Phyre 2 Results for P33018

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Email | l.a.kelley@imperial.ac.uk
Description | P33018
Date | Thu Jan 5 11:50:53 GMT 2012
Unique Job ID | 90e3712bb31b4cb5

Summary |

Top model
Image coloured by rainbow N → C terminus
| Close Jmol

Model (left) based on template c3e4dD_
Top template information
PDB header:hydrolase Chain: D: PDB Molecule:esterase d; PDBTitle: structural and kinetic study of an s-formylglutathione2 hydrolase from agrobacterium tumefaciens
Confidence and coverage
Confidence: | 100.0% | Coverage: | 98%
272 residues ( 98% of your sequence) have been modelled with 100.0% confidence by the single highest scoring template.
3D viewing
Interactive 3D view in Jmol

Sequence analysis |

Secondary structure and disorder prediction |

|  | 1 | . | . | . | . | . | . | . | . | 10 | . | . | . | . | . | . | . | . | . | 20 | . | . | . | . | . | . | . | . | . | 30 | . | . | . | . | . | . | . | . | . | 40 | . | . | . | . | . | . | . | . | . | 50 | . | . | . | . | . | . | . | . | . | 60
Sequence |  | M | E | M | L | E | E | H | R | C | F | E | G | W | Q | Q | R | W | R | H | D | S | S | T | L | N | C | P | M | T | F | S | I | F | L | P | P | P | R | D | H | T | P | P | P | V | L | Y | W | L | S | G | L | T | C | N | D | E | N | F | T
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  | ? | ? | ? | ? | ? | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 70 | . | . | . | . | . | . | . | . | . | 80 | . | . | . | . | . | . | . | . | . | 90 | . | . | . | . | . | . | . | . | . | 100 | . | . | . | . | . | . | . | . | . | 110 | . | . | . | . | . | . | . | . | . | 120
Sequence |  | T | K | A | G | A | Q | R | V | A | A | E | L | G | I | V | L | V | M | P | D | T | S | P | R | G | E | K | V | A | N | D | D | G | Y | D | L | G | Q | G | A | G | F | Y | L | N | A | T | Q | P | P | W | A | T | H | Y | R | M | Y | D | Y
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ? | ? |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 130 | . | . | . | . | . | . | . | . | . | 140 | . | . | . | . | . | . | . | . | . | 150 | . | . | . | . | . | . | . | . | . | 160 | . | . | . | . | . | . | . | . | . | 170 | . | . | . | . | . | . | . | . | . | 180
Sequence |  | L | R | D | E | L | P | A | L | V | Q | S | Q | F | N | V | S | D | R | C | A | I | S | G | H | S | M | G | G | H | G | A | L | I | M | A | L | K | N | P | G | K | Y | T | S | V | S | A | F | A | P | I | V | N | P | C | S | V | P | W | G
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 190 | . | . | . | . | . | . | . | . | . | 200 | . | . | . | . | . | . | . | . | . | 210 | . | . | . | . | . | . | . | . | . | 220 | . | . | . | . | . | . | . | . | . | 230 | . | . | . | . | . | . | . | . | . | 240
Sequence |  | I | K | A | F | S | S | Y | L | G | E | D | K | N | A | W | L | E | W | D | S | C | A | L | M | Y | A | S | N | A | Q | D | A | I | P | T | L | I | D | Q | G | D | N | D | Q | F | L | A | D | Q | L | Q | P | A | V | L | A | E | A | A | R
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
|  | . | . | . | . | . | . | . | . | . | 250 | . | . | . | . | . | . | . | . | . | 260 | . | . | . | . | . | . | . | . | . | 270 | . | . | . | . | . | . | . | .
Sequence |  | Q | K | A | W | P | M | T | L | R | I | Q | P | G | Y | D | H | S | Y | Y | F | I | A | S | F | I | E | D | H | L | R | F | H | A | Q | Y | L | L | K
Secondary structure |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
SS confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Disorder |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | ? | ? | ?
Disorder confidence |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |

Confidence Key
High(9) |  |  |  |  |  |  |  |  |  |  | Low (0)

? | Disordered
| Alpha helix
| Beta strand

Domain analysis |

Hover over an aligned region to see model and summary info

Please note, only up to the top 20 hits are modelled to reduce computer load

Rank | Aligned region
--- | ---
1 |
| c3e4dD_ |

### PDB 3e4d chain D

Region: 3 - 276
Aligned: 272
Modelled: 274
Confidence: 100.0%
Identity: 46%
PDB header:hydrolase
Chain: D: PDB Molecule:esterase d;
PDBTitle: structural and kinetic study of an s-formylglutathione2 hydrolase from agrobacterium tumefaciens

