BLASTP 2.2.22 [Sep-27-2009]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.


Reference for composition-based statistics:
Schaffer, Alejandro A., L. Aravind, Thomas L. Madden,
Sergei Shavirin, John L. Spouge, Yuri I. Wolf,  
Eugene V. Koonin, and Stephen F. Altschul (2001), 
"Improving the accuracy of PSI-BLAST protein database searches with 
composition-based statistics and other refinements",  Nucleic Acids Res. 29:2994-3005.

Query= batch____
         (548 letters)

Database: uniref50.fasta 
           3,077,464 sequences; 1,040,396,356 total letters

Searching..................................................done


Results from round 1


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

UniRef50_P40720 Fumarate hydratase class I, aerobic n=586 Tax=ce...   678   0.0  
UniRef50_Q8I2N6 Fumarate hydratase, putative n=1 Tax=Plasmodium ...   565   e-159
UniRef50_Q4UCY6 Fumarate hydratase class I, putative n=3 Tax=Aco...   558   e-157
UniRef50_Q7RE85 Fumarate hydratase class I, aerobic-related n=2 ...   555   e-156
UniRef50_B3L2U4 Fumarate hydratase, putative n=3 Tax=Plasmodium ...   552   e-155
UniRef50_Q04718 Fumarate hydratase class I, aerobic n=112 Tax=Ba...   489   e-136
UniRef50_A0KKZ8 Fumarate hydratase, class I n=388 Tax=cellular o...   489   e-136
UniRef50_D2M1S7 Hydro-lyase, Fe-S type, tartrate/fumarate subfam...   476   e-133
UniRef50_C8PSZ3 Fumarate hydratase class I, anaerobic n=1 Tax=Tr...   467   e-130
UniRef50_A8AAA8 Fumarase n=10 Tax=Archaea RepID=A8AAA8_IGNH4          460   e-128
UniRef50_B1B7A5 Fumarase n=4 Tax=Bacteria RepID=B1B7A5_CLOBO          343   7e-93
UniRef50_B2TIL9 Fumarate hydratase n=6 Tax=Clostridia RepID=B2TI...   336   1e-90
UniRef50_B1I426 Hydro-lyase, Fe-S type, tartrate/fumarate subfam...   328   5e-88
UniRef50_B4SZG5 Fumarate hydratase n=21 Tax=Salmonella enterica ...   327   6e-88
UniRef50_Q312U0 Fumarase alpha subunit n=1 Tax=Desulfovibrio des...   326   9e-88
UniRef50_Q1LBZ5 Fumarase alpha subunit n=20 Tax=Bacteria RepID=Q...   321   4e-86
UniRef50_B1GZT9 Fumarate hydratase alpha subunit n=1 Tax=uncultu...   321   5e-86
UniRef50_Q469V4 Fumarase alpha subunit n=6 Tax=Archaea RepID=Q46...   321   6e-86
UniRef50_A6Q389 Fumarate/tartrate hydratase, alpha subunit n=9 T...   310   9e-83
UniRef50_A6T6H6 Tartrate dehydratase n=1 Tax=Klebsiella pneumoni...   306   1e-81
UniRef50_Q0RXW8 Fumarate hydratase, class I n=2 Tax=Bacteria Rep...   305   3e-81
UniRef50_A2BJ70 L(+)-tartrate dehydratase class I, alpha subunit...   302   2e-80
UniRef50_Q0W345 Fumarate hydratase (Fumarase), alpha subunit n=1...   301   3e-80
UniRef50_B2KBV3 Hydro-lyase, Fe-S type, tartrate/fumarate subfam...   301   6e-80
UniRef50_B1L7M6 Tartrate dehydratase alpha subunit/Fumarate hydr...   301   6e-80
UniRef50_Q58690 Putative fumarate hydratase subunit alpha n=18 T...   300   1e-79
UniRef50_Q2RG69 Fumarase alpha subunit n=13 Tax=Bacteria RepID=Q...   299   1e-79
UniRef50_A2SQV2 Fumarase alpha subunit n=2 Tax=Methanomicrobiale...   298   3e-79
UniRef50_A9HYF3 Fumarate hydratase alpha subunit n=3 Tax=Proteob...   297   8e-79
UniRef50_B8GKW0 Hydro-lyase, Fe-S type, tartrate/fumarate subfam...   293   1e-77
