 Chloride channel protein n=4 Tax=Acetobacteraceae
           RepID=Q0BQZ9_GRABC
          Length = 479

 Score =  107 bits (266), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 83/394 (21%), Positives = 141/394 (35%), Gaps = 30/394 (7%)

Query: 21  IASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVI--RFSQ 78
           +A SL  I   K+A   Q                   WII +L   G+ V  ++      
Sbjct: 59  VAVSLTAIAFAKLADRAQ--------DVFSAVIAHGAWIILILAPCGLVVSFLLARHVFP 110

Query: 79  GHAGP---------DPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIA 129
           G  G          D A    +   +      G I+  +LGLA G S+G E P + V  +
Sbjct: 111 GSQGSGIPQVIASLDLADVRQVDRILSLRIAVGKILLTLLGLASGASIGREGPTVQVGAS 170

Query: 130 LAVAIGARLLPRVN--RMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLF 187
           +  A+G  L       R    +   A  I A F TP+A  +   + L+ S E        
Sbjct: 171 VMHALGRLLHLPTPELRRSVVLAGGAAGIAAAFNTPLAGIVFAIEELSHSYEARTSGNTL 230

Query: 188 APLMAAAA------GALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAV 241
           A ++ +        G  +             +    M +  +L G +  + +      A 
Sbjct: 231 AAVVISGVVTIALVGNYSYFGHIDATMRFGPSEVMAMVICAVLGGLLGGSFSALLIRAAK 290

Query: 242 WCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDY 301
                L  ++ Q   PVL   + G I+ I G++    +   G ++ + MV      T   
Sbjct: 291 GFPGALGRLVKQY--PVLFAALCGLIVAITGLLSHGETYGTGYEQARDMVTGLPGDTEG- 347

Query: 302 FLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVL 361
              A++KL A   +  SG  GG   P++ +G  LG  +   VP + A   V   ++    
Sbjct: 348 LKFALLKLVASAASYLSGIPGGIFAPSLAIGAGLGEWVARLVPGLAAGSVVLLGMVAYFS 407

Query: 362 VVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAW 395
            V +    +  +   +  N ++L  L    + A+
Sbjct: 408 GVVQAPITAAVIVMEMADNQSMLIPLMATSMMAF 441


>UniRef50_A7HVW3 Chloride channel core n=1 Tax=Parvibaculum lavamentivorans DS-1
           RepID=A7HVW3_PARL1
          Length = 629

 Score =  106 bits (265), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 92/402 (22%), Positives = 150/402 (37%), Gaps = 27/402 (6%)

Query: 5   RARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLW----QRLPGTLGIAQDSPL--W 58
           R   M++LSL A+A+G+A+ +  ++   +   L NL +       P +      SPL   
Sbjct: 46  RQVNMVVLSLLALAVGLATGVGAVIFRSMLVGLHNLFFFGQLSLTPTSGATGPLSPLGAL 105

Query: 59  IIGVLTLTGIAVGLVIRF--SQGHAGPDPACEPLI---GAPVPPSALPGLIVALILGLAG 113
           II V  L GIAV  + R    +   G        +      + P       +A  L +  
Sbjct: 106 IILVPVLGGIAVVWITRRFAPEAKGGGITDVMDAVYHREGKIRPRVAVVKTIASALSIGS 165

Query: 114 GVSLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQ 172
           G ++G E PI+ +  A+  AI     LP   R+      ++  I A F TP+ A L   +
Sbjct: 166 GATVGREGPIVQIGSAIGSAIAQFSRLPSWQRITLLAAGASAGISATFNTPLGAVLFALE 225

Query: 173 -TLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAA 231
             L   S       + A   A   G +  G   +P F LP   +   EM  I +      
Sbjct: 226 LILPEISARTFLPVVIATGSATYVGRVVFG--SYPAFVLPQMSFATSEMDHIFNLGAFVV 283

Query: 232 IAIAAGMVAVWCLPRL----HAMMHQMKNPVLVLGIGGFILGILGVIG-----GPVSLFK 282
           + + +G+VA   L  L      M  +  N  +    G   +GI   +          +  
Sbjct: 284 LGLMSGLVAWGFLRTLLFAGDVMPRRFPNEYMRAAAGFTGIGIALFLFAHFTGHYYIIGG 343

Query: 283 GLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEH 342
           G D +  ++     S      L V ++ A  ++  SG  GG   P +F+G +LG      
Sbjct: 344 GYDAIAAILEGHVTSFLLLAALCVAQVFATSLSIGSGASGGVFAPMLFIGASLGGAFGAL 403

Query: 343 V---PAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNT 381
           +    A         AI+G+  VV      ++    +    T
Sbjct: 404 LHIFDADHGIGVADYAIIGMAAVVGGGTGAAMTAITMNFEMT 445


>UniRef50_Q39PZ5 Cl-channel, voltage gated n=4 Tax=Desulfuromonadales
           RepID=Q39PZ5_GEOMG
          Length = 613

 Score =  106 bits (265), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 69/384 (17%), Positives = 139/384 (36%), Gaps = 18/384 (4%)

Query: 5   RARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSP----LWII 60
           R     L+++ AV IG+ + L            + L+        G + D+     LW +
Sbjct: 43  RISESTLMAVLAVGIGLLAGLCNYAFRSCIDFFRWLIIDNGARLTGYSPDTWDASRLWAL 102

Query: 61  GVLTLTG-IAVGLVIRFSQGHAGPDPACEPLI---GAPVPPSALPGLIVALILGLAGGVS 116
               +   I + L I + +  A   P     +   G  +P   +    ++  L +  G S
Sbjct: 103 AFPVIGATIMLPLFIWYREDMAFGFPRFLERVNLRGGRLPLRLMFTRGISSALTIGSGGS 162

Query: 117 LGPEHPIMTVNIALAVAIGARLLPRVNRMEWTI-LASAGTIGALFGTPVAAALIFSQTLN 175
            G E PI  +       +G  L     R++  I    +G + A F  P+A      + + 
Sbjct: 163 AGQEGPIAQIGGTAGSVVGHLLGMPEERLKVLIGCGVSGGVAATFNAPLAGVFFAHEIVL 222

Query: 176 GSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIA 235
            SS         + ++++    + +   +    +  +  Y  +   +++  A++  +   
Sbjct: 223 LSSFE--LSSFTSIVISSGMATVVSRAMYGDIPAFDVPAYQLVHPLELVLYALLGIVCGC 280

Query: 236 AGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQA 295
              + +    +      Q++   L   + G  L     +  P     G   +++ V N  
Sbjct: 281 VAALFITGYGKTREFFEQLRVNPLWKPLLGGFLAGCVGVLLPQVQGNGYGFIEKAVGN-D 339

Query: 296 FSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLM---LHEHVPAVPAAITV 352
                  LL V K+AA  V   SG  GG   P++F+G   G+    L   +  +  A   
Sbjct: 340 VGWLLVTLLIVGKMAATCVTIGSGLPGGTFAPSLFIGSVTGMSFGFLANLLFPLHTATPG 399

Query: 353 SCAILGI---VLVVTRDGWLSLFM 373
           + A++G+   +  VT      +F+
Sbjct: 400 AYALVGMGAFLASVTHAPMTGIFL 423


>UniRef50_B2UN00 Chloride channel core n=1 Tax=Akkermansia muciniphila ATCC BAA-835
           RepID=B2UN00_AKKM8
          Length = 595

 Score =  106 bits (265), Expect = 1e-21,   Method: Composition-based stats.
 Identities = 77/387 (19%), Positives = 144/387 (37%), Gaps = 22/387 (5%)

Query: 14  LPAVAIGIASSLILIVVMKIASVLQ---NLLWQRLP-GTLGIAQDSPLWIIGVL--TLTG 67
           + AV +G+  S + +    +  V+Q     +W     GT  + +      I V    + G
Sbjct: 36  VWAVLVGMVGSCMSLFFEWMVEVIQWMLTGIWSDSRVGTFSLVEPEWRMFIPVAGGLVAG 95

Query: 68  IAVGLVIRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVN 127
             +  + +   G A        +    +   A    + +    +A G ++G E PI+  +
Sbjct: 96  CILLFLKKRMPGQAMEYMEAMSIGNGLIKFRASALKVFSAAWSIASGAAIGKEGPIIQSS 155

Query: 128 IALAVAIGARLLPRVNRMEWTI-LASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRL 186
             +A  +G RL   + R+   +   +A      F  P +  L  S+ + G+  +   D L
Sbjct: 156 ALIASTVGQRLHVSIPRLRLLVGCGAAAGFTTAFHAPFSGCLFVSEIIIGTVSM---DIL 212

Query: 187 FAPLMAAAAGALTTGLFFHPH--FSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCL 244
              L+A+  G +   L   P   +S P   +     +        AA   A G V++   
Sbjct: 213 APLLIASCTGFVMLHLLGDPSPLYSSPFESFTVFSQSLWCIALGAAAAVAARGWVSL-LD 271

Query: 245 PRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLL 304
                +  +     L L   G ++GIL V   P  +  G   +  +V    + T +  +L
Sbjct: 272 AAARYLNGRQSLLPLRLAAAGLVVGILAVFY-PEVVGNGQALITGLVHE-DYGTREALVL 329

Query: 305 AVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLVVT 364
            ++K++A+ V    G  GG + P ++VG  +G +    +       T         +   
Sbjct: 330 LLVKVSAVAVVFGCGTVGGAMTPTLYVGSMVGFIFSTVL-------TSLGMEGNHTVAYA 382

Query: 365 RDGWLSLFMAAVVVPNTTLLPLLCIVM 391
             G  S F  A   P T L+ ++   M
Sbjct: 383 MVGMASFFAVAAQAPLTALVMVVEFSM 409


>UniRef50_B3PL72 Voltage-gated chloride channel n=1 Tax=Cellvibrio japonicus Ueda107
           RepID=B3PL72_CELJU
          Length = 580

 Score =  106 bits (264), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 57/319 (17%), Positives = 105/319 (32%), Gaps = 24/319 (7%)

Query: 89  PLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARL-LPRVNRMEW 147
                 +P              L  G S+G E P + +       +G  L LP  +    
Sbjct: 118 QNHQGRMPWGNFSVQFWGGATCLLSGQSVGREGPAVHLGAGAGSLLGQWLKLPGNSLRPL 177

Query: 148 TILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPH 207
                A  I A F TP+A  +   + +     +         ++AA AG   + L F   
Sbjct: 178 AGCGVAAAIAACFNTPMAGVIFAMEVVMMEYTIA---GFIPVILAAVAGTTISHLAFGNV 234

Query: 208 FSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMM--HQMKNPVLVLGIGG 265
            +  +          +L   +V    +   ++A   + RL A    H + +PVL+     
Sbjct: 235 INFELLQSDH---AGLLELPLVILAGLFIALLAAAYI-RLQAFWCRHSLNHPVLLRFAIA 290

Query: 266 FILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRI 325
            +L  L     P  +  G D + Q +            + + KL     A   G  GG I
Sbjct: 291 GLLTGLVAYAFPHIMGVGYDTINQALQGN-LGFWLLLGILIAKLFVTTAALGLGMPGGVI 349

Query: 326 FPAVFVGVALGLMLH----EHVPAVPAAIT--VSCAILGIVLVVTRDGWLSLFMA----- 374
            P +F+G   G  +       +P   + I   V   +  ++         ++        
Sbjct: 350 GPLLFIGACAGGAIGIIANNLMPGSASHIGFYVVLGMGAMMGATLNAPMAAMMAIIELTY 409

Query: 375 --AVVVPNTTLLPLLCIVM 391
             A++ P+  ++ + C+  
Sbjct: 410 NPAIIFPSMLMVVVACLST 428


>UniRef50_Q02Z91 Chloride channel protein EriC n=4 Tax=Lactococcus lactis
           RepID=Q02Z91_LACLS
          Length = 403

 Score =  106 bits (264), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 81/386 (20%), Positives = 146/386 (37%), Gaps = 21/386 (5%)

Query: 19  IGIASSLILIVVMKIASVLQNLLWQRLPGT-----LGIAQDSPLWIIGVLTLTGIAVGLV 73
           +GI+ S IL V + +       +   + G              L++I  LTL G+ +  +
Sbjct: 6   VGISRSAILYVFLAVIIGGLIGVVDAIFGRGLIYITEFRDGHALYLIPFLTLAGLLIVYL 65

Query: 74  IRF----SQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIA 129
            +     SQ   G            +P   +P ++ +  L    G S+G E   + +   
Sbjct: 66  YKNFGKDSQKGMGLIFEAGNHGREDIPKRLVPLIVFSTWLSHLFGASVGREGVAVQIGGV 125

Query: 130 LAVAIGARLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAP 189
           +  AIG +L  +  +    I   A    ALF TP+AA     + L        +  L   
Sbjct: 126 IGHAIGKKLSAKEAKKILLITGMAAGFAALFQTPIAATFFAIEILM--LGKIEYRALIPA 183

Query: 190 LMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHA 249
           L+ +   + T+       FS  I     ++   +L  AI+A      G      L  + A
Sbjct: 184 LVGSYVASWTSNYLGLEKFSFAINTNIHLDPLVLLKLAIIAVCFGLVGRFFAESLAFMKA 243

Query: 250 -MMHQMKNPVLVLGIGGFILGI-LGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVI 307
            +  ++ NP   + + G ++ I L VI        G + +         +  D+    ++
Sbjct: 244 TVAKRIANPYQRIILMGIVISIGLLVIHMDRYAGLGTNLIGLSFNGGHINGYDW----IL 299

Query: 308 KLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLVVTRDG 367
           KL   V++ ++GF+GG + P   +G  LG  L      +P     +   + I    T   
Sbjct: 300 KLIFTVLSISAGFQGGEVTPLFAIGSTLGAALAMLF-GLPVEFVAAAGYVSIFSAATNSY 358

Query: 368 WLSLFMAAVVV---PNTTLLPLLCIV 390
           +  +F+AA V        +LP++ I 
Sbjct: 359 FGPIFIAAEVFGFGSVQYILPIMTIA 384


>UniRef50_B2KDW6 Chloride channel core n=1 Tax=Elusimicrobium minutum Pei191
           RepID=B2KDW6_ELUMP
          Length = 494

 Score =  106 bits (264), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 56/320 (17%), Positives = 114/320 (35%), Gaps = 10/320 (3%)

Query: 93  APVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILA 151
            P+   +        +L ++ G S G E P   V   LA      L L   +R +  I  
Sbjct: 88  KPISLISAAKAFFLPVLTISAGGSAGKEAPCADVGAGLASFSARLLKLSNEDRRKLMICG 147

Query: 152 SAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLP 211
            +     +FG P++ A+   + L        ++ +F  L+A       T      +   P
Sbjct: 148 VSAGFAGVFGVPISGAIFGLEVL--WVGYIFYEVMFPALVAGITAYQVTSALGVTYIYHP 205

Query: 212 IAHYGQMEMTDILSGAIVAAIAIAAGMVAVWC---LPRLHAMMHQMKNPVLVLGIGGFIL 268
           I           L             ++ +        +   +    +       GG IL
Sbjct: 206 IPVVPVFTEGFFLKILFAGLFFGLISLLFIEIMKLFRVVFRYISIKFSFFWKAFTGGAIL 265

Query: 269 GILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPA 328
             +G++  P  L  G++E   ++   A  +  + L ++ K+    +  ++G  GG + P 
Sbjct: 266 VAVGLLLSPEFLGLGMEETNAILHGSAEPS--FALGSLFKMITTAITFSAGGVGGIVTPI 323

Query: 329 VFVGVALGLMLHEHVPAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLC 388
            F+G   G +L E +   PA +     +   VL    +  L+  + A+ +    + P   
Sbjct: 324 FFIGSQAGAVLGEFLQIDPATVAALGVVA--VLAGATNAPLASSIMAIELFGPQIAPYAA 381

Query: 389 IVMLPAWLLLAGKPMMMVNR 408
           +  + ++L+   + +    R
Sbjct: 382 VCCVISFLVTGQRSVFAKQR 401


>UniRef50_A0NVL9 Cl-channel, voltage gated n=2 Tax=Alphaproteobacteria
           RepID=A0NVL9_9RHOB
          Length = 604

 Score =  106 bits (263), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 82/426 (19%), Positives = 161/426 (37%), Gaps = 27/426 (6%)

Query: 5   RARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQ------RLPGTLGIAQDSPLW 58
           R  ++ LL L A  IGI +++  +    + S++ NL +                      
Sbjct: 24  RVFSVPLLCLVAFFIGIVAAIGAVFFRYLISIVHNLFYYGKFSTVYDANQFADPSPLGAL 83

Query: 59  IIGVLTLTGIAVGLVIR-FSQGHAGP-DPACEPLI-GAPVPPSALPGLI--VALILGLAG 113
           +I V  + G+ V  ++R F+    G   P     I         +  L+   A  + +  
Sbjct: 84  VILVPVIGGLIVVFLVRTFAPEAKGHGVPEVMFAIYHKKGDVRGVVALVKSFASAISIGT 143

Query: 114 GVSLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQ 172
           G S+G E PI+ +  +    I   L LPR  ++      +   I A F TP+   L   +
Sbjct: 144 GASVGREGPIIQIGASFGSTIARALHLPRWQKITLLSAGAGAGIAATFNTPLGGVLFAVE 203

Query: 173 TL-NGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAA 231
            L    S       + A   A  AG +  GL   P F +PI+    +E  + +     A 
Sbjct: 204 MLLPEVSNRTFLPVVVATATATYAGRIAFGL--DPAFIVPISAEEAIEAIEPIQLGAYAL 261

Query: 232 IAIAAG---MVAVWCLPRLHAMMHQMKNPVLVLGIGGFIL------GILGVIGGPVSLFK 282
           + + AG      +  L     +  ++        I G ++       ++   G   +   
Sbjct: 262 LGVLAGVASWAFIRTLAWCEDLFPKLPGNDYTQNIIGMLIIGTLSYVLMLTTGHYHTAGV 321

Query: 283 GLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLH-- 340
           G   +Q ++ +  ++     +L V K+ A  ++  +G  GG   P++F+G  LG M+   
Sbjct: 322 GYATIQDILNSTPYTLILLAVLFVAKIIATSISLGAGASGGVFSPSLFIGATLGGMVGVL 381

Query: 341 -EHVPAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLA 399
             H+        V  A++G+  +V      S+    ++   T    ++  ++L   + + 
Sbjct: 382 CSHLFPDSGFTAVEFALVGMGALVGGATGASMTAIVMIFEMTRDYNVIVPLVLAVAIAVG 441

Query: 400 GKPMMM 405
            +  ++
Sbjct: 442 IRRWLI 447


>UniRef50_A0NVM0 Cl-channel, voltage gated n=4 Tax=Alphaproteobacteria
           RepID=A0NVM0_9RHOB
          Length = 550

 Score =  106 bits (263), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 72/357 (20%), Positives = 130/357 (36%), Gaps = 12/357 (3%)

Query: 11  LLSLPAVAIGIASSLILIVVMKIASVLQ-NLLWQRLPGTLGIAQDSPLWIIGVLTLTGIA 69
           ++ L A+ IG   S   IV  +I S++Q   L       +  A   P ++I      G  
Sbjct: 36  IVWLLALLIGSFVSWAAIVFREIISLVQLPWLGTATERVVSAAATLPWYVIVAGPTIGGL 95

Query: 70  VGLVIRFSQGHAGPDPACEPLIGAPVPP----SALPGLIVALI--LGLAGGVSLGPEHPI 123
           +  ++           +   +I A V         PG+  ALI  L L  G S G E P+
Sbjct: 96  LVGLLLQYMQPMQRTFSVADVIEARVKGGRGLPFWPGISSALITALSLGFGASAGREGPV 155

Query: 124 MTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPL 182
           + +   +  ++G    LP            A  + A F  P+A  L   + + G   +  
Sbjct: 156 VHLGATIGASVGRLFQLPDSAHRILLACGVASAVSASFNAPIAGVLFAHEVILGHYAM-- 213

Query: 183 WDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVW 242
              +    +AA  G + + L+F    +  I  +      +  + A++  ++    ++  +
Sbjct: 214 -SAISPIAIAAVTGTVFSRLWFGDVAAFVIPGHQITSYWEFPAFALLGMVSALVAILFQF 272

Query: 243 CLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYF 302
            L         +  PV +  + G  +  L  +  P  L  G +     + +Q        
Sbjct: 273 ALIGTDWFARNISMPVWLRPVTGGFVVGLIALVFPDVLGVGYETTDAALKDQLPLVMLL- 331

Query: 303 LLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGI 359
            L V K AA  +  AS F GG   P++++G   G        +V   +  S  +  I
Sbjct: 332 ALLVAKTAATAITLASRFGGGIFSPSLYLGAMTGGAFGLIAASVFPELASSEGLYAI 388


>UniRef50_C9LB15 Voltage-gated chloride channel family protein n=13
           Tax=Clostridiales RepID=C9LB15_RUMHA
          Length = 527

 Score =  106 bits (263), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 69/407 (16%), Positives = 145/407 (35%), Gaps = 17/407 (4%)

Query: 6   ARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTL 65
            R   +L+     +G  + L++++   I       + + L         + LW + +  +
Sbjct: 19  ERFKTILTAEGFLVGAVAGLVVLLYRVILEYAGKGMNKVLEYARQEPFAAVLWFVALFVI 78

Query: 66  TGIAVGLVIRFSQGHAGP-DPACEPLIGAPVPP---SALPGLIVALILGLAGGVSLGPEH 121
               VG ++++    +G   P  E  +   +       LP   +   L L  G+SLG E 
Sbjct: 79  A-CIVGKLVKYEPMISGSGIPQVEGEMMGKLNQVWQRVLPAKFLGGFLSLFAGLSLGREG 137

Query: 122 PIMTVNIALAVAIGARLLPRVNRMEWTI-LASAGTIGALFGTPVAAALIFSQTLNGSSEV 180
           P + +      A+   L       ++ I   ++  + A F  P+A  +   + ++ +  V
Sbjct: 138 PSIQIGAMTGKAVSQTLDRGKTEEKYLITCGASAGLAAAFHAPLAGVMFSLEEIHKNFSV 197

Query: 181 PLWDRLFAPLMAA-AAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMV 239
            +   +    + A    +   G      F +      Q     ++ G I+  +      +
Sbjct: 198 SVLISVMTASITADYISSQFMGFQPVFQFDVGTEMPPQYYWHIVILGVILGIMGAFYNKM 257

Query: 240 AVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTS 299
            +W       +  +  N    L I  F+ G+LG++  P  L  G   +  M A      +
Sbjct: 258 TMWVQGLY--LKSKKLNETTRLFIPFFLAGVLGLV-MPQILGSG-HALIDMAAEGNLMLT 313

Query: 300 DYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEH------VPAVPAAITVS 353
              +L   K    ++   SG  GG  FP + +G  LG            + A   +  V 
Sbjct: 314 SLLILFAAKFLFSLICFGSGAPGGIFFPLLVLGALLGGAYSTFAVQYMGLDASYISNMVL 373

Query: 354 CAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAG 400
            A+ G    + R     + +   +    + +  + +V + A+L+ + 
Sbjct: 374 LAMAGYFTAIVRAPITGIILIFEMTGQVSQMLSMSLVSIVAYLVASA 420


>UniRef50_C5BP50 Chloride transporter, ClC family n=1 Tax=Teredinibacter turnerae
           T7901 RepID=C5BP50_TERTT
          Length = 608

 Score =  106 bits (263), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 70/393 (17%), Positives = 136/393 (34%), Gaps = 22/393 (5%)

Query: 11  LLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAV 70
            L++  + +G+ +  +++V   +     +      P            II    +  +A+
Sbjct: 43  QLTILGLIVGLFTGGVIVVFRLLTEQPLSYFMAGQPDNFESFSPRDRVIIIFSGILALAL 102

Query: 71  GLVI---RFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVN 127
            L +   ++ +   G            +P           ++ L  G S+G E P + + 
Sbjct: 103 VLKLAGKKYRETSVGHVLDRTHNHQGKLPLGNCVVQFAGAVVALVSGQSVGREGPAVHLG 162

Query: 128 IALAVAIGARLLPRVNRMEWTI-LASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRL 186
              A  +G  L    N M   +    A  I A F TP+A  +   + +     +      
Sbjct: 163 AGAASQLGQWLRLPSNSMHTLVGCGVAAAIAASFDTPMAGVIFAMEVIMMEYTI---VGF 219

Query: 187 FAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPR 246
              ++A+  G   +   F  H  L     G  +MT +L    +    +   + A   +  
Sbjct: 220 VPVILASVMGTAVSQAVFGKHSLL----VGSSDMTSLLELPYMVFFGLLIALCAAVYIRL 275

Query: 247 LHAMMHQMKNPV-LVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLA 305
               +   K PV L L   GF   ++ +   P  +  G D +   +A +  +     ++A
Sbjct: 276 NIFALQFGKYPVFLRLFAAGFYTAVIAIFV-PEIMGLGYDTVNAALAGK-LTVYSLLIIA 333

Query: 306 VIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPA------VPAAITVSCAILGI 359
             KLA   V    G  GG I P +F+G  +G ++   +P         A+      + G+
Sbjct: 334 AAKLAVTPVVIGLGVPGGVIGPLMFIGACVGGVVGTLLPLLVPEQQTNASFYAVLGMAGM 393

Query: 360 VLVVTRDGWLSLFMAAVVV--PNTTLLPLLCIV 390
           +         +L     +   P+     +L IV
Sbjct: 394 MAATLNAPLAALVAVLELSYNPHMIFPAMLVIV 426


>UniRef50_C3WBQ0 Chloride channel protein n=1 Tax=Fusobacterium mortiferum ATCC 9817
           RepID=C3WBQ0_FUSMR
          Length = 522

 Score =  106 bits (263), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 63/423 (14%), Positives = 134/423 (31%), Gaps = 24/423 (5%)

Query: 12  LSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVG 71
           L L  + +G  +  I+ +     +   +     +  +L     +  +I     L G+ V 
Sbjct: 20  LYLLCIIVGALTGFIVSLYRWALNYANHFREFIVKNSLSEGTLTIFFIWISFILIGLIVD 79

Query: 72  LVIRFSQGHAGP-DPACEPLIGAPVPP----SALPGLIVALILGLAGGVSLGPEHPIMTV 126
            + +     +G   P  + ++   +        L    +A ++ +  G+SLG E P + +
Sbjct: 80  YISKKYPKISGSGIPQVKGILLRKLDYVNWLQELIAKFIAGLMSIGAGLSLGREGPSVQL 139

Query: 127 NIALAVAIGARLLPRV-NRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDR 185
              +   I          +       S+  +   FG P++  +   + L+      L   
Sbjct: 140 GSYIGFGITKIFKKDSIEKKYLVTSGSSAGLAGAFGAPLSGVMFALEELHKYISAKL--- 196

Query: 186 LFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLP 245
           L    +A+ A        F    S  +       +       +   + I           
Sbjct: 197 LICTFLASIASDFVGRRMFGMETSFNLIANYPKNINPYYQFILYIILGIVIAFFGKLFTL 256

Query: 246 RLHAMMHQMKNPVLVLGI-GGFILG--ILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYF 302
            L  +  + K   +   I   F++   +L     P     G + +++M      +     
Sbjct: 257 TLIKVQDKFKELKISRWIKISFVMSTSLLFCYFLPEVTGGGHELVEEMAGGNR-TIQLLI 315

Query: 303 LLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEH------VPAVPAAITVSCAI 356
           ++ + KL    +  A+GF GG   P + +G  +G +          V        +   +
Sbjct: 316 IIFLAKLFFTALCYATGFAGGIFLPMLVLGAIIGKIYGLTLIKYLGVGLDFVPHFMVLGM 375

Query: 357 LGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAW-----LLLAGKPMMMVNRPKQ 411
            G  + V R       +   +  N   L  L  V + A+     L L     ++  R  +
Sbjct: 376 AGYFVAVVRAPITGAVLILEMTGNFDHLLALVTVSVVAYYVTELLGLEPIYEILFKRMPK 435

Query: 412 QPP 414
             P
Sbjct: 436 DTP 438


>UniRef50_A3DHF3 Cl-channel, voltage gated n=5 Tax=Clostridium RepID=A3DHF3_CLOTH
          Length = 435

 Score =  106 bits (263), Expect = 3e-21,   Method: Composition-based stats.
 Identities = 62/410 (15%), Positives = 135/410 (32%), Gaps = 24/410 (5%)

Query: 7   RTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLT 66
           R   ++ + A+ +G  +  I  V       + +              +  L+++  L + 
Sbjct: 12  RNQFIMCIAAIPLGAVTGAICAVFGLTLLKITDY-----------RTNHYLYLLPFLGIA 60

Query: 67  GIAVGLVIRFSQGHAGPDPACEPLIG----APVPPSALPGLIVALILGLAGGVSLGPEHP 122
           G+ +          +    A    I     + +P   +P  + +  L    G S G E  
Sbjct: 61  GVFITWCYNRFGNDSAKGMALLFEIHQDKRSSIPLRLIPFAVGSTWLTHLFGGSAGREGV 120

Query: 123 IMTVNIALAVAIGARLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPL 182
              +   L   IG ++          I   A     LF TP+AA     + L+       
Sbjct: 121 ATQIGGTLGSYIGNKIRVSGANKILMISGMAAGFSGLFHTPLAAVFFALEVLH------C 174

Query: 183 WDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAI-VAAIAIAAGMVAV 241
               ++ L+ +   A T              ++    +    S  + +  + +  G+  +
Sbjct: 175 GVIEYSALLPSFVSAYTASCISEILGLQKSTYFLDCRIVPSFSFIMKIIVLGVLFGLTGM 234

Query: 242 WCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDY 301
                L  +   + N +    I  F+ G +  I   +            + +  FS    
Sbjct: 235 LFSILLKKLRALLTNYIKNNIIRIFVFGTIIGIISIICFQGRYSGPGTNLISACFSNDIM 294

Query: 302 FLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVL 361
               ++K+    +  A+G+ GG + P   +G + G +L   +  +P  + V+     +  
Sbjct: 295 PWDFMLKILFTALTLAAGYYGGEVVPLFSIGASAGFVLANVL-GLPIELCVALGYAAVFG 353

Query: 362 VVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNRPKQ 411
             T   +  LF++   +  T  LP+   V   A++      +  +  P +
Sbjct: 354 SATNTFFAPLFIS-TEIFGTEYLPVFAAVCAIAYMFNGNNSIYPLQIPHE 402


>UniRef50_A6BDR3 Putative uncharacterized protein n=1 Tax=Dorea longicatena DSM
           13814 RepID=A6BDR3_9FIRM
          Length = 434

 Score =  105 bits (262), Expect = 3e-21,   Method: Composition-based stats.
 Identities = 66/374 (17%), Positives = 125/374 (33%), Gaps = 19/374 (5%)

Query: 49  LGIAQDSPLWIIGVLTLTGIAVGLVIRFSQGHAGPDPACEPLIG----APVPPSALPGLI 104
             I      ++I  L L G+ +  +                 +G      +P   +P  +
Sbjct: 45  TAIRTKYFWYLIWFLPLGGVFIWFIYHQFGKSVANGMKMVFHVGLGKNTKLPIRMVPLSV 104

Query: 105 VALILGLAGGVSLGPEHPIMTVNIALAVAIGARLLPRVN----RMEWTILASAGTIGALF 160
           +        G S G E   + +  A++  IG  +   ++    R  + I   A     LF
Sbjct: 105 IGTWTTHLFGGSAGREGVAVQIGAAVSNNIGRLVDKTIDIENSRKMFLITGMAAGFSGLF 164

Query: 161 GTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPI-----AHY 215
            TP+AA     + L        +  L    +A+ + A T+       F + I      H 
Sbjct: 165 CTPLAAIFFALEVLVAGKLE--YHALIPATVASISAAFTSRALGLRKFHINILETLNYHP 222

Query: 216 GQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLH-AMMHQMKNPVLVLGIGGFILGILGVI 274
                  +L  A +  +    G +    L  L      +  +PV  + I G ++ IL +I
Sbjct: 223 STYNAVLLLKLAAMGLVFGIVGSLFALILRYLRLKFAFRFSSPVKKVLIMGSVVAILMMI 282

Query: 275 GGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVA 334
                 + G       +     +   Y    ++K+A  ++  +SGF GG + P   +G  
Sbjct: 283 FH-QGRYSGTGSNLVALCFDGITDDIYAYDWILKMALTILTLSSGFIGGEVAPLFSIGSC 341

Query: 335 LGLMLHEHVPAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPA 394
           LG +L       P  +  +      V     +  L+  +  V      +LP   +V   +
Sbjct: 342 LGYVLGPVFGFDP--MFGAALGFASVFCSGSNTLLAAILVGVESFGYNMLPFFSVVCFVS 399

Query: 395 WLLLAGKPMMMVNR 408
           ++      +    R
Sbjct: 400 FIFNFNNSIFTAQR 413


>UniRef50_C5EV85 Chloride ion channel protein n=6 Tax=Clostridiales
           RepID=C5EV85_9FIRM
          Length = 526

 Score =  105 bits (262), Expect = 3e-21,   Method: Composition-based stats.
 Identities = 71/398 (17%), Positives = 142/398 (35%), Gaps = 17/398 (4%)

Query: 11  LLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAV 70
            L L  VA+G  +  +++    +      LL   L          P+W + ++    +  
Sbjct: 21  ELILEGVAVGAIAGAVVVAFRYLIGYADTLLNAILDYGKANTWFIPVWFLILVAAAFVVA 80

Query: 71  GLVIRFSQGHAGPDPACEPLIGAPVP---PSALPGLIVALILGLAGGVSLGPEHPIMTVN 127
           GL+   S       P  E  I   +       L   +   IL L  G+SLG E P + + 
Sbjct: 81  GLLKWESLISGSGIPQVEGEIIGEIDECWWRVLLAKLGGGILSLGCGLSLGREGPSIQLG 140

Query: 128 IALAVAIGARLLP-RVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRL 186
              A          R          ++  + A F  P+A  L   + ++      L    
Sbjct: 141 AMAAKGFSRLTKRVRTEEKLLITCGASAGLSAAFNAPIAGILFSLEEVHKHISPELLLSS 200

Query: 187 FAPLMAA-AAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLP 245
            A  + +        GL   P F+  I H   +         ++  +  A G+V    L 
Sbjct: 201 MAASITSDFVSRNVFGL--KPVFTFTITHMMPLNT--YGHVLLLGVLIGAMGVVYNTVLS 256

Query: 246 RLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLA 305
           ++  +  ++   ++ + I   + G+ G +   V    G   + + ++   F      LL 
Sbjct: 257 KIQDLYERIPWRLVRVLIPFLLAGVFGFLYRGVL--GGGHALVEEMSAGDFVLGSLCLLL 314

Query: 306 VIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAIT------VSCAILGI 359
           V+K    +V+  SG  GG   P + +G  +G + +     +  +++      +   + G 
Sbjct: 315 VVKFCFSMVSFGSGAPGGIFLPLLVLGAIIGSIYYRLAEPLSPSLSGLLVNFIILGMAGY 374

Query: 360 VLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLL 397
              + R     + + + +  + + L  L +V L A+L+
Sbjct: 375 FSAIVRAPITGIILISEMSGSFSHLLTLSMVSLAAYLV 412


>UniRef50_A4YDN2 Cl-channel, voltage-gated family protein n=19 Tax=cellular
           organisms RepID=A4YDN2_METS5
          Length = 588

 Score =  105 bits (262), Expect = 3e-21,   Method: Composition-based stats.
 Identities = 81/438 (18%), Positives = 153/438 (34%), Gaps = 41/438 (9%)

Query: 14  LPAVAIGIASSLILIVVMKIASVLQNLLWQRLPG-------------TLGIAQDSPLWII 60
           +  + +G+ +     V   +  V + +   R  G                    + + + 
Sbjct: 16  ILGILLGVVAGFASTVFYLLLHVFEYIFITRFVGMSYPHPLGEGGTLNFTFHPGNFILVP 75

Query: 61  GVLTLTGIAVGLVI-RFSQGHAGP--DPACEPLI--GAPVPPSALPGLIVALILGLAGGV 115
             L + G+  GLV+  F+    G   D A +        V    +P  I A  + +  G 
Sbjct: 76  VSLMIGGLISGLVVYTFAPEAEGHGTDAAIKAYHYLQGKVRWVVIPVKIFASAVTIGSGG 135

Query: 116 SLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTL 174
           S G E P    +  +   I   L L   +R     +     IG +F TP+  AL+ S+ L
Sbjct: 136 SAGREGPTAQFSSGVGSVIADLLKLSPEDRRRALAVGIGAGIGTIFKTPIGGALLASEIL 195

Query: 175 NGSSEVPLWDRLFAPLMAAAAGALTTGLFFH--PHFSLPIAHYGQMEMTDILSGAIVAAI 232
                 P  + ++  L+A++ G    G+ F   P F      +  M +      A++  I
Sbjct: 196 YKRDLEP--ELIYPGLIASSVGYTIFGIIFGFTPVFGYYTGTFNPMRLPLY---ALLGVI 250

Query: 233 AIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQ---- 288
           +    ++ V     +  +  ++K P  V  + G  L  L  +  P  +  G   +     
Sbjct: 251 SGLLAILYVKSFYGISGLFKRLKLPNHVKPMIGGGLAGLLTLLFPEVMGTGYGWINLAEF 310

Query: 289 ----QMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLM----LH 340
                  +          LL ++K+ A  ++  SG  GG   P +F+G  LG       H
Sbjct: 311 ERFSSFYSPVLPVLLLLALLPLVKILATSLSIGSGGSGGVFAPGLFIGAFLGADVGLIFH 370

Query: 341 EHVPAVPAAIT--VSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL 398
              P++   I   V   ++       +     + M   +  +  LLP   I +  ++L+ 
Sbjct: 371 YLFPSLVPNIAPFVIIGMMSFFAAAGKVPLSVIVMVTEMTSSLQLLPGAMIAVAISYLVS 430

Query: 399 AGKPMMMVNRP-KQQPPH 415
               +     P ++  P 
Sbjct: 431 GNYTIYRSQVPTRRDSPA 448


>UniRef50_D0MHJ3 Chloride channel core n=1 Tax=Rhodothermus marinus DSM 4252
           RepID=D0MHJ3_RHOM4
          Length = 625

 Score =  105 bits (261), Expect = 4e-21,   Method: Composition-based stats.
 Identities = 70/432 (16%), Positives = 130/432 (30%), Gaps = 34/432 (7%)

Query: 15  PAVAIGIASSLILIVVMKIASVLQNLLWQRLPG-----------------TLGIAQDSPL 57
            +  IG+  +L  +V  ++ ++L  L+     G                    +      
Sbjct: 39  YSAIIGVLGALAALVFGELVTLLTRLILIEGAGYPVPFPRGEGGTDIFDLEQVLHPARRW 98

Query: 58  WIIGVLTLTGIAVG-LVIRFSQGHAGPDPACEPLIGAP----VPPSALPGLIVALILGLA 112
            ++    + G+  G +V  F+    G                +   A    IVA  L + 
Sbjct: 99  LLLIAPAVGGLLAGWIVFTFAPEAEGHGTDSVIRAFHRERGFMRLRAGLVKIVAAALTIG 158

Query: 113 GGVSLGPEHPIMTVNIALAVAIGA-RLLPRVNRMEWTILASAGTIGALFGTPVAAALIFS 171
            G S G E PI  +   L   +     L    R  + +   A  + ++F +P+  A    
Sbjct: 159 SGGSAGREGPITQIGATLGSWLAQRLRLSERERRLFLVAGMAAGLSSIFRSPLGGAFFAV 218

Query: 172 QTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAA 231
           + L    E    + L   ++A+  G                  +  +   ++L     A 
Sbjct: 219 EVL--YREDIESEALMPAIVASITGYSLYTSIERSGTVFVTPRFEFVSPLELLPLIGFAL 276

Query: 232 IAIAAGMVAVWCL-PRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQM 290
                G+  V         +   +  P  +    G +L        P  +      +QQ 
Sbjct: 277 CCAIVGIFYVRVFYGTKRRIFDPLPLPPALKPALGGLLVGAIAFFFPAIMGSSYGWLQQA 336

Query: 291 VANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVAL----GLMLHEHVP-- 344
           +           LLA++K+ A  +   SG  GG   P++ +G  L    G  LH   P  
Sbjct: 337 IDGN-LPLGFMALLALLKIFATSLTIGSGGAGGTFAPSLVIGGMLGGLYGEGLHRLFPTL 395

Query: 345 AVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMM 404
                  V   +   V         +  M + +  + +LL  L    +   L+     + 
Sbjct: 396 ITQPEAYVLIGMGTFVGGAANVPIAATIMISEMTGSYSLLVPLIFAGVITHLVARRWSLF 455

Query: 405 MVN-RPKQQPPH 415
               R     P 
Sbjct: 456 EEQVRTHNDSPA 467


>UniRef50_A2ZX03 Putative uncharacterized protein n=2 Tax=Oryza sativa
           RepID=A2ZX03_ORYSJ
          Length = 718

 Score =  105 bits (261), Expect = 4e-21,   Method: Composition-based stats.
 Identities = 74/441 (16%), Positives = 153/441 (34%), Gaps = 41/441 (9%)

Query: 11  LLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLP--GTLGIAQDS----PLWIIGVLT 64
           L++L A  +G+ S + +++       +++L W  +P  G   + ++S       +I V  
Sbjct: 79  LVTLAACLVGLLSGVSVVLFNLSVHEIRDLFWDGIPLRGASWLREESIGEIWQRVILVPV 138

Query: 65  LTGIAVGLVIRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIM 124
             GI VG+        A         I     P       +A    L  G SLGPE P +
Sbjct: 139 SGGIIVGVFNTLRSSIATNSNDTMSKIKGAFRP---FLKAMAASFTLGTGNSLGPEGPSV 195

Query: 125 TVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTL---NGSSEV 180
            +  ++A   G    L    ++      SA  I + F   VA      +++         
Sbjct: 196 EIGSSIAKGFGNVFKLEGGKKLSLVAAGSAAGIASGFNAAVAGCFFAVESVLWPTSVDSS 255

Query: 181 PLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVA 240
            L +     +++A   ++ + +      +  +  Y     T++    ++           
Sbjct: 256 SLSNSTPMVILSAVIASVVSEIGLGSDPAFTVPEYDFRSPTELPLYLLLGIFCGLVSTTL 315

Query: 241 VWCLPRLHAMMHQMKN-----PVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMV---- 291
             C      ++  ++            +GG I+G+L ++  P  L+ G + +  ++    
Sbjct: 316 SRCTALSMEIVQSLQTATGLPKAASPALGGLIVGLLALVY-PEVLYWGFENVDILLESRP 374

Query: 292 ANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHE---------- 341
                S +    L  +K+ A  +  A G  GG   P++F+G A G+   +          
Sbjct: 375 FTSGLSAAVLVQLIGVKVLATSLCRAFGLVGGYYAPSLFIGAATGMAYGKVMRFTFTGPD 434

Query: 342 ------HVPAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTL-LPLLCIVMLPA 394
                  +            +   +  V +    S+ +   +  +  + LPLL  V + +
Sbjct: 435 SLFQIPFLDVASPQAYGLVGMAATLAGVCKVPLTSVLLLFELTQDYRIVLPLLGAVGVSS 494

Query: 395 WLLLAGKPMMMVNRPKQQPPH 415
           W+  + +     NR K     
Sbjct: 495 WI-ASPQRFSRSNRSKPDSSE 514


>UniRef50_C1SJ13 Chloride channel protein EriC n=1 Tax=Denitrovibrio acetiphilus DSM
           12809 RepID=C1SJ13_9BACT
          Length = 440

 Score =  104 bits (260), Expect = 5e-21,   Method: Composition-based stats.
 Identities = 69/398 (17%), Positives = 147/398 (36%), Gaps = 17/398 (4%)

Query: 12  LSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTL--GIAQDSPLWIIGVLTLTGIA 69
           + L AV +G  +    I+   + S  QNL +      +   +       II V  + G+ 
Sbjct: 1   MVLIAVIVGACAGFGNIIFRYLISFFQNLFYGTKSEYVLEALNNTPFYKIILVPAIGGLM 60

Query: 70  VGLV---IRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTV 126
           VG +    +F++GH  PD      +   + P      + +  + L  G S G E PI+ +
Sbjct: 61  VGGISIMFKFAKGHGVPDVMKAIALNRSISPLIAVIKVFSSAITLGSGGSAGREGPIVQI 120

Query: 127 NIALAVAIGARLLPRVNRMEWTILASAGTIGAL-FGTPVAAALIFSQTLNGSSEVPLWDR 185
             A+   IG        RM+  I   A    A  F  P+  A+  ++ L G   +     
Sbjct: 121 GAAIGSGIGKVFSFSSARMKTVIACGAAGGLAATFNAPIGGAMFAAEVLLGEFGL---KT 177

Query: 186 LFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLP 245
               ++++    + +  +   H +     Y    + ++    ++  +    G++ +    
Sbjct: 178 FSPIIISSVIATVVSRAYLGDHVTFDAPEYVLHSIFELPLYTLLGMLCAVIGIIFIRVYY 237

Query: 246 RLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLA 305
           +      ++  P       G +L     +     +  G D +  ++++ A       LL 
Sbjct: 238 KFEEKFEELTIPSWSKPALGGLLMGCVALLSRDVMGVGYDTIDSILSHNA--GFMLILLV 295

Query: 306 VIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAIT------VSCAILGI 359
            +K+ A  +   SG  GG   P++++G A G      V  +   +T         A+  +
Sbjct: 296 FLKIIATSLTLGSGGSGGLFVPSLYIGAATGGFFGWIVNLLFPTMTGGSGAYGLVAMSAM 355

Query: 360 VLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLL 397
           +    R    ++ +   +  + T++  L +  + A + 
Sbjct: 356 LAATIRAPLTAILIIFEITQSYTVILPLMLTAIVANIF 393


>UniRef50_A3HUV6 Putative transport related, membrane protein n=1 Tax=Algoriphagus
           sp. PR1 RepID=A3HUV6_9SPHI
          Length = 564

 Score =  104 bits (260), Expect = 5e-21,   Method: Composition-based stats.
 Identities = 67/408 (16%), Positives = 145/408 (35%), Gaps = 32/408 (7%)

Query: 18  AIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRFS 77
            IG+ S L  +++      +QN L +             L+ +  +T   +    + +  
Sbjct: 2   IIGVLSGLAAVLLKGAVHAIQNFLTEDFYNEYA-NFLYILYPMIGITAAYLVGKFIFKDV 60

Query: 78  QGHAGPDPACEPLIGAPVPPS-ALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGA 136
            GH  PD          + P   +   +    L +  G S+G E P++    A+    G 
Sbjct: 61  GGHGIPDVLFIISKKQSLIPRVKMYSRLFTSALTVGFGGSVGLEAPMVVTGSAIGSNTGL 120

Query: 137 RLLPRVNRMEWTI-LASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAA 195
            +     +    I   +A +I A+FG P+ A +   + +     +         L+A+  
Sbjct: 121 LMHLNGKKRALLIGCGAAASISAIFGAPIGAVIFAIEVVLLEVSIA---SFIPLLIASVT 177

Query: 196 GALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMK 255
           G+LT+ +                    +     +  I     +     + +   ++  ++
Sbjct: 178 GSLTSMILIGKESIFNFRFEETFLAAHMPYYLGLGIICGLVSLYFNRAVRKTELVLEGLE 237

Query: 256 NPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQA---FSTSDYFLL-------- 304
           +  + +  GG +LG + V   P    +G + + Q++  ++    + S +F +        
Sbjct: 238 SQTIRMLYGGALLGFM-VFFFPPIYGEGYNTLNQLIDGKSAEILNRSPFFSVIENPYMII 296

Query: 305 ------AVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHE-------HVPAVPAAIT 351
                  ++K  A  +    G  GG   P+++VG  +G +          H+P  P A  
Sbjct: 297 IFLILIILVKPIASALTIGGGGSGGIFAPSLYVGGIVGFVFAYSKNLLGFHIPL-PLASF 355

Query: 352 VSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLA 399
              A+ G++  V      ++F+ A +     L   L  V   +++   
Sbjct: 356 TLVAMCGVMSGVQHSPLSAIFLIAEITGGYELFVPLMFVSAISYITTT 403


>UniRef50_Q020M6 Cl-channel, voltage-gated family protein n=2 Tax=Acidobacteria
           RepID=Q020M6_SOLUE
          Length = 874

 Score =  104 bits (260), Expect = 5e-21,   Method: Composition-based stats.
 Identities = 83/377 (22%), Positives = 151/377 (40%), Gaps = 25/377 (6%)

Query: 40  LLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLV-IRFSQGHAGP-DPACEP---LIGAP 94
           LL +RL   L     +    + +  +   A GL+  R+     G   P  +    L    
Sbjct: 7   LLTERLGSRLYPPGGTAWRRLVIPLVGSFATGLLMFRYFPDARGSGIPQTKVALFLRDGY 66

Query: 95  VPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARLLPR-VNRMEWTILASA 153
           +    + G      + LA G++LG E P + V+  +A  +G RL     +      + ++
Sbjct: 67  ISLRTVLGKFGLCSVSLASGIALGREGPSVQVSAGIASVLGRRLGLGPSSVRALIPIGAS 126

Query: 154 GTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIA 213
             + A F TP+AA L   + + G    P+   L + ++++A   +   L        P+ 
Sbjct: 127 AALAAAFNTPIAAVLFSLEEVMGDMHAPV---LGSIVLSSATSWIVLHLVLGDE---PLF 180

Query: 214 HYGQMEMTDILSGAIVAAIAIAAGMVAVWCL-----PRLHAMMHQMKNPVLVLGIGGFIL 268
           H    ++   L   I A + +A G+V+V  +      R H +    +   L   IGG  +
Sbjct: 181 HVPSYQLVHPLEFGIYALLGVAGGLVSVGFVKLLLWQRKHFLSLPARTRWLQPTIGGLTV 240

Query: 269 GILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPA 328
           GILG    P  L  G   + Q +  Q    +   L+ + K+ A     ASG  GG   P+
Sbjct: 241 GILG-WYFPAVLGVGYGFVGQALNGQMLIGAMALLVCL-KIVATSTCYASGNAGGIFGPS 298

Query: 329 VFV----GVALGLMLHEHVPAVPAAITVSCA--ILGIVLVVTRDGWLSLFMAAVVVPNTT 382
           +F+    G A+G + H+ +P    +        +      + R    S+ M   +  + T
Sbjct: 299 LFIGAMMGGAVGGVAHQLLPDYTGSAGAYALVGMGAAFAGIIRVPLTSVIMIFEITRDYT 358

Query: 383 LLPLLCIVMLPAWLLLA 399
           ++  L I  L ++ + +
Sbjct: 359 IIVPLMISNLASYWISS 375


>UniRef50_D1W6U8 Chloride transporter, ClC family n=16 Tax=Bacteroidales
           RepID=D1W6U8_9BACT
          Length = 595

 Score =  104 bits (260), Expect = 6e-21,   Method: Composition-based stats.
 Identities = 62/417 (14%), Positives = 137/417 (32%), Gaps = 40/417 (9%)

Query: 14  LPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGI-AVGL 72
           + A  IGI +S+   V+  I   +Q+LL      T G    +  W+  +  + GI    L
Sbjct: 26  ILAFFIGIFASVAAYVLHFIIRQIQHLL------TAGFDATTYNWLYLLFPVIGIYITSL 79

Query: 73  VIRFSQGHAGPDPACEPLIG-----APVPPSALPGLIVALILGLAGGVSLGPEHPIMTVN 127
            +R+           + L       + +        +++  + +  G S+G E PI+   
Sbjct: 80  FVRYVVKDNISHGITQVLYAISTKQSRLKAHNCWTSVISSAITIGFGGSVGAEAPIVLTG 139

Query: 128 IALAVAIGARLLPRVNRMEWTI-LASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRL 186
            A+   +G         +   +   ++  I  +F  P+A  +   + L     +     L
Sbjct: 140 SAIGSNLGQLFKMDNKTLMLLVGCGASAAIAGIFKAPIAGLVFTLEVLMVDLSMA---SL 196

Query: 187 FAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPR 246
              L +     + T +F                +  I +  ++        +  +  + +
Sbjct: 197 LPILTSTVTATVFTYIFVGNRSLFDFTLDSAWNIDRIPASILLGLFCGMVSLYFIRMMSK 256

Query: 247 LHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQA----------- 295
              +  Q+K+        G IL    +   P    +G + +  ++               
Sbjct: 257 CEGVFEQLKDYPFAKLFLGAILLSSLIFFFPSLYGEGYNSLNILLNGNTEADWNAVMNNS 316

Query: 296 -------FSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPA--- 345
                         L+ + K+ A      +G  GG   P++FVG   G +          
Sbjct: 317 LFAGSSGLLVIYIALVLLTKIFATSATNGAGGVGGTFAPSLFVGGFGGFLFARVWNMNQV 376

Query: 346 ---VPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLA 399
              +P        + G++  V       +F+ A +    +L   L +V + + ++++
Sbjct: 377 GTYIPEKNFTLLGMAGVMAGVMHAPLTGVFLIAELTGGYSLFLPLIMVSIVSVMVIS 433


>UniRef50_C7NEM7 Chloride channel core n=3 Tax=Leptotrichia RepID=C7NEM7_LEPBD
          Length = 560

 Score =  104 bits (259), Expect = 7e-21,   Method: Composition-based stats.
 Identities = 71/409 (17%), Positives = 135/409 (33%), Gaps = 27/409 (6%)

Query: 7   RTMLLLSLPAVAIGIASSLIL---IVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVL 63
           R  ++L      +GI S +I+    +++K  S+ +         T  +     +  I V 
Sbjct: 19  RNNIVLIFLCFLVGIFSGIIVGTYTLLLKKMSIFREFF------TTNLELPKIIIGIIVF 72

Query: 64  TLTGIAVGLVIRFSQGHAGP-DPACEPLIGAPVPPS---ALPGLIVALILGLAGGVSLGP 119
            L G+AV  ++      +G   P    L+   V       L    V  IL +  G+S+G 
Sbjct: 73  ILMGMAVQFMLSKYPLISGSGIPQVSGLLTKKVKFKWFGELVTKFVGGILAIGTGMSMGR 132

Query: 120 EHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSS 178
           E P + +   +   I        V         ++  I + F  P+A  +IFS       
Sbjct: 133 EGPSVHLGALVGSGIKEVTKRSEVEEKYLVTCGASAGISSTFNAPLAG-VIFSLEELHKF 191

Query: 179 EVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAA-- 236
             PL   L   L+A+      + +    H S         ++   +   I     I    
Sbjct: 192 FSPLL--LICTLVASGTSNFISRMILGSHTSFQYNFMLPKDIPYYIFAIITVIFCIIITI 249

Query: 237 -GMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQA 295
            G    + L  +     + K    V  +   I+     +        G + +++M     
Sbjct: 250 TGKAFSYFLLLIQRQYKKWKLNKYVKMLLFMIIAYAIAVFFSDITGGGHELIEEMFGKNV 309

Query: 296 FSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEH------VPAVPAA 349
                  ++ V+K    ++  A+G  GG   P + +G   G +  E       +P     
Sbjct: 310 LL-RTLIIILVLKFFYTMLCYATGAPGGIFLPMLVIGALTGKVYGEILNHYFSIPNEIIV 368

Query: 350 ITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL 398
             +   +      V R     + +   +  N + L +L IV    ++  
Sbjct: 369 HFMLLGMAAYFTAVVRAPITGITLILEMTGNFSYLYMLIIVCTITYIFT 417


>UniRef50_Q21MI5 Cl-channel, voltage gated n=1 Tax=Saccharophagus degradans 2-40
           RepID=Q21MI5_SACD2
          Length = 585

 Score =  104 bits (259), Expect = 7e-21,   Method: Composition-based stats.
 Identities = 72/389 (18%), Positives = 136/389 (34%), Gaps = 17/389 (4%)

Query: 22  ASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVI---RFSQ 78
            + +I+++   +  +  +      P          +W++ +     IA+ L     + SQ
Sbjct: 36  FTGVIIVIFRLLIDLPLSYFLDTRPDNFEAMPTDMIWLLIMGGTIPIAILLHFAGKKRSQ 95

Query: 79  GHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARL 138
                           +P S          L +  G S+G E P + +   +A  +G  L
Sbjct: 96  TGVSHVIDRLHNYQGQLPTSNWMVQFFGAALCMLSGQSVGREGPAVHLGAGVASKLGKWL 155

Query: 139 -LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGA 197
            LP  + +       A  I A F TP+A  +   + +     V         ++A+  G 
Sbjct: 156 NLPNNSLLTLIACGVAAGISASFDTPMAGVIFAMEVVVLEYTV---VGFVPVILASVMGT 212

Query: 198 LTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNP 257
           + + L F    +  I   G ++M  +L    +  + +A  + A   +      M   K P
Sbjct: 213 MVSQLVFGEASNFKI---GPVDMGSLLELPYMIVMGLAISVCAAAYIKLNLGAMRLSKYP 269

Query: 258 VLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAA 317
           V +  I   +L      G P  +  G D +  ++  +    S   ++ V KL    V   
Sbjct: 270 VALRVIVAGLLTATIASGVPEVMGLGYDTVNAIIVGEVLLFS-LLIIGVAKLFLTPVVIG 328

Query: 318 SGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAIT------VSCAILGIVLVVTRDGWLSL 371
            G  GG I P + VG  LG +L     AV   +       V   + G++         +L
Sbjct: 329 LGMPGGVIGPLLVVGACLGGVLGTFFDAVFPNLGASPGFYVVLGMAGMMAATLNAPLAAL 388

Query: 372 FMAAVVVPNTTLLPLLCIVMLPAWLLLAG 400
                +  N  ++    +V++ + L    
Sbjct: 389 VAVLELSYNPNMIFPAMLVIVVSCLSTRQ 417


>UniRef50_A5EFE0 CLC-type chloride channel protein n=3 Tax=Bradyrhizobium
           RepID=A5EFE0_BRASB
          Length = 595

 Score =  104 bits (259), Expect = 7e-21,   Method: Composition-based stats.
 Identities = 78/365 (21%), Positives = 150/365 (41%), Gaps = 15/365 (4%)

Query: 8   TMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVL---T 64
               L   A+ IG+A+  I+ V M + + + ++L   +P  + ++ ++ +  I  L    
Sbjct: 28  NEFYLIPLALVIGVATGAIVTV-MSLIAQVAHVLIYGIPIDVRLSANAWVNPIIALIAPA 86

Query: 65  LTGIAVGL---VIRFSQGHAGPDP-ACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPE 120
             G+ +G+   + R  +  A  DP     L G  +       +    ++    G S+G E
Sbjct: 87  CGGLILGVMEWLRRRWKIAAAVDPVEANALRGGRLSMRDSIVVSSQTLVSNGSGASVGLE 146

Query: 121 HPIMTVNIALAVAIGARLLPRVNRMEWTILASAGTIGALFGT-PVAAALIFSQTLNGSSE 179
                +   +A  +G  L  R N +   +   A    A     P+  A    + + G   
Sbjct: 147 AGYTQIGAGVASLLGQYLTLRRNDLRLIVGCGAAAAIAAAFGAPITGAFYACELIVGVYS 206

Query: 180 VPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMV 239
           V         L A+ AGALT+       +SL I   G +     ++  ++A +    G+V
Sbjct: 207 VA---SAAPILAASLAGALTSQYLTGAPYSLEIQKVGAVGFEQYIALFVLALLVAGIGIV 263

Query: 240 AVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTS 299
            +   P +  +  ++    L   IGG  +G + ++  P  L  G   M  +  ++  +  
Sbjct: 264 VMRASPAVERLFVRIPV-WLRPAIGGVCVGAMAIVT-PQVLAAGHGAM-LLDLHREMAVG 320

Query: 300 DYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGI 359
               + V+KLAA +++ ASGFRGG  F ++F+G  LG +    +  V   + +   +  +
Sbjct: 321 MIATIIVLKLAACLISLASGFRGGLFFASLFIGSLLGKLFAGLLAMVGLGVALDPLVAML 380

Query: 360 VLVVT 364
             + T
Sbjct: 381 TGMAT 385


>UniRef50_B5FF64 Chloride channel protein n=4 Tax=Bacteria RepID=B5FF64_VIBFM
          Length = 459

 Score =  104 bits (258), Expect = 8e-21,   Method: Composition-based stats.
 Identities = 81/426 (19%), Positives = 150/426 (35%), Gaps = 27/426 (6%)

Query: 1   MLHPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWII 60
           M HP  R    L   A      S LIL V + + S     LW  L      A+ +  W+I
Sbjct: 1   MAHPLNRNFQNLFQVAR----WSLLILPVTLLVGSFNAFFLW--LLSEATQARIANPWLI 54

Query: 61  GVLTLTGIAVGLVIR-FSQGHAGPDPACEPLI---GAPVPPSALPGLIVALILGLAGGVS 116
            +L + G+A+    R + +  AG +      I   G  VP    P ++   ++    G S
Sbjct: 55  YLLPVAGLAIVYSYRNWGKNSAGGNNLIMDEIHQAGEGVPVRMGPLVLFTTVITHLFGGS 114

Query: 117 LGPEHPIMTVNIALAVAIGARLLPRVNRMEWTI-LASAGTIGALFGTPVAAALIFSQ--T 173
            G E   + +  A    +        +  +  +    A    ++FGTP   A+   +   
Sbjct: 115 AGREGTAVQIGGATTDWLSKVFKLSEDDRKMMLTAGVAAGFASIFGTPFTGAIFALEVLF 174

Query: 174 LNGSSEVPLWDRLFAPLMAAAAGAL-----TTGLFFHPHFSLPIAHYGQMEMTDILSGAI 228
           +       +   L A ++A    +      T  L      S    H   +++  +    I
Sbjct: 175 IGRIKFNAIIPALLAAILANVVASAWGAHHTHYLINFDQVSTLFGHAVDIDLLLMAKVII 234

Query: 229 VAAIAIAAGMVAVWCLPRLHAMM-HQMKNPVLVLGIGGFILGILGVIGGPVS-----LFK 282
            A     AG +          +    +KNP L++ +GG ++ I+  + G        ++ 
Sbjct: 235 AAIGFGIAGYLFGELTHGFKDLFNATLKNPYLIVVVGGLMVIIITQLLGNYDYIGIGVYP 294

Query: 283 GLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEH 342
             D    + +      ++++   ++KL    +  A+G++GG + P  FVG  LG  L   
Sbjct: 295 SRDGGVSITSAFTEGGAEWYSW-ILKLVLTAITLAAGYKGGEVTPLFFVGATLGNFLGWV 353

Query: 343 VPAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKP 402
           +   P  +  +   L +    T        M   +   +  LP   +    A+       
Sbjct: 354 M-GAPVDLFAALGFLAVFAAATNTPLACTIMGVELF-GSEYLPYFALACYTAYYFSGHTG 411

Query: 403 MMMVNR 408
           +    R
Sbjct: 412 IYSSQR 417


>UniRef50_Q1GIU0 Cl-channel voltage gated n=37 Tax=Rhodobacterales
           RepID=Q1GIU0_SILST
          Length = 564

 Score =  104 bits (258), Expect = 8e-21,   Method: Composition-based stats.
 Identities = 61/353 (17%), Positives = 133/353 (37%), Gaps = 20/353 (5%)

Query: 5   RARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLW--QRLPGTLGIAQDSPLWIIGV 62
           R  + L   L A+ IG+ +    +   K  + LQ  ++  + +      A   P +++ +
Sbjct: 30  RGPSQLQFWLIALVIGVLAGFAALFFRKGITALQGAVYGAEDVDYLHSFAATLPWYVLLL 89

Query: 63  LTL-TGIAVGLVIRFSQGHA-----GPDPACEPLIGAPVPPSALPGLIVALILGLAGGVS 116
           + +  G+ VG+++                    L    V          A  L L+ G S
Sbjct: 90  VPVFGGLIVGIILHRFTPDGRVRSVADVIEGAALRDGRVEIREGLASACASFLTLSTGGS 149

Query: 117 LGPEHPIMTVNIALAVAIGARLLP-RVNRMEWTILASAGTIGALFGTPVAAALIFSQTLN 175
            G E P++ +   ++  +  R+    +   +    A A  + A F  P+A AL   + + 
Sbjct: 150 SGREGPVVHIAGMISTWVSDRIRADGITGRDLLGCAVAAAVSASFNAPIAGALFAMEVVL 209

Query: 176 GSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEM-TDILSGAIVAAIAI 234
               V  +      ++A+ AG +   L +       +   G ++   ++ +  ++  I  
Sbjct: 210 RHFSVNTFA---PIVVASVAGTVINRLEYGDVTEFVLTTPGALQFYVELPAFLMLGLICG 266

Query: 235 AAGMVAVWCLPRLHAMMHQMKNPV-----LVLGIGGFILGILGVIGGPVSLFKGLDEMQQ 289
              +V +  +     +   +++ +     L   + GF+LG++  I  P  +  G +    
Sbjct: 267 VVAVVLMHSIFLADRVGTAVQSALGMPRWLRPTVAGFLLGLVA-IWYPHIIGVGYETTVL 325

Query: 290 MVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEH 342
            ++  +   S   L  ++K+AA+ +       GG   P++ VG   GL     
Sbjct: 326 ALS-GSLLLSQAILFTIVKVAAVSITMGGRMGGGVFSPSLMVGALTGLAFGLI 377


>UniRef50_D2BKV3 Chloride channel protein n=4 Tax=Lactococcus lactis
           RepID=D2BKV3_LACLK
          Length = 512

 Score =  104 bits (258), Expect = 9e-21,   Method: Composition-based stats.
 Identities = 70/402 (17%), Positives = 144/402 (35%), Gaps = 24/402 (5%)

Query: 10  LLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIA 69
           L L   +V +G+ +  +  +        +                 PL I+G+  L  + 
Sbjct: 14  LYLLFLSVLVGLTAGFLASLYRLALEKAETWGLSIYRFVSSHIIFIPLLILGLAFLAFVV 73

Query: 70  VGLVIRFSQGHAGPDPACEPLIGAPVP---PSALPGLIVALILGLAGGVSLGPEHPIMTV 126
              + ++        P  +  +         +      +A  L +  G+SLG E P + +
Sbjct: 74  TFFMKKYPMSSGSGIPQVKGQLQGYFKNNWFTTAFAKFIAGTLAMFAGLSLGREGPSVQL 133

Query: 127 NIALAVAIGARLLPRVNRMEWTIL-ASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDR 185
             ++   + +RL          I   ++  + A F  P++  +   + +           
Sbjct: 134 GASMGQMVSSRLAETERHKRILIASGASAGLSAAFNAPLSGVMFTLEEVFKYFSP----- 188

Query: 186 LFAPLMAAAAGALTTGLFFHPHFSL-PIAHY---GQMEMTDILSGAIVAAIAIAAGMVAV 241
               L+     A+   +     F   P+ H+   G +E+++     I+  I    G    
Sbjct: 189 --LILLTCMTSAMVADMVARIMFGSGPVFHFQIVGSIELSNYWLLIILGIILGFFGAFYN 246

Query: 242 WCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDY 301
           W L     +M ++K+P L + +   ++G  G++  P  +  G   M         +    
Sbjct: 247 WTLLTSQNLMKKIKSPFLRVLLTFLVVGATGLL-FPNIIGSGHRLMDSFSLGMGLAFLCL 305

Query: 302 FLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHE------HVPAVPAAITVSCA 355
            L+   K    +V+ ASG  GG  FP + +G +LG +         H+P+   A  V  A
Sbjct: 306 ILIG--KYLISMVSYASGVPGGIFFPLLVLGASLGAVFATIVISLFHLPSHLFANLVILA 363

Query: 356 ILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLL 397
           + G    + R     + +   +  +   L  L +V L A+++
Sbjct: 364 MAGTFTAIVRAPMTGILLLVEMTGSFDHLLPLALVSLIAYVV 405


>UniRef50_B2UP88 Chloride channel core n=1 Tax=Akkermansia muciniphila ATCC BAA-835
           RepID=B2UP88_AKKM8
          Length = 596

 Score =  104 bits (258), Expect = 1e-20,   Method: Composition-based stats.
 Identities = 73/401 (18%), Positives = 147/401 (36%), Gaps = 22/401 (5%)

Query: 12  LSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTL-----GIAQDSPLW----IIGV 62
           + + AV +G   +L+ +V      ++Q++L  R           +A   P W        
Sbjct: 37  IFIWAVVVGALGALMALVFEMGVELVQDVLTGRTSYRQIQVFQEMANQDPAWCIFVPAAG 96

Query: 63  LTLTGIAVGLVIRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHP 122
             L G+ +    RF    A        L    VPP       ++ +  +  G S+G E P
Sbjct: 97  GLLAGLTLLFTHRFVPAKATEYMEAVALGNGYVPPKPSLLRSLSAVFSVGSGASIGREGP 156

Query: 123 IMTVNIALAVAIGARLLPRVNRMEWTI-LASAGTIGALFGTPVAAALIFSQTLNGSSEVP 181
           ++        A+G        R+   +  A+A  + + F TP+A  L  S+ + G+  + 
Sbjct: 157 LVQAAAVAGSALGRFFHLSAPRLRLVVACAAASGMSSAFHTPLAGGLFVSEIVLGALTID 216

Query: 182 LWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQM-EMTDILSGAIVAAIAIAAGMVA 240
               L   L+A+ AG  T GLF  P     +     +     +L   ++ A+A       
Sbjct: 217 F---LAPLLVASCAGYFTMGLFHEPAPIYQLQQEVSLAGNQHVLWCVLLGALASLVASFW 273

Query: 241 VWCLPRLHAMMHQMKNPV-LVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTS 299
           +  L +    ++  +  + + L   G ++G + +   P  +  G + +  ++ +  F  +
Sbjct: 274 LLILKKSRRYLNGKRQWLPVRLTAAGVLVGAIAIFY-PEIVGNGKNIITSLI-HYEFDAA 331

Query: 300 DYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEH-----VPAVPAAITVSC 354
              +L  +K+  + +    G  GG + P++ +G   G +         VP   A      
Sbjct: 332 RAAVLLFLKIFTVAIVFGVGTVGGALTPSLTIGSVCGFLFSAALTQLGVPGDHAIAYSLV 391

Query: 355 AILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAW 395
            +             SL +         ++  L I +L ++
Sbjct: 392 GMAAFFTTAANAPITSLVLVVEFTMAGQMMFPLIIGVLVSY 432


>UniRef50_Q1K0X2 Cl-channel, voltage gated n=1 Tax=Desulfuromonas acetoxidans DSM
           684 RepID=Q1K0X2_DESAC
          Length = 587

 Score =  103 bits (257), Expect = 1e-20,   Method: Composition-based stats.
 Identities = 65/390 (16%), Positives = 139/390 (35%), Gaps = 25/390 (6%)

Query: 12  LSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTL-TGIAV 70
           L L A  IG+ +  + +    +      L W      +      P +++  + +  G+ +
Sbjct: 25  LLLIAATIGVVTGTLAVAFRYLLLETTALFWGESYDLVAATAAMPWYLVVAIPVAGGLIL 84

Query: 71  GLVI-RFSQ----GHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMT 125
           G ++ RF+                     +        +    L L  G S+G E P++ 
Sbjct: 85  GPILERFAPEARGAGVPEVIESVVTREGNIRHRTTLFKMFCTTLSLGCGASVGREGPVVH 144

Query: 126 VNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWD 184
           +  ++  ++   + L    +  +    +A  I A F  P+A  L  ++ +    ++    
Sbjct: 145 IGSSVGSSLAQLMKLSPEWKRVFLACGAAAGIAATFNAPMAGMLFAAEIILVDFQINY-- 202

Query: 185 RLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCL 244
            L    ++A    + +  F     +  +  +  +   +I    I+  +A    +V +  +
Sbjct: 203 -LSQIAVSAVTATVVSHRFLGSFPTFDVPAFQLLSYWEIPLYLILGVLAGFLAIVFIQLI 261

Query: 245 PRLHAMMHQMKNPVLVL-GIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFL 303
            R+    + MK P+     +GG ++G L ++  P  L  G   + + V       +    
Sbjct: 262 NRVEDSCNLMKLPLWSRPALGGVLVGGLALLS-PYVLGVGYQAINE-VLTADLVPAVMVA 319

Query: 304 LAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLVV 363
           + + KLAA  ++   GF GG   P+              +  +   +    A      +V
Sbjct: 320 ILLAKLAATAISVGVGFSGGIFAPS------------LVLGGLLGGLFGCLAQAFAPHLV 367

Query: 364 TRDGWLSLFMAAVVVPNTTLLPLLCIVMLP 393
                 +L   A +V  TTL P+  I  + 
Sbjct: 368 AEFPVYALVGMAAMVSGTTLAPITAIFTIF 397


>UniRef50_C6BS05 Chloride channel core n=1 Tax=Desulfovibrio salexigens DSM 2638
           RepID=C6BS05_DESAD
          Length = 582

 Score =  103 bits (257), Expect = 1e-20,   Method: Composition-based stats.
 Identities = 80/413 (19%), Positives = 162/413 (39%), Gaps = 30/413 (7%)

Query: 2   LHPRARTMLLLSLPAV-AIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWII 60
           LH RA +     + A   IG  S+L  +V+ +    L          TL +      W+ 
Sbjct: 17  LHKRAPSRNAKLIFAATVIGCCSALAAVVLNRALDYL---------STLRMTNSQHWWMF 67

Query: 61  GVLTLTG-IAVGL---VIRFSQGHA-GPDPACEPLIGAPVPPSALPGLIVALILGLAGGV 115
            +  +   +AV L   + + S GH  G   A   L    + P ++   ++  +L +A G 
Sbjct: 68  MLPAVGATLAVILSKNIFKESGGHGVGEVIAKVGLKQGILRPISIISSLLTSLLTIASGG 127

Query: 116 SLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTL 174
           S GPE P++    A+   +     +   +RM      +AG+I A+F  PV   +   + +
Sbjct: 128 SAGPEAPVVVSGSAMGSNLSRLFKMSGQSRMTLIGCGAAGSISAIFNAPVTGMIFAVEII 187

Query: 175 NGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAI 234
            G         L    +++     T+ L            +  M +TD+ +  ++A +  
Sbjct: 188 LGEWTPYH---LIPIAISSVVATQTSRLLEGNVIPFN-DQFPPMGITDLGTSILLAVLTA 243

Query: 235 AAGMVAVWCLPRLHAMMHQMKN-PVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVAN 293
              ++ V  + ++ +    + N P +    GG  +GI+G+   P++L +G   ++  +  
Sbjct: 244 LVSVLFVRLIRQVGSACSSLTNKPWIKAACGGLAVGIIGIF-FPLALGEGYTSIKMAIHG 302

Query: 294 QAFSTSDYF-LLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGL----MLHEHVPAVPA 348
                      + ++++    +   SG  GG   P + +G   G     ++ + +P    
Sbjct: 303 TLPDGIALIAFMGMLRIVTTSLTLGSGGLGGIFAPCLVIGSLFGAFYYRVISQIIPQNIL 362

Query: 349 AITVSCAILGI---VLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL 398
               S A+LG+   V  V +    S+F+   +      +  + IV   + +L 
Sbjct: 363 TGEGSYALLGMAGVVSGVMQAPLTSVFLVLEITHGYQAVMHIMIVTFLSSMLT 415


>UniRef50_A0LQV7 Cl-channel, voltage-gated family protein n=1 Tax=Acidothermus
           cellulolyticus 11B RepID=A0LQV7_ACIC1
          Length = 587

 Score =  103 bits (257), Expect = 1e-20,   Method: Composition-based stats.
 Identities = 60/306 (19%), Positives = 109/306 (35%), Gaps = 14/306 (4%)

Query: 47  GTLGIAQDSPLWIIGVLTLTGIAVGLVIRF----SQGHA-GPDPACEPLIGAPVPPSALP 101
           G+  +      +++ +  + G+  G +I+     ++GH            G  +      
Sbjct: 89  GSSHLPALGVWFLLLIPAVGGLLYGPLIQRFAPEARGHGVPEVMIAVAENGGRIRSQVTV 148

Query: 102 GLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALF 160
              +A  L +  G S+G E PI+ +  A A +IG  + LP           +AG I A F
Sbjct: 149 VKALASALCIGTGGSVGREGPIVQIGSAFASSIGQIVRLPESRLRILVACGAAGGISATF 208

Query: 161 GTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEM 220
             P+   L   + +     +     L   +++A    +    FF     L    +  +  
Sbjct: 209 NAPMTGVLFGFELILREFSI---GALLPIIVSAVLADIVGRAFFGSGPILSQVPHYLVLP 265

Query: 221 TDILSGA--IVAAIAIAAGMVAVWCLPRLHAMMH--QMKNPVLVLGIGGFILGILGVIGG 276
            D+      ++  IA   G+     L R+  +        P       G I+  + ++  
Sbjct: 266 HDMDFILVGVLGLIAAVIGVGFKSALYRIEDVCDRVWGNRPEWARPAVGGIVLGVLLLAL 325

Query: 277 PVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALG 336
           P     G   M + VA Q ++     LL V K+ A  +    G  GG   P++F+G   G
Sbjct: 326 PQLYGVGYPVMDKAVAGQ-YALWFLLLLMVGKIVAASLTIGIGGSGGVFAPSLFIGATAG 384

Query: 337 LMLHEH 342
                 
Sbjct: 385 TAFGAV 390


>UniRef50_B9XGZ2 Chloride channel core n=3 Tax=Verrucomicrobia RepID=B9XGZ2_9BACT
          Length = 603

 Score =  103 bits (256), Expect = 1e-20,   Method: Composition-based stats.
 Identities = 80/418 (19%), Positives = 155/418 (37%), Gaps = 24/418 (5%)

Query: 10  LLLSLPAVAIGIASSLILIVVMKIASVLQNL-LWQRLPGTLGIAQDSPL--WIIGVLTLT 66
           LLLS  A  IG  S+ +   ++ + S++ N+  + R        QD+ +  W+I +  + 
Sbjct: 24  LLLSGMAAIIGAISAGVAYGLLWLISLITNISFFHRFKVEDVTPQDAHIGAWVIIIPVIG 83

Query: 67  GIAVGLVIRFS----QGHA-GPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEH 121
            + +GL+ R+     +GH          +  + + P       ++  + +  G   G E 
Sbjct: 84  ALIIGLMARYGSPKIRGHGIPEALEAILIGRSKLEPKVAILKPISSAISIGTGGPFGAEG 143

Query: 122 PIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEV 180
           PI+    A          L    R    +  +AG + A+F TP+AA L+  + L      
Sbjct: 144 PIIMTGGACGSLFAQYFHLTAAERKTLLVAGAAGGMAAIFSTPIAAILLAVELL------ 197

Query: 181 PLWDRLFAPLMAAAAGALTTGLFFHPHFS----LPIAHYGQMEMTDILSGAIVAAIAIAA 236
            L++     L+  A  A+       P        P+  +G M   ++L   +V   A  A
Sbjct: 198 -LFEWKPRSLIPVAVSAIMASAMRVPLLGAGPIFPVLPHGAMTGAELLVAGVVGIAAGLA 256

Query: 237 GMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAF 296
                  +  L     ++    +     G +   +G    P  L  G   +  ++  +  
Sbjct: 257 SGAVTTLVYALEDAFKKLPIHWMWWPAIGAVFVGIGGYIDPRVLGVGYKLIHGLLRGE-L 315

Query: 297 STSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAI 356
             +    L + K     +A  SG  GG + P + +G ALG +L   +      +    A+
Sbjct: 316 VGAAVLGLLIGKAIVWSIALGSGTSGGVLAPLLIMGGALGALLSRWIHIGDTGLWAMVAM 375

Query: 357 LGIVLVVTRDGWLSLFMAAVVVPNTTLLPLL---CIVMLPAWLLLAGKPMMMVNRPKQ 411
             ++    R  +     A  +  +   LP +   CI  L   +LL  + ++     ++
Sbjct: 376 GAMMGGTMRAPFTGTIFALELTHDLNALPAVMIGCIASLGVTVLLLRRSILTEKIARR 433


>UniRef50_A5N0V4 ClcA n=2 Tax=Clostridium kluyveri RepID=A5N0V4_CLOK5
          Length = 523

 Score =  103 bits (256), Expect = 2e-20,   Method: Composition-based stats.
 Identities = 76/395 (19%), Positives = 143/395 (36%), Gaps = 19/395 (4%)

Query: 16  AVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIR 75
           ++ +GI +  I+++   +   L   + +     L      PLWII  + L G  +G +++
Sbjct: 24  SIIVGIITGFIIVLFRVVIEELGEKVGKIYEILLLKLYFLPLWIILFIIL-GYILGFMVK 82

Query: 76  FSQGHAGP-DPACEPLIGAPVPPSALPGLI---VALILGLAGGVSLGPEHPIMTVNIALA 131
                 G   P  +  +   +       ++   V   L +  G+SLG E P + +   + 
Sbjct: 83  KDPMVGGSGIPQVKGAVLRKLEMKWFKVILNKFVGGSLAIGFGLSLGREGPSVQLGACVG 142

Query: 132 VAIGARLLPRVNRMEWTILASAGTIGAL--FGTPVAAALIFSQTLNGSSEVPLWDRLFAP 189
             + +R+  RVN  E  ++ S  + G    F  P+A A IF+      +  PL   L + 
Sbjct: 143 QGL-SRIFKRVNIEEKYLITSGASAGLAAAFNAPLAGA-IFALEEIHKNFSPL--ILISA 198

Query: 190 LMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHA 249
             AA +    TG F          H   + +       +   I    G++    L +   
Sbjct: 199 FSAALSADFITGGFLGLSPVFNFKHISAIPLNYYFYILLFGIIMGVTGVIFNIFLLKSQH 258

Query: 250 MMHQMK-NPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIK 308
           +  + K  P     +   +  I+     P  L  G   +  + AN +F+     +L ++K
Sbjct: 259 LYSKQKWIPKEFNPVFPLLTSIIFGFFLPQVLGGGNSLIMSL-ANTSFTIKFILVLIIVK 317

Query: 309 LAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAIT------VSCAILGIVLV 362
               ++   SG  GG   P + +G  +G      +  +    T      V   + G    
Sbjct: 318 FLFTMLCYGSGTPGGIFLPVLTIGALIGYGYGSLLINILNINTNYINNFVILGMAGYFTA 377

Query: 363 VTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLL 397
           V R       +   +         L IV + A+L+
Sbjct: 378 VVRSPITGTILITEMTGGFNNFLPLSIVSIVAYLV 412


>UniRef50_A3EVY7 Putative Cl-channel, voltage gated n=2 Tax=Leptospirillum sp. Group
           II RepID=A3EVY7_9BACT
          Length = 570

 Score =  102 bits (255), Expect = 2e-20,   Method: Composition-based stats.
 Identities = 73/414 (17%), Positives = 150/414 (36%), Gaps = 25/414 (6%)

Query: 14  LPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAV--- 70
           + A+ IGI + L++ ++  +   L  L         GI       I+ V+ + G+ +   
Sbjct: 30  ILALLIGIVTGLLVYLLESVVYELLFLTLYNTYFKNGI-------IVIVIPMIGVLLTRL 82

Query: 71  GLVIRFSQGHAGPDPACEPLIG--APVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNI 128
            LV   + G  G +   +        +P S  P  I A I  L  G S G E     +  
Sbjct: 83  ILVWGKTDGMGGTEEVVKSYHEFRGRLPLSRTPYKIPAYITTLGFGGSAGLEGASTYIGG 142

Query: 129 ---ALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWD 184
              ++A  I  +L +P   +    +  +   + A+F  P+   +   Q    S   P  +
Sbjct: 143 MVSSIAEKIMEKLNIPFEEQRTLLLAGAGAGLSAMFKAPLTGTIFILQVPYKSDLAP--N 200

Query: 185 RLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCL 244
            L   L+A+ +  +        H    +A+     M D+L+  ++  +        +   
Sbjct: 201 ALIPTLVASVSSYIVMVTLKGTHPLFSMANKADFHMNDMLAVIVIGLVCGFLSKYFLRVY 260

Query: 245 PRLHAMMHQMKNPVL-VLGIGGFILGILGV-----IGGPVSLFKGLDEMQQMVANQAFST 298
                   +    +     +   ILGI G       G  + L  G   +Q +++    + 
Sbjct: 261 RATKTWFLKGPARLTSRNVLAALILGITGYLATLRFGEALPLGPGYIFIQYLLSVPD-TF 319

Query: 299 SDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILG 358
            +  +L ++K+AA++   ++G  GG  FP + +G A G ++       P    V   + G
Sbjct: 320 LNLLMLLLLKMAAVIFTFSAGGMGGSFFPLLCLGAATGGLISNVAHIQPFDFGVVMGMAG 379

Query: 359 IVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNRPKQQ 412
            +    +    ++   A    ++  L    I    +++      +    R ++ 
Sbjct: 380 FLAAGYKTPLAAVVFVAESTHSSGYLIPGLICTAFSYIASGASSISSQQRERED 433


>UniRef50_B6YRP1 Voltage-gated ClC-type chloride channel n=33 Tax=Bacteria
           RepID=B6YRP1_AZOPC
          Length = 608

 Score =  102 bits (255), Expect = 2e-20,   Method: Composition-based stats.
 Identities = 77/432 (17%), Positives = 156/432 (36%), Gaps = 48/432 (11%)

Query: 3   HPRARTMLL---LSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWI 59
           H R + +     + + +   GI ++   +++ KI  ++Q  L   +         +    
Sbjct: 27  HWREKHIKEPHFILILSFITGILTAFAGVLLKKIICLIQYFLKNEI-----YTTYNEYSY 81

Query: 60  IGVLTLTGIAVGLVIRFSQGH-----AGPDPACEPLIGAPVPPSALPGLIVALILGLAGG 114
           +    +  +  GL ++F   +                 + +    L   ++A  + +  G
Sbjct: 82  LVCPAIGILFSGLFVKFIAKNDIGHGITKILYAISQRKSRLKMHNLWTSLIASSVTIGFG 141

Query: 115 VSLGPEHPIMTVNIALAVAIGARLLPRVNRMEWTI-LASAGTIGALFGTPVAAALIFSQT 173
            S+G E P +    A+   +G         +   I   +AG I  +F  P+A  L   + 
Sbjct: 142 GSVGAEAPSVITGSAIGSNLGRLFKMDQKTLMLLISCGAAGAIAGVFKAPIAGLLFTIEV 201

Query: 174 LN-GSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAI 232
           L    + V +   L + + AA+   + TG       S  +  Y Q    DI +   V  +
Sbjct: 202 LMLDLTTVSVLPLLISSVTAASISYIFTG-------SEAMFKYNQTVAHDIKNIPYVLLL 254

Query: 233 AIAAGMVAVWCLPRL---HAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQ 289
            +  G++ V+ +  L    ++ +++KN      +G  IL IL V   P    +G D +  
Sbjct: 255 GVTCGLITVYFVRVLIWIESIFNRLKNYWQRFALGAVILNIL-VFLFPPLYGEGYDIIDD 313

Query: 290 MVANQ----------------AFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGV 333
           ++ NQ                  S   + L+   K+ A       G  GG   P++F+G 
Sbjct: 314 LINNQYDQILNNTFVSGMNISGVSVLFFMLVIFTKVFATGATTGGGGCGGIFAPSLFLGC 373

Query: 334 ALGLMLHEHVPA------VPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLL 387
            +G +    +        +P        + G++  +      ++F+ A +     L   L
Sbjct: 374 TIGFIFSHLLNLLGGNNFLPENNFSLIGMAGMMSAILHAPLTAIFLIAELTGGFGLFLPL 433

Query: 388 CIVMLPAWLLLA 399
            IV   A+  + 
Sbjct: 434 MIVSSSAYFTIL 445


>UniRef50_A6CC67 Putative chloride channel n=2 Tax=Planctomycetaceae
           RepID=A6CC67_9PLAN
          Length = 622

 Score =  102 bits (253), Expect = 3e-20,   Method: Composition-based stats.
 Identities = 84/454 (18%), Positives = 157/454 (34%), Gaps = 47/454 (10%)

Query: 7   RTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRL-----PGTLG----------I 51
           +T     + +  IGI + L  IV   +  V+Q+     +     P T+G           
Sbjct: 17  KTSGKWFVLSCLIGIVAGLGGIVFDVLIQVVQHNTLVAIAGFDHPQTVGEHSIYEDEEAR 76

Query: 52  AQDSPLWIIGVLTLTGIAVGLVIRFSQGHA---GPDPACEPLIGAP-VPPSALPGL-IVA 106
              SP W++ V+T  G+  G+++      A   G D A +       +    +P +  +A
Sbjct: 77  KAFSPWWMLAVITAGGLVSGIIVYNIAPEAEGHGTDAAIDAFHNKRGLILPRVPIVKTIA 136

Query: 107 LILGLAGGVSLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVA 165
             L L  G S G E PI  +       +   L L   +R           IGA+F  P+A
Sbjct: 137 SALTLGTGGSAGREGPIAQIGAGFGSWVATVLKLSARDRRIMLAAGVGAGIGAIFRAPLA 196

Query: 166 AALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTT------GLFFHPHFSLPIAHYGQME 219
            AL  ++ +  +++    D +    M++              L F P F   + H     
Sbjct: 197 GALFAAEIMYSNADFE-SDVIVPAAMSSIIAYSVYCMSLPQELQFMPLFGDGLHHTVDSH 255

Query: 220 MTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMK-NPVLVLGIGGFILGILGV----- 273
              I    +   +++A  M  V      +     +   P+    IG F+ GI+G+     
Sbjct: 256 FELIPYTILSVILSLA-AMFYVKTFYGTNRFFKSIPIKPMFKPAIGAFLTGIVGIGMYYL 314

Query: 274 ----IGGPVSLFKGLDEMQ-QMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPA 328
               +     +  G   +Q  + +    S      +AV+K+    +   SG  GG   P+
Sbjct: 315 FNKDLQALTVMSTGYGILQDALTSAAQISIPLLLTVAVVKVFTTSLTIGSGGSGGVFGPS 374

Query: 329 VFVGVALGLMLHEHVPAVPAAITVSCAILGIV------LVVTRDGWLSLFMAAVVVPNTT 382
           + +G  +G      +  +   +       G+V               ++ M + +  N +
Sbjct: 375 MVIGGCVGTATGRILQDLWPEMVTQPEAYGLVGMAGFFAGAAHAPISTIIMVSEITGNYS 434

Query: 383 LLPLLCIVMLPAWLLLAGKPMMMVNRP-KQQPPH 415
           LL    +     ++L     +     P +   P 
Sbjct: 435 LLLPTMLSSTLCFVLCQKVHLYQKQYPSRLDSPA 468


>UniRef50_A6TUH7 Chloride channel, core n=2 Tax=Firmicutes RepID=A6TUH7_ALKMQ
          Length = 437

 Score =  102 bits (253), Expect = 3e-20,   Method: Composition-based stats.
 Identities = 55/351 (15%), Positives = 127/351 (36%), Gaps = 12/351 (3%)

Query: 63  LTLTGIAVGLVIRFSQGHA--GPDPACEPLIGA--PVPPSALPGLIVALILGLAGGVSLG 118
           L L GI +G +  +    +  G D   E +      +P    P + V   +    G S G
Sbjct: 66  LPLGGIVIGYIYMYYGKGSRKGNDLIIEHVHHGQGKIPLRMGPIVFVCTFITHLLGGSTG 125

Query: 119 PEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGS 177
            E   + +  +++  +     +  ++R    I   +G  G+ FG P+A  +   + +   
Sbjct: 126 REGAAIQMGASISEGVNRFFNVAEIDRRILIISGISGGFGSAFGAPLAGTIFGMEAI--V 183

Query: 178 SEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAG 237
                ++      +A+  G      +   H    I +   +   +++   I++ I     
Sbjct: 184 IGKTKYEAFIPCFVASFIGHFVATAWGIHHDEFIIQNIPDINTVNLMKVIILSIIFGFTS 243

Query: 238 MVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFS 297
           ++       +  +  +    +++    G I+ I          + G       +  +AF+
Sbjct: 244 VLYSQLRHEIKRLSDKYLKNLMLRAFVGGIIIITLTYLIGSRDYLGRG---LPMVERAFT 300

Query: 298 TSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAIL 357
                   + K+    +   +GFRGG + P  F+G  LG  L   + A+PA+   +  ++
Sbjct: 301 GDVPPFAFLAKIIFTAITMGTGFRGGEVIPLFFIGSTLGNTLSPIM-ALPASFLAALGMI 359

Query: 358 GIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNR 408
            I+        +S F+ +V +     +    +  L +++      +    +
Sbjct: 360 AILSGAANTP-ISAFIFSVEMFKGEGITFFFMACLISFIFSGHHGIYGAQK 409


>UniRef50_B0SCW6 Chloride channel protein n=2 Tax=Leptospira biflexa serovar Patoc
           RepID=B0SCW6_LEPBA
          Length = 420

 Score =  101 bits (252), Expect = 4e-20,   Method: Composition-based stats.
 Identities = 64/334 (19%), Positives = 116/334 (34%), Gaps = 12/334 (3%)

Query: 47  GTLGIAQDSPLWIIGVLTLTGIAVGLVIR-FSQGHAGPDPACEPLIGAP---VPPSALPG 102
            ++   ++S  +++  L L G  +G V   F    +  +      I +P   +P    P 
Sbjct: 42  DSVTKLRESHTYVLYFLPLVGFFIGWVYHQFGSKASKGNNLLLEEIHSPSSVIPIRMAPL 101

Query: 103 LIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFG 161
           ++   +L    G S G E   + +  ++A  I     L    +    IL  +    A+FG
Sbjct: 102 VLFGTLLTHFFGGSAGREGTAVQMGGSIAHQIVRFYRLSLKEQQTLIILGMSAGFSAVFG 161

Query: 162 TPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMT 221
           TP+AAA+   + +        W      L+ A         +   H   P   + + E  
Sbjct: 162 TPIAAAIFSIEVI--QIGAYRWKLFLPSLLIAWISHEVCLYWKVSHSVFPNVTF-EFESI 218

Query: 222 DILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLF 281
            IL   ++A  +     +  W L  +                 G I+ ++  + G    +
Sbjct: 219 LILVLFLLAIASGFVAKLFTWLLHSISKYSQTWIVYPPFRPFVGGIILVVFFLSGVHLDY 278

Query: 282 KGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHE 341
            G   +       AF+    +     KL   V+    GF+GG + P  F+G +LG +   
Sbjct: 279 FG---LGVKTIQNAFTGFLPYESFFWKLILTVITIGFGFKGGEVTPLFFIGASLGNLFAI 335

Query: 342 HVPAVPAAITVSCAILGIVLVVTRDGWLSLFMAA 375
             P V   + VS   + +    T        M  
Sbjct: 336 LDP-VHLTLFVSVGFISVFSGATNTPLACAVMGM 368


>UniRef50_C4G1J1 Putative uncharacterized protein n=1 Tax=Abiotrophia defectiva ATCC
           49176 RepID=C4G1J1_ABIDE
          Length = 434

 Score =  101 bits (252), Expect = 4e-20,   Method: Composition-based stats.
 Identities = 54/322 (16%), Positives = 116/322 (36%), Gaps = 12/322 (3%)

Query: 59  IIGVLTLTGIAVGLVIRFS---QGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGV 115
           I+  L   G+ +  + RF+   +                +P    P +  + ++  A G 
Sbjct: 60  ILFGLPFAGLIIVYLYRFAGVYKSKGTNLVISTIQAKTELPVVMAPLIFASTLITHAFGG 119

Query: 116 SLGPEHPIMTVNIALAVAIGA---RLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQ 172
           S+G E   + +  A A  +       L    +    +   +    A+FGTP+AA     +
Sbjct: 120 SVGREGAALQLGSAAAAGLNKIKWLKLSEEEKRMIIMCGMSAAFSAIFGTPIAAVFFPME 179

Query: 173 TLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAI 232
               S  +  +  +F   +++      + L+      L       +    +   A++A +
Sbjct: 180 V--ASIGIIQYSAMFPCFVSSVTARWLSHLYGLEKEHLGRVTDVGLNFDVVWKIALLAIV 237

Query: 233 AIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVA 292
                ++    L        ++          G  + I+  I      F G       V 
Sbjct: 238 CGLLSIIFCLLLKGAGTAFSKLHINRYFQIFVGGTIFIVINILLDTKDFLG---AGMPVI 294

Query: 293 NQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITV 352
            +A      +   ++K+    +   +G++GG I P++F+G   G +   H+  +P ++ V
Sbjct: 295 ERAVEGEVVWYAFLMKMLLTALCIGAGYKGGEIVPSLFIGATFGNLFA-HLFGLPTSLAV 353

Query: 353 SCAILGIVLVVTRDGWLSLFMA 374
           +C + G+ + VT     SL + 
Sbjct: 354 ACGMAGLFVGVTNCPIASLLII 375


>UniRef50_D1XZY9 Chloride transporter, ClC family n=2 Tax=Prevotella
           RepID=D1XZY9_9BACT
          Length = 604

 Score =  101 bits (252), Expect = 4e-20,   Method: Composition-based stats.
 Identities = 63/413 (15%), Positives = 132/413 (31%), Gaps = 30/413 (7%)

Query: 12  LSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVG 71
           + + A  +G+ +S+   V+  +   ++ LL         +     L+ +  + LT + + 
Sbjct: 33  VYILAFLVGVLASVAAYVLHTMICEIEELLTSGF-KMTNVNWLYLLYPVIGIWLTTLFIK 91

Query: 72  LVIRFSQGHA-GPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIAL 130
            V+R S  H             + +        IVA  + +  G S+G E PI+    A+
Sbjct: 92  YVVRDSISHGITRVLYALATNKSKIKGHNTWTSIVASAITIGFGGSVGAEAPIVLTGSAI 151

Query: 131 AVAIGARLLPRVNRMEWTI-LASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAP 189
              +G         +   +    A  + A+F  P+A  +   + L     +     L   
Sbjct: 152 GSNLGKLFKLDDRTLMLLVGCGGAAAVSAIFKAPIAGLVFTLEILMVDLTMA---SLLPI 208

Query: 190 LMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHA 249
           L+A       + LF             + ++  I +  ++        +  +  +     
Sbjct: 209 LIATVTATCFSYLFTGGSSMYAFHVDYEWQLHRIPATILLGIFCGFLSLYFMRVMTWCED 268

Query: 250 MMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVA----------------- 292
              ++        + G ++    +   P    +G D M+  +                  
Sbjct: 269 GFGKLSKYPYTKLLVGALVLSSLIFLFPSLYGEGYDSMRVFIEGKTVEDWQSVLRGSMFA 328

Query: 293 -NQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPA------ 345
            N  +      L+ + K+ A      SG  GG   P +F+G   G               
Sbjct: 329 GNAKYLVLYVGLVMITKVFATSATNGSGGCGGTFAPTLFIGGFAGFFFSRVWNMQEVGLY 388

Query: 346 VPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL 398
           VP        +  ++  V       +F+ A +     L   L IV + ++L +
Sbjct: 389 VPEKNFTLYGMAALMSGVMHAPLTGIFLIAELTGGYQLFIPLLIVSISSYLTI 441


>UniRef50_A9BT15 Chloride channel core n=9 Tax=Bacteria RepID=A9BT15_DELAS
          Length = 431

 Score =  101 bits (252), Expect = 5e-20,   Method: Composition-based stats.
 Identities = 75/388 (19%), Positives = 147/388 (37%), Gaps = 15/388 (3%)

Query: 27  LIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRFSQG--HAGPD 84
             +V  +A          L       +  P WII +L   G+AVGLV          G +
Sbjct: 23  ATLVAALAGTASAFFLLSLDLATAWREAHP-WIIWLLPFAGMAVGLVYFLLGKRVDGGNN 81

Query: 85  PACEPLIGAP--VPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARL-LPR 141
              E +      VP   +P ++   ++    G S+G E   + +  ALA  +     L +
Sbjct: 82  LLIEEIHDPKQVVPLRMVPLVLGGTVISHLFGASVGREGTAVQMGGALADQLTHVFRLHQ 141

Query: 142 VNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTG 201
            +R    +   +    ++FGTP+A A+   + L  +     +D LF  ++AA        
Sbjct: 142 DDRRVLLMSGISAGFASVFGTPLAGAVFGLEVL--AIGRMRYDALFPCIVAAFVADQVCT 199

Query: 202 LFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMM-HQMKNPVLV 260
            +   H    ++    ++   +++  I   +    GM+    + ++ A++ H +  P L 
Sbjct: 200 AWGVHHTHYAMSAVNNIDAWSVVAVIIAGILFGLVGMLFATAVHKIGALVKHLIAYPPLR 259

Query: 261 LGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGF 320
              GG ++    V       + GL  +  +  +       +  L   KL   V +  +GF
Sbjct: 260 PFFGGLVIAT-AVWALDAYRYIGLG-IPDIARSFQEPMLPWDFLG--KLVFTVASLGTGF 315

Query: 321 RGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPN 380
           +GG + P  ++G  +G +L   +  +P A+  +   + +          +  MA  +   
Sbjct: 316 KGGEVTPLFYIGATMGNVLAPLL-HMPFALMAAIGFVAVFAGAANTPIATTLMAMELF-G 373

Query: 381 TTLLPLLCIVMLPAWLLLAGKPMMMVNR 408
             + PL  I  + A+L      +    R
Sbjct: 374 AGIGPLAAIGCVTAYLFSGHAGIYHAQR 401


>UniRef50_Q6SGK9 Voltage-gated chloride channel n=4 Tax=Bacteria RepID=Q6SGK9_9BACT
          Length = 592

 Score =  101 bits (251), Expect = 5e-20,   Method: Composition-based stats.
 Identities = 70/416 (16%), Positives = 140/416 (33%), Gaps = 19/416 (4%)

Query: 8   TMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTG 67
           ++L  SL  V  G+AS L+++   +  + L   LW             PL+   +  +  
Sbjct: 35  SVLAYSLLGVIGGVASGLVILGFEESIAYLAA-LWGVGNSGEDFESLPPLFRFLLPAIGA 93

Query: 68  IAVGLVIRFSQGH-----AGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHP 122
           + +G+  +  +            +        +P              LA G S G E P
Sbjct: 94  LLLGICYQMLRNEDREVGIVHVLSRMHSHYGALPARNAIIQFFGGAFALASGQSGGREGP 153

Query: 123 IMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVP 181
            + +  A+   +G RL LP  +        +AG I A F TP+A  +   + +     V 
Sbjct: 154 GVHLGGAINSLLGQRLGLPNNSLRVLIACGTAGGIAAAFNTPLAGVIFAMEVIIAEYTV- 212

Query: 182 LWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAV 241
                   ++AA + +  +  F        I       + +I    ++      A +  V
Sbjct: 213 --VGFIPVMLAAVSASAVSRTFATGGAVFNIPSLQLTSLWEIPYIVLLGFSCGLAVVAFV 270

Query: 242 WCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDY 301
                   + H   + V+       ++     +  P  +  G D + ++  N   +    
Sbjct: 271 QISKHTARLSH---HAVIFRFTAAGVITGALALFVPEIMGIGYDTL-RLALNGEVALLAL 326

Query: 302 FLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLH----EHVPAVPAAITVSCAIL 357
            ++A  K+ A  +   +G   G I P + +G  LG  +     + +P + +  T+   ++
Sbjct: 327 VVIAGAKIIATSITVGAGMPVGIIGPNLLIGACLGGAMGMIGNQFMPGLASDPTLY-ILI 385

Query: 358 GIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNRPKQQP 413
           G+   +       L     V+  T  + +    ML           +   R   Q 
Sbjct: 386 GMGSAMGAIMNAPLAAILAVLELTHSMSIAMPAMLAIVAATLTHTGLFRQRSLHQT 441


>UniRef50_A5VU61 Voltage gated chloride channel family protein n=40 Tax=Rhizobiales
           RepID=A5VU61_BRUO2
          Length = 490

 Score =  101 bits (251), Expect = 6e-20,   Method: Composition-based stats.
 Identities = 82/397 (20%), Positives = 152/397 (38%), Gaps = 22/397 (5%)

Query: 7   RTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLT 66
           +  L+    A+AIGI    I +   + A + Q+  +  L     +    PL I  +  + 
Sbjct: 64  KPRLVFWCGALAIGI----ISVGFAEAADIAQDW-FHSLTSGSPLRAWLPLLITPLGFMF 118

Query: 67  GIAVGLVIRFSQGHAGPDPACEPLIGAP-------VPPSALPGLIVALILGLAGGVSLGP 119
              V LV   + G +G   A               +      G IV  I+GL  G S+G 
Sbjct: 119 CSWVALVWFPNSGGSGIPQAIAARHLNDHEDRSLLLSIRVATGKIVLTIIGLFCGASIGR 178

Query: 120 EHPIMTVNIALAVAIGARLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLN-GSS 178
           E P + +  ++ +   AR           +  SA  I A F TP+A  +   + +    +
Sbjct: 179 EGPTVQIGASI-MLQAARFGGMEKARGLILAGSAAGIAAAFNTPLAGIVFAIEEMGRAYA 237

Query: 179 EVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGM 238
                  L A ++A  A     G + +  F+   A  G+  +  I  G    A   A   
Sbjct: 238 ARTNGLVLSAVILAGLASLGLVGNYNYFGFTTVTASTGKDWILTIACGIFGGAFGAAFSA 297

Query: 239 VAVWCLPRLHAMM--HQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAF 296
           +A+    R+   +    ++N V+  GI G ++ ++G+  G ++   G D+ +  V     
Sbjct: 298 LALNMGRRVRRRVQKAPLRNMVIFAGICGLLVALIGIASGGMTFGAGYDQARSAVEGATL 357

Query: 297 STSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAI 356
               +    V K    +++  SG  GG   P++ VG  LG  +   +    A++     +
Sbjct: 358 PPFYF----VEKFTVGLLSMISGIPGGIFAPSLSVGAGLGSTIGLLL-GTSASLAAVLGM 412

Query: 357 LGIVLVVTRDGWLSLFMAAVVV-PNTTLLPLLCIVML 392
            G      +    +  +   +   ++ ++PL+C  ML
Sbjct: 413 AGYFAGAVQAPMTAFVIILEMTGNHSNVIPLMCASML 449


>UniRef50_D0LKI3 Cl-channel voltage-gated family protein n=1 Tax=Haliangium
           ochraceum DSM 14365 RepID=D0LKI3_HALO1
          Length = 651

 Score =  101 bits (251), Expect = 6e-20,   Method: Composition-based stats.
 Identities = 73/372 (19%), Positives = 131/372 (35%), Gaps = 25/372 (6%)

Query: 50  GIAQDSPLWIIGVLTLTGIAVGLV-IRFSQG--HAGPDPACEPLI--GAPVPPSALPGLI 104
                    II    L G+A GLV  RF+     AG D   +     G  +        +
Sbjct: 92  SGGVLQWALIILTPALGGLAAGLVSWRFAPETEGAGVDNVLDAYHNRGGRMRKRTPTVKL 151

Query: 105 VALILGLAGGVSLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTP 163
           +  +  L  G S G E P+  +   +   +  R  L +  R    +  +AG + ALF  P
Sbjct: 152 ITTLFTLGSGGSAGREGPMAQIGAGVGAYVADRFGLSKRERRLLLLAGAAGGVSALFRAP 211

Query: 164 VAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDI 223
           + AAL   + L         + LF  L+++          + P     ++     + T +
Sbjct: 212 LGAALWSLEVLYRKDFE--SEGLFPCLVSSVTAYSVFTTIYEPGSLFFVSVRYHFQPTQL 269

Query: 224 LSGAIVAAIAIAAGMVAVWCLPRLH-AMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFK 282
           L   ++A +    G++ +  L +    +   M+ PV +    G +   +  +  P     
Sbjct: 270 LFYGLMALVCAPFGLLWITLLRQARTRLWEPMRVPVWLKPALGGLALGIFCVFVPWVFST 329

Query: 283 GLDEMQQMV-----ANQAFSTSD-----YFLLAVIKLAALVVAAASGFRGGRIFPAVFVG 332
           G   MQ  +      ++              LAV K+ A  +  +SG  GG   P +F+G
Sbjct: 330 GYGWMQDALRPIGDTSRNLPVGYQGFAMLLGLAVAKMIATSLTVSSGGSGGVFAPTLFIG 389

Query: 333 VALGLM----LHEHVPAV--PAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPL 386
             +G       H   P +    +  V   +      V R    ++ + + +  +  LL  
Sbjct: 390 GFIGGAFGQLFHVLAPGIVSQPSAFVLVGMGAFYAGVARTPIATIILISEMFGSYDLLVP 449

Query: 387 LCIVMLPAWLLL 398
           L    +    LL
Sbjct: 450 LMFCEMITMRLL 461


>UniRef50_Q1CYU1 Voltage-gated chloride channel n=2 Tax=Cystobacterineae
           RepID=Q1CYU1_MYXXD
          Length = 677

 Score =  100 bits (250), Expect = 7e-20,   Method: Composition-based stats.
 Identities = 73/379 (19%), Positives = 125/379 (32%), Gaps = 34/379 (8%)

Query: 43  QRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRFSQGHAGP----DPACEPLIGAPVPPS 98
             LP    +       ++   TL G+ VG ++R      G                +P  
Sbjct: 145 HNLPE--ALPHLPWWLMLLAPTLGGVVVGRLLRDKPETHGHGVPEVVRAVKSGANALPAD 202

Query: 99  ALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARLLPRVNRMEWTI-LASAGTIG 157
                +VA  + +  G S G E PI+    A A  +G  L      +   +   +   I 
Sbjct: 203 RGLLKLVASAITIGSGGSAGREGPIVYGGAAFASTVGRVLGFSRKELSILLACGAGAGIS 262

Query: 158 ALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQ 217
           A F  P+A A+   + +    E+ ++      ++A+ AG L +         L    Y  
Sbjct: 263 ASFNAPIAGAVFAMEIILREFELRVFS---PIILASVAGTLVSQGVMGESAMLRHVPY-- 317

Query: 218 MEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMK-------------NPVLVLGIG 264
            E+         A + IA G++A   +  LH + H                 P+ +    
Sbjct: 318 -ELVSGGEVLAYAGLGIACGLLAFTFVQLLHGVEHYFHGHGKDRLSSWLGSKPLPLRAGL 376

Query: 265 GFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGR 324
           G +   +     P     G D +  + A             ++KL A  +   SG  GG 
Sbjct: 377 GGLCTGILAFASPTVWGSGHDYIN-LAALGRLPFLFLITACLLKLVATALTIGSGGSGGT 435

Query: 325 IFPAVFVGVALGLMLHEHV------PAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVV 378
            FPA  +G   G      V         P+       + G V  +TR     + M   + 
Sbjct: 436 FFPAALIGAMAGGAFGTLVHFFFPESTGPSGAYALVGMGGAVAALTRGPLTGMMMLYELS 495

Query: 379 -PNTTLLPLLCIVMLPAWL 396
             +  +LPL+    + + L
Sbjct: 496 GNHDIILPLMVTCTIASAL 514


>UniRef50_B5YBN2 SycA n=1 Tax=Dictyoglomus thermophilum H-6-12 RepID=B5YBN2_DICT6
          Length = 426

 Score =  100 bits (250), Expect = 8e-20,   Method: Composition-based stats.
 Identities = 62/324 (19%), Positives = 117/324 (36%), Gaps = 16/324 (4%)

Query: 58  WIIGVLTLTGIAVGLVIRFSQ---GHAGPDPACEPLI--GAPVPPSALPGLIVALILGLA 112
           +   +L        L+I          G +   E +      + P  +P  ++  I+ L+
Sbjct: 52  YYYILLPFALFITALIIEKIAPEAKGHGTEKVIESIHKRNGKINPLVVPIKLIGTIITLS 111

Query: 113 GGVSLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFS 171
            G S G E P   +   LA        L   NR +  I   +    ++FGTP+A A+   
Sbjct: 112 AGGSAGKEGPSAQIGAGLASIFADIFKLDDRNRKKLVICGISAGFASVFGTPIAGAIFGI 171

Query: 172 QTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAA 231
           + L        ++ L    +A       +      +   P++              I   
Sbjct: 172 EVL--IVGNMFYEALLPSFIAGIVSFQVSSKLGISYSYHPLSFNYSFNELHFAEAIIAGI 229

Query: 232 IAIAAGMVAVWCLPRLHAMMHQMK--NPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQ 289
                 ++ +  L     +  ++K  NPV  L IGG IL +L +I     L  G+D +++
Sbjct: 230 FLGLVSIIFIETLNFFEDIYKKLKIWNPVKGL-IGGSILVLLTLIFSKNFLGLGIDTIER 288

Query: 290 MVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAA 349
            +  +  +   +     +K+   ++  + G  GG I P  F+G   G  L   +    A 
Sbjct: 289 ALNGERIAWYFFL----VKIIFTIITLSFGGSGGIITPIFFIGSTAGNFLANFLHFDRAT 344

Query: 350 ITVSCAILGIVLVVTRDGWLSLFM 373
           ++    ++ ++  VT     S  M
Sbjct: 345 LSAIG-MINLLASVTNTPIASSIM 367


>UniRef50_B5ILG4 Cl-channel, voltage gated n=1 Tax=Cyanobium sp. PCC 7001
           RepID=B5ILG4_9CHRO
          Length = 672

 Score =  100 bits (250), Expect = 8e-20,   Method: Composition-based stats.
 Identities = 83/327 (25%), Positives = 137/327 (41%), Gaps = 18/327 (5%)

Query: 51  IAQDSPLWIIGVL-TLTGIAVGLVIRFSQGHAGPDPACEPLIGA--PVPPSALPGLIVAL 107
           +     LW + V+ TL G+AVGL+ RF        P+   +        P      ++  
Sbjct: 128 LPDWISLWPVVVVPTLGGLAVGLLRRFGGDLGPGLPSLMAMAEGTEAPAPRLPLLRLLGA 187

Query: 108 ILGLAGGVSLGPEHPIMTVNIALAVAIGAR-LLPRVNRMEWTILASAGTIGALFGTPVAA 166
            L L  G SLGPE P +     L + +  R  LP   +        A  + A F  P+A 
Sbjct: 188 ALSLGSGASLGPEGPSVESGGNLGLWVALRGGLPPQRQKALVAAGVAAGLAAGFKAPIAG 247

Query: 167 ALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFH--PHFSLPIAH-YGQMEMTDI 223
             +F       S +     L A L+AA A AL T L     P   LP       +E+   
Sbjct: 248 --VFFAFEGSFSAIQGRPSLRAVLVAAVASALVTQLVLGDAPILRLPAYEVRSPLELPLY 305

Query: 224 LSGAIVAAIA--IAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLF 281
           L   ++A++   +   ++A+    RL   + ++    L   +GG  +G++  +G P  L 
Sbjct: 306 LGLGVLASLMSWLLVRLLALGRDQRLQRWLARLPA-ALPTALGGAAVGVMA-LGFPQVLG 363

Query: 282 KGLDEMQQMVAN-QAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLH 340
            G D ++ ++ +          LL  +KL A  V+ A+GF GG   PA+ +G  LG    
Sbjct: 364 VGYDTVEALLGSDGGIPLLTLLLLLGVKLLATTVSNATGFVGGGFAPALVLGAVLGNGYG 423

Query: 341 EHVP----AVPAAITVSCAILGIVLVV 363
           + +      +P A   + A++G+  V+
Sbjct: 424 QLLGDAGLQLPVAEPPAYAMVGMAAVL 450


>UniRef50_A6Q6W6 Voltage-gated chloride channel n=4 Tax=Epsilonproteobacteria
           RepID=A6Q6W6_SULNB
          Length = 467

 Score =  100 bits (249), Expect = 1e-19,   Method: Composition-based stats.
 Identities = 67/336 (19%), Positives = 119/336 (35%), Gaps = 15/336 (4%)

Query: 50  GIAQDSPLWIIGVLTLTGIAVGLVIRFSQGHAGP----DPACEPLIGAPVPPSALPGLIV 105
                +  +++    +    V LV  F+    G       +        +  S +P  ++
Sbjct: 49  SFLPFNYYYLLPFALV--FTVWLVKTFAPSAEGHGTEKVISAVHKSDGKIDVSVIPVKLL 106

Query: 106 ALILGLAGGVSLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPV 164
           A ++ +  G S+G E P   +   +A A+       + +R +  I   +     +FGTPV
Sbjct: 107 ATVISIFAGASVGKEGPGAQIGAGVASALSELFKFSKQDRKKLVICGISAGFATVFGTPV 166

Query: 165 AAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDIL 224
           A A+   + L     V L+D L    +A    A TT  F    ++    H+ Q    D  
Sbjct: 167 AGAIFGVEVL--IIGVILYDVLLPSFIA-GFAAFTTAQFLGIKYTYYNLHFYQDISLDFG 223

Query: 225 SGAIVAAIAIAAGMVA----VWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSL 280
               V   A+  G V+             +     N  L    GG ++ IL +I G   +
Sbjct: 224 LIIKVVIAALFFGFVSDIVITSVSHTAKVIKELKFNIYLKAFAGGLLIVILTLIFGEEYI 283

Query: 281 FKGLDEMQQMVANQAFSTSDY-FLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLML 339
             GLD +   V   +    D  +   ++K     ++  +G  GG I P  ++G   G   
Sbjct: 284 GLGLDTINHTVNPNSTYLLDIHWYTFLLKTLFTSLSLGAGGSGGIITPIFYIGATSGHAF 343

Query: 340 HEHVPAVPAAITVSCAILGIVLVVTRDGWLSLFMAA 375
              +      I  +   + ++   T     S  MA 
Sbjct: 344 GALIAPEHVIIFSALGFVSVLSATTNTPIASTIMAV 379


>UniRef50_B7CDF1 Putative uncharacterized protein n=1 Tax=Eubacterium biforme DSM
           3989 RepID=B7CDF1_9FIRM
          Length = 406

 Score =  100 bits (249), Expect = 1e-19,   Method: Composition-based stats.
 Identities = 59/355 (16%), Positives = 134/355 (37%), Gaps = 12/355 (3%)

Query: 63  LTLTGIAVGLVI----RFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLG 118
           L   G+A+  +     R S+   G     +      +P    P ++V+  +    G S G
Sbjct: 59  LPFAGLAIVFLFDHWGRISRKGMGLVFEVDQGKSDWIPLRMAPFMVVSTWITHFFGGSAG 118

Query: 119 PEHPIMTVNIALAVAIGARLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSS 178
            E   M +   ++   G     + + + + +   A     LFGTP+ A     + L   +
Sbjct: 119 REGVAMQIGATVSHYFGKYFRFKNSGVIFMVAGMAAGFAGLFGTPITAIFFALEVL--VA 176

Query: 179 EVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGM 238
               +  +   + A+   A  +GLF     +  I +  ++ M   +   ++  +    G 
Sbjct: 177 GTLKYRAMSCAIPASFTAAYVSGLFGLHKSTFKIGNVAELNMELSIKLLVLGILFGMVGG 236

Query: 239 VAVWCLPRLHAMMH-QMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFS 297
           +  + L    A +  ++ NP   + + G I+ IL +       + G+ E   ++     S
Sbjct: 237 LFAYFLKHTKAFVTNKITNPYKRIFMMGIIVAIL-LFVFGKCRYSGVGE--NLIVGSFTS 293

Query: 298 TSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAIL 357
              Y    ++K    ++  ++GF+GG + P   +G +LG+++       P  +       
Sbjct: 294 EKIYSYDWILKFILTILTLSAGFQGGEVTPLFAIGSSLGVIIAPVFGLNPLFVASLGYCS 353

Query: 358 GIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNRPKQQ 412
             V     + +L+     + V      P   +V   ++++   + +  + R  ++
Sbjct: 354 --VFGAATNTFLAPIAIGMEVFGYQYFPFFFVVCAISYIVNQNESIYALQRQVRE 406


>UniRef50_Q701W5 Putative chloride channel protein n=1 Tax=uncultured crenarchaeote
           RepID=Q701W5_9CREN
          Length = 648

 Score =  100 bits (249), Expect = 1e-19,   Method: Composition-based stats.
 Identities = 74/399 (18%), Positives = 134/399 (33%), Gaps = 34/399 (8%)

Query: 17  VAIGIASSLILIVVMKIASVLQNLLWQR--------------LPGTLGIAQDSPLWIIGV 62
           + IG+ S L++I   +   +  +                   L     +    P  I  +
Sbjct: 32  IIIGVLSGLLVITAYEAMRIFSSFFLSDVVRYIQPYPEDVANLSSEYSLYVLKPWLIPVI 91

Query: 63  LTLTGIAVGLV---IRFSQGHAGPDPACEPLIGAP--VPPSALPGLIVALILGLAGGVSL 117
           L L G+ +GL+   +  S G  G D   +        +          +  L +  G S 
Sbjct: 92  LGLIGLVIGLLSMKLSTSLGQNGIDEISDEFHNKKNKLSIKNSSLKTFSSFLAIGSGTSG 151

Query: 118 GPEHPIMTVNIALAVAIGARLLPRVNRMEWTIL-ASAGTIGALFGTPVAAALIFSQTLNG 176
           G E  +      LA  IG         +   I      TIG +   P   A+   + L  
Sbjct: 152 GVEDSLAHTGSTLASIIGRIFKLDQEEIRIAIAAGMGSTIGGILRLPFGGAIFSLELLYR 211

Query: 177 SSEVPLWDRLFAPLMAAAAGALTTGLFFH-PHFSLPIAHY-GQMEMTDILSGAIVAAIAI 234
              +     L+   +A+    + +G+    P F      +  +  +  I +  ++AAI  
Sbjct: 212 RDFI--IKSLYPAFLASITSYIVSGVVLDWPSFLYIPQEFITKTTLQSIAAYGVIAAIIG 269

Query: 235 AAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQ 294
             G+  V  +         MK P+      G ++  +  IG P  L  G   +Q      
Sbjct: 270 IVGIGYVKTVQIFQRHFENMKIPLYFKPALGGVIIGIFAIGFPEILGTGYGWLQLAALGN 329

Query: 295 AFSTSDYFLLAVI--KLAALVVAAASGFRGGRIFPAVFVGVALGLML-------HEHVPA 345
                 + +  VI  K+ A  V+ AS    G + P++ +G  +G  L          +  
Sbjct: 330 HEVFPLWIMFPVIAMKIFATSVSNASRNTTGLLGPSLVIGGLIGSALITLFHSFGIFLFI 389

Query: 346 VPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLL 384
              + T+  +I       TR    ++ +   +V + TLL
Sbjct: 390 DTTSATLI-SIFAFFTASTRTPISAIVVGVEMVGSYTLL 427


>UniRef50_UPI000196B5DC hypothetical protein CATMIT_00127 n=1 Tax=Catenibacterium mitsuokai
           DSM 15897 RepID=UPI000196B5DC
          Length = 521

 Score =  100 bits (248), Expect = 1e-19,   Method: Composition-based stats.
 Identities = 74/409 (18%), Positives = 146/409 (35%), Gaps = 22/409 (5%)

Query: 1   MLHPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWII 60
           +L  R++    L+   + +GI S  + IV   + S  +++ +             PLWII
Sbjct: 11  VLRERSKLNKRLAYEGLLVGIVSGAVCIVYRLVLSNAESIYFTIRDFVAHNVSYWPLWII 70

Query: 61  GVLTLTGIAVGLVIRFSQGHAGPDPACEPLIGAPVP---PSALPGLIVALILGLAGGVSL 117
           G++ L  I    +           P  E  +   +       L     A  L L GG+SL
Sbjct: 71  GLIVLGLIISIFLKWEPMIGGSGIPQLEAEVQGRIDECWWRVLLAKFCAGALALVGGLSL 130

Query: 118 GPEHPIMTVNIALAVAIGAR-LLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNG 176
           G E P + +   +  A+  +    +          +A  + A F  P+A  +   + ++ 
Sbjct: 131 GREGPSIQLGGMIGKALAKKGKRVKTEERYLMTAGAAAGLSAAFNAPLAGIMFALEEVHK 190

Query: 177 SSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSL-PIAHYGQMEMTDILSGAIVAAIAIA 235
           +            L++    ++T        F L P   +   E   + +   V  + I 
Sbjct: 191 NFSTS-------ALVSVMIASITADFLSRNIFGLSPTLAFSIKETFPLKNYIWVIILGIV 243

Query: 236 AGMVAVWCLPRLHAMMHQMKN-PVLV---LGIGGFILGILGVIGGPVSLFKGLDEMQQMV 291
           AG++  +        +   K  P L      I   +L  +     P+ +  G  ++ + +
Sbjct: 244 AGVLGAFYNKVTMGTIKLYKKTPSLKKHQRVIIPLVLSGILGFYCPLVMGGG-HKLVEYL 302

Query: 292 ANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEH-----VPAV 346
                  S   LL ++KL    V+  SG  GG  FP + +G  +G  + +      VP+ 
Sbjct: 303 NEPNLVLSTLVLLFILKLLISCVSFGSGAAGGIFFPLLILGSLIGASVGKVAIMCGVPSE 362

Query: 347 PAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAW 395
                +  A+      + R     + + A +     +L  + +V   ++
Sbjct: 363 YFMNFIIMAMAAYFSAIVRAPITGIVLIAEMSGTLKMLLPIALVSFVSY 411


>UniRef50_B8FFG6 Chloride channel core n=2 Tax=Desulfobacteraceae RepID=B8FFG6_DESAA
          Length = 604

 Score =  100 bits (248), Expect = 1e-19,   Method: Composition-based stats.
 Identities = 60/334 (17%), Positives = 112/334 (33%), Gaps = 25/334 (7%)

Query: 2   LHPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPG-------------- 47
           L P+    +      VAIG+ + L  I+   +           L G              
Sbjct: 13  LDPKGAYAMKWVARFVAIGVVAGLGSILFHFLCEAGMRYFLDALAGYRPPAAAGESHRMF 72

Query: 48  TLGIAQDSPLWIIGVLTLTGIAVG-LVIRFSQGHAGP--DPACEPLI--GAPVPPSALPG 102
             G+ +     ++ +    GI  G LV  F+    G   D A +     G  +       
Sbjct: 73  EPGVKEPVRWMLLLLPAAGGIFSGWLVYTFAPESEGHGTDAAIDAYHNKGGFIRGRVPII 132

Query: 103 LIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFG 161
             +A  + L  G S G E PI  +       +  +L L    R           +G++F 
Sbjct: 133 KTLASAITLTTGGSGGREGPIAQIGAGFGSFLATKLKLSDRERRIMLAAGMGAGVGSIFR 192

Query: 162 TPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFH--PHFSLPIAHYGQME 219
            P+A AL  ++ L    ++   + +    ++A        L +     F  P+ ++   +
Sbjct: 193 APLAGALFAAEVLYRDPDIE-GEVVLPAGLSAVVAYCIFCLTYGWGSLFKAPV-NFVFRD 250

Query: 220 MTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVS 279
             ++L   I+A +  AAG V V     +     ++  P     + G +         P +
Sbjct: 251 PAELLPYTILALVVAAAGWVYVKSFYGVTGFFKRLALPNHFKPVLGGLCTGAIGFFFPQT 310

Query: 280 LFKGLDEMQ-QMVANQAFSTSDYFLLAVIKLAAL 312
           L  G   +Q  +  +   +     +LA  K+   
Sbjct: 311 LAFGYGYVQWAISGDPRATIPFLLILAFGKILTT 344


>UniRef50_B2A6J0 Chloride channel core n=1 Tax=Natranaerobius thermophilus
           JW/NM-WN-LF RepID=B2A6J0_NATTJ
          Length = 429

 Score = 99.8 bits (247), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 73/397 (18%), Positives = 147/397 (37%), Gaps = 20/397 (5%)

Query: 26  ILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRF---SQGHAG 82
           I+ V++ I   L  LL           ++  +  +    + GI +G V      S    G
Sbjct: 16  IVAVLVGILGGLSALLLNTAIDLFYFIRERYIHYLLGPVIAGIFLGFVFHKIDISTKSFG 75

Query: 83  PDPACEP--LIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARLLP 140
            +        +   +        + +  L L  G S G E P++ +  +++  +  R+ P
Sbjct: 76  TNVFINSVNRLNGAIKGRTSLFKLFSSSLNLGFGASGGIEGPMVLIGGSMSNFLLRRIKP 135

Query: 141 R------VNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAA 194
                   +    TI  +AG +GA+F +P+   +   + L        ++ LF  ++++A
Sbjct: 136 IAKYFSNEDMRIGTICGAAGAVGAVFRSPLGGGIFVVELL--YKSALHYNELFPAILSSA 193

Query: 195 AGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQM 254
            G +T  L         I  Y  ME+  I    + A +     +                
Sbjct: 194 IGYVTYSLVLDTDPLFTIPSYN-MEVQYIPFIVVTAVLTGIISIFFKIVFYGSREFFENS 252

Query: 255 KNPV-LVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALV 313
             P  L   +GG   G+  +I G   L  G + +Q+ +   + S     LL + K+ A  
Sbjct: 253 SIPQPLRPAVGGIFTGMTALIAGQEVLGIGTEYVQKFIL-TSMSIDIILLLLLGKIFATA 311

Query: 314 VAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLVVTRDGWLSLFM 373
               SG   G++ PA+++G   G ++   +    A   +  ++    +VV     LS   
Sbjct: 312 FTIGSGGSAGKVIPALYIGALAGSLVSSLLSFEFADSALHYSL----VVVGMTASLSAIA 367

Query: 374 AAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNRPK 410
              +     ++ +L + M  + ++ A    ++ N  +
Sbjct: 368 GVPIASVVMIIEMLGLKMGVSAVIGAVIGYIIGNNQQ 404


>UniRef50_A5TVM5 CIC chloride ion channel family chloride (Cl-):proton (H+)
           antiporter n=9 Tax=Fusobacterium RepID=A5TVM5_FUSNP
          Length = 521

 Score = 99.8 bits (247), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 60/402 (14%), Positives = 130/402 (32%), Gaps = 19/402 (4%)

Query: 12  LSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVG 71
           L    + +G+ +  I+         +                 S L +  +    G+ V 
Sbjct: 18  LYFACLLVGLITGAIVSAYRWALEEIGIFRSLYFSDINLNNPVSLLKMWLIFIAVGLIVN 77

Query: 72  LVIRFSQGHAGP-DPACEPLIGAPVPPSA----LPGLIVALILGLAGGVSLGPEHPIMTV 126
            + +     +G   P  + LI   +  +     L     A +LG+  G+SLG E P + +
Sbjct: 78  YLFKKFPKTSGSGIPQVKGLILGRINYNNWFFELLAKFFAGVLGIGAGLSLGREGPSVQL 137

Query: 127 NIALAVAIGARLLPRVNRMEWTIL-ASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDR 185
              +       L        + +   S+  +   FG P+A A+   + ++          
Sbjct: 138 GSYVGYGASKILKTDTVERNYLLTSGSSAGLAGAFGAPLAGAMFSIEEIHKYLS---GKL 194

Query: 186 LFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSG---AIVAAIAIAAGMVAVW 242
           L    +A+         FF    S  I     + +          I   I    G +   
Sbjct: 195 LICAFVASIGADFVGRRFFGVQTSFNIPIKYPLPINPYFQFALYIIFGVIIAFFGKLFTV 254

Query: 243 CLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYF 302
            L +   + + +K    +       +  +     P     G   ++ ++  +A   +   
Sbjct: 255 TLVKCQDLFNGVKLAREIKVSFIMTISFVLCFILPEVTGGGHSLVESLIHEKAVIYT-LI 313

Query: 303 LLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAIT------VSCAI 356
           ++ +IKL    ++ ++GF GG   P + +G  +G +  E V              +   +
Sbjct: 314 IIFIIKLLFTAISYSTGFAGGIFLPMLVLGAIIGKIFGETVDIFAQTGPDFTVHWIVLGM 373

Query: 357 LGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL 398
               + V R     + +   +  +  LL  L  V + ++ + 
Sbjct: 374 AAYFVAVVRAPITGVILILEMTGSFHLLLALTTVAVVSFYVT 415


>UniRef50_B2TNJ2 Voltage-gated chloride channel n=19 Tax=Firmicutes
           RepID=B2TNJ2_CLOBB
          Length = 457

 Score = 99.8 bits (247), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 56/357 (15%), Positives = 127/357 (35%), Gaps = 14/357 (3%)

Query: 58  WIIGVLTLTGIAVGLVI-RFSQGHAGPDPACEPLIG---APVPPSALPGLIVALILGLAG 113
           W++ +L + G  V  +  ++ +  +  +      I      +P      + +   +    
Sbjct: 65  WLLFLLPIGGAFVSFLYSKYGKSSSKGNNLIIDKINTNNGNIPMRMASLVFLGTFVTHLL 124

Query: 114 GVSLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQ 172
           G S G E   + +  +++  +G  L L +V+     +   +    ++FGTP+A  +   +
Sbjct: 125 GGSAGREGTGVQIGSSISEGVGRLLKLDKVDTKIILMCGISSGFSSVFGTPLAGTIFGLE 184

Query: 173 TLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAI 232
               +     +  L     +A  G + T  F   H    I     +    +L   I A +
Sbjct: 185 V--ATLGTMSYQALIPCFTSAFIGNIVTTAFGVHHSHYSILEVPTITYFVVLKIIIAAIL 242

Query: 233 AIAAGMVAVWCLPRLHAMMH-QMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMV 291
                 +      +L  +   + +N  +   +GGFI+ IL  + G          +   +
Sbjct: 243 FGLVSKLFSELTHKLKDIFSSRFENAAIKSMVGGFIIIILTYLIGTRD----YLGLSLPL 298

Query: 292 ANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAIT 351
            N +F+          KL        +GF+GG + P   +G   G  L   +   P+ + 
Sbjct: 299 INNSFTEQVSPFAFFNKLIFTSFTLGTGFQGGEVTPLFVIGSTFGNTLSNILHISPSFLA 358

Query: 352 VSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNR 408
            +  ++G+    T     S F+  + +     +  + +    ++L      + +  +
Sbjct: 359 -ALGLIGVFAGATNAPITS-FILGLELFGAQGIEFMFMTCAISYLFSGHSGIYISQK 413


>UniRef50_A8I3C7 Voltage gated chloride channel family protein n=3 Tax=Rhizobiales
           RepID=A8I3C7_AZOC5
          Length = 589

 Score = 99.5 bits (246), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 79/399 (19%), Positives = 146/399 (36%), Gaps = 20/399 (5%)

Query: 12  LSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVG 71
           L + A  IG+ + L + ++ + A +L ++L+      +      PL ++    + G+ +G
Sbjct: 33  LVVLAALIGVLAGLSVTLISRGAELLHSVLFGA--ARISSIPRLPLHVLLWPAIGGLIMG 90

Query: 72  LVIRFSQGHAGPDP----ACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVN 127
            VI   +               L G  +       L +  +L    G S+G E       
Sbjct: 91  GVILALKRWRPHSIVDPIEANALHGGRMSLPDSIILSLQTMLANGFGASVGMEAGYTQSG 150

Query: 128 IALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRL 186
             LA  IG  L L R++        +AG I A F  P+  A    + + G   +P     
Sbjct: 151 SGLASVIGQWLRLRRMDLRILVGCGAAGGIAAAFQAPLTGAFYGFELIIGVYAIP---AA 207

Query: 187 FAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPR 246
              + +A    LT          + +   G +E +  L   ++  IA    +  +  +  
Sbjct: 208 APVMTSALIAYLTARQLGAASTPIYVPEIGPLEPSAYLPFLLLGLIAGGVAIGIMRLVTL 267