Phyre2
2 |
| d1pv1a_ |

### PDB 1pv1 chain A

Region: 1 - 276
Aligned: 272
Modelled: 276
Confidence: 100.0%
Identity: 46%
Fold: alpha/beta-Hydrolases
Superfamily: alpha/beta-Hydrolases
Family: Hypothetical esterase YJL068C

Phyre2
3 |
| c3ls2D_ |

### PDB 3ls2 chain D

Region: 1 - 276
Aligned: 276
Modelled: 276
Confidence: 100.0%
Identity: 56%
PDB header:hydrolase
Chain: D: PDB Molecule:s-formylglutathione hydrolase;
PDBTitle: crystal structure of an s-formylglutathione hydrolase from2 pseudoalteromonas haloplanktis tac125

Phyre2
4 |
| c3i6yA_ |

### PDB 3i6y chain A

Region: 1 - 277
Aligned: 275
Modelled: 277
Confidence: 100.0%
Identity: 61%
PDB header:hydrolase
Chain: A: PDB Molecule:esterase apc40077;
PDBTitle: structure of an esterase from the oil-degrading bacterium oleispira2 antarctica

Phyre2
5 |
| c3fcxA_ |

### PDB 3fcx chain A

Region: 1 - 277
Aligned: 263
Modelled: 270
Confidence: 100.0%
Identity: 52%
PDB header:hydrolase
Chain: A: PDB Molecule:s-formylglutathione hydrolase;
PDBTitle: crystal structure of human esterase d

Phyre2
6 |
| d1dqza_ |

### PDB 1dqz chain A

Region: 10 - 277
Aligned: 249
Modelled: 250
Confidence: 100.0%
Identity: 16%
Fold: alpha/beta-Hydrolases
Superfamily: alpha/beta-Hydrolases
Family: Mycobacterial antigens

Phyre2
7 |
| c1z68A_ |

### PDB 1z68 chain A

Region: 15 - 277
Aligned: 248
Modelled: 249
Confidence: 100.0%
Identity: 15%
PDB header:lyase
Chain: A: PDB Molecule:fibroblast activation protein, alpha subunit;
PDBTitle: crystal structure of human fibroblast activation protein alpha

Phyre2
8 |
| c2ecfA_ |

### PDB 2ecf chain A

Region: 14 - 276
Aligned: 245
Modelled: 249
Confidence: 100.0%
Identity: 16%
PDB header:hydrolase
Chain: A: PDB Molecule:dipeptidyl peptidase iv;
PDBTitle: crystal structure of dipeptidyl aminopeptidase iv from2 stenotrophomonas maltophilia

Phyre2
9 |
| c2qtbB_ |

### PDB 2qtb chain B

Region: 14 - 277
Aligned: 248
Modelled: 250
Confidence: 100.0%
Identity: 15%
PDB header:hydrolase
Chain: B: PDB Molecule:dipeptidyl peptidase 4;
PDBTitle: human dipeptidyl peptidase iv/cd26 in complex with a 4-aryl2 cyclohexylalanine inhibitor

Phyre2
10 |
| d1jjfa_ |

### PDB 1jjf chain A

Region: 11 - 274
Aligned: 219
Modelled: 222
Confidence: 100.0%
Identity: 19%
Fold: alpha/beta-Hydrolases
Superfamily: alpha/beta-Hydrolases
Family: Carboxylesterase

Phyre2
11 |
| d1f0na_ |

### PDB 1f0n chain A

Region: 10 - 276
Aligned: 251
Modelled: 255
Confidence: 100.0%
Identity: 15%
Fold: alpha/beta-Hydrolases
Superfamily: alpha/beta-Hydrolases
Family: Mycobacterial antigens

Phyre2
12 |
| d1sfra_ |

### PDB 1sfr chain A

Region: 8 - 276
Aligned: 253
Modelled: 253
Confidence: 100.0%
Identity: 17%
Fold: alpha/beta-Hydrolases
Superfamily: alpha/beta-Hydrolases
Family: Mycobacterial antigens

Phyre2
13 |
| c2g5tA_ |

### PDB 2g5t chain A

Region: 15 - 277
Aligned: 248
Modelled: 249
Confidence: 100.0%
Identity: 15%
PDB header:hydrolase
Chain: A: PDB Molecule:dipeptidyl peptidase 4;
PDBTitle: crystal structure of human dipeptidyl peptidase iv (dppiv)2 complexed with cyanopyrrolidine (c5-pro-pro) inhibitor 21ag

Phyre2
14 |
| c2eepA_ |

### PDB 2eep chain A

Region: 4 - 276
Aligned: 255
Modelled: 259
Confidence: 100.0%
Identity: 14%
PDB header:hydrolase
Chain: A: PDB Molecule:dipeptidyl aminopeptidase iv, putative;
PDBTitle: prolyl tripeptidyl aminopeptidase complexed with an inhibitor