UniRef50_A4YFS7 Fumarase alpha subunit n=1 Tax=Metallosphaera se...   293   2e-77
UniRef50_A4WJ46 Fumarase alpha subunit n=2 Tax=Thermoproteaceae ...   289   2e-76
UniRef50_A0B6L8 Fumarase alpha subunit n=1 Tax=Methanosaeta ther...   287   6e-76
UniRef50_B0VIF1 Tartrate dehydratase alpha subunit (TtdA)/Fumara...   287   8e-76
UniRef50_B5YEU7 Fumarate hydratase n=1 Tax=Dictyoglomus thermoph...   279   2e-73
UniRef50_B0EPH7 Serine acetyltransferase, putative n=10 Tax=cell...   274   5e-72
UniRef50_C9KL20 L(+)-tartrate dehydratase subunit alpha n=1 Tax=...   272   2e-71
UniRef50_A9BJT0 Hydro-lyase, Fe-S type, tartrate/fumarate subfam...   270   8e-71
UniRef50_A1WMD3 Fumarase alpha subunit n=1 Tax=Verminephrobacter...   268   3e-70
UniRef50_A8S1R3 Putative uncharacterized protein n=1 Tax=Clostri...   267   6e-70
UniRef50_Q0TD45 L(+)-tartrate dehydratase subunit alpha n=126 Ta...   265   4e-69
UniRef50_C7IGU6 Hydro-lyase, Fe-S type, tartrate/fumarate subfam...   262   2e-68
UniRef50_A7HKF1 Hydro-lyase, Fe-S type, tartrate/fumarate subfam...   256   1e-66
UniRef50_Q8U062 Possible fumarate hydratase (Fumarase) alpha sub...   255   3e-66
UniRef50_C8WG72 Hydro-lyase, Fe-S type, tartrate/fumarate subfam...   251   7e-65
UniRef50_Q3IXH2 Fumarase alpha subunit n=14 Tax=Proteobacteria R...   245   3e-63
UniRef50_A6TTM2 Hydro-lyase, Fe-S type, tartrate/fumarate subfam...   245   3e-63
UniRef50_Q2RG70 Hydro-lyases, Fe-S type, tartrate/fumarate subfa...   245   4e-63
UniRef50_C1SNL0 Hydro-lyase, Fe-S type, tartrate/fumarate subfam...   244   9e-63
UniRef50_C3PJK7 Tartrate dehydratase n=18 Tax=Bacteria RepID=C3P...   239   2e-61
UniRef50_B8I5L5 Hydro-lyase, Fe-S type, tartrate/fumarate subfam...   237   5e-61
UniRef50_Q58034 Putative fumarate hydratase subunit beta n=13 Ta...   236   2e-60
UniRef50_D1SM64 Hydro-lyase, Fe-S type, tartrate/fumarate subfam...   234   7e-60
UniRef50_A4XHH2 Hydro-lyase, Fe-S type, tartrate/fumarate subfam...   234   8e-60
UniRef50_C4GCC8 Putative uncharacterized protein n=1 Tax=Shuttle...   233   2e-59
UniRef50_Q469V5 Fumarase beta subunit n=10 Tax=Archaea RepID=Q46...   225   2e-57
UniRef50_A1RT45 Fumarase beta subunit n=8 Tax=Thermoprotei RepID...   225   3e-57
UniRef50_UPI0001C35B8B hydro-lyase, Fe-S type, tartrate/fumarate...   222   2e-56
UniRef50_D1BP97 Hydro-lyase, Fe-S type, tartrate/fumarate subfam...   222   3e-56
UniRef50_Q1LBZ6 Hydro-lyases, Fe-S type, tartrate/fumarate subfa...   220   1e-55
UniRef50_Q0W346 Fumarate hydratase (Fumarase), beta subunit n=1 ...   220   1e-55
UniRef50_B1L7M7 Tartrate dehydratase beta subunit/Fumarate hydra...   219   2e-55
UniRef50_B1I607 Hydro-lyase, Fe-S type, tartrate/fumarate subfam...   218   5e-55
UniRef50_B2TIM0 Fumarate hydratase, class I n=18 Tax=Bacteria Re...   217   7e-55
UniRef50_C8QYN2 Hydro-lyase, Fe-S type, tartrate/fumarate subfam...   217   1e-54
UniRef50_B5YEU6 Fumarate hydratase, beta subunit n=2 Tax=Dictyog...   216   1e-54
UniRef50_C9RML3 Hydro-lyase, Fe-S type, tartrate/fumarate subfam...   216   2e-54
UniRef50_Q30V65 Hydro-lyases, Fe-S type, tartrate/fumarate subfa...   215   4e-54
