Phyre 2 Results for P76123

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Email | l.a.kelley@imperial.ac.uk
Description | P76123
Date | Thu Jan 5 12:19:16 GMT 2012
Unique Job ID | 9bcdf97e57716955

Summary |

Top model
Image coloured by rainbow N → C terminus
| Close Jmol

Model (left) based on template c2ft3B_
Top template information
PDB header:structural protein, signaling protein Chain: B: PDB Molecule:biglycan; PDBTitle: crystal structure of the biglycan dimer core protein
Confidence and coverage
Confidence: | 100.0% | Coverage: | 89%
284 residues ( 89% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
3D viewing
Interactive 3D view in Jmol

Sequence analysis |

Secondary structure and disorder prediction |

|  | 1 | . | . | . | . | . | . | . | . | 10 | . | . | . | . | . | . | . | . | . | 20 | . | . | . | . | . | . | . | . | . | 30 | . | . | . | . | . | . | . | . | . | 40 | . | . | . | . | . | . | . | . | . | 50 | . | . | . | . | . | . | . | . | . | 60
Sequence |  | M | I | T | D | L | I | L | H | N | H | P | R | M | K | T | I | T | L | N | D | N | H | I | A | H | L | N | A | K | N | T | T | K | L | E | Y | L | N | L | S | N | N | N | L | L | P | T | N | D | I | D | Q | L | I | S | S | K | H | L | W
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  | ? | ? | ? | ? | ? |  | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? |  |  |  | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? | ? | ? | ? | ? |  |  |  |  | ?
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 70 | . | . | . | . | . | . | . | . | . | 80 | . | . | . | . | . | . | . | . | . | 90 | . | . | . | . | . | . | . | . | . | 100 | . | . | . | . | . | . | . | . | . | 110 | . | . | . | . | . | . | . | . | . | 120
Sequence |  | H | V | L | V | N | G | I | N | N | D | P | L | A | Q | M | Q | Y | W | T | A | V | R | N | I | I | D | D | T | N | E | V | T | I | D | L | S | G | L | N | L | T | T | Q | P | P | G | L | Q | N | F | T | S | I | N | L | D | N | N | Q | F
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  | ? |  | ? | ? |  | ? | ? | ? | ? | ? | ? | ? |  |  |  | ? |  | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 130 | . | . | . | . | . | . | . | . | . | 140 | . | . | . | . | . | . | . | . | . | 150 | . | . | . | . | . | . | . | . | . | 160 | . | . | . | . | . | . | . | . | . | 170 | . | . | . | . | . | . | . | . | . | 180
Sequence |  | T | H | F | D | A | T | N | Y | D | R | L | V | K | L | S | L | N | S | N | A | L | E | S | I | N | F | P | Q | G | R | N | V | S | I | T | H | I | S | M | N | N | N | A | L | R | N | I | D | I | D | R | L | S | S | V | T | Y | F | S | A
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  | ? |  |  |  | ? |  |  |  |  | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 190 | . | . | . | . | . | . | . | . | . | 200 | . | . | . | . | . | . | . | . | . | 210 | . | . | . | . | . | . | . | . | . | 220 | . | . | . | . | . | . | . | . | . | 230 | . | . | . | . | . | . | . | . | . | 240
Sequence |  | A | H | N | Q | L | E | F | V | Q | L | E | S | C | E | W | L | Q | Y | L | N | L | S | H | N | Q | L | T | D | I | V | A | G | N | K | N | E | L | L | L | L | D | L | S | H | N | K | L | T | S | L | H | N | D | L | F | P | N | L | N | T
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  | ? |  |  | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? |  | ? |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 250 | . | . | . | . | . | . | . | . | . | 260 | . | . | . | . | . | . | . | . | . | 270 | . | . | . | . | . | . | . | . | . | 280 | . | . | . | . | . | . | . | . | . | 290 | . | . | . | . | . | . | . | . | . | 300
Sequence |  | L | L | I | N | N | N | L | L | S | E | I | K | I | F | Y | S | N | F | C | N | V | Q | T | L | N | A | A | N | N | Q | L | K | Y | I | N | L | D | F | L | T | Y | L | P | S | I | K | S | L | R | L | D | N | N | K | I | T | H | I | D | T
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? |  |  | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  | ? |  |  | ? |  | ?
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 310 | . | . | . | . | . | . | . | .
Sequence |  | N | N | T | S | D | I | G | T | L | F | P | I | I | K | Q | S | K | T
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  | ? | ? | ? | ? | ? |  |  |  |  |  |  |  | ? | ? | ? | ? | ? | ?
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