Query: 247 LHAMMHQMKNPV-LVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLA 305
           +     +   P+ L   +GG  +G L     P  L  G   ++  V     S     LL 
Sbjct: 268 VERGFARSGLPLWLRPAVGGLGVGALA-YVSPQVLSSGEGALRIQVGTGITSAVALILL- 325

Query: 306 VIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAV------PAAITVSCAILGI 359
            +K+ A  ++  SGFRGG  F ++F+G  LG +      +V         I     +  +
Sbjct: 326 -LKVCASSLSLGSGFRGGLFFSSLFMGSLLGKLFAGLAGSVVPWLALDPVIAAVVGMSAL 384

Query: 360 VLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL 398
            + V    +   F+   +  +  +  L+    +   LL+
Sbjct: 385 AVGVVGGPFTMTFLTLEITGDLHIAGLVLTASIGCSLLV 423


>UniRef50_C7QDN8 Chloride channel core n=3 Tax=Actinomycetales RepID=C7QDN8_CATAD
          Length = 633

 Score = 99.5 bits (246), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 69/402 (17%), Positives = 138/402 (34%), Gaps = 13/402 (3%)

Query: 4   PRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVL 63
           PR   +  +++P    G  ++  L+ ++ + + +       L             I  + 
Sbjct: 54  PRVVVITAVAVPIGVCGALAAYALLKLITLVTNICFYAQFTLHSASPADTPHRWLIPILP 113

Query: 64  TLTGIAVGLVIRFSQG-----HAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLG 118
            + G+ VGL+ R+                  + G+ V P       ++  + +  G   G
Sbjct: 114 VVGGLVVGLMARYGSDKIRGHGMPEAIEAILIGGSKVQPRVAVLKPLSAAVSIGTGGPFG 173

Query: 119 PEHPIMTVNIALAVAIGARLLPRVN-RMEWTILASAGTIGALFGTPVAAALIFSQTLNGS 177
            E PI+    A+   +   L    + R    +  SA  + A F TP+AA ++  + L   
Sbjct: 174 AEGPIIMTGGAIGSLLAQVLHVTTDERKTLLVAGSAAGMAATFNTPLAAVVLAVELLLFE 233

Query: 178 SEVPLWDRLFAPLMAAAAGALTTG--LFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIA 235
                   L     AA    +  G  L + P F         +   D     +   +A  
Sbjct: 234 WR---PRSLIPVAAAAVTATIVRGPMLGYGPLFG-GAHVPAHLAFYDYPLCLVAGVVAGL 289

Query: 236 AGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQA 295
             + A   +        ++    +     G  +  +G +  P +L  G D +  ++  +A
Sbjct: 290 LAIGATALVYFSEDSFAKLPIHWMWWPAIGGAIVGVGGLIEPHALGVGYDVIDSLLTGRA 349

Query: 296 FSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCA 355
            +     +L V+K     ++  SG  GG + P   VG ALG       P+V        +
Sbjct: 350 TTGLIVGIL-VVKTLIWGLSLGSGTSGGVLAPMFMVGGALGAAEAMIFPSVSPGFWALVS 408

Query: 356 ILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLL 397
           + G++  V R     +     +      +  + +    A+L+
Sbjct: 409 LAGVLGGVMRSPLTGIVFCLELTHEVNAILPMIVTAGTAYLV 450


>UniRef50_D1U7C4 Chloride channel core n=2 Tax=Desulfovibrio RepID=D1U7C4_9DELT
          Length = 633

 Score = 99.5 bits (246), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 84/439 (19%), Positives = 142/439 (32%), Gaps = 43/439 (9%)

Query: 5   RARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLG------------IA 52
           R  T     +  V  GI S L+ +    +       +   L G +             + 
Sbjct: 19  RTVTSFRWLVIGVLAGILSGLVAVSFFWLVEAGTYFVQHFLAGIVSPEPAGEGIFHGPVG 78

Query: 53  QDSPLWIIGVLTLTGIAVG-LVIRFSQ-----GHAGPDPACEPLIGAPVPPSALPGLI-- 104
           +  P  I    T TG+  G LV RF       G  G D              A   +I  
Sbjct: 79  EFRPWVIPVFTTGTGLFTGWLVSRFIPETIAGGTDGTDATINAFHNQGGIIRARVAIIRG 138

Query: 105 VALILGLAGGVSLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTP 163
           +  +L +A G S G E PI  +       +          R    +  +AG +GA+F  P
Sbjct: 139 ICSVLTIASGGSAGREGPITQMGAGAGSWLAKIFDFSAKERRILLLAGAAGGLGAIFRAP 198

Query: 164 VAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDI 223
           +  AL   + +         + +   +M++         FF       I  +   +  ++
Sbjct: 199 LGGALTAVEVIYREDFEA--EAILPAVMSSVVSYSIFTFFFGTDPIFGIPRFTFHDPREL 256

Query: 224 LSGAIVAAIAIAAGMVAVWCLPRLH-AMMHQMKNPVLVL---GIGGFILGILGVIGGPV- 278
              A++A +  AAG + V     +   +   ++  + ++   GIGG  +G++G++     
Sbjct: 257 FFYALLALVCAAAGWMYVRTFHVIKYHIFFPLREKIGLIWSMGIGGLAMGLIGILYPHTA 316

Query: 279 --------SLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVF 330
                    L  G   ++  +  Q         L V K  A  V   SG  GG   PA+F
Sbjct: 317 TDGLITGGVLSGGYGWLELAMLGQ-IPALGMCYLIVGKTIATSVTIGSGMSGGMFAPALF 375

Query: 331 VGVA----LGLMLHEHVP--AVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLL 384
           VG      +G   H   P         +   +      V       L M   +     LL
Sbjct: 376 VGGMSGGLVGKFGHAFFPDIVTQPGAYILVGMAAFFAGVASAPIGPLIMVTELTQGYGLL 435

Query: 385 PLLCIVMLPAWLLLAGKPM 403
             L +      +L     +
Sbjct: 436 APLMLASALCLVLCRNVSL 454


>UniRef50_UPI0001C31F65 Cl- channel voltage-gated family protein n=1 Tax=Conexibacter
           woesei DSM 14684 RepID=UPI0001C31F65
          Length = 464

 Score = 99.5 bits (246), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 92/411 (22%), Positives = 165/411 (40%), Gaps = 21/411 (5%)

Query: 5   RARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSP-LWIIGVL 63
           R+R  + L L A  +GI  SL+    +++   +Q  L+  LP  +G    +P  W + +L
Sbjct: 21  RSRAFVALLLLAAVVGIVVSLLAWGFLELTHQIQVGLFTDLPKEVGYDDGAPLWWSLPIL 80

Query: 64  TLTGIAVGLVIRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPI 123
            + G+ V   I    G+ G  PA   L      P  LPG+++A +  +  GV LGPE P+
Sbjct: 81  LVAGVVVAFAIAKLPGNGGHVPA-NGLKMGLTEPIELPGVMLAALATIGLGVVLGPEAPL 139

Query: 124 MTVNIALAVAIGARLLPRVNRMEWTILASAGTIGA---LFGTPVAAALIFSQTLNGSSEV 180
           + +   L V    +L          ++A++GT  A   LF +P+ AA+I  +        
Sbjct: 140 IALGGGLGVLFLRQLRRDAPSEVALVMAASGTFAAVSLLFESPLIAAVILIEASGLGGPR 199

Query: 181 PLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDI----LSGAIVAAIAIAA 236
                L   L A     ++ G+      S        +E+        +    + +   A
Sbjct: 200 LPVVLLPGLLAAGIGSLVSIGMGSWTGLSTSAYALSALELPQYARPTAAALGWSILLAVA 259

Query: 237 GMVAVWCLPRLHAMMHQMK--NPVLVLGIGGFILGILGVIGGPVS-------LFKGLDEM 287
             V    + R   ++ ++      +V  + G ++G L +     +       LF G D +
Sbjct: 260 VTVGAVAIVRAGRVVARISDGRAFVVAPLAGLLIGGLAIAFASTTDKDVAQVLFDGQDSI 319

Query: 288 QQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVP 347
             M A+ A  +     L V    A    +   FRGG  FPA+ +G A G+M    +P   
Sbjct: 320 GPMTASPAAWSLGTLALLVAFKGAAWSLSLGAFRGGPTFPALLLGAAAGMMAAR-LPGFD 378

Query: 348 AAITVSCAILGIVLVVTRDG--WLSLFMAAVVVPNTTLLPLLCIVMLPAWL 396
               ++  +   ++ V R     ++L +           PL+ + ++ A+L
Sbjct: 379 LTPAIAVGMAAAIVAVLRLPLSAVALAVLLTAGAGAGAAPLIIVGVVVAYL 429


>UniRef50_D1RX40 Chloride channel protein n=1 Tax=Serratia odorifera 4Rx13
           RepID=D1RX40_SEROD
          Length = 517

 Score = 99.1 bits (245), Expect = 3e-19,   Method: Composition-based stats.
 Identities = 72/397 (18%), Positives = 139/397 (35%), Gaps = 25/397 (6%)

Query: 5   RARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLT 64
           R +T + +   A  +G  + L+ +   K    +Q      L           +W +  + 
Sbjct: 66  RDKTPVAILFMAAVVGTLAGLLGVAFDKAVDWVQQQRLSALAQVA--DSWILVWPLAFIL 123

Query: 65  LTGIAVG---LVIRFSQGHAGP-DPACEPLIGAPVPPS---ALPGLIVALILGLAGGVSL 117
              +AV    LV RF+    G   P  E  +    P      +P   +  +  L  G+ L
Sbjct: 124 SAALAVLGYYLVRRFAPEAGGSGIPEIEGALEELRPVRWWRVIPVKFIGGMGTLGAGMVL 183

Query: 118 GPEHPIMTVNIALAVAIGA--RLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLN 175
           G E P + +   +   +    R+     R       +A  + A F  P+A  L   + + 
Sbjct: 184 GREGPTVQMGGNVGRMVLDIFRMRGAEARHSLLATGAAAGLSAAFNAPLAGILFIIEEMR 243

Query: 176 GSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIA 235
                 L   + A  +     ++   LF   H  + +       +  +    ++ A+  A
Sbjct: 244 PQFRYNLIS-IKAVFIGVIMSSVVFQLFNGEHSVIEVGKLSSAPINTLWLYLVLGAVFGA 302

Query: 236 AGMVAVWCLPRLHAMMHQM-----KNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQM 290
            G++    + R   M  +      +N +++ G+ G   GILG+I  P +   G   +  +
Sbjct: 303 VGVMFNALIFRTQDMFARFHGGKMRNILMIGGLIGGTCGILGLI-QPQAAGGGFGLIP-I 360

Query: 291 VANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAI 350
            A   +S      + + ++   ++   SG  GG   P + +G   G         +    
Sbjct: 361 AAAGNYSVGMLLFIFIARVITTLLCFGSGAPGGIFAPMLALGTLFGTAFGLAGAHLFPQY 420

Query: 351 TVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLL 387
            +      I       G  +LF A V  P T ++ +L
Sbjct: 421 GIEAGTFAI------AGMGALFAATVRAPLTGIVLVL 451


>UniRef50_C7M702 Chloride channel core n=15 Tax=Bacteroidetes RepID=C7M702_CAPOD
          Length = 598

 Score = 99.1 bits (245), Expect = 3e-19,   Method: Composition-based stats.
 Identities = 70/393 (17%), Positives = 139/393 (35%), Gaps = 39/393 (9%)

Query: 22  ASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRFSQGH- 80
           A+ L  + +     ++Q LL  +L  T+  +     +I+ +L      V LV ++   H 
Sbjct: 37  ATGLAALAMRSFTHLIQWLLDDKLAQTITYSF---YFILPMLGFA--IVYLVKKYVIRHD 91

Query: 81  ----AGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGA 136
                             +      G I+   + +  G S+G E P++     ++  I  
Sbjct: 92  VNHGIPSILYAVAHQKGIMKRFQAYGSILTAPITVGFGGSVGLEGPMVVTGAGISSNICR 151

Query: 137 RLL-PRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAA 195
                + NRM     A A  + A+F  P+AA L   +       +     L    +A+  
Sbjct: 152 FFHINQSNRMLLLACACAAALAAIFKVPIAAILFAIEVFGLDLTL---SSLIPLFIASLC 208

Query: 196 GALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMK 255
           G  T+  FF     +PI       +  I    ++  +         +   +++A   ++ 
Sbjct: 209 GVFTSYFFFGSEVLIPITITRAFSLQGIPFYILLGVVGGLMSAYFTYVYEKINATFKKLT 268

Query: 256 NPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQM-----------------VANQAFST 298
           +P L + +GG +LG+L +   P    +G + +  +                 ++N     
Sbjct: 269 SPWLKIVVGGALLGLL-IYIMPPLYGEGHEIINHLKEGHPELSLSSNIFGWDLSNAWVII 327

Query: 299 SDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVS----- 353
                L   K+ A  +   +G  GG   P +F+G  +G  L   +   P     +     
Sbjct: 328 LLLAALTFAKVIATSLTFGAGGVGGIFSPMLFMGGVMGNCLARIINEFPILGYKAELPNF 387

Query: 354 --CAILGIVLVVTRDGWLSLFMAAVVVPNTTLL 384
               +  ++  V      ++F+ A V    +LL
Sbjct: 388 TLVGMTALMTGVLHAPLTAVFLIAEVTGGYSLL 420


>UniRef50_C0QQU7 Chloride channel protein n=1 Tax=Persephonella marina EX-H1
           RepID=C0QQU7_PERMH
          Length = 586

 Score = 99.1 bits (245), Expect = 3e-19,   Method: Composition-based stats.
 Identities = 74/416 (17%), Positives = 150/416 (36%), Gaps = 36/416 (8%)

Query: 17  VAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSP----------------LWII 60
           V IG+ + L  I+ +K   +  +     L G +     SP                  + 
Sbjct: 19  VLIGLFAGLFAIIFLKAIKISSDFF---LGGIVSYQPPSPFGEGGSHFFSFEMERAYLLP 75

Query: 61  GVLTLTGIAVGLVIRF---SQGHAGPDPACEPLIGAPVPPSALPGL-IVALILGLAGGVS 116
               L G+ VG+++          G D A                + ++   + +  G  
Sbjct: 76  ISTALGGLIVGILVYLFSPESAGVGTDAAIRAFHHRKYLGLKTSIMKLITAAVTIGSGGV 135

Query: 117 LGPEHPIMTVNIALAVAIGARLLPRVNRMEWTIL-ASAGTIGALFGTPVAAALIFSQTLN 175
            G E PI  +   +   +G          +  +       I  +F  P A A+I S+   
Sbjct: 136 SGKEGPIALIGAGIGSFLGRIFKLSDREKDIALAVGMGAGIAGVFKAPFAGAIISSEVFY 195

Query: 176 GSSEVPLWDRLFAPLMAAAAGALTTG--LFFHPHFSLPIAHYGQMEMTDILSGAIVAAIA 233
                   + L    +A+    +  G  L F P F + +  +  + + D  +   +    
Sbjct: 196 KKDFET--ETLIPSFIASFIAFIVVGSFLGFSPLFHIELPQFNGLSVNDAAAYIFLGIST 253

Query: 234 IAAGMVAVWCLPRLHAMMHQMK-NPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVA 292
                + ++ L +   + + +  +PV    +GGF +G++G+   PV++  G   +Q +++
Sbjct: 254 AMIARLMIFSLDKSREIFNSLGIHPVFKPAVGGFFVGLMGMFT-PVAIGTGYGWLQMIMS 312

Query: 293 NQAFSTSDYFLLA--VIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAI 350
                 S   ++    + + A      SG  GG   P++ +G   G  ++  + A+    
Sbjct: 313 GNLVYLSPLLIVVSIFVVILAFSFTLGSGGSGGVFGPSLVIGGLTGASVYYLLSAIGFQE 372

Query: 351 TVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMV 406
           + S  I  + +V    G +S F AA   P +TL+ +  I      L+ A   + + 
Sbjct: 373 SSSFNITALTVV----GMVSTFAAAAKAPLSTLILVAEITGGYQLLVPAIIAVAIS 424


>UniRef50_Q73KN8 Voltage-gated chloride channel n=2 Tax=Treponema RepID=Q73KN8_TREDE
          Length = 528

 Score = 99.1 bits (245), Expect = 3e-19,   Method: Composition-based stats.
 Identities = 71/403 (17%), Positives = 144/403 (35%), Gaps = 18/403 (4%)

Query: 8   TMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPL---WIIGVLT 64
             L+++  +  +GI + L +    K    L +L        +     +      +I  +T
Sbjct: 18  NHLIITGESFIVGILTGLAITAFRKSIDFLSSLRIDVYDKAVSGQFGTVFGFGVLILAVT 77

Query: 65  LTGIAVGLVIRFSQGHAGP-DPACEPLIGAPV---PPSALPGLIVALILGLAGGVSLGPE 120
           + G+ +G +I+      G      +      +   P   LP   +  +L ++ G+S+G E
Sbjct: 78  VLGLFMGFIIKKYPMIKGSGVSQIKGKFMKKLDMSPWPELPLKFLGGVLNISAGLSVGRE 137

Query: 121 HPIMTVNIALAVAIGARLLPR-VNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSE 179
            P + +   +  A         + R+      +A  + A FG P A  +   + L+    
Sbjct: 138 GPSVQIGAYIGSAFEKIGKTSHIERVCLVTSGAAAGLAATFGAPFAGIVFAIEDLHQYLS 197

Query: 180 VPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMV 239
                 L   ++ A AG L T LFF               +       ++ A A   G +
Sbjct: 198 ---PLLLTCVMLGAFAGDLATSLFFKQGAIFDFHGLQLFPIKYFGWLILMGAAAALIGHL 254

Query: 240 AVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTS 299
               +     M  ++K P     +  +++ +   I  P++   G D + + +A  +F  S
Sbjct: 255 FKKSIYTSQKMYRKLKIPPQFSPLIPYLISVPVCIFLPLAA-SGGDHLIEAIAEHSFPLS 313

Query: 300 DYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLH------EHVPAVPAAITVS 353
              L+   K+    ++A SG  GG   P +  G   G++          + A  A   + 
Sbjct: 314 MLVLILAAKIIFTGLSAGSGAIGGIFVPLLSCGALTGIIFSNILVYFNLIEAQYAVNLMV 373

Query: 354 CAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWL 396
            A+      V +    ++ + A    +   L  L +    A++
Sbjct: 374 FAMAAFFTTVIKAPITAIVLLAETSGDLFHLGGLVLTTAAAYI 416


>UniRef50_A5FBK4 Cl-channel, voltage-gated family protein n=4 Tax=Flavobacteriales
           RepID=A5FBK4_FLAJ1
          Length = 598

 Score = 99.1 bits (245), Expect = 3e-19,   Method: Composition-based stats.
 Identities = 76/414 (18%), Positives = 146/414 (35%), Gaps = 30/414 (7%)

Query: 12  LSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVG 71
           + L +V IGI ++  +I +   A  + +     +   + ++  + +  +  + LT + V 
Sbjct: 29  IFLSSVLIGIIAAFAVIFLKAFAHWVFSFA-AYINAIVKLSFINSILPLIGILLTVLVVN 87

Query: 72  LVIRFSQ-GHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIAL 130
            ++  S                + +P   +   I+   L +  G S G E PI+    A 
Sbjct: 88  RILGGSLEKGTSQILYIVARKASIIPKKQMYAQIMTSSLTVGLGGSAGLESPIVITGAAF 147

Query: 131 AVAIGARLLPRVNRMEWTI-LASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAP 189
                 +           I    A  I A F  P+A  L   + L     +  +      
Sbjct: 148 GSNFAQQFKLSYQERTLLIGCGVAAGIAAAFNAPIAGVLFAVEVLLVDVTIAAFT---PI 204

Query: 190 LMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAV-WCLPRLH 248
           ++AAA GAL + +  + +  L        +  +I    ++        +      L   H
Sbjct: 205 MIAAATGALVSAVVLNENILLVFREKQTFDYHNIPFYVLLGLFTGLTAVFYARKFLKTEH 264

Query: 249 AMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQ-----------AFS 297
              H    P     IGG +LGIL +   P    +G + ++ +                +S
Sbjct: 265 FFAHLKFGPYKKALIGGAVLGIL-IFVFPTLFGEGYESIKILADKNPGALLKNTLFEQYS 323

Query: 298 TSDYFLLAVI------KLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPA-----V 346
            S + LLA +      K  A  +   SG  GG   P++F+G   G    + +       +
Sbjct: 324 DSSWILLAFVGFSMFLKAFASGITLGSGGNGGNFAPSLFLGSYAGYFFSKLLNLAGLTDL 383

Query: 347 PAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAG 400
           P +      + GI+  +      ++F+ A +     L+  L IV   ++ +  G
Sbjct: 384 PISNFTLVGMAGILSGLFHAPLTAIFLIAEITGGYDLMIPLMIVASVSFAVSKG 437


>UniRef50_Q1MXQ9 Chloride channel protein EriC n=1 Tax=Bermanella marisrubri
           RepID=Q1MXQ9_9GAMM
          Length = 584

 Score = 98.7 bits (244), Expect = 3e-19,   Method: Composition-based stats.
 Identities = 70/412 (16%), Positives = 135/412 (32%), Gaps = 28/412 (6%)

Query: 17  VAIGIASSL-----ILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVG 71
             +GI + L     IL+  + I   L   L   +P        +PL  + +  +  + + 
Sbjct: 22  AMLGIVAGLLTSGIILLFRLAIEHSLSGFL--GMPHHEAFEALNPLVRMTLPMMGALLLI 79

Query: 72  LVIRFS-----QGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTV 126
            +         Q                +P S L       I+    G S G E P + +
Sbjct: 80  ALFYKVSAKARQVGISHVLERLKNHQGHMPMSNLFVQFFGGIICAISGQSTGREGPAVHL 139

Query: 127 NIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQ-TLNGSSEVPLWD 184
             A    +  +L +   +         A  I A F TP+A  +   +  + G S +    
Sbjct: 140 GAAAGSIMSRKLQMTSSHTQLLLACGVAAAISASFNTPIAGVIFAMEVIVMGYSFLS--- 196

Query: 185 RLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCL 244
            L   ++A+  GAL T   +    S P  +   ++M  +L    +    +  G +A   +
Sbjct: 197 -LIPVILASVTGALVTRAVYG---SEPAFNVPALQMNSLLEAPFLIVEGLLMGALAAMFI 252

Query: 245 PRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLL 304
                   +      +  +   +L  +  +  P  +  G D +   +          F+ 
Sbjct: 253 WVCVNTAKKAPQSFTIRLLLIGVLNGVLALLIPAVMGIGYDTVNAALLGN-LPWIALFIF 311

Query: 305 AVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVS------CAILG 358
           A+ KL    +    G  GG I P +F+G   G ++ E        I  S        +  
Sbjct: 312 AMAKLLITSLNLGLGQPGGAIGPMLFIGACAGGVIGEIGNQFAPDIAGSTGYYAMLGMAA 371

Query: 359 IVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNRPK 410
           ++    +    +L     +  N  +L    +V++ A L  +         P+
Sbjct: 372 MMSACLQAPLTALMTLLELTNNPNILLPAMLVVVIANLTASEIFKQKALFPR 423


>UniRef50_D2QXG0 Chloride channel core n=1 Tax=Pirellula staleyi DSM 6068
           RepID=D2QXG0_9PLAN
          Length = 459

 Score = 98.7 bits (244), Expect = 4e-19,   Method: Composition-based stats.
 Identities = 80/385 (20%), Positives = 136/385 (35%), Gaps = 36/385 (9%)

Query: 12  LSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVG 71
           LSL A  IG+ + L +   +                   + +    W+I ++ L G+ V 
Sbjct: 21  LSLAATVIGVVTGLAVAFFL------------WSLDQATLLRYEHPWLIYLMPLAGVLVA 68

Query: 72  LVIRFS--QGHAGPDPACEPLIG--APVPPSALPGLIVALILGLAGGVSLGPEHPIMTVN 127
           L  +    Q  AG +   E +    A VP    P +++  +     G S G E   + + 
Sbjct: 69  LAYQRLCPQAEAGNNLLLEEIHEPAAGVPLWMAPLVLLGTLATHVTGGSAGREGTAVQMG 128

Query: 128 IALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRL 186
            +LA ++G  L + R  +  + +   A   GA+FGTPVA A+   + L        +   
Sbjct: 129 GSLAHSVGQWLGIERSEQRTFLMAGMAAGFGAVFGTPVAGAIFAIEVLTHGQLS--YRGF 186

Query: 187 FAPLMAAAAGALTTGLFFHPHFSLPI---------AHYGQMEMTDILSGAIVAAIAIAAG 237
              L+A+  G  TT L    H    I         +H G +++  +L   I A       
Sbjct: 187 LTCLLASIVGDTTTTLCGIGHTEYKIAPWMSAAAGSHLGPLDLVLLLKIVIAAVAFGLMA 246

Query: 238 MVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFS 297
            +      R  A++ +     L     G  + +L         + GL  M         +
Sbjct: 247 RLFAELTHRTSALLKRYVPWSLARPAIGAAVVLLLTAIVASRDYLGLGVMPDPHDPSLMT 306

Query: 298 TSDYFLLAVI-------KLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAI 350
            +  F            K     V   SGF+GG + P  F+G A G  +   + A P  +
Sbjct: 307 IAGCFEEGGAGPMSWAWKTVFTAVTVGSGFKGGEVTPLFFIGAAGGNAMGTLLSA-PLGL 365

Query: 351 TVSCAILGIVLVVTRDGWLSLFMAA 375
             +   + +    T+    S  M  
Sbjct: 366 LAAVGFVSLFAAATKTPLASTLMGI 390


>UniRef50_B2HXI5 Chloride channel protein EriC n=11 Tax=Acinetobacter
           RepID=B2HXI5_ACIBC
          Length = 406

 Score = 98.3 bits (243), Expect = 4e-19,   Method: Composition-based stats.
 Identities = 62/332 (18%), Positives = 117/332 (35%), Gaps = 23/332 (6%)

Query: 56  PLWIIGVLTLTGIAVGLVIRF--SQGHAGPDPACEPLIGAP---VPPSALPGLIVALILG 110
             W+I  L   G  +G +I+   S    G        I  P   +P    P + +  IL 
Sbjct: 51  HHWLIYFLPFVGFGIGYLIKKYGSPIERGTHL-LIDEIHQPKSFIPKRMSPIIFITSILT 109

Query: 111 LAGGVSLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALI 169
              G S G E P + ++ AL   +   L +   NR    I +       +FG P+A A+ 
Sbjct: 110 QLFGGSAGREAPAVQLSGALIDHLSHILKISEDNRKICLIASIGAGFAGVFGLPLAGAIY 169

Query: 170 FSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLF------FHPHFSLPIAHYGQMEMTDI 223
             +         L +  ++ +      AL            HPH    I+ +  +    +
Sbjct: 170 GLEI------TALGNLRYSAIFPCFVSALIASAIPELFEIVHPHVFYVISEFPAIHFGTL 223

Query: 224 LSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKG 283
           +S      I        +  +     + ++    + +  + G I+ +L  +      + G
Sbjct: 224 MSLIAAGLIFGLVARFFIAAIHFASDVFYKYVRYLPLRTMAGGIVIMLLTLFTAHQQYNG 283

Query: 284 LDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHV 343
           L   + +    +F     F     K     +   SGF+GG I P  +VG  LG  L   +
Sbjct: 284 LGTDKII---SSFYVPIEFYDFFNKTIFTAITLGSGFKGGEITPLFYVGATLGNALGAVL 340

Query: 344 PAVPAAITVSCAILGIVLVVTRDGWLSLFMAA 375
             +P ++     ++ +    ++    S+ +A 
Sbjct: 341 -NLPISLLAGLGLVSLFSGASKAPLTSIILAV 371


>UniRef50_UPI0001BC5534 chloride channel protein n=3 Tax=Fusobacterium RepID=UPI0001BC5534
          Length = 526

 Score = 98.3 bits (243), Expect = 5e-19,   Method: Composition-based stats.
 Identities = 66/404 (16%), Positives = 135/404 (33%), Gaps = 21/404 (5%)

Query: 12  LSLPAVAIGIASSLILIVVMKIASV--LQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIA 69
           L    + +G+ + +I+        +  +    +              LWI G L +    
Sbjct: 22  LYFLCLMVGLITGIIVSFYRYALHIFNVLRETFVSPNTLTNYPFLIKLWI-GFLVIGFFI 80

Query: 70  VGLVIRFSQGHAGPDPACEPLIGAPVPPS----ALPGLIVALILGLAGGVSLGPEHPIMT 125
             L  ++ +      P  + +I   V        L    V  + G+  G+SLG E P + 
Sbjct: 81  DFLYRKYPRTSGSGIPQVKGIILGTVHYKHWFAQLVAKFVGGLFGIGAGLSLGREGPSVQ 140

Query: 126 VNIALAVAIGARLL-PRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWD 184
           +   +A  I       RV+        ++  +   FG P+A  +   + L+      L  
Sbjct: 141 LGSYVASGIAKGFRCNRVDENYLITSGASAGLAGAFGAPLAGVMFSLEELHKFLTAKL-- 198

Query: 185 RLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSG---AIVAAIAIAAGMVAV 241
            +    +A+ A       FF    +  +      ++   L      +   +    G +  
Sbjct: 199 -IICIFVASIASDFIGRRFFGIDTAFSMLVSYPRDINPYLQFALYILFGILIAFFGKLFT 257

Query: 242 WCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDY 301
             L +   +   ++    +  +       L  +  P     G + ++ +   Q       
Sbjct: 258 TTLVKTQNIFQGIRISRWMKVVFVMSTSFLLCLVLPEVTGGGHELVESLPQLQ-QGILFL 316

Query: 302 FLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHV----PAVPAAIT--VSCA 355
           F + +IKL    ++ A+GF GG   P + +G  LG +    +    P  P  I   +   
Sbjct: 317 FFVFLIKLLFTSLSYATGFAGGIFLPMLVLGAILGKIFALLLLHFFPFDPNIIVHFMVLG 376

Query: 356 ILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLA 399
           ++G  + V R       +   +  +   L  L  V + A+ + A
Sbjct: 377 MVGYFVSVVRAPITGAVLILEMTGSFDHLLALVTVSVVAFYVTA 420


>UniRef50_B0MW79 Putative uncharacterized protein n=1 Tax=Alistipes putredinis DSM
           17216 RepID=B0MW79_9BACT
          Length = 603

 Score = 97.9 bits (242), Expect = 6e-19,   Method: Composition-based stats.
 Identities = 70/418 (16%), Positives = 137/418 (32%), Gaps = 27/418 (6%)

Query: 2   LHPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIG 61
           L  R  +  +++L A+ +G+ + L   +   +   ++  L    P           + + 
Sbjct: 24  LTKRFTSTQIMALLAIIVGVLAGLGTCLFELLLYGIKAGLTHWFPVEQS-HFLFLFYPVI 82

Query: 62  VLTLTGIAVGLVIRFSQGHAGP-DPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPE 120
            + L  + V  V++ +                + +        +V     +  G S+GPE
Sbjct: 83  GIILASLFVKYVVKDNISEGVTRVLYAMSRKNSYIASHNCWTSVVGGATTIGFGGSVGPE 142

Query: 121 HPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSE 179
            PI+    A+   I     L   N        +   + A+F  P+   +   + L     
Sbjct: 143 APIVLTGAAIGSNISRLAHLNYKNTTLLLCCGAGAALAAIFKAPITGVVFVLEILMLDLT 202

Query: 180 VPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMV 239
                 L    + AAA ALT    F P  ++ +       +  I    ++          
Sbjct: 203 SRTVVPLLISSITAAAVALTIR-GFDPIIAISLTPDDAFRLNQIPLFVLLGIFCGLMSYY 261

Query: 240 AVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFS-- 297
                 R+ A   ++ +P     IGG +LGIL +   P    +G +    ++        
Sbjct: 262 FTTVNARVGAFFKKIDSPYKKWLIGGAVLGIL-IYIFPPLYGEGYEGFMSLMHGNTTELF 320

Query: 298 -------------TSDYFLLA--VIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEH 342
                            F++     K+ A+    A+G  GG   P++FVG  +G +    
Sbjct: 321 NNSLFYRFSQIDWVVILFIVGTMFFKVIAMASTNAAGGVGGTFAPSLFVGAFMGAITALV 380

Query: 343 VP-----AVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAW 395
                   +         + G++  V +    S+F+ A +     L   L I    A+
Sbjct: 381 CNTLFGWNLSLVSFTLVGMAGVMSGVMKAPLTSIFLIAELSSGYGLFIPLMITACIAF 438


>UniRef50_D1AXX8 Chloride channel core n=1 Tax=Streptobacillus moniliformis DSM
           12112 RepID=D1AXX8_STRM9
          Length = 538

 Score = 97.9 bits (242), Expect = 6e-19,   Method: Composition-based stats.
 Identities = 53/332 (15%), Positives = 111/332 (33%), Gaps = 21/332 (6%)

Query: 84  DPACEPLIGAPVPPSALPGLI---VALILGLAGGVSLGPEHPIMTVNIALAVAIGA-RLL 139
            P    LI   V  + LP LI    + +L +  G SLG E P + +   +   +      
Sbjct: 95  IPQVMGLIQKKVKFNWLPELITKFFSGLLAIFIGFSLGREGPSIHLGSLVGQGVNEISKR 154

Query: 140 PRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALT 199
             V +       ++  + A F  P++ A IF+         P+   L   L+A+    L 
Sbjct: 155 TEVEKKYLITCGASAGLAAAFNAPLSGA-IFAIEELHKFFSPIL--LICVLIASLFANLI 211

Query: 200 TGLFFHPHFSLPIAHYGQ---MEMTDILSGAIVA----AIAIAAGMVAVWCLPRLHAMMH 252
           +        S     +      E+ +I+   I+      + I    +  + + +   +  
Sbjct: 212 SKFLLGTQLSFESFSFISPINFELKEIIIHLILISILCFVIILLASIFNYSIIKFKDIYS 271

Query: 253 QMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAAL 312
            ++           +  +L V   P     G   ++ ++   + +     L+ V K    
Sbjct: 272 NIRLSKYTKISIVALFSLLVVYFLPEITGGGHHIIEHLLEYNS-TFRLLGLILVGKFLFT 330

Query: 313 VVAAASGFRGGRIFPAVFVGVALGLMLHEHV------PAVPAAITVSCAILGIVLVVTRD 366
           +++ ++G  GG   P + +G  +G +    +            + V  A+      V R 
Sbjct: 331 MISYSTGAPGGIFLPLLVIGALVGKIYGIFLVNTFNFTEEYMTLFVLIAMTSYFTAVVRT 390

Query: 367 GWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL 398
               + +   +  N + L  L I     +   
Sbjct: 391 PITGIILILEMTGNFSNLFSLVIASTITYAFT 422


>UniRef50_C8X5N8 Cl-channel voltage-gated family protein n=1 Tax=Desulfohalobium
           retbaense DSM 5692 RepID=C8X5N8_DESRD
          Length = 605

 Score = 97.5 bits (241), Expect = 7e-19,   Method: Composition-based stats.
 Identities = 65/315 (20%), Positives = 113/315 (35%), Gaps = 21/315 (6%)

Query: 17  VAIGIASSLILIVVMKIASVLQNLLWQRLPG----------TLGIAQDSPL--WIIGVLT 64
           + IG+ + L  I+   +  +  +     L G           L    D+P   WI+  L 
Sbjct: 31  ILIGVIAGLGSILFHTLCELGMHFFLDGLAGYRPPVPAGEHALLPPTDTPFSRWILLFLP 90

Query: 65  -LTGIAVG-LVIRFSQGHAGP--DPACEPLI--GAPVPPSALPGLIVALILGLAGGVSLG 118
            L G+  G LV  ++    G   D A +     G  +         VA  + L  G S G
Sbjct: 91  ALGGLVSGWLVYTYAPEAEGHGTDSAIDAYHNKGGQIRGRVPIIKTVASAITLTTGGSGG 150

Query: 119 PEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGS 177
            E PI  +       +G +L L    R        A  +G++F  P+A AL  ++ L   
Sbjct: 151 REGPIAQIGAGFGSFLGNQLGLSERERRIMLAAGVAAGVGSIFRAPMAGALFAAEVLYRE 210

Query: 178 SEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAG 237
            E    + +    +A+A       L +         ++      ++   A++A +  A G
Sbjct: 211 PEFE-SEVIIPAGIASAVAYCIFCLVYGWGSLFHAPNFTFTNPLELGPYALLALVLTAGG 269

Query: 238 MVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFS 297
            V V C   +HA+  ++          G +L        P +L  G   +QQ + N    
Sbjct: 270 FVYVKCFHGVHALFAKIPIKNHFKPAIGGLLTGGIGFFLPQTLAFGYGVVQQAI-NGELG 328

Query: 298 TSDYFLLAVIKLAAL 312
            +    +A+ K+   
Sbjct: 329 IALLLGVALGKILTT 343


>UniRef50_Q189E6 Chloride ion channel protein n=10 Tax=Bacteria RepID=Q189E6_CLOD6
          Length = 524

 Score = 97.5 bits (241), Expect = 7e-19,   Method: Composition-based stats.
 Identities = 65/400 (16%), Positives = 139/400 (34%), Gaps = 15/400 (3%)

Query: 9   MLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGI 68
            ++L    + +G  + LI+++   +       L Q L    G       W   +  L  I
Sbjct: 16  QVILIGEGLMVGAVAGLIVLLYRILLGQAGTWLSQILKFVEGSTIKIIAWFAVLAVLAWI 75

Query: 69  AVGLVIRFSQGHAGPDPACEPLIGAPVP---PSALPGLIVALILGLAGGVSLGPEHPIMT 125
              LV           P  E  +   +       LP   +   L L GG++LG E P + 
Sbjct: 76  VSKLVDWEPMISGSGIPQLEGEMTGKIKQVWWRVLPTKFIGGFLSLMGGLALGREGPSIQ 135

Query: 126 VNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWD 184
           +       I   L   +          ++  + A F  P+A  +   + ++ +  V +  
Sbjct: 136 LGAMAGKGISRALDRGKTEEKFLLTCGASAGLSAAFHAPLAGVMFSLEEVHKNFSVSVLI 195

Query: 185 RLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCL 244
            +    + A        L     F   I +    +   ++   I+  I    G    W  
Sbjct: 196 SVMTASLTADY-ISANFLGMESVFQFDIGNVLPQDYYGLI--VILGVILGVMGAFYNWFT 252

Query: 245 PRLHAMMHQMKNPVLV-LGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFL 303
             + ++  ++         +  FI+  +  I  P  L  G + ++++ +++        +
Sbjct: 253 LYVQSLYKKIPKIGTFGKLLIPFIMAGILGIVMPDVLGSGHNLVEELTSHEYIFGMVVLI 312

Query: 304 LAVIKLAALVVAAASGFRGGRIFPAV----FVGVALGLMLHEHVPAVPAAIT--VSCAIL 357
             VI+     V+  SG  GG  FP +    F+G   G++  +     P  +   V  A+ 
Sbjct: 313 F-VIRFIFSAVSFGSGAPGGIFFPLLVLGAFIGGIFGMVGVKVFGMNPDYVNNFVLLAMA 371

Query: 358 GIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLL 397
           G    + R     + +   +  + + +  L ++ + A+++
Sbjct: 372 GYFTAIVRAPLTGIILIFEMTGSVSQMLSLSVISIVAYIV 411


>UniRef50_D2QHH8 Cl-channel voltage-gated family protein n=1 Tax=Spirosoma linguale
           DSM 74 RepID=D2QHH8_9SPHI
          Length = 452

 Score = 97.5 bits (241), Expect = 9e-19,   Method: Composition-based stats.
 Identities = 64/395 (16%), Positives = 133/395 (33%), Gaps = 19/395 (4%)

Query: 16  AVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIR 75
           A  IG    ++    +     +               Q    W+     +  +    V++
Sbjct: 20  ASLIGCVVGVVASGFILSLHYIIE--------QSNQYQHIFYWLPVSFFVANLLSQFVLK 71

Query: 76  FSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIG 135
              G      A     G  +  S +P  +V ++L LA G S G E P   +   +     
Sbjct: 72  RHLGTDALIDAINKNYG-KLEGSFIPTKVVNVVLILATGGSAGKESPCAQIGAGIGSVCA 130

Query: 136 ARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAA 194
               +  ++R +  +         +FG P+A AL   + L  +  V ++D L    +A+ 
Sbjct: 131 NLFRVDDIDRRKMVLCGFCAGFACVFGAPMAGALFGIEVL--AVGVIVYDVLLPAFVASV 188

Query: 195 AGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQM 254
                + +     F  P+           +                V  + +     + +
Sbjct: 189 TAYQVSSVLGVTFFYYPLTFIPAFGQGFFIQLLAGGIFFGLCAYALVRAIQQSTQATNAI 248

Query: 255 KN-PVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALV 313
                L   +GG IL  L ++     L  GL+ M+  +     S   + L A+  +  L 
Sbjct: 249 PLWRPLKGLLGGIILVGLTLLFSRDYLGLGLNLMEDCIKGIHVSGYAFLLKALFTIITLS 308

Query: 314 VAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLVVTRDGWLSLFM 373
           ++ +    G  I P +F+G   G    + V A  +       +   +L  T +  ++  M
Sbjct: 309 ISRS----GSVITPVLFIGATAGSFFSQLVGADQSTFAAIGFVS--LLAGTTNTPIATSM 362

Query: 374 AAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNR 408
            A+ +   ++ P   +  + ++L+   + +    R
Sbjct: 363 LAIELFGASVAPYAAVSCVLSYLMSGHQSLYASQR 397


>UniRef50_Q1IME9 Cl-channel, voltage gated n=1 Tax=Candidatus Koribacter versatilis
           Ellin345 RepID=Q1IME9_ACIBL
          Length = 613

 Score = 97.5 bits (241), Expect = 9e-19,   Method: Composition-based stats.
 Identities = 61/360 (16%), Positives = 121/360 (33%), Gaps = 13/360 (3%)

Query: 11  LLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSP---LWIIGVLTLTG 67
           L+S  A  IG A+  +  ++  +     N+ +         +  +    LW+I V  + G
Sbjct: 25  LVSFLAAIIGTAAGFVAWLLYHLIGFFTNVAFYHTISFTFHSPRNHQLGLWVILVPVVGG 84

Query: 68  IAVGLVIRFS----QGHA-GPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHP 122
           + VG++ ++     +GH          +  + + P       ++  + +  G   G E P
Sbjct: 85  LIVGVMAKYGSSKIRGHGIPEAMEAVLVNRSRIEPKVAILKPLSAAIAIGTGGPFGAEGP 144

Query: 123 IMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVP 181
           I+    A+   IG  +      R       +A  + A F TP+ AA+I +  L       
Sbjct: 145 IIQTGGAIGSLIGQVIQTTASERKVLLGCGAAAGMAATFSTPI-AAVILAIELILFEFKA 203

Query: 182 LWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAV 241
                       A       +   P F +    +G   +       ++ AI   + +   
Sbjct: 204 RSFIPLVIASTIATSLHFVLMGRGPMFEVGAIDFGIPRVLPWY--LLLGAICGFSAVGFS 261

Query: 242 WCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDY 301
             L  +     ++    +     G ++  +     P  L  G D +  ++ N        
Sbjct: 262 KLLYWVEDQFEKLPIDWMWWPAIGCVVLGVVGYFVPRVLGVGYDTISDIL-NTHLVFKVL 320

Query: 302 FLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVL 361
             + + K   L+V   SG  GG + P      A+G  +   +        +S A   +V 
Sbjct: 321 LAVMIFKALVLLVTIGSGTSGGLLAPMFMASAAMGSAVAMIINHFIPGAGISPAAFALVA 380


>UniRef50_UPI0001C418FE voltage-gated chloride channel protein n=1 Tax=Methanobrevibacter
           ruminantium M1 RepID=UPI0001C418FE
          Length = 523

 Score = 97.1 bits (240), Expect = 1e-18,   Method: Composition-based stats.
 Identities = 69/409 (16%), Positives = 153/409 (37%), Gaps = 30/409 (7%)

Query: 7   RTMLLLSLPAVAIGIASSLILIVV---MKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVL 63
           +  L L + AV IG+ S  I+ +    +  +  + + + + + G L +     LW + +L
Sbjct: 16  KYYLKLIIEAVLIGLFSGFIVSLYRLGLDHSESILSYILKYIQGDLTLIV---LWFV-IL 71

Query: 64  TLTGIAVGLVIRFSQGHAGP-DPACEPLIGAPVPP---SALPGLIVALILGLAGGVSLGP 119
            + G+   L++++     G   P     +           L    +   L   GG+SLG 
Sbjct: 72  AIMGLITALLMKWDPDSLGSGIPQVMGEVKGYFDVTWWKTLIAKFIGGTLTALGGLSLGR 131

Query: 120 EHPIMTVNIALAVAIGARLL-PRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSS 178
           E P + +    A  +   L   + +     +  S   + A F  P+A  +   + +N   
Sbjct: 132 EGPSVQLGAMAAKGVSKYLPNSKTDEKRLLVCGSGAGLAATFSAPLAGFIFTLEEINKGF 191

Query: 179 EVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGM 238
           +      +   L++A    L + +FF      PI  +  + +  +    ++  + IA G+
Sbjct: 192 D---RSIVLVGLVSAVVAVLVSNVFFGQS---PIFPFTSLNL-PLEYFWLLIVLGIAIGI 244

Query: 239 VA----VWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQ 294
           +     V  +            P+ +  I  F++  +  +  P  L  G   M  ++   
Sbjct: 245 LGYIYNVGMIKAAEMWDKLSFLPLEIKFIIVFLVTGIVGLFLPEVLGGGYSMMH-LIELS 303

Query: 295 AFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVP---AVPAAIT 351
               S   +L + K   L+    S   GG  +P + +G  +G +    V     +   I 
Sbjct: 304 LPPLSVLIVLLIGKYLLLIFCFGSSAPGGIFYPVLVIGAYIGAIFSAIVIPIFGLNPLIA 363

Query: 352 ---VSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLL 397
              +  ++  +     R    ++ + A +   T  +  + +V++ A+++
Sbjct: 364 YKFIMISMAAMFASSVRTPITAVVLIAEMTGVTNSIVAMIVVVILAYII 412


>UniRef50_C7PH71 Chloride channel core n=2 Tax=Bacteroidetes RepID=C7PH71_CHIPD
          Length = 614

 Score = 96.8 bits (239), Expect = 1e-18,   Method: Composition-based stats.
 Identities = 63/409 (15%), Positives = 135/409 (33%), Gaps = 26/409 (6%)

Query: 12  LSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVG 71
           L L  + +G+ + +  +++  +   +   +  R+  +  +   +    +G+L  T + V 
Sbjct: 48  LILSGILVGLVAGMAGVILKVLVHYIHYFITYRVHFSTQVIFYALFPFLGILLTTILVVW 107

Query: 72  LVIRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALA 131
           +    S+   G          + +P   +   I+   + +  G S G E PI     A+ 
Sbjct: 108 VFKGQSRKGIGLILYEIAQNSSKIPSVKMYSQILQSAITVGLGGSAGLESPIAVTGAAIG 167

Query: 132 VAIGARLLPRVNRMEWTILASAGTIGAL-FGTPVAAALIFSQTLNGSSEVPLWDRLFAPL 190
                            + A A    A  F  P+A  +   + L       ++      +
Sbjct: 168 SNYATNYNLGYKERTLLLAAGATAGIAASFNAPIAGVMFAFEILLTGV---VFSDFIPLI 224

Query: 191 MAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAM 250
           +AA  G+L + +                   ++     +  ++       +     +   
Sbjct: 225 LAAICGSLLSKIILQEEVLFHFETRQPFNYHNVPFYIALGLLSALYARYYIVISQHVEHF 284

Query: 251 MHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVAN-----------QAFSTS 299
           M ++K P L   I G ++  +  +  P    +G   ++ +              +     
Sbjct: 285 MVKLKWPALRKAILGGVIVSILCVLMPPLFGEGYSSLKLLTGGFSDQIIQNSFFRYLPEK 344

Query: 300 DYFLLA------VIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPA-----VPA 348
            + LLA      ++K+ A       G  GG   P++F G  LG              VP 
Sbjct: 345 SWILLAFTGFTCLLKVFATSFTIQGGGNGGNFAPSLFAGGFLGYFFALLCTNFGFQDVPF 404

Query: 349 AITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLL 397
           A  V   + G++  V      ++F+ A       L   L IV   ++++
Sbjct: 405 ANLVLVGMAGVMSGVMYAPLTAIFLIAESSFGYDLFIPLMIVSTISFVV 453


>UniRef50_A3CXC7 Chloride channel protein EriC-like protein n=1 Tax=Methanoculleus
           marisnigri JR1 RepID=A3CXC7_METMJ
          Length = 429

 Score = 96.8 bits (239), Expect = 1e-18,   Method: Composition-based stats.
 Identities = 84/404 (20%), Positives = 156/404 (38%), Gaps = 17/404 (4%)

Query: 17  VAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRF 76
             I + + L  +  + +  +L N++W          Q +P  +   +    + VGL  R+
Sbjct: 32  ALIAVIAILFTVAYLALYGLLNNVVW----SQNNFVQANPWAVPAGVLAFSLLVGLCRRY 87

Query: 77  SQG---HAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVA 133
                   G         G        PG +++ +  L  G S+GPE  I  +   ++  
Sbjct: 88  LHAPDVIHGGFAESLRGGGEKPNYRTFPGALLSSLFSLLSGASIGPEGTITVLIGYVSSY 147

Query: 134 IGARLLPRVNRMEW--TILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLM 191
           +  RL            + A A     + G  +   +  ++   G +    +  L   L+
Sbjct: 148 VRDRLRIGSPGAALGFDVAALASAFNGIVGNVLFTGVFATEFQIGGNR-NAFRFLTWNLL 206

Query: 192 AAAAGALTTGLFFHPHF--SLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHA 249
           A   G L   L   P F  S+P    G++    IL    +  +     + A   +     
Sbjct: 207 AGTVGYLFYLLLGLPSFARSIPFEPIGELHPGYILCAIALGILGSLLAVFAGGAMQAAGT 266

Query: 250 MMHQM--KNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFL-LAV 306
           +M ++    PV  +   G ++  +G    P  LF G  ++  ++A+ A       L +AV
Sbjct: 267 VMDRIFGDAPVARVLAAGAVIACVG-YFIPEVLFSGEAQIHGIIADPARLGVGMLLGVAV 325

Query: 307 IKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLVVTRD 366
           +K+  L ++  SG+ GG +FP +F    +GL L+   P +P  I V C  +  + +    
Sbjct: 326 LKILLLALSFKSGYIGGPLFPIIFSSTLIGLALNLAFPGIPLGIFVLCIEVAALTLALGA 385

Query: 367 GWLSLFMAAVV-VPNTTLLPLLCIVMLPAWLLLAGKPMMMVNRP 409
              S+ + AVV   +   + LL I  + A ++ A     M  +P
Sbjct: 386 PLTSILLVAVVGTADQYTVVLLVISAVTAMVIAAAVKERMGGQP 429


>UniRef50_A1AU45 Cl-channel, voltage-gated family protein n=5 Tax=Desulfuromonadales
           RepID=A1AU45_PELPD
          Length = 481

 Score = 96.4 bits (238), Expect = 2e-18,   Method: Composition-based stats.
 Identities = 67/374 (17%), Positives = 137/374 (36%), Gaps = 14/374 (3%)

Query: 40  LLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRFSQGHA--GPDPACEPLI--GAPV 95
            LW     T   A     +++  +TL  +    V RFS      G D   E +      +
Sbjct: 36  FLWALAQATRLFALIPDYYLLLPVTLV-VCSLFVTRFSPASVCRGTDAIIEAVHQNMGRM 94

Query: 96  PPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAG 154
           P  +LP  ++A ++ +AGG S G E P   +   LA A G  + L  V++ +  I   + 
Sbjct: 95  PLLSLPIKLIATVVTIAGGGSAGKECPSAQIGAGLASAFGRLMRLDDVDQRKLVICGISA 154

Query: 155 TIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAH 214
               +FGTP+A AL   + L       ++D LF   +A   G          +  L  + 
Sbjct: 155 GFATVFGTPIAGALFGVEVL--VLGQMMYDVLFPSFVAGIIGFHVASQLGVEYPHLVASA 212

Query: 215 YGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMM-HQMKNPVLVLGIGGFILGILGV 273
             ++         ++        ++ +  +     +      N +    +GG +L ++G 
Sbjct: 213 IPRLTGWSFAEMLLLGVWCGLIALLFIEMMKLSKRLFNPCAGNAIPKALLGGTLLALIGK 272

Query: 274 IGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGV 333
                 L  G+D ++  +         +     +K  A  +   SG  GG + P +F+G 
Sbjct: 273 FLSTSYLGLGIDTIEAGLKGTVLPVEAWL----VKSVATAITLGSGGSGGVVTPIMFIGA 328

Query: 334 ALGLMLHEHVPAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLP 393
           + G +          A      +  ++        ++  + A+ +    + P   +  + 
Sbjct: 329 SAGNLFASLFNEPQIATFSIIGMAAVLAGAANTP-IAASVMAMELFGAGIAPNAAVACMV 387

Query: 394 AWLLLAGKPMMMVN 407
           ++L++  + +    
Sbjct: 388 SFLIVGYRSIYSSQ 401


>UniRef50_B1Z0X2 Chloride channel core n=79 Tax=Bacteria RepID=B1Z0X2_BURA4
          Length = 468

 Score = 96.4 bits (238), Expect = 2e-18,   Method: Composition-based stats.
 Identities = 73/362 (20%), Positives = 129/362 (35%), Gaps = 24/362 (6%)

Query: 58  WIIGVLTLTGIAVGLVI-RFSQGHAGPDPACEPLIGAP---VPPSALPGLIVALILGLAG 113
           W++  L   G A G V  RF Q  A  +      I  P   VP    P ++VA ++    
Sbjct: 108 WLLWGLPAAGFATGWVYHRFGQSVARGNNLLIDEIHDPKALVPKRMAPLVLVATVVTHLF 167

Query: 114 GVSLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQ 172
           G S G E   + +  ALA  +     L R +R    +   A    ++FGTP+A A+   +
Sbjct: 168 GGSAGREGTAVQMGGALADRVTHLFRLDREHRRVLLMGGIAAGFSSVFGTPLAGAVFGLE 227

Query: 173 TLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHP----HFSLPIAHYGQMEMTDILSGAI 228
            L       +    +  L+   A A+   +        H    I     +  T + +  +
Sbjct: 228 VLA------IGRVRYDALLTCVASAIVADVVCRAWGVHHTVYAIPFVPAVSATGLAATVV 281

Query: 229 VAAIAIAAGMVAVWCLPRLHAMMHQM-KNPVLVLGIGGFILGILGVIGG-PVSLFKGLDE 286
                   G +  +    L     ++ ++  L   +GG I+ +   +   P  L  G+  
Sbjct: 282 AGVAFGVVGRLFAFATHALTGWFRRVVRHAPLQPVLGGAIVAVAATVLNVPQYLGLGIPT 341

Query: 287 MQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAV 346
           ++        +          K A  VV  ASGF+GG + P  ++G  LG  L + + A+
Sbjct: 342 IEAAFHGPLPAYDFA-----GKFAFTVVTLASGFKGGEVTPLFYIGATLGNALGQVL-AL 395

Query: 347 PAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMV 406
           P  +      + +          S  MA  +     +     +  + A+L      +   
Sbjct: 396 PVPVLAGLGFVAVFAGAANTPIASTIMAIELF-GADVGVYAIVACVVAYLFSGHAGIYRA 454

Query: 407 NR 408
            R
Sbjct: 455 QR 456


>UniRef50_B2J2P8 Cl-channel, voltage-gated family protein n=3 Tax=Cyanobacteria
           RepID=B2J2P8_NOSP7
          Length = 863

 Score = 96.0 bits (237), Expect = 2e-18,   Method: Composition-based stats.
 Identities = 79/411 (19%), Positives = 161/411 (39%), Gaps = 26/411 (6%)

Query: 1   MLHPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWII 60
           +L PR    +     A  IG+ S L    V+   +V     W+     L     + L + 
Sbjct: 16  LLRPRRLAFVE----ACIIGLVSGLAA--VLLGQAVDWAGAWRV---HLSYIWPAYLVLP 66

Query: 61  GVLTLTGIAVG-LVIRFSQGHAG----PDPACEPLIGAPVPPSALPGLIVALILGLAGGV 115
           G+  + GI  G LV RF+   +G       A    +  P+        +V+  L L  G+
Sbjct: 67  GIGLVGGILAGWLVERFAPEASGSGMSEVKAVLARVPMPLNLRIALVKLVSATLVLGSGM 126

Query: 116 SLGPEHPIMTVNIALAVAIGARLLPR-VNRMEWTILASAGTIGALFGTPVAAALIFSQT- 173
            LG E P + +  ALA  +   +     +R +     +   + A F  P+A  L   +  
Sbjct: 127 PLGREGPTVQIGAALANQLSNWVPTSPEHRRQLIAAGAGAGLAAAFNAPIAGVLFVVEEL 186

Query: 174 LNGSSEVPLWDRLFAPLMAAAAGALT-TGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAI 232
           L   S + L   + A  +A+    L  +      H  L  +H       +I    I+  +
Sbjct: 187 LQDVSGITLGTAILASFIASVISRLYGSHSLDLNHLDLSFSH-TTFFAQEIPFYLILGVL 245

Query: 233 AIAAGMVAVWCLPRLHAMMHQMKNPVLV--LGIGGFILGILGVIGGPVSLFKGLDEMQQM 290
               G++    +    A+  ++ N  L   +GI G + G+  +   P++ F+    ++++
Sbjct: 246 GGLIGILFNKSILASLAINRRLLNLSLPWRIGIVGLVTGV-AIALLPIT-FRNNAGLREI 303

Query: 291 VANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLH----EHVPAV 346
           +   + +     +  +++   +++   SG  GG + P + +G ALG ++       +   
Sbjct: 304 LLVGSGNWLFAAIALLVQFTLIILTYGSGAPGGLLVPTLVLGAALGYLVGAAEQSLLGMS 363

Query: 347 PAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLL 397
            A       +  +   V++    ++ +   +  +  L+  L IV + A+L+
Sbjct: 364 AATTYAHVGMAALFSAVSKVPITAVVIVFEMTTDFNLVLPLMIVSVIAYLV 414


>UniRef50_Q2BHE2 Cl-channel, voltage gated n=1 Tax=Neptuniibacter caesariensis
           RepID=Q2BHE2_9GAMM
          Length = 574

 Score = 96.0 bits (237), Expect = 2e-18,   Method: Composition-based stats.
 Identities = 59/324 (18%), Positives = 104/324 (32%), Gaps = 15/324 (4%)

Query: 17  VAIGIASSLILIVVMKIASVLQNL-LWQRLPG--TLGIAQDSPLWIIGVLTLTGIAVGLV 73
           V +GI   L+  VV+    +L  + L   LPG  +    + S  +   +  +  + +  +
Sbjct: 25  VVLGIICGLLCGVVLGSFRLLLEVPLAHLLPGGESENFEELSGWYHFFLPVIGSLIIIAI 84

Query: 74  IRFS-----QGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNI 128
           +        +              + +P        +     L  G S+G E P + +  
Sbjct: 85  LSRVTPLTRKVGVTHLLERMAYHQSNLPLKNAIVQFLTASTALLFGHSVGKEGPAIHLGA 144

Query: 129 ALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLF 187
                +G +L LP           +A  I A F TP+A  +   + +     V       
Sbjct: 145 TCGSQLGQKLNLPNNTLRILAGCGTAAGIAATFNTPLAGVVFAMEVVLLEYTV---IGFM 201

Query: 188 APLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRL 247
             ++AAA GAL     F     L +       +++I   A +  +     +  +  +   
Sbjct: 202 PVMVAAATGALVMQFMFGQELVLTVPAMQIESLSEIPYVAFLGGMIGLLAVAFISLMRET 261

Query: 248 HAMM-HQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAV 306
                H +      L I G   G + V   P  +  G D +   V N          + +
Sbjct: 262 MRWSDHSVLTYKTKLIIAGLFTGSVAVFV-PQVMGVGYDTVTS-VLNGELGLGILIAILI 319

Query: 307 IKLAALVVAAASGFRGGRIFPAVF 330
            K     V    G   G I P  F
Sbjct: 320 AKCLLTPVVLGLGIPAGLIGPTFF 343


>UniRef50_D0KW58 Cl-channel voltage-gated family protein n=1 Tax=Halothiobacillus
           neapolitanus c2 RepID=D0KW58_HALNC
          Length = 604

 Score = 96.0 bits (237), Expect = 2e-18,   Method: Composition-based stats.
 Identities = 75/396 (18%), Positives = 143/396 (36%), Gaps = 20/396 (5%)

Query: 12  LSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVG 71
           +++  +  GI +S ++ +       LQ      LP     +     W   + TL GI +G
Sbjct: 25  MAILGLFAGIVASALVTLFRFTLESLQIYFLG-LPSPDNYSALPIEWRFWLPTLGGIILG 83

Query: 72  LVIRFSQGHA-----GPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTV 126
           +        A     G          A +P         + + GL  G+S G E P + +
Sbjct: 84  VAFMLIPQAARAVGVGFVIIRFHRSQADLPWPNAIVQFFSAVWGLLVGLSNGREGPGVHL 143

Query: 127 NIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDR 185
                  +G RL LP+ +        +A  I A F TP+AA ++  + +     +     
Sbjct: 144 GATAGSLLGQRLDLPQNSVRTLVGCGAAAAIAASFNTPLAAVILVLELIVRQYTLA---T 200

Query: 186 LFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLP 245
               ++A++AGAL + LFF  + +  I  Y  + + +I    ++  +  A          
Sbjct: 201 FIPIILASSAGALFSTLFFGDNPAFNIQLYHSLALWEIPVLVLLGLVIGAFSAAYTHIAE 260

Query: 246 RLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLA 305
                  +     L  G+ G I G++G+   P  +    D +  + A   F+      L 
Sbjct: 261 VSIHRTWKWPV-WLRFGLIGIITGLVGM-YLPQIMSISYDSV-GLAAGAKFTLLLLLFLI 317

Query: 306 VIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEH------VPAVPAAITVSCAILGI 359
           V KL    +    G   G I P + +G   G            +P    A      +  +
Sbjct: 318 VAKLLLSALTLGFGLPLGSIGPTLVIGGFTGSAFGTVLLSFTQIPISDVAYYTVLGMGAM 377

Query: 360 VLVVTRDGWLSLFMAAVVVPNT-TLLPLLCIVMLPA 394
           +    +    +L     +  +T T++P +  +++ +
Sbjct: 378 MGATLQAPLAALTAVIELTGDTGTIMPAMVTIIIAS 413


>UniRef50_Q3AQR7 Chloride channel, putative n=12 Tax=Chlorobiaceae
           RepID=Q3AQR7_CHLCH
          Length = 631

 Score = 96.0 bits (237), Expect = 3e-18,   Method: Composition-based stats.
 Identities = 59/398 (14%), Positives = 134/398 (33%), Gaps = 23/398 (5%)

Query: 16  AVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWI---IGVLTLTGIAVGL 72
           AV +G+ +  + ++  +    + N  +  L     I+     W+     +  + G+ VGL
Sbjct: 60  AVIVGLVTGYVAVLFHEAIKAISNFSFNDLRLLGDISFIEQYWVFFLPFIPAIGGLFVGL 119

Query: 73  -----VIRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVN 127
                + + S+                +         +  ++ +  G   G E PI+ V 
Sbjct: 120 YNTFIIKKSSRHALASVIKSVAHNDGIIDRKLWFHKTITSVVCIGTGGGGGREAPIVQVG 179

Query: 128 IALAVAIGARLLPR-VNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRL 186
            A+   I   L              +A  + A+F  P+ A +   + L G   V      
Sbjct: 180 SAIGSTIAQWLRFSPEKTRTLLGCGAAAGLAAVFNAPIGAVMFAIEVLLGDFSV---KTF 236

Query: 187 FAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPR 246
              ++AA  G + +  F     +  +  Y  +   ++L   ++  +A  + ++ +     
Sbjct: 237 SPIVIAAVIGTVLSRSFLGNRPTFDVPDYTLVSNIELLFYCVLGVLAGLSAVMFIKTYFA 296

Query: 247 LHAMMHQMKN----PVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYF 302
           +     +++     PV ++   G  L  +  I  P       + +   V        +  
Sbjct: 297 IEEWFDKLQIRRNLPVWIMPAIGGFLSGIICIWLPGLYGFSYNVISNAVYGNETWY-NLI 355

Query: 303 LLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLML----HEHVPAVPAAITVSCA--I 356
            + ++K     ++  SG  GG   PA+ +G  LG M     H+  P + A         +
Sbjct: 356 GIYLLKPVVAGLSIGSGGAGGMFAPAMKMGAMLGGMFGIVVHQFFPLITATSGAYALVGM 415

Query: 357 LGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPA 394
             +   V R     + +   +     ++  +    + +
Sbjct: 416 GALTAGVMRAPLTVILILFEITGQYEIVLPIMFAAVTS 453


>UniRef50_A3ZLX7 Chloride channel protein n=1 Tax=Blastopirellula marina DSM 3645
           RepID=A3ZLX7_9PLAN
          Length = 449

 Score = 95.6 bits (236), Expect = 3e-18,   Method: Composition-based stats.
 Identities = 78/381 (20%), Positives = 136/381 (35%), Gaps = 36/381 (9%)

Query: 16  AVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIR 75
            + +GI     + + +    V+  L W               W++ +L L GIA GL+  
Sbjct: 24  CLPLGIVVGSSVAIFLWALHVVTLLQWDN------------SWLLYLLPLAGIASGLMYH 71

Query: 76  FS--QGHAGPDPACEPLI--GAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALA 131
           +   +  AG +   E +   G  VP    P +++  ++    G S G E   + +  +LA
Sbjct: 72  YLGREAEAGNNLIMEQIHQPGGGVPLRMAPLVLIGTLITHLFGGSAGREGTAVQMGGSLA 131

Query: 132 VAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPL 190
             +G  L L             A   GA+FGTP+  A+   + +  +     +  L   L
Sbjct: 132 GVLGRLLKLTPDETRILLSAGVAAGFGAVFGTPLTGAIFAVEVI--AIGKMSYKALIPCL 189

Query: 191 MAAAAGALTTGLF----FHPHFSLPIAHYGQMEMTDILSGAI--VAAIAIAAGMVAVWCL 244
           +A+  G      +     H H          +    +       VA  AI  G+ +V   
Sbjct: 190 LASVIGDQVNTAWGIGHTHYHIGFAAEISSSLSAVSLDWALTGKVAIAAIFFGLASVLFA 249

Query: 245 PRLHAMMHQMKN----PVLVLGIGG-FILGILGVIGGPVSLFKGL-----DEMQQMVANQ 294
              HA+    K     P L   +GG  ++ ++ ++G    L  G+     D     + + 
Sbjct: 250 ELTHAISGTAKRFIAIPWLRPAVGGCVVIALVWLLGTRDYLGLGVTPHPPDSGMICIESC 309

Query: 295 AFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSC 354
                  ++    KL    V   SGF+GG + P  F+G ALG +    +   P  +    
Sbjct: 310 FQPGGADWMSWWWKLLFTAVTVGSGFKGGEVTPLFFIGAALGNVTGVML-GAPVDLMAGL 368

Query: 355 AILGIVLVVTRDGWLSLFMAA 375
             + +    T        MA 
Sbjct: 369 GFVAVFAGATNTPLACTIMAI 389


>UniRef50_B3Q6A2 Chloride channel core n=4 Tax=Rhodopseudomonas palustris
           RepID=B3Q6A2_RHOPT
          Length = 604

 Score = 95.6 bits (236), Expect = 3e-18,   Method: Composition-based stats.
 Identities = 69/381 (18%), Positives = 132/381 (34%), Gaps = 15/381 (3%)

Query: 12  LSLPAVAIGIASSLILIVVMKIASVLQNLLWQ-RLPGTLGIAQDSPLWIIGVLTLTGIAV 70
           L + AV IG+ S L++ ++ +++     +L+       L            ++ L G  +
Sbjct: 43  LVMVAVVIGLLSGLLVAIIWRLSEFAHAVLFNIPFDTRLSANGVISWQRTLLVPLGGAVI 102

Query: 71  GLVIR-----FSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMT 125
             +I        +G          L G  V       + +  +L    G S+G E     
Sbjct: 103 LTIIGVFYAGRFKGRLADAIEANALYGGRVSMRGSLLISLQTLLSNGCGASVGLEAGYTQ 162

Query: 126 VNIALAVAIGARLLPR-VNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWD 184
           +  A    IG RL  R  +        +AG I A F  P+A A    + + G+       
Sbjct: 163 ICAAFGSQIGQRLAARRADMRLLVACGAAGAISAAFTAPLAGAFFAFEVVLGAYT---SA 219

Query: 185 RLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCL 244
            L   + +A +  L      HP F           +  I    ++  +     ++ +  +
Sbjct: 220 SLVPVIASAVSSWLVMRNLVHPSFLQIPGVPTPASVEMIGQTMLLGVLCAFFSILVMLAV 279

Query: 245 PRLHAMMHQMKN-PVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFL 303
                +   +      +  + G +L     +  P  L  G   MQ ++            
Sbjct: 280 AFSERVFQSISIWRGALRLVIGALLLSGLALLSPTVLGSGHGAMQLLLITNPTWLMLLTT 339

Query: 304 LAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITV---SCAILGIV 360
           L +  LA+  V+  +GFRGG  F ++ +G  +G +    +      I +   + A+ G+V
Sbjct: 340 LILKTLAS-AVSLGAGFRGGLFFASLMLGSLIGQLYSTVLTPYFPDIALQPGTAAVAGMV 398

Query: 361 LVVTRDGWLSLFMAAVVVPNT 381
            + T        M  + +  T
Sbjct: 399 ALGTGVIGAPFSMICLALELT 419


>UniRef50_C2GZL1 Voltage-gated chloride channel family protein n=19 Tax=Enterococcus
           faecalis RepID=C2GZL1_ENTFA
          Length = 405

 Score = 95.6 bits (236), Expect = 3e-18,   Method: Composition-based stats.
 Identities = 78/402 (19%), Positives = 141/402 (35%), Gaps = 18/402 (4%)

Query: 5   RARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLT 64
           R R M  + +  + +    + I    + I   L  LLW+ LP  +   +   L+   +  
Sbjct: 2   RNRKMWTIIVSGLFLSSIIAGISGAFLIIEGELTTLLWEVLPAQM---KWPILYYFVLCV 58

Query: 65  LTGIAVGLVIRFSQGHAGPDPAC------EPLIGAPVPPSALPGLIVALILGLAGGVSLG 118
           L      LV+ + +   G  P        E      V  S +   ++A ++ L  G  +G
Sbjct: 59  LG----ALVLSYLKKRFGQVPQTAHEALKELKAKQSVDYSGVFRNLLAALVILIFGAGVG 114

Query: 119 PEHPIMTVNIALAVAIGARLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSS 178
           PE  ++   I+L+V    +L       +     +          P      +   L  + 
Sbjct: 115 PEAALLGAIISLSVWQSDKLRYLYFHYDEQEQQAFWIKIQRLLHPQQFVQRYDTMLASAD 174

Query: 179 EVPLWDRLFAPLM--AAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAA 236
           +  L   +    +            L  HP F   +   G++EM  +         A   
Sbjct: 175 KKKLKQMMNGLFIVNGLVVFTFLMKLVGHPSFITKLGT-GKIEMASLWLILPALLTAFVI 233

Query: 237 GMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAF 296
           G    W    L  +    +    +L   G     L VI  P  LF G   M  + +  + 
Sbjct: 234 GKAYRWLKAALAKLCQPFEEKQSILVSFGAACIFLFVILMPRLLFSGQSFMHLVPSFGSQ 293

Query: 297 STSDYFLLA-VIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCA 355
                 ++A ++KL  L V   +G+ GG IFP VF  + +G  + +  P + +   V+  
Sbjct: 294 QAWYILVVAAIMKLVFLQVCLQTGWIGGDIFPVVFSAILIGFAVAQFFPTIDSLFVVAIF 353

Query: 356 ILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLL 397
              +   +     L   +   +    TL P++ +V+   WLL
Sbjct: 354 ATSLTTQILGT-ILVPGIFVGLFFQITLWPVVVLVLFLQWLL 394


>UniRef50_C1SIP9 Chloride channel protein EriC n=1 Tax=Denitrovibrio acetiphilus DSM
           12809 RepID=C1SIP9_9BACT
          Length = 595

 Score = 95.6 bits (236), Expect = 3e-18,   Method: Composition-based stats.
 Identities = 72/371 (19%), Positives = 134/371 (36%), Gaps = 15/371 (4%)

Query: 57  LWIIGVLTLTGIAVG-LVIRFSQGHAGP--DPACEPLIGAPVPPS-ALPGL-IVALILGL 111
             I+ V  L G+  G LV +F+    G   D A + +          +P +   A  + +
Sbjct: 73  WSILLVPALGGLISGFLVYKFAPEAEGHGTDAAIKAIHFKNGSIRWRVPIIKTFASAITI 132

Query: 112 AGGVSLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIF 170
             G S G E PI  +       +G  L L    R   T       +GA+F +P+A A+  
Sbjct: 133 GTGGSGGREGPIAQIGAGFGSFLGTTLKLSERERRILTAAGMGAGVGAIFRSPLAGAIFA 192

Query: 171 SQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVA 230
           ++ L  SS++  ++ L    + +          +          +      +++  +++ 
Sbjct: 193 AEVLYASSDME-YEALLPSAITSIIAYSVFCSVYGWEPLFATPDFAFENPVELIGYSVLG 251

Query: 231 AIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQM 290
                 G + V     +H +  QM     +  + G  L        P +L     +++  
Sbjct: 252 FACAVFGWLYVRTFYGIHGIFKQMHISPYIKPVIGGFLTGCVGFFVPQALAGSYAQIELG 311

Query: 291 VANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVA----LGLMLHEHVPAV 346
           +  Q       F+L   K+     +  SG   G   P++ +G A    +GL L+  VP +
Sbjct: 312 MQGQ-LGIGFIFILIFAKILTTSFSIGSGGSAGIFGPSMVIGAAVGGFVGLALNSFVPFI 370

Query: 347 PAAIT--VSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMM 404
                  V   + G    +      ++ M + +  N  LL     V   A+LLL    M 
Sbjct: 371 APEPGAYVIVGMAGFFSGIANTPLSTIIMVSEMTGNYHLLVPSMWVSTLAFLLLRKTTMY 430

Query: 405 MVNRP-KQQPP 414
           +   P + + P
Sbjct: 431 VNQVPMRSESP 441


>UniRef50_B8DM62 Chloride channel core n=3 Tax=Desulfovibrionales RepID=B8DM62_DESVM
          Length = 605

 Score = 95.2 bits (235), Expect = 4e-18,   Method: Composition-based stats.
 Identities = 61/288 (21%), Positives = 106/288 (36%), Gaps = 17/288 (5%)

Query: 56  PLWIIGVLTLTGIAVG-LVIRFSQGHA-----GPDPACEPLIGAPVPPSALPGLI--VAL 107
           P  I+  L +TG+  G LV RF          G D                  L+  +  
Sbjct: 83  PWVIVAALGITGLVTGWLVQRFLPNSLDGMTDGTDAMIRAFHAEKGVIRRRAPLLKGLTS 142

Query: 108 ILGLAGGVSLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAA 166
           I  +A G S G E P+  +   +   +  RL L    R    +  +AG +GA+F  P+  
Sbjct: 143 ICTIAAGGSAGREGPVSQIGAGIGSWLSMRLGLSPRERRILMLAGAAGGLGAVFRAPLGG 202

Query: 167 ALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSG 226
           AL   + L         + L   ++++          F       I  +    + ++   
Sbjct: 203 ALTAIEVLYREDFE--SEALLPAVLSSVVSYSLFTFVFGTAPIFGIPRFSFTSVLELPWY 260

Query: 227 AIVAAIAIAAGMVAVWCLPRLH-AMMHQMKNPV---LVLGIGGFILGILGVIGGPVSLFK 282
            +++    A G   V     L  ++  +++  V       +GG ++G+ G++  PV L  
Sbjct: 261 LLLSLACAATGWAYVRTFRVLKYSVFGKLRARVGIMWTTALGGVLMGLFGILYPPV-LSD 319

Query: 283 GLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVF 330
           G   ++Q +  Q         + + K  A  V   SG  GG   PA+F
Sbjct: 320 GYGWIEQAILGQ-LPVVTMVTILLGKTLATAVTLGSGMSGGMFAPALF 366


>UniRef50_A6TWM3 Chloride channel, core n=1 Tax=Alkaliphilus metalliredigens QYMF
           RepID=A6TWM3_ALKMQ
          Length = 426

 Score = 95.2 bits (235), Expect = 4e-18,   Method: Composition-based stats.
 Identities = 66/342 (19%), Positives = 133/342 (38%), Gaps = 16/342 (4%)

Query: 51  IAQDSPLWIIGVLTLTGIAVGLVIRFSQGHAG----PDPACEPLIGAPVPPSALPGLIVA 106
           ++   P+W+  V  + GI V LV  +    +G                +   +    ++A
Sbjct: 43  LSTYVPIWLAPV--IGGILVVLVYLWDTTASGFGTDRYMCAVNEEKGYLKFRSSISKLIA 100

Query: 107 LILGLAGGVSLGPEHPIMTVNIALAVAIGA-----RLLPRVNRMEWTILASAGTIGALFG 161
             L +    S G E P++ +  +    +       R L + +    TI  +AG IGA+F 
Sbjct: 101 SALTIGFQGSGGVEGPMLIIGGSAGSTLSRIPILNRFLDKDDYRILTICGAAGAIGAIFR 160

Query: 162 TPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMT 221
           +P+   +   + L  SS    +  LF  ++++  G +   +  + +    I  Y    + 
Sbjct: 161 SPLGGGIFVVELLYRSSL--HYFELFPAILSSTMGFVVFSMLANGNPIFMIPDYLP-NVF 217

Query: 222 DILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLF 281
           ++ +  +   +     ++ +    +  A   QM         GG + G++ +I  P    
Sbjct: 218 NVPTFILAGVLGGIMSLIFMAVFSKTKATFDQMSFKRFHPIAGGLLTGVI-LIYLPRVGG 276

Query: 282 KGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHE 341
            G   +Q+M+ +   S     LL V K+ A      SG   G + PA+F+G   G + + 
Sbjct: 277 AGTSMIQEMI-DSPQSYHLLLLLFVGKMLATSFTVGSGGSAGLVIPALFIGAIAGSISNN 335

Query: 342 HVPAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTL 383
            +  V   ++ S  I G+   +     + +  A ++V    L
Sbjct: 336 LLSVVDPGLSASLVISGMAASLASIANVPIAAAIMLVEMVGL 377


>UniRef50_C9KMS0 Voltage-gated chloride channel family protein n=1 Tax=Mitsuokella
           multacida DSM 20544 RepID=C9KMS0_9FIRM
          Length = 519

 Score = 95.2 bits (235), Expect = 4e-18,   Method: Composition-based stats.
 Identities = 67/402 (16%), Positives = 136/402 (33%), Gaps = 23/402 (5%)

Query: 10  LLLSLPAVAIGIASSLILIVVMKIASVLQNLL---WQRLPGTLGIAQDSPLWIIGVLTLT 66
           L L +    IG+A+ +++ +   +  + +  L   ++ LP  +      P+W + +   +
Sbjct: 20  LRLFIEGNIIGVATGMVIALFRYLLELSEEYLPVLYRWLPEHI---VWIPIWFLALFLCS 76

Query: 67  GIAVGLVIRFSQGHAGPDPACEPLIGAPVP---PSALPGLIVALILGLAGGVSLGPEHPI 123
            I   +V +         P  + ++   +       L       +LG+  G+SLG E P 
Sbjct: 77  WILYRIVSKDGMTSGSGIPQIKGILLGEMDMNWARVLVLKFTGAVLGIGAGMSLGREGPS 136

Query: 124 MTVNIALAVAIGARLLPR-VNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPL 182
           + +   L   +G                 +   + A F  P+A  +   + L  +     
Sbjct: 137 VQLGACLGQGLGRLTHRSYAESHYLLTAGAGAGLAAAFNAPLAGVIFCLEELTKNFSA-- 194

Query: 183 WDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVW 242
              L   + AA      T  FF       +     ++  D+    I+  +    G++ + 
Sbjct: 195 -FVLMGAISAAVTATTVTQYFFGMQPVFHMGVVPVIDTGDMYFLLIL--LGAFVGLLGLA 251

Query: 243 CLPRLHAMMHQMKN-PVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDY 301
             P L       K  P     +       +     P  L  G   +  +V    ++ +  
Sbjct: 252 FNPMLTRSQDFYKKVPARWRPVVPLFCAGVLGFVLPQVLGGGSRLVDSLVV-TDYTLAFL 310

Query: 302 FLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHE---HVPAVPAAITVSCAILG 358
            LL   K    +V   SG  GG   P + +G   G +  +       +P    V+C + G
Sbjct: 311 VLLLAAKFLFTMVCFGSGVPGGIFLPMLVLGSVGGAVFAKVAIFFQWMPELFAVNCIVFG 370

Query: 359 IVL---VVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLL 397
           +      V +       +   +  +   +  L IV + A+L+
Sbjct: 371 MAAYFSAVVKSPITGSILIMEMTGSFEHMLALIIVSMTAYLV 412


>UniRef50_C1F836 Chloride transporter, ClC family n=1 Tax=Acidobacterium capsulatum
           ATCC 51196 RepID=C1F836_ACIC5
          Length = 584

 Score = 95.2 bits (235), Expect = 4e-18,   Method: Composition-based stats.
 Identities = 80/406 (19%), Positives = 158/406 (38%), Gaps = 27/406 (6%)

Query: 6   ARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTL 65
            R  L+LS+    IG+ S L+++             W ++             ++ +  L
Sbjct: 36  ERLFLVLSIF---IGVISGLLVVAFR------SAYEWIKILALGSAPHPGQYRLMYMPAL 86

Query: 66  TGIAVG-LVIRFSQGHAGP----DPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPE 120
            G+ V  LV+    G  G       A   +    +    + G  +   L +  G SLGPE
Sbjct: 87  VGLVVASLVVWLFPGARGSGVNQTKAALYVYNGYISFKTVIGKFITAALAIGSGQSLGPE 146

Query: 121 HPIMTVNIALAVAIGARLLPRVNRMEW-TILASAGTIGALFGTPVAAALIFSQTLNGSSE 179
            P + +   +A  I  RL     R+     + +A  + A F  P++A L   + + GS  
Sbjct: 147 DPSLQIGAGVASMIARRLRMSRQRLRMFAPIGAAAGLAAAFNAPISAILFVIEEVIGSWS 206

Query: 180 VPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMV 239
             +   L + ++AA +  +   LF+       +      +  ++L+ A++        ++
Sbjct: 207 AAV---LGSVVLAAISSEVVARLFWGSEPMFHVPPVELRDPRELLAYAVLGVTGGFLAVI 263

Query: 240 AVWCLPRLHAMMHQMKNPVLVL--GIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFS 297
               L  L  +M  +      +   I G ++G +G  G P  +  G   + Q   +  F+
Sbjct: 264 FSKALGYLRPVMRNLPRWTHFVQPAIAGLLVGAIGFFGFPQVMGPGYTVIDQ-ALHAEFT 322

Query: 298 TSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLML----HEHVPAVPAAITVS 353
                 LA++K+ A  ++ +SG  GG   P +F+G  LG  +    H   P +   +   
Sbjct: 323 WKILLALALLKMLATALSFSSGTPGGMFAPTLFIGAMLGGAVGTFEHHFFPHLVGTVGAY 382

Query: 354 CA--ILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLL 397
               +  +     R    S+FM   +  N++++  + +    A+L+
Sbjct: 383 ALVGMGVLFAGFLRVPLTSVFMVLELSGNSSIILPVVLANTIAYLI 428


>UniRef50_Q892T8 Chloride channel protein n=1 Tax=Clostridium tetani
           RepID=Q892T8_CLOTE
          Length = 526

 Score = 94.8 bits (234), Expect = 5e-18,   Method: Composition-based stats.
 Identities = 64/401 (15%), Positives = 138/401 (34%), Gaps = 22/401 (5%)

Query: 12  LSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGV---LTLTGI 68
           L L ++ +G+ + +++++   +   + N     L   + I  +S +++      L + GI
Sbjct: 20  LILESILVGLITGIVVVLFRILLDKVTNFRNYAL---IFIKNNSIVYVGMWFLFLIIAGI 76

Query: 69  AVGLVIRFSQGHAGP-DPACEPLIGAPVPP---SALPGLIVALILGLAGGVSLGPEHPIM 124
             G++I       G   P  + +    +       L       +  L  G+SLG E P +
Sbjct: 77  VFGILIEKIPMIKGSGIPQVKGVFLRQLKMDWLRELVAKFFGGVASLGIGLSLGREGPSV 136

Query: 125 TVNIALAVAIGARLLPRVNRMEWTIL-ASAGTIGALFGTPVAAALIFSQTLNGSSEVPLW 183
            +   + +        R    ++ I   ++  + A F  P+A  +   + L+ S    + 
Sbjct: 137 QLGSEVGLGFCRVFKRRPFEEKYLITSGASAGLSAAFNAPLAGVVFSLEELHKSFNSLVL 196

Query: 184 DRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVA-VW 242
                  +AA     T  L   P FS        +     L    +            + 
Sbjct: 197 ACAMGASLAANF-ISTRFLGLKPVFSFENVKALPLNKYHYLILLGIIIGISGRIFNYSIL 255

Query: 243 CLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYF 302
            +  ++  +  +KN      +  FI+  +  +  P  L  G   ++ +  N+ F  S   
Sbjct: 256 KVQDIYKDIKVLKNRY--KTVIPFIVTGVIGLTVPEMLGGGHSLVENLSKNE-FLLSTLL 312

Query: 303 LLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEH------VPAVPAAITVSCAI 356
           +  ++K    +V   SG  GG   P + +G  +G            +P+         A+
Sbjct: 313 IFIIVKFLFTIVCYGSGVPGGIFLPLLALGALIGKTYGVTLVEYANLPSGYIINFTILAM 372

Query: 357 LGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLL 397
                 +TR       +   +  +      L ++   A+L+
Sbjct: 373 AANFTAITRAPITGSILILEMTNSFNSFLELMVITTVAYLI 413


>UniRef50_A3NY48 Chloride transporter, chloride channel (ClC) family n=71
           Tax=Burkholderiales RepID=A3NY48_BURP0
          Length = 578

 Score = 94.8 bits (234), Expect = 5e-18,   Method: Composition-based stats.
 Identities = 71/364 (19%), Positives = 136/364 (37%), Gaps = 25/364 (6%)

Query: 50  GIAQDSPLWIIGVLT-LTGIAVGLVIRFSQGHAGP-DPACEPLIGAPVPP--------SA 99
            + Q  P     +   +  ++V L  RF +G  G   P     + A              
Sbjct: 76  SLGQGRPWLPFLLTPAIAALSVWLTRRFFRGAEGSGIPQVIATLHAQPSAFGSRLLTLRI 135

Query: 100 LPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARLLPRVNR---MEWTILASAGTI 156
           L G ++  +LG+AGG ++G E P + +  +L   +  R  PR N     +  +  +A  +
Sbjct: 136 LFGKVLISLLGIAGGFTIGREGPTVQIGASLMFNL-RRFYPRSNALIERQLVLAGAAAGL 194

Query: 157 GALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGAL------TTGLFFHPHFSL 210
            A F TP+A  +   + L+ S        L   ++ A   AL      T           
Sbjct: 195 SAAFNTPLAGVVFAIEELSRSFSARASGVLITAIIIAGVIALGLNGNYTYFGTIEIGQHF 254

Query: 211 PIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGI 270
           P      + +T +++G               W   RL  +    + P++     G  +  
Sbjct: 255 PKMLAAAVLLTALVTGVAGGLFGWLLLNTGRWLPARL--LALYRERPIVFAAACGLAIAA 312

Query: 271 LGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVF 330
           +GV  G  +   G  E + ++  +   +    L   +K+ ++V +   G  GG   P++ 
Sbjct: 313 VGVASGGTTFGSGYAEARGLLDGREQLSV---LYPFLKMISMVASYLPGIPGGIFAPSLS 369

Query: 331 VGVALGLMLHEHVPAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIV 390
           +G   G +LH     +   + ++ A++G +  VT+    S  +   ++    L+  L   
Sbjct: 370 IGAGFGNLLHFVFSGMHLPMLIALAMVGYLAAVTQSPITSFVIVMEMINGHALVISLMAT 429

Query: 391 MLPA 394
            L A
Sbjct: 430 ALIA 433


>UniRef50_C0W1S0 H(+)/Cl(-) exchange transporter n=1 Tax=Actinomyces coleocanis DSM
           15436 RepID=C0W1S0_9ACTO
          Length = 501

 Score = 94.8 bits (234), Expect = 5e-18,   Method: Composition-based stats.
 Identities = 84/399 (21%), Positives = 155/399 (38%), Gaps = 26/399 (6%)

Query: 6   ARTMLLLSLPAVAIGIASSLILIVV---MKIASVLQNLLWQRLPGTLGIAQDSPLWIIGV 62
           AR++ LL   A  +GI++ LI       ++    L+  L   L G   +     L+I   
Sbjct: 42  ARSLFLLCFAAALVGISTGLIAASFRIGLEWVLELRFGLIDLLDGQAVLGFI--LFIAVT 99

Query: 63  LTLTGIAVGLVIRFSQGHAGP-DPACEPLIGAPVPP---SALPGLIVALILGLAGGVSLG 118
             LTG++  LV + S    G   P  E ++   + P     LP   V  ++ +  G+ LG
Sbjct: 100 TILTGLSALLVAKVSPDAEGSGIPRVEAIVNGHLEPGRSRILPVKFVGGLMAIGSGLMLG 159

Query: 119 PEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGS 177
            E P++ +  + A  +     L   +        +A  +   F  P+A  +   + L   
Sbjct: 160 REGPLVQMGASAAYTVNKYFRLKDDDLRVLMGAGAAAGLATAFNAPIAGGVFVLEELLKR 219

Query: 178 SEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAG 237
            ++       A L+A+ AG +++ L     F   I    Q+  T I    ++  +    G
Sbjct: 220 FDI---RTTLATLVASGAGFVSSILLVDSRFEFIIGWAPQVTNTSIHWVVLIGILCGFLG 276

Query: 238 MVAVWCLPRLHAMMHQMKNPVLVL-GIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAF 296
           ++    +         +K P  +  G+ G +LGI+G      ++  G D + Q       
Sbjct: 277 IIYNDYVMWCLRFADTLKPPAFIRGGVVGLVLGIVG--WFAPAIVGGGDNLTQQALLGNG 334

Query: 297 STSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLH--------EHVPAVPA 348
                  +  ++     ++ A+G  GG   P + +G  LG+++          H P+VPA
Sbjct: 335 GLGLAVAILAVRFILGPISYAAGTPGGLFAPQLVIGSTLGMIIGIIANSVQPNHSPSVPA 394

Query: 349 AITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLL 387
           A  +   +        R     L +A+ +  N T LP +
Sbjct: 395 AALIG--LSAFFSATVRTPITGLILASEMTGNVTALPAM 431


>UniRef50_Q15SM8 Cl-channel, voltage gated n=1 Tax=Pseudoalteromonas atlantica T6c
           RepID=Q15SM8_PSEA6
          Length = 544

 Score = 94.8 bits (234), Expect = 6e-18,   Method: Composition-based stats.
 Identities = 65/339 (19%), Positives = 121/339 (35%), Gaps = 14/339 (4%)

Query: 55  SPLWIIGVLTLTGIAVGLVI-RFSQGHAGP----DPACEPLIGAPVPPSALPGLIVALIL 109
              W+  V TL G+  G+++ R +    G                +         +A  +
Sbjct: 50  PLYWVPVVTTLGGLISGVIVYRLAPEAEGHGTDAYIEAFHQHDGAIRSRVPWVKALASAI 109

Query: 110 GLAGGVSLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAAL 168
            +  G S G E P   +   +A  +  R  L    R   T++A+A  + A+F +P+ +AL
Sbjct: 110 TIGSGGSAGREGPTAQICAGIAAILADRFGLANAERRLLTVVATAAGLSAIFKSPLGSAL 169

Query: 169 IFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAI 228
              + L     +      FA L +A A  +   +          A        ++     
Sbjct: 170 FAVKVLYSGFSMETRALYFAILASATAYTIMGFVVGWSPIFNIQAALSLTHPMELSWYVG 229

Query: 229 VAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQ 288
           +   +     +       +  +   +  P  +    G +L  L  +  P  L  G   ++
Sbjct: 230 LGIASGIVASIIPTIFYTIRDLFRLINIPHFIKPAIGGLLLGLIAMWIPQILGGGYQWIE 289

Query: 289 QMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPA 348
            +  N   S +   +L ++K  A+ +   SG  GG   P +F+G  LG +  E   AV  
Sbjct: 290 -LAINHQLSLTVLLVLLLLKPLAMALTIGSGGSGGIFAPTLFIGAMLGAVFAELAGAVD- 347

Query: 349 AITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLL 387
                 ++          G L+LF AA   P  +L+ ++
Sbjct: 348 ------SLSPSYASCVIIGMLALFGAAARTPLASLVMIM 380


>UniRef50_B5EQW9 Chloride channel core n=2 Tax=Acidithiobacillus ferrooxidans
           RepID=B5EQW9_ACIF5
          Length = 474

 Score = 94.4 bits (233), Expect = 6e-18,   Method: Composition-based stats.
 Identities = 75/426 (17%), Positives = 144/426 (33%), Gaps = 32/426 (7%)

Query: 5   RARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNL---------------LWQRLPGTL 49
           + +      +  V IGI   ++ +V + I      L                   +    
Sbjct: 32  KGKNKARYFITPVIIGIIVGVLSLVFIDIMDFFTRLSLGVVAHFTPPRSSGFGGGVESRY 91

Query: 50  GIAQDSPLWIIGVLTLTGIAVGLVIRFSQGHAGPDPACEP-----LIGAPVPPSALPGLI 104
             A   P  I  V  +     G++  F   + G   A +           +        +
Sbjct: 92  TSAPGYPFMIPLVEGMAAFISGVLSYFMIKNPGSLGANKAIRAYHENPESLTLKEAFTTL 151

Query: 105 VALILGLAGGVSLGPEHPIMTVNIALAVAIGARLLPR-VNRMEWTILASAGTIGALFGTP 163
               + L  G   G E  +  V  ++ V I   L  +     E   +     +GA+F  P
Sbjct: 152 FTSAMVLGSGGPSGREGAVSMVGGSVGVFIAKLLRQKPHEVREALAIGVGAGLGAMFKAP 211

Query: 164 VAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDI 223
           +A A+  S+                   AAA   + T + F P F + +      E+  I
Sbjct: 212 LAGAIASSEIFFKHDFDIETIIPAFAASAAAYLVVATKVGFSPLFRIGVLPVHNFELRYI 271

Query: 224 LSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKG 283
           L  +I    +       +W    +  +  ++K P+ V  + G +L     +    ++  G
Sbjct: 272 LWFSIFGIFSGLIARFLLWVFYYISDLFKKLKQPIYVTALIGGVLAGCIGLLSSYAIGNG 331

Query: 284 LDEMQQMVANQAFSTSDYFLLAVI-KLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEH 342
              +Q ++ ++         L +I  + A+ + A SG  GG   P V +G   G +    
Sbjct: 332 YGWLQLIMDHKISPGVSELTLGIICVILAMSLIAGSGASGGAFSPTVVIGGLSGALFWHF 391

Query: 343 VPAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIV----MLPAWLLL 398
              V   + +  A+  +V      G +++F  A   P +T++ +  +     +L   +L 
Sbjct: 392 AKVVSPNLNIPIAMFVVV------GMMAVFSVAANAPLSTIVMITEMTGSYGVLLPAMLT 445

Query: 399 AGKPMM 404
            G  MM
Sbjct: 446 VGIAMM 451


>UniRef50_D1AKC6 Chloride channel core n=2 Tax=Fusobacteriaceae RepID=D1AKC6_SEBTE
          Length = 563

 Score = 94.4 bits (233), Expect = 7e-18,   Method: Composition-based stats.
 Identities = 67/408 (16%), Positives = 144/408 (35%), Gaps = 25/408 (6%)

Query: 7   RTMLLLSLPAVAIGIASSLILIVV---MKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVL 63
           +  LLL   ++  G  S  ++I+    +    +L+  L++ L      +  +    I + 
Sbjct: 19  KHNLLLIFYSLLTGTLSGAVVILYRLGLDKIGILREKLFENL------SVWNFCTGIFIF 72

Query: 64  TLTGIAVGLVIRFSQGHAGP-DPACEPLIGAPVPPSALPGLIV---ALILGLAGGVSLGP 119
            L G+ +  ++      +G   P  + L+   +    LP LI+     +L +  G+SLG 
Sbjct: 73  ILIGVILQFLVMKFPLISGSGIPQVKALLMQKIHFRWLPELILKFFGGLLSIGVGLSLGR 132

Query: 120 EHPIMTVNIALAVAIGARLLPRVNRMEWTI-LASAGTIGALFGTPVAAALIFSQTLNGSS 178
           E P + +   +   I           ++ I   ++  + A F  P+A  +   + L    
Sbjct: 133 EGPSIHLGALVGEGINEVTGRSEMEKKYFITCGASAGLAAAFNAPLAGVIFALEEL-HKF 191

Query: 179 EVPLWDRLFAPLMAAAAGALT-TGLFFHPHFSLPIAHYGQME-MTDILSGAIVAAIAIAA 236
             PL       + +  A  LT   L +HP F+  +    +   + +I    I   I    
Sbjct: 192 FSPLLLIC-TLIASITADFLTRIFLGYHPVFNFEVTAPTEFNSLMEIFLILIFGIIMSFM 250

Query: 237 GMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAF 296
           G +    L +   +  ++         G  ++              G + ++++      
Sbjct: 251 GKLFSDNLIKFQKVYKKIDLNPYFKAAGLMLIAFFTAFLFKDITGGGHNLIEKITQ-YPT 309

Query: 297 STSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPA------VPAAI 350
                FLL   K    +++ +SGF GG   P + +G  LG +    +        +    
Sbjct: 310 PVLILFLLLAGKFLYTLISYSSGFPGGIFLPMLVIGALLGKIYGIFIVNLFGVSDIYITH 369

Query: 351 TVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL 398
            +   +      V R     + +   +  N + L  L  +   ++++ 
Sbjct: 370 YIILGMAAYFTAVVRAPITGIILILEMTGNFSHLFALTFISAVSYIIT 417


>UniRef50_Q1YV59 Voltage-gated chloride channel family protein n=1 Tax=gamma
           proteobacterium HTCC2207 RepID=Q1YV59_9GAMM
          Length = 565

 Score = 94.4 bits (233), Expect = 7e-18,   Method: Composition-based stats.
 Identities = 57/313 (18%), Positives = 110/313 (35%), Gaps = 8/313 (2%)

Query: 90  LIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARLLPRVNRMEWTI 149
            +  P+         +A     +GG S+G   PI+     + + +   +  R++   +  
Sbjct: 97  QVNEPLDIKTGMASTLAAFASASGGGSVGQYGPIVHFGATMGIWVKRFISSRLSHEIYLG 156

Query: 150 LASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFS 209
              A  I A F  P+A  +   + +     V         + + +A AL    F H    
Sbjct: 157 CGVAAAISAGFNAPIAGVVFAHEAVLRHFSV--RAIAPITVASISASALGNQWFPHTTTF 214

Query: 210 LPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILG 269
              A    +     +   +  A A+ A                   +P+L+  I   I G
Sbjct: 215 DISATLPPLAEVVPVLVMLAPAFALVAICFMAALRYSAQTAAKMNTSPLLLPFIAATICG 274

Query: 270 ILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAV 329
           ++G +  P  L  G+  + +M+A + F+ S    + V KL    +    G  GG   P++
Sbjct: 275 LVG-VWIPQILGLGISSINEMIAGE-FALSLLLTVLVAKLLMTALCIGFGLFGGVFSPSL 332

Query: 330 FVGVALGLMLHEHVPA----VPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLP 385
           F+GVA G +  E +        A+I     +  +   V      ++ +   +  +     
Sbjct: 333 FIGVAAGAVAGELLILFGFGDIASIISVAGMAAVSSAVIGAPVSAVLIILELTQSYEYAV 392

Query: 386 LLCIVMLPAWLLL 398
              I ++   LL 
Sbjct: 393 AAMIAVMVCNLLT 405


>UniRef50_Q57753 Uncharacterized protein MJ0305 n=5 Tax=Methanocaldococcus
           RepID=Y305_METJA
          Length = 395

 Score = 94.4 bits (233), Expect = 7e-18,   Method: Composition-based stats.
 Identities = 66/328 (20%), Positives = 119/328 (36%), Gaps = 18/328 (5%)

Query: 16  AVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIR 75
           A  IGI   L        +SV+  ++ +  P    +     L I  V  + G+ V  +  
Sbjct: 22  ASLIGIVGGL--------SSVIIAIIIEYFPEKHNV-----LLIPIVFFIAGLFVDYIYE 68

Query: 76  FSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIG 135
                                   L  +++A  + +A G S G E P +  + + A  + 
Sbjct: 69  LKGSGIDRVLKALNTNEKLTWIRGLLKVLLAGAV-IAVGGSAGKEGPCVQSSASFADEL- 126

Query: 136 ARLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAA 195
            RLL   NR    I   AG +G  F  P+  A++  + +   +    +  L  P++A+  
Sbjct: 127 YRLLKLKNRELVIITGIAGGLGGAFSAPLGTAILACEIIEHENF--NYINLIPPIIASVV 184

Query: 196 GALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMK 255
           G L   L         I     + + D L   + A          +    ++ +    +K
Sbjct: 185 GYLIFYLITGRKHLFNITLSYTINIHDFLLFILGAFFCSLIAHCYIKTYRKISSTFDNLK 244

Query: 256 NPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVA 315
            P  +  + G IL  +     P  +  GL   +++     FS     LL + K+ A    
Sbjct: 245 IPYCIKTLIGGILVAVISYFIPEVMGMGLTLTKELFI-MEFSLVFLVLLLIGKILATSFT 303

Query: 316 AASGFRGGRIFPAVFVGVALGLMLHEHV 343
             SG  GG +FP++ +G   G++    +
Sbjct: 304 VGSGTPGGLVFPSMCIGAISGIIFGSLI 331


>UniRef50_UPI000174564F putative voltage-gated ClC-type chloride channel ClcB n=1
           Tax=Verrucomicrobium spinosum DSM 4136
           RepID=UPI000174564F
          Length = 522

 Score = 94.1 bits (232), Expect = 8e-18,   Method: Composition-based stats.
 Identities = 67/319 (21%), Positives = 119/319 (37%), Gaps = 15/319 (4%)

Query: 84  DPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARLLPR-V 142
                 L    +P  A     ++ ++ +A G S+G E P++ +    A  +G        
Sbjct: 39  YMEAIALGDGNIPIRASLMKSLSALVSIASGASIGREGPLVQLAAMAASTLGRLWKSGMA 98

Query: 143 NRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGL 202
            R       +A  I + +  P+  A+  ++ + G+     ++ L   L ++     T   
Sbjct: 99  QRRLLVACGAAAGIASAYNAPLTGAMFVAEVVLGTLA---FETLGPLLFSSVVATATVRH 155

Query: 203 FFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPV-LVL 261
            F       +        T + +   V   A A G + +  L     +    + PV L L
Sbjct: 156 VFGEAALYQVEVLNAGGATALPAHLGVGIAAGAVGPLFLVVLRWGTRLFVIAEWPVPLRL 215

Query: 262 GIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFR 321
            +GGF++G+L     P     G   +  M+           + A++KL A V   +SG  
Sbjct: 216 AVGGFMVGLLAA-WHPQVCGNGSHLLNDMLHAPPELGL-LVVYALLKLTATVTTFSSGAV 273

Query: 322 GGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNT 381
           GG   P +F+G ALG + H  + A    + V    L IV        +  F+AA      
Sbjct: 274 GGVFTPTLFLGAALGQICHVAIHAAFPGLAVPAGALAIV-------GMGAFLAATTHAPV 326

Query: 382 TLLPLLCIVMLPAWLLLAG 400
           T + L+   M   + L+  
Sbjct: 327 TAI-LMVFEMTLDYPLVLP 344


>UniRef50_A4E742 Putative uncharacterized protein n=3 Tax=Collinsella
           RepID=A4E742_9ACTN
          Length = 473

 Score = 94.1 bits (232), Expect = 8e-18,   Method: Composition-based stats.
 Identities = 64/396 (16%), Positives = 136/396 (34%), Gaps = 23/396 (5%)

Query: 17  VAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIR- 75
           + + +A  +     +   ++  +             ++   WI  +L + G+A   V + 
Sbjct: 68  IIVSLAMGVAAWAFLASLNIATDY------------RERHAWIYALLPVVGMATAWVYKN 115

Query: 76  --FSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVA 133
              +            L    +         V   L    G S G E   + +   +A  
Sbjct: 116 HGLAAKRGNNLVIDSALGTRLIHMRMAVLTFVCSTLTHLTGGSAGREGAAVQIGGTIASN 175

Query: 134 IGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMA 192
           I +   L + +  +  +   +   GA+FG+P+A A    +          +      L+A
Sbjct: 176 ISSLAHLKKHDHHDLMLAGISSAFGAVFGSPLAGAFFGME--MCFIGKIDYTAGIYCLVA 233

Query: 193 AAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMH 252
           +  G  T+      + +  IA    M    ++   I A I      +  W +  + ++  
Sbjct: 234 SFTGYFTSLALGTEYEANVIASVPGMTPKTVVIVVISAIIFGLTARLFAWSVRTVKSLYG 293

Query: 253 QMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAAL 312
           ++    LV  + G ++ +          + G   +   ++   F+ +   + A IKL   
Sbjct: 294 RIITNYLVRALVGALVVLAAYAMLGAWKYAG---LATWLSGAGFAGNTTLVDAAIKLVVT 350

Query: 313 VVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLVVTRDGWLSLF 372
            +   +GF+GG + P   +G ALG  +   V   P+ +  +  +LG+          +  
Sbjct: 351 ALTLGAGFQGGEVTPLFGIGAALGGWIGCLVGIDPSFLA-ALGMLGVFCAGLNVPITTCM 409

Query: 373 MAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNR 408
           MA  +   T       IV   ++L    + +    R
Sbjct: 410 MAIDLFHGTAA-GFFVIVAFISYLTGGHRGVYPAQR 444


>UniRef50_Q0TQI9 Voltage-gated chloride channel family protein n=14 Tax=Clostridia
           RepID=Q0TQI9_CLOP1
          Length = 523

 Score = 94.1 bits (232), Expect = 9e-18,   Method: Composition-based stats.
 Identities = 73/408 (17%), Positives = 165/408 (40%), Gaps = 17/408 (4%)

Query: 1   MLHPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWII 60
           +L  R      L L   AIG+  SL+L++   I + L   L+++L     ++  + + ++
Sbjct: 9   VLSHRKDLRFKLVLEGAAIGLLCSLVLVLNRIIVNYLFP-LFKKLYAWAALSITNMIIVL 67

Query: 61  GVLTLTGIAVGLVIRFSQGHAGP-DPACEPLIGAPVPPSALPGLI---VALILGLAGGVS 116
            +L + G  VG ++R     +G   P  E  +   +  + L  LI   +  ++ L  G+S
Sbjct: 68  VILAILGALVGFMVRREPMISGSGIPQVEGELIGKLKMNWLKILIYKFLGGVISLGAGLS 127

Query: 117 LGPEHPIMTVNIALAVAIGARLLPR-VNRMEWTILASAGTIGALFGTPVAAALIFSQTLN 175
           LG E P + +  A+       L    + +       ++  + A F  P++  +   + ++
Sbjct: 128 LGREGPSVQMGAAVGEGFSNGLKRINIEKKYLITSGASAGLAAAFNAPLSGVIFALEEVH 187

Query: 176 GSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIA 235
            S        L + + A+      +  F   + SL I +   + +       I+  I   
Sbjct: 188 KSFS---PLVLVSAMAASLVSDFVSKQFLGMNPSLGIENVPVLPLKYYWVLIILGVILGI 244

Query: 236 AGMVAVWCLPRLHAMMHQMKN-PVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQ 294
            G +    + ++ ++  + KN PV V  +  F+L  +  I  P+ L  G + +  +    
Sbjct: 245 GGAIFSKGILKVQSLYGKFKNVPVEVKVMIPFLLTGILGIFAPIILGGGHELIMDLATK- 303

Query: 295 AFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEH------VPAVPA 348
           +F       + ++K    +++  +G  GG  FP + +G  +G ++         VP    
Sbjct: 304 SFPIKLLLAVLLVKFLLTIISFGAGTPGGIFFPLLLLGAVVGNIVGIVSCNAFGVPNQYI 363

Query: 349 AITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWL 396
              +  A+ G    + +     + +   +  +   +  L +V++ +++
Sbjct: 364 IDFIILAMAGNFASIVKAPITGIILITEMTGSFEHMLALSVVVIISYV 411


>UniRef50_C6JKX7 Chloride channel protein n=5 Tax=Fusobacterium RepID=C6JKX7_FUSVA
          Length = 524

 Score = 94.1 bits (232), Expect = 9e-18,   Method: Composition-based stats.
 Identities = 57/372 (15%), Positives = 120/372 (32%), Gaps = 24/372 (6%)

Query: 67  GIAVGLVIRFSQGHAGP-DPACEPLIGAPVPP----SALPGLIVALILGLAGGVSLGPEH 121
           G+ V L+ +     +G   P  + +I   +        L    +  + G+  G+SLG E 
Sbjct: 76  GLLVDLIAKKYPKTSGSGIPQVKGIILRQLDYVKWFQELIAKFIGGLFGIGCGLSLGREG 135

Query: 122 PIMTVNIALAVAIGARLLP-RVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEV 180
           P + +   +   +        V +       ++  +   FG P+A  +   + L+     
Sbjct: 136 PSVQLGSYIGYGVTKIFKRDSVEKKYLVTSGASAGLAGAFGAPLAGVMFSLEELHKFIS- 194

Query: 181 PLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAA---G 237
                L    +A+ A        F    +  +      E+       +     I     G
Sbjct: 195 --SKLLICTFLASIASDFVGRRIFGMQTAFNLTVNYPKEINPYFQFGLFVCFGIVIAFFG 252

Query: 238 MVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFS 297
            +    L ++  +    K P             +     P     G + +++M      +
Sbjct: 253 KIFTMTLVKIQDIYKGAKLPRWAKVSFVMTTSFILCFILPEVTGGGHELVEEMAGGNR-T 311

Query: 298 TSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAV----PAAIT-- 351
                ++ V+KL    ++ A+GF GG   P + +G  LG +    +  +    P  I   
Sbjct: 312 IKLLVIIFVVKLLFTALSYATGFAGGIFLPMLVLGAILGKIYGILLVNILGVGPEFIPHY 371

Query: 352 VSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL-----AGKPMMMV 406
           +   + G  + V R       +   +  N   L  L  V + A+ +           ++ 
Sbjct: 372 MVLGMAGYFVAVVRAPITGAVLILEMTGNFDHLLALVTVSVIAYYITDLLGLEPIYEILY 431

Query: 407 NRPKQQPPHDNV 418
            +  +  P + V
Sbjct: 432 EKMAKDVPSEKV 443


>UniRef50_B5JKG4 Chloride transporter, ClC family, putative n=1 Tax=Verrucomicrobiae
           bacterium DG1235 RepID=B5JKG4_9BACT
          Length = 627

 Score = 94.1 bits (232), Expect = 9e-18,   Method: Composition-based stats.
 Identities = 83/414 (20%), Positives = 158/414 (38%), Gaps = 30/414 (7%)

Query: 14  LPAVAIGIASSLILIVVMKIASVLQN---LLWQRLPGTLGIAQDSPLWIIGVLTLTGIAV 70
           + A+ IGI S L  +   K     ++       ++PG LG+     L +I +    G+ V
Sbjct: 65  VLAILIGILSGLSAVAFHKSIHWAEHNWIYRVSQIPGWLGV-----LGLIFLPAFGGLVV 119

Query: 71  GLVIRF-----SQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMT 125
           G +I++     +        A   L    +   A  G  +     +  G SLG E P + 
Sbjct: 120 GFLIKYWAPEAAGSGIPQVKAAYFLKFGRIRFRAALGKFILGTASIGTGASLGREGPTVH 179

Query: 126 VNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSE-VPLW 183
           ++ A+A  +G    L     M    L  AG I A F TP+AA +   + + G  +     
Sbjct: 180 LSAAIASWVGRWFGLAPRQVMALIPLGCAGGIAAAFNTPLAAIVFAIEEIMGDLKHKAFA 239

Query: 184 DRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWC 243
             +   ++AA      + L     F +P  H   +    +    ++  IA       V C
Sbjct: 240 GIVMVAVIAAVIER--SLLGTDAMFQVPF-HPDHLSGLGLAMSLVLGVIAGFVSHAFVEC 296

Query: 244 LPRLHAMMH--QMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDY 301
           + +    +   + K   ++ G+GG + G +G +        G+  +  +  ++A + S  
Sbjct: 297 MLKARERVKLVRGKYSWMMPGVGGLLTGCVGALVFKNLGHMGVFGIGYLDLSEALAGSLS 356

Query: 302 FLLAVI----KLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAIL 357
             + V     K A+ + + +SG  GG   P +F+G  LG  L      V     +   +L
Sbjct: 357 LGVLVALFVGKFASTIFSYSSGGSGGIFAPTLFIGAMLGGALGVLTEMVSGQAGLLPHVL 416

Query: 358 GIV------LVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMM 405
            +V        V R    S+ +   +  +  L+  + +  L ++ + +    + 
Sbjct: 417 ALVGMGALFAGVIRAPVTSILIIFELTRDYNLILPIMVANLTSYAIASKLRQVP 470


>UniRef50_Q0EW01 Cl-channel, voltage gated n=1 Tax=Mariprofundus ferrooxydans PV-1
           RepID=Q0EW01_9PROT
          Length = 598

 Score = 94.1 bits (232), Expect = 1e-17,   Method: Composition-based stats.
 Identities = 78/399 (19%), Positives = 145/399 (36%), Gaps = 26/399 (6%)

Query: 5   RARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLT 64
           R +  + + L AV IGI S    +++      +             I        +   T
Sbjct: 19  RQQDTVFMVLLAVVIGILSGYAALLLRFAIEWVSLFWTGERTWEDAITTLPWYIYLLAPT 78

Query: 65  LTGIAVGLV-IRFSQG----HAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGP 119
           +TG+ V  + IRF             A        V    L   +    L + GG SLG 
Sbjct: 79  ITGLIVAWISIRFLPEGELRDVAGVLADMVERRGRVRSRLLATELAGSALAMGGGASLGR 138

Query: 120 EHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSS 178
           E P + +   +A  IG RL +            +A  I A F TP+A AL   + +    
Sbjct: 139 EGPTVALGALIASEIGQRLDMSEQQLRILIGCGAAAGIAASFNTPIAGALFALEVVLADY 198

Query: 179 EVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGM 238
            +  +      ++A+    +          +  +  Y  +   +I +  ++ AI      
Sbjct: 199 AIATFS---PIVIASVLATVIARSEVGNFPAFTVPEYHLISTWEIPAYILMGAICGLVAT 255

Query: 239 VAVWCLPRLHAMMHQM-KNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFS 297
           V +  +      + ++  N ++   + GF++G++G++  P  +  G   ++ M+      
Sbjct: 256 VLIKSMTPTRIFLTRLIPNRLIRPAVVGFVVGLMGLM-LPQIMSIGYGTVESMMLEHVDP 314

Query: 298 ---------TSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPA 348
                         +L + KL A ++ AA GF GG   P +F+G  +G +      A   
Sbjct: 315 HLMGYLVPLVLFLAVLLIGKLVATILCAAGGFPGGLFGPVLFLGAVVGALFGGVAHAYSP 374

Query: 349 AITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLL 387
           + + S     +V         +L  AA+  P T +L + 
Sbjct: 375 SYSESSGAYALVAC------GALTAAALQAPLTVMLIVF 407


>UniRef50_D1CB35 Chloride channel core n=6 Tax=Bacteria RepID=D1CB35_THET1
          Length = 606

 Score = 94.1 bits (232), Expect = 1e-17,   Method: Composition-based stats.
 Identities = 76/402 (18%), Positives = 152/402 (37%), Gaps = 11/402 (2%)

Query: 4   PRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVL 63
           PR   +  L++    +G   +LIL+ ++   + L                   L ++ V 
Sbjct: 30  PRLIYISALAIIVGIVGAFLALILLYLIHFFTSLFFFQRISFQDVSPSRNHLGLAVLFVP 89

Query: 64  TLTGIAVGLVIRFS----QGHA-GPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLG 118
            + GI VGL+ R+     +GH          + G+ V P       V+  + +  G   G
Sbjct: 90  VIGGIIVGLMARYGSEKIRGHGIPEAIEAILINGSKVEPRLAILKPVSSAITIGSGGPFG 149

Query: 119 PEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGS 177
            E PI+    A    I   L L    R    +  +A  + A+FG P+AA  +  + L   
Sbjct: 150 AEGPIIMTGGAFGSLIAQLLRLSSSERKTLLVAGAAAGMAAVFGAPLAAIALAVEVL--L 207

Query: 178 SEVPLWDRLFAPLMAAAAGAL-TTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAA 236
            E      +   + +A AGAL    L   P F  P   +    M  +        +A   
Sbjct: 208 FEWRPRSLIPVAISSAIAGALRYYLLGTPPIFPTPTHTFYPTLMVLVDCFIT-GLVAGLL 266

Query: 237 GMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAF 296
            ++  W +  +  +  ++    +     G +   +G +  P +L  G D +  M+  Q  
Sbjct: 267 SLILTWMVYTVEDIFRKLPVHWMWWPAIGGVFVGIGGLIYPRALGVGYDVIADMLRGQN- 325

Query: 297 STSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAI 356
           +      + ++K A   +A  SG  GG + P + +G ++G++     P++        ++
Sbjct: 326 TWQLILGILLVKSAIWAIALGSGTSGGVLAPILMIGGSIGIIESHIFPSMGEGFWPMLSM 385

Query: 357 LGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL 398
             ++    R    ++  A  +  +   +  L +V++ ++   
Sbjct: 386 SAVLGGAMRAPLTAIIFALELTHDIHSVIPLILVVIVSYGFT 427


>UniRef50_C9RMG0 Cl-channel voltage-gated family protein n=1 Tax=Fibrobacter
           succinogenes subsp. succinogenes S85 RepID=C9RMG0_FIBSS
          Length = 456

 Score = 94.1 bits (232), Expect = 1e-17,   Method: Composition-based stats.
 Identities = 74/395 (18%), Positives = 134/395 (33%), Gaps = 23/395 (5%)

Query: 16  AVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIR 75
           A  IG  + L+ +          +  W R+P TLGI          V  + G+ VGL I 
Sbjct: 24  AAVIGFVTGLVAVAFHWGLERAVD--WVRMPWTLGI--LPWYAFAAVPAIGGLVVGLFIH 79

Query: 76  FSQGHAGPDPACEPLI-------GAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNI 128
                          +       G  V     P    A I+ LA G S G E PI  +  
Sbjct: 80  KVARAPETAGQGTDKMIYSFHHQGGNVRARVAPVKFFASIITLATGGSAGYEGPISQIGS 139

Query: 129 ALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLF 187
            +A  I     +PR+ R ++ +  +A  +GA+F  P+A AL  S  +    +        
Sbjct: 140 GIASTICKFFKMPRMMRGQFLLAGTAAGLGAIFKAPLAGALT-SVEMLYREDFESNAFAT 198

Query: 188 APLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRL 247
           + + +  + A+             +  +      ++L+ A++  +      + V      
Sbjct: 199 SIVSSVVSFAVYVAFVGTAPLIGGVPAFPFTGGVELLACALLGVLCFPFSYLYVRFYYES 258

Query: 248 HAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVAN----QAFSTSDYFL 303
                +   PV +    G     L V+  P     G D +  ++A       +       
Sbjct: 259 ERRFSKWAVPVWLKPALGGAFISLLVLAYPEVSGGGFDFIDNLMAGLVPHSMWGVLLLLG 318

Query: 304 LAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAV------PAAITVSCAIL 357
           + + K+ A  +   SG  GG   P++F+G  +G M                 + +   + 
Sbjct: 319 IVLAKIVATALTVGSGGSGGVFGPSLFIGGVIGAMFAGICELAFPGVIRMPEMFILVGMA 378

Query: 358 GIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVML 392
                  +     + M   +  + +LLP L I  +
Sbjct: 379 SFFAGAAKAPIAGVVMVCEMTGSYSLLPGLLIASV 413


>UniRef50_B1ZT36 Chloride channel core n=1 Tax=Opitutus terrae PB90-1
           RepID=B1ZT36_OPITP
          Length = 591

 Score = 94.1 bits (232), Expect = 1e-17,   Method: Composition-based stats.
 Identities = 72/404 (17%), Positives = 134/404 (33%), Gaps = 28/404 (6%)

Query: 2   LHPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLW--- 58
           L P    + L    A   G   +L  ++   +   +  LL  R  G +   +  P W   
Sbjct: 29  LQPTEWQITLWW--AALAGFVGALSSLLFSVLTEGIHELLTGRSDGVVETMRQLPWWACV 86

Query: 59  --IIGVLTLTGIAVGLVIRFSQGHAGPD-PACEPLIGAPVPPSALPGLIVALILGLAGGV 115
                   L G  + L  R SQG +  D      +    +P  +      A +  +  G 
Sbjct: 87  AVPATGGLLAGATLLLGKRLSQGQSSTDYMEAIAIGSGRIPVRSSLLKSAAALFSIGSGG 146

Query: 116 SLGPEHPIMTVNIALAVAIGA-RLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTL 174
           S+G E P++ +    A  +G  R              +A  I + +  P+A +   ++ +
Sbjct: 147 SIGREGPMVQLAALQASMLGRWRRFSPPQLRLLVACGAASGIASAYNAPIAGSFFVAEII 206

Query: 175 NGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAI 234
            G+  +   + L    ++A A ALT  +         +       +           +  
Sbjct: 207 LGTIAM---ESLGPLAVSAVAAALTVRVLTDAQ---HLYQVPAFRLDSPWEMLPYVMLGF 260

Query: 235 AAGMVAVWCLPRLHAMMHQMKN----PVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQM 290
             G +A W L  L             P+  L +GG ++G + +   P     G   +   
Sbjct: 261 IEGTLAPWFLRSLRRAEKLFVVTTIPPIARLVLGGMLVGGIAIF-FPQVAGNGY-TVVLE 318

Query: 291 VANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGL----MLHEHVPA- 345
           + N          + + K  A   +  SG  GG   P++F+G + G      +H   PA 
Sbjct: 319 ILNGQVVWLALVGIMIAKWLATASSFGSGAPGGVFTPSLFMGASAGYLFGTAVHSFWPAG 378

Query: 346 --VPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLL 387
              P A  +      +           + +  + +    +LPL+
Sbjct: 379 APDPQACALVGMGAFLSAASYAPVMAIIMLFEMTLSYDIILPLM 422


>UniRef50_C1F1A6 Chloride transporter, ClC family n=1 Tax=Acidobacterium capsulatum
           ATCC 51196 RepID=C1F1A6_ACIC5
          Length = 472

 Score = 93.7 bits (231), Expect = 1e-17,   Method: Composition-based stats.
 Identities = 73/420 (17%), Positives = 144/420 (34%), Gaps = 25/420 (5%)

Query: 6   ARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTL 65
           +R ++   + A  +G+ + L++ +   IA V+   +W   P  LG+    P  I+  L L
Sbjct: 46  SRDLIKWLIAAPLVGVITGLLITL---IAVVILKGIW---PPVLGLYLHHPWTILPGLLL 99

Query: 66  TGIAVGLVIRFSQGHAGPDPACEP-----LIGAPVPPSALPGLIVALILGLAGGVSLGPE 120
            G+  GL++++   +       E           +   +    ++A I  +  G S   E
Sbjct: 100 CGLLTGLIMQWFTPNPDEHSTEEVIRSYHEHSGRMNLRSFVPKLIAAITTVGLGGSAALE 159

Query: 121 HPIMTVNIALAVAIGARL-----LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLN 175
            P +    A+   +  RL     L   +R    I  +A  + A+F  P+   +   +   
Sbjct: 160 GPSIYGGGAVGSLLWTRLQKRLRLTGTDRRILLICGAAAGMSAVFRAPLTGIVFALE--M 217

Query: 176 GSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIA 235
              +    + L   L+A+     T                      D+   A++  +   
Sbjct: 218 PYKDDLAHEALVPSLIASVVSYATLASILGSQPLFGFHSAVTWRDADLAWCALLGLLVGL 277

Query: 236 AGMVAVWCLPRLHAMMHQMKNP-VLVLGIGGFILGI-----LGVIGGPVSLFKGLDEMQQ 289
                V    R      Q + P  + L +G F  G+     L +  GP+       E   
Sbjct: 278 VATAFVTTFRRARRWFVQWRRPHWIKLTLGSFATGLCGFAFLALYRGPLVPLGANYEAVG 337

Query: 290 MVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVP-AVPA 348
           ++ +Q  S+ +  + +V+KLAA +   A+G       P    G ALG    + V  +   
Sbjct: 338 ILLHQHHSSLELLVFSVLKLAATLFTLAAGGVSAMFVPLFLTGGALGTAFAQSVAHSSAP 397

Query: 349 AITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNR 408
            +  +  +   +    +    ++   A        L    I    A+++          R
Sbjct: 398 ELYAAVGMASFIAAGYKTPLAAVVFVAEATGAHAFLIPALIGAAVAYVVSGDASASGDQR 457


>UniRef50_C7H8M0 Voltage-gated chloride channel family protein n=2
           Tax=Faecalibacterium prausnitzii RepID=C7H8M0_9FIRM
          Length = 426

 Score = 93.7 bits (231), Expect = 1e-17,   Method: Composition-based stats.
 Identities = 51/247 (20%), Positives = 89/247 (36%), Gaps = 7/247 (2%)

Query: 92  GAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTIL 150
           G PV P  +P + +  +L    G S G E   + +  ++   +G  L L    R   TI 
Sbjct: 91  GEPVSPLLVPAIFLGTVLTHLCGGSAGREGAALQMGGSIGWNVGKLLHLSDYVRRTATIS 150

Query: 151 ASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSL 210
             A    ALFGTP+ AAL      +    +           +A      +  F     + 
Sbjct: 151 GMAAFFSALFGTPLTAALFAMMVED--VGLTFTSAFMPAFTSALIAYGVSLFFGIAPTNF 208

Query: 211 PIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRL-HAMMHQMKNPVLVLGIGGFILG 269
            +     + +   L  A++     A   +  W L  L H +  ++ NP L    G     
Sbjct: 209 VLNSIPHLTLETALQTALLGIACAAVTRLFCWTLHTLEHGIPKRIPNPWLRAFAG-GAAV 267

Query: 270 ILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAV 329
           +       V  + G      ++A+     +      + K+    +  A GF+GG + P+ 
Sbjct: 268 VAFSYLFGVGRYNGAGM--AVIADAVEQGAALPWDFLCKIFLTALTLAVGFKGGEVVPSF 325

Query: 330 FVGVALG 336
           ++G   G
Sbjct: 326 YIGATFG 332


>UniRef50_C3X6F3 Chloride channel protein n=2 Tax=Oxalobacter formigenes
           RepID=C3X6F3_OXAFO
          Length = 459

 Score = 93.7 bits (231), Expect = 1e-17,   Method: Composition-based stats.
 Identities = 70/368 (19%), Positives = 124/368 (33%), Gaps = 24/368 (6%)

Query: 49  LGIAQDSPLWIIGVLTLT-GIAVGLVIRFSQGHAGP-DPACEPLIGAP--------VPPS 98
             I    P   I  + +   + V +  RF  G  G   P    +I  P        +   
Sbjct: 66  TWIVTHVPWASIIYMPVGFALIVYIARRFFPGTQGSGIPQTIAVIDDPDHKKKSDLLSLK 125

Query: 99  ALPGLIVALILGLAGGVSLGPEHPIMTVNIAL--AVAIGARLLPRVNRMEWTILASAGTI 156
            L G I  L+ GL  G S+G E P + V  ++  A      L     R    +   A  I
Sbjct: 126 ILFGKIAMLLGGLTLGASIGREGPTVQVGASIMHAFYGYGTLKTAEQRRMLALSGGAAGI 185

Query: 157 GALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYG 216
            A F TP+A  +   + L               L+      L +      +      +  
Sbjct: 186 AAAFNTPMAGIMFAMEELTKKYIFNAHS---PTLLTVILSGLISIALVGNYTYFGYTNES 242

Query: 217 QMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQ------MKNPVLVLGIGGFILGI 270
              +T+I +  +        G +    + ++     Q       ++P+      G I+ I
Sbjct: 243 LALLTNIPAILVCGIAGGVIGGLFSLIVQKISVTPPQRIKKVIQEHPLAFAAACGLIVAI 302

Query: 271 LGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVF 330
           LG++        G  +  ++      +   ++     K  A +V+  SG  GG   P + 
Sbjct: 303 LGLLTDGTVYGTGY-QPTRLTLESDTTFLVWY-YGAAKFIATLVSTLSGIPGGLFAPTLS 360

Query: 331 VGVALGLMLHEHVPAV-PAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCI 389
           VG  +G  ++   P + P    +   +   +  VTR    S  +   +  +  +L  L  
Sbjct: 361 VGAGIGDNVYALFPGLAPHGAIIILVMAAYLSGVTRSPLTSFIITMEMTGSHQMLLSLMA 420

Query: 390 VMLPAWLL 397
           V L A L+
Sbjct: 421 VSLLASLV 428


>UniRef50_A2BL36 Conserved archaeal protein n=1 Tax=Hyperthermus butylicus DSM 5456
           RepID=A2BL36_HYPBU
          Length = 619

 Score = 93.7 bits (231), Expect = 1e-17,   Method: Composition-based stats.
 Identities = 66/387 (17%), Positives = 124/387 (32%), Gaps = 32/387 (8%)

Query: 59  IIGVLTLTGIAVGLVIRFSQ---GHAGPDPACEPLIG--APVPPSALPGLIVALILGLAG 113
           I  +L +  +A  L++   +      G D A          + P       VA  + L  
Sbjct: 88  IPVILGVGALAASLIVYKFEPEAAGGGTDAAVYAYHHRAGIMRPRVAIVKAVASAILLGT 147

Query: 114 GVSLGPEHPIMTVNIALAVAIGARLLPR-VNRMEWTILASAGTIGALFGTPVAAALIFSQ 172
           G S GPE P + +  A   +I   L    V R    +   A  +  +F +PV +A+   +
Sbjct: 148 GGSAGPEGPSIQIGGAAGSSIAKYLGMGVVERKIMLVAGMAAALSFIFQSPVGSAIFAVE 207

Query: 173 TLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQM----EMTDILSGAI 228
            L         + L   L A+      +     P + LP      +     +  + S  +
Sbjct: 208 VLYMRDME--LNALIPALFASIISYSLSLHILGPGYKLPSLAIDSLSRMYSLDVLASYIL 265

Query: 229 VAAIAIAAGMVAVWCLPRLHAMMHQMKN----PVLVLGIGGFILGILGVIGGPVSLFKGL 284
           +         + V+   R   +  ++      P  +  + G +L  +     P  L  G 
Sbjct: 266 LGLFTAPFAYMYVYVFTRTRRVFEKLHREHRIPQWIGPVIGALLVGVIGAFVPHVLGTGE 325

Query: 285 DEMQQMVANQAFSTSDYFLLAV-------------IKLAALVVAAASGFRGGRIFPAVFV 331
           + +  M+           +                +K+    +   SG  GG + P +F 
Sbjct: 326 ELLSLMLEGFQQGEMPGLVRLFGDSLLLTALLLAILKIVVTSLTVGSGGSGGLLAPGLFA 385

Query: 332 GVALGLMLHEHV---PAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLC 388
           G  +G +    V     +P  +     +  +    ++      F  A +     L+    
Sbjct: 386 GAMIGEVFGLIVHDYTGIPPGVYAYLGMASLFGAASKVSVGLSFFVAEIGGTPALVVPAL 445

Query: 389 IVMLPAWLLLAGKPMMMVNRPKQQPPH 415
           I  L A L L    ++    P + PP 
Sbjct: 446 ISSLTASLALGNVSIVESQLPHKVPPA 472


>UniRef50_B9GHY7 Cl-channel clc-3 n=5 Tax=Magnoliophyta RepID=B9GHY7_POPTR
          Length = 568

 Score = 93.3 bits (230), Expect = 1e-17,   Method: Composition-based stats.
 Identities = 56/303 (18%), Positives = 114/303 (37%), Gaps = 23/303 (7%)

Query: 105 VALILGLAGGVSLGPEHPIMTVNIALAVAIGARLLPRVNRME-WTILASAGTIGALFGTP 163
           +   + L  G SLGPE P + +  + A      +     RM       +A  I + F  P
Sbjct: 36  IQAAVTLGTGCSLGPEGPSVDIGKSCAHGFSLMMANNRERMNTLIAAGAAAGISSGFNAP 95

Query: 164 VAAALIFSQT----LNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQME 219
           VA      +T    L+  +  P    +   L+A+   +  +        +  +  Y    
Sbjct: 96  VAGCFFAIETVLRPLHAENSPPFTTAM--ILLASVISSTVSNTLLGTQSAFTVPSYDLKS 153

Query: 220 MTD----ILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMK-NPVLVLGIGGFILGILGVI 274
             +    ++ G +   +++A   +  W       +  +   +PV    +GG   GI+ + 
Sbjct: 154 AAELPLYLILGMLCGVVSVAFTRLVTWFTKSFEFIKEKFGLHPVACPALGGLGAGIIALK 213

Query: 275 GGPVSLFKGLDEMQQMV--ANQAFSTSDYFL--LAVIKLAALVVAAASGFRGGRIFPAVF 330
             P  L+ G   +++++     A +   + L  LA  K+ A  +   S   GG   P++ 
Sbjct: 214 Y-PGILYWGFTNVEEILHTGKSASAPGIWLLTQLAAAKVVATALCKGSLLVGGLYAPSLM 272

Query: 331 VGVALGLMLHEHVPAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIV 390
           +G A+G +         +A  +  + +     V +    +L   A  + +   +PL  I+
Sbjct: 273 IGAAVGAVFGG------SAAELINSAIPGNAAVAQPQAYALVGMAATLASVCSVPLTSIL 326

Query: 391 MLP 393
           +L 
Sbjct: 327 LLF 329


>UniRef50_Q2JJR6 Chloride transporter, chloride channel family n=2 Tax=Synechococcus
           RepID=Q2JJR6_SYNJB
          Length = 623

 Score = 93.3 bits (230), Expect = 1e-17,   Method: Composition-based stats.
 Identities = 70/317 (22%), Positives = 118/317 (37%), Gaps = 20/317 (6%)

Query: 100 LPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGA 158
           +P  ++A  + L  G SLGPE P +     L   +G  L L R          +A  + A
Sbjct: 113 IPLKLLAAAISLGAGASLGPEAPSVESGALLGSLLGQNLRLSRERVQLLMAAGAAAGLAA 172

