BLASTP 2.2.22 [Sep-27-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= batch____ (363 letters) Database: uniref50.fasta 3,077,464 sequences; 1,040,396,356 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value UniRef50_Q4QLS3 3-isopropylmalate dehydrogenase n=43 Tax=Bacteri... 538 e-151 UniRef50_Q493R1 3-isopropylmalate dehydrogenase n=224 Tax=Bacter... 487 e-136 UniRef50_Q47WG3 3-isopropylmalate dehydrogenase n=20 Tax=Bacteri... 471 e-131 UniRef50_Q9WZ26 3-isopropylmalate dehydrogenase n=47 Tax=Bacteri... 409 e-112 UniRef50_Q9FMT1 3-isopropylmalate dehydrogenase 3, chloroplastic... 357 6e-97 UniRef50_D1HRU7 3-isopropylmalate dehydrogenase (Fragment) n=2 T... 353 5e-96 UniRef50_C9KJM9 3-isopropylmalate dehydrogenase n=1 Tax=Mitsuoke... 339 8e-92 UniRef50_Q6GF15 3-isopropylmalate dehydrogenase n=94 Tax=Bacilli... 333 5e-90 UniRef50_Q5SIY4 3-isopropylmalate dehydrogenase n=53 Tax=cellula... 333 7e-90 UniRef50_Q2VZV2 3-isopropylmalate dehydrogenase n=35 Tax=Bacteri... 332 1e-89 UniRef50_Q2J3B4 3-isopropylmalate dehydrogenase n=132 Tax=Bacter... 328 3e-88 UniRef50_Q2K2V0 3-isopropylmalate dehydrogenase n=11 Tax=Alphapr... 323 8e-87 UniRef50_Q2YL58 3-isopropylmalate dehydrogenase n=285 Tax=cellul... 322 2e-86 UniRef50_Q5HMF8 3-isopropylmalate dehydrogenase n=9 Tax=Bacilli ... 319 8e-86 UniRef50_Q4FP17 3-isopropylmalate dehydrogenase n=11 Tax=cellula... 312 1e-83 UniRef50_Q81G11 3-isopropylmalate dehydrogenase n=105 Tax=Bacter... 311 2e-83 UniRef50_Q2RV53 3-isopropylmalate dehydrogenase n=103 Tax=Bacter... 309 1e-82 UniRef50_Q5LAB4 3-isopropylmalate dehydrogenase n=58 Tax=Bacteri... 306 6e-82 UniRef50_Q1ARE1 3-isopropylmalate dehydrogenase n=2 Tax=Bacteria... 306 1e-81 UniRef50_D0J9Z6 3-isopropylmalate dehydrogenase n=7 Tax=Bacteroi... 305 2e-81 UniRef50_Q05FQ8 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 291 3e-77 UniRef50_P04173 3-isopropylmalate dehydrogenase n=61 Tax=Fungi/M... 278 2e-73 UniRef50_Q12545 3-isopropylmalate dehydrogenase n=54 Tax=cellula... 270 5e-71 UniRef50_O59930 3-isopropylmalate dehydrogenase n=12 Tax=cellula... 265 2e-69 UniRef50_A1SWV5 3-isopropylmalate dehydrogenase n=1 Tax=Psychrom... 264 4e-69 UniRef50_P34738 3-isopropylmalate dehydrogenase n=8 Tax=cellular... 261 2e-68 UniRef50_D0DDG4 3-isopropylmalate dehydrogenase n=1 Tax=Citreice... 234 3e-60 UniRef50_B8M3W0 3-isopropylmalate dehydrogenase n=6 Tax=Leotiomy... 234 3e-60 UniRef50_B1I496 3-isopropylmalate dehydrogenase n=4 Tax=Bacteria... 233 8e-60 UniRef50_B2J8P1 3-isopropylmalate dehydrogenase n=3 Tax=Cyanobac... 232 2e-59 UniRef50_Q4P2R4 3-isopropylmalate dehydrogenase n=1 Tax=Ustilago... 229 1e-58 UniRef50_Q6W109 Tartrate dehydrogenase n=13 Tax=Bacteria RepID=Q... 228 3e-58 UniRef50_C5EHC0 3-isopropylmalate dehydrogenase n=1 Tax=Clostrid... 225 2e-57 UniRef50_O29627 3-isopropylmalate dehydrogenase n=91 Tax=cellula... 221 4e-56 UniRef50_A3P147 Tartrate dehydrogenase n=59 Tax=Bacteria RepID=A... 220 6e-56 UniRef50_A4IK21 Tartrate dehydrogenase n=7 Tax=Bacillaceae RepID... 215 2e-54 UniRef50_Q2JYV7 Probable tartrate dehydrogenase protein n=7 Tax=... 214 5e-54 UniRef50_Q47SB4 3-isopropylmalate dehydrogenase n=15 Tax=cellula... 213 1e-53 UniRef50_O27441 3-isopropylmalate dehydrogenase n=30 Tax=Archaea... 212 2e-53 UniRef50_Q46NL2 Tartrate dehydrogenase n=12 Tax=Bacteria RepID=Q... 208 2e-52 UniRef50_A6WAX5 3-isopropylmalate dehydrogenase n=20 Tax=Bacteri... 208 2e-52 UniRef50_D2SEJ6 3-isopropylmalate dehydrogenase n=3 Tax=Actinomy... 207 7e-52 UniRef50_Q7UTP0 3-isopropylmalate dehydrogenase n=1 Tax=Rhodopir... 206 9e-52 UniRef50_B1MJY2 Tartrate dehydrogenase n=5 Tax=Bacteria RepID=B1... 204 4e-51 UniRef50_B3TCK6 Putative isocitrate/isopropylmalate dehydrogenas... 203 9e-51 UniRef50_UPI0001B4F4BD putative isocitrate/isopropylmalate dehyd... 203 1e-50 UniRef50_C3MI61 3-isopropylmalate dehydrogenase n=13 Tax=Proteob... 202 2e-50 UniRef50_Q2HAA2 Putative uncharacterized protein n=2 Tax=Chaetom... 201 3e-50 UniRef50_C7RJH9 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 200 7e-50 UniRef50_B0RIP4 3-isopropylmalate dehydrogenase n=140 Tax=Bacter... 199 2e-49 UniRef50_A5UMS5 3-isopropylmalate dehydrogenase, LeuB n=8 Tax=Eu... 198 3e-49 UniRef50_P42958 Probable tartrate dehydrogenase/decarboxylase n=... 198 3e-49 UniRef50_Q46FW0 3-isopropylmalate dehydrogenase n=11 Tax=Euryarc... 197 4e-49 UniRef50_UPI0001C310FF Tartrate decarboxylase n=1 Tax=Conexibact... 197 5e-49 UniRef50_B0ER68 Tartrate dehydrogenase, putative n=2 Tax=Entamoe... 196 9e-49 UniRef50_B8N3I6 Tartrate dehydrogenase, putative n=3 Tax=Trichoc... 195 2e-48 UniRef50_Q58991 Homoisocitrate dehydrogenase n=21 Tax=Euryarchae... 194 6e-48 UniRef50_A8TPC9 3-isopropylmalate dehydrogenase n=3 Tax=Alphapro... 191 3e-47 UniRef50_D2EFL9 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 191 4e-47 UniRef50_B1L3C1 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 190 6e-47 UniRef50_Q0A635 Isocitrate/isopropylmalate dehydrogenase n=1 Tax... 189 1e-46 UniRef50_Q0W5L4 3-isopropylmalate dehydrogenase n=14 Tax=root Re... 189 1e-46 UniRef50_Q5JFV8 Homoisocitrate dehydrogenase n=4 Tax=Thermococca... 189 2e-46 UniRef50_P70787 Probable tartrate dehydrogenase/decarboxylase tt... 187 5e-46 UniRef50_Q0X0C1 Putative dehydrogenase n=2 Tax=Streptomyces RepI... 187 7e-46 UniRef50_A5US63 Homoisocitrate dehydrogenase n=6 Tax=Chloroflexi... 183 9e-45 UniRef50_Q51945 Tartrate dehydrogenase/decarboxylase n=249 Tax=c... 182 1e-44 UniRef50_Q2JUI3 Isopropylmalate/isohomocitrate dehydrogenase fam... 181 3e-44 UniRef50_Q1IJA8 Isocitrate dehydrogenase (NAD+) n=19 Tax=Bacteri... 179 1e-43 UniRef50_C1XGT6 Homoisocitrate dehydrogenase n=1 Tax=Meiothermus... 174 4e-42 UniRef50_D0RN50 Threo-isocitrate dehydrogenase [NAD] n=1 Tax=alp... 174 5e-42 UniRef50_Q5SIJ1 Homoisocitrate dehydrogenase n=13 Tax=cellular o... 172 1e-41 UniRef50_D1B742 3-isopropylmalate dehydrogenase n=2 Tax=Synergis... 171 4e-41 UniRef50_A9IDG2 Tartrate dehydrogenase n=5 Tax=cellular organism... 171 5e-41 UniRef50_Q55BI2 Isocitrate dehydrogenase [NAD] regulatory subuni... 169 2e-40 UniRef50_B9KYU3 Isocitrate dehydrogenase (NADP) n=3 Tax=Bacteria... 168 3e-40 UniRef50_D0LNY3 3-isopropylmalate dehydrogenase n=1 Tax=Haliangi... 168 3e-40 UniRef50_P33197 Isocitrate dehydrogenase [NADP] n=10 Tax=Bacteri... 167 7e-40 UniRef50_A0P1S6 3-isopropylmalate dehydrogenase n=3 Tax=Rhodobac... 166 1e-39 UniRef50_A5FXZ9 3-isopropylmalate dehydrogenase n=2 Tax=Alphapro... 165 2e-39 UniRef50_A9FME3 3-isopropylmalate dehydrogenase n=7 Tax=Proteoba... 165 3e-39 UniRef50_D2VFR4 Homo-isocitrate dehydrogenase n=1 Tax=Naegleria ... 165 3e-39 UniRef50_C7MQT6 Isocitrate/isopropylmalate dehydrogenase n=1 Tax... 163 9e-39 UniRef50_P40495 Homoisocitrate dehydrogenase, mitochondrial n=66... 162 1e-38 UniRef50_A1WHK9 3-isopropylmalate dehydrogenase n=5 Tax=Proteoba... 160 7e-38 UniRef50_Q1RJU4 Isocitrate dehydrogenase [NADP] n=62 Tax=cellula... 156 9e-37 UniRef50_P50213 Isocitrate dehydrogenase [NAD] subunit alpha, mi... 156 1e-36 UniRef50_Q18GT1 3-isopropylmalate dehydrogenase n=8 Tax=Halobact... 155 3e-36 UniRef50_Q8XSY8 Probable 3-isopropylmalate dehydrogenase oxidore... 154 5e-36 UniRef50_C7YX79 Putative uncharacterized protein (Fragment) n=1 ... 152 2e-35 UniRef50_A1WV93 3-isopropylmalate dehydrogenase n=8 Tax=Gammapro... 149 1e-34 UniRef50_Q0BQF4 Isocitrate dehydrogenase (NADP) n=14 Tax=Proteob... 148 3e-34 UniRef50_UPI000150AB37 dehydrogenase, isocitrate/isopropylmalate... 147 7e-34 UniRef50_Q1IMD5 3-isopropylmalate dehydrogenase n=3 Tax=cellular... 146 1e-33 UniRef50_C4Q3D3 Unc-13 (Munc13), putative n=38 Tax=cellular orga... 144 4e-33 UniRef50_A5CDH3 Isocitrate dehydrogenase, NADP-dependent n=7 Tax... 144 5e-33 UniRef50_Q4ZRW7 3-isopropylmalate dehydrogenase n=13 Tax=Proteob... 142 2e-32 UniRef50_P28834 Isocitrate dehydrogenase [NAD] subunit 1, mitoch... 140 8e-32 UniRef50_A6G3V7 Probable 3-isopropylmalate dehydrogenase n=2 Tax... 139 1e-31 UniRef50_B1L5I7 Isocitrate dehydrogenase (NAD(+)) n=1 Tax=Candid... 139 2e-31 UniRef50_A9A2N6 Isocitrate dehydrogenase (NAD(+)) n=11 Tax=Archa... 139 2e-31 UniRef50_D2SD16 Malate/L-lactate dehydrogenase n=1 Tax=Geodermat... 139 2e-31 UniRef50_D1B6F8 3-isopropylmalate dehydrogenase n=1 Tax=Thermana... 139 2e-31 UniRef50_Q0D0R7 Isocitrate dehydrogenase subunit 2, mitochondria... 137 7e-31 UniRef50_B8NJA6 3-isopropymalate dehydrogenase, putative n=3 Tax... 137 7e-31 UniRef50_UPI000038E0FC 3-isopropylmalate dehydrogenase n=1 Tax=F... 136 1e-30 UniRef50_A9QPI0 Isocitrate/isopropylmalate dehydrogenase n=3 Tax... 136 1e-30 UniRef50_B8FQF2 Isocitrate/isopropylmalate dehydrogenase n=2 Tax... 136 1e-30 UniRef50_A4FEJ6 3-isopropylmalate dehydrogenase n=1 Tax=Saccharo... 135 2e-30 UniRef50_P28241 Isocitrate dehydrogenase [NAD] subunit 2, mitoch... 134 7e-30 UniRef50_C9SEZ4 Homoisocitrate dehydrogenase n=1 Tax=Verticilliu... 133 8e-30 UniRef50_C6V444 Isocitrate dehydrogenase n=2 Tax=Neorickettsia R... 132 2e-29 UniRef50_UPI000185C11E 3-isopropylmalate dehydrogenase n=1 Tax=C... 128 3e-28 UniRef50_A9UQS3 Predicted protein n=1 Tax=Monosiga brevicollis R... 128 4e-28 UniRef50_C1F3J9 Isocitrate dehydrogenase n=1 Tax=Acidobacterium ... 127 9e-28 UniRef50_Q0ZQ44 FrbE n=1 Tax=Streptomyces rubellomurinus RepID=Q... 125 2e-27 UniRef50_Q6L0K7 3-isopropylmalate dehydrogenase n=1 Tax=Picrophi... 125 2e-27 UniRef50_Q48806 Protein dlpA n=5 Tax=Legionella RepID=DLPA_LEGPH 125 3e-27 UniRef50_Q5P9Q1 Isocitrate dehydrogenase n=13 Tax=Rickettsiales ... 123 1e-26 UniRef50_P96318 Isocitrate dehydrogenase [NADP] n=5 Tax=cellular... 122 1e-26 UniRef50_A4WLX6 Isocitrate dehydrogenase (NADP) n=22 Tax=Archaea... 119 2e-25 UniRef50_O43837 Isocitrate dehydrogenase [NAD] subunit beta, mit... 117 5e-25 UniRef50_B7PN53 Isocitrate dehydrogenase, putative (Fragment) n=... 117 8e-25 UniRef50_C4QCG1 Isocitrate dehydrogenase [NAD] subunit gamma, mi... 116 1e-24 UniRef50_A7SJV9 Predicted protein n=1 Tax=Nematostella vectensis... 116 1e-24 UniRef50_A0D2B8 Chromosome undetermined scaffold_35, whole genom... 115 2e-24 UniRef50_P41564 Isocitrate dehydrogenase [NAD] subunit gamma, mi... 115 2e-24 UniRef50_P51553 Isocitrate dehydrogenase [NAD] subunit gamma, mi... 115 3e-24 UniRef50_C5GTE7 Tartrate dehydrogenase n=2 Tax=Ajellomyces derma... 114 4e-24 UniRef50_O67480 Isocitrate dehydrogenase [NADP] n=5 Tax=Aquifica... 114 6e-24 UniRef50_O81796 Isocitrate dehydrogenase [NAD] regulatory subuni... 113 9e-24 UniRef50_B3RY01 Putative uncharacterized protein n=1 Tax=Trichop... 111 4e-23 UniRef50_B4PZH5 GE17383 n=3 Tax=Drosophila RepID=B4PZH5_DROYA 111 5e-23 UniRef50_UPI0001AF2578 isocitrate dehydrogenase [NADP] (oxalosuc... 110 1e-22 UniRef50_D2Y061 Isocitrate dehydrogenase n=1 Tax=Bombyx mori Rep... 110 1e-22 UniRef50_UPI00016C59BF Isocitrate dehydrogenase (NAD+) n=1 Tax=G... 108 3e-22 UniRef50_UPI00019260EC PREDICTED: similar to predicted protein i... 108 4e-22 UniRef50_O15384 NAD (H)-specific isocitrate dehydrogenase gamma ... 105 2e-21 UniRef50_A9KQX3 Isocitrate dehydrogenase (NAD(+)) n=5 Tax=cellul... 105 2e-21 UniRef50_Q9U6V3 Isocitrate dehydrogenase gamma subunit n=4 Tax=B... 103 8e-21 UniRef50_O13696 Isocitrate dehydrogenase [NAD] subunit 1, mitoch... 103 9e-21 UniRef50_C7P3E9 Isocitrate dehydrogenase, NADP-dependent n=5 Tax... 103 1e-20 UniRef50_Q6GG12 Isocitrate dehydrogenase [NADP] n=90 Tax=root Re... 103 1e-20 UniRef50_C7YNU4 Putative uncharacterized protein n=1 Tax=Nectria... 101 4e-20 UniRef50_A6GJ83 Isocitrate dehydrogenase n=1 Tax=Plesiocystis pa... 100 2e-19 UniRef50_D2RVT1 Isocitrate dehydrogenase, NADP-dependent n=1 Tax... 99 3e-19 UniRef50_A9B3D4 Isocitrate/isopropylmalate dehydrogenase n=4 Tax... 98 5e-19 UniRef50_D2VM48 Isocitrate dehydrogenase n=1 Tax=Naegleria grube... 97 1e-18 UniRef50_Q3IKZ8 Isocitrate dehydrogenase, specific for NADP+ n=3... 95 4e-18 UniRef50_UPI000186E03D isocitrate dehydrogenase, putative n=1 Ta... 93 2e-17 UniRef50_A8E541 Idh3a protein n=4 Tax=Euteleostomi RepID=A8E541_... 92 3e-17 UniRef50_UPI0001910A87 3-isopropylmalate dehydrogenase n=1 Tax=S... 91 1e-16 UniRef50_A5BNI3 Putative uncharacterized protein n=1 Tax=Vitis v... 90 2e-16 UniRef50_C0WN79 Isocitrate dehydrogenase [NADP] n=4 Tax=Lactobac... 89 2e-16 UniRef50_B0BZF3 Isocitrate dehydrogenase NAD-dependent n=1 Tax=A... 89 2e-16 UniRef50_B4MP27 GK19462 n=1 Tax=Drosophila willistoni RepID=B4MP... 87 1e-15 UniRef50_Q9ZN36 Isocitrate dehydrogenase [NADP] n=932 Tax=root R... 86 2e-15 UniRef50_D2RML7 Isocitrate/isopropylmalate dehydrogenase n=6 Tax... 84 1e-14 UniRef50_Q8KH40 LeuB (Fragment) n=3 Tax=Buchnera aphidicola RepI... 83 2e-14 UniRef50_C0W9Q2 Isocitrate dehydrogenase n=2 Tax=Clostridiales R... 82 2e-14 UniRef50_B7UV18 Isocitrate dehydrogenase [NADP] n=9 Tax=Gammapro... 82 3e-14 UniRef50_C7GAF7 3-isopropylmalate dehydrogenase (Fragment) n=1 T... 82 3e-14 UniRef50_B1VH60 Putative dehydrogenase n=1 Tax=Corynebacterium u... 82 4e-14 UniRef50_B6QRT7 3-isopropylmalate dehydrogenase, putative n=1 Ta... 81 6e-14 UniRef50_Q84AT8 LeuB (Fragment) n=1 Tax=Buchnera aphidicola RepI... 79 3e-13 UniRef50_Q03UU7 3-isopropylmalate dehydrogenase n=4 Tax=Leuconos... 77 1e-12 UniRef50_B5RJP2 FI08066p (Fragment) n=18 Tax=Sophophora RepID=B5... 76 2e-12 UniRef50_UPI00017936A6 PREDICTED: similar to isocitrate dehydrog... 72 3e-11 UniRef50_Q961P4 GH13226p n=4 Tax=Drosophila RepID=Q961P4_DROME 71 6e-11 UniRef50_B7KHW3 Isocitrate/isopropylmalate dehydrogenase n=11 Ta... 67 8e-10 UniRef50_C1GSN2 3-isopropylmalate dehydrogenase n=4 Tax=Onygenal... 67 8e-10 UniRef50_UPI0001C163C2 Isocitrate dehydrogenase NADP-dependent, ... 66 2e-09 UniRef50_B1XUL5 Tartrate dehydrogenase n=1 Tax=Polynucleobacter ... 64 7e-09 UniRef50_UPI0001C31665 isocitrate/isopropylmalate dehydrogenase ... 64 1e-08 UniRef50_P41560 Isocitrate dehydrogenase [NADP] 1 n=78 Tax=cellu... 64 1e-08 UniRef50_P80046 Isocitrate dehydrogenase [NADP] n=54 Tax=cellula... 61 6e-08 UniRef50_UPI0001AF5761 3-isopropylmalate dehydrogenase n=1 Tax=P... 60 1e-07 UniRef50_Q1G324 Putative uncharacterized protein n=1 Tax=Arabido... 58 4e-07 UniRef50_UPI00003C8595 isocitrate dehydrogenase n=1 Tax=Ferropla... 58 7e-07 UniRef50_A3RRN5 Tartrate dehydrogenase n=3 Tax=Ralstonia solanac... 55 3e-06 UniRef50_UPI00017440F3 Isocitrate dehydrogenase (NAD(+)) n=1 Tax... 54 6e-06 UniRef50_D0WIJ5 Isocitrate dehydrogenase, NADP-dependent n=2 Tax... 53 1e-05 UniRef50_B5DZV4 GA24694 n=6 Tax=Drosophila RepID=B5DZV4_DROPS 48 5e-04 UniRef50_D0DDP2 3-isopropylmalate dehydrogenase n=1 Tax=Citreice... 48 6e-04 UniRef50_B6QD56 Putative uncharacterized protein n=1 Tax=Penicil... 47 0.001 UniRef50_Q8T494 AT08722p n=1 Tax=Drosophila melanogaster RepID=Q... 44 0.009 UniRef50_A4SBK5 Predicted protein n=6 Tax=Eukaryota RepID=A4SBK5... 42 0.027 UniRef50_Q7X199 Lfe195p1 (Fragment) n=4 Tax=Leptospirillum RepID... 42 0.028 >UniRef50_Q4QLS3 3-isopropylmalate dehydrogenase n=43 Tax=Bacteria RepID=LEU3_HAEI8 Length = 358 Score = 538 bits (1387), Expect = e-151, Method: Compositional matrix adjust. Identities = 254/357 (71%), Positives = 299/357 (83%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATV 62 ++Y++AVL GDGIGPEVM +A+KVL+ V+ +F ++ + + VGGAAID+ G PLP T+ Sbjct: 2 QSYNVAVLAGDGIGPEVMAEAMKVLNKVQEKFGFKLNFNEFFVGGAAIDHCGYPLPAETL 61 Query: 63 EGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 +GC++ADA+LFGSVGGPKW +LPPDQQPERGALLPLRKHFKLF NLRPA LY+GLE FCP Sbjct: 62 KGCDEADAILFGSVGGPKWTNLPPDQQPERGALLPLRKHFKLFCNLRPATLYKGLEKFCP 121 Query: 123 LRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFES 182 LRADIAA GFD++ VRELTGGIYFGQPKGREG G KAFDTEVY+++EIERIAR AFE+ Sbjct: 122 LRADIAAKGFDMVVVRELTGGIYFGQPKGREGEGSQTKAFDTEVYYKYEIERIARAAFEA 181 Query: 183 ARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDV 242 A KR KVTS+DKANVLQSSILWRE V E+A +YP+V L H+YIDNATMQLIK P FDV Sbjct: 182 AMKRNKKVTSVDKANVLQSSILWRETVTEMAKDYPEVTLEHIYIDNATMQLIKAPESFDV 241 Query: 243 LLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQI 302 LLCSN+FGDI+SDE AMITGSMGMLPSASLNE GFGLYEPAGGSAPDIAGK IANPIAQI Sbjct: 242 LLCSNIFGDIISDEAAMITGSMGMLPSASLNEAGFGLYEPAGGSAPDIAGKGIANPIAQI 301 Query: 303 LSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYV 359 LS A++LRYS + ++AA AIE A+ + L G RT DLA + VST EMG +I + + Sbjct: 302 LSAAMMLRYSFNLNEAADAIESAVQKVLASGHRTADLADDSTPVSTAEMGTLITQAI 358 >UniRef50_Q493R1 3-isopropylmalate dehydrogenase n=224 Tax=Bacteria RepID=LEU3_BLOPB Length = 366 Score = 487 bits (1253), Expect = e-136, Method: Compositional matrix adjust. Identities = 227/360 (63%), Positives = 284/360 (78%), Gaps = 1/360 (0%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPA 60 M+ NYHIAVLPGDGIGPE Q K+L+ ++ +F + I T+ + +GG AI++ G P P + Sbjct: 1 MNNNYHIAVLPGDGIGPETTRQVYKILNVIKKQFQINIVTTEHKIGGDAINSEGTPFPKS 60 Query: 61 TVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAF 120 T++ CEQ++A+LFG+VGGP+W HL + PE+GALL LRKHF LF+NLRP L L+ Sbjct: 61 TLKYCEQSNAILFGAVGGPQWTHLKGSESPEQGALLALRKHFNLFANLRPIYLADELKEL 120 Query: 121 CPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAF 180 PL ++ NG DI+ VRELTGGIYFGQPKGR G+G E AFDT VYHRFEIERIA IAF Sbjct: 121 SPLNINMIPNGIDIIFVRELTGGIYFGQPKGRSGTGLNEYAFDTAVYHRFEIERIANIAF 180 Query: 181 ESARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQF 240 + A+KRR +V+SIDKANVL +S+LWRE+V+ +A YPDVEL H+YIDNA+MQLI +PS+F Sbjct: 181 KLAQKRRKRVSSIDKANVLHTSMLWREVVSHLAKNYPDVELEHLYIDNASMQLINNPSKF 240 Query: 241 DVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIA 300 D++LC NLFGDILSDECAMI+GS+GMLPSAS+NE FGLYEPAGGSAPDIA KNIANPIA Sbjct: 241 DIILCPNLFGDILSDECAMISGSIGMLPSASINEHNFGLYEPAGGSAPDIAEKNIANPIA 300 Query: 301 QILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARG-AAAVSTDEMGDIIARYV 359 ILS+ALL RYSL D A IE+A+++AL G RT D+A+ ++ST+EMGDIIA + Sbjct: 301 HILSIALLFRYSLKLDHIAIKIEKAVSQALMLGYRTIDIAKKHEKSISTNEMGDIIAALI 360 >UniRef50_Q47WG3 3-isopropylmalate dehydrogenase n=20 Tax=Bacteria RepID=LEU3_COLP3 Length = 362 Score = 471 bits (1212), Expect = e-131, Method: Compositional matrix adjust. Identities = 223/357 (62%), Positives = 277/357 (77%), Gaps = 3/357 (0%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 +IA+L GDGIGPEVM +A KVL+ V ++F ITT YD+GGAAIDNHG LP +T+ GC Sbjct: 3 NIAILAGDGIGPEVMVEAKKVLNTVASKFDFEITTQDYDIGGAAIDNHGNALPDSTMAGC 62 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 ++DA+LFGSVGGPKW +LPP +QPER ALL LR HF LF N+RPA L L + LR+ Sbjct: 63 IESDAILFGSVGGPKWANLPPTEQPERCALLGLRSHFDLFCNMRPATLQPALSSLSTLRS 122 Query: 126 DIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARK 185 DI+ GFD+L +RELTG IYFG+PKGR G G+ E FD+ Y R E++RI+ +AF++A+K Sbjct: 123 DISEQGFDVLVIRELTGDIYFGEPKGRRGEGEEETGFDSMFYSRREVKRISHLAFQAAQK 182 Query: 186 RRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLLC 245 R +KVTS+DKANVL +S LWR++V E+A EYPDVEL H+Y+DNA MQL++DP+QFDV+LC Sbjct: 183 RNNKVTSVDKANVLATSQLWRQVVEEVAVEYPDVELEHLYVDNAAMQLVRDPNQFDVMLC 242 Query: 246 SNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSL 305 NLFGDILSD CAMITGSMG+LPSASLN GFG+YEPAGGSAPDIAG +ANPIAQILS Sbjct: 243 PNLFGDILSDICAMITGSMGLLPSASLNSDGFGMYEPAGGSAPDIAGLGVANPIAQILSA 302 Query: 306 ALLLRYSLDADDAACAIERAINRALEEGIRTGDLARG---AAAVSTDEMGDIIARYV 359 AL+LRYSL+ AA AIE A++ AL+ G+ T DL A ST E+GD I + + Sbjct: 303 ALMLRYSLNQGAAAKAIEDAVSNALDNGVLTADLLPANERKNAKSTSEVGDYICKQI 359 >UniRef50_Q9WZ26 3-isopropylmalate dehydrogenase n=47 Tax=Bacteria RepID=LEU3_THEMA Length = 354 Score = 409 bits (1050), Expect = e-112, Method: Compositional matrix adjust. Identities = 202/357 (56%), Positives = 259/357 (72%), Gaps = 7/357 (1%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 IAVLPGDGIGPEV+ +ALKVL+ V + +GG AID G+PLP T + C Sbjct: 2 KIAVLPGDGIGPEVVREALKVLEVVEKKTGKTFEKVFGHIGGDAIDRFGEPLPEETKKIC 61 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 +ADA+ GSVGGPKW+ LPP+++PE G LL LRK L++N+RP K+Y+ L PL+ Sbjct: 62 LEADAIFLGSVGGPKWDDLPPEKRPEIGGLLALRKMLNLYANIRPIKVYRSLVHVSPLKE 121 Query: 126 DIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARK 185 + +G D++ VREL+ G+Y+GQP+G + EK FDT +Y R +ERIAR AFE A+ Sbjct: 122 KVIGSGVDLVTVRELSYGVYYGQPRGLD----EEKGFDTMIYDRKTVERIARTAFEIAKN 177 Query: 186 RRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLLC 245 RR KVTS+DKANVL SS+LWR++VNE+A EYPDVEL H+Y+DNA MQLI PSQFDV+L Sbjct: 178 RRKKVTSVDKANVLYSSMLWRKVVNEVAREYPDVELTHIYVDNAAMQLILKPSQFDVILT 237 Query: 246 SNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSL 305 +N+FGDILSDE A + GS+G+LPSAS ++ LYEPAGGSAPDIAGKNIANPIAQILSL Sbjct: 238 TNMFGDILSDESAALPGSLGLLPSASFGDK--NLYEPAGGSAPDIAGKNIANPIAQILSL 295 Query: 306 ALLLRYSLDADDAACAIERAINRALEEGIRTGDLARG-AAAVSTDEMGDIIARYVAE 361 A++L +S + A IERA+ +EEG RT D+A AVST +MGD+I + + E Sbjct: 296 AMMLEHSFGMVEEARKIERAVELVIEEGYRTRDIAEDPEKAVSTSQMGDLICKKLEE 352 >UniRef50_Q9FMT1 3-isopropylmalate dehydrogenase 3, chloroplastic n=385 Tax=cellular organisms RepID=LEU33_ARATH Length = 409 Score = 357 bits (915), Expect = 6e-97, Method: Compositional matrix adjust. Identities = 189/363 (52%), Positives = 247/363 (68%), Gaps = 4/363 (1%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATV 62 K Y+IA+LPGDGIGPEV++ A VL + + VGGAA+D G PLP T Sbjct: 45 KRYNIALLPGDGIGPEVISVAKNVLQKAGSLEGLEFDFKEMPVGGAALDLVGVPLPEETF 104 Query: 63 EGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 + +DA+L G++GG KW+ +PE AL LR+ K+F+NLRPA + L Sbjct: 105 TAAKLSDAILLGAIGGYKWDKNEKHLRPEM-ALFYLRRDLKVFANLRPATVLPQLVDAST 163 Query: 123 LRADIAANGFDILCVRELTGGIYFGQPKGRE-GSGQYEKAFDTEVYHRFEIERIARIAFE 181 L+ ++A G D++ VRELTGGIYFG+P+G E TE+Y EI+RIAR+AFE Sbjct: 164 LKKEVA-EGVDMMIVRELTGGIYFGEPRGITINENGEEVGVSTEIYAAHEIDRIARVAFE 222 Query: 182 SARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFD 241 +ARKRR K+ S+DKANVL +SILWR+ V +A+EYPDVEL+HMY+DNA MQLI+DP QFD Sbjct: 223 TARKRRGKLCSVDKANVLDASILWRKRVTALASEYPDVELSHMYVDNAAMQLIRDPKQFD 282 Query: 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQ 301 ++ +N+FGDILSDE +MITGS+GMLPSASL E G GL+EP GSAPDIAG++ ANP+A Sbjct: 283 TIVTNNIFGDILSDEASMITGSIGMLPSASLGESGPGLFEPIHGSAPDIAGQDKANPLAT 342 Query: 302 ILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDL-ARGAAAVSTDEMGDIIARYVA 360 ILS A+LL+Y L + AA IE A+ AL +G RTGD+ + G V EMG+ + + V Sbjct: 343 ILSAAMLLKYGLGEEKAAKRIEDAVVDALNKGFRTGDIYSPGNKLVGCKEMGEEVLKSVE 402 Query: 361 EGV 363 V Sbjct: 403 SKV 405 >UniRef50_D1HRU7 3-isopropylmalate dehydrogenase (Fragment) n=2 Tax=Vitis vinifera RepID=D1HRU7_VITVI Length = 506 Score = 353 bits (906), Expect = 5e-96, Method: Compositional matrix adjust. Identities = 185/359 (51%), Positives = 247/359 (68%), Gaps = 4/359 (1%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATV 62 K Y I +LPGDGIGPEV++ A VL + + VGG A+D G PLP T+ Sbjct: 142 KRYSITLLPGDGIGPEVISVAKNVLKLAGSLEGIEFGFQEMPVGGCALDLTGVPLPEETL 201 Query: 63 EGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 +Q+DAVL G++GG KW+ +PE G LL LR K+F+NLRPA + L Sbjct: 202 LVAKQSDAVLLGAIGGYKWDSNEKHLKPETG-LLQLRSGLKVFANLRPASVLPQLVDAST 260 Query: 123 LRADIAANGFDILCVRELTGGIYFGQPKG-REGSGQYEKAFDTEVYHRFEIERIARIAFE 181 L+ ++A G D++ VRELTGGIYFG+P+G + E F+TEVY +EI+RIARIAFE Sbjct: 261 LKKEVA-EGVDLMVVRELTGGIYFGKPRGFSKNENGEEIGFNTEVYATYEIDRIARIAFE 319 Query: 182 SARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFD 241 +A+KRR K+ S+DKANVL++S+LWR+ V +A+EYPDVEL+HMY+DNA MQL+++P QFD Sbjct: 320 TAQKRRGKLCSVDKANVLEASMLWRKRVTAMASEYPDVELSHMYVDNAAMQLVRNPKQFD 379 Query: 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQ 301 ++ +N+FGDILSDE +MITGS+GMLPSAS+ E G GL+EP GSAPDIAG++ ANP+A Sbjct: 380 TIVTNNIFGDILSDEASMITGSIGMLPSASVGESGPGLFEPIHGSAPDIAGQDKANPLAT 439 Query: 302 ILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLAR-GAAAVSTDEMGDIIARYV 359 +LS A+LLRY L +AA IE A+ L+ G RT D+ G V EMG+ + + V Sbjct: 440 VLSAAMLLRYGLGEGNAAKRIETAVLDTLDRGFRTRDIYEAGTKLVGCKEMGEQVLKAV 498 >UniRef50_C9KJM9 3-isopropylmalate dehydrogenase n=1 Tax=Mitsuokella multacida DSM 20544 RepID=C9KJM9_9FIRM Length = 355 Score = 339 bits (870), Expect = 8e-92, Method: Compositional matrix adjust. Identities = 178/357 (49%), Positives = 246/357 (68%), Gaps = 4/357 (1%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 +Y I V+PGDGIG E+ A++VL+ V +F + ++ ++ D GG A D G PLP T+E Sbjct: 2 SYKITVIPGDGIGKEITDSAVEVLEKVDEKFGLGLSYTYKDAGGTAYDKFGTPLPDDTIE 61 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 C+ +D VLFG+VGG KW+++ P +PE+ A+L LRK+ L++NLRP K+ L + PL Sbjct: 62 ACKASDGVLFGAVGGDKWDNVDPALRPEK-AILGLRKNLGLYANLRPVKVADALVEYSPL 120 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 + ++ G D++ VREL GGIYFG E E+A+D E Y E++RIA++AFE+A Sbjct: 121 KPELV-KGVDLVIVRELIGGIYFGDKCESEQHNGAERAWDLENYSVPEVDRIAKLAFETA 179 Query: 184 RKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVL 243 + RR KVTS+DKANVL +S LWR V ++A YPDVEL ++Y+DN MQL P+QFDV+ Sbjct: 180 KLRRGKVTSVDKANVLATSRLWRRTVAKVAESYPDVELNNLYVDNCAMQLAIRPTQFDVI 239 Query: 244 LCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQIL 303 + NLFGDILSDE A++ GS+GM+PSAS+ LYEP GSAPDIAGK IANP+ IL Sbjct: 240 VTGNLFGDILSDEAAVVGGSIGMMPSASIGTS-TSLYEPIHGSAPDIAGKGIANPMGTIL 298 Query: 304 SLALLLRYSLDADDAACAIERAINRALEEGIRTGDLAR-GAAAVSTDEMGDIIARYV 359 S A+LLRYSL + AA AIE A+++AL +G RT DL + G +T+E+ +I + Sbjct: 299 SAAMLLRYSLHEEAAAKAIEAAVDKALADGYRTPDLWKEGFQKANTEEITKVICERI 355 >UniRef50_Q6GF15 3-isopropylmalate dehydrogenase n=94 Tax=Bacilli RepID=LEU3_STAAR Length = 348 Score = 333 bits (855), Expect = 5e-90, Method: Compositional matrix adjust. Identities = 166/353 (47%), Positives = 236/353 (66%), Gaps = 11/353 (3%) Query: 5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEG 64 Y+I LPGDGIGPE++ +L +L+ + N++ H++ GGA+ID G+PL T+ Sbjct: 3 YNIVALPGDGIGPEILNGSLSLLEIISNKYNFNYQIEHHEFGGASIDTFGEPLTEKTLNA 62 Query: 65 CEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 C++ADA+L G++GGPKW P+ +PE+G LL LRK LF+N+RP + +G + PL+ Sbjct: 63 CKRADAILLGAIGGPKWTD--PNNRPEQG-LLKLRKSLNLFANIRPTTVVKGASSLSPLK 119 Query: 125 ADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESAR 184 A+ G D++ VRELT GIYFG+P+ +A D+ Y R EIERI +AF+ A Sbjct: 120 AE-RVEGTDLVIVRELTSGIYFGEPRYFNN----HEALDSLTYTREEIERIVHVAFKLAA 174 Query: 185 KRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLL 244 RR K+TS+DK NVL SS LWR++VNE++ YP+V + H+ +D +M LI +P QFDV++ Sbjct: 175 SRRGKLTSVDKENVLASSKLWRKVVNEVSQLYPEVTVNHLLVDACSMHLITNPKQFDVIV 234 Query: 245 CSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILS 304 NLFGDILSDE ++I GS+G+ PSAS + G LYEP GSAPDIAGKN+ANP ILS Sbjct: 235 YENLFGDILSDEASVIPGSLGLSPSASFSNDGPRLYEPIHGSAPDIAGKNVANPFGMILS 294 Query: 305 LALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIAR 357 LA+ LR SL+ DAA +E+ I +E G T DL ++T ++ +I+++ Sbjct: 295 LAMCLRESLNQPDAADELEQHIYNMIEHGQTTADL---GGKLNTTDIFEILSQ 344 >UniRef50_Q5SIY4 3-isopropylmalate dehydrogenase n=53 Tax=cellular organisms RepID=LEU3_THET8 Length = 345 Score = 333 bits (853), Expect = 7e-90, Method: Compositional matrix adjust. Identities = 171/326 (52%), Positives = 227/326 (69%), Gaps = 7/326 (2%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCE 66 +AVLPGDGIGPEV ALKVL A+ + + + GGAAID G+P P T +G E Sbjct: 3 VAVLPGDGIGPEVTEAALKVLRALDEAEGLGLAYEVFPFGGAAIDAFGEPFPEPTRKGVE 62 Query: 67 QADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRAD 126 +A+AVL GSVGGPKW+ LP +PE G LL LRK LF+NLRPAK++ GLE PL+ + Sbjct: 63 EAEAVLLGSVGGPKWDGLPRKIRPETG-LLSLRKSQDLFANLRPAKVFPGLERLSPLKEE 121 Query: 127 IAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARKR 186 IA G D+L VRELTGGIYFG+P+G + +A++TE Y + E+ER+AR+AFE+ARKR Sbjct: 122 IA-RGVDVLIVRELTGGIYFGEPRGMSEA----EAWNTERYSKPEVERVARVAFEAARKR 176 Query: 187 RHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLLCS 246 R V S+DKANVL+ WR+ V E+ YPDV L H Y+D M L++ P++FDV++ Sbjct: 177 RKHVVSVDKANVLEVGEFWRKTVEEVGRGYPDVALEHQYVDAMAMHLVRSPARFDVVVTG 236 Query: 247 NLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLA 306 N+FGDILSD +++ GS+G+LPSASL +G ++EP GSAPDIAGK IANP A ILS A Sbjct: 237 NIFGDILSDLASVLPGSLGLLPSASLG-RGTPVFEPVHGSAPDIAGKGIANPTAAILSAA 295 Query: 307 LLLRYSLDADDAACAIERAINRALEE 332 ++L ++ + A +E A+ +AL E Sbjct: 296 MMLEHAFGLVELARKVEDAVAKALLE 321 >UniRef50_Q2VZV2 3-isopropylmalate dehydrogenase n=35 Tax=Bacteria RepID=LEU3_MAGSA Length = 369 Score = 332 bits (851), Expect = 1e-89, Method: Compositional matrix adjust. Identities = 184/360 (51%), Positives = 246/360 (68%), Gaps = 10/360 (2%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 + +LPGDGIG EVM Q +++D + + + + +GGAA D HG P P T+E Sbjct: 5 KLLILPGDGIGVEVMAQVRRIIDWMGRKRKIEFEITEGLLGGAAYDVHGTPYPAETLEAA 64 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 ADAVL G+VGGPKW+ LP D++PERG LL +RK LF+NLRPA + + L L+A Sbjct: 65 LAADAVLLGAVGGPKWDDLPFDKKPERG-LLGIRKDMGLFANLRPATVLEALADASTLKA 123 Query: 126 DIAANGFDILCVRELTGGIYFGQPKGREG-SGQYEKAFDTEVYHRFEIERIARIAFESAR 184 ++ + G DI+ +RELTGG+YFGQP+G + K ++T VY EI+RI R+AF+ AR Sbjct: 124 EVVS-GLDIMILRELTGGLYFGQPRGIDTLPDGTRKGYNTLVYTTPEIQRIGRVAFDLAR 182 Query: 185 KRRHKVTSIDKANVLQSSILWRE-IVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVL 243 KR K+ S+DKANVL+ ++LWRE ++ E+PDVEL HMY+DNA MQL+++P QFDV+ Sbjct: 183 KRNKKLCSVDKANVLECTVLWREEMIKLQKEEFPDVELTHMYVDNAAMQLVRNPKQFDVM 242 Query: 244 LCSNLFGDILSDECAMITGSMGMLPSASLNE---QG--FGLYEPAGGSAPDIAGKNIANP 298 + N+FGDILSD AM+TGS+GMLPSASL E QG LYEP GSAPDIAGK++ANP Sbjct: 243 VTENMFGDILSDCAAMLTGSLGMLPSASLGEADAQGKRKALYEPVHGSAPDIAGKDMANP 302 Query: 299 IAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLAR-GAAAVSTDEMGDIIAR 357 +A I+S A+ LRYS D A IE A+ L+ G+RT D+ + G A VST MG+ + R Sbjct: 303 LATIMSFAMCLRYSFDMAAEADLIETAVKNVLKGGLRTADIMQPGKAKVSTTVMGEAVVR 362 >UniRef50_Q2J3B4 3-isopropylmalate dehydrogenase n=132 Tax=Bacteria RepID=LEU3_RHOP2 Length = 370 Score = 328 bits (840), Expect = 3e-88, Method: Compositional matrix adjust. Identities = 173/364 (47%), Positives = 239/364 (65%), Gaps = 13/364 (3%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 + + +LPGDGIG EVM + +++D + T H VGGAA D + AT+ Sbjct: 3 THKLLLLPGDGIGTEVMAEVSRLIDWLNKAGIASFETEHGLVGGAAYDADKVAITDATMA 62 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 + +DAV+FG+VGGPKW+ +P D +PE G LL LRK LF+NLRPA Y L L Sbjct: 63 LAQASDAVIFGAVGGPKWDAVPYDARPEAG-LLRLRKDLALFANLRPAVCYPALAEASSL 121 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGRE--GSGQYEKAFDTEVYHRFEIERIARIAFE 181 + ++ G DI+ VRELTGG+YFG+PK G+GQ ++A DT+VY +EIERI R+AF+ Sbjct: 122 KPEV-VEGLDIMIVRELTGGVYFGEPKTITDLGNGQ-KRAIDTQVYDTYEIERIGRVAFD 179 Query: 182 SARKRRHKVTSIDKANVLQSSILWREIVNEI-ATEYPDVELAHMYIDNATMQLIKDPSQF 240 ARKRR+KVTS++K NV+++ +LW E++ ++ A EY DV+L H D+ M L+K P QF Sbjct: 180 LARKRRNKVTSMEKRNVMKTGVLWNEVITQVHAREYKDVQLEHQLADSGGMNLVKWPKQF 239 Query: 241 DVLLCSNLFGDILSDECAMITGSMGMLPSASLNE------QGFGLYEPAGGSAPDIAGKN 294 DV++ NLFGD+LSD AM+TGS+GMLPSASL + +YEP GSAPDIAGK Sbjct: 240 DVIVTDNLFGDMLSDIAAMLTGSLGMLPSASLGAVDDTTGKRKAMYEPVHGSAPDIAGKG 299 Query: 295 IANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDL-ARGAAAVSTDEMGD 353 +ANP+A + S + LRYSLD + A ++ AI L G+RT D+ + G+ VST +MG+ Sbjct: 300 LANPVAMLASFGMALRYSLDMGELADKLDEAIAVVLARGLRTADIKSEGSTVVSTSQMGE 359 Query: 354 IIAR 357 I + Sbjct: 360 AIVQ 363 >UniRef50_Q2K2V0 3-isopropylmalate dehydrogenase n=11 Tax=Alphaproteobacteria RepID=LEU3_RHIEC Length = 370 Score = 323 bits (827), Expect = 8e-87, Method: Compositional matrix adjust. Identities = 177/360 (49%), Positives = 235/360 (65%), Gaps = 13/360 (3%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 ++ +LPGDGIGPE M + K++ + T VGG A D HG + A ++ Sbjct: 5 NLFLLPGDGIGPEAMGEVRKIIAYMNEAMDAGFVTDEGLVGGCAYDAHGAAISEADMQKA 64 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 ADAVLFG+VGGPKW+ +P + +PE G LL LRK +LF+NLRPA Y L + L+ Sbjct: 65 LAADAVLFGAVGGPKWDSVPYEVRPEAG-LLRLRKDLQLFANLRPAICYPALASASSLKP 123 Query: 126 DIAANGFDILCVRELTGGIYFGQPKG--REGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 ++ G DIL +RELTGG+YFG+PK G+GQ ++ DT+VY +EIERIA +AFE A Sbjct: 124 EL-VEGLDILIIRELTGGVYFGEPKEIIDLGNGQ-KRGIDTQVYDTYEIERIAGVAFEMA 181 Query: 184 RKRRHKVTSIDKANVLQSSILWREIVNEI-ATEYPDVELAHMYIDNATMQLIKDPSQFDV 242 R R+++V S++K NV++S +LW ++V E +Y DV+L HM D MQL++ P QFDV Sbjct: 182 RTRQNRVCSMEKRNVMKSGVLWNQVVTETHKAKYSDVQLEHMLADAGGMQLVRQPKQFDV 241 Query: 243 LLCSNLFGDILSDECAMITGSMGMLPSASLNE------QGFGLYEPAGGSAPDIAGKNIA 296 ++ NLFGD+LSD AM+TGS+GMLPSASL + LYEP GSAPDIAGK IA Sbjct: 242 IVTDNLFGDMLSDVAAMLTGSLGMLPSASLGAPDGKTGKRKALYEPVHGSAPDIAGKGIA 301 Query: 297 NPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGD-LARGAAAVSTDEMGDII 355 NPIA I S A+ LRYS + A +E+AI L++GIRTGD +A G V T EMG+ I Sbjct: 302 NPIAMIASFAMCLRYSFNMVKEADDLEKAIANVLDKGIRTGDIMADGCRQVGTVEMGEAI 361 >UniRef50_Q2YL58 3-isopropylmalate dehydrogenase n=285 Tax=cellular organisms RepID=LEU3_BRUA2 Length = 370 Score = 322 bits (824), Expect = 2e-86, Method: Compositional matrix adjust. Identities = 183/365 (50%), Positives = 238/365 (65%), Gaps = 14/365 (3%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCE 66 + +LPGDGIGPE M + KV+ + + + T VGG A D HGQ + A +E Sbjct: 6 LLLLPGDGIGPEAMAEVRKVIAFLNSDLNLGFETEEGLVGGCAYDAHGQAISDADMEKAL 65 Query: 67 QADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRAD 126 AD+VLFG+VGGPKW+ +P + +PE G LL LRK +L++NLRPA Y L L+ + Sbjct: 66 AADSVLFGAVGGPKWDSVPYEVRPEAG-LLRLRKDMQLYANLRPAICYPALAHSSSLKPE 124 Query: 127 IAANGFDILCVRELTGGIYFGQPKG--REGSGQYEKAFDTEVYHRFEIERIARIAFESAR 184 + G DIL +RELTGG+YFG+PK G+GQ ++ DT+VY +EIERIA +AFE AR Sbjct: 125 V-IEGLDILILRELTGGVYFGEPKEIIDLGNGQ-KRGIDTQVYDTYEIERIADVAFELAR 182 Query: 185 KRRHKVTSIDKANVLQSSILWREIVNEIATE-YPDVELAHMYIDNATMQLIKDPSQFDVL 243 RR+KVTS++K NV++S +LW + V E + DV+L HM D MQL++ P QFDV+ Sbjct: 183 TRRNKVTSMEKRNVMKSGVLWNQGVTARHKEKHADVQLEHMLADAGGMQLVRWPKQFDVI 242 Query: 244 LCSNLFGDILSDECAMITGSMGMLPSASLNE------QGFGLYEPAGGSAPDIAGKNIAN 297 L NLFGD+LSD AM+TGS+GMLPSASL + LYEP GSAPDIAGK IAN Sbjct: 243 LTDNLFGDLLSDVAAMLTGSLGMLPSASLGAADSKTGKRKALYEPVHGSAPDIAGKGIAN 302 Query: 298 PIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDL-ARGAAAVSTDEMGD-II 355 PIA I SLA+ LRYS A +E AI L++GIRT D+ + G V T EMGD I+ Sbjct: 303 PIAMIASLAMCLRYSFGLVAEADRLEAAIAGVLDDGIRTADIWSEGNTKVGTTEMGDAIL 362 Query: 356 ARYVA 360 A++ A Sbjct: 363 AKFKA 367 >UniRef50_Q5HMF8 3-isopropylmalate dehydrogenase n=9 Tax=Bacilli RepID=LEU3_STAEQ Length = 347 Score = 319 bits (818), Expect = 8e-86, Method: Compositional matrix adjust. Identities = 159/336 (47%), Positives = 219/336 (65%), Gaps = 8/336 (2%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 +Y I LPGDGIGPE+++ L++L + ++ + GG +ID +G PL T++ Sbjct: 2 SYKIVALPGDGIGPEILSGTLELLKLISEKYHFEYHLESHHFGGVSIDYYGTPLTNETLQ 61 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 C+ ADA+L G++GGPKW P+ +PE G LL LRK LF+N+RP + +G PL Sbjct: 62 SCKNADAILLGAIGGPKWTD--PNNRPEHG-LLKLRKSLNLFANIRPTFVTKGASHLSPL 118 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 + DI G D++ VRELT GIYFG+P + + +A D+ Y EIERI RIAF A Sbjct: 119 KQDIV-EGTDLVIVRELTSGIYFGEPSYVKKT----EALDSLKYSSQEIERIVRIAFNLA 173 Query: 184 RKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVL 243 +RR K+TS+DK NVL SS LWR+IVN++ +YP+VE+ HM +D +M LI P+QFDV+ Sbjct: 174 NRRRKKLTSVDKENVLSSSKLWRQIVNDVKKDYPEVEVNHMLVDACSMHLITQPTQFDVI 233 Query: 244 LCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQIL 303 + NLFGDILSDE ++I GS+G+ PSAS + G LYEP GSAPDIA ++ ANP +L Sbjct: 234 VTENLFGDILSDEASVIPGSLGLSPSASFGQTGTRLYEPIHGSAPDIANEDKANPFGMVL 293 Query: 304 SLALLLRYSLDADDAACAIERAINRALEEGIRTGDL 339 SLAL LR SL+ +DAA +E + ++ T DL Sbjct: 294 SLALCLRESLNQNDAANELESIVYSFIQSNKTTADL 329 >UniRef50_Q4FP17 3-isopropylmalate dehydrogenase n=11 Tax=cellular organisms RepID=LEU3_PELUB Length = 368 Score = 312 bits (800), Expect = 1e-83, Method: Compositional matrix adjust. Identities = 177/361 (49%), Positives = 241/361 (66%), Gaps = 10/361 (2%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATV 62 K I +LPGDGIGPEV+ + KV+ + + ++ GG + D HG P+ Sbjct: 5 KKRKILLLPGDGIGPEVIQEVKKVILWLNSNKSLDFEIDEDLAGGCSYDKHGTPITDEVF 64 Query: 63 EGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 +++ V+ G+VGGPKW++L ++PER ALL LRK KLF+NLRPA ++ L Sbjct: 65 YKALESEFVMLGAVGGPKWDNLEFSKKPER-ALLKLRKELKLFANLRPAICFEQLVDAST 123 Query: 123 LRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYE-KAFDTEVYHRFEIERIARIAFE 181 L+ +I + G DI+ VRELTGGIYFG+P+G + E K +T Y EI R+A++AF+ Sbjct: 124 LKPEIVS-GLDIMIVRELTGGIYFGEPRGIKPIENGERKGINTHSYTTSEIVRVAKVAFD 182 Query: 182 SARKRRHKVTSIDKANVLQSSILWREIVNEIA-TEYPDVELAHMYIDNATMQLIKDPSQF 240 ARKR ++VTS +K+NV+++ LW+E V E+ EY DVEL+HM DN MQL+K+P QF Sbjct: 183 LARKRSNRVTSCEKSNVMEAGQLWKEEVQELHDKEYKDVELSHMLADNCAMQLLKNPKQF 242 Query: 241 DVLLCSNLFGDILSDECAMITGSMGMLPSASL---NEQG--FGLYEPAGGSAPDIAGKNI 295 DV++ NLFGD+LSD+ +M+TGS+G+LPSASL N+ G +YEP GSAPDIAGK I Sbjct: 243 DVIVTDNLFGDMLSDQASMLTGSLGLLPSASLGAKNKDGEMRAMYEPIHGSAPDIAGKEI 302 Query: 296 ANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGD-LARGAAAVSTDEMGDI 354 ANPIA ILS A+ LRYSLD D A A+E+A+ L +G+RT D L++G VST MGD Sbjct: 303 ANPIASILSFAMALRYSLDLDSEADALEKAVQDVLNDGLRTKDILSQGKKEVSTSAMGDA 362 Query: 355 I 355 I Sbjct: 363 I 363 >UniRef50_Q81G11 3-isopropylmalate dehydrogenase n=105 Tax=Bacteria RepID=LEU3_BACCR Length = 354 Score = 311 bits (797), Expect = 2e-83, Method: Compositional matrix adjust. Identities = 166/333 (49%), Positives = 212/333 (63%), Gaps = 10/333 (3%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCE 66 I L GDG+GPEVM A +VL V + GG AID GQPLP T+ C Sbjct: 5 IVCLAGDGVGPEVMESAKEVLHMVERLYGHHFHLQDEYFGGVAIDLTGQPLPQRTLAACL 64 Query: 67 QADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRAD 126 +DAVL G+VGGP+W+ ++PE+G LL LRK +F+N+RP + PL+ Sbjct: 65 ASDAVLLGAVGGPRWD--SAKERPEKG-LLALRKGLGVFANVRPVTVESATAHLSPLKN- 120 Query: 127 IAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARKR 186 A+ D + VRELTGGIYF PK R E A DT YHR EIERI AF+ A KR Sbjct: 121 --ADEIDFVVVRELTGGIYFSYPKER----TEEVATDTLTYHRHEIERIVSYAFQLANKR 174 Query: 187 RHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLLCS 246 + KVTSIDKANVL+SS LWR + E+A YP+VE+ H+ +D A M+LI++P +FDV++ Sbjct: 175 KKKVTSIDKANVLESSKLWRTVTEEVALRYPNVEVEHILVDAAAMELIRNPGRFDVIVTE 234 Query: 247 NLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLA 306 NLFGDILSDE +++ GS+GMLPSAS E+G LYEP GSAPDIAGKN ANPIA + S+A Sbjct: 235 NLFGDILSDEASVLAGSLGMLPSASHAEKGPSLYEPIHGSAPDIAGKNKANPIAMMRSVA 294 Query: 307 LLLRYSLDADDAACAIERAINRALEEGIRTGDL 339 ++L S AIE A++ L+ G T D+ Sbjct: 295 MMLGQSFGLTREGYAIEEAVSAVLKSGKCTADI 327 >UniRef50_Q2RV53 3-isopropylmalate dehydrogenase n=103 Tax=Bacteria RepID=LEU3_RHORT Length = 370 Score = 309 bits (791), Expect = 1e-82, Method: Compositional matrix adjust. Identities = 173/369 (46%), Positives = 237/369 (64%), Gaps = 10/369 (2%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPA 60 M + I L GDGIGPEVM Q +V+D + VGGAA D G PL Sbjct: 1 MPVSKKILFLAGDGIGPEVMAQVRRVMDWLNQTGRTAFEVEDALVGGAAYDAQGTPLHDD 60 Query: 61 TVEGCEQADAVLFGSVGGPKWE-HLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEA 119 TV ADAVL G+VGGPKW+ LP + +PERG LL LRK +LF+NLRPA ++ L Sbjct: 61 TVALALAADAVLLGAVGGPKWDASLPFELKPERG-LLRLRKDLELFANLRPAMVFDALAE 119 Query: 120 FCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEK-AFDTEVYHRFEIERIARI 178 L+ ++ + G D++ VRELTGG+YFGQP+G E+ +T+VY EI R+A++ Sbjct: 120 ASTLKTELVS-GLDVMIVRELTGGVYFGQPRGISALPNGERRGVNTQVYDTHEIVRVAKV 178 Query: 179 AFESARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPS 238 AF+ A KR ++ S++KANV++S +LWRE V ++ +YP++ L+HMY DN MQL++ P Sbjct: 179 AFDLAGKRGKRLCSVEKANVMESGLLWREEVTKLGADYPEIALSHMYADNCAMQLVRQPK 238 Query: 239 QFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGF-----GLYEPAGGSAPDIAGK 293 QFDV++ NLFGDILSD AM+TGS+GMLPSASL +YEP GSAPDIAG+ Sbjct: 239 QFDVIVTDNLFGDILSDCAAMLTGSLGMLPSASLGAADAAGNRRAMYEPVHGSAPDIAGQ 298 Query: 294 NIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLAR-GAAAVSTDEMG 352 + ANP+A ILS +++LRYS D + A ++ A+ L +G+RTGD+ + G V T MG Sbjct: 299 DKANPLATILSFSMMLRYSFDLAEEADLVDNAVRGVLAKGLRTGDIFQPGKTLVGTTGMG 358 Query: 353 DIIARYVAE 361 D + +A+ Sbjct: 359 DALLAEMAQ 367 >UniRef50_Q5LAB4 3-isopropylmalate dehydrogenase n=58 Tax=Bacteria RepID=LEU3_BACFN Length = 353 Score = 306 bits (785), Expect = 6e-82, Method: Compositional matrix adjust. Identities = 162/358 (45%), Positives = 230/358 (64%), Gaps = 11/358 (3%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 ++ IAVL GDGIGPE+ Q ++V+ AV +F ++ + G AID G P P T Sbjct: 2 DFKIAVLAGDGIGPEISVQGVEVMSAVCEKFGHKVNYEYAICGADAIDKVGDPFPEETYR 61 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQ-QPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 C+ ADAVLF +VG PK+++ P + +PE+G LL +RK LF+N+RP + ++ L P Sbjct: 62 VCKNADAVLFSAVGDPKFDNDPTAKVRPEQG-LLAMRKKLGLFANIRPVQTFKCLVHKSP 120 Query: 123 LRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFES 182 LRA++ G D LC+RELTGG+YFG E +KA+DT +Y R EIERI ++ FE Sbjct: 121 LRAELV-EGADFLCIRELTGGMYFG-----EKYQDNDKAYDTNMYTRPEIERILKVGFEY 174 Query: 183 ARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDV 242 A KRR +T +DKANVL SS LWR+I E+A +YP+V +M++DNA M++I++P FDV Sbjct: 175 AMKRRKHLTVVDKANVLASSRLWRQIAQEMAPQYPEVTTDYMFVDNAAMKMIQEPKFFDV 234 Query: 243 LLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQI 302 ++ N FGDIL+DE ++I+GSMG+LPSAS E ++EP GS P G NIANP+AQI Sbjct: 235 MVTENTFGDILTDEGSVISGSMGLLPSASTGEST-PVFEPIHGSWPQAKGLNIANPLAQI 293 Query: 303 LSLALLLRYSLDADDAACAIERAINRALEEGIRTGDL-ARGAAAVSTDEMGDIIARYV 359 LS+A+L Y D I +A++ +L+ +RT ++ G T E+G I Y+ Sbjct: 294 LSVAMLFEY-FDCKAEGALIRKAVDASLDANVRTPEIQVEGGEKFGTKEVGAWIVDYI 350 >UniRef50_Q1ARE1 3-isopropylmalate dehydrogenase n=2 Tax=Bacteria RepID=Q1ARE1_RUBXD Length = 355 Score = 306 bits (783), Expect = 1e-81, Method: Compositional matrix adjust. Identities = 171/340 (50%), Positives = 222/340 (65%), Gaps = 10/340 (2%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPA 60 MS+ + + +LPGDGIGPEV+ A +V DA RF + + +G AAI G P+ Sbjct: 1 MSQRFRVLLLPGDGIGPEVVAAARRVADAAAARFGLTLEYEERRIGAAAIREEGAPVSKE 60 Query: 61 TVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAF 120 T+ +ADAVL G+VG P+++ + +PE G LL LR+ F+NLRP L Sbjct: 61 TLRRAGEADAVLLGAVGDPEFDG--GEVRPEAG-LLALRRELGTFANLRPVAAIPALSGS 117 Query: 121 CPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAF 180 PLR +A G D+L VRELTGG YFG+ + E E+A D VY R E+ER+AR+AF Sbjct: 118 SPLRPGVA-EGVDLLIVRELTGGAYFGEKEEGE-----ERASDLSVYTRGEVERVARVAF 171 Query: 181 ESARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQF 240 E+AR RR +V S+DKANVL +S LWR +V E+A +YPDV L H+ +D A M L+ DP +F Sbjct: 172 EAARGRRGRVASVDKANVLATSRLWRRVVGEVARDYPDVALEHVLVDAAAMHLVTDPGRF 231 Query: 241 DVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGF-GLYEPAGGSAPDIAGKNIANPI 299 DV+L NLFGDILSDE A++ GSMGMLPSASL E G G++EP GSAPDIAGK +ANP Sbjct: 232 DVILTENLFGDILSDEAAVLPGSMGMLPSASLGEPGSPGIFEPVHGSAPDIAGKGVANPY 291 Query: 300 AQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDL 339 A ILS A++ R+ L +AA AIER + A+ G T DL Sbjct: 292 AAILSAAMMFRHGLGRPEAAEAIERGVEAAVAAGCLTPDL 331 >UniRef50_D0J9Z6 3-isopropylmalate dehydrogenase n=7 Tax=Bacteroidetes RepID=D0J9Z6_BLASP Length = 353 Score = 305 bits (780), Expect = 2e-81, Method: Compositional matrix adjust. Identities = 160/360 (44%), Positives = 237/360 (65%), Gaps = 11/360 (3%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPA 60 M KN I V+ GDGIGPEV+ QA+K L+++ NRF + + G AI+ G P+P Sbjct: 1 MKKN--IVVIEGDGIGPEVIKQAIKALNSIGNRFHHEFSYQNVLAGAKAIETFGDPMPKE 58 Query: 61 TVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAF 120 T++ C ++DAVLFGS+G PK++ P +PE G LL LRK L+ N+RP Y G+ Sbjct: 59 TIDSCLKSDAVLFGSIGDPKYDSYPRGMRPEDG-LLKLRKEMDLYCNIRPIVTYPGINK- 116 Query: 121 CPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAF 180 P++ + G + + RELTGGIYFG+ KGR +G+ +A+D VY EIERI ++F Sbjct: 117 SPIK-ERKLEGVNFVIYRELTGGIYFGK-KGRSKNGK--EAYDYCVYSEKEIERIGEMSF 172 Query: 181 ESARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQF 240 ++AR R K+T +DKANVL++S LWRE++ ++A +Y DV+L +YIDNA MQ++ +P +F Sbjct: 173 KAARSRNRKMTLVDKANVLETSRLWREVIQKMALDYSDVDLEFLYIDNAAMQILINPRKF 232 Query: 241 DVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIA 300 DV+L N+FGDILSDE +++T S+G+LPSAS+ + L+EP GS P GKNIANP+ Sbjct: 233 DVILTDNMFGDILSDEASILTSSLGLLPSASIGSKK-SLFEPIHGSYPQAKGKNIANPLG 291 Query: 301 QILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLA-RGAAAVSTDEMGDIIARYV 359 ILS++++L Y + +E A+ +++E I T D+ + ST+E+GD I +Y+ Sbjct: 292 CILSVSMMLEY-FEMPQEKNLLEEAVKSSIQEKICTPDIILDDRNSSSTEEVGDYIEKYI 350 >UniRef50_Q05FQ8 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Carsonella ruddii PV RepID=Q05FQ8_CARRP Length = 349 Score = 291 bits (744), Expect = 3e-77, Method: Compositional matrix adjust. Identities = 148/366 (40%), Positives = 224/366 (61%), Gaps = 27/366 (7%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDA-VRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEG 64 ++ +LPGDGIGPE++ Q +K++ + + + + I ++ +GG +ID P+ + Sbjct: 3 NLLILPGDGIGPEIIKQVIKIVKSCIYTGYKINIIYNY--IGGISIDKFNTPITNNLISI 60 Query: 65 CEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 + D + G VGG KW H +PE G LL LRK F F+N+RP K CP + Sbjct: 61 IKYIDTIFLGCVGGYKWNH--SIFKPEYG-LLKLRKKFNFFTNIRPIK--------CPFK 109 Query: 125 ADIAANGFDILCVRELTGGIYFGQPKG--REGSGQYEK--AFDTEVYHRFEIERIARIAF 180 DI+ VREL GGIY+G+PKG ++ Q A++T++Y+ EI R+ARI+F Sbjct: 110 ------NIDIIIVRELNGGIYYGKPKGFSKQIINQIPTWYAYNTKIYNEQEIIRLARISF 163 Query: 181 ESARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQF 240 A R+ K+ SIDK+NVL++ LW++ +N + Y V+L+H+YID AT+ LIK+ ++F Sbjct: 164 NLALNRKKKLCSIDKSNVLETFKLWKKTINYVHKFYNKVKLSHIYIDYATIDLIKNFNKF 223 Query: 241 DVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIA 300 DV++ SNLFGDI+SD C+++TGS+GMLPS S+N + L+EP GSAPDIA KNIANP+ Sbjct: 224 DVIITSNLFGDIISDLCSLLTGSLGMLPSISINNKSLSLFEPCHGSAPDIANKNIANPVG 283 Query: 301 QILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLA---RGAAAVSTDEMGDIIAR 357 +LSL ++ Y L+ + + +I + L G T D+ R VST+E GD++ Sbjct: 284 ALLSLVMMFEYVLNDFKLSNNLYYSIYKVLSYGFCTIDMKKYIRNFKIVSTEEFGDLVNH 343 Query: 358 YVAEGV 363 + V Sbjct: 344 FFIINV 349 >UniRef50_P04173 3-isopropylmalate dehydrogenase n=61 Tax=Fungi/Metazoa group RepID=LEU3_YEAST Length = 364 Score = 278 bits (711), Expect = 2e-73, Method: Compositional matrix adjust. Identities = 166/372 (44%), Positives = 232/372 (62%), Gaps = 22/372 (5%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRN-RFAMRITTSHYDVGGAAIDNHGQPLPP 59 MS I VLPGD +G E+ +A+KVL A+ + R ++ ++ +GGAAID G PLP Sbjct: 1 MSAPKKIVVLPGDHVGQEITAEAIKVLKAISDVRSNVKFDFENHLIGGAAIDATGVPLPD 60 Query: 60 ATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKL-YQGLE 118 +E ++ADAVL G+VGGPKW +PE+G LL +RK +L++NLRP L Sbjct: 61 EALEASKKADAVLLGAVGGPKWGT--GSVRPEQG-LLKIRKELQLYANLRPCNFASDSLL 117 Query: 119 AFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARI 178 P++ A G D + VREL GGIYFG+ K +G G A+D+E Y E++RI R+ Sbjct: 118 DLSPIKPQF-AKGTDFVVVRELVGGIYFGKRKEDDGDGV---AWDSEQYTVPEVQRITRM 173 Query: 179 AFESARKRRH--KVTSIDKANVLQSSILWREIVNE-IATEYPDVELAHMYIDNATMQLIK 235 A A + + S+DKANVL SS LWR+ V E I E+P +++ H ID+A M L+K Sbjct: 174 AAFMALQHEPPLPIWSLDKANVLASSRLWRKTVEETIKNEFPTLKVQHQLIDSAAMILVK 233 Query: 236 DPSQFD-VLLCSNLFGDILSDECAMITGSMGMLPSASL-----NEQGFGLYEPAGGSAPD 289 +P+ + +++ SN+FGDI+SDE ++I GS+G+LPSASL FGLYEP GSAPD Sbjct: 234 NPTHLNGIIITSNMFGDIISDEASVIPGSLGLLPSASLASLPDKNTAFGLYEPCHGSAPD 293 Query: 290 IAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTD 349 + KN NPIA ILS A++L+ SL+ + AIE A+ + L+ GIRTGDL + ST Sbjct: 294 LP-KNKVNPIATILSAAMMLKLSLNLPEEGKAIEDAVKKVLDAGIRTGDL---GGSNSTT 349 Query: 350 EMGDIIARYVAE 361 E+GD +A V + Sbjct: 350 EVGDAVAEEVKK 361 >UniRef50_Q12545 3-isopropylmalate dehydrogenase n=54 Tax=cellular organisms RepID=LEU3_CEPAC Length = 380 Score = 270 bits (691), Expect = 5e-71, Method: Compositional matrix adjust. Identities = 168/381 (44%), Positives = 228/381 (59%), Gaps = 40/381 (10%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAV---RNRFAMRITTSHYDVGGAAIDNHGQPL 57 M+ Y I VLPGD IGPE+M +A+KVL + R +TT VGG +ID HG P+ Sbjct: 1 MTTTYKILVLPGDHIGPEIMAEAIKVLTTIETHRPNLHFNLTTDL--VGGTSIDTHGVPI 58 Query: 58 PPATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAK-LYQG 116 + ++ + +DAVLFGS+GGP+W + P PE G LL LR+H F+NLRP + L Sbjct: 59 TQSVLDAAKASDAVLFGSIGGPEWAGVHP--TPESG-LLQLRQHLDAFANLRPCEFLVPS 115 Query: 117 LEAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIA 176 L P+R + G + VRE GG YFG+ K E + A D VY R EIER+A Sbjct: 116 LVGASPIREHVV-KGTRFIVVRENCGGAYFGEKKEEE-----DVASDLWVYTRPEIERLA 169 Query: 177 RIAFESAR--------KRRHKVTSIDKANVLQSSILWREIVNEI-ATEYPDVELAHMYID 227 R++ AR + V S DKANVL S LWR I ++I A E+PD+ L H D Sbjct: 170 RVSAAVARIMGRSEDDNQAATVWSADKANVLASGRLWRRITSDIFAKEFPDITLQHQLAD 229 Query: 228 NATMQLIKDPSQFD-VLLCSNLFGDILSDECAMITGSMGMLPSASL------NEQGFGLY 280 + M +++DP +F+ V+ N FGDILSD ITG++G++PSASL + G+Y Sbjct: 230 SMAMLMVRDPRRFNGVIHTDNTFGDILSDISGAITGTLGLMPSASLCGVPGEGHRSNGIY 289 Query: 281 EPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALE---EG---I 334 EP GSAPDI+GK +ANP+AQILS+A++LRYS+ + A A+ERA+ + L+ EG I Sbjct: 290 EPVHGSAPDISGKGLANPVAQILSVAMMLRYSMGLEKEATAVERAVVKVLDAKSEGGLEI 349 Query: 335 RTGDLARGAAAVSTDEMGDII 355 RTGDL G A S ++GD + Sbjct: 350 RTGDLG-GRATCS--QVGDAV 367 >UniRef50_O59930 3-isopropylmalate dehydrogenase n=12 Tax=cellular organisms RepID=LEU3_PHACH Length = 380 Score = 265 bits (676), Expect = 2e-69, Method: Compositional matrix adjust. Identities = 161/362 (44%), Positives = 219/362 (60%), Gaps = 26/362 (7%) Query: 1 MSK-NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFA-MRITTSHYDVGGAAIDNHGQPLP 58 MSK + I +LPGDGIGPEV+ +A +VL+ V + + I +D GG +ID HG+PL Sbjct: 1 MSKRTFKIVILPGDGIGPEVVAEATRVLEVVSASSSDVEIKLETHDFGGCSIDKHGEPLT 60 Query: 59 PATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQ-GL 117 AT+E C+ ADA+L G++GGPKW + +PE+ ALL LRK L++N+RPA L Sbjct: 61 AATLEACKLADAILLGAIGGPKW-GVNSKVRPEQ-ALLALRKALGLYANIRPANFASDSL 118 Query: 118 EAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIAR 177 A+ PL+ + A G DI+ +REL GG YFG+ K Q + A+DT +Y E++RI R Sbjct: 119 LAYSPLKPSV-ARGVDIIVIRELIGGAYFGERKELGARAQEDAAWDTMIYSVPEVQRITR 177 Query: 178 IAFESARKRRH-KVTSIDKANVLQSSILWREIVNE-IATEYPDVELAHMYIDNATMQLIK 235 + A V SIDKANVL SS LWR++ E I E+P ++L H +D+A+M ++ Sbjct: 178 SRRQVASPDPPLPVHSIDKANVLASSRLWRKVATETIQNEFPQLKLDHHLVDSASMLIVA 237 Query: 236 DPSQFD-VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFG------------LYEP 282 +P + + V+L NLFGDILSDE ++I GS+G+LPSASL + +YEP Sbjct: 238 NPKKLNGVILTENLFGDILSDESSVIPGSLGLLPSASLAARPLWPNTAHRRSSPRRVYEP 297 Query: 283 AGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRA-----LEEGIRTG 337 GSAPDIAG+ IANPI ILS A+L A AIE A+ A EG+RT Sbjct: 298 IHGSAPDIAGQGIANPIGTILSAAMLCGTRSVWRSPAKAIEAAVEGARRQGDRREGLRTA 357 Query: 338 DL 339 DL Sbjct: 358 DL 359 >UniRef50_A1SWV5 3-isopropylmalate dehydrogenase n=1 Tax=Psychromonas ingrahamii 37 RepID=A1SWV5_PSYIN Length = 368 Score = 264 bits (674), Expect = 4e-69, Method: Compositional matrix adjust. Identities = 155/365 (42%), Positives = 219/365 (60%), Gaps = 12/365 (3%) Query: 5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFA-MRITTSHYDVGGAAIDNHGQPLPPATVE 63 Y+IA+L GDGIGPEVM +A+KVL + R + + G AA G P T Sbjct: 4 YNIALLAGDGIGPEVMKEAVKVLKLIEQRNEDVNFELNDVLFGAAAYFAMGHAFPDETKA 63 Query: 64 GCEQADAVLFGSVG--GPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 C++ADA+L G++G + +P D+QPERGALLPLR+ + F+N RP L +GL F Sbjct: 64 ACDKADAILKGTIGLNHEDSKKIPIDEQPERGALLPLRRRYNTFANFRPVYLPKGLAHFS 123 Query: 122 PLRADIAANGFDILCVRELTGGIYFGQPK-GREGSGQYEKAFDTEV--YHRFEIERIARI 178 PL+A + G DI+ +REL GG+YFG+ + G G K F EV Y +I +I ++ Sbjct: 124 PLKASVIGEGIDIMIIRELVGGLYFGEKEMGVNADG---KRFVREVLEYDEDQIRQIVKV 180 Query: 179 AFESARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPS 238 FE + KR+ + +I K+NVL+SS+LW EIV E + YP+VE+ ++ +D A L +P Sbjct: 181 GFEVSMKRKKVMHNIHKSNVLKSSVLWNEIVEEESKNYPEVEVKNILVDAAATYLCLNPG 240 Query: 239 QFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANP 298 FDV++ N+FGDILSD+ I GS+G++PSA YEP+ GSAPDIAGK IANP Sbjct: 241 MFDVMVMENMFGDILSDQGGGILGSLGLMPSACKGPDK-SYYEPSHGSAPDIAGKGIANP 299 Query: 299 IAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAA--VSTDEMGDIIA 356 + I S+AL+L S + A + A+ E G T DL++ A VST E GD++ Sbjct: 300 YSMIGSVALMLEMSFGLEKEAKNLWAAMQAVFENGYSTSDLSKEGEANLVSTAEFGDLVC 359 Query: 357 RYVAE 361 +A+ Sbjct: 360 AELAK 364 >UniRef50_P34738 3-isopropylmalate dehydrogenase n=8 Tax=cellular organisms RepID=LEU3_NEUCR Length = 368 Score = 261 bits (668), Expect = 2e-68, Method: Compositional matrix adjust. Identities = 162/365 (44%), Positives = 225/365 (61%), Gaps = 22/365 (6%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRF--AMRITTSHYDVGGAAIDNHGQPLPPAT 61 ++I V GD GPEV+ +A+KVL A+ A + ++ +GGA+ID H PL Sbjct: 3 THNIVVFGGDHCGPEVVLEAIKVLKAIETNSPSAGKFNLQNHLLGGASIDKHNDPLTDEA 62 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKL-YQGLEAF 120 + + ADAVL G++GGP+W +PE+G LL LRK + NLRP + L Sbjct: 63 LNAAKAADAVLLGAIGGPEW-GTSSTVRPEQG-LLKLRKELGTYGNLRPCNFASESLVDS 120 Query: 121 CPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIA- 179 PL+A++ G D + VRELTGGIYFG +GSG A DTE Y R EI RIAR+A Sbjct: 121 SPLKAEVC-RGTDFIVVRELTGGIYFGDRTEDDGSGY---ACDTEPYSRAEIVRIARLAG 176 Query: 180 -FESARKRRHKVTSIDKANVLQSSILWREIVNE-IATEYPDVELAHMYIDNATMQLIKDP 237 A+ KV S+DKANVL +S LWR+ V + I+ E+P ++L H ID+A M L+K+P Sbjct: 177 FLALAKNPPAKVWSLDKANVLATSRLWRKTVTDVISKEFPQLQLEHQLIDSAAMLLVKNP 236 Query: 238 SQFD-VLLCSNLFGDILSDECAMITGSMGMLPSASL------NEQGFGLYEPAGGSAPDI 290 + V++ SNLFGDI+SDE ++I GS+G+LPSASL + G+YEP GSAPDI Sbjct: 237 RALNGVVITSNLFGDIISDEASVIPGSIGLLPSASLGGIPDGKGKCNGIYEPIHGSAPDI 296 Query: 291 AGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDE 350 +GK I NP+ ILS+A++LRYSL+ A A+E A+ A++ G +T DL A +T + Sbjct: 297 SGKGIVNPVGTILSVAMMLRYSLNLPKEADAVEAAVKAAIDNGTKTKDLGGNA---TTSD 353 Query: 351 MGDII 355 MG+ + Sbjct: 354 MGNAV 358 >UniRef50_D0DDG4 3-isopropylmalate dehydrogenase n=1 Tax=Citreicella sp. SE45 RepID=D0DDG4_9RHOB Length = 594 Score = 234 bits (598), Expect = 3e-60, Method: Compositional matrix adjust. Identities = 139/326 (42%), Positives = 194/326 (59%), Gaps = 19/326 (5%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAV-RNRFAMRITTSHYDVGGAAIDNHGQPLPPAT 61 K Y++A++PGDGIG +V A++VL A + RFA T+ + HG+ +P Sbjct: 2 KTYNLALIPGDGIGVDVTDAAMEVLGAAAKGRFAFDTTSFPWSC--EYYLEHGRMMPEDG 59 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 +E DA+ G+VG W PD G LLP+RK F ++N+RP +L G+E Sbjct: 60 IETLRGFDAIYLGAVG---WPATVPDSVSLHGLLLPIRKAFNQYANIRPHRLLAGVEG-- 114 Query: 122 PLRADIAANGFDILCVRELTGGIYFGQPKGR--EGSGQYEKAFDTEVYHRFEIERIARIA 179 PL+A+ GFDILC+RE T G Y G GR EG G E A +T V+ R +ERI R Sbjct: 115 PLKAE----GFDILCIRENTEGEYSGA-GGRVHEGKGN-EVAVETSVFTRAGVERILRFG 168 Query: 180 FESARKRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPS 238 FE AR RR +TS+ K+N + S + W E+ E+A EYPDV ++HM+ID +++ P Sbjct: 169 FEQARSRRGHLTSVTKSNAQKYSMVFWDEVTRELAAEYPDVTVSHMHIDAMAAKMVMAPQ 228 Query: 239 QFDVLLCSNLFGDILSDECAMITGSMGMLPSASLN--EQGFGLYEPAGGSAPDIAGKNIA 296 DV++ SNLFGDIL+D A I G +G SA++N ++EP GSAPDIAGKNIA Sbjct: 229 DLDVVVASNLFGDILTDLGAAIQGGLGFAASANINPDRSAPSMFEPVHGSAPDIAGKNIA 288 Query: 297 NPIAQILSLALLLRYSLDADDAACAI 322 NPIA I S+A +L + +A+ +A + Sbjct: 289 NPIAAIWSVAQMLDHLGEAEVSAAVL 314 >UniRef50_B8M3W0 3-isopropylmalate dehydrogenase n=6 Tax=Leotiomyceta RepID=B8M3W0_TALSN Length = 378 Score = 234 bits (597), Expect = 3e-60, Method: Compositional matrix adjust. Identities = 155/382 (40%), Positives = 215/382 (56%), Gaps = 43/382 (11%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFA-MRITTSHYDVGGAAIDNHGQPLPP 59 M++ + VLPGD IGPE++ +ALK+L + ++ S+ +GGA++D G + Sbjct: 1 MAEIRKLLVLPGDHIGPEIIAEALKILAVLEEELPNFKVQISYGLIGGASLDKTGSAITD 60 Query: 60 ATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLY-QGLE 118 +E +DAVL GSVGGP+W H+P PE+G +L LR+ F+N+RP + Y L Sbjct: 61 EVLETAVASDAVLLGSVGGPEWAHVPGALSPEKG-ILHLRQRLDAFANIRPCRFYASSLL 119 Query: 119 AFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARI 178 PL+ +IAA G D + VRE GG YFG + F+ E R E+ER AR+ Sbjct: 120 NQSPLKPEIAA-GVDFVLVRENCGGAYFGT----------KTEFEDEA--RTEVERCARV 166 Query: 179 AFESAR----------KRRHKVTSIDKANVLQSSILWREIVNEI-ATEYPDVELAHMYID 227 + AR K V + DKANVL S WR + ++I E+PD+EL D Sbjct: 167 SAALARTFGRGKNTDDKSPAIVWNADKANVLASGRFWRTVTHDIFEREFPDIELHDQLAD 226 Query: 228 NATMQLIKDPSQFD-VLLCSNLFGDILSDECAMITGSMGMLPSASL-----NEQGF-GLY 280 + M ++K P++F+ V+ N FGDILSD I GS+G+LPSAS+ +E+ G+Y Sbjct: 227 SMAMVMVKAPTKFNGVIHTDNTFGDILSDISGGIVGSLGVLPSASVCGVPGSEKPVKGIY 286 Query: 281 EPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEE------GI 334 E GSAPDI+G ANPIAQILSLA+LLRYS A +E A+ + LE GI Sbjct: 287 EAVHGSAPDISGTGQANPIAQILSLAMLLRYSFSMPRQADLLEDAVRKTLEVREHGGLGI 346 Query: 335 RTGDLARGAAAVSTDEMGDIIA 356 RT DL A ST ++GD +A Sbjct: 347 RTKDLGGSA---STQDVGDAVA 365 >UniRef50_B1I496 3-isopropylmalate dehydrogenase n=4 Tax=Bacteria RepID=B1I496_DESAP Length = 364 Score = 233 bits (594), Expect = 8e-60, Method: Compositional matrix adjust. Identities = 140/368 (38%), Positives = 199/368 (54%), Gaps = 25/368 (6%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPA 60 M K Y IAV+PGDG GPE + + LKVL A + + T+ D GG G+ LPP Sbjct: 13 MQKTYKIAVIPGDGTGPEQVREGLKVLHAAAGKEGFALETTVLDWGGEYYLRTGEVLPPD 72 Query: 61 TVEGCEQADAVLFGSVGGPKWEHLPPDQQP---ERGALLPLRKHFKLFSNLRPAKLYQGL 117 VE ++ DA+ G++G P+ +P E+G LL LR + NLRP KLY G+ Sbjct: 73 AVEQLKRYDAIYLGAIG-------HPEVRPGILEKGILLRLRFELDQYINLRPVKLYPGV 125 Query: 118 EAFCPLRADIAANG---FDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIER 174 E IA G D + VRE T G+Y G + E A T + R +ER Sbjct: 126 ET------PIAGKGPEDIDFVVVRENTEGLYAGSGGFLKRGTPDEVAIQTSINTRKGVER 179 Query: 175 IARIAFESARKR--RHKVTSIDKANVLQSSI-LWREIVNEIATEYPDVELAHMYIDNATM 231 R AFE RKR R KVT K NVL + LW + NE+ EYPD+E + ++D M Sbjct: 180 CVRFAFEYCRKRGGRRKVTLCGKTNVLTFAFDLWERVFNEVGEEYPDIERDYAHVDAICM 239 Query: 232 QLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIA 291 ++K+P FDV++ N+FGDI++D AM+ G MG+ +LN +G ++EP GGSAP Sbjct: 240 WMVKNPEWFDVIVTDNMFGDIITDLGAMLQGGMGIAAGGNLNPEGVSMFEPIGGSAPKYT 299 Query: 292 GKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEM 351 GKN+ NP+A + + A++L L AA IE A+ + +++ LA G TDE+ Sbjct: 300 GKNVINPLAAVCAGAMMLE-QLGETGAAARIEEAVKKVCAGHLKS--LAAGRMGYGTDEV 356 Query: 352 GDIIARYV 359 GD++ ++ Sbjct: 357 GDLVVSHL 364 >UniRef50_B2J8P1 3-isopropylmalate dehydrogenase n=3 Tax=Cyanobacteria RepID=B2J8P1_NOSP7 Length = 363 Score = 232 bits (591), Expect = 2e-59, Method: Compositional matrix adjust. Identities = 140/336 (41%), Positives = 186/336 (55%), Gaps = 18/336 (5%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 +Y I +PG+GIGPEV+ +LK+L V + + +G A + G P AT E Sbjct: 8 SYRIVAIPGEGIGPEVVEASLKILQHVAKIQGFTLQVDYGWLGATAFEQLGSYFPQATTE 67 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 C+ AD ++FG+V +G LL LRKHF F NLRP + L L Sbjct: 68 LCDGADGIVFGAV--------------SQGGLLELRKHFDFFCNLRPIRSVNSLLHKSSL 113 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 R + G DIL VREL GIYFG P GR + + T Y+ EI RIAR A E A Sbjct: 114 RPE-KIQGLDILIVRELVSGIYFG-PSGRSSDERGNYGYHTMRYYDEEIRRIARKALEQA 171 Query: 184 RKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVL 243 + RR +T K N L + W +V E AT++P+V + M +DN MQ++ +P +FDV+ Sbjct: 172 QYRRGLLTVAHKENAL-PHLHWTRLVQEEATKFPNVIVEPMLVDNLAMQMVLNPQRFDVI 230 Query: 244 LCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQIL 303 L SNLFGDILSD + GS+G+L SASLN GFGLYE G+APDIAG IANP+ + Sbjct: 231 LASNLFGDILSDIGGALVGSIGLLGSASLNANGFGLYEAIHGTAPDIAGLGIANPLGTLG 290 Query: 304 SLALLLRYSLDADDAACAIERAINRALEEGIRTGDL 339 + L+L+ + A A +R L +G RT DL Sbjct: 291 ACVLMLQQWGEVQAAQQI-IAAQDRILAKGYRTADL 325 >UniRef50_Q4P2R4 3-isopropylmalate dehydrogenase n=1 Tax=Ustilago maydis RepID=Q4P2R4_USTMA Length = 363 Score = 229 bits (584), Expect = 1e-58, Method: Compositional matrix adjust. Identities = 140/372 (37%), Positives = 211/372 (56%), Gaps = 35/372 (9%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATV 62 K + + VL GD IGPEVM + L + D +++ F +++ T +GG+ +D H P+ +T+ Sbjct: 11 KAFKVMVLQGDHIGPEVMAEVLPLFDVIQSHFGIKVETFERLIGGSCLDQHDCPIQESTL 70 Query: 63 EGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 + + AVL GSVGGPKW+ ++PE G +L +RKH L++N+RPAK+ + Sbjct: 71 QEASECHAVLLGSVGGPKWDVGDSSRRPETG-ILRMRKHLNLYANVRPAKIISERQLELS 129 Query: 123 LRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFES 182 + G +I+ +RE GGIYFG+ K + H+ A ++ S Sbjct: 130 SLKEHVVRGVNIITLRENAGGIYFGR-----------KQEPDPLAHK------AALSLAS 172 Query: 183 ARKRRHKVTSIDKANVLQSSILWREIVNE-IATEYPDV--ELAHMYIDNATMQLIKDPSQ 239 + + S+DKANV+ +S LWR++V E I E+P + +L+H +D+A M L KDP + Sbjct: 173 SHGPL-PIISVDKANVMATSRLWRQVVTETIRDEFPQLMDKLSHQLVDSAAMLLAKDPRK 231 Query: 240 FD-VLLCSNLFGDILSDECAMITGSMGMLPSASLN-----EQGF----GLYEPAGGSAPD 289 + V+L NLFGDILSD ++I GS+G+L SA ++ Q F G+Y+P GSAPD Sbjct: 232 LNGVVLTENLFGDILSDLTSVIPGSLGVLGSAEIDGPPIPSQDFRMPMGVYQPVSGSAPD 291 Query: 290 IAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTD 349 IAGK IANPI +S L+ R+SL AA AI+ AI LE G T D+ +ST Sbjct: 292 IAGKGIANPIGMFMSFGLMCRWSLGLPKAADAIDSAIKDCLESGQCTRDV---GGTLSTQ 348 Query: 350 EMGDIIARYVAE 361 + G + + + E Sbjct: 349 QAGSALRQSIQE 360 >UniRef50_Q6W109 Tartrate dehydrogenase n=13 Tax=Bacteria RepID=Q6W109_RHISN Length = 347 Score = 228 bits (580), Expect = 3e-58, Method: Compositional matrix adjust. Identities = 139/338 (41%), Positives = 191/338 (56%), Gaps = 15/338 (4%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATV 62 K+Y IA++PGDGIG +V A +VL V +T + + A G +PP + Sbjct: 2 KSYSIALIPGDGIGQDVTDAAWQVLSTVARHSGFTLTATPFPWSCAFYKETGAMMPPDGI 61 Query: 63 EGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 E + DA+L G+VG W PD G LLP+RK F ++N+RP +L G++ P Sbjct: 62 ETLRRFDAILLGAVG---WPAEVPDSVSLHGLLLPIRKAFVQYANIRPHRLLSGVKG--P 116 Query: 123 LRADIAANGFDILCVRELTGGIYFGQPKGREGSGQY-EKAFDTEVYHRFEIERIARIAFE 181 L+A+ GFDILC+RE T G Y G GR G E A +T ++ R +ERI R F+ Sbjct: 117 LKAE----GFDILCIRENTEGEYSGA-GGRVHQGTADEVAVETSIFTRTGVERILRFGFD 171 Query: 182 SARKRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQF 240 AR+RR K+ S+ K+N + S +LW EI E+A EYPDVE+ +ID +++ P Sbjct: 172 QARQRRRKLASVTKSNAQKYSMVLWDEITRELAAEYPDVEVTSYHIDAMAARMVMAPESL 231 Query: 241 DVLLCSNLFGDILSDECAMITGSMGMLPSASLN--EQGFGLYEPAGGSAPDIAGKNIANP 298 DV++ SNLFGDIL+D A I G +G SA++N ++EP GSAPDIA IANP Sbjct: 232 DVVVASNLFGDILTDLGAAIQGGLGFAASANINPDRSAPSMFEPVHGSAPDIAHLGIANP 291 Query: 299 IAQILSLALLLRYSLDADDAACAIERAINRALEEGIRT 336 IA I S A++L + A A IE A+ R GI T Sbjct: 292 IAAIWSGAMMLDHLGQARAARKVIE-ALERTTARGIGT 328 >UniRef50_C5EHC0 3-isopropylmalate dehydrogenase n=1 Tax=Clostridiales bacterium 1_7_47FAA RepID=C5EHC0_9FIRM Length = 369 Score = 225 bits (573), Expect = 2e-57, Method: Compositional matrix adjust. Identities = 123/335 (36%), Positives = 193/335 (57%), Gaps = 4/335 (1%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPAT 61 S+ Y IA++PGDG+GPE+ +A+ L + + G AA+D PLP + Sbjct: 11 SRIYTIALIPGDGVGPEITREAVLTLKRAGEVYGRSFQFTEAIAGTAALDRGQCPLPRES 70 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 ++ C +AD++L G + + L +++PE L LR L S++RP + L C Sbjct: 71 LKTCLEADSILMGKLAVGRHPGLKFEERPE-SILGLLRTGLCLRSDIRPCFFAEALRELC 129 Query: 122 PLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFE 181 PL+ +I G DIL +R++ GG++ + K A+DTE Y I AR+AF+ Sbjct: 130 PLKEEIRKKGMDILIIRDIAGGMFTTEGKS-SNLCNVRAAWDTESYDETLIRDSARLAFQ 188 Query: 182 SARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFD 241 A R+ KVTS+DKA +L SS+LWR+I+ E +YP++EL HM +D+ +L+ P FD Sbjct: 189 LAASRKRKVTSLDKAILLSSSVLWRQILEETHRDYPEIELEHMLVDHGAFKLVSSPDAFD 248 Query: 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEP--AGGSAPDIAGKNIANPI 299 V++ SN+FGDI++DE A +TG+ LP+ SLN + G+Y P ++AG ANP+ Sbjct: 249 VIVASNVFGDIIADEAAGLTGAGEFLPAGSLNAERKGIYCPNQLHQVHEELAGTGRANPV 308 Query: 300 AQILSLALLLRYSLDADDAACAIERAINRALEEGI 334 IL+ A++L YS A ++RA++ +E+GI Sbjct: 309 GMILAAAMMLEYSFGLVREAEGMKRAVSIVMEQGI 343 >UniRef50_O29627 3-isopropylmalate dehydrogenase n=91 Tax=cellular organisms RepID=LEU3_ARCFU Length = 326 Score = 221 bits (563), Expect = 4e-56, Method: Compositional matrix adjust. Identities = 130/336 (38%), Positives = 199/336 (59%), Gaps = 32/336 (9%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 I V+PGDGIG EVM A+ +L+ + + S+YD G A++ +G+ LP T+E C Sbjct: 3 KIVVIPGDGIGKEVMEAAMLILE----KLDLPFEYSYYDAGDEALEKYGKALPDETLEAC 58 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 ++DAVLFG+ G + ++ LR+ F+N+RPAK +G+E P Sbjct: 59 RKSDAVLFGAAG-----------ETAADVIVRLRRELGTFANVRPAKAIEGIECLYP--- 104 Query: 126 DIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARK 185 G DI+ VRE T +Y G G G +A V R ERIAR AFE A++ Sbjct: 105 -----GLDIVVVRENTECLYMGF---EFGFGDVTEAI--RVITREASERIARYAFELAKR 154 Query: 186 R-RHKVTSIDKANVLQSSI-LWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVL 243 R KVT++ KANV++ + L+R++ E+A +YP+++ YID A M L+ DP +FDV+ Sbjct: 155 EGRKKVTALHKANVMKKTCGLFRDVCREVAKDYPEIQYNDYYIDAACMYLVMDPFRFDVI 214 Query: 244 LCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQIL 303 + +N+FGDI+SD A + G +G+ PSA++ E+ ++EP G+A DIAGK IANP A IL Sbjct: 215 VTTNMFGDIVSDLAAGLVGGLGLAPSANVGERT-AIFEPVHGAAFDIAGKGIANPTAMIL 273 Query: 304 SLALLLRYSLDADDAACAIERAINRALEEGIRTGDL 339 + ++LR+ ++A +E A+ + ++EG +T DL Sbjct: 274 TACMMLRHFGYVEEAK-KVEEAVEKTIKEGKKTPDL 308 >UniRef50_A3P147 Tartrate dehydrogenase n=59 Tax=Bacteria RepID=A3P147_BURP0 Length = 396 Score = 220 bits (561), Expect = 6e-56, Method: Compositional matrix adjust. Identities = 147/367 (40%), Positives = 203/367 (55%), Gaps = 21/367 (5%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAID---NHGQPLPP 59 K Y IAV+PGDGIG EVM + L+ LDAV RF +R ++ + A+ D HGQ +P Sbjct: 39 KVYRIAVIPGDGIGVEVMPEGLRALDAVSRRFGLRF--AYEPIEWASCDYYAKHGQMMPD 96 Query: 60 ATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEA 119 DA+LFG+VG W PD G+L+ R+ F + NLRPA+L+ G+ Sbjct: 97 DWKTQLSGMDALLFGAVG---WPETVPDHISLWGSLIKFRREFDQYVNLRPARLFDGVP- 152 Query: 120 FCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIA 179 CPL A A D + VRE T G Y + E V+ R ER+ + A Sbjct: 153 -CPL-AGRKAGDIDFMIVRENTEGEYSAVGGTMFEGTEREFVVQQAVFTRHGTERVLKFA 210 Query: 180 FESARKRRHKVTSIDKANVLQSSILWREI-VNEIATEYPDVELAHMYIDNATMQLIKDPS 238 FE A++R ++T K+N + S+ W + E+A YPDV +ID + + P Sbjct: 211 FELAQRRAKRLTVATKSNGIAISMPWWDARAAEMAARYPDVAWDKQHIDILCARFVMQPD 270 Query: 239 QFDVLLCSNLFGDILSDECAMITGSMGMLPSASLN-EQGF-GLYEPAGGSAPDIAGKNIA 296 +FDV++ SNLFGDILSD TG++G+ PSA+LN E+ F L+EP GSAPDIAGK+IA Sbjct: 271 RFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERNFPSLFEPVHGSAPDIAGKHIA 330 Query: 297 NPIAQILSLALLLRY----SLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMG 352 NPIA I S A+++ + + A +A AI AI L+ G RT D+ A ST E+G Sbjct: 331 NPIAMIWSAAMMVDFLGAGTGPAREAHDAIVAAIEHVLKHGPRTRDMGGRA---STREVG 387 Query: 353 DIIARYV 359 D I ++ Sbjct: 388 DAIVAHL 394 >UniRef50_A4IK21 Tartrate dehydrogenase n=7 Tax=Bacillaceae RepID=A4IK21_GEOTN Length = 357 Score = 215 bits (548), Expect = 2e-54, Method: Compositional matrix adjust. Identities = 142/368 (38%), Positives = 208/368 (56%), Gaps = 24/368 (6%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNR-FAMRITTSHYDVGGAAIDNHGQPLPPAT 61 + + IAVLPGDGIGPEVM +ALKVL ++++ + + + HG+ +P Sbjct: 2 REFRIAVLPGDGIGPEVMNEALKVLRILKDKDYTFQFHADMFLWNSEYYLQHGRMMPENG 61 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGL-EAF 120 ++ + DA+LFG++G P+ PD ++P+RK F + NLRP K +G+ E F Sbjct: 62 LDILKNYDAILFGAIGDPR----VPDDISVWELIMPIRKRFCQYVNLRPVKKLKGIPEQF 117 Query: 121 CPLRADIAANGFDILCVRELTGGIYFGQPKGR--EGSGQYEKAFDTEVYHRFEIERIARI 178 I + + VRE G Y GR +G+ Q E A + R ERIAR Sbjct: 118 IHQERPI-----NFVIVRENAEGEY-SNSGGRIYQGTDQ-EIAVQNTIITRKGTERIARY 170 Query: 179 AFESARKRRH-KVTSIDKAN-VLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKD 236 AF+ A+K + KV + K+N V+ S LW E++ +A+EYPD++L YID ++ Sbjct: 171 AFQYAKKHGYQKVINATKSNAVVHSMKLWDEVIEHVASEYPDIQLEKYYIDALAAYFVQR 230 Query: 237 PSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGF--GLYEPAGGSAPDIAGKN 294 P V++ SNLFGDILSD + + G +G+ PSA++N +G ++EP GSAPDIAGK Sbjct: 231 PDTLQVIVASNLFGDILSDLGSALVGGLGISPSANINPEGVFPSMFEPVHGSAPDIAGKG 290 Query: 295 IANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIR-TGDLARGAAAVSTDEMGD 353 ANPIAQI S AL+L+ SL +D A I +AI + E G + T DL + +T EMG+ Sbjct: 291 KANPIAQIWSAALMLQ-SLGREDLASIILKAIEKVTEHGEKLTEDLGGNS---TTAEMGE 346 Query: 354 IIARYVAE 361 I R + + Sbjct: 347 EIVRQIVK 354 >UniRef50_Q2JYV7 Probable tartrate dehydrogenase protein n=7 Tax=Rhizobium etli RepID=Q2JYV7_RHIEC Length = 347 Score = 214 bits (544), Expect = 5e-54, Method: Compositional matrix adjust. Identities = 130/335 (38%), Positives = 179/335 (53%), Gaps = 13/335 (3%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATV 62 K Y IA+LPGDGIG +V A VL+ + + Y +G +P + Sbjct: 2 KTYRIALLPGDGIGRDVTDAAWAVLEKTAGSGGFSLEATRYPWSCDYYLENGSMMPADGI 61 Query: 63 EGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 E + DA+L G+VG W PD G LLP+RK F ++N+RP +L G++ P Sbjct: 62 ETLKSFDAILLGAVG---WPRKVPDSVSLHGLLLPIRKAFVQYANIRPHRLLPGVQG--P 116 Query: 123 LRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFES 182 LR+D GFDILC+RE T G Y G E A +T ++ R +ERI R FE Sbjct: 117 LRSD----GFDILCIRENTEGEYSGAGGRIHQGADNEVAIETAIFTRKGVERILRFGFEQ 172 Query: 183 ARKRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFD 241 AR RR K+ S+ K+N + S + W EI + ++ EYPDVE+ +ID +++ P D Sbjct: 173 ARARRGKLASVTKSNAQKYSMVFWDEITHGLSAEYPDVEVTSYHIDAMAARMVMAPESLD 232 Query: 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLN--EQGFGLYEPAGGSAPDIAGKNIANPI 299 V+ SNLFGDIL+D A I G +G SA++N ++EP GSAPDIA IANPI Sbjct: 233 VVAASNLFGDILTDLGAAIQGGLGFAASANINPDRSAPSMFEPVHGSAPDIAHLGIANPI 292 Query: 300 AQILSLALLLRYSLDADDAACAIERAINRALEEGI 334 A I S A++L + L AA + AI G+ Sbjct: 293 AAIWSGAMMLEH-LGETAAAEKVMDAIETTTARGV 326 >UniRef50_Q47SB4 3-isopropylmalate dehydrogenase n=15 Tax=cellular organisms RepID=LEU3_THEFY Length = 354 Score = 213 bits (541), Expect = 1e-53, Method: Compositional matrix adjust. Identities = 147/364 (40%), Positives = 211/364 (57%), Gaps = 18/364 (4%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPAT 61 ++ +AV+PGDGIGPEV+ + LKVL AV R + + T+ Y++G G+ LP A Sbjct: 3 ARTVKLAVIPGDGIGPEVVAEGLKVLSAVAPRHGLTLDTTEYELGAQRWHATGEVLPDAV 62 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 E Q DA+L G+VG P P ERG LL LR +F + NLRP +LY G+ Sbjct: 63 EEELRQHDAILLGAVGDPTV----PSGVLERGLLLRLRFNFSHYVNLRPVRLYPGVT--T 116 Query: 122 PLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFE 181 PL A +A D+L VRE T G Y G +E A V R +ER+ R AF Sbjct: 117 PL-AGVAPEDIDMLVVREGTEGPYAGMGGVLRKGTPHEIATQDSVNTRLGVERVVRYAFA 175 Query: 182 SARKRR-HKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQ 239 A +R HK+T + K NVL + LW+ +V E+ EYP VE+ ++++D ATM + P + Sbjct: 176 KAAERPCHKLTLVHKDNVLTYAGELWQRVVREVGAEYPQVEVDYLHVDAATMFFVTQPRR 235 Query: 240 FDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGF--GLYEPAGGSAPDIAGKNIAN 297 FDV++ NLFGDI++D A + G +G+ S ++N +G ++EP GSAPDIAG+ A+ Sbjct: 236 FDVVVTDNLFGDIITDLGAAVAGGIGLAASGNINPEGDFPSMFEPVHGSAPDIAGQGKAD 295 Query: 298 PIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIAR 357 P A ILS++L+L + L DAA I++A+ L+E + G + ST ++GD IA+ Sbjct: 296 PTATILSVSLMLEH-LGYADAAAQIDQAVAEDLQERAKNGGVR------STTQIGDDIAQ 348 Query: 358 YVAE 361 VAE Sbjct: 349 RVAE 352 >UniRef50_O27441 3-isopropylmalate dehydrogenase n=30 Tax=Archaea RepID=LEU3_METTH Length = 329 Score = 212 bits (539), Expect = 2e-53, Method: Compositional matrix adjust. Identities = 136/359 (37%), Positives = 194/359 (54%), Gaps = 35/359 (9%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATV 62 K+ IAV+PGDGIG EVM AL +L N + + H D G A + G LP T+ Sbjct: 2 KSMKIAVIPGDGIGVEVMEAALHIL----NTLDLDLEFIHADAGDACLKRTGTALPEETL 57 Query: 63 EGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 E +A A LFG+ G + ++ LR+ F LF+NLRP K G+ P Sbjct: 58 EAVGEARATLFGAAG-----------ESAADVIVRLRREFDLFANLRPVKSLPGVPCLYP 106 Query: 123 LRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFES 182 D + VRE T +Y G + E A + R RI++ AF+ Sbjct: 107 --------DLDFVIVRENTEDLYVGDEEYTP-----EGAVAKRIITRTASRRISQFAFQY 153 Query: 183 ARKR-RHKVTSIDKANVLQSSI-LWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQF 240 A+K KVT++ KANVL+ + ++R+ ++A+EYP +E Y+D M LI P +F Sbjct: 154 AQKEGMQKVTAVHKANVLKKTDGIFRDEFYKVASEYPQMEATDYYVDATAMYLITQPQEF 213 Query: 241 DVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIA 300 ++ +NLFGDILSDE A + G +G+ PSA++ E+ L+EP GSAP IAGKNIANP A Sbjct: 214 QTIVTTNLFGDILSDEAAGLIGGLGLAPSANIGEKN-ALFEPVHGSAPQIAGKNIANPTA 272 Query: 301 QILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYV 359 IL+ L+L++ L+ A IE+A+ + L EG+ T DL + T EM IAR++ Sbjct: 273 MILTTTLMLKH-LNKKQEAQKIEKALQKTLAEGLVTPDL---GGKLGTMEMAAEIARHL 327 >UniRef50_Q46NL2 Tartrate dehydrogenase n=12 Tax=Bacteria RepID=Q46NL2_RALEJ Length = 358 Score = 208 bits (530), Expect = 2e-52, Method: Compositional matrix adjust. Identities = 141/365 (38%), Positives = 202/365 (55%), Gaps = 19/365 (5%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPAT 61 ++ Y IAV+PGDGIG EV+ + ++VL+A +F ++ + YD A + G +P Sbjct: 4 NQQYKIAVIPGDGIGNEVVPEGIRVLEAASAKFGFKLAFTTYDWSCARYHSQGSMMPSDG 63 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 +E +DA+ G+VG P PD L+P+R+ F + NLRP +L G+ C Sbjct: 64 IERLRDSDAIFLGAVGFPG----VPDHVSLWNLLIPIRREFDQYVNLRPVRLLPGVP--C 117 Query: 122 PLRADIAANGFDILCVRELTGGIYFGQPKGREGSG-QYEKAFDTEVYHRFEIERIARIAF 180 PL A+ D VRE T G Y Q GR +G ++E ++ R +RI R AF Sbjct: 118 PL-ANKKPGDIDFWIVRENTEGEY-SQVGGRMFAGTEHEFVTQEAIFTRRGTDRIMRYAF 175 Query: 181 ESARKR-RHKVTSIDKAN-VLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPS 238 + A+K R+ VTS K+N + S W E + EYPD+ +ID + P Sbjct: 176 DLAKKLGRNHVTSATKSNGIFHSMPFWDERFAAVGAEYPDIRTDQYHIDILAARFAMSPE 235 Query: 239 QFDVLLCSNLFGDILSDECAMITGSMGMLPSASLN-EQGF-GLYEPAGGSAPDIAGKNIA 296 +FDV++ SNLFGDILSD ITG++ + PSA++N E+ + ++EP GSAPDIAG+ IA Sbjct: 236 RFDVVVGSNLFGDILSDLGPGITGTIAVAPSANINPERKYPSMFEPVHGSAPDIAGQGIA 295 Query: 297 NPIAQILSLALLLRYSLDADDAACAIERAINRALE--EGIRTGDLARGAAAVSTDEMGDI 354 NPI QI S A++L + L +AA AI +AI L + + T DL A ST +MG Sbjct: 296 NPIGQIWSGAMMLEH-LGQPEAAAAIMQAIETVLTHPDRVHTPDLGGRA---STQQMGAE 351 Query: 355 IARYV 359 IAR V Sbjct: 352 IARAV 356 >UniRef50_A6WAX5 3-isopropylmalate dehydrogenase n=20 Tax=Bacteria RepID=A6WAX5_KINRD Length = 377 Score = 208 bits (530), Expect = 2e-52, Method: Compositional matrix adjust. Identities = 133/353 (37%), Positives = 198/353 (56%), Gaps = 31/353 (8%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMR-ITTSHYDVGGAAIDNHGQPLPPA 60 SK Y +AVL GDGIGPE++ ++K+LDA I + +G +AID +G+ P Sbjct: 21 SKQYSLAVLHGDGIGPEIVPASVKILDAAVAAAGATPIAWTELPLGRSAIDEYGEHTPTK 80 Query: 61 TVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLP---LRKHFKLFSNLRPAKLYQGL 117 T++ ++ D L G + +P R L P +RKHF LF+N+RPAK ++G Sbjct: 81 TLDALDEVDGWLLGPHDSAAY------PEPYRSQLNPSGTIRKHFGLFANIRPAKAFRGG 134 Query: 118 EAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYH----RFEIE 173 A G D++ VRE T G Y + G+G+ D + H R E Sbjct: 135 NAIV--------EGTDLVIVRENTEGFYADR-NTFAGTGEMMPTPDVAIMHGIITRAATE 185 Query: 174 RIARIAFESARKRRHKVTSIDKANVLQSSI-LWREIVNEIATEYPDVELAHMYIDNATMQ 232 RIA AF+ AR R +VT + KANVL+ + L+R++ E+ +YPDV + +ID AT+ Sbjct: 186 RIAHEAFQLARTRDKRVTIVHKANVLKMTTGLFRDVCREVGKQYPDVAINDFHIDAATVH 245 Query: 233 LIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAG 292 L++ +FDV++ N+FGDILSD + GS+G+ PS + + + + + GSAPDIAG Sbjct: 246 LVRRADKFDVIVTENMFGDILSDLAGEVAGSLGIAPSIN-SSATHAMAQASHGSAPDIAG 304 Query: 293 KNIANPIAQILSLALLLRY-SLDADD-----AACAIERAINRALEEGIRTGDL 339 ++IANPIA ILS A+LLR+ + DD AA +E A++ + EG T D+ Sbjct: 305 RDIANPIAMILSSAMLLRWLAAKFDDEKIARAADIVEAAVDLTVAEGATTPDM 357 >UniRef50_D2SEJ6 3-isopropylmalate dehydrogenase n=3 Tax=Actinomycetales RepID=D2SEJ6_9ACTO Length = 340 Score = 207 bits (526), Expect = 7e-52, Method: Compositional matrix adjust. Identities = 139/356 (39%), Positives = 203/356 (57%), Gaps = 29/356 (8%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCE 66 +AV+PGDGIGPEV+ + LKVL AV A + ++ YD+G + G+ LP ++ Sbjct: 3 LAVIPGDGIGPEVVAEGLKVLRAV----APDVESTPYDLGASRWQRTGELLPDTVLDELR 58 Query: 67 QADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRAD 126 + DA+L G++G P +PP L LR NLRPA+L+ G+ R+ Sbjct: 59 RHDAILLGAIGDPS---VPPGILERGLLLR-LRFELDHHVNLRPARLFDGV------RSP 108 Query: 127 IAANG-FDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA-- 183 +AA G D+LCVRE T G Y G +E A + + F +ER+ R AFE A Sbjct: 109 LAAPGAIDMLCVREGTEGPYVGNGGVLRRDTPHEVATEVSLNTAFGVERVVRYAFERALA 168 Query: 184 RKRRHKVTSIDKANVL-QSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDV 242 R RRH +T I K NVL + LW V E++ E+P+V +A+ ++D A+M + DP +FDV Sbjct: 169 RPRRH-LTLIHKTNVLTHAGSLWSRTVEEVSAEFPEVTVAYQHVDAASMFFVTDPGRFDV 227 Query: 243 LLCSNLFGDILSDECAMITGSMGMLPSASLNEQGF--GLYEPAGGSAPDIAGKNIANPIA 300 ++ NLFGDI++D A +TG +G+ S +L+ G ++EP GSAPDIAGK +A+P A Sbjct: 228 IVTDNLFGDIVTDLAAAVTGGIGLAASGNLDASGTNPSMFEPVHGSAPDIAGKGVADPTA 287 Query: 301 QILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIA 356 +LS+ LLL + AD A R +N A+ + T D A V T+++GD +A Sbjct: 288 TVLSVGLLLDHLGRADQA-----RKVNAAVAFDLSTRD---PEAQVRTEDVGDRLA 335 >UniRef50_Q7UTP0 3-isopropylmalate dehydrogenase n=1 Tax=Rhodopirellula baltica RepID=Q7UTP0_RHOBA Length = 364 Score = 206 bits (525), Expect = 9e-52, Method: Compositional matrix adjust. Identities = 118/316 (37%), Positives = 186/316 (58%), Gaps = 16/316 (5%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRF-AMRITTSHYDVGGAAIDNHGQPLPP 59 M +++H+ +L GDGIGPEV Q++++L+ ++ + + VG G+ LP Sbjct: 1 MPQSFHLVILGGDGIGPEVCDQSVRLLEIMQPHLDGVEFQLDRHSVGVGEYQRSGEALPQ 60 Query: 60 ATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEA 119 + + C +DAVL G++G P + P+ + E L LR+ +L+ +RP +LY EA Sbjct: 61 SAYDACLASDAVLLGAMGLPNVRY--PNGK-EIAPQLDLRERLQLYGGVRPIRLYH--EA 115 Query: 120 FCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYH--RFEIERIAR 177 PL+ D + VRE T G+++G R+ E T + R ER+ R Sbjct: 116 DTPLKGH-GPGEIDFVLVRESTEGLFYG----RDAIADLEADEATNLLRITRSASERVCR 170 Query: 178 IAFESARKR--RHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIK 235 +AFE+AR+R + VT IDKANVL S + +R + +E+A E+ D++ H+Y+D A + L++ Sbjct: 171 LAFETARRRDGKKTVTLIDKANVLSSMVYFRHVFDEVAKEFLDIKAEHVYVDAAALFLVR 230 Query: 236 DPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNI 295 P FDV++ N+FGDILSD A + G MGM PS + + +++P+ GSAPDIAG++I Sbjct: 231 RPQDFDVMVTENMFGDILSDLAAGLVGGMGMAPSGDIGDDA-AVFQPSHGSAPDIAGQSI 289 Query: 296 ANPIAQILSLALLLRY 311 ANPIA LS A++L + Sbjct: 290 ANPIAMHLSTAMMLEW 305 >UniRef50_B1MJY2 Tartrate dehydrogenase n=5 Tax=Bacteria RepID=B1MJY2_MYCA9 Length = 350 Score = 204 bits (519), Expect = 4e-51, Method: Compositional matrix adjust. Identities = 135/360 (37%), Positives = 192/360 (53%), Gaps = 18/360 (5%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPA 60 MS +A +PGDGIG +V +A+KV+D+ RI + +D G +PP Sbjct: 1 MSDRMRVATIPGDGIGVDVTREAVKVMDSATGG---RIEWTEFDYSCERYAKTGAMMPPD 57 Query: 61 TVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAF 120 DA+L G+VG P PD G L+PLR+ F + NLRP +L G+ + Sbjct: 58 APTTLAGFDAILLGAVGYPGV----PDDVSLWGLLIPLRRAFNQYVNLRPVRLLPGIAS- 112 Query: 121 CPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAF 180 PL A ++ ++ VRE T G Y Q E A V+ R ERI R AF Sbjct: 113 -PL-AGVSDEALSMVIVRENTEGEYSPIGGVHNRGNQNEFALQESVFTRIGCERIIRYAF 170 Query: 181 ESARKRRHKVTSIDKAN-VLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQ 239 E A +V S K+N ++ S W I NEIA EYP M++D +++ DP+ Sbjct: 171 ELAASAGFRVCSATKSNGIIHSMPYWDSIFNEIAAEYPQTPSVSMHVDALAARMVSDPAS 230 Query: 240 FDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQ--GFGLYEPAGGSAPDIAGKNIAN 297 DV++ SNLFGDILSD A ITG +G+ S ++N + ++E GSAPDIAG+ IAN Sbjct: 231 LDVIVASNLFGDILSDLAAAITGGLGLAASGNINPERTAISMFESVHGSAPDIAGQGIAN 290 Query: 298 PIAQILSLALLLRYSLDADDAACAIERAINRALEEG-IRTGDLARGAAAVSTDEMGDIIA 356 P+AQIL+ A+LL + L+ A I A+++ L +G +RT DL A +T+++G IA Sbjct: 291 PVAQILAGAMLLDH-LNEPATANKIRLAVDQVLSDGRVRTPDLGGTA---TTEQLGTAIA 346 >UniRef50_B3TCK6 Putative isocitrate/isopropylmalate dehydrogenase n=2 Tax=environmental samples RepID=B3TCK6_9ARCH Length = 339 Score = 203 bits (516), Expect = 9e-51, Method: Compositional matrix adjust. Identities = 126/365 (34%), Positives = 202/365 (55%), Gaps = 35/365 (9%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPA 60 MS Y+I+++ GDGIGPE+ AL +L+A+ + F + + + G A + N G+ LP Sbjct: 1 MSGKYNISLVTGDGIGPEISESALSILEAINDNFPLSLEIKKLEAGDAVLKNTGKALPDE 60 Query: 61 TVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAF 120 T E + +DA L VG + + ++ LR+ L++N+RPAK Y + + Sbjct: 61 TFEAIKNSDACLKAPVG-----------ESAKDVIVYLRRMLDLYANIRPAKSYPNMPS- 108 Query: 121 CPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAF 180 LR D+ D++ VRE T +Y G+ G AF + +RIA AF Sbjct: 109 --LRDDV-----DLVIVRENTEDLYTGE---EFDIGDAAVAF--RIISEKASKRIANYAF 156 Query: 181 ESARKRR-HKVTSIDKANVLQSSI-LWREIVNEIATEYPDVELAHMYIDNATMQLIKDPS 238 A KR+ KVT + K+NV++ + L+ +++A ++PDV+ MY+D M LI+ P Sbjct: 157 TIASKRKMKKVTCVHKSNVMKKTDGLFARTCSKVANDFPDVKFEEMYVDACAMNLIRQPQ 216 Query: 239 QFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANP 298 FDV++ +NLFGDILSDE A + G +GM P+A++ + FGL+EP G+A DIAGK IANP Sbjct: 217 LFDVIVTTNLFGDILSDESAQVVGGLGMAPAANIGDN-FGLFEPVHGAAFDIAGKQIANP 275 Query: 299 IAQILSLALLLRYSLDA-DDAAC-----AIERAINRALEEGIRTGDLARGAAAVSTDEMG 352 + ILS+ ++L + + +D C +E + ++ I+T D+ G + + Sbjct: 276 TSFILSIKMMLDWLGNKHNDQKCIEVGQKLEDVVYDIVKNNIKTKDI--GGDKTTMEFTK 333 Query: 353 DIIAR 357 +II+R Sbjct: 334 EIISR 338 >UniRef50_UPI0001B4F4BD putative isocitrate/isopropylmalate dehydrogenase / tartrate dehydrogenase ttuC n=1 Tax=Streptomyces hygroscopicus ATCC 53653 RepID=UPI0001B4F4BD Length = 357 Score = 203 bits (516), Expect = 1e-50, Method: Compositional matrix adjust. Identities = 124/334 (37%), Positives = 182/334 (54%), Gaps = 13/334 (3%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPAT 61 +K +AV+PGDGIGPEV+ + L A R+ + +D GG G +PP Sbjct: 5 TKVVRLAVIPGDGIGPEVVAATVPALRAALEADGHRLDVTSFDWGGERYLRQGAAMPPDA 64 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 + ++ DAVLFG+VG P P+ + G ++ LR+ L NLRP + + G+ Sbjct: 65 ADLVKKTDAVLFGAVGRPDV----PEHELVWGLIIGLRQQLDLAVNLRPVRAFPGV---- 116 Query: 122 PLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFE 181 P + +G D++ VRE T G Y G ++ + V+ R IER A AF Sbjct: 117 PTKVR-DTDGVDLVIVRENTEGEYVGAGGVAHAGSGHDLGIEVAVHSRRAIERAAHQAFA 175 Query: 182 SARKRRHKVTSIDKANVLQSSI-LWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQF 240 A +R ++ + K+N ++ LW +V E+ +YP VEL + +D ++I+ P Sbjct: 176 LAGRRSGRLCLVTKSNAMRYGYPLWDRVVREVGEQYPGVELETVLVDAMAARMIQAPRSL 235 Query: 241 DVLLCSNLFGDILSDECAMITGSMGMLPSASL--NEQGFGLYEPAGGSAPDIAGKNIANP 298 DVLL SNLFGDILSD A++ G MGM PSA++ + + G+YEP GSAPDIAGK +ANP Sbjct: 236 DVLLASNLFGDILSDLAAVLAGGMGMAPSANVLPDAEVPGIYEPVHGSAPDIAGKGVANP 295 Query: 299 IAQILSLALLLRYSLDADDAACAIERAINRALEE 332 +A +LS A+LL L DAA + A+ L + Sbjct: 296 VACLLSGAMLLE-DLGHTDAARRVRDAVADTLRD 328 >UniRef50_C3MI61 3-isopropylmalate dehydrogenase n=13 Tax=Proteobacteria RepID=C3MI61_RHISN Length = 371 Score = 202 bits (513), Expect = 2e-50, Method: Compositional matrix adjust. Identities = 118/314 (37%), Positives = 178/314 (56%), Gaps = 21/314 (6%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRF-AMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 IAVLPGDGIG EVM L++++A A + ++ G G LP +T++ C Sbjct: 10 IAVLPGDGIGREVMPACLELVNAATTMAGAPALAFQTHNAGAQYYAESGDALPASTLDAC 69 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLP---LRKHFKLFSNLRPAKLYQGLEAFCP 122 ++DA+LFG++G P P+ ++P LR LF+ +RP + + GL Sbjct: 70 RKSDAILFGAMGWPDIRF------PDGTEIIPQLDLRMELGLFAGVRPIRWFPGLPR--- 120 Query: 123 LRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFES 182 + D A D + VRE T G+++ +GR E+A+DT R +R+ AF+ Sbjct: 121 VLTDPRAEQIDFVLVREQTEGLFYA--RGRGEIRNDEEAYDTMQITRSGTQRVTEFAFDI 178 Query: 183 ARKRRHK-----VTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDP 237 AR+R+ + VT +DKANV QS +R++ +E+A + D+ H Y+D + ++K P Sbjct: 179 ARQRKRRGKPGNVTCVDKANVFQSMAFFRKVFDEVADRHSDLTKDHAYVDALALNMVKKP 238 Query: 238 SQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIAN 297 FDVL+ N+FGDILSD A + G MGM PSA + ++ GL++PA G+APDIAGK AN Sbjct: 239 WTFDVLVTENMFGDILSDLAAGLIGGMGMAPSADIGDK-HGLFQPAHGTAPDIAGKGCAN 297 Query: 298 PIAQILSLALLLRY 311 P A LS A++L + Sbjct: 298 PSAMFLSAAMMLDW 311 >UniRef50_Q2HAA2 Putative uncharacterized protein n=2 Tax=Chaetomium globosum RepID=Q2HAA2_CHAGB Length = 335 Score = 201 bits (511), Expect = 3e-50, Method: Compositional matrix adjust. Identities = 145/359 (40%), Positives = 196/359 (54%), Gaps = 43/359 (11%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAM--RITTSHYDVGGAAIDNHGQPLPPAT 61 ++I V GD GPEV+ +A+KVL A+ + + +GGA+I H PL Sbjct: 3 THNIVVFGGDHCGPEVVAEAVKVLRAIETHSPSVGKFNLQEHLLGGASIKVHNDPLTAKA 62 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQ-GLEAF 120 + + ADA+L G++GGP+W P +PE G LL LRK + NLRP L Sbjct: 63 LAAAKAADAILLGAIGGPEWGPSSP-VRPEEG-LLRLRKELGTYGNLRPCNFASDSLVDS 120 Query: 121 CPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIA- 179 PL+AD+ G D + VRELTGGIYFG +GSG A DT+ Y R EIERIAR+A Sbjct: 121 SPLKADVC-RGTDFIVVRELTGGIYFGARTEDDGSGF---AMDTDAYSRAEIERIARLAG 176 Query: 180 -FESARKRRHKVTSIDKANVLQSSILWREIVNEI-ATEYPDVELAHMYIDNATMQLIKDP 237 KV S+DKANVL +S LWR++V E+ A E+P +E+ H ID+A M ++K P Sbjct: 177 FLALGTSPPSKVWSLDKANVLATSRLWRKVVTEVFANEFPQLEVGHQLIDSAAMLMVKSP 236 Query: 238 SQFD-VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIA 296 + V++ SNLFGDI+SDE ++I GS+G I Sbjct: 237 RALNGVVVTSNLFGDIISDEASVIPGSIG---------------------------AGIV 269 Query: 297 NPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDII 355 NPI ILS+A++LRYSL+ A A+E A+ AL+ G RT DL A T +M D + Sbjct: 270 NPIGTILSVAMMLRYSLNLPKEAAAVEAAVRTALDNGTRTKDLGGSAG---TFQMADAV 325 >UniRef50_C7RJH9 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Accumulibacter phosphatis clade IIA str. UW-1 RepID=C7RJH9_9PROT Length = 364 Score = 200 bits (508), Expect = 7e-50, Method: Compositional matrix adjust. Identities = 123/340 (36%), Positives = 182/340 (53%), Gaps = 22/340 (6%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFA-MRITTSHYDVGGAAIDNHGQPLPPATV 62 +HIAVLPGDGIGPE++ +L VL+ + R + H + G A G + Sbjct: 6 RFHIAVLPGDGIGPEIVASSLHVLEVLNERMGGIGFDFWHLEGGAAHYQKTGTAFSDENM 65 Query: 63 EGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 C++ADAVL G++G P H+ E L LR L++ LRP + Y L Sbjct: 66 AACKKADAVLLGAIGLP---HVRYSDGTEVTTQLDLRVEMDLYAGLRPIRSYPSLPRVL- 121 Query: 123 LRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFES 182 D A+ D++ VRE T GI + + +G + A++T + R R++ AF Sbjct: 122 --VDKRASQIDLVLVREQTEGILYSRCRGTIEDDRV--AWETMMISRNGTSRVSEFAFRV 177 Query: 183 A------RKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKD 236 A R+R KV +D++N L S +R I E+A +P V + Y+D M+L+K Sbjct: 178 AERRAKSRRRPGKVLCVDRSNALTSMAFFRRIFGEVAERHPSVSADYAYVDTTAMKLVKS 237 Query: 237 PSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIA 296 P +FDVL+ N FG ILSD A + GS+G+ PSA + E+ +++PA GSAP IAG+ +A Sbjct: 238 PWEFDVLVTENAFGGILSDLAAGVVGSLGLAPSADIGEK-HAVFQPAHGSAPHIAGQGLA 296 Query: 297 NPIAQILSLALLLRYSLDAD------DAACAIERAINRAL 330 NP+AQILS+AL+L + D A +E A+ +AL Sbjct: 297 NPVAQILSVALMLDWLADQHGEPRLAHGARILEHAVEKAL 336 >UniRef50_B0RIP4 3-isopropylmalate dehydrogenase n=140 Tax=Bacteria RepID=LEU3_CLAMS Length = 355 Score = 199 bits (505), Expect = 2e-49, Method: Compositional matrix adjust. Identities = 126/316 (39%), Positives = 179/316 (56%), Gaps = 12/316 (3%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVL-DAVRNRFAMRITTSHYDVGGAAIDNHGQPLPP 59 M + +AV+PGDGIGPEV+ +AL+VL +AV ++ T+ Y G GQ L Sbjct: 1 MPRTISLAVVPGDGIGPEVVHEALRVLREAVPADVSL--DTTQYPFGAGHFLETGQILTD 58 Query: 60 ATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEA 119 + + Q DA+L G+VGG + ERG LL LR F + NLRP L G+ + Sbjct: 59 SDLAALAQHDAILLGAVGGDPRDARLAGGIIERGLLLKLRFAFDHYINLRPTALLPGVAS 118 Query: 120 FCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIA 179 PL A D + VRE T G Y G ++E A + V +ER R A Sbjct: 119 --PLAA---PGQVDFVVVREGTEGPYAGNGGVLRRGTEHEIATEVSVNTAHGVERTVRFA 173 Query: 180 FESARKR-RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDP 237 FE A KR R +VT + K NVL + LW+ V+ +A E+PDV + ++++D + L+ DP Sbjct: 174 FELAEKRDRKRVTLVHKTNVLTFAGSLWQRTVDRVAAEHPDVTVDYLHVDATMIFLVTDP 233 Query: 238 SQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGF--GLYEPAGGSAPDIAGKNI 295 S+FDV++ NLFGDI++D A I+G +G+ S ++N G ++EP GSAPDIAG+ Sbjct: 234 SRFDVIVSDNLFGDIITDLAAAISGGIGLAASGNVNPTGAFPSMFEPVHGSAPDIAGQQK 293 Query: 296 ANPIAQILSLALLLRY 311 A+P A ILS+ALLL + Sbjct: 294 ADPTAAILSVALLLDH 309 >UniRef50_A5UMS5 3-isopropylmalate dehydrogenase, LeuB n=8 Tax=Euryarchaeota RepID=A5UMS5_METS3 Length = 336 Score = 198 bits (503), Expect = 3e-49, Method: Compositional matrix adjust. Identities = 130/345 (37%), Positives = 185/345 (53%), Gaps = 32/345 (9%) Query: 5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEG 64 Y IAV+PGDGIG EVM + VLD + F + G + HG PLP T++ Sbjct: 11 YQIAVIPGDGIGKEVMEATISVLDELDVDFDYIYGIA----GDECNEEHGTPLPQETIDI 66 Query: 65 CEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 +DA LFG+ G + ++ +R+ K+F+NLRP K Y ++ Sbjct: 67 VRDSDACLFGAAG-----------ETAADVIVKIRQEMKMFANLRPVKSYPNTKSLF--- 112 Query: 125 ADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESAR 184 D + VRE T G+Y + G K V R ERI AF+ A+ Sbjct: 113 -----ENVDFMIVRENTEGLYIADQEEETEDGAIAK----RVITREAEERIIDYAFQYAK 163 Query: 185 -KRRHKVTSIDKANVLQSSI-LWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDV 242 R KVT++ KANVL+ + L+++I E+ +YPD++ Y+D M L+ P +F V Sbjct: 164 DNNRTKVTAVHKANVLKKTDGLFKKIFYEVGEKYPDIDTEDFYVDATAMYLVTQPQEFQV 223 Query: 243 LLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQI 302 ++ +NLFGDILSDE A + G +G++PSA++ G L+EP GSAPDIAG+ ANPIA + Sbjct: 224 VVTTNLFGDILSDEGAGLVGGLGLIPSANIGADG-ALFEPVHGSAPDIAGQQKANPIAMM 282 Query: 303 LSLALLLRYSLDADDAACAIERAINRALEEG-IRTGDLARGAAAV 346 LS ++LRY L +DAA + AI + L EG TGDL A + Sbjct: 283 LSAIMMLRY-LGENDAADKFDAAILKVLSEGKTLTGDLGGSATTM 326 >UniRef50_P42958 Probable tartrate dehydrogenase/decarboxylase n=8 Tax=Bacteria RepID=TTUC_BACSU Length = 354 Score = 198 bits (503), Expect = 3e-49, Method: Compositional matrix adjust. Identities = 126/354 (35%), Positives = 188/354 (53%), Gaps = 15/354 (4%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVL-DAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPAT 61 K + IA +PGDG+G EV+ A KVL A + + + + HG+ +P Sbjct: 4 KQFEIAAIPGDGVGKEVVAAAEKVLHTAAEVHGGLSFSFTAFPWSCDYYLEHGKMMPEDG 63 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 + Q +AV G+VG PK L PD G LL +R+ +L N+RPAK G+ + Sbjct: 64 IHTLTQFEAVFLGAVGNPK---LVPDHISLWGLLLKIRRELELSINMRPAKQMAGITS-- 118 Query: 122 PLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFE 181 PL + N FD + +RE + G Y + GR G E A V+ R ER+ R AFE Sbjct: 119 PL---LHPNDFDFVVIRENSEGEY-SEVGGRIHRGDDEIAIQNAVFTRKATERVMRFAFE 174 Query: 182 SARKRRHKVTSIDKAN-VLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQF 240 A+KRR VTS K+N + + W E+ + A +Y +E + +ID + P F Sbjct: 175 LAKKRRSHVTSATKSNGIYHAMPFWDEVFQQTAADYSGIETSSQHIDALAAFFVTRPETF 234 Query: 241 DVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGF--GLYEPAGGSAPDIAGKNIANP 298 DV++ SNLFGDIL+D + + GS+G+ PSA++N G ++EP GSAPDIAG+ +ANP Sbjct: 235 DVIVASNLFGDILTDISSSLMGSIGIAPSANINPSGKYPSMFEPVHGSAPDIAGQGLANP 294 Query: 299 IAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDL-ARGAAAVSTDEM 351 I QI + L+L + ++ I + + +GI+T D+ + A TDE+ Sbjct: 295 IGQIWTAKLMLDH-FGEEELGAKILDVMEQVTADGIKTRDIGGQSTTAEVTDEI 347 >UniRef50_Q46FW0 3-isopropylmalate dehydrogenase n=11 Tax=Euryarchaeota RepID=Q46FW0_METBF Length = 338 Score = 197 bits (502), Expect = 4e-49, Method: Compositional matrix adjust. Identities = 134/361 (37%), Positives = 202/361 (55%), Gaps = 35/361 (9%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFA---MRITTSHYDVGGAAIDNHGQPLPPATV 62 +AV+ GDGIG E++ A+KVLDA F + + + ++ G AI N+ T+ Sbjct: 2 RLAVIEGDGIGREIIPAAVKVLDAFGLEFEKVPLELGYTRWERTGTAISNNDL----ETI 57 Query: 63 EGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 +GC DAVLFG++ PD + LL +RK L++N+RP K G+ Sbjct: 58 KGC---DAVLFGAI------TTVPDPN-YKSVLLTIRKELDLYANVRPVKPLPGITGVT- 106 Query: 123 LRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFES 182 N FD + VRE T G+Y G E G E ++ V R ERIA A + Sbjct: 107 -----GRNDFDFIIVRENTEGLY----SGIEEIGP-ELSWTKRVVTRKGSERIAEYACKL 156 Query: 183 ARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDV 242 A+KR++K+T + K+NVL+S L+ ++ + A+ VE M +D+ LI P ++D+ Sbjct: 157 AKKRKNKLTIVHKSNVLKSDKLFLDVCRQTASAN-GVEYEDMLVDSMAYNLIMRPERYDI 215 Query: 243 LLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQI 302 ++ +NLFGDILSD CA + GS+G++PSA++ E+ + +EP GSAPDIAGK IANP+A I Sbjct: 216 VVTTNLFGDILSDMCAALVGSLGLVPSANIGEK-YAFFEPVHGSAPDIAGKGIANPLAAI 274 Query: 303 LSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYVAEG 362 L + +LL + + + I+ AI L++ I T DL A ST E+G+ +A YV Sbjct: 275 LCVKMLLEWM--GEPRSQIIDEAIAYVLQKKIITPDLGGTA---STMEVGNAVAEYVLSN 329 Query: 363 V 363 + Sbjct: 330 I 330 >UniRef50_UPI0001C310FF Tartrate decarboxylase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C310FF Length = 370 Score = 197 bits (501), Expect = 5e-49, Method: Compositional matrix adjust. Identities = 131/354 (37%), Positives = 193/354 (54%), Gaps = 20/354 (5%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 ++ +LPGDG+GPEVM +A K LDA+ + I + G A HG +P ++ Sbjct: 2 NVVLLPGDGVGPEVMAEARKALDALE----LGIAWTDVPWGSAWWAEHGTMMPADAIDVL 57 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 DA+L G+VG P PD + G +L +R+ L+ N+RPA+L +G+ PL A Sbjct: 58 RGHDAILMGAVGDPA----VPDDEALWGLILKIRQELDLWVNVRPARLLEGIPG--PL-A 110 Query: 126 DIAANGFDILCVRELTGGIYFGQPKGREGSG-QYEKAFDTEVYHRFEIERIARIAFESAR 184 A + D++ VRE + G Y G GR G ++ A ++ V+ R ER+ R AF A Sbjct: 111 GRAPHDVDMVFVRENSEGEYAGV-GGRVHRGFGHDVAIESSVFTRRGCERVIRYAFGMAS 169 Query: 185 KRRHKVTSIDKANVLQSSI-LWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVL 243 R+ + + K+N + W EIV E+ E+P V + M +D + +LI+DP DV+ Sbjct: 170 ARKGVLVNATKSNASRFGFPFWDEIVAEVGAEFPGVVVDRMLVDALSARLIRDPGSVDVV 229 Query: 244 LCSNLFGDILSDECAMITGSMGMLPSASLNEQGF--GLYEPAGGSAPDIAGKNIANPIAQ 301 + SNLFGDIL+D A + G MGM SA+L+ G L+EP GSAPDIAG+ IANP+ Sbjct: 230 VASNLFGDILTDIAAALQGGMGMAASANLSPGGGVPALFEPVHGSAPDIAGRGIANPVGA 289 Query: 302 ILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDII 355 I S AL+L L A + + + A+ G RT D+ +T E+GD + Sbjct: 290 IWSAALMLE-QLGAGEGSRRLMDALETVCRRGPRTRDV---GGTATTAEVGDAV 339 >UniRef50_B0ER68 Tartrate dehydrogenase, putative n=2 Tax=Entamoeba RepID=B0ER68_ENTDI Length = 370 Score = 196 bits (499), Expect = 9e-49, Method: Compositional matrix adjust. Identities = 130/359 (36%), Positives = 202/359 (56%), Gaps = 21/359 (5%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 + I V+PGDGIG EVM++A K+ ++ + I + D G G+ +P ++ Sbjct: 10 QHKIIVIPGDGIGVEVMSEAEKMFQSLN----LPIQRDYVDWGIQHYLKTGKVVPIDYID 65 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 +Q DA+L GS+G P+ LP E L+ +R+ F LRPAK + G+ PL Sbjct: 66 QVKQYDAILLGSLGDPR--TLPDYVTLE--PLIQMRQQLDQFLCLRPAKHFPGIPT--PL 119 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 + DIL VRE + G Y + E A ++ V+ R +ER+ R AFE++ Sbjct: 120 KK----CEIDILVVRENSEGEYSNIGGIFKSGTPDEFAIESAVHTRRGLERVIRYAFEAS 175 Query: 184 RKRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDV 242 RKRR+ VT K+N ++ +LW + IA EYPDV Y+D + +++K+PS+FDV Sbjct: 176 RKRRNHVTLATKSNAMKYGMVLWDSVFEAIAMEYPDVTAEKYYMDALSAEIVKNPSKFDV 235 Query: 243 LLCSNLFGDILSDECAMITGSMGMLPSASLN-EQGF-GLYEPAGGSAPDIAGKNIANPIA 300 ++ SNLF DI+SD + GSMG+ PSA++N E+ F L+EP GSA DIAGK I +PI Sbjct: 236 IVGSNLFCDIISDLTVTVAGSMGIAPSANINPERTFPSLFEPVHGSALDIAGKGICDPIG 295 Query: 301 QILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYV 359 + + +++L + L + + IE AI ++ + I T D+ +T+E+G+ IA Y+ Sbjct: 296 TMRASSMMLEF-LGYSEESVLIEEAIQSSILQKITTIDI---GGTKTTNEVGNFIADYI 350 >UniRef50_B8N3I6 Tartrate dehydrogenase, putative n=3 Tax=Trichocomaceae RepID=B8N3I6_ASPFN Length = 398 Score = 195 bits (495), Expect = 2e-48, Method: Compositional matrix adjust. Identities = 123/342 (35%), Positives = 189/342 (55%), Gaps = 16/342 (4%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRF-AMRITTSHYDVGGAAIDNHGQPLPPATV 62 Y IA +PGDGIG EV+ A++V++ + I +H G A HG+ + + Sbjct: 46 TYRIASIPGDGIGIEVVDAAIQVVEKLAKTLGTFNIDFTHIPWGTAYYKEHGRYVSEDCL 105 Query: 63 EGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 + + DA LFG+VG P PD G LL LR +L++N+RP + + G + CP Sbjct: 106 DTLRKFDAGLFGAVGAPD----VPDHISLWGLLLALRGPLQLYANVRPVRTFPGTK--CP 159 Query: 123 LRADIAANGFDILCVRELTGGIYFGQPKGREGSGQ-YEKAFDTEVYHRFEIERIARIAFE 181 L + A G D + VRE + G Y GQ GR GQ +E A + ++ R IERI R AFE Sbjct: 160 L--NTATEGIDWMLVRENSEGEYSGQ-GGRSHVGQPWEAATEVAMFTRVGIERIMRFAFE 216 Query: 182 SARKR-RHKVTSIDKANVLQSS-ILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQ 239 A+ R R +T + K+N +++ +LW ++ E+A ++PDV M +D T++++ P Sbjct: 217 VAQSRPRKLLTVVTKSNSMRNGMVLWDQVAAEVAKDFPDVTWDKMLVDAMTVRMVAKPQS 276 Query: 240 FDVLLCSNLFGDILSDECAMITGSMGMLPSASLN--EQGFGLYEPAGGSAPDIAGKNIAN 297 D ++ +NL DILSD A + GS+G+ PS++L+ + ++EP GSA DI GK +AN Sbjct: 277 IDTIVGTNLHMDILSDLAAALAGSIGVAPSSNLDPTRKNPSIFEPVHGSAFDITGKGVAN 336 Query: 298 PIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDL 339 P+A S A +L + L +AA + + + GI T DL Sbjct: 337 PVATFWSAAEMLSW-LGEKEAAKQLMDCVEKVCAAGILTPDL 377 >UniRef50_Q58991 Homoisocitrate dehydrogenase n=21 Tax=Euryarchaeota RepID=AKSF_METJA Length = 347 Score = 194 bits (492), Expect = 6e-48, Method: Compositional matrix adjust. Identities = 128/358 (35%), Positives = 198/358 (55%), Gaps = 26/358 (7%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCE 66 + V+ GDGIG EV+ +A+K+L+ + ++ + G + +G LP T+E + Sbjct: 4 VCVIEGDGIGKEVIPEAIKILNELGEFEIIK-----GEAGLECLKKYGNALPEDTIEKAK 58 Query: 67 QADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRAD 126 +AD +LFG++ PK P + + + ++ LRK F L++N+RP + G+ AD Sbjct: 59 EADIILFGAITSPK----PGEVKNYKSPIITLRKMFHLYANVRPINNF-GIGQLIGKIAD 113 Query: 127 ---IAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 + A DI+ +RE T +Y G+ + + E+ V R ERI R AFE A Sbjct: 114 YEFLNAKNIDIVIIRENTEDLYVGRERLENDTAIAER-----VITRKGSERIIRFAFEYA 168 Query: 184 -RKRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFD 241 + R KV+ I KANVL+ + L+ E+ NEI Y ++E +D+ M LIK P +FD Sbjct: 169 IKNNRKKVSCIHKANVLRITDGLFLEVFNEIKKHY-NIEADDYLVDSTAMNLIKHPEKFD 227 Query: 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQ 301 V++ +N+FGDILSDE + + G +G+ PSA++ + L+EP GSAPDIAGK IANP+A Sbjct: 228 VIVTTNMFGDILSDEASALIGGLGLAPSANIGDDK-ALFEPVHGSAPDIAGKGIANPMAS 286 Query: 302 ILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYV 359 ILS+A+L Y + + I A+ L T DL + T ++GD I Y+ Sbjct: 287 ILSIAMLFDY-IGEKEKGDLIREAVKYCLINKKVTPDL---GGDLKTKDVGDEILNYI 340 >UniRef50_A8TPC9 3-isopropylmalate dehydrogenase n=3 Tax=Alphaproteobacteria RepID=A8TPC9_9PROT Length = 371 Score = 191 bits (486), Expect = 3e-47, Method: Compositional matrix adjust. Identities = 137/357 (38%), Positives = 186/357 (52%), Gaps = 27/357 (7%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVL-DAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATV 62 Y IAV+PGDGIGPEV ++VL A+ F I YD G G P AT Sbjct: 12 GYRIAVVPGDGIGPEVSAATVRVLTQALGTSFP--IEFRDYDAGAECFRRTGTAFPEATQ 69 Query: 63 EGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 C QA AVL G+ G P P + + + +R L++N+RP +L +G P Sbjct: 70 VACRQAHAVLHGAAGLPDV-LFPDGTEAGQDFSMKIRAALDLYANVRPIRLMEG----AP 124 Query: 123 LRADIAANGFD---ILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIA 179 R + G D VRE T G+Y + G GQ A DT V R +ERI R A Sbjct: 125 RR--LVGKGPDDIRFTIVRENTEGLYAARGGGNIIRGQI--ATDTLVMTREGVERIVRYA 180 Query: 180 FESARKRR-------HKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQ 232 E AR + +VT +DKANVL+S +REI + + + P +E+ H+ +D T+ Sbjct: 181 AELARDGQGAPADGVRRVTIVDKANVLRSYAFFREIADGVLADCPGIEVEHVIVDAMTVH 240 Query: 233 LIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAG 292 +I+ P FDV++C NLFGDILSD A I G MG+ PS + G ++ + GSAP IAG Sbjct: 241 MIERPEHFDVIVCENLFGDILSDLGAAIMGGMGLAPSGEIGRD-HGYFQGSHGSAPTIAG 299 Query: 293 KNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTD 349 K +ANPIA ILS A++L + L + A+ RA R E TG + + AV+ D Sbjct: 300 KGLANPIACILSGAMMLDW-LGKRHSDPALTRAAERIREA---TGAVLKAGRAVTPD 352 >UniRef50_D2EFL9 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Parvarchaeum acidiphilum ARMAN-4 RepID=D2EFL9_9EURY Length = 339 Score = 191 bits (484), Expect = 4e-47, Method: Compositional matrix adjust. Identities = 126/365 (34%), Positives = 194/365 (53%), Gaps = 35/365 (9%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPAT 61 +K + +AV+ GDG+GP+V+ +L VLDAV+ +F + I G ++ +G LP T Sbjct: 3 NKKWRVAVIKGDGVGPDVINASLLVLDAVKKKFNLDIEYVPAVAGLNTVEKYGTNLPKET 62 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLP-----LRKHFKLFSNLRPAKLYQG 116 ++ ++ D VL G P PE LP +RK+F L++++RP K Sbjct: 63 LDTLKETDCVLKG-----------PTTTPEGANSLPSANVGIRKYFDLYADVRPNKTLPN 111 Query: 117 LEAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIA 176 + + P D++ VRE T G+Y G + E V R ERI Sbjct: 112 VPSIKP--------NVDMVIVRENTEGMY----SGLDFRVNQETTIGIRVITRKACERIV 159 Query: 177 RIAFESARKRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIK 235 + AF+ A R+ VT + K NVL+ S ++++I E A ++PDV+ ++D T IK Sbjct: 160 KYAFKLAESRKKHVTLVHKGNVLKVSDGMFKDIFYEEAKKHPDVKADDAHVDAITQWFIK 219 Query: 236 DPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNI 295 P +DV++ NLFGDI+SDE AM+ G +G SA++ ++ + ++EP GS P G + Sbjct: 220 QPEFYDVIVTENLFGDIISDEAAMVVGGIGTGASANIGDK-YAMFEPIHGSVPKYTGMDK 278 Query: 296 ANPIAQILSLALLLRYSLDADDAACAIERAINRALEEG-IRTGDLARGAAAVSTDEMGDI 354 NPI I+S+ ++L + +D +A AIE A+ + LEEG I T DL G A S E+G Sbjct: 279 VNPIGTIMSVKMMLDW-MDYKEAGKAIEDAVYKVLEEGKILTYDLG-GTAKCS--EVGKE 334 Query: 355 IARYV 359 IA V Sbjct: 335 IASKV 339 >UniRef50_B1L3C1 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Korarchaeum cryptofilum OPF8 RepID=B1L3C1_KORCO Length = 334 Score = 190 bits (483), Expect = 6e-47, Method: Compositional matrix adjust. Identities = 125/357 (35%), Positives = 189/357 (52%), Gaps = 33/357 (9%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 IAV+PGDG+GPE++ + VL+ + + + + ++ G G LP T+ G Sbjct: 3 RIAVIPGDGVGPEIIDAVIPVLETLSDLMNLPLDLRFFEAGDETKRKRGVALPEETLNGV 62 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 +DA L ++G + R +LPLR+ L+ NLRPAK Y Sbjct: 63 MNSDATLMVAIG-----------ESAREVILPLRQKLDLYVNLRPAKSYP---------V 102 Query: 126 DIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARK 185 A GFD+ VRE T +Y G + A D + R ERI R + AR+ Sbjct: 103 PRAIPGFDLTIVRENTEDLYV-----MSGWRGLDTAVDLRIITRRASERICRFGYRYARE 157 Query: 186 R-RHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLL 244 R + +V + KANVL +L+RE+ + +A E + MY+D+A M++ D FDV++ Sbjct: 158 RGKSRVYVVHKANVLGGCMLFREVCSRVAEE-EGFDYREMYVDSAAMRIAMD-RPFDVII 215 Query: 245 CSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILS 304 +N+FGDILSD A G +GM PSA++ E ++EP G+AP+IAGKNIANP+A ILS Sbjct: 216 TTNMFGDILSDLAAAFIGGLGMYPSANIGESR-AIFEPVHGTAPEIAGKNIANPMATILS 274 Query: 305 LALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYVAE 361 A+++ + L + + IE A+ RA E G T D+ ++ T E+G I+ + E Sbjct: 275 AAMMMGW-LGHEGGSKLIEEAVRRACELGYTTPDV---GGSMRTKEVGLKISEIMRE 327 >UniRef50_Q0A635 Isocitrate/isopropylmalate dehydrogenase n=1 Tax=Alkalilimnicola ehrlichii MLHE-1 RepID=Q0A635_ALHEH Length = 382 Score = 189 bits (480), Expect = 1e-46, Method: Compositional matrix adjust. Identities = 135/368 (36%), Positives = 189/368 (51%), Gaps = 31/368 (8%) Query: 5 YHIAVLPGDGIGPEVMTQALKVL----DAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPA 60 + + VLPG+G+GPEV+ AL +L +A RF +R + +G A G+ L P Sbjct: 28 FLVGVLPGEGVGPEVIDVALSLLRLLGEATGQRFEVR---TGGPIGRQAERLTGRGLTPE 84 Query: 61 TVEGCEQ----ADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQG 116 + C Q AVL G GG + LR+HF L+ L P + + Sbjct: 85 VRDFCAQVFAQGGAVLCGPGGGRF--------------VYDLRRHFDLYCKLIPLRHWPA 130 Query: 117 LEAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIA 176 L LR + AA D+L VRE G+Y G+ G EG G A+ Y E+ERI Sbjct: 131 LADAGVLRPE-AARSADVLIVRENASGLYCGE-WGSEGEGAARSAYQVCRYRADEVERIL 188 Query: 177 RIAFESARKRRHKVTSIDK-ANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIK 235 R A A +RR + + K V S LW + + +A E+ V + +DNA QLI Sbjct: 189 RTALRLAGQRRGDLVVVTKPGGVPAISALWHDALTAVAGEHGAVRCRTLEVDNAAYQLIA 248 Query: 236 DPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNI 295 DP QFDV++C N+FGDIL D +++ GS GM S + G +Y+ A G+A D+AG++ Sbjct: 249 DPRQFDVIVCPNMFGDILGDCGSLLMGSRGMSWSGNYGAAGQAVYQTAHGAAWDLAGRDR 308 Query: 296 ANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGA--AAVSTDEMGD 353 ANPI Q+ SLA++LR S A A+E AI R L G+RT D+ +GA AV T MG Sbjct: 309 ANPIGQVCSLAMMLRESFRLPALADALETAIARTLARGVRTADI-QGAQPTAVGTRAMGQ 367 Query: 354 IIARYVAE 361 + + E Sbjct: 368 ALCASLTE 375 >UniRef50_Q0W5L4 3-isopropylmalate dehydrogenase n=14 Tax=root RepID=Q0W5L4_UNCMA Length = 380 Score = 189 bits (480), Expect = 1e-46, Method: Compositional matrix adjust. Identities = 128/384 (33%), Positives = 199/384 (51%), Gaps = 36/384 (9%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 +Y + V+ GDGIGPEV+ + KV+ A + + + G+ + ++++ Sbjct: 3 SYKVPVIAGDGIGPEVIAEGRKVIAAAQEVYNFDVEWIDMPFSADHYVKTGETISESSLK 62 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 + A+ GS+G + + P E+G LL +R ++ + NLRP KL +G+E PL Sbjct: 63 ELSKYRAIFLGSIGDDR--KVKPGVL-EKGILLTMRFYYDQYVNLRPVKLMEGVE--TPL 117 Query: 124 RADIAANGFDILCVRELTGGIYFG-QPKGREGSGQYEKAFDTEVYH-RFEIE-------- 173 + AA+ D VRE T Y G + ++G+ + E ++Y +F ++ Sbjct: 118 KGKTAAD-IDFYVVRENTEDFYVGIGGRSKKGTSKQELEVIRQMYSVKFGLDVETDSDEI 176 Query: 174 -------------RIARIAFESARKRRHK-VTSIDKANVLQSSI-LWREIVNEIATEYPD 218 RI +F+ A R K ++S+DKANVL WRE+ + A +YPD Sbjct: 177 AYQLGVVSKEGAKRIIEYSFDLANSRPKKHLSSVDKANVLTDIYGFWREVFTDTAAKYPD 236 Query: 219 VELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFG 278 V+ Y+D TM +K+P FDV++ N+FGDI++D AMI G +G+ P ++N +G Sbjct: 237 VKTDFNYVDAVTMWFVKNPEFFDVVVSPNMFGDIITDLGAMIQGGLGLAPGGNINPEGTS 296 Query: 279 LYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRAL-EEGIRTG 337 ++EP GGSAP G N NPIA I + A+LL + L AA I AI + L E+ IRT Sbjct: 297 MFEPMGGSAPKYKGLNKVNPIATIWAGAMLLEH-LGEKQAAAGIVDAIEQNLKEKKIRTY 355 Query: 338 DLARGAAAVSTDEMGDIIARYVAE 361 DL A T ++G IAR V + Sbjct: 356 DLGGSAG---TSDVGTDIARIVKQ 376 >UniRef50_Q5JFV8 Homoisocitrate dehydrogenase n=4 Tax=Thermococcaceae RepID=Q5JFV8_PYRKO Length = 347 Score = 189 bits (479), Expect = 2e-46, Method: Compositional matrix adjust. Identities = 124/307 (40%), Positives = 169/307 (55%), Gaps = 31/307 (10%) Query: 5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEG 64 Y +AV+PGDGIGPEV+ A++VL AV R + +Y+ G G P+ +E Sbjct: 2 YRVAVIPGDGIGPEVIDGAVRVLKAVTGR----VRFEYYEGGVDVFQECGSPIREEDLEE 57 Query: 65 CEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 ++DAVLFG+ P D R +L LRK L++NLR LR Sbjct: 58 IRRSDAVLFGAT------TTPFDLPGYRSLILTLRKELGLYANLR---------IIPDLR 102 Query: 125 ADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESAR 184 G +I+ VRE + G+YFG G+ +A D + R ERIAR A E A+ Sbjct: 103 -----TGREIVIVRENSEGLYFGI-----GAVVNGRAVDVRLITREGAERIARFAVEQAK 152 Query: 185 KRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLL 244 R +T + KANVL +R IV E+A E VE+ ID+ T++L+++P + V+L Sbjct: 153 ARGSFITFVHKANVLTGDKFFRRIVREVAGE-EGVEVRDAIIDSFTIKLVRNPWEHGVIL 211 Query: 245 CSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILS 304 NLFGDILSD + GS+G++PS + + G L+EP GSAPDIAGK IANPI ILS Sbjct: 212 SENLFGDILSDLATVHAGSIGIVPSGNYGD-GIALFEPVHGSAPDIAGKGIANPIGAILS 270 Query: 305 LALLLRY 311 A+LL Y Sbjct: 271 GAMLLDY 277 >UniRef50_P70787 Probable tartrate dehydrogenase/decarboxylase ttuC n=117 Tax=cellular organisms RepID=TTUC2_AGRVI Length = 364 Score = 187 bits (475), Expect = 5e-46, Method: Compositional matrix adjust. Identities = 125/364 (34%), Positives = 193/364 (53%), Gaps = 18/364 (4%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFA-MRITTSHYDVGGAAIDNHGQPLPPAT 61 + Y IA +P DGIGPEV+ L+VL+A+ R I T +D G +G +P Sbjct: 2 REYKIAAIPADGIGPEVIAAGLQVLEALEKRSGDFSIHTETFDWGSDYYKKNGVMMPADG 61 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 +E ++ DA+ FG+VG P PD G LP+ + F ++N+RP K+ G+ Sbjct: 62 LEQLKKFDAIFFGAVGAPD----VPDHITLWGLRLPICQGFDQYANVRPTKVLPGITP-- 115 Query: 122 PLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEK-AFDTEVYHRFEIERIARIAF 180 PLR + D + VRE + G Y G GR G E+ + ++ R + RI R AF Sbjct: 116 PLR-NCGPGDLDWVIVRENSEGEYSGH-GGRAHKGLPEEVGTEVAIFTRVGVTRIMRYAF 173 Query: 181 ESARKR-RHKVTSIDKANVLQSS-ILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPS 238 + A+ R R +T + K+N + ++W EI E++ E+PDV M +D T+++ P Sbjct: 174 KLAQARPRKLLTVVTKSNAQRHGMVMWDEIAAEVSKEFPDVTWDKMLVDAMTVRMTLKPQ 233 Query: 239 QFDVLLCSNLFGDILSDECAMITGSMGMLPSASLN-EQGF-GLYEPAGGSAPDIAGKNIA 296 D ++ +NL DILSD + GS+G+ P+A+++ E+ F ++EP GSA DI GK IA Sbjct: 234 SLDTIVATNLHADILSDLAGALAGSLGVAPTANIDPERRFPSMFEPIHGSAFDITGKGIA 293 Query: 297 NPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIA 356 NP+A + A +L + L DAA + A+ R E GI T D+ A T ++ D + Sbjct: 294 NPVATFWTAAQMLEH-LGEKDAATRLMSAVERVTEAGILTPDVGGTA---DTQQVTDAVC 349 Query: 357 RYVA 360 +A Sbjct: 350 EAIA 353 >UniRef50_Q0X0C1 Putative dehydrogenase n=2 Tax=Streptomyces RepID=Q0X0C1_9ACTO Length = 362 Score = 187 bits (474), Expect = 7e-46, Method: Compositional matrix adjust. Identities = 118/308 (38%), Positives = 165/308 (53%), Gaps = 17/308 (5%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYD-VGGAAIDNHGQPLPPATVEGC 65 IAV+PGDGIGPEV+ AL VLDA + T D V G+ L + ++ Sbjct: 22 IAVIPGDGIGPEVIEPALDVLDA----LGLGTRTDILDHVNADTYLRTGEALTGSDLDRI 77 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 ++A L G+VG P+ D RG L LR L+ N RPA+L+ + PLR Sbjct: 78 RSSEAALLGAVGDPRLG----DTSYVRGVLTTLRLELDLYVNYRPARLWH--DRLSPLR- 130 Query: 126 DIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARK 185 D A D + VRE T G+Y G G E A D ++ R + R+ AF +AR+ Sbjct: 131 DPARRAIDCVIVRENTEGLYSGIGGGARTGTPEEIAVDVDLSTRHGVSRVLEFAFSAARR 190 Query: 186 RRHKVTSIDKANVLQSS-ILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLL 244 V +DKAN +++ LW+ E +P + +H+Y+D A ++L DP+ FDV++ Sbjct: 191 ---SVCLVDKANAVRNGGQLWQRCWGEAVARHPHIATSHLYVDTAALRLATDPTGFDVIV 247 Query: 245 CSNLFGDILSDECAMITGSMGMLPSASLNE-QGFGLYEPAGGSAPDIAGKNIANPIAQIL 303 +N +GDILSD A + G +G+ SA+LN G L+EP GSAPDIAG ANP IL Sbjct: 248 TNNSYGDILSDLTAALAGGLGVAASANLNPVTGRALFEPVHGSAPDIAGSGTANPFGAIL 307 Query: 304 SLALLLRY 311 S+ALL + Sbjct: 308 SVALLAEH 315 >UniRef50_A5US63 Homoisocitrate dehydrogenase n=6 Tax=Chloroflexi (class) RepID=A5US63_ROSS1 Length = 362 Score = 183 bits (464), Expect = 9e-45, Method: Compositional matrix adjust. Identities = 133/365 (36%), Positives = 184/365 (50%), Gaps = 40/365 (10%) Query: 5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEG 64 Y I V+PGDGIG EV+ A+ VL A F + D G G+ LP AT+ Sbjct: 6 YTILVIPGDGIGREVIPAAVAVLRATGLPFHF----ENADAGWECFQRQGEALPSATLTA 61 Query: 65 CEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 ADA+LFG+V P + R ++ LR+ L++N+RP P R Sbjct: 62 ARAADAILFGAVASPGYP-----VAGYRSPIVRLRRELDLYANIRPVFDDLPENGSNPRR 116 Query: 125 ADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESAR 184 + D++ VRE T +Y G+ + + A V R RI R+A + AR Sbjct: 117 RKV-----DLVVVRENTEDVYAGRERVEDDGA---TAIAERVITRRASARIMRVACDLAR 168 Query: 185 KRRH----------KVTSIDKANVLQSSI-LWREIVNEIATEYPDVELAHMYIDNATMQL 233 RR +VT + KANVL+ + L+R + E+A YPD+++ M +D +QL Sbjct: 169 ARRSARNGSDAPPGRVTVVHKANVLRETCGLFRSVALEVAQAYPDLQIDEMLVDTCALQL 228 Query: 234 IKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGK 293 P +FDV++ +NLFGDILSD G +G+ PSA+L E+ L+EP G+APDIAGK Sbjct: 229 ATRPERFDVIVTTNLFGDILSDVACAWGGGLGLAPSANLGER-HALFEPVHGAAPDIAGK 287 Query: 294 NIANPIAQILSLALLL-----RYSLDADDA----ACAIERAINRALEEGIRTGDLARGAA 344 IANP+A I ALLL R D A + I+RAI G T DL G + Sbjct: 288 GIANPLAAIGCTALLLDHLAGRAPADLASAMRGWSARIQRAIRHVRAAGPHTPDL--GGS 345 Query: 345 AVSTD 349 AV+TD Sbjct: 346 AVTTD 350 >UniRef50_Q51945 Tartrate dehydrogenase/decarboxylase n=249 Tax=cellular organisms RepID=TTUC_PSEPU Length = 365 Score = 182 bits (463), Expect = 1e-44, Method: Compositional matrix adjust. Identities = 136/377 (36%), Positives = 198/377 (52%), Gaps = 35/377 (9%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDA--VRNRFAMRITTSHYDVGGAAID---NHGQP 56 + ++ IA +PGDGIG EV+ + ++VL+A +++ A+ T + A+ D HG+ Sbjct: 3 AHSFRIAAIPGDGIGLEVLPEGIRVLEAAALKHGLALEFDTFEW----ASCDYYLQHGKM 58 Query: 57 LPPATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQG 116 +P E +Q DA+ FG+V W PD G+LL R+ F + N+RP +L+ G Sbjct: 59 MPDDWAEQLKQYDAIYFGAV---DWPDKVPDHISLWGSLLKFRREFDQYVNIRPVRLFPG 115 Query: 117 LEAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIA 176 + C L A+ D + VRE T G Y + + E ++ R ++RI Sbjct: 116 VP--CAL-ANRKVGDIDFVVVRENTEGEYSSLGGIMFENTENEIVIQESIFTRRGVDRIL 172 Query: 177 RIAFESARKR-RHKVTSIDKANVLQSSI-LWREIVNEIATEYPDVELAHMYIDNATMQLI 234 + AF+ A KR R VTS K+N + S+ W + +A YP V +ID + + Sbjct: 173 KYAFDLAEKRERKHVTSATKSNGMAISMPYWDKRTEAMAAHYPHVSWDKQHIDILCARFV 232 Query: 235 KDPSQFDVLLC-SNLFGDILSDECAMITGSMGMLPSASLN-EQGF-GLYEPAGGSAPDIA 291 P +FDV++ SNLFGDILSD G++G+ PSA+LN E+ F L+EP GSAPDI Sbjct: 233 LQPERFDVVVVASNLFGDILSDLGPACAGTIGIAPSANLNPERNFPSLFEPVHGSAPDIF 292 Query: 292 GKNIANPIAQILSLALLL--------RYSLDADDAACAIERAINRALEEGIRTGDLARGA 343 GKNIANPIA I S AL+L RY DD AIER I +G T D+ Sbjct: 293 GKNIANPIAMIWSGALMLEFLGQGDERYQRAHDDMLNAIERVI----ADGSVTPDM---G 345 Query: 344 AAVSTDEMGDIIARYVA 360 +ST ++G I+ +A Sbjct: 346 GTLSTQQVGAAISDTLA 362 >UniRef50_Q2JUI3 Isopropylmalate/isohomocitrate dehydrogenase family protein n=19 Tax=Bacteria RepID=Q2JUI3_SYNJA Length = 368 Score = 181 bits (460), Expect = 3e-44, Method: Compositional matrix adjust. Identities = 134/376 (35%), Positives = 202/376 (53%), Gaps = 41/376 (10%) Query: 5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEG 64 Y + ++PGDGIGPEV VL+A + + + G I+ +G PLPP +E Sbjct: 3 YRVTLIPGDGIGPEVTRAMTTVLEAS----GVDLEWIRVEAGVEVIEKYGTPLPPQVLES 58 Query: 65 CEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 + + G +G P R + +RK L++NLRPAK G+++ P + Sbjct: 59 IRETRVAIKGPIGTPVGTGF-------RSVNVAIRKELDLYANLRPAKSLPGIKS--PFQ 109 Query: 125 ADIAANGFDILCVRE----LTGGIYF--GQPKGREG-------SGQYEK---AFDTEVYH 168 DI D++ VRE L GI F G P+ SG++ + A + Sbjct: 110 -DI-----DLVVVRENTEDLYAGIEFERGTPEAAHAREEMMRLSGKFIREGSAIGIKPIS 163 Query: 169 RFEIERIARIAFESARKR-RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYI 226 F RI + AFE AR+ R KVT++ KAN+++ + L+ ++ E+A EYPD+E + + Sbjct: 164 EFGSRRIVKFAFEYARQNGRKKVTAVHKANIMKFTDGLFLQVAREVAQEYPDIEFEDLIV 223 Query: 227 DNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGS 286 DN +QL++ P +DVL+ +NL+GDI+SD CA + G +G+ P A++ + G ++E GS Sbjct: 224 DNMCLQLMQKPQLYDVLVLTNLYGDIISDLCAGMIGGLGVAPGANIGD-GIAVFEAIHGS 282 Query: 287 APDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEG-IRTGDLARGAAA 345 AP AG+N NP A ILS A++LRY L +AA +E A+ + EG T DLA+G Sbjct: 283 