Confidence Key
High(9) |  |  |  |  |  |  |  |  |  |  | Low (0)

? | Disordered
| Alpha helix
| Beta strand

Domain analysis |

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank | Aligned region
--- | ---
1 |
| c2ft3B_ |

### PDB 2ft3 chain B

Region: 8 - 309
Aligned: 284
Modelled: 284
Confidence: 100.0%
Identity: 13%
PDB header:structural protein, signaling protein
Chain: B: PDB Molecule:biglycan;
PDBTitle: crystal structure of the biglycan dimer core protein

Phyre2
2 |
| c3ojaB_ |

### PDB 3oja chain B

Region: 2 - 310
Aligned: 282
Modelled: 283
Confidence: 100.0%
Identity: 15%
PDB header:protein binding
Chain: B: PDB Molecule:anopheles plasmodium-responsive leucine-rich repeat protein
PDBTitle: crystal structure of lrim1/apl1c complex

Phyre2
3 |
| d2omza2 |

### PDB 2omz chain A domain 2

Region: 1 - 309
Aligned: 303
Modelled: 309
Confidence: 100.0%
Identity: 14%
Fold: Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)
Superfamily: L domain-like
Family: Internalin LRR domain

Phyre2
4 |
| c1xkuA_ |

### PDB 1xku chain A

Region: 12 - 309
Aligned: 281
Modelled: 281
Confidence: 100.0%
Identity: 15%
PDB header:structural protein
Chain: A: PDB Molecule:decorin;
PDBTitle: crystal structure of the dimeric protein core of decorin, the2 archetypal small leucine-rich repeat proteoglycan

Phyre2
5 |
| d1xkua_ |

### PDB 1xku chain A

Region: 12 - 309
Aligned: 281
Modelled: 281
Confidence: 100.0%
Identity: 15%
Fold: Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)
Superfamily: L domain-like
Family: Ngr ectodomain-like

Phyre2
6 |
| c2id5D_ |

### PDB 2id5 chain D

Region: 2 - 309
Aligned: 272
Modelled: 272
Confidence: 100.0%
Identity: 13%
PDB header:ligand binding protein,membrane protein
Chain: D: PDB Molecule:leucine rich repeat neuronal 6a;
PDBTitle: crystal structure of the lingo-1 ectodomain

Phyre2
7 |
| c2z63A_ |

### PDB 2z63 chain A

Region: 2 - 309
Aligned: 308
Modelled: 308
Confidence: 100.0%
Identity: 14%
PDB header:immune system
Chain: A: PDB Molecule:toll-like receptor 4, variable lymphocyte receptor b;
PDBTitle: crystal structure of the tv8 hybrid of human tlr4 and hagfish vlrb.61

Phyre2
8 |
| c2omwA_ |

### PDB 2omw chain A

Region: 7 - 307
Aligned: 297
Modelled: 301
Confidence: 100.0%
Identity: 15%
PDB header:cell invasion/cell adhesion
Chain: A: PDB Molecule:internalin-a;
PDBTitle: crystal structure of inla s192n y369s/mec1 complex

Phyre2
9 |
| c2z64A_ |

### PDB 2z64 chain A

Region: 2 - 309
Aligned: 308
Modelled: 308
Confidence: 100.0%
Identity: 16%
PDB header:immune system
Chain: A: PDB Molecule:toll-like receptor 4;
PDBTitle: crystal structure of mouse tlr4 and mouse md-2 complex