Phyre2
15 |
| d3c8da2 |

### PDB 3c8d chain A domain 2

Region: 8 - 276
Aligned: 222
Modelled: 230
Confidence: 100.0%
Identity: 18%
Fold: alpha/beta-Hydrolases
Superfamily: alpha/beta-Hydrolases
Family: Carboxylesterase

Phyre2
16 |
| c2uz0B_ |

### PDB 2uz0 chain B

Region: 13 - 278
Aligned: 234
Modelled: 241
Confidence: 100.0%
Identity: 18%
PDB header:hydrolase
Chain: B: PDB Molecule:tributyrin esterase;
PDBTitle: the crystal crystal structure of the esta protein, a2 virulence factor esta protein from streptococcus pneumonia

Phyre2
17 |
| c3azqA_ |

### PDB 3azq chain A

Region: 12 - 276
Aligned: 246
Modelled: 251
Confidence: 100.0%
Identity: 14%
PDB header:hydrolase
Chain: A: PDB Molecule:aminopeptidase;
PDBTitle: crystal structure of puromycin hydrolase s511a mutant complexed with2 pgg

Phyre2
18 |
| d1r88a_ |

### PDB 1r88 chain A

Region: 12 - 276
Aligned: 240
Modelled: 240
Confidence: 100.0%
Identity: 17%
Fold: alpha/beta-Hydrolases
Superfamily: alpha/beta-Hydrolases
Family: Mycobacterial antigens

Phyre2
19 |
| c1qfmA_ |

### PDB 1qfm chain A

Region: 13 - 277
Aligned: 249
Modelled: 251
Confidence: 100.0%
Identity: 15%
PDB header:hydrolase
Chain: A: PDB Molecule:protein (prolyl oligopeptidase);
PDBTitle: prolyl oligopeptidase from porcine muscle

Phyre2
20 |
| c1wb4A_ |

### PDB 1wb4 chain A

Region: 11 - 278
Aligned: 226
Modelled: 228
Confidence: 100.0%
Identity: 15%
PDB header:hydrolase
Chain: A: PDB Molecule:endo-1,4-beta-xylanase y;
PDBTitle: s954a mutant of the feruloyl esterase module from2 clostridium thermocellum complexed with sinapinate

Phyre2
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Detailed template information |