APKYAGQNKVNPSALILSGAMMLRY-LGEREAAARVEAAVQSVIAEGKYVTYDLAQG-EP 340 Query: 346 VSTDEMGDIIARYVAE 361 V T EM + IA V E Sbjct: 341 VGTQEMAEAIAARVQE 356 >UniRef50_Q1IJA8 Isocitrate dehydrogenase (NAD+) n=19 Tax=Bacteria RepID=Q1IJA8_ACIBL Length = 348 Score = 179 bits (455), Expect = 1e-43, Method: Compositional matrix adjust. Identities = 126/359 (35%), Positives = 182/359 (50%), Gaps = 43/359 (11%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 Y I ++PGDGIGPEV + A++VL+A +F + G A + + + +P E Sbjct: 2 TYKITLIPGDGIGPEVTSAAVRVLEATGLKFEWE----SFAAGAEAYEKYKEYIPKELNE 57 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 E+ L G V P + LRK F+L++N+RP + G+ P Sbjct: 58 SIERTRIGLKGPVTTPIGGGFSSIN-------VELRKRFELYANVRPIRNLPGVHTRYP- 109 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEI------ERIAR 177 G D++ VRE T G+Y G E V +I RI++ Sbjct: 110 -------GVDLVVVRENTEGLYSG----------IEHEVVPGVVESLKIITEKASTRISK 152 Query: 178 IAFESARKR-RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIK 235 AF ARK R K+ SI KAN+++ S L+ I+ EYP++ +DN MQL+ Sbjct: 153 FAFNYARKMGRKKIHSIHKANIMKMSDGLFIRCSRNISKEYPEIIYGEHIVDNTCMQLVM 212 Query: 236 DPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNI 295 +P Q+D+LL NL+GDI+SD CA + G +G+ P A++ E+ ++E GSAPDIAGKNI Sbjct: 213 NPYQYDILLLENLYGDIVSDLCAGLVGGLGLAPGANIGERA-SIFEAVHGSAPDIAGKNI 271 Query: 296 ANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIR-TGDLARGAAAVSTDEMGD 353 ANP A I S L+LR+ LD DAA ++ A++ EG T D+ ST E D Sbjct: 272 ANPTAVIRSGILMLRH-LDEQDAANRVKAAVHHVYREGKHLTRDM---GGTTSTSEFAD 326 >UniRef50_C1XGT6 Homoisocitrate dehydrogenase n=1 Tax=Meiothermus ruber DSM 1279 RepID=C1XGT6_MEIRU Length = 335 Score = 174 bits (441), Expect = 4e-42, Method: Compositional matrix adjust. Identities = 132/363 (36%), Positives = 191/363 (52%), Gaps = 36/363 (9%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPA 60 MSK Y I ++ GDGIG EV+ A VL+A +F G + G +P A Sbjct: 1 MSKTYKICLIEGDGIGHEVIPAARLVLEATGLKFEF----VEAQAGWETFERIGTSVPEA 56 Query: 61 TVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAF 120 T+E DA LFG+ P + +P GA+ +R+ LF+N+RPAK + + Sbjct: 57 TLEAVTHTDATLFGAATSPT-KKVPGF----FGAIRYMRRKLDLFANVRPAK-HHPVPGS 110 Query: 121 CPLRADIAANGFDILCVRELTGGIYFGQPKGR-EGSGQYEKAFDTEVYHRFEIERI---- 175 P G D++ VRE T G+Y Q + EG E A V R RI Sbjct: 111 RP--------GVDLIVVRENTEGLYVEQERSYLEG----EIAIADTVITRKASARIGEYA 158 Query: 176 ARIAFESARKRRHKVTSIDKANVL-QSSILWREIVNEIATEYPDVELAHMYIDNATMQLI 234 AR+A RK+ H KANVL + L+ V A +P+V+ + IDN MQL+ Sbjct: 159 ARLAASRPRKQLHVA---HKANVLPMTQGLFMNTVLAEAARFPEVKTQDIIIDNCAMQLV 215 Query: 235 KDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKN 294 ++P +FDV++ +NLFGDI+SD A + G +G+ S ++ + ++EP GSAPDIAGK Sbjct: 216 RNPERFDVIVTTNLFGDIISDLTAGLVGGLGIAASGNIGIK-HAVFEPVHGSAPDIAGKG 274 Query: 295 IANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDI 354 IANP A ILS ++L + L +AA +E A+++ L+EG RT DL A +T + + Sbjct: 275 IANPAATILSGVMMLDH-LGEHEAARRVEAAVDKVLQEGPRTPDLGGNA---TTLQFAEA 330 Query: 355 IAR 357 +AR Sbjct: 331 VAR 333 >UniRef50_D0RN50 Threo-isocitrate dehydrogenase [NAD] n=1 Tax=alpha proteobacterium HIMB114 RepID=D0RN50_9RICK Length = 357 Score = 174 bits (441), Expect = 5e-42, Method: Compositional matrix adjust. Identities = 125/368 (33%), Positives = 194/368 (52%), Gaps = 35/368 (9%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 N VL GDGIGPE+ ++ VL A + +++ + ++G A++ H ++ Sbjct: 3 NLKFLVLEGDGIGPEIAKASVDVLQAALKLYDLKVNLVYEEIGFASLKKHKTTFRSEVLK 62 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLP---LRKHFKLFSNLRPAKLYQG-LEA 119 E+ D ++ G+ + PP E G L P +RK+F L++N+RPAK G LE Sbjct: 63 IAEKCDGMILGTCSHNDY---PP---TEEGGLNPSGVIRKYFDLYANVRPAKNRLGKLER 116 Query: 120 FCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEV----YHRFEIERI 175 F P+ G D L +RE T G Y + + G G+ D + R RI Sbjct: 117 F-PM-------GIDCLVMRENTEGFYSDRNMFK-GVGELMPTPDVAISIRNITRKGSTRI 167 Query: 176 ARIAFESARKRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLI 234 A I F+ A +RR K+ +I KANVL+ S L+ E +++ +YP+VE +D+ + LI Sbjct: 168 AEIGFKYAMERRKKLVAIHKANVLRYSDGLFLECARQVSKKYPEVEYKEQIVDSMSAMLI 227 Query: 235 KDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKN 294 +DPS FDV+L +NLFGD LSD + I G +G+ S + E + + + GSAPDIAGKN Sbjct: 228 RDPSVFDVILATNLFGDNLSDAASEIAGGLGLAESINAGEN-YCIAQAQHGSAPDIAGKN 286 Query: 295 IANPIAQILSLALLLRY------SLDADDAACAIERAINRA-LEEGIRTGDLARGAAAVS 347 IANP++ I S A++L + + + A IE AI++ + RT D+ +S Sbjct: 287 IANPVSLIGSTAMMLDWLGKKNNNQQLKEIAQMIEDAIDKTIINPKTRTSDI---GGNLS 343 Query: 348 TDEMGDII 355 T + D++ Sbjct: 344 TTDFTDVL 351 >UniRef50_Q5SIJ1 Homoisocitrate dehydrogenase n=13 Tax=cellular organisms RepID=Q5SIJ1_THET8 Length = 334 Score = 172 bits (437), Expect = 1e-41, Method: Compositional matrix adjust. Identities = 124/338 (36%), Positives = 179/338 (52%), Gaps = 29/338 (8%) Query: 5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEG 64 Y I ++ GDGIG EV+ A +VL+A + + + G + G +P TVE Sbjct: 3 YRICLIEGDGIGHEVIPAARRVLEAT----GLPLEFVEAEAGWETFERRGTSVPEETVEK 58 Query: 65 CEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 A LFG+ P +P GA+ LR+ L++N+RPAK + + P Sbjct: 59 ILSCHATLFGAATSPT-RKVPGFF----GAIRYLRRRLDLYANVRPAK-SRPVPGSRP-- 110 Query: 125 ADIAANGFDILCVRELTGGIYFGQPKGREGSGQY-EKAFDTEVYHRFEIERIARIAFESA 183 G D++ VRE T G+Y Q + +Y + A V + ERI R A A Sbjct: 111 ------GVDLVIVRENTEGLYVEQER------RYLDVAIADAVISKKASERIGRAALRIA 158 Query: 184 RKRRHKVTSI-DKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFD 241 R K I KANVL + L+ + V E+A ++P V + + +DN MQL+ P +FD Sbjct: 159 EGRPRKTLHIAHKANVLPLTQGLFLDTVKEVAKDFPLVNVQDIIVDNCAMQLVMRPERFD 218 Query: 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQ 301 V++ +NL GDILSD A + G +G+ PS ++ + ++EP GSAPDIAGK IANP A Sbjct: 219 VIVTTNLLGDILSDLAAGLVGGLGLAPSGNIGDT-TAVFEPVHGSAPDIAGKGIANPTAA 277 Query: 302 ILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDL 339 ILS A++L Y L +AA +E+A++ LE G RT DL Sbjct: 278 ILSAAMMLDY-LGEKEAAKRVEKAVDLVLERGPRTPDL 314 >UniRef50_D1B742 3-isopropylmalate dehydrogenase n=2 Tax=Synergistaceae RepID=D1B742_THEAS Length = 370 Score = 171 bits (433), Expect = 4e-41, Method: Compositional matrix adjust. Identities = 128/387 (33%), Positives = 196/387 (50%), Gaps = 48/387 (12%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATV 62 K+Y I ++PGDGIGPEV QA+KV++A + F + +HY G + Q LP + Sbjct: 2 KSYRIGLIPGDGIGPEVTAQAVKVMEAAGSLFGFSLELTHYPYGAEHYLSTRQVLPDHAL 61 Query: 63 EGCEQADAVLFGSVGGPKWEHLPPDQQP---ERGALLPLRKHFKLFSNLRPAKLYQGLEA 119 E E DA+L G++G P+ QP ERG LL LR HF ++N+RP + + Sbjct: 62 EEMEGLDALLLGAIGDPRV-------QPGILERGILLKLRFHFDQYANIRPVR------S 108 Query: 120 FCPLRADIAANGFDILCVRELTGGIYFGQPKGREGS---------------GQYE----- 159 F P + + +RE T +Y G +G+ GQ Sbjct: 109 FTP----GPLGSVNAVVIRENTEDLYVGIGSTGDGAVNLPLEVTRGGYVMKGQLSAFTTP 164 Query: 160 -KAFDTEV-YHRFE-IERIARIAFESARKR-RHKVTSIDKANVLQSSI-LWREIVNEIAT 214 K F +V +H + R + AF+ A +VT K+N ++ ++ +++A+ Sbjct: 165 PKRFAMQVAWHTLDGAARACQYAFDLALDLGAEEVTLATKSNAVRDLYGIFENACHQVAS 224 Query: 215 EYPDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNE 274 +Y V L +D +L++ P F V+LC N+FGDI+SD A I G MG+ PS ++ + Sbjct: 225 QYESVSLRVENVDALCYKLVRSPGDFRVILCPNMFGDIVSDLLAGIGGGMGLAPSGNVGD 284 Query: 275 QGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGI 334 + ++EP GSAPDIAG++ ANP+A ILS A+LLR+ L AA A+E A+ R L + Sbjct: 285 R-LSMFEPVHGSAPDIAGQDRANPVASILSGAMLLRH-LGETSAAKAMEDAVQRYLSGPV 342 Query: 335 RTGDLARGAAAVSTDEMGDIIARYVAE 361 + G + T GD + R + E Sbjct: 343 EELPIEMG-GRLGTRGAGDAVVRRLEE 368 >UniRef50_A9IDG2 Tartrate dehydrogenase n=5 Tax=cellular organisms RepID=A9IDG2_BORPD Length = 363 Score = 171 bits (432), Expect = 5e-41, Method: Compositional matrix adjust. Identities = 120/346 (34%), Positives = 179/346 (51%), Gaps = 20/346 (5%) Query: 3 KNYHIAVLPGDGIGPEVM---TQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPP 59 K Y IA +PGDGIG EV+ QA++VL F +D GG HG +P Sbjct: 2 KTYRIATIPGDGIGKEVIPAGRQAMQVLAETDGSFTFEF--QDFDWGGDYYRRHGVMMPA 59 Query: 60 ATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEA 119 +E DA+LFGS G P D G L + + ++N+RP +L G++ Sbjct: 60 DGLEPLRDKDAILFGSAGDPD----IADHITLWGLRLKICQGLDQYANVRPTRLLPGIDG 115 Query: 120 FCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSG-QYEKAFDTEVYHRFEIERIARI 178 PL+ A D + VRE + G Y G GR G E A D + R +ERI R Sbjct: 116 --PLKR-CTAEQLDWVIVRENSEGEYSGV-GGRVHQGLPIEAATDVSMMTRAGVERILRY 171 Query: 179 AFESARKR-RHKVTSIDKANVLQSS-ILWREIVNEIATEYPDVELAHMYIDNATMQLIKD 236 AF A+ R R ++T + K+N + + ++W EI EI+ E+PDV +D AT +++ Sbjct: 172 AFRLAQSRPRKQLTVVTKSNAQRHAMVMWDEIALEISREFPDVRWDKELVDAATARMVNR 231 Query: 237 PSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLN--EQGFGLYEPAGGSAPDIAGKN 294 P+ D ++ +NL DILSD A + GS+G+ P+ +++ +G ++EP GSA DI GK Sbjct: 232 PASLDTIVATNLHADILSDLAAALAGSLGIAPTGNIDPERRGPSMFEPIHGSAFDIMGKG 291 Query: 295 IANPIAQILSLALLLRYSLDADDAACAIERAINRAL-EEGIRTGDL 339 +ANPI S+ +LL + L AA + RA+ ++ + T DL Sbjct: 292 LANPIGTFWSVVMLLEH-LGEHQAAARMMRAVESVTADQALHTRDL 336 >UniRef50_Q55BI2 Isocitrate dehydrogenase [NAD] regulatory subunit A, mitochondrial n=35 Tax=Eukaryota RepID=IDHA_DICDI Length = 354 Score = 169 bits (427), Expect = 2e-40, Method: Compositional matrix adjust. Identities = 126/358 (35%), Positives = 178/358 (49%), Gaps = 42/358 (11%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPAT 61 SK + ++PGDGIGPE+ +V AV+ + G + Sbjct: 21 SKIQKVTLIPGDGIGPEISESVKRVFSAVKAPIEWETVVVDANTG----------ISKEV 70 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 +E + L G + P + Q L LRK F L++N+RP G + Sbjct: 71 IESISKNKIGLKGPISTP----IGTGHQSLN---LGLRKTFNLYANIRPCLSIPGHKT-- 121 Query: 122 PLRADIAANGFDILCVRELTGGIYFG---QPKGREGSGQYEKAFDTEVYHRFEIERIARI 178 N + + VRE T G Y G QP +G Q K E RIA Sbjct: 122 ------RYNNVNTVVVRENTEGEYSGIENQP--VKGVAQSIKIITKEAS-----TRIAHY 168 Query: 179 AFESARKR-RHKVTSIDKANVL-QSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKD 236 AF+ A R KVT I KAN++ QS L+ + E++T YP ++ + IDN MQL+ D Sbjct: 169 AFQYALANGRKKVTCIHKANIMKQSDGLFVKSCREVSTRYPSIKYEELTIDNNCMQLVLD 228 Query: 237 PSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIA 296 P+Q DV++ NL+GDI+SD CA + G +G+ PS ++ E G ++E G+APDIAGKN A Sbjct: 229 PNQMDVMVLPNLYGDIVSDLCAGLIGGLGLTPSGNIGENGSAIFEAVHGTAPDIAGKNKA 288 Query: 297 NPIAQILSLALLLRYSLDADDAACAIERAINRALEEG-IRTGDLARGAAAVS--TDEM 351 NP A ILS ++LR+ L A IE A+ L EG ++TGDL G ++ S TDE+ Sbjct: 289 NPTALILSSIMMLRH-LGHFHEASIIENAVLNTLTEGKVKTGDLG-GNSSCSEYTDEL 344 >UniRef50_B9KYU3 Isocitrate dehydrogenase (NADP) n=3 Tax=Bacteria RepID=B9KYU3_THERP Length = 496 Score = 168 bits (426), Expect = 3e-40, Method: Compositional matrix adjust. Identities = 120/358 (33%), Positives = 185/358 (51%), Gaps = 37/358 (10%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHG--QPLPPATVEG 64 + ++PGDGIGPE++ A ++++AV + + GA++ G +P T+E Sbjct: 23 VTLIPGDGIGPEIVESACRLIEAVGAPIEWEVRRA-----GASVFREGIASGVPDDTIES 77 Query: 65 CEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 ++ VL G + P E+ A + LRK F+ F+N+RP + + P R Sbjct: 78 IKRTRVVLKGPLETPV-------GYGEKSANVTLRKLFEAFANVRPVRELPSVP--TPYR 128 Query: 125 ADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRF----EIERIARIAF 180 D++ VRE +Y + +Y + + H+ E+I R AF Sbjct: 129 G----RNIDLVVVRENIEDLY--------AAIEYRETPGVTIAHKLISYKGSEKIIRFAF 176 Query: 181 ESARKR-RHKVTSIDKANVLQSSILW-REIVNEIATEYPDVELAHMYIDNATMQLIKDPS 238 E AR R KVT K+N+L+ + W + I EIA+EYPD+E H+ IDN QL+K P Sbjct: 177 ELARAEGRKKVTCATKSNILKLTEGWFQHIFEEIASEYPDIEANHLIIDNCAHQLVKAPE 236 Query: 239 QFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANP 298 QF+V++ +NL GDI+SD + + G +G S + + ++EP G+AP AGKN+ NP Sbjct: 237 QFEVIVTTNLNGDIISDLASGLVGGLGFAASGNYGHE-VAIFEPVHGTAPKYAGKNVINP 295 Query: 299 IAQILSLALLLRYSLDADDAACAIERAINRALEEG-IRTGDLARGAAAVSTDEMGDII 355 A IL+ ++LRY +D + A IE+A+ LEEG T D+ AVST D I Sbjct: 296 TAMILTAVMMLRY-IDEFETAETIEQALIVTLEEGKALTRDVVGDERAVSTTAFTDAI 352 >UniRef50_D0LNY3 3-isopropylmalate dehydrogenase n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LNY3_HALO1 Length = 400 Score = 168 bits (425), Expect = 3e-40, Method: Compositional matrix adjust. Identities = 118/352 (33%), Positives = 171/352 (48%), Gaps = 23/352 (6%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 +Y + +LPGDGIGPEVM QA +L+AV +R GG HG P E Sbjct: 9 SYQVVLLPGDGIGPEVMAQARDLLEAVAEPSGVRFELDEIPCGGRFYLEHGARDWPEDAE 68 Query: 64 G-CEQADAVLFGSVGGPKWEHLPP-----DQQPERGALLPLRKHFKLFSNLRPAKLYQGL 117 C AD +L G+VG P + P A++ R L++N+RP KL G+ Sbjct: 69 ARCRGADVILLGAVGWPSPDGPGPVMMGNGNMAGHSAVIGNRVDLDLYANVRPVKLLPGV 128 Query: 118 -EAFCPLRADI-AANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERI 175 R + D++ +RE T G+Y G G A DT + R ERI Sbjct: 129 AHRISGTRQQVWRPEHVDMVILRENTEGLYAGMGGQLRVGGSASVATDTRLITRRGCERI 188 Query: 176 ARIAFESARKRRH--------KVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYID 227 R AFE +R +VT I K NVL+ L+ E+ E+A+EYPD+ +D Sbjct: 189 IRRAFELCEQRGRGAPGDGVKRVTGIVKHNVLEGCKLFAEVFAEVASEYPDIANELAIVD 248 Query: 228 NATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSA 287 T L+ P +DV + +NLFGDI++D +++ G MGM ++ ++ ++EP GSA Sbjct: 249 AFTQWLVTQPEHYDVCVTTNLFGDIVTDLASVLQGGMGMAVGCNVGDE-HAMFEPIHGSA 307 Query: 288 PDIAGKNIANPIAQILSLALLLRYSLDADD------AACAIERAINRALEEG 333 P +AGK+ ANP+A +L+ L + D A A+ERA+ E G Sbjct: 308 PPLAGKDEANPMAMLLATGEALAWLGQRHDDPRLRAIAHAVERAVATVAERG 359 >UniRef50_P33197 Isocitrate dehydrogenase [NADP] n=10 Tax=Bacteria RepID=IDH_THET8 Length = 496 Score = 167 bits (422), Expect = 7e-40, Method: Compositional matrix adjust. Identities = 121/352 (34%), Positives = 181/352 (51%), Gaps = 32/352 (9%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHG--QPLPPATVEG 64 I V+PGDGIGPE + LKVL+A + A + + GA++ G +P T+E Sbjct: 22 ITVIPGDGIGPECVEATLKVLEAAKAPLAYEVREA-----GASVFRRGIASGVPQETIES 76 Query: 65 CEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 + VL G + P E+ A + LRK F+ ++N+RP + F + Sbjct: 77 IRKTRVVLKGPLETPVGYG-------EKSANVTLRKLFETYANVRPVR------EFPNVP 123 Query: 125 ADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESAR 184 A G D++ VRE +Y G + S A ++ E+I R AFE AR Sbjct: 124 TPYAGRGIDLVVVRENVEDLYAGIEHMQTPS----VAQTLKLISWKGSEKIVRFAFELAR 179 Query: 185 KR-RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDV 242 R KV K+N+++ + + ++A EYPD+E H+ +DNA QL+K P QF+V Sbjct: 180 AEGRKKVHCATKSNIMKLAEGTLKRAFEQVAQEYPDIEAVHIIVDNAAHQLVKRPEQFEV 239 Query: 243 LLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQI 302 ++ +N+ GDILSD + + G +G PSA++ + ++E GSAP AGKN+ NP A + Sbjct: 240 IVTTNMNGDILSDLTSGLIGGLGFAPSANIGNE-VAIFEAVHGSAPKYAGKNVINPTAVL 298 Query: 303 LSLALLLRYSLDADDAACAIERAINRALEEG-IRTGDLA---RGAAAVSTDE 350 LS ++LRY L+ A IE A+ LEEG + TGD+ RGA E Sbjct: 299 LSAVMMLRY-LEEFATADLIENALLYTLEEGRVLTGDVVGYDRGAKTTEYTE 349 >UniRef50_A0P1S6 3-isopropylmalate dehydrogenase n=3 Tax=Rhodobacterales RepID=A0P1S6_9RHOB Length = 369 Score = 166 bits (420), Expect = 1e-39, Method: Compositional matrix adjust. Identities = 123/351 (35%), Positives = 178/351 (50%), Gaps = 44/351 (12%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRIT---TSHYD---VGGAAIDNHGQPLPPA 60 IA++ GDGIG +V A+ VL+ A++ T YD G G + Sbjct: 3 IALIKGDGIGVDVAEAAIAVLET-----ALKHTGEPAPRYDEIQAGAGYFKETGLDIEDG 57 Query: 61 TVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAF 120 E ADA+ G++G P H E L LR F L++ +RP K Y Sbjct: 58 GEERAGLADAIFLGAIGLPSIRHA---NGTEISPHLRLRDRFGLYAGVRPVKAYPN---- 110 Query: 121 CPLR-ADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAF---DTEVYHRFEIER-- 174 P R AD A G D++ +RE T G+++ + ++++ D EV I R Sbjct: 111 APQRLADPRAAGIDLVILRESTEGLFYS-------AAAHKRSLVVNDDEVQDVLRITRKT 163 Query: 175 ---IARIAFESARKRRHK-----VTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYI 226 + R AF ARKRR + +T +DKANV S +R+I +E+ +E+ DV + + Y+ Sbjct: 164 TTKLHRFAFNLARKRRERGHPGRLTCVDKANVFTSLAFFRQIFDEVKSEFADVPVGYNYV 223 Query: 227 DNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGS 286 D + L++ P +FDVL+ N+FGDILSD + G MGM + + GL++PA GS Sbjct: 224 DAQALDLVRKPWEFDVLVMENMFGDILSDLAGGLVGGMGMAACGEIGDT-TGLFQPAHGS 282 Query: 287 APDIAGKNIANPIAQILSLALLLRY---SLDADDAACAIERAINRALEEGI 334 APDI G++ ANP+A ILS AL+L Y LD A A E I+ A+E G Sbjct: 283 APDIMGEDKANPLAAILSAALMLDYLAEKLDKPSLADAAE-LIDSAVETGF 332 >UniRef50_A5FXZ9 3-isopropylmalate dehydrogenase n=2 Tax=Alphaproteobacteria RepID=A5FXZ9_ACICJ Length = 353 Score = 165 bits (418), Expect = 2e-39, Method: Compositional matrix adjust. Identities = 108/313 (34%), Positives = 159/313 (50%), Gaps = 25/313 (7%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCE 66 I +L GD IG E++ +A++V+ A R + I +G AA+D+ G LP T+E + Sbjct: 3 IGILNGDDIGHEIVPEAVRVMQAAAARTGLAIEWQDIPIGRAALDSLGSTLPDGTIERLD 62 Query: 67 QADAVLFGSVGGPKWEHLPPDQQPERGALLPL-RKHFKLFSNLRPAKLYQGLEAFCPLRA 125 D L G +G + +P P PL RKHF LF+N+RP K + L Sbjct: 63 ALDGWLLGPIGHMAYPKIPEAINPH-----PLLRKHFDLFANIRPVKSHAALPCL----- 112 Query: 126 DIAANGFDILCVRELTGGIYFGQPKGR--EGSGQYEKAFDT----EVYHRFEIERIARIA 179 G D++ VRE G QP GSG++ D V R ++AR A Sbjct: 113 ---HQGVDLVIVRENNEGF---QPDRNVVAGSGEFRPTPDVTISVRVITRNGSSKVARAA 166 Query: 180 FESARKRRHKVTSIDKANVLQSSI-LWREIVNEIATEYPDVELAHMYIDNATMQLIKDPS 238 FE AR RR +T++ K V + ++ E +A EYPDV +D M+L+ P Sbjct: 167 FELARARRRHLTAVHKDTVFKLGCGMFAEECRRLAAEYPDVTYDEAIVDTFAMRLVMTPQ 226 Query: 239 QFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANP 298 ++DV++ +N+FGDIL+DE A + G +GM + + + GSAPDIAG+ IANP Sbjct: 227 RYDVVVTTNMFGDILTDEAAGLVGGLGMAAGLCAGPR-HAMAQATHGSAPDIAGRGIANP 285 Query: 299 IAQILSLALLLRY 311 A I+S +LL + Sbjct: 286 YAMIMSGQMLLDW 298 >UniRef50_A9FME3 3-isopropylmalate dehydrogenase n=7 Tax=Proteobacteria RepID=A9FME3_SORC5 Length = 363 Score = 165 bits (417), Expect = 3e-39, Method: Compositional matrix adjust. Identities = 108/329 (32%), Positives = 178/329 (54%), Gaps = 14/329 (4%) Query: 17 PEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCE-QADAVLFGS 75 P V+ +A +L+ + R + I D+G G P + + AVL G+ Sbjct: 19 PSVIAEAKLLLELYQERAGLPIDLWELDLGADRYLRDGTTFPNQIQIAIQRECSAVLLGA 78 Query: 76 VGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRADIAANGFDIL 135 +G P+ P+ + R L +R + L++N+RP + + PL+ A + D + Sbjct: 79 LGDPR----VPNLEHARDILFGMRFGYDLYANVRPVRALS--DRLVPLKGRTAKD-IDFV 131 Query: 136 CVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARKR-RHKVTSID 194 RE T GIY G + E A + +V R +ERI R AF+ AR R +VT D Sbjct: 132 VFRENTEGIYVGMGGQFKRGTPDEVAINEDVNTRKGVERIIRAAFDYARANGRTRVTMAD 191 Query: 195 KANVLQSSI-LWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDIL 253 K+N ++ + LW + +E+ +YP+++ H+Y+D + +I+DP QF V++ +NLFGDI+ Sbjct: 192 KSNAMRHAHELWLRVFHEVRAQYPEIQSNHVYVDALCLYVIQDPGQFQVIVTNNLFGDIV 251 Query: 254 SDECAMITGSMGMLPSASLNEQG---FGLYEPAGGSAPDIAGKNIANPIAQILSLALLLR 310 +D A + G +GM SA+++ L+EP GSAP +AGK+IANP A +L+ LLL Sbjct: 252 TDLGAALQGGLGMAASANVHASDPARVALFEPVHGSAPPLAGKDIANPFAAMLTAGLLLA 311 Query: 311 YSLDADDAACAIERAINRALEEGIRTGDL 339 + L + IER +++AL++G+ T D+ Sbjct: 312 H-LGWPEEERRIERWVSQALDQGMCTVDV 339 >UniRef50_D2VFR4 Homo-isocitrate dehydrogenase n=1 Tax=Naegleria gruberi RepID=D2VFR4_NAEGR Length = 384 Score = 165 bits (417), Expect = 3e-39, Method: Compositional matrix adjust. Identities = 125/360 (34%), Positives = 187/360 (51%), Gaps = 53/360 (14%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAV--------RNRFAMRITTSHYDVGGAAIDNHGQPLP 58 I V+P DGIG EV+ A++V++A +N F+++ + G G+ LP Sbjct: 34 IGVIPADGIGKEVVPAAVQVMNAAIAKNVKAKQNDFSLQYIP--LEAGWETFQKTGKSLP 91 Query: 59 PATVEGCE-QADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGL 117 TVE + + D +FGSV P + + ++ +RK L++N+RP Q L Sbjct: 92 VETVEALKNKCDGAIFGSVQSPSHK-----VEGYSSPIVAMRKLVDLYANIRPC---QDL 143 Query: 118 EAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIER--- 174 A G D+L VRE T +Y + K EK T V R ER Sbjct: 144 -----------AKGIDMLIVRENTECLYIKKEKLTVDPTTGEK---TAVADRLITERASK 189 Query: 175 -IARIAFESARKRRH----KVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDN 228 IA IA++ A +R KVT + K+NVL S L+RE EI+ +YP V+ +D+ Sbjct: 190 RIAEIAYKLAVQRNKNGAPKVTIVHKSNVLSVSDGLFRESCLEISKKYPQVKTEEQLVDS 249 Query: 229 ATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAP 288 ++I DP+Q+DV++ NL+GDILSD + G +G+ SA+L++ F L EP GSAP Sbjct: 250 MVYKMILDPTQYDVVVAPNLYGDILSDAGSAFVGGLGVTASANLSD-SFALVEPVHGSAP 308 Query: 289 DIAGKNIANPIAQILSLALLLRYSLDADDAAC--------AIERAINRAL-EEGIRTGDL 339 DI GK I+NPIA I + A+LLR+ L D C +++RA+N + ++ + T DL Sbjct: 309 DIFGKKISNPIATIRACAMLLRH-LQEKDPKCSYLNEIADSMDRAVNVVMPDKTVTTPDL 367 >UniRef50_C7MQT6 Isocitrate/isopropylmalate dehydrogenase n=1 Tax=Saccharomonospora viridis DSM 43017 RepID=C7MQT6_SACVD Length = 356 Score = 163 bits (413), Expect = 9e-39, Method: Compositional matrix adjust. Identities = 119/342 (34%), Positives = 176/342 (51%), Gaps = 31/342 (9%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHY--DVGGAAIDNHGQPLPPATVE 63 I ++ GDGIGPE++ ++VLDA+ + D G G A V Sbjct: 5 RIGLIRGDGIGPEIVEATVRVLDALAELHPESRGWEYVEIDAGADTYRRTGVACAEADVR 64 Query: 64 GC-EQADAVLFGSVGGPKWEHLPPDQQP---ERGALLP-LRKHFKLFSNLRPAKLYQGLE 118 ++ DA L G VG LP + P E G L LR ++N+RP + + G+ Sbjct: 65 RLRDEVDATLKGPVG------LPDVRTPDGVEAGVLGGILRTGLDTYANIRPVRSWPGV- 117 Query: 119 AFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARI 178 P R + A+ D + VRE T G+Y + KG G DT + R R+AR Sbjct: 118 ---PSR--VRADRVDYVIVRENTEGLYASRGKG---VGNRWAVTDTLLTTREGTLRVARK 169 Query: 179 AFESARKRR-------HKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATM 231 AF A R+ +VT +DK+NVL+S +RE+V E+A E+P+VEL + Y D A Sbjct: 170 AFTLAAGRQGAPADGVRRVTCVDKSNVLRSHAFFREVVTEVAAEFPEVELEYRYADAAAQ 229 Query: 232 QLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIA 291 L+ P +FDVL+ N GD+LSD G +G+ P+ ++ + G +EP GSAPD+ Sbjct: 230 DLVLCPERFDVLVMENFLGDVLSDLGGATVGGVGLCPAGNVGD-GAAYFEPVHGSAPDLV 288 Query: 292 GKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEG 333 G+N ANP+ Q+L+ A+LL + D+AA + RA++ L G Sbjct: 289 GRNRANPVGQLLAAAMLLDHLGHVDEAA-RLRRAVSAVLAFG 329 >UniRef50_P40495 Homoisocitrate dehydrogenase, mitochondrial n=66 Tax=Dikarya RepID=LYS12_YEAST Length = 371 Score = 162 bits (411), Expect = 1e-38, Method: Compositional matrix adjust. Identities = 125/368 (33%), Positives = 190/368 (51%), Gaps = 32/368 (8%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATV 62 K+ I ++PGDGIG EV+ +VL+ + ++ + G G+ LP TV Sbjct: 22 KSLTIGLIPGDGIGKEVIPAGKQVLENLNSKHGLSFNFIDLYAGFQTFQETGKALPDETV 81 Query: 63 EGC-EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 + EQ LFG+V P + + ++ LR+ LF+N+RP K +G E Sbjct: 82 KVLKEQCQGALFGAVQSPTTK-----VEGYSSPIVALRREMGLFANVRPVKSVEG-EKGK 135 Query: 122 PLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFD-TEVYHRFEIERIARIAF 180 P+ D++ VRE T +Y K + D T+ RIA IA Sbjct: 136 PI---------DMVIVRENTEDLYIKIEKTYIDKATGTRVADATKRISEIATRRIATIAL 186 Query: 181 ESARKR-----RHKVTSIDKANVL-QSSILWREIVNEI----ATEYPDVELAHMYIDNAT 230 + A KR + +T K+NVL QS L+REI E+ +Y ++ +D+ Sbjct: 187 DIALKRLQTRGQATLTVTHKSNVLSQSDGLFREICKEVYESNKDKYGQIKYNEQIVDSMV 246 Query: 231 MQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDI 290 +L ++P FDV++ NL+GDILSD A + GS+G++PSA++ + + EP GSAPDI Sbjct: 247 YRLFREPQCFDVIVAPNLYGDILSDGAAALVGSLGVVPSANVGPE-IVIGEPCHGSAPDI 305 Query: 291 AGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEG-IRTGDLARGAAAVSTD 349 AGK IANPIA I S AL+L + L ++AA I +A++ L EG I+T DL G A + Sbjct: 306 AGKGIANPIATIRSTALMLEF-LGHNEAAQDIYKAVDANLREGSIKTPDL--GGKASTQQ 362 Query: 350 EMGDIIAR 357 + D+++R Sbjct: 363 VVDDVLSR 370 >UniRef50_A1WHK9 3-isopropylmalate dehydrogenase n=5 Tax=Proteobacteria RepID=A1WHK9_VEREI Length = 356 Score = 160 bits (405), Expect = 7e-38, Method: Compositional matrix adjust. Identities = 123/372 (33%), Positives = 187/372 (50%), Gaps = 37/372 (9%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCE 66 I VLPGDGIGPE+M A++VL+A RF + + H G A++ HG + PA +E + Sbjct: 3 IVVLPGDGIGPEIMAVAVRVLEAASKRFQLDLEIGHDIAGHASLQRHGATVTPALLEKVK 62 Query: 67 QADAVLFGSVGGPKWEHLPPDQQPERGALLP---LRKHFKLFSNLRPAKLYQGLEAFCPL 123 AD ++ G + + + +G + P RK L++N+RPA+ + G+ Sbjct: 63 AADGLMLGPMATYDF------KDEAKGEINPSKFFRKELDLYANIRPARTFPGMAH---- 112 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEV----YHRFEIERIARIA 179 F++ VRE T G Y GS + DT + R ERIAR A Sbjct: 113 ----RVGEFNLAVVRENTEGFY-ADRNIESGSSEMLITPDTVISLRRITRLCCERIARSA 167 Query: 180 FESARKRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPS 238 F+ AR R V+ + KANVL+ ++ +I ++A E+P V + +D +++ P Sbjct: 168 FDLARTRARHVSIVHKANVLKIGDGMFVDICRQVAREFPQVRVDDFIVDAMMAHVVRAPQ 227 Query: 239 QFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANP 298 +FDV++ +N+FGDILSD A ++GS+G+ S + + + + GSAPDIAG+NIANP Sbjct: 228 RFDVIVTTNMFGDILSDLTAELSGSLGLGGSLNAGKD-HAMGQAVHGSAPDIAGRNIANP 286 Query: 299 IAQILSLALLLRYSLDADD------AACAIERAINRALE--EGIRTGDLARGAAAVSTDE 350 + ILS LL + + AA AI+ AL+ EG R + T E Sbjct: 287 YSLILSAGQLLGWHGQRKNLPAFALAARAIDETATAALQAREGTRD-----AGGELGTAE 341 Query: 351 MGDIIARYVAEG 362 G R + EG Sbjct: 342 AGQSFVRRLLEG 353 >UniRef50_Q1RJU4 Isocitrate dehydrogenase [NADP] n=62 Tax=cellular organisms RepID=IDH_RICBR Length = 483 Score = 156 bits (395), Expect = 9e-37, Method: Compositional matrix adjust. Identities = 110/346 (31%), Positives = 174/346 (50%), Gaps = 47/346 (13%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAM-------RITTSHYDVGGAAIDNHGQPLPP 59 I + GDGIGPE+M L +L R + ++ HY G + Sbjct: 7 ITIAYGDGIGPEIMEAVLYILRKAEARIRLETIEVGEKLYVKHYSSG----------ISE 56 Query: 60 ATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGAL----LPLRKHFKLFSNLRPAKLYQ 115 + E E+ +L P P+ G + +RK +LF+N+RP+ Sbjct: 57 QSWESIERTGVIL-----------KAPITTPQGGGYKSLNVTIRKTLQLFANIRPSV--- 102 Query: 116 GLEAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERI 175 +F P + N ++ +RE +Y G + R+ YE ++ R E+I Sbjct: 103 ---SFYPFTKTLHPN-LNLTIIRENEEDLYAG-IEYRQTHNMYE---SVKLISRTGCEKI 154 Query: 176 ARIAFESARKR-RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQL 233 R AFE A K R KVT + K N+++ S ++ ++ NEIA EYP + H ID T +L Sbjct: 155 IRYAFEYAVKNNRKKVTCLSKDNIMKFSDGIFHKVFNEIAKEYPQINNEHYIIDIGTARL 214 Query: 234 IKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGK 293 P FDV++ SNL+GDI+SD A I+GS+G+ SA++ E + ++E GSAPDIAG+ Sbjct: 215 ATKPEIFDVIVTSNLYGDIISDVAAEISGSVGLAGSANIGEH-YAMFEAVHGSAPDIAGQ 273 Query: 294 NIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDL 339 +IANP + +L+ A+++ + D A IE A + +E+G+ T D+ Sbjct: 274 DIANP-SGLLNAAIMMLVHIGQGDIATLIENAWKKTIEDGMHTADI 318 >UniRef50_P50213 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial n=91 Tax=cellular organisms RepID=IDH3A_HUMAN Length = 366 Score = 156 bits (394), Expect = 1e-36, Method: Compositional matrix adjust. Identities = 117/362 (32%), Positives = 181/362 (50%), Gaps = 45/362 (12%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRN--RFAMRITTSHYDVGGAAIDNHGQPLPPATVEG 64 + ++PGDGIGPE+ +K+ DA + ++ R T+ GG + +P E Sbjct: 34 VTLIPGDGIGPEISAAVMKIFDAAKAPIQWEERNVTAIQGPGGKWM------IPSEAKES 87 Query: 65 CEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 ++ L G + P P L LRK F L++N+RP +E + Sbjct: 88 MDKNKMGLKGPLKTPIAAGHPSMN-------LLLRKTFDLYANVRPC---VSIEGYKTPY 137 Query: 125 ADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEI------ERIARI 178 D+ +I+ +RE T G Y G E V ++ +RIA Sbjct: 138 TDV-----NIVTIRENTEGEYSG----------IEHVIVDGVVQSIKLITEGASKRIAEF 182 Query: 179 AFESARK-RRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKD 236 AFE AR R VT++ KAN+++ S L+ + E+A D++ MY+D + +++D Sbjct: 183 AFEYARNNHRSNVTAVHKANIMRMSDGLFLQKCREVAESCKDIKFNEMYLDTVCLNMVQD 242 Query: 237 PSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIA 296 PSQFDVL+ NL+GDILSD CA + G +G+ PS ++ G ++E G+APDIAGK++A Sbjct: 243 PSQFDVLVMPNLYGDILSDLCAGLIGGLGVTPSGNIGANGVAIFESVHGTAPDIAGKDMA 302 Query: 297 NPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIR-TGDLARGAAAVSTDEMGDII 355 NP A +LS ++LR+ + D A IE A +++G T DL G A +D +I Sbjct: 303 NPTALLLSAVMMLRH-MGLFDHAARIEAACFATIKDGKSLTKDL--GGNAKCSDFTEEIC 359 Query: 356 AR 357 R Sbjct: 360 RR 361 >UniRef50_Q18GT1 3-isopropylmalate dehydrogenase n=8 Tax=Halobacteriaceae RepID=Q18GT1_HALWD Length = 334 Score = 155 bits (391), Expect = 3e-36, Method: Compositional matrix adjust. Identities = 120/342 (35%), Positives = 173/342 (50%), Gaps = 31/342 (9%) Query: 5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEG 64 + I V+ GDGIG EV+ A+ VL AV + + + G D G LP T E Sbjct: 7 HEIVVIEGDGIGQEVIPAAVAVLQAVDE---VGFSFTEKQAGDDTRDQTGAALPETTYEA 63 Query: 65 CEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 ADA LFG+ G + +LPLR+ F N+RPA+ Y G++A P Sbjct: 64 AADADATLFGAAGETAAD-----------VILPLREAVGSFVNIRPARAYPGVDALQPET 112 Query: 125 ADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESAR 184 D++ +RE T G+Y G E + + T V E++A A Sbjct: 113 --------DLVFLRENTEGVY----SGHEDRLSEDLSTLTRVITTSASEQLAEYACSYVT 160 Query: 185 KRR-HKVTSIDKANVLQSSI-LWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDV 242 +R ++ KANV+Q + +R+ V+ +A DV + +D ++ +P+QFDV Sbjct: 161 ERSIDGFHTVHKANVMQETDGRFRDAVSRVAASN-DVATNEVLMDAFATRVCLNPTQFDV 219 Query: 243 LLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQI 302 ++C NL GD+LSD A + G +G+LPSA++ Q L+EP G+APDIAG IANP A I Sbjct: 220 VVCPNLAGDVLSDLAAGLVGGLGLLPSANIG-QTNALFEPVHGTAPDIAGDGIANPSASI 278 Query: 303 LSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAA 344 LS +LL Y L DAA ++ A+ L G RT DL A+ Sbjct: 279 LSAGMLLEY-LGETDAATNVQMAVESVLNSGPRTPDLGGNAS 319 >UniRef50_Q8XSY8 Probable 3-isopropylmalate dehydrogenase oxidoreductase protein n=2 Tax=Proteobacteria RepID=Q8XSY8_RALSO Length = 365 Score = 154 bits (389), Expect = 5e-36, Method: Compositional matrix adjust. Identities = 103/312 (33%), Positives = 165/312 (52%), Gaps = 19/312 (6%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCE 66 I VLP DGIGPE++ A++VL + + F + + + DVG +++ +G L + + Sbjct: 3 ILVLPCDGIGPEIVGAAMEVLRSADSVFKLDLAFDYDDVGFTSLEKYGTTLRDEVLAKAK 62 Query: 67 QADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRAD 126 D V+ G+ + P + R R L++N+RPA+ L + +R Sbjct: 63 TYDGVILGTQSHADY---PAPDKGGRNVSAGFRIGLDLYANVRPARTRPFLTS--NMRE- 116 Query: 127 IAANGFDILCVRELTGGIYFGQPKGREGSGQYE------KAFDTEVYHRFEIERIARIAF 180 D++ +RE T G Y P G E A R ERIAR AF Sbjct: 117 --GRTMDLVIMREATEGFY---PDRNMTKGWAELMPSPDMAISLRKITRHCSERIARRAF 171 Query: 181 ESARKRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQ 239 E A KR+ KVT+I KAN + L+ E V ++A ++P+V L + ID +T L++ P + Sbjct: 172 ELAMKRKKKVTAIHKANSFHMTDGLFLECVRDVARDFPEVRLDDLLIDASTAHLVRAPER 231 Query: 240 FDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPI 299 FDVL+ +N +GDI+SD + ++GS+G L + + + GSAPDIAG++ ANP+ Sbjct: 232 FDVLVATNFYGDIISDLASELSGSLG-LAGSMMASDTHCCAQAQHGSAPDIAGQDKANPV 290 Query: 300 AQILSLALLLRY 311 + ILS+A+L+++ Sbjct: 291 SMILSVAMLIQW 302 >UniRef50_C7YX79 Putative uncharacterized protein (Fragment) n=1 Tax=Nectria haematococca mpVI 77-13-4 RepID=C7YX79_NECH7 Length = 352 Score = 152 bits (383), Expect = 2e-35, Method: Compositional matrix adjust. Identities = 117/343 (34%), Positives = 179/343 (52%), Gaps = 28/343 (8%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAV-RNRFAMRITTSHYDVGGAAIDNHGQPLPPAT 61 + + +A+LPGDG GP + + + LD + R R + S +D GG A+ P+T Sbjct: 8 RPFQVALLPGDGQGPYLASYVERTLDLIQRVRRNVSFKVSRHDFGGVALAAGAGTALPST 67 Query: 62 VEG-CEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQG-LEA 119 G C Q+DAVL G P++ +PERG LL LR+ + N+RP + L Sbjct: 68 TLGACRQSDAVLVCGCGDPRY-----GIEPERG-LLTLRQELEGCVNIRPVRFPSSQLVQ 121 Query: 120 FCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIA 179 + ++ DI R+LT G+Y+G+ R+ +G +A+DT Y R IERIAR+A Sbjct: 122 QSSYKPEVVEQ-LDITFFRDLTSGVYYGR---RKEAGDDGEAYDTTPYSRQTIERIARLA 177 Query: 180 FESARKRR--HKVTSIDKANVLQSSILWREIVNEI-ATEYPDVELAHMYIDNATMQLIKD 236 A + V SIDK NV+ +S LWR +V + E+P V L H+ +D A+M L D Sbjct: 178 GTYAMQFSPPKPVHSIDKHNVMATSRLWRSVVAHVFENEFPQVPLRHVLVDTASMILSSD 237 Query: 237 PSQFD-VLLCSNLFGDILSDECAMITGSMGMLPSASLN------EQGF-GLYEPAGGSAP 288 P + ++L N+FGDILSD+ I GS +L SA+++ +G G++EP + Sbjct: 238 PLSLNGIILTENMFGDILSDQAGGILGSPDVLASAAVSAIRRGGSRGTPGIFEPFNLN-- 295 Query: 289 DIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALE 331 G P+ I ++ L+L SL + A+ +AI R L+ Sbjct: 296 --PGGKTVGPLGSIQAVGLMLELSLGLAAESEALSKAIRRTLD 336 >UniRef50_A1WV93 3-isopropylmalate dehydrogenase n=8 Tax=Gammaproteobacteria RepID=A1WV93_HALHL Length = 389 Score = 149 bits (376), Expect = 1e-34, Method: Compositional matrix adjust. Identities = 134/377 (35%), Positives = 186/377 (49%), Gaps = 42/377 (11%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATV 62 +++ +AV+PGDGIGPEVM L+A+ A+ +T + D HG+ +P Sbjct: 6 ESWQVAVMPGDGIGPEVMAATRHALEALPGP-ALVLTELGWPAHAWHRD-HGEMMPADWR 63 Query: 63 EGCEQADAVLFGSVGGPKWEHLPPDQQ----PERGALLPL---RKHFKLFSNLRPAKLYQ 115 DA+L G++G P H D Q P+ +L PL RK L++ RPA Sbjct: 64 GQLAGYDALLLGALGDPGPSH---DAQRYCLPDGVSLAPLLQLRKGLDLWACERPAVPLA 120 Query: 116 GLEAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQ-YEKAFDTEVYHRFEIER 174 G A PL +D A D+L +RE + G Y Q GR +G E A EV+ R ER Sbjct: 121 G--APMPL-SDPRALHTDLLVIRENSEGEYVDQ-GGRLAAGTPRETATQLEVFTRAGTER 176 Query: 175 IARIAF-----------ESARKRRHK---------VTSIDKANVLQ-SSILWREIVNEIA 213 I R AF + R R+ V + K N +Q + LW E+ E+A Sbjct: 177 IIRHAFERAARRAEERRQGLRAPRYAAADGAADAAVCVVTKRNAVQYAGELWSEVFAEVA 236 Query: 214 TEYPDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLN 273 EYP + H ID M+ + P QFDV++ SNL GDIL+D A++ G MG+ PSA+LN Sbjct: 237 AEYPGIATHHELIDACCMKFVSQPWQFDVVVASNLHGDILTDLAAVLAGGMGVAPSANLN 296 Query: 274 EQGFG---LYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRAL 330 L+EP GSAPDIAG + A+P A +L+ A +L + + D A + RA+ Sbjct: 297 PADRSVPPLFEPTHGSAPDIAGADRAHPAAMLLTAAAMLEWMGEVDPVAARSAVQLQRAV 356 Query: 331 EEGI-RTGDLARGAAAV 346 E I G RG A V Sbjct: 357 AEDIAEHGMGGRGCAEV 373 >UniRef50_Q0BQF4 Isocitrate dehydrogenase (NADP) n=14 Tax=Proteobacteria RepID=Q0BQF4_GRABC Length = 348 Score = 148 bits (374), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 130/367 (35%), Positives = 184/367 (50%), Gaps = 37/367 (10%) Query: 1 MSKNYHI--AVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLP 58 MS+ I ++PGDGIGPE++ + VLDA+ + F S Y G AAI G PLP Sbjct: 7 MSQTTKIPATLIPGDGIGPEIVESVVSVLDALGSPFEW---DSQY-AGMAAIARVGDPLP 62 Query: 59 PATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLE 118 T++ L G + P R + LRK F+LF+N+RPA Sbjct: 63 RETIQSIHHNKLALKGPLTTPTGGGY-------RSVNVQLRKEFELFANVRPALTLIPGG 115 Query: 119 AFCPLRADIAANGFDILCVRELTGGIYFG----QPKGREGSGQYEKAFDTEVYHRFEIER 174 F DI +RE G Y P G + + A R R Sbjct: 116 RF---------ENVDITLIRENLDGFYAAFEHYMPIGDD---PHAVAMCAGFNTRTGCHR 163 Query: 175 IARIAFESARKR-RHKVTSIDKANVLQS-SILWREIVNEIATEYPD-VELAHMYIDNATM 231 I R AFE A + R KVT + KAN+L++ + ++ E EIA EY + +D M Sbjct: 164 IIRYAFEYAMQNGRKKVTLVHKANILKALTGIFLEAGKEIAKEYEGRIAFEERIVDACAM 223 Query: 232 QLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIA 291 QL+ DP +FDV++ +NLFGDILSD A + G +G+ P ++ +Q ++E GSAPDIA Sbjct: 224 QLVLDPGRFDVIVTTNLFGDILSDLIAGLIGGLGLAPGGNIGKQA-AIFEAVHGSAPDIA 282 Query: 292 GKNIANPIAQILSLALLLRYSLDADDAACAIERAIN-RALEEGIRTGDLARGAAAVSTDE 350 GK IANP+A +L+ A++L + + D A + AI LE+GIRT DL G A + + Sbjct: 283 GKGIANPLALMLAAAMMLDH-VGKTDLATRLRNAIRITTLEDGIRTPDL--GGTAKTREL 339 Query: 351 MGDIIAR 357 +I+R Sbjct: 340 TQALISR 346 >UniRef50_UPI000150AB37 dehydrogenase, isocitrate/isopropylmalate family protein n=1 Tax=Tetrahymena thermophila RepID=UPI000150AB37 Length = 636 Score = 147 bits (370), Expect = 7e-34, Method: Compositional matrix adjust. Identities = 113/365 (30%), Positives = 175/365 (47%), Gaps = 42/365 (11%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPAT 61 +N+ + + PG GIGPE+ + A + + I H+++ I+ G + Sbjct: 302 KQNHKVVLFPGHGIGPEISQAVCDIFAAAK----VPIDWEHHEIYTKPINEAGDLIK--- 354 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 E++ + G K P + R + +RK LF+N+RP + G++ Sbjct: 355 ----EESLNAVINYKWGLKGPFATPIGKGYRSLNVTMRKKLNLFANVRPCRSLAGVKT-- 408 Query: 122 PLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEI------ERI 175 + D++ +RE T G Y G E A V +I E I Sbjct: 409 ------PYSNVDLVTIRENTEGEYSG----------LEHAVVPGVVENLKIISQPACENI 452 Query: 176 ARIAFESARKR-RHKVTSIDKANVLQSSI-LWREIVNEIATEYPDVELAHMYIDNATMQL 233 AR AFE ARK R KV + KA V++ L+ +I++EYP++E ID M+L Sbjct: 453 ARYAFEFARKNNRKKVVACHKAGVMKKGDGLFINTCKKISSEYPEIEYTEEQIDTVCMKL 512 Query: 234 IKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGK 293 K+P FDV++ NL+GDI+SD CA + G +G+ S +++ +YE G+APDIAG Sbjct: 513 SKNPEVFDVMVMPNLYGDIVSDLCAGLIGGLGLTASGNISHTC-AVYEAVHGTAPDIAGL 571 Query: 294 NIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEG-IRTGDLARGAAAVSTDEMG 352 N ANP A +LS ++L+ ++ AIE A+ + L EG TGDL G A +TD Sbjct: 572 NKANPTALLLSGVMMLK-AMGLQKEGFAIEEAVIKTLSEGKFLTGDL--GGKATTTDYTK 628 Query: 353 DIIAR 357 +I Sbjct: 629 AVIGH 633 >UniRef50_Q1IMD5 3-isopropylmalate dehydrogenase n=3 Tax=cellular organisms RepID=Q1IMD5_ACIBL Length = 403 Score = 146 bits (368), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 115/373 (30%), Positives = 185/373 (49%), Gaps = 48/373 (12%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCE 66 + +PGDGIG +V+ QA++VL+AV H D+G N G LP T++ Sbjct: 6 VVTMPGDGIGNQVLPQAIRVLEAV----GFEANYVHADIGWECWCNEGNALPDRTIQLLR 61 Query: 67 QADAVLFGSVGGPKWEHLPPDQQPE-RGA-------LLPLRKHFKLFSNLRPAKLYQGLE 118 + LFG++ + + +PE RG ++ +R+ F L +RP + G Sbjct: 62 KHKLGLFGAITSKPKKAADAELKPELRGKGLSYFSPIVTMRQLFNLDVCMRPCLSFPG-- 119 Query: 119 AFCPLR--ADIAANGF-----DILCVRELTGGIYFG-----QPKG-REGSGQYEK----- 160 PL GF D++ R+ T G+Y G P+ R ++K Sbjct: 120 --NPLNFIRQTTCGGFEEPQVDVVVFRQNTEGLYAGVEWTNPPENVRTALASHKKFAAFA 177 Query: 161 -------AFDTEVYHRFEIERIARIAFESARKRRHK-VTSIDKANVL-QSSILWREIVNE 211 A + + +RI AF+ A+K R+K VT +K NVL ++S + E+ + Sbjct: 178 NTPGEELAVSVRIITKKNAQRICEAAFKHAKKYRYKNVTICEKPNVLRETSGMMEEVAKQ 237 Query: 212 IATEYPDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSAS 271 + +YP++ L ID TM L K+P ++ V++ SNLFGD++SD A + G +G S + Sbjct: 238 VQKQYPEIALWSTNIDAQTMWLTKNPEEYGVIVASNLFGDVISDAFAGLVGGLGFAASGN 297 Query: 272 LNEQGFGLYEPAGGSAPDIAGKN--IANPIAQILSLALLLRYSLDADDAACAIERAINRA 329 + ++ ++EP GSAP A N I NPIA ILS A++L + + + A I +AI Sbjct: 298 IGDE-VAVFEPTHGSAPKYAELNPSIVNPIAMILSAAMMLDH-IGESEKADRIRKAIADV 355 Query: 330 LEEG-IRTGDLAR 341 ++EG +RT D+ R Sbjct: 356 VKEGKVRTYDMMR 368 >UniRef50_C4Q3D3 Unc-13 (Munc13), putative n=38 Tax=cellular organisms RepID=C4Q3D3_SCHMA Length = 2313 Score = 144 bits (364), Expect = 4e-33, Method: Compositional matrix adjust. Identities = 111/351 (31%), Positives = 181/351 (51%), Gaps = 33/351 (9%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFA-MRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 +A++PGDGIGPE+ ++ +FA + I DV ++ +P ++++ Sbjct: 1979 VALIPGDGIGPEISAAVQEIF-----KFADVPIKWESVDVTPRPTEDGRFRMPQSSLDII 2033 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 + L G + P + + L LRK F L++N+RP K +G E P + Sbjct: 2034 RKHGIGLKGPLATPI-------GKGHQSLNLALRKEFNLYANVRPCKSIEGYET--PYK- 2083 Query: 126 DIAANGFDILCVRELTGGIYFG-QPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESAR 184 D++ VRE T G Y G + +G Q K E R+AR AF+ A+ Sbjct: 2084 -----NVDLVTVRENTEGEYSGIEHVIVDGVVQSIKLITEEAS-----RRVARFAFQYAK 2133 Query: 185 KR-RHKVTSIDKANVLQSSI-LWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDV 242 R VT++ KAN+++ S L+ + E A + ++E M++D + L++DP++FDV Sbjct: 2134 DNGRRSVTAVHKANIMRMSDGLFLRVCREEAAHHREIEFCDMFLDTVCLNLVQDPTRFDV 2193 Query: 243 LLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQI 302 L+ NL+GDILSD A + G +G+ PS ++ E G ++E G+APDIAG++ ANP A + Sbjct: 2194 LVMPNLYGDILSDLAAGLIGGLGVTPSGNIGETG-AIFESVHGTAPDIAGQDRANPTALL 2252 Query: 303 LSLALLLRYSLDADDAACAIERAINRALEEG-IRTGDL-ARGAAAVSTDEM 351 S ++LRY ++ + A IE A+ + E T DL R + T E+ Sbjct: 2253 FSAIMMLRY-MNLNKHADLIESAVLATIREAKYLTADLGGRSTCSQYTKEI 2302 >UniRef50_A5CDH3 Isocitrate dehydrogenase, NADP-dependent n=7 Tax=Rickettsiales RepID=A5CDH3_ORITB Length = 519 Score = 144 bits (363), Expect = 5e-33, Method: Compositional matrix adjust. Identities = 110/361 (30%), Positives = 182/361 (50%), Gaps = 42/361 (11%) Query: 7 IAVLPGDGIGPEVMTQALKVLD--AVRNRFAM-----RITTSHYDVGGAAIDNHGQPLPP 59 + + GDGIGPE+M + VL AV R ++ +Y G + Sbjct: 7 VTIAYGDGIGPEIMEAVVYVLKEAAVPLRLETIEIGEKLYNKYYTYG----------ITE 56 Query: 60 ATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEA 119 T + A+L G V P+ + + LRK L++N+RP+ + Sbjct: 57 DTWSQIFRTKALLKGPVTTPQ-------GGGYKSLNVTLRKTLGLYANVRPSC------S 103 Query: 120 FCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIA 179 + P + +A D++ +RE +Y G + + YE ++ R E+I R A Sbjct: 104 YFPF-VNTSAPEIDVVIIRENEEDLYAG-IEYHHTADTYESV---KLISRSGSEKIIRFA 158 Query: 180 FESARKRRHKVTS-IDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDP 237 FE A K K S K N+++ + ++ + NEIA++Y ++++ H ID + +LI P Sbjct: 159 FEYALKNNRKTISCFSKDNIMKFTDGIFHKTFNEIASQYSNIQVDHYLIDIGSARLISSP 218 Query: 238 SQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIAN 297 +FDV++ SNL+GDILSD A I+GS+G+ SA++ + + ++E GSAPDIAG+NIAN Sbjct: 219 QKFDVIVTSNLYGDILSDIAAKISGSIGLAGSANIGKD-YAMFEAVHGSAPDIAGQNIAN 277 Query: 298 PIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLAR---GAAAVSTDEMGDI 354 P + +L+ A+++ L + A IE A+ + +E+GI T D+ + V T E Sbjct: 278 P-SGLLNAAIMMLVHLGLTEHAAKIENALKKTIEDGIHTADIYNPSISSTKVGTKEFAQA 336 Query: 355 I 355 I Sbjct: 337 I 337 >UniRef50_Q4ZRW7 3-isopropylmalate dehydrogenase n=13 Tax=Proteobacteria RepID=Q4ZRW7_PSEU2 Length = 396 Score = 142 bits (358), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 125/385 (32%), Positives = 178/385 (46%), Gaps = 50/385 (12%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 I VLPGDGIG EVM AL V+ A+ F + D+G G+ +P T E Sbjct: 9 RICVLPGDGIGIEVMEAALPVIAALNLPFDL----VPADIGWQCWRAEGETVPARTWEIM 64 Query: 66 EQADAVLFGSVGG-PKWE---HLPPDQQPER----GALLPLRKHFKLFSNLRPAKLYQGL 117 DA L G++ P E LP Q + ++ LR++ L++N+RP G Sbjct: 65 ASCDATLLGAITSKPLAEAEAELPLTLQGQNRRYVSPVIQLRQNLDLYANVRPVTDMTG- 123 Query: 118 EAFCPLRADIAANGFDILCVRELTGGIYFGQPKG------------REGSG---QYEKAF 162 N F + +RE T G+Y G G RE G Q E Sbjct: 124 -----------ENRFRFVVIRENTEGLYAGLDFGCIPDALVPLLEEREALGAAWQREGQD 172 Query: 163 DTEVYHRFE----IERIARIAFESARKRRH-KVTSIDKANVLQ-SSILWREIVNEIATEY 216 D V R + + RI AFE ARK +VT +DK VL+ SS R I A Y Sbjct: 173 DATVTLRLQTRSGLMRIFEYAFEYARKNHFTRVTFVDKPMVLRHSSAFARGIFEATAQRY 232 Query: 217 PDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQG 276 PDV +D + +++ P +F V++ N+FGDILSD A + G +G PS + G Sbjct: 233 PDVSGVIENVDAVALWMVQRPERFGVIVAENMFGDILSDLGAGVMGGLGFAPSGNFGNSG 292 Query: 277 FGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRT 336 +EP GSAP AG N ANP A +++AL+L + ++AC I +A++ RT Sbjct: 293 -AYFEPVHGSAPAHAGLNKANPGAMFMAIALMLEHLGFPTESAC-ISQAVSLVSRTSTRT 350 Query: 337 GDLARGAAAVSTDEMGDIIARYVAE 361 DL + +T ++G+ I + E Sbjct: 351 YDL---GGSHTTAQVGEAIVQQCIE 372 >UniRef50_P28834 Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial n=7 Tax=Fungi/Metazoa group RepID=IDH1_YEAST Length = 360 Score = 140 bits (353), Expect = 8e-32, Method: Compositional matrix adjust. Identities = 109/358 (30%), Positives = 183/358 (51%), Gaps = 35/358 (9%) Query: 5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEG 64 + + ++PGDG+G E+ D+VR F ++ +H + + A VE Sbjct: 29 FTVTLIPGDGVGKEIT-------DSVRTIFEAENIPIDWETINIKQTDHKEGVYEA-VES 80 Query: 65 CEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 ++ L G W H P DQ + LRK +++N+ K +G++ P Sbjct: 81 LKRNKIGLKGL-----W-HTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRIP-- 132 Query: 125 ADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESAR 184 DI D++ +RE T G + G E +V R + ERIAR AF+ A+ Sbjct: 133 -DI-----DLIVIRENTEGEF----SGLEHESVPGVVESLKVMTRPKTERIARFAFDFAK 182 Query: 185 K-RRHKVTSIDKANVLQ-SSILWREIVNEIA-TEYPDVELAHMYIDNATMQLIKDPSQFD 241 K R VT++ KAN+++ L+R I+ EI EYPD++++ + +DNA+MQ + P QFD Sbjct: 183 KYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQFD 242 Query: 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAP-DIAGKNIANPIA 300 VL+ +++G IL + A + G G++ A+ + + ++EP DI G+N+ANP A Sbjct: 243 VLVTPSMYGTILGNIGAALIGGPGLVAGANFG-RDYAVFEPGSRHVGLDIKGQNVANPTA 301 Query: 301 QILSLALLLRYSLDADDAACAIERAINRALEEGIRTG-DLARGAAAVSTDEMGDIIAR 357 ILS L+L + L ++ A I +A++ + EG T D+ G ++ +TD +II + Sbjct: 302 MILSSTLMLNH-LGLNEYATRISKAVHETIAEGKHTTRDI--GGSSSTTDFTNEIINK 356 >UniRef50_A6G3V7 Probable 3-isopropylmalate dehydrogenase n=2 Tax=root RepID=A6G3V7_9DELT Length = 368 Score = 139 bits (350), Expect = 1e-31, Method: Compositional matrix adjust. Identities = 104/325 (32%), Positives = 154/325 (47%), Gaps = 33/325 (10%) Query: 20 MTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQ-PLPPATVEGCEQADAVLFGSVGG 78 M + LKVL AV + GG G P + C+ AD +L G+VG Sbjct: 1 MREGLKVLHAVSEPLGIEWAIEDVPCGGQYYLEQGDLDWPSDAPQKCDAADLILLGAVG- 59 Query: 79 PKWEHLPPDQQPERGALL----------PL---RKHFKLFSNLRPAKLYQGLE--AFCPL 123 W PD G +L P+ R L++N+RP KLY G++ Sbjct: 60 --W----PDPAGTGGPVLMKDNKMAGFSPVIGNRMRLNLYANVRPIKLYPGVQHRIHGGH 113 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 + A D++ +RE T G+Y G+ + A DT V R E++ R AFE Sbjct: 114 KQIWEAGKVDMVIIRENTEGLYAPTGGKLAPGGKADVAIDTRVITRRACEQVIRHAFELC 173 Query: 184 RKR--------RHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIK 235 ++R + +VT+I K NVL L+R++ EI EYP++E +D T L+ Sbjct: 174 KRRNKGAPKDGKLRVTAIIKDNVLHGCQLFRDVFFEIGAEYPEIEKDTAIVDAFTQWLVG 233 Query: 236 DPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNI 295 P +DV + SN+FGDI++D + + G MGM ++ + ++EP GSAP AGK+ Sbjct: 234 QPEYYDVCVTSNMFGDIVTDLASTLQGGMGMAVGGNIGKHN-AMFEPIHGSAPKHAGKDK 292 Query: 296 ANPIAQILSLALLLRY-SLDADDAA 319 NPIA ILS+ L + + DDA Sbjct: 293 VNPIAMILSVKEGLEWLAARKDDAT 317 >UniRef50_B1L5I7 Isocitrate dehydrogenase (NAD(+)) n=1 Tax=Candidatus Korarchaeum cryptofilum OPF8 RepID=B1L5I7_KORCO Length = 331 Score = 139 bits (350), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 104/339 (30%), Positives = 170/339 (50%), Gaps = 33/339 (9%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 IAV+ GDG+GPE+M L +L+ + I G + G+P+ +E Sbjct: 2 RIAVIKGDGVGPEIMGATLSLLERYIGADFIEIKA-----GKSYFIEEGKPIEDNAIEKI 56 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 + D++L G V P P LL R+ FKL++N+RP + Y+G Sbjct: 57 RECDSLLKGPVATPT----KGPSYPSVNTLL--RREFKLYANVRPFRSYEG--------- 101 Query: 126 DIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARK 185 I+ D + VRE +Y+G E ++A V + ERI+ AF A++ Sbjct: 102 -ISIRRIDTILVRENLECLYYGWEVEDE-----DRAIAMRVITKRGAERISEFAFNLAKR 155 Query: 186 R-RHKVTSIDKANVLQSSI-LWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVL 243 R +VT+I K N+L+ + L+ + +A+++ D+ +D A +L+K + FDV+ Sbjct: 156 EGRGRVTAIHKRNILKRTDGLFLDAFYRVASKF-DLRADDEIVDAAGYKLVKLDNAFDVM 214 Query: 244 LCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQIL 303 L NL+GDILSD A + GS+G+ SA + E F +EP G+ DIAGK +ANPI I+ Sbjct: 215 LTPNLYGDILSDVAAGVVGSIGLCGSAQIGED-FAAFEPIHGTGEDIAGKGVANPIGMII 273 Query: 304 SLALLLRYSLD---ADDAACAIERAINRALEEGIRTGDL 339 + +++L + + + I A++ + + I T DL Sbjct: 274 AASMMLDWLWERGRSPKRGEKIREAVDSVIRDRILTPDL 312 >UniRef50_A9A2N6 Isocitrate dehydrogenase (NAD(+)) n=11 Tax=Archaea RepID=A9A2N6_NITMS Length = 343 Score = 139 bits (350), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 119/371 (32%), Positives = 178/371 (47%), Gaps = 42/371 (11%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQP---- 56 MSK AV+ GDGIGPEV+ L+VL + + + + G D +G+ Sbjct: 1 MSK--KAAVMKGDGIGPEVVDSMLRVLKECNFQSELILC----EAGSEQWDKNGRKDASY 54 Query: 57 LPPATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQG 116 +P T++ E+ D G +P P R + LR+ F L++N+RP K Y Sbjct: 55 IPDVTMKILEETDCCFKGPT-----TTIPVPGAP-RSVAVTLRQKFDLYANIRPTKTYDR 108 Query: 117 LEAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIA 176 L P R D +C RE T G+Y G E + A R R+ Sbjct: 109 L---TPDRK------LDCVCFREATEGLY----TGVEAKITDDAAIAIRKITRQGSRRLI 155 Query: 177 RIAFESARK-RRHKVTSIDKANVLQSS--ILWREIVNEIATEYPDVELAHMYIDNATMQL 233 A + A K K+ ++ K N+L+ + I W E + A E D+EL+ +YIDN Q+ Sbjct: 156 DSAVDWANKFNMKKMVAVTKRNILKQTDGIFWDE--TQKAVEGTDIELSEIYIDNMAQQM 213 Query: 234 IKDPSQFD--VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIA 291 + QF+ VL+ +NLF DI+S+ + + GS+G++ SA++ + + ++E A GSAP A Sbjct: 214 VIATEQFNGAVLVSTNLFMDIISELASALVGSIGLIYSANIGDN-YAMFEAAHGSAPQFA 272 Query: 292 GKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEG-IRTGDLARGAAAVSTDE 350 G+N NP A +LS A + Y L D AI A + + EG T D+ A ST + Sbjct: 273 GQNKVNPTATVLSGAWMADY-LGERDVRDAIFAATEQVINEGKAVTWDIGGDA---STTQ 328 Query: 351 MGDIIARYVAE 361 M D I Y E Sbjct: 329 MTDAIITYAKE 339 >UniRef50_D2SD16 Malate/L-lactate dehydrogenase n=1 Tax=Geodermatophilus obscurus DSM 43160 RepID=D2SD16_9ACTO Length = 732 Score = 139 bits (349), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 113/362 (31%), Positives = 172/362 (47%), Gaps = 35/362 (9%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 +A+LPGDG+G EV+ ++L + R + +T + VG A G LP T+ C Sbjct: 3 RVALLPGDGVGEEVLDGPTRLLRLLAERGEVEVT-GPWPVGARAAAETGDVLPAGTLAAC 61 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPE-RGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 + ADA+L G+VG + +P P AL LR+ + L ++R Sbjct: 62 DAADAILLGAVG--EDPRVPAGVCPRPEVALHRLRERYDLRISVREIPF----------- 108 Query: 125 ADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFES-- 182 A+G ++ VR L GG Y G + E + R ER+A + + Sbjct: 109 ----ADGRELTVVRNLIGGSYGGA----DDRVLREDGSEAADVLRLTRERVAEVVHTACD 160 Query: 183 --ARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQF 240 R+ ++ S+DKAN+ + LWR++ ++A E +E+ H Y+D A +L Sbjct: 161 VLGRRGGGRLVSVDKANLYATGRLWRQVAGDVARER-GIEVEHRYVDRAAFELGSGAPVP 219 Query: 241 DVLLCSNLFGDILSDECAMITGSMGMLPSASLNE------QGFGLYEPAGGSAPDIAGKN 294 DVL+ L GDILSD A GS + SASL+ + GL+EPA GSAP A ++ Sbjct: 220 DVLVTEGLLGDILSDLAAGRAGSPALCGSASLHPGEPVRGRCVGLFEPAHGSAPRRALRD 279 Query: 295 IANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLA-RGAAAVSTDEMGD 353 +P+ L+LA LLR+ +A + A+ L G T DL G AA ST ++ D Sbjct: 280 QVDPLGGFLALAALLRHFPATREAGERVRAAVGAVLRSGPWTYDLVPEGGAAASTGQVAD 339 Query: 354 II 355 + Sbjct: 340 AV 341 >UniRef50_D1B6F8 3-isopropylmalate dehydrogenase n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B6F8_THEAS Length = 420 Score = 139 bits (349), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 122/390 (31%), Positives = 179/390 (45%), Gaps = 49/390 (12%) Query: 5 YHIAVLPGDGIGPEVMTQALKVL-------DAVRNRFAMRITTSHYDVGGAAIDNHGQPL 57 Y + +PGD G ++M AL VL D VR + + G D + Sbjct: 15 YKVCYMPGDDSGFDMMEGALVVLLSMDLPIDWVRADLGWCMWEKSVNKFGQG-DPRCNTV 73 Query: 58 PPATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGL 117 PP T++ +DA L ++ + + A+L +R+ F L+ NLRPAK L Sbjct: 74 PPETIDKIRSSDATLMAAITSKS------GVKGFKSAILQMRQLFDLYINLRPAKTLPDL 127 Query: 118 EAFCPLRADIAANGFDILCVRELTGGIY------------FGQPKGREGSGQY-EKAFDT 164 + PL+ D D++ RE T +Y F KG E + + A Sbjct: 128 GS--PLKGDPK---IDLVLFRENTEDLYSAVEFHPLPEEMFNLHKGMERFRKMGDVAVSW 182 Query: 165 EVYHRFEIERIARIAFESARKR-RHKVTSIDKANVLQSSI-LWREIVNEIATEYPDVELA 222 V+ ERI R AFE A+ R KV +KANV++ + + + I E+A EY + Sbjct: 183 RVFSSVGCERIIRAAFEYAKSTGRTKVHCCNKANVIRETDGMMKRIFLEVAKEYEQYGIT 242 Query: 223 HM--YIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLY 280 + D M LIK+P + V++ SN+FGDILSDE + +TG +G PS ++ E ++ Sbjct: 243 GIEENADATAMWLIKNPQDYQVIVTSNVFGDILSDEASQLTGGLGFAPSGNIGENT-AIF 301 Query: 281 EPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEG---IRTG 337 EP GS P A + NP A +L+ ++L Y L D A IE AIN L+E T Sbjct: 302 EPCSGSVPKYAHQYRVNPSAMLLTSKMMLEY-LGLDQAGQKIEWAINEVLKENRPKTLTY 360 Query: 338 DLARG--------AAAVSTDEMGDIIARYV 359 D+ R A ST EM IA+ + Sbjct: 361 DILRDFRNDPDWERNAASTIEMATAIAQKI 390 >UniRef50_Q0D0R7 Isocitrate dehydrogenase subunit 2, mitochondrial n=17 Tax=Dikarya RepID=Q0D0R7_ASPTN Length = 385 Score = 137 bits (345), Expect = 7e-31, Method: Compositional matrix adjust. Identities = 110/343 (32%), Positives = 176/343 (51%), Gaps = 35/343 (10%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 Y + ++ GDGIGPE+ +Q++K + + N I DV D +P +E Sbjct: 54 KYTVTLIEGDGIGPEI-SQSVKDIFSAAN---APIKWEPVDVTPILKDGK-TAIPDDAIE 108 Query: 64 GCEQADAVLFGSVGGPKWE-HLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 + L G + P + H+ + L LR+ F LF+N+RP + G + Sbjct: 109 SVRRNYVALKGPLATPVGKGHVSLN--------LTLRRTFNLFANVRPCRSIAGYKT--- 157 Query: 123 LRADIAANGFDILCVRELTGGIYFG-QPKGREGSGQYEKAFDTEVYHRFEIERIARIAFE 181 + D + +RE T G Y G + +G Q K E ER+ R AF+ Sbjct: 158 -----PYDNVDTVLIRENTEGEYSGIEHVVVDGVVQSIKLITKEAS-----ERVLRFAFQ 207 Query: 182 SARK-RRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQ 239 AR + KV + KA +++ S L+ EIA ++PDVE +DN+ ++++ DP+ Sbjct: 208 YARSINKKKVRVVHKATIMKMSDGLFLNTAREIAKDFPDVEFDAELLDNSCLKIVTDPTP 267 Query: 240 FD--VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIAN 297 ++ VL+ NL+GDILSD CA + G +G+ PS ++ ++ ++E GSAPDIAGK +AN Sbjct: 268 YNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDE-CSIFEAVHGSAPDIAGKGLAN 326 Query: 298 PIAQILSLALLLRYSLDADDAACAIERAINRALEEG-IRTGDL 339 P A +LS ++L++ + + A I++AI L EG TGDL Sbjct: 327 PTALLLSSIMMLQH-MGLHEHAGRIQKAIFDTLAEGKALTGDL 368 >UniRef50_B8NJA6 3-isopropymalate dehydrogenase, putative n=3 Tax=cellular organisms RepID=B8NJA6_ASPFN Length = 350 Score = 137 bits (344), Expect = 7e-31, Method: Compositional matrix adjust. Identities = 103/335 (30%), Positives = 160/335 (47%), Gaps = 25/335 (7%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCE 66 I VL G+GIGPE+ ++V++A ++ + A+ +G LPP ++ + Sbjct: 3 IGVLKGNGIGPEITAATIRVIEAT----GIQPEWDFIPIADEAVRLYGHALPPQVIQRIK 58 Query: 67 QADAVLFGSVGGPKWEHLPPDQQPERGALL------PLRKHFKLFSNLRPAKLYQGLEAF 120 + + K Q + + +R+ LF N RP + Y G+ Sbjct: 59 DVKFCIKAPLLAEKLHGRISCTQTDGSVVTYPSINNAIRRELNLFVNPRPIRGYVGISG- 117 Query: 121 CPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAF 180 D++ +RE+T Y G K E E + R ++++ AF Sbjct: 118 -------RHEKMDMVIMREITEDTYIGWEKPLEDGAAAEA---IKRVTRSASWKVSQYAF 167 Query: 181 ESARKR-RHKVTSIDKANVL-QSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPS 238 E ARK R KV+ + KANVL ++ L+ E+A YPD+ M ID A +++DP Sbjct: 168 EYARKHGRKKVSCLHKANVLHETDGLFLRTFQEVARLYPDIVGDDMMIDAACYSVVRDPC 227 Query: 239 QFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANP 298 FDV++ N +GDI SD A + GS+G+ P A++ + +E A G+APDIAG ANP Sbjct: 228 WFDVVVTVNQYGDIFSDLAAGLAGSLGLAPGANIGDSA-STFEAAHGAAPDIAGTGAANP 286 Query: 299 IAQILSLALLLRYSLDADDAACAIERAINRALEEG 333 IA ILS A LL ++ + AI A+ R +E G Sbjct: 287 IALILSGAELLAHA-GYGKGSEAIREAVTRVIEAG 320 >UniRef50_UPI000038E0FC 3-isopropylmalate dehydrogenase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI000038E0FC Length = 356 Score = 136 bits (343), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 96/346 (27%), Positives = 168/346 (48%), Gaps = 42/346 (12%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCE 66 IAV+PGDGIG E++ Q ++ ++ + + Y++ N G + + ++ + Sbjct: 4 IAVIPGDGIGKEIIPQVCDLVTSID----PSVNFTFYNISSERYINKGITIKDSEIDELK 59 Query: 67 QADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRAD 126 +++ FG++G + + P E+G +L LRK L+ N+RPA + + Sbjct: 60 SYNSIFFGAIGDFR---VKPGIM-EQGVILRLRKELDLYMNIRPAISF----------SR 105 Query: 127 IAANGFDILCVRELTGGIY------FGQPKGREGSGQY-------EKAFDTEVYH----- 168 I N + +RE Y + K G + D +Y+ Sbjct: 106 ITGNNIHMTILRENKEDFYSDISGSLNEHKLFRQKGNFYNYNIDINSESDDTIYYTMGFL 165 Query: 169 -RFEIERIARIAFESARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYID 227 R ++R +A++ A VT DKAN + LWREI E +E ++ Y D Sbjct: 166 SRKNLKRFFNMAYKIADTE--TVTITDKANAVDMYSLWREIAIE-ESEPAGKKINFEYAD 222 Query: 228 NATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSA 287 + +I +P ++ ++ NL+GDILSD + + G +G PS ++ + ++EP GSA Sbjct: 223 SLAYNMINNPLKYRYIIAPNLYGDILSDMSSAMVGGLGYAPSGNIGDYS-SMFEPVHGSA 281 Query: 288 PDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEG 333 PDIAGKNIANP+A ILS ++L++ L+ + A +E+++ + G Sbjct: 282 PDIAGKNIANPVASILSCIMMLKH-LNQTETAGIMEKSVENVIRNG 326 >UniRef50_A9QPI0 Isocitrate/isopropylmalate dehydrogenase n=3 Tax=Bacteria RepID=A9QPI0_METI4 Length = 482 Score = 136 bits (343), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 110/348 (31%), Positives = 172/348 (49%), Gaps = 39/348 (11%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKV-LDAVRNRFAMRITTSHYDVGGAAIDNHGQP--LPP 59 K I V GDGIGPE+M LKV L+A +I G + + G P + P Sbjct: 2 KKVPITVAYGDGIGPEIMDATLKVILEAGAELEIEKIEI------GFKVYSMGNPSGIEP 55 Query: 60 ATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGAL----LPLRKHFKLFSNLRPAKLYQ 115 ++ E ++ L P P+ G + +RK L++N+RP Y Sbjct: 56 SSWESLKRTKVFL-----------KAPITTPQGGGFKSLNVTVRKALGLYANIRPCISY- 103 Query: 116 GLEAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERI 175 P G D++ +RE +Y G + R+G ++ ++ R ERI Sbjct: 104 -----APF-IHTKHPGIDLVIIRENEEDLY-GGIEHRQGVDSFQA---LKIMTRQGTERI 153 Query: 176 ARIAFESAR-KRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQL 233 R AFE AR R KV+S K N+L+ + ++ ++ E+A EYP +E H ID + +L Sbjct: 154 IRYAFEYARCYGRKKVSSFTKDNILKITDGMFHKVFEEVAKEYPQIEKEHWIIDIGSAKL 213 Query: 234 IKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGK 293 +P FDVL+ +NL+GDILSD I GS+G+ SA++ + + ++E GSAP AG+ Sbjct: 214 ADNPQSFDVLVLANLYGDILSDVAVQIAGSVGLGASANIGHE-YSMFEAIHGSAPRRAGQ 272 Query: 294 NIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLAR 341 N+ANP +L+ +L + + + A + A + +EEGI T D+ R Sbjct: 273 NVANPSGLLLAAVQMLIH-IGQNAVADRVYNAWLKTIEEGIHTYDIFR 319 >UniRef50_B8FQF2 Isocitrate/isopropylmalate dehydrogenase n=2 Tax=Desulfitobacterium hafniense RepID=B8FQF2_DESHD Length = 374 Score = 136 bits (342), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 119/371 (32%), Positives = 168/371 (45%), Gaps = 38/371 (10%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFA-MRITTSHYDVGGAAIDNHGQPLPPAT 61 K Y IAV+P DG+G +V+ K + + + +Y+ G G+ Sbjct: 2 KKYTIAVIPLDGVGKDVIPLGAKAMQKAQEILGGFELDCRYYEAGVEYAVKTGKMCEDNL 61 Query: 62 VEGCEQADAVLFGSVGG-----PKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQG 116 E +ADA+L GS G K E+ P + L LR LRP +L +G Sbjct: 62 GEDIAKADAMLCGSAGHYDADMSKSEY--PGYKTGMQVLQFLRSGMGNSIGLRPLRLRKG 119 Query: 117 LEAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIA 176 ++ CPLR D+L VR+L G Y +P G + A+DT V R E+ A Sbjct: 120 ID--CPLRN---REEIDVLLVRQLAEGFYI-RPGHMIGE---DAAYDTIVVTRNVTEKFA 170 Query: 177 RIAFESARKR-------RHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNA 229 F AR R + VT +K + +R+I E++ YPD+ L +D Sbjct: 171 DTCFRLARGRHGRRQDGKKMVTLGNKHGNVTCFDFYRKIFTEVSAGYPDIGLQFTQVDAL 230 Query: 230 TMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGL---YEPAGGS 286 LIKDP +FDV+ C N+ GDI+ D A ITG MG+ P+A + G+ + P G+ Sbjct: 231 AEHLIKDPDRFDVIACENMIGDIIGDIGAYITGGMGITPTADVG----GVTPQFRPNHGT 286 Query: 287 APDIAGKNIANPIAQILSLALLL------RYSLDADDAACAIERAINRALEE-GIRTGDL 339 P GK ANP+A IL+ LLL R + A IE+A+ L G RT DL Sbjct: 287 FPRAVGKGFANPLASILTAGLLLDTLGNERGDDNLRRGARLIEKAVEYNLTTGGPRTKDL 346 Query: 340 ARGAAAVSTDE 350 A +T E Sbjct: 347 GGTANTFATAE 357 >UniRef50_A4FEJ6 3-isopropylmalate dehydrogenase n=1 Tax=Saccharopolyspora erythraea NRRL 2338 RepID=A4FEJ6_SACEN Length = 407 Score = 135 bits (340), Expect = 2e-30, Method: Compositional matrix adjust. Identities = 100/259 (38%), Positives = 133/259 (51%), Gaps = 22/259 (8%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNR-FAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 IAV+PGDGIGPE++ A++VL A R +R T+ D G A G + AT+E Sbjct: 9 IAVIPGDGIGPELVRSAVEVLRAAAGRDVELRFTSE--DAGADAFRRTGSAMSAATLERI 66 Query: 66 E-QADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 + VL G VG P H PD LR ++N+RP L G++A PLR Sbjct: 67 RTRYHGVLKGPVGLPGVRH--PDGTEAGLLGGVLRGGLDTYANVRPIALLPGVDA--PLR 122 Query: 125 ADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESAR 184 D + VRE T G+Y +GR G G D + R +ER+ AFE A Sbjct: 123 G----TAVDYVIVRENTEGLYLS--RGR-GVGNDRACADQLLMTRHGVERVVVHAFELAT 175 Query: 185 KRR-------HKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDP 237 +R +VT +DK+NVL+S +RE+ +E+AT YP VE H Y D A L+ DP Sbjct: 176 RRTGAPADGVRRVTCVDKSNVLRSFAFFREVFDEVATRYPQVEADHRYADAAGHDLVADP 235 Query: 238 SQFDVLLCSNLFGDILSDE 256 +FDVL+ N GDILSD Sbjct: 236 GRFDVLVMENFLGDILSDR 254 >UniRef50_P28241 Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial n=34 Tax=cellular organisms RepID=IDH2_YEAST Length = 369 Score = 134 bits (336), Expect = 7e-30, Method: Compositional matrix adjust. Identities = 112/354 (31%), Positives = 173/354 (48%), Gaps = 35/354 (9%) Query: 5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEG 64 Y ++ + GDGIGPE+ K+ A + I DV + N +P V+ Sbjct: 37 YTVSFIEGDGIGPEISKSVKKIFSAAN----VPIEWESCDVSPIFV-NGLTTIPDPAVQS 91 Query: 65 CEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 + L G + P + R L LRK F LF+N+RPAK +G + Sbjct: 92 ITKNLVALKGPLATPIGKG-------HRSLNLTLRKTFGLFANVRPAKSIEGFKT----- 139 Query: 125 ADIAANGFDILCVRELTGGIYFG-QPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 D++ +RE T G Y G + G Q K + R ER+ R AFE A Sbjct: 140 ---TYENVDLVLIRENTEGEYSGIEHIVCPGVVQSIK-----LITRDASERVIRYAFEYA 191 Query: 184 RK-RRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFD 241 R R +V + K+ + + + L+ + E++ EYPD+ L IDN+ ++++ +PS + Sbjct: 192 RAIGRPRVIVVHKSTIQRLADGLFVNVAKELSKEYPDLTLETELIDNSVLKVVTNPSAYT 251 Query: 242 --VLLCSNLFGDILSD-ECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANP 298 V +C NL+GDILSD + GS+G+ PSA++ + ++E GSAPDIAG++ ANP Sbjct: 252 DAVSVCPNLYGDILSDLNSGLSAGSLGLTPSANIGHK-ISIFEAVHGSAPDIAGQDKANP 310 Query: 299 IAQILSLALLLRYSLDADDAACAIERAINRALEEGI--RTGDLARGAAAVSTDE 350 A +LS ++L + + + A I+ A+ + G RTGDLA A S E Sbjct: 311 TALLLSSVMMLNH-MGLTNHADQIQNAVLSTIASGPENRTGDLAGTATTSSFTE 363 >UniRef50_C9SEZ4 Homoisocitrate dehydrogenase n=1 Tax=Verticillium albo-atrum VaMs.102 RepID=C9SEZ4_VERA1 Length = 316 Score = 133 bits (335), Expect = 8e-30, Method: Compositional matrix adjust. Identities = 117/361 (32%), Positives = 180/361 (49%), Gaps = 55/361 (15%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATV 62 + I ++PGDGIG EV+ ++L+A+ + ++ + G + G LP TV Sbjct: 4 RTLRIGLIPGDGIGKEVIPAGRRILEALPSYLGLKFEFTDLHAGFETFERTGAALPDKTV 63 Query: 63 EGCE-QADAVLFGSVGGPKWEHLPPDQQPERG---ALLPLRKHFKLFSNLRPAKLYQGLE 118 E + D LFG+V P P +G ++ LRK L++N+RP K Sbjct: 64 EILRNECDGALFGAVSSP--------SSPVKGYSSPIVALRKKLDLYANVRPVKTVLS-- 113 Query: 119 AFCPLRADIAANGFDILCVRELTGGIYFGQPKGREG-SGQYEKAFDTEVYHRFEIERIAR 177 AA D++ VRE T +Y + R+ G+ +A + R RIA Sbjct: 114 ---------AAKPIDMVIVRENTEDLYVKEETTRDTPDGKVAEAIK-RISERAS-HRIAT 162 Query: 178 IAFESARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDP 237 +A + A RR K+ + ++ QS P V + H N ++L Sbjct: 163 MAGDIAL-RRQKIRAAGAPSIHQS---------------PLVTITHK--SNVLLRL---- 200 Query: 238 SQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIAN 297 +V++ NL+GDILSD+ A + GS+G++PSA++ E GF + EP GSAPDI G+NIAN Sbjct: 201 --KNVIVDPNLYGDILSDDAAALVGSLGLVPSANVGE-GFAIGEPCHGSAPDIMGQNIAN 257 Query: 298 PIAQILSLALLLRYSLDADDAACAIERAINRALEEG-IRTGDLARGAAAVSTDEMGDIIA 356 PIA + S AL+L + LD + AA I A++ L EG + + DL G A +T+ + DI+ Sbjct: 258 PIATLRSAALMLEF-LDEEAAAAKIYAAVDANLTEGKLLSPDL--GGTAKTTEVIEDILR 314 Query: 357 R 357 R Sbjct: 315 R 315 >UniRef50_C6V444 Isocitrate dehydrogenase n=2 Tax=Neorickettsia RepID=C6V444_NEORI Length = 471 Score = 132 bits (332), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 104/341 (30%), Positives = 174/341 (51%), Gaps = 40/341 (11%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQP--LPPATVEG 64 + V GDG+GPE+MT L+++ ++I T G I G P + + E Sbjct: 4 LTVAYGDGVGPEIMTSVLEII--FEAGAEIQIDTIEI---GQKIYEKGWPSGISDSGWET 58 Query: 65 CEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 ++ +L + P+ + R + LRK LF+N+RP K + LE P Sbjct: 59 LKRNKVLLKAPITTPRGGGV-------RSLNVTLRKKLGLFANIRPCKSH--LEWQDP-- 107 Query: 125 ADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDT----EVYHRFEIERIARIAF 180 DI+ +RE +Y G +Y + DT +V ERI R AF Sbjct: 108 ------KMDIVIIRENEEDLYSGI--------EYRQTLDTYNCTKVITESTSERICRYAF 153 Query: 181 ESARKR-RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPS 238 E AR R KVT + K N+++ + ++ ++ ++A EYPD+E + ID ++ K+P Sbjct: 154 EYARSNGRKKVTVMVKDNIMKLTDGIFHKLFKKVALEYPDIESENYIIDIGAARIAKNPE 213 Query: 239 QFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANP 298 +FDV++ NL+GDI+SD A I+GS+G+ S ++ E+ + ++E GSAPDIA ++IANP Sbjct: 214 KFDVIVTLNLYGDIISDIAAEISGSVGLGGSINIGEE-YAMFEAVHGSAPDIADQDIANP 272 Query: 299 IAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDL 339 + +L+ A+ + + + A + A + L+ G+ T D+ Sbjct: 273 -SGLLNAAMYMLSYIGQKEIAQKVYSAWLKTLKSGVHTADI 312 >UniRef50_UPI000185C11E 3-isopropylmalate dehydrogenase n=1 Tax=Corynebacterium amycolatum SK46 RepID=UPI000185C11E Length = 394 Score = 128 bits (322), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 105/330 (31%), Positives = 150/330 (45%), Gaps = 34/330 (10%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCE 66 I +LPGDGIGPE+ ++ V + + T +G + HG P+P T E Sbjct: 17 ITLLPGDGIGPEITDACRGLIADVFPHWELTET----QIGWSQWRAHGNPVPQETWETLG 72 Query: 67 QADAVLFGSVGGPKWEHLPPDQQPE--------RGALLPLRKHFKLFSNLRPAKLYQGLE 118 ++DA L ++ + P R +L LR+ LF+N+RP L Sbjct: 73 RSDAALLAAITSKPAREAEEELAPHLRGTGLNYRSPVLQLRQRLDLFANIRPVTLPGAAA 132 Query: 119 AFCPLRADIAA-NGFDILCV----------RELTGGIYFGQPKGREGSGQYEKAFDTEVY 167 F +R + D L L + R + E A V Sbjct: 133 DFTIVRENTEGLYSHDYLLPPHDAPADSPHHHLWAEVVEDSTVARAVDKRGEVAVSLRVT 192 Query: 168 HRFEIERIARIAFESARKRRH---------KVTSIDKANVLQSSI-LWREIVNEIATEYP 217 F R+AR A + A R+ VT DK N+L+ S + R V E+A EYP Sbjct: 193 TSFAWHRLARQAAKLALARQAANPDSEVTPTVTVADKPNILRDSARVIRGAVEEVAEEYP 252 Query: 218 DVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGF 277 V D MQL+ DP++FDV++ NL GDILSD A + G +G+ SA++ + F Sbjct: 253 QVAFDFANADAVAMQLVTDPARFDVIIAENLIGDILSDIGAGLIGGLGLAASANVGDN-F 311 Query: 278 GLYEPAGGSAPDIAGKNIANPIAQILSLAL 307 ++EP GSAPDIAG+ IANP A +LS A+ Sbjct: 312 AVFEPVHGSAPDIAGRGIANPAAFLLSAAM 341 >UniRef50_A9UQS3 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UQS3_MONBE Length = 378 Score = 128 bits (321), Expect = 4e-28, Method: Compositional matrix adjust. Identities = 108/355 (30%), Positives = 172/355 (48%), Gaps = 51/355 (14%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPAT 61 ++ + + GDGIG E+++ A + ++A + I D+G A+ N G + + Sbjct: 31 TQAHTVLTFDGDGIGREIVSAAKECIEAT----GVNIRWEQMDMGYEAMQNTGVYIDDSH 86 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPE---RGALLP-----LRKHFKLFSNLRPAKL 113 ++ E+ + G + P P D RG RK+F+LF+N+RP + Sbjct: 87 MDAFEEIGVLFKGPLTVP-----PKDTNAYVEVRGKRYTSGNQVFRKYFQLFANVRPVRS 141 Query: 114 YQGLEAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYH----- 168 G+ A P N D++ +RE T +Y G+ E D + H Sbjct: 142 MPGVRA--PF------NDVDLVVIRENTEDVYTGE----------ETWVDADTVHCVKRI 183 Query: 169 -RFEIERIARIAFESAR-KRRHKVTSIDKANVL-QSSILWREIVNE--IATEYPDVELAH 223 R ER+A +F+ AR +R +VT++ KANV QS L+ +E AT+ + Sbjct: 184 SRGASERVADFSFKYARDNQRKRVTALHKANVCKQSDGLFLNTFHERAAATDLGGIIADD 243 Query: 224 MYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMIT----GSMGMLPSASLNEQGFGL 279 D+ +L+ +P FDVL C NL+GD+++ I GS+G+ PS ++ L Sbjct: 244 QLADSCLTKLMIEPKSFDVLCCPNLYGDLVNPLSLRINRGMVGSLGLCPSGNIGTHQ-AL 302 Query: 280 YEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGI 334 +EPA GSAPDIAGK IANP +QILS ++L + L +A+ +E A+ GI Sbjct: 303 FEPAHGSAPDIAGKGIANPTSQILSGCMMLSH-LGEFEASQRLENALRAMYASGI 356 >UniRef50_C1F3J9 Isocitrate dehydrogenase n=1 Tax=Acidobacterium capsulatum ATCC 51196 RepID=C1F3J9_ACIC5 Length = 502 Score = 127 bits (318), Expect = 9e-28, Method: Compositional matrix adjust. Identities = 99/337 (29%), Positives = 166/337 (49%), Gaps = 28/337 (8%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAA-IDNHGQPLPPATVEGC 65 + V GDGIGPE+ + +L A + + +VG + + +P + Sbjct: 24 VTVAAGDGIGPEITAAVMSILSAA----GAHLDAEYVEVGEQVYLRGNTSGIPQEAWDSI 79 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 + +L G + P+ + + +RK L++N+RP + Y+ + Sbjct: 80 ARTRVMLKGPITTPQGGGY-------KSLNVTMRKTLGLYANVRPCRTYKPI--VTTRHP 130 Query: 126 DIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARK 185 D+ D++ VRE +Y G E + A ++ R ERIAR AFE AR+ Sbjct: 131 DM-----DVVIVRENEEDLY----AGIEHRQTQDVAQCLKLITRSGSERIARYAFEYARQ 181 Query: 186 R-RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVL 243 R K+T + K N+++ + L+ + +E+A EYP+++ +D + P +DV+ Sbjct: 182 HGRSKITCMIKDNIMKLTDGLFHRVFDEVAREYPEIQAHSQIVDFGMANFVHRPEDYDVV 241 Query: 244 LCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQIL 303 L NL+GDILSD A +TGS+G+ S ++ G ++E GSAPD+A +++ANP +L Sbjct: 242 LLPNLYGDILSDIAAQMTGSVGLGGSVNIGSGG-AIFEAIHGSAPDLA-RDVANPSGLLL 299 Query: 304 SLALLLRYSLDADDAACAIERAINRALEEGIRTGDLA 340 + +LR+ L D A + A LEEGI T D+A Sbjct: 300 AAVEMLRH-LKLDSIAAKVMNAWLCTLEEGIHTVDIA 335 >UniRef50_Q0ZQ44 FrbE n=1 Tax=Streptomyces rubellomurinus RepID=Q0ZQ44_9ACTO Length = 365 Score = 125 bits (314), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 100/352 (28%), Positives = 161/352 (45%), Gaps = 43/352 (12%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATV 62 + + + ++ GDG GPE++ A VLD + G A+ + G+ LP +T+ Sbjct: 2 RKHTVTLIAGDGSGPELVAAARTVLDTAAGSAGFHLDWDVRPAGQGALRSVGELLPASTL 61 Query: 63 EGCEQADAVLFGSVGGPKWEHLPPDQQP----ERGALLPLRKHFKLFSNLRPAKLYQGLE 118 + + L G P P R + +R+ L++ +RP +++ G Sbjct: 62 DSIRRNGVALKG-----------PTTTPIGVGHRSVNITIRRELDLYACVRPVRVWPG-- 108 Query: 119 AFCPLRADIAANGFDILCVRELTGGIYFG--QPKGREGSGQYEKAFDTEVYHR-----FE 171 A +G D++ VRE T +Y G P +G+ +E H F Sbjct: 109 ------AGAVDSGIDVVVVRENTEDVYSGLEYPADSDGAAVVSATL-SEFGHADPGIAFS 161 Query: 172 IE--------RIARIAFESARK--RRHKVTSIDKANVLQSSILWREIVNEIATEYPDVEL 221 ++ RI A + ARK RR D ++ L+ E E+ EYPD+ Sbjct: 162 LKPITPGGSRRIVAFALDHARKNGRRKVEVGADVYRYPRTEGLFFEAARELGPEYPDIVT 221 Query: 222 AHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYE 281 A + + L++DP+ DVL+ NL+GD++SD A + G +GM P A++ ++ ++E Sbjct: 222 ATVPVTVLCDSLVRDPADRDVLVLPNLYGDVISDVTAALVGGLGMAPGANIGDR-TAVFE 280 Query: 282 PAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEG 333 GSAP+ AG N NP A ILS +LL + +A AA I A+ LEEG Sbjct: 281 ATHGSAPEFAGSNRLNPTALILSGCMLLDHLGEAPTAA-RIRAAVRSVLEEG 331 >UniRef50_Q6L0K7 3-isopropylmalate dehydrogenase n=1 Tax=Picrophilus torridus RepID=Q6L0K7_PICTO Length = 335 Score = 125 bits (314), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 89/308 (28%), Positives = 152/308 (49%), Gaps = 19/308 (6%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCE 66 +A++PGDGIG E+M + ++ + I +D+ G + +E + Sbjct: 4 VALIPGDGIGREIMPGVAAAISSISD-----INFVTFDISSERYIKTGIIIKDDELEELK 58 Query: 67 QADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRAD 126 A+LFG++G P+ + P E+G +L LR+ +L+ N+RP + + LR + Sbjct: 59 NYRAILFGAIGDPR---VRPGIM-EQGVILRLRRELELYMNIRPVRSFDDKIKITILREN 114 Query: 127 IAANGFDILCVRELTGGIYFGQPKGR---EGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 DI + + G F R +GS E + + +++ AF Sbjct: 115 TQDFYTDISGI--IPGKRSFNVNGTRIEIDGSSCDEVYYTMGMLSYRYLKKFFNKAFSIC 172 Query: 184 RKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVL 243 VT DKAN ++ LWR E A E ++ ++ Y D +I +P ++ + Sbjct: 173 ---DSTVTVTDKANAVKMYNLWRSTAMEAAIE-KNINISFEYADALAYNMILNPKKYRYI 228 Query: 244 LCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQIL 303 + NL+GDI+SD A + G +G PSA++ ++ L+EP GSAPDIAG+++ANP A I+ Sbjct: 229 IAPNLYGDIISDMGAALVGGLGYAPSANIGDKN-ALFEPVHGSAPDIAGRDMANPAASIM 287 Query: 304 SLALLLRY 311 + ++LL Y Sbjct: 288 AGSMLLEY 295 >UniRef50_Q48806 Protein dlpA n=5 Tax=Legionella RepID=DLPA_LEGPH Length = 615 Score = 125 bits (313), Expect = 3e-27, Method: Compositional matrix adjust. Identities = 112/374 (29%), Positives = 173/374 (46%), Gaps = 44/374 (11%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCE 66 IAVLPGDGIG EV L V + + + + ++ D+G G +P T + Sbjct: 9 IAVLPGDGIGIEVTEATLPVFEVLD----VPVILNYGDIGWEFWKKEGAAIPSRTWQLIA 64 Query: 67 QADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSN---LRPA-KLYQGLEAFCP 122 +D VL G++ +P+R A L K SN + P +L QGL+ F Sbjct: 65 SSDTVLLGAI----------TSKPQREAKQELSNALKK-SNPYYVSPVIQLRQGLDLFAN 113 Query: 123 LRA----DIAANGFDILCVRELTGGIY-----FGQPKGREGSGQYEKAFDT--------- 164 +R D + F+ +RE + G+Y F PK + + T Sbjct: 114 VRPCFSIDDQSKPFNFCIIRENSEGLYCGFDYFPLPKAIHSLLAESQHWQTIPADEASCA 173 Query: 165 -EVYHRFEIERIARIAFESARKR-RHKVTSIDKANVL-QSSILWREIVNEIATEYPDVEL 221 + + + R+ AF+ A + +VT DK NVL +S R+I A YP ++ Sbjct: 174 LRLQSKSGLTRLFDFAFKHAMQTGMPRVTLADKPNVLRESGEFTRKIFESTAQRYPKIQA 233 Query: 222 AHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYE 281 + +D + LIK P +F V++ N+FGDILSD A + G +G+ PSA++ ++G +E Sbjct: 234 DILNVDAVALWLIKSPEKFGVIVAENMFGDILSDVGAGVMGGLGLAPSANIGDKG-SYFE 292 Query: 282 PAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLAR 341 P GS P I KN ANP A L++++LL + D A + + E+ T DL Sbjct: 293 PVHGSGPRIR-KNCANPSAMFLTISMLLNHFGYPDRAKKIVNAVMQVIKEKRFITYDL-- 349 Query: 342 GAAAVSTDEMGDII 355 G A +TD +I Sbjct: 350 GGHATTTDMANAVI 363 >UniRef50_Q5P9Q1 Isocitrate dehydrogenase n=13 Tax=Rickettsiales RepID=Q5P9Q1_ANAMM Length = 488 Score = 123 bits (309), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 94/337 (27%), Positives = 163/337 (48%), Gaps = 29/337 (8%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQP-LPPATVEGC 65 I V GDG+GPE+M L +L R ++ D+G + P+ E Sbjct: 10 ITVAYGDGVGPEIMEAVLFILKEARADVSIETV----DIGHNQYKKEWTSGIAPSAWESI 65 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 + +L K + P + + LR+ L+ N+RP ++ P+ Sbjct: 66 SRTRLLL-------KAPTMTPQGSGHKSLNVALRQRLGLYVNVRPCV------SYFPVVG 112 Query: 126 DIAANGFDILCVRELTGGIYFG-QPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESAR 184 + D++ +RE Y G + K E + + K + R E+I AF AR Sbjct: 113 TKHPD-LDVVIIRENEEDTYSGVEHKLSEDTHECVK-----ISTRSASEKICAYAFNYAR 166 Query: 185 -KRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDV 242 R KVT K N+++ + + +++A YPD+E + +D ++ +P FDV Sbjct: 167 AHNRKKVTCFVKDNIMKMTDGILHASFDKVAKGYPDIEANYYIVDVGMAKIASNPEDFDV 226 Query: 243 LLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQI 302 ++ +NL+GDI+SD ++ +GS+G+ SA++ + + ++E GSAPDIAGKN+ANP + + Sbjct: 227 VVTTNLYGDIVSDIVSLSSGSIGLTGSANIGDY-YAMFEAVHGSAPDIAGKNVANP-SGL 284 Query: 303 LSLALLLRYSLDADDAACAIERAINRALEEGIRTGDL 339 L+ A+ + + D A I A + LE+G+ T D+ Sbjct: 285 LNAAVQMLVHIGQLDKAGVIRNAFLKTLEDGVHTADI 321 >UniRef50_P96318 Isocitrate dehydrogenase [NADP] n=5 Tax=cellular organisms RepID=IDH_CALNO Length = 429 Score = 122 bits (307), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 115/401 (28%), Positives = 175/401 (43%), Gaps = 59/401 (14%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRF---AMRITTSHYDVGGAAIDNHGQPLPPA 60 N +A GDGIGPE++ A KVLDA ++ RI G A G LP Sbjct: 32 NLIVAYFKGDGIGPEIVESAKKVLDAAVDKAYGGTRRIVWWEVTAGEEAQKECGSLLPDG 91 Query: 61 TVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAF 120 T++ + A L G + P R + LR L+SN+RP K Y Sbjct: 92 TLQAFKLARVNLKGPLTTPVGGGF-------RSLNVTLRMVLDLYSNVRPVKWYGQPTPH 144 Query: 121 CPLRADIAANGFDILCVRELTGGIY------FGQPKGREGSGQYEKAFDTEV-------- 166 C D + RE T +Y F P+ ++ +K F E+ Sbjct: 145 C------HPENIDWVIFRENTEDVYAGIEWPFDSPEAQKIRDFLKKEFGIELTPDTGIGI 198 Query: 167 --YHRFEIERIARIAFESARKRRHK-VTSIDKANVLQSS-----------IL--WREIV- 209 ++ +R R A E A + +K VT + K N+++ + IL +R+ V Sbjct: 199 KPISKWRTQRHVRRAMEWAIRNGYKHVTIMHKGNIMKYTEGAFRQWAYDLILSEFRDYVV 258 Query: 210 --NEIATEY----PD--VELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMIT 261 E+ T+Y P+ + + DN Q+I P +++V++ NL GD +SDE + Sbjct: 259 TEEEVNTKYGGKAPEGKIIVNDRIADNMLQQIITRPGEYNVIVTPNLNGDYISDEANALV 318 Query: 262 GSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACA 321 G +GM + + G + EP GSAP AGKN+ NP A+ILS LL + + Sbjct: 319 GGIGMAAGLDMGD-GIAVAEPVHGSAPKYAGKNVINPTAEILSGMYLLSDFVGWPEVKLL 377 Query: 322 IERAINRALEEGIRTGDLAR---GAAAVSTDEMGDIIARYV 359 +E A+ +A+ T DLAR G +ST E D++ Y+ Sbjct: 378 VEYAVKQAIAHKQVTYDLAREMGGVTPISTTEYTDVLVDYI 418 >UniRef50_A4WLX6 Isocitrate dehydrogenase (NADP) n=22 Tax=Archaea RepID=A4WLX6_PYRAR Length = 439 Score = 119 bits (297), Expect = 2e-25, Method: Compositional matrix adjust. Identities = 112/377 (29%), Positives = 168/377 (44%), Gaps = 57/377 (15%) Query: 7 IAVLPGDGIGPEVMTQALKVL-DAVRNRF--AMRITTSHYDVGGAAIDNHGQPLPPATVE 63 I + GDGIGPEV A+KV +AV + + +IT VG A G LP ++E Sbjct: 47 IGYIEGDGIGPEVAYAAIKVANEAVEKAYGKSRQITWYEIVVGEKAEKLFGNRLPDQSIE 106 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 + L + P R + LR+ F L++N+RP K + GL + PL Sbjct: 107 VLRKIRVFLKAPLETPVGGGF-------RSINVTLRQLFDLYANIRPVKYFPGLPS--PL 157 Query: 124 RADIAANGFDILCVRELTGGIY------FGQPKGREGSGQYEKAFDTEV----------Y 167 R D++ RE T +Y + P+ + + F + Sbjct: 158 RR---PELVDLVIFRENTEDVYAGIEWPYNSPEAAKIREFLRREFGVNIRDDAGIGIKPI 214 Query: 168 HRFEIERIARIAFESA-RKRRHKVTSIDKANVLQ-SSILWREIVNEIATE-------YPD 218 +F +RIAR+A + A +R VT + K N+ + + ++E E+A + D Sbjct: 215 SKFGTQRIARLALKFAIENKRRVVTVMHKGNIQKYTEGAFKEWAFEVARNEFREHVVFED 274 Query: 219 VELAHM--------------YIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSM 264 ELA DN QL+ ++DV+L NL GD +SDE A + G + Sbjct: 275 -ELAQYGGSVPPGKVLVNDRIADNMLQQLLTRTGEYDVILAPNLNGDYVSDEAAGLVGGL 333 Query: 265 GMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIER 324 G+ P + + G + EP G+AP GKN NP A IL+L L+ R+ L + A I + Sbjct: 334 GVAPGLDVGDWGM-MAEPVHGTAPKYRGKNYVNPTATILALELMFRF-LGWREVAEYIMK 391 Query: 325 AINRALEEGIRTGDLAR 341 + A EG TGDLAR Sbjct: 392 GVETAYREGYFTGDLAR 408 >UniRef50_O43837 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial n=80 Tax=Eumetazoa RepID=IDH3B_HUMAN Length = 385 Score = 117 bits (294), Expect = 5e-25, Method: Compositional matrix adjust. Identities = 100/369 (27%), Positives = 177/369 (47%), Gaps = 42/369 (11%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 ++ + +LPGDG+GPE+M +V A A+ + + + + + N V Sbjct: 48 SFPVTMLPGDGVGPELMHAVKEVFKAA----AVPVEFQEHHL--SEVQNMASEEKLEQVL 101 Query: 64 GCEQADAV-LFGSVGGPKWEHLPPDQQPERGAL-LPLRKHFKLFSNLRPAKLYQGLEAFC 121 + + V + G + H P + + E + + LR+ LF+N+ K G Sbjct: 102 SSMKENKVAIIGKI------HTPMEYKGELASYDMRLRRKLDLFANVVHVKSLPGYMT-- 153 Query: 122 PLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDT----EVYHRFEIERIAR 177 N D++ +RE T G Y S ++E A ++ R + +RIA+ Sbjct: 154 ------RHNNLDLVIIREQTEGEY--------SSLEHESARGVIECLKIVTRAKSQRIAK 199 Query: 178 IAFESARKR-RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIK 235 AF+ A K+ R KVT++ KAN+++ L+ + E+A YP ++ M IDN MQL++ Sbjct: 200 FAFDYATKKGRGKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQ 259 Query: 236 DPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAP--DIAGK 293 +P QFDVL+ NL+G+I+ + A + G G++P S + + + ++E G P G+ Sbjct: 260 NPYQFDVLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAE-YAVFE-TGARHPFAQAVGR 317 Query: 294 NIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGD 353 NIANP A +LS + +LR+ ++ + +RT D+ G + +TD + Sbjct: 318 NIANPTAMLLSASNMLRHLNLEYHSSMIADAVKKVIKVGKVRTRDM--GGYSTTTDFIKS 375 Query: 354 IIARYVAEG 362 +I +G Sbjct: 376 VIGHLQTKG 384 >UniRef50_B7PN53 Isocitrate dehydrogenase, putative (Fragment) n=1 Tax=Ixodes scapularis RepID=B7PN53_IXOSC Length = 381 Score = 117 bits (292), Expect = 8e-25, Method: Compositional matrix adjust. Identities = 95/355 (26%), Positives = 169/355 (47%), Gaps = 33/355 (9%) Query: 5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEG 64 + + +LPG GIGPE+M + + +VG A+ +H ++ Sbjct: 48 FFVTLLPGHGIGPEMMRHVEAIFACGKVPVDFETIIVDANVGDASSMDHA-------IKS 100 Query: 65 CEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 + L G++ + + L LR +L+ N+ + + G+ Sbjct: 101 IRRNGVALKGNIETTSYSMTVEPRN------LLLRNKLELYVNVVHCRNHPGI------- 147 Query: 125 ADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESAR 184 + G DI+ +R+ T G Y + SG E F+I A+ FE AR Sbjct: 148 -NTKHKGVDIVVIRQNTEGEY-SCLEHEVTSGVVESLKIITWAKSFQI---AKYCFEYAR 202 Query: 185 KR-RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDV 242 R KVT + KAN+++ + L+ + E+A EYPD+EL + IDN MQL+ +P+QFDV Sbjct: 203 THMRKKVTVVHKANIMKLTDGLFLKTCTEVAQEYPDIELNDIIIDNCCMQLVANPAQFDV 262 Query: 243 LLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAG-GSAPDIAGKNIANPIAQ 301 +L NL+G+I+ + + G G+ + ++ + ++E A + + GKN+ANP+A Sbjct: 263 MLVPNLYGNIVVNVACGLVGGAGVTSGRNYGKE-YAVFETATRNTGTPLVGKNLANPVAT 321 Query: 302 ILSLALLLRYSLDADDAACAIERAINRALE-EGIRTGDLARGAAAVSTDEMGDII 355 + + +L++ L+ D A I RAI + + + + T DL G A ++ + +I+ Sbjct: 322 LYAAVDMLKH-LELWDHAVVIRRAIEKTVNRDKVHTKDL--GGDATTSKVVENIL 373 >UniRef50_C4QCG1 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial, putative n=1 Tax=Schistosoma mansoni RepID=C4QCG1_SCHMA Length = 399 Score = 116 bits (290), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 95/337 (28%), Positives = 157/337 (46%), Gaps = 31/337 (9%) Query: 5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEG 64 + +A+L GDG+GPE+++ +V + V GA ID + + E Sbjct: 69 HTVAMLLGDGVGPELLSYVKEV----------------FQVIGAPIDFEEVAVNQES-ED 111 Query: 65 CEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 DA+L G + + + + LR + L++ ++ + + G+ Sbjct: 112 ATFTDALLAMKRNGVGIKGNFATEPGQSSRNVALRLNLNLYAFVQRCRNFPGVVT----- 166 Query: 125 ADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA- 183 DI+ +RE T G Y + + G E ++ R + RIA+ AF+ A Sbjct: 167 ---RHQNVDIVIIRENTEGEY-SRLEHENVPGVVE---SLKIITREKSTRIAQFAFDYAV 219 Query: 184 RKRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDV 242 R R KVT++ KAN+++ L+ ++ + IA YP +E HM IDN MQL+ P QFDV Sbjct: 220 RHNRKKVTAVHKANIMKLGDGLFLDVCSSIAKNYPQIEFNHMIIDNTCMQLVTKPQQFDV 279 Query: 243 LLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQI 302 ++ NL+G+I+ + A + G G+ +L Q S +AGKNIANP + Sbjct: 280 IVLPNLYGNIVGNVAAGLVGGAGLTTGINLGPQNALFEMGTRNSGRSLAGKNIANPCGML 339 Query: 303 LSLALLLRYSLDADDAACAIERAINRALEEGIRTGDL 339 L+ A +L Y +A + ++ E+ IRT DL Sbjct: 340 LTSADMLEYLGHIKEAKLIRDSVVDVIGEQKIRTADL 376 >UniRef50_A7SJV9 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7SJV9_NEMVE Length = 394 Score = 116 bits (290), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 97/337 (28%), Positives = 164/337 (48%), Gaps = 26/337 (7%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCE 66 + ++PGDGIGPE++ + V D R+ + + ++ G I + L E Sbjct: 53 VTLIPGDGIGPEMV---VAVQDIFRH-IGVPVDFEELNLSGLDIKDEDSYLGAFN----E 104 Query: 67 QADAVLFGSVGGPKWEHLPPDQQPE-RGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 ++ V P D P R L LR H LF+N+ K G++ Sbjct: 105 AITSIKRNGVAMKGNIFTPLDAIPGFRSLNLELRVHLDLFANIVRCKSIPGIQT------ 158 Query: 126 DIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARK 185 N D++ +R+ T G Y + SG E + +V +IA+ AF+ A K Sbjct: 159 --RHNNVDLVIIRQNTEGEY-SHLEHENVSGVIE---NLKVTTEEACMKIAQYAFDFAEK 212 Query: 186 R-RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVL 243 R KVT++ KAN+++ L+ E++ YP++E M IDN MQL+ P QFDV+ Sbjct: 213 HDRKKVTAVHKANIMKMGDGLFLRCCEEMSHSYPNIEFNSMIIDNCCMQLVAHPQQFDVM 272 Query: 244 LCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAG-GSAPDIAGKNIANPIAQI 302 + NL+G+I+S+ A + G G++P ++ + ++E + DI GK+I+NPI+ + Sbjct: 273 VLPNLYGNIVSNIGASLVGGPGIVPGENIGGD-YAIFESGSRHTGLDIQGKDISNPISML 331 Query: 303 LSLALLLRYSLDADDAACAIERAINRALEEGIRTGDL 339 + L+L + L+ A I AI + ++ G+ T D+ Sbjct: 332 FASTLMLEH-LEFTAYADLINSAILKVVQRGVLTADV 367 >UniRef50_A0D2B8 Chromosome undetermined scaffold_35, whole genome shotgun sequence n=4 Tax=Oligohymenophorea RepID=A0D2B8_PARTE Length = 355 Score = 115 bits (289), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 101/355 (28%), Positives = 166/355 (46%), Gaps = 40/355 (11%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 ++ ++PG GIGPE+ V +A+ H + +DN + + Sbjct: 34 NVTLIPGVGIGPEITNSVKTVFEAL-----------HVPIKFDVLDNFNFENDDSKSQ-L 81 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 + + +L G + ++ + K+ L+SN+ A +G+ Sbjct: 82 RKNECILLG---------VMTEKNQKYTDNYKFYKYLDLYSNITFAFSVEGITQ------ 126 Query: 126 DIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESAR- 184 N DI+ +RE T G Y G + G E +V + RIA AFE A Sbjct: 127 --RHNNTDIVVIRENTEGEYSG-VEHEVYPGVVE---SIKVTTKQASLRIAEYAFEFAHL 180 Query: 185 KRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVL 243 R KVT++ KAN+++ L+ + E+A Y ++ M IDN MQL+K+P+QFDV+ Sbjct: 181 SGRRKVTAVHKANIMKLVDGLFLQACREVAQRYSFIKYEEMIIDNCCMQLVKNPTQFDVM 240 Query: 244 LCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQIL 303 + NL+G I+ + A ITG +GM AS+ + + + DIAGKN+ NP A ++ Sbjct: 241 VMPNLYGSIVQNVVAGITGGVGMAAGASIGKDHALFSQGCRHTGRDIAGKNVVNPSAMLV 300 Query: 304 SLALLLRYSLDADDAACAIERAINRALEE-GIRTGDLARGAAAVSTDEMGDIIAR 357 S LLLR+ L + A I RA+ +++ I+T D+ A +TD+ + R Sbjct: 301 SSTLLLRH-LGLPNFADQICRAVQHTIQDKKIKTKDIGGNA---TTDQFTSEVIR 351 >UniRef50_P41564 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (Fragment) n=17 Tax=Bilateria RepID=IDH3G_MACFA Length = 355 Score = 115 bits (289), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 99/355 (27%), Positives = 174/355 (49%), Gaps = 33/355 (9%) Query: 5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEG 64 + + ++PGDGIGPE+M V++ F ++ + + + + A + Sbjct: 17 HTVTMIPGDGIGPELMLH-------VKSVFRHACVPVDFEEVHVSSNADEEDIRNA-IMA 68 Query: 65 CEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 + L G++ +LPP + L R L++N+ K L Sbjct: 69 IRRNRVALKGNI--ETNHNLPPSHKSRNNIL---RTSLDLYANVIHCK---SLPGVVTRH 120 Query: 125 ADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESAR 184 DI DIL VRE T G Y + +G E ++ + + RIA AF+ A+ Sbjct: 121 KDI-----DILIVRENTEGEY-SSLEHESVAGVVE---SLKIITKAKSLRIAEYAFKLAQ 171 Query: 185 KR-RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDV 242 + R KVT++ KAN+++ L+ + E+A YP + +M +DN TMQL+ P QFDV Sbjct: 172 ESGRKKVTAVHKANIMKLGDGLFLQCCREVAARYPQITFENMIVDNTTMQLVSRPQQFDV 231 Query: 243 LLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAG-GSAPDIAGKNIANPIAQ 301 ++ NL+G+I+++ CA + G G++ A+ + ++E A + IA KNIANP A Sbjct: 232 MVMPNLYGNIVNNVCAGLVGGPGLVAGANYGHV-YAVFETATRNTGKSIANKNIANPTAT 290 Query: 302 ILSLALLLRYSLDADDAACAIERAINRALE-EGIRTGDLARGAAAVSTDEMGDII 355 +L+ ++L + L A +I +A+ +++ E + T D+ G +++ + DII Sbjct: 291 LLASCMMLDH-LKLHSYATSIRKAVLASMDNENMHTPDI--GGQGTTSEAIQDII 342 >UniRef50_P51553 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial n=41 Tax=Euteleostomi RepID=IDH3G_HUMAN Length = 393 Score = 115 bits (287), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 98/355 (27%), Positives = 174/355 (49%), Gaps = 33/355 (9%) Query: 5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEG 64 + + ++PGDGIGPE+M V++ F ++ + + + + A + Sbjct: 55 HTVTMIPGDGIGPELMLH-------VKSVFRHACVPVDFEEVHVSSNADEEDIRNA-IMA 106 Query: 65 CEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 + L G++ +LPP + L R L++N+ K L Sbjct: 107 IRRNRVALKGNI--ETNHNLPPSHKSRNNIL---RTSLDLYANVIHCK---SLPGVVTRH 158 Query: 125 ADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESAR 184 DI DIL VRE T G Y + +G E ++ + + RIA AF+ A+ Sbjct: 159 KDI-----DILIVRENTEGEY-SSLEHESVAGVVE---SLKIITKAKSLRIAEYAFKLAQ 209 Query: 185 KR-RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDV 242 + R KVT++ KAN+++ L+ + E+A YP + +M +DN TMQL+ P QFDV Sbjct: 210 ESGRKKVTAVHKANIMKLGDGLFLQCCREVAARYPQITFENMIVDNTTMQLVSRPQQFDV 269 Query: 243 LLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAG-GSAPDIAGKNIANPIAQ 301 ++ NL+G+I+++ CA + G G++ A+ + ++E A + IA KNIANP A Sbjct: 270 MVMPNLYGNIVNNVCAGLVGGPGLVAGANYGHV-YAVFETATRNTGKSIANKNIANPTAT 328 Query: 302 ILSLALLLRYSLDADDAACAIERAINRALE-EGIRTGDLARGAAAVSTDEMGDII 355 +L+ ++L + L A +I +A+ +++ E + T D+ G +++ + D+I Sbjct: 329 LLASCMMLDH-LKLHSYATSIRKAVLASMDNENMHTPDI--GGQGTTSEAIQDVI 380 >UniRef50_C5GTE7 Tartrate dehydrogenase n=2 Tax=Ajellomyces dermatitidis RepID=C5GTE7_AJEDR Length = 307 Score = 114 bits (286), Expect = 4e-24, Method: Compositional matrix adjust. Identities = 95/310 (30%), Positives = 152/310 (49%), Gaps = 48/310 (15%) Query: 5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITT--SHYDVGGAAIDNHGQPLPPATV 62 Y IA + GDGIGPEV+ NR A + S G I + + P + Sbjct: 16 YKIAAIRGDGIGPEVIEAGNYQSAEETNRVAWILLNWPSRTLSGAVRITRNTADISPIS- 74 Query: 63 EGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 + + F S LPLR SN+ P +++ G+++ P Sbjct: 75 ----SSTFLWFSS-------------------YLPLRSST---SNM-PTRVFHGIQS--P 105 Query: 123 LRADIAANGFDILCVRELTGGIYFGQPKGREGSGQ-YEKAFDTEVYHRFEIERIARIAFE 181 L D + VRE + G Y G GR +G+ +E A D ++ R +ERI + AFE Sbjct: 106 LH-------LDWVIVRENSEGEYAGH-GGRSYAGKPWEVATDISIFTRHGVERIMKFAFE 157 Query: 182 SARKRRHK-VTSIDKANVLQSS-ILWREIVN-EIATEYPDVELAHMYIDNATMQLIKDPS 238 +AR R K +T K+N ++ ++W EI E+A ++PDV M +D T +++ P Sbjct: 158 AARSRAKKHITVATKSNAQRNGLVVWDEIAAAEVAAQFPDVTCDKMLVDAMTARVVLTPE 217 Query: 239 QFDVLLCSNLFGDILSDECAMITGSMGMLPSASLN--EQGFGLYEPAGGSAPDIAGKNIA 296 D ++ +NL ILSD + + GS+G+ P+++L+ + ++EP GSA DIAGK++A Sbjct: 218 SLDTIVPTNLHAGILSDLASALAGSIGIAPTSNLDPTRENPSMFEPVHGSAFDIAGKDLA 277 Query: 297 N--PIAQILS 304 +A++LS Sbjct: 278 TFWTVAEMLS 287 >UniRef50_O67480 Isocitrate dehydrogenase [NADP] n=5 Tax=Aquificales RepID=IDH_AQUAE Length = 426 Score = 114 bits (284), Expect = 6e-24, Method: Compositional matrix adjust. Identities = 113/404 (27%), Positives = 185/404 (45%), Gaps = 64/404 (15%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLD-AVRNRF--AMRITTSHYDVGGAAIDNHGQPLPPA 60 N I + GDGIGPE+ L +++ AV + + +I G A + G+ LP Sbjct: 38 NPIIPFIEGDGIGPEITQAMLLIINTAVEKTYNGSKKIYWVELLAGDKAEEKTGERLPQE 97 Query: 61 TVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAF 120 T++ +++ + G +G P + + R LR+ F +S +RP + G Sbjct: 98 TLDVLKESIVGIKGPLGTPVGKGV-------RSINSALRRAFDYYSAVRPV-YWMGQATP 149 Query: 121 CPLRADIAANGFDILCVRELTGGIYFG------QPKGRE-------GSGQYEKAFDTEV- 166 P + D++ RE T +Y G P+ ++ G E+ F +V Sbjct: 150 IPNPERV-----DLVVFRENTDDVYAGVEFFAGTPEAKKVREFLIKEMGAKEEGFPEDVG 204 Query: 167 -----YHRFEIERIARIAFESARKRRHK-VTSIDKANVLQSS----ILWR-------EIV 209 F+ +R R A A + K V I K N+++++ I W E Sbjct: 205 ITVKPMSEFKTKRHVRKALRYALENNKKNVAVIGKGNIMKATEGAFINWAFEVAEEPEFK 264 Query: 210 NEIATEYPD-------VELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITG 262 ++ T+ P+ V+L + D MQL+ P +DV++ NL GD +SD A + G Sbjct: 265 GKVVTD-PEAEPGEGQVKLTKVITDQMLMQLVLKPEAWDVIIAQNLNGDYVSDLAASLIG 323 Query: 263 SMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAI 322 G +PS ++ + G+ L+E G+A DIAGK IANP++ LS A++L Y + +AA + Sbjct: 324 GPGFVPSGNIGD-GYALFESTHGTAWDIAGKGIANPLSLTLSGAMMLEY-IGWKEAAQKV 381 Query: 323 ERAINRALEEGIRTGDLARG-------AAAVSTDEMGDIIARYV 359 A+ R L E I T D+A G A AV T E + I++ + Sbjct: 382 YDAVRRTLAEHIGTPDIASGFQKQGIEAKAVGTMEFAEEISKRI 425 >UniRef50_O81796 Isocitrate dehydrogenase [NAD] regulatory subunit 3, mitochondrial n=42 Tax=Eukaryota RepID=IDH3_ARATH Length = 368 Score = 113 bits (283), Expect = 9e-24, Method: Compositional matrix adjust. Identities = 99/341 (29%), Positives = 165/341 (48%), Gaps = 39/341 (11%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCE 66 + ++PGDGIGP V +V++A+ + Y+V G + + +P +E + Sbjct: 41 VTLIPGDGIGPLVTGAVEQVMEAMH----APVHFERYEVLG-----NMRKVPEEVIESVK 91 Query: 67 QADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRAD 126 + L G + P + + LRK +F++L GL Sbjct: 92 RNKVCLKGGLATPVGGGVSSLN-------MQLRKELDIFASLVNCINVPGLVT------- 137 Query: 127 IAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESAR-K 185 DI+ +RE T G Y G + G E +V +F ERIAR AFE A Sbjct: 138 -RHENVDIVVIRENTEGEYSGL-EHEVVPGVVE---SLKVITKFCSERIARYAFEYAYLN 192 Query: 186 RRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLL 244 R KVT++ KAN+++ + L+ E E+A Y + + +DN MQL+ P QFDV++ Sbjct: 193 NRKKVTAVHKANIMKLADGLFLESCREVAKHYSGITYNEIIVDNCCMQLVAKPEQFDVMV 252 Query: 245 CSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNI-----ANPI 299 NL+G+++++ A I G G++P ++ + ++E G SA ++ + ANP+ Sbjct: 253 TPNLYGNLIANTAAGIAGGTGVMPGGNVGAE-HAIFE-QGASAGNVGNDKMVEQKKANPV 310 Query: 300 AQILSLALLLRYSLDADDAACAIERAINRALEEG-IRTGDL 339 A +LS A++LR+ L A +E A+ + ++EG RT DL Sbjct: 311 ALLLSSAMMLRH-LRFPTFADRLETAVKQVIKEGKYRTKDL 350 >UniRef50_B3RY01 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens RepID=B3RY01_TRIAD Length = 415 Score = 111 bits (277), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 99/345 (28%), Positives = 161/345 (46%), Gaps = 47/345 (13%) Query: 5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEG 64 Y + ++PGDGIGPE+ VL GA ID ++ Sbjct: 88 YTVTLIPGDGIGPEMARHVKTVLHKC----------------GAPID-----FEVIDIKD 126 Query: 65 CEQADAVLFG------SVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLE 118 DA + + G ++ Q A +R+ L+SN+ P K G+ Sbjct: 127 ESSTDAAIISLKRNGIGLKGTITTNISNPQSQSINA--QIRRKLDLYSNIVPCKSIPGVW 184 Query: 119 AFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARI 178 D++ +RE T G Y G + G E ++ + RIA+ Sbjct: 185 T--------RHGQVDLVVIRENTEGEY-GSLEHENVDGVVESL---KIITEKKSRRIAKF 232 Query: 179 AFESA-RKRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKD 236 AF+ A + R KVT+I KAN+++ + L+ E EI+ +Y D+E M IDN MQ++ + Sbjct: 233 AFDYALQNNRRKVTAIHKANIMKLADGLFLETCREISKDYTDIEFESMIIDNCCMQMVTN 292 Query: 237 PSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEP-AGGSAPDIAGKNI 295 P QFDV++ NL+G+I+S + G +G++P ++ ++ + ++E A D+ G N Sbjct: 293 PQQFDVMVMPNLYGNIVSHIGIGLVGGIGLVPGKNIGDK-YAIFESGARNIGSDLVGLNR 351 Query: 296 ANPIAQILSLALLLRYSLDADDAACAIERAINRALEEG-IRTGDL 339 ANP + + AL+LR+ L DD A IE A+ ++ G RT D+ Sbjct: 352 ANPCGFLFTSALMLRH-LGLDDYADIIESAVRTTIKNGKCRTPDI 395 >UniRef50_B4PZH5 GE17383 n=3 Tax=Drosophila RepID=B4PZH5_DROYA Length = 268 Score = 111 bits (277), Expect = 5e-23, Method: Compositional matrix adjust. Identities = 65/185 (35%), Positives = 109/185 (58%), Gaps = 6/185 (3%) Query: 174 RIARIAFESARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQL 233 R++ I FE A R + + S L+ V ++A ++P+++ Y+D + + Sbjct: 88 RLSAIGFE-AHGRLTTGGNYGRLGRRMSDGLFLRCVRDMAQKFPEIQFEEKYLDTVCLNM 146 Query: 234 IKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGK 293 +++P ++DVL+ NL+GDILSD CA + G +G+ PS ++ G L+E G+APDIAGK Sbjct: 147 VQNPGKYDVLVMPNLYGDILSDMCAGLVGGLGLTPSGNMGLNG-ALFESVHGTAPDIAGK 205 Query: 294 NIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEG-IRTGDLARGAAAVSTDEMG 352 ++ANP A +LS ++LR+ ++ + A IERA ++EG TGDL G A ++ Sbjct: 206 DLANPTALLLSAVMMLRH-MELNTYADKIERAAFETIKEGKYLTGDL--GGRAKCSEFTN 262 Query: 353 DIIAR 357 +I A+ Sbjct: 263 EICAK 267 >UniRef50_UPI0001AF2578 isocitrate dehydrogenase [NADP] (oxalosuccinatedecarboxylase) (idh) (nadp(+)-specific icdh) n=1 Tax=Streptomyces roseosporus NRRL 15998 RepID=UPI0001AF2578 Length = 372 Score = 110 bits (274), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 104/371 (28%), Positives = 162/371 (43%), Gaps = 36/371 (9%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATV 62 + Y + ++PGDG GPE++ A VLD +I + G A+ LP AT+ Sbjct: 2 RTYEVTLVPGDGSGPELVDAARSVLDHAARLSGFKIDWDVHQAGQRALAESESLLPDATL 61 Query: 63 EGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAK-LYQGLEAFC 121 A L G P R + +R+ L++ LRP + L Sbjct: 62 NSIRTNGAALKGPTTTPIGTG-------HRSVNITIRQELDLYACLRPVRSLPIASTQEE 114 Query: 122 PLRADIAANGFDILCVRELTGGIYFG--QPKGREGSGQYEKAF---------DTEV---- 166 P R + D++ VRE T +Y G PKG G+ +A DT V Sbjct: 115 PERPHV-----DLVVVRENTEDVYAGLEYPKGSPGARAVVQALGALGRPLPADTAVSLKP 169 Query: 167 YHRFEIERIARIAF-ESARKRRHKVTSI-DKANVLQSSILWREIVNEIATEYPDVELAHM 224 + ER+ AF +AR R V S+ D + ++ + +++A +P + + Sbjct: 170 FTPHGCERVVEFAFNHAARHGRKLVESVCDARRYPATEGMFARVASKVAARHPSIASRTV 229 Query: 225 YIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAG 284 + L++ P + DVL+ NL+GDI+SD A + GS+G+ P A++ ++E Sbjct: 230 PVPALCADLVRAPGRHDVLVLPNLYGDIISDVTAALVGSLGVAPGANIGAH-HAVFEATH 288 Query: 285 GSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEG-IRTGDL---A 340 GSAP+ AG NP A I S +LL + L + A I A+ + G + T DL Sbjct: 289 GSAPEFAGSGRLNPTALIFSGCMLLDH-LGEHETAARIRAAVEDVVAAGEVLTFDLLAPQ 347 Query: 341 RGAAAVSTDEM 351 R A A +T E Sbjct: 348 RSADAATTVEF 358 >UniRef50_D2Y061 Isocitrate dehydrogenase n=1 Tax=Bombyx mori RepID=D2Y061_BOMMO Length = 388 Score = 110 bits (274), Expect = 1e-22, Method: Compositional matrix adjust. Identities = 90/265 (33%), Positives = 139/265 (52%), Gaps = 22/265 (8%) Query: 96 LPLRKHFKLFSNLRPAKLYQGLEAFCPLRADIAANGFDILCVRELTGGIY-FGQPKGREG 154 + LR +++ + K Y G+ DI D++ +R+ T G Y + + G Sbjct: 135 VALRNELDMYAYILNCKSYPGVAT---RHKDI-----DVVIIRQNTEGEYAMLEHESVNG 186 Query: 155 SGQYEKAFDTEVYHRFEIERIARIAFESARKR-RHKVTSIDKANVLQ-SSILWREIVNEI 212 + K + ER+AR AFE A+K R KVT++ KAN+++ S L+ E + Sbjct: 187 VVESMKVVTAD-----NSERVARFAFEFAKKNGRKKVTTVHKANIMKLSDGLFLETSRRL 241 Query: 213 ATEYPDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASL 272 A EYPD+E M IDN MQL+ P QFDV+L +NL+G I+S+ + G G+L + Sbjct: 242 AKEYPDIEHDDMIIDNCCMQLVAKPHQFDVMLMTNLYGSIVSNVVCGLLGGAGLLSGRNY 301 Query: 273 NEQGFGLYEPAG-GSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALE 331 + + ++EP + IAGKNIANPIA I + +L + L A + RAIN+ + Sbjct: 302 GDH-YAVFEPGTRNTGTAIAGKNIANPIAMINASIDMLEH-LGHQFHASLLRRAINKTIN 359 Query: 332 -EGIRTGDLARGAAAVSTDEMGDII 355 + + T DL G + STD +G I+ Sbjct: 360 VDRVLTPDL--GGSNTSTDVVGAIL 382 >UniRef50_UPI00016C59BF Isocitrate dehydrogenase (NAD+) n=1 Tax=Gemmata obscuriglobus UQM 2246 RepID=UPI00016C59BF Length = 341 Score = 108 bits (270), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 97/327 (29%), Positives = 152/327 (46%), Gaps = 37/327 (11%) Query: 29 AVRNRFAMRITTSHYDV---GGAAIDNHGQPLPPATVEGCEQADAVLFGSVGGPKWEHLP 85 +VR FA ++V G A+++ LP AT + + L + PK +P Sbjct: 19 SVRRLFAAAKVPVEFEVHLAGRMALEHGKDALPKATFDAIRECGLALKTKLLQPKGVGMP 78 Query: 86 PDQQPERGAL---LPLRKHFKLFSNLRPAKLYQGLEAFCPLRADIAANGFDILCVRELTG 142 P + R+ LF+++RP G+ P R G D L RE+T Sbjct: 79 TAHGPSSVPTNYNVAFRRQLGLFASMRPVHNLPGI----PSRF----TGVDFLLFREITE 130 Query: 143 GIYFGQPKGREGSGQYEKAFDTEVYHRFEIE------RIARIAFESARKR-RHKVTSIDK 195 +Y E V F+I R ++AF++ARKR R V I K Sbjct: 131 DLYTAS----------EHEIVPGVVQSFKIVTEAACLRFFKLAFDTARKRGRKTVHCIHK 180 Query: 196 ANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILS 254 AN+L+ + L+ E +A EYP++ + +DN QL+ P QF+VL NL+GD+LS Sbjct: 181 ANILKMADGLFLECFYRVAKEYPEIAAKDLIVDNTCNQLVSRPQQFEVLAAGNLYGDLLS 240 Query: 255 DECAMITGSMGMLPSASLNE-QGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSL 313 D A + G G+ +A++N+ G +YE G++ + +++NP+ IL LL+ L Sbjct: 241 DLGAGLVG--GVSTTAAINKGNGTTVYEAVYGASHEAVPPDMSNPLPLILPAIELLK-DL 297 Query: 314 DADDAACAIERAINRALEEG-IRTGDL 339 A I++A+ L EG IRT D+ Sbjct: 298 GETGTAGRIQKAVETVLLEGRIRTRDI 324 >UniRef50_UPI00019260EC PREDICTED: similar to predicted protein isoform 1 n=4 Tax=Hydra magnipapillata RepID=UPI00019260EC Length = 389 Score = 108 bits (269), Expect = 4e-22, Method: Compositional matrix adjust. Identities = 84/266 (31%), Positives = 134/266 (50%), Gaps = 21/266 (7%) Query: 98 LRKHFKLFSNLRPAKLYQGLEAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQ 157 LR L++N+ K Y + N D++ +RE T G Y + G Sbjct: 127 LRHDLDLYANVVKFKSYPTVIT--------RHNNVDLIVIRENTEGEY-TNLEHENIPGV 177 Query: 158 YEKAFDTEVYHRFEIERIARIAFESA-RKRRHKVTSIDKANVLQ-SSILWREIVNEIATE 215 E ++ + + ERIA+ AF+ A R KVT++ KAN+++ S L+ ++ E+A Sbjct: 178 IEM---IKIITKKKSERIAKYAFDYAMENNRKKVTAVHKANIMKLSDGLFLKVCKEVAEG 234 Query: 216 YPDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQ 275 YP+++ M IDN MQ++ P QFDV++ NL+G++LS+ A + G G LP + Sbjct: 235 YPEIDFNDMIIDNCAMQMVSKPEQFDVIVTPNLYGNVLSNIAAALVGGPG-LPHGENHGN 293 Query: 276 GFGLYEPAG-GSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEG- 333 G ++E S DIA KNIANP++ + + LLR+ L A IE I++ + Sbjct: 294 GIHVFESGTRNSGMDIATKNIANPMSMLFAATALLRH-LQLSKHAQLIESCIHKIVTTNQ 352 Query: 334 IRTGDLARGAAAVSTDEMGDIIARYV 359 RT D+ ST E +I+ + V Sbjct: 353 ARTVDI---GGNTSTSEFFEILVKEV 375 >UniRef50_O15384 NAD (H)-specific isocitrate dehydrogenase gamma subunit (Fragment) n=42 Tax=Coelomata RepID=O15384_HUMAN Length = 296 Score = 105 bits (263), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 79/258 (30%), Positives = 134/258 (51%), Gaps = 21/258 (8%) Query: 82 EHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRADIAANGFDILCVRELT 141 +LPP + L R L++N+ ++ L DI DIL VRE T Sbjct: 38 HNLPPSHKSRNNIL---RTSLDLYANVIH---WKSLPGVVTRHKDI-----DILIVRENT 86 Query: 142 GGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARKR-RHKVTSIDKANVLQ 200 G Y + +G E ++ + + RIA AF+ A++ R KVT++ KAN+++ Sbjct: 87 EGEY-SSLEHESVAGVVE---SLKIITKAKSLRIAEYAFKLAQESGRKKVTAVHKANIMK 142 Query: 201 -SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAM 259 L+ + E+A YP + +M +DN TMQL+ P QFDV++ NL+G+I+++ CA Sbjct: 143 LGDGLFLQCCREVAARYPQITFENMIVDNTTMQLVSRPQQFDVMVMPNLYGNIVNNVCAG 202 Query: 260 ITGSMGMLPSASLNEQGFGLYEPAG-GSAPDIAGKNIANPIAQILSLALLLRYSLDADDA 318 + G G++ A+ + ++E A + IA KNIANP A +L+ ++L + L Sbjct: 203 LVGGPGLVAGANYG-HVYAVFETATRNTGKSIANKNIANPTATLLASCMMLDH-LKLHSY 260 Query: 319 ACAIERAINRALE-EGIR 335 A +I +A+ +++ E +R Sbjct: 261 ATSIRKAVLASMDNENVR 278 >UniRef50_A9KQX3 Isocitrate dehydrogenase (NAD(+)) n=5 Tax=cellular organisms RepID=A9KQX3_CLOPH Length = 387 Score = 105 bits (262), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 89/313 (28%), Positives = 149/313 (47%), Gaps = 30/313 (9%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQ---PLPPATVE 63 I V GDGIGP + +QA ++L+ + ++ + G I+ +P ++ Sbjct: 44 IGVCGGDGIGPAITSQAQRILEYLLKDDILQGKVEFKVIDGLTIERRAAEHAAIPAEVLK 103 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 ++ +L G P+ P+ + A + +RK LF+N+RP + Sbjct: 104 ELKECHVILKGPTTTPRKGDPWPNVES---ANVAMRKELDLFANVRPVR----------- 149 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 I G D RE T G Y KG + + D V ERI R AFE A Sbjct: 150 ---IPEQGIDWTFYRENTEGAYAVGSKGIHVT--EDLGVDFTVVTSGGSERIIRAAFEYA 204 Query: 184 RKR-RHKVTSIDKANVLQSSI-LWREIVNEIATEYPDVELAHMYIDNATMQLI--KDPSQ 239 + + +VT++ KAN+++++ + +I EIA +Y D+ YID T +LI K Sbjct: 205 KANGKTRVTAVTKANIIKTTDGKFLDIFREIAKDYKDITADDWYIDIMTAKLIDEKRRKD 264 Query: 240 FDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGK---NIA 296 F V++ NL+GDI++DE A G +G SA++ ++ + ++E GSAP + + A Sbjct: 265 FQVMVLPNLYGDIITDEAAEFQGGVGTAGSANIGKR-YSMFEAIHGSAPRMVQEGRDQYA 323 Query: 297 NPIAQILSLALLL 309 +P + I + A+LL Sbjct: 324 DPCSVIRAGAMLL 336 >UniRef50_Q9U6V3 Isocitrate dehydrogenase gamma subunit n=4 Tax=Bilateria RepID=Q9U6V3_9BILA Length = 388 Score = 103 bits (258), Expect = 8e-21, Method: Compositional matrix adjust. Identities = 90/316 (28%), Positives = 157/316 (49%), Gaps = 39/316 (12%) Query: 5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPAT--- 61 + + +LPGDGIGPE+ LD V+ F T ++ V +P P + Sbjct: 45 HTVTLLPGDGIGPEM-------LDIVQKIF----TFANVPVDFEECQLDSKPTSPESDLD 93 Query: 62 --VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEA 119 + ++ + G++ + + + E LR+ LF+N+ L+ Sbjct: 94 NAIMSIQRNGVAIKGNIETKYDDPIFKSRNVE------LRRRLDLFANV----LHCVSIP 143 Query: 120 FCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIA 179 P R G +I+ +RE T G Y G + +G E ++ R ++ERI+R A Sbjct: 144 TIPTRH----KGINIVMIRENTEGEYSGH-EHETVNGVVESL---KICTREKLERISRFA 195 Query: 180 FESA-RKRRHKVTSIDKANVLQ-SSILWREIVNEIA-TEYPDVELAHMYIDNATMQLIKD 236 F+ A R K+T++ KAN+ + + L+ ++V EIA EYP + M +DNA+MQL+ Sbjct: 196 FDYAIAHNRKKITAVHKANIQKLADGLFLKVVGEIAEKEYPSITFDSMIVDNASMQLVSR 255 Query: 237 PSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAG-GSAPDIAGKNI 295 P QFD++L NL+G+I+S+ + G G++ ++ ++ + ++E + IAG++I Sbjct: 256 PQQFDIMLMPNLYGNIISNIACGLVGGPGLVSGMNIGDK-YAVFETGTRNTGSGIAGQDI 314 Query: 296 ANPIAQILSLALLLRY 311 ANP A I + +L Y Sbjct: 315 ANPTAFIRAGVDMLHY 330 >UniRef50_O13696 Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial n=76 Tax=Fungi/Metazoa group RepID=IDH1_SCHPO Length = 356 Score = 103 bits (257), Expect = 9e-21, Method: Compositional matrix adjust. Identities = 104/358 (29%), Positives = 164/358 (45%), Gaps = 31/358 (8%) Query: 5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEG 64 Y + ++PGDGIG E ++ + I DV G +N ++ + Sbjct: 21 YTVTLIPGDGIGRETSNAVTEIFKTAN----VPIEFEEIDVTGMEKNNK------SSGDA 70 Query: 65 CEQADAVLFGSVGGPKWEHLPPDQQPERGAL-LPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 +A L + G K P ++ + + LRK ++++L K G + Sbjct: 71 LHEAIQSLKRNKVGLKGILFTPFEKGGHTSFNVALRKELDIYASLVLIKNIPGFKT---- 126 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 R D D +RE T G Y G + G E ++ ++ +RIA+ AF+ A Sbjct: 127 RHD----NVDFAIIRENTEGEYSGLEH-QSVPGVVE---SLKIITEYKSKRIAQFAFDFA 178 Query: 184 RKR-RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFD 241 + R VT I KAN+++ + L+R ++A Y + + +DNA+MQ + P QFD Sbjct: 179 LQNGRKSVTCIHKANIMKLADGLFRRTFYDVANGYDAITPKDLIVDNASMQAVSRPQQFD 238 Query: 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAP-DIAGKNIANPIA 300 VL+ NL+G ILS+ + + G G++P A+ + L+EP I G+ ANP A Sbjct: 239 VLVMPNLYGSILSNIGSALVGGPGVIPGANFGRD-YALFEPGCRHVGLSITGRGEANPTA 297 Query: 301 QILSLALLLRYSLDADDAACAIERAINRALEEG-IRTGDLARGAAAVSTDEMGDIIAR 357 ILS L+LR+ L D A I A +EEG T DL G +A + D I+ R Sbjct: 298 AILSACLMLRH-LGLKDYADLINAATYSVIEEGKTLTKDL--GGSASTGDFTHAILER 352 >UniRef50_C7P3E9 Isocitrate dehydrogenase, NADP-dependent n=5 Tax=Halobacteriaceae RepID=C7P3E9_HALMD Length = 425 Score = 103 bits (256), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 112/409 (27%), Positives = 175/409 (42%), Gaps = 66/409 (16%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPA 60 + +N + ++ GDGIG +V A KVL+A N I+ G +A + + + LP Sbjct: 29 IPENPIVPIIHGDGIGKDVGPAAQKVLEAAANATGREISWMRVFAGESAREKYDENLPDD 88 Query: 61 TVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAF 120 TV ++ + G + P R + LR+ +SN+RP G+ + Sbjct: 89 TVNAIDEHRVAIKGPLTTPVGAGF-------RSLNVALRQTLDFYSNVRPTYYLDGVPS- 140 Query: 121 CPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEK---------AFDTEVYH--- 168 P++ A D++ RE T +Y G + G+ + E+ FD +V H Sbjct: 141 -PMK---APEEMDMVTFRENTEDVYAGI-EWEAGTEEVEQVREFVEEDMGFD-DVMHDGP 194 Query: 169 ---------RFEIERIARIAFESA-RKRRHKVTSIDKANVLQ-SSILWREIVNEIA-TEY 216 F +R+ R A + A R KVT + K N+++ + + E E+A EY Sbjct: 195 IGIGIKPITEFGSKRLVRKAIDYAIEHDRDKVTLVGKGNIMKFTEGQFTEWGMEVADEEY 254 Query: 217 PDVE----------------------LAHMYIDNATMQLIK-DPSQFDVLLCSNLFGDIL 253 PD E + + +A +Q ++ +F VL NL GD L Sbjct: 255 PDDEVFAAPDSLWETQDEIDIPEDAVMVESRLADAMLQWMQLRTDEFSVLAMPNLNGDYL 314 Query: 254 SDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSL 313 SD G +G+ P A+ + L EP GSAP AG+N+ANP A ILS L+ Y + Sbjct: 315 SDAAGAQIGGLGIAPGANFGDARV-LAEPVHGSAPKRAGQNMANPTAMILSGRLMFDY-M 372 Query: 314 DADDAACAIERAINRALEEGIRTGDLAR---GAAAVSTDEMGDIIARYV 359 DAA + A+ + G T DL R A + T+E D I + Sbjct: 373 GWKDAADLVRDAVEETISSGTVTYDLERQLEDAEKLGTEEYSDAIVENI 421 >UniRef50_Q6GG12 Isocitrate dehydrogenase [NADP] n=90 Tax=root RepID=IDH_STAAR Length = 422 Score = 103 bits (256), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 113/411 (27%), Positives = 174/411 (42%), Gaps = 80/411 (19%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRF---AMRITTSHYDVGGAAIDNHGQPLPPATVE 63 I + GDGIGP++ A +V+DA + RI G A D G+ LP T++ Sbjct: 21 IPFIIGDGIGPDIWKAASRVIDAAVEKAYNGEKRIEWKEVLAGQKAFDTTGEWLPQETLD 80 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 ++ +V GP P R + LR+ LF+ LRP + ++G+ + Sbjct: 81 TIKE----YLIAVKGP---LTTPIGGGIRSLNVALRQELDLFTCLRPVRWFKGVPSPVKR 133 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFD--------TEVYHRFE---- 171 D+ D++ RE T IY G + +EG+ + +K D T + RF Sbjct: 134 PQDV-----DMVIFRENTEDIYAG-IEFKEGTTEVKKVIDFLQNEMGATNI--RFPETSG 185 Query: 172 ----------IERIARIAFESA-RKRRHKVTSIDKANVLQSS------------------ 202 ER+ R A + A R VT + K N+++ + Sbjct: 186 IGIKPVSKEGTERLVRAAIQYAIDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLALTEFGD 245 Query: 203 --ILWR---EIVNE-------IATEYPDVE----LAHMYIDNATMQLIKDPSQFDVLLCS 246 W+ EIV + +A E + E + D Q++ P++ DV+ Sbjct: 246 QVFTWQQYDEIVEKEGRDAANVAQEKAEKEGKIIIKDSIADIFLQQILTRPAEHDVVATM 305 Query: 247 NLFGDILSDECAMITGSMGMLPSASLN-EQGFGLYEPAGGSAPDIAGKNIANPIAQILSL 305 NL GD +SD A G +G+ P A++N E G ++E G+AP AG N NP + ILS Sbjct: 306 NLNGDYISDALAAQVGGIGIAPGANINYETGHAIFEATHGTAPKYAGLNKVNPSSVILSS 365 Query: 306 ALLLRYSLDADDAACAIERAINRALEEGIRTGDLAR---GAAAVSTDEMGD 353 L+L + L +AA I +I + + T D AR GA VST D Sbjct: 366 VLMLEH-LGWQEAADKITDSIEDTIASKVVTYDFARLMDGAEEVSTSAFAD 415 >UniRef50_C7YNU4 Putative uncharacterized protein n=1 Tax=Nectria haematococca mpVI 77-13-4 RepID=C7YNU4_NECH7 Length = 307 Score = 101 bits (252), Expect = 4e-20, Method: Compositional matrix adjust. Identities = 69/207 (33%), Positives = 111/207 (53%), Gaps = 18/207 (8%) Query: 85 PPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRADIAANGFDILCVRELTGGI 144 P +PERG LL LRK + ++RP + P + + C R + Sbjct: 38 PATSRPERG-LLKLRKEMGTYGSMRPC-FFASDSLVAPQGRGVPRHRL-CHCARAHRRYL 94 Query: 145 YFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIA-FESARKRRHKVTSIDKANVLQSSI 203 + + + GSG A++TE Y E+ER +A F + + K+ S+D ANVL +S Sbjct: 95 LW---RAQTGSGS---AWNTEPYSHAEVERFTHLAGFLTRGRGDKKLWSLDNANVLATSR 148 Query: 204 LWREIVNE-IATEYPDVELAHMYIDNATMQLIKDPSQFD-VLLCSNLFGDILSDECAMIT 261 WR+++ E E+PD+++ H I++A M ++K+P+ + V++ S LFGDI+SD +I Sbjct: 149 FWRKVMTETFEKEFPDLKVEHQLINSAVMIMVKNPTGLNGVVVTSTLFGDIISDAARVIP 208 Query: 262 GSMGMLPSASL------NEQGFGLYEP 282 S+G+LPSASL N + +YEP Sbjct: 209 DSIGLLPSASLSGIPDGNRKSNDIYEP 235 >UniRef50_A6GJ83 Isocitrate dehydrogenase n=1 Tax=Plesiocystis pacifica SIR-1 RepID=A6GJ83_9DELT Length = 344 Score = 99.8 bits (247), Expect = 2e-19, Method: Compositional matrix adjust. Identities = 102/346 (29%), Positives = 161/346 (46%), Gaps = 43/346 (12%) Query: 5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEG 64 Y I L GDGI E+ V DA+ I D+ + + G + Sbjct: 9 YSIVELHGDGIARELSQAVHTVADAL----PFEIEFIPVDLSDESREAKGDAI------- 57 Query: 65 CEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 ++A+A + K+ + P R +L R +F + RP G++ R Sbjct: 58 YDEAEAAMRRYGTSLKYPTATTKESPNR--VLRERCNFAVIH--RPVATIPGIQTHYNER 113 Query: 125 ADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIER-----IARIA 179 + DI VR TGG Y + GR + DT V R IER +R A Sbjct: 114 IHL-----DI--VRIATGGTY--EDAGRRINR------DTAVSIR-AIERRPSVLASRFA 157 Query: 180 FESARKRRHKVTSIDKANVLQSSI-LWREIVNEIATEYPDVELAHMYIDNATMQLIKDPS 238 F A+ R V + K + +++ L++E +A +YP E D +I P Sbjct: 158 FRLAQLRDSNVIATSKYTIQKATDGLFQEAARGVARDYPATEFREELFDALLAGIIMRPE 217 Query: 239 QFDVLLCSNLFGDILSDECAMITGSMGMLPSA--SLNEQG---FGLYEPAGGSAPDIAGK 293 ++ V++C N +GD LSD + GS+G+ SA S + QG +++PAGG+APDIAG+ Sbjct: 218 RYGVIVCPNEYGDFLSDMAYGLIGSIGLGDSASYSFDSQGQVDVAMFDPAGGTAPDIAGQ 277 Query: 294 NIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDL 339 N ANP A +L++A +LR+ + D++ A+ A+ A+E G +T D+ Sbjct: 278 NKANPTAALLAMANMLRH-IGEHDSSKALRGALFGAIEAGEKTADI 322 >UniRef50_D2RVT1 Isocitrate dehydrogenase, NADP-dependent n=1 Tax=Haloterrigena turkmenica DSM 5511 RepID=D2RVT1_9EURY Length = 425 Score = 98.6 bits (244), Expect = 3e-19, Method: Compositional matrix adjust. Identities = 115/413 (27%), Positives = 174/413 (42%), Gaps = 78/413 (18%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQP--LPPAT 61 N I ++ GDGIG +V A KVL+A I+ G +A + +G+ LP T Sbjct: 30 NPIIPIIHGDGIGKDVGPAAQKVLEAAAEATGRDISWMRVYAGESAREEYGEDVNLPDET 89 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 V+ + + G + P R + LR+ L++N+RP G+ + Sbjct: 90 VDAIREHRVAIKGPLTTPVGAGF-------RSLNVALRQTLDLYANVRPTYYLDGVPS-- 140 Query: 122 PLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEK---------AFDTEVYHRFEI 172 P++A D++ RE T +Y G + G+ + E+ FD E H I Sbjct: 141 PMKA---PEEMDMVTFRENTEDVYAGI-EWEAGTDEVEQVREFVEDEMGFD-ETMHDGPI 195 Query: 173 ------------ERIARIAFESARKR-RHKVTSIDKANVL-----QSSILWREIVNEIAT 214 +R+ R A + A + R KVT + K N++ Q E+ +E Sbjct: 196 GIGLKPITEKGSKRLVREAIDYALEHDRDKVTLVHKGNIMKFTEGQFGDWGMEVADE--- 252 Query: 215 EYPDVE----------------------LAHMYIDNATMQLIK-DPSQFDVLLCSNLFGD 251 EYPD E + + +A +Q ++ +FD+L NL GD Sbjct: 253 EYPDDEVFAAPDSLWETQDEVDIPEDAVMVEERLADAMLQWMQLRTDEFDILAMPNLNGD 312 Query: 252 ILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRY 311 LSD G +G+ P + +G L EP GSAP AG+++ANP A ILS L+ Y Sbjct: 313 YLSDAAGAQIGGLGIAPGGNFG-KGRMLAEPVHGSAPKRAGQDMANPTAMILSGRLMFDY 371 Query: 312 SLDADDAACAIERAINRALEEGIRTGDLARG-------AAAVSTDEMGDIIAR 357 L DDAA I A+ + G T DL R + TDE+ D I + Sbjct: 372 -LGWDDAADLIRDAVEETISSGKVTYDLERQLEDAEKLGTSEYTDEIVDTIEK 423 >UniRef50_A9B3D4 Isocitrate/isopropylmalate dehydrogenase n=4 Tax=Bacteria RepID=A9B3D4_HERA2 Length = 246 Score = 97.8 bits (242), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 74/264 (28%), Positives = 119/264 (45%), Gaps = 40/264 (15%) Query: 5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEG 64 + + ++ GDG GPE+ +VL+A F I + DV ++ G PLP + +E Sbjct: 3 HRVTLIRGDGTGPELAEATRRVLEATGVAFDWDIQDAGVDV----MEQLGTPLPDSVLES 58 Query: 65 CEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 L + P R + +RK L++ +RP + Y G+ + Sbjct: 59 IRSTKVALKAPITTPVGTGF-------RSVNVAIRKELDLYACVRPCRSYPGVRS----- 106 Query: 125 ADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEI------------ 172 D++ VRE T +Y G R G+ + + + + R Sbjct: 107 ---RFENIDLVVVRENTEDLYAGIEFER-GTDEVAELRNWLLQKRPNALIKEPGGISIKP 162 Query: 173 ------ERIARIAFESAR-KRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHM 224 ERI R AFE AR +R KVT++ KAN+++ S L+ E+ E+A EYPD+E Sbjct: 163 MSVPGSERIVRFAFEYARANKRKKVTAVHKANIMKFSDGLFLEVAREVAKEYPDIEFDDR 222 Query: 225 YIDNATMQLIKDPSQFDVLLCSNL 248 +DN MQL++ P +DV++ NL Sbjct: 223 IVDNMCMQLVQKPELYDVMVLPNL 246 >UniRef50_D2VM48 Isocitrate dehydrogenase n=1 Tax=Naegleria gruberi RepID=D2VM48_NAEGR Length = 432 Score = 97.1 bits (240), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 81/260 (31%), Positives = 134/260 (51%), Gaps = 25/260 (9%) Query: 102 FKLFSNLRPAKLYQGL--EAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYE 159 + L++++ P K Q L F P R D++ VRE T Y G E Q Sbjct: 164 YGLYAHVVPVKAPQNLPPSVFTPFR------DVDMVVVRENTEAEY----SGLEHQVQPG 213 Query: 160 KAFDTEVYHRFEIERIARIAFESARK-RRHKVTSIDKANVLQSSI-LWREIVNEIATEYP 217 ++ R RIA+ AFE A++ +R KV +I KAN+++ S L+ E ++A EYP Sbjct: 214 VVESLKIITRDGSMRIAKWAFEYAKQSKRSKVIAIHKANIMKKSDGLFIECCKQVAKEYP 273 Query: 218 DVELAHMYIDNATMQLIKDPSQFD--VLLCSNLFGDILSDECAMITGSMGMLP---SASL 272 D++ + + +DNA MQL+K+P FD V++ NL+G I+S+ + + G +G++ + + Sbjct: 274 DIQYSELIVDNAVMQLVKNPHSFDNSVVVTPNLYGSIVSNTASSLVGGVGVISGFNATDI 333 Query: 273 NE-QGFGLYEPAGGS-APDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRAL 330 N+ ++E A DI+G+ IANPI I S +L + + + A I+ A+ L Sbjct: 334 NKPDAVRVFEQGNRHVAMDISGRLIANPIGLISSSIQMLDH-MGMNTHANRIKFALKETL 392 Query: 331 ---EEGIRTGDLARGAAAVS 347 I T D+ ++VS Sbjct: 393 LNANPKILTPDIGGTGSSVS 412 >UniRef50_Q3IKZ8 Isocitrate dehydrogenase, specific for NADP+ n=3 Tax=Alteromonadales RepID=Q3IKZ8_PSEHT Length = 419 Score = 94.7 bits (234), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 105/382 (27%), Positives = 161/382 (42%), Gaps = 68/382 (17%) Query: 7 IAVLPGDGIGPEVMTQALKVLD--------AVRNRFAMRITTSHYDVGGAAIDNHGQPLP 58 IA + GDG+G +VM KV+D A R M++ Y+ AA G P Sbjct: 34 IAYIDGDGVGQDVMPVMRKVVDSAIAHCYQAKRKIHWMQV----YNGEQAAKLYDGDWFP 89 Query: 59 PATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLE 118 T+ + + G + P R + LR+ LF N+R K + L Sbjct: 90 QETINAVRECKIAIKGPLTTPLGGGF-------RSLNVALRQEMDLFVNMRTIKGFSALP 142 Query: 119 AFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFD--------TEVYHRF 170 + PL+ N I +R+ + +Y G + + GS + EK D T + Sbjct: 143 S--PLKNPYLTN---ITVLRDSSEDVYSG-IEWQAGSVESEKVLDFLCEEMGVTRLRFTQ 196 Query: 171 EI------------ERIARIAFESARKRRHK-VTSIDKANVLQSS---------ILWREI 208 E ER+ R A A K + +T + K NVL+ + L + Sbjct: 197 ECGIGIKNISKEGSERLVRYAINYALKNNSESLTLVHKGNVLKFTDGAFKRWGFALAKRE 256 Query: 209 VNEIATE-----------YPDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDEC 257 I E P + + + DN Q + P QFDV+ +N GD L+D Sbjct: 257 YQAIDDENGRWLHIPRQGQPPLIIKEVIADNMLQQCLMHPEQFDVVATTNQNGDFLADML 316 Query: 258 AMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADD 317 + G +G++P+A+LN + +EP G+ IAG+N ANP + ILS L+L++ + + Sbjct: 317 SAQVGGVGIMPAANLNNE-VAFFEPTHGTFARIAGQNKANPSSSILSAVLMLKF-MQWHE 374 Query: 318 AACAIERAINRALEEGIRTGDL 339 AA IE A+ R L G T DL Sbjct: 375 AANLIENALERTLAAGEVTFDL 396 >UniRef50_UPI000186E03D isocitrate dehydrogenase, putative n=1 Tax=Pediculus humanus corporis RepID=UPI000186E03D Length = 406 Score = 92.8 bits (229), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 99/365 (27%), Positives = 163/365 (44%), Gaps = 42/365 (11%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRI-TTSHYDVGGAAIDNHGQPLPPATVEG 64 ++ +L G GIGPE+M L+VL A + I S D G+ ++ + L Sbjct: 39 NVTILTGSGIGPEIMDHTLRVLKAAGAPLSYEIFALSSKD--GSKNNDFDEAL-----TS 91 Query: 65 CEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 + L G++ L + + RK LF + K + GL Sbjct: 92 IRRNRVALKGNI------ELQSKNPHIKSRNIIFRKTLDLFVYILFCKTFPGL------- 138 Query: 125 ADIAANGF---DILCVRELTGGIYFG-QPKGREGSGQYEKAFDTEVYHRFEIERIARIAF 180 +N F DI +R+ T G Y + + R GS + K V RF +ER+ AF Sbjct: 139 ----SNKFGEIDITVIRQNTEGEYLMLEHEPRTGSVESLK-----VLTRFNLERLIEFAF 189 Query: 181 ESARKR-RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPS 238 + A R +T + AN+ + + L+ N+I+ YP +++ + ++ A ++ +P Sbjct: 190 DYALTNDRKLITVVHNANIQKLTEGLFLNAANKISKSYPMIKMNVLDVNVAIFKIASNPR 249 Query: 239 QFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEP-AGGSAPDIAGKNIAN 297 FDV+L +NL G ++S+ + G G+ + + G ++EP A I G N AN Sbjct: 250 IFDVILATNLNGSMISNYLNGMLGGPGLTSGINFSADGIAVFEPGARNKGSSIVGLNRAN 309 Query: 298 PIAQILSLALLLRYSLDADDAACAIERAINRAL-EEGIRTGDLARGAAAVSTDEMGDIIA 356 PIA I+S LL + L + A I ++ L + IRT D+ A A +E D I Sbjct: 310 PIAMIMSGINLLHH-LGYNKTAEMIHNSVYATLVYDKIRTPDIGGQATA---EETVDHII 365 Query: 357 RYVAE 361 R++ E Sbjct: 366 RHIRE 370 >UniRef50_A8E541 Idh3a protein n=4 Tax=Euteleostomi RepID=A8E541_DANRE Length = 157 Score = 92.0 bits (227), Expect = 3e-17, Method: Compositional matrix adjust. Identities = 46/111 (41%), Positives = 69/111 (62%), Gaps = 11/111 (9%) Query: 205 WRE----IVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMI 260 WR I+ I T+ P + + +++DPSQFDVL+ NL+GDILSD CA + Sbjct: 5 WRSTVSCIMGAIKTQTPQPRVF-------SRGMVQDPSQFDVLVMPNLYGDILSDLCAGL 57 Query: 261 TGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRY 311 G +G+ PS ++ G ++E G+APDIAGK++ANP A +LS ++LR+ Sbjct: 58 IGGLGVTPSGNIGANGVAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRH 108 >UniRef50_UPI0001910A87 3-isopropylmalate dehydrogenase n=1 Tax=Salmonella enterica subsp. enterica serovar Typhi str. E98-2068 RepID=UPI0001910A87 Length = 51 Score = 90.5 bits (223), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 45/51 (88%), Positives = 49/51 (96%) Query: 313 LDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYVAEGV 363 +DAD+AA AIE+AINRALEEG+RT DLARGAAAVSTDEMGDIIARYVAEGV Sbjct: 1 MDADEAATAIEQAINRALEEGVRTSDLARGAAAVSTDEMGDIIARYVAEGV 51 >UniRef50_A5BNI3 Putative uncharacterized protein n=1 Tax=Vitis vinifera RepID=A5BNI3_VITVI Length = 175 Score = 89.7 bits (221), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 50/111 (45%), Positives = 66/111 (59%), Gaps = 1/111 (0%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATV 62 K Y I +LPGDGIGPEV++ A VL + + VGG A+D G PLP T+ Sbjct: 41 KRYSITLLPGDGIGPEVISVAKNVLKLAGSLEGIEFGFQEMPVGGCALDLTGVPLPEETL 100 Query: 63 EGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKL 113 +Q+DAVL G++GG KW+ +PE G LL LR K+F+NLRPA + Sbjct: 101 LVAKQSDAVLLGAIGGYKWDSNEKHLKPETG-LLQLRSGLKVFANLRPASV 150 >UniRef50_C0WN79 Isocitrate dehydrogenase [NADP] n=4 Tax=Lactobacillus RepID=C0WN79_LACBU Length = 429 Score = 89.4 bits (220), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 107/418 (25%), Positives = 163/418 (38%), Gaps = 74/418 (17%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDA-VRNRFAMRITTSHYDV--GGAAIDNHGQPLPPA 60 N I + GDGIGPE+ A V DA V+ + + + + G A GQ LP Sbjct: 18 NPTIPFIEGDGIGPEIWKAAKTVFDAAVKKAYDGQKQVNWLPLLAGETAYKKTGQWLPDK 77 Query: 61 TVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAF 120 T+ A L + G K P R + LR+ L++ RP Y G + Sbjct: 78 TL-------ATLREYLVGIKGPLTTPIGIGHRSINVTLRQKLDLYACFRPVTYYPGTPS- 129 Query: 121 CPLRADIAANGFDILCVRELTGGIYFG-------------------QPKGREGSGQYEKA 161 P+ + +I RE T IY G Q K + A Sbjct: 130 -PV---VHPENVNIDVFRENTEDIYAGIESDVDTKDAEEWKSLLAKQDKLSKVRFPDTSA 185 Query: 162 FDTEVYHRFEIERIARIAFESA-RKRRHKVTSIDKANVLQSS------------------ 202 F + + R+ A + A RH +T + K N+++ + Sbjct: 186 FAIKPISKQGSTRLVDAAIDYAFANNRHTLTLVHKGNIMKKTEGGFKKWGYEAAEKYGDK 245 Query: 203 -ILWREIVNEIATEYPDVELAHMY---------------IDNATMQLIKDPSQFDVLLCS 246 W + N+I + + Y DN Q + P F+V+ Sbjct: 246 VFTWNQ-YNQIKADQGEKAADQAYQTARDEQKLIVNDVITDNFFQQALLHPEHFEVVATM 304 Query: 247 NLFGDILSDECAMITGSMGMLPSASLNEQ-GFGLYEPAGGSAPDIAGKNIANPIAQILSL 305 NL GD +SD A G +G+ P ++N Q G ++E G+AP AG+N NP + ILS Sbjct: 305 NLNGDYISDALAAQVGGIGIAPGGNINYQTGHAIFEATHGTAPQFAGQNKLNPTSIILSG 364 Query: 306 ALLLRYSLDADDAACAIERAINRALEEGIRTGDLARG--AAAVSTDEMGDIIARYVAE 361 A++ Y L DD + I I RA++ T D A+ A +ST G+ +A+ + E Sbjct: 365 AMMFDY-LGWDDVSNLIRIGIKRAIKSHHVTVDFAKTPDATVLSTSGFGEYVAQLIEE 421 >UniRef50_B0BZF3 Isocitrate dehydrogenase NAD-dependent n=1 Tax=Acaryochloris marina MBIC11017 RepID=B0BZF3_ACAM1 Length = 348 Score = 89.0 bits (219), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 87/343 (25%), Positives = 155/343 (45%), Gaps = 48/343 (13%) Query: 17 PEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQP----LPPATVEGCEQADAVL 72 P V+ Q ++ V N M I + D+ +D G+ LP + A + Sbjct: 4 PVVLIQEGELGAQVTNALQMAIAATGVDITWQIVDIGGEDQQGLLPNYIFDIIRTAKTAV 63 Query: 73 FGSVGGP-KWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRADIAANG 131 G + P + + D +R+ L+ NLRPAK G+ + Sbjct: 64 IGPLMMPDNYRQMEAD----------IREKLDLYVNLRPAKTMVGIPS--------NYQN 105 Query: 132 FDILCVRELTGGIYFGQPKGREGSGQYE-KAFDTEVYHRFEIE---------------RI 175 DI+ VRE T GIY G R + ++F +++ + E +I Sbjct: 106 VDIMIVRETTEGIYAGIEFERTSVEAADARSFLSKLSGKRIREDAAVGIKPISVKGCGQI 165 Query: 176 ARIAFESARK-RRHKVTSIDKANVL-QSSILWREIVNEIATEYPDVELAHMYIDNATMQL 233 AF ARK +RH+V ++ +A+ + + L+ EI +IA E+PD+ A I+ +L Sbjct: 166 IEFAFNYARKTKRHQVIAVHQAHFMAHTDGLFLEIARDIAQEFPDIAFADRSIEVICQEL 225 Query: 234 IKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGK 293 ++ P +FDVL+ NL+GD+L+ CA + G + +P A + ++ + ++ D+ Sbjct: 226 MQKPERFDVLVMPNLYGDLLAHLCAGMVGGLS-VPIAHVGDK-YAVFGAQSTGTDDVG-- 281 Query: 294 NIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRT 336 +P + IL+ AL+LR+ L +AA ++ A+ + + T Sbjct: 282 --HDPTSLILAGALMLRH-LGEQEAAQRLQAAVEAVVASHVDT 321 >UniRef50_B4MP27 GK19462 n=1 Tax=Drosophila willistoni RepID=B4MP27_DROWI Length = 390 Score = 87.0 bits (214), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 74/253 (29%), Positives = 116/253 (45%), Gaps = 24/253 (9%) Query: 94 ALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRADIAANGFDILCVRELTGGIYFG-QPKGR 152 L LRK F+LF+ + + +G + D L +R+ G Y G + + Sbjct: 58 CLRKLRKKFQLFAFVAVCRNLEG--------QNTRYGKLDCLIIRDQVEGEYSGIEHRVV 109 Query: 153 EGSGQYEKAFDTEVYHRFEIERIARIAFESARKR-RHKVTSIDKANVLQSS--ILWREIV 209 G Q K E +R+AR FE A+K R K+T KAN+++ + + Sbjct: 110 PGVMQTIKVSTAE-----GADRMARYVFEYAKKNNRKKITVAHKANIMRLTDGTFLSPMR 164 Query: 210 NEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPS 269 E A D+ Y+D + ++ P + DVL+ S+++GD+L+ A I G + P Sbjct: 165 REAAKYQDDIMFEERYLDTVCLAMLMKPERKDVLVASSMYGDVLTFMAASIMGGPALCPG 224 Query: 270 ASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLR-YSLD--ADDAACAIERAI 326 ++ G +YEP + +IAGK+I NP +LS L+LR L+ AD CA+ Sbjct: 225 FAVGPMGL-IYEPIIHTNTNIAGKDIVNPTGMLLSGVLMLREMKLNEYADKICCAVSTVF 283 Query: 327 NRALEEGIRTGDL 339 E RT DL Sbjct: 284 R---ETDCRTKDL 293 >UniRef50_Q9ZN36 Isocitrate dehydrogenase [NADP] n=932 Tax=root RepID=IDH_HELPJ Length = 425 Score = 85.9 bits (211), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 102/406 (25%), Positives = 173/406 (42%), Gaps = 73/406 (17%) Query: 7 IAVLPGDGIGPEVMTQALKVLD-AVRNRFAMRITTSHYDV-----------GGAAIDNHG 54 I + GDGIG ++ +KV+D AV+ + + Y+V + Sbjct: 32 IPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIAWYEVFVGEKCYQKFKDHKELSPEE 91 Query: 55 QPLPPATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLY 114 Q L P T+E + G + P E R + LR+ L+ LRP + Y Sbjct: 92 QWLLPDTIEAINHYKVSIKGPLTTPIGEGF-------RSLNVALRQKMDLYVCLRPVRWY 144 Query: 115 QGLEAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAF-----DTEVYH- 168 + P++ D++ RE + IY G + +EGS + +K + +V Sbjct: 145 G---SPSPVKE---PQKVDMVIFRENSEDIYAGI-EWQEGSAEAKKLIHFLQNELKVEKI 197 Query: 169 RFE--------------IERIARIAFESA-RKRRHKVTSIDKANVLQSS----ILW---- 205 RF ER+ R A E A + VT + K N+++ + + W Sbjct: 198 RFPESSGVGIKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYTEGAFMKWGYAL 257 Query: 206 --REIVNEIATEYP-----------DVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDI 252 +E ++ + P ++ + M D Q++ PS++ V+ NL GD Sbjct: 258 AQKEFNAQVIDKGPWCSLKNPKTGKEIIIKDMIADAFLQQILLRPSEYSVIATMNLNGDY 317 Query: 253 LSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYS 312 +SD A + G +G+ P A+LN+ G++E G+AP AG + NP + ILS ++LR+ Sbjct: 318 ISDALAAMVGGIGIAPGANLNDT-VGMFEATHGTAPKYAGLDKVNPGSIILSAEMMLRH- 375 Query: 313 LDADDAACAIERAINRALEEGIRTGDLAR---GAAAVSTDEMGDII 355 + +AA I A+ +A++ T D AR GA V E ++ Sbjct: 376 MGWVEAADLIVSAMEKAIKSKKVTYDFARLMDGAKEVKCSEFASVM 421 >UniRef50_D2RML7 Isocitrate/isopropylmalate dehydrogenase n=6 Tax=cellular organisms RepID=D2RML7_ACIFE Length = 393 Score = 83.6 bits (205), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 79/315 (25%), Positives = 134/315 (42%), Gaps = 30/315 (9%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQP---LPPATVE 63 + +LPGDGIGP +M QAL+V + + G I+ Q LP +E Sbjct: 49 VGILPGDGIGPCIMEQALRVAKYLLKDEMASGKVEFRTIPGMTIEERVQKNESLPAEVLE 108 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 C+ D ++ G P+ P+ LR+ +L++ +RP + Sbjct: 109 ACKACDVLVKGPFVTPRAGDPWPNMVSANSL---LRRALQLYAAVRPVR----------- 154 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 I G D RE G Y KG + A D +V R ERI R AFE A Sbjct: 155 ---IPEKGIDWTFFRENIEGEYIWGNKGIQVDDDL--AVDFKVLTRPGAERICRAAFEFA 209 Query: 184 RKR-RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKD--PSQ 239 + + VT + KAN+++ + + + + EYP + + +D+ ++ Sbjct: 210 KNNGKTNVTVVTKANIVKLVDGNFLKTAHALEKEYPGITVREELVDSMAAKITDQEFTKG 269 Query: 240 FDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKN---IA 296 V L NL+GDI++D A G +G S+++ +Q + L+E G + N A Sbjct: 270 MQVFLLPNLYGDIVTDVAAEYQGGLGTASSSNIGDQ-YALFEAIHGVGNFLVQHNRAQYA 328 Query: 297 NPIAQILSLALLLRY 311 +P + I ++ ++ + Sbjct: 329 DPCSLIRAMGEMISH 343 >UniRef50_Q8KH40 LeuB (Fragment) n=3 Tax=Buchnera aphidicola RepID=Q8KH40_9ENTR Length = 95 Score = 82.8 bits (203), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 44/78 (56%), Positives = 58/78 (74%), Gaps = 1/78 (1%) Query: 280 YEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDL 339 YEPAGGSAPDIAGKNIANPIAQILS+A+L+RY++ + IE A+ L++G RT D+ Sbjct: 11 YEPAGGSAPDIAGKNIANPIAQILSIAMLVRYTMKLPIISDQIESAVIDTLKKGYRTLDI 70 Query: 340 ARGAAAV-STDEMGDIIA 356 A ST+++GDII+ Sbjct: 71 ANDKEKCESTNDIGDIIS 88 >UniRef50_C0W9Q2 Isocitrate dehydrogenase n=2 Tax=Clostridiales RepID=C0W9Q2_9FIRM Length = 387 Score = 82.4 bits (202), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 75/291 (25%), Positives = 129/291 (44%), Gaps = 37/291 (12%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDN---HGQPLPPATVE 63 + ++PGDGIGP +M AL V + + + G I+ + LPPA +E Sbjct: 40 VGIMPGDGIGPYIMKAALLVARKLLKKEIADQRVEFVPIKGMTIEERARQNKSLPPAVLE 99 Query: 64 GCEQADAVLFGSV----GGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEA 119 C+ D ++ G G +W +L A LR+ +L++ +RP + Sbjct: 100 ACKACDILVKGPFVTPRAGDRWPNL-------LSANSLLRRQLQLYAAVRPIR------- 145 Query: 120 FCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIA 179 I G D RE G Y KG A D ++ + ER+ R A Sbjct: 146 -------IPEKGIDWTFFRENIEGEYIWGNKGICVGDDL--AIDFKILSKPGAERLFRNA 196 Query: 180 FESARKR-RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDP 237 FE A+ + +T KAN+++ + ++ + + EYP + + ID+ + +L+ DP Sbjct: 197 FEYAKSSGKTNITVATKANIVKLVDGNFLKVAHAMEKEYPGIHVREELIDSLSAKLM-DP 255 Query: 238 ---SQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGG 285 + V + NL+GDIL+D A G +G S+++ +Q + ++E G Sbjct: 256 EFNAGMQVFVLPNLYGDILTDIAAEYQGGLGTASSSNIGDQ-YAMFEAIHG 305 >UniRef50_B7UV18 Isocitrate dehydrogenase [NADP] n=9 Tax=Gammaproteobacteria RepID=B7UV18_PSEA8 Length = 418 Score = 82.0 bits (201), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 108/408 (26%), Positives = 176/408 (43%), Gaps = 70/408 (17%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRF---AMRITTSHYDVGGAAIDNHGQP--L 57 KN I + GDGIG ++ +KV+DA + +I G A + Q L Sbjct: 27 KNPIIPFIEGDGIGVDISPVMIKVVDAAVEKAYKGERKIAWMEVYAGEKATQVYDQDTWL 86 Query: 58 PPATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGL 117 P T++ D V+ S+ GP P R + LR+ L+ RP + ++G+ Sbjct: 87 PQETLDAVR--DYVV--SIKGP---LTTPVGGGIRSLNVALRQQLDLYVCQRPVRWFEGV 139 Query: 118 EAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKA--FDTEVYH----RFE 171 + D+ D++ RE + IY G + + GS + EK F TE RF Sbjct: 140 PSPVKKPGDV-----DMVIFRENSEDIYAGV-EWKAGSPEAEKVIKFLTEEMGVKKIRFT 193 Query: 172 --------------IERIARIAFESARKR-RHKVTSIDKANVLQ---------------- 200 +R+ R A + A R VT + K N+++ Sbjct: 194 ENCGIGIKPVSQEGTKRLVRKALQYAVDNDRSSVTLVHKGNIMKFTEGAFKDWGYEVARD 253 Query: 201 ---SSIL----WREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDIL 253 + +L W + N + +V + + D Q++ P+++DV+ NL GD L Sbjct: 254 EFGAELLDGGPWMQFKNPKTGK--NVVVKDVIADAMLQQILLRPAEYDVIATLNLNGDYL 311 Query: 254 SDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSL 313 SD A G +G+ P A+L++ ++E G+AP AG++ NP + ILS ++LR+ + Sbjct: 312 SDALAAEVGGIGIAPGANLSDS-VAMFEATHGTAPKYAGQDKVNPGSLILSAEMMLRH-M 369 Query: 314 DADDAACAIERAINRALEEGIRTGDLAR---GAAAVSTDEMGD-IIAR 357 +AA I + N A+ T D R GA +S E GD +IA+ Sbjct: 370 GWTEAADLIIKGTNGAIAAKTVTYDFERLMDGATLLSCSEFGDAMIAK 417 >UniRef50_C7GAF7 3-isopropylmalate dehydrogenase (Fragment) n=1 Tax=Roseburia intestinalis L1-82 RepID=C7GAF7_9FIRM Length = 115 Score = 82.0 bits (201), Expect = 3e-14, Method: Composition-based stats. Identities = 49/112 (43%), Positives = 65/112 (58%), Gaps = 5/112 (4%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCE 66 I V+ GDGIGPE++ +A KVLD + ++ +GG +ID G PL + + Sbjct: 5 IGVISGDGIGPEIVAEAKKVLDKIGTKYGHSFLYEAILMGGCSIDATGVPLTDEAIAAAK 64 Query: 67 QADAVLFGSVGG----PKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLY 114 +DAVL GS+GG W L P+ +PE G LL LRK LF+NLRPA LY Sbjct: 65 ASDAVLMGSIGGNTATSPWYKLAPELRPEAG-LLKLRKSLNLFANLRPAYLY 115 >UniRef50_B1VH60 Putative dehydrogenase n=1 Tax=Corynebacterium urealyticum DSM 7109 RepID=B1VH60_CORU7 Length = 378 Score = 81.6 bits (200), Expect = 4e-14, Method: Compositional matrix adjust. Identities = 105/350 (30%), Positives = 167/350 (47%), Gaps = 24/350 (6%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLD-AVRNRFAMRITTSHYDVGGAAIDNHGQPLPPA 60 ++ + V G+GIGPE++ ++ ++ A++ +G AI+ G+ +P Sbjct: 4 TETCRLGVWQGEGIGPEIVAPTVQAVELALQASGEATPEFVPLLLGREAINATGRIVPEE 63 Query: 61 TVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAF 120 T E D + G + PP + LRK L++N+RP + G A Sbjct: 64 TWETITGLDGWILGPHDNVSY---PPSVAGQLNPSAHLRKQADLWANIRPVRGVPG--AV 118 Query: 121 CPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQY----EKAFDTEVYHRFEIERIA 176 P D++ VRE T G+Y + GSG E + V+ + +I RI Sbjct: 119 HP--------DLDVVIVRENTEGMYADR-NMLMGSGDITVNGEVSLAIGVFTQTKIRRIV 169 Query: 177 RIAFESARKRRHKVTSIDKANVL-QSSILWREIVNEIATEYPDVELAHMYIDNATMQLIK 235 R A A R +T K+NVL ++S + A E+ VE+ ++ID +L+ Sbjct: 170 RRAAAIAAARDGVLTVAHKSNVLTETSGRYVAEAKACAEEF-GVEVQPVHIDALCAELVT 228 Query: 236 DPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNI 295 P ++ ++ N+FGDILSD + GS+G+ S + +E + + A GSAPDIAG+ I Sbjct: 229 RPERYATIVAENMFGDILSDLAGGLGGSLGIAGSINASESQV-MAQAAHGSAPDIAGQGI 287 Query: 296 ANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAA 345 ANP A I++ A + SL AA +E A+ A+ + T DL R AAA Sbjct: 288 ANP-AGIMNSAAQMLDSLGYPQAAELLEGAVREAVVKA-PTADLVREAAA 335 >UniRef50_B6QRT7 3-isopropylmalate dehydrogenase, putative n=1 Tax=Penicillium marneffei ATCC 18224 RepID=B6QRT7_PENMQ Length = 158 Score = 81.3 bits (199), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 47/136 (34%), Positives = 75/136 (55%), Gaps = 4/136 (2%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDA-VRNRFAMRITTSHYDVGGAAIDNHGQPLPP 59 M++ + VL GD IGPE++ +ALK L V R ++ + + GA++D +P+ Sbjct: 1 MAEIRKLLVLRGDRIGPEIIAEALKPLTVLVEERPDFKVQVRYGLLAGASLDKTNEPITD 60 Query: 60 ATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLY-QGLE 118 ++ DAVL GSVG P+W H+P PE+G +L LR+ F+N+RP + L Sbjct: 61 KVLDAALATDAVLLGSVGEPEWAHMPGALNPEKG-ILRLRQRLDAFANIRPCRFCASSLV 119 Query: 119 AFCPLRADIAANGFDI 134 PL++D+ NG + Sbjct: 120 EQSPLKSDM-VNGVNF 134 >UniRef50_Q84AT8 LeuB (Fragment) n=1 Tax=Buchnera aphidicola RepID=Q84AT8_9ENTR Length = 81 Score = 78.6 bits (192), Expect = 3e-13, Method: Composition-based stats. Identities = 40/74 (54%), Positives = 55/74 (74%), Gaps = 1/74 (1%) Query: 284 GGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLAR-G 342 GGSAPDIAGKNIANPIAQILS+A+L+RY++ A IE ++ AL++G +T D+A Sbjct: 1 GGSAPDIAGKNIANPIAQILSIAMLVRYTMKLHKIADDIESSVIDALKKGYKTLDIANVN 60 Query: 343 AAAVSTDEMGDIIA 356 +ST +MGD+I+ Sbjct: 61 ETHISTSDMGDVIS 74 >UniRef50_Q03UU7 3-isopropylmalate dehydrogenase n=4 Tax=Leuconostoc mesenteroides RepID=Q03UU7_LEUMM Length = 308 Score = 77.0 bits (188), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 65/279 (23%), Positives = 122/279 (43%), Gaps = 13/279 (4%) Query: 5 YHIAVLPGDGIGPEVMTQALKVL-DAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 Y +A+L GD V+ +AL ++ +V + A +T + V G + +PLP T+ Sbjct: 2 YKLAILKGDKESSSVIDRALGIIKSSVNDSTAFEVTELPFGVNGVL--SFNEPLPNQTLR 59 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPE-RGALLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 + D +L G++ + + D + +L+ LRK+ + + ++ P Sbjct: 60 ELKNYDGILVGALN----QEVGTDSLLSVQESLVALRKYLNITLACKAVQISDNNVDASP 115 Query: 123 LRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFES 182 L+ I + D + V+ G + A DT Y + E+E++ FE Sbjct: 116 LKNQIVRDT-DFIIVQSAKRA--NDHVDGNISVDDF--AQDTITYEQREVEQVITAGFER 170 Query: 183 ARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDV 242 A R+ VT + + +S +W +IA YPDV + ++ + +I+ P+ DV Sbjct: 171 AMNRKRAVTVVTPFDSFYTSKIWALTAEKIAKIYPDVVVNYVSLSCVISTIIQQPTSLDV 230 Query: 243 LLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYE 281 ++ +L++E ITG +P + N G LY+ Sbjct: 231 VVAPKWVDQVLNEESQKITGLPETVPVSMKNNSGQMLYQ 269 >UniRef50_B5RJP2 FI08066p (Fragment) n=18 Tax=Sophophora RepID=B5RJP2_DROME Length = 408 Score = 75.9 bits (185), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 82/344 (23%), Positives = 144/344 (41%), Gaps = 44/344 (12%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATV 62 K + ++ G+G+G E+M +V+ AV+ +DV + P + Sbjct: 85 KTTKVTLINGEGVGRELMDAVQEVICAVKAPI-------EWDVHDEFKAKDSDDVSPEVL 137 Query: 63 EGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 + + G V W+ +RK F F+ + +GL Sbjct: 138 KSLRANKVGIKGPVDSRHWQR-------------QIRKQFAQFAYVSLCSHIEGL----- 179 Query: 123 LRADIAANGFDILCVRELTGGIYFG-QPKGREGSGQYEKAFDTEVYHRFEIERIARIAFE 181 D FD++ +R+ G Y G + G Q K T RIA F Sbjct: 180 ---DSPYGDFDVVIIRDQMEGDYSGIEHLVVPGVMQTIKVSTTA-----GAARIAEFVFN 231 Query: 182 SARK-RRHKVTSIDKANVLQSS--ILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPS 238 A K +R ++T KAN+++ + + E DV Y+D ++++ P Sbjct: 232 YAVKNKRKRITVAHKANIMRMTDGNFLEAMRAEADKHVDDVLFEERYLDTCILKILLKPH 291 Query: 239 QFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANP 298 + DV++ S+++GD+L + G G+ P S++ G +++ + +AGK++ANP Sbjct: 292 KCDVMVSSSMYGDVLRVIAGGMMGVPGICPGYSVSSLG-TVFDCRMKACHALAGKDLANP 350 Query: 299 IAQILSLALLLRY-SLD--ADDAACAIERAINRALEEGIRTGDL 339 +LS AL+LR+ +D AD CAI + + IRT D+ Sbjct: 351 TGPLLSAALMLRHVKMDKQADQVDCAIRKVYK---DTDIRTPDV 391 >UniRef50_UPI00017936A6 PREDICTED: similar to isocitrate dehydrogenase, NAD-dependent n=1 Tax=Acyrthosiphon pisum RepID=UPI00017936A6 Length = 423 Score = 72.0 bits (175), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 82/365 (22%), Positives = 150/365 (41%), Gaps = 59/365 (16%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAI----DNHGQPLPPATV 62 + V+ G G GP VL AVR F + +D ++ + + P + Sbjct: 43 VTVIEGQGTGP-------VVLAAVRKIFKAALVPVEWDYQTLSVYRDHKTNRMTVNPQLL 95 Query: 63 EGCEQADAVLFGSVGGPKW-EHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 + + VL P+ + L D L L K F +R G E + Sbjct: 96 DSAIETGLVLCAKDSSPRQNDSLESDS-------LALHKALNAFVGVRKFNSVVGHEPYG 148 Query: 122 PLRADIAANGFDILCVRELTGGIY-----FGQPKGREGSGQYEKAFDTEVYHRFEIERIA 176 P+ +++ +RE G Y P + K EV A Sbjct: 149 PI---------NLVNIREHVSGEYSEIEHLVSPGVVQSIKTVSKKISVEV---------A 190 Query: 177 RIAFESARKRRH-KVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLI 234 ++AF+ A K H ++T + KA+V++ S ++ + E++ YPDVE +D+ + + Sbjct: 191 KLAFDYACKHGHSRITVLHKADVMRLSDGIFLKACREVSACYPDVEYNEEKLDSFCLNVT 250 Query: 235 KDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPS----------ASLNEQGFGLYEPAG 284 +P +++VLL ++L+G C M++G + +P+ +++ + G+ Y + Sbjct: 251 TNPGRYEVLLTTSLYGAFAGSVCGMMSGGLVTVPTIAYGPKATVFSTMGDYGYSTYSHSD 310 Query: 285 GSA---PDIAGK-NIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLA 340 G + G+ I NP I + AL+L ++ C I A+ + +GIRT D+ Sbjct: 311 GDGIFKKMVYGQEQIINPTGIIRAAALMLDHAGMVVAGRC-IAAAVEDTIRQGIRTQDMG 369 Query: 341 RGAAA 345 A+ Sbjct: 370 GDASC 374 >UniRef50_Q961P4 GH13226p n=4 Tax=Drosophila RepID=Q961P4_DROME Length = 307 Score = 71.2 bits (173), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 67/249 (26%), Positives = 114/249 (45%), Gaps = 24/249 (9%) Query: 98 LRKHFKLFSNLRPAKLYQGLEAFCPLRADIAANGFDILCVRELTGGIYFG-QPKGREGSG 156 +RK F F+ + +GL D FD++ +R+ G Y G + G Sbjct: 59 IRKQFAQFAYVSLCSHIEGL--------DSPYGDFDVVIIRDQMEGDYSGIEHLVVPGVM 110 Query: 157 QYEKAFDTEVYHRFEIERIARIAFESARK-RRHKVTSIDKANVLQSSI--LWREIVNEIA 213 Q K T RIA F A K +R ++T KAN+++ + + E Sbjct: 111 QTIKVSTTA-----GAARIAEFVFNYAVKNKRKRITVAHKANIMRMTDGNFLEAMRAEAD 165 Query: 214 TEYPDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLN 273 DV Y+D ++++ P + DV++ S+++GD+L + G G+ P S++ Sbjct: 166 KHVDDVLFEERYLDTCILKILLKPHKCDVMVSSSMYGDVLRVIAGGMMGVPGICPGYSVS 225 Query: 274 EQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRY-SLD--ADDAACAIERAINRAL 330 G +++ + +AGK++ANP +LS AL+LR+ +D AD CAI + Sbjct: 226 SLG-TVFDCRMKACHALAGKDLANPTGPLLSAALMLRHVKMDKQADQVDCAIRKVYK--- 281 Query: 331 EEGIRTGDL 339 + IRT D+ Sbjct: 282 DTDIRTPDV 290 >UniRef50_B7KHW3 Isocitrate/isopropylmalate dehydrogenase n=11 Tax=Bacteria RepID=B7KHW3_CYAP7 Length = 363 Score = 67.4 bits (163), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 67/224 (29%), Positives = 104/224 (46%), Gaps = 13/224 (5%) Query: 146 FGQPKGREGSGQ-YEKAFDTEVYHRFEIERIARIAFESARKRRHKVTSIDKANVLQS-SI 203 +G + RE + E A+ T R +A F+ A++ + KV K V + Sbjct: 131 YGSKEWRETTENGDEIAYRTSKISRSTCRAVAEFTFQYAKRTKAKVFGGPKFTVSATYEG 190 Query: 204 LWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGS 263 +++E ++ A YP+V + ID L++ + V+ N GD+LSD + GS Sbjct: 191 MFKEELDAAAKRYPEVPYQPLLIDATFALLLQTTGESLVIPALNRDGDLLSDMVLQMYGS 250 Query: 264 MGMLPSASLN-EQGFG-----LYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSL--DA 315 + S L E G + E G+AP + GKNIANP+A IL+ A LL Y A Sbjct: 251 IAGSESLVLGFESGSDQVKTVMAEAPHGTAPALFGKNIANPMAMILAGAALLSYGRIPQA 310 Query: 316 DDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYV 359 + A+ AI ++ + EG T DL ++T E D + R V Sbjct: 311 EKASRAIYESVFETIYEGKATPDL---GGQMTTSEFTDEVIRRV 351 >UniRef50_C1GSN2 3-isopropylmalate dehydrogenase n=4 Tax=Onygenales RepID=C1GSN2_PARBA Length = 542 Score = 67.4 bits (163), Expect = 8e-10, Method: Compositional matrix adjust. Identities = 41/102 (40%), Positives = 58/102 (56%), Gaps = 11/102 (10%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYD-----VGGAAIDNHGQPLP 58 + I VL GDGIG E+ +A+KVL A F+++ T +D + G +ID G P+ Sbjct: 362 THTILVLRGDGIGLEITAEAVKVLSA----FSLKKRT--FDLRSELIDGCSIDTDGTPIT 415 Query: 59 PATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRK 100 ++ +DAVLF SVGGPKW+ + D + G LL LRK Sbjct: 416 KTVIQAALDSDAVLFASVGGPKWDGVRHDLEGPEGGLLQLRK 457 >UniRef50_UPI0001C163C2 Isocitrate dehydrogenase NADP-dependent, prokaryotic n=3 Tax=Nostocaceae RepID=UPI0001C163C2 Length = 474 Score = 65.9 bits (159), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 41/115 (35%), Positives = 64/115 (55%), Gaps = 2/115 (1%) Query: 227 DNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGS 286 D+ Q+ P ++ +L NL GD LSD A I G +GM P A++ + ++E G+ Sbjct: 338 DSIFQQIQTRPDEYSILATMNLNGDYLSDAAAAIVGGLGMGPGANIGDS-CAIFEATHGT 396 Query: 287 APDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLAR 341 AP AG + NP + ILS ++L Y + +AA I+R + ++ +G T DLAR Sbjct: 397 APKHAGLDKINPGSVILSGVMMLEY-MGWQEAADLIKRGLGASIADGKVTYDLAR 450 >UniRef50_B1XUL5 Tartrate dehydrogenase n=1 Tax=Polynucleobacter necessarius subsp. necessarius STIR1 RepID=B1XUL5_POLNS Length = 120 Score = 64.3 bits (155), Expect = 7e-09, Method: Compositional matrix adjust. Identities = 43/118 (36%), Positives = 60/118 (50%), Gaps = 5/118 (4%) Query: 247 NLFGDILSDECAMITGSMGMLPSASLNEQGF--GLYEPAGGSAPDIAGKNIANPIAQI-- 302 N+FGDILSD TG++ + PS S+N +G L+EP GS PDI GK IANPI Q+ Sbjct: 3 NVFGDILSDLGPACTGTIAVAPSGSINPEGKFPSLFEPVHGSTPDIFGKMIANPIGQMAR 62 Query: 303 LSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARG-AAAVSTDEMGDIIARYV 359 + ++ L + AI I + L G L + TD++G IA + Sbjct: 63 FGVGAMILDHLGYPETGKAIFSVIEKVLSSGAGNAPLTPDLGGSAKTDDLGKAIAAAI 120 >UniRef50_UPI0001C31665 isocitrate/isopropylmalate dehydrogenase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C31665 Length = 368 Score = 63.5 bits (153), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 98/377 (25%), Positives = 164/377 (43%), Gaps = 44/377 (11%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPA 60 M + I +L GD G E++ QA++VLD + + +D+ +++N A Sbjct: 1 MPEPLKITILEGDETGQELLDQAVRVLDPEVTGLPLEL--ERFDL---SLENR-----RA 50 Query: 61 TVEGCEQADAVLFGSVG-GPKWEHLPPDQQPERGALLP---LRKHFKLFSNLRPAKLYQG 116 T G A + G G K + P+ + G+ P LR+ +R + G Sbjct: 51 TQNGVVSDAAAAMRTCGFGIKAATITPEGADDVGS--PNRILREEVDGKVIVRTGRRIPG 108 Query: 117 LEAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQY--EKAFDTEVYHRFEIER 174 + IA + I VR Y G + REG E A+ TE R Sbjct: 109 V-------TPIAGVHYPISIVRMAIEDAY-GAKQWREGDAGAADEVAYRTEHVTRSTCRA 160 Query: 175 IARIAFESARKRRHKVTSIDKANVLQSSI---LWREIVNEIATEYPDVELAHMYIDNATM 231 ++ AF +AR + +V K V S + + +E ++ A +PDV + ID Sbjct: 161 VSEYAFRTARAMQARVYGGPKWTV--SPVYEGMLKEEMDAAAARHPDVAYEPVLIDATYA 218 Query: 232 QLIKDPSQFDVLLCS-NLFGDILSDECAMITGSMGMLPSASLN-----EQGFGLYEPAGG 285 L+ + +++ + N GD LSD + GS+ S L E + E G Sbjct: 219 GLVSGAADEPLVVPALNRDGDCLSDLVLPMFGSIAGAESVLLAFDDNYETHVAMAEAPHG 278 Query: 286 SAPDIAGKNIANPIAQILSLALLLRYSLD-----ADDAACAIERAINRALEEGIRTGDLA 340 +AP + GK++ANP+A +L+ +LR++ + A+ A+ AI ++ A+ GI+T DL Sbjct: 279 TAPALRGKDVANPMAMLLASGAVLRHAAERGHPGAERASRAIYESVLEAIATGIKTPDL- 337 Query: 341 RGAAAVSTDEMGDIIAR 357 G A +T+ +I R Sbjct: 338 -GGHAGTTEFTDAVIER 353 >UniRef50_P41560 Isocitrate dehydrogenase [NADP] 1 n=78 Tax=cellular organisms RepID=IDH1_COLMA Length = 415 Score = 63.5 bits (153), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 97/416 (23%), Positives = 165/416 (39%), Gaps = 94/416 (22%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNR-------------FAMRITTSHYDVGGAAI 50 N I + GDGIG +V LKV++A + +A T YD Sbjct: 26 NPIIPYIEGDGIGVDVTPPMLKVVNAAVAKAYGGDRKIEWLEVYAGEKATKMYD------ 79 Query: 51 DNHGQPLPPATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGAL----LPLRKHFKLFS 106 LP T+ ++ + G P P G + + +R+ L+ Sbjct: 80 --SETWLPEETLNILQEYKVSIKG-----------PLTTPVGGGMSSLNVAIRQMLDLYV 126 Query: 107 NLRPAKLYQGLEAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEV 166 RP + + G+ + +++ D++ RE T IY G + + GS + + + Sbjct: 127 CQRPVQWFTGVPSPVKRPSEV-----DMVIFRENTEDIYAGI-EYKAGSDKAKSVIKFLI 180 Query: 167 YH------RFE--------------IERIARIAFESA-RKRRHKVTSIDKANVLQ-SSIL 204 RF +R+ R A + A + VT + K N+++ + Sbjct: 181 EEMGASNIRFTENCGIGIKPVSKEGSQRLVRQAIQYAIDNNKDSVTLVHKGNIMKFTEGA 240 Query: 205 WREIVNEIATEYPDVELAH--------------------MYIDNATMQLIKDPSQFDVLL 244 +++ E+A E L H + D Q++ P+++ V+ Sbjct: 241 FKDWGYELAIEEFGASLLHGGPWCSLKNPNTGKEIIIKDVIADAMLQQVLLRPAEYSVIA 300 Query: 245 CSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILS 304 NL GD LSD A G +G+ P A+L ++ ++E G+AP AGKN NP + ILS Sbjct: 301 TLNLNGDYLSDALAAQVGGIGIAPGANLGDE-VAVFEATHGTAPKYAGKNKVNPGSVILS 359 Query: 305 LALLLRYS--LDADDAACAIERAINRALEEGIRTGDLAR---GAAAVSTDEMGDII 355 ++LR+ L+AD + + ++ A++ T D R A VS GD I Sbjct: 360 AEMMLRHMGWLEAD----LLLKGMSGAIQAKTVTYDFERLMDDATLVSCSAFGDCI 411 >UniRef50_P80046 Isocitrate dehydrogenase [NADP] n=54 Tax=cellular organisms RepID=IDH_SYNY3 Length = 475 Score = 61.2 bits (147), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 39/115 (33%), Positives = 62/115 (53%), Gaps = 2/115 (1%) Query: 227 DNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGS 286 D+ Q+ P ++ +L NL GD LSD A + G +GM P A++ + ++E G+ Sbjct: 338 DSIFQQIQTRPDEYSILATMNLNGDYLSDAAAAVVGGLGMGPGANIGDSA-AIFEATHGT 396 Query: 287 APDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLAR 341 AP AG + NP + ILS ++L + + +AA I++ I A+ T DLAR Sbjct: 397 APKHAGLDRINPGSVILSGVMMLEF-MGWQEAADLIKKGIGAAIANREVTYDLAR 450 >UniRef50_UPI0001AF5761 3-isopropylmalate dehydrogenase n=1 Tax=Pseudomonas syringae pv. oryzae str. 1_6 RepID=UPI0001AF5761 Length = 59 Score = 60.1 bits (144), Expect = 1e-07, Method: Composition-based stats. Identities = 28/54 (51%), Positives = 38/54 (70%), Gaps = 2/54 (3%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHG 54 MSK I +LPGDGIGPE+MT+A+KVL+ ++ + +H +GGAAID HG Sbjct: 8 MSK--QILILPGDGIGPEIMTEAVKVLELANEKYQLGFELTHDVIGGAAIDKHG 59 >UniRef50_Q1G324 Putative uncharacterized protein n=1 Tax=Arabidopsis thaliana RepID=Q1G324_ARATH Length = 130 Score = 58.2 bits (139), Expect = 4e-07, Method: Compositional matrix adjust. Identities = 32/75 (42%), Positives = 45/75 (60%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATV 62 K Y IAVLPGDG+G EV+ A+ VL + + + +GG A+D G PLP T+ Sbjct: 39 KRYTIAVLPGDGVGNEVIPVAVDVLCLAGSLEGIDFSFEELPIGGVALDLVGVPLPKETL 98 Query: 63 EGCEQADAVLFGSVG 77 +Q+DA+L G+VG Sbjct: 99 IRAKQSDALLLGAVG 113 >UniRef50_UPI00003C8595 isocitrate dehydrogenase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI00003C8595 Length = 377 Score = 57.8 bits (138), Expect = 7e-07, Method: Compositional matrix adjust. Identities = 81/346 (23%), Positives = 148/346 (42%), Gaps = 44/346 (12%) Query: 7 IAVLPGDGIGPEVMTQALKVLDA---VRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 I + GDGIGPE+ + V+++ + + + I +G A + G +P +++ Sbjct: 26 IGYIDGDGIGPEITGAMIGVVNSAIELAYQGSRSIEWHKILIGTEAYEKFGTYVPEDSIK 85 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 ++ + ++ + PD+ R LRK L+SN+R K +G+ Sbjct: 86 EIQKMYIAMKSTL------NFMPDK---RDLNTILRKRLGLYSNIRILKYIEGM------ 130 Query: 124 RADIAANGFDIL---CVRELT--GGIYFGQPKG-----REGSGQYEKAF--DTEVY---- 167 DI N F+ L +R+ T I++ + R S Y D+ +Y Sbjct: 131 --DIPVNTFNRLNLTIIRDSTPNSHIFYHSSESTDDLIRFISDNYGLNITPDSGIYMMPQ 188 Query: 168 HRFEIERIARIAFESARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYID 227 +F +IA+ A +R+ K +I ++ W E A+ DV + Sbjct: 189 SKFRTRKIAKQAVRYSRRNGKKKITILESQQNHEFANW---CIEEASAQEDVGYEVLKTR 245 Query: 228 NATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSA 287 +LI P F+V+L N+ L D A G++ + +S+ ++ ++E S Sbjct: 246 EFMKRLISSPEDFEVILVDNVLSQTLVDYLA---GTINIEYGSSIGDEC-AVFEAVQSSL 301 Query: 288 PDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEG 333 P AG + A+P++ ILS +L + + +AA IE AI+ A + Sbjct: 302 PSEAGYDAADPLSFILSGCEMLMH-IGWVEAAQIIENAISAAFRDN 346 >UniRef50_A3RRN5 Tartrate dehydrogenase n=3 Tax=Ralstonia solanacearum RepID=A3RRN5_RALSO Length = 95 Score = 55.5 bits (132), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 29/78 (37%), Positives = 41/78 (52%), Gaps = 1/78 (1%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAID-NHGQPLPPAT 61 +Y IAV+PGDGIG E + + L+V DA RF + H+D + HG+ P Sbjct: 2 SSYRIAVIPGDGIGKEAVPERLRVPDAAARRFGFALHCGHFDFASSDTRARHGKLRPDDR 61 Query: 62 VEGCEQADAVLFGSVGGP 79 + DA+ FG+VG P Sbjct: 62 FDTLRGYDALFFGAVGRP 79 >UniRef50_UPI00017440F3 Isocitrate dehydrogenase (NAD(+)) n=1 Tax=candidate division TM7 single-cell isolate TM7a RepID=UPI00017440F3 Length = 175 Score = 54.3 bits (129), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 38/145 (26%), Positives = 64/145 (44%), Gaps = 19/145 (13%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 I ++PGDGIG E+ +K+ DA + + + + G + G+ +P + E Sbjct: 3 KITLIPGDGIGYEISESLVKIFDAAK----VPVEFETENAGSDVYEKTGELIPESLYESV 58 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 E+ + G + P + R + LRK + L++N R ++ G+E R Sbjct: 59 ERNKIAIKGPITTPIGKGF-------RSINVYLRKKYDLYTNFRSSRNLPGIET----RY 107 Query: 126 DIAANGFDILCVRELTGGIYFGQPK 150 D D+ RE T GIY G+ K Sbjct: 108 D----NIDLAIFRENTEGIYIGEEK 128 >UniRef50_D0WIJ5 Isocitrate dehydrogenase, NADP-dependent n=2 Tax=Bacteria RepID=D0WIJ5_9ACTN Length = 434 Score = 53.1 bits (126), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 53/190 (27%), Positives = 83/190 (43%), Gaps = 21/190 (11%) Query: 172 IERIARIAFESARKRRHKVTSIDKANVLQS-SILWREIVNEIAT-------EYPDVELAH 223 IE AR F+ A V K + ++ +++I EI E +E + Sbjct: 219 IESFARACFDFALATSQDVWFATKDTISKTYDHRFKDIFQEIFDADYAARFEAAGIEYFY 278 Query: 224 MYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPA 283 ID+A +++K F + C N GD++SD + GS+ M+ S + G+ YE A Sbjct: 279 TLIDDAVARVMKAEGGF-IWACKNYDGDVMSDMVSSAFGSLAMMTSVLASPHGYWEYEAA 337 Query: 284 GGSAPDIAGKNIA------NPIAQILSLALLLRYSLDAD------DAACAIERAINRALE 331 G+ K++A N +A I + LR + D A A+E+A +E Sbjct: 338 HGTVQRHYYKHLAGEETSTNSVATIFAWTGALRKRAELDGLADLAAFADALEQATVATIE 397 Query: 332 EGIRTGDLAR 341 G TGDLAR Sbjct: 398 SGKMTGDLAR 407 >UniRef50_B5DZV4 GA24694 n=6 Tax=Drosophila RepID=B5DZV4_DROPS Length = 395 Score = 48.1 bits (113), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 41/170 (24%), Positives = 86/170 (50%), Gaps = 10/170 (5%) Query: 172 IERIARIAFESA-RKRRHKVTSIDKAN---VLQSSILWREIVNEI-ATEYPDVELAHMYI 226 + + R AFE+A R R +VT I KAN V +++ EI ++ A +Y ++L M + Sbjct: 199 VTKYLRHAFEAAIRAGRCRVTLIHKANEWPVTDGAMV--EIAEKMHAEDYCSIKLELMEL 256 Query: 227 DNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGS 286 D+ +LI DP+ FD + ++ + L+ C+ + G + + L + +++P + Sbjct: 257 DDCVNRLITDPAYFDTIFTNDRYATFLATICSGVAGGANLFSAIELGD-SHAVFKPL-QT 314 Query: 287 APDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRT 336 + ++ +P I+S + L + + A ++ + + R + +GI+T Sbjct: 315 KLSLTNYSLLSPYG-IVSTCVDLLNHVGQESCAKSLWKGMLRTMTDGIKT 363 >UniRef50_D0DDP2 3-isopropylmalate dehydrogenase n=1 Tax=Citreicella sp. SE45 RepID=D0DDP2_9RHOB Length = 81 Score = 47.8 bits (112), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 22/31 (70%), Positives = 26/31 (83%) Query: 279 LYEPAGGSAPDIAGKNIANPIAQILSLALLL 309 ++EPA GSAPDIAG+NIANPIA I S A +L Sbjct: 1 MFEPAHGSAPDIAGRNIANPIAAIWSGAQML 31 >UniRef50_B6QD56 Putative uncharacterized protein n=1 Tax=Penicillium marneffei ATCC 18224 RepID=B6QD56_PENMQ Length = 106 Score = 46.6 bits (109), Expect = 0.001, Method: Compositional matrix adjust. Identities = 26/78 (33%), Positives = 41/78 (52%), Gaps = 1/78 (1%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAM-RITTSHYDVGGAAIDNHGQPLPPAT 61 K Y IA +PGD IGPEV+ + VL +++ + R+ + D G A G+ +P Sbjct: 7 KTYKIASIPGDDIGPEVVNVIIDVLKSLQEILSTYRLEFTELDWGTARYKRTGKYMPADG 66 Query: 62 VEGCEQADAVLFGSVGGP 79 + + A +FG+VG P Sbjct: 67 LSTLKTFHAGIFGAVGAP 84 >UniRef50_Q8T494 AT08722p n=1 Tax=Drosophila melanogaster RepID=Q8T494_DROME Length = 218 Score = 43.9 bits (102), Expect = 0.009, Method: Compositional matrix adjust. Identities = 44/173 (25%), Positives = 77/173 (44%), Gaps = 12/173 (6%) Query: 173 ERIARIAFESARKR-RHKVTSIDKAN---VLQSSILWREIVNEIATEYPDVELAHMYIDN 228 ++ R AF++A K R +VT I+KA + S++ E + Y D + Sbjct: 28 DKYLRYAFKAAAKAGRKRVTLINKAKEWPISDGSLV--EAAQRLHCHYKDCLELELMEVE 85 Query: 229 -ATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSA 287 A +L+ +P+ FD L S + LS C+ + G + + + + +++P Sbjct: 86 EAISRLMTEPTYFDCLFASERYATFLSAICSGVCGGANLFSAVEIGDH-HAVFKPL---Q 141 Query: 288 PDIAGKNIANPIAQ-ILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDL 339 ++ N AN A I+S + L L D A A+ + R + EGIRT + Sbjct: 142 TKLSLTNYANLSAYGIVSTIVDLFQHLGHDKCADALWCELKRTMNEGIRTKEF 194 >UniRef50_A4SBK5 Predicted protein n=6 Tax=Eukaryota RepID=A4SBK5_OSTLU Length = 409 Score = 42.4 bits (98), Expect = 0.027, Method: Compositional matrix adjust. Identities = 43/155 (27%), Positives = 75/155 (48%), Gaps = 19/155 (12%) Query: 220 ELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPS--ASLNEQGF 277 EL H+ D ATM+L++ + N GD+L+DE A I S G + S ++E G Sbjct: 253 ELVHLLSDAATMKLVQWRQGGFGMAAHNYDGDVLTDELAQIHKSPGFITSNLVGVDENGT 312 Query: 278 GL--YEPAGGSAPD-----IAGKNIA-NPIAQILSLALLLRYSLDADD-------AACAI 322 + +E + G+ D + G+ + NP+ + L + ++ D + A A Sbjct: 313 LIKEFEASHGTVADMDEARLRGEETSLNPLGMVEGLIGAMNHAADVHNVDKERTLAFTAK 372 Query: 323 ERA-INRALEEGIRTGDLARGAAAVSTDEMGDIIA 356 RA I++ EG T DL+ G + ++T++ D +A Sbjct: 373 MRAVIHQLFREGKGTRDLS-GPSGLTTEQFVDAVA 406 >UniRef50_Q7X199 Lfe195p1 (Fragment) n=4 Tax=Leptospirillum RepID=Q7X199_9BACT Length = 197 Score = 42.4 bits (98), Expect = 0.028, Method: Compositional matrix adjust. Identities = 28/73 (38%), Positives = 40/73 (54%), Gaps = 3/73 (4%) Query: 285 GSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAA 344 GSAP AG NP A +LS ++L++ L+ +AA IE+ +++ L E A G A Sbjct: 6 GSAPKYAGMKKVNPSAVLLSGVMMLKW-LNEHEAATRIEKGVDKVLAEAKHLTYDAGGTA 64 Query: 345 AVSTDEMGDIIAR 357 STDE D I + Sbjct: 65 --STDEYADAIIK 75 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_Q4QLS3 3-isopropylmalate dehydrogenase n=43 Tax=Bacteri... 484 e-135 UniRef50_Q47WG3 3-isopropylmalate dehydrogenase n=20 Tax=Bacteri... 460 e-128 UniRef50_Q9WZ26 3-isopropylmalate dehydrogenase n=47 Tax=Bacteri... 452 e-126 UniRef50_Q493R1 3-isopropylmalate dehydrogenase n=224 Tax=Bacter... 448 e-124 UniRef50_D1HRU7 3-isopropylmalate dehydrogenase (Fragment) n=2 T... 434 e-120 UniRef50_Q9FMT1 3-isopropylmalate dehydrogenase 3, chloroplastic... 415 e-115 UniRef50_C9KJM9 3-isopropylmalate dehydrogenase n=1 Tax=Mitsuoke... 413 e-114 UniRef50_Q6GF15 3-isopropylmalate dehydrogenase n=94 Tax=Bacilli... 408 e-112 UniRef50_Q5SIY4 3-isopropylmalate dehydrogenase n=53 Tax=cellula... 398 e-109 UniRef50_Q5HMF8 3-isopropylmalate dehydrogenase n=9 Tax=Bacilli ... 396 e-109 UniRef50_Q81G11 3-isopropylmalate dehydrogenase n=105 Tax=Bacter... 392 e-108 UniRef50_D0J9Z6 3-isopropylmalate dehydrogenase n=7 Tax=Bacteroi... 388 e-106 UniRef50_Q2YL58 3-isopropylmalate dehydrogenase n=285 Tax=cellul... 387 e-106 UniRef50_Q4FP17 3-isopropylmalate dehydrogenase n=11 Tax=cellula... 386 e-106 UniRef50_Q2J3B4 3-isopropylmalate dehydrogenase n=132 Tax=Bacter... 386 e-106 UniRef50_B1I496 3-isopropylmalate dehydrogenase n=4 Tax=Bacteria... 385 e-105 UniRef50_O29627 3-isopropylmalate dehydrogenase n=91 Tax=cellula... 381 e-104 UniRef50_Q5LAB4 3-isopropylmalate dehydrogenase n=58 Tax=Bacteri... 381 e-104 UniRef50_Q46NL2 Tartrate dehydrogenase n=12 Tax=Bacteria RepID=Q... 380 e-104 UniRef50_Q2K2V0 3-isopropylmalate dehydrogenase n=11 Tax=Alphapr... 378 e-103 UniRef50_Q55BI2 Isocitrate dehydrogenase [NAD] regulatory subuni... 378 e-103 UniRef50_Q2VZV2 3-isopropylmalate dehydrogenase n=35 Tax=Bacteri... 376 e-103 UniRef50_A3P147 Tartrate dehydrogenase n=59 Tax=Bacteria RepID=A... 376 e-103 UniRef50_A4IK21 Tartrate dehydrogenase n=7 Tax=Bacillaceae RepID... 375 e-102 UniRef50_Q2RV53 3-isopropylmalate dehydrogenase n=103 Tax=Bacter... 374 e-102 UniRef50_O27441 3-isopropylmalate dehydrogenase n=30 Tax=Archaea... 374 e-102 UniRef50_Q46FW0 3-isopropylmalate dehydrogenase n=11 Tax=Euryarc... 373 e-102 UniRef50_Q2JUI3 Isopropylmalate/isohomocitrate dehydrogenase fam... 372 e-101 UniRef50_Q1IJA8 Isocitrate dehydrogenase (NAD+) n=19 Tax=Bacteri... 371 e-101 UniRef50_Q1ARE1 3-isopropylmalate dehydrogenase n=2 Tax=Bacteria... 369 e-100 UniRef50_D2EFL9 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 369 e-100 UniRef50_Q58991 Homoisocitrate dehydrogenase n=21 Tax=Euryarchae... 368 e-100 UniRef50_Q51945 Tartrate dehydrogenase/decarboxylase n=249 Tax=c... 368 e-100 UniRef50_C4Q3D3 Unc-13 (Munc13), putative n=38 Tax=cellular orga... 366 e-100 UniRef50_P42958 Probable tartrate dehydrogenase/decarboxylase n=... 366 e-100 UniRef50_P70787 Probable tartrate dehydrogenase/decarboxylase tt... 365 1e-99 UniRef50_B8N3I6 Tartrate dehydrogenase, putative n=3 Tax=Trichoc... 364 2e-99 UniRef50_B3TCK6 Putative isocitrate/isopropylmalate dehydrogenas... 363 8e-99 UniRef50_Q6W109 Tartrate dehydrogenase n=13 Tax=Bacteria RepID=Q... 359 7e-98 UniRef50_C1XGT6 Homoisocitrate dehydrogenase n=1 Tax=Meiothermus... 358 2e-97 UniRef50_Q5SIJ1 Homoisocitrate dehydrogenase n=13 Tax=cellular o... 358 2e-97 UniRef50_A9IDG2 Tartrate dehydrogenase n=5 Tax=cellular organism... 358 2e-97 UniRef50_P04173 3-isopropylmalate dehydrogenase n=61 Tax=Fungi/M... 358 2e-97 UniRef50_P50213 Isocitrate dehydrogenase [NAD] subunit alpha, mi... 356 6e-97 UniRef50_Q12545 3-isopropylmalate dehydrogenase n=54 Tax=cellula... 353 6e-96 UniRef50_B1MJY2 Tartrate dehydrogenase n=5 Tax=Bacteria RepID=B1... 353 7e-96 UniRef50_Q2JYV7 Probable tartrate dehydrogenase protein n=7 Tax=... 352 1e-95 UniRef50_A1SWV5 3-isopropylmalate dehydrogenase n=1 Tax=Psychrom... 349 8e-95 UniRef50_D0DDG4 3-isopropylmalate dehydrogenase n=1 Tax=Citreice... 348 2e-94 UniRef50_C3MI61 3-isopropylmalate dehydrogenase n=13 Tax=Proteob... 348 2e-94 UniRef50_UPI000150AB37 dehydrogenase, isocitrate/isopropylmalate... 347 3e-94 UniRef50_A5US63 Homoisocitrate dehydrogenase n=6 Tax=Chloroflexi... 346 8e-94 UniRef50_B0ER68 Tartrate dehydrogenase, putative n=2 Tax=Entamoe... 346 1e-93 UniRef50_B9KYU3 Isocitrate dehydrogenase (NADP) n=3 Tax=Bacteria... 345 1e-93 UniRef50_P34738 3-isopropylmalate dehydrogenase n=8 Tax=cellular... 345 2e-93 UniRef50_UPI0001C310FF Tartrate decarboxylase n=1 Tax=Conexibact... 345 2e-93 UniRef50_Q0D0R7 Isocitrate dehydrogenase subunit 2, mitochondria... 345 2e-93 UniRef50_A5CDH3 Isocitrate dehydrogenase, NADP-dependent n=7 Tax... 344 2e-93 UniRef50_UPI0001B4F4BD putative isocitrate/isopropylmalate dehyd... 344 2e-93 UniRef50_P33197 Isocitrate dehydrogenase [NADP] n=10 Tax=Bacteri... 343 5e-93 UniRef50_Q0W5L4 3-isopropylmalate dehydrogenase n=14 Tax=root Re... 343 6e-93 UniRef50_A5UMS5 3-isopropylmalate dehydrogenase, LeuB n=8 Tax=Eu... 340 5e-92 UniRef50_Q47SB4 3-isopropylmalate dehydrogenase n=15 Tax=cellula... 339 8e-92 UniRef50_A6WAX5 3-isopropylmalate dehydrogenase n=20 Tax=Bacteri... 337 3e-91 UniRef50_P40495 Homoisocitrate dehydrogenase, mitochondrial n=66... 337 3e-91 UniRef50_D0RN50 Threo-isocitrate dehydrogenase [NAD] n=1 Tax=alp... 337 4e-91 UniRef50_O59930 3-isopropylmalate dehydrogenase n=12 Tax=cellula... 337 5e-91 UniRef50_D0LNY3 3-isopropylmalate dehydrogenase n=1 Tax=Haliangi... 336 8e-91 UniRef50_Q1RJU4 Isocitrate dehydrogenase [NADP] n=62 Tax=cellula... 335 1e-90 UniRef50_A8TPC9 3-isopropylmalate dehydrogenase n=3 Tax=Alphapro... 335 1e-90 UniRef50_Q7UTP0 3-isopropylmalate dehydrogenase n=1 Tax=Rhodopir... 334 3e-90 UniRef50_B1L3C1 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 330 6e-89 UniRef50_A9QPI0 Isocitrate/isopropylmalate dehydrogenase n=3 Tax... 329 6e-89 UniRef50_B0RIP4 3-isopropylmalate dehydrogenase n=140 Tax=Bacter... 328 2e-88 UniRef50_C7RJH9 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 328 2e-88 UniRef50_Q05FQ8 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 327 3e-88 UniRef50_Q0BQF4 Isocitrate dehydrogenase (NADP) n=14 Tax=Proteob... 327 3e-88 UniRef50_B8M3W0 3-isopropylmalate dehydrogenase n=6 Tax=Leotiomy... 327 5e-88 UniRef50_C1F3J9 Isocitrate dehydrogenase n=1 Tax=Acidobacterium ... 327 5e-88 UniRef50_O81796 Isocitrate dehydrogenase [NAD] regulatory subuni... 325 2e-87 UniRef50_P28241 Isocitrate dehydrogenase [NAD] subunit 2, mitoch... 322 8e-87 UniRef50_Q8XSY8 Probable 3-isopropylmalate dehydrogenase oxidore... 322 8e-87 UniRef50_D2VFR4 Homo-isocitrate dehydrogenase n=1 Tax=Naegleria ... 322 9e-87 UniRef50_A5FXZ9 3-isopropylmalate dehydrogenase n=2 Tax=Alphapro... 322 1e-86 UniRef50_P41564 Isocitrate dehydrogenase [NAD] subunit gamma, mi... 322 1e-86 UniRef50_A9FME3 3-isopropylmalate dehydrogenase n=7 Tax=Proteoba... 321 3e-86 UniRef50_D1B742 3-isopropylmalate dehydrogenase n=2 Tax=Synergis... 320 5e-86 UniRef50_P51553 Isocitrate dehydrogenase [NAD] subunit gamma, mi... 320 6e-86 UniRef50_Q4ZRW7 3-isopropylmalate dehydrogenase n=13 Tax=Proteob... 320 6e-86 UniRef50_C7MQT6 Isocitrate/isopropylmalate dehydrogenase n=1 Tax... 319 1e-85 UniRef50_A7SJV9 Predicted protein n=1 Tax=Nematostella vectensis... 319 1e-85 UniRef50_C4QCG1 Isocitrate dehydrogenase [NAD] subunit gamma, mi... 317 5e-85 UniRef50_A1WHK9 3-isopropylmalate dehydrogenase n=5 Tax=Proteoba... 316 7e-85 UniRef50_C6V444 Isocitrate dehydrogenase n=2 Tax=Neorickettsia R... 316 8e-85 UniRef50_B3RY01 Putative uncharacterized protein n=1 Tax=Trichop... 314 4e-84 UniRef50_D2SEJ6 3-isopropylmalate dehydrogenase n=3 Tax=Actinomy... 313 5e-84 UniRef50_Q4P2R4 3-isopropylmalate dehydrogenase n=1 Tax=Ustilago... 312 1e-83 UniRef50_A0D2B8 Chromosome undetermined scaffold_35, whole genom... 312 2e-83 UniRef50_D2RVT1 Isocitrate dehydrogenase, NADP-dependent n=1 Tax... 312 2e-83 UniRef50_B8NJA6 3-isopropymalate dehydrogenase, putative n=3 Tax... 311 3e-83 UniRef50_C5EHC0 3-isopropylmalate dehydrogenase n=1 Tax=Clostrid... 311 3e-83 UniRef50_B7PN53 Isocitrate dehydrogenase, putative (Fragment) n=... 311 3e-83 UniRef50_UPI0001AF2578 isocitrate dehydrogenase [NADP] (oxalosuc... 310 4e-83 UniRef50_Q0X0C1 Putative dehydrogenase n=2 Tax=Streptomyces RepI... 310 5e-83 UniRef50_B2J8P1 3-isopropylmalate dehydrogenase n=3 Tax=Cyanobac... 310 5e-83 UniRef50_Q5JFV8 Homoisocitrate dehydrogenase n=4 Tax=Thermococca... 309 8e-83 UniRef50_D1B6F8 3-isopropylmalate dehydrogenase n=1 Tax=Thermana... 309 1e-82 UniRef50_O13696 Isocitrate dehydrogenase [NAD] subunit 1, mitoch... 308 2e-82 UniRef50_Q1IMD5 3-isopropylmalate dehydrogenase n=3 Tax=cellular... 307 3e-82 UniRef50_Q5P9Q1 Isocitrate dehydrogenase n=13 Tax=Rickettsiales ... 307 3e-82 UniRef50_A9UQS3 Predicted protein n=1 Tax=Monosiga brevicollis R... 307 3e-82 UniRef50_P28834 Isocitrate dehydrogenase [NAD] subunit 1, mitoch... 307 4e-82 UniRef50_B1L5I7 Isocitrate dehydrogenase (NAD(+)) n=1 Tax=Candid... 306 7e-82 UniRef50_C0WN79 Isocitrate dehydrogenase [NADP] n=4 Tax=Lactobac... 304 3e-81 UniRef50_Q6GG12 Isocitrate dehydrogenase [NADP] n=90 Tax=root Re... 304 4e-81 UniRef50_C7P3E9 Isocitrate dehydrogenase, NADP-dependent n=5 Tax... 303 6e-81 UniRef50_A6G3V7 Probable 3-isopropylmalate dehydrogenase n=2 Tax... 303 7e-81 UniRef50_O43837 Isocitrate dehydrogenase [NAD] subunit beta, mit... 303 8e-81 UniRef50_Q48806 Protein dlpA n=5 Tax=Legionella RepID=DLPA_LEGPH 302 9e-81 UniRef50_Q0ZQ44 FrbE n=1 Tax=Streptomyces rubellomurinus RepID=Q... 302 1e-80 UniRef50_O67480 Isocitrate dehydrogenase [NADP] n=5 Tax=Aquifica... 300 5e-80 UniRef50_P96318 Isocitrate dehydrogenase [NADP] n=5 Tax=cellular... 299 2e-79 UniRef50_UPI00019260EC PREDICTED: similar to predicted protein i... 297 3e-79 UniRef50_Q9U6V3 Isocitrate dehydrogenase gamma subunit n=4 Tax=B... 297 5e-79 UniRef50_A0P1S6 3-isopropylmalate dehydrogenase n=3 Tax=Rhodobac... 292 1e-77 UniRef50_A4WLX6 Isocitrate dehydrogenase (NADP) n=22 Tax=Archaea... 291 2e-77 UniRef50_B7UV18 Isocitrate dehydrogenase [NADP] n=9 Tax=Gammapro... 291 3e-77 UniRef50_A9A2N6 Isocitrate dehydrogenase (NAD(+)) n=11 Tax=Archa... 285 1e-75 UniRef50_Q0A635 Isocitrate/isopropylmalate dehydrogenase n=1 Tax... 284 4e-75 UniRef50_Q9ZN36 Isocitrate dehydrogenase [NADP] n=932 Tax=root R... 282 1e-74 UniRef50_P41560 Isocitrate dehydrogenase [NADP] 1 n=78 Tax=cellu... 279 2e-73 UniRef50_A1WV93 3-isopropylmalate dehydrogenase n=8 Tax=Gammapro... 278 2e-73 UniRef50_Q18GT1 3-isopropylmalate dehydrogenase n=8 Tax=Halobact... 277 5e-73 UniRef50_Q3IKZ8 Isocitrate dehydrogenase, specific for NADP+ n=3... 276 8e-73 UniRef50_D2Y061 Isocitrate dehydrogenase n=1 Tax=Bombyx mori Rep... 276 9e-73 UniRef50_O15384 NAD (H)-specific isocitrate dehydrogenase gamma ... 272 1e-71 UniRef50_UPI000186E03D isocitrate dehydrogenase, putative n=1 Ta... 270 4e-71 UniRef50_A9KQX3 Isocitrate dehydrogenase (NAD(+)) n=5 Tax=cellul... 269 1e-70 UniRef50_UPI000185C11E 3-isopropylmalate dehydrogenase n=1 Tax=C... 268 2e-70 UniRef50_Q2HAA2 Putative uncharacterized protein n=2 Tax=Chaetom... 268 2e-70 UniRef50_C9SEZ4 Homoisocitrate dehydrogenase n=1 Tax=Verticilliu... 265 2e-69 UniRef50_UPI000038E0FC 3-isopropylmalate dehydrogenase n=1 Tax=F... 265 2e-69 UniRef50_D2VM48 Isocitrate dehydrogenase n=1 Tax=Naegleria grube... 264 5e-69 UniRef50_UPI00016C59BF Isocitrate dehydrogenase (NAD+) n=1 Tax=G... 259 9e-68 UniRef50_A9B3D4 Isocitrate/isopropylmalate dehydrogenase n=4 Tax... 259 1e-67 UniRef50_D2RML7 Isocitrate/isopropylmalate dehydrogenase n=6 Tax... 258 3e-67 UniRef50_B5RJP2 FI08066p (Fragment) n=18 Tax=Sophophora RepID=B5... 256 9e-67 UniRef50_B8FQF2 Isocitrate/isopropylmalate dehydrogenase n=2 Tax... 253 1e-65 UniRef50_Q6L0K7 3-isopropylmalate dehydrogenase n=1 Tax=Picrophi... 248 2e-64 UniRef50_C0W9Q2 Isocitrate dehydrogenase n=2 Tax=Clostridiales R... 246 1e-63 UniRef50_C7YX79 Putative uncharacterized protein (Fragment) n=1 ... 237 6e-61 UniRef50_A6GJ83 Isocitrate dehydrogenase n=1 Tax=Plesiocystis pa... 234 4e-60 UniRef50_A4FEJ6 3-isopropylmalate dehydrogenase n=1 Tax=Saccharo... 234 5e-60 UniRef50_D2SD16 Malate/L-lactate dehydrogenase n=1 Tax=Geodermat... 232 2e-59 UniRef50_Q961P4 GH13226p n=4 Tax=Drosophila RepID=Q961P4_DROME 230 6e-59 UniRef50_C5GTE7 Tartrate dehydrogenase n=2 Tax=Ajellomyces derma... 229 1e-58 UniRef50_B4MP27 GK19462 n=1 Tax=Drosophila willistoni RepID=B4MP... 226 1e-57 UniRef50_B0BZF3 Isocitrate dehydrogenase NAD-dependent n=1 Tax=A... 225 2e-57 UniRef50_UPI00017936A6 PREDICTED: similar to isocitrate dehydrog... 223 6e-57 UniRef50_B1VH60 Putative dehydrogenase n=1 Tax=Corynebacterium u... 220 8e-56 UniRef50_UPI0001C31665 isocitrate/isopropylmalate dehydrogenase ... 210 9e-53 UniRef50_B7KHW3 Isocitrate/isopropylmalate dehydrogenase n=11 Ta... 206 1e-51 UniRef50_UPI00003C8595 isocitrate dehydrogenase n=1 Tax=Ferropla... 197 5e-49 UniRef50_B4PZH5 GE17383 n=3 Tax=Drosophila RepID=B4PZH5_DROYA 186 1e-45 UniRef50_UPI0001C163C2 Isocitrate dehydrogenase NADP-dependent, ... 158 2e-37 UniRef50_A8E541 Idh3a protein n=4 Tax=Euteleostomi RepID=A8E541_... 158 4e-37 UniRef50_Q03UU7 3-isopropylmalate dehydrogenase n=4 Tax=Leuconos... 157 6e-37 UniRef50_P80046 Isocitrate dehydrogenase [NADP] n=54 Tax=cellula... 149 1e-34 UniRef50_B5DZV4 GA24694 n=6 Tax=Drosophila RepID=B5DZV4_DROPS 144 5e-33 UniRef50_C7YNU4 Putative uncharacterized protein n=1 Tax=Nectria... 140 6e-32 UniRef50_UPI00017440F3 Isocitrate dehydrogenase (NAD(+)) n=1 Tax... 139 2e-31 UniRef50_A5BNI3 Putative uncharacterized protein n=1 Tax=Vitis v... 133 1e-29 UniRef50_D0WIJ5 Isocitrate dehydrogenase, NADP-dependent n=2 Tax... 129 1e-28 UniRef50_B6QRT7 3-isopropylmalate dehydrogenase, putative n=1 Ta... 116 2e-24 UniRef50_C7GAF7 3-isopropylmalate dehydrogenase (Fragment) n=1 T... 104 4e-21 UniRef50_B1XUL5 Tartrate dehydrogenase n=1 Tax=Polynucleobacter ... 101 3e-20 UniRef50_C1GSN2 3-isopropylmalate dehydrogenase n=4 Tax=Onygenal... 95 3e-18 UniRef50_Q8KH40 LeuB (Fragment) n=3 Tax=Buchnera aphidicola RepI... 91 5e-17 UniRef50_Q1G324 Putative uncharacterized protein n=1 Tax=Arabido... 89 2e-16 UniRef50_Q84AT8 LeuB (Fragment) n=1 Tax=Buchnera aphidicola RepI... 85 5e-15 UniRef50_B6QD56 Putative uncharacterized protein n=1 Tax=Penicil... 83 2e-14 UniRef50_A3RRN5 Tartrate dehydrogenase n=3 Tax=Ralstonia solanac... 80 1e-13 UniRef50_UPI0001AF5761 3-isopropylmalate dehydrogenase n=1 Tax=P... 68 4e-10 UniRef50_UPI0001910A87 3-isopropylmalate dehydrogenase n=1 Tax=S... 64 8e-09 UniRef50_D0DDP2 3-isopropylmalate dehydrogenase n=1 Tax=Citreice... 56 3e-06 Sequences not found previously or not previously below threshold: UniRef50_Q9LQK9 Putative isocitrate dehydrogenase [NAD] subunit-... 157 5e-37 UniRef50_A7T3D9 Predicted protein n=2 Tax=cellular organisms Rep... 128 2e-28 UniRef50_B3MF82 GF11274 n=1 Tax=Drosophila ananassae RepID=B3MF8... 126 1e-27 UniRef50_Q7XZ87 Isocitrate dehydrogenase (Fragment) n=1 Tax=Grif... 119 1e-25 UniRef50_Q0CXI1 Isocitrate dehydrogenase, mitochondrial n=2 Tax=... 113 1e-23 UniRef50_Q0V3G8 Putative uncharacterized protein n=1 Tax=Phaeosp... 109 1e-22 UniRef50_O75874 Isocitrate dehydrogenase [NADP] cytoplasmic n=36... 106 1e-21 UniRef50_P48735 Isocitrate dehydrogenase [NADP], mitochondrial n... 103 1e-20 UniRef50_B6KL81 Isocitrate dehydrogenase, putative n=6 Tax=cellu... 103 2e-20 UniRef50_Q6L1Z1 Isocitrate dehydrogenase [NADP] n=1 Tax=Picrophi... 101 6e-20 UniRef50_P50217 Isocitrate dehydrogenase [NADP] n=49 Tax=cellula... 100 1e-19 UniRef50_A2Q9Q7 Contig An01c0300, complete genome n=6 Tax=Tricho... 95 3e-18 UniRef50_A1D5P0 Isocitrate dehydrogenase family protein n=4 Tax=... 93 2e-17 UniRef50_C5FHL7 Isocitrate dehydrogenase family protein n=1 Tax=... 88 5e-16 UniRef50_Q8T494 AT08722p n=1 Tax=Drosophila melanogaster RepID=Q... 87 1e-15 UniRef50_Q567A6 Isocitrate dehydrogenase 3 (NAD+) gamma n=1 Tax=... 86 2e-15 UniRef50_Q8N9Z6 cDNA FLJ36019 fis, clone TESTI2016421, highly si... 83 2e-14 UniRef50_A4SBK5 Predicted protein n=6 Tax=Eukaryota RepID=A4SBK5... 81 9e-14 UniRef50_A3JDN6 Isocitrate dehydrogenase n=5 Tax=Gammaproteobact... 78 6e-13 UniRef50_Q7X199 Lfe195p1 (Fragment) n=4 Tax=Leptospirillum RepID... 75 4e-12 UniRef50_B9SFA3 NADP-specific isocitrate dehydrogenase, putative... 75 6e-12 UniRef50_B8BX37 Predicted protein n=1 Tax=Thalassiosira pseudona... 72 4e-11 UniRef50_B8KHT3 Isocitrate dehydrogenase, NADP-dependent n=3 Tax... 70 1e-10 UniRef50_A8PW52 Probable isocitrate dehydrogenase, putative n=1 ... 69 2e-10 UniRef50_B8P335 Predicted protein (Fragment) n=4 Tax=Dikarya Rep... 67 1e-09 UniRef50_B5G7Q5 Truncated isocitrate dehydrogenase family protei... 63 2e-08 UniRef50_UPI0001792E94 PREDICTED: similar to AGAP007786-PA n=1 T... 62 3e-08 UniRef50_Q5D5H6 Isocitrate dehydrogenase, NAD-dependent (Fragmen... 58 7e-07 UniRef50_B5E4Z3 3-isopropylmalate dehydrogenase, point mutation ... 54 5e-06 UniRef50_A5B8K4 Putative uncharacterized protein n=2 Tax=Magnoli... 54 8e-06 UniRef50_C6HDM5 Predicted protein n=1 Tax=Ajellomyces capsulatus... 54 9e-06 UniRef50_P56471 Isocitrate dehydrogenase [NAD] subunit alpha, mi... 52 4e-05 UniRef50_Q566P0 Zgc:113076 protein n=6 Tax=Deuterostomia RepID=Q... 49 2e-04 UniRef50_Q11SB4 Putative uncharacterized protein ttuC n=1 Tax=Cy... 49 2e-04 UniRef50_A5LXH0 Putative uncharacterized protein n=1 Tax=Strepto... 48 4e-04 UniRef50_Q4V533 IP13250p (Fragment) n=8 Tax=melanogaster subgrou... 48 6e-04 UniRef50_B5KE47 4-hydroxythreonine-4-phosphate dehydrogenase n=1... 48 8e-04 UniRef50_D1Z545 Whole genome shotgun sequence assembly, scaffold... 46 0.002 UniRef50_B8ARP0 Putative uncharacterized protein n=1 Tax=Oryza s... 46 0.002 UniRef50_Q6UB50 Putative dehydrogenase (Fragment) n=1 Tax=Hyalop... 46 0.002 UniRef50_Q1M832 Putative uncharacterized protein n=1 Tax=Rhizobi... 45 0.004 UniRef50_P56472 Isocitrate dehydrogenase [NAD] subunit beta, mit... 44 0.007 UniRef50_Q2VF40 Isocitrate dehydrogenase 3 gamma subunit (Fragme... 44 0.009 UniRef50_Q9SF26 Putative dehydrogenase n=1 Tax=Arabidopsis thali... 44 0.010 UniRef50_Q0ZQ47 FrbB n=1 Tax=Streptomyces rubellomurinus RepID=Q... 43 0.013 UniRef50_A7IS87 LeuB (Fragment) n=1 Tax=Neisseria meningitidis R... 43 0.024 UniRef50_C0BPH4 3-isopropylmalate dehydrogenase n=1 Tax=Flavobac... 42 0.028 UniRef50_B7BAU1 Putative uncharacterized protein (Fragment) n=1 ... 41 0.063 >UniRef50_Q4QLS3 3-isopropylmalate dehydrogenase n=43 Tax=Bacteria RepID=LEU3_HAEI8 Length = 358 Score = 484 bits (1246), Expect = e-135, Method: Composition-based stats. Identities = 254/357 (71%), Positives = 299/357 (83%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATV 62 ++Y++AVL GDGIGPEVM +A+KVL+ V+ +F ++ + + VGGAAID+ G PLP T+ Sbjct: 2 QSYNVAVLAGDGIGPEVMAEAMKVLNKVQEKFGFKLNFNEFFVGGAAIDHCGYPLPAETL 61 Query: 63 EGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 +GC++ADA+LFGSVGGPKW +LPPDQQPERGALLPLRKHFKLF NLRPA LY+GLE FCP Sbjct: 62 KGCDEADAILFGSVGGPKWTNLPPDQQPERGALLPLRKHFKLFCNLRPATLYKGLEKFCP 121 Query: 123 LRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFES 182 LRADIAA GFD++ VRELTGGIYFGQPKGREG G KAFDTEVY+++EIERIAR AFE+ Sbjct: 122 LRADIAAKGFDMVVVRELTGGIYFGQPKGREGEGSQTKAFDTEVYYKYEIERIARAAFEA 181 Query: 183 ARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDV 242 A KR KVTS+DKANVLQSSILWRE V E+A +YP+V L H+YIDNATMQLIK P FDV Sbjct: 182 AMKRNKKVTSVDKANVLQSSILWRETVTEMAKDYPEVTLEHIYIDNATMQLIKAPESFDV 241 Query: 243 LLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQI 302 LLCSN+FGDI+SDE AMITGSMGMLPSASLNE GFGLYEPAGGSAPDIAGK IANPIAQI Sbjct: 242 LLCSNIFGDIISDEAAMITGSMGMLPSASLNEAGFGLYEPAGGSAPDIAGKGIANPIAQI 301 Query: 303 LSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYV 359 LS A++LRYS + ++AA AIE A+ + L G RT DLA + VST EMG +I + + Sbjct: 302 LSAAMMLRYSFNLNEAADAIESAVQKVLASGHRTADLADDSTPVSTAEMGTLITQAI 358 >UniRef50_Q47WG3 3-isopropylmalate dehydrogenase n=20 Tax=Bacteria RepID=LEU3_COLP3 Length = 362 Score = 460 bits (1183), Expect = e-128, Method: Composition-based stats. Identities = 223/359 (62%), Positives = 277/359 (77%), Gaps = 3/359 (0%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 +IA+L GDGIGPEVM +A KVL+ V ++F ITT YD+GGAAIDNHG LP +T+ GC Sbjct: 3 NIAILAGDGIGPEVMVEAKKVLNTVASKFDFEITTQDYDIGGAAIDNHGNALPDSTMAGC 62 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 ++DA+LFGSVGGPKW +LPP +QPER ALL LR HF LF N+RPA L L + LR+ Sbjct: 63 IESDAILFGSVGGPKWANLPPTEQPERCALLGLRSHFDLFCNMRPATLQPALSSLSTLRS 122 Query: 126 DIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARK 185 DI+ GFD+L +RELTG IYFG+PKGR G G+ E FD+ Y R E++RI+ +AF++A+K Sbjct: 123 DISEQGFDVLVIRELTGDIYFGEPKGRRGEGEEETGFDSMFYSRREVKRISHLAFQAAQK 182 Query: 186 RRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLLC 245 R +KVTS+DKANVL +S LWR++V E+A EYPDVEL H+Y+DNA MQL++DP+QFDV+LC Sbjct: 183 RNNKVTSVDKANVLATSQLWRQVVEEVAVEYPDVELEHLYVDNAAMQLVRDPNQFDVMLC 242 Query: 246 SNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSL 305 NLFGDILSD CAMITGSMG+LPSASLN GFG+YEPAGGSAPDIAG +ANPIAQILS Sbjct: 243 PNLFGDILSDICAMITGSMGLLPSASLNSDGFGMYEPAGGSAPDIAGLGVANPIAQILSA 302 Query: 306 ALLLRYSLDADDAACAIERAINRALEEGIRTGDLARG---AAAVSTDEMGDIIARYVAE 361 AL+LRYSL+ AA AIE A++ AL+ G+ T DL A ST E+GD I + + Sbjct: 303 ALMLRYSLNQGAAAKAIEDAVSNALDNGVLTADLLPANERKNAKSTSEVGDYICKQIES 361 >UniRef50_Q9WZ26 3-isopropylmalate dehydrogenase n=47 Tax=Bacteria RepID=LEU3_THEMA Length = 354 Score = 452 bits (1164), Expect = e-126, Method: Composition-based stats. Identities = 202/357 (56%), Positives = 259/357 (72%), Gaps = 7/357 (1%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 IAVLPGDGIGPEV+ +ALKVL+ V + +GG AID G+PLP T + C Sbjct: 2 KIAVLPGDGIGPEVVREALKVLEVVEKKTGKTFEKVFGHIGGDAIDRFGEPLPEETKKIC 61 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 +ADA+ GSVGGPKW+ LPP+++PE G LL LRK L++N+RP K+Y+ L PL+ Sbjct: 62 LEADAIFLGSVGGPKWDDLPPEKRPEIGGLLALRKMLNLYANIRPIKVYRSLVHVSPLKE 121 Query: 126 DIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARK 185 + +G D++ VREL+ G+Y+GQP+G + EK FDT +Y R +ERIAR AFE A+ Sbjct: 122 KVIGSGVDLVTVRELSYGVYYGQPRGLD----EEKGFDTMIYDRKTVERIARTAFEIAKN 177 Query: 186 RRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLLC 245 RR KVTS+DKANVL SS+LWR++VNE+A EYPDVEL H+Y+DNA MQLI PSQFDV+L Sbjct: 178 RRKKVTSVDKANVLYSSMLWRKVVNEVAREYPDVELTHIYVDNAAMQLILKPSQFDVILT 237 Query: 246 SNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSL 305 +N+FGDILSDE A + GS+G+LPSAS ++ LYEPAGGSAPDIAGKNIANPIAQILSL Sbjct: 238 TNMFGDILSDESAALPGSLGLLPSASFGDKN--LYEPAGGSAPDIAGKNIANPIAQILSL 295 Query: 306 ALLLRYSLDADDAACAIERAINRALEEGIRTGDLARG-AAAVSTDEMGDIIARYVAE 361 A++L +S + A IERA+ +EEG RT D+A AVST +MGD+I + + E Sbjct: 296 AMMLEHSFGMVEEARKIERAVELVIEEGYRTRDIAEDPEKAVSTSQMGDLICKKLEE 352 >UniRef50_Q493R1 3-isopropylmalate dehydrogenase n=224 Tax=Bacteria RepID=LEU3_BLOPB Length = 366 Score = 448 bits (1152), Expect = e-124, Method: Composition-based stats. Identities = 227/361 (62%), Positives = 284/361 (78%), Gaps = 1/361 (0%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPA 60 M+ NYHIAVLPGDGIGPE Q K+L+ ++ +F + I T+ + +GG AI++ G P P + Sbjct: 1 MNNNYHIAVLPGDGIGPETTRQVYKILNVIKKQFQINIVTTEHKIGGDAINSEGTPFPKS 60 Query: 61 TVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAF 120 T++ CEQ++A+LFG+VGGP+W HL + PE+GALL LRKHF LF+NLRP L L+ Sbjct: 61 TLKYCEQSNAILFGAVGGPQWTHLKGSESPEQGALLALRKHFNLFANLRPIYLADELKEL 120 Query: 121 CPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAF 180 PL ++ NG DI+ VRELTGGIYFGQPKGR G+G E AFDT VYHRFEIERIA IAF Sbjct: 121 SPLNINMIPNGIDIIFVRELTGGIYFGQPKGRSGTGLNEYAFDTAVYHRFEIERIANIAF 180 Query: 181 ESARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQF 240 + A+KRR +V+SIDKANVL +S+LWRE+V+ +A YPDVEL H+YIDNA+MQLI +PS+F Sbjct: 181 KLAQKRRKRVSSIDKANVLHTSMLWREVVSHLAKNYPDVELEHLYIDNASMQLINNPSKF 240 Query: 241 DVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIA 300 D++LC NLFGDILSDECAMI+GS+GMLPSAS+NE FGLYEPAGGSAPDIA KNIANPIA Sbjct: 241 DIILCPNLFGDILSDECAMISGSIGMLPSASINEHNFGLYEPAGGSAPDIAEKNIANPIA 300 Query: 301 QILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARG-AAAVSTDEMGDIIARYV 359 ILS+ALL RYSL D A IE+A+++AL G RT D+A+ ++ST+EMGDIIA + Sbjct: 301 HILSIALLFRYSLKLDHIAIKIEKAVSQALMLGYRTIDIAKKHEKSISTNEMGDIIAALI 360 Query: 360 A 360 Sbjct: 361 K 361 >UniRef50_D1HRU7 3-isopropylmalate dehydrogenase (Fragment) n=2 Tax=Vitis vinifera RepID=D1HRU7_VITVI Length = 506 Score = 434 bits (1116), Expect = e-120, Method: Composition-based stats. Identities = 184/364 (50%), Positives = 247/364 (67%), Gaps = 4/364 (1%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPAT 61 K Y I +LPGDGIGPEV++ A VL + + VGG A+D G PLP T Sbjct: 141 PKRYSITLLPGDGIGPEVISVAKNVLKLAGSLEGIEFGFQEMPVGGCALDLTGVPLPEET 200 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 + +Q+DAVL G++GG KW+ +PE G LL LR K+F+NLRPA + L Sbjct: 201 LLVAKQSDAVLLGAIGGYKWDSNEKHLKPETG-LLQLRSGLKVFANLRPASVLPQLVDAS 259 Query: 122 PLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQ-YEKAFDTEVYHRFEIERIARIAF 180 L+ ++ A G D++ VRELTGGIYFG+P+G + E F+TEVY +EI+RIARIAF Sbjct: 260 TLKKEV-AEGVDLMVVRELTGGIYFGKPRGFSKNENGEEIGFNTEVYATYEIDRIARIAF 318 Query: 181 ESARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQF 240 E+A+KRR K+ S+DKANVL++S+LWR+ V +A+EYPDVEL+HMY+DNA MQL+++P QF Sbjct: 319 ETAQKRRGKLCSVDKANVLEASMLWRKRVTAMASEYPDVELSHMYVDNAAMQLVRNPKQF 378 Query: 241 DVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIA 300 D ++ +N+FGDILSDE +MITGS+GMLPSAS+ E G GL+EP GSAPDIAG++ ANP+A Sbjct: 379 DTIVTNNIFGDILSDEASMITGSIGMLPSASVGESGPGLFEPIHGSAPDIAGQDKANPLA 438 Query: 301 QILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAA-VSTDEMGDIIARYV 359 +LS A+LLRY L +AA IE A+ L+ G RT D+ V EMG+ + + V Sbjct: 439 TVLSAAMLLRYGLGEGNAAKRIETAVLDTLDRGFRTRDIYEAGTKLVGCKEMGEQVLKAV 498 Query: 360 AEGV 363 + Sbjct: 499 ESQI 502 >UniRef50_Q9FMT1 3-isopropylmalate dehydrogenase 3, chloroplastic n=385 Tax=cellular organisms RepID=LEU33_ARATH Length = 409 Score = 415 bits (1068), Expect = e-115, Method: Composition-based stats. Identities = 188/364 (51%), Positives = 246/364 (67%), Gaps = 4/364 (1%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPAT 61 K Y+IA+LPGDGIGPEV++ A VL + + VGGAA+D G PLP T Sbjct: 44 KKRYNIALLPGDGIGPEVISVAKNVLQKAGSLEGLEFDFKEMPVGGAALDLVGVPLPEET 103 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 + +DA+L G++GG KW+ +PE AL LR+ K+F+NLRPA + L Sbjct: 104 FTAAKLSDAILLGAIGGYKWDKNEKHLRPEM-ALFYLRRDLKVFANLRPATVLPQLVDAS 162 Query: 122 PLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQ-YEKAFDTEVYHRFEIERIARIAF 180 L+ ++ A G D++ VRELTGGIYFG+P+G + E TE+Y EI+RIAR+AF Sbjct: 163 TLKKEV-AEGVDMMIVRELTGGIYFGEPRGITINENGEEVGVSTEIYAAHEIDRIARVAF 221 Query: 181 ESARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQF 240 E+ARKRR K+ S+DKANVL +SILWR+ V +A+EYPDVEL+HMY+DNA MQLI+DP QF Sbjct: 222 ETARKRRGKLCSVDKANVLDASILWRKRVTALASEYPDVELSHMYVDNAAMQLIRDPKQF 281 Query: 241 DVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIA 300 D ++ +N+FGDILSDE +MITGS+GMLPSASL E G GL+EP GSAPDIAG++ ANP+A Sbjct: 282 DTIVTNNIFGDILSDEASMITGSIGMLPSASLGESGPGLFEPIHGSAPDIAGQDKANPLA 341 Query: 301 QILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAA-VSTDEMGDIIARYV 359 ILS A+LL+Y L + AA IE A+ AL +G RTGD+ V EMG+ + + V Sbjct: 342 TILSAAMLLKYGLGEEKAAKRIEDAVVDALNKGFRTGDIYSPGNKLVGCKEMGEEVLKSV 401 Query: 360 AEGV 363 V Sbjct: 402 ESKV 405 >UniRef50_C9KJM9 3-isopropylmalate dehydrogenase n=1 Tax=Mitsuokella multacida DSM 20544 RepID=C9KJM9_9FIRM Length = 355 Score = 413 bits (1061), Expect = e-114, Method: Composition-based stats. Identities = 177/357 (49%), Positives = 245/357 (68%), Gaps = 4/357 (1%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 +Y I V+PGDGIG E+ A++VL+ V +F + ++ ++ D GG A D G PLP T+E Sbjct: 2 SYKITVIPGDGIGKEITDSAVEVLEKVDEKFGLGLSYTYKDAGGTAYDKFGTPLPDDTIE 61 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 C+ +D VLFG+VGG KW+++ P +PE+ A+L LRK+ L++NLRP K+ L + PL Sbjct: 62 ACKASDGVLFGAVGGDKWDNVDPALRPEK-AILGLRKNLGLYANLRPVKVADALVEYSPL 120 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 + ++ G D++ VREL GGIYFG E E+A+D E Y E++RIA++AFE+A Sbjct: 121 KPELV-KGVDLVIVRELIGGIYFGDKCESEQHNGAERAWDLENYSVPEVDRIAKLAFETA 179 Query: 184 RKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVL 243 + RR KVTS+DKANVL +S LWR V ++A YPDVEL ++Y+DN MQL P+QFDV+ Sbjct: 180 KLRRGKVTSVDKANVLATSRLWRRTVAKVAESYPDVELNNLYVDNCAMQLAIRPTQFDVI 239 Query: 244 LCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQIL 303 + NLFGDILSDE A++ GS+GM+PSAS+ LYEP GSAPDIAGK IANP+ IL Sbjct: 240 VTGNLFGDILSDEAAVVGGSIGMMPSASIG-TSTSLYEPIHGSAPDIAGKGIANPMGTIL 298 Query: 304 SLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGA-AAVSTDEMGDIIARYV 359 S A+LLRYSL + AA AIE A+++AL +G RT DL + +T+E+ +I + Sbjct: 299 SAAMLLRYSLHEEAAAKAIEAAVDKALADGYRTPDLWKEGFQKANTEEITKVICERI 355 >UniRef50_Q6GF15 3-isopropylmalate dehydrogenase n=94 Tax=Bacilli RepID=LEU3_STAAR Length = 348 Score = 408 bits (1048), Expect = e-112, Method: Composition-based stats. Identities = 166/356 (46%), Positives = 237/356 (66%), Gaps = 11/356 (3%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 Y+I LPGDGIGPE++ +L +L+ + N++ H++ GGA+ID G+PL T+ Sbjct: 2 TYNIVALPGDGIGPEILNGSLSLLEIISNKYNFNYQIEHHEFGGASIDTFGEPLTEKTLN 61 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 C++ADA+L G++GGPKW P+ +PE+G LL LRK LF+N+RP + +G + PL Sbjct: 62 ACKRADAILLGAIGGPKWTD--PNNRPEQG-LLKLRKSLNLFANIRPTTVVKGASSLSPL 118 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 +A+ G D++ VRELT GIYFG+P+ +A D+ Y R EIERI +AF+ A Sbjct: 119 KAE-RVEGTDLVIVRELTSGIYFGEPRYF----NNHEALDSLTYTREEIERIVHVAFKLA 173 Query: 184 RKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVL 243 RR K+TS+DK NVL SS LWR++VNE++ YP+V + H+ +D +M LI +P QFDV+ Sbjct: 174 ASRRGKLTSVDKENVLASSKLWRKVVNEVSQLYPEVTVNHLLVDACSMHLITNPKQFDVI 233 Query: 244 LCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQIL 303 + NLFGDILSDE ++I GS+G+ PSAS + G LYEP GSAPDIAGKN+ANP IL Sbjct: 234 VYENLFGDILSDEASVIPGSLGLSPSASFSNDGPRLYEPIHGSAPDIAGKNVANPFGMIL 293 Query: 304 SLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYV 359 SLA+ LR SL+ DAA +E+ I +E G T DL ++T ++ +I+++ + Sbjct: 294 SLAMCLRESLNQPDAADELEQHIYNMIEHGQTTADL---GGKLNTTDIFEILSQKL 346 >UniRef50_Q5SIY4 3-isopropylmalate dehydrogenase n=53 Tax=cellular organisms RepID=LEU3_THET8 Length = 345 Score = 398 bits (1022), Expect = e-109, Method: Composition-based stats. Identities = 176/355 (49%), Positives = 237/355 (66%), Gaps = 11/355 (3%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 +AVLPGDGIGPEV ALKVL A+ + + + GGAAID G+P P T +G Sbjct: 2 KVAVLPGDGIGPEVTEAALKVLRALDEAEGLGLAYEVFPFGGAAIDAFGEPFPEPTRKGV 61 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 E+A+AVL GSVGGPKW+ LP +PE G LL LRK LF+NLRPAK++ GLE PL+ Sbjct: 62 EEAEAVLLGSVGGPKWDGLPRKIRPETG-LLSLRKSQDLFANLRPAKVFPGLERLSPLKE 120 Query: 126 DIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARK 185 +I A G D+L VRELTGGIYFG+P+G + +A++TE Y + E+ER+AR+AFE+ARK Sbjct: 121 EI-ARGVDVLIVRELTGGIYFGEPRGMSEA----EAWNTERYSKPEVERVARVAFEAARK 175 Query: 186 RRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLLC 245 RR V S+DKANVL+ WR+ V E+ YPDV L H Y+D M L++ P++FDV++ Sbjct: 176 RRKHVVSVDKANVLEVGEFWRKTVEEVGRGYPDVALEHQYVDAMAMHLVRSPARFDVVVT 235 Query: 246 SNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSL 305 N+FGDILSD +++ GS+G+LPSASL +G ++EP GSAPDIAGK IANP A ILS Sbjct: 236 GNIFGDILSDLASVLPGSLGLLPSASLG-RGTPVFEPVHGSAPDIAGKGIANPTAAILSA 294 Query: 306 ALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYVA 360 A++L ++ + A +E A+ +AL E DL + T+ + R++A Sbjct: 295 AMMLEHAFGLVELARKVEDAVAKALLETPP-PDL---GGSAGTEAFTATVLRHLA 345 >UniRef50_Q5HMF8 3-isopropylmalate dehydrogenase n=9 Tax=Bacilli RepID=LEU3_STAEQ Length = 347 Score = 396 bits (1019), Expect = e-109, Method: Composition-based stats. Identities = 161/352 (45%), Positives = 224/352 (63%), Gaps = 11/352 (3%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 +Y I LPGDGIGPE+++ L++L + ++ + GG +ID +G PL T++ Sbjct: 2 SYKIVALPGDGIGPEILSGTLELLKLISEKYHFEYHLESHHFGGVSIDYYGTPLTNETLQ 61 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 C+ ADA+L G++GGPKW P+ +PE G LL LRK LF+N+RP + +G PL Sbjct: 62 SCKNADAILLGAIGGPKWTD--PNNRPEHG-LLKLRKSLNLFANIRPTFVTKGASHLSPL 118 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 + DI G D++ VRELT GIYFG+P + + +A D+ Y EIERI RIAF A Sbjct: 119 KQDIV-EGTDLVIVRELTSGIYFGEPSYVKKT----EALDSLKYSSQEIERIVRIAFNLA 173 Query: 184 RKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVL 243 +RR K+TS+DK NVL SS LWR+IVN++ +YP+VE+ HM +D +M LI P+QFDV+ Sbjct: 174 NRRRKKLTSVDKENVLSSSKLWRQIVNDVKKDYPEVEVNHMLVDACSMHLITQPTQFDVI 233 Query: 244 LCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQIL 303 + NLFGDILSDE ++I GS+G+ PSAS + G LYEP GSAPDIA ++ ANP +L Sbjct: 234 VTENLFGDILSDEASVIPGSLGLSPSASFGQTGTRLYEPIHGSAPDIANEDKANPFGMVL 293 Query: 304 SLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDII 355 SLAL LR SL+ +DAA +E + ++ T DL T E+ ++ Sbjct: 294 SLALCLRESLNQNDAANELESIVYSFIQSNKTTADL---GGQYRTSEIFKLL 342 >UniRef50_Q81G11 3-isopropylmalate dehydrogenase n=105 Tax=Bacteria RepID=LEU3_BACCR Length = 354 Score = 392 bits (1008), Expect = e-108, Method: Composition-based stats. Identities = 168/356 (47%), Positives = 218/356 (61%), Gaps = 13/356 (3%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 I L GDG+GPEVM A +VL V + GG AID GQPLP T+ C Sbjct: 4 RIVCLAGDGVGPEVMESAKEVLHMVERLYGHHFHLQDEYFGGVAIDLTGQPLPQRTLAAC 63 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 +DAVL G+VGGP+W+ ++PE+G LL LRK +F+N+RP + PL+ Sbjct: 64 LASDAVLLGAVGGPRWDS--AKERPEKG-LLALRKGLGVFANVRPVTVESATAHLSPLKN 120 Query: 126 DIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARK 185 A+ D + VRELTGGIYF PK R E A DT YHR EIERI AF+ A K Sbjct: 121 ---ADEIDFVVVRELTGGIYFSYPKERT----EEVATDTLTYHRHEIERIVSYAFQLANK 173 Query: 186 RRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLLC 245 R+ KVTSIDKANVL+SS LWR + E+A YP+VE+ H+ +D A M+LI++P +FDV++ Sbjct: 174 RKKKVTSIDKANVLESSKLWRTVTEEVALRYPNVEVEHILVDAAAMELIRNPGRFDVIVT 233 Query: 246 SNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSL 305 NLFGDILSDE +++ GS+GMLPSAS E+G LYEP GSAPDIAGKN ANPIA + S+ Sbjct: 234 ENLFGDILSDEASVLAGSLGMLPSASHAEKGPSLYEPIHGSAPDIAGKNKANPIAMMRSV 293 Query: 306 ALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYVAE 361 A++L S AIE A++ L+ G T D+ +T + + + E Sbjct: 294 AMMLGQSFGLTREGYAIEEAVSAVLKSGKCTADI---GGTETTTSFTKAVIQEMEE 346 >UniRef50_D0J9Z6 3-isopropylmalate dehydrogenase n=7 Tax=Bacteroidetes RepID=D0J9Z6_BLASP Length = 353 Score = 388 bits (997), Expect = e-106, Method: Composition-based stats. Identities = 157/361 (43%), Positives = 233/361 (64%), Gaps = 11/361 (3%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPA 60 M KN I V+ GDGIGPEV+ QA+K L+++ NRF + + G AI+ G P+P Sbjct: 1 MKKN--IVVIEGDGIGPEVIKQAIKALNSIGNRFHHEFSYQNVLAGAKAIETFGDPMPKE 58 Query: 61 TVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAF 120 T++ C ++DAVLFGS+G PK++ P +PE G LL LRK L+ N+RP Y G+ Sbjct: 59 TIDSCLKSDAVLFGSIGDPKYDSYPRGMRPEDG-LLKLRKEMDLYCNIRPIVTYPGINK- 116 Query: 121 CPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAF 180 P++ + G + + RELTGGIYFG+ S ++A+D VY EIERI ++F Sbjct: 117 SPIK-ERKLEGVNFVIYRELTGGIYFGKKG---RSKNGKEAYDYCVYSEKEIERIGEMSF 172 Query: 181 ESARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQF 240 ++AR R K+T +DKANVL++S LWRE++ ++A +Y DV+L +YIDNA MQ++ +P +F Sbjct: 173 KAARSRNRKMTLVDKANVLETSRLWREVIQKMALDYSDVDLEFLYIDNAAMQILINPRKF 232 Query: 241 DVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIA 300 DV+L N+FGDILSDE +++T S+G+LPSAS+ + L+EP GS P GKNIANP+ Sbjct: 233 DVILTDNMFGDILSDEASILTSSLGLLPSASIGSKK-SLFEPIHGSYPQAKGKNIANPLG 291 Query: 301 QILSLALLLRYSLDADDAACAIERAINRALEEGIRTGD-LARGAAAVSTDEMGDIIARYV 359 ILS++++L Y + +E A+ +++E I T D + + ST+E+GD I +Y+ Sbjct: 292 CILSVSMMLEY-FEMPQEKNLLEEAVKSSIQEKICTPDIILDDRNSSSTEEVGDYIEKYI 350 Query: 360 A 360 Sbjct: 351 K 351 >UniRef50_Q2YL58 3-isopropylmalate dehydrogenase n=285 Tax=cellular organisms RepID=LEU3_BRUA2 Length = 370 Score = 387 bits (994), Expect = e-106, Method: Composition-based stats. Identities = 179/366 (48%), Positives = 231/366 (63%), Gaps = 11/366 (3%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 + + +LPGDGIGPE M + KV+ + + + T VGG A D HGQ + A +E Sbjct: 3 SRKLLLLPGDGIGPEAMAEVRKVIAFLNSDLNLGFETEEGLVGGCAYDAHGQAISDADME 62 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 AD+VLFG+VGGPKW+ +P + +PE G LL LRK +L++NLRPA Y L L Sbjct: 63 KALAADSVLFGAVGGPKWDSVPYEVRPEAG-LLRLRKDMQLYANLRPAICYPALAHSSSL 121 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQ-YEKAFDTEVYHRFEIERIARIAFES 182 + ++ G DIL +RELTGG+YFG+PK G ++ DT+VY +EIERIA +AFE Sbjct: 122 KPEVI-EGLDILILRELTGGVYFGEPKEIIDLGNGQKRGIDTQVYDTYEIERIADVAFEL 180 Query: 183 ARKRRHKVTSIDKANVLQSSILWREIVNEIATE-YPDVELAHMYIDNATMQLIKDPSQFD 241 AR RR+KVTS++K NV++S +LW + V E + DV+L HM D MQL++ P QFD Sbjct: 181 ARTRRNKVTSMEKRNVMKSGVLWNQGVTARHKEKHADVQLEHMLADAGGMQLVRWPKQFD 240 Query: 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNE------QGFGLYEPAGGSAPDIAGKNI 295 V+L NLFGD+LSD AM+TGS+GMLPSASL + LYEP GSAPDIAGK I Sbjct: 241 VILTDNLFGDLLSDVAAMLTGSLGMLPSASLGAADSKTGKRKALYEPVHGSAPDIAGKGI 300 Query: 296 ANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDL-ARGAAAVSTDEMGDI 354 ANPIA I SLA+ LRYS A +E AI L++GIRT D+ + G V T EMGD Sbjct: 301 ANPIAMIASLAMCLRYSFGLVAEADRLEAAIAGVLDDGIRTADIWSEGNTKVGTTEMGDA 360 Query: 355 IARYVA 360 I Sbjct: 361 ILAKFK 366 >UniRef50_Q4FP17 3-isopropylmalate dehydrogenase n=11 Tax=cellular organisms RepID=LEU3_PELUB Length = 368 Score = 386 bits (991), Expect = e-106, Method: Composition-based stats. Identities = 171/366 (46%), Positives = 236/366 (64%), Gaps = 10/366 (2%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATV 62 K I +LPGDGIGPEV+ + KV+ + + ++ GG + D HG P+ Sbjct: 5 KKRKILLLPGDGIGPEVIQEVKKVILWLNSNKSLDFEIDEDLAGGCSYDKHGTPITDEVF 64 Query: 63 EGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 +++ V+ G+VGGPKW++L ++PER L K KLF+NLRPA ++ L Sbjct: 65 YKALESEFVMLGAVGGPKWDNLEFSKKPERALLKLR-KELKLFANLRPAICFEQLVDAST 123 Query: 123 LRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYE-KAFDTEVYHRFEIERIARIAFE 181 L+ +I + G DI+ VRELTGGIYFG+P+G + E K +T Y EI R+A++AF+ Sbjct: 124 LKPEIVS-GLDIMIVRELTGGIYFGEPRGIKPIENGERKGINTHSYTTSEIVRVAKVAFD 182 Query: 182 SARKRRHKVTSIDKANVLQSSILWREIVNEIA-TEYPDVELAHMYIDNATMQLIKDPSQF 240 ARKR ++VTS +K+NV+++ LW+E V E+ EY DVEL+HM DN MQL+K+P QF Sbjct: 183 LARKRSNRVTSCEKSNVMEAGQLWKEEVQELHDKEYKDVELSHMLADNCAMQLLKNPKQF 242 Query: 241 DVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGF-----GLYEPAGGSAPDIAGKNI 295 DV++ NLFGD+LSD+ +M+TGS+G+LPSASL + +YEP GSAPDIAGK I Sbjct: 243 DVIVTDNLFGDMLSDQASMLTGSLGLLPSASLGAKNKDGEMRAMYEPIHGSAPDIAGKEI 302 Query: 296 ANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGD-LARGAAAVSTDEMGDI 354 ANPIA ILS A+ LRYSLD D A A+E+A+ L +G+RT D L++G VST MGD Sbjct: 303 ANPIASILSFAMALRYSLDLDSEADALEKAVQDVLNDGLRTKDILSQGKKEVSTSAMGDA 362 Query: 355 IARYVA 360 I + Sbjct: 363 IISKLQ 368 >UniRef50_Q2J3B4 3-isopropylmalate dehydrogenase n=132 Tax=Bacteria RepID=LEU3_RHOP2 Length = 370 Score = 386 bits (991), Expect = e-106, Method: Composition-based stats. Identities = 171/366 (46%), Positives = 237/366 (64%), Gaps = 11/366 (3%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 + + +LPGDGIG EVM + +++D + T H VGGAA D + AT+ Sbjct: 3 THKLLLLPGDGIGTEVMAEVSRLIDWLNKAGIASFETEHGLVGGAAYDADKVAITDATMA 62 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 + +DAV+FG+VGGPKW+ +P D +PE G LL LRK LF+NLRPA Y L L Sbjct: 63 LAQASDAVIFGAVGGPKWDAVPYDARPEAG-LLRLRKDLALFANLRPAVCYPALAEASSL 121 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQ-YEKAFDTEVYHRFEIERIARIAFES 182 + ++ G DI+ VRELTGG+YFG+PK G ++A DT+VY +EIERI R+AF+ Sbjct: 122 KPEVV-EGLDIMIVRELTGGVYFGEPKTITDLGNGQKRAIDTQVYDTYEIERIGRVAFDL 180 Query: 183 ARKRRHKVTSIDKANVLQSSILWREIVNEI-ATEYPDVELAHMYIDNATMQLIKDPSQFD 241 ARKRR+KVTS++K NV+++ +LW E++ ++ A EY DV+L H D+ M L+K P QFD Sbjct: 181 ARKRRNKVTSMEKRNVMKTGVLWNEVITQVHAREYKDVQLEHQLADSGGMNLVKWPKQFD 240 Query: 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNE------QGFGLYEPAGGSAPDIAGKNI 295 V++ NLFGD+LSD AM+TGS+GMLPSASL + +YEP GSAPDIAGK + Sbjct: 241 VIVTDNLFGDMLSDIAAMLTGSLGMLPSASLGAVDDTTGKRKAMYEPVHGSAPDIAGKGL 300 Query: 296 ANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDL-ARGAAAVSTDEMGDI 354 ANP+A + S + LRYSLD + A ++ AI L G+RT D+ + G+ VST +MG+ Sbjct: 301 ANPVAMLASFGMALRYSLDMGELADKLDEAIAVVLARGLRTADIKSEGSTVVSTSQMGEA 360 Query: 355 IARYVA 360 I + + Sbjct: 361 IVQEMQ 366 >UniRef50_B1I496 3-isopropylmalate dehydrogenase n=4 Tax=Bacteria RepID=B1I496_DESAP Length = 364 Score = 385 bits (990), Expect = e-105, Method: Composition-based stats. Identities = 137/362 (37%), Positives = 195/362 (53%), Gaps = 13/362 (3%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPA 60 M K Y IAV+PGDG GPE + + LKVL A + + T+ D GG G+ LPP Sbjct: 13 MQKTYKIAVIPGDGTGPEQVREGLKVLHAAAGKEGFALETTVLDWGGEYYLRTGEVLPPD 72 Query: 61 TVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAF 120 VE ++ DA+ G++G P+ E+G LL LR + NLRP KLY G+E Sbjct: 73 AVEQLKRYDAIYLGAIGHPEVR----PGILEKGILLRLRFELDQYINLRPVKLYPGVETP 128 Query: 121 CPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAF 180 A D + VRE T G+Y G + E A T + R +ER R AF Sbjct: 129 I---AGKGPEDIDFVVVRENTEGLYAGSGGFLKRGTPDEVAIQTSINTRKGVERCVRFAF 185 Query: 181 ESARKR--RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDP 237 E RKR R KVT K NVL + LW + NE+ EYPD+E + ++D M ++K+P Sbjct: 186 EYCRKRGGRRKVTLCGKTNVLTFAFDLWERVFNEVGEEYPDIERDYAHVDAICMWMVKNP 245 Query: 238 SQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIAN 297 FDV++ N+FGDI++D AM+ G MG+ +LN +G ++EP GGSAP GKN+ N Sbjct: 246 EWFDVIVTDNMFGDIITDLGAMLQGGMGIAAGGNLNPEGVSMFEPIGGSAPKYTGKNVIN 305 Query: 298 PIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIAR 357 P+A + + A++L L AA IE A+ + +++ LA G TDE+GD++ Sbjct: 306 PLAAVCAGAMMLE-QLGETGAAARIEEAVKKVCAGHLKS--LAAGRMGYGTDEVGDLVVS 362 Query: 358 YV 359 ++ Sbjct: 363 HL 364 >UniRef50_O29627 3-isopropylmalate dehydrogenase n=91 Tax=cellular organisms RepID=LEU3_ARCFU Length = 326 Score = 381 bits (980), Expect = e-104, Method: Composition-based stats. Identities = 132/356 (37%), Positives = 203/356 (57%), Gaps = 35/356 (9%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 I V+PGDGIG EVM A+ +L+ + + S+YD G A++ +G+ LP T+E C Sbjct: 3 KIVVIPGDGIGKEVMEAAMLILE----KLDLPFEYSYYDAGDEALEKYGKALPDETLEAC 58 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 ++DAVLFG+ G + ++ LR+ F+N+RPAK +G+E P Sbjct: 59 RKSDAVLFGAAG-----------ETAADVIVRLRRELGTFANVRPAKAIEGIECLYP--- 104 Query: 126 DIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA-R 184 G DI+ VRE T +Y G G + V R ERIAR AFE A R Sbjct: 105 -----GLDIVVVRENTECLYMGFEFGFGDVTEA-----IRVITREASERIARYAFELAKR 154 Query: 185 KRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVL 243 + R KVT++ KANV++ + L+R++ E+A +YP+++ YID A M L+ DP +FDV+ Sbjct: 155 EGRKKVTALHKANVMKKTCGLFRDVCREVAKDYPEIQYNDYYIDAACMYLVMDPFRFDVI 214 Query: 244 LCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQIL 303 + +N+FGDI+SD A + G +G+ PSA++ E+ ++EP G+A DIAGK IANP A IL Sbjct: 215 VTTNMFGDIVSDLAAGLVGGLGLAPSANVGER-TAIFEPVHGAAFDIAGKGIANPTAMIL 273 Query: 304 SLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYV 359 + ++LR+ + A +E A+ + ++EG +T DL + T E + +A + Sbjct: 274 TACMMLRH-FGYVEEAKKVEEAVEKTIKEGKKTPDL---GGNLKTMEFANEVASLL 325 >UniRef50_Q5LAB4 3-isopropylmalate dehydrogenase n=58 Tax=Bacteria RepID=LEU3_BACFN Length = 353 Score = 381 bits (979), Expect = e-104, Method: Composition-based stats. Identities = 158/358 (44%), Positives = 225/358 (62%), Gaps = 9/358 (2%) Query: 5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEG 64 + IAVL GDGIGPE+ Q ++V+ AV +F ++ + G AID G P P T Sbjct: 3 FKIAVLAGDGIGPEISVQGVEVMSAVCEKFGHKVNYEYAICGADAIDKVGDPFPEETYRV 62 Query: 65 CEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 C+ ADAVLF +VG PK+++ P + LL +RK LF+N+RP + ++ L PLR Sbjct: 63 CKNADAVLFSAVGDPKFDNDPTAKVRPEQGLLAMRKKLGLFANIRPVQTFKCLVHKSPLR 122 Query: 125 ADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESAR 184 A++ G D LC+RELTGG+YFG+ +KA+DT +Y R EIERI ++ FE A Sbjct: 123 AELV-EGADFLCIRELTGGMYFGEK-----YQDNDKAYDTNMYTRPEIERILKVGFEYAM 176 Query: 185 KRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLL 244 KRR +T +DKANVL SS LWR+I E+A +YP+V +M++DNA M++I++P FDV++ Sbjct: 177 KRRKHLTVVDKANVLASSRLWRQIAQEMAPQYPEVTTDYMFVDNAAMKMIQEPKFFDVMV 236 Query: 245 CSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILS 304 N FGDIL+DE ++I+GSMG+LPSAS E ++EP GS P G NIANP+AQILS Sbjct: 237 TENTFGDILTDEGSVISGSMGLLPSASTGESTP-VFEPIHGSWPQAKGLNIANPLAQILS 295 Query: 305 LALLLRYSLDADDAACAIERAINRALEEGIRTGDL-ARGAAAVSTDEMGDIIARYVAE 361 +A+L Y D I +A++ +L+ +RT ++ G T E+G I Y+ + Sbjct: 296 VAMLFEY-FDCKAEGALIRKAVDASLDANVRTPEIQVEGGEKFGTKEVGAWIVDYIRK 352 >UniRef50_Q46NL2 Tartrate dehydrogenase n=12 Tax=Bacteria RepID=Q46NL2_RALEJ Length = 358 Score = 380 bits (977), Expect = e-104, Method: Composition-based stats. Identities = 135/364 (37%), Positives = 194/364 (53%), Gaps = 17/364 (4%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPAT 61 ++ Y IAV+PGDGIG EV+ + ++VL+A +F ++ + YD A + G +P Sbjct: 4 NQQYKIAVIPGDGIGNEVVPEGIRVLEAASAKFGFKLAFTTYDWSCARYHSQGSMMPSDG 63 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 +E +DA+ G+VG P PD L+P+R+ F + NLRP +L G+ C Sbjct: 64 IERLRDSDAIFLGAVGFPG----VPDHVSLWNLLIPIRREFDQYVNLRPVRLLPGVP--C 117 Query: 122 PLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFE 181 PL A+ D VRE T G Y ++E ++ R +RI R AF+ Sbjct: 118 PL-ANKKPGDIDFWIVRENTEGEYSQVGGRMFAGTEHEFVTQEAIFTRRGTDRIMRYAFD 176 Query: 182 SARK-RRHKVTSIDKAN-VLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQ 239 A+K R+ VTS K+N + S W E + EYPD+ +ID + P + Sbjct: 177 LAKKLGRNHVTSATKSNGIFHSMPFWDERFAAVGAEYPDIRTDQYHIDILAARFAMSPER 236 Query: 240 FDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQG--FGLYEPAGGSAPDIAGKNIAN 297 FDV++ SNLFGDILSD ITG++ + PSA++N + ++EP GSAPDIAG+ IAN Sbjct: 237 FDVVVGSNLFGDILSDLGPGITGTIAVAPSANINPERKYPSMFEPVHGSAPDIAGQGIAN 296 Query: 298 PIAQILSLALLLRYSLDADDAACAIERAINRALE--EGIRTGDLARGAAAVSTDEMGDII 355 PI QI S A++L + L +AA AI +AI L + + T DL ST +MG I Sbjct: 297 PIGQIWSGAMMLEH-LGQPEAAAAIMQAIETVLTHPDRVHTPDL---GGRASTQQMGAEI 352 Query: 356 ARYV 359 AR V Sbjct: 353 ARAV 356 >UniRef50_Q2K2V0 3-isopropylmalate dehydrogenase n=11 Tax=Alphaproteobacteria RepID=LEU3_RHIEC Length = 370 Score = 378 bits (972), Expect = e-103, Method: Composition-based stats. Identities = 175/361 (48%), Positives = 230/361 (63%), Gaps = 11/361 (3%) Query: 9 VLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCEQA 68 +LPGDGIGPE M + K++ + T VGG A D HG + A ++ A Sbjct: 8 LLPGDGIGPEAMGEVRKIIAYMNEAMDAGFVTDEGLVGGCAYDAHGAAISEADMQKALAA 67 Query: 69 DAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRADIA 128 DAVLFG+VGGPKW+ +P + +PE G LL LRK +LF+NLRPA Y L + L+ ++ Sbjct: 68 DAVLFGAVGGPKWDSVPYEVRPEAG-LLRLRKDLQLFANLRPAICYPALASASSLKPELV 126 Query: 129 ANGFDILCVRELTGGIYFGQPKGREGSGQ-YEKAFDTEVYHRFEIERIARIAFESARKRR 187 G DIL +RELTGG+YFG+PK G ++ DT+VY +EIERIA +AFE AR R+ Sbjct: 127 -EGLDILIIRELTGGVYFGEPKEIIDLGNGQKRGIDTQVYDTYEIERIAGVAFEMARTRQ 185 Query: 188 HKVTSIDKANVLQSSILWREIVNEIAT-EYPDVELAHMYIDNATMQLIKDPSQFDVLLCS 246 ++V S++K NV++S +LW ++V E +Y DV+L HM D MQL++ P QFDV++ Sbjct: 186 NRVCSMEKRNVMKSGVLWNQVVTETHKAKYSDVQLEHMLADAGGMQLVRQPKQFDVIVTD 245 Query: 247 NLFGDILSDECAMITGSMGMLPSASLNE------QGFGLYEPAGGSAPDIAGKNIANPIA 300 NLFGD+LSD AM+TGS+GMLPSASL + LYEP GSAPDIAGK IANPIA Sbjct: 246 NLFGDMLSDVAAMLTGSLGMLPSASLGAPDGKTGKRKALYEPVHGSAPDIAGKGIANPIA 305 Query: 301 QILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDL-ARGAAAVSTDEMGDIIARYV 359 I S A+ LRYS + A +E+AI L++GIRTGD+ A G V T EMG+ I Sbjct: 306 MIASFAMCLRYSFNMVKEADDLEKAIANVLDKGIRTGDIMADGCRQVGTVEMGEAILAEF 365 Query: 360 A 360 Sbjct: 366 K 366 >UniRef50_Q55BI2 Isocitrate dehydrogenase [NAD] regulatory subunit A, mitochondrial n=35 Tax=Eukaryota RepID=IDHA_DICDI Length = 354 Score = 378 bits (972), Expect = e-103, Method: Composition-based stats. Identities = 119/365 (32%), Positives = 174/365 (47%), Gaps = 36/365 (9%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPAT 61 SK + ++PGDGIGPE+ +V AV+ + G + Sbjct: 21 SKIQKVTLIPGDGIGPEISESVKRVFSAVKAPIEWETVVVDANTG----------ISKEV 70 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 +E + L G + P + L LRK F L++N+RP G Sbjct: 71 IESISKNKIGLKGPISTPIG-------TGHQSLNLGLRKTFNLYANIRPCLSIPG----- 118 Query: 122 PLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFE 181 N + + VRE T G Y G E A ++ + RIA AF+ Sbjct: 119 ---HKTRYNNVNTVVVRENTEGEYSG----IENQPVKGVAQSIKIITKEASTRIAHYAFQ 171 Query: 182 SARKR-RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQ 239 A R KVT I KAN+++ S L+ + E++T YP ++ + IDN MQL+ DP+Q Sbjct: 172 YALANGRKKVTCIHKANIMKQSDGLFVKSCREVSTRYPSIKYEELTIDNNCMQLVLDPNQ 231 Query: 240 FDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPI 299 DV++ NL+GDI+SD CA + G +G+ PS ++ E G ++E G+APDIAGKN ANP Sbjct: 232 MDVMVLPNLYGDIVSDLCAGLIGGLGLTPSGNIGENGSAIFEAVHGTAPDIAGKNKANPT 291 Query: 300 AQILSLALLLRYSLDADDAACAIERAINRALEEG-IRTGDLARGAAAVSTDEMGDIIARY 358 A ILS ++LR+ L A IE A+ L EG ++TGDL S E D + + Sbjct: 292 ALILSSIMMLRH-LGHFHEASIIENAVLNTLTEGKVKTGDL---GGNSSCSEYTDELVKK 347 Query: 359 VAEGV 363 + E + Sbjct: 348 ITESL 352 >UniRef50_Q2VZV2 3-isopropylmalate dehydrogenase n=35 Tax=Bacteria RepID=LEU3_MAGSA Length = 369 Score = 376 bits (967), Expect = e-103, Method: Composition-based stats. Identities = 181/364 (49%), Positives = 247/364 (67%), Gaps = 10/364 (2%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 + +LPGDGIG EVM Q +++D + + + + +GGAA D HG P P T+E Sbjct: 5 KLLILPGDGIGVEVMAQVRRIIDWMGRKRKIEFEITEGLLGGAAYDVHGTPYPAETLEAA 64 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 ADAVL G+VGGPKW+ LP D++PERG LL +RK LF+NLRPA + + L L+A Sbjct: 65 LAADAVLLGAVGGPKWDDLPFDKKPERG-LLGIRKDMGLFANLRPATVLEALADASTLKA 123 Query: 126 DIAANGFDILCVRELTGGIYFGQPKGREG-SGQYEKAFDTEVYHRFEIERIARIAFESAR 184 ++ + G DI+ +RELTGG+YFGQP+G + K ++T VY EI+RI R+AF+ AR Sbjct: 124 EVVS-GLDIMILRELTGGLYFGQPRGIDTLPDGTRKGYNTLVYTTPEIQRIGRVAFDLAR 182 Query: 185 KRRHKVTSIDKANVLQSSILWREIVNEIAT-EYPDVELAHMYIDNATMQLIKDPSQFDVL 243 KR K+ S+DKANVL+ ++LWRE + ++ E+PDVEL HMY+DNA MQL+++P QFDV+ Sbjct: 183 KRNKKLCSVDKANVLECTVLWREEMIKLQKEEFPDVELTHMYVDNAAMQLVRNPKQFDVM 242 Query: 244 LCSNLFGDILSDECAMITGSMGMLPSASLNE-----QGFGLYEPAGGSAPDIAGKNIANP 298 + N+FGDILSD AM+TGS+GMLPSASL E + LYEP GSAPDIAGK++ANP Sbjct: 243 VTENMFGDILSDCAAMLTGSLGMLPSASLGEADAQGKRKALYEPVHGSAPDIAGKDMANP 302 Query: 299 IAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAA-VSTDEMGDIIAR 357 +A I+S A+ LRYS D A IE A+ L+ G+RT D+ + A VST MG+ + R Sbjct: 303 LATIMSFAMCLRYSFDMAAEADLIETAVKNVLKGGLRTADIMQPGKAKVSTTVMGEAVVR 362 Query: 358 YVAE 361 + + Sbjct: 363 ELDK 366 >UniRef50_A3P147 Tartrate dehydrogenase n=59 Tax=Bacteria RepID=A3P147_BURP0 Length = 396 Score = 376 bits (965), Expect = e-103, Method: Composition-based stats. Identities = 144/368 (39%), Positives = 194/368 (52%), Gaps = 18/368 (4%) Query: 1 MS-KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDV-GGAAIDNHGQPLP 58 MS K Y IAV+PGDGIG EVM + L+ LDAV RF +R + HGQ +P Sbjct: 36 MSEKVYRIAVIPGDGIGVEVMPEGLRALDAVSRRFGLRFAYEPIEWASCDYYAKHGQMMP 95 Query: 59 PATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLE 118 DA+LFG+VG W PD G+L+ R+ F + NLRPA+L+ G+ Sbjct: 96 DDWKTQLSGMDALLFGAVG---WPETVPDHISLWGSLIKFRREFDQYVNLRPARLFDGVP 152 Query: 119 AFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARI 178 CPL A A D + VRE T G Y + E V+ R ER+ + Sbjct: 153 --CPL-AGRKAGDIDFMIVRENTEGEYSAVGGTMFEGTEREFVVQQAVFTRHGTERVLKF 209 Query: 179 AFESARKRRHKVTSIDKAN-VLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDP 237 AFE A++R ++T K+N + S W E+A YPDV +ID + + P Sbjct: 210 AFELAQRRAKRLTVATKSNGIAISMPWWDARAAEMAARYPDVAWDKQHIDILCARFVMQP 269 Query: 238 SQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQG--FGLYEPAGGSAPDIAGKNI 295 +FDV++ SNLFGDILSD TG++G+ PSA+LN + L+EP GSAPDIAGK+I Sbjct: 270 DRFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERNFPSLFEPVHGSAPDIAGKHI 329 Query: 296 ANPIAQILSLALLLRYSLD----ADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEM 351 ANPIA I S A+++ + A +A AI AI L+ G RT D+ ST E+ Sbjct: 330 ANPIAMIWSAAMMVDFLGAGTGPAREAHDAIVAAIEHVLKHGPRTRDM---GGRASTREV 386 Query: 352 GDIIARYV 359 GD I ++ Sbjct: 387 GDAIVAHL 394 >UniRef50_A4IK21 Tartrate dehydrogenase n=7 Tax=Bacillaceae RepID=A4IK21_GEOTN Length = 357 Score = 375 bits (963), Expect = e-102, Method: Composition-based stats. Identities = 136/365 (37%), Positives = 196/365 (53%), Gaps = 18/365 (4%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVR-NRFAMRITTSHYDVGGAAIDNHGQPLPPAT 61 + + IAVLPGDGIGPEVM +ALKVL ++ + + + HG+ +P Sbjct: 2 REFRIAVLPGDGIGPEVMNEALKVLRILKDKDYTFQFHADMFLWNSEYYLQHGRMMPENG 61 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 ++ + DA+LFG++G P+ PD ++P+RK F + NLRP K +G+ Sbjct: 62 LDILKNYDAILFGAIGDPR----VPDDISVWELIMPIRKRFCQYVNLRPVKKLKGI---- 113 Query: 122 PLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFE 181 P + + + VRE G Y E A + R ERIAR AF+ Sbjct: 114 PEQFIHQERPINFVIVRENAEGEYSNSGGRIYQGTDQEIAVQNTIITRKGTERIARYAFQ 173 Query: 182 SARKRR-HKVTSIDKAN-VLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQ 239 A+K KV + K+N V+ S LW E++ +A+EYPD++L YID ++ P Sbjct: 174 YAKKHGYQKVINATKSNAVVHSMKLWDEVIEHVASEYPDIQLEKYYIDALAAYFVQRPDT 233 Query: 240 FDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGF--GLYEPAGGSAPDIAGKNIAN 297 V++ SNLFGDILSD + + G +G+ PSA++N +G ++EP GSAPDIAGK AN Sbjct: 234 LQVIVASNLFGDILSDLGSALVGGLGISPSANINPEGVFPSMFEPVHGSAPDIAGKGKAN 293 Query: 298 PIAQILSLALLLRYSLDADDAACAIERAINRALEEG-IRTGDLARGAAAVSTDEMGDIIA 356 PIAQI S AL+L+ SL +D A I +AI + E G T DL +T EMG+ I Sbjct: 294 PIAQIWSAALMLQ-SLGREDLASIILKAIEKVTEHGEKLTEDL---GGNSTTAEMGEEIV 349 Query: 357 RYVAE 361 R + + Sbjct: 350 RQIVK 354 >UniRef50_Q2RV53 3-isopropylmalate dehydrogenase n=103 Tax=Bacteria RepID=LEU3_RHORT Length = 370 Score = 374 bits (962), Expect = e-102, Method: Composition-based stats. Identities = 172/369 (46%), Positives = 236/369 (63%), Gaps = 10/369 (2%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPA 60 M + I L GDGIGPEVM Q +V+D + VGGAA D G PL Sbjct: 1 MPVSKKILFLAGDGIGPEVMAQVRRVMDWLNQTGRTAFEVEDALVGGAAYDAQGTPLHDD 60 Query: 61 TVEGCEQADAVLFGSVGGPKWE-HLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEA 119 TV ADAVL G+VGGPKW+ LP + +PERG LL LRK +LF+NLRPA ++ L Sbjct: 61 TVALALAADAVLLGAVGGPKWDASLPFELKPERG-LLRLRKDLELFANLRPAMVFDALAE 119 Query: 120 FCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEK-AFDTEVYHRFEIERIARI 178 L+ ++ + G D++ VRELTGG+YFGQP+G E+ +T+VY EI R+A++ Sbjct: 120 ASTLKTELVS-GLDVMIVRELTGGVYFGQPRGISALPNGERRGVNTQVYDTHEIVRVAKV 178 Query: 179 AFESARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPS 238 AF+ A KR ++ S++KANV++S +LWRE V ++ +YP++ L+HMY DN MQL++ P Sbjct: 179 AFDLAGKRGKRLCSVEKANVMESGLLWREEVTKLGADYPEIALSHMYADNCAMQLVRQPK 238 Query: 239 QFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNE-----QGFGLYEPAGGSAPDIAGK 293 QFDV++ NLFGDILSD AM+TGS+GMLPSASL +YEP GSAPDIAG+ Sbjct: 239 QFDVIVTDNLFGDILSDCAAMLTGSLGMLPSASLGAADAAGNRRAMYEPVHGSAPDIAGQ 298 Query: 294 NIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAA-VSTDEMG 352 + ANP+A ILS +++LRYS D + A ++ A+ L +G+RTGD+ + V T MG Sbjct: 299 DKANPLATILSFSMMLRYSFDLAEEADLVDNAVRGVLAKGLRTGDIFQPGKTLVGTTGMG 358 Query: 353 DIIARYVAE 361 D + +A+ Sbjct: 359 DALLAEMAQ 367 >UniRef50_O27441 3-isopropylmalate dehydrogenase n=30 Tax=Archaea RepID=LEU3_METTH Length = 329 Score = 374 bits (960), Expect = e-102, Method: Composition-based stats. Identities = 135/360 (37%), Positives = 195/360 (54%), Gaps = 35/360 (9%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATV 62 K+ IAV+PGDGIG EVM AL +L+ + + + H D G A + G LP T+ Sbjct: 2 KSMKIAVIPGDGIGVEVMEAALHILNTL----DLDLEFIHADAGDACLKRTGTALPEETL 57 Query: 63 EGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 E +A A LFG+ G + ++ LR+ F LF+NLRP K G+ P Sbjct: 58 EAVGEARATLFGAAG-----------ESAADVIVRLRREFDLFANLRPVKSLPGVPCLYP 106 Query: 123 LRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFES 182 D + VRE T +Y G + E A + R RI++ AF+ Sbjct: 107 --------DLDFVIVRENTEDLYVGDEEYTP-----EGAVAKRIITRTASRRISQFAFQY 153 Query: 183 ARK-RRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQF 240 A+K KVT++ KANVL+ + ++R+ ++A+EYP +E Y+D M LI P +F Sbjct: 154 AQKEGMQKVTAVHKANVLKKTDGIFRDEFYKVASEYPQMEATDYYVDATAMYLITQPQEF 213 Query: 241 DVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIA 300 ++ +NLFGDILSDE A + G +G+ PSA++ E+ L+EP GSAP IAGKNIANP A Sbjct: 214 QTIVTTNLFGDILSDEAAGLIGGLGLAPSANIGEKN-ALFEPVHGSAPQIAGKNIANPTA 272 Query: 301 QILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYVA 360 IL+ L+L++ L+ A IE+A+ + L EG+ T DL + T EM IAR++ Sbjct: 273 MILTTTLMLKH-LNKKQEAQKIEKALQKTLAEGLVTPDL---GGKLGTMEMAAEIARHLE 328 >UniRef50_Q46FW0 3-isopropylmalate dehydrogenase n=11 Tax=Euryarchaeota RepID=Q46FW0_METBF Length = 338 Score = 373 bits (959), Expect = e-102, Method: Composition-based stats. Identities = 125/358 (34%), Positives = 194/358 (54%), Gaps = 29/358 (8%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 +AV+ GDGIG E++ A+KVLDA F + ++G + G + +E Sbjct: 2 RLAVIEGDGIGREIIPAAVKVLDA----FGLEFEKVPLELGYTRWERTGTAISNNDLETI 57 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 + DAVLFG++ + + LL +RK L++N+RP K G+ Sbjct: 58 KGCDAVLFGAITTVPDPN-------YKSVLLTIRKELDLYANVRPVKPLPGITGVT---- 106 Query: 126 DIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARK 185 N FD + VRE T G+Y G + E ++ V R ERIA A + A+K Sbjct: 107 --GRNDFDFIIVRENTEGLYSGIEEI-----GPELSWTKRVVTRKGSERIAEYACKLAKK 159 Query: 186 RRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLLC 245 R++K+T + K+NVL+S L+ ++ + A+ VE M +D+ LI P ++D+++ Sbjct: 160 RKNKLTIVHKSNVLKSDKLFLDVCRQTASA-NGVEYEDMLVDSMAYNLIMRPERYDIVVT 218 Query: 246 SNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSL 305 +NLFGDILSD CA + GS+G++PSA++ E+ + +EP GSAPDIAGK IANP+A IL + Sbjct: 219 TNLFGDILSDMCAALVGSLGLVPSANIGEK-YAFFEPVHGSAPDIAGKGIANPLAAILCV 277 Query: 306 ALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYVAEGV 363 +LL + + + I+ AI L++ I T DL ST E+G+ +A YV + Sbjct: 278 KMLLEWMGEPR--SQIIDEAIAYVLQKKIITPDL---GGTASTMEVGNAVAEYVLSNI 330 >UniRef50_Q2JUI3 Isopropylmalate/isohomocitrate dehydrogenase family protein n=19 Tax=Bacteria RepID=Q2JUI3_SYNJA Length = 368 Score = 372 bits (956), Expect = e-101, Method: Composition-based stats. Identities = 122/375 (32%), Positives = 185/375 (49%), Gaps = 39/375 (10%) Query: 5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEG 64 Y + ++PGDGIGPEV VL+A + + + G I+ +G PLPP +E Sbjct: 3 YRVTLIPGDGIGPEVTRAMTTVLEA----SGVDLEWIRVEAGVEVIEKYGTPLPPQVLES 58 Query: 65 CEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 + + G +G P R + +RK L++NLRPAK G+++ Sbjct: 59 IRETRVAIKGPIGTPVGTGF-------RSVNVAIRKELDLYANLRPAKSLPGIKSPF--- 108 Query: 125 ADIAANGFDILCVRELTGGIYFGQPKGREGSGQY----------------EKAFDTEVYH 168 D++ VRE T +Y G R A + Sbjct: 109 -----QDIDLVVVRENTEDLYAGIEFERGTPEAAHAREEMMRLSGKFIREGSAIGIKPIS 163 Query: 169 RFEIERIARIAFESARKR-RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYI 226 F RI + AFE AR+ R KVT++ KAN+++ + L+ ++ E+A EYPD+E + + Sbjct: 164 EFGSRRIVKFAFEYARQNGRKKVTAVHKANIMKFTDGLFLQVAREVAQEYPDIEFEDLIV 223 Query: 227 DNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGS 286 DN +QL++ P +DVL+ +NL+GDI+SD CA + G +G+ P A++ + G ++E GS Sbjct: 224 DNMCLQLMQKPQLYDVLVLTNLYGDIISDLCAGMIGGLGVAPGANIGD-GIAVFEAIHGS 282 Query: 287 APDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAV 346 AP AG+N NP A ILS A++LRY + + AA + E T DLA+ V Sbjct: 283 APKYAGQNKVNPSALILSGAMMLRYLGEREAAARVEAAVQSVIAEGKYVTYDLAQ-GEPV 341 Query: 347 STDEMGDIIARYVAE 361 T EM + IA V E Sbjct: 342 GTQEMAEAIAARVQE 356 >UniRef50_Q1IJA8 Isocitrate dehydrogenase (NAD+) n=19 Tax=Bacteria RepID=Q1IJA8_ACIBL Length = 348 Score = 371 bits (954), Expect = e-101, Method: Composition-based stats. Identities = 123/360 (34%), Positives = 186/360 (51%), Gaps = 33/360 (9%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 Y I ++PGDGIGPEV + A++VL+A ++ + G A + + + +P E Sbjct: 2 TYKITLIPGDGIGPEVTSAAVRVLEAT----GLKFEWESFAAGAEAYEKYKEYIPKELNE 57 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 E+ L G V P + LRK F+L++N+RP + G+ P Sbjct: 58 SIERTRIGLKGPVTTPIGGGFS-------SINVELRKRFELYANVRPIRNLPGVHTRYP- 109 Query: 124 RADIAANGFDILCVRELTGGIYFG-QPKGREGSGQYEKAFDTEVYHRFEIERIARIAFES 182 G D++ VRE T G+Y G + + G + ++ RI++ AF Sbjct: 110 -------GVDLVVVRENTEGLYSGIEHEVVPGVVE-----SLKIITEKASTRISKFAFNY 157 Query: 183 ARK-RRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQF 240 ARK R K+ SI KAN+++ S L+ I+ EYP++ +DN MQL+ +P Q+ Sbjct: 158 ARKMGRKKIHSIHKANIMKMSDGLFIRCSRNISKEYPEIIYGEHIVDNTCMQLVMNPYQY 217 Query: 241 DVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIA 300 D+LL NL+GDI+SD CA + G +G+ P A++ E+ ++E GSAPDIAGKNIANP A Sbjct: 218 DILLLENLYGDIVSDLCAGLVGGLGLAPGANIGERA-SIFEAVHGSAPDIAGKNIANPTA 276 Query: 301 QILSLALLLRYSLDADDAACAIERAINRALEEGIR-TGDLARGAAAVSTDEMGDIIARYV 359 I S L+LR+ LD DAA ++ A++ EG T D+ ST E D + + Sbjct: 277 VIRSGILMLRH-LDEQDAANRVKAAVHHVYREGKHLTRDM---GGTTSTSEFADKVVEAI 332 >UniRef50_Q1ARE1 3-isopropylmalate dehydrogenase n=2 Tax=Bacteria RepID=Q1ARE1_RUBXD Length = 355 Score = 369 bits (947), Expect = e-100, Method: Composition-based stats. Identities = 170/346 (49%), Positives = 222/346 (64%), Gaps = 10/346 (2%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPA 60 MS+ + + +LPGDGIGPEV+ A +V DA RF + + +G AAI G P+ Sbjct: 1 MSQRFRVLLLPGDGIGPEVVAAARRVADAAAARFGLTLEYEERRIGAAAIREEGAPVSKE 60 Query: 61 TVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAF 120 T+ +ADAVL G+VG P+++ + +PE G LL LR+ F+NLRP L Sbjct: 61 TLRRAGEADAVLLGAVGDPEFDG--GEVRPEAG-LLALRRELGTFANLRPVAAIPALSGS 117 Query: 121 CPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAF 180 PLR + A G D+L VRELTGG YFG+ + E+A D VY R E+ER+AR+AF Sbjct: 118 SPLRPGV-AEGVDLLIVRELTGGAYFGEKEE-----GEERASDLSVYTRGEVERVARVAF 171 Query: 181 ESARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQF 240 E+AR RR +V S+DKANVL +S LWR +V E+A +YPDV L H+ +D A M L+ DP +F Sbjct: 172 EAARGRRGRVASVDKANVLATSRLWRRVVGEVARDYPDVALEHVLVDAAAMHLVTDPGRF 231 Query: 241 DVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQG-FGLYEPAGGSAPDIAGKNIANPI 299 DV+L NLFGDILSDE A++ GSMGMLPSASL E G G++EP GSAPDIAGK +ANP Sbjct: 232 DVILTENLFGDILSDEAAVLPGSMGMLPSASLGEPGSPGIFEPVHGSAPDIAGKGVANPY 291 Query: 300 AQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAA 345 A ILS A++ R+ L +AA AIER + A+ G T DL + Sbjct: 292 AAILSAAMMFRHGLGRPEAAEAIERGVEAAVAAGCLTPDLGGSSGT 337 >UniRef50_D2EFL9 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Parvarchaeum acidiphilum ARMAN-4 RepID=D2EFL9_9EURY Length = 339 Score = 369 bits (947), Expect = e-100, Method: Composition-based stats. Identities = 122/360 (33%), Positives = 193/360 (53%), Gaps = 25/360 (6%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPAT 61 +K + +AV+ GDG+GP+V+ +L VLDAV+ +F + I G ++ +G LP T Sbjct: 3 NKKWRVAVIKGDGVGPDVINASLLVLDAVKKKFNLDIEYVPAVAGLNTVEKYGTNLPKET 62 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 ++ ++ D VL G P+ + P A + +RK+F L++++RP K + + Sbjct: 63 LDTLKETDCVLKGPTTTPEGANSLP------SANVGIRKYFDLYADVRPNKTLPNVPSIK 116 Query: 122 PLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFE 181 P D++ VRE T G+Y G + E V R ERI + AF+ Sbjct: 117 P--------NVDMVIVRENTEGMYSG----LDFRVNQETTIGIRVITRKACERIVKYAFK 164 Query: 182 SARKRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQF 240 A R+ VT + K NVL+ S ++++I E A ++PDV+ ++D T IK P + Sbjct: 165 LAESRKKHVTLVHKGNVLKVSDGMFKDIFYEEAKKHPDVKADDAHVDAITQWFIKQPEFY 224 Query: 241 DVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIA 300 DV++ NLFGDI+SDE AM+ G +G SA++ ++ + ++EP GS P G + NPI Sbjct: 225 DVIVTENLFGDIISDEAAMVVGGIGTGASANIGDK-YAMFEPIHGSVPKYTGMDKVNPIG 283 Query: 301 QILSLALLLRYSLDADDAACAIERAINRALEEG-IRTGDLARGAAAVSTDEMGDIIARYV 359 I+S+ ++L + +D +A AIE A+ + LEEG I T DL A E+G IA V Sbjct: 284 TIMSVKMMLDW-MDYKEAGKAIEDAVYKVLEEGKILTYDLGGTAK---CSEVGKEIASKV 339 >UniRef50_Q58991 Homoisocitrate dehydrogenase n=21 Tax=Euryarchaeota RepID=AKSF_METJA Length = 347 Score = 368 bits (945), Expect = e-100, Method: Composition-based stats. Identities = 128/363 (35%), Positives = 198/363 (54%), Gaps = 26/363 (7%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 + V+ GDGIG EV+ +A+K+L+ + + G + +G LP T+E Sbjct: 3 KVCVIEGDGIGKEVIPEAIKILNELG-----EFEIIKGEAGLECLKKYGNALPEDTIEKA 57 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 ++AD +LFG++ PK P + + + ++ LRK F L++N+RP + G+ A Sbjct: 58 KEADIILFGAITSPK----PGEVKNYKSPIITLRKMFHLYANVRPINNF-GIGQLIGKIA 112 Query: 126 D---IAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFES 182 D + A DI+ +RE T +Y G+ + + + A V R ERI R AFE Sbjct: 113 DYEFLNAKNIDIVIIRENTEDLYVGRERL-----ENDTAIAERVITRKGSERIIRFAFEY 167 Query: 183 A-RKRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQF 240 A + R KV+ I KANVL+ + L+ E+ NEI Y ++E +D+ M LIK P +F Sbjct: 168 AIKNNRKKVSCIHKANVLRITDGLFLEVFNEIKKHY-NIEADDYLVDSTAMNLIKHPEKF 226 Query: 241 DVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIA 300 DV++ +N+FGDILSDE + + G +G+ PSA++ + L+EP GSAPDIAGK IANP+A Sbjct: 227 DVIVTTNMFGDILSDEASALIGGLGLAPSANIGDD-KALFEPVHGSAPDIAGKGIANPMA 285 Query: 301 QILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYVA 360 ILS+A+L Y + + I A+ L T DL + T ++GD I Y+ Sbjct: 286 SILSIAMLFDY-IGEKEKGDLIREAVKYCLINKKVTPDLGGD---LKTKDVGDEILNYIR 341 Query: 361 EGV 363 + + Sbjct: 342 KKL 344 >UniRef50_Q51945 Tartrate dehydrogenase/decarboxylase n=249 Tax=cellular organisms RepID=TTUC_PSEPU Length = 365 Score = 368 bits (944), Expect = e-100, Method: Composition-based stats. Identities = 124/369 (33%), Positives = 188/369 (50%), Gaps = 19/369 (5%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDV-GGAAIDNHGQPLPPA 60 + ++ IA +PGDGIG EV+ + ++VL+A + + + ++ HG+ +P Sbjct: 3 AHSFRIAAIPGDGIGLEVLPEGIRVLEAAALKHGLALEFDTFEWASCDYYLQHGKMMPDD 62 Query: 61 TVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAF 120 E +Q DA+ FG+V W PD G+LL R+ F + N+RP +L+ G+ Sbjct: 63 WAEQLKQYDAIYFGAV---DWPDKVPDHISLWGSLLKFRREFDQYVNIRPVRLFPGVPCA 119 Query: 121 CPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAF 180 A+ D + VRE T G Y + + E ++ R ++RI + AF Sbjct: 120 L---ANRKVGDIDFVVVRENTEGEYSSLGGIMFENTENEIVIQESIFTRRGVDRILKYAF 176 Query: 181 ESARKR-RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPS 238 + A KR R VTS K+N + S W + +A YP V +ID + + P Sbjct: 177 DLAEKRERKHVTSATKSNGMAISMPYWDKRTEAMAAHYPHVSWDKQHIDILCARFVLQPE 236 Query: 239 QFD-VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQG--FGLYEPAGGSAPDIAGKNI 295 +FD V++ SNLFGDILSD G++G+ PSA+LN + L+EP GSAPDI GKNI Sbjct: 237 RFDVVVVASNLFGDILSDLGPACAGTIGIAPSANLNPERNFPSLFEPVHGSAPDIFGKNI 296 Query: 296 ANPIAQILSLALLLRYSLDADD----AACAIERAINRALEEGIRTGDLARGAAAVSTDEM 351 ANPIA I S AL+L + D+ A + AI R + +G T D+ +ST ++ Sbjct: 297 ANPIAMIWSGALMLEFLGQGDERYQRAHDDMLNAIERVIADGSVTPDM---GGTLSTQQV 353 Query: 352 GDIIARYVA 360 G I+ +A Sbjct: 354 GAAISDTLA 362 >UniRef50_C4Q3D3 Unc-13 (Munc13), putative n=38 Tax=cellular organisms RepID=C4Q3D3_SCHMA Length = 2313 Score = 366 bits (941), Expect = e-100, Method: Composition-based stats. Identities = 103/360 (28%), Positives = 174/360 (48%), Gaps = 31/360 (8%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 +A++PGDGIGPE+ ++ + I DV ++ +P ++++ Sbjct: 1978 TVALIPGDGIGPEISAAVQEIFKFA----DVPIKWESVDVTPRPTEDGRFRMPQSSLDII 2033 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 + L G + P + + L LRK F L++N+RP K +G Sbjct: 2034 RKHGIGLKGPLATPIG-------KGHQSLNLALRKEFNLYANVRPCKSIEG--------Y 2078 Query: 126 DIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARK 185 + D++ VRE T G Y G E ++ R+AR AF+ A+ Sbjct: 2079 ETPYKNVDLVTVRENTEGEYSG----IEHVIVDGVVQSIKLITEEASRRVARFAFQYAKD 2134 Query: 186 R-RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVL 243 R VT++ KAN+++ S L+ + E A + ++E M++D + L++DP++FDVL Sbjct: 2135 NGRRSVTAVHKANIMRMSDGLFLRVCREEAAHHREIEFCDMFLDTVCLNLVQDPTRFDVL 2194 Query: 244 LCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQIL 303 + NL+GDILSD A + G +G+ PS ++ E G ++E G+APDIAG++ ANP A + Sbjct: 2195 VMPNLYGDILSDLAAGLIGGLGVTPSGNIGETG-AIFESVHGTAPDIAGQDRANPTALLF 2253 Query: 304 SLALLLRYSLDADDAACAIERAINRALEE-GIRTGDLARGAAAVSTDEMGDIIARYVAEG 362 S ++LRY ++ + A IE A+ + E T DL + + I R + + Sbjct: 2254 SAIMMLRY-MNLNKHADLIESAVLATIREAKYLTADL---GGRSTCSQYTKEICRQIEQK 2309 >UniRef50_P42958 Probable tartrate dehydrogenase/decarboxylase n=8 Tax=Bacteria RepID=TTUC_BACSU Length = 354 Score = 366 bits (941), Expect = e-100, Method: Composition-based stats. Identities = 124/363 (34%), Positives = 188/363 (51%), Gaps = 17/363 (4%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLD-AVRNRFAMRITTSHYDVGGAAIDNHGQPLPPAT 61 K + IA +PGDG+G EV+ A KVL A + + + + HG+ +P Sbjct: 4 KQFEIAAIPGDGVGKEVVAAAEKVLHTAAEVHGGLSFSFTAFPWSCDYYLEHGKMMPEDG 63 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 + Q +AV G+VG PK L PD G LL +R+ +L N+RPAK G+ + Sbjct: 64 IHTLTQFEAVFLGAVGNPK---LVPDHISLWGLLLKIRRELELSINMRPAKQMAGITSPL 120 Query: 122 PLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFE 181 + N FD + +RE + G Y + GR G E A V+ R ER+ R AFE Sbjct: 121 -----LHPNDFDFVVIRENSEGEYS-EVGGRIHRGDDEIAIQNAVFTRKATERVMRFAFE 174 Query: 182 SARKRRHKVTSIDKAN-VLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQF 240 A+KRR VTS K+N + + W E+ + A +Y +E + +ID + P F Sbjct: 175 LAKKRRSHVTSATKSNGIYHAMPFWDEVFQQTAADYSGIETSSQHIDALAAFFVTRPETF 234 Query: 241 DVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQG--FGLYEPAGGSAPDIAGKNIANP 298 DV++ SNLFGDIL+D + + GS+G+ PSA++N G ++EP GSAPDIAG+ +ANP Sbjct: 235 DVIVASNLFGDILTDISSSLMGSIGIAPSANINPSGKYPSMFEPVHGSAPDIAGQGLANP 294 Query: 299 IAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARY 358 I QI + L+L + ++ I + + +GI+T D+ +T E+ D I Sbjct: 295 IGQIWTAKLMLDH-FGEEELGAKILDVMEQVTADGIKTRDI---GGQSTTAEVTDEICSR 350 Query: 359 VAE 361 + + Sbjct: 351 LRK 353 >UniRef50_P70787 Probable tartrate dehydrogenase/decarboxylase ttuC n=117 Tax=cellular organisms RepID=TTUC2_AGRVI Length = 364 Score = 365 bits (938), Expect = 1e-99, Method: Composition-based stats. Identities = 118/363 (32%), Positives = 185/363 (50%), Gaps = 16/363 (4%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFA-MRITTSHYDVGGAAIDNHGQPLPPAT 61 + Y IA +P DGIGPEV+ L+VL+A+ R I T +D G +G +P Sbjct: 2 REYKIAAIPADGIGPEVIAAGLQVLEALEKRSGDFSIHTETFDWGSDYYKKNGVMMPADG 61 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 +E ++ DA+ FG+VG P PD G LP+ + F ++N+RP K+ G+ Sbjct: 62 LEQLKKFDAIFFGAVGAPD----VPDHITLWGLRLPICQGFDQYANVRPTKVLPGI---T 114 Query: 122 PLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFE 181 P + D + VRE + G Y G E + ++ R + RI R AF+ Sbjct: 115 PPLRNCGPGDLDWVIVRENSEGEYSGHGGRAHKGLPEEVGTEVAIFTRVGVTRIMRYAFK 174 Query: 182 SARKR-RHKVTSIDKANVLQSSI-LWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQ 239 A+ R R +T + K+N + + +W EI E++ E+PDV M +D T+++ P Sbjct: 175 LAQARPRKLLTVVTKSNAQRHGMVMWDEIAAEVSKEFPDVTWDKMLVDAMTVRMTLKPQS 234 Query: 240 FDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQG--FGLYEPAGGSAPDIAGKNIAN 297 D ++ +NL DILSD + GS+G+ P+A+++ + ++EP GSA DI GK IAN Sbjct: 235 LDTIVATNLHADILSDLAGALAGSLGVAPTANIDPERRFPSMFEPIHGSAFDITGKGIAN 294 Query: 298 PIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIAR 357 P+A + A +L + L DAA + A+ R E GI T D+ A T ++ D + Sbjct: 295 PVATFWTAAQMLEH-LGEKDAATRLMSAVERVTEAGILTPDVGGTAD---TQQVTDAVCE 350 Query: 358 YVA 360 +A Sbjct: 351 AIA 353 >UniRef50_B8N3I6 Tartrate dehydrogenase, putative n=3 Tax=Trichocomaceae RepID=B8N3I6_ASPFN Length = 398 Score = 364 bits (936), Expect = 2e-99, Method: Composition-based stats. Identities = 121/362 (33%), Positives = 191/362 (52%), Gaps = 17/362 (4%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFA-MRITTSHYDVGGAAIDNHGQPLPPATV 62 Y IA +PGDGIG EV+ A++V++ + I +H G A HG+ + + Sbjct: 46 TYRIASIPGDGIGIEVVDAAIQVVEKLAKTLGTFNIDFTHIPWGTAYYKEHGRYVSEDCL 105 Query: 63 EGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 + + DA LFG+VG P PD G LL LR +L++N+RP + + G CP Sbjct: 106 DTLRKFDAGLFGAVGAPD----VPDHISLWGLLLALRGPLQLYANVRPVRTFPG--TKCP 159 Query: 123 LRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFES 182 L + A G D + VRE + G Y GQ +E A + ++ R IERI R AFE Sbjct: 160 L--NTATEGIDWMLVRENSEGEYSGQGGRSHVGQPWEAATEVAMFTRVGIERIMRFAFEV 217 Query: 183 ARKR-RHKVTSIDKANVLQSSI-LWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQF 240 A+ R R +T + K+N +++ + LW ++ E+A ++PDV M +D T++++ P Sbjct: 218 AQSRPRKLLTVVTKSNSMRNGMVLWDQVAAEVAKDFPDVTWDKMLVDAMTVRMVAKPQSI 277 Query: 241 DVLLCSNLFGDILSDECAMITGSMGMLPSASLNE--QGFGLYEPAGGSAPDIAGKNIANP 298 D ++ +NL DILSD A + GS+G+ PS++L+ + ++EP GSA DI GK +ANP Sbjct: 278 DTIVGTNLHMDILSDLAAALAGSIGVAPSSNLDPTRKNPSIFEPVHGSAFDITGKGVANP 337 Query: 299 IAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARY 358 +A S A +L + L +AA + + + GI T DL +T + D + + Sbjct: 338 VATFWSAAEMLSW-LGEKEAAKQLMDCVEKVCAAGILTPDL---GGTSNTQGVVDAVKKE 393 Query: 359 VA 360 + Sbjct: 394 IE 395 >UniRef50_B3TCK6 Putative isocitrate/isopropylmalate dehydrogenase n=2 Tax=environmental samples RepID=B3TCK6_9ARCH Length = 339 Score = 363 bits (931), Expect = 8e-99, Method: Composition-based stats. Identities = 118/367 (32%), Positives = 193/367 (52%), Gaps = 36/367 (9%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPA 60 MS Y+I+++ GDGIGPE+ AL +L+A+ + F + + + G A + N G+ LP Sbjct: 1 MSGKYNISLVTGDGIGPEISESALSILEAINDNFPLSLEIKKLEAGDAVLKNTGKALPDE 60 Query: 61 TVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAF 120 T E + +DA L VG + + ++ LR+ L++N+RPAK Y + + Sbjct: 61 TFEAIKNSDACLKAPVG-----------ESAKDVIVYLRRMLDLYANIRPAKSYPNMPSL 109 Query: 121 CPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAF 180 + D++ VRE T +Y G+ + A + +RIA AF Sbjct: 110 --------RDDVDLVIVRENTEDLYTGEEF-----DIGDAAVAFRIISEKASKRIANYAF 156 Query: 181 ESARKRR-HKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPS 238 A KR+ KVT + K+NV++ + L+ +++A ++PDV+ MY+D M LI+ P Sbjct: 157 TIASKRKMKKVTCVHKSNVMKKTDGLFARTCSKVANDFPDVKFEEMYVDACAMNLIRQPQ 216 Query: 239 QFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANP 298 FDV++ +NLFGDILSDE A + G +GM P+A++ + FGL+EP G+A DIAGK IANP Sbjct: 217 LFDVIVTTNLFGDILSDESAQVVGGLGMAPAANIGDN-FGLFEPVHGAAFDIAGKQIANP 275 Query: 299 IAQILSLALLLRYSLDAD------DAACAIERAINRALEEGIRTGDLARGAAAVSTDEMG 352 + ILS+ ++L + + + +E + ++ I+T D+ +T E Sbjct: 276 TSFILSIKMMLDWLGNKHNDQKCIEVGQKLEDVVYDIVKNNIKTKDIGGD---KTTMEFT 332 Query: 353 DIIARYV 359 I + Sbjct: 333 KEIISRL 339 >UniRef50_Q6W109 Tartrate dehydrogenase n=13 Tax=Bacteria RepID=Q6W109_RHISN Length = 347 Score = 359 bits (923), Expect = 7e-98, Method: Composition-based stats. Identities = 135/356 (37%), Positives = 189/356 (53%), Gaps = 14/356 (3%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATV 62 K+Y IA++PGDGIG +V A +VL V +T + + A G +PP + Sbjct: 2 KSYSIALIPGDGIGQDVTDAAWQVLSTVARHSGFTLTATPFPWSCAFYKETGAMMPPDGI 61 Query: 63 EGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 E + DA+L G+VG W PD G LLP+RK F ++N+RP +L G+ Sbjct: 62 ETLRRFDAILLGAVG---WPAEVPDSVSLHGLLLPIRKAFVQYANIRPHRLLSGV----- 113 Query: 123 LRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFES 182 + + A GFDILC+RE T G Y G E A +T ++ R +ERI R F+ Sbjct: 114 -KGPLKAEGFDILCIRENTEGEYSGAGGRVHQGTADEVAVETSIFTRTGVERILRFGFDQ 172 Query: 183 ARKRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFD 241 AR+RR K+ S+ K+N + S +LW EI E+A EYPDVE+ +ID +++ P D Sbjct: 173 ARQRRRKLASVTKSNAQKYSMVLWDEITRELAAEYPDVEVTSYHIDAMAARMVMAPESLD 232 Query: 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFG--LYEPAGGSAPDIAGKNIANPI 299 V++ SNLFGDIL+D A I G +G SA++N ++EP GSAPDIA IANPI Sbjct: 233 VVVASNLFGDILTDLGAAIQGGLGFAASANINPDRSAPSMFEPVHGSAPDIAHLGIANPI 292 Query: 300 AQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDII 355 A I S A++L + A A IE A+ R GI T + T + + Sbjct: 293 AAIWSGAMMLDHLGQARAARKVIE-ALERTTARGIGTVP-GKNRTETITAAVLAAL 346 >UniRef50_C1XGT6 Homoisocitrate dehydrogenase n=1 Tax=Meiothermus ruber DSM 1279 RepID=C1XGT6_MEIRU Length = 335 Score = 358 bits (920), Expect = 2e-97, Method: Composition-based stats. Identities = 126/361 (34%), Positives = 186/361 (51%), Gaps = 28/361 (7%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPA 60 MSK Y I ++ GDGIG EV+ A VL+A ++ G + G +P A Sbjct: 1 MSKTYKICLIEGDGIGHEVIPAARLVLEAT----GLKFEFVEAQAGWETFERIGTSVPEA 56 Query: 61 TVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAF 120 T+E DA LFG+ P GA+ +R+ LF+N+RPAK + + Sbjct: 57 TLEAVTHTDATLFGAATSP-----TKKVPGFFGAIRYMRRKLDLFANVRPAKHHP-VPGS 110 Query: 121 CPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAF 180 P G D++ VRE T G+Y Q + + E A V R RI A Sbjct: 111 RP--------GVDLIVVRENTEGLYVEQERSYL---EGEIAIADTVITRKASARIGEYAA 159 Query: 181 ESARKR-RHKVTSIDKANVL-QSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPS 238 A R R ++ KANVL + L+ V A +P+V+ + IDN MQL+++P Sbjct: 160 RLAASRPRKQLHVAHKANVLPMTQGLFMNTVLAEAARFPEVKTQDIIIDNCAMQLVRNPE 219 Query: 239 QFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANP 298 +FDV++ +NLFGDI+SD A + G +G+ S ++ + ++EP GSAPDIAGK IANP Sbjct: 220 RFDVIVTTNLFGDIISDLTAGLVGGLGIAASGNIGIK-HAVFEPVHGSAPDIAGKGIANP 278 Query: 299 IAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARY 358 A ILS ++L + L +AA +E A+++ L+EG RT DL A +T + + +AR Sbjct: 279 AATILSGVMMLDH-LGEHEAARRVEAAVDKVLQEGPRTPDLGGNA---TTLQFAEAVARS 334 