Phyre2
10 |
| c3o6nA_ |

### PDB 3o6n chain A

Region: 7 - 310
Aligned: 301
Modelled: 304
Confidence: 100.0%
Identity: 15%
PDB header:protein binding
Chain: A: PDB Molecule:apl1;
PDBTitle: crystal structure of apl1 leucine-rich repeat domain

Phyre2
11 |
| c3fxiA_ |

### PDB 3fxi chain A

Region: 2 - 309
Aligned: 308
Modelled: 308
Confidence: 99.9%
Identity: 15%
PDB header:immune system
Chain: A: PDB Molecule:toll-like receptor 4;
PDBTitle: crystal structure of the human tlr4-human md-2-e.coli lps ra complex

Phyre2
12 |
| c1ziwA_ |

### PDB 1ziw chain A

Region: 2 - 309
Aligned: 308
Modelled: 308
Confidence: 99.9%
Identity: 17%
PDB header:immune system
Chain: A: PDB Molecule:toll-like receptor 3;
PDBTitle: human toll-like receptor 3 extracellular domain structure

Phyre2
13 |
| c3rg1I_ |

### PDB 3rg1 chain I

Region: 2 - 309
Aligned: 305
Modelled: 308
Confidence: 99.9%
Identity: 11%
PDB header:immune system
Chain: I: PDB Molecule:cd180 molecule;
PDBTitle: crystal structure of the rp105/md-1 complex

Phyre2
14 |
| c3a79A_ |

### PDB 3a79 chain A

Region: 2 - 309
Aligned: 303
Modelled: 306
Confidence: 99.9%
Identity: 16%
PDB header:immune system
Chain: A: PDB Molecule:toll-like receptor 2, variable lymphocyte receptor b;
PDBTitle: crystal structure of tlr2-tlr6-pam2csk4 complex

Phyre2
15 |
| c2a0zA_ |

### PDB 2a0z chain A

Region: 2 - 309
Aligned: 308
Modelled: 308
Confidence: 99.9%
Identity: 18%
PDB header:immune system
Chain: A: PDB Molecule:toll-like receptor 3;
PDBTitle: the molecular structure of toll-like receptor 3 ligand binding domain

Phyre2
16 |
| c2z7xB_ |

### PDB 2z7x chain B

Region: 2 - 296
Aligned: 293
Modelled: 295
Confidence: 99.9%
Identity: 18%
PDB header:immune system
Chain: B: PDB Molecule:toll-like receptor 1, variable lymphocyte receptor b;
PDBTitle: crystal structure of the tlr1-tlr2 heterodimer induced by binding of a2 tri-acylated lipopeptide

Phyre2
17 |
| c3a79B_ |

### PDB 3a79 chain B

Region: 2 - 309
Aligned: 307
Modelled: 308
Confidence: 99.9%
Identity: 15%
PDB header:immune system
Chain: B: PDB Molecule:toll-like receptor 6, variable lymphocyte receptor b;
PDBTitle: crystal structure of tlr2-tlr6-pam2csk4 complex

Phyre2
18 |
| c3rgxA_ |

### PDB 3rgx chain A

Region: 2 - 309
Aligned: 307
Modelled: 308
Confidence: 99.9%
Identity: 21%
PDB header:transferase
Chain: A: PDB Molecule:protein brassinosteroid insensitive 1;
PDBTitle: structural insight into brassinosteroid perception by bri1

Phyre2
19 |
| c2z81A_ |

### PDB 2z81 chain A

Region: 2 - 309
Aligned: 303
Modelled: 301
Confidence: 99.9%
Identity: 16%
PDB header:immune system
Chain: A: PDB Molecule:toll-like receptor 2, variable lymphocyte receptor b;
PDBTitle: crystal structure of the tlr1-tlr2 heterodimer induced by binding of a2 tri-acylated lipopeptide