Query: 159 LFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQM 218
            F  P+A   +  +     +       +       +A     GL   P F LP       
Sbjct: 173 GFNAPIAGVFLALELALARTFTTSAVSVVVLAAVVSALIAQVGLGAQPAFLLPTITQPAF 232

Query: 219 EMTDI-----LSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKN------PVLVLGIGGFI 267
            + D      L   +   +   A +V++     L    H   +      P     I G  
Sbjct: 233 VLPDYEIHSLLEVPLYLGLGFLASLVSMAFSYTLEWGKHLFNSGPLAAWPAWSKPILGGG 292

Query: 268 LGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFP 327
           +     +G P++L  G + ++ ++    FS     LL + KL    ++  SGF GG   P
Sbjct: 293 ILGCAGLGIPLALGVGYETIESILQAVPFSLGHLGLLLLGKLLLSALSLGSGFVGGTFAP 352

Query: 328 AVFVGVALGLM----LHEHVPAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTT- 382
           A+F+G  LG      L + +P +  +   + A++G+  V+       L    ++   T  
Sbjct: 353 ALFMGAVLGAGYGQVLSQALPLIALSPPAAYAMVGMAAVLAASVRAPLTAILLLFEMTRD 412

Query: 383 ---LLPLLCIVMLPAWL 396
               LP++  V L  WL
Sbjct: 413 YHIALPVMAAVGLSIWL 429


>UniRef50_C5VMQ7 Putative chloride channel n=1 Tax=Prevotella melaninogenica ATCC
           25845 RepID=C5VMQ7_9BACT
          Length = 598

 Score = 93.3 bits (230), Expect = 1e-17,   Method: Composition-based stats.
 Identities = 67/419 (15%), Positives = 139/419 (33%), Gaps = 34/419 (8%)

Query: 8   TMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTG 67
              L+ + A AIG+ +SL   ++  I  +++ L+         I     ++ I  + LT 
Sbjct: 23  NRELVLVLAFAIGLLASLAAYILHFIIKLIEELVTSGF-DVATINWLYLIYPIVGIWLTS 81

Query: 68  IAVGLVIRFSQGHA-GPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTV 126
           + V  V+R +  H             + +        IVA  + +  G S+G E PI+  
Sbjct: 82  LFVKYVVRDNISHGITRVLYAISTKQSRLKAHNTWSSIVASAITIGFGGSVGAEAPIVLT 141

Query: 127 NIALAVAIGARLLPRVNRMEWTILASAGT--IGALFGTPVAAALIFSQTLNGSSE-VPLW 183
             A+   +G R+    NR    ++    T  +  +F  P+A  +   + L        L 
Sbjct: 142 GSAIGSNLG-RIFNLDNRTLMLLVGCGATAAVSGIFKAPIAGLVFTLEVLMVDLTMASLL 200

Query: 184 DRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWC 243
             L A + A       TG      F   + +   ++        ++        +  +  
Sbjct: 201 PILIASVTATCFSYFFTG--GSSMFHFQMDNIWGLDRVPP--TILLGIACGFVSLYFMRL 256

Query: 244 LPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVAN---------- 293
           +        ++ +   +  + G ++    +   P    +G D ++  +            
Sbjct: 257 MSWCENGYGKLSSKPYLKLLVGGLVLSPLIFLFPSLYGEGYDSLRLFIEGKTEADWMQIM 316

Query: 294 --------QAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPA 345
                     F      L+ + K+ A      +G  GG   P++F+G   G         
Sbjct: 317 SGSMFAEKSNFLLLYVGLVVMTKVFATSATNGAGGCGGTFAPSLFIGGFGGFFFARFWNM 376

Query: 346 ------VPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL 398
                 +P        +  ++  V       +F+ A +     L   L IV + ++L +
Sbjct: 377 EQLGVYIPEKNFTLYGMAAVMSAVMHAPLTGIFLIAELTGGYQLFIPLIIVTISSYLTI 435


>UniRef50_A5FTY4 CBS domain containing protein n=15 Tax=Bacteria RepID=A5FTY4_ACICJ
          Length = 634

 Score = 93.3 bits (230), Expect = 2e-17,   Method: Composition-based stats.
 Identities = 72/388 (18%), Positives = 131/388 (33%), Gaps = 15/388 (3%)

Query: 15  PAVAIGIASSLILIVVMKIASVLQNL-LWQR---LPGTLGIAQDSPLWIIGVLTLTGIAV 70
            A   G+ +  IL+ ++ + + L    +W      PG         LW I V     +A+
Sbjct: 32  CAGLFGVIAGWILLRMIGLINDLAYYGVWSTRMLAPGGAAPGGHPALWTILVPAGGAVAI 91

Query: 71  GLVIRFS----QGHA-GPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMT 125
           GL+ R+     +GH          L GA +         ++  + +  G   G E PI+ 
Sbjct: 92  GLMARYGSEKIRGHGIPEAIEAILLGGARLDLRVAILKPISSAISIGTGGPFGAEGPIIM 151

Query: 126 VNIALAVAIGA-RLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWD 184
              A A  +     L    R    +  +   + A+FGTP          +          
Sbjct: 152 TGGAAASLMAQCFTLTDAERKTLLVAGACAGMTAVFGTP---VAALLLAVELLLFELKPR 208

Query: 185 RLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCL 244
            +     A    A+   L   P    P A    ++    L    +   A     +    +
Sbjct: 209 SIIPVATACITAAILRRLCMTPAPLFPYAGGVIVDPLHALGWLGLGLAAGLGSALLTVLV 268

Query: 245 PRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLL 304
                    +    +   + G ++  +G +  P +L  G  ++ +++A    +      L
Sbjct: 269 YAAEDGFETLPIHWMWWPVLGGLVVGIGGVFDPAALGVGYPDIARLLAGT-LAGGAAIRL 327

Query: 305 AVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLVVT 364
            ++K     VA  SG  GG + P + +G ALG +L   +P           +  ++    
Sbjct: 328 VLVKGVIWSVALGSGTSGGVLAPLLIIGGALGAVLAPVMPHAAPGFWAVLGMAAMMGGTM 387

Query: 365 RDGWLSLFMAAVVV-PNTTLLPLLCIVM 391
           R    S   A  +   +  LLP+L   M
Sbjct: 388 RAPLTSTLFAVELTGNHLILLPVLAASM 415


>UniRef50_C5A3X3 Voltage-gated ClC-type chloride channel n=6 Tax=Thermococcus
           RepID=C5A3X3_THEGJ
          Length = 574

 Score = 93.3 bits (230), Expect = 2e-17,   Method: Composition-based stats.
 Identities = 58/352 (16%), Positives = 112/352 (31%), Gaps = 19/352 (5%)

Query: 59  IIGVLTLTGIAVGLVIRFSQG----HAGPDPACEPLIGAPVPPSALPGLIVALILGLAGG 114
            + +  + G+ V L++                     G  +        IVA  + +  G
Sbjct: 64  YVLLPAIGGLFVALLVVRFPDIKGNGIPEVIEAVIFKGGRIGGVFAIAKIVATSVTIGSG 123

Query: 115 VSLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQT 173
            S+G E PI  +  AL  A      L R  R        A  I   F TP+A A+   + 
Sbjct: 124 GSVGREGPIGFIGAALTSAFAKWFGLSREMRKLLVTCGLAAGIAGTFNTPLAGAMFALEV 183

Query: 174 L-NGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAI 232
           +  G+  +     L    +A+  G   T       F + I       + ++    ++  +
Sbjct: 184 VYMGAFSIN----LVPIFIASVTGNAVTLAVLRRAFEVEIPGGMGHTLPELPFFFVLGLL 239

Query: 233 AIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPV--SLFKGLDEMQQM 290
             A   + V  +        ++  P +   + G +   L     P       G + M  +
Sbjct: 240 LGALAALYVRVIYAFIEGFERLPVPEVFKPVLGGLGVGLLGAFFPNYGIFGVGYEGM-SL 298

Query: 291 VANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAI 350
                        L V+K+ A  +   SG  GG   P++++G   G      V  +  ++
Sbjct: 299 AFYGKLVVWLLLTLGVLKMLATALTIGSGQSGGVFAPSLYIGTMFGSAFGMVVAKLFPSL 358

Query: 351 TVSCA------ILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWL 396
                      +      +T+     + M   +  +  +LP +       +L
Sbjct: 359 GAMPTVYALAGMAAFFSGMTQAPITQILMVTELTRSYAILPAVMTSATMGFL 410


>UniRef50_UPI0001C33F57 chloride channel protein n=2 Tax=Enterobacteriaceae
           RepID=UPI0001C33F57
          Length = 466

 Score = 93.3 bits (230), Expect = 2e-17,   Method: Composition-based stats.
 Identities = 77/411 (18%), Positives = 142/411 (34%), Gaps = 21/411 (5%)

Query: 5   RARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLT 64
           R +T L + L A  +G  + L+ +   +  + + N     + G         +W  G+  
Sbjct: 28  RDKTPLAILLAAAVVGTVAGLLGVAFERAVNSVLNWRIGTIAGYADREWLVWVWAFGLSA 87

Query: 65  LTGIA-VGLVIRFSQGHAGP-DPACEPLIGAPVPPS---ALPGLIVALILGLAGGVSLGP 119
           L  +    LV +F+    G   P  E  +    P      +P   +  +  L  G+ LG 
Sbjct: 88  LLAMVGYFLVRKFAPEAGGSGIPEIEGALEEMRPVRWWRVIPVKFIGGMGTLGAGMVLGR 147

Query: 120 EHPIMTVNIALAVAIGARLLPRVNRMEWTIL--ASAGTIGALFGTPVAAALIFSQTLNGS 177
           E P + +   +   IG     R      T+L   +A  + A F  P+A  L   + +   
Sbjct: 148 EGPTVQLGGNVGRMIGDLFRMRSAEARHTLLATGAAAGLSAAFNAPLAGILFIIEEMRAQ 207

Query: 178 SEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAG 237
               L   + A        ++   +F      + +       +  +    ++  I    G
Sbjct: 208 FRYNLIS-IKAVFTGVIMSSIVFRIFNGEGAVIEVGKLTNAPVNTLWLYLVLGMIFGVVG 266

Query: 238 MVAVWCLPRLHAMMHQMK-----NPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVA 292
            +    + R   M  ++        VLV G+ G   GILG    P ++  G   +   VA
Sbjct: 267 PLFNTLILRAQDMFQRIHGGNTTKWVLVGGLLGGACGILG-FIEPNAVGGGFGLIPIAVA 325

Query: 293 NQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITV 352
              FS      + + ++   V+  +SG  GG   P + +G  LG        +   A  +
Sbjct: 326 GN-FSVGLLLFMFISRVITTVLCFSSGAPGGIFAPMLALGTLLGTAFGMAAASGFPAYHL 384

Query: 353 ------SCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLL 397
                    +  ++    R     + +   +  N  L+  + I  L A LL
Sbjct: 385 EAGTFAVAGMGALLAASLRAPLTGIVLVLEMTDNYQLILPMIITCLGATLL 435


>UniRef50_Q03UF5 Chloride channel protein EriC n=4 Tax=Leuconostoc
           RepID=Q03UF5_LEUMM
          Length = 510

 Score = 92.9 bits (229), Expect = 2e-17,   Method: Composition-based stats.
 Identities = 63/402 (15%), Positives = 139/402 (34%), Gaps = 15/402 (3%)

Query: 8   TMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTG 67
           + L + L    IG  + +++ V       L   +                 +I    +  
Sbjct: 11  SKLSVVLYGTLIGFLTGIVVSVFRWTIEKLLQFVQTLYLDISHGNIALIFLVITANLICF 70

Query: 68  IAVGLVIRFSQGHAGP-DPACEPLIGAPVPP---SALPGLIVALILGLAGGVSLGPEHPI 123
           + V  ++      +G   P  E L+   +     S L    ++ IL +  G+ LG E P 
Sbjct: 71  LIVSWMLNKEPNISGSGIPQVEGLLLGELKINWWSTLWRKFISGILAIGSGLMLGREGPS 130

Query: 124 MTVNIALAVAIGA-RLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPL 182
           + +  ++   + + + L            +A  + + F  P+A  +   + +  S    +
Sbjct: 131 IQLGASIGQGVASYKRLSHNQSKGLIASGAAAGLSSAFNAPLAGVMFVLEEVYHSISPFV 190

Query: 183 WDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVW 242
           W      L  A+     + + F     L I H     +       +   I    G +   
Sbjct: 191 W---VGALTGASVSDFVSTVLFGQTPVLSIGHLSVFPVQLYGLLLVFGIILGLFGFLYQK 247

Query: 243 CLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYF 302
            L        +++ P  + GI  FIL I   I  P  L  G + +  +      +     
Sbjct: 248 FLLFSLNCYSKIRVPKYLYGIVPFILVIPIGILWPNLLGGGNNLILSL-KEAPMTMKMII 306

Query: 303 LLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAIT------VSCAI 356
           ++ +++    +++  SG  GG   P + +G   G ++      +           +   +
Sbjct: 307 VILLVRFVFSMISYGSGLPGGIFLPILTLGALSGALMAHIFVYLHLMSANYALNFIVIGM 366

Query: 357 LGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL 398
            G    + +  + ++ +   +V + T +  L +V L A+L++
Sbjct: 367 AGYFACIGKAPFTAIILIFEMVGSVTHILPLALVSLVAYLVV 408


>UniRef50_C6XZM8 Chloride channel core n=3 Tax=Sphingobacteriaceae
           RepID=C6XZM8_PEDHD
          Length = 594

 Score = 92.9 bits (229), Expect = 2e-17,   Method: Composition-based stats.
 Identities = 68/416 (16%), Positives = 152/416 (36%), Gaps = 42/416 (10%)

Query: 12  LSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVG 71
           L + A+ +GI + L   ++  +   +++ L        G       ++       GI + 
Sbjct: 26  LVIAALIVGILAGLAAALLKSLTHHIEDFL------QTGFHWQYKYYLFFFFPFIGILLS 79

Query: 72  LV-----IRFSQGHAGPDPAC--EPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIM 124
           ++     IR  +   G  P         + + P  +   ++   L +  G S G E PI+
Sbjct: 80  VLYVRRFIRKGKFETGLTPILYTISKKSSKIEPHNIYSQVITAALTVGFGGSTGLEAPIV 139

Query: 125 TVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLW 183
           T    +   +G  L L            +A  I   F +P+A  +   + L     +P  
Sbjct: 140 TSGGGIGSVVGRFLGLSYRETTMLLACGAAAGIAGAFNSPIAGIVFAIEILLPEFTIP-- 197

Query: 184 DRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWC 243
                 L++AA  A+   LF++      +    +M    ++   ++A +     +     
Sbjct: 198 -AFIPLLLSAATAAVVARLFYNEQLFFLVTEGWKMN--ALIYYVLLAVLIGLFSIYFKKV 254

Query: 244 LPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQ--------- 294
              +    ++++NP   + +GG +LGI+ V   P    +G   ++ ++            
Sbjct: 255 NSFIKTSFYKIRNPYKKVVLGGLMLGIM-VFLFPTLYGEGYITIKNLLGGNYTTLLSNSI 313

Query: 295 --AFSTSDYFLLA------VIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPA- 345
              +S+  + ++         K AA ++  ++G  GG   P++ +G  +G  +   +   
Sbjct: 314 FAEYSSLPWVIILFTVVTVFAKSAATLITLSAGGNGGIFAPSLIMGGLIGFAVAFAINTL 373

Query: 346 ----VPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLL 397
               +  A  +   +   +  +       +F+ A +     L+  L I    A+L+
Sbjct: 374 GLAHLSVANFIVAGMAASLSAIMHAPLTGIFLIAEITGGYVLMVPLMITSAIAYLI 429


>UniRef50_Q3AWV3 Possible chloride channel n=12 Tax=Synechococcus RepID=Q3AWV3_SYNS9
          Length = 441

 Score = 92.5 bits (228), Expect = 3e-17,   Method: Composition-based stats.
 Identities = 62/325 (19%), Positives = 114/325 (35%), Gaps = 23/325 (7%)

Query: 30  VMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRFSQG-HAGPDPACE 88
           ++ +  +    LW               W + V    G+ +  + R          P   
Sbjct: 44  IISLIDLATRQLWGGPVEQALGQAPPLAWSVLVCGGFGLLLSFIHRGGSSTLLPELPETM 103

Query: 89  P--LIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARLLPRVNRME 146
                    P       I+   L   GG S+GPE  +      LA  I  R+  + N   
Sbjct: 104 EDLRHPDRAPKRDERRAILGAALAQIGGGSIGPEALMTR----LATLISRRM-WKGNDQA 158

Query: 147 WTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHP 206
               + AG++G   G P+   ++      G  +  +  R    ++   +G +        
Sbjct: 159 LQSASVAGSLG-FLGAPLLGGMVV-----GERKQDVLRRWIPGILGGLSGFVAFHGINEA 212

Query: 207 HFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVL----- 261
                + +   +  ++I         A+ AG V            + ++   L+      
Sbjct: 213 SGG-SLKNLPYVWPSNIGESFDTLVAALLAGAVGCGLGLIFQRWRYWLEQRRLMARWCWW 271

Query: 262 -GIGGFILGILGVIGGPVSLFKGLDEMQQMVANQ-AFSTSDYFLLAVIKLAALVVAAASG 319
             + G +LG L +   P+  F G ++M+ ++ NQ +  ++  FL A  KL  L +   +G
Sbjct: 272 PVVTGVLLGAL-MHWLPLVPFGGEEQMRPLLENQQSHPSALLFLSAFGKLLMLGLCLETG 330

Query: 320 FRGGRIFPAVFVGVALGLMLHEHVP 344
           +RGG  FP   +  A G  LH+  P
Sbjct: 331 WRGGIFFPVFLIACATGTGLHQIFP 355


>UniRef50_B2VDE2 Cl-channel, voltage gated n=4 Tax=Enterobacteriaceae
           RepID=B2VDE2_ERWT9
          Length = 563

 Score = 92.5 bits (228), Expect = 3e-17,   Method: Composition-based stats.
 Identities = 72/397 (18%), Positives = 161/397 (40%), Gaps = 22/397 (5%)

Query: 14  LPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLT-LTGIAVGL 72
           L A+ +G+ +SL+ +   +    +  LL+          +  P +   ++    G+  G 
Sbjct: 15  LVAIPVGLVASLVTLAFREAIVWIDGLLFNGQTDITQAMRIYPWYCWPLIVGCGGLIAGY 74

Query: 73  VIRFS------QGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTV 126
            +R++      Q                VP        ++ +  ++ G S+G E P++ +
Sbjct: 75  FLRYATAIEQKQASRSDYLEVINARLDAVPTRTSLFRGLSSLASISSGASIGREGPMVQL 134

Query: 127 NIALAVAIGARLLP--RVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWD 184
           +      +G  L     +   +   +A+A  + +++  P+A+A+  ++    +  +    
Sbjct: 135 SALSGSLMGRWLFKNLALKNSDVVAMAAAAGLSSVYHAPLASAIFVAEI---AFGISAMQ 191

Query: 185 RLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTD--ILSGAIVAAIAIAAGMVAVW 242
           RL   ++++    LT     +     P +H GQ E+    I     +  +A   G V + 
Sbjct: 192 RLIPLIISSGTAVLTMWSLGYHSAIYPFSH-GQFELAPESITLTIAIGLLAGLLGWVMIA 250

Query: 243 CLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYF 302
            +     +   +++  L LG+GG ++G L  IG    L  G + + +++A   F      
Sbjct: 251 MINHSKRLFAPLRSLPLRLGLGGLLVGGLA-IGSSQILGNGYEVIVRIMAG-DFLLPMLL 308

Query: 303 LLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEH-----VPAVPAAITVSCAIL 357
            L ++K+ A  ++  S   GG   PA+ +G  +G M+         P    A+  +  + 
Sbjct: 309 ALLLLKMLATAISVGSSAVGGLFTPALLIGALMGSMMALLAVKAGFPPGNVAVFAAIGMG 368

Query: 358 GIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPA 394
            ++  V++   +++ M   +  N++LL    I  + A
Sbjct: 369 ALLASVSQAPLMAMLMVLEMTLNSSLLFPAMIASVLA 405


>UniRef50_Q040F7 Chloride channel protein EriC n=29 Tax=Lactobacillus
           RepID=Q040F7_LACGA
          Length = 534

 Score = 92.5 bits (228), Expect = 3e-17,   Method: Composition-based stats.
 Identities = 77/427 (18%), Positives = 154/427 (36%), Gaps = 23/427 (5%)

Query: 6   ARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTL 65
            ++ L L L A+ +G+ + +++          +   W  L           + I+  L L
Sbjct: 22  EKSNLKLMLQALCVGLIAGVVVGFFRYGIGKTEAF-WLDLFKKSHQNPLWFIVIVAGLAL 80

Query: 66  TGIAVGLVIRFSQGHAGP-DPACEPLIGAPVPPSALPGL---IVALILGLAGGVSLGPEH 121
           TGI  G  ++      G   P  +  +   +     P L   ++  I+ +  G+ LGPE 
Sbjct: 81  TGIIAGYFVKQYPHVGGSGIPEVKLQMQGKLTLQWWPILWRKLIGGIMVIGTGLFLGPEG 140

Query: 122 PIMTVNIALAVAIGARLLP-RVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEV 180
           P + +   +   +G      + N        +A  + A FG P++ AL   + +  +   
Sbjct: 141 PSLQLGSTIGQGVGQGFKQTKTNSRVLLATGAASGLSAAFGAPLSGALFVLEEIFHNFSP 200

Query: 181 PLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVA 240
            +W      L+ A A        F    +L +A+     M       ++  I    G + 
Sbjct: 201 RVW---MNALVGAIASNFVVSNLFGQKPALALAYNHSFPMPLYWHLVLLGLILGLLGHLY 257

Query: 241 VWCLPRLHAMMHQMK-NPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFS-- 297
              L  L     ++   P  + G+   ++ +  +   P+    G   +  +  + A+S  
Sbjct: 258 KLGLFNLKKFYAKITFIPRWLHGLIPLVILMPIMYYLPLITGPGNHLILSLPKSIAYSSW 317

Query: 298 --TSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEH------VPAVPAA 349
                  +  VI++A  +V+  SG   G   P + +G  +G            +P     
Sbjct: 318 NLVGMLAIFYVIRIAFSIVSYDSGLPSGIFLPILTMGALIGATYGLFMVQLGLLPQKLVI 377

Query: 350 ITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWL---LLAGKPMMMV 406
             +  A+ G    + R  + ++ +   +V +   L  L +V   A L   LL G+P+   
Sbjct: 378 NLIIFAMAGYFAAIIRAPFTAIILITEMVGSLLHLMPLAVVAFIALLVDQLLGGRPIYDS 437

Query: 407 NRPKQQP 413
                +P
Sbjct: 438 LAAAMEP 444


>UniRef50_B5ZIM0 Chloride channel core n=11 Tax=Acetobacteraceae RepID=B5ZIM0_GLUDA
          Length = 628

 Score = 92.1 bits (227), Expect = 3e-17,   Method: Composition-based stats.
 Identities = 68/328 (20%), Positives = 123/328 (37%), Gaps = 9/328 (2%)

Query: 73  VIRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAV 132
           + R++ G          L G  +       + +  +L  + G S+G E     +  A   
Sbjct: 129 IARYAPGRPVDPIEANALHGGRMSTLDSAIVALQTVLSNSVGASVGLEAGFTQIGAATGS 188

Query: 133 AIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLM 191
            +G    + R +        +AG IGA F  P+A A    + + G           AP+ 
Sbjct: 189 RLGRMFRVRREDLRLLVGCGAAGAIGAAFNAPLAGAFYAFELVIG----TYSLANLAPVA 244

Query: 192 AAAAGAL-TTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAM 250
           AA+  A+  T L       + +     + M D L  A +  +A   G+  ++C+     +
Sbjct: 245 AASICAIGVTHLLHSAAPGVTVDLPAGLRMDDYLPIATLGIVAALLGVALMYCVTLAETL 304

Query: 251 MHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLA 310
             +   P  +    G  +     +  P  L  G   M+  +     +     LLA+ K  
Sbjct: 305 FRRSGLPAWMCPAVGGTIVGTMALVSPSVLSSGHWAMRVALEQGHPTGWILVLLAL-KAV 363

Query: 311 ALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAV--PAAITVSCAILGIVLVVTRDGW 368
           A  V+  SGFRGG  F ++++GV  G      +  V         CA++G+  +      
Sbjct: 364 ASSVSIGSGFRGGLFFASLYLGVLTGAAFGGGLALVSANPLSAELCALVGMSAMAVAVVG 423

Query: 369 LSLFMAAVVVPNTTLLPLLCIVMLPAWL 396
             + M  + +  T  LPL   V++ + +
Sbjct: 424 GPMTMVFLALEMTGSLPLTVAVLVASVI 451


>UniRef50_A9CJ03 Chloride channel protein n=2 Tax=Rhizobium/Agrobacterium group
           RepID=A9CJ03_AGRT5
          Length = 593

 Score = 92.1 bits (227), Expect = 3e-17,   Method: Composition-based stats.
 Identities = 81/403 (20%), Positives = 157/403 (38%), Gaps = 18/403 (4%)

Query: 7   RTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLT 66
           R  L L   AV IG+A+ L++ ++  +++ L  L++      L  +  S   ++    + 
Sbjct: 29  RGELGLVALAVLIGVAAGLLVALIGALSTALHILVFGV--ERLSSSDLSGRIVLFGPIIG 86

Query: 67  GIAVGLVIR---FSQGHAGPDP-ACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHP 122
           G+ +GL+I     ++     DP     L G  +  +    + V  I+    G S+G E  
Sbjct: 87  GMLLGLIIFILSKTRKKPMIDPIEANALHGGRLSLTDSIIVCVQNIVSNGFGASVGLEAG 146

Query: 123 IMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVP 181
              +   +A  IG +L L R +        +AG I A F  P+  A    + + G+  V 
Sbjct: 147 YTQIASGVASKIGIKLKLRRGDMRILVGCGAAGAIAAAFNAPLTGAFYAIELIIGTYTV- 205

Query: 182 LWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAV 241
               L   +++A       GL      S+ I    ++   D +    +  +  A G+V +
Sbjct: 206 --VTLAPLIVSALVATTVIGLIGGHGLSIDIVDASRVTPADYVPAIFLGVVCAAIGIVLM 263

Query: 242 WCLPRLHAMMHQMKNP-VLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSD 300
             +  +     +   P  L   +GG  +G L +I  P  L  G   +  +  +   +   
Sbjct: 264 QAVSFIEETARKSAIPGWLRPTLGGVAVGGLALIS-PQVLSSGHGALH-LNIDAELTIYG 321

Query: 301 YFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVP-----AVPAAITVSCA 355
              L ++K AA  ++  S FRGG  F ++F+G  LG +     P     +    +     
Sbjct: 322 LAGLFMLKAAASAISIGSNFRGGLFFASLFMGSLLGKIFALCAPYIGYGSTAPIVYAVIG 381

Query: 356 ILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL 398
           +      +        F+A  +  +  +  L+   ++   L++
Sbjct: 382 MSAFAAAIIGGPLTMTFLALELTGDFQITALVLAAVITTSLVV 424


>UniRef50_C6HUP8 Putative Cl-channel, voltage gated n=1 Tax=Leptospirillum
           ferrodiazotrophum RepID=C6HUP8_9BACT
          Length = 572

 Score = 92.1 bits (227), Expect = 4e-17,   Method: Composition-based stats.
 Identities = 63/413 (15%), Positives = 141/413 (34%), Gaps = 26/413 (6%)

Query: 16  AVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVG---L 72
           +V IG+ +  ++ +   I  V+  LL+  L      A  + L ++ ++ + G+ V    L
Sbjct: 31  SVLIGVTTGFLVYL---IERVVYRLLFLTL---YNTAFKNHL-VVILIPMAGVLVARYIL 83

Query: 73  VIRFSQGHAGPDPACEPLIG--APVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIAL 130
                    G +   +        +P       I A I  L  G S G E     +   +
Sbjct: 84  ASGRVDNAGGTEEIIKSYHEYRGKLPLRNALFKIPAYISTLGFGGSAGLEGASTYIGGVV 143

Query: 131 AVAIGARL----LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRL 186
           +  +        +P   +    +  +A  + A+F  P   A+   Q    S   P  + L
Sbjct: 144 SSLVDRTFSWLRIPYEEQRVMLLAGAAAGLSAMFKAPFTGAIFVLQVPYRSDIAP--NAL 201

Query: 187 FAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPR 246
              L+++ +  +             +A   Q    D LS  ++  +      + +    +
Sbjct: 202 VPTLISSVSSYIVMVSLVGTAPLFQLAAKAQFHFKDFLSVIVIGVVCGFLTALFIRIYRQ 261

Query: 247 LHAMMHQM-KNPVLVLGIGGFILGILGVI------GGPVSLFKGLDEMQQMVANQAFSTS 299
                 +  ++ + +  I G ++  L         G  + L  G   +Q ++        
Sbjct: 262 TKRWFSEGSRHRIGLRPILGALILGLTGYVATRAWGEALPLGPGYIFIQHLLTGN-VPID 320

Query: 300 DYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGI 359
               L  +K  A++   ++G  GG  FP + +G A G ++ +     P    V   +   
Sbjct: 321 MALELFFLKAIAVIFTFSAGGIGGSFFPLLSLGAATGSVVAQIAGLEPYDFGVVMGMSAF 380

Query: 360 VLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNRPKQQ 412
           +    +    ++   A    ++  L    I  + ++++     +    R ++ 
Sbjct: 381 LAAGYKTPLAAVVFIAEATHSSGYLIPGLIGTVVSYVVSGSTSISTHQRDRED 433


>UniRef50_A0LKT1 Cl-channel, voltage-gated family protein n=1 Tax=Syntrophobacter
           fumaroxidans MPOB RepID=A0LKT1_SYNFM
          Length = 612

 Score = 92.1 bits (227), Expect = 4e-17,   Method: Composition-based stats.
 Identities = 83/411 (20%), Positives = 141/411 (34%), Gaps = 33/411 (8%)

Query: 15  PAVAIGIASSLILIVVMKIASVLQNLLWQRLPGT----------LGIAQDSPL--WIIGV 62
            +VAIGI S L+   V  +         + L G           + +  D+PL  W++ +
Sbjct: 43  YSVAIGILSGLMACAVFALLEWTSFFCLEYLAGYAVAKPAGEHLVDLVADTPLRRWVLFL 102

Query: 63  LT-LTGIAVGLVI-RFSQGHAGP------DPACEPLIGAPVPPSALPGLIVALILGLAGG 114
           L    G+  GL++  ++    G       D               + G  +A ++ L+ G
Sbjct: 103 LPAFGGLLSGLIVYTWAPEAEGHGMDAFIDAFHNKSGHIRTRVPFVKG--IASVITLSTG 160

Query: 115 VSLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQT 173
            S G E PI  +   +   +G    L    R    +   A  +GA+F  P+  AL   + 
Sbjct: 161 GSAGREGPIAQIGAGIGSCLGRAFHLTARERRLMLLAGCAAGLGAIFRAPLGGALTAIEV 220

Query: 174 LNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIA 233
           L           L            T      P F      +      ++L   I+A I 
Sbjct: 221 LYREDFEAEGIVLCIISSVTGYAIFTAIFGHEPIFETTALPFS--NPVELLFYGILALIC 278

Query: 234 IAAGMVAVWCLPRLHA-MMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVA 292
           +  G   V     L   +  ++    + +   G +L  L  +  P  L  G   +QQ + 
Sbjct: 279 VPFGYAYVKIFYGLRDHLFRRLPLKRVFVPALGGLLVGLLGLFAPQVLSGGYGTIQQALK 338

Query: 293 NQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITV 352
            +  S     LLA +K+ A     +SG  GG   P++F+G  LG  + +        +  
Sbjct: 339 GE-VSAGLLLLLAALKIVATSFTISSGGSGGVFGPSLFIGAMLGGAVGQLSHEWFPTLVT 397

Query: 353 SCAILGIV------LVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLL 397
                 +V        V +    +L M   +     L+  L    + A LL
Sbjct: 398 QPGGFALVGMGAFFAGVAKAPIGALLMVCEMTGGYGLVVPLMFTSVVAILL 448


>UniRef50_B8H095 Chloride channel protein n=15 Tax=Proteobacteria RepID=B8H095_CAUCN
          Length = 618

 Score = 91.8 bits (226), Expect = 4e-17,   Method: Composition-based stats.
 Identities = 62/308 (20%), Positives = 107/308 (34%), Gaps = 9/308 (2%)

Query: 58  WIIGVLTLTGIAVGL----VIRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAG 113
           W +  + L G+ +GL    V+RF   HA        L G  +       + V  ++    
Sbjct: 106 WRLLAIPLGGLVLGLFTAAVLRFRPNHAVDPVEANALHGGRLSIRDSLIICVQTLISNGS 165

Query: 114 GVSLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQ 172
           G S+G E        A A  +G RL L R +        +   I A FG P+  A    +
Sbjct: 166 GASVGLEAAYAQAGGATASWVGQRLNLRRGDLRILVGAGAGAAIAAAFGAPLTGAFYAFE 225

Query: 173 TLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAI 232
            + G+  V     + A  +A               + L  +        D     ++  +
Sbjct: 226 IVIGAYTVANIAPVAAAALAGVL---VAKALGSTPYLLKTSVVAISSPADYALYGLLGLL 282

Query: 233 AIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVA 292
           A   G+  +  +        +   P       G +      +  P +L  G   +  +  
Sbjct: 283 AAFFGVALMRAVAVADGWAIKAPLPRWSKPAIGGVALAALALATPQTLSGGHGALH-LDL 341

Query: 293 NQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITV 352
           N         +L ++K  A +V+ +SGFRGG  F A+F+GV +G      V      + +
Sbjct: 342 NSDLPLKVLLVLILMKAVASIVSLSSGFRGGLFFAALFLGVLMGQAFALVVNMTTGTVHL 401

Query: 353 SCAILGIV 360
                 +V
Sbjct: 402 DPIAASLV 409


>UniRef50_C0M694 Voltage gated chloride channel protein n=5 Tax=Firmicutes
           RepID=C0M694_STRE4
          Length = 408

 Score = 91.8 bits (226), Expect = 4e-17,   Method: Composition-based stats.
 Identities = 65/349 (18%), Positives = 133/349 (38%), Gaps = 13/349 (3%)

Query: 50  GIAQDSPLWIIGVLTLTGIAVGLVI----RFSQGHAGPDPACEPLIGAPVPPSALPGLIV 105
            +     ++++  L L G+ +  +     + ++   G            +P   +P +I+
Sbjct: 45  AVRDAHLIYLLPCLALAGLVIVFLYEQYGQIAKQGMGLVFDVGHGEKTRLPLVLIPLIIL 104

Query: 106 ALILGLAGGVSLGPEHPIMTVNIALAVAIGARLLPRVNRMEWTILASAGTIGALFGTPVA 165
           +  L    G S G E   + +   ++   G     +     + ++  A     LF TP+ 
Sbjct: 105 STWLTHLCGGSAGREGVAVQIGATVSHFFGRLRHLKDKSQLFLVMGMAAGFAGLFQTPMT 164

Query: 166 AALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILS 225
           A +   + L   +    +  L   L+AA   + T+       FS+PIA   ++       
Sbjct: 165 AVVFALEVLLLGNIS--YLALLPSLIAAFTASWTSHCLGLEKFSVPIAKALKITPITFGK 222

Query: 226 GAIVAAIAIAAGMVAVWCLPRLHA-MMHQMKNPVL-VLGIGGFILGILGVIGGPVSLFKG 283
             ++  I   AG +    L R    +  ++ NP   VL +GGF+   L +         G
Sbjct: 223 LVLLGLIFGLAGNLFASLLARAKPYIAARLPNPYYRVLLVGGFLSLSLLLCHYGRYSGLG 282

Query: 284 LDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHV 343
            + +    ++Q  +  D+ L    KL   ++  ++GF+GG + P   +G ALG++L   +
Sbjct: 283 TNLITAAFSHQPIANYDWLL----KLLFTIITLSAGFQGGEVTPLFAIGAALGIVLAPWL 338

Query: 344 PAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVML 392
             +PA +  +     +    T      +F+   V   T       ++  
Sbjct: 339 -GLPAQLAAALGYAAVFGSATNTFLAPIFVGLEVFGATNATAYFIVIAF 386


>UniRef50_Q2JA24 Cl-channel, voltage gated n=4 Tax=Actinomycetales
           RepID=Q2JA24_FRASC
          Length = 626

 Score = 91.8 bits (226), Expect = 5e-17,   Method: Composition-based stats.
 Identities = 69/385 (17%), Positives = 136/385 (35%), Gaps = 28/385 (7%)

Query: 19  IGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSP-------LWIIGVLTLTGIAVG 71
           IG    L  +    + ++   +   R   ++G    +P        +++ V  + G+  G
Sbjct: 34  IGAGVGLGAVAFRGLINLFTEVFCGRADCSVGGRLPNPHIPDLGFWFLLAVPVIGGLVYG 93

Query: 72  LVIRF----SQGHA-GPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTV 126
            +I      ++GH      +        + P       +A  L +  G S+G E PI+ +
Sbjct: 94  PLIHRFAREARGHGVPEVMSAVAERDGRISPRVSAVKSLASALCIGAGGSVGREGPIVQI 153

Query: 127 NIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDR 185
             +L  A+G  L +P           +AG I A F  PVA  L   + +  +     +  
Sbjct: 154 GASLGSALGQLLRVPGRRLPILVACGAAGGIAATFNAPVAGVLFALEVILRTFTAEAFGV 213

Query: 186 LFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLP 245
           +   ++AA   ++     F     L +  +      +     ++  +A   G++    L 
Sbjct: 214 V---VLAAVTASVIGRAAFGDTPFLSLPTFALHSQGEYPLFILLGVVAGLTGVLFTRLLY 270

Query: 246 RLHAMM-HQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLL 304
            +  +     + P  +    G +L    ++  P     G   ++  V       + +FLL
Sbjct: 271 LIEDLCDWAWRGPEWLRPAVGGLLLGTVLLALPQMYGVGYPVLEHTVHGG---YALWFLL 327

Query: 305 AVI--KLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLV 362
            +I  K+ A  +    G  GG   P++F+G + G         +            +V  
Sbjct: 328 VLIGGKIVATSLTIGIGGSGGVFAPSLFIGASTGAAFGTLAHHIAPGTIAPVGAYALV-- 385

Query: 363 VTRDGWLSLFMAAVVVPNTTLLPLL 387
               G  ++F  A   P T +L L 
Sbjct: 386 ----GMGAVFAGAARAPITAVLILF 406


>UniRef50_Q1LQV6 Cl-channel, voltage gated n=66 Tax=Proteobacteria
           RepID=Q1LQV6_RALME
          Length = 637

 Score = 91.4 bits (225), Expect = 5e-17,   Method: Composition-based stats.
 Identities = 77/374 (20%), Positives = 139/374 (37%), Gaps = 16/374 (4%)

Query: 11  LLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPL---WIIGVLTLTG 67
           +L+  A+ IG  S+    V++ +     NL + +       +        W+I V  + G
Sbjct: 61  MLAAIALGIGAISTGAAYVLVNLIHFFTNLFFFQTLSFADRSPAGHTLGPWVIVVPAIGG 120

Query: 68  IAVGLVIRFSQG-----HAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHP 122
           + VGL+ R+                     + + P       ++  + +  G   G E P
Sbjct: 121 LIVGLMARYGSDKIRGHGIPEAIEAVLFGKSKMSPKVAVLKPLSSGIVIGSGGPFGAEGP 180

Query: 123 IMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVP 181
           I+    ++A  +   L L    R    +  +   + A+FGTPVAA L+  + L    E+ 
Sbjct: 181 IIMTGGSIASLLAQYLHLTAAERKTLLVSGACAGMTAIFGTPVAAVLLAIELL--LFELR 238

Query: 182 LWDRLFAPLMAAAAGALTTGLF-FHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVA 240
               L   L  A AG L   +F   P F L            + S  +   +  A G   
Sbjct: 239 PRSLLPVALACAVAGFLRPFVFEAGPLFPLQT---APASTLALGSCVLAGLLCGALGAGL 295

Query: 241 VWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSD 300
              L R       ++   +     G ++  +G    P +L  G D +  ++ N+    + 
Sbjct: 296 TLALYRTEDAFDHLRLHWMWWPAIGGLVVGIGGYFEPRALGVGYDVIGDLLNNRLLVEAA 355

Query: 301 YFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIV 360
             LLAV  +  +  A  SG  GG + P + +G  LG++L   +P     +     + G++
Sbjct: 356 VALLAVKAVIWIA-ALGSGTSGGVLAPLLMLGAGLGVVLAPMLPGGSPGLWALVCMAGVL 414

Query: 361 LVVTRDGWLSLFMA 374
             V      ++  A
Sbjct: 415 GSVLGAPLTAIVFA 428


>UniRef50_C6X6C8 Chloride channel protein n=2 Tax=Flavobacteriaceae
           RepID=C6X6C8_FLAB3
          Length = 454

 Score = 91.4 bits (225), Expect = 5e-17,   Method: Composition-based stats.
 Identities = 50/316 (15%), Positives = 119/316 (37%), Gaps = 13/316 (4%)

Query: 95  VPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARLL---PRVNRMEWTILA 151
           +    +   I++ ++ + GG ++G E P + +  ++   +   L    P++++    +  
Sbjct: 119 LSVKIIVLKILSSLILVIGGGAVGREGPTIQIAGSVFRKVNEYLPDWWPKISKKNMIMTG 178

Query: 152 SAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLP 211
           +A  + A F TP+   +   + L+ +        LF  ++ A    LT       +  L 
Sbjct: 179 AAAGLSAAFNTPLGGIVFAVEELSKTHINYFKTALFTAVIIAG---LTAQTLAGSYLYLG 235

Query: 212 IAHYGQMEMTDILSGAIVAAIAIAAG---MVAVWCLPRLHAMMHQMKNPVLVLGIGGFIL 268
                 + +T +    +VA I+        V +  +      +   K  ++ L I   I+
Sbjct: 236 YPKTSGVALTIMFPVILVAGISGICASQLSVFMIKITAWKKNLKTQKAHIIFLVISALII 295

Query: 269 GILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPA 328
             L        L  G + M++ +         Y  L   ++    ++  SG  GG   PA
Sbjct: 296 ASLAYFVNREILGSGKEIMERTLFTDDKHEDWYMPL--FRMIGPALSFTSGGAGGIFAPA 353

Query: 329 VFVGVALGLMLHEHVPAVP--AAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPL 386
           +  G ++G ++   +   P    + +   ++  +  +TR  + S  +   +    +L+  
Sbjct: 354 LSAGASIGSVISGWINLTPNETNVVILAGMVAFLTGITRAPFTSAIIVLEMTDRHSLIFH 413

Query: 387 LCIVMLPAWLLLAGKP 402
           L +  + + L+     
Sbjct: 414 LMLAGMVSSLISLIIS 429


>UniRef50_Q72EW7 Chloride channel family protein n=6 Tax=Desulfovibrionales
           RepID=Q72EW7_DESVH
          Length = 603

 Score = 91.4 bits (225), Expect = 5e-17,   Method: Composition-based stats.
 Identities = 71/405 (17%), Positives = 125/405 (30%), Gaps = 24/405 (5%)

Query: 25  LILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVG-LVIRFSQGHA-- 81
           L+    + + +     L+             P  I      TG+  G LV RF       
Sbjct: 54  LVAWAGLSLPAPAGEGLFH---DAAAGGAYRPWVIPLATCATGLVTGWLVQRFLPDSLAG 110

Query: 82  ---GPDPACEPLIGAPVPPSALPGLI--VALILGLAGGVSLGPEHPIMTVNIALAVAIGA 136
              G D                   I  +  IL +A G S G E PI  +   L   +  
Sbjct: 111 MTDGTDAMIRAFHRGKGVIRKRAPFIKGLTSILTIASGGSAGREGPISQIGAGLGSFVAD 170

Query: 137 RL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAA 195
           RL L    R    +  +AG +GA+F  P+  AL   + +         + +   ++++  
Sbjct: 171 RLHLSTKERRLLMLAGAAGGLGAVFRAPLGGALTAIEVVYREDFEA--EAMLPAILSSVV 228

Query: 196 GALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLH-AMMHQM 254
                   F       I  +   +M ++     +A      G   V     +   +  ++
Sbjct: 229 AYTLFAYVFGTEPMFAIPRFSFSDMRELPFYLTLALACAFTGWAYVRTFRFMKYGVFLRL 288

Query: 255 KNPVLVLGIGGFILGILGVIGGPVS--LFKGLDEMQQMVANQAFSTSDYFLLAVIKLAAL 312
              V ++        ++G+ G   +  L  G   ++Q +     + +    + V K  A 
Sbjct: 289 AERVGIMWTTALGGLLVGLFGIIYTPMLSDGYGWVEQAILG-HLTVTTMVTIMVAKTLAT 347

Query: 313 VVAAASGFRGGRIFPAVF----VGVALGLMLHEHVPAV--PAAITVSCAILGIVLVVTRD 366
            +   SG  GG   PA+F     G  +G   H+  P +       V   +      V   
Sbjct: 348 AMTLGSGMSGGMFAPALFVGGMTGGVVGYAAHDLFPHIVREPGGYVLVGMAAFFAGVAHA 407

Query: 367 GWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNRPKQ 411
               L M   +     LL  L +      LL     +       +
Sbjct: 408 PVGPLIMVCELTQGYGLLAPLMLASAVCILLNRKVSLYENQVENK 452


>UniRef50_C5PV52 Chloride channel protein n=1 Tax=Sphingobacterium spiritivorum ATCC
           33861 RepID=C5PV52_9SPHI
          Length = 596

 Score = 91.4 bits (225), Expect = 6e-17,   Method: Composition-based stats.
 Identities = 69/418 (16%), Positives = 140/418 (33%), Gaps = 38/418 (9%)

Query: 12  LSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVG 71
           L + A  +GI   +       +   + + +   L   +        +++  L    ++V 
Sbjct: 26  LIILAFVVGIIGGIAA----SVLKGMTHFIASALQDDVEWHYKYSFYLVFPLIGILLSVL 81

Query: 72  LVIRFSQG---HAGPDPAC--EPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTV 126
            + +F +G     G  P         + + P  +   I+   + +  G S G E PI   
Sbjct: 82  YIRKFLKGKNFEHGITPIIYSISRKSSRIEPHNVYSQIITSAVTVGFGGSSGLEAPIAYS 141

Query: 127 NIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDR 185
             A+   +G    L            +A  I   F +PVA  +   + L     +P +  
Sbjct: 142 GSAIGSNVGRFFGLQYREITMLLACGAAAGISGAFNSPVAGMIFAIEILLPEFSIPAFIP 201

Query: 186 LFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLP 245
           L   + +A A  ++  L+  P F    + +   E   +    I++ +     +       
Sbjct: 202 LL--ISSALASVISRLLYSEPLFHTATSDW---EFKALFFYVIMSVLVGLYTVYFAKISA 256

Query: 246 RLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTS------ 299
            + +   ++KNP   +   G  LG++ +   P    +G   +QQ++  +  S        
Sbjct: 257 IIKSWFSKIKNPYNKVWFSGISLGVM-IFIFPALYGEGYLTIQQLLDGRFDSIVKNSLFS 315

Query: 300 -----------DYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLH-----EHV 343
                         L    K  A +     G  GG   P++ +G  LG           +
Sbjct: 316 SYKDIGWVVVAYTVLTLFGKSFAALFTLNGGGNGGVFGPSLVMGGLLGFAFAYGMNLTGL 375

Query: 344 PAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGK 401
             +     V   +   +  +      S+F+ A +    TL+  L +V   A+L+    
Sbjct: 376 VTLNIPNFVMAGMAAALAGIMHAPLTSIFLIAEITGGYTLMVPLMLVASIAYLINRAI 433


>UniRef50_Q0ABK0 Cl-channel, voltage-gated family protein n=1 Tax=Alkalilimnicola
           ehrlichii MLHE-1 RepID=Q0ABK0_ALHEH
          Length = 575

 Score = 91.4 bits (225), Expect = 6e-17,   Method: Composition-based stats.
 Identities = 69/391 (17%), Positives = 140/391 (35%), Gaps = 29/391 (7%)

Query: 11  LLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAV 70
           L++L AV  G+A+  +++    +    Q  L    P           W + +  + G  +
Sbjct: 23  LMALLAVLCGLATGGVILGFRWVVESSQTGLLGG-PEQFWALPAH--WRVLLPVIGGALI 79

Query: 71  GLVIRFSQGHAGPDPACEPLIGAPVPP-------SALPGLIVALILGLAGGVSLGPEHPI 123
           GL++++ +            +   +                V     L  G S+G E P 
Sbjct: 80  GLMLQWLR--PEHRGTGVVHVMERLGYHQGYMSWRNAAAQFVGASTALISGHSVGREGPA 137

Query: 124 MTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPL 182
           + +  A    +G RL LP  +         AG IGA F TP+A  +   + +     +  
Sbjct: 138 IHLGAASGSLLGQRLGLPNNSLRTLVACGVAGAIGATFNTPLAGVIFAMEVVMLEYTL-- 195

Query: 183 WDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVW 242
                  +++A    + T L +      P      + +  +     +    +  G +A  
Sbjct: 196 -SGFLPVMLSAVTATVVTQLVYGNT---PAFSVPAVHLESLGELGWLLVCGLLIGTLAAA 251

Query: 243 CLPRLHAMMHQMKNPVL--VLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSD 300
            +  L    + +    L     + G  +G++G +  P  +  G + +  ++  +  + + 
Sbjct: 252 FIQSLMFFSNSLTRWPLAARTTLAGLAVGLIG-LALPEVMGVGYETVNLILLGEVATITL 310

Query: 301 YFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAV------PAAITVSC 354
             L+A  KL A  +A   G  GG I P V +G A G +L +   A+        ++ V  
Sbjct: 311 VALVA-AKLLASTLAVGLGIPGGLIGPTVVIGAAAGGLLGQAAQALFPEMASEPSLYVML 369

Query: 355 AILGIVLVVTRDGWLSLFMAAVVVPNTTLLP 385
            +  ++    R    +L     +  N  ++ 
Sbjct: 370 GLGAMMGATLRAPLAALTAMLELTANPNIIL 400


>UniRef50_C6P622 Chloride channel core n=1 Tax=Sideroxydans lithotrophicus ES-1
           RepID=C6P622_9PROT
          Length = 428

 Score = 91.0 bits (224), Expect = 7e-17,   Method: Composition-based stats.
 Identities = 63/305 (20%), Positives = 120/305 (39%), Gaps = 8/305 (2%)

Query: 95  VPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGA--RLLPRVNRMEWTILAS 152
           +      G I+  ILGL  G S+G E P + +  ++   +G+  R           +  +
Sbjct: 103 LSLRVTMGKIMLTILGLMSGTSVGREGPTVQIGASIMHKLGSLARFPKHDLDKGLILAGA 162

Query: 153 AGTIGALFGTPVAAALIFSQTLNGSSEV-PLWDRLFAPLMAAAAGALTTGLFFHPHFSLP 211
           A  + A F TP+A  +   + ++ S E       L   ++A        G + +   +  
Sbjct: 163 AAGVAAAFNTPLAGIVFAIEEMSRSFEEHNSSTILMTVIIAGIVSLALLGNYSYFGHTSE 222

Query: 212 IAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMM--HQMKNPVLVLGIGGFILG 269
              +G+     I+ G +   +  A     +     L   M      NPV    + G +L 
Sbjct: 223 SMDFGKEWYVVIVCGIVGGTLGGAFSRALIEVNKGLAGSMGTWIRANPVRFAAVCGLLLA 282

Query: 270 ILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAV 329
           ++G+  G  +   G +E + ++   A    +Y    ++K+AA V++  SG  GG + P +
Sbjct: 283 LIGLASGNNTYGSGYNEAKSLLVGNAALPDNY---GLLKMAATVISYISGIPGGIMAPTL 339

Query: 330 FVGVALGLMLHEHVPAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCI 389
             G   G  +   V +VP A TV   ++     VT+    +  +   ++ N  ++  L  
Sbjct: 340 SAGAGFGANIASFVTSVPVAATVILGMVAYFAGVTQAPITAFVIVMEMIDNHEMVLPLMA 399

Query: 390 VMLPA 394
               A
Sbjct: 400 TAFIA 404


>UniRef50_Q8XTT4 Putative chloride channel protein clcB-like n=62
           Tax=Burkholderiaceae RepID=CLCL_RALSO
          Length = 429

 Score = 91.0 bits (224), Expect = 7e-17,   Method: Composition-based stats.
 Identities = 73/399 (18%), Positives = 142/399 (35%), Gaps = 23/399 (5%)

Query: 16  AVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWI-IGVLTLTGIAVGLVI 74
           A  IG A +L  I   +    LQ  L     G +  A+  P W  + V T  G+  GL +
Sbjct: 5   AGLIGCAGALATIAFRECLRQLQWWLAGADQGLVATARALPWWARLLVPTAGGLLAGLTL 64

Query: 75  RFSQGHAG-----PDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIA 129
           ++                  +    +          + +  +A G S+G E P++ +   
Sbjct: 65  QYGLKWIPRKGAEDYMEAIAVGDGVLSARQSLVRSASSLCSVASGASIGREGPMVQLAAM 124

Query: 130 LAVAIGARLLPR-----VNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWD 184
               +G  L         +        +A  I + +  P+A A+   + + G+       
Sbjct: 125 CGSLLGRVLRHAMPVSVEHMRLLVACGAAAGITSAYNAPIAGAVFVCEIVFGAITTA--- 181

Query: 185 RLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCL 244
            L   L++A    +    FF       + H+  +   ++L+   +   A  AG + +  +
Sbjct: 182 TLGPLLVSAVTADIIVRQFFGYGAVYAMPHFDFVSGWEVLTYLGLGLAAGMAGPLLLGLI 241

Query: 245 PRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLL 304
            R      + + P  +    G ++     I  P     G   +   +       +   L+
Sbjct: 242 DRARGAFARTRLPQALRLALGGLIVGALSIRVPEVWGNGYSVVNGFLHAPWLWQTVA-LV 300

Query: 305 AVIKLAALVVAAASGFRGGRIFPAVFVGVALGL----MLHEHVPA---VPAAITVSCAIL 357
            V K+ A   +A SG  GG   P +F G ALGL     +H  +P    VP +  V   + 
Sbjct: 301 LVCKVGATAASAGSGAVGGVFTPTLFCGAALGLLYGTGMHALLPGAAPVPVSYAVVG-MG 359

Query: 358 GIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWL 396
            ++   T    +S+ M   +  +  ++  L +  +  ++
Sbjct: 360 ALLAATTHAPLMSILMIFEMTLSYQVVLPLMLACITGYV 398


>UniRef50_Q1QSB4 Cl-channel, voltage gated n=1 Tax=Chromohalobacter salexigens DSM
           3043 RepID=Q1QSB4_CHRSD
          Length = 585

 Score = 91.0 bits (224), Expect = 7e-17,   Method: Composition-based stats.
 Identities = 58/356 (16%), Positives = 123/356 (34%), Gaps = 16/356 (4%)

Query: 11  LLSLPAVAIGIASSLILIVVMKIASVL-QNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIA 69
            L +  V  G+ +  +++    +  +     +    P            ++ ++ +    
Sbjct: 30  QLCVLGVLSGVLTGGLMVGFRGLLELGALAFMPGGDPEAFERLAGPVRVVLPLMAVG--L 87

Query: 70  VGLVIRFSQGHAG-----PDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIM 124
           +G+ +      AG                 +P           ++ L GG+S G E P +
Sbjct: 88  IGVWLWRMPNGAGKIGIGHVIERLTYHQGKMPLRNWMTQWWVGLVALLGGLSAGREGPAI 147

Query: 125 TVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLW 183
            +  A +  IG  + LP  +        +A  I A F TP+A  +   + +     +   
Sbjct: 148 HLGAAASSWIGQTMRLPHNSLRVLVGCGTAAGIAASFNTPIAGVIFAMEVVMMEYTIT-- 205

Query: 184 DRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWC 243
                 ++A+  GA+ + L +    S P      +++  +     +A  A+  G+VA   
Sbjct: 206 -GFMPVILASTTGAVVSQLVYG---SQPAFSVPSVQLASLFDLPWIAVTALLIGLVAGAF 261

Query: 244 LPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFL 303
           +        Q + PV    +   +         P     G D +++M+  +  +     +
Sbjct: 262 VRLAKPATWQTRWPVWGRFLAVGLAVGAVAWWYPQVQGMGYDSLERMLVGEP-ALDVLIV 320

Query: 304 LAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGI 359
           +A+ KLA   +A A G     I P +  G A G +       +   +  S  +  +
Sbjct: 321 VALGKLALTALAIAFGVPVSIIGPILVAGAAFGTLCGLLWATLLPGLASSPVVFSL 376


>UniRef50_C0R0D3 Puttaive chloride channel protein n=2 Tax=Brachyspira
           RepID=C0R0D3_BRAHW
          Length = 416

 Score = 91.0 bits (224), Expect = 8e-17,   Method: Composition-based stats.
 Identities = 65/403 (16%), Positives = 139/403 (34%), Gaps = 17/403 (4%)

Query: 6   ARTMLLLSLPAVAIGIASSLILIVVMKIASVLQ---NLLWQRLPGTLGIAQDSPLWIIGV 62
               + L + +  IG     I+ +   I   L      +   +            ++I +
Sbjct: 6   EVKYIKLFILSACIGAVVGFIISIYRIILYKLSVNVFYVSNFIFEKWYYPVLLFAFLIAM 65

Query: 63  LTLTGIAVGLVIRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHP 122
             L G  +    +              L         +   +   ++  A G+SLG   P
Sbjct: 66  GCLIGYILIHYPQIRGAGVPQIKYYISLHEPKNIFFEILFKLFGSMISFASGISLGRAGP 125

Query: 123 IMTVNIALAVAIGARLLPRVNRMEWTILASA-GTIGALFGTPVAAALIFSQTLN-GSSEV 180
            M V + + +              + +++ A   + A F  P        + L    + +
Sbjct: 126 SMHVGMLVGLFFHKYFSKLAKYRRYLLVSGACAGMTATFSAPFTGIAFSFEELGEHKNHI 185

Query: 181 PLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVA 240
                +F+ + +        G  F  +F+LP     +  ++ +  G I   +A     + 
Sbjct: 186 VFVCIVFSSIASILVIEHIVGQGFILNFNLPKILEVRHYISLLPFGIICGILASMLNFLM 245

Query: 241 VWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSD 300
            +       + + +  PV    + GF++     +  P  L  G   +  +V ++ FS S 
Sbjct: 246 NFFSKMYQKINNDIIRPVPAFLLAGFMI-----MFFPYVLGSGDLLIGSIVKDK-FSVSM 299

Query: 301 YFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVP------AVPAAITVSC 354
            F+L  +KL    V A SG  GG  FP   +G ++G +    +       AV   + +  
Sbjct: 300 LFILIFVKLFYTSVCATSGAVGGIFFPTFILGASIGSLYDIFLVKYFPDYAVYGDLFILL 359

Query: 355 AILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLL 397
            I  ++  +TR   +   +   +  + +    L IV + ++++
Sbjct: 360 GITSLMSGITRTPIMVCILILEISNSISNFSALVIVAIISYMV 402


>UniRef50_B1C8T2 Putative uncharacterized protein n=2 Tax=Clostridiales
           RepID=B1C8T2_9FIRM
          Length = 536

 Score = 91.0 bits (224), Expect = 8e-17,   Method: Composition-based stats.
 Identities = 65/384 (16%), Positives = 139/384 (36%), Gaps = 19/384 (4%)

Query: 5   RARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLT 64
           + R+ +   +    IGI + L+ I+   + +  + LL+  +    G      LW++ +  
Sbjct: 19  KGRSQIEFIIEGFLIGIVAGLVAIIYRLLLTKAEKLLFFAVDYIHGDVVKIILWMLFLTV 78

Query: 65  LTGIAVGLVIRFSQGHAGP-DPACEPLIGAPV---PPSALPGLIVALILGLAGGVSLGPE 120
           L  I VG ++++    +G   P     +   +   P   +   I+   L + GG+SLG E
Sbjct: 79  LA-IIVGKLVKWEPMISGSGIPQVSGEMKGYLSQNPVKVIIAKIIGGTLSIVGGLSLGRE 137

Query: 121 HPIMTVNIALAVAIGARLLPRVNRMEWTI-LASAGTIGALFGTPVAAALIFSQTLNGSSE 179
            P + +       +         + +  I   +   + A F  P+A  +   + ++ + +
Sbjct: 138 GPSIQLGAMAGKKLAQVQKKGKTKEKTYISCGAGAGLAAAFNAPLAGVMFTLEEIHKNFD 197

Query: 180 VPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMV 239
                 + + + AA          F             + +T      I+  I   +G  
Sbjct: 198 ---GRVIVSVMTAAVTADFLAKSVFGLSTVFQYNSSTPIPLTLYGLVIILGIIVGVSGAF 254

Query: 240 AVWCLPRLHAMMHQMK--NPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFS 297
              C+ +   +  ++K   P   + I   + G+  ++  P  L  G   M  ++    F 
Sbjct: 255 YNKCMVKGQKLYAKLKMIKPEYRIIIPFLVAGVFALVY-PKVL-AGGSVMVDILVKNNFV 312

Query: 298 TSDYFLLAVIKLAALVVAAASGFRGGRIFPAV----FVGVALGLMLHEHVPAVPAAIT-- 351
            S    + +IK    V+   SG  GG  +P +    F+G + G++    +      +   
Sbjct: 313 LSALLTMLIIKFLYSVICFGSGAPGGIFYPLLVLGSFIGASFGIVCISSLGVNDIFMDKF 372

Query: 352 VSCAILGIVLVVTRDGWLSLFMAA 375
           +  A+ G      R     + + A
Sbjct: 373 IILAMAGFFAATVRAPITGIILIA 396


>UniRef50_C1ZCM5 Chloride channel protein EriC n=1 Tax=Planctomyces limnophilus DSM
           3776 RepID=C1ZCM5_PLALI
          Length = 438

 Score = 91.0 bits (224), Expect = 8e-17,   Method: Composition-based stats.
 Identities = 77/387 (19%), Positives = 131/387 (33%), Gaps = 22/387 (5%)

Query: 40  LLWQ-RLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRFSQGHAGPDPACEPLI-GAPVPP 97
            LW   L      +    LW +         + L      G        E       +P 
Sbjct: 36  FLWLLDLATRTQQSSPYWLWSLPFWGAISAWLYLFFGREAGQGNNLVIAEIQHPMKGLPW 95

Query: 98  SALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARLLP--RVNRMEWTILASAGT 155
              P +++A IL   GG S G E   + +   LA        P    +  E  ++  A  
Sbjct: 96  FMAPLIVLATILTHLGGGSAGREGTAVQMGAGLAGIWARWTKPWLGEDYREILLMGVAAG 155

Query: 156 IGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGAL-TTGLFFHPHFSLPIAH 214
            G +FGTPVA A IF+  +     +P    L   L +  A  + TT    H H+ +  A 
Sbjct: 156 FGGVFGTPVAGA-IFAAEVLSVGRLPTSAILPCLLASCGADFVCTTVGGTHLHYPVDWAE 214

Query: 215 YGQMEMTDILSGA-IVAAIAIAAGMVAVWCLPRLHAMMHQM----KNPVLVLGIGGFILG 269
                    L    ++  +   AG+VA      LH           +P+  + +G  ++ 
Sbjct: 215 LNPSGWLHRLGIVGLIILLGAVAGLVAKGFSEGLHLAGRWYAKLLPDPIRRIAVGSLVVV 274

Query: 270 ILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLA-------VIKLAALVVAAASGFRG 322
            +         + GL      +   A +    F          + KL   ++  A G +G
Sbjct: 275 FVAEFVVGRD-YLGLGTTN--LNPHAVTIGSCFRAGGAHDWSWLCKLLLTILTLACGLKG 331

Query: 323 GRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTT 382
           G + P  F+G ALG +L      +P  +  +   + +    T    L+  + A+ +    
Sbjct: 332 GEVTPLFFIGAALGNVLAVKTGLLPVDVAAALGFVAVFSAATNAP-LASSVLAIELFGPD 390

Query: 383 LLPLLCIVMLPAWLLLAGKPMMMVNRP 409
            +  +      AWL+  G  +     P
Sbjct: 391 RIEYVFAACFSAWLVAGGSSIYSTQHP 417


>UniRef50_C6PDT2 Chloride channel core n=1 Tax=Thermoanaerobacterium
           thermosaccharolyticum DSM 571 RepID=C6PDT2_CLOTS
          Length = 521

 Score = 91.0 bits (224), Expect = 8e-17,   Method: Composition-based stats.
 Identities = 56/353 (15%), Positives = 129/353 (36%), Gaps = 16/353 (4%)

Query: 56  PLWIIGVLTLTGIAVGLVIRFSQGHAGP-DPACEPLIGAPVPP---SALPGLIVALILGL 111
           P+W++ ++ L GI    +++     +G   P  E  I                V  IL +
Sbjct: 65  PIWLVFLVAL-GIFTNYILKLEPMISGSGIPQVEGTIIGYFKLNWLKIFVLKFVGTILMI 123

Query: 112 AGGVSLGPEHPIMTVNIALAVAIGARLLP-RVNRMEWTILASAGTIGALFGTPVAAALIF 170
             G+SLG E P + +  +L   +   L   R          +   + A F  P+A  +IF
Sbjct: 124 GAGLSLGREGPCVQLGASLGQGVSRSLKRMRFEEKYLITCGAGAGLAAAFNAPLAG-VIF 182

Query: 171 SQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVA 230
           S      +  P+   L + ++++      T  F        I +   +  +  +   ++ 
Sbjct: 183 SLEELHKNFSPI--VLVSSMVSSLTATYITDTFLGLKTVFDITNLPIVPFSKYIYLLVLG 240

Query: 231 AIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQM 290
            +    G++    L +   + ++      +      ++ ++  +  P+ L  G   + ++
Sbjct: 241 VVIGLGGILFNKSLLKSQDLYNKYVKIPQLKIFIPLLVSVIVGLSIPMVLGGGESLVDKI 300

Query: 291 VANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLH------EHVP 344
            ++     +   LL + K    +V+  SG  GG   P + +G  +G +         ++ 
Sbjct: 301 -SSVNLGFAFVILLLISKFLFTMVSYGSGVPGGIFMPLLAIGALIGNLYGIIIIHIFNID 359

Query: 345 AVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLL 397
            +     +  A+ G    + R       +   +  + + L  L  V + A+++
Sbjct: 360 QLYLKDFIVLAMAGYFAAIVRAPITGSLLVTEMTGSFSHLLALSTVSITAYIV 412


>UniRef50_D0BMA2 Voltage-gated chloride channel protein n=1 Tax=Granulicatella
           elegans ATCC 700633 RepID=D0BMA2_9LACT
          Length = 404

 Score = 90.6 bits (223), Expect = 1e-16,   Method: Composition-based stats.
 Identities = 70/382 (18%), Positives = 143/382 (37%), Gaps = 13/382 (3%)

Query: 21  IASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRFSQGH 80
           +   ++ I+V  I  VL +   Q L     +  +   ++I  L + G     V      +
Sbjct: 11  VLLGIVSIIVGVITGVLTSFFGQVLLKVSELRVEYFAYLIPFLAVVGFLFHTVYLKYGKN 70

Query: 81  AGPDPACEPLIGA----PVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGA 136
           A         IG      +    +P +++   L    G S+G E   + +   +A     
Sbjct: 71  AVEGMNIVFRIGQGEDNRISKWLIPFMMIGTWLAHLFGASVGREGVAVQLGATVANQFQQ 130

Query: 137 RLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAG 196
               + NR    ++  A     LFGTP+AA   F+  +    ++ + D LF  L+++   
Sbjct: 131 WFSSKRNRQILLMIGMASGFAGLFGTPLAAT-FFAIEVMIVGQLQI-DALFYALLSSFIS 188

Query: 197 ALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKN 256
                      F + I    Q + T +    +  A  +   + +V          +++ +
Sbjct: 189 MNVAQRLGLEKFMVGILVDIQFDETLLKMVVLGIAFGLTGRLFSVSLAYLKKYWSNKIPS 248

Query: 257 PVLVLGIGGFILGI-LGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVA 315
           P L + + G  + I +   G       G + +     ++     D+      KL   V +
Sbjct: 249 PTLRIFLLGIGVSILIAAFGSGRYAGLGTNLIHASFYSETIFVQDWL----FKLGLTVFS 304

Query: 316 AASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLVVTRDGWLSLFMAA 375
            ++GF GG + P   +G +LG+++   +   P  +  +    G V     + WL+     
Sbjct: 305 LSAGFLGGEVTPLFSIGSSLGIVMSSWLGISP--MVAAALGYGAVFGSATNTWLAPIFII 362

Query: 376 VVVPNTTLLPLLCIVMLPAWLL 397
             V   +++P   IV + A+++
Sbjct: 363 GEVFGYSMMPYAAIVCIVAFVV 384


>UniRef50_D1NB42 Cl-channel voltage-gated family protein n=1 Tax=Victivallis
           vadensis ATCC BAA-548 RepID=D1NB42_9BACT
          Length = 609

 Score = 90.6 bits (223), Expect = 1e-16,   Method: Composition-based stats.
 Identities = 65/372 (17%), Positives = 132/372 (35%), Gaps = 36/372 (9%)

Query: 56  PLWIIGVLTLTGIAVGLVIRFSQGHAGPDPACEPLIGA------PVPPSALPGLIVALIL 109
              ++ +L + G+    V++   G      +  PLI A       +P   +   +++  +
Sbjct: 79  WFAVLFILPMLGLLGSFVVQRFLGGPRYAKSLSPLILALNRKRTNIPAVEMINHMLSSAI 138

Query: 110 GLAGGVSLGPEHPIMTVNIALAVAIGARLLPRVNRMEWTI-LASAGTIGALFGTPVAAAL 168
            +  G S G E P +    A+     + L          +   SA  I A+F +P+A  L
Sbjct: 139 SVGFGGSAGLEAPSVLTGAAIGANSASFLHIDRRHRSLLLGCGSAAAISAIFDSPIAGVL 198

Query: 169 IFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAI 228
             ++ L     V     L   +M++A  A+ +           +A     +   +    +
Sbjct: 199 FAAEVLLPEFSV---SALVPMMMSSAVAAVVSRQIMGDT-QFILAINAPWQANAVPCYFL 254

Query: 229 VAAIAIAAGMVAVWCLPRLHAMM-HQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEM 287
                   G+  +         + H+ +N    L +GG +L +L ++  P+   +G   +
Sbjct: 255 CGIFCALVGVYVIKTAYFTGDWLKHKFRNAWQRLFVGGSVLCVL-LLLFPMMRGQGYLYI 313

Query: 288 QQMV------------------ANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAV 329
           +++                   +          ++ ++K+   V+   +G  GG   P++
Sbjct: 314 EKLFAGDTAGLVASSPLLHWIPSETGILVLLLVVVLLLKVVVSVLTVDAGGDGGIFAPSM 373

Query: 330 FVGVALGLMLHEHVPAVPAAIT-----VSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLL 384
           F+G   G +    V             V+  + G+   V R     +F+ A V  +  LL
Sbjct: 374 FIGAFAGFVFARVVNLTGLIQLQEYNFVAVGMCGVFTAVMRAPLTGIFLIAEVTGSYILL 433

Query: 385 PLLCIVMLPAWL 396
             L IV   AW 
Sbjct: 434 VPLMIVSSVAWF 445


>UniRef50_C0RHJ6 Chloride channel core protein n=2 Tax=Brucella melitensis bv. 2
           RepID=C0RHJ6_BRUMB
          Length = 512

 Score = 89.8 bits (221), Expect = 2e-16,   Method: Composition-based stats.
 Identities = 59/322 (18%), Positives = 118/322 (36%), Gaps = 19/322 (5%)

Query: 19  IGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRFSQ 78
           IGI  +  LI ++   +V            + +   + +  +    L G+ + ++ R+ +
Sbjct: 38  IGIVIAGALIGILSGLAV----------AAIQLYPSAFIAPMAGGILMGVLIWVLARWRK 87

Query: 79  GHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARL 138
                      L G  +  +    L+   ++    G S+G E     +    A  IG  L
Sbjct: 88  RPIVDPIEANALHGGRLSLTDSFILVGQNLISKGFGASVGLEAAYTQLASGFASRIGRAL 147

Query: 139 -LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGA 197
            L R +        +A  I + F  P+  +    + + G   +     L   ++AA  G 
Sbjct: 148 KLRRADMRTLVGCGAAAAIASAFNAPLTGSFYAFELIIGVYSIA---TLAPVVVAAIIGT 204

Query: 198 LTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNP 257
           L T       F + I     +   D +   ++  I+    ++ +  +  +  +    +  
Sbjct: 205 LVTQAIGGAPFIIDIGLIDDITPRDYVPALMLGFISAGIAILIMRGVTLVEKVA---RRS 261

Query: 258 VLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAA 317
           V+   +   I+G++     P  L  G   +  +  N   +     LL + K  A  V+  
Sbjct: 262 VVPNVLAPAIVGMIA-FFSPQVLASGHGALH-LDLNANITIPVLVLLILTKSLASAVSIG 319

Query: 318 SGFRGGRIFPAVFVGVALGLML 339
           SGFRGG  F ++F+G  +   L
Sbjct: 320 SGFRGGLFFASLFLGAVVSSSL 341


>UniRef50_B6JH96 Voltage-gated chloride channel n=1 Tax=Oligotropha carboxidovorans
           OM5 RepID=B6JH96_OLICO
          Length = 446

 Score = 89.4 bits (220), Expect = 2e-16,   Method: Composition-based stats.
 Identities = 56/318 (17%), Positives = 115/318 (36%), Gaps = 5/318 (1%)

Query: 93  APVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARLLPRVNRMEWTI-LA 151
             +P   LP   +A I+ LA G S G E P   +  +L  AIG          +  +   
Sbjct: 95  GRMPFLTLPIKPIAAIITLASGGSAGKEGPCSHIGASLGAAIGQVFHLNSELRQRIVACG 154

Query: 152 SAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLP 211
            +    ++FGTP+A A+   + L         D LF  ++A  A    +  +  P+   P
Sbjct: 155 VSAGFASVFGTPIAGAIYGVEVLAIGRI--RHDFLFPAVIAGIASYQVSLFWGVPYTYYP 212

Query: 212 IAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGIL 271
            A          L  A++  +     ++ V  + R  A+   ++    +      + G +
Sbjct: 213 FAAPPAFSEILFLKIALLGVVCGVISLIFVELVHRARALRAHLQMRFDIWPPLMPLFGGI 272

Query: 272 GVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVI-KLAALVVAAASGFRGGRIFPAVF 330
            +    + +      +   + ++A +     LL  + K   + +   SGF GG + P   
Sbjct: 273 LLALLILVIPTDYLGLSLPLMDRALAGESMPLLGFLWKSLLVAITIGSGFYGGIVTPQFV 332

Query: 331 VGVALGLMLHEHVPAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIV 390
           +G   G  L   +   P  +  +  ++ +V   +     ++ M   +             
Sbjct: 333 IGAVAGNALAYWLGLSPL-LGAAAGLVSVVAASSNTPVAAILMGVELFGGAVGTLYTAGA 391

Query: 391 MLPAWLLLAGKPMMMVNR 408
            + A+L++  + +    R
Sbjct: 392 AMAAYLMIGHRSIYPEQR 409


>UniRef50_Q3DFX6 Voltage-gated chloride channel family protein n=7 Tax=Firmicutes
           RepID=Q3DFX6_STRAG
          Length = 398

 Score = 89.4 bits (220), Expect = 2e-16,   Method: Composition-based stats.
 Identities = 68/393 (17%), Positives = 136/393 (34%), Gaps = 25/393 (6%)

Query: 9   MLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGI 68
            +L+   ++ IG     I  V  ++   L                D   +++  L++ G+
Sbjct: 11  YVLVLGFSLLIGGVVGAITAVFGRVLLFLTAF-----------RSDYIAYLLPFLSIVGL 59

Query: 69  AVGLVIRFSQGHAGPDPACEPLIG----APVPPSALPGLIVALILGLAGGVSLGPEHPIM 124
            +  V +   G +         +G      +P   +P +I+   L    G S G E   +
Sbjct: 60  FIVFVYQKFGGKSVKGMGLVFEVGHGNEETIPKRLVPLVILTTWLTHLFGGSAGREGVAV 119

Query: 125 TVNIALAVAIGARLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWD 184
            +   ++         +     + ++  A     LF TP+AA     + L     +  + 
Sbjct: 120 QIGATVSHYFQKYCRLQNASQLFLVMGMAAGFAGLFQTPLAATFFAIEVLVVGRLMVSY- 178

Query: 185 RLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCL 244
            +   L+AA      +       FS  IA    +    IL   ++       G +  + L
Sbjct: 179 -VLPSLIAALTANFVSHSLGLEKFSHSIATSMALTPDIILKLLVLGLCFGLCGNLFAYLL 237

Query: 245 PRLHAMM-HQMKNPVLVLGIGGFILG-ILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYF 302
            +   +   ++ NP   +   G +   +L +         G + ++    N+     D+ 
Sbjct: 238 AKAKLIASSRLLNPYKRIFTLGLLATFLLFIFHFGRYSGLGTNLIEASFTNKNLYDYDWL 297

Query: 303 LLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLV 362
           L    KL   V+  A+G++GG + P   +G +LG+++   +      I V+      V  
Sbjct: 298 L----KLCLTVITLAAGYQGGEVTPLFAIGASLGVIIAPILGL--PVILVAALGYTSVFG 351

Query: 363 VTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAW 395
              +  L   +    V      P   IV L A+
Sbjct: 352 SATNTLLGPILIGGEVFGFANTPYFVIVCLVAY 384


>UniRef50_C8WC17 Chloride channel core n=5 Tax=Proteobacteria RepID=C8WC17_ZYMMN
          Length = 479

 Score = 89.4 bits (220), Expect = 2e-16,   Method: Composition-based stats.
 Identities = 63/296 (21%), Positives = 110/296 (37%), Gaps = 17/296 (5%)

Query: 63  LTLTGIAVG-LVIRFSQGHAGPDPACEPLIGAP---VPPSALPGLIVALILGLAGGVSLG 118
           L + G        R+ +  AG +      I  P   VP    P + ++ ++    G S G
Sbjct: 58  LPIAGFITSWFYSRYGKLAAGGNNLILEEIHKPNAGVPLRMAPLIFISTVITHLFGGSAG 117

Query: 119 PEHPIMTVNIALAVAIGARLLPRVNRMEWTIL-ASAGTIGALFGTPVAAALIFSQTLNGS 177
            E   + +  ++A  IG         +   ++   A   GA+FGTPV  A IF+  +   
Sbjct: 118 REGTAVQLGGSIASGIGKIAGLDKKDIRLLLISGIAAGFGAVFGTPVTGA-IFALEVPVI 176

Query: 178 SEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQME--MTDILSGAIVAAIAIA 235
             +     L   L AA  G     L+   H    +A + QM     +I+    V   +IA
Sbjct: 177 GRLEYR-ALIPALTAAILGDWVCRLWGMDHLRYSMASFSQMGHFQLNIILFFKVILASIA 235

Query: 236 AGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQA 295
            G++A      L       K  +    +  F  G++ +    ++  +    +  + A   
Sbjct: 236 FGVIARLFSESLANSAQWFKKVIPSAPLISFTGGLIVIALVYITGTRDYLGIGTIAAQPN 295

Query: 296 FSTSDYFL--------LAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHV 343
                 F           ++K    VV  ++GF+GG + P  F+G ALG  +   +
Sbjct: 296 GLQLGSFFDPQQHHYWSWLLKFIFTVVTLSTGFKGGEVTPLFFIGAALGSTIAHII 351


>UniRef50_B5ZGR7 Chloride channel core n=11 Tax=Bacteria RepID=B5ZGR7_GLUDA
          Length = 457

 Score = 89.4 bits (220), Expect = 2e-16,   Method: Composition-based stats.
 Identities = 73/387 (18%), Positives = 128/387 (33%), Gaps = 24/387 (6%)

Query: 41  LWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRFS--QGHAGPDPACEPLI--GAPVP 96
           L+  L   +   +     ++  L L G+AVGL       Q   G +   + +   G  VP
Sbjct: 52  LFLWLLDRVTDDRLHHPDLLYALPLAGVAVGLTYHVLGRQAEGGNNLIVDQIHEPGGGVP 111

Query: 97  PSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGT 155
               P ++   ++    G S+G E   + +  ++A        L             A  
Sbjct: 112 LRMAPLVLAGTVVSHLFGASVGREGTAVQIGGSIASGFTRLFRLTAREVRTLLTAGIAAG 171

Query: 156 IGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHY 215
            G +FGTPVA A+   + L+            A    AA          H  ++LP   Y
Sbjct: 172 FGGVFGTPVAGAVFAMEVLSIGRMEYSAIVPVAVAAIAADWTCHAWGIHHVTYTLPFRGY 231

Query: 216 GQMEMTDILSGAIV----AAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGIL 271
                T   +  ++    AA  +A G+ ++     +H +    +    V  +   I G+L
Sbjct: 232 PDAGGTAFHADPLLLARVAAAGVAFGLASLAFAQAVHRLGAVFRALCPVAWLRPAIGGVL 291

Query: 272 GVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVI----------KLAALVVAAASGFR 321
            ++   +    G  +   +            L              KLA  V A A+GF+
Sbjct: 292 TIV---LVFLAGSRDYLGLGITAPEPGGASILDFFGPAHYAWSWLWKLAFTVAALATGFK 348

Query: 322 GGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNT 381
           GG + P  F+G  LG  L   + A P  +  +   + +             M   +    
Sbjct: 349 GGEVTPLFFIGAGLGNALAPLLHA-PVDLLAAVGFVAVFAGAANTPLACTLMGIELF-GA 406

Query: 382 TLLPLLCIVMLPAWLLLAGKPMMMVNR 408
             +  L +    A+L      +    R
Sbjct: 407 ADIVYLAVGCFVAYLCSGHSGIYRAQR 433


>UniRef50_C8WAP8 Chloride channel core n=2 Tax=Atopobium RepID=C8WAP8_ATOPD
          Length = 528

 Score = 89.1 bits (219), Expect = 3e-16,   Method: Composition-based stats.
 Identities = 59/347 (17%), Positives = 117/347 (33%), Gaps = 15/347 (4%)

Query: 62  VLTLTGIAVGLVIRFSQGHAGP-DPACEPLIGAPVP---PSALPGLIVALILGLAGGVSL 117
           +L +  IAV L+++F    +G   P     +           LP   +  +L   GG+S+
Sbjct: 73  ILLILMIAVCLLMKFEPYTSGSGIPQTNAEVMGSADMPWYRVLPVKFIQGVLVAFGGLSM 132

Query: 118 GPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNG 176
           G E P + +      A+   L   R          +A  + A F  P+   L   + +  
Sbjct: 133 GREGPSVQLGAVSGKAVSKLLKRKRGEERLLVTCGAAAGMSAAFHAPLTGTLFAIEEIQK 192

Query: 177 SSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAA 236
               PL   + + + A+                L + +   +   D      V  I    
Sbjct: 193 EFHAPL---IISAMTASVGADFLVSNVLGMKPVLQLPYVAPLPHVDYAFVLFVGVICGLL 249

Query: 237 GMVAVWCLPRLHAMMHQMKNPV-LVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQA 295
           G +    +     +  ++   V     I  F+L  +     P  L  G   ++++    A
Sbjct: 250 GALHNKGMFFAQRLYKKITKFVPFSRLIIPFMLAGIMAFTWPDLLCGGDAIIEKIKEPAA 309

Query: 296 FSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEH------VPAVPAA 349
            +     +L + K        A+G  GG +FP V +G  +G +          +P   A 
Sbjct: 310 LTELMVIVLLLGKYFFTTTCFAAGTPGGTLFPMVVMGTLVGTLFALVATHIFGIPMAYAP 369

Query: 350 ITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWL 396
             ++  + GI     R     + +   +  +   L  +  V + +++
Sbjct: 370 NFIAMGVAGIFAGAVRAPVTGVVLIFELTGSLEALMAMSAVAIVSYV 416


>UniRef50_D2UEG8 Probable chloride channel protein n=1 Tax=Xanthomonas albilineans
           RepID=D2UEG8_XANAL
          Length = 468

 Score = 89.1 bits (219), Expect = 3e-16,   Method: Composition-based stats.
 Identities = 64/284 (22%), Positives = 113/284 (39%), Gaps = 10/284 (3%)

Query: 116 SLGPEHPIMTVNIALAVAIGARLLPRVNRMEWTIL--ASAGTIGALFGTPVAAALIFSQT 173
           S+G E P + V  +L    G     R +R     L    A  I A F TP+A  +   + 
Sbjct: 134 SIGREGPTVHVGASLMYVFGRWFGFRDSRHASHFLLAGGAAGIAAAFNTPLAGVVFAIEE 193

Query: 174 LNGSSEVPLWDRLFAPLMAAAA---GALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVA 230
           L+G  E      L   ++       G L    +F    +  +          +       
Sbjct: 194 LSGRFEHHFSGTLLTAVIVGGVISLGLLGNYTYFGKVATAGLPLGEAWLAILLCGVVAGL 253

Query: 231 AIAIAAGMVAVWCLPRLHAM-MHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQ 289
                A MV      + H +   + ++PVL+  + G  L +LG++ G  +   G ++ + 
Sbjct: 254 LGGGFARMVLATVGGKPHWLGALRRQHPVLLAALCGLTLVVLGLVFGAGAFGTGYEQARS 313

Query: 290 MVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAA 349
           +V   A    ++    ++KL A +V+  +G  GG   PA+ VG  LG  L   +P V   
Sbjct: 314 LVQGHASVGHEF---GLMKLLANLVSYVAGIPGGLFSPALAVGAGLGHNLAVLMPGVDPR 370

Query: 350 ITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTL-LPLLCIVML 392
             V   +   +  VT+    S  ++  +  ++ + LP+L  VM+
Sbjct: 371 TFVLLGMCAYLTGVTQAPLTSAVISLELTDSSNMLLPILATVMI 414


>UniRef50_B0R5U8 Chloride channel n=2 Tax=Halobacterium salinarum RepID=B0R5U8_HALS3
          Length = 792

 Score = 89.1 bits (219), Expect = 3e-16,   Method: Composition-based stats.
 Identities = 84/418 (20%), Positives = 142/418 (33%), Gaps = 45/418 (10%)

Query: 6   ARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRL--PGTLGIAQDS-------- 55
           +R  + L+  A+ +GI + L  +V        Q + +     PG +  A           
Sbjct: 174 SRDGVRLNTAAILVGIVAGLGAVVFRITIFAAQAVFFGATLNPGAVSFAPIHVPNLFGAL 233

Query: 56  ----PLWIIGVLTLTGIAVGLVIRF----SQGHA-GPDPACEPLIGAPVPPSALPGLIVA 106
               PL    V  + G+ VGLVIR      +GH          +    + P       V+
Sbjct: 234 APLGPLRYALVPAVGGLIVGLVIRRTTTAIRGHGVPEVLESLMVHNGQIDPKIAVYKTVS 293

Query: 107 LILGLAGGVSLGPEHPIMTVNIALAVAIGARLLPRVNRMEWTILASAGTIGALFGTPVAA 166
             + +A G SLG E PI+ +  A     GA +  R          +   I A F TP+A 
Sbjct: 294 SSIAIASGASLGREGPIVQIGSAAGSYFGAFVHSRYT-RTLVAAGAGSGIAATFNTPLAG 352

Query: 167 ALIFSQTLNGSSEV-PLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILS 225
            +   + L     +  +   + + + A A           P     +       +T  L 
Sbjct: 353 VMFALEILLSEYALTNVVTVVLSAVTATAVARSVLAFTAVPGVREFLVPITYHIVTPSLE 412

Query: 226 GAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNP-----VLVLGIGGFILGILGVIGGPV-- 278
             + A + + A  +    +  L+A  H  ++       L   IGG +LG+  ++   +  
Sbjct: 413 FPLYAGLGVVAAGIGAAVVRLLYASEHLFQDRWDLPGYLTPAIGGALLGVSVLLTAVLLD 472

Query: 279 ---------SLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAV 329
                        G   +   +A    +      LAV+K+    ++  SG  GG   P +
Sbjct: 473 ASPLQSATWLFGVGYGTIHSSIAG-DLTLLVLVALAVLKVVGFSLSIGSGNSGGVFSPTL 531

Query: 330 FVGVALGLMLHEHVPAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLL 387
           +VG   G      V A  A    + A   +       G   +F A    P T  L + 
Sbjct: 532 YVGAMAGGAFGVLVNAAFAGTASAGAYALV-------GTAGVFAATASAPLTATLIIF 582


>UniRef50_D1NS75 Chloride transporter, chloride channel family n=1
           Tax=Bifidobacterium gallicum DSM 20093
           RepID=D1NS75_9BIFI
          Length = 497

 Score = 89.1 bits (219), Expect = 3e-16,   Method: Composition-based stats.
 Identities = 60/365 (16%), Positives = 116/365 (31%), Gaps = 24/365 (6%)

Query: 53  QDSPLWIIGVLTLTGIAVGLVIR--FSQGHAGPDPACE-PLIGAPVPPSALPGLIVALIL 109
                W+I  L   G+   L+ +      +   +   +    G P+     P +I++  +
Sbjct: 60  FQHHHWLIWTLPAMGVLEILLYQWWKIPANTTTESVIDRIRTGKPITILLAPAIILSTAM 119

Query: 110 GLAGGVSLGPEHPIMTVNIALAVAIGARLLPRV-----------NRMEWTILASAGTIGA 158
            +  G S+G E   + +  +L   +G     R                      A    A
Sbjct: 120 SIFSGGSVGKEAGALQLGGSLGYTVGKPFHLRNVFYEREDGAMFTNRYTAATGMAAAFSA 179

Query: 159 LFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQM 218
           LF +P+ + +   + L+         R  A ++ A   A      F     +       +
Sbjct: 180 LFFSPLGSLMFIYELLHFQC-----LRYVASMLVACFVAYFVARTFGIGDIITKVAIPHI 234

Query: 219 EMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPV 278
           +   I    I+       G +  + +  LH +  ++     +  I G  +    VI    
Sbjct: 235 DWQIIGFCIIIGVACALGGSIFSFFVRLLHEITERISTRYWIWTIIGGAIVTALVISCDW 294

Query: 279 SLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLM 338
             F G       + N+A +TS+       K+   ++     F+GG I  ++ +G  LG  
Sbjct: 295 WKFSGTG---GELLNEALATSNVSWDFAPKMVLSILCLGMWFKGGEIMVSLCMGGLLGSA 351

Query: 339 LHEHVPAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL 398
                   P       A+            L+ F+    +    +  LL I +  A+L  
Sbjct: 352 CSVMTGCDPLLGAALGAMC--FFAAFDRCPLAAFLMGCEIFGWGMWALLAISVFVAFLFS 409

Query: 399 AGKPM 403
               M
Sbjct: 410 YPVGM 414


>UniRef50_A5G2G7 Cl-channel, voltage-gated family protein n=1 Tax=Acidiphilium
           cryptum JF-5 RepID=A5G2G7_ACICJ
          Length = 606

 Score = 89.1 bits (219), Expect = 3e-16,   Method: Composition-based stats.
 Identities = 83/404 (20%), Positives = 149/404 (36%), Gaps = 27/404 (6%)

Query: 12  LSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPG-TLGIAQDS---PLWIIGVLTLTG 67
           L++ A  +G+ S   + ++  ++    +  +  LP    G++Q +   PL  I V  L G
Sbjct: 44  LAMLAAVVGVLSGFCVYLMDFLSHHF-HFWFFALPNLDEGLSQQTHIDPLRAIFVPILGG 102

Query: 68  IAVG----LVIRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPI 123
             +G    L+ R+   +         L G  +       + +        G S+G E   
Sbjct: 103 AVLGSVAWLLGRYRMTNFVDPVEANALYGGKMSLRDSIIVAMQTSFSNGVGGSVGQEAGY 162

Query: 124 MTVNIALAVAIGARLLPRVNR-MEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPL 182
                 LA  +G  L  R N         +   IG  F  P+  A    + + G+  +P 
Sbjct: 163 AQFGGGLASWVGQHLRLRRNDLRVLVGCGAGAAIGGAFNAPLCGAFYGIELVIGTYSLP- 221

Query: 183 WDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILS--GAIVAAIAIAAGMVA 240
              L   ++++ +G L   L  +     P+                 ++  IA   G+  
Sbjct: 222 --TLTMVVISSLSGTLAVELLMNGGVR-PLNVVLPTHTPGYAYPLAVLLGIIAGFVGIAI 278

Query: 241 VWCLPRLHAMMHQMKNPV-LVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTS 299
           +  +  L A+  +   P+ L   IGG ++G+LG I  P  +  G   +   +A   +   
Sbjct: 279 MRAVTSLEAVFRRTGVPIWLRPIIGGVVVGLLGSIT-PKVMASGNSSLHTQLA-VVYPFM 336

Query: 300 DYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGI 359
               L V+K  A   + A+GFRGG  F A+F+G  LG    +    +P A  V      +
Sbjct: 337 LAVALLVMKSTASAFSIATGFRGGLFFAALFMGSLLGRAYGDVAVMLPFAHGVPIGFYAV 396

Query: 360 VLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPM 403
           V +          +A  +V  T  +  L +     + +     M
Sbjct: 397 VGMA--------ALATSIVSGTMTMTFLTLESTNNFSITIAVLM 432


>UniRef50_Q2S8Y1 Chloride channel protein EriC n=4 Tax=Gammaproteobacteria
           RepID=Q2S8Y1_HAHCH
          Length = 601

 Score = 89.1 bits (219), Expect = 3e-16,   Method: Composition-based stats.
 Identities = 58/346 (16%), Positives = 122/346 (35%), Gaps = 15/346 (4%)

Query: 59  IIGVLTLTGIAVGLVIRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLG 118
           I+G L L    + L ++  +                +   +        +  LA G S G
Sbjct: 92  IVGALILALWLMRLGVQQRKVGVTHVMERLGYHQGYISLRSGLLQFFCGVATLATGQSAG 151

Query: 119 PEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGS 177
            E P + +    +  +G  + LP  +        +A  + A F TP+A  +   + +   
Sbjct: 152 REGPAVHLGATSSSLLGQWMGLPNNSIRMLVGCGTAAAVSASFNTPIAGVIFAMEVVMLE 211

Query: 178 SEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAG 237
             +  +      ++AA   A+ +   +    +  + ++    + ++     VA +     
Sbjct: 212 YTINGFT---PIILAAVTAAVVSQPIYGNDPAFIVPNFSLNSLVELPYIVAVAILIGMCS 268

Query: 238 MVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFS 297
            + V  + +    M ++K P+L   +    L  L  +  P  +  G D +   +A     
Sbjct: 269 ALFVKIISQT---MEKVKTPILCRLLAAGFLTGLAALALPQIMGIGYDTVNDAIAGN-IG 324

Query: 298 TSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVS---C 354
                 +A+ KL         G   G I P +F+G  LG  L      +   +       
Sbjct: 325 FLLLLAIALAKLLVTATTIGLGMPSGIIGPTLFIGATLGGALGVLANMLMPTLASEPGFY 384

Query: 355 AILGIVLVVTRDGWLSLFMAAVVVPNT----TLLPLLCIVMLPAWL 396
           A+LG+  ++       L     V+  T     +LP + I+++ + +
Sbjct: 385 AVLGMGAMMGSVLQAPLAAIMAVIELTRNPNVILPAMLIIIVSSLI 430


>UniRef50_C1EDM4 Chloride Carrier/Channel family n=1 Tax=Micromonas sp. RCC299
           RepID=C1EDM4_9CHLO
          Length = 850

 Score = 89.1 bits (219), Expect = 3e-16,   Method: Composition-based stats.
 Identities = 53/321 (16%), Positives = 108/321 (33%), Gaps = 44/321 (13%)

Query: 106 ALILGLAGGVSLGPEHPIMTVNIALAVAIGARLLPRVNRMEWTILA-----SAGTIGALF 160
           A ++ L  G SLGPE P + +  ++A  +        +      L      SA  I A F
Sbjct: 195 AAVVTLGSGASLGPEGPSVEIGASVAGGVSELANVTSSAKTAQRLGLIAAGSAAGISAGF 254

Query: 161 GTPVAAALIFSQTL----NGSSEVPLWDRLF----------APLMAAAAGALTTGLFFHP 206
           G P+A      +++         +P                + ++A+   A+ +      
Sbjct: 255 GAPIAGLFFAFESILQPAASRGSLPTRGGGGSTGFGPLTTESVILASVLAAVVSNQILGD 314

Query: 207 HFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKN---------- 256
             +  +  +      ++     +  +  A  +        L    + ++           
Sbjct: 315 TPAFVVPAFDIRAAAELPLYLPLGFLCGATAVAFRASSSALGNAFNALERGDGGAGGSRW 374

Query: 257 ----PVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQA------FSTSDYFLLAV 306
                     +GGF+ G++  +  P   ++G D +  ++  +       +       L +
Sbjct: 375 GGVPREWHAPLGGFVFGLVA-LYFPEVTYQGFDNVNSILNAEGSAFRLPYPPDLLLELVL 433

Query: 307 IKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLVVTRD 366
           +K+A+  +   SG  GG   P++F+G ALG      +  VP A+            +   
Sbjct: 434 VKIASTALCRQSGLVGGVYAPSLFMGAALGSAYGAAL--VPLALAGVPVAAPQAYALV-- 489

Query: 367 GWLSLFMAAVVVPNTTLLPLL 387
           G   +      VP T +L L 
Sbjct: 490 GMAGVLAGICRVPLTAILLLF 510


>UniRef50_B0S0E6 Chloride channel protein n=2 Tax=Finegoldia magna
           RepID=B0S0E6_FINM2
          Length = 512

 Score = 88.7 bits (218), Expect = 3e-16,   Method: Composition-based stats.
 Identities = 72/403 (17%), Positives = 148/403 (36%), Gaps = 25/403 (6%)

Query: 10  LLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIA 69
           + L L +++IG+ S  + +    + S L  ++   +       +   + II V  + GI 
Sbjct: 11  MSLFLASLSIGVFSGGLAVFYRFLLSKL-EVVRNTIYSNNSFPRA--ILIIAVSFVLGIC 67

Query: 70  VGLVIRFSQGHAGP-DPACEPLIGA-------PVPPSALPGLIVALILGLAGGVSLGPEH 121
           V  +++++    G   P  +  +          V  S + G  +A ++GL    SLG E 
Sbjct: 68  VSKLLKWAPLSGGSGIPQVQGELIGAFNQNSFRVTVSKIVGGAIASLVGL----SLGREG 123

Query: 122 PIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEV 180
           P + +  + A  +  +    +     +    +A  + A F  P++  +   + L+ S   
Sbjct: 124 PSIQLGASSAKWLSEKFGKSKTEEKLYLTAGAAAGLSAAFSAPISGLVFILEELHKSFSK 183

Query: 181 PLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVA 240
            +    F+  + A   A+       P FS  + H   +     L    +  I    G + 
Sbjct: 184 KVVAISFSAAVIADVIAVWV-FKIKPVFSFGMTHV--LPTKYYLLIFPMIIICSVVGKLF 240

Query: 241 VWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSD 300
              +     +  ++K    +     F    +  +     L  G   ++ M  +   S   
Sbjct: 241 NCSITFFQDIFAKIKLEQDIKIAIFFAFVSVVGLFYKDILGGGHSFIENMATHNYNSFFV 300

Query: 301 YFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHE------HVPAVPAAITVSC 354
             +L + K+     + A+G +GG   P + +G   GL           V  V  +  V  
Sbjct: 301 LIILLLFKMFMTSTSYATGTQGGIFLPVLVLGGITGLFYFNLMSAFGFVQDVYLSNFVVL 360

Query: 355 AILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLL 397
           A++ ++  V R   LS+ +   +  N T L  L    + A+ +
Sbjct: 361 AMVCVLTAVVRSPLLSVVLVLELNGNMTHLLGLAFCSIMAYFI 403


>UniRef50_C5VYM9 Voltage gated chloride channel protein n=5 Tax=Streptococcus suis
           RepID=C5VYM9_STRSE
          Length = 404

 Score = 88.7 bits (218), Expect = 4e-16,   Method: Composition-based stats.
 Identities = 75/398 (18%), Positives = 141/398 (35%), Gaps = 24/398 (6%)

Query: 5   RARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLT 64
           + +  + L   +  IG+ + +I  +  KI           L G   +  +   ++I  L 
Sbjct: 4   KMKHAIQLLFFSSLIGVGAGIITTLFGKI-----------LLGIGDLRSEYFTYLIPFLP 52

Query: 65  LTGIAVGLVIRF----SQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPE 120
           L G+ +  + +      Q   G          A + P  +P +I    L    G S+G E
Sbjct: 53  LAGVLIVFIYQKWGREVQAGMGLVFKAGQGEKAQISPVLIPLIISTTWLSHLVGASVGRE 112

Query: 121 HPIMTVNIALAVAIGARLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEV 180
              + +  +L+  +       + +   T +  A     LF TP AA     + L      
Sbjct: 113 GVAVQLGASLSHWLQKHGFTHLPKDMITKIGMAAGFAGLFQTPWAAGFFAIEVL--IVGQ 170

Query: 181 PLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVA 240
             W  L   L+AA   + T+ L     FS  IA              I         + A
Sbjct: 171 YSWTSLPYCLVAAFTASTTSHLLGLEKFSHTIATTSFYFTDSFKWLFIALCFGFIGNLFA 230

Query: 241 VWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSD 300
           ++           + NP + + I G  L +L +       + G   +   + + + +   
Sbjct: 231 LFLAQAKSISTRWLPNPYIKIAIMGVGLTVL-LFFFHQGRYTG---LGTNLIDASLAGEQ 286

Query: 301 YFLLA-VIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGI 359
            F    ++KL    +  A+GF+GG + P   +G + G +L   +  +P  +  +     +
Sbjct: 287 VFAFDWLLKLLLTCLCLAAGFQGGEVTPLFAIGASSGAVLAGLL-GLPTELVAALGYCAV 345

Query: 360 VLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLL 397
               T      LF++  V     +LP    V+  A+L+
Sbjct: 346 FGTATNTLLAPLFISYEVF-GANILPYAIPVLAIAYLI 382


>UniRef50_A5TYL8 Chloride channel n=18 Tax=Actinobacteria (class) RepID=A5TYL8_MYCTA
          Length = 492

 Score = 88.3 bits (217), Expect = 4e-16,   Method: Composition-based stats.
 Identities = 87/436 (19%), Positives = 153/436 (35%), Gaps = 31/436 (7%)

Query: 5   RARTMLLLS-LPAVAIGIASSLILIVVMKIASVLQNLLWQRLPG------------TLGI 51
           R+   L    L  + IG+ + L  +V           L   L                  
Sbjct: 39  RSAGYLRKWFLLGITIGVIAGLGAVVFYLALKYTSEFLLGYLADYQIPTPVGEGGHRGST 98

Query: 52  AQDSPLWIIGVLTLTGIAVGLVIRFSQGHA---GPDPACEPLIGAP--VPPSALPGLIVA 106
               P  I  V T   +   L++      A   G D A E + G P  +   A+   +VA
Sbjct: 99  GFARPWAIPLVTTGGAVLSALIVAKLAPEATGHGTDEAIESVHGDPRAIRGRAVLVKMVA 158

Query: 107 LILGLAGGVSLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVA 165
             L +  G S G E P   ++      +  RL L   +      L     IGA+F  P+ 
Sbjct: 159 SALTIGSGGSGGREGPTAQISAGFCSLLTRRLNLSNEDGRTAVALGIGAGIGAIFAAPLG 218

Query: 166 AALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALT-TGLFFHPHFSLPIAHYGQMEMTDIL 224
            A     ++    +    + L   + +  A A+    L F P F    A Y   +   +L
Sbjct: 219 GA-ALGASIPYRDDFDYRNLLPGFIASGTAYAVLGAFLGFDPLFGYIDAEYRFEKAWPLL 277

Query: 225 SGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGL 284
              ++  IA A G +         A+  ++    ++    G +L  L  +  P  L  G 
Sbjct: 278 WFVVIGLIAAAVGYLYARVFHASVAITRRLPGGPVLKPAIGGLLVGLLGLPIPQILSSGY 337

Query: 285 DEMQQMVANQAFSTSDYFLLAVI---KLAALVVAAASGFRGGRIFPAVFVGVALGLMLHE 341
              Q         +   +++ V+   K+ A  ++  +G  GG   P + +G  +G  +  
Sbjct: 338 GWAQLAADRGTLLSIPLWIVIVLPIAKILATSLSIGTGGSGGLFGPGIVIGAFVGAAIWR 397

Query: 342 H-----VPAVP--AAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPA 394
                 +P VP    I V  A++     V+R     + M A +  + +++P   I +  A
Sbjct: 398 LGELTELPGVPHEPGIFVVVAMMACFGSVSRAPLAVMIMVAEMTGSFSVVPGAIIAVGIA 457

Query: 395 WLLLAGKPMMMVNRPK 410
            LLL+   + +    +
Sbjct: 458 ALLLSRTNVTIYETQR 473


>UniRef50_D0BLG2 Voltage-gated chloride channel protein n=1 Tax=Granulicatella
           elegans ATCC 700633 RepID=D0BLG2_9LACT
          Length = 521

 Score = 88.3 bits (217), Expect = 4e-16,   Method: Composition-based stats.
 Identities = 67/385 (17%), Positives = 140/385 (36%), Gaps = 27/385 (7%)

Query: 52  AQDSPLWIIGVLTLTGIAVGLVIRFSQGHAGP-DPACEPLIGAPVPP---SALPGLIVAL 107
            Q  P+WI+  + +  + +G +++      G   P  E  +   +     S      VA 
Sbjct: 60  PQWLPVWIVFSMIMA-VILGQIVKSEPDIKGSGIPQVELQLQGKMDMNWWSVCWKKFVAG 118

Query: 108 ILGLAGGVSLGPEHPIMTVNIALAVAIGARLLPRVNRMEWTILASAGTIGAL-FGTPVAA 166
            + +  G+ LG E P + +  ++A  +   L     +    I + AG   A  F  P+A 
Sbjct: 119 FISIGSGLLLGREGPSIQLGASVAQGVAEGLKSNRVQKNIFISSGAGAGLAAAFNAPIAG 178

Query: 167 ALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSG 226
            +   + ++ +            L AA      +   F    SL + +     M+     
Sbjct: 179 LMFVLEEVHHTFS---PLVALTTLTAAIVSNFVSLNIFGARPSLNLGNDQIFPMSHYGYV 235

Query: 227 AIVAAIAIAAGMVAVWCLPRLH----AMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFK 282
            ++  +    G V      +L      +   + N    +     I+ +   +  P  L  
Sbjct: 236 ILLGIVLGLFGWVYHHYTLQLPAIYGKLFPFIPNYYYCMVAFIAIIPL--GLWNPHVLGG 293

Query: 283 GLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEH 342
           G + + +++          FL  +++L   +++  +G  GG   P + +G  LGL+  E 
Sbjct: 294 GGEMILELLHENHTVQFLAFLF-ILRLFYSMLSYGTGLPGGIFLPILSLGALLGLVYAEV 352

Query: 343 VPA---VPAAITVS---CAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWL 396
           +     V  ++ VS    A+ G    + +    +L +   +V     L  L I  L A++
Sbjct: 353 LIQFFGVDPSLRVSFVFFAMAGYFSAIGKAPLTALLLVTEMVGGLNQLMPLGICTLTAYI 412

Query: 397 L-----LAGKPMMMVNRPKQQPPHD 416
           +     +     ++  R   + PH+
Sbjct: 413 VADYLKMGPIYEILAERLDSEHPHE 437


>UniRef50_UPI0001B54CF5 hypothetical protein StreC_17202 n=1 Tax=Streptomyces sp. C
           RepID=UPI0001B54CF5
          Length = 449

 Score = 88.3 bits (217), Expect = 5e-16,   Method: Composition-based stats.
 Identities = 89/412 (21%), Positives = 158/412 (38%), Gaps = 22/412 (5%)

Query: 8   TMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTG 67
           +   + L    +GI  SL+    +     LQ LLW+ LP +LG       W + +L + G
Sbjct: 35  SYRRILLLCALVGIPVSLVCFWFLAGLHELQRLLWESLPHSLGWDGPPWWWPLPLLLVGG 94

Query: 68  IAVGLVIRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVN 127
           I VGLV+    G  G  PA    +G       LPG+++A    L  G  LGPE P++ + 
Sbjct: 95  IGVGLVVARLPGAGGHVPAAGLAVGGA-STKVLPGVVLAAAASLPFGAVLGPEAPLIALG 153

Query: 128 IALAVAIGARLLPRVNRMEW---TILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWD 184
              A+ +                 +  +A  I A+FG+P+ AA++  + + G     L  
Sbjct: 154 SGFALLLRDLGRGPATPQATALLGVAGAAAAIAAIFGSPLIAAVLLIEVV-GVGGPQLVA 212

Query: 185 RLFAPLMAAAAGALT-------TGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAG 237
            +   L+++  GAL        TGL              +++  D+    ++A +  A  
Sbjct: 213 VMLPALLSSGVGALVFTGFGRWTGLQTGGLTVKLPGPVPRLDAADVGWALLLAVVLAAVV 272

Query: 238 MVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVS-------LFKGLDEMQQM 290
             A+     + A + +   PV+   +     G+       V+          G   M  +
Sbjct: 273 REALGAGQVVAAFVAKG--PVVRTALCALGAGVCAAAYALVTDRSPADVASSGQALMATL 330

Query: 291 VANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAI 350
             +         +  ++             RGG IFPA+F+G A   +L   +P +    
Sbjct: 331 AGDPRAWGVGALVAVLLCKTVGYALCLGSMRGGPIFPALFLGAAA-GVLAAPLPGLGVVP 389

Query: 351 TVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKP 402
            V+  +      V R    S  MA ++V +  + P++ +  + A +     P
Sbjct: 390 AVAAGLAAAGASVLRLPVSSAVMAILLVGSPGMTPVVILAAVAALITTELLP 441


>UniRef50_Q11QF8 Chloride channel protein n=1 Tax=Cytophaga hutchinsonii ATCC 33406
           RepID=Q11QF8_CYTH3
          Length = 453

 Score = 88.3 bits (217), Expect = 5e-16,   Method: Composition-based stats.
 Identities = 60/409 (14%), Positives = 145/409 (35%), Gaps = 23/409 (5%)

Query: 2   LHPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIG 61
            H  A  ++ L + +V +G+A+ +     + +  +    L         I+  + L    
Sbjct: 17  FHRTAYQLIPLWVASVLVGVAAVMYARGFLYVEDLSTEFLHTYPEAIFAISPVAFLSSWF 76

Query: 62  VLTLTGIAVGLVIRFSQGHAGPDPACEPLIGAPVPPSAL-----PGLIVALILGLAGGVS 116
           ++ +             G      A E    + +    L        +++ ++ LAGG +
Sbjct: 77  LVKVFAPMAAGS-----GIPQVMAAVELEGKSNLSRKLLNVKVSIVKVLSSLVMLAGGGA 131

Query: 117 LGPEHPIMTVNIALAVAIGARLL---PRVNRMEWTILASAGTIGALFGTPVAAALIFSQT 173
           +G E P + ++ ++   +   L     + +     +  +A  + A F TP+   +   + 
Sbjct: 132 IGREGPTIQISASIFSFMHHALPKQWEKFSAQLMVLTGAASGLAAAFNTPLGGIVFAIEE 191

Query: 174 LNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIA 233
           L           LF  ++      +T      P+  L          + IL     AA+A
Sbjct: 192 LTRIQFSKFRTTLFVAVI---ISGMTAQAMLGPYLYLGFPKVQVAGYSYILWVIAAAALA 248

Query: 234 IAAGMVAVWCLPRLHAMMHQMK---NPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQM 290
              G +    +  +H     +K     + ++ I       +        +  G + M+ +
Sbjct: 249 GFMGGMFGSLILVIHRWKKTIKTTGKHIAIVLIFALSFASIYYFFNRSVIGAGKEVMEDL 308

Query: 291 VANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEH--VPAVPA 348
           +       S   +L+  +    +++  SG  GG   P++  G  +G  +     +P+   
Sbjct: 309 LFISNKDVSPSLVLS--RFFGPILSFGSGGAGGIFAPSLCAGSTIGAFIAYVADIPSEFT 366

Query: 349 AITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLL 397
            + +   ++G +  VT   + S  +   +    +++  L +  + A+L+
Sbjct: 367 NLLILAGMVGFLTGVTHSPFTSAILVLEMTDRHSVIFYLMLAGMFAYLV 415


>UniRef50_B9Z495 Chloride channel core protein n=1 Tax=Lutiella nitroferrum 2002
           RepID=B9Z495_9NEIS
          Length = 554

 Score = 87.9 bits (216), Expect = 6e-16,   Method: Composition-based stats.
 Identities = 74/372 (19%), Positives = 129/372 (34%), Gaps = 11/372 (2%)

Query: 20  GIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQD-SPLWIIGVLTLTGIAVGLVIRFSQ 78
           G   +L       +       L+    G + +A   SP   +    + GIA G +++   
Sbjct: 22  GCLGALATHGFRLLLDGASRWLFGGDGGPVQVAGALSPGLRVLTPVIGGIAAGWILQQLP 81

Query: 79  G---HAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIG 135
               HA        L    +   A      +  + +  G S+G E  ++ +         
Sbjct: 82  QIRQHASDYMESIALGDGRLSLRATLLRAASSAMSIVSGSSIGREGSMIQLAALAGSLPA 141

Query: 136 ARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAA 194
           A   L   +R  W    +A  + A + TPVA AL   + +  S  +     L      A 
Sbjct: 142 ALARLGTAHRRLWLACGAAAGVSAAYNTPVAGALFVGEIILRSVTIETLGPLLLAAAGA- 200

Query: 195 AGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQM 254
              LT+   F       +        +  L  A++  +A          L R  A+  Q+
Sbjct: 201 --QLTSACLFADTAIYQLPPLTTQGDSSGLGFALLGIVAGLLTPGFQLLLHRSKAIFGQL 258

Query: 255 KNPV-LVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALV 313
             P+ L LG+GG  +G L ++  P     G   + Q++ + A+       +   KL A  
Sbjct: 259 PLPLWLKLGLGGAFVGGLSLLT-PHVWGNGYRTVGQLL-HTAWPLGLLLGVLTCKLLATA 316

Query: 314 VAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLVVTRDGWLSLFM 373
            A  SG  GG   P +FVG  LG +    +  +         ++  +         +  M
Sbjct: 317 AATGSGAVGGIFTPTLFVGAVLGAVCGHAITGLTGQPAGPLWVVAGMGAFLAAATQAPLM 376

Query: 374 AAVVVPNTTLLP 385
           A +++   T  P
Sbjct: 377 AIIMLLEMTRTP 388


>UniRef50_Q475N5 CBS:Cl-channel, voltage gated n=4 Tax=Cupriavidus
           RepID=Q475N5_RALEJ
          Length = 601

 Score = 87.9 bits (216), Expect = 6e-16,   Method: Composition-based stats.
 Identities = 81/404 (20%), Positives = 155/404 (38%), Gaps = 24/404 (5%)

Query: 11  LLSLPAVA-IGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPL-WIIGVLTLTGI 68
            ++L A   +GI +++   +  +       +++      + I     L W I V  + G 
Sbjct: 48  EVTLFAAIPVGILAAIATTLFKEALEGAGIVIFSSNADIVAIFAALALAWRIVVPAVGGA 107

Query: 69  AVGLVIRFSQGHAGP-----DPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPI 123
             GL+++ +   AG                 +P        ++    +  G S+G E  +
Sbjct: 108 VAGLLLQAANRLAGSGGATDYMEAVANGTGRLPVRVTLLRSLSSFCSIVSGASVGKEGAM 167

Query: 124 MTVNIALAVA-----IGARLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSS 178
           + +            IG        R   T   +A  +  ++ TP++AA+  ++ + G+ 
Sbjct: 168 IQLAALCGALFPSTRIGQPHGASNMRRMLTACGAAAGLATVYHTPLSAAVFVAEVVFGAL 227

Query: 179 EVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQ-MEMTDILSGAIVAAIAIAAG 237
            V    RL    +A+ AGA+ +          P  H    +    +L+ A +   A   G
Sbjct: 228 AV---QRLMPLFLASVAGAMVSQWHGGLQPLYPGLHIAADVRPQLMLAAAALGVAAGIVG 284

Query: 238 MVAVWCLPRLHAMMHQMKN-PVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAF 296
            + +           Q+   PV  L +GG ++G L +   P  +  G   +Q ++  Q  
Sbjct: 285 ALFLRAASIARGRFAQVPGGPVARLALGGALVGALAMAV-PEVVGNGFSTIQTILQEQPL 343

Query: 297 STSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFV----GVALGLMLHEHVPAVPAAITV 352
           + S   L+ + KLAA V++  SG  GG   P++FV    G  L L +   VP  PA+  +
Sbjct: 344 TVSVG-LVLLAKLAATVISMGSGAVGGVFTPSLFVGAALGQLLALAMQAFVPGAPASPVL 402

Query: 353 SCA-ILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAW 395
               +   +   ++   +S+ M   +     LL    I  + A+
Sbjct: 403 PLVGMSAFLAATSQAPLMSVLMVFEMTLAPALLLPTMIGAVAAY 446


>UniRef50_C2HCF1 Chloride carrier/channel (ClC) family transporter n=34
           Tax=Enterococcus RepID=C2HCF1_ENTFC
          Length = 446

 Score = 87.9 bits (216), Expect = 6e-16,   Method: Composition-based stats.
 Identities = 68/376 (18%), Positives = 126/376 (33%), Gaps = 17/376 (4%)

Query: 25  LILIVVMKI-ASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRFSQGHA-- 81
           L++  ++ +    L       L     I    P W++ +L ++G     +  +  G +  
Sbjct: 43  LVITAILGVFMGSLSAFFLNSLTFVTDIRIAHP-WLLYLLPVSGALFAYLYAYHGGLSSR 101

Query: 82  GPDPACEPLIGAP--VPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARL- 138
           G +   +   G    +P   +P  +   I     G S+G E   + +  ALA  I     
Sbjct: 102 GNNLVIDQGNGGEENIPLRLIPLTLFGTITTHLFGGSVGREGTAVQMGGALADNIARLFR 161

Query: 139 LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGAL 198
           L +  R    I   +    ++FGTP+A  L   + L  +      + +F    AA     
Sbjct: 162 LDKAEREILIISGISAGFSSVFGTPLAGTLFGLEVL--AIGKVRTEAIFPSFFAALFANF 219

Query: 199 TTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLH-AMMHQMKNP 257
            T  +   H    +    +  M       +        G V    +  L       + +P
Sbjct: 220 MTESYGVSHLHYQMGVIPEWSMLLFFKVFVAGIAFGLIGWVFSRSIVFLKARYAQWIPHP 279

Query: 258 VLVLGIGGFILGILGVIGGPVS-LFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAA 316
           V    IGG ++    +I      L   L  +Q+    QA +        + KL   V++ 
Sbjct: 280 VWRNTIGGAVVVAAALILQTQRYLGLSLPLLQESFNGQAHAYDF-----IGKLFFTVLSL 334

Query: 317 ASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLVVTRDGWLSLFMAAV 376
            +G++GG + P    G  LG  L   +      +     I G+    T        M   
Sbjct: 335 GAGYQGGEVTPLFETGATLGAALAPLLHVSVPFLAGLGFI-GVFSGATNTPIACFVMGIE 393

Query: 377 VVPNTTLLPLLCIVML 392
           +  +   +    I ++
Sbjct: 394 LFGSQAAVYFFMICLI 409


>UniRef50_Q03KD5 Chloride channel protein EriC n=13 Tax=Firmicutes
           RepID=Q03KD5_STRTD
          Length = 408

 Score = 87.9 bits (216), Expect = 7e-16,   Method: Composition-based stats.
 Identities = 78/396 (19%), Positives = 148/396 (37%), Gaps = 23/396 (5%)

Query: 7   RTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLT 66
             +++LSL A+ +G+   LI  V  ++   L       L            +++  L L 
Sbjct: 15  LHLVMLSLYAILLGVLVGLIDAVFGRVLIGLSEFRDHHL-----------FYLVPALPLA 63

Query: 67  GIAVGLVIRFSQGHAGPDPACEPLIG----APVPPSALPGLIVALILGLAGGVSLGPEHP 122
           G+ +  + +   G           +G      VP   +P + V   L    G S G E  
Sbjct: 64  GLLIVYLYQKFAGKTAQGMGLIFKVGHNEEDQVPLRLIPLVTVTTWLTHLFGGSAGREGV 123

Query: 123 IMTVNIALAVAIGARLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPL 182
            + +   ++ A             +  +  A   G LF TP+AA     + L  +     
Sbjct: 124 AVQLGATVSHAFSRYFKLPNASCIFLTMGMAAGFGGLFQTPIAATFFALEVL--TLGQLS 181

Query: 183 WDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVW 242
              L   L+A+   + T+ L     FS  ++    +++   +  A++      AG +  +
Sbjct: 182 LPILVPTLIASFMASTTSHLLGLEKFSHFVSKSLTIDLETFMKLALLGLAFGLAGNLFAY 241

Query: 243 CLP-RLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDY 301
            L      +   + NP   + +GG +L  L ++      + GL     ++A      + Y
Sbjct: 242 LLSLAKKKVASLLPNPYYRVLLGGVVLTCL-LLILCKGRYTGLGT--NLIALSVDGGTIY 298

Query: 302 FLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVL 361
            L  + KL   V   + GF+GG + P   +G +LG +L   +  +P ++      L +  
Sbjct: 299 PLDWLFKLLLTVFTLSLGFQGGEVTPLFAIGASLGAVLAPIL-GLPISLVAGLGYLSVFG 357

Query: 362 VVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLL 397
             T      +F+   V      +P   IVM  A+++
Sbjct: 358 SSTNTLLAPIFIGIEVFGPANAIPY-AIVMAFAYII 392


>UniRef50_Q1JHR4 Chloride channel protein n=25 Tax=Firmicutes RepID=Q1JHR4_STRPD
          Length = 424

 Score = 87.9 bits (216), Expect = 7e-16,   Method: Composition-based stats.
 Identities = 54/305 (17%), Positives = 111/305 (36%), Gaps = 18/305 (5%)

Query: 106 ALILGLAGGVSLGPEHPIMTVNIALAVAIGARLLPRVNRMEWTILASAGTIGALFGTPVA 165
           +  +    G S G E   + +   ++      +  +       I+  A     LF TP+A
Sbjct: 110 STWVTHLFGASAGREGVAVQIGATISHYCRRFVTSQEAARHLLIMGMAAGFAGLFQTPIA 169

Query: 166 AALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILS 225
           A +   + L        +  L   L+AA   + T+       F++ +     +    ++ 
Sbjct: 170 AVVFALEVL--LVGTLRYCALLPSLVAACVASWTSHSLGLEKFTIVLEETLTITPLTLVK 227

Query: 226 GAIVAAIAIAAGMVAVWCLPRLHA-MMHQMKNPVLVLGIGGFILGILGVIGG-PVSLFKG 283
              +  I    G      L      +  ++ NP L +   G +L I  +IG        G
Sbjct: 228 LIGLGLIFGLVGNSFACLLGWFKPYLSQKLPNPYLRIAFIGVLLSICLMIGHVGRYSGLG 287

Query: 284 LDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHV 343
              +    + Q   T D+ L    K+   V++ ++GF+GG + P   +G +LG++L  ++
Sbjct: 288 THLIAAAFSGQTILTYDWLL----KMIVTVISLSAGFQGGEVTPLFAIGASLGIVLAPYL 343

Query: 344 PAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPM 403
             +P  +  +   + +        W  +F+   V      L         A+ + +    
Sbjct: 344 -GLPVLLVAALGYVTVFGSAINTFWAPIFIGIEVFGPENAL---------AYFVTSAAAY 393

Query: 404 MMVNR 408
           M+ +R
Sbjct: 394 MVSHR 398


>UniRef50_B1LX30 Chloride channel core n=18 Tax=Alphaproteobacteria
           RepID=B1LX30_METRJ
          Length = 459

 Score = 87.5 bits (215), Expect = 8e-16,   Method: Composition-based stats.
 Identities = 69/310 (22%), Positives = 122/310 (39%), Gaps = 23/310 (7%)

Query: 95  VPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARLLPRVNRMEWTILASAG 154
           + P    G ++ L LGL  G S G E P + V  A+  A G     R+      +   A 
Sbjct: 128 ISPRVAFGKVLVLFLGLFCGASAGREGPTVQVGAAIMAAFGRLTPERL--PGLLLAGGAA 185

Query: 155 TIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAH 214
            + A F TP+A  +   + L  + E      + A ++AA   +L   L  + +F      
Sbjct: 186 GVAAAFNTPLAGIVFGIEELGRAYEARSSGLIVAGIVAAGLTSL-GLLGNYTYFGTT--- 241

Query: 215 YGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQM----------KNPVLVLGIG 264
               +    L+   +  +    G +A     RL  +  +           K PV+     
Sbjct: 242 ----DAALPLAAGWIVPLVAVVGGLAGGLFSRLVILFARGLPGAAGRAIRKRPVIFAAAC 297

Query: 265 GFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGR 324
           G  + + G+  G  +   G +E + ++   A +   Y   A +K AA V+++ SG  GG 
Sbjct: 298 GLCVALCGLASGGAAYGTGYEEAKAILHGDAAAGWTY---APLKFAATVLSSISGIPGGL 354

Query: 325 IFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLL 384
             P++ VG  LG  +H  +P +P    V   ++  +  V +    S  +   +  N  ++
Sbjct: 355 FAPSLAVGAGLGGTVHGLLPGMPVGAVVLIGMVAYLTGVLQAPITSFVIVTEMTQNHAMV 414

Query: 385 PLLCIVMLPA 394
             L +  L A
Sbjct: 415 IPLMVAALLA 424


>UniRef50_C0YZT6 Voltage-gated chloride channel family protein n=7 Tax=Lactobacillus
           reuteri RepID=C0YZT6_LACRE
          Length = 393

 Score = 87.5 bits (215), Expect = 8e-16,   Method: Composition-based stats.
 Identities = 75/387 (19%), Positives = 137/387 (35%), Gaps = 16/387 (4%)

Query: 10  LLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIA 69
           L + + AV   +   ++    + + + + +L+W +    L  A  S  +   V    G  
Sbjct: 6   LKIGIYAVVWSLIIGMLTAAYLNLVNWVIDLVWHQY---LDPAVSSKWYPFLVCIPLGFL 62

Query: 70  VGLVIRFSQGHAGPDPACEPLI--GAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVN 127
           +G +      +          +     +         +  +L L  G S+GPE     + 
Sbjct: 63  IGFLNERWGNYPLTIEQVLTQVRLKGQLNYHNWWKSFILGLLALGAGGSIGPEASTTVLT 122

Query: 128 IALAVAIGARLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLF 187
            ++   +G R+    +  +   L      G +    +A A  FSQ     S+        
Sbjct: 123 SSMINWLGDRMRWATSMRQKVSLW----YGKMQTQDLARAPRFSQLFKNKSQRVFVISGL 178

Query: 188 APLMAAAAGALTTGLFFHPHFSLPIAHYG-QMEMTDILSGAIVAAIAIAAGMVAVWCLPR 246
             +     GA      F       I H     E  ++L+      I IA G + V     
Sbjct: 179 VGI--GIVGAAIVFKLFPEEGVFGIHHRIINWEWINLLTSIPTIIIGIAFGWLFVHLENW 236

Query: 247 LHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQ-AFSTSDYFLLA 305
              +++   + +   GI G IL I  +I   + LF G   +          S     ++A
Sbjct: 237 AALIINAKISKIWQGGIFGLILAISSLITSDI-LFSGEFRIVPFTHEAFNHSIIFLLVVA 295

Query: 306 VIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLVVTR 365
           ++K     +  A G+RGG IFPA+F  VA+G      +P     I     I   +  +  
Sbjct: 296 LVKAVMSNLGFAMGWRGGTIFPAIFSSVAVGTACAMMLPGD-VRINAIVVIAASLTFILE 354

Query: 366 DGWLSLFMAAVVVPNTTLLPLLCIVML 392
              L++    ++VP   L P++ +V  
Sbjct: 355 KPLLTIIPLLLLVP-IELAPVIIVVAF 380


Searching..................................................done


Results from round 3


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value
Sequences used in model and found again:

UniRef50_Q64C69 Chloride channel n=1 Tax=uncultured archaeon GZf...   277   4e-73
UniRef50_D1JC90 Probable voltage gated chloride channel n=2 Tax=...   259   2e-67
UniRef50_A0LDC4 Cl-channel, voltage-gated family protein n=1 Tax...   258   2e-67
UniRef50_Q3A443 Chloride channel protein EriC n=2 Tax=Desulfurom...   257   5e-67
UniRef50_C9R8B5 Cl-channel voltage-gated family protein n=2 Tax=...   253   7e-66
UniRef50_A6DFZ2 Chloride channel family protein n=1 Tax=Lentisph...   250   7e-65
UniRef50_A9A065 Chloride channel core n=1 Tax=Desulfococcus oleo...   250   9e-65
UniRef50_C3WBQ0 Chloride channel protein n=1 Tax=Fusobacterium m...   249   2e-64
UniRef50_A5N0V4 ClcA n=2 Tax=Clostridium kluyveri RepID=A5N0V4_C...   249   2e-64
UniRef50_C7NEM7 Chloride channel core n=3 Tax=Leptotrichia RepID...   248   4e-64
UniRef50_A8SIK8 Putative uncharacterized protein n=1 Tax=Parvimo...   246   1e-63
UniRef50_Q316N5 CBS n=1 Tax=Desulfovibrio desulfuricans subsp. d...   246   1e-63
UniRef50_C5EV85 Chloride ion channel protein n=6 Tax=Clostridial...   245   2e-63
UniRef50_C6JKX7 Chloride channel protein n=5 Tax=Fusobacterium R...   243   9e-63
UniRef50_C9LB15 Voltage-gated chloride channel family protein n=...   242   2e-62
UniRef50_Q189E6 Chloride ion channel protein n=10 Tax=Bacteria R...   241   5e-62
UniRef50_Q39PZ5 Cl-channel, voltage gated n=4 Tax=Desulfuromonad...   240   6e-62
UniRef50_B5YZU3 Putative ion-transport protein yfeO n=97 Tax=Ent...   240   1e-61
UniRef50_B9XDX3 Chloride channel core n=1 Tax=bacterium Ellin514...   238   2e-61
UniRef50_A3CW01 Cl-channel, voltage-gated family protein n=3 Tax...   238   2e-61
UniRef50_Q0TP43 Voltage-gated chloride channel family protein n=...   238   4e-61
UniRef50_A4GJ08 Putative CBS:IMP dehydrogenase/GMP reductase:vol...   238   4e-61
UniRef50_B1C8T2 Putative uncharacterized protein n=2 Tax=Clostri...   237   5e-61
UniRef50_C5VU16 Voltage gated chloride channel family protein n=...   237   5e-61
UniRef50_Q6AIP2 Related to chloride channel protein n=1 Tax=Desu...   237   9e-61
UniRef50_Q892T8 Chloride channel protein n=1 Tax=Clostridium tet...   236   1e-60
UniRef50_D2BKV3 Chloride channel protein n=4 Tax=Lactococcus lac...   236   1e-60
UniRef50_B4CXW5 Chloride channel core n=1 Tax=Chthoniobacter fla...   235   2e-60
UniRef50_D0MHJ3 Chloride channel core n=1 Tax=Rhodothermus marin...   235   3e-60
UniRef50_C1F0W1 Chloride transporter, ClC family n=1 Tax=Acidoba...   235   3e-60
UniRef50_UPI000196B5DC hypothetical protein CATMIT_00127 n=1 Tax...   235   3e-60
UniRef50_D1AKC6 Chloride channel core n=2 Tax=Fusobacteriaceae R...   234   6e-60
UniRef50_Q04PD3 Chloride channel protein n=4 Tax=Leptospira RepI...   231   3e-59
UniRef50_C5NXG2 H(+)/Cl(-) exchange transporter ClcA n=1 Tax=Gem...   231   5e-59
UniRef50_Q8RXR2 Chloride channel protein CLC-f n=18 Tax=Magnolio...   230   6e-59
UniRef50_C7R845 Chloride channel core n=1 Tax=Kangiella koreensi...   229   2e-58
UniRef50_UPI0001BC5534 chloride channel protein n=3 Tax=Fusobact...   228   3e-58
UniRef50_Q8GX93 Chloride channel protein CLC-e n=7 Tax=Magnoliop...   227   6e-58
UniRef50_B2J2P8 Cl-channel, voltage-gated family protein n=3 Tax...   227   6e-58
UniRef50_A2ZX03 Putative uncharacterized protein n=2 Tax=Oryza s...   227   7e-58
UniRef50_C6C168 Chloride channel core n=1 Tax=Desulfovibrio sale...   225   2e-57
UniRef50_C6PDT2 Chloride channel core n=1 Tax=Thermoanaerobacter...   225   2e-57
UniRef50_Q21MI5 Cl-channel, voltage gated n=1 Tax=Saccharophagus...   225   2e-57
UniRef50_A8UVV7 tRNA (Uracil-5-)-methyltransferase Gid n=3 Tax=A...   225   3e-57
UniRef50_D1RX40 Chloride channel protein n=1 Tax=Serratia odorif...   225   3e-57
UniRef50_Q3AQR7 Chloride channel, putative n=12 Tax=Chlorobiacea...   225   4e-57
UniRef50_Q2JA24 Cl-channel, voltage gated n=4 Tax=Actinomycetale...   224   4e-57
UniRef50_A8TQW2 Cl-channel, voltage-gated family protein n=1 Tax...   224   4e-57
UniRef50_C8WVL6 Cl-channel voltage-gated family protein n=1 Tax=...   224   4e-57
UniRef50_C2D6G8 CPA2 family monovalent cation:proton (H+) antipo...   224   5e-57
UniRef50_A5TVM5 CIC chloride ion channel family chloride (Cl-):p...   223   8e-57
UniRef50_A0B965 Cl-channel, voltage-gated family protein n=3 Tax...   223   8e-57
UniRef50_Q03UF5 Chloride channel protein EriC n=4 Tax=Leuconosto...   223   9e-57
UniRef50_D1AXX8 Chloride channel core n=1 Tax=Streptobacillus mo...   223   1e-56
UniRef50_C5BP50 Chloride transporter, ClC family n=1 Tax=Teredin...   222   2e-56
UniRef50_A7BCR6 Putative uncharacterized protein n=1 Tax=Actinom...   221   3e-56
UniRef50_A6LXJ9 Chloride channel, core n=2 Tax=Clostridiales Rep...   221   3e-56
UniRef50_C9KMS0 Voltage-gated chloride channel family protein n=...   221   3e-56
UniRef50_UPI0001C418FE voltage-gated chloride channel protein n=...   221   3e-56
UniRef50_B0NZ23 Putative uncharacterized protein n=1 Tax=Clostri...   221   4e-56
UniRef50_Q0TQI9 Voltage-gated chloride channel family protein n=...   220   8e-56
UniRef50_A0NVL9 Cl-channel, voltage gated n=2 Tax=Alphaproteobac...   220   1e-55
UniRef50_Q12WA6 Voltage-gated ClC-type chloride channel n=5 Tax=...   220   1e-55
UniRef50_A5UNZ8 Voltage gated chloride channel protein/cation tr...   219   1e-55
UniRef50_A2BJY0 Voltage-gated chloride channel protein n=1 Tax=H...   219   2e-55
UniRef50_B1ZT36 Chloride channel core n=1 Tax=Opitutus terrae PB...   218   4e-55
UniRef50_B0CCE6 Cl-channel, voltage gated n=3 Tax=Cyanobacteria ...   217   5e-55
UniRef50_Q6SGK9 Voltage-gated chloride channel n=4 Tax=Bacteria ...   217   7e-55
UniRef50_Q14FN1 Voltage-gated ClC-type chloride channel clcA n=9...   217   7e-55
UniRef50_Q73KN8 Voltage-gated chloride channel n=2 Tax=Treponema...   216   8e-55
UniRef50_C0QAG4 EriC1 n=1 Tax=Desulfobacterium autotrophicum HRM...   216   1e-54
UniRef50_Q1K0X2 Cl-channel, voltage gated n=1 Tax=Desulfuromonas...   216   1e-54
UniRef50_Q1N3I5 Chloride channel, putative n=1 Tax=Bermanella ma...   216   1e-54
UniRef50_Q8DIV5 Tlr1476 protein n=1 Tax=Thermosynechococcus elon...   216   1e-54
UniRef50_D0LKI3 Cl-channel voltage-gated family protein n=1 Tax=...   215   2e-54
UniRef50_Q0BP43 CLC family chloride ion channel antiporter n=25 ...   215   3e-54
UniRef50_A0LKT1 Cl-channel, voltage-gated family protein n=1 Tax...   215   4e-54
UniRef50_C8X3C6 Cl-channel voltage-gated family protein n=1 Tax=...   214   4e-54
UniRef50_Q1MXQ9 Chloride channel protein EriC n=1 Tax=Bermanella...   214   5e-54
UniRef50_A4YDN2 Cl-channel, voltage-gated family protein n=19 Ta...   214   5e-54
UniRef50_C4ZAT1 Chloride channel protein EriC n=9 Tax=Bacteria R...   214   5e-54
UniRef50_B0SCJ7 Chloride channel protein n=2 Tax=Leptospira bifl...   213   7e-54
UniRef50_B2J0T5 Cl-channel, voltage-gated family protein n=10 Ta...   213   7e-54
UniRef50_C1SIP9 Chloride channel protein EriC n=1 Tax=Denitrovib...   213   8e-54
UniRef50_Q040F7 Chloride channel protein EriC n=29 Tax=Lactobaci...   213   9e-54
UniRef50_Q3MBC4 Cl-channel, voltage gated n=7 Tax=Bacteria RepID...   213   9e-54
UniRef50_D0BLG2 Voltage-gated chloride channel protein n=1 Tax=G...   213   1e-53
UniRef50_Q2S8Y1 Chloride channel protein EriC n=4 Tax=Gammaprote...   212   1e-53
UniRef50_C1F836 Chloride transporter, ClC family n=1 Tax=Acidoba...   212   2e-53
UniRef50_UPI0001C33F57 chloride channel protein n=2 Tax=Enteroba...   211   3e-53
UniRef50_D1U7C4 Chloride channel core n=2 Tax=Desulfovibrio RepI...   211   3e-53
UniRef50_A0LQV7 Cl-channel, voltage-gated family protein n=1 Tax...   211   4e-53
UniRef50_C8P2F0 Voltage-gated chloride channel family protein n=...   211   4e-53
UniRef50_D1XZY9 Chloride transporter, ClC family n=2 Tax=Prevote...   211   4e-53
UniRef50_B2TNJ2 Voltage-gated chloride channel n=19 Tax=Firmicut...   211   4e-53
UniRef50_Q020M6 Cl-channel, voltage-gated family protein n=2 Tax...   211   5e-53
UniRef50_B8G9L1 Chloride channel core n=1 Tax=Chloroflexus aggre...   211   5e-53
UniRef50_B6YRP1 Voltage-gated ClC-type chloride channel n=33 Tax...   210   8e-53
UniRef50_B0BZR2 Cl-channel, voltage gated, putative n=7 Tax=Cyan...   210   8e-53
UniRef50_B9L7R0 Voltage-gated chloride channel n=2 Tax=Nautiliac...   210   9e-53
UniRef50_C5PI54 Voltage gated chloride channel, putative n=7 Tax...   209   1e-52
UniRef50_B8HWS8 Chloride channel core n=6 Tax=Bacteria RepID=B8H...   209   1e-52
UniRef50_B3PL72 Voltage-gated chloride channel n=1 Tax=Cellvibri...   209   1e-52
UniRef50_P74477 Chloride channel protein n=12 Tax=Chroococcales ...   208   3e-52
UniRef50_A7HVW3 Chloride channel core n=1 Tax=Parvibaculum lavam...   208   3e-52
UniRef50_A6T4V9 H(+)/Cl(-) exchange transporter clcA n=13 Tax=Ga...   208   3e-52
UniRef50_C6W519 Chloride channel core n=1 Tax=Dyadobacter fermen...   208   4e-52
UniRef50_UPI000174564F putative voltage-gated ClC-type chloride ...   206   8e-52
UniRef50_A8ZW16 Chloride channel core n=1 Tax=Desulfococcus oleo...   206   1e-51
UniRef50_C7M702 Chloride channel core n=15 Tax=Bacteroidetes Rep...   206   1e-51
UniRef50_B9XGZ2 Chloride channel core n=3 Tax=Verrucomicrobia Re...   206   1e-51
UniRef50_A4WD06 Cl-channel, voltage-gated family protein n=5 Tax...   206   1e-51
UniRef50_B0MW79 Putative uncharacterized protein n=1 Tax=Alistip...   205   2e-51
UniRef50_C5VMQ7 Putative chloride channel n=1 Tax=Prevotella mel...   205   2e-51
UniRef50_A7FM08 H(+)/Cl(-) exchange transporter clcA n=12 Tax=En...   205   2e-51
UniRef50_Q1IME9 Cl-channel, voltage gated n=1 Tax=Candidatus Kor...   205   2e-51
UniRef50_C9LNJ2 Voltage-gated chloride channel family protein n=...   205   2e-51
UniRef50_Q2BHE2 Cl-channel, voltage gated n=1 Tax=Neptuniibacter...   205   3e-51
UniRef50_A6GII6 Putative chloride channel n=1 Tax=Plesiocystis p...   205   3e-51
UniRef50_D1W6U8 Chloride transporter, ClC family n=16 Tax=Bacter...   205   4e-51
UniRef50_A7HL32 Chloride channel core n=1 Tax=Fervidobacterium n...   204   4e-51
UniRef50_B7G9G8 Predicted protein n=1 Tax=Phaeodactylum tricornu...   204   5e-51
UniRef50_B2K549 H(+)/Cl(-) exchange transporter clcA n=40 Tax=Ga...   204   5e-51
UniRef50_B5JKG4 Chloride transporter, ClC family, putative n=1 T...   203   7e-51
UniRef50_C0W1S0 H(+)/Cl(-) exchange transporter n=1 Tax=Actinomy...   203   8e-51
UniRef50_C7PH71 Chloride channel core n=2 Tax=Bacteroidetes RepI...   203   9e-51
UniRef50_D0KW58 Cl-channel voltage-gated family protein n=1 Tax=...   203   9e-51
UniRef50_A8F4B4 Chloride channel core n=1 Tax=Thermotoga letting...   203   9e-51
UniRef50_C8NG64 Voltage-gated chloride channel family protein n=...   203   1e-50
UniRef50_UPI0001972FFA chloride channel protein EriC n=1 Tax=Clo...   203   1e-50
UniRef50_C0YIY4 Chloride carrier/channel (ClC) family transporte...   203   1e-50
UniRef50_A5VII6 Chloride channel, core n=18 Tax=Lactobacillaceae...   203   1e-50
UniRef50_B8FFG6 Chloride channel core n=2 Tax=Desulfobacteraceae...   203   1e-50
UniRef50_A6CC67 Putative chloride channel n=2 Tax=Planctomycetac...   202   2e-50
UniRef50_D2W1T3 Chloride channel ClC-3 n=1 Tax=Naegleria gruberi...   202   2e-50
UniRef50_Q701W5 Putative chloride channel protein n=1 Tax=uncult...   201   3e-50
UniRef50_C6BS05 Chloride channel core n=1 Tax=Desulfovibrio sale...   201   3e-50
UniRef50_D2RLN6 Cl-channel voltage-gated family protein n=1 Tax=...   201   3e-50
UniRef50_A5FBK4 Cl-channel, voltage-gated family protein n=4 Tax...   201   3e-50
UniRef50_C8WAP8 Chloride channel core n=2 Tax=Atopobium RepID=C8...   201   4e-50
UniRef50_C2KWR2 Chloride carrier/channel (ClC) family transporte...   201   5e-50
UniRef50_Q1ZH67 Chloride channel protein n=1 Tax=Psychromonas sp...   201   5e-50
UniRef50_C1MEP8 Voltage-gated chloride channel family protein n=...   200   7e-50
UniRef50_D1BPZ0 Chloride channel core n=3 Tax=Veillonella RepID=...   200   7e-50
UniRef50_B5XVU7 Chloride transporter, chloride channel (ClC) fam...   200   1e-49
UniRef50_Q1QSB4 Cl-channel, voltage gated n=1 Tax=Chromohalobact...   199   1e-49
UniRef50_C6HUP8 Putative Cl-channel, voltage gated n=1 Tax=Lepto...   199   2e-49
UniRef50_C1TRX3 Chloride channel protein EriC n=3 Tax=Synergista...   198   2e-49
UniRef50_Q15YG3 Cl-channel, voltage gated n=4 Tax=Alteromonadale...   198   4e-49
UniRef50_D1CB35 Chloride channel core n=6 Tax=Bacteria RepID=D1C...   197   7e-49
UniRef50_A6TUH7 Chloride channel, core n=2 Tax=Firmicutes RepID=...   197   7e-49
UniRef50_C8VN56 ClC chloride ion channel (Eurofung) n=10 Tax=Dik...   197   8e-49
UniRef50_Q1CYU1 Voltage-gated chloride channel n=2 Tax=Cystobact...   197   8e-49
UniRef50_B8FBB1 Chloride channel core n=1 Tax=Desulfatibacillum ...   196   1e-48
UniRef50_A0NVM0 Cl-channel, voltage gated n=4 Tax=Alphaproteobac...   196   1e-48
UniRef50_A6P174 Putative uncharacterized protein n=1 Tax=Bactero...   196   1e-48
UniRef50_A1AU45 Cl-channel, voltage-gated family protein n=5 Tax...   196   1e-48
UniRef50_A3HUV6 Putative transport related, membrane protein n=1...   196   2e-48
UniRef50_C0XMN8 CPA2 family monovalent cation:proton (H+) antipo...   195   2e-48
UniRef50_B0G1X5 Putative uncharacterized protein n=1 Tax=Dorea f...   195   2e-48
UniRef50_Q0EW01 Cl-channel, voltage gated n=1 Tax=Mariprofundus ...   195   3e-48
UniRef50_C5A3X3 Voltage-gated ClC-type chloride channel n=6 Tax=...   195   3e-48
UniRef50_B5CM99 Putative uncharacterized protein n=1 Tax=Ruminoc...   195   4e-48
UniRef50_C9RMG0 Cl-channel voltage-gated family protein n=1 Tax=...   194   5e-48
UniRef50_B6KKS4 Chloride channel protein, putative n=6 Tax=Alveo...   194   7e-48
UniRef50_B2KDW6 Chloride channel core n=1 Tax=Elusimicrobium min...   193   7e-48
UniRef50_A3EVY7 Putative Cl-channel, voltage gated n=2 Tax=Lepto...   193   9e-48
UniRef50_C7QDN8 Chloride channel core n=3 Tax=Actinomycetales Re...   193   1e-47
UniRef50_A4BAH0 Chloride channel protein EriC n=1 Tax=Reinekea b...   193   1e-47
UniRef50_B7FTG7 Predicted protein n=2 Tax=cellular organisms Rep...   193   1e-47
UniRef50_A5VHY5 Chloride channel, core n=9 Tax=Lactobacillus reu...   193   1e-47
UniRef50_B8DM62 Chloride channel core n=3 Tax=Desulfovibrionales...   192   2e-47
UniRef50_A9BT15 Chloride channel core n=9 Tax=Bacteria RepID=A9B...   192   2e-47
UniRef50_Q0ABK0 Cl-channel, voltage-gated family protein n=1 Tax...   192   2e-47
UniRef50_B2UN00 Chloride channel core n=1 Tax=Akkermansia mucini...   192   3e-47
UniRef50_B2UP88 Chloride channel core n=1 Tax=Akkermansia mucini...   191   3e-47
UniRef50_C7PDX9 Chloride channel core n=3 Tax=Bacteria RepID=C7P...   191   3e-47
UniRef50_A0YAR4 Chloride channel protein EriC n=1 Tax=marine gam...   191   3e-47
UniRef50_C6XZM8 Chloride channel core n=3 Tax=Sphingobacteriacea...   191   5e-47
UniRef50_P73745 Sll0855 protein n=1 Tax=Synechocystis sp. PCC 68...   191   5e-47
UniRef50_Q8XTT4 Putative chloride channel protein clcB-like n=62...   191   5e-47
UniRef50_C1SJ13 Chloride channel protein EriC n=1 Tax=Denitrovib...   191   6e-47
UniRef50_Q72EW7 Chloride channel family protein n=6 Tax=Desulfov...   190   6e-47
UniRef50_B0S0E6 Chloride channel protein n=2 Tax=Finegoldia magn...   190   8e-47
UniRef50_A9SXI1 Predicted protein n=1 Tax=Physcomitrella patens ...   189   1e-46
UniRef50_B5FF64 Chloride channel protein n=4 Tax=Bacteria RepID=...   189   2e-46
UniRef50_B9Z484 Chloride channel core protein n=1 Tax=Lutiella n...   189   2e-46
UniRef50_Q15SM8 Cl-channel, voltage gated n=1 Tax=Pseudoalteromo...   189   2e-46
UniRef50_B7G8L3 Predicted protein n=1 Tax=Phaeodactylum tricornu...   188   4e-46
UniRef50_B7CDF1 Putative uncharacterized protein n=1 Tax=Eubacte...   188   4e-46
UniRef50_B2V3B5 Voltage gated chloride channel family n=9 Tax=Cl...   188   4e-46
UniRef50_Q874K8 Voltage-gated chloride channel n=3 Tax=Filobasid...   188   4e-46
UniRef50_A3DHF3 Cl-channel, voltage gated n=5 Tax=Clostridium Re...   188   4e-46
UniRef50_B5YBN2 SycA n=1 Tax=Dictyoglomus thermophilum H-6-12 Re...   188   5e-46
UniRef50_Q31NT2 Chloride channel-like n=2 Tax=Synechococcus elon...   187   5e-46
UniRef50_Q0BQZ9 Chloride channel protein n=4 Tax=Acetobacteracea...   187   6e-46
UniRef50_D1PN62 Chloride transporter, chloride channel family n=...   187   6e-46
UniRef50_C7TB40 Chloride channel protein n=53 Tax=Lactobacillale...   187   6e-46
UniRef50_C5PV52 Chloride channel protein n=1 Tax=Sphingobacteriu...   187   7e-46
UniRef50_B9WL45 Voltage-gated chloride channel, putative n=6 Tax...   187   8e-46
UniRef50_C2E3Z4 CPA2 family monovalent cation:proton (H+) antipo...   187   8e-46
UniRef50_C4G1J1 Putative uncharacterized protein n=1 Tax=Abiotro...   187   9e-46
UniRef50_A6VUX7 Chloride channel core n=2 Tax=Marinomonas RepID=...   186   1e-45
UniRef50_C4Z1M2 Chloride channel protein, CIC family n=1 Tax=Eub...   186   1e-45
UniRef50_B2IWH4 Cl-channel, voltage-gated family protein n=2 Tax...   186   1e-45
UniRef50_B9WE28 Voltage-gated chloride channel, putative n=12 Ta...   186   1e-45
UniRef50_B9Z495 Chloride channel core protein n=1 Tax=Lutiella n...   186   1e-45
UniRef50_A7ZHP7 H(+)/Cl(-) exchange transporter clcA n=152 Tax=G...   186   1e-45
UniRef50_B2VDE2 Cl-channel, voltage gated n=4 Tax=Enterobacteria...   186   1e-45
UniRef50_Q1LQV6 Cl-channel, voltage gated n=66 Tax=Proteobacteri...   185   2e-45
UniRef50_B5EQW9 Chloride channel core n=2 Tax=Acidithiobacillus ...   185   2e-45
UniRef50_C0QQU7 Chloride channel protein n=1 Tax=Persephonella m...   185   3e-45
UniRef50_Q9VGH7 Chloride channel protein 2 n=19 Tax=Eumetazoa Re...   185   3e-45
UniRef50_C8X5N8 Cl-channel voltage-gated family protein n=1 Tax=...   185   3e-45
UniRef50_A3NY48 Chloride transporter, chloride channel (ClC) fam...   184   6e-45
UniRef50_Q3JE62 Cl-channel, voltage gated n=2 Tax=Nitrosococcus ...   184   6e-45
UniRef50_C1F1A6 Chloride transporter, ClC family n=1 Tax=Acidoba...   183   8e-45
UniRef50_A5DHQ2 Putative uncharacterized protein n=2 Tax=Pichia ...   183   8e-45
UniRef50_Q5KGF6 Putative uncharacterized protein n=1 Tax=Filobas...   183   8e-45
UniRef50_Q8KPV0 EriC n=4 Tax=Chroococcales RepID=Q8KPV0_SYNE7         183   9e-45
UniRef50_B8HL24 Chloride channel core n=1 Tax=Cyanothece sp. PCC...   183   9e-45
UniRef50_Q17804 Protein C07H4.2, confirmed by transcript evidenc...   183   9e-45
UniRef50_Q3M8F4 Cl-channel, voltage gated n=3 Tax=Cyanobacteria ...   183   1e-44
UniRef50_A4BVU6 Cl-channel, voltage gated n=1 Tax=Nitrococcus mo...   183   1e-44
UniRef50_Q2RI45 Cl-channel, voltage gated n=1 Tax=Moorella therm...   183   1e-44
UniRef50_D2QHH8 Cl-channel voltage-gated family protein n=1 Tax=...   183   1e-44
UniRef50_Q47VA1 Voltage-gated chloride channel n=2 Tax=Alteromon...   183   1e-44
UniRef50_B3DNT2 Chloride channel protein n=16 Tax=Bacteria RepID...   183   1e-44
UniRef50_A5G2G7 Cl-channel, voltage-gated family protein n=1 Tax...   183   2e-44
UniRef50_C6I4K1 Voltage-gated chloride channel protein n=31 Tax=...   183   2e-44
UniRef50_B2VX85 Chloride channel protein 3 n=17 Tax=Dikarya RepI...   182   2e-44
UniRef50_C3JN09 Cl-channel, voltage-gated family protein n=2 Tax...   182   2e-44
UniRef50_A3ZLX7 Chloride channel protein n=1 Tax=Blastopirellula...   182   2e-44
UniRef50_Q6BNC8 DEHA2E22814p n=2 Tax=Debaryomyces hansenii RepID...   182   2e-44
UniRef50_D1NB42 Cl-channel voltage-gated family protein n=1 Tax=...   182   2e-44
UniRef50_Q045T1 Chloride channel protein EriC n=19 Tax=Lactobaci...   181   4e-44
UniRef50_A5FTY4 CBS domain containing protein n=15 Tax=Bacteria ...   181   4e-44
UniRef50_Q3IHP9 Putative Voltage-gated ClC-type chloride channel...   181   4e-44
UniRef50_C4QGN7 Chloride channel protein, putative n=1 Tax=Schis...   181   4e-44
UniRef50_B9GHY7 Cl-channel clc-3 n=5 Tax=Magnoliophyta RepID=B9G...   181   4e-44
UniRef50_Q6C6J6 YALI0E09015p n=1 Tax=Yarrowia lipolytica RepID=Q...   181   6e-44
UniRef50_C7HUJ8 Chloride channel protein n=1 Tax=Anaerococcus va...   180   8e-44
UniRef50_A5VU61 Voltage gated chloride channel family protein n=...   180   9e-44
UniRef50_B1Z0X2 Chloride channel core n=79 Tax=Bacteria RepID=B1...   179   1e-43
UniRef50_A3ZQR8 Chloride channel protein-like n=1 Tax=Blastopire...   179   1e-43
UniRef50_Q0AMZ1 Cl-channel, voltage-gated family protein n=2 Tax...   179   2e-43
UniRef50_A6C318 Chloride channel protein n=2 Tax=Bacteria RepID=...   179   2e-43
UniRef50_C4LLM1 Putative ion channel protein n=1 Tax=Corynebacte...   179   2e-43
UniRef50_Q1GIU0 Cl-channel voltage gated n=37 Tax=Rhodobacterale...   179   2e-43

Sequences not found previously or not previously below threshold:

UniRef50_A5DRV5 Putative uncharacterized protein n=1 Tax=Loddero...   181   3e-44

>UniRef50_Q64C69 Chloride channel n=1 Tax=uncultured archaeon GZfos26B2
           RepID=Q64C69_9ARCH
          Length = 608

 Score =  277 bits (710), Expect = 4e-73,   Method: Composition-based stats.
 Identities = 70/459 (15%), Positives = 145/459 (31%), Gaps = 46/459 (10%)

Query: 2   LHPRARTMLLLSL-PAVAIGIASSLILIVVMKIASVLQNLLWQRLPG------------- 47
           L       +   +  ++ IG+A+    ++   + SV+ + +   +               
Sbjct: 16  LRKLNFEYIEHWVPYSILIGLAAGASAVIFYSLLSVVSHYVLGGIGHCYSTPTGCEQPLL 75

Query: 48  -------TLGIAQDSPLWIIGVLTLTGIAVGLV-IRFSQGHAGP----DPACEPLIGAPV 95
                     +A     +++ +  + G+  GL+  R++    G                +
Sbjct: 76  LVPSVIPPGSLADLHTWYLVAIPVIGGLVAGLITYRYAPEAVGEGTDAVIDSYHQQQGRI 135

Query: 96  PPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARLLPRVN-RMEWTILASAG 154
                    +A  + +  G S G E PI  +       +  +L    N R    +  +AG
Sbjct: 136 RGRIPIVKTIASAITIGTGGSAGREGPITQIGAGFGSYLADKLKLDDNGRRMMLLCGAAG 195

Query: 155 TIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAH 214
            IG++F  P+  AL     L        ++ L    +++          F          
Sbjct: 196 GIGSIFRAPLGGALFAISVLYKRDSE--FESLVPAFISSIIAYSVFCSVFGWGSLFTTPD 253

Query: 215 YGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVI 274
           Y      +++  AI+  +    G++ +     +  +  + K       + G +L  L V+
Sbjct: 254 YTFTHPAELVFDAILGILCGLVGILHIKTFHGIRDLFKKWKIKNYFKPMIGGLLLGLLVL 313

Query: 275 GGPV-------SLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFP 327
                          G + +Q  +  +  +     L  + K+ A      SG  GG   P
Sbjct: 314 SVHQSCGCGYCIFGGGYESVQSAIDGE-LAVEVLILFVLAKILATSFTLGSGGSGGVFAP 372

Query: 328 AVFVGVALGLMLHEHVPAVPAAI--------TVSCAILGIVLVVTRDGWLSLFMAAVVVP 379
            + VG  LG        A+   I         V   +  ++  V R    ++ + + +  
Sbjct: 373 TLAVGATLGGAFGIVAHALFPGIIGDMQSTSFVLIGMAALLAGVARVPIAAIVIVSELTG 432

Query: 380 NTTLLPLLCIVMLPAWLLLAGKPMMMVNRP-KQQPPHDN 417
           N  LLP L      A+L+     +     P +   P   
Sbjct: 433 NYNLLPPLMFASTIAYLVTTNWTIYEKQVPARVDSPAHR 471


>UniRef50_D1JC90 Probable voltage gated chloride channel n=2 Tax=uncultured archaeon
           RepID=D1JC90_9ARCH
          Length = 612

 Score =  259 bits (662), Expect = 2e-67,   Method: Composition-based stats.
 Identities = 69/454 (15%), Positives = 143/454 (31%), Gaps = 45/454 (9%)

Query: 7   RTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPG---------------TLGI 51
           + +    L ++ IGI +         +  ++ +     L G               +L  
Sbjct: 13  KYIQRWVLLSILIGIVAGFGAFAFYLLLQIMTDFFLGYLAGFQPTPPAGEQDVPYISLPT 72

Query: 52  AQDSPLWIIGVLTLTGIAVGLVIR-FSQGHAGP----DPACEPLIGAPVPPSALPGLIVA 106
           A      +  +  L G+ VGL+I  F+    G                +         +A
Sbjct: 73  APFHLWVLALMPALGGLIVGLIIYSFAPEAEGHGTDAIIDAFHNKKGVIRKRVPLIKAIA 132

Query: 107 LILGLAGGVSLGPEHPIMTVNIALAVAIGARLLPRVNR-MEWTILASAGTIGALFGTPVA 165
             + +  G S G E PI  +       +G +L           +  +A  IGA+F  P+ 
Sbjct: 133 SAITIGSGGSAGREGPIAQIGGGFGSFLGTKLKLGERETRMMMVCGAAAGIGAMFKAPLG 192

Query: 166 AALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLF--FHPHFSLPIAHYGQMEMTDI 223
           +AL  ++ L         + L   ++++               H       Y      ++
Sbjct: 193 SALFGTEVLYKRDFEM--ESLIPAIVSSVVAYAVFCSIPSIGWHPIFDTPPYTFTHPKEL 250

Query: 224 LSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVS---- 279
           +  A++     A G+  +       A   ++  P  +    G  L  + V+         
Sbjct: 251 IFFAVLGIACTALGIFYIKVFYATRAFFKRLAIPNHLKPAIGGALVGIFVLVIGYVEPQA 310

Query: 280 ----LFKGLDEMQQMVANQ---AFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVG 332
               L  G   +Q  +  +           ++A+ K+        SG  GG   P++ +G
Sbjct: 311 LDGILGMGYGTVQTAIDMELPLPELIELMIIVAIAKIFTTSFTIGSGGSGGVFAPSLVIG 370

Query: 333 VALGLMLHEHVPAVPAAITVSCAILGIVLV--------VTRDGWLSLFMAAVVVPNTTLL 384
             LG +           I     +   V+V          +    ++ M + +  + +LL
Sbjct: 371 AMLGGLFGGVSHFFFPEIITETTMSAFVVVGMAAFFAGAAKVPIAAILMISEMAGSYSLL 430

Query: 385 PLLCIVMLPAWLLLAGKPMMMVN-RPKQQPPHDN 417
             L +  + A+ L  G  +     + +++ P   
Sbjct: 431 VPLMLTSVVAYALSGGWTIYEKQVKTRKESPAHR 464


>UniRef50_A0LDC4 Cl-channel, voltage-gated family protein n=1 Tax=Magnetococcus sp.
           MC-1 RepID=A0LDC4_MAGSM
          Length = 582

 Score =  258 bits (661), Expect = 2e-67,   Method: Composition-based stats.
 Identities = 69/396 (17%), Positives = 144/396 (36%), Gaps = 18/396 (4%)

Query: 20  GIASSLILIVVMKIASVLQNLLWQRLPGTLG--IAQDSPLWIIGVLTLTGIAVGLVIRF- 76
           G+      I+   +    Q+L +      +   I+      +I    L G  VG ++ F 
Sbjct: 24  GVMVGYGAILFRTLIEGFQHLFFGSSAEDMVQVISGLQWWHVILAPMLGGAIVGPLVHFV 83

Query: 77  ----SQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAV 132
                        A   L GA +      G + A  + +  G S+G E P++ +   LA 
Sbjct: 84  FPGSRGHGVPEVMAAVALHGAKMNLKDGIGKMFACSISIGSGGSVGREGPVVHLGATLAS 143

Query: 133 AIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLM 191
             G +L +   +        +A  I A F  P+A  +   + +     +         ++
Sbjct: 144 WFGKQLNMSTKHMRTMVGCGAAAGIAASFNAPIAGVMFALEVILADYALA---TFSPIVL 200

Query: 192 AAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMM 251
           ++    +   L      +  + HY  +   +I +   +  +    G++ +  L +   ++
Sbjct: 201 SSVIATVIARLHLGDFPAFIVPHYTLVSAWEIPAYVGLGLVCGLTGILFMHTLFKAEDVI 260

Query: 252 HQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAA 311
            ++  P  +  + G +L  L  +  P  +  G D M + +  Q    +   L+ V K+ A
Sbjct: 261 GKIAVPRWIKPMFGGMLLGLIALQFPQIMGVGYDTMNKALLEQMIGPTMLMLVFV-KILA 319

Query: 312 LVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAI------TVSCAILGIVLVVTR 365
             +   SGF GG   P++F+G  +G     +  A+  AI           +  +   V  
Sbjct: 320 TSLTLGSGFSGGVFTPSLFLGAMVGGAFGTYAHALFPAISAGPGAYTLVGMGAMAAAVLG 379

Query: 366 DGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGK 401
               S+ +   +  +  ++  L +  + A LL+   
Sbjct: 380 APIASILILFELTGDYRIMLALMVASIVATLLINQV 415



 Score = 54.8 bits (131), Expect = 6e-06,   Method: Composition-based stats.
 Identities = 30/214 (14%), Positives = 64/214 (29%), Gaps = 27/214 (12%)

Query: 19  IGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRFSQ 78
           +G+   L  I+ M           + + G + + +             G+ +GL+     
Sbjct: 238 LGLVCGLTGILFMHTL-----FKAEDVIGKIAVPRW------IKPMFGGMLLGLIALQFP 286

Query: 79  GHAGPDPACE-----PLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVA 133
              G             +  P     +   I+A  L L  G S G   P + +   +  A
Sbjct: 287 QIMGVGYDTMNKALLEQMIGPTMLMLVFVKILATSLTLGSGFSGGVFTPSLFLGAMVGGA 346

Query: 134 IGARLLPRVNRM-----EWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFA 188
            G         +      +T++       A+ G P+A+ LI  +          +  + A
Sbjct: 347 FGTYAHALFPAISAGPGAYTLVGMGAMAAAVLGAPIASILILFELTGD------YRIMLA 400

Query: 189 PLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTD 222
            ++A+    L     +             +++  
Sbjct: 401 LMVASIVATLLINQVYRDSVYTKALRTKNIDLWS 434


>UniRef50_Q3A443 Chloride channel protein EriC n=2 Tax=Desulfuromonadales
           RepID=Q3A443_PELCD
          Length = 606

 Score =  257 bits (657), Expect = 5e-67,   Method: Composition-based stats.
 Identities = 66/433 (15%), Positives = 130/433 (30%), Gaps = 30/433 (6%)

Query: 11  LLSLPAVAIGIASSLILIVVMKIASVLQNLL---WQRLPG------------TLGIAQDS 55
              L +  +G+ +    +            +   W  L                 +    
Sbjct: 24  RFMLLSALVGLVAGAGALAFYFATDTATEWILVHWGGLHTPGHGNALQSGGVVNSLKMSH 83

Query: 56  PLWIIGVLTLTGIAVGLVI-RFSQGHAGPD----PACEPLIGAPVPPSALPGLIVALILG 110
             ++  +  L G+  G ++ RF+    G                +         +A +  
Sbjct: 84  RWFLFVIPVLGGLVSGWLVFRFAPEAEGHGTDAAIEAFHQKKGLIRGRVPVVKAIASVAT 143

Query: 111 LAGGVSLGPEHPIMTVNIALAVAIGARLLPR-VNRMEWTILASAGTIGALFGTPVAAALI 169
           ++ G S G E PI  +       +  RL     +R    +   AG +GA F  P+  AL 
Sbjct: 144 ISTGGSAGREGPIAQIGAGFGSFLADRLKLSVSDRRVLLLAGMAGGVGATFRAPLGGALF 203

Query: 170 FSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIV 229
             + L    E    + L   ++++       G        L    +      ++    ++
Sbjct: 204 AVEVLYQDPEFEH-EGLIPCIISSIVAYSLFGAVTGWSPLLATPAFRFEHPVELGFYLLL 262

Query: 230 AAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQ 289
                  G   V            +  P  +    G ++  +  +  P  L  G   +Q 
Sbjct: 263 GIACAILGTGYVKTFYYARDRFVALNMPTWLKPALGGLILGVMAMFVPQVLGSGYGWVQA 322

Query: 290 MVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAA 349
            +  +  +     LL + K+ A  +  +SG  GG   P++ +G  LG      V A+   
Sbjct: 323 ALYGK-MALWLMVLLGLGKIIATSLTISSGGSGGVFAPSLVIGAMLGGSFGAVVHALFPM 381

Query: 350 ITV------SCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPM 403
           +           + G    V      +L M + +  N  LL  L +V + A +      +
Sbjct: 382 LLAEPRTCVIIGMAGFFAGVANTPIATLIMVSELTGNYALLAPLMLVCVVAMVFFRRSSI 441

Query: 404 MMVNRP-KQQPPH 415
                  +   P 
Sbjct: 442 YQQQVTGRVDSPA 454


>UniRef50_C9R8B5 Cl-channel voltage-gated family protein n=2 Tax=cellular organisms
           RepID=C9R8B5_AMMDK
          Length = 598

 Score =  253 bits (648), Expect = 7e-66,   Method: Composition-based stats.
 Identities = 76/442 (17%), Positives = 139/442 (31%), Gaps = 29/442 (6%)

Query: 2   LHPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQD------- 54
           LH R     LL   A +IG  + +  IV  +   +   L      G              
Sbjct: 11  LHQRYLAKWLLI--AGSIGAVAGVGAIVFYEAIHLFTYLFLNLGAGFHPPEALGEGQPVV 68

Query: 55  ----SPLWIIGVLTLTGIAVGLVIRFSQ---GHAGPDPACEPLIG--APVPPSALPGLIV 105
                   I  V TL G+  GL++          G D A +        +        I+
Sbjct: 69  TEISRRWMIPVVTTLGGLLSGLIVFKFAPEAEGHGTDAAIDAFHHKEGIIRARVPLVKII 128

Query: 106 ALILGLAGGVSLGPEHPIMTVNIALAVAIGARLLPRVNRM-EWTILASAGTIGALFGTPV 164
           A  + +  G S G E P   +       +G  L                  IGA+F  P+
Sbjct: 129 ASAITIGSGGSAGREGPTAQIAAGFGSIMGQLLKLNTRDRCIALATGIGAGIGAIFKAPL 188

Query: 165 AAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLP-IAHYGQMEMTDI 223
             AL+ ++ L           L    +A+  G      +         ++     +   +
Sbjct: 189 GGALLSTEILYLEGFE--VQALVPSFIASLIGYTIFASYAGYMPVFGWMSQNIAFDPVTL 246

Query: 224 LSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKG 283
           L  A++  +    G++             ++  P  +    G +L  +  +  P  L  G
Sbjct: 247 LYYALLGVLCGLIGILYTKTFYATRNFFKKINLPKWLKPAAGGLLVGIMGLFLPQVLGMG 306

Query: 284 LDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHV 343
              +Q  + N+        LL   K+ A  +   SG  GG   P +F+G  +G  L + +
Sbjct: 307 YGWLQLGMLNKPLPLDIVVLLIFAKILATSLTIGSGGSGGVFAPGLFIGGMVGTALWQLL 366

Query: 344 PAV------PAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLL 397
             +           +   ++ +   V       +FM   +  + T+L    I +  A++L
Sbjct: 367 HGMVGHLPASPQPFIVVGMMALFGAVAHAPLAVMFMVGEMTGSYTMLVPAMIAVGIAYVL 426

Query: 398 LAGKPMMMVNRPKQ-QPPHDNV 418
           +    +     P     P   +
Sbjct: 427 VGNNTIYESQVPTPADSPAHRL 448


>UniRef50_A6DFZ2 Chloride channel family protein n=1 Tax=Lentisphaera araneosa
           HTCC2155 RepID=A6DFZ2_9BACT
          Length = 613

 Score =  250 bits (639), Expect = 7e-65,   Method: Composition-based stats.
 Identities = 80/450 (17%), Positives = 145/450 (32%), Gaps = 45/450 (10%)

Query: 10  LLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQR------------------------- 44
           L + + ++ +G+ + L+  +        + +++                           
Sbjct: 16  LKMVVLSITVGVITGLVASLFFLFLEWAKAIIFDGILGLKLASPPGEHIISDDNLIHIKT 75

Query: 45  -LPGTLGIAQDSPLWIIGVLTLT-GIAVGLVIRFSQGHA----GPDPACEPLIGAPVPPS 98
            L   +       L II V  L  G+A  LV RF+   A               A +  S
Sbjct: 76  TLYDRIFSNIPQSLLIILVPGLGCGLAAYLVRRFAPNAAYDGTSALVDTFHNKRAKMKLS 135

Query: 99  ALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARLLPR-VNRMEWTILASAGTIG 157
                 +A I+ LA G S G E P+  V       +  +L      R    +   AG +G
Sbjct: 136 TAFTKGIASIITLASGGSGGKEGPVAQVGAGCGSYLADKLKLSVKERRVLFLSGCAGGLG 195

Query: 158 ALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQ 217
           A+F  P+ AA+   + L         + +   ++A+     T  L F  H    +     
Sbjct: 196 AIFRAPLGAAITAVEVLYKEDFE--SEAIMPCVIASVTSYSTFMLTFGSHTIFNLGEVES 253

Query: 218 ME-MTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGG 276
            E    I S  ++A    A G   V           ++K P  +  + G +L  L  +  
Sbjct: 254 FEGFFHIPSYILLALTCSAIGAFYVKFYQFTKEFFIKLKIPTPIKPVVGGMLTGLLALIM 313

Query: 277 PVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALG 336
           P +L  G   +Q+++     +     L  ++K+ A  +   SG   G   P++F+G   G
Sbjct: 314 PYALGDGWGAIQEVMDGN-LTLGFIALAVIVKIVATSLTIGSGGSAGIFGPSLFIGAMTG 372

Query: 337 LMLHEHVPAVPA--------AITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLC 388
             L   +                V   +      V      S+ M   +     LL  L 
Sbjct: 373 GCLGSFLHMQFPDNPMVPSITAFVMVGMAAFFAGVANAPIASIIMVCEITGTYNLLAPLL 432

Query: 389 IVMLPAWLLLAGKPMMMVNRPKQ-QPPHDN 417
           +    + L  +   +       + + P   
Sbjct: 433 LTSAFSMLFNSKVSIFKPQVLNKFESPAHK 462


>UniRef50_A9A065 Chloride channel core n=1 Tax=Desulfococcus oleovorans Hxd3
           RepID=A9A065_DESOH
          Length = 669

 Score =  250 bits (638), Expect = 9e-65,   Method: Composition-based stats.
 Identities = 71/410 (17%), Positives = 147/410 (35%), Gaps = 16/410 (3%)

Query: 4   PRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTL-GIAQDSPLWIIGV 62
           P     L L L A+ +G+ S L  + +  +      L +      L  + Q S    +  
Sbjct: 8   PLTNRHLNLILLALVVGVCSGLGAVAIRLMIKYGTLLFFGVYGNFLESVTQVSVARRLAA 67

Query: 63  LTLTGIAVGLVIRFSQGHA-----GPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSL 117
             L G+ VG +I F    A             L    +         +A  + +  G S+
Sbjct: 68  PMLGGLIVGPLIYFLAKEAKGHGVPEVMLAVLLRDGRIRKRVAFVKALASAITIGSGGSV 127

Query: 118 GPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNG 176
           G E PI+ +  +L   I  R  L + +        +AG I A F  P+A AL   + + G
Sbjct: 128 GREGPIVQIGSSLGSTIAQRFNLEKRDTATLVACGAAGGIAAAFNAPIAGALFAVEIILG 187

Query: 177 SSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAA 236
              V     L   ++++    +          +  +  Y      +++   ++ A+A   
Sbjct: 188 DFGVA---ALSPIIISSVISTIVARGLEGNLVAFSVPPYALNTPWELIPYTVLGAVAGLV 244

Query: 237 GMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAF 296
            ++ +  L R+       + P  +    G +L  +  +  P     G D +   +   A+
Sbjct: 245 AVLFIVVLYRMEHAYDNWRFPEYLKPFTGGVLVAIICLAFPHMYGVGYDSINGALHG-AW 303

Query: 297 STSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPA-----AIT 351
                  +  +K+ A  +  ASG  GG   P++F+G ++G ++      +          
Sbjct: 304 PLWMLVAMVFMKIMATSITLASGGSGGVFAPSLFIGASVGGVVGTVTHQLFPQAATSGTY 363

Query: 352 VSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGK 401
               +  +V   T+    ++ +   +  +  ++P L    + + L+ +  
Sbjct: 364 ALVGMGAVVAATTQAPITAIIIIFELTQDYHIIPPLMFSCIISTLVASMV 413


>UniRef50_C3WBQ0 Chloride channel protein n=1 Tax=Fusobacterium mortiferum ATCC 9817
           RepID=C3WBQ0_FUSMR
          Length = 522

 Score =  249 bits (636), Expect = 2e-64,   Method: Composition-based stats.
 Identities = 58/424 (13%), Positives = 134/424 (31%), Gaps = 24/424 (5%)

Query: 11  LLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAV 70
            L L  + +G  +  I+ +     +   +     +  +L     +  +I     L G+ V
Sbjct: 19  KLYLLCIIVGALTGFIVSLYRWALNYANHFREFIVKNSLSEGTLTIFFIWISFILIGLIV 78

Query: 71  GLVIRFSQGHAGP-DPACEPLIGAPVPPSALP----GLIVALILGLAGGVSLGPEHPIMT 125
             + +     +G   P  + ++   +             +A ++ +  G+SLG E P + 
Sbjct: 79  DYISKKYPKISGSGIPQVKGILLRKLDYVNWLQELIAKFIAGLMSIGAGLSLGREGPSVQ 138

Query: 126 VNIALAVAIGARLLPRV-NRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWD 184
           +   +   I          +       S+  +   FG P++  +   + L+      L  
Sbjct: 139 LGSYIGFGITKIFKKDSIEKKYLVTSGSSAGLAGAFGAPLSGVMFALEELHKYISAKL-- 196

Query: 185 RLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDI---LSGAIVAAIAIAAGMVAV 241
            L    +A+ A        F    S  +       +      +   I+  +    G +  
Sbjct: 197 -LICTFLASIASDFVGRRMFGMETSFNLIANYPKNINPYYQFILYIILGIVIAFFGKLFT 255

Query: 242 WCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDY 301
             L ++     ++K    +         +L     P     G + +++M      +    
Sbjct: 256 LTLIKVQDKFKELKISRWIKISFVMSTSLLFCYFLPEVTGGGHELVEEMAGGNR-TIQLL 314

Query: 302 FLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHV------PAVPAAITVSCA 355
            ++ + KL    +  A+GF GG   P + +G  +G +    +              +   
Sbjct: 315 IIIFLAKLFFTALCYATGFAGGIFLPMLVLGAIIGKIYGLTLIKYLGVGLDFVPHFMVLG 374

Query: 356 ILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPM-----MMVNRPK 410
           + G  + V R       +   +  N   L  L  V + A+ +     +     ++  R  
Sbjct: 375 MAGYFVAVVRAPITGAVLILEMTGNFDHLLALVTVSVVAYYVTELLGLEPIYEILFKRMP 434

Query: 411 QQPP 414
           +  P
Sbjct: 435 KDTP 438


>UniRef50_A5N0V4 ClcA n=2 Tax=Clostridium kluyveri RepID=A5N0V4_CLOK5
          Length = 523

 Score =  249 bits (636), Expect = 2e-64,   Method: Composition-based stats.
 Identities = 66/415 (15%), Positives = 134/415 (32%), Gaps = 18/415 (4%)

Query: 10  LLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIA 69
           + L   ++ +GI +  I+++   +   L   + +     L      PLWII  + L  I 
Sbjct: 18  IRLVGESIIVGIITGFIIVLFRVVIEELGEKVGKIYEILLLKLYFLPLWIILFIILGYIL 77

Query: 70  VGLVIRFSQGHAGPDPACEPLIGAPVP---PSALPGLIVALILGLAGGVSLGPEHPIMTV 126
             +V +         P  +  +   +       +    V   L +  G+SLG E P + +
Sbjct: 78  GFMVKKDPMVGGSGIPQVKGAVLRKLEMKWFKVILNKFVGGSLAIGFGLSLGREGPSVQL 137

Query: 127 NIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDR 185
              +   +        +         ++  + A F  P+A A+   + ++ +        
Sbjct: 138 GACVGQGLSRIFKRVNIEEKYLITSGASAGLAAAFNAPLAGAIFALEEIHKNFSP---LI 194

Query: 186 LFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLP 245
           L +   AA +    TG F          H   + +       +   I    G++    L 
Sbjct: 195 LISAFSAALSADFITGGFLGLSPVFNFKHISAIPLNYYFYILLFGIIMGVTGVIFNIFLL 254

Query: 246 RLHAMMHQMKN-PVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLL 304
           +   +  + K  P     +   +  I+     P  L  G   +  +  N +F+     +L
Sbjct: 255 KSQHLYSKQKWIPKEFNPVFPLLTSIIFGFFLPQVLGGGNSLIMSLA-NTSFTIKFILVL 313

Query: 305 AVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHV------PAVPAAITVSCAILG 358
            ++K    ++   SG  GG   P + +G  +G      +              V   + G
Sbjct: 314 IIVKFLFTMLCYGSGTPGGIFLPVLTIGALIGYGYGSLLINILNINTNYINNFVILGMAG 373

Query: 359 IVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL---AGKPMMMVNRPK 410
               V R       +   +         L IV + A+L+      KP+      +
Sbjct: 374 YFTAVVRSPITGTILITEMTGGFNNFLPLSIVSIVAYLVADVLGSKPIYDSLLER 428


>UniRef50_C7NEM7 Chloride channel core n=3 Tax=Leptotrichia RepID=C7NEM7_LEPBD
          Length = 560

 Score =  248 bits (633), Expect = 4e-64,   Method: Composition-based stats.
 Identities = 66/411 (16%), Positives = 130/411 (31%), Gaps = 21/411 (5%)

Query: 7   RTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLT 66
           R  ++L      +GI S +I+     +   +          T  +     +  I V  L 
Sbjct: 19  RNNIVLIFLCFLVGIFSGIIVGTYTLLLKKMSIFREFF---TTNLELPKIIIGIIVFILM 75

Query: 67  GIAVGLVIRFSQGHAGP-DPACEPLIGAPVPPSA---LPGLIVALILGLAGGVSLGPEHP 122
           G+AV  ++      +G   P    L+   V       L    V  IL +  G+S+G E P
Sbjct: 76  GMAVQFMLSKYPLISGSGIPQVSGLLTKKVKFKWFGELVTKFVGGILAIGTGMSMGREGP 135

Query: 123 IMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVP 181
            + +   +   I        V         ++  I + F  P+A  +   + L+      
Sbjct: 136 SVHLGALVGSGIKEVTKRSEVEEKYLVTCGASAGISSTFNAPLAGVIFSLEELHKFFSPL 195

Query: 182 LWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAA---GM 238
           L   L   L+A+      + +    H S         ++   +   I     I     G 
Sbjct: 196 L---LICTLVASGTSNFISRMILGSHTSFQYNFMLPKDIPYYIFAIITVIFCIIITITGK 252

Query: 239 VAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFST 298
              + L  +     + K    V  +   I+     +        G + +++M   +    
Sbjct: 253 AFSYFLLLIQRQYKKWKLNKYVKMLLFMIIAYAIAVFFSDITGGGHELIEEMF-GKNVLL 311

Query: 299 SDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVP------AAITV 352
               ++ V+K    ++  A+G  GG   P + +G   G +  E +              +
Sbjct: 312 RTLIIILVLKFFYTMLCYATGAPGGIFLPMLVIGALTGKVYGEILNHYFSIPNEIIVHFM 371

Query: 353 SCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPM 403
              +      V R     + +   +  N + L +L IV    ++      M
Sbjct: 372 LLGMAAYFTAVVRAPITGITLILEMTGNFSYLYMLIIVCTITYIFTELLKM 422


>UniRef50_A8SIK8 Putative uncharacterized protein n=1 Tax=Parvimonas micra ATCC
           33270 RepID=A8SIK8_9FIRM
          Length = 510

 Score =  246 bits (629), Expect = 1e-63,   Method: Composition-based stats.
 Identities = 66/398 (16%), Positives = 141/398 (35%), Gaps = 18/398 (4%)

Query: 7   RTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLT 66
           +  L L    + +GIA+  +      I   ++      + G +     S  +I  ++ + 
Sbjct: 13  KEDLKLLFYGILVGIAAGGLSSFYRYIIHGIE-----GIIGGIVNISRSHFYIYPIIFIA 67

Query: 67  GIAVGLVIRFSQG-----HAGPDPACEPLIGAPV---PPSALPGLIVALILGLAGGVSLG 118
            I +  ++   +           P  E  I   +   P   L   I    L    G S+G
Sbjct: 68  LIFISFLVTKIKKMSRFCGGSGIPQVEAEIKGYINPNPVKVLLAKIFGGALTALAGFSVG 127

Query: 119 PEHPIMTVNIALAVAIGARLLPRVN-RMEWTILASAGTIGALFGTPVAAALIFSQTLNGS 177
            E P + +       +  +L              ++  + A F  PVA  L   + ++  
Sbjct: 128 REGPSIQIGAMSGKLVSRKLKKNKTVEKFLITCGASAGLAAAFNAPVAGILFAVEEVHRH 187

Query: 178 SEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAG 237
               L   L   + A     L + + +        +   ++ + +  +  + A +    G
Sbjct: 188 ISKKL---LVVCMAATITADLVSKILYGTETVFNFSMAEKLPLVNYWTLILFAVVLSVLG 244

Query: 238 MVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFS 297
           ++ ++ +     +   +        I  F+L I+ +I  P  L  G   M+++     F 
Sbjct: 245 VLYIFLMEFFMKIQDGLNLKKEFKLIPYFLLPIVILIFTPNLLGGGGFLMKEL-QTVDFP 303

Query: 298 TSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAIL 357
                LL ++KL   ++  +SG  GG  FP + +G  +G +  + +  +     +   + 
Sbjct: 304 IYMLILLFIVKLLFSIICFSSGVPGGIFFPILVLGATVGTIFGKIIDPIYINSFIILGMA 363

Query: 358 GIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAW 395
           G +  + R    S+ +   +  N + L  L IV L  +
Sbjct: 364 GYLTAIVRAPLTSIILIFEMTGNLSYLLPLSIVCLITY 401


>UniRef50_Q316N5 CBS n=1 Tax=Desulfovibrio desulfuricans subsp. desulfuricans str.
           G20 RepID=Q316N5_DESDG
          Length = 615

 Score =  246 bits (628), Expect = 1e-63,   Method: Composition-based stats.
 Identities = 68/405 (16%), Positives = 134/405 (33%), Gaps = 17/405 (4%)

Query: 8   TMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLW-IIGVLTLT 66
           + L + L AV +G+      ++   +   +Q L +      L      P W +I      
Sbjct: 47  SHLPMLLMAVLVGVLGGYGAVLFKFVIKGVQFLFYGNTADFLEFHDSVPYWAVIAAPAAG 106

Query: 67  GIAVGLVIRFS-----QGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEH 121
           G+AVG ++                    L    +        I A  + ++ G S+G E 
Sbjct: 107 GLAVGYLVSRFAREARGHGVPEVMEAIALHDGRIRKRVALVKIFASAISISSGGSVGREG 166

Query: 122 PIMTVNIALAVAIGARLLPRV-NRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEV 180
           PI+ +   +   +G  L      R       +A  I A F  PVA  L   + L G   +
Sbjct: 167 PIVQIGSGIGSTVGQMLKVGRPQRRTLVGCGAAAGIAATFNAPVAGVLFALELLLGDFGL 226

Query: 181 PLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVA 240
                    ++++      +  +F    +  +  Y    + +      +  +  A  ++ 
Sbjct: 227 A---AFSPVVLSSVVATTISRHYFGDFPAFVVPGYEVASLWEYGIYPFLGIVCGAVAVIF 283

Query: 241 VWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSD 300
           V  L R   +   ++ P  +    G       ++  P     G   +   + N       
Sbjct: 284 VTVLYRTEDLCEAVRLPDPLKACLGGAAVGCMLLWFPHVFGVGYGGINLALQNG-LGWQM 342

Query: 301 YFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAI------TVSC 354
             LL  +K+ A  V   SG  GG   P++F+G   G         +   I          
Sbjct: 343 MLLLVGVKIIATSVTIGSGGSGGVFAPSLFIGSMTGGFFGWAAGQLFPGITALPGAYALV 402

Query: 355 AILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLA 399
           A+ G+V   T     ++ +   +  +  ++  L +  + A +  +
Sbjct: 403 AMGGLVAGTTHAPITAILIIFELTGDYQIILPLMVTCILATVTAS 447


>UniRef50_C5EV85 Chloride ion channel protein n=6 Tax=Clostridiales
           RepID=C5EV85_9FIRM
          Length = 526

 Score =  245 bits (626), Expect = 2e-63,   Method: Composition-based stats.
 Identities = 69/396 (17%), Positives = 139/396 (35%), Gaps = 15/396 (3%)

Query: 12  LSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVG 71
           L L  VA+G  +  +++    +      LL   L          P+W + ++    +  G
Sbjct: 22  LILEGVAVGAIAGAVVVAFRYLIGYADTLLNAILDYGKANTWFIPVWFLILVAAAFVVAG 81

Query: 72  LVIRFSQGHAGPDPACEPLIGAPVP---PSALPGLIVALILGLAGGVSLGPEHPIMTVNI 128
           L+   S       P  E  I   +       L   +   IL L  G+SLG E P + +  
Sbjct: 82  LLKWESLISGSGIPQVEGEIIGEIDECWWRVLLAKLGGGILSLGCGLSLGREGPSIQLGA 141

Query: 129 ALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLF 187
             A          R          ++  + A F  P+A  L   + ++      L   L 
Sbjct: 142 MAAKGFSRLTKRVRTEEKLLITCGASAGLSAAFNAPIAGILFSLEEVHKHISPEL---LL 198

Query: 188 APLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRL 247
           + + A+      +   F             M +       ++  +  A G+V    L ++
Sbjct: 199 SSMAASITSDFVSRNVFGLKPVFTFTITHMMPLNTYGHVLLLGVLIGAMGVVYNTVLSKI 258

Query: 248 HAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVI 307
             +  ++   ++ + +  F+L  +        L  G   +++M A   F      LL V+
Sbjct: 259 QDLYERIPWRLVRV-LIPFLLAGVFGFLYRGVLGGGHALVEEMSAG-DFVLGSLCLLLVV 316

Query: 308 KLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAI------TVSCAILGIVL 361
           K    +V+  SG  GG   P + +G  +G + +     +  ++       +   + G   
Sbjct: 317 KFCFSMVSFGSGAPGGIFLPLLVLGAIIGSIYYRLAEPLSPSLSGLLVNFIILGMAGYFS 376

Query: 362 VVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLL 397
            + R     + + + +  + + L  L +V L A+L+
Sbjct: 377 AIVRAPITGIILISEMSGSFSHLLTLSMVSLAAYLV 412


>UniRef50_C6JKX7 Chloride channel protein n=5 Tax=Fusobacterium RepID=C6JKX7_FUSVA
          Length = 524

 Score =  243 bits (621), Expect = 9e-63,   Method: Composition-based stats.
 Identities = 58/428 (13%), Positives = 129/428 (30%), Gaps = 24/428 (5%)

Query: 11  LLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAV 70
            L +  + +GI + LI+ V         ++           +      +       G+ V
Sbjct: 20  KLYMLCLGVGIMTGLIVSVYRWGLGYANHIRESIFSHEDMESPMFLAMVWVGFIGIGLLV 79

Query: 71  GLVIRFSQGHAGP-DPACEPLIGAPVPPSALP----GLIVALILGLAGGVSLGPEHPIMT 125
            L+ +     +G   P  + +I   +             +  + G+  G+SLG E P + 
Sbjct: 80  DLIAKKYPKTSGSGIPQVKGIILRQLDYVKWFQELIAKFIGGLFGIGCGLSLGREGPSVQ 139

Query: 126 VNIALAVAIGARLLPRV-NRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWD 184
           +   +   +          +       ++  +   FG P+A  +   + L+         
Sbjct: 140 LGSYIGYGVTKIFKRDSVEKKYLVTSGASAGLAGAFGAPLAGVMFSLEELHKFIS---SK 196

Query: 185 RLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDIL---SGAIVAAIAIAAGMVAV 241
            L    +A+ A        F    +  +      E+              +    G +  
Sbjct: 197 LLICTFLASIASDFVGRRIFGMQTAFNLTVNYPKEINPYFQFGLFVCFGIVIAFFGKIFT 256

Query: 242 WCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDY 301
             L ++  +    K P             +     P     G + +++M      +    
Sbjct: 257 MTLVKIQDIYKGAKLPRWAKVSFVMTTSFILCFILPEVTGGGHELVEEMAGGNR-TIKLL 315

Query: 302 FLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHV------PAVPAAITVSCA 355
            ++ V+KL    ++ A+GF GG   P + +G  LG +    +              +   
Sbjct: 316 VIIFVVKLLFTALSYATGFAGGIFLPMLVLGAILGKIYGILLVNILGVGPEFIPHYMVLG 375

Query: 356 ILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL-----AGKPMMMVNRPK 410
           + G  + V R       +   +  N   L  L  V + A+ +           ++  +  
Sbjct: 376 MAGYFVAVVRAPITGAVLILEMTGNFDHLLALVTVSVIAYYITDLLGLEPIYEILYEKMA 435

Query: 411 QQPPHDNV 418
           +  P + V
Sbjct: 436 KDVPSEKV 443



 Score = 41.3 bits (96), Expect = 0.070,   Method: Composition-based stats.
 Identities = 27/209 (12%), Positives = 58/209 (27%), Gaps = 21/209 (10%)

Query: 3   HPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGV 62
           +P+           V  GI  +    +       +Q++           A+      +  
Sbjct: 228 YPKEINPYFQFGLFVCFGIVIAFFGKIFTMTLVKIQDIYKG--------AKLPRWAKVSF 279

Query: 63  LTLTGIAVGLVIRFSQGHAGPDPACEPLIGAPVPPSA--LPGLIVALILGLAGGVSLGPE 120
           +  T   +  ++    G               +          ++   L  A G + G  
Sbjct: 280 VMTTSFILCFILPEVTGGGHELVEEMAGGNRTIKLLVIIFVVKLLFTALSYATGFAGGIF 339

Query: 121 HPIMTVNIALAVAIGARLLP-----RVNRMEWTILASAGTIGALFGTPVAAALIFSQTLN 175
            P++ +   L    G  L+            + +L  AG   A+   P+  A++  +   
Sbjct: 340 LPMLVLGAILGKIYGILLVNILGVGPEFIPHYMVLGMAGYFVAVVRAPITGAVLILEMTG 399

Query: 176 GSSEVPLWDRLFAPLMAAAAGALTTGLFF 204
                  +D L A +  +      T L  
Sbjct: 400 N------FDHLLALVTVSVIAYYITDLLG 422


>UniRef50_C9LB15 Voltage-gated chloride channel family protein n=13
           Tax=Clostridiales RepID=C9LB15_RUMHA
          Length = 527

 Score =  242 bits (619), Expect = 2e-62,   Method: Composition-based stats.
 Identities = 65/423 (15%), Positives = 132/423 (31%), Gaps = 18/423 (4%)

Query: 1   MLHPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWII 60
           ++    R   +L+     +G  + L++++   I       + + L         + LW +
Sbjct: 14  LMKRAERFKTILTAEGFLVGAVAGLVVLLYRVILEYAGKGMNKVLEYARQEPFAAVLWFV 73

Query: 61  GVLTLTGIAVGLVIRFSQGHAGPDPACEPLIGAPVPP---SALPGLIVALILGLAGGVSL 117
            +  +  I   LV           P  E  +   +       LP   +   L L  G+SL
Sbjct: 74  ALFVIACIVGKLVKYEPMISGSGIPQVEGEMMGKLNQVWQRVLPAKFLGGFLSLFAGLSL 133

Query: 118 GPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNG 176
           G E P + +      A+   L   +          ++  + A F  P+A  +   + ++ 
Sbjct: 134 GREGPSIQIGAMTGKAVSQTLDRGKTEEKYLITCGASAGLAAAFHAPLAGVMFSLEEIHK 193

Query: 177 SSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAA 236
           +  V     L + + A+      +  F             +M         I+  I    
Sbjct: 194 NFSV---SVLISVMTASITADYISSQFMGFQPVFQFDVGTEMPPQYYWHIVILGVILGIM 250

Query: 237 GMVAVWCLPRLHAMMHQMKN-PVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQA 295
           G         +  +  + K           F L  +  +  P  L  G   +  M A   
Sbjct: 251 GAFYNKMTMWVQGLYLKSKKLNETTRLFIPFFLAGVLGLVMPQILGSGHALI-DMAAEGN 309

Query: 296 FSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEH------VPAVPAA 349
              +   +L   K    ++   SG  GG  FP + +G  LG            + A   +
Sbjct: 310 LMLTSLLILFAAKFLFSLICFGSGAPGGIFFPLLVLGALLGGAYSTFAVQYMGLDASYIS 369

Query: 350 ITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGK---PMMMV 406
             V  A+ G    + R     + +   +    + +  + +V + A+L+ +     P+   
Sbjct: 370 NMVLLAMAGYFTAIVRAPITGIILIFEMTGQVSQMLSMSLVSIVAYLVASALKSEPIYES 429

Query: 407 NRP 409
              
Sbjct: 430 LLS 432


>UniRef50_Q189E6 Chloride ion channel protein n=10 Tax=Bacteria RepID=Q189E6_CLOD6
          Length = 524

 Score =  241 bits (615), Expect = 5e-62,   Method: Composition-based stats.
 Identities = 65/416 (15%), Positives = 138/416 (33%), Gaps = 18/416 (4%)

Query: 9   MLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGI 68
            ++L    + +G  + LI+++   +       L Q L    G       W   +  L  I
Sbjct: 16  QVILIGEGLMVGAVAGLIVLLYRILLGQAGTWLSQILKFVEGSTIKIIAWFAVLAVLAWI 75

Query: 69  AVGLVIRFSQGHAGPDPACEPLIGAPVP---PSALPGLIVALILGLAGGVSLGPEHPIMT 125
              LV           P  E  +   +       LP   +   L L GG++LG E P + 
Sbjct: 76  VSKLVDWEPMISGSGIPQLEGEMTGKIKQVWWRVLPTKFIGGFLSLMGGLALGREGPSIQ 135

Query: 126 VNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWD 184
           +       I   L   +          ++  + A F  P+A  +   + ++ +  V    
Sbjct: 136 LGAMAGKGISRALDRGKTEEKFLLTCGASAGLSAAFHAPLAGVMFSLEEVHKNFSV---S 192

Query: 185 RLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCL 244
            L + + A+      +  F              +         I+  I    G    W  
Sbjct: 193 VLISVMTASLTADYISANFLGMESVFQFDIGNVLPQDYYGLIVILGVILGVMGAFYNWFT 252

Query: 245 PRLHAMMHQMKNPVLV-LGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFL 303
             + ++  ++         +  FI+  +  I  P  L  G + ++++ +++        L
Sbjct: 253 LYVQSLYKKIPKIGTFGKLLIPFIMAGILGIVMPDVLGSGHNLVEELTSHEYI-FGMVVL 311

Query: 304 LAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEH------VPAVPAAITVSCAIL 357
           + VI+     V+  SG  GG  FP + +G  +G +          +        V  A+ 
Sbjct: 312 IFVIRFIFSAVSFGSGAPGGIFFPLLVLGAFIGGIFGMVGVKVFGMNPDYVNNFVLLAMA 371

Query: 358 GIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL---AGKPMMMVNRPK 410
           G    + R     + +   +  + + +  L ++ + A+++      KP+      +
Sbjct: 372 GYFTAIVRAPLTGIILIFEMTGSVSQMLSLSVISIVAYIVATLMKSKPIYESLLER 427


>UniRef50_Q39PZ5 Cl-channel, voltage gated n=4 Tax=Desulfuromonadales
           RepID=Q39PZ5_GEOMG
          Length = 613

 Score =  240 bits (614), Expect = 6e-62,   Method: Composition-based stats.
 Identities = 59/411 (14%), Positives = 130/411 (31%), Gaps = 18/411 (4%)

Query: 5   RARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSP----LWII 60
           R     L+++ AV IG+ + L            + L+        G + D+     LW +
Sbjct: 43  RISESTLMAVLAVGIGLLAGLCNYAFRSCIDFFRWLIIDNGARLTGYSPDTWDASRLWAL 102

Query: 61  GVLTLTGIAVGLVIRFSQG----HAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVS 116
               +    +  +  + +               L G  +P   +    ++  L +  G S
Sbjct: 103 AFPVIGATIMLPLFIWYREDMAFGFPRFLERVNLRGGRLPLRLMFTRGISSALTIGSGGS 162

Query: 117 LGPEHPIMTVNIALAVAIGARLLPRVNR-MEWTILASAGTIGALFGTPVAAALIFSQTLN 175
            G E PI  +       +G  L     R         +G + A F  P+A      + + 
Sbjct: 163 AGQEGPIAQIGGTAGSVVGHLLGMPEERLKVLIGCGVSGGVAATFNAPLAGVFFAHEIVL 222

Query: 176 GSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIA 235
            SS         + ++++    + +   +    +  +  Y  +   +++  A++  +   
Sbjct: 223 LSSFE--LSSFTSIVISSGMATVVSRAMYGDIPAFDVPAYQLVHPLELVLYALLGIVCGC 280

Query: 236 AGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQA 295
              + +    +      Q++   L   + G  L     +  P     G   +++ V    
Sbjct: 281 VAALFITGYGKTREFFEQLRVNPLWKPLLGGFLAGCVGVLLPQVQGNGYGFIEKAV-GND 339

Query: 296 FSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVP------AA 349
                  LL V K+AA  V   SG  GG   P++F+G   G+        +         
Sbjct: 340 VGWLLVTLLIVGKMAATCVTIGSGLPGGTFAPSLFIGSVTGMSFGFLANLLFPLHTATPG 399

Query: 350 ITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAG 400
                 +   +  VT      +F+   +  +  ++  + +       +   
Sbjct: 400 AYALVGMGAFLASVTHAPMTGIFLLFEMTGSYKVIIPIMLACSIGTAVARH 450


>UniRef50_B5YZU3 Putative ion-transport protein yfeO n=97 Tax=Enterobacteriaceae
           RepID=YFEO_ECO5E
          Length = 418

 Score =  240 bits (612), Expect = 1e-61,   Method: Composition-based stats.
 Identities = 418/418 (100%), Positives = 418/418 (100%)

Query: 1   MLHPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWII 60
           MLHPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWII
Sbjct: 1   MLHPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWII 60

Query: 61  GVLTLTGIAVGLVIRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPE 120
           GVLTLTGIAVGLVIRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPE
Sbjct: 61  GVLTLTGIAVGLVIRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPE 120

Query: 121 HPIMTVNIALAVAIGARLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEV 180
           HPIMTVNIALAVAIGARLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEV
Sbjct: 121 HPIMTVNIALAVAIGARLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEV 180

Query: 181 PLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVA 240
           PLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVA
Sbjct: 181 PLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVA 240

Query: 241 VWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSD 300
           VWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSD
Sbjct: 241 VWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSD 300

Query: 301 YFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIV 360
           YFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIV
Sbjct: 301 YFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIV 360

Query: 361 LVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNRPKQQPPHDNV 418
           LVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNRPKQQPPHDNV
Sbjct: 361 LVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNRPKQQPPHDNV 418


>UniRef50_B9XDX3 Chloride channel core n=1 Tax=bacterium Ellin514 RepID=B9XDX3_9BACT
          Length = 614

 Score =  238 bits (609), Expect = 2e-61,   Method: Composition-based stats.
 Identities = 66/391 (16%), Positives = 135/391 (34%), Gaps = 20/391 (5%)

Query: 28  IVVMKIASVLQNLLWQRLPGTLGIAQ-DSPLWIIGVLTLTGIAVGLVIRFSQGHAG---- 82
           +V      + Q L   R    + +A+   PL  + + T+  +  G+V+ +     G    
Sbjct: 57  LVFHYGIDISQQLFLHRSGDIVAVAEKVPPLERLVISTVGALLAGVVLYWGLRLVGKQGS 116

Query: 83  -PDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARLLPR 141
                        +P        ++ +L +  G S+G E  I  +    A   G     +
Sbjct: 117 SNILEVVVASDGRLPFRTTIVKAISSLLSIGSGASIGREGAITNLAATFASKWGQLCRWQ 176

Query: 142 VNR-MEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTT 200
             R        +A  I A +  P+A A+  +  + G+  + L       + ++   ++ +
Sbjct: 177 PYRLRLLVACGAASGISAAYNAPIAGAVFAALIVLGNFSMNL---FAPLVFSSVVASMVS 233

Query: 201 GLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLV 260
             FF       +  +    +T +    ++  +    G V +  L     +  ++  PV V
Sbjct: 234 RSFFGLKPWYEVTQFDFKSLTQLPWFLLLGIVTGVMGAVFLKMLAWSEEIFKRVPAPVYV 293

Query: 261 LGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAF----STSDYFLLAVIKLAALVVAA 316
               G        +  P     G     +++  Q             L + KL A +   
Sbjct: 294 RLALGGFFAGCLAMAFPQVWGNGYGITNRILHEQFLNESSPLIFLIGLFLAKLLATLATV 353

Query: 317 ASGFRGGRIFPAVFVGVALGLMLHEHVP------AVPAAITVSCAILGIVLVVTRDGWLS 370
            SG  GG   P +F+G  LG +    +        +P ++     +  ++   TR   L+
Sbjct: 354 GSGAVGGVFTPTLFLGAGLGYIFGAGLHDAGQGMVLPTSVFTLVGMGSMLAATTRSPLLA 413

Query: 371 LFMAAVVVPNTTLLPLLCIVMLPAWLLLAGK 401
           + M   V  N +L+P L +  + + L+    
Sbjct: 414 MIMVFEVSLNYSLMPPLMLACVVSTLMARRL 444


>UniRef50_A3CW01 Cl-channel, voltage-gated family protein n=3 Tax=Methanomicrobiales
           RepID=A3CW01_METMJ
          Length = 754

 Score =  238 bits (609), Expect = 2e-61,   Method: Composition-based stats.
 Identities = 69/451 (15%), Positives = 134/451 (29%), Gaps = 46/451 (10%)

Query: 9   MLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPG-------------TLGIAQDS 55
              + L AV +G+ + L  +   +   +      + + G                   D+
Sbjct: 136 YRRVILIAVIVGLIAGLGALFFFEGLKLGTAFFMEGIVGFQIPKEGQNLQDIAQWAPPDN 195

Query: 56  PLWIIGVLTLTGIAVGLVIRFSQ---GHAGPDPACEPLIG-APVPPSALPGLIVALILGL 111
              I+ V+   G+  GL++          G D A +   G   V         V  +L +
Sbjct: 196 LWMILPVICFGGLLSGLLVYTFAPEAEGHGTDAAIKAFHGEGRVRWRVPLVKAVTAVLTI 255

Query: 112 AGGVSLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIF 170
           + G S G E P   ++          L L    R           IG +F  P+  A++ 
Sbjct: 256 STGGSAGREGPTAQMSAGFGSIAADLLGLSARERRLAIATGVGAGIGTIFMAPLGGAILA 315

Query: 171 SQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVA 230
           ++ L         + +    +A+  G    GL                 ++ I    ++ 
Sbjct: 316 AEILYRQDFET--EAIVPAFLASVIGYAIFGLVEGFEPVFG-PGVTSWNVSQIPFFILLG 372

Query: 231 AIAIAAGMVAVWCLPRLHAMMH----QMKNPVLVLGIGGFILGIL-----------GVIG 275
            ++ A G++ +      + +      ++K P     + G  L                I 
Sbjct: 373 VVSTAIGLIYINTFYGTNRIFKKVFSRLKIPNHFKPLAGAFLTGTFVLALAALSPEAAIV 432

Query: 276 GPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVAL 335
           G  SL  G    Q  + N          L   K+    +   SG  GG   P + +G A 
Sbjct: 433 GLGSLGTGYGFAQLALYN-MLPVGVLLFLPFAKILTTSLTIGSGGSGGVFAPGLVIGGAT 491

Query: 336 GLMLHEHVPAVPAAI--------TVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLL 387
           G      +      I             ++ +   ++      + M   +  + +LL   
Sbjct: 492 GGAFGSLLHLALPGIIPAESVPVFFIVGMIALFGAISHAPIAVMIMVVEMTGDFSLLVPA 551

Query: 388 CIVMLPAWLLLAGKPMMMVNR-PKQQPPHDN 417
              +  A +L+    +       + Q P   
Sbjct: 552 MGAVSVAVILIGQSTIFREQVLNRSQSPAHR 582


>UniRef50_Q0TP43 Voltage-gated chloride channel family protein n=9 Tax=Clostridium
           perfringens RepID=Q0TP43_CLOP1
          Length = 519

 Score =  238 bits (607), Expect = 4e-61,   Method: Composition-based stats.
 Identities = 56/370 (15%), Positives = 129/370 (34%), Gaps = 17/370 (4%)

Query: 42  WQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRFSQGHAGP-DPACEPLIGAPVP---P 97
           + ++           + +  VL   G  VG++++ +    G   P  E  +   +     
Sbjct: 46  FNKVYSYTRENPKLIIPLFLVLIFLGFIVGIIVKKNPMIGGSGIPQVEGELSGKISVNWL 105

Query: 98  SALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTI 156
                  +  I+ +A G+SLG E P + +  ++              +       ++  +
Sbjct: 106 RVFKDKFIGGIICMASGLSLGKEGPSVQIGASIGEGFAKIFKRSDFEKRLLITGGASSGL 165

Query: 157 GALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYG 216
             +F  P++ A+   + ++ S  +P    + A L A+  G     L     F + I    
Sbjct: 166 AVIFNAPLSGAIFALEEVHRSFSLP---VMLAALSASLTGVFVDNLILGNDFCIKIPPIN 222

Query: 217 QMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQ--MKNPVLVLGIGGFILGILGVI 274
            + +    +  I+ AI    G +    L +      +   K P+    I  F++  +  +
Sbjct: 223 SLPIQYYWTLLILGAILGVTGWIFNKGLLKTQDFYVKTLKKIPIQFKTIIPFVMVGILAL 282

Query: 275 GGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVA 334
             P ++  G   ++ ++     +     ++ VIK      + +SG  GG  FP + +G  
Sbjct: 283 TIPEAIDGGDSLIESVI-GNNIAIKLLIVILVIKFIFTFFSYSSGVPGGIFFPLLAIGAL 341

Query: 335 LGLMLHEHVP------AVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLC 388
           +G +    +              +  A+      + +     L +   +      L  + 
Sbjct: 342 VGAIFGLLLNKYLGISDSLIVNFIVLAMAAQFASIVKAPITGLMLITEMTGTFKHLLPVA 401

Query: 389 IVMLPAWLLL 398
           I +  A+L+ 
Sbjct: 402 ITVTVAYLVS 411


>UniRef50_A4GJ08 Putative CBS:IMP dehydrogenase/GMP reductase:voltage-gated
           Cl-channel n=1 Tax=uncultured marine Nitrospinaceae
           bacterium RepID=A4GJ08_9DELT
          Length = 584

 Score =  238 bits (607), Expect = 4e-61,   Method: Composition-based stats.
 Identities = 64/397 (16%), Positives = 135/397 (34%), Gaps = 18/397 (4%)

Query: 12  LSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGI-AQDSPLWIIGVLTLTGIAV 70
           + L A  IG  + L   +  ++    + +        +GI     PL +  +  + GI  
Sbjct: 22  MLLLAAVIGFLAGLASTLFRRLIEFFEVIFSADGLVFIGITGTTVPLLLPLMPMIGGIIT 81

Query: 71  GLVIRFSQGHAGP-----DPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMT 125
           G++  F                  L    +    L        L +  G S G E P + 
Sbjct: 82  GVICHFFPDAVKENGVHRVMHAVALKAGKIRKRTLLTCSTTSALTIGSGGSAGREGPTVQ 141

Query: 126 VNIALAVAIGARLLPRVNR-MEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWD 184
           +  A+  A+G        R        +A  I A F  P+A  L   + +  +  +    
Sbjct: 142 IGSAVGSALGNMFHLSHERIQVLVGCGAAAGIAASFNAPLAGVLFALEIILTNFTI---H 198

Query: 185 RLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCL 244
                ++A+  G  T         +  +  +  +  ++I+    +  +      +  +  
Sbjct: 199 TFSPIVVASVIGTATGRAMEGNQITFHVPVHELVSYSEIVFYLFLGILCGVVSKLFTFAY 258

Query: 245 PRLHAMMH-QMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFL 303
            + H +   ++K P  +    G ++     I  P  L  G D M++ +  + F     F+
Sbjct: 259 FKAHDIFDKKVKLPKPLKPALGGLIVGFIAILFPAVLGNGYDFMEKALNGELF-WGLAFV 317

Query: 304 LAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAI------TVSCAIL 357
           L  +K+ +      SG  GG   P++F+G  LG      V  +  +            + 
Sbjct: 318 LIFLKIISTSATLGSGGLGGVFAPSLFIGAMLGSAYGTLVHTINPSFTASPETYALVGMG 377

Query: 358 GIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPA 394
            +   V +    ++ M   +  + T++  + I  + +
Sbjct: 378 AVAGAVMQAPLTNILMLFELTNDYTIILPIMITCIVS 414


>UniRef50_B1C8T2 Putative uncharacterized protein n=2 Tax=Clostridiales
           RepID=B1C8T2_9FIRM
          Length = 536

 Score =  237 bits (606), Expect = 5e-61,   Method: Composition-based stats.
 Identities = 62/396 (15%), Positives = 131/396 (33%), Gaps = 15/396 (3%)

Query: 3   HPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGV 62
           + + R+ +   +    IGI + L+ I+   + +  + LL+  +    G      LW++ +
Sbjct: 17  NKKGRSQIEFIIEGFLIGIVAGLVAIIYRLLLTKAEKLLFFAVDYIHGDVVKIILWMLFL 76

Query: 63  LTLTGIAVGLVIRFSQGHAGPDPACEPLIGAPV---PPSALPGLIVALILGLAGGVSLGP 119
             L  I   LV           P     +   +   P   +   I+   L + GG+SLG 
Sbjct: 77  TVLAIIVGKLVKWEPMISGSGIPQVSGEMKGYLSQNPVKVIIAKIIGGTLSIVGGLSLGR 136

Query: 120 EHPIMTVNIALAVAIGARLLPR-VNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSS 178
           E P + +       +             +    +   + A F  P+A  +   + ++ + 
Sbjct: 137 EGPSIQLGAMAGKKLAQVQKKGKTKEKTYISCGAGAGLAAAFNAPLAGVMFTLEEIHKNF 196

Query: 179 EVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGM 238
           +      + + + AA          F             + +T      I+  I   +G 
Sbjct: 197 D---GRVIVSVMTAAVTADFLAKSVFGLSTVFQYNSSTPIPLTLYGLVIILGIIVGVSGA 253

Query: 239 VAVWCLPRLHAMMHQMK-NPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFS 297
               C+ +   +  ++K        I  F++  +  +  P  L  G   M  ++    F 
Sbjct: 254 FYNKCMVKGQKLYAKLKMIKPEYRIIIPFLVAGVFALVYPKVLAGG-SVMVDILVKNNFV 312

Query: 298 TSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEH------VPAVPAAIT 351
            S    + +IK    V+   SG  GG  +P + +G  +G            V  +     
Sbjct: 313 LSALLTMLIIKFLYSVICFGSGAPGGIFYPLLVLGSFIGASFGIVCISSLGVNDIFMDKF 372

Query: 352 VSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLL 387
           +  A+ G      R     + + A +  +   +  +
Sbjct: 373 IILAMAGFFAATVRAPITGIILIAEMTGSLEHMISI 408


>UniRef50_C5VU16 Voltage gated chloride channel family protein n=5 Tax=Clostridia
           RepID=C5VU16_CLOBO
          Length = 530

 Score =  237 bits (606), Expect = 5e-61,   Method: Composition-based stats.
 Identities = 55/415 (13%), Positives = 136/415 (32%), Gaps = 18/415 (4%)

Query: 10  LLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIA 69
             L +    +G  +  I+++       +     +             +W +  + ++ I 
Sbjct: 21  FKLVIEGALVGFFAGFIIVLYRLGVEKIWGYTRKHFVLKTHTLGSVSMWFLIFIIVSLII 80

Query: 70  VGLVIRFSQGHAGPDPACEPLIGAPVPPSAL---PGLIVALILGLAGGVSLGPEHPIMTV 126
             +V +         P  E ++   +  + L    G     IL + GG+SLG E P + +
Sbjct: 81  GQIVKKEPMISGSGIPQVEGILLRKLKMNWLTVIIGKFFGGILAIGGGLSLGREGPSIQI 140

Query: 127 NIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDR 185
             ++           +V         ++  + A F  P+A  +   + ++ +        
Sbjct: 141 GASVGQGFSRIFKRIKVEEKYLITSGASAGLAAAFNAPLAGVMFALEEIHKNFSP---LI 197

Query: 186 LFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLP 245
           L + + A+      +  FF             + +       I+  I    G++    + 
Sbjct: 198 LISAMSASLTADCVSKYFFGLRPVFDFNLISPIPLKYYFYLIILGIITGLFGVLFNKMIL 257

Query: 246 RLHAMMHQMKN-PVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLL 304
           +   +  + K     V  +  F++  +  I  P  L  G   +  +     ++    F++
Sbjct: 258 KTQDLYGKAKWLKPEVKPVVPFMVAGILAIVYPNGLGSGHGLIIHLFHEN-WTLKMLFII 316

Query: 305 AVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEH------VPAVPAAITVSCAILG 358
            V+K    ++   SG  GG   P + +G   G +  E       +  +     +  ++  
Sbjct: 317 LVVKFLFTMICYGSGVPGGIFLPLLIIGAITGNIYGEVLVKLIHLNPIYVRNFIVLSMAA 376

Query: 359 IVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL---AGKPMMMVNRPK 410
               + R       +   +  + + L  L +V + A+++       P+      +
Sbjct: 377 YFTAIVRAPITGSILITEMTGSFSNLLSLSVVSIVAYVVSDMLKSAPIYESLLER 431



 Score = 47.9 bits (113), Expect = 7e-04,   Method: Composition-based stats.
 Identities = 21/202 (10%), Positives = 61/202 (30%), Gaps = 20/202 (9%)

Query: 7   RTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLT 66
           +    L +  +     + L  ++  K+    Q+L  +       +       ++  +   
Sbjct: 233 KYYFYLIILGII----TGLFGVLFNKMILKTQDLYGKAKWLKPEVKP-----VVPFMVAG 283

Query: 67  GIAVGLVIRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTV 126
            +A+        GH              +    L    +  ++    GV  G   P++ +
Sbjct: 284 ILAIVYPNGLGSGHGLIIHLFHENWTLKMLFIILVVKFLFTMICYGSGVPGGIFLPLLII 343

Query: 127 NIALAVAIGARL-----LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVP 181
                   G  L     L  +    + +L+ A    A+   P+  +++ ++         
Sbjct: 344 GAITGNIYGEVLVKLIHLNPIYVRNFIVLSMAAYFTAIVRAPITGSILITEMTGS----- 398

Query: 182 LWDRLFAPLMAAAAGALTTGLF 203
            +  L +  + +    + + + 
Sbjct: 399 -FSNLLSLSVVSIVAYVVSDML 419


>UniRef50_Q6AIP2 Related to chloride channel protein n=1 Tax=Desulfotalea
           psychrophila RepID=Q6AIP2_DESPS
          Length = 695

 Score =  237 bits (604), Expect = 9e-61,   Method: Composition-based stats.
 Identities = 61/412 (14%), Positives = 129/412 (31%), Gaps = 40/412 (9%)

Query: 21  IASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRFSQGH 80
           + + +  ++ +K+  ++Q+  +  +     I        +    + G+ VG +I  ++  
Sbjct: 34  VITGVGSVIFIKLIHLIQSFFYTGVYEK--IPFLGKWIYVVAPVIGGLLVGPLILLAKEA 91

Query: 81  AGP----DPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGA 136
            G           L G  +        IVA  + +  G S G E PI+ V  A   ++G 
Sbjct: 92  KGHGVPEVMQALVLRGGRIRGRVAAAKIVASAICIGTGGSAGREGPIIQVGAAFGSSLGQ 151

Query: 137 RLLPRVNR-MEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAA 195
            L     R        +A  I A F  P+A  +   + L  +  +         ++++ A
Sbjct: 152 ILKLSDERIRNLVACGAAAGIAATFNAPIAGVVFAIEVLMFNIHI---RAFGNVVISSVA 208

Query: 196 GALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMK 255
            ++ + LF     +  +  Y      +++   I+   A   G+  +  L     +     
Sbjct: 209 ASIVSRLFLGHGAAFAVPTYTMANPVELVLYFILGLTAALVGVFFIRILDVAETVFDNWD 268

Query: 256 NPVLVLGIGGFILGILGVIGG-----------------------PVSLFKGLDEMQQMVA 292
            P +     G     +  +                         P     G   +   + 
Sbjct: 269 FPQIFKPAVGAACLGVIGLIYMSFPGFVDPNATGVHGPITAAPIPHMFGTGFPFIGYALQ 328

Query: 293 NQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAI-- 350
            +  S     +L  +K  A      SG  GG   P++F G  LG  +          I  
Sbjct: 329 GKG-SFWVLLMLVFLKPLATTFTLGSGNSGGVFAPSLFTGAMLGGAMGHVFLYFFPGITG 387

Query: 351 ----TVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL 398
                    +  +     R    ++ +   +  +  ++  L I  + A  + 
Sbjct: 388 NIGAYALVGMAALFSATARAPLTAMLIVFEMSGDYEMILPLMIAGVTACYVA 439


>UniRef50_Q892T8 Chloride channel protein n=1 Tax=Clostridium tetani
           RepID=Q892T8_CLOTE
          Length = 526

 Score =  236 bits (603), Expect = 1e-60,   Method: Composition-based stats.
 Identities = 58/417 (13%), Positives = 134/417 (32%), Gaps = 19/417 (4%)

Query: 10  LLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIA 69
             L L ++ +G+ + +++++   +   + N     L      +          L + GI 
Sbjct: 18  FRLILESILVGLITGIVVVLFRILLDKVTNFRNYALIFIKNNSIVYVGMWFLFLIIAGIV 77

Query: 70  VGLVIRFSQGHAGP-DPACEPLIGAPVP---PSALPGLIVALILGLAGGVSLGPEHPIMT 125
            G++I       G   P  + +    +       L       +  L  G+SLG E P + 
Sbjct: 78  FGILIEKIPMIKGSGIPQVKGVFLRQLKMDWLRELVAKFFGGVASLGIGLSLGREGPSVQ 137

Query: 126 VNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWD 184
           +   + +                    ++  + A F  P+A  +   + L+ S       
Sbjct: 138 LGSEVGLGFCRVFKRRPFEEKYLITSGASAGLSAAFNAPLAGVVFSLEELHKSFN---SL 194

Query: 185 RLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCL 244
            L   + A+ A    +  F          +   + +       ++  I   +G +  + +
Sbjct: 195 VLACAMGASLAANFISTRFLGLKPVFSFENVKALPLNKYHYLILLGIIIGISGRIFNYSI 254

Query: 245 PRLHAMMHQMKN-PVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFL 303
            ++  +   +K        +  FI+  +  +  P  L  G   ++ +  N+ F  S   +
Sbjct: 255 LKVQDIYKDIKVLKNRYKTVIPFIVTGVIGLTVPEMLGGGHSLVENLSKNE-FLLSTLLI 313

Query: 304 LAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEH------VPAVPAAITVSCAIL 357
             ++K    +V   SG  GG   P + +G  +G            +P+         A+ 
Sbjct: 314 FIIVKFLFTIVCYGSGVPGGIFLPLLALGALIGKTYGVTLVEYANLPSGYIINFTILAMA 373

Query: 358 GIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGK---PMMMVNRPKQ 411
                +TR       +   +  +      L ++   A+L+       P+      + 
Sbjct: 374 ANFTAITRAPITGSILILEMTNSFNSFLELMVITTVAYLIADILNVHPIYDSLLERM 430


>UniRef50_D2BKV3 Chloride channel protein n=4 Tax=Lactococcus lactis
           RepID=D2BKV3_LACLK
          Length = 512

 Score =  236 bits (602), Expect = 1e-60,   Method: Composition-based stats.
 Identities = 65/401 (16%), Positives = 140/401 (34%), Gaps = 16/401 (3%)

Query: 8   TMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTG 67
             L L   +V +G+ +  +  +        +                 PL I+G+  L  
Sbjct: 12  KNLYLLFLSVLVGLTAGFLASLYRLALEKAETWGLSIYRFVSSHIIFIPLLILGLAFLAF 71

Query: 68  IAVGLVIRFSQGHAGPDPACEPLIGAPVP---PSALPGLIVALILGLAGGVSLGPEHPIM 124
           +    + ++        P  +  +         +      +A  L +  G+SLG E P +
Sbjct: 72  VVTFFMKKYPMSSGSGIPQVKGQLQGYFKNNWFTTAFAKFIAGTLAMFAGLSLGREGPSV 131

Query: 125 TVNIALAVAIGARLL-PRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLW 183
            +  ++   + +RL     ++       ++  + A F  P++  +   + +         
Sbjct: 132 QLGASMGQMVSSRLAETERHKRILIASGASAGLSAAFNAPLSGVMFTLEEVFKYFSP--- 188

Query: 184 DRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWC 243
             L   + +A    +   + F           G +E+++     I+  I    G    W 
Sbjct: 189 LILLTCMTSAMVADMVARIMFGSGPVFHFQIVGSIELSNYWLLIILGIILGFFGAFYNWT 248

Query: 244 LPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFL 303
           L     +M ++K+P L + +  F++     +  P  +  G   M           +   L
Sbjct: 249 LLTSQNLMKKIKSPFLRVLLT-FLVVGATGLLFPNIIGSGHRLMDSFSLG--MGLAFLCL 305

Query: 304 LAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEH------VPAVPAAITVSCAIL 357
           + + K    +V+ ASG  GG  FP + +G +LG +          +P+   A  V  A+ 
Sbjct: 306 ILIGKYLISMVSYASGVPGGIFFPLLVLGASLGAVFATIVISLFHLPSHLFANLVILAMA 365

Query: 358 GIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL 398
           G    + R     + +   +  +   L  L +V L A+++ 
Sbjct: 366 GTFTAIVRAPMTGILLLVEMTGSFDHLLPLALVSLIAYVVA 406


>UniRef50_B4CXW5 Chloride channel core n=1 Tax=Chthoniobacter flavus Ellin428
           RepID=B4CXW5_9BACT
          Length = 597

 Score =  235 bits (600), Expect = 2e-60,   Method: Composition-based stats.
 Identities = 70/407 (17%), Positives = 138/407 (33%), Gaps = 19/407 (4%)

Query: 1   MLHPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTL-GIAQDSPLWI 59
           ++ P    + L    A  IG A +   +   K+  ++     Q+  G +       PL  
Sbjct: 19  IIRPNELQVTLFW--AGVIGFAGACASVAFRKLTGLVHYAFTQQYSGLVESFEHLRPLQR 76

Query: 60  IGVLTLTGIAVGL-----VIRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGG 114
           + V  + G+  GL     V    +  +        L    +   +     ++ +  +A G
Sbjct: 77  LYVPAIGGVLAGLTIFLGVRWGRRRSSTDYMEAIVLGDGIISFRSSIVKSLSAMFSIASG 136

Query: 115 VSLGPEHPIMTVNIALAVAIGARLLPRV-NRMEWTILASAGTIGALFGTPVAAALIFSQT 173
            S+G E P++ ++  +A  IG                 +A  I + +  P+  AL  ++ 
Sbjct: 137 ASIGREGPLVQLSSMIASLIGRWRKTPTLQLRLLVACGAAAGIASAYNAPIGGALFVAEI 196

Query: 174 LNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIA 233
           +  S  +   +     + ++    LT            IA        +IL   ++  +A
Sbjct: 197 ILQSLAM---ESFGPLVFSSVVSTLTVRQLLGEQPLYEIASVHLGSNWEILPLMLLGLVA 253

Query: 234 IAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVAN 293
                  +  L     M  ++  P  V    G ++  L  I  P     G   + +++  
Sbjct: 254 GLFAPWFLRLLRASERMFSKLALPTYVRLGLGGLIVGLLAIWQPEVCGNGYSVVNEILHG 313

Query: 294 QAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALG-LMLHEHVPA-----VP 347
                     + + KL A      SG  GG   P +FVG  LG L +H   P      + 
Sbjct: 314 N-LLWQALVFILLFKLIATAATFGSGAVGGVFTPTLFVGACLGDLAVHAAQPLWLGTPLN 372

Query: 348 AAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPA 394
             + V   +   +   T    +++ M   +  +  L+  L +  + A
Sbjct: 373 PQVFVVIGMGAFLAATTHAPIMAIIMLFELTLDYQLILPLMLACVIA 419



 Score = 40.9 bits (95), Expect = 0.080,   Method: Composition-based stats.
 Identities = 26/200 (13%), Positives = 57/200 (28%), Gaps = 22/200 (11%)

Query: 221 TDILSGAIVAAIAIAAGMVAVWCLPRLHAMM------------HQMKNPVLVLGIGGFIL 268
             +    ++      A +        +H               H      L +   G +L
Sbjct: 27  VTLFWAGVIGFAGACASVAFRKLTGLVHYAFTQQYSGLVESFEHLRPLQRLYVPAIGGVL 86

Query: 269 GILGVIGGPVS--LFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIF 326
             L +  G          D M+ +V          F  +++K  + + + ASG   GR  
Sbjct: 87  AGLTIFLGVRWGRRRSSTDYMEAIVLGD---GIISFRSSIVKSLSAMFSIASGASIGREG 143

Query: 327 PAVFVGVALGLMLHEH--VPAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLL 384
           P V +   +  ++      P +   + V+C     +              A ++  +  +
Sbjct: 144 PLVQLSSMIASLIGRWRKTPTLQLRLLVACGAAAGIASAYNAPIGGALFVAEIILQSLAM 203

Query: 385 P---LLCIVMLPAWLLLAGK 401
                L    + + L +   
Sbjct: 204 ESFGPLVFSSVVSTLTVRQL 223


>UniRef50_D0MHJ3 Chloride channel core n=1 Tax=Rhodothermus marinus DSM 4252
           RepID=D0MHJ3_RHOM4
          Length = 625

 Score =  235 bits (599), Expect = 3e-60,   Method: Composition-based stats.
 Identities = 65/438 (14%), Positives = 130/438 (29%), Gaps = 34/438 (7%)

Query: 11  LLSLPAVAIGIASSLILIVVMKIASVLQNLLW-----------------QRLPGTLGIAQ 53
                +  IG+  +L  +V  ++ ++L  L+                          +  
Sbjct: 35  RWMFYSAIIGVLGALAALVFGELVTLLTRLILIEGAGYPVPFPRGEGGTDIFDLEQVLHP 94

Query: 54  DSPLWIIGVLTLTGIAVGLVI-RFSQGHAGP----DPACEPLIGAPVPPSALPGLIVALI 108
                ++    + G+  G ++  F+    G                +   A    IVA  
Sbjct: 95  ARRWLLLIAPAVGGLLAGWIVFTFAPEAEGHGTDSVIRAFHRERGFMRLRAGLVKIVAAA 154

Query: 109 LGLAGGVSLGPEHPIMTVNIALAVAIGA-RLLPRVNRMEWTILASAGTIGALFGTPVAAA 167
           L +  G S G E PI  +   L   +     L    R  + +   A  + ++F +P+  A
Sbjct: 155 LTIGSGGSAGREGPITQIGATLGSWLAQRLRLSERERRLFLVAGMAAGLSSIFRSPLGGA 214

Query: 168 LIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGA 227
               + L         + L   ++A+  G                  +  +   ++L   
Sbjct: 215 FFAVEVLYREDIE--SEALMPAIVASITGYSLYTSIERSGTVFVTPRFEFVSPLELLPLI 272

Query: 228 IVAAIAIAAGMVAVWCLPRL-HAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDE 286
             A      G+  V         +   +  P  +    G +L        P  +      
Sbjct: 273 GFALCCAIVGIFYVRVFYGTKRRIFDPLPLPPALKPALGGLLVGAIAFFFPAIMGSSYGW 332

Query: 287 MQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAV 346
           +QQ +           LLA++K+ A  +   SG  GG   P++ +G  LG +  E +  +
Sbjct: 333 LQQAIDGN-LPLGFMALLALLKIFATSLTIGSGGAGGTFAPSLVIGGMLGGLYGEGLHRL 391

Query: 347 PAAI------TVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAG 400
              +       V   +   V         +  M + +  + +LL  L    +   L+   
Sbjct: 392 FPTLITQPEAYVLIGMGTFVGGAANVPIAATIMISEMTGSYSLLVPLIFAGVITHLVARR 451

Query: 401 KPMMMVN-RPKQQPPHDN 417
             +     R     P   
Sbjct: 452 WSLFEEQVRTHNDSPAHR 469


>UniRef50_C1F0W1 Chloride transporter, ClC family n=1 Tax=Acidobacterium capsulatum
           ATCC 51196 RepID=C1F0W1_ACIC5
          Length = 572

 Score =  235 bits (599), Expect = 3e-60,   Method: Composition-based stats.
 Identities = 70/411 (17%), Positives = 129/411 (31%), Gaps = 22/411 (5%)

Query: 6   ARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRL-------------PGTLGIA 52
            R  L   + AV +GI  +   +    +      L  + +             P ++ + 
Sbjct: 6   ERVELRRVVDAVVLGIVGAAAALAFHWMLQFCSWLFLRHIAGYLPPDIAGSIAPHSVAVP 65

Query: 53  QDSPLWIIGVLTLTGIAVGLVIRFSQGHAGPDPACE----PLIGAPVPPSALPGLIVALI 108
             +    +       I+  LV  F+    G                +     P  +VA  
Sbjct: 66  HWNWWIPVATTVGGLISGALVFTFAPEAEGHGTDTVVNAFHRKAGVIRARVAPLKMVASA 125

Query: 109 LGLAGGVSLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAA 167
           + +  G S G E P   +                  R    ++  A  + A+F +P+  A
Sbjct: 126 ITIGSGGSAGREGPTALIAAGFGTLYAKLFKRSDQERRFLILVGMAAGLSAVFRSPIGTA 185

Query: 168 LIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIA-HYGQMEMTDILSG 226
           +   + L  + E      L   L+A+       G+FF       +  H  Q +       
Sbjct: 186 IFAVEVLYSAMEFE-SHILIYTLLASVVAYAVNGIFFGLQPLFHVPAHLLQPDYRAYPWY 244

Query: 227 AIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDE 286
             +   +     +       +  + H +  P +     G +   L  +  P  L  G   
Sbjct: 245 VFLGLASGIVAAILPMVFYGMRDLFHAIPCPRIFKPAIGGLCVGLIALYWPQVLGGGYGW 304

Query: 287 MQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAV 346
           MQ M             L  +K+ +L    +SG  GG   P++F+G  LG +L       
Sbjct: 305 MQ-MSIGGFLPLDILIALLFLKMLSLSFTVSSGGSGGVFAPSLFIGAMLGGILAAAFH-E 362

Query: 347 PAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLL 397
           PAA      +  +     R    ++ M   +     LL    + ++ A+LL
Sbjct: 363 PAAGFAIVGMAAVFGAAARVPMATILMVCEMTGGYQLLVPAGLAVILAFLL 413



 Score = 51.7 bits (123), Expect = 4e-05,   Method: Composition-based stats.
 Identities = 36/209 (17%), Positives = 68/209 (32%), Gaps = 28/209 (13%)

Query: 1   MLHPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWII 60
           +L P  R         +A GI ++++ +V   +  +   +               P   I
Sbjct: 233 LLQPDYRAYPWYVFLGLASGIVAAILPMVFYGMRDLFHAI---------------PCPRI 277

Query: 61  GVLTLTGIAVGLVIRFSQG-HAGPDPACEPLIGAPVPP----SALPGLIVALILGLAGGV 115
               + G+ VGL+  +      G     +  IG  +P     + L   +++L   ++ G 
Sbjct: 278 FKPAIGGLCVGLIALYWPQVLGGGYGWMQMSIGGFLPLDILIALLFLKMLSLSFTVSSGG 337

Query: 116 SLGPEHPIMTVNIALAVAIGARLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLN 175
           S G   P + +   L   + A          + I+  A   GA    P+A  L+  +   
Sbjct: 338 SGGVFAPSLFIGAMLGGILAAAFHEPAAG--FAIVGMAAVFGAAARVPMATILMVCEMTG 395

Query: 176 GSSEVPLWDRLFAPLMAAAAGALTTGLFF 204
           G      +  L    +A     L      
Sbjct: 396 G------YQLLVPAGLAVILAFLLQSWLT 418


>UniRef50_UPI000196B5DC hypothetical protein CATMIT_00127 n=1 Tax=Catenibacterium mitsuokai
           DSM 15897 RepID=UPI000196B5DC
          Length = 521

 Score =  235 bits (599), Expect = 3e-60,   Method: Composition-based stats.
 Identities = 68/408 (16%), Positives = 142/408 (34%), Gaps = 14/408 (3%)

Query: 1   MLHPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWII 60
           +L  R++    L+   + +GI S  + IV   + S  +++ +             PLWII
Sbjct: 11  VLRERSKLNKRLAYEGLLVGIVSGAVCIVYRLVLSNAESIYFTIRDFVAHNVSYWPLWII 70

Query: 61  GVLTLTGIAVGLVIRFSQGHAGPDPACEPLIGAPVP---PSALPGLIVALILGLAGGVSL 117
           G++ L  I    +           P  E  +   +       L     A  L L GG+SL
Sbjct: 71  GLIVLGLIISIFLKWEPMIGGSGIPQLEAEVQGRIDECWWRVLLAKFCAGALALVGGLSL 130

Query: 118 GPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNG 176
           G E P + +   +  A+  +    +          +A  + A F  P+A  +   + ++ 
Sbjct: 131 GREGPSIQLGGMIGKALAKKGKRVKTEERYLMTAGAAAGLSAAFNAPLAGIMFALEEVHK 190

Query: 177 SSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAA 236
           +        L + ++A+      +   F    +L  +      + + +   I+  +A   
Sbjct: 191 NFST---SALVSVMIASITADFLSRNIFGLSPTLAFSIKETFPLKNYIWVIILGIVAGVL 247

Query: 237 GMVAVWCLPRLHAMMHQMK-NPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQA 295
           G            +  +          I   +L  +     P+ +  G   ++ +     
Sbjct: 248 GAFYNKVTMGTIKLYKKTPSLKKHQRVIIPLVLSGILGFYCPLVMGGGHKLVEYL-NEPN 306

Query: 296 FSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEH-----VPAVPAAI 350
              S   LL ++KL    V+  SG  GG  FP + +G  +G  + +      VP+     
Sbjct: 307 LVLSTLVLLFILKLLISCVSFGSGAAGGIFFPLLILGSLIGASVGKVAIMCGVPSEYFMN 366

Query: 351 TVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL 398
            +  A+      + R     + + A +     +L  + +V   ++ + 
Sbjct: 367 FIIMAMAAYFSAIVRAPITGIVLIAEMSGTLKMLLPIALVSFVSYYVA 414


>UniRef50_D1AKC6 Chloride channel core n=2 Tax=Fusobacteriaceae RepID=D1AKC6_SEBTE
          Length = 563

 Score =  234 bits (597), Expect = 6e-60,   Method: Composition-based stats.
 Identities = 60/406 (14%), Positives = 133/406 (32%), Gaps = 21/406 (5%)

Query: 7   RTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLT 66
           +  LLL   ++  G  S  ++I+       +  L  +       ++  +    I +  L 
Sbjct: 19  KHNLLLIFYSLLTGTLSGAVVILYRLGLDKIGILREKLFE---NLSVWNFCTGIFIFILI 75

Query: 67  GIAVGLVIRFSQGHAGP-DPACEPLIGAPVPPSALP---GLIVALILGLAGGVSLGPEHP 122
           G+ +  ++      +G   P  + L+   +    LP         +L +  G+SLG E P
Sbjct: 76  GVILQFLVMKFPLISGSGIPQVKALLMQKIHFRWLPELILKFFGGLLSIGVGLSLGREGP 135

Query: 123 IMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVP 181
            + +   +   I        + +  +    ++  + A F  P+A  +   + L+      
Sbjct: 136 SIHLGALVGEGINEVTGRSEMEKKYFITCGASAGLAAAFNAPLAGVIFALEELHKFFSPL 195

Query: 182 LWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDIL---SGAIVAAIAIAAGM 238
           L   L   L+A+      T +F   H           E   ++      I   I    G 
Sbjct: 196 L---LICTLIASITADFLTRIFLGYHPVFNFEVTAPTEFNSLMEIFLILIFGIIMSFMGK 252

Query: 239 VAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFST 298
           +    L +   +  ++         G  ++              G + ++++        
Sbjct: 253 LFSDNLIKFQKVYKKIDLNPYFKAAGLMLIAFFTAFLFKDITGGGHNLIEKITQ-YPTPV 311

Query: 299 SDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHV------PAVPAAITV 352
              FLL   K    +++ +SGF GG   P + +G  LG +    +        +     +
Sbjct: 312 LILFLLLAGKFLYTLISYSSGFPGGIFLPMLVIGALLGKIYGIFIVNLFGVSDIYITHYI 371

Query: 353 SCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL 398
              +      V R     + +   +  N + L  L  +   ++++ 
Sbjct: 372 ILGMAAYFTAVVRAPITGIILILEMTGNFSHLFALTFISAVSYIIT 417


>UniRef50_Q04PD3 Chloride channel protein n=4 Tax=Leptospira RepID=Q04PD3_LEPBJ
          Length = 626

 Score =  231 bits (590), Expect = 3e-59,   Method: Composition-based stats.
 Identities = 69/463 (14%), Positives = 142/463 (30%), Gaps = 56/463 (12%)

Query: 5   RARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQD---------- 54
           R      L    +  GI S L   +  +I +V + L   R  G                 
Sbjct: 10  RISGRRSLYFYCILTGIVSGLGAFLFSRILAVCEYLFLDRAAGLSLPHASGEFLIDSNDT 69

Query: 55  -----------SPLWIIGVLTLTGIAVGLVI-RFSQGHAGPDPACE----PLIGAPVPPS 98
                       P  +  +  + G+  G ++ RFS    G                + P 
Sbjct: 70  LHWGIPFSDEYRPWVLFFLPIIGGLLTGWIVNRFSPESGGTGSDAMIDSFHNQEGRMNPV 129

Query: 99  ALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARLLPRVN-RMEWTILASAGTIG 157
                 +A +  LA G S G E PI  +       +   L      R    +  +AG +G
Sbjct: 130 VSLVKSIATVFTLASGGSGGKEGPISQIGAGFGSLLATLLKAGARARRTLLLAGTAGGLG 189

Query: 158 ALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQ 217
           A+F  P+  AL   + +         D L   ++++ +  L        +    +     
Sbjct: 190 AIFHAPLGGALTSVEMIYREDIE--SDSLIPCIISSVSAYLVYSGLNGFNTVYRVTGTEF 247

Query: 218 MEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGP 277
           +  TD++    +  +    G + +    ++      +K   ++    G I   +  +  P
Sbjct: 248 LRYTDLIFYLGLGVLCFLCGDIFIRIFRKVQNFSAHLKISPILKPALGGIFVGIVGLFLP 307

Query: 278 VSLFKGLDEMQQMVAN-----------------QAFSTSDYFLLAVIKLAALVVAAASGF 320
            ++  G   +Q  +                     +  + +F+LA +K+        +G 
Sbjct: 308 ETIGTGAGILQVALDGKDPVGASGIFSSVFQSSGLWLVALFFILAGVKILTTSFTVGTGG 367

Query: 321 RGGRIFPAVFV-------GVALGLMLHEHVPAVPAAITVSCAILGIVLVVTRDGWLSLFM 373
             G   P++F+             +     P +     +   +      V       + M
Sbjct: 368 SAGMFGPSLFIGGMLGGGVGTFAKIF--VYPDLSVTSFILVGMGAFYAGVASAPIAGMIM 425

Query: 374 AAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNRP-KQQPPH 415
              ++ +  LLP L +V +  ++L     +    +  + Q P 
Sbjct: 426 ICEMIGSYMLLPPLMVVSILTFVLSHKLSLYRAQKETRFQSPA 468


>UniRef50_C5NXG2 H(+)/Cl(-) exchange transporter ClcA n=1 Tax=Gemella haemolysans
           ATCC 10379 RepID=C5NXG2_9BACL
          Length = 507

 Score =  231 bits (589), Expect = 5e-59,   Method: Composition-based stats.
 Identities = 59/400 (14%), Positives = 129/400 (32%), Gaps = 8/400 (2%)

Query: 7   RTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLT 66
           +    L    + +G+ + ++      +    + L+                 +  ++ L 
Sbjct: 15  KLETSLLFDGILVGLFAGIVGASYRLLIGYSEKLVHYTAEFIKNGFIYKIFLLGALILLA 74

Query: 67  GIAVGLVIRFSQGHAGPDPACEPLIGAPV---PPSALPGLIVALILGLAGGVSLGPEHPI 123
             +  L+ R         P     I   +   P   L   I   +    GG+SLG E P 
Sbjct: 75  LFSGFLLKREPMASGSGIPQVSAEITGRLNPNPLRILIYKITGGLTASLGGLSLGREGPS 134

Query: 124 MTVNIALAVAIGARLLPRV-NRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPL 182
           + +       +   L   +     +    ++  +   FG P+A  L   + ++       
Sbjct: 135 IQLGAMSGKLVSRILKKDIIKEKYFITCGASAGLSIAFGAPLAGVLFSIEEVHKQITK-- 192

Query: 183 WDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVW 242
              +     AA    +     F             +E++     A++  +    G     
Sbjct: 193 -KIIICCFSAAVVANIVGQYIFGLTAIFKFPDIPYVEVSIYPWVALLGILLGIFGTFYNI 251

Query: 243 CLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYF 302
            +  L  +   +K  ++      F++  +  I  P+ L  G + ++ ++ N+ FS     
Sbjct: 252 TIKILFRIYEFLKLNIVFRPQIAFLISFVLFIFYPIVLGSGHNLVEFLIENK-FSFMFLL 310

Query: 303 LLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLV 362
            L  IK    +++  SG  GG   P +  G  LG +      A   A+ V  ++ G +  
Sbjct: 311 TLYFIKTLFSLISFTSGVAGGIFLPILIQGAILGTLFSNFFDAKYTALFVILSMSGYLTA 370

Query: 363 VTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKP 402
           + R    S+ +   +         + +  L A++      
Sbjct: 371 IVRSPITSIILLFEMTQKLNYFLPIALCCLFAYMTANILG 410


>UniRef50_Q8RXR2 Chloride channel protein CLC-f n=18 Tax=Magnoliophyta
           RepID=CLCF_ARATH
          Length = 781

 Score =  230 bits (588), Expect = 6e-59,   Method: Composition-based stats.
 Identities = 63/420 (15%), Positives = 126/420 (30%), Gaps = 34/420 (8%)

Query: 10  LLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPG------TLGIAQDSPLWIIGVL 63
             L L    IG+A+ + +    K   V+    W   P        L    D+   I+ + 
Sbjct: 129 WALLLIGCLIGVAAGICVAGFNKGVHVIHEWAWAGTPNEGAAWLRLQRLADTWHRILLIP 188

Query: 64  TLTGIAVGLVIRFSQGHAGPDPACEPLIGAPVPPSAL---PGLIVALILGLAGGVSLGPE 120
              G+ VG++                     +   A        +   + L  G SLGPE
Sbjct: 189 VTGGVIVGMMHGLL-EILDQIRQSNSSQRQGLDFLAGIYPVIKAIQAAVTLGTGCSLGPE 247

Query: 121 HPIMTVNIALAVAIGARLLPRVNRME-WTILASAGTIGALFGTPVAAALIFSQTLNGSSE 179
            P + +  + A      +     R    T   +A  I + F   VA      +T+     
Sbjct: 248 GPSVDIGKSCANGFALMMENNRERRIALTAAGAASGIASGFNAAVAGCFFAIETVLRPLR 307

Query: 180 VPLWDRLFAP--LMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAG 237
                       ++A+   +  +        +  +  Y      ++    I+  +  A  
Sbjct: 308 AENSPPFTTAMIILASVISSTVSNALLGTQSAFTVPSYDLKSAAELPLYLILGMLCGAVS 367

Query: 238 MVAVWCLPRLHAMMH----QMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVAN 293
           +V    +            +   P +V    G +   +  +  P  L+ G   +++++  
Sbjct: 368 VVFSRLVTWFTKSFDFIKDKFGLPAIVCPALGGLGAGIIALKYPGILYWGFTNVEEILHT 427

Query: 294 Q----AFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAV--- 346
                A        LA  K+ A  +   SG  GG   P++ +G A+G +       +   
Sbjct: 428 GKSASAPGIWLLAQLAAAKVVATALCKGSGLVGGLYAPSLMIGAAVGAVFGGSAAEIINR 487

Query: 347 ---------PAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLC-IVMLPAWL 396
                             +   +  +      S+ +   +  +  +L  L   V L  W+
Sbjct: 488 AIPGNAAVAQPQAYALVGMAATLASMCSVPLTSVLLLFELTKDYRILLPLMGAVGLAIWV 547


>UniRef50_C7R845 Chloride channel core n=1 Tax=Kangiella koreensis DSM 16069
           RepID=C7R845_KANKD
          Length = 591

 Score =  229 bits (584), Expect = 2e-58,   Method: Composition-based stats.
 Identities = 70/404 (17%), Positives = 138/404 (34%), Gaps = 19/404 (4%)

Query: 11  LLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAV 70
           L++L  +  G+ +    I+          L                L+ + + T+ G+ V
Sbjct: 19  LMALIGLICGLLAGGSNILFRLFTESSLVLWATDPNSNTDYETMDWLYRLLLPTIGGLIV 78

Query: 71  GLVIRFSQG-----HAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMT 125
           GL+++  +                     +PP       +   L +A G S+G E P + 
Sbjct: 79  GLLLQQLKPEHRQVGVSHVLERMSYHQGHLPPQNAFVQFILGGLTIASGQSVGREGPGIH 138

Query: 126 VNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWD 184
           +  A A  +G +L LP  +         A  I A F TP+A  +   + +     V    
Sbjct: 139 LGSASASWVGQKLKLPNNSTRILVGCGCAAAISANFNTPLAGVIFAMEIIIMEYAVA--- 195

Query: 185 RLFAPLMAAAAGALTTGLFFHPHFSLPIAH-YGQMEMTDILSGAIVAAIAIAAGMVAVWC 243
                ++A+ AGA+ T L F    S  +        + ++    +V         V +  
Sbjct: 196 SFIPIILASVAGAILTRLVFGDGASFDVPSKLDIQSLWEMPYFLLVGFAGGVFASVFIMA 255

Query: 244 LPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFL 303
             ++  +  +   PV +          +  IG P  +  G D +   +  +   T    L
Sbjct: 256 TRKVRQISREW--PVWLKTTVAGTSVGIIAIGIPQVMGIGYDSVNGALQGELALTIL-AL 312

Query: 304 LAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPA------AITVSCAIL 357
             V KL A ++ +     GG I PA+F+G  LG ++      +               + 
Sbjct: 313 ALVGKLIATIICSGLSLPGGVIGPALFMGAMLGGVMGNIGGELFPDQASYTGFYAMIGMA 372

Query: 358 GIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGK 401
            ++  V +    +L     +  N  ++      ++   L++   
Sbjct: 373 TVMGAVLQAPLAALMALLELTNNPNIIFPGMFSIVIGNLVVTQL 416


>UniRef50_UPI0001BC5534 chloride channel protein n=3 Tax=Fusobacterium RepID=UPI0001BC5534
          Length = 526

 Score =  228 bits (582), Expect = 3e-58,   Method: Composition-based stats.
 Identities = 61/410 (14%), Positives = 132/410 (32%), Gaps = 19/410 (4%)

Query: 11  LLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAV 70
            L    + +G+ + +I+        +   L    +           + +     + G  +
Sbjct: 21  KLYFLCLMVGLITGIIVSFYRYALHIFNVLRETFVSPNTLTNYPFLIKLWIGFLVIGFFI 80

Query: 71  GLVIRFSQGHAGP-DPACEPLIGAPVPPS----ALPGLIVALILGLAGGVSLGPEHPIMT 125
             + R     +G   P  + +I   V        L    V  + G+  G+SLG E P + 
Sbjct: 81  DFLYRKYPRTSGSGIPQVKGIILGTVHYKHWFAQLVAKFVGGLFGIGAGLSLGREGPSVQ 140

Query: 126 VNIALAVAIGARLL-PRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWD 184
           +   +A  I       RV+        ++  +   FG P+A  +   + L+      L  
Sbjct: 141 LGSYVASGIAKGFRCNRVDENYLITSGASAGLAGAFGAPLAGVMFSLEELHKFLTAKL-- 198

Query: 185 RLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDIL---SGAIVAAIAIAAGMVAV 241
            +    +A+ A       FF    +  +      ++   L      +   +    G +  
Sbjct: 199 -IICIFVASIASDFIGRRFFGIDTAFSMLVSYPRDINPYLQFALYILFGILIAFFGKLFT 257

Query: 242 WCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDY 301
             L +   +   ++    +  +       L  +  P     G + ++ +   Q       
Sbjct: 258 TTLVKTQNIFQGIRISRWMKVVFVMSTSFLLCLVLPEVTGGGHELVESLPQLQQ-GILFL 316

Query: 302 FLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPA------AITVSCA 355
           F + +IKL    ++ A+GF GG   P + +G  LG +    +              +   
Sbjct: 317 FFVFLIKLLFTSLSYATGFAGGIFLPMLVLGAILGKIFALLLLHFFPFDPNIIVHFMVLG 376

Query: 356 ILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMM 405
           ++G  + V R       +   +  +   L  L  V + A+ + A   +  
Sbjct: 377 MVGYFVSVVRAPITGAVLILEMTGSFDHLLALVTVSVVAFYVTALLKLAP 426


>UniRef50_Q8GX93 Chloride channel protein CLC-e n=7 Tax=Magnoliophyta
           RepID=CLCE_ARATH
          Length = 710

 Score =  227 bits (579), Expect = 6e-58,   Method: Composition-based stats.
 Identities = 59/436 (13%), Positives = 143/436 (32%), Gaps = 35/436 (8%)

Query: 13  SLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGT------LGIAQDSPLWIIGVLTLT 66
              A  +G+ + + +++      +L++  W  +P              + L +I V T+ 
Sbjct: 77  IASACLVGVLTGVSVVLFNNCVHLLRDFSWDGIPDRGASWLREAPIGSNWLRVILVPTIG 136

Query: 67  GIAVGLVIRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTV 126
           G+ V ++ +  +            +             VA  + L  G SLGPE P + +
Sbjct: 137 GLVVSILNQLRESAGKSTGDSHSSLDRVKAVLRPFLKTVAACVTLGTGNSLGPEGPSVEI 196

Query: 127 NIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDR 185
             ++A  + +                SA  I + F   VA      +++   S       
Sbjct: 197 GASIAKGVNSLFNKSPQTGFSLLAAGSAAGISSGFNAAVAGCFFAVESVLWPSSSTDSST 256

Query: 186 LFA-----PLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVA 240
                    +++A   ++ + +      +  +  Y      ++    ++ A+     +  
Sbjct: 257 SLPNTTSMVILSAVTASVVSEIGLGSEPAFKVPDYDFRSPGELPLYLLLGALCGLVSLAL 316

Query: 241 VWCLPRLHAMMHQMKN----PVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAF 296
             C   + + +  +      P  V  + G +   +  +  P  L+ G   +  ++  + F
Sbjct: 317 SRCTSSMTSAVDSLNKDAGIPKAVFPVMGGLSVGIIALVYPEVLYWGFQNVDILLEKRPF 376

Query: 297 ----STSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPA------- 345
               S      L  +K+AA     ASG  GG   P++F+G A G+   + +         
Sbjct: 377 VKGLSADLLLQLVAVKIAATAWCRASGLVGGYYAPSLFIGGAAGMAYGKFIGLALAQNPD 436

Query: 346 --------VPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLL 397
                             +   +  V +    ++ +   +  +  ++  L   +  +  +
Sbjct: 437 FNLSILEVASPQAYGLVGMAATLAGVCQVPLTAVLLLFELTQDYRIVLPLLGAVGMSSWI 496

Query: 398 LAGKPMMMVNRPKQQP 413
            +G+      R  ++ 
Sbjct: 497 TSGQSKRQETRETKET 512


>UniRef50_B2J2P8 Cl-channel, voltage-gated family protein n=3 Tax=Cyanobacteria
           RepID=B2J2P8_NOSP7
          Length = 863

 Score =  227 bits (579), Expect = 6e-58,   Method: Composition-based stats.
 Identities = 70/409 (17%), Positives = 152/409 (37%), Gaps = 22/409 (5%)

Query: 7   RTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLT 66
           R   L  + A  IG+ S L  +++ +                L     + L + G+  + 
Sbjct: 18  RPRRLAFVEACIIGLVSGLAAVLLGQAVDWAGAWRVH-----LSYIWPAYLVLPGIGLVG 72

Query: 67  GIAVGLVI-RFSQGHAGPDP----ACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEH 121
           GI  G ++ RF+   +G       A    +  P+        +V+  L L  G+ LG E 
Sbjct: 73  GILAGWLVERFAPEASGSGMSEVKAVLARVPMPLNLRIALVKLVSATLVLGSGMPLGREG 132

Query: 122 PIMTVNIALAVAIGARLL-PRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSE- 179
           P + +  ALA  +   +     +R +     +   + A F  P+A  L   + L      
Sbjct: 133 PTVQIGAALANQLSNWVPTSPEHRRQLIAAGAGAGLAAAFNAPIAGVLFVVEELLQDVSG 192

Query: 180 VPLWDRLFAPLMAAAAGALT-TGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGM 238
           + L   + A  +A+    L  +      H  L  +H       +I    I+  +    G+
Sbjct: 193 ITLGTAILASFIASVISRLYGSHSLDLNHLDLSFSHTTFF-AQEIPFYLILGVLGGLIGI 251

Query: 239 VAVWCLPRLHAMMHQMKN--PVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAF 296
           +    +    A+  ++ N      +GI G + G+   +      F+    +++++   + 
Sbjct: 252 LFNKSILASLAINRRLLNLSLPWRIGIVGLVTGVAIALL--PITFRNNAGLREILLVGSG 309

Query: 297 STSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHE----HVPAVPAAITV 352
           +     +  +++   +++   SG  GG + P + +G ALG ++       +    A    
Sbjct: 310 NWLFAAIALLVQFTLIILTYGSGAPGGLLVPTLVLGAALGYLVGAAEQSLLGMSAATTYA 369

Query: 353 SCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGK 401
              +  +   V++    ++ +   +  +  L+  L IV + A+L+    
Sbjct: 370 HVGMAALFSAVSKVPITAVVIVFEMTTDFNLVLPLMIVSVIAYLVAEKI 418



 Score = 50.2 bits (119), Expect = 2e-04,   Method: Composition-based stats.
 Identities = 28/194 (14%), Positives = 65/194 (33%), Gaps = 11/194 (5%)

Query: 223 ILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMK--NPVLVLGIGGFILGILGVIGG---- 276
            +   I+  ++  A ++    +    A    +    P  ++  G  ++G +         
Sbjct: 24  FVEACIIGLVSGLAAVLLGQAVDWAGAWRVHLSYIWPAYLVLPGIGLVGGILAGWLVERF 83

Query: 277 -PVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVAL 335
            P +   G+ E++ ++A      +    +A++KL +  +   SG   GR  P V +G AL
Sbjct: 84  APEASGSGMSEVKAVLARVPMPLN--LRIALVKLVSATLVLGSGMPLGREGPTVQIGAAL 141

Query: 336 GLMLHEHVPAVPAA--ITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLP 393
              L   VP  P      ++      +          +      +        L   +L 
Sbjct: 142 ANQLSNWVPTSPEHRRQLIAAGAGAGLAAAFNAPIAGVLFVVEELLQDVSGITLGTAILA 201

Query: 394 AWLLLAGKPMMMVN 407
           +++      +   +
Sbjct: 202 SFIASVISRLYGSH 215


>UniRef50_A2ZX03 Putative uncharacterized protein n=2 Tax=Oryza sativa
           RepID=A2ZX03_ORYSJ
          Length = 718

 Score =  227 bits (579), Expect = 7e-58,   Method: Composition-based stats.
 Identities = 66/439 (15%), Positives = 146/439 (33%), Gaps = 37/439 (8%)

Query: 11  LLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLP--GTLGIAQDS----PLWIIGVLT 64
           L++L A  +G+ S + +++       +++L W  +P  G   + ++S       +I V  
Sbjct: 79  LVTLAACLVGLLSGVSVVLFNLSVHEIRDLFWDGIPLRGASWLREESIGEIWQRVILVPV 138

Query: 65  LTGIAVGLVIRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIM 124
             GI VG+        A         I     P       +A    L  G SLGPE P +
Sbjct: 139 SGGIIVGVFNTLRSSIATNSNDTMSKIKGAFRP---FLKAMAASFTLGTGNSLGPEGPSV 195

Query: 125 TVNIALAVAIGARLLPRVNRME-WTILASAGTIGALFGTPVAAALIFSQTLN---GSSEV 180
            +  ++A   G        +        SA  I + F   VA      +++         
Sbjct: 196 EIGSSIAKGFGNVFKLEGGKKLSLVAAGSAAGIASGFNAAVAGCFFAVESVLWPTSVDSS 255

Query: 181 PLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVA 240
            L +     +++A   ++ + +      +  +  Y     T++    ++           
Sbjct: 256 SLSNSTPMVILSAVIASVVSEIGLGSDPAFTVPEYDFRSPTELPLYLLLGIFCGLVSTTL 315

Query: 241 VWCLPRLHAMMHQMK----NPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAF 296
             C      ++  ++     P       G ++  L  +  P  L+ G + +  ++ ++ F
Sbjct: 316 SRCTALSMEIVQSLQTATGLPKAASPALGGLIVGLLALVYPEVLYWGFENVDILLESRPF 375

Query: 297 STSDYFLLAV----IKLAALVVAAASGFRGGRIFPAVFVGVALGLMLH------------ 340
           ++     + V    +K+ A  +  A G  GG   P++F+G A G+               
Sbjct: 376 TSGLSAAVLVQLIGVKVLATSLCRAFGLVGGYYAPSLFIGAATGMAYGKVMRFTFTGPDS 435

Query: 341 ----EHVPAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWL 396
                 +            +   +  V +    S+ +   +  +  ++  L   +  +  
Sbjct: 436 LFQIPFLDVASPQAYGLVGMAATLAGVCKVPLTSVLLLFELTQDYRIVLPLLGAVGVSSW 495

Query: 397 LLAGKPMMMVNRPKQQPPH 415
           + + +     NR K     
Sbjct: 496 IASPQRFSRSNRSKPDSSE 514


>UniRef50_C6C168 Chloride channel core n=1 Tax=Desulfovibrio salexigens DSM 2638
           RepID=C6C168_DESAD
          Length = 590

 Score =  225 bits (575), Expect = 2e-57,   Method: Composition-based stats.
 Identities = 67/426 (15%), Positives = 152/426 (35%), Gaps = 21/426 (4%)

Query: 2   LHPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIG 61
            +PR + +LL+S  +VAIG+A++    +   +    Q+  W      L +A +SP W++ 
Sbjct: 17  FNPRVQYVLLMSF-SVAIGMAAAGGAFLFRWLIENFQHFFWASGNSFLDMAANSPWWLVL 75

Query: 62  VLT-LTGIAVGLVIRFS-----QGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGV 115
            L  + G+  G++I                    + G  +         +A  L +  G 
Sbjct: 76  FLPCIGGLIAGVIITNWAPEAQGPGVPEVIKALAVRGGVIRHRITFLKALATSLLIGCGA 135

Query: 116 SLGPEHPIMTVNIALAVAIGARLLPRVNRMEW-TILASAGTIGALFGTPVAAALIFSQTL 174
           S+G E P++ +  +L  +         + +       +A  I A F  P+   L   + L
Sbjct: 136 SVGREGPVVQIGASLGSSAARIFRLDPSMLPVCVASGAAAGIAATFNAPLTGTLFAIEIL 195

Query: 175 NGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAI 234
              +E+         ++A+   +  +  F+    +     +      +++   ++  +A 
Sbjct: 196 LLDTEMSYVSH---IIVASVTASALSKFFWGDFPTFDAPKFIFSNFEELIIFFLLGILAG 252

Query: 235 AAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQ 294
              +  V  +        Q+  P  V    G ++     +  P  L  G + +   +   
Sbjct: 253 LVSIAFVKMIRLCEFTFDQIPVPGWVKPGLGGLILGAIALKIPAVLGVGYEAVNMGLTG- 311

Query: 295 AFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAI---- 350
                   +L   KL A  +   SG  GG   P++ +G ALG+ +   +  +   +    
Sbjct: 312 VLPLDLAIILLGAKLVATSLCIGSGMSGGIFAPSLVLGAALGVSVSSTINMIFPELALTH 371

Query: 351 --TVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLA---GKPMMM 405
                  +  +V   T     ++     +  +  ++  + +  + + L++    G  +  
Sbjct: 372 GQYALVGMGTVVAGTTLAPITAVLTVFELTYSYKIILPMMVGCITSALVVRILKGYSVYE 431

Query: 406 VNRPKQ 411
               +Q
Sbjct: 432 AKLLRQ 437


>UniRef50_C6PDT2 Chloride channel core n=1 Tax=Thermoanaerobacterium
           thermosaccharolyticum DSM 571 RepID=C6PDT2_CLOTS
          Length = 521

 Score =  225 bits (575), Expect = 2e-57,   Method: Composition-based stats.
 Identities = 53/396 (13%), Positives = 129/396 (32%), Gaps = 17/396 (4%)

Query: 28  IVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRFSQGHAGPDPAC 87
            ++  I       L              P+W++ ++ L      ++           P  
Sbjct: 37  SILRLILEKAGMYLLILYKALETKIYLLPIWLVFLVALGIFTNYILKLEPMISGSGIPQV 96

Query: 88  EPLIGAPVPP---SALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARL-LPRVN 143
           E  I                V  IL +  G+SLG E P + +  +L   +   L   R  
Sbjct: 97  EGTIIGYFKLNWLKIFVLKFVGTILMIGAGLSLGREGPCVQLGASLGQGVSRSLKRMRFE 156

Query: 144 RMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLF 203
                   +   + A F  P+A  +   + L+ +        L + ++++      T  F
Sbjct: 157 EKYLITCGAGAGLAAAFNAPLAGVIFSLEELHKNFSP---IVLVSSMVSSLTATYITDTF 213

Query: 204 FHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGI 263
                   I +   +  +  +   ++  +    G++    L +   + ++      +   
Sbjct: 214 LGLKTVFDITNLPIVPFSKYIYLLVLGVVIGLGGILFNKSLLKSQDLYNKYVKIPQLKIF 273

Query: 264 GGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGG 323
              ++ ++  +  P+ L  G   + ++ ++     +   LL + K    +V+  SG  GG
Sbjct: 274 IPLLVSVIVGLSIPMVLGGGESLVDKI-SSVNLGFAFVILLLISKFLFTMVSYGSGVPGG 332

Query: 324 RIFPAVFVGVALGLMLH------EHVPAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVV 377
              P + +G  +G +         ++  +     +  A+ G    + R       +   +
Sbjct: 333 IFMPLLAIGALIGNLYGIIIIHIFNIDQLYLKDFIVLAMAGYFAAIVRAPITGSLLVTEM 392

Query: 378 VPNTTLLPLLCIVMLPAWLLLA---GKPMMMVNRPK 410
             + + L  L  V + A+++       P+      +
Sbjct: 393 TGSFSHLLALSTVSITAYIVSGLYRNMPIYESLLDR 428


>UniRef50_Q21MI5 Cl-channel, voltage gated n=1 Tax=Saccharophagus degradans 2-40
           RepID=Q21MI5_SACD2
          Length = 585

 Score =  225 bits (575), Expect = 2e-57,   Method: Composition-based stats.
 Identities = 64/407 (15%), Positives = 132/407 (32%), Gaps = 17/407 (4%)

Query: 22  ASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGV---LTLTGIAVGLVIRFSQ 78
            + +I+++   +  +  +      P          +W++ +   + +  +      + SQ
Sbjct: 36  FTGVIIVIFRLLIDLPLSYFLDTRPDNFEAMPTDMIWLLIMGGTIPIAILLHFAGKKRSQ 95

Query: 79  GHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARL 138
                           +P S          L +  G S+G E P + +   +A  +G  L
Sbjct: 96  TGVSHVIDRLHNYQGQLPTSNWMVQFFGAALCMLSGQSVGREGPAVHLGAGVASKLGKWL 155

Query: 139 -LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGA 197
            LP  + +       A  I A F TP+A  +   + +     V         ++A+  G 
Sbjct: 156 NLPNNSLLTLIACGVAAGISASFDTPMAGVIFAMEVVVLEYTV---VGFVPVILASVMGT 212

Query: 198 LTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNP 257
           + + L F    +  I       + ++    ++           +        +    K P
Sbjct: 213 MVSQLVFGEASNFKIGPVDMGSLLELPYMIVMGLAISVCAAAYIKLNLGAMRLS---KYP 269

Query: 258 VLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAA 317
           V +  I   +L      G P  +  G D +  ++  +    S   ++ V KL    V   
Sbjct: 270 VALRVIVAGLLTATIASGVPEVMGLGYDTVNAIIVGEVLLFS-LLIIGVAKLFLTPVVIG 328

Query: 318 SGFRGGRIFPAVFVGVALGLMLHEHVPAVPA------AITVSCAILGIVLVVTRDGWLSL 371
            G  GG I P + VG  LG +L     AV           V   + G++         +L
Sbjct: 329 LGMPGGVIGPLLVVGACLGGVLGTFFDAVFPNLGASPGFYVVLGMAGMMAATLNAPLAAL 388

Query: 372 FMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNRPKQQPPHDNV 418
                +  N  ++    +V++ + L       +     +Q    + +
Sbjct: 389 VAVLELSYNPNMIFPAMLVIVVSCLSTRQLFSLDSIFTEQLRLTNRL 435


>UniRef50_A8UVV7 tRNA (Uracil-5-)-methyltransferase Gid n=3 Tax=Aquificaceae
           RepID=A8UVV7_9AQUI
          Length = 569

 Score =  225 bits (573), Expect = 3e-57,   Method: Composition-based stats.
 Identities = 66/431 (15%), Positives = 141/431 (32%), Gaps = 28/431 (6%)

Query: 11  LLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPG-------------TLGIAQDSPL 57
              L  + IG+ + L  ++ +     L + + + + G                   + P 
Sbjct: 4   RYLLLPITIGVLTGLFAVLFVHALEFLTHYVLELVVGYLQPLPAGEGTREHFSSYPERPY 63