UniRef50_Q3YXI1 L(+)-tartrate dehydratase subunit beta n=108 Tax...   213   2e-53
UniRef50_D0TAD5 Fumarate hydratase n=1 Tax=Bacteroides sp. 2_1_3...   212   3e-53
UniRef50_D2RKV4 Hydro-lyase, Fe-S type, tartrate/fumarate subfam...   212   3e-53
UniRef50_C0CW47 Putative uncharacterized protein n=1 Tax=Clostri...   212   3e-53
UniRef50_C7IGU5 Hydro-lyase, Fe-S type, tartrate/fumarate subfam...   211   6e-53
UniRef50_C1SNL1 Hydro-lyase family enzyme, Fe-S type, tartrate/f...   210   1e-52
UniRef50_A5UKC4 Fumarate hydratase, alpha subunit n=4 Tax=Methan...   209   2e-52
UniRef50_B2KBV4 Hydro-lyase, Fe-S type, tartrate/fumarate subfam...   208   4e-52
UniRef50_O27932 Fumarate hydratase, class I related protein n=5 ...   207   1e-51
UniRef50_B5F039 Hydro-lyase, Fe-S type, tartrate/fumarate subfam...   207   1e-51
UniRef50_C9KL19 L(+)-tartrate dehydratase subunit beta n=1 Tax=M...   204   5e-51
UniRef50_C8WG73 Fe-S type hydro-lyase tartrate/fumarate beta reg...   204   6e-51
UniRef50_Q0RXW9 L(+)-tartrate dehydratase beta subunit n=2 Tax=B...   203   2e-50
UniRef50_B0VIF2 Tartrate dehydratase beta subunit (TtdB)/fumarat...   202   2e-50
UniRef50_A9BJS9 Hydro-lyase, Fe-S type, tartrate/fumarate subfam...   201   7e-50
UniRef50_C3PJK6 L-tartrate dehydratase n=19 Tax=Bacteria RepID=C...   200   1e-49
UniRef50_A4YFS6 Hydro-lyase, Fe-S type, tartrate/fumarate subfam...   197   1e-48
UniRef50_A9HYF7 L-tartrate dehydratase, subunit B n=3 Tax=Proteo...   196   2e-48
UniRef50_O27044 Fumarate hydratase, class I related protein n=2 ...   195   3e-48
UniRef50_A7I689 Hydro-lyase, Fe-S type, tartrate/fumarate subfam...   194   7e-48
UniRef50_A1HQH2 Fe-S type hydro-lyases tartrate/fumarate alpha r...   192   3e-47
UniRef50_A7HKF0 Fe-S type hydro-lyase tartrate/fumarate beta reg...   186   2e-45
UniRef50_B4UMA9 Fe-S type hydro-lyase tartrate/fumarate beta reg...   185   5e-45
UniRef50_B8GKV9 Hydro-lyase, Fe-S type, tartrate/fumarate subfam...   182   3e-44
UniRef50_UPI000190D92B fumarate hydratase class I, anaerobic n=1...   175   3e-42
UniRef50_B0NH77 Putative uncharacterized protein n=1 Tax=Clostri...   167   7e-40
UniRef50_Q28K74 Fe-S type hydro-lyases tartrate/fumarate beta pr...   167   1e-39
UniRef50_UPI0001C41F68 fumarate hydratase FumA4 n=1 Tax=Methanob...   165   3e-39
UniRef50_B5Y8W5 Putative uncharacterized protein n=1 Tax=Coproth...   165   3e-39
UniRef50_A1WMD4 Fumarate hydratase class I beta subunit n=1 Tax=...   157   9e-37
UniRef50_C9RML5 Fe-S type hydro-lyase tartrate/fumarate beta reg...   157   2e-36
UniRef50_A5ULQ6 Fumarate hydratase, FumA n=3 Tax=Methanobrevibac...   155   4e-36
UniRef50_UPI0001C35B8A Fe-S type hydro-lyase tartrate/fumarate b...   147   1e-33
UniRef50_B9Z0L3 Tartrate dehydratase alpha subunit/Fumarate hydr...   145   6e-33
UniRef50_C8T983 Fumarate hydratase class I n=3 Tax=Enterobacteri...   135   4e-30
UniRef50_B5Y8W4 Hydro-lyase, Fe-S type, tartrate/fumarate subfam...   125   7e-27
UniRef50_O27187 Fumarate hydratase, class I n=1 Tax=Methanotherm...   118   8e-25
UniRef50_A8F6X8 Putative uncharacterized protein n=1 Tax=Thermot...   116   3e-24
UniRef50_UPI000190C03B fumarase A (fumarate hydratase class I), ...    48   7e-04