Phyre2
20 |
| c2z80A_ |

### PDB 2z80 chain A

Region: 9 - 296
Aligned: 279
Modelled: 288
Confidence: 99.9%
Identity: 15%
PDB header:immune system
Chain: A: PDB Molecule:toll-like receptor 2, variable lymphocyte receptor b;
PDBTitle: crystal structure of the tlr1-tlr2 heterodimer induced by binding of a2 tri-acylated lipopeptide

Phyre2
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28 |
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31 |
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33 |
34 |
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81 |
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83 |
84 |

Detailed template information |

# | Template | Alignment Coverage | 3D Model | Confidence | % i.d. | Template Information
--- | --- | --- | --- | --- | --- | ---
1 | c2ft3B_ |
|  | 100.0 | 13 | PDB header:structural protein, signaling protein Chain: B: PDB Molecule:biglycan; PDBTitle: crystal structure of the biglycan dimer core protein
2 | c3ojaB_ |
|  | 100.0 | 15 | PDB header:protein binding Chain: B: PDB Molecule:anopheles plasmodium-responsive leucine-rich repeat protein PDBTitle: crystal structure of lrim1/apl1c complex
3 | d2omza2 |
|  | 100.0 | 14 | Fold:Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) Superfamily:L domain-like Family:Internalin LRR domain
4 | c1xkuA_ |
|  | 100.0 | 15 | PDB header:structural protein Chain: A: PDB Molecule:decorin; PDBTitle: crystal structure of the dimeric protein core of decorin, the2 archetypal small leucine-rich repeat proteoglycan
5 | d1xkua_ |
|  | 100.0 | 15 | Fold:Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) Superfamily:L domain-like Family:Ngr ectodomain-like
6 | c2id5D_ |
|  | 100.0 | 13 | PDB header:ligand binding protein,membrane protein Chain: D: PDB Molecule:leucine rich repeat neuronal 6a; PDBTitle: crystal structure of the lingo-1 ectodomain
7 | c2z63A_ |
|  | 100.0 | 14 | PDB header:immune system Chain: A: PDB Molecule:toll-like receptor 4, variable lymphocyte receptor b; PDBTitle: crystal structure of the tv8 hybrid of human tlr4 and hagfish vlrb.61
8 | c2omwA_ |
|  | 100.0 | 15 | PDB header:cell invasion/cell adhesion Chain: A: PDB Molecule:internalin-a; PDBTitle: crystal structure of inla s192n y369s/mec1 complex
9 | c2z64A_ |
|  | 100.0 | 16 | PDB header:immune system Chain: A: PDB Molecule:toll-like receptor 4; PDBTitle: crystal structure of mouse tlr4 and mouse md-2 complex
10 | c3o6nA_ |
|  | 100.0 | 15 | PDB header:protein binding Chain: A: PDB Molecule:apl1; PDBTitle: crystal structure of apl1 leucine-rich repeat domain
11 | c3fxiA_ |
|  | 99.9 | 15 | PDB header:immune system Chain: A: PDB Molecule:toll-like receptor 4; PDBTitle: crystal structure of the human tlr4-human md-2-e.coli lps ra complex
12 | c1ziwA_ |
|  | 99.9 | 17 | PDB header:immune system Chain: A: PDB Molecule:toll-like receptor 3; PDBTitle: human toll-like receptor 3 extracellular domain structure
13 | c3rg1I_ |
|  | 99.9 | 11 | PDB header:immune system Chain: I: PDB Molecule:cd180 molecule; PDBTitle: crystal structure of the rp105/md-1 complex
14 | c3a79A_ |
|  | 99.9 | 16 | PDB header:immune system Chain: A: PDB Molecule:toll-like receptor 2, variable lymphocyte receptor b; PDBTitle: crystal structure of tlr2-tlr6-pam2csk4 complex
15 | c2a0zA_ |
|  | 99.9 | 18 | PDB header:immune system Chain: A: PDB Molecule:toll-like receptor 3; PDBTitle: the molecular structure of toll-like receptor 3 ligand binding domain