Query: 58  WIIGVLTLTGIAVGLVIRFSQ---GHAGPDPACEPLI-GAPVPPSALPGLIVALILGLAG 113
            +   + L G+  GL+  F        G D A         +   +    +V   + +  
Sbjct: 64  LLPLTVALGGLVSGLLAHFLSPESAGVGTDAAIRAYHNKDRLSIKSSVVKLVTSAITIGT 123

Query: 114 GVSLGPEHPIMTVNIALAVAIGARLL-PRVNRMEWTILASAGTIGALFGTPVAAALIFSQ 172
           G + G E PI  +   +   +G         R     +     I A+F  P+A A+I ++
Sbjct: 124 GGTSGREGPIALIGAGVGSTVGELFRLNSKERRTALAVGLGAGIAAIFKAPLAGAIISAE 183

Query: 173 TLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFH--PHFSLPIAHYGQMEMTDILSGAIVA 230
                      + +    +A+       GLFF   P FS  I     ++   +L+ A + 
Sbjct: 184 VFFRRDFE--IEAMIPGFIASVTSYSIFGLFFGFQPIFSAEIPKLLNVQPFSLLAYAGLG 241

Query: 231 AIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQM 290
            +      V  +   ++     + + P  +    G  +  L     PV++  G   +Q +
Sbjct: 242 FVCAIVVRVFTFVFFKVKEEFDKPRLPTYLKPALGGFVAGLIGAFVPVAIGNGYGWLQLI 301

Query: 291 VANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPA----- 345
           +  +    +   L A+  +  +     SG  GG   P+V +G  +G      +       
Sbjct: 302 LDGKLNDLTFIVLGALAVMLGVSFTLGSGMSGGVFGPSVMIGGLVGAAYSLALNQHYSLS 361

Query: 346 VPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMM 405
           +         ++ +     +    +L + A +     LL    + +  ++ L   K +  
Sbjct: 362 LHVPSFTIVGMVSLFAGAAKAPLSTLILIAEMTGGYELLVPAMVSVFISYFLSGKKSIFP 421

Query: 406 VNRP-KQQPPH 415
                +   P 
Sbjct: 422 SQVDTRLDSPA 432


>UniRef50_D1RX40 Chloride channel protein n=1 Tax=Serratia odorifera 4Rx13
           RepID=D1RX40_SEROD
          Length = 517

 Score =  225 bits (573), Expect = 3e-57,   Method: Composition-based stats.
 Identities = 73/429 (17%), Positives = 143/429 (33%), Gaps = 28/429 (6%)

Query: 5   RARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLT 64
           R +T + +   A  +G  + L+ +   K    +Q      L           +W +  + 
Sbjct: 66  RDKTPVAILFMAAVVGTLAGLLGVAFDKAVDWVQQQRLSALAQVA--DSWILVWPLAFIL 123

Query: 65  LTGIAV---GLVIRFSQGHAGP-DPACEPLIGAPVP---PSALPGLIVALILGLAGGVSL 117
              +AV    LV RF+    G   P  E  +    P      +P   +  +  L  G+ L
Sbjct: 124 SAALAVLGYYLVRRFAPEAGGSGIPEIEGALEELRPVRWWRVIPVKFIGGMGTLGAGMVL 183

Query: 118 GPEHPIMTVNIALAVAIGARLLPR--VNRMEWTILASAGTIGALFGTPVAAALIFSQTLN 175
           G E P + +   +   +      R    R       +A  + A F  P+A  L   + + 
Sbjct: 184 GREGPTVQMGGNVGRMVLDIFRMRGAEARHSLLATGAAAGLSAAFNAPLAGILFIIEEMR 243

Query: 176 GSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIA 235
                 L   + A  +     ++   LF   H  + +       +  +    ++ A+  A
Sbjct: 244 PQFRYNL-ISIKAVFIGVIMSSVVFQLFNGEHSVIEVGKLSSAPINTLWLYLVLGAVFGA 302

Query: 236 AGMVAVWCLPRLHAMMHQM-----KNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQM 290
            G++    + R   M  +      +N +++ G+ G   GILG+I  P +   G   +   
Sbjct: 303 VGVMFNALIFRTQDMFARFHGGKMRNILMIGGLIGGTCGILGLI-QPQAAGGGFGLIPIA 361

Query: 291 VANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPA-- 348
            A   +S      + + ++   ++   SG  GG   P + +G   G         +    
Sbjct: 362 AAGN-YSVGMLLFIFIARVITTLLCFGSGAPGGIFAPMLALGTLFGTAFGLAGAHLFPQY 420

Query: 349 ----AITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL---AGK 401
                      +  +     R     + +   +  N  L+  + I  L A L+     GK
Sbjct: 421 GIEAGTFAIAGMGALFAATVRAPLTGIVLVLEMTDNYQLILPMIITCLGATLVAQFLGGK 480

Query: 402 PMMMVNRPK 410
           P+      +
Sbjct: 481 PLYSSILAR 489


>UniRef50_Q3AQR7 Chloride channel, putative n=12 Tax=Chlorobiaceae
           RepID=Q3AQR7_CHLCH
          Length = 631

 Score =  225 bits (573), Expect = 4e-57,   Method: Composition-based stats.
 Identities = 58/409 (14%), Positives = 133/409 (32%), Gaps = 23/409 (5%)

Query: 10  LLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVL---TLT 66
           +     AV +G+ +  + ++  +    + N  +  L     I+     W+  +     + 
Sbjct: 54  IPFLFVAVIVGLVTGYVAVLFHEAIKAISNFSFNDLRLLGDISFIEQYWVFFLPFIPAIG 113

Query: 67  GIAVGLVIRF-----SQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEH 121
           G+ VGL   F     S+                +         +  ++ +  G   G E 
Sbjct: 114 GLFVGLYNTFIIKKSSRHALASVIKSVAHNDGIIDRKLWFHKTITSVVCIGTGGGGGREA 173

Query: 122 PIMTVNIALAVAIGARLL-PRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEV 180
           PI+ V  A+   I   L              +A  + A+F  P+ A +   + L G   V
Sbjct: 174 PIVQVGSAIGSTIAQWLRFSPEKTRTLLGCGAAAGLAAVFNAPIGAVMFAIEVLLGDFSV 233

Query: 181 PLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVA 240
                    ++AA  G + +  F     +  +  Y  +   ++L   ++  +A  + ++ 
Sbjct: 234 ---KTFSPIVIAAVIGTVLSRSFLGNRPTFDVPDYTLVSNIELLFYCVLGVLAGLSAVMF 290

Query: 241 VWCLPRLHAMMHQMKN----PVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAF 296
           +     +     +++     PV ++   G  L  +  I  P       + +   V     
Sbjct: 291 IKTYFAIEEWFDKLQIRRNLPVWIMPAIGGFLSGIICIWLPGLYGFSYNVISNAVYGNE- 349

Query: 297 STSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPA------AI 350
           +  +   + ++K     ++  SG  GG   PA+ +G  LG M    V             
Sbjct: 350 TWYNLIGIYLLKPVVAGLSIGSGGAGGMFAPAMKMGAMLGGMFGIVVHQFFPLITATSGA 409

Query: 351 TVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLA 399
                +  +   V R     + +   +     ++  +    + + ++  
Sbjct: 410 YALVGMGALTAGVMRAPLTVILILFEITGQYEIVLPIMFAAVTSAVVAR 458



 Score = 60.6 bits (146), Expect = 9e-08,   Method: Composition-based stats.
 Identities = 30/205 (14%), Positives = 63/205 (30%), Gaps = 24/205 (11%)

Query: 8   TMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTG 67
           + + L    V  G+ + L  ++ +K    ++          L I ++ P+WI  +  + G
Sbjct: 269 SNIELLFYCVL-GVLAGLSAVMFIKTYFAIEEWF-----DKLQIRRNLPVWI--MPAIGG 320

Query: 68  IAVGLVIRFSQGHAG-PDPACEPLIGAPVPPSAL----PGLIVALILGLAGGVSLGPEHP 122
              G++  +  G  G         +        L        V   L +  G + G   P
Sbjct: 321 FLSGIICIWLPGLYGFSYNVISNAVYGNETWYNLIGIYLLKPVVAGLSIGSGGAGGMFAP 380

Query: 123 IMTVNIALAVAIGARLLP-----RVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGS 177
            M +   L    G  +             + ++        +   P+   LI  +     
Sbjct: 381 AMKMGAMLGGMFGIVVHQFFPLITATSGAYALVGMGALTAGVMRAPLTVILILFEITGQ- 439

Query: 178 SEVPLWDRLFAPLMAAAAGALTTGL 202
                ++ +   + AA   A+   L
Sbjct: 440 -----YEIVLPIMFAAVTSAVVARL 459


>UniRef50_Q2JA24 Cl-channel, voltage gated n=4 Tax=Actinomycetales
           RepID=Q2JA24_FRASC
          Length = 626

 Score =  224 bits (572), Expect = 4e-57,   Method: Composition-based stats.
 Identities = 65/404 (16%), Positives = 137/404 (33%), Gaps = 24/404 (5%)

Query: 19  IGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSP-------LWIIGVLTLTGIAVG 71
           IG    L  +    + ++   +   R   ++G    +P        +++ V  + G+  G
Sbjct: 34  IGAGVGLGAVAFRGLINLFTEVFCGRADCSVGGRLPNPHIPDLGFWFLLAVPVIGGLVYG 93

Query: 72  -LVIRFSQGHAGP----DPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTV 126
            L+ RF++   G       +        + P       +A  L +  G S+G E PI+ +
Sbjct: 94  PLIHRFAREARGHGVPEVMSAVAERDGRISPRVSAVKSLASALCIGAGGSVGREGPIVQI 153

Query: 127 NIALAVAIGARLLPRVNRM-EWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDR 185
             +L  A+G  L     R+       +AG I A F  PVA  L   + +  +      + 
Sbjct: 154 GASLGSALGQLLRVPGRRLPILVACGAAGGIAATFNAPVAGVLFALEVILRTFTA---EA 210

Query: 186 LFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLP 245
               ++AA   ++     F     L +  +      +     ++  +A   G++    L 
Sbjct: 211 FGVVVLAAVTASVIGRAAFGDTPFLSLPTFALHSQGEYPLFILLGVVAGLTGVLFTRLLY 270

Query: 246 RLHAMMHQ-MKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLL 304
            +  +     + P  +    G +L    ++  P     G   ++  V    ++     +L
Sbjct: 271 LIEDLCDWAWRGPEWLRPAVGGLLLGTVLLALPQMYGVGYPVLEHTVHGG-YALWFLLVL 329

Query: 305 AVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAV------PAAITVSCAILG 358
              K+ A  +    G  GG   P++F+G + G         +      P        +  
Sbjct: 330 IGGKIVATSLTIGIGGSGGVFAPSLFIGASTGAAFGTLAHHIAPGTIAPVGAYALVGMGA 389

Query: 359 IVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKP 402
           +     R    ++ +   +    T++  L   ++ A L      
Sbjct: 390 VFAGAARAPITAVLILFELTGEYTIILPLMTAVVVATLTSRLLS 433


>UniRef50_A8TQW2 Cl-channel, voltage-gated family protein n=1 Tax=alpha
           proteobacterium BAL199 RepID=A8TQW2_9PROT
          Length = 591

 Score =  224 bits (572), Expect = 4e-57,   Method: Composition-based stats.
 Identities = 62/383 (16%), Positives = 125/383 (32%), Gaps = 18/383 (4%)

Query: 31  MKIASVLQNLLWQRLPGTL--GIAQDSPLWIIGVLTLTGIAVGLVIRFS-----QGHAGP 83
            +  S +Q L        +  G  +     I       G+ VGL+  +            
Sbjct: 43  REAISAVQWLFLGFHHELVASGARESGWWRIALAPAAGGLLVGLITYWLMPGRRPQGVAN 102

Query: 84  DPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARL-LPRV 142
                 L    +      G  V  IL +  G S+G E P + +  ALA  +G  L L R 
Sbjct: 103 VIEASALRAGRMSFRQGIGAAVISILSIGSGASVGREGPAVHLGAALASFVGRPLHLTRS 162

Query: 143 NRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGL 202
                     A  + A F  P+A      + + G   +         ++A+  G + + +
Sbjct: 163 QSRTLLGCGVASAVAASFNAPIAGVFFALEVVIGHYAL---SAFAPIVIASVCGTIVSRM 219

Query: 203 FFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLG 262
           +F    +  +A+Y  +      + A++     AA +  +     +      +  P  +  
Sbjct: 220 WFGDFPAFRLANYEIVSFLQFPAFALLGIACAAAAIALMRLTAMVERTAETLPGPRWLHP 279

Query: 263 IGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRG 322
               ++  +  +  P  L  G +     +  Q +       LAV+K+    +   +GF G
Sbjct: 280 AFAGLIVGVVALWYPEILGVGYEATDNALKEQ-YGFQLLATLAVLKILMTALCLGAGFGG 338

Query: 323 GRIFPAVFVGVALGLMLHEHVPAVPA------AITVSCAILGIVLVVTRDGWLSLFMAAV 376
           G   P++F+G  +G                         +  +   V      ++ +   
Sbjct: 339 GVFSPSLFIGAMVGGSFGLVASHPFPHLSSGHGAYTMIGMGAVAGAVLGAPISTILIIFE 398

Query: 377 VVPNTTLLPLLCIVMLPAWLLLA 399
           +  +  L   + + ++ A LL  
Sbjct: 399 LTSDYRLTIGVMVAVVIASLLTR 421


>UniRef50_C8WVL6 Cl-channel voltage-gated family protein n=1 Tax=Alicyclobacillus
           acidocaldarius subsp. acidocaldarius DSM 446
           RepID=C8WVL6_ALIAD
          Length = 584

 Score =  224 bits (572), Expect = 4e-57,   Method: Composition-based stats.
 Identities = 74/411 (18%), Positives = 143/411 (34%), Gaps = 16/411 (3%)

Query: 2   LHPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIG 61
           L  R    ++L L AVAIG+ +    +   K+  +L  L +      L +       +I 
Sbjct: 30  LTSRLPERVILLLYAVAIGVVAGYGAVGFRKLIDLLDWLFFHVGTSYLRVLGRGD--VIF 87

Query: 62  VLTLTGIAVG-LVIRFSQGHAGP----DPACEPLIGAPVPPSALPGLIVALILGLAGGVS 116
              +  + V  LV RF+    G       A     G  + P  +    VA  L +  G S
Sbjct: 88  FPAIGLVIVSMLVRRFAPEAKGHGVPEVMAAIAERGGVIRPRVVVVKAVASALTIGSGGS 147

Query: 117 LGPEHPIMTVNIALAVAIGARLL-PRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLN 175
           +G E PI+ +  A     G  L  P+          +   I A F  P+   +  ++ + 
Sbjct: 148 VGREGPIVQIGSAFGSVFGQMLGVPKRYLRLMVACGAGAGIAATFNAPIGGVMFAAEVIL 207

Query: 176 GSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIA 235
           GS  +  +    A +M++   A    ++   H S  I  +            ++  ++  
Sbjct: 208 GSFALENFT---AIMMSSVVSAAIGRIYLGNHPSFDIPIHDVGPFRAYWVYVLLGLVSGL 264

Query: 236 AGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQA 295
            G + V  L R+       + P  V  + G I   +  +  P     G   + + ++   
Sbjct: 265 WGTLYVKVLYRVEDWFDARRWPFWVKAVVGGIAVGVIGVWFPQIFGVGYGTIDRALSAHL 324

Query: 296 FSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVP----AAIT 351
                  LL +  L A  +   +G  GG   P ++ G  LG ++   +            
Sbjct: 325 PLYLLGTLLVLK-LLATSITIGAGGSGGVFSPGLYQGAMLGGLVGVMLSHAHIAVSPGAL 383

Query: 352 VSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKP 402
            +  + G+     +    S+ M   +  + +++  L I  + +  +     
Sbjct: 384 AAIGMAGVFAGSAQAPVTSITMLFEMTGDYSMILPLMITSVLSATVAGLIS 434



 Score = 42.5 bits (99), Expect = 0.034,   Method: Composition-based stats.
 Identities = 34/210 (16%), Positives = 68/210 (32%), Gaps = 14/210 (6%)

Query: 217 QMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVL----------VLGIGGF 266
              +  +L    +  +A    +     +  L  +   +    L             IG  
Sbjct: 35  PERVILLLYAVAIGVVAGYGAVGFRKLIDLLDWLFFHVGTSYLRVLGRGDVIFFPAIGLV 94

Query: 267 ILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIF 326
           I+ +L     P +   G+ E+   +A +        ++      A  +   SG   GR  
Sbjct: 95  IVSMLVRRFAPEAKGHGVPEVMAAIAERGGVIRPRVVVVKA--VASALTIGSGGSVGREG 152

Query: 327 PAVFVGVALGLMLHEHV--PAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLL 384
           P V +G A G +  + +  P     + V+C     +          +  AA V+  +  L
Sbjct: 153 PIVQIGSAFGSVFGQMLGVPKRYLRLMVACGAGAGIAATFNAPIGGVMFAAEVILGSFAL 212

Query: 385 PLLCIVMLPAWLLLAGKPMMMVNRPKQQPP 414
                +M+ + +  A   + + N P    P
Sbjct: 213 ENFTAIMMSSVVSAAIGRIYLGNHPSFDIP 242


>UniRef50_C2D6G8 CPA2 family monovalent cation:proton (H+) antiporter-2 n=1
           Tax=Atopobium vaginae DSM 15829 RepID=C2D6G8_9ACTN
          Length = 549

 Score =  224 bits (571), Expect = 5e-57,   Method: Composition-based stats.
 Identities = 58/404 (14%), Positives = 123/404 (30%), Gaps = 15/404 (3%)

Query: 7   RTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLT 66
           R  + L +  V +G+ + L + +        +  +         +     LW++  + L 
Sbjct: 17  RLQIDLVVEGVIVGLLAGLTITLYRITLDKAEEFVMWLHNYMHEMPLVIILWLVIAVCLG 76

Query: 67  GIAVGLVIRFSQGHAGPDPACEPLIGAPVP---PSALPGLIVALILGLAGGVSLGPEHPI 123
            +   L            P  +  I   +       LP   +   +    G+SLG E P 
Sbjct: 77  CVVCFLTRCEPHSKGSGIPHVDAEIKGELSMKWWRVLPFKFLEGSMCSLAGMSLGREGPS 136

Query: 124 MTVNIALAVAIGARLLPRV-NRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPL 182
           + +   +  A+      R   +       +A  + A F  P+   L   + ++   +  L
Sbjct: 137 VQLGAVVGKAVSKLFRRRRIEKRLLITCGAAAGMAAAFHAPLTGTLFALEEIHKEFKPAL 196

Query: 183 WDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVW 242
              L A ++++ A              L       +         ++       G V   
Sbjct: 197 ---LIAAMISSIASDFVVSQILGVQPVLAFHFIKNINHAYYAYILLLGVFCGLLGAVHNA 253

Query: 243 CLPRLHAMM--HQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSD 300
            +  +         K    +  I    +  + +   P     G    + +   Q  +   
Sbjct: 254 GMFFVQETFYAKLEKFHAYLPLIFASCISSIAIYFAPALCCGGDKIFEYLSRAQNLALPA 313

Query: 301 YFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEH------VPAVPAAITVSC 354
              L + K        ASG  GG +FP   +G   G +          +P +     V  
Sbjct: 314 IIALLIGKYFFTTFCFASGAPGGTLFPLCAMGALTGCLFGAFAYTYLGLPQIYIVNFVVL 373

Query: 355 AILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL 398
            + G+   V R    ++ +A  +  +   L  + IV + +++  
Sbjct: 374 GVAGLFASVVRAPVTAVILAFELTGSFNALLAVSIVSIVSYICA 417


>UniRef50_A5TVM5 CIC chloride ion channel family chloride (Cl-):proton (H+)
           antiporter n=9 Tax=Fusobacterium RepID=A5TVM5_FUSNP
          Length = 521

 Score =  223 bits (570), Expect = 8e-57,   Method: Composition-based stats.
 Identities = 60/407 (14%), Positives = 127/407 (31%), Gaps = 19/407 (4%)

Query: 11  LLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAV 70
            L    + +G+ +  I+         +                 S L +  +    G+ V
Sbjct: 17  KLYFACLLVGLITGAIVSAYRWALEEIGIFRSLYFSDINLNNPVSLLKMWLIFIAVGLIV 76

Query: 71  GLVIRFSQGHAGP-DPACEPLIGAPVPPSAL----PGLIVALILGLAGGVSLGPEHPIMT 125
             + +     +G   P  + LI   +  +           A +LG+  G+SLG E P + 
Sbjct: 77  NYLFKKFPKTSGSGIPQVKGLILGRINYNNWFFELLAKFFAGVLGIGAGLSLGREGPSVQ 136

Query: 126 VNIALAVAIGARLLPRV-NRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWD 184
           +   +       L      R       S+  +   FG P+A A+   + ++         
Sbjct: 137 LGSYVGYGASKILKTDTVERNYLLTSGSSAGLAGAFGAPLAGAMFSIEEIHKYLS---GK 193

Query: 185 RLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDIL---SGAIVAAIAIAAGMVAV 241
            L    +A+         FF    S  I     + +          I   I    G +  
Sbjct: 194 LLICAFVASIGADFVGRRFFGVQTSFNIPIKYPLPINPYFQFALYIIFGVIIAFFGKLFT 253

Query: 242 WCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDY 301
             L +   + + +K    +       +  +     P     G   ++ ++  +A      
Sbjct: 254 VTLVKCQDLFNGVKLAREIKVSFIMTISFVLCFILPEVTGGGHSLVESLIHEKAV-IYTL 312

Query: 302 FLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPA------VPAAITVSCA 355
            ++ +IKL    ++ ++GF GG   P + +G  +G +  E V              +   
Sbjct: 313 IIIFIIKLLFTAISYSTGFAGGIFLPMLVLGAIIGKIFGETVDIFAQTGPDFTVHWIVLG 372

Query: 356 ILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKP 402
           +    + V R     + +   +  +  LL  L  V + ++ +     
Sbjct: 373 MAAYFVAVVRAPITGVILILEMTGSFHLLLALTTVAVVSFYVTELLG 419


>UniRef50_A0B965 Cl-channel, voltage-gated family protein n=3 Tax=Euryarchaeota
           RepID=A0B965_METTP
          Length = 580

 Score =  223 bits (570), Expect = 8e-57,   Method: Composition-based stats.
 Identities = 73/438 (16%), Positives = 139/438 (31%), Gaps = 35/438 (7%)

Query: 13  SLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQD-----------SPLWIIG 61
            L A  +G  S L   +   +  +   +    L                      L +  
Sbjct: 5   ILLAAFVGAISGLGAFIFYFLLELSTRVFLTGLDNYTPPKAGDVELVNIDFHIGMLPLPA 64

Query: 62  VLTLTGIAVGL-VIRFSQGHAGPDPACE----PLIGAPVPPSALPGLIVALILGLAGGVS 116
           V+TL G+  GL V +F+    G                +         ++  + +  G S
Sbjct: 65  VVTLGGLLSGLIVYKFAPEAEGHGTDAVIRSFHKARGALRARVPVVKTISSAITIGSGGS 124

Query: 117 LGPEHPIMTVNIALAVAIGARLL-PRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLN 175
            G E PI  +       +   L     +R    +   AG IG++F +P   A+   + L 
Sbjct: 125 AGREGPIAQIGAGFGSFVADLLRLSDRDRRLLVVCGVAGGIGSIFRSPFGGAMFGIEVLY 184

Query: 176 GSSEVPLWDRLFAPLMAAAAGALTTGLF--------FHPHFSLPIAHYGQMEMTDILSGA 227
                   + +    +++    +T  +         F       I         +    A
Sbjct: 185 KKD--YEVEAIVPAFVSSIVAFVTFNVVTSYFAGIPFISPPIFKIPQLSIHSPLEFPLYA 242

Query: 228 IVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEM 287
           +V+ +A   G+  +     +  +    K P  +    G +L     +  P  L  G   +
Sbjct: 243 VVSVLAAFFGVFYIKTFYTIRGLFKSSKIPQTLKPAFGGLLTGSIGMLLPGVLGMGYGYV 302

Query: 288 QQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVP 347
           Q  +  +  + S  FLL + K+AA      SG  GG   P++ +G  +G  +      + 
Sbjct: 303 QMAIDGK-LALSVIFLLILGKIAATSFTVGSGGSGGVFAPSIVIGSMVGAFIGYLFHQLF 361

Query: 348 AAI------TVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGK 401
             I       V   +   +  V +    S+ M   +  +  +LP L I    A+ L    
Sbjct: 362 PEIVVQPEAFVLIGMSAFIAAVAKTPIASILMVLEMCGSYMMLPALMISSALAYCLSGDH 421

Query: 402 PMMMVNRP-KQQPPHDNV 418
            +       + + P   +
Sbjct: 422 SIYSEQVATRAESPAHRM 439



 Score = 46.3 bits (109), Expect = 0.002,   Method: Composition-based stats.
 Identities = 36/234 (15%), Positives = 76/234 (32%), Gaps = 19/234 (8%)

Query: 187 FAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPR 246
           +  L+AA  GA++    F  +F L ++    +   D  +      + +      +  LP 
Sbjct: 3   YTILLAAFVGAISGLGAFIFYFLLELSTRVFLTGLDNYTPPKAGDVELVNIDFHIGMLPL 62

Query: 247 LHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAV 306
                        V+ +GG + G++     P +   G D + +       +      + V
Sbjct: 63  -----------PAVVTLGGLLSGLIVYKFAPEAEGHGTDAVIRSFHKARGALR--ARVPV 109

Query: 307 IKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAA--ITVSCAILGIVLVVT 364
           +K  +  +   SG   GR  P   +G   G  + + +        + V C + G +  + 
Sbjct: 110 VKTISSAITIGSGGSAGREGPIAQIGAGFGSFVADLLRLSDRDRRLLVVCGVAGGIGSIF 169

Query: 365 RDGWLSLFMAAVVV----PNTTLLPLLCIVMLPAWLLLAGKPMMMVNRPKQQPP 414
           R  +        V+         +    +  + A++            P   PP
Sbjct: 170 RSPFGGAMFGIEVLYKKDYEVEAIVPAFVSSIVAFVTFNVVTSYFAGIPFISPP 223


>UniRef50_Q03UF5 Chloride channel protein EriC n=4 Tax=Leuconostoc
           RepID=Q03UF5_LEUMM
          Length = 510

 Score =  223 bits (569), Expect = 9e-57,   Method: Composition-based stats.
 Identities = 66/417 (15%), Positives = 144/417 (34%), Gaps = 18/417 (4%)

Query: 8   TMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTG 67
           + L + L    IG  + +++ V       L   +                 +I    +  
Sbjct: 11  SKLSVVLYGTLIGFLTGIVVSVFRWTIEKLLQFVQTLYLDISHGNIALIFLVITANLICF 70

Query: 68  IAVGLVIRFSQGHAGP-DPACEPLIGAPVP---PSALPGLIVALILGLAGGVSLGPEHPI 123
           + V  ++      +G   P  E L+   +     S L    ++ IL +  G+ LG E P 
Sbjct: 71  LIVSWMLNKEPNISGSGIPQVEGLLLGELKINWWSTLWRKFISGILAIGSGLMLGREGPS 130

Query: 124 MTVNIALAVAIGARLLPRVNR-MEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPL 182
           + +  ++   + +      N+        +A  + + F  P+A  +   + +  S    +
Sbjct: 131 IQLGASIGQGVASYKRLSHNQSKGLIASGAAAGLSSAFNAPLAGVMFVLEEVYHSISPFV 190

Query: 183 WDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVW 242
           W      L  A+     + + F     L I H     +       +   I    G +   
Sbjct: 191 W---VGALTGASVSDFVSTVLFGQTPVLSIGHLSVFPVQLYGLLLVFGIILGLFGFLYQK 247

Query: 243 CLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYF 302
            L        +++ P  + GI  FIL I   I  P  L  G + +  +      +     
Sbjct: 248 FLLFSLNCYSKIRVPKYLYGIVPFILVIPIGILWPNLLGGGNNLILSL-KEAPMTMKMII 306

Query: 303 LLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVP------AAITVSCAI 356
           ++ +++    +++  SG  GG   P + +G   G ++      +       A   +   +
Sbjct: 307 VILLVRFVFSMISYGSGLPGGIFLPILTLGALSGALMAHIFVYLHLMSANYALNFIVIGM 366

Query: 357 LGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL---AGKPMMMVNRPK 410
            G    + +  + ++ +   +V + T +  L +V L A+L++    G P+      +
Sbjct: 367 AGYFACIGKAPFTAIILIFEMVGSVTHILPLALVSLVAYLVVDLLNGAPIYESLLER 423


>UniRef50_D1AXX8 Chloride channel core n=1 Tax=Streptobacillus moniliformis DSM
           12112 RepID=D1AXX8_STRM9
          Length = 538

 Score =  223 bits (569), Expect = 1e-56,   Method: Composition-based stats.
 Identities = 58/436 (13%), Positives = 136/436 (31%), Gaps = 27/436 (6%)

Query: 2   LHPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIG 61
            H R +  L L   ++  G+ + +I+     + S +       +   +       + +  
Sbjct: 16  FHSR-KIRLKLIFYSIITGLITGVIVSSYTLLLSKITIFRNNLIEKNINPLLPLIIILFI 74

Query: 62  VLTLTGIAVGLVIRFSQGHAGPDPACEPLIGAPVPPSALP---GLIVALILGLAGGVSLG 118
            + +  I    + ++        P    LI   V  + LP       + +L +  G SLG
Sbjct: 75  SIAI--IIQYTLNKYPLISGSGIPQVMGLIQKKVKFNWLPELITKFFSGLLAIFIGFSLG 132

Query: 119 PEHPIMTVNIALAVAIGAR-LLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGS 177
            E P + +   +   +        V +       ++  + A F  P++ A+   + L+  
Sbjct: 133 REGPSIHLGSLVGQGVNEISKRTEVEKKYLITCGASAGLAAAFNAPLSGAIFAIEELHKF 192

Query: 178 SEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDI-------LSGAIVA 230
               L   L   L+A+    L +        S     +      ++       +  +I+ 
Sbjct: 193 FSPIL---LICVLIASLFANLISKFLLGTQLSFESFSFISPINFELKEIIIHLILISILC 249

Query: 231 AIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQM 290
            + I    +  + + +   +   ++           +  +L V   P     G   ++ +
Sbjct: 250 FVIILLASIFNYSIIKFKDIYSNIRLSKYTKISIVALFSLLVVYFLPEITGGGHHIIEHL 309

Query: 291 VANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEH------VP 344
           +   + +     L+ V K    +++ ++G  GG   P + +G  +G +            
Sbjct: 310 LEYNS-TFRLLGLILVGKFLFTMISYSTGAPGGIFLPLLVIGALVGKIYGIFLVNTFNFT 368

Query: 345 AVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL---AGK 401
                + V  A+      V R     + +   +  N + L  L I     +         
Sbjct: 369 EEYMTLFVLIAMTSYFTAVVRTPITGIILILEMTGNFSNLFSLVIASTITYAFTELLKHN 428

Query: 402 PMMMVNRPKQQPPHDN 417
            +           HD 
Sbjct: 429 SVYEELFENMFEKHDK 444


>UniRef50_C5BP50 Chloride transporter, ClC family n=1 Tax=Teredinibacter turnerae
           T7901 RepID=C5BP50_TERTT
          Length = 608

 Score =  222 bits (567), Expect = 2e-56,   Method: Composition-based stats.
 Identities = 60/400 (15%), Positives = 128/400 (32%), Gaps = 18/400 (4%)

Query: 11  LLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAV 70
            L++  + +G+ +  +++V   +     +      P            II    +  +A+
Sbjct: 43  QLTILGLIVGLFTGGVIVVFRLLTEQPLSYFMAGQPDNFESFSPRDRVIIIFSGILALAL 102

Query: 71  GLV---IRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVN 127
            L     ++ +   G            +P           ++ L  G S+G E P + + 
Sbjct: 103 VLKLAGKKYRETSVGHVLDRTHNHQGKLPLGNCVVQFAGAVVALVSGQSVGREGPAVHLG 162

Query: 128 IALAVAIGARLL-PRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRL 186
              A  +G  L  P  +         A  I A F TP+A  +   + +     +      
Sbjct: 163 AGAASQLGQWLRLPSNSMHTLVGCGVAAAIAASFDTPMAGVIFAMEVIMMEYTI---VGF 219

Query: 187 FAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPR 246
              ++A+  G   +   F  H  L +       + ++        +      V +     
Sbjct: 220 VPVILASVMGTAVSQAVFGKHSLL-VGSSDMTSLLELPYMVFFGLLIALCAAVYIRLNIF 278

Query: 247 LHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAV 306
                   K PV +          +  I  P  +  G D +   +A +  +     ++A 
Sbjct: 279 ALQF---GKYPVFLRLFAAGFYTAVIAIFVPEIMGLGYDTVNAALAGK-LTVYSLLIIAA 334

Query: 307 IKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPA------AITVSCAILGIV 360
            KLA   V    G  GG I P +F+G  +G ++   +P +        +      + G++
Sbjct: 335 AKLAVTPVVIGLGVPGGVIGPLMFIGACVGGVVGTLLPLLVPEQQTNASFYAVLGMAGMM 394

Query: 361 LVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAG 400
                    +L     +  N  ++    +V++ A +    
Sbjct: 395 AATLNAPLAALVAVLELSYNPHMIFPAMLVIVVACVSTRQ 434


>UniRef50_A7BCR6 Putative uncharacterized protein n=1 Tax=Actinomyces odontolyticus
           ATCC 17982 RepID=A7BCR6_9ACTO
          Length = 595

 Score =  221 bits (565), Expect = 3e-56,   Method: Composition-based stats.
 Identities = 64/412 (15%), Positives = 131/412 (31%), Gaps = 22/412 (5%)

Query: 25  LILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVG-LVIRFSQGHAGP 83
           L +     +++                     L+++    + G+  G L+ RF+    G 
Sbjct: 34  LAIRAWTWVSTGFDEYTTHVGQPHGVWGWTPWLFLLLSPAIAGLLYGPLIQRFAPSAKGH 93

Query: 84  -DPACEPLI---GAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARLL 139
             P     +   G  +P       I+A  L +  G S G E PI+ V  +L   I + L 
Sbjct: 94  GIPEVMLAVRRKGGRIPGRVAIVKILASALTIGSGGSAGREGPIVQVGASLGSTIASWLR 153

Query: 140 PRVNRMEWTI-LASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGAL 198
             V+R+       SA  I A F  P+A A+   + +         +     +++A   ++
Sbjct: 154 MPVSRVVLLASCGSAAGIAATFHAPLAGAVFALEVILVEFTA---ETFGFVVLSAVTSSV 210

Query: 199 TTGLFFHPHFSLPIAHYGQM-EMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMK-- 255
              +       + +A       M+DI   A +  +A   G+     L      +  +   
Sbjct: 211 VARILQGDEMVIRVADNLTFASMSDIWWVAFLGLVAGLCGLGFSKLLYASEDAIDWLWAR 270

Query: 256 --NPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALV 313
              P         +     ++  P     G    +  +A  ++S +    L + +     
Sbjct: 271 THLPEWARPGVLGLALGAALVAFPYMYGSGYPLEEDAIAG-SYSIAFLLALMLGRAVFTS 329

Query: 314 VAAASGFRGGRIFPAVFVGVALGLMLHEHVPAV---PAAITVSCAILGIVLVVTRDGWLS 370
                G  GG   P +F+G   G    + +  +   P  +     +        R    +
Sbjct: 330 FTIGMGGSGGVFAPTLFIGAMAGAAFGDVISPLSDSPVGVFAVVGMGAAFAGAARAPMTA 389

Query: 371 LFMAAVVVPNTTLLPLLCIVMLPAW----LLLAGKPMMMVNRPKQQPPHDNV 418
           + +   +    +L+  + + ++ A      L          R +     D V
Sbjct: 390 VLIIVEMTGQFSLILPMMLAVVIAMGASRFLTRATIYTEKLRRRGDVLDDPV 441


>UniRef50_A6LXJ9 Chloride channel, core n=2 Tax=Clostridiales RepID=A6LXJ9_CLOB8
          Length = 526

 Score =  221 bits (565), Expect = 3e-56,   Method: Composition-based stats.
 Identities = 66/413 (15%), Positives = 144/413 (34%), Gaps = 20/413 (4%)

Query: 10  LLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIA 69
           L L    + IG+ + L++++           L   +   + I     L  I +L + G  
Sbjct: 19  LKLVFEGICIGMVTGLVIVLYRLALEEA-GYLLSYIYKLISINPIIILPWIMLLIVIGYI 77

Query: 70  VGLVIRFSQGHAGP-DPACEPLIGAPVP---PSALPGLIVALILGLAGGVSLGPEHPIMT 125
           VGL+++     +G   P  E ++   +       + G     +L +  G+SLG E P + 
Sbjct: 78  VGLMVKNEPMISGSGIPQVEGVLLRELDMTWWKVILGKFFGGVLSIGSGLSLGREGPSVQ 137

Query: 126 VNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWD 184
           +  A+           ++         ++  + A F  P+A A+   + ++ +    +  
Sbjct: 138 LGAAIGQGFSKVFKRIKIEEKYLITSGASAGLAAAFNAPLAGAMFALEEVHKNFSPLILL 197

Query: 185 RLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCL 244
              +      +       FF          +  + +       I+  I    G++    L
Sbjct: 198 SALSSA---LSADFIASSFFGLKPVFNFGAFATLPLNFYFYVIILGVIVGFLGVLFNKVL 254

Query: 245 PRLHAMM-HQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFL 303
            +   +   Q         I   +L +   +  P +L  G + +  +   + FS     +
Sbjct: 255 LKTQNLYIKQAWLKKEFRIIIPLLLSVALGLLLPEALGGGHELITSLTEGK-FSLILLVI 313

Query: 304 LAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEH------VPAVPAAITVSCAIL 357
           + VIK +  + +  SG  GG   P + +G  +G +  E       +  +     +  A+ 
Sbjct: 314 ILVIKFSFTMASFGSGAPGGIFLPLLTIGALIGNVYGEVLMHIAHLDIIYINNFIILAMA 373

Query: 358 GIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL---AGKPMMMVN 407
           G    V +       +   +  +   L  L IV + ++++    A KP+    
Sbjct: 374 GYFASVVKSPITGTILITEMTGSFNHLLALAIVSVISYIVADLLASKPIYEAL 426


>UniRef50_C9KMS0 Voltage-gated chloride channel family protein n=1 Tax=Mitsuokella
           multacida DSM 20544 RepID=C9KMS0_9FIRM
          Length = 519

 Score =  221 bits (565), Expect = 3e-56,   Method: Composition-based stats.
 Identities = 61/400 (15%), Positives = 126/400 (31%), Gaps = 17/400 (4%)

Query: 10  LLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIA 69
           L L +    IG+A+ +++ +   +  + +  L              P+W + +   + I 
Sbjct: 20  LRLFIEGNIIGVATGMVIALFRYLLELSEEYLPVLYRWLPEHIVWIPIWFLALFLCSWIL 79

Query: 70  VGLVIRFSQGHAGPDPACEPLIGAPVPP---SALPGLIVALILGLAGGVSLGPEHPIMTV 126
             +V +         P  + ++   +       L       +LG+  G+SLG E P + +
Sbjct: 80  YRIVSKDGMTSGSGIPQIKGILLGEMDMNWARVLVLKFTGAVLGIGAGMSLGREGPSVQL 139

Query: 127 NIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDR 185
              L   +G                 +   + A F  P+A  +   + L  +        
Sbjct: 140 GACLGQGLGRLTHRSYAESHYLLTAGAGAGLAAAFNAPLAGVIFCLEELTKNFSA---FV 196

Query: 186 LFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTD-ILSGAIVAAIAIAAGMVAVWCL 244
           L   + AA      T  FF       +     ++  D      ++ A     G+     L
Sbjct: 197 LMGAISAAVTATTVTQYFFGMQPVFHMGVVPVIDTGDMYFLLILLGAFVGLLGLAFNPML 256

Query: 245 PRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLL 304
            R      ++        +       +     P  L  G   +  +V    ++ +   LL
Sbjct: 257 TRSQDFYKKVPARW--RPVVPLFCAGVLGFVLPQVLGGGSRLVDSLVVT-DYTLAFLVLL 313

Query: 305 AVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLH------EHVPAVPAAITVSCAILG 358
              K    +V   SG  GG   P + +G   G +        + +P + A   +   +  
Sbjct: 314 LAAKFLFTMVCFGSGVPGGIFLPMLVLGSVGGAVFAKVAIFFQWMPELFAVNCIVFGMAA 373

Query: 359 IVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL 398
               V +       +   +  +   +  L IV + A+L+ 
Sbjct: 374 YFSAVVKSPITGSILIMEMTGSFEHMLALIIVSMTAYLVA 413


>UniRef50_UPI0001C418FE voltage-gated chloride channel protein n=1 Tax=Methanobrevibacter
           ruminantium M1 RepID=UPI0001C418FE
          Length = 523

 Score =  221 bits (564), Expect = 3e-56,   Method: Composition-based stats.
 Identities = 66/403 (16%), Positives = 143/403 (35%), Gaps = 18/403 (4%)

Query: 7   RTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLT 66
           +  L L + AV IG+ S  I+ +        +++L   L    G      LW   +L + 
Sbjct: 16  KYYLKLIIEAVLIGLFSGFIVSLYRLGLDHSESILSYILKYIQGDLTLIVLW-FVILAIM 74

Query: 67  GIAVGLVIRFSQGHAGP-DPACEPLIGAPVP---PSALPGLIVALILGLAGGVSLGPEHP 122
           G+   L++++     G   P     +           L    +   L   GG+SLG E P
Sbjct: 75  GLITALLMKWDPDSLGSGIPQVMGEVKGYFDVTWWKTLIAKFIGGTLTALGGLSLGREGP 134

Query: 123 IMTVNIALAVAIGARLL-PRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVP 181
            + +    A  +   L   + +     +  S   + A F  P+A  +   + +N   +  
Sbjct: 135 SVQLGAMAAKGVSKYLPNSKTDEKRLLVCGSGAGLAATFSAPLAGFIFTLEEINKGFD-- 192

Query: 182 LWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAV 241
               +   L++A    L + +FF      P      + +       ++       G +  
Sbjct: 193 -RSIVLVGLVSAVVAVLVSNVFFGQSPIFPFTSLN-LPLEYFWLLIVLGIAIGILGYIYN 250

Query: 242 WCLPRLHAMMHQMK-NPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSD 300
             + +   M  ++   P+ +  I  F++  +  +  P  L  G   M  ++       S 
Sbjct: 251 VGMIKAAEMWDKLSFLPLEIKFIIVFLVTGIVGLFLPEVLGGGYSMMH-LIELSLPPLSV 309

Query: 301 YFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAI------TVSC 354
             +L + K   L+    S   GG  +P + +G  +G +    V  +           +  
Sbjct: 310 LIVLLIGKYLLLIFCFGSSAPGGIFYPVLVIGAYIGAIFSAIVIPIFGLNPLIAYKFIMI 369

Query: 355 AILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLL 397
           ++  +     R    ++ + A +   T  +  + +V++ A+++
Sbjct: 370 SMAAMFASSVRTPITAVVLIAEMTGVTNSIVAMIVVVILAYII 412


>UniRef50_B0NZ23 Putative uncharacterized protein n=1 Tax=Clostridium sp. SS2/1
           RepID=B0NZ23_9CLOT
          Length = 518

 Score =  221 bits (563), Expect = 4e-56,   Method: Composition-based stats.
 Identities = 60/400 (15%), Positives = 128/400 (32%), Gaps = 15/400 (3%)

Query: 10  LLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIA 69
           + L    + +GI +  I ++   + +  + LL+  +  T        +W I ++ +  I 
Sbjct: 13  VSLVFDGLLVGIFAGCISVIYRLLLNNAEKLLFTIIAFTKTRPFWIAVWFIVLIVMGLIV 72

Query: 70  VGLVIRFSQGHAGPDPACEPLIGAPVP---PSALPGLIVALILGLAGGVSLGPEHPIMTV 126
             L+           P  +  +   +       L   I+   L + GG+SLG E P + +
Sbjct: 73  GWLMSWEGMASGSGIPQVQGELKGYLNQNWHRVLCSKIIGGTLCILGGLSLGREGPSVQL 132

Query: 127 NIALAVAIGARLL-PRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDR 185
              +A  I       +          +   + A F  P+A  +   + L  +        
Sbjct: 133 GAMVAKGIAKITKKSQTKERYMMTCGAGAGLAAAFNAPLAGVMFSLEELQKNFN---SSM 189

Query: 186 LFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLP 245
           L   +         +   F             + +       ++  +    G    + + 
Sbjct: 190 LVCIISGCVTSDFISKNVFGLSPVFDFHLKAALPLVHYWMLILLGILLGLCGAFYNFIML 249

Query: 246 RLHAMMHQMKN-PVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLL 304
           +   +   MK  P     +  F++  +     P  L  G   +  ++       S   LL
Sbjct: 250 KGQDLFGAMKKIPAKYRIVFPFVVSGIVCYTLPSILAGGHAMI-SLITGHTLLVSTMLLL 308

Query: 305 AVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEH------VPAVPAAITVSCAILG 358
            V K         SG  GG  FP + +G  LG +          +P+      ++ ++ G
Sbjct: 309 LVAKFFFSAFCFGSGAPGGIFFPLLILGAYLGAIYGTLVIQASGIPSYYLVNFITISMAG 368

Query: 359 IVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL 398
               + R     + + A +         L +V + ++L+ 
Sbjct: 369 FFTAIVRAPITGILLIAEMTGTFEHFLSLAVVCIISYLVA 408


>UniRef50_Q0TQI9 Voltage-gated chloride channel family protein n=14 Tax=Clostridia
           RepID=Q0TQI9_CLOP1
          Length = 523

 Score =  220 bits (561), Expect = 8e-56,   Method: Composition-based stats.
 Identities = 74/425 (17%), Positives = 169/425 (39%), Gaps = 20/425 (4%)

Query: 1   MLHPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWII 60
           +L  R      L L   AIG+  SL+L++   I + L   L+++L     ++  + + ++
Sbjct: 9   VLSHRKDLRFKLVLEGAAIGLLCSLVLVLNRIIVNYLFP-LFKKLYAWAALSITNMIIVL 67

Query: 61  GVLTLTGIAVGLVIRFSQGHAGP-DPACEPLIGAPVP---PSALPGLIVALILGLAGGVS 116
            +L + G  VG ++R     +G   P  E  +   +       L    +  ++ L  G+S
Sbjct: 68  VILAILGALVGFMVRREPMISGSGIPQVEGELIGKLKMNWLKILIYKFLGGVISLGAGLS 127

Query: 117 LGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLN 175
           LG E P + +  A+       L    + +       ++  + A F  P++  +   + ++
Sbjct: 128 LGREGPSVQMGAAVGEGFSNGLKRINIEKKYLITSGASAGLAAAFNAPLSGVIFALEEVH 187

Query: 176 GSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIA 235
            S        L + + A+      +  F   + SL I +   + +       I+  I   
Sbjct: 188 KSFSP---LVLVSAMAASLVSDFVSKQFLGMNPSLGIENVPVLPLKYYWVLIILGVILGI 244

Query: 236 AGMVAVWCLPRLHAMMHQMKN-PVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQ 294
            G +    + ++ ++  + KN PV V  +  F+L  +  I  P+ L  G + +  +   +
Sbjct: 245 GGAIFSKGILKVQSLYGKFKNVPVEVKVMIPFLLTGILGIFAPIILGGGHELIMDLA-TK 303

Query: 295 AFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEH------VPAVPA 348
           +F       + ++K    +++  +G  GG  FP + +G  +G ++         VP    
Sbjct: 304 SFPIKLLLAVLLVKFLLTIISFGAGTPGGIFFPLLLLGAVVGNIVGIVSCNAFGVPNQYI 363

Query: 349 AITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWL---LLAGKPMMM 405
              +  A+ G    + +     + +   +  +   +  L +V++ +++   LL  +P+  
Sbjct: 364 IDFIILAMAGNFASIVKAPITGIILITEMTGSFEHMLALSVVVIISYVTSDLLKSEPIYE 423

Query: 406 VNRPK 410
               +
Sbjct: 424 SLLER 428


>UniRef50_A0NVL9 Cl-channel, voltage gated n=2 Tax=Alphaproteobacteria
           RepID=A0NVL9_9RHOB
          Length = 604

 Score =  220 bits (560), Expect = 1e-55,   Method: Composition-based stats.
 Identities = 68/420 (16%), Positives = 139/420 (33%), Gaps = 32/420 (7%)

Query: 4   PRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQ------RLPGTLGIAQDSPL 57
            R  ++ LL L A  IGI +++  +    + S++ NL +                     
Sbjct: 23  ERVFSVPLLCLVAFFIGIVAAIGAVFFRYLISIVHNLFYYGKFSTVYDANQFADPSPLGA 82

Query: 58  WIIGVLTLTGIAVGLVIR-FSQGHAGP----DPACEPLIGAPVPPSALPGLIVALILGLA 112
            +I V  + G+ V  ++R F+    G                V          A  + + 
Sbjct: 83  LVILVPVIGGLIVVFLVRTFAPEAKGHGVPEVMFAIYHKKGDVRGVVALVKSFASAISIG 142

Query: 113 GGVSLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFS 171
            G S+G E PI+ +  +    I   L LPR  ++      +   I A F TP+   L   
Sbjct: 143 TGASVGREGPIIQIGASFGSTIARALHLPRWQKITLLSAGAGAGIAATFNTPLGGVLFAV 202

Query: 172 QTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIA-----HYGQMEMTDILSG 226
           + L               ++A A       + F    +  +          +E   + + 
Sbjct: 203 EMLLPEVS---NRTFLPVVVATATATYAGRIAFGLDPAFIVPISAEEAIEAIEPIQLGAY 259

Query: 227 AIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIG------GPVSL 280
           A++  +A  A    +  L     +  ++        I G ++                + 
Sbjct: 260 ALLGVLAGVASWAFIRTLAWCEDLFPKLPGNDYTQNIIGMLIIGTLSYVLMLTTGHYHTA 319

Query: 281 FKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLH 340
             G   +Q ++ +  ++     +L V K+ A  ++  +G  GG   P++F+G  LG M+ 
Sbjct: 320 GVGYATIQDILNSTPYTLILLAVLFVAKIIATSISLGAGASGGVFSPSLFIGATLGGMVG 379

Query: 341 EHVPAVPAAI------TVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPA 394
                +               +  +V   T     ++ M   +  +  ++  L + +  A
Sbjct: 380 VLCSHLFPDSGFTAVEFALVGMGALVGGATGASMTAIVMIFEMTRDYNVIVPLVLAVAIA 439


>UniRef50_Q12WA6 Voltage-gated ClC-type chloride channel n=5 Tax=Methanosarcinaceae
           RepID=Q12WA6_METBU
          Length = 577

 Score =  220 bits (560), Expect = 1e-55,   Method: Composition-based stats.
 Identities = 67/391 (17%), Positives = 132/391 (33%), Gaps = 21/391 (5%)

Query: 15  PAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVI 74
            A+ IGI + L ++         +++ W            S   +I +  + G+ VG+++
Sbjct: 25  IAILIGIFTGLTIVAYNICLKYAEDIFWS------NSDITSSYIVILIPAIGGLLVGIIV 78

Query: 75  RFSQGHA----GPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIAL 130
            FS                L G  +        +V  I+ +A G S+G E P +     +
Sbjct: 79  FFSGDIHRCNVPEVIEGTALHGGRISVRGAFREVVLSIISIATGGSVGKEAPGILAGSGI 138

Query: 131 AVAIGARLLPRVNR-MEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAP 189
                  L    +R        +AG I A F  P+A  +   + + G  E          
Sbjct: 139 GSIFAKALKAPDHRYRTLIGCGAAGGIAAAFNAPLAGVVFVVEVILGELET---RTFIPI 195

Query: 190 LMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHA 249
           +++A    L   L F         +     + + +   I+  +     ++ +  L  +H 
Sbjct: 196 VISAVFATLVANLIFEVKPIQISYYGLVDPIGESILYLILGTLCGITSVLLIRTLFTVHD 255

Query: 250 MMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKL 309
              ++          G +L  L     P     G D +  ++ N +F+     +L V+K+
Sbjct: 256 GFSKLPIHSAFKPAIGGLLVGLMGYFYPQIRGIGYDVIADVLTN-SFTIQLLLVLFVLKI 314

Query: 310 AALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPA------AITVSCAILGIVLVV 363
            A      SG  GG I P++F G  LG      V ++               +   +   
Sbjct: 315 LAFSFTIGSGGAGGSIVPSMFAGAMLGGAYGTLVHSIFPTSTAAAGAYALVGMGATLAGT 374

Query: 364 TRDGWLSLFMAAVVVPNTTLLPLLCIVMLPA 394
            R    ++ +   +  N  ++  L    + +
Sbjct: 375 ARAPLTAVLILFELTQNYNIILPLMFACVVS 405


>UniRef50_A5UNZ8 Voltage gated chloride channel protein/cation transporter, TrkA
           family n=2 Tax=Methanobrevibacter smithii
           RepID=A5UNZ8_METS3
          Length = 522

 Score =  219 bits (559), Expect = 1e-55,   Method: Composition-based stats.
 Identities = 75/422 (17%), Positives = 148/422 (35%), Gaps = 18/422 (4%)

Query: 7   RTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLT 66
           + +  L++  + +GI + +++ +   +    +++L   L    G       W I +  L 
Sbjct: 16  KHIFKLAVQGIFVGIFAGIMVCLYRFLLYSSESILRNFLEFINGNIFLIIAWFIILAILG 75

Query: 67  GIAVGLVIRFSQGHAGPDPACEPLIGAPVP---PSALPGLIVALILGLAGGVSLGPEHPI 123
                LV           P     +   +       L   I A +L   GG+SLGPE P 
Sbjct: 76  LFTAFLVKWEPDSIGSGIPQINAEVKGFLNTNWLKILTAKISAGVLTALGGLSLGPEGPS 135

Query: 124 MTVNIALAVAIGARLL-PRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPL 182
           + +       I       R + +   +  S   I A F  P+A  +   + +N S +  L
Sbjct: 136 VQIGGMAGKGISRIFKESRTDELRLILAGSTVGITAAFNAPLAGVIFIIEEINHSFDKTL 195

Query: 183 WDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVW 242
              +F  L A+      +  FF     L    +     +  L   +   + I   +  V 
Sbjct: 196 ---IFIALTASVVADFISKSFFGQATVLNFPLHNLPLSSYWLLIVLGLLLGILGYVYNVG 252

Query: 243 CLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYF 302
            +     +      P+ +  I  F++  +  +  P  L  G   +  M+           
Sbjct: 253 MIRANDRLAKMSNIPLEIKFICVFLISGVVALFIPEILDGGHFML-DMLDVAIPPLGILI 311

Query: 303 LLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAI------TVSCAI 356
            L V K    VV+ ++G  GG   P + +G  +G +    V  +           +  ++
Sbjct: 312 FLLVAKYLFSVVSFSAGTPGGIFLPLLVLGAFIGAIFGSVVIPIFGLESYLIYKFIVISM 371

Query: 357 LGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNRPKQQPPHD 416
            G      R     + + + +  +T  L  + IV + A+ +    PM++ NRP  +   +
Sbjct: 372 AGFFAATVRSPITGVVLLSEMCGSTESLVAMLIVAIIAYAV----PMLLNNRPIYESLFE 427

Query: 417 NV 418
            +
Sbjct: 428 RL 429


>UniRef50_A2BJY0 Voltage-gated chloride channel protein n=1 Tax=Hyperthermus
           butylicus DSM 5456 RepID=A2BJY0_HYPBU
          Length = 563

 Score =  219 bits (558), Expect = 2e-55,   Method: Composition-based stats.
 Identities = 68/425 (16%), Positives = 145/425 (34%), Gaps = 14/425 (3%)

Query: 1   MLHPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLL--WQRLPGTLGIAQDSPLW 58
           M   R  ++    +    +G+ S L   ++     V+  L   +  +    G   +  L 
Sbjct: 1   MRRLRIPSLEKWVMLGTLVGVVSGLAGTLLTVGIEVIAELFAEYSGIDLIKGEVSEPSLV 60

Query: 59  IIGVLTLTGIAVGLV-IRFSQGHAGP----DPACEPLIGAPVPPSALPGLIVALILGLAG 113
           +  ++ L G+A GL+   F+    G             GA + P      + A    +  
Sbjct: 61  LPLLVALGGLASGLLTYMFAPEAEGHGTDSVLEAFHWRGAFIRPRVPLVKLAASSALIGL 120

Query: 114 GVSLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQ 172
           G S G E PI  +       +   L L R  R    +   AG I A+F  P+ A L   +
Sbjct: 121 GGSAGKEGPIALIGAGFGSVLADILHLTRNERRLLVLAGVAGGISAVFRAPLGAMLFALE 180

Query: 173 TLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAI 232
                      + +    +A+    + +         L +   G     +++  A++  +
Sbjct: 181 VPYKRDME--VEAILPLGVASIVAYVASVTILGSGRLLWLPEVGLQSSLELVLYAVLGIV 238

Query: 233 AIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVA 292
           A     V V     +      +  PV++    G ++     +  P +L +G   +++ + 
Sbjct: 239 AGLVAKVYVRLFYEIRDAFKVLPIPVMLKPALGGLVAGFIGLLLPHTLGQGYPFLERALL 298

Query: 293 NQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAI-- 350
            +  +        + K+     + ASG  GG   P++F+G  LG    +     PA I  
Sbjct: 299 GK-LALPVIVAAIIGKMLTNAFSIASGGSGGVFAPSLFIGGMLGAAFAQLYTDNPATIAS 357

Query: 351 TVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNR-P 409
                +        +  + S+ + + +     L+    + +  ++++     +       
Sbjct: 358 FSVVGMAAFFAAAGKVPFTSIIIVSEITRGYELIVPSVVAVTLSYVVSGQDSIYEKQVNT 417

Query: 410 KQQPP 414
           +   P
Sbjct: 418 RADSP 422


>UniRef50_B1ZT36 Chloride channel core n=1 Tax=Opitutus terrae PB90-1
           RepID=B1ZT36_OPITP
          Length = 591

 Score =  218 bits (555), Expect = 4e-55,   Method: Composition-based stats.
 Identities = 61/413 (14%), Positives = 133/413 (32%), Gaps = 19/413 (4%)

Query: 2   LHPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIG 61
           L P    + L    A   G   +L  ++   +   +  LL  R  G +   +  P W   
Sbjct: 29  LQPTEWQITLWW--AALAGFVGALSSLLFSVLTEGIHELLTGRSDGVVETMRQLPWWACV 86

Query: 62  VLTLTGIAVGLVIRFSQG------HAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGV 115
            +  TG  +                +        +    +P  +      A +  +  G 
Sbjct: 87  AVPATGGLLAGATLLLGKRLSQGQSSTDYMEAIAIGSGRIPVRSSLLKSAAALFSIGSGG 146

Query: 116 SLGPEHPIMTVNIALAVAIGARLL-PRVNRMEWTILASAGTIGALFGTPVAAALIFSQTL 174
           S+G E P++ +    A  +G                 +A  I + +  P+A +   ++ +
Sbjct: 147 SIGREGPMVQLAALQASMLGRWRRFSPPQLRLLVACGAASGIASAYNAPIAGSFFVAEII 206

Query: 175 NGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAI 234
            G+  +   + L    ++A A ALT  +         +  +      ++L   ++  I  
Sbjct: 207 LGTIAM---ESLGPLAVSAVAAALTVRVLTDAQHLYQVPAFRLDSPWEMLPYVMLGFIEG 263

Query: 235 AAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQ 294
                 +  L R   +      P +   + G +L     I  P     G   + +++  Q
Sbjct: 264 TLAPWFLRSLRRAEKLFVVTTIPPIARLVLGGMLVGGIAIFFPQVAGNGYTVVLEILNGQ 323

Query: 295 AFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAIT--- 351
                    + + K  A   +  SG  GG   P++F+G + G +    V +   A     
Sbjct: 324 VV-WLALVGIMIAKWLATASSFGSGAPGGVFTPSLFMGASAGYLFGTAVHSFWPAGAPDP 382

Query: 352 ---VSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGK 401
                  +   +   +    +++ M   +  +  ++  L +  + A+    G 
Sbjct: 383 QACALVGMGAFLSAASYAPVMAIIMLFEMTLSYDIILPLMLCNVIAYYTAKGL 435


>UniRef50_B0CCE6 Cl-channel, voltage gated n=3 Tax=Cyanobacteria RepID=B0CCE6_ACAM1
          Length = 465

 Score =  217 bits (554), Expect = 5e-55,   Method: Composition-based stats.
 Identities = 88/418 (21%), Positives = 174/418 (41%), Gaps = 13/418 (3%)

Query: 4   PRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPL----WI 59
            R  T   L + A  IG+   L+      +   L + +W  +P  +     S L    ++
Sbjct: 23  KRELTYSQLVICAALIGVFGGLVATAYYFVLETLMHGVWHTVPDRVVPYFPSWLPQQHYV 82

Query: 60  IGVLTLTGIAVGLVIRFSQGHAGPDPACEPLIG--APVPPSALPGLIVALILGLAGGVSL 117
               T+ G  VGLV+ F  G  G        I     +     P +I+A ++ +  G S 
Sbjct: 83  WIASTIGGFCVGLVL-FFMGLPGEMAQVVDKIHSPGKIDIRKTPAMIIASLVAITSGGSA 141

Query: 118 GPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNG 176
           GPE P++ VN +    +G +L L   +    T    +  +GA FG P+ AAL   + +  
Sbjct: 142 GPEAPLVQVNGSFGSWLGEKLQLTTTSVRVLTFCGMSAALGAFFGAPIGAALFALE-IPH 200

Query: 177 SSEVPLWDRLFAPLMAAAAGALTTGLFFH--PHFSLPIAHYGQMEMTDILSGAIVAAIAI 234
              +  ++ +   +++A        +                 +  T++L G ++  I  
Sbjct: 201 RKGLEYYEAIAPAVVSAIFSFAVFRINTGMTIGGFYHFETVPPLTPTNLLEGLVLGGIGA 260

Query: 235 AAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMV-AN 293
              ++ +     +  ++  +++  ++L   G +   L  +  P +LF   +++  ++   
Sbjct: 261 GVAVMFIGVFRLVGHLLAPLEHHRILLATLGGLTIGLIALAFPQTLFFSEEQIHTVIETG 320

Query: 294 QAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVS 353
                +   ++AV K+ A+ V   SGF GG IFP  F+G  +GL +   VP V   + + 
Sbjct: 321 ATLGITFLLMIAVAKMFAISVTLHSGFLGGFIFPLFFIGANVGLAISLMVPQVHPTLGMV 380

Query: 354 CAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNRPKQ 411
           C +  + + VT+    S  +   V+    +LP++ I    ++LL +   M+   R ++
Sbjct: 381 CLMAAVNVAVTKTPV-STSIILSVLSGMAMLPVIVISSFVSFLLTSQIAMIKTQRSRE 437


>UniRef50_Q6SGK9 Voltage-gated chloride channel n=4 Tax=Bacteria RepID=Q6SGK9_9BACT
          Length = 592

 Score =  217 bits (553), Expect = 7e-55,   Method: Composition-based stats.
 Identities = 62/401 (15%), Positives = 137/401 (34%), Gaps = 20/401 (4%)

Query: 8   TMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTG 67
           ++L  SL  V  G+AS L+++   +  + L   LW             PL+   +  +  
Sbjct: 35  SVLAYSLLGVIGGVASGLVILGFEESIAYLAA-LWGVGNSGEDFESLPPLFRFLLPAIGA 93

Query: 68  IAVGLVIRFSQG-----HAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHP 122
           + +G+  +  +            +        +P              LA G S G E P
Sbjct: 94  LLLGICYQMLRNEDREVGIVHVLSRMHSHYGALPARNAIIQFFGGAFALASGQSGGREGP 153

Query: 123 IMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVP 181
            + +  A+   +G RL LP  +        +AG I A F TP+A  +   + +     V 
Sbjct: 154 GVHLGGAINSLLGQRLGLPNNSLRVLIACGTAGGIAAAFNTPLAGVIFAMEVIIAEYTV- 212

Query: 182 LWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAV 241
                   ++AA + +  +  F        I       + +I    ++      A +  V
Sbjct: 213 --VGFIPVMLAAVSASAVSRTFATGGAVFNIPSLQLTSLWEIPYIVLLGFSCGLAVVAFV 270

Query: 242 WCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDY 301
                   + H   + V+       ++     +  P  +  G D ++  +  +  +    
Sbjct: 271 QISKHTARLSH---HAVIFRFTAAGVITGALALFVPEIMGIGYDTLRLALNGE-VALLAL 326

Query: 302 FLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLH----EHVPAV--PAAITVSCA 355
            ++A  K+ A  +   +G   G I P + +G  LG  +     + +P +     + +   
Sbjct: 327 VVIAGAKIIATSITVGAGMPVGIIGPNLLIGACLGGAMGMIGNQFMPGLASDPTLYILIG 386

Query: 356 ILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWL 396
           +   +  +      ++     +  + ++     + ++ A L
Sbjct: 387 MGSAMGAIMNAPLAAILAVLELTHSMSIAMPAMLAIVAATL 427


>UniRef50_Q14FN1 Voltage-gated ClC-type chloride channel clcA n=9 Tax=Francisella
           RepID=Q14FN1_FRAT1
          Length = 509

 Score =  217 bits (553), Expect = 7e-55,   Method: Composition-based stats.
 Identities = 60/423 (14%), Positives = 136/423 (32%), Gaps = 18/423 (4%)

Query: 3   HPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGV 62
           +   R + +L L    IG    L+      +   +  +       + G         I +
Sbjct: 18  YKNNRHIWVLVLSGAVIGTMIGLLATAFQLLLDFIFKIKLALFSFSGGNLFIEIAMSISL 77

Query: 63  LTLTGIAVGLVIRFSQGHAGP--DPACEPLIGA--PVPPSALPGLIVALILGLAGGVSLG 118
             +  +    +++     AG       E  +     +    +P   ++ +  L  G+SLG
Sbjct: 78  SIVMVLISIFIVKKFAKEAGGSGIQEVEGALKGCRKIRKRVMPVKFISGLFSLGSGLSLG 137

Query: 119 PEHPIMTVNIALAVAIGARLLPRVN-RMEWTILASAGTIGALFGTPVAAALIFSQTLNGS 177
            E P + +  ALA     +               +   + A F TP++  +   + +N  
Sbjct: 138 KEGPSIHMAAALAQFFVDKFKLTTKYANAVISAGAGAGLAAAFNTPLSGIIFVIEEMNRK 197

Query: 178 SEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAG 237
               +   +   L+A     + +        ++ +  +  +    +    ++  I    G
Sbjct: 198 FRFSVS-AIKCVLVACIMSTVISRAIMGNPPAISVETFSSVPQNTLWLFMVLGIIFGYFG 256

Query: 238 MVAVWCLPRLHAMMHQ-MKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAF 296
           ++    L ++     +  K     L I   I+  +GV+  P ++  G   +   + +   
Sbjct: 257 LLFNKSLIKVTNFFSEGSKKRYWTLVIIVCIIFGIGVVLSPNAVGGGYIVIANTL-DYNL 315

Query: 297 STSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVP------AAI 350
           S     +L V++ A ++ +  +G  GG   P + +G   GL     V  +         +
Sbjct: 316 SIKMLLVLFVLRFAGVIFSYGTGVTGGIFAPMIALGTVFGLDYGLSVAQLFPQYNIEPGV 375

Query: 351 TVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNRPK 410
                +  +           + +   +  N  LL  L I    A +L      +   +P 
Sbjct: 376 FAVAGMSALFTATVGAPLTGIVLVMEMTWNFHLLLPLMITCFSASMLT----YIHHQKPI 431

Query: 411 QQP 413
              
Sbjct: 432 YDT 434


>UniRef50_Q73KN8 Voltage-gated chloride channel n=2 Tax=Treponema RepID=Q73KN8_TREDE
          Length = 528

 Score =  216 bits (552), Expect = 8e-55,   Method: Composition-based stats.
 Identities = 68/405 (16%), Positives = 138/405 (34%), Gaps = 18/405 (4%)

Query: 8   TMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQ----RLPGTLGIAQDSPLWIIGVL 63
             L+++  +  +GI + L +    K    L +L        + G  G      + I+ V 
Sbjct: 18  NHLIITGESFIVGILTGLAITAFRKSIDFLSSLRIDVYDKAVSGQFGTVFGFGVLILAVT 77

Query: 64  TLTGIAVGLVIRFSQGHAGPDPACEPLIGAPV---PPSALPGLIVALILGLAGGVSLGPE 120
            L      ++ ++           +      +   P   LP   +  +L ++ G+S+G E
Sbjct: 78  VLGLFMGFIIKKYPMIKGSGVSQIKGKFMKKLDMSPWPELPLKFLGGVLNISAGLSVGRE 137

Query: 121 HPIMTVNIALAVAIGARLLPRVNRME-WTILASAGTIGALFGTPVAAALIFSQTLNGSSE 179
            P + +   +  A                   +A  + A FG P A  +   + L+    
Sbjct: 138 GPSVQIGAYIGSAFEKIGKTSHIERVCLVTSGAAAGLAATFGAPFAGIVFAIEDLHQYLS 197

Query: 180 VPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMV 239
             L   L   ++ A AG L T LFF               +       ++ A A   G +
Sbjct: 198 PLL---LTCVMLGAFAGDLATSLFFKQGAIFDFHGLQLFPIKYFGWLILMGAAAALIGHL 254

Query: 240 AVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTS 299
               +     M  ++K P     +  +++ +   I  P++   G   ++ +  + +F  S
Sbjct: 255 FKKSIYTSQKMYRKLKIPPQFSPLIPYLISVPVCIFLPLAASGGDHLIEAIAEH-SFPLS 313

Query: 300 DYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHV------PAVPAAITVS 353
              L+   K+    ++A SG  GG   P +  G   G++    +       A  A   + 
Sbjct: 314 MLVLILAAKIIFTGLSAGSGAIGGIFVPLLSCGALTGIIFSNILVYFNLIEAQYAVNLMV 373

Query: 354 CAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL 398
            A+      V +    ++ + A    +   L  L +    A++  
Sbjct: 374 FAMAAFFTTVIKAPITAIVLLAETSGDLFHLGGLVLTTAAAYITA 418


>UniRef50_C0QAG4 EriC1 n=1 Tax=Desulfobacterium autotrophicum HRM2
           RepID=C0QAG4_DESAH
          Length = 576

 Score =  216 bits (552), Expect = 1e-54,   Method: Composition-based stats.
 Identities = 67/410 (16%), Positives = 134/410 (32%), Gaps = 27/410 (6%)

Query: 5   RARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLT 64
           R    LLL    V +G++S L  I + +    +   L                W   +  
Sbjct: 17  RMDDRLLLISIGVIVGLSSGLAAIGLNRSLVFMLEGLHHL---------RHQWWAFLLPA 67

Query: 65  LTGIAVGLVIRFSQGHA-----GPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGP 119
              +A  L +                      G  +   +    +++  L +  G S GP
Sbjct: 68  AGAMASALFLDKIMKEGAGHGVPEVIYSVSRYGGLLRFRSSFSRLISSCLTIGSGGSAGP 127

Query: 120 EHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSS 178
           E P++    A+   I     L    R       +AG I  +F  P+   +   + + G  
Sbjct: 128 EAPVVMSGAAIGSTIARFFNLNDRQRTTLVGCGAAGAIAGIFNAPLTGIIFTMEIILGEW 187

Query: 179 EVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGM 238
            +     +    +A+ AGA  + L      +   + +  +   D+ +   +A +A  A +
Sbjct: 188 SM---VNIIPIAVASVAGAEVSRLLQGNSIAFESSGF-HITGVDLFASLGLAVVAAFASI 243

Query: 239 VAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQ-AFS 297
           +    L R+H +  +++ P+ V    G     L     P  L +G   +  M+       
Sbjct: 244 LLTRSLRRMHGVSAKVRVPLWVRAAIGGCAVGLLGYVVPEVLGEGYHSIHAMIQGVFKGG 303

Query: 298 TSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAI------- 350
                L    K+ A  +    G  GG   P + +G   GL  H  +     +        
Sbjct: 304 IGIAALAFFAKILATSLTLGWGGSGGVFAPCLVIGSFAGLAFHRLLVFGFPSAMLVNEGC 363

Query: 351 TVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAG 400
                + G++  + +     +F+   +  +  ++  L IV   +  +   
Sbjct: 364 FALLGMAGLISGILQAPLTGIFLILEITGSYEVMLPLIIVSAISTTITHY 413


>UniRef50_Q1K0X2 Cl-channel, voltage gated n=1 Tax=Desulfuromonas acetoxidans DSM
           684 RepID=Q1K0X2_DESAC
          Length = 587

 Score =  216 bits (552), Expect = 1e-54,   Method: Composition-based stats.
 Identities = 62/434 (14%), Positives = 149/434 (34%), Gaps = 28/434 (6%)

Query: 1   MLHPRAR------TMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQD 54
           +  PR R       ++ L L A  IG+ +  + +    +      L W      +     
Sbjct: 8   VFSPRERMRGHGWRIVFLLLIAATIGVVTGTLAVAFRYLLLETTALFWGESYDLVAATAA 67

Query: 55  SPLWIIGVLTLTGIAVG--LVIRFSQGHAG----PDPACEPLIGAPVPPSALPGLIVALI 108
            P +++  + + G  +   ++ RF+    G                +        +    
Sbjct: 68  MPWYLVVAIPVAGGLILGPILERFAPEARGAGVPEVIESVVTREGNIRHRTTLFKMFCTT 127

Query: 109 LGLAGGVSLGPEHPIMTVNIALAVAIGARLLPRVN-RMEWTILASAGTIGALFGTPVAAA 167
           L L  G S+G E P++ +  ++  ++   +      +  +    +A  I A F  P+A  
Sbjct: 128 LSLGCGASVGREGPVVHIGSSVGSSLAQLMKLSPEWKRVFLACGAAAGIAATFNAPMAGM 187

Query: 168 LIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGA 227
           L  ++ +    ++    ++    ++A    + +  F     +  +  +  +   +I    
Sbjct: 188 LFAAEIILVDFQINYLSQI---AVSAVTATVVSHRFLGSFPTFDVPAFQLLSYWEIPLYL 244

Query: 228 IVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEM 287
           I+  +A    +V +  + R+    + MK P+      G +L     +  P  L  G   +
Sbjct: 245 ILGVLAGFLAIVFIQLINRVEDSCNLMKLPLWSRPALGGVLVGGLALLSPYVLGVGYQAI 304

Query: 288 QQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPA-------VFVGVALGLMLH 340
            +++       +    + + KLAA  ++   GF GG   P+         +   L     
Sbjct: 305 NEVL-TADLVPAVMVAILLAKLAATAISVGVGFSGGIFAPSLVLGGLLGGLFGCLAQAFA 363

Query: 341 EHVPAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL-- 398
            H+ A    +     +  +V   T     ++F    +  N  ++  L    + + +++  
Sbjct: 364 PHLVAEFP-VYALVGMAAMVSGTTLAPITAIFTIFELTYNFEIILPLMTSCIASLVIVQS 422

Query: 399 -AGKPMMMVNRPKQ 411
             G  +      ++
Sbjct: 423 FYGLSIYETRLVRR 436


>UniRef50_Q1N3I5 Chloride channel, putative n=1 Tax=Bermanella marisrubri
           RepID=Q1N3I5_9GAMM
          Length = 590

 Score =  216 bits (550), Expect = 1e-54,   Method: Composition-based stats.
 Identities = 62/407 (15%), Positives = 130/407 (31%), Gaps = 17/407 (4%)

Query: 7   RTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLT 66
           +  L + L    +G+ S++   + +     L  +L   +         S  WI+ V  + 
Sbjct: 29  KNALFVVLFGSVVGVVSAIFADLFVYGFKYLNQIL--NISAASQHESISFWWILLVPCIG 86

Query: 67  GIAVGLVIRFS----QGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHP 122
           G+ VGL  R+             A   L  + VP  +     +A  + L  G S+G   P
Sbjct: 87  GLVVGLFNRYINPDKPQGPPDVIAAAQLGHSQVPFKSGMSTALASFMSLGSGASVGGYGP 146

Query: 123 IMTVNIALAVAIGARLLPRVNRMEWTILASAGTIGALFGT--PVAAALIFSQTLNGSSEV 180
           I+ +   L VA           +    +              P+A      + +     +
Sbjct: 147 IVHLGATLGVAFRKFAYGGGGHIANIGIGCGVAGAIAAAFNAPLAGMFFAHEVVLRHYSL 206

Query: 181 PLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVA 240
                     ++A  G + T +         I   G +   +  S  ++        +V 
Sbjct: 207 ---RAFAPITVSATMGYIVTAVILERPPLFQIDQIGHLNAWEYSSFMLIGVTGAMLAVVF 263

Query: 241 VWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSD 300
           +  L +   +   +  P  +          L  +  P  L  G   +Q  +  ++     
Sbjct: 264 MRTLLKSQKIAQGLNMPNTLKPALAGFALGLVALQLPELLGLGTALLQSAMIPESIEAPQ 323

Query: 301 YFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPA------AITVSC 354
             +L V KL    +    GF GG   P++ +GV  G ++   +  +         +   C
Sbjct: 324 MAMLLVGKLVVTAMCLGFGFVGGVFSPSLVIGVLFGSLVGLVLAPIMPGAADSLGVFAIC 383

Query: 355 AILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGK 401
            +  +   V      ++ +   +  N  L   + + ++ + L+    
Sbjct: 384 GMAAVTTAVIGAPISTILIILELTRNYELTTAVLLSVVFSNLVSYRL 430


>UniRef50_Q8DIV5 Tlr1476 protein n=1 Tax=Thermosynechococcus elongatus BP-1
           RepID=Q8DIV5_THEEB
          Length = 420

 Score =  216 bits (550), Expect = 1e-54,   Method: Composition-based stats.
 Identities = 104/412 (25%), Positives = 178/412 (43%), Gaps = 9/412 (2%)

Query: 11  LLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLW--IIGVLTLTGI 68
            L L A+ IG+ S  +         +   LLW   P  + IA    L+  I  V    G+
Sbjct: 10  RLLLYALIIGLLSGCVTTAFYLGLKLGFALLWGTDPSQVSIATWEHLYPYIPLVTAFGGL 69

Query: 69  AVGL-VIRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVN 127
            VGL V  F       D   E   G  +    LPG+ +A  L L  G S GPE P++ +N
Sbjct: 70  LVGLSVKFFGAKGELADAIAELHHGGRLSYRFLPGMALASGLSLLFGSSAGPESPMIDIN 129

Query: 128 IALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRL 186
             L   + ARL L   +    T+   A  +   F +P+ A L   + +     V  ++ +
Sbjct: 130 GGLGTWLAARLNLSPASTRILTLCGMAAGMSVFFESPLGATLFVLE-IPHRRSVEFYEAI 188

Query: 187 FAPLMAAAAGALTTGLFFHPHFS--LPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCL 244
              L++AAAG     +              Y  +   DI    ++  I  A G + V+  
Sbjct: 189 IPALISAAAGFTLFRVITGTTIGAIYRFPTYDSLRPQDIGFAVLLGFIGAAVGTLFVFLD 248

Query: 245 PRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVA-NQAFSTSDYFL 303
            ++   +   +   L+L +    L  +  +  P++LF G  +++Q++     +S      
Sbjct: 249 RQIQRWLTPYRQYPLLLIVVVGFLIGVIALIHPITLFYGERQIEQVIEVVNRYSIGILLR 308

Query: 304 LAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLVV 363
           +A  KL AL +    GFRGG +FP  FVG  +G+ +H+ +P  P ++ ++  +  + +VV
Sbjct: 309 VAFFKLLALSLCLRGGFRGGVVFPLFFVGACVGMAVHQALPNTPLSVALAGMMAAVTVVV 368

Query: 364 TRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNRPKQQPPH 415
           T+     L +   V+ +T +LPL+ I  L ++LL      +   R ++  P 
Sbjct: 369 TKTPL-GLAIILTVISHTAMLPLMTIATLTSYLLTLPIGWIPSQRSREDTPD 419


>UniRef50_D0LKI3 Cl-channel voltage-gated family protein n=1 Tax=Haliangium
           ochraceum DSM 14365 RepID=D0LKI3_HALO1
          Length = 651

 Score =  215 bits (549), Expect = 2e-54,   Method: Composition-based stats.
 Identities = 71/375 (18%), Positives = 129/375 (34%), Gaps = 25/375 (6%)

Query: 56  PLWIIGVLTLTGIAVGLV-IRFSQGHAG----PDPACEPLIGAPVPPSALPGLIVALILG 110
              II    L G+A GLV  RF+    G             G  +        ++  +  
Sbjct: 98  WALIILTPALGGLAAGLVSWRFAPETEGAGVDNVLDAYHNRGGRMRKRTPTVKLITTLFT 157

Query: 111 LAGGVSLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALI 169
           L  G S G E P+  +   +   +  R  L +  R    +  +AG + ALF  P+ AAL 
Sbjct: 158 LGSGGSAGREGPMAQIGAGVGAYVADRFGLSKRERRLLLLAGAAGGVSALFRAPLGAALW 217

Query: 170 FSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIV 229
             + L         + LF  L+++          + P     ++     + T +L   ++
Sbjct: 218 SLEVLYRKDFE--SEGLFPCLVSSVTAYSVFTTIYEPGSLFFVSVRYHFQPTQLLFYGLM 275

Query: 230 AAIAIAAGMVAVWCLPRLH-AMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQ 288
           A +    G++ +  L +    +   M+ PV +    G +   +  +  P     G   MQ
Sbjct: 276 ALVCAPFGLLWITLLRQARTRLWEPMRVPVWLKPALGGLALGIFCVFVPWVFSTGYGWMQ 335

Query: 289 QMVAN----------QAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGL- 337
             +                 +    LAV K+ A  +  +SG  GG   P +F+G  +G  
Sbjct: 336 DALRPIGDTSRNLPVGYQGFAMLLGLAVAKMIATSLTVSSGGSGGVFAPTLFIGGFIGGA 395

Query: 338 ---MLHEHVPAV--PAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVML 392
              + H   P +    +  V   +      V R    ++ + + +  +  LL  L    +
Sbjct: 396 FGQLFHVLAPGIVSQPSAFVLVGMGAFYAGVARTPIATIILISEMFGSYDLLVPLMFCEM 455

Query: 393 PAWLLLAGKPMMMVN 407
               LL    +    
Sbjct: 456 ITMRLLGRHTLYGQQ 470


>UniRef50_Q0BP43 CLC family chloride ion channel antiporter n=25 Tax=Francisella
           RepID=Q0BP43_FRATO
          Length = 472

 Score =  215 bits (547), Expect = 3e-54,   Method: Composition-based stats.
 Identities = 60/423 (14%), Positives = 136/423 (32%), Gaps = 18/423 (4%)

Query: 3   HPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGV 62
           +   R + +L L    IG    L+      +   +  +       + G         I +
Sbjct: 18  YKNNRHIWVLVLSGAVIGTMIGLLATAFQLLLDFIFKIKLALFSFSGGNLFIEIAMSISL 77

Query: 63  LTLTGIAVGLVIRFSQGHAGP--DPACEPLIGA--PVPPSALPGLIVALILGLAGGVSLG 118
             +  +    +++     AG       E  +     +    +P   ++ +  L  G+SLG
Sbjct: 78  SIVMVLISIFIVKKFAKEAGGSGIQEVEGALKGCRKIRKRVMPVKFISGLFSLGSGLSLG 137

Query: 119 PEHPIMTVNIALAVAIGARLLPRVN-RMEWTILASAGTIGALFGTPVAAALIFSQTLNGS 177
            E P + +  ALA     +               +   + A F TP++  +   + +N  
Sbjct: 138 KEGPSIHMAAALAQFFVDKFKLTTKYANAVISAGAGAGLAAAFNTPLSGIIFVIEEMNRK 197

Query: 178 SEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAG 237
               +   +   L+A     + +        ++ +  +  +    +    ++  I    G
Sbjct: 198 FRFSVS-AIKCVLVACIMSTVISRAIMGNPPAIRVETFSSVPQNTLWLFMVLGIIFGYFG 256

Query: 238 MVAVWCLPRLHAMMHQ-MKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAF 296
           ++    L ++     +  K     L I   I+  +GV+  P ++  G   +   + +   
Sbjct: 257 LLFNKSLIKVANFFSEGSKKRYWTLVIIVCIIFGIGVVLSPNAVGGGYIVIANTL-DYNL 315

Query: 297 STSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVP------AAI 350
           S     +L V++ A ++ +  +G  GG   P + +G   GL     V  +         +
Sbjct: 316 SIKMLLVLFVLRFAGVIFSYGTGVTGGIFAPMIALGTVFGLAYGLSVEQLFPQYNIEPGV 375

Query: 351 TVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNRPK 410
                +  +           + +   +  N  LL  L I    A +L      +   +P 
Sbjct: 376 FAVAGMSALFTATVGAPLTGIVLVMEMTWNFHLLLPLMITCFSASMLT----YIHHQKPI 431

Query: 411 QQP 413
              
Sbjct: 432 YDT 434


>UniRef50_A0LKT1 Cl-channel, voltage-gated family protein n=1 Tax=Syntrophobacter
           fumaroxidans MPOB RepID=A0LKT1_SYNFM
          Length = 612

 Score =  215 bits (547), Expect = 4e-54,   Method: Composition-based stats.
 Identities = 74/424 (17%), Positives = 134/424 (31%), Gaps = 29/424 (6%)

Query: 10  LLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGT-------------LGIAQDSP 56
           +     +VAIGI S L+   V  +         + L G              +       
Sbjct: 38  VRWGFYSVAIGILSGLMACAVFALLEWTSFFCLEYLAGYAVAKPAGEHLVDLVADTPLRR 97

Query: 57  LWIIGVLTLTGIAVGLVIR-FSQGHAGPDPACE----PLIGAPVPPSALPGLIVALILGL 111
             +  +    G+  GL++  ++    G                +         +A ++ L
Sbjct: 98  WVLFLLPAFGGLLSGLIVYTWAPEAEGHGMDAFIDAFHNKSGHIRTRVPFVKGIASVITL 157

Query: 112 AGGVSLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIF 170
           + G S G E PI  +   +   +G    L    R    +   A  +GA+F  P+  AL  
Sbjct: 158 STGGSAGREGPIAQIGAGIGSCLGRAFHLTARERRLMLLAGCAAGLGAIFRAPLGGALTA 217

Query: 171 SQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVA 230
            + L           L   ++++  G       F                 ++L   I+A
Sbjct: 218 IEVLYREDFEAEGIVL--CIISSVTGYAIFTAIFGHEPIFETTALPFSNPVELLFYGILA 275

Query: 231 AIAIAAGMVAVWCLPRLHA-MMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQ 289
            I +  G   V     L   +  ++    + +   G +L  L  +  P  L  G   +QQ
Sbjct: 276 LICVPFGYAYVKIFYGLRDHLFRRLPLKRVFVPALGGLLVGLLGLFAPQVLSGGYGTIQQ 335

Query: 290 MVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAA 349
            +  +  S     LLA +K+ A     +SG  GG   P++F+G  LG  + +        
Sbjct: 336 ALKGE-VSAGLLLLLAALKIVATSFTISSGGSGGVFGPSLFIGAMLGGAVGQLSHEWFPT 394

Query: 350 I------TVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPM 403
           +           +      V +    +L M   +     L+  L    + A LL     +
Sbjct: 395 LVTQPGGFALVGMGAFFAGVAKAPIGALLMVCEMTGGYGLVVPLMFTSVVAILLSQRWSL 454

Query: 404 MMVN 407
               
Sbjct: 455 YEKQ 458


>UniRef50_C8X3C6 Cl-channel voltage-gated family protein n=1 Tax=Desulfohalobium
           retbaense DSM 5692 RepID=C8X3C6_DESRD
          Length = 597

 Score =  214 bits (546), Expect = 4e-54,   Method: Composition-based stats.
 Identities = 80/403 (19%), Positives = 159/403 (39%), Gaps = 17/403 (4%)

Query: 10  LLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLW-IIGVLTLTGI 68
           + L   AVAIG  +++  ++        Q LLW      +   Q +P W ++ V TL G+
Sbjct: 26  ISLLGFAVAIGFLAAVGALLFRSCIEGFQFLLWPGGASLVEQVQAAPWWMVLLVPTLAGL 85

Query: 69  AVGLVIRFS--QGHAGPDPACEPLIGAP---VPPSALPGLIVALILGLAGGVSLGPEHPI 123
            VG VI F   +      P     +      +         +   L LA G S+G E PI
Sbjct: 86  VVGPVIAFFVPEARGPGVPEVILSVTTRQSTIRHRVTFLKGLITSLLLAAGASVGREGPI 145

Query: 124 MTVNIALAVAIGARLLPRVNRMEW-TILASAGTIGALFGTPVAAALIFSQTLNGSSEVPL 182
           + +  ++  ++      R           +A  I A F  P+A +L   + +  + EV  
Sbjct: 146 VQIGSSVGSSLAQFFGLRPELRRLCLACGAAAGIAATFNAPIAGSLFALEIILMNIEVSY 205

Query: 183 WDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVW 242
              +   ++AA  G++ + +F+    +  +  +     +++L   ++  +A    +V V 
Sbjct: 206 ISHI---VIAAITGSVLSRIFWGDFPAFRVVPFELGSYSELLGYLVLGILAGLVSIVFVR 262

Query: 243 CLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYF 302
            +     +  +++ P  +    G +L     +  P  +  G + +   +AN +       
Sbjct: 263 SIFATENIFQRLRLPQWLSPAIGGLLLGCLALSLPQVMGVGYETVNDALAN-SLPLQMAL 321

Query: 303 LLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHE----HVPA--VPAAITVSCAI 356
           +L   KLAA  +   SG  GG   P++F+G ALG ++        PA  +  A      +
Sbjct: 322 VLLAAKLAATAICIGSGMSGGIFAPSLFLGAALGTVVGLGATVVWPAHDLHPAFFALAGM 381

Query: 357 LGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLA 399
             +V   T     ++     +  +  ++  L +  + A L++ 
Sbjct: 382 GAVVSGTTLAPITAIVTIFELTLHYQIILPLMVACISATLVVR 424


>UniRef50_Q1MXQ9 Chloride channel protein EriC n=1 Tax=Bermanella marisrubri
           RepID=Q1MXQ9_9GAMM
          Length = 584

 Score =  214 bits (546), Expect = 5e-54,   Method: Composition-based stats.
 Identities = 57/410 (13%), Positives = 126/410 (30%), Gaps = 18/410 (4%)

Query: 12  LSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVG 71
           L++  +  G+ +S I+++         +            A +  + +   +    + + 
Sbjct: 21  LAMLGIVAGLLTSGIILLFRLAIEHSLSGFLGMPHHEAFEALNPLVRMTLPMMGALLLIA 80

Query: 72  LVIRFSQGH----AGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVN 127
           L  + S                     +P S L       I+    G S G E P + + 
Sbjct: 81  LFYKVSAKARQVGISHVLERLKNHQGHMPMSNLFVQFFGGIICAISGQSTGREGPAVHLG 140

Query: 128 IALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRL 186
            A    +  +L +   +         A  I A F TP+A  +   + +        +  L
Sbjct: 141 AAAGSIMSRKLQMTSSHTQLLLACGVAAAISASFNTPIAGVIFAMEVIVMGYS---FLSL 197

Query: 187 FAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPR 246
              ++A+  GAL T   +    +  +       + +     +   +  A   + +W    
Sbjct: 198 IPVILASVTGALVTRAVYGSEPAFNVPALQMNSLLEAPFLIVEGLLMGALAAMFIWV--- 254

Query: 247 LHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAV 306
                 +      +  +   +L  +  +  P  +  G D +   +          F+ A+
Sbjct: 255 CVNTAKKAPQSFTIRLLLIGVLNGVLALLIPAVMGIGYDTVNAALLGN-LPWIALFIFAM 313

Query: 307 IKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPA------AITVSCAILGIV 360
            KL    +    G  GG I P +F+G   G ++ E                    +  ++
Sbjct: 314 AKLLITSLNLGLGQPGGAIGPMLFIGACAGGVIGEIGNQFAPDIAGSTGYYAMLGMAAMM 373

Query: 361 LVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNRPK 410
               +    +L     +  N  +L    +V++ A L  +         P+
Sbjct: 374 SACLQAPLTALMTLLELTNNPNILLPAMLVVVIANLTASEIFKQKALFPR 423


>UniRef50_A4YDN2 Cl-channel, voltage-gated family protein n=19 Tax=cellular
           organisms RepID=A4YDN2_METS5
          Length = 588

 Score =  214 bits (546), Expect = 5e-54,   Method: Composition-based stats.
 Identities = 75/441 (17%), Positives = 149/441 (33%), Gaps = 37/441 (8%)

Query: 11  LLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPG-------------TLGIAQDSPL 57
              +  + +G+ +     V   +  V + +   R  G                    + +
Sbjct: 13  KWLILGILLGVVAGFASTVFYLLLHVFEYIFITRFVGMSYPHPLGEGGTLNFTFHPGNFI 72

Query: 58  WIIGVLTLTGIAVGLVIR-FSQGHAGPD----PACEPLIGAPVPPSALPGLIVALILGLA 112
            +   L + G+  GLV+  F+    G            +   V    +P  I A  + + 
Sbjct: 73  LVPVSLMIGGLISGLVVYTFAPEAEGHGTDAAIKAYHYLQGKVRWVVIPVKIFASAVTIG 132

Query: 113 GGVSLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFS 171
            G S G E P    +  +   I   L L   +R     +     IG +F TP+  AL+ S
Sbjct: 133 SGGSAGREGPTAQFSSGVGSVIADLLKLSPEDRRRALAVGIGAGIGTIFKTPIGGALLAS 192

Query: 172 QTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAA 231
           + L      P  + ++  L+A++ G    G+ F         + G      +   A++  
Sbjct: 193 EILYKRDLEP--ELIYPGLIASSVGYTIFGIIFGFTPVFG-YYTGTFNPMRLPLYALLGV 249

Query: 232 IAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMV 291
           I+    ++ V     +  +  ++K P  V  + G  L  L  +  P  +  G   +    
Sbjct: 250 ISGLLAILYVKSFYGISGLFKRLKLPNHVKPMIGGGLAGLLTLLFPEVMGTGYGWINLAE 309

Query: 292 ANQAFST--------SDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHV 343
             +  S             LL ++K+ A  ++  SG  GG   P +F+G  LG  +    
Sbjct: 310 FERFSSFYSPVLPVLLLLALLPLVKILATSLSIGSGGSGGVFAPGLFIGAFLGADVGLIF 369

Query: 344 PAVPAAI------TVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLL 397
             +  ++       V   ++       +     + M   +  +  LLP   I +  ++L+
Sbjct: 370 HYLFPSLVPNIAPFVIIGMMSFFAAAGKVPLSVIVMVTEMTSSLQLLPGAMIAVAISYLV 429

Query: 398 LAGKPMMMVNRP-KQQPPHDN 417
                +     P ++  P   
Sbjct: 430 SGNYTIYRSQVPTRRDSPAHK 450


>UniRef50_C4ZAT1 Chloride channel protein EriC n=9 Tax=Bacteria RepID=C4ZAT1_EUBR3
          Length = 423

 Score =  214 bits (545), Expect = 5e-54,   Method: Composition-based stats.
 Identities = 64/412 (15%), Positives = 148/412 (35%), Gaps = 27/412 (6%)

Query: 3   HPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGV 62
             R  T +   + ++ +GI +           SV+ +   +              W+I  
Sbjct: 17  TKRLITSIKWVIFSIVVGIVAGSCGTAFYFALSVVTDFRMKYP------------WLIYF 64

Query: 63  LTLTGIAVGLVIRFSQGH--AGPDPACEPLIGA-PVPPSALPGLIVALILGLAGGVSLGP 119
           L + G+A+  +    +     G +     +     VP    P + V+ ++    G S G 
Sbjct: 65  LPIGGLAIVGLYHLCKDDNDTGTNLVISAIHSGDKVPFIMAPLIFVSTLITHLFGGSAGR 124

Query: 120 EHPIMTVNIALAVAIGARLLPRVNRM-EWTILASAGTIGALFGTPVAAALIFSQTLNGSS 178
           E   + +  ++  +IG              +   +    ALFGTP+AAA+   + +  S 
Sbjct: 125 EGAALQMGGSIGSSIGRVFRFDEKDKHVMIMCGMSAAFSALFGTPMAAAIFSMEMI--SV 182

Query: 179 EVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGM 238
            V  +  L   ++++         F   +    I +     + + +  +++A +     +
Sbjct: 183 GVMYYIALVPCVISSLIAHGIASYFNVTNEFFAIENIPDFTILNSVKISVLAILCALVSI 242

Query: 239 VAVWCLPRLHAMMHQ-MKNPVLVLGIGGFILGILGVIGGPVSL-FKGLDEMQQMVANQAF 296
           +    L    A+  + + N    + IGG  + I  ++ G  +    G+  +Q  +     
Sbjct: 243 LFCVALHSGEALYKKYLPNKYTRVFIGGCFIIIATMLVGNQTYNGTGMSVIQSSIDGSVR 302

Query: 297 STSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAI 356
             +        K+    +   +GF+GG I P+ F+G   G +        P ++  +  +
Sbjct: 303 PEAFLL-----KIIFTALTLGAGFKGGEIVPSFFIGATFGCLFGNLTGFEP-SLCTAVGM 356

Query: 357 LGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNR 408
           + +   VT     SL ++  +      +P   + +  +++L     +    +
Sbjct: 357 ISLFCGVTNCPITSLLISFELFG-YDGMPYFLLAIPFSYMLSGYFGLYRSQK 407


>UniRef50_B0SCJ7 Chloride channel protein n=2 Tax=Leptospira biflexa serovar Patoc
           RepID=B0SCJ7_LEPBA
          Length = 604

 Score =  213 bits (544), Expect = 7e-54,   Method: Composition-based stats.
 Identities = 70/430 (16%), Positives = 141/430 (32%), Gaps = 36/430 (8%)

Query: 12  LSLPAVAIGIASSLILIVVMKIASVLQNLLWQRL--------------PGTLGIAQDSPL 57
           + + ++ IG+ S           +  ++  +  L                   +A  SPL
Sbjct: 19  IYVFSLLIGLLSGFGAYGFNWALTWTESFTFGNLIGYDPGTPAGDLNFHSVGTVAVLSPL 78

Query: 58  WIIGVLTLTGIAVGLVIRFS---QGHAGPDPACEPLI--GAPVPPSALPGLIVALILGLA 112
           WI+ +  + G+ VG++  F        G D            +         +A IL L 
Sbjct: 79  WILFLPAIGGLLVGIITSFFCPEAQGGGTDSLIHSFHFNEGKIHTKVPFFKAIATILTLG 138

Query: 113 GGVSLGPEHPIMTVNIALAVAIGARLLPRVN-RMEWTILASAGTIGALFGTPVAAALIFS 171
            G S G E P   +      ++   L      R    +  +AG +GA+F  P+  A+   
Sbjct: 139 SGGSGGKEGPTAQIGAGFGSSLANFLGAGARARRTLMLAGTAGGLGAIFRAPLGGAITAV 198

Query: 172 QTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAA 231
           + +         D L   ++++    LT            +  Y   +   I    ++  
Sbjct: 199 EMVYQEDIE--SDSLVPCILSSVTAYLTYTSIAGSGSIFSVQEYSLNDYRHIPLYIVLGL 256

Query: 232 IAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMV 291
           +    G   V     +  +  ++  P  +    G ++     +  P  L  G   +Q+M+
Sbjct: 257 LCYVVGYFFVKVYHFVQDIFSKLPLPNYLKPAFGGLIVGCIALLFPEVLGSGFGLIQRMI 316

Query: 292 ANQAFS--------TSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHV 343
             +  +              +A+ K+ +  +   SG  GG + P+  +G  LG  +    
Sbjct: 317 NGEVLTSTSFGFSGPFFLLAVAIFKVFSTSLTVGSGSSGGLLGPSFAIGGMLGAFVGTMA 376

Query: 344 PAVPAAI------TVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLL 397
             +   +       +   +      V R     + M   ++ +  LLP L IV + A +L
Sbjct: 377 NVLFPELNIIVFPFLLVGMGSFFAGVARAPIAGMIMVCDMIGSYALLPALMIVSMIAVVL 436

Query: 398 LAGKPMMMVN 407
                +    
Sbjct: 437 SHKISIYRNQ 446


>UniRef50_B2J0T5 Cl-channel, voltage-gated family protein n=10 Tax=Cyanobacteria
           RepID=B2J0T5_NOSP7
          Length = 883

 Score =  213 bits (544), Expect = 7e-54,   Method: Composition-based stats.
 Identities = 66/414 (15%), Positives = 138/414 (33%), Gaps = 25/414 (6%)

Query: 2   LHPRARTMLL-----LSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSP 56
           ++ R RT            A  IG+ ++L  +       V    L      T  +     
Sbjct: 1   MNQRFRTWWQPRRGLAIAEACVIGLVAALSAVF----LKVGSGWLGTWRVHTTHLFPAWL 56

Query: 57  LWIIGVLTLTGIAVGLVIRFSQGHAGP-DPACEPLIGA---PVPPSALPGLIVALILGLA 112
           +  +  L L  IA  LV R +    G   P  +  +      +        +++ I+ + 
Sbjct: 57  VLPVIGLVLGFIAGWLVDRLAPEAYGSGIPQVKASLANVPVNLSWRVAGVKLLSAIIAIG 116

Query: 113 GGVSLGPEHPIMTVNIALAVAIGARLLPRVN-RMEWTILASAGTIGALFGTPVAAALIFS 171
            G++LG + P + V   LA  +   +    + R +     +   + A F  P+A  L   
Sbjct: 117 SGMTLGRQGPTVQVGAGLAAGMSRWVPTSPDHRRQMIAAGAGAGLAAAFNAPIAGVLFIV 176

Query: 172 QTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPI---AHYGQMEMTDILSGAI 228
           + L           L   ++A+  G + + L     F L +       Q  + +I    +
Sbjct: 177 EELLQDLS---GLTLGTAIIASFIGGVISRLLGGGSFDLNLQLTQSSSQFSIPEIPFFVL 233

Query: 229 VAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQ 288
           +  +A   G +    L        ++   + +       +  + V   P S        +
Sbjct: 234 LGILAGLLGALFNSGLIFSIKFYRRLHISLPLRVALAGFISGVVVAMLPPSFRDNTGLRE 293

Query: 289 QMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHE----HVP 344
            ++   +  T         +    ++A  SG  GG   P++ +G  LG ++         
Sbjct: 294 SLITGGSHPTVAAIAFT-AQFILTLIAFGSGAPGGLFAPSLILGSCLGHIIGVAELYITG 352

Query: 345 AVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL 398
                      + G    V++    ++ +   +  +  L+  L IV + A+L+ 
Sbjct: 353 VGSPTTYALAGMGGFFSAVSKVPITAIVIVFEMTTDFNLVLPLMIVSVAAYLVA 406


>UniRef50_C1SIP9 Chloride channel protein EriC n=1 Tax=Denitrovibrio acetiphilus DSM
           12809 RepID=C1SIP9_9BACT
          Length = 595

 Score =  213 bits (544), Expect = 8e-54,   Method: Composition-based stats.
 Identities = 70/430 (16%), Positives = 137/430 (31%), Gaps = 28/430 (6%)

Query: 11  LLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGT-------------LGIAQDSPL 57
              +    +G+ S +  I+   +           L G                  +    
Sbjct: 14  RWFILGSIVGLVSGVGAIIFFLLLQGSSFFFMDYLMGIRVEETGGEHALFGHAATEFRRW 73

Query: 58  WIIGVLTLTGIAVG-LVIRFSQGHAGPD----PACEPLIGAPVPPSALPGLIVALILGLA 112
            I+ V  L G+  G LV +F+    G                +          A  + + 
Sbjct: 74  SILLVPALGGLISGFLVYKFAPEAEGHGTDAAIKAIHFKNGSIRWRVPIIKTFASAITIG 133

Query: 113 GGVSLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFS 171
            G S G E PI  +       +G  L L    R   T       +GA+F +P+A A+  +
Sbjct: 134 TGGSGGREGPIAQIGAGFGSFLGTTLKLSERERRILTAAGMGAGVGAIFRSPLAGAIFAA 193

Query: 172 QTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAA 231
           + L  SS++  ++ L    + +          +          +      +++  +++  
Sbjct: 194 EVLYASSDME-YEALLPSAITSIIAYSVFCSVYGWEPLFATPDFAFENPVELIGYSVLGF 252

Query: 232 IAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMV 291
                G + V     +H +  QM     +  + G  L        P +L     +++  +
Sbjct: 253 ACAVFGWLYVRTFYGIHGIFKQMHISPYIKPVIGGFLTGCVGFFVPQALAGSYAQIELGM 312

Query: 292 ANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAV----- 346
             Q       F+L   K+     +  SG   G   P++ +G A+G  +   + +      
Sbjct: 313 QGQ-LGIGFIFILIFAKILTTSFSIGSGGSAGIFGPSMVIGAAVGGFVGLALNSFVPFIA 371

Query: 347 -PAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMM 405
                 V   + G    +      ++ M + +  N  LL     V   A+LLL    M +
Sbjct: 372 PEPGAYVIVGMAGFFSGIANTPLSTIIMVSEMTGNYHLLVPSMWVSTLAFLLLRKTTMYV 431

Query: 406 VNRP-KQQPP 414
              P + + P
Sbjct: 432 NQVPMRSESP 441


>UniRef50_Q040F7 Chloride channel protein EriC n=29 Tax=Lactobacillus
           RepID=Q040F7_LACGA
          Length = 534

 Score =  213 bits (543), Expect = 9e-54,   Method: Composition-based stats.
 Identities = 74/427 (17%), Positives = 151/427 (35%), Gaps = 23/427 (5%)

Query: 6   ARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTL 65
            ++ L L L A+ +G+ + +++              W  L           + I+  L L
Sbjct: 22  EKSNLKLMLQALCVGLIAGVVVGFFRYGIGK-TEAFWLDLFKKSHQNPLWFIVIVAGLAL 80

Query: 66  TGIAVGLVIRFSQGHAGP-DPACEPLIGAPVPPSAL---PGLIVALILGLAGGVSLGPEH 121
           TGI  G  ++      G   P  +  +   +           ++  I+ +  G+ LGPE 
Sbjct: 81  TGIIAGYFVKQYPHVGGSGIPEVKLQMQGKLTLQWWPILWRKLIGGIMVIGTGLFLGPEG 140

Query: 122 PIMTVNIALAVAIGARLL-PRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEV 180
           P + +   +   +G      + N        +A  + A FG P++ AL   + +  +   
Sbjct: 141 PSLQLGSTIGQGVGQGFKQTKTNSRVLLATGAASGLSAAFGAPLSGALFVLEEIFHNFSP 200

Query: 181 PLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVA 240
            +W      L+ A A        F    +L +A+     M       ++  I    G + 
Sbjct: 201 RVW---MNALVGAIASNFVVSNLFGQKPALALAYNHSFPMPLYWHLVLLGLILGLLGHLY 257

Query: 241 VWCLPRLHAMMHQMK-NPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFS-- 297
              L  L     ++   P  + G+   ++ +  +   P+    G   +  +  + A+S  
Sbjct: 258 KLGLFNLKKFYAKITFIPRWLHGLIPLVILMPIMYYLPLITGPGNHLILSLPKSIAYSSW 317

Query: 298 --TSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEH------VPAVPAA 349
                  +  VI++A  +V+  SG   G   P + +G  +G            +P     
Sbjct: 318 NLVGMLAIFYVIRIAFSIVSYDSGLPSGIFLPILTMGALIGATYGLFMVQLGLLPQKLVI 377

Query: 350 ITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLL---LAGKPMMMV 406
             +  A+ G    + R  + ++ +   +V +   L  L +V   A L+   L G+P+   
Sbjct: 378 NLIIFAMAGYFAAIIRAPFTAIILITEMVGSLLHLMPLAVVAFIALLVDQLLGGRPIYDS 437

Query: 407 NRPKQQP 413
                +P
Sbjct: 438 LAAAMEP 444


>UniRef50_Q3MBC4 Cl-channel, voltage gated n=7 Tax=Bacteria RepID=Q3MBC4_ANAVT
          Length = 434

 Score =  213 bits (543), Expect = 9e-54,   Method: Composition-based stats.
 Identities = 82/411 (19%), Positives = 160/411 (38%), Gaps = 17/411 (4%)

Query: 11  LLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAV 70
              L  V +G    L   +   +  ++ +           + +   + ++ V+ + G+ V
Sbjct: 33  RWVLRWVMVGTVCGLFAGLYWNVLELMTH----------QLERFESVSLLIVMPIAGLIV 82

Query: 71  GLVIRFS--QGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNI 128
           GLVI F    G            G  +     P +I+A ++ +AGG S GPE P++ V  
Sbjct: 83  GLVIHFLGNPGEIAVIVDNIHFRGGRLDIRKNPAMILASLVSIAGGGSAGPEAPLVQVTG 142

Query: 129 ALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLF 187
           +    +G RL L   +    ++ A A    ALFG P+  A+   + L+    +  ++ L 
Sbjct: 143 SFGTWVGDRLGLQGEDMRSMSLAAMAAGFTALFGAPLGGAMFALEILHHQHIIEYYEALM 202

Query: 188 APLMAAAAGALTTGLF--FHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLP 245
             ++++ A  L   L        +     Y    M D     +   I   AG + +    
Sbjct: 203 PAIVSSCASYLVFALITHLGIAPTWHFPEYNLENMDDFAWAILFGIIGAVAGWIFMTIFR 262

Query: 246 RLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLA 305
               +   +  PV +      +      I  P++ + G  E++ ++ N  FS     +LA
Sbjct: 263 TCDRLWAMLPVPVYIRTTLAGLGLGTLAIFLPLTRYFGHQELESVL-NTNFSVVFLLILA 321

Query: 306 VIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLVVTR 365
           + K+A++ +    G+RGG I P  F G  +G  +   +P +   + + C +  +   VTR
Sbjct: 322 LGKMASISLTVTGGWRGGFIIPLFFTGACVGKAIAILIPGLNPTLAMICTMSALNAGVTR 381

Query: 366 DGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNRPKQQPPHD 416
               +  + + +  N +    +    L  + L    P++      QQ   +
Sbjct: 382 TPISTTLLLSKLT-NFSPFTPILFASLIGFFLAPKVPLIASQLKSQQSIEE 431


>UniRef50_D0BLG2 Voltage-gated chloride channel protein n=1 Tax=Granulicatella
           elegans ATCC 700633 RepID=D0BLG2_9LACT
          Length = 521

 Score =  213 bits (542), Expect = 1e-53,   Method: Composition-based stats.
 Identities = 65/412 (15%), Positives = 137/412 (33%), Gaps = 21/412 (5%)

Query: 22  ASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRFSQGHA 81
                + +           +           Q  P+WI+  + +  I   +V        
Sbjct: 30  LVGTTVSLFRLFLGKTLEGVIVVYSYLQESPQWLPVWIVFSMIMAVILGQIVKSEPDIKG 89

Query: 82  GPDPACEPLIGAPVPPSAL---PGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARL 138
              P  E  +   +  +         VA  + +  G+ LG E P + +  ++A  +   L
Sbjct: 90  SGIPQVELQLQGKMDMNWWSVCWKKFVAGFISIGSGLLLGREGPSIQLGASVAQGVAEGL 149

Query: 139 LP-RVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGA 197
              RV +  +    +   + A F  P+A  +   + ++ +            L AA    
Sbjct: 150 KSNRVQKNIFISSGAGAGLAAAFNAPIAGLMFVLEEVHHTFSP---LVALTTLTAAIVSN 206

Query: 198 LTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQM--K 255
             +   F    SL + +     M+      ++  +    G V      +L A+  ++   
Sbjct: 207 FVSLNIFGARPSLNLGNDQIFPMSHYGYVILLGIVLGLFGWVYHHYTLQLPAIYGKLFPF 266

Query: 256 NPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVA 315
            P     +  FI  I   +  P  L  G + + +++     +      L +++L   +++
Sbjct: 267 IPNYYYCMVAFIAIIPLGLWNPHVLGGGGEMILELLHENH-TVQFLAFLFILRLFYSMLS 325

Query: 316 AASGFRGGRIFPAVFVGVALGLMLHEHVPAVPA------AITVSCAILGIVLVVTRDGWL 369
             +G  GG   P + +G  LGL+  E +              V  A+ G    + +    
Sbjct: 326 YGTGLPGGIFLPILSLGALLGLVYAEVLIQFFGVDPSLRVSFVFFAMAGYFSAIGKAPLT 385

Query: 370 SLFMAAVVVPNTTLLPLLCIVMLPAWLLL-----AGKPMMMVNRPKQQPPHD 416
           +L +   +V     L  L I  L A+++           ++  R   + PH+
Sbjct: 386 ALLLVTEMVGGLNQLMPLGICTLTAYIVADYLKMGPIYEILAERLDSEHPHE 437


>UniRef50_Q2S8Y1 Chloride channel protein EriC n=4 Tax=Gammaproteobacteria
           RepID=Q2S8Y1_HAHCH
          Length = 601

 Score =  212 bits (541), Expect = 1e-53,   Method: Composition-based stats.
 Identities = 57/411 (13%), Positives = 136/411 (33%), Gaps = 23/411 (5%)

Query: 11  LLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAV 70
            L+L     G+A+ +++++      +    L           Q +PL    +  +  + +
Sbjct: 40  QLALLGFLSGLATGVVILLFRAAIELPLGYLLPG-DSAENFEQLTPLMQFCLPIVGALIL 98

Query: 71  GLV-----IRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMT 125
            L      ++  +                +   +        +  LA G S G E P + 
Sbjct: 99  ALWLMRLGVQQRKVGVTHVMERLGYHQGYISLRSGLLQFFCGVATLATGQSAGREGPAVH 158

Query: 126 VNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWD 184
           +    +  +G  + LP  +        +A  + A F TP+A  +   + +     +  + 
Sbjct: 159 LGATSSSLLGQWMGLPNNSIRMLVGCGTAAAVSASFNTPIAGVIFAMEVVMLEYTINGFT 218

Query: 185 RLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCL 244
                ++AA   A+ +   +    +  + ++    + ++     VA +      + V  +
Sbjct: 219 ---PIILAAVTAAVVSQPIYGNDPAFIVPNFSLNSLVELPYIVAVAILIGMCSALFVKII 275

Query: 245 PRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLL 304
            +    M ++K P+L   +    L  L  +  P  +  G D +   +A           +
Sbjct: 276 SQT---MEKVKTPILCRLLAAGFLTGLAALALPQIMGIGYDTVNDAIAGN-IGFLLLLAI 331

Query: 305 AVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAV------PAAITVSCAILG 358
           A+ KL         G   G I P +F+G  LG  L      +               +  
Sbjct: 332 ALAKLLVTATTIGLGMPSGIIGPTLFIGATLGGALGVLANMLMPTLASEPGFYAVLGMGA 391

Query: 359 IVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNRP 409
           ++  V +    ++     +  N  ++    ++++ + L+ +        R 
Sbjct: 392 MMGSVLQAPLAAIMAVIELTRNPNVILPAMLIIIVSSLIASH---YFRQRS 439


>UniRef50_C1F836 Chloride transporter, ClC family n=1 Tax=Acidobacterium capsulatum
           ATCC 51196 RepID=C1F836_ACIC5
          Length = 584

 Score =  212 bits (540), Expect = 2e-53,   Method: Composition-based stats.
 Identities = 73/404 (18%), Positives = 149/404 (36%), Gaps = 14/404 (3%)

Query: 7   RTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLT 66
           R   L  + ++ IG+ S L+++        ++ L     P          +  +  L + 
Sbjct: 34  REERLFLVLSIFIGVISGLLVVAFRSAYEWIKILALGSAPHPGQYR-LMYMPALVGLVVA 92

Query: 67  GIAVGLVIRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTV 126
            + V L             A   +    +    + G  +   L +  G SLGPE P + +
Sbjct: 93  SLVVWLFPGARGSGVNQTKAALYVYNGYISFKTVIGKFITAALAIGSGQSLGPEDPSLQI 152

Query: 127 NIALAVAIGARLLPRVNR-MEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDR 185
              +A  I  RL     R   +  + +A  + A F  P++A L   + + GS        
Sbjct: 153 GAGVASMIARRLRMSRQRLRMFAPIGAAAGLAAAFNAPISAILFVIEEVIGSWSAA---V 209

Query: 186 LFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLP 245
           L + ++AA +  +   LF+       +      +  ++L+ A++        ++    L 
Sbjct: 210 LGSVVLAAISSEVVARLFWGSEPMFHVPPVELRDPRELLAYAVLGVTGGFLAVIFSKALG 269

Query: 246 RLHAMMHQMKNP--VLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFL 303
            L  +M  +      +   I G ++G +G  G P  +  G   + Q + +  F+      
Sbjct: 270 YLRPVMRNLPRWTHFVQPAIAGLLVGAIGFFGFPQVMGPGYTVIDQAL-HAEFTWKILLA 328

Query: 304 LAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPA------AITVSCAIL 357
           LA++K+ A  ++ +SG  GG   P +F+G  LG  +                      + 
Sbjct: 329 LALLKMLATALSFSSGTPGGMFAPTLFIGAMLGGAVGTFEHHFFPHLVGTVGAYALVGMG 388

Query: 358 GIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGK 401
            +     R    S+FM   +  N++++  + +    A+L+    
Sbjct: 389 VLFAGFLRVPLTSVFMVLELSGNSSIILPVVLANTIAYLISRSL 432



 Score = 42.5 bits (99), Expect = 0.033,   Method: Composition-based stats.
 Identities = 24/218 (11%), Positives = 57/218 (26%), Gaps = 27/218 (12%)

Query: 17  VAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRF 76
             +G+    + ++  K    L             +             + G+ VG +  F
Sbjct: 251 AVLGVTGGFLAVIFSKALGYL----------RPVMRNLPRWTHFVQPAIAGLLVGAIGFF 300

Query: 77  S------QGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIAL 130
                   G+   D A        +  +     ++A  L  + G   G   P + +   L
Sbjct: 301 GFPQVMGPGYTVIDQALHAEFTWKILLALALLKMLATALSFSSGTPGGMFAPTLFIGAML 360

Query: 131 AVAIGARLLPRVNRME-----WTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDR 185
             A+G         +      + ++            P+ +  +  +    S        
Sbjct: 361 GGAVGTFEHHFFPHLVGTVGAYALVGMGVLFAGFLRVPLTSVFMVLELSGNS------SI 414

Query: 186 LFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDI 223
           +   ++A     L +             H   +E+  +
Sbjct: 415 ILPVVLANTIAYLISRSLQPTPIFEVFTHQDGLELPSM 452


>UniRef50_UPI0001C33F57 chloride channel protein n=2 Tax=Enterobacteriaceae
           RepID=UPI0001C33F57
          Length = 466

 Score =  211 bits (539), Expect = 3e-53,   Method: Composition-based stats.
 Identities = 75/412 (18%), Positives = 139/412 (33%), Gaps = 21/412 (5%)

Query: 5   RARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLT 64
           R +T L + L A  +G  + L+ +   +  + + N     + G         +W  G+  
Sbjct: 28  RDKTPLAILLAAAVVGTVAGLLGVAFERAVNSVLNWRIGTIAGYADREWLVWVWAFGLSA 87

Query: 65  LTGIAVGLVIRFSQGHAGP--DPACEPLIGAPVP---PSALPGLIVALILGLAGGVSLGP 119
           L  +    ++R     AG    P  E  +    P      +P   +  +  L  G+ LG 
Sbjct: 88  LLAMVGYFLVRKFAPEAGGSGIPEIEGALEEMRPVRWWRVIPVKFIGGMGTLGAGMVLGR 147

Query: 120 EHPIMTVNIALAVAIGA--RLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGS 177
           E P + +   +   IG   R+     R       +A  + A F  P+A  L   + +   
Sbjct: 148 EGPTVQLGGNVGRMIGDLFRMRSAEARHTLLATGAAAGLSAAFNAPLAGILFIIEEMRAQ 207

Query: 178 SEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAG 237
               L   + A        ++   +F      + +       +  +    ++  I    G
Sbjct: 208 FRYNL-ISIKAVFTGVIMSSIVFRIFNGEGAVIEVGKLTNAPVNTLWLYLVLGMIFGVVG 266

Query: 238 MVAVWCLPRLHAMMHQMK-----NPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVA 292
            +    + R   M  ++        VLV G+ G   GILG    P ++  G   +   VA
Sbjct: 267 PLFNTLILRAQDMFQRIHGGNTTKWVLVGGLLGGACGILG-FIEPNAVGGGFGLIPIAVA 325

Query: 293 NQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAI-- 350
              FS      + + ++   V+  +SG  GG   P + +G  LG        +   A   
Sbjct: 326 GN-FSVGLLLFMFISRVITTVLCFSSGAPGGIFAPMLALGTLLGTAFGMAAASGFPAYHL 384

Query: 351 ----TVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL 398
                    +  ++    R     + +   +  N  L+  + I  L A LL 
Sbjct: 385 EAGTFAVAGMGALLAASLRAPLTGIVLVLEMTDNYQLILPMIITCLGATLLA 436


>UniRef50_D1U7C4 Chloride channel core n=2 Tax=Desulfovibrio RepID=D1U7C4_9DELT
          Length = 633

 Score =  211 bits (538), Expect = 3e-53,   Method: Composition-based stats.
 Identities = 79/452 (17%), Positives = 134/452 (29%), Gaps = 44/452 (9%)

Query: 5   RARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQD---------- 54
           R  T     +  V  GI S L+ +    +       +   L G +               
Sbjct: 19  RTVTSFRWLVIGVLAGILSGLVAVSFFWLVEAGTYFVQHFLAGIVSPEPAGEGIFHGPVG 78

Query: 55  --SPLWIIGVLTLTGIAVGLVIRF------SQGHAGPDPACEPLI--GAPVPPSALPGLI 104
              P  I    T TG+  G ++        + G  G D         G  +         
Sbjct: 79  EFRPWVIPVFTTGTGLFTGWLVSRFIPETIAGGTDGTDATINAFHNQGGIIRARVAIIRG 138

Query: 105 VALILGLAGGVSLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTP 163
           +  +L +A G S G E PI  +       +          R    +  +AG +GA+F  P
Sbjct: 139 ICSVLTIASGGSAGREGPITQMGAGAGSWLAKIFDFSAKERRILLLAGAAGGLGAIFRAP 198

Query: 164 VAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDI 223
           +  AL   + +         + +   +M++         FF       I  +   +  ++
Sbjct: 199 LGGALTAVEVIYREDFEA--EAILPAVMSSVVSYSIFTFFFGTDPIFGIPRFTFHDPREL 256

Query: 224 LSGAIVAAIAIAAGMVAVWCLPRLH---AMMHQMKNPVLVLGIGGFILGILGVIGGPV-- 278
              A++A +  AAG + V     +        + K  ++     G +   L  I  P   
Sbjct: 257 FFYALLALVCAAAGWMYVRTFHVIKYHIFFPLREKIGLIWSMGIGGLAMGLIGILYPHTA 316

Query: 279 --------SLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVF 330
                    L  G   ++  +  Q         L V K  A  V   SG  GG   PA+F
Sbjct: 317 TDGLITGGVLSGGYGWLELAMLGQ-IPALGMCYLIVGKTIATSVTIGSGMSGGMFAPALF 375

Query: 331 VGVALGLMLHEHVPAVPAAI------TVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLL 384
           VG   G ++ +   A    I       +   +      V       L M   +     LL
Sbjct: 376 VGGMSGGLVGKFGHAFFPDIVTQPGAYILVGMAAFFAGVASAPIGPLIMVTELTQGYGLL 435

Query: 385 PLLCIVMLPAWLLLAGKPMMMVNRPKQ-QPPH 415
             L +      +L     +       +   P 
Sbjct: 436 APLMLASALCLVLCRNVSLYEHQVDNKFDSPA 467


>UniRef50_A0LQV7 Cl-channel, voltage-gated family protein n=1 Tax=Acidothermus
           cellulolyticus 11B RepID=A0LQV7_ACIC1
          Length = 587

 Score =  211 bits (538), Expect = 4e-53,   Method: Composition-based stats.
 Identities = 74/419 (17%), Positives = 140/419 (33%), Gaps = 27/419 (6%)

Query: 8   TMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQ-------RLPGTLGIAQDSPLWII 60
           + L     A  +G  + L  +    +   +  L+            G+  +      +++
Sbjct: 43  SRLGTVAVAFLVGTGAGLGAVGFRWLIFTVTWLVTGHKEFGQAGHIGSSHLPALGVWFLL 102

Query: 61  GVLTLTGIAVG-LVIRFSQGHAGP----DPACEPLIGAPVPPSALPGLIVALILGLAGGV 115
            +  + G+  G L+ RF+    G             G  +         +A  L +  G 
Sbjct: 103 LIPAVGGLLYGPLIQRFAPEARGHGVPEVMIAVAENGGRIRSQVTVVKALASALCIGTGG 162

Query: 116 SLGPEHPIMTVNIALAVAIGARLLPRVNR-MEWTILASAGTIGALFGTPVAAALIFSQTL 174
           S+G E PI+ +  A A +IG  +    +R        +AG I A F  P+   L   + +
Sbjct: 163 SVGREGPIVQIGSAFASSIGQIVRLPESRLRILVACGAAGGISATFNAPMTGVLFGFELI 222

Query: 175 NGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTD--ILSGAIVAAI 232
                +     L   +++A    +    FF     L    +  +   D   +   ++  I
Sbjct: 223 LREFSI---GALLPIIVSAVLADIVGRAFFGSGPILSQVPHYLVLPHDMDFILVGVLGLI 279

Query: 233 AIAAGMVAVWCLPRLHAMMHQMK--NPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQM 290
           A   G+     L R+  +  ++    P       G I+  + ++  P     G   M + 
Sbjct: 280 AAVIGVGFKSALYRIEDVCDRVWGNRPEWARPAVGGIVLGVLLLALPQLYGVGYPVMDKA 339

Query: 291 VANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVP--- 347
           VA Q ++     LL V K+ A  +    G  GG   P++F+G   G         +    
Sbjct: 340 VAGQ-YALWFLLLLMVGKIVAASLTIGIGGSGGVFAPSLFIGATAGTAFGAVAEHLFGPQ 398

Query: 348 ---AAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPM 403
               AI    A+  +     R    ++     +  N TL   + + +  A  L      
Sbjct: 399 VGSPAIYGIIAMGAVFAAAARAPLTAIASVIEMTGNFTLTLPVMLAVGLAAGLSKRLTY 457


>UniRef50_C8P2F0 Voltage-gated chloride channel family protein n=1
           Tax=Erysipelothrix rhusiopathiae ATCC 19414
           RepID=C8P2F0_ERYRH
          Length = 523

 Score =  211 bits (538), Expect = 4e-53,   Method: Composition-based stats.
 Identities = 68/419 (16%), Positives = 141/419 (33%), Gaps = 18/419 (4%)

Query: 6   ARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTL 65
            +T L      + +G+ S LI+ +   +   L   +           Q   LW+   + L
Sbjct: 17  DKTRLAFIGKGIIVGVFSGLIVSLFRYLIEELLGYVKLAYALLRINPQWIFLWVFASIVL 76

Query: 66  TGIAVGLVIRFSQGHAGPDPACEPLIGAPVPPSAL---PGLIVALILGLAGGVSLGPEHP 122
                 ++ +         P  E  +   +  + L       +A IL +  G+ LG E P
Sbjct: 77  AIGIGLIIKKDPMIKGSGIPQIEGQMLGVMHMNWLSIILRKGIAGILSIGSGLFLGREGP 136

Query: 123 IMTVNIALAVAIGARLLPRV-NRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVP 181
            + +  A+   +         +        +   + A F  PVA  L   + ++ +    
Sbjct: 137 SIQLGAAVGQGVNQGFKGNTMSEKVLVSSGAGAGLAAAFNAPVAGLLFVLEEVHHNFSPL 196

Query: 182 LWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAV 241
           +     A           +  FF     L   H    ++       ++  I    G +  
Sbjct: 197 VLLTTLAAT---TTANFISLYFFGLSPILSFGHLQTFDLKHYGFIIVLGLILGVTGFIYQ 253

Query: 242 WCLPRLHAMMHQMKN-PVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSD 300
             +  +  +  ++K  P    G+  FIL I      P  +  G D +  ++    F  S 
Sbjct: 254 KTVLWIPTVYSKIKKVPAHFYGVIPFILVIPIGFFYPHLIGGGSDIIH-ILVENPFGLSV 312

Query: 301 YFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAA------ITVSC 354
              + V++    +V+  SG  GG   P + +G  LG +    + +            +  
Sbjct: 313 LISIFVLRYIFSMVSYGSGLPGGIFLPILSLGALLGAIYGSFLISQFGLDPKFLKSFIVI 372

Query: 355 AILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL---AGKPMMMVNRPK 410
           A+ G    + +    ++ +   +V N   L  + +V L A+++     G+P+      +
Sbjct: 373 AMAGYFTAIGKAPLTAIVLITEMVGNFDQLMPIAVVSLVAYVVSDLCGGEPVYEAMLER 431


>UniRef50_D1XZY9 Chloride transporter, ClC family n=2 Tax=Prevotella
           RepID=D1XZY9_9BACT
          Length = 604

 Score =  211 bits (538), Expect = 4e-53,   Method: Composition-based stats.
 Identities = 63/429 (14%), Positives = 136/429 (31%), Gaps = 33/429 (7%)

Query: 12  LSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVG 71
           + + A  +G+ +S+   V+  +   ++ LL         +     L+ +  + LT + + 
Sbjct: 33  VYILAFLVGVLASVAAYVLHTMICEIEELLTSGF-KMTNVNWLYLLYPVIGIWLTTLFIK 91

Query: 72  LVIRFSQGHAGP-DPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIAL 130
            V+R S  H             + +        IVA  + +  G S+G E PI+    A+
Sbjct: 92  YVVRDSISHGITRVLYALATNKSKIKGHNTWTSIVASAITIGFGGSVGAEAPIVLTGSAI 151

Query: 131 AVAIGARLLPRVNRMEWTI-LASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAP 189
              +G         +   +    A  + A+F  P+A  +   + L     +     L   
Sbjct: 152 GSNLGKLFKLDDRTLMLLVGCGGAAAVSAIFKAPIAGLVFTLEILMVDLTMA---SLLPI 208

Query: 190 LMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHA 249
           L+A       + LF             + ++  I +  ++        +  +  +     
Sbjct: 209 LIATVTATCFSYLFTGGSSMYAFHVDYEWQLHRIPATILLGIFCGFLSLYFMRVMTWCED 268

Query: 250 MMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQA-------------- 295
              ++        + G ++    +   P    +G D M+  +  +               
Sbjct: 269 GFGKLSKYPYTKLLVGALVLSSLIFLFPSLYGEGYDSMRVFIEGKTVEDWQSVLRGSMFA 328

Query: 296 ----FSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPA------ 345
               +      L+ + K+ A      SG  GG   P +F+G   G               
Sbjct: 329 GNAKYLVLYVGLVMITKVFATSATNGSGGCGGTFAPTLFIGGFAGFFFSRVWNMQEVGLY 388

Query: 346 VPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWL---LLAGKP 402
           VP        +  ++  V       +F+ A +     L   L IV + ++L   +     
Sbjct: 389 VPEKNFTLYGMAALMSGVMHAPLTGIFLIAELTGGYQLFIPLLIVSISSYLTINIFEHHS 448

Query: 403 MMMVNRPKQ 411
           +  +   +Q
Sbjct: 449 IYAMRLARQ 457


>UniRef50_B2TNJ2 Voltage-gated chloride channel n=19 Tax=Firmicutes
           RepID=B2TNJ2_CLOBB
          Length = 457

 Score =  211 bits (537), Expect = 4e-53,   Method: Composition-based stats.
 Identities = 49/406 (12%), Positives = 119/406 (29%), Gaps = 24/406 (5%)

Query: 8   TMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTG 67
           + L        IG  + +   + +    +   L                 W++ +L + G
Sbjct: 27  SFLKWIFIGTIIGCLTGVAGALFLNSLELATTLRNNNS------------WLLFLLPIGG 74

Query: 68  IAVGLVIRFSQGHAGP----DPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPI 123
             V  +       +                 +P      + +   +    G S G E   
Sbjct: 75  AFVSFLYSKYGKSSSKGNNLIIDKINTNNGNIPMRMASLVFLGTFVTHLLGGSAGREGTG 134

Query: 124 MTVNIALAVAIGARLLPRV-NRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPL 182
           + +  +++  +G  L     +     +   +    ++FGTP+A  +   +    +     
Sbjct: 135 VQIGSSISEGVGRLLKLDKVDTKIILMCGISSGFSSVFGTPLAGTIFGLEV--ATLGTMS 192

Query: 183 WDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVW 242
           +  L     +A  G + T  F   H    I     +    +L   I A +      +   
Sbjct: 193 YQALIPCFTSAFIGNIVTTAFGVHHSHYSILEVPTITYFVVLKIIIAAILFGLVSKLFSE 252

Query: 243 CLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYF 302
              +L  +         +  + G  + I+          +    +   + N +F+     
Sbjct: 253 LTHKLKDIFSSRFENAAIKSMVGGFIIIILTYLIGT---RDYLGLSLPLINNSFTEQVSP 309

Query: 303 LLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLV 362
                KL        +GF+GG + P   +G   G  L   +  +  +   +  ++G+   
Sbjct: 310 FAFFNKLIFTSFTLGTGFQGGEVTPLFVIGSTFGNTLSNILH-ISPSFLAALGLIGVFAG 368

Query: 363 VTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNR 408
            T     S  +   +      +  + +    ++L      + +  +
Sbjct: 369 ATNAPITSFILGLELFGAQG-IEFMFMTCAISYLFSGHSGIYISQK 413


>UniRef50_Q020M6 Cl-channel, voltage-gated family protein n=2 Tax=Acidobacteria
           RepID=Q020M6_SOLUE
          Length = 874

 Score =  211 bits (537), Expect = 5e-53,   Method: Composition-based stats.
 Identities = 67/385 (17%), Positives = 134/385 (34%), Gaps = 20/385 (5%)

Query: 40  LLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLV-IRFSQGHAGP-DPACEPLI---GAP 94
           LL +RL   L     +    + +  +   A GL+  R+     G   P  +  +      
Sbjct: 7   LLTERLGSRLYPPGGTAWRRLVIPLVGSFATGLLMFRYFPDARGSGIPQTKVALFLRDGY 66

Query: 95  VPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASA 153
           +    + G      + LA G++LG E P + V+  +A  +G RL L   +      + ++
Sbjct: 67  ISLRTVLGKFGLCSVSLASGIALGREGPSVQVSAGIASVLGRRLGLGPSSVRALIPIGAS 126

Query: 154 GTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIA 213
             + A F TP+AA L   + + G    P    L + ++++A   +   L         + 
Sbjct: 127 AALAAAFNTPIAAVLFSLEEVMGDMHAP---VLGSIVLSSATSWIVLHLVLGDEPLFHVP 183

Query: 214 HYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNP-VLVLGIGGFILGILG 272
            Y  +   +    A++        +  V  L         +      +    G +   + 
Sbjct: 184 SYQLVHPLEFGIYALLGVAGGLVSVGFVKLLLWQRKHFLSLPARTRWLQPTIGGLTVGIL 243