# | Template | Alignment Coverage | 3D Model | Confidence | % i.d. | Template Information
--- | --- | --- | --- | --- | --- | ---
1 | c3e4dD_ |
|  | 100.0 | 46 | PDB header:hydrolase Chain: D: PDB Molecule:esterase d; PDBTitle: structural and kinetic study of an s-formylglutathione2 hydrolase from agrobacterium tumefaciens
2 | d1pv1a_ |
|  | 100.0 | 46 | Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Hypothetical esterase YJL068C
3 | c3ls2D_ |
|  | 100.0 | 56 | PDB header:hydrolase Chain: D: PDB Molecule:s-formylglutathione hydrolase; PDBTitle: crystal structure of an s-formylglutathione hydrolase from2 pseudoalteromonas haloplanktis tac125
4 | c3i6yA_ |
|  | 100.0 | 61 | PDB header:hydrolase Chain: A: PDB Molecule:esterase apc40077; PDBTitle: structure of an esterase from the oil-degrading bacterium oleispira2 antarctica
5 | c3fcxA_ |
|  | 100.0 | 52 | PDB header:hydrolase Chain: A: PDB Molecule:s-formylglutathione hydrolase; PDBTitle: crystal structure of human esterase d
6 | d1dqza_ |
|  | 100.0 | 16 | Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Mycobacterial antigens
7 | c1z68A_ |
|  | 100.0 | 15 | PDB header:lyase Chain: A: PDB Molecule:fibroblast activation protein, alpha subunit; PDBTitle: crystal structure of human fibroblast activation protein alpha
8 | c2ecfA_ |
|  | 100.0 | 16 | PDB header:hydrolase Chain: A: PDB Molecule:dipeptidyl peptidase iv; PDBTitle: crystal structure of dipeptidyl aminopeptidase iv from2 stenotrophomonas maltophilia
9 | c2qtbB_ |
|  | 100.0 | 15 | PDB header:hydrolase Chain: B: PDB Molecule:dipeptidyl peptidase 4; PDBTitle: human dipeptidyl peptidase iv/cd26 in complex with a 4-aryl2 cyclohexylalanine inhibitor
10 | d1jjfa_ |
|  | 100.0 | 19 | Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Carboxylesterase
11 | d1f0na_ |
|  | 100.0 | 15 | Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Mycobacterial antigens
12 | d1sfra_ |
|  | 100.0 | 17 | Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Mycobacterial antigens
13 | c2g5tA_ |
|  | 100.0 | 15 | PDB header:hydrolase Chain: A: PDB Molecule:dipeptidyl peptidase 4; PDBTitle: crystal structure of human dipeptidyl peptidase iv (dppiv)2 complexed with cyanopyrrolidine (c5-pro-pro) inhibitor 21ag
14 | c2eepA_ |
|  | 100.0 | 14 | PDB header:hydrolase Chain: A: PDB Molecule:dipeptidyl aminopeptidase iv, putative; PDBTitle: prolyl tripeptidyl aminopeptidase complexed with an inhibitor
15 | d3c8da2 |
|  | 100.0 | 18 | Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Carboxylesterase
16 | c2uz0B_ |
|  | 100.0 | 18 | PDB header:hydrolase Chain: B: PDB Molecule:tributyrin esterase; PDBTitle: the crystal crystal structure of the esta protein, a2 virulence factor esta protein from streptococcus pneumonia
17 | c3azqA_ |
|  | 100.0 | 14 | PDB header:hydrolase Chain: A: PDB Molecule:aminopeptidase; PDBTitle: crystal structure of puromycin hydrolase s511a mutant complexed with2 pgg
18 | d1r88a_ |
|  | 100.0 | 17 | Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Mycobacterial antigens
19 | c1qfmA_ |
|  | 100.0 | 15 | PDB header:hydrolase Chain: A: PDB Molecule:protein (prolyl oligopeptidase); PDBTitle: prolyl oligopeptidase from porcine muscle
20 | c1wb4A_ |
|  | 100.0 | 15 | PDB header:hydrolase Chain: A: PDB Molecule:endo-1,4-beta-xylanase y; PDBTitle: s954a mutant of the feruloyl esterase module from2 clostridium thermocellum complexed with sinapinate
21 | c3c8dA_ |
| not modelled | 100.0 | 18 | PDB header:hydrolase Chain: A: PDB Molecule:enterochelin esterase; PDBTitle: crystal structure of the enterobactin esterase fes from2 shigella flexneri in the presence of 2,3-di-hydroxy-n-3 benzoyl-glycine
22 | c2xe4A_ |
| not modelled | 100.0 | 14 | PDB header:hydrolase/inhibitor Chain: A: PDB Molecule:oligopeptidase b; PDBTitle: structure of oligopeptidase b from leishmania major
23 | c2bklB_ |
| not modelled | 100.0 | 15 | PDB header:hydrolase Chain: B: PDB Molecule:prolyl endopeptidase; PDBTitle: structural and mechanistic analysis of two prolyl2 endopeptidases: role of inter-domain dynamics in3 catalysis and specificity
24 | c2hu7A_ |
| not modelled | 100.0 | 16 | PDB header:hydrolase Chain: A: PDB Molecule:acylamino-acid-releasing enzyme; PDBTitle: binding of inhibitors by acylaminoacyl peptidase
25 | c1xfdD_ |
| not modelled | 100.0 | 16 | PDB header:membrane protein Chain: D: PDB Molecule:dipeptidyl aminopeptidase-like protein 6; PDBTitle: structure of a human a-type potassium channel accelerating factor2 dppx, a member of the dipeptidyl aminopeptidase family