16 | c2z7xB_ |
|  | 99.9 | 18 | PDB header:immune system Chain: B: PDB Molecule:toll-like receptor 1, variable lymphocyte receptor b; PDBTitle: crystal structure of the tlr1-tlr2 heterodimer induced by binding of a2 tri-acylated lipopeptide
17 | c3a79B_ |
|  | 99.9 | 15 | PDB header:immune system Chain: B: PDB Molecule:toll-like receptor 6, variable lymphocyte receptor b; PDBTitle: crystal structure of tlr2-tlr6-pam2csk4 complex
18 | c3rgxA_ |
|  | 99.9 | 21 | PDB header:transferase Chain: A: PDB Molecule:protein brassinosteroid insensitive 1; PDBTitle: structural insight into brassinosteroid perception by bri1
19 | c2z81A_ |
|  | 99.9 | 16 | PDB header:immune system Chain: A: PDB Molecule:toll-like receptor 2, variable lymphocyte receptor b; PDBTitle: crystal structure of the tlr1-tlr2 heterodimer induced by binding of a2 tri-acylated lipopeptide
20 | c2z80A_ |
|  | 99.9 | 15 | PDB header:immune system Chain: A: PDB Molecule:toll-like receptor 2, variable lymphocyte receptor b; PDBTitle: crystal structure of the tlr1-tlr2 heterodimer induced by binding of a2 tri-acylated lipopeptide
21 | c1g9uA_ |
| not modelled | 99.9 | 13 | PDB header:toxin Chain: A: PDB Molecule:outer protein yopm; PDBTitle: crystal structure of yopm-leucine rich effector protein from yersinia2 pestis
22 | d1jl5a_ |
| not modelled | 99.9 | 13 | Fold:Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) Superfamily:L domain-like Family:Leucine rich effector protein YopM
23 | c3bz5A_ |
| not modelled | 99.9 | 13 | PDB header:cell adhesion Chain: A: PDB Molecule:internalin-j; PDBTitle: functional domain of inlj from listeria monocytogenes2 includes a cysteine ladder
24 | c3j0aB_ |
| not modelled | 99.9 | 15 | PDB header:immune system Chain: B: PDB Molecule:toll-like receptor 5; PDBTitle: homology model of human toll-like receptor 5 fitted into an electron2 microscopy single particle reconstruction
25 | d1ogqa_ |
| not modelled | 99.9 | 13 | Fold:Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) Superfamily:L domain-like Family:Polygalacturonase inhibiting protein PGIP
26 | d1p9ag_ |
| not modelled | 99.9 | 19 | Fold:Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) Superfamily:L domain-like Family:Ngr ectodomain-like
27 | c2z62A_ |
| not modelled | 99.9 | 14 | PDB header:immune system Chain: A: PDB Molecule:toll-like receptor 4, variable lymphocyte receptor b; PDBTitle: crystal structure of the tv3 hybrid of human tlr4 and hagfish vlrb.61
28 | c2o6qA_ |
| not modelled | 99.9 | 19 | PDB header:immune system Chain: A: PDB Molecule:variable lymphocyte receptor a; PDBTitle: structural diversity of the hagfish variable lymphocyte2 receptors a29
29 | c3m18A_ |
| not modelled | 99.8 | 16 | PDB header:immune system Chain: A: PDB Molecule:variable lymphocyte receptor a diversity region; PDBTitle: crystal structure of variable lymphocyte receptor vlra.r2.1 in complex2 with hen egg lysozyme
30 | c3o53A_ |
| not modelled | 99.8 | 16 | PDB header:protein binding Chain: A: PDB Molecule:protein lrim1; PDBTitle: crystal structure of lrim1 leucine-rich repeat domain
31 | d1xwdc1 |
| not modelled | 99.8 | 11 | Fold:Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) Superfamily:L domain-like Family:Ngr ectodomain-like
32 | c1ookG_ |
| not modelled | 99.8 | 15 | PDB header:hydrolase Chain: G: PDB Molecule:platelet glycoprotein ib alpha chain precursor; PDBTitle: crystal structure of the complex of platelet receptor gpib-alpha and2 human alpha-thrombin