Query: 273 VIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVG 332
               P  L  G   + Q +  Q    +   L+ + K+ A     ASG  GG   P++F+G
Sbjct: 244 GWYFPAVLGVGYGFVGQALNGQMLIGAMALLVCL-KIVATSTCYASGNAGGIFGPSLFIG 302

Query: 333 VALGLMLHEHVPAVPAAI------TVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPL 386
             +G  +      +               +      + R    S+ M   +  + T++  
Sbjct: 303 AMMGGAVGGVAHQLLPDYTGSAGAYALVGMGAAFAGIIRVPLTSVIMIFEITRDYTIIVP 362

Query: 387 LCIVMLPAWLLLAGK---PMMMVNR 408
           L I  L ++ + +     P+    +
Sbjct: 363 LMISNLASYWISSRLQEEPIYEALQ 387



 Score = 44.0 bits (103), Expect = 0.011,   Method: Composition-based stats.
 Identities = 24/219 (10%), Positives = 61/219 (27%), Gaps = 32/219 (14%)

Query: 17  VAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRF 76
             +G+A  L+ +  +K+                              T+ G+ VG++  +
Sbjct: 197 ALLGVAGGLVSVGFVKLLLW----------QRKHFLSLPARTRWLQPTIGGLTVGILGWY 246

Query: 77  SQGHAGPDPACEPLIGAPVPPSALPG--------LIVALILGLAGGVSLGPEHPIMTVNI 128
                G        +G  +    L G         IVA     A G + G   P + +  
Sbjct: 247 FPAVLG---VGYGFVGQALNGQMLIGAMALLVCLKIVATSTCYASGNAGGIFGPSLFIGA 303

Query: 129 ALAVAIGARLLPRVNRME-----WTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLW 183
            +  A+G      +         + ++        +   P+ + ++  +          +
Sbjct: 304 MMGGAVGGVAHQLLPDYTGSAGAYALVGMGAAFAGIIRVPLTSVIMIFEI------TRDY 357

Query: 184 DRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTD 222
             +   +++  A    +           + H   + +  
Sbjct: 358 TIIVPLMISNLASYWISSRLQEEPIYEALQHQDGIHLPS 396


>UniRef50_B8G9L1 Chloride channel core n=1 Tax=Chloroflexus aggregans DSM 9485
           RepID=B8G9L1_CHLAD
          Length = 533

 Score =  211 bits (537), Expect = 5e-53,   Method: Composition-based stats.
 Identities = 66/416 (15%), Positives = 137/416 (32%), Gaps = 20/416 (4%)

Query: 11  LLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTG-IA 69
            L   A+ +G+ +  I ++   + S+  +L    +  +        L  I        +A
Sbjct: 28  RLLPIAIGVGVLAGSITLLFRWLLSLGDSLRTGLIEWSWQAPMVGWLLPIVWAITGATLA 87

Query: 70  VGLVIRFSQGHAG----PDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMT 125
           V L  R++   +G       A    +        +P  I+  +L + GG++LG E P + 
Sbjct: 88  VWLTRRYAPEASGSGIPHIEAVLYRLRDLRWRRIIPVKIIGGVLAIGGGLALGREGPSVQ 147

Query: 126 VNIALAVAIGARLLPRVNRME-WTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWD 184
           +  AL   +   L              S   + A F  P+A  +   + L       ++ 
Sbjct: 148 IGGALGGGMAELLRSGPRERLTLIAAGSGAGLAAAFNAPLAGLVFVLEELQRDFRPSVFG 207

Query: 185 RLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCL 244
             F          + T LF        I  Y    ++ +    ++  +    G+V    L
Sbjct: 208 AAFVAA---VVANVITRLFTGQLPVFAIPDYPIQPLSTLPVFIVLGIVCGVTGVVFNKVL 264

Query: 245 PR-LHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFL 303
              L  +        LV  +   +   L     P  +  G    + ++  Q    +   +
Sbjct: 265 LAMLEGVAQLRPRQKLVYTMLTGLCVGLVGWWYPTLIGGGHHFTEDVLRGQ-IDLTLLPI 323

Query: 304 LAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAI------TVSCAIL 357
           L  I+ A  +++ A+G  GG   P + +G  +G  + E    +   +           + 
Sbjct: 324 LLAIRFALTMLSYATGAPGGIFAPLLILGALIGYGVGETTHRIAPFLAPQAEVFGVVGMA 383

Query: 358 GIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL---AGKPMMMVNRPK 410
            +   + R     + + A +  N   L  L +    A+ +      +P+      +
Sbjct: 384 ALFTGIVRAPLTGIVLIAEMTGNYNQLLPLLLACFFAYAVAEVLRDRPIYEALLRR 439


>UniRef50_B6YRP1 Voltage-gated ClC-type chloride channel n=33 Tax=Bacteria
           RepID=B6YRP1_AZOPC
          Length = 608

 Score =  210 bits (535), Expect = 8e-53,   Method: Composition-based stats.
 Identities = 64/434 (14%), Positives = 143/434 (32%), Gaps = 40/434 (9%)

Query: 3   HPRARTMLL---LSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWI 59
           H R + +     + + +   GI ++   +++ KI  ++Q  L   +         +    
Sbjct: 27  HWREKHIKEPHFILILSFITGILTAFAGVLLKKIICLIQYFLKNEI-----YTTYNEYSY 81

Query: 60  IGVLTLTGIAVGLVIRFSQG-----HAGPDPACEPLIGAPVPPSALPGLIVALILGLAGG 114
           +    +  +  GL ++F                     + +    L   ++A  + +  G
Sbjct: 82  LVCPAIGILFSGLFVKFIAKNDIGHGITKILYAISQRKSRLKMHNLWTSLIASSVTIGFG 141

Query: 115 VSLGPEHPIMTVNIALAVAIGARLLPRVNRMEWTI-LASAGTIGALFGTPVAAALIFSQT 173
            S+G E P +    A+   +G         +   I   +AG I  +F  P+A  L   + 
Sbjct: 142 GSVGAEAPSVITGSAIGSNLGRLFKMDQKTLMLLISCGAAGAIAGVFKAPIAGLLFTIEV 201

Query: 174 LNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIA 233
           L           +   L+++   A  + +F               ++ +I    ++    
Sbjct: 202 LMLDLTT---VSVLPLLISSVTAASISYIFTGSEAMFKYNQTVAHDIKNIPYVLLLGVTC 258

Query: 234 IAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVAN 293
               +  V  L  + ++ +++KN        G ++  + V   P    +G D +  ++ N
Sbjct: 259 GLITVYFVRVLIWIESIFNRLKN-YWQRFALGAVILNILVFLFPPLYGEGYDIIDDLINN 317

Query: 294 Q----------------AFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGL 337
           Q                  S   + L+   K+ A       G  GG   P++F+G  +G 
Sbjct: 318 QYDQILNNTFVSGMNISGVSVLFFMLVIFTKVFATGATTGGGGCGGIFAPSLFLGCTIGF 377

Query: 338 MLHEHVPA------VPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVM 391
           +    +        +P        + G++  +      ++F+ A +     L   L IV 
Sbjct: 378 IFSHLLNLLGGNNFLPENNFSLIGMAGMMSAILHAPLTAIFLIAELTGGFGLFLPLMIVS 437

Query: 392 LPAWLLLAGKPMMM 405
             A+  +       
Sbjct: 438 SSAYFTILLFEKYS 451


>UniRef50_B0BZR2 Cl-channel, voltage gated, putative n=7 Tax=Cyanobacteria
           RepID=B0BZR2_ACAM1
          Length = 871

 Score =  210 bits (535), Expect = 8e-53,   Method: Composition-based stats.
 Identities = 67/415 (16%), Positives = 142/415 (34%), Gaps = 25/415 (6%)

Query: 2   LHPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIG 61
           L    ++     + A  IG+ S L  + +      L       L  +L     SPL +  
Sbjct: 10  LRHLTQSSRFAIIEACLIGLISGLAAVALQDGIGWL-----GGLRISLANQFHSPLILPL 64

Query: 62  VLTLTGIAVGLVI-RFSQGHAGP-DPACEPLIGA---PVPPSALPGLIVALILGLAGGVS 116
           +  + G+  GL+I   +    G   P  +  +      +        + + I  L  G+ 
Sbjct: 65  IGVIGGLIAGLLIETIAPDAKGSGIPQVKAALAQFPIALNWQVALVKLFSGITALGTGLP 124

Query: 117 LGPEHPIMTVNIALAVAIGARLLPRVNRME-WTILASAGTIGALFGTPVAAALIFSQTLN 175
           LG + P + +  ALA  +        N  +      +   + A F  P+A  L   + L 
Sbjct: 125 LGRQGPTVQLGAALAAQLSYWFPTAPNHRQQMIAAGAGAGLAAGFAAPIAGVLFIVEELL 184

Query: 176 GSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSL---PIAHYGQMEMTDILSGAIVAAI 232
                     L   ++++  GA+   +    + S+    +       + +I    ++  +
Sbjct: 185 HDLS---GLTLGTAILSSFIGAVVAHVLGGQNLSISFEQVTTATSFSVPEIPFFILLGIL 241

Query: 233 AIAAGMVAVWCLPRLHAMMHQMK--NPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQM 290
           A   G +    L     +  ++K       + + G I G +       S+F+    ++ +
Sbjct: 242 AGGFGAIFNRGLLLSVDLNRRLKFLGLPWRISLAGGICGSIIGQL--PSIFQDNTGLRGL 299

Query: 291 VANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLH----EHVPAV 346
           +              V++    ++A  SG  GG   P++ +G ALG ++     + + A 
Sbjct: 300 LGLGDLGWQLALTAFVVQFGLTLIAYGSGAPGGLFAPSLVMGAALGNLVGLGQAQLLGAG 359

Query: 347 PAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGK 401
                    +      V+R     + +   +  +  L+  L I  + A+L     
Sbjct: 360 LPTTYAFVGMGAFFGAVSRVPVTGIVIIFEITQDFNLVLPLMISSVVAYLTAEQI 414


>UniRef50_B9L7R0 Voltage-gated chloride channel n=2 Tax=Nautiliaceae
           RepID=B9L7R0_NAUPA
          Length = 573

 Score =  210 bits (535), Expect = 9e-53,   Method: Composition-based stats.
 Identities = 71/428 (16%), Positives = 136/428 (31%), Gaps = 30/428 (7%)

Query: 12  LSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTL------------GIAQDSPLWI 59
           L L    IGI  S+   + + +   +     + L G L               + + L +
Sbjct: 14  LILDTFIIGIIGSVCAQIFIVLLHFISKFSLEYLVGYLPQDTLKLLESYQHSGEFNNLML 73

Query: 60  IGVLTLTGIAVG-LVIRFSQGHAGP----DPACEPLIGAPVPPSALPGLIVALILGLAGG 114
           I V+   G+  G LV  F+    G             G  +    +P  I+A  + +  G
Sbjct: 74  IAVIVSGGLISGFLVYTFAPEAEGHGTDTVIRAFHRQGGYIRWIVVPVKILASAITIGTG 133

Query: 115 VSLGPEHPIMTVNIALAVAIGARLLPRVNRMEW-TILASAGTIGALFGTPVAAALIFSQT 173
            S G E P    +  +             R +   ++  A  + A+F  P+  ++   + 
Sbjct: 134 GSAGREGPTALFSAGVGSWYSDLRKVGWKRRQIYVLIGMASGLSAVFKAPLGTSIFAIEV 193

Query: 174 LNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIA 233
           L   +E    + L   L       + TG  F       +      ++   L    +  ++
Sbjct: 194 LYADNEFETRE-LIYLLFGPLIAYMITGFLFGWEPIFYVPEINITDLKTYLEIVFLGIMS 252

Query: 234 IAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVAN 293
               +V       +      +          G  +  +  I  P  L  G   +Q+ +  
Sbjct: 253 GMIALVLPNIFYGIRDFFRSLPVKPHFKPAIGAFVVGIIAIYFPEVLGGGYGFIQESING 312

Query: 294 QAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVS 353
                     L + K+ A      SG  GG   P++F+G  LG  L   + A P A  V 
Sbjct: 313 NMI-GMFVIFLMIAKIFAFSFTVGSGGSGGVFAPSLFIGAMLGAFLGSSLHA-PVAAFVV 370

Query: 354 CAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLL---------LAGKPMM 404
            A+  +     R    ++ M   +    +LL    + +L A+++              + 
Sbjct: 371 IAMAAVFGAAARTPLATIVMVVEMTGGYSLLAPTTLGVLSAYIVHNILVRVIKPKYISLY 430

Query: 405 MVNRPKQQ 412
                 ++
Sbjct: 431 EAQLLNKE 438


>UniRef50_C5PI54 Voltage gated chloride channel, putative n=7 Tax=Leotiomyceta
           RepID=C5PI54_COCP7
          Length = 892

 Score =  209 bits (533), Expect = 1e-52,   Method: Composition-based stats.
 Identities = 54/457 (11%), Positives = 121/457 (26%), Gaps = 71/457 (15%)

Query: 13  SLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLW-------------- 58
            L    +G A  L    +  +   L ++          + +    W              
Sbjct: 121 WLVVTIVGAAIGLNAGFLNIVTEWLADVKLGYCTTAFYLNEAFCCWEAENGKCPEWKRWS 180

Query: 59  ----------IIGVLTLTGIAVGLVIRFSQGHAGP------DPACEPLIGAPVPPSALPG 102
                      +  +        LV   +   AG             ++   +    L  
Sbjct: 181 TLPPINYVVYFVFAVLFASSGAVLVDAIAPYAAGSGISEIKVIIAGFIMKGFLGVRTLLI 240

Query: 103 LIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARL----LPRVNRMEWTILASAGTIGA 158
             + L L +A G+S+G E P + + +     I               E     SA  +  
Sbjct: 241 KSIGLPLAIAAGLSVGKEGPSVHIAVCTGNVISRWFSKYKRHAAKTREILTATSAAGVAV 300

Query: 159 LFGTPVAAALIFSQTLNGSSEV-PLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQ 217
            FG+P+   L   + +     +  LW   F  L+A    A              + +   
Sbjct: 301 AFGSPIGGVLFSLEEMASHFPLKTLWRSYFCALVATGVLAAMNPFRTGQLVMFQVKYERT 360

Query: 218 MEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQ--MKNPVLVLGIGGFILGI----- 270
               +++   I+       G   +    R  A   +   ++P+L   +   +  +     
Sbjct: 361 WHFFELIFFVILGVFGGLYGAFVMKWNLRAQAFRKKHLSRHPILEATVLAGLTALVCYPN 420

Query: 271 ----LGVIGGPVSLFK---GLDEMQQMVANQAFS--TSDYFLLAVIKLAALVVAAASGFR 321
               + +      LF+   G  +   +             F+  V+++  ++++      
Sbjct: 421 MFMRITMTEMMEILFRECEGKHDYNGICQAAHRWSMVFSLFMATVLRVLFVIISYGCKVP 480

Query: 322 GGRIFPAVFVGVALGLMLHEH--------------------VPAVPAAITVSCAILGIVL 361
            G   P++ +G + G M+                       VP +             + 
Sbjct: 481 AGIFVPSMAIGASFGRMVGILVQALQESFPHSKFFAACEPDVPCITPGTYAFLGAGAALS 540

Query: 362 VVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL 398
            +         +   +    T +    IV+     + 
Sbjct: 541 GIMHLTISVTVIMFELTGALTYILPTMIVVGVTKAVS 577


>UniRef50_B8HWS8 Chloride channel core n=6 Tax=Bacteria RepID=B8HWS8_CYAP4
          Length = 640

 Score =  209 bits (533), Expect = 1e-52,   Method: Composition-based stats.
 Identities = 68/394 (17%), Positives = 144/394 (36%), Gaps = 22/394 (5%)

Query: 23  SSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRFSQGHAG 82
           + L +++   +   + +L  +++ G   IA      +  V TL G+ VGL+  + +    
Sbjct: 50  TGLSVVLFHYLIEAIHSLTLEQMMG--AIAPWGAWTLALVPTLGGVVVGLMRWWLRDFGP 107

Query: 83  PDPA-CEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARLLPR 141
              A        P+        + A  + L  G SLGPE P + +   + + +   L   
Sbjct: 108 GISAMVTTQASEPIALVRPAIKMTAASVSLGTGASLGPEGPSVEIGANIGMVLAQMLRVS 167

Query: 142 VNRMEWTILASAGTIGAL-FGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTT 200
             R    + A A    A  F  P+A   +  + +  ++       + A L++A   AL T
Sbjct: 168 QERRRLLLGAGAAAGLAAGFNAPIAGVFLSLELVLSTTFAT--TTVGAVLLSAVVAALIT 225

Query: 201 GLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMM--------H 252
            +      +  +  Y      ++     +  +A    ++ V  +     +          
Sbjct: 226 QIGLGSQPAFALPVYEVRSPWELPLYVGLGILASGISLIFVEAIKFCQQLFEGQLPGLGW 285

Query: 253 QMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAAL 312
             K P+ +  + G     L  +  P  L  G + ++ ++ N  FS     LL ++KL   
Sbjct: 286 VGKIPLSLQPVIGGGCVGLVALAVPQVLGIGYETVEAVLRNVVFSLPLLLLLLLVKLMMT 345

Query: 313 VVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAV--------PAAITVSCAILGIVLVVT 364
            ++  SG  GG   P++F+G  LG    + +  +                 +  ++   T
Sbjct: 346 AISLGSGLVGGIFAPSMFLGATLGAAYGQVMALLLPPGLAIAAPPAYAMVGMAAVLAGST 405

Query: 365 RDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL 398
           R    ++ +   +  +  ++  L   +  + LL+
Sbjct: 406 RSPLTAILLLFELTRDYRIILPLMAAVGISVLLV 439


>UniRef50_B3PL72 Voltage-gated chloride channel n=1 Tax=Cellvibrio japonicus Ueda107
           RepID=B3PL72_CELJU
          Length = 580

 Score =  209 bits (533), Expect = 1e-52,   Method: Composition-based stats.
 Identities = 55/384 (14%), Positives = 112/384 (29%), Gaps = 16/384 (4%)

Query: 26  ILIVVMKIASV-LQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRFSQGHAG-- 82
           ++++   +  + L   L         ++    + +     L    V   I       G  
Sbjct: 52  VIVLFRWLIEIPLGYWLPDHFENFEALSGQMHIILPLAGALLLGLVLQFIDKRHHATGVA 111

Query: 83  PDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARL-LPR 141
                       +P              L  G S+G E P + +       +G  L LP 
Sbjct: 112 HVIDRLQNHQGRMPWGNFSVQFWGGATCLLSGQSVGREGPAVHLGAGAGSLLGQWLKLPG 171

Query: 142 VNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTG 201
            +         A  I A F TP+A  +   + +     +         ++AA AG   + 
Sbjct: 172 NSLRPLAGCGVAAAIAACFNTPMAGVIFAMEVVMMEYTIA---GFIPVILAAVAGTTISH 228

Query: 202 LFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVL 261
           L F    +  +       + ++    +            +    +     H + +PVL+ 
Sbjct: 229 LAFGNVINFELLQSDHAGLLELPLVILAGLFIALLAAAYIRL--QAFWCRHSLNHPVLLR 286

Query: 262 GIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFR 321
                +L  L     P  +  G D + Q +            + + KL     A   G  
Sbjct: 287 FAIAGLLTGLVAYAFPHIMGVGYDTINQALQGN-LGFWLLLGILIAKLFVTTAALGLGMP 345

Query: 322 GGRIFPAVFVGVALGLMLHEHVPAV------PAAITVSCAILGIVLVVTRDGWLSLFMAA 375
           GG I P +F+G   G  +      +           V   +  ++         ++    
Sbjct: 346 GGVIGPLLFIGACAGGAIGIIANNLMPGSASHIGFYVVLGMGAMMGATLNAPMAAMMAII 405

Query: 376 VVVPNTTLLPLLCIVMLPAWLLLA 399
            +  N  ++    ++++ A L   
Sbjct: 406 ELTYNPAIIFPSMLMVVVACLSTR 429


>UniRef50_P74477 Chloride channel protein n=12 Tax=Chroococcales RepID=P74477_SYNY3
          Length = 899

 Score =  208 bits (530), Expect = 3e-52,   Method: Composition-based stats.
 Identities = 67/396 (16%), Positives = 139/396 (35%), Gaps = 15/396 (3%)

Query: 13  SLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGL 72
              A  IG  S+L  +V+    + L +           I     +     L   G+A  L
Sbjct: 30  IAEACVIGFVSALAALVIKNGVNWLGSSRLSLADTYGAI----WVLPCFGLVFGGLAGAL 85

Query: 73  VIRFS-QGHAGPDPACEPLIGA---PVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNI 128
           + +FS     G  P  +  +     P+        ++  +L L GG++LG   P + +  
Sbjct: 86  IEQFSRPAGGGGIPQVKAALARYPIPLDWRVAVVKLLGTVLVLGGGMTLGRRAPTVHIGA 145

Query: 129 ALAVAIGARLL-PRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSS-EVPLWDRL 186
           ALA  +         +R +     +A  + A F TP+A  L   + L      + L   +
Sbjct: 146 ALAAQLSRWFPTSPEHRRQMIAAGAAAGLAAGFTTPIAGVLFVVEELMRDVSSLTLETAI 205

Query: 187 FAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPR 246
            A  + A    +      +   SL  +   +    +I    ++  +A   G++    +  
Sbjct: 206 VASFVGAVTSLVFQSSDLNLAHSLSNSPTVRFTTGEIPFYLLLGILAGILGVLLNRSILS 265

Query: 247 LHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAV 306
           L     +    +++      ++  + +   P   F+    +++ V +   S     L  V
Sbjct: 266 LQNWQRKQNLSLVIRIGVVGLISGVAIALLPS-FFRDNAGLREFVTSGELSWHQVVLTLV 324

Query: 307 IKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEH----VPAVPAAITVSCAILGIVLV 362
                 ++A ++   GG   PA+ +G ALG ++ E        V         +      
Sbjct: 325 AHFILTILAYSTDAPGGLFAPALVMGSALGYLVGEFGSYWQDQVTQTTFALAGMGAFFTS 384

Query: 363 VTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL 398
           V R    ++ +   +  N  ++  L +    ++L+ 
Sbjct: 385 VVRVPVTAIIIVFELTGNFNVVLPLMVACATSYLVA 420


>UniRef50_A7HVW3 Chloride channel core n=1 Tax=Parvibaculum lavamentivorans DS-1
           RepID=A7HVW3_PARL1
          Length = 629

 Score =  208 bits (530), Expect = 3e-52,   Method: Composition-based stats.
 Identities = 71/419 (16%), Positives = 141/419 (33%), Gaps = 32/419 (7%)

Query: 5   RARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQR------LPGTLGIAQDSPLW 58
           R   M++LSL A+A+G+A+ +  ++   +   L NL +          G  G        
Sbjct: 46  RQVNMVVLSLLALAVGLATGVGAVIFRSMLVGLHNLFFFGQLSLTPTSGATGPLSPLGAL 105

Query: 59  IIGVLTLTGIAVGLVIRFS-----QGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAG 113
           II V  L GIAV  + R        G               + P       +A  L +  
Sbjct: 106 IILVPVLGGIAVVWITRRFAPEAKGGGITDVMDAVYHREGKIRPRVAVVKTIASALSIGS 165

Query: 114 GVSLGPEHPIMTVNIALAVAIGARLL-PRVNRMEWTILASAGTIGALFGTPVAAALIFSQ 172
           G ++G E PI+ +  A+  AI      P   R+      ++  I A F TP+ A L   +
Sbjct: 166 GATVGREGPIVQIGSAIGSAIAQFSRLPSWQRITLLAAGASAGISATFNTPLGAVLFALE 225

Query: 173 TLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQM-----EMTDILSGA 227
            +               ++A  +      + F  + +  +            + ++ +  
Sbjct: 226 LILPEISA---RTFLPVVIATGSATYVGRVVFGSYPAFVLPQMSFATSEMDHIFNLGAFV 282

Query: 228 IVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGG------PVSLF 281
           ++  ++       +  L     +M +      +    GF    + +            + 
Sbjct: 283 VLGLMSGLVAWGFLRTLLFAGDVMPRRFPNEYMRAAAGFTGIGIALFLFAHFTGHYYIIG 342

Query: 282 KGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHE 341
            G D +  ++     S      L V ++ A  ++  SG  GG   P +F+G +LG     
Sbjct: 343 GGYDAIAAILEGHVTSFLLLAALCVAQVFATSLSIGSGASGGVFAPMLFIGASLGGAFGA 402

Query: 342 HV------PAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPA 394
            +        +  A      +  +V   T     ++ M   +  +  ++  L I +  +
Sbjct: 403 LLHIFDADHGIGVADYAIIGMAAVVGGGTGAAMTAITMNFEMTRDYNIIVPLIIAVAVS 461



 Score = 41.3 bits (96), Expect = 0.060,   Method: Composition-based stats.
 Identities = 35/250 (14%), Positives = 74/250 (29%), Gaps = 36/250 (14%)

Query: 166 AALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTG---LFFHPHFSLPIAHYGQMEMTD 222
             +  ++     + V L     A  +A   GA+      +  H  F              
Sbjct: 37  GGVREAEDTRQVNMVVLSLLALAVGLATGVGAVIFRSMLVGLHNLFFFGQLSLTPTSGAT 96

Query: 223 ILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFK 282
                + A I                         +LV  +GG  +  +     P +   
Sbjct: 97  GPLSPLGALI-------------------------ILVPVLGGIAVVWITRRFAPEAKGG 131

Query: 283 GLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEH 342
           G+ ++   V ++         +AV+K  A  ++  SG   GR  P V +G A+G  + + 
Sbjct: 132 GITDVMDAVYHREGKIRP--RVAVVKTIASALSIGSGATVGREGPIVQIGSAIGSAIAQF 189

Query: 343 --VPAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVV----PNTTLLPLLCIVMLPAWL 396
             +P+      ++      +         ++  A  ++       T LP++       ++
Sbjct: 190 SRLPSWQRITLLAAGASAGISATFNTPLGAVLFALELILPEISARTFLPVVIATGSATYV 249

Query: 397 LLAGKPMMMV 406
                     
Sbjct: 250 GRVVFGSYPA 259


>UniRef50_A6T4V9 H(+)/Cl(-) exchange transporter clcA n=13 Tax=Gammaproteobacteria
           RepID=CLCA_KLEP7
          Length = 472

 Score =  208 bits (530), Expect = 3e-52,   Method: Composition-based stats.
 Identities = 70/414 (16%), Positives = 137/414 (33%), Gaps = 19/414 (4%)

Query: 2   LHPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTL-GIAQDSPLWII 60
           L  R +T L +   A  +G  + L+ +   K  + +QN     L           PL  I
Sbjct: 25  LIQRDKTPLAVLFMAAVVGTLAGLVGVAFEKSVNWVQNQRIGALAQVADHWYLVWPLAFI 84

Query: 61  GVLTLTGIAVGLVIRFSQGHAGP-DPACEPLIGAPVP---PSALPGLIVALILGLAGGVS 116
               L  +   LV RF+    G   P  E  +    P      LP   V  +  L  G+ 
Sbjct: 85  LSALLAMVGYFLVRRFAPEAGGSGIPEIEGALEELRPVRWWRVLPVKFVGGMGTLGAGMV 144

Query: 117 LGPEHPIMTVNIALAVAIGA--RLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTL 174
           LG E P++ +   +   +    R+     R       +A  + A F  P+A  L   + +
Sbjct: 145 LGREGPMVQLGGNIGRMVLDVFRMRSPEARHTLLATGAASGLSAAFNAPLAGILFIIEEM 204

Query: 175 NGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAI 234
                  L   + A        ++   +F      + +       +  +    ++  +  
Sbjct: 205 RPQFRYNL-ISIKAVFTGVIMSSIVFRIFNGEAAIIEVGKLSNAPVNTLWLYLVLGMLFG 263

Query: 235 AAGMVAVWCLPRLHAMMHQMK----NPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQM 290
             G +  + + R   +  ++        +++G     L  L  +  P ++  G + +   
Sbjct: 264 CFGPLFNFLVLRTQDLFQRIHGGNIKKWVLIGGLIGGLCGLLGLMQPSAVGGGFNLIPIA 323

Query: 291 VANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAI 350
            A   FS      + + ++   ++  +SG  GG   P + +G  LG         +  A 
Sbjct: 324 AAGN-FSVGLLLFIFIARVVTTLICFSSGAPGGIFAPMLALGTLLGTAFGMAAIPLFPAY 382

Query: 351 ------TVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL 398
                      +  ++    R     + +   +  N  L+  + I  L A LL 
Sbjct: 383 HLDAGTFAIAGMGALLAASVRAPLTGIVLVLEMTDNYQLILPMIITCLGATLLA 436


>UniRef50_C6W519 Chloride channel core n=1 Tax=Dyadobacter fermentans DSM 18053
           RepID=C6W519_DYAFD
          Length = 617

 Score =  208 bits (529), Expect = 4e-52,   Method: Composition-based stats.
 Identities = 62/408 (15%), Positives = 131/408 (32%), Gaps = 28/408 (6%)

Query: 12  LSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVG 71
           L L  + +GI   L  +V+  +   + +++  R+     +     L+    + LT + V 
Sbjct: 49  LILSGILVGITCGLAGVVLKSLVHYIHHVITYRVHFERQV-FFYILFPFLGIVLTTVVVQ 107

Query: 72  LVIR-FSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIAL 130
              +   +              + V    +   IV   + +  G S G E PI     A+
Sbjct: 108 FFFKGQDRKGIAAVLYEIAQNSSIVSSVKMYSQIVQSAITVGLGGSAGLESPIAVTGAAI 167

Query: 131 AVAIGARLLPRVNRM-EWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAP 189
                                 +   I + F  P+A  +   + L       ++   F  
Sbjct: 168 GSNFAQTYKLDYRERTLLLAAGATAGIASAFNAPIAGMMFAFEILLTGV---VFFDFFPL 224

Query: 190 LMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHA 249
           ++AA  G+LT+ +          +     +  +I    ++  +    G   V     +  
Sbjct: 225 VVAAVCGSLTSKVLLKESVLFQFSSRAPFDYHNIPFYLLLGILCGLYGRYYVLIGKYVDQ 284

Query: 250 MMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQA-------------- 295
             H +K   +     G  +  +  +  P    +G D ++ +   Q               
Sbjct: 285 WFHNLKMGRIQKAAIGGAVLSVLCVLYPPLFGEGYDTIKAITNGQIQEVIANSFFRFIGY 344

Query: 296 ---FSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEH-----VPAVP 347
                     ++ ++K  +  +   SG  GG   P++F G  +G           +  VP
Sbjct: 345 HEWVVIVFVAVICLLKAFSASITIFSGGNGGNFAPSLFAGGLVGYAFALVCTQLGIEHVP 404

Query: 348 AAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAW 395
            +  V   + G++  V      ++F+ A       L   L IV + ++
Sbjct: 405 ESNLVIVGMAGVMSGVLYAPLTAIFLIAESTYGYDLFIPLMIVSVISF 452



 Score = 41.7 bits (97), Expect = 0.051,   Method: Composition-based stats.
 Identities = 13/114 (11%), Positives = 31/114 (27%), Gaps = 10/114 (8%)

Query: 101 PGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIG----ARLLPRVNRMEWTILASAGTI 156
                +  + +  G + G   P +     +  A         +  V      I+  AG +
Sbjct: 358 LLKAFSASITIFSGGNGGNFAPSLFAGGLVGYAFALVCTQLGIEHVPESNLVIVGMAGVM 417

Query: 157 GALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSL 210
             +   P+ A  + +++  G             ++ +         F      L
Sbjct: 418 SGVLYAPLTAIFLIAESTYGYD------LFIPLMIVSVISFSMAKWFSSVSPDL 465


>UniRef50_UPI000174564F putative voltage-gated ClC-type chloride channel ClcB n=1
           Tax=Verrucomicrobium spinosum DSM 4136
           RepID=UPI000174564F
          Length = 522

 Score =  206 bits (526), Expect = 8e-52,   Method: Composition-based stats.
 Identities = 57/336 (16%), Positives = 111/336 (33%), Gaps = 11/336 (3%)

Query: 66  TGIAVGLVIRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMT 125
             +         Q           L    +P  A     ++ ++ +A G S+G E P++ 
Sbjct: 21  GFVLQWGTRWKRQESTTDYMEAIALGDGNIPIRASLMKSLSALVSIASGASIGREGPLVQ 80

Query: 126 VNIALAVAIGARLLPR-VNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWD 184
           +    A  +G         R       +A  I + +  P+  A+  ++ + G+     ++
Sbjct: 81  LAAMAASTLGRLWKSGMAQRRLLVACGAAAGIASAYNAPLTGAMFVAEVVLGTL---AFE 137

Query: 185 RLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCL 244
            L   L ++     T    F       +        T + +   V   A A G + +  L
Sbjct: 138 TLGPLLFSSVVATATVRHVFGEAALYQVEVLNAGGATALPAHLGVGIAAGAVGPLFLVVL 197

Query: 245 PRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLL 304
                +    + PV +    G  +  L     P     G   +  M+           + 
Sbjct: 198 RWGTRLFVIAEWPVPLRLAVGGFMVGLLAAWHPQVCGNGSHLLNDMLHAPPE-LGLLVVY 256

Query: 305 AVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAIT------VSCAILG 358
           A++KL A V   +SG  GG   P +F+G ALG + H  + A    +           +  
Sbjct: 257 ALLKLTATVTTFSSGAVGGVFTPTLFLGAALGQICHVAIHAAFPGLAVPAGALAIVGMGA 316

Query: 359 IVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPA 394
            +   T     ++ M   +  +  L+  L +  + A
Sbjct: 317 FLAATTHAPVTAILMVFEMTLDYPLVLPLMLACVVA 352



 Score = 44.8 bits (105), Expect = 0.006,   Method: Composition-based stats.
 Identities = 26/192 (13%), Positives = 52/192 (27%), Gaps = 27/192 (14%)

Query: 19  IGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRFSQ 78
           +GIA+  +  + + +      L              +   +   L + G  VGL+  +  
Sbjct: 182 VGIAAGAVGPLFLVVLRWGTRLF-----------VIAEWPVPLRLAVGGFMVGLLAAWHP 230

Query: 79  GHAGPDPACEPLIGAPVP-----PSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVA 133
              G        +    P            + A +   + G   G   P + +  AL   
Sbjct: 231 QVCGNGSHLLNDMLHAPPELGLLVVYALLKLTATVTTFSSGAVGGVFTPTLFLGAALGQI 290

Query: 134 I-----GARLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFA 188
                  A     V      I+     + A    PV A L+  +          +  +  
Sbjct: 291 CHVAIHAAFPGLAVPAGALAIVGMGAFLAATTHAPVTAILMVFEMTL------DYPLVLP 344

Query: 189 PLMAAAAGALTT 200
            ++A       +
Sbjct: 345 LMLACVVAHGIS 356


>UniRef50_A8ZW16 Chloride channel core n=1 Tax=Desulfococcus oleovorans Hxd3
           RepID=A8ZW16_DESOH
          Length = 603

 Score =  206 bits (525), Expect = 1e-51,   Method: Composition-based stats.
 Identities = 60/407 (14%), Positives = 136/407 (33%), Gaps = 18/407 (4%)

Query: 8   TMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTG 67
             L+  L AV +G  + +  I    +   ++ L        L      P  I+ V     
Sbjct: 31  RYLIQILFAVLVGSLAGIGAIFFHYVVEEMRLLFSPDRFDLLWPGILHP--IMLVPVAGA 88

Query: 68  IAVGLVIRFSQGHAG-----PDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHP 122
           + + +        AG            +    +P       + A I+ +  G  LGPE P
Sbjct: 89  LVLAVATVRFPKTAGERGVESVIKALIIKNGVIPLKTTLFHMFAAIMTIGTGAPLGPEGP 148

Query: 123 IMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVP 181
              +   +  A+     L R N   +T   +   I A+F  P+A      + +  +    
Sbjct: 149 AAKIGSGMGSALSQWFGLNRENIKIYTAAGAGAAISAVFNAPIAGVFFAIEVVLLNDLKN 208

Query: 182 LWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAV 241
             + L   ++A+    + +           I HY  +    +    ++A    A  +   
Sbjct: 209 --EALSFLIIASIVADILSRAVLGNDVIFTIPHYAPIHFAHLPWFLLLAVCCGAMSLFYF 266

Query: 242 WCLPRLHAMMHQMK--NPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTS 299
                +  +  ++       V  +   ++  L ++        G   M  ++ N AF+  
Sbjct: 267 GTSKTVKHLFDRLPGNQNPFVRLLPVAVVFGLVLLHFNELFGIGYTTMNAVL-NNAFAPV 325

Query: 300 DYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVP-----AVPAAITVSC 354
               L + ++  L +   +G  GG   PA+ +GV  G +    V      ++   +    
Sbjct: 326 VVLWLMLFRIVFLALFLRAGAFGGTFAPALGIGVMFGFLFATTVNTLLGTSLDPVVFGLV 385

Query: 355 AILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGK 401
            + G++  +      S+ +   +  +  ++  L    + +++++   
Sbjct: 386 GMGGVLAGINSIPLTSILLVFELTRDFRIVLPLMAASIISYIVVIYV 432


>UniRef50_C7M702 Chloride channel core n=15 Tax=Bacteroidetes RepID=C7M702_CAPOD
          Length = 598

 Score =  206 bits (525), Expect = 1e-51,   Method: Composition-based stats.
 Identities = 66/414 (15%), Positives = 136/414 (32%), Gaps = 39/414 (9%)

Query: 22  ASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRFSQGH- 80
           A+ L  + +     ++Q LL  +L  T+  +         +  L    V LV ++   H 
Sbjct: 37  ATGLAALAMRSFTHLIQWLLDDKLAQTITYSF-----YFILPMLGFAIVYLVKKYVIRHD 91

Query: 81  ----AGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGA 136
                             +      G I+   + +  G S+G E P++     ++  I  
Sbjct: 92  VNHGIPSILYAVAHQKGIMKRFQAYGSILTAPITVGFGGSVGLEGPMVVTGAGISSNICR 151

Query: 137 RLLPRVNRME-WTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAA 195
                 +        A A  + A+F  P+AA L   +       +     L    +A+  
Sbjct: 152 FFHINQSNRMLLLACACAAALAAIFKVPIAAILFAIEVFGLDLTL---SSLIPLFIASLC 208

Query: 196 GALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMK 255
           G  T+  FF     +PI       +  I    ++  +         +   +++A   ++ 
Sbjct: 209 GVFTSYFFFGSEVLIPITITRAFSLQGIPFYILLGVVGGLMSAYFTYVYEKINATFKKLT 268

Query: 256 NPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQM-----------------VANQAFST 298
           +P L + +GG +LG+L +   P    +G + +  +                 ++N     
Sbjct: 269 SPWLKIVVGGALLGLL-IYIMPPLYGEGHEIINHLKEGHPELSLSSNIFGWDLSNAWVII 327

Query: 299 SDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPA-------AIT 351
                L   K+ A  +   +G  GG   P +F+G  +G  L   +   P           
Sbjct: 328 LLLAALTFAKVIATSLTFGAGGVGGIFSPMLFMGGVMGNCLARIINEFPILGYKAELPNF 387

Query: 352 VSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMM 405
               +  ++  V      ++F+ A V    +LL    +    ++ +        
Sbjct: 388 TLVGMTALMTGVLHAPLTAVFLIAEVTGGYSLLVPAMLTAAVSFSVAKYFNKYS 441


>UniRef50_B9XGZ2 Chloride channel core n=3 Tax=Verrucomicrobia RepID=B9XGZ2_9BACT
          Length = 603

 Score =  206 bits (524), Expect = 1e-51,   Method: Composition-based stats.
 Identities = 70/416 (16%), Positives = 146/416 (35%), Gaps = 16/416 (3%)

Query: 8   TMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQR---LPGTLGIAQDSPLWIIGVLT 64
            +LLLS  A  IG  S+ +   ++ + S++ N+ +     +            W+I +  
Sbjct: 22  RVLLLSGMAAIIGAISAGVAYGLLWLISLITNISFFHRFKVEDVTPQDAHIGAWVIIIPV 81

Query: 65  LTGIAVGLVIRFS-----QGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGP 119
           +  + +GL+ R+                  +  + + P       ++  + +  G   G 
Sbjct: 82  IGALIIGLMARYGSPKIRGHGIPEALEAILIGRSKLEPKVAILKPISSAISIGTGGPFGA 141

Query: 120 EHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSS 178
           E PI+    A          L    R    +  +AG + A+F TP+AA L+  + L    
Sbjct: 142 EGPIIMTGGACGSLFAQYFHLTAAERKTLLVAGAAGGMAAIFSTPIAAILLAVELLLFEW 201

Query: 179 EVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGM 238
           +      L    ++A   +             P+  +G M   ++L   +V   A  A  
Sbjct: 202 KP---RSLIPVAVSAIMASAMRVPLLGAGPIFPVLPHGAMTGAELLVAGVVGIAAGLASG 258

Query: 239 VAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFST 298
                +  L     ++    +     G +   +G    P  L  G   +  ++  +    
Sbjct: 259 AVTTLVYALEDAFKKLPIHWMWWPAIGAVFVGIGGYIDPRVLGVGYKLIHGLLRGE-LVG 317

Query: 299 SDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILG 358
           +    L + K     +A  SG  GG + P + +G ALG +L   +      +    A+  
Sbjct: 318 AAVLGLLIGKAIVWSIALGSGTSGGVLAPLLIMGGALGALLSRWIHIGDTGLWAMVAMGA 377

Query: 359 IVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPA---WLLLAGKPMMMVNRPKQ 411
           ++    R  +     A  +  +   LP + I  + +    +LL  + ++     ++
Sbjct: 378 MMGGTMRAPFTGTIFALELTHDLNALPAVMIGCIASLGVTVLLLRRSILTEKIARR 433


>UniRef50_A4WD06 Cl-channel, voltage-gated family protein n=5 Tax=Bacteria
           RepID=A4WD06_ENT38
          Length = 411

 Score =  206 bits (524), Expect = 1e-51,   Method: Composition-based stats.
 Identities = 329/411 (80%), Positives = 366/411 (89%)

Query: 1   MLHPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWII 60
           MLHPRA+TMLLL+ PA+ IGIASSL+LIVVMK+ASVLQ  LW  LPG LGI   SP WII
Sbjct: 1   MLHPRAKTMLLLATPALIIGIASSLVLIVVMKVASVLQAFLWTALPGKLGIDFASPTWII 60

Query: 61  GVLTLTGIAVGLVIRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPE 120
            +LTLTGI VGLVIRFS GHAGPDPA EPLI APV P+ALPGL++ALI+GLAGGVSLGPE
Sbjct: 61  LMLTLTGITVGLVIRFSPGHAGPDPALEPLISAPVNPAALPGLLLALIIGLAGGVSLGPE 120

Query: 121 HPIMTVNIALAVAIGARLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEV 180
           HPIM VNIALAV +G+R+ PRV  ++WTILASAGTIGALFGTPVAAALIFSQTL+G ++V
Sbjct: 121 HPIMAVNIALAVYLGSRIFPRVGALDWTILASAGTIGALFGTPVAAALIFSQTLSGDNDV 180

Query: 181 PLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVA 240
           PLWDRLFAPLMAAAAGALTT LF+HPHFSLPI HYGQM++ DI SGAIVAAIAIA GMVA
Sbjct: 181 PLWDRLFAPLMAAAAGALTTSLFYHPHFSLPIPHYGQMQLADIFSGAIVAAIAIALGMVA 240

Query: 241 VWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSD 300
           VWCLPRLH +MH++K+ VL+LG GGF+LGILG IGGPV+LFKGLDEMQQM  +Q FS SD
Sbjct: 241 VWCLPRLHRLMHKLKHSVLILGAGGFLLGILGAIGGPVTLFKGLDEMQQMAFSQVFSVSD 300

Query: 301 YFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIV 360
           YFL AVIKLAA+VVAAA GFRGGRIFPAVF+GVALGLMLHEHV AVPAAIT+SC+ILG+V
Sbjct: 301 YFLFAVIKLAAVVVAAACGFRGGRIFPAVFIGVALGLMLHEHVDAVPAAITISCSILGLV 360

Query: 361 LVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNRPKQ 411
           LVVTRD WLSLFMAAVVVP+T LLPLLCIVMLPAWLLLAGKPM+M  R  +
Sbjct: 361 LVVTRDAWLSLFMAAVVVPDTNLLPLLCIVMLPAWLLLAGKPMLMAWRQNK 411


>UniRef50_B0MW79 Putative uncharacterized protein n=1 Tax=Alistipes putredinis DSM
           17216 RepID=B0MW79_9BACT
          Length = 603

 Score =  205 bits (523), Expect = 2e-51,   Method: Composition-based stats.
 Identities = 56/439 (12%), Positives = 129/439 (29%), Gaps = 34/439 (7%)

Query: 2   LHPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIG 61
           L  R  +  +++L A+ +G+ + L   +   +   ++  L    P           + + 
Sbjct: 24  LTKRFTSTQIMALLAIIVGVLAGLGTCLFELLLYGIKAGLTHWFPVEQS-HFLFLFYPVI 82

Query: 62  VLTLTGIAVGLVIRFSQGHAGP-DPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPE 120
            + L  + V  V++ +                + +        +V     +  G S+GPE
Sbjct: 83  GIILASLFVKYVVKDNISEGVTRVLYAMSRKNSYIASHNCWTSVVGGATTIGFGGSVGPE 142

Query: 121 HPIMTVNIALAVAIGARLLPRVNRME-WTILASAGTIGALFGTPVAAALIFSQTLNGSSE 179
            PI+    A+   I                  +   + A+F  P+   +   + L     
Sbjct: 143 APIVLTGAAIGSNISRLAHLNYKNTTLLLCCGAGAALAAIFKAPITGVVFVLEILMLDLT 202

Query: 180 VPLWDRLFAPLMAAAAGALTTGLF--FHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAG 237
                 +   L+++   A        F P  ++ +       +  I    ++        
Sbjct: 203 ---SRTVVPLLISSITAAAVALTIRGFDPIIAISLTPDDAFRLNQIPLFVLLGIFCGLMS 259

Query: 238 MVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQA-- 295
                   R+ A   ++ +P     + G  +  + +   P    +G +    ++      
Sbjct: 260 YYFTTVNARVGAFFKKIDSPY-KKWLIGGAVLGILIYIFPPLYGEGYEGFMSLMHGNTTE 318

Query: 296 ---------------FSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLH 340
                                      K+ A+    A+G  GG   P++FVG  +G +  
Sbjct: 319 LFNNSLFYRFSQIDWVVILFIVGTMFFKVIAMASTNAAGGVGGTFAPSLFVGAFMGAITA 378

Query: 341 EHVPAVPA-----AITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAW 395
                +              + G++  V +    S+F+ A +     L   L I    A+
Sbjct: 379 LVCNTLFGWNLSLVSFTLVGMAGVMSGVMKAPLTSIFLIAELSSGYGLFIPLMITACIAF 438

Query: 396 LLLAGK---PMMMVNRPKQ 411
            +        +      + 
Sbjct: 439 AIDYYLDPDSIYTKQLRQN 457


>UniRef50_C5VMQ7 Putative chloride channel n=1 Tax=Prevotella melaninogenica ATCC
           25845 RepID=C5VMQ7_9BACT
          Length = 598

 Score =  205 bits (523), Expect = 2e-51,   Method: Composition-based stats.
 Identities = 60/415 (14%), Positives = 132/415 (31%), Gaps = 30/415 (7%)

Query: 8   TMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTG 67
              L+ + A AIG+ +SL   ++  I  +++ L+         I     ++ I  + LT 
Sbjct: 23  NRELVLVLAFAIGLLASLAAYILHFIIKLIEELVTSGF-DVATINWLYLIYPIVGIWLTS 81

Query: 68  IAVGLVIRFSQGHAGP-DPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTV 126
           + V  V+R +  H             + +        IVA  + +  G S+G E PI+  
Sbjct: 82  LFVKYVVRDNISHGITRVLYAISTKQSRLKAHNTWSSIVASAITIGFGGSVGAEAPIVLT 141

Query: 127 NIALAVAIGARLLPRVNRMEWTI-LASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDR 185
             A+   +G         +   +   +   +  +F  P+A  +   + L     +     
Sbjct: 142 GSAIGSNLGRIFNLDNRTLMLLVGCGATAAVSGIFKAPIAGLVFTLEVLMVDLTMA---S 198

Query: 186 LFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLP 245
           L   L+A+      +  F                +  +    ++        +  +  + 
Sbjct: 199 LLPILIASVTATCFSYFFTGGSSMFHFQMDNIWGLDRVPPTILLGIACGFVSLYFMRLMS 258

Query: 246 RLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVAN------------ 293
                  ++ +   +  + G ++    +   P    +G D ++  +              
Sbjct: 259 WCENGYGKLSSKPYLKLLVGGLVLSPLIFLFPSLYGEGYDSLRLFIEGKTEADWMQIMSG 318

Query: 294 ------QAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPA-- 345
                   F      L+ + K+ A      +G  GG   P++F+G   G           
Sbjct: 319 SMFAEKSNFLLLYVGLVVMTKVFATSATNGAGGCGGTFAPSLFIGGFGGFFFARFWNMEQ 378

Query: 346 ----VPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWL 396
               +P        +  ++  V       +F+ A +     L   L IV + ++L
Sbjct: 379 LGVYIPEKNFTLYGMAAVMSAVMHAPLTGIFLIAELTGGYQLFIPLIIVTISSYL 433


>UniRef50_A7FM08 H(+)/Cl(-) exchange transporter clcA n=12 Tax=Enterobacteriaceae
           RepID=CLCA_YERP3
          Length = 478

 Score =  205 bits (523), Expect = 2e-51,   Method: Composition-based stats.
 Identities = 63/425 (14%), Positives = 128/425 (30%), Gaps = 20/425 (4%)

Query: 5   RARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLT 64
           R +T L++ + A  +G+ + L+ +   +    +Q      L      A         +  
Sbjct: 28  RDKTPLIILIMAAVVGVVTGLLGVAFDRGVDWVQQQRLLALANVADYALLVWPLAFIMSA 87

Query: 65  LTGIAVGLVI-RFSQGHAGP-DPACEPLIGAPVP---PSALPGLIVALILGLAGGVSLGP 119
           L  +    ++ RF+    G   P  E  +    P      +P   +  +  L  G+ LG 
Sbjct: 88  LLAMMGYFLVSRFAPEAGGSGIPEIEGAMEEMRPVRWWRVIPVKFIGGLGTLGAGMVLGR 147

Query: 120 EHPIMTVNIALAVAIGA--RLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGS 177
           E P++ +       I    RL     R       +A  + A F  P+A  L   + +   
Sbjct: 148 EGPMVQMGGNSGRMIVDIFRLRSPEARHSLLATGAAAGLSAAFNAPLAGILFVIEEMRSQ 207

Query: 178 SEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAG 237
               L   + A  +      +    F      + +       +  +    ++  I  A G
Sbjct: 208 FRYSLV-SIKAVFIGVITSTIVYRYFNGERAIIEVGKLSDAPLNTLWLYLLLGIIFGAVG 266

Query: 238 MVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFK---GLDEMQQMVANQ 294
           ++    + R   M  +         +    L         +       G   +  + A  
Sbjct: 267 VIFNALIFRTQDMFVRFHGGDWRKLVLIGGLLGGMCGLLALLHGNAVGGGFALIPIAAAG 326

Query: 295 AFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPA------ 348
            FS      + + ++   ++   SG  GG   P + +G  LG                  
Sbjct: 327 NFSIGMLLFIFIARVITTLLCFGSGAPGGIFAPMLALGTILGTAFGLSCAHFFPQYGIEA 386

Query: 349 AITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL---AGKPMMM 405
                  +  +     R     + +   +  N  L+  + +  L A L+     GKP+  
Sbjct: 387 GTFAIAGMGALFAASVRAPLTGIVLVLEMTDNYQLILPMIVTCLGATLIAQFMGGKPLYS 446

Query: 406 VNRPK 410
               +
Sbjct: 447 AILAR 451


>UniRef50_Q1IME9 Cl-channel, voltage gated n=1 Tax=Candidatus Koribacter versatilis
           Ellin345 RepID=Q1IME9_ACIBL
          Length = 613

 Score =  205 bits (523), Expect = 2e-51,   Method: Composition-based stats.
 Identities = 58/399 (14%), Positives = 131/399 (32%), Gaps = 19/399 (4%)

Query: 11  LLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSP---LWIIGVLTLTG 67
           L+S  A  IG A+  +  ++  +     N+ +         +  +    LW+I V  + G
Sbjct: 25  LVSFLAAIIGTAAGFVAWLLYHLIGFFTNVAFYHTISFTFHSPRNHQLGLWVILVPVVGG 84

Query: 68  IAVGLVIRFS-----QGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHP 122
           + VG++ ++                  +  + + P       ++  + +  G   G E P
Sbjct: 85  LIVGVMAKYGSSKIRGHGIPEAMEAVLVNRSRIEPKVAILKPLSAAIAIGTGGPFGAEGP 144

Query: 123 IMTVNIALAVAIGARLLPRV-NRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVP 181
           I+    A+   IG  +      R       +A  + A F TP+AA ++  + +    +  
Sbjct: 145 IIQTGGAIGSLIGQVIQTTASERKVLLGCGAAAGMAATFSTPIAAVILAIELILFEFKA- 203

Query: 182 LWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAV 241
                   ++A+        +         +          +    ++ AI   + +   
Sbjct: 204 --RSFIPLVIASTIATSLHFVLMGRGPMFEVGAIDFGIPRVLPWYLLLGAICGFSAVGFS 261

Query: 242 WCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDY 301
             L  +     ++    +     G ++  +     P  L  G D +  ++ N        
Sbjct: 262 KLLYWVEDQFEKLPIDWMWWPAIGCVVLGVVGYFVPRVLGVGYDTISDIL-NTHLVFKVL 320

Query: 302 FLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVP------AVPAAITVSCA 355
             + + K   L+V   SG  GG + P      A+G  +   +        +  A     A
Sbjct: 321 LAVMIFKALVLLVTIGSGTSGGLLAPMFMASAAMGSAVAMIINHFIPGAGISPAAFALVA 380

Query: 356 ILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPA 394
           +  +    +R  +  +  A  +  +   +  L +V + A
Sbjct: 381 MGAVFGAASRATFAFIIFAFEITRDYNSILPLMLVAVIA 419


>UniRef50_C9LNJ2 Voltage-gated chloride channel family protein n=1 Tax=Dialister
           invisus DSM 15470 RepID=C9LNJ2_9FIRM
          Length = 545

 Score =  205 bits (523), Expect = 2e-51,   Method: Composition-based stats.
 Identities = 65/421 (15%), Positives = 138/421 (32%), Gaps = 24/421 (5%)

Query: 7   RTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQ------DSPLWII 60
           R  L L L  + +GIA  L++ +   +  +      +     +  +           W+ 
Sbjct: 33  RFRLRLFLEGILVGIAGGLLIALFRFLLGLADTYRRRLFQEIIIPSFGISDFLPLLWWLA 92

Query: 61  GVLTLTGIAVGLVIRFSQGHAGPDPACEPLIGAPVP---PSALPGLIVALILGLAGGVSL 117
            +  + G+  G+            P  + +I           L   I A  LG+  G+SL
Sbjct: 93  ALFFIGGVLYGMCRYAPMASGSGIPQVKGVILGFFKMKWFRILWVKITAGALGIGAGLSL 152

Query: 118 GPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNG 176
           G E P + +    A  +   +   R+         ++  + A F  P+A  +   + L+ 
Sbjct: 153 GREGPSIQIGAVAAQGLSRLMGRTRMEERYLITSGASAGLAAAFNAPLAGTMFALEELHR 212

Query: 177 SSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAA 236
           +        L   + +A +  + +  FF    S        +    +   A++A     A
Sbjct: 213 NFS---GAVLLPTMASAISATIVSQFFFGSATSFSFPLLVHLPSEYLWCVALIAVSCGFA 269

Query: 237 GMVAVWCLPRLHAMMH-QMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQA 295
           G+V  + L  + A     +     +  +       +     P  L  G   +  +   + 
Sbjct: 270 GIVFNYGLIHMDAFYGLPIFRSQYMKIMFALFAATILAFTLPDVLGGGNFLVDSLAKAR- 328

Query: 296 FSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEH------VPAVPAA 349
           +       L + K    +++   G  GG   P + +G  +G +  E       + A+   
Sbjct: 329 YGFGFLAALLLAKFLFTLISYGCGVPGGFFLPLLVIGALIGSLEGELLISAGILSALYLP 388

Query: 350 ITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWL---LLAGKPMMMV 406
             +  A++       R       +   +  +   L  L +    A++   LL G+P+   
Sbjct: 389 NIIIIAMVAFFAASIRAPITGTLLILEMTGDFHHLTALALASAVAYVTAELLKGQPIYDS 448

Query: 407 N 407
            
Sbjct: 449 L 449


>UniRef50_Q2BHE2 Cl-channel, voltage gated n=1 Tax=Neptuniibacter caesariensis
           RepID=Q2BHE2_9GAMM
          Length = 574

 Score =  205 bits (522), Expect = 3e-51,   Method: Composition-based stats.
 Identities = 54/408 (13%), Positives = 116/408 (28%), Gaps = 17/408 (4%)

Query: 11  LLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAV 70
            + +  +  G+   ++L     +  V    L           + S  +   +  +  + +
Sbjct: 23  QMVVLGIICGLLCGVVLGSFRLLLEVPLAHLLPGGESE-NFEELSGWYHFFLPVIGSLII 81

Query: 71  GLVIRF-----SQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMT 125
             ++        +              + +P        +     L  G S+G E P + 
Sbjct: 82  IAILSRVTPLTRKVGVTHLLERMAYHQSNLPLKNAIVQFLTASTALLFGHSVGKEGPAIH 141

Query: 126 VNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWD 184
           +       +G +L LP           +A  I A F TP+A  +   + +     V    
Sbjct: 142 LGATCGSQLGQKLNLPNNTLRILAGCGTAAGIAATFNTPLAGVVFAMEVVLLEYTV---I 198

Query: 185 RLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCL 244
                ++AAA GAL     F     L +       +++I   A +  +     +  +  +
Sbjct: 199 GFMPVMVAAATGALVMQFMFGQELVLTVPAMQIESLSEIPYVAFLGGMIGLLAVAFISLM 258

Query: 245 PRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLL 304
                             I   +      +  P  +  G D +  ++  +         +
Sbjct: 259 RETMRWSDHSVLTYKTKLIIAGLFTGSVAVFVPQVMGVGYDTVTSVLNGE-LGLGILIAI 317

Query: 305 AVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHV------PAVPAAITVSCAILG 358
            + K     V    G   G I P  F+G   G +L                      +  
Sbjct: 318 LIAKCLLTPVVLGLGIPAGLIGPTFFIGAIAGGLLGILGAGAVNEQVANPGFYALLGMGS 377

Query: 359 IVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMV 406
           ++  V      +L     +  N  ++    I ++ + L+      M  
Sbjct: 378 MMGAVANAPMAALVAILELTGNPNIIFPAMISIVVSNLIARYVFNMPS 425


>UniRef50_A6GII6 Putative chloride channel n=1 Tax=Plesiocystis pacifica SIR-1
           RepID=A6GII6_9DELT
          Length = 866

 Score =  205 bits (521), Expect = 3e-51,   Method: Composition-based stats.
 Identities = 67/412 (16%), Positives = 134/412 (32%), Gaps = 23/412 (5%)

Query: 9   MLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGI 68
            L L L AV +G+AS     +++   +    +                +++I    L G+
Sbjct: 208 HLYLLLMAVVVGVASGAAAGLLLLWIARAVEIF---PAVGNAFPSFGWIYLILAPALGGL 264

Query: 69  AVGLVIRFSQGHAGPDPACEPL------IGAPVPPSALPGLIVALILGLAGGVSLGPEHP 122
            VG +   ++   G  P   P           +   A   L +   + +A G S+G E P
Sbjct: 265 LVGGLRALARRTLGDIPEGIPAVIEAVGHQKKLSGRAGSLLGLGTGITIASGGSVGHEGP 324

Query: 123 IMTVNIALAVAIGARLLPRVNRME-WTILASAGTIGALFGTPVAAALIFSQTLNGSS--- 178
            + +   +   +      R+ R         A  + A F  P+A  +   + +   S   
Sbjct: 325 TVAIGATVGSVLARFFGLRMRRQTTMLGAGCAAGLAAAFNAPLAGVIFTVEVVFKRSIGT 384

Query: 179 EVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQME--MTDILSGAIVAAIAIAA 236
            +         ++AA AG  T+   F     L      + E  + +++    +A IA   
Sbjct: 385 TLGSMSVFTPLIVAAVAGTFTSHAIFGERTELVTPGDVEGERILAEMIFFLALAVIAGLL 444

Query: 237 GMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIG-GPVSLFKGLDEMQQMVANQA 295
             +    +     +  ++K P       G +   L         L  G D + + + +  
Sbjct: 445 SPLMSRAILFSSDLFERLKIPDWTKPAIGGLGVGLLGTLLFTDLLGPGRDTVFEAL-HSE 503

Query: 296 FSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVP------AA 349
            +       A +K+ A  +   SG  GG   P++ +G  +G  +H     V        A
Sbjct: 504 LAWQIALAFAFLKIFATALTIGSGGMGGVFMPSLVIGACVGTSVHALAQLVFGEHVSQPA 563

Query: 350 ITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGK 401
                 +   +    R     + M   +  +  L+  L    + +  +    
Sbjct: 564 AYALVGMGAYLGATLRAPLTPIVMIFELTGDYGLILPLMFACILSAFVAGRV 615


>UniRef50_D1W6U8 Chloride transporter, ClC family n=16 Tax=Bacteroidales
           RepID=D1W6U8_9BACT
          Length = 595

 Score =  205 bits (521), Expect = 4e-51,   Method: Composition-based stats.
 Identities = 58/431 (13%), Positives = 132/431 (30%), Gaps = 41/431 (9%)

Query: 14  LPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLV 73
           + A  IGI +S+   V+  I   +Q+LL      T           +    +      L 
Sbjct: 26  ILAFFIGIFASVAAYVLHFIIRQIQHLLTAGFDATT-----YNWLYLLFPVIGIYITSLF 80

Query: 74  IRF-----SQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNI 128
           +R+                     + +        +++  + +  G S+G E PI+    
Sbjct: 81  VRYVVKDNISHGITQVLYAISTKQSRLKAHNCWTSVISSAITIGFGGSVGAEAPIVLTGS 140

Query: 129 ALAVAIGARLLPRVNRMEWTI-LASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLF 187
           A+   +G         +   +   ++  I  +F  P+A  +   + L     +     L 
Sbjct: 141 AIGSNLGQLFKMDNKTLMLLVGCGASAAIAGIFKAPIAGLVFTLEVLMVDLSMA---SLL 197

Query: 188 APLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRL 247
             L +     + T +F                +  I +  ++        +  +  + + 
Sbjct: 198 PILTSTVTATVFTYIFVGNRSLFDFTLDSAWNIDRIPASILLGLFCGMVSLYFIRMMSKC 257

Query: 248 HAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQA------------ 295
             +  Q+K+        G IL    +   P    +G + +  ++                
Sbjct: 258 EGVFEQLKDYPFAKLFLGAILLSSLIFFFPSLYGEGYNSLNILLNGNTEADWNAVMNNSL 317

Query: 296 ------FSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPA---- 345
                        L+ + K+ A      +G  GG   P++FVG   G +           
Sbjct: 318 FAGSSGLLVIYIALVLLTKIFATSATNGAGGVGGTFAPSLFVGGFGGFLFARVWNMNQVG 377

Query: 346 --VPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLA---G 400
             +P        + G++  V       +F+ A +    +L   L +V + + ++++    
Sbjct: 378 TYIPEKNFTLLGMAGVMAGVMHAPLTGVFLIAELTGGYSLFLPLIMVSIVSVMVISIFEP 437

Query: 401 KPMMMVNRPKQ 411
             +      +Q
Sbjct: 438 HSIYATRLARQ 448


>UniRef50_A7HL32 Chloride channel core n=1 Tax=Fervidobacterium nodosum Rt17-B1
           RepID=A7HL32_FERNB
          Length = 518

 Score =  204 bits (520), Expect = 4e-51,   Method: Composition-based stats.
 Identities = 60/419 (14%), Positives = 153/419 (36%), Gaps = 23/419 (5%)

Query: 6   ARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTL 65
           AR    L L ++A+GI SSL++I+   + +   ++  +               I+ ++ +
Sbjct: 14  ARLKSKLILKSIAVGIFSSLMVILYRIMLTKADSIR-EYALHMYNSNHLYIFLILFLVVI 72

Query: 66  TGIAVGLVIRFSQGHAGP-DPACEPLIGAPVPP---SALPGLIVALILGLAGGVSLGPEH 121
             + +   ++     +G   P  + +I   +      A+   ++   L +  G+SLG E 
Sbjct: 73  NSLIIKKFVKTEPMISGSGIPQIKGVILRQIDYNPIKAIYKKLIGGFLAILNGLSLGREG 132

Query: 122 PIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEV 180
           P + +   + +    +L L ++         ++  + A F  P+AA +   + L+ +   
Sbjct: 133 PSVQIGATVGMYFSRKLELTKMEEKYLITAGASAGLAAAFNAPLAAVIFSLEELHKNFSP 192

Query: 181 PLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVA 240
                L   ++AA      +   F             + +       ++  +    G+  
Sbjct: 193 M---VLLTSMIAAIVSDFISKTVFGLKPVFNFQLSSTIPLKYYPFLILLGFVTGILGVYF 249

Query: 241 VWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSD 300
              L +   +  +++N +    +   ++G++ ++  P  L  G D + +  +    +   
Sbjct: 250 NKSLLKSTQVFKKIENRI----LISSLIGVVLLLTIPDVLGGGHDLVIK-TSKVNITLKQ 304

Query: 301 YFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLML--HEHV----PAVPAAITVSC 354
             ++ VIK A  +++ AS   GG   P + +G  +G        +            ++ 
Sbjct: 305 ILIILVIKFAFTMISYASSAPGGIFLPMLALGALIGKAFYSGIFIFFDTNNTYMVNFITL 364

Query: 355 AILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGK---PMMMVNRPK 410
            ++G  + + R     + +   +V        L +V   +++        P+      +
Sbjct: 365 GMVGYFVAIVRAPITGIVLITEMVGTLNHFLELSLVSFVSYITAELLNEEPIYESLLER 423


>UniRef50_B7G9G8 Predicted protein n=1 Tax=Phaeodactylum tricornutum CCAP 1055/1
           RepID=B7G9G8_PHATR
          Length = 1260

 Score =  204 bits (520), Expect = 5e-51,   Method: Composition-based stats.
 Identities = 75/436 (17%), Positives = 147/436 (33%), Gaps = 33/436 (7%)

Query: 13  SLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTG--IAV 70
           ++ A+ IG    +   +         + LW  LP    I        +  + L G  +AV
Sbjct: 87  AVLALTIGCVCGVAAWLYYMFLEWALDFLWHDLPERFVIDYWPEYLYVLWIPLIGFGMAV 146

Query: 71  GL-VIRFSQGHAGPDPACEPLIG--APVPPSALPGLIVALILGLAGGVSLGPEHPIMTVN 127
           GL ++    G  G  P     +     V  + +  +++A    +  G SLGPE P++ + 
Sbjct: 147 GLGIVVKVMGEPGDLPYTVKCVHEKGYVAMNHVMPMVMASQCSILAGGSLGPEAPLVAIC 206

Query: 128 IALAVAIGARLLPRVNR---MEWTILASAGTIGALFGTPVAAALIFSQTLNG---SSEVP 181
            AL   +   +    +R    + T++  AG + A FG P+  +L   +  +         
Sbjct: 207 AALGGFVSRSVFGMTDRNLVRKHTLMGMAGALAAFFGCPLGGSLFAMEVNSRFGIEYFEH 266

Query: 182 LWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAV 241
             + +    +         GL     + +         + DIL G ++  +         
Sbjct: 267 TLEAILCGEICLVVFRALAGLPIQAIWDISDDKLEATSVVDILYGCVLGLLGAGVAWGFA 326

Query: 242 WCLPRLHAMMHQMKN----PVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAF- 296
               ++  M            +   + G ++ +L  +  P ++F G  E + +       
Sbjct: 327 NFHWKVMHMFQHFNLLKNERAIHRAMAGAVVVVLMGMLVPQTMFWGEFEFETIATMAPTK 386

Query: 297 -----------------STSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLML 339
                            S     ++ V KL A+    + G+RGG IFPA     ALG  +
Sbjct: 387 DLMHIWPTSGLLGFEMDSFGSAMIVGVAKLIAISFTVSGGYRGGYIFPAFAAAAALGRAI 446

Query: 340 HEHVPAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLA 399
               P +P  + V C    + + +TR    +  + A +      +  +    L +     
Sbjct: 447 SILCPFIPVQLCVLCMAAALNVALTRTALATTLILAYLSGEQNSISAILAASLVSLFATG 506

Query: 400 GKPMMMVNRPKQQPPH 415
             P +     +     
Sbjct: 507 YMPFIRSQMVRADLDA 522


>UniRef50_B2K549 H(+)/Cl(-) exchange transporter clcA n=40 Tax=Gammaproteobacteria
           RepID=CLCA_YERPB
          Length = 478

 Score =  204 bits (520), Expect = 5e-51,   Method: Composition-based stats.
 Identities = 63/425 (14%), Positives = 128/425 (30%), Gaps = 20/425 (4%)

Query: 5   RARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLT 64
           R +T L++ + A  +G+ + L+ +   +    +Q      L      A         +  
Sbjct: 28  RDKTPLIILIMAAVVGVVTGLLGVAFDRGVDWVQQQRLLALANVADSALLVWPLAFIMSA 87

Query: 65  LTGIAVGLVI-RFSQGHAGP-DPACEPLIGAPVP---PSALPGLIVALILGLAGGVSLGP 119
           L  +    ++ RF+    G   P  E  +    P      +P   +  +  L  G+ LG 
Sbjct: 88  LLAMMGYFLVSRFAPEAGGSGIPEIEGAMEEMRPVRWWRVIPVKFIGGLGTLGAGMVLGR 147

Query: 120 EHPIMTVNIALAVAIGA--RLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGS 177
           E P++ +       I    RL     R       +A  + A F  P+A  L   + +   
Sbjct: 148 EGPMVQMGGNSGRMIVDIFRLRSPEARHSLLATGAAAGLSAAFNAPLAGILFVIEEMRSQ 207

Query: 178 SEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAG 237
               L   + A  +      +    F      + +       +  +    ++  I  A G
Sbjct: 208 FRYSLV-SIKAVFIGVITSTIVYRYFNGERAIIEVGKLSDAPLNTLWLYLLLGIIFGAVG 266

Query: 238 MVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFK---GLDEMQQMVANQ 294
           ++    + R   M  +         +    L         +       G   +  + A  
Sbjct: 267 VIFNALIFRTQDMFVRFHGGDWRKLVLIGGLLGGMCGLLALLHGNAVGGGFALIPIAAAG 326

Query: 295 AFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPA------ 348
            FS      + + ++   ++   SG  GG   P + +G  LG                  
Sbjct: 327 NFSIGMLLFIFIARVITTLLCFGSGAPGGIFAPMLALGTILGTAFGLSCAHFFPQYGIEA 386

Query: 349 AITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL---AGKPMMM 405
                  +  +     R     + +   +  N  L+  + +  L A L+     GKP+  
Sbjct: 387 GTFAIAGMGALFAASVRAPLTGIVLVLEMTDNYQLILPMIVTCLGATLIAQFMGGKPLYS 446

Query: 406 VNRPK 410
               +
Sbjct: 447 AILAR 451


>UniRef50_B5JKG4 Chloride transporter, ClC family, putative n=1 Tax=Verrucomicrobiae
           bacterium DG1235 RepID=B5JKG4_9BACT
          Length = 627

 Score =  203 bits (518), Expect = 7e-51,   Method: Composition-based stats.
 Identities = 77/418 (18%), Positives = 147/418 (35%), Gaps = 31/418 (7%)

Query: 14  LPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLW-IIGVLTLTGIAVGL 72
           + A+ IGI S L  +   K     ++     +     I     +  +I +    G+ VG 
Sbjct: 65  VLAILIGILSGLSAVAFHKSIHWAEH---NWIYRVSQIPGWLGVLGLIFLPAFGGLVVGF 121

Query: 73  VIRFSQ--GHAGPDPACEP---LIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVN 127
           +I++          P  +    L    +   A  G  +     +  G SLG E P + ++
Sbjct: 122 LIKYWAPEAAGSGIPQVKAAYFLKFGRIRFRAALGKFILGTASIGTGASLGREGPTVHLS 181

Query: 128 IALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRL 186
            A+A  +G    L     M    L  AG I A F TP+AA +   + + G  +       
Sbjct: 182 AAIASWVGRWFGLAPRQVMALIPLGCAGGIAAAFNTPLAAIVFAIEEIMGDLK---HKAF 238

Query: 187 FAPLMAAAAGALTTGLFFHPHFSLPIA-HYGQMEMTDILSGAIVAAIAIAAGMVAVWCLP 245
              +M A   A+             +  H   +    +    ++  IA       V C+ 
Sbjct: 239 AGIVMVAVIAAVIERSLLGTDAMFQVPFHPDHLSGLGLAMSLVLGVIAGFVSHAFVECML 298

Query: 246 RLHAMMH--QMKNPVLVLGIGGFILGILGVIGGPV-----SLFKGLDEMQQMVANQAFST 298
           +    +   + K   ++ G+GG + G +G +             G  ++ + +A  + S 
Sbjct: 299 KARERVKLVRGKYSWMMPGVGGLLTGCVGALVFKNLGHMGVFGIGYLDLSEALAG-SLSL 357

Query: 299 SDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVP------AAITV 352
                L V K A+ + + +SG  GG   P +F+G  LG  L      V         +  
Sbjct: 358 GVLVALFVGKFASTIFSYSSGGSGGIFAPTLFIGAMLGGALGVLTEMVSGQAGLLPHVLA 417

Query: 353 SCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLA---GKPMMMVN 407
              +  +   V R    S+ +   +  +  L+  + +  L ++ + +     P+    
Sbjct: 418 LVGMGALFAGVIRAPVTSILIIFELTRDYNLILPIMVANLTSYAIASKLRQVPIYEAL 475


>UniRef50_C0W1S0 H(+)/Cl(-) exchange transporter n=1 Tax=Actinomyces coleocanis DSM
           15436 RepID=C0W1S0_9ACTO
          Length = 501

 Score =  203 bits (518), Expect = 8e-51,   Method: Composition-based stats.
 Identities = 76/405 (18%), Positives = 147/405 (36%), Gaps = 16/405 (3%)

Query: 6   ARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTL 65
           AR++ LL   A  +GI++ LI          +  L +  +    G A    +  I V T+
Sbjct: 42  ARSLFLLCFAAALVGISTGLIAASFRIGLEWVLELRFGLIDLLDGQAVLGFILFIAVTTI 101

Query: 66  T-GIAVGLVIRFSQGHAGP-DPACEPLIGAPVPP---SALPGLIVALILGLAGGVSLGPE 120
             G++  LV + S    G   P  E ++   + P     LP   V  ++ +  G+ LG E
Sbjct: 102 LTGLSALLVAKVSPDAEGSGIPRVEAIVNGHLEPGRSRILPVKFVGGLMAIGSGLMLGRE 161

Query: 121 HPIMTVNIALAVAIGARLLPRVNR-MEWTILASAGTIGALFGTPVAAALIFSQTLNGSSE 179
            P++ +  + A  +      + +         +A  +   F  P+A  +   + L    +
Sbjct: 162 GPLVQMGASAAYTVNKYFRLKDDDLRVLMGAGAAAGLATAFNAPIAGGVFVLEELLKRFD 221

Query: 180 VPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMV 239
           +       A L+A+ AG +++ L     F   I    Q+  T I    ++  +    G++
Sbjct: 222 I---RTTLATLVASGAGFVSSILLVDSRFEFIIGWAPQVTNTSIHWVVLIGILCGFLGII 278

Query: 240 AVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTS 299
               +         +K P  + G    ++  +     P  +  G +  QQ +        
Sbjct: 279 YNDYVMWCLRFADTLKPPAFIRGGVVGLVLGIVGWFAPAIVGGGDNLTQQALLGNGGLGL 338

Query: 300 DYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPA------AITVS 353
              +LAV +     ++ A+G  GG   P + +G  LG+++     +V             
Sbjct: 339 AVAILAV-RFILGPISYAAGTPGGLFAPQLVIGSTLGMIIGIIANSVQPNHSPSVPAAAL 397

Query: 354 CAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL 398
             +        R     L +A+ +  N T LP +      A  + 
Sbjct: 398 IGLSAFFSATVRTPITGLILASEMTGNVTALPAMLAACAVAMYIA 442


>UniRef50_C7PH71 Chloride channel core n=2 Tax=Bacteroidetes RepID=C7PH71_CHIPD
          Length = 614

 Score =  203 bits (517), Expect = 9e-51,   Method: Composition-based stats.
 Identities = 65/420 (15%), Positives = 137/420 (32%), Gaps = 26/420 (6%)

Query: 2   LHPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIG 61
           LH        L L  + +G+ + +  +++  +   +   +  R+  +  +   +    +G
Sbjct: 38  LHKVLSRSQFLILSGILVGLVAGMAGVILKVLVHYIHYFITYRVHFSTQVIFYALFPFLG 97

Query: 62  VLTLTGIAVGLVIRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEH 121
           +L  T + V +    S+   G          + +P   +   I+   + +  G S G E 
Sbjct: 98  ILLTTILVVWVFKGQSRKGIGLILYEIAQNSSKIPSVKMYSQILQSAITVGLGGSAGLES 157

Query: 122 PIMTVNIALAVAIGARLLPRVNRMEWTILASAGTIGAL-FGTPVAAALIFSQTLNGSSEV 180
           PI     A+                  + A A    A  F  P+A  +   + L      
Sbjct: 158 PIAVTGAAIGSNYATNYNLGYKERTLLLAAGATAGIAASFNAPIAGVMFAFEILLTGV-- 215

Query: 181 PLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVA 240
            ++      ++AA  G+L + +                   ++     +  ++       
Sbjct: 216 -VFSDFIPLILAAICGSLLSKIILQEEVLFHFETRQPFNYHNVPFYIALGLLSALYARYY 274

Query: 241 VWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQA----- 295
           +     +   M ++K P L   I G ++  +  +  P    +G   ++ +    +     
Sbjct: 275 IVISQHVEHFMVKLKWPALRKAILGGVIVSILCVLMPPLFGEGYSSLKLLTGGFSDQIIQ 334

Query: 296 ------FSTSDYFLLA------VIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEH- 342
                      + LLA      ++K+ A       G  GG   P++F G  LG       
Sbjct: 335 NSFFRYLPEKSWILLAFTGFTCLLKVFATSFTIQGGGNGGNFAPSLFAGGFLGYFFALLC 394

Query: 343 ----VPAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL 398
                  VP A  V   + G++  V      ++F+ A       L   L IV   ++++ 
Sbjct: 395 TNFGFQDVPFANLVLVGMAGVMSGVMYAPLTAIFLIAESSFGYDLFIPLMIVSTISFVVA 454


>UniRef50_D0KW58 Cl-channel voltage-gated family protein n=1 Tax=Halothiobacillus
           neapolitanus c2 RepID=D0KW58_HALNC
          Length = 604

 Score =  203 bits (517), Expect = 9e-51,   Method: Composition-based stats.
 Identities = 74/400 (18%), Positives = 138/400 (34%), Gaps = 19/400 (4%)

Query: 12  LSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVG 71
           +++  +  GI +S ++ +       LQ      LP     +     W   + TL GI +G
Sbjct: 25  MAILGLFAGIVASALVTLFRFTLESLQIYFLG-LPSPDNYSALPIEWRFWLPTLGGIILG 83

Query: 72  LVIRFSQGHA-----GPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTV 126
           +        A     G          A +P         + + GL  G+S G E P + +
Sbjct: 84  VAFMLIPQAARAVGVGFVIIRFHRSQADLPWPNAIVQFFSAVWGLLVGLSNGREGPGVHL 143

Query: 127 NIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDR 185
                  +G RL LP+ +        +A  I A F TP+AA ++  + +     +     
Sbjct: 144 GATAGSLLGQRLDLPQNSVRTLVGCGAAAAIAASFNTPLAAVILVLELIVRQYTLA---T 200

Query: 186 LFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLP 245
               ++A++AGAL + LFF  + +  I  Y  + + +I    ++  +  A          
Sbjct: 201 FIPIILASSAGALFSTLFFGDNPAFNIQLYHSLALWEIPVLVLLGLVIGAFSAAYTHIAE 260

Query: 246 RLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLA 305
               +    K PV +      I+  L  +  P  +    D +  + A   F+      L 
Sbjct: 261 VS--IHRTWKWPVWLRFGLIGIITGLVGMYLPQIMSISYDSV-GLAAGAKFTLLLLLFLI 317

Query: 306 VIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHV------PAVPAAITVSCAILGI 359
           V KL    +    G   G I P + +G   G      +      P    A      +  +
Sbjct: 318 VAKLLLSALTLGFGLPLGSIGPTLVIGGFTGSAFGTVLLSFTQIPISDVAYYTVLGMGAM 377

Query: 360 VLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLA 399
           +    +    +L     +  +T  +    + ++ A L   
Sbjct: 378 MGATLQAPLAALTAVIELTGDTGTIMPAMVTIIIASLTSR 417



 Score = 63.7 bits (154), Expect = 1e-08,   Method: Composition-based stats.
 Identities = 33/217 (15%), Positives = 64/217 (29%), Gaps = 21/217 (9%)

Query: 17  VAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRF 76
           V +G+           IA V  +  W+             L    +  +TG+    + + 
Sbjct: 242 VLLGLVIGAFSAAYTHIAEVSIHRTWKW---------PVWLRFGLIGIITGLVGMYLPQI 292

Query: 77  SQGHAGPD-PACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIG 135
                     A        +    +   ++   L L  G+ LG   P + +      A G
Sbjct: 293 MSISYDSVGLAAGAKFTLLLLLFLIVAKLLLSALTLGFGLPLGSIGPTLVIGGFTGSAFG 352

Query: 136 ARLL-----PRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPL 190
             LL     P  +   +T+L     +GA    P+AA     +    +        +   +
Sbjct: 353 TVLLSFTQIPISDVAYYTVLGMGAMMGATLQAPLAALTAVIELTGDT------GTIMPAM 406

Query: 191 MAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGA 227
           +     +LT+   F          +   +   +LS  
Sbjct: 407 VTIIIASLTSRTLFGKDGIYDAVLFANSQQLRLLSLW 443


>UniRef50_A8F4B4 Chloride channel core n=1 Tax=Thermotoga lettingae TMO
           RepID=A8F4B4_THELT
          Length = 523

 Score =  203 bits (517), Expect = 9e-51,   Method: Composition-based stats.
 Identities = 55/399 (13%), Positives = 127/399 (31%), Gaps = 22/399 (5%)

Query: 11  LLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAV 70
            L   +   G  S L++++     +  +N+       ++        WI   +  + I  
Sbjct: 25  KLIFKSFLTGAVSGLVVVLYRLSITCAENIR-----SSIKYGSWFIFWIFMTVGFSLIIW 79

Query: 71  GLVIRFSQGHAGPDPACEPLIGAPVPP---SALPGLIVALILGLAGGVSLGPEHPIMTVN 127
            +  +    +    P    ++   +       L G      L +  G SLG E P + + 
Sbjct: 80  WITKKVPHVNGSGIPQVRAILLRKINYEPLKVLLGKFFGGFLAIINGFSLGREGPSVQIG 139

Query: 128 IALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRL 186
            ++ +    +     + +    +  S+  + A F  P AA +   + L  +        L
Sbjct: 140 ASVGLIFSNKFAKNDLEKKHMIVAGSSAGLAAAFNAPFAAVIFSIEELQRNISP---LTL 196

Query: 187 FAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPR 246
              ++AA      + + F       +     + +        +  +    G      +  
Sbjct: 197 LTSMIAAITAGYISKVVFGVAPIFDLKLSSVLPLKYYPLILGLGVVIGIFGAFFTKSILW 256

Query: 247 LHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAV 306
               M ++K   +   +   I     ++  P  L  G + +  +     FS     +L V
Sbjct: 257 FSEQMGKLK---VFSLMIPTIAAWFFLLKIPQVLGGGHELIMDVAHG-LFSAKMLIVLLV 312

Query: 307 IKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEH------VPAVPAAITVSCAILGIV 360
           +K    +++  S   GG   P + +G  +G   +                 V   +    
Sbjct: 313 LKFYFTMISYGSKAPGGIFLPMLAIGALIGSAYYHLINVFWNFNDSYLTNFVVLGMASYF 372

Query: 361 LVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLA 399
             V R     + +   +V +   L  L +V + A+++ +
Sbjct: 373 ASVVRAPITGIALVTELVGSFNHLLSLSVVSISAYIISS 411


>UniRef50_C8NG64 Voltage-gated chloride channel family protein n=2 Tax=Firmicutes
           RepID=C8NG64_9LACT
          Length = 515

 Score =  203 bits (517), Expect = 1e-50,   Method: Composition-based stats.
 Identities = 67/409 (16%), Positives = 132/409 (32%), Gaps = 16/409 (3%)

Query: 2   LHPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIG 61
           L+PR             IG+ +   + +   +   +   +           Q  P WI+ 
Sbjct: 7   LNPRRYRKSGYIAIGALIGVLAGSAVSLFRYMIGFILEQVVTVYSFLREQPQWIPAWILF 66

Query: 62  VLTLTGIAVGLVIRFSQGHAGPDPACEPLIGAPVPPSAL---PGLIVALILGLAGGVSLG 118
            L +  I   +V           P  E  +   +  +         V   + +  G+ LG
Sbjct: 67  SLVMGVILGQIVKSDPDIKGSGIPQVELQLQGKMDMNWWSVCWKKFVGGAISIGSGLLLG 126

Query: 119 PEHPIMTVNIALAVAIGARLLP-RVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGS 177
            E P + +  ++   +       RV +  +    +   + A F  P+A  +   + ++ +
Sbjct: 127 REGPSIQLGASVGQGVAETFKANRVQKNVFISSGAGAGLAAAFNAPIAGLMFVLEEVHHT 186

Query: 178 SEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAG 237
                       L AA      +   F  H SL + +  +  M       ++  +    G
Sbjct: 187 FSP---LVAVTTLTAAIVANFISLNVFGTHPSLNLGNDQRFPMEYYGYVVLLGIVLAIFG 243

Query: 238 MVAVWCLPRLHAMMHQM--KNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQA 295
           +        L  +   +  K       +  F+L I   I  P  L  G + +  +V    
Sbjct: 244 LAYHRLTLALPKIYKTLFPKVAPYNYCLIAFMLIIPLGIWNPHVLGGGGELVLALVKENH 303

Query: 296 FSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPA------A 349
            +      L VI+    +++  +G  GG   P + +G  LGL   E +            
Sbjct: 304 -TVQFLVGLFVIRFVYSMISYGTGLPGGIFLPILSLGALLGLAYAEFLIEFLGVDPSVRV 362

Query: 350 ITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL 398
             V  A+ G    + +    +L +   +V     L  L I  L A+++ 
Sbjct: 363 SFVFFAMAGYFAAIGKAPLTALLLVTEMVGGLNQLMPLGICTLVAYIVA 411


>UniRef50_UPI0001972FFA chloride channel protein EriC n=1 Tax=Clostridium sp. M62/1
           RepID=UPI0001972FFA
          Length = 418

 Score =  203 bits (517), Expect = 1e-50,   Method: Composition-based stats.
 Identities = 69/406 (16%), Positives = 146/406 (35%), Gaps = 27/406 (6%)

Query: 9   MLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGI 68
            +  S  +V IG+++ LI            N                  W I  L +TG+
Sbjct: 17  FVKWSAISVLIGLSTGLIGTAFGHCVLWAGNYFRTNR------------WSIYFLPVTGL 64

Query: 69  AVGLVIRFSQ--GHAGPDPACEPLI-GAPVPPSALPGLIVALILGLAGGVSLGPEHPIMT 125
            +  +    +   + G +   E +   + +     P + +  +L    G S G E   + 
Sbjct: 65  LIVWIYHILKEDKNRGTNMVIESIYTNSDISLGMAPAVFLGTVLTHFSGGSAGREGAALQ 124

Query: 126 VNIALAVAIGARLLPRV-NRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWD 184
           +  ++   IG  +     ++    +   +G   ALFGTP+AAA+   + +  S  V  + 
Sbjct: 125 MGGSIGNQIGKLMKLDEKDKKIAVMCGMSGAFAALFGTPMAAAVFSMEVI--SIGVMYYA 182

Query: 185 RLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCL 244
            L   + +A  GA  +        + PI    +  +   L   ++  +      +    L
Sbjct: 183 ALVPCVFSAFIGAAVSSHLGLKAEAFPIGEIPEFGLKMALLIIVLGLLCALVSELFCIVL 242

Query: 245 PRLHAMMHQ-MKNPVLVLGIGGFILGILGVIGGPVSL-FKGLDEMQQMVANQAFSTSDYF 302
            R   +  +    P   +  GGF++ +L ++ G +     G+  ++Q    +    +  +
Sbjct: 243 HRTARIYEKYFPTPNKRVIAGGFLVIVLTILVGNIDYNGSGIHLIEQCFEGEVRYEAFLW 302

Query: 303 LLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLV 362
                K+    V   +GF+GG I P   +G   G      +   P  +  +C +L + + 
Sbjct: 303 -----KILFTAVTLEAGFKGGEIVPTFCIGATFGCTFA-MLTGQPHGLMAACGMLALFVG 356

Query: 363 VTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNR 408
           VT     +L +   +      +P   + +  ++ L     +    +
Sbjct: 357 VTNCPISTLLIGFEMFG-YEAMPYFVLSIAVSFTLSGYYGLYSSQK 401



 Score = 57.1 bits (137), Expect = 1e-06,   Method: Composition-based stats.
 Identities = 21/186 (11%), Positives = 56/186 (30%), Gaps = 6/186 (3%)

Query: 227 AIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDE 286
            ++       G     C+          +  +  L + G ++  +  I            
Sbjct: 25  VLIGLSTGLIGTAFGHCVLWAGNYFRTNRWSIYFLPVTGLLIVWIYHILKEDKNRGTNMV 84

Query: 287 MQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAV 346
           ++ +  N   S      + +      V+   SG   GR   A+ +G ++G  + + +   
Sbjct: 85  IESIYTNSDISLGMAPAVFLG----TVLTHFSGGSAGREGAALQMGGSIGNQIGKLMKLD 140

Query: 347 PAA--ITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMM 404
                I V C + G    +      +   +  V+    +     +  + +  + A     
Sbjct: 141 EKDKKIAVMCGMSGAFAALFGTPMAAAVFSMEVISIGVMYYAALVPCVFSAFIGAAVSSH 200

Query: 405 MVNRPK 410
           +  + +
Sbjct: 201 LGLKAE 206


>UniRef50_C0YIY4 Chloride carrier/channel (ClC) family transporter n=3
           Tax=Bacteroidetes RepID=C0YIY4_9FLAO
          Length = 435

 Score =  203 bits (516), Expect = 1e-50,   Method: Composition-based stats.
 Identities = 70/410 (17%), Positives = 136/410 (33%), Gaps = 24/410 (5%)

Query: 4   PRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVL 63
           P    +L     ++ IG          ++    + N             +++ LW+I  L
Sbjct: 24  PALPYILKWLFISMIIGALVGTASAGFLQSLEWVTNF------------RENHLWLIAFL 71

Query: 64  TLTGIAVGLVIRFSQG----HAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGP 119
            + G  +GL+  +                      +P    P + +  I     G S G 
Sbjct: 72  PVAGFLIGLLYYYFGKDVEAGNNLLIDTIHEPKGIIPFKMAPFVYLGTIATHFFGGSAGR 131

Query: 120 EHPIMTVNIALAVAIGARLLP-RVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSS 178
           E   + +  A+A  +       R +R    I A A   G++FGTP+A A+   +      
Sbjct: 132 EGTALQMAGAIADQLTKPFKLDRNDRKVLIISAIAAGFGSVFGTPLAGAVFGLEVFL--I 189

Query: 179 EVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGM 238
               ++ +F    +A    L T L+   H    I    ++E   IL   +          
Sbjct: 190 GRIRYNAIFPAFASAVLADLVTNLWKVKHTHYHIDFVPKLEFLPILYSILAGIAFGICAA 249

Query: 239 VAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFST 298
                +  + +          +  + G I+  L V     + + GL     M   ++F  
Sbjct: 250 AFSKIIHWMGSFFKSKVKYPPLRPVAGGIIIALAVFAMGTTRYIGLGIPMIM---ESFEK 306

Query: 299 SDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILG 358
                   +K+   +V  ++GF+GG + P  F+G  LG  L   +P +P  +      + 
Sbjct: 307 QLPLYDFALKMIFTIVTLSAGFKGGEVTPLFFIGATLGSALSLFIP-LPFGLLAGMGFVA 365

Query: 359 IVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNR 408
           +    T      + M   +         + I  + ++LL     +    +
Sbjct: 366 VFAGATNTPLACMLMGIELFG-AECGVYVAIACVVSYLLSGHNSIYAKQK 414


>UniRef50_A5VII6 Chloride channel, core n=18 Tax=Lactobacillaceae RepID=A5VII6_LACRD
          Length = 516

 Score =  203 bits (516), Expect = 1e-50,   Method: Composition-based stats.
 Identities = 57/390 (14%), Positives = 130/390 (33%), Gaps = 15/390 (3%)

Query: 8   TMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTG 67
                 + A+ IGI + L++ V   I      L+                W IG + L  
Sbjct: 12  NQFNQLIRAIIIGILTGLVVSVFRLIIQHFLQLVTASFAYFHSHPLWLIPWTIGSIILAL 71

Query: 68  IAVGLVIRFSQGHAGPDPACEPLIGAPVPPSALPG---LIVALILGLAGGVSLGPEHPIM 124
           +   L   +        P  E  +         P      +  I  +  G+ LG E P +
Sbjct: 72  LLGWLAQSYPDIKGSGIPQVEGQLTNQFDEKWWPVLWRKFLGGIFAIGSGLYLGREGPSI 131

Query: 125 TVNIALAVAIGARLLPRVNRMEW-TILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLW 183
            +   +   +  +        +      +A  + A F  P+AA +   + +  +    +W
Sbjct: 132 QLGATIGQGVEEKAKVGHLNRQIGIASGAAAGLSAAFNAPIAATIFILEEVYHNFSPVIW 191

Query: 184 DRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWC 243
               A  +++    + +  FF     L + +   +          +  +    G +    
Sbjct: 192 ---LATFVSSLCSNMVSMQFFGLRPVLNVPYNHMLPNNLYWHLIALGILLGILGRLYQIV 248

Query: 244 LPRLHAMMHQMKN-PVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYF 302
           +  L+    ++     +   I  F+L I      P++L  G + +  ++ +  FS + + 
Sbjct: 249 ILHLNGWTARIPKLSPIAYPIIPFLLVIPIAWYFPITLGGGNELI-IILRSLPFSLALFV 307

Query: 303 LLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHE------HVPAVPAAITVSCAI 356
            L V++    +++  S   GG   P + +G  LG +          +P       +   +
Sbjct: 308 GLFVLRFVFSMISYGSQLPGGIFLPILTLGAILGAVYCALMVRLGLMPVRYLPNFIIYGM 367

Query: 357 LGIVLVVTRDGWLSLFMAAVVVPNTTLLPL 386
            G    +++  + ++ +   +V +   L  
Sbjct: 368 AGYFACISKAPFTAILLITEMVGSLAHLMP 397


>UniRef50_B8FFG6 Chloride channel core n=2 Tax=Desulfobacteraceae RepID=B8FFG6_DESAA
          Length = 604

 Score =  203 bits (516), Expect = 1e-50,   Method: Composition-based stats.
 Identities = 70/432 (16%), Positives = 143/432 (33%), Gaps = 27/432 (6%)

Query: 2   LHPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPG-------------- 47
           L P+    +      VAIG+ + L  I+   +           L G              
Sbjct: 13  LDPKGAYAMKWVARFVAIGVVAGLGSILFHFLCEAGMRYFLDALAGYRPPAAAGESHRMF 72

Query: 48  TLGIAQDSPLWIIGVLTLTGIAVGLVIR-FSQGHAGPD----PACEPLIGAPVPPSALPG 102
             G+ +     ++ +    GI  G ++  F+    G             G  +       
Sbjct: 73  EPGVKEPVRWMLLLLPAAGGIFSGWLVYTFAPESEGHGTDAAIDAYHNKGGFIRGRVPII 132

Query: 103 LIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFG 161
             +A  + L  G S G E PI  +       +  +L L    R           +G++F 
Sbjct: 133 KTLASAITLTTGGSGGREGPIAQIGAGFGSFLATKLKLSDRERRIMLAAGMGAGVGSIFR 192

Query: 162 TPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIA-HYGQMEM 220
            P+A AL  ++ L    ++   + +    ++A        L +          ++   + 
Sbjct: 193 APLAGALFAAEVLYRDPDIE-GEVVLPAGLSAVVAYCIFCLTYGWGSLFKAPVNFVFRDP 251

Query: 221 TDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSL 280
            ++L   I+A +  AAG V V     +     ++  P     + G +         P +L
Sbjct: 252 AELLPYTILALVVAAAGWVYVKSFYGVTGFFKRLALPNHFKPVLGGLCTGAIGFFFPQTL 311

Query: 281 FKGLDEMQQMVANQA-FSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLML 339
             G   +Q  ++     +     +LA  K+     +  SG  GG   P+V +G A+G ++
Sbjct: 312 AFGYGYVQWAISGDPRATIPFLLILAFGKILTTSFSIGSGGSGGVFGPSVVIGGAIGGVV 371

Query: 340 HEHVPAV----PAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAW 395
                 +         V   + G    V+     ++   + +  +  LL    +V   ++
Sbjct: 372 GMIFHQLGWVDQPGAFVIVGMAGFFTGVSNTPISTIIFVSEMTSSYHLLLPSLLVCTVSY 431

Query: 396 LLLAGKPMMMVN 407
           L+     + ++ 
Sbjct: 432 LVSRKWTIYVMQ 443


>UniRef50_A6CC67 Putative chloride channel n=2 Tax=Planctomycetaceae
           RepID=A6CC67_9PLAN
          Length = 622

 Score =  202 bits (515), Expect = 2e-50,   Method: Composition-based stats.
 Identities = 77/456 (16%), Positives = 144/456 (31%), Gaps = 47/456 (10%)

Query: 7   RTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIA-------------- 52
           +T     + +  IGI + L  IV   +  V+Q+     + G                   
Sbjct: 17  KTSGKWFVLSCLIGIVAGLGGIVFDVLIQVVQHNTLVAIAGFDHPQTVGEHSIYEDEEAR 76

Query: 53  -QDSPLWIIGVLTLTGIAVGLVIR-FSQGHAGPD----PACEPLIGAPVPPSALPGLIVA 106
              SP W++ V+T  G+  G+++   +    G                + P       +A
Sbjct: 77  KAFSPWWMLAVITAGGLVSGIIVYNIAPEAEGHGTDAAIDAFHNKRGLILPRVPIVKTIA 136

Query: 107 LILGLAGGVSLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVA 165
             L L  G S G E PI  +       +   L L   +R           IGA+F  P+A
Sbjct: 137 SALTLGTGGSAGREGPIAQIGAGFGSWVATVLKLSARDRRIMLAAGVGAGIGAIFRAPLA 196

Query: 166 AALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTT------GLFFHPHFSLPIAHYGQME 219
            AL  ++ +  +++    D +    M++              L F P F   + H     
Sbjct: 197 GALFAAEIMYSNADFE-SDVIVPAAMSSIIAYSVYCMSLPQELQFMPLFGDGLHHTVDSH 255

Query: 220 MTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPV- 278
             +++   I++ I   A M  V      +     +    +     G  L  +  IG    
Sbjct: 256 F-ELIPYTILSVILSLAAMFYVKTFYGTNRFFKSIPIKPMFKPAIGAFLTGIVGIGMYYL 314

Query: 279 ---------SLFKGLDEMQQMVANQA-FSTSDYFLLAVIKLAALVVAAASGFRGGRIFPA 328
                     +  G   +Q  + + A  S      +AV+K+    +   SG  GG   P+
Sbjct: 315 FNKDLQALTVMSTGYGILQDALTSAAQISIPLLLTVAVVKVFTTSLTIGSGGSGGVFGPS 374

Query: 329 VFVGVALGLMLHEHVPAV------PAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTT 382
           + +G  +G      +  +               + G           ++ M + +  N +
Sbjct: 375 MVIGGCVGTATGRILQDLWPEMVTQPEAYGLVGMAGFFAGAAHAPISTIIMVSEITGNYS 434

Query: 383 LLPLLCIVMLPAWLLLAGKPMMMVNRP-KQQPPHDN 417
           LL    +     ++L     +     P +   P   
Sbjct: 435 LLLPTMLSSTLCFVLCQKVHLYQKQYPSRLDSPAHR 470


>UniRef50_D2W1T3 Chloride channel ClC-3 n=1 Tax=Naegleria gruberi RepID=D2W1T3_NAEGR
          Length = 787

 Score =  202 bits (514), Expect = 2e-50,   Method: Composition-based stats.
 Identities = 56/470 (11%), Positives = 128/470 (27%), Gaps = 88/470 (18%)

Query: 13  SLPAVAIGIASSLILIVVMKIASVLQNL-------------------------------- 40
            +    IG    +   +V K    L                                   
Sbjct: 78  WIMTFLIGAWIGIFASIVDKGMEWLAGFKEGVCVNYFLATQTRCCVEVPVGIKCEDWKTW 137

Query: 41  --LWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRFSQGHAGP-DPACEPLIGAP--- 94
             ++         A D   +I   + +  ++   V   +   AG   P  + ++G     
Sbjct: 138 SEIFGIYETNGAYAFDYFAYIFIAVCMATLSAWFVKSLAPWAAGSGIPEVKTILGGFVIK 197

Query: 95  --VPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARL----LPRVNRMEWT 148
             +    L   I+ L+L +  G++LG E P++ V   +                 + E  
Sbjct: 198 GCLGIMTLIVKIIGLVLAVGSGLTLGKEGPMVHVGGCVGNVFSRIFSKYRNNEAKKREMI 257

Query: 149 ILASAGTIGALFGTPVAAALIFSQTLNGSS-EVPLWDRLFAPLMAAAAGALTTGLFFHPH 207
             + A  +   FGTP    L   + L+       L+   FA ++ A    +         
Sbjct: 258 SASCAAGVACAFGTPAGGTLFSLEELSSYFPPKTLFRTFFACVIGALTLQIINPRPSGKI 317

Query: 208 FSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQ--MKNPVLVLGIGG 265
               I+++   +  ++++   +  +    G +           + +       ++  IG 
Sbjct: 318 VLYSISYHVNWKWFELIAFIFLGIVGGLLGALFTKLNISFIKNVRKKYFGKWPILETIGL 377

Query: 266 FILGILGVIGGPVSLFKGLDEMQQMVAN-------------------QAFSTSDYFLLAV 306
            IL  +       S     D + ++  N                     ++     +  V
Sbjct: 378 TILTSVLCYWNEYSRMPMSDLIARLFENTCTENSSADSIFVELCDPTNFWAMGKLMISFV 437

Query: 307 IKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEH-------VPAVP------------ 347
           ++   L +        G + P++ +G   G ++           P  P            
Sbjct: 438 LRFILLSLTVGIKIPSGVLVPSLAIGACYGTLVGSIMKYVQLTFPDSPFFQECYAGGEGS 497

Query: 348 ---AAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPA 394
                +        ++  V R       +   +      L  + + ++ A
Sbjct: 498 CVVPGMYAVIGAATMLGGVCRITVSLAVIMFELTGGLEYLVPIMLSVMFA 547


>UniRef50_Q701W5 Putative chloride channel protein n=1 Tax=uncultured crenarchaeote
           RepID=Q701W5_9CREN
          Length = 648

 Score =  201 bits (513), Expect = 3e-50,   Method: Composition-based stats.
 Identities = 69/406 (16%), Positives = 127/406 (31%), Gaps = 32/406 (7%)

Query: 11  LLSLPAVAIGIASSLILIVVMKIASVLQNLLWQ--------------RLPGTLGIAQDSP 56
             ++  + IG+ S L++I   +   +  +                   L     +    P
Sbjct: 26  KWTVIGIIIGVLSGLLVITAYEAMRIFSSFFLSDVVRYIQPYPEDVANLSSEYSLYVLKP 85

Query: 57  LWIIGVLTLTGIAVGLVIRFSQGHAG-----PDPACEPLIGAPVPPSALPGLIVALILGL 111
             I  +L L G+ +GL+        G                 +          +  L +
Sbjct: 86  WLIPVILGLIGLVIGLLSMKLSTSLGQNGIDEISDEFHNKKNKLSIKNSSLKTFSSFLAI 145

Query: 112 AGGVSLGPEHPIMTVNIALAVAIGARLLPRVNR-MEWTILASAGTIGALFGTPVAAALIF 170
             G S G E  +      LA  IG                    TIG +   P   A+  
Sbjct: 146 GSGTSGGVEDSLAHTGSTLASIIGRIFKLDQEEIRIAIAAGMGSTIGGILRLPFGGAIFS 205

Query: 171 SQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAH--YGQMEMTDILSGAI 228
            + L     +     L+   +A+    + +G+       L I      +  +  I +  +
Sbjct: 206 LELLYRRDFI--IKSLYPAFLASITSYIVSGVVLDWPSFLYIPQEFITKTTLQSIAAYGV 263

Query: 229 VAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQ 288
           +AAI    G+  V  +         MK P+      G ++  +  IG P  L  G   +Q
Sbjct: 264 IAAIIGIVGIGYVKTVQIFQRHFENMKIPLYFKPALGGVIIGIFAIGFPEILGTGYGWLQ 323

Query: 289 QMVANQAFSTSDYFLLAVI--KLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAV 346
                       + +  VI  K+ A  V+ AS    G + P++ +G  +G  L     + 
Sbjct: 324 LAALGNHEVFPLWIMFPVIAMKIFATSVSNASRNTTGLLGPSLVIGGLIGSALITLFHSF 383

Query: 347 PAAITV------SCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPL 386
              + +        +I       TR    ++ +   +V + TLL  
Sbjct: 384 GIFLFIDTTSATLISIFAFFTASTRTPISAIVVGVEMVGSYTLLIP 429


>UniRef50_C6BS05 Chloride channel core n=1 Tax=Desulfovibrio salexigens DSM 2638
           RepID=C6BS05_DESAD
          Length = 582

 Score =  201 bits (513), Expect = 3e-50,   Method: Composition-based stats.
 Identities = 66/412 (16%), Positives = 142/412 (34%), Gaps = 28/412 (6%)

Query: 2   LHPRARTM-LLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWII 60
           LH RA +    L   A  IG  S+L  +V+ +    L  L                 W+ 
Sbjct: 17  LHKRAPSRNAKLIFAATVIGCCSALAAVVLNRALDYLSTLRMTNSQ---------HWWMF 67

Query: 61  GVLTLTGIAVGLVIRF-----SQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGV 115
            +  +      ++ +           G   A   L    + P ++   ++  +L +A G 
Sbjct: 68  MLPAVGATLAVILSKNIFKESGGHGVGEVIAKVGLKQGILRPISIISSLLTSLLTIASGG 127

Query: 116 SLGPEHPIMTVNIALAVAIGARLL-PRVNRMEWTILASAGTIGALFGTPVAAALIFSQTL 174
           S GPE P++    A+   +         +RM      +AG+I A+F  PV   +   + +
Sbjct: 128 SAGPEAPVVVSGSAMGSNLSRLFKMSGQSRMTLIGCGAAGSISAIFNAPVTGMIFAVEII 187

Query: 175 NGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAI 234
            G         L    +++     T+ L            +  M +TD+ +  ++A +  
Sbjct: 188 LGEWTPYH---LIPIAISSVVATQTSRLLEGNVIPFN-DQFPPMGITDLGTSILLAVLTA 243

Query: 235 AAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQ 294
              ++ V  + ++ +    + N   +    G +   +  I  P++L +G   ++  +   
Sbjct: 244 LVSVLFVRLIRQVGSACSSLTNKPWIKAACGGLAVGIIGIFFPLALGEGYTSIKMAIHGT 303

Query: 295 AFSTSDYFLLA-VIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPA----- 348
                       ++++    +   SG  GG   P + +G   G   +  +  +       
Sbjct: 304 LPDGIALIAFMGMLRIVTTSLTLGSGGLGGIFAPCLVIGSLFGAFYYRVISQIIPQNILT 363

Query: 349 --AITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL 398
                    + G+V  V +    S+F+   +      +  + IV   + +L 
Sbjct: 364 GEGSYALLGMAGVVSGVMQAPLTSVFLVLEITHGYQAVMHIMIVTFLSSMLT 415


>UniRef50_D2RLN6 Cl-channel voltage-gated family protein n=1 Tax=Acidaminococcus
           fermentans DSM 20731 RepID=D2RLN6_ACIFE
          Length = 526

 Score =  201 bits (513), Expect = 3e-50,   Method: Composition-based stats.
 Identities = 58/399 (14%), Positives = 132/399 (33%), Gaps = 17/399 (4%)

Query: 10  LLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIA 69
           L L+   + +GI + L + V+      +     + +     +     L  +G L L  + 
Sbjct: 21  LKLAFEGILVGITTGLCITVLRLCLGFVARNRAKMVDFLQNVPPAYTLLWVGALLLIAMV 80

Query: 70  VGLVIRFSQGHAGP-DPACEPLIGAPVP----PSALPGLIVALILGLAGGVSLGPEHPIM 124
           +  ++R++    G   P    ++            +   ++   LG+  G+S+G E P +
Sbjct: 81  IAALVRWAPIAGGSGIPQVRGIVLGLEKSTHWARVILVKLLDTSLGIGAGLSMGREGPSV 140

Query: 125 TVNIALAVAIGARLLPRV-NRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLW 183
            +       +G  L      +       +   + A F  P+A  +   + ++ +      
Sbjct: 141 QIGAMTGQGVGNALNNTNLEKRALISSGAGAGLAAAFNAPMAGVMFTMEAIHKNLSA--- 197

Query: 184 DRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWC 243
             +   LMA     +     F     L I     + +  +    ++  ++   G+     
Sbjct: 198 IVMAPTLMACMTTTVLVHWVFGVETVLTIPKMPILPVELLPQVIVLGLVSGLIGVAFNKG 257

Query: 244 LPRLHAMMH-QMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYF 302
              +       +     +      +L I      P  L  G + ++ MV  +  +     
Sbjct: 258 SLNIGRFYSLPVFRKPWMKIAFPLLLTIPLTYLLPQILGAGDNIIEAMVDLEG-TLGMVL 316

Query: 303 LLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHE------HVPAVPAAITVSCAI 356
           ++ + K    + +  SG  GG + P + +G  +G +          +P       V   +
Sbjct: 317 VILLGKFFFTIFSTGSGAPGGSLQPMLVLGSLVGSLYGNLLVQLGLLPEAYRLNMVVFGM 376

Query: 357 LGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAW 395
            G+     R    ++ +   +      L  L IV L A+
Sbjct: 377 AGLFAGSVRAPVTAILLLLEMTGRFYHLVPLGIVTLFAY 415


>UniRef50_A5FBK4 Cl-channel, voltage-gated family protein n=4 Tax=Flavobacteriales
           RepID=A5FBK4_FLAJ1
          Length = 598

 Score =  201 bits (513), Expect = 3e-50,   Method: Composition-based stats.
 Identities = 66/413 (15%), Positives = 140/413 (33%), Gaps = 28/413 (6%)

Query: 12  LSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAV- 70
           + L +V IGI ++  +I +   A  + +     +   + ++  + +  +  + LT + V 
Sbjct: 29  IFLSSVLIGIIAAFAVIFLKAFAHWVFSFA-AYINAIVKLSFINSILPLIGILLTVLVVN 87

Query: 71  GLVIRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIAL 130
            ++    +              + +P   +   I+   L +  G S G E PI+    A 
Sbjct: 88  RILGGSLEKGTSQILYIVARKASIIPKKQMYAQIMTSSLTVGLGGSAGLESPIVITGAAF 147

Query: 131 AVAIGARLLPRVNRMEWTI-LASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAP 189
                 +           I    A  I A F  P+A  L   + L     +         
Sbjct: 148 GSNFAQQFKLSYQERTLLIGCGVAAGIAAAFNAPIAGVLFAVEVLLVDVTIA---AFTPI 204

Query: 190 LMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHA 249
           ++AAA GAL + +  + +  L        +  +I    ++        +       +   
Sbjct: 205 MIAAATGALVSAVVLNENILLVFREKQTFDYHNIPFYVLLGLFTGLTAVFYARKFLKTEH 264

Query: 250 MMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQA-----------FST 298
               +K       + G  +  + +   P    +G + ++ +                +S 
Sbjct: 265 FFAHLKFGPYKKALIGGAVLGILIFVFPTLFGEGYESIKILADKNPGALLKNTLFEQYSD 324

Query: 299 SDYFLLA------VIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPA-----VP 347
           S + LLA       +K  A  +   SG  GG   P++F+G   G    + +       +P
Sbjct: 325 SSWILLAFVGFSMFLKAFASGITLGSGGNGGNFAPSLFLGSYAGYFFSKLLNLAGLTDLP 384

Query: 348 AAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAG 400
            +      + GI+  +      ++F+ A +     L+  L IV   ++ +  G
Sbjct: 385 ISNFTLVGMAGILSGLFHAPLTAIFLIAEITGGYDLMIPLMIVASVSFAVSKG 437


>UniRef50_C8WAP8 Chloride channel core n=2 Tax=Atopobium RepID=C8WAP8_ATOPD
          Length = 528

 Score =  201 bits (512), Expect = 4e-50,   Method: Composition-based stats.
 Identities = 59/382 (15%), Positives = 116/382 (30%), Gaps = 14/382 (3%)

Query: 28  IVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRFSQGHAGPDPAC 87
            +     S  +  +        G      LW   +L L      L+           P  
Sbjct: 40  TLYRLCLSFAEVQMRSITQSIAGNWPYMALWFGILLILMIAVCLLMKFEPYTSGSGIPQT 99

Query: 88  EPLIGAPVP---PSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARL-LPRVN 143
              +           LP   +  +L   GG+S+G E P + +      A+   L   R  
Sbjct: 100 NAEVMGSADMPWYRVLPVKFIQGVLVAFGGLSMGREGPSVQLGAVSGKAVSKLLKRKRGE 159

Query: 144 RMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLF 203
                   +A  + A F  P+   L   + +      PL   + + + A+          
Sbjct: 160 ERLLVTCGAAAGMSAAFHAPLTGTLFAIEEIQKEFHAPL---IISAMTASVGADFLVSNV 216

Query: 204 FHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLV-LG 262
                 L + +   +   D      V  I    G +    +     +  ++   V     
Sbjct: 217 LGMKPVLQLPYVAPLPHVDYAFVLFVGVICGLLGALHNKGMFFAQRLYKKITKFVPFSRL 276

Query: 263 IGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRG 322
           I  F+L  +     P  L  G   ++++    A +     +L + K        A+G  G
Sbjct: 277 IIPFMLAGIMAFTWPDLLCGGDAIIEKIKEPAALTELMVIVLLLGKYFFTTTCFAAGTPG 336

Query: 323 GRIFPAVFVGVALGLMLHEH------VPAVPAAITVSCAILGIVLVVTRDGWLSLFMAAV 376
           G +FP V +G  +G +          +P   A   ++  + GI     R     + +   
Sbjct: 337 GTLFPMVVMGTLVGTLFALVATHIFGIPMAYAPNFIAMGVAGIFAGAVRAPVTGVVLIFE 396

Query: 377 VVPNTTLLPLLCIVMLPAWLLL 398
           +  +   L  +  V + +++  
Sbjct: 397 LTGSLEALMAMSAVAIVSYVTA 418


>UniRef50_C2KWR2 Chloride carrier/channel (ClC) family transporter n=1
           Tax=Oribacterium sinus F0268 RepID=C2KWR2_9FIRM
          Length = 442

 Score =  201 bits (511), Expect = 5e-50,   Method: Composition-based stats.
 Identities = 63/408 (15%), Positives = 132/408 (32%), Gaps = 23/408 (5%)

Query: 7   RTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLT 66
           +  L   L  +  G     I         +      +               ++  L   
Sbjct: 36  KNGLKWILLGILTGAVVGSISAFFAHGIVLASAFRVKHPQ------------LLFALPFA 83

Query: 67  GIAVGLVIRFSQ---GHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPI 123
           G+ +                        G  +P    P +I + +L    G S+G E   
Sbjct: 84  GLLLVFAYSILSDKNKKGTNLVIESVRRGEKLPVEMAPLIIFSTVLSHLFGASVGREGAA 143

Query: 124 MTVNIALAVAIGARLLPRV-NRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPL 182
           + V  +L  +IG  L      +    +   +     LFGTP+AAA+   +          
Sbjct: 144 LQVGGSLGSSIGRVLHLSEKEQRRIMMCGMSAAFSGLFGTPIAAAIFAIELCT--VGSIY 201

Query: 183 WDRLFAPLMAAAAGALTTGLFFH-PHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAV 241
           +  L    ++A           H     L ++   +M+ +  L   ++A  A    +V V
Sbjct: 202 YTALLPCTVSALTAHFFAEKVIHAEEPDLALSLMAEMDWSSALYTLLLAIAAALVSIVFV 261

Query: 242 WCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDY 301
            C  +   +  +      +       + +L  +    +++ G   +Q +        +  
Sbjct: 262 SCAHKAKDLFSKYFPNPYLRIFVSGAIVLLATLALNTNIYNGTG-IQLITQTIHEPGTKI 320

Query: 302 FLL-AVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIV 360
           FL    +K+    V+   GF+GG I P++F+G  LG  L   +P  P ++  +  +  + 
Sbjct: 321 FLFAFFLKILFTSVSLGGGFQGGEIVPSLFIGATLGNALSRFLPLDP-SLCAALGMTALF 379

Query: 361 LVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNR 408
             VT     +L ++  +           + +  ++L      +    +
Sbjct: 380 CGVTNCPLTALLISFELFGFQAS-SYFLLAIAISYLFSGNYGLYHSQK 426


>UniRef50_Q1ZH67 Chloride channel protein n=1 Tax=Psychromonas sp. CNPT3
           RepID=Q1ZH67_9GAMM
          Length = 470

 Score =  201 bits (511), Expect = 5e-50,   Method: Composition-based stats.
 Identities = 61/423 (14%), Positives = 135/423 (31%), Gaps = 22/423 (5%)

Query: 7   RTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLW-IIGVLTL 65
           ++ LLL L AV IGI +  +     +  + +     + +           L  I     +
Sbjct: 25  KSALLLWL-AVLIGILAGALSAFFDRCINWIGAFRVELIEQYSSPGLPLWLVAIPISSVM 83

Query: 66  TGIAVGLVIRFSQGHAGP-DPACEPLIGAPVPP---SALPGLIVALILGLAGGVSLGPEH 121
            G+A  +  RF+    G   P  E  +    P      LP      +L L  G++LG E 
Sbjct: 84  VGLAFYITHRFAPESGGSGIPEIEGAMEGMRPVRWKRVLPVKFFGGLLALGSGMALGREG 143

Query: 122 PIMTVNIALAVAIGARLLPRV-NRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEV 180
           P + +   +   I         +        +A  + A F  P+A  +   + +      
Sbjct: 144 PSVQLGANIGRMISDTFKMDKLDAQALLASGAAAGLAAAFNAPLAGIMFVIEEMRSQFNY 203

Query: 181 PLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVA 240
            L     +  ++A    +           + +  Y   ++  +    ++       G++ 
Sbjct: 204 SL-TSTKSVFISAVMATIVMRFMTDQQAVVTVTQYSHPDLMSLWLYLLLGFCFGVLGVLF 262

Query: 241 VWCLPRLHAMMHQMKNPVLVLGIGGFI----LGILGVIGGPVSLFKGLDEMQQMVANQAF 296
              +     M   +        +   +    +     +  P   F GL+ + Q V    F
Sbjct: 263 NKMILATQDMYLFIHKNQRWRFVCVGLFLGGVFGALSVLSPHIAFSGLELIPQ-VEGGEF 321

Query: 297 STSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAI------ 350
                 ++ + ++   +++  SG  GG   P + +G   G++           +      
Sbjct: 322 FAGGLLVIFLFRILTTLLSFGSGAPGGVFAPTLALGTLFGMLFGLGAHEFFPELVSMPGT 381

Query: 351 TVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL---AGKPMMMVN 407
                + G+     R     + +   +  N  ++  L +  L A ++     G+P+    
Sbjct: 382 FAIAGMGGLFAATVRAPITGILLVIEMTSNYQMILPLIVTCLGATMVAQALGGRPIYTQL 441

Query: 408 RPK 410
             +
Sbjct: 442 LER 444


>UniRef50_C1MEP8 Voltage-gated chloride channel family protein n=4 Tax=Bacteria
           RepID=C1MEP8_9ENTR
          Length = 457

 Score =  200 bits (510), Expect = 7e-50,   Method: Composition-based stats.
 Identities = 79/402 (19%), Positives = 147/402 (36%), Gaps = 24/402 (5%)

Query: 12  LSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVG 71
             + A  I + +     V +                     ++S  W+I +L L G+ VG
Sbjct: 19  WLVTASLIALLAGTASAVFLLSLDNATAW------------RESHSWMIWLLPLAGLLVG 66

Query: 72  LVIRF--SQGHAGPDPACEPLIGAP--VPPSALPGLIVALILGLAGGVSLGPEHPIMTVN 127
           LV  +     +AG +   + +      VP   +P ++   ++    G S+G E   + + 
Sbjct: 67  LVYSWYGEPVNAGNNLIIDEIHDPRKVVPIRMVPLVLGGTLMSHLFGASVGREGTAVQMG 126

Query: 128 IALAVAIGARLLPRVN-RMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRL 186
            ALA  +      + + R    +   +    ++FGTP+A A+   + L  +     +D L
Sbjct: 127 GALADQLTHMFKVKKDARRILLMAGMSAGFSSVFGTPMAGAIFGMEVL--AIGRIRYDAL 184

Query: 187 FAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPR 246
           F  L+AA         +   H    I       +   LS  I  A+   AGMV      +
Sbjct: 185 FPCLVAAVLADQVCLAWGVHHTHYRIDFIPAFTIWSFLSVVIAGAVFGLAGMVFSVATGK 244

Query: 247 LHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAV 306
              ++ +      +    G IL    V       + GL   + +   +AF    Y +  +
Sbjct: 245 ASGIVKRYIKYAPLRPFFGGILIAAAVWFIGTDRYIGLGIPEIV---RAFKEPLYPMDFM 301

Query: 307 IKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLVVTRD 366
            K++  +V+ A+GF+GG + P  ++G  LG  L   +  +P A       + +       
Sbjct: 302 GKMSFTIVSLATGFKGGEVTPLFYIGATLGNALAPLLH-MPFAFMAGIGFVAVFAGAANT 360

Query: 367 GWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNR 408
              + FMA  +   T +     +    A+L      +    R
Sbjct: 361 PLATTFMAMELFG-TEMAVFSAVGCFTAYLFSGHTGIYHAQR 401



 Score = 42.5 bits (99), Expect = 0.032,   Method: Composition-based stats.
 Identities = 32/215 (14%), Positives = 57/215 (26%), Gaps = 17/215 (7%)

Query: 3   HPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGV 62
           H R   +   ++ +    + +  +  +   + SV        +   +  A   PL     
Sbjct: 207 HYRIDFIPAFTIWSFLSVVIAGAVFGLAGMVFSVATGKASGIVKRYIKYA---PLRPFFG 263

Query: 63  LTLTGIAVGLVIRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHP 122
             L   AV  +    +      P        P+ P    G +   I+ LA G   G   P
Sbjct: 264 GILIAAAVWFIGT-DRYIGLGIPEIVRAFKEPLYPMDFMGKMSFTIVSLATGFKGGEVTP 322

Query: 123 IMTVNIALAVAIGARLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPL 182
           +  +   L  A+   L           +           TP+A   +  +          
Sbjct: 323 LFYIGATLGNALAPLLHMPFAF--MAGIGFVAVFAGAANTPLATTFMAMELFGTEM---- 376

Query: 183 WDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQ 217
                   + +A G  T  LF            G 
Sbjct: 377 -------AVFSAVGCFTAYLFSGHTGIYHAQRVGH 404


>UniRef50_D1BPZ0 Chloride channel core n=3 Tax=Veillonella RepID=D1BPZ0_VEIPT
          Length = 514

 Score =  200 bits (510), Expect = 7e-50,   Method: Composition-based stats.
 Identities = 58/397 (14%), Positives = 129/397 (32%), Gaps = 16/397 (4%)

Query: 12  LSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVG 71
           L      +G+ +         +    +++ W  + G     + +  W++ ++    I   
Sbjct: 26  LIAKGALVGVIAGFFGASYRYLILESEHIRWHLMEGIT--MEWAIGWLVAMVIFAFIVDR 83

Query: 72  LVIRFSQGHAGPDPACEPLIGAPV---PPSALPGLIVALILGLAGGVSLGPEHPIMTVNI 128
           L+           P  E  +       P   L   ++  +L    G S+G E P + +  
Sbjct: 84  LLAWAPLSGGSGIPQIEGEMLGLFDMKPYRTLVSKMIGGVLTGFAGFSVGREGPAVQIGG 143

Query: 129 ALAVAIGARLLPR-VNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLF 187
           +    +   +      +   T   +   + A F  PV+ A+   + ++ S        + 
Sbjct: 144 SAGKIVSYWMNSGLREQRILTSAGAGAGLTAAFSAPVSGAMFVFEEVHKSF---YPYLVV 200

Query: 188 APLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRL 247
              +A       T   F    +L       + +       +V  I    G++    +   
Sbjct: 201 PTFVATLISNYITVSIFGLTPALGFTVTSGVPLEYFPILLMVGVIMGLCGVLFCRMIFAF 260

Query: 248 HAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVI 307
                 +K    +  +  F+          + L  G D + Q+   Q+        + + 
Sbjct: 261 KRFFDWLKCSRFLKLVLTFVAVAAIGFDSQLLLGGGNDLVGQLAF-QSHGVLLLGGIVLG 319

Query: 308 KLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAV------PAAITVSCAILGIVL 361
           K+        SG +GG   P + +G A G      +  +           V CA+ G++ 
Sbjct: 320 KILLTTFCYGSGAQGGIFLPMLVIGAATGAFCESLLSTLGLISPDFVPQFVICAMGGMLA 379

Query: 362 VVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL 398
              R   L++ +   +  + + +  + IV L A+L+ 
Sbjct: 380 AAMRTPILAILLVLEMTDSFSNIYAIGIVTLVAYLVA 416



 Score = 42.1 bits (98), Expect = 0.039,   Method: Composition-based stats.
 Identities = 27/204 (13%), Positives = 60/204 (29%), Gaps = 21/204 (10%)

Query: 10  LLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIA 69
           L      + +G+   L  ++  ++    +              + S    + +  +   A
Sbjct: 233 LEYFPILLMVGVIMGLCGVLFCRMIFAFKRFF--------DWLKCSRFLKLVLTFVAVAA 284

Query: 70  VGLVIRFSQGHAGPDPACEPL--IGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVN 127
           +G   +   G              G  +    + G I+        G   G   P++ + 
Sbjct: 285 IGFDSQLLLGGGNDLVGQLAFQSHGVLLLGGIVLGKILLTTFCYGSGAQGGIFLPMLVIG 344

Query: 128 IALAVAIGAR-----LLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPL 182
            A      +      L+      ++ I A  G + A   TP+ A L+  +  +       
Sbjct: 345 AATGAFCESLLSTLGLISPDFVPQFVICAMGGMLAAAMRTPILAILLVLEMTDS------ 398

Query: 183 WDRLFAPLMAAAAGALTTGLFFHP 206
           +  ++A  +      L   L   P
Sbjct: 399 FSNIYAIGIVTLVAYLVAELLKEP 422


>UniRef50_B5XVU7 Chloride transporter, chloride channel (ClC) family n=18
           Tax=Bacteria RepID=B5XVU7_KLEP3
          Length = 411

 Score =  200 bits (508), Expect = 1e-49,   Method: Composition-based stats.
 Identities = 316/408 (77%), Positives = 364/408 (89%)

Query: 1   MLHPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWII 60
           MLHPRARTML+LS+PA+ IGIA SLILI  MK+A++LQ +LW  LP  LGI+ DSPLWII
Sbjct: 1   MLHPRARTMLILSVPAILIGIACSLILIGAMKVAALLQRVLWSNLPTQLGISADSPLWII 60

Query: 61  GVLTLTGIAVGLVIRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPE 120
            +LT TGIAVGLV+R+S GHAGPDPA E LIGAP+   ALPGL+ ALILGLAGGVSLGPE
Sbjct: 61  AMLTATGIAVGLVVRYSPGHAGPDPATESLIGAPIATGALPGLLAALILGLAGGVSLGPE 120

Query: 121 HPIMTVNIALAVAIGARLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEV 180
           HPIM VNIALAVA+G+RL PRV+ ++WTILA++GTIGALFGTPVAAALIFSQTLN S+E 
Sbjct: 121 HPIMVVNIALAVAVGSRLFPRVSSLDWTILAASGTIGALFGTPVAAALIFSQTLNSSNES 180

Query: 181 PLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVA 240
           PLWDRLFAPL+AAAAGALTTGLFFHPHF+LPI HYGQM   DI+SG IVA IAIA GMVA
Sbjct: 181 PLWDRLFAPLLAAAAGALTTGLFFHPHFTLPIPHYGQMHFVDIISGMIVALIAIAVGMVA 240

Query: 241 VWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSD 300
           VWCLPRLHA+MH++++P+L LGIGG +LGILG IGGP++LFKGLDEMQQ+  +Q  + +D
Sbjct: 241 VWCLPRLHALMHRLRHPILTLGIGGLLLGILGTIGGPLTLFKGLDEMQQLAFSQTLTAAD 300

Query: 301 YFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIV 360
           + L+A++KLAALV+A+ASGFRGGRIFPAVFVGVALGLMLH HV AVPAAITVSCAILG+V
Sbjct: 301 FLLIALVKLAALVLASASGFRGGRIFPAVFVGVALGLMLHAHVDAVPAAITVSCAILGMV 360

Query: 361 LVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNR 408
           LVVTRDGWLSLFMAAVVVP+TTLLPLLCIVMLPAWLLLAG+P+M+  R
Sbjct: 361 LVVTRDGWLSLFMAAVVVPDTTLLPLLCIVMLPAWLLLAGRPLMIAKR 408


>UniRef50_Q1QSB4 Cl-channel, voltage gated n=1 Tax=Chromohalobacter salexigens DSM
           3043 RepID=Q1QSB4_CHRSD
          Length = 585

 Score =  199 bits (507), Expect = 1e-49,   Method: Composition-based stats.
 Identities = 61/401 (15%), Positives = 130/401 (32%), Gaps = 18/401 (4%)

Query: 11  LLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAV 70
            L +  V  G+ +  +++    +  +                   P+ ++  L   G+  
Sbjct: 30  QLCVLGVLSGVLTGGLMVGFRGLLELGALAFMPGGDPEAFERLAGPVRVVLPLMAVGLIG 89

Query: 71  GLVIRFSQGHA----GPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTV 126
             + R   G      G            +P           ++ L GG+S G E P + +
Sbjct: 90  VWLWRMPNGAGKIGIGHVIERLTYHQGKMPLRNWMTQWWVGLVALLGGLSAGREGPAIHL 149

Query: 127 NIALAVAIGARLLPRVNR-MEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDR 185
             A +  IG  +    N         +A  I A F TP+A  +   + +     +     
Sbjct: 150 GAAASSWIGQTMRLPHNSLRVLVGCGTAAGIAASFNTPIAGVIFAMEVVMMEYTIT---G 206

Query: 186 LFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLP 245
               ++A+  GA+ + L +    +  +       + D+   A+ A +        V    
Sbjct: 207 FMPVILASTTGAVVSQLVYGSQPAFSVPSVQLASLFDLPWIAVTALLIGLVAGAFVRL-- 264

Query: 246 RLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLA 305
                  Q + PV    +   +         P     G D +++M+  +  +     ++A
Sbjct: 265 -AKPATWQTRWPVWGRFLAVGLAVGAVAWWYPQVQGMGYDSLERMLVGEP-ALDVLIVVA 322

Query: 306 VIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAI------TVSCAILGI 359
           + KLA   +A A G     I P +  G A G +       +   +           +  +
Sbjct: 323 LGKLALTALAIAFGVPVSIIGPILVAGAAFGTLCGLLWATLLPGLASSPVVFSLLGMAAM 382

Query: 360 VLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAG 400
           +  V +    +L     +  N+++L    + ++ A L+   
Sbjct: 383 MGAVLQAPLAALMALLELTHNSSILLPGMLAVVIAVLVSRQ 423


>UniRef50_C6HUP8 Putative Cl-channel, voltage gated n=1 Tax=Leptospirillum
           ferrodiazotrophum RepID=C6HUP8_9BACT
          Length = 572

 Score =  199 bits (506), Expect = 2e-49,   Method: Composition-based stats.
 Identities = 57/424 (13%), Positives = 135/424 (31%), Gaps = 26/424 (6%)

Query: 5   RARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLT 64
           R          +V IG+ +  ++ ++ ++   L  L          +       ++ ++ 
Sbjct: 20  RLNIFWRTLFISVLIGVTTGFLVYLIERVVYRLLFLTLYNTAFKNHL-------VVILIP 72

Query: 65  LTGIAVG---LVIRFSQGHAGPDPACEPLI--GAPVPPSALPGLIVALILGLAGGVSLGP 119
           + G+ V    L         G +   +        +P       I A I  L  G S G 
Sbjct: 73  MAGVLVARYILASGRVDNAGGTEEIIKSYHEYRGKLPLRNALFKIPAYISTLGFGGSAGL 132

Query: 120 EHPIMTVNIALAVAIGARLLPR----VNRMEWTILASAGTIGALFGTPVAAALIFSQTLN 175
           E     +   ++  +             +    +  +A  + A+F  P   A+   Q   
Sbjct: 133 EGASTYIGGVVSSLVDRTFSWLRIPYEEQRVMLLAGAAAGLSAMFKAPFTGAIFVLQVPY 192

Query: 176 GSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIA 235
            S   P  + L   L+++ +  +             +A   Q    D LS  ++  +   
Sbjct: 193 RSDIAP--NALVPTLISSVSSYIVMVSLVGTAPLFQLAAKAQFHFKDFLSVIVIGVVCGF 250

Query: 236 AGMVAVWCLPRLHAMMHQ-MKNPVLVLGIGGFILGILGVIGGPVS------LFKGLDEMQ 288
              + +    +      +  ++ + +  I G ++  L       +      L  G   +Q
Sbjct: 251 LTALFIRIYRQTKRWFSEGSRHRIGLRPILGALILGLTGYVATRAWGEALPLGPGYIFIQ 310

Query: 289 QMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPA 348
            ++            L  +K  A++   ++G  GG  FP + +G A G ++ +     P 
Sbjct: 311 HLLTGN-VPIDMALELFFLKAIAVIFTFSAGGIGGSFFPLLSLGAATGSVVAQIAGLEPY 369