26 | c3iumA_ |
| not modelled | 100.0 | 14 | PDB header:hydrolase Chain: A: PDB Molecule:prolyl endopeptidase; PDBTitle: appep_wtx opened state
27 | d1wb4a1 |
| not modelled | 100.0 | 15 | Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Carboxylesterase
28 | c3doiA_ |
| not modelled | 100.0 | 13 | PDB header:hydrolase Chain: A: PDB Molecule:esterase; PDBTitle: crystal structure of a thermostable esterase complex with2 paraoxon
29 | c1yr2A_ |
| not modelled | 100.0 | 15 | PDB header:hydrolase Chain: A: PDB Molecule:prolyl oligopeptidase; PDBTitle: structural and mechanistic analysis of two prolyl endopeptidases: role2 of inter-domain dynamics in catalysis and specificity
30 | c3gffA_ |
| not modelled | 100.0 | 18 | PDB header:hydrolase Chain: A: PDB Molecule:iroe-like serine hydrolase; PDBTitle: crystal structure of iroe-like serine hydrolase (np_718593.1) from2 shewanella oneidensis at 2.12 a resolution
31 | c2qm0B_ |
| not modelled | 100.0 | 14 | PDB header:structural genomics, unknown function Chain: B: PDB Molecule:bes; PDBTitle: crystal structure of bes protein from bacillus cereus
32 | d1orva2 |
| not modelled | 100.0 | 15 | Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:DPP6 catalytic domain-like
33 | d1qfma2 |
| not modelled | 100.0 | 14 | Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Prolyl oligopeptidase, C-terminal domain
34 | d2bgra2 |
| not modelled | 100.0 | 15 | Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:DPP6 catalytic domain-like
35 | d2gzsa1 |
| not modelled | 100.0 | 16 | Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:IroE-like
36 | c3bxpA_ |
| not modelled | 100.0 | 11 | PDB header:hydrolase Chain: A: PDB Molecule:putative lipase/esterase; PDBTitle: crystal structure of a putative carboxylesterase (lp_2923) from2 lactobacillus plantarum wcfs1 at 1.70 a resolution
37 | c3ed1E_ |
| not modelled | 100.0 | 15 | PDB header:hydrolase receptor Chain: E: PDB Molecule:gibberellin receptor gid1; PDBTitle: crystal structure of rice gid1 complexed with ga3
38 | d2hu7a2 |
| not modelled | 100.0 | 15 | Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Acylamino-acid-releasing enzyme, C-terminal donain
39 | d1xfda2 |
| not modelled | 99.9 | 16 | Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:DPP6 catalytic domain-like
40 | c3k2iA_ |
| not modelled | 99.9 | 16 | PDB header:hydrolase Chain: A: PDB Molecule:acyl-coenzyme a thioesterase 4; PDBTitle: human acyl-coenzyme a thioesterase 4
41 | c2o7vA_ |
| not modelled | 99.9 | 17 | PDB header:hydrolase Chain: A: PDB Molecule:cxe carboxylesterase; PDBTitle: carboxylesterase aecxe1 from actinidia eriantha covalently inhibited2 by paraoxon
42 | c2zshA_ |
| not modelled | 99.9 | 16 | PDB header:hormone receptor Chain: A: PDB Molecule:probable gibberellin receptor gid1l1; PDBTitle: structural basis of gibberellin(ga3)-induced della2 recognition by the gibberellin receptor
43 | d2h1ia1 |
| not modelled | 99.9 | 16 | Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Carboxylesterase/thioesterase 1
44 | c3hlkB_ |
| not modelled | 99.9 | 16 | PDB header:hydrolase Chain: B: PDB Molecule:acyl-coenzyme a thioesterase 2, mitochondrial; PDBTitle: crystal structure of human mitochondrial acyl-coa2 thioesterase (acot2)
45 | c3ga7A_ |
| not modelled | 99.9 | 17 | PDB header:hydrolase Chain: A: PDB Molecule:acetyl esterase; PDBTitle: 1.55 angstrom crystal structure of an acetyl esterase from salmonella2 typhimurium
46 | c3bjrA_ |
| not modelled | 99.9 | 15 | PDB header:hydrolase Chain: A: PDB Molecule:putative carboxylesterase; PDBTitle: crystal structure of a putative carboxylesterase (lp_1002) from2 lactobacillus plantarum wcfs1 at 2.09 a resolution
47 | c2h1iA_ |
| not modelled | 99.9 | 17 | PDB header:hydrolase Chain: A: PDB Molecule:carboxylesterase; PDBTitle: crystal structure of the bacillus cereus carboxylesterase
48 | c3d0kA_ |
| not modelled | 99.9 | 16 | PDB header:hydrolase Chain: A: PDB Molecule:putative poly(3-hydroxybutyrate) depolymerase lpqc; PDBTitle: crystal structure of the lpqc, poly(3-hydroxybutyrate) depolymerase2 from bordetella parapertussis
49 | c3og9A_ |
| not modelled | 99.9 | 14 | PDB header:hydrolase Chain: A: PDB Molecule:protein yahd a copper inducible hydrolase; PDBTitle: structure of yahd with malic acid
50 | c2o2gA_ |