33 | c3ojaA_ |
| not modelled | 99.8 | 16 | PDB header:protein binding Chain: A: PDB Molecule:leucine-rich immune molecule 1; PDBTitle: crystal structure of lrim1/apl1c complex
34 | c3g04C_ |
| not modelled | 99.8 | 17 | PDB header:immune system Chain: C: PDB Molecule:thyrotropin receptor; PDBTitle: crystal structure of the tsh receptor in complex with a thyroid-2 stimulating autoantibody
35 | d2bnha_ |
| not modelled | 99.8 | 10 | Fold:Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) Superfamily:RNI-like Family:28-residue LRR
36 | c1m9sA_ |
| not modelled | 99.8 | 15 | PDB header:signaling protein Chain: A: PDB Molecule:internalin b; PDBTitle: crystal structure of internalin b (inlb), a listeria2 monocytogenes virulence protein containing sh3-like3 domains.
37 | d1ozna_ |
| not modelled | 99.8 | 12 | Fold:Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) Superfamily:L domain-like Family:Ngr ectodomain-like
38 | c3e6jA_ |
| not modelled | 99.8 | 23 | PDB header:immune system Chain: A: PDB Molecule:variable lymphocyte receptor diversity region; PDBTitle: crystal structure of variable lymphocyte receptor (vlr) rbc36 in2 complex with h-trisaccharide
39 | c1h6uA_ |
| not modelled | 99.8 | 14 | PDB header:cell adhesion Chain: A: PDB Molecule:internalin h; PDBTitle: internalin h: crystal structure of fused n-terminal2 domains.
40 | c3g06A_ |
| not modelled | 99.8 | 16 | PDB header:ligase Chain: A: PDB Molecule:ssph2 (leucine-rich repeat protein); PDBTitle: the salmonella virulence effector ssph2 functions as a2 novel e3 ligase
41 | c1ltxA_ |
| not modelled | 99.8 | 27 | PDB header:transferase/protein binding Chain: A: PDB Molecule:rab geranylgeranyltransferase alpha subunit; PDBTitle: structure of rab escort protein-1 in complex with rab2 geranylgeranyl transferase and isoprenoid
42 | c2y5qA_ |
| not modelled | 99.8 | 23 | PDB header:protein binding Chain: A: PDB Molecule:internalin b; PDBTitle: listeria monocytogenes inlb (internalin b) residues 36-392
43 | c2o6sA_ |
| not modelled | 99.8 | 21 | PDB header:immune system Chain: A: PDB Molecule:variable lymphocyte receptor b; PDBTitle: structural diversity of the hagfish variable lymphocyte2 receptors b59
44 | d1z7xw1 |
| not modelled | 99.8 | 7 | Fold:Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) Superfamily:RNI-like Family:28-residue LRR
45 | d1h6ua2 |
| not modelled | 99.8 | 18 | Fold:Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) Superfamily:L domain-like Family:Internalin LRR domain
46 | c1otnA_ |
| not modelled | 99.7 | 10 | PDB header:cell adhesion Chain: A: PDB Molecule:internalin b; PDBTitle: calcium-binding mutant of the internalin b lrr domain
47 | c3cvrA_ |
| not modelled | 99.7 | 24 | PDB header:ligase Chain: A: PDB Molecule:invasion plasmid antigen; PDBTitle: crystal structure of the full length ipah3
48 | c2z66A_ |
| not modelled | 99.7 | 14 | PDB header:immune system Chain: A: PDB Molecule:variable lymphocyte receptor b, toll-like receptor 4; PDBTitle: crystal structure of the vt3 hybrid of human tlr4 and hagfish vlrb.61
49 | c2xotA_ |
| not modelled | 99.7 | 20 | PDB header:cell adhesion Chain: A: PDB Molecule:amphoterin-induced protein 1; PDBTitle: crystal structure of neuronal leucine rich repeat protein amigo-1
50 | c2uzyA_ |