>UniRef50_P40720 Fumarate hydratase class I, aerobic n=586 Tax=cellular organisms
           RepID=FUMA_SALTY
          Length = 580

 Score =  678 bits (1749), Expect = 0.0,   Method: Composition-based stats.
 Identities = 484/543 (89%), Positives = 511/543 (94%)

Query: 1   MSNKPFIYQAPFPMGKDNTEYYLLTSDYVSVADFDGETILKVEPEALTLLAQQAFHDASF 60
           MSNKPF YQ PFP+ KD+TEYYLLTS++VSVA+F+G+ ILKV PEALTLLA+QAFHDASF
Sbjct: 1   MSNKPFFYQDPFPLKKDDTEYYLLTSEHVSVAEFEGQEILKVAPEALTLLARQAFHDASF 60

Query: 61  MLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAKGVLPTCQDTGTAIIVGKKGQR 120
           MLRPAHQ+QVA IL DP+ASENDKYVALQFLRNS+IAAKGVLPTCQDTGTAIIVGKKGQR
Sbjct: 61  MLRPAHQQQVADILRDPQASENDKYVALQFLRNSDIAAKGVLPTCQDTGTAIIVGKKGQR 120

Query: 121 VWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEVNTGTNLPAQIDLYAVDGDEYKF 180
           VWTGGGDE  L++GVYNTYIEDNLRYSQNAALDMYKEVNTGTNLPAQIDLY+VDGDEYKF
Sbjct: 121 VWTGGGDEAALARGVYNTYIEDNLRYSQNAALDMYKEVNTGTNLPAQIDLYSVDGDEYKF 180

Query: 181 LCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRTLGTAACPPYHIAFVIGGTSAET 240
           LC+AKGGGSANKTYLYQETKALLTPGKLKN+LV+KMRTLGTAACPPYHIAFVIGGTSAE 
Sbjct: 181 LCIAKGGGSANKTYLYQETKALLTPGKLKNYLVDKMRTLGTAACPPYHIAFVIGGTSAEA 240

Query: 241 NLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLEEAQKLGLGAQFGGKYFAHDIRV 300
           NLKTVKLASA YYD LPTEGNEHGQAFRD++LE+ELL EAQ LGLGAQFGGKYFAHDIRV
Sbjct: 241 NLKTVKLASAKYYDALPTEGNEHGQAFRDIELEKELLLEAQNLGLGAQFGGKYFAHDIRV 300

Query: 301 IRLPRHGASCPVGMGVSCSADRNIKAKINREGIWIEKLEHNPGQYIPQELRQAGEGEAVK 360
           IRLPRHGASCPVGMGVSCSADRNIKAKINR+GIWIEKLE NPG+YIP+ LRQAGEGEAV+
Sbjct: 301 IRLPRHGASCPVGMGVSCSADRNIKAKINRDGIWIEKLERNPGKYIPEALRQAGEGEAVR 360

Query: 361 VDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHPIY 420
           VDLNRPM EIL QLSQYPVSTRLSL GTIIVGRDIAHAKLKE +D G+ LPQYIKDHPIY
Sbjct: 361 VDLNRPMSEILQQLSQYPVSTRLSLNGTIIVGRDIAHAKLKERMDRGEGLPQYIKDHPIY 420