| not modelled | 99.9 | 17 | PDB header:hydrolase Chain: A: PDB Molecule:dienelactone hydrolase; PDBTitle: crystal structure of dienelactone hydrolase (yp_324580.1) from2 anabaena variabilis atcc 29413 at 1.92 a resolution
51 | c3ksrA_ |
| not modelled | 99.9 | 17 | PDB header:hydrolase Chain: A: PDB Molecule:putative serine hydrolase; PDBTitle: crystal structure of a putative serine hydrolase (xcc3885) from2 xanthomonas campestris pv. campestris at 2.69 a resolution
52 | d1l7aa_ |
| not modelled | 99.9 | 14 | Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Acetyl xylan esterase-like
53 | c3u0vA_ |
| not modelled | 99.9 | 15 | PDB header:hydrolase Chain: A: PDB Molecule:lysophospholipase-like protein 1; PDBTitle: crystal structure analysis of human lyplal1
54 | c3fnbB_ |
| not modelled | 99.9 | 16 | PDB header:hydrolase Chain: B: PDB Molecule:acylaminoacyl peptidase smu_737; PDBTitle: crystal structure of acylaminoacyl peptidase smu_737 from2 streptococcus mutans ua159
55 | d3b5ea1 |
| not modelled | 99.9 | 16 | Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Carboxylesterase/thioesterase 1
56 | d1lzla_ |
| not modelled | 99.9 | 18 | Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Carboxylesterase
57 | d1jkma_ |
| not modelled | 99.9 | 14 | Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Carboxylesterase
58 | d1fj2a_ |
| not modelled | 99.9 | 18 | Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Carboxylesterase/thioesterase 1
59 | d2jbwa1 |
| not modelled | 99.9 | 16 | Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:2,6-dihydropseudooxynicotine hydrolase-like
60 | c2jbwB_ |
| not modelled | 99.9 | 16 | PDB header:hydrolase Chain: B: PDB Molecule:2,6-dihydroxy-pseudo-oxynicotine hydrolase; PDBTitle: crystal structure of the 2,6-dihydroxy-pseudo-oxynicotine2 hydrolase.
61 | c3f67A_ |
| not modelled | 99.9 | 18 | PDB header:hydrolase Chain: A: PDB Molecule:putative dienelactone hydrolase; PDBTitle: crystal structure of putative dienelactone hydrolase from klebsiella2 pneumoniae subsp. pneumoniae mgh 78578
62 | c2hdwB_ |
| not modelled | 99.9 | 16 | PDB header:hydrolase Chain: B: PDB Molecule:hypothetical protein pa2218; PDBTitle: crystal structure of hypothetical protein pa2218 from pseudomonas2 aeruginosa
63 | c3hxkB_ |
| not modelled | 99.9 | 10 | PDB header:hydrolase Chain: B: PDB Molecule:sugar hydrolase; PDBTitle: crystal structure of a sugar hydrolase (yeeb) from2 lactococcus lactis, northeast structural genomics3 consortium target kr108
64 | d1vlqa_ |
| not modelled | 99.9 | 12 | Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Acetyl xylan esterase-like
65 | c3mveB_ |
| not modelled | 99.9 | 13 | PDB header:lyase Chain: B: PDB Molecule:upf0255 protein vv1_0328; PDBTitle: crystal structure of a novel pyruvate decarboxylase
66 | c2r8bA_ |
| not modelled | 99.9 | 15 | PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein atu2452; PDBTitle: the crystal structure of the protein atu2452 of unknown function from2 agrobacterium tumefaciens str. c58
67 | c2wtmC_ |
| not modelled | 99.9 | 16 | PDB header:hydrolase Chain: C: PDB Molecule:est1e; PDBTitle: est1e from butyrivibrio proteoclasticus
68 | c3cn9B_ |
| not modelled | 99.9 | 14 | PDB header:hydrolase Chain: B: PDB Molecule:carboxylesterase; PDBTitle: crystal structure analysis of the carboxylesterase pa3859 from2 pseudomonas aeruginosa pao1- orthorhombic crystal form
69 | c3d7rB_ |
| not modelled | 99.9 | 11 | PDB header:hydrolase Chain: B: PDB Molecule:esterase; PDBTitle: crystal structure of a putative esterase from staphylococcus aureus
70 | d1ufoa_ |
| not modelled | 99.9 | 16 | Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Hypothetical protein TT1662
71 | d1ju3a2 |
| not modelled | 99.9 | 18 | Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:PepX catalytic domain-like
72 | d2r8ba1 |
| not modelled | 99.9 | 20 | Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Carboxylesterase/thioesterase 1
73 | d1u4na_ |
| not modelled | 99.9 | 17 | Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Carboxylesterase
74 | c2wirB_ |
| not modelled | 99.9 | 17 | PDB header:hydrolase Chain: B: PDB Molecule:alpha/beta hydrolase fold-3 domain protein; PDBTitle: hyperthermophilic esterase from the archeon pyrobaculum2 calidifontis
75 | c2c7bA_ |
| not modelled | 99.9 | 17 | PDB header:hydrolase Chain: A: PDB Molecule:carboxylesterase; PDBTitle: the crystal structure of este1, a new thermophilic and2 thermostable carboxylesterase cloned from a metagenomic3 library