Query: 349 AITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNR 408
              V   +   +    +    ++   A    ++  L    I  + ++++     +    R
Sbjct: 370 DFGVVMGMSAFLAAGYKTPLAAVVFIAEATHSSGYLIPGLIGTVVSYVVSGSTSISTHQR 429

Query: 409 PKQQ 412
            ++ 
Sbjct: 430 DRED 433


>UniRef50_C1TRX3 Chloride channel protein EriC n=3 Tax=Synergistaceae
           RepID=C1TRX3_9BACT
          Length = 480

 Score =  198 bits (505), Expect = 2e-49,   Method: Composition-based stats.
 Identities = 57/401 (14%), Positives = 128/401 (31%), Gaps = 19/401 (4%)

Query: 11  LLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAV 70
              L AV  G     +    +       +        T  +      +++ +  +    +
Sbjct: 26  KWFLLAVLAGAVVGSVTTFFVNSLEWAISW-------TAKLPPTFLWYMLPLGIVASTLI 78

Query: 71  GLVIRFSQGHAGP--DPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNI 128
                      G              +    +P  ++  ++ +A G S G E P   +  
Sbjct: 79  IKCFAPDARGHGTEKVIEAIHEHSGKISVKVIPIKLITTVITVAAGGSAGKEGPAAQIGA 138

Query: 129 ALAVAIGARLL-PRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLF 187
            L  ++ + L    ++R +  I   +    A+FGTPVA A+   + L        +D LF
Sbjct: 139 GLTSSLASLLRFSDLDRKKLVICGISAGFAAVFGTPVAGAIFGLEVL--YIGQVFYDVLF 196

Query: 188 APLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRL 247
              ++     L        +   P+     M     L   +  A       + +  +   
Sbjct: 197 PSFISGVVSHLVATSLGMSYGYYPLCDIPAMSGGIFLWMVVAGAFFGFVSFLHIEIMSFF 256

Query: 248 HAMMHQMKNPVLVLGIGGFILGI-LGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAV 306
             +  +++  ++V  I G +L + L    G      G D + + +  +        L  +
Sbjct: 257 ERVFSKVRGGLVVKAILGAVLMLFLAQTVGGEYFGLGTDVIDKALHGEKLPG----LAFL 312

Query: 307 IKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLVVTRD 366
            K     +  + G  GG + P  F+G   G+        +  A+      + ++      
Sbjct: 313 WKSLFTAITLSCGGSGGVVTPIFFIGATAGVTFASFF-GLNGALFGPIGFVAVLAGCANA 371

Query: 367 GWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVN 407
              +  MA  +  + ++     I  + ++LL+  + +    
Sbjct: 372 PISASIMAVELFGS-SVASFAAIACITSFLLVGHRSVYPSQ 411


>UniRef50_Q15YG3 Cl-channel, voltage gated n=4 Tax=Alteromonadales
           RepID=Q15YG3_PSEA6
          Length = 559

 Score =  198 bits (503), Expect = 4e-49,   Method: Composition-based stats.
 Identities = 66/422 (15%), Positives = 140/422 (33%), Gaps = 21/422 (4%)

Query: 7   RTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLT 66
           RT + L +  +  G+ ++ ++I+       LQ +    +     ++      +  +  + 
Sbjct: 14  RTSIQLCVLGIIGGVCAASVIILFRLSVEWLQLIYLDEVNNFTTLSTLERAIMPVIGVVL 73

Query: 67  GIAVGLVIRFSQGHAGPDPACEPLIG---APVPPSALPGLIVALILGLAGGVSLGPEHPI 123
            + V  +  F     G  P     +      +P              LA G S+G E P 
Sbjct: 74  ILCVAYLTGFKHYRMG-IPFVIHRVKKRFGHIPFRTTVNQFFGGAFALASGFSVGREGPS 132

Query: 124 MTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPL 182
           + +  A +   G  L LP  +    +    A  I A F TP AA +   + +    ++  
Sbjct: 133 VHLGAAGSSFFGQWLKLPDNSIRILSGCGIAAGISASFNTPFAAVIFVMEVVLREYKI-- 190

Query: 183 WDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVW 242
                  ++AAA G + T   F     L    + +      L   +   +  A   +   
Sbjct: 191 -HIFIPIMLAAACGTVMTRAVFGQAQELDFIEFFEFSRWIYLYLILFGILLGALATLFNN 249

Query: 243 CLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYF 302
            L ++  +  +    ++   +   ++        P +L      +  MV  Q        
Sbjct: 250 ALMKVMHIFQRFN--MIKRLLIAALITGAVGYILPQALGAHFFSVHDMVL-QQQDVVLLV 306

Query: 303 LLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAV------PAAITVSCAI 356
            +   K    ++A   G  GG + P   +G+  G +L   +          +       +
Sbjct: 307 AVLCAKFFITIIAIGLGVPGGIMGPVFVLGMLSGALLAAPLGLAVDNMEQLSGSFALLGM 366

Query: 357 LGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWL----LLAGKPMMMVNRPKQQ 412
            G++  V      +L     +  +  L+    +V++PA++     L    + +     Q+
Sbjct: 367 AGLMTSVVHAPLAALSAVMELSYSPELILPAILVIVPAYVTSTQFLGNSSIFIRQLDYQK 426

Query: 413 PP 414
            P
Sbjct: 427 LP 428


>UniRef50_D1CB35 Chloride channel core n=6 Tax=Bacteria RepID=D1CB35_THET1
          Length = 606

 Score =  197 bits (501), Expect = 7e-49,   Method: Composition-based stats.
 Identities = 64/417 (15%), Positives = 155/417 (37%), Gaps = 17/417 (4%)

Query: 8   TMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQ---DSPLWIIGVLT 64
            ++ +S  A+ +GI  + + ++++ +     +L + +      ++       L ++ V  
Sbjct: 31  RLIYISALAIIVGIVGAFLALILLYLIHFFTSLFFFQRISFQDVSPSRNHLGLAVLFVPV 90

Query: 65  LTGIAVGLVIRFS-----QGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGP 119
           + GI VGL+ R+                  + G+ V P       V+  + +  G   G 
Sbjct: 91  IGGIIVGLMARYGSEKIRGHGIPEAIEAILINGSKVEPRLAILKPVSSAITIGSGGPFGA 150

Query: 120 EHPIMTVNIALAVAIGARLL-PRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSS 178
           E PI+    A    I   L      R    +  +A  + A+FG P+AA  +  + L    
Sbjct: 151 EGPIIMTGGAFGSLIAQLLRLSSSERKTLLVAGAAAGMAAVFGAPLAAIALAVEVLLFEW 210

Query: 179 EVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQME-MTDILSGAIVAAIAIAAG 237
                  L    +++A                P   +     +  ++   I   +A    
Sbjct: 211 RP---RSLIPVAISSAIAGALRYYLLGTPPIFPTPTHTFYPTLMVLVDCFITGLVAGLLS 267

Query: 238 MVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFS 297
           ++  W +  +  +  ++    +     G +   +G +  P +L  G D +  M+  Q  +
Sbjct: 268 LILTWMVYTVEDIFRKLPVHWMWWPAIGGVFVGIGGLIYPRALGVGYDVIADMLRGQN-T 326

Query: 298 TSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAIL 357
                 + ++K A   +A  SG  GG + P + +G ++G++     P++        ++ 
Sbjct: 327 WQLILGILLVKSAIWAIALGSGTSGGVLAPILMIGGSIGIIESHIFPSMGEGFWPMLSMS 386

Query: 358 GIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAW---LLLAGKPMMMVNRPKQ 411
            ++    R    ++  A  +  +   +  L +V++ ++   +L   + ++     ++
Sbjct: 387 AVLGGAMRAPLTAIIFALELTHDIHSVIPLILVVIVSYGFTVLTMRRSILTEKLDRR 443



 Score = 41.7 bits (97), Expect = 0.056,   Method: Composition-based stats.
 Identities = 25/230 (10%), Positives = 63/230 (27%), Gaps = 35/230 (15%)

Query: 1   MLHPRARTMLLLSLPAVAIG--------------------------IASSLILIVVMKIA 34
           +   R R+++ +++ +   G                          +    I  +V  + 
Sbjct: 207 LFEWRPRSLIPVAISSAIAGALRYYLLGTPPIFPTPTHTFYPTLMVLVDCFITGLVAGLL 266

Query: 35  SVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRFSQGHAGPDPACEPLIGA- 93
           S++   +   +           +W   +  +     GL+   + G      A        
Sbjct: 267 SLILTWMVYTVEDIFRKLPVHWMWWPAIGGVFVGIGGLIYPRALGVGYDVIADMLRGQNT 326

Query: 94  -PVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARLLPRVNRMEWTILAS 152
             +    L        + L  G S G   PI+ +  ++ +              W +L+ 
Sbjct: 327 WQLILGILLVKSAIWAIALGSGTSGGVLAPILMIGGSIGIIESHIFPSMGEG-FWPMLSM 385

Query: 153 AGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGL 202
           +  +G     P+ A +   +  +          +   ++        T L
Sbjct: 386 SAVLGGAMRAPLTAIIFALELTH------DIHSVIPLILVVIVSYGFTVL 429


>UniRef50_A6TUH7 Chloride channel, core n=2 Tax=Firmicutes RepID=A6TUH7_ALKMQ
          Length = 437

 Score =  197 bits (501), Expect = 7e-49,   Method: Composition-based stats.
 Identities = 57/405 (14%), Positives = 133/405 (32%), Gaps = 28/405 (6%)

Query: 11  LLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAV 70
              L    IGI       +++ +   L ++                 + +  L L GI +
Sbjct: 26  KWVLWGSIIGILVGTTSALLINLNDFLTDVREANH------------FSLFFLPLGGIVI 73

Query: 71  GLVIRFSQGHA--GPDPACEPLIGA--PVPPSALPGLIVALILGLAGGVSLGPEHPIMTV 126
           G +  +    +  G D   E +      +P    P + V   +    G S G E   + +
Sbjct: 74  GYIYMYYGKGSRKGNDLIIEHVHHGQGKIPLRMGPIVFVCTFITHLLGGSTGREGAAIQM 133

Query: 127 NIALAVAIGARLLPRV-NRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDR 185
             +++  +         +R    I   +G  G+ FG P+A  +   + +        ++ 
Sbjct: 134 GASISEGVNRFFNVAEIDRRILIISGISGGFGSAFGAPLAGTIFGMEAIV--IGKTKYEA 191

Query: 186 LFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLP 245
                +A+  G      +   H    I +   +   +++   I++ I     ++      
Sbjct: 192 FIPCFVASFIGHFVATAWGIHHDEFIIQNIPDINTVNLMKVIILSIIFGFTSVLYSQLRH 251

Query: 246 RLHAMMHQMKNPVLVLGIGGFILGILGVIGGP--VSLFKGLDEMQQMVANQAFSTSDYFL 303
            +  +  +    +++    G I+ I           L +GL  +++              
Sbjct: 252 EIKRLSDKYLKNLMLRAFVGGIIIITLTYLIGSRDYLGRGLPMVERAFTGDVPPF----- 306

Query: 304 LAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLVV 363
             + K+    +   +GFRGG + P  F+G  LG  L   + A+PA+   +  ++ I+   
Sbjct: 307 AFLAKIIFTAITMGTGFRGGEVIPLFFIGSTLGNTLSPIM-ALPASFLAALGMIAILSGA 365

Query: 364 TRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNR 408
                 +   +  +     +        L +++      +    +
Sbjct: 366 ANTPISAFIFSVEMFKGEGITFFFM-ACLISFIFSGHHGIYGAQK 409


>UniRef50_C8VN56 ClC chloride ion channel (Eurofung) n=10 Tax=Dikarya
           RepID=C8VN56_EMENI
          Length = 828

 Score =  197 bits (501), Expect = 8e-49,   Method: Composition-based stats.
 Identities = 56/428 (13%), Positives = 124/428 (28%), Gaps = 53/428 (12%)

Query: 13  SLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGL 72
            L    +G    LI  V+  I   L ++          + Q    W          A  L
Sbjct: 117 WLVITIVGAVIGLIAAVLNIITEWLSDIKLGYCTTAFYLNQQFCCW------GAEGAAKL 170

Query: 73  VIRFSQGHAGPDPACEP------LIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTV 126
           V  F+   AG   +         ++   +    L    +AL L +A G+S+G E P +  
Sbjct: 171 VKSFAPYAAGSGISEIKCIIAGFVMKGFLGGWTLLIKSIALPLAIASGLSVGKEGPSVHF 230

Query: 127 NIALAVAIGARL----LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEV-P 181
            +     I               E     +A  +   FG+P+   L   + +     +  
Sbjct: 231 AVCTGNVISRFFTKYKRSASKTREVLTATAAAGVAVAFGSPIGGVLFSLEEVASYFPLKT 290

Query: 182 LWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAV 241
           LW   F  L+A    ++             + +       +++   I+       G + +
Sbjct: 291 LWRSYFCALVATGVLSVMNPFRTGQLVMFQVRYDRSWHFFELIFFVIIGIFGGLYGALVI 350

Query: 242 WCLPRLHAMMHQM--KNPVLVLGIGGFILGILG---------VIGGPVSLF---KGLDEM 287
               R+ A   +   ++ V+   I   +  ++          +      LF   +G  + 
Sbjct: 351 KWNLRVQAFRKKYLSQHAVVESVILAVVTAVICFPNMFLKINMTEMMEILFQECEGEHDY 410

Query: 288 QQMVANQAFS--TSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPA 345
             +  ++             ++++  ++++       G   P++ +G + G M+   V A
Sbjct: 411 HGLCESKYRWSMVFSLATATILRIFLVIISYGCKVPAGIFVPSMAIGASFGRMVGIMVQA 470

Query: 346 VP--------------------AAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLP 385
           +                                 +  +         +   +    T + 
Sbjct: 471 LHESFPDSKFFAACEPDLPCITPGTYAFLGAGAALSGIMHLTISVTVIMFELTGALTYIL 530

Query: 386 LLCIVMLP 393
              IV+  
Sbjct: 531 PTMIVVGV 538


>UniRef50_Q1CYU1 Voltage-gated chloride channel n=2 Tax=Cystobacterineae
           RepID=Q1CYU1_MYXXD
          Length = 677

 Score =  197 bits (501), Expect = 8e-49,   Method: Composition-based stats.
 Identities = 68/405 (16%), Positives = 120/405 (29%), Gaps = 25/405 (6%)

Query: 31  MKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRFSQGHAGP-DPACEP 89
           +   S L ++          +       ++   TL G+ VG ++R      G   P    
Sbjct: 131 LVALSALNSVFGHSHNLPEALPHLPWWLMLLAPTLGGVVVGRLLRDKPETHGHGVPEVVR 190

Query: 90  LIGA---PVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARL-LPRVNRM 145
            + +    +P       +VA  + +  G S G E PI+    A A  +G  L   R    
Sbjct: 191 AVKSGANALPADRGLLKLVASAITIGSGGSAGREGPIVYGGAAFASTVGRVLGFSRKELS 250

Query: 146 EWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFH 205
                 +   I A F  P+A A+   + +    E+         ++A+ AG L +     
Sbjct: 251 ILLACGAGAGISASFNAPIAGAVFAMEIILREFEL---RVFSPIILASVAGTLVSQGVMG 307

Query: 206 PHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMM----------HQMK 255
               L    Y  +   ++L+ A +           V  L  +                  
Sbjct: 308 ESAMLRHVPYELVSGGEVLAYAGLGIACGLLAFTFVQLLHGVEHYFHGHGKDRLSSWLGS 367

Query: 256 NPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVA 315
            P+ +    G +   +     P     G D +      +           ++KL A  + 
Sbjct: 368 KPLPLRAGLGGLCTGILAFASPTVWGSGHDYINLAALGR-LPFLFLITACLLKLVATALT 426

Query: 316 AASGFRGGRIFPAVFVGVALGLMLHEHVPAVPA------AITVSCAILGIVLVVTRDGWL 369
             SG  GG  FPA  +G   G      V                  + G V  +TR    
Sbjct: 427 IGSGGSGGTFFPAALIGAMAGGAFGTLVHFFFPESTGPSGAYALVGMGGAVAALTRGPLT 486

Query: 370 SLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNRPKQQPP 414
            + M   +  N  ++  L +    A  L          + +    
Sbjct: 487 GMMMLYELSGNHDIILPLMVTCTIASALCHYLTERKTPKVQSDTD 531


>UniRef50_B8FBB1 Chloride channel core n=1 Tax=Desulfatibacillum alkenivorans AK-01
           RepID=B8FBB1_DESAA
          Length = 573

 Score =  196 bits (500), Expect = 1e-48,   Method: Composition-based stats.
 Identities = 58/393 (14%), Positives = 115/393 (29%), Gaps = 27/393 (6%)

Query: 10  LLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIA 69
           + L L  V +G  S +    +      L  L                 W+  +  +    
Sbjct: 21  VALLLAGVLVGCCSGVAAAGLSFAIEHLWELCAH---------AKHYWWVFVLPGVGAAL 71

Query: 70  VGLVIRF-----SQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIM 124
             L +       +              G  +   +    +V+  L +  G S GPE P++
Sbjct: 72  SSLFLNKIVREGAGHGVPEIIYAVSRRGGLLRFRSSFSRLVSSCLTIGSGGSAGPEAPVV 131

Query: 125 TVNIALAVAIGARLLPRVNRM-EWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLW 183
               A+   I  RL              +A  I ++F  P+A  +   + + G       
Sbjct: 132 MSGSAIGSNIAQRLGFPARHRITLVGCGAAAAIASIFNAPIAGIVFTLEVVLGEWTA--- 188

Query: 184 DRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWC 243
             +    +A+ AG     L           H+      DI +   +A       +     
Sbjct: 189 VNVIPIGVASVAGTQVGRLLMGNSIRFSHTHFSPGTW-DIAAAFGLALATALISVALSRM 247

Query: 244 LPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYF- 302
           +     +  ++    +     G     L  +  P  L +G +++  ++  Q         
Sbjct: 248 IRSSGKVWGKLPASKMSRAFVGGACVGLVGLFFPQVLGEGYNQIYSLIHGQYSPGLMLLC 307

Query: 303 LLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHV-------PAVPAAITVSCA 355
            +  +K+        SG  GG   P + VG   G+     +       P  P        
Sbjct: 308 AILGLKMLVTATTLGSGGSGGIFAPGLVVGSFTGVAYFRLLSLMFDVTPLAPEGCYALLG 367

Query: 356 ILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLC 388
           + GI+  + +     LF+   +     ++  L 
Sbjct: 368 MAGIMGGMLQAPLTGLFLVVDITSGYEVILPLI 400


>UniRef50_A0NVM0 Cl-channel, voltage gated n=4 Tax=Alphaproteobacteria
           RepID=A0NVM0_9RHOB
          Length = 550

 Score =  196 bits (500), Expect = 1e-48,   Method: Composition-based stats.
 Identities = 73/405 (18%), Positives = 139/405 (34%), Gaps = 18/405 (4%)

Query: 11  LLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTL--GIAQDSPLWIIGVLTLTGI 68
           ++ L A+ IG   S   IV  +I S++Q          +    A      I+   T+ G+
Sbjct: 36  IVWLLALLIGSFVSWAAIVFREIISLVQLPWLGTATERVVSAAATLPWYVIVAGPTIGGL 95

Query: 69  AVGLVIRFSQG-----HAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPI 123
            VGL++++ Q                  G  +P        +   L L  G S G E P+
Sbjct: 96  LVGLLLQYMQPMQRTFSVADVIEARVKGGRGLPFWPGISSALITALSLGFGASAGREGPV 155

Query: 124 MTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPL 182
           + +   +  ++G    LP            A  + A F  P+A  L   + + G   +  
Sbjct: 156 VHLGATIGASVGRLFQLPDSAHRILLACGVASAVSASFNAPIAGVLFAHEVILGHYAM-- 213

Query: 183 WDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVW 242
              +    +AA  G + + L+F    +  I  +      +  + A++  ++    ++  +
Sbjct: 214 -SAISPIAIAAVTGTVFSRLWFGDVAAFVIPGHQITSYWEFPAFALLGMVSALVAILFQF 272

Query: 243 CLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYF 302
            L         +  PV +  + G  +  L  +  P  L  G +     + +Q        
Sbjct: 273 ALIGTDWFARNISMPVWLRPVTGGFVVGLIALVFPDVLGVGYETTDAALKDQLPLVML-L 331

Query: 303 LLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPA------AITVSCAI 356
            L V K AA  +  AS F GG   P++++G   G        +V         +     +
Sbjct: 332 ALLVAKTAATAITLASRFGGGIFSPSLYLGAMTGGAFGLIAASVFPELASSEGLYAILGM 391

Query: 357 LGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGK 401
             +   V    + +  +   +    TL   L + +  A  L    
Sbjct: 392 GAVAAAVLGAPFSTTMIVFELTGGYTLSIALLLTVSIATGLTQAV 436



 Score = 41.7 bits (97), Expect = 0.051,   Method: Composition-based stats.
 Identities = 35/226 (15%), Positives = 68/226 (30%), Gaps = 14/226 (6%)

Query: 180 VPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIA---IAA 236
           +  +  LF  +++  A   +   F    F    +H   +    I S    AAI    I +
Sbjct: 1   MNFFSSLFPAILSGIARLFSGIGFNVREFLRQKSHIVWLLALLIGSFVSWAAIVFREIIS 60

Query: 237 GMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSL------FKGLDEMQQM 290
            +   W       ++         + + G  +G L V      +      F   D ++  
Sbjct: 61  LVQLPWLGTATERVVSAAATLPWYVIVAGPTIGGLLVGLLLQYMQPMQRTFSVADVIEAR 120

Query: 291 VANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHV--PAVPA 348
           V          F   +       ++   G   GR  P V +G  +G  +      P    
Sbjct: 121 VKGGR---GLPFWPGISSALITALSLGFGASAGREGPVVHLGATIGASVGRLFQLPDSAH 177

Query: 349 AITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPA 394
            I ++C +   V          +  A  V+     +  +  + + A
Sbjct: 178 RILLACGVASAVSASFNAPIAGVLFAHEVILGHYAMSAISPIAIAA 223


>UniRef50_A6P174 Putative uncharacterized protein n=1 Tax=Bacteroides capillosus
           ATCC 29799 RepID=A6P174_9BACE
          Length = 423

 Score =  196 bits (500), Expect = 1e-48,   Method: Composition-based stats.
 Identities = 69/406 (16%), Positives = 138/406 (33%), Gaps = 22/406 (5%)

Query: 9   MLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGI 68
            +   + A  IG+    +  +          L  +              WI+ +L   G 
Sbjct: 18  FVKWLIFACLIGLICGGVGTLFHFAIDAAAELRGEYP------------WILWLLPAGGA 65

Query: 69  AVGLVIRF---SQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMT 125
            + L+ R+    +               P+     P +  A ++    G S G E   + 
Sbjct: 66  LIVLLYRWCGMEKDRGTNFVLVAVRENEPLRLRTAPLIFAATVITHLVGGSSGREGAALQ 125

Query: 126 VNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWD 184
           +  +++  IG  + L   +    T+   +    ALFGTP+AAA+   + +  S  V  + 
Sbjct: 126 LGGSISSKIGRWMGLDDKDSRVITMCGMSAAFSALFGTPLAAAVFSMEVV--SVGVMYYA 183

Query: 185 RLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCL 244
            +    +A+  G      F  P     +     + +   L    +  +     ++    +
Sbjct: 184 AIVPCTIASLVGVGVAASFGVPPTVYDLTGVPALSIVTALQCVGMGVLFALLSILFCRVM 243

Query: 245 PRLHAMMHQM-KNPVLVLGIGGFILGILGVIGGPVSLFK-GLDEMQQMVANQAFSTSDYF 302
                + ++    PVL   +GG ++  L  +    +      +     +  QA       
Sbjct: 244 HAAPKLYNKFIPRPVLRAAVGGALVIALTYLVWLWNPGTYDYNGAGAGLIAQAIGGQARP 303

Query: 303 LLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLV 362
              ++K+    V   +GF+GG I P  F G   G +    +  +PA    +  +  +   
Sbjct: 304 EAFLLKILFTAVTLGAGFKGGEIVPVFFTGATFGCVAAPFL-GLPATFGAALGMTAVFCG 362

Query: 363 VTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNR 408
           VT     SLF+A  +      LPL  +    A++L     +    +
Sbjct: 363 VTNCPMTSLFLAYELFGGQG-LPLFALSCAVAYMLSGYYGLYSEQK 407


>UniRef50_A1AU45 Cl-channel, voltage-gated family protein n=5 Tax=Desulfuromonadales
           RepID=A1AU45_PELPD
          Length = 481

 Score =  196 bits (499), Expect = 1e-48,   Method: Composition-based stats.
 Identities = 63/406 (15%), Positives = 137/406 (33%), Gaps = 24/406 (5%)

Query: 8   TMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTG 67
           +++  +  A  +GI S     + +   +    L               P + + +     
Sbjct: 14  SVVKWTCYASIVGILSGCGTTLFLWALAQATRLF-----------ALIPDYYLLLPVTLV 62

Query: 68  IAVGLVIRFSQ----GHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPI 123
           +    V RFS                     +P  +LP  ++A ++ +AGG S G E P 
Sbjct: 63  VCSLFVTRFSPASVCRGTDAIIEAVHQNMGRMPLLSLPIKLIATVVTIAGGGSAGKECPS 122

Query: 124 MTVNIALAVAIGARLLPRV-NRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPL 182
             +   LA A G  +     ++ +  I   +     +FGTP+A AL   + L       +
Sbjct: 123 AQIGAGLASAFGRLMRLDDVDQRKLVICGISAGFATVFGTPIAGALFGVEVLV--LGQMM 180

Query: 183 WDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVW 242
           +D LF   +A   G          +  L  +   ++         ++        ++ + 
Sbjct: 181 YDVLFPSFVAGIIGFHVASQLGVEYPHLVASAIPRLTGWSFAEMLLLGVWCGLIALLFIE 240

Query: 243 CLPRLHAMMHQ-MKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDY 301
            +     + +    N +    +GG +L ++G       L  G+D ++  +         +
Sbjct: 241 MMKLSKRLFNPCAGNAIPKALLGGTLLALIGKFLSTSYLGLGIDTIEAGLKGTVLPVEAW 300

Query: 302 FLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVL 361
                +K  A  +   SG  GG + P +F+G + G +          A      +  ++ 
Sbjct: 301 L----VKSVATAITLGSGGSGGVVTPIMFIGASAGNLFASLFNEPQIATFSIIGMAAVLA 356

Query: 362 VVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVN 407
                   +  MA  +     + P   +  + ++L++  + +    
Sbjct: 357 GAANTPIAASVMAMELFG-AGIAPNAAVACMVSFLIVGYRSIYSSQ 401


>UniRef50_A3HUV6 Putative transport related, membrane protein n=1 Tax=Algoriphagus
           sp. PR1 RepID=A3HUV6_9SPHI
          Length = 564

 Score =  196 bits (498), Expect = 2e-48,   Method: Composition-based stats.
 Identities = 61/406 (15%), Positives = 138/406 (33%), Gaps = 30/406 (7%)

Query: 18  AIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRFS 77
            IG+ S L  +++      +QN L +             L+ +  +T   +    + +  
Sbjct: 2   IIGVLSGLAAVLLKGAVHAIQNFLTEDFYNEYA-NFLYILYPMIGITAAYLVGKFIFKDV 60

Query: 78  QGHA-GPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGA 136
            GH             + +P   +   +    L +  G S+G E P++    A+    G 
Sbjct: 61  GGHGIPDVLFIISKKQSLIPRVKMYSRLFTSALTVGFGGSVGLEAPMVVTGSAIGSNTGL 120

Query: 137 RLLPRVNRMEWTI-LASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAA 195
            +     +    I   +A +I A+FG P+ A +   + +     +         L+A+  
Sbjct: 121 LMHLNGKKRALLIGCGAAASISAIFGAPIGAVIFAIEVVLLEVSIA---SFIPLLIASVT 177

Query: 196 GALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMK 255
           G+LT+ +                    +     +  I     +     + +   ++  ++
Sbjct: 178 GSLTSMILIGKESIFNFRFEETFLAAHMPYYLGLGIICGLVSLYFNRAVRKTELVLEGLE 237

Query: 256 NPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQA-----------------FST 298
           +  + +  GG +LG +     P    +G + + Q++  ++                    
Sbjct: 238 SQTIRMLYGGALLGFMV-FFFPPIYGEGYNTLNQLIDGKSAEILNRSPFFSVIENPYMII 296

Query: 299 SDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLH------EHVPAVPAAITV 352
               L+ ++K  A  +    G  GG   P+++VG  +G +             +P A   
Sbjct: 297 IFLILIILVKPIASALTIGGGGSGGIFAPSLYVGGIVGFVFAYSKNLLGFHIPLPLASFT 356

Query: 353 SCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL 398
             A+ G++  V      ++F+ A +     L   L  V   +++  
Sbjct: 357 LVAMCGVMSGVQHSPLSAIFLIAEITGGYELFVPLMFVSAISYITT 402


>UniRef50_C0XMN8 CPA2 family monovalent cation:proton (H+) antiporter-2 n=4
           Tax=Lactobacillus RepID=C0XMN8_LACHI
          Length = 513

 Score =  195 bits (497), Expect = 2e-48,   Method: Composition-based stats.
 Identities = 66/399 (16%), Positives = 136/399 (34%), Gaps = 16/399 (4%)

Query: 8   TMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTG 67
           + L      + IGI + +++ +       +  ++     G         L +   L++  
Sbjct: 13  SQLKFIFNGLIIGILAGIVVSLFRWSIQHMMTIMQILYTGIFKKPILMLLCLAINLSVGL 72

Query: 68  IAVGLVIRFSQGHAGPDPACEPLIGAPVPP---SALPGLIVALILGLAGGVSLGPEHPIM 124
           I   L+ +         P  E  +   +     S L    V  IL +  G+ LG E P +
Sbjct: 73  IIGMLLRQQPDIKGSGIPQVEGQLRDELDYPWWSVLWRKFVGGILAIGSGLYLGREGPSI 132

Query: 125 TVNIALAVAIGARLLP-RVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLW 183
            +   L   +         +R       +A  + A F  P+A+ L   + +  +    +W
Sbjct: 133 QLGSTLGQGLAHLTKQVGFDRQVLISSGAAAGLSAAFNAPIASTLFVLEEIYHNFSTNIW 192

Query: 184 DRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWC 243
                 L +A    +     F     L +     + +   +   I+       G      
Sbjct: 193 ---IVSLTSAITSDMVATYVFGLKPVLYMKSQP-LPLRYFIWVVILGIALGLLGRFYQLI 248

Query: 244 LPRLHAMMHQM-KNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYF 302
           + R+    H++ K P    GI   +L I      P  L  G + +   +    +ST    
Sbjct: 249 ILRMDGWYHRISKLPWYYQGIIPLLLIIGLGAYFPNLLGGG-NYIILKLTGAGYSTLVLC 307

Query: 303 LLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHE------HVPAVPAAITVSCAI 356
              +I+ A  +++  SG  GG   P + +G  +G ++         +     +  +   +
Sbjct: 308 AFFLIRFAFSMISYGSGLPGGIFLPILCLGGLIGAIIGNIAIQYGFISQTYFSSFIIMGM 367

Query: 357 LGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAW 395
            G    +++  + ++ +   +V   T L  L  V L A+
Sbjct: 368 AGYFAAISKAPFTAILLITEMVGTLTHLLGLATVCLIAY 406



 Score = 40.9 bits (95), Expect = 0.097,   Method: Composition-based stats.
 Identities = 28/205 (13%), Positives = 66/205 (32%), Gaps = 15/205 (7%)

Query: 213 AHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILG 272
            +Y   ++  I +G I+  +A     +  W +  +  +M  +   +    I   +   + 
Sbjct: 8   GNYKLSQLKFIFNGLIIGILAGIVVSLFRWSIQHMMTIMQILYTGIFKKPILMLLCLAIN 67

Query: 273 VIGG----------PVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRG 322
           +  G          P     G+ +++  + ++      ++ +   K    ++A  SG   
Sbjct: 68  LSVGLIIGMLLRQQPDIKGSGIPQVEGQLRDELDYP--WWSVLWRKFVGGILAIGSGLYL 125

Query: 323 GRIFPAVFVGVALGLMLHEHVPAVPAA--ITVSCAILGIVLVVTRDGWLSLFMAAVVVPN 380
           GR  P++ +G  LG  L      V     + +S      +         S       +  
Sbjct: 126 GREGPSIQLGSTLGQGLAHLTKQVGFDRQVLISSGAAAGLSAAFNAPIASTLFVLEEI-Y 184

Query: 381 TTLLPLLCIVMLPAWLLLAGKPMMM 405
                 + IV L + +        +
Sbjct: 185 HNFSTNIWIVSLTSAITSDMVATYV 209


>UniRef50_B0G1X5 Putative uncharacterized protein n=1 Tax=Dorea formicigenerans ATCC
           27755 RepID=B0G1X5_9FIRM
          Length = 428

 Score =  195 bits (496), Expect = 2e-48,   Method: Composition-based stats.
 Identities = 77/410 (18%), Positives = 154/410 (37%), Gaps = 30/410 (7%)

Query: 8   TMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTG 67
           +++   L ++ IG    +I      + +   +                 +W++ +L   G
Sbjct: 23  SLVKWILLSIVIGGVIGVIASAFANLITWATDFRMG------------HMWMVYLLPFAG 70

Query: 68  IAVGLVIRFSQ--GHAGPDPACEPLIGAP--VPPSALPGLIVALILGLAGGVSLGPEHPI 123
           + +  +   +    +AG D     +      +P    P +++A  L    G S G E   
Sbjct: 71  LMIVFLYHVTGQEKNAGTDMVLMVVRSDQNTMPGRVAPLILIATALTHLFGGSAGREGAA 130

Query: 124 MTVNIALAVAIGARLLPRV-NRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPL 182
           +    +L   +G ++     ++   T+   +    ALFGTP+AAA+   + +  S  +  
Sbjct: 131 LQFGASLGNWLGRKIHLNESDKRIMTLAGMSAAFAALFGTPMAAAVFPMEVI--SVGIMY 188

Query: 183 WDRLFAPLMAAAAGALTTGLFFHPHFS--LPIAHYGQMEMTDILSGAIVAAIAIAAGMVA 240
           +  L   + +A  G   +        +   P+               ++A     AG + 
Sbjct: 189 YAALVPCVFSAFIGERISIFMGVRTLTAPYPVEEVPNFYGIAWGKAILLAICFAFAGALF 248

Query: 241 VWCLPRLHA-MMHQMKNPVLVLGIGGFILGILGVIGGPVS-LFKGLDEMQQMVANQAFST 298
              L      +    +NP L + +GG  + +L  I G  + L  G   + Q  A      
Sbjct: 249 CVMLHIFEKQLKKWFQNPYLRVFVGGVTVVLLWKITGTDTYLGLGGGTIAQSFAEPQK-- 306

Query: 299 SDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILG 358
                + ++K+    +   SGF+GG I P++F+G   G  L      +P  I  +C ++G
Sbjct: 307 ---LWVFLLKILFTCITLCSGFKGGEIVPSLFIGATFGSALAPIF-GLPVDICAACGMVG 362

Query: 359 IVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNR 408
           +   VT     SL +A  +      +P  C V+  ++LL   + +    +
Sbjct: 363 VFCAVTNSPISSLLIAFELFG-FAGMPYFCTVIAVSYLLSGYQSLYKAQK 411



 Score = 40.9 bits (95), Expect = 0.091,   Method: Composition-based stats.
 Identities = 31/195 (15%), Positives = 53/195 (27%), Gaps = 6/195 (3%)

Query: 221 TDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSL 280
             +LS  I   I + A   A          M  M    L+   G  I+ +  V G   + 
Sbjct: 27  WILLSIVIGGVIGVIASAFANLITWATDFRMGHMWMVYLLPFAGLMIVFLYHVTGQEKNA 86

Query: 281 FKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLH 340
              +  M               L+    L A  +    G   GR   A+  G +LG  L 
Sbjct: 87  GTDMVLMVVRSDQNTMPGRVAPLI----LIATALTHLFGGSAGREGAALQFGASLGNWLG 142

Query: 341 E--HVPAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL 398
              H+      I     +      +      +      V+    +     +  + +  + 
Sbjct: 143 RKIHLNESDKRIMTLAGMSAAFAALFGTPMAAAVFPMEVISVGIMYYAALVPCVFSAFIG 202

Query: 399 AGKPMMMVNRPKQQP 413
               + M  R    P
Sbjct: 203 ERISIFMGVRTLTAP 217


>UniRef50_Q0EW01 Cl-channel, voltage gated n=1 Tax=Mariprofundus ferrooxydans PV-1
           RepID=Q0EW01_9PROT
          Length = 598

 Score =  195 bits (496), Expect = 3e-48,   Method: Composition-based stats.
 Identities = 71/419 (16%), Positives = 134/419 (31%), Gaps = 24/419 (5%)

Query: 5   RARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLT 64
           R +  + + L AV IGI S    +++      +             I        +   T
Sbjct: 19  RQQDTVFMVLLAVVIGILSGYAALLLRFAIEWVSLFWTGERTWEDAITTLPWYIYLLAPT 78

Query: 65  LTGIAVGLV-IRFSQGHA----GPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGP 119
           +TG+ V  + IRF             A        V    L   +    L + GG SLG 
Sbjct: 79  ITGLIVAWISIRFLPEGELRDVAGVLADMVERRGRVRSRLLATELAGSALAMGGGASLGR 138

Query: 120 EHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSS 178
           E P + +   +A  IG RL +            +A  I A F TP+A AL   + +    
Sbjct: 139 EGPTVALGALIASEIGQRLDMSEQQLRILIGCGAAAGIAASFNTPIAGALFALEVVLADY 198

Query: 179 EVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGM 238
            +         ++A+    +          +  +  Y  +   +I +  ++ AI      
Sbjct: 199 AIA---TFSPIVIASVLATVIARSEVGNFPAFTVPEYHLISTWEIPAYILMGAICGLVAT 255

Query: 239 VAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFS- 297
           V +  +      + ++    L+       +  L  +  P  +  G   ++ M+       
Sbjct: 256 VLIKSMTPTRIFLTRLIPNRLIRPAVVGFVVGLMGLMLPQIMSIGYGTVESMMLEHVDPH 315

Query: 298 --------TSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAA 349
                        +L + KL A ++ AA GF GG   P +F+G  +G +      A   +
Sbjct: 316 LMGYLVPLVLFLAVLLIGKLVATILCAAGGFPGGLFGPVLFLGAVVGALFGGVAHAYSPS 375

Query: 350 I------TVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKP 402
                      A   +     +     + +   +  +  ++  L      A L+     
Sbjct: 376 YSESSGAYALVACGALTAAALQAPLTVMLIVFEMTADYHIMLPLMAACSVATLVTRSFG 434


>UniRef50_C5A3X3 Voltage-gated ClC-type chloride channel n=6 Tax=Thermococcus
           RepID=C5A3X3_THEGJ
          Length = 574

 Score =  195 bits (495), Expect = 3e-48,   Method: Composition-based stats.
 Identities = 61/384 (15%), Positives = 115/384 (29%), Gaps = 18/384 (4%)

Query: 30  VMKIASVLQNLLWQRLPGTLGIAQDSP-LWIIGVLTLTGIAVGLVIRFSQGHAG----PD 84
              +        +  L   L        L  + +  + G+ V L++       G      
Sbjct: 34  FRLMIRFTHKFFFGMLLPRLSFTLYHLNLGYVLLPAIGGLFVALLVVRFPDIKGNGIPEV 93

Query: 85  PACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARL-LPRVN 143
                  G  +        IVA  + +  G S+G E PI  +  AL  A      L R  
Sbjct: 94  IEAVIFKGGRIGGVFAIAKIVATSVTIGSGGSVGREGPIGFIGAALTSAFAKWFGLSREM 153

Query: 144 RMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLF 203
           R        A  I   F TP+A A+   + +           L    +A+  G   T   
Sbjct: 154 RKLLVTCGLAAGIAGTFNTPLAGAMFALEVV---YMGAFSINLVPIFIASVTGNAVTLAV 210

Query: 204 FHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGI 263
               F + I       + ++    ++  +  A   + V  +        ++  P +   +
Sbjct: 211 LRRAFEVEIPGGMGHTLPELPFFFVLGLLLGALAALYVRVIYAFIEGFERLPVPEVFKPV 270

Query: 264 GGFILGILGVIGGPV--SLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFR 321
            G +   L     P       G + M      +         L V+K+ A  +   SG  
Sbjct: 271 LGGLGVGLLGAFFPNYGIFGVGYEGMSLAFYGK-LVVWLLLTLGVLKMLATALTIGSGQS 329

Query: 322 GGRIFPAVFVGVALGLMLHEHVPAVPAAI------TVSCAILGIVLVVTRDGWLSLFMAA 375
           GG   P++++G   G      V  +  ++           +      +T+     + M  
Sbjct: 330 GGVFAPSLYIGTMFGSAFGMVVAKLFPSLGAMPTVYALAGMAAFFSGMTQAPITQILMVT 389

Query: 376 VVVPNTTLLPLLCIVMLPAWLLLA 399
            +  +  +LP +       +L   
Sbjct: 390 ELTRSYAILPAVMTSATMGFLTAR 413


>UniRef50_B5CM99 Putative uncharacterized protein n=1 Tax=Ruminococcus lactaris ATCC
           29176 RepID=B5CM99_9FIRM
          Length = 424

 Score =  195 bits (495), Expect = 4e-48,   Method: Composition-based stats.
 Identities = 69/415 (16%), Positives = 143/415 (34%), Gaps = 26/415 (6%)

Query: 2   LHPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIG 61
           +  + +  +  S+ A+  G+A   I  +  +    L +                  +++ 
Sbjct: 1   MKEKIKCTIRYSILALVTGVAVGAIDTIFGRGLLWLSDF-----------RTAHYRYLLP 49

Query: 62  VLTLTGIAVGLVIRFSQ----GHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSL 117
            L + G+ +  +                         +P + +P +IV   L    G S 
Sbjct: 50  FLPVAGLLIVWMYHRFSEESLKGMTLVLETGQKKRKSIPLALVPLVIVGTWLTHLFGGSA 109

Query: 118 GPEHPIMTVNIALAVAIGARLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGS 177
           G E   + +   ++   G +     N     +   A   G LF TP+AA     + +   
Sbjct: 110 GREGVAVQIGAVISHEAGKKFRCPENDRIMLVAGMAAGFGGLFQTPLAAVFFAMEVIASG 169

Query: 178 SEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAH-YGQMEMTDILSGAIVAAIAIAA 236
                ++ L   +++A   A T+ +     F+  I       E   ILS  ++  +    
Sbjct: 170 YMQ--YEALLPAMISAYTAAFTSHILGLEKFTAVIGEKLDLSETKVILSLIVLGILFGLV 227

Query: 237 GMVAVWCLPRLHAMMHQ-MKNPVLVLGIGGFILGILGVIGG-PVSLFKGLDEMQQMVANQ 294
           G +    L  +   M   +KNP + +G     L +L  +         G + +     N 
Sbjct: 228 GRLFSGTLQWMKKRMGNAIKNPYIRIGAVAVFLAVLLFLFHGGRYSGLGTNLISAAFENG 287

Query: 295 AFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSC 354
                D+    ++KL   V+  A GF+GG + P   +G +LG++    +  +   +  + 
Sbjct: 288 TIYGYDW----ILKLGFTVLTLAIGFQGGEVTPLFSIGASLGILAGNLL-GISPVVCAAL 342

Query: 355 AILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNRP 409
               +    T      + +   V      +P L +V + A+L+  G  +    + 
Sbjct: 343 GYAAVFGSATNTLLAPVMIGLEVFGTENAIP-LVVVCILAYLMNGGSSIYTAQQR 396


>UniRef50_C9RMG0 Cl-channel voltage-gated family protein n=1 Tax=Fibrobacter
           succinogenes subsp. succinogenes S85 RepID=C9RMG0_FIBSS
          Length = 456

 Score =  194 bits (494), Expect = 5e-48,   Method: Composition-based stats.
 Identities = 65/418 (15%), Positives = 124/418 (29%), Gaps = 25/418 (5%)

Query: 9   MLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGI 68
            L     A  IG  + L+ +          + +         +          V  + G+
Sbjct: 17  YLPKLGLAAVIGFVTGLVAVAFHWGLERAVDWV----RMPWTLGILPWYAFAAVPAIGGL 72

Query: 69  AVGLVIRFSQGHAGPDPA-------CEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEH 121
            VGL I                        G  V     P    A I+ LA G S G E 
Sbjct: 73  VVGLFIHKVARAPETAGQGTDKMIYSFHHQGGNVRARVAPVKFFASIITLATGGSAGYEG 132

Query: 122 PIMTVNIALAVAIGARLLPRVNRM-EWTILASAGTIGALFGTPVAAALIFSQTLNGSSEV 180
           PI  +   +A  I            ++ +  +A  +GA+F  P+A AL   + L      
Sbjct: 133 PISQIGSGIASTICKFFKMPRMMRGQFLLAGTAAGLGAIFKAPLAGALTSVEMLYREDFE 192

Query: 181 PLWDRLFAPLMAAAAGALTTGLFFHPHFSL-PIAHYGQMEMTDILSGAIVAAIAIAAGMV 239
              +     ++++         F      +  +  +      ++L+ A++  +      +
Sbjct: 193 --SNAFATSIVSSVVSFAVYVAFVGTAPLIGGVPAFPFTGGVELLACALLGVLCFPFSYL 250

Query: 240 AVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVAN----QA 295
            V           +   PV +    G     L V+  P     G D +  ++A       
Sbjct: 251 YVRFYYESERRFSKWAVPVWLKPALGGAFISLLVLAYPEVSGGGFDFIDNLMAGLVPHSM 310

Query: 296 FSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAA------ 349
           +       + + K+ A  +   SG  GG   P++F+G  +G M                 
Sbjct: 311 WGVLLLLGIVLAKIVATALTVGSGGSGGVFGPSLFIGGVIGAMFAGICELAFPGVIRMPE 370

Query: 350 ITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVN 407
           + +   +        +     + M   +  + +LLP L I  +          +    
Sbjct: 371 MFILVGMASFFAGAAKAPIAGVVMVCEMTGSYSLLPGLLIASVMHIAFSRNWTIYKSQ 428


>UniRef50_B6KKS4 Chloride channel protein, putative n=6 Tax=Alveolata
           RepID=B6KKS4_TOXGO
          Length = 1590

 Score =  194 bits (493), Expect = 7e-48,   Method: Composition-based stats.
 Identities = 75/447 (16%), Positives = 140/447 (31%), Gaps = 45/447 (10%)

Query: 7   RTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLT 66
           R  + L +  V IGI ++L+   +      +       LP      Q      I   ++ 
Sbjct: 522 RERISLWIALVLIGILTALVSYFLDWGVDFVL------LPLQENAVQRHSYTAIFAYSVA 575

Query: 67  GIAVG----LVIRFSQGHAGPDPACEPLIGAPV-----PPSALPGLIVALILGLAGGVSL 117
              V     L++  SQG     P    ++                  V L+  + GG+S+
Sbjct: 576 CAVVATACCLLVPQSQGSG--IPELRTVLSGSFLPDFCAWPTFFARCVGLLACICGGLSV 633

Query: 118 GPEHPIMTVNIALAVAIGARLL------PRVNRMEWTILASAGTIGALFGTPVAAALIFS 171
           G E P++ ++  LA  +                +    +A A  + A FGTP    L   
Sbjct: 634 GKEGPVVHLSAILATQLCRLRPLQALTASPSKLLSILDVAVAAGVTATFGTPFGGVLFSI 693

Query: 172 QTLNGSSEV-PLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEM-TDILSGAIV 229
           +       V  LW   F  +       L                    ++  ++LS AI+
Sbjct: 694 EVTATFFLVHALWKSYFCCIFCVLTFRLLHERLSPIEQLYQGTQLPSFDVSWEVLSFAIL 753

Query: 230 AAIAIAAGMVAVWCLPRLHAMMHQMKNP-----VLVLGIGGFILGIL----GVIGGPVSL 280
            A+    G + VW   ++  +  +   P     +L +      L +L     V+     L
Sbjct: 754 GAVCGCLGGLFVWAASKVFQLSRKHVYPSAGRKILFVSAVMLALNVLSHHSVVLKSEDRL 813

Query: 281 FKGLDEMQQMVANQAFS---TSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGL 337
             G     + +    +S       FL  + K AA +++ A     G   P    G ALG 
Sbjct: 814 KLGEFFDVESLDTNKWSSHVFLSLFLFVLFKFAATILSVACPVPAGIFTPIFVCGAALGR 873

Query: 338 MLHEHV-----PAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVML 392
           +  + +          A         +    TR       +   +    + +  + + +L
Sbjct: 874 LYGKILRHFVPTLSSPAAYALVGAASLAAGTTRT-ISVSVIVFELTGKLSHMIPVLLAVL 932

Query: 393 PAWLLLA--GKPMMMVNRPKQQPPHDN 417
            A+ +       +  V    +  P+  
Sbjct: 933 IAYGVNGFFTISIYDVMLLIKDLPYVP 959


>UniRef50_B2KDW6 Chloride channel core n=1 Tax=Elusimicrobium minutum Pei191
           RepID=B2KDW6_ELUMP
          Length = 494

 Score =  193 bits (492), Expect = 7e-48,   Method: Composition-based stats.
 Identities = 61/375 (16%), Positives = 124/375 (33%), Gaps = 13/375 (3%)

Query: 41  LWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRFSQGH---AGPDPACEPLIGAPVPP 97
               L  ++      P + +G+  +  +   L  R        +      +     P+  
Sbjct: 33  FLFILDHSISTTTSFPFYYVGLPFVFILTSFLSKRVFPKDTDFSTDAAINKINAYKPISL 92

Query: 98  SALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTI 156
            +        +L ++ G S G E P   V   LA      L L   +R +  I   +   
Sbjct: 93  ISAAKAFFLPVLTISAGGSAGKEAPCADVGAGLASFSARLLKLSNEDRRKLMICGVSAGF 152

Query: 157 GALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYG 216
             +FG P++ A+   + L        ++ +F  L+A       T      +   PI    
Sbjct: 153 AGVFGVPISGAIFGLEVL--WVGYIFYEVMFPALVAGITAYQVTSALGVTYIYHPIPVVP 210

Query: 217 QMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPV---LVLGIGGFILGILGV 273
                  L             ++ +  +     +   +            GG IL  +G+
Sbjct: 211 VFTEGFFLKILFAGLFFGLISLLFIEIMKLFRVVFRYISIKFSFFWKAFTGGAILVAVGL 270

Query: 274 IGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGV 333
           +  P  L  G++E   ++   A  +     L   K+    +  ++G  GG + P  F+G 
Sbjct: 271 LLSPEFLGLGMEETNAILHGSAEPSFALGSLF--KMITTAITFSAGGVGGIVTPIFFIGS 328

Query: 334 ALGLMLHEHVPAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLP 393
             G +L E +   P A   +  ++ ++   T     S  MA  +     + P   +  + 
Sbjct: 329 QAGAVLGEFLQIDP-ATVAALGVVAVLAGATNAPLASSIMAIELFG-PQIAPYAAVCCVI 386

Query: 394 AWLLLAGKPMMMVNR 408
           ++L+   + +    R
Sbjct: 387 SFLVTGQRSVFAKQR 401


>UniRef50_A3EVY7 Putative Cl-channel, voltage gated n=2 Tax=Leptospirillum sp. Group
           II RepID=A3EVY7_9BACT
          Length = 570

 Score =  193 bits (492), Expect = 9e-48,   Method: Composition-based stats.
 Identities = 68/423 (16%), Positives = 149/423 (35%), Gaps = 25/423 (5%)

Query: 5   RARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLT 64
           R      + + A+ IGI + L++ ++  +   L  L         GI       I+ V+ 
Sbjct: 21  RINRFWRVLILALLIGIVTGLLVYLLESVVYELLFLTLYNTYFKNGI-------IVIVIP 73

Query: 65  LTGIAV---GLVIRFSQGHAGPDPACEPLI--GAPVPPSALPGLIVALILGLAGGVSLGP 119
           + G+ +    LV   + G  G +   +        +P S  P  I A I  L  G S G 
Sbjct: 74  MIGVLLTRLILVWGKTDGMGGTEEVVKSYHEFRGRLPLSRTPYKIPAYITTLGFGGSAGL 133

Query: 120 EHPIMTVNIALAVAIGARL----LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLN 175
           E     +   ++      +    +P   +    +  +   + A+F  P+   +   Q   
Sbjct: 134 EGASTYIGGMVSSIAEKIMEKLNIPFEEQRTLLLAGAGAGLSAMFKAPLTGTIFILQVPY 193

Query: 176 GSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIA 235
            S   P  + L   L+A+ +  +        H    +A+     M D+L+  ++  +   
Sbjct: 194 KSDLAP--NALIPTLVASVSSYIVMVTLKGTHPLFSMANKADFHMNDMLAVIVIGLVCGF 251

Query: 236 AGMVAVWCLPRLHAMMHQMKNPV----LVLGIGGFILGILGVIGGPVSL--FKGLDEMQQ 289
                +           +    +    ++  +   I G L  +    +L    G   +Q 
Sbjct: 252 LSKYFLRVYRATKTWFLKGPARLTSRNVLAALILGITGYLATLRFGEALPLGPGYIFIQY 311

Query: 290 MVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAA 349
           +++    +  +  +L ++K+AA++   ++G  GG  FP + +G A G ++       P  
Sbjct: 312 LLS-VPDTFLNLLMLLLLKMAAVIFTFSAGGMGGSFFPLLCLGAATGGLISNVAHIQPFD 370

Query: 350 ITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNRP 409
             V   + G +    +    ++   A    ++  L    I    +++      +    R 
Sbjct: 371 FGVVMGMAGFLAAGYKTPLAAVVFVAESTHSSGYLIPGLICTAFSYIASGASSISSQQRE 430

Query: 410 KQQ 412
           ++ 
Sbjct: 431 RED 433


>UniRef50_C7QDN8 Chloride channel core n=3 Tax=Actinomycetales RepID=C7QDN8_CATAD
          Length = 633

 Score =  193 bits (490), Expect = 1e-47,   Method: Composition-based stats.
 Identities = 69/401 (17%), Positives = 139/401 (34%), Gaps = 14/401 (3%)

Query: 8   TMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQ---RLPGTLGIAQDSPLWIIGVLT 64
            +++++  AV IG+  +L    ++K+ +++ N+ +     L             I  +  
Sbjct: 55  RVVVITAVAVPIGVCGALAAYALLKLITLVTNICFYAQFTLHSASPADTPHRWLIPILPV 114

Query: 65  LTGIAVGLVIRFS-----QGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGP 119
           + G+ VGL+ R+                  + G+ V P       ++  + +  G   G 
Sbjct: 115 VGGLVVGLMARYGSDKIRGHGMPEAIEAILIGGSKVQPRVAVLKPLSAAVSIGTGGPFGA 174

Query: 120 EHPIMTVNIALAVAIGARLL-PRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSS 178
           E PI+    A+   +   L      R    +  SA  + A F TP+AA ++  + L    
Sbjct: 175 EGPIIMTGGAIGSLLAQVLHVTTDERKTLLVAGSAAGMAATFNTPLAAVVLAVELLLFEW 234

Query: 179 EVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYG-QMEMTDILSGAIVAAIAIAAG 237
                  L     AA    +  G           AH    +   D     +   +A    
Sbjct: 235 RP---RSLIPVAAAAVTATIVRGPMLGYGPLFGGAHVPAHLAFYDYPLCLVAGVVAGLLA 291

Query: 238 MVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFS 297
           + A   +        ++    +     G  +  +G +  P +L  G D +  ++  +A +
Sbjct: 292 IGATALVYFSEDSFAKLPIHWMWWPAIGGAIVGVGGLIEPHALGVGYDVIDSLLTGRATT 351

Query: 298 TSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAIL 357
                 + V+K     ++  SG  GG + P   VG ALG       P+V        ++ 
Sbjct: 352 G-LIVGILVVKTLIWGLSLGSGTSGGVLAPMFMVGGALGAAEAMIFPSVSPGFWALVSLA 410

Query: 358 GIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL 398
           G++  V R     +     +      +  + +    A+L+ 
Sbjct: 411 GVLGGVMRSPLTGIVFCLELTHEVNAILPMIVTAGTAYLVS 451


>UniRef50_A4BAH0 Chloride channel protein EriC n=1 Tax=Reinekea blandensis MED297
           RepID=A4BAH0_9GAMM
          Length = 572

 Score =  193 bits (490), Expect = 1e-47,   Method: Composition-based stats.
 Identities = 69/403 (17%), Positives = 137/403 (33%), Gaps = 16/403 (3%)

Query: 11  LLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAV 70
           LLS+  VA G+A+SL+++  M    +  + L  +     G    SP   + +     + +
Sbjct: 21  LLSVLGVATGLATSLVIVGFMLAIDLTTSAL--QAGQETGFEGFSPWVRLLLPLTGSVLL 78

Query: 71  GLVIRFSQG-----HAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMT 125
            L+ R +                      +P         A ++ L GG SLG E P + 
Sbjct: 79  ILLYRLTPTERQDVGITHVIDRLQRGRGRLPLGNTFFQFFAALITLTGGFSLGKEGPAVH 138

Query: 126 VNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWD 184
           V   +A  +G  +          T   +A  I A FGTP+A  L   + +     +    
Sbjct: 139 VGSGIASRLGLAVHRSPSQLRLLTGCGTAAAISAAFGTPLAGVLFAMEVVLMEYSLT--- 195

Query: 185 RLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCL 244
                + AA    ++T      H       +        +   ++     A   +    +
Sbjct: 196 GFIPIIAAAVTATVSTQFIMGEHPVFLQVSFDSSADLPFVWLVVLGVATGAIAALMHKFI 255

Query: 245 PRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLL 304
            ++ A+    +       +   ++  L  +  P  L  G   M  + A +         +
Sbjct: 256 KQILALNIVNRE---WRFLTAGLITGLIGMALPQILGLGYGTMNSIAAGE-LGFMLLLAV 311

Query: 305 AVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVP-AVPAAITVSCAILGIVLVV 363
            V K+AA  VA   G   G + P++ +G+A G ++    P     A+     + G++  +
Sbjct: 312 LVGKIAATSVAVGFGIPAGIVAPSLVIGMATGALIGGLAPDQSNNAVFALVGMAGMMSAL 371

Query: 364 TRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMV 406
                 +L     +      +    +V++ + L      +   
Sbjct: 372 LHAPLAALTAVLELSLTAETMFPAMVVVVLSNLTCQVVFLQPS 414


>UniRef50_B7FTG7 Predicted protein n=2 Tax=cellular organisms RepID=B7FTG7_PHATR
          Length = 588

 Score =  193 bits (490), Expect = 1e-47,   Method: Composition-based stats.
 Identities = 68/448 (15%), Positives = 135/448 (30%), Gaps = 67/448 (14%)

Query: 13  SLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVG- 71
              A  +GI +   + +     + +++L ++++       Q +P+ ++ V  + G AVG 
Sbjct: 116 LFQAGIVGIFTGFSVALFKLSINAVKSLCYRQI-----FFQTNPVLMVTVPAMGGAAVGV 170

Query: 72  --LVIRFSQGHAGPDPACEPLIGAPVPPSA--------LPGLIVALILGLAGGVSLGPEH 121
             L+  F  G  G     +      V                  A  + L  G SLGPE 
Sbjct: 171 LMLLGDFPPGLRGTVIEVDKESQGTVQKLRDRVQTQFRFLRKSAAATVTLGTGCSLGPEG 230

Query: 122 PIMTVNIALAVAIGARLLPRVNR-----MEWTILASAGTIGALFGTPVAAALIFSQTLNG 176
           P + + + +A +          R            +A  + A F  P+A      + ++ 
Sbjct: 231 PCVEIGMDVARSCMDISRRTAERQRLWNRMLLSCGAAAGVSAGFNAPIAGTFFALEIMHR 290

Query: 177 SSEV-----------------PLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQM- 218
                                     +   L+A+   AL        H  L +     + 
Sbjct: 291 MFSSIDGEENADKDASAGLSSLNTATIAPVLIASVMSALCARTLLGDHLVLALGGSYSLK 350

Query: 219 -EMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMM-----------HQMKNPVLVLGIGGF 266
             + ++    ++  ++               A+                       + G 
Sbjct: 351 KPLIELPLYMVLGLVSGTVSFAFSRAANLSQAVFVGDYGSDRFRMGVRSLSPAFKPVIGG 410

Query: 267 ILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIF 326
           IL  L  I  P  LF G D +  ++AN +  T     L   K++   ++A SG  GG   
Sbjct: 411 ILCGLVGIKFPQILFFGYDCLNPLLANNSLPTPLLLSLLAAKISITAISAGSGLVGGTFA 470

Query: 327 PAVFVGVALGLMLHEHVPAV----------------PAAITVSCAILGIVLVVTRDGWLS 370
           P++F+G   G   H  V ++                            ++  + R    +
Sbjct: 471 PSLFLGAVTGAAFHNIVSSILYCGLGLSAASGPLLADVPAYAMVGAGSVLAALFRAPLTA 530

Query: 371 LFMAAVVVPNTTLLPLLCIVMLPAWLLL 398
             +   V  +  ++  L        +  
Sbjct: 531 CLLLFEVTRDYDVILPLMASAGFGSVFA 558


>UniRef50_A5VHY5 Chloride channel, core n=9 Tax=Lactobacillus reuteri
           RepID=A5VHY5_LACRD
          Length = 445

 Score =  193 bits (490), Expect = 1e-47,   Method: Composition-based stats.
 Identities = 58/415 (13%), Positives = 127/415 (30%), Gaps = 21/415 (5%)

Query: 11  LLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAV 70
                ++AIGI + L++ V   I      LL    P           +++G   +  +  
Sbjct: 26  RYLGVSIAIGIVTGLVIGVFRWIIDHTLTLLTIIYPFMGKHPLVLIPYVLGTFIVAWLIG 85

Query: 71  GLVIRFS----QGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTV 126
            +V  +     +       A             L    VA +L +  G+ LG E P + +
Sbjct: 86  KIVKPYEEDVVRSGVTQLKAVLLGRHRIHWWPVLWRKFVASLLTICPGLFLGREGPSIQI 145

Query: 127 NIALAVAIGARL--LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWD 184
              +      +   L   ++        A  + A F  P+A  +   + +  +    +W 
Sbjct: 146 GACIGACFNEKFFHLTDKDKYLLMECGVAAGLSAAFSAPLAGTMFLLEEMTHNFNSRIW- 204

Query: 185 RLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCL 244
                L ++   A  T LFF     L I    ++ +       I             +  
Sbjct: 205 --IPALTSSIVSAFITFLFFGIKPCLYIPITTKLPVASYPWLIIAGVAIGFLAYCFQFAA 262

Query: 245 PRLHAMMHQMK-NPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQ-----QMVANQAFST 298
             L     ++   P     I   +L I   +  P  L    D ++      +  N     
Sbjct: 263 LNLTWWYSKITFIPKEFHSIIPLLLVIPVGLWNPYILGGSHDFIKYVTNMSLSTNWQAMV 322

Query: 299 SDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHV------PAVPAAITV 352
           +   +  +++    ++A  +   GG   P   +G  +G +    +      PA      +
Sbjct: 323 AILLVYFILRFGGTMIAYGATVPGGIFMPLFVLGTVVGALTGTILIHMGIIPASCYVNVI 382

Query: 353 SCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVN 407
             ++           + ++ +   +V +   +  + ++ L A+ +          
Sbjct: 383 IISMAAYFGGAEGLPFTAILLVTEMVGSVEQILPMTLITLVAYYVNRLLGGRPSL 437


>UniRef50_B8DM62 Chloride channel core n=3 Tax=Desulfovibrionales RepID=B8DM62_DESVM
          Length = 605

 Score =  192 bits (489), Expect = 2e-47,   Method: Composition-based stats.
 Identities = 68/389 (17%), Positives = 123/389 (31%), Gaps = 22/389 (5%)

Query: 46  PGTLGIAQDSPLWIIGVLTLTGIAVGLVIRFS------QGHAGPDPACEPLI--GAPVPP 97
                     P  I+  L +TG+  G +++            G D            +  
Sbjct: 73  HAEAAARAYRPWVIVAALGITGLVTGWLVQRFLPNSLDGMTDGTDAMIRAFHAEKGVIRR 132

Query: 98  SALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTI 156
            A     +  I  +A G S G E P+  +   +   +  RL L    R    +  +AG +
Sbjct: 133 RAPLLKGLTSICTIAAGGSAGREGPVSQIGAGIGSWLSMRLGLSPRERRILMLAGAAGGL 192

Query: 157 GALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYG 216
           GA+F  P+  AL   + L         + L   ++++          F       I  + 
Sbjct: 193 GAVFRAPLGGALTAIEVLYREDFE--SEALLPAVLSSVVSYSLFTFVFGTAPIFGIPRFS 250

Query: 217 QMEMTDILSGAIVAAIAIAAGMVAVWCLPRLH-AMMHQMKNP--VLVLGIGGFILGILGV 273
              + ++    +++    A G   V     L  ++  +++    ++     G +L  L  
Sbjct: 251 FTSVLELPWYLLLSLACAATGWAYVRTFRVLKYSVFGKLRARVGIMWTTALGGVLMGLFG 310

Query: 274 IGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGV 333
           I  P  L  G   ++Q +  Q         + + K  A  V   SG  GG   PA+FVG 
Sbjct: 311 ILYPPVLSDGYGWIEQAILGQ-LPVVTMVTILLGKTLATAVTLGSGMSGGMFAPALFVGG 369

Query: 334 ALGLMLHEHVPAVPAAI------TVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLL 387
             G ++      V   +       V   +      +       L M   +     LL  L
Sbjct: 370 MTGGVVGFAAQQVQPGVVTQPGGYVLVGMAAFFAGIAHAPIGPLVMVCELTQGYGLLAPL 429

Query: 388 CIVMLPAWLLLAGKPMMMVNRPKQ-QPPH 415
            +      LL     +       + + P 
Sbjct: 430 MLSSAVCILLGRRTALYENQVENKFESPA 458


>UniRef50_A9BT15 Chloride channel core n=9 Tax=Bacteria RepID=A9BT15_DELAS
          Length = 431

 Score =  192 bits (489), Expect = 2e-47,   Method: Composition-based stats.
 Identities = 65/403 (16%), Positives = 139/403 (34%), Gaps = 24/403 (5%)

Query: 11  LLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAV 70
              + A  +   +       +    +                +++  WII +L   G+AV
Sbjct: 18  KWFIFATLVAALAGTASAFFLLSLDLATAW------------REAHPWIIWLLPFAGMAV 65

Query: 71  GLVIRFSQGHAGP----DPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTV 126
           GLV                         VP   +P ++   ++    G S+G E   + +
Sbjct: 66  GLVYFLLGKRVDGGNNLLIEEIHDPKQVVPLRMVPLVLGGTVISHLFGASVGREGTAVQM 125

Query: 127 NIALAVAIGARLLPRV-NRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDR 185
             ALA  +         +R    +   +    ++FGTP+A A+   + L  +     +D 
Sbjct: 126 GGALADQLTHVFRLHQDDRRVLLMSGISAGFASVFGTPLAGAVFGLEVL--AIGRMRYDA 183

Query: 186 LFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLP 245
           LF  ++AA         +   H    ++    ++   +++  I   +    GM+    + 
Sbjct: 184 LFPCIVAAFVADQVCTAWGVHHTHYAMSAVNNIDAWSVVAVIIAGILFGLVGMLFATAVH 243

Query: 246 RLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLA 305
           ++ A++  +     +    G ++    V       + GL         ++F         
Sbjct: 244 KIGALVKHLIAYPPLRPFFGGLVIATAVWALDAYRYIGLGIPDIA---RSFQEPMLPWDF 300

Query: 306 VIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLVVTR 365
           + KL   V +  +GF+GG + P  ++G  +G +L   +  +P A+  +   + +      
Sbjct: 301 LGKLVFTVASLGTGFKGGEVTPLFYIGATMGNVLAPLLH-MPFALMAAIGFVAVFAGAAN 359

Query: 366 DGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNR 408
               +  MA  +     + PL  I  + A+L      +    R
Sbjct: 360 TPIATTLMAMELFG-AGIGPLAAIGCVTAYLFSGHAGIYHAQR 401


>UniRef50_Q0ABK0 Cl-channel, voltage-gated family protein n=1 Tax=Alkalilimnicola
           ehrlichii MLHE-1 RepID=Q0ABK0_ALHEH
          Length = 575

 Score =  192 bits (488), Expect = 2e-47,   Method: Composition-based stats.
 Identities = 64/417 (15%), Positives = 138/417 (33%), Gaps = 25/417 (5%)

Query: 11  LLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAV 70
           L++L AV  G+A+  +++    +    Q  L         +      W + +  + G  +
Sbjct: 23  LMALLAVLCGLATGGVILGFRWVVESSQTGLLGGPEQFWALPAH---WRVLLPVIGGALI 79

Query: 71  GLVIRFSQG-----HAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMT 125
           GL++++ +                     +         V     L  G S+G E P + 
Sbjct: 80  GLMLQWLRPEHRGTGVVHVMERLGYHQGYMSWRNAAAQFVGASTALISGHSVGREGPAIH 139

Query: 126 VNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWD 184
           +  A    +G RL LP  +         AG IGA F TP+A  +   + +     +    
Sbjct: 140 LGAASGSLLGQRLGLPNNSLRTLVACGVAGAIGATFNTPLAGVIFAMEVVMLEYTL---S 196

Query: 185 RLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCL 244
                +++A    + T L +    +  +       + ++    +   +        +  L
Sbjct: 197 GFLPVMLSAVTATVVTQLVYGNTPAFSVPAVHLESLGELGWLLVCGLLIGTLAAAFIQSL 256

Query: 245 PRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLL 304
                 + +   P+        +   L  +  P  +  G + +  ++  +  +      L
Sbjct: 257 MFFSNSLTRW--PLAARTTLAGLAVGLIGLALPEVMGVGYETVNLILLGEVATI-TLVAL 313

Query: 305 AVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVP------AAITVSCAILG 358
              KL A  +A   G  GG I P V +G A G +L +   A+        ++ V   +  
Sbjct: 314 VAAKLLASTLAVGLGIPGGLIGPTVVIGAAAGGLLGQAAQALFPEMASEPSLYVMLGLGA 373

Query: 359 IVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGK----PMMMVNRPKQ 411
           ++    R    +L     +  N  ++    + +  A L          + +    ++
Sbjct: 374 MMGATLRAPLAALTAMLELTANPNIILPGMLTIATAVLCSGELFGKDSVYLHQLRRR 430


>UniRef50_B2UN00 Chloride channel core n=1 Tax=Akkermansia muciniphila ATCC BAA-835
           RepID=B2UN00_AKKM8
          Length = 595

 Score =  192 bits (488), Expect = 3e-47,   Method: Composition-based stats.
 Identities = 66/405 (16%), Positives = 146/405 (36%), Gaps = 16/405 (3%)

Query: 3   HPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGT--LGIAQDSPLWII 60
           H +     +  + AV +G+  S + +    +  V+Q +L      +     +   P W +
Sbjct: 25  HWKVGERQVTYVWAVLVGMVGSCMSLFFEWMVEVIQWMLTGIWSDSRVGTFSLVEPEWRM 84

Query: 61  GVLTLTGIAVG----LVIRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVS 116
            +    G+  G     + +   G A        +    +   A    + +    +A G +
Sbjct: 85  FIPVAGGLVAGCILLFLKKRMPGQAMEYMEAMSIGNGLIKFRASALKVFSAAWSIASGAA 144

Query: 117 LGPEHPIMTVNIALAVAIGARLLPRVNR-MEWTILASAGTIGALFGTPVAAALIFSQTLN 175
           +G E PI+  +  +A  +G RL   + R        +A      F  P +  L  S+ + 
Sbjct: 145 IGKEGPIIQSSALIASTVGQRLHVSIPRLRLLVGCGAAAGFTTAFHAPFSGCLFVSEIII 204

Query: 176 GSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIA 235
           G+  +   D L   L+A+  G +   L   P              +  L    + A A  
Sbjct: 205 GTVSM---DILAPLLIASCTGFVMLHLLGDPSPLYSSPFESFTVFSQSLWCIALGAAAAV 261

Query: 236 AGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQA 295
           A    V  L      ++  ++ + +      ++  +  +  P  +  G   +  +V ++ 
Sbjct: 262 AARGWVSLLDAAARYLNGRQSLLPLRLAAAGLVVGILAVFYPEVVGNGQALITGLV-HED 320

Query: 296 FSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAV-----PAAI 350
           + T +  +L ++K++A+ V    G  GG + P ++VG  +G +    + ++         
Sbjct: 321 YGTREALVLLLVKVSAVAVVFGCGTVGGAMTPTLYVGSMVGFIFSTVLTSLGMEGNHTVA 380

Query: 351 TVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAW 395
                +     V  +    +L M      +  ++  L I ++ A+
Sbjct: 381 YAMVGMASFFAVAAQAPLTALVMVVEFSMSGQMIYPLLIGVVSAY 425


>UniRef50_B2UP88 Chloride channel core n=1 Tax=Akkermansia muciniphila ATCC BAA-835
           RepID=B2UP88_AKKM8
          Length = 596

 Score =  191 bits (487), Expect = 3e-47,   Method: Composition-based stats.
 Identities = 74/421 (17%), Positives = 144/421 (34%), Gaps = 23/421 (5%)

Query: 11  LLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTL-----GIAQDSPLWIIGVLTL 65
           ++ + AV +G   +L+ +V      ++Q++L  R           +A   P W I V   
Sbjct: 36  VIFIWAVVVGALGALMALVFEMGVELVQDVLTGRTSYRQIQVFQEMANQDPAWCIFVPAA 95

Query: 66  TGIAVG----LVIRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEH 121
            G+  G       RF    A        L    VPP       ++ +  +  G S+G E 
Sbjct: 96  GGLLAGLTLLFTHRFVPAKATEYMEAVALGNGYVPPKPSLLRSLSAVFSVGSGASIGREG 155

Query: 122 PIMTVNIALAVAIGARLLPRVNR-MEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEV 180
           P++        A+G        R       A+A  + + F TP+A  L  S+ + G+  +
Sbjct: 156 PLVQAAAVAGSALGRFFHLSAPRLRLVVACAAASGMSSAFHTPLAGGLFVSEIVLGALTI 215

Query: 181 PLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEM-TDILSGAIVAAIAIAAGMV 239
                L   L+A+ AG  T GLF  P     +     +     +L   ++ A+A      
Sbjct: 216 DF---LAPLLVASCAGYFTMGLFHEPAPIYQLQQEVSLAGNQHVLWCVLLGALASLVASF 272

Query: 240 AVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTS 299
            +  L +    ++  +  + V      +L     I  P  +  G + +  ++ +  F  +
Sbjct: 273 WLLILKKSRRYLNGKRQWLPVRLTAAGVLVGAIAIFYPEIVGNGKNIITSLI-HYEFDAA 331

Query: 300 DYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHV-----PAVPAAITVSC 354
              +L  +K+  + +    G  GG + P++ +G   G +    +     P   A      
Sbjct: 332 RAAVLLFLKIFTVAIVFGVGTVGGALTPSLTIGSVCGFLFSAALTQLGVPGDHAIAYSLV 391

Query: 355 AILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNRPKQQPP 414
            +             SL +         ++  L I +L ++       +           
Sbjct: 392 GMAAFFTTAANAPITSLVLVVEFTMAGQMMFPLIIGVLVSY---GMARLTKAQSMYHDSL 448

Query: 415 H 415
            
Sbjct: 449 A 449


>UniRef50_C7PDX9 Chloride channel core n=3 Tax=Bacteria RepID=C7PDX9_CHIPD
          Length = 453

 Score =  191 bits (487), Expect = 3e-47,   Method: Composition-based stats.
 Identities = 68/425 (16%), Positives = 137/425 (32%), Gaps = 42/425 (9%)

Query: 6   ARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTL 65
           A  +L  ++  V + +    ++ + + +   +  L WQ              W++ +L +
Sbjct: 39  AYQLLRWTIIIVPVSLIVGSLVALFLWLLEEVTLLRWQ------------HGWLLFLLPI 86

Query: 66  TGIAVGLVIRFSQGHA----GPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEH 121
            GI +  + +   G +              G  VP    P +I   I+    G S G E 
Sbjct: 87  AGILIHFLYKKLGGTSEAGNNLIMDEIHEPGGGVPARMAPLVIATTIITHLFGGSAGREG 146

Query: 122 PIMTVNIALAVAIGARLL-PRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEV 180
             + +  ++A  +G        +     +   A   GA+FGTP+  A+   + L  +  +
Sbjct: 147 TAVQIGGSMAHMLGRWFRLSAADVKIILMTGIAAGFGAVFGTPLTGAVFALEVL--AIGL 204

Query: 181 PLWDRLFAPLMAAAAGALTTGLFFHPHFSLPI--------AHYGQMEMTDILSGAIVAAI 232
             +D L   L+AA    +    +   H    I         H+   ++  ++        
Sbjct: 205 MRYDALIPCLIAAVFADIVCSAWGIHHTHYQILFESNHISFHFVHFDLLLLIKVIACGIA 264

Query: 233 AIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDE------ 286
              A  +   C+  + +         L++   G ++ I G        + GL        
Sbjct: 265 FGLASFLFATCMRNIKSYAKAWIKIPLLIPAIGGLIVIGGCYLLGTRDYIGLGVTTPDPN 324

Query: 287 ---MQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHV 343
              +      +  S+  +      KL    +    GF+GG + P  F+G  LG  L   +
Sbjct: 325 GVSIVNAFTTKEISSWGWLW----KLLLTAITLGMGFKGGEVTPLFFIGATLGHTLAVLM 380

Query: 344 PAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPM 403
              P  +      + +    T        M   +   TT +    +    A+       +
Sbjct: 381 -GAPVDLFAGLGFIAVFAGATNTPIACTLMGVELFG-TTHVLYFAVACFTAYYFSGHAGI 438

Query: 404 MMVNR 408
               R
Sbjct: 439 YSAQR 443


>UniRef50_A0YAR4 Chloride channel protein EriC n=1 Tax=marine gamma proteobacterium
           HTCC2143 RepID=A0YAR4_9GAMM
          Length = 576

 Score =  191 bits (487), Expect = 3e-47,   Method: Composition-based stats.
 Identities = 63/420 (15%), Positives = 130/420 (30%), Gaps = 23/420 (5%)

Query: 6   ARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTL 65
           A ++L LS+  V  G + +L++++   +       LW                   +  +
Sbjct: 16  ADSLLPLSILGVVSGFSCALVILLFRYLIETPSA-LWLPNNDAENFEALPQWAHFALPVM 74

Query: 66  TGIAVGLVIRF-----SQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPE 120
             I +GL +       S+           L    +P              +A G S G E
Sbjct: 75  GAIIIGLFLSRMKPENSRTGIVHVITRFHLDHGHLPLKNALVQFFGGAFAIATGQSGGRE 134

Query: 121 HPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSE 179
            P + +  A    +G +L LP  +         A  I A F TP+A  +   + +     
Sbjct: 135 GPAIHLGAAANSLLGQKLMLPNNSIRLLVGCGIAAAIAASFNTPIAGVIFAMEVVMLEYT 194

Query: 180 VPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMV 239
           V         ++A       T           I       + +I   A++         +
Sbjct: 195 V---GGFIPVMLATITSTAMTRAVHGSEMIFSIPPISMASLWEIPFIALLGLAVGCCAAL 251

Query: 240 AVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTS 299
            +  L        +   P+L   +   ++     +  P  +  G D +   +AN+   T 
Sbjct: 252 FMVILKTALRYNDK---PILPRMVLAGLITGCCALLVPEIMGIGYDSLNAALANKLPLTV 308

Query: 300 DYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPA------AITVS 353
              L+    + A   ++  G   G I P + +G  +G  + +    +        +  V 
Sbjct: 309 LLLLIIAK-IIATATSSGLGMPIGLIGPNLLIGACIGSAMGDLGVNLFPDLASNHSFYVL 367

Query: 354 CAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNRPKQQP 413
             +  ++  V      +L        +T+++    + +  A L       +   +   Q 
Sbjct: 368 LGMGAMMGAVLNAPLAALMALLEFSNDTSMIFPGMLAITIATLTN---SELFNQKSAHQT 424


>UniRef50_C6XZM8 Chloride channel core n=3 Tax=Sphingobacteriaceae
           RepID=C6XZM8_PEDHD
          Length = 594

 Score =  191 bits (485), Expect = 5e-47,   Method: Composition-based stats.
 Identities = 67/424 (15%), Positives = 146/424 (34%), Gaps = 42/424 (9%)

Query: 12  LSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVG 71
           L + A+ +GI + L   ++  +   +++ L        G       ++       GI + 
Sbjct: 26  LVIAALIVGILAGLAAALLKSLTHHIEDFL------QTGFHWQYKYYLFFFFPFIGILLS 79

Query: 72  LVIRFSQGHAG-------PDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIM 124
           ++        G       P         + + P  +   ++   L +  G S G E PI+
Sbjct: 80  VLYVRRFIRKGKFETGLTPILYTISKKSSKIEPHNIYSQVITAALTVGFGGSTGLEAPIV 139

Query: 125 TVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLW 183
           T    +   +G  L L            +A  I   F +P+A  +   + L     +P  
Sbjct: 140 TSGGGIGSVVGRFLGLSYRETTMLLACGAAAGIAGAFNSPIAGIVFAIEILLPEFTIP-- 197

Query: 184 DRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWC 243
                 L++AA  A+   LF++      +      +M  ++   ++A +     +     
Sbjct: 198 -AFIPLLLSAATAAVVARLFYNEQLFFLVTE--GWKMNALIYYVLLAVLIGLFSIYFKKV 254

Query: 244 LPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAF------- 296
              +    ++++NP   + +GG +LG + V   P    +G   ++ ++            
Sbjct: 255 NSFIKTSFYKIRNPYKKVVLGGLMLG-IMVFLFPTLYGEGYITIKNLLGGNYTTLLSNSI 313

Query: 297 -----STSDYFLLA-----VIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVP-- 344
                S     +L        K AA ++  ++G  GG   P++ +G  +G  +   +   
Sbjct: 314 FAEYSSLPWVIILFTVVTVFAKSAATLITLSAGGNGGIFAPSLIMGGLIGFAVAFAINTL 373

Query: 345 ---AVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGK 401
               +  A  +   +   +  +       +F+ A +     L+  L I    A+L+   K
Sbjct: 374 GLAHLSVANFIVAGMAASLSAIMHAPLTGIFLIAEITGGYVLMVPLMITSAIAYLINRSK 433

Query: 402 PMMM 405
               
Sbjct: 434 HKYS 437



 Score = 49.4 bits (117), Expect = 2e-04,   Method: Composition-based stats.
 Identities = 29/209 (13%), Positives = 71/209 (33%), Gaps = 17/209 (8%)

Query: 4   PRARTMLLLSLPAVAIGIAS-------SLILIVVMKIASVLQNLLWQRLPGTLGIAQDSP 56
            +   ++   L AV IG+ S       S I     KI +  + ++   L   + +     
Sbjct: 229 WKMNALIYYVLLAVLIGLFSIYFKKVNSFIKTSFYKIRNPYKKVVLGGLMLGIMVFLFPT 288

Query: 57  LWIIGVLTLTGIAVGLVIRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVS 116
           L+  G +T+  +  G            + +  P +        +     A ++ L+ G +
Sbjct: 289 LYGEGYITIKNLLGGNYTTLLSNSIFAEYSSLPWVIILFTVVTVFAKSAATLITLSAGGN 348

Query: 117 LGPEHPIMTVNIALAVAIG----ARLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQ 172
            G   P + +   +  A+        L  ++   + +   A ++ A+   P+    + ++
Sbjct: 349 GGIFAPSLIMGGLIGFAVAFAINTLGLAHLSVANFIVAGMAASLSAIMHAPLTGIFLIAE 408

Query: 173 TLNGSSEVPLWDRLFAPLMAAAAGALTTG 201
              G      +  +   ++ +A   L   
Sbjct: 409 ITGG------YVLMVPLMITSAIAYLINR 431


>UniRef50_P73745 Sll0855 protein n=1 Tax=Synechocystis sp. PCC 6803
           RepID=P73745_SYNY3
          Length = 451

 Score =  191 bits (485), Expect = 5e-47,   Method: Composition-based stats.
 Identities = 61/417 (14%), Positives = 136/417 (32%), Gaps = 27/417 (6%)

Query: 2   LHPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIG 61
           LHPR        + A+ +G+ + ++        + +  L W+     +        W++ 
Sbjct: 27  LHPRT------LVAAIVVGLITGVLGAGFKSAVNNM--LQWRSQLAQILAPIPPLAWLVT 78

Query: 62  VLTLTGIAV---GLVIRFSQGHAGP-DPACEPLIGAPVPP---SALPGLIVALILGLAGG 114
            L   G+      L+ RF+   +G   P  E  +   +P      LP  +V   L L  G
Sbjct: 79  ALISGGMVALSFWLMKRFAPDTSGSGIPQIEGHLEGKLPLVWQRVLPIKLVGGFLSLGAG 138

Query: 115 VSLGPEHPIMTVNIALAVAIGARLLPR-VNRMEWTILASAGTIGALFGTPVAAALIFSQT 173
           +  G E P + +  ++    G        N+     + +   +   F  P+A   +  + 
Sbjct: 139 MLAGFEGPTIQMGGSIGQMTGGWFKATQENQRILIAVGAGAGLATAFNAPLAGVALIGEE 198

Query: 174 LNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIA 233
           ++            + L       +   +       + +  + ++ +  +    I+  + 
Sbjct: 199 MHPRFRSQTL-AYHSLLFGCVMATIILRMIRGQSAIISLTEFKRVPLDSLWMFIILGILF 257

Query: 234 IAAGMVAVWCLPRLHAMMHQMKNPV--LVLGIGGFILGILGVIGGPVSLFKGLDEMQQMV 291
              G      L ++     ++          + G I+GIL +   P  L  G D      
Sbjct: 258 GVMGYTFNRGLFKVLDWFDRLPPLATKWKGFLLGSIIGILSLFPLP--LTDGGDNAVLWA 315

Query: 292 ANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVP---- 347
            N     S   L+   +    ++   SG  GG   P + +   + + +  H   +     
Sbjct: 316 FNSQSHFSTLILVFCGRFLLTLICYGSGAIGGIFAPMLGIASIVSVAMARHFHLLFPSQI 375

Query: 348 --AAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKP 402
              A+     +  +V    R    ++ +   +  N  ++  L +  L A ++     
Sbjct: 376 PEPAVMAIAGMGALVAATVRAPLTAILLTIEMTDNYFVILPLLVTCLVASVVAEALG 432


>UniRef50_Q8XTT4 Putative chloride channel protein clcB-like n=62
           Tax=Burkholderiaceae RepID=CLCL_RALSO
          Length = 429

 Score =  191 bits (485), Expect = 5e-47,   Method: Composition-based stats.
 Identities = 69/408 (16%), Positives = 140/408 (34%), Gaps = 21/408 (5%)

Query: 12  LSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLW-IIGVLTLTGIAV 70
           +   A  IG A +L  I   +    LQ  L     G +  A+  P W  + V T  G+  
Sbjct: 1   MLAIAGLIGCAGALATIAFRECLRQLQWWLAGADQGLVATARALPWWARLLVPTAGGLLA 60

Query: 71  GLVIRFS-----QGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMT 125
           GL +++      +  A        +    +          + +  +A G S+G E P++ 
Sbjct: 61  GLTLQYGLKWIPRKGAEDYMEAIAVGDGVLSARQSLVRSASSLCSVASGASIGREGPMVQ 120

Query: 126 VNIALAVAIGARLLPR-----VNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEV 180
           +       +G  L         +        +A  I + +  P+A A+   + +      
Sbjct: 121 LAAMCGSLLGRVLRHAMPVSVEHMRLLVACGAAAGITSAYNAPIAGAVFVCEIV---FGA 177

Query: 181 PLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVA 240
                L   L++A    +    FF       + H+  +   ++L+   +   A  AG + 
Sbjct: 178 ITTATLGPLLVSAVTADIIVRQFFGYGAVYAMPHFDFVSGWEVLTYLGLGLAAGMAGPLL 237

Query: 241 VWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSD 300
           +  + R      + + P  +    G ++     I  P     G   +   + +  +    
Sbjct: 238 LGLIDRARGAFARTRLPQALRLALGGLIVGALSIRVPEVWGNGYSVVNGFL-HAPWLWQT 296

Query: 301 YFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAI------TVSC 354
             L+ V K+ A   +A SG  GG   P +F G ALGL+    + A+              
Sbjct: 297 VALVLVCKVGATAASAGSGAVGGVFTPTLFCGAALGLLYGTGMHALLPGAAPVPVSYAVV 356

Query: 355 AILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKP 402
            +  ++   T    +S+ M   +  +  ++  L +  +  ++      
Sbjct: 357 GMGALLAATTHAPLMSILMIFEMTLSYQVVLPLMLACITGYVTAHATG 404


>UniRef50_C1SJ13 Chloride channel protein EriC n=1 Tax=Denitrovibrio acetiphilus DSM
           12809 RepID=C1SJ13_9BACT
          Length = 440

 Score =  191 bits (485), Expect = 6e-47,   Method: Composition-based stats.
 Identities = 66/400 (16%), Positives = 146/400 (36%), Gaps = 17/400 (4%)

Query: 12  LSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTL--GIAQDSPLWIIGVLTLTGIA 69
           + L AV +G  +    I+   + S  QNL +      +   +       II V  + G+ 
Sbjct: 1   MVLIAVIVGACAGFGNIIFRYLISFFQNLFYGTKSEYVLEALNNTPFYKIILVPAIGGLM 60

Query: 70  VG---LVIRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTV 126
           VG   ++ +F++GH  PD      +   + P      + +  + L  G S G E PI+ +
Sbjct: 61  VGGISIMFKFAKGHGVPDVMKAIALNRSISPLIAVIKVFSSAITLGSGGSAGREGPIVQI 120

Query: 127 NIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDR 185
             A+   IG                 +AG + A F  P+  A+  ++ L G   +     
Sbjct: 121 GAAIGSGIGKVFSFSSARMKTVIACGAAGGLAATFNAPIGGAMFAAEVLLGEFGL---KT 177

Query: 186 LFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLP 245
               ++++    + +  +   H +     Y    + ++    ++  +    G++ +    
Sbjct: 178 FSPIIISSVIATVVSRAYLGDHVTFDAPEYVLHSIFELPLYTLLGMLCAVIGIIFIRVYY 237

Query: 246 RLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLA 305
           +      ++  P       G +L     +     +  G D +  ++++ A       LL 
Sbjct: 238 KFEEKFEELTIPSWSKPALGGLLMGCVALLSRDVMGVGYDTIDSILSHNA--GFMLILLV 295

Query: 306 VIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAI------TVSCAILGI 359
            +K+ A  +   SG  GG   P++++G A G      V  +   +          A+  +
Sbjct: 296 FLKIIATSLTLGSGGSGGLFVPSLYIGAATGGFFGWIVNLLFPTMTGGSGAYGLVAMSAM 355

Query: 360 VLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLA 399
           +    R    ++ +   +  + T++  L +  + A +   
Sbjct: 356 LAATIRAPLTAILIIFEITQSYTVILPLMLTAIVANIFAG 395


>UniRef50_Q72EW7 Chloride channel family protein n=6 Tax=Desulfovibrionales
           RepID=Q72EW7_DESVH
          Length = 603

 Score =  190 bits (484), Expect = 6e-47,   Method: Composition-based stats.
 Identities = 71/440 (16%), Positives = 133/440 (30%), Gaps = 36/440 (8%)

Query: 9   MLLLSLPAVAIGIASSLILIVVMKIASVLQNLLW--------------QRLPGTLGIAQD 54
            + L++  + +G+ S    ++        ++L+                           
Sbjct: 21  FVRLAVLGIGLGVVSGCAAMLFFLGIEYAKHLILVAWAGLSLPAPAGEGLFHDAAAGGAY 80

Query: 55  SPLWIIGVLTLTGIAVGLVIRF------SQGHAGPDPACEPLIGAP--VPPSALPGLIVA 106
            P  I      TG+  G +++       +    G D            +   A     + 
Sbjct: 81  RPWVIPLATCATGLVTGWLVQRFLPDSLAGMTDGTDAMIRAFHRGKGVIRKRAPFIKGLT 140

Query: 107 LILGLAGGVSLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVA 165
            IL +A G S G E PI  +   L   +  RL L    R    +  +AG +GA+F  P+ 
Sbjct: 141 SILTIASGGSAGREGPISQIGAGLGSFVADRLHLSTKERRLLMLAGAAGGLGAVFRAPLG 200

Query: 166 AALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILS 225
            AL   + +         + +   ++++          F       I  +   +M ++  
Sbjct: 201 GALTAIEVVYREDFEA--EAMLPAILSSVVAYTLFAYVFGTEPMFAIPRFSFSDMRELPF 258

Query: 226 GAIVAAIAIAAGMVAVWCLPRLH---AMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFK 282
              +A      G   V     +     +    +  ++     G +L  L  I     L  
Sbjct: 259 YLTLALACAFTGWAYVRTFRFMKYGVFLRLAERVGIMWTTALGGLLVGLFGIIYTPMLSD 318

Query: 283 GLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVF----VGVALGLM 338
           G   ++Q +     + +    + V K  A  +   SG  GG   PA+F     G  +G  
Sbjct: 319 GYGWVEQAILG-HLTVTTMVTIMVAKTLATAMTLGSGMSGGMFAPALFVGGMTGGVVGYA 377

Query: 339 LHEHVPAV--PAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWL 396
            H+  P +       V   +      V       L M   +     LL  L +      L
Sbjct: 378 AHDLFPHIVREPGGYVLVGMAAFFAGVAHAPVGPLIMVCELTQGYGLLAPLMLASAVCIL 437

Query: 397 LLAGKPMMMVNRPKQ-QPPH 415
           L     +       + + P 
Sbjct: 438 LNRKVSLYENQVENKFESPA 457


>UniRef50_B0S0E6 Chloride channel protein n=2 Tax=Finegoldia magna
           RepID=B0S0E6_FINM2
          Length = 512

 Score =  190 bits (483), Expect = 8e-47,   Method: Composition-based stats.
 Identities = 66/405 (16%), Positives = 139/405 (34%), Gaps = 17/405 (4%)

Query: 8   TMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTG 67
           + + L L +++IG+ S  + +    + S L+ +           +    + II V  + G
Sbjct: 9   SSMSLFLASLSIGVFSGGLAVFYRFLLSKLEVVRNTIYSNN---SFPRAILIIAVSFVLG 65

Query: 68  IAVGLVIRFSQGHAGP-DPACEPLIGAPVP---PSALPGLIVALILGLAGGVSLGPEHPI 123
           I V  +++++    G   P  +  +               IV   +    G+SLG E P 
Sbjct: 66  ICVSKLLKWAPLSGGSGIPQVQGELIGAFNQNSFRVTVSKIVGGAIASLVGLSLGREGPS 125

Query: 124 MTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPL 182
           + +  + A  +  +    +     +    +A  + A F  P++  +   + L+ S    +
Sbjct: 126 IQLGASSAKWLSEKFGKSKTEEKLYLTAGAAAGLSAAFSAPISGLVFILEELHKSFSKKV 185

Query: 183 WDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVW 242
               F+   AA    +     F             +     L    +  I    G +   
Sbjct: 186 VAISFS---AAVIADVIAVWVFKIKPVFSFGMTHVLPTKYYLLIFPMIIICSVVGKLFNC 242

Query: 243 CLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYF 302
            +     +  ++K    +     F    +  +     L  G   ++ M  +   S     
Sbjct: 243 SITFFQDIFAKIKLEQDIKIAIFFAFVSVVGLFYKDILGGGHSFIENMATHNYNSFFVLI 302

Query: 303 LLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPA------VPAAITVSCAI 356
           +L + K+     + A+G +GG   P + +G   GL     + A      V  +  V  A+
Sbjct: 303 ILLLFKMFMTSTSYATGTQGGIFLPVLVLGGITGLFYFNLMSAFGFVQDVYLSNFVVLAM 362

Query: 357 LGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGK 401
           + ++  V R   LS+ +   +  N T L  L    + A+ +    
Sbjct: 363 VCVLTAVVRSPLLSVVLVLELNGNMTHLLGLAFCSIMAYFICKAL 407


>UniRef50_A9SXI1 Predicted protein n=1 Tax=Physcomitrella patens subsp. patens
           RepID=A9SXI1_PHYPA
          Length = 740

 Score =  189 bits (481), Expect = 1e-46,   Method: Composition-based stats.
 Identities = 57/425 (13%), Positives = 130/425 (30%), Gaps = 65/425 (15%)

Query: 11  LLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLP--GTLGIAQDS----PLWIIGVLT 64
           ++ L A  +G+ +   +++       + + +W+ +P  G   +         L ++ V  
Sbjct: 143 VIVLLACLVGVLTGGSVVLFNLAVHGIHDEVWEGIPVSGAAWLRTRPLKETWLRLLAVPF 202

Query: 65  LTGIAVGLVIRFSQ---GHAGPDPACEPLIGAPVPPS---ALPGLIVALILGLAGGVSLG 118
             G+ VG++    Q                                V+  + L  G SLG
Sbjct: 203 GGGVLVGILNTMRQTLDDDENEKSKSRSKSSRLADFRGVFRAFLKAVSAAVTLGTGCSLG 262

Query: 119 PEHPIMTVNIALAVAIGARLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSS 178
           PE P + +  ++A                            F   VA      +++    
Sbjct: 263 PEGPSVEIGASIANG--------------------------FNAAVAGCFFAVESVLRPL 296

Query: 179 EVPLWDRLFAP--LMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAA 236
                  L     L+++   ++ +        +  I  Y      ++    ++  ++   
Sbjct: 297 SSDSAPSLTTAMLLLSSVVASVISQAGLGSDPAFKIPAYDFRSPAELPLYLLLGILSGGV 356

Query: 237 GMVAVWCLPRLHAMMHQMKN----PVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVA 292
            +  V            +K     P   L   G +   +  +  P  L+ G + +  ++ 
Sbjct: 357 SVTLVKGSAYATTFFENVKKTTGIPAGFLPPVGGLAVGVIALAYPEILYWGFENVDVLLE 416

Query: 293 NQAF----STSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVP- 347
           ++ +    S      L  +K+ A  +   SG  GG   P++F+G ALG         +  
Sbjct: 417 SRPWARGPSVELLLQLVGVKVIATSLCRGSGLVGGMYAPSLFIGAALGSAYGNIARTLFS 476

Query: 348 ---------------AAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLC-IVM 391
                                  +  ++  V +    S+ +   +  +  ++  L   V 
Sbjct: 477 HVDPALHLEWIKVAAPQAYALVGMAAMLAGVCQVPLTSVLLLFELTRDYRIILPLMGAVG 536

Query: 392 LPAWL 396
           L +W+
Sbjct: 537 LSSWI 541


>UniRef50_B5FF64 Chloride channel protein n=4 Tax=Bacteria RepID=B5FF64_VIBFM
          Length = 459

 Score =  189 bits (481), Expect = 2e-46,   Method: Composition-based stats.
 Identities = 60/403 (14%), Positives = 122/403 (30%), Gaps = 22/403 (5%)

Query: 24  SLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRFSQGHAGP 83
           SL+++ V  +           L         +P  I  +       V     + +  AG 
Sbjct: 19  SLLILPVTLLVGSFNAFFLWLLSEATQARIANPWLIYLLPVAGLAIVYSYRNWGKNSAGG 78

Query: 84  ---DPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARLLP 140
                      G  VP    P ++   ++    G S G E   + +  A    +      
Sbjct: 79  NNLIMDEIHQAGEGVPVRMGPLVLFTTVITHLFGGSAGREGTAVQIGGATTDWLSKVFKL 138

Query: 141 RV-NRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALT 199
              +R        A    ++FGTP   A+   + L        ++ +   L+AA    + 
Sbjct: 139 SEDDRKMMLTAGVAAGFASIFGTPFTGAIFALEVLF--IGRIKFNAIIPALLAAILANVV 196

Query: 200 TGLFFHPHFSLPI---------AHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAM 250
              +   H    I          H   +++  +    I A     AG +          +
Sbjct: 197 ASAWGAHHTHYLINFDQVSTLFGHAVDIDLLLMAKVIIAAIGFGIAGYLFGELTHGFKDL 256

Query: 251 MHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDY-----FLLA 305
            +       ++ + G ++ I+         + G+          + +++       +   
Sbjct: 257 FNATLKNPYLIVVVGGLMVIIITQLLGNYDYIGIGVYPSRDGGVSITSAFTEGGAEWYSW 316

Query: 306 VIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLVVTR 365
           ++KL    +  A+G++GG + P  FVG  LG  L   +   P  +  +   L +    T 
Sbjct: 317 ILKLVLTAITLAAGYKGGEVTPLFFVGATLGNFLGWVM-GAPVDLFAALGFLAVFAAATN 375

Query: 366 DGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNR 408
                  M   +  +   LP   +    A+       +    R
Sbjct: 376 TPLACTIMGVELFGS-EYLPYFALACYTAYYFSGHTGIYSSQR 417


>UniRef50_B9Z484 Chloride channel core protein n=1 Tax=Lutiella nitroferrum 2002
           RepID=B9Z484_9NEIS
          Length = 601

 Score =  189 bits (480), Expect = 2e-46,   Method: Composition-based stats.
 Identities = 69/401 (17%), Positives = 139/401 (34%), Gaps = 16/401 (3%)

Query: 13  SLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGI-AQDSPLWIIGVLTLTGIAVG 71
            L AV IG+ ++ +  +      V   +L+        I AQ    W + V  L G   G
Sbjct: 51  LLLAVPIGMLAAGVTSLFRHAIDVGDRVLFGSAQDITVIMAQLDWRWRLFVPALGGGLAG 110

Query: 72  LVIRFSQG----HAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVN 127
           L++ ++Q       G            +P        ++ +  +    S+G E  ++ + 
Sbjct: 111 LILWYAQRKHGASHGEYMDAVSDGNGRLPLWPSLLRSLSSLASIVSAGSIGREGAMVQLA 170

Query: 128 IALAVAIGARLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLF 187
                  G R          T   +A  + +++ TP+A A+  ++ + G+  V L   L 
Sbjct: 171 AVTGSLTGRRWANERQLRLMTACGAAAGLASVYHTPLAGAMFVAEIVLGALTVDL---LV 227

Query: 188 APLMAAAAGALTTGLFFHPHFSLPIAH-YGQMEMTDILSGAIVAAIAIAAGMVAVWCLPR 246
               +A   +LT   F H      +A       +   L    +  +A     + +  L  
Sbjct: 228 PLFASAVTASLTILAFGHHDAPFALASGVAVPSLGVYLLILPIGLLAGLLAPLFLLVLDN 287

Query: 247 LHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAV 306
                 Q+   +      G +L     +  P     G   +  ++  +  S    + L +
Sbjct: 288 SKQAFRQLTLSMPWKMALGGLLMGAIAVFIPEVCGNGYAPIIDILQGRPLSEPVPWAL-L 346

Query: 307 IKLAALVVAAASGFRGGRIFPAVFV------GVALGLMLHEHVPAVPAAITVSCAILGIV 360
            K+AA  +   SG  GG   P++F+       VA  + ++  +P     +     +   +
Sbjct: 347 AKIAATALIVGSGAVGGIFTPSLFIGAALGAIVAAAVAMYPVLPQGDGTLIALIGMGAFM 406

Query: 361 LVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGK 401
             V+    +++ M   +  N  LL  L    + A+ +    
Sbjct: 407 AAVSHAPLMAVLMVFEMTMNAGLLLPLMAGSILAYAVSRKI 447


>UniRef50_Q15SM8 Cl-channel, voltage gated n=1 Tax=Pseudoalteromonas atlantica T6c
           RepID=Q15SM8_PSEA6
          Length = 544

 Score =  189 bits (480), Expect = 2e-46,   Method: Composition-based stats.
 Identities = 69/402 (17%), Positives = 135/402 (33%), Gaps = 20/402 (4%)

Query: 14  LPAVAIGIASSLILIVVMKIASVLQNLL------WQRLPGTLGIAQDSPLWIIGVLTLTG 67
           + +  +G+  ++  +  + +  V           +               W+  V TL G
Sbjct: 3   IWSFGLGVVGAIGALGFIWLLQVCSEFFIVGIGEFDETQPLTFPFLMPLYWVPVVTTLGG 62

Query: 68  IAVG-LVIRFSQGHAGP----DPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHP 122
           +  G +V R +    G                +         +A  + +  G S G E P
Sbjct: 63  LISGVIVYRLAPEAEGHGTDAYIEAFHQHDGAIRSRVPWVKALASAITIGSGGSAGREGP 122

Query: 123 IMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVP 181
              +   +A  +  R  L    R   T++A+A  + A+F +P+ +AL   + L     + 
Sbjct: 123 TAQICAGIAAILADRFGLANAERRLLTVVATAAGLSAIFKSPLGSALFAVKVLYSGFSME 182

Query: 182 LWDRLFAPLMAAAAGALTTGLFFHPHFSLPI-AHYGQMEMTDILSGAIVAAIAIAAGMVA 240
               L+  ++A+A      G          I A        ++     +   +     + 
Sbjct: 183 T-RALYFAILASATAYTIMGFVVGWSPIFNIQAALSLTHPMELSWYVGLGIASGIVASII 241

Query: 241 VWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSD 300
                 +  +   +  P  +    G +L  L  +  P  L  G   ++  + +Q   T  
Sbjct: 242 PTIFYTIRDLFRLINIPHFIKPAIGGLLLGLIAMWIPQILGGGYQWIELAINHQLSLTVL 301

Query: 301 YFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPA-----AITVSCA 355
             LL +    A+ +   SG  GG   P +F+G  LG +  E   AV +     A  V   
Sbjct: 302 LVLLLLK-PLAMALTIGSGGSGGIFAPTLFIGAMLGAVFAELAGAVDSLSPSYASCVIIG 360

Query: 356 ILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLL 397
           +L +     R    SL M   +     L+    + ++ + L+
Sbjct: 361 MLALFGAAARTPLASLVMIMEMTGEYGLVAPAAVTVVISALV 402


>UniRef50_B7G8L3 Predicted protein n=1 Tax=Phaeodactylum tricornutum CCAP 1055/1
           RepID=B7G8L3_PHATR
          Length = 649

 Score =  188 bits (478), Expect = 4e-46,   Method: Composition-based stats.
 Identities = 74/495 (14%), Positives = 137/495 (27%), Gaps = 89/495 (17%)

Query: 5   RARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQ----RLPGTLGIAQDSPLWII 60
           R R+       A  +G+A+ + + V       ++ + +      LP    +        +
Sbjct: 121 RFRSSAFYLAEAALVGVATGISVAVFKLSIEFIREVCYNQSFLYLPAVRSVVPAVGGVAV 180

Query: 61  GVLTLTGIAVGLVIRFSQGHAGPDPACEPLIGAPVPPSA---------LPGLIVALILGL 111
           G+L   G        F  G  G     +      +                   A +  L
Sbjct: 181 GILYWAGRGA-----FPPGLRGTVQLVDQQDRRGLTVDTTQKVKTQIDFLRKSTAAVFTL 235

Query: 112 AGGVSLGPEHPIMTVNIALAVAIGA----RLLPRVNRME--WTILASAGTIGALFGTPVA 165
             G SLGPE P + + + +A          L               +A  + A F  P+A
Sbjct: 236 GTGCSLGPEGPCVEIGMNVARGCMDVKPEFLSRPRPHWNVCLLNCGAAAGVAAGFNAPLA 295

Query: 166 AALIFSQTLNG-------------------------SSEVPLWDRLFAPLMAAAAGALTT 200
                 + +                           S+ V   + +   L+A+   AL  
Sbjct: 296 GVFFTLEVMQSALNGVRQEEQEKQTLQGNNSDLNAASNAVSATENITPILLASVLSALVA 355

Query: 201 GLFFHPHFSLPIAHYGQMEMTDILSGAIV-AAIAIAAGMVAVWCLPRLHAMMH------- 252
                    L ++ Y        L   ++   I+               A          
Sbjct: 356 RTILGDTLVLSLSEYSLETPLIELPLYLLLGVISGFVAFSFSKAANWSQAFFSGEVGGES 415

Query: 253 ----QMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIK 308
                   P  V  + G     L  +  P  LF G + +  ++AN +  TS  F L ++K
Sbjct: 416 IQSFMSCLPEPVKPVIGGFACGLVGLVFPQILFFGYETLNSLLANASLPTSLLFSLLIVK 475

Query: 309 LAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAI------------------ 350
                V+A SG  GG   P++F+G  +G   H     V   +                  
Sbjct: 476 TIMTAVSAGSGLVGGTFAPSLFLGAMVGAAFHNVATIVFQTLMTSFPWESVGVLSSTAAP 535

Query: 351 ---------TVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGK 401
                            ++  + R    +  +   +  +  ++  L        L+    
Sbjct: 536 VLVLADVPAYAMVGAASVLAALFRAPLTASLLLFELTRDYDVILPLMASAGVGSLV-GDI 594

Query: 402 PMMMVNRPKQQPPHD 416
               V   ++ PP +
Sbjct: 595 LEDKVQNARRTPPPN 609


>UniRef50_B7CDF1 Putative uncharacterized protein n=1 Tax=Eubacterium biforme DSM
           3989 RepID=B7CDF1_9FIRM
          Length = 406

 Score =  188 bits (478), Expect = 4e-46,   Method: Composition-based stats.
 Identities = 57/404 (14%), Positives = 137/404 (33%), Gaps = 21/404 (5%)

Query: 13  SLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGL 72
               + IG   ++  +V  K    + N             +     ++  L   G+A+  
Sbjct: 20  CFCGIFIGAIVAICEVVFGKGLEWILNF-----------REHMGCVMLVGLPFAGLAIVF 68

Query: 73  VI----RFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNI 128
           +     R S+   G     +      +P    P ++V+  +    G S G E   M +  
Sbjct: 69  LFDHWGRISRKGMGLVFEVDQGKSDWIPLRMAPFMVVSTWITHFFGGSAGREGVAMQIGA 128

Query: 129 ALAVAIGARLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFA 188
            ++   G     + + + + +   A     LFGTP+ A     + L   +    +  +  
Sbjct: 129 TVSHYFGKYFRFKNSGVIFMVAGMAAGFAGLFGTPITAIFFALEVLV--AGTLKYRAMSC 186

Query: 189 PLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLH 248
            + A+   A  +GLF     +  I +  ++ M   +   ++  +    G +  + L    
Sbjct: 187 AIPASFTAAYVSGLFGLHKSTFKIGNVAELNMELSIKLLVLGILFGMVGGLFAYFLKHTK 246

Query: 249 AMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIK 308
           A +               I+  + +       + G+   + ++     S   Y    ++K
Sbjct: 247 AFVTNKITNPYKRIFMMGIIVAILLFVFGKCRYSGVG--ENLIVGSFTSEKIYSYDWILK 304

Query: 309 LAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLVVTRDGW 368
               ++  ++GF+GG + P   +G +LG+++      +      S     +    T    
Sbjct: 305 FILTILTLSAGFQGGEVTPLFAIGSSLGVIIAPVF-GLNPLFVASLGYCSVFGAATNTFL 363

Query: 369 LSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNRPKQQ 412
             + +   V       P   +V   ++++   + +  + R  ++
Sbjct: 364 APIAIGMEVFG-YQYFPFFFVVCAISYIVNQNESIYALQRQVRE 406



 Score = 41.3 bits (96), Expect = 0.075,   Method: Composition-based stats.
 Identities = 19/186 (10%), Positives = 54/186 (29%), Gaps = 7/186 (3%)

Query: 222 DILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLF 281
           +I+          A   +      +    +   +  +  + + G     L ++       
Sbjct: 15  EIVLKCFCGIFIGAIVAICEVVFGKGLEWILNFREHMGCVMLVGLPFAGLAIVFLFDHWG 74

Query: 282 K----GLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGL 337
           +    G+  + ++   ++          ++   +  +    G   GR   A+ +G  +  
Sbjct: 75  RISRKGMGLVFEVDQGKSDWIPLRMAPFMV--VSTWITHFFGGSAGREGVAMQIGATVSH 132

Query: 338 MLHEHVPAVPAA-ITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWL 396
              ++     +  I +   +      +      ++F A  V+   TL        +PA  
Sbjct: 133 YFGKYFRFKNSGVIFMVAGMAAGFAGLFGTPITAIFFALEVLVAGTLKYRAMSCAIPASF 192

Query: 397 LLAGKP 402
             A   
Sbjct: 193 TAAYVS 198


>UniRef50_B2V3B5 Voltage gated chloride channel family n=9 Tax=Clostridiales
           RepID=B2V3B5_CLOBA
          Length = 418

 Score =  188 bits (478), Expect = 4e-46,   Method: Composition-based stats.
 Identities = 58/407 (14%), Positives = 136/407 (33%), Gaps = 27/407 (6%)

Query: 8   TMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTG 67
           T  L  + A   G+    I  +         +   +              WII +L L G
Sbjct: 17  TFFLWVVVAGITGLIGGFIGSLFHLSVEYATSFRIEND------------WIIFMLPLGG 64

Query: 68  IAVGLVIRFSQ---GHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIM 124
             +  + +  +                   VP S  P + ++ ++    G S G E   +
Sbjct: 65  ALIICLYKILKLGSNIGTNLVIDSIRTDGKVPFSMSPLIFISTVITHLFGGSAGREGAAL 124

Query: 125 TVNIALAVAIGARLLPRVNRMEWT-ILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLW 183
            +  ++   +G  L      M    +   +G   ALFGTP+ A     + +  S  +  +
Sbjct: 125 QLGGSIGSQVGKILHLDEKDMHLITLCGMSGVFSALFGTPLTATFFAMEVI--SVGIIYY 182

Query: 184 DRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWC 243
                 ++++      + LF        I     +   +I+  AI+ A+     ++    
Sbjct: 183 SSFIPCIVSSIVAYKVSLLFGLEPVRFNINVIPNISTENIIKVAILGALCALVSIIFCET 242

Query: 244 LPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGP--VSLFKGLDEMQQMVANQAFSTSDY 301
           L + +  +  +     +  I G +  +              G++ +   +  QA      
Sbjct: 243 LHKTNKFLSNLIKNDYLRIICGGLAIVALTFIVGSRDYNGAGMNIIANAINGQAKPE--- 299

Query: 302 FLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVL 361
               ++K+    +  + G++GG I P  F+G   G ++   +  +   +  +  ++ +  
Sbjct: 300 --AFILKIIFTAITISVGYKGGEIVPTFFIGATFGCVVGGLI-GLDPRLGAAIGLVALFC 356

Query: 362 VVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNR 408
            V      S+ ++  +  +   L L  +    +++L     +    +
Sbjct: 357 GVVNTLITSVILSIELFGS-GALILFAVACGVSYMLSGYFSLYSSQK 402



 Score = 50.6 bits (120), Expect = 1e-04,   Method: Composition-based stats.
 Identities = 18/189 (9%), Positives = 58/189 (30%), Gaps = 3/189 (1%)

Query: 223 ILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFK 282
            L   +     +  G +       +            ++ +      ++  +   + L  
Sbjct: 19  FLWVVVAGITGLIGGFIGSLFHLSVEYATSFRIENDWIIFMLPLGGALIICLYKILKLGS 78

Query: 283 GLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEH 342
            +     ++ +        F ++ +   + V+    G   GR   A+ +G ++G  + + 
Sbjct: 79  NIGT-NLVIDSIRTDGKVPFSMSPLIFISTVITHLFGGSAGREGAALQLGGSIGSQVGKI 137

Query: 343 VPAV--PAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAG 400
           +        +   C + G+   +      + F A  V+    +     I  + + ++   
Sbjct: 138 LHLDEKDMHLITLCGMSGVFSALFGTPLTATFFAMEVISVGIIYYSSFIPCIVSSIVAYK 197

Query: 401 KPMMMVNRP 409
             ++    P
Sbjct: 198 VSLLFGLEP 206


>UniRef50_Q874K8 Voltage-gated chloride channel n=3 Tax=Filobasidiella neoformans
           RepID=Q874K8_CRYNV
          Length = 864

 Score =  188 bits (478), Expect = 4e-46,   Method: Composition-based stats.
 Identities = 55/458 (12%), Positives = 126/458 (27%), Gaps = 73/458 (15%)

Query: 18  AIGIASSLILIVVMKIASVLQNLLWQRLPGTLGI-------------------------- 51
            +G+   +   ++  I + L ++          +                          
Sbjct: 106 LVGVIIGVSAALISIITTWLSDIKLGHCTTGWWLSRKFCCLEVSDELEACAEWKNWGGVE 165

Query: 52  AQDSPLWIIGVLTLTGIAVGLVIRFSQGHAGPDPACEP------LIGAPVPPSALPGLIV 105
                 +++     +  A  LV  F+   AG   +         +I   +         +
Sbjct: 166 PFRWIAYVLFAAAFSFSAAYLVKNFAPYAAGSGISEIKCILGGFIINGFLSVETFFIKGL 225

Query: 106 ALILGLAGGVSLGPEHPIMTVNIALAVAIGARL----LPRVNRMEWTILASAGTIGALFG 161
            L L +A G+++G E P + V  ++   +           +   E    +SA  +   FG
Sbjct: 226 TLPLAIASGLAVGKEGPSVHVACSVGNVVAKWFNRYERSHLKMREIVTASSAAGVAVAFG 285

Query: 162 TPVAAALIFSQTLNGSSE-VPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEM 220
           +P+   L   + +N +     +W      L+A    A              +++      
Sbjct: 286 SPIGGVLFSIEEMNQTYSNRTMWRSFVCALVATFTLASMDPFRTGKLVIFNVSYDRDWHY 345

Query: 221 TDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQ--MKNPVLVLGIGGFILGILGVI---- 274
            +I +  ++       G   +    ++ A   +    + +        I  I+G +    
Sbjct: 346 FEIPAYVLIGIFGGLYGAFVIKFNVQMAAFRRKHLSGHGIFEAVALASITAIIGYLNGFL 405

Query: 275 ----------GGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGR 324
                             G        ++Q    +   L  +I+   ++V+       G 
Sbjct: 406 RIDMTEMLSVLFRECEGGGDYNGLCQASSQWRMVNSLLLATIIRTVFIIVSYGCKVPAGI 465

Query: 325 IFPAVFVGVALGLMLHEHV--------------------PAVPAAITVSCAILGIVLVVT 364
             P++ VG   G M+   V                    P +             +  +T
Sbjct: 466 FVPSMAVGATFGRMIGILVKAMYNSYPSAPWFAACAPDAPCITPGTYAFLGAAAAMGGIT 525

Query: 365 RDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKP 402
           R     + +   +    T +    IV+L    +     
Sbjct: 526 RLTVTVVVIMFELTGALTYILPTMIVLLVTKAVSDQFG 563


>UniRef50_A3DHF3 Cl-channel, voltage gated n=5 Tax=Clostridium RepID=A3DHF3_CLOTH
          Length = 435

 Score =  188 bits (477), Expect = 4e-46,   Method: Composition-based stats.
 Identities = 65/411 (15%), Positives = 141/411 (34%), Gaps = 26/411 (6%)

Query: 7   RTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLT 66
           R   ++ + A+ +G  +  I  V       + +              +  L+++  L + 
Sbjct: 12  RNQFIMCIAAIPLGAVTGAICAVFGLTLLKITDY-----------RTNHYLYLLPFLGIA 60

Query: 67  GIAVGLVIRFSQGHAGPDPACEPLIGAP----VPPSALPGLIVALILGLAGGVSLGPEHP 122
           G+ +          +    A    I       +P   +P  + +  L    G S G E  
Sbjct: 61  GVFITWCYNRFGNDSAKGMALLFEIHQDKRSSIPLRLIPFAVGSTWLTHLFGGSAGREGV 120

Query: 123 IMTVNIALAVAIGARLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPL 182
              +   L   IG ++          I   A     LF TP+AA     + L+    V  
Sbjct: 121 ATQIGGTLGSYIGNKIRVSGANKILMISGMAAGFSGLFHTPLAAVFFALEVLH--CGVIE 178

Query: 183 WDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVW 242
           +  L    ++A   +  + +      +  +        + I+   ++  +    GM+   
Sbjct: 179 YSALLPSFVSAYTASCISEILGLQKSTYFLDCRIVPSFSFIMKIIVLGVLFGLTGMLFSI 238

Query: 243 CLPRLHAMM-HQMKNPVLVLGIGG-FILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSD 300
            L +L A++ + +KN ++ + + G  I  I  +         G + +    +N       
Sbjct: 239 LLKKLRALLTNYIKNNIIRIFVFGTIIGIISIICFQGRYSGPGTNLISACFSNDIMPWDF 298

Query: 301 YFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIV 360
                  K+    +  A+G+ GG + P   +G + G +L   +  +P  + V+     + 
Sbjct: 299 ML-----KILFTALTLAAGYYGGEVVPLFSIGASAGFVLANVL-GLPIELCVALGYAAVF 352

Query: 361 LVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNRPKQ 411
              T   +  LF++  +   T  LP+   V   A++      +  +  P +
Sbjct: 353 GSATNTFFAPLFISTEIFG-TEYLPVFAAVCAIAYMFNGNNSIYPLQIPHE 402


>UniRef50_B5YBN2 SycA n=1 Tax=Dictyoglomus thermophilum H-6-12 RepID=B5YBN2_DICT6
          Length = 426

 Score =  188 bits (477), Expect = 5e-46,   Method: Composition-based stats.
 Identities = 56/345 (16%), Positives = 118/345 (34%), Gaps = 13/345 (3%)

Query: 41  LWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRFSQGHAGP----DPACEPLIGAPVP 96
             + L  ++ +      + I +     I   ++ + +    G                + 
Sbjct: 36  FLKLLHASINLTSKFEYYYILLPFALFITALIIEKIAPEAKGHGTEKVIESIHKRNGKIN 95

Query: 97  PSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARLLP-RVNRMEWTILASAGT 155
           P  +P  ++  I+ L+ G S G E P   +   LA            NR +  I   +  
Sbjct: 96  PLVVPIKLIGTIITLSAGGSAGKEGPSAQIGAGLASIFADIFKLDDRNRKKLVICGISAG 155

Query: 156 IGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHY 215
             ++FGTP+A A+   + L        ++ L    +A       +      +   P++  
Sbjct: 156 FASVFGTPIAGAIFGIEVLI--VGNMFYEALLPSFIAGIVSFQVSSKLGISYSYHPLSFN 213

Query: 216 GQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGF-ILGILGVI 274
                       I         ++ +  L     +  ++K    V G+ G  IL +L +I
Sbjct: 214 YSFNELHFAEAIIAGIFLGLVSIIFIETLNFFEDIYKKLKIWNPVKGLIGGSILVLLTLI 273

Query: 275 GGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVA 334
                L  G+D +++ +  +  +        ++K+   ++  + G  GG I P  F+G  
Sbjct: 274 FSKNFLGLGIDTIERALNGERIAW----YFFLVKIIFTIITLSFGGSGGIITPIFFIGST 329

Query: 335 LGLMLHEHVPAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVP 379
            G  L   +    A ++    ++ ++  VT     S  M   +  
Sbjct: 330 AGNFLANFLHFDRATLSAI-GMINLLASVTNTPIASSIMFIELFG 373


>UniRef50_Q31NT2 Chloride channel-like n=2 Tax=Synechococcus elongatus
           RepID=Q31NT2_SYNE7
          Length = 615

 Score =  187 bits (476), Expect = 5e-46,   Method: Composition-based stats.
 Identities = 68/396 (17%), Positives = 125/396 (31%), Gaps = 23/396 (5%)

Query: 23  SSLILIVVMKIASVLQNLLWQRLPGTL--GIAQDSPLWIIGVLTLTGIAVGLVIRFSQGH 80
           +   ++    +   L   ++  L  TL       +   I  +  L    + L+       
Sbjct: 44  TGAAIVGFHLLYESLHQGVFSWLSSTLSAWGGHQTLALIPLLGGLVMGGLILIWPRFGPS 103

Query: 81  AGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARLLP 140
                      G   P    P  + A  L LA G SLGPE P +     L +AI      
Sbjct: 104 MTGLIGLARGTGGDEPLRT-PQKLFAASLSLASGASLGPEGPSVESGGNLGLAIARWAKM 162

Query: 141 RVNRMEWTILASAGTIGAL-FGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALT 199
              R    I A A    A  F  P+A      + + G+S       + A L+AA   AL 
Sbjct: 163 SRERQLLLIGAGAAAGIAAGFNAPIAGVFFAFEVVLGTSFA--GAAVSAVLIAAVLSALV 220

Query: 200 TGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMH------- 252
             +      +  +  Y      ++     +  +A       +  +  L            
Sbjct: 221 AQVGLGAQPAFSLPDYVVRSPLELPLYLGLGVLASLVSSSYMALVQVLQQAFRGETAIGA 280

Query: 253 -QMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAA 311
              + P  +      ++  L  +  P  L  G + ++ +++  + +     LL + KL  
Sbjct: 281 VLGRIPRSLRPALAGLIVGLVALQFPQVLGVGYETIEGLLSGMSLTPLTLVLLLIGKLGL 340

Query: 312 LVVAAASGFRGGRIFPAVFVGVALGLMLH---------EHVPAVPAAITVSCAILGIVLV 362
             +  ASGF GG   PA+F+G  LG               +P           +  ++  
Sbjct: 341 TALCLASGFVGGGFAPAMFLGAVLGSFYGWVLTAFFPTSWIPIASPPAYAMVGMAAVLAG 400

Query: 363 VTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL 398
             R    ++ +   +  +  ++  L      +  L 
Sbjct: 401 SVRAPLTAILLLFELTRDYRIVLPLMAAAGLSAWLA 436


>UniRef50_Q0BQZ9 Chloride channel protein n=4 Tax=Acetobacteraceae
           RepID=Q0BQZ9_GRABC
          Length = 479

 Score =  187 bits (476), Expect = 6e-46,   Method: Composition-based stats.
 Identities = 82/398 (20%), Positives = 145/398 (36%), Gaps = 30/398 (7%)

Query: 21  IASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIR---FS 77
           +A SL  I   K+A   Q++                 WII +L   G+ V  ++    F 
Sbjct: 59  VAVSLTAIAFAKLADRAQDVF--------SAVIAHGAWIILILAPCGLVVSFLLARHVFP 110

Query: 78  QGHAGPDPACEP--------LIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIA 129
                  P             +   +      G I+  +LGLA G S+G E P + V  +
Sbjct: 111 GSQGSGIPQVIASLDLADVRQVDRILSLRIAVGKILLTLLGLASGASIGREGPTVQVGAS 170

Query: 130 LAVAIGARLLPRVN--RMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLF 187
           +  A+G  L       R    +   A  I A F TP+A  +   + L+ S E        
Sbjct: 171 VMHALGRLLHLPTPELRRSVVLAGGAAGIAAAFNTPLAGIVFAIEELSHSYEARTSGNTL 230

Query: 188 APLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRL 247
           A ++ +    +T  L  +  +   I    +   +++++  I A +    G      L R 
Sbjct: 231 AAVVISGV--VTIALVGNYSYFGHIDATMRFGPSEVMAMVICAVLGGLLGGSFSALLIRA 288

Query: 248 HAMMH------QMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDY 301
                        + PVL   + G I+ I G++    +   G ++ + MV      T   
Sbjct: 289 AKGFPGALGRLVKQYPVLFAALCGLIVAITGLLSHGETYGTGYEQARDMVTGLPGDTEGL 348

Query: 302 FLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVL 361
              A++KL A   +  SG  GG   P++ +G  LG  +   VP + A   V   ++    
Sbjct: 349 -KFALLKLVASAASYLSGIPGGIFAPSLAIGAGLGEWVARLVPGLAAGSVVLLGMVAYFS 407

Query: 362 VVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLA 399
            V +    +  +   +  N ++L  L    + A+ +  
Sbjct: 408 GVVQAPITAAVIVMEMADNQSMLIPLMATSMMAFAVSR 445



 Score = 49.0 bits (116), Expect = 3e-04,   Method: Composition-based stats.
 Identities = 26/198 (13%), Positives = 59/198 (29%), Gaps = 19/198 (9%)

Query: 10  LLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIA 69
           + + + AV  G+       ++++ A           PG LG        +   L    +A
Sbjct: 265 MAMVICAVLGGLLGGSFSALLIRAAK--------GFPGALGRLVKQYPVLFAALCGLIVA 316

Query: 70  VGLVIRFSQGHAGPDPACEPLIGAPV----PPSALPGLIVALILGLAGGVSLGPEHPIMT 125
           +  ++   + +         ++                +VA       G+  G   P + 
Sbjct: 317 ITGLLSHGETYGTGYEQARDMVTGLPGDTEGLKFALLKLVASAASYLSGIPGGIFAPSLA 376

Query: 126 VNIALAVAIGARLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDR 185
           +   L   +  RL+P +      +L        +   P+ AA+I  +  +          
Sbjct: 377 IGAGLGEWVA-RLVPGLAAGSVVLLGMVAYFSGVVQAPITAAVIVMEMADNQ------SM 429

Query: 186 LFAPLMAAAAGALTTGLF 203
           L   +  +      + L 
Sbjct: 430 LIPLMATSMMAFAVSRLV 447


>UniRef50_D1PN62 Chloride transporter, chloride channel family n=1
           Tax=Subdoligranulum variabile DSM 15176
           RepID=D1PN62_9FIRM
          Length = 429

 Score =  187 bits (476), Expect = 6e-46,   Method: Composition-based stats.
 Identities = 64/406 (15%), Positives = 137/406 (33%), Gaps = 25/406 (6%)

Query: 7   RTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLT 66
           R      + A  +G  +  +        S                 +D   W++ +L + 
Sbjct: 16  RVCAKWLVLAALVGCLTGPLGAAFGLALSWA------------NATRDVQGWLLYLLPVG 63

Query: 67  GIAVGLVIR-FSQGHAGPDPACEPLIGAP--VPPSALPGLIVALILGLAGGVSLGPEHPI 123
           G+ +  + R F     G        +     +     P +  + +     G S G E   
Sbjct: 64  GLVIVFLYRHFDPQGGGSTNQVFAAVRERKVLTLRTAPLIFFSTVTTHLLGGSSGREGAA 123

Query: 124 MTVNIALAVAIGARLL-PRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPL 182
           + +  +++   G  L   R +    T+   AG   A+FGTP+AA +   + +  +     
Sbjct: 124 LLLGGSVSGQFGRLLRLNRHDCRLMTMCGMAGAFSAIFGTPLAATVFTIEVV--NVGSMQ 181

Query: 183 WDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVW 242
           +  L   L++A  G   +G       +  +    ++    +    ++  +     +V   
Sbjct: 182 YAALLPCLVSALLGVWISGQLGVAPTAFTLGATAELNPITLAQVLVLGILLAGLSIVFCE 241

Query: 243 CLPRLHAMMHQM-KNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDY 301
            L     +  +   NP L + +GG ++  L  + G        +     V   A      
Sbjct: 242 LLHITPKLYTKFLPNPYLRVAVGGLLIIALTKLLG----TTDYNGAGSAVIAAAMVGQAL 297

Query: 302 FLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVL 361
                +K+    +   +G++GG I P  F G   G  +   +  +PA +  +  ++ +  
Sbjct: 298 PWAFALKMLFTALTLGAGYKGGEIVPIFFTGATFGCAVAPLL-GLPAPLGAALGMVALFC 356

Query: 362 VVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVN 407
             T     S+ +   V      LPL  +V   +++L +   +    
Sbjct: 357 GCTNSPLASICLGLEVFGG-QCLPLFALVCAVSYMLSSYFSLYHEQ 401


>UniRef50_C7TB40 Chloride channel protein n=53 Tax=Lactobacillales
           RepID=C7TB40_LACRG
          Length = 526

 Score =  187 bits (476), Expect = 6e-46,   Method: Composition-based stats.
 Identities = 69/410 (16%), Positives = 138/410 (33%), Gaps = 21/410 (5%)

Query: 22  ASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGV---LTLTGIAVGLVIRFSQ 78
            +  ++        V      Q              W + +   L L GI   L+ +   
Sbjct: 28  MTGTVVSAFRYCIEVGLRASRQVYGYLRVTPFVWWHWALLIGFNLVLAGIVAWLLKKEPY 87

Query: 79  GHAGPDPACEPLIGAPVP---PSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIG 135
                 P  E  +   +     S L    V  +L LA G+ LG E P + +  ++   + 
Sbjct: 88  ISGSGIPQVEGQLAGELEMNWWSILWRKFVGGVLALAPGLFLGREGPSIQLGASVGQGLA 147

Query: 136 ARLLPR-VNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAA 194
                R  +R       SA  + A F  P+A  L   + +  +    +W      L  A 
Sbjct: 148 GGFKLRGTDRRLLIASGSAAGLAAAFNAPIAGTLFVLEEVYHNFSPLVW---LTALAGAI 204

Query: 195 AGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQM 254
                +   F     L +++   + +T      ++  +    G +    L  +     ++
Sbjct: 205 GSDFISLNVFGLVPVLHLSYSRSLPVTSYWHLILLGILLGLLGYLYQRVLLAMPRWYQRL 264

Query: 255 KN-PVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALV 313
            + P  + G+  F+L +      P  L  G   +         S      + VI+    +
Sbjct: 265 THLPRAIQGVVPFVLLMAVGYFTPNLLGGGNSLIVG-FGQYVPSLLVLLGIFVIRFIFSM 323

Query: 314 VAAASGFRGGRIFPAVFVGVALGLMLH------EHVPAVPAAITVSCAILGIVLVVTRDG 367
           ++  SG  GG   P + +G  +G +          +P V     +  ++ G    + +  
Sbjct: 324 ISYGSGLPGGIFLPILSLGAVIGAVYGVVMNQLGLLPHVYIMNLIIFSMAGYFAGIGKAP 383

Query: 368 WLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL---AGKPMMMVNRPKQQPP 414
           + ++ +   +V N T L  L ++ L A+L++    G P+      +   P
Sbjct: 384 FTAILLVTEMVGNLTHLMPLAVLSLTAYLVVDLLGGAPIYEALLEQMTIP 433


>UniRef50_C5PV52 Chloride channel protein n=1 Tax=Sphingobacterium spiritivorum ATCC
           33861 RepID=C5PV52_9SPHI
          Length = 596

 Score =  187 bits (476), Expect = 7e-46,   Method: Composition-based stats.
 Identities = 65/418 (15%), Positives = 136/418 (32%), Gaps = 38/418 (9%)

Query: 12  LSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVG 71
           L + A  +GI   +   V       + + +   L   +        +++  L    ++V 
Sbjct: 26  LIILAFVVGIIGGIAASV----LKGMTHFIASALQDDVEWHYKYSFYLVFPLIGILLSVL 81

Query: 72  LVIRFSQG-----HAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTV 126
            + +F +G        P         + + P  +   I+   + +  G S G E PI   
Sbjct: 82  YIRKFLKGKNFEHGITPIIYSISRKSSRIEPHNVYSQIITSAVTVGFGGSSGLEAPIAYS 141

Query: 127 NIALAVAIGARLLPRVNRME-WTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDR 185
             A+   +G     +   +       +A  I   F +PVA  +   + L     +P    
Sbjct: 142 GSAIGSNVGRFFGLQYREITMLLACGAAAGISGAFNSPVAGMIFAIEILLPEFSIP---A 198