Query: 359 V 359 + Sbjct: 335 L 335 >UniRef50_Q5SIJ1 Homoisocitrate dehydrogenase n=13 Tax=cellular organisms RepID=Q5SIJ1_THET8 Length = 334 Score = 358 bits (919), Expect = 2e-97, Method: Composition-based stats. Identities = 123/359 (34%), Positives = 181/359 (50%), Gaps = 30/359 (8%) Query: 5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEG 64 Y I ++ GDGIG EV+ A +VL+A + + + G + G +P TVE Sbjct: 3 YRICLIEGDGIGHEVIPAARRVLEAT----GLPLEFVEAEAGWETFERRGTSVPEETVEK 58 Query: 65 CEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 A LFG+ P GA+ LR+ L++N+RPAK + P Sbjct: 59 ILSCHATLFGAATSP-----TRKVPGFFGAIRYLRRRLDLYANVRPAKSRP-VPGSRP-- 110 Query: 125 ADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESAR 184 G D++ VRE T G+Y Q + + A V + ERI R A A Sbjct: 111 ------GVDLVIVRENTEGLYVEQER-----RYLDVAIADAVISKKASERIGRAALRIAE 159 Query: 185 KR-RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDV 242 R R + KANVL + L+ + V E+A ++P V + + +DN MQL+ P +FDV Sbjct: 160 GRPRKTLHIAHKANVLPLTQGLFLDTVKEVAKDFPLVNVQDIIVDNCAMQLVMRPERFDV 219 Query: 243 LLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQI 302 ++ +NL GDILSD A + G +G+ PS ++ + ++EP GSAPDIAGK IANP A I Sbjct: 220 IVTTNLLGDILSDLAAGLVGGLGLAPSGNIGDT-TAVFEPVHGSAPDIAGKGIANPTAAI 278 Query: 303 LSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYVAE 361 LS A++L Y L +AA +E+A++ LE G RT DL A +T+ + + + Sbjct: 279 LSAAMMLDY-LGEKEAAKRVEKAVDLVLERGPRTPDLGGDA---TTEAFTEAVVEALKS 333 >UniRef50_A9IDG2 Tartrate dehydrogenase n=5 Tax=cellular organisms RepID=A9IDG2_BORPD Length = 363 Score = 358 bits (919), Expect = 2e-97, Method: Composition-based stats. Identities = 113/365 (30%), Positives = 181/365 (49%), Gaps = 17/365 (4%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFA-MRITTSHYDVGGAAIDNHGQPLPPAT 61 K Y IA +PGDGIG EV+ + + + +D GG HG +P Sbjct: 2 KTYRIATIPGDGIGKEVIPAGRQAMQVLAETDGSFTFEFQDFDWGGDYYRRHGVMMPADG 61 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 +E DA+LFGS G P D G L + + ++N+RP +L G++ Sbjct: 62 LEPLRDKDAILFGSAGDPDI----ADHITLWGLRLKICQGLDQYANVRPTRLLPGIDG-- 115 Query: 122 PLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFE 181 PL+ A D + VRE + G Y G E A D + R +ERI R AF Sbjct: 116 PLKR-CTAEQLDWVIVRENSEGEYSGVGGRVHQGLPIEAATDVSMMTRAGVERILRYAFR 174 Query: 182 SARKR-RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQ 239 A+ R R ++T + K+N + + ++W EI EI+ E+PDV +D AT +++ P+ Sbjct: 175 LAQSRPRKQLTVVTKSNAQRHAMVMWDEIALEISREFPDVRWDKELVDAATARMVNRPAS 234 Query: 240 FDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQ--GFGLYEPAGGSAPDIAGKNIAN 297 D ++ +NL DILSD A + GS+G+ P+ +++ + G ++EP GSA DI GK +AN Sbjct: 235 LDTIVATNLHADILSDLAAALAGSLGIAPTGNIDPERRGPSMFEPIHGSAFDIMGKGLAN 294 Query: 298 PIAQILSLALLLRYSLDADDAACAIERAINRALEE-GIRTGDLARGAAAVSTDEMGDIIA 356 PI S+ +LL + L AA + RA+ + + T DL +T+++ + Sbjct: 295 PIGTFWSVVMLLEH-LGEHQAAARMMRAVESVTADQALHTRDL---GGTATTEQVTQAVC 350 Query: 357 RYVAE 361 +++ + Sbjct: 351 QHLRQ 355 >UniRef50_P04173 3-isopropylmalate dehydrogenase n=61 Tax=Fungi/Metazoa group RepID=LEU3_YEAST Length = 364 Score = 358 bits (918), Expect = 2e-97, Method: Composition-based stats. Identities = 166/372 (44%), Positives = 232/372 (62%), Gaps = 22/372 (5%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRN-RFAMRITTSHYDVGGAAIDNHGQPLPP 59 MS I VLPGD +G E+ +A+KVL A+ + R ++ ++ +GGAAID G PLP Sbjct: 1 MSAPKKIVVLPGDHVGQEITAEAIKVLKAISDVRSNVKFDFENHLIGGAAIDATGVPLPD 60 Query: 60 ATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKL-YQGLE 118 +E ++ADAVL G+VGGPKW +PE+G LL +RK +L++NLRP L Sbjct: 61 EALEASKKADAVLLGAVGGPKWG--TGSVRPEQG-LLKIRKELQLYANLRPCNFASDSLL 117 Query: 119 AFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARI 178 P++ A G D + VREL GGIYFG+ K +G G A+D+E Y E++RI R+ Sbjct: 118 DLSPIKPQF-AKGTDFVVVRELVGGIYFGKRKEDDGDG---VAWDSEQYTVPEVQRITRM 173 Query: 179 AFESARKRRHK--VTSIDKANVLQSSILWREIVNE-IATEYPDVELAHMYIDNATMQLIK 235 A A + + S+DKANVL SS LWR+ V E I E+P +++ H ID+A M L+K Sbjct: 174 AAFMALQHEPPLPIWSLDKANVLASSRLWRKTVEETIKNEFPTLKVQHQLIDSAAMILVK 233 Query: 236 DPSQFD-VLLCSNLFGDILSDECAMITGSMGMLPSASLN-----EQGFGLYEPAGGSAPD 289 +P+ + +++ SN+FGDI+SDE ++I GS+G+LPSASL FGLYEP GSAPD Sbjct: 234 NPTHLNGIIITSNMFGDIISDEASVIPGSLGLLPSASLASLPDKNTAFGLYEPCHGSAPD 293 Query: 290 IAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTD 349 + KN NPIA ILS A++L+ SL+ + AIE A+ + L+ GIRTGDL + ST Sbjct: 294 LP-KNKVNPIATILSAAMMLKLSLNLPEEGKAIEDAVKKVLDAGIRTGDL---GGSNSTT 349 Query: 350 EMGDIIARYVAE 361 E+GD +A V + Sbjct: 350 EVGDAVAEEVKK 361 >UniRef50_P50213 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial n=91 Tax=cellular organisms RepID=IDH3A_HUMAN Length = 366 Score = 356 bits (915), Expect = 6e-97, Method: Composition-based stats. Identities = 112/358 (31%), Positives = 172/358 (48%), Gaps = 30/358 (8%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 + ++PGDGIGPE+ +K+ DA + I +V +P E Sbjct: 33 TVTLIPGDGIGPEISAAVMKIFDAAKA----PIQWEERNVTAIQGPGGKWMIPSEAKESM 88 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 ++ L G + P P L LRK F L++N+RP +G + Sbjct: 89 DKNKMGLKGPLKTPIAAGHP-------SMNLLLRKTFDLYANVRPCVSIEGYKTPYT--- 138 Query: 126 DIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARK 185 +I+ +RE T G Y G E ++ +RIA AFE AR Sbjct: 139 -----DVNIVTIRENTEGEYSG----IEHVIVDGVVQSIKLITEGASKRIAEFAFEYARN 189 Query: 186 R-RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVL 243 R VT++ KAN+++ S L+ + E+A D++ MY+D + +++DPSQFDVL Sbjct: 190 NHRSNVTAVHKANIMRMSDGLFLQKCREVAESCKDIKFNEMYLDTVCLNMVQDPSQFDVL 249 Query: 244 LCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQIL 303 + NL+GDILSD CA + G +G+ PS ++ G ++E G+APDIAGK++ANP A +L Sbjct: 250 VMPNLYGDILSDLCAGLIGGLGVTPSGNIGANGVAIFESVHGTAPDIAGKDMANPTALLL 309 Query: 304 SLALLLRYSLDADDAACAIERAINRALEEGI-RTGDLARGAAAVSTDEMGDIIARYVA 360 S ++LR+ + D A IE A +++G T DL A + + I R V Sbjct: 310 SAVMMLRH-MGLFDHAARIEAACFATIKDGKSLTKDLGGNAK---CSDFTEEICRRVK 363 >UniRef50_Q12545 3-isopropylmalate dehydrogenase n=54 Tax=cellular organisms RepID=LEU3_CEPAC Length = 380 Score = 353 bits (906), Expect = 6e-96, Method: Composition-based stats. Identities = 157/383 (40%), Positives = 221/383 (57%), Gaps = 36/383 (9%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRN-RFAMRITTSHYDVGGAAIDNHGQPLPP 59 M+ Y I VLPGD IGPE+M +A+KVL + R + + VGG +ID HG P+ Sbjct: 1 MTTTYKILVLPGDHIGPEIMAEAIKVLTTIETHRPNLHFNLTTDLVGGTSIDTHGVPITQ 60 Query: 60 ATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLY-QGLE 118 + ++ + +DAVLFGS+GGP+W + P + LL LR+H F+NLRP + L Sbjct: 61 SVLDAAKASDAVLFGSIGGPEWAGVHPTPE---SGLLQLRQHLDAFANLRPCEFLVPSLV 117 Query: 119 AFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARI 178 P+R + G + VRE GG YFG+ K E + A D VY R EIER+AR+ Sbjct: 118 GASPIREHVV-KGTRFIVVRENCGGAYFGEKKEEE-----DVASDLWVYTRPEIERLARV 171 Query: 179 AFESAR--------KRRHKVTSIDKANVLQSSILWREIVNEI-ATEYPDVELAHMYIDNA 229 + AR + V S DKANVL S LWR I ++I A E+PD+ L H D+ Sbjct: 172 SAAVARIMGRSEDDNQAATVWSADKANVLASGRLWRRITSDIFAKEFPDITLQHQLADSM 231 Query: 230 TMQLIKDPSQFD-VLLCSNLFGDILSDECAMITGSMGMLPSASL------NEQGFGLYEP 282 M +++DP +F+ V+ N FGDILSD ITG++G++PSASL + G+YEP Sbjct: 232 AMLMVRDPRRFNGVIHTDNTFGDILSDISGAITGTLGLMPSASLCGVPGEGHRSNGIYEP 291 Query: 283 AGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEG------IRT 336 GSAPDI+GK +ANP+AQILS+A++LRYS+ + A A+ERA+ + L+ IRT Sbjct: 292 VHGSAPDISGKGLANPVAQILSVAMMLRYSMGLEKEATAVERAVVKVLDAKSEGGLEIRT 351 Query: 337 GDLARGAAAVSTDEMGDIIARYV 359 GDL + ++GD + + Sbjct: 352 GDL---GGRATCSQVGDAVCEVL 371 >UniRef50_B1MJY2 Tartrate dehydrogenase n=5 Tax=Bacteria RepID=B1MJY2_MYCA9 Length = 350 Score = 353 bits (906), Expect = 7e-96, Method: Composition-based stats. Identities = 132/362 (36%), Positives = 189/362 (52%), Gaps = 18/362 (4%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPA 60 MS +A +PGDGIG +V +A+KV+D+ RI + +D G +PP Sbjct: 1 MSDRMRVATIPGDGIGVDVTREAVKVMDSAT---GGRIEWTEFDYSCERYAKTGAMMPPD 57 Query: 61 TVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAF 120 DA+L G+VG P PD G L+PLR+ F + NLRP +L G+ + Sbjct: 58 APTTLAGFDAILLGAVGYPG----VPDDVSLWGLLIPLRRAFNQYVNLRPVRLLPGIASP 113 Query: 121 CPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAF 180 A ++ ++ VRE T G Y Q E A V+ R ERI R AF Sbjct: 114 L---AGVSDEALSMVIVRENTEGEYSPIGGVHNRGNQNEFALQESVFTRIGCERIIRYAF 170 Query: 181 ESARKRRHKVTSIDKAN-VLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQ 239 E A +V S K+N ++ S W I NEIA EYP M++D +++ DP+ Sbjct: 171 ELAASAGFRVCSATKSNGIIHSMPYWDSIFNEIAAEYPQTPSVSMHVDALAARMVSDPAS 230 Query: 240 FDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFG--LYEPAGGSAPDIAGKNIAN 297 DV++ SNLFGDILSD A ITG +G+ S ++N + ++E GSAPDIAG+ IAN Sbjct: 231 LDVIVASNLFGDILSDLAAAITGGLGLAASGNINPERTAISMFESVHGSAPDIAGQGIAN 290 Query: 298 PIAQILSLALLLRYSLDADDAACAIERAINRALEEG-IRTGDLARGAAAVSTDEMGDIIA 356 P+AQIL+ A+LL + L+ A I A+++ L +G +RT DL +T+++G IA Sbjct: 291 PVAQILAGAMLLDH-LNEPATANKIRLAVDQVLSDGRVRTPDL---GGTATTEQLGTAIA 346 Query: 357 RY 358 Sbjct: 347 EA 348 >UniRef50_Q2JYV7 Probable tartrate dehydrogenase protein n=7 Tax=Rhizobium etli RepID=Q2JYV7_RHIEC Length = 347 Score = 352 bits (904), Expect = 1e-95, Method: Composition-based stats. Identities = 130/335 (38%), Positives = 179/335 (53%), Gaps = 13/335 (3%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATV 62 K Y IA+LPGDGIG +V A VL+ + + Y +G +P + Sbjct: 2 KTYRIALLPGDGIGRDVTDAAWAVLEKTAGSGGFSLEATRYPWSCDYYLENGSMMPADGI 61 Query: 63 EGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 E + DA+L G+VG W PD G LLP+RK F ++N+RP +L G++ P Sbjct: 62 ETLKSFDAILLGAVG---WPRKVPDSVSLHGLLLPIRKAFVQYANIRPHRLLPGVQG--P 116 Query: 123 LRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFES 182 LR+D GFDILC+RE T G Y G E A +T ++ R +ERI R FE Sbjct: 117 LRSD----GFDILCIRENTEGEYSGAGGRIHQGADNEVAIETAIFTRKGVERILRFGFEQ 172 Query: 183 ARKRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFD 241 AR RR K+ S+ K+N + S + W EI + ++ EYPDVE+ +ID +++ P D Sbjct: 173 ARARRGKLASVTKSNAQKYSMVFWDEITHGLSAEYPDVEVTSYHIDAMAARMVMAPESLD 232 Query: 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFG--LYEPAGGSAPDIAGKNIANPI 299 V+ SNLFGDIL+D A I G +G SA++N ++EP GSAPDIA IANPI Sbjct: 233 VVAASNLFGDILTDLGAAIQGGLGFAASANINPDRSAPSMFEPVHGSAPDIAHLGIANPI 292 Query: 300 AQILSLALLLRYSLDADDAACAIERAINRALEEGI 334 A I S A++L + L AA + AI G+ Sbjct: 293 AAIWSGAMMLEH-LGETAAAEKVMDAIETTTARGV 326 >UniRef50_A1SWV5 3-isopropylmalate dehydrogenase n=1 Tax=Psychromonas ingrahamii 37 RepID=A1SWV5_PSYIN Length = 368 Score = 349 bits (896), Expect = 8e-95, Method: Composition-based stats. Identities = 149/363 (41%), Positives = 215/363 (59%), Gaps = 6/363 (1%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNR-FAMRITTSHYDVGGAAIDNHGQPLPPATV 62 Y+IA+L GDGIGPEVM +A+KVL + R + + G AA G P T Sbjct: 3 TYNIALLAGDGIGPEVMKEAVKVLKLIEQRNEDVNFELNDVLFGAAAYFAMGHAFPDETK 62 Query: 63 EGCEQADAVLFGSVG--GPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAF 120 C++ADA+L G++G + +P D+QPERGALLPLR+ + F+N RP L +GL F Sbjct: 63 AACDKADAILKGTIGLNHEDSKKIPIDEQPERGALLPLRRRYNTFANFRPVYLPKGLAHF 122 Query: 121 CPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAF 180 PL+A + G DI+ +REL GG+YFG+ + + + Y +I +I ++ F Sbjct: 123 SPLKASVIGEGIDIMIIRELVGGLYFGEKEMGVNADGKRFVREVLEYDEDQIRQIVKVGF 182 Query: 181 ESARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQF 240 E + KR+ + +I K+NVL+SS+LW EIV E + YP+VE+ ++ +D A L +P F Sbjct: 183 EVSMKRKKVMHNIHKSNVLKSSVLWNEIVEEESKNYPEVEVKNILVDAAATYLCLNPGMF 242 Query: 241 DVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIA 300 DV++ N+FGDILSD+ I GS+G++PSA YEP+ GSAPDIAGK IANP + Sbjct: 243 DVMVMENMFGDILSDQGGGILGSLGLMPSACKGPD-KSYYEPSHGSAPDIAGKGIANPYS 301 Query: 301 QILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAA--VSTDEMGDIIARY 358 I S+AL+L S + A + A+ E G T DL++ A VST E GD++ Sbjct: 302 MIGSVALMLEMSFGLEKEAKNLWAAMQAVFENGYSTSDLSKEGEANLVSTAEFGDLVCAE 361 Query: 359 VAE 361 +A+ Sbjct: 362 LAK 364 >UniRef50_D0DDG4 3-isopropylmalate dehydrogenase n=1 Tax=Citreicella sp. SE45 RepID=D0DDG4_9RHOB Length = 594 Score = 348 bits (893), Expect = 2e-94, Method: Composition-based stats. Identities = 129/325 (39%), Positives = 183/325 (56%), Gaps = 13/325 (4%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATV 62 K Y++A++PGDGIG +V A++VL A + T+ + HG+ +P + Sbjct: 2 KTYNLALIPGDGIGVDVTDAAMEVLGAA-AKGRFAFDTTSFPWSCEYYLEHGRMMPEDGI 60 Query: 63 EGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 E DA+ G+VG W PD G LLP+RK F ++N+RP +L G+E Sbjct: 61 ETLRGFDAIYLGAVG---WPATVPDSVSLHGLLLPIRKAFNQYANIRPHRLLAGVEG--- 114 Query: 123 LRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFES 182 + A GFDILC+RE T G Y G E A +T V+ R +ERI R FE Sbjct: 115 ---PLKAEGFDILCIRENTEGEYSGAGGRVHEGKGNEVAVETSVFTRAGVERILRFGFEQ 171 Query: 183 ARKRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFD 241 AR RR +TS+ K+N + S + W E+ E+A EYPDV ++HM+ID +++ P D Sbjct: 172 ARSRRGHLTSVTKSNAQKYSMVFWDEVTRELAAEYPDVTVSHMHIDAMAAKMVMAPQDLD 231 Query: 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFG--LYEPAGGSAPDIAGKNIANPI 299 V++ SNLFGDIL+D A I G +G SA++N ++EP GSAPDIAGKNIANPI Sbjct: 232 VVVASNLFGDILTDLGAAIQGGLGFAASANINPDRSAPSMFEPVHGSAPDIAGKNIANPI 291 Query: 300 AQILSLALLLRYSLDADDAACAIER 324 A I S+A +L + +A+ +A + Sbjct: 292 AAIWSVAQMLDHLGEAEVSAAVLSA 316 >UniRef50_C3MI61 3-isopropylmalate dehydrogenase n=13 Tax=Proteobacteria RepID=C3MI61_RHISN Length = 371 Score = 348 bits (893), Expect = 2e-94, Method: Composition-based stats. Identities = 124/370 (33%), Positives = 189/370 (51%), Gaps = 23/370 (6%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMR-ITTSHYDVGGAAIDNHGQPLPPA 60 + IAVLPGDGIG EVM L++++A + ++ G G LP + Sbjct: 5 NDTLTIAVLPGDGIGREVMPACLELVNAATTMAGAPALAFQTHNAGAQYYAESGDALPAS 64 Query: 61 TVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAF 120 T++ C ++DA+LFG++G W + E L LR LF+ +RP + + GL Sbjct: 65 TLDACRKSDAILFGAMG---WPDIRFPDGTEIIPQLDLRMELGLFAGVRPIRWFPGLPRV 121 Query: 121 CPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAF 180 D A D + VRE T G+++ + +G E+A+DT R +R+ AF Sbjct: 122 L---TDPRAEQIDFVLVREQTEGLFYARGRGE--IRNDEEAYDTMQITRSGTQRVTEFAF 176 Query: 181 ESARKRRHK-----VTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIK 235 + AR+R+ + VT +DKANV QS +R++ +E+A + D+ H Y+D + ++K Sbjct: 177 DIARQRKRRGKPGNVTCVDKANVFQSMAFFRKVFDEVADRHSDLTKDHAYVDALALNMVK 236 Query: 236 DPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNI 295 P FDVL+ N+FGDILSD A + G MGM PSA + ++ GL++PA G+APDIAGK Sbjct: 237 KPWTFDVLVTENMFGDILSDLAAGLIGGMGMAPSADIGDK-HGLFQPAHGTAPDIAGKGC 295 Query: 296 ANPIAQILSLALLLRYSLD------ADDAACAIERAINRALEEGIRTGDLARGAAAVSTD 349 ANP A LS A++L + DAA +E A+ L + + Sbjct: 296 ANPSAMFLSAAMMLDWLAAKFGQPTLADAARLMEGAVEHTLSTKLAIPM--EYGGNANCA 353 Query: 350 EMGDIIARYV 359 EM + + Sbjct: 354 EMTRSVISSL 363 >UniRef50_UPI000150AB37 dehydrogenase, isocitrate/isopropylmalate family protein n=1 Tax=Tetrahymena thermophila RepID=UPI000150AB37 Length = 636 Score = 347 bits (891), Expect = 3e-94, Method: Composition-based stats. Identities = 109/359 (30%), Positives = 174/359 (48%), Gaps = 30/359 (8%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPAT 61 +N+ + + PG GIGPE+ + A + + I H+++ I+ G + + Sbjct: 302 KQNHKVVLFPGHGIGPEISQAVCDIFAAAK----VPIDWEHHEIYTKPINEAGDLIKEES 357 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 + L G P + R + +RK LF+N+RP + G++ Sbjct: 358 LNAVINYKWGLKGPFATPIG-------KGYRSLNVTMRKKLNLFANVRPCRSLAGVKT-- 408 Query: 122 PLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFE 181 + D++ +RE T G Y G E + + ++ + E IAR AFE Sbjct: 409 ------PYSNVDLVTIRENTEGEYSG----LEHAVVPGVVENLKIISQPACENIARYAFE 458 Query: 182 SARKR-RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQ 239 ARK R KV + KA V++ L+ +I++EYP++E ID M+L K+P Sbjct: 459 FARKNNRKKVVACHKAGVMKKGDGLFINTCKKISSEYPEIEYTEEQIDTVCMKLSKNPEV 518 Query: 240 FDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPI 299 FDV++ NL+GDI+SD CA + G +G+ S +++ +YE G+APDIAG N ANP Sbjct: 519 FDVMVMPNLYGDIVSDLCAGLIGGLGLTASGNISHTC-AVYEAVHGTAPDIAGLNKANPT 577 Query: 300 AQILSLALLLRYSLDADDAACAIERAINRALEEG-IRTGDLARGAAAVSTDEMGDIIAR 357 A +LS ++L+ ++ AIE A+ + L EG TGDL G A +TD +I Sbjct: 578 ALLLSGVMMLK-AMGLQKEGFAIEEAVIKTLSEGKFLTGDL--GGKATTTDYTKAVIGH 633 >UniRef50_A5US63 Homoisocitrate dehydrogenase n=6 Tax=Chloroflexi (class) RepID=A5US63_ROSS1 Length = 362 Score = 346 bits (888), Expect = 8e-94, Method: Composition-based stats. Identities = 128/377 (33%), Positives = 187/377 (49%), Gaps = 40/377 (10%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 Y I V+PGDGIG EV+ A+ VL A + + D G G+ LP AT+ Sbjct: 5 PYTILVIPGDGIGREVIPAAVAVLRAT----GLPFHFENADAGWECFQRQGEALPSATLT 60 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 ADA+LFG+V P + R ++ LR+ L++N+RP + Sbjct: 61 AARAADAILFGAVASPGYP-----VAGYRSPIVRLRRELDLYANIRPVF-----DDLPEN 110 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 ++ D++ VRE T +Y G+ + + A V R RI R+A + A Sbjct: 111 GSNPRRRKVDLVVVRENTEDVYAGRERVEDDGAT---AIAERVITRRASARIMRVACDLA 167 Query: 184 RKRR----------HKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQ 232 R RR +VT + KANVL+ + L+R + E+A YPD+++ M +D +Q Sbjct: 168 RARRSARNGSDAPPGRVTVVHKANVLRETCGLFRSVALEVAQAYPDLQIDEMLVDTCALQ 227 Query: 233 LIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAG 292 L P +FDV++ +NLFGDILSD G +G+ PSA+L E+ L+EP G+APDIAG Sbjct: 228 LATRPERFDVIVTTNLFGDILSDVACAWGGGLGLAPSANLGER-HALFEPVHGAAPDIAG 286 Query: 293 KNIANPIAQILSLALLLRYSLDADDA---------ACAIERAINRALEEGIRTGDLARGA 343 K IANP+A I ALLL + A + I+RAI G T DL G Sbjct: 287 KGIANPLAAIGCTALLLDHLAGRAPADLASAMRGWSARIQRAIRHVRAAGPHTPDL--GG 344 Query: 344 AAVSTDEMGDIIARYVA 360 +AV+TD +++ + Sbjct: 345 SAVTTDITNAVLSHMLT 361 >UniRef50_B0ER68 Tartrate dehydrogenase, putative n=2 Tax=Entamoeba RepID=B0ER68_ENTDI Length = 370 Score = 346 bits (887), Expect = 1e-93, Method: Composition-based stats. Identities = 126/359 (35%), Positives = 199/359 (55%), Gaps = 21/359 (5%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 + I V+PGDGIG EVM++A K+ ++ + I + D G G+ +P ++ Sbjct: 10 QHKIIVIPGDGIGVEVMSEAEKMFQSLN----LPIQRDYVDWGIQHYLKTGKVVPIDYID 65 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 +Q DA+L GS+G P+ +P L+ +R+ F LRPAK + G+ PL Sbjct: 66 QVKQYDAILLGSLGDPRTLPDYVTLEP----LIQMRQQLDQFLCLRPAKHFPGIPT--PL 119 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 + DIL VRE + G Y + E A ++ V+ R +ER+ R AFE++ Sbjct: 120 KK----CEIDILVVRENSEGEYSNIGGIFKSGTPDEFAIESAVHTRRGLERVIRYAFEAS 175 Query: 184 RKRRHKVTSIDKANVLQSSI-LWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDV 242 RKRR+ VT K+N ++ + LW + IA EYPDV Y+D + +++K+PS+FDV Sbjct: 176 RKRRNHVTLATKSNAMKYGMVLWDSVFEAIAMEYPDVTAEKYYMDALSAEIVKNPSKFDV 235 Query: 243 LLCSNLFGDILSDECAMITGSMGMLPSASLNEQG--FGLYEPAGGSAPDIAGKNIANPIA 300 ++ SNLF DI+SD + GSMG+ PSA++N + L+EP GSA DIAGK I +PI Sbjct: 236 IVGSNLFCDIISDLTVTVAGSMGIAPSANINPERTFPSLFEPVHGSALDIAGKGICDPIG 295 Query: 301 QILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYV 359 + + +++L + L + + IE AI ++ + I T D+ +T+E+G+ IA Y+ Sbjct: 296 TMRASSMMLEF-LGYSEESVLIEEAIQSSILQKITTIDI---GGTKTTNEVGNFIADYI 350 >UniRef50_B9KYU3 Isocitrate dehydrogenase (NADP) n=3 Tax=Bacteria RepID=B9KYU3_THERP Length = 496 Score = 345 bits (886), Expect = 1e-93, Method: Composition-based stats. Identities = 117/357 (32%), Positives = 179/357 (50%), Gaps = 27/357 (7%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNH-GQPLPPATVEGC 65 + ++PGDGIGPE++ A ++++AV I G + +P T+E Sbjct: 23 VTLIPGDGIGPEIVESACRLIEAV----GAPIEWEVRRAGASVFREGIASGVPDDTIESI 78 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 ++ VL G + P E+ A + LRK F+ F+N+RP + + Sbjct: 79 KRTRVVLKGPLETPVGYG-------EKSANVTLRKLFEAFANVRPVRELPSVPTPY---- 127 Query: 126 DIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARK 185 D++ VRE +Y + RE G ++ E+I R AFE AR Sbjct: 128 --RGRNIDLVVVRENIEDLYAAI-EYRETPG---VTIAHKLISYKGSEKIIRFAFELARA 181 Query: 186 -RRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVL 243 R KVT K+N+L+ + ++ I EIA+EYPD+E H+ IDN QL+K P QF+V+ Sbjct: 182 EGRKKVTCATKSNILKLTEGWFQHIFEEIASEYPDIEANHLIIDNCAHQLVKAPEQFEVI 241 Query: 244 LCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQIL 303 + +NL GDI+SD + + G +G S + + ++EP G+AP AGKN+ NP A IL Sbjct: 242 VTTNLNGDIISDLASGLVGGLGFAASGNYGHE-VAIFEPVHGTAPKYAGKNVINPTAMIL 300 Query: 304 SLALLLRYSLDADDAACAIERAINRALEEGI-RTGDLARGAAAVSTDEMGDIIARYV 359 + ++LRY +D + A IE+A+ LEEG T D+ AVST D I + Sbjct: 301 TAVMMLRY-IDEFETAETIEQALIVTLEEGKALTRDVVGDERAVSTTAFTDAIIANL 356 >UniRef50_P34738 3-isopropylmalate dehydrogenase n=8 Tax=cellular organisms RepID=LEU3_NEUCR Length = 368 Score = 345 bits (885), Expect = 2e-93, Method: Composition-based stats. Identities = 161/371 (43%), Positives = 228/371 (61%), Gaps = 22/371 (5%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAV--RNRFAMRITTSHYDVGGAAIDNHGQPLPPAT 61 ++I V GD GPEV+ +A+KVL A+ + A + ++ +GGA+ID H PL Sbjct: 3 THNIVVFGGDHCGPEVVLEAIKVLKAIETNSPSAGKFNLQNHLLGGASIDKHNDPLTDEA 62 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKL-YQGLEAF 120 + + ADAVL G++GGP+W +PE+G LL LRK + NLRP + L Sbjct: 63 LNAAKAADAVLLGAIGGPEW-GTSSTVRPEQG-LLKLRKELGTYGNLRPCNFASESLVDS 120 Query: 121 CPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIA- 179 PL+A++ G D + VRELTGGIYFG +GSG A DTE Y R EI RIAR+A Sbjct: 121 SPLKAEVC-RGTDFIVVRELTGGIYFGDRTEDDGSG---YACDTEPYSRAEIVRIARLAG 176 Query: 180 -FESARKRRHKVTSIDKANVLQSSILWREIVNEI-ATEYPDVELAHMYIDNATMQLIKDP 237 A+ KV S+DKANVL +S LWR+ V ++ + E+P ++L H ID+A M L+K+P Sbjct: 177 FLALAKNPPAKVWSLDKANVLATSRLWRKTVTDVISKEFPQLQLEHQLIDSAAMLLVKNP 236 Query: 238 SQFD-VLLCSNLFGDILSDECAMITGSMGMLPSASLNE------QGFGLYEPAGGSAPDI 290 + V++ SNLFGDI+SDE ++I GS+G+LPSASL + G+YEP GSAPDI Sbjct: 237 RALNGVVITSNLFGDIISDEASVIPGSIGLLPSASLGGIPDGKGKCNGIYEPIHGSAPDI 296 Query: 291 AGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDE 350 +GK I NP+ ILS+A++LRYSL+ A A+E A+ A++ G +T DL A +T + Sbjct: 297 SGKGIVNPVGTILSVAMMLRYSLNLPKEADAVEAAVKAAIDNGTKTKDLGGNA---TTSD 353 Query: 351 MGDIIARYVAE 361 MG+ + + + Sbjct: 354 MGNAVVAELEK 364 >UniRef50_UPI0001C310FF Tartrate decarboxylase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C310FF Length = 370 Score = 345 bits (885), Expect = 2e-93, Method: Composition-based stats. Identities = 126/354 (35%), Positives = 188/354 (53%), Gaps = 18/354 (5%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 ++ +LPGDG+GPEVM +A K LDA+ + I + G A HG +P ++ Sbjct: 2 NVVLLPGDGVGPEVMAEARKALDAL----ELGIAWTDVPWGSAWWAEHGTMMPADAIDVL 57 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 DA+L G+VG P PD + G +L +R+ L+ N+RPA+L +G+ A Sbjct: 58 RGHDAILMGAVGDP----AVPDDEALWGLILKIRQELDLWVNVRPARLLEGIPGPL---A 110 Query: 126 DIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARK 185 A + D++ VRE + G Y G ++ A ++ V+ R ER+ R AF A Sbjct: 111 GRAPHDVDMVFVRENSEGEYAGVGGRVHRGFGHDVAIESSVFTRRGCERVIRYAFGMASA 170 Query: 186 RRHKVTSIDKANVLQSSI-LWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLL 244 R+ + + K+N + W EIV E+ E+P V + M +D + +LI+DP DV++ Sbjct: 171 RKGVLVNATKSNASRFGFPFWDEIVAEVGAEFPGVVVDRMLVDALSARLIRDPGSVDVVV 230 Query: 245 CSNLFGDILSDECAMITGSMGMLPSASLNEQG--FGLYEPAGGSAPDIAGKNIANPIAQI 302 SNLFGDIL+D A + G MGM SA+L+ G L+EP GSAPDIAG+ IANP+ I Sbjct: 231 ASNLFGDILTDIAAALQGGMGMAASANLSPGGGVPALFEPVHGSAPDIAGRGIANPVGAI 290 Query: 303 LSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIA 356 S AL+L L A + + + A+ G RT D+ +T E+GD + Sbjct: 291 WSAALMLE-QLGAGEGSRRLMDALETVCRRGPRTRDV---GGTATTAEVGDAVV 340 >UniRef50_Q0D0R7 Isocitrate dehydrogenase subunit 2, mitochondrial n=17 Tax=Dikarya RepID=Q0D0R7_ASPTN Length = 385 Score = 345 bits (885), Expect = 2e-93, Method: Composition-based stats. Identities = 108/362 (29%), Positives = 172/362 (47%), Gaps = 36/362 (9%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHG-QPLPPATV 62 Y + ++ GDGIGPE+ + A I DV I G +P + Sbjct: 54 KYTVTLIEGDGIGPEISQSVKDIFSAANA----PIKWEPVDV--TPILKDGKTAIPDDAI 107 Query: 63 EGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 E + L G + P + L LR+ F LF+N+RP + G + Sbjct: 108 ESVRRNYVALKGPLATPVG-------KGHVSLNLTLRRTFNLFANVRPCRSIAGYKT--- 157 Query: 123 LRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFES 182 + D + +RE T G Y G E ++ + ER+ R AF+ Sbjct: 158 -----PYDNVDTVLIRENTEGEYSG----IEHVVVDGVVQSIKLITKEASERVLRFAFQY 208 Query: 183 ARK-RRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQF 240 AR + KV + KA +++ S L+ EIA ++PDVE +DN+ ++++ DP+ + Sbjct: 209 ARSINKKKVRVVHKATIMKMSDGLFLNTAREIAKDFPDVEFDAELLDNSCLKIVTDPTPY 268 Query: 241 D--VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANP 298 + VL+ NL+GDILSD CA + G +G+ PS ++ ++ ++E GSAPDIAGK +ANP Sbjct: 269 NDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDEC-SIFEAVHGSAPDIAGKGLANP 327 Query: 299 IAQILSLALLLRYSLDADDAACAIERAINRALEEGI-RTGDLARGAAAVSTDEMGDIIAR 357 A +LS ++L++ + + A I++AI L EG TGDL T E + I + Sbjct: 328 TALLLSSIMMLQH-MGLHEHAGRIQKAIFDTLAEGKALTGDL---GGKAKTSEYAEAIMK 383 Query: 358 YV 359 + Sbjct: 384 KL 385 >UniRef50_A5CDH3 Isocitrate dehydrogenase, NADP-dependent n=7 Tax=Rickettsiales RepID=A5CDH3_ORITB Length = 519 Score = 344 bits (884), Expect = 2e-93, Method: Composition-based stats. Identities = 103/367 (28%), Positives = 178/367 (48%), Gaps = 32/367 (8%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQP-LPP 59 M + + GDGIGPE+M + VL + + ++G + + + Sbjct: 1 MKNVIPVTIAYGDGIGPEIMEAVVYVLKEAA----VPLRLETIEIGEKLYNKYYTYGITE 56 Query: 60 ATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRP-AKLYQGLE 118 T + A+L G V P+ + + LRK L++N+RP + + Sbjct: 57 DTWSQIFRTKALLKGPVTTPQGGG-------YKSLNVTLRKTLGLYANVRPSCSYFPFVN 109 Query: 119 AFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARI 178 P D++ +RE +Y G + + YE ++ R E+I R Sbjct: 110 TSAP--------EIDVVIIRENEEDLYAGI-EYHHTADTYE---SVKLISRSGSEKIIRF 157 Query: 179 AFESA-RKRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKD 236 AFE A + R ++ K N+++ + ++ + NEIA++Y ++++ H ID + +LI Sbjct: 158 AFEYALKNNRKTISCFSKDNIMKFTDGIFHKTFNEIASQYSNIQVDHYLIDIGSARLISS 217 Query: 237 PSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIA 296 P +FDV++ SNL+GDILSD A I+GS+G+ SA++ + + ++E GSAPDIAG+NIA Sbjct: 218 PQKFDVIVTSNLYGDILSDIAAKISGSIGLAGSANIGKD-YAMFEAVHGSAPDIAGQNIA 276 Query: 297 NPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLAR---GAAAVSTDEMGD 353 NP + + ++L + L + A IE A+ + +E+GI T D+ + V T E Sbjct: 277 NPSGLLNAAIMMLVH-LGLTEHAAKIENALKKTIEDGIHTADIYNPSISSTKVGTKEFAQ 335 Query: 354 IIARYVA 360 I + Sbjct: 336 AIINNLE 342 >UniRef50_UPI0001B4F4BD putative isocitrate/isopropylmalate dehydrogenase / tartrate dehydrogenase ttuC n=1 Tax=Streptomyces hygroscopicus ATCC 53653 RepID=UPI0001B4F4BD Length = 357 Score = 344 bits (884), Expect = 2e-93, Method: Composition-based stats. Identities = 128/364 (35%), Positives = 190/364 (52%), Gaps = 17/364 (4%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPAT 61 +K +AV+PGDGIGPEV+ + L A R+ + +D GG G +PP Sbjct: 5 TKVVRLAVIPGDGIGPEVVAATVPALRAALEADGHRLDVTSFDWGGERYLRQGAAMPPDA 64 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 + ++ DAVLFG+VG P P+ + G ++ LR+ L NLRP + + G+ Sbjct: 65 ADLVKKTDAVLFGAVGRPD----VPEHELVWGLIIGLRQQLDLAVNLRPVRAFPGVPTKV 120 Query: 122 PLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFE 181 +G D++ VRE T G Y G ++ + V+ R IER A AF Sbjct: 121 -----RDTDGVDLVIVRENTEGEYVGAGGVAHAGSGHDLGIEVAVHSRRAIERAAHQAFA 175 Query: 182 SARKRRHKVTSIDKANVLQSSI-LWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQF 240 A +R ++ + K+N ++ LW +V E+ +YP VEL + +D ++I+ P Sbjct: 176 LAGRRSGRLCLVTKSNAMRYGYPLWDRVVREVGEQYPGVELETVLVDAMAARMIQAPRSL 235 Query: 241 DVLLCSNLFGDILSDECAMITGSMGMLPSASL--NEQGFGLYEPAGGSAPDIAGKNIANP 298 DVLL SNLFGDILSD A++ G MGM PSA++ + + G+YEP GSAPDIAGK +ANP Sbjct: 236 DVLLASNLFGDILSDLAAVLAGGMGMAPSANVLPDAEVPGIYEPVHGSAPDIAGKGVANP 295 Query: 299 IAQILSLALLLRYSLDADDAACAIERAINRALEE-GIRTGDLARGAAAVSTDEMGDIIAR 357 +A +LS A+LL L DAA + A+ L + T DL A +T ++ + Sbjct: 296 VACLLSGAMLLE-DLGHTDAARRVRDAVADTLRDTRHHTADLGGNA---TTADVASAVLH 351 Query: 358 YVAE 361 + Sbjct: 352 TMES 355 >UniRef50_P33197 Isocitrate dehydrogenase [NADP] n=10 Tax=Bacteria RepID=IDH_THET8 Length = 496 Score = 343 bits (881), Expect = 5e-93, Method: Composition-based stats. Identities = 117/359 (32%), Positives = 181/359 (50%), Gaps = 27/359 (7%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNH-GQPLPPATVEGC 65 I V+PGDGIGPE + LKVL+A + A + + G + +P T+E Sbjct: 22 ITVIPGDGIGPECVEATLKVLEAAKAPLAYEVR----EAGASVFRRGIASGVPQETIESI 77 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 + VL G + P E+ A + LRK F+ ++N+RP + + + Sbjct: 78 RKTRVVLKGPLETPVGYG-------EKSANVTLRKLFETYANVRPVREFPNVPTPY---- 126 Query: 126 DIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARK 185 A G D++ VRE +Y G + S A ++ E+I R AFE AR Sbjct: 127 --AGRGIDLVVVRENVEDLYAGIEHMQTPS----VAQTLKLISWKGSEKIVRFAFELARA 180 Query: 186 -RRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVL 243 R KV K+N+++ + + ++A EYPD+E H+ +DNA QL+K P QF+V+ Sbjct: 181 EGRKKVHCATKSNIMKLAEGTLKRAFEQVAQEYPDIEAVHIIVDNAAHQLVKRPEQFEVI 240 Query: 244 LCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQIL 303 + +N+ GDILSD + + G +G PSA++ + ++E GSAP AGKN+ NP A +L Sbjct: 241 VTTNMNGDILSDLTSGLIGGLGFAPSANIGNE-VAIFEAVHGSAPKYAGKNVINPTAVLL 299 Query: 304 SLALLLRYSLDADDAACAIERAINRALEEG-IRTGDLARGAAAVSTDEMGDIIARYVAE 361 S ++LRY L+ A IE A+ LEEG + TGD+ T E + I + + + Sbjct: 300 SAVMMLRY-LEEFATADLIENALLYTLEEGRVLTGDVVGYDRGAKTTEYTEAIIQNLGK 357 >UniRef50_Q0W5L4 3-isopropylmalate dehydrogenase n=14 Tax=root RepID=Q0W5L4_UNCMA Length = 380 Score = 343 bits (880), Expect = 6e-93, Method: Composition-based stats. Identities = 125/384 (32%), Positives = 191/384 (49%), Gaps = 36/384 (9%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 +Y + V+ GDGIGPEV+ + KV+ A + + + G+ + ++++ Sbjct: 3 SYKVPVIAGDGIGPEVIAEGRKVIAAAQEVYNFDVEWIDMPFSADHYVKTGETISESSLK 62 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 + A+ GS+G + E+G LL +R ++ + NLRP KL +G+E PL Sbjct: 63 ELSKYRAIFLGSIGD---DRKVKPGVLEKGILLTMRFYYDQYVNLRPVKLMEGVET--PL 117 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGRE-----------------------GSGQYEK 160 + AA+ D VRE T Y G + + E Sbjct: 118 KGKTAAD-IDFYVVRENTEDFYVGIGGRSKKGTSKQELEVIRQMYSVKFGLDVETDSDEI 176 Query: 161 AFDTEVYHRFEIERIARIAFESARKRRHK-VTSIDKANVLQS-SILWREIVNEIATEYPD 218 A+ V + +RI +F+ A R K ++S+DKANVL WRE+ + A +YPD Sbjct: 177 AYQLGVVSKEGAKRIIEYSFDLANSRPKKHLSSVDKANVLTDIYGFWREVFTDTAAKYPD 236 Query: 219 VELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFG 278 V+ Y+D TM +K+P FDV++ N+FGDI++D AMI G +G+ P ++N +G Sbjct: 237 VKTDFNYVDAVTMWFVKNPEFFDVVVSPNMFGDIITDLGAMIQGGLGLAPGGNINPEGTS 296 Query: 279 LYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEE-GIRTG 337 ++EP GGSAP G N NPIA I + A+LL + L AA I AI + L+E IRT Sbjct: 297 MFEPMGGSAPKYKGLNKVNPIATIWAGAMLLEH-LGEKQAAAGIVDAIEQNLKEKKIRTY 355 Query: 338 DLARGAAAVSTDEMGDIIARYVAE 361 DL + T ++G IAR V + Sbjct: 356 DL---GGSAGTSDVGTDIARIVKQ 376 >UniRef50_A5UMS5 3-isopropylmalate dehydrogenase, LeuB n=8 Tax=Euryarchaeota RepID=A5UMS5_METS3 Length = 336 Score = 340 bits (873), Expect = 5e-92, Method: Composition-based stats. Identities = 130/355 (36%), Positives = 189/355 (53%), Gaps = 35/355 (9%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 Y IAV+PGDGIG EVM + VLD + + + G + HG PLP T++ Sbjct: 10 KYQIAVIPGDGIGKEVMEATISVLDEL----DVDFDYIYGIAGDECNEEHGTPLPQETID 65 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 +DA LFG+ G + ++ +R+ K+F+NLRP K Y ++ Sbjct: 66 IVRDSDACLFGAAG-----------ETAADVIVKIRQEMKMFANLRPVKSYPNTKSLF-- 112 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 D + VRE T G+Y + G A V R ERI AF+ A Sbjct: 113 ------ENVDFMIVRENTEGLYIADQEEETEDG----AIAKRVITREAEERIIDYAFQYA 162 Query: 184 R-KRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFD 241 + R KVT++ KANVL+ + L+++I E+ +YPD++ Y+D M L+ P +F Sbjct: 163 KDNNRTKVTAVHKANVLKKTDGLFKKIFYEVGEKYPDIDTEDFYVDATAMYLVTQPQEFQ 222 Query: 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQ 301 V++ +NLFGDILSDE A + G +G++PSA++ G L+EP GSAPDIAG+ ANPIA Sbjct: 223 VVVTTNLFGDILSDEGAGLVGGLGLIPSANIGADG-ALFEPVHGSAPDIAGQQKANPIAM 281 Query: 302 ILSLALLLRYSLDADDAACAIERAINRALEEG-IRTGDLARGAAAVSTDEMGDII 355 +LS ++LRY L +DAA + AI + L EG TGDL + +T E+ + Sbjct: 282 MLSAIMMLRY-LGENDAADKFDAAILKVLSEGKTLTGDL---GGSATTMEVAQAV 332 >UniRef50_Q47SB4 3-isopropylmalate dehydrogenase n=15 Tax=cellular organisms RepID=LEU3_THEFY Length = 354 Score = 339 bits (871), Expect = 8e-92, Method: Composition-based stats. Identities = 145/364 (39%), Positives = 208/364 (57%), Gaps = 18/364 (4%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPAT 61 ++ +AV+PGDGIGPEV+ + LKVL AV R + + T+ Y++G G+ LP A Sbjct: 3 ARTVKLAVIPGDGIGPEVVAEGLKVLSAVAPRHGLTLDTTEYELGAQRWHATGEVLPDAV 62 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 E Q DA+L G+VG P P ERG LL LR +F + NLRP +LY G+ Sbjct: 63 EEELRQHDAILLGAVGDP----TVPSGVLERGLLLRLRFNFSHYVNLRPVRLYPGVTTPL 118 Query: 122 PLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFE 181 A +A D+L VRE T G Y G +E A V R +ER+ R AF Sbjct: 119 ---AGVAPEDIDMLVVREGTEGPYAGMGGVLRKGTPHEIATQDSVNTRLGVERVVRYAFA 175 Query: 182 SARKRR-HKVTSIDKANVLQSSI-LWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQ 239 A +R HK+T + K NVL + LW+ +V E+ EYP VE+ ++++D ATM + P + Sbjct: 176 KAAERPCHKLTLVHKDNVLTYAGELWQRVVREVGAEYPQVEVDYLHVDAATMFFVTQPRR 235 Query: 240 FDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQG--FGLYEPAGGSAPDIAGKNIAN 297 FDV++ NLFGDI++D A + G +G+ S ++N +G ++EP GSAPDIAG+ A+ Sbjct: 236 FDVVVTDNLFGDIITDLGAAVAGGIGLAASGNINPEGDFPSMFEPVHGSAPDIAGQGKAD 295 Query: 298 PIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIAR 357 P A ILS++L+L + L DAA I++A+ L+E A+ ST ++GD IA+ Sbjct: 296 PTATILSVSLMLEH-LGYADAAAQIDQAVAEDLQER------AKNGGVRSTTQIGDDIAQ 348 Query: 358 YVAE 361 VAE Sbjct: 349 RVAE 352 >UniRef50_A6WAX5 3-isopropylmalate dehydrogenase n=20 Tax=Bacteria RepID=A6WAX5_KINRD Length = 377 Score = 337 bits (866), Expect = 3e-91, Method: Composition-based stats. Identities = 129/369 (34%), Positives = 198/369 (53%), Gaps = 28/369 (7%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAM-RITTSHYDVGGAAIDNHGQPLPPA 60 SK Y +AVL GDGIGPE++ ++K+LDA I + +G +AID +G+ P Sbjct: 21 SKQYSLAVLHGDGIGPEIVPASVKILDAAVAAAGATPIAWTELPLGRSAIDEYGEHTPTK 80 Query: 61 TVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAF 120 T++ ++ D L G + P + + +RKHF LF+N+RPAK ++G Sbjct: 81 TLDALDEVDGWLLGPHDSAAY---PEPYRSQLNPSGTIRKHFGLFANIRPAKAFRG---- 133 Query: 121 CPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQY----EKAFDTEVYHRFEIERIA 176 + G D++ VRE T G Y + G+G+ + A + R ERIA Sbjct: 134 ----GNAIVEGTDLVIVRENTEGFYADRN-TFAGTGEMMPTPDVAIMHGIITRAATERIA 188 Query: 177 RIAFESARKRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIK 235 AF+ AR R +VT + KANVL+ ++ L+R++ E+ +YPDV + +ID AT+ L++ Sbjct: 189 HEAFQLARTRDKRVTIVHKANVLKMTTGLFRDVCREVGKQYPDVAINDFHIDAATVHLVR 248 Query: 236 DPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNI 295 +FDV++ N+FGDILSD + GS+G+ PS + + + + + GSAPDIAG++I Sbjct: 249 RADKFDVIVTENMFGDILSDLAGEVAGSLGIAPSIN-SSATHAMAQASHGSAPDIAGRDI 307 Query: 296 ANPIAQILSLALLLRYSLDADD------AACAIERAINRALEEGIRTGDLARGAAAVSTD 349 ANPIA ILS A+LLR+ D AA +E A++ + EG T D+ S Sbjct: 308 ANPIAMILSSAMLLRWLAAKFDDEKIARAADIVEAAVDLTVAEGATTPDM---GGTSSCS 364 Query: 350 EMGDIIARY 358 D + Sbjct: 365 GFADAVVAA 373 >UniRef50_P40495 Homoisocitrate dehydrogenase, mitochondrial n=66 Tax=Dikarya RepID=LYS12_YEAST Length = 371 Score = 337 bits (865), Expect = 3e-91, Method: Composition-based stats. Identities = 120/370 (32%), Positives = 185/370 (50%), Gaps = 33/370 (8%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATV 62 K+ I ++PGDGIG EV+ +VL+ + ++ + G G+ LP TV Sbjct: 22 KSLTIGLIPGDGIGKEVIPAGKQVLENLNSKHGLSFNFIDLYAGFQTFQETGKALPDETV 81 Query: 63 EGCEQ-ADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 + ++ LFG+V P + ++ LR+ LF+N+RP K +G Sbjct: 82 KVLKEQCQGALFGAVQSP-----TTKVEGYSSPIVALRREMGLFANVRPVKSVEG----- 131 Query: 122 PLRADIAANGFDILCVRELTGGIYFGQPKG-REGSGQYEKAFDTEVYHRFEIERIARIAF 180 D++ VRE T +Y K + + A T+ RIA IA Sbjct: 132 -----EKGKPIDMVIVRENTEDLYIKIEKTYIDKATGTRVADATKRISEIATRRIATIAL 186 Query: 181 ESARKR-----RHKVTSIDKANVL-QSSILWREIVNEI----ATEYPDVELAHMYIDNAT 230 + A KR + +T K+NVL QS L+REI E+ +Y ++ +D+ Sbjct: 187 DIALKRLQTRGQATLTVTHKSNVLSQSDGLFREICKEVYESNKDKYGQIKYNEQIVDSMV 246 Query: 231 MQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDI 290 +L ++P FDV++ NL+GDILSD A + GS+G++PSA++ + + EP GSAPDI Sbjct: 247 YRLFREPQCFDVIVAPNLYGDILSDGAAALVGSLGVVPSANVGPE-IVIGEPCHGSAPDI 305 Query: 291 AGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEG-IRTGDLARGAAAVSTD 349 AGK IANPIA I S AL+L + L ++AA I +A++ L EG I+T DL ST Sbjct: 306 AGKGIANPIATIRSTALMLEF-LGHNEAAQDIYKAVDANLREGSIKTPDL---GGKASTQ 361 Query: 350 EMGDIIARYV 359 ++ D + + Sbjct: 362 QVVDDVLSRL 371 >UniRef50_D0RN50 Threo-isocitrate dehydrogenase [NAD] n=1 Tax=alpha proteobacterium HIMB114 RepID=D0RN50_9RICK Length = 357 Score = 337 bits (864), Expect = 4e-91, Method: Composition-based stats. Identities = 118/372 (31%), Positives = 189/372 (50%), Gaps = 26/372 (6%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPA 60 MS N VL GDGIGPE+ ++ VL A + +++ + ++G A++ H Sbjct: 1 MS-NLKFLVLEGDGIGPEIAKASVDVLQAALKLYDLKVNLVYEEIGFASLKKHKTTFRSE 59 Query: 61 TVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAF 120 ++ E+ D ++ G+ + PP ++ +RK+F L++N+RPAK G Sbjct: 60 VLKIAEKCDGMILGTCSHNDY---PPTEEGGLNPSGVIRKYFDLYANVRPAKNRLGKLER 116 Query: 121 CPLRADIAANGFDILCVRELTGGIYFGQPKGREGSG---QYEKAFDTEVYHRFEIERIAR 177 P+ G D L +RE T G Y + + + A R RIA Sbjct: 117 FPM-------GIDCLVMRENTEGFYSDRNMFKGVGELMPTPDVAISIRNITRKGSTRIAE 169 Query: 178 IAFESARKRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKD 236 I F+ A +RR K+ +I KANVL+ S L+ E +++ +YP+VE +D+ + LI+D Sbjct: 170 IGFKYAMERRKKLVAIHKANVLRYSDGLFLECARQVSKKYPEVEYKEQIVDSMSAMLIRD 229 Query: 237 PSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIA 296 PS FDV+L +NLFGD LSD + I G +G+ S + E + + + GSAPDIAGKNIA Sbjct: 230 PSVFDVILATNLFGDNLSDAASEIAGGLGLAESINAGEN-YCIAQAQHGSAPDIAGKNIA 288 Query: 297 NPIAQILSLALLLRYSL------DADDAACAIERAINRA-LEEGIRTGDLARGAAAVSTD 349 NP++ I S A++L + + A IE AI++ + RT D+ +ST Sbjct: 289 NPVSLIGSTAMMLDWLGKKNNNQQLKEIAQMIEDAIDKTIINPKTRTSDI---GGNLSTT 345 Query: 350 EMGDIIARYVAE 361 + D++ + + Sbjct: 346 DFTDVLISNLKK 357 >UniRef50_O59930 3-isopropylmalate dehydrogenase n=12 Tax=cellular organisms RepID=LEU3_PHACH Length = 380 Score = 337 bits (864), Expect = 5e-91, Method: Composition-based stats. Identities = 163/383 (42%), Positives = 226/383 (59%), Gaps = 29/383 (7%) Query: 1 MSK-NYHIAVLPGDGIGPEVMTQALKVLDAV-RNRFAMRITTSHYDVGGAAIDNHGQPLP 58 MSK + I +LPGDGIGPEV+ +A +VL+ V + + I +D GG +ID HG+PL Sbjct: 1 MSKRTFKIVILPGDGIGPEVVAEATRVLEVVSASSSDVEIKLETHDFGGCSIDKHGEPLT 60 Query: 59 PATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKL-YQGL 117 AT+E C+ ADA+L G++GGPKW + +PE+ ALL LRK L++N+RPA L Sbjct: 61 AATLEACKLADAILLGAIGGPKW-GVNSKVRPEQ-ALLALRKALGLYANIRPANFASDSL 118 Query: 118 EAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIAR 177 A+ PL+ + A G DI+ +REL GG YFG+ K Q + A+DT +Y E++RI R Sbjct: 119 LAYSPLKPSV-ARGVDIIVIRELIGGAYFGERKELGARAQEDAAWDTMIYSVPEVQRITR 177 Query: 178 IAFESARKRRH-KVTSIDKANVLQSSILWREIVNE-IATEYPDVELAHMYIDNATMQLIK 235 + A V SIDKANVL SS LWR++ E I E+P ++L H +D+A+M ++ Sbjct: 178 SRRQVASPDPPLPVHSIDKANVLASSRLWRKVATETIQNEFPQLKLDHHLVDSASMLIVA 237 Query: 236 DPSQFD-VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFG------------LYEP 282 +P + + V+L NLFGDILSDE ++I GS+G+LPSASL + +YEP Sbjct: 238 NPKKLNGVILTENLFGDILSDESSVIPGSLGLLPSASLAARPLWPNTAHRRSSPRRVYEP 297 Query: 283 AGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRA-----LEEGIRTG 337 GSAPDIAG+ IANPI ILS A+L A AIE A+ A EG+RT Sbjct: 298 IHGSAPDIAGQGIANPIGTILSAAMLCGTRSVWRSPAKAIEAAVEGARRQGDRREGLRTA 357 Query: 338 DLARGAAAVSTDEMGDIIARYVA 360 DL + T ++G + + Sbjct: 358 DL---GGSSKTKDIGHKVVEILK 377 >UniRef50_D0LNY3 3-isopropylmalate dehydrogenase n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LNY3_HALO1 Length = 400 Score = 336 bits (862), Expect = 8e-91, Method: Composition-based stats. Identities = 118/363 (32%), Positives = 172/363 (47%), Gaps = 24/363 (6%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHG-QPLPPATV 62 +Y + +LPGDGIGPEVM QA +L+AV +R GG HG + P Sbjct: 9 SYQVVLLPGDGIGPEVMAQARDLLEAVAEPSGVRFELDEIPCGGRFYLEHGARDWPEDAE 68 Query: 63 EGCEQADAVLFGSVGGPKWEHLPP-----DQQPERGALLPLRKHFKLFSNLRPAKLYQGL 117 C AD +L G+VG P + P A++ R L++N+RP KL G+ Sbjct: 69 ARCRGADVILLGAVGWPSPDGPGPVMMGNGNMAGHSAVIGNRVDLDLYANVRPVKLLPGV 128 Query: 118 EA--FCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERI 175 + D++ +RE T G+Y G G A DT + R ERI Sbjct: 129 AHRISGTRQQVWRPEHVDMVILRENTEGLYAGMGGQLRVGGSASVATDTRLITRRGCERI 188 Query: 176 ARIAFESARKRR--------HKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYID 227 R AFE +R +VT I K NVL+ L+ E+ E+A+EYPD+ +D Sbjct: 189 IRRAFELCEQRGRGAPGDGVKRVTGIVKHNVLEGCKLFAEVFAEVASEYPDIANELAIVD 248 Query: 228 NATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSA 287 T L+ P +DV + +NLFGDI++D +++ G MGM ++ ++ ++EP GSA Sbjct: 249 AFTQWLVTQPEHYDVCVTTNLFGDIVTDLASVLQGGMGMAVGCNVGDE-HAMFEPIHGSA 307 Query: 288 PDIAGKNIANPIAQILSLALLLRYSLD------ADDAACAIERAINRALEEG-IRTGDLA 340 P +AGK+ ANP+A +L+ L + A A+ERA+ E G T DL Sbjct: 308 PPLAGKDEANPMAMLLATGEALAWLGQRHDDPRLRAIAHAVERAVATVAERGAPLTVDLV 367 Query: 341 RGA 343 Sbjct: 368 GAE 370 >UniRef50_Q1RJU4 Isocitrate dehydrogenase [NADP] n=62 Tax=cellular organisms RepID=IDH_RICBR Length = 483 Score = 335 bits (860), Expect = 1e-90, Method: Composition-based stats. Identities = 110/369 (29%), Positives = 179/369 (48%), Gaps = 32/369 (8%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNH-GQPLPP 59 M++ I + GDGIGPE+M L +L R I +VG H + Sbjct: 1 MAEFTPITIAYGDGIGPEIMEAVLYILRKAEAR----IRLETIEVGEKLYVKHYSSGISE 56 Query: 60 ATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRP-AKLYQGLE 118 + E E+ +L + P+ + + +RK +LF+N+RP Y + Sbjct: 57 QSWESIERTGVILKAPITTPQGGG-------YKSLNVTIRKTLQLFANIRPSVSFYPFTK 109 Query: 119 AFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARI 178 P ++ +RE +Y G + R+ YE ++ R E+I R Sbjct: 110 TLHP--------NLNLTIIRENEEDLYAGI-EYRQTHNMYE---SVKLISRTGCEKIIRY 157 Query: 179 AFESA-RKRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKD 236 AFE A + R KVT + K N+++ S ++ ++ NEIA EYP + H ID T +L Sbjct: 158 AFEYAVKNNRKKVTCLSKDNIMKFSDGIFHKVFNEIAKEYPQINNEHYIIDIGTARLATK 217 Query: 237 PSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIA 296 P FDV++ SNL+GDI+SD A I+GS+G+ SA++ E + ++E GSAPDIAG++IA Sbjct: 218 PEIFDVIVTSNLYGDIISDVAAEISGSVGLAGSANIGEH-YAMFEAVHGSAPDIAGQDIA 276 Query: 297 NPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLAR---GAAAVSTDEMGD 353 NP + + ++L + + D A IE A + +E+G+ T D+ V T E + Sbjct: 277 NPSGLLNAAIMMLVH-IGQGDIATLIENAWKKTIEDGMHTADIYNKDHSTKKVGTKEFAE 335 Query: 354 IIARYVAEG 362 + + + + Sbjct: 336 EVVKRLGQK 344 >UniRef50_A8TPC9 3-isopropylmalate dehydrogenase n=3 Tax=Alphaproteobacteria RepID=A8TPC9_9PROT Length = 371 Score = 335 bits (860), Expect = 1e-90, Method: Composition-based stats. Identities = 129/359 (35%), Positives = 177/359 (49%), Gaps = 22/359 (6%) Query: 5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEG 64 Y IAV+PGDGIGPEV ++VL + I YD G G P AT Sbjct: 13 YRIAVVPGDGIGPEVSAATVRVLTQALG-TSFPIEFRDYDAGAECFRRTGTAFPEATQVA 71 Query: 65 CEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 C QA AVL G+ G P P + + + +R L++N+RP +L +G + Sbjct: 72 CRQAHAVLHGAAGLPDV-LFPDGTEAGQDFSMKIRAALDLYANVRPIRLMEGAPRRLVGK 130 Query: 125 ADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESAR 184 + VRE T G+Y + G GQ A DT V R +ERI R A E AR Sbjct: 131 G---PDDIRFTIVRENTEGLYAARGGGNIIRGQ--IATDTLVMTREGVERIVRYAAELAR 185 Query: 185 KRR-------HKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDP 237 + +VT +DKANVL+S +REI + + + P +E+ H+ +D T+ +I+ P Sbjct: 186 DGQGAPADGVRRVTIVDKANVLRSYAFFREIADGVLADCPGIEVEHVIVDAMTVHMIERP 245 Query: 238 SQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIAN 297 FDV++C NLFGDILSD A I G MG+ PS + G ++ + GSAP IAGK +AN Sbjct: 246 EHFDVIVCENLFGDILSDLGAAIMGGMGLAPSGEIGRD-HGYFQGSHGSAPTIAGKGLAN 304 Query: 298 PIAQILSLALLLRYSLD------ADDAACAIERAINRALEEG-IRTGDLARGAAAVSTD 349 PIA ILS A++L + AA I A L+ G T D+ + S Sbjct: 305 PIACILSGAMMLDWLGKRHSDPALTRAAERIREATGAVLKAGRAVTPDIGGSGSTESCA 363 >UniRef50_Q7UTP0 3-isopropylmalate dehydrogenase n=1 Tax=Rhodopirellula baltica RepID=Q7UTP0_RHOBA Length = 364 Score = 334 bits (856), Expect = 3e-90, Method: Composition-based stats. Identities = 130/369 (35%), Positives = 210/369 (56%), Gaps = 18/369 (4%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRF-AMRITTSHYDVGGAAIDNHGQPLPP 59 M +++H+ +L GDGIGPEV Q++++L+ ++ + + VG G+ LP Sbjct: 1 MPQSFHLVILGGDGIGPEVCDQSVRLLEIMQPHLDGVEFQLDRHSVGVGEYQRSGEALPQ 60 Query: 60 ATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEA 119 + + C +DAVL G++G P ++ E L LR+ +L+ +RP +LY EA Sbjct: 61 SAYDACLASDAVLLGAMGLP---NVRYPNGKEIAPQLDLRERLQLYGGVRPIRLYH--EA 115 Query: 120 FCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIA 179 PL+ D + VRE T G+++G+ + ++A + R ER+ R+A Sbjct: 116 DTPLKGHGPGE-IDFVLVRESTEGLFYGRD--AIADLEADEATNLLRITRSASERVCRLA 172 Query: 180 FESARKR--RHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDP 237 FE+AR+R + VT IDKANVL S + +R + +E+A E+ D++ H+Y+D A + L++ P Sbjct: 173 FETARRRDGKKTVTLIDKANVLSSMVYFRHVFDEVAKEFLDIKAEHVYVDAAALFLVRRP 232 Query: 238 SQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIAN 297 FDV++ N+FGDILSD A + G MGM PS + + +++P+ GSAPDIAG++IAN Sbjct: 233 QDFDVMVTENMFGDILSDLAAGLVGGMGMAPSGDIGDDA-AVFQPSHGSAPDIAGQSIAN 291 Query: 298 PIAQILSLALLLRY--SLDADDAACAIERAINRALEEGI-RTGDLARGAAAVSTDEMGDI 354 PIA LS A++L + + AA A+ AI L + RT D+ +ST E+ D Sbjct: 292 PIAMHLSTAMMLEWLDHPETRRAADALNAAIADVLSDPTQRTADM---GGNLSTVEITDK 348 Query: 355 IARYVAEGV 363 IA +++ + Sbjct: 349 IAERLSKRL 357 >UniRef50_B1L3C1 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Korarchaeum cryptofilum OPF8 RepID=B1L3C1_KORCO Length = 334 Score = 330 bits (846), Expect = 6e-89, Method: Composition-based stats. Identities = 125/358 (34%), Positives = 189/358 (52%), Gaps = 33/358 (9%) Query: 5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEG 64 IAV+PGDG+GPE++ + VL+ + + + + ++ G G LP T+ G Sbjct: 2 PRIAVIPGDGVGPEIIDAVIPVLETLSDLMNLPLDLRFFEAGDETKRKRGVALPEETLNG 61 Query: 65 CEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 +DA L ++G + R +LPLR+ L+ NLRPAK Y + P Sbjct: 62 VMNSDATLMVAIG-----------ESAREVILPLRQKLDLYVNLRPAKSYP-VPRAIP-- 107 Query: 125 ADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESAR 184 GFD+ VRE T +Y G + A D + R ERI R + AR Sbjct: 108 ------GFDLTIVRENTEDLYV-----MSGWRGLDTAVDLRIITRRASERICRFGYRYAR 156 Query: 185 KRRH-KVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVL 243 +R +V + KANVL +L+RE+ + +A E + MY+D+A M++ D FDV+ Sbjct: 157 ERGKSRVYVVHKANVLGGCMLFREVCSRVAEE-EGFDYREMYVDSAAMRIAMD-RPFDVI 214 Query: 244 LCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQIL 303 + +N+FGDILSD A G +GM PSA++ E ++EP G+AP+IAGKNIANP+A IL Sbjct: 215 ITTNMFGDILSDLAAAFIGGLGMYPSANIGESR-AIFEPVHGTAPEIAGKNIANPMATIL 273 Query: 304 SLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYVAE 361 S A+++ + L + + IE A+ RA E G T D+ ++ T E+G I+ + E Sbjct: 274 SAAMMMGW-LGHEGGSKLIEEAVRRACELGYTTPDV---GGSMRTKEVGLKISEIMRE 327 >UniRef50_A9QPI0 Isocitrate/isopropylmalate dehydrogenase n=3 Tax=Bacteria RepID=A9QPI0_METI4 Length = 482 Score = 329 bits (845), Expect = 6e-89, Method: Composition-based stats. Identities = 110/368 (29%), Positives = 179/368 (48%), Gaps = 36/368 (9%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQP--LPPA 60 K I V GDGIGPE+M LKV+ + ++G + G P + P+ Sbjct: 2 KKVPITVAYGDGIGPEIMDATLKVILEA----GAELEIEKIEIGFKVY-SMGNPSGIEPS 56 Query: 61 TVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAF 120 + E ++ L + P+ + + +RK L++N+RP Y Sbjct: 57 SWESLKRTKVFLKAPITTPQGGGF-------KSLNVTVRKALGLYANIRPCISYAPFI-- 107 Query: 121 CPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAF 180 G D++ +RE +Y G + R+G ++ ++ R ERI R AF Sbjct: 108 -----HTKHPGIDLVIIRENEEDLY-GGIEHRQGVDSFQA---LKIMTRQGTERIIRYAF 158 Query: 181 ESAR-KRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPS 238 E AR R KV+S K N+L+ + ++ ++ E+A EYP +E H ID + +L +P Sbjct: 159 EYARCYGRKKVSSFTKDNILKITDGMFHKVFEEVAKEYPQIEKEHWIIDIGSAKLADNPQ 218 Query: 239 QFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANP 298 FDVL+ +NL+GDILSD I GS+G+ SA++ + + ++E GSAP AG+N+ANP Sbjct: 219 SFDVLVLANLYGDILSDVAVQIAGSVGLGASANIGHE-YSMFEAIHGSAPRRAGQNVANP 277 Query: 299 IAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAA---VSTDEMGDII 355 +L+ +L + + + A + A + +EEGI T D+ R + V T E Sbjct: 278 SGLLLAAVQMLIH-IGQNAVADRVYNAWLKTIEEGIHTYDIFREGVSKVKVGTREF---- 332 Query: 356 ARYVAEGV 363 AR+V + + Sbjct: 333 ARHVIKNL 340 >UniRef50_B0RIP4 3-isopropylmalate dehydrogenase n=140 Tax=Bacteria RepID=LEU3_CLAMS Length = 355 Score = 328 bits (842), Expect = 2e-88, Method: Composition-based stats. Identities = 139/366 (37%), Positives = 198/366 (54%), Gaps = 16/366 (4%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPA 60 M + +AV+PGDGIGPEV+ +AL+VL + + T+ Y G GQ L + Sbjct: 1 MPRTISLAVVPGDGIGPEVVHEALRVLREA-VPADVSLDTTQYPFGAGHFLETGQILTDS 59 Query: 61 TVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAF 120 + Q DA+L G+VGG + ERG LL LR F + NLRP L G+ + Sbjct: 60 DLAALAQHDAILLGAVGGDPRDARLAGGIIERGLLLKLRFAFDHYINLRPTALLPGVASP 119 Query: 121 CPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAF 180 A D + VRE T G Y G ++E A + V +ER R AF Sbjct: 120 L-----AAPGQVDFVVVREGTEGPYAGNGGVLRRGTEHEIATEVSVNTAHGVERTVRFAF 174 Query: 181 ESARKR-RHKVTSIDKANVLQSSI-LWREIVNEIATEYPDVELAHMYIDNATMQLIKDPS 238 E A KR R +VT + K NVL + LW+ V+ +A E+PDV + ++++D + L+ DPS Sbjct: 175 ELAEKRDRKRVTLVHKTNVLTFAGSLWQRTVDRVAAEHPDVTVDYLHVDATMIFLVTDPS 234 Query: 239 QFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQG--FGLYEPAGGSAPDIAGKNIA 296 +FDV++ NLFGDI++D A I+G +G+ S ++N G ++EP GSAPDIAG+ A Sbjct: 235 RFDVIVSDNLFGDIITDLAAAISGGIGLAASGNVNPTGAFPSMFEPVHGSAPDIAGQQKA 294 Query: 297 NPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIA 356 +P A ILS+ALLL + L +AA + A++ L TGD AA ST E+GD I Sbjct: 295 DPTAAILSVALLLDH-LGLSEAAARVSAAVSDDLAARA-TGD----AAPRSTAEVGDAIL 348 Query: 357 RYVAEG 362 R ++ Sbjct: 349 RALSTN 354 >UniRef50_C7RJH9 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Accumulibacter phosphatis clade IIA str. UW-1 RepID=C7RJH9_9PROT Length = 364 Score = 328 bits (841), Expect = 2e-88, Method: Composition-based stats. Identities = 125/371 (33%), Positives = 187/371 (50%), Gaps = 26/371 (7%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFA-MRITTSHYDVGGAAIDNHGQPLPPATV 62 +HIAVLPGDGIGPE++ +L VL+ + R + H + G A G + Sbjct: 6 RFHIAVLPGDGIGPEIVASSLHVLEVLNERMGGIGFDFWHLEGGAAHYQKTGTAFSDENM 65 Query: 63 EGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 C++ADAVL G++G P H+ E L LR L++ LRP + Y L Sbjct: 66 AACKKADAVLLGAIGLP---HVRYSDGTEVTTQLDLRVEMDLYAGLRPIRSYPSLPRVL- 121 Query: 123 LRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFES 182 D A+ D++ VRE T GI + + +G A++T + R R++ AF Sbjct: 122 --VDKRASQIDLVLVREQTEGILYSRCRG--TIEDDRVAWETMMISRNGTSRVSEFAFRV 177 Query: 183 A------RKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKD 236 A R+R KV +D++N L S +R I E+A +P V + Y+D M+L+K Sbjct: 178 AERRAKSRRRPGKVLCVDRSNALTSMAFFRRIFGEVAERHPSVSADYAYVDTTAMKLVKS 237 Query: 237 PSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIA 296 P +FDVL+ N FG ILSD A + GS+G+ PSA + E+ +++PA GSAP IAG+ +A Sbjct: 238 PWEFDVLVTENAFGGILSDLAAGVVGSLGLAPSADIGEK-HAVFQPAHGSAPHIAGQGLA 296 Query: 297 NPIAQILSLALLLRYSLDAD------DAACAIERAINRALEEGIRTGDLARGAAAVSTDE 350 NP+AQILS+AL+L + D A +E A+ +AL + T Sbjct: 297 NPVAQILSVALMLDWLADQHGEPRLAHGARILEHAVEKALT--VVCP--VEFGGKDGTAA 352 Query: 351 MGDIIARYVAE 361 + I + + Sbjct: 353 ITKAIIAQIRK 363 >UniRef50_Q05FQ8 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Carsonella ruddii PV RepID=Q05FQ8_CARRP Length = 349 Score = 327 bits (840), Expect = 3e-88, Method: Composition-based stats. Identities = 147/365 (40%), Positives = 218/365 (59%), Gaps = 25/365 (6%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 ++ +LPGDGIGPE++ Q +K++ + +I + +GG +ID P+ + Sbjct: 3 NLLILPGDGIGPEIIKQVIKIVKSCIY-TGYKINIIYNYIGGISIDKFNTPITNNLISII 61 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 + D + G VGG KW H +PE G LL LRK F F+N+RP K CP + Sbjct: 62 KYIDTIFLGCVGGYKWNH--SIFKPEYG-LLKLRKKFNFFTNIRPIK--------CPFK- 109 Query: 126 DIAANGFDILCVRELTGGIYFGQPKGRE----GSGQYEKAFDTEVYHRFEIERIARIAFE 181 DI+ VREL GGIY+G+PKG A++T++Y+ EI R+ARI+F Sbjct: 110 -----NIDIIIVRELNGGIYYGKPKGFSKQIINQIPTWYAYNTKIYNEQEIIRLARISFN 164 Query: 182 SARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFD 241 A R+ K+ SIDK+NVL++ LW++ +N + Y V+L+H+YID AT+ LIK+ ++FD Sbjct: 165 LALNRKKKLCSIDKSNVLETFKLWKKTINYVHKFYNKVKLSHIYIDYATIDLIKNFNKFD 224 Query: 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQ 301 V++ SNLFGDI+SD C+++TGS+GMLPS S+N + L+EP GSAPDIA KNIANP+ Sbjct: 225 VIITSNLFGDIISDLCSLLTGSLGMLPSISINNKSLSLFEPCHGSAPDIANKNIANPVGA 284 Query: 302 ILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLA---RGAAAVSTDEMGDIIARY 358 +LSL ++ Y L+ + + +I + L G T D+ R VST+E GD++ + Sbjct: 285 LLSLVMMFEYVLNDFKLSNNLYYSIYKVLSYGFCTIDMKKYIRNFKIVSTEEFGDLVNHF 344 Query: 359 VAEGV 363 V Sbjct: 345 FIINV 349 >UniRef50_Q0BQF4 Isocitrate dehydrogenase (NADP) n=14 Tax=Proteobacteria RepID=Q0BQF4_GRABC Length = 348 Score = 327 bits (839), Expect = 3e-88, Method: Composition-based stats. Identities = 126/366 (34%), Positives = 178/366 (48%), Gaps = 32/366 (8%) Query: 1 MSKNYHI--AVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLP 58 MS+ I ++PGDGIGPE++ + VLDA+ + F G AAI G PLP Sbjct: 7 MSQTTKIPATLIPGDGIGPEIVESVVSVLDALGSPF----EWDSQYAGMAAIARVGDPLP 62 Query: 59 PATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLE 118 T++ L G + P R + LRK F+LF+N+RPA Sbjct: 63 RETIQSIHHNKLALKGPLTTPTGGG-------YRSVNVQLRKEFELFANVRPA------- 108 Query: 119 AFCPLRADIAANGFDILCVRELTGGIYFGQPKGRE-GSGQYEKAFDTEVYHRFEIERIAR 177 L DI +RE G Y G + A R RI R Sbjct: 109 --LTLIPGGRFENVDITLIRENLDGFYAAFEHYMPIGDDPHAVAMCAGFNTRTGCHRIIR 166 Query: 178 IAFESARKR-RHKVTSIDKANVLQS-SILWREIVNEIATEYPD-VELAHMYIDNATMQLI 234 AFE A + R KVT + KAN+L++ + ++ E EIA EY + +D MQL+ Sbjct: 167 YAFEYAMQNGRKKVTLVHKANILKALTGIFLEAGKEIAKEYEGRIAFEERIVDACAMQLV 226 Query: 235 KDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKN 294 DP +FDV++ +NLFGDILSD A + G +G+ P ++ +Q ++E GSAPDIAGK Sbjct: 227 LDPGRFDVIVTTNLFGDILSDLIAGLIGGLGLAPGGNIGKQA-AIFEAVHGSAPDIAGKG 285 Query: 295 IANPIAQILSLALLLRYSLDADDAACAIERAIN-RALEEGIRTGDLARGAAAVSTDEMGD 353 IANP+A +L+ A++L + + D A + AI LE+GIRT DL A T E+ Sbjct: 286 IANPLALMLAAAMMLDH-VGKTDLATRLRNAIRITTLEDGIRTPDLGGTAK---TRELTQ 341 Query: 354 IIARYV 359 + + Sbjct: 342 ALISRI 347 >UniRef50_B8M3W0 3-isopropylmalate dehydrogenase n=6 Tax=Leotiomyceta RepID=B8M3W0_TALSN Length = 378 Score = 327 bits (838), Expect = 5e-88, Method: Composition-based stats. Identities = 153/382 (40%), Positives = 211/382 (55%), Gaps = 43/382 (11%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRF-AMRITTSHYDVGGAAIDNHGQPLPP 59 M++ + VLPGD IGPE++ +ALK+L + ++ S+ +GGA++D G + Sbjct: 1 MAEIRKLLVLPGDHIGPEIIAEALKILAVLEEELPNFKVQISYGLIGGASLDKTGSAITD 60 Query: 60 ATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLY-QGLE 118 +E +DAVL GSVGGP+W H+P PE+G +L LR+ F+N+RP + Y L Sbjct: 61 EVLETAVASDAVLLGSVGGPEWAHVPGALSPEKG-ILHLRQRLDAFANIRPCRFYASSLL 119 Query: 119 AFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARI 178 PL+ +IAA G D + VRE GG YFG E R E+ER AR+ Sbjct: 120 NQSPLKPEIAA-GVDFVLVRENCGGAYFGTKTEFEDEA------------RTEVERCARV 166 Query: 179 AFESARK-RRHK---------VTSIDKANVLQSSILWREIVNEI-ATEYPDVELAHMYID 227 + AR R K V + DKANVL S WR + ++I E+PD+EL D Sbjct: 167 SAALARTFGRGKNTDDKSPAIVWNADKANVLASGRFWRTVTHDIFEREFPDIELHDQLAD 226 Query: 228 NATMQLIKDPSQFD-VLLCSNLFGDILSDECAMITGSMGMLPSASL----NEQGF--GLY 280 + M ++K P++F+ V+ N FGDILSD I GS+G+LPSAS+ + G+Y Sbjct: 227 SMAMVMVKAPTKFNGVIHTDNTFGDILSDISGGIVGSLGVLPSASVCGVPGSEKPVKGIY 286 Query: 281 EPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEE------GI 334 E GSAPDI+G ANPIAQILSLA+LLRYS A +E A+ + LE GI Sbjct: 287 EAVHGSAPDISGTGQANPIAQILSLAMLLRYSFSMPRQADLLEDAVRKTLEVREHGGLGI 346 Query: 335 RTGDLARGAAAVSTDEMGDIIA 356 RT DL + ST ++GD +A Sbjct: 347 RTKDL---GGSASTQDVGDAVA 365 >UniRef50_C1F3J9 Isocitrate dehydrogenase n=1 Tax=Acidobacterium capsulatum ATCC 51196 RepID=C1F3J9_ACIC5 Length = 502 Score = 327 bits (838), Expect = 5e-88, Method: Composition-based stats. Identities = 99/358 (27%), Positives = 166/358 (46%), Gaps = 30/358 (8%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQP-LPPATVEGC 65 + V GDGIGPE+ + +L A + + +VG +P + Sbjct: 24 VTVAAGDGIGPEITAAVMSILSAA----GAHLDAEYVEVGEQVYLRGNTSGIPQEAWDSI 79 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 + +L G + P+ + + +RK L++N+RP + Y+ + Sbjct: 80 ARTRVMLKGPITTPQGGG-------YKSLNVTMRKTLGLYANVRPCRTYKPIVT------ 126 Query: 126 DIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARK 185 D++ VRE +Y G E + A ++ R ERIAR AFE AR+ Sbjct: 127 -TRHPDMDVVIVRENEEDLYAG----IEHRQTQDVAQCLKLITRSGSERIARYAFEYARQ 181 Query: 186 R-RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVL 243 R K+T + K N+++ + L+ + +E+A EYP+++ +D + P +DV+ Sbjct: 182 HGRSKITCMIKDNIMKLTDGLFHRVFDEVAREYPEIQAHSQIVDFGMANFVHRPEDYDVV 241 Query: 244 LCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQIL 303 L NL+GDILSD A +TGS+G+ S ++ G ++E GSAPD+A +++ANP +L Sbjct: 242 LLPNLYGDILSDIAAQMTGSVGLGGSVNIG-SGGAIFEAIHGSAPDLA-RDVANPSGLLL 299 Query: 304 SLALLLRYSLDADDAACAIERAINRALEEGIRTGDLAR--GAAAVSTDEMGDIIARYV 359 + +LR+ L D A + A LEEGI T D+A T + + + Sbjct: 300 AAVEMLRH-LKLDSIAAKVMNAWLCTLEEGIHTVDIAGAHTKERAGTRRFTEAVIERL 356 >UniRef50_O81796 Isocitrate dehydrogenase [NAD] regulatory subunit 3, mitochondrial n=42 Tax=Eukaryota RepID=IDH3_ARATH Length = 368 Score = 325 bits (833), Expect = 2e-87, Method: Composition-based stats. Identities = 98/363 (26%), Positives = 170/363 (46%), Gaps = 42/363 (11%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 + ++PGDGIGP V +V++A+ + Y+V G + + +P +E Sbjct: 40 TVTLIPGDGIGPLVTGAVEQVMEAMHA----PVHFERYEVLG-----NMRKVPEEVIESV 90 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 ++ L G + P + + LRK +F++L GL Sbjct: 91 KRNKVCLKGGLATPVGGGVS-------SLNMQLRKELDIFASLVNCINVPGLVT------ 137 Query: 126 DIAANGFDILCVRELTGGIYFG-QPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA- 183 DI+ +RE T G Y G + + G + +V +F ERIAR AFE A Sbjct: 138 --RHENVDIVVIRENTEGEYSGLEHEVVPGVVE-----SLKVITKFCSERIARYAFEYAY 190 Query: 184 RKRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDV 242 R KVT++ KAN+++ + L+ E E+A Y + + +DN MQL+ P QFDV Sbjct: 191 LNNRKKVTAVHKANIMKLADGLFLESCREVAKHYSGITYNEIIVDNCCMQLVAKPEQFDV 250 Query: 243 LLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSA----PDIAGKNIANP 298 ++ NL+G+++++ A I G G++P ++ + ++E + + + ANP Sbjct: 251 MVTPNLYGNLIANTAAGIAGGTGVMPGGNVGAE-HAIFEQGASAGNVGNDKMVEQKKANP 309 Query: 299 IAQILSLALLLRYSLDADDAACAIERAINRALEEG-IRTGDLARGAAAVSTDEMGDIIAR 357 +A +LS A++LR+ L A +E A+ + ++EG RT DL +T E+ D + Sbjct: 310 VALLLSSAMMLRH-LRFPTFADRLETAVKQVIKEGKYRTKDLGGDC---TTQEVVDAVIA 365 Query: 358 YVA 360 + Sbjct: 366 ALE 368 >UniRef50_P28241 Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial n=34 Tax=cellular organisms RepID=IDH2_YEAST Length = 369 Score = 322 bits (827), Expect = 8e-87, Method: Composition-based stats. Identities = 110/364 (30%), Positives = 178/364 (48%), Gaps = 38/364 (10%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHG-QPLPPATV 62 Y ++ + GDGIGPE+ K+ A + I DV + I +G +P V Sbjct: 36 KYTVSFIEGDGIGPEISKSVKKIFSAAN----VPIEWESCDV--SPIFVNGLTTIPDPAV 89 Query: 63 EGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 + + L G + P + R L LRK F LF+N+RPAK +G + Sbjct: 90 QSITKNLVALKGPLATPIG-------KGHRSLNLTLRKTFGLFANVRPAKSIEGFKT--- 139 Query: 123 LRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFES 182 D++ +RE T G Y G E ++ R ER+ R AFE Sbjct: 140 -----TYENVDLVLIRENTEGEYSG----IEHIVCPGVVQSIKLITRDASERVIRYAFEY 190 Query: 183 ARK-RRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQF 240 AR R +V + K+ + + + L+ + E++ EYPD+ L IDN+ ++++ +PS + Sbjct: 191 ARAIGRPRVIVVHKSTIQRLADGLFVNVAKELSKEYPDLTLETELIDNSVLKVVTNPSAY 250 Query: 241 D--VLLCSNLFGDILSDECAMI-TGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIAN 297 V +C NL+GDILSD + + GS+G+ PSA++ + ++E GSAPDIAG++ AN Sbjct: 251 TDAVSVCPNLYGDILSDLNSGLSAGSLGLTPSANIGHK-ISIFEAVHGSAPDIAGQDKAN 309 Query: 298 PIAQILSLALLLRYSLDADDAACAIERAINRALEEGI--RTGDLARGAAAVSTDEMGDII 355 P A +LS ++L + + + A I+ A+ + G RTGDLA A +T + + Sbjct: 310 PTALLLSSVMMLNH-MGLTNHADQIQNAVLSTIASGPENRTGDLAGTA---TTSSFTEAV 365 Query: 356 ARYV 359 + + Sbjct: 366 IKRL 369 >UniRef50_Q8XSY8 Probable 3-isopropylmalate dehydrogenase oxidoreductase protein n=2 Tax=Proteobacteria RepID=Q8XSY8_RALSO Length = 365 Score = 322 bits (827), Expect = 8e-87, Method: Composition-based stats. Identities = 112/366 (30%), Positives = 182/366 (49%), Gaps = 23/366 (6%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 I VLP DGIGPE++ A++VL + + F + + + DVG +++ +G L + Sbjct: 2 RILVLPCDGIGPEIVGAAMEVLRSADSVFKLDLAFDYDDVGFTSLEKYGTTLRDEVLAKA 61 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 + D V+ G P + R R L++N+RPA+ L + Sbjct: 62 KTYDGVILG---TQSHADYPAPDKGGRNVSAGFRIGLDLYANVRPARTRPFLTSNM---- 114 Query: 126 DIAANGFDILCVRELTGGIYFGQP---KGREGSGQYEKAFDTEVYHRFEIERIARIAFES 182 D++ +RE T G Y + E + A R ERIAR AFE Sbjct: 115 -REGRTMDLVIMREATEGFYPDRNMTKGWAELMPSPDMAISLRKITRHCSERIARRAFEL 173 Query: 183 ARKRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFD 241 A KR+ KVT+I KAN + L+ E V ++A ++P+V L + ID +T L++ P +FD Sbjct: 174 AMKRKKKVTAIHKANSFHMTDGLFLECVRDVARDFPEVRLDDLLIDASTAHLVRAPERFD 233 Query: 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQ 301 VL+ +N +GDI+SD + ++GS+G+ + + + GSAPDIAG++ ANP++ Sbjct: 234 VLVATNFYGDIISDLASELSGSLGLA-GSMMASDTHCCAQAQHGSAPDIAGQDKANPVSM 292 Query: 302 ILSLALLLRYSLDADD------AACAIERAINRALEE-GIRTGDLARGAAAVSTDEMGDI 354 ILS+A+L+++ + AA A+E A++ LE RT DL G + Sbjct: 293 ILSVAMLIQWMGEHHQNPAYLAAAQAMEAAVDSVLENPATRTPDLGGNCG---CKAFGQL 349 Query: 355 IARYVA 360 +A+ + Sbjct: 350 VAKVIQ 355 >UniRef50_D2VFR4 Homo-isocitrate dehydrogenase n=1 Tax=Naegleria gruberi RepID=D2VFR4_NAEGR Length = 384 Score = 322 bits (827), Expect = 9e-87, Method: Composition-based stats. Identities = 120/374 (32%), Positives = 188/374 (50%), Gaps = 44/374 (11%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAV------RNRFAMRITTSHYDVGGAAIDNHGQPLPPA 60 I V+P DGIG EV+ A++V++A + + + G G+ LP Sbjct: 34 IGVIPADGIGKEVVPAAVQVMNAAIAKNVKAKQNDFSLQYIPLEAGWETFQKTGKSLPVE 93 Query: 61 TVEGCE-QADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEA 119 TVE + + D +FGSV P + + ++ +RK L++N+RP + Sbjct: 94 TVEALKNKCDGAIFGSVQSPSHK-----VEGYSSPIVAMRKLVDLYANIRPCQDL----- 143 Query: 120 FCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEK-AFDTEVYHRFEIERIARI 178 A G D+L VRE T +Y + K EK A + +RIA I Sbjct: 144 ---------AKGIDMLIVRENTECLYIKKEKLTVDPTTGEKTAVADRLITERASKRIAEI 194 Query: 179 AFESARKRRH----KVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQL 233 A++ A +R KVT + K+NVL S L+RE EI+ +YP V+ +D+ ++ Sbjct: 195 AYKLAVQRNKNGAPKVTIVHKSNVLSVSDGLFRESCLEISKKYPQVKTEEQLVDSMVYKM 254 Query: 234 IKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGK 293 I DP+Q+DV++ NL+GDILSD + G +G+ SA+L++ F L EP GSAPDI GK Sbjct: 255 ILDPTQYDVVVAPNLYGDILSDAGSAFVGGLGVTASANLSDS-FALVEPVHGSAPDIFGK 313 Query: 294 NIANPIAQILSLALLLRYSLDAD-------DAACAIERAINRALEEG-IRTGDLARGAAA 345 I+NPIA I + A+LLR+ + D + A +++RA+N + + + T DL Sbjct: 314 KISNPIATIRACAMLLRHLQEKDPKCSYLNEIADSMDRAVNVVMPDKTVTTPDLGGKGN- 372 Query: 346 VSTDEMGDIIARYV 359 T+ + D I + + Sbjct: 373 --TETLVDAIIKNL 384 >UniRef50_A5FXZ9 3-isopropylmalate dehydrogenase n=2 Tax=Alphaproteobacteria RepID=A5FXZ9_ACICJ Length = 353 Score = 322 bits (826), Expect = 1e-86, Method: Composition-based stats. Identities = 118/370 (31%), Positives = 175/370 (47%), Gaps = 33/370 (8%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 I +L GD IG E++ +A++V+ A R + I +G AA+D+ G LP T+E Sbjct: 2 KIGILNGDDIGHEIVPEAVRVMQAAAARTGLAIEWQDIPIGRAALDSLGSTLPDGTIERL 61 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 + D L G +G + +P P LRKHF LF+N+RP K + L Sbjct: 62 DALDGWLLGPIGHMAYPKIPEAINPHP----LLRKHFDLFANIRPVKSHAALPCL----- 112 Query: 126 DIAANGFDILCVRELTGG------IYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIA 179 G D++ VRE G + G + R + V R ++AR A Sbjct: 113 ---HQGVDLVIVRENNEGFQPDRNVVAGSGEFRPTP---DVTISVRVITRNGSSKVARAA 166 Query: 180 FESARKRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPS 238 FE AR RR +T++ K V + ++ E +A EYPDV +D M+L+ P Sbjct: 167 FELARARRRHLTAVHKDTVFKLGCGMFAEECRRLAAEYPDVTYDEAIVDTFAMRLVMTPQ 226 Query: 239 QFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANP 298 ++DV++ +N+FGDIL+DE A + G +GM + + + GSAPDIAG+ IANP Sbjct: 227 RYDVVVTTNMFGDILTDEAAGLVGGLGMAAGLCAGPR-HAMAQATHGSAPDIAGRGIANP 285 Query: 299 IAQILSLALLLRYSLDAD------DAACAIERAINRALEE-GIRTGDLARGAAAVSTDEM 351 A I+S +LL + AA IE+A+ +EE T DL +T M Sbjct: 286 YAMIMSGQMLLDWLGRRHAEPAATAAARLIEQAVANMIEERRALTPDLGGQG---TTAGM 342 Query: 352 GDIIARYVAE 361 G I + E Sbjct: 343 GSAIIEAMTE 352 >UniRef50_P41564 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (Fragment) n=17 Tax=Bilateria RepID=IDH3G_MACFA Length = 355 Score = 322 bits (825), Expect = 1e-86, Method: Composition-based stats. Identities = 95/360 (26%), Positives = 159/360 (44%), Gaps = 32/360 (8%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 + + ++PGDGIGPE+M V + I N + Sbjct: 16 RHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFEEVHVSSNADEEDIRN--------AIM 67 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 + L G++ +LPP + LR L++N+ K G+ Sbjct: 68 AIRRNRVALKGNIET--NHNLPPSHKSRNNI---LRTSLDLYANVIHCKSLPGVVT---- 118 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 DIL VRE T G Y + +G E ++ + + RIA AF+ A Sbjct: 119 ----RHKDIDILIVRENTEGEYSS-LEHESVAGVVE---SLKIITKAKSLRIAEYAFKLA 170 Query: 184 R-KRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFD 241 + R KVT++ KAN+++ L+ + E+A YP + +M +DN TMQL+ P QFD Sbjct: 171 QESGRKKVTAVHKANIMKLGDGLFLQCCREVAARYPQITFENMIVDNTTMQLVSRPQQFD 230 Query: 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQ 301 V++ NL+G+I+++ CA + G G++ A+ + IA KNIANP A Sbjct: 231 VMVMPNLYGNIVNNVCAGLVGGPGLVAGANYGHVYAVFETATRNTGKSIANKNIANPTAT 290 Query: 302 ILSLALLLRYSLDADDAACAIERAINRALE-EGIRTGDLARGAAAVSTDEMGDIIARYVA 360 +L+ ++L + L A +I +A+ +++ E + T D+ +T E I R++ Sbjct: 291 LLASCMMLDH-LKLHSYATSIRKAVLASMDNENMHTPDIGGQG---TTSEAIQDIIRHIR 346 >UniRef50_A9FME3 3-isopropylmalate dehydrogenase n=7 Tax=Proteobacteria RepID=A9FME3_SORC5 Length = 363 Score = 321 bits (823), Expect = 3e-86, Method: Composition-based stats. Identities = 111/350 (31%), Positives = 182/350 (52%), Gaps = 17/350 (4%) Query: 17 PEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC-EQADAVLFGS 75 P V+ +A +L+ + R + I D+G G P + AVL G+ Sbjct: 19 PSVIAEAKLLLELYQERAGLPIDLWELDLGADRYLRDGTTFPNQIQIAIQRECSAVLLGA 78 Query: 76 VGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRADIAANGFDIL 135 +G P+ P+ + R L +R + L++N+RP + + PL+ A D + Sbjct: 79 LGDPR----VPNLEHARDILFGMRFGYDLYANVRPVRALS--DRLVPLKGRT-AKDIDFV 131 Query: 136 CVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARKR-RHKVTSID 194 RE T GIY G + E A + +V R +ERI R AF+ AR R +VT D Sbjct: 132 VFRENTEGIYVGMGGQFKRGTPDEVAINEDVNTRKGVERIIRAAFDYARANGRTRVTMAD 191 Query: 195 KANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDIL 253 K+N ++ + LW + +E+ +YP+++ H+Y+D + +I+DP QF V++ +NLFGDI+ Sbjct: 192 KSNAMRHAHELWLRVFHEVRAQYPEIQSNHVYVDALCLYVIQDPGQFQVIVTNNLFGDIV 251 Query: 254 SDECAMITGSMGMLPSASLN---EQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLR 310 +D A + G +GM SA+++ L+EP GSAP +AGK+IANP A +L+ LLL Sbjct: 252 TDLGAALQGGLGMAASANVHASDPARVALFEPVHGSAPPLAGKDIANPFAAMLTAGLLLA 311 Query: 311 YSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYVA 360 + L + IER +++AL++G+ T D+ + T G + +A Sbjct: 312 H-LGWPEEERRIERWVSQALDQGMCTVDV---GGTLGTRAAGAWVREQIA 357 >UniRef50_D1B742 3-isopropylmalate dehydrogenase n=2 Tax=Synergistaceae RepID=D1B742_THEAS Length = 370 Score = 320 bits (821), Expect = 5e-86, Method: Composition-based stats. Identities = 121/384 (31%), Positives = 188/384 (48%), Gaps = 42/384 (10%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATV 62 K+Y I ++PGDGIGPEV QA+KV++A + F + +HY G + Q LP + Sbjct: 2 KSYRIGLIPGDGIGPEVTAQAVKVMEAAGSLFGFSLELTHYPYGAEHYLSTRQVLPDHAL 61 Query: 63 EGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 E E DA+L G++G P+ + ERG LL LR HF ++N+RP + + P Sbjct: 62 EEMEGLDALLLGAIGDPRVQ----PGILERGILLKLRFHFDQYANIRPVRSF----TPGP 113 Query: 123 LRADIAANGFDILCVRELTGGIYFGQPKGREGSGQY-----------------------E 159 L + + +RE T +Y G +G+ Sbjct: 114 L------GSVNAVVIRENTEDLYVGIGSTGDGAVNLPLEVTRGGYVMKGQLSAFTTPPKR 167 Query: 160 KAFDTEVYHRFEIERIARIAFESARK-RRHKVTSIDKANVLQS-SILWREIVNEIATEYP 217 A + R + AF+ A +VT K+N ++ ++ +++A++Y Sbjct: 168 FAMQVAWHTLDGAARACQYAFDLALDLGAEEVTLATKSNAVRDLYGIFENACHQVASQYE 227 Query: 218 DVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGF 277 V L +D +L++ P F V+LC N+FGDI+SD A I G MG+ PS ++ ++ Sbjct: 228 SVSLRVENVDALCYKLVRSPGDFRVILCPNMFGDIVSDLLAGIGGGMGLAPSGNVGDR-L 286 Query: 278 GLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTG 337 ++EP GSAPDIAG++ ANP+A ILS A+LLR+ L AA A+E A+ R L + Sbjct: 287 SMFEPVHGSAPDIAGQDRANPVASILSGAMLLRH-LGETSAAKAMEDAVQRYLSGPVEEL 345 Query: 338 DLARGAAAVSTDEMGDIIARYVAE 361 + G + T GD + R + E Sbjct: 346 PIEMGGR-LGTRGAGDAVVRRLEE 368 >UniRef50_P51553 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial n=41 Tax=Euteleostomi RepID=IDH3G_HUMAN Length = 393 Score = 320 bits (820), Expect = 6e-86, Method: Composition-based stats. Identities = 94/360 (26%), Positives = 159/360 (44%), Gaps = 32/360 (8%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 + + ++PGDGIGPE+M V + I N + Sbjct: 54 RHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFEEVHVSSNADEEDIRN--------AIM 105 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 + L G++ +LPP + LR L++N+ K G+ Sbjct: 106 AIRRNRVALKGNIET--NHNLPPSHKSRNNI---LRTSLDLYANVIHCKSLPGVVT---- 156 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 DIL VRE T G Y + +G E ++ + + RIA AF+ A Sbjct: 157 ----RHKDIDILIVRENTEGEYS-SLEHESVAGVVE---SLKIITKAKSLRIAEYAFKLA 208 Query: 184 R-KRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFD 241 + R KVT++ KAN+++ L+ + E+A YP + +M +DN TMQL+ P QFD Sbjct: 209 QESGRKKVTAVHKANIMKLGDGLFLQCCREVAARYPQITFENMIVDNTTMQLVSRPQQFD 268 Query: 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQ 301 V++ NL+G+I+++ CA + G G++ A+ + IA KNIANP A Sbjct: 269 VMVMPNLYGNIVNNVCAGLVGGPGLVAGANYGHVYAVFETATRNTGKSIANKNIANPTAT 328 Query: 302 ILSLALLLRYSLDADDAACAIERAINRALE-EGIRTGDLARGAAAVSTDEMGDIIARYVA 360 +L+ ++L + L A +I +A+ +++ E + T D+ +T E + R++ Sbjct: 329 LLASCMMLDH-LKLHSYATSIRKAVLASMDNENMHTPDIGGQG---TTSEAIQDVIRHIR 384 >UniRef50_Q4ZRW7 3-isopropylmalate dehydrogenase n=13 Tax=Proteobacteria RepID=Q4ZRW7_PSEU2 Length = 396 Score = 320 bits (820), Expect = 6e-86, Method: Composition-based stats. Identities = 114/385 (29%), Positives = 170/385 (44%), Gaps = 50/385 (12%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 I VLPGDGIG EVM AL V+ A+ + D+G G+ +P T E Sbjct: 9 RICVLPGDGIGIEVMEAALPVIAALN----LPFDLVPADIGWQCWRAEGETVPARTWEIM 64 Query: 66 EQADAVLFGSVGGPKWEHLPPD--------QQPERGALLPLRKHFKLFSNLRPAKLYQGL 117 DA L G++ + + ++ LR++ L++N+RP G Sbjct: 65 ASCDATLLGAITSKPLAEAEAELPLTLQGQNRRYVSPVIQLRQNLDLYANVRPVTDMTG- 123 Query: 118 EAFCPLRADIAANGFDILCVRELTGGIYFGQPKGR-------------------EGSGQY 158 N F + +RE T G+Y G G + GQ Sbjct: 124 -----------ENRFRFVVIRENTEGLYAGLDFGCIPDALVPLLEEREALGAAWQREGQD 172 Query: 159 EKAFDTEVYHRFEIERIARIAFESARKRR-HKVTSIDKANVLQ-SSILWREIVNEIATEY 216 + + R + RI AFE ARK +VT +DK VL+ SS R I A Y Sbjct: 173 DATVTLRLQTRSGLMRIFEYAFEYARKNHFTRVTFVDKPMVLRHSSAFARGIFEATAQRY 232 Query: 217 PDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQG 276 PDV +D + +++ P +F V++ N+FGDILSD A + G +G PS + G Sbjct: 233 PDVSGVIENVDAVALWMVQRPERFGVIVAENMFGDILSDLGAGVMGGLGFAPSGNFGNSG 292 Query: 277 FGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRT 336 +EP GSAP AG N ANP A +++AL+L + ++AC I +A++ RT Sbjct: 293 -AYFEPVHGSAPAHAGLNKANPGAMFMAIALMLEHLGFPTESAC-ISQAVSLVSRTSTRT 350 Query: 337 GDLARGAAAVSTDEMGDIIARYVAE 361 DL + +T ++G+ I + E Sbjct: 351 YDL---GGSHTTAQVGEAIVQQCIE 372 >UniRef50_C7MQT6 Isocitrate/isopropylmalate dehydrogenase n=1 Tax=Saccharomonospora viridis DSM 43017 RepID=C7MQT6_SACVD Length = 356 Score = 319 bits (818), Expect = 1e-85, Method: Composition-based stats. Identities = 117/366 (31%), Positives = 177/366 (48%), Gaps = 26/366 (7%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHY--DVGGAAIDNHGQPLPPATVE 63 I ++ GDGIGPE++ ++VLDA+ + D G G A V Sbjct: 5 RIGLIRGDGIGPEIVEATVRVLDALAELHPESRGWEYVEIDAGADTYRRTGVACAEADVR 64 Query: 64 GCE-QADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 + DA L G VG P PD LR ++N+RP + + G+ + Sbjct: 65 RLRDEVDATLKGPVGLPDVR--TPDGVEAGVLGGILRTGLDTYANIRPVRSWPGVPS--- 119 Query: 123 LRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFES 182 + A+ D + VRE T G+Y + K G G DT + R R+AR AF Sbjct: 120 ---RVRADRVDYVIVRENTEGLYASRGK---GVGNRWAVTDTLLTTREGTLRVARKAFTL 173 Query: 183 ARKRR-------HKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIK 235 A R+ +VT +DK+NVL+S +RE+V E+A E+P+VEL + Y D A L+ Sbjct: 174 AAGRQGAPADGVRRVTCVDKSNVLRSHAFFREVVTEVAAEFPEVELEYRYADAAAQDLVL 233 Query: 236 DPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNI 295 P +FDVL+ N GD+LSD G +G+ P+ ++ + G +EP GSAPD+ G+N Sbjct: 234 CPERFDVLVMENFLGDVLSDLGGATVGGVGLCPAGNVGD-GAAYFEPVHGSAPDLVGRNR 292 Query: 296 ANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDE-MGDI 354 ANP+ Q+L+ A+LL + L D A + RA++ L G T + + E + D Sbjct: 293 ANPVGQLLAAAMLLDH-LGHVDEAARLRRAVSAVLAFG--TVRIEADGTVLGGAEAVADA 349 Query: 355 IARYVA 360 + + Sbjct: 350 VIAALQ 355 >UniRef50_A7SJV9 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7SJV9_NEMVE Length = 394 Score = 319 bits (817), Expect = 1e-85, Method: Composition-based stats. Identities = 91/360 (25%), Positives = 165/360 (45%), Gaps = 29/360 (8%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLP--PATVE 63 + ++PGDGIGPE++ + + + ++ G I + L + Sbjct: 52 TVTLIPGDGIGPEMVVAVQDIFR----HIGVPVDFEELNLSGLDIKDEDSYLGAFNEAIT 107 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 ++ + G++ P R L LR H LF+N+ K G++ Sbjct: 108 SIKRNGVAMKGNIFTP-----LDAIPGFRSLNLELRVHLDLFANIVRCKSIPGIQT---- 158 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 N D++ +R+ T G Y + SG E + +V +IA+ AF+ A Sbjct: 159 ----RHNNVDLVIIRQNTEGEYS-HLEHENVSGVIE---NLKVTTEEACMKIAQYAFDFA 210 Query: 184 RKR-RHKVTSIDKANVLQS-SILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFD 241 K R KVT++ KAN+++ L+ E++ YP++E M IDN MQL+ P QFD Sbjct: 211 EKHDRKKVTAVHKANIMKMGDGLFLRCCEEMSHSYPNIEFNSMIIDNCCMQLVAHPQQFD 270 Query: 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQ 301 V++ NL+G+I+S+ A + G G++P ++ + + DI GK+I+NPI+ Sbjct: 271 VMVLPNLYGNIVSNIGASLVGGPGIVPGENIGGDYAIFESGSRHTGLDIQGKDISNPISM 330 Query: 302 ILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYVAE 361 + + L+L + L+ A I AI + ++ G+ T D+ + +T + + + + Sbjct: 331 LFASTLMLEH-LEFTAYADLINSAILKVVQRGVLTADV---GGSHTTTQFLSALKSELDQ 386 >UniRef50_C4QCG1 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial, putative n=1 Tax=Schistosoma mansoni RepID=C4QCG1_SCHMA Length = 399 Score = 317 bits (812), Expect = 5e-85, Method: Composition-based stats. Identities = 90/359 (25%), Positives = 161/359 (44%), Gaps = 34/359 (9%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 + +A+L GDG+GPE+++ +V + I V + D + Sbjct: 68 RHTVAMLLGDGVGPELLSYVKEVFQVI----GAPIDFEEVAVNQESEDATFT----DALL 119 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 ++ + G+ + + + LR + L++ ++ + + G+ Sbjct: 120 AMKRNGVGIKGNFAT---------EPGQSSRNVALRLNLNLYAFVQRCRNFPGVVT---- 166 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 DI+ +RE T G Y + + G E ++ R + RIA+ AF+ A Sbjct: 167 ----RHQNVDIVIIRENTEGEYS-RLEHENVPGVVE---SLKIITREKSTRIAQFAFDYA 218 Query: 184 -RKRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFD 241 R R KVT++ KAN+++ L+ ++ + IA YP +E HM IDN MQL+ P QFD Sbjct: 219 VRHNRKKVTAVHKANIMKLGDGLFLDVCSSIAKNYPQIEFNHMIIDNTCMQLVTKPQQFD 278 Query: 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQ 301 V++ NL+G+I+ + A + G G+ +L Q S +AGKNIANP Sbjct: 279 VIVLPNLYGNIVGNVAAGLVGGAGLTTGINLGPQNALFEMGTRNSGRSLAGKNIANPCGM 338 Query: 302 ILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYVA 360 +L+ A +L Y +A + ++ E+ IRT DL + T ++ + + + + Sbjct: 339 LLTSADMLEYLGHIKEAKLIRDSVVDVIGEQKIRTADL---GGSFKTSKVIEAVLKSLR 394 >UniRef50_A1WHK9 3-isopropylmalate dehydrogenase n=5 Tax=Proteobacteria RepID=A1WHK9_VEREI Length = 356 Score = 316 bits (811), Expect = 7e-85, Method: Composition-based stats. Identities = 118/367 (32%), Positives = 182/367 (49%), Gaps = 25/367 (6%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 I VLPGDGIGPE+M A++VL+A RF + + H G A++ HG + PA +E Sbjct: 2 KIVVLPGDGIGPEIMAVAVRVLEAASKRFQLDLEIGHDIAGHASLQRHGATVTPALLEKV 61 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 + AD ++ G + ++ + + E RK L++N+RPA+ + G+ Sbjct: 62 KAADGLMLGPMATYDFKD---EAKGEINPSKFFRKELDLYANIRPARTFPGMAH------ 112 Query: 126 DIAANGFDILCVRELTGGIYFG---QPKGREGSGQYEKAFDTEVYHRFEIERIARIAFES 182 F++ VRE T G Y + E + R ERIAR AF+ Sbjct: 113 --RVGEFNLAVVRENTEGFYADRNIESGSSEMLITPDTVISLRRITRLCCERIARSAFDL 170 Query: 183 ARKRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFD 241 AR R V+ + KANVL+ ++ +I ++A E+P V + +D +++ P +FD Sbjct: 171 ARTRARHVSIVHKANVLKIGDGMFVDICRQVAREFPQVRVDDFIVDAMMAHVVRAPQRFD 230 Query: 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQ 301 V++ +N+FGDILSD A ++GS+G+ S + + + + GSAPDIAG+NIANP + Sbjct: 231 VIVTTNMFGDILSDLTAELSGSLGLGGSLNAGKD-HAMGQAVHGSAPDIAGRNIANPYSL 289 Query: 302 ILSLALLLRYSLDADD------AACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDII 355 ILS LL + + AA AI+ AL+ T D + T E G Sbjct: 290 ILSAGQLLGWHGQRKNLPAFALAARAIDETATAALQAREGTRD---AGGELGTAEAGQSF 346 Query: 356 ARYVAEG 362 R + EG Sbjct: 347 VRRLLEG 353 >UniRef50_C6V444 Isocitrate dehydrogenase n=2 Tax=Neorickettsia RepID=C6V444_NEORI Length = 471 Score = 316 bits (810), Expect = 8e-85, Method: Composition-based stats. Identities = 99/361 (27%), Positives = 170/361 (47%), Gaps = 33/361 (9%) Query: 5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHG-QPLPPATVE 63 + V GDG+GPE+MT L+++ I ++G + + + E Sbjct: 2 PKLTVAYGDGVGPEIMTSVLEIIFEA----GAEIQIDTIEIGQKIYEKGWPSGISDSGWE 57 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 ++ +L + P+ + R + LRK LF+N+RP K Sbjct: 58 TLKRNKVLLKAPITTPRGGGV-------RSLNVTLRKKLGLFANIRPCKS---------- 100 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 + DI+ +RE +Y G E + T+V ERI R AFE A Sbjct: 101 HLEWQDPKMDIVIIRENEEDLYSG----IEYRQTLDTYNCTKVITESTSERICRYAFEYA 156 Query: 184 RKR-RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFD 241 R R KVT + K N+++ + ++ ++ ++A EYPD+E + ID ++ K+P +FD Sbjct: 157 RSNGRKKVTVMVKDNIMKLTDGIFHKLFKKVALEYPDIESENYIIDIGAARIAKNPEKFD 216 Query: 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQ 301 V++ NL+GDI+SD A I+GS+G+ S ++ E+ + ++E GSAPDIA ++IANP Sbjct: 217 VIVTLNLYGDIISDIAAEISGSVGLGGSINIGEE-YAMFEAVHGSAPDIADQDIANPSGL 275 Query: 302 ILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLAR---GAAAVSTDEMGDIIARY 358 + + +L Y + + A + A + L+ G+ T D+ V T + + I Sbjct: 276 LNAAMYMLSY-IGQKEIAQKVYSAWLKTLKSGVHTADIFNPLHSKLKVGTKKFTEHIIHN 334 Query: 359 V 359 + Sbjct: 335 I 335 >UniRef50_B3RY01 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens RepID=B3RY01_TRIAD Length = 415 Score = 314 bits (804), Expect = 4e-84, Method: Composition-based stats. Identities = 96/359 (26%), Positives = 162/359 (45%), Gaps = 36/359 (10%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 Y + ++PGDGIGPE+ VL + ID + A + Sbjct: 87 RYTVTLIPGDGIGPEMARHVKTVLHKCGAPIDFEV-----------IDIKDESSTDAAII 135 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 ++ L G++ + +R+ L+SN+ P K G+ Sbjct: 136 SLKRNGIGLKGTITTNI------SNPQSQSINAQIRRKLDLYSNIVPCKSIPGVWT---- 185 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 D++ +RE T G Y G + G E ++ + RIA+ AF+ A Sbjct: 186 ----RHGQVDLVVIRENTEGEY-GSLEHENVDGVVE---SLKIITEKKSRRIAKFAFDYA 237 Query: 184 -RKRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFD 241 + R KVT+I KAN+++ + L+ E EI+ +Y D+E M IDN MQ++ +P QFD Sbjct: 238 LQNNRRKVTAIHKANIMKLADGLFLETCREISKDYTDIEFESMIIDNCCMQMVTNPQQFD 297 Query: 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQ 301 V++ NL+G+I+S + G +G++P ++ ++ A D+ G N ANP Sbjct: 298 VMVMPNLYGNIVSHIGIGLVGGIGLVPGKNIGDKYAIFESGARNIGSDLVGLNRANPCGF 357 Query: 302 ILSLALLLRYSLDADDAACAIERAINRALEEG-IRTGDLARGAAAVSTDEMGDIIARYV 359 + + AL+LR+ L DD A IE A+ ++ G RT D+ +T + D + + + Sbjct: 358 LFTSALMLRH-LGLDDYADIIESAVRTTIKNGKCRTPDIQGDR---TTADFIDAVIKEI 412 >UniRef50_D2SEJ6 3-isopropylmalate dehydrogenase n=3 Tax=Actinomycetales RepID=D2SEJ6_9ACTO Length = 340 Score = 313 bits (803), Expect = 5e-84, Method: Composition-based stats. Identities = 136/356 (38%), Positives = 198/356 (55%), Gaps = 25/356 (7%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 +AV+PGDGIGPEV+ + LKVL AV + ++ YD+G + G+ LP ++ Sbjct: 2 RLAVIPGDGIGPEVVAEGLKVLRAVAP----DVESTPYDLGASRWQRTGELLPDTVLDEL 57 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 + DA+L G++G P P ERG LL LR NLRPA+L+ G+ + Sbjct: 58 RRHDAILLGAIGDPS----VPPGILERGLLLRLRFELDHHVNLRPARLFDGVRSPL---- 109 Query: 126 DIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARK 185 A D+LCVRE T G Y G +E A + + F +ER+ R AFE A Sbjct: 110 -AAPGAIDMLCVREGTEGPYVGNGGVLRRDTPHEVATEVSLNTAFGVERVVRYAFERALA 168 Query: 186 R-RHKVTSIDKANVL-QSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVL 243 R R +T I K NVL + LW V E++ E+P+V +A+ ++D A+M + DP +FDV+ Sbjct: 169 RPRRHLTLIHKTNVLTHAGSLWSRTVEEVSAEFPEVTVAYQHVDAASMFFVTDPGRFDVI 228 Query: 244 LCSNLFGDILSDECAMITGSMGMLPSASLNEQG--FGLYEPAGGSAPDIAGKNIANPIAQ 301 + NLFGDI++D A +TG +G+ S +L+ G ++EP GSAPDIAGK +A+P A Sbjct: 229 VTDNLFGDIVTDLAAAVTGGIGLAASGNLDASGTNPSMFEPVHGSAPDIAGKGVADPTAT 288 Query: 302 ILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIAR 357 +LS+ LLL + AD A R +N A+ + T D A V T+++GD +A Sbjct: 289 VLSVGLLLDHLGRADQA-----RKVNAAVAFDLSTRD---PEAQVRTEDVGDRLAA 336 >UniRef50_Q4P2R4 3-isopropylmalate dehydrogenase n=1 Tax=Ustilago maydis RepID=Q4P2R4_USTMA Length = 363 Score = 312 bits (800), Expect = 1e-83, Method: Composition-based stats. Identities = 136/374 (36%), Positives = 205/374 (54%), Gaps = 37/374 (9%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPAT 61 K + + VL GD IGPEVM + L + D +++ F +++ T +GG+ +D H P+ +T Sbjct: 10 PKAFKVMVLQGDHIGPEVMAEVLPLFDVIQSHFGIKVETFERLIGGSCLDQHDCPIQEST 69 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 ++ + AVL GSVGGPKW+ ++PE G +L +RKH L++N+RPAK+ + Sbjct: 70 LQEASECHAVLLGSVGGPKWDVGDSSRRPETG-ILRMRKHLNLYANVRPAKIISERQLEL 128 Query: 122 PLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFE 181 + G +I+ +RE GGIYFG+ + + + A Sbjct: 129 SSLKEHVVRGVNIITLRENAGGIYFGRKQEPDPLAH-------------------KAALS 169 Query: 182 SARKRRH-KVTSIDKANVLQSSILWREIVNE-IATEYPDV--ELAHMYIDNATMQLIKDP 237 A + S+DKANV+ +S LWR++V E I E+P + +L+H +D+A M L KDP Sbjct: 170 LASSHGPLPIISVDKANVMATSRLWRQVVTETIRDEFPQLMDKLSHQLVDSAAMLLAKDP 229 Query: 238 SQFD-VLLCSNLFGDILSDECAMITGSMGMLPSASLN---------EQGFGLYEPAGGSA 287 + + V+L NLFGDILSD ++I GS+G+L SA ++ G+Y+P GSA Sbjct: 230 RKLNGVVLTENLFGDILSDLTSVIPGSLGVLGSAEIDGPPIPSQDFRMPMGVYQPVSGSA 289 Query: 288 PDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVS 347 PDIAGK IANPI +S L+ R+SL AA AI+ AI LE G T D+ +S Sbjct: 290 PDIAGKGIANPIGMFMSFGLMCRWSLGLPKAADAIDSAIKDCLESGQCTRDV---GGTLS 346 Query: 348 TDEMGDIIARYVAE 361 T + G + + + E Sbjct: 347 TQQAGSALRQSIQE 360 >UniRef50_A0D2B8 Chromosome undetermined scaffold_35, whole genome shotgun sequence n=4 Tax=Oligohymenophorea RepID=A0D2B8_PARTE Length = 355 Score = 312 bits (799), Expect = 2e-83, Method: Composition-based stats. Identities = 100/358 (27%), Positives = 167/358 (46%), Gaps = 42/358 (11%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 ++ ++PG GIGPE+ V +A+ H + +DN + Sbjct: 34 NVTLIPGVGIGPEITNSVKTVFEAL-----------HVPIKFDVLDNFNFE-NDDSKSQL 81 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 + + +L G + ++ + K+ L+SN+ A +G+ Sbjct: 82 RKNECILLG---------VMTEKNQKYTDNYKFYKYLDLYSNITFAFSVEGITQ------ 126 Query: 126 DIAANGFDILCVRELTGGIYFG-QPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA- 183 N DI+ +RE T G Y G + + G + +V + RIA AFE A Sbjct: 127 --RHNNTDIVVIRENTEGEYSGVEHEVYPGVVE-----SIKVTTKQASLRIAEYAFEFAH 179 Query: 184 RKRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDV 242 R KVT++ KAN+++ L+ + E+A Y ++ M IDN MQL+K+P+QFDV Sbjct: 180 LSGRRKVTAVHKANIMKLVDGLFLQACREVAQRYSFIKYEEMIIDNCCMQLVKNPTQFDV 239 Query: 243 LLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQI 302 ++ NL+G I+ + A ITG +GM AS+ + + + DIAGKN+ NP A + Sbjct: 240 MVMPNLYGSIVQNVVAGITGGVGMAAGASIGKDHALFSQGCRHTGRDIAGKNVVNPSAML 299 Query: 303 LSLALLLRYSLDADDAACAIERAINRALEE-GIRTGDLARGAAAVSTDEMGDIIARYV 359 +S LLLR+ L + A I RA+ +++ I+T D+ A +TD+ + R + Sbjct: 300 VSSTLLLRH-LGLPNFADQICRAVQHTIQDKKIKTKDIGGNA---TTDQFTSEVIRSL 353 >UniRef50_D2RVT1 Isocitrate dehydrogenase, NADP-dependent n=1 Tax=Haloterrigena turkmenica DSM 5511 RepID=D2RVT1_9EURY Length = 425 Score = 312 bits (799), Expect = 2e-83, Method: Composition-based stats. Identities = 108/411 (26%), Positives = 166/411 (40%), Gaps = 66/411 (16%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQP--LPP 59 N I ++ GDGIG +V A KVL+A I+ G +A + +G+ LP Sbjct: 28 PDNPIIPIIHGDGIGKDVGPAAQKVLEAAAEATGRDISWMRVYAGESAREEYGEDVNLPD 87 Query: 60 ATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEA 119 TV+ + + G + P R + LR+ L++N+RP G+ Sbjct: 88 ETVDAIREHRVAIKGPLTTPVGAGF-------RSLNVALRQTLDLYANVRPTYYLDGVP- 139 Query: 120 FCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEK------------------- 160 P++ A D++ RE T +Y G + G+ + E+ Sbjct: 140 -SPMK---APEEMDMVTFRENTEDVYAGI-EWEAGTDEVEQVREFVEDEMGFDETMHDGP 194 Query: 161 -AFDTEVYHRFEIERIARIAFESARKR-RHKVTSIDKANVLQ-SSILWREIVNEIA-TEY 216 + +R+ R A + A + R KVT + K N+++ + + + E+A EY Sbjct: 195 IGIGLKPITEKGSKRLVREAIDYALEHDRDKVTLVHKGNIMKFTEGQFGDWGMEVADEEY 254 Query: 217 PD-----------------------VELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDIL 253 PD V + D + +FD+L NL GD L Sbjct: 255 PDDEVFAAPDSLWETQDEVDIPEDAVMVEERLADAMLQWMQLRTDEFDILAMPNLNGDYL 314 Query: 254 SDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSL 313 SD G +G+ P + +G L EP GSAP AG+++ANP A ILS L+ Y L Sbjct: 315 SDAAGAQIGGLGIAPGGNFG-KGRMLAEPVHGSAPKRAGQDMANPTAMILSGRLMFDY-L 372 Query: 314 DADDAACAIERAINRALEEGIRTGDLAR---GAAAVSTDEMGDIIARYVAE 361 DDAA I A+ + G T DL R A + T E D I + + Sbjct: 373 GWDDAADLIRDAVEETISSGKVTYDLERQLEDAEKLGTSEYTDEIVDTIEK 423 >UniRef50_B8NJA6 3-isopropymalate dehydrogenase, putative n=3 Tax=cellular organisms RepID=B8NJA6_ASPFN Length = 350 Score = 311 bits (797), Expect = 3e-83, Method: Composition-based stats. Identities = 110/364 (30%), Positives = 170/364 (46%), Gaps = 29/364 (7%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 I VL G+GIGPE+ ++V++A ++ + A+ +G LPP ++ Sbjct: 2 RIGVLKGNGIGPEITAATIRVIEAT----GIQPEWDFIPIADEAVRLYGHALPPQVIQRI 57 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGA------LLPLRKHFKLFSNLRPAKLYQGLEA 119 + + + K Q + +R+ LF N RP + Y G+ Sbjct: 58 KDVKFCIKAPLLAEKLHGRISCTQTDGSVVTYPSINNAIRRELNLFVNPRPIRGYVGISG 117 Query: 120 FCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIA 179 D++ +RE+T Y G K E E + R ++++ A Sbjct: 118 --------RHEKMDMVIMREITEDTYIGWEKPLEDGAAAEA---IKRVTRSASWKVSQYA 166 Query: 180 FESARKR-RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDP 237 FE ARK R KV+ + KANVL + L+ E+A YPD+ M ID A +++DP Sbjct: 167 FEYARKHGRKKVSCLHKANVLHETDGLFLRTFQEVARLYPDIVGDDMMIDAACYSVVRDP 226 Query: 238 SQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIAN 297 FDV++ N +GDI SD A + GS+G+ P A++ + +E A G+APDIAG AN Sbjct: 227 CWFDVVVTVNQYGDIFSDLAAGLAGSLGLAPGANIGDSA-STFEAAHGAAPDIAGTGAAN 285 Query: 298 PIAQILSLALLLRYSLDADDAACAIERAINRALEEG-IRTGDLARGAAAVSTDEMGDIIA 356 PIA ILS A LL ++ + AI A+ R +E G T DL +T+++ D I+ Sbjct: 286 PIALILSGAELLAHA-GYGKGSEAIREAVTRVIEAGRTLTPDL---GGRSTTEQVADAIS 341 Query: 357 RYVA 360 V Sbjct: 342 VEVR 345 >UniRef50_C5EHC0 3-isopropylmalate dehydrogenase n=1 Tax=Clostridiales bacterium 1_7_47FAA RepID=C5EHC0_9FIRM Length = 369 Score = 311 bits (797), Expect = 3e-83, Method: Composition-based stats. Identities = 126/359 (35%), Positives = 200/359 (55%), Gaps = 5/359 (1%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPAT 61 S+ Y IA++PGDG+GPE+ +A+ L + + G AA+D PLP + Sbjct: 11 SRIYTIALIPGDGVGPEITREAVLTLKRAGEVYGRSFQFTEAIAGTAALDRGQCPLPRES 70 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 ++ C +AD++L G + + L +++PE L LR L S++RP + L C Sbjct: 71 LKTCLEADSILMGKLAVGRHPGLKFEERPE-SILGLLRTGLCLRSDIRPCFFAEALRELC 129 Query: 122 PLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFE 181 PL+ +I G DIL +R++ GG++ + K A+DTE Y I AR+AF+ Sbjct: 130 PLKEEIRKKGMDILIIRDIAGGMFTTEGKSSN-LCNVRAAWDTESYDETLIRDSARLAFQ 188 Query: 182 SARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFD 241 A R+ KVTS+DKA +L SS+LWR+I+ E +YP++EL HM +D+ +L+ P FD Sbjct: 189 LAASRKRKVTSLDKAILLSSSVLWRQILEETHRDYPEIELEHMLVDHGAFKLVSSPDAFD 248 Query: 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEP--AGGSAPDIAGKNIANPI 299 V++ SN+FGDI++DE A +TG+ LP+ SLN + G+Y P ++AG ANP+ Sbjct: 249 VIVASNVFGDIIADEAAGLTGAGEFLPAGSLNAERKGIYCPNQLHQVHEELAGTGRANPV 308 Query: 300 AQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVS-TDEMGDIIAR 357 IL+ A++L YS A ++RA++ +E+GI G + T +G+ + Sbjct: 309 GMILAAAMMLEYSFGLVREAEGMKRAVSIVMEQGIHGRPCWSGGEQTADTAAIGEAVRE 367 >UniRef50_B7PN53 Isocitrate dehydrogenase, putative (Fragment) n=1 Tax=Ixodes scapularis RepID=B7PN53_IXOSC Length = 381 Score = 311 bits (797), Expect = 3e-83, Method: Composition-based stats. Identities = 93/362 (25%), Positives = 168/362 (46%), Gaps = 32/362 (8%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 + + +LPG GIGPE+M + + +VG A+ +H ++ Sbjct: 47 RFFVTLLPGHGIGPEMMRHVEAIFACGKVPVDFETIIVDANVGDASSMDH-------AIK 99 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 + L G++ + + L LR +L+ N+ + + G+ Sbjct: 100 SIRRNGVALKGNIETTSYSMTVEPR------NLLLRNKLELYVNVVHCRNHPGI------ 147 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 + G DI+ +R+ T G Y + SG E ++ + +IA+ FE A Sbjct: 148 --NTKHKGVDIVVIRQNTEGEYS-CLEHEVTSGVVE---SLKIITWAKSFQIAKYCFEYA 201 Query: 184 RKR-RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFD 241 R R KVT + KAN+++ + L+ + E+A EYPD+EL + IDN MQL+ +P+QFD Sbjct: 202 RTHMRKKVTVVHKANIMKLTDGLFLKTCTEVAQEYPDIELNDIIIDNCCMQLVANPAQFD 261 Query: 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQ 301 V+L NL+G+I+ + + G G+ + ++ + + GKN+ANP+A Sbjct: 262 VMLVPNLYGNIVVNVACGLVGGAGVTSGRNYGKEYAVFETATRNTGTPLVGKNLANPVAT 321 Query: 302 ILSLALLLRYSLDADDAACAIERAINRAL-EEGIRTGDLARGAAAVSTDEMGDIIARYVA 360 + + +L++ L+ D A I RAI + + + + T DL A +T ++ + I + V Sbjct: 322 LYAAVDMLKH-LELWDHAVVIRRAIEKTVNRDKVHTKDLGGDA---TTSKVVENILKEVQ 377 Query: 361 EG 362 + Sbjct: 378 KN 379 >UniRef50_UPI0001AF2578 isocitrate dehydrogenase [NADP] (oxalosuccinatedecarboxylase) (idh) (nadp(+)-specific icdh) n=1 Tax=Streptomyces roseosporus NRRL 15998 RepID=UPI0001AF2578 Length = 372 Score = 310 bits (795), Expect = 4e-83, Method: Composition-based stats. Identities = 95/378 (25%), Positives = 157/378 (41%), Gaps = 34/378 (8%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATV 62 + Y + ++PGDG GPE++ A VLD +I + G A+ LP AT+ Sbjct: 2 RTYEVTLVPGDGSGPELVDAARSVLDHAARLSGFKIDWDVHQAGQRALAESESLLPDATL 61 Query: 63 EGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 A L G P R + +R+ L++ LRP + Sbjct: 62 NSIRTNGAALKGPTTTPIG-------TGHRSVNITIRQELDLYACLRPVRSLP----IAS 110 Query: 123 LRADIAANGFDILCVRELTGGIYFG--QPKGREGSG-------------QYEKAFDTEVY 167 + + D++ VRE T +Y G PKG G+ + A + + Sbjct: 111 TQEEPERPHVDLVVVRENTEDVYAGLEYPKGSPGARAVVQALGALGRPLPADTAVSLKPF 170 Query: 168 HRFEIERIARIAFESARKRRHKVT--SIDKANVLQSSILWREIVNEIATEYPDVELAHMY 225 ER+ AF A + K+ D + ++ + +++A +P + + Sbjct: 171 TPHGCERVVEFAFNHAARHGRKLVESVCDARRYPATEGMFARVASKVAARHPSIASRTVP 230 Query: 226 IDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGG 285 + L++ P + DVL+ NL+GDI+SD A + GS+G+ P A++ ++E G Sbjct: 231 VPALCADLVRAPGRHDVLVLPNLYGDIISDVTAALVGSLGVAPGANIGAH-HAVFEATHG 289 Query: 286 SAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEG-IRTGDL---AR 341 SAP+ AG NP A I S +LL + L + A I A+ + G + T DL R Sbjct: 290 SAPEFAGSGRLNPTALIFSGCMLLDH-LGEHETAARIRAAVEDVVAAGEVLTFDLLAPQR 348 Query: 342 GAAAVSTDEMGDIIARYV 359 A A +T E + + Sbjct: 349 SADAATTVEFTRAVTDRL 366 >UniRef50_Q0X0C1 Putative dehydrogenase n=2 Tax=Streptomyces RepID=Q0X0C1_9ACTO Length = 362 Score = 310 bits (795), Expect = 5e-83, Method: Composition-based stats. Identities = 130/357 (36%), Positives = 186/357 (52%), Gaps = 19/357 (5%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 IAV+PGDGIGPEV+ AL VLDA+ R + V G+ L + ++ Sbjct: 21 TIAVIPGDGIGPEVIEPALDVLDALG--LGTRTDILDH-VNADTYLRTGEALTGSDLDRI 77 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 ++A L G+VG P+ D RG L LR L+ N RPA+L+ + PLR Sbjct: 78 RSSEAALLGAVGDPRLG----DTSYVRGVLTTLRLELDLYVNYRPARLWH--DRLSPLR- 130 Query: 126 DIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARK 185 D A D + VRE T G+Y G G E A D ++ R + R+ AF +A Sbjct: 131 DPARRAIDCVIVRENTEGLYSGIGGGARTGTPEEIAVDVDLSTRHGVSRVLEFAFSAA-- 188 Query: 186 RRHKVTSIDKANVLQSSI-LWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLL 244 R V +DKAN +++ LW+ E +P + +H+Y+D A ++L DP+ FDV++ Sbjct: 189 -RRSVCLVDKANAVRNGGQLWQRCWGEAVARHPHIATSHLYVDTAALRLATDPTGFDVIV 247 Query: 245 CSNLFGDILSDECAMITGSMGMLPSASLNE-QGFGLYEPAGGSAPDIAGKNIANPIAQIL 303 +N +GDILSD A + G +G+ SA+LN G L+EP GSAPDIAG ANP IL Sbjct: 248 TNNSYGDILSDLTAALAGGLGVAASANLNPVTGRALFEPVHGSAPDIAGSGTANPFGAIL 307 Query: 304 SLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYVA 360 S+ALL + L ++ A A+ RA+ A+ G T DL + T E+G + + Sbjct: 308 SVALLAEH-LGRNEEADAVRRAVAAAVAAGRVTPDL---GGPLGTKEVGAAVLAELR 360 >UniRef50_B2J8P1 3-isopropylmalate dehydrogenase n=3 Tax=Cyanobacteria RepID=B2J8P1_NOSP7 Length = 363 Score = 310 bits (795), Expect = 5e-83, Method: Composition-based stats. Identities = 145/358 (40%), Positives = 194/358 (54%), Gaps = 20/358 (5%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 +Y I +PG+GIGPEV+ +LK+L V + + +G A + G P AT E Sbjct: 8 SYRIVAIPGEGIGPEVVEASLKILQHVAKIQGFTLQVDYGWLGATAFEQLGSYFPQATTE 67 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 C+ AD ++FG+V +G LL LRKHF F NLRP + L L Sbjct: 68 LCDGADGIVFGAV--------------SQGGLLELRKHFDFFCNLRPIRSVNSLLHKSSL 113 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 R + G DIL VREL GIYFG P GR + + T Y+ EI RIAR A E A Sbjct: 114 RPE-KIQGLDILIVRELVSGIYFG-PSGRSSDERGNYGYHTMRYYDEEIRRIARKALEQA 171 Query: 184 RKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVL 243 + RR +T K N L W +V E AT++P+V + M +DN MQ++ +P +FDV+ Sbjct: 172 QYRRGLLTVAHKENALPHLH-WTRLVQEEATKFPNVIVEPMLVDNLAMQMVLNPQRFDVI 230 Query: 244 LCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQIL 303 L SNLFGDILSD + GS+G+L SASLN GFGLYE G+APDIAG IANP+ + Sbjct: 231 LASNLFGDILSDIGGALVGSIGLLGSASLNANGFGLYEAIHGTAPDIAGLGIANPLGTLG 290 Query: 304 SLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAA--VSTDEMGDIIARYV 359 + L+L+ AA I A +R L +G RT DL V+T + D++ + Sbjct: 291 ACVLMLQ-QWGEVQAAQQIIAAQDRILAKGYRTADLFTQGEEILVNTATLVDLLLEEL 347 >UniRef50_Q5JFV8 Homoisocitrate dehydrogenase n=4 Tax=Thermococcaceae RepID=Q5JFV8_PYRKO Length = 347 Score = 309 bits (793), Expect = 8e-83, Method: Composition-based stats. Identities = 133/356 (37%), Positives = 185/356 (51%), Gaps = 37/356 (10%) Query: 5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEG 64 Y +AV+PGDGIGPEV+ A++VL AV R + +Y+ G G P+ +E Sbjct: 2 YRVAVIPGDGIGPEVIDGAVRVLKAVTGR----VRFEYYEGGVDVFQECGSPIREEDLEE 57 Query: 65 CEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 ++DAVLFG+ P D R +L LRK L++NLR + L Sbjct: 58 IRRSDAVLFGATTTP------FDLPGYRSLILTLRKELGLYANLR---IIPDLRT----- 103 Query: 125 ADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESAR 184 G +I+ VRE + G+YFG G +A D + R ERIAR A E A+ Sbjct: 104 ------GREIVIVRENSEGLYFGIGAVVNG-----RAVDVRLITREGAERIARFAVEQAK 152 Query: 185 KRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLL 244 R +T + KANVL +R IV E+A E VE+ ID+ T++L+++P + V+L Sbjct: 153 ARGSFITFVHKANVLTGDKFFRRIVREVAGE-EGVEVRDAIIDSFTIKLVRNPWEHGVIL 211 Query: 245 CSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILS 304 NLFGDILSD + GS+G++PS + + G L+EP GSAPDIAGK IANPI ILS Sbjct: 212 SENLFGDILSDLATVHAGSIGIVPSGNYGD-GIALFEPVHGSAPDIAGKGIANPIGAILS 270 Query: 305 LALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYVA 360 A+LL Y L D I A+ + G T D+ A T+++ I + Sbjct: 271 GAMLLDY-LGLD--GSLIRAAVRGYVVNGELTPDMGGRAR---TEDVVRGIIGEIE 320 >UniRef50_D1B6F8 3-isopropylmalate dehydrogenase n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B6F8_THEAS Length = 420 Score = 309 bits (792), Expect = 1e-82, Method: Composition-based stats. Identities = 120/394 (30%), Positives = 176/394 (44%), Gaps = 55/394 (13%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDN----------H 53 Y + +PGD G ++M AL VL + I D+G + Sbjct: 14 RYKVCYMPGDDSGFDMMEGALVVL----LSMDLPIDWVRADLGWCMWEKSVNKFGQGDPR 69 Query: 54 GQPLPPATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKL 113 +PP T++ +DA L ++ + + A+L +R+ F L+ NLRPAK Sbjct: 70 CNTVPPETIDKIRSSDATLMAAITSKSG------VKGFKSAILQMRQLFDLYINLRPAKT 123 Query: 114 YQGLEAFCPLRADIAANGFDILCVRELTGGIY------------FGQPKGREGSGQY-EK 160 L PL+ D D++ RE T +Y F KG E + + Sbjct: 124 LPDLG--SPLKGDPK---IDLVLFRENTEDLYSAVEFHPLPEEMFNLHKGMERFRKMGDV 178 Query: 161 AFDTEVYHRFEIERIARIAFESARK-RRHKVTSIDKANVLQ-SSILWREIVNEIATEYPD 218 A V+ ERI R AFE A+ R KV +KANV++ + + + I E+A EY Sbjct: 179 AVSWRVFSSVGCERIIRAAFEYAKSTGRTKVHCCNKANVIRETDGMMKRIFLEVAKEYEQ 238 Query: 219 --VELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQG 276 + D M LIK+P + V++ SN+FGDILSDE + +TG +G PS ++ E Sbjct: 239 YGITGIEENADATAMWLIKNPQDYQVIVTSNVFGDILSDEASQLTGGLGFAPSGNIGEN- 297 Query: 277 FGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEE---G 333 ++EP GS P A + NP A +L+ ++L Y L D A IE AIN L+E Sbjct: 298 TAIFEPCSGSVPKYAHQYRVNPSAMLLTSKMMLEY-LGLDQAGQKIEWAINEVLKENRPK 356 Query: 334 IRTGDLARG--------AAAVSTDEMGDIIARYV 359 T D+ R A ST EM IA+ + Sbjct: 357 TLTYDILRDFRNDPDWERNAASTIEMATAIAQKI 390 >UniRef50_O13696 Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial n=76 Tax=Fungi/Metazoa group RepID=IDH1_SCHPO Length = 356 Score = 308 bits (789), Expect = 2e-82, Method: Composition-based stats. Identities = 97/363 (26%), Positives = 156/363 (42%), Gaps = 32/363 (8%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNH--GQPLPPAT 61 Y + ++PGDGIG E ++ + I DV G +N G L Sbjct: 20 KYTVTLIPGDGIGRETSNAVTEIFKTAN----VPIEFEEIDVTGMEKNNKSSGDALH-EA 74 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 ++ ++ L G + P ++ + LRK ++++L K G + Sbjct: 75 IQSLKRNKVGLKGILFTP------FEKGGHTSFNVALRKELDIYASLVLIKNIPGFKT-- 126 Query: 122 PLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFE 181 + D +RE T G Y G + + G E ++ ++ +RIA+ AF+ Sbjct: 127 ------RHDNVDFAIIRENTEGEYSG-LEHQSVPGVVE---SLKIITEYKSKRIAQFAFD 176 Query: 182 SARKR-RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQ 239 A + R VT I KAN+++ + L+R ++A Y + + +DNA+MQ + P Q Sbjct: 177 FALQNGRKSVTCIHKANIMKLADGLFRRTFYDVANGYDAITPKDLIVDNASMQAVSRPQQ 236 Query: 240 FDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPI 299 FDVL+ NL+G ILS+ + + G G++P A+ I G+ ANP Sbjct: 237 FDVLVMPNLYGSILSNIGSALVGGPGVIPGANFGRDYALFEPGCRHVGLSITGRGEANPT 296 Query: 300 AQILSLALLLRYSLDADDAACAIERAINRALEEG-IRTGDLARGAAAVSTDEMGDIIARY 358 A ILS L+LR+ L D A I A +EEG T DL + ST + I Sbjct: 297 AAILSACLMLRH-LGLKDYADLINAATYSVIEEGKTLTKDL---GGSASTGDFTHAILER 352 Query: 359 VAE 361 + Sbjct: 353 MES 355 >UniRef50_Q1IMD5 3-isopropylmalate dehydrogenase n=3 Tax=cellular organisms RepID=Q1IMD5_ACIBL Length = 403 Score = 307 bits (788), Expect = 3e-82, Method: Composition-based stats. Identities = 114/405 (28%), Positives = 190/405 (46%), Gaps = 49/405 (12%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPA 60 M++ + +PGDGIG +V+ QA++VL+AV H D+G N G LP Sbjct: 1 MARP-TVVTMPGDGIGNQVLPQAIRVLEAV----GFEANYVHADIGWECWCNEGNALPDR 55 Query: 61 TVEGCEQADAVLFGSVGGPKWEHLPPDQQPER--------GALLPLRKHFKLFSNLRPAK 112 T++ + LFG++ + + +PE ++ +R+ F L +RP Sbjct: 56 TIQLLRKHKLGLFGAITSKPKKAADAELKPELRGKGLSYFSPIVTMRQLFNLDVCMRPCL 115 Query: 113 LYQGLEAFCPLRA---DIAANGFDILCVRELTGGIYFGQPKGRE---------------- 153 + G + D++ R+ T G+Y G Sbjct: 116 SFPGNPLNFIRQTTCGGFEEPQVDVVVFRQNTEGLYAGVEWTNPPENVRTALASHKKFAA 175 Query: 154 --GSGQYEKAFDTEVYHRFEIERIARIAFESARKRRHK-VTSIDKANVLQ-SSILWREIV 209 + E A + + +RI AF+ A+K R+K VT +K NVL+ +S + E+ Sbjct: 176 FANTPGEELAVSVRIITKKNAQRICEAAFKHAKKYRYKNVTICEKPNVLRETSGMMEEVA 235 Query: 210 NEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPS 269 ++ +YP++ L ID TM L K+P ++ V++ SNLFGD++SD A + G +G S Sbjct: 236 KQVQKQYPEIALWSTNIDAQTMWLTKNPEEYGVIVASNLFGDVISDAFAGLVGGLGFAAS 295 Query: 270 ASLNEQGFGLYEPAGGSAPDIAGKN--IANPIAQILSLALLLRYSLDADDAACAIERAIN 327 ++ ++ ++EP GSAP A N I NPIA ILS A++L + + + A I +AI Sbjct: 296 GNIGDE-VAVFEPTHGSAPKYAELNPSIVNPIAMILSAAMMLDH-IGESEKADRIRKAIA 353 Query: 328 RALEEG-IRTGDLARGA--------AAVSTDEMGDIIARYVAEGV 363 ++EG +RT D+ R A A +T ++ D I +V + Sbjct: 354 DVVKEGKVRTYDMMRIAGGPKSLAQGAANTVQITDAILVHVETAI 398 >UniRef50_Q5P9Q1 Isocitrate dehydrogenase n=13 Tax=Rickettsiales RepID=Q5P9Q1_ANAMM Length = 488 Score = 307 bits (788), Expect = 3e-82, Method: Composition-based stats. Identities = 94/356 (26%), Positives = 159/356 (44%), Gaps = 30/356 (8%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQP-LPPATVEGC 65 I V GDG+GPE+M L +L R ++ D+G + P+ E Sbjct: 10 ITVAYGDGVGPEIMEAVLFILKEARA----DVSIETVDIGHNQYKKEWTSGIAPSAWESI 65 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 + +L P+ + + LR+ L+ N+RP Y + Sbjct: 66 SRTRLLLKAPTMTPQG-------SGHKSLNVALRQRLGLYVNVRPCVSYFPVVG------ 112 Query: 126 DIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARK 185 D++ +RE Y G E + ++ R E+I AF AR Sbjct: 113 -TKHPDLDVVIIRENEEDTYSG----VEHKLSEDTHECVKISTRSASEKICAYAFNYARA 167 Query: 186 -RRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVL 243 R KVT K N+++ + + +++A YPD+E + +D ++ +P FDV+ Sbjct: 168 HNRKKVTCFVKDNIMKMTDGILHASFDKVAKGYPDIEANYYIVDVGMAKIASNPEDFDVV 227 Query: 244 LCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQIL 303 + +NL+GDI+SD ++ +GS+G+ SA++ + + ++E GSAPDIAGKN+ANP + Sbjct: 228 VTTNLYGDIVSDIVSLSSGSIGLTGSANIGDY-YAMFEAVHGSAPDIAGKNVANPSGLLN 286 Query: 304 SLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAV---STDEMGDIIA 356 + +L + D A I A + LE+G+ T D+ ++ ST E I Sbjct: 287 AAVQMLVHIGQLDKAG-VIRNAFLKTLEDGVHTADIYSEKTSLRRASTMEFAQAIV 341 >UniRef50_A9UQS3 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UQS3_MONBE Length = 378 Score = 307 bits (788), Expect = 3e-82, Method: Composition-based stats. Identities = 102/369 (27%), Positives = 177/369 (47%), Gaps = 32/369 (8%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPAT 61 ++ + + GDGIG E+++ A + ++A + I D+G A+ N G + + Sbjct: 31 TQAHTVLTFDGDGIGREIVSAAKECIEAT----GVNIRWEQMDMGYEAMQNTGVYIDDSH 86 Query: 62 VEGCEQADAVLFGSVGGPKWEH---LPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLE 118 ++ E+ + G + P + + + RK+F+LF+N+RP + G+ Sbjct: 87 MDAFEEIGVLFKGPLTVPPKDTNAYVEVRGKRYTSGNQVFRKYFQLFANVRPVRSMPGVR 146 Query: 119 AFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARI 178 A N D++ +RE T +Y G+ + + + R ER+A Sbjct: 147 APF--------NDVDLVVIRENTEDVYTGEETWVDADTVH----CVKRISRGASERVADF 194 Query: 179 AFESARKR-RHKVTSIDKANVLQ-SSILWREIVNE--IATEYPDVELAHMYIDNATMQLI 234 +F+ AR R +VT++ KANV + S L+ +E AT+ + D+ +L+ Sbjct: 195 SFKYARDNQRKRVTALHKANVCKQSDGLFLNTFHERAAATDLGGIIADDQLADSCLTKLM 254 Query: 235 KDPSQFDVLLCSNLFGDILSDEC----AMITGSMGMLPSASLNEQGFGLYEPAGGSAPDI 290 +P FDVL C NL+GD+++ + GS+G+ PS ++ L+EPA GSAPDI Sbjct: 255 IEPKSFDVLCCPNLYGDLVNPLSLRINRGMVGSLGLCPSGNIGTH-QALFEPAHGSAPDI 313 Query: 291 AGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDE 350 AGK IANP +QILS ++L + L +A+ +E A+ GI D A T E Sbjct: 314 AGKGIANPTSQILSGCMMLSH-LGEFEASQRLENALRAMYASGIVPVDFGGQAD---TKE 369 Query: 351 MGDIIARYV 359 + + +++ Sbjct: 370 VVAAVLKHL 378 >UniRef50_P28834 Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial n=7 Tax=Fungi/Metazoa group RepID=IDH1_YEAST Length = 360 Score = 307 bits (787), Expect = 4e-82, Method: Composition-based stats. Identities = 104/359 (28%), Positives = 177/359 (49%), Gaps = 35/359 (9%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 + + ++PGDG+G E+ + +A + I ++ G VE Sbjct: 28 RFTVTLIPGDGVGKEITDSVRTIFEA----ENIPIDWETINI-KQTDHKEGVY---EAVE 79 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 ++ L G H P DQ + LRK +++N+ K +G++ P Sbjct: 80 SLKRNKIGLKG------LWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRIP- 132 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 D++ +RE T G + G + G E +V R + ERIAR AF+ A Sbjct: 133 -------DIDLIVIRENTEGEFSG-LEHESVPGVVE---SLKVMTRPKTERIARFAFDFA 181 Query: 184 RK-RRHKVTSIDKANVLQ-SSILWREIVNEIA-TEYPDVELAHMYIDNATMQLIKDPSQF 240 +K R VT++ KAN+++ L+R I+ EI EYPD++++ + +DNA+MQ + P QF Sbjct: 182 KKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQF 241 Query: 241 DVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGS-APDIAGKNIANPI 299 DVL+ +++G IL + A + G G++ A+ + ++EP DI G+N+ANP Sbjct: 242 DVLVTPSMYGTILGNIGAALIGGPGLVAGANFGRD-YAVFEPGSRHVGLDIKGQNVANPT 300 Query: 300 AQILSLALLLRYSLDADDAACAIERAINRALEEGIR-TGDLARGAAAVSTDEMGDIIAR 357 A ILS L+L + L ++ A I +A++ + EG T D+ G ++ +TD +II + Sbjct: 301 AMILSSTLMLNH-LGLNEYATRISKAVHETIAEGKHTTRDI--GGSSSTTDFTNEIINK 356 >UniRef50_B1L5I7 Isocitrate dehydrogenase (NAD(+)) n=1 Tax=Candidatus Korarchaeum cryptofilum OPF8 RepID=B1L5I7_KORCO Length = 331 Score = 306 bits (785), Expect = 7e-82, Method: Composition-based stats. Identities = 103/360 (28%), Positives = 172/360 (47%), Gaps = 36/360 (10%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 IAV+ GDG+GPE+M L +L+ G + G+P+ +E Sbjct: 2 RIAVIKGDGVGPEIMGATLSLLERYIGA-----DFIEIKAGKSYFIEEGKPIEDNAIEKI 56 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 + D++L G V P P LR+ FKL++N+RP + Y+G+ Sbjct: 57 RECDSLLKGPVATPTKGPSYP------SVNTLLRREFKLYANVRPFRSYEGIS------- 103 Query: 126 DIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA-R 184 D + VRE +Y+G ++A V + ERI+ AF A R Sbjct: 104 ---IRRIDTILVRENLECLYYGWE-----VEDEDRAIAMRVITKRGAERISEFAFNLAKR 155 Query: 185 KRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVL 243 + R +VT+I K N+L+ + L+ + +A+++ D+ +D A +L+K + FDV+ Sbjct: 156 EGRGRVTAIHKRNILKRTDGLFLDAFYRVASKF-DLRADDEIVDAAGYKLVKLDNAFDVM 214 Query: 244 LCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQIL 303 L NL+GDILSD A + GS+G+ SA + E F +EP G+ DIAGK +ANPI I+ Sbjct: 215 LTPNLYGDILSDVAAGVVGSIGLCGSAQIGED-FAAFEPIHGTGEDIAGKGVANPIGMII 273 Query: 304 SLALLLRYSLD---ADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYVA 360 + +++L + + + I A++ + + I T DL T+++ + I + Sbjct: 274 AASMMLDWLWERGRSPKRGEKIREAVDSVIRDRILTPDLGGD---FRTEQVVEKIVDRLR 330 >UniRef50_C0WN79 Isocitrate dehydrogenase [NADP] n=4 Tax=Lactobacillus RepID=C0WN79_LACBU Length = 429 Score = 304 bits (780), Expect = 3e-81, Method: Composition-based stats. Identities = 100/419 (23%), Positives = 159/419 (37%), Gaps = 72/419 (17%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRF---AMRITTSHYDVGGAAIDNHGQPLP 58 N I + GDGIGPE+ A V DA + ++ G A GQ LP Sbjct: 16 PNNPTIPFIEGDGIGPEIWKAAKTVFDAAVKKAYDGQKQVNWLPLLAGETAYKKTGQWLP 75 Query: 59 PATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLE 118 T+ + + G + P R + LR+ L++ RP Y G Sbjct: 76 DKTLATLREYLVGIKGPLTTPIG-------IGHRSINVTLRQKLDLYACFRPVTYYPGTP 128 Query: 119 AFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYE------------------- 159 + + +I RE T IY G + E Sbjct: 129 SPV-----VHPENVNIDVFRENTEDIYAGIESDVDTKDAEEWKSLLAKQDKLSKVRFPDT 183 Query: 160 KAFDTEVYHRFEIERIARIAFESA-RKRRHKVTSIDKANVLQ-SSILWREIVNEIATEYP 217 AF + + R+ A + A RH +T + K N+++ + +++ E A +Y Sbjct: 184 SAFAIKPISKQGSTRLVDAAIDYAFANNRHTLTLVHKGNIMKKTEGGFKKWGYEAAEKYG 243 Query: 218 D--------------------------------VELAHMYIDNATMQLIKDPSQFDVLLC 245 D + + + DN Q + P F+V+ Sbjct: 244 DKVFTWNQYNQIKADQGEKAADQAYQTARDEQKLIVNDVITDNFFQQALLHPEHFEVVAT 303 Query: 246 SNLFGDILSDECAMITGSMGMLPSASLN-EQGFGLYEPAGGSAPDIAGKNIANPIAQILS 304 NL GD +SD A G +G+ P ++N + G ++E G+AP AG+N NP + ILS Sbjct: 304 MNLNGDYISDALAAQVGGIGIAPGGNINYQTGHAIFEATHGTAPQFAGQNKLNPTSIILS 363 Query: 305 LALLLRYSLDADDAACAIERAINRALEEGIRTGDLAR--GAAAVSTDEMGDIIARYVAE 361 A++ Y L DD + I I RA++ T D A+ A +ST G+ +A+ + E Sbjct: 364 GAMMFDY-LGWDDVSNLIRIGIKRAIKSHHVTVDFAKTPDATVLSTSGFGEYVAQLIEE 421 >UniRef50_Q6GG12 Isocitrate dehydrogenase [NADP] n=90 Tax=root RepID=IDH_STAAR Length = 422 Score = 304 bits (778), Expect = 4e-81, Method: Composition-based stats. Identities = 102/421 (24%), Positives = 170/421 (40%), Gaps = 76/421 (18%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRF---AMRITTSHYDVGGAAIDNHGQPLP 58 I + GDGIGP++ A +V+DA + RI G A D G+ LP Sbjct: 16 PNEPIIPFIIGDGIGPDIWKAASRVIDAAVEKAYNGEKRIEWKEVLAGQKAFDTTGEWLP 75 Query: 59 PATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLE 118 T++ ++ + G + P + R + LR+ LF+ LRP + ++G+ Sbjct: 76 QETLDTIKEYLIAVKGPLTTPIGGGI-------RSLNVALRQELDLFTCLRPVRWFKGVP 128 Query: 119 AFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFD--------------- 163 + D++ RE T IY G + +EG+ + +K D Sbjct: 129 SPV-----KRPQDVDMVIFRENTEDIYAGI-EFKEGTTEVKKVIDFLQNEMGATNIRFPE 182 Query: 164 -----TEVYHRFEIERIARIAFESA-RKRRHKVTSIDKANVLQ-SSILWRE--------- 207 + + ER+ R A + A R VT + K N+++ + +++ Sbjct: 183 TSGIGIKPVSKEGTERLVRAAIQYAIDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLALTE 242 Query: 208 ------------------------IVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVL 243 + E A + + + D Q++ P++ DV+ Sbjct: 243 FGDQVFTWQQYDEIVEKEGRDAANVAQEKAEKEGKIIIKDSIADIFLQQILTRPAEHDVV 302 Query: 244 LCSNLFGDILSDECAMITGSMGMLPSASLN-EQGFGLYEPAGGSAPDIAGKNIANPIAQI 302 NL GD +SD A G +G+ P A++N E G ++E G+AP AG N NP + I Sbjct: 303 ATMNLNGDYISDALAAQVGGIGIAPGANINYETGHAIFEATHGTAPKYAGLNKVNPSSVI 362 Query: 303 LSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLAR---GAAAVSTDEMGDIIARYV 359 LS L+L + L +AA I +I + + T D AR GA VST D + + + Sbjct: 363 LSSVLMLEH-LGWQEAADKITDSIEDTIASKVVTYDFARLMDGAEEVSTSAFADELIKNL 421 Query: 360 A 360 Sbjct: 422 K 422 >UniRef50_C7P3E9 Isocitrate dehydrogenase, NADP-dependent n=5 Tax=Halobacteriaceae RepID=C7P3E9_HALMD Length = 425 Score = 303 bits (777), Expect = 6e-81, Method: Composition-based stats. Identities = 107/410 (26%), Positives = 167/410 (40%), Gaps = 64/410 (15%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPA 60 + +N + ++ GDGIG +V A KVL+A N I+ G +A + + + LP Sbjct: 29 IPENPIVPIIHGDGIGKDVGPAAQKVLEAAANATGREISWMRVFAGESAREKYDENLPDD 88 Query: 61 TVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAF 120 TV ++ + G + P R + LR+ +SN+RP G+ Sbjct: 89 TVNAIDEHRVAIKGPLTTPVGAGF-------RSLNVALRQTLDFYSNVRPTYYLDGVP-- 139 Query: 121 CPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEK-------------------- 160 P++ A D++ RE T +Y G + G+ + E+ Sbjct: 140 SPMK---APEEMDMVTFRENTEDVYAGI-EWEAGTEEVEQVREFVEEDMGFDDVMHDGPI 195 Query: 161 AFDTEVYHRFEIERIARIAFESARKR-RHKVTSIDKANVLQ-SSILWREIVNEIA-TEYP 217 + F +R+ R A + A + R KVT + K N+++ + + E E+A EYP Sbjct: 196 GIGIKPITEFGSKRLVRKAIDYAIEHDRDKVTLVGKGNIMKFTEGQFTEWGMEVADEEYP 255 Query: 218 D-----------------------VELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILS 254 D V + D + +F VL NL GD LS Sbjct: 256 DDEVFAAPDSLWETQDEIDIPEDAVMVESRLADAMLQWMQLRTDEFSVLAMPNLNGDYLS 315 Query: 255 DECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLD 314 D G +G+ P A+ + L EP GSAP AG+N+ANP A ILS L+ Y + Sbjct: 316 DAAGAQIGGLGIAPGANFGDARV-LAEPVHGSAPKRAGQNMANPTAMILSGRLMFDY-MG 373 Query: 315 ADDAACAIERAINRALEEGIRTGDLAR---GAAAVSTDEMGDIIARYVAE 361 DAA + A+ + G T DL R A + T+E D I + + Sbjct: 374 WKDAADLVRDAVEETISSGTVTYDLERQLEDAEKLGTEEYSDAIVENIEK 423 >UniRef50_A6G3V7 Probable 3-isopropylmalate dehydrogenase n=2 Tax=root RepID=A6G3V7_9DELT Length = 368 Score = 303 bits (776), Expect = 7e-81, Method: Composition-based stats. Identities = 112/363 (30%), Positives = 166/363 (45%), Gaps = 25/363 (6%) Query: 20 MTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQ-PLPPATVEGCEQADAVLFGSVGG 78 M + LKVL AV + GG G P + C+ AD +L G+VG Sbjct: 1 MREGLKVLHAVSEPLGIEWAIEDVPCGGQYYLEQGDLDWPSDAPQKCDAADLILLGAVGW 60 Query: 79 PKWEH------LPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEA--FCPLRADIAAN 130 P + ++ ++ R L++N+RP KLY G++ + A Sbjct: 61 PDPAGTGGPVLMKDNKMAGFSPVIGNRMRLNLYANVRPIKLYPGVQHRIHGGHKQIWEAG 120 Query: 131 GFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARKRRH-- 188 D++ +RE T G+Y G+ + A DT V R E++ R AFE ++R Sbjct: 121 KVDMVIIRENTEGLYAPTGGKLAPGGKADVAIDTRVITRRACEQVIRHAFELCKRRNKGA 180 Query: 189 ------KVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDV 242 +VT+I K NVL L+R++ EI EYP++E +D T L+ P +DV Sbjct: 181 PKDGKLRVTAIIKDNVLHGCQLFRDVFFEIGAEYPEIEKDTAIVDAFTQWLVGQPEYYDV 240 Query: 243 LLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQI 302 + SN+FGDI++D + + G MGM ++ + ++EP GSAP AGK+ NPIA I Sbjct: 241 CVTSNMFGDIVTDLASTLQGGMGMAVGGNIGKHN-AMFEPIHGSAPKHAGKDKVNPIAMI 299 Query: 303 LSLALLLRYSLDADDAACA------IERAINRALEEG-IRTGDLARGAAAVSTDEMGDII 355 LS+ L + D A IE A+ LE+G T DL A E+G I Sbjct: 300 LSVKEGLEWLAARKDDATLTKAAEAIEAAVVEVLEKGETLTYDLVGNDRASKCSEVGSAI 359 Query: 356 ARY 358 A Sbjct: 360 AEA 362 >UniRef50_O43837 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial n=80 Tax=Eumetazoa RepID=IDH3B_HUMAN Length = 385 Score = 303 bits (776), Expect = 8e-81, Method: Composition-based stats. Identities = 93/361 (25%), Positives = 164/361 (45%), Gaps = 26/361 (7%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 ++ + +LPGDG+GPE+M +V A A+ + + + + L + Sbjct: 48 SFPVTMLPGDGVGPELMHAVKEVFKAA----AVPVEFQEHHLSEVQNMASEEKL-EQVLS 102 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 ++ + G + P + + LR+ LF+N+ K G Sbjct: 103 SMKENKVAIIGKIHTP-----MEYKGELASYDMRLRRKLDLFANVVHVKSLPGYMT---- 153 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 N D++ +RE T G Y + G E ++ R + +RIA+ AF+ A Sbjct: 154 ----RHNNLDLVIIREQTEGEYSS-LEHESARGVIE---CLKIVTRAKSQRIAKFAFDYA 205 Query: 184 -RKRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFD 241 +K R KVT++ KAN+++ L+ + E+A YP ++ M IDN MQL+++P QFD Sbjct: 206 TKKGRGKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFD 265 Query: 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQ 301 VL+ NL+G+I+ + A + G G++P S + + A G+NIANP A Sbjct: 266 VLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEYAVFETGARHPFAQAVGRNIANPTAM 325 Query: 302 ILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYVAE 361 +LS + +LR+ ++ + +RT D+ G + +TD + +I + Sbjct: 326 LLSASNMLRHLNLEYHSSMIADAVKKVIKVGKVRTRDM--GGYSTTTDFIKSVIGHLQTK 383 Query: 362 G 362 G Sbjct: 384 G 384 >UniRef50_Q48806 Protein dlpA n=5 Tax=Legionella RepID=DLPA_LEGPH Length = 615 Score = 302 bits (775), Expect = 9e-81, Method: Composition-based stats. Identities = 104/381 (27%), Positives = 171/381 (44%), Gaps = 47/381 (12%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 IAVLPGDGIG EV L V + + + + ++ D+G G +P T + Sbjct: 8 KIAVLPGDGIGIEVTEATLPVFEVL----DVPVILNYGDIGWEFWKKEGAAIPSRTWQLI 63 Query: 66 EQADAVLFGSVGGPKWEH--------LPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGL 117 +D VL G++ L ++ LR+ LF+N+RP Sbjct: 64 ASSDTVLLGAITSKPQREAKQELSNALKKSNPYYVSPVIQLRQGLDLFANVRPCFSI--- 120 Query: 118 EAFCPLRADIAANGFDILCVRELTGGIYFG---------------QPKGREGSGQYEKAF 162 D + F+ +RE + G+Y G + + + E + Sbjct: 121 --------DDQSKPFNFCIIRENSEGLYCGFDYFPLPKAIHSLLAESQHWQTIPADEASC 172 Query: 163 DTEVYHRFEIERIARIAFESARKRR-HKVTSIDKANVLQSSILW-REIVNEIATEYPDVE 220 + + + R+ AF+ A + +VT DK NVL+ S + R+I A YP ++ Sbjct: 173 ALRLQSKSGLTRLFDFAFKHAMQTGMPRVTLADKPNVLRESGEFTRKIFESTAQRYPKIQ 232 Query: 221 LAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLY 280 + +D + LIK P +F V++ N+FGDILSD A + G +G+ PSA++ ++G + Sbjct: 233 ADILNVDAVALWLIKSPEKFGVIVAENMFGDILSDVGAGVMGGLGLAPSANIGDKG-SYF 291 Query: 281 EPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEG-IRTGDL 339 EP GS P I KN ANP A L++++LL + D A I A+ + ++E T DL Sbjct: 292 EPVHGSGPRIR-KNCANPSAMFLTISMLLNH-FGYPDRAKKIVNAVMQVIKEKRFITYDL 349 Query: 340 ARGAAAVSTDEMGDIIARYVA 360 +T +M + + + A Sbjct: 350 ---GGHATTTDMANAVIEHCA 367 >UniRef50_Q0ZQ44 FrbE n=1 Tax=Streptomyces rubellomurinus RepID=Q0ZQ44_9ACTO Length = 365 Score = 302 bits (775), Expect = 1e-80, Method: Composition-based stats. Identities = 105/378 (27%), Positives = 167/378 (44%), Gaps = 37/378 (9%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATV 62 + + + ++ GDG GPE++ A VLD + G A+ + G+ LP +T+ Sbjct: 2 RKHTVTLIAGDGSGPELVAAARTVLDTAAGSAGFHLDWDVRPAGQGALRSVGELLPASTL 61 Query: 63 EGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 + + L G P R + +R+ L++ +RP +++ G Sbjct: 62 DSIRRNGVALKGPTTTPIG-------VGHRSVNITIRRELDLYACVRPVRVWPG------ 108 Query: 123 LRADIAANGFDILCVRELTGGIYFGQPKGREGSGQY--------------EKAFDTEVYH 168 A +G D++ VRE T +Y G + G AF + Sbjct: 109 --AGAVDSGIDVVVVRENTEDVYSGLEYPADSDGAAVVSATLSEFGHADPGIAFSLKPIT 166 Query: 169 RFEIERIARIAFESARK--RRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYI 226 RI A + ARK RR D ++ L+ E E+ EYPD+ A + + Sbjct: 167 PGGSRRIVAFALDHARKNGRRKVEVGADVYRYPRTEGLFFEAARELGPEYPDIVTATVPV 226 Query: 227 DNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGS 286 L++DP+ DVL+ NL+GD++SD A + G +GM P A++ ++ ++E GS Sbjct: 227 TVLCDSLVRDPADRDVLVLPNLYGDVISDVTAALVGGLGMAPGANIGDR-TAVFEATHGS 285 Query: 287 APDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEG-IRTGDLA---RG 342 AP+ AG N NP A ILS +LL + +A AA I A+ LEEG T DL R Sbjct: 286 APEFAGSNRLNPTALILSGCMLLDHLGEAPTAA-RIRAAVRSVLEEGRSVTFDLLPPDRA 344 Query: 343 AAAVSTDEMGDIIARYVA 360 A AV+T + + + Sbjct: 345 ARAVTTTAYAEAVIERLR 362 >UniRef50_O67480 Isocitrate dehydrogenase [NADP] n=5 Tax=Aquificales RepID=IDH_AQUAE Length = 426 Score = 300 bits (769), Expect = 5e-80, Method: Composition-based stats. Identities = 105/406 (25%), Positives = 172/406 (42%), Gaps = 62/406 (15%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRF---AMRITTSHYDVGGAAIDNHGQPLP 58 N I + GDGIGPE+ L +++ + + +I G A + G+ LP Sbjct: 36 PDNPIIPFIEGDGIGPEITQAMLLIINTAVEKTYNGSKKIYWVELLAGDKAEEKTGERLP 95 Query: 59 PATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLE 118 T++ +++ + G +G P + + R LR+ F +S +RP + G Sbjct: 96 QETLDVLKESIVGIKGPLGTPVGKGV-------RSINSALRRAFDYYSAVRPV-YWMGQA 147 Query: 119 AFCPLRADIAANGFDILCVRELTGGIYFG-------------------QPKGREGSGQYE 159 P D++ RE T +Y G + +E + Sbjct: 148 TPIP-----NPERVDLVVFRENTDDVYAGVEFFAGTPEAKKVREFLIKEMGAKEEGFPED 202 Query: 160 KAFDTEVYHRFEIERIARIAFESARKRRHK-VTSIDKANVLQ-SSILWREIVNEIATEYP 217 + F+ +R R A A + K V I K N+++ + + E+A E Sbjct: 203 VGITVKPMSEFKTKRHVRKALRYALENNKKNVAVIGKGNIMKATEGAFINWAFEVAEEPE 262 Query: 218 ----------------DVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMIT 261 V+L + D MQL+ P +DV++ NL GD +SD A + Sbjct: 263 FKGKVVTDPEAEPGEGQVKLTKVITDQMLMQLVLKPEAWDVIIAQNLNGDYVSDLAASLI 322 Query: 262 GSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACA 321 G G +PS ++ + G+ L+E G+A DIAGK IANP++ LS A++L Y + +AA Sbjct: 323 GGPGFVPSGNIGD-GYALFESTHGTAWDIAGKGIANPLSLTLSGAMMLEY-IGWKEAAQK 380 Query: 322 IERAINRALEEGIRTGDLARG-------AAAVSTDEMGDIIARYVA 360 + A+ R L E I T D+A G A AV T E + I++ + Sbjct: 381 VYDAVRRTLAEHIGTPDIASGFQKQGIEAKAVGTMEFAEEISKRIE 426 >UniRef50_P96318 Isocitrate dehydrogenase [NADP] n=5 Tax=cellular organisms RepID=IDH_CALNO Length = 429 Score = 299 bits (765), Expect = 2e-79, Method: Composition-based stats. Identities = 106/404 (26%), Positives = 162/404 (40%), Gaps = 59/404 (14%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRF---AMRITTSHYDVGGAAIDNHGQPLP 58 N +A GDGIGPE++ A KVLDA ++ RI G A G LP Sbjct: 30 PDNLIVAYFKGDGIGPEIVESAKKVLDAAVDKAYGGTRRIVWWEVTAGEEAQKECGSLLP 89 Query: 59 PATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLE 118 T++ + A L G + P R + LR L+SN+RP K Y G Sbjct: 90 DGTLQAFKLARVNLKGPLTTPVGGGF-------RSLNVTLRMVLDLYSNVRPVKWY-GQP 141 Query: 119 AFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQY----------------EKAF 162 D + RE T +Y G + + Sbjct: 142 T-----PHCHPENIDWVIFRENTEDVYAGIEWPFDSPEAQKIRDFLKKEFGIELTPDTGI 196 Query: 163 DTEVYHRFEIERIARIAFESARKRR-HKVTSIDKANVLQ-SSILWREIV----------- 209 + ++ +R R A E A + VT + K N+++ + +R+ Sbjct: 197 GIKPISKWRTQRHVRRAMEWAIRNGYKHVTIMHKGNIMKYTEGAFRQWAYDLILSEFRDY 256 Query: 210 ----NEIATEYPD------VELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAM 259 E+ T+Y + + DN Q+I P +++V++ NL GD +SDE Sbjct: 257 VVTEEEVNTKYGGKAPEGKIIVNDRIADNMLQQIITRPGEYNVIVTPNLNGDYISDEANA 316 Query: 260 ITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAA 319 + G +GM + + G + EP GSAP AGKN+ NP A+ILS LL + + Sbjct: 317 LVGGIGMAAGLDMGD-GIAVAEPVHGSAPKYAGKNVINPTAEILSGMYLLSDFVGWPEVK 375 Query: 320 CAIERAINRALEEGIRTGDLAR---GAAAVSTDEMGDIIARYVA 360 +E A+ +A+ T DLAR G +ST E D++ Y+ Sbjct: 376 LLVEYAVKQAIAHKQVTYDLAREMGGVTPISTTEYTDVLVDYIR 419 >UniRef50_UPI00019260EC PREDICTED: similar to predicted protein isoform 1 n=4 Tax=Hydra magnipapillata RepID=UPI00019260EC Length = 389 Score = 297 bits (762), Expect = 3e-79, Method: Composition-based stats. Identities = 89/360 (24%), Positives = 156/360 (43%), Gaps = 31/360 (8%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 + ++++P DGIG ++ ++V + + + G + + Sbjct: 45 RHTVSLIPADGIGQSLIMGIVEVFQ----NSGVPVDFEECYITGDTNEEKMKSF-NDIKT 99 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 + L G+ + + LR L++N+ K Y + Sbjct: 100 SVLRNGTALKGNWAT-------SMGIDSKSYNVLLRHDLDLYANVVKFKSYPTVIT---- 148 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 N D++ +RE T G Y + G E ++ + + ERIA+ AF+ A Sbjct: 149 ----RHNNVDLIVIRENTEGEYT-NLEHENIPGVIEM---IKIITKKKSERIAKYAFDYA 200 Query: 184 R-KRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFD 241 R KVT++ KAN+++ S L+ ++ E+A YP+++ M IDN MQ++ P QFD Sbjct: 201 MENNRKKVTAVHKANIMKLSDGLFLKVCKEVAEGYPEIDFNDMIIDNCAMQMVSKPEQFD 260 Query: 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQ 301 V++ NL+G++LS+ A + G G+ + S DIA KNIANP++ Sbjct: 261 VIVTPNLYGNVLSNIAAALVGGPGLPHGENHGNGIHVFESGTRNSGMDIATKNIANPMSM 320 Query: 302 ILSLALLLRYSLDADDAACAIERAINRALEEG-IRTGDLARGAAAVSTDEMGDIIARYVA 360 + + LLR+ L A IE I++ + RT D+ ST E +I+ + V Sbjct: 321 LFAATALLRH-LQLSKHAQLIESCIHKIVTTNQARTVDI---GGNTSTSEFFEILVKEVE 376 >UniRef50_Q9U6V3 Isocitrate dehydrogenase gamma subunit n=4 Tax=Bilateria RepID=Q9U6V3_9BILA Length = 388 Score = 297 bits (760), Expect = 5e-79, Method: Composition-based stats. Identities = 91/367 (24%), Positives = 169/367 (46%), Gaps = 42/367 (11%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPAT-- 61 + + +LPGDGIGPE++ K+ T ++ V +P P + Sbjct: 44 RHTVTLLPGDGIGPEMLDIVQKI-----------FTFANVPVDFEECQLDSKPTSPESDL 92 Query: 62 ---VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLE 118 + ++ + G++ + + + + LR+ LF+N+ + Sbjct: 93 DNAIMSIQRNGVAIKGNIETKYDDPIF------KSRNVELRRRLDLFANVLHCVSIPTIP 146 Query: 119 AFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARI 178 G +I+ +RE T G Y G + +G E ++ R ++ERI+R Sbjct: 147 T--------RHKGINIVMIRENTEGEYSG-HEHETVNGVVE---SLKICTREKLERISRF 194 Query: 179 AFESA-RKRRHKVTSIDKANVLQ-SSILWREIVNEIA-TEYPDVELAHMYIDNATMQLIK 235 AF+ A R K+T++ KAN+ + + L+ ++V EIA EYP + M +DNA+MQL+ Sbjct: 195 AFDYAIAHNRKKITAVHKANIQKLADGLFLKVVGEIAEKEYPSITFDSMIVDNASMQLVS 254 Query: 236 DPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNI 295 P QFD++L NL+G+I+S+ + G G++ ++ ++ + IAG++I Sbjct: 255 RPQQFDIMLMPNLYGNIISNIACGLVGGPGLVSGMNIGDKYAVFETGTRNTGSGIAGQDI 314 Query: 296 ANPIAQILSLALLLRYSLDADDAACAIERAINRALE-EGIRTGDLARGAAAVSTDEMGDI 354 ANP A I + +L + L + A I A+ A+ + + T D+ A T ++ + Sbjct: 315 ANPTAFIRAGVDML-HYLGLTEYANLISDALFDAIVIKRLHTKDIGGTAK---TSDVVNA 370 Query: 355 IARYVAE 361 + R + Sbjct: 371 VMRNIES 377 >UniRef50_A0P1S6 3-isopropylmalate dehydrogenase n=3 Tax=Rhodobacterales RepID=A0P1S6_9RHOB Length = 369 Score = 292 bits (748), Expect = 1e-77, Method: Composition-based stats. Identities = 117/367 (31%), Positives = 172/367 (46%), Gaps = 18/367 (4%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRI-TTSHYDVGGAAIDNHGQPLPPATVEG 64 IA++ GDGIG +V A+ VL+ G G + E Sbjct: 2 KIALIKGDGIGVDVAEAAIAVLETALKHTGEPAPRYDEIQAGAGYFKETGLDIEDGGEER 61 Query: 65 CEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 ADA+ G++G P H E L LR F L++ +RP K Y Sbjct: 62 AGLADAIFLGAIGLPSIRHA---NGTEISPHLRLRDRFGLYAGVRPVKAYPNAPQ---RL 115 Query: 125 ADIAANGFDILCVRELTGGI-YFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 AD A G D++ +RE T G+ Y R ++ D R ++ R AF A Sbjct: 116 ADPRAAGIDLVILRESTEGLFYSAAAHKRSLVVNDDEVQDVLRITRKTTTKLHRFAFNLA 175 Query: 184 RKRR-----HKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPS 238 RKRR ++T +DKANV S +R+I +E+ +E+ DV + + Y+D + L++ P Sbjct: 176 RKRRERGHPGRLTCVDKANVFTSLAFFRQIFDEVKSEFADVPVGYNYVDAQALDLVRKPW 235 Query: 239 QFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANP 298 +FDVL+ N+FGDILSD + G MGM + + GL++PA GSAPDI G++ ANP Sbjct: 236 EFDVLVMENMFGDILSDLAGGLVGGMGMAACGEIGDT-TGLFQPAHGSAPDIMGEDKANP 294 Query: 299 IAQILSLALLLRYSLDADDAACAIERA--INRALEEGIRTGDLA--RGAAAVSTDEMGDI 354 +A ILS AL+L Y + D + A I+ A+E G L + T + Sbjct: 295 LAAILSAALMLDYLAEKLDKPSLADAAELIDSAVETGFWHNALRPIEFGGDMGTRAVTKE 354 Query: 355 IARYVAE 361 + VA+ Sbjct: 355 LLGRVAQ 361 >UniRef50_A4WLX6 Isocitrate dehydrogenase (NADP) n=22 Tax=Archaea RepID=A4WLX6_PYRAR Length = 439 Score = 291 bits (746), Expect = 2e-77, Method: Composition-based stats. Identities = 111/405 (27%), Positives = 168/405 (41%), Gaps = 65/405 (16%) Query: 7 IAVLPGDGIGPEVMTQALKVL-DAVRNRFA--MRITTSHYDVGGAAIDNHGQPLPPATVE 63 I + GDGIGPEV A+KV +AV + +IT VG A G LP ++E Sbjct: 47 IGYIEGDGIGPEVAYAAIKVANEAVEKAYGKSRQITWYEIVVGEKAEKLFGNRLPDQSIE 106 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 + L + P R + LR+ F L++N+RP K + GL PL Sbjct: 107 VLRKIRVFLKAPLETPVGGGF-------RSINVTLRQLFDLYANIRPVKYFPGLP--SPL 157 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQ----------------YEKAFDTEVY 167 R D++ RE T +Y G + + Sbjct: 158 R---RPELVDLVIFRENTEDVYAGIEWPYNSPEAAKIREFLRREFGVNIRDDAGIGIKPI 214 Query: 168 HRFEIERIARIAFESARKRRHKV-TSIDKANVLQ-SSILWREIVNEIAT----------- 214 +F +RIAR+A + A + + +V T + K N+ + + ++E E+A Sbjct: 215 SKFGTQRIARLALKFAIENKRRVVTVMHKGNIQKYTEGAFKEWAFEVARNEFREHVVFED 274 Query: 215 ---EYPD------VELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMG 265 +Y V + DN QL+ ++DV+L NL GD +SDE A + G +G Sbjct: 275 ELAQYGGSVPPGKVLVNDRIADNMLQQLLTRTGEYDVILAPNLNGDYVSDEAAGLVGGLG 334 Query: 266 MLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERA 325 + P + + G + EP G+AP GKN NP A IL+L L+ R+ L + A I + Sbjct: 335 VAPGLDVGDWG-MMAEPVHGTAPKYRGKNYVNPTATILALELMFRF-LGWREVAEYIMKG 392 Query: 326 INRALEEGIRTGDLARG----------AAAVSTDEMGDIIARYVA 360 + A EG TGDLAR + T E D + + Sbjct: 393 VETAYREGYFTGDLARQMTDEERKMRVKEVLGTQEFADKVVEIIK 437 >UniRef50_B7UV18 Isocitrate dehydrogenase [NADP] n=9 Tax=Gammaproteobacteria RepID=B7UV18_PSEA8 Length = 418 Score = 291 bits (745), Expect = 3e-77, Method: Composition-based stats. Identities = 94/408 (23%), Positives = 166/408 (40%), Gaps = 65/408 (15%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRF---AMRITTSHYDVGGAAID--NHGQP 56 KN I + GDGIG ++ +KV+DA + +I G A + Sbjct: 26 PKNPIIPFIEGDGIGVDISPVMIKVVDAAVEKAYKGERKIAWMEVYAGEKATQVYDQDTW 85 Query: 57 LPPATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQG 116 LP T++ + G + P + R + LR+ L+ RP + ++G Sbjct: 86 LPQETLDAVRDYVVSIKGPLTTPVGGGI-------RSLNVALRQQLDLYVCQRPVRWFEG 138 Query: 117 LEAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFD------------- 163 + + D++ RE + IY G + + GS + EK Sbjct: 139 VPSPV-----KKPGDVDMVIFRENSEDIYAG-VEWKAGSPEAEKVIKFLTEEMGVKKIRF 192 Query: 164 -------TEVYHRFEIERIARIAFESARKR-RHKVTSIDKANVLQ-SSILWREIVNEIAT 214 + + +R+ R A + A R VT + K N+++ + +++ E+A Sbjct: 193 TENCGIGIKPVSQEGTKRLVRKALQYAVDNDRSSVTLVHKGNIMKFTEGAFKDWGYEVAR 252 Query: 215 EY--------------------PDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILS 254 + +V + + D Q++ P+++DV+ NL GD LS Sbjct: 253 DEFGAELLDGGPWMQFKNPKTGKNVVVKDVIADAMLQQILLRPAEYDVIATLNLNGDYLS 312 Query: 255 DECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLD 314 D A G +G+ P A+L++ ++E G+AP AG++ NP + ILS ++LR+ + Sbjct: 313 DALAAEVGGIGIAPGANLSDS-VAMFEATHGTAPKYAGQDKVNPGSLILSAEMMLRH-MG 370 Query: 315 ADDAACAIERAINRALEEGIRTGDLAR---GAAAVSTDEMGDIIARYV 359 +AA I + N A+ T D R GA +S E GD + + Sbjct: 371 WTEAADLIIKGTNGAIAAKTVTYDFERLMDGATLLSCSEFGDAMIAKM 418 >UniRef50_A9A2N6 Isocitrate dehydrogenase (NAD(+)) n=11 Tax=Archaea RepID=A9A2N6_NITMS Length = 343 Score = 285 bits (731), Expect = 1e-75, Method: Composition-based stats. Identities = 114/373 (30%), Positives = 172/373 (46%), Gaps = 42/373 (11%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHG----QP 56 MSK AV+ GDGIGPEV+ L+VL + + + + G D +G Sbjct: 1 MSK--KAAVMKGDGIGPEVVDSMLRVLKECNFQSELILC----EAGSEQWDKNGRKDASY 54 Query: 57 LPPATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQG 116 +P T++ E+ D G P R + LR+ F L++N+RP K Y Sbjct: 55 IPDVTMKILEETDCCFKGPTTTIPVPGAP------RSVAVTLRQKFDLYANIRPTKTYDR 108 Query: 117 LEAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIA 176 L D +C RE T G+Y G E + A R R+ Sbjct: 109 L---------TPDRKLDCVCFREATEGLYTG----VEAKITDDAAIAIRKITRQGSRRLI 155 Query: 177 RIAFESARK-RRHKVTSIDKANVLQSSI--LWREIVNEIATEYPDVELAHMYIDNATMQL 233 A + A K K+ ++ K N+L+ + W E + E D+EL+ +YIDN Q+ Sbjct: 156 DSAVDWANKFNMKKMVAVTKRNILKQTDGIFWDETQKAV--EGTDIELSEIYIDNMAQQM 213 Query: 234 IKDPSQFD--VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIA 291 + QF+ VL+ +NLF DI+S+ + + GS+G++ SA++ + + ++E A GSAP A Sbjct: 214 VIATEQFNGAVLVSTNLFMDIISELASALVGSIGLIYSANIGDN-YAMFEAAHGSAPQFA 272 Query: 292 GKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGI-RTGDLARGAAAVSTDE 350 G+N NP A +LS A + Y L D AI A + + EG T D+ A ST + Sbjct: 273 GQNKVNPTATVLSGAWMADY-LGERDVRDAIFAATEQVINEGKAVTWDIGGDA---STTQ 328 Query: 351 MGDIIARYVAEGV 363 M D I Y E + Sbjct: 329 MTDAIITYAKEKL 341 >UniRef50_Q0A635 Isocitrate/isopropylmalate dehydrogenase n=1 Tax=Alkalilimnicola ehrlichii MLHE-1 RepID=Q0A635_ALHEH Length = 382 Score = 284 bits (727), Expect = 4e-75, Method: Composition-based stats. Identities = 130/366 (35%), Positives = 183/366 (50%), Gaps = 23/366 (6%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITT-SHYDVGGAAIDNHGQPLPPAT 61 + + + VLPG+G+GPEV+ AL +L + R + +G A G+ L P Sbjct: 26 EAFLVGVLPGEGVGPEVIDVALSLLRLLGEATGQRFEVRTGGPIGRQAERLTGRGLTPEV 85 Query: 62 VEGCEQA----DAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGL 117 + C Q AVL G GG + LR+HF L+ L P + + L Sbjct: 86 RDFCAQVFAQGGAVLCGPGGGR--------------FVYDLRRHFDLYCKLIPLRHWPAL 131 Query: 118 EAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIAR 177 LR + AA D+L VRE G+Y G+ G EG G A+ Y E+ERI R Sbjct: 132 ADAGVLRPE-AARSADVLIVRENASGLYCGE-WGSEGEGAARSAYQVCRYRADEVERILR 189 Query: 178 IAFESARKRRHKVTSIDK-ANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKD 236 A A +RR + + K V S LW + + +A E+ V + +DNA QLI D Sbjct: 190 TALRLAGQRRGDLVVVTKPGGVPAISALWHDALTAVAGEHGAVRCRTLEVDNAAYQLIAD 249 Query: 237 PSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIA 296 P QFDV++C N+FGDIL D +++ GS GM S + G +Y+ A G+A D+AG++ A Sbjct: 250 PRQFDVIVCPNMFGDILGDCGSLLMGSRGMSWSGNYGAAGQAVYQTAHGAAWDLAGRDRA 309 Query: 297 NPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGA-AAVSTDEMGDII 355 NPI Q+ SLA++LR S A A+E AI R L G+RT D+ AV T MG + Sbjct: 310 NPIGQVCSLAMMLRESFRLPALADALETAIARTLARGVRTADIQGAQPTAVGTRAMGQAL 369 Query: 356 ARYVAE 361 + E Sbjct: 370 CASLTE 375 >UniRef50_Q9ZN36 Isocitrate dehydrogenase [NADP] n=932 Tax=root RepID=IDH_HELPJ Length = 425 Score = 282 bits (723), Expect = 1e-74, Method: Composition-based stats. Identities = 97/410 (23%), Positives = 165/410 (40%), Gaps = 73/410 (17%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAV---RNRFAMRITTSHYDVGGAAIDNH---------G 54 I + GDGIG ++ +KV+D+ + +I VG Sbjct: 32 IPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIAWYEVFVGEKCYQKFKDHKELSPEE 91 Query: 55 QPLPPATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLY 114 Q L P T+E + G + P E R + LR+ L+ LRP + Y Sbjct: 92 QWLLPDTIEAINHYKVSIKGPLTTPIGEGF-------RSLNVALRQKMDLYVCLRPVRWY 144 Query: 115 QGLEAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEK-------------- 160 + P++ D++ RE + IY G + +EGS + +K Sbjct: 145 ---GSPSPVKE---PQKVDMVIFRENSEDIYAGI-EWQEGSAEAKKLIHFLQNELKVEKI 197 Query: 161 ------AFDTEVYHRFEIERIARIAFESARKRRH-KVTSIDKANVLQ-SSILWREIVNEI 212 + + ER+ R A E A VT + K N+++ + + + + Sbjct: 198 RFPESSGVGIKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYTEGAFMKWGYAL 257 Query: 213 A-TEY-------------------PDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDI 252 A E+ ++ + M D Q++ PS++ V+ NL GD Sbjct: 258 AQKEFNAQVIDKGPWCSLKNPKTGKEIIIKDMIADAFLQQILLRPSEYSVIATMNLNGDY 317 Query: 253 LSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYS 312 +SD A + G +G+ P A+LN+ G++E G+AP AG + NP + ILS ++LR+ Sbjct: 318 ISDALAAMVGGIGIAPGANLNDT-VGMFEATHGTAPKYAGLDKVNPGSIILSAEMMLRH- 375 Query: 313 LDADDAACAIERAINRALEEGIRTGDLAR---GAAAVSTDEMGDIIARYV 359 + +AA I A+ +A++ T D AR GA V E ++ + Sbjct: 376 MGWVEAADLIVSAMEKAIKSKKVTYDFARLMDGAKEVKCSEFASVMIENM 425 >UniRef50_P41560 Isocitrate dehydrogenase [NADP] 1 n=78 Tax=cellular organisms RepID=IDH1_COLMA Length = 415 Score = 279 bits (713), Expect = 2e-73, Method: Composition-based stats. Identities = 88/408 (21%), Positives = 162/408 (39%), Gaps = 66/408 (16%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRF---AMRITTSHYDVGGAAIDNHG--QP 56 N I + GDGIG +V LKV++A + +I G A + Sbjct: 24 PNNPIIPYIEGDGIGVDVTPPMLKVVNAAVAKAYGGDRKIEWLEVYAGEKATKMYDSETW 83 Query: 57 LPPATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQG 116 LP T+ ++ + G + P + + +R+ L+ RP + + G Sbjct: 84 LPEETLNILQEYKVSIKGPLTTPVGGGMS-------SLNVAIRQMLDLYVCQRPVQWFTG 136 Query: 117 LEAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFD------------- 163 + + + D++ RE T IY G + + GS + + Sbjct: 137 VPSPV-----KRPSEVDMVIFRENTEDIYAGI-EYKAGSDKAKSVIKFLIEEMGASNIRF 190 Query: 164 -------TEVYHRFEIERIARIAFESA-RKRRHKVTSIDKANVLQ-SSILWREIVNEIAT 214 + + +R+ R A + A + VT + K N+++ + +++ E+A Sbjct: 191 TENCGIGIKPVSKEGSQRLVRQAIQYAIDNNKDSVTLVHKGNIMKFTEGAFKDWGYELAI 250 Query: 215 EY--------------------PDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILS 254 E ++ + + D Q++ P+++ V+ NL GD LS Sbjct: 251 EEFGASLLHGGPWCSLKNPNTGKEIIIKDVIADAMLQQVLLRPAEYSVIATLNLNGDYLS 310 Query: 255 DECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLD 314 D A G +G+ P A+L ++ ++E G+AP AGKN NP + ILS ++LR+ Sbjct: 311 DALAAQVGGIGIAPGANLGDE-VAVFEATHGTAPKYAGKNKVNPGSVILSAEMMLRHMGW 369 Query: 315 ADDAACAIERAINRALEEGIRTGDLAR---GAAAVSTDEMGDIIARYV 359 + A + + ++ A++ T D R A VS GD I ++ Sbjct: 370 LE--ADLLLKGMSGAIQAKTVTYDFERLMDDATLVSCSAFGDCIIDHM 415 >UniRef50_A1WV93 3-isopropylmalate dehydrogenase n=8 Tax=Gammaproteobacteria RepID=A1WV93_HALHL Length = 389 Score = 278 bits (712), Expect = 2e-73, Method: Composition-based stats. Identities = 126/387 (32%), Positives = 179/387 (46%), Gaps = 39/387 (10%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATV 62 +++ +AV+PGDGIGPEVM L+A+ A+ +T + D HG+ +P Sbjct: 6 ESWQVAVMPGDGIGPEVMAATRHALEALPGP-ALVLTELGWPAHAWHRD-HGEMMPADWR 63 Query: 63 EGCEQADAVLFGSVGGPKWEHLP-----PDQQPERGALLPLRKHFKLFSNLRPAKLYQGL 117 DA+L G++G P H PD LL LRK L++ RPA G Sbjct: 64 GQLAGYDALLLGALGDPGPSHDAQRYCLPDGVSL-APLLQLRKGLDLWACERPAVPLAGA 122 Query: 118 EAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIAR 177 +D A D+L +RE + G Y Q E A EV+ R ERI R Sbjct: 123 PMPL---SDPRALHTDLLVIRENSEGEYVDQGGRLAAGTPRETATQLEVFTRAGTERIIR 179 Query: 178 IAFESA-----------RKRRHK---------VTSIDKAN-VLQSSILWREIVNEIATEY 216 AFE A R R+ V + K N V + LW E+ E+A EY Sbjct: 180 HAFERAARRAEERRQGLRAPRYAAADGAADAAVCVVTKRNAVQYAGELWSEVFAEVAAEY 239 Query: 217 PDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQG 276 P + H ID M+ + P QFDV++ SNL GDIL+D A++ G MG+ PSA+LN Sbjct: 240 PGIATHHELIDACCMKFVSQPWQFDVVVASNLHGDILTDLAAVLAGGMGVAPSANLNPAD 299 Query: 277 FGL---YEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEG 333 + +EP GSAPDIAG + A+P A +L+ A +L + + D A + RA+ E Sbjct: 300 RSVPPLFEPTHGSAPDIAGADRAHPAAMLLTAAAMLEWMGEVDPVAARSAVQLQRAVAED 359 Query: 334 IRTGDLARGAAAVSTDEMGDIIARYVA 360 I + E+G +A+ + Sbjct: 360 IAEHGMGGRG----CAEVGRAVAQRIR 382 >UniRef50_Q18GT1 3-isopropylmalate dehydrogenase n=8 Tax=Halobacteriaceae RepID=Q18GT1_HALWD Length = 334 Score = 277 bits (708), Expect = 5e-73, Method: Composition-based stats. Identities = 124/363 (34%), Positives = 182/363 (50%), Gaps = 36/363 (9%) Query: 1 MSK--NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLP 58 MS+ + I V+ GDGIG EV+ A+ VL AV + + + G D G LP Sbjct: 1 MSRGGEHEIVVIEGDGIGQEVIPAAVAVLQAVD---EVGFSFTEKQAGDDTRDQTGAALP 57 Query: 59 PATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLE 118 T E ADA LFG+ G + +LPLR+ F N+RPA+ Y G++ Sbjct: 58 ETTYEAAADADATLFGAAG-----------ETAADVILPLREAVGSFVNIRPARAYPGVD 106 Query: 119 AFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARI 178 A P D++ +RE T G+Y G E + + T V E++A Sbjct: 107 ALQP--------ETDLVFLRENTEGVYSGH----EDRLSEDLSTLTRVITTSASEQLAEY 154 Query: 179 AFESARKRR-HKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKD 236 A +R ++ KANV+Q + +R+ V+ +A DV + +D ++ + Sbjct: 155 ACSYVTERSIDGFHTVHKANVMQETDGRFRDAVSRVAAS-NDVATNEVLMDAFATRVCLN 213 Query: 237 PSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIA 296 P+QFDV++C NL GD+LSD A + G +G+LPSA++ Q L+EP G+APDIAG IA Sbjct: 214 PTQFDVVVCPNLAGDVLSDLAAGLVGGLGLLPSANIG-QTNALFEPVHGTAPDIAGDGIA 272 Query: 297 NPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIA 356 NP A ILS +LL Y L DAA ++ A+ L G RT DL A ST+ + + + Sbjct: 273 NPSASILSAGMLLEY-LGETDAATNVQMAVESVLNSGPRTPDLGGNA---STEAVVNAVI 328 Query: 357 RYV 359 + Sbjct: 329 EQL 331 >UniRef50_Q3IKZ8 Isocitrate dehydrogenase, specific for NADP+ n=3 Tax=Alteromonadales RepID=Q3IKZ8_PSEHT Length = 419 Score = 276 bits (707), Expect = 8e-73, Method: Composition-based stats. Identities = 100/406 (24%), Positives = 164/406 (40%), Gaps = 63/406 (15%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNR---FAMRITTSHYDVGGAAIDNH-GQP 56 + IA + GDG+G +VM KV+D+ +I G A + G Sbjct: 28 IPLQPIIAYIDGDGVGQDVMPVMRKVVDSAIAHCYQAKRKIHWMQVYNGEQAAKLYDGDW 87 Query: 57 LPPATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQG 116 P T+ + + G + P R + LR+ LF N+R K + Sbjct: 88 FPQETINAVRECKIAIKGPLTTPLGGGF-------RSLNVALRQEMDLFVNMRTIKGFSA 140 Query: 117 LEAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFD------------- 163 L PL+ +I +R+ + +Y G + + GS + EK D Sbjct: 141 LP--SPLKNPYL---TNITVLRDSSEDVYSGI-EWQAGSVESEKVLDFLCEEMGVTRLRF 194 Query: 164 -------TEVYHRFEIERIARIAFESARKRRH-KVTSIDKANVLQ-SSILWREIVNEIAT 214 + + ER+ R A A K +T + K NVL+ + ++ +A Sbjct: 195 TQECGIGIKNISKEGSERLVRYAINYALKNNSESLTLVHKGNVLKFTDGAFKRWGFALAK 254 Query: 215 -EY------------------PDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSD 255 EY P + + + DN Q + P QFDV+ +N GD L+D Sbjct: 255 REYQAIDDENGRWLHIPRQGQPPLIIKEVIADNMLQQCLMHPEQFDVVATTNQNGDFLAD 314 Query: 256 ECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDA 315 + G +G++P+A+LN + +EP G+ IAG+N ANP + ILS L+L++ + Sbjct: 315 MLSAQVGGVGIMPAANLNNE-VAFFEPTHGTFARIAGQNKANPSSSILSAVLMLKF-MQW 372 Query: 316 DDAACAIERAINRALEEGIRTGDLAR---GAAAVSTDEMGDIIARY 358 +AA IE A+ R L G T DL + +S + + + Sbjct: 373 HEAANLIENALERTLAAGEVTFDLLSEPHNSMPLSCTDFALRVIEH 418 >UniRef50_D2Y061 Isocitrate dehydrogenase n=1 Tax=Bombyx mori RepID=D2Y061_BOMMO Length = 388 Score = 276 bits (706), Expect = 9e-73, Method: Composition-based stats. Identities = 102/355 (28%), Positives = 159/355 (44%), Gaps = 31/355 (8%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 + + +LPG GIGPE M + + I D+ +DN + Sbjct: 56 RHAVTMLPGGGIGPECMGYVRDIFKYI----GAPIDFEVVDIDP-TMDNDDDV--QYAIT 108 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 ++ L G++ + LR +++ + K Y G+ Sbjct: 109 TIKRNGVGLKGNIETKSEAAYVT------SRNVALRNELDMYAYILNCKSYPGVAT---- 158 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 D++ +R+ T G Y + +G E +V ER+AR AFE A Sbjct: 159 ----RHKDIDVVIIRQNTEGEYA-MLEHESVNGVVE---SMKVVTADNSERVARFAFEFA 210 Query: 184 RKR-RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFD 241 +K R KVT++ KAN+++ S L+ E +A EYPD+E M IDN MQL+ P QFD Sbjct: 211 KKNGRKKVTTVHKANIMKLSDGLFLETSRRLAKEYPDIEHDDMIIDNCCMQLVAKPHQFD 270 Query: 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQ 301 V+L +NL+G I+S+ + G G+L + + + IAGKNIANPIA Sbjct: 271 VMLMTNLYGSIVSNVVCGLLGGAGLLSGRNYGDHYAVFEPGTRNTGTAIAGKNIANPIAM 330 Query: 302 ILSLALLLRYSLDADDAACAIERAINRALE-EGIRTGDLARGAAAVSTDEMGDII 355 I + +L + L A + RAIN+ + + + T DL G + STD +G I+ Sbjct: 331 INASIDMLEH-LGHQFHASLLRRAINKTINVDRVLTPDL--GGSNTSTDVVGAIL 382 >UniRef50_O15384 NAD (H)-specific isocitrate dehydrogenase gamma subunit (Fragment) n=42 Tax=Coelomata RepID=O15384_HUMAN Length = 296 Score = 272 bits (696), Expect = 1e-71, Method: Composition-based stats. Identities = 76/274 (27%), Positives = 129/274 (47%), Gaps = 20/274 (7%) Query: 61 TVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAF 120 + + L G++ +LPP + LR L++N+ K G+ Sbjct: 19 AIMAIRRNRVALKGNIET--NHNLPPSHKSRNNI---LRTSLDLYANVIHWKSLPGVVT- 72 Query: 121 CPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAF 180 DIL VRE T G Y + +G E ++ + + RIA AF Sbjct: 73 -------RHKDIDILIVRENTEGEYSS-LEHESVAGVVE---SLKIITKAKSLRIAEYAF 121 Query: 181 ESAR-KRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPS 238 + A+ R KVT++ KAN+++ L+ + E+A YP + +M +DN TMQL+ P Sbjct: 122 KLAQESGRKKVTAVHKANIMKLGDGLFLQCCREVAARYPQITFENMIVDNTTMQLVSRPQ 181 Query: 239 QFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANP 298 QFDV++ NL+G+I+++ CA + G G++ A+ + IA KNIANP Sbjct: 182 QFDVMVMPNLYGNIVNNVCAGLVGGPGLVAGANYGHVYAVFETATRNTGKSIANKNIANP 241 Query: 299 IAQILSLALLLRYSLDADDAACAIERAINRALEE 332 A +L+ ++L + L A +I +A+ +++ Sbjct: 242 TATLLASCMMLDH-LKLHSYATSIRKAVLASMDN 274 >UniRef50_UPI000186E03D isocitrate dehydrogenase, putative n=1 Tax=Pediculus humanus corporis RepID=UPI000186E03D Length = 406 Score = 270 bits (692), Expect = 4e-71, Method: Composition-based stats. Identities = 93/361 (25%), Positives = 154/361 (42%), Gaps = 34/361 (9%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 ++ +L G GIGPE+M L+VL A + I G D + Sbjct: 39 NVTILTGSGIGPEIMDHTLRVLKAAGAPLSYEIFALSSKDGSKNNDF------DEALTSI 92 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 + L G++ L + + RK LF + K + GL Sbjct: 93 RRNRVALKGNI------ELQSKNPHIKSRNIIFRKTLDLFVYILFCKTFPGLSN------ 140 Query: 126 DIAANGFDILCVRELTGGIYFG-QPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESAR 184 DI +R+ T G Y + + R GS + +V RF +ER+ AF+ A Sbjct: 141 --KFGEIDITVIRQNTEGEYLMLEHEPRTGSVE-----SLKVLTRFNLERLIEFAFDYAL 193 Query: 185 KR-RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDV 242 R +T + AN+ + + L+ N+I+ YP +++ + ++ A ++ +P FDV Sbjct: 194 TNDRKLITVVHNANIQKLTEGLFLNAANKISKSYPMIKMNVLDVNVAIFKIASNPRIFDV 253 Query: 243 LLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPA-GGSAPDIAGKNIANPIAQ 301 +L +NL G ++S+ + G G+ + + G ++EP I G N ANPIA Sbjct: 254 ILATNLNGSMISNYLNGMLGGPGLTSGINFSADGIAVFEPGARNKGSSIVGLNRANPIAM 313 Query: 302 ILSLALLLRYSLDADDAACAIERAINRALE-EGIRTGDLARGAAAVSTDEMGDIIARYVA 360 I+S LL + L + A I ++ L + IRT D+ A A +E D I R++ Sbjct: 314 IMSGINLL-HHLGYNKTAEMIHNSVYATLVYDKIRTPDIGGQATA---EETVDHIIRHIR 369 Query: 361 E 361 E Sbjct: 370 E 370 >UniRef50_A9KQX3 Isocitrate dehydrogenase (NAD(+)) n=5 Tax=cellular organisms RepID=A9KQX3_CLOPH Length = 387 Score = 269 bits (687), Expect = 1e-70, Method: Composition-based stats. Identities = 95/366 (25%), Positives = 164/366 (44%), Gaps = 36/366 (9%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQ---PLPPATVE 63 I V GDGIGP + +QA ++L+ + ++ + G I+ +P ++ Sbjct: 44 IGVCGGDGIGPAITSQAQRILEYLLKDDILQGKVEFKVIDGLTIERRAAEHAAIPAEVLK 103 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 ++ +L G P+ P+ + A + +RK LF+N+RP + Sbjct: 104 ELKECHVILKGPTTTPRKGDPWPNVE---SANVAMRKELDLFANVRPVR----------- 149 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 I G D RE T G Y KG + + D V ERI R AFE A Sbjct: 150 ---IPEQGIDWTFYRENTEGAYAVGSKGIHVT--EDLGVDFTVVTSGGSERIIRAAFEYA 204 Query: 184 RKRRH-KVTSIDKANVLQS-SILWREIVNEIATEYPDVELAHMYIDNATMQLI--KDPSQ 239 + +VT++ KAN++++ + +I EIA +Y D+ YID T +LI K Sbjct: 205 KANGKTRVTAVTKANIIKTTDGKFLDIFREIAKDYKDITADDWYIDIMTAKLIDEKRRKD 264 Query: 240 FDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNI---A 296 F V++ NL+GDI++DE A G +G SA++ ++ + ++E GSAP + + A Sbjct: 265 FQVMVLPNLYGDIITDEAAEFQGGVGTAGSANIGKR-YSMFEAIHGSAPRMVQEGRDQYA 323 Query: 297 NPIAQILSLALLLRYSLDADDAACAIERAIN--RALEEGIRTGDLARGAAAVSTDEMGDI 354 +P + I + A+LL + + A + +A++ E+ + + + E D Sbjct: 324 DPCSVIRAGAMLLAH-IGYGKEADKLYQALDICTVTEKKLV---ITGRNTGATGAEFADY 379 Query: 355 IARYVA 360 I + Sbjct: 380 IMETIE 385 >UniRef50_UPI000185C11E 3-isopropylmalate dehydrogenase n=1 Tax=Corynebacterium amycolatum SK46 RepID=UPI000185C11E Length = 394 Score = 268 bits (686), Expect = 2e-70, Method: Composition-based stats. Identities = 115/400 (28%), Positives = 166/400 (41%), Gaps = 69/400 (17%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 I +LPGDGIGPE+ ++ V + + + +G + HG P+P T E Sbjct: 16 RITLLPGDGIGPEITDACRGLIADVFPHWEL----TETQIGWSQWRAHGNPVPQETWETL 71 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPE--------RGALLPLRKHFKLFSNLRPAKLYQGL 117 ++DA L ++ + P R +L LR+ LF+N+RP G Sbjct: 72 GRSDAALLAAITSKPAREAEEELAPHLRGTGLNYRSPVLQLRQRLDLFANIRPV-TLPGA 130 Query: 118 EAFCPLRADIAANGFDILCVRELTGGIYF-------------------------GQPKGR 152 A D VRE T G+Y R Sbjct: 131 AA-------------DFTIVRENTEGLYSHDYLLPPHDAPADSPHHHLWAEVVEDSTVAR 177 Query: 153 EGSGQYEKAFDTEVYHRFEIERIARIAFESARKRR---------HKVTSIDKANVLQ-SS 202 + E A V F R+AR A + A R+ VT DK N+L+ S+ Sbjct: 178 AVDKRGEVAVSLRVTTSFAWHRLARQAAKLALARQAANPDSEVTPTVTVADKPNILRDSA 237 Query: 203 ILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITG 262 + R V E+A EYP V D MQL+ DP++FDV++ NL GDILSD A + G Sbjct: 238 RVIRGAVEEVAEEYPQVAFDFANADAVAMQLVTDPARFDVIIAENLIGDILSDIGAGLIG 297 Query: 263 SMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDA---A 319 +G+ SA++ + F ++EP GSAPDIAG+ IANP A +LS A+ + A Sbjct: 298 GLGLAASANVGDN-FAVFEPVHGSAPDIAGRGIANPAAFLLSAAMCAEHLGAPVSELAPA 356 Query: 320 CAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYV 359 + A+ A T DL +T E + + Sbjct: 357 AKLREAVYAATRTAP-TLDL---GGTATTSEFVAAVRAEL 392 >UniRef50_Q2HAA2 Putative uncharacterized protein n=2 Tax=Chaetomium globosum RepID=Q2HAA2_CHAGB Length = 335 Score = 268 bits (685), Expect = 2e-70, Method: Composition-based stats. Identities = 145/365 (39%), Positives = 199/365 (54%), Gaps = 43/365 (11%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFA--MRITTSHYDVGGAAIDNHGQPLPPAT 61 ++I V GD GPEV+ +A+KVL A+ + + +GGA+I H PL Sbjct: 3 THNIVVFGGDHCGPEVVAEAVKVLRAIETHSPSVGKFNLQEHLLGGASIKVHNDPLTAKA 62 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKL-YQGLEAF 120 + + ADA+L G++GGP+W P +PE G LL LRK + NLRP L Sbjct: 63 LAAAKAADAILLGAIGGPEWGPSSP-VRPEEG-LLRLRKELGTYGNLRPCNFASDSLVDS 120 Query: 121 CPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAF 180 PL+AD+ G D + VRELTGGIYFG +GSG A DT+ Y R EIERIAR+A Sbjct: 121 SPLKADVC-RGTDFIVVRELTGGIYFGARTEDDGSG---FAMDTDAYSRAEIERIARLAG 176 Query: 181 ESARKR--RHKVTSIDKANVLQSSILWREIVNEI-ATEYPDVELAHMYIDNATMQLIKDP 237 A KV S+DKANVL +S LWR++V E+ A E+P +E+ H ID+A M ++K P Sbjct: 177 FLALGTSPPSKVWSLDKANVLATSRLWRKVVTEVFANEFPQLEVGHQLIDSAAMLMVKSP 236 Query: 238 SQFD-VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIA 296 + V++ SNLFGDI+SDE ++I GS+G I Sbjct: 237 RALNGVVVTSNLFGDIISDEASVIPGSIG---------------------------AGIV 269 Query: 297 NPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIA 356 NPI ILS+A++LRYSL+ A A+E A+ AL+ G RT DL + T +M D + Sbjct: 270 NPIGTILSVAMMLRYSLNLPKEAAAVEAAVRTALDNGTRTKDL---GGSAGTFQMADAVV 326 Query: 357 RYVAE 361 + + Sbjct: 327 VELVK 331 >UniRef50_C9SEZ4 Homoisocitrate dehydrogenase n=1 Tax=Verticillium albo-atrum VaMs.102 RepID=C9SEZ4_VERA1 Length = 316 Score = 265 bits (678), Expect = 2e-69, Method: Composition-based stats. Identities = 115/360 (31%), Positives = 176/360 (48%), Gaps = 48/360 (13%) Query: 1 MS-KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPP 59 MS + I ++PGDGIG EV+ ++L+A+ + ++ + G + G LP Sbjct: 1 MSIRTLRIGLIPGDGIGKEVIPAGRRILEALPSYLGLKFEFTDLHAGFETFERTGAALPD 60 Query: 60 ATVEGCE-QADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLE 118 TVE + D LFG+V P + ++ LRK L++N+RP K Sbjct: 61 KTVEILRNECDGALFGAVSSPS-----SPVKGYSSPIVALRKKLDLYANVRPVKTVLS-- 113 Query: 119 AFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARI 178 AA D++ VRE T +Y + R+ + A + RIA + Sbjct: 114 ---------AAKPIDMVIVRENTEDLYVKEETTRDTPDG-KVAEAIKRISERASHRIATM 163 Query: 179 AFESARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPS 238 A + A RR K+ + ++ QS P V + H N ++L Sbjct: 164 AGDIAL-RRQKIRAAGAPSIHQS---------------PLVTITHK--SNVLLRL----- 200 Query: 239 QFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANP 298 +V++ NL+GDILSD+ A + GS+G++PSA++ E GF + EP GSAPDI G+NIANP Sbjct: 201 -KNVIVDPNLYGDILSDDAAALVGSLGLVPSANVGE-GFAIGEPCHGSAPDIMGQNIANP 258 Query: 299 IAQILSLALLLRYSLDADDAACAIERAINRALEEGI-RTGDLARGAAAVSTDEMGDIIAR 357 IA + S AL+L + LD + AA I A++ L EG + DL G A +T+ + DI+ R Sbjct: 259 IATLRSAALMLEF-LDEEAAAAKIYAAVDANLTEGKLLSPDL--GGTAKTTEVIEDILRR 315 >UniRef50_UPI000038E0FC 3-isopropylmalate dehydrogenase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI000038E0FC Length = 356 Score = 265 bits (678), Expect = 2e-69, Method: Composition-based stats. Identities = 97/373 (26%), Positives = 168/373 (45%), Gaps = 45/373 (12%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCE 66 IAV+PGDGIG E++ Q ++ ++ + + Y++ N G + + ++ + Sbjct: 4 IAVIPGDGIGKEIIPQVCDLVTSIDP----SVNFTFYNISSERYINKGITIKDSEIDELK 59 Query: 67 QADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRAD 126 +++ FG++G + E+G +L LRK L+ N+RPA + + Sbjct: 60 SYNSIFFGAIG----DFRVKPGIMEQGVILRLRKELDLYMNIRPAISF----------SR 105 Query: 127 IAANGFDILCVRELTGGIYFGQPKG-------------------REGSGQYEKAFDTEVY 167 I N + +RE Y + Sbjct: 106 ITGNNIHMTILRENKEDFYSDISGSLNEHKLFRQKGNFYNYNIDINSESDDTIYYTMGFL 165 Query: 168 HRFEIERIARIAFESARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYID 227 R ++R +A++ A VT DKAN + LWREI E +E ++ Y D Sbjct: 166 SRKNLKRFFNMAYKIADTE--TVTITDKANAVDMYSLWREIAIE-ESEPAGKKINFEYAD 222 Query: 228 NATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSA 287 + +I +P ++ ++ NL+GDILSD + + G +G PS ++ + ++EP GSA Sbjct: 223 SLAYNMINNPLKYRYIIAPNLYGDILSDMSSAMVGGLGYAPSGNIGDYS-SMFEPVHGSA 281 Query: 288 PDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVS 347 PDIAGKNIANP+A ILS ++L++ L+ + A +E+++ + G T + G A Sbjct: 282 PDIAGKNIANPVASILSCIMMLKH-LNQTETAGIMEKSVENVIRNG--TIPIESGGNA-G 337 Query: 348 TDEMGDIIARYVA 360 T E + + Y Sbjct: 338 THEFINKVKNYCT 350 >UniRef50_D2VM48 Isocitrate dehydrogenase n=1 Tax=Naegleria gruberi RepID=D2VM48_NAEGR Length = 432 Score = 264 bits (674), Expect = 5e-69, Method: Composition-based stats. Identities = 99/410 (24%), Positives = 167/410 (40%), Gaps = 79/410 (19%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAI--------------- 50 + +LPGDGIG E+ + ++ + I Y V G+ Sbjct: 39 KVTLLPGDGIGVEICSCVCELFHYAN----IPIQWDTYLVSGSFFGVGSDSSLNPTRNLI 94 Query: 51 ----DNHGQPLP-----------------------PATVEGCEQADAVLFGSVGGPKWEH 83 G+ P P + VL G Sbjct: 95 EEDPRRRGETNPSGGTAYSYLRKEKWSQIDPEVHYPDLHQSILNNKVVLKGP-------F 147 Query: 84 LPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRADIAANGFDILCVRELTGG 143 + D +L L + L++++ P K Q L P D++ VRE T Sbjct: 148 ITRDVSKSIDRMLAL--KYGLYAHVVPVKAPQNL----PPSVFTPFRDVDMVVVRENTEA 201 Query: 144 IYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARK-RRHKVTSIDKANVLQ-S 201 Y G E Q ++ R RIA+ AFE A++ +R KV +I KAN+++ S Sbjct: 202 EYSG----LEHQVQPGVVESLKIITRDGSMRIAKWAFEYAKQSKRSKVIAIHKANIMKKS 257 Query: 202 SILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFD--VLLCSNLFGDILSDECAM 259 L+ E ++A EYPD++ + + +DNA MQL+K+P FD V++ NL+G I+S+ + Sbjct: 258 DGLFIECCKQVAKEYPDIQYSELIVDNAVMQLVKNPHSFDNSVVVTPNLYGSIVSNTASS 317 Query: 260 ITGSMGMLPSASLNEQGFG-----LYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLD 314 + G +G++ + + + A DI+G+ IANPI I S +L + + Sbjct: 318 LVGGVGVISGFNATDINKPDAVRVFEQGNRHVAMDISGRLIANPIGLISSSIQMLDH-MG 376 Query: 315 ADDAACAIERAINRAL---EEGIRTGDLARGAAAVSTDEMGDIIARYVAE 361 + A I+ A+ L I T D+ ++VS + + R++ + Sbjct: 377 MNTHANRIKFALKETLLNANPKILTPDIGGTGSSVS---FIEAMMRHIPK 423 >UniRef50_UPI00016C59BF Isocitrate dehydrogenase (NAD+) n=1 Tax=Gemmata obscuriglobus UQM 2246 RepID=UPI00016C59BF Length = 341 Score = 259 bits (663), Expect = 9e-68, Method: Composition-based stats. Identities = 89/343 (25%), Positives = 152/343 (44%), Gaps = 26/343 (7%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 + + G G+G + ++ A + + + + G A+++ LP AT + Sbjct: 3 KVIFVQGGGLGQDQELSVRRLFAAAK----VPVEFEVHLAGRMALEHGKDALPKATFDAI 58 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGA---LLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 + L + PK +P P + R+ LF+++RP G+ + Sbjct: 59 RECGLALKTKLLQPKGVGMPTAHGPSSVPTNYNVAFRRQLGLFASMRPVHNLPGIPS--- 115 Query: 123 LRADIAANGFDILCVRELTGGIY-FGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFE 181 G D L RE+T +Y + + G Q ++ R ++AF+ Sbjct: 116 -----RFTGVDFLLFREITEDLYTASEHEIVPGVVQ-----SFKIVTEAACLRFFKLAFD 165 Query: 182 SARKR-RHKVTSIDKANVLQS-SILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQ 239 +ARKR R V I KAN+L+ L+ E +A EYP++ + +DN QL+ P Q Sbjct: 166 TARKRGRKTVHCIHKANILKMADGLFLECFYRVAKEYPEIAAKDLIVDNTCNQLVSRPQQ 225 Query: 240 FDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPI 299 F+VL NL+GD+LSD A + G + + + G +YE G++ + +++NP+ Sbjct: 226 FEVLAAGNLYGDLLSDLGAGLVGGVSTTAAINKGN-GTTVYEAVYGASHEAVPPDMSNPL 284 Query: 300 AQILSLALLLRYSLDADDAACAIERAINRALEEG-IRTGDLAR 341 IL LL+ L A I++A+ L EG IRT D+ Sbjct: 285 PLILPAIELLK-DLGETGTAGRIQKAVETVLLEGRIRTRDIGG 326 >UniRef50_A9B3D4 Isocitrate/isopropylmalate dehydrogenase n=4 Tax=Bacteria RepID=A9B3D4_HERA2 Length = 246 Score = 259 bits (662), Expect = 1e-67, Method: Composition-based stats. Identities = 73/263 (27%), Positives = 112/263 (42%), Gaps = 38/263 (14%) Query: 5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEG 64 + + ++ GDG GPE+ +VL+A F I D G ++ G PLP + +E Sbjct: 3 HRVTLIRGDGTGPELAEATRRVLEATGVAFDWDIQ----DAGVDVMEQLGTPLPDSVLES 58 Query: 65 CEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 L + P R + +RK L++ +RP + Y G+ + Sbjct: 59 IRSTKVALKAPITTPVGTGF-------RSVNVAIRKELDLYACVRPCRSYPGVRS----- 106 Query: 125 ADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEK-----------------AFDTEVY 167 D++ VRE T +Y G R E + Sbjct: 107 ---RFENIDLVVVRENTEDLYAGIEFERGTDEVAELRNWLLQKRPNALIKEPGGISIKPM 163 Query: 168 HRFEIERIARIAFESARKR-RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMY 225 ERI R AFE AR R KVT++ KAN+++ S L+ E+ E+A EYPD+E Sbjct: 164 SVPGSERIVRFAFEYARANKRKKVTAVHKANIMKFSDGLFLEVAREVAKEYPDIEFDDRI 223 Query: 226 IDNATMQLIKDPSQFDVLLCSNL 248 +DN MQL++ P +DV++ NL Sbjct: 224 VDNMCMQLVQKPELYDVMVLPNL 246 >UniRef50_D2RML7 Isocitrate/isopropylmalate dehydrogenase n=6 Tax=cellular organisms RepID=D2RML7_ACIFE Length = 393 Score = 258 bits (659), Expect = 3e-67, Method: Composition-based stats. Identities = 87/368 (23%), Positives = 154/368 (41%), Gaps = 38/368 (10%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNH---GQPLPPATV 62 + +LPGDGIGP +M QAL+V + + G I+ + LP + Sbjct: 48 TVGILPGDGIGPCIMEQALRVAKYLLKDEMASGKVEFRTIPGMTIEERVQKNESLPAEVL 107 Query: 63 EGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 E C+ D ++ G P+ P+ LR+ +L++ +RP + Sbjct: 108 EACKACDVLVKGPFVTPRAGDPWPNMVSANSL---LRRALQLYAAVRPVR---------- 154 Query: 123 LRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFES 182 I G D RE G Y KG + + A D +V R ERI R AFE Sbjct: 155 ----IPEKGIDWTFFRENIEGEYIWGNKGIQVDD--DLAVDFKVLTRPGAERICRAAFEF 208 Query: 183 ARKRRHK-VTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKD--PS 238 A+ VT + KAN+++ + + + + EYP + + +D+ ++ Sbjct: 209 AKNNGKTNVTVVTKANIVKLVDGNFLKTAHALEKEYPGITVREELVDSMAAKITDQEFTK 268 Query: 239 QFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNI--- 295 V L NL+GDI++D A G +G S+++ +Q + L+E G + N Sbjct: 269 GMQVFLLPNLYGDIVTDVAAEYQGGLGTASSSNIGDQ-YALFEAIHGVGNFLVQHNRAQY 327 Query: 296 ANPIAQILSLALLLRYSLDADDAACAIERAIN---RALEEGIRTGDLARGAAAVSTDEMG 352 A+P + I ++ ++ + + + + +A++ R + + T D GA A +E Sbjct: 328 ADPCSLIRAMGEMISH-IGYPEKKEQLVKALDICTRTERKVVITTD-KDGATA---EEFT 382 Query: 353 DIIARYVA 360 D + + Sbjct: 383 DYLLDTLQ 390 >UniRef50_B5RJP2 FI08066p (Fragment) n=18 Tax=Sophophora RepID=B5RJP2_DROME Length = 408 Score = 256 bits (654), Expect = 9e-67, Method: Composition-based stats. Identities = 80/360 (22%), Positives = 148/360 (41%), Gaps = 41/360 (11%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPAT 61 K + ++ G+G+G E+M +V+ AV+ +DV + P Sbjct: 84 KKTTKVTLINGEGVGRELMDAVQEVICAVKAPI-------EWDVHDEFKAKDSDDVSPEV 136 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 ++ + G V W+ +RK F F+ + +GL Sbjct: 137 LKSLRANKVGIKGPVDSRHWQR-------------QIRKQFAQFAYVSLCSHIEGL---- 179 Query: 122 PLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFE 181 D FD++ +R+ G Y G E +V RIA F Sbjct: 180 ----DSPYGDFDVVIIRDQMEGDYSG----IEHLVVPGVMQTIKVSTTAGAARIAEFVFN 231 Query: 182 SARKR-RHKVTSIDKANVLQ-SSILWREIVNEIATEY-PDVELAHMYIDNATMQLIKDPS 238 A K R ++T KAN+++ + + E + A ++ DV Y+D ++++ P Sbjct: 232 YAVKNKRKRITVAHKANIMRMTDGNFLEAMRAEADKHVDDVLFEERYLDTCILKILLKPH 291 Query: 239 QFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANP 298 + DV++ S+++GD+L + G G+ P S++ G +++ + +AGK++ANP Sbjct: 292 KCDVMVSSSMYGDVLRVIAGGMMGVPGICPGYSVSSLGT-VFDCRMKACHALAGKDLANP 350 Query: 299 IAQILSLALLLRYSLDADDAACAIERAINRALEE-GIRTGDLARGAAAVSTDEMGDIIAR 357 +LS AL+LR+ + D A ++ AI + ++ IRT D+ E + Sbjct: 351 TGPLLSAALMLRH-VKMDKQADQVDCAIRKVYKDTDIRTPDV---GGKAKCSEFVKAVCD 406 >UniRef50_B8FQF2 Isocitrate/isopropylmalate dehydrogenase n=2 Tax=Desulfitobacterium hafniense RepID=B8FQF2_DESHD Length = 374 Score = 253 bits (646), Expect = 1e-65, Method: Composition-based stats. Identities = 115/367 (31%), Positives = 163/367 (44%), Gaps = 28/367 (7%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFA-MRITTSHYDVGGAAIDNHGQPLPPAT 61 K Y IAV+P DG+G +V+ K + + + +Y+ G G+ Sbjct: 2 KKYTIAVIPLDGVGKDVIPLGAKAMQKAQEILGGFELDCRYYEAGVEYAVKTGKMCEDNL 61 Query: 62 VEGCEQADAVLFGSVGGPKWEHLP---PDQQPERGALLPLRKHFKLFSNLRPAKLYQGLE 118 E +ADA+L GS G + P + L LR LRP +L +G++ Sbjct: 62 GEDIAKADAMLCGSAGHYDADMSKSEYPGYKTGMQVLQFLRSGMGNSIGLRPLRLRKGID 121 Query: 119 AFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARI 178 CPLR D+L VR+L G Y +P G + A+DT V R E+ A Sbjct: 122 --CPLRN---REEIDVLLVRQLAEGFYI-RPGHMIG---EDAAYDTIVVTRNVTEKFADT 172 Query: 179 AFESARKR-------RHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATM 231 F AR R + VT +K + +R+I E++ YPD+ L +D Sbjct: 173 CFRLARGRHGRRQDGKKMVTLGNKHGNVTCFDFYRKIFTEVSAGYPDIGLQFTQVDALAE 232 Query: 232 QLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIA 291 LIKDP +FDV+ C N+ GDI+ D A ITG MG+ P+A + + P G+ P Sbjct: 233 HLIKDPDRFDVIACENMIGDIIGDIGAYITGGMGITPTADVGGVTP-QFRPNHGTFPRAV 291 Query: 292 GKNIANPIAQILSLALLLRYSLDA------DDAACAIERAINRALEE-GIRTGDLARGAA 344 GK ANP+A IL+ LLL + A IE+A+ L G RT DL A Sbjct: 292 GKGFANPLASILTAGLLLDTLGNERGDDNLRRGARLIEKAVEYNLTTGGPRTKDLGGTAN 351 Query: 345 AVSTDEM 351 +T E Sbjct: 352 TFATAEA 358 >UniRef50_Q6L0K7 3-isopropylmalate dehydrogenase n=1 Tax=Picrophilus torridus RepID=Q6L0K7_PICTO Length = 335 Score = 248 bits (634), Expect = 2e-64, Method: Composition-based stats. Identities = 91/343 (26%), Positives = 151/343 (44%), Gaps = 44/343 (12%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCE 66 +A++PGDGIG E+M A I +D+ G + +E + Sbjct: 4 VALIPGDGIGREIMPGV-----AAAISSISDINFVTFDISSERYIKTGIIIKDDELEELK 58 Query: 67 QADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRAD 126 A+LFG++G P+ E+G +L LR+ +L+ N+RP + + Sbjct: 59 NYRAILFGAIGDPRVR----PGIMEQGVILRLRRELELYMNIRPVRSFD----------- 103 Query: 127 IAANGFDILCVRELTGGIYFGQPK---------------GREGSGQYEKAFDTEVYHRFE 171 + I +RE T Y +GS E + + Sbjct: 104 ---DKIKITILRENTQDFYTDISGIIPGKRSFNVNGTRIEIDGSSCDEVYYTMGMLSYRY 160 Query: 172 IERIARIAFESARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATM 231 +++ AF VT DKAN ++ LWR E A E ++ ++ Y D Sbjct: 161 LKKFFNKAFSIC---DSTVTVTDKANAVKMYNLWRSTAMEAAIE-KNINISFEYADALAY 216 Query: 232 QLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIA 291 +I +P ++ ++ NL+GDI+SD A + G +G PSA++ ++ L+EP GSAPDIA Sbjct: 217 NMILNPKKYRYIIAPNLYGDIISDMGAALVGGLGYAPSANIGDKN-ALFEPVHGSAPDIA 275 Query: 292 GKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGI 334 G+++ANP A I++ ++LL Y L D + I + G+ Sbjct: 276 GRDMANPAASIMAGSMLLEY-LGYRDESRIINDMVRNLYINGV 317 >UniRef50_C0W9Q2 Isocitrate dehydrogenase n=2 Tax=Clostridiales RepID=C0W9Q2_9FIRM Length = 387 Score = 246 bits (628), Expect = 1e-63, Method: Composition-based stats. Identities = 84/370 (22%), Positives = 159/370 (42%), Gaps = 40/370 (10%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNH---GQPLPPATV 62 + ++PGDGIGP +M AL V + + + G I+ + LPPA + Sbjct: 39 KVGIMPGDGIGPYIMKAALLVARKLLKKEIADQRVEFVPIKGMTIEERARQNKSLPPAVL 98 Query: 63 EGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 E C+ D ++ G P+ P+ LR+ +L++ +RP + Sbjct: 99 EACKACDILVKGPFVTPRAGDRWPNLLSANSL---LRRQLQLYAAVRPIR---------- 145 Query: 123 LRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFES 182 I G D RE G Y KG + A D ++ + ER+ R AFE Sbjct: 146 ----IPEKGIDWTFFRENIEGEYIWGNKGICVGD--DLAIDFKILSKPGAERLFRNAFEY 199 Query: 183 ARKRRHK-VTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPS-- 238 A+ +T KAN+++ + ++ + + EYP + + ID+ + +L+ DP Sbjct: 200 AKSSGKTNITVATKANIVKLVDGNFLKVAHAMEKEYPGIHVREELIDSLSAKLM-DPEFN 258 Query: 239 -QFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNI-- 295 V + NL+GDIL+D A G +G S+++ +Q + ++E G + N Sbjct: 259 AGMQVFVLPNLYGDILTDIAAEYQGGLGTASSSNIGDQ-YAMFEAIHGVGVYLVEHNRAQ 317 Query: 296 -ANPIAQILSLALLLRYSLDADDAACAIERAIN---RALEEGIRTGDLARGAAAVSTDEM 351 A+P + I ++ ++ + + + + +A++ + + + T D GA A +E Sbjct: 318 YADPSSLIRAMGEMMAF-IGYPEKRDRLFKALDFCTKVERKAVITTD-KDGATA---EEF 372 Query: 352 GDIIARYVAE 361 + + + + Sbjct: 373 AEYVVETLHK 382 >UniRef50_C7YX79 Putative uncharacterized protein (Fragment) n=1 Tax=Nectria haematococca mpVI 77-13-4 RepID=C7YX79_NECH7 Length = 352 Score = 237 bits (604), Expect = 6e-61, Method: Composition-based stats. Identities = 116/358 (32%), Positives = 173/358 (48%), Gaps = 32/358 (8%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRN-RFAMRITTSHYDVGGAAIDNHGQPL-PPA 60 + + +A+LPGDG GP + + + LD ++ R + S +D GG A+ P Sbjct: 8 RPFQVALLPGDGQGPYLASYVERTLDLIQRVRRNVSFKVSRHDFGGVALAAGAGTALPST 67 Query: 61 TVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAF 120 T+ C Q+DAVL G P++ +PERG LL LR+ + N+RP + Sbjct: 68 TLGACRQSDAVLVCGCGDPRY-----GIEPERG-LLTLRQELEGCVNIRPVRFPSSQLVQ 121 Query: 121 CPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAF 180 DI R+LT G+Y+G+ R+ +G +A+DT Y R IERIAR+A Sbjct: 122 QSSYKPEVVEQLDITFFRDLTSGVYYGR---RKEAGDDGEAYDTTPYSRQTIERIARLAG 178 Query: 181 ESARK--RRHKVTSIDKANVLQSSILWREIVNEI-ATEYPDVELAHMYIDNATMQLIKDP 237 A + V SIDK NV+ +S LWR +V + E+P V L H+ +D A+M L DP Sbjct: 179 TYAMQFSPPKPVHSIDKHNVMATSRLWRSVVAHVFENEFPQVPLRHVLVDTASMILSSDP 238 Query: 238 SQFD-VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDI------ 290 + ++L N+FGDILSD+ I GS +L SA+++ + P I Sbjct: 239 LSLNGIILTENMFGDILSDQAGGILGSPDVLASAAVS----AIRRGGSRGTPGIFEPFNL 294 Query: 291 -AGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALE------EGIRTGDLAR 341 G P+ I ++ L+L SL + A+ +AI R L+ RT DL Sbjct: 295 NPGGKTVGPLGSIQAVGLMLELSLGLAAESEALSKAIRRTLDPIELVGSDTRTVDLGG 352 >UniRef50_A6GJ83 Isocitrate dehydrogenase n=1 Tax=Plesiocystis pacifica SIR-1 RepID=A6GJ83_9DELT Length = 344 Score = 234 bits (597), Expect = 4e-60, Method: Composition-based stats. Identities = 90/364 (24%), Positives = 148/364 (40%), Gaps = 37/364 (10%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPA 60 M++ Y I L GDGI E+ V DA+ I D+ + + G + Sbjct: 6 MNR-YSIVELHGDGIARELSQAVHTVADAL----PFEIEFIPVDLSDESREAKGDAIYDE 60 Query: 61 TVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAF 120 + L P + LR+ RP G++ Sbjct: 61 AEAAMRRYGTSLK-----------YPTATTKESPNRVLRERCNFAVIHRPVATIPGIQTH 109 Query: 121 CPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAF 180 R + VR TGG Y + + A R +R AF Sbjct: 110 YNERIHLD-------IVRIATGGTYEDAGR----RINRDTAVSIRAIERRPSVLASRFAF 158 Query: 181 ESARKRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQ 239 A+ R V + K + + + L++E +A +YP E D +I P + Sbjct: 159 RLAQLRDSNVIATSKYTIQKATDGLFQEAARGVARDYPATEFREELFDALLAGIIMRPER 218 Query: 240 FDVLLCSNLFGDILSDECAMITGSMGMLPSASL-----NEQGFGLYEPAGGSAPDIAGKN 294 + V++C N +GD LSD + GS+G+ SAS + +++PAGG+APDIAG+N Sbjct: 219 YGVIVCPNEYGDFLSDMAYGLIGSIGLGDSASYSFDSQGQVDVAMFDPAGGTAPDIAGQN 278 Query: 295 IANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDI 354 ANP A +L++A +LR+ + D++ A+ A+ A+E G +T D+ +++ E + Sbjct: 279 KANPTAALLAMANMLRH-IGEHDSSKALRGALFGAIEAGEKTADI---GGSLNLSEFTQV 334 Query: 355 IARY 358 I Sbjct: 335 IVDR 338 >UniRef50_A4FEJ6 3-isopropylmalate dehydrogenase n=1 Tax=Saccharopolyspora erythraea NRRL 2338 RepID=A4FEJ6_SACEN Length = 407 Score = 234 bits (597), Expect = 5e-60, Method: Composition-based stats. Identities = 93/257 (36%), Positives = 129/257 (50%), Gaps = 20/257 (7%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCE 66 IAV+PGDGIGPE++ A++VL A R + + + D G A G + AT+E Sbjct: 9 IAVIPGDGIGPELVRSAVEVLRAAAGR-DVELRFTSEDAGADAFRRTGSAMSAATLERIR 67 Query: 67 -QADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 + VL G VG P H PD LR ++N+RP L G++ A Sbjct: 68 TRYHGVLKGPVGLPGVRH--PDGTEAGLLGGVLRGGLDTYANVRPIALLPGVD------A 119 Query: 126 DIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARK 185 + D + VRE T G+Y + + G G D + R +ER+ AFE A + Sbjct: 120 PLRGTAVDYVIVRENTEGLYLSRGR---GVGNDRACADQLLMTRHGVERVVVHAFELATR 176 Query: 186 RR-------HKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPS 238 R +VT +DK+NVL+S +RE+ +E+AT YP VE H Y D A L+ DP Sbjct: 177 RTGAPADGVRRVTCVDKSNVLRSFAFFREVFDEVATRYPQVEADHRYADAAGHDLVADPG 236 Query: 239 QFDVLLCSNLFGDILSD 255 +FDVL+ N GDILSD Sbjct: 237 RFDVLVMENFLGDILSD 253 >UniRef50_D2SD16 Malate/L-lactate dehydrogenase n=1 Tax=Geodermatophilus obscurus DSM 43160 RepID=D2SD16_9ACTO Length = 732 Score = 232 bits (592), Expect = 2e-59, Method: Composition-based stats. Identities = 114/365 (31%), Positives = 168/365 (46%), Gaps = 27/365 (7%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 +A+LPGDG+G EV+ ++L + R + + T + VG A G LP T+ C Sbjct: 3 RVALLPGDGVGEEVLDGPTRLLRLLAERGEVEV-TGPWPVGARAAAETGDVLPAGTLAAC 61 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 + ADA+L G+VG +PE AL LR+ + L ++R G E Sbjct: 62 DAADAILLGAVGEDPRVPAGVCPRPEV-ALHRLRERYDLRISVREIPFADGRE------- 113 Query: 126 DIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFE-SAR 184 + VR L GG Y G E A D R + + A + R Sbjct: 114 --------LTVVRNLIGGSYGGADDRVLREDGSEAA-DVLRLTRERVAEVVHTACDVLGR 164 Query: 185 KRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLL 244 + ++ S+DKAN+ + LWR++ ++A E +E+ H Y+D A +L DVL+ Sbjct: 165 RGGGRLVSVDKANLYATGRLWRQVAGDVARER-GIEVEHRYVDRAAFELGSGAPVPDVLV 223 Query: 245 CSNLFGDILSDECAMITGSMGMLPSASLNE------QGFGLYEPAGGSAPDIAGKNIANP 298 L GDILSD A GS + SASL+ + GL+EPA GSAP A ++ +P Sbjct: 224 TEGLLGDILSDLAAGRAGSPALCGSASLHPGEPVRGRCVGLFEPAHGSAPRRALRDQVDP 283 Query: 299 IAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLA-RGAAAVSTDEMGDIIAR 357 + L+LA LLR+ +A + A+ L G T DL G AA ST ++ D + Sbjct: 284 LGGFLALAALLRHFPATREAGERVRAAVGAVLRSGPWTYDLVPEGGAAASTGQVADAVLA 343 Query: 358 YVAEG 362 G Sbjct: 344 AFGSG 348 >UniRef50_Q961P4 GH13226p n=4 Tax=Drosophila RepID=Q961P4_DROME Length = 307 Score = 230 bits (587), Expect = 6e-59, Method: Composition-based stats. Identities = 75/342 (21%), Positives = 137/342 (40%), Gaps = 41/342 (11%) Query: 20 MTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCEQADAVLFGSVGGP 79 M +V+ AV+ +DV + P ++ + G V Sbjct: 1 MDAVQEVICAVKAPI-------EWDVHDEFKAKDSDDVSPEVLKSLRANKVGIKGPVDSR 53 Query: 80 KWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRADIAANGFDILCVRE 139 W+ +RK F F+ + +GL D FD++ +R+ Sbjct: 54 HWQR-------------QIRKQFAQFAYVSLCSHIEGL--------DSPYGDFDVVIIRD 92 Query: 140 LTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARKR-RHKVTSIDKANV 198 G Y G E +V RIA F A K R ++T KAN+ Sbjct: 93 QMEGDYSG----IEHLVVPGVMQTIKVSTTAGAARIAEFVFNYAVKNKRKRITVAHKANI 148 Query: 199 LQ-SSILWREIVNEIATEY-PDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDE 256 ++ + + E + A ++ DV Y+D ++++ P + DV++ S+++GD+L Sbjct: 149 MRMTDGNFLEAMRAEADKHVDDVLFEERYLDTCILKILLKPHKCDVMVSSSMYGDVLRVI 208 Query: 257 CAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDAD 316 + G G+ P S++ G +++ + +AGK++ANP +LS AL+LR+ + D Sbjct: 209 AGGMMGVPGICPGYSVSSLGT-VFDCRMKACHALAGKDLANPTGPLLSAALMLRH-VKMD 266 Query: 317 DAACAIERAINRALEE-GIRTGDLARGAAAVSTDEMGDIIAR 357 A ++ AI + ++ IRT D+ E + Sbjct: 267 KQADQVDCAIRKVYKDTDIRTPDV---GGKAKCSEFVKAVCD 305 >UniRef50_C5GTE7 Tartrate dehydrogenase n=2 Tax=Ajellomyces dermatitidis RepID=C5GTE7_AJEDR Length = 307 Score = 229 bits (585), Expect = 1e-58, Method: Composition-based stats. Identities = 90/334 (26%), Positives = 150/334 (44%), Gaps = 49/334 (14%) Query: 5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRI--TTSHYDVGGAAIDNHGQPLPPATV 62 Y IA + GDGIGPEV+ NR A + S G I + + P Sbjct: 16 YKIAAIRGDGIGPEVIEAGNYQSAEETNRVAWILLNWPSRTLSGAVRITRNTADISP--- 72 Query: 63 EGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 + + F + LPLR SN+ P +++ G+++ Sbjct: 73 --ISSSTFLWF-------------------SSYLPLRSS---TSNM-PTRVFHGIQSPL- 106 Query: 123 LRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFES 182 D + VRE + G Y G +E A D ++ R +ERI + AFE+ Sbjct: 107 --------HLDWVIVRENSEGEYAGHGGRSYAGKPWEVATDISIFTRHGVERIMKFAFEA 158 Query: 183 ARKR-RHKVTSIDKANVLQSS-ILWREIVN-EIATEYPDVELAHMYIDNATMQLIKDPSQ 239 AR R + +T K+N ++ ++W EI E+A ++PDV M +D T +++ P Sbjct: 159 ARSRAKKHITVATKSNAQRNGLVVWDEIAAAEVAAQFPDVTCDKMLVDAMTARVVLTPES 218 Query: 240 FDVLLCSNLFGDILSDECAMITGSMGMLPSASLNE--QGFGLYEPAGGSAPDIAGKNIAN 297 D ++ +NL ILSD + + GS+G+ P+++L+ + ++EP GSA DIAGK++A Sbjct: 219 LDTIVPTNLHAGILSDLASALAGSIGIAPTSNLDPTRENPSMFEPVHGSAFDIAGKDLA- 277 Query: 298 PIAQILSLALLLRYSLDADDAACAIERAINRALE 331 ++A +L + AA +E + + Sbjct: 278 ---TFWTVAEMLSWLGQKGAAAELLE-CVESVCK 307 >UniRef50_B4MP27 GK19462 n=1 Tax=Drosophila willistoni RepID=B4MP27_DROWI Length = 390 Score = 226 bits (576), Expect = 1e-57, Method: Composition-based stats. Identities = 79/327 (24%), Positives = 138/327 (42%), Gaps = 38/327 (11%) Query: 19 VMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCEQADAVLFGSVGG 78 ++ +KV V+ + + + A G+ + P +E + + G Sbjct: 1 MIESLVKVFSTVQVPIDWDV-FHEHKINSA----EGEDVSPKLLESLCRNKIGIKGPFES 55 Query: 79 PKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRADIAANGFDILCVR 138 L LRK F+LF+ + + +G + D L +R Sbjct: 56 -------------GPCLRKLRKKFQLFAFVAVCRNLEG--------QNTRYGKLDCLIIR 94 Query: 139 ELTGGIYFG-QPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARKR-RHKVTSIDKA 196 + G Y G + + G Q +V +R+AR FE A+K R K+T KA Sbjct: 95 DQVEGEYSGIEHRVVPGVMQ-----TIKVSTAEGADRMARYVFEYAKKNNRKKITVAHKA 149 Query: 197 NVLQ-SSILWRE-IVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILS 254 N+++ + + + E A D+ Y+D + ++ P + DVL+ S+++GD+L+ Sbjct: 150 NIMRLTDGTFLSPMRREAAKYQDDIMFEERYLDTVCLAMLMKPERKDVLVASSMYGDVLT 209 Query: 255 DECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLD 314 A I G + P ++ G +YEP + +IAGK+I NP +LS L+LR + Sbjct: 210 FMAASIMGGPALCPGFAVGPMGL-IYEPIIHTNTNIAGKDIVNPTGMLLSGVLMLR-EMK 267 Query: 315 ADDAACAIERAINRALEE-GIRTGDLA 340 ++ A I A++ E RT DL Sbjct: 268 LNEYADKICCAVSTVFRETDCRTKDLG 294 >UniRef50_B0BZF3 Isocitrate dehydrogenase NAD-dependent n=1 Tax=Acaryochloris marina MBIC11017 RepID=B0BZF3_ACAM1 Length = 348 Score = 225 bits (573), Expect = 2e-57, Method: Composition-based stats. Identities = 90/359 (25%), Positives = 150/359 (41%), Gaps = 52/359 (14%) Query: 5 YHIAVL-PGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 Y + ++ G E+ Q L + IT D+GG D G LP + Sbjct: 3 YPVVLIQEG-----ELGAQVTNALQMAIAATGVDITWQIVDIGGE--DQQG-LLPNYIFD 54 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 A + G + P R +R+ L+ NLRPAK G+ + Sbjct: 55 IIRTAKTAVIGPLMMPDN---------YRQMEADIREKLDLYVNLRPAKTMVGIPS---- 101 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEK----------------AFDTEVY 167 DI+ VRE T GIY G R + A + Sbjct: 102 ----NYQNVDIMIVRETTEGIYAGIEFERTSVEAADARSFLSKLSGKRIREDAAVGIKPI 157 Query: 168 HRFEIERIARIAFESARK-RRHKVTSIDKANVL-QSSILWREIVNEIATEYPDVELAHMY 225 +I AF ARK +RH+V ++ +A+ + + L+ EI +IA E+PD+ A Sbjct: 158 SVKGCGQIIEFAFNYARKTKRHQVIAVHQAHFMAHTDGLFLEIARDIAQEFPDIAFADRS 217 Query: 226 IDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGG 285 I+ +L++ P +FDVL+ NL+GD+L+ CA + G + + P A + ++ + ++ Sbjct: 218 IEVICQELMQKPERFDVLVMPNLYGDLLAHLCAGMVGGLSV-PIAHVGDK-YAVFGAQST 275 Query: 286 SAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGI-RTGDLARGA 343 D+ +P + IL+ AL+LR+ L +AA ++ A+ + + T DL Sbjct: 276 GTDDVG----HDPTSLILAGALMLRH-LGEQEAAQRLQAAVEAVVASHVDTTADLNPVG 329 >UniRef50_UPI00017936A6 PREDICTED: similar to isocitrate dehydrogenase, NAD-dependent n=1 Tax=Acyrthosiphon pisum RepID=UPI00017936A6 Length = 423 Score = 223 bits (570), Expect = 6e-57, Method: Composition-based stats. Identities = 77/377 (20%), Positives = 148/377 (39%), Gaps = 42/377 (11%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATV 62 + + V+ G G GP V+ K+ A T + + P + Sbjct: 39 RPIRVTVIEGQGTGPVVLAAVRKIFKAALVPVEWDYQTLSVYRDHKT---NRMTVNPQLL 95 Query: 63 EGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 + + VL P+ L L K F +R G E + P Sbjct: 96 DSAIETGLVLCAKDSSPRQ------NDSLESDSLALHKALNAFVGVRKFNSVVGHEPYGP 149 Query: 123 LRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFES 182 +++ +RE G Y E + + +A++AF+ Sbjct: 150 ---------INLVNIREHVSGEYS----EIEHLVSPGVVQSIKTVSKKISVEVAKLAFDY 196 Query: 183 ARKRRH-KVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQF 240 A K H ++T + KA+V++ S ++ + E++ YPDVE +D+ + + +P ++ Sbjct: 197 ACKHGHSRITVLHKADVMRLSDGIFLKACREVSACYPDVEYNEEKLDSFCLNVTTNPGRY 256 Query: 241 DVLLCSNLFGDILSDECAMITGSMGMLPS----------ASLNEQGFGLYEPAGGSA--- 287 +VLL ++L+G C M++G + +P+ +++ + G+ Y + G Sbjct: 257 EVLLTTSLYGAFAGSVCGMMSGGLVTVPTIAYGPKATVFSTMGDYGYSTYSHSDGDGIFK 316 Query: 288 PDIAGK-NIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAV 346 + G+ I NP I + AL+L ++ C I A+ + +GIRT D+ A Sbjct: 317 KMVYGQEQIINPTGIIRAAALMLDHAGMVVAGRC-IAAAVEDTIRQGIRTQDMGGDA--- 372 Query: 347 STDEMGDIIARYVAEGV 363 S + D I + + + + Sbjct: 373 SCSQFTDAIIKNLKDSM 389 >UniRef50_B1VH60 Putative dehydrogenase n=1 Tax=Corynebacterium urealyticum DSM 7109 RepID=B1VH60_CORU7 Length = 378 Score = 220 bits (560), Expect = 8e-56, Method: Composition-based stats. Identities = 100/350 (28%), Positives = 163/350 (46%), Gaps = 22/350 (6%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLD-AVRNRFAMRITTSHYDVGGAAIDNHGQPLPPA 60 ++ + V G+GIGPE++ ++ ++ A++ +G AI+ G+ +P Sbjct: 4 TETCRLGVWQGEGIGPEIVAPTVQAVELALQASGEATPEFVPLLLGREAINATGRIVPEE 63 Query: 61 TVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAF 120 T E D + G + PP + LRK L++N+RP + G Sbjct: 64 TWETITGLDGWILGPHDNVSY---PPSVAGQLNPSAHLRKQADLWANIRPVRGVPGAVHP 120 Query: 121 CPLRADIAANGFDILCVRELTGGIYFGQP---KGREGSGQYEKAFDTEVYHRFEIERIAR 177 D++ VRE T G+Y + + + E + V+ + +I RI R Sbjct: 121 ----------DLDVVIVRENTEGMYADRNMLMGSGDITVNGEVSLAIGVFTQTKIRRIVR 170 Query: 178 IAFESARKRRHKVTSIDKANVL-QSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKD 236 A A R +T K+NVL ++S + A E+ VE+ ++ID +L+ Sbjct: 171 RAAAIAAARDGVLTVAHKSNVLTETSGRYVAEAKACAEEF-GVEVQPVHIDALCAELVTR 229 Query: 237 PSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIA 296 P ++ ++ N+FGDILSD + GS+G+ S + +E + + A GSAPDIAG+ IA Sbjct: 230 PERYATIVAENMFGDILSDLAGGLGGSLGIAGSINASESQV-MAQAAHGSAPDIAGQGIA 288 Query: 297 NPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAV 346 NP + S A +L SL AA +E A+ A+ + T DL R AAA Sbjct: 289 NPAGIMNSAAQMLD-SLGYPQAAELLEGAVREAVVKAP-TADLVREAAAA 336 >UniRef50_UPI0001C31665 isocitrate/isopropylmalate dehydrogenase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C31665 Length = 368 Score = 210 bits (534), Expect = 9e-53, Method: Composition-based stats. Identities = 85/377 (22%), Positives = 143/377 (37%), Gaps = 33/377 (8%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPA 60 M + I +L GD G E++ QA++VLD + + +D+ + Sbjct: 1 MPEPLKITILEGDETGQELLDQAVRVLD--PEVTGLPLELERFDLSLENRRATQNGVVSD 58 Query: 61 TVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAF 120 + + P+ LR+ +R + G+ Sbjct: 59 AAAAMRTCGFGIKAATITPEGADDV------GSPNRILREEVDGKVIVRTGRRIPGV--- 109 Query: 121 CPLRADIAANGFDILCVRELTGGIYFGQPKGREGSG--QYEKAFDTEVYHRFEIERIARI 178 IA + I VR Y G + REG E A+ TE R ++ Sbjct: 110 ----TPIAGVHYPISIVRMAIEDAY-GAKQWREGDAGAADEVAYRTEHVTRSTCRAVSEY 164 Query: 179 AFESARKRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDP 237 AF +AR + +V K V + +E ++ A +PDV + ID L+ Sbjct: 165 AFRTARAMQARVYGGPKWTVSPVYEGMLKEEMDAAAARHPDVAYEPVLIDATYAGLVSGA 224 Query: 238 SQFDVLL-CSNLFGDILSDECAMITGSMGMLPSASLN-----EQGFGLYEPAGGSAPDIA 291 + +++ N GD LSD + GS+ S L E + E G+AP + Sbjct: 225 ADEPLVVPALNRDGDCLSDLVLPMFGSIAGAESVLLAFDDNYETHVAMAEAPHGTAPALR 284 Query: 292 GKNIANPIAQILSLALLLRY-----SLDADDAACAIERAINRALEEGIRTGDLARGAAAV 346 GK++ANP+A +L+ +LR+ A+ A+ AI ++ A+ GI+T DL Sbjct: 285 GKDVANPMAMLLASGAVLRHAAERGHPGAERASRAIYESVLEAIATGIKTPDL---GGHA 341 Query: 347 STDEMGDIIARYVAEGV 363 T E D + + + Sbjct: 342 GTTEFTDAVIERITTKI 358 >UniRef50_B7KHW3 Isocitrate/isopropylmalate dehydrogenase n=11 Tax=Bacteria RepID=B7KHW3_CYAP7 Length = 363 Score = 206 bits (524), Expect = 1e-51, Method: Composition-based stats. Identities = 87/373 (23%), Positives = 143/373 (38%), Gaps = 28/373 (7%) Query: 1 MSKN-YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPP 59 M++ I V+ GD G E++ QAL+VL + + YD+ + Sbjct: 1 MTQTTPTIVVMHGDQTGEELLIQALRVLQ--PSVIRQPLQFLDYDLSLENRRATDNKVVW 58 Query: 60 ATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEA 119 + + L + P+ LR+ LR + + Sbjct: 59 EAAQAARDSGLSLKAATITPEIAGDV------GSPNAILREALNAKVILRTGRRIPKIRP 112 Query: 120 FCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIA 179 + + IA VR Y + E A+ T R +A Sbjct: 113 IAGVYSPIA-------IVRMAVDDAYGSKEWRETTENGDEIAYRTSKISRSTCRAVAEFT 165 Query: 180 FESARKRRHKVTSIDKANVLQS-SILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPS 238 F+ A++ + KV K V + +++E ++ A YP+V + ID L++ Sbjct: 166 FQYAKRTKAKVFGGPKFTVSATYEGMFKEELDAAAKRYPEVPYQPLLIDATFALLLQTTG 225 Query: 239 QFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFG------LYEPAGGSAPDIAG 292 + V+ N GD+LSD + GS+ S L + + E G+AP + G Sbjct: 226 ESLVIPALNRDGDLLSDMVLQMYGSIAGSESLVLGFESGSDQVKTVMAEAPHGTAPALFG 285 Query: 293 KNIANPIAQILSLALLLRYSL--DADDAACAIERAINRALEEGIRTGDLARGAAAVSTDE 350 KNIANP+A IL+ A LL Y A+ A+ AI ++ + EG T DL ++T E Sbjct: 286 KNIANPMAMILAGAALLSYGRIPQAEKASRAIYESVFETIYEGKATPDL---GGQMTTSE 342 Query: 351 MGDIIARYVAEGV 363 D + R V + Sbjct: 343 FTDEVIRRVETKL 355 >UniRef50_UPI00003C8595 isocitrate dehydrogenase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI00003C8595 Length = 377 Score = 197 bits (502), Expect = 5e-49, Method: Composition-based stats. Identities = 75/378 (19%), Positives = 150/378 (39%), Gaps = 44/378 (11%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRN---RFAMRITTSHYDVGGAAIDNHGQPLP 58 I + GDGIGPE+ + V+++ + + I +G A + G +P Sbjct: 21 PDILTIGYIDGDGIGPEITGAMIGVVNSAIELAYQGSRSIEWHKILIGTEAYEKFGTYVP 80 Query: 59 PATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLE 118 +++ ++ + ++ + PD+ R LRK L+SN+R K +G++ Sbjct: 81 EDSIKEIQKMYIAMKSTL------NFMPDK---RDLNTILRKRLGLYSNIRILKYIEGMD 131 Query: 119 AFCPLRADIAANGFDILCVRELT--GGIYFGQPKGREG-----------SGQYEKAFDTE 165 N ++ +R+ T I++ + + + + Sbjct: 132 IPVN-----TFNRLNLTIIRDSTPNSHIFYHSSESTDDLIRFISDNYGLNITPDSGIYMM 186 Query: 166 VYHRFEIERIARIAFESARKRRHKVTSIDKANVLQSSIL--WREIVNEIATEYPDVELAH 223 +F +IA+ A +R+ K K +L+S + E A+ DV Sbjct: 187 PQSKFRTRKIAKQAVRYSRRNGKK-----KITILESQQNHEFANWCIEEASAQEDVGYEV 241 Query: 224 MYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPA 283 + +LI P F+V+L N+ L D + G++ + +S+ ++ ++E Sbjct: 242 LKTREFMKRLISSPEDFEVILVDNVLSQTLVDY---LAGTINIEYGSSIGDEC-AVFEAV 297 Query: 284 GGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDL--AR 341 S P AG + A+P++ ILS +L + + +AA IE AI+ A + D+ Sbjct: 298 QSSLPSEAGYDAADPLSFILSGCEMLMH-IGWVEAAQIIENAISAAFRDNKIPKDINTRP 356 Query: 342 GAAAVSTDEMGDIIARYV 359 + + E I + + Sbjct: 357 DISPIKCSEFSSEIIKRM 374 >UniRef50_B4PZH5 GE17383 n=3 Tax=Drosophila RepID=B4PZH5_DROYA Length = 268 Score = 186 bits (472), Expect = 1e-45, Method: Composition-based stats. Identities = 58/160 (36%), Positives = 96/160 (60%), Gaps = 6/160 (3%) Query: 201 SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMI 260 S L+ V ++A ++P+++ Y+D + ++++P ++DVL+ NL+GDILSD CA + Sbjct: 114 SDGLFLRCVRDMAQKFPEIQFEEKYLDTVCLNMVQNPGKYDVLVMPNLYGDILSDMCAGL 173 Query: 261 TGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAAC 320 G +G+ PS ++ G L+E G+APDIAGK++ANP A +LS ++LR+ ++ + A Sbjct: 174 VGGLGLTPSGNMGLNG-ALFESVHGTAPDIAGKDLANPTALLLSAVMMLRH-MELNTYAD 231 Query: 321 AIERAINRALEEG-IRTGDLARGAAAVSTDEMGDIIARYV 359 IERA ++EG TGDL A E + I + Sbjct: 232 KIERAAFETIKEGKYLTGDLGGRAK---CSEFTNEICAKL 268 Score = 56.0 bits (134), Expect = 2e-06, Method: Composition-based stats. Identities = 13/55 (23%), Positives = 23/55 (41%), Gaps = 1/55 (1%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMR-ITTSHYDVGGAAIDNHGQ 55 S + ++PGDGIGPE+ K+ A + + + + HG+ Sbjct: 45 SGTKKVTLIPGDGIGPEISAAVQKIFTAANVPIEWEAVDVTPVRLSAIGFEAHGR 99 >UniRef50_UPI0001C163C2 Isocitrate dehydrogenase NADP-dependent, prokaryotic n=3 Tax=Nostocaceae RepID=UPI0001C163C2 Length = 474 Score = 158 bits (401), Expect = 2e-37, Method: Composition-based stats. Identities = 51/247 (20%), Positives = 94/247 (38%), Gaps = 45/247 (18%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRF---AMRITTSHYDVGGAAIDNHGQP-- 56 N + + GDG G ++ KVLDA + +I+ G A D +G Sbjct: 24 PDNPIVPFIRGDGTGIDIWPATEKVLDAAVAKAYNGKRKISWFKVYAGDEACDLYGTYQY 83 Query: 57 LPPATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQG 116 LP T+ ++ + G + P + R + LR+ F L++ +RP + Y G Sbjct: 84 LPQDTLTAIKEYGIAIKGPLTTPIGGGI-------RSLNVALRQIFDLYACVRPCRYYAG 136 Query: 117 LEAFCPLRADIAANGFDILCVRELTGGIYFGQ------------------------PKGR 152 + + + D++ RE T IY G P+ Sbjct: 137 TPS-----PHKSPDKLDVIVYRENTEDIYLGIEWKQGSEIGERLINILNKDLIPATPEHG 191 Query: 153 EGSGQYEKAFDTEVYHRFEIERIARIAFESAR---KRRHKVTSIDKANVLQ-SSILWREI 208 + + + R +R+ R A + A K + +VT + K N+++ + +R+ Sbjct: 192 KKQIPLDAGIGIKPISRSGSQRLVRRALKHALQLPKEKQQVTLVHKGNIMKYTEGAFRDW 251 Query: 209 VNEIATE 215 E+AT+ Sbjct: 252 GYELATQ 258 Score = 140 bits (353), Expect = 8e-32, Method: Composition-based stats. Identities = 45/144 (31%), Positives = 71/144 (49%), Gaps = 6/144 (4%) Query: 219 VELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFG 278 V + D+ Q+ P ++ +L NL GD LSD A I G +GM P A++ + Sbjct: 330 VMVNDRIADSIFQQIQTRPDEYSILATMNLNGDYLSDAAAAIVGGLGMGPGANIGDSC-A 388 Query: 279 LYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGD 338 ++E G+AP AG + NP + ILS ++L Y + +AA I+R + ++ +G T D Sbjct: 389 IFEATHGTAPKHAGLDKINPGSVILSGVMMLEY-MGWQEAADLIKRGLGASIADGKVTYD 447 Query: 339 LAR----GAAAVSTDEMGDIIARY 358 LAR + E D I + Sbjct: 448 LARLMEPPVEPLKCSEFADTIIQQ 471 >UniRef50_A8E541 Idh3a protein n=4 Tax=Euteleostomi RepID=A8E541_DANRE Length = 157 Score = 158 bits (399), Expect = 4e-37, Method: Composition-based stats. Identities = 55/154 (35%), Positives = 82/154 (53%), Gaps = 12/154 (7%) Query: 208 IVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGML 267 I+ I T+ P + + +++DPSQFDVL+ NL+GDILSD CA + G +G+ Sbjct: 12 IMGAIKTQTPQPRV-------FSRGMVQDPSQFDVLVMPNLYGDILSDLCAGLIGGLGVT 64 Query: 268 PSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAIN 327 PS ++ G ++E G+APDIAGK++ANP A +LS ++LR+ + A IE A Sbjct: 65 PSGNIGANGVAIFESVHGTAPDIAGKDMANPTALLLSAVMMLRH-MGLHGHAKKIETACF 123 Query: 328 RALEE-GIRTGDLARGAAAVSTDEMGDIIARYVA 360 + + + T DL E I R V Sbjct: 124 DTIRDKKVLTKDL---GGNPKCSEFTADICRRVQ 154 >UniRef50_Q9LQK9 Putative isocitrate dehydrogenase [NAD] subunit-like 4 n=1 Tax=Arabidopsis thaliana RepID=IDH4_ARATH Length = 294 Score = 157 bits (398), Expect = 5e-37, Method: Composition-based stats. Identities = 73/345 (21%), Positives = 125/345 (36%), Gaps = 67/345 (19%) Query: 19 VMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCEQADAVLFGSVGG 78 V +V+DA++ + Y + G + L V+ + L G V Sbjct: 12 VTNAVHQVMDAMQA----PVYFETYIIKG----KNMNHLTWEVVDSIRKNKVCLNGRV-- 61 Query: 79 PKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRADIAANGFDILCVR 138 RK LF++L G + DI+ +R Sbjct: 62 ------------NNSLCGGARKELDLFASLVDCFNLNGQPS--------RHENVDIVVIR 101 Query: 139 ELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESAR-KRRHKVTSID--- 194 E T G Y G+ + G E T +F +RIA+ AFE A +R KVT++ Sbjct: 102 ENTEGEYAGR-EHEVVPGVIESFQVT--MTKFWSDRIAKYAFEYAHFSKRKKVTAVHNNG 158 Query: 195 KANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILS 254 K L + E E+A YP++ I + + I+ S S I++ Sbjct: 159 KYEKLA-DAFFLESCQEVAKMYPNITYNE--IASRETRAIRRHSN------SKSLWAIIA 209 Query: 255 DECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLD 314 + + + G S + + ++E G N NP+A + S ++LR+ L Sbjct: 210 NIASGVAGG-------SFGDD-YAIFEQVGSVG------NHKNPVALLFSSVMMLRHLL- 254 Query: 315 ADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYV 359 A ++ A+ R + EG G + +T E+ D + + Sbjct: 255 LPLFADRLKTAVTRVISEGKC------GNSNTTTQEVVDSVIANL 293 >UniRef50_Q03UU7 3-isopropylmalate dehydrogenase n=4 Tax=Leuconostoc mesenteroides RepID=Q03UU7_LEUMM Length = 308 Score = 157 bits (398), Expect = 6e-37, Method: Composition-based stats. Identities = 63/297 (21%), Positives = 119/297 (40%), Gaps = 14/297 (4%) Query: 5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEG 64 Y +A+L GD V+ +AL ++ + N + G + + +PLP T+ Sbjct: 2 YKLAILKGDKESSSVIDRALGIIKSSVNDSTA-FEVTELPFGVNGVLSFNEPLPNQTLRE 60 Query: 65 CEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 + D +L G++ + +L+ LRK+ + + ++ PL+ Sbjct: 61 LKNYDGILVGALNQEVGTD---SLLSVQESLVALRKYLNITLACKAVQISDNNVDASPLK 117 Query: 125 ADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESAR 184 I D + V+ + A DT Y + E+E++ FE A Sbjct: 118 NQIV-RDTDFIIVQSAKR----ANDHVDGNISVDDFAQDTITYEQREVEQVITAGFERAM 172 Query: 185 KRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLL 244 R+ VT + + +S +W +IA YPDV + ++ + +I+ P+ DV++ Sbjct: 173 NRKRAVTVVTPFDSFYTSKIWALTAEKIAKIYPDVVVNYVSLSCVISTIIQQPTSLDVVV 232 Query: 245 CSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPD-----IAGKNIA 296 +L++E ITG +P + N G LY+ + D G++ A Sbjct: 233 APKWVDQVLNEESQKITGLPETVPVSMKNNSGQMLYQLPQINVDDKNLMMAVGEDTA 289 >UniRef50_P80046 Isocitrate dehydrogenase [NADP] n=54 Tax=cellular organisms RepID=IDH_SYNY3 Length = 475 Score = 149 bits (377), Expect = 1e-34, Method: Composition-based stats. Identities = 46/246 (18%), Positives = 84/246 (34%), Gaps = 45/246 (18%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRF---AMRITTSHYDVGGAAIDNHGQP-- 56 + I + GDG G ++ V++A + I G A + +G Sbjct: 24 PNDPIIPYIRGDGTGVDIWPATELVINAAIAKAYGGREEINWFKVYAGDEACELYGTYQI 83 Query: 57 LPPATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQG 116 P T+ ++ + G + P + R + LR+ F L++ +RP + Y G Sbjct: 84 FPEDTLTAIKEYGVAIKGPLTTPVGGGI-------RSLNVALRQIFDLYTCVRPCRYYPG 136 Query: 117 LEAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQ------------------- 157 + DI+ RE T IY G G Sbjct: 137 TPS-----PHKTPEKLDIIVYRENTEDIYLGIEWAEGTEGAKKLIAYLNDELIPTTPALG 191 Query: 158 -----YEKAFDTEVYHRFEIERIARIAFESAR---KRRHKVTSIDKANVLQ-SSILWREI 208 + + + +R+ R A A+ K + VT + K N+++ + +R+ Sbjct: 192 KKQIRLDSGIGIKPISKTGSQRLVRRAILHAKRLPKAKQMVTLVHKGNIMKFTEGPFRDW 251 Query: 209 VNEIAT 214 E+AT Sbjct: 252 GYELAT 257 Score = 133 bits (334), Expect = 1e-29, Method: Composition-based stats. Identities = 42/145 (28%), Positives = 68/145 (46%), Gaps = 7/145 (4%) Query: 219 VELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFG 278 V + D+ Q+ P ++ +L NL GD LSD A + G +GM P A++ + Sbjct: 330 VMVNDRIADSIFQQIQTRPDEYSILATMNLNGDYLSDAAAAVVGGLGMGPGANIGDSA-A 388 Query: 279 LYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGD 338 ++E G+AP AG + NP + ILS ++L + + +AA I++ I A+ T D Sbjct: 389 IFEATHGTAPKHAGLDRINPGSVILSGVMMLEF-MGWQEAADLIKKGIGAAIANREVTYD 447 Query: 339 LAR-----GAAAVSTDEMGDIIARY 358 LAR + E I + Sbjct: 448 LARLMEPKVDKPLKCSEFAQAIVSH 472 >UniRef50_B5DZV4 GA24694 n=6 Tax=Drosophila RepID=B5DZV4_DROPS Length = 395 Score = 144 bits (363), Expect = 5e-33, Method: Composition-based stats. Identities = 56/273 (20%), Positives = 112/273 (41%), Gaps = 20/273 (7%) Query: 96 LPLRKHFKLFSNLRPAKLYQGLEAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGS 155 L + L+ + + + G + P DI + + G Y + + Sbjct: 135 LKICNDLDLYVFMTRLRSFPGFKCRFP--------DVDIQVIAQNNIGNYS-ELEYAPVK 185 Query: 156 GQYEKAFDTEVYHRFEIERIARIAFESA-RKRRHKVTSIDKANV-LQSSILWREIVNEI- 212 G E V + + R AFE+A R R +VT I KAN + EI ++ Sbjct: 186 GVVEA---LRVVTHENVTKYLRHAFEAAIRAGRCRVTLIHKANEWPVTDGAMVEIAEKMH 242 Query: 213 ATEYPDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASL 272 A +Y ++L M +D+ +LI DP+ FD + ++ + L+ C+ + G + + L Sbjct: 243 AEDYCSIKLELMELDDCVNRLITDPAYFDTIFTNDRYATFLATICSGVAGGANLFSAIEL 302 Query: 273 NEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEE 332 + +++P + + ++ +P I+S + L + + A ++ + + R + + Sbjct: 303 GDS-HAVFKPLQ-TKLSLTNYSLLSPYG-IVSTCVDLLNHVGQESCAKSLWKGMLRTMTD 359 Query: 333 GIRTG--DLARGAAAVSTDEMGDIIARYVAEGV 363 GI+T D V + M + + E V Sbjct: 360 GIKTVEFDGPDTGEYVICNIMNKLRCSALGENV 392 >UniRef50_C7YNU4 Putative uncharacterized protein n=1 Tax=Nectria haematococca mpVI 77-13-4 RepID=C7YNU4_NECH7 Length = 307 Score = 140 bits (354), Expect = 6e-32, Method: Composition-based stats. Identities = 82/290 (28%), Positives = 135/290 (46%), Gaps = 33/290 (11%) Query: 82 EHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRADIAANGFDILCVRELT 141 + P +PERG LL LRK + ++RP + P + + C R Sbjct: 35 DGAPATSRPERG-LLKLRKEMGTYGSMRPC-FFASDSLVAPQGRGVPRHRL-CHCARAHR 91 Query: 142 GGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARKRR-HKVTSIDKANVLQ 200 + + + + GSG A++TE Y E+ER +A R R K+ S+D ANVL Sbjct: 92 RYLLW---RAQTGSG---SAWNTEPYSHAEVERFTHLAGFLTRGRGDKKLWSLDNANVLA 145 Query: 201 SSILWREIVNEI-ATEYPDVELAHMYIDNATMQLIKDPSQFD-VLLCSNLFGDILSDECA 258 +S WR+++ E E+PD+++ H I++A M ++K+P+ + V++ S LFGDI+SD Sbjct: 146 TSRFWRKVMTETFEKEFPDLKVEHQLINSAVMIMVKNPTGLNGVVVTSTLFGDIISDAAR 205 Query: 259 MITGSMGMLPSASL------NEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYS 312 +I S+G+LPSASL N + +YEP + + A+ S Sbjct: 206 VIPDSIGLLPSASLSGIPDGNRKSNDIYEPIH--VLPLVSRARASSTPSARSC------- 256 Query: 313 LDADDAACAIERAINR--ALEEGIRTGDLARGAAAVSTDEMGDIIARYVA 360 + + ++ R +RT +L GA T E+G+ + V Sbjct: 257 -PWPCFSDTLSTSLRRLWVPPWSLRTKELGGGAN---TKELGEAVINEVI 302 >UniRef50_UPI00017440F3 Isocitrate dehydrogenase (NAD(+)) n=1 Tax=candidate division TM7 single-cell isolate TM7a RepID=UPI00017440F3 Length = 175 Score = 139 bits (350), Expect = 2e-31, Method: Composition-based stats. Identities = 37/173 (21%), Positives = 71/173 (41%), Gaps = 21/173 (12%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 I ++PGDGIG E+ +K+ DA + + + + G + G+ +P + E Sbjct: 3 KITLIPGDGIGYEISESLVKIFDAAK----VPVEFETENAGSDVYEKTGELIPESLYESV 58 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 E+ + G + P + R + LRK + L++N R ++ G+ Sbjct: 59 ERNKIAIKGPITTPIGKGF-------RSINVYLRKKYDLYTNFRSSRNLPGI-------- 103 Query: 126 DIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARI 178 + + D+ RE T GIY G+ K + A + + E + ++ Sbjct: 104 ETRYDNIDLAIFRENTEGIYIGEEKYEN--EEKTSAIAVKRITKKGSEELLKV 154 >UniRef50_A5BNI3 Putative uncharacterized protein n=1 Tax=Vitis vinifera RepID=A5BNI3_VITVI Length = 175 Score = 133 bits (335), Expect = 1e-29, Method: Composition-based stats. Identities = 50/114 (43%), Positives = 66/114 (57%), Gaps = 1/114 (0%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPAT 61 K Y I +LPGDGIGPEV++ A VL + + VGG A+D G PLP T Sbjct: 40 PKRYSITLLPGDGIGPEVISVAKNVLKLAGSLEGIEFGFQEMPVGGCALDLTGVPLPEET 99 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQ 115 + +Q+DAVL G++GG KW+ +PE G LL LR K+F+NLRPA + Sbjct: 100 LLVAKQSDAVLLGAIGGYKWDSNEKHLKPETG-LLQLRSGLKVFANLRPASVLP 152 >UniRef50_D0WIJ5 Isocitrate dehydrogenase, NADP-dependent n=2 Tax=Bacteria RepID=D0WIJ5_9ACTN Length = 434 Score = 129 bits (325), Expect = 1e-28, Method: Composition-based stats. Identities = 74/373 (19%), Positives = 125/373 (33%), Gaps = 56/373 (15%) Query: 36 MRITTSHYDVGGAAIDNHGQPLPPATVEGCEQADAVLFGSVGGPKWEHLPPDQQPE--RG 93 + + T +YD+G A D + + E ++ + + P + + Sbjct: 67 VDLKTEYYDLGLAHRDETDDQVTVDSAEATKRLGVAVKCATITPNAARVEEYDLKRMWKS 126 Query: 94 ALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRADIAANGFDILCVRELTGGIYFGQPKGRE 153 +R P + P + I R G +Y Sbjct: 127 PNGTIRAMLDGTVFRAPIV----VRGIDPCVKNWVRP---ITLARHAYGDVYRDAEMRIP 179 Query: 154 GSGQYEKAFDTEVYHR---------------------FEIERIARIAFESARKRRHKVTS 192 G G E + IE AR F+ A V Sbjct: 180 GPGTVELVYTASDGTETRRLVHEFTEPGVVEGMHNLDASIESFARACFDFALATSQDVWF 239 Query: 193 IDKANVLQS-SILWREIVNEI-----ATEYP--DVELAHMYIDNATMQLIKDPSQFDVLL 244 K + ++ +++I EI A + +E + ID+A +++K F + Sbjct: 240 ATKDTISKTYDHRFKDIFQEIFDADYAARFEAAGIEYFYTLIDDAVARVMKAEGGF-IWA 298 Query: 245 CSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIA------NP 298 C N GD++SD + GS+ M+ S + G+ YE A G+ K++A N Sbjct: 299 CKNYDGDVMSDMVSSAFGSLAMMTSVLASPHGYWEYEAAHGTVQRHYYKHLAGEETSTNS 358 Query: 299 IAQILSLALLLRYSLDAD------DAACAIERAINRALEEGIRTGDLARGA-----AAVS 347 +A I + LR + D A A+E+A +E G TGDLAR +S Sbjct: 359 VATIFAWTGALRKRAELDGLADLAAFADALEQATVATIESGKMTGDLARITSIEHPTKLS 418 Query: 348 TDEMGDIIARYVA 360 T +A + Sbjct: 419 TGAFIKAVAEDLK 431 >UniRef50_A7T3D9 Predicted protein n=2 Tax=cellular organisms RepID=A7T3D9_NEMVE Length = 419 Score = 128 bits (323), Expect = 2e-28, Method: Composition-based stats. Identities = 43/209 (20%), Positives = 76/209 (36%), Gaps = 38/209 (18%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRF---AMRITTSHYDVGGAAID--NHGQP 56 N I + GDGIG ++ +KV+DA + +I+ G A + Sbjct: 26 PNNPIIPFIEGDGIGIDISPVMIKVVDAAVQKAYGGERKISWMEVYAGEKATQVYDQDTW 85 Query: 57 LPPATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQG 116 LP T++ + + G + P + R + LR+ L+ LRP + ++G Sbjct: 86 LPQETLDAVKDYVVSIKGPLTTPVGGGI-------RSLNVALRQQLDLYVCLRPVRWFEG 138 Query: 117 LEAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFD------------- 163 + P++ D+ RE + IY G + + GS + K Sbjct: 139 VP--SPVKK---PGDVDMTIFRENSEDIYAGI-EWKAGSPEATKVIKFLKEEMGVTKIRF 192 Query: 164 -------TEVYHRFEIERIARIAFESARK 185 + + +R+AR A SA Sbjct: 193 DQDCGIGVKPVSKEGTKRLARKALHSAEA 221 >UniRef50_B3MF82 GF11274 n=1 Tax=Drosophila ananassae RepID=B3MF82_DROAN Length = 382 Score = 126 bits (317), Expect = 1e-27, Method: Composition-based stats. Identities = 47/251 (18%), Positives = 96/251 (38%), Gaps = 22/251 (8%) Query: 96 LPLRKHFKLFSNLRPAKLYQGLEAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGS 155 + L L+ + + G P +I + + G+Y + Sbjct: 126 MKLCNDLDLYMFKCRVRSFPGFNCRFP--------DVNIRIIAQNNMGVYSD-LEYSPVK 176 Query: 156 GQYEKAFDTEVYHRFEIERIARIAFESA-RKRRHKVTSIDKAN---VLQSSILWREIVNE 211 G E V + E+ R AF +A + R +VT I K+ + + E Sbjct: 177 GVVEA---ISVSTQEGNEKYLRKAFATAVKANRKRVTLIHKSTEWPI--TDGAMVSAAKE 231 Query: 212 IATEYPD-VELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSA 270 I +Y +EL M +++ +LI P +FD + S+ + +++ C+ I G + + Sbjct: 232 IHKDYEHCLELELMNVEDCIGRLITHPQEFDCIFSSDRYATMIATMCSGICGGANLFSAV 291 Query: 271 SLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRAL 330 + + +++P + I +P + ++ L + L + A+ + R + Sbjct: 292 EIGDF-HAVFKPLQ-VKLSLTNYPILSPYGIVNTIVDLFDH-LGYTECGDALWEQMLRTM 348 Query: 331 EEGIRTGDLAR 341 E GI+T D Sbjct: 349 ESGIKTKDFGG 359 >UniRef50_Q7XZ87 Isocitrate dehydrogenase (Fragment) n=1 Tax=Griffithsia japonica RepID=Q7XZ87_GRIJA Length = 187 Score = 119 bits (299), Expect = 1e-25, Method: Composition-based stats. Identities = 33/167 (19%), Positives = 59/167 (35%), Gaps = 20/167 (11%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPAT 61 S + + + PG G+GPE+ + +A + I + + + Sbjct: 29 SPQFTVTLFPGHGVGPEISVAVQNIFNAA----DVPIVWDEHHIDVDNAKPGQDLISADA 84 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 ++ + L G + P + R L LRK L++N+RP G++ Sbjct: 85 LDSLRRNRFGLKGPMATPIG-------KGYRSLNLTLRKALGLYANVRPCVSIPGVQT-- 135 Query: 122 PLRADIAANGFDILCVRELTGGIYFG-QPKGREGSGQYEKAFDTEVY 167 + D++ VRE T G Y G + G + K E Sbjct: 136 ------PYDDVDVVTVRENTEGEYSGLEHVVYPGVVESLKVITPERV 176 >UniRef50_B6QRT7 3-isopropylmalate dehydrogenase, putative n=1 Tax=Penicillium marneffei ATCC 18224 RepID=B6QRT7_PENMQ Length = 158 Score = 116 bits (290), Expect = 2e-24, Method: Composition-based stats. Identities = 47/136 (34%), Positives = 75/136 (55%), Gaps = 4/136 (2%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDA-VRNRFAMRITTSHYDVGGAAIDNHGQPLPP 59 M++ + VL GD IGPE++ +ALK L V R ++ + + GA++D +P+ Sbjct: 1 MAEIRKLLVLRGDRIGPEIIAEALKPLTVLVEERPDFKVQVRYGLLAGASLDKTNEPITD 60 Query: 60 ATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKL-YQGLE 118 ++ DAVL GSVG P+W H+P PE+G +L LR+ F+N+RP + L Sbjct: 61 KVLDAALATDAVLLGSVGEPEWAHMPGALNPEKG-ILRLRQRLDAFANIRPCRFCASSLV 119 Query: 119 AFCPLRADIAANGFDI 134 PL++D+ NG + Sbjct: 120 EQSPLKSDMV-NGVNF 134 >UniRef50_Q0CXI1 Isocitrate dehydrogenase, mitochondrial n=2 Tax=Eurotiomycetidae RepID=Q0CXI1_ASPTN Length = 466 Score = 113 bits (283), Expect = 1e-23, Method: Composition-based stats. Identities = 74/374 (19%), Positives = 118/374 (31%), Gaps = 60/374 (16%) Query: 42 HYDVGGAAIDNHGQPLPPATVEGCEQADAVLFGSVGGPKWEHLPPDQQPER--GALLPLR 99 H G D + E ++ + + P + + + +R Sbjct: 97 HRPQGIEYRDQTDDKVTVEAAEAIKKYGVGVKCATITPDEARVEEFKLKKMWLSPNGTIR 156 Query: 100 KHFKLFSNLRPAKLYQGLEAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYE 159 P + + P I+ R G Y + G G+ E Sbjct: 157 NILGGTVFREPI-VIPAIPRLVPGWTKP------IIIGRHAFGDQYRATDRVIPGPGKLE 209 Query: 160 KAF--------DTEVY--------------HRFEIERIARIAFESARKRRHKVTSIDKAN 197 + +VY I A +F+ A + + K Sbjct: 210 LVYTPANGQPESVQVYDFQSGGGVAMSMYNTDDSIRGFAHSSFKMALLKGLPLYMSTKNT 269 Query: 198 VLQ-SSILWREIVNEI-ATEYP------DVELAHMYIDNATMQLIKDPSQFDVLLCSNLF 249 +L+ +++I EI EY + H ID+ Q+IK F ++ N Sbjct: 270 ILKRYDGRFKDIFQEIYEAEYKKEFDAKGIWYEHRLIDDMVAQMIKSEGGF-IMALKNYD 328 Query: 250 GDILSDECAMITGSMGMLPSASLNEQGFGLY-EPAGGSAPDIA-----GKNIA-NPIAQI 302 GD+ SD A GS+G++ S G E A G+ G+ + NPIA I Sbjct: 329 GDVQSDIVAQGFGSLGLMTSTLTTPDGSAFESEAAHGTVTRHYREHQKGRETSTNPIASI 388 Query: 303 LSLA------LLLRYSLDADDAACAIERA-INRALEEGIRTGDLARGAAA------VSTD 349 + L + D A +ERA I EEGI T DLA V+T Sbjct: 389 FAWTRGLVQRGQLDNTPDVVTFAEELERACIEVVNEEGIMTKDLALSCGRKEREAWVTTR 448 Query: 350 EMGDIIARYVAEGV 363 E + R + + Sbjct: 449 EYMAAVERRLKANL 462 >UniRef50_Q0V3G8 Putative uncharacterized protein n=1 Tax=Phaeosphaeria nodorum RepID=Q0V3G8_PHANO Length = 376 Score = 109 bits (274), Expect = 1e-22, Method: Composition-based stats. Identities = 74/383 (19%), Positives = 132/383 (34%), Gaps = 58/383 (15%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCE 66 + L GD E+ +V+ + I +YD+G D + E + Sbjct: 16 VVELDGD----EMTRIIWQVIKDKFIHPYLDIDLKYYDLGLEYRDETNDQVTLDAAEAIK 71 Query: 67 QADAVLFGSVGGPKWEHLPPDQQPER--GALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 + + + P + + + + +R H P + + P Sbjct: 72 KYSVGVKCATITPDEQRVEEFKLKKMWLSPNGTIRNHLGGTVFRAPI-VIPAIPRLVPSW 130 Query: 125 ADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESAR 184 I+ R G Y + + + G E F + + E+ ++ E Sbjct: 131 KQP------IIIGRHAFGDQYRAKDRVIDTEGTLEMVFTPK-GGKPEVIKVYDFPAE--- 180 Query: 185 KRRHKVTSIDKANVLQSSILWREIVNEIAT-------EYPDVELAHMYIDNATMQLIKDP 237 V Q+ +++I EI E + H ID+ Q+IK Sbjct: 181 -----------GGVAQTQ--FKDIFQEIYEAQYRKEFEAAGIWYEHRLIDDMVAQMIKSE 227 Query: 238 SQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLY-EPAGGSAPDIA----- 291 + ++ N GD+ SD A GS+G++ S + G E A G+ Sbjct: 228 GGY-IIAMKNYDGDVQSDIVAQGFGSLGLMTSVLITPDGKTFEAEAAHGTVTRHYREHQK 286 Query: 292 GKNIA-NPIAQILSLALLLRYSLDADDA------ACAIERA-INRALEEGIRTGDLARGA 343 G+ + NPIA I + L + D+ A +E+A ++ E+GI T DLA Sbjct: 287 GRETSTNPIASIYAWTQGLIKRGELDNTPELVVFAEQLEKACVDTVNEDGIMTKDLALAQ 346 Query: 344 AA------VSTDEMGDIIARYVA 360 V+T+E D + R + Sbjct: 347 GKKDRSAWVTTNEYLDAVERRLK 369 >UniRef50_O75874 Isocitrate dehydrogenase [NADP] cytoplasmic n=362 Tax=cellular organisms RepID=IDHC_HUMAN Length = 414 Score = 106 bits (266), Expect = 1e-21, Method: Composition-based stats. Identities = 72/389 (18%), Positives = 127/389 (32%), Gaps = 61/389 (15%) Query: 1 MSKNYH---IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPL 57 MSK + + GD E+ +++ + + YD+G D + Sbjct: 1 MSKKISGGSVVEMQGD----EMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQV 56 Query: 58 PPATVEGCEQADAVLFGSVGGPKWEHLPPDQQPE--RGALLPLRKHFKLFSNLRPAKLYQ 115 E ++ + + + P + + + + + +R R A + + Sbjct: 57 TKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTV-FREAIICK 115 Query: 116 GLEAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRF----- 170 + I+ R G Y G G+ E + + Sbjct: 116 NIPRLVSGWVKP------IIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLV 169 Query: 171 ------------------EIERIARIAFESARKRRHKVTSIDKANVLQS-SILWREIVNE 211 IE A +F+ A + + K +L+ +++I E Sbjct: 170 HNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQE 229 Query: 212 I-ATEYPD------VELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSM 264 I +Y + H ID+ Q +K F + C N GD+ SD A GS+ Sbjct: 230 IYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGF-IWACKNYDGDVQSDSVAQGYGSL 288 Query: 265 GMLPSASLNEQGFGLY-EPAGGSAPDIA-----GKNIA-NPIAQILSLALLLRYSLDADD 317 GM+ S + G + E A G+ G+ + NPIA I + L + D+ Sbjct: 289 GMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDN 348 Query: 318 ------AACAIERAINRALEEGIRTGDLA 340 A A+E +E G T DLA Sbjct: 349 NKELAFFANALEEVSIETIEAGFMTKDLA 377 >UniRef50_C7GAF7 3-isopropylmalate dehydrogenase (Fragment) n=1 Tax=Roseburia intestinalis L1-82 RepID=C7GAF7_9FIRM Length = 115 Score = 104 bits (261), Expect = 4e-21, Method: Composition-based stats. Identities = 49/113 (43%), Positives = 65/113 (57%), Gaps = 5/113 (4%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 I V+ GDGIGPE++ +A KVLD + ++ +GG +ID G PL + Sbjct: 4 KIGVISGDGIGPEIVAEAKKVLDKIGTKYGHSFLYEAILMGGCSIDATGVPLTDEAIAAA 63 Query: 66 EQADAVLFGSVGG----PKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLY 114 + +DAVL GS+GG W L P+ +PE G LL LRK LF+NLRPA LY Sbjct: 64 KASDAVLMGSIGGNTATSPWYKLAPELRPEAG-LLKLRKSLNLFANLRPAYLY 115 >UniRef50_P48735 Isocitrate dehydrogenase [NADP], mitochondrial n=656 Tax=cellular organisms RepID=IDHP_HUMAN Length = 452 Score = 103 bits (257), Expect = 1e-20, Method: Composition-based stats. Identities = 68/374 (18%), Positives = 125/374 (33%), Gaps = 45/374 (12%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCE 66 + + GD E+ + + + I ++D+G D + + + Sbjct: 50 VVEMDGD----EMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQ 105 Query: 67 QADAVLFGSVGGPKWEHLPPDQ--QPERGALLPLRKHFKLFSNLRPA------KLYQGLE 118 + + + P + + + + +R P +L G Sbjct: 106 KYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPRLVPGWT 165 Query: 119 AFCPLRADIAANG---FDILCVRELTGGIYFGQPKGREGSGQYEK------AFDTEVY-H 168 + + D + R T + F PK G ++E +Y Sbjct: 166 KPITIGRHAHGDQYKATDFVADRAGTFKMVF-TPKDGSGVKEWEVYNFPAGGVGMGMYNT 224 Query: 169 RFEIERIARIAFESARKRRHKVTSIDKANVLQS-SILWREIVNEIATEY-------PDVE 220 I A F+ A +++ + K +L++ +++I EI ++ + Sbjct: 225 DESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDFDKNKIW 284 Query: 221 LAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLY 280 H ID+ Q++K F V C N GD+ SD A GS+G++ S + G + Sbjct: 285 YEHRLIDDMVAQVLKSSGGF-VWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIE 343 Query: 281 -EPAGGSAPDIA---GKNI---ANPIAQILSLALLLRYSLDAD------DAACAIERAIN 327 E A G+ K NPIA I + L + D A +E+ Sbjct: 344 AEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQMLEKVCV 403 Query: 328 RALEEGIRTGDLAR 341 +E G T DLA Sbjct: 404 ETVESGAMTKDLAG 417 >UniRef50_B6KL81 Isocitrate dehydrogenase, putative n=6 Tax=cellular organisms RepID=B6KL81_TOXGO Length = 594 Score = 103 bits (256), Expect = 2e-20, Method: Composition-based stats. Identities = 71/375 (18%), Positives = 116/375 (30%), Gaps = 61/375 (16%) Query: 36 MRITTSHYDVGGAAIDNHGQPLPPATVEGCEQADAVLFGSVGGPKWEHLPPDQ--QPERG 93 + I +YD+ D + ++ + + P + + + + Sbjct: 213 LDIPLMYYDLSIQHRDKTDDQVTIDAALAIKRHGVGVKCATITPDEQRVKEFNLKKMWKS 272 Query: 94 ALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRADIAANGFDILCVRELTGGIYF------- 146 +R P L + + P I+ R Y Sbjct: 273 PNATIRNTLDGTIFRAPI-LMKNVPRLVPSWTKP------IIIGRHAHADQYKALDFTVD 325 Query: 147 --------------GQPKGREGSGQYEKAFDTEVY-HRFEIERIARIAFESARKRRHKVT 191 P+ E +Y I+ A F+ A ++ + Sbjct: 326 KPGRFVMSFIPADKSNPEVHEVYEFKGGGVALGMYNTDASIKGFAHSCFQYALDQKMPLY 385 Query: 192 SIDKANVLQS-SILWREIVNEI-ATEY------PDVELAHMYIDNATMQLIKDPSQFDVL 243 K VL+ +++I I EY + H ID+ Q IK F V Sbjct: 386 LSTKNTVLKKYDGRFKDIFQTIYEKEYKQKFEEAGLWYEHRLIDDMVAQAIKSSGGF-VW 444 Query: 244 LCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLY-EPAGGSAPDI---AGKNI---A 296 C N GD+ SD A GS+G++ S + G + E A G+ K I Sbjct: 445 ACKNYDGDVQSDVVAQGYGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYRQYQKGIKTST 504 Query: 297 NPIAQILSLALLLRYSLDAD------DAACAIERAINRALEEGIRTGDLA--------RG 342 NPIA I + L + D + A+E A +E G T DLA Sbjct: 505 NPIASIYAWTRSLGHRAKLDNNQKLKEFVEALEDACVETVEAGFMTKDLALAIKGDKLTD 564 Query: 343 AAAVSTDEMGDIIAR 357 + T++ D +AR Sbjct: 565 RDYLCTEDFMDKLAR 579 >UniRef50_B1XUL5 Tartrate dehydrogenase n=1 Tax=Polynucleobacter necessarius subsp. necessarius STIR1 RepID=B1XUL5_POLNS Length = 120 Score = 101 bits (253), Expect = 3e-20, Method: Composition-based stats. Identities = 46/123 (37%), Positives = 62/123 (50%), Gaps = 11/123 (8%) Query: 245 CSNLFGDILSDECAMITGSMGMLPSASLNEQG--FGLYEPAGGSAPDIAGKNIANPIAQI 302 N+FGDILSD TG++ + PS S+N +G L+EP GS PDI GK IANPI Q+ Sbjct: 1 MPNVFGDILSDLGPACTGTIAVAPSGSINPEGKFPSLFEPVHGSTPDIFGKMIANPIGQM 60 Query: 303 --LSLALLLRYSLDADDAACAIERAINRALEEG----IRTGDLARGAAAVSTDEMGDIIA 356 + ++ L + AI I + L G T DL A TD++G IA Sbjct: 61 ARFGVGAMILDHLGYPETGKAIFSVIEKVLSSGAGNAPLTPDLGGSAK---TDDLGKAIA 117 Query: 357 RYV 359 + Sbjct: 118 AAI 120 >UniRef50_Q6L1Z1 Isocitrate dehydrogenase [NADP] n=1 Tax=Picrophilus torridus RepID=Q6L1Z1_PICTO Length = 355 Score = 101 bits (251), Expect = 6e-20, Method: Composition-based stats. Identities = 59/374 (15%), Positives = 137/374 (36%), Gaps = 45/374 (12%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRF---AMRITTSHYDVGGAAIDNHGQPL 57 + + I + GDG G E+ + +++ + I +G A + +G+ L Sbjct: 12 IPDDVTIGYIEGDGEGTELTRAMINAVNSAIEIAYSGSKSIEWKKIYIGREAYEKYGKYL 71 Query: 58 PPATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGL 117 P ++E + V+ G + + +++ L+++++ GL Sbjct: 72 PRESIEDIRKTVFVMKGPL---------SSNINGHDININIKRILNLYTDVKCITGLPGL 122 Query: 118 EA------FCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFE 171 F P ++ +D + + + S D++++ + Sbjct: 123 SEGKEIFIFSPSIDEVYHFSYD-------SEDS-DMLRQYLQQSFNISIGGDSDIFLKGT 174 Query: 172 IE-RIARIAFESA----RKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYI 226 RI +IA + A + D + + +N++ E P VE+ ++Y Sbjct: 175 SRYRIIKIASKIAEISSLYGIKRTLVADDYTGSHAPLWVYNTLNKM--EMP-VEIENLY- 230 Query: 227 DNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGS 286 + S+F++ + + ++ T A L + L+E Sbjct: 231 --NLYDEMTSESRFNIFIPDSRLSSLIIKIINART-----FFGAILGDF-ISLFESQSRP 282 Query: 287 APDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAV 346 + G ++A+P + +L+ +++LR L+ +DAA + A+N +GI L + Sbjct: 283 SFTEEGYDLADPTSFLLASSMMLR-RLNFNDAALILRNALNSVYSDGILPASLNLNNG-L 340 Query: 347 STDEMGDIIARYVA 360 + D I + + Sbjct: 341 KCSDFIDAIVKRMK 354 >UniRef50_P50217 Isocitrate dehydrogenase [NADP] n=49 Tax=cellular organisms RepID=IDHC_SOLTU Length = 416 Score = 100 bits (249), Expect = 1e-19, Method: Composition-based stats. Identities = 72/411 (17%), Positives = 130/411 (31%), Gaps = 71/411 (17%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCE 66 I + GD E+ K + + + ++ +G D + + E + Sbjct: 12 IVEMDGD----EMTRVIWKSIKDKLILPFLELDIKYFSLGLPHRDATDDKVTVESAEATQ 67 Query: 67 QADAVLFGSVGGPKWEHLPPDQQPE--RGALLPLRKHFKLFSNLRP--AKLYQGLEAFCP 122 + + + + P + R +R P K L Sbjct: 68 KYNVAIKCATITPDEARVKEFNLKSMWRSPNGTIRNILNGTVFREPIMCKNIPRLVPGWT 127 Query: 123 LRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAF---------DTEVY------ 167 I R G Y +G+G+ + F + EVY Sbjct: 128 KP---------ICIGRHAFGDQYRATDTVIKGAGKLKLVFVPEGSDEKTEFEVYNFTGAG 178 Query: 168 --------HRFEIERIARIAFESARKRRHKVTSIDKANVLQS-SILWREIVNEI-----A 213 + A + A +++ + K +L+ +++I E+ Sbjct: 179 GVALSMYNTDESVRSFAEASMNMAFQKKWPLYLSTKNTILKKYDGRFKDIFQEVYEANWK 238 Query: 214 TEYPD--VELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSAS 271 ++Y + + H ID+ +K + V C N GD+ SD A GS+G++ S Sbjct: 239 SKYEEAGIWYEHRLIDDMVAYALKSEGGY-VWACKNYDGDVQSDFLAQGFGSLGLMTSVL 297 Query: 272 LNEQGFGLY-EPAGGSAPDIA------GKNIANPIAQILSLALLLRYSLDAD------DA 318 + G + E A G+ G+ N IA I + L + D D Sbjct: 298 VCPDGKTIEAEAAHGTVTRHYRVHQKGGETSTNSIASIFAWTRGLAHRATLDNNERLLDF 357 Query: 319 ACAIERAINRALEEGIRTGDLA---------RGAAAVSTDEMGDIIARYVA 360 +E A A+E G T DLA ++T+E D +A + Sbjct: 358 TEKLEAACIGAVESGKMTKDLALIIIHGSKLSREHYLNTEEFIDAVADELK 408 >UniRef50_C1GSN2 3-isopropylmalate dehydrogenase n=4 Tax=Onygenales RepID=C1GSN2_PARBA Length = 542 Score = 95.3 bits (236), Expect = 3e-18, Method: Composition-based stats. Identities = 38/102 (37%), Positives = 53/102 (51%), Gaps = 1/102 (0%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 + I VL GDGIG E+ +A+KVL A + + G +ID G P+ ++ Sbjct: 362 THTILVLRGDGIGLEITAEAVKVLSAFSLK-KRTFDLRSELIDGCSIDTDGTPITKTVIQ 420 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLF 105 +DAVLF SVGGPKW+ + D + G LL LRK + Sbjct: 421 AALDSDAVLFASVGGPKWDGVRHDLEGPEGGLLQLRKAMNQW 462 >UniRef50_A2Q9Q7 Contig An01c0300, complete genome n=6 Tax=Trichocomaceae RepID=A2Q9Q7_ASPNC Length = 565 Score = 95.3 bits (236), Expect = 3e-18, Method: Composition-based stats. Identities = 59/381 (15%), Positives = 127/381 (33%), Gaps = 51/381 (13%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATV 62 + + + G G G E++ +V+ + ++++ + H + Sbjct: 4 QTVRLGLAVGHGTGRELVAVFERVIQTLAKQYSVNFEFVRSSSTYHSY--HTLTVSGEDK 61 Query: 63 EGCEQA------DAV----LFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAK 112 DA+ + G + + L +R+H + + + Sbjct: 62 NLITHIADETTKDAIDYQQFCENAAGSGIAAIFRTAIHAQSLYL-VRQHLQA-AKVEHFS 119 Query: 113 LYQGLEAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEI 172 L G +L VR+ G Y G + T + + Sbjct: 120 LGDGNA---------------LLMVRDEAQGFYAGDNTYSADQLSITR---TTSFSKPVF 161 Query: 173 ERIARIAFESARKR------RHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYI 226 +RI R A + A + KVT K ++ +++ + ++ ++ + Sbjct: 162 DRIIRFALDRAAENWGPENVPKKVTMAYKFHLF--DGVFQAWEPQWKAQF-GIDFDFIQP 218 Query: 227 DNATMQLIKDP-SQFDVLLCSNLFGDILSDECAMITG--SMGMLPSASL----NEQGFGL 279 D L+ + +++ N + D++ G + + + ++ + G Sbjct: 219 DTLNRSLMANGVQGRCIIIAGNEYADVIQPVFLNWFGQSTPETMYAENVYLRPDVNGLSE 278 Query: 280 YEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDL 339 Y+ GSA IA K + NP A I + A +L E+AI L+ + T D Sbjct: 279 YQTVHGSADAIADKGLVNPFATIRAAAAILERHAGGKGIQKLTEQAIQSLLQRKLTTPD- 337 Query: 340 ARGAAAVSTDEMGDIIARYVA 360 ++ T+E D + +A Sbjct: 338 --QGGSLKTEETVDHFLQAIA 356 >UniRef50_A1D5P0 Isocitrate dehydrogenase family protein n=4 Tax=Trichocomaceae RepID=A1D5P0_NEOFI Length = 558 Score = 92.6 bits (229), Expect = 2e-17, Method: Composition-based stats. Identities = 67/373 (17%), Positives = 120/373 (32%), Gaps = 45/373 (12%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAID-----NHGQ 55 MS + + + G+G GPE+ +V+ ++ R+ + +T + N Sbjct: 1 MS-SIQVGLAVGNGTGPELTAIFERVIQSLAARYNVSVTFLRSPRIYNSYSSLLAINDAD 59 Query: 56 PLPPATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQ 115 + T+ +V + AL +R+ Sbjct: 60 AVTEETLSDAAHYRQFCKEAVSCGVRAIFRTSISAQ--ALYLVREQL------------- 104 Query: 116 GLEAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERI 175 + + IL VR+ G Y G + + T + + RI Sbjct: 105 ---QAIKVEHFTLSPTSSILLVRDQAQGFYSG---TNSVNTSKDAVSRTAHFSKAIFARI 158 Query: 176 ARIAFESARK---RRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQ 232 A A + + VT + K ++ L+ E + V + + D Sbjct: 159 LSYALGRANQLWGGTNSVTMVYKFHLF--DGLFHTWATEWERTF-GVNIRFVQGDTMNRD 215 Query: 233 LIK-DPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNE-------QGFGLYEPAG 284 L+ S ++L+ N + DI+ G +G SA QG Y+ A Sbjct: 216 LLAFGVSGHNLLISGNEYADIMQTILLDRFG-LGAQESACAENVYLHPDVQGLSEYQTAH 274 Query: 285 GSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAA 344 GSA D+ GK I NP A I + A +L ++ + GI T D Sbjct: 275 GSADDLLGKGIVNPTATIRAAAAVLEDQAGCSGLKQRVDCVLGDLGARGIGTPD---QGG 331 Query: 345 AVSTDEMGDIIAR 357 +T+ + + Sbjct: 332 TATTERFVEAFLQ 344 >UniRef50_Q8KH40 LeuB (Fragment) n=3 Tax=Buchnera aphidicola RepID=Q8KH40_9ENTR Length = 95 Score = 91.5 bits (226), Expect = 5e-17, Method: Composition-based stats. Identities = 44/85 (51%), Positives = 61/85 (71%), Gaps = 1/85 (1%) Query: 280 YEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDL 339 YEPAGGSAPDIAGKNIANPIAQILS+A+L+RY++ + IE A+ L++G RT D+ Sbjct: 11 YEPAGGSAPDIAGKNIANPIAQILSIAMLVRYTMKLPIISDQIESAVIDTLKKGYRTLDI 70 Query: 340 ARGAAAV-STDEMGDIIARYVAEGV 363 A ST+++GDII+ + + + Sbjct: 71 ANDKEKCESTNDIGDIISYILKKRI 95 >UniRef50_Q1G324 Putative uncharacterized protein n=1 Tax=Arabidopsis thaliana RepID=Q1G324_ARATH Length = 130 Score = 89.2 bits (220), Expect = 2e-16, Method: Composition-based stats. Identities = 32/77 (41%), Positives = 45/77 (58%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPAT 61 K Y IAVLPGDG+G EV+ A+ VL + + + +GG A+D G PLP T Sbjct: 38 KKRYTIAVLPGDGVGNEVIPVAVDVLCLAGSLEGIDFSFEELPIGGVALDLVGVPLPKET 97 Query: 62 VEGCEQADAVLFGSVGG 78 + +Q+DA+L G+VG Sbjct: 98 LIRAKQSDALLLGAVGW 114 >UniRef50_C5FHL7 Isocitrate dehydrogenase family protein n=1 Tax=Microsporum canis CBS 113480 RepID=C5FHL7_NANOT Length = 579 Score = 88.0 bits (217), Expect = 5e-16, Method: Composition-based stats. Identities = 69/377 (18%), Positives = 116/377 (30%), Gaps = 52/377 (13%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 I V G G GPE+ T V+ + +R+++ + D + ++ PL + Sbjct: 8 RIGVAIGHGTGPELATVFEHVVRELASRYSLGVEFVRSDRIYHSYNS--LPLADESQNA- 64 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 P + L R A Q L A Sbjct: 65 ------------TPDICDETVNDITHYQQFCEQEASRGLKVIFRTAISAQSLYAVRQQLE 112 Query: 126 DIAANGFD-----ILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEI-ERIARIA 179 + FD +L +R+ G Y G K + R + + I + Sbjct: 113 AVKVECFDRGTSSLLVIRDQAQGFYTGTNKLESDQDSVSRVCHF----RKGVFQHIIAFS 168 Query: 180 FESARKR-------RHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQ 232 E AR++ V + K ++ L + E+ +++ + D Sbjct: 169 LERAREKWGYDLGGIKSVFLVYKFHLF--DGLLLSWARDWTKEF-GIKVEFIQPDTMNRN 225 Query: 233 LIKDPSQFDV----LLCSNLFGDILSDECAMITGSMGMLPSASLNE------QGFGLYEP 282 LI F V ++ N + DI+ S S N Y+ Sbjct: 226 LI----AFGVHRCLMIAGNEYADIMQTIFLEKFNMRVQETSCSENVYLKPVLNRLSEYQT 281 Query: 283 AGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARG 342 GSA DI GK I NP A I + A +L ++ +N + T D Sbjct: 282 THGSADDITGKGIVNPSATIRAAAAILERFGGCVGIDAKVDDTLNILQKNKSGTPD---Q 338 Query: 343 AAAVSTDEMGDIIARYV 359 ++T D+ R + Sbjct: 339 GGNLTTAAFVDVFLRTL 355 >UniRef50_Q8T494 AT08722p n=1 Tax=Drosophila melanogaster RepID=Q8T494_DROME Length = 218 Score = 86.8 bits (214), Expect = 1e-15, Method: Composition-based stats. Identities = 50/203 (24%), Positives = 87/203 (42%), Gaps = 17/203 (8%) Query: 146 FGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA-RKRRHKVTSIDKANVLQ---- 200 F + + G E V + ++ R AF++A + R +VT I+KA + Sbjct: 4 FNELEYSPVEGVVEA---LSVVSQKGNDKYLRYAFKAAAKAGRKRVTLINKA---KEWPI 57 Query: 201 SSILWREIVNEIATEYPD-VELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAM 259 S E + Y D +EL M ++ A +L+ +P+ FD L S + LS C+ Sbjct: 58 SDGSLVEAAQRLHCHYKDCLELELMEVEEAISRLMTEPTYFDCLFASERYATFLSAICSG 117 Query: 260 ITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIA-QILSLALLLRYSLDADDA 318 + G + + + + +++P ++ N AN A I+S + L L D Sbjct: 118 VCGGANLFSAVEIGDH-HAVFKPLQT---KLSLTNYANLSAYGIVSTIVDLFQHLGHDKC 173 Query: 319 ACAIERAINRALEEGIRTGDLAR 341 A A+ + R + EGIRT + Sbjct: 174 ADALWCELKRTMNEGIRTKEFGG 196 >UniRef50_Q567A6 Isocitrate dehydrogenase 3 (NAD+) gamma n=1 Tax=Danio rerio RepID=Q567A6_DANRE Length = 289 Score = 86.1 bits (212), Expect = 2e-15, Method: Composition-based stats. Identities = 25/139 (17%), Positives = 51/139 (36%), Gaps = 20/139 (14%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 + + ++PGDGIGPE +L+ VR F ++V + + + Sbjct: 50 RHTVTLIPGDGIGPE-------LLNHVRELFRFSCVPVDFEVVHVNSSSTSEDDISNAIM 102 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 + L G++ +PP+ + LR L++N+ + G++ Sbjct: 103 AIRRNGVALKGNIET--NHTMPPNHKSRNNL---LRTSLDLYANVMHCQSLPGVQT---- 153 Query: 124 RADIAANGFDILCVRELTG 142 DI+ + E + Sbjct: 154 ----RHKNIDIIIILEKSE 168 >UniRef50_Q84AT8 LeuB (Fragment) n=1 Tax=Buchnera aphidicola RepID=Q84AT8_9ENTR Length = 81 Score = 84.5 bits (208), Expect = 5e-15, Method: Composition-based stats. Identities = 40/81 (49%), Positives = 58/81 (71%), Gaps = 1/81 (1%) Query: 284 GGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLAR-G 342 GGSAPDIAGKNIANPIAQILS+A+L+RY++ A IE ++ AL++G +T D+A Sbjct: 1 GGSAPDIAGKNIANPIAQILSIAMLVRYTMKLHKIADDIESSVIDALKKGYKTLDIANVN 60 Query: 343 AAAVSTDEMGDIIARYVAEGV 363 +ST +MGD+I+ + + + Sbjct: 61 ETHISTSDMGDVISNILNKRI 81 >UniRef50_Q8N9Z6 cDNA FLJ36019 fis, clone TESTI2016421, highly similar to PROTEIN KINASE C-BINDING PROTEIN NELL1 n=1 Tax=Homo sapiens RepID=Q8N9Z6_HUMAN Length = 355 Score = 83.0 bits (204), Expect = 2e-14, Method: Composition-based stats. Identities = 24/115 (20%), Positives = 46/115 (40%), Gaps = 16/115 (13%) Query: 98 LRKHFKLFSNLRPAKLYQGLEAFCPLRADIAANGFDILCVRELTGGIYFG-QPKGREGSG 156 L L++++ K +E + DIL V E T G Y + + +G Sbjct: 2 LHTTLDLYASVIHLKNLPNVETW--------HKDVDILVVWENTEGEYSNLEHESVKGVT 53 Query: 157 QYEKAFDTEVYHRFEIERIARIAFESARKRR-HKVTSIDKANVLQ-SSILWREIV 209 + ++ + + RIA AF+ A+K KV ++ K N+ + + + Sbjct: 54 E-----SLKIMTKAKSLRIAEYAFQLAQKMGCKKVMAVHKVNITKLGDGPFLQCC 103 >UniRef50_B6QD56 Putative uncharacterized protein n=1 Tax=Penicillium marneffei ATCC 18224 RepID=B6QD56_PENMQ Length = 106 Score = 82.6 bits (203), Expect = 2e-14, Method: Composition-based stats. Identities = 26/78 (33%), Positives = 41/78 (52%), Gaps = 1/78 (1%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFA-MRITTSHYDVGGAAIDNHGQPLPPAT 61 K Y IA +PGD IGPEV+ + VL +++ + R+ + D G A G+ +P Sbjct: 7 KTYKIASIPGDDIGPEVVNVIIDVLKSLQEILSTYRLEFTELDWGTARYKRTGKYMPADG 66 Query: 62 VEGCEQADAVLFGSVGGP 79 + + A +FG+VG P Sbjct: 67 LSTLKTFHAGIFGAVGAP 84 >UniRef50_A4SBK5 Predicted protein n=6 Tax=Eukaryota RepID=A4SBK5_OSTLU Length = 409 Score = 80.7 bits (198), Expect = 9e-14, Method: Composition-based stats. Identities = 67/404 (16%), Positives = 135/404 (33%), Gaps = 72/404 (17%) Query: 16 GPEVMTQALKVLDA--VRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCEQADAVLF 73 G E+ + ++ A + R +D+ D+ + +E + A+ Sbjct: 18 GEEMTAYVMDLIRAKWIEPRVD-TTAWREFDLRAKNRDDTEDQVLRDVIEAGKAVKAIFK 76 Query: 74 GSVGGPKWEHLP--PDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRADIAANG 131 P + + ++ +R+ + + R G+E + + Sbjct: 77 EPTVTPTADQVKRLGLRKSWGSPNGAMRRGWNGITISRDTIHIDGVELGY--KKPVFFE- 133 Query: 132 FDILCVRELTGGIYF------GQPKGREGSGQYE-------KAFDTEVYHRFE------- 171 R GG Y G+ E D+ E Sbjct: 134 ------RHAVGGEYAAGYKNVGKGTLVTTFTPSEGPDAGKPVEVDSRTITDNEAAVVTYH 187 Query: 172 -----IERIARIAFESARKRRHKVTSIDKANVLQSSILWREIVNEI-ATEYP-------- 217 + +AR F + + + K V + + +I+ ++ EY Sbjct: 188 NPYDNVHELARFFFGRCLEAKITPYVVTKKTVFKWQEPFWQIMKKVFDEEYKSKFVDAGV 247 Query: 218 ---DVELAHMYIDNATMQLIK-DPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLN 273 EL H+ D ATM+L++ F + N GD+L+DE A I S G + S + Sbjct: 248 MKSGDELVHLLSDAATMKLVQWRQGGFG-MAAHNYDGDVLTDELAQIHKSPGFITSNLVG 306 Query: 274 EQGFGL----YEPAGGSAPD-----IAGKNIA-NPIAQILSLALLLRYSLDADDAAC--- 320 G +E + G+ D + G+ + NP+ + L + ++ D + Sbjct: 307 VDENGTLIKEFEASHGTVADMDEARLRGEETSLNPLGMVEGLIGAMNHAADVHNVDKERT 366 Query: 321 -----AIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYV 359 + I++ EG T DL+ + ++T++ D +A + Sbjct: 367 LAFTAKMRAVIHQLFREGKGTRDLSGPSG-LTTEQFVDAVAERL 409 >UniRef50_A3RRN5 Tartrate dehydrogenase n=3 Tax=Ralstonia solanacearum RepID=A3RRN5_RALSO Length = 95 Score = 79.9 bits (196), Expect = 1e-13, Method: Composition-based stats. Identities = 31/81 (38%), Positives = 42/81 (51%), Gaps = 2/81 (2%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYD-VGGAAIDNHGQPLPP 59 MS +Y IAV+PGDGIG E + + L+V DA RF + H+D HG+ P Sbjct: 1 MS-SYRIAVIPGDGIGKEAVPERLRVPDAAARRFGFALHCGHFDFASSDTRARHGKLRPD 59 Query: 60 ATVEGCEQADAVLFGSVGGPK 80 + DA+ FG+VG P Sbjct: 60 DRFDTLRGYDALFFGAVGRPD 80 >UniRef50_A3JDN6 Isocitrate dehydrogenase n=5 Tax=Gammaproteobacteria RepID=A3JDN6_9ALTE Length = 582 Score = 77.6 bits (190), Expect = 6e-13, Method: Composition-based stats. Identities = 44/190 (23%), Positives = 78/190 (41%), Gaps = 22/190 (11%) Query: 180 FESARKRRHKVTSIDKANVLQSSILW----REIVNEIATEYPDV-ELAHMYIDNATMQLI 234 F A + +V K ++ ++ ++ E+A ++ M + +++I Sbjct: 373 FRDASSKHKEVYFGLKREYMEYDEVFSTVINDVRRELAADHTSPPAFMIMRPSSQLIKMI 432 Query: 235 KDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIA--- 291 DP + + NL GDI SD A + GS+ S ++ L+E G+A D+ Sbjct: 433 TDPPRSALYPAQNLDGDIFSDISAALGGSLATASSIIESKSSTMLFEAPHGTAHDLYLKY 492 Query: 292 ----GKNIA-NPIAQILSLALLLRYSLDAD------DAACAIERAINRALEEGIRTGDLA 340 GK+ NP A I +LA L + D + ++ A+ + +GI T DL Sbjct: 493 LESNGKDAHFNPSALIYALANALETLGRRERNEALLDYSARLKAALKDTVGDGIVTADLK 552 Query: 341 RGAAAVSTDE 350 +T E Sbjct: 553 D---KTTTPE 559 >UniRef50_Q7X199 Lfe195p1 (Fragment) n=4 Tax=Leptospirillum RepID=Q7X199_9BACT Length = 197 Score = 74.9 bits (183), Expect = 4e-12, Method: Composition-based stats. Identities = 27/79 (34%), Positives = 40/79 (50%), Gaps = 5/79 (6%) Query: 282 PAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEE-GIRTGDLA 340 GSAP AG NP A +LS ++L++ L+ +AA IE+ +++ L E T D Sbjct: 3 SVHGSAPKYAGMKKVNPSAVLLSGVMMLKW-LNEHEAATRIEKGVDKVLAEAKHLTYD-- 59 Query: 341 RGAAAVSTDEMGDIIARYV 359 STDE D I + + Sbjct: 60 -AGGTASTDEYADAIIKAM 77 >UniRef50_B9SFA3 NADP-specific isocitrate dehydrogenase, putative n=1 Tax=Ricinus communis RepID=B9SFA3_RICCO Length = 470 Score = 74.5 bits (182), Expect = 6e-12, Method: Composition-based stats. Identities = 64/405 (15%), Positives = 122/405 (30%), Gaps = 75/405 (18%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCE 66 I + GD E+ +++ + + ++D+G D + + E Sbjct: 87 IVEMDGD----EMTRVIWRMIKDKLIFPYLDLDIKYFDLGILNRDATDDKVTVESAEATL 142 Query: 67 QADAVLFGSVGGPKWEHLPPDQQPE--RGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 + + + + P + R +R P + P Sbjct: 143 KYNVAVKCATITPDETRVKEFGLKSMWRSPNGTIRNILNGTVFREPILCL-NIPRIVPGW 201 Query: 125 ADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAF---------DTEVYHRFE---- 171 I R G Y +G G+ + F + +VY Sbjct: 202 KKP------ICIGRHAFGDQYRATDTLIKGPGKLKMIFVPEDGNTPLELDVYDFKGPGVA 255 Query: 172 ---------IERIARIAFESARKRRHKVTSIDKANVLQS-SILWREIVNEIATE-----Y 216 I A + A ++ + K +L+ +++I E+ E + Sbjct: 256 LAMYNVDQSIRAFAESSMSLAFAKKWPLYLSTKNTILKKYDGRFKDIFQEVYEEKWKQKF 315 Query: 217 PD--VELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLN- 273 + + H ID+ +K + V C N GD+ SD + A+ Sbjct: 316 EEHSIWYEHRLIDDMVAYAVKSEGGY-VWACKNYDGDLSSD-------GKTLEAEAAHGT 367 Query: 274 -EQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDAD------DAACAIERAI 326 + F L++ ++ N IA I + L + D D +E + Sbjct: 368 VTRHFRLFQKGQETST--------NSIASIFAWTRGLEHRAKLDKNEGLLDFVHKLEGSC 419 Query: 327 NRALEEGIRTGDLA--RGAAAVS------TDEMGDIIARYVAEGV 363 +E G T DLA VS T+E D +A+ + + Sbjct: 420 IETVEAGKMTKDLAILIHGPKVSREFYLNTEEFIDAVAQNLESKL 464 >UniRef50_B8BX37 Predicted protein n=1 Tax=Thalassiosira pseudonana RepID=B8BX37_THAPS Length = 560 Score = 71.8 bits (175), Expect = 4e-11, Method: Composition-based stats. Identities = 69/412 (16%), Positives = 135/412 (32%), Gaps = 79/412 (19%) Query: 16 GPEVMTQALKVL--DAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCEQADAVLF 73 G E+ A ++L + F + + +D+ A D+ VE ++ A+ Sbjct: 89 GEEMTHYATQLLLNQWIEPYFDIS-SWETFDLSCKARDDSDDATLIDAVEAGKRIGAIFK 147 Query: 74 GSVGGPKWEHL--PPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRADIAANG 131 P + ++ +R+ + + R +G+E + + Sbjct: 148 EPTITPSAIQVQEMGLKKAWGSPNGAMRRGWNGITISRDTIHIEGIELGY--KNQVLFE- 204 Query: 132 FDILCVRELTGGIY-FGQPKGREG---------SGQYEKAFDTEVYHRF----------- 170 R GG Y G + EG G D Sbjct: 205 ------RHAVGGEYGAGWNEVGEGTLLTTYIPKDGGAPFVVDKRDLTDKHNVCVVYHNPY 258 Query: 171 -EIERIARIAFESARKRRHKVTSIDKANVLQ-SSILW---REIVNEIATE---------Y 216 + +A + F+ + + + K V + W + + ++ + Sbjct: 259 DNVRELAHLFFKRCLEHKVTPYIVTKKTVFKWQEGFWATMKRVFDDTYKDEFLKAGLLDR 318 Query: 217 PDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLN--E 274 EL H+ D ATMQLI+ + N GD+L+D+ A + S G + S + + Sbjct: 319 SGGELTHLISDAATMQLIRWTDGGFGMAAHNYDGDMLTDQIAQVHRSPGFITSNLVGVSD 378 Query: 275 QGFGL---YEPAGGSAPDIAGKNIA------NPIAQI--LSLALL----LRYSLDADD-A 318 G L +E + G+ D+ ++A NP+ + L A+ L Y +D Sbjct: 379 DGTTLIKEFEASHGTVTDLWNDHLAGKETSLNPLGLVEALLGAMCHAAQLEYDAKPNDVE 438 Query: 319 ACAIER-----------AINRALEEGIRTGDLARGAAAVSTDEMGDIIARYV 359 A + A++ G T D+ +T++ +A + Sbjct: 439 AKRMYEYVNNFTNTLRMALHNTFRYGQGTRDMCGPTG-FTTEDFIAKVAWRL 489 >UniRef50_B8KHT3 Isocitrate dehydrogenase, NADP-dependent n=3 Tax=unclassified Gammaproteobacteria (miscellaneous) RepID=B8KHT3_9GAMM Length = 580 Score = 69.9 bits (170), Expect = 1e-10, Method: Composition-based stats. Identities = 45/192 (23%), Positives = 76/192 (39%), Gaps = 19/192 (9%) Query: 169 RFEIERIARIAFESARKRRHKVTSIDKANVLQSSILWREIVNEIATE-----YPDVELAH 223 R I+ + F A + +V K + ++ I+ EI E P Sbjct: 362 RESIKDWVKQVFRDAALYKKEVYFGLKREFVNYDEVYSSIILEIRKELAALDTPPPSFMI 421 Query: 224 MYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPA 283 M ++I DP ++ + NL GDI SD A + GS+ S ++ G L+E Sbjct: 422 MRPSRQLSKMICDPPRWGLYPAQNLDGDIFSDISAALGGSLATASSVIKSKDGTLLFEAP 481 Query: 284 GGSAPDIAGKNIA--------NPIAQILSLALLLRYSLDAD------DAACAIERAINRA 329 G+A D+ + + N A I ++A L + + A A++ A+ Sbjct: 482 HGTAHDLYLRYLETDGKEANFNSSALIFAVANALEELARREDNAPLAEYAEALKAALIET 541 Query: 330 LEEGIRTGDLAR 341 + +G TGDL Sbjct: 542 VAQGTITGDLKG 553 >UniRef50_A8PW52 Probable isocitrate dehydrogenase, putative n=1 Tax=Brugia malayi RepID=A8PW52_BRUMA Length = 104 Score = 69.1 bits (168), Expect = 2e-10, Method: Composition-based stats. Identities = 20/79 (25%), Positives = 32/79 (40%), Gaps = 4/79 (5%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 + ++PGDGIGPE+ + K+ +A I DV D+ +P +E Sbjct: 27 RVTLIPGDGIGPEISSSVQKIFEAANA----PIEWDPVDVTPVKGDDGIFRIPSKCIELM 82 Query: 66 EQADAVLFGSVGGPKWEHL 84 L G + P W+ Sbjct: 83 RINKIGLKGPLATPNWQRT 101 >UniRef50_UPI0001AF5761 3-isopropylmalate dehydrogenase n=1 Tax=Pseudomonas syringae pv. oryzae str. 1_6 RepID=UPI0001AF5761 Length = 59 Score = 68.4 bits (166), Expect = 4e-10, Method: Composition-based stats. Identities = 28/54 (51%), Positives = 38/54 (70%), Gaps = 2/54 (3%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHG 54 MSK I +LPGDGIGPE+MT+A+KVL+ ++ + +H +GGAAID HG Sbjct: 8 MSK--QILILPGDGIGPEIMTEAVKVLELANEKYQLGFELTHDVIGGAAIDKHG 59 >UniRef50_B8P335 Predicted protein (Fragment) n=4 Tax=Dikarya RepID=B8P335_POSPM Length = 83 Score = 66.8 bits (162), Expect = 1e-09, Method: Composition-based stats. Identities = 20/75 (26%), Positives = 32/75 (42%), Gaps = 6/75 (8%) Query: 5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEG 64 Y + ++PGDGIG E+ ++ + V I Y+V G + G+ L VE Sbjct: 9 YTVTLIPGDGIGNEITDSVKEIFEYVNA----PIEWEQYNVSGMSSA--GEDLFKQAVES 62 Query: 65 CEQADAVLFGSVGGP 79 + L G + P Sbjct: 63 LRRNRVGLKGILFTP 77 >UniRef50_UPI0001910A87 3-isopropylmalate dehydrogenase n=1 Tax=Salmonella enterica subsp. enterica serovar Typhi str. E98-2068 RepID=UPI0001910A87 Length = 51 Score = 64.1 bits (155), Expect = 8e-09, Method: Composition-based stats. Identities = 45/51 (88%), Positives = 49/51 (96%) Query: 313 LDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYVAEGV 363 +DAD+AA AIE+AINRALEEG+RT DLARGAAAVSTDEMGDIIARYVAEGV Sbjct: 1 MDADEAATAIEQAINRALEEGVRTSDLARGAAAVSTDEMGDIIARYVAEGV 51 >UniRef50_B5G7Q5 Truncated isocitrate dehydrogenase family protein n=4 Tax=Streptomyces RepID=B5G7Q5_9ACTO Length = 411 Score = 63.0 bits (152), Expect = 2e-08, Method: Composition-based stats. Identities = 75/375 (20%), Positives = 120/375 (32%), Gaps = 48/375 (12%) Query: 5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEG 64 + + G G G EV +VL + R +T ++ P AT Sbjct: 31 PTVGLAVGRGTGEEVAAVFTRVLGHLATRHERPVTLVRSP---RVYHSYVSLRPLATEP- 86 Query: 65 CEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 G G P+ L + L R R A Q L Sbjct: 87 ---------GGAGVPEIRRLSAEDAAHYEEWLRARARAGTRVVFRTAINAQSLYLVRQRL 137 Query: 125 ADIAANGFD-----ILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIA 179 + + D +L VR+ G Y G G T + R E++ A Sbjct: 138 RAVKVDTLDADGARLLLVRDEAQGFYTGGNTHTPG-----HVSRTTEFSREITEQLLAYA 192 Query: 180 FESAR----KRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIK 235 AR + ++ K ++L V + A ++E+ D L+ Sbjct: 193 LRRAREEWPEGPARIVMAYKFHLL--DGALDAWVRDFAAR-ENIEVGVFQPDTVNRNLVA 249 Query: 236 D-PSQFDVLLCSNLFGDILSDECAMITGS----------MGMLPSASLNEQGFGLYEPAG 284 P VLL N + DI+ GS + + P+ Y+ Sbjct: 250 HPPEDRTVLLAGNEWADIMHLVLLDRYGSGRQEDHCTRNVHLDPAV----AELVEYQTVH 305 Query: 285 GSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAA 344 GSA D+ G+++ NP+A + + A + + A A E A+ R G+RT D Sbjct: 306 GSADDLEGRDLLNPVATLRAAAAIAERYVGCTGAEAATEAALARLAAAGVRTPD---QGG 362 Query: 345 AVSTDEMGDIIARYV 359 ST + D + Sbjct: 363 KHSTTGVVDAFIEEL 377 >UniRef50_UPI0001792E94 PREDICTED: similar to AGAP007786-PA n=1 Tax=Acyrthosiphon pisum RepID=UPI0001792E94 Length = 217 Score = 62.2 bits (150), Expect = 3e-08, Method: Composition-based stats. Identities = 20/66 (30%), Positives = 34/66 (51%), Gaps = 5/66 (7%) Query: 295 IANPIAQILSLALLLRYSLDADDAACAIERAINRALEEG-IRTGDLARGAAAVSTDEMGD 353 IANP A ++ + +LR+ ++ + +I AI L G +RT DL + ST E D Sbjct: 155 IANPTAMLMCASKMLRH-VNLQHYSESIRNAIREVLAAGKVRTRDL---GGSSSTHEFTD 210 Query: 354 IIARYV 359 + + + Sbjct: 211 AVIKAI 216 Score = 61.8 bits (149), Expect = 4e-08, Method: Composition-based stats. Identities = 21/101 (20%), Positives = 36/101 (35%), Gaps = 12/101 (11%) Query: 8 AVLPGDGIGPEVMTQALKVLDAVRNRFAMR-ITTSHYDVGGAAIDNHGQPLPPATVEGCE 66 ++PGDG+ PE+M VL A+ I S +A ++ Sbjct: 68 TLIPGDGVYPELMNSVQTVLKAIGAPIDFETILFSEVQHSSSAKV-------EDVIKSIN 120 Query: 67 QADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSN 107 + L G++ P + + + LRK L +N Sbjct: 121 RNRICLMGALMSPDVSY----SGELQNLHMKLRKGLDLIAN 157 >UniRef50_Q5D5H6 Isocitrate dehydrogenase, NAD-dependent (Fragment) n=2 Tax=Wolbachia RepID=Q5D5H6_9RICK Length = 212 Score = 57.6 bits (138), Expect = 7e-07, Method: Composition-based stats. Identities = 21/72 (29%), Positives = 30/72 (41%), Gaps = 4/72 (5%) Query: 294 NIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDL---ARGAAAVSTDE 350 NIANP + + +L Y + A I A + LE GI T DL R V T E Sbjct: 6 NIANPSGLLNAAVHMLIY-IGQVGTAKLIYDAWLKTLEGGIHTADLYKEKRSKQKVGTKE 64 Query: 351 MGDIIARYVAEG 362 + + + + Sbjct: 65 FAEAVIDNLGKK 76 >UniRef50_D0DDP2 3-isopropylmalate dehydrogenase n=1 Tax=Citreicella sp. SE45 RepID=D0DDP2_9RHOB Length = 81 Score = 55.6 bits (133), Expect = 3e-06, Method: Composition-based stats. Identities = 23/43 (53%), Positives = 27/43 (62%) Query: 279 LYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACA 321 ++EPA GSAPDIAG+NIANPIA I S A +L A Sbjct: 1 MFEPAHGSAPDIAGRNIANPIAAIWSGAQMLERHRGGHRAGHR 43 >UniRef50_B5E4Z3 3-isopropylmalate dehydrogenase, point mutation n=3 Tax=Streptococcus RepID=B5E4Z3_STRP4 Length = 51 Score = 54.5 bits (130), Expect = 5e-06, Method: Composition-based stats. Identities = 21/52 (40%), Positives = 27/52 (51%), Gaps = 2/52 (3%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDN 52 M+K I L GDGIGPE+M L+VL+A+ + GGA ID Sbjct: 1 MAK--KIVALAGDGIGPEIMEVGLEVLEALAEKTGFDYEIDRRPFGGADIDA 50 >UniRef50_A5B8K4 Putative uncharacterized protein n=2 Tax=Magnoliophyta RepID=A5B8K4_VITVI Length = 486 Score = 54.1 bits (129), Expect = 8e-06, Method: Composition-based stats. Identities = 67/435 (15%), Positives = 114/435 (26%), Gaps = 108/435 (24%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCE 66 I + GD E+ +++ + + ++D+G D + + E Sbjct: 67 IVEMDGD----EMARIMWRMIKDKLIFPYLDLDIRYFDLGILNRDATDDKVTVESAEATL 122 Query: 67 QADAVLFGSVGGPKWEHLPPDQQPE--RGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 + + + + P + R +R P L + P Sbjct: 123 KYNVAVKCATITPDEARVKEFGLKSMWRSPNGTIRNILNGTVFREPI-LCXNVPRIVPGW 181 Query: 125 ADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTE---------VYHRFE---- 171 I R G Y EG G+ + F E VY Sbjct: 182 KKP------ICIGRHAFGDQYRATDTVVEGPGKLKLVFAPENGDPPVELNVYDFKGPGIA 235 Query: 172 ---------IERIARIAFESARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELA 222 I A + A ++ + K +L+ +Y Sbjct: 236 LAMYNVDESIRAFAESSMSLAFAKKWPLYLSTKNTILK--------------KYDG-RYE 280 Query: 223 HMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAM----------------------- 259 H ID+ +K + V C N GD+ SD A Sbjct: 281 HRLIDDMVAYALKSDGGY-VWACKNYDGDVQSDLLAQGFLLHMRNERSDYPVXLHLVKSY 339 Query: 260 ----------ITG----SMGMLPSASLNEQGFGLYEPAGGSAPDI---AGKNI---ANPI 299 G S+ + ++ E A G+ K + N I Sbjct: 340 PILFVLSRIRFFGSYDFSIAISGKQLSSDGKTLEAEAAHGTVTRHFRQYQKGLETSTNSI 399 Query: 300 AQILSLALLLRYSLDADDAAC------AIERAINRALEEGIRTGDL--------ARGAAA 345 A I + L + D +E A +E G T DL A Sbjct: 400 ASIFAWTRGLEHRAKLDKNERLLDFVHKLEAACIETVESGNMTKDLAILIHGPKASXEFY 459 Query: 346 VSTDEMGDIIARYVA 360 ++T+E D +A + Sbjct: 460 LNTEEFIDTVAHNLE 474 >UniRef50_C6HDM5 Predicted protein n=1 Tax=Ajellomyces capsulatus H143 RepID=C6HDM5_AJECH Length = 168 Score = 54.1 bits (129), Expect = 9e-06, Method: Composition-based stats. Identities = 31/167 (18%), Positives = 53/167 (31%), Gaps = 34/167 (20%) Query: 69 DAVLFGSVGGPKWEHLPPDQQPERGALLPL---------------------RKHFKLFSN 107 DA L GSVG + + P + + R +L Sbjct: 6 DAYLLGSVGAARACMENTNINPYPSPIDAIGPSRPFFLIAILQTYLTISCSRVCLQL-VI 64 Query: 108 LRPAKLYQGLEAFCPLR--ADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTE 165 RP + Y P GF+ + V E G Y G S +E + Sbjct: 65 CRPREQYTNSNQQQPRSSLRGCQPRGFNWVIVPENPEGEYSGHSGRSHASKLWEMLITSG 124 Query: 166 VYHRFEIERIARIAFESARKRRHKVTSIDKANVLQSS-ILWREIVNE 211 +++IA++ R + K+N ++ ++W E+ E Sbjct: 125 ---------LSKIAYQLLRGPEKHIAIATKSNAQRNGLVIWNEVAAE 162 >UniRef50_P56471 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (Fragments) n=2 Tax=Laurasiatheria RepID=IDH3A_PIG Length = 90 Score = 51.8 bits (123), Expect = 4e-05, Method: Composition-based stats. Identities = 15/68 (22%), Positives = 27/68 (39%), Gaps = 4/68 (5%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRIT----TSHYDVGGAAIDNHGQPLPPAT 61 + ++PGDGIGPE+ +K+ DA + + Y +D + A Sbjct: 6 TVTLIPGDGIGPEISAAVMKIFDAAKAPIQANVRPCVSIEGYKFNEMYLDTVCLNIETAC 65 Query: 62 VEGCEQAD 69 + +D Sbjct: 66 FATIKCSD 73 >UniRef50_Q566P0 Zgc:113076 protein n=6 Tax=Deuterostomia RepID=Q566P0_DANRE Length = 66 Score = 49.5 bits (117), Expect = 2e-04, Method: Composition-based stats. Identities = 17/63 (26%), Positives = 27/63 (42%), Gaps = 5/63 (7%) Query: 301 QILSLALLLRYSLDADDAACAIERAINRAL-EEGIRTGDLARGAAAVSTDEMGDIIARYV 359 +L+ L+L + L D A I AI + E + T D+ +T E+ I R + Sbjct: 1 MLLASCLMLDH-LKLHDYANMIRSAILTTMNETRLHTVDIGGQG---TTSEVVQSIMRII 56 Query: 360 AEG 362 G Sbjct: 57 QSG 59 >UniRef50_Q11SB4 Putative uncharacterized protein ttuC n=1 Tax=Cytophaga hutchinsonii ATCC 33406 RepID=Q11SB4_CYTH3 Length = 286 Score = 49.1 bits (116), Expect = 2e-04, Method: Composition-based stats. Identities = 22/73 (30%), Positives = 32/73 (43%), Gaps = 6/73 (8%) Query: 279 LYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEE--GIRT 336 + P G APDI G IANP A +++ LL ++ A +E I A E T Sbjct: 206 ITMPMHGHAPDIVGMGIANPYALLMAFCRLLT-VAGYEELAQQVENQIESAFYENRDQTT 264 Query: 337 GDLARGAAAVSTD 349 D ++T+ Sbjct: 265 PD---QGGVLNTE 274 >UniRef50_A5LXH0 Putative uncharacterized protein n=1 Tax=Streptococcus pneumoniae SP9-BS68 RepID=A5LXH0_STRPN Length = 70 Score = 48.3 bits (114), Expect = 4e-04, Method: Composition-based stats. Identities = 16/42 (38%), Positives = 25/42 (59%), Gaps = 2/42 (4%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSH 42 M+K I L GDGIGPE+M L+VL+A+ + + + + Sbjct: 1 MAK--KIVALVGDGIGPEIMEAGLEVLEALAEKQVLTMRLTD 40 >UniRef50_Q4V533 IP13250p (Fragment) n=8 Tax=melanogaster subgroup RepID=Q4V533_DROME Length = 475 Score = 47.9 bits (113), Expect = 6e-04, Method: Composition-based stats. Identities = 21/99 (21%), Positives = 37/99 (37%), Gaps = 13/99 (13%) Query: 96 LPLRKHFKLFSNLRPAKLYQGLEAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGS 155 L + L+ + + G + P G DI + + GI F + + Sbjct: 132 LKICNDLDLYVFKTRTRSFPGFKCRFP--------GVDIQLIGQNNMGI-FNELEYSPVE 182 Query: 156 GQYEKAFDTEVYHRFEIERIARIAFE-SARKRRHKVTSI 193 G E V + ++ R AF+ +A+ R +VT I Sbjct: 183 GVVEA---LSVVSQKGNDKYLRYAFKAAAKAGRKRVTLI 218 >UniRef50_B5KE47 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Octadecabacter antarcticus 238 RepID=B5KE47_9RHOB Length = 343 Score = 47.6 bits (112), Expect = 8e-04, Method: Composition-based stats. Identities = 62/351 (17%), Positives = 116/351 (33%), Gaps = 54/351 (15%) Query: 1 MSKNYHIAVLPGD--GIGPEVMTQALK---VLDAVRNRFAMRITTSHYDVGGAAIDNHGQ 55 M+K IA++PGD GIGPE++ Q L V +A A + Sbjct: 6 MTKP-KIAIIPGDPSGIGPELIAQLLASDGVSEAADILLVGDTHIWEQGARQAGVRLQLD 64 Query: 56 PLPPATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQ 115 P+ A + + ++ + Q + AL L + L A + Sbjct: 65 PIAWANLAEFSGLRQLEMETIDVADVKVAEVTIQSGKSALRTLDQALDLAV----AGIVD 120 Query: 116 GLEAFCPLRADIAANGFDILCVRELTGGI------YFGQPKGREGSGQYEKAFDTEV--- 166 G+ +A + A G Y G + T V Sbjct: 121 GVLFGPFNKAALTAAGL-------NAEDEHRYMARYLGFKGYHSEVNVLDDLMTTRVTSH 173 Query: 167 ---------YHRFEIERIARIAFE-SARKRRHKVTSIDKA-NVLQSS--ILWREIVNEIA 213 + + +A + A+ + + A N RE ++ +A Sbjct: 174 IGLREVADNITADGVRKAIMMAHDTLAKAGKSRPHVAVAALNPHAGDNGKFGREEIDILA 233 Query: 214 TEYPDVELAHMYID----NATMQLIKDPSQFDVLLCSNLFGDILSDECAMITG---SMGM 266 + + HM++ + T+ L + D ++ ++ D + G + + Sbjct: 234 PVVAEYQGRHMHVSGPWPSDTVFLKAKAGEVDAVVT--MYHD-QGQIAIKLMGFDRGVTV 290 Query: 267 LPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADD 317 + + PA G+A DIAG+++AN A + LLLR ++ + Sbjct: 291 AGGLPI-----PVVTPAHGTAFDIAGQSVANVGATRNAFNLLLRLAVTHRE 336 >UniRef50_D1Z545 Whole genome shotgun sequence assembly, scaffold_4 n=1 Tax=Sordaria macrospora RepID=D1Z545_SORMA Length = 165 Score = 46.4 bits (109), Expect = 0.002, Method: Composition-based stats. Identities = 12/33 (36%), Positives = 21/33 (63%), Gaps = 1/33 (3%) Query: 189 KVTSIDKANVLQ-SSILWREIVNEIATEYPDVE 220 KVT I KAN+++ + L+ N +A ++P +E Sbjct: 79 KVTCIHKANIMKLADGLFHGTFNRLAKDFPQLE 111 >UniRef50_B8ARP0 Putative uncharacterized protein n=1 Tax=Oryza sativa Indica Group RepID=B8ARP0_ORYSI Length = 359 Score = 46.0 bits (108), Expect = 0.002, Method: Composition-based stats. Identities = 21/97 (21%), Positives = 36/97 (37%), Gaps = 9/97 (9%) Query: 172 IERIARIAFESARKRRHKVTSIDKANVLQS-SILWREIVNEI-------ATEYPDVELAH 223 I A + A ++ + K +L+ +++I E+ E + H Sbjct: 126 IRAFAESSMAMALSKKWPLYLSTKNTILKKYDGRFKDIFQEVYEEKWKEKFEENSIWYEH 185 Query: 224 MYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMI 260 ID+ +K + V C N GD+ SD A I Sbjct: 186 RLIDDMVAYAVKSEGGY-VWACKNYDGDVQSDFLAQI 221 >UniRef50_Q6UB50 Putative dehydrogenase (Fragment) n=1 Tax=Hyaloperonospora parasitica RepID=Q6UB50_9STRA Length = 55 Score = 46.0 bits (108), Expect = 0.002, Method: Composition-based stats. Identities = 19/51 (37%), Positives = 28/51 (54%), Gaps = 1/51 (1%) Query: 311 YSLDADDAACAIERAINRALEEGIRTGDLARGAAA-VSTDEMGDIIARYVA 360 YS + A IE+A+ + L +G+RTGDL + +A V T MG I + Sbjct: 1 YSFQMETEAQLIEKAVEQVLLDGMRTGDLTKDKSAVVGTKTMGAAIIAKMK 51 >UniRef50_Q1M832 Putative uncharacterized protein n=1 Tax=Rhizobium leguminosarum bv. viciae 3841 RepID=Q1M832_RHIL3 Length = 85 Score = 45.2 bits (106), Expect = 0.004, Method: Composition-based stats. Identities = 22/89 (24%), Positives = 34/89 (38%), Gaps = 9/89 (10%) Query: 273 NEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALE- 331 N G Y AP NI ++ I L + + + A AI A+ + L Sbjct: 5 NRHGLLFYAQQKRYAP-----NIERSVSPIRPQCLATCHHVGEGEKANAIRNAVEKVLNI 59 Query: 332 EGIRTGDLARGAAAVSTDEMGDIIARYVA 360 + +RTG L + +T E R +A Sbjct: 60 DNVRTGGL---GGSATTKEFTAATERRLA 85 >UniRef50_P56472 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (Fragments) n=1 Tax=Sus scrofa RepID=IDH3B_PIG Length = 103 Score = 44.5 bits (104), Expect = 0.007, Method: Composition-based stats. Identities = 16/81 (19%), Positives = 32/81 (39%), Gaps = 7/81 (8%) Query: 256 ECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRY---- 311 + ++G++ L + GL+ ++ KNIANP A +L+ ++L + Sbjct: 25 VGPELMAAVGVIECLKLGD---GLFLQCCEEVAELYPKNIANPTATLLASCMMLDHLKTS 81 Query: 312 SLDADDAACAIERAINRALEE 332 + A+ AL Sbjct: 82 DMGGYATCQDFTEAVIGALSH 102 >UniRef50_Q2VF40 Isocitrate dehydrogenase 3 gamma subunit (Fragment) n=1 Tax=Pan troglodytes RepID=Q2VF40_PANTR Length = 165 Score = 43.7 bits (102), Expect = 0.009, Method: Composition-based stats. Identities = 10/25 (40%), Positives = 15/25 (60%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLD 28 + + ++PGDGIGPE+M V Sbjct: 112 RHTVTMIPGDGIGPELMLHVKSVFR 136 >UniRef50_Q9SF26 Putative dehydrogenase n=1 Tax=Arabidopsis thaliana RepID=Q9SF26_ARATH Length = 91 Score = 43.7 bits (102), Expect = 0.010, Method: Composition-based stats. Identities = 11/40 (27%), Positives = 15/40 (37%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDV 45 + PGDGIGPE+ +V A +V Sbjct: 45 KATLFPGDGIGPEIAESVKQVFTAADVVIDWDEQFVGTEV 84 >UniRef50_Q0ZQ47 FrbB n=1 Tax=Streptomyces rubellomurinus RepID=Q0ZQ47_9ACTO Length = 352 Score = 43.3 bits (101), Expect = 0.013, Method: Composition-based stats. Identities = 54/339 (15%), Positives = 96/339 (28%), Gaps = 50/339 (14%) Query: 17 PE--VMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCEQADAVLFG 74 PE V+ AL++L++ RI G LPP G Sbjct: 18 PEASVLPAALELLESAGLTANWRIVAGQAPDGDGGRKPEAGLLPPFAEPGASAYGL---- 73 Query: 75 SVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRADIAANGFDI 134 + + RG L+ N+ + D++ G + Sbjct: 74 ARAARRAWGGTFSVIERRGPLVRS----DGTVNVLLFRY----------ELDMSDTGMEF 119 Query: 135 LCVRELTGGIYFGQPKGREGSGQYEK----AFDTEVYHRFEIERIARIAFESARKRR-HK 189 E G K G E A + + R A R+ Sbjct: 120 ----ESNSGEQLALVKTAAELGPREIPEQAALGIQAIAPDRVSEFVRTAVGMCRRLDVDD 175 Query: 190 VTSIDKAN-VLQSSILWREIVNEIATE---YPDVELAHMYIDNATMQLIKDPSQFDVLLC 245 + K N + + L+ E + + ID+ +L+++P + +L Sbjct: 176 LVVAHKGNSIKHTDGLFALTAAETLESLAGAAGIAWRSLIIDHMAAELVRNPLDYRAILT 235 Query: 246 SNLFGDILSDECAMITGS--MGMLPSAS-LNEQGFGLYEPAGGSAPDIAGKNIANP---- 298 + F D+L+ A + +G+ + FG SAPD A+P Sbjct: 236 HSSFADLLAAALAGQMTTDQLGVCTTYDPAGRPLFGHDPALDTSAPD------ADPERWR 289 Query: 299 ----IAQILSLALLLRYSLDADDAACAIERAINRALEEG 333 + + + A L + A +G Sbjct: 290 VRRLASTLAAGAALAEHLRLPPAGRALRRAAAELVRRDG 328 >UniRef50_A7IS87 LeuB (Fragment) n=1 Tax=Neisseria meningitidis RepID=A7IS87_NEIME Length = 44 Score = 42.5 bits (99), Expect = 0.024, Method: Composition-based stats. Identities = 17/47 (36%), Positives = 29/47 (61%), Gaps = 3/47 (6%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGG 47 M+K HIA+L GDGIG E++ + ++VLD + + + + +GG Sbjct: 1 MTK--HIAILRGDGIGSEIVAETVRVLDKLIAQ-GLDAGYEYAPLGG 44 >UniRef50_C0BPH4 3-isopropylmalate dehydrogenase n=1 Tax=Flavobacteria bacterium MS024-3C RepID=C0BPH4_9BACT Length = 105 Score = 42.2 bits (98), Expect = 0.028, Method: Composition-based stats. Identities = 30/86 (34%), Positives = 41/86 (47%), Gaps = 6/86 (6%) Query: 276 GFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEG-I 334 G L+EP S + K NPI I SLALLL + A AI+ A+N A E G Sbjct: 4 GINLFEPLEDSQSTL--KEKVNPIPLIYSLALLLS-RFGLQEEAGAIQMAVNSAGERGMY 60 Query: 335 RTGDLARGAAAVSTDEMGDIIARYVA 360 T D ++ D++GD +A + Sbjct: 61 TTLDTLP--KDINCDQLGDYLAAAII 84 >UniRef50_B7BAU1 Putative uncharacterized protein (Fragment) n=1 Tax=Parabacteroides johnsonii DSM 18315 RepID=B7BAU1_9PORP Length = 52 Score = 41.0 bits (95), Expect = 0.063, Method: Composition-based stats. Identities = 15/46 (32%), Positives = 21/46 (45%), Gaps = 3/46 (6%) Query: 313 LDADDAACAIERAINRALEEGIRTGDLAR---GAAAVSTDEMGDII 355 + ++A I A+ A EG T DLAR + T E G+ I Sbjct: 3 MGWNEAGRLITAALEHAFSEGKATRDLARFMPNGQPLGTKEFGEYI 48 Searching..................................................done Results from round 3 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_Q4QLS3 3-isopropylmalate dehydrogenase n=43 Tax=Bacteri... 