Query: 421 YAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHGGF 480
           YAGPAKTP GY SGSLGPTTAGRMDSYVD LQS GGSMIMLAKGNRSQQVTDAC KHGGF
Sbjct: 421 YAGPAKTPEGYASGSLGPTTAGRMDSYVDQLQSQGGSMIMLAKGNRSQQVTDACKKHGGF 480

Query: 481 YLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQIVN 540
           YLGSIGGPAAVLAQ SIK LECV YPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQI +
Sbjct: 481 YLGSIGGPAAVLAQGSIKRLECVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQIQS 540

Query: 541 KQC 543
            QC
Sbjct: 541 SQC 543


>UniRef50_Q8I2N6 Fumarate hydratase, putative n=1 Tax=Plasmodium falciparum 3D7
           RepID=Q8I2N6_PLAF7
          Length = 681

 Score =  565 bits (1457), Expect = e-159,   Method: Composition-based stats.
 Identities = 267/584 (45%), Positives = 373/584 (63%), Gaps = 59/584 (10%)

Query: 16  KDNTEYYLLTSDYVSVADFDGETILKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILH 75
             N + Y+   +   +     +  + + P  LT L + AF +  F L   H KQ+  IL 
Sbjct: 99  HGNIKEYIYNENKKLLYKNYEKEYIHIPPFVLTKLCEYAFKEILFFLNKKHLKQLQHILQ 158

Query: 76  DPEASENDKYVALQFLRNSEIAAKGVLPTCQDTGTAIIVGKKGQRVWTGGGDEETLSKGV 135
           D E+S+NDKYVA+  ++N+ I+++  LP CQDTGTAII+GKK + + T     + L+ GV
Sbjct: 159 DKESSKNDKYVAMTLIKNAIISSEQKLPGCQDTGTAIILGKKDEDILTTYE-HKYLTLGV 217

Query: 136 YNTYIEDNLRYSQNAALDMYKEV------------------------------------- 158
           YN Y  +N RYSQ + L+M+ EV                                     
Sbjct: 218 YNAYKYNNFRYSQLSPLNMFNEVNTKNNLPCQIEIYTNIKKEKLHEVQQNEYPNHMKDIQ 277

Query: 159 ---NTGTN---LPAQID-------------LYAVDGDEYKFLCVAKGGGSANKTYLYQET 199
              N   N      QID              +  DG +Y+ + +AKGGGSANKT+L+Q+T
Sbjct: 278 NNNNVKHNKDITTRQIDSKENQKSTKKQNVDFLYDGPKYELIFIAKGGGSANKTFLFQQT 337

Query: 200 KALLTPGKLKNFLVEKMRTLGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTE 259
           K++L    L NFL++K++ +GT+ACPPYH+A VIGG SAE NLK VKLAS  Y D L TE
Sbjct: 338 KSILNEENLYNFLLDKIKEIGTSACPPYHLAIVIGGLSAEMNLKMVKLASCRYLDNLKTE 397

Query: 260 GNEHGQAFRDVQLEQELLEEAQKLGLGAQFGGKYFAHDIRVIRLPRHGASCPVGMGVSCS 319
           G  +G+AFRD++ E+ +L++AQ LG+GAQFGGKYF HD+RVIRLPRH ASCP+G+GVSCS
Sbjct: 398 GGIYGKAFRDLESEKIILQKAQSLGIGAQFGGKYFVHDVRVIRLPRHSASCPIGIGVSCS 457

Query: 320 ADRNIKAKINREGIWIEKLEHNPGQYIPQ-ELRQAGEGEAVKVDLNRPMKEILAQLSQYP 378
           ADR IK  IN+ G++++ LEH P +Y+P+   +   +  AVK+DLN+ M++ L  LS+YP
Sbjct: 458 ADRQIKCLINKNGVFMQMLEHEPIKYLPEITFKDLNQENAVKIDLNQNMEQTLKTLSKYP 517

Query: 379 VSTRLSLTGTIIVGRDIAHAKLKE-LIDAGKELPQYIKDHPIYYAGPAKTPAGYPSGSLG 437
            ST + LTG ++V RD AH K+ +  I+    +P+Y K +PIYYAGPAKTP  Y SGS G
Sbjct: 518 TSTLVLLTGKLVVARDSAHKKIVDQFINDNVPIPEYFKKYPIYYAGPAKTPDNYASGSFG 577