Query: 186 LFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLP 245
               L+++A  ++ + L +              E   +    I++ +     +       
Sbjct: 199 FIPLLISSALASVISRLLYSEPLFHTATS--DWEFKALFFYVIMSVLVGLYTVYFAKISA 256

Query: 246 RLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFST------- 298
            + +   ++KNP   +   G  LG + +   P    +G   +QQ++  +  S        
Sbjct: 257 IIKSWFSKIKNPYNKVWFSGISLG-VMIFIFPALYGEGYLTIQQLLDGRFDSIVKNSLFS 315

Query: 299 ----------SDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPA--- 345
                     +   L    K  A +     G  GG   P++ +G  LG      +     
Sbjct: 316 SYKDIGWVVVAYTVLTLFGKSFAALFTLNGGGNGGVFGPSLVMGGLLGFAFAYGMNLTGL 375

Query: 346 --VPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGK 401
             +     V   +   +  +      S+F+ A +    TL+  L +V   A+L+    
Sbjct: 376 VTLNIPNFVMAGMAAALAGIMHAPLTSIFLIAEITGGYTLMVPLMLVASIAYLINRAI 433


>UniRef50_B9WL45 Voltage-gated chloride channel, putative n=6 Tax=Saccharomycetales
           RepID=B9WL45_CANDC
          Length = 974

 Score =  187 bits (475), Expect = 8e-46,   Method: Composition-based stats.
 Identities = 43/407 (10%), Positives = 104/407 (25%), Gaps = 74/407 (18%)

Query: 81  AGPDPACEPLIGAPVPPS-----ALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIG 135
               P  + ++   V         L    VAL+  +A G+SLG E P + +   +     
Sbjct: 344 GSGVPEVKTILSGFVIRRFLGTYTLIAKTVALVFAIASGMSLGKEGPYVHLATCVGNITS 403

Query: 136 ARLLPRVN----RMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVP-LWDRLFAPL 190
                         +    +++  +   FG+P+   L   + +N       L+   F  +
Sbjct: 404 RFFPFIYENDFFEKQILSASASAGVALAFGSPLGGVLFILEEINNYLPSNQLFQIFFCAI 463

Query: 191 MAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAM 250
           ++                   + ++      +++   ++  +    G   +         
Sbjct: 464 ISTLFLKFLNPYGTGKTVLFELEYFSDWSPIELIFFVVIGIMGGVFGASFIKFSQWWAKK 523

Query: 251 MHQMKN----PVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFS--------- 297
               K+    P+  + +   + GI+     P +     + +  +    +           
Sbjct: 524 FRSSKHIKTHPIFEVFLVAAVTGII-SFWNPYTKQASAELVLDLATPCSGGELDRSLCPQ 582

Query: 298 --------TSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHV------ 343
                    +      V+K+    +        G   P++  G   G +    +      
Sbjct: 583 TEKQLINELTSLLFAFVVKVLLTFITFGLKLPCGIYVPSMVCGALFGRIFALFIRWLEFL 642

Query: 344 ---------------------------------PAVPAAITVSCAILGIVLVVTRDGWLS 370
                                              V   I    +    +  VTR     
Sbjct: 643 SRKSSSSSSSSLSLFAQPAPPLKFGLLCSSAGPHCVDMGIYAMISAGAFMAGVTRMNITL 702

Query: 371 LFMAAVVVPNTTLLPLLCIVMLPAWL---LLAGKPMMMVNRPKQQPP 414
           + +   +  + T +  + I +  A     LL    +          P
Sbjct: 703 VTILFELTSSYTYVLPISIAIAVANWSGGLLEKNSLYESLLISNDYP 749


>UniRef50_C2E3Z4 CPA2 family monovalent cation:proton (H+) antiporter-2 n=3
           Tax=Lactobacillus johnsonii RepID=C2E3Z4_LACJO
          Length = 450

 Score =  187 bits (475), Expect = 8e-46,   Method: Composition-based stats.
 Identities = 59/412 (14%), Positives = 134/412 (32%), Gaps = 29/412 (7%)

Query: 27  LIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRFSQGHAGP-DP 85
           + +   +     + L+   P      Q   L+ I    +  +   ++  +    +G   P
Sbjct: 40  VSIFRFVIDKSIHFLYFLYPYLAAHPQWISLYTIFTFFICILVSKIIKPYLLDLSGSGIP 99

Query: 86  ACEPLIGAPVP---PSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARLL--P 140
             E  +           L    V  +L  + G+ LG E P + +   +       +    
Sbjct: 100 QVEATLMGEHEVDWFPVLWRKFVGGLLVSSMGLFLGREGPCIQMGALVGQGFAENIFECS 159

Query: 141 RVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTT 200
             +R        A  + A    P+A      + +  S +        + L AAA+  L T
Sbjct: 160 EEDRRLLQCAGIAAGLSAAVSAPLAGVFFLVEVITHSFKPKE---CISALGAAASADLVT 216

Query: 201 GLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMK-NPVL 259
            +FF     L +    ++ +    S   V  +A          L     + +++K  P+ 
Sbjct: 217 IIFFGTRPCLYLPIAKKLPVHSYWSLITVGIVAGLMAYGYQRSLLNTKWLFNKLKIIPMQ 276

Query: 260 VLGIGGFILGILGVIGGPVSLFKGLDEMQQMVA----------NQAFSTSDYFLLAVIKL 309
              I   +L I   +  P  L      +  +             Q        +  +++L
Sbjct: 277 YHSIVPLLLVIPIGLAFPHVLGGSHYLIDSLFHNPLIIQEEKLGQLSWILIPVVFFLLRL 336

Query: 310 AALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPA------AITVSCAILGIVLVV 363
              +++  S   GG   P + +G  +G +       +           +  ++   +  +
Sbjct: 337 IFSMISYCSSIPGGTFMPILVLGALMGTIFATVFIHLGLISTDNYTNIIIVSMAAYLGAI 396

Query: 364 TRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWL---LLAGKPMMMVNRPKQQ 412
            R  + ++ +   ++     +  + + +  A+L   LL G+P+  V R + +
Sbjct: 397 LRAPFTAIILLTEMIGTVEQVLPMIMSVFIAYLILALLGGEPIYTVLRKQME 448


>UniRef50_C4G1J1 Putative uncharacterized protein n=1 Tax=Abiotrophia defectiva ATCC
           49176 RepID=C4G1J1_ABIDE
          Length = 434

 Score =  187 bits (475), Expect = 9e-46,   Method: Composition-based stats.
 Identities = 59/408 (14%), Positives = 140/408 (34%), Gaps = 28/408 (6%)

Query: 8   TMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTG 67
            +L   + A  +G+    I +    +     NLL             +   I+  L   G
Sbjct: 21  NLLRWCVLATLVGLFVGGISVAFSALDIRANNLL------------KTHPNILFGLPFAG 68

Query: 68  IAVGLVIRFSQGH---AGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIM 124
           + +  + RF+  +                 +P    P +  + ++  A G S+G E   +
Sbjct: 69  LIIVYLYRFAGVYKSKGTNLVISTIQAKTELPVVMAPLIFASTLITHAFGGSVGREGAAL 128

Query: 125 TVNIALAVAIGA---RLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVP 181
            +  A A  +       L    +    +   +    A+FGTP+AA     +    S  + 
Sbjct: 129 QLGSAAAAGLNKIKWLKLSEEEKRMIIMCGMSAAFSAIFGTPIAAVFFPMEV--ASIGII 186

Query: 182 LWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAV 241
            +  +F   +++      + L+      L       +    +   A++A +     ++  
Sbjct: 187 QYSAMFPCFVSSVTARWLSHLYGLEKEHLGRVTDVGLNFDVVWKIALLAIVCGLLSIIFC 246

Query: 242 WCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGP--VSLFKGLDEMQQMVANQAFSTS 299
             L        ++          G  + I+  I       L  G+  +++ V  +     
Sbjct: 247 LLLKGAGTAFSKLHINRYFQIFVGGTIFIVINILLDTKDFLGAGMPVIERAVEGE----- 301

Query: 300 DYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGI 359
             +   ++K+    +   +G++GG I P++F+G   G +       +P ++ V+C + G+
Sbjct: 302 VVWYAFLMKMLLTALCIGAGYKGGEIVPSLFIGATFGNLFAHLF-GLPTSLAVACGMAGL 360

Query: 360 VLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVN 407
            + VT     SL + + +           + +  ++++     +    
Sbjct: 361 FVGVTNCPIASLLIISELFGFREGNIYFLLAITISYIMSGYFGLYSEQ 408


>UniRef50_A6VUX7 Chloride channel core n=2 Tax=Marinomonas RepID=A6VUX7_MARMS
          Length = 579

 Score =  186 bits (474), Expect = 1e-45,   Method: Composition-based stats.
 Identities = 51/380 (13%), Positives = 109/380 (28%), Gaps = 15/380 (3%)

Query: 28  IVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRFSQG-----HAG 82
                +  +                     W +G+     I + L+              
Sbjct: 43  AFFYAVIYLPARYFIG--ADFDSFESLPVEWRVGLSLAACIILALLFTLLPNRLHKVGVP 100

Query: 83  PDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARLLPRV 142
                       +P         +  +GLAGG+S+G E P + +   L   +  +     
Sbjct: 101 YVVERLNYHNGNLPVWNGVVQFFSAAIGLAGGLSIGKEGPAVHLGATLGGYLAEKAKLPQ 160

Query: 143 NR-MEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTG 201
                      AG I A+F TP+A  L   + +           +   L+++    L + 
Sbjct: 161 YGVETLLACGVAGAIAAVFQTPLAGVLFAFEVIFLEYRQRY---VLPVLLSSVIATLVSH 217

Query: 202 LFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVL 261
               P     +     + ++          + I    ++   L     +       V   
Sbjct: 218 YVIGPLDIFSVERVSSVLLST-DLFVACFVLVIFIVFLSALFLHTQKNLWRFSGVSVWWR 276

Query: 262 GIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFR 321
                +   L  +  P +L  G   + ++++         FLL +IK          G  
Sbjct: 277 FFLVAVATSLAAVYLPEALGSGYLSLSRLLSG-DLILYSLFLLILIKTVLTAFTIGLGIP 335

Query: 322 GGRIFPAVFVGVALGLMLHEHVP--AVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVP 379
           GG I P   +G   G+ +           A+     +  ++    +    +L     +  
Sbjct: 336 GGMIGPTFIIGGLAGVQVALVFDNSVADVALFALLGMAAMMAASFQAPLTALVAIIEMTH 395

Query: 380 NTTLLPLLCIVMLPAWLLLA 399
           ++  +     V++ + LL+ 
Sbjct: 396 SSEAIVPALFVIVFSCLLMR 415



 Score = 51.0 bits (121), Expect = 8e-05,   Method: Composition-based stats.
 Identities = 24/191 (12%), Positives = 52/191 (27%), Gaps = 13/191 (6%)

Query: 25  LILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRFSQGHAGPD 84
           +   V++     L  L           +  S  W   ++ +        +   +      
Sbjct: 242 VACFVLVIFIVFLSALFLHTQKNLWRFSGVSVWWRFFLVAVATSLAA--VYLPEALGSGY 299

Query: 85  PACEPLIGAPVPPSAL----PGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARL-L 139
            +   L+   +   +L        V     +  G+  G   P   +     V +      
Sbjct: 300 LSLSRLLSGDLILYSLFLLILIKTVLTAFTIGLGIPGGMIGPTFIIGGLAGVQVALVFDN 359

Query: 140 PRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALT 199
              +   + +L  A  + A F  P+ A +   +  + S      + +   L       L 
Sbjct: 360 SVADVALFALLGMAAMMAASFQAPLTALVAIIEMTHSS------EAIVPALFVIVFSCLL 413

Query: 200 TGLFFHPHFSL 210
             +FFH     
Sbjct: 414 MRVFFHQESVF 424


>UniRef50_C4Z1M2 Chloride channel protein, CIC family n=1 Tax=Eubacterium eligens
           ATCC 27750 RepID=C4Z1M2_EUBE2
          Length = 425

 Score =  186 bits (474), Expect = 1e-45,   Method: Composition-based stats.
 Identities = 66/404 (16%), Positives = 137/404 (33%), Gaps = 13/404 (3%)

Query: 8   TMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTG 67
             L L++  +   +  S +    +     + +L+   +     +  + P  + G+     
Sbjct: 16  QRLKLAVITLFKWLFCSFVCGCFIGSVGAVFHLMLGYV---GSLRVEYPFLLFGLPVAGI 72

Query: 68  IAVGL--VIRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMT 125
           I V +  ++  +                 VP    P +I++ +L    G S G E   + 
Sbjct: 73  IIVFMYNIVHEAGNRGTNLVITAIQSNDEVPGRVAPLIIISTLLTHLCGGSAGREGAALQ 132

Query: 126 VNIALAVAIGARLLPRVNR-MEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWD 184
           V  AL                   +   +    ALFGTP+AAA+   + +  S  V  + 
Sbjct: 133 VGGALGNTFAKLFKFDEKDTRIMIMCGMSACFSALFGTPIAAAVFSMEVI--SVGVMYYA 190

Query: 185 RLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCL 244
            L   ++AA                  +         +     I++ +     ++    L
Sbjct: 191 ALVPCVLAAFVAQGIASALGLESTHFVVDEIASFSFINGSKFIIMSVLFALVSILLCVVL 250

Query: 245 PRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLL 304
                +     N   +  I   +L I        + + G       +  ++F TS  + +
Sbjct: 251 HGTSKLYINYINNPYIRIIIAGVLVISMRYIFGTTDYLG---AGSDIIAKSFVTSCAWYV 307

Query: 305 AVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLVVT 364
            ++K+    V    GF+GG I P +FVG  LG  L      +P  +  +C ++ +   VT
Sbjct: 308 FLLKMLFTAVTLGGGFKGGEIVPTLFVGATLGSFLAPIF-GLPVGLCAACGMVSVFCGVT 366

Query: 365 RDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNR 408
                S  ++  +   +T+     + +  ++LL     +    +
Sbjct: 367 NCPLTSFILSIEMFGASTM-KFTILCIALSYLLSGYYSLYNSQK 409



 Score = 47.5 bits (112), Expect = 9e-04,   Method: Composition-based stats.
 Identities = 21/197 (10%), Positives = 55/197 (27%), Gaps = 2/197 (1%)

Query: 208 FSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFI 267
                    ++ +  +      + +              +   +  ++     L  G  +
Sbjct: 10  TLFEYIQRLKLAVITLFKWLFCSFVCGCFIGSVGAVFHLMLGYVGSLRVEYPFLLFGLPV 69

Query: 268 LGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFP 327
            GI+ V    +    G      ++     +      +A + + + ++    G   GR   
Sbjct: 70  AGIIIVFMYNIVHEAGNRGTNLVITAIQSNDEVPGRVAPLIIISTLLTHLCGGSAGREGA 129

Query: 328 AVFVGVALGLMLHEHVPAV--PAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLP 385
           A+ VG ALG    +          I + C +      +      +   +  V+    +  
Sbjct: 130 ALQVGGALGNTFAKLFKFDEKDTRIMIMCGMSACFSALFGTPIAAAVFSMEVISVGVMYY 189

Query: 386 LLCIVMLPAWLLLAGKP 402
              +  + A  +  G  
Sbjct: 190 AALVPCVLAAFVAQGIA 206


>UniRef50_B2IWH4 Cl-channel, voltage-gated family protein n=2 Tax=Nostocaceae
           RepID=B2IWH4_NOSP7
          Length = 634

 Score =  186 bits (474), Expect = 1e-45,   Method: Composition-based stats.
 Identities = 78/423 (18%), Positives = 149/423 (35%), Gaps = 24/423 (5%)

Query: 11  LLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAV 70
           ++   A+ IG  + + ++    +  ++  L+ + L G +G+       +  V TL G+ V
Sbjct: 39  VVLFLAMLIGGGTGMGVVTFHYLIQLIHQLMLENLMGQIGV--WGAWTLACVPTLGGLIV 96

Query: 71  GLVIRFSQGHAGPDPACEPLIGAPVPPSAL--PGLIVALILGLAGGVSLGPEHPIMTVNI 128
           GL+   +Q       +             L     ++A  + L  G SLGPE P + +  
Sbjct: 97  GLMRWRTQDFGPGLSSLIAASQGTEIKRPLRPVTKMLAASVSLGSGASLGPEGPSVEIGA 156

Query: 129 ALAVAIGARLLPRVNR-MEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLF 187
              +     L     R        +A  + A F  P+A      + + G++         
Sbjct: 157 NFGMLFSVILNVSQERQRLLLGAGAAAGLAAGFNAPIAGVFFALEVVMGATSFATSAVSV 216

Query: 188 APLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLP-- 245
             L A    AL   +      +  +  Y      ++     +   A    +     +   
Sbjct: 217 VLLAA-VVAALIAQIGLGAQPAFDLPAYQVRSPLELPLYLGLGLGASLVSLAYTQLIRLA 275

Query: 246 ------RLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTS 299
                 ++       + P  +  I G ++     +  P  L  G + ++ M+ +  F  S
Sbjct: 276 KACFAGKVRGFAFLGRIPEPIHPIIGGVIIGAVALYFPQILGVGYETVEAMLQDVEFPLS 335

Query: 300 DYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAI--------- 350
              +L V+KL    ++A SGF GG   PA+F+G + G    + +      I         
Sbjct: 336 LLVVLLVVKLLMTAISAGSGFIGGLFAPAMFLGASFGSAYAKLLAVAFPTICDQMAAPPA 395

Query: 351 TVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTL-LPLLCIVMLPAWLLLAGKPMMMVNRP 409
                +  ++    R    ++ M   +  +  + LPL+  V L  WL+   KP    N  
Sbjct: 396 YAMVGMAAVLAASVRAPLTAILMLFELTRDYRIVLPLMAAVGLSVWLVERIKPTFNSNSN 455

Query: 410 KQQ 412
            QQ
Sbjct: 456 LQQ 458


>UniRef50_B9WE28 Voltage-gated chloride channel, putative n=12 Tax=Saccharomycetales
           RepID=B9WE28_CANDC
          Length = 768

 Score =  186 bits (473), Expect = 1e-45,   Method: Composition-based stats.
 Identities = 57/452 (12%), Positives = 119/452 (26%), Gaps = 71/452 (15%)

Query: 13  SLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQD------------------ 54
            +    +G +  LI   +  I S L N+          +++                   
Sbjct: 89  WVVLGIMGCSIGLIAGSLNIITSFLSNIRTGHCKRNFYLSESFCCWGEESDHCDNWVKWT 148

Query: 55  ------SPLWIIGVLTLTGIAVGLVIRFSQGHAGPDPACEP------LIGAPVPPSALPG 102
                    +++  L     A  LV  ++   AG   +         ++   +    L  
Sbjct: 149 SFEFINYIFYVLISLLFAYSAAKLVKFYAPSAAGSGISEIKCIVSGFVMDGFLGWPTLFI 208

Query: 103 LIVALILGLAGGVSLGPEHPIMT----VNIALAVAIGARLLPRVNRMEWTILASAGTIGA 158
             + L L +  G+S+G E P +     V  ++A  I           E+    +A  +  
Sbjct: 209 KSLGLPLAIGSGLSVGKEGPSVHYAVCVGNSIAKLITKYRKSASRAREFLTATAAAGVAV 268

Query: 159 LFGTPVAAALIFSQTLNGSSEV-PLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQ 217
            FG+P+   L   + ++   ++  +W   F  L+A    A              + +   
Sbjct: 269 AFGSPMGGVLFSVEEISTVFQLNTIWKSYFCALIAVTTLAALNPFRTGQMVLFEVTYDTN 328

Query: 218 MEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGP 277
               +I    I+       G++      R+ A   +      V  +    L         
Sbjct: 329 WHYFEIPVYIILGIFGGLYGIIVSKFNIRVVAFRKKHLGNFAVREVLILTLFTASFSYFN 388

Query: 278 VSLFKGLDEMQQMVANQ----------------AFSTSDYFLLAVIKLAALVVAAASGFR 321
             L   + E  Q++ ++                A            ++   +V       
Sbjct: 389 QFLRLDMTETMQILFHECDKNFHHPICDSSNKKAGIIVSLLFATFARMLLTIVTYGCKVP 448

Query: 322 GGRIFPAVFVGVALGLMLHEHVPAVP--------------------AAITVSCAILGIVL 361
            G   P++  G   G  L   V  V                                 + 
Sbjct: 449 AGIFVPSMAAGATFGRALGIIVDLVYANHKDSFVFRNCPKDGKCIIPGTYAFLGAAAGLC 508

Query: 362 VVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLP 393
            +T      + +   +      +    IV+  
Sbjct: 509 GITDLTVTVVIIMFELTGALRYIIPTMIVVAI 540


>UniRef50_B9Z495 Chloride channel core protein n=1 Tax=Lutiella nitroferrum 2002
           RepID=B9Z495_9NEIS
          Length = 554

 Score =  186 bits (473), Expect = 1e-45,   Method: Composition-based stats.
 Identities = 71/406 (17%), Positives = 129/406 (31%), Gaps = 16/406 (3%)

Query: 19  IGIASSLILIVVMKIASVLQNLLWQRLPGTLGIA-QDSPLWIIGVLTLTGIAVGLVIRFS 77
            G   +L       +       L+    G + +A   SP   +    + GIA G +++  
Sbjct: 21  TGCLGALATHGFRLLLDGASRWLFGGDGGPVQVAGALSPGLRVLTPVIGGIAAGWILQQL 80

Query: 78  QG---HAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAI 134
                HA        L    +   A      +  + +  G S+G E  ++ +        
Sbjct: 81  PQIRQHASDYMESIALGDGRLSLRATLLRAASSAMSIVSGSSIGREGSMIQLAALAGSLP 140

Query: 135 GARLLPRVNRMEW-TILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAA 193
            A                +A  + A + TPVA AL   + +  S  +     L       
Sbjct: 141 AALARLGTAHRRLWLACGAAAGVSAAYNTPVAGALFVGEIILRSVTIETLGPLLLAA--- 197

Query: 194 AAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQ 253
           A   LT+   F       +        +  L  A++  +A          L R  A+  Q
Sbjct: 198 AGAQLTSACLFADTAIYQLPPLTTQGDSSGLGFALLGIVAGLLTPGFQLLLHRSKAIFGQ 257

Query: 254 MKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALV 313
           +  P+ +    G        +  P     G   + Q++ + A+       +   KL A  
Sbjct: 258 LPLPLWLKLGLGGAFVGGLSLLTPHVWGNGYRTVGQLL-HTAWPLGLLLGVLTCKLLATA 316

Query: 314 VAAASGFRGGRIFPAVFVGVALGLMLHEHVPAV----PAAITVSCAILGIVLVVTRDGWL 369
            A  SG  GG   P +FVG  LG +    +  +       + V   +   +   T+   +
Sbjct: 317 AATGSGAVGGIFTPTLFVGAVLGAVCGHAITGLTGQPAGPLWVVAGMGAFLAAATQAPLM 376

Query: 370 SLFMAAVVVPNTTLLPLLCIVMLPAWL---LLAGKPMMMVNRPKQQ 412
           ++ M   +         L + +  A L   LL  + +     PK +
Sbjct: 377 AIIMLLEMTRTPGAAVPLMLAVATAHLTVRLLGCRSIYAHALPKSE 422


>UniRef50_A7ZHP7 H(+)/Cl(-) exchange transporter clcA n=152 Tax=Gammaproteobacteria
           RepID=CLCA_ECO24
          Length = 473

 Score =  186 bits (473), Expect = 1e-45,   Method: Composition-based stats.
 Identities = 76/428 (17%), Positives = 140/428 (32%), Gaps = 24/428 (5%)

Query: 4   PRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTL-GIAQDSPLWIIGV 62
            R +T L +   A  +G    L  +   K  + LQN     L  T         +  +  
Sbjct: 27  ERDKTPLAILFMAAVVGTLVGLAAVAFDKGVAWLQNQRMGALVHTADNYPLLLTVAFLCS 86

Query: 63  LTLTGIAVGLVIRFSQGHAGP-DPACEPLIGAPVP---PSALPGLIVALILGLAGGVSLG 118
             L      LV +++    G   P  E  +    P      LP      +  L GG+ LG
Sbjct: 87  AVLAMFGYFLVRKYAPEAGGSGIPEIEGALEDQRPVRWWRVLPVKFFGGLGTLGGGMVLG 146

Query: 119 PEHPIMTVNIALAVAIGA--RLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNG 176
            E P + +   +   +    RL     R       +A  + A F  P+A  L   + +  
Sbjct: 147 REGPTVQIGGNIGRMVLDIFRLKGDEARHTLLATGAAAGLAAAFNAPLAGILFIIEEMRP 206

Query: 177 SSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAA 236
                L   + A  +      +   +F H    + +       +  +    I+  I    
Sbjct: 207 QFRYTL-ISIKAVFIGVIMSTIMYRIFNHEVALIDVGKLSDAPLNTLWLYLILGIIFGIF 265

Query: 237 GMVAVWCLPRLHAMMHQ-----MKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMV 291
           G +    +  +  ++H+     +   VL+ G  G + G+LG    P +   G + +  + 
Sbjct: 266 GPIFNKWVLGMQDLLHRVHGGNITKWVLMGGAIGGLCGLLG-FVAPATSGGGFNLIP-IA 323

Query: 292 ANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPA--- 348
               FS      + V ++   ++  +SG  GG   P + +G  LG         +     
Sbjct: 324 TAGNFSMGMLVFIFVARVITTLLCFSSGAPGGIFAPMLALGTVLGTAFGMVAVELFPQYH 383

Query: 349 ---AITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLL---LAGKP 402
                     +  ++    R     + +   +  N  L+  + I  L A LL     GKP
Sbjct: 384 LEAGTFAIAGMGALLAASIRAPLTGIILVLEMTDNYQLILPMIITGLGATLLAQFTGGKP 443

Query: 403 MMMVNRPK 410
           +      +
Sbjct: 444 LYSAILAR 451


>UniRef50_B2VDE2 Cl-channel, voltage gated n=4 Tax=Enterobacteriaceae
           RepID=B2VDE2_ERWT9
          Length = 563

 Score =  186 bits (473), Expect = 1e-45,   Method: Composition-based stats.
 Identities = 67/417 (16%), Positives = 162/417 (38%), Gaps = 22/417 (5%)

Query: 2   LHPRARTMLLL--SLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWI 59
           ++ R+R  L     L A+ +G+ +SL+ +   +    +  LL+          +  P + 
Sbjct: 1   MNSRSRHALNWTRILVAIPVGLVASLVTLAFREAIVWIDGLLFNGQTDITQAMRIYPWYC 60

Query: 60  IGVLTL-TGIAVGLVIRFS------QGHAGPDPACEPLIGAPVPPSALPGLIVALILGLA 112
             ++    G+  G  +R++      Q                VP        ++ +  ++
Sbjct: 61  WPLIVGCGGLIAGYFLRYATAIEQKQASRSDYLEVINARLDAVPTRTSLFRGLSSLASIS 120

Query: 113 GGVSLGPEHPIMTVNIALAVAIGARLLPRVNRM--EWTILASAGTIGALFGTPVAAALIF 170
            G S+G E P++ ++      +G  L   +     +   +A+A  + +++  P+A+A+  
Sbjct: 121 SGASIGREGPMVQLSALSGSLMGRWLFKNLALKNSDVVAMAAAAGLSSVYHAPLASAIFV 180

Query: 171 SQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYG-QMEMTDILSGAIV 229
           ++    +  +    RL   ++++    LT     +     P +H   ++    I     +
Sbjct: 181 AEI---AFGISAMQRLIPLIISSGTAVLTMWSLGYHSAIYPFSHGQFELAPESITLTIAI 237

Query: 230 AAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQ 289
             +A   G V +  +     +   +++ + +    G +L     IG    L  G + + +
Sbjct: 238 GLLAGLLGWVMIAMINHSKRLFAPLRS-LPLRLGLGGLLVGGLAIGSSQILGNGYEVIVR 296

Query: 290 MVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEH-----VP 344
           ++A   F       L ++K+ A  ++  S   GG   PA+ +G  +G M+         P
Sbjct: 297 IMAG-DFLLPMLLALLLLKMLATAISVGSSAVGGLFTPALLIGALMGSMMALLAVKAGFP 355

Query: 345 AVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGK 401
               A+  +  +  ++  V++   +++ M   +  N++LL    I  + A ++    
Sbjct: 356 PGNVAVFAAIGMGALLASVSQAPLMAMLMVLEMTLNSSLLFPAMIASVLASMVAYRL 412


>UniRef50_Q1LQV6 Cl-channel, voltage gated n=66 Tax=Proteobacteria
           RepID=Q1LQV6_RALME
          Length = 637

 Score =  185 bits (471), Expect = 2e-45,   Method: Composition-based stats.
 Identities = 76/412 (18%), Positives = 148/412 (35%), Gaps = 17/412 (4%)

Query: 12  LSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPL---WIIGVLTLTGI 68
           L+  A+ IG  S+    V++ +     NL + +       +        W+I V  + G+
Sbjct: 62  LAAIALGIGAISTGAAYVLVNLIHFFTNLFFFQTLSFADRSPAGHTLGPWVIVVPAIGGL 121

Query: 69  AVGLVIRFS-----QGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPI 123
            VGL+ R+                     + + P       ++  + +  G   G E PI
Sbjct: 122 IVGLMARYGSDKIRGHGIPEAIEAVLFGKSKMSPKVAVLKPLSSGIVIGSGGPFGAEGPI 181

Query: 124 MTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPL 182
           +    ++A  +   L L    R    +  +   + A+FGTPVAA L+  + L        
Sbjct: 182 IMTGGSIASLLAQYLHLTAAERKTLLVSGACAGMTAIFGTPVAAVLLAIELLLFELRP-- 239

Query: 183 WDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVW 242
              L    +A A         F      P+       +  + S  +   +  A G     
Sbjct: 240 -RSLLPVALACAVAGFLRPFVFEAGPLFPLQTAPASTLA-LGSCVLAGLLCGALGAGLTL 297

Query: 243 CLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYF 302
            L R       ++   +     G ++  +G    P +L  G D +  ++ N+    +   
Sbjct: 298 ALYRTEDAFDHLRLHWMWWPAIGGLVVGIGGYFEPRALGVGYDVIGDLLNNRLLVEAAVA 357

Query: 303 LLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLV 362
           LLAV  +   + A  SG  GG + P + +G  LG++L   +P     +     + G++  
Sbjct: 358 LLAVKAVI-WIAALGSGTSGGVLAPLLMLGAGLGVVLAPMLPGGSPGLWALVCMAGVLGS 416

Query: 363 VTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAW---LLLAGKPMMMVNRPKQ 411
           V      ++  A  +  ++  L  L +    A+   +L   + +M     ++
Sbjct: 417 VLGAPLTAIVFAFGLTHDSEALLPLLLTTAVAYGFSVLTMKRSIMTEKIARR 468


>UniRef50_B5EQW9 Chloride channel core n=2 Tax=Acidithiobacillus ferrooxidans
           RepID=B5EQW9_ACIF5
          Length = 474

 Score =  185 bits (471), Expect = 2e-45,   Method: Composition-based stats.
 Identities = 69/435 (15%), Positives = 139/435 (31%), Gaps = 28/435 (6%)

Query: 5   RARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNL---------------LWQRLPGTL 49
           + +      +  V IGI   ++ +V + I      L                   +    
Sbjct: 32  KGKNKARYFITPVIIGIIVGVLSLVFIDIMDFFTRLSLGVVAHFTPPRSSGFGGGVESRY 91

Query: 50  GIAQDSPLWIIGVLTLTGIAVGLVIRFSQGHAGPDPACEP-----LIGAPVPPSALPGLI 104
             A   P  I  V  +     G++  F   + G   A +           +        +
Sbjct: 92  TSAPGYPFMIPLVEGMAAFISGVLSYFMIKNPGSLGANKAIRAYHENPESLTLKEAFTTL 151

Query: 105 VALILGLAGGVSLGPEHPIMTVNIALAVAIGARLLPR-VNRMEWTILASAGTIGALFGTP 163
               + L  G   G E  +  V  ++ V I   L  +     E   +     +GA+F  P
Sbjct: 152 FTSAMVLGSGGPSGREGAVSMVGGSVGVFIAKLLRQKPHEVREALAIGVGAGLGAMFKAP 211

Query: 164 VAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDI 223
           +A A+  S+                   AAA   + T + F P F + +      E+  I
Sbjct: 212 LAGAIASSEIFFKHDFDIETIIPAFAASAAAYLVVATKVGFSPLFRIGVLPVHNFELRYI 271

Query: 224 LSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKG 283
           L  +I    +       +W    +  +  ++K P+ V  + G +L     +    ++  G
Sbjct: 272 LWFSIFGIFSGLIARFLLWVFYYISDLFKKLKQPIYVTALIGGVLAGCIGLLSSYAIGNG 331

Query: 284 LDEMQQMVANQAFSTSDYFLLAVIK-LAALVVAAASGFRGGRIFPAVFVGVALGLMLHEH 342
              +Q ++ ++         L +I  + A+ + A SG  GG   P V +G   G +    
Sbjct: 332 YGWLQLIMDHKISPGVSELTLGIICVILAMSLIAGSGASGGAFSPTVVIGGLSGALFWHF 391

Query: 343 VPA------VPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWL 396
                    +P A+ V   ++ +  V       ++ M   +  +  +L    + +  A +
Sbjct: 392 AKVVSPNLNIPIAMFVVVGMMAVFSVAANAPLSTIVMITEMTGSYGVLLPAMLTVGIAMM 451

Query: 397 LLAGKPMMMVNRPKQ 411
                 +       +
Sbjct: 452 FGGEHSLFNAQHDHR 466


>UniRef50_C0QQU7 Chloride channel protein n=1 Tax=Persephonella marina EX-H1
           RepID=C0QQU7_PERMH
          Length = 586

 Score =  185 bits (470), Expect = 3e-45,   Method: Composition-based stats.
 Identities = 58/425 (13%), Positives = 131/425 (30%), Gaps = 32/425 (7%)

Query: 13  SLPAVAIGIASSLILIVVMKIASVLQNLLWQRL-------------PGTLGIAQDSPLWI 59
            L  V IG+ + L  I+ +K   +  +     +                     +    +
Sbjct: 15  FLLPVLIGLFAGLFAIIFLKAIKISSDFFLGGIVSYQPPSPFGEGGSHFFSFEMERAYLL 74

Query: 60  IGVLTLTGIAVGLVIRFSQ---GHAGPDPACEPLIGAP-VPPSALPGLIVALILGLAGGV 115
                L G+ VG+++          G D A         +        ++   + +  G 
Sbjct: 75  PISTALGGLIVGILVYLFSPESAGVGTDAAIRAFHHRKYLGLKTSIMKLITAAVTIGSGG 134

Query: 116 SLGPEHPIMTVNIALAVAIGARLLPRVNRMEW-TILASAGTIGALFGTPVAAALIFSQTL 174
             G E PI  +   +   +G          +    +     I  +F  P A A+I S+  
Sbjct: 135 VSGKEGPIALIGAGIGSFLGRIFKLSDREKDIALAVGMGAGIAGVFKAPFAGAIISSEVF 194

Query: 175 NGSSEVPLWDRLFAPLMAAAAGALT--TGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAI 232
                    + L    +A+    +   + L F P F + +  +  + + D  +   +   
Sbjct: 195 YKKDFET--ETLIPSFIASFIAFIVVGSFLGFSPLFHIELPQFNGLSVNDAAAYIFLGIS 252

Query: 233 AIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVA 292
                 + ++ L +   + + +    +     G     L  +  PV++  G   +Q +++
Sbjct: 253 TAMIARLMIFSLDKSREIFNSLGIHPVFKPAVGGFFVGLMGMFTPVAIGTGYGWLQMIMS 312

Query: 293 NQAFSTSDYFLL--AVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAV---- 346
                 S   ++    + + A      SG  GG   P++ +G   G  ++  + A+    
Sbjct: 313 GNLVYLSPLLIVVSIFVVILAFSFTLGSGGSGGVFGPSLVIGGLTGASVYYLLSAIGFQE 372

Query: 347 ----PAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKP 402
                        ++       +    +L + A +     LL    I +  +  L   K 
Sbjct: 373 SSSFNITALTVVGMVSTFAAAAKAPLSTLILVAEITGGYQLLVPAIIAVAISHFLSGEKS 432

Query: 403 MMMVN 407
           +    
Sbjct: 433 IFKSQ 437


>UniRef50_Q9VGH7 Chloride channel protein 2 n=19 Tax=Eumetazoa RepID=CLCN2_DROME
          Length = 1193

 Score =  185 bits (469), Expect = 3e-45,   Method: Composition-based stats.
 Identities = 61/449 (13%), Positives = 121/449 (26%), Gaps = 77/449 (17%)

Query: 13  SLPAVAIGIASSLILIVVMKIASVLQNL-LWQRLPGTLGIAQDSPLWIIGVLTLTGIAVG 71
            +    +GI  +L+  ++ K  S+  N  +W     T         W+   + L   + G
Sbjct: 172 WVFLALLGIIMALLSFIMDKGISICTNARIWLYRDLTSQPFVQYIAWVSLPVCLILFSAG 231

Query: 72  LVIRFSQGHAGP-DPACEPLIGA-----PVPPSALPGLIVALILGLAGGVSLGPEHPIMT 125
            V   +    G   P  + ++        +    L   ++ L   L  G+ LG E P + 
Sbjct: 232 FVHLIAPQSIGSGIPEMKTILRGVQLKEYLTFKTLVAKVIGLTATLGSGMPLGKEGPFVH 291

Query: 126 VNIALAVAIGARLLP-------RVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSS 178
           +   +A  +   +              E    A A  +GA F  PV   L   +      
Sbjct: 292 IASIVAQLLSKLVTSFQGIYENESRNSEMLAAACAVGVGACFAAPVGGVLFSIEVTTTYF 351

Query: 179 EV-PLWDRLFAPLMAAAAGALTTGLF-----FHPHFSLPIAHYGQMEMTDILSGAIVAAI 232
            V   W   FA +  A    L    F         F          +  ++   A++  +
Sbjct: 352 AVRNYWRGFFAAVCGATVFRLLAVWFQNADTVRALFLTNFTTEFPFDPQELFVFALIGLV 411

Query: 233 AIAAGMVAVW-------CLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLD 285
               G   VW        +     M   ++    +    GF+  ++  I  P  L  G  
Sbjct: 412 CGLGGASYVWVHRRYVLFMRSNKRMNKFLQKNRFLYP--GFLALLVSSISFP--LGTGQF 467

Query: 286 EMQQMVANQAFSTSD-------------------------------YFLLAVIKLAALVV 314
              ++  ++  +                                    +  +      ++
Sbjct: 468 LAGELSTHEQVTQLFSNFTWSRDDLTVEQAAVVTHWMTSYTSVFGNLVIYTLFTFVVSII 527

Query: 315 AAASGFRGGRIFPAVFVGVALGLMLHEHVPAVP--------------AAITVSCAILGIV 360
           A+      G   P   +G   G ++ E +                               
Sbjct: 528 ASTIPVPSGMFIPVFKIGAGFGRLVGEFMAVTFPHGVRYGGRLSPIMPGGYAVVGAAAFS 587

Query: 361 LVVTRDGWLSLFMAAVVVPNTTLLPLLCI 389
             VT    ++  +   +    T +  + I
Sbjct: 588 GSVTHTVSVA-VIIFEMTGQITHVVPVMI 615


>UniRef50_C8X5N8 Cl-channel voltage-gated family protein n=1 Tax=Desulfohalobium
           retbaense DSM 5692 RepID=C8X5N8_DESRD
          Length = 605

 Score =  185 bits (469), Expect = 3e-45,   Method: Composition-based stats.
 Identities = 67/452 (14%), Positives = 133/452 (29%), Gaps = 71/452 (15%)

Query: 11  LLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQD-------------SPL 57
              L  + IG+ + L  I+   +  +  +     L G                    S  
Sbjct: 25  KWLLVYILIGVIAGLGSILFHTLCELGMHFFLDGLAGYRPPVPAGEHALLPPTDTPFSRW 84

Query: 58  WIIGVLTLTGIAVGLVIR-FSQGHAGPD----PACEPLIGAPVPPSALPGLIVALILGLA 112
            ++ +  L G+  G ++  ++    G             G  +         VA  + L 
Sbjct: 85  ILLFLPALGGLVSGWLVYTYAPEAEGHGTDSAIDAYHNKGGQIRGRVPIIKTVASAITLT 144

Query: 113 GGVSLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFS 171
            G S G E PI  +       +G +L L    R        A  +G++F  P+A AL  +
Sbjct: 145 TGGSGGREGPIAQIGAGFGSFLGNQLGLSERERRIMLAAGVAAGVGSIFRAPMAGALFAA 204

Query: 172 QTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAA 231
           + L    E    + +    +A+A       L +         ++      ++   A++A 
Sbjct: 205 EVLYREPEFE-SEVIIPAGIASAVAYCIFCLVYGWGSLFHAPNFTFTNPLELGPYALLAL 263

Query: 232 IAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMV 291
           +  A G V V C   +HA+  ++          G +L        P +L  G   +QQ +
Sbjct: 264 VLTAGGFVYVKCFHGVHALFAKIPIKNHFKPAIGGLLTGGIGFFLPQTLAFGYGVVQQAI 323

Query: 292 ANQAFSTSDYFLLAVIKLAALVV---------------------------AAASGFRGGR 324
             +    +    +A+ K+                                   +    G 
Sbjct: 324 NGE-LGIALLLGVALGKILTTSFTISSGGSGGVFGPSVVIGGALGGGVGQTVDALLP-GL 381

Query: 325 IFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLL 384
           I P    G  + + +                       V+     ++   + +  +  LL
Sbjct: 382 IDP----GAFIIVGMAGFF-----------------TAVSNTPVSTIIFVSEMTGSYHLL 420

Query: 385 PLLCIVMLPAWLLLAGKPMMMVNRPKQ-QPPH 415
               +V     +L     + +     + Q P 
Sbjct: 421 LPSLLVCFLCQILAQKVTIYVEQYANKLQSPA 452


>UniRef50_A3NY48 Chloride transporter, chloride channel (ClC) family n=71
           Tax=Burkholderiales RepID=A3NY48_BURP0
          Length = 578

 Score =  184 bits (468), Expect = 6e-45,   Method: Composition-based stats.
 Identities = 68/436 (15%), Positives = 143/436 (32%), Gaps = 32/436 (7%)

Query: 2   LHPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIG 61
           L  R + +           +   L  ++  ++        W              L  + 
Sbjct: 35  LTRRTQRIWRQYGVFWLGAVVVGLTAVMYARLID------WGYEAFRSLGQGRPWLPFLL 88

Query: 62  VLTLTGIAVGLVIRFSQGHAGP-DPACEPLIGAP--------VPPSALPGLIVALILGLA 112
              +  ++V L  RF +G  G   P     + A         +    L G ++  +LG+A
Sbjct: 89  TPAIAALSVWLTRRFFRGAEGSGIPQVIATLHAQPSAFGSRLLTLRILFGKVLISLLGIA 148

Query: 113 GGVSLGPEHPIMTVNIALAVAIGARLLPRVN--RMEWTILASAGTIGALFGTPVAAALIF 170
           GG ++G E P + +  +L   +             +  +  +A  + A F TP+A  +  
Sbjct: 149 GGFTIGREGPTVQIGASLMFNLRRFYPRSNALIERQLVLAGAAAGLSAAFNTPLAGVVFA 208

Query: 171 SQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEM-----TDILS 225
            + L+ S        L   ++ A             +        GQ          +L+
Sbjct: 209 IEELSRSFSARASGVLITAIIIAGV---IALGLNGNYTYFGTIEIGQHFPKMLAAAVLLT 265

Query: 226 GAIVAAIAIAAGMVAVWCLPRL--HAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKG 283
             +        G + +     L    +    + P++     G  +  +GV  G  +   G
Sbjct: 266 ALVTGVAGGLFGWLLLNTGRWLPARLLALYRERPIVFAAACGLAIAAVGVASGGTTFGSG 325

Query: 284 LDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHV 343
             E + ++  +        L   +K+ ++V +   G  GG   P++ +G   G +LH   
Sbjct: 326 YAEARGLLDGRE---QLSVLYPFLKMISMVASYLPGIPGGIFAPSLSIGAGFGNLLHFVF 382

Query: 344 PAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGK-- 401
             +   + ++ A++G +  VT+    S  +   ++    L+  L    L A  +      
Sbjct: 383 SGMHLPMLIALAMVGYLAAVTQSPITSFVIVMEMINGHALVISLMATALIASRVSRLFVP 442

Query: 402 PMMMVNRPKQQPPHDN 417
           P+      +   P   
Sbjct: 443 PLYETLAERYLKPPQP 458


>UniRef50_Q3JE62 Cl-channel, voltage gated n=2 Tax=Nitrosococcus oceani
           RepID=Q3JE62_NITOC
          Length = 575

 Score =  184 bits (467), Expect = 6e-45,   Method: Composition-based stats.
 Identities = 64/384 (16%), Positives = 122/384 (31%), Gaps = 18/384 (4%)

Query: 27  LIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLV----IRFSQGHAG 82
            +        +  +                L  +    + G+++GL+      +      
Sbjct: 42  TVAFRLAVD-VDQIALLPSHQVDDFESLDWLERLLFPIVGGLSIGLLQELAHTYRAVGVV 100

Query: 83  PDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARL-LPR 141
                       +P        V   L +  G S+G E P + +  A    +G  L LP 
Sbjct: 101 HVLERIAYYQGRLPWRNALQQFVTGALSIICGHSVGREGPSVHLGAAGGSLLGQWLELPN 160

Query: 142 VNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTG 201
                      A  I A F TP+A  L   + +    ++     +   ++AA  GA  + 
Sbjct: 161 NALRTLVACGIAAAIAASFNTPLAGVLFSMEVIMMQYQLA---GVAPIILAAVVGAAISW 217

Query: 202 LFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVL 261
             F P  +  +       + D     ++  +      V    +     +    + PV   
Sbjct: 218 AVFGPSPAFFVPPTEMHSLLDFPYLVLIGFVVGILAAVYNRLMRFFSGLEK--QRPVWQR 275

Query: 262 GIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFR 321
                +L  L  I  P  +  G D +  ++  Q F  S   ++ ++KL A       G  
Sbjct: 276 CTAAGLLVGLCSIAVPEIMGLGYDTVNAILMGQ-FGLSALVVITIVKLFATTACVGLGIP 334

Query: 322 GGRIFPAVFVGVALGLMLHEHVPAV------PAAITVSCAILGIVLVVTRDGWLSLFMAA 375
           GG I P + +G A G  L     A+      P A+     +  ++    +    +L    
Sbjct: 335 GGLIGPTLVIGTAAGGALGIIGTALLPQEASPIALYAMVGMAAMMSATLQAPLAALMALV 394

Query: 376 VVVPNTTLLPLLCIVMLPAWLLLA 399
            +   T +L    + ++ A L+  
Sbjct: 395 ELTAGTYILFPGMLAVVVANLVAR 418


>UniRef50_C1F1A6 Chloride transporter, ClC family n=1 Tax=Acidobacterium capsulatum
           ATCC 51196 RepID=C1F1A6_ACIC5
          Length = 472

 Score =  183 bits (466), Expect = 8e-45,   Method: Composition-based stats.
 Identities = 62/423 (14%), Positives = 130/423 (30%), Gaps = 27/423 (6%)

Query: 6   ARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTL 65
           +R ++   + A  +G+ + L++ ++  +            P  LG+    P  I+  L L
Sbjct: 46  SRDLIKWLIAAPLVGVITGLLITLIAVVILKGIW------PPVLGLYLHHPWTILPGLLL 99

Query: 66  TGIAVGLVIRFSQGHAGP-----DPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPE 120
            G+  GL++++   +                   +   +    ++A I  +  G S   E
Sbjct: 100 CGLLTGLIMQWFTPNPDEHSTEEVIRSYHEHSGRMNLRSFVPKLIAAITTVGLGGSAALE 159

Query: 121 HPIMTVNIALAVAIGARL-----LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLN 175
            P +    A+   +  RL     L   +R    I  +A  + A+F  P+   +   +   
Sbjct: 160 GPSIYGGGAVGSLLWTRLQKRLRLTGTDRRILLICGAAAGMSAVFRAPLTGIVFALEMPY 219

Query: 176 GSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIA 235
                   + L   L+A+     T                      D+   A++  +   
Sbjct: 220 KDDLAH--EALVPSLIASVVSYATLASILGSQPLFGFHSAVTWRDADLAWCALLGLLVGL 277

Query: 236 AGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVS-------LFKGLDEMQ 288
                V    R      Q + P  +    G     L               L    + + 
Sbjct: 278 VATAFVTTFRRARRWFVQWRRPHWIKLTLGSFATGLCGFAFLALYRGPLVPLGANYEAV- 336

Query: 289 QMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHE-HVPAVP 347
            ++ +Q  S+ +  + +V+KLAA +   A+G       P    G ALG    +    +  
Sbjct: 337 GILLHQHHSSLELLVFSVLKLAATLFTLAAGGVSAMFVPLFLTGGALGTAFAQSVAHSSA 396

Query: 348 AAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVN 407
             +  +  +   +    +    ++   A        L    I    A+++          
Sbjct: 397 PELYAAVGMASFIAAGYKTPLAAVVFVAEATGAHAFLIPALIGAAVAYVVSGDASASGDQ 456

Query: 408 RPK 410
           R  
Sbjct: 457 RLH 459


>UniRef50_A5DHQ2 Putative uncharacterized protein n=2 Tax=Pichia guilliermondii
           RepID=A5DHQ2_PICGU
          Length = 1002

 Score =  183 bits (466), Expect = 8e-45,   Method: Composition-based stats.
 Identities = 47/401 (11%), Positives = 111/401 (27%), Gaps = 68/401 (16%)

Query: 81  AGPDPACEPLIGAPVPPS-----ALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIG 135
               P  + ++   V         L    +ALI  +A G++LG E P + +   +   + 
Sbjct: 334 GSGVPEVKTILSGFVIRRFLGTYTLVAKTIALIFAIASGMALGKEGPYVHLATCVGNIMT 393

Query: 136 ARLLPRVN----RMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEV-PLWDRLFAPL 190
             +    N    + +    +++  +   FG+P+   L   + +N       L+   F  +
Sbjct: 394 RFVPYVKNNDFMKKQILSASASSGVALAFGSPLGGVLFILEEINHYLPSHQLFQVFFCAI 453

Query: 191 MAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAM 250
            +                   + +    E  ++L    + A   A G   V         
Sbjct: 454 TSTLFLKFLNPYGTGKTVLFELKYTSDWETVELLFFIFLGAAGGAFGACFVKFTGWWGKT 513

Query: 251 MHQMK----NPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFS--------- 297
             ++K    +P+  + +   I G +     P ++    + +  +    +           
Sbjct: 514 FRKLKPINGHPIFEVFLVSLITG-IVSFWNPYTIQASSELVLDLATPCSTELDSSLCPTI 572

Query: 298 -------TSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPA----- 345
                          ++KL    +        G   P++ VG   G ++   +       
Sbjct: 573 HGEFVREIKSLIFAFIVKLVLTFITFGLKVPCGIYVPSMVVGALFGRIVGMFIQWCNYSF 632

Query: 346 -----------------------------VPAAITVSCAILGIVLVVTRDGWLSLFMAAV 376
                                        V   I    +    +  VTR     + +   
Sbjct: 633 NLAVPADGLATSTSIMRYICSPDSSNNDCVDLGIYSMISAGAFMAGVTRMNIALVTILFE 692

Query: 377 VVPNTTLLPLLCIVMLPAWLLLA---GKPMMMVNRPKQQPP 414
           +  + T +  + I +  A  + +      +      +   P
Sbjct: 693 LTSSYTYVLPISIAIAVANWVGSVLEKNSLYESLLIQNDYP 733


>UniRef50_Q5KGF6 Putative uncharacterized protein n=1 Tax=Filobasidiella neoformans
           RepID=Q5KGF6_CRYNE
          Length = 897

 Score =  183 bits (466), Expect = 8e-45,   Method: Composition-based stats.
 Identities = 43/364 (11%), Positives = 98/364 (26%), Gaps = 48/364 (13%)

Query: 79  GHAGPDPACEPL-----IGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVA 133
                 P  + +     I   +    L      L L +  G+SLG E P++ ++  +   
Sbjct: 298 AAGSGIPEIKTILSGFVIHGYLGGWTLLTKSAGLALSVGSGLSLGKEGPLVHMSSCVGNI 357

Query: 134 IGARLL----PRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSE-VPLWDRLFA 188
           +    L        R E    A A  +   FG PV   L   + ++       +W   + 
Sbjct: 358 VSRMFLKFECNEAKRREVLSAACAAGVAVAFGAPVGGVLFSLEEVSYYFPPKVMWRSFWC 417

Query: 189 PLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLH 248
             +AA                  + +  +    + +   ++       G V         
Sbjct: 418 AAIAAITLKALNPFGNGSLVLFAVTYTKEYHYWEYIIFVVLGVFGGLYGAVFARLNIIWS 477

Query: 249 AMMH---QMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQ----------- 294
             +     ++   +   +   +L  +     P +   G + +  +               
Sbjct: 478 RHVRNGTWLRRHPIFEVVLVVLLTTIVSFSNPYTRMGGTEFVASLFEECNSSSSSSLCVN 537

Query: 295 -----AFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVP-- 347
                A    + F+  +IK    ++        G   P++ VG   G ++   +  +   
Sbjct: 538 HPHELATVIWEVFMALIIKGCLTIITFGIKVPAGIFIPSLAVGACFGRIVGHMMEYIEFT 597

Query: 348 -----------------AAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIV 390
                              +         +  VTR       +   +      +  + + 
Sbjct: 598 YPELSIFNVCKDTDCIVPGVYAMVGAAATLAGVTRTTVSLAVIMFELTSTLNYVVPVMLS 657

Query: 391 MLPA 394
           +L A
Sbjct: 658 ILIA 661


>UniRef50_Q8KPV0 EriC n=4 Tax=Chroococcales RepID=Q8KPV0_SYNE7
          Length = 463

 Score =  183 bits (466), Expect = 9e-45,   Method: Composition-based stats.
 Identities = 59/407 (14%), Positives = 127/407 (31%), Gaps = 15/407 (3%)

Query: 11  LLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAV 70
           L+ L A   G+   L+      + S   N   + L       +     ++    +  +  
Sbjct: 31  LVLLWAAIAGLMVGLVGGAFRWLTSATLNGRVRWLASLPQGPELVAS-VLLSSGMVALGF 89

Query: 71  GLVIRFSQGHAGP-DPACEPLIGAPVP---PSALPGLIVALILGLAGGVSLGPEHPIMTV 126
            L+ RF+   +G   P  E  +           LP   +A IL L  G+ +G E P + +
Sbjct: 90  YLMRRFAPDTSGSGIPQIEGWLAGFFSLFWWRVLPVKFLAGILTLGSGMVMGREGPTIQM 149

Query: 127 NIALAVAIGARLLPRVNR-MEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDR 185
             A+   +         +       ++   +   F  P+A  +   + +  +        
Sbjct: 150 GGAIGQMVSDWFRASTEQARVLVAASAGAGLATAFNAPLAGIVFVFEEMRPTF-QNRLRA 208

Query: 186 LFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLP 245
             A  +A     +   L      ++ +A +G   ++ +    ++     A G      L 
Sbjct: 209 YQAVTIACITATIGLQLLLGKGPTIELAQFGAPPLSSLWVFVLLGLACGAIGYSFNRLLV 268

Query: 246 RLHAMMHQMK-NPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLL 304
                   +   P+ + G+G      L     P +   G + +     +         LL
Sbjct: 269 WSLNCFATLHGLPLRLTGLGVGGFIGLVSWLYPPATNSGENLV-LWAFDTVEPIHTLLLL 327

Query: 305 AVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVP------AVPAAITVSCAILG 358
             ++ A  ++   SG  GG   P + +     L L +          +P  +     +  
Sbjct: 328 CSLRFALTLLCYGSGAPGGIFAPLLSIATLFSLGLGQLTIDWLPGLLLPPEVLAIAGMGA 387

Query: 359 IVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMM 405
            V    +    ++ +   +  N  L+  + +    A L+  G     
Sbjct: 388 FVAATIQSPLTAILLTTEITSNYQLILPIMVSCSAATLIAHGLGSRP 434


>UniRef50_B8HL24 Chloride channel core n=1 Tax=Cyanothece sp. PCC 7425
           RepID=B8HL24_CYAP4
          Length = 897

 Score =  183 bits (466), Expect = 9e-45,   Method: Composition-based stats.
 Identities = 69/418 (16%), Positives = 138/418 (33%), Gaps = 21/418 (5%)

Query: 2   LHPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIG 61
           L    R   +  L A  IG+ S+L  +++ +  + +++           +     + ++G
Sbjct: 14  LQRLLRPKSVAILEACLIGLVSALAAVLLKQAIAAMESWTAAIGADLPPLLILPVIGLLG 73

Query: 62  VLTLTGIAVGLVIRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEH 121
            L    +        +        A        +        +V+  L L  G++LG + 
Sbjct: 74  GLLSGWLIEWAAPEATGSGIPQVKAALGYASIALDLRVAVVKLVSTTLALGAGLALGRQG 133

Query: 122 PIMTVNIALAVAIGARLL-PRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEV 180
           P + +  ALA      L      + +     +A  + A F  P+A  L   + L      
Sbjct: 134 PTVQIGAALAGQFSRWLATSPAYQRQLIAAGAAAGLAAGFNAPIAGVLFVIEELLQDLSE 193

Query: 181 PLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYG-QMEMTDILSGAIVAAIAIAAGMV 239
                L   ++AA  G + + L         ++       + DI    ++ AIA   G  
Sbjct: 194 ---LTLGTAILAAFVGGVVSRLLGGRGLIPDLSGIDLSFTLMDIPVLMLLGAIAGVLGAS 250

Query: 240 AVWCLPRLHAMMHQM---KNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAF 296
               +        Q      P   +G+ G I G++     P+         Q ++     
Sbjct: 251 FNRGILTSLRFYRQYLPGWRPSWQMGLAGAISGMILAFLPPILRSS--SGTQDLLVLGEI 308

Query: 297 STSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVP--------- 347
                 +  V K   +++A  SG  GG   P++ +G ALG ++ +    V          
Sbjct: 309 GWQITAIAFVGKFLLVLLAYGSGVPGGLFAPSLILGSALGGLIGQMAQGVQLELNGTVLS 368

Query: 348 --AAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPM 403
               I     +      VTR    ++ +   +  +  ++  L I  + A+L+      
Sbjct: 369 QAPVIYTLTGMGAFFSAVTRGPITAIVIVFELTMDFDVVLPLMIGSVVAYLVAEKVSK 426


>UniRef50_Q17804 Protein C07H4.2, confirmed by transcript evidence n=4
           Tax=Caenorhabditis RepID=Q17804_CAEEL
          Length = 797

 Score =  183 bits (466), Expect = 9e-45,   Method: Composition-based stats.
 Identities = 57/486 (11%), Positives = 131/486 (26%), Gaps = 95/486 (19%)

Query: 13  SLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLW-------------- 58
            +  + +G+A+     ++   A  + +L          +  +   W              
Sbjct: 115 WICVLFVGLAAGATAGIIDIGARWMSDLKTGVCADRFWLDHEHCCWSSNDTFYKDDDCKA 174

Query: 59  --------------------------IIGVLTLTGIAVGLVIRFSQGHAGP-DPACE--- 88
                                     I   + ++ +AV  V  F+    G   P  +   
Sbjct: 175 WTKWPWMLNYYNSSSFLFLFLEWIFYIGWAVAMSTLAVLFVKIFAPYACGSGIPEIKCIL 234

Query: 89  --PLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARL----LPRV 142
              +I   +         V LIL  A G+SLG E P++ +   +            L   
Sbjct: 235 SGFVIRGYLGKWTFIIKSVGLILSSASGLSLGKEGPMVHLACCIGNIFSYLFPKYGLNEA 294

Query: 143 NRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEV-PLWDRLFAPLMAAAAGALTTG 201
            + E    ++A  +   FG P+   L   +  +    +  +W   F  L+A         
Sbjct: 295 KKREILSASAAAGVSVAFGAPIGGVLFSLEEASYYFPLKTMWRSFFCALVAGIILRFVNP 354

Query: 202 LFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMK----NP 257
              +      + +  +    +++  AI+       G + ++   R        K    NP
Sbjct: 355 FGSNQTSLFHVDYMMKWTFIELVPFAILGLFGGIIGSLFIFANIRWSRFRKNSKMLGGNP 414

Query: 258 VLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQ----------------AFSTSDY 301
           +  + +   +   +     P +       +QQ+                    + +    
Sbjct: 415 IYEVMLITLVTAAI-SYFNPFTRKSAQSMIQQLFDRCEDQIDEDSLCDQNKALSIAFGQL 473

Query: 302 FLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVP-------------- 347
               + K    +         G   P++ +G   G +L   V  +               
Sbjct: 474 LWALIFKFVITIFTFGIKVPCGLFVPSIGMGAIAGRILGITVDQIFRAVQATPGHSDYFT 533

Query: 348 ---------AAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL 398
                      +        ++  VTR     + +   +  +   +    +  + +  + 
Sbjct: 534 CQIGKDCVMPGLYAMVGAAAVLGGVTRMTVSLVVIMFELTGSLEFIVPTMVATMFSKWIG 593

Query: 399 AGKPMM 404
            G   M
Sbjct: 594 DGISKM 599


>UniRef50_Q3M8F4 Cl-channel, voltage gated n=3 Tax=Cyanobacteria RepID=Q3M8F4_ANAVT
          Length = 596

 Score =  183 bits (465), Expect = 1e-44,   Method: Composition-based stats.
 Identities = 72/410 (17%), Positives = 141/410 (34%), Gaps = 23/410 (5%)

Query: 12  LSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVG 71
           +   AV IG  + + ++    +  ++ +L+ + L G +G+       +  V  L G+ VG
Sbjct: 1   MLFLAVLIGGGTGMGVVTFHYLIELIHHLMLENLMGAIGV--WGAWTLALVPILGGLIVG 58

Query: 72  LVIRFSQGHAGPDPACEPLIGAPVPPSAL--PGLIVALILGLAGGVSLGPEHPIMTVNIA 129
           L+   +Q       +             L     ++A  + L  G SLGPE P + +   
Sbjct: 59  LMRWRTQDFGPGLSSLIAASEGSEIKGQLRPVTKMLAAAVSLGSGASLGPEGPSVEIGAN 118

Query: 130 LAVAIGARLLPRVNR-MEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFA 188
             + +   L     R        +A  + A F  P+A      + + G++          
Sbjct: 119 FGMLLSLILQVSQERQRLLLGAGAAAGLAAGFNAPIAGVFFALEVVMGATSFATSAVSVV 178

Query: 189 PLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVW------ 242
            L A    AL   +      +  +  Y      ++     +   A    +          
Sbjct: 179 LLAA-VVAALIAQIGLGAQPAFALPVYQVRSPLELPLYLGLGLGASLVSVAYKQSINWGK 237

Query: 243 --CLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSD 300
              +  +       K P  +  I G  +  +  +  P  L  G   +Q M+ +  FS   
Sbjct: 238 ACFVGSIPGFQFLGKIPQPIHPIIGGFMIGIVALKFPQILGIGYGTVQAMLQDVKFSLDL 297

Query: 301 YFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAI---------T 351
             +L V+KL    ++A SGF GG   PA+F+G +LG    + +  +   I          
Sbjct: 298 LLILLVLKLLMTAISAGSGFVGGLFAPAMFLGASLGSAYAKVLTLIAPGIGEYMAAPPAY 357

Query: 352 VSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGK 401
               +  ++    R    S+ M   +  +  ++  L   +  +  L+   
Sbjct: 358 AMVGMAAVLAGSVRAPLTSILMLFELTRDYRIVLPLMAAVGLSVWLVERI 407


>UniRef50_A4BVU6 Cl-channel, voltage gated n=1 Tax=Nitrococcus mobilis Nb-231
           RepID=A4BVU6_9GAMM
          Length = 604

 Score =  183 bits (465), Expect = 1e-44,   Method: Composition-based stats.
 Identities = 68/425 (16%), Positives = 127/425 (29%), Gaps = 32/425 (7%)

Query: 2   LHPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQ---RLPGTLGIAQDSPLW 58
           L+ R     L+   AV IG+   L  I    I     NL +     L     I      W
Sbjct: 24  LNERPLPASLMFFLAVLIGVVGGLGSIAFKAIIGFFHNLFFYGEFNLNYDANIHTQPSPW 83

Query: 59  ---IIGVLTLTGIAVGLVIR-----FSQGHAGPDPACEPLIGAPVPPSALPGLIVALILG 110
              I+ V  L  + V  + R                        + P  +    +A  + 
Sbjct: 84  GIGIVLVPVLGSLIVTWITRTVAPEARGHGVPEVLHAIYYGQGRIRPVVVIAKAIASSVT 143

Query: 111 LAGGVSLGPEHPIMTVNIALAVAIGARLLPRVNRM-EWTILASAGTIGALFGTPVAAALI 169
           +  G S+G E PI+ +  A    +G       ++        +A  I A F  P+     
Sbjct: 144 IGTGGSVGREGPIVQIGSAFGSIVGQLTRLPAHQRVVLISAGAAAGIAATFNAPIGGLAF 203

Query: 170 FSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQME-----MTDIL 224
             + L  S             +A       +  +     S  +      E        +L
Sbjct: 204 AIELLLVSISARTVAL---VAIATVTATYISHFYSGLLPSFDVPSLAVFENHIIGFYTLL 260

Query: 225 SGAIVAAIAIAAGMVAVWCLPRLHAMM-HQMKNPVLVLGIGGFILGILGVIGG-----PV 278
               +  +   A    +  +  +     H  +N  +    G F +G++  +         
Sbjct: 261 LCIPLGILLGFASSAFIRFIYYMEDWFDHHFRNDYVRHMCGMFAVGVMLYLFLRYSGQYY 320

Query: 279 SLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLM 338
               G   +   +       +   LL + KL A  +   SG  GG   P++F+G  LG  
Sbjct: 321 IGGVGYATVMDTLRRTLSDPAFLALLFLAKLLATGLTLGSGGSGGVFSPSLFLGATLGAA 380

Query: 339 LHEHV------PAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVML 392
                        +   + V   + G+V   T     ++ M      + + +  +   + 
Sbjct: 381 FGNFFALIIPEAGIDPVVFVVAGMAGMVSGSTGAVLTAITMLFEQTRDYSAMLPIITTVA 440

Query: 393 PAWLL 397
            A+++
Sbjct: 441 LAYVV 445


>UniRef50_Q2RI45 Cl-channel, voltage gated n=1 Tax=Moorella thermoacetica ATCC 39073
           RepID=Q2RI45_MOOTA
          Length = 539

 Score =  183 bits (464), Expect = 1e-44,   Method: Composition-based stats.
 Identities = 63/392 (16%), Positives = 130/392 (33%), Gaps = 21/392 (5%)

Query: 30  VMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRFSQGHAG----PDP 85
                +         L    GI     L +  +  L G   G +   +   AG       
Sbjct: 46  FRLALTEGDLWRNSLLTWAKGIPLWGWLALPFLGALAGGLAGWLTSLAPETAGSGIPHVE 105

Query: 86  ACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARL-LPRVNR 144
           A    +   V    +P   +A  L +  G+SLGPE P + +  A   A+       +   
Sbjct: 106 AVLINLRRLVWWRVIPVKFIAGALAIGAGLSLGPEGPAVQMGAAAGKAVSDGFGRSKTEE 165

Query: 145 MEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFF 204
           +      +   + A F  P+A  +   + L  +        L   L+A+    + +    
Sbjct: 166 LHLIACGAGAGLAAAFNAPLAGVVFVLEELRRNFSPY---ALGGALVASVVADMVSRHIL 222

Query: 205 HPHFSLPIAH-YGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQM-KNPVLVLG 262
            P  +  +   +  + +T +    ++  +A   G V  W L     +  ++ + P  +  
Sbjct: 223 GPLPTFRLIEAWPVLPLTTLPVFLVLGVLAGILGAVFNWSLLASLELGDRLNRFPRWLRA 282

Query: 263 IGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRG 322
           +    L  +     P  L  G    ++ +A +  + +   LL V+K    +++ ++G  G
Sbjct: 283 LLILFLAGILGYFLPEVLGGGHLLAEEALAGK-VAWTLIPLLFVVKFLLTMISNSAGVPG 341

Query: 323 GRI--------FPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLVVTRDGWLSLFMA 374
           G               VG   GL++      VPA       +    + + R     + + 
Sbjct: 342 GIFLPLLVLGALLGSLVGQVSGLLIPAFQGMVPA--FAMIGMAAYFVAILRLPLTGVVLI 399

Query: 375 AVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMV 406
             +  +   + LL    + A+L++        
Sbjct: 400 IEMTGSYRHIVLLLFTCMIAYLVVETLGSRPA 431


>UniRef50_D2QHH8 Cl-channel voltage-gated family protein n=1 Tax=Spirosoma linguale
           DSM 74 RepID=D2QHH8_9SPHI
          Length = 452

 Score =  183 bits (464), Expect = 1e-44,   Method: Composition-based stats.
 Identities = 57/403 (14%), Positives = 127/403 (31%), Gaps = 19/403 (4%)

Query: 8   TMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTG 67
           ++L     A  IG    ++    +     +               Q    W+     +  
Sbjct: 12  SVLKWLFIASLIGCVVGVVASGFILSLHYIIE--------QSNQYQHIFYWLPVSFFVAN 63

Query: 68  IAVGLVIRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVN 127
           +    V++   G               +  S +P  +V ++L LA G S G E P   + 
Sbjct: 64  LLSQFVLKRHLGTDA-LIDAINKNYGKLEGSFIPTKVVNVVLILATGGSAGKESPCAQIG 122

Query: 128 IALAVAIGARLLPRV-NRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRL 186
             +             +R +  +         +FG P+A AL   + L  +  V ++D L
Sbjct: 123 AGIGSVCANLFRVDDIDRRKMVLCGFCAGFACVFGAPMAGALFGIEVL--AVGVIVYDVL 180

Query: 187 FAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPR 246
               +A+      + +     F  P+           +                V  + +
Sbjct: 181 LPAFVASVTAYQVSSVLGVTFFYYPLTFIPAFGQGFFIQLLAGGIFFGLCAYALVRAIQQ 240

Query: 247 LHAMMHQMKNPVLVLGIGGFIL-GILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLA 305
                + +     + G+ G I+   L ++     L  GL+ M+  +     S        
Sbjct: 241 STQATNAIPLWRPLKGLLGGIILVGLTLLFSRDYLGLGLNLMEDCIKGIHVSG----YAF 296

Query: 306 VIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITVSCAILGIVLVVTR 365
           ++K    ++  +    G  I P +F+G   G    + V A   +   +   + ++   T 
Sbjct: 297 LLKALFTIITLSISRSGSVITPVLFIGATAGSFFSQLVGADQ-STFAAIGFVSLLAGTTN 355

Query: 366 DGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNR 408
               +  +A  +    ++ P   +  + ++L+   + +    R
Sbjct: 356 TPIATSMLAIELFG-ASVAPYAAVSCVLSYLMSGHQSLYASQR 397


>UniRef50_Q47VA1 Voltage-gated chloride channel n=2 Tax=Alteromonadales
           RepID=Q47VA1_COLP3
          Length = 574

 Score =  183 bits (464), Expect = 1e-44,   Method: Composition-based stats.
 Identities = 65/403 (16%), Positives = 137/403 (33%), Gaps = 14/403 (3%)

Query: 7   RTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLT 66
           +T   + L A+  G AS+L++++       +Q L   +      + + S   +  + +L 
Sbjct: 16  KTSWQICLLAIIGGAASALLVVLFTLTIEEIQQLYLIKRDNYNSLDEVSRFHLPIIGSLI 75

Query: 67  GIAVGLV--IRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIM 124
            + +  +   ++ +           +    +P            + LA G S+G E P +
Sbjct: 76  ILLMAWLTGYKYIRTGIPFVLHRLKVAHGIIPFKNTLNQFWGSAVALASGFSVGREGPAV 135

Query: 125 TVNIALAVAIGARLLPRVNR-MEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLW 183
            +  A +  +G+ L    N          A  I A F TP+AA +   + +    +    
Sbjct: 136 HLGAACSSYLGSVLKLPYNSTRTLCACGIAAGIAATFNTPIAAVIFVMEVVMREYKA--- 192

Query: 184 DRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWC 243
                 ++A+  G+L T   F    +    +   +E     S  ++A +           
Sbjct: 193 HVFVPVMLASIVGSLITRSVFGTSHNFQHFNTIALEQQHYFSLILLAIVLGILAAAFNKY 252

Query: 244 LPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFL 303
           L  +  +   +K  ++   I   ++        P ++  G   +   + N        F 
Sbjct: 253 LVVI--IKKSVKYHIVPRLILAALITGTLGYLVPGAMGTGTSAIDISLTNN-LPLGFLFS 309

Query: 304 LAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPA-----AITVSCAILG 358
           L + KL   + A   G  GG I P + +G   G ++   V  V       +  +   + G
Sbjct: 310 LLIAKLLMTMFALGLGIPGGIIGPTISIGAITGALVGAVVIQVLPGEHVSSDFILMGMAG 369

Query: 359 IVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGK 401
            +         +L     +     L+    IV+  A ++    
Sbjct: 370 FMAASLNAPLATLLAVVELSGQLELVVPAMIVITIASIVSRQL 412


>UniRef50_B3DNT2 Chloride channel protein n=16 Tax=Bacteria RepID=B3DNT2_BIFLD
          Length = 527

 Score =  183 bits (464), Expect = 1e-44,   Method: Composition-based stats.
 Identities = 65/402 (16%), Positives = 128/402 (31%), Gaps = 19/402 (4%)

Query: 10  LLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIA 69
             ++   + IG+ S L+++V         +                  W +  +      
Sbjct: 22  WKMAAAGIVIGLVSGLLVVVYRLGIEYGTDASRWIYARIRETPWLIAPWAVAAVAAALAI 81

Query: 70  VGLVIRFSQGHAGPDPACEPLIGAPVPPSA---LPGLIVALILGLAGGVSLGPEHPIMTV 126
             +V +         P    ++   +       LP   V  +LG   G+SLG E P + +
Sbjct: 82  AWMVGKEPMAGGSGIPQTNGVVICGLKMRWQTILPVRFVGGLLGALFGLSLGREGPSIQI 141

Query: 127 NIALAVAIGARLLPRV----NRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPL 182
             + A  +  RL  R              +A  + A F  P++  +   + ++ S     
Sbjct: 142 GASGAQCVSHRLRGRRREDMQEHYLVTAGAAAGLSAAFSAPLSGMMFALEGVHRSFSPA- 200

Query: 183 WDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVW 242
              L     A+      +   F     L     GQ+ + + +    +  +A   G +   
Sbjct: 201 --ILMGATAASLTADFVSKYCFGLRPVLDFGDIGQLSLEEYVWLIPLGLVAGLVGSLMNR 258

Query: 243 CLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYF 302
            L     +  ++  P     +    + +   I  P  L  G + +     +         
Sbjct: 259 SLLGFQTLYGKL--PAWSRPMIAIAIALPVGIWLPDVLGGGSNLIDTA-EHARVGLGMLC 315

Query: 303 LLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEH------VPAVPAAITVSCAI 356
           LL V K+     +  SG  GG   P + VG   G +  E       +P+   A+   C +
Sbjct: 316 LLFVAKMLFTSTSFGSGAPGGIFMPILAVGSLAGGICGEVLHRFGDLPSDAVAVFAVCVM 375

Query: 357 LGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL 398
            G +    +    S+ +A  +    T +  +  V   A L+ 
Sbjct: 376 TGTLAASVKTPITSILLAVEMSGTLTHMLPVAAVAFIALLVS 417


>UniRef50_A5G2G7 Cl-channel, voltage-gated family protein n=1 Tax=Acidiphilium
           cryptum JF-5 RepID=A5G2G7_ACICJ
          Length = 606

 Score =  183 bits (464), Expect = 2e-44,   Method: Composition-based stats.
 Identities = 73/406 (17%), Positives = 138/406 (33%), Gaps = 19/406 (4%)

Query: 10  LLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDS---PLWIIGVLTLT 66
           + L++ A  +G+ S   + ++  ++       +       G++Q +   PL  I V  L 
Sbjct: 42  IWLAMLAAVVGVLSGFCVYLMDFLSHHFHFWFFALPNLDEGLSQQTHIDPLRAIFVPILG 101

Query: 67  GIAVG----LVIRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHP 122
           G  +G    L+ R+   +         L G  +       + +        G S+G E  
Sbjct: 102 GAVLGSVAWLLGRYRMTNFVDPVEANALYGGKMSLRDSIIVAMQTSFSNGVGGSVGQEAG 161

Query: 123 IMTVNIALAVAIGARLLPRVNR-MEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVP 181
                  LA  +G  L  R N         +   IG  F  P+  A    + + G+  +P
Sbjct: 162 YAQFGGGLASWVGQHLRLRRNDLRVLVGCGAGAAIGGAFNAPLCGAFYGIELVIGTYSLP 221

Query: 182 LWDRLFAPLMAAAAGALTTGLF-FHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVA 240
               L   ++++ +G L   L        L +               ++  IA   G+  
Sbjct: 222 ---TLTMVVISSLSGTLAVELLMNGGVRPLNVVLPTHTPGYAYPLAVLLGIIAGFVGIAI 278

Query: 241 VWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSD 300
           +  +  L A+  +   P+ +  I G ++  L     P  +  G   +   +A   +    
Sbjct: 279 MRAVTSLEAVFRRTGVPIWLRPIIGGVVVGLLGSITPKVMASGNSSLHTQLA-VVYPFML 337

Query: 301 YFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLH------EHVPAVPAAITVSC 354
              L V+K  A   + A+GFRGG  F A+F+G  LG               VP       
Sbjct: 338 AVALLVMKSTASAFSIATGFRGGLFFAALFMGSLLGRAYGDVAVMLPFAHGVPIGFYAVV 397

Query: 355 AILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAG 400
            +  +   +        F+      N ++   + +  + A L +  
Sbjct: 398 GMAALATSIVSGTMTMTFLTLESTNNFSITIAVLMAAIAASLTVRR 443



 Score = 42.5 bits (99), Expect = 0.034,   Method: Composition-based stats.
 Identities = 38/201 (18%), Positives = 70/201 (34%), Gaps = 19/201 (9%)

Query: 15  PAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVI 74
            AV +GI +  + I +M+  + L+ +            + + + I     + G+ VGL+ 
Sbjct: 263 LAVLLGIIAGFVGIAIMRAVTSLEAVF-----------RRTGVPIWLRPIIGGVVVGLLG 311

Query: 75  RFSQGHAGPDPACEPLIGAPVPPSALPGLIV-----ALILGLAGGVSLGPEHPIMTVNIA 129
             +        +      A V P  L   ++     A    +A G   G     + +   
Sbjct: 312 SITPKVMASGNSSLHTQLAVVYPFMLAVALLVMKSTASAFSIATGFRGGLFFAALFMGSL 371

Query: 130 LAVAIGAR-LLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFA 188
           L  A G   ++            +   + AL  + V+  +  + T         +    A
Sbjct: 372 LGRAYGDVAVMLPFAHGVPIGFYAVVGMAALATSIVSGTM--TMTFLTLESTNNFSITIA 429

Query: 189 PLMAAAAGALTTGLFFHPHFS 209
            LMAA A +LT   FF   F+
Sbjct: 430 VLMAAIAASLTVRRFFGYSFT 450


>UniRef50_C6I4K1 Voltage-gated chloride channel protein n=31 Tax=Bacteroidales
           RepID=C6I4K1_9BACE
          Length = 523

 Score =  183 bits (464), Expect = 2e-44,   Method: Composition-based stats.
 Identities = 57/417 (13%), Positives = 132/417 (31%), Gaps = 21/417 (5%)

Query: 11  LLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAV 70
            L   ++ +G+ + L+ +    +      L +                I   L+L GI +
Sbjct: 25  RLYFVSIFVGLLTGLVAVPYHYLL----QLFFNTRRDFFDSHPHWYWHIPIFLSLWGILL 80

Query: 71  ---GLVIRFSQGHAGPDPACEPLIGAPVPPS----ALPGLIVALILGLAGGVSLGPEHPI 123
               LV +      G  P    +I   +        L    V  +L L+ G+SLG E P 
Sbjct: 81  FVMWLVKKMPLITGGGIPQTRGVINGRISYKHPFIELVSKFVGGVLALSAGLSLGREGPS 140

Query: 124 MTVNIALAVAIGA--RLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVP 181
           + +   +   +    R+L    +      A AG   A      ++ L+        +   
Sbjct: 141 VQIGSYVGCLVSKWGRVLAGERKQLLAAGAGAGLAAAFAAPLASSLLVIESIERFDAPKT 200

Query: 182 LWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAV 241
               L A ++A    ++   +  +P+F +     G    + +    ++AA+   +G +  
Sbjct: 201 AITTLLAGVVAGGVASMIFPI--NPYFQIDAISPGLTFFSQVKLFLLLAAVISVSGKIYS 258

Query: 242 WCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDY 301
                   +   +K+P  V  +    +  L  +        G   +     +        
Sbjct: 259 VITVWFKRLYPAIKHPAYVKMLYLLFIAYLISLTEVNLTGGGEQFLLGQAMHADTHIMWI 318

Query: 302 FLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHV------PAVPAAITVSCA 355
             + ++     V++ +SG  GG   P +  G  +G ++   +           +  +   
Sbjct: 319 VGMMILHFVFSVLSFSSGLPGGSFIPTLVTGGLIGQIVALILVRQGIIGYENISYVMLIC 378

Query: 356 ILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMMVNRPKQQ 412
           +   ++ V R    ++ +   +  +  +     +V    +       +   N     
Sbjct: 379 MSAFLVAVIRTPLTAIVLITEITGHLEVFYPSIVVGGLTYYFTEMLQIQPFNVTLYD 435


>UniRef50_B2VX85 Chloride channel protein 3 n=17 Tax=Dikarya RepID=B2VX85_PYRTR
          Length = 908

 Score =  182 bits (463), Expect = 2e-44,   Method: Composition-based stats.
 Identities = 56/462 (12%), Positives = 123/462 (26%), Gaps = 74/462 (16%)

Query: 13  SLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTL--------------------GIA 52
            +    +G A  L    +  +   L ++                                
Sbjct: 168 WIVVTLVGAAIGLNAAFLNIVTEWLSDIKLGHCSTAFYLNESFCCWGAEGGCAEWKRWTG 227

Query: 53  QDSPLWIIGVLTLTGI---AVGLVIRFSQGHAGPDPACEP------LIGAPVPPSALPGL 103
                +++ +L        A  LV  F+   AG   +         ++   +  + L   
Sbjct: 228 FWPANYLMYILFAALFSFTAARLVKSFAPYAAGSGISEMKCIIAGFVMKGFLGFTTLFIK 287

Query: 104 IVALILGLAGGVSLGPEHPIMTVNIALAVAIGARL----LPRVNRMEWTILASAGTIGAL 159
            + L L +  G+S+G E P +   +     I               E    ++A  +G  
Sbjct: 288 SIGLPLAIGSGLSVGKEGPSVHYAVCTGNVISRFFDKYRRNAAKTREILSASAAAGVGVA 347

Query: 160 FGTPVAAALIFSQTLNGSSEV-PLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQM 218
           FG+P+   L   + ++    +  LW   F  L+A A  A              + +    
Sbjct: 348 FGSPIGGVLFSLEEMSNQFPLKTLWRSYFCALVATAVLAAMNPFRTGQLVMFNVKYDRSW 407

Query: 219 EMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPV 278
              + +   ++       G   +    ++     +      +       + + GVI  P 
Sbjct: 408 HFFETVFYILIGVFGGLYGAFVIKWNLKMQVFRKKYMAAYPITEAVTLAV-VTGVICYPN 466

Query: 279 SL------------------FKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGF 320
                                KG D +     ++  +     +  VI+   +V++     
Sbjct: 467 MFLRIDMTESMEILFQECKAGKGYDRLCDQ-NHKWHNIGTLAIATVIRTLLVVISFGCKV 525

Query: 321 RGGRIFPAVFVGVALGLMLHEHVPAVP--------------------AAITVSCAILGIV 360
             G   P++ +G A G M+   V A+                                 +
Sbjct: 526 PAGIFVPSMAIGAAFGRMVGICVQALHEAFPTSAFFAACEPDVACITPGTYAFLGAAASL 585

Query: 361 LVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKP 402
             +       + +   +    T +    IV+     +     
Sbjct: 586 SGIMHITVSVVVIMFEITGALTYILPTMIVVGVTKAVSERFG 627


>UniRef50_C3JN09 Cl-channel, voltage-gated family protein n=2 Tax=Rhodococcus
           erythropolis RepID=C3JN09_RHOER
          Length = 459

 Score =  182 bits (463), Expect = 2e-44,   Method: Composition-based stats.
 Identities = 54/396 (13%), Positives = 120/396 (30%), Gaps = 18/396 (4%)

Query: 31  MKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRFSQGHAGPDPACEPL 90
                    L    +     +     L  + ++ L  +   L++R      G        
Sbjct: 58  RWCLIRADELRQAIVNWAHHVPYVGWLVPVLLVALCTVLAVLIVRRVPLAKGSGIQHVEA 117

Query: 91  IGA----PVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARLLPRV-NRM 145
           +      P   + +P   +  +L +  G+ LG E P + +  A+    G R      +  
Sbjct: 118 VSRGEAKPPGINLVPARFIGGLLAIGSGLVLGREGPTVHMGAAIGAEAGRRARLTEPDVA 177

Query: 146 EWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFH 205
                 +   +   F  P+A AL   + +  S  +     +   L   +       +   
Sbjct: 178 MLQTSTAGAGLAVAFNAPIAGALFVCEEVTHSFRL---RTVLPTLFGVSVAVGCARIVIG 234

Query: 206 PHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQM-KNPVLVLGIG 264
                 +      ++  +    +   +    G+     +  L  ++ ++ K P  V+G  
Sbjct: 235 DQPDFEVGTVPTPQLALLPLFVVFGILTGLLGIAYNRLILGLLDIVARLDKIPPTVIGAT 294

Query: 265 GFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGR 324
              +  L +   P++   G    Q +V  + F      L  V++     ++ A+G  GG 
Sbjct: 295 IGAVIGLTLFLDPLASGGGDVLAQMIVGGRTFVLPILLLYLVVRFFTGPLSYAAGTPGGL 354

Query: 325 IFPAVFVGVALGLMLHEHVPAVPAAIT------VSCAILGIVLVVTRDGWLSLFMAAVVV 378
             P + +G   G +       VP           +  +      V R  +  + +   + 
Sbjct: 355 FAPLLALGALWGSIFTGLSSFVPGVGAELTITMATVGMAAFFGAVVRAPFTGVVIVVEMT 414

Query: 379 PNTTLLPLLC---IVMLPAWLLLAGKPMMMVNRPKQ 411
             T+ L  +       +    L    P+    R + 
Sbjct: 415 AVTSTLVPMLAATAAAVFVTTLAGSAPIYDSLRERM 450


>UniRef50_A3ZLX7 Chloride channel protein n=1 Tax=Blastopirellula marina DSM 3645
           RepID=A3ZLX7_9PLAN
          Length = 449

 Score =  182 bits (463), Expect = 2e-44,   Method: Composition-based stats.
 Identities = 70/430 (16%), Positives = 131/430 (30%), Gaps = 43/430 (10%)

Query: 10  LLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIA 69
           L      + +GI     + + +    V+  L W               W++ +L L GIA
Sbjct: 18  LKWLAICLPLGIVVGSSVAIFLWALHVVTLLQWDNS------------WLLYLLPLAGIA 65

Query: 70  VGLVIRFSQGHA----GPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMT 125
            GL+  +    A              G  VP    P +++  ++    G S G E   + 
Sbjct: 66  SGLMYHYLGREAEAGNNLIMEQIHQPGGGVPLRMAPLVLIGTLITHLFGGSAGREGTAVQ 125

Query: 126 VNIALAVAIGARLLPRVNR-MEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWD 184
           +  +LA  +G  L    +          A   GA+FGTP+  A+   + +  +     + 
Sbjct: 126 MGGSLAGVLGRLLKLTPDETRILLSAGVAAGFGAVFGTPLTGAIFAVEVI--AIGKMSYK 183

Query: 185 RLFAPLMAAAAGALTTGLFFHPHFSLPIA---------HYGQMEMTDILSGAIVAAIAIA 235
            L   L+A+  G      +   H    I              ++       AI A     
Sbjct: 184 ALIPCLLASVIGDQVNTAWGIGHTHYHIGFAAEISSSLSAVSLDWALTGKVAIAAIFFGL 243

Query: 236 AGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQ------ 289
           A ++       +     +      +    G  + I  V       + GL           
Sbjct: 244 ASVLFAELTHAISGTAKRFIAIPWLRPAVGGCVVIALVWLLGTRDYLGLGVTPHPPDSGM 303

Query: 290 -MVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPA 348
             + +        ++    KL    V   SGF+GG + P  F+G ALG +    +   P 
Sbjct: 304 ICIESCFQPGGADWMSWWWKLLFTAVTVGSGFKGGEVTPLFFIGAALGNVTGVML-GAPV 362

Query: 349 AITVSCAILGIVLVVTRDGWLSLFMAAVVVP-------NTTLLPLLCIVMLPAWLLLAGK 401
            +      + +    T        MA  +         ++  +    I    ++ L    
Sbjct: 363 DLMAGLGFVAVFAGATNTPLACTIMAIELFGPGNGELLSSGFVVYAAIACFLSYFLSGSS 422

Query: 402 PMMMVNRPKQ 411
            +    +  +
Sbjct: 423 SIYQAQKRDE 432


>UniRef50_Q6BNC8 DEHA2E22814p n=2 Tax=Debaryomyces hansenii RepID=Q6BNC8_DEBHA
          Length = 1073

 Score =  182 bits (462), Expect = 2e-44,   Method: Composition-based stats.
 Identities = 45/403 (11%), Positives = 110/403 (27%), Gaps = 70/403 (17%)

Query: 81  AGPDPACEPLIGAPVPPS-----ALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIG 135
               P  + ++   V         L    +ALI  +A G++LG E P + +  A+   + 
Sbjct: 388 GSGVPEVKTILSGFVIRRFLGTYTLFAKTIALIFAIASGMALGKEGPYVHLATAVGNIMT 447

Query: 136 ARLLPRVN----RMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEV-PLWDRLFAPL 190
                  N    + +    +++  +   FG+P+   L   + +N       L+   F  +
Sbjct: 448 RFFPYINNNDFMKKQILSASASSGVALAFGSPLGGVLFILEEINHYLPSHQLFQIFFCAI 507

Query: 191 MAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAM 250
           ++                   + +       +++   I+       G + V  +      
Sbjct: 508 ISTLFLKFLNPYGTGNTVLFELKYTSDWNAVELIFFIIIGISGGIFGGLFVRFVGWWPKK 567

Query: 251 MHQMK----NPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFS--------- 297
             Q+K    +P++ +     + G++     P +     + +  +  +             
Sbjct: 568 FRQLKMIKNHPIIEVFFISLLTGLIT-FWNPYTKQASSELVLDLATSCNSQGLDSSLCPV 626

Query: 298 --------TSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPA---- 345
                           V+K+    +        G   P++ +G   G      +      
Sbjct: 627 THEQFVKELGSLIFALVVKMVLTCLTFGLKLPCGIYVPSMVIGALYGRTFAMFIQWSNYK 686

Query: 346 -------------------------------VPAAITVSCAILGIVLVVTRDGWLSLFMA 374
                                          V   I    +    +  +TR     + + 
Sbjct: 687 YNLNLGDEGASAPSTSLMRFICSPDSSNNECVDLGIYSMISAGAFMAGITRMNITLVTIL 746

Query: 375 AVVVPNTTLLPLLCIVMLPAWL---LLAGKPMMMVNRPKQQPP 414
             +  + T +  + I +  A     L+  K +          P
Sbjct: 747 FELTSSYTYVLPISISISVANWSGSLIEKKSLYESLLVSNDYP 789


>UniRef50_D1NB42 Cl-channel voltage-gated family protein n=1 Tax=Victivallis
           vadensis ATCC BAA-548 RepID=D1NB42_9BACT
          Length = 609

 Score =  182 bits (462), Expect = 2e-44,   Method: Composition-based stats.
 Identities = 62/425 (14%), Positives = 133/425 (31%), Gaps = 34/425 (8%)

Query: 5   RARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLT 64
           R     L+ + A+ IG  +++   ++  +   L+            + + +   ++ +L 
Sbjct: 28  RWGERSLIVVLAICIGGVAAVAAALLHTLVVKLELFGIWLTQAPKQVHEYAWFAVLFILP 87

Query: 65  LTGIAVGLVIRFSQGHA------GPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLG 118
           + G+    V++   G         P           +P   +   +++  + +  G S G
Sbjct: 88  MLGLLGSFVVQRFLGGPRYAKSLSPLILALNRKRTNIPAVEMINHMLSSAISVGFGGSAG 147

Query: 119 PEHPIMTVNIALAVAIGARLLPRVNRM-EWTILASAGTIGALFGTPVAAALIFSQTLNGS 177
            E P +    A+     + L              SA  I A+F +P+A  L  ++ L   
Sbjct: 148 LEAPSVLTGAAIGANSASFLHIDRRHRSLLLGCGSAAAISAIFDSPIAGVLFAAEVLLPE 207

Query: 178 SEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAG 237
             V     L   +M++A  A+ +           +A     +   +    +        G
Sbjct: 208 FSV---SALVPMMMSSAVAAVVSRQIMGD-TQFILAINAPWQANAVPCYFLCGIFCALVG 263

Query: 238 MVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFS 297
           +  +         +             G  +  + ++  P+   +G   ++++ A     
Sbjct: 264 VYVIKTAYFTGDWLKHKFRNAWQRLFVGGSVLCVLLLLFPMMRGQGYLYIEKLFAGDTAG 323

Query: 298 TSDYFLLAVIKLAALVV------------------AAASGFRGGRIFPAVFVGVALGLML 339
                 L     +   +                     +G  GG   P++F+G   G + 
Sbjct: 324 LVASSPLLHWIPSETGILVLLLVVVLLLKVVVSVLTVDAGGDGGIFAPSMFIGAFAGFVF 383

Query: 340 HEHVP-----AVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPA 394
              V       +     V+  + G+   V R     +F+ A V  +  LL  L IV   A
Sbjct: 384 ARVVNLTGLIQLQEYNFVAVGMCGVFTAVMRAPLTGIFLIAEVTGSYILLVPLMIVSSVA 443

Query: 395 WLLLA 399
           W    
Sbjct: 444 WFTAR 448


>UniRef50_A5DRV5 Putative uncharacterized protein n=1 Tax=Lodderomyces elongisporus
           RepID=A5DRV5_LODEL
          Length = 912

 Score =  181 bits (461), Expect = 3e-44,   Method: Composition-based stats.
 Identities = 44/391 (11%), Positives = 101/391 (25%), Gaps = 55/391 (14%)

Query: 79  GHAGPDPACEPLIGAPVPPS-----ALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVA 133
            +    P  + ++   V         L     ALI  +A G+SLG E P + +   +   
Sbjct: 285 ANGSGVPEVKTILSGFVIRRFLGVYTLIAKTAALIFAIASGMSLGKEGPYVHLATCVGNI 344

Query: 134 IGARL----LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVP-LWDRLFA 188
                           +    +++  +   FG+P+   L   + +N       L+   F 
Sbjct: 345 TSRYFPFIYKNDFFEKQILSASASAGVALAFGSPLGGVLFILEEINNYLPSHHLFQVFFC 404

Query: 189 PLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLH 248
            +++                   + +    +  +++   ++     A G   V  +    
Sbjct: 405 AIISTLFLKFLDPYGTGKTVLFELEYSSDWKPIELVFFVLIGMSGGAFGAAFVKFVNWWP 464

Query: 249 AMMH---QMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFS-------- 297
                   +KN  L        L  +     P +     + +  +  + +          
Sbjct: 465 KKFRTKRWIKNNPLFEVFLVAALTGIVTFWNPYTKQASAELILDLATSCSGGEPDRSLCP 524

Query: 298 ---------TSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPA 348
                            ++KL    +        G   P++ VG   G +L   +  +  
Sbjct: 525 TTRDQYISEIVSLLTAFIVKLVLTFITFGLKLPCGIYVPSMVVGALYGRVLAMCIQFIGL 584

Query: 349 ----------------------AITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPL 386
                                  I    +    +  VTR     + +   +  + T +  
Sbjct: 585 ILKDTSTLSFMCMPNSTNCVDMGIYAMISAGAFMAGVTRMNITIVTILFELTSSYTYVLP 644

Query: 387 LCIVMLPAWLLLA---GKPMMMVNRPKQQPP 414
           + I +  A           +          P
Sbjct: 645 ISIAIAVANWFGGLFEKNSLYESLLIANDYP 675


>UniRef50_Q045T1 Chloride channel protein EriC n=19 Tax=Lactobacillus
           RepID=Q045T1_LACGA
          Length = 457

 Score =  181 bits (460), Expect = 4e-44,   Method: Composition-based stats.
 Identities = 66/408 (16%), Positives = 131/408 (32%), Gaps = 28/408 (6%)

Query: 30  VMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLT---GIAVGLVIRFSQGHAGPDPA 86
              I       L+   P           +II  L +    G  +  V+    G   P   
Sbjct: 38  FRWIIDHTMKFLFFIYPLMRQKPIYLVPYIIITLLIVLILGKIIKPVLSNITGSGVPQVE 97

Query: 87  CEPLIGAPVPPSA-LPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARLLP--RVN 143
              L    +   + L    V  +L +  G+ LG E P + +   +  A G  L      +
Sbjct: 98  AVMLNENKMNWWSILWRKFVGGLLAICPGLFLGREGPCIQMGAMVGQAFGEDLFHADPDD 157

Query: 144 RMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLF 203
                    A  + A F  P+A      + +  +        + + L AA +  L T  F
Sbjct: 158 FKRLQGCGIAAGLSAAFSAPLAGVFFLVEEITFNFTPKE---VLSALAAAMSSDLMTLCF 214

Query: 204 FHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQM-KNPVLVLG 262
           F     L +     + +T     AI+  +      +  +CL  L  +  ++ K P +   
Sbjct: 215 FGTQPCLYLPLDKSLPLTSYWFVAIIGVVLGLLAYLYQYCLLSLKPVYAKITKIPAIYHS 274

Query: 263 IGGFILGILGVIGGPVSLFKGLDEMQQMV---------ANQAFSTSDYFLLAVIKLAALV 313
           I   +L I   +     L    D +  +                     +  V++    +
Sbjct: 275 IIPLLLVIPIGLWNANLLGGSHDFISSLFDPIFMKSIQTGTLSLMLLPLVWFVVRFIFSM 334

Query: 314 VAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAA------ITVSCAILGIVLVVTRDG 367
           ++  +   GG   P + +G  LG++    +     A      I +  ++      + +  
Sbjct: 335 ISYGASVPGGIFMPILVLGALLGVVFAVLMIHFNIAPKRCYGIIIVTSMCAYFGAIEKAP 394

Query: 368 WLSLFMAAVVVPNTTLLPLLCIVMLPAWLL---LAGKPMMMVNRPKQQ 412
           + +L +   +V +   +  + I    A+ +   L GKP+    R +  
Sbjct: 395 FTALTLLTEMVGSVEQIFPMLITTFIAYFVLDLLGGKPIYAALRYQMD 442


>UniRef50_A5FTY4 CBS domain containing protein n=15 Tax=Bacteria RepID=A5FTY4_ACICJ
          Length = 634

 Score =  181 bits (460), Expect = 4e-44,   Method: Composition-based stats.
 Identities = 65/406 (16%), Positives = 131/406 (32%), Gaps = 17/406 (4%)

Query: 6   ARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRL-------PGTLGIAQDSPLW 58
            R +  L       G+   +   +++++  ++ +L +  +       PG         LW
Sbjct: 20  DRGIFRLIGFGACAGLFGVIAGWILLRMIGLINDLAYYGVWSTRMLAPGGAAPGGHPALW 79

Query: 59  IIGVLTLTGIAVGLVIRFS-----QGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAG 113
            I V     +A+GL+ R+                  L GA +         ++  + +  
Sbjct: 80  TILVPAGGAVAIGLMARYGSEKIRGHGIPEAIEAILLGGARLDLRVAILKPISSAISIGT 139

Query: 114 GVSLGPEHPIMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQ 172
           G   G E PI+    A A  +     L    R    +  +   + A+FGTP         
Sbjct: 140 GGPFGAEGPIIMTGGAAASLMAQCFTLTDAERKTLLVAGACAGMTAVFGTP---VAALLL 196

Query: 173 TLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAI 232
            +           +     A    A+   L   P    P A    ++    L    +   
Sbjct: 197 AVELLLFELKPRSIIPVATACITAAILRRLCMTPAPLFPYAGGVIVDPLHALGWLGLGLA 256

Query: 233 AIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVA 292
           A     +    +         +    +   + G ++  +G +  P +L  G  ++ +++A
Sbjct: 257 AGLGSALLTVLVYAAEDGFETLPIHWMWWPVLGGLVVGIGGVFDPAALGVGYPDIARLLA 316

Query: 293 NQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAITV 352
               +      L ++K     VA  SG  GG + P + +G ALG +L   +P        
Sbjct: 317 GT-LAGGAAIRLVLVKGVIWSVALGSGTSGGVLAPLLIIGGALGAVLAPVMPHAAPGFWA 375

Query: 353 SCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL 398
              +  ++    R    S   A  +  N  +L  +    + +  + 
Sbjct: 376 VLGMAAMMGGTMRAPLTSTLFAVELTGNHLILLPVLAASMASMAVT 421


>UniRef50_Q3IHP9 Putative Voltage-gated ClC-type chloride channel clcA n=3
           Tax=Alteromonadales RepID=Q3IHP9_PSEHT
          Length = 560

 Score =  181 bits (460), Expect = 4e-44,   Method: Composition-based stats.
 Identities = 62/422 (14%), Positives = 131/422 (31%), Gaps = 18/422 (4%)

Query: 5   RARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLT 64
           + +T + L L  V+ G+ ++  +I+        Q++  +       +     + +  +  
Sbjct: 12  KPKTSVQLCLLGVSAGLIAAFFIILFRLTILFFQSIFLETPDDFTTLPTLERVLMPLIAA 71

Query: 65  LTGIAVGLV--IRFSQGHAGPDPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGPEHP 122
           L           +  +                +P        V   L L  G S+G E P
Sbjct: 72  LLIAFFAAFTGFKHYRLGIPFVIHRIKRHYGQMPLYNTLNQFVGGALALISGFSVGREGP 131

Query: 123 IMTVNIALAVAIGARL-LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVP 181
            + +    A  +  +L LP       +    A  I A F TP+AA +   + +    +V 
Sbjct: 132 SVHLGATGASILATKLHLPHNAMRTLSGCGIAAGIAASFNTPLAAVIFVMEVVLREYKV- 190

Query: 182 LWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAV 241
                   ++AA  GAL T   F     L +     +         +      A      
Sbjct: 191 --HIFVPIMLAAVTGALATQFVFGEGSELALISIAPLSGWHYPYLILCGMALGAIAYSFN 248

Query: 242 WCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDY 301
             L  +          +    +    +  L     P ++  G+  +  +           
Sbjct: 249 QNLMLIIKTFK--PLSMFPRLLIAGCIASLIAYTVPQAMGSGMSAI-TIAVESPEDMQLL 305

Query: 302 FLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPA-----AITVSCAI 356
             + + KL A + A   G  GG I P + +GV +G ++      +              +
Sbjct: 306 TTILIAKLLATLFAIGLGIPGGLIGPVIGLGVLIGTLMAFFAQFISPGTDIAGTYGVLGM 365

Query: 357 LGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWL----LLAGKPMMMVNRPKQQ 412
            G++         +L     +  +  ++    IV+  A++    +   + + +     Q+
Sbjct: 366 AGLLAATLHAPLAALTTVMELTSSPEIIVPAMIVITTAYVTALQVFGNRSIFLQQLDFQE 425

Query: 413 PP 414
            P
Sbjct: 426 LP 427


>UniRef50_C4QGN7 Chloride channel protein, putative n=1 Tax=Schistosoma mansoni
           RepID=C4QGN7_SCHMA
          Length = 852

 Score =  181 bits (460), Expect = 4e-44,   Method: Composition-based stats.
 Identities = 63/511 (12%), Positives = 134/511 (26%), Gaps = 110/511 (21%)

Query: 13  SLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGI----------------AQDSP 56
               + +G+ +  I  ++    + + +L                            Q   
Sbjct: 170 WFCVLCVGLLTGFIACIIDIGCTWMSDLKEGVCLDAFWFNREQCCWSSSQADDVCDQWYS 229

Query: 57  L-----------------------WIIGVLTLTGIAVGLVIRFSQGHAGP-DPACEPLIG 92
                                   +II  +    + V LV  F+    G   P  + ++G
Sbjct: 230 WSRLFMNKDPTGEYPDAYFVGYLFYIIYAVLFALVCVFLVRMFAPYACGSGIPEIKTILG 289

Query: 93  A-----PVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARLL----PRVN 143
                  +    L    V +ILG+  G++LG E P++ +   +                 
Sbjct: 290 GFIIRGYLGKWTLLIKSVGMILGVGAGLNLGKEGPMVHMAACVGNIFAHFFPKYGQNEAK 349

Query: 144 RMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEV-PLWDRLFAPLMAAAAGALTTGL 202
           + E    ++A  +   FG P+   L   +  +    +  ++   F  +++A    +    
Sbjct: 350 KREILSASAAAGVAVAFGAPIGGVLFSLEEASYYFPMKTMFRSFFCAMVSANVLRILNPY 409

Query: 203 FFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLP---RLHAMMHQMKNPVL 259
                    + +  Q  + +++  A++  +    G V         RL       K PV 
Sbjct: 410 GSDNMIMFYVDYQAQWHVMELIPFALLGLLGGIFGTVFNRANLYICRLRKTTWLGKYPVR 469

Query: 260 VLGIGGFILGILGVIGGPVSLFKGLDEMQQMVA----NQAFST----------------- 298
            + +   I  IL             + ++ +V+       FS                  
Sbjct: 470 EVLVVTLITAIL-SFPHTYLRMNTSELIKLLVSRCSPGSDFSLCDYHFNTSNPMTKVYQN 528

Query: 299 -----------SDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHV---- 343
                          +  V+KL   V         G   P++  G  +G ML        
Sbjct: 529 YPAGPSLSTAMVLLAIALVLKLILTVFTFGIKVPTGLFIPSLAAGAIMGRMLGIATEQLV 588

Query: 344 -----------------PAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPL 386
                            P +   +         +  VTR     + +   +      +  
Sbjct: 589 VAYASHPFIVKMCKSSQPCINPGLYAMVGAAATLGGVTRMTISLVVVMLELTGGLNYIIP 648

Query: 387 LCIVMLPAWLLLAGK---PMMMVNRPKQQPP 414
           L I  + +           +   +      P
Sbjct: 649 LMIAAMVSKWTGDRLTNGSIYEEHIRLNDYP 679


>UniRef50_B9GHY7 Cl-channel clc-3 n=5 Tax=Magnoliophyta RepID=B9GHY7_POPTR
          Length = 568

 Score =  181 bits (460), Expect = 4e-44,   Method: Composition-based stats.
 Identities = 44/319 (13%), Positives = 96/319 (30%), Gaps = 24/319 (7%)

Query: 102 GLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARLLPRVNRM-EWTILASAGTIGALF 160
              +   + L  G SLGPE P + +  + A      +     RM       +A  I + F
Sbjct: 33  VKAIQAAVTLGTGCSLGPEGPSVDIGKSCAHGFSLMMANNRERMNTLIAAGAAAGISSGF 92

Query: 161 GTPVAAALIFSQTLNGSSEVPLWDRLFAPLM--AAAAGALTTGLFFHPHFSLPIAHYGQM 218
             PVA      +T+               ++  A+   +  +        +  +  Y   
Sbjct: 93  NAPVAGCFFAIETVLRPLHAENSPPFTTAMILLASVISSTVSNTLLGTQSAFTVPSYDLK 152

Query: 219 EMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGI----GGFILGILGVI 274
              ++    I+  +     +     +         +K    +  +     G +   +  +
Sbjct: 153 SAAELPLYLILGMLCGVVSVAFTRLVTWFTKSFEFIKEKFGLHPVACPALGGLGAGIIAL 212

Query: 275 GGPVSLFKGLDEMQQMVANQ----AFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVF 330
             P  L+ G   +++++       A        LA  K+ A  +   S   GG   P++ 
Sbjct: 213 KYPGILYWGFTNVEEILHTGKSASAPGIWLLTQLAAAKVVATALCKGSLLVGGLYAPSLM 272

Query: 331 VGVALGLMLHEHVPAV------------PAAITVSCAILGIVLVVTRDGWLSLFMAAVVV 378
           +G A+G +       +                     +   +  V      S+ +   + 
Sbjct: 273 IGAAVGAVFGGSAAELINSAIPGNAAVAQPQAYALVGMAATLASVCSVPLTSILLLFELT 332

Query: 379 PNTTLLPLLC-IVMLPAWL 396
            +  ++  L   V L  W+
Sbjct: 333 KDYRIILPLMGAVGLAIWV 351



 Score = 49.0 bits (116), Expect = 3e-04,   Method: Composition-based stats.
 Identities = 20/204 (9%), Positives = 53/204 (25%), Gaps = 34/204 (16%)

Query: 17  VAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRF 76
           + +G+   ++ +   ++ +               I +   L  +    L G+  G++   
Sbjct: 161 LILGMLCGVVSVAFTRLVTWFTK-------SFEFIKEKFGLHPVACPALGGLGAGIIALK 213

Query: 77  SQG----HAGPDPACEPLIGAPVPPSALPG------LIVALILGLAGGVSLGPEHPIMTV 126
             G                 +   P            +VA  L     +  G   P + +
Sbjct: 214 YPGILYWGFTNVEEILHTGKSASAPGIWLLTQLAAAKVVATALCKGSLLVGGLYAPSLMI 273

Query: 127 NIALAVAIGARL-----------LPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLN 175
             A+    G                      + ++  A T+ ++   P+ + L+  +   
Sbjct: 274 GAAVGAVFGGSAAELINSAIPGNAAVAQPQAYALVGMAATLASVCSVPLTSILLLFELTK 333

Query: 176 GSSEVPLWDRLFAPLMAAAAGALT 199
                  +  +   + A       
Sbjct: 334 ------DYRIILPLMGAVGLAIWV 351


>UniRef50_Q6C6J6 YALI0E09015p n=1 Tax=Yarrowia lipolytica RepID=Q6C6J6_YARLI
          Length = 772

 Score =  181 bits (459), Expect = 6e-44,   Method: Composition-based stats.
 Identities = 65/477 (13%), Positives = 136/477 (28%), Gaps = 75/477 (15%)

Query: 5   RARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDS--------- 55
           R        +  +  GIA  LI   +   +  + ++          +++DS         
Sbjct: 100 RLVNTSRRWIILIGTGIAVGLIAACIDITSHWIADVRLGYCQNAFYLSRDSCCSGIATND 159

Query: 56  --PLWI--------------IGVLTLTGIAVGLVIRFSQGHAGPDPACEP------LIGA 93
             P WI                 +     A  LVI +S        +         +I  
Sbjct: 160 PCPGWIEWSSSYFLRYMMYTFICVICATSASVLVITYSPHSKLSGISEIKTILAGYIIKG 219

Query: 94  PVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGA---RLLPRVNRMEWTIL 150
            +    L    + L L +  GV +G E P++ V    A  +     R      + E    
Sbjct: 220 FMGKWTLLIKSLGLGLAVGSGVWVGKEGPLVHVACCCANLLIRYTSREHNEAQKREILSA 279

Query: 151 ASAGTIGALFGTPVAAALIFSQTLNGSSE-VPLWDRLFAPLMAAAAGALTTGLFFHPHFS 209
           A+A  I   FG+P+   L   + ++       +W      ++AA                
Sbjct: 280 AAAAGISVAFGSPIGGVLFSLEQVSYYFPDKTMWHSFVCAMIAAVTLQFVNPFRTGKLVL 339

Query: 210 LPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWC---LPRLHAMMHQMKNPVLVLGIGGF 266
             + +       +++  AI+       G   +       ++         P+L + I   
Sbjct: 340 FQVEYDRLWHRFELVPFAILGIFGGLYGAYFIKLNLKYAKMRKTTFIKNFPILEVAILAL 399

Query: 267 ILGILG-----VIGGPVSLFK------GLDEMQQMVANQAFSTSDYFLLAVIKLAALVVA 315
           I G++      +   P  L             + +     +S S   LL+   L  L+ +
Sbjct: 400 ITGLINYPNVYMRLQPSVLLSYLFQECNASTPEALCNLDNWSQSVALLLSACGLGFLLAS 459

Query: 316 AASGF--RGGRIFPAVFVGVALGLMLHEHVPAVP--------------------AAITVS 353
            + G     G I P++ +G   G  +   +                          +   
Sbjct: 460 YSFGVALPAGIIIPSMCIGALFGRAVGILMATWHETNRDFFLFASCPAEGTCVTPGVYAV 519

Query: 354 CAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPA-WL---LLAGKPMMMV 406
                 +  VTR     + +   +      +  +   ++ + W+   +   + +   
Sbjct: 520 VGAASALGGVTRLTISIVVITFELTGALNYVLPIMAGVMVSKWVGDAIGGKRGIYES 576


>UniRef50_C7HUJ8 Chloride channel protein n=1 Tax=Anaerococcus vaginalis ATCC 51170
           RepID=C7HUJ8_9FIRM
          Length = 432

 Score =  180 bits (458), Expect = 8e-44,   Method: Composition-based stats.
 Identities = 53/388 (13%), Positives = 128/388 (32%), Gaps = 15/388 (3%)

Query: 22  ASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRFSQGHA 81
            + L++ +   +   +  ++   +        ++ +++   + +  +    V +      
Sbjct: 28  CAGLVVSLFRLLIPKVMFVISNLIIFGQKNLLNAIIFVFTFIFIGFLVSICVNKEPMIGG 87

Query: 82  GPDPACEPLIGAPVPPSAL---PGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARL 138
              P     +   +  SAL      I+  +L +  G++LG E P + +  +L   +    
Sbjct: 88  SGIPQISGKLHDKLDYSALSCLINKIIGGLLAIGSGLTLGREGPSVQIGGSLGEVMANIF 147

Query: 139 LPRVNRMEWTILASAG-TIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGA 197
               +  +  I+ S+   I + F  P++A     + L                    + +
Sbjct: 148 KLDDDDKKIMIIGSSASGITSAFTAPISAIAFALEELMKK---TSRINFIYITSTIISSS 204

Query: 198 LTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNP 257
           + T L       + I ++  + M   +    +  +   + ++    +     +   +   
Sbjct: 205 IVTSLIIGNDPVIKIKNHLNLSMRFWIYLIFLGILVGFSSILFNKSILSGKKLYKNLPIS 264

Query: 258 VLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAA 317
             +  I  F +  + ++     L  G + +  +     +  S       +KL  L++A  
Sbjct: 265 QSIKSIIPFFITSIFLLFDSRLLGSGENFI-SLAQGDNYEISTLIYFYFMKLLLLLIAFC 323

Query: 318 SGFRGGRIFPAVFVGVALGLMLH------EHVPAVPAAITVSCAILGIVLVVTRDGWLSL 371
           SG  GG  FP + +G  +G            V      I    A+      + R     +
Sbjct: 324 SGIPGGIFFPLLAMGSLIGNFYGCILFELNLVGENEIIIFSMLAMAAHFASIVRAPLTGM 383

Query: 372 FMAAVVVPN-TTLLPLLCIVMLPAWLLL 398
           F+   +          + IV L A+LL 
Sbjct: 384 FLIIEMTGGRIDFFLPIIIVSLVAYLLT 411


>UniRef50_A5VU61 Voltage gated chloride channel family protein n=40 Tax=Rhizobiales
           RepID=A5VU61_BRUO2
          Length = 490

 Score =  180 bits (457), Expect = 9e-44,   Method: Composition-based stats.
 Identities = 64/413 (15%), Positives = 129/413 (31%), Gaps = 33/413 (7%)

Query: 6   ARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTL 65
            +  L+    A+AIGI S    +   + A + Q+            +       + +  L
Sbjct: 63  WKPRLVFWCGALAIGIIS----VGFAEAADIAQDWF----HSLTSGSPLRAWLPLLITPL 114

Query: 66  TGIAVGLV--IRFSQGHAGPDPACEPLIGAP--------VPPSALPGLIVALILGLAGGV 115
             +    V  + F        P                 +      G IV  I+GL  G 
Sbjct: 115 GFMFCSWVALVWFPNSGGSGIPQAIAARHLNDHEDRSLLLSIRVATGKIVLTIIGLFCGA 174

Query: 116 SLGPEHPIMTVNIALAVAIGARLLPRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLN 175
           S+G E P + +  ++     AR           +  SA  I A F TP+A  +   + + 
Sbjct: 175 SIGREGPTVQIGASIM-LQAARFGGMEKARGLILAGSAAGIAAAFNTPLAGIVFAIEEMG 233

Query: 176 GSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIA 235
            +        + + ++ A   +L        +              D +          A
Sbjct: 234 RAYAARTNGLVLSAVILAGLASL---GLVGNYNYFGFTTVTASTGKDWILTIACGIFGGA 290

Query: 236 AGMVAVWCLPRLHAMMHQ------MKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQ 289
            G         +   + +      ++N V+  GI G ++ ++G+  G ++   G D+ + 
Sbjct: 291 FGAAFSALALNMGRRVRRRVQKAPLRNMVIFAGICGLLVALIGIASGGMTFGAGYDQARS 350

Query: 290 MVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAA 349
            V              V K    +++  SG  GG   P++ VG  LG  +   +    A+
Sbjct: 351 AVEGATLPP----FYFVEKFTVGLLSMISGIPGGIFAPSLSVGAGLGSTIGLLL-GTSAS 405

Query: 350 ITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKP 402
           +     + G      +    +  +   +  N + +  L    +  +       
Sbjct: 406 LAAVLGMAGYFAGAVQAPMTAFVIILEMTGNHSNVIPLMCASMLGYGTARLIS 458


>UniRef50_B1Z0X2 Chloride channel core n=79 Tax=Bacteria RepID=B1Z0X2_BURA4
          Length = 468

 Score =  179 bits (456), Expect = 1e-43,   Method: Composition-based stats.
 Identities = 65/375 (17%), Positives = 122/375 (32%), Gaps = 16/375 (4%)

Query: 41  LWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGLVIRFSQGHAGP----DPACEPLIGAPVP 96
           L+          + +  W++  L   G A G V                       A VP
Sbjct: 91  LFLLALDWATGTRVAHPWLLWGLPAAGFATGWVYHRFGQSVARGNNLLIDEIHDPKALVP 150

Query: 97  PSALPGLIVALILGLAGGVSLGPEHPIMTVNIALAVAIGARLLP-RVNRMEWTILASAGT 155
               P ++VA ++    G S G E   + +  ALA  +       R +R    +   A  
Sbjct: 151 KRMAPLVLVATVVTHLFGGSAGREGTAVQMGGALADRVTHLFRLDREHRRVLLMGGIAAG 210

Query: 156 IGALFGTPVAAALIFSQTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHY 215
             ++FGTP+A A+   + L  +     +D L   + +A    +    +   H    I   
Sbjct: 211 FSSVFGTPLAGAVFGLEVL--AIGRVRYDALLTCVASAIVADVVCRAWGVHHTVYAIPFV 268

Query: 216 GQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIG 275
             +  T + +  +        G +  +    L     ++     +  + G  +  +    
Sbjct: 269 PAVSATGLAATVVAGVAFGVVGRLFAFATHALTGWFRRVVRHAPLQPVLGGAIVAVAATV 328

Query: 276 G--PVSLFKGLDEMQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGV 333
              P  L  G+  ++        +          K A  VV  ASGF+GG + P  ++G 
Sbjct: 329 LNVPQYLGLGIPTIEAAFHGPLPAYD-----FAGKFAFTVVTLASGFKGGEVTPLFYIGA 383

Query: 334 ALGLMLHEHVPAVPAAITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLP 393
            LG  L + + A+P  +      + +          S  MA  +     +     +  + 
Sbjct: 384 TLGNALGQVL-ALPVPVLAGLGFVAVFAGAANTPIASTIMAIELFG-ADVGVYAIVACVV 441

Query: 394 AWLLLAGKPMMMVNR 408
           A+L      +    R
Sbjct: 442 AYLFSGHAGIYRAQR 456


>UniRef50_A3ZQR8 Chloride channel protein-like n=1 Tax=Blastopirellula marina DSM
           3645 RepID=A3ZQR8_9PLAN
          Length = 655

 Score =  179 bits (456), Expect = 1e-43,   Method: Composition-based stats.
 Identities = 58/459 (12%), Positives = 124/459 (27%), Gaps = 73/459 (15%)

Query: 13  SLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTGIAVGL 72
            + A   G+ +    ++   +  +++ L   R            + +     L  + V  
Sbjct: 32  IVLAAIAGVLTGYGSVLFAYLFEIIRELTVLRFVAWSEFTIWGYVALAASPALGILFVAW 91

Query: 73  VIRFSQGHAGPDPACE---PLIGAPVPPSALPGLIVALILGLAGGVSLGPEHPIMTVNIA 129
             R+ +      P            + P      + +  + +  G S+GPE P++ +  +
Sbjct: 92  FTRYFRLEGQAVPEVIKSVARKDGVIRPFWSLAKVFSSAVCIGVGGSVGPEGPMVLIGSS 151

Query: 130 LAVAIGARLL-PRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVPLWDRLFA 188
           +A A G        N        +A  I A F  P+A  +   + + GS  V     +  
Sbjct: 152 IASAAGQFFRLSSRNLRTLVAAGAAAGISAAFNAPIAGVIFSCEIILGSFAVESLTPIVI 211

Query: 189 PLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAVWCLPRLH 248
             + AA      G          I+H       ++ S  ++  I   A +  V  L    
Sbjct: 212 AAVLAAVVQKQVGEHGVNVAFPQISHEYAGNWVELPSYFLLGIICGFASIAFVRLLYWTE 271

Query: 249 AMMH-QMKNPVLVLGIGGFILGILGVIGG------------------------------- 276
            +         +     G ++G+LG                                   
Sbjct: 272 DVAKAWTPKWWIRALACGTLVGVLGAGYFVVYPAPPTISAEESANESDSLAEEMSQEGHH 331

Query: 277 ---PVSLFKGLDEMQQMVANQA----------------------------FSTSDYFLLA 305
              P     G D ++  +  Q                                     L 
Sbjct: 332 PRGPALYGVGYDTVEHSLHLQNADKPMPVRRQNVDIASTKVVPLSREEMIAHLWWLVPLI 391

Query: 306 VIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAV------PAAITVSCAILGI 359
           ++K     +    G  GG   P++F+G  LG         +               +  +
Sbjct: 392 LLKPICTSLTLGGGGAGGIFAPSLFLGATLGGAYGIVCNLIAPDMCASPGAYALVGMGAV 451

Query: 360 VLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL 398
           V   T     ++ +   +  +  ++  +      + ++ 
Sbjct: 452 VAGTTHGVLSAILIVYELTGDYHIILPIMGAACISSVVA 490


>UniRef50_Q0AMZ1 Cl-channel, voltage-gated family protein n=2 Tax=Hyphomonadaceae
           RepID=Q0AMZ1_MARMM
          Length = 565

 Score =  179 bits (455), Expect = 2e-43,   Method: Composition-based stats.
 Identities = 66/410 (16%), Positives = 134/410 (32%), Gaps = 27/410 (6%)

Query: 12  LSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQ--DSPLWIIGVLTLTGIA 69
           L   A+ +GI +    + +      ++   +      L  A        I+ +  +TG  
Sbjct: 47  LWGLAILVGICAGYATLGLRLGIGFVEQFAFGATEEQLASAASDLPAWRIVIIPLVTGCI 106

Query: 70  VGLVIRFSQGHAGP----------DPACEPLIGAPVPPSALPGLIVALILGLAGGVSLGP 119
           + +++   +                     +    +   A     V   + L GG S G 
Sbjct: 107 IAVMLGLGRRFGLSPDGRGLGVADVLEARAVKSGRIDLKAGLYSAVMSAISLGGGASAGR 166

Query: 120 EHPIMTVNIALAVAIGARLLPRVN-RMEWTILASAGTIGALFGTPVAAALIFSQTLNGSS 178
           E P + +   LA   G+RL              +A  + A F  PVA AL   + + G  
Sbjct: 167 EGPAVHLGATLAAFFGSRLGMAARGSRILLACGAAAAVSASFNAPVAGALFAFEIVLGHY 226

Query: 179 EVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGM 238
            +     +     ++  GAL     F       +       + D  + A++   A    +
Sbjct: 227 AL---RSIAPVATSSVVGALIVRHHFGQAPVFGVPEMAAASLWDFPAAALLGVAAAGLVI 283

Query: 239 VAVWCLPRLHAMM----HQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQ 294
           +    +  L  +      ++  P  +L I G +   L  +  P  L  G +     + +Q
Sbjct: 284 IFNRGVIHLPPLFASWTDKLNLPNWLLPIPGGLAVGLIALMAPEILGVGYEATSNALTSQ 343

Query: 295 AFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVP------A 348
            ++ S   LL V+K  A ++  A  F GG   P++++G  LG      +  +        
Sbjct: 344 -YTFSLVVLLLVLKTVATIITLACRFPGGVFSPSLYLGAMLGSAFGLSLAVLAGDQTAGP 402

Query: 349 AITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL 398
                  +  +   V      +  +   +  +      + + +  A +L 
Sbjct: 403 GFFAVIGMGAVAGAVLGAPLSTTLIVFELTASYEASVAVLVAVSLATVLS 452


>UniRef50_A6C318 Chloride channel protein n=2 Tax=Bacteria RepID=A6C318_9PLAN
          Length = 453

 Score =  179 bits (454), Expect = 2e-43,   Method: Composition-based stats.
 Identities = 59/420 (14%), Positives = 138/420 (32%), Gaps = 23/420 (5%)

Query: 7   RTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPL-WIIGVLTL 65
           +T + + L A+ IG+    +          + ++         G A  + L   I    +
Sbjct: 13  KTAMWIYLLALVIGVGVGTLGSAFHYCLDKVIDVYAVISTSFSGSAFLTILTAAIIGAAM 72

Query: 66  TGIAVGLVIRFSQGHAGP-DPACEPLIGAPVPPS---ALPGLIVALILGLAGGVSLGPEH 121
              A  LV +++   AG      E ++G  +       LP   +  +L +  G+ LG E 
Sbjct: 73  VATAAVLVRKYAPETAGSGIQEVEGVMGELMTLRWRSVLPVKFIGGVLSMGAGLVLGREG 132

Query: 122 PIMTVNIALAVAIGARLLPRVNRM-EWTILASAGTIGALFGTPVAAALIFSQTLNGSSEV 180
           P + +   +   +G +     + +  +    +   +   F  P+ A L   + +    + 
Sbjct: 133 PTIHLGGCVGQIVGEKANSDKHTLNTFLAAGATAGLSVAFSAPLGAILFMIEEVRPRFQY 192

Query: 181 PLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDIL--------SGAIVAAI 232
                L A ++A+    L     F     LP+     +                 ++ A+
Sbjct: 193 SFV-ALHAVIIASITANLVNDQVFGTLPQLPVQLQASLPTFQPPGNLLLTLSLNLLLGAL 251

Query: 233 AIAAGMVAVWCLPRLHAMMHQMKNPVLVLGIGG-FILGILGVIGGPVSLFKGLDEMQQMV 291
               G      + +   +   + + ++++       +    +I  P  +  G   ++++ 
Sbjct: 252 IGVLGAGFNSVMLKCLRISDGLNSRLMLVIAASVGAVVGALMIIAPEYVGGGEALVKEIF 311

Query: 292 ANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPA--- 348
           A           L V++     ++ + G  GG   P + +G  +G      V  +     
Sbjct: 312 AESPLLGFL-LALLVVRAGLTFLSYSMGVPGGIFAPMLALGALIGTSFGYVVHELAPQAE 370

Query: 349 ---AITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAGKPMMM 405
              A     A+  +     R     + + A +  +  LLP + +  + A ++        
Sbjct: 371 LQAATFAVAAMGALFAATVRAPLTGIVLVAEMTDSFELLPAMIVTCMTASIVAQSLGSRP 430


>UniRef50_C4LLM1 Putative ion channel protein n=1 Tax=Corynebacterium kroppenstedtii
           DSM 44385 RepID=C4LLM1_CORK4
          Length = 442

 Score =  179 bits (454), Expect = 2e-43,   Method: Composition-based stats.
 Identities = 63/403 (15%), Positives = 131/403 (32%), Gaps = 16/403 (3%)

Query: 8   TMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQRLPGTLGIAQDSPLWIIGVLTLTG 67
           +M+ L++ AV +G+ + +I  +        +         +        +  I    +  
Sbjct: 2   SMVPLTITAVMVGLGTGIIASLFRVCLEHAEAWRTTVFEWSQDHGVIGVIVAIVAPAVLA 61

Query: 68  IAVGLVIRFSQ--GHAGPDPACEPLIGAPVPP---SALPGLIVALILGLAGGVSLGPEHP 122
           +    ++R  +        P  E ++     P     LP   +  ++ + GG++LG E P
Sbjct: 62  MVGAAMVRHLEPVAEGSGIPRVEAIVKGNANPTHMRLLPIKFIGGLMSIGGGLALGREGP 121

Query: 123 IMTVNIALAVAIGARLL-PRVNRMEWTILASAGTIGALFGTPVAAALIFSQTLNGSSEVP 181
            + +  ++A  +G      R +        +A  +   F  P+A A+   + L    E  
Sbjct: 122 SVHLGASVATILGRTYRNNRADLRLLIAAGAASGLTTAFSAPLAGAVFVLEELVKRFEA- 180

Query: 182 LWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQMEMTDILSGAIVAAIAIAAGMVAV 241
                 A L A+ A      +        P+       + +     IV  +A  AG++  
Sbjct: 181 --RMTVAVLSASGAAYSMAHIIVGDDHVFPLPEPAPPTLDNGPFFLIVGLVAGFAGLLYN 238

Query: 242 WCLPRLHAMMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDEMQQMVANQAFSTSDY 301
             L R  A++     PV +          +    GP  +  G       +  +  +    
Sbjct: 239 RTLMRTLAVVDASTFPVELRAGMIGAAIGIVGYLGPNLVGGGDSLTMDALMGRG-TVMVL 297

Query: 302 FLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAVPAAIT------VSCA 355
             L V++    + +  +   GG   P + +G  LGL++     A+   +           
Sbjct: 298 LGLLVLRFIMAIGSYVALTPGGLFAPMLVLGAELGLIVGLVCHALFPQVAPDPSAMAIVG 357

Query: 356 ILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLL 398
           +  +           L +   +     LLP L      A  + 
Sbjct: 358 MAALFAASVGAPVTGLVLTTEMTGAVVLLPPLLGACAVAMFIA 400


>UniRef50_Q1GIU0 Cl-channel voltage gated n=37 Tax=Rhodobacterales
           RepID=Q1GIU0_SILST
          Length = 564

 Score =  179 bits (454), Expect = 2e-43,   Method: Composition-based stats.
 Identities = 62/435 (14%), Positives = 137/435 (31%), Gaps = 27/435 (6%)

Query: 1   MLHPRARTMLLLSLPAVAIGIASSLILIVVMKIASVLQNLLWQR---LPGTLGIAQDSPL 57
           +L  R  + L   L A+ IG+ +    +   K  + LQ  ++            A     
Sbjct: 26  VLVHRGPSQLQFWLIALVIGVLAGFAALFFRKGITALQGAVYGAEDVDYLHSFAATLPWY 85

Query: 58  WIIGVLTLTGIAVGLVIRFSQGHA-----GPDPACEPLIGAPVPPSALPGLIVALILGLA 112
            ++ V    G+ VG+++                    L    V          A  L L+
Sbjct: 86  VLLLVPVFGGLIVGIILHRFTPDGRVRSVADVIEGAALRDGRVEIREGLASACASFLTLS 145

Query: 113 GGVSLGPEHPIMTVNIALAVAIGARLLPRV-NRMEWTILASAGTIGALFGTPVAAALIFS 171
            G S G E P++ +   ++  +  R+        +    A A  + A F  P+A AL   
Sbjct: 146 TGGSSGREGPVVHIAGMISTWVSDRIRADGITGRDLLGCAVAAAVSASFNAPIAGALFAM 205

Query: 172 QTLNGSSEVPLWDRLFAPLMAAAAGALTTGLFFHPHFSLPIAHYGQME-MTDILSGAIVA 230
           + +     V         ++A+ AG +   L +       +   G ++   ++ +  ++ 
Sbjct: 206 EVVLRHFSVN---TFAPIVVASVAGTVINRLEYGDVTEFVLTTPGALQFYVELPAFLMLG 262

Query: 231 AIAIAAGMVAVWCLPRLHA----MMHQMKNPVLVLGIGGFILGILGVIGGPVSLFKGLDE 286
            I     +V +  +         +   +  P  +       L  L  I  P  +  G + 
Sbjct: 263 LICGVVAVVLMHSIFLADRVGTAVQSALGMPRWLRPTVAGFLLGLVAIWYPHIIGVGYET 322

Query: 287 MQQMVANQAFSTSDYFLLAVIKLAALVVAAASGFRGGRIFPAVFVGVALGLMLHEHVPAV 346
               ++     +    L  ++K+AA+ +       GG   P++ VG   GL         
Sbjct: 323 TVLALSGSLLLSQ-AILFTIVKVAAVSITMGGRMGGGVFSPSLMVGALTGLAFGLIATNF 381

Query: 347 PA------AITVSCAILGIVLVVTRDGWLSLFMAAVVVPNTTLLPLLCIVMLPAWLLLAG 400
                    +     +  +   V      +  +   +  +  +   + + +  +  L + 
Sbjct: 382 LPDVSGTHTLYAFAGMGAVAAAVLGAPISTTLIVFELTGDWQIGLAVMVSVSMSTALASR 441

Query: 401 ---KPMMMVNRPKQQ 412
              +   +    K+ 
Sbjct: 442 MVDRSFFLTQLEKRD 456


  Database: uniref50.fasta
    Posted date:  Mar 8, 2010 10:38 AM
  Number of letters in database: 1,040,396,356
  Number of sequences in database:  3,077,464
  
Lambda     K      H
   0.317    0.161    0.413 

Lambda     K      H
   0.267   0.0493    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 2,200,429,006
Number of Sequences: 3077464
Number of extensions: 93097313
Number of successful extensions: 961993
Number of sequences better than 1.0e-01: 250
Number of HSP's better than  0.1 without gapping: 1128
Number of HSP's successfully gapped in prelim test: 18018
Number of HSP's that attempted gapping in prelim test: 900675
Number of HSP's gapped (non-prelim): 58211
length of query: 418
length of database: 1,040,396,356
effective HSP length: 131
effective length of query: 287
effective length of database: 637,248,572
effective search space: 182890340164
effective search space used: 182890340164
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (20.9 bits)
S2: 95 (40.9 bits)