76 | c1l7qA_ |
| not modelled | 99.9 | 18 | PDB header:hydrolase Chain: A: PDB Molecule:cocaine esterase; PDBTitle: ser117ala mutant of bacterial cocaine esterase coce
77 | c3h2iA_ |
| not modelled | 99.9 | 18 | PDB header:hydrolase Chain: A: PDB Molecule:esterase; PDBTitle: crystal structure of n228w mutant of the rice cell wall2 degrading esterase lipa from xanthomonas oryzae
78 | c2qruA_ |
| not modelled | 99.9 | 12 | PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of an alpha/beta hydrolase superfamily protein from2 enterococcus faecalis
79 | d1auoa_ |
| not modelled | 99.9 | 17 | Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Carboxylesterase/thioesterase 1
80 | c3fakA_ |
| not modelled | 99.9 | 16 | PDB header:hydrolase Chain: A: PDB Molecule:esterase/lipase; PDBTitle: structural and functional analysis of a hormone-sensitive2 lipase like este5 from a metagenome library
81 | d1dina_ |
| not modelled | 99.9 | 18 | Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Dienelactone hydrolase
82 | d2fuka1 |
| not modelled | 99.9 | 20 | Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Atu1826-like
83 | c2veoA_ |
| not modelled | 99.9 | 18 | PDB header:hydrolase Chain: A: PDB Molecule:lipase a; PDBTitle: x-ray structure of candida antarctica lipase a in its2 closed state.
84 | c3dnmA_ |
| not modelled | 99.9 | 15 | PDB header:hydrolase Chain: A: PDB Molecule:esterase/lipase; PDBTitle: crystal structure hormone-sensitive lipase from a2 metagenome library
85 | d1jfra_ |
| not modelled | 99.9 | 17 | Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Lipase
86 | d1jjia_ |
| not modelled | 99.9 | 17 | Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Carboxylesterase
87 | d2i3da1 |
| not modelled | 99.9 | 15 | Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Atu1826-like
88 | c2i3dA_ |
| not modelled | 99.9 | 15 | PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical protein atu1826; PDBTitle: crystal structure of protein of unknown function atu1826, a putative2 alpha/beta hydrolase from agrobacterium tumefaciens
89 | c3qh4A_ |
| not modelled | 99.9 | 16 | PDB header:hydrolase Chain: A: PDB Molecule:esterase lipw; PDBTitle: crystal structure of esterase lipw from mycobacterium marinum
90 | c2fx5A_ |
| not modelled | 99.8 | 19 | PDB header:hydrolase Chain: A: PDB Molecule:lipase; PDBTitle: pseudomonas mendocina lipase
91 | c3fcyB_ |
| not modelled | 99.8 | 14 | PDB header:hydrolase Chain: B: PDB Molecule:xylan esterase 1; PDBTitle: crystal structure of acetyl xylan esterase 1 from2 thermoanaerobacterium sp. jw/sl ys485
92 | d1hlga_ |
| not modelled | 99.8 | 14 | Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Gastric lipase
93 | d2b9va2 |
| not modelled | 99.8 | 18 | Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:PepX catalytic domain-like
94 | c3aikB_ |
| not modelled | 99.8 | 15 | PDB header:hydrolase Chain: B: PDB Molecule:303aa long hypothetical esterase; PDBTitle: crystal structure of a hsl-like carboxylesterase from sulfolobus2 tokodaii
95 | c3h04A_ |
| not modelled | 99.8 | 12 | PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: the crystal structure of the protein with unknown function from2 staphylococcus aureus subsp. aureus mu50
96 | c2b9vB_ |
| not modelled | 99.8 | 17 | PDB header:hydrolase Chain: B: PDB Molecule:alpha-amino acid ester hydrolase; PDBTitle: acetobacter turbidans alpha-amino acid ester hydrolase
97 | c1ycdA_ |
| not modelled | 99.8 | 15 | PDB header:structural genomics, unknown function Chain: A: PDB Molecule:hypothetical 27.3 kda protein in aap1-smf2 PDBTitle: crystal structure of yeast fsh1/yhr049w, a member of the2 serine hydrolase family
98 | c3llcA_ |
| not modelled | 99.8 | 20 | PDB header:hydrolase Chain: A: PDB Molecule:putative hydrolase; PDBTitle: crystal structure of putative hydrolase (yp_002548124.1) from2 agrobacterium vitis s4 at 1.80 a resolution
99 | c3ib3A_ |
| not modelled | 99.8 | 12 | PDB header:hydrolase Chain: A: PDB Molecule:coce/nond family hydrolase; PDBTitle: crystal structure of sacol2612 - coce/nond family hydrolase from2 staphylococcus aureus
100 | c3trdA_ |
| not modelled | 99.8 | 15 | PDB header:hydrolase Chain: A: PDB Molecule:alpha/beta hydrolase; PDBTitle: structure of an alpha-beta serine hydrolase homologue from coxiella2 burnetii
101 | d1vkha_ |
| not modelled | 99.8 | 9 | Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Putative serine hydrolase Ydr428c