438 e-121 UniRef50_Q47WG3 3-isopropylmalate dehydrogenase n=20 Tax=Bacteri... 423 e-117 UniRef50_Q9WZ26 3-isopropylmalate dehydrogenase n=47 Tax=Bacteri... 422 e-117 UniRef50_D1HRU7 3-isopropylmalate dehydrogenase (Fragment) n=2 T... 417 e-115 UniRef50_Q493R1 3-isopropylmalate dehydrogenase n=224 Tax=Bacter... 412 e-113 UniRef50_Q9FMT1 3-isopropylmalate dehydrogenase 3, chloroplastic... 403 e-111 UniRef50_C9KJM9 3-isopropylmalate dehydrogenase n=1 Tax=Mitsuoke... 395 e-108 UniRef50_Q6GF15 3-isopropylmalate dehydrogenase n=94 Tax=Bacilli... 390 e-107 UniRef50_Q5SIY4 3-isopropylmalate dehydrogenase n=53 Tax=cellula... 388 e-106 UniRef50_Q55BI2 Isocitrate dehydrogenase [NAD] regulatory subuni... 384 e-105 UniRef50_Q1IJA8 Isocitrate dehydrogenase (NAD+) n=19 Tax=Bacteri... 381 e-104 UniRef50_Q4FP17 3-isopropylmalate dehydrogenase n=11 Tax=cellula... 380 e-104 UniRef50_Q81G11 3-isopropylmalate dehydrogenase n=105 Tax=Bacter... 380 e-104 UniRef50_O29627 3-isopropylmalate dehydrogenase n=91 Tax=cellula... 378 e-103 UniRef50_C4Q3D3 Unc-13 (Munc13), putative n=38 Tax=cellular orga... 378 e-103 UniRef50_Q5HMF8 3-isopropylmalate dehydrogenase n=9 Tax=Bacilli ... 377 e-103 UniRef50_Q2JUI3 Isopropylmalate/isohomocitrate dehydrogenase fam... 377 e-103 UniRef50_Q2YL58 3-isopropylmalate dehydrogenase n=285 Tax=cellul... 377 e-103 UniRef50_B1I496 3-isopropylmalate dehydrogenase n=4 Tax=Bacteria... 376 e-103 UniRef50_Q46NL2 Tartrate dehydrogenase n=12 Tax=Bacteria RepID=Q... 375 e-102 UniRef50_A3P147 Tartrate dehydrogenase n=59 Tax=Bacteria RepID=A... 375 e-102 UniRef50_P50213 Isocitrate dehydrogenase [NAD] subunit alpha, mi... 374 e-102 UniRef50_Q2J3B4 3-isopropylmalate dehydrogenase n=132 Tax=Bacter... 371 e-101 UniRef50_Q46FW0 3-isopropylmalate dehydrogenase n=11 Tax=Euryarc... 370 e-101 UniRef50_D0J9Z6 3-isopropylmalate dehydrogenase n=7 Tax=Bacteroi... 370 e-101 UniRef50_D2EFL9 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 370 e-101 UniRef50_O27441 3-isopropylmalate dehydrogenase n=30 Tax=Archaea... 369 e-101 UniRef50_A4IK21 Tartrate dehydrogenase n=7 Tax=Bacillaceae RepID... 368 e-100 UniRef50_Q2RV53 3-isopropylmalate dehydrogenase n=103 Tax=Bacter... 368 e-100 UniRef50_B8N3I6 Tartrate dehydrogenase, putative n=3 Tax=Trichoc... 367 e-100 UniRef50_Q2VZV2 3-isopropylmalate dehydrogenase n=35 Tax=Bacteri... 367 e-100 UniRef50_B3TCK6 Putative isocitrate/isopropylmalate dehydrogenas... 367 e-100 UniRef50_Q51945 Tartrate dehydrogenase/decarboxylase n=249 Tax=c... 366 e-100 UniRef50_Q58991 Homoisocitrate dehydrogenase n=21 Tax=Euryarchae... 365 1e-99 UniRef50_A5CDH3 Isocitrate dehydrogenase, NADP-dependent n=7 Tax... 365 2e-99 UniRef50_Q2K2V0 3-isopropylmalate dehydrogenase n=11 Tax=Alphapr... 364 3e-99 UniRef50_Q5SIJ1 Homoisocitrate dehydrogenase n=13 Tax=cellular o... 363 4e-99 UniRef50_P70787 Probable tartrate dehydrogenase/decarboxylase tt... 363 6e-99 UniRef50_P42958 Probable tartrate dehydrogenase/decarboxylase n=... 363 6e-99 UniRef50_Q6W109 Tartrate dehydrogenase n=13 Tax=Bacteria RepID=Q... 361 2e-98 UniRef50_Q5LAB4 3-isopropylmalate dehydrogenase n=58 Tax=Bacteri... 361 3e-98 UniRef50_B9KYU3 Isocitrate dehydrogenase (NADP) n=3 Tax=Bacteria... 359 8e-98 UniRef50_A9IDG2 Tartrate dehydrogenase n=5 Tax=cellular organism... 359 8e-98 UniRef50_UPI000150AB37 dehydrogenase, isocitrate/isopropylmalate... 358 2e-97 UniRef50_Q0D0R7 Isocitrate dehydrogenase subunit 2, mitochondria... 358 2e-97 UniRef50_P33197 Isocitrate dehydrogenase [NADP] n=10 Tax=Bacteri... 357 3e-97 UniRef50_B1MJY2 Tartrate dehydrogenase n=5 Tax=Bacteria RepID=B1... 354 2e-96 UniRef50_C1XGT6 Homoisocitrate dehydrogenase n=1 Tax=Meiothermus... 353 4e-96 UniRef50_Q1ARE1 3-isopropylmalate dehydrogenase n=2 Tax=Bacteria... 353 5e-96 UniRef50_C3MI61 3-isopropylmalate dehydrogenase n=13 Tax=Proteob... 353 5e-96 UniRef50_Q2JYV7 Probable tartrate dehydrogenase protein n=7 Tax=... 351 3e-95 UniRef50_P04173 3-isopropylmalate dehydrogenase n=61 Tax=Fungi/M... 349 1e-94 UniRef50_UPI0001C310FF Tartrate decarboxylase n=1 Tax=Conexibact... 349 1e-94 UniRef50_UPI0001B4F4BD putative isocitrate/isopropylmalate dehyd... 347 4e-94 UniRef50_A5US63 Homoisocitrate dehydrogenase n=6 Tax=Chloroflexi... 346 8e-94 UniRef50_Q0W5L4 3-isopropylmalate dehydrogenase n=14 Tax=root Re... 345 2e-93 UniRef50_D0DDG4 3-isopropylmalate dehydrogenase n=1 Tax=Citreice... 343 4e-93 UniRef50_P40495 Homoisocitrate dehydrogenase, mitochondrial n=66... 343 9e-93 UniRef50_Q1RJU4 Isocitrate dehydrogenase [NADP] n=62 Tax=cellula... 342 1e-92 UniRef50_P34738 3-isopropylmalate dehydrogenase n=8 Tax=cellular... 341 2e-92 UniRef50_A9QPI0 Isocitrate/isopropylmalate dehydrogenase n=3 Tax... 341 3e-92 UniRef50_A1SWV5 3-isopropylmalate dehydrogenase n=1 Tax=Psychrom... 341 3e-92 UniRef50_Q12545 3-isopropylmalate dehydrogenase n=54 Tax=cellula... 341 3e-92 UniRef50_B0ER68 Tartrate dehydrogenase, putative n=2 Tax=Entamoe... 340 5e-92 UniRef50_P28241 Isocitrate dehydrogenase [NAD] subunit 2, mitoch... 339 8e-92 UniRef50_C1F3J9 Isocitrate dehydrogenase n=1 Tax=Acidobacterium ... 338 2e-91 UniRef50_D0RN50 Threo-isocitrate dehydrogenase [NAD] n=1 Tax=alp... 338 2e-91 UniRef50_A6WAX5 3-isopropylmalate dehydrogenase n=20 Tax=Bacteri... 337 4e-91 UniRef50_O81796 Isocitrate dehydrogenase [NAD] regulatory subuni... 336 7e-91 UniRef50_A5UMS5 3-isopropylmalate dehydrogenase, LeuB n=8 Tax=Eu... 334 2e-90 UniRef50_P41564 Isocitrate dehydrogenase [NAD] subunit gamma, mi... 334 3e-90 UniRef50_Q0BQF4 Isocitrate dehydrogenase (NADP) n=14 Tax=Proteob... 333 5e-90 UniRef50_P51553 Isocitrate dehydrogenase [NAD] subunit gamma, mi... 333 6e-90 UniRef50_A8TPC9 3-isopropylmalate dehydrogenase n=3 Tax=Alphapro... 333 8e-90 UniRef50_D0LNY3 3-isopropylmalate dehydrogenase n=1 Tax=Haliangi... 333 9e-90 UniRef50_O59930 3-isopropylmalate dehydrogenase n=12 Tax=cellula... 332 1e-89 UniRef50_D2VFR4 Homo-isocitrate dehydrogenase n=1 Tax=Naegleria ... 331 3e-89 UniRef50_Q47SB4 3-isopropylmalate dehydrogenase n=15 Tax=cellula... 330 4e-89 UniRef50_B1L3C1 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 329 1e-88 UniRef50_Q7UTP0 3-isopropylmalate dehydrogenase n=1 Tax=Rhodopir... 328 2e-88 UniRef50_B0RIP4 3-isopropylmalate dehydrogenase n=140 Tax=Bacter... 328 2e-88 UniRef50_UPI0001AF2578 isocitrate dehydrogenase [NADP] (oxalosuc... 327 4e-88 UniRef50_C6V444 Isocitrate dehydrogenase n=2 Tax=Neorickettsia R... 327 4e-88 UniRef50_A7SJV9 Predicted protein n=1 Tax=Nematostella vectensis... 327 5e-88 UniRef50_C4QCG1 Isocitrate dehydrogenase [NAD] subunit gamma, mi... 326 1e-87 UniRef50_D2RVT1 Isocitrate dehydrogenase, NADP-dependent n=1 Tax... 325 1e-87 UniRef50_C7RJH9 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 325 1e-87 UniRef50_O13696 Isocitrate dehydrogenase [NAD] subunit 1, mitoch... 323 5e-87 UniRef50_B3RY01 Putative uncharacterized protein n=1 Tax=Trichop... 323 6e-87 UniRef50_A5FXZ9 3-isopropylmalate dehydrogenase n=2 Tax=Alphapro... 323 7e-87 UniRef50_B7PN53 Isocitrate dehydrogenase, putative (Fragment) n=... 321 2e-86 UniRef50_Q5P9Q1 Isocitrate dehydrogenase n=13 Tax=Rickettsiales ... 319 7e-86 UniRef50_Q05FQ8 3-isopropylmalate dehydrogenase n=1 Tax=Candidat... 319 1e-85 UniRef50_Q1IMD5 3-isopropylmalate dehydrogenase n=3 Tax=cellular... 319 1e-85 UniRef50_D1B742 3-isopropylmalate dehydrogenase n=2 Tax=Synergis... 319 1e-85 UniRef50_Q8XSY8 Probable 3-isopropylmalate dehydrogenase oxidore... 319 1e-85 UniRef50_Q0ZQ44 FrbE n=1 Tax=Streptomyces rubellomurinus RepID=Q... 318 2e-85 UniRef50_C7P3E9 Isocitrate dehydrogenase, NADP-dependent n=5 Tax... 318 3e-85 UniRef50_C7MQT6 Isocitrate/isopropylmalate dehydrogenase n=1 Tax... 318 3e-85 UniRef50_C0WN79 Isocitrate dehydrogenase [NADP] n=4 Tax=Lactobac... 318 3e-85 UniRef50_B8NJA6 3-isopropymalate dehydrogenase, putative n=3 Tax... 316 6e-85 UniRef50_Q6GG12 Isocitrate dehydrogenase [NADP] n=90 Tax=root Re... 316 6e-85 UniRef50_B8M3W0 3-isopropylmalate dehydrogenase n=6 Tax=Leotiomy... 316 8e-85 UniRef50_A9UQS3 Predicted protein n=1 Tax=Monosiga brevicollis R... 316 1e-84 UniRef50_Q5JFV8 Homoisocitrate dehydrogenase n=4 Tax=Thermococca... 314 2e-84 UniRef50_Q4ZRW7 3-isopropylmalate dehydrogenase n=13 Tax=Proteob... 314 3e-84 UniRef50_P28834 Isocitrate dehydrogenase [NAD] subunit 1, mitoch... 313 5e-84 UniRef50_A1WHK9 3-isopropylmalate dehydrogenase n=5 Tax=Proteoba... 313 5e-84 UniRef50_A9FME3 3-isopropylmalate dehydrogenase n=7 Tax=Proteoba... 313 7e-84 UniRef50_P96318 Isocitrate dehydrogenase [NADP] n=5 Tax=cellular... 312 1e-83 UniRef50_Q48806 Protein dlpA n=5 Tax=Legionella RepID=DLPA_LEGPH 311 2e-83 UniRef50_C5EHC0 3-isopropylmalate dehydrogenase n=1 Tax=Clostrid... 311 2e-83 UniRef50_Q9U6V3 Isocitrate dehydrogenase gamma subunit n=4 Tax=B... 311 3e-83 UniRef50_B1L5I7 Isocitrate dehydrogenase (NAD(+)) n=1 Tax=Candid... 311 3e-83 UniRef50_Q0X0C1 Putative dehydrogenase n=2 Tax=Streptomyces RepI... 310 5e-83 UniRef50_O67480 Isocitrate dehydrogenase [NADP] n=5 Tax=Aquifica... 309 1e-82 UniRef50_B7UV18 Isocitrate dehydrogenase [NADP] n=9 Tax=Gammapro... 308 2e-82 UniRef50_B2J8P1 3-isopropylmalate dehydrogenase n=3 Tax=Cyanobac... 308 2e-82 UniRef50_UPI00019260EC PREDICTED: similar to predicted protein i... 308 3e-82 UniRef50_O43837 Isocitrate dehydrogenase [NAD] subunit beta, mit... 307 4e-82 UniRef50_A4WLX6 Isocitrate dehydrogenase (NADP) n=22 Tax=Archaea... 307 4e-82 UniRef50_A0D2B8 Chromosome undetermined scaffold_35, whole genom... 306 6e-82 UniRef50_D1B6F8 3-isopropylmalate dehydrogenase n=1 Tax=Thermana... 302 1e-80 UniRef50_A6G3V7 Probable 3-isopropylmalate dehydrogenase n=2 Tax... 302 1e-80 UniRef50_D2SEJ6 3-isopropylmalate dehydrogenase n=3 Tax=Actinomy... 301 2e-80 UniRef50_Q4P2R4 3-isopropylmalate dehydrogenase n=1 Tax=Ustilago... 301 3e-80 UniRef50_A0P1S6 3-isopropylmalate dehydrogenase n=3 Tax=Rhodobac... 299 7e-80 UniRef50_P41560 Isocitrate dehydrogenase [NADP] 1 n=78 Tax=cellu... 298 2e-79 UniRef50_Q9ZN36 Isocitrate dehydrogenase [NADP] n=932 Tax=root R... 297 5e-79 UniRef50_A9A2N6 Isocitrate dehydrogenase (NAD(+)) n=11 Tax=Archa... 294 4e-78 UniRef50_Q3IKZ8 Isocitrate dehydrogenase, specific for NADP+ n=3... 291 2e-77 UniRef50_Q18GT1 3-isopropylmalate dehydrogenase n=8 Tax=Halobact... 286 8e-76 UniRef50_D2Y061 Isocitrate dehydrogenase n=1 Tax=Bombyx mori Rep... 285 2e-75 UniRef50_Q0A635 Isocitrate/isopropylmalate dehydrogenase n=1 Tax... 281 4e-74 UniRef50_A1WV93 3-isopropylmalate dehydrogenase n=8 Tax=Gammapro... 281 4e-74 UniRef50_D2VM48 Isocitrate dehydrogenase n=1 Tax=Naegleria grube... 277 4e-73 UniRef50_O15384 NAD (H)-specific isocitrate dehydrogenase gamma ... 275 2e-72 UniRef50_A9KQX3 Isocitrate dehydrogenase (NAD(+)) n=5 Tax=cellul... 274 4e-72 UniRef50_UPI000186E03D isocitrate dehydrogenase, putative n=1 Ta... 272 1e-71 UniRef50_UPI000038E0FC 3-isopropylmalate dehydrogenase n=1 Tax=F... 271 3e-71 UniRef50_UPI000185C11E 3-isopropylmalate dehydrogenase n=1 Tax=C... 271 3e-71 UniRef50_UPI00016C59BF Isocitrate dehydrogenase (NAD+) n=1 Tax=G... 267 3e-70 UniRef50_C9SEZ4 Homoisocitrate dehydrogenase n=1 Tax=Verticilliu... 263 6e-69 UniRef50_D2RML7 Isocitrate/isopropylmalate dehydrogenase n=6 Tax... 261 4e-68 UniRef50_Q2HAA2 Putative uncharacterized protein n=2 Tax=Chaetom... 261 4e-68 UniRef50_Q6L0K7 3-isopropylmalate dehydrogenase n=1 Tax=Picrophi... 259 2e-67 UniRef50_C0W9Q2 Isocitrate dehydrogenase n=2 Tax=Clostridiales R... 258 3e-67 UniRef50_A9B3D4 Isocitrate/isopropylmalate dehydrogenase n=4 Tax... 257 5e-67 UniRef50_A6GJ83 Isocitrate dehydrogenase n=1 Tax=Plesiocystis pa... 257 5e-67 UniRef50_B5RJP2 FI08066p (Fragment) n=18 Tax=Sophophora RepID=B5... 256 8e-67 UniRef50_B8FQF2 Isocitrate/isopropylmalate dehydrogenase n=2 Tax... 254 5e-66 UniRef50_B7KHW3 Isocitrate/isopropylmalate dehydrogenase n=11 Ta... 245 2e-63 UniRef50_UPI00017936A6 PREDICTED: similar to isocitrate dehydrog... 239 1e-61 UniRef50_D2SD16 Malate/L-lactate dehydrogenase n=1 Tax=Geodermat... 235 3e-60 UniRef50_B4MP27 GK19462 n=1 Tax=Drosophila willistoni RepID=B4MP... 234 3e-60 UniRef50_UPI0001C31665 isocitrate/isopropylmalate dehydrogenase ... 232 1e-59 UniRef50_Q961P4 GH13226p n=4 Tax=Drosophila RepID=Q961P4_DROME 230 5e-59 UniRef50_B0BZF3 Isocitrate dehydrogenase NAD-dependent n=1 Tax=A... 230 6e-59 UniRef50_C5GTE7 Tartrate dehydrogenase n=2 Tax=Ajellomyces derma... 229 1e-58 UniRef50_C7YX79 Putative uncharacterized protein (Fragment) n=1 ... 226 7e-58 UniRef50_B1VH60 Putative dehydrogenase n=1 Tax=Corynebacterium u... 223 7e-57 UniRef50_A4FEJ6 3-isopropylmalate dehydrogenase n=1 Tax=Saccharo... 220 8e-56 UniRef50_O75874 Isocitrate dehydrogenase [NADP] cytoplasmic n=36... 215 3e-54 UniRef50_UPI00003C8595 isocitrate dehydrogenase n=1 Tax=Ferropla... 215 3e-54 UniRef50_P50217 Isocitrate dehydrogenase [NADP] n=49 Tax=cellula... 213 7e-54 UniRef50_P48735 Isocitrate dehydrogenase [NADP], mitochondrial n... 211 3e-53 UniRef50_B6KL81 Isocitrate dehydrogenase, putative n=6 Tax=cellu... 203 7e-51 UniRef50_Q0CXI1 Isocitrate dehydrogenase, mitochondrial n=2 Tax=... 202 2e-50 UniRef50_Q0V3G8 Putative uncharacterized protein n=1 Tax=Phaeosp... 199 1e-49 UniRef50_Q9LQK9 Putative isocitrate dehydrogenase [NAD] subunit-... 196 1e-48 UniRef50_B4PZH5 GE17383 n=3 Tax=Drosophila RepID=B4PZH5_DROYA 192 1e-47 UniRef50_D0WIJ5 Isocitrate dehydrogenase, NADP-dependent n=2 Tax... 187 7e-46 UniRef50_B9SFA3 NADP-specific isocitrate dehydrogenase, putative... 182 2e-44 UniRef50_C5FHL7 Isocitrate dehydrogenase family protein n=1 Tax=... 175 3e-42 UniRef50_UPI0001C163C2 Isocitrate dehydrogenase NADP-dependent, ... 174 3e-42 UniRef50_A1D5P0 Isocitrate dehydrogenase family protein n=4 Tax=... 169 1e-40 UniRef50_P80046 Isocitrate dehydrogenase [NADP] n=54 Tax=cellula... 168 2e-40 UniRef50_A8E541 Idh3a protein n=4 Tax=Euteleostomi RepID=A8E541_... 167 4e-40 UniRef50_A5B8K4 Putative uncharacterized protein n=2 Tax=Magnoli... 165 2e-39 UniRef50_A2Q9Q7 Contig An01c0300, complete genome n=6 Tax=Tricho... 164 4e-39 UniRef50_A4SBK5 Predicted protein n=6 Tax=Eukaryota RepID=A4SBK5... 161 3e-38 UniRef50_B5DZV4 GA24694 n=6 Tax=Drosophila RepID=B5DZV4_DROPS 159 2e-37 UniRef50_B3MF82 GF11274 n=1 Tax=Drosophila ananassae RepID=B3MF8... 156 1e-36 UniRef50_B8BX37 Predicted protein n=1 Tax=Thalassiosira pseudona... 155 2e-36 UniRef50_C7YNU4 Putative uncharacterized protein n=1 Tax=Nectria... 154 4e-36 UniRef50_Q6L1Z1 Isocitrate dehydrogenase [NADP] n=1 Tax=Picrophi... 154 4e-36 UniRef50_UPI00017440F3 Isocitrate dehydrogenase (NAD(+)) n=1 Tax... 146 1e-33 UniRef50_A7T3D9 Predicted protein n=2 Tax=cellular organisms Rep... 146 1e-33 UniRef50_Q03UU7 3-isopropylmalate dehydrogenase n=4 Tax=Leuconos... 142 2e-32 UniRef50_Q7XZ87 Isocitrate dehydrogenase (Fragment) n=1 Tax=Grif... 138 3e-31 UniRef50_B5G7Q5 Truncated isocitrate dehydrogenase family protei... 132 2e-29 UniRef50_A5BNI3 Putative uncharacterized protein n=1 Tax=Vitis v... 123 9e-27 UniRef50_A3JDN6 Isocitrate dehydrogenase n=5 Tax=Gammaproteobact... 116 9e-25 UniRef50_Q8T494 AT08722p n=1 Tax=Drosophila melanogaster RepID=Q... 116 2e-24 UniRef50_B8KHT3 Isocitrate dehydrogenase, NADP-dependent n=3 Tax... 115 2e-24 UniRef50_B5KE47 4-hydroxythreonine-4-phosphate dehydrogenase n=1... 105 3e-21 UniRef50_B6QRT7 3-isopropylmalate dehydrogenase, putative n=1 Ta... 105 4e-21 UniRef50_B1XUL5 Tartrate dehydrogenase n=1 Tax=Polynucleobacter ... 103 1e-20 UniRef50_C7GAF7 3-isopropylmalate dehydrogenase (Fragment) n=1 T... 101 4e-20 UniRef50_Q567A6 Isocitrate dehydrogenase 3 (NAD+) gamma n=1 Tax=... 93 2e-17 UniRef50_Q8KH40 LeuB (Fragment) n=3 Tax=Buchnera aphidicola RepI... 92 3e-17 UniRef50_Q8N9Z6 cDNA FLJ36019 fis, clone TESTI2016421, highly si... 90 1e-16 UniRef50_C1GSN2 3-isopropylmalate dehydrogenase n=4 Tax=Onygenal... 86 2e-15 UniRef50_Q84AT8 LeuB (Fragment) n=1 Tax=Buchnera aphidicola RepI... 84 7e-15 UniRef50_Q1G324 Putative uncharacterized protein n=1 Tax=Arabido... 83 2e-14 UniRef50_Q7X199 Lfe195p1 (Fragment) n=4 Tax=Leptospirillum RepID... 82 4e-14 UniRef50_B6QD56 Putative uncharacterized protein n=1 Tax=Penicil... 79 2e-13 UniRef50_A3RRN5 Tartrate dehydrogenase n=3 Tax=Ralstonia solanac... 75 3e-12 UniRef50_A8PW52 Probable isocitrate dehydrogenase, putative n=1 ... 75 4e-12 UniRef50_UPI0001792E94 PREDICTED: similar to AGAP007786-PA n=1 T... 70 2e-10 UniRef50_B8P335 Predicted protein (Fragment) n=4 Tax=Dikarya Rep... 69 2e-10 UniRef50_Q5D5H6 Isocitrate dehydrogenase, NAD-dependent (Fragmen... 67 8e-10 UniRef50_C6HDM5 Predicted protein n=1 Tax=Ajellomyces capsulatus... 67 9e-10 UniRef50_UPI0001AF5761 3-isopropylmalate dehydrogenase n=1 Tax=P... 64 7e-09 UniRef50_D0DDP2 3-isopropylmalate dehydrogenase n=1 Tax=Citreice... 60 1e-07 UniRef50_Q11SB4 Putative uncharacterized protein ttuC n=1 Tax=Cy... 59 2e-07 UniRef50_Q4V533 IP13250p (Fragment) n=8 Tax=melanogaster subgrou... 57 8e-07 UniRef50_B5E4Z3 3-isopropylmalate dehydrogenase, point mutation ... 55 3e-06 UniRef50_UPI0001910A87 3-isopropylmalate dehydrogenase n=1 Tax=S... 55 6e-06 UniRef50_Q566P0 Zgc:113076 protein n=6 Tax=Deuterostomia RepID=Q... 54 8e-06 UniRef50_P56471 Isocitrate dehydrogenase [NAD] subunit alpha, mi... 53 1e-05 UniRef50_A5LXH0 Putative uncharacterized protein n=1 Tax=Strepto... 49 3e-04 Sequences not found previously or not previously below threshold: UniRef50_B8ARP0 Putative uncharacterized protein n=1 Tax=Oryza s... 89 2e-16 UniRef50_B5X9F9 Isocitrate dehydrogenase, mitochondrial n=6 Tax=... 64 7e-09 UniRef50_P56472 Isocitrate dehydrogenase [NAD] subunit beta, mit... 50 2e-04 UniRef50_Q0ZQ47 FrbB n=1 Tax=Streptomyces rubellomurinus RepID=Q... 48 4e-04 UniRef50_Q9SF26 Putative dehydrogenase n=1 Tax=Arabidopsis thali... 47 0.001 UniRef50_D2H627 Putative uncharacterized protein n=1 Tax=Ailurop... 47 0.001 UniRef50_Q9H302 NADP+-specific isocitrate dehydrogenase (Fragmen... 46 0.001 UniRef50_Q4VCC2 Isocitrate dehydrogenase (Fragment) n=1 Tax=Salt... 46 0.002 UniRef50_Q6UB50 Putative dehydrogenase (Fragment) n=1 Tax=Hyalop... 45 0.003 UniRef50_D1J805 Signal recognition particle protein (Fifty fourh... 45 0.004 UniRef50_Q2VF40 Isocitrate dehydrogenase 3 gamma subunit (Fragme... 45 0.005 UniRef50_C5K691 Nadp-specific isocitrate dehydrogenase, putative... 45 0.005 UniRef50_C0BPH4 3-isopropylmalate dehydrogenase n=1 Tax=Flavobac... 45 0.005 UniRef50_B7BAU1 Putative uncharacterized protein (Fragment) n=1 ... 45 0.005 UniRef50_Q1M832 Putative uncharacterized protein n=1 Tax=Rhizobi... 43 0.013 UniRef50_D1Z545 Whole genome shotgun sequence assembly, scaffold... 42 0.032 UniRef50_A7IS87 LeuB (Fragment) n=1 Tax=Neisseria meningitidis R... 41 0.068 >UniRef50_Q4QLS3 3-isopropylmalate dehydrogenase n=43 Tax=Bacteria RepID=LEU3_HAEI8 Length = 358 Score = 438 bits (1126), Expect = e-121, Method: Composition-based stats. Identities = 254/357 (71%), Positives = 299/357 (83%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATV 62 ++Y++AVL GDGIGPEVM +A+KVL+ V+ +F ++ + + VGGAAID+ G PLP T+ Sbjct: 2 QSYNVAVLAGDGIGPEVMAEAMKVLNKVQEKFGFKLNFNEFFVGGAAIDHCGYPLPAETL 61 Query: 63 EGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 +GC++ADA+LFGSVGGPKW +LPPDQQPERGALLPLRKHFKLF NLRPA LY+GLE FCP Sbjct: 62 KGCDEADAILFGSVGGPKWTNLPPDQQPERGALLPLRKHFKLFCNLRPATLYKGLEKFCP 121 Query: 123 LRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFES 182 LRADIAA GFD++ VRELTGGIYFGQPKGREG G KAFDTEVY+++EIERIAR AFE+ Sbjct: 122 LRADIAAKGFDMVVVRELTGGIYFGQPKGREGEGSQTKAFDTEVYYKYEIERIARAAFEA 181 Query: 183 ARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDV 242 A KR KVTS+DKANVLQSSILWRE V E+A +YP+V L H+YIDNATMQLIK P FDV Sbjct: 182 AMKRNKKVTSVDKANVLQSSILWRETVTEMAKDYPEVTLEHIYIDNATMQLIKAPESFDV 241 Query: 243 LLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQI 302 LLCSN+FGDI+SDE AMITGSMGMLPSASLNE GFGLYEPAGGSAPDIAGK IANPIAQI Sbjct: 242 LLCSNIFGDIISDEAAMITGSMGMLPSASLNEAGFGLYEPAGGSAPDIAGKGIANPIAQI 301 Query: 303 LSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYV 359 LS A++LRYS + ++AA AIE A+ + L G RT DLA + VST EMG +I + + Sbjct: 302 LSAAMMLRYSFNLNEAADAIESAVQKVLASGHRTADLADDSTPVSTAEMGTLITQAI 358 >UniRef50_Q47WG3 3-isopropylmalate dehydrogenase n=20 Tax=Bacteria RepID=LEU3_COLP3 Length = 362 Score = 423 bits (1087), Expect = e-117, Method: Composition-based stats. Identities = 223/359 (62%), Positives = 277/359 (77%), Gaps = 3/359 (0%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 +IA+L GDGIGPEVM +A KVL+ V ++F ITT YD+GGAAIDNHG LP +T+ GC Sbjct: 3 NIAILAGDGIGPEVMVEAKKVLNTVASKFDFEITTQDYDIGGAAIDNHGNALPDSTMAGC 62 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 ++DA+LFGSVGGPKW +LPP +QPER ALL LR HF LF N+RPA L L + LR+ Sbjct: 63 IESDAILFGSVGGPKWANLPPTEQPERCALLGLRSHFDLFCNMRPATLQPALSSLSTLRS 122 Query: 126 DIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARK 185 DI+ GFD+L +RELTG IYFG+PKGR G G+ E FD+ Y R E++RI+ +AF++A+K Sbjct: 123 DISEQGFDVLVIRELTGDIYFGEPKGRRGEGEEETGFDSMFYSRREVKRISHLAFQAAQK 182 Query: 186 RRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLLC 245 R +KVTS+DKANVL +S LWR++V E+A EYPDVEL H+Y+DNA MQL++DP+QFDV+LC Sbjct: 183 RNNKVTSVDKANVLATSQLWRQVVEEVAVEYPDVELEHLYVDNAAMQLVRDPNQFDVMLC 242 Query: 246 SNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSL 305 NLFGDILSD CAMITGSMG+LPSASLN GFG+YEPAGGSAPDIAG +ANPIAQILS Sbjct: 243 PNLFGDILSDICAMITGSMGLLPSASLNSDGFGMYEPAGGSAPDIAGLGVANPIAQILSA 302 Query: 306 ALLLRYSLDADDAACAIERAINRALEEGIRTGDL---ARGAAAVSTDEMGDIIARYVAE 361 AL+LRYSL+ AA AIE A++ AL+ G+ T DL A ST E+GD I + + Sbjct: 303 ALMLRYSLNQGAAAKAIEDAVSNALDNGVLTADLLPANERKNAKSTSEVGDYICKQIES 361 >UniRef50_Q9WZ26 3-isopropylmalate dehydrogenase n=47 Tax=Bacteria RepID=LEU3_THEMA Length = 354 Score = 422 bits (1086), Expect = e-117, Method: Composition-based stats. Identities = 202/357 (56%), Positives = 259/357 (72%), Gaps = 7/357 (1%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 IAVLPGDGIGPEV+ +ALKVL+ V + +GG AID G+PLP T + C Sbjct: 2 KIAVLPGDGIGPEVVREALKVLEVVEKKTGKTFEKVFGHIGGDAIDRFGEPLPEETKKIC 61 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 +ADA+ GSVGGPKW+ LPP+++PE G LL LRK L++N+RP K+Y+ L PL+ Sbjct: 62 LEADAIFLGSVGGPKWDDLPPEKRPEIGGLLALRKMLNLYANIRPIKVYRSLVHVSPLKE 121 Query: 126 DIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARK 185 + +G D++ VREL+ G+Y+GQP+G + EK FDT +Y R +ERIAR AFE A+ Sbjct: 122 KVIGSGVDLVTVRELSYGVYYGQPRGLD----EEKGFDTMIYDRKTVERIARTAFEIAKN 177 Query: 186 RRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLLC 245 RR KVTS+DKANVL SS+LWR++VNE+A EYPDVEL H+Y+DNA MQLI PSQFDV+L Sbjct: 178 RRKKVTSVDKANVLYSSMLWRKVVNEVAREYPDVELTHIYVDNAAMQLILKPSQFDVILT 237 Query: 246 SNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSL 305 +N+FGDILSDE A + GS+G+LPSAS ++ LYEPAGGSAPDIAGKNIANPIAQILSL Sbjct: 238 TNMFGDILSDESAALPGSLGLLPSASFGDKN--LYEPAGGSAPDIAGKNIANPIAQILSL 295 Query: 306 ALLLRYSLDADDAACAIERAINRALEEGIRTGDLARG-AAAVSTDEMGDIIARYVAE 361 A++L +S + A IERA+ +EEG RT D+A AVST +MGD+I + + E Sbjct: 296 AMMLEHSFGMVEEARKIERAVELVIEEGYRTRDIAEDPEKAVSTSQMGDLICKKLEE 352 >UniRef50_D1HRU7 3-isopropylmalate dehydrogenase (Fragment) n=2 Tax=Vitis vinifera RepID=D1HRU7_VITVI Length = 506 Score = 417 bits (1073), Expect = e-115, Method: Composition-based stats. Identities = 184/364 (50%), Positives = 247/364 (67%), Gaps = 4/364 (1%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPAT 61 K Y I +LPGDGIGPEV++ A VL + + VGG A+D G PLP T Sbjct: 141 PKRYSITLLPGDGIGPEVISVAKNVLKLAGSLEGIEFGFQEMPVGGCALDLTGVPLPEET 200 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 + +Q+DAVL G++GG KW+ +PE G LL LR K+F+NLRPA + L Sbjct: 201 LLVAKQSDAVLLGAIGGYKWDSNEKHLKPETG-LLQLRSGLKVFANLRPASVLPQLVDAS 259 Query: 122 PLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQ-YEKAFDTEVYHRFEIERIARIAF 180 L+ ++ A G D++ VRELTGGIYFG+P+G + E F+TEVY +EI+RIARIAF Sbjct: 260 TLKKEV-AEGVDLMVVRELTGGIYFGKPRGFSKNENGEEIGFNTEVYATYEIDRIARIAF 318 Query: 181 ESARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQF 240 E+A+KRR K+ S+DKANVL++S+LWR+ V +A+EYPDVEL+HMY+DNA MQL+++P QF Sbjct: 319 ETAQKRRGKLCSVDKANVLEASMLWRKRVTAMASEYPDVELSHMYVDNAAMQLVRNPKQF 378 Query: 241 DVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIA 300 D ++ +N+FGDILSDE +MITGS+GMLPSAS+ E G GL+EP GSAPDIAG++ ANP+A Sbjct: 379 DTIVTNNIFGDILSDEASMITGSIGMLPSASVGESGPGLFEPIHGSAPDIAGQDKANPLA 438 Query: 301 QILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAA-VSTDEMGDIIARYV 359 +LS A+LLRY L +AA IE A+ L+ G RT D+ V EMG+ + + V Sbjct: 439 TVLSAAMLLRYGLGEGNAAKRIETAVLDTLDRGFRTRDIYEAGTKLVGCKEMGEQVLKAV 498 Query: 360 AEGV 363 + Sbjct: 499 ESQI 502 >UniRef50_Q493R1 3-isopropylmalate dehydrogenase n=224 Tax=Bacteria RepID=LEU3_BLOPB Length = 366 Score = 412 bits (1058), Expect = e-113, Method: Composition-based stats. Identities = 227/361 (62%), Positives = 284/361 (78%), Gaps = 1/361 (0%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPA 60 M+ NYHIAVLPGDGIGPE Q K+L+ ++ +F + I T+ + +GG AI++ G P P + Sbjct: 1 MNNNYHIAVLPGDGIGPETTRQVYKILNVIKKQFQINIVTTEHKIGGDAINSEGTPFPKS 60 Query: 61 TVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAF 120 T++ CEQ++A+LFG+VGGP+W HL + PE+GALL LRKHF LF+NLRP L L+ Sbjct: 61 TLKYCEQSNAILFGAVGGPQWTHLKGSESPEQGALLALRKHFNLFANLRPIYLADELKEL 120 Query: 121 CPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAF 180 PL ++ NG DI+ VRELTGGIYFGQPKGR G+G E AFDT VYHRFEIERIA IAF Sbjct: 121 SPLNINMIPNGIDIIFVRELTGGIYFGQPKGRSGTGLNEYAFDTAVYHRFEIERIANIAF 180 Query: 181 ESARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQF 240 + A+KRR +V+SIDKANVL +S+LWRE+V+ +A YPDVEL H+YIDNA+MQLI +PS+F Sbjct: 181 KLAQKRRKRVSSIDKANVLHTSMLWREVVSHLAKNYPDVELEHLYIDNASMQLINNPSKF 240 Query: 241 DVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIA 300 D++LC NLFGDILSDECAMI+GS+GMLPSAS+NE FGLYEPAGGSAPDIA KNIANPIA Sbjct: 241 DIILCPNLFGDILSDECAMISGSIGMLPSASINEHNFGLYEPAGGSAPDIAEKNIANPIA 300 Query: 301 QILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLA-RGAAAVSTDEMGDIIARYV 359 ILS+ALL RYSL D A IE+A+++AL G RT D+A + ++ST+EMGDIIA + Sbjct: 301 HILSIALLFRYSLKLDHIAIKIEKAVSQALMLGYRTIDIAKKHEKSISTNEMGDIIAALI 360 Query: 360 A 360 Sbjct: 361 K 361 >UniRef50_Q9FMT1 3-isopropylmalate dehydrogenase 3, chloroplastic n=385 Tax=cellular organisms RepID=LEU33_ARATH Length = 409 Score = 403 bits (1035), Expect = e-111, Method: Composition-based stats. Identities = 188/364 (51%), Positives = 246/364 (67%), Gaps = 4/364 (1%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPAT 61 K Y+IA+LPGDGIGPEV++ A VL + + VGGAA+D G PLP T Sbjct: 44 KKRYNIALLPGDGIGPEVISVAKNVLQKAGSLEGLEFDFKEMPVGGAALDLVGVPLPEET 103 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 + +DA+L G++GG KW+ +PE AL LR+ K+F+NLRPA + L Sbjct: 104 FTAAKLSDAILLGAIGGYKWDKNEKHLRPEM-ALFYLRRDLKVFANLRPATVLPQLVDAS 162 Query: 122 PLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQ-YEKAFDTEVYHRFEIERIARIAF 180 L+ ++ A G D++ VRELTGGIYFG+P+G + E TE+Y EI+RIAR+AF Sbjct: 163 TLKKEV-AEGVDMMIVRELTGGIYFGEPRGITINENGEEVGVSTEIYAAHEIDRIARVAF 221 Query: 181 ESARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQF 240 E+ARKRR K+ S+DKANVL +SILWR+ V +A+EYPDVEL+HMY+DNA MQLI+DP QF Sbjct: 222 ETARKRRGKLCSVDKANVLDASILWRKRVTALASEYPDVELSHMYVDNAAMQLIRDPKQF 281 Query: 241 DVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIA 300 D ++ +N+FGDILSDE +MITGS+GMLPSASL E G GL+EP GSAPDIAG++ ANP+A Sbjct: 282 DTIVTNNIFGDILSDEASMITGSIGMLPSASLGESGPGLFEPIHGSAPDIAGQDKANPLA 341 Query: 301 QILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAA-VSTDEMGDIIARYV 359 ILS A+LL+Y L + AA IE A+ AL +G RTGD+ V EMG+ + + V Sbjct: 342 TILSAAMLLKYGLGEEKAAKRIEDAVVDALNKGFRTGDIYSPGNKLVGCKEMGEEVLKSV 401 Query: 360 AEGV 363 V Sbjct: 402 ESKV 405 >UniRef50_C9KJM9 3-isopropylmalate dehydrogenase n=1 Tax=Mitsuokella multacida DSM 20544 RepID=C9KJM9_9FIRM Length = 355 Score = 395 bits (1016), Expect = e-108, Method: Composition-based stats. Identities = 177/357 (49%), Positives = 245/357 (68%), Gaps = 4/357 (1%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 +Y I V+PGDGIG E+ A++VL+ V +F + ++ ++ D GG A D G PLP T+E Sbjct: 2 SYKITVIPGDGIGKEITDSAVEVLEKVDEKFGLGLSYTYKDAGGTAYDKFGTPLPDDTIE 61 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 C+ +D VLFG+VGG KW+++ P +PE+ A+L LRK+ L++NLRP K+ L + PL Sbjct: 62 ACKASDGVLFGAVGGDKWDNVDPALRPEK-AILGLRKNLGLYANLRPVKVADALVEYSPL 120 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 + ++ G D++ VREL GGIYFG E E+A+D E Y E++RIA++AFE+A Sbjct: 121 KPELV-KGVDLVIVRELIGGIYFGDKCESEQHNGAERAWDLENYSVPEVDRIAKLAFETA 179 Query: 184 RKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVL 243 + RR KVTS+DKANVL +S LWR V ++A YPDVEL ++Y+DN MQL P+QFDV+ Sbjct: 180 KLRRGKVTSVDKANVLATSRLWRRTVAKVAESYPDVELNNLYVDNCAMQLAIRPTQFDVI 239 Query: 244 LCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQIL 303 + NLFGDILSDE A++ GS+GM+PSAS+ LYEP GSAPDIAGK IANP+ IL Sbjct: 240 VTGNLFGDILSDEAAVVGGSIGMMPSASIGTS-TSLYEPIHGSAPDIAGKGIANPMGTIL 298 Query: 304 SLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGA-AAVSTDEMGDIIARYV 359 S A+LLRYSL + AA AIE A+++AL +G RT DL + +T+E+ +I + Sbjct: 299 SAAMLLRYSLHEEAAAKAIEAAVDKALADGYRTPDLWKEGFQKANTEEITKVICERI 355 >UniRef50_Q6GF15 3-isopropylmalate dehydrogenase n=94 Tax=Bacilli RepID=LEU3_STAAR Length = 348 Score = 390 bits (1002), Expect = e-107, Method: Composition-based stats. Identities = 166/356 (46%), Positives = 236/356 (66%), Gaps = 11/356 (3%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 Y+I LPGDGIGPE++ +L +L+ + N++ H++ GGA+ID G+PL T+ Sbjct: 2 TYNIVALPGDGIGPEILNGSLSLLEIISNKYNFNYQIEHHEFGGASIDTFGEPLTEKTLN 61 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 C++ADA+L G++GGPKW P+ +PE+G LL LRK LF+N+RP + +G + PL Sbjct: 62 ACKRADAILLGAIGGPKWTD--PNNRPEQG-LLKLRKSLNLFANIRPTTVVKGASSLSPL 118 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 +A+ G D++ VRELT GIYFG+P+ A D+ Y R EIERI +AF+ A Sbjct: 119 KAE-RVEGTDLVIVRELTSGIYFGEPRYFNNHE----ALDSLTYTREEIERIVHVAFKLA 173 Query: 184 RKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVL 243 RR K+TS+DK NVL SS LWR++VNE++ YP+V + H+ +D +M LI +P QFDV+ Sbjct: 174 ASRRGKLTSVDKENVLASSKLWRKVVNEVSQLYPEVTVNHLLVDACSMHLITNPKQFDVI 233 Query: 244 LCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQIL 303 + NLFGDILSDE ++I GS+G+ PSAS + G LYEP GSAPDIAGKN+ANP IL Sbjct: 234 VYENLFGDILSDEASVIPGSLGLSPSASFSNDGPRLYEPIHGSAPDIAGKNVANPFGMIL 293 Query: 304 SLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYV 359 SLA+ LR SL+ DAA +E+ I +E G T DL ++T ++ +I+++ + Sbjct: 294 SLAMCLRESLNQPDAADELEQHIYNMIEHGQTTADL---GGKLNTTDIFEILSQKL 346 >UniRef50_Q5SIY4 3-isopropylmalate dehydrogenase n=53 Tax=cellular organisms RepID=LEU3_THET8 Length = 345 Score = 388 bits (996), Expect = e-106, Method: Composition-based stats. Identities = 176/355 (49%), Positives = 236/355 (66%), Gaps = 11/355 (3%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 +AVLPGDGIGPEV ALKVL A+ + + + GGAAID G+P P T +G Sbjct: 2 KVAVLPGDGIGPEVTEAALKVLRALDEAEGLGLAYEVFPFGGAAIDAFGEPFPEPTRKGV 61 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 E+A+AVL GSVGGPKW+ LP +PE G LL LRK LF+NLRPAK++ GLE PL+ Sbjct: 62 EEAEAVLLGSVGGPKWDGLPRKIRPETG-LLSLRKSQDLFANLRPAKVFPGLERLSPLKE 120 Query: 126 DIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARK 185 +I A G D+L VRELTGGIYFG+P+G + A++TE Y + E+ER+AR+AFE+ARK Sbjct: 121 EI-ARGVDVLIVRELTGGIYFGEPRGMSEAE----AWNTERYSKPEVERVARVAFEAARK 175 Query: 186 RRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLLC 245 RR V S+DKANVL+ WR+ V E+ YPDV L H Y+D M L++ P++FDV++ Sbjct: 176 RRKHVVSVDKANVLEVGEFWRKTVEEVGRGYPDVALEHQYVDAMAMHLVRSPARFDVVVT 235 Query: 246 SNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSL 305 N+FGDILSD +++ GS+G+LPSASL +G ++EP GSAPDIAGK IANP A ILS Sbjct: 236 GNIFGDILSDLASVLPGSLGLLPSASLG-RGTPVFEPVHGSAPDIAGKGIANPTAAILSA 294 Query: 306 ALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYVA 360 A++L ++ + A +E A+ +AL E DL + T+ + R++A Sbjct: 295 AMMLEHAFGLVELARKVEDAVAKALLE-TPPPDL---GGSAGTEAFTATVLRHLA 345 >UniRef50_Q55BI2 Isocitrate dehydrogenase [NAD] regulatory subunit A, mitochondrial n=35 Tax=Eukaryota RepID=IDHA_DICDI Length = 354 Score = 384 bits (986), Expect = e-105, Method: Composition-based stats. Identities = 119/365 (32%), Positives = 174/365 (47%), Gaps = 36/365 (9%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPAT 61 SK + ++PGDGIGPE+ +V AV+ + G + Sbjct: 21 SKIQKVTLIPGDGIGPEISESVKRVFSAVKAPIEWETVVVDANTG----------ISKEV 70 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 +E + L G + P + L LRK F L++N+RP G Sbjct: 71 IESISKNKIGLKGPISTPIGTG-------HQSLNLGLRKTFNLYANIRPCLSIPG----- 118 Query: 122 PLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFE 181 N + + VRE T G Y G E A ++ + RIA AF+ Sbjct: 119 ---HKTRYNNVNTVVVRENTEGEYSG----IENQPVKGVAQSIKIITKEASTRIAHYAFQ 171 Query: 182 SARKR-RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQ 239 A R KVT I KAN+++ S L+ + E++T YP ++ + IDN MQL+ DP+Q Sbjct: 172 YALANGRKKVTCIHKANIMKQSDGLFVKSCREVSTRYPSIKYEELTIDNNCMQLVLDPNQ 231 Query: 240 FDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPI 299 DV++ NL+GDI+SD CA + G +G+ PS ++ E G ++E G+APDIAGKN ANP Sbjct: 232 MDVMVLPNLYGDIVSDLCAGLIGGLGLTPSGNIGENGSAIFEAVHGTAPDIAGKNKANPT 291 Query: 300 AQILSLALLLRYSLDADDAACAIERAINRALEEG-IRTGDLARGAAAVSTDEMGDIIARY 358 A ILS ++LR+ L A IE A+ L EG ++TGDL S E D + + Sbjct: 292 ALILSSIMMLRH-LGHFHEASIIENAVLNTLTEGKVKTGDL---GGNSSCSEYTDELVKK 347 Query: 359 VAEGV 363 + E + Sbjct: 348 ITESL 352 >UniRef50_Q1IJA8 Isocitrate dehydrogenase (NAD+) n=19 Tax=Bacteria RepID=Q1IJA8_ACIBL Length = 348 Score = 381 bits (978), Expect = e-104, Method: Composition-based stats. Identities = 120/362 (33%), Positives = 180/362 (49%), Gaps = 31/362 (8%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 Y I ++PGDGIGPEV + A++VL+A ++ + G A + + + +P E Sbjct: 2 TYKITLIPGDGIGPEVTSAAVRVLEA----TGLKFEWESFAAGAEAYEKYKEYIPKELNE 57 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 E+ L G V P + LRK F+L++N+RP + G+ Sbjct: 58 SIERTRIGLKGPVTTPIGGGFS-------SINVELRKRFELYANVRPIRNLPGV------ 104 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 G D++ VRE T G+Y G ++ RI++ AF A Sbjct: 105 --HTRYPGVDLVVVRENTEGLYSGIEHEV----VPGVVESLKIITEKASTRISKFAFNYA 158 Query: 184 RK-RRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFD 241 RK R K+ SI KAN+++ S L+ I+ EYP++ +DN MQL+ +P Q+D Sbjct: 159 RKMGRKKIHSIHKANIMKMSDGLFIRCSRNISKEYPEIIYGEHIVDNTCMQLVMNPYQYD 218 Query: 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQ 301 +LL NL+GDI+SD CA + G +G+ P A++ + ++E GSAPDIAGKNIANP A Sbjct: 219 ILLLENLYGDIVSDLCAGLVGGLGLAPGANIG-ERASIFEAVHGSAPDIAGKNIANPTAV 277 Query: 302 ILSLALLLRYSLDADDAACAIERAINRALEEGIR-TGDLARGAAAVSTDEMGDIIARYVA 360 I S L+LR+ LD DAA ++ A++ EG T D+ ST E D + + Sbjct: 278 IRSGILMLRH-LDEQDAANRVKAAVHHVYREGKHLTRDM---GGTTSTSEFADKVVEAIH 333 Query: 361 EG 362 Sbjct: 334 SK 335 >UniRef50_Q4FP17 3-isopropylmalate dehydrogenase n=11 Tax=cellular organisms RepID=LEU3_PELUB Length = 368 Score = 380 bits (975), Expect = e-104, Method: Composition-based stats. Identities = 169/366 (46%), Positives = 233/366 (63%), Gaps = 10/366 (2%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATV 62 K I +LPGDGIGPEV+ + KV+ + + ++ GG + D HG P+ Sbjct: 5 KKRKILLLPGDGIGPEVIQEVKKVILWLNSNKSLDFEIDEDLAGGCSYDKHGTPITDEVF 64 Query: 63 EGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 +++ V+ G+VGGPKW++L ++PER L K KLF+NLRPA ++ L Sbjct: 65 YKALESEFVMLGAVGGPKWDNLEFSKKPERALLKLR-KELKLFANLRPAICFEQLVDAST 123 Query: 123 LRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYE-KAFDTEVYHRFEIERIARIAFE 181 L+ +I + G DI+ VRELTGGIYFG+P+G + E K +T Y EI R+A++AF+ Sbjct: 124 LKPEIVS-GLDIMIVRELTGGIYFGEPRGIKPIENGERKGINTHSYTTSEIVRVAKVAFD 182 Query: 182 SARKRRHKVTSIDKANVLQSSILWREIVNEIA-TEYPDVELAHMYIDNATMQLIKDPSQF 240 ARKR ++VTS +K+NV+++ LW+E V E+ EY DVEL+HM DN MQL+K+P QF Sbjct: 183 LARKRSNRVTSCEKSNVMEAGQLWKEEVQELHDKEYKDVELSHMLADNCAMQLLKNPKQF 242 Query: 241 DVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGF-----GLYEPAGGSAPDIAGKNI 295 DV++ NLFGD+LSD+ +M+TGS+G+LPSASL + +YEP GSAPDIAGK I Sbjct: 243 DVIVTDNLFGDMLSDQASMLTGSLGLLPSASLGAKNKDGEMRAMYEPIHGSAPDIAGKEI 302 Query: 296 ANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAA-VSTDEMGDI 354 ANPIA ILS A+ LRYSLD D A A+E+A+ L +G+RT D+ VST MGD Sbjct: 303 ANPIASILSFAMALRYSLDLDSEADALEKAVQDVLNDGLRTKDILSQGKKEVSTSAMGDA 362 Query: 355 IARYVA 360 I + Sbjct: 363 IISKLQ 368 >UniRef50_Q81G11 3-isopropylmalate dehydrogenase n=105 Tax=Bacteria RepID=LEU3_BACCR Length = 354 Score = 380 bits (975), Expect = e-104, Method: Composition-based stats. Identities = 168/357 (47%), Positives = 217/357 (60%), Gaps = 13/357 (3%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 I L GDG+GPEVM A +VL V + GG AID GQPLP T+ C Sbjct: 4 RIVCLAGDGVGPEVMESAKEVLHMVERLYGHHFHLQDEYFGGVAIDLTGQPLPQRTLAAC 63 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 +DAVL G+VGGP+W+ +PE+G LL LRK +F+N+RP + PL+ Sbjct: 64 LASDAVLLGAVGGPRWDSAKE--RPEKG-LLALRKGLGVFANVRPVTVESATAHLSPLKN 120 Query: 126 DIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARK 185 A+ D + VRELTGGIYF PK R E A DT YHR EIERI AF+ A K Sbjct: 121 ---ADEIDFVVVRELTGGIYFSYPKER----TEEVATDTLTYHRHEIERIVSYAFQLANK 173 Query: 186 RRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLLC 245 R+ KVTSIDKANVL+SS LWR + E+A YP+VE+ H+ +D A M+LI++P +FDV++ Sbjct: 174 RKKKVTSIDKANVLESSKLWRTVTEEVALRYPNVEVEHILVDAAAMELIRNPGRFDVIVT 233 Query: 246 SNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSL 305 NLFGDILSDE +++ GS+GMLPSAS E+G LYEP GSAPDIAGKN ANPIA + S+ Sbjct: 234 ENLFGDILSDEASVLAGSLGMLPSASHAEKGPSLYEPIHGSAPDIAGKNKANPIAMMRSV 293 Query: 306 ALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYVAEG 362 A++L S AIE A++ L+ G T D+ +T + + + E Sbjct: 294 AMMLGQSFGLTREGYAIEEAVSAVLKSGKCTADI---GGTETTTSFTKAVIQEMEEQ 347 >UniRef50_O29627 3-isopropylmalate dehydrogenase n=91 Tax=cellular organisms RepID=LEU3_ARCFU Length = 326 Score = 378 bits (972), Expect = e-103, Method: Composition-based stats. Identities = 131/356 (36%), Positives = 202/356 (56%), Gaps = 35/356 (9%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 I V+PGDGIG EVM A+ +L+ + + S+YD G A++ +G+ LP T+E C Sbjct: 3 KIVVIPGDGIGKEVMEAAMLILE----KLDLPFEYSYYDAGDEALEKYGKALPDETLEAC 58 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 ++DAVLFG+ G + ++ LR+ F+N+RPAK +G+E P Sbjct: 59 RKSDAVLFGAAG-----------ETAADVIVRLRRELGTFANVRPAKAIEGIECLYP--- 104 Query: 126 DIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA-R 184 G DI+ VRE T +Y G G + V R ERIAR AFE A R Sbjct: 105 -----GLDIVVVRENTECLYMGFEFGF-----GDVTEAIRVITREASERIARYAFELAKR 154 Query: 185 KRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVL 243 + R KVT++ KANV++ + L+R++ E+A +YP+++ YID A M L+ DP +FDV+ Sbjct: 155 EGRKKVTALHKANVMKKTCGLFRDVCREVAKDYPEIQYNDYYIDAACMYLVMDPFRFDVI 214 Query: 244 LCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQIL 303 + +N+FGDI+SD A + G +G+ PSA++ + ++EP G+A DIAGK IANP A IL Sbjct: 215 VTTNMFGDIVSDLAAGLVGGLGLAPSANVG-ERTAIFEPVHGAAFDIAGKGIANPTAMIL 273 Query: 304 SLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYV 359 + ++LR+ + A +E A+ + ++EG +T DL + T E + +A + Sbjct: 274 TACMMLRH-FGYVEEAKKVEEAVEKTIKEGKKTPDL---GGNLKTMEFANEVASLL 325 >UniRef50_C4Q3D3 Unc-13 (Munc13), putative n=38 Tax=cellular organisms RepID=C4Q3D3_SCHMA Length = 2313 Score = 378 bits (971), Expect = e-103, Method: Composition-based stats. Identities = 102/360 (28%), Positives = 173/360 (48%), Gaps = 31/360 (8%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 +A++PGDGIGPE+ ++ + I DV ++ +P ++++ Sbjct: 1978 TVALIPGDGIGPEISAAVQEIFKFA----DVPIKWESVDVTPRPTEDGRFRMPQSSLDII 2033 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 + L G + P + + L LRK F L++N+RP K +G E Sbjct: 2034 RKHGIGLKGPLATPIG-------KGHQSLNLALRKEFNLYANVRPCKSIEGYETPY---- 2082 Query: 126 DIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARK 185 D++ VRE T G Y G ++ R+AR AF+ A+ Sbjct: 2083 ----KNVDLVTVRENTEGEYSGIEHVI----VDGVVQSIKLITEEASRRVARFAFQYAKD 2134 Query: 186 RRHK-VTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVL 243 + VT++ KAN+++ S L+ + E A + ++E M++D + L++DP++FDVL Sbjct: 2135 NGRRSVTAVHKANIMRMSDGLFLRVCREEAAHHREIEFCDMFLDTVCLNLVQDPTRFDVL 2194 Query: 244 LCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQIL 303 + NL+GDILSD A + G +G+ PS ++ E G ++E G+APDIAG++ ANP A + Sbjct: 2195 VMPNLYGDILSDLAAGLIGGLGVTPSGNIGETG-AIFESVHGTAPDIAGQDRANPTALLF 2253 Query: 304 SLALLLRYSLDADDAACAIERAINRALEE-GIRTGDLARGAAAVSTDEMGDIIARYVAEG 362 S ++LRY ++ + A IE A+ + E T DL + + I R + + Sbjct: 2254 SAIMMLRY-MNLNKHADLIESAVLATIREAKYLTADL---GGRSTCSQYTKEICRQIEQK 2309 >UniRef50_Q5HMF8 3-isopropylmalate dehydrogenase n=9 Tax=Bacilli RepID=LEU3_STAEQ Length = 347 Score = 377 bits (968), Expect = e-103, Method: Composition-based stats. Identities = 161/355 (45%), Positives = 223/355 (62%), Gaps = 11/355 (3%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 +Y I LPGDGIGPE+++ L++L + ++ + GG +ID +G PL T++ Sbjct: 2 SYKIVALPGDGIGPEILSGTLELLKLISEKYHFEYHLESHHFGGVSIDYYGTPLTNETLQ 61 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 C+ ADA+L G++GGPKW P+ +PE G LL LRK LF+N+RP + +G PL Sbjct: 62 SCKNADAILLGAIGGPKWTD--PNNRPEHG-LLKLRKSLNLFANIRPTFVTKGASHLSPL 118 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 + DI G D++ VRELT GIYFG+P + + A D+ Y EIERI RIAF A Sbjct: 119 KQDIV-EGTDLVIVRELTSGIYFGEPSYVKKTE----ALDSLKYSSQEIERIVRIAFNLA 173 Query: 184 RKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVL 243 +RR K+TS+DK NVL SS LWR+IVN++ +YP+VE+ HM +D +M LI P+QFDV+ Sbjct: 174 NRRRKKLTSVDKENVLSSSKLWRQIVNDVKKDYPEVEVNHMLVDACSMHLITQPTQFDVI 233 Query: 244 LCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQIL 303 + NLFGDILSDE ++I GS+G+ PSAS + G LYEP GSAPDIA ++ ANP +L Sbjct: 234 VTENLFGDILSDEASVIPGSLGLSPSASFGQTGTRLYEPIHGSAPDIANEDKANPFGMVL 293 Query: 304 SLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARY 358 SLAL LR SL+ +DAA +E + ++ T DL T E+ ++ Sbjct: 294 SLALCLRESLNQNDAANELESIVYSFIQSNKTTADL---GGQYRTSEIFKLLKEK 345 >UniRef50_Q2JUI3 Isopropylmalate/isohomocitrate dehydrogenase family protein n=19 Tax=Bacteria RepID=Q2JUI3_SYNJA Length = 368 Score = 377 bits (968), Expect = e-103, Method: Composition-based stats. Identities = 122/375 (32%), Positives = 184/375 (49%), Gaps = 39/375 (10%) Query: 5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEG 64 Y + ++PGDGIGPEV VL+A + + + G I+ +G PLPP +E Sbjct: 3 YRVTLIPGDGIGPEVTRAMTTVLEA----SGVDLEWIRVEAGVEVIEKYGTPLPPQVLES 58 Query: 65 CEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 + + G +G P R + +RK L++NLRPAK G+++ Sbjct: 59 IRETRVAIKGPIGTPVGTGF-------RSVNVAIRKELDLYANLRPAKSLPGIKSP---- 107 Query: 125 ADIAANGFDILCVRELTGGIYFGQPKGREGSGQ----------------YEKAFDTEVYH 168 D++ VRE T +Y G R A + Sbjct: 108 ----FQDIDLVVVRENTEDLYAGIEFERGTPEAAHAREEMMRLSGKFIREGSAIGIKPIS 163 Query: 169 RFEIERIARIAFESARKR-RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYI 226 F RI + AFE AR+ R KVT++ KAN+++ + L+ ++ E+A EYPD+E + + Sbjct: 164 EFGSRRIVKFAFEYARQNGRKKVTAVHKANIMKFTDGLFLQVAREVAQEYPDIEFEDLIV 223 Query: 227 DNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGS 286 DN +QL++ P +DVL+ +NL+GDI+SD CA + G +G+ P A++ + G ++E GS Sbjct: 224 DNMCLQLMQKPQLYDVLVLTNLYGDIISDLCAGMIGGLGVAPGANIGD-GIAVFEAIHGS 282 Query: 287 APDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAV 346 AP AG+N NP A ILS A++LRY + + AA + E T DLA V Sbjct: 283 APKYAGQNKVNPSALILSGAMMLRYLGEREAAARVEAAVQSVIAEGKYVTYDLA-QGEPV 341 Query: 347 STDEMGDIIARYVAE 361 T EM + IA V E Sbjct: 342 GTQEMAEAIAARVQE 356 >UniRef50_Q2YL58 3-isopropylmalate dehydrogenase n=285 Tax=cellular organisms RepID=LEU3_BRUA2 Length = 370 Score = 377 bits (968), Expect = e-103, Method: Composition-based stats. Identities = 178/366 (48%), Positives = 229/366 (62%), Gaps = 11/366 (3%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 + + +LPGDGIGPE M + KV+ + + + T VGG A D HGQ + A +E Sbjct: 3 SRKLLLLPGDGIGPEAMAEVRKVIAFLNSDLNLGFETEEGLVGGCAYDAHGQAISDADME 62 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 AD+VLFG+VGGPKW+ +P + +PE G LL LRK +L++NLRPA Y L L Sbjct: 63 KALAADSVLFGAVGGPKWDSVPYEVRPEAG-LLRLRKDMQLYANLRPAICYPALAHSSSL 121 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQ-YEKAFDTEVYHRFEIERIARIAFES 182 + ++ G DIL +RELTGG+YFG+PK G ++ DT+VY +EIERIA +AFE Sbjct: 122 KPEVI-EGLDILILRELTGGVYFGEPKEIIDLGNGQKRGIDTQVYDTYEIERIADVAFEL 180 Query: 183 ARKRRHKVTSIDKANVLQSSILWREIVNEIATE-YPDVELAHMYIDNATMQLIKDPSQFD 241 AR RR+KVTS++K NV++S +LW + V E + DV+L HM D MQL++ P QFD Sbjct: 181 ARTRRNKVTSMEKRNVMKSGVLWNQGVTARHKEKHADVQLEHMLADAGGMQLVRWPKQFD 240 Query: 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNE------QGFGLYEPAGGSAPDIAGKNI 295 V+L NLFGD+LSD AM+TGS+GMLPSASL + LYEP GSAPDIAGK I Sbjct: 241 VILTDNLFGDLLSDVAAMLTGSLGMLPSASLGAADSKTGKRKALYEPVHGSAPDIAGKGI 300 Query: 296 ANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGA-AAVSTDEMGDI 354 ANPIA I SLA+ LRYS A +E AI L++GIRT D+ V T EMGD Sbjct: 301 ANPIAMIASLAMCLRYSFGLVAEADRLEAAIAGVLDDGIRTADIWSEGNTKVGTTEMGDA 360 Query: 355 IARYVA 360 I Sbjct: 361 ILAKFK 366 >UniRef50_B1I496 3-isopropylmalate dehydrogenase n=4 Tax=Bacteria RepID=B1I496_DESAP Length = 364 Score = 376 bits (966), Expect = e-103, Method: Composition-based stats. Identities = 136/362 (37%), Positives = 193/362 (53%), Gaps = 13/362 (3%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPA 60 M K Y IAV+PGDG GPE + + LKVL A + + T+ D GG G+ LPP Sbjct: 13 MQKTYKIAVIPGDGTGPEQVREGLKVLHAAAGKEGFALETTVLDWGGEYYLRTGEVLPPD 72 Query: 61 TVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAF 120 VE ++ DA+ G++G P+ E+G LL LR + NLRP KLY G+E Sbjct: 73 AVEQLKRYDAIYLGAIGHPE----VRPGILEKGILLRLRFELDQYINLRPVKLYPGVETP 128 Query: 121 CPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAF 180 + D + VRE T G+Y G + E A T + R +ER R AF Sbjct: 129 IAGKG---PEDIDFVVVRENTEGLYAGSGGFLKRGTPDEVAIQTSINTRKGVERCVRFAF 185 Query: 181 ESARKR--RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDP 237 E RKR R KVT K NVL + LW + NE+ EYPD+E + ++D M ++K+P Sbjct: 186 EYCRKRGGRRKVTLCGKTNVLTFAFDLWERVFNEVGEEYPDIERDYAHVDAICMWMVKNP 245 Query: 238 SQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIAN 297 FDV++ N+FGDI++D AM+ G MG+ +LN +G ++EP GGSAP GKN+ N Sbjct: 246 EWFDVIVTDNMFGDIITDLGAMLQGGMGIAAGGNLNPEGVSMFEPIGGSAPKYTGKNVIN 305 Query: 298 PIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIAR 357 P+A + + A++L L AA IE A+ + + LA G TDE+GD++ Sbjct: 306 PLAAVCAGAMMLE-QLGETGAAARIEEAVKKVCAGHL--KSLAAGRMGYGTDEVGDLVVS 362 Query: 358 YV 359 ++ Sbjct: 363 HL 364 >UniRef50_Q46NL2 Tartrate dehydrogenase n=12 Tax=Bacteria RepID=Q46NL2_RALEJ Length = 358 Score = 375 bits (964), Expect = e-102, Method: Composition-based stats. Identities = 131/364 (35%), Positives = 190/364 (52%), Gaps = 17/364 (4%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPAT 61 ++ Y IAV+PGDGIG EV+ + ++VL+A +F ++ + YD A + G +P Sbjct: 4 NQQYKIAVIPGDGIGNEVVPEGIRVLEAASAKFGFKLAFTTYDWSCARYHSQGSMMPSDG 63 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 +E +DA+ G+VG P PD L+P+R+ F + NLRP +L G+ Sbjct: 64 IERLRDSDAIFLGAVGFPG----VPDHVSLWNLLIPIRREFDQYVNLRPVRLLPGVPCPL 119 Query: 122 PLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFE 181 + D VRE T G Y ++E ++ R +RI R AF+ Sbjct: 120 ANK---KPGDIDFWIVRENTEGEYSQVGGRMFAGTEHEFVTQEAIFTRRGTDRIMRYAFD 176 Query: 182 SARK-RRHKVTSIDKAN-VLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQ 239 A+K R+ VTS K+N + S W E + EYPD+ +ID + P + Sbjct: 177 LAKKLGRNHVTSATKSNGIFHSMPFWDERFAAVGAEYPDIRTDQYHIDILAARFAMSPER 236 Query: 240 FDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQ--GFGLYEPAGGSAPDIAGKNIAN 297 FDV++ SNLFGDILSD ITG++ + PSA++N + ++EP GSAPDIAG+ IAN Sbjct: 237 FDVVVGSNLFGDILSDLGPGITGTIAVAPSANINPERKYPSMFEPVHGSAPDIAGQGIAN 296 Query: 298 PIAQILSLALLLRYSLDADDAACAIERAINRALE--EGIRTGDLARGAAAVSTDEMGDII 355 PI QI S A++L + L +AA AI +AI L + + T DL ST +MG I Sbjct: 297 PIGQIWSGAMMLEH-LGQPEAAAAIMQAIETVLTHPDRVHTPDL---GGRASTQQMGAEI 352 Query: 356 ARYV 359 AR V Sbjct: 353 ARAV 356 >UniRef50_A3P147 Tartrate dehydrogenase n=59 Tax=Bacteria RepID=A3P147_BURP0 Length = 396 Score = 375 bits (963), Expect = e-102, Method: Composition-based stats. Identities = 140/368 (38%), Positives = 192/368 (52%), Gaps = 18/368 (4%) Query: 1 MSKN-YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDV-GGAAIDNHGQPLP 58 MS+ Y IAV+PGDGIG EVM + L+ LDAV RF +R + HGQ +P Sbjct: 36 MSEKVYRIAVIPGDGIGVEVMPEGLRALDAVSRRFGLRFAYEPIEWASCDYYAKHGQMMP 95 Query: 59 PATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLE 118 DA+LFG+VG P+ PD G+L+ R+ F + NLRPA+L+ G+ Sbjct: 96 DDWKTQLSGMDALLFGAVGWPE---TVPDHISLWGSLIKFRREFDQYVNLRPARLFDGVP 152 Query: 119 AFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARI 178 A A D + VRE T G Y + E V+ R ER+ + Sbjct: 153 CPL---AGRKAGDIDFMIVRENTEGEYSAVGGTMFEGTEREFVVQQAVFTRHGTERVLKF 209 Query: 179 AFESARKRRHKVTSIDKAN-VLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDP 237 AFE A++R ++T K+N + S W E+A YPDV +ID + + P Sbjct: 210 AFELAQRRAKRLTVATKSNGIAISMPWWDARAAEMAARYPDVAWDKQHIDILCARFVMQP 269 Query: 238 SQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQG--FGLYEPAGGSAPDIAGKNI 295 +FDV++ SNLFGDILSD TG++G+ PSA+LN + L+EP GSAPDIAGK+I Sbjct: 270 DRFDVVVASNLFGDILSDLGPACTGTIGIAPSANLNPERNFPSLFEPVHGSAPDIAGKHI 329 Query: 296 ANPIAQILSLALLLRYS----LDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEM 351 ANPIA I S A+++ + A +A AI AI L+ G RT D+ ST E+ Sbjct: 330 ANPIAMIWSAAMMVDFLGAGTGPAREAHDAIVAAIEHVLKHGPRTRDM---GGRASTREV 386 Query: 352 GDIIARYV 359 GD I ++ Sbjct: 387 GDAIVAHL 394 >UniRef50_P50213 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial n=91 Tax=cellular organisms RepID=IDH3A_HUMAN Length = 366 Score = 374 bits (960), Expect = e-102, Method: Composition-based stats. Identities = 110/358 (30%), Positives = 170/358 (47%), Gaps = 30/358 (8%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 + ++PGDGIGPE+ +K+ DA + I +V +P E Sbjct: 33 TVTLIPGDGIGPEISAAVMKIFDAAKA----PIQWEERNVTAIQGPGGKWMIPSEAKESM 88 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 ++ L G + P P L LRK F L++N+RP +G + Sbjct: 89 DKNKMGLKGPLKTPIAAGHP-------SMNLLLRKTFDLYANVRPCVSIEGYKTPYT--- 138 Query: 126 DIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARK 185 +I+ +RE T G Y G ++ +RIA AFE AR Sbjct: 139 -----DVNIVTIRENTEGEYSGIEHVI----VDGVVQSIKLITEGASKRIAEFAFEYARN 189 Query: 186 R-RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVL 243 R VT++ KAN+++ S L+ + E+A D++ MY+D + +++DPSQFDVL Sbjct: 190 NHRSNVTAVHKANIMRMSDGLFLQKCREVAESCKDIKFNEMYLDTVCLNMVQDPSQFDVL 249 Query: 244 LCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQIL 303 + NL+GDILSD CA + G +G+ PS ++ G ++E G+APDIAGK++ANP A +L Sbjct: 250 VMPNLYGDILSDLCAGLIGGLGVTPSGNIGANGVAIFESVHGTAPDIAGKDMANPTALLL 309 Query: 304 SLALLLRYSLDADDAACAIERAINRALEEGI-RTGDLARGAAAVSTDEMGDIIARYVA 360 S ++LR+ + D A IE A +++G T DL + + I R V Sbjct: 310 SAVMMLRH-MGLFDHAARIEAACFATIKDGKSLTKDL---GGNAKCSDFTEEICRRVK 363 >UniRef50_Q2J3B4 3-isopropylmalate dehydrogenase n=132 Tax=Bacteria RepID=LEU3_RHOP2 Length = 370 Score = 371 bits (952), Expect = e-101, Method: Composition-based stats. Identities = 170/366 (46%), Positives = 234/366 (63%), Gaps = 11/366 (3%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 + + +LPGDGIG EVM + +++D + T H VGGAA D + AT+ Sbjct: 3 THKLLLLPGDGIGTEVMAEVSRLIDWLNKAGIASFETEHGLVGGAAYDADKVAITDATMA 62 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 + +DAV+FG+VGGPKW+ +P D +PE G LL LRK LF+NLRPA Y L L Sbjct: 63 LAQASDAVIFGAVGGPKWDAVPYDARPEAG-LLRLRKDLALFANLRPAVCYPALAEASSL 121 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQ-YEKAFDTEVYHRFEIERIARIAFES 182 + ++ G DI+ VRELTGG+YFG+PK G ++A DT+VY +EIERI R+AF+ Sbjct: 122 KPEVV-EGLDIMIVRELTGGVYFGEPKTITDLGNGQKRAIDTQVYDTYEIERIGRVAFDL 180 Query: 183 ARKRRHKVTSIDKANVLQSSILWREIVNEI-ATEYPDVELAHMYIDNATMQLIKDPSQFD 241 ARKRR+KVTS++K NV+++ +LW E++ ++ A EY DV+L H D+ M L+K P QFD Sbjct: 181 ARKRRNKVTSMEKRNVMKTGVLWNEVITQVHAREYKDVQLEHQLADSGGMNLVKWPKQFD 240 Query: 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNE------QGFGLYEPAGGSAPDIAGKNI 295 V++ NLFGD+LSD AM+TGS+GMLPSASL + +YEP GSAPDIAGK + Sbjct: 241 VIVTDNLFGDMLSDIAAMLTGSLGMLPSASLGAVDDTTGKRKAMYEPVHGSAPDIAGKGL 300 Query: 296 ANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGA-AAVSTDEMGDI 354 ANP+A + S + LRYSLD + A ++ AI L G+RT D+ VST +MG+ Sbjct: 301 ANPVAMLASFGMALRYSLDMGELADKLDEAIAVVLARGLRTADIKSEGSTVVSTSQMGEA 360 Query: 355 IARYVA 360 I + + Sbjct: 361 IVQEMQ 366 >UniRef50_Q46FW0 3-isopropylmalate dehydrogenase n=11 Tax=Euryarchaeota RepID=Q46FW0_METBF Length = 338 Score = 370 bits (951), Expect = e-101, Method: Composition-based stats. Identities = 125/358 (34%), Positives = 193/358 (53%), Gaps = 29/358 (8%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 +AV+ GDGIG E++ A+KVLDA F + ++G + G + +E Sbjct: 2 RLAVIEGDGIGREIIPAAVKVLDA----FGLEFEKVPLELGYTRWERTGTAISNNDLETI 57 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 + DAVLFG++ + LL +RK L++N+RP K G+ Sbjct: 58 KGCDAVLFGAITT-------VPDPNYKSVLLTIRKELDLYANVRPVKPLPGITGV----- 105 Query: 126 DIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARK 185 N FD + VRE T G+Y G + E ++ V R ERIA A + A+K Sbjct: 106 -TGRNDFDFIIVRENTEGLYSGIEE-----IGPELSWTKRVVTRKGSERIAEYACKLAKK 159 Query: 186 RRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLLC 245 R++K+T + K+NVL+S L+ ++ + A+ VE M +D+ LI P ++D+++ Sbjct: 160 RKNKLTIVHKSNVLKSDKLFLDVCRQTASA-NGVEYEDMLVDSMAYNLIMRPERYDIVVT 218 Query: 246 SNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSL 305 +NLFGDILSD CA + GS+G++PSA++ E+ + +EP GSAPDIAGK IANP+A IL + Sbjct: 219 TNLFGDILSDMCAALVGSLGLVPSANIGEK-YAFFEPVHGSAPDIAGKGIANPLAAILCV 277 Query: 306 ALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYVAEGV 363 +LL + + + I+ AI L++ I T DL ST E+G+ +A YV + Sbjct: 278 KMLLEWMGEPR--SQIIDEAIAYVLQKKIITPDL---GGTASTMEVGNAVAEYVLSNI 330 >UniRef50_D0J9Z6 3-isopropylmalate dehydrogenase n=7 Tax=Bacteroidetes RepID=D0J9Z6_BLASP Length = 353 Score = 370 bits (949), Expect = e-101, Method: Composition-based stats. Identities = 155/361 (42%), Positives = 229/361 (63%), Gaps = 11/361 (3%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPA 60 M KN I V+ GDGIGPEV+ QA+K L+++ NRF + + G AI+ G P+P Sbjct: 1 MKKN--IVVIEGDGIGPEVIKQAIKALNSIGNRFHHEFSYQNVLAGAKAIETFGDPMPKE 58 Query: 61 TVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAF 120 T++ C ++DAVLFGS+G PK++ P +PE G LL LRK L+ N+RP Y G+ Sbjct: 59 TIDSCLKSDAVLFGSIGDPKYDSYPRGMRPEDG-LLKLRKEMDLYCNIRPIVTYPGINK- 116 Query: 121 CPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAF 180 + G + + RELTGGIYFG+ + + A+D VY EIERI ++F Sbjct: 117 -SPIKERKLEGVNFVIYRELTGGIYFGKKGRSKNGKE---AYDYCVYSEKEIERIGEMSF 172 Query: 181 ESARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQF 240 ++AR R K+T +DKANVL++S LWRE++ ++A +Y DV+L +YIDNA MQ++ +P +F Sbjct: 173 KAARSRNRKMTLVDKANVLETSRLWREVIQKMALDYSDVDLEFLYIDNAAMQILINPRKF 232 Query: 241 DVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIA 300 DV+L N+FGDILSDE +++T S+G+LPSAS+ + L+EP GS P GKNIANP+ Sbjct: 233 DVILTDNMFGDILSDEASILTSSLGLLPSASIGSK-KSLFEPIHGSYPQAKGKNIANPLG 291 Query: 301 QILSLALLLRYSLDADDAACAIERAINRALEEGIRTGD-LARGAAAVSTDEMGDIIARYV 359 ILS++++L Y + +E A+ +++E I T D + + ST+E+GD I +Y+ Sbjct: 292 CILSVSMMLEY-FEMPQEKNLLEEAVKSSIQEKICTPDIILDDRNSSSTEEVGDYIEKYI 350 Query: 360 A 360 Sbjct: 351 K 351 >UniRef50_D2EFL9 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Parvarchaeum acidiphilum ARMAN-4 RepID=D2EFL9_9EURY Length = 339 Score = 370 bits (949), Expect = e-101, Method: Composition-based stats. Identities = 121/360 (33%), Positives = 191/360 (53%), Gaps = 25/360 (6%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPAT 61 +K + +AV+ GDG+GP+V+ +L VLDAV+ +F + I G ++ +G LP T Sbjct: 3 NKKWRVAVIKGDGVGPDVINASLLVLDAVKKKFNLDIEYVPAVAGLNTVEKYGTNLPKET 62 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 ++ ++ D VL G P+ + P A + +RK+F L++++RP K + + Sbjct: 63 LDTLKETDCVLKGPTTTPEGANSLP------SANVGIRKYFDLYADVRPNKTLPNVPSIK 116 Query: 122 PLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFE 181 P D++ VRE T G+Y G E V R ERI + AF+ Sbjct: 117 P--------NVDMVIVRENTEGMYSGLDFRV----NQETTIGIRVITRKACERIVKYAFK 164 Query: 182 SARKRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQF 240 A R+ VT + K NVL+ S ++++I E A ++PDV+ ++D T IK P + Sbjct: 165 LAESRKKHVTLVHKGNVLKVSDGMFKDIFYEEAKKHPDVKADDAHVDAITQWFIKQPEFY 224 Query: 241 DVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIA 300 DV++ NLFGDI+SDE AM+ G +G SA++ ++ + ++EP GS P G + NPI Sbjct: 225 DVIVTENLFGDIISDEAAMVVGGIGTGASANIGDK-YAMFEPIHGSVPKYTGMDKVNPIG 283 Query: 301 QILSLALLLRYSLDADDAACAIERAINRALEEG-IRTGDLARGAAAVSTDEMGDIIARYV 359 I+S+ ++L + +D +A AIE A+ + LEEG I T DL E+G IA V Sbjct: 284 TIMSVKMMLDW-MDYKEAGKAIEDAVYKVLEEGKILTYDL---GGTAKCSEVGKEIASKV 339 >UniRef50_O27441 3-isopropylmalate dehydrogenase n=30 Tax=Archaea RepID=LEU3_METTH Length = 329 Score = 369 bits (948), Expect = e-101, Method: Composition-based stats. Identities = 135/360 (37%), Positives = 195/360 (54%), Gaps = 35/360 (9%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATV 62 K+ IAV+PGDGIG EVM AL +L+ + + + H D G A + G LP T+ Sbjct: 2 KSMKIAVIPGDGIGVEVMEAALHILNTL----DLDLEFIHADAGDACLKRTGTALPEETL 57 Query: 63 EGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 E +A A LFG+ G + ++ LR+ F LF+NLRP K G+ P Sbjct: 58 EAVGEARATLFGAAG-----------ESAADVIVRLRREFDLFANLRPVKSLPGVPCLYP 106 Query: 123 LRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFES 182 D + VRE T +Y G + E A + R RI++ AF+ Sbjct: 107 --------DLDFVIVRENTEDLYVGDEEYTP-----EGAVAKRIITRTASRRISQFAFQY 153 Query: 183 ARKRR-HKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQF 240 A+K KVT++ KANVL+ + ++R+ ++A+EYP +E Y+D M LI P +F Sbjct: 154 AQKEGMQKVTAVHKANVLKKTDGIFRDEFYKVASEYPQMEATDYYVDATAMYLITQPQEF 213 Query: 241 DVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIA 300 ++ +NLFGDILSDE A + G +G+ PSA++ E+ L+EP GSAP IAGKNIANP A Sbjct: 214 QTIVTTNLFGDILSDEAAGLIGGLGLAPSANIGEKN-ALFEPVHGSAPQIAGKNIANPTA 272 Query: 301 QILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYVA 360 IL+ L+L++ L+ A IE+A+ + L EG+ T DL + T EM IAR++ Sbjct: 273 MILTTTLMLKH-LNKKQEAQKIEKALQKTLAEGLVTPDL---GGKLGTMEMAAEIARHLE 328 >UniRef50_A4IK21 Tartrate dehydrogenase n=7 Tax=Bacillaceae RepID=A4IK21_GEOTN Length = 357 Score = 368 bits (945), Expect = e-100, Method: Composition-based stats. Identities = 135/365 (36%), Positives = 197/365 (53%), Gaps = 18/365 (4%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNR-FAMRITTSHYDVGGAAIDNHGQPLPPAT 61 + + IAVLPGDGIGPEVM +ALKVL ++++ + + + HG+ +P Sbjct: 2 REFRIAVLPGDGIGPEVMNEALKVLRILKDKDYTFQFHADMFLWNSEYYLQHGRMMPENG 61 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 ++ + DA+LFG++G P+ PD ++P+RK F + NLRP K +G+ Sbjct: 62 LDILKNYDAILFGAIGDPR----VPDDISVWELIMPIRKRFCQYVNLRPVKKLKGIPEQF 117 Query: 122 PLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFE 181 + + + VRE G Y E A + R ERIAR AF+ Sbjct: 118 IHQERP----INFVIVRENAEGEYSNSGGRIYQGTDQEIAVQNTIITRKGTERIARYAFQ 173 Query: 182 SARKRR-HKVTSIDKAN-VLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQ 239 A+K KV + K+N V+ S LW E++ +A+EYPD++L YID ++ P Sbjct: 174 YAKKHGYQKVINATKSNAVVHSMKLWDEVIEHVASEYPDIQLEKYYIDALAAYFVQRPDT 233 Query: 240 FDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQG--FGLYEPAGGSAPDIAGKNIAN 297 V++ SNLFGDILSD + + G +G+ PSA++N +G ++EP GSAPDIAGK AN Sbjct: 234 LQVIVASNLFGDILSDLGSALVGGLGISPSANINPEGVFPSMFEPVHGSAPDIAGKGKAN 293 Query: 298 PIAQILSLALLLRYSLDADDAACAIERAINRALEEG-IRTGDLARGAAAVSTDEMGDIIA 356 PIAQI S AL+L+ SL +D A I +AI + E G T DL +T EMG+ I Sbjct: 294 PIAQIWSAALMLQ-SLGREDLASIILKAIEKVTEHGEKLTEDL---GGNSTTAEMGEEIV 349 Query: 357 RYVAE 361 R + + Sbjct: 350 RQIVK 354 >UniRef50_Q2RV53 3-isopropylmalate dehydrogenase n=103 Tax=Bacteria RepID=LEU3_RHORT Length = 370 Score = 368 bits (944), Expect = e-100, Method: Composition-based stats. Identities = 172/369 (46%), Positives = 236/369 (63%), Gaps = 10/369 (2%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPA 60 M + I L GDGIGPEVM Q +V+D + VGGAA D G PL Sbjct: 1 MPVSKKILFLAGDGIGPEVMAQVRRVMDWLNQTGRTAFEVEDALVGGAAYDAQGTPLHDD 60 Query: 61 TVEGCEQADAVLFGSVGGPKWE-HLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEA 119 TV ADAVL G+VGGPKW+ LP + +PERG LL LRK +LF+NLRPA ++ L Sbjct: 61 TVALALAADAVLLGAVGGPKWDASLPFELKPERG-LLRLRKDLELFANLRPAMVFDALAE 119 Query: 120 FCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEK-AFDTEVYHRFEIERIARI 178 L+ ++ + G D++ VRELTGG+YFGQP+G E+ +T+VY EI R+A++ Sbjct: 120 ASTLKTELVS-GLDVMIVRELTGGVYFGQPRGISALPNGERRGVNTQVYDTHEIVRVAKV 178 Query: 179 AFESARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPS 238 AF+ A KR ++ S++KANV++S +LWRE V ++ +YP++ L+HMY DN MQL++ P Sbjct: 179 AFDLAGKRGKRLCSVEKANVMESGLLWREEVTKLGADYPEIALSHMYADNCAMQLVRQPK 238 Query: 239 QFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNE-----QGFGLYEPAGGSAPDIAGK 293 QFDV++ NLFGDILSD AM+TGS+GMLPSASL +YEP GSAPDIAG+ Sbjct: 239 QFDVIVTDNLFGDILSDCAAMLTGSLGMLPSASLGAADAAGNRRAMYEPVHGSAPDIAGQ 298 Query: 294 NIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAA-VSTDEMG 352 + ANP+A ILS +++LRYS D + A ++ A+ L +G+RTGD+ + V T MG Sbjct: 299 DKANPLATILSFSMMLRYSFDLAEEADLVDNAVRGVLAKGLRTGDIFQPGKTLVGTTGMG 358 Query: 353 DIIARYVAE 361 D + +A+ Sbjct: 359 DALLAEMAQ 367 >UniRef50_B8N3I6 Tartrate dehydrogenase, putative n=3 Tax=Trichocomaceae RepID=B8N3I6_ASPFN Length = 398 Score = 367 bits (943), Expect = e-100, Method: Composition-based stats. Identities = 118/362 (32%), Positives = 188/362 (51%), Gaps = 17/362 (4%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFA-MRITTSHYDVGGAAIDNHGQPLPPATV 62 Y IA +PGDGIG EV+ A++V++ + I +H G A HG+ + + Sbjct: 46 TYRIASIPGDGIGIEVVDAAIQVVEKLAKTLGTFNIDFTHIPWGTAYYKEHGRYVSEDCL 105 Query: 63 EGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 + + DA LFG+VG P PD G LL LR +L++N+RP + + G + Sbjct: 106 DTLRKFDAGLFGAVGAPD----VPDHISLWGLLLALRGPLQLYANVRPVRTFPGTKCPL- 160 Query: 123 LRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFES 182 + A G D + VRE + G Y GQ +E A + ++ R IERI R AFE Sbjct: 161 ---NTATEGIDWMLVRENSEGEYSGQGGRSHVGQPWEAATEVAMFTRVGIERIMRFAFEV 217 Query: 183 ARKR-RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQF 240 A+ R R +T + K+N ++ +LW ++ E+A ++PDV M +D T++++ P Sbjct: 218 AQSRPRKLLTVVTKSNSMRNGMVLWDQVAAEVAKDFPDVTWDKMLVDAMTVRMVAKPQSI 277 Query: 241 DVLLCSNLFGDILSDECAMITGSMGMLPSASLNE--QGFGLYEPAGGSAPDIAGKNIANP 298 D ++ +NL DILSD A + GS+G+ PS++L+ + ++EP GSA DI GK +ANP Sbjct: 278 DTIVGTNLHMDILSDLAAALAGSIGVAPSSNLDPTRKNPSIFEPVHGSAFDITGKGVANP 337 Query: 299 IAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARY 358 +A S A +L + L +AA + + + GI T DL +T + D + + Sbjct: 338 VATFWSAAEMLSW-LGEKEAAKQLMDCVEKVCAAGILTPDL---GGTSNTQGVVDAVKKE 393 Query: 359 VA 360 + Sbjct: 394 IE 395 >UniRef50_Q2VZV2 3-isopropylmalate dehydrogenase n=35 Tax=Bacteria RepID=LEU3_MAGSA Length = 369 Score = 367 bits (943), Expect = e-100, Method: Composition-based stats. Identities = 180/364 (49%), Positives = 246/364 (67%), Gaps = 10/364 (2%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 + +LPGDGIG EVM Q +++D + + + + +GGAA D HG P P T+E Sbjct: 5 KLLILPGDGIGVEVMAQVRRIIDWMGRKRKIEFEITEGLLGGAAYDVHGTPYPAETLEAA 64 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 ADAVL G+VGGPKW+ LP D++PERG LL +RK LF+NLRPA + + L L+A Sbjct: 65 LAADAVLLGAVGGPKWDDLPFDKKPERG-LLGIRKDMGLFANLRPATVLEALADASTLKA 123 Query: 126 DIAANGFDILCVRELTGGIYFGQPKGREG-SGQYEKAFDTEVYHRFEIERIARIAFESAR 184 ++ + G DI+ +RELTGG+YFGQP+G + K ++T VY EI+RI R+AF+ AR Sbjct: 124 EVVS-GLDIMILRELTGGLYFGQPRGIDTLPDGTRKGYNTLVYTTPEIQRIGRVAFDLAR 182 Query: 185 KRRHKVTSIDKANVLQSSILWREIVNEIATE-YPDVELAHMYIDNATMQLIKDPSQFDVL 243 KR K+ S+DKANVL+ ++LWRE + ++ E +PDVEL HMY+DNA MQL+++P QFDV+ Sbjct: 183 KRNKKLCSVDKANVLECTVLWREEMIKLQKEEFPDVELTHMYVDNAAMQLVRNPKQFDVM 242 Query: 244 LCSNLFGDILSDECAMITGSMGMLPSASLNE-----QGFGLYEPAGGSAPDIAGKNIANP 298 + N+FGDILSD AM+TGS+GMLPSASL E + LYEP GSAPDIAGK++ANP Sbjct: 243 VTENMFGDILSDCAAMLTGSLGMLPSASLGEADAQGKRKALYEPVHGSAPDIAGKDMANP 302 Query: 299 IAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAA-AVSTDEMGDIIAR 357 +A I+S A+ LRYS D A IE A+ L+ G+RT D+ + VST MG+ + R Sbjct: 303 LATIMSFAMCLRYSFDMAAEADLIETAVKNVLKGGLRTADIMQPGKAKVSTTVMGEAVVR 362 Query: 358 YVAE 361 + + Sbjct: 363 ELDK 366 >UniRef50_B3TCK6 Putative isocitrate/isopropylmalate dehydrogenase n=2 Tax=environmental samples RepID=B3TCK6_9ARCH Length = 339 Score = 367 bits (942), Expect = e-100, Method: Composition-based stats. Identities = 118/367 (32%), Positives = 193/367 (52%), Gaps = 36/367 (9%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPA 60 MS Y+I+++ GDGIGPE+ AL +L+A+ + F + + + G A + N G+ LP Sbjct: 1 MSGKYNISLVTGDGIGPEISESALSILEAINDNFPLSLEIKKLEAGDAVLKNTGKALPDE 60 Query: 61 TVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAF 120 T E + +DA L VG + + ++ LR+ L++N+RPAK Y + + Sbjct: 61 TFEAIKNSDACLKAPVG-----------ESAKDVIVYLRRMLDLYANIRPAKSYPNMPSL 109 Query: 121 CPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAF 180 + D++ VRE T +Y G+ + A + +RIA AF Sbjct: 110 --------RDDVDLVIVRENTEDLYTGEEFDI-----GDAAVAFRIISEKASKRIANYAF 156 Query: 181 ESARKRR-HKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPS 238 A KR+ KVT + K+NV++ + L+ +++A ++PDV+ MY+D M LI+ P Sbjct: 157 TIASKRKMKKVTCVHKSNVMKKTDGLFARTCSKVANDFPDVKFEEMYVDACAMNLIRQPQ 216 Query: 239 QFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANP 298 FDV++ +NLFGDILSDE A + G +GM P+A++ + FGL+EP G+A DIAGK IANP Sbjct: 217 LFDVIVTTNLFGDILSDESAQVVGGLGMAPAANIGDN-FGLFEPVHGAAFDIAGKQIANP 275 Query: 299 IAQILSLALLLRYSLDAD------DAACAIERAINRALEEGIRTGDLARGAAAVSTDEMG 352 + ILS+ ++L + + + +E + ++ I+T D+ +T E Sbjct: 276 TSFILSIKMMLDWLGNKHNDQKCIEVGQKLEDVVYDIVKNNIKTKDI---GGDKTTMEFT 332 Query: 353 DIIARYV 359 I + Sbjct: 333 KEIISRL 339 >UniRef50_Q51945 Tartrate dehydrogenase/decarboxylase n=249 Tax=cellular organisms RepID=TTUC_PSEPU Length = 365 Score = 366 bits (941), Expect = e-100, Method: Composition-based stats. Identities = 125/371 (33%), Positives = 188/371 (50%), Gaps = 20/371 (5%) Query: 1 MS-KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDV-GGAAIDNHGQPLP 58 M ++ IA +PGDGIG EV+ + ++VL+A + + + ++ HG+ +P Sbjct: 1 MPAHSFRIAAIPGDGIGLEVLPEGIRVLEAAALKHGLALEFDTFEWASCDYYLQHGKMMP 60 Query: 59 PATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLE 118 E +Q DA+ FG+V W PD G+LL R+ F + N+RP +L+ G+ Sbjct: 61 DDWAEQLKQYDAIYFGAV---DWPDKVPDHISLWGSLLKFRREFDQYVNIRPVRLFPGVP 117 Query: 119 AFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARI 178 A+ D + VRE T G Y + + E ++ R ++RI + Sbjct: 118 CAL---ANRKVGDIDFVVVRENTEGEYSSLGGIMFENTENEIVIQESIFTRRGVDRILKY 174 Query: 179 AFESARKR-RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKD 236 AF+ A KR R VTS K+N + S W + +A YP V +ID + + Sbjct: 175 AFDLAEKRERKHVTSATKSNGMAISMPYWDKRTEAMAAHYPHVSWDKQHIDILCARFVLQ 234 Query: 237 PSQFD-VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQG--FGLYEPAGGSAPDIAGK 293 P +FD V++ SNLFGDILSD G++G+ PSA+LN + L+EP GSAPDI GK Sbjct: 235 PERFDVVVVASNLFGDILSDLGPACAGTIGIAPSANLNPERNFPSLFEPVHGSAPDIFGK 294 Query: 294 NIANPIAQILSLALLLRYSLDADD----AACAIERAINRALEEGIRTGDLARGAAAVSTD 349 NIANPIA I S AL+L + D+ A + AI R + +G T D+ +ST Sbjct: 295 NIANPIAMIWSGALMLEFLGQGDERYQRAHDDMLNAIERVIADGSVTPDM---GGTLSTQ 351 Query: 350 EMGDIIARYVA 360 ++G I+ +A Sbjct: 352 QVGAAISDTLA 362 >UniRef50_Q58991 Homoisocitrate dehydrogenase n=21 Tax=Euryarchaeota RepID=AKSF_METJA Length = 347 Score = 365 bits (938), Expect = 1e-99, Method: Composition-based stats. Identities = 128/363 (35%), Positives = 198/363 (54%), Gaps = 26/363 (7%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 + V+ GDGIG EV+ +A+K+L+ + + G + +G LP T+E Sbjct: 3 KVCVIEGDGIGKEVIPEAIKILNELG-----EFEIIKGEAGLECLKKYGNALPEDTIEKA 57 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 ++AD +LFG++ PK P + + + ++ LRK F L++N+RP + G+ A Sbjct: 58 KEADIILFGAITSPK----PGEVKNYKSPIITLRKMFHLYANVRPINNF-GIGQLIGKIA 112 Query: 126 D---IAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFES 182 D + A DI+ +RE T +Y G+ + + + A V R ERI R AFE Sbjct: 113 DYEFLNAKNIDIVIIRENTEDLYVGRERL-----ENDTAIAERVITRKGSERIIRFAFEY 167 Query: 183 A-RKRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQF 240 A + R KV+ I KANVL+ + L+ E+ NEI Y ++E +D+ M LIK P +F Sbjct: 168 AIKNNRKKVSCIHKANVLRITDGLFLEVFNEIKKHY-NIEADDYLVDSTAMNLIKHPEKF 226 Query: 241 DVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIA 300 DV++ +N+FGDILSDE + + G +G+ PSA++ + L+EP GSAPDIAGK IANP+A Sbjct: 227 DVIVTTNMFGDILSDEASALIGGLGLAPSANIGDD-KALFEPVHGSAPDIAGKGIANPMA 285 Query: 301 QILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYVA 360 ILS+A+L Y + + I A+ L T DL + T ++GD I Y+ Sbjct: 286 SILSIAMLFDY-IGEKEKGDLIREAVKYCLINKKVTPDL---GGDLKTKDVGDEILNYIR 341 Query: 361 EGV 363 + + Sbjct: 342 KKL 344 >UniRef50_A5CDH3 Isocitrate dehydrogenase, NADP-dependent n=7 Tax=Rickettsiales RepID=A5CDH3_ORITB Length = 519 Score = 365 bits (936), Expect = 2e-99, Method: Composition-based stats. Identities = 102/369 (27%), Positives = 175/369 (47%), Gaps = 32/369 (8%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQP-LPP 59 M + + GDGIGPE+M + VL + + ++G + + + Sbjct: 1 MKNVIPVTIAYGDGIGPEIMEAVVYVLKEAA----VPLRLETIEIGEKLYNKYYTYGITE 56 Query: 60 ATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRP-AKLYQGLE 118 T + A+L G V P+ + + LRK L++N+RP + + Sbjct: 57 DTWSQIFRTKALLKGPVTTPQGGG-------YKSLNVTLRKTLGLYANVRPSCSYFPFVN 109 Query: 119 AFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARI 178 P D++ +RE +Y G + ++ R E+I R Sbjct: 110 TSAP--------EIDVVIIRENEEDLYAGIEYHH----TADTYESVKLISRSGSEKIIRF 157 Query: 179 AFESARKR-RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKD 236 AFE A K R ++ K N+++ + ++ + NEIA++Y ++++ H ID + +LI Sbjct: 158 AFEYALKNNRKTISCFSKDNIMKFTDGIFHKTFNEIASQYSNIQVDHYLIDIGSARLISS 217 Query: 237 PSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIA 296 P +FDV++ SNL+GDILSD A I+GS+G+ SA++ + + ++E GSAPDIAG+NIA Sbjct: 218 PQKFDVIVTSNLYGDILSDIAAKISGSIGLAGSANIGKD-YAMFEAVHGSAPDIAGQNIA 276 Query: 297 NPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARG---AAAVSTDEMGD 353 NP + + ++L + L + A IE A+ + +E+GI T D+ + V T E Sbjct: 277 NPSGLLNAAIMMLVH-LGLTEHAAKIENALKKTIEDGIHTADIYNPSISSTKVGTKEFAQ 335 Query: 354 IIARYVAEG 362 I + Sbjct: 336 AIINNLEHK 344 >UniRef50_Q2K2V0 3-isopropylmalate dehydrogenase n=11 Tax=Alphaproteobacteria RepID=LEU3_RHIEC Length = 370 Score = 364 bits (935), Expect = 3e-99, Method: Composition-based stats. Identities = 173/361 (47%), Positives = 228/361 (63%), Gaps = 11/361 (3%) Query: 9 VLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCEQA 68 +LPGDGIGPE M + K++ + T VGG A D HG + A ++ A Sbjct: 8 LLPGDGIGPEAMGEVRKIIAYMNEAMDAGFVTDEGLVGGCAYDAHGAAISEADMQKALAA 67 Query: 69 DAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRADIA 128 DAVLFG+VGGPKW+ +P + +PE G LL LRK +LF+NLRPA Y L + L+ ++ Sbjct: 68 DAVLFGAVGGPKWDSVPYEVRPEAG-LLRLRKDLQLFANLRPAICYPALASASSLKPELV 126 Query: 129 ANGFDILCVRELTGGIYFGQPKGREGSGQ-YEKAFDTEVYHRFEIERIARIAFESARKRR 187 G DIL +RELTGG+YFG+PK G ++ DT+VY +EIERIA +AFE AR R+ Sbjct: 127 -EGLDILIIRELTGGVYFGEPKEIIDLGNGQKRGIDTQVYDTYEIERIAGVAFEMARTRQ 185 Query: 188 HKVTSIDKANVLQSSILWREIVNEIAT-EYPDVELAHMYIDNATMQLIKDPSQFDVLLCS 246 ++V S++K NV++S +LW ++V E +Y DV+L HM D MQL++ P QFDV++ Sbjct: 186 NRVCSMEKRNVMKSGVLWNQVVTETHKAKYSDVQLEHMLADAGGMQLVRQPKQFDVIVTD 245 Query: 247 NLFGDILSDECAMITGSMGMLPSASLNE------QGFGLYEPAGGSAPDIAGKNIANPIA 300 NLFGD+LSD AM+TGS+GMLPSASL + LYEP GSAPDIAGK IANPIA Sbjct: 246 NLFGDMLSDVAAMLTGSLGMLPSASLGAPDGKTGKRKALYEPVHGSAPDIAGKGIANPIA 305 Query: 301 QILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGA-AAVSTDEMGDIIARYV 359 I S A+ LRYS + A +E+AI L++GIRTGD+ V T EMG+ I Sbjct: 306 MIASFAMCLRYSFNMVKEADDLEKAIANVLDKGIRTGDIMADGCRQVGTVEMGEAILAEF 365 Query: 360 A 360 Sbjct: 366 K 366 >UniRef50_Q5SIJ1 Homoisocitrate dehydrogenase n=13 Tax=cellular organisms RepID=Q5SIJ1_THET8 Length = 334 Score = 363 bits (933), Expect = 4e-99, Method: Composition-based stats. Identities = 121/359 (33%), Positives = 179/359 (49%), Gaps = 30/359 (8%) Query: 5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEG 64 Y I ++ GDGIG EV+ A +VL+A + + + G + G +P TVE Sbjct: 3 YRICLIEGDGIGHEVIPAARRVLEA----TGLPLEFVEAEAGWETFERRGTSVPEETVEK 58 Query: 65 CEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 A LFG+ P GA+ LR+ L++N+RPAK Sbjct: 59 ILSCHATLFGAATSP-----TRKVPGFFGAIRYLRRRLDLYANVRPAKSRP--------- 104 Query: 125 ADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESAR 184 + G D++ VRE T G+Y Q + + A V + ERI R A A Sbjct: 105 VPGSRPGVDLVIVRENTEGLYVEQERRY-----LDVAIADAVISKKASERIGRAALRIAE 159 Query: 185 KR-RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDV 242 R R + KANVL + L+ + V E+A ++P V + + +DN MQL+ P +FDV Sbjct: 160 GRPRKTLHIAHKANVLPLTQGLFLDTVKEVAKDFPLVNVQDIIVDNCAMQLVMRPERFDV 219 Query: 243 LLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQI 302 ++ +NL GDILSD A + G +G+ PS ++ + ++EP GSAPDIAGK IANP A I Sbjct: 220 IVTTNLLGDILSDLAAGLVGGLGLAPSGNIGDT-TAVFEPVHGSAPDIAGKGIANPTAAI 278 Query: 303 LSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYVAE 361 LS A++L Y L +AA +E+A++ LE G RT DL +T+ + + + Sbjct: 279 LSAAMMLDY-LGEKEAAKRVEKAVDLVLERGPRTPDL---GGDATTEAFTEAVVEALKS 333 >UniRef50_P70787 Probable tartrate dehydrogenase/decarboxylase ttuC n=117 Tax=cellular organisms RepID=TTUC2_AGRVI Length = 364 Score = 363 bits (932), Expect = 6e-99, Method: Composition-based stats. Identities = 117/363 (32%), Positives = 184/363 (50%), Gaps = 16/363 (4%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFA-MRITTSHYDVGGAAIDNHGQPLPPAT 61 + Y IA +P DGIGPEV+ L+VL+A+ R I T +D G +G +P Sbjct: 2 REYKIAAIPADGIGPEVIAAGLQVLEALEKRSGDFSIHTETFDWGSDYYKKNGVMMPADG 61 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 +E ++ DA+ FG+VG P PD G LP+ + F ++N+RP K+ G+ Sbjct: 62 LEQLKKFDAIFFGAVGAPD----VPDHITLWGLRLPICQGFDQYANVRPTKVLPGIT--- 114 Query: 122 PLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFE 181 P + D + VRE + G Y G E + ++ R + RI R AF+ Sbjct: 115 PPLRNCGPGDLDWVIVRENSEGEYSGHGGRAHKGLPEEVGTEVAIFTRVGVTRIMRYAFK 174 Query: 182 SARKR-RHKVTSIDKANVLQS-SILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQ 239 A+ R R +T + K+N + ++W EI E++ E+PDV M +D T+++ P Sbjct: 175 LAQARPRKLLTVVTKSNAQRHGMVMWDEIAAEVSKEFPDVTWDKMLVDAMTVRMTLKPQS 234 Query: 240 FDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQG--FGLYEPAGGSAPDIAGKNIAN 297 D ++ +NL DILSD + GS+G+ P+A+++ + ++EP GSA DI GK IAN Sbjct: 235 LDTIVATNLHADILSDLAGALAGSLGVAPTANIDPERRFPSMFEPIHGSAFDITGKGIAN 294 Query: 298 PIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIAR 357 P+A + A +L + L DAA + A+ R E GI T D+ T ++ D + Sbjct: 295 PVATFWTAAQMLEH-LGEKDAATRLMSAVERVTEAGILTPDV---GGTADTQQVTDAVCE 350 Query: 358 YVA 360 +A Sbjct: 351 AIA 353 >UniRef50_P42958 Probable tartrate dehydrogenase/decarboxylase n=8 Tax=Bacteria RepID=TTUC_BACSU Length = 354 Score = 363 bits (932), Expect = 6e-99, Method: Composition-based stats. Identities = 122/363 (33%), Positives = 185/363 (50%), Gaps = 17/363 (4%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLD-AVRNRFAMRITTSHYDVGGAAIDNHGQPLPPAT 61 K + IA +PGDG+G EV+ A KVL A + + + + HG+ +P Sbjct: 4 KQFEIAAIPGDGVGKEVVAAAEKVLHTAAEVHGGLSFSFTAFPWSCDYYLEHGKMMPEDG 63 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 + Q +AV G+VG PK L PD G LL +R+ +L N+RPAK G+ + Sbjct: 64 IHTLTQFEAVFLGAVGNPK---LVPDHISLWGLLLKIRRELELSINMRPAKQMAGITSPL 120 Query: 122 PLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFE 181 + N FD + +RE + G Y G E A V+ R ER+ R AFE Sbjct: 121 -----LHPNDFDFVVIRENSEGEYSEVGGRIHR-GDDEIAIQNAVFTRKATERVMRFAFE 174 Query: 182 SARKRRHKVTSIDKAN-VLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQF 240 A+KRR VTS K+N + + W E+ + A +Y +E + +ID + P F Sbjct: 175 LAKKRRSHVTSATKSNGIYHAMPFWDEVFQQTAADYSGIETSSQHIDALAAFFVTRPETF 234 Query: 241 DVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQG--FGLYEPAGGSAPDIAGKNIANP 298 DV++ SNLFGDIL+D + + GS+G+ PSA++N G ++EP GSAPDIAG+ +ANP Sbjct: 235 DVIVASNLFGDILTDISSSLMGSIGIAPSANINPSGKYPSMFEPVHGSAPDIAGQGLANP 294 Query: 299 IAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARY 358 I QI + L+L + ++ I + + +GI+T D+ +T E+ D I Sbjct: 295 IGQIWTAKLMLDH-FGEEELGAKILDVMEQVTADGIKTRDI---GGQSTTAEVTDEICSR 350 Query: 359 VAE 361 + + Sbjct: 351 LRK 353 >UniRef50_Q6W109 Tartrate dehydrogenase n=13 Tax=Bacteria RepID=Q6W109_RHISN Length = 347 Score = 361 bits (928), Expect = 2e-98, Method: Composition-based stats. Identities = 135/360 (37%), Positives = 190/360 (52%), Gaps = 18/360 (5%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATV 62 K+Y IA++PGDGIG +V A +VL V +T + + A G +PP + Sbjct: 2 KSYSIALIPGDGIGQDVTDAAWQVLSTVARHSGFTLTATPFPWSCAFYKETGAMMPPDGI 61 Query: 63 EGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 E + DA+L G+VG W PD G LLP+RK F ++N+RP +L G+ Sbjct: 62 ETLRRFDAILLGAVG---WPAEVPDSVSLHGLLLPIRKAFVQYANIRPHRLLSGV----- 113 Query: 123 LRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFES 182 + + A GFDILC+RE T G Y G E A +T ++ R +ERI R F+ Sbjct: 114 -KGPLKAEGFDILCIRENTEGEYSGAGGRVHQGTADEVAVETSIFTRTGVERILRFGFDQ 172 Query: 183 ARKRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFD 241 AR+RR K+ S+ K+N + S +LW EI E+A EYPDVE+ +ID +++ P D Sbjct: 173 ARQRRRKLASVTKSNAQKYSMVLWDEITRELAAEYPDVEVTSYHIDAMAARMVMAPESLD 232 Query: 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQG--FGLYEPAGGSAPDIAGKNIANPI 299 V++ SNLFGDIL+D A I G +G SA++N ++EP GSAPDIA IANPI Sbjct: 233 VVVASNLFGDILTDLGAAIQGGLGFAASANINPDRSAPSMFEPVHGSAPDIAHLGIANPI 292 Query: 300 AQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYV 359 A I S A++L + A A IE A+ R GI T T+ + + + Sbjct: 293 AAIWSGAMMLDHLGQARAARKVIE-ALERTTARGIGTVP-----GKNRTETITAAVLAAL 346 >UniRef50_Q5LAB4 3-isopropylmalate dehydrogenase n=58 Tax=Bacteria RepID=LEU3_BACFN Length = 353 Score = 361 bits (926), Expect = 3e-98, Method: Composition-based stats. Identities = 158/358 (44%), Positives = 225/358 (62%), Gaps = 9/358 (2%) Query: 5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEG 64 + IAVL GDGIGPE+ Q ++V+ AV +F ++ + G AID G P P T Sbjct: 3 FKIAVLAGDGIGPEISVQGVEVMSAVCEKFGHKVNYEYAICGADAIDKVGDPFPEETYRV 62 Query: 65 CEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 C+ ADAVLF +VG PK+++ P + LL +RK LF+N+RP + ++ L PLR Sbjct: 63 CKNADAVLFSAVGDPKFDNDPTAKVRPEQGLLAMRKKLGLFANIRPVQTFKCLVHKSPLR 122 Query: 125 ADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESAR 184 A++ G D LC+RELTGG+YFG+ +KA+DT +Y R EIERI ++ FE A Sbjct: 123 AELV-EGADFLCIRELTGGMYFGEK-----YQDNDKAYDTNMYTRPEIERILKVGFEYAM 176 Query: 185 KRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLL 244 KRR +T +DKANVL SS LWR+I E+A +YP+V +M++DNA M++I++P FDV++ Sbjct: 177 KRRKHLTVVDKANVLASSRLWRQIAQEMAPQYPEVTTDYMFVDNAAMKMIQEPKFFDVMV 236 Query: 245 CSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILS 304 N FGDIL+DE ++I+GSMG+LPSAS E ++EP GS P G NIANP+AQILS Sbjct: 237 TENTFGDILTDEGSVISGSMGLLPSASTGESTP-VFEPIHGSWPQAKGLNIANPLAQILS 295 Query: 305 LALLLRYSLDADDAACAIERAINRALEEGIRTGDL-ARGAAAVSTDEMGDIIARYVAE 361 +A+L Y D I +A++ +L+ +RT ++ G T E+G I Y+ + Sbjct: 296 VAMLFEY-FDCKAEGALIRKAVDASLDANVRTPEIQVEGGEKFGTKEVGAWIVDYIRK 352 >UniRef50_B9KYU3 Isocitrate dehydrogenase (NADP) n=3 Tax=Bacteria RepID=B9KYU3_THERP Length = 496 Score = 359 bits (922), Expect = 8e-98, Method: Composition-based stats. Identities = 117/360 (32%), Positives = 180/360 (50%), Gaps = 27/360 (7%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNH-GQPLPPATVEGC 65 + ++PGDGIGPE++ A ++++AV I G + +P T+E Sbjct: 23 VTLIPGDGIGPEIVESACRLIEAV----GAPIEWEVRRAGASVFREGIASGVPDDTIESI 78 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 ++ VL G + P E+ A + LRK F+ F+N+RP + + Sbjct: 79 KRTRVVLKGPLETPVGYG-------EKSANVTLRKLFEAFANVRPVRELPSVPTPY---- 127 Query: 126 DIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESAR- 184 D++ VRE +Y + RE G ++ E+I R AFE AR Sbjct: 128 --RGRNIDLVVVRENIEDLYAAI-EYRETPG---VTIAHKLISYKGSEKIIRFAFELARA 181 Query: 185 KRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVL 243 + R KVT K+N+L+ + ++ I EIA+EYPD+E H+ IDN QL+K P QF+V+ Sbjct: 182 EGRKKVTCATKSNILKLTEGWFQHIFEEIASEYPDIEANHLIIDNCAHQLVKAPEQFEVI 241 Query: 244 LCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQIL 303 + +NL GDI+SD + + G +G S + + ++EP G+AP AGKN+ NP A IL Sbjct: 242 VTTNLNGDIISDLASGLVGGLGFAASGNYGHE-VAIFEPVHGTAPKYAGKNVINPTAMIL 300 Query: 304 SLALLLRYSLDADDAACAIERAINRALEEGI-RTGDLARGAAAVSTDEMGDIIARYVAEG 362 + ++LRY +D + A IE+A+ LEEG T D+ AVST D I + Sbjct: 301 TAVMMLRY-IDEFETAETIEQALIVTLEEGKALTRDVVGDERAVSTTAFTDAIIANLGRR 359 >UniRef50_A9IDG2 Tartrate dehydrogenase n=5 Tax=cellular organisms RepID=A9IDG2_BORPD Length = 363 Score = 359 bits (922), Expect = 8e-98, Method: Composition-based stats. Identities = 111/365 (30%), Positives = 178/365 (48%), Gaps = 17/365 (4%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFA-MRITTSHYDVGGAAIDNHGQPLPPAT 61 K Y IA +PGDGIG EV+ + + + +D GG HG +P Sbjct: 2 KTYRIATIPGDGIGKEVIPAGRQAMQVLAETDGSFTFEFQDFDWGGDYYRRHGVMMPADG 61 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 +E DA+LFGS G P D G L + + ++N+RP +L G++ Sbjct: 62 LEPLRDKDAILFGSAGDPDIA----DHITLWGLRLKICQGLDQYANVRPTRLLPGIDGPL 117 Query: 122 PLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFE 181 A D + VRE + G Y G E A D + R +ERI R AF Sbjct: 118 ---KRCTAEQLDWVIVRENSEGEYSGVGGRVHQGLPIEAATDVSMMTRAGVERILRYAFR 174 Query: 182 SARKR-RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQ 239 A+ R R ++T + K+N + + ++W EI EI+ E+PDV +D AT +++ P+ Sbjct: 175 LAQSRPRKQLTVVTKSNAQRHAMVMWDEIALEISREFPDVRWDKELVDAATARMVNRPAS 234 Query: 240 FDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQ--GFGLYEPAGGSAPDIAGKNIAN 297 D ++ +NL DILSD A + GS+G+ P+ +++ + G ++EP GSA DI GK +AN Sbjct: 235 LDTIVATNLHADILSDLAAALAGSLGIAPTGNIDPERRGPSMFEPIHGSAFDIMGKGLAN 294 Query: 298 PIAQILSLALLLRYSLDADDAACAIERAINRALEE-GIRTGDLARGAAAVSTDEMGDIIA 356 PI S+ +LL + L AA + RA+ + + T DL +T+++ + Sbjct: 295 PIGTFWSVVMLLEH-LGEHQAAARMMRAVESVTADQALHTRDL---GGTATTEQVTQAVC 350 Query: 357 RYVAE 361 +++ + Sbjct: 351 QHLRQ 355 >UniRef50_UPI000150AB37 dehydrogenase, isocitrate/isopropylmalate family protein n=1 Tax=Tetrahymena thermophila RepID=UPI000150AB37 Length = 636 Score = 358 bits (919), Expect = 2e-97, Method: Composition-based stats. Identities = 105/361 (29%), Positives = 172/361 (47%), Gaps = 31/361 (8%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPAT 61 +N+ + + PG GIGPE+ + A + + I H+++ I+ G + + Sbjct: 302 KQNHKVVLFPGHGIGPEISQAVCDIFAAAK----VPIDWEHHEIYTKPINEAGDLIKEES 357 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 + L G P + R + +RK LF+N+RP + G++ Sbjct: 358 LNAVINYKWGLKGPFATPIG-------KGYRSLNVTMRKKLNLFANVRPCRSLAGVKTPY 410 Query: 122 PLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFE 181 D++ +RE T G Y G E + + ++ + E IAR AFE Sbjct: 411 S--------NVDLVTIRENTEGEYSG----LEHAVVPGVVENLKIISQPACENIARYAFE 458 Query: 182 SARKR-RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQ 239 ARK R KV + KA V++ L+ +I++EYP++E ID M+L K+P Sbjct: 459 FARKNNRKKVVACHKAGVMKKGDGLFINTCKKISSEYPEIEYTEEQIDTVCMKLSKNPEV 518 Query: 240 FDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPI 299 FDV++ NL+GDI+SD CA + G +G+ S +++ +YE G+APDIAG N ANP Sbjct: 519 FDVMVMPNLYGDIVSDLCAGLIGGLGLTASGNISHTC-AVYEAVHGTAPDIAGLNKANPT 577 Query: 300 AQILSLALLLRYSLDADDAACAIERAINRALEEGI-RTGDLARGAAAVSTDEMGDIIARY 358 A +LS ++L+ ++ AIE A+ + L EG TGDL +T + + + Sbjct: 578 ALLLSGVMMLK-AMGLQKEGFAIEEAVIKTLSEGKFLTGDL---GGKATTTDYTKAVIGH 633 Query: 359 V 359 + Sbjct: 634 I 634 >UniRef50_Q0D0R7 Isocitrate dehydrogenase subunit 2, mitochondrial n=17 Tax=Dikarya RepID=Q0D0R7_ASPTN Length = 385 Score = 358 bits (918), Expect = 2e-97, Method: Composition-based stats. Identities = 106/361 (29%), Positives = 172/361 (47%), Gaps = 34/361 (9%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 Y + ++ GDGIGPE+ + A I DV + + +P +E Sbjct: 54 KYTVTLIEGDGIGPEISQSVKDIFSAANA----PIKWEPVDVTPI-LKDGKTAIPDDAIE 108 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 + L G + P + L LR+ F LF+N+RP + G + Sbjct: 109 SVRRNYVALKGPLATPVG-------KGHVSLNLTLRRTFNLFANVRPCRSIAGYKTPY-- 159 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 + D + +RE T G Y G E ++ + ER+ R AF+ A Sbjct: 160 ------DNVDTVLIRENTEGEYSG----IEHVVVDGVVQSIKLITKEASERVLRFAFQYA 209 Query: 184 RK-RRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFD 241 R + KV + KA +++ S L+ EIA ++PDVE +DN+ ++++ DP+ ++ Sbjct: 210 RSINKKKVRVVHKATIMKMSDGLFLNTAREIAKDFPDVEFDAELLDNSCLKIVTDPTPYN 269 Query: 242 --VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPI 299 VL+ NL+GDILSD CA + G +G+ PS ++ ++ ++E GSAPDIAGK +ANP Sbjct: 270 DKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDEC-SIFEAVHGSAPDIAGKGLANPT 328 Query: 300 AQILSLALLLRYSLDADDAACAIERAINRALEEGI-RTGDLARGAAAVSTDEMGDIIARY 358 A +LS ++L++ + + A I++AI L EG TGDL T E + I + Sbjct: 329 ALLLSSIMMLQH-MGLHEHAGRIQKAIFDTLAEGKALTGDL---GGKAKTSEYAEAIMKK 384 Query: 359 V 359 + Sbjct: 385 L 385 >UniRef50_P33197 Isocitrate dehydrogenase [NADP] n=10 Tax=Bacteria RepID=IDH_THET8 Length = 496 Score = 357 bits (917), Expect = 3e-97, Method: Composition-based stats. Identities = 116/359 (32%), Positives = 180/359 (50%), Gaps = 27/359 (7%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNH-GQPLPPATVEGC 65 I V+PGDGIGPE + LKVL+A + + + G + +P T+E Sbjct: 22 ITVIPGDGIGPECVEATLKVLEAAKA----PLAYEVREAGASVFRRGIASGVPQETIESI 77 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 + VL G + P E+ A + LRK F+ ++N+RP + + + Sbjct: 78 RKTRVVLKGPLETPVGYG-------EKSANVTLRKLFETYANVRPVREFPNVPTPY---- 126 Query: 126 DIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESAR- 184 A G D++ VRE +Y G E A ++ E+I R AFE AR Sbjct: 127 --AGRGIDLVVVRENVEDLYAG----IEHMQTPSVAQTLKLISWKGSEKIVRFAFELARA 180 Query: 185 KRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVL 243 + R KV K+N+++ + + ++A EYPD+E H+ +DNA QL+K P QF+V+ Sbjct: 181 EGRKKVHCATKSNIMKLAEGTLKRAFEQVAQEYPDIEAVHIIVDNAAHQLVKRPEQFEVI 240 Query: 244 LCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQIL 303 + +N+ GDILSD + + G +G PSA++ + ++E GSAP AGKN+ NP A +L Sbjct: 241 VTTNMNGDILSDLTSGLIGGLGFAPSANIGNE-VAIFEAVHGSAPKYAGKNVINPTAVLL 299 Query: 304 SLALLLRYSLDADDAACAIERAINRALEEG-IRTGDLARGAAAVSTDEMGDIIARYVAE 361 S ++LRY L+ A IE A+ LEEG + TGD+ T E + I + + + Sbjct: 300 SAVMMLRY-LEEFATADLIENALLYTLEEGRVLTGDVVGYDRGAKTTEYTEAIIQNLGK 357 >UniRef50_B1MJY2 Tartrate dehydrogenase n=5 Tax=Bacteria RepID=B1MJY2_MYCA9 Length = 350 Score = 354 bits (909), Expect = 2e-96, Method: Composition-based stats. Identities = 132/362 (36%), Positives = 189/362 (52%), Gaps = 18/362 (4%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPA 60 MS +A +PGDGIG +V +A+KV+D+ RI + +D G +PP Sbjct: 1 MSDRMRVATIPGDGIGVDVTREAVKVMDSA---TGGRIEWTEFDYSCERYAKTGAMMPPD 57 Query: 61 TVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAF 120 DA+L G+VG P PD G L+PLR+ F + NLRP +L G+ + Sbjct: 58 APTTLAGFDAILLGAVGYPG----VPDDVSLWGLLIPLRRAFNQYVNLRPVRLLPGIASP 113 Query: 121 CPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAF 180 A ++ ++ VRE T G Y Q E A V+ R ERI R AF Sbjct: 114 L---AGVSDEALSMVIVRENTEGEYSPIGGVHNRGNQNEFALQESVFTRIGCERIIRYAF 170 Query: 181 ESARKRRHKVTSIDKAN-VLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQ 239 E A +V S K+N ++ S W I NEIA EYP M++D +++ DP+ Sbjct: 171 ELAASAGFRVCSATKSNGIIHSMPYWDSIFNEIAAEYPQTPSVSMHVDALAARMVSDPAS 230 Query: 240 FDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFG--LYEPAGGSAPDIAGKNIAN 297 DV++ SNLFGDILSD A ITG +G+ S ++N + ++E GSAPDIAG+ IAN Sbjct: 231 LDVIVASNLFGDILSDLAAAITGGLGLAASGNINPERTAISMFESVHGSAPDIAGQGIAN 290 Query: 298 PIAQILSLALLLRYSLDADDAACAIERAINRALEEG-IRTGDLARGAAAVSTDEMGDIIA 356 P+AQIL+ A+LL + L+ A I A+++ L +G +RT DL +T+++G IA Sbjct: 291 PVAQILAGAMLLDH-LNEPATANKIRLAVDQVLSDGRVRTPDL---GGTATTEQLGTAIA 346 Query: 357 RY 358 Sbjct: 347 EA 348 >UniRef50_C1XGT6 Homoisocitrate dehydrogenase n=1 Tax=Meiothermus ruber DSM 1279 RepID=C1XGT6_MEIRU Length = 335 Score = 353 bits (907), Expect = 4e-96, Method: Composition-based stats. Identities = 124/361 (34%), Positives = 184/361 (50%), Gaps = 28/361 (7%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPA 60 MSK Y I ++ GDGIG EV+ A VL+A ++ G + G +P A Sbjct: 1 MSKTYKICLIEGDGIGHEVIPAARLVLEA----TGLKFEFVEAQAGWETFERIGTSVPEA 56 Query: 61 TVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAF 120 T+E DA LFG+ P GA+ +R+ LF+N+RPAK + Sbjct: 57 TLEAVTHTDATLFGAATSP-----TKKVPGFFGAIRYMRRKLDLFANVRPAKHHP----- 106 Query: 121 CPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAF 180 + G D++ VRE T G+Y Q + + E A V R RI A Sbjct: 107 ----VPGSRPGVDLIVVRENTEGLYVEQERSY---LEGEIAIADTVITRKASARIGEYAA 159 Query: 181 ESARKR-RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPS 238 A R R ++ KANVL + L+ V A +P+V+ + IDN MQL+++P Sbjct: 160 RLAASRPRKQLHVAHKANVLPMTQGLFMNTVLAEAARFPEVKTQDIIIDNCAMQLVRNPE 219 Query: 239 QFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANP 298 +FDV++ +NLFGDI+SD A + G +G+ S ++ + ++EP GSAPDIAGK IANP Sbjct: 220 RFDVIVTTNLFGDIISDLTAGLVGGLGIAASGNIGIK-HAVFEPVHGSAPDIAGKGIANP 278 Query: 299 IAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARY 358 A ILS ++L + L +AA +E A+++ L+EG RT DL +T + + +AR Sbjct: 279 AATILSGVMMLDH-LGEHEAARRVEAAVDKVLQEGPRTPDL---GGNATTLQFAEAVARS 334 Query: 359 V 359 + Sbjct: 335 L 335 >UniRef50_Q1ARE1 3-isopropylmalate dehydrogenase n=2 Tax=Bacteria RepID=Q1ARE1_RUBXD Length = 355 Score = 353 bits (907), Expect = 5e-96, Method: Composition-based stats. Identities = 171/346 (49%), Positives = 223/346 (64%), Gaps = 10/346 (2%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPA 60 MS+ + + +LPGDGIGPEV+ A +V DA RF + + +G AAI G P+ Sbjct: 1 MSQRFRVLLLPGDGIGPEVVAAARRVADAAAARFGLTLEYEERRIGAAAIREEGAPVSKE 60 Query: 61 TVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAF 120 T+ +ADAVL G+VG P+++ + +PE G LL LR+ F+NLRP L Sbjct: 61 TLRRAGEADAVLLGAVGDPEFDG--GEVRPEAG-LLALRRELGTFANLRPVAAIPALSGS 117 Query: 121 CPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAF 180 PLR + A G D+L VRELTGG YFG+ + E E+A D VY R E+ER+AR+AF Sbjct: 118 SPLRPGV-AEGVDLLIVRELTGGAYFGEKEEGE-----ERASDLSVYTRGEVERVARVAF 171 Query: 181 ESARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQF 240 E+AR RR +V S+DKANVL +S LWR +V E+A +YPDV L H+ +D A M L+ DP +F Sbjct: 172 EAARGRRGRVASVDKANVLATSRLWRRVVGEVARDYPDVALEHVLVDAAAMHLVTDPGRF 231 Query: 241 DVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQG-FGLYEPAGGSAPDIAGKNIANPI 299 DV+L NLFGDILSDE A++ GSMGMLPSASL E G G++EP GSAPDIAGK +ANP Sbjct: 232 DVILTENLFGDILSDEAAVLPGSMGMLPSASLGEPGSPGIFEPVHGSAPDIAGKGVANPY 291 Query: 300 AQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAA 345 A ILS A++ R+ L +AA AIER + A+ G T DL + Sbjct: 292 AAILSAAMMFRHGLGRPEAAEAIERGVEAAVAAGCLTPDLGGSSGT 337 >UniRef50_C3MI61 3-isopropylmalate dehydrogenase n=13 Tax=Proteobacteria RepID=C3MI61_RHISN Length = 371 Score = 353 bits (907), Expect = 5e-96, Method: Composition-based stats. Identities = 124/370 (33%), Positives = 189/370 (51%), Gaps = 23/370 (6%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMR-ITTSHYDVGGAAIDNHGQPLPPA 60 + IAVLPGDGIG EVM L++++A + ++ G G LP + Sbjct: 5 NDTLTIAVLPGDGIGREVMPACLELVNAATTMAGAPALAFQTHNAGAQYYAESGDALPAS 64 Query: 61 TVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAF 120 T++ C ++DA+LFG++G P + E L LR LF+ +RP + + GL Sbjct: 65 TLDACRKSDAILFGAMGWPD---IRFPDGTEIIPQLDLRMELGLFAGVRPIRWFPGLPRV 121 Query: 121 CPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAF 180 D A D + VRE T G+++ + +G E+A+DT R +R+ AF Sbjct: 122 LT---DPRAEQIDFVLVREQTEGLFYARGRGEIR--NDEEAYDTMQITRSGTQRVTEFAF 176 Query: 181 ESARKRRHK-----VTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIK 235 + AR+R+ + VT +DKANV QS +R++ +E+A + D+ H Y+D + ++K Sbjct: 177 DIARQRKRRGKPGNVTCVDKANVFQSMAFFRKVFDEVADRHSDLTKDHAYVDALALNMVK 236 Query: 236 DPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNI 295 P FDVL+ N+FGDILSD A + G MGM PSA + ++ GL++PA G+APDIAGK Sbjct: 237 KPWTFDVLVTENMFGDILSDLAAGLIGGMGMAPSADIGDK-HGLFQPAHGTAPDIAGKGC 295 Query: 296 ANPIAQILSLALLLRYSLD------ADDAACAIERAINRALEEGIRTGDLARGAAAVSTD 349 ANP A LS A++L + DAA +E A+ L + + Sbjct: 296 ANPSAMFLSAAMMLDWLAAKFGQPTLADAARLMEGAVEHTLSTKLAIP--MEYGGNANCA 353 Query: 350 EMGDIIARYV 359 EM + + Sbjct: 354 EMTRSVISSL 363 >UniRef50_Q2JYV7 Probable tartrate dehydrogenase protein n=7 Tax=Rhizobium etli RepID=Q2JYV7_RHIEC Length = 347 Score = 351 bits (900), Expect = 3e-95, Method: Composition-based stats. Identities = 128/360 (35%), Positives = 182/360 (50%), Gaps = 18/360 (5%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATV 62 K Y IA+LPGDGIG +V A VL+ + + Y +G +P + Sbjct: 2 KTYRIALLPGDGIGRDVTDAAWAVLEKTAGSGGFSLEATRYPWSCDYYLENGSMMPADGI 61 Query: 63 EGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 E + DA+L G+VG W PD G LLP+RK F ++N+RP +L G++ Sbjct: 62 ETLKSFDAILLGAVG---WPRKVPDSVSLHGLLLPIRKAFVQYANIRPHRLLPGVQGP-- 116 Query: 123 LRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFES 182 + ++GFDILC+RE T G Y G E A +T ++ R +ERI R FE Sbjct: 117 ----LRSDGFDILCIRENTEGEYSGAGGRIHQGADNEVAIETAIFTRKGVERILRFGFEQ 172 Query: 183 ARKRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFD 241 AR RR K+ S+ K+N + S + W EI + ++ EYPDVE+ +ID +++ P D Sbjct: 173 ARARRGKLASVTKSNAQKYSMVFWDEITHGLSAEYPDVEVTSYHIDAMAARMVMAPESLD 232 Query: 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQG--FGLYEPAGGSAPDIAGKNIANPI 299 V+ SNLFGDIL+D A I G +G SA++N ++EP GSAPDIA IANPI Sbjct: 233 VVAASNLFGDILTDLGAAIQGGLGFAASANINPDRSAPSMFEPVHGSAPDIAHLGIANPI 292 Query: 300 AQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYV 359 A I S A++L + L AA + AI G+ TD + + + Sbjct: 293 AAIWSGAMMLEH-LGETAAAEKVMDAIETTTARGV-----GAIPGKDRTDAITASVLSAL 346 >UniRef50_P04173 3-isopropylmalate dehydrogenase n=61 Tax=Fungi/Metazoa group RepID=LEU3_YEAST Length = 364 Score = 349 bits (896), Expect = 1e-94, Method: Composition-based stats. Identities = 166/372 (44%), Positives = 231/372 (62%), Gaps = 22/372 (5%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVR-NRFAMRITTSHYDVGGAAIDNHGQPLPP 59 MS I VLPGD +G E+ +A+KVL A+ R ++ ++ +GGAAID G PLP Sbjct: 1 MSAPKKIVVLPGDHVGQEITAEAIKVLKAISDVRSNVKFDFENHLIGGAAIDATGVPLPD 60 Query: 60 ATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLY-QGLE 118 +E ++ADAVL G+VGGPKW +PE+G LL +RK +L++NLRP L Sbjct: 61 EALEASKKADAVLLGAVGGPKWG--TGSVRPEQG-LLKIRKELQLYANLRPCNFASDSLL 117 Query: 119 AFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARI 178 P++ A G D + VREL GGIYFG+ K +G G A+D+E Y E++RI R+ Sbjct: 118 DLSPIKPQF-AKGTDFVVVRELVGGIYFGKRKEDDGDG---VAWDSEQYTVPEVQRITRM 173 Query: 179 AFESARKRRHK--VTSIDKANVLQSSILWREIVNE-IATEYPDVELAHMYIDNATMQLIK 235 A A + + S+DKANVL SS LWR+ V E I E+P +++ H ID+A M L+K Sbjct: 174 AAFMALQHEPPLPIWSLDKANVLASSRLWRKTVEETIKNEFPTLKVQHQLIDSAAMILVK 233 Query: 236 DPSQFD-VLLCSNLFGDILSDECAMITGSMGMLPSASLN-----EQGFGLYEPAGGSAPD 289 +P+ + +++ SN+FGDI+SDE ++I GS+G+LPSASL FGLYEP GSAPD Sbjct: 234 NPTHLNGIIITSNMFGDIISDEASVIPGSLGLLPSASLASLPDKNTAFGLYEPCHGSAPD 293 Query: 290 IAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTD 349 + KN NPIA ILS A++L+ SL+ + AIE A+ + L+ GIRTGDL + ST Sbjct: 294 LP-KNKVNPIATILSAAMMLKLSLNLPEEGKAIEDAVKKVLDAGIRTGDL---GGSNSTT 349 Query: 350 EMGDIIARYVAE 361 E+GD +A V + Sbjct: 350 EVGDAVAEEVKK 361 >UniRef50_UPI0001C310FF Tartrate decarboxylase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C310FF Length = 370 Score = 349 bits (895), Expect = 1e-94, Method: Composition-based stats. Identities = 126/354 (35%), Positives = 188/354 (53%), Gaps = 18/354 (5%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 ++ +LPGDG+GPEVM +A K LDA+ + I + G A HG +P ++ Sbjct: 2 NVVLLPGDGVGPEVMAEARKALDAL----ELGIAWTDVPWGSAWWAEHGTMMPADAIDVL 57 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 DA+L G+VG P PD + G +L +R+ L+ N+RPA+L +G+ A Sbjct: 58 RGHDAILMGAVGDP----AVPDDEALWGLILKIRQELDLWVNVRPARLLEGIPGPL---A 110 Query: 126 DIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARK 185 A + D++ VRE + G Y G ++ A ++ V+ R ER+ R AF A Sbjct: 111 GRAPHDVDMVFVRENSEGEYAGVGGRVHRGFGHDVAIESSVFTRRGCERVIRYAFGMASA 170 Query: 186 RRHKVTSIDKANVLQSS-ILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLL 244 R+ + + K+N + W EIV E+ E+P V + M +D + +LI+DP DV++ Sbjct: 171 RKGVLVNATKSNASRFGFPFWDEIVAEVGAEFPGVVVDRMLVDALSARLIRDPGSVDVVV 230 Query: 245 CSNLFGDILSDECAMITGSMGMLPSASLNEQG--FGLYEPAGGSAPDIAGKNIANPIAQI 302 SNLFGDIL+D A + G MGM SA+L+ G L+EP GSAPDIAG+ IANP+ I Sbjct: 231 ASNLFGDILTDIAAALQGGMGMAASANLSPGGGVPALFEPVHGSAPDIAGRGIANPVGAI 290 Query: 303 LSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIA 356 S AL+L L A + + + A+ G RT D+ +T E+GD + Sbjct: 291 WSAALMLE-QLGAGEGSRRLMDALETVCRRGPRTRDV---GGTATTAEVGDAVV 340 >UniRef50_UPI0001B4F4BD putative isocitrate/isopropylmalate dehydrogenase / tartrate dehydrogenase ttuC n=1 Tax=Streptomyces hygroscopicus ATCC 53653 RepID=UPI0001B4F4BD Length = 357 Score = 347 bits (891), Expect = 4e-94, Method: Composition-based stats. Identities = 127/365 (34%), Positives = 187/365 (51%), Gaps = 17/365 (4%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPAT 61 +K +AV+PGDGIGPEV+ + L A R+ + +D GG G +PP Sbjct: 5 TKVVRLAVIPGDGIGPEVVAATVPALRAALEADGHRLDVTSFDWGGERYLRQGAAMPPDA 64 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 + ++ DAVLFG+VG P P+ + G ++ LR+ L NLRP + + G+ Sbjct: 65 ADLVKKTDAVLFGAVGRPD----VPEHELVWGLIIGLRQQLDLAVNLRPVRAFPGVPTKV 120 Query: 122 PLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFE 181 +G D++ VRE T G Y G ++ + V+ R IER A AF Sbjct: 121 -----RDTDGVDLVIVRENTEGEYVGAGGVAHAGSGHDLGIEVAVHSRRAIERAAHQAFA 175 Query: 182 SARKRRHKVTSIDKANVLQSS-ILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQF 240 A +R ++ + K+N ++ LW +V E+ +YP VEL + +D ++I+ P Sbjct: 176 LAGRRSGRLCLVTKSNAMRYGYPLWDRVVREVGEQYPGVELETVLVDAMAARMIQAPRSL 235 Query: 241 DVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQG--FGLYEPAGGSAPDIAGKNIANP 298 DVLL SNLFGDILSD A++ G MGM PSA++ G+YEP GSAPDIAGK +ANP Sbjct: 236 DVLLASNLFGDILSDLAAVLAGGMGMAPSANVLPDAEVPGIYEPVHGSAPDIAGKGVANP 295 Query: 299 IAQILSLALLLRYSLDADDAACAIERAINRALEE-GIRTGDLARGAAAVSTDEMGDIIAR 357 +A +LS A+LL L DAA + A+ L + T DL +T ++ + Sbjct: 296 VACLLSGAMLLE-DLGHTDAARRVRDAVADTLRDTRHHTADL---GGNATTADVASAVLH 351 Query: 358 YVAEG 362 + Sbjct: 352 TMESQ 356 >UniRef50_A5US63 Homoisocitrate dehydrogenase n=6 Tax=Chloroflexi (class) RepID=A5US63_ROSS1 Length = 362 Score = 346 bits (888), Expect = 8e-94, Method: Composition-based stats. Identities = 123/376 (32%), Positives = 183/376 (48%), Gaps = 41/376 (10%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 Y I V+PGDGIG EV+ A+ VL A + + D G G+ LP AT+ Sbjct: 5 PYTILVIPGDGIGREVIPAAVAVLRA----TGLPFHFENADAGWECFQRQGEALPSATLT 60 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 ADA+LFG+V P + R ++ LR+ L++N+RP + Sbjct: 61 AARAADAILFGAVASPGYP-----VAGYRSPIVRLRRELDLYANIRPV-----FDDLPEN 110 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 ++ D++ VRE T +Y G+ + + A V R RI R+A + A Sbjct: 111 GSNPRRRKVDLVVVRENTEDVYAGRERVEDDGAT---AIAERVITRRASARIMRVACDLA 167 Query: 184 RKRR----------HKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQ 232 R RR +VT + KANVL+ + L+R + E+A YPD+++ M +D +Q Sbjct: 168 RARRSARNGSDAPPGRVTVVHKANVLRETCGLFRSVALEVAQAYPDLQIDEMLVDTCALQ 227 Query: 233 LIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAG 292 L P +FDV++ +NLFGDILSD G +G+ PSA+L + L+EP G+APDIAG Sbjct: 228 LATRPERFDVIVTTNLFGDILSDVACAWGGGLGLAPSANLG-ERHALFEPVHGAAPDIAG 286 Query: 293 KNIANPIAQILSLALLLRYSLDADDA---------ACAIERAINRALEEGIRTGDLARGA 343 K IANP+A I ALLL + A + I+RAI G T DL Sbjct: 287 KGIANPLAAIGCTALLLDHLAGRAPADLASAMRGWSARIQRAIRHVRAAGPHTPDL---G 343 Query: 344 AAVSTDEMGDIIARYV 359 + T ++ + + ++ Sbjct: 344 GSAVTTDITNAVLSHM 359 >UniRef50_Q0W5L4 