Query: 438 PTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHGGFYLGSIGGPAAVLAQQSI 497
           PTTAGRMD+Y ++L  +  S+I LAKGNRS  V +AC K+ GFYLGSIGGP A+LA+ +I
Sbjct: 578 PTTAGRMDAYAEVLMKNNASLISLAKGNRSAVVRNACKKYNGFYLGSIGGPGAILAKNNI 637

Query: 498 KHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQIVNK 541
           K+++ + + ++GMEA+  I+V DFPAFI++D+KGNDF+ + +  
Sbjct: 638 KNVQVIDFKDMGMEAVHLIDVVDFPAFIVIDNKGNDFYNKWLPS 681


>UniRef50_Q4UCY6 Fumarate hydratase class I, putative n=3 Tax=Aconoidasida
           RepID=Q4UCY6_THEAN
          Length = 622

 Score =  558 bits (1437), Expect = e-157,   Method: Composition-based stats.
 Identities = 285/539 (52%), Positives = 379/539 (70%), Gaps = 24/539 (4%)

Query: 23  LLTSDYVSVADFDGETI--LKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEAS 80
           LL  +  ++   DG  +  L V PE LT L   AF +    LR  H  Q+  +  DPE+S
Sbjct: 86  LLRLNESNLVKSDGTNLKFLNVPPEVLTQLTSLAFTEIMHFLRTEHLAQLRKVFDDPESS 145

Query: 81  ENDKYVALQFLRNSEIAAKGV----------LPTCQDTGTAIIVGKKGQRVWTGGGDEET 130
           +ND++V++Q L+N+ I+A             LP CQDTGTAI++GK+G  +     D  +
Sbjct: 146 DNDRFVSMQLLKNACISAGKYFFLLILLYRVLPGCQDTGTAIVIGKRGNNI-FSENDTNS 204

Query: 131 LSKGVYNTYIEDNLRYSQNAALDMYKEVNTGTNLPAQIDLYAVDGDEYKFLCVAKGGGSA 190
           ++KG+YN YI  N RYSQ +AL+MY+EVNT  NLPAQ++LY+ DG +Y+FL +AKGGGSA
Sbjct: 205 ITKGIYNCYINKNFRYSQMSALNMYEEVNTRCNLPAQVELYSQDGIDYEFLFIAKGGGSA 264

Query: 191 NKTYLYQETKALLTPGKLKNFLVEKMRTLGTAACPPYHIAFVIGGTSAETNLKTVKLASA 250
           NKT+LYQ+TK++L    L  FL+E+++T+GT+ACPPYH+A VIGG SAE  LKTVKLAS 
Sbjct: 265 NKTFLYQQTKSILNEKMLIEFLMEQIKTIGTSACPPYHLAIVIGGLSAEMTLKTVKLASC 324

Query: 251 HYYDELPTEGNEHGQAFRDVQLEQELLEEAQKLGLGAQFGGKYFAHDIRVIRLPRHGASC 310
            Y D LPTEGN  G AFRD+  EQ +L++ +++G+GAQFGGKYF HD+R+IRLPRHGASC
Sbjct: 325 KYLDNLPTEGNLFGNAFRDLDFEQTILQKTREIGIGAQFGGKYFCHDVRIIRLPRHGASC 384

Query: 311 PVGMGVSCSADRNIKAKINREG----------IWIEKLEHNPGQYIPQELRQAGEGEAVK 360
           P+G+GVSCSADR + AKIN  G          +++E+LEH+P Q++P  +      + + 
Sbjct: 385 PIGIGVSCSADRQVLAKINPTGGLLIIFQYFLVYLEELEHDPAQFLPT-IGHVPNTKEIN 443

Query: 361 VDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHPIY 420
           +DL   M+++L Q+ ++PV TRL L G +IV RDIAHA + E  D   +LP YIKD PIY
Sbjct: 444 IDLTIGMEKVLEQVRKFPVKTRLLLNGPLIVARDIAHAMIVEQFDKTGQLPNYIKDFPIY 503

Query: 421 YAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHGGF 480
           YAGPAK P GY SGS GPTTAGRMDSY   L  HG S+I LAKGNRS+   +AC K GG 
Sbjct: 504 YAGPAKRPDGYVSGSFGPTTAGRMDSYASKLMEHGASLITLAKGNRSRSFVNACKKFGGV 563