102 | d2pbla1 |
| not modelled | 99.8 | 15 | Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Carboxylesterase
103 | d1mpxa2 |
| not modelled | 99.8 | 14 | Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:PepX catalytic domain-like
104 | c3qm1A_ |
| not modelled | 99.8 | 17 | PDB header:hydrolase Chain: A: PDB Molecule:cinnamoyl esterase; PDBTitle: crystal structure of the lactobacillus johnsonii cinnamoyl esterase2 lj0536 s106a mutant in complex with ethylferulate, form ii
105 | c3g8yA_ |
| not modelled | 99.8 | 13 | PDB header:hydrolase Chain: A: PDB Molecule:susd/ragb-associated esterase-like protein; PDBTitle: crystal structure of a putative hydrolase (bvu_4111) from bacteroides2 vulgatus atcc 8482 at 1.90 a resolution
106 | d1k8qa_ |
| not modelled | 99.8 | 15 | Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:Gastric lipase
107 | c3jw8A_ |
| not modelled | 99.8 | 18 | PDB header:hydrolase Chain: A: PDB Molecule:mgll protein; PDBTitle: crystal structure of human mono-glyceride lipase
108 | d2d81a1 |
| not modelled | 99.8 | 10 | Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:PHB depolymerase-like
109 | c1mpxB_ |
| not modelled | 99.7 | 15 | PDB header:hydrolase Chain: B: PDB Molecule:alpha-amino acid ester hydrolase; PDBTitle: alpha-amino acid ester hydrolase labeled with selenomethionine
110 | c3hjuB_ |
| not modelled | 99.7 | 19 | PDB header:hydrolase Chain: B: PDB Molecule:monoglyceride lipase; PDBTitle: crystal structure of human monoglyceride lipase
111 | c2qjwA_ |
| not modelled | 99.7 | 18 | PDB header:hydrolase Chain: A: PDB Molecule:uncharacterized protein xcc1541; PDBTitle: crystal structure of a putative hydrolase of the alpha/beta2 superfamily (xcc1541) from xanthomonas campestris pv. campestris at3 1.35 a resolution
112 | c3dyvA_ |
| not modelled | 99.7 | 20 | PDB header:hydrolase Chain: A: PDB Molecule:esterase d; PDBTitle: snapshots of esterase d from lactobacillus rhamnosus:2 insights into a rotation driven catalytic mechanism
113 | d1lnsa3 |
| not modelled | 99.7 | 17 | Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:PepX catalytic domain-like
114 | d2b61a1 |
| not modelled | 99.7 | 15 | Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:O-acetyltransferase
115 | c3nuzF_ |
| not modelled | 99.7 | 14 | PDB header:hydrolase Chain: F: PDB Molecule:putative acetyl xylan esterase; PDBTitle: crystal structure of a putative acetyl xylan esterase (bf1801) from2 bacteroides fragilis nctc 9343 at 2.30 a resolution
116 | c2q0xA_ |
| not modelled | 99.7 | 12 | PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: alpha/beta hydrolase fold protein of unknown function
117 | c2vavL_ |
| not modelled | 99.7 | 12 | PDB header:transferase Chain: L: PDB Molecule:acetyl-coa--deacetylcephalosporin c PDBTitle: crystal structure of deacetylcephalosporin c2 acetyltransferase (dac-soak)
118 | c1cr6A_ |
| not modelled | 99.7 | 14 | PDB header:hydrolase Chain: A: PDB Molecule:epoxide hydrolase; PDBTitle: crystal structure of murine soluble epoxide hydrolase2 complexed with cpu inhibitor
119 | c2y6vB_ |
| not modelled | 99.7 | 15 | PDB header:hydrolase Chain: B: PDB Molecule:peroxisomal membrane protein lpx1; PDBTitle: peroxisomal alpha-beta-hydrolase lpx1 (yor084w) from2 saccharomyces cerevisiae (crystal form i)
120 | d1uxoa_ |
| not modelled | 99.7 | 13 | Fold:alpha/beta-Hydrolases Superfamily:alpha/beta-Hydrolases Family:YdeN-like

Binding site prediction |

Due to computational demand, binding site predictions are not run for batch jobs

If you want to predict binding sites, please manually submit your model of choice to 3DLigandSite

Phyre is for academic use only

Please cite: Protein structure prediction on the web: a case study using the Phyre server
Kelley LA and Sternberg MJE. Nature Protocols 4, 363 - 371 (2009) [pdf] [Import into BibTeX]
If you use the binding site predictions from 3DLigandSite, please also cite:
3DLigandSite: predicting ligand-binding sites using similar structures.
Wass MN, Kelley LA and Sternberg MJ Nucleic Acids Research 38, W469-73 (2010) [PubMed]
© Structural Bioinformatics Group
Imperial College London
Lawrence Kelley, Benjamin Jefferys
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Component software
Template detection: HHpred 1.51
Secondary structure prediction: Psi-pred 2.5
Disorder prediction: Disopred 2.4
Transmembrane prediction: Memsat_SVM
Multi-template modelling and ab initio: Poing 1.0