3-isopropylmalate dehydrogenase n=14 Tax=root RepID=Q0W5L4_UNCMA Length = 380 Score = 345 bits (885), Expect = 2e-93, Method: Composition-based stats. Identities = 122/385 (31%), Positives = 186/385 (48%), Gaps = 36/385 (9%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 +Y + V+ GDGIGPEV+ + KV+ A + + + G+ + ++++ Sbjct: 3 SYKVPVIAGDGIGPEVIAEGRKVIAAAQEVYNFDVEWIDMPFSADHYVKTGETISESSLK 62 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 + A+ GS+G + E+G LL +R ++ + NLRP KL +G+E Sbjct: 63 ELSKYRAIFLGSIGD---DRKVKPGVLEKGILLTMRFYYDQYVNLRPVKLMEGVETPLKG 119 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGS-----------------------GQYEK 160 + A D VRE T Y G + E Sbjct: 120 KT---AADIDFYVVRENTEDFYVGIGGRSKKGTSKQELEVIRQMYSVKFGLDVETDSDEI 176 Query: 161 AFDTEVYHRFEIERIARIAFESARKRRHK-VTSIDKANVLQS-SILWREIVNEIATEYPD 218 A+ V + +RI +F+ A R K ++S+DKANVL WRE+ + A +YPD Sbjct: 177 AYQLGVVSKEGAKRIIEYSFDLANSRPKKHLSSVDKANVLTDIYGFWREVFTDTAAKYPD 236 Query: 219 VELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFG 278 V+ Y+D TM +K+P FDV++ N+FGDI++D AMI G +G+ P ++N +G Sbjct: 237 VKTDFNYVDAVTMWFVKNPEFFDVVVSPNMFGDIITDLGAMIQGGLGLAPGGNINPEGTS 296 Query: 279 LYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEE-GIRTG 337 ++EP GGSAP G N NPIA I + A+LL + L AA I AI + L+E IRT Sbjct: 297 MFEPMGGSAPKYKGLNKVNPIATIWAGAMLLEH-LGEKQAAAGIVDAIEQNLKEKKIRTY 355 Query: 338 DLARGAAAVSTDEMGDIIARYVAEG 362 DL + T ++G IAR V + Sbjct: 356 DL---GGSAGTSDVGTDIARIVKQQ 377 >UniRef50_D0DDG4 3-isopropylmalate dehydrogenase n=1 Tax=Citreicella sp. SE45 RepID=D0DDG4_9RHOB Length = 594 Score = 343 bits (881), Expect = 4e-93, Method: Composition-based stats. Identities = 129/325 (39%), Positives = 183/325 (56%), Gaps = 13/325 (4%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATV 62 K Y++A++PGDGIG +V A++VL A + T+ + HG+ +P + Sbjct: 2 KTYNLALIPGDGIGVDVTDAAMEVLGAAA-KGRFAFDTTSFPWSCEYYLEHGRMMPEDGI 60 Query: 63 EGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 E DA+ G+VG W PD G LLP+RK F ++N+RP +L G+E Sbjct: 61 ETLRGFDAIYLGAVG---WPATVPDSVSLHGLLLPIRKAFNQYANIRPHRLLAGVEGP-- 115 Query: 123 LRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFES 182 + A GFDILC+RE T G Y G E A +T V+ R +ERI R FE Sbjct: 116 ----LKAEGFDILCIRENTEGEYSGAGGRVHEGKGNEVAVETSVFTRAGVERILRFGFEQ 171 Query: 183 ARKRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFD 241 AR RR +TS+ K+N + S + W E+ E+A EYPDV ++HM+ID +++ P D Sbjct: 172 ARSRRGHLTSVTKSNAQKYSMVFWDEVTRELAAEYPDVTVSHMHIDAMAAKMVMAPQDLD 231 Query: 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQG--FGLYEPAGGSAPDIAGKNIANPI 299 V++ SNLFGDIL+D A I G +G SA++N ++EP GSAPDIAGKNIANPI Sbjct: 232 VVVASNLFGDILTDLGAAIQGGLGFAASANINPDRSAPSMFEPVHGSAPDIAGKNIANPI 291 Query: 300 AQILSLALLLRYSLDADDAACAIER 324 A I S+A +L + +A+ +A + Sbjct: 292 AAIWSVAQMLDHLGEAEVSAAVLSA 316 >UniRef50_P40495 Homoisocitrate dehydrogenase, mitochondrial n=66 Tax=Dikarya RepID=LYS12_YEAST Length = 371 Score = 343 bits (879), Expect = 9e-93, Method: Composition-based stats. Identities = 120/370 (32%), Positives = 185/370 (50%), Gaps = 33/370 (8%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATV 62 K+ I ++PGDGIG EV+ +VL+ + ++ + G G+ LP TV Sbjct: 22 KSLTIGLIPGDGIGKEVIPAGKQVLENLNSKHGLSFNFIDLYAGFQTFQETGKALPDETV 81 Query: 63 EGCEQ-ADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 + ++ LFG+V P + ++ LR+ LF+N+RP K +G Sbjct: 82 KVLKEQCQGALFGAVQSP-----TTKVEGYSSPIVALRREMGLFANVRPVKSVEG----- 131 Query: 122 PLRADIAANGFDILCVRELTGGIYFGQPK-GREGSGQYEKAFDTEVYHRFEIERIARIAF 180 D++ VRE T +Y K + + A T+ RIA IA Sbjct: 132 -----EKGKPIDMVIVRENTEDLYIKIEKTYIDKATGTRVADATKRISEIATRRIATIAL 186 Query: 181 ESARKR-----RHKVTSIDKANVL-QSSILWREIVNEIAT----EYPDVELAHMYIDNAT 230 + A KR + +T K+NVL QS L+REI E+ +Y ++ +D+ Sbjct: 187 DIALKRLQTRGQATLTVTHKSNVLSQSDGLFREICKEVYESNKDKYGQIKYNEQIVDSMV 246 Query: 231 MQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDI 290 +L ++P FDV++ NL+GDILSD A + GS+G++PSA++ + + EP GSAPDI Sbjct: 247 YRLFREPQCFDVIVAPNLYGDILSDGAAALVGSLGVVPSANVGPE-IVIGEPCHGSAPDI 305 Query: 291 AGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEG-IRTGDLARGAAAVSTD 349 AGK IANPIA I S AL+L + L ++AA I +A++ L EG I+T DL ST Sbjct: 306 AGKGIANPIATIRSTALMLEF-LGHNEAAQDIYKAVDANLREGSIKTPDL---GGKASTQ 361 Query: 350 EMGDIIARYV 359 ++ D + + Sbjct: 362 QVVDDVLSRL 371 >UniRef50_Q1RJU4 Isocitrate dehydrogenase [NADP] n=62 Tax=cellular organisms RepID=IDH_RICBR Length = 483 Score = 342 bits (878), Expect = 1e-92, Method: Composition-based stats. Identities = 104/368 (28%), Positives = 175/368 (47%), Gaps = 30/368 (8%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNH-GQPLPP 59 M++ I + GDGIGPE+M L +L R I +VG H + Sbjct: 1 MAEFTPITIAYGDGIGPEIMEAVLYILRKAEAR----IRLETIEVGEKLYVKHYSSGISE 56 Query: 60 ATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEA 119 + E E+ +L + P+ + + +RK +LF+N+RP+ + Sbjct: 57 QSWESIERTGVILKAPITTPQGGG-------YKSLNVTIRKTLQLFANIRPSVSF----- 104 Query: 120 FCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIA 179 ++ +RE +Y G + + ++ R E+I R A Sbjct: 105 --YPFTKTLHPNLNLTIIRENEEDLYAGIEYRQTHN----MYESVKLISRTGCEKIIRYA 158 Query: 180 FESA-RKRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDP 237 FE A + R KVT + K N+++ S ++ ++ NEIA EYP + H ID T +L P Sbjct: 159 FEYAVKNNRKKVTCLSKDNIMKFSDGIFHKVFNEIAKEYPQINNEHYIIDIGTARLATKP 218 Query: 238 SQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIAN 297 FDV++ SNL+GDI+SD A I+GS+G+ SA++ + + ++E GSAPDIAG++IAN Sbjct: 219 EIFDVIVTSNLYGDIISDVAAEISGSVGLAGSANIG-EHYAMFEAVHGSAPDIAGQDIAN 277 Query: 298 PIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLAR---GAAAVSTDEMGDI 354 P + + ++L + + D A IE A + +E+G+ T D+ V T E + Sbjct: 278 PSGLLNAAIMMLVH-IGQGDIATLIENAWKKTIEDGMHTADIYNKDHSTKKVGTKEFAEE 336 Query: 355 IARYVAEG 362 + + + + Sbjct: 337 VVKRLGQK 344 >UniRef50_P34738 3-isopropylmalate dehydrogenase n=8 Tax=cellular organisms RepID=LEU3_NEUCR Length = 368 Score = 341 bits (875), Expect = 2e-92, Method: Composition-based stats. Identities = 160/371 (43%), Positives = 227/371 (61%), Gaps = 22/371 (5%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAV--RNRFAMRITTSHYDVGGAAIDNHGQPLPPAT 61 ++I V GD GPEV+ +A+KVL A+ + A + ++ +GGA+ID H PL Sbjct: 3 THNIVVFGGDHCGPEVVLEAIKVLKAIETNSPSAGKFNLQNHLLGGASIDKHNDPLTDEA 62 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLY-QGLEAF 120 + + ADAVL G++GGP+W +PE+G LL LRK + NLRP + L Sbjct: 63 LNAAKAADAVLLGAIGGPEW-GTSSTVRPEQG-LLKLRKELGTYGNLRPCNFASESLVDS 120 Query: 121 CPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAF 180 PL+A++ G D + VRELTGGIYFG +GSG A DTE Y R EI RIAR+A Sbjct: 121 SPLKAEVC-RGTDFIVVRELTGGIYFGDRTEDDGSG---YACDTEPYSRAEIVRIARLAG 176 Query: 181 ESARKR--RHKVTSIDKANVLQSSILWREIVNEI-ATEYPDVELAHMYIDNATMQLIKDP 237 A + KV S+DKANVL +S LWR+ V ++ + E+P ++L H ID+A M L+K+P Sbjct: 177 FLALAKNPPAKVWSLDKANVLATSRLWRKTVTDVISKEFPQLQLEHQLIDSAAMLLVKNP 236 Query: 238 SQFD-VLLCSNLFGDILSDECAMITGSMGMLPSASLNE------QGFGLYEPAGGSAPDI 290 + V++ SNLFGDI+SDE ++I GS+G+LPSASL + G+YEP GSAPDI Sbjct: 237 RALNGVVITSNLFGDIISDEASVIPGSIGLLPSASLGGIPDGKGKCNGIYEPIHGSAPDI 296 Query: 291 AGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDE 350 +GK I NP+ ILS+A++LRYSL+ A A+E A+ A++ G +T DL +T + Sbjct: 297 SGKGIVNPVGTILSVAMMLRYSLNLPKEADAVEAAVKAAIDNGTKTKDL---GGNATTSD 353 Query: 351 MGDIIARYVAE 361 MG+ + + + Sbjct: 354 MGNAVVAELEK 364 >UniRef50_A9QPI0 Isocitrate/isopropylmalate dehydrogenase n=3 Tax=Bacteria RepID=A9QPI0_METI4 Length = 482 Score = 341 bits (874), Expect = 3e-92, Method: Composition-based stats. Identities = 104/365 (28%), Positives = 169/365 (46%), Gaps = 30/365 (8%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHG-QPLPPAT 61 K I V GDGIGPE+M LKV+ + ++G + P++ Sbjct: 2 KKVPITVAYGDGIGPEIMDATLKVILEA----GAELEIEKIEIGFKVYSMGNPSGIEPSS 57 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 E ++ L + P+ + + +RK L++N+RP Y Sbjct: 58 WESLKRTKVFLKAPITTPQGGGF-------KSLNVTVRKALGLYANIRPCISYA------ 104 Query: 122 PLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFE 181 G D++ +RE +Y G E + ++ R ERI R AFE Sbjct: 105 -PFIHTKHPGIDLVIIRENEEDLY----GGIEHRQGVDSFQALKIMTRQGTERIIRYAFE 159 Query: 182 SAR-KRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQ 239 AR R KV+S K N+L+ + ++ ++ E+A EYP +E H ID + +L +P Sbjct: 160 YARCYGRKKVSSFTKDNILKITDGMFHKVFEEVAKEYPQIEKEHWIIDIGSAKLADNPQS 219 Query: 240 FDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPI 299 FDVL+ +NL+GDILSD I GS+G+ SA++ + + ++E GSAP AG+N+ANP Sbjct: 220 FDVLVLANLYGDILSDVAVQIAGSVGLGASANIGHE-YSMFEAIHGSAPRRAGQNVANPS 278 Query: 300 AQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGA---AAVSTDEMGDIIA 356 +L+ +L + + + A + A + +EEGI T D+ R V T E + Sbjct: 279 GLLLAAVQMLIH-IGQNAVADRVYNAWLKTIEEGIHTYDIFREGVSKVKVGTREFARHVI 337 Query: 357 RYVAE 361 + + + Sbjct: 338 KNLGK 342 >UniRef50_A1SWV5 3-isopropylmalate dehydrogenase n=1 Tax=Psychromonas ingrahamii 37 RepID=A1SWV5_PSYIN Length = 368 Score = 341 bits (874), Expect = 3e-92, Method: Composition-based stats. Identities = 149/363 (41%), Positives = 215/363 (59%), Gaps = 6/363 (1%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNR-FAMRITTSHYDVGGAAIDNHGQPLPPATV 62 Y+IA+L GDGIGPEVM +A+KVL + R + + G AA G P T Sbjct: 3 TYNIALLAGDGIGPEVMKEAVKVLKLIEQRNEDVNFELNDVLFGAAAYFAMGHAFPDETK 62 Query: 63 EGCEQADAVLFGSVG--GPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAF 120 C++ADA+L G++G + +P D+QPERGALLPLR+ + F+N RP L +GL F Sbjct: 63 AACDKADAILKGTIGLNHEDSKKIPIDEQPERGALLPLRRRYNTFANFRPVYLPKGLAHF 122 Query: 121 CPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAF 180 PL+A + G DI+ +REL GG+YFG+ + + + Y +I +I ++ F Sbjct: 123 SPLKASVIGEGIDIMIIRELVGGLYFGEKEMGVNADGKRFVREVLEYDEDQIRQIVKVGF 182 Query: 181 ESARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQF 240 E + KR+ + +I K+NVL+SS+LW EIV E + YP+VE+ ++ +D A L +P F Sbjct: 183 EVSMKRKKVMHNIHKSNVLKSSVLWNEIVEEESKNYPEVEVKNILVDAAATYLCLNPGMF 242 Query: 241 DVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIA 300 DV++ N+FGDILSD+ I GS+G++PSA YEP+ GSAPDIAGK IANP + Sbjct: 243 DVMVMENMFGDILSDQGGGILGSLGLMPSACKGPD-KSYYEPSHGSAPDIAGKGIANPYS 301 Query: 301 QILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAA--VSTDEMGDIIARY 358 I S+AL+L S + A + A+ E G T DL++ A VST E GD++ Sbjct: 302 MIGSVALMLEMSFGLEKEAKNLWAAMQAVFENGYSTSDLSKEGEANLVSTAEFGDLVCAE 361 Query: 359 VAE 361 +A+ Sbjct: 362 LAK 364 >UniRef50_Q12545 3-isopropylmalate dehydrogenase n=54 Tax=cellular organisms RepID=LEU3_CEPAC Length = 380 Score = 341 bits (874), Expect = 3e-92, Method: Composition-based stats. Identities = 157/383 (40%), Positives = 220/383 (57%), Gaps = 36/383 (9%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRN-RFAMRITTSHYDVGGAAIDNHGQPLPP 59 M+ Y I VLPGD IGPE+M +A+KVL + R + + VGG +ID HG P+ Sbjct: 1 MTTTYKILVLPGDHIGPEIMAEAIKVLTTIETHRPNLHFNLTTDLVGGTSIDTHGVPITQ 60 Query: 60 ATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLY-QGLE 118 + ++ + +DAVLFGS+GGP+W + P + LL LR+H F+NLRP + L Sbjct: 61 SVLDAAKASDAVLFGSIGGPEWAGVHPTPE---SGLLQLRQHLDAFANLRPCEFLVPSLV 117 Query: 119 AFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARI 178 P+R + G + VRE GG YFG+ K E + A D VY R EIER+AR+ Sbjct: 118 GASPIREHVV-KGTRFIVVRENCGGAYFGEKKEEE-----DVASDLWVYTRPEIERLARV 171 Query: 179 AFESARKRRH--------KVTSIDKANVLQSSILWREIVNEI-ATEYPDVELAHMYIDNA 229 + AR V S DKANVL S LWR I ++I A E+PD+ L H D+ Sbjct: 172 SAAVARIMGRSEDDNQAATVWSADKANVLASGRLWRRITSDIFAKEFPDITLQHQLADSM 231 Query: 230 TMQLIKDPSQFD-VLLCSNLFGDILSDECAMITGSMGMLPSASL------NEQGFGLYEP 282 M +++DP +F+ V+ N FGDILSD ITG++G++PSASL + G+YEP Sbjct: 232 AMLMVRDPRRFNGVIHTDNTFGDILSDISGAITGTLGLMPSASLCGVPGEGHRSNGIYEP 291 Query: 283 AGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEG------IRT 336 GSAPDI+GK +ANP+AQILS+A++LRYS+ + A A+ERA+ + L+ IRT Sbjct: 292 VHGSAPDISGKGLANPVAQILSVAMMLRYSMGLEKEATAVERAVVKVLDAKSEGGLEIRT 351 Query: 337 GDLARGAAAVSTDEMGDIIARYV 359 GDL + ++GD + + Sbjct: 352 GDL---GGRATCSQVGDAVCEVL 371 >UniRef50_B0ER68 Tartrate dehydrogenase, putative n=2 Tax=Entamoeba RepID=B0ER68_ENTDI Length = 370 Score = 340 bits (872), Expect = 5e-92, Method: Composition-based stats. Identities = 124/359 (34%), Positives = 197/359 (54%), Gaps = 21/359 (5%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 + I V+PGDGIG EVM++A K+ ++ + I + D G G+ +P ++ Sbjct: 10 QHKIIVIPGDGIGVEVMSEAEKMFQSLN----LPIQRDYVDWGIQHYLKTGKVVPIDYID 65 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 +Q DA+L GS+G P+ +P L+ +R+ F LRPAK + G+ Sbjct: 66 QVKQYDAILLGSLGDPRTLPDYVTLEP----LIQMRQQLDQFLCLRPAKHFPGIPTP--- 118 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 + DIL VRE + G Y + E A ++ V+ R +ER+ R AFE++ Sbjct: 119 ---LKKCEIDILVVRENSEGEYSNIGGIFKSGTPDEFAIESAVHTRRGLERVIRYAFEAS 175 Query: 184 RKRRHKVTSIDKANVLQS-SILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDV 242 RKRR+ VT K+N ++ +LW + IA EYPDV Y+D + +++K+PS+FDV Sbjct: 176 RKRRNHVTLATKSNAMKYGMVLWDSVFEAIAMEYPDVTAEKYYMDALSAEIVKNPSKFDV 235 Query: 243 LLCSNLFGDILSDECAMITGSMGMLPSASLNEQG--FGLYEPAGGSAPDIAGKNIANPIA 300 ++ SNLF DI+SD + GSMG+ PSA++N + L+EP GSA DIAGK I +PI Sbjct: 236 IVGSNLFCDIISDLTVTVAGSMGIAPSANINPERTFPSLFEPVHGSALDIAGKGICDPIG 295 Query: 301 QILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYV 359 + + +++L + L + + IE AI ++ + I T D+ +T+E+G+ IA Y+ Sbjct: 296 TMRASSMMLEF-LGYSEESVLIEEAIQSSILQKITTIDI---GGTKTTNEVGNFIADYI 350 >UniRef50_P28241 Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial n=34 Tax=cellular organisms RepID=IDH2_YEAST Length = 369 Score = 339 bits (870), Expect = 8e-92, Method: Composition-based stats. Identities = 108/363 (29%), Positives = 174/363 (47%), Gaps = 36/363 (9%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 Y ++ + GDGIGPE+ K+ A + I DV N +P V+ Sbjct: 36 KYTVSFIEGDGIGPEISKSVKKIFSAAN----VPIEWESCDVSPI-FVNGLTTIPDPAVQ 90 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 + L G + P + R L LRK F LF+N+RPAK +G + Sbjct: 91 SITKNLVALKGPLATPIG-------KGHRSLNLTLRKTFGLFANVRPAKSIEGFKT---- 139 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 D++ +RE T G Y G E ++ R ER+ R AFE A Sbjct: 140 ----TYENVDLVLIRENTEGEYSG----IEHIVCPGVVQSIKLITRDASERVIRYAFEYA 191 Query: 184 RK-RRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFD 241 R R +V + K+ + + + L+ + E++ EYPD+ L IDN+ ++++ +PS + Sbjct: 192 RAIGRPRVIVVHKSTIQRLADGLFVNVAKELSKEYPDLTLETELIDNSVLKVVTNPSAYT 251 Query: 242 --VLLCSNLFGDILSDECAMI-TGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANP 298 V +C NL+GDILSD + + GS+G+ PSA++ + ++E GSAPDIAG++ ANP Sbjct: 252 DAVSVCPNLYGDILSDLNSGLSAGSLGLTPSANIGHK-ISIFEAVHGSAPDIAGQDKANP 310 Query: 299 IAQILSLALLLRYSLDADDAACAIERAINRALEEGI--RTGDLARGAAAVSTDEMGDIIA 356 A +LS ++L + + + A I+ A+ + G RTGDL A +T + + Sbjct: 311 TALLLSSVMMLNH-MGLTNHADQIQNAVLSTIASGPENRTGDL---AGTATTSSFTEAVI 366 Query: 357 RYV 359 + + Sbjct: 367 KRL 369 >UniRef50_C1F3J9 Isocitrate dehydrogenase n=1 Tax=Acidobacterium capsulatum ATCC 51196 RepID=C1F3J9_ACIC5 Length = 502 Score = 338 bits (867), Expect = 2e-91, Method: Composition-based stats. Identities = 98/364 (26%), Positives = 166/364 (45%), Gaps = 30/364 (8%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQP-LPPATV 62 + V GDGIGPE+ + +L A + + +VG +P Sbjct: 21 PIPVTVAAGDGIGPEITAAVMSILSAA----GAHLDAEYVEVGEQVYLRGNTSGIPQEAW 76 Query: 63 EGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 + + +L G + P+ + + +RK L++N+RP + Y+ + Sbjct: 77 DSIARTRVMLKGPITTPQGGG-------YKSLNVTMRKTLGLYANVRPCRTYKPIVT--- 126 Query: 123 LRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFES 182 D++ VRE +Y G + + A ++ R ERIAR AFE Sbjct: 127 ----TRHPDMDVVIVRENEEDLYAGIEHRQ----TQDVAQCLKLITRSGSERIARYAFEY 178 Query: 183 ARKR-RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQF 240 AR+ R K+T + K N+++ + L+ + +E+A EYP+++ +D + P + Sbjct: 179 ARQHGRSKITCMIKDNIMKLTDGLFHRVFDEVAREYPEIQAHSQIVDFGMANFVHRPEDY 238 Query: 241 DVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIA 300 DV+L NL+GDILSD A +TGS+G+ S ++ G ++E GSAPD+A +++ANP Sbjct: 239 DVVLLPNLYGDILSDIAAQMTGSVGLGGSVNIG-SGGAIFEAIHGSAPDLA-RDVANPSG 296 Query: 301 QILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLAR--GAAAVSTDEMGDIIARY 358 +L+ +LR+ L D A + A LEEGI T D+A T + + Sbjct: 297 LLLAAVEMLRH-LKLDSIAAKVMNAWLCTLEEGIHTVDIAGAHTKERAGTRRFTEAVIER 355 Query: 359 VAEG 362 + Sbjct: 356 LGRR 359 >UniRef50_D0RN50 Threo-isocitrate dehydrogenase [NAD] n=1 Tax=alpha proteobacterium HIMB114 RepID=D0RN50_9RICK Length = 357 Score = 338 bits (867), Expect = 2e-91, Method: Composition-based stats. Identities = 118/372 (31%), Positives = 189/372 (50%), Gaps = 26/372 (6%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPA 60 MS N VL GDGIGPE+ ++ VL A + +++ + ++G A++ H Sbjct: 1 MS-NLKFLVLEGDGIGPEIAKASVDVLQAALKLYDLKVNLVYEEIGFASLKKHKTTFRSE 59 Query: 61 TVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAF 120 ++ E+ D ++ G+ + PP ++ +RK+F L++N+RPAK G Sbjct: 60 VLKIAEKCDGMILGTCSHNDY---PPTEEGGLNPSGVIRKYFDLYANVRPAKNRLGKLER 116 Query: 121 CPLRADIAANGFDILCVRELTGGIYFGQP---KGREGSGQYEKAFDTEVYHRFEIERIAR 177 P+ G D L +RE T G Y + E + A R RIA Sbjct: 117 FPM-------GIDCLVMRENTEGFYSDRNMFKGVGELMPTPDVAISIRNITRKGSTRIAE 169 Query: 178 IAFESARKRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKD 236 I F+ A +RR K+ +I KANVL+ S L+ E +++ +YP+VE +D+ + LI+D Sbjct: 170 IGFKYAMERRKKLVAIHKANVLRYSDGLFLECARQVSKKYPEVEYKEQIVDSMSAMLIRD 229 Query: 237 PSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIA 296 PS FDV+L +NLFGD LSD + I G +G+ S + + + + + GSAPDIAGKNIA Sbjct: 230 PSVFDVILATNLFGDNLSDAASEIAGGLGLAESINAG-ENYCIAQAQHGSAPDIAGKNIA 288 Query: 297 NPIAQILSLALLLRYSL------DADDAACAIERAINRALEE-GIRTGDLARGAAAVSTD 349 NP++ I S A++L + + A IE AI++ + RT D+ +ST Sbjct: 289 NPVSLIGSTAMMLDWLGKKNNNQQLKEIAQMIEDAIDKTIINPKTRTSDI---GGNLSTT 345 Query: 350 EMGDIIARYVAE 361 + D++ + + Sbjct: 346 DFTDVLISNLKK 357 >UniRef50_A6WAX5 3-isopropylmalate dehydrogenase n=20 Tax=Bacteria RepID=A6WAX5_KINRD Length = 377 Score = 337 bits (864), Expect = 4e-91, Method: Composition-based stats. Identities = 128/368 (34%), Positives = 194/368 (52%), Gaps = 26/368 (7%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAM-RITTSHYDVGGAAIDNHGQPLPPA 60 SK Y +AVL GDGIGPE++ ++K+LDA I + +G +AID +G+ P Sbjct: 21 SKQYSLAVLHGDGIGPEIVPASVKILDAAVAAAGATPIAWTELPLGRSAIDEYGEHTPTK 80 Query: 61 TVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAF 120 T++ ++ D L G P + + +RKHF LF+N+RPAK ++G Sbjct: 81 TLDALDEVDGWLLGPH---DSAAYPEPYRSQLNPSGTIRKHFGLFANIRPAKAFRG---- 133 Query: 121 CPLRADIAANGFDILCVRELTGGIYFGQP---KGREGSGQYEKAFDTEVYHRFEIERIAR 177 + G D++ VRE T G Y + E + A + R ERIA Sbjct: 134 ----GNAIVEGTDLVIVRENTEGFYADRNTFAGTGEMMPTPDVAIMHGIITRAATERIAH 189 Query: 178 IAFESARKRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKD 236 AF+ AR R +VT + KANVL+ ++ L+R++ E+ +YPDV + +ID AT+ L++ Sbjct: 190 EAFQLARTRDKRVTIVHKANVLKMTTGLFRDVCREVGKQYPDVAINDFHIDAATVHLVRR 249 Query: 237 PSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIA 296 +FDV++ N+FGDILSD + GS+G+ PS + + + + + GSAPDIAG++IA Sbjct: 250 ADKFDVIVTENMFGDILSDLAGEVAGSLGIAPSIN-SSATHAMAQASHGSAPDIAGRDIA 308 Query: 297 NPIAQILSLALLLRYSLDADD------AACAIERAINRALEEGIRTGDLARGAAAVSTDE 350 NPIA ILS A+LLR+ D AA +E A++ + EG T D+ S Sbjct: 309 NPIAMILSSAMLLRWLAAKFDDEKIARAADIVEAAVDLTVAEGATTPDM---GGTSSCSG 365 Query: 351 MGDIIARY 358 D + Sbjct: 366 FADAVVAA 373 >UniRef50_O81796 Isocitrate dehydrogenase [NAD] regulatory subunit 3, mitochondrial n=42 Tax=Eukaryota RepID=IDH3_ARATH Length = 368 Score = 336 bits (862), Expect = 7e-91, Method: Composition-based stats. Identities = 99/372 (26%), Positives = 169/372 (45%), Gaps = 45/372 (12%) Query: 1 MSKN-----YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQ 55 M + + ++PGDGIGP V +V++A+ + Y+V G + + Sbjct: 30 MPRPGDGAPRTVTLIPGDGIGPLVTGAVEQVMEAMHA----PVHFERYEVLG-----NMR 80 Query: 56 PLPPATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQ 115 +P +E ++ L G + P + + LRK +F++L Sbjct: 81 KVPEEVIESVKRNKVCLKGGLATPVGGGVS-------SLNMQLRKELDIFASLVNCINVP 133 Query: 116 GLEAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERI 175 GL DI+ +RE T G Y G E +V +F ERI Sbjct: 134 GLVT--------RHENVDIVVIRENTEGEYSG----LEHEVVPGVVESLKVITKFCSERI 181 Query: 176 ARIAFESA-RKRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQL 233 AR AFE A R KVT++ KAN+++ + L+ E E+A Y + + +DN MQL Sbjct: 182 ARYAFEYAYLNNRKKVTAVHKANIMKLADGLFLESCREVAKHYSGITYNEIIVDNCCMQL 241 Query: 234 IKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSA----PD 289 + P QFDV++ NL+G+++++ A I G G++P ++ + ++E + Sbjct: 242 VAKPEQFDVMVTPNLYGNLIANTAAGIAGGTGVMPGGNVGAE-HAIFEQGASAGNVGNDK 300 Query: 290 IAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEG-IRTGDLARGAAAVST 348 + + ANP+A +LS A++LR+ L A +E A+ + ++EG RT DL +T Sbjct: 301 MVEQKKANPVALLLSSAMMLRH-LRFPTFADRLETAVKQVIKEGKYRTKDL---GGDCTT 356 Query: 349 DEMGDIIARYVA 360 E+ D + + Sbjct: 357 QEVVDAVIAALE 368 >UniRef50_A5UMS5 3-isopropylmalate dehydrogenase, LeuB n=8 Tax=Euryarchaeota RepID=A5UMS5_METS3 Length = 336 Score = 334 bits (858), Expect = 2e-90, Method: Composition-based stats. Identities = 130/360 (36%), Positives = 190/360 (52%), Gaps = 35/360 (9%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATV 62 Y IAV+PGDGIG EVM + VLD + + + G + HG PLP T+ Sbjct: 9 NKYQIAVIPGDGIGKEVMEATISVLDEL----DVDFDYIYGIAGDECNEEHGTPLPQETI 64 Query: 63 EGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 + +DA LFG+ G + ++ +R+ K+F+NLRP K Y ++ Sbjct: 65 DIVRDSDACLFGAAG-----------ETAADVIVKIRQEMKMFANLRPVKSYPNTKSL-- 111 Query: 123 LRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFES 182 D + VRE T G+Y + G A V R ERI AF+ Sbjct: 112 ------FENVDFMIVRENTEGLYIADQEEETEDG----AIAKRVITREAEERIIDYAFQY 161 Query: 183 AR-KRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQF 240 A+ R KVT++ KANVL+ + L+++I E+ +YPD++ Y+D M L+ P +F Sbjct: 162 AKDNNRTKVTAVHKANVLKKTDGLFKKIFYEVGEKYPDIDTEDFYVDATAMYLVTQPQEF 221 Query: 241 DVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIA 300 V++ +NLFGDILSDE A + G +G++PSA++ G L+EP GSAPDIAG+ ANPIA Sbjct: 222 QVVVTTNLFGDILSDEGAGLVGGLGLIPSANIGADG-ALFEPVHGSAPDIAGQQKANPIA 280 Query: 301 QILSLALLLRYSLDADDAACAIERAINRALEEGI-RTGDLARGAAAVSTDEMGDIIARYV 359 +LS ++LRY L +DAA + AI + L EG TGDL + +T E+ + + Sbjct: 281 MMLSAIMMLRY-LGENDAADKFDAAILKVLSEGKTLTGDL---GGSATTMEVAQAVKNAL 336 >UniRef50_P41564 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (Fragment) n=17 Tax=Bilateria RepID=IDH3G_MACFA Length = 355 Score = 334 bits (857), Expect = 3e-90, Method: Composition-based stats. Identities = 94/360 (26%), Positives = 156/360 (43%), Gaps = 32/360 (8%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 + + ++PGDGIGPE+M V + I N + Sbjct: 16 RHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFEEVHVSSNADEEDIRN--------AIM 67 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 + L G++ +LPP + LR L++N+ K G+ Sbjct: 68 AIRRNRVALKGNIET--NHNLPP---SHKSRNNILRTSLDLYANVIHCKSLPGVVT---- 118 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 DIL VRE T G Y E ++ + + RIA AF+ A Sbjct: 119 ----RHKDIDILIVRENTEGEYSS----LEHESVAGVVESLKIITKAKSLRIAEYAFKLA 170 Query: 184 RK-RRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFD 241 ++ R KVT++ KAN+++ L+ + E+A YP + +M +DN TMQL+ P QFD Sbjct: 171 QESGRKKVTAVHKANIMKLGDGLFLQCCREVAARYPQITFENMIVDNTTMQLVSRPQQFD 230 Query: 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQ 301 V++ NL+G+I+++ CA + G G++ A+ + IA KNIANP A Sbjct: 231 VMVMPNLYGNIVNNVCAGLVGGPGLVAGANYGHVYAVFETATRNTGKSIANKNIANPTAT 290 Query: 302 ILSLALLLRYSLDADDAACAIERAINRAL-EEGIRTGDLARGAAAVSTDEMGDIIARYVA 360 +L+ ++L + L A +I +A+ ++ E + T D+ +T E I R++ Sbjct: 291 LLASCMMLDH-LKLHSYATSIRKAVLASMDNENMHTPDIGGQG---TTSEAIQDIIRHIR 346 >UniRef50_Q0BQF4 Isocitrate dehydrogenase (NADP) n=14 Tax=Proteobacteria RepID=Q0BQF4_GRABC Length = 348 Score = 333 bits (855), Expect = 5e-90, Method: Composition-based stats. Identities = 124/366 (33%), Positives = 175/366 (47%), Gaps = 32/366 (8%) Query: 1 MSKNYHI--AVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLP 58 MS+ I ++PGDGIGPE++ + VLDA+ G AAI G PLP Sbjct: 7 MSQTTKIPATLIPGDGIGPEIVESVVSVLDAL----GSPFEWDSQYAGMAAIARVGDPLP 62 Query: 59 PATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLE 118 T++ L G + P R + LRK F+LF+N+RPA Sbjct: 63 RETIQSIHHNKLALKGPLTTPTGGG-------YRSVNVQLRKEFELFANVRPA------- 108 Query: 119 AFCPLRADIAANGFDILCVRELTGGIYFGQPKGRE-GSGQYEKAFDTEVYHRFEIERIAR 177 L DI +RE G Y G + A R RI R Sbjct: 109 --LTLIPGGRFENVDITLIRENLDGFYAAFEHYMPIGDDPHAVAMCAGFNTRTGCHRIIR 166 Query: 178 IAFESARKR-RHKVTSIDKANVLQS-SILWREIVNEIATEYPD-VELAHMYIDNATMQLI 234 AFE A + R KVT + KAN+L++ + ++ E EIA EY + +D MQL+ Sbjct: 167 YAFEYAMQNGRKKVTLVHKANILKALTGIFLEAGKEIAKEYEGRIAFEERIVDACAMQLV 226 Query: 235 KDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKN 294 DP +FDV++ +NLFGDILSD A + G +G+ P ++ +Q ++E GSAPDIAGK Sbjct: 227 LDPGRFDVIVTTNLFGDILSDLIAGLIGGLGLAPGGNIGKQ-AAIFEAVHGSAPDIAGKG 285 Query: 295 IANPIAQILSLALLLRYSLDADDAACAIERAIN-RALEEGIRTGDLARGAAAVSTDEMGD 353 IANP+A +L+ A++L + + D A + AI LE+GIRT DL T E+ Sbjct: 286 IANPLALMLAAAMMLDH-VGKTDLATRLRNAIRITTLEDGIRTPDL---GGTAKTRELTQ 341 Query: 354 IIARYV 359 + + Sbjct: 342 ALISRI 347 >UniRef50_P51553 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial n=41 Tax=Euteleostomi RepID=IDH3G_HUMAN Length = 393 Score = 333 bits (855), Expect = 6e-90, Method: Composition-based stats. Identities = 93/360 (25%), Positives = 156/360 (43%), Gaps = 32/360 (8%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 + + ++PGDGIGPE+M V + I N + Sbjct: 54 RHTVTMIPGDGIGPELMLHVKSVFRHACVPVDFEEVHVSSNADEEDIRN--------AIM 105 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 + L G++ +LPP + LR L++N+ K G+ Sbjct: 106 AIRRNRVALKGNIET--NHNLPP---SHKSRNNILRTSLDLYANVIHCKSLPGVVT---- 156 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 DIL VRE T G Y E ++ + + RIA AF+ A Sbjct: 157 ----RHKDIDILIVRENTEGEYSS----LEHESVAGVVESLKIITKAKSLRIAEYAFKLA 208 Query: 184 RK-RRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFD 241 ++ R KVT++ KAN+++ L+ + E+A YP + +M +DN TMQL+ P QFD Sbjct: 209 QESGRKKVTAVHKANIMKLGDGLFLQCCREVAARYPQITFENMIVDNTTMQLVSRPQQFD 268 Query: 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQ 301 V++ NL+G+I+++ CA + G G++ A+ + IA KNIANP A Sbjct: 269 VMVMPNLYGNIVNNVCAGLVGGPGLVAGANYGHVYAVFETATRNTGKSIANKNIANPTAT 328 Query: 302 ILSLALLLRYSLDADDAACAIERAINRAL-EEGIRTGDLARGAAAVSTDEMGDIIARYVA 360 +L+ ++L + L A +I +A+ ++ E + T D+ +T E + R++ Sbjct: 329 LLASCMMLDH-LKLHSYATSIRKAVLASMDNENMHTPDIGGQG---TTSEAIQDVIRHIR 384 >UniRef50_A8TPC9 3-isopropylmalate dehydrogenase n=3 Tax=Alphaproteobacteria RepID=A8TPC9_9PROT Length = 371 Score = 333 bits (853), Expect = 8e-90, Method: Composition-based stats. Identities = 130/369 (35%), Positives = 179/369 (48%), Gaps = 25/369 (6%) Query: 5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEG 64 Y IAV+PGDGIGPEV ++VL + I YD G G P AT Sbjct: 13 YRIAVVPGDGIGPEVSAATVRVLTQALG-TSFPIEFRDYDAGAECFRRTGTAFPEATQVA 71 Query: 65 CEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 C QA AVL G+ G P P + + + +R L++N+RP +L +G + Sbjct: 72 CRQAHAVLHGAAGLPDVL-FPDGTEAGQDFSMKIRAALDLYANVRPIRLMEGAPRRLVGK 130 Query: 125 ADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESAR 184 + VRE T G+Y + G GQ A DT V R +ERI R A E AR Sbjct: 131 G---PDDIRFTIVRENTEGLYAARGGGNIIRGQ--IATDTLVMTREGVERIVRYAAELAR 185 Query: 185 KRR-------HKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDP 237 + +VT +DKANVL+S +REI + + + P +E+ H+ +D T+ +I+ P Sbjct: 186 DGQGAPADGVRRVTIVDKANVLRSYAFFREIADGVLADCPGIEVEHVIVDAMTVHMIERP 245 Query: 238 SQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIAN 297 FDV++C NLFGDILSD A I G MG+ PS + G ++ + GSAP IAGK +AN Sbjct: 246 EHFDVIVCENLFGDILSDLGAAIMGGMGLAPSGEIGRD-HGYFQGSHGSAPTIAGKGLAN 304 Query: 298 PIAQILSLALLLRYSLDAD------DAACAIERAINRALEEG-IRTGDLARGAAAVSTDE 350 PIA ILS A++L + AA I A L+ G T D+ + S Sbjct: 305 PIACILSGAMMLDWLGKRHSDPALTRAAERIREATGAVLKAGRAVTPDIGGSGSTESCAA 364 Query: 351 MGDIIARYV 359 I + Sbjct: 365 ---EICATL 370 >UniRef50_D0LNY3 3-isopropylmalate dehydrogenase n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LNY3_HALO1 Length = 400 Score = 333 bits (853), Expect = 9e-90, Method: Composition-based stats. Identities = 119/363 (32%), Positives = 173/363 (47%), Gaps = 24/363 (6%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHG-QPLPPA 60 +Y + +LPGDGIGPEVM QA +L+AV +R GG HG + P Sbjct: 7 KDSYQVVLLPGDGIGPEVMAQARDLLEAVAEPSGVRFELDEIPCGGRFYLEHGARDWPED 66 Query: 61 TVEGCEQADAVLFGSVGGPKWEHLPP-----DQQPERGALLPLRKHFKLFSNLRPAKLYQ 115 C AD +L G+VG P + P A++ R L++N+RP KL Sbjct: 67 AEARCRGADVILLGAVGWPSPDGPGPVMMGNGNMAGHSAVIGNRVDLDLYANVRPVKLLP 126 Query: 116 GLEAFC--PLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIE 173 G+ + D++ +RE T G+Y G G A DT + R E Sbjct: 127 GVAHRISGTRQQVWRPEHVDMVILRENTEGLYAGMGGQLRVGGSASVATDTRLITRRGCE 186 Query: 174 RIARIAFESARKRR--------HKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMY 225 RI R AFE +R +VT I K NVL+ L+ E+ E+A+EYPD+ Sbjct: 187 RIIRRAFELCEQRGRGAPGDGVKRVTGIVKHNVLEGCKLFAEVFAEVASEYPDIANELAI 246 Query: 226 IDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGG 285 +D T L+ P +DV + +NLFGDI++D +++ G MGM ++ ++ ++EP G Sbjct: 247 VDAFTQWLVTQPEHYDVCVTTNLFGDIVTDLASVLQGGMGMAVGCNVGDE-HAMFEPIHG 305 Query: 286 SAPDIAGKNIANPIAQILSLALLLRYSLDADD------AACAIERAINRALEEG-IRTGD 338 SAP +AGK+ ANP+A +L+ L + D A A+ERA+ E G T D Sbjct: 306 SAPPLAGKDEANPMAMLLATGEALAWLGQRHDDPRLRAIAHAVERAVATVAERGAPLTVD 365 Query: 339 LAR 341 L Sbjct: 366 LVG 368 >UniRef50_O59930 3-isopropylmalate dehydrogenase n=12 Tax=cellular organisms RepID=LEU3_PHACH Length = 380 Score = 332 bits (852), Expect = 1e-89, Method: Composition-based stats. Identities = 159/385 (41%), Positives = 220/385 (57%), Gaps = 27/385 (7%) Query: 1 MSKN-YHIAVLPGDGIGPEVMTQALKVLDAV-RNRFAMRITTSHYDVGGAAIDNHGQPLP 58 MSK + I +LPGDGIGPEV+ +A +VL+ V + + I +D GG +ID HG+PL Sbjct: 1 MSKRTFKIVILPGDGIGPEVVAEATRVLEVVSASSSDVEIKLETHDFGGCSIDKHGEPLT 60 Query: 59 PATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLE 118 AT+E C+ ADA+L G++GGPKW + +PE+ ALL LRK L++N+RPA Sbjct: 61 AATLEACKLADAILLGAIGGPKW-GVNSKVRPEQ-ALLALRKALGLYANIRPANFASDSL 118 Query: 119 AFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARI 178 A G DI+ +REL GG YFG+ K Q + A+DT +Y E++RI R Sbjct: 119 LAYSPLKPSVARGVDIIVIRELIGGAYFGERKELGARAQEDAAWDTMIYSVPEVQRITRS 178 Query: 179 AFESARKRRH-KVTSIDKANVLQSSILWREIVNE-IATEYPDVELAHMYIDNATMQLIKD 236 + A V SIDKANVL SS LWR++ E I E+P ++L H +D+A+M ++ + Sbjct: 179 RRQVASPDPPLPVHSIDKANVLASSRLWRKVATETIQNEFPQLKLDHHLVDSASMLIVAN 238 Query: 237 PSQFD-VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFG------------LYEPA 283 P + + V+L NLFGDILSDE ++I GS+G+LPSASL + +YEP Sbjct: 239 PKKLNGVILTENLFGDILSDESSVIPGSLGLLPSASLAARPLWPNTAHRRSSPRRVYEPI 298 Query: 284 GGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRA-----LEEGIRTGD 338 GSAPDIAG+ IANPI ILS A+L A AIE A+ A EG+RT D Sbjct: 299 HGSAPDIAGQGIANPIGTILSAAMLCGTRSVWRSPAKAIEAAVEGARRQGDRREGLRTAD 358 Query: 339 LARGAAAVSTDEMGDIIARYVAEGV 363 L + T ++G + + + Sbjct: 359 L---GGSSKTKDIGHKVVEILKATL 380 >UniRef50_D2VFR4 Homo-isocitrate dehydrogenase n=1 Tax=Naegleria gruberi RepID=D2VFR4_NAEGR Length = 384 Score = 331 bits (849), Expect = 3e-89, Method: Composition-based stats. Identities = 118/374 (31%), Positives = 188/374 (50%), Gaps = 44/374 (11%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAV------RNRFAMRITTSHYDVGGAAIDNHGQPLPPA 60 I V+P DGIG EV+ A++V++A + + + G G+ LP Sbjct: 34 IGVIPADGIGKEVVPAAVQVMNAAIAKNVKAKQNDFSLQYIPLEAGWETFQKTGKSLPVE 93 Query: 61 TVEGCE-QADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEA 119 TVE + + D +FGSV P + + ++ +RK L++N+RP + Sbjct: 94 TVEALKNKCDGAIFGSVQSPSHK-----VEGYSSPIVAMRKLVDLYANIRPCQDL----- 143 Query: 120 FCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYE-KAFDTEVYHRFEIERIARI 178 A G D+L VRE T +Y + K E A + +RIA I Sbjct: 144 ---------AKGIDMLIVRENTECLYIKKEKLTVDPTTGEKTAVADRLITERASKRIAEI 194 Query: 179 AFESARKRRH----KVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQL 233 A++ A +R KVT + K+NVL S L+RE EI+ +YP V+ +D+ ++ Sbjct: 195 AYKLAVQRNKNGAPKVTIVHKSNVLSVSDGLFRESCLEISKKYPQVKTEEQLVDSMVYKM 254 Query: 234 IKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGK 293 I DP+Q+DV++ NL+GDILSD + G +G+ SA+L++ F L EP GSAPDI GK Sbjct: 255 ILDPTQYDVVVAPNLYGDILSDAGSAFVGGLGVTASANLSDS-FALVEPVHGSAPDIFGK 313 Query: 294 NIANPIAQILSLALLLRYSLD-------ADDAACAIERAINRALEEG-IRTGDLARGAAA 345 I+NPIA I + A+LLR+ + ++ A +++RA+N + + + T DL Sbjct: 314 KISNPIATIRACAMLLRHLQEKDPKCSYLNEIADSMDRAVNVVMPDKTVTTPDLGGKG-- 371 Query: 346 VSTDEMGDIIARYV 359 +T+ + D I + + Sbjct: 372 -NTETLVDAIIKNL 384 >UniRef50_Q47SB4 3-isopropylmalate dehydrogenase n=15 Tax=cellular organisms RepID=LEU3_THEFY Length = 354 Score = 330 bits (847), Expect = 4e-89, Method: Composition-based stats. Identities = 147/367 (40%), Positives = 209/367 (56%), Gaps = 19/367 (5%) Query: 1 MS-KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPP 59 MS + +AV+PGDGIGPEV+ + LKVL AV R + + T+ Y++G G+ LP Sbjct: 1 MSARTVKLAVIPGDGIGPEVVAEGLKVLSAVAPRHGLTLDTTEYELGAQRWHATGEVLPD 60 Query: 60 ATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEA 119 A E Q DA+L G+VG P P ERG LL LR +F + NLRP +LY G+ Sbjct: 61 AVEEELRQHDAILLGAVGDP----TVPSGVLERGLLLRLRFNFSHYVNLRPVRLYPGVTT 116 Query: 120 FCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIA 179 A +A D+L VRE T G Y G +E A V R +ER+ R A Sbjct: 117 PL---AGVAPEDIDMLVVREGTEGPYAGMGGVLRKGTPHEIATQDSVNTRLGVERVVRYA 173 Query: 180 FESARKRR-HKVTSIDKANVLQSSI-LWREIVNEIATEYPDVELAHMYIDNATMQLIKDP 237 F A +R HK+T + K NVL + LW+ +V E+ EYP VE+ ++++D ATM + P Sbjct: 174 FAKAAERPCHKLTLVHKDNVLTYAGELWQRVVREVGAEYPQVEVDYLHVDAATMFFVTQP 233 Query: 238 SQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQG--FGLYEPAGGSAPDIAGKNI 295 +FDV++ NLFGDI++D A + G +G+ S ++N +G ++EP GSAPDIAG+ Sbjct: 234 RRFDVVVTDNLFGDIITDLGAAVAGGIGLAASGNINPEGDFPSMFEPVHGSAPDIAGQGK 293 Query: 296 ANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDII 355 A+P A ILS++L+L + L DAA I++A+ L+E A+ ST ++GD I Sbjct: 294 ADPTATILSVSLMLEH-LGYADAAAQIDQAVAEDLQER------AKNGGVRSTTQIGDDI 346 Query: 356 ARYVAEG 362 A+ VAE Sbjct: 347 AQRVAEQ 353 >UniRef50_B1L3C1 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Korarchaeum cryptofilum OPF8 RepID=B1L3C1_KORCO Length = 334 Score = 329 bits (844), Expect = 1e-88, Method: Composition-based stats. Identities = 124/358 (34%), Positives = 188/358 (52%), Gaps = 33/358 (9%) Query: 5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEG 64 IAV+PGDG+GPE++ + VL+ + + + + ++ G G LP T+ G Sbjct: 2 PRIAVIPGDGVGPEIIDAVIPVLETLSDLMNLPLDLRFFEAGDETKRKRGVALPEETLNG 61 Query: 65 CEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 +DA L ++G + R +LPLR+ L+ NLRPAK Y + P Sbjct: 62 VMNSDATLMVAIG-----------ESAREVILPLRQKLDLYVNLRPAKSYP-VPRAIP-- 107 Query: 125 ADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESAR 184 GFD+ VRE T +Y + A D + R ERI R + AR Sbjct: 108 ------GFDLTIVRENTEDLYVMSGWR-----GLDTAVDLRIITRRASERICRFGYRYAR 156 Query: 185 KRRH-KVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVL 243 +R +V + KANVL +L+RE+ + +A E + MY+D+A M++ D FDV+ Sbjct: 157 ERGKSRVYVVHKANVLGGCMLFREVCSRVAEE-EGFDYREMYVDSAAMRIAMD-RPFDVI 214 Query: 244 LCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQIL 303 + +N+FGDILSD A G +GM PSA++ E ++EP G+AP+IAGKNIANP+A IL Sbjct: 215 ITTNMFGDILSDLAAAFIGGLGMYPSANIGESR-AIFEPVHGTAPEIAGKNIANPMATIL 273 Query: 304 SLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYVAE 361 S A+++ + L + + IE A+ RA E G T D+ ++ T E+G I+ + E Sbjct: 274 SAAMMMGW-LGHEGGSKLIEEAVRRACELGYTTPDV---GGSMRTKEVGLKISEIMRE 327 >UniRef50_Q7UTP0 3-isopropylmalate dehydrogenase n=1 Tax=Rhodopirellula baltica RepID=Q7UTP0_RHOBA Length = 364 Score = 328 bits (842), Expect = 2e-88, Method: Composition-based stats. Identities = 126/369 (34%), Positives = 206/369 (55%), Gaps = 18/369 (4%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRF-AMRITTSHYDVGGAAIDNHGQPLPP 59 M +++H+ +L GDGIGPEV Q++++L+ ++ + + VG G+ LP Sbjct: 1 MPQSFHLVILGGDGIGPEVCDQSVRLLEIMQPHLDGVEFQLDRHSVGVGEYQRSGEALPQ 60 Query: 60 ATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEA 119 + + C +DAVL G++G P ++ E L LR+ +L+ +RP +LY + Sbjct: 61 SAYDACLASDAVLLGAMGLP---NVRYPNGKEIAPQLDLRERLQLYGGVRPIRLYHEADT 117 Query: 120 FCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIA 179 D + VRE T G+++G+ + ++A + R ER+ R+A Sbjct: 118 PL---KGHGPGEIDFVLVRESTEGLFYGRD--AIADLEADEATNLLRITRSASERVCRLA 172 Query: 180 FESARKR--RHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDP 237 FE+AR+R + VT IDKANVL S + +R + +E+A E+ D++ H+Y+D A + L++ P Sbjct: 173 FETARRRDGKKTVTLIDKANVLSSMVYFRHVFDEVAKEFLDIKAEHVYVDAAALFLVRRP 232 Query: 238 SQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIAN 297 FDV++ N+FGDILSD A + G MGM PS + + +++P+ GSAPDIAG++IAN Sbjct: 233 QDFDVMVTENMFGDILSDLAAGLVGGMGMAPSGDIGDD-AAVFQPSHGSAPDIAGQSIAN 291 Query: 298 PIAQILSLALLLRY--SLDADDAACAIERAINRALEEGI-RTGDLARGAAAVSTDEMGDI 354 PIA LS A++L + + AA A+ AI L + RT D+ +ST E+ D Sbjct: 292 PIAMHLSTAMMLEWLDHPETRRAADALNAAIADVLSDPTQRTADM---GGNLSTVEITDK 348 Query: 355 IARYVAEGV 363 IA +++ + Sbjct: 349 IAERLSKRL 357 >UniRef50_B0RIP4 3-isopropylmalate dehydrogenase n=140 Tax=Bacteria RepID=LEU3_CLAMS Length = 355 Score = 328 bits (842), Expect = 2e-88, Method: Composition-based stats. Identities = 133/366 (36%), Positives = 191/366 (52%), Gaps = 16/366 (4%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPA 60 M + +AV+PGDGIGPEV+ +AL+VL + + T+ Y G GQ L + Sbjct: 1 MPRTISLAVVPGDGIGPEVVHEALRVLREAV-PADVSLDTTQYPFGAGHFLETGQILTDS 59 Query: 61 TVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAF 120 + Q DA+L G+VGG + ERG LL LR F + NLRP L G+ + Sbjct: 60 DLAALAQHDAILLGAVGGDPRDARLAGGIIERGLLLKLRFAFDHYINLRPTALLPGVASP 119 Query: 121 CPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAF 180 A D + VRE T G Y G ++E A + V +ER R AF Sbjct: 120 L-----AAPGQVDFVVVREGTEGPYAGNGGVLRRGTEHEIATEVSVNTAHGVERTVRFAF 174 Query: 181 ESARKR-RHKVTSIDKANVLQSSI-LWREIVNEIATEYPDVELAHMYIDNATMQLIKDPS 238 E A KR R +VT + K NVL + LW+ V+ +A E+PDV + ++++D + L+ DPS Sbjct: 175 ELAEKRDRKRVTLVHKTNVLTFAGSLWQRTVDRVAAEHPDVTVDYLHVDATMIFLVTDPS 234 Query: 239 QFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQG--FGLYEPAGGSAPDIAGKNIA 296 +FDV++ NLFGDI++D A I+G +G+ S ++N G ++EP GSAPDIAG+ A Sbjct: 235 RFDVIVSDNLFGDIITDLAAAISGGIGLAASGNVNPTGAFPSMFEPVHGSAPDIAGQQKA 294 Query: 297 NPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIA 356 +P A ILS+ALLL + ++ AA + AA ST E+GD I Sbjct: 295 DPTAAILSVALLLDHLGLSEAAARVSAAVSDDLAARAT------GDAAPRSTAEVGDAIL 348 Query: 357 RYVAEG 362 R ++ Sbjct: 349 RALSTN 354 >UniRef50_UPI0001AF2578 isocitrate dehydrogenase [NADP] (oxalosuccinatedecarboxylase) (idh) (nadp(+)-specific icdh) n=1 Tax=Streptomyces roseosporus NRRL 15998 RepID=UPI0001AF2578 Length = 372 Score = 327 bits (839), Expect = 4e-88, Method: Composition-based stats. Identities = 91/378 (24%), Positives = 152/378 (40%), Gaps = 34/378 (8%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATV 62 + Y + ++PGDG GPE++ A VLD +I + G A+ LP AT+ Sbjct: 2 RTYEVTLVPGDGSGPELVDAARSVLDHAARLSGFKIDWDVHQAGQRALAESESLLPDATL 61 Query: 63 EGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 A L G P R + +R+ L++ LRP + Sbjct: 62 NSIRTNGAALKGPTTTPIGTG-------HRSVNITIRQELDLYACLRPVRSLP----IAS 110 Query: 123 LRADIAANGFDILCVRELTGGIYFGQP---------------KGREGSGQYEKAFDTEVY 167 + + D++ VRE T +Y G + A + + Sbjct: 111 TQEEPERPHVDLVVVRENTEDVYAGLEYPKGSPGARAVVQALGALGRPLPADTAVSLKPF 170 Query: 168 HRFEIERIARIAFESARKRRHKVT--SIDKANVLQSSILWREIVNEIATEYPDVELAHMY 225 ER+ AF A + K+ D + ++ + +++A +P + + Sbjct: 171 TPHGCERVVEFAFNHAARHGRKLVESVCDARRYPATEGMFARVASKVAARHPSIASRTVP 230 Query: 226 IDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGG 285 + L++ P + DVL+ NL+GDI+SD A + GS+G+ P A++ ++E G Sbjct: 231 VPALCADLVRAPGRHDVLVLPNLYGDIISDVTAALVGSLGVAPGANIGA-HHAVFEATHG 289 Query: 286 SAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEG-IRTGDL---AR 341 SAP+ AG NP A I S +LL + L + A I A+ + G + T DL R Sbjct: 290 SAPEFAGSGRLNPTALIFSGCMLLDH-LGEHETAARIRAAVEDVVAAGEVLTFDLLAPQR 348 Query: 342 GAAAVSTDEMGDIIARYV 359 A A +T E + + Sbjct: 349 SADAATTVEFTRAVTDRL 366 >UniRef50_C6V444 Isocitrate dehydrogenase n=2 Tax=Neorickettsia RepID=C6V444_NEORI Length = 471 Score = 327 bits (839), Expect = 4e-88, Method: Composition-based stats. Identities = 98/364 (26%), Positives = 170/364 (46%), Gaps = 33/364 (9%) Query: 5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHG-QPLPPATVE 63 + V GDG+GPE+MT L+++ I ++G + + + E Sbjct: 2 PKLTVAYGDGVGPEIMTSVLEIIFEA----GAEIQIDTIEIGQKIYEKGWPSGISDSGWE 57 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 ++ +L + P+ + R + LRK LF+N+RP K Sbjct: 58 TLKRNKVLLKAPITTPRGGGV-------RSLNVTLRKKLGLFANIRPCKS---------- 100 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 + DI+ +RE +Y G + + T+V ERI R AFE A Sbjct: 101 HLEWQDPKMDIVIIRENEEDLYSGIEYRQ----TLDTYNCTKVITESTSERICRYAFEYA 156 Query: 184 RKR-RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFD 241 R R KVT + K N+++ + ++ ++ ++A EYPD+E + ID ++ K+P +FD Sbjct: 157 RSNGRKKVTVMVKDNIMKLTDGIFHKLFKKVALEYPDIESENYIIDIGAARIAKNPEKFD 216 Query: 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQ 301 V++ NL+GDI+SD A I+GS+G+ S ++ E+ + ++E GSAPDIA ++IANP Sbjct: 217 VIVTLNLYGDIISDIAAEISGSVGLGGSINIGEE-YAMFEAVHGSAPDIADQDIANPSGL 275 Query: 302 ILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARG---AAAVSTDEMGDIIARY 358 + + +L Y + + A + A + L+ G+ T D+ V T + + I Sbjct: 276 LNAAMYMLSY-IGQKEIAQKVYSAWLKTLKSGVHTADIFNPLHSKLKVGTKKFTEHIIHN 334 Query: 359 VAEG 362 + Sbjct: 335 IDRK 338 >UniRef50_A7SJV9 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7SJV9_NEMVE Length = 394 Score = 327 bits (838), Expect = 5e-88, Method: Composition-based stats. Identities = 89/360 (24%), Positives = 163/360 (45%), Gaps = 29/360 (8%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPL--PPATVE 63 + ++PGDGIGPE++ + + + + ++ G I + L + Sbjct: 52 TVTLIPGDGIGPEMVVAVQDIFRHI----GVPVDFEELNLSGLDIKDEDSYLGAFNEAIT 107 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 ++ + G++ P R L LR H LF+N+ K G++ Sbjct: 108 SIKRNGVAMKGNIFTPLDA-----IPGFRSLNLELRVHLDLFANIVRCKSIPGIQT---- 158 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 N D++ +R+ T G Y E + +V +IA+ AF+ A Sbjct: 159 ----RHNNVDLVIIRQNTEGEYS----HLEHENVSGVIENLKVTTEEACMKIAQYAFDFA 210 Query: 184 RKR-RHKVTSIDKANVLQS-SILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFD 241 K R KVT++ KAN+++ L+ E++ YP++E M IDN MQL+ P QFD Sbjct: 211 EKHDRKKVTAVHKANIMKMGDGLFLRCCEEMSHSYPNIEFNSMIIDNCCMQLVAHPQQFD 270 Query: 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQ 301 V++ NL+G+I+S+ A + G G++P ++ + + DI GK+I+NPI+ Sbjct: 271 VMVLPNLYGNIVSNIGASLVGGPGIVPGENIGGDYAIFESGSRHTGLDIQGKDISNPISM 330 Query: 302 ILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYVAE 361 + + L+L + L+ A I AI + ++ G+ T D+ + +T + + + + Sbjct: 331 LFASTLMLEH-LEFTAYADLINSAILKVVQRGVLTADV---GGSHTTTQFLSALKSELDQ 386 >UniRef50_C4QCG1 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial, putative n=1 Tax=Schistosoma mansoni RepID=C4QCG1_SCHMA Length = 399 Score = 326 bits (835), Expect = 1e-87, Method: Composition-based stats. Identities = 91/363 (25%), Positives = 159/363 (43%), Gaps = 36/363 (9%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 + +A+L GDG+GPE+++ +V + I V + D + Sbjct: 68 RHTVAMLLGDGVGPELLSYVKEVFQVI----GAPIDFEEVAVNQESEDATFT----DALL 119 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 ++ + G+ + + LR + L++ ++ + + G+ Sbjct: 120 AMKRNGVGIKGNFATEPGQS---------SRNVALRLNLNLYAFVQRCRNFPGVVT---- 166 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 DI+ +RE T G Y E ++ R + RIA+ AF+ A Sbjct: 167 ----RHQNVDIVIIRENTEGEYS----RLEHENVPGVVESLKIITREKSTRIAQFAFDYA 218 Query: 184 -RKRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFD 241 R R KVT++ KAN+++ L+ ++ + IA YP +E HM IDN MQL+ P QFD Sbjct: 219 VRHNRKKVTAVHKANIMKLGDGLFLDVCSSIAKNYPQIEFNHMIIDNTCMQLVTKPQQFD 278 Query: 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQ 301 V++ NL+G+I+ + A + G G+ +L Q S +AGKNIANP Sbjct: 279 VIVLPNLYGNIVGNVAAGLVGGAGLTTGINLGPQNALFEMGTRNSGRSLAGKNIANPCGM 338 Query: 302 ILSLALLLRYSLDADDAACAIERAINRAL-EEGIRTGDLARGAAAVSTDEMGDIIARYVA 360 +L+ A +L Y L A I ++ + E+ IRT DL + T ++ + + + + Sbjct: 339 LLTSADMLEY-LGHIKEAKLIRDSVVDVIGEQKIRTADL---GGSFKTSKVIEAVLKSLR 394 Query: 361 EGV 363 + Sbjct: 395 NQL 397 >UniRef50_D2RVT1 Isocitrate dehydrogenase, NADP-dependent n=1 Tax=Haloterrigena turkmenica DSM 5511 RepID=D2RVT1_9EURY Length = 425 Score = 325 bits (834), Expect = 1e-87, Method: Composition-based stats. Identities = 105/410 (25%), Positives = 159/410 (38%), Gaps = 64/410 (15%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQP--LPP 59 N I ++ GDGIG +V A KVL+A I+ G +A + +G+ LP Sbjct: 28 PDNPIIPIIHGDGIGKDVGPAAQKVLEAAAEATGRDISWMRVYAGESAREEYGEDVNLPD 87 Query: 60 ATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEA 119 TV+ + + G + P R + LR+ L++N+RP G+ + Sbjct: 88 ETVDAIREHRVAIKGPLTTPVGAGF-------RSLNVALRQTLDLYANVRPTYYLDGVPS 140 Query: 120 FCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEK------------------- 160 A D++ RE T +Y G + Sbjct: 141 PMK-----APEEMDMVTFRENTEDVYAGIEWEAGTDEVEQVREFVEDEMGFDETMHDGPI 195 Query: 161 AFDTEVYHRFEIERIARIAFESARKR-RHKVTSIDKANVLQ-SSILWREIVNEIA-TEYP 217 + +R+ R A + A + R KVT + K N+++ + + + E+A EYP Sbjct: 196 GIGLKPITEKGSKRLVREAIDYALEHDRDKVTLVHKGNIMKFTEGQFGDWGMEVADEEYP 255 Query: 218 D-----------------------VELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILS 254 D V + D + +FD+L NL GD LS Sbjct: 256 DDEVFAAPDSLWETQDEVDIPEDAVMVEERLADAMLQWMQLRTDEFDILAMPNLNGDYLS 315 Query: 255 DECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLD 314 D G +G+ P + +G L EP GSAP AG+++ANP A ILS L+ Y L Sbjct: 316 DAAGAQIGGLGIAPGGNFG-KGRMLAEPVHGSAPKRAGQDMANPTAMILSGRLMFDY-LG 373 Query: 315 ADDAACAIERAINRALEEGIRTGDLAR---GAAAVSTDEMGDIIARYVAE 361 DDAA I A+ + G T DL R A + T E D I + + Sbjct: 374 WDDAADLIRDAVEETISSGKVTYDLERQLEDAEKLGTSEYTDEIVDTIEK 423 >UniRef50_C7RJH9 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Accumulibacter phosphatis clade IIA str. UW-1 RepID=C7RJH9_9PROT Length = 364 Score = 325 bits (834), Expect = 1e-87, Method: Composition-based stats. Identities = 125/377 (33%), Positives = 189/377 (50%), Gaps = 28/377 (7%) Query: 1 MSK--NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFA-MRITTSHYDVGGAAIDNHGQPL 57 M + +HIAVLPGDGIGPE++ +L VL+ + R + H + G A G Sbjct: 1 MKRDLRFHIAVLPGDGIGPEIVASSLHVLEVLNERMGGIGFDFWHLEGGAAHYQKTGTAF 60 Query: 58 PPATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGL 117 + C++ADAVL G++G P H+ E L LR L++ LRP + Y L Sbjct: 61 SDENMAACKKADAVLLGAIGLP---HVRYSDGTEVTTQLDLRVEMDLYAGLRPIRSYPSL 117 Query: 118 EAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIAR 177 + A+ D++ VRE T GI + + +G A++T + R R++ Sbjct: 118 PRVLVDK---RASQIDLVLVREQTEGILYSRCRG--TIEDDRVAWETMMISRNGTSRVSE 172 Query: 178 IAFESA------RKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATM 231 AF A R+R KV +D++N L S +R I E+A +P V + Y+D M Sbjct: 173 FAFRVAERRAKSRRRPGKVLCVDRSNALTSMAFFRRIFGEVAERHPSVSADYAYVDTTAM 232 Query: 232 QLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIA 291 +L+K P +FDVL+ N FG ILSD A + GS+G+ PSA + E+ +++PA GSAP IA Sbjct: 233 KLVKSPWEFDVLVTENAFGGILSDLAAGVVGSLGLAPSADIGEK-HAVFQPAHGSAPHIA 291 Query: 292 GKNIANPIAQILSLALLLRYSLDAD------DAACAIERAINRALEEGIRTGDLARGAAA 345 G+ +ANP+AQILS+AL+L + D A +E A+ +AL + Sbjct: 292 GQGLANPVAQILSVALMLDWLADQHGEPRLAHGARILEHAVEKALT--VVCP--VEFGGK 347 Query: 346 VSTDEMGDIIARYVAEG 362 T + I + + Sbjct: 348 DGTAAITKAIIAQIRKS 364 >UniRef50_O13696 Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial n=76 Tax=Fungi/Metazoa group RepID=IDH1_SCHPO Length = 356 Score = 323 bits (829), Expect = 5e-87, Method: Composition-based stats. Identities = 95/363 (26%), Positives = 152/363 (41%), Gaps = 32/363 (8%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGG--AAIDNHGQPLPPAT 61 Y + ++PGDGIG E ++ + I DV G + G L Sbjct: 20 KYTVTLIPGDGIGRETSNAVTEIFKTAN----VPIEFEEIDVTGMEKNNKSSGDALH-EA 74 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 ++ ++ L G + P ++ + LRK ++++L K G + Sbjct: 75 IQSLKRNKVGLKGILFTP------FEKGGHTSFNVALRKELDIYASLVLIKNIPGFKT-- 126 Query: 122 PLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFE 181 + D +RE T G Y G E ++ ++ +RIA+ AF+ Sbjct: 127 ------RHDNVDFAIIRENTEGEYSG----LEHQSVPGVVESLKIITEYKSKRIAQFAFD 176 Query: 182 SARKR-RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQ 239 A + R VT I KAN+++ + L+R ++A Y + + +DNA+MQ + P Q Sbjct: 177 FALQNGRKSVTCIHKANIMKLADGLFRRTFYDVANGYDAITPKDLIVDNASMQAVSRPQQ 236 Query: 240 FDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPI 299 FDVL+ NL+G ILS+ + + G G++P A+ I G+ ANP Sbjct: 237 FDVLVMPNLYGSILSNIGSALVGGPGVIPGANFGRDYALFEPGCRHVGLSITGRGEANPT 296 Query: 300 AQILSLALLLRYSLDADDAACAIERAINRALEEGI-RTGDLARGAAAVSTDEMGDIIARY 358 A ILS L+LR+ L D A I A +EEG T DL + ST + I Sbjct: 297 AAILSACLMLRH-LGLKDYADLINAATYSVIEEGKTLTKDL---GGSASTGDFTHAILER 352 Query: 359 VAE 361 + Sbjct: 353 MES 355 >UniRef50_B3RY01 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens RepID=B3RY01_TRIAD Length = 415 Score = 323 bits (828), Expect = 6e-87, Method: Composition-based stats. Identities = 94/359 (26%), Positives = 159/359 (44%), Gaps = 36/359 (10%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 Y + ++PGDGIGPE+ VL + ID + A + Sbjct: 87 RYTVTLIPGDGIGPEMARHVKTVLHKCGAPIDFEV-----------IDIKDESSTDAAII 135 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 ++ L G++ + +R+ L+SN+ P K G+ Sbjct: 136 SLKRNGIGLKGTITTNI------SNPQSQSINAQIRRKLDLYSNIVPCKSIPGVWT---- 185 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 D++ +RE T G Y E ++ + RIA+ AF+ A Sbjct: 186 ----RHGQVDLVVIRENTEGEY----GSLEHENVDGVVESLKIITEKKSRRIAKFAFDYA 237 Query: 184 RKR-RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFD 241 + R KVT+I KAN+++ + L+ E EI+ +Y D+E M IDN MQ++ +P QFD Sbjct: 238 LQNNRRKVTAIHKANIMKLADGLFLETCREISKDYTDIEFESMIIDNCCMQMVTNPQQFD 297 Query: 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQ 301 V++ NL+G+I+S + G +G++P ++ ++ A D+ G N ANP Sbjct: 298 VMVMPNLYGNIVSHIGIGLVGGIGLVPGKNIGDKYAIFESGARNIGSDLVGLNRANPCGF 357 Query: 302 ILSLALLLRYSLDADDAACAIERAINRALEEGI-RTGDLARGAAAVSTDEMGDIIARYV 359 + + AL+LR+ L DD A IE A+ ++ G RT D+ +T + D + + + Sbjct: 358 LFTSALMLRH-LGLDDYADIIESAVRTTIKNGKCRTPDIQGDR---TTADFIDAVIKEI 412 >UniRef50_A5FXZ9 3-isopropylmalate dehydrogenase n=2 Tax=Alphaproteobacteria RepID=A5FXZ9_ACICJ Length = 353 Score = 323 bits (828), Expect = 7e-87, Method: Composition-based stats. Identities = 117/368 (31%), Positives = 172/368 (46%), Gaps = 27/368 (7%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 I +L GD IG E++ +A++V+ A R + I +G AA+D+ G LP T+E Sbjct: 2 KIGILNGDDIGHEIVPEAVRVMQAAAARTGLAIEWQDIPIGRAALDSLGSTLPDGTIERL 61 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 + D L G +G + +P P LRKHF LF+N+RP K + L Sbjct: 62 DALDGWLLGPIGHMAYPKIPEAINPHP----LLRKHFDLFANIRPVKSHAALPCL----- 112 Query: 126 DIAANGFDILCVRELTGGIYFGQP---KGREGSGQYEKAFDTEVYHRFEIERIARIAFES 182 G D++ VRE G + E + V R ++AR AFE Sbjct: 113 ---HQGVDLVIVRENNEGFQPDRNVVAGSGEFRPTPDVTISVRVITRNGSSKVARAAFEL 169 Query: 183 ARKRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFD 241 AR RR +T++ K V + ++ E +A EYPDV +D M+L+ P ++D Sbjct: 170 ARARRRHLTAVHKDTVFKLGCGMFAEECRRLAAEYPDVTYDEAIVDTFAMRLVMTPQRYD 229 Query: 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQ 301 V++ +N+FGDIL+DE A + G +GM + + GSAPDIAG+ IANP A Sbjct: 230 VVVTTNMFGDILTDEAAGLVGGLGMAAGLCAGP-RHAMAQATHGSAPDIAGRGIANPYAM 288 Query: 302 ILSLALLLRYSLDAD------DAACAIERAINRALEE-GIRTGDLARGAAAVSTDEMGDI 354 I+S +LL + AA IE+A+ +EE T DL +T MG Sbjct: 289 IMSGQMLLDWLGRRHAEPAATAAARLIEQAVANMIEERRALTPDLGGQG---TTAGMGSA 345 Query: 355 IARYVAEG 362 I + E Sbjct: 346 IIEAMTES 353 >UniRef50_B7PN53 Isocitrate dehydrogenase, putative (Fragment) n=1 Tax=Ixodes scapularis RepID=B7PN53_IXOSC Length = 381 Score = 321 bits (824), Expect = 2e-86, Method: Composition-based stats. Identities = 90/362 (24%), Positives = 164/362 (45%), Gaps = 32/362 (8%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 + + +LPG GIGPE+M + + +VG A+ +H ++ Sbjct: 47 RFFVTLLPGHGIGPEMMRHVEAIFACGKVPVDFETIIVDANVGDASSMDH-------AIK 99 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 + L G++ + + L LR +L+ N+ + + G+ Sbjct: 100 SIRRNGVALKGNIETTSYSMTVEPR------NLLLRNKLELYVNVVHCRNHPGI------ 147 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 + G DI+ +R+ T G Y E ++ + +IA+ FE A Sbjct: 148 --NTKHKGVDIVVIRQNTEGEYS----CLEHEVTSGVVESLKIITWAKSFQIAKYCFEYA 201 Query: 184 RKR-RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFD 241 R R KVT + KAN+++ + L+ + E+A EYPD+EL + IDN MQL+ +P+QFD Sbjct: 202 RTHMRKKVTVVHKANIMKLTDGLFLKTCTEVAQEYPDIELNDIIIDNCCMQLVANPAQFD 261 Query: 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQ 301 V+L NL+G+I+ + + G G+ + ++ + + GKN+ANP+A Sbjct: 262 VMLVPNLYGNIVVNVACGLVGGAGVTSGRNYGKEYAVFETATRNTGTPLVGKNLANPVAT 321 Query: 302 ILSLALLLRYSLDADDAACAIERAINRAL-EEGIRTGDLARGAAAVSTDEMGDIIARYVA 360 + + +L++ L+ D A I RAI + + + + T DL +T ++ + I + V Sbjct: 322 LYAAVDMLKH-LELWDHAVVIRRAIEKTVNRDKVHTKDL---GGDATTSKVVENILKEVQ 377 Query: 361 EG 362 + Sbjct: 378 KN 379 >UniRef50_Q5P9Q1 Isocitrate dehydrogenase n=13 Tax=Rickettsiales RepID=Q5P9Q1_ANAMM Length = 488 Score = 319 bits (819), Expect = 7e-86, Method: Composition-based stats. Identities = 95/365 (26%), Positives = 162/365 (44%), Gaps = 32/365 (8%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQP-LPP 59 MS +A GDG+GPE+M L +L R ++ D+G + P Sbjct: 6 MSVPITVAY--GDGVGPEIMEAVLFILKEARA----DVSIETVDIGHNQYKKEWTSGIAP 59 Query: 60 ATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEA 119 + E + +L P+ + + LR+ L+ N+RP Y + Sbjct: 60 SAWESISRTRLLLKAPTMTPQGSG-------HKSLNVALRQRLGLYVNVRPCVSYFPVV- 111 Query: 120 FCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIA 179 D++ +RE Y G E + ++ R E+I A Sbjct: 112 ------GTKHPDLDVVIIRENEEDTYSG----VEHKLSEDTHECVKISTRSASEKICAYA 161 Query: 180 FESARK-RRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDP 237 F AR R KVT K N+++ + + +++A YPD+E + +D ++ +P Sbjct: 162 FNYARAHNRKKVTCFVKDNIMKMTDGILHASFDKVAKGYPDIEANYYIVDVGMAKIASNP 221 Query: 238 SQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIAN 297 FDV++ +NL+GDI+SD ++ +GS+G+ SA++ + + ++E GSAPDIAGKN+AN Sbjct: 222 EDFDVVVTTNLYGDIVSDIVSLSSGSIGLTGSANIGD-YYAMFEAVHGSAPDIAGKNVAN 280 Query: 298 PIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAV---STDEMGDI 354 P + + +L + D A I A + LE+G+ T D+ ++ ST E Sbjct: 281 PSGLLNAAVQMLVHIGQLDKAG-VIRNAFLKTLEDGVHTADIYSEKTSLRRASTMEFAQA 339 Query: 355 IARYV 359 I + Sbjct: 340 IVGNL 344 >UniRef50_Q05FQ8 3-isopropylmalate dehydrogenase n=1 Tax=Candidatus Carsonella ruddii PV RepID=Q05FQ8_CARRP Length = 349 Score = 319 bits (817), Expect = 1e-85, Method: Composition-based stats. Identities = 145/366 (39%), Positives = 215/366 (58%), Gaps = 25/366 (6%) Query: 5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEG 64 ++ +LPGDGIGPE++ Q +K++ + +I + +GG +ID P+ + Sbjct: 2 INLLILPGDGIGPEIIKQVIKIVKSC-IYTGYKINIIYNYIGGISIDKFNTPITNNLISI 60 Query: 65 CEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 + D + G VGG KW H +PE G LL LRK F F+N+RP K Sbjct: 61 IKYIDTIFLGCVGGYKWNHSIF--KPEYG-LLKLRKKFNFFTNIRPIK------------ 105 Query: 125 ADIAANGFDILCVRELTGGIYFGQPKGRE----GSGQYEKAFDTEVYHRFEIERIARIAF 180 DI+ VREL GGIY+G+PKG A++T++Y+ EI R+ARI+F Sbjct: 106 --CPFKNIDIIIVRELNGGIYYGKPKGFSKQIINQIPTWYAYNTKIYNEQEIIRLARISF 163 Query: 181 ESARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQF 240 A R+ K+ SIDK+NVL++ LW++ +N + Y V+L+H+YID AT+ LIK+ ++F Sbjct: 164 NLALNRKKKLCSIDKSNVLETFKLWKKTINYVHKFYNKVKLSHIYIDYATIDLIKNFNKF 223 Query: 241 DVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIA 300 DV++ SNLFGDI+SD C+++TGS+GMLPS S+N + L+EP GSAPDIA KNIANP+ Sbjct: 224 DVIITSNLFGDIISDLCSLLTGSLGMLPSISINNKSLSLFEPCHGSAPDIANKNIANPVG 283 Query: 301 QILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLA---RGAAAVSTDEMGDIIAR 357 +LSL ++ Y L+ + + +I + L G T D+ R VST+E GD++ Sbjct: 284 ALLSLVMMFEYVLNDFKLSNNLYYSIYKVLSYGFCTIDMKKYIRNFKIVSTEEFGDLVNH 343 Query: 358 YVAEGV 363 + V Sbjct: 344 FFIINV 349 >UniRef50_Q1IMD5 3-isopropylmalate dehydrogenase n=3 Tax=cellular organisms RepID=Q1IMD5_ACIBL Length = 403 Score = 319 bits (817), Expect = 1e-85, Method: Composition-based stats. Identities = 112/402 (27%), Positives = 185/402 (46%), Gaps = 48/402 (11%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 + +PGDGIG +V+ QA++VL+AV H D+G N G LP T++ Sbjct: 3 RPTVVTMPGDGIGNQVLPQAIRVLEAV----GFEANYVHADIGWECWCNEGNALPDRTIQ 58 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPE--------RGALLPLRKHFKLFSNLRPAKLYQ 115 + LFG++ + + +PE ++ +R+ F L +RP + Sbjct: 59 LLRKHKLGLFGAITSKPKKAADAELKPELRGKGLSYFSPIVTMRQLFNLDVCMRPCLSFP 118 Query: 116 GLEAFCPLRADI---AANGFDILCVRELTGGIYFGQPKGRE------------------G 154 G + D++ R+ T G+Y G Sbjct: 119 GNPLNFIRQTTCGGFEEPQVDVVVFRQNTEGLYAGVEWTNPPENVRTALASHKKFAAFAN 178 Query: 155 SGQYEKAFDTEVYHRFEIERIARIAFESARKRR-HKVTSIDKANVLQ-SSILWREIVNEI 212 + E A + + +RI AF+ A+K R VT +K NVL+ +S + E+ ++ Sbjct: 179 TPGEELAVSVRIITKKNAQRICEAAFKHAKKYRYKNVTICEKPNVLRETSGMMEEVAKQV 238 Query: 213 ATEYPDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASL 272 +YP++ L ID TM L K+P ++ V++ SNLFGD++SD A + G +G S ++ Sbjct: 239 QKQYPEIALWSTNIDAQTMWLTKNPEEYGVIVASNLFGDVISDAFAGLVGGLGFAASGNI 298 Query: 273 NEQGFGLYEPAGGSAPDIAGKN--IANPIAQILSLALLLRYSLDADDAACAIERAINRAL 330 ++ ++EP GSAP A N I NPIA ILS A++L + + + A I +AI + Sbjct: 299 GDE-VAVFEPTHGSAPKYAELNPSIVNPIAMILSAAMMLDH-IGESEKADRIRKAIADVV 356 Query: 331 EEG-IRTGDLARGA--------AAVSTDEMGDIIARYVAEGV 363 +EG +RT D+ R A A +T ++ D I +V + Sbjct: 357 KEGKVRTYDMMRIAGGPKSLAQGAANTVQITDAILVHVETAI 398 >UniRef50_D1B742 3-isopropylmalate dehydrogenase n=2 Tax=Synergistaceae RepID=D1B742_THEAS Length = 370 Score = 319 bits (817), Expect = 1e-85, Method: Composition-based stats. Identities = 120/385 (31%), Positives = 187/385 (48%), Gaps = 42/385 (10%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATV 62 K+Y I ++PGDGIGPEV QA+KV++A + F + +HY G + Q LP + Sbjct: 2 KSYRIGLIPGDGIGPEVTAQAVKVMEAAGSLFGFSLELTHYPYGAEHYLSTRQVLPDHAL 61 Query: 63 EGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 E E DA+L G++G P+ + ERG LL LR HF ++N+RP + + P Sbjct: 62 EEMEGLDALLLGAIGDPRVQ----PGILERGILLKLRFHFDQYANIRPVRSF----TPGP 113 Query: 123 LRADIAANGFDILCVRELTGGIYFGQPKGREGSGQY-----------------------E 159 L + + + +RE T +Y G +G+ Sbjct: 114 LGS------VNAVVIRENTEDLYVGIGSTGDGAVNLPLEVTRGGYVMKGQLSAFTTPPKR 167 Query: 160 KAFDTEVYHRFEIERIARIAFESARK-RRHKVTSIDKANVLQS-SILWREIVNEIATEYP 217 A + R + AF+ A +VT K+N ++ ++ +++A++Y Sbjct: 168 FAMQVAWHTLDGAARACQYAFDLALDLGAEEVTLATKSNAVRDLYGIFENACHQVASQYE 227 Query: 218 DVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGF 277 V L +D +L++ P F V+LC N+FGDI+SD A I G MG+ PS ++ + Sbjct: 228 SVSLRVENVDALCYKLVRSPGDFRVILCPNMFGDIVSDLLAGIGGGMGLAPSGNVGD-RL 286 Query: 278 GLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTG 337 ++EP GSAPDIAG++ ANP+A ILS A+LLR+ L AA A+E A+ R L + Sbjct: 287 SMFEPVHGSAPDIAGQDRANPVASILSGAMLLRH-LGETSAAKAMEDAVQRYLSGPVEEL 345 Query: 338 DLARGAAAVSTDEMGDIIARYVAEG 362 + + T GD + R + E Sbjct: 346 PIEM-GGRLGTRGAGDAVVRRLEES 369 >UniRef50_Q8XSY8 Probable 3-isopropylmalate dehydrogenase oxidoreductase protein n=2 Tax=Proteobacteria RepID=Q8XSY8_RALSO Length = 365 Score = 319 bits (817), Expect = 1e-85, Method: Composition-based stats. Identities = 110/366 (30%), Positives = 180/366 (49%), Gaps = 23/366 (6%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 I VLP DGIGPE++ A++VL + + F + + + DVG +++ +G L + Sbjct: 2 RILVLPCDGIGPEIVGAAMEVLRSADSVFKLDLAFDYDDVGFTSLEKYGTTLRDEVLAKA 61 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 + D V+ G P + R R L++N+RPA+ L + Sbjct: 62 KTYDGVILG---TQSHADYPAPDKGGRNVSAGFRIGLDLYANVRPARTRPFLTSNM---- 114 Query: 126 DIAANGFDILCVRELTGGIYFGQP---KGREGSGQYEKAFDTEVYHRFEIERIARIAFES 182 D++ +RE T G Y + E + A R ERIAR AFE Sbjct: 115 -REGRTMDLVIMREATEGFYPDRNMTKGWAELMPSPDMAISLRKITRHCSERIARRAFEL 173 Query: 183 ARKRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFD 241 A KR+ KVT+I KAN + L+ E V ++A ++P+V L + ID +T L++ P +FD Sbjct: 174 AMKRKKKVTAIHKANSFHMTDGLFLECVRDVARDFPEVRLDDLLIDASTAHLVRAPERFD 233 Query: 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQ 301 VL+ +N +GDI+SD + ++GS+G+ S ++ + GSAPDIAG++ ANP++ Sbjct: 234 VLVATNFYGDIISDLASELSGSLGLAGSMMASDT-HCCAQAQHGSAPDIAGQDKANPVSM 292 Query: 302 ILSLALLLRYSLDADDAACAI------ERAINRALEE-GIRTGDLARGAAAVSTDEMGDI 354 ILS+A+L+++ + + E A++ LE RT DL G + Sbjct: 293 ILSVAMLIQWMGEHHQNPAYLAAAQAMEAAVDSVLENPATRTPDL---GGNCGCKAFGQL 349 Query: 355 IARYVA 360 +A+ + Sbjct: 350 VAKVIQ 355 >UniRef50_Q0ZQ44 FrbE n=1 Tax=Streptomyces rubellomurinus RepID=Q0ZQ44_9ACTO Length = 365 Score = 318 bits (815), Expect = 2e-85, Method: Composition-based stats. Identities = 105/378 (27%), Positives = 166/378 (43%), Gaps = 37/378 (9%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATV 62 + + + ++ GDG GPE++ A VLD + G A+ + G+ LP +T+ Sbjct: 2 RKHTVTLIAGDGSGPELVAAARTVLDTAAGSAGFHLDWDVRPAGQGALRSVGELLPASTL 61 Query: 63 EGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 + + L G P R + +R+ L++ +RP +++ G Sbjct: 62 DSIRRNGVALKGPTTTPIG-------VGHRSVNITIRRELDLYACVRPVRVWPG------ 108 Query: 123 LRADIAANGFDILCVRELTGGIYFGQPKGREGSG--------------QYEKAFDTEVYH 168 A +G D++ VRE T +Y G + G AF + Sbjct: 109 --AGAVDSGIDVVVVRENTEDVYSGLEYPADSDGAAVVSATLSEFGHADPGIAFSLKPIT 166 Query: 169 RFEIERIARIAFESARK--RRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYI 226 RI A + ARK RR D ++ L+ E E+ EYPD+ A + + Sbjct: 167 PGGSRRIVAFALDHARKNGRRKVEVGADVYRYPRTEGLFFEAARELGPEYPDIVTATVPV 226 Query: 227 DNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGS 286 L++DP+ DVL+ NL+GD++SD A + G +GM P A++ + ++E GS Sbjct: 227 TVLCDSLVRDPADRDVLVLPNLYGDVISDVTAALVGGLGMAPGANIGD-RTAVFEATHGS 285 Query: 287 APDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEG-IRTGDLA---RG 342 AP+ AG N NP A ILS +LL + +A AA I A+ LEEG T DL R Sbjct: 286 APEFAGSNRLNPTALILSGCMLLDHLGEAPTAA-RIRAAVRSVLEEGRSVTFDLLPPDRA 344 Query: 343 AAAVSTDEMGDIIARYVA 360 A AV+T + + + Sbjct: 345 ARAVTTTAYAEAVIERLR 362 >UniRef50_C7P3E9 Isocitrate dehydrogenase, NADP-dependent n=5 Tax=Halobacteriaceae RepID=C7P3E9_HALMD Length = 425 Score = 318 bits (814), Expect = 3e-85, Method: Composition-based stats. Identities = 104/409 (25%), Positives = 160/409 (39%), Gaps = 62/409 (15%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPA 60 + +N + ++ GDGIG +V A KVL+A N I+ G +A + + + LP Sbjct: 29 IPENPIVPIIHGDGIGKDVGPAAQKVLEAAANATGREISWMRVFAGESAREKYDENLPDD 88 Query: 61 TVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAF 120 TV ++ + G + P R + LR+ +SN+RP G+ + Sbjct: 89 TVNAIDEHRVAIKGPLTTPVGAGF-------RSLNVALRQTLDFYSNVRPTYYLDGVPSP 141 Query: 121 CPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEK-------------------A 161 A D++ RE T +Y G + Sbjct: 142 MK-----APEEMDMVTFRENTEDVYAGIEWEAGTEEVEQVREFVEEDMGFDDVMHDGPIG 196 Query: 162 FDTEVYHRFEIERIARIAFESARKR-RHKVTSIDKANVLQ-SSILWREIVNEIA-TEYPD 218 + F +R+ R A + A + R KVT + K N+++ + + E E+A EYPD Sbjct: 197 IGIKPITEFGSKRLVRKAIDYAIEHDRDKVTLVGKGNIMKFTEGQFTEWGMEVADEEYPD 256 Query: 219 -----------------------VELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSD 255 V + D + +F VL NL GD LSD Sbjct: 257 DEVFAAPDSLWETQDEIDIPEDAVMVESRLADAMLQWMQLRTDEFSVLAMPNLNGDYLSD 316 Query: 256 ECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDA 315 G +G+ P A+ + L EP GSAP AG+N+ANP A ILS L+ Y + Sbjct: 317 AAGAQIGGLGIAPGANFGDAR-VLAEPVHGSAPKRAGQNMANPTAMILSGRLMFDY-MGW 374 Query: 316 DDAACAIERAINRALEEGIRTGDLAR---GAAAVSTDEMGDIIARYVAE 361 DAA + A+ + G T DL R A + T+E D I + + Sbjct: 375 KDAADLVRDAVEETISSGTVTYDLERQLEDAEKLGTEEYSDAIVENIEK 423 >UniRef50_C7MQT6 Isocitrate/isopropylmalate dehydrogenase n=1 Tax=Saccharomonospora viridis DSM 43017 RepID=C7MQT6_SACVD Length = 356 Score = 318 bits (814), Expect = 3e-85, Method: Composition-based stats. Identities = 117/366 (31%), Positives = 177/366 (48%), Gaps = 26/366 (7%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHY--DVGGAAIDNHGQPLPPATVE 63 I ++ GDGIGPE++ ++VLDA+ + D G G A V Sbjct: 5 RIGLIRGDGIGPEIVEATVRVLDALAELHPESRGWEYVEIDAGADTYRRTGVACAEADVR 64 Query: 64 GCE-QADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 + DA L G VG P PD LR ++N+RP + + G+ + Sbjct: 65 RLRDEVDATLKGPVGLPDV--RTPDGVEAGVLGGILRTGLDTYANIRPVRSWPGVPSR-- 120 Query: 123 LRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFES 182 + A+ D + VRE T G+Y + K G G DT + R R+AR AF Sbjct: 121 ----VRADRVDYVIVRENTEGLYASRGK---GVGNRWAVTDTLLTTREGTLRVARKAFTL 173 Query: 183 ARKRR-------HKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIK 235 A R+ +VT +DK+NVL+S +RE+V E+A E+P+VEL + Y D A L+ Sbjct: 174 AAGRQGAPADGVRRVTCVDKSNVLRSHAFFREVVTEVAAEFPEVELEYRYADAAAQDLVL 233 Query: 236 DPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNI 295 P +FDVL+ N GD+LSD G +G+ P+ ++ + G +EP GSAPD+ G+N Sbjct: 234 CPERFDVLVMENFLGDVLSDLGGATVGGVGLCPAGNVGD-GAAYFEPVHGSAPDLVGRNR 292 Query: 296 ANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDE-MGDI 354 ANP+ Q+L+ A+LL + L D A + RA++ L G T + + E + D Sbjct: 293 ANPVGQLLAAAMLLDH-LGHVDEAARLRRAVSAVLAFG--TVRIEADGTVLGGAEAVADA 349 Query: 355 IARYVA 360 + + Sbjct: 350 VIAALQ 355 >UniRef50_C0WN79 Isocitrate dehydrogenase [NADP] n=4 Tax=Lactobacillus RepID=C0WN79_LACBU Length = 429 Score = 318 bits (814), Expect = 3e-85, Method: Composition-based stats. Identities = 100/419 (23%), Positives = 159/419 (37%), Gaps = 72/419 (17%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFA---MRITTSHYDVGGAAIDNHGQPLP 58 N I + GDGIGPE+ A V DA + ++ G A GQ LP Sbjct: 16 PNNPTIPFIEGDGIGPEIWKAAKTVFDAAVKKAYDGQKQVNWLPLLAGETAYKKTGQWLP 75 Query: 59 PATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLE 118 T+ + + G + P R + LR+ L++ RP Y G Sbjct: 76 DKTLATLREYLVGIKGPLTTPIG-------IGHRSINVTLRQKLDLYACFRPVTYYPGTP 128 Query: 119 AFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYE------------------- 159 + + +I RE T IY G + E Sbjct: 129 SPV-----VHPENVNIDVFRENTEDIYAGIESDVDTKDAEEWKSLLAKQDKLSKVRFPDT 183 Query: 160 KAFDTEVYHRFEIERIARIAFESA-RKRRHKVTSIDKANVLQ-SSILWREIVNEIATEYP 217 AF + + R+ A + A RH +T + K N+++ + +++ E A +Y Sbjct: 184 SAFAIKPISKQGSTRLVDAAIDYAFANNRHTLTLVHKGNIMKKTEGGFKKWGYEAAEKYG 243 Query: 218 D--------------------------------VELAHMYIDNATMQLIKDPSQFDVLLC 245 D + + + DN Q + P F+V+ Sbjct: 244 DKVFTWNQYNQIKADQGEKAADQAYQTARDEQKLIVNDVITDNFFQQALLHPEHFEVVAT 303 Query: 246 SNLFGDILSDECAMITGSMGMLPSASLN-EQGFGLYEPAGGSAPDIAGKNIANPIAQILS 304 NL GD +SD A G +G+ P ++N + G ++E G+AP AG+N NP + ILS Sbjct: 304 MNLNGDYISDALAAQVGGIGIAPGGNINYQTGHAIFEATHGTAPQFAGQNKLNPTSIILS 363 Query: 305 LALLLRYSLDADDAACAIERAINRALEEGIRTGDLAR--GAAAVSTDEMGDIIARYVAE 361 A++ Y L DD + I I RA++ T D A+ A +ST G+ +A+ + E Sbjct: 364 GAMMFDY-LGWDDVSNLIRIGIKRAIKSHHVTVDFAKTPDATVLSTSGFGEYVAQLIEE 421 >UniRef50_B8NJA6 3-isopropymalate dehydrogenase, putative n=3 Tax=cellular organisms RepID=B8NJA6_ASPFN Length = 350 Score = 316 bits (811), Expect = 6e-85, Method: Composition-based stats. Identities = 109/364 (29%), Positives = 167/364 (45%), Gaps = 29/364 (7%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 I VL G+GIGPE+ ++V++A ++ + A+ +G LPP ++ Sbjct: 2 RIGVLKGNGIGPEITAATIRVIEA----TGIQPEWDFIPIADEAVRLYGHALPPQVIQRI 57 Query: 66 EQADAVLFGSVGGPKWEH------LPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEA 119 + + + K +R+ LF N RP + Y G+ Sbjct: 58 KDVKFCIKAPLLAEKLHGRISCTQTDGSVVTYPSINNAIRRELNLFVNPRPIRGYVGISG 117 Query: 120 FCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIA 179 D++ +RE+T Y G K E E + R ++++ A Sbjct: 118 --------RHEKMDMVIMREITEDTYIGWEKPLEDGAAAEA---IKRVTRSASWKVSQYA 166 Query: 180 FESARKR-RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDP 237 FE ARK R KV+ + KANVL + L+ E+A YPD+ M ID A +++DP Sbjct: 167 FEYARKHGRKKVSCLHKANVLHETDGLFLRTFQEVARLYPDIVGDDMMIDAACYSVVRDP 226 Query: 238 SQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIAN 297 FDV++ N +GDI SD A + GS+G+ P A++ + +E A G+APDIAG AN Sbjct: 227 CWFDVVVTVNQYGDIFSDLAAGLAGSLGLAPGANIGDS-ASTFEAAHGAAPDIAGTGAAN 285 Query: 298 PIAQILSLALLLRYSLDADDAACAIERAINRALEEG-IRTGDLARGAAAVSTDEMGDIIA 356 PIA ILS A LL + + AI A+ R +E G T DL +T+++ D I+ Sbjct: 286 PIALILSGAELLAH-AGYGKGSEAIREAVTRVIEAGRTLTPDL---GGRSTTEQVADAIS 341 Query: 357 RYVA 360 V Sbjct: 342 VEVR 345 >UniRef50_Q6GG12 Isocitrate dehydrogenase [NADP] n=90 Tax=root RepID=IDH_STAAR Length = 422 Score = 316 bits (811), Expect = 6e-85, Method: Composition-based stats. Identities = 97/420 (23%), Positives = 161/420 (38%), Gaps = 74/420 (17%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRF---AMRITTSHYDVGGAAIDNHGQPLP 58 I + GDGIGP++ A +V+DA + RI G A D G+ LP Sbjct: 16 PNEPIIPFIIGDGIGPDIWKAASRVIDAAVEKAYNGEKRIEWKEVLAGQKAFDTTGEWLP 75 Query: 59 PATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLE 118 T++ ++ + G + P + R + LR+ LF+ LRP + ++G+ Sbjct: 76 QETLDTIKEYLIAVKGPLTTPIGGGI-------RSLNVALRQELDLFTCLRPVRWFKGVP 128 Query: 119 AFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEK------------------ 160 + D++ RE T IY G + + Sbjct: 129 SPVK-----RPQDVDMVIFRENTEDIYAGIEFKEGTTEVKKVIDFLQNEMGATNIRFPET 183 Query: 161 -AFDTEVYHRFEIERIARIAFESAR-KRRHKVTSIDKANVLQ-SSILWREI--------- 208 + + ER+ R A + A R VT + K N+++ + +++ Sbjct: 184 SGIGIKPVSKEGTERLVRAAIQYAIDNNRKSVTLVHKGNIMKFTEGSFKQWGYDLALTEF 243 Query: 209 ------------------------VNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLL 244 E A + + + D Q++ P++ DV+ Sbjct: 244 GDQVFTWQQYDEIVEKEGRDAANVAQEKAEKEGKIIIKDSIADIFLQQILTRPAEHDVVA 303 Query: 245 CSNLFGDILSDECAMITGSMGMLPSASLN-EQGFGLYEPAGGSAPDIAGKNIANPIAQIL 303 NL GD +SD A G +G+ P A++N E G ++E G+AP AG N NP + IL Sbjct: 304 TMNLNGDYISDALAAQVGGIGIAPGANINYETGHAIFEATHGTAPKYAGLNKVNPSSVIL 363 Query: 304 SLALLLRYSLDADDAACAIERAINRALEEGIRTGD---LARGAAAVSTDEMGDIIARYVA 360 S L+L + L +AA I +I + + T D L GA VST D + + + Sbjct: 364 SSVLMLEH-LGWQEAADKITDSIEDTIASKVVTYDFARLMDGAEEVSTSAFADELIKNLK 422 >UniRef50_B8M3W0 3-isopropylmalate dehydrogenase n=6 Tax=Leotiomyceta RepID=B8M3W0_TALSN Length = 378 Score = 316 bits (810), Expect = 8e-85, Method: Composition-based stats. Identities = 147/381 (38%), Positives = 203/381 (53%), Gaps = 41/381 (10%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRN-RFAMRITTSHYDVGGAAIDNHGQPLPP 59 M++ + VLPGD IGPE++ +ALK+L + ++ S+ +GGA++D G + Sbjct: 1 MAEIRKLLVLPGDHIGPEIIAEALKILAVLEEELPNFKVQISYGLIGGASLDKTGSAITD 60 Query: 60 ATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEA 119 +E +DAVL GSVGGP+W H+P PE+G +L LR+ F+N+RP + Y Sbjct: 61 EVLETAVASDAVLLGSVGGPEWAHVPGALSPEKG-ILHLRQRLDAFANIRPCRFYASSLL 119 Query: 120 FCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIA 179 A G D + VRE GG YFG E R E+ER AR++ Sbjct: 120 NQSPLKPEIAAGVDFVLVRENCGGAYFGTKTEFEDEA------------RTEVERCARVS 167 Query: 180 FESAR--KRRHK--------VTSIDKANVLQSSILWREIVNEI-ATEYPDVELAHMYIDN 228 AR R V + DKANVL S WR + ++I E+PD+EL D+ Sbjct: 168 AALARTFGRGKNTDDKSPAIVWNADKANVLASGRFWRTVTHDIFEREFPDIELHDQLADS 227 Query: 229 ATMQLIKDPSQFD-VLLCSNLFGDILSDECAMITGSMGMLPSASL----NEQGF--GLYE 281 M ++K P++F+ V+ N FGDILSD I GS+G+LPSAS+ + G+YE Sbjct: 228 MAMVMVKAPTKFNGVIHTDNTFGDILSDISGGIVGSLGVLPSASVCGVPGSEKPVKGIYE 287 Query: 282 PAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEE------GIR 335 GSAPDI+G ANPIAQILSLA+LLRYS A +E A+ + LE GIR Sbjct: 288 AVHGSAPDISGTGQANPIAQILSLAMLLRYSFSMPRQADLLEDAVRKTLEVREHGGLGIR 347 Query: 336 TGDLARGAAAVSTDEMGDIIA 356 T DL + ST ++GD +A Sbjct: 348 TKDL---GGSASTQDVGDAVA 365 >UniRef50_A9UQS3 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9UQS3_MONBE Length = 378 Score = 316 bits (809), Expect = 1e-84, Method: Composition-based stats. Identities = 100/369 (27%), Positives = 176/369 (47%), Gaps = 32/369 (8%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPAT 61 ++ + + GDGIG E+++ A + ++A + I D+G A+ N G + + Sbjct: 31 TQAHTVLTFDGDGIGREIVSAAKECIEA----TGVNIRWEQMDMGYEAMQNTGVYIDDSH 86 Query: 62 VEGCEQADAVLFGSVGGPKWE---HLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLE 118 ++ E+ + G + P + ++ + RK+F+LF+N+RP + G+ Sbjct: 87 MDAFEEIGVLFKGPLTVPPKDTNAYVEVRGKRYTSGNQVFRKYFQLFANVRPVRSMPGVR 146 Query: 119 AFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARI 178 A N D++ +RE T +Y G+ + + + R ER+A Sbjct: 147 AP--------FNDVDLVVIRENTEDVYTGEETWVD----ADTVHCVKRISRGASERVADF 194 Query: 179 AFESARKR-RHKVTSIDKANVLQ-SSILWREIVNEIAT--EYPDVELAHMYIDNATMQLI 234 +F+ AR R +VT++ KANV + S L+ +E A + + D+ +L+ Sbjct: 195 SFKYARDNQRKRVTALHKANVCKQSDGLFLNTFHERAAATDLGGIIADDQLADSCLTKLM 254 Query: 235 KDPSQFDVLLCSNLFGDILSDECA----MITGSMGMLPSASLNEQGFGLYEPAGGSAPDI 290 +P FDVL C NL+GD+++ + GS+G+ PS ++ L+EPA GSAPDI Sbjct: 255 IEPKSFDVLCCPNLYGDLVNPLSLRINRGMVGSLGLCPSGNIG-THQALFEPAHGSAPDI 313 Query: 291 AGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDE 350 AGK IANP +QILS ++L + L +A+ +E A+ GI D T E Sbjct: 314 AGKGIANPTSQILSGCMMLSH-LGEFEASQRLENALRAMYASGIVPVDF---GGQADTKE 369 Query: 351 MGDIIARYV 359 + + +++ Sbjct: 370 VVAAVLKHL 378 >UniRef50_Q5JFV8 Homoisocitrate dehydrogenase n=4 Tax=Thermococcaceae RepID=Q5JFV8_PYRKO Length = 347 Score = 314 bits (806), Expect = 2e-84, Method: Composition-based stats. Identities = 130/356 (36%), Positives = 182/356 (51%), Gaps = 37/356 (10%) Query: 5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEG 64 Y +AV+PGDGIGPEV+ A++VL AV R + +Y+ G G P+ +E Sbjct: 2 YRVAVIPGDGIGPEVIDGAVRVLKAVTGR----VRFEYYEGGVDVFQECGSPIREEDLEE 57 Query: 65 CEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 ++DAVLFG+ P D R +L LRK L++NLR + L Sbjct: 58 IRRSDAVLFGATTTP------FDLPGYRSLILTLRKELGLYANLR---IIPDLRT----- 103 Query: 125 ADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESAR 184 G +I+ VRE + G+YFG G +A D + R ERIAR A E A+ Sbjct: 104 ------GREIVIVRENSEGLYFGIGAVVNG-----RAVDVRLITREGAERIARFAVEQAK 152 Query: 185 KRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLL 244 R +T + KANVL +R IV E+A E VE+ ID+ T++L+++P + V+L Sbjct: 153 ARGSFITFVHKANVLTGDKFFRRIVREVAGE-EGVEVRDAIIDSFTIKLVRNPWEHGVIL 211 Query: 245 CSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILS 304 NLFGDILSD + GS+G++PS + + G L+EP GSAPDIAGK IANPI ILS Sbjct: 212 SENLFGDILSDLATVHAGSIGIVPSGNYGD-GIALFEPVHGSAPDIAGKGIANPIGAILS 270 Query: 305 LALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYVA 360 A+LL Y I A+ + G T D+ T+++ I + Sbjct: 271 GAMLLDYLGL---DGSLIRAAVRGYVVNGELTPDM---GGRARTEDVVRGIIGEIE 320 >UniRef50_Q4ZRW7 3-isopropylmalate dehydrogenase n=13 Tax=Proteobacteria RepID=Q4ZRW7_PSEU2 Length = 396 Score = 314 bits (805), Expect = 3e-84, Method: Composition-based stats. Identities = 113/387 (29%), Positives = 170/387 (43%), Gaps = 50/387 (12%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 I VLPGDGIG EVM AL V+ A+ + D+G G+ +P T E Sbjct: 7 RKRICVLPGDGIGIEVMEAALPVIAALN----LPFDLVPADIGWQCWRAEGETVPARTWE 62 Query: 64 GCEQADAVLFGSVGGPKWEHLPPD--------QQPERGALLPLRKHFKLFSNLRPAKLYQ 115 DA L G++ + + ++ LR++ L++N+RP Sbjct: 63 IMASCDATLLGAITSKPLAEAEAELPLTLQGQNRRYVSPVIQLRQNLDLYANVRPVTDMT 122 Query: 116 GLEAFCPLRADIAANGFDILCVRELTGGIYFGQPKG-------------------REGSG 156 G N F + +RE T G+Y G G + G Sbjct: 123 G------------ENRFRFVVIRENTEGLYAGLDFGCIPDALVPLLEEREALGAAWQREG 170 Query: 157 QYEKAFDTEVYHRFEIERIARIAFESARKRR-HKVTSIDKANVLQSSILW-REIVNEIAT 214 Q + + R + RI AFE ARK +VT +DK VL+ S + R I A Sbjct: 171 QDDATVTLRLQTRSGLMRIFEYAFEYARKNHFTRVTFVDKPMVLRHSSAFARGIFEATAQ 230 Query: 215 EYPDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNE 274 YPDV +D + +++ P +F V++ N+FGDILSD A + G +G PS + Sbjct: 231 RYPDVSGVIENVDAVALWMVQRPERFGVIVAENMFGDILSDLGAGVMGGLGFAPSGNFGN 290 Query: 275 QGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGI 334 G +EP GSAP AG N ANP A +++AL+L + ++AC I +A++ Sbjct: 291 SG-AYFEPVHGSAPAHAGLNKANPGAMFMAIALMLEHLGFPTESAC-ISQAVSLVSRTST 348 Query: 335 RTGDLARGAAAVSTDEMGDIIARYVAE 361 RT DL + +T ++G+ I + E Sbjct: 349 RTYDL---GGSHTTAQVGEAIVQQCIE 372 >UniRef50_P28834 Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial n=7 Tax=Fungi/Metazoa group RepID=IDH1_YEAST Length = 360 Score = 313 bits (803), Expect = 5e-84, Method: Composition-based stats. Identities = 99/360 (27%), Positives = 168/360 (46%), Gaps = 34/360 (9%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 + + ++PGDG+G E+ + +A + I ++ G VE Sbjct: 28 RFTVTLIPGDGVGKEITDSVRTIFEA----ENIPIDWETINI-KQTDHKEGVY---EAVE 79 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 ++ L G H P DQ + LRK +++N+ K +G++ P Sbjct: 80 SLKRNKIGLKG------LWHTPADQTGHGSLNVALRKQLDIYANVALFKSLKGVKTRIP- 132 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 D++ +RE T G + G E +V R + ERIAR AF+ A Sbjct: 133 -------DIDLIVIRENTEGEFSG----LEHESVPGVVESLKVMTRPKTERIARFAFDFA 181 Query: 184 RK-RRHKVTSIDKANVLQ-SSILWREIVNEIA-TEYPDVELAHMYIDNATMQLIKDPSQF 240 +K R VT++ KAN+++ L+R I+ EI EYPD++++ + +DNA+MQ + P QF Sbjct: 182 KKYNRKSVTAVHKANIMKLGDGLFRNIITEIGQKEYPDIDVSSIIVDNASMQAVAKPHQF 241 Query: 241 DVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIA 300 DVL+ +++G IL + A + G G++ A+ + DI G+N+ANP A Sbjct: 242 DVLVTPSMYGTILGNIGAALIGGPGLVAGANFGRDYAVFEPGSRHVGLDIKGQNVANPTA 301 Query: 301 QILSLALLLRYSLDADDAACAIERAINRALEEGIR-TGDLARGAAAVSTDEMGDIIARYV 359 ILS L+L + L ++ A I +A++ + EG T D+ + ST + + I + Sbjct: 302 MILSSTLMLNH-LGLNEYATRISKAVHETIAEGKHTTRDI---GGSSSTTDFTNEIINKL 357 >UniRef50_A1WHK9 3-isopropylmalate dehydrogenase n=5 Tax=Proteobacteria RepID=A1WHK9_VEREI Length = 356 Score = 313 bits (803), Expect = 5e-84, Method: Composition-based stats. Identities = 118/367 (32%), Positives = 180/367 (49%), Gaps = 25/367 (6%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 I VLPGDGIGPE+M A++VL+A RF + + H G A++ HG + PA +E Sbjct: 2 KIVVLPGDGIGPEIMAVAVRVLEAASKRFQLDLEIGHDIAGHASLQRHGATVTPALLEKV 61 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 + AD ++ G + + + E RK L++N+RPA+ + G+ Sbjct: 62 KAADGLMLGPMATYD---FKDEAKGEINPSKFFRKELDLYANIRPARTFPGMAH------ 112 Query: 126 DIAANGFDILCVRELTGGIYFGQP---KGREGSGQYEKAFDTEVYHRFEIERIARIAFES 182 F++ VRE T G Y + E + R ERIAR AF+ Sbjct: 113 --RVGEFNLAVVRENTEGFYADRNIESGSSEMLITPDTVISLRRITRLCCERIARSAFDL 170 Query: 183 ARKRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFD 241 AR R V+ + KANVL+ ++ +I ++A E+P V + +D +++ P +FD Sbjct: 171 ARTRARHVSIVHKANVLKIGDGMFVDICRQVAREFPQVRVDDFIVDAMMAHVVRAPQRFD 230 Query: 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQ 301 V++ +N+FGDILSD A ++GS+G+ S + + + + GSAPDIAG+NIANP + Sbjct: 231 VIVTTNMFGDILSDLTAELSGSLGLGGSLNAGKD-HAMGQAVHGSAPDIAGRNIANPYSL 289 Query: 302 ILSLALLLRYSLDADD------AACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDII 355 ILS LL + + AA AI+ AL+ T D + T E G Sbjct: 290 ILSAGQLLGWHGQRKNLPAFALAARAIDETATAALQAREGTRD---AGGELGTAEAGQSF 346 Query: 356 ARYVAEG 362 R + EG Sbjct: 347 VRRLLEG 353 >UniRef50_A9FME3 3-isopropylmalate dehydrogenase n=7 Tax=Proteobacteria RepID=A9FME3_SORC5 Length = 363 Score = 313 bits (802), Expect = 7e-84, Method: Composition-based stats. Identities = 110/353 (31%), Positives = 179/353 (50%), Gaps = 17/353 (4%) Query: 17 PEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC-EQADAVLFGS 75 P V+ +A +L+ + R + I D+G G P + AVL G+ Sbjct: 19 PSVIAEAKLLLELYQERAGLPIDLWELDLGADRYLRDGTTFPNQIQIAIQRECSAVLLGA 78 Query: 76 VGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRADIAANGFDIL 135 +G P+ P+ + R L +R + L++N+RP + L A D + Sbjct: 79 LGDPR----VPNLEHARDILFGMRFGYDLYANVRPVR---ALSDRLVPLKGRTAKDIDFV 131 Query: 136 CVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARKR-RHKVTSID 194 RE T GIY G + E A + +V R +ERI R AF+ AR R +VT D Sbjct: 132 VFRENTEGIYVGMGGQFKRGTPDEVAINEDVNTRKGVERIIRAAFDYARANGRTRVTMAD 191 Query: 195 KANVL-QSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDIL 253 K+N + + LW + +E+ +YP+++ H+Y+D + +I+DP QF V++ +NLFGDI+ Sbjct: 192 KSNAMRHAHELWLRVFHEVRAQYPEIQSNHVYVDALCLYVIQDPGQFQVIVTNNLFGDIV 251 Query: 254 SDECAMITGSMGMLPSASL---NEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLR 310 +D A + G +GM SA++ + L+EP GSAP +AGK+IANP A +L+ LLL Sbjct: 252 TDLGAALQGGLGMAASANVHASDPARVALFEPVHGSAPPLAGKDIANPFAAMLTAGLLLA 311 Query: 311 YSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYVAEGV 363 + L + IER +++AL++G+ T D+ + T G + +A + Sbjct: 312 H-LGWPEEERRIERWVSQALDQGMCTVDV---GGTLGTRAAGAWVREQIAAEL 360 >UniRef50_P96318 Isocitrate dehydrogenase [NADP] n=5 Tax=cellular organisms RepID=IDH_CALNO Length = 429 Score = 312 bits (799), Expect = 1e-83, Method: Composition-based stats. Identities = 105/404 (25%), Positives = 161/404 (39%), Gaps = 59/404 (14%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFA---MRITTSHYDVGGAAIDNHGQPLP 58 N +A GDGIGPE++ A KVLDA ++ RI G A G LP Sbjct: 30 PDNLIVAYFKGDGIGPEIVESAKKVLDAAVDKAYGGTRRIVWWEVTAGEEAQKECGSLLP 89 Query: 59 PATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLE 118 T++ + A L G + P R + LR L+SN+RP K Y G Sbjct: 90 DGTLQAFKLARVNLKGPLTTPVGGGF-------RSLNVTLRMVLDLYSNVRPVKWY-GQP 141 Query: 119 AFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSG----------------QYEKAF 162 D + RE T +Y G + + Sbjct: 142 TP-----HCHPENIDWVIFRENTEDVYAGIEWPFDSPEAQKIRDFLKKEFGIELTPDTGI 196 Query: 163 DTEVYHRFEIERIARIAFESARKRR-HKVTSIDKANVLQ-SSILWREIV----------- 209 + ++ +R R A E A + VT + K N+++ + +R+ Sbjct: 197 GIKPISKWRTQRHVRRAMEWAIRNGYKHVTIMHKGNIMKYTEGAFRQWAYDLILSEFRDY 256 Query: 210 ----NEIATEYPD------VELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAM 259 E+ T+Y + + DN Q+I P +++V++ NL GD +SDE Sbjct: 257 VVTEEEVNTKYGGKAPEGKIIVNDRIADNMLQQIITRPGEYNVIVTPNLNGDYISDEANA 316 Query: 260 ITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAA 319 + G +GM + + G + EP GSAP AGKN+ NP A+ILS LL + + Sbjct: 317 LVGGIGMAAGLDMGD-GIAVAEPVHGSAPKYAGKNVINPTAEILSGMYLLSDFVGWPEVK 375 Query: 320 CAIERAINRALEEGIRTGDLA---RGAAAVSTDEMGDIIARYVA 360 +E A+ +A+ T DLA G +ST E D++ Y+ Sbjct: 376 LLVEYAVKQAIAHKQVTYDLAREMGGVTPISTTEYTDVLVDYIR 419 >UniRef50_Q48806 Protein dlpA n=5 Tax=Legionella RepID=DLPA_LEGPH Length = 615 Score = 311 bits (798), Expect = 2e-83, Method: Composition-based stats. Identities = 103/385 (26%), Positives = 170/385 (44%), Gaps = 47/385 (12%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPAT 61 + IAVLPGDGIG EV L V + + + + ++ D+G G +P T Sbjct: 4 TDPIKIAVLPGDGIGIEVTEATLPVFEVL----DVPVILNYGDIGWEFWKKEGAAIPSRT 59 Query: 62 VEGCEQADAVLFGSVGGPKWEH--------LPPDQQPERGALLPLRKHFKLFSNLRPAKL 113 + +D VL G++ L ++ LR+ LF+N+RP Sbjct: 60 WQLIASSDTVLLGAITSKPQREAKQELSNALKKSNPYYVSPVIQLRQGLDLFANVRPCFS 119 Query: 114 YQGLEAFCPLRADIAANGFDILCVRELTGGIYFG---------------QPKGREGSGQY 158 F+ +RE + G+Y G + + + Sbjct: 120 IDDQSKP-----------FNFCIIRENSEGLYCGFDYFPLPKAIHSLLAESQHWQTIPAD 168 Query: 159 EKAFDTEVYHRFEIERIARIAFESARKRR-HKVTSIDKANVLQSSILW-REIVNEIATEY 216 E + + + + R+ AF+ A + +VT DK NVL+ S + R+I A Y Sbjct: 169 EASCALRLQSKSGLTRLFDFAFKHAMQTGMPRVTLADKPNVLRESGEFTRKIFESTAQRY 228 Query: 217 PDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQG 276 P ++ + +D + LIK P +F V++ N+FGDILSD A + G +G+ PSA++ ++G Sbjct: 229 PKIQADILNVDAVALWLIKSPEKFGVIVAENMFGDILSDVGAGVMGGLGLAPSANIGDKG 288 Query: 277 FGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEG-IR 335 +EP GS P I KN ANP A L++++LL + D A I A+ + ++E Sbjct: 289 -SYFEPVHGSGPRIR-KNCANPSAMFLTISMLLNH-FGYPDRAKKIVNAVMQVIKEKRFI 345 Query: 336 TGDLARGAAAVSTDEMGDIIARYVA 360 T DL +T +M + + + A Sbjct: 346 TYDL---GGHATTTDMANAVIEHCA 367 >UniRef50_C5EHC0 3-isopropylmalate dehydrogenase n=1 Tax=Clostridiales bacterium 1_7_47FAA RepID=C5EHC0_9FIRM Length = 369 Score = 311 bits (798), Expect = 2e-83, Method: Composition-based stats. Identities = 126/361 (34%), Positives = 201/361 (55%), Gaps = 5/361 (1%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPAT 61 S+ Y IA++PGDG+GPE+ +A+ L + + G AA+D PLP + Sbjct: 11 SRIYTIALIPGDGVGPEITREAVLTLKRAGEVYGRSFQFTEAIAGTAALDRGQCPLPRES 70 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 ++ C +AD++L G + + L +++PE L LR L S++RP + L C Sbjct: 71 LKTCLEADSILMGKLAVGRHPGLKFEERPE-SILGLLRTGLCLRSDIRPCFFAEALRELC 129 Query: 122 PLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFE 181 PL+ +I G DIL +R++ GG++ + K A+DTE Y I AR+AF+ Sbjct: 130 PLKEEIRKKGMDILIIRDIAGGMFTTEGK-SSNLCNVRAAWDTESYDETLIRDSARLAFQ 188 Query: 182 SARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFD 241 A R+ KVTS+DKA +L SS+LWR+I+ E +YP++EL HM +D+ +L+ P FD Sbjct: 189 LAASRKRKVTSLDKAILLSSSVLWRQILEETHRDYPEIELEHMLVDHGAFKLVSSPDAFD 248 Query: 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEP--AGGSAPDIAGKNIANPI 299 V++ SN+FGDI++DE A +TG+ LP+ SLN + G+Y P ++AG ANP+ Sbjct: 249 VIVASNVFGDIIADEAAGLTGAGEFLPAGSLNAERKGIYCPNQLHQVHEELAGTGRANPV 308 Query: 300 AQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVS-TDEMGDIIARY 358 IL+ A++L YS A ++RA++ +E+GI G + T +G+ + Sbjct: 309 GMILAAAMMLEYSFGLVREAEGMKRAVSIVMEQGIHGRPCWSGGEQTADTAAIGEAVREC 368 Query: 359 V 359 + Sbjct: 369 L 369 >UniRef50_Q9U6V3 Isocitrate dehydrogenase gamma subunit n=4 Tax=Bilateria RepID=Q9U6V3_9BILA Length = 388 Score = 311 bits (796), Expect = 3e-83, Method: Composition-based stats. Identities = 86/362 (23%), Positives = 159/362 (43%), Gaps = 32/362 (8%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 + + +LPGDGIGPE++ K+ + + + + Sbjct: 44 RHTVTLLPGDGIGPEMLDIVQKIFTFAN----VPVDFEECQLDSKPTSPESDL--DNAIM 97 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 ++ + G++ D + + LR+ LF+N+ + Sbjct: 98 SIQRNGVAIKGNIET------KYDDPIFKSRNVELRRRLDLFANVLHCVSIPTIPT---- 147 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 G +I+ +RE T G Y G E ++ R ++ERI+R AF+ A Sbjct: 148 ----RHKGINIVMIRENTEGEYSGH----EHETVNGVVESLKICTREKLERISRFAFDYA 199 Query: 184 RK-RRHKVTSIDKANVLQ-SSILWREIVNEIA-TEYPDVELAHMYIDNATMQLIKDPSQF 240 R K+T++ KAN+ + + L+ ++V EIA EYP + M +DNA+MQL+ P QF Sbjct: 200 IAHNRKKITAVHKANIQKLADGLFLKVVGEIAEKEYPSITFDSMIVDNASMQLVSRPQQF 259 Query: 241 DVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIA 300 D++L NL+G+I+S+ + G G++ ++ ++ + IAG++IANP A Sbjct: 260 DIMLMPNLYGNIISNIACGLVGGPGLVSGMNIGDKYAVFETGTRNTGSGIAGQDIANPTA 319 Query: 301 QILSLALLLRYSLDADDAACAIERAINRALE-EGIRTGDLARGAAAVSTDEMGDIIARYV 359 I + +L + L + A I A+ A+ + + T D+ T ++ + + R + Sbjct: 320 FIRAGVDML-HYLGLTEYANLISDALFDAIVIKRLHTKDI---GGTAKTSDVVNAVMRNI 375 Query: 360 AE 361 Sbjct: 376 ES 377 >UniRef50_B1L5I7 Isocitrate dehydrogenase (NAD(+)) n=1 Tax=Candidatus Korarchaeum cryptofilum OPF8 RepID=B1L5I7_KORCO Length = 331 Score = 311 bits (796), Expect = 3e-83, Method: Composition-based stats. Identities = 103/360 (28%), Positives = 172/360 (47%), Gaps = 36/360 (10%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 IAV+ GDG+GPE+M L +L+ + G + G+P+ +E Sbjct: 2 RIAVIKGDGVGPEIMGATLSLLE-----RYIGADFIEIKAGKSYFIEEGKPIEDNAIEKI 56 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 + D++L G V P P LR+ FKL++N+RP + Y+G+ Sbjct: 57 RECDSLLKGPVATPTKGPSYP------SVNTLLRREFKLYANVRPFRSYEGIS------- 103 Query: 126 DIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA-R 184 D + VRE +Y+G ++A V + ERI+ AF A R Sbjct: 104 ---IRRIDTILVRENLECLYYGWE-----VEDEDRAIAMRVITKRGAERISEFAFNLAKR 155 Query: 185 KRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVL 243 + R +VT+I K N+L+ + L+ + +A+++ D+ +D A +L+K + FDV+ Sbjct: 156 EGRGRVTAIHKRNILKRTDGLFLDAFYRVASKF-DLRADDEIVDAAGYKLVKLDNAFDVM 214 Query: 244 LCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQIL 303 L NL+GDILSD A + GS+G+ SA + E F +EP G+ DIAGK +ANPI I+ Sbjct: 215 LTPNLYGDILSDVAAGVVGSIGLCGSAQIGED-FAAFEPIHGTGEDIAGKGVANPIGMII 273 Query: 304 SLALLLRYSLDA---DDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYVA 360 + +++L + + I A++ + + I T DL T+++ + I + Sbjct: 274 AASMMLDWLWERGRSPKRGEKIREAVDSVIRDRILTPDL---GGDFRTEQVVEKIVDRLR 330 >UniRef50_Q0X0C1 Putative dehydrogenase n=2 Tax=Streptomyces RepID=Q0X0C1_9ACTO Length = 362 Score = 310 bits (794), Expect = 5e-83, Method: Composition-based stats. Identities = 126/357 (35%), Positives = 180/357 (50%), Gaps = 19/357 (5%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 IAV+PGDGIGPEV+ AL VLDA+ I V G+ L + ++ Sbjct: 21 TIAVIPGDGIGPEVIEPALDVLDALGLGTRTDI---LDHVNADTYLRTGEALTGSDLDRI 77 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 ++A L G+VG P+ RG L LR L+ N RPA+L+ Sbjct: 78 RSSEAALLGAVGDPRLGDTSY----VRGVLTTLRLELDLYVNYRPARLWH---DRLSPLR 130 Query: 126 DIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARK 185 D A D + VRE T G+Y G G E A D ++ R + R+ AF +A Sbjct: 131 DPARRAIDCVIVRENTEGLYSGIGGGARTGTPEEIAVDVDLSTRHGVSRVLEFAFSAA-- 188 Query: 186 RRHKVTSIDKANVLQSSI-LWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLL 244 R V +DKAN +++ LW+ E +P + +H+Y+D A ++L DP+ FDV++ Sbjct: 189 -RRSVCLVDKANAVRNGGQLWQRCWGEAVARHPHIATSHLYVDTAALRLATDPTGFDVIV 247 Query: 245 CSNLFGDILSDECAMITGSMGMLPSASLNE-QGFGLYEPAGGSAPDIAGKNIANPIAQIL 303 +N +GDILSD A + G +G+ SA+LN G L+EP GSAPDIAG ANP IL Sbjct: 248 TNNSYGDILSDLTAALAGGLGVAASANLNPVTGRALFEPVHGSAPDIAGSGTANPFGAIL 307 Query: 304 SLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYVA 360 S+ALL + L ++ A A+ RA+ A+ G T DL + T E+G + + Sbjct: 308 SVALLAEH-LGRNEEADAVRRAVAAAVAAGRVTPDL---GGPLGTKEVGAAVLAELR 360 >UniRef50_O67480 Isocitrate dehydrogenase [NADP] n=5 Tax=Aquificales RepID=IDH_AQUAE Length = 426 Score = 309 bits (791), Expect = 1e-82, Method: Composition-based stats. Identities = 105/406 (25%), Positives = 170/406 (41%), Gaps = 62/406 (15%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRF---AMRITTSHYDVGGAAIDNHGQPLP 58 N I + GDGIGPE+ L +++ + + +I G A + G+ LP Sbjct: 36 PDNPIIPFIEGDGIGPEITQAMLLIINTAVEKTYNGSKKIYWVELLAGDKAEEKTGERLP 95 Query: 59 PATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLE 118 T++ +++ + G +G P + + R LR+ F +S +RP G Sbjct: 96 QETLDVLKESIVGIKGPLGTPVGKGV-------RSINSALRRAFDYYSAVRPVYWM-GQA 147 Query: 119 AFCPLRADIAANGFDILCVRELTGGIYFGQP-------------------KGREGSGQYE 159 P D++ RE T +Y G +E + Sbjct: 148 TPIPN-----PERVDLVVFRENTDDVYAGVEFFAGTPEAKKVREFLIKEMGAKEEGFPED 202 Query: 160 KAFDTEVYHRFEIERIARIAFESARKRRHK-VTSIDKANVLQ-SSILWREIVNEIATEYP 217 + F+ +R R A A + K V I K N+++ + + E+A E Sbjct: 203 VGITVKPMSEFKTKRHVRKALRYALENNKKNVAVIGKGNIMKATEGAFINWAFEVAEEPE 262 Query: 218 ----------------DVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMIT 261 V+L + D MQL+ P +DV++ NL GD +SD A + Sbjct: 263 FKGKVVTDPEAEPGEGQVKLTKVITDQMLMQLVLKPEAWDVIIAQNLNGDYVSDLAASLI 322 Query: 262 GSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACA 321 G G +PS ++ + G+ L+E G+A DIAGK IANP++ LS A++L Y + +AA Sbjct: 323 GGPGFVPSGNIGD-GYALFESTHGTAWDIAGKGIANPLSLTLSGAMMLEY-IGWKEAAQK 380 Query: 322 IERAINRALEEGIRTGDLARG-------AAAVSTDEMGDIIARYVA 360 + A+ R L E I T D+A G A AV T E + I++ + Sbjct: 381 VYDAVRRTLAEHIGTPDIASGFQKQGIEAKAVGTMEFAEEISKRIE 426 >UniRef50_B7UV18 Isocitrate dehydrogenase [NADP] n=9 Tax=Gammaproteobacteria RepID=B7UV18_PSEA8 Length = 418 Score = 308 bits (789), Expect = 2e-82, Method: Composition-based stats. Identities = 90/407 (22%), Positives = 160/407 (39%), Gaps = 63/407 (15%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRF---AMRITTSHYDVGGAAID--NHGQP 56 KN I + GDGIG ++ +KV+DA + +I G A + Sbjct: 26 PKNPIIPFIEGDGIGVDISPVMIKVVDAAVEKAYKGERKIAWMEVYAGEKATQVYDQDTW 85 Query: 57 LPPATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQG 116 LP T++ + G + P + R + LR+ L+ RP + ++G Sbjct: 86 LPQETLDAVRDYVVSIKGPLTTPVGGGI-------RSLNVALRQQLDLYVCQRPVRWFEG 138 Query: 117 LEAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEK---------------- 160 + + D++ RE + IY G + Sbjct: 139 VPSPVK-----KPGDVDMVIFRENSEDIYAGVEWKAGSPEAEKVIKFLTEEMGVKKIRFT 193 Query: 161 ---AFDTEVYHRFEIERIARIAFESARKR-RHKVTSIDKANVLQ-SSILWREIVNEIATE 215 + + +R+ R A + A R VT + K N+++ + +++ E+A + Sbjct: 194 ENCGIGIKPVSQEGTKRLVRKALQYAVDNDRSSVTLVHKGNIMKFTEGAFKDWGYEVARD 253 Query: 216 Y--------------------PDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSD 255 +V + + D Q++ P+++DV+ NL GD LSD Sbjct: 254 EFGAELLDGGPWMQFKNPKTGKNVVVKDVIADAMLQQILLRPAEYDVIATLNLNGDYLSD 313 Query: 256 ECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDA 315 A G +G+ P A+L++ ++E G+AP AG++ NP + ILS ++LR+ + Sbjct: 314 ALAAEVGGIGIAPGANLSDS-VAMFEATHGTAPKYAGQDKVNPGSLILSAEMMLRH-MGW 371 Query: 316 DDAACAIERAINRALEEGIRTGD---LARGAAAVSTDEMGDIIARYV 359 +AA I + N A+ T D L GA +S E GD + + Sbjct: 372 TEAADLIIKGTNGAIAAKTVTYDFERLMDGATLLSCSEFGDAMIAKM 418 >UniRef50_B2J8P1 3-isopropylmalate dehydrogenase n=3 Tax=Cyanobacteria RepID=B2J8P1_NOSP7 Length = 363 Score = 308 bits (789), Expect = 2e-82, Method: Composition-based stats. Identities = 145/358 (40%), Positives = 194/358 (54%), Gaps = 20/358 (5%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 +Y I +PG+GIGPEV+ +LK+L V + + +G A + G P AT E Sbjct: 8 SYRIVAIPGEGIGPEVVEASLKILQHVAKIQGFTLQVDYGWLGATAFEQLGSYFPQATTE 67 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 C+ AD ++FG+V +G LL LRKHF F NLRP + L L Sbjct: 68 LCDGADGIVFGAVS--------------QGGLLELRKHFDFFCNLRPIRSVNSLLHKSSL 113 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 R + G DIL VREL GIYFG P GR + + T Y+ EI RIAR A E A Sbjct: 114 RPE-KIQGLDILIVRELVSGIYFG-PSGRSSDERGNYGYHTMRYYDEEIRRIARKALEQA 171 Query: 184 RKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVL 243 + RR +T K N L W +V E AT++P+V + M +DN MQ++ +P +FDV+ Sbjct: 172 QYRRGLLTVAHKENALPHLH-WTRLVQEEATKFPNVIVEPMLVDNLAMQMVLNPQRFDVI 230 Query: 244 LCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQIL 303 L SNLFGDILSD + GS+G+L SASLN GFGLYE G+APDIAG IANP+ + Sbjct: 231 LASNLFGDILSDIGGALVGSIGLLGSASLNANGFGLYEAIHGTAPDIAGLGIANPLGTLG 290 Query: 304 SLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAA--VSTDEMGDIIARYV 359 + L+L+ AA I A +R L +G RT DL V+T + D++ + Sbjct: 291 ACVLMLQ-QWGEVQAAQQIIAAQDRILAKGYRTADLFTQGEEILVNTATLVDLLLEEL 347 >UniRef50_UPI00019260EC PREDICTED: similar to predicted protein isoform 1 n=4 Tax=Hydra magnipapillata RepID=UPI00019260EC Length = 389 Score = 308 bits (788), Expect = 3e-82, Method: Composition-based stats. Identities = 89/360 (24%), Positives = 157/360 (43%), Gaps = 31/360 (8%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 + ++++P DGIG ++ ++V + + + G + + Sbjct: 45 RHTVSLIPADGIGQSLIMGIVEVFQ----NSGVPVDFEECYITGDTNEEKMKSF-NDIKT 99 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 + L G+ + + LR L++N+ K Y + Sbjct: 100 SVLRNGTALKGNWAT-------SMGIDSKSYNVLLRHDLDLYANVVKFKSYPTVIT---- 148 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 N D++ +RE T G Y + G E ++ + + ERIA+ AF+ A Sbjct: 149 ----RHNNVDLIVIRENTEGEYTNL-EHENIPGVIEM---IKIITKKKSERIAKYAFDYA 200 Query: 184 RKR-RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFD 241 + R KVT++ KAN+++ S L+ ++ E+A YP+++ M IDN MQ++ P QFD Sbjct: 201 MENNRKKVTAVHKANIMKLSDGLFLKVCKEVAEGYPEIDFNDMIIDNCAMQMVSKPEQFD 260 Query: 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQ 301 V++ NL+G++LS+ A + G G+ + S DIA KNIANP++ Sbjct: 261 VIVTPNLYGNVLSNIAAALVGGPGLPHGENHGNGIHVFESGTRNSGMDIATKNIANPMSM 320 Query: 302 ILSLALLLRYSLDADDAACAIERAINRALEEGI-RTGDLARGAAAVSTDEMGDIIARYVA 360 + + LLR+ L A IE I++ + RT D+ ST E +I+ + V Sbjct: 321 LFAATALLRH-LQLSKHAQLIESCIHKIVTTNQARTVDI---GGNTSTSEFFEILVKEVE 376 >UniRef50_O43837 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial n=80 Tax=Eumetazoa RepID=IDH3B_HUMAN Length = 385 Score = 307 bits (787), Expect = 4e-82, Method: Composition-based stats. Identities = 88/361 (24%), Positives = 159/361 (44%), Gaps = 27/361 (7%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 ++ + +LPGDG+GPE+M +V A + + + + + L + Sbjct: 48 SFPVTMLPGDGVGPELMHAVKEVFKAAA----VPVEFQEHHLSEVQNMASEEKL-EQVLS 102 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 ++ + G + P + + LR+ LF+N+ K G Sbjct: 103 SMKENKVAIIGKIHTP-----MEYKGELASYDMRLRRKLDLFANVVHVKSLPGYMT---- 153 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 N D++ +RE T G Y + G E ++ R + +RIA+ AF+ A Sbjct: 154 ----RHNNLDLVIIREQTEGEYSSL-EHESARGVIE---CLKIVTRAKSQRIAKFAFDYA 205 Query: 184 -RKRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFD 241 +K R KVT++ KAN+++ L+ + E+A YP ++ M IDN MQL+++P QFD Sbjct: 206 TKKGRGKVTAVHKANIMKLGDGLFLQCCEEVAELYPKIKFETMIIDNCCMQLVQNPYQFD 265 Query: 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQ 301 VL+ NL+G+I+ + A + G G++P S + + A G+NIANP A Sbjct: 266 VLVMPNLYGNIIDNLAAGLVGGAGVVPGESYSAEYAVFETGARHPFAQAVGRNIANPTAM 325 Query: 302 ILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYVAE 361 +LS + +LR+ ++ + +RT D+ +T + + ++ Sbjct: 326 LLSASNMLRHLNLEYHSSMIADAVKKVIKVGKVRTRDM---GGYSTTTDFIKSVIGHLQT 382 Query: 362 G 362 Sbjct: 383 K 383 >UniRef50_A4WLX6 Isocitrate dehydrogenase (NADP) n=22 Tax=Archaea RepID=A4WLX6_PYRAR Length = 439 Score = 307 bits (787), Expect = 4e-82, Method: Composition-based stats. Identities = 106/410 (25%), Positives = 165/410 (40%), Gaps = 65/410 (15%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRF---AMRITTSHYDVGGAAIDNHGQPLP 58 I + GDGIGPEV A+KV + + + +IT VG A G LP Sbjct: 42 PDKVVIGYIEGDGIGPEVAYAAIKVANEAVEKAYGKSRQITWYEIVVGEKAEKLFGNRLP 101 Query: 59 PATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLE 118 ++E + L + P R + LR+ F L++N+RP K + GL Sbjct: 102 DQSIEVLRKIRVFLKAPLETPVGGGF-------RSINVTLRQLFDLYANIRPVKYFPGLP 154 Query: 119 AFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQ----------------YEKAF 162 + D++ RE T +Y G + Sbjct: 155 SPL-----RRPELVDLVIFRENTEDVYAGIEWPYNSPEAAKIREFLRREFGVNIRDDAGI 209 Query: 163 DTEVYHRFEIERIARIAFESARKRRHKV-TSIDKANVLQ-SSILWREIVNEIA------- 213 + +F +RIAR+A + A + + +V T + K N+ + + ++E E+A Sbjct: 210 GIKPISKFGTQRIARLALKFAIENKRRVVTVMHKGNIQKYTEGAFKEWAFEVARNEFREH 269 Query: 214 -------TEYPD------VELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMI 260 +Y V + DN QL+ ++DV+L NL GD +SDE A + Sbjct: 270 VVFEDELAQYGGSVPPGKVLVNDRIADNMLQQLLTRTGEYDVILAPNLNGDYVSDEAAGL 329 Query: 261 TGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAAC 320 G +G+ P + + G + EP G+AP GKN NP A IL+L L+ R+ L + A Sbjct: 330 VGGLGVAPGLDVGDWG-MMAEPVHGTAPKYRGKNYVNPTATILALELMFRF-LGWREVAE 387 Query: 321 AIERAINRALEEGIRTGDLARG----------AAAVSTDEMGDIIARYVA 360 I + + A EG TGDLAR + T E D + + Sbjct: 388 YIMKGVETAYREGYFTGDLARQMTDEERKMRVKEVLGTQEFADKVVEIIK 437 >UniRef50_A0D2B8 Chromosome undetermined scaffold_35, whole genome shotgun sequence n=4 Tax=Oligohymenophorea RepID=A0D2B8_PARTE Length = 355 Score = 306 bits (785), Expect = 6e-82, Method: Composition-based stats. Identities = 96/361 (26%), Positives = 159/361 (44%), Gaps = 48/361 (13%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMR----ITTSHYDVGGAAIDNHGQPLPPAT 61 ++ ++PG GIGPE+ V +A+ + + Sbjct: 34 NVTLIPGVGIGPEITNSVKTVFEALHVPIKFDVLDNFNFEN----------------DDS 77 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 + + +L G + ++ + K+ L+SN+ A +G+ Sbjct: 78 KSQLRKNECILLG---------VMTEKNQKYTDNYKFYKYLDLYSNITFAFSVEGITQ-- 126 Query: 122 PLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFE 181 N DI+ +RE T G Y G E +V + RIA AFE Sbjct: 127 ------RHNNTDIVVIRENTEGEYSG----VEHEVYPGVVESIKVTTKQASLRIAEYAFE 176 Query: 182 SA-RKRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQ 239 A R KVT++ KAN+++ L+ + E+A Y ++ M IDN MQL+K+P+Q Sbjct: 177 FAHLSGRRKVTAVHKANIMKLVDGLFLQACREVAQRYSFIKYEEMIIDNCCMQLVKNPTQ 236 Query: 240 FDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPI 299 FDV++ NL+G I+ + A ITG +GM AS+ + + + DIAGKN+ NP Sbjct: 237 FDVMVMPNLYGSIVQNVVAGITGGVGMAAGASIGKDHALFSQGCRHTGRDIAGKNVVNPS 296 Query: 300 AQILSLALLLRYSLDADDAACAIERAINRALEE-GIRTGDLARGAAAVSTDEMGDIIARY 358 A ++S LLLR+ L + A I RA+ +++ I+T D+ +TD+ + R Sbjct: 297 AMLVSSTLLLRH-LGLPNFADQICRAVQHTIQDKKIKTKDI---GGNATTDQFTSEVIRS 352 Query: 359 V 359 + Sbjct: 353 L 353 >UniRef50_D1B6F8 3-isopropylmalate dehydrogenase n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B6F8_THEAS Length = 420 Score = 302 bits (774), Expect = 1e-80, Method: Composition-based stats. Identities = 117/396 (29%), Positives = 173/396 (43%), Gaps = 55/396 (13%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDN------HGQ 55 Y + +PGD G ++M AL VL + I D+G + G Sbjct: 12 KDRYKVCYMPGDDSGFDMMEGALVVL----LSMDLPIDWVRADLGWCMWEKSVNKFGQGD 67 Query: 56 P----LPPATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPA 111 P +PP T++ +DA L ++ + + A+L +R+ F L+ NLRPA Sbjct: 68 PRCNTVPPETIDKIRSSDATLMAAITSKSG------VKGFKSAILQMRQLFDLYINLRPA 121 Query: 112 KLYQGLEAFCPLRADIAANGFDILCVRELTGGIYFGQPKG-------------REGSGQY 158 K L PL+ D D++ RE T +Y Sbjct: 122 KTLPDL--GSPLKGDPK---IDLVLFRENTEDLYSAVEFHPLPEEMFNLHKGMERFRKMG 176 Query: 159 EKAFDTEVYHRFEIERIARIAFESARK-RRHKVTSIDKANVLQ-SSILWREIVNEIATEY 216 + A V+ ERI R AFE A+ R KV +KANV++ + + + I E+A EY Sbjct: 177 DVAVSWRVFSSVGCERIIRAAFEYAKSTGRTKVHCCNKANVIRETDGMMKRIFLEVAKEY 236 Query: 217 PDVELA--HMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNE 274 + D M LIK+P + V++ SN+FGDILSDE + +TG +G PS ++ Sbjct: 237 EQYGITGIEENADATAMWLIKNPQDYQVIVTSNVFGDILSDEASQLTGGLGFAPSGNIG- 295 Query: 275 QGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEE-- 332 + ++EP GS P A + NP A +L+ ++L Y L D A IE AIN L+E Sbjct: 296 ENTAIFEPCSGSVPKYAHQYRVNPSAMLLTSKMMLEY-LGLDQAGQKIEWAINEVLKENR 354 Query: 333 -GIRTGDLARG--------AAAVSTDEMGDIIARYV 359 T D+ R A ST EM IA+ + Sbjct: 355 PKTLTYDILRDFRNDPDWERNAASTIEMATAIAQKI 390 >UniRef50_A6G3V7 Probable 3-isopropylmalate dehydrogenase n=2 Tax=root RepID=A6G3V7_9DELT Length = 368 Score = 302 bits (774), Expect = 1e-80, Method: Composition-based stats. Identities = 110/368 (29%), Positives = 166/368 (45%), Gaps = 25/368 (6%) Query: 20 MTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQ-PLPPATVEGCEQADAVLFGSVGG 78 M + LKVL AV + GG G P + C+ AD +L G+VG Sbjct: 1 MREGLKVLHAVSEPLGIEWAIEDVPCGGQYYLEQGDLDWPSDAPQKCDAADLILLGAVGW 60 Query: 79 PKWEH------LPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC--PLRADIAAN 130 P + ++ ++ R L++N+RP KLY G++ + A Sbjct: 61 PDPAGTGGPVLMKDNKMAGFSPVIGNRMRLNLYANVRPIKLYPGVQHRIHGGHKQIWEAG 120 Query: 131 GFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARKRRH-- 188 D++ +RE T G+Y G+ + A DT V R E++ R AFE ++R Sbjct: 121 KVDMVIIRENTEGLYAPTGGKLAPGGKADVAIDTRVITRRACEQVIRHAFELCKRRNKGA 180 Query: 189 ------KVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDV 242 +VT+I K NVL L+R++ EI EYP++E +D T L+ P +DV Sbjct: 181 PKDGKLRVTAIIKDNVLHGCQLFRDVFFEIGAEYPEIEKDTAIVDAFTQWLVGQPEYYDV 240 Query: 243 LLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQI 302 + SN+FGDI++D + + G MGM ++ + ++EP GSAP AGK+ NPIA I Sbjct: 241 CVTSNMFGDIVTDLASTLQGGMGMAVGGNIG-KHNAMFEPIHGSAPKHAGKDKVNPIAMI 299 Query: 303 LSLALLLRYSLDADDAACAIE------RAINRALEEG-IRTGDLARGAAAVSTDEMGDII 355 LS+ L + D A + A+ LE+G T DL A E+G I Sbjct: 300 LSVKEGLEWLAARKDDATLTKAAEAIEAAVVEVLEKGETLTYDLVGNDRASKCSEVGSAI 359 Query: 356 ARYVAEGV 363 A + Sbjct: 360 AEAAVRKL 367 >UniRef50_D2SEJ6 3-isopropylmalate dehydrogenase n=3 Tax=Actinomycetales RepID=D2SEJ6_9ACTO Length = 340 Score = 301 bits (772), Expect = 2e-80, Method: Composition-based stats. Identities = 135/356 (37%), Positives = 197/356 (55%), Gaps = 25/356 (7%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 +AV+PGDGIGPEV+ + LKVL AV + ++ YD+G + G+ LP ++ Sbjct: 2 RLAVIPGDGIGPEVVAEGLKVLRAVAP----DVESTPYDLGASRWQRTGELLPDTVLDEL 57 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 + DA+L G++G P P ERG LL LR NLRPA+L+ G+ + Sbjct: 58 RRHDAILLGAIGDPS----VPPGILERGLLLRLRFELDHHVNLRPARLFDGVRSPL---- 109 Query: 126 DIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARK 185 A D+LCVRE T G Y G +E A + + F +ER+ R AFE A Sbjct: 110 -AAPGAIDMLCVREGTEGPYVGNGGVLRRDTPHEVATEVSLNTAFGVERVVRYAFERALA 168 Query: 186 R-RHKVTSIDKANVLQSSI-LWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVL 243 R R +T I K NVL + LW V E++ E+P+V +A+ ++D A+M + DP +FDV+ Sbjct: 169 RPRRHLTLIHKTNVLTHAGSLWSRTVEEVSAEFPEVTVAYQHVDAASMFFVTDPGRFDVI 228 Query: 244 LCSNLFGDILSDECAMITGSMGMLPSASLNEQG--FGLYEPAGGSAPDIAGKNIANPIAQ 301 + NLFGDI++D A +TG +G+ S +L+ G ++EP GSAPDIAGK +A+P A Sbjct: 229 VTDNLFGDIVTDLAAAVTGGIGLAASGNLDASGTNPSMFEPVHGSAPDIAGKGVADPTAT 288 Query: 302 ILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIAR 357 +LS+ LLL + AD A +N A+ + T D A V T+++GD +A Sbjct: 289 VLSVGLLLDHLGRADQARK-----VNAAVAFDLSTRD---PEAQVRTEDVGDRLAA 336 >UniRef50_Q4P2R4 3-isopropylmalate dehydrogenase n=1 Tax=Ustilago maydis RepID=Q4P2R4_USTMA Length = 363 Score = 301 bits (771), Expect = 3e-80, Method: Composition-based stats. Identities = 135/374 (36%), Positives = 203/374 (54%), Gaps = 37/374 (9%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPAT 61 K + + VL GD IGPEVM + L + D +++ F +++ T +GG+ +D H P+ +T Sbjct: 10 PKAFKVMVLQGDHIGPEVMAEVLPLFDVIQSHFGIKVETFERLIGGSCLDQHDCPIQEST 69 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 ++ + AVL GSVGGPKW+ ++PE G +L +RKH L++N+RPAK+ + Sbjct: 70 LQEASECHAVLLGSVGGPKWDVGDSSRRPETG-ILRMRKHLNLYANVRPAKIISERQLEL 128 Query: 122 PLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFE 181 + G +I+ +RE GGIYFG+ + + + A Sbjct: 129 SSLKEHVVRGVNIITLRENAGGIYFGRKQEPDPLAH-------------------KAALS 169 Query: 182 SARKRRH-KVTSIDKANVLQSSILWREIVNE-IATEYPDV--ELAHMYIDNATMQLIKDP 237 A + S+DKANV+ +S LWR++V E I E+P + +L+H +D+A M L KDP Sbjct: 170 LASSHGPLPIISVDKANVMATSRLWRQVVTETIRDEFPQLMDKLSHQLVDSAAMLLAKDP 229 Query: 238 SQFD-VLLCSNLFGDILSDECAMITGSMGMLPSASL-NEQGFG--------LYEPAGGSA 287 + + V+L NLFGDILSD ++I GS+G+L SA + +Y+P GSA Sbjct: 230 RKLNGVVLTENLFGDILSDLTSVIPGSLGVLGSAEIDGPPIPSQDFRMPMGVYQPVSGSA 289 Query: 288 PDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVS 347 PDIAGK IANPI +S L+ R+SL AA AI+ AI LE G T D+ +S Sbjct: 290 PDIAGKGIANPIGMFMSFGLMCRWSLGLPKAADAIDSAIKDCLESGQCTRDV---GGTLS 346 Query: 348 TDEMGDIIARYVAE 361 T + G + + + E Sbjct: 347 TQQAGSALRQSIQE 360 >UniRef50_A0P1S6 3-isopropylmalate dehydrogenase n=3 Tax=Rhodobacterales RepID=A0P1S6_9RHOB Length = 369 Score = 299 bits (767), Expect = 7e-80, Method: Composition-based stats. Identities = 117/367 (31%), Positives = 171/367 (46%), Gaps = 18/367 (4%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMR-ITTSHYDVGGAAIDNHGQPLPPATVEG 64 IA++ GDGIG +V A+ VL+ G G + E Sbjct: 2 KIALIKGDGIGVDVAEAAIAVLETALKHTGEPAPRYDEIQAGAGYFKETGLDIEDGGEER 61 Query: 65 CEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 ADA+ G++G P H E L LR F L++ +RP K Y Sbjct: 62 AGLADAIFLGAIGLPSIRHA---NGTEISPHLRLRDRFGLYAGVRPVKAYPNAPQ---RL 115 Query: 125 ADIAANGFDILCVRELTGG-IYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 AD A G D++ +RE T G Y R ++ D R ++ R AF A Sbjct: 116 ADPRAAGIDLVILRESTEGLFYSAAAHKRSLVVNDDEVQDVLRITRKTTTKLHRFAFNLA 175 Query: 184 RKRR-----HKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPS 238 RKRR ++T +DKANV S +R+I +E+ +E+ DV + + Y+D + L++ P Sbjct: 176 RKRRERGHPGRLTCVDKANVFTSLAFFRQIFDEVKSEFADVPVGYNYVDAQALDLVRKPW 235 Query: 239 QFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANP 298 +FDVL+ N+FGDILSD + G MGM + + GL++PA GSAPDI G++ ANP Sbjct: 236 EFDVLVMENMFGDILSDLAGGLVGGMGMAACGEIGDT-TGLFQPAHGSAPDIMGEDKANP 294 Query: 299 IAQILSLALLLRYSLDADDAACAIERA--INRALEEGIRTGDLA--RGAAAVSTDEMGDI 354 +A ILS AL+L Y + D + A I+ A+E G L + T + Sbjct: 295 LAAILSAALMLDYLAEKLDKPSLADAAELIDSAVETGFWHNALRPIEFGGDMGTRAVTKE 354 Query: 355 IARYVAE 361 + VA+ Sbjct: 355 LLGRVAQ 361 >UniRef50_P41560 Isocitrate dehydrogenase [NADP] 1 n=78 Tax=cellular organisms RepID=IDH1_COLMA Length = 415 Score = 298 bits (763), Expect = 2e-79, Method: Composition-based stats. Identities = 86/407 (21%), Positives = 154/407 (37%), Gaps = 64/407 (15%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRF---AMRITTSHYDVGGAAIDNHG--QP 56 N I + GDGIG +V LKV++A + +I G A + Sbjct: 24 PNNPIIPYIEGDGIGVDVTPPMLKVVNAAVAKAYGGDRKIEWLEVYAGEKATKMYDSETW 83 Query: 57 LPPATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQG 116 LP T+ ++ + G + P + + +R+ L+ RP + + G Sbjct: 84 LPEETLNILQEYKVSIKGPLTTPVGGGMS-------SLNVAIRQMLDLYVCQRPVQWFTG 136 Query: 117 LEAFCPLRADIAANGFDILCVRELTGGIYFGQP-------------------KGREGSGQ 157 + + + D++ RE T IY G Sbjct: 137 VPSPVK-----RPSEVDMVIFRENTEDIYAGIEYKAGSDKAKSVIKFLIEEMGASNIRFT 191 Query: 158 YEKAFDTEVYHRFEIERIARIAFESARKRRH-KVTSIDKANVLQ-SSILWREIVNEIATE 215 + + +R+ R A + A VT + K N+++ + +++ E+A E Sbjct: 192 ENCGIGIKPVSKEGSQRLVRQAIQYAIDNNKDSVTLVHKGNIMKFTEGAFKDWGYELAIE 251 Query: 216 Y--------------------PDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSD 255 ++ + + D Q++ P+++ V+ NL GD LSD Sbjct: 252 EFGASLLHGGPWCSLKNPNTGKEIIIKDVIADAMLQQVLLRPAEYSVIATLNLNGDYLSD 311 Query: 256 ECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDA 315 A G +G+ P A+L ++ ++E G+AP AGKN NP + ILS ++LR+ Sbjct: 312 ALAAQVGGIGIAPGANLGDE-VAVFEATHGTAPKYAGKNKVNPGSVILSAEMMLRHMGWL 370 Query: 316 DDAACAIERAINRALEEGIRTGD---LARGAAAVSTDEMGDIIARYV 359 A + + ++ A++ T D L A VS GD I ++ Sbjct: 371 --EADLLLKGMSGAIQAKTVTYDFERLMDDATLVSCSAFGDCIIDHM 415 >UniRef50_Q9ZN36 Isocitrate dehydrogenase [NADP] n=932 Tax=root RepID=IDH_HELPJ Length = 425 Score = 297 bits (760), Expect = 5e-79, Method: Composition-based stats. Identities = 92/414 (22%), Positives = 157/414 (37%), Gaps = 71/414 (17%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRF---AMRITTSHYDVGGAAIDNHGQ--- 55 I + GDGIG ++ +KV+D+ + +I VG Sbjct: 27 PNYPIIPFIEGDGIGSDITPAMIKVVDSAVQKAYKGEKKIAWYEVFVGEKCYQKFKDHKE 86 Query: 56 ------PLPPATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLR 109 L P T+E + G + P E R + LR+ L+ LR Sbjct: 87 LSPEEQWLLPDTIEAINHYKVSIKGPLTTPIGEGF-------RSLNVALRQKMDLYVCLR 139 Query: 110 PAKLYQGLEAFCPLRADIAANGFDILCVRELTGGIYFGQP-------------------K 150 P + Y + P++ D++ RE + IY G K Sbjct: 140 PVRWY---GSPSPVKE---PQKVDMVIFRENSEDIYAGIEWQEGSAEAKKLIHFLQNELK 193 Query: 151 GREGSGQYEKAFDTEVYHRFEIERIARIAFESARKRRHK-VTSIDKANVLQ-SSILWREI 208 + + + ER+ R A E A VT + K N+++ + + + Sbjct: 194 VEKIRFPESSGVGIKPISKEGTERLVRKAIEYAIDNDKPSVTFVHKGNIMKYTEGAFMKW 253 Query: 209 VNEIA-TEY-------------------PDVELAHMYIDNATMQLIKDPSQFDVLLCSNL 248 +A E+ ++ + M D Q++ PS++ V+ NL Sbjct: 254 GYALAQKEFNAQVIDKGPWCSLKNPKTGKEIIIKDMIADAFLQQILLRPSEYSVIATMNL 313 Query: 249 FGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALL 308 GD +SD A + G +G+ P A+LN+ G++E G+AP AG + NP + ILS ++ Sbjct: 314 NGDYISDALAAMVGGIGIAPGANLNDT-VGMFEATHGTAPKYAGLDKVNPGSIILSAEMM 372 Query: 309 LRYSLDADDAACAIERAINRALEEGIRTGD---LARGAAAVSTDEMGDIIARYV 359 LR+ + +AA I A+ +A++ T D L GA V E ++ + Sbjct: 373 LRH-MGWVEAADLIVSAMEKAIKSKKVTYDFARLMDGAKEVKCSEFASVMIENM 425 >UniRef50_A9A2N6 Isocitrate dehydrogenase (NAD(+)) n=11 Tax=Archaea RepID=A9A2N6_NITMS Length = 343 Score = 294 bits (752), Expect = 4e-78, Method: Composition-based stats. Identities = 112/372 (30%), Positives = 173/372 (46%), Gaps = 40/372 (10%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHG----QP 56 MSK AV+ GDGIGPEV+ L+VL + + + + G D +G Sbjct: 1 MSK--KAAVMKGDGIGPEVVDSMLRVLKECNFQSELIL----CEAGSEQWDKNGRKDASY 54 Query: 57 LPPATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQG 116 +P T++ E+ D G P R + LR+ F L++N+RP K Y Sbjct: 55 IPDVTMKILEETDCCFKGPTTTIPVPGAP------RSVAVTLRQKFDLYANIRPTKTYDR 108 Query: 117 LEAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIA 176 L D +C RE T G+Y G E + A R R+ Sbjct: 109 L---------TPDRKLDCVCFREATEGLYTG----VEAKITDDAAIAIRKITRQGSRRLI 155 Query: 177 RIAFESARK-RRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLI 234 A + A K K+ ++ K N+L+ + ++ + + A E D+EL+ +YIDN Q++ Sbjct: 156 DSAVDWANKFNMKKMVAVTKRNILKQTDGIFWDETQK-AVEGTDIELSEIYIDNMAQQMV 214 Query: 235 KDPSQFD--VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAG 292 QF+ VL+ +NLF DI+S+ + + GS+G++ SA++ + + ++E A GSAP AG Sbjct: 215 IATEQFNGAVLVSTNLFMDIISELASALVGSIGLIYSANIGDN-YAMFEAAHGSAPQFAG 273 Query: 293 KNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGI-RTGDLARGAAAVSTDEM 351 +N NP A +LS A + Y L D AI A + + EG T D+ ST +M Sbjct: 274 QNKVNPTATVLSGAWMADY-LGERDVRDAIFAATEQVINEGKAVTWDI---GGDASTTQM 329 Query: 352 GDIIARYVAEGV 363 D I Y E + Sbjct: 330 TDAIITYAKEKL 341 >UniRef50_Q3IKZ8 Isocitrate dehydrogenase, specific for NADP+ n=3 Tax=Alteromonadales RepID=Q3IKZ8_PSEHT Length = 419 Score = 291 bits (746), Expect = 2e-77, Method: Composition-based stats. Identities = 95/405 (23%), Positives = 158/405 (39%), Gaps = 61/405 (15%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNR---FAMRITTSHYDVGGAAIDNH-GQP 56 + IA + GDG+G +VM KV+D+ +I G A + G Sbjct: 28 IPLQPIIAYIDGDGVGQDVMPVMRKVVDSAIAHCYQAKRKIHWMQVYNGEQAAKLYDGDW 87 Query: 57 LPPATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQG 116 P T+ + + G + P R + LR+ LF N+R K + Sbjct: 88 FPQETINAVRECKIAIKGPLTTPLGGGF-------RSLNVALRQEMDLFVNMRTIKGFSA 140 Query: 117 LEAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEK---------------- 160 L PL+ +I +R+ + +Y G + Sbjct: 141 LP--SPLKNPYL---TNITVLRDSSEDVYSGIEWQAGSVESEKVLDFLCEEMGVTRLRFT 195 Query: 161 ---AFDTEVYHRFEIERIARIAFESARKRRHK-VTSIDKANVLQ-SSILWREIVNEIAT- 214 + + ER+ R A A K + +T + K NVL+ + ++ +A Sbjct: 196 QECGIGIKNISKEGSERLVRYAINYALKNNSESLTLVHKGNVLKFTDGAFKRWGFALAKR 255 Query: 215 EY------------------PDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDE 256 EY P + + + DN Q + P QFDV+ +N GD L+D Sbjct: 256 EYQAIDDENGRWLHIPRQGQPPLIIKEVIADNMLQQCLMHPEQFDVVATTNQNGDFLADM 315 Query: 257 CAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDAD 316 + G +G++P+A+LN + +EP G+ IAG+N ANP + ILS L+L++ + Sbjct: 316 LSAQVGGVGIMPAANLNNE-VAFFEPTHGTFARIAGQNKANPSSSILSAVLMLKF-MQWH 373 Query: 317 DAACAIERAINRALEEGIRTGDLAR---GAAAVSTDEMGDIIARY 358 +AA IE A+ R L G T DL + +S + + + Sbjct: 374 EAANLIENALERTLAAGEVTFDLLSEPHNSMPLSCTDFALRVIEH 418 >UniRef50_Q18GT1 3-isopropylmalate dehydrogenase n=8 Tax=Halobacteriaceae RepID=Q18GT1_HALWD Length = 334 Score = 286 bits (732), Expect = 8e-76, Method: Composition-based stats. Identities = 122/365 (33%), Positives = 181/365 (49%), Gaps = 36/365 (9%) Query: 1 MSK--NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLP 58 MS+ + I V+ GDGIG EV+ A+ VL AV + + + G D G LP Sbjct: 1 MSRGGEHEIVVIEGDGIGQEVIPAAVAVLQAVDE---VGFSFTEKQAGDDTRDQTGAALP 57 Query: 59 PATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLE 118 T E ADA LFG+ G + +LPLR+ F N+RPA+ Y G++ Sbjct: 58 ETTYEAAADADATLFGAAG-----------ETAADVILPLREAVGSFVNIRPARAYPGVD 106 Query: 119 AFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARI 178 A P D++ +RE T G+Y G + + T V E++A Sbjct: 107 ALQP--------ETDLVFLRENTEGVYSGHEDRLS----EDLSTLTRVITTSASEQLAEY 154 Query: 179 AFESARKRR-HKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKD 236 A +R ++ KANV+Q + +R+ V+ +A DV + +D ++ + Sbjct: 155 ACSYVTERSIDGFHTVHKANVMQETDGRFRDAVSRVAAS-NDVATNEVLMDAFATRVCLN 213 Query: 237 PSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIA 296 P+QFDV++C NL GD+LSD A + G +G+LPSA++ Q L+EP G+APDIAG IA Sbjct: 214 PTQFDVVVCPNLAGDVLSDLAAGLVGGLGLLPSANIG-QTNALFEPVHGTAPDIAGDGIA 272 Query: 297 NPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIA 356 NP A ILS +LL Y L DAA ++ A+ L G RT DL ST+ + + + Sbjct: 273 NPSASILSAGMLLEY-LGETDAATNVQMAVESVLNSGPRTPDL---GGNASTEAVVNAVI 328 Query: 357 RYVAE 361 ++ Sbjct: 329 EQLSS 333 >UniRef50_D2Y061 Isocitrate dehydrogenase n=1 Tax=Bombyx mori RepID=D2Y061_BOMMO Length = 388 Score = 285 bits (729), Expect = 2e-75, Method: Composition-based stats. Identities = 101/359 (28%), Positives = 156/359 (43%), Gaps = 32/359 (8%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 + + +LPG GIGPE M + + I D+ +DN + Sbjct: 56 RHAVTMLPGGGIGPECMGYVRDIFKYI----GAPIDFEVVDIDP-TMDNDDDV--QYAIT 