| not modelled | 99.7 | 18 | PDB header:signaling protein/receptor Chain: A: PDB Molecule:internalin b; PDBTitle: structure of the human receptor tyrosine kinase met in2 complex with the listeria monocytogenes invasion protein3 inlb: low resolution, crystal form ii
51 | d2ca6a1 |
| not modelled | 99.7 | 10 | Fold:Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) Superfamily:RNI-like Family:Rna1p (RanGAP1), N-terminal domain
52 | c1k5dL_ |
| not modelled | 99.7 | 9 | PDB header:signaling protein/signaling activator Chain: L: PDB Molecule:ran gtpase activating protein 1; PDBTitle: crystal structure of ran-gppnhp-ranbp1-rangap complex
53 | d1h6ta2 |
| not modelled | 99.7 | 21 | Fold:Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) Superfamily:L domain-like Family:Internalin LRR domain
54 | c1xeuA_ |
| not modelled | 99.7 | 23 | PDB header:cell invasion Chain: A: PDB Molecule:internalin c; PDBTitle: crystal structure of internalin c from listeria2 monocytogenes
55 | d2omxa2 |
| not modelled | 99.6 | 22 | Fold:Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) Superfamily:L domain-like Family:Internalin LRR domain
56 | c3gozA_ |
| not modelled | 99.6 | 13 | PDB header:structural genomics, unknown function Chain: A: PDB Molecule:leucine-rich repeat-containing protein; PDBTitle: crystal structure of the leucine-rich repeat-containing2 protein legl7 from legionella pneumophila. northeast3 structural genomics consortium target lgr148
57 | c2r9uC_ |
| not modelled | 99.6 | 22 | PDB header:immune system Chain: C: PDB Molecule:variable lymphocyte receptor; PDBTitle: crystal structure of lamprey variable lymphocyte receptor 29132 ectodomain
58 | c1wwlA_ |
| not modelled | 99.6 | 18 | PDB header:immune system Chain: A: PDB Molecule:monocyte differentiation antigen cd14; PDBTitle: crystal structure of cd14
59 | c2v9sC_ |
| not modelled | 99.5 | 16 | PDB header:structural protein Chain: C: PDB Molecule:slit homolog 2 protein n-product; PDBTitle: second lrr domain of human slit2
60 | c2o6rA_ |
| not modelled | 99.5 | 37 | PDB header:immune system Chain: A: PDB Molecule:variable lymphocyte receptor b; PDBTitle: structural diversity of the hagfish variable lymphocyte2 receptors b61
61 | c2v70D_ |
| not modelled | 99.5 | 17 | PDB header:structural protein Chain: D: PDB Molecule:slit homolog 2 protein n-product; PDBTitle: third lrr domain of human slit2
62 | c2wfhB_ |
| not modelled | 99.5 | 15 | PDB header:splicing Chain: B: PDB Molecule:slit homolog 2 protein c-product; PDBTitle: the human slit 2 dimerization domain d4
63 | d1w8aa_ |
| not modelled | 99.5 | 21 | Fold:Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) Superfamily:L domain-like Family:Ngr ectodomain-like
64 | c2ifgB_ |
| not modelled | 99.4 | 18 | PDB header:transferase Chain: B: PDB Molecule:high affinity nerve growth factor receptor; PDBTitle: structure of the extracellular segment of human trka in complex with2 nerve growth factor
65 | d2astb2 |
| not modelled | 99.4 | 16 | Fold:Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) Superfamily:RNI-like Family:Cyclin A/CDK2-associated p19, Skp2
66 | c3g3aA_ |
| not modelled | 99.4 | 22 | PDB header:hydrolase/immune system Chain: A: PDB Molecule:variable lymphocyte receptor vlrb.2d; PDBTitle: structure of a lamprey variable lymphocyte receptor in2 complex with a protein antigen
67 | d1dcea3 |
| not modelled | 99.4 | 42 | Fold:Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) Superfamily:L domain-like Family:Rab geranylgeranyltransferase alpha-subunit, C-terminal domain
68 | c2je0E_ |