108 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 ++ L G++ + LR +++ + K Y G+ Sbjct: 109 TIKRNGVGLKGNIETKSEAAYVT------SRNVALRNELDMYAYILNCKSYPGVAT---- 158 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA 183 D++ +R+ T G Y E +V ER+AR AFE A Sbjct: 159 ----RHKDIDVVIIRQNTEGEYA----MLEHESVNGVVESMKVVTADNSERVARFAFEFA 210 Query: 184 RKR-RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFD 241 +K R KVT++ KAN+++ S L+ E +A EYPD+E M IDN MQL+ P QFD Sbjct: 211 KKNGRKKVTTVHKANIMKLSDGLFLETSRRLAKEYPDIEHDDMIIDNCCMQLVAKPHQFD 270 Query: 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQ 301 V+L +NL+G I+S+ + G G+L + + + IAGKNIANPIA Sbjct: 271 VMLMTNLYGSIVSNVVCGLLGGAGLLSGRNYGDHYAVFEPGTRNTGTAIAGKNIANPIAM 330 Query: 302 ILSLALLLRYSLDADDAACAIERAINRALE-EGIRTGDLARGAAAVSTDEMGDIIARYV 359 I + +L + L A + RAIN+ + + + T DL + STD +G I + V Sbjct: 331 INASIDMLEH-LGHQFHASLLRRAINKTINVDRVLTPDLG--GSNTSTDVVG-AILQNV 385 >UniRef50_Q0A635 Isocitrate/isopropylmalate dehydrogenase n=1 Tax=Alkalilimnicola ehrlichii MLHE-1 RepID=Q0A635_ALHEH Length = 382 Score = 281 bits (718), Expect = 4e-74, Method: Composition-based stats. Identities = 128/362 (35%), Positives = 181/362 (50%), Gaps = 15/362 (4%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITT-SHYDVGGAAIDNHGQPLPPAT 61 + + + VLPG+G+GPEV+ AL +L + R + +G A G+ L P Sbjct: 26 EAFLVGVLPGEGVGPEVIDVALSLLRLLGEATGQRFEVRTGGPIGRQAERLTGRGLTPEV 85 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 + C Q A + GP D LR+HF L+ L P + + L Sbjct: 86 RDFCAQVFAQGGAVLCGPGGGRFVYD----------LRRHFDLYCKLIPLRHWPALADAG 135 Query: 122 PLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFE 181 LR + AA D+L VRE G+Y G+ G EG G A+ Y E+ERI R A Sbjct: 136 VLRPE-AARSADVLIVRENASGLYCGE-WGSEGEGAARSAYQVCRYRADEVERILRTALR 193 Query: 182 SARKRRHKVTSIDKAN-VLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQF 240 A +RR + + K V S LW + + +A E+ V + +DNA QLI DP QF Sbjct: 194 LAGQRRGDLVVVTKPGGVPAISALWHDALTAVAGEHGAVRCRTLEVDNAAYQLIADPRQF 253 Query: 241 DVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIA 300 DV++C N+FGDIL D +++ GS GM S + G +Y+ A G+A D+AG++ ANPI Sbjct: 254 DVIVCPNMFGDILGDCGSLLMGSRGMSWSGNYGAAGQAVYQTAHGAAWDLAGRDRANPIG 313 Query: 301 QILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGA-AAVSTDEMGDIIARYV 359 Q+ SLA++LR S A A+E AI R L G+RT D+ AV T MG + + Sbjct: 314 QVCSLAMMLRESFRLPALADALETAIARTLARGVRTADIQGAQPTAVGTRAMGQALCASL 373 Query: 360 AE 361 E Sbjct: 374 TE 375 >UniRef50_A1WV93 3-isopropylmalate dehydrogenase n=8 Tax=Gammaproteobacteria RepID=A1WV93_HALHL Length = 389 Score = 281 bits (718), Expect = 4e-74, Method: Composition-based stats. Identities = 125/387 (32%), Positives = 178/387 (45%), Gaps = 39/387 (10%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATV 62 +++ +AV+PGDGIGPEVM L+A+ + +T + D HG+ +P Sbjct: 6 ESWQVAVMPGDGIGPEVMAATRHALEALPGPA-LVLTELGWPAHAWHRD-HGEMMPADWR 63 Query: 63 EGCEQADAVLFGSVGGPKWEHLP-----PDQQPERGALLPLRKHFKLFSNLRPAKLYQGL 117 DA+L G++G P H PD LL LRK L++ RPA G Sbjct: 64 GQLAGYDALLLGALGDPGPSHDAQRYCLPDGVSLA-PLLQLRKGLDLWACERPAVPLAGA 122 Query: 118 EAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIAR 177 +D A D+L +RE + G Y Q E A EV+ R ERI R Sbjct: 123 PMPL---SDPRALHTDLLVIRENSEGEYVDQGGRLAAGTPRETATQLEVFTRAGTERIIR 179 Query: 178 IAFESA-----------RKRR---------HKVTSIDKANVLQSSI-LWREIVNEIATEY 216 AFE A R R V + K N +Q + LW E+ E+A EY Sbjct: 180 HAFERAARRAEERRQGLRAPRYAAADGAADAAVCVVTKRNAVQYAGELWSEVFAEVAAEY 239 Query: 217 PDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQG 276 P + H ID M+ + P QFDV++ SNL GDIL+D A++ G MG+ PSA+LN Sbjct: 240 PGIATHHELIDACCMKFVSQPWQFDVVVASNLHGDILTDLAAVLAGGMGVAPSANLNPAD 299 Query: 277 FGL---YEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEG 333 + +EP GSAPDIAG + A+P A +L+ A +L + + D A + RA+ E Sbjct: 300 RSVPPLFEPTHGSAPDIAGADRAHPAAMLLTAAAMLEWMGEVDPVAARSAVQLQRAVAED 359 Query: 334 IRTGDLARGAAAVSTDEMGDIIARYVA 360 I + E+G +A+ + Sbjct: 360 IAEHGMGGRG----CAEVGRAVAQRIR 382 >UniRef50_D2VM48 Isocitrate dehydrogenase n=1 Tax=Naegleria gruberi RepID=D2VM48_NAEGR Length = 432 Score = 277 bits (709), Expect = 4e-73, Method: Composition-based stats. Identities = 98/410 (23%), Positives = 166/410 (40%), Gaps = 79/410 (19%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAI--------------- 50 + +LPGDGIG E+ + ++ + I Y V G+ Sbjct: 39 KVTLLPGDGIGVEICSCVCELFHYAN----IPIQWDTYLVSGSFFGVGSDSSLNPTRNLI 94 Query: 51 ----DNHGQPLP-----------------------PATVEGCEQADAVLFGSVGGPKWEH 83 G+ P P + VL G Sbjct: 95 EEDPRRRGETNPSGGTAYSYLRKEKWSQIDPEVHYPDLHQSILNNKVVLKGPFITRDVS- 153 Query: 84 LPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRADIAANGFDILCVRELTGG 143 + L + L++++ P K Q L P D++ VRE T Sbjct: 154 --------KSIDRMLALKYGLYAHVVPVKAPQNL----PPSVFTPFRDVDMVVVRENTEA 201 Query: 144 IYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARK-RRHKVTSIDKANVLQ-S 201 Y G E Q ++ R RIA+ AFE A++ +R KV +I KAN+++ S Sbjct: 202 EYSG----LEHQVQPGVVESLKIITRDGSMRIAKWAFEYAKQSKRSKVIAIHKANIMKKS 257 Query: 202 SILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFD--VLLCSNLFGDILSDECAM 259 L+ E ++A EYPD++ + + +DNA MQL+K+P FD V++ NL+G I+S+ + Sbjct: 258 DGLFIECCKQVAKEYPDIQYSELIVDNAVMQLVKNPHSFDNSVVVTPNLYGSIVSNTASS 317 Query: 260 ITGSMGMLPSASLNE----QGFGLYEPA-GGSAPDIAGKNIANPIAQILSLALLLRYSLD 314 + G +G++ + + ++E A DI+G+ IANPI I S +L + + Sbjct: 318 LVGGVGVISGFNATDINKPDAVRVFEQGNRHVAMDISGRLIANPIGLISSSIQMLDH-MG 376 Query: 315 ADDAACAIERAINRAL---EEGIRTGDLARGAAAVSTDEMGDIIARYVAE 361 + A I+ A+ L I T D+ ++VS + + R++ + Sbjct: 377 MNTHANRIKFALKETLLNANPKILTPDIGGTGSSVS---FIEAMMRHIPK 423 >UniRef50_O15384 NAD (H)-specific isocitrate dehydrogenase gamma subunit (Fragment) n=42 Tax=Coelomata RepID=O15384_HUMAN Length = 296 Score = 275 bits (703), Expect = 2e-72, Method: Composition-based stats. Identities = 77/296 (26%), Positives = 131/296 (44%), Gaps = 24/296 (8%) Query: 39 TTSHYDVGGAAIDNHGQPLPPATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPL 98 V A + + + + L G++ +LPP + L Sbjct: 1 DFEEVHVSSNADEEDIR----NAIMAIRRNRVALKGNIET--NHNLPP---SHKSRNNIL 51 Query: 99 RKHFKLFSNLRPAKLYQGLEAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQY 158 R L++N+ K G+ DIL VRE T G Y E Sbjct: 52 RTSLDLYANVIHWKSLPGVVT--------RHKDIDILIVRENTEGEYSS----LEHESVA 99 Query: 159 EKAFDTEVYHRFEIERIARIAFESARK-RRHKVTSIDKANVLQ-SSILWREIVNEIATEY 216 ++ + + RIA AF+ A++ R KVT++ KAN+++ L+ + E+A Y Sbjct: 100 GVVESLKIITKAKSLRIAEYAFKLAQESGRKKVTAVHKANIMKLGDGLFLQCCREVAARY 159 Query: 217 PDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQG 276 P + +M +DN TMQL+ P QFDV++ NL+G+I+++ CA + G G++ A+ Sbjct: 160 PQITFENMIVDNTTMQLVSRPQQFDVMVMPNLYGNIVNNVCAGLVGGPGLVAGANYGHVY 219 Query: 277 FGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEE 332 + IA KNIANP A +L+ ++L + L A +I +A+ +++ Sbjct: 220 AVFETATRNTGKSIANKNIANPTATLLASCMMLDH-LKLHSYATSIRKAVLASMDN 274 >UniRef50_A9KQX3 Isocitrate dehydrogenase (NAD(+)) n=5 Tax=cellular organisms RepID=A9KQX3_CLOPH Length = 387 Score = 274 bits (700), Expect = 4e-72, Method: Composition-based stats. Identities = 95/370 (25%), Positives = 162/370 (43%), Gaps = 36/370 (9%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQ---PLPP 59 I V GDGIGP + +QA ++L+ + ++ + G I+ +P Sbjct: 40 DKIIIGVCGGDGIGPAITSQAQRILEYLLKDDILQGKVEFKVIDGLTIERRAAEHAAIPA 99 Query: 60 ATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEA 119 ++ ++ +L G P+ P+ + A + +RK LF+N+RP + Sbjct: 100 EVLKELKECHVILKGPTTTPRKGDPWPNVE---SANVAMRKELDLFANVRPVR------- 149 Query: 120 FCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIA 179 I G D RE T G Y KG + D V ERI R A Sbjct: 150 -------IPEQGIDWTFYRENTEGAYAVGSKGIHV--TEDLGVDFTVVTSGGSERIIRAA 200 Query: 180 FESARKRRH-KVTSIDKANVLQS-SILWREIVNEIATEYPDVELAHMYIDNATMQLI--K 235 FE A+ +VT++ KAN++++ + +I EIA +Y D+ YID T +LI K Sbjct: 201 FEYAKANGKTRVTAVTKANIIKTTDGKFLDIFREIAKDYKDITADDWYIDIMTAKLIDEK 260 Query: 236 DPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNI 295 F V++ NL+GDI++DE A G +G SA++ + + ++E GSAP + + Sbjct: 261 RRKDFQVMVLPNLYGDIITDEAAEFQGGVGTAGSANIG-KRYSMFEAIHGSAPRMVQEGR 319 Query: 296 ---ANPIAQILSLALLLRYSLDADDAACAIERAIN--RALEEGIRTGDLARGAAAVSTDE 350 A+P + I + A+LL + + A + +A++ E+ + + + E Sbjct: 320 DQYADPCSVIRAGAMLLAH-IGYGKEADKLYQALDICTVTEKKLV---ITGRNTGATGAE 375 Query: 351 MGDIIARYVA 360 D I + Sbjct: 376 FADYIMETIE 385 >UniRef50_UPI000186E03D isocitrate dehydrogenase, putative n=1 Tax=Pediculus humanus corporis RepID=UPI000186E03D Length = 406 Score = 272 bits (696), Expect = 1e-71, Method: Composition-based stats. Identities = 93/360 (25%), Positives = 153/360 (42%), Gaps = 32/360 (8%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 ++ +L G GIGPE+M L+VL A + I G D + Sbjct: 39 NVTILTGSGIGPEIMDHTLRVLKAAGAPLSYEIFALSSKDGSKNNDF------DEALTSI 92 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 + L G++ L + + RK LF + K + GL Sbjct: 93 RRNRVALKGNI------ELQSKNPHIKSRNIIFRKTLDLFVYILFCKTFPGLSN------ 140 Query: 126 DIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARK 185 DI +R+ T G Y + +G E +V RF +ER+ AF+ A Sbjct: 141 --KFGEIDITVIRQNTEGEYL-MLEHEPRTGSVE---SLKVLTRFNLERLIEFAFDYALT 194 Query: 186 R-RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVL 243 R +T + AN+ + + L+ N+I+ YP +++ + ++ A ++ +P FDV+ Sbjct: 195 NDRKLITVVHNANIQKLTEGLFLNAANKISKSYPMIKMNVLDVNVAIFKIASNPRIFDVI 254 Query: 244 LCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEP-AGGSAPDIAGKNIANPIAQI 302 L +NL G ++S+ + G G+ + + G ++EP A I G N ANPIA I Sbjct: 255 LATNLNGSMISNYLNGMLGGPGLTSGINFSADGIAVFEPGARNKGSSIVGLNRANPIAMI 314 Query: 303 LSLALLLRYSLDADDAACAIERAINRALE-EGIRTGDLARGAAAVSTDEMGDIIARYVAE 361 +S LL + L + A I ++ L + IRT D+ A A +E D I R++ E Sbjct: 315 MSGINLL-HHLGYNKTAEMIHNSVYATLVYDKIRTPDIGGQATA---EETVDHIIRHIRE 370 >UniRef50_UPI000038E0FC 3-isopropylmalate dehydrogenase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI000038E0FC Length = 356 Score = 271 bits (693), Expect = 3e-71, Method: Composition-based stats. Identities = 94/368 (25%), Positives = 165/368 (44%), Gaps = 45/368 (12%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCE 66 IAV+PGDGIG E++ Q ++ ++ + + Y++ N G + + ++ + Sbjct: 4 IAVIPGDGIGKEIIPQVCDLVTSIDP----SVNFTFYNISSERYINKGITIKDSEIDELK 59 Query: 67 QADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRAD 126 +++ FG++G + E+G +L LRK L+ N+RPA + + Sbjct: 60 SYNSIFFGAIG----DFRVKPGIMEQGVILRLRKELDLYMNIRPAISF----------SR 105 Query: 127 IAANGFDILCVRELTGGIYFGQPKG-------------------REGSGQYEKAFDTEVY 167 I N + +RE Y + Sbjct: 106 ITGNNIHMTILRENKEDFYSDISGSLNEHKLFRQKGNFYNYNIDINSESDDTIYYTMGFL 165 Query: 168 HRFEIERIARIAFESARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYID 227 R ++R +A++ A VT DKAN + LWREI E +E ++ Y D Sbjct: 166 SRKNLKRFFNMAYKIADTE--TVTITDKANAVDMYSLWREIAIE-ESEPAGKKINFEYAD 222 Query: 228 NATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSA 287 + +I +P ++ ++ NL+GDILSD + + G +G PS ++ + ++EP GSA Sbjct: 223 SLAYNMINNPLKYRYIIAPNLYGDILSDMSSAMVGGLGYAPSGNIGD-YSSMFEPVHGSA 281 Query: 288 PDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVS 347 PDIAGKNIANP+A ILS ++L++ L+ + A +E+++ + G T + Sbjct: 282 PDIAGKNIANPVASILSCIMMLKH-LNQTETAGIMEKSVENVIRNG--TIPI-ESGGNAG 337 Query: 348 TDEMGDII 355 T E + + Sbjct: 338 THEFINKV 345 >UniRef50_UPI000185C11E 3-isopropylmalate dehydrogenase n=1 Tax=Corynebacterium amycolatum SK46 RepID=UPI000185C11E Length = 394 Score = 271 bits (692), Expect = 3e-71, Method: Composition-based stats. Identities = 115/402 (28%), Positives = 165/402 (41%), Gaps = 69/402 (17%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 I +LPGDGIGPE+ ++ V + + +G + HG P+P T E Sbjct: 14 PRRITLLPGDGIGPEITDACRGLIADVFPHW----ELTETQIGWSQWRAHGNPVPQETWE 69 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPE--------RGALLPLRKHFKLFSNLRPAKLYQ 115 ++DA L ++ + P R +L LR+ LF+N+RP Sbjct: 70 TLGRSDAALLAAITSKPAREAEEELAPHLRGTGLNYRSPVLQLRQRLDLFANIRPV-TLP 128 Query: 116 GLEAFCPLRADIAANGFDILCVRELTGGIYF------------GQPKG------------ 151 G A D VRE T G+Y P Sbjct: 129 GAAA-------------DFTIVRENTEGLYSHDYLLPPHDAPADSPHHHLWAEVVEDSTV 175 Query: 152 -REGSGQYEKAFDTEVYHRFEIERIARIAFESARKRR---------HKVTSIDKANVLQ- 200 R + E A V F R+AR A + A R+ VT DK N+L+ Sbjct: 176 ARAVDKRGEVAVSLRVTTSFAWHRLARQAAKLALARQAANPDSEVTPTVTVADKPNILRD 235 Query: 201 SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMI 260 S+ + R V E+A EYP V D MQL+ DP++FDV++ NL GDILSD A + Sbjct: 236 SARVIRGAVEEVAEEYPQVAFDFANADAVAMQLVTDPARFDVIIAENLIGDILSDIGAGL 295 Query: 261 TGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDA-- 318 G +G+ SA++ + F ++EP GSAPDIAG+ IANP A +LS A+ + Sbjct: 296 IGGLGLAASANVGDN-FAVFEPVHGSAPDIAGRGIANPAAFLLSAAMCAEHLGAPVSELA 354 Query: 319 -ACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYV 359 A + A+ A RT +T E + + Sbjct: 355 PAAKLREAVYAA----TRTAPTLDLGGTATTSEFVAAVRAEL 392 >UniRef50_UPI00016C59BF Isocitrate dehydrogenase (NAD+) n=1 Tax=Gemmata obscuriglobus UQM 2246 RepID=UPI00016C59BF Length = 341 Score = 267 bits (684), Expect = 3e-70, Method: Composition-based stats. Identities = 87/342 (25%), Positives = 149/342 (43%), Gaps = 24/342 (7%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 + + G G+G + ++ A + + + + G A+++ LP AT + Sbjct: 3 KVIFVQGGGLGQDQELSVRRLFAAAK----VPVEFEVHLAGRMALEHGKDALPKATFDAI 58 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGA---LLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 + L + PK +P P + R+ LF+++RP G+ + Sbjct: 59 RECGLALKTKLLQPKGVGMPTAHGPSSVPTNYNVAFRRQLGLFASMRPVHNLPGIPS--- 115 Query: 123 LRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFES 182 G D L RE+T +Y ++ R ++AF++ Sbjct: 116 -----RFTGVDFLLFREITEDLYTASEHEI----VPGVVQSFKIVTEAACLRFFKLAFDT 166 Query: 183 ARKR-RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQF 240 ARKR R V I KAN+L+ + L+ E +A EYP++ + +DN QL+ P QF Sbjct: 167 ARKRGRKTVHCIHKANILKMADGLFLECFYRVAKEYPEIAAKDLIVDNTCNQLVSRPQQF 226 Query: 241 DVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIA 300 +VL NL+GD+LSD A + G + + + G +YE G++ + +++NP+ Sbjct: 227 EVLAAGNLYGDLLSDLGAGLVGGVSTTAAINKGN-GTTVYEAVYGASHEAVPPDMSNPLP 285 Query: 301 QILSLALLLRYSLDADDAACAIERAINRALEEG-IRTGDLAR 341 IL LL+ L A I++A+ L EG IRT D+ Sbjct: 286 LILPAIELLK-DLGETGTAGRIQKAVETVLLEGRIRTRDIGG 326 >UniRef50_C9SEZ4 Homoisocitrate dehydrogenase n=1 Tax=Verticillium albo-atrum VaMs.102 RepID=C9SEZ4_VERA1 Length = 316 Score = 263 bits (673), Expect = 6e-69, Method: Composition-based stats. Identities = 106/361 (29%), Positives = 166/361 (45%), Gaps = 47/361 (13%) Query: 1 MS-KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPP 59 MS + I ++PGDGIG EV+ ++L+A+ + ++ + G + G LP Sbjct: 1 MSIRTLRIGLIPGDGIGKEVIPAGRRILEALPSYLGLKFEFTDLHAGFETFERTGAALPD 60 Query: 60 ATVEGCE-QADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLE 118 TVE + D LFG+V P + ++ LRK L++N+RP K Sbjct: 61 KTVEILRNECDGALFGAVSSPS-----SPVKGYSSPIVALRKKLDLYANVRPVKTV---- 111 Query: 119 AFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARI 178 AA D++ VRE T +Y + R+ + A + RIA + Sbjct: 112 -------LSAAKPIDMVIVRENTEDLYVKEETTRDTPDG-KVAEAIKRISERASHRIATM 163 Query: 179 AFESARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPS 238 A + A RR K+ + ++ QS P V + H N ++L Sbjct: 164 AGDIAL-RRQKIRAAGAPSIHQS---------------PLVTITHK--SNVLLRL----- 200 Query: 239 QFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANP 298 +V++ NL+GDILSD+ A + GS+G++PSA++ +GF + EP GSAPDI G+NIANP Sbjct: 201 -KNVIVDPNLYGDILSDDAAALVGSLGLVPSANVG-EGFAIGEPCHGSAPDIMGQNIANP 258 Query: 299 IAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARY 358 IA + S AL+L + + AA E + + DL T E+ + I R Sbjct: 259 IATLRSAALMLEFLDEEAAAAKIYAAVDANLTEGKLLSPDL---GGTAKTTEVIEDILRR 315 Query: 359 V 359 + Sbjct: 316 L 316 >UniRef50_D2RML7 Isocitrate/isopropylmalate dehydrogenase n=6 Tax=cellular organisms RepID=D2RML7_ACIFE Length = 393 Score = 261 bits (666), Expect = 4e-68, Method: Composition-based stats. Identities = 84/369 (22%), Positives = 152/369 (41%), Gaps = 38/369 (10%) Query: 5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNH---GQPLPPAT 61 + +LPGDGIGP +M QAL+V + + G I+ + LP Sbjct: 47 ITVGILPGDGIGPCIMEQALRVAKYLLKDEMASGKVEFRTIPGMTIEERVQKNESLPAEV 106 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 +E C+ D ++ G P+ P+ LR+ +L++ +RP + Sbjct: 107 LEACKACDVLVKGPFVTPRAGDPWPNMVSANSL---LRRALQLYAAVRPVR--------- 154 Query: 122 PLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFE 181 I G D RE G Y KG + + A D +V R ERI R AFE Sbjct: 155 -----IPEKGIDWTFFRENIEGEYIWGNKGIQVD--DDLAVDFKVLTRPGAERICRAAFE 207 Query: 182 SARKRRHK-VTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKD--P 237 A+ VT + KAN+++ + + + + EYP + + +D+ ++ Sbjct: 208 FAKNNGKTNVTVVTKANIVKLVDGNFLKTAHALEKEYPGITVREELVDSMAAKITDQEFT 267 Query: 238 SQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNI-- 295 V L NL+GDI++D A G +G S+++ +Q + L+E G + N Sbjct: 268 KGMQVFLLPNLYGDIVTDVAAEYQGGLGTASSSNIGDQ-YALFEAIHGVGNFLVQHNRAQ 326 Query: 296 -ANPIAQILSLALLLRYSLDADDAACAIERAIN---RALEEGIRTGDLARGAAAVSTDEM 351 A+P + I ++ ++ + + + + +A++ R + + T D + +E Sbjct: 327 YADPCSLIRAMGEMISH-IGYPEKKEQLVKALDICTRTERKVVITTDKDG----ATAEEF 381 Query: 352 GDIIARYVA 360 D + + Sbjct: 382 TDYLLDTLQ 390 >UniRef50_Q2HAA2 Putative uncharacterized protein n=2 Tax=Chaetomium globosum RepID=Q2HAA2_CHAGB Length = 335 Score = 261 bits (666), Expect = 4e-68, Method: Composition-based stats. Identities = 145/365 (39%), Positives = 200/365 (54%), Gaps = 43/365 (11%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVR--NRFAMRITTSHYDVGGAAIDNHGQPLPPAT 61 ++I V GD GPEV+ +A+KVL A+ + + + +GGA+I H PL Sbjct: 3 THNIVVFGGDHCGPEVVAEAVKVLRAIETHSPSVGKFNLQEHLLGGASIKVHNDPLTAKA 62 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLY-QGLEAF 120 + + ADA+L G++GGP+W P +PE G LL LRK + NLRP L Sbjct: 63 LAAAKAADAILLGAIGGPEWGPSSP-VRPEEG-LLRLRKELGTYGNLRPCNFASDSLVDS 120 Query: 121 CPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAF 180 PL+AD+ G D + VRELTGGIYFG +GSG A DT+ Y R EIERIAR+A Sbjct: 121 SPLKADVC-RGTDFIVVRELTGGIYFGARTEDDGSG---FAMDTDAYSRAEIERIARLAG 176 Query: 181 ESARK--RRHKVTSIDKANVLQSSILWREIVNEI-ATEYPDVELAHMYIDNATMQLIKDP 237 A KV S+DKANVL +S LWR++V E+ A E+P +E+ H ID+A M ++K P Sbjct: 177 FLALGTSPPSKVWSLDKANVLATSRLWRKVVTEVFANEFPQLEVGHQLIDSAAMLMVKSP 236 Query: 238 SQFD-VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIA 296 + V++ SNLFGDI+SDE ++I GS+G I Sbjct: 237 RALNGVVVTSNLFGDIISDEASVIPGSIG---------------------------AGIV 269 Query: 297 NPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIA 356 NPI ILS+A++LRYSL+ A A+E A+ AL+ G RT DL + T +M D + Sbjct: 270 NPIGTILSVAMMLRYSLNLPKEAAAVEAAVRTALDNGTRTKDL---GGSAGTFQMADAVV 326 Query: 357 RYVAE 361 + + Sbjct: 327 VELVK 331 >UniRef50_Q6L0K7 3-isopropylmalate dehydrogenase n=1 Tax=Picrophilus torridus RepID=Q6L0K7_PICTO Length = 335 Score = 259 bits (661), Expect = 2e-67, Method: Composition-based stats. Identities = 91/343 (26%), Positives = 151/343 (44%), Gaps = 44/343 (12%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCE 66 +A++PGDGIG E+M A I +D+ G + +E + Sbjct: 4 VALIPGDGIGREIMPGV-----AAAISSISDINFVTFDISSERYIKTGIIIKDDELEELK 58 Query: 67 QADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRAD 126 A+LFG++G P+ E+G +L LR+ +L+ N+RP + + Sbjct: 59 NYRAILFGAIGDPR----VRPGIMEQGVILRLRRELELYMNIRPVRSFD----------- 103 Query: 127 IAANGFDILCVRELTGGIYFGQPK---------------GREGSGQYEKAFDTEVYHRFE 171 + I +RE T Y +GS E + + Sbjct: 104 ---DKIKITILRENTQDFYTDISGIIPGKRSFNVNGTRIEIDGSSCDEVYYTMGMLSYRY 160 Query: 172 IERIARIAFESARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATM 231 +++ AF VT DKAN ++ LWR E A E ++ ++ Y D Sbjct: 161 LKKFFNKAFSIC---DSTVTVTDKANAVKMYNLWRSTAMEAAIE-KNINISFEYADALAY 216 Query: 232 QLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIA 291 +I +P ++ ++ NL+GDI+SD A + G +G PSA++ ++ L+EP GSAPDIA Sbjct: 217 NMILNPKKYRYIIAPNLYGDIISDMGAALVGGLGYAPSANIGDKN-ALFEPVHGSAPDIA 275 Query: 292 GKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGI 334 G+++ANP A I++ ++LL Y L D + I + G+ Sbjct: 276 GRDMANPAASIMAGSMLLEY-LGYRDESRIINDMVRNLYINGV 317 >UniRef50_C0W9Q2 Isocitrate dehydrogenase n=2 Tax=Clostridiales RepID=C0W9Q2_9FIRM Length = 387 Score = 258 bits (659), Expect = 3e-67, Method: Composition-based stats. Identities = 81/370 (21%), Positives = 157/370 (42%), Gaps = 40/370 (10%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDN---HGQPLPPATV 62 + ++PGDGIGP +M AL V + + + G I+ + LPPA + Sbjct: 39 KVGIMPGDGIGPYIMKAALLVARKLLKKEIADQRVEFVPIKGMTIEERARQNKSLPPAVL 98 Query: 63 EGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 E C+ D ++ G P+ P+ LR+ +L++ +RP + Sbjct: 99 EACKACDILVKGPFVTPRAGDRWPNLLSANSL---LRRQLQLYAAVRPIR---------- 145 Query: 123 LRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFES 182 I G D RE G Y KG + A D ++ + ER+ R AFE Sbjct: 146 ----IPEKGIDWTFFRENIEGEYIWGNKGICVG--DDLAIDFKILSKPGAERLFRNAFEY 199 Query: 183 ARKRRHK-VTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPS-- 238 A+ +T KAN+++ + ++ + + EYP + + ID+ + +L+ DP Sbjct: 200 AKSSGKTNITVATKANIVKLVDGNFLKVAHAMEKEYPGIHVREELIDSLSAKLM-DPEFN 258 Query: 239 -QFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNI-- 295 V + NL+GDIL+D A G +G S+++ +Q + ++E G + N Sbjct: 259 AGMQVFVLPNLYGDILTDIAAEYQGGLGTASSSNIGDQ-YAMFEAIHGVGVYLVEHNRAQ 317 Query: 296 -ANPIAQILSLALLLRYSLDADDAACAIERAIN---RALEEGIRTGDLARGAAAVSTDEM 351 A+P + I ++ ++ + + + + +A++ + + + T D + +E Sbjct: 318 YADPSSLIRAMGEMMAF-IGYPEKRDRLFKALDFCTKVERKAVITTDKDG----ATAEEF 372 Query: 352 GDIIARYVAE 361 + + + + Sbjct: 373 AEYVVETLHK 382 >UniRef50_A9B3D4 Isocitrate/isopropylmalate dehydrogenase n=4 Tax=Bacteria RepID=A9B3D4_HERA2 Length = 246 Score = 257 bits (657), Expect = 5e-67, Method: Composition-based stats. Identities = 71/263 (26%), Positives = 111/263 (42%), Gaps = 38/263 (14%) Query: 5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEG 64 + + ++ GDG GPE+ +VL+A + D G ++ G PLP + +E Sbjct: 3 HRVTLIRGDGTGPELAEATRRVLEA----TGVAFDWDIQDAGVDVMEQLGTPLPDSVLES 58 Query: 65 CEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 L + P R + +RK L++ +RP + Y G+ + Sbjct: 59 IRSTKVALKAPITTPVGTGF-------RSVNVAIRKELDLYACVRPCRSYPGVRS----- 106 Query: 125 ADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEK-----------------AFDTEVY 167 D++ VRE T +Y G R E + Sbjct: 107 ---RFENIDLVVVRENTEDLYAGIEFERGTDEVAELRNWLLQKRPNALIKEPGGISIKPM 163 Query: 168 HRFEIERIARIAFESARKR-RHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMY 225 ERI R AFE AR R KVT++ KAN+++ S L+ E+ E+A EYPD+E Sbjct: 164 SVPGSERIVRFAFEYARANKRKKVTAVHKANIMKFSDGLFLEVAREVAKEYPDIEFDDRI 223 Query: 226 IDNATMQLIKDPSQFDVLLCSNL 248 +DN MQL++ P +DV++ NL Sbjct: 224 VDNMCMQLVQKPELYDVMVLPNL 246 >UniRef50_A6GJ83 Isocitrate dehydrogenase n=1 Tax=Plesiocystis pacifica SIR-1 RepID=A6GJ83_9DELT Length = 344 Score = 257 bits (656), Expect = 5e-67, Method: Composition-based stats. Identities = 87/367 (23%), Positives = 144/367 (39%), Gaps = 36/367 (9%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATV 62 Y I L GDGI E+ V DA+ I D+ + + G + Sbjct: 7 NRYSIVELHGDGIARELSQAVHTVADALP----FEIEFIPVDLSDESREAKGDAIYDEAE 62 Query: 63 EGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 + L + LR+ RP G++ Sbjct: 63 AAMRRYGTSLKYPTAT-----------TKESPNRVLRERCNFAVIHRPVATIPGIQTHYN 111 Query: 123 LRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFES 182 + VR TGG Y + + A R +R AF Sbjct: 112 -------ERIHLDIVRIATGGTYEDAGRRI----NRDTAVSIRAIERRPSVLASRFAFRL 160 Query: 183 ARKRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFD 241 A+ R V + K + + + L++E +A +YP E D +I P ++ Sbjct: 161 AQLRDSNVIATSKYTIQKATDGLFQEAARGVARDYPATEFREELFDALLAGIIMRPERYG 220 Query: 242 VLLCSNLFGDILSDECAMITGSMGMLPSASL-----NEQGFGLYEPAGGSAPDIAGKNIA 296 V++C N +GD LSD + GS+G+ SAS + +++PAGG+APDIAG+N A Sbjct: 221 VIVCPNEYGDFLSDMAYGLIGSIGLGDSASYSFDSQGQVDVAMFDPAGGTAPDIAGQNKA 280 Query: 297 NPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIA 356 NP A +L++A +LR+ + D++ A+ A+ A+E G +T D+ +++ E +I Sbjct: 281 NPTAALLAMANMLRH-IGEHDSSKALRGALFGAIEAGEKTADI---GGSLNLSEFTQVIV 336 Query: 357 RYVAEGV 363 + Sbjct: 337 DRTKSAL 343 >UniRef50_B5RJP2 FI08066p (Fragment) n=18 Tax=Sophophora RepID=B5RJP2_DROME Length = 408 Score = 256 bits (655), Expect = 8e-67, Method: Composition-based stats. Identities = 79/362 (21%), Positives = 150/362 (41%), Gaps = 41/362 (11%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPAT 61 K + ++ G+G+G E+M +V+ AV+ I +D + P Sbjct: 84 KKTTKVTLINGEGVGRELMDAVQEVICAVKA----PIEWDVHD---EFKAKDSDDVSPEV 136 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 ++ + G V W+ +RK F F+ + +GL++ Sbjct: 137 LKSLRANKVGIKGPVDSRHWQR-------------QIRKQFAQFAYVSLCSHIEGLDSPY 183 Query: 122 PLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFE 181 FD++ +R+ G Y G E +V RIA F Sbjct: 184 --------GDFDVVIIRDQMEGDYSG----IEHLVVPGVMQTIKVSTTAGAARIAEFVFN 231 Query: 182 SARKR-RHKVTSIDKANVLQ-SSILWREIVNEIATEY-PDVELAHMYIDNATMQLIKDPS 238 A K R ++T KAN+++ + + E + A ++ DV Y+D ++++ P Sbjct: 232 YAVKNKRKRITVAHKANIMRMTDGNFLEAMRAEADKHVDDVLFEERYLDTCILKILLKPH 291 Query: 239 QFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANP 298 + DV++ S+++GD+L + G G+ P S++ G +++ + +AGK++ANP Sbjct: 292 KCDVMVSSSMYGDVLRVIAGGMMGVPGICPGYSVSSLGT-VFDCRMKACHALAGKDLANP 350 Query: 299 IAQILSLALLLRYSLDADDAACAIERAINRALEE-GIRTGDLARGAAAVSTDEMGDIIAR 357 +LS AL+LR+ + D A ++ AI + ++ IRT D+ E + Sbjct: 351 TGPLLSAALMLRH-VKMDKQADQVDCAIRKVYKDTDIRTPDV---GGKAKCSEFVKAVCD 406 Query: 358 YV 359 + Sbjct: 407 CL 408 >UniRef50_B8FQF2 Isocitrate/isopropylmalate dehydrogenase n=2 Tax=Desulfitobacterium hafniense RepID=B8FQF2_DESHD Length = 374 Score = 254 bits (648), Expect = 5e-66, Method: Composition-based stats. Identities = 112/376 (29%), Positives = 163/376 (43%), Gaps = 31/376 (8%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRN-RFAMRITTSHYDVGGAAIDNHGQPLPPAT 61 K Y IAV+P DG+G +V+ K + + + +Y+ G G+ Sbjct: 2 KKYTIAVIPLDGVGKDVIPLGAKAMQKAQEILGGFELDCRYYEAGVEYAVKTGKMCEDNL 61 Query: 62 VEGCEQADAVLFGSVGGPKWEHLP---PDQQPERGALLPLRKHFKLFSNLRPAKLYQGLE 118 E +ADA+L GS G + P + L LR LRP +L +G++ Sbjct: 62 GEDIAKADAMLCGSAGHYDADMSKSEYPGYKTGMQVLQFLRSGMGNSIGLRPLRLRKGID 121 Query: 119 AFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARI 178 R D+L VR+L G Y +P G + A+DT V R E+ A Sbjct: 122 CPLRNR-----EEIDVLLVRQLAEGFYI-RPGHMIG---EDAAYDTIVVTRNVTEKFADT 172 Query: 179 AFESARKR-------RHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATM 231 F AR R + VT +K + +R+I E++ YPD+ L +D Sbjct: 173 CFRLARGRHGRRQDGKKMVTLGNKHGNVTCFDFYRKIFTEVSAGYPDIGLQFTQVDALAE 232 Query: 232 QLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIA 291 LIKDP +FDV+ C N+ GDI+ D A ITG MG+ P+A + + P G+ P Sbjct: 233 HLIKDPDRFDVIACENMIGDIIGDIGAYITGGMGITPTADVGGVTP-QFRPNHGTFPRAV 291 Query: 292 GKNIANPIAQILSLALLLRYSL------DADDAACAIERAINRALEE-GIRTGDLARGAA 344 GK ANP+A IL+ LLL + A IE+A+ L G RT DL A Sbjct: 292 GKGFANPLASILTAGLLLDTLGNERGDDNLRRGARLIEKAVEYNLTTGGPRTKDLGGTAN 351 Query: 345 AVSTDEMGDIIARYVA 360 +T E + + + Sbjct: 352 TFATAE---AVFKAME 364 >UniRef50_B7KHW3 Isocitrate/isopropylmalate dehydrogenase n=11 Tax=Bacteria RepID=B7KHW3_CYAP7 Length = 363 Score = 245 bits (625), Expect = 2e-63, Method: Composition-based stats. Identities = 86/373 (23%), Positives = 142/373 (38%), Gaps = 28/373 (7%) Query: 1 MSKN-YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPP 59 M++ I V+ GD G E++ QAL+VL + + YD+ + Sbjct: 1 MTQTTPTIVVMHGDQTGEELLIQALRVLQ--PSVIRQPLQFLDYDLSLENRRATDNKVVW 58 Query: 60 ATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEA 119 + + L + P+ LR+ LR + + Sbjct: 59 EAAQAARDSGLSLKAATITPEIAGDV------GSPNAILREALNAKVILRTGRRIPKIRP 112 Query: 120 FCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIA 179 + + I VR Y + E A+ T R +A Sbjct: 113 IAGVYSP-------IAIVRMAVDDAYGSKEWRETTENGDEIAYRTSKISRSTCRAVAEFT 165 Query: 180 FESARKRRHKVTSIDKANVLQS-SILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPS 238 F+ A++ + KV K V + +++E ++ A YP+V + ID L++ Sbjct: 166 FQYAKRTKAKVFGGPKFTVSATYEGMFKEELDAAAKRYPEVPYQPLLIDATFALLLQTTG 225 Query: 239 QFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQG------FGLYEPAGGSAPDIAG 292 + V+ N GD+LSD + GS+ S L + + E G+AP + G Sbjct: 226 ESLVIPALNRDGDLLSDMVLQMYGSIAGSESLVLGFESGSDQVKTVMAEAPHGTAPALFG 285 Query: 293 KNIANPIAQILSLALLLRY--SLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDE 350 KNIANP+A IL+ A LL Y A+ A+ AI ++ + EG T DL ++T E Sbjct: 286 KNIANPMAMILAGAALLSYGRIPQAEKASRAIYESVFETIYEGKATPDL---GGQMTTSE 342 Query: 351 MGDIIARYVAEGV 363 D + R V + Sbjct: 343 FTDEVIRRVETKL 355 >UniRef50_UPI00017936A6 PREDICTED: similar to isocitrate dehydrogenase, NAD-dependent n=1 Tax=Acyrthosiphon pisum RepID=UPI00017936A6 Length = 423 Score = 239 bits (610), Expect = 1e-61, Method: Composition-based stats. Identities = 76/377 (20%), Positives = 145/377 (38%), Gaps = 42/377 (11%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATV 62 + + V+ G G GP V+ K+ A T + P + Sbjct: 39 RPIRVTVIEGQGTGPVVLAAVRKIFKAALVPVEWDYQTLSVYRDHKTNRMT---VNPQLL 95 Query: 63 EGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 + + VL P+ L L K F +R G E + P Sbjct: 96 DSAIETGLVLCAKDSSPRQND------SLESDSLALHKALNAFVGVRKFNSVVGHEPYGP 149 Query: 123 LRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFES 182 +++ +RE G Y E + + +A++AF+ Sbjct: 150 ---------INLVNIREHVSGEYS----EIEHLVSPGVVQSIKTVSKKISVEVAKLAFDY 196 Query: 183 ARKRRH-KVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQF 240 A K H ++T + KA+V++ S ++ + E++ YPDVE +D+ + + +P ++ Sbjct: 197 ACKHGHSRITVLHKADVMRLSDGIFLKACREVSACYPDVEYNEEKLDSFCLNVTTNPGRY 256 Query: 241 DVLLCSNLFGDILSDECAMITGSMGMLPS----------ASLNEQGFGLYEPAGGSA--- 287 +VLL ++L+G C M++G + +P+ +++ + G+ Y + G Sbjct: 257 EVLLTTSLYGAFAGSVCGMMSGGLVTVPTIAYGPKATVFSTMGDYGYSTYSHSDGDGIFK 316 Query: 288 PDIAGKN-IANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAV 346 + G+ I NP I + AL+L + A I A+ + +GIRT D+ Sbjct: 317 KMVYGQEQIINPTGIIRAAALMLDH-AGMVVAGRCIAAAVEDTIRQGIRTQDM---GGDA 372 Query: 347 STDEMGDIIARYVAEGV 363 S + D I + + + + Sbjct: 373 SCSQFTDAIIKNLKDSM 389 >UniRef50_D2SD16 Malate/L-lactate dehydrogenase n=1 Tax=Geodermatophilus obscurus DSM 43160 RepID=D2SD16_9ACTO Length = 732 Score = 235 bits (599), Expect = 3e-60, Method: Composition-based stats. Identities = 112/366 (30%), Positives = 166/366 (45%), Gaps = 27/366 (7%) Query: 5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEG 64 +A+LPGDG+G EV+ ++L + R + +T + VG A G LP T+ Sbjct: 2 IRVALLPGDGVGEEVLDGPTRLLRLLAERGEVEVT-GPWPVGARAAAETGDVLPAGTLAA 60 Query: 65 CEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 C+ ADA+L G+VG +PE AL LR+ + L ++R G E Sbjct: 61 CDAADAILLGAVGEDPRVPAGVCPRPEV-ALHRLRERYDLRISVREIPFADGRE------ 113 Query: 125 ADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFE-SA 183 + VR L GG Y G E A D R + + A + Sbjct: 114 ---------LTVVRNLIGGSYGGADDRVLREDGSEAA-DVLRLTRERVAEVVHTACDVLG 163 Query: 184 RKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVL 243 R+ ++ S+DKAN+ + LWR++ ++A E +E+ H Y+D A +L DVL Sbjct: 164 RRGGGRLVSVDKANLYATGRLWRQVAGDVARER-GIEVEHRYVDRAAFELGSGAPVPDVL 222 Query: 244 LCSNLFGDILSDECAMITGSMGMLPSASLNE------QGFGLYEPAGGSAPDIAGKNIAN 297 + L GDILSD A GS + SASL+ + GL+EPA GSAP A ++ + Sbjct: 223 VTEGLLGDILSDLAAGRAGSPALCGSASLHPGEPVRGRCVGLFEPAHGSAPRRALRDQVD 282 Query: 298 PIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAA-AVSTDEMGDIIA 356 P+ L+LA LLR+ +A + A+ L G T DL A ST ++ D + Sbjct: 283 PLGGFLALAALLRHFPATREAGERVRAAVGAVLRSGPWTYDLVPEGGAAASTGQVADAVL 342 Query: 357 RYVAEG 362 G Sbjct: 343 AAFGSG 348 >UniRef50_B4MP27 GK19462 n=1 Tax=Drosophila willistoni RepID=B4MP27_DROWI Length = 390 Score = 234 bits (598), Expect = 3e-60, Method: Composition-based stats. Identities = 77/326 (23%), Positives = 133/326 (40%), Gaps = 36/326 (11%) Query: 19 VMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCEQADAVLFGSVGG 78 ++ +KV V+ + H G+ + P +E + + G Sbjct: 1 MIESLVKVFSTVQVPIDWDVFHEHKINSAE-----GEDVSPKLLESLCRNKIGIKGPFES 55 Query: 79 PKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRADIAANGFDILCVR 138 L LRK F+LF+ + + +G + D L +R Sbjct: 56 GP-------------CLRKLRKKFQLFAFVAVCRNLEG--------QNTRYGKLDCLIIR 94 Query: 139 ELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARKR-RHKVTSIDKAN 197 + G Y G +V +R+AR FE A+K R K+T KAN Sbjct: 95 DQVEGEYSGIEHRV----VPGVMQTIKVSTAEGADRMARYVFEYAKKNNRKKITVAHKAN 150 Query: 198 VLQ-SSILWREIVNEIATEY-PDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSD 255 +++ + + + A +Y D+ Y+D + ++ P + DVL+ S+++GD+L+ Sbjct: 151 IMRLTDGTFLSPMRREAAKYQDDIMFEERYLDTVCLAMLMKPERKDVLVASSMYGDVLTF 210 Query: 256 ECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDA 315 A I G + P ++ G +YEP + +IAGK+I NP +LS L+LR + Sbjct: 211 MAASIMGGPALCPGFAVGPMGL-IYEPIIHTNTNIAGKDIVNPTGMLLSGVLMLR-EMKL 268 Query: 316 DDAACAIERAINRALEE-GIRTGDLA 340 ++ A I A++ E RT DL Sbjct: 269 NEYADKICCAVSTVFRETDCRTKDLG 294 >UniRef50_UPI0001C31665 isocitrate/isopropylmalate dehydrogenase n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C31665 Length = 368 Score = 232 bits (593), Expect = 1e-59, Method: Composition-based stats. Identities = 86/377 (22%), Positives = 142/377 (37%), Gaps = 33/377 (8%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPA 60 M + I +L GD G E++ QA++VLD + + +D+ + Sbjct: 1 MPEPLKITILEGDETGQELLDQAVRVLD--PEVTGLPLELERFDLSLENRRATQNGVVSD 58 Query: 61 TVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAF 120 + + P+ LR+ +R + G+ Sbjct: 59 AAAAMRTCGFGIKAATITPEGADDV------GSPNRILREEVDGKVIVRTGRRIPGV--- 109 Query: 121 CPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQ--YEKAFDTEVYHRFEIERIARI 178 IA + I VR Y G + REG E A+ TE R ++ Sbjct: 110 ----TPIAGVHYPISIVRMAIEDAY-GAKQWREGDAGAADEVAYRTEHVTRSTCRAVSEY 164 Query: 179 AFESARKRRHKVTSIDKANVLQ-SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDP 237 AF +AR + +V K V + +E ++ A +PDV + ID L+ Sbjct: 165 AFRTARAMQARVYGGPKWTVSPVYEGMLKEEMDAAAARHPDVAYEPVLIDATYAGLVSGA 224 Query: 238 SQFD-VLLCSNLFGDILSDECAMITGSMGMLPSASLN-----EQGFGLYEPAGGSAPDIA 291 + V+ N GD LSD + GS+ S L E + E G+AP + Sbjct: 225 ADEPLVVPALNRDGDCLSDLVLPMFGSIAGAESVLLAFDDNYETHVAMAEAPHGTAPALR 284 Query: 292 GKNIANPIAQILSLALLLRY-----SLDADDAACAIERAINRALEEGIRTGDLARGAAAV 346 GK++ANP+A +L+ +LR+ A+ A+ AI ++ A+ GI+T DL Sbjct: 285 GKDVANPMAMLLASGAVLRHAAERGHPGAERASRAIYESVLEAIATGIKTPDL---GGHA 341 Query: 347 STDEMGDIIARYVAEGV 363 T E D + + + Sbjct: 342 GTTEFTDAVIERITTKI 358 >UniRef50_Q961P4 GH13226p n=4 Tax=Drosophila RepID=Q961P4_DROME Length = 307 Score = 230 bits (588), Expect = 5e-59, Method: Composition-based stats. Identities = 74/344 (21%), Positives = 139/344 (40%), Gaps = 41/344 (11%) Query: 20 MTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCEQADAVLFGSVGGP 79 M +V+ AV+ I +D + P ++ + G V Sbjct: 1 MDAVQEVICAVKA----PIEWDVHD---EFKAKDSDDVSPEVLKSLRANKVGIKGPVDSR 53 Query: 80 KWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRADIAANGFDILCVRE 139 W+ +RK F F+ + +GL++ FD++ +R+ Sbjct: 54 HWQR-------------QIRKQFAQFAYVSLCSHIEGLDSPY--------GDFDVVIIRD 92 Query: 140 LTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARKR-RHKVTSIDKANV 198 G Y G E +V RIA F A K R ++T KAN+ Sbjct: 93 QMEGDYSG----IEHLVVPGVMQTIKVSTTAGAARIAEFVFNYAVKNKRKRITVAHKANI 148 Query: 199 LQ-SSILWREIVNEIATEY-PDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDE 256 ++ + + E + A ++ DV Y+D ++++ P + DV++ S+++GD+L Sbjct: 149 MRMTDGNFLEAMRAEADKHVDDVLFEERYLDTCILKILLKPHKCDVMVSSSMYGDVLRVI 208 Query: 257 CAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDAD 316 + G G+ P S++ G +++ + +AGK++ANP +LS AL+LR+ + D Sbjct: 209 AGGMMGVPGICPGYSVSSLGT-VFDCRMKACHALAGKDLANPTGPLLSAALMLRH-VKMD 266 Query: 317 DAACAIERAINRALEE-GIRTGDLARGAAAVSTDEMGDIIARYV 359 A ++ AI + ++ IRT D+ E + + Sbjct: 267 KQADQVDCAIRKVYKDTDIRTPDV---GGKAKCSEFVKAVCDCL 307 >UniRef50_B0BZF3 Isocitrate dehydrogenase NAD-dependent n=1 Tax=Acaryochloris marina MBIC11017 RepID=B0BZF3_ACAM1 Length = 348 Score = 230 bits (587), Expect = 6e-59, Method: Composition-based stats. Identities = 91/359 (25%), Positives = 151/359 (42%), Gaps = 52/359 (14%) Query: 5 YHIAVL-PGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 Y + ++ G E+ Q L + IT D+GG D G LP + Sbjct: 3 YPVVLIQEG-----ELGAQVTNALQMAIAATGVDITWQIVDIGGE--DQQG-LLPNYIFD 54 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 A + G + P +R+ L+ NLRPAK G+ + Sbjct: 55 IIRTAKTAVIGPLMMPDNYRQMEAD---------IREKLDLYVNLRPAKTMVGIPSNY-- 103 Query: 124 RADIAANGFDILCVRELTGGIYFGQPKGREGSGQ----------------YEKAFDTEVY 167 DI+ VRE T GIY G R + A + Sbjct: 104 ------QNVDIMIVRETTEGIYAGIEFERTSVEAADARSFLSKLSGKRIREDAAVGIKPI 157 Query: 168 HRFEIERIARIAFESARK-RRHKVTSIDKANVL-QSSILWREIVNEIATEYPDVELAHMY 225 +I AF ARK +RH+V ++ +A+ + + L+ EI +IA E+PD+ A Sbjct: 158 SVKGCGQIIEFAFNYARKTKRHQVIAVHQAHFMAHTDGLFLEIARDIAQEFPDIAFADRS 217 Query: 226 IDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGG 285 I+ +L++ P +FDVL+ NL+GD+L+ CA + G + + P A + ++ + ++ A Sbjct: 218 IEVICQELMQKPERFDVLVMPNLYGDLLAHLCAGMVGGLSV-PIAHVGDK-YAVF-GAQS 274 Query: 286 SAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGI-RTGDLARGA 343 + D G + P + IL+ AL+LR+ L +AA ++ A+ + + T DL Sbjct: 275 TGTDDVGHD---PTSLILAGALMLRH-LGEQEAAQRLQAAVEAVVASHVDTTADLNPVG 329 >UniRef50_C5GTE7 Tartrate dehydrogenase n=2 Tax=Ajellomyces dermatitidis RepID=C5GTE7_AJEDR Length = 307 Score = 229 bits (585), Expect = 1e-58, Method: Composition-based stats. Identities = 90/334 (26%), Positives = 150/334 (44%), Gaps = 49/334 (14%) Query: 5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRI--TTSHYDVGGAAIDNHGQPLPPATV 62 Y IA + GDGIGPEV+ NR A + S G I + + P Sbjct: 16 YKIAAIRGDGIGPEVIEAGNYQSAEETNRVAWILLNWPSRTLSGAVRITRNTADISP--- 72 Query: 63 EGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 + + F + LPLR SN+ P +++ G+++ Sbjct: 73 --ISSSTFLWF-------------------SSYLPLRSS---TSNM-PTRVFHGIQSPL- 106 Query: 123 LRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFES 182 D + VRE + G Y G +E A D ++ R +ERI + AFE+ Sbjct: 107 --------HLDWVIVRENSEGEYAGHGGRSYAGKPWEVATDISIFTRHGVERIMKFAFEA 158 Query: 183 ARKR-RHKVTSIDKANVLQSS-ILWREI-VNEIATEYPDVELAHMYIDNATMQLIKDPSQ 239 AR R + +T K+N ++ ++W EI E+A ++PDV M +D T +++ P Sbjct: 159 ARSRAKKHITVATKSNAQRNGLVVWDEIAAAEVAAQFPDVTCDKMLVDAMTARVVLTPES 218 Query: 240 FDVLLCSNLFGDILSDECAMITGSMGMLPSASLNE--QGFGLYEPAGGSAPDIAGKNIAN 297 D ++ +NL ILSD + + GS+G+ P+++L+ + ++EP GSA DIAGK+ Sbjct: 219 LDTIVPTNLHAGILSDLASALAGSIGIAPTSNLDPTRENPSMFEPVHGSAFDIAGKD--- 275 Query: 298 PIAQILSLALLLRYSLDADDAACAIERAINRALE 331 +A ++A +L + AA +E + + Sbjct: 276 -LATFWTVAEMLSWLGQKGAAAELLEC-VESVCK 307 >UniRef50_C7YX79 Putative uncharacterized protein (Fragment) n=1 Tax=Nectria haematococca mpVI 77-13-4 RepID=C7YX79_NECH7 Length = 352 Score = 226 bits (577), Expect = 7e-58, Method: Composition-based stats. Identities = 116/358 (32%), Positives = 171/358 (47%), Gaps = 32/358 (8%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRN-RFAMRITTSHYDVGGAAIDNHGQPL-PPA 60 + + +A+LPGDG GP + + + LD ++ R + S +D GG A+ P Sbjct: 8 RPFQVALLPGDGQGPYLASYVERTLDLIQRVRRNVSFKVSRHDFGGVALAAGAGTALPST 67 Query: 61 TVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAF 120 T+ C Q+DAVL G P++ +PERG LL LR+ + N+RP + Sbjct: 68 TLGACRQSDAVLVCGCGDPRYG-----IEPERG-LLTLRQELEGCVNIRPVRFPSSQLVQ 121 Query: 121 CPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAF 180 DI R+LT G+Y+G+ K G+ A+DT Y R IERIAR+A Sbjct: 122 QSSYKPEVVEQLDITFFRDLTSGVYYGRRKEAGDDGE---AYDTTPYSRQTIERIARLAG 178 Query: 181 ESARK--RRHKVTSIDKANVLQSSILWREIVNEI-ATEYPDVELAHMYIDNATMQLIKDP 237 A + V SIDK NV+ +S LWR +V + E+P V L H+ +D A+M L DP Sbjct: 179 TYAMQFSPPKPVHSIDKHNVMATSRLWRSVVAHVFENEFPQVPLRHVLVDTASMILSSDP 238 Query: 238 SQFD-VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDI------ 290 + ++L N+FGDILSD+ I GS +L SA+++ + P I Sbjct: 239 LSLNGIILTENMFGDILSDQAGGILGSPDVLASAAVS----AIRRGGSRGTPGIFEPFNL 294 Query: 291 -AGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALE------EGIRTGDLAR 341 G P+ I ++ L+L SL + A+ +AI R L+ RT DL Sbjct: 295 NPGGKTVGPLGSIQAVGLMLELSLGLAAESEALSKAIRRTLDPIELVGSDTRTVDLGG 352 >UniRef50_B1VH60 Putative dehydrogenase n=1 Tax=Corynebacterium urealyticum DSM 7109 RepID=B1VH60_CORU7 Length = 378 Score = 223 bits (569), Expect = 7e-57, Method: Composition-based stats. Identities = 99/350 (28%), Positives = 161/350 (46%), Gaps = 22/350 (6%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLD-AVRNRFAMRITTSHYDVGGAAIDNHGQPLPPA 60 ++ + V G+GIGPE++ ++ ++ A++ +G AI+ G+ +P Sbjct: 4 TETCRLGVWQGEGIGPEIVAPTVQAVELALQASGEATPEFVPLLLGREAINATGRIVPEE 63 Query: 61 TVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAF 120 T E D + G PP + LRK L++N+RP + G Sbjct: 64 TWETITGLDGWILGPH---DNVSYPPSVAGQLNPSAHLRKQADLWANIRPVRGVPG---- 116 Query: 121 CPLRADIAANGFDILCVRELTGGIYFGQP---KGREGSGQYEKAFDTEVYHRFEIERIAR 177 D++ VRE T G+Y + + + E + V+ + +I RI R Sbjct: 117 ------AVHPDLDVVIVRENTEGMYADRNMLMGSGDITVNGEVSLAIGVFTQTKIRRIVR 170 Query: 178 IAFESARKRRHKVTSIDKANVL-QSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKD 236 A A R +T K+NVL ++S + A E+ VE+ ++ID +L+ Sbjct: 171 RAAAIAAARDGVLTVAHKSNVLTETSGRYVAEAKACAEEF-GVEVQPVHIDALCAELVTR 229 Query: 237 PSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIA 296 P ++ ++ N+FGDILSD + GS+G+ S + + + + + A GSAPDIAG+ IA Sbjct: 230 PERYATIVAENMFGDILSDLAGGLGGSLGIAGSINAS-ESQVMAQAAHGSAPDIAGQGIA 288 Query: 297 NPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAV 346 NP + S A +L SL AA +E A+ A+ T DL R AAA Sbjct: 289 NPAGIMNSAAQMLD-SLGYPQAAELLEGAVREAVV-KAPTADLVREAAAA 336 >UniRef50_A4FEJ6 3-isopropylmalate dehydrogenase n=1 Tax=Saccharopolyspora erythraea NRRL 2338 RepID=A4FEJ6_SACEN Length = 407 Score = 220 bits (560), Expect = 8e-56, Method: Composition-based stats. Identities = 93/257 (36%), Positives = 129/257 (50%), Gaps = 20/257 (7%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCE 66 IAV+PGDGIGPE++ A++VL A R + + + D G A G + AT+E Sbjct: 9 IAVIPGDGIGPELVRSAVEVLRAAAGR-DVELRFTSEDAGADAFRRTGSAMSAATLERIR 67 Query: 67 -QADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 + VL G VG P H PD LR ++N+RP L G++A Sbjct: 68 TRYHGVLKGPVGLPGVRH--PDGTEAGLLGGVLRGGLDTYANVRPIALLPGVDAP----- 120 Query: 126 DIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARK 185 + D + VRE T G+Y + + G G D + R +ER+ AFE A + Sbjct: 121 -LRGTAVDYVIVRENTEGLYLSRGR---GVGNDRACADQLLMTRHGVERVVVHAFELATR 176 Query: 186 RR-------HKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPS 238 R +VT +DK+NVL+S +RE+ +E+AT YP VE H Y D A L+ DP Sbjct: 177 RTGAPADGVRRVTCVDKSNVLRSFAFFREVFDEVATRYPQVEADHRYADAAGHDLVADPG 236 Query: 239 QFDVLLCSNLFGDILSD 255 +FDVL+ N GDILSD Sbjct: 237 RFDVLVMENFLGDILSD 253 >UniRef50_O75874 Isocitrate dehydrogenase [NADP] cytoplasmic n=362 Tax=cellular organisms RepID=IDHC_HUMAN Length = 414 Score = 215 bits (547), Expect = 3e-54, Method: Composition-based stats. Identities = 75/421 (17%), Positives = 135/421 (32%), Gaps = 70/421 (16%) Query: 1 MSKNYH---IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPL 57 MSK + + GD E+ +++ + + YD+G D + Sbjct: 1 MSKKISGGSVVEMQGD----EMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQV 56 Query: 58 PPATVEGCEQADAVLFGSVGGPKWEHLPPD--QQPERGALLPLRKHFKLFSNLRPAKLYQ 115 E ++ + + + P + + +Q + +R R A + + Sbjct: 57 TKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTV-FREAIICK 115 Query: 116 GLEAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHR------ 169 + I+ R G Y G G+ E + + Sbjct: 116 NIPRLVSGWVKP------IIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLV 169 Query: 170 -----------------FEIERIARIAFESARKRRHKVTSIDKANVL-QSSILWREIVNE 211 IE A +F+ A + + K +L + +++I E Sbjct: 170 HNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQE 229 Query: 212 IA-TEYP------DVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSM 264 I +Y + H ID+ Q +K F + C N GD+ SD A GS+ Sbjct: 230 IYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGF-IWACKNYDGDVQSDSVAQGYGSL 288 Query: 265 GMLPSASLNEQGFGLY-EPAGGSAPDIA------GKNIANPIAQILSLALLLRYSLDADD 317 GM+ S + G + E A G+ + NPIA I + L + D+ Sbjct: 289 GMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDN 348 Query: 318 ------AACAIERAINRALEEGIRTGDLA---------RGAAAVSTDEMGDIIARYVAEG 362 A A+E +E G T DLA + + ++T E D + + Sbjct: 349 NKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIK 408 Query: 363 V 363 + Sbjct: 409 L 409 >UniRef50_UPI00003C8595 isocitrate dehydrogenase n=1 Tax=Ferroplasma acidarmanus fer1 RepID=UPI00003C8595 Length = 377 Score = 215 bits (547), Expect = 3e-54, Method: Composition-based stats. Identities = 75/378 (19%), Positives = 149/378 (39%), Gaps = 44/378 (11%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRF---AMRITTSHYDVGGAAIDNHGQPLP 58 I + GDGIGPE+ + V+++ + I +G A + G +P Sbjct: 21 PDILTIGYIDGDGIGPEITGAMIGVVNSAIELAYQGSRSIEWHKILIGTEAYEKFGTYVP 80 Query: 59 PATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLE 118 +++ ++ + ++ + PD+ R LRK L+SN+R K +G++ Sbjct: 81 EDSIKEIQKMYIAMKSTL------NFMPDK---RDLNTILRKRLGLYSNIRILKYIEGMD 131 Query: 119 AFCPLRADIAANGFDILCVRELT--GGIYFGQPKGREG-----------SGQYEKAFDTE 165 N ++ +R+ T I++ + + + + Sbjct: 132 IPVN-----TFNRLNLTIIRDSTPNSHIFYHSSESTDDLIRFISDNYGLNITPDSGIYMM 186 Query: 166 VYHRFEIERIARIAFESARKRRHKVTSIDKANVLQSS--ILWREIVNEIATEYPDVELAH 223 +F +IA+ A +R+ K K +L+S + E A+ DV Sbjct: 187 PQSKFRTRKIAKQAVRYSRRNGKK-----KITILESQQNHEFANWCIEEASAQEDVGYEV 241 Query: 224 MYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPA 283 + +LI P F+V+L N+ L D + G++ + +S+ ++ ++E Sbjct: 242 LKTREFMKRLISSPEDFEVILVDNVLSQTLVDY---LAGTINIEYGSSIGDEC-AVFEAV 297 Query: 284 GGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDL--AR 341 S P AG + A+P++ ILS +L + + +AA IE AI+ A + D+ Sbjct: 298 QSSLPSEAGYDAADPLSFILSGCEMLMH-IGWVEAAQIIENAISAAFRDNKIPKDINTRP 356 Query: 342 GAAAVSTDEMGDIIARYV 359 + + E I + + Sbjct: 357 DISPIKCSEFSSEIIKRM 374 >UniRef50_P50217 Isocitrate dehydrogenase [NADP] n=49 Tax=cellular organisms RepID=IDHC_SOLTU Length = 416 Score = 213 bits (543), Expect = 7e-54, Method: Composition-based stats. Identities = 68/412 (16%), Positives = 126/412 (30%), Gaps = 67/412 (16%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCE 66 I + GD E+ K + + + ++ +G D + + E + Sbjct: 12 IVEMDGD----EMTRVIWKSIKDKLILPFLELDIKYFSLGLPHRDATDDKVTVESAEATQ 67 Query: 67 QADAVLFGSVGGPKWEHLPPDQQP--ERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 + + + + P + R +R P + + P Sbjct: 68 KYNVAIKCATITPDEARVKEFNLKSMWRSPNGTIRNILNGTVFREPIMC-KNIPRLVPGW 126 Query: 125 ADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKA----------------------F 162 I R G Y +G+G+ + Sbjct: 127 TKP------ICIGRHAFGDQYRATDTVIKGAGKLKLVFVPEGSDEKTEFEVYNFTGAGGV 180 Query: 163 DTEVY-HRFEIERIARIAFESARKRRHKVTSIDKANVL-QSSILWREIVNEIAT------ 214 +Y + A + A +++ + K +L + +++I E+ Sbjct: 181 ALSMYNTDESVRSFAEASMNMAFQKKWPLYLSTKNTILKKYDGRFKDIFQEVYEANWKSK 240 Query: 215 -EYPDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLN 273 E + H ID+ +K + V C N GD+ SD A GS+G++ S + Sbjct: 241 YEEAGIWYEHRLIDDMVAYALKSEGGY-VWACKNYDGDVQSDFLAQGFGSLGLMTSVLVC 299 Query: 274 EQGFGLY-EPAGGSAPDIA------GKNIANPIAQILSLALLLRYSLDAD------DAAC 320 G + E A G+ G+ N IA I + L + D D Sbjct: 300 PDGKTIEAEAAHGTVTRHYRVHQKGGETSTNSIASIFAWTRGLAHRATLDNNERLLDFTE 359 Query: 321 AIERAINRALEEGIRTGDLA---------RGAAAVSTDEMGDIIARYVAEGV 363 +E A A+E G T DLA ++T+E D +A + + Sbjct: 360 KLEAACIGAVESGKMTKDLALIIIHGSKLSREHYLNTEEFIDAVADELKARL 411 >UniRef50_P48735 Isocitrate dehydrogenase [NADP], mitochondrial n=656 Tax=cellular organisms RepID=IDHP_HUMAN Length = 452 Score = 211 bits (538), Expect = 3e-53, Method: Composition-based stats. Identities = 68/412 (16%), Positives = 131/412 (31%), Gaps = 67/412 (16%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCE 66 + + GD E+ + + + I ++D+G D + + + Sbjct: 50 VVEMDGD----EMTRIIWQFIKEKLILPHVDIQLKYFDLGLPNRDQTDDQVTIDSALATQ 105 Query: 67 QADAVLFGSVGGPKWEHLPPD--QQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 + + + P + ++ + +R P + + P Sbjct: 106 KYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIIC-KNIPRLVPGW 164 Query: 125 ADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTE---------VY-------- 167 I R G Y + +G ++ F + VY Sbjct: 165 TKP------ITIGRHAHGDQYKATDFVADRAGTFKMVFTPKDGSGVKEWEVYNFPAGGVG 218 Query: 168 -----HRFEIERIARIAFESARKRRHKVTSIDKANVLQS-SILWREIVNEIATEY----- 216 I A F+ A +++ + K +L++ +++I EI ++ Sbjct: 219 MGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFDKHYKTDF 278 Query: 217 --PDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNE 274 + H ID+ Q++K F V C N GD+ SD A GS+G++ S + Sbjct: 279 DKNKIWYEHRLIDDMVAQVLKSSGGF-VWACKNYDGDVQSDILAQGFGSLGLMTSVLVCP 337 Query: 275 QGFGLY-EPAGGSAPDIAGKNI------ANPIAQILSLALLLRYSLDAD------DAACA 321 G + E A G+ ++ NPIA I + L + D A Sbjct: 338 DGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQM 397 Query: 322 IERAINRALEEGIRTGDLAR----------GAAAVSTDEMGDIIARYVAEGV 363 +E+ +E G T DLA ++T + D I + + Sbjct: 398 LEKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTTDFLDTIKSNLDRAL 449 >UniRef50_B6KL81 Isocitrate dehydrogenase, putative n=6 Tax=cellular organisms RepID=B6KL81_TOXGO Length = 594 Score = 203 bits (517), Expect = 7e-51, Method: Composition-based stats. Identities = 72/410 (17%), Positives = 124/410 (30%), Gaps = 65/410 (15%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCE 66 + + GD E+ ++ + I +YD+ D + + Sbjct: 188 VVEMDGD----EMARVIWAMIKEKLILPYLDIPLMYYDLSIQHRDKTDDQVTIDAALAIK 243 Query: 67 QADAVLFGSVGGPKWEHLPPDQ--QPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 + + + P + + + + +R P L + + P Sbjct: 244 RHGVGVKCATITPDEQRVKEFNLKKMWKSPNATIRNTLDGTIFRAPI-LMKNVPRLVPSW 302 Query: 125 ADIAANGFDILCVRELTGGIYFGQPKGREGSG------------QYEK---------AFD 163 I+ R Y + G E Sbjct: 303 TKP------IIIGRHAHADQYKALDFTVDKPGRFVMSFIPADKSNPEVHEVYEFKGGGVA 356 Query: 164 TEVY-HRFEIERIARIAFESARKRRHKVTSIDKANVL-QSSILWREIVNEI-ATEYP--- 217 +Y I+ A F+ A ++ + K VL + +++I I EY Sbjct: 357 LGMYNTDASIKGFAHSCFQYALDQKMPLYLSTKNTVLKKYDGRFKDIFQTIYEKEYKQKF 416 Query: 218 ---DVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNE 274 + H ID+ Q IK F V C N GD+ SD A GS+G++ S + Sbjct: 417 EEAGLWYEHRLIDDMVAQAIKSSGGF-VWACKNYDGDVQSDVVAQGYGSLGLMTSVLVCP 475 Query: 275 QGFGLY-EPAGGSAPDIAGKNI------ANPIAQILSLALLLRYSLDAD------DAACA 321 G + E A G+ + NPIA I + L + D + A Sbjct: 476 DGKTIEAEAAHGTVTRHYRQYQKGIKTSTNPIASIYAWTRSLGHRAKLDNNQKLKEFVEA 535 Query: 322 IERAINRALEEGIRTGDLA--------RGAAAVSTDEMGDIIARYVAEGV 363 +E A +E G T DLA + T++ D +AR + Sbjct: 536 LEDACVETVEAGFMTKDLALAIKGDKLTDRDYLCTEDFMDKLARVAERKL 585 >UniRef50_Q0CXI1 Isocitrate dehydrogenase, mitochondrial n=2 Tax=Eurotiomycetidae RepID=Q0CXI1_ASPTN Length = 466 Score = 202 bits (513), Expect = 2e-50, Method: Composition-based stats. Identities = 72/374 (19%), Positives = 117/374 (31%), Gaps = 60/374 (16%) Query: 42 HYDVGGAAIDNHGQPLPPATVEGCEQADAVLFGSVGGPKWEHLPPDQ--QPERGALLPLR 99 H G D + E ++ + + P + + + +R Sbjct: 97 HRPQGIEYRDQTDDKVTVEAAEAIKKYGVGVKCATITPDEARVEEFKLKKMWLSPNGTIR 156 Query: 100 KHFKLFSNLRPAKLYQGLEAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYE 159 P + + P I+ R G Y + G G+ E Sbjct: 157 NILGGTVFREPI-VIPAIPRLVPGWTKP------IIIGRHAFGDQYRATDRVIPGPGKLE 209 Query: 160 KAF--------DTEVY--------------HRFEIERIARIAFESARKRRHKVTSIDKAN 197 + +VY I A +F+ A + + K Sbjct: 210 LVYTPANGQPESVQVYDFQSGGGVAMSMYNTDDSIRGFAHSSFKMALLKGLPLYMSTKNT 269 Query: 198 VLQ-SSILWREIVNEI-ATEYP------DVELAHMYIDNATMQLIKDPSQFDVLLCSNLF 249 +L+ +++I EI EY + H ID+ Q+IK F ++ N Sbjct: 270 ILKRYDGRFKDIFQEIYEAEYKKEFDAKGIWYEHRLIDDMVAQMIKSEGGF-IMALKNYD 328 Query: 250 GDILSDECAMITGSMGMLPSASLNEQGFGLY-EPAGGSAPDIAGKNI------ANPIAQI 302 GD+ SD A GS+G++ S G E A G+ ++ NPIA I Sbjct: 329 GDVQSDIVAQGFGSLGLMTSTLTTPDGSAFESEAAHGTVTRHYREHQKGRETSTNPIASI 388 Query: 303 LSLALLLRYSLDADD------AACAIERAINRAL-EEGIRTGDLARGAAA------VSTD 349 + L D+ A +ERA + EEGI T DLA V+T Sbjct: 389 FAWTRGLVQRGQLDNTPDVVTFAEELERACIEVVNEEGIMTKDLALSCGRKEREAWVTTR 448 Query: 350 EMGDIIARYVAEGV 363 E + R + + Sbjct: 449 EYMAAVERRLKANL 462 >UniRef50_Q0V3G8 Putative uncharacterized protein n=1 Tax=Phaeosphaeria nodorum RepID=Q0V3G8_PHANO Length = 376 Score = 199 bits (506), Expect = 1e-49, Method: Composition-based stats. Identities = 73/386 (18%), Positives = 132/386 (34%), Gaps = 58/386 (15%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCE 66 + L GD E+ +V+ + I +YD+G D + E + Sbjct: 16 VVELDGD----EMTRIIWQVIKDKFIHPYLDIDLKYYDLGLEYRDETNDQVTLDAAEAIK 71 Query: 67 QADAVLFGSVGGPKWEHLPPD--QQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 + + + P + + ++ +R H P + + P Sbjct: 72 KYSVGVKCATITPDEQRVEEFKLKKMWLSPNGTIRNHLGGTVFRAPI-VIPAIPRLVPSW 130 Query: 125 ADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESAR 184 I+ R G Y + + + G E F + + E+ ++ E Sbjct: 131 KQP------IIIGRHAFGDQYRAKDRVIDTEGTLEMVFTPK-GGKPEVIKVYDFPAE--- 180 Query: 185 KRRHKVTSIDKANVLQSSILWREIVNEIAT-------EYPDVELAHMYIDNATMQLIKDP 237 V Q+ +++I EI E + H ID+ Q+IK Sbjct: 181 -----------GGVAQTQ--FKDIFQEIYEAQYRKEFEAAGIWYEHRLIDDMVAQMIKSE 227 Query: 238 SQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLY-EPAGGSAPDIAGKNI- 295 + ++ N GD+ SD A GS+G++ S + G E A G+ ++ Sbjct: 228 GGY-IIAMKNYDGDVQSDIVAQGFGSLGLMTSVLITPDGKTFEAEAAHGTVTRHYREHQK 286 Query: 296 -----ANPIAQILSLALLLRYSLDADD------AACAIERA-INRALEEGIRTGDLARGA 343 NPIA I + L + D+ A +E+A ++ E+GI T DLA Sbjct: 287 GRETSTNPIASIYAWTQGLIKRGELDNTPELVVFAEQLEKACVDTVNEDGIMTKDLALAQ 346 Query: 344 AA------VSTDEMGDIIARYVAEGV 363 V+T+E D + R + + Sbjct: 347 GKKDRSAWVTTNEYLDAVERRLKASL 372 >UniRef50_Q9LQK9 Putative isocitrate dehydrogenase [NAD] subunit-like 4 n=1 Tax=Arabidopsis thaliana RepID=IDH4_ARATH Length = 294 Score = 196 bits (498), Expect = 1e-48, Method: Composition-based stats. Identities = 73/363 (20%), Positives = 126/363 (34%), Gaps = 74/363 (20%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPA 60 M + + I V +V+DA++ + L Sbjct: 1 MPRPVTV-------IDSNVTNAVHQVMDAMQAPVYFETYIIKG--------KNMNHLTWE 45 Query: 61 TVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAF 120 V+ + L G V RK LF++L G + Sbjct: 46 VVDSIRKNKVCLNGRVN--------------NSLCGGARKELDLFASLVDCFNLNGQPS- 90 Query: 121 CPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAF 180 DI+ +RE T G Y G+ + G E T +F +RIA+ AF Sbjct: 91 -------RHENVDIVVIRENTEGEYAGR-EHEVVPGVIESFQVT--MTKFWSDRIAKYAF 140 Query: 181 ESA-RKRRHKVTSID---KANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKD 236 E A +R KVT++ K L + + E E+A YP++ I + + I+ Sbjct: 141 EYAHFSKRKKVTAVHNNGKYEKL-ADAFFLESCQEVAKMYPNITYNE--IASRETRAIRR 197 Query: 237 PSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIA 296 S S I+++ + + G S + + ++E G N Sbjct: 198 HSN------SKSLWAIIANIASGVAGG-------SFGDD-YAIFEQVGSVG------NHK 237 Query: 297 NPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIA 356 NP+A + S ++LR+ L A ++ A+ R + EG G + +T E+ D + Sbjct: 238 NPVALLFSSVMMLRHLL-LPLFADRLKTAVTRVISEGKC------GNSNTTTQEVVDSVI 290 Query: 357 RYV 359 + Sbjct: 291 ANL 293 >UniRef50_B4PZH5 GE17383 n=3 Tax=Drosophila RepID=B4PZH5_DROYA Length = 268 Score = 192 bits (489), Expect = 1e-47, Method: Composition-based stats. Identities = 57/160 (35%), Positives = 95/160 (59%), Gaps = 6/160 (3%) Query: 201 SSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMI 260 S L+ V ++A ++P+++ Y+D + ++++P ++DVL+ NL+GDILSD CA + Sbjct: 114 SDGLFLRCVRDMAQKFPEIQFEEKYLDTVCLNMVQNPGKYDVLVMPNLYGDILSDMCAGL 173 Query: 261 TGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAAC 320 G +G+ PS ++ G L+E G+APDIAGK++ANP A +LS ++LR+ ++ + A Sbjct: 174 VGGLGLTPSGNMGLNG-ALFESVHGTAPDIAGKDLANPTALLLSAVMMLRH-MELNTYAD 231 Query: 321 AIERAINRALEEG-IRTGDLARGAAAVSTDEMGDIIARYV 359 IERA ++EG TGDL E + I + Sbjct: 232 KIERAAFETIKEGKYLTGDL---GGRAKCSEFTNEICAKL 268 Score = 56.1 bits (134), Expect = 2e-06, Method: Composition-based stats. Identities = 13/54 (24%), Positives = 22/54 (40%), Gaps = 1/54 (1%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMR-ITTSHYDVGGAAIDNHG 54 S + ++PGDGIGPE+ K+ A + + + + HG Sbjct: 45 SGTKKVTLIPGDGIGPEISAAVQKIFTAANVPIEWEAVDVTPVRLSAIGFEAHG 98 >UniRef50_D0WIJ5 Isocitrate dehydrogenase, NADP-dependent n=2 Tax=Bacteria RepID=D0WIJ5_9ACTN Length = 434 Score = 187 bits (474), Expect = 7e-46, Method: Composition-based stats. Identities = 79/414 (19%), Positives = 140/414 (33%), Gaps = 63/414 (15%) Query: 1 MSK---NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPL 57 M+K + + GD E+ +++ + + T +YD+G A D + Sbjct: 33 MTKIQMTTPLVEMDGD----EMTRIMWQMIKDELICPFVDLKTEYYDLGLAHRDETDDQV 88 Query: 58 PPATVEGCEQADAVLFGSVGGPKWEHLPPDQ--QPERGALLPLRKHFKLFSNLRPAKLYQ 115 + E ++ + + P + + + +R P Sbjct: 89 TVDSAEATKRLGVAVKCATITPNAARVEEYDLKRMWKSPNGTIRAMLDGTVFRAPIV--- 145 Query: 116 GLEAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFD----------TE 165 + P + I R G +Y G G E + Sbjct: 146 -VRGIDPCVKNWVRP---ITLARHAYGDVYRDAEMRIPGPGTVELVYTASDGTETRRLVH 201 Query: 166 VYHRFE-----------IERIARIAFESARKRRHKVTSIDKANVLQS-SILWREIVNEI- 212 + IE AR F+ A V K + ++ +++I EI Sbjct: 202 EFTEPGVVEGMHNLDASIESFARACFDFALATSQDVWFATKDTISKTYDHRFKDIFQEIF 261 Query: 213 ----ATEYP--DVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGM 266 A + +E + ID+A +++K F + C N GD++SD + GS+ M Sbjct: 262 DADYAARFEAAGIEYFYTLIDDAVARVMKAEGGF-IWACKNYDGDVMSDMVSSAFGSLAM 320 Query: 267 LPSASLNEQGFGLYEPAGGSAPDIAGKNIA------NPIAQILSLALLLRYSLDAD---- 316 + S + G+ YE A G+ K++A N +A I + LR + D Sbjct: 321 MTSVLASPHGYWEYEAAHGTVQRHYYKHLAGEETSTNSVATIFAWTGALRKRAELDGLAD 380 Query: 317 --DAACAIERAINRALEEGIRTGDLARGA-----AAVSTDEMGDIIARYVAEGV 363 A A+E+A +E G TGDLAR +ST +A + + Sbjct: 381 LAAFADALEQATVATIESGKMTGDLARITSIEHPTKLSTGAFIKAVAEDLKGRL 434 >UniRef50_B9SFA3 NADP-specific isocitrate dehydrogenase, putative n=1 Tax=Ricinus communis RepID=B9SFA3_RICCO Length = 470 Score = 182 bits (462), Expect = 2e-44, Method: Composition-based stats. Identities = 62/405 (15%), Positives = 122/405 (30%), Gaps = 75/405 (18%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCE 66 I + GD E+ +++ + + ++D+G D + + E Sbjct: 87 IVEMDGD----EMTRVIWRMIKDKLIFPYLDLDIKYFDLGILNRDATDDKVTVESAEATL 142 Query: 67 QADAVLFGSVGGPKWEHLPPDQQP--ERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 + + + + P + R +R P + P Sbjct: 143 KYNVAVKCATITPDETRVKEFGLKSMWRSPNGTIRNILNGTVFREPILCL-NIPRIVPGW 201 Query: 125 ADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAF---------DTEVYHRFE---- 171 I R G Y +G G+ + F + +VY Sbjct: 202 KKP------ICIGRHAFGDQYRATDTLIKGPGKLKMIFVPEDGNTPLELDVYDFKGPGVA 255 Query: 172 ---------IERIARIAFESARKRRHKVTSIDKANVL-QSSILWREIVNEIATE-----Y 216 I A + A ++ + K +L + +++I E+ E + Sbjct: 256 LAMYNVDQSIRAFAESSMSLAFAKKWPLYLSTKNTILKKYDGRFKDIFQEVYEEKWKQKF 315 Query: 217 PD--VELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLN- 273 + + H ID+ +K + V C N GD+ SD + A+ Sbjct: 316 EEHSIWYEHRLIDDMVAYAVKSEGGY-VWACKNYDGDLSSD-------GKTLEAEAAHGT 367 Query: 274 -EQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDAD------DAACAIERAI 326 + F L++ ++ N IA I + L + D D +E + Sbjct: 368 VTRHFRLFQKGQETST--------NSIASIFAWTRGLEHRAKLDKNEGLLDFVHKLEGSC 419 Query: 327 NRALEEGIRTGDLA--------RGAAAVSTDEMGDIIARYVAEGV 363 +E G T DLA ++T+E D +A+ + + Sbjct: 420 IETVEAGKMTKDLAILIHGPKVSREFYLNTEEFIDAVAQNLESKL 464 >UniRef50_C5FHL7 Isocitrate dehydrogenase family protein n=1 Tax=Microsporum canis CBS 113480 RepID=C5FHL7_NANOT Length = 579 Score = 175 bits (443), Expect = 3e-42, Method: Composition-based stats. Identities = 66/377 (17%), Positives = 113/377 (29%), Gaps = 42/377 (11%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATV 62 I V G G GPE+ T V+ + +R+++ + D + ++ PL + Sbjct: 5 DPLRIGVAIGHGTGPELATVFEHVVRELASRYSLGVEFVRSDRIYHSYNS--LPLADESQ 62 Query: 63 EGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCP 122 P + L R A Q L A Sbjct: 63 NA-------------TPDICDETVNDITHYQQFCEQEASRGLKVIFRTAISAQSLYAVRQ 109 Query: 123 LRADIAANGFD-----ILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIAR 177 + FD +L +R+ G Y G K + + + I Sbjct: 110 QLEAVKVECFDRGTSSLLVIRDQAQGFYTGTNKLESDQDSVSRVCHFR---KGVFQHIIA 166 Query: 178 IAFESARK-------RRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNAT 230 + E AR+ V + K ++ L + E+ +++ + D Sbjct: 167 FSLERAREKWGYDLGGIKSVFLVYKFHLF--DGLLLSWARDWTKEF-GIKVEFIQPDTMN 223 Query: 231 MQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNE------QGFGLYEPAG 284 LI +++ N + DI+ S S N Y+ Sbjct: 224 RNLIAFGVHRCLMIAGNEYADIMQTIFLEKFNMRVQETSCSENVYLKPVLNRLSEYQTTH 283 Query: 285 GSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAA 344 GSA DI GK I NP A I + A +L ++ +N + T D Sbjct: 284 GSADDITGKGIVNPSATIRAAAAILERFGGCVGIDAKVDDTLNILQKNKSGTPD---QGG 340 Query: 345 AVSTDEMGDIIARYVAE 361 ++T D+ R + Sbjct: 341 NLTTAAFVDVFLRTLPS 357 >UniRef50_UPI0001C163C2 Isocitrate dehydrogenase NADP-dependent, prokaryotic n=3 Tax=Nostocaceae RepID=UPI0001C163C2 Length = 474 Score = 174 bits (442), Expect = 3e-42, Method: Composition-based stats. Identities = 51/247 (20%), Positives = 94/247 (38%), Gaps = 45/247 (18%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFA---MRITTSHYDVGGAAIDNHGQP-- 56 N + + GDG G ++ KVLDA + +I+ G A D +G Sbjct: 24 PDNPIVPFIRGDGTGIDIWPATEKVLDAAVAKAYNGKRKISWFKVYAGDEACDLYGTYQY 83 Query: 57 LPPATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQG 116 LP T+ ++ + G + P + R + LR+ F L++ +RP + Y G Sbjct: 84 LPQDTLTAIKEYGIAIKGPLTTPIGGGI-------RSLNVALRQIFDLYACVRPCRYYAG 136 Query: 117 LEAFCPLRADIAANGFDILCVRELTGGIYFGQ------------------------PKGR 152 + + + D++ RE T IY G P+ Sbjct: 137 TPSP-----HKSPDKLDVIVYRENTEDIYLGIEWKQGSEIGERLINILNKDLIPATPEHG 191 Query: 153 EGSGQYEKAFDTEVYHRFEIERIARIAFESAR---KRRHKVTSIDKANVLQ-SSILWREI 208 + + + R +R+ R A + A K + +VT + K N+++ + +R+ Sbjct: 192 KKQIPLDAGIGIKPISRSGSQRLVRRALKHALQLPKEKQQVTLVHKGNIMKYTEGAFRDW 251 Query: 209 VNEIATE 215 E+AT+ Sbjct: 252 GYELATQ 258 Score = 150 bits (379), Expect = 8e-35, Method: Composition-based stats. Identities = 46/163 (28%), Positives = 74/163 (45%), Gaps = 16/163 (9%) Query: 200 QSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAM 259 W++ V + D+ Q+ P ++ +L NL GD LSD A Sbjct: 321 HGDGQWKD----------KVMVNDRIADSIFQQIQTRPDEYSILATMNLNGDYLSDAAAA 370 Query: 260 ITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAA 319 I G +GM P A++ + ++E G+AP AG + NP + ILS ++L Y + +AA Sbjct: 371 IVGGLGMGPGANIGDSC-AIFEATHGTAPKHAGLDKINPGSVILSGVMMLEY-MGWQEAA 428 Query: 320 CAIERAINRALEEGIRTGDLAR----GAAAVSTDEMGDIIARY 358 I+R + ++ +G T DLAR + E D I + Sbjct: 429 DLIKRGLGASIADGKVTYDLARLMEPPVEPLKCSEFADTIIQQ 471 >UniRef50_A1D5P0 Isocitrate dehydrogenase family protein n=4 Tax=Trichocomaceae RepID=A1D5P0_NEOFI Length = 558 Score = 169 bits (429), Expect = 1e-40, Method: Composition-based stats. Identities = 67/379 (17%), Positives = 122/379 (32%), Gaps = 45/379 (11%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAID-----NHGQ 55 MS + + + G+G GPE+ +V+ ++ R+ + +T + N Sbjct: 1 MS-SIQVGLAVGNGTGPELTAIFERVIQSLAARYNVSVTFLRSPRIYNSYSSLLAINDAD 59 Query: 56 PLPPATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQ 115 + T+ +V AL +R+ Sbjct: 60 AVTEETLSDAAHYRQFCKEAVSCGVRAIFRTSISA--QALYLVREQL------------- 104 Query: 116 GLEAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERI 175 + + IL VR+ G Y G + + T + + RI Sbjct: 105 ---QAIKVEHFTLSPTSSILLVRDQAQGFYSGTN---SVNTSKDAVSRTAHFSKAIFARI 158 Query: 176 ARIAFESARK---RRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQ 232 A A + + VT + K ++ L+ E + V + + D Sbjct: 159 LSYALGRANQLWGGTNSVTMVYKFHLF--DGLFHTWATEWERTF-GVNIRFVQGDTMNRD 215 Query: 233 LIK-DPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNE-------QGFGLYEPAG 284 L+ S ++L+ N + DI+ G +G SA QG Y+ A Sbjct: 216 LLAFGVSGHNLLISGNEYADIMQTILLDRFG-LGAQESACAENVYLHPDVQGLSEYQTAH 274 Query: 285 GSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAA 344 GSA D+ GK I NP A I + A +L ++ + GI T D Sbjct: 275 GSADDLLGKGIVNPTATIRAAAAVLEDQAGCSGLKQRVDCVLGDLGARGIGTPD---QGG 331 Query: 345 AVSTDEMGDIIARYVAEGV 363 +T+ + + + + + Sbjct: 332 TATTERFVEAFLQGLDQPL 350 >UniRef50_P80046 Isocitrate dehydrogenase [NADP] n=54 Tax=cellular organisms RepID=IDH_SYNY3 Length = 475 Score = 168 bits (426), Expect = 2e-40, Method: Composition-based stats. Identities = 45/245 (18%), Positives = 83/245 (33%), Gaps = 45/245 (18%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRF---AMRITTSHYDVGGAAIDNHGQP-- 56 + I + GDG G ++ V++A + I G A + +G Sbjct: 24 PNDPIIPYIRGDGTGVDIWPATELVINAAIAKAYGGREEINWFKVYAGDEACELYGTYQI 83 Query: 57 LPPATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQG 116 P T+ ++ + G + P + R + LR+ F L++ +RP + Y G Sbjct: 84 FPEDTLTAIKEYGVAIKGPLTTPVGGGI-------RSLNVALRQIFDLYTCVRPCRYYPG 136 Query: 117 LEAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQ------------------- 157 + DI+ RE T IY G G Sbjct: 137 TPSP-----HKTPEKLDIIVYRENTEDIYLGIEWAEGTEGAKKLIAYLNDELIPTTPALG 191 Query: 158 -----YEKAFDTEVYHRFEIERIARIAFESAR---KRRHKVTSIDKANVLQ-SSILWREI 208 + + + +R+ R A A+ K + VT + K N+++ + +R+ Sbjct: 192 KKQIRLDSGIGIKPISKTGSQRLVRRAILHAKRLPKAKQMVTLVHKGNIMKFTEGPFRDW 251 Query: 209 VNEIA 213 E+A Sbjct: 252 GYELA 256 Score = 143 bits (360), Expect = 1e-32, Method: Composition-based stats. Identities = 42/147 (28%), Positives = 68/147 (46%), Gaps = 7/147 (4%) Query: 217 PDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQG 276 V + D+ Q+ P ++ +L NL GD LSD A + G +GM P A++ + Sbjct: 328 EKVMVNDRIADSIFQQIQTRPDEYSILATMNLNGDYLSDAAAAVVGGLGMGPGANIGDS- 386 Query: 277 FGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRT 336 ++E G+AP AG + NP + ILS ++L + + +AA I++ I A+ T Sbjct: 387 AAIFEATHGTAPKHAGLDRINPGSVILSGVMMLEF-MGWQEAADLIKKGIGAAIANREVT 445 Query: 337 GDLAR-----GAAAVSTDEMGDIIARY 358 DLAR + E I + Sbjct: 446 YDLARLMEPKVDKPLKCSEFAQAIVSH 472 >UniRef50_A8E541 Idh3a protein n=4 Tax=Euteleostomi RepID=A8E541_DANRE Length = 157 Score = 167 bits (424), Expect = 4e-40, Method: Composition-based stats. Identities = 51/133 (38%), Positives = 75/133 (56%), Gaps = 5/133 (3%) Query: 229 ATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAP 288 + +++DPSQFDVL+ NL+GDILSD CA + G +G+ PS ++ G ++E G+AP Sbjct: 26 FSRGMVQDPSQFDVLVMPNLYGDILSDLCAGLIGGLGVTPSGNIGANGVAIFESVHGTAP 85 Query: 289 DIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEE-GIRTGDLARGAAAVS 347 DIAGK++ANP A +LS ++LR+ + A IE A + + + T DL Sbjct: 86 DIAGKDMANPTALLLSAVMMLRH-MGLHGHAKKIETACFDTIRDKKVLTKDL---GGNPK 141 Query: 348 TDEMGDIIARYVA 360 E I R V Sbjct: 142 CSEFTADICRRVQ 154 >UniRef50_A5B8K4 Putative uncharacterized protein n=2 Tax=Magnoliophyta RepID=A5B8K4_VITVI Length = 486 Score = 165 bits (418), Expect = 2e-39, Method: Composition-based stats. Identities = 68/437 (15%), Positives = 114/437 (26%), Gaps = 108/437 (24%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCE 66 I + GD E+ +++ + + ++D+G D + + E Sbjct: 67 IVEMDGD----EMARIMWRMIKDKLIFPYLDLDIRYFDLGILNRDATDDKVTVESAEATL 122 Query: 67 QADAVLFGSVGGPKWEHLPPDQQP--ERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 + + + + P + R +R P L + P Sbjct: 123 KYNVAVKCATITPDEARVKEFGLKSMWRSPNGTIRNILNGTVFREPI-LCXNVPRIVPGW 181 Query: 125 ADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKA---------FDTEVYHRFE---- 171 I R G Y EG G+ + + VY Sbjct: 182 KKP------ICIGRHAFGDQYRATDTVVEGPGKLKLVFAPENGDPPVELNVYDFKGPGIA 235 Query: 172 ---------IERIARIAFESARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELA 222 I A + A ++ + K +L+ +Y Sbjct: 236 LAMYNVDESIRAFAESSMSLAFAKKWPLYLSTKNTILK--------------KYDG-RYE 280 Query: 223 HMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAM----------------------- 259 H ID+ +K + V C N GD+ SD A Sbjct: 281 HRLIDDMVAYALKSDGGY-VWACKNYDGDVQSDLLAQGFLLHMRNERSDYPVXLHLVKSY 339 Query: 260 ----------ITGSMGM---LPSASLNEQGFGLY-EPAGGSAPDIAGKNI------ANPI 299 GS + L+ G L E A G+ + N I Sbjct: 340 PILFVLSRIRFFGSYDFSIAISGKQLSSDGKTLEAEAAHGTVTRHFRQYQKGLETSTNSI 399 Query: 300 AQILSLALLLRYSLDAD------DAACAIERAINRALEEGIRTGDL--------ARGAAA 345 A I + L + D D +E A +E G T DL A Sbjct: 400 ASIFAWTRGLEHRAKLDKNERLLDFVHKLEAACIETVESGNMTKDLAILIHGPKASXEFY 459 Query: 346 VSTDEMGDIIARYVAEG 362 ++T+E D +A + Sbjct: 460 LNTEEFIDTVAHNLEAK 476 >UniRef50_A2Q9Q7 Contig An01c0300, complete genome n=6 Tax=Trichocomaceae RepID=A2Q9Q7_ASPNC Length = 565 Score = 164 bits (416), Expect = 4e-39, Method: Composition-based stats. Identities = 58/380 (15%), Positives = 124/380 (32%), Gaps = 49/380 (12%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAI---------DNH 53 + + + G G G E++ +V+ + ++++ + N Sbjct: 4 QTVRLGLAVGHGTGRELVAVFERVIQTLAKQYSVNFEFVRSSSTYHSYHTLTVSGEDKNL 63 Query: 54 GQPLPPATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKL 113 + T + + G +L +R+H + + + L Sbjct: 64 ITHIADETTKDAIDYQQFCENAAGSGIAAIFRTAI--HAQSLYLVRQHLQA-AKVEHFSL 120 Query: 114 YQGLEAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIE 173 G +L VR+ G Y G T + + + Sbjct: 121 GDGNA---------------LLMVRDEAQGFYAGDNTYSADQLSI---TRTTSFSKPVFD 162 Query: 174 RIARIAFESARKR------RHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYID 227 RI R A + A + KVT K ++ +++ + ++ ++ + D Sbjct: 163 RIIRFALDRAAENWGPENVPKKVTMAYKFHLF--DGVFQAWEPQWKAQF-GIDFDFIQPD 219 Query: 228 NATMQLIKD-PSQFDVLLCSNLFGDILSDECAMITG--SMGMLPSASL----NEQGFGLY 280 L+ + +++ N + D++ G + + + ++ + G Y Sbjct: 220 TLNRSLMANGVQGRCIIIAGNEYADVIQPVFLNWFGQSTPETMYAENVYLRPDVNGLSEY 279 Query: 281 EPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLA 340 + GSA IA K + NP A I + A +L E+AI L+ + T D Sbjct: 280 QTVHGSADAIADKGLVNPFATIRAAAAILERHAGGKGIQKLTEQAIQSLLQRKLTTPD-- 337 Query: 341 RGAAAVSTDEMGDIIARYVA 360 ++ T+E D + +A Sbjct: 338 -QGGSLKTEETVDHFLQAIA 356 >UniRef50_A4SBK5 Predicted protein n=6 Tax=Eukaryota RepID=A4SBK5_OSTLU Length = 409 Score = 161 bits (408), Expect = 3e-38, Method: Composition-based stats. Identities = 65/402 (16%), Positives = 130/402 (32%), Gaps = 68/402 (16%) Query: 16 GPEVMTQALKVLDAVRNRFAMRIT-TSHYDVGGAAIDNHGQPLPPATVEGCEQADAVLFG 74 G E+ + ++ A + T +D+ D+ + +E + A+ Sbjct: 18 GEEMTAYVMDLIRAKWIEPRVDTTAWREFDLRAKNRDDTEDQVLRDVIEAGKAVKAIFKE 77 Query: 75 SVGGPKWEHLPPDQ--QPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRADIAANGF 132 P + + + +R+ + + R G+E + + Sbjct: 78 PTVTPTADQVKRLGLRKSWGSPNGAMRRGWNGITISRDTIHIDGVELGY--KKPVFFE-- 133 Query: 133 DILCVRELTGGIYF------GQPKGREGSGQYE-------KAFDTEVYHRFE-------- 171 R GG Y G+ E D+ E Sbjct: 134 -----RHAVGGEYAAGYKNVGKGTLVTTFTPSEGPDAGKPVEVDSRTITDNEAAVVTYHN 188 Query: 172 ----IERIARIAFESARKRRHKVTSIDKANVLQSSILWREIVNEI-ATEYP--------- 217 + +AR F + + + K V + + +I+ ++ EY Sbjct: 189 PYDNVHELARFFFGRCLEAKITPYVVTKKTVFKWQEPFWQIMKKVFDEEYKSKFVDAGVM 248 Query: 218 --DVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQ 275 EL H+ D ATM+L++ + N GD+L+DE A I S G + S + Sbjct: 249 KSGDELVHLLSDAATMKLVQWRQGGFGMAAHNYDGDVLTDELAQIHKSPGFITSNLVGVD 308 Query: 276 GFGL----YEPAGGSAPDI------AGKNIANPIAQILSLALLLRYSLDAD--------D 317 G +E + G+ D+ + NP+ + L + ++ D Sbjct: 309 ENGTLIKEFEASHGTVADMDEARLRGEETSLNPLGMVEGLIGAMNHAADVHNVDKERTLA 368 Query: 318 AACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYV 359 + I++ EG T DL+ + ++T++ D +A + Sbjct: 369 FTAKMRAVIHQLFREGKGTRDLSGPSG-LTTEQFVDAVAERL 409 >UniRef50_B5DZV4 GA24694 n=6 Tax=Drosophila RepID=B5DZV4_DROPS Length = 395 Score = 159 bits (402), Expect = 2e-37, Method: Composition-based stats. Identities = 56/273 (20%), Positives = 111/273 (40%), Gaps = 20/273 (7%) Query: 96 LPLRKHFKLFSNLRPAKLYQGLEAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGS 155 L + L+ + + + G + P DI + + G Y + + Sbjct: 135 LKICNDLDLYVFMTRLRSFPGFKCRFP--------DVDIQVIAQNNIGNYS-ELEYAPVK 185 Query: 156 GQYEKAFDTEVYHRFEIERIARIAFESA-RKRRHKVTSIDKANV-LQSSILWREIVNEIA 213 G E V + + R AFE+A R R +VT I KAN + EI ++ Sbjct: 186 GVVEA---LRVVTHENVTKYLRHAFEAAIRAGRCRVTLIHKANEWPVTDGAMVEIAEKMH 242 Query: 214 TE-YPDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASL 272 E Y ++L M +D+ +LI DP+ FD + ++ + L+ C+ + G + + L Sbjct: 243 AEDYCSIKLELMELDDCVNRLITDPAYFDTIFTNDRYATFLATICSGVAGGANLFSAIEL 302 Query: 273 NEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEE 332 + +++P + + ++ +P I+S + L + + A ++ + + R + + Sbjct: 303 GDS-HAVFKPLQ-TKLSLTNYSLLSPYG-IVSTCVDLLNHVGQESCAKSLWKGMLRTMTD 359 Query: 333 GIRTG--DLARGAAAVSTDEMGDIIARYVAEGV 363 GI+T D V + M + + E V Sbjct: 360 GIKTVEFDGPDTGEYVICNIMNKLRCSALGENV 392 >UniRef50_B3MF82 GF11274 n=1 Tax=Drosophila ananassae RepID=B3MF82_DROAN Length = 382 Score = 156 bits (395), Expect = 1e-36, Method: Composition-based stats. Identities = 49/270 (18%), Positives = 99/270 (36%), Gaps = 25/270 (9%) Query: 96 LPLRKHFKLFSNLRPAKLYQGLEAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGS 155 + L L+ + + G P +I + + G+Y + Sbjct: 126 MKLCNDLDLYMFKCRVRSFPGFNCRFP--------DVNIRIIAQNNMGVYSDL-EYSPVK 176 Query: 156 GQYEKAFDTEVYHRFEIERIARIAFESA-RKRRHKVTSIDKANV-LQSSILWREIVNEIA 213 G E V + E+ R AF +A + R +VT I K+ + EI Sbjct: 177 GVVEA---ISVSTQEGNEKYLRKAFATAVKANRKRVTLIHKSTEWPITDGAMVSAAKEIH 233 Query: 214 TEYPD-VELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASL 272 +Y +EL M +++ +LI P +FD + S+ + +++ C+ I G + + + Sbjct: 234 KDYEHCLELELMNVEDCIGRLITHPQEFDCIFSSDRYATMIATMCSGICGGANLFSAVEI 293 Query: 273 NEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEE 332 + +++P + I +P + ++ L + L + A+ + R +E Sbjct: 294 GDF-HAVFKPLQ-VKLSLTNYPILSPYGIVNTIVDLFDH-LGYTECGDALWEQMLRTMES 350 Query: 333 GIRTGDLAR--GAAAVSTDEMGDIIARYVA 360 GI+T D V + I + Sbjct: 351 GIKTKDFGGEDSGEYVICN-----IINRLR 375 >UniRef50_B8BX37 Predicted protein n=1 Tax=Thalassiosira pseudonana RepID=B8BX37_THAPS Length = 560 Score = 155 bits (392), Expect = 2e-36, Method: Composition-based stats. Identities = 70/412 (16%), Positives = 136/412 (33%), Gaps = 79/412 (19%) Query: 16 GPEVMTQALKVL--DAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCEQADAVLF 73 G E+ A ++L + F + + +D+ A D+ VE ++ A+ Sbjct: 89 GEEMTHYATQLLLNQWIEPYFDIS-SWETFDLSCKARDDSDDATLIDAVEAGKRIGAIFK 147 Query: 74 GSVGGPKWEHLPPD--QQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRADIAANG 131 P + ++ +R+ + + R +G+E + Sbjct: 148 EPTITPSAIQVQEMGLKKAWGSPNGAMRRGWNGITISRDTIHIEGIELGYKNQ------- 200 Query: 132 FDILCVRELTGGIY-FGQPKGREG---------SGQYEKAFDTEVYHRF----------- 170 +L R GG Y G + EG G D Sbjct: 201 --VLFERHAVGGEYGAGWNEVGEGTLLTTYIPKDGGAPFVVDKRDLTDKHNVCVVYHNPY 258 Query: 171 -EIERIARIAFESARKRRHKVTSIDKANVLQSSILWREIVNEIATE-YPD---------- 218 + +A + F+ + + + K V + + + + + Y D Sbjct: 259 DNVRELAHLFFKRCLEHKVTPYIVTKKTVFKWQEGFWATMKRVFDDTYKDEFLKAGLLDR 318 Query: 219 --VELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLN--E 274 EL H+ D ATMQLI+ + N GD+L+D+ A + S G + S + + Sbjct: 319 SGGELTHLISDAATMQLIRWTDGGFGMAAHNYDGDMLTDQIAQVHRSPGFITSNLVGVSD 378 Query: 275 QGFGL---YEPAGGSAPDIAGKNIA------NPIAQILS--LALL----LRYSLDADD-A 318 G L +E + G+ D+ ++A NP+ + + A+ L Y +D Sbjct: 379 DGTTLIKEFEASHGTVTDLWNDHLAGKETSLNPLGLVEALLGAMCHAAQLEYDAKPNDVE 438 Query: 319 ACAIER-----------AINRALEEGIRTGDLARGAAAVSTDEMGDIIARYV 359 A + A++ G T D+ +T++ +A + Sbjct: 439 AKRMYEYVNNFTNTLRMALHNTFRYGQGTRDMCGPTG-FTTEDFIAKVAWRL 489 >UniRef50_C7YNU4 Putative uncharacterized protein n=1 Tax=Nectria haematococca mpVI 77-13-4 RepID=C7YNU4_NECH7 Length = 307 Score = 154 bits (390), Expect = 4e-36, Method: Composition-based stats. Identities = 77/291 (26%), Positives = 128/291 (43%), Gaps = 33/291 (11%) Query: 80 KWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRADIAANGFDILCVRE 139 + P +PERG LL LRK + ++RP + P + + C R Sbjct: 33 VRDGAPATSRPERG-LLKLRKEMGTYGSMRPC-FFASDSLVAPQGRGVPRHRL-CHCARA 89 Query: 140 LTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARKRR-HKVTSIDKANV 198 + A++TE Y E+ER +A R R K+ S+D ANV Sbjct: 90 HRRYL------LWRAQTGSGSAWNTEPYSHAEVERFTHLAGFLTRGRGDKKLWSLDNANV 143 Query: 199 LQSSILWREIVNEI-ATEYPDVELAHMYIDNATMQLIKDPSQFD-VLLCSNLFGDILSDE 256 L +S WR+++ E E+PD+++ H I++A M ++K+P+ + V++ S LFGDI+SD Sbjct: 144 LATSRFWRKVMTETFEKEFPDLKVEHQLINSAVMIMVKNPTGLNGVVVTSTLFGDIISDA 203 Query: 257 CAMITGSMGMLPSASL------NEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLR 310 +I S+G+LPSASL N + +YEP + + A+ S Sbjct: 204 ARVIPDSIGLLPSASLSGIPDGNRKSNDIYEPIH--VLPLVSRARASSTPSARSC----- 256 Query: 311 YSLDADDAACAIERAINR--ALEEGIRTGDLARGAAAVSTDEMGDIIARYV 359 + + ++ R +RT +L +T E+G+ + V Sbjct: 257 ---PWPCFSDTLSTSLRRLWVPPWSLRTKEL---GGGANTKELGEAVINEV 301 >UniRef50_Q6L1Z1 Isocitrate dehydrogenase [NADP] n=1 Tax=Picrophilus torridus RepID=Q6L1Z1_PICTO Length = 355 Score = 154 bits (390), Expect = 4e-36, Method: Composition-based stats. Identities = 59/374 (15%), Positives = 137/374 (36%), Gaps = 45/374 (12%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRN---RFAMRITTSHYDVGGAAIDNHGQPL 57 + + I + GDG G E+ + +++ + I +G A + +G+ L Sbjct: 12 IPDDVTIGYIEGDGEGTELTRAMINAVNSAIEIAYSGSKSIEWKKIYIGREAYEKYGKYL 71 Query: 58 PPATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGL 117 P ++E + V+ G + + +++ L+++++ GL Sbjct: 72 PRESIEDIRKTVFVMKGPL---------SSNINGHDININIKRILNLYTDVKCITGLPGL 122 Query: 118 EA------FCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFE 171 F P ++ +D + + + S D++++ + Sbjct: 123 SEGKEIFIFSPSIDEVYHFSYD-------SEDS-DMLRQYLQQSFNISIGGDSDIFLKGT 174 Query: 172 IE-RIARIAFESA----RKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYI 226 RI +IA + A + D + + +N++ E P VE+ ++Y Sbjct: 175 SRYRIIKIASKIAEISSLYGIKRTLVADDYTGSHAPLWVYNTLNKM--EMP-VEIENLY- 230 Query: 227 DNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGS 286 + S+F++ + + ++ T A L + L+E Sbjct: 231 --NLYDEMTSESRFNIFIPDSRLSSLIIKIINART-----FFGAILGDF-ISLFESQSRP 282 Query: 287 APDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAAAV 346 + G ++A+P + +L+ +++LR L+ +DAA + A+N +GI L + Sbjct: 283 SFTEEGYDLADPTSFLLASSMMLR-RLNFNDAALILRNALNSVYSDGILPASLNLNNG-L 340 Query: 347 STDEMGDIIARYVA 360 + D I + + Sbjct: 341 KCSDFIDAIVKRMK 354 >UniRef50_UPI00017440F3 Isocitrate dehydrogenase (NAD(+)) n=1 Tax=candidate division TM7 single-cell isolate TM7a RepID=UPI00017440F3 Length = 175 Score = 146 bits (369), Expect = 1e-33, Method: Composition-based stats. Identities = 37/173 (21%), Positives = 71/173 (41%), Gaps = 21/173 (12%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 I ++PGDGIG E+ +K+ DA + + + + G + G+ +P + E Sbjct: 3 KITLIPGDGIGYEISESLVKIFDAAK----VPVEFETENAGSDVYEKTGELIPESLYESV 58 Query: 66 EQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRA 125 E+ + G + P + R + LRK + L++N R ++ G+ Sbjct: 59 ERNKIAIKGPITTPIGKGF-------RSINVYLRKKYDLYTNFRSSRNLPGI-------- 103 Query: 126 DIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARI 178 + + D+ RE T GIY G+ K + A + + E + ++ Sbjct: 104 ETRYDNIDLAIFRENTEGIYIGEEKYEN--EEKTSAIAVKRITKKGSEELLKV 154 >UniRef50_A7T3D9 Predicted protein n=2 Tax=cellular organisms RepID=A7T3D9_NEMVE Length = 419 Score = 146 bits (369), Expect = 1e-33, Method: Composition-based stats. Identities = 39/208 (18%), Positives = 69/208 (33%), Gaps = 36/208 (17%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRF---AMRITTSHYDVGGAAID--NHGQP 56 N I + GDGIG ++ +KV+DA + +I+ G A + Sbjct: 26 PNNPIIPFIEGDGIGIDISPVMIKVVDAAVQKAYGGERKISWMEVYAGEKATQVYDQDTW 85 Query: 57 LPPATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQG 116 LP T++ + + G + P + R + LR+ L+ LRP + ++G Sbjct: 86 LPQETLDAVKDYVVSIKGPLTTPVGGGI-------RSLNVALRQQLDLYVCLRPVRWFEG 138 Query: 117 LEAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSG-------------------Q 157 + + D+ RE + IY G Sbjct: 139 VPSPVK-----KPGDVDMTIFRENSEDIYAGIEWKAGSPEATKVIKFLKEEMGVTKIRFD 193 Query: 158 YEKAFDTEVYHRFEIERIARIAFESARK 185 + + + +R+AR A SA Sbjct: 194 QDCGIGVKPVSKEGTKRLARKALHSAEA 221 >UniRef50_Q03UU7 3-isopropylmalate dehydrogenase n=4 Tax=Leuconostoc mesenteroides RepID=Q03UU7_LEUMM Length = 308 Score = 142 bits (359), Expect = 2e-32, Method: Composition-based stats. Identities = 61/285 (21%), Positives = 115/285 (40%), Gaps = 9/285 (3%) Query: 5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEG 64 Y +A+L GD V+ +AL ++ + N + G + + +PLP T+ Sbjct: 2 YKLAILKGDKESSSVIDRALGIIKSSVNDSTA-FEVTELPFGVNGVLSFNEPLPNQTLRE 60 Query: 65 CEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 + D +L G++ + +L+ LRK+ + + ++ PL+ Sbjct: 61 LKNYDGILVGALNQEVGTD---SLLSVQESLVALRKYLNITLACKAVQISDNNVDASPLK 117 Query: 125 ADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESAR 184 I D + V+ + A DT Y + E+E++ FE A Sbjct: 118 NQIV-RDTDFIIVQSAK----RANDHVDGNISVDDFAQDTITYEQREVEQVITAGFERAM 172 Query: 185 KRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLL 244 R+ VT + + +S +W +IA YPDV + ++ + +I+ P+ DV++ Sbjct: 173 NRKRAVTVVTPFDSFYTSKIWALTAEKIAKIYPDVVVNYVSLSCVISTIIQQPTSLDVVV 232 Query: 245 CSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPD 289 +L++E ITG +P + N G LY+ + D Sbjct: 233 APKWVDQVLNEESQKITGLPETVPVSMKNNSGQMLYQLPQINVDD 277 >UniRef50_Q7XZ87 Isocitrate dehydrogenase (Fragment) n=1 Tax=Griffithsia japonica RepID=Q7XZ87_GRIJA Length = 187 Score = 138 bits (348), Expect = 3e-31, Method: Composition-based stats. Identities = 33/181 (18%), Positives = 61/181 (33%), Gaps = 23/181 (12%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPAT 61 S + + + PG G+GPE+ + +A + I + + + Sbjct: 29 SPQFTVTLFPGHGVGPEISVAVQNIFNAA----DVPIVWDEHHIDVDNAKPGQDLISADA 84 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFC 121 ++ + L G + P + R L LRK L++N+RP G++ Sbjct: 85 LDSLRRNRFGLKGPMATPIG-------KGYRSLNLTLRKALGLYANVRPCVSIPGVQTPY 137 Query: 122 PLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFE 181 + D++ VRE T G Y G E +V + ++ F Sbjct: 138 --------DDVDVVTVRENTEGEYSG----LEHVVYPGVVESLKVITPERVNARVQVPFS 185 Query: 182 S 182 Sbjct: 186 I 186 >UniRef50_B5G7Q5 Truncated isocitrate dehydrogenase family protein n=4 Tax=Streptomyces RepID=B5G7Q5_9ACTO Length = 411 Score = 132 bits (332), Expect = 2e-29, Method: Composition-based stats. Identities = 75/375 (20%), Positives = 121/375 (32%), Gaps = 48/375 (12%) Query: 5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEG 64 + + G G G EV +VL + R +T ++ P AT Sbjct: 31 PTVGLAVGRGTGEEVAAVFTRVLGHLATRHERPVTLVRSP---RVYHSYVSLRPLATEP- 86 Query: 65 CEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLR 124 G G P+ L + L R R A Q L Sbjct: 87 ---------GGAGVPEIRRLSAEDAAHYEEWLRARARAGTRVVFRTAINAQSLYLVRQRL 137 Query: 125 ADIAANGFD-----ILCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIA 179 + + D +L VR+ G Y G G T + R E++ A Sbjct: 138 RAVKVDTLDADGARLLLVRDEAQGFYTGGNTHTPGHVSR-----TTEFSREITEQLLAYA 192 Query: 180 FESARK----RRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIK 235 AR+ ++ K ++L V + A ++E+ D L+ Sbjct: 193 LRRAREEWPEGPARIVMAYKFHLL--DGALDAWVRDFAAR-ENIEVGVFQPDTVNRNLVA 249 Query: 236 DP-SQFDVLLCSNLFGDILSDECAMITGS----------MGMLPSASLNEQGFGLYEPAG 284 P VLL N + DI+ GS + + P+ + Y+ Sbjct: 250 HPPEDRTVLLAGNEWADIMHLVLLDRYGSGRQEDHCTRNVHLDPAVA----ELVEYQTVH 305 Query: 285 GSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLARGAA 344 GSA D+ G+++ NP+A + + A + + A A E A+ R G+RT D Sbjct: 306 GSADDLEGRDLLNPVATLRAAAAIAERYVGCTGAEAATEAALARLAAAGVRTPD---QGG 362 Query: 345 AVSTDEMGDIIARYV 359 ST + D + Sbjct: 363 KHSTTGVVDAFIEEL 377 >UniRef50_A5BNI3 Putative uncharacterized protein n=1 Tax=Vitis vinifera RepID=A5BNI3_VITVI Length = 175 Score = 123 bits (310), Expect = 9e-27, Method: Composition-based stats. Identities = 50/114 (43%), Positives = 66/114 (57%), Gaps = 1/114 (0%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPAT 61 K Y I +LPGDGIGPEV++ A VL + + VGG A+D G PLP T Sbjct: 40 PKRYSITLLPGDGIGPEVISVAKNVLKLAGSLEGIEFGFQEMPVGGCALDLTGVPLPEET 99 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQ 115 + +Q+DAVL G++GG KW+ +PE G LL LR K+F+NLRPA + Sbjct: 100 LLVAKQSDAVLLGAIGGYKWDSNEKHLKPETG-LLQLRSGLKVFANLRPASVLP 152 >UniRef50_A3JDN6 Isocitrate dehydrogenase n=5 Tax=Gammaproteobacteria RepID=A3JDN6_9ALTE Length = 582 Score = 116 bits (292), Expect = 9e-25, Method: Composition-based stats. Identities = 55/284 (19%), Positives = 95/284 (33%), Gaps = 49/284 (17%) Query: 124 RADIAANGFDILCVRELTGG--IYFGQPKGREGSGQYEKAFD----------------TE 165 R I + R GG Y + G + D Sbjct: 299 RYGIPVRNAHVSISRMSAGGGDQYGSFNMPAQEDGILKVVVDGVEKHARRVSQGDPILLM 358 Query: 166 VYHRFEIERIARIAFESARKRRHKVTSIDKANVLQSSILW----REIVNEIATEYPDVE- 220 I+ F A + +V K ++ ++ ++ E+A ++ Sbjct: 359 SNDHEAIKDWVSQVFRDASSKHKEVYFGLKREYMEYDEVFSTVINDVRRELAADHTSPPA 418 Query: 221 LAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLY 280 M + +++I DP + + NL GDI SD A + GS+ S ++ L+ Sbjct: 419 FMIMRPSSQLIKMITDPPRSALYPAQNLDGDIFSDISAALGGSLATASSIIESKSSTMLF 478 Query: 281 EPAGGSAPDIA-------GKNIA-NPIAQILSLALLLRYSLDAD------DAACAIERAI 326 E G+A D+ GK+ NP A I +LA L + D + ++ A+ Sbjct: 479 EAPHGTAHDLYLKYLESNGKDAHFNPSALIYALANALETLGRRERNEALLDYSARLKAAL 538 Query: 327 NRALEEGIRTGDLARGAAAVSTDE---------MGDIIARYVAE 361 + +GI T DL +T E D I + + Sbjct: 539 KDTVGDGIVTADLKD---KTTTPESETLVDMMGFLDSIEKRLGS 579 >UniRef50_Q8T494 AT08722p n=1 Tax=Drosophila melanogaster RepID=Q8T494_DROME Length = 218 Score = 116 bits (290), Expect = 2e-24, Method: Composition-based stats. Identities = 52/222 (23%), Positives = 93/222 (41%), Gaps = 13/222 (5%) Query: 146 FGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESA-RKRRHKVTSIDKA-NVLQSSI 203 F + + G E V + ++ R AF++A + R +VT I+KA S Sbjct: 4 FNELEYSPVEGVVEA---LSVVSQKGNDKYLRYAFKAAAKAGRKRVTLINKAKEWPISDG 60 Query: 204 LWREIVNEIATEYPD-VELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITG 262 E + Y D +EL M ++ A +L+ +P+ FD L S + LS C+ + G Sbjct: 61 SLVEAAQRLHCHYKDCLELELMEVEEAISRLMTEPTYFDCLFASERYATFLSAICSGVCG 120 Query: 263 SMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIA-QILSLALLLRYSLDADDAACA 321 + + + + +++P ++ N AN A I+S + L L D A A Sbjct: 121 GANLFSAVEIGD-HHAVFKPLQ---TKLSLTNYANLSAYGIVSTIVDLFQHLGHDKCADA 176 Query: 322 IERAINRALEEGIRTGDLARG--AAAVSTDEMGDIIARYVAE 361 + + R + EGIRT + V + + + R + + Sbjct: 177 LWCELKRTMNEGIRTKEFGGQDTGEYVICNIINQLRCRALGK 218 >UniRef50_B8KHT3 Isocitrate dehydrogenase, NADP-dependent n=3 Tax=unclassified Gammaproteobacteria (miscellaneous) RepID=B8KHT3_9GAMM Length = 580 Score = 115 bits (289), Expect = 2e-24, Method: Composition-based stats. Identities = 49/238 (20%), Positives = 87/238 (36%), Gaps = 22/238 (9%) Query: 147 GQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARKRRHKVTSIDKANVLQSSILWR 206 G+ K + R I+ + F A + +V K + ++ Sbjct: 341 GEEKHARTVKSNDP-ILFMSNDRESIKDWVKQVFRDAALYKKEVYFGLKREFVNYDEVYS 399 Query: 207 EIVNEIATE-----YPDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMIT 261 I+ EI E P M ++I DP ++ + NL GDI SD A + Sbjct: 400 SIILEIRKELAALDTPPPSFMIMRPSRQLSKMICDPPRWGLYPAQNLDGDIFSDISAALG 459 Query: 262 GSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIA--------NPIAQILSLALLLRYSL 313 GS+ S ++ G L+E G+A D+ + + N A I ++A L Sbjct: 460 GSLATASSVIKSKDGTLLFEAPHGTAHDLYLRYLETDGKEANFNSSALIFAVANALEELA 519 Query: 314 DAD------DAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGD--IIARYVAEGV 363 + + A A++ A+ + +G TGDL A ++ + D + + Sbjct: 520 RREDNAPLAEYAEALKAALIETVAQGTITGDLKGKTLAPESETVVDMYGFLDAIESNL 577 Score = 56.1 bits (134), Expect = 2e-06, Method: Composition-based stats. Identities = 39/298 (13%), Positives = 83/298 (27%), Gaps = 59/298 (19%) Query: 1 MSKNYHI----AVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQP 56 M + + +L GD E+ A + + + I D+ Sbjct: 1 MGERIKVEKPLVILHGD----EMAQIAFERILEQFVTSRLDIQLVEVDLSAEQRLTSNGQ 56 Query: 57 LPPATVEGCEQADAVLFGSVGG-------------PKWEHLPPDQQPERGALLPLRKHFK 103 + +E + + + P+ D+ + +RK Sbjct: 57 VVLEAIEALKDHGIGVKNAGMTVNRSQLDEMLAKYPQINEAQLDKLATKSPNGAIRKGIG 116 Query: 104 LFSNL-RPAKLYQGLEAFCPLRADIAANGFDILCVRELTGGI---YF------GQPKGRE 153 N+ R ++ L + P + DI +GG+ Y G K Sbjct: 117 G--NITREDIEFRNLTSVRPDWVNR-----DIEVDTMESGGLDFSYSELSDATGVAKVMF 169 Query: 154 GSGQYEKAFDTEVYHRFE------------IERIARIAFESARKRRHKVTSIDKANVLQ- 200 + + ++ A F+ A + + K V+ Sbjct: 170 VGSSGDPVELHRRTLKKGDPWMLATNDLDDVKAWAHRFFQRALDEKRDIYLGLKDTVVPG 229 Query: 201 SSILWREIVNEI-------ATEYPDVELAHMYIDNATMQLIKDPSQFDVL-LCSNLFG 250 + R + EI E ++ + ID +++ +P Q + + N+ G Sbjct: 230 YDGVMRAAIEEIYVSDYRDKVEAAGLKYHYELIDAQAARIVSNPPQRALWGVPDNVSG 287 >UniRef50_B5KE47 4-hydroxythreonine-4-phosphate dehydrogenase n=1 Tax=Octadecabacter antarcticus 238 RepID=B5KE47_9RHOB Length = 343 Score = 105 bits (262), Expect = 3e-21, Method: Composition-based stats. Identities = 62/351 (17%), Positives = 116/351 (33%), Gaps = 54/351 (15%) Query: 1 MSKNYHIAVLPGD--GIGPEVMTQALK---VLDAVRNRFAMRITTSHYDVGGAAIDNHGQ 55 M+K IA++PGD GIGPE++ Q L V +A A + Sbjct: 6 MTK-PKIAIIPGDPSGIGPELIAQLLASDGVSEAADILLVGDTHIWEQGARQAGVRLQLD 64 Query: 56 PLPPATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQ 115 P+ A + + ++ + Q + AL L + L A + Sbjct: 65 PIAWANLAEFSGLRQLEMETIDVADVKVAEVTIQSGKSALRTLDQALDLAV----AGIVD 120 Query: 116 GLEAFCPLRADIAANGFDILCVRELTGGI------YFGQPKGREGSGQYEKAFDTEV--- 166 G+ +A + A G Y G + T V Sbjct: 121 GVLFGPFNKAALTAAGL-------NAEDEHRYMARYLGFKGYHSEVNVLDDLMTTRVTSH 173 Query: 167 ---------YHRFEIERIARIAFE-SARKRRHKVTSIDKA-NVLQSS--ILWREIVNEIA 213 + + +A + A+ + + A N RE ++ +A Sbjct: 174 IGLREVADNITADGVRKAIMMAHDTLAKAGKSRPHVAVAALNPHAGDNGKFGREEIDILA 233 Query: 214 TEYPDVELAHMYID----NATMQLIKDPSQFDVLLCSNLFGDILSDECAMITG---SMGM 266 + + HM++ + T+ L + D ++ ++ D + G + + Sbjct: 234 PVVAEYQGRHMHVSGPWPSDTVFLKAKAGEVDAVVT--MYHD-QGQIAIKLMGFDRGVTV 290 Query: 267 LPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADD 317 + + PA G+A DIAG+++AN A + LLLR ++ + Sbjct: 291 AGGLPI-----PVVTPAHGTAFDIAGQSVANVGATRNAFNLLLRLAVTHRE 336 >UniRef50_B6QRT7 3-isopropylmalate dehydrogenase, putative n=1 Tax=Penicillium marneffei ATCC 18224 RepID=B6QRT7_PENMQ Length = 158 Score = 105 bits (261), Expect = 4e-21, Method: Composition-based stats. Identities = 49/163 (30%), Positives = 80/163 (49%), Gaps = 11/163 (6%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAV-RNRFAMRITTSHYDVGGAAIDNHGQPLPP 59 M++ + VL GD IGPE++ +ALK L + R ++ + + GA++D +P+ Sbjct: 1 MAEIRKLLVLRGDRIGPEIIAEALKPLTVLVEERPDFKVQVRYGLLAGASLDKTNEPITD 60 Query: 60 ATVEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAK-LYQGLE 118 ++ DAVL GSVG P+W H+P PE+G +L LR+ F+N+RP + L Sbjct: 61 KVLDAALATDAVLLGSVGEPEWAHMPGALNPEKG-ILRLRQRLDAFANIRPCRFCASSLV 119 Query: 119 AFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKA 161 PL++D+ NG G Y + + G + Sbjct: 120 EQSPLKSDMV-NGV-------NFGEQYAARSRSTGGCCTKDIG 154 >UniRef50_B1XUL5 Tartrate dehydrogenase n=1 Tax=Polynucleobacter necessarius subsp. necessarius STIR1 RepID=B1XUL5_POLNS Length = 120 Score = 103 bits (256), Expect = 1e-20, Method: Composition-based stats. Identities = 45/123 (36%), Positives = 62/123 (50%), Gaps = 11/123 (8%) Query: 245 CSNLFGDILSDECAMITGSMGMLPSASLNEQG--FGLYEPAGGSAPDIAGKNIANPIAQI 302 N+FGDILSD TG++ + PS S+N +G L+EP GS PDI GK IANPI Q+ Sbjct: 1 MPNVFGDILSDLGPACTGTIAVAPSGSINPEGKFPSLFEPVHGSTPDIFGKMIANPIGQM 60 Query: 303 --LSLALLLRYSLDADDAACAIERAINRALEEG----IRTGDLARGAAAVSTDEMGDIIA 356 + ++ L + AI I + L G T DL + TD++G IA Sbjct: 61 ARFGVGAMILDHLGYPETGKAIFSVIEKVLSSGAGNAPLTPDL---GGSAKTDDLGKAIA 117 Query: 357 RYV 359 + Sbjct: 118 AAI 120 >UniRef50_C7GAF7 3-isopropylmalate dehydrogenase (Fragment) n=1 Tax=Roseburia intestinalis L1-82 RepID=C7GAF7_9FIRM Length = 115 Score = 101 bits (252), Expect = 4e-20, Method: Composition-based stats. Identities = 48/113 (42%), Positives = 64/113 (56%), Gaps = 5/113 (4%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 I V+ GDGIGPE++ +A KVLD + ++ +GG +ID G PL + Sbjct: 4 KIGVISGDGIGPEIVAEAKKVLDKIGTKYGHSFLYEAILMGGCSIDATGVPLTDEAIAAA 63 Query: 66 EQADAVLFGSVG----GPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLY 114 + +DAVL GS+G W L P+ +PE G LL LRK LF+NLRPA LY Sbjct: 64 KASDAVLMGSIGGNTATSPWYKLAPELRPEAG-LLKLRKSLNLFANLRPAYLY 115 >UniRef50_Q567A6 Isocitrate dehydrogenase 3 (NAD+) gamma n=1 Tax=Danio rerio RepID=Q567A6_DANRE Length = 289 Score = 92.7 bits (229), Expect = 2e-17, Method: Composition-based stats. Identities = 25/139 (17%), Positives = 49/139 (35%), Gaps = 20/139 (14%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 + + ++PGDGIGPE +L+ VR F ++V + + + Sbjct: 50 RHTVTLIPGDGIGPE-------LLNHVRELFRFSCVPVDFEVVHVNSSSTSEDDISNAIM 102 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPL 123 + L G++ H P + LR L++N+ + G++ Sbjct: 103 AIRRNGVALKGNIET---NHTMPPN--HKSRNNLLRTSLDLYANVMHCQSLPGVQT---- 153 Query: 124 RADIAANGFDILCVRELTG 142 DI+ + E + Sbjct: 154 ----RHKNIDIIIILEKSE 168 >UniRef50_Q8KH40 LeuB (Fragment) n=3 Tax=Buchnera aphidicola RepID=Q8KH40_9ENTR Length = 95 Score = 91.9 bits (227), Expect = 3e-17, Method: Composition-based stats. Identities = 44/85 (51%), Positives = 61/85 (71%), Gaps = 1/85 (1%) Query: 280 YEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDL 339 YEPAGGSAPDIAGKNIANPIAQILS+A+L+RY++ + IE A+ L++G RT D+ Sbjct: 11 YEPAGGSAPDIAGKNIANPIAQILSIAMLVRYTMKLPIISDQIESAVIDTLKKGYRTLDI 70 Query: 340 ARGAAAV-STDEMGDIIARYVAEGV 363 A ST+++GDII+ + + + Sbjct: 71 ANDKEKCESTNDIGDIISYILKKRI 95 >UniRef50_Q8N9Z6 cDNA FLJ36019 fis, clone TESTI2016421, highly similar to PROTEIN KINASE C-BINDING PROTEIN NELL1 n=1 Tax=Homo sapiens RepID=Q8N9Z6_HUMAN Length = 355 Score = 90.0 bits (222), Expect = 1e-16, Method: Composition-based stats. Identities = 25/114 (21%), Positives = 44/114 (38%), Gaps = 14/114 (12%) Query: 98 LRKHFKLFSNLRPAKLYQGLEAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGSGQ 157 L L++++ K +E + DIL V E T G Y + G Sbjct: 2 LHTTLDLYASVIHLKNLPNVETW--------HKDVDILVVWENTEGEYSNL-EHESVKGV 52 Query: 158 YEKAFDTEVYHRFEIERIARIAFESARKRR-HKVTSIDKANVLQ-SSILWREIV 209 E ++ + + RIA AF+ A+K KV ++ K N+ + + + Sbjct: 53 TE---SLKIMTKAKSLRIAEYAFQLAQKMGCKKVMAVHKVNITKLGDGPFLQCC 103 >UniRef50_B8ARP0 Putative uncharacterized protein n=1 Tax=Oryza sativa Indica Group RepID=B8ARP0_ORYSI Length = 359 Score = 88.8 bits (219), Expect = 2e-16, Method: Composition-based stats. Identities = 33/200 (16%), Positives = 55/200 (27%), Gaps = 37/200 (18%) Query: 91 ERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRADIAANGFDILCVRELTGGIYFGQPK 150 R +R P L + + I R G Y Sbjct: 31 WRSPNGTIRNILNGTVFREPI-LCKNVPRILSGWKKP------ICIGRHAFGDQYRATDT 83 Query: 151 GREGSGQYEKA--------------------FDTEVYHRFEIER-IARIAFESARKRRHK 189 G G+ + +Y+ E R A + A ++ Sbjct: 84 IINGPGKLKMVFVPDGAEPVELNVYNFKGPGVALSMYNVDESIRAFAESSMAMALSKKWP 143 Query: 190 VTSIDKANVLQ-SSILWREIVNEI-------ATEYPDVELAHMYIDNATMQLIKDPSQFD 241 + K +L+ +++I E+ E + H ID+ +K + Sbjct: 144 LYLSTKNTILKKYDGRFKDIFQEVYEEKWKEKFEENSIWYEHRLIDDMVAYAVKSEGGY- 202 Query: 242 VLLCSNLFGDILSDECAMIT 261 V C N GD+ SD A I Sbjct: 203 VWACKNYDGDVQSDFLAQIF 222 >UniRef50_C1GSN2 3-isopropylmalate dehydrogenase n=4 Tax=Onygenales RepID=C1GSN2_PARBA Length = 542 Score = 86.1 bits (212), Expect = 2e-15, Method: Composition-based stats. Identities = 37/102 (36%), Positives = 53/102 (51%), Gaps = 1/102 (0%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVE 63 + I VL GDGIG E+ +A+KVL + + + G +ID G P+ ++ Sbjct: 362 THTILVLRGDGIGLEITAEAVKVL-SAFSLKKRTFDLRSELIDGCSIDTDGTPITKTVIQ 420 Query: 64 GCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLF 105 +DAVLF SVGGPKW+ + D + G LL LRK + Sbjct: 421 AALDSDAVLFASVGGPKWDGVRHDLEGPEGGLLQLRKAMNQW 462 >UniRef50_Q84AT8 LeuB (Fragment) n=1 Tax=Buchnera aphidicola RepID=Q84AT8_9ENTR Length = 81 Score = 84.2 bits (207), Expect = 7e-15, Method: Composition-based stats. Identities = 39/80 (48%), Positives = 57/80 (71%), Gaps = 1/80 (1%) Query: 285 GSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDLAR-GA 343 GSAPDIAGKNIANPIAQILS+A+L+RY++ A IE ++ AL++G +T D+A Sbjct: 2 GSAPDIAGKNIANPIAQILSIAMLVRYTMKLHKIADDIESSVIDALKKGYKTLDIANVNE 61 Query: 344 AAVSTDEMGDIIARYVAEGV 363 +ST +MGD+I+ + + + Sbjct: 62 THISTSDMGDVISNILNKRI 81 >UniRef50_Q1G324 Putative uncharacterized protein n=1 Tax=Arabidopsis thaliana RepID=Q1G324_ARATH Length = 130 Score = 82.7 bits (203), Expect = 2e-14, Method: Composition-based stats. Identities = 32/76 (42%), Positives = 45/76 (59%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPAT 61 K Y IAVLPGDG+G EV+ A+ VL + + + +GG A+D G PLP T Sbjct: 38 KKRYTIAVLPGDGVGNEVIPVAVDVLCLAGSLEGIDFSFEELPIGGVALDLVGVPLPKET 97 Query: 62 VEGCEQADAVLFGSVG 77 + +Q+DA+L G+VG Sbjct: 98 LIRAKQSDALLLGAVG 113 >UniRef50_Q7X199 Lfe195p1 (Fragment) n=4 Tax=Leptospirillum RepID=Q7X199_9BACT Length = 197 Score = 81.5 bits (200), Expect = 4e-14, Method: Composition-based stats. Identities = 27/82 (32%), Positives = 41/82 (50%), Gaps = 5/82 (6%) Query: 283 AGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEE-GIRTGDLAR 341 GSAP AG NP A +LS ++L++ L+ +AA IE+ +++ L E T D Sbjct: 4 VHGSAPKYAGMKKVNPSAVLLSGVMMLKW-LNEHEAATRIEKGVDKVLAEAKHLTYD--- 59 Query: 342 GAAAVSTDEMGDIIARYVAEGV 363 STDE D I + + + Sbjct: 60 AGGTASTDEYADAIIKAMGNRL 81 >UniRef50_B6QD56 Putative uncharacterized protein n=1 Tax=Penicillium marneffei ATCC 18224 RepID=B6QD56_PENMQ Length = 106 Score = 79.2 bits (194), Expect = 2e-13, Method: Composition-based stats. Identities = 26/78 (33%), Positives = 40/78 (51%), Gaps = 1/78 (1%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRN-RFAMRITTSHYDVGGAAIDNHGQPLPPAT 61 K Y IA +PGD IGPEV+ + VL +++ R+ + D G A G+ +P Sbjct: 7 KTYKIASIPGDDIGPEVVNVIIDVLKSLQEILSTYRLEFTELDWGTARYKRTGKYMPADG 66 Query: 62 VEGCEQADAVLFGSVGGP 79 + + A +FG+VG P Sbjct: 67 LSTLKTFHAGIFGAVGAP 84 >UniRef50_A3RRN5 Tartrate dehydrogenase n=3 Tax=Ralstonia solanacearum RepID=A3RRN5_RALSO Length = 95 Score = 75.3 bits (184), Expect = 3e-12, Method: Composition-based stats. Identities = 31/81 (38%), Positives = 42/81 (51%), Gaps = 2/81 (2%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYD-VGGAAIDNHGQPLPP 59 MS +Y IAV+PGDGIG E + + L+V DA RF + H+D HG+ P Sbjct: 1 MS-SYRIAVIPGDGIGKEAVPERLRVPDAAARRFGFALHCGHFDFASSDTRARHGKLRPD 59 Query: 60 ATVEGCEQADAVLFGSVGGPK 80 + DA+ FG+VG P Sbjct: 60 DRFDTLRGYDALFFGAVGRPD 80 >UniRef50_A8PW52 Probable isocitrate dehydrogenase, putative n=1 Tax=Brugia malayi RepID=A8PW52_BRUMA Length = 104 Score = 75.0 bits (183), Expect = 4e-12, Method: Composition-based stats. Identities = 20/79 (25%), Positives = 32/79 (40%), Gaps = 4/79 (5%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGC 65 + ++PGDGIGPE+ + K+ +A I DV D+ +P +E Sbjct: 27 RVTLIPGDGIGPEISSSVQKIFEAANA----PIEWDPVDVTPVKGDDGIFRIPSKCIELM 82 Query: 66 EQADAVLFGSVGGPKWEHL 84 L G + P W+ Sbjct: 83 RINKIGLKGPLATPNWQRT 101 >UniRef50_UPI0001792E94 PREDICTED: similar to AGAP007786-PA n=1 Tax=Acyrthosiphon pisum RepID=UPI0001792E94 Length = 217 Score = 69.6 bits (169), Expect = 2e-10, Method: Composition-based stats. Identities = 20/66 (30%), Positives = 34/66 (51%), Gaps = 5/66 (7%) Query: 295 IANPIAQILSLALLLRYSLDADDAACAIERAINRALEEG-IRTGDLARGAAAVSTDEMGD 353 IANP A ++ + +LR+ ++ + +I AI L G +RT DL + ST E D Sbjct: 155 IANPTAMLMCASKMLRH-VNLQHYSESIRNAIREVLAAGKVRTRDL---GGSSSTHEFTD 210 Query: 354 IIARYV 359 + + + Sbjct: 211 AVIKAI 216 Score = 66.1 bits (160), Expect = 2e-09, Method: Composition-based stats. Identities = 21/106 (19%), Positives = 36/106 (33%), Gaps = 12/106 (11%) Query: 3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMR-ITTSHYDVGGAAIDNHGQPLPPAT 61 + ++PGDG+ PE+M VL A+ I S +A Sbjct: 63 ERITCTLIPGDGVYPELMNSVQTVLKAIGAPIDFETILFSEVQHSSSAKV-------EDV 115 Query: 62 VEGCEQADAVLFGSVGGPKWEHLPPDQQPERGALLPLRKHFKLFSN 107 ++ + L G++ P + + LRK L +N Sbjct: 116 IKSINRNRICLMGALMSPD----VSYSGELQNLHMKLRKGLDLIAN 157 >UniRef50_B8P335 Predicted protein (Fragment) n=4 Tax=Dikarya RepID=B8P335_POSPM Length = 83 Score = 69.2 bits (168), Expect = 2e-10, Method: Composition-based stats. Identities = 20/76 (26%), Positives = 33/76 (43%), Gaps = 6/76 (7%) Query: 5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEG 64 Y + ++PGDGIG E+ ++ + V I Y+V G + + G+ L VE Sbjct: 9 YTVTLIPGDGIGNEITDSVKEIFEYVNA----PIEWEQYNVSGMS--SAGEDLFKQAVES 62 Query: 65 CEQADAVLFGSVGGPK 80 + L G + P Sbjct: 63 LRRNRVGLKGILFTPI 78 >UniRef50_Q5D5H6 Isocitrate dehydrogenase, NAD-dependent (Fragment) n=2 Tax=Wolbachia RepID=Q5D5H6_9RICK Length = 212 Score = 67.3 bits (163), Expect = 8e-10, Method: Composition-based stats. Identities = 21/72 (29%), Positives = 30/72 (41%), Gaps = 4/72 (5%) Query: 294 NIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIRTGDL---ARGAAAVSTDE 350 NIANP + + +L Y + A I A + LE GI T DL R V T E Sbjct: 6 NIANPSGLLNAAVHMLIY-IGQVGTAKLIYDAWLKTLEGGIHTADLYKEKRSKQKVGTKE 64 Query: 351 MGDIIARYVAEG 362 + + + + Sbjct: 65 FAEAVIDNLGKK 76 >UniRef50_C6HDM5 Predicted protein n=1 Tax=Ajellomyces capsulatus H143 RepID=C6HDM5_AJECH Length = 168 Score = 67.3 bits (163), Expect = 9e-10, Method: Composition-based stats. Identities = 33/170 (19%), Positives = 55/170 (32%), Gaps = 36/170 (21%) Query: 69 DAVLFGSVGGPKWEHLPPDQQPERGALLPL---------------------RKHFKLFSN 107 DA L GSVG + + P + + R +L Sbjct: 6 DAYLLGSVGAARACMENTNINPYPSPIDAIGPSRPFFLIAILQTYLTISCSRVCLQL-VI 64 Query: 108 LRPAKLYQGLEAFCPLR--ADIAANGFDILCVRELTGGIYFGQPKGREGSGQYEKAFDTE 165 RP + Y P GF+ + V E G Y G S +E + Sbjct: 65 CRPREQYTNSNQQQPRSSLRGCQPRGFNWVIVPENPEGEYSGHSGRSHASKLWEMLITSG 124 Query: 166 VYHRFEIERIARIAFESARKRRHKVTSIDKANVLQSSILWREIVNEIATE 215 +++IA++ R + K+N ++ ++ I NE+A E Sbjct: 125 ---------LSKIAYQLLRGPEKHIAIATKSNAQRNGLV---IWNEVAAE 162 >UniRef50_UPI0001AF5761 3-isopropylmalate dehydrogenase n=1 Tax=Pseudomonas syringae pv. oryzae str. 1_6 RepID=UPI0001AF5761 Length = 59 Score = 64.2 bits (155), Expect = 7e-09, Method: Composition-based stats. Identities = 28/54 (51%), Positives = 38/54 (70%), Gaps = 2/54 (3%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHG 54 MSK I +LPGDGIGPE+MT+A+KVL+ ++ + +H +GGAAID HG Sbjct: 8 MSKQ--ILILPGDGIGPEIMTEAVKVLELANEKYQLGFELTHDVIGGAAIDKHG 59 >UniRef50_B5X9F9 Isocitrate dehydrogenase, mitochondrial n=6 Tax=cellular organisms RepID=B5X9F9_SALSA Length = 165 Score = 64.2 bits (155), Expect = 7e-09, Method: Composition-based stats. Identities = 10/106 (9%), Positives = 31/106 (29%), Gaps = 6/106 (5%) Query: 7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCE 66 + + GD E+ + + + + +YD+G D + + + Sbjct: 50 VVEMDGD----EMTRIIWEFIKEKLILSNVDVELKYYDLGLPYRDQTDDQVTIDSAIATQ 105 Query: 67 QADAVLFGSVGGPKWEHLPPD--QQPERGALLPLRKHFKLFSNLRP 110 + + + P + + ++ + +R P Sbjct: 106 KYHVAVKCATITPDEQRVEEFKLKKMWKSPNGTIRNILGGTVFREP 151 >UniRef50_D0DDP2 3-isopropylmalate dehydrogenase n=1 Tax=Citreicella sp. SE45 RepID=D0DDP2_9RHOB Length = 81 Score = 59.9 bits (144), Expect = 1e-07, Method: Composition-based stats. Identities = 23/43 (53%), Positives = 27/43 (62%) Query: 279 LYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACA 321 ++EPA GSAPDIAG+NIANPIA I S A +L A Sbjct: 1 MFEPAHGSAPDIAGRNIANPIAAIWSGAQMLERHRGGHRAGHR 43 >UniRef50_Q11SB4 Putative uncharacterized protein ttuC n=1 Tax=Cytophaga hutchinsonii ATCC 33406 RepID=Q11SB4_CYTH3 Length = 286 Score = 59.2 bits (142), Expect = 2e-07, Method: Composition-based stats. Identities = 29/117 (24%), Positives = 49/117 (41%), Gaps = 7/117 (5%) Query: 243 LLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQI 302 ++ S ++L A I S+ + E G+ + P G APDI G IANP A + Sbjct: 171 VVSSMEGANVLKALYASIYKSLNRAHTLIEVEDGY-ITMPMHGHAPDIVGMGIANPYALL 229 Query: 303 LSLALLLRYSLDADDAACAIERAINRALEE--GIRTGDLARGAAAVSTDEMGDIIAR 357 ++ LL ++ A +E I A E T D ++T++ ++ Sbjct: 230 MAFCRLL-TVAGYEELAQQVENQIESAFYENRDQTTPD---QGGVLNTEKYMAMMVE 282 >UniRef50_Q4V533 IP13250p (Fragment) n=8 Tax=melanogaster subgroup RepID=Q4V533_DROME Length = 475 Score = 57.2 bits (137), Expect = 8e-07, Method: Composition-based stats. Identities = 21/99 (21%), Positives = 37/99 (37%), Gaps = 13/99 (13%) Query: 96 LPLRKHFKLFSNLRPAKLYQGLEAFCPLRADIAANGFDILCVRELTGGIYFGQPKGREGS 155 L + L+ + + G + P G DI + + GI F + + Sbjct: 132 LKICNDLDLYVFKTRTRSFPGFKCRFP--------GVDIQLIGQNNMGI-FNELEYSPVE 182 Query: 156 GQYEKAFDTEVYHRFEIERIARIAFE-SARKRRHKVTSI 193 G E V + ++ R AF+ +A+ R +VT I Sbjct: 183 GVVEA---LSVVSQKGNDKYLRYAFKAAAKAGRKRVTLI 218 >UniRef50_B5E4Z3 3-isopropylmalate dehydrogenase, point mutation n=3 Tax=Streptococcus RepID=B5E4Z3_STRP4 Length = 51 Score = 55.3 bits (132), Expect = 3e-06, Method: Composition-based stats. Identities = 21/52 (40%), Positives = 27/52 (51%), Gaps = 2/52 (3%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDN 52 M+K I L GDGIGPE+M L+VL+A+ + GGA ID Sbjct: 1 MAK--KIVALAGDGIGPEIMEVGLEVLEALAEKTGFDYEIDRRPFGGADIDA 50 >UniRef50_UPI0001910A87 3-isopropylmalate dehydrogenase n=1 Tax=Salmonella enterica subsp. enterica serovar Typhi str. E98-2068 RepID=UPI0001910A87 Length = 51 Score = 54.5 bits (130), Expect = 6e-06, Method: Composition-based stats. Identities = 45/51 (88%), Positives = 49/51 (96%) Query: 313 LDADDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYVAEGV 363 +DAD+AA AIE+AINRALEEG+RT DLARGAAAVSTDEMGDIIARYVAEGV Sbjct: 1 MDADEAATAIEQAINRALEEGVRTSDLARGAAAVSTDEMGDIIARYVAEGV 51 >UniRef50_Q566P0 Zgc:113076 protein n=6 Tax=Deuterostomia RepID=Q566P0_DANRE Length = 66 Score = 54.2 bits (129), Expect = 8e-06, Method: Composition-based stats. Identities = 17/63 (26%), Positives = 27/63 (42%), Gaps = 5/63 (7%) Query: 301 QILSLALLLRYSLDADDAACAIERAINRAL-EEGIRTGDLARGAAAVSTDEMGDIIARYV 359 +L+ L+L + L D A I AI + E + T D+ +T E+ I R + Sbjct: 1 MLLASCLMLDH-LKLHDYANMIRSAILTTMNETRLHTVDIGGQG---TTSEVVQSIMRII 56 Query: 360 AEG 362 G Sbjct: 57 QSG 59 >UniRef50_P56471 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (Fragments) n=2 Tax=Laurasiatheria RepID=IDH3A_PIG Length = 90 Score = 53.4 bits (127), Expect = 1e-05, Method: Composition-based stats. Identities = 15/69 (21%), Positives = 27/69 (39%), Gaps = 4/69 (5%) Query: 6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRIT----TSHYDVGGAAIDNHGQPLPPAT 61 + ++PGDGIGPE+ +K+ DA + + Y +D + A Sbjct: 6 TVTLIPGDGIGPEISAAVMKIFDAAKAPIQANVRPCVSIEGYKFNEMYLDTVCLNIETAC 65 Query: 62 VEGCEQADA 70 + +D Sbjct: 66 FATIKCSDF 74 >UniRef50_P56472 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial (Fragments) n=1 Tax=Sus scrofa RepID=IDH3B_PIG Length = 103 Score = 49.5 bits (117), Expect = 2e-04, Method: Composition-based stats. Identities = 15/104 (14%), Positives = 36/104 (34%), Gaps = 28/104 (26%) Query: 256 ECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDA 315 + ++G++ L + GL+ ++ KNIANP A +L+ ++L + Sbjct: 25 VGPELMAAVGVIECLKLGD---GLFLQCCEEVAELYPKNIANPTATLLASCMMLDHL--- 78 Query: 316 DDAACAIERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYV 359 +T D+ + + + + + Sbjct: 79 -------------------KTSDM---GGYATCQDFTEAVIGAL 100 >UniRef50_A5LXH0 Putative uncharacterized protein n=1 Tax=Streptococcus pneumoniae SP9-BS68 RepID=A5LXH0_STRPN Length = 70 Score = 48.8 bits (115), Expect = 3e-04, Method: Composition-based stats. Identities = 16/42 (38%), Positives = 25/42 (59%), Gaps = 2/42 (4%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSH 42 M+K I L GDGIGPE+M L+VL+A+ + + + + Sbjct: 1 MAK--KIVALVGDGIGPEIMEAGLEVLEALAEKQVLTMRLTD 40 >UniRef50_Q0ZQ47 FrbB n=1 Tax=Streptomyces rubellomurinus RepID=Q0ZQ47_9ACTO Length = 352 Score = 48.4 bits (114), Expect = 4e-04, Method: Composition-based stats. Identities = 44/314 (14%), Positives = 89/314 (28%), Gaps = 35/314 (11%) Query: 17 PE--VMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCEQADAVLFG 74 PE V+ AL++L++ RI G LPP G Sbjct: 18 PEASVLPAALELLESAGLTANWRIVAGQAPDGDGGRKPEAGLLPPFAEPGASAYGL---- 73 Query: 75 SVGGPKWEHLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAFCPLRADIAANGFDI 134 + + RG L+ N+ + + + + Sbjct: 74 ARAARRAWGGTFSVIERRGPLVR----SDGTVNVLLFRYELDMSDTGMEFESNSGEQLAL 129 Query: 135 LCVRELTGGIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARK-RRHKVTSI 193 + + + A + + R A R+ + Sbjct: 130 V----------KTAAELGPREIPEQAALGIQAIAPDRVSEFVRTAVGMCRRLDVDDLVVA 179 Query: 194 DKAN-VLQSSILWREIVNEIATEYPD---VELAHMYIDNATMQLIKDPSQFDVLLCSNLF 249 K N + + L+ E + + ID+ +L+++P + +L + F Sbjct: 180 HKGNSIKHTDGLFALTAAETLESLAGAAGIAWRSLIIDHMAAELVRNPLDYRAILTHSSF 239 Query: 250 GDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANP-------IAQI 302 D+L+ A + + + + G L+ A D + + A+P +A Sbjct: 240 ADLLAAALAGQMTTDQLGVCTTYDPAGRPLF--GHDPALDTSAPD-ADPERWRVRRLAST 296 Query: 303 LSLALLLRYSLDAD 316 L+ L L Sbjct: 297 LAAGAALAEHLRLP 310 >UniRef50_Q9SF26 Putative dehydrogenase n=1 Tax=Arabidopsis thaliana RepID=Q9SF26_ARATH Length = 91 Score = 46.8 bits (110), Expect = 0.001, Method: Composition-based stats. Identities = 12/44 (27%), Positives = 16/44 (36%) Query: 2 SKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDV 45 S + PGDGIGPE+ +V A +V Sbjct: 41 STPIKATLFPGDGIGPEIAESVKQVFTAADVVIDWDEQFVGTEV 84 >UniRef50_D2H627 Putative uncharacterized protein n=1 Tax=Ailuropoda melanoleuca RepID=D2H627_AILME Length = 185 Score = 46.8 bits (110), Expect = 0.001, Method: Composition-based stats. Identities = 8/75 (10%), Positives = 22/75 (29%), Gaps = 3/75 (4%) Query: 48 AAIDNHGQPLPPATVEGCEQADAVLFGSVGGPKWEHLPPD--QQPERGALLPLRKHFKLF 105 D + E ++ +A + + P + + +Q + +R Sbjct: 107 ENHDATNDQVTKDAAEAIKKYNAGVKCAAITPDEKRVEEFKLKQMWKSPNGTIRNILGGT 166 Query: 106 SNLRPAKLYQGLEAF 120 R A + + + Sbjct: 167 V-FREAIICKNIPRL 180 >UniRef50_Q9H302 NADP+-specific isocitrate dehydrogenase (Fragment) n=3 Tax=Eutheria RepID=Q9H302_HUMAN Length = 127 Score = 46.5 bits (109), Expect = 0.001, Method: Composition-based stats. Identities = 17/83 (20%), Positives = 30/83 (36%), Gaps = 15/83 (18%) Query: 296 ANPIAQILSLALLL------RYSLDADDAACAIERAINRALEEGIRTGDL---------A 340 NPIA I + L + + A A+E +E G T DL A Sbjct: 5 TNPIASIFAWTRGLALRAKTDNNKELAFFANALEEVCIETIEAGFMTKDLAACIKGLPSA 64 Query: 341 RGAAAVSTDEMGDIIARYVAEGV 363 + + ++T E + + + + Sbjct: 65 QCSDYLNTFEFMEKLGENLKIKL 87 >UniRef50_Q4VCC2 Isocitrate dehydrogenase (Fragment) n=1 Tax=Saltugilia latimeri RepID=Q4VCC2_9ERIC Length = 158 Score = 46.1 bits (108), Expect = 0.002, Method: Composition-based stats. Identities = 11/70 (15%), Positives = 25/70 (35%), Gaps = 8/70 (11%) Query: 168 HRFEIERIARIAFESARKRRHKVTSIDKANVLQ-SSILWREIVNEIAT-------EYPDV 219 I A + +A +++ + K +L+ +++I E+ E + Sbjct: 1 TDESIYSFAEASMTTAYEKKWPLYLSTKNTILKKYDGRFKDIFQEVYEKSWKSKYEAAGI 60 Query: 220 ELAHMYIDNA 229 H ID+ Sbjct: 61 WYEHRLIDDM 70 >UniRef50_Q6UB50 Putative dehydrogenase (Fragment) n=1 Tax=Hyaloperonospora parasitica RepID=Q6UB50_9STRA Length = 55 Score = 45.3 bits (106), Expect = 0.003, Method: Composition-based stats. Identities = 19/51 (37%), Positives = 28/51 (54%), Gaps = 1/51 (1%) Query: 311 YSLDADDAACAIERAINRALEEGIRTGDLARGAAA-VSTDEMGDIIARYVA 360 YS + A IE+A+ + L +G+RTGDL + +A V T MG I + Sbjct: 1 YSFQMETEAQLIEKAVEQVLLDGMRTGDLTKDKSAVVGTKTMGAAIIAKMK 51 >UniRef50_D1J805 Signal recognition particle protein (Fifty fourhomolog) n=4 Tax=Mycoplasma RepID=D1J805_MYCHP Length = 442 Score = 45.3 bits (106), Expect = 0.004, Method: Composition-based stats. Identities = 33/194 (17%), Positives = 65/194 (33%), Gaps = 28/194 (14%) Query: 143 GIYFGQPKGREGSGQYEKAFDTEVYHRFEIERIARIAFESARKRRHKVTSIDKANVLQSS 202 IY + + + D IA+ A E A++ ++ + ID A L Sbjct: 138 DIYRPAAREQLQQLAKQTQTDFFTMEENNAINIAQKAIELAKENKNDLVIIDTAGRLAID 197 Query: 203 ILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLLCS-------NLFGDILSD 255 + + +I +Y + + +D + Q DV+ + NL G I++ Sbjct: 198 ENLMQELKDI-KKYTHPDYIFLVVDAMSGQ--------DVINTAKIFHQELNLDGTIITK 248 Query: 256 ECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDA 315 + G + + LN ++ G+ + G + +P + L Sbjct: 249 LDSDARGGAALSITHLLNV--PIIF---IGTGEKLTGLELFHP-------DRMADRILGM 296 Query: 316 DDAACAIERAINRA 329 D IE+A Sbjct: 297 GDVLTLIEKASEEV 310 >UniRef50_Q2VF40 Isocitrate dehydrogenase 3 gamma subunit (Fragment) n=1 Tax=Pan troglodytes RepID=Q2VF40_PANTR Length = 165 Score = 44.9 bits (105), Expect = 0.005, Method: Composition-based stats. Identities = 10/26 (38%), Positives = 15/26 (57%) Query: 4 NYHIAVLPGDGIGPEVMTQALKVLDA 29 + + ++PGDGIGPE+M V Sbjct: 112 RHTVTMIPGDGIGPELMLHVKSVFRY 137 >UniRef50_C5K691 Nadp-specific isocitrate dehydrogenase, putative (Fragment) n=1 Tax=Perkinsus marinus ATCC 50983 RepID=C5K691_9ALVE Length = 113 Score = 44.9 bits (105), Expect = 0.005, Method: Composition-based stats. Identities = 17/86 (19%), Positives = 32/86 (37%), Gaps = 15/86 (17%) Query: 293 KNIANPIAQILSLALLLRYSL------DADDAACAIERAINRALEEGIRTGDLA------ 340 K NPIA I + + L A A+E A ++E G + DLA Sbjct: 3 KTSTNPIASIFAWSRALNQRAILDDNSRLKHFAQALEEACIESVEAGYMSKDLAICVAGT 62 Query: 341 ---RGAAAVSTDEMGDIIARYVAEGV 363 ++++++ D + + + Sbjct: 63 SKVSSEQYLTSEDLIDYFSERLKVKL 88 >UniRef50_C0BPH4 3-isopropylmalate dehydrogenase n=1 Tax=Flavobacteria bacterium MS024-3C RepID=C0BPH4_9BACT Length = 105 Score = 44.5 bits (104), Expect = 0.005, Method: Composition-based stats. Identities = 30/84 (35%), Positives = 42/84 (50%), Gaps = 4/84 (4%) Query: 276 GFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERAINRALEEGIR 335 G L+EP S + K NPI I SLALLL + A AI+ A+N A E G+ Sbjct: 4 GINLFEPLEDSQSTL--KEKVNPIPLIYSLALLLS-RFGLQEEAGAIQMAVNSAGERGMY 60 Query: 336 TGDLARGAAAVSTDEMGDIIARYV 359 T L ++ D++GD +A + Sbjct: 61 TT-LDTLPKDINCDQLGDYLAAAI 83 >UniRef50_B7BAU1 Putative uncharacterized protein (Fragment) n=1 Tax=Parabacteroides johnsonii DSM 18315 RepID=B7BAU1_9PORP Length = 52 Score = 44.5 bits (104), Expect = 0.005, Method: Composition-based stats. Identities = 15/50 (30%), Positives = 22/50 (44%), Gaps = 3/50 (6%) Query: 313 LDADDAACAIERAINRALEEGIRTGDLAR---GAAAVSTDEMGDIIARYV 359 + ++A I A+ A EG T DLAR + T E G+ I + Sbjct: 3 MGWNEAGRLITAALEHAFSEGKATRDLARFMPNGQPLGTKEFGEYIMSVL 52 >UniRef50_Q1M832 Putative uncharacterized protein n=1 Tax=Rhizobium leguminosarum bv. viciae 3841 RepID=Q1M832_RHIL3 Length = 85 Score = 43.4 bits (101), Expect = 0.013, Method: Composition-based stats. Identities = 11/51 (21%), Positives = 21/51 (41%), Gaps = 4/51 (7%) Query: 311 YSLDADDAACAIERAINRALE-EGIRTGDLARGAAAVSTDEMGDIIARYVA 360 + + + A AI A+ + L + +RT + +T E R +A Sbjct: 38 HHVGEGEKANAIRNAVEKVLNIDNVRT---GGLGGSATTKEFTAATERRLA 85 >UniRef50_D1Z545 Whole genome shotgun sequence assembly, scaffold_4 n=1 Tax=Sordaria macrospora RepID=D1Z545_SORMA Length = 165 Score = 42.2 bits (98), Expect = 0.032, Method: Composition-based stats. Identities = 12/33 (36%), Positives = 21/33 (63%), Gaps = 1/33 (3%) Query: 189 KVTSIDKANVLQ-SSILWREIVNEIATEYPDVE 220 KVT I KAN+++ + L+ N +A ++P +E Sbjct: 79 KVTCIHKANIMKLADGLFHGTFNRLAKDFPQLE 111 >UniRef50_A7IS87 LeuB (Fragment) n=1 Tax=Neisseria meningitidis RepID=A7IS87_NEIME Length = 44 Score = 41.1 bits (95), Expect = 0.068, Method: Composition-based stats. Identities = 17/47 (36%), Positives = 29/47 (61%), Gaps = 3/47 (6%) Query: 1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGG 47 M+K HIA+L GDGIG E++ + ++VLD + + + + +GG Sbjct: 1 MTK--HIAILRGDGIGSEIVAETVRVLDKLIAQ-GLDAGYEYAPLGG 44 Database: uniref50.fasta Posted date: Mar 8, 2010 10:38 AM Number of letters in database: 1,040,396,356 Number of sequences in database: 3,077,464 Lambda K H 0.312 0.147 0.403 Lambda K H 0.267 0.0451 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 2,300,364,476 Number of Sequences: 3077464 Number of extensions: 98869337 Number of successful extensions: 282016 Number of sequences better than 1.0e-01: 240 Number of HSP's better than 0.1 without gapping: 586 Number of HSP's successfully gapped in prelim test: 79 Number of HSP's that attempted gapping in prelim test: 278220 Number of HSP's gapped (non-prelim): 749 length of query: 363 length of database: 1,040,396,356 effective HSP length: 130 effective length of query: 233 effective length of database: 640,326,036 effective search space: 149195966388 effective search space used: 149195966388 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 94 (40.7 bits)