| not modelled | 99.3 | 21 | PDB header:nuclear protein Chain: E: PDB Molecule:acidic leucine-rich nuclear phosphoprotein 32 family PDBTitle: crystal structure of pp32
69 | d1fs2a2 |
| not modelled | 99.2 | 20 | Fold:Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) Superfamily:RNI-like Family:Cyclin A/CDK2-associated p19, Skp2
70 | c2ra8A_ |
| not modelled | 99.0 | 15 | PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein q64v53_bacfr; PDBTitle: crystal structure of the q64v53_bacfr protein from bacteroides2 fragilis. northeast structural genomics consortium target bfr43
71 | c3sb4B_ |
| not modelled | 99.0 | 12 | PDB header:protein binding Chain: B: PDB Molecule:hypothetical leucine rich repeat protein; PDBTitle: crystal structure of a hypothetical leucine rich repeat protein2 (bt_1240) from bacteroides thetaiotaomicron vpi-5482 at 1.99 a3 resolution
72 | d1a9na_ |
| not modelled | 99.0 | 16 | Fold:Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) Superfamily:L domain-like Family:U2A'-like
73 | d2ifga3 |
| not modelled | 99.0 | 18 | Fold:Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) Superfamily:L domain-like Family:Ngr ectodomain-like
74 | d1m9la_ |
| not modelled | 98.5 | 19 | Fold:Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) Superfamily:Outer arm dynein light chain 1 Family:Outer arm dynein light chain 1
75 | c3rfeB_ |
| not modelled | 98.3 | 16 | PDB header:cell adhesion Chain: B: PDB Molecule:platelet glycoprotein ib beta chain; PDBTitle: crystal structure of glycoprotein gpib ectodomain
76 | c3oglD_ |
| not modelled | 98.2 | 9 | PDB header:protein binding Chain: D: PDB Molecule:coronatine-insensitive protein 1; PDBTitle: structure of coi1-ask1 in complex with ja-isoleucine and the jaz12 degron
77 | c3ogmB_ |
| not modelled | 98.2 | 9 | PDB header:protein binding Chain: B: PDB Molecule:coronatine-insensitive protein 1; PDBTitle: structure of coi1-ask1 in complex with coronatine and the jaz1 degron
78 | c1kooD_ |
| not modelled | 98.2 | 20 | PDB header:rna binding protein Chain: D: PDB Molecule:tip associating protein; PDBTitle: the crystal structure and mutational analysis of a novel2 rna-binding domain found in the human tap nuclear mrna3 export factor
79 | c2p1nE_ |
| not modelled | 98.0 | 8 | PDB header:signaling protein Chain: E: PDB Molecule:transport inhibitor response 1 protein; PDBTitle: mechanism of auxin perception by the tir1 ubiqutin ligase
80 | d1koha1 |
| not modelled | 97.9 | 20 | Fold:Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) Superfamily:L domain-like Family:mRNA export factor tap
81 | c1fqvK_ |
| not modelled | 97.3 | 15 | PDB header:ligase Chain: K: PDB Molecule:skp2; PDBTitle: insights into scf ubiquitin ligases from the structure of2 the skp1-skp2 complex
82 | c3e2jA_ |
| not modelled | 97.3 | 14 | PDB header:electron transport Chain: A: PDB Molecule:atp synthase subunit s, mitochondrial; PDBTitle: crystal structure of bovine coupling factor b
83 | d1io0a_ |
| not modelled | 95.7 | 18 | Fold:Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) Superfamily:RNI-like Family:28-residue LRR
84 | d1pgva_ |
| not modelled | 95.5 | 12 | Fold:Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) Superfamily:RNI-like Family:28-residue LRR

Binding site prediction |

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
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Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0