Query: 481 YLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQIV 539
           YLGS+GGPAA++A+  I+ +E V +P+LGMEA+ KI V++FPAF++VD KGNDF+ Q  
Sbjct: 564 YLGSVGGPAALIAEDCIESVEVVDFPQLGMEAVHKILVKNFPAFVVVDSKGNDFYSQWS 622


>UniRef50_Q7RE85 Fumarate hydratase class I, aerobic-related n=2 Tax=Plasmodium
           (Vinckeia) RepID=Q7RE85_PLAYO
          Length = 671

 Score =  555 bits (1431), Expect = e-156,   Method: Composition-based stats.
 Identities = 265/572 (46%), Positives = 370/572 (64%), Gaps = 39/572 (6%)

Query: 8   YQAPFPMGKDNTEYYLLTSDYVSVADFDGETILKVEPEALTLLAQQAFHDASFMLRPAHQ 67
           Y+       DN    +  +          +  + V P  LT L + A  +  F L   H 
Sbjct: 101 YEDENEFFDDNGNLKIKNNYEKESKKNVIKEYIHVPPFVLTKLCEYALKEILFFLNKNHL 160

Query: 68  KQVAAILHDPEASENDKYVALQFLRNSEIAAKGVLPTCQDTGTAIIVGKKGQRVWTGGGD 127
           KQ+  IL D  +SENDK+VA+  ++N+ I++   LP CQDTGTAII+GKK + +      
Sbjct: 161 KQLQNILIDKNSSENDKFVAMTLIKNAIISSNQNLPGCQDTGTAIILGKKDEEILVTYE- 219

Query: 128 EETLSKGVYNTYIEDNLRYSQNAALDMYKEVNTGTNLPAQIDLY------------AVDG 175
            + ++ GVYN Y ++N RYSQ + ++M+ E+NT  NLP QI++Y                
Sbjct: 220 HKYITLGVYNAYKKNNFRYSQLSPINMFDEINTKNNLPCQIEIYSNIKKKENLNDKIKKD 279

Query: 176 DEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRTLGTAACPPYHIAFVIGG 235
            +Y+   +AKGGGSANKT+L+Q+TK++L   K  +FL++K++ +GT+ACPPYH+A VIGG
Sbjct: 280 PKYELTFIAKGGGSANKTFLFQQTKSILNKDKXYDFLLDKIKEIGTSACPPYHLAIVIGG 339

Query: 236 TSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLEEAQKLGLGAQFGGKYFA 295
            S E NLKTVKLAS  Y D+LP EG  +G+AFRD++ E+ +L+++Q L +GAQFGGKYF 
Sbjct: 340 LSPEMNLKTVKLASCRYLDDLPKEGGIYGKAFRDLESEKIILDKSQNLXIGAQFGGKYFV 399

Query: 296 HDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINREGIWIEKLEHNPGQYIPQ------- 348
           HD+RVIRLPRH ASCP+ + VSCSADR IK+ IN+ G++IE LEH+P +Y+P+       
Sbjct: 400 HDVRVIRLPRHSASCPIXIXVSCSADRQIKSVINKNGVFIEDLEHDPIKYLPEVTYDNLK 459

Query: 349 ------------------ELRQAGEGEAVKVDLNRPMKEILAQLSQYPVSTRLSLTGTII 390
                               ++  +   V +DLN+P++ IL  +S YPVST L LTG +I
Sbjct: 460 SGKFRKTEKSEKSENFESGEKKCEQNNGVAIDLNQPIENILKIISNYPVSTLLILTGKLI 519

Query: 391 VGRDIAHAKLKE-LIDAGKELPQYIKDHPIYYAGPAKTPAGYPSGSLGPTTAGRMDSYVD 449
           V RD AH K+ +  I+    +P Y K HPIYYAGPAKTP  Y SGS GPTTAGRMD+Y +
Sbjct: 520 VARDTAHKKIVDNFINKNIPIPDYFKKHPIYYAGPAKTPYNYASGSFGPTTAGRMDAYAE 579

Query: 450 LLQSHGGSMIMLAKGNRSQQVTDACHKHGGFYLGSIGGPAAVLAQQSIKHLECVAYPELG 509
           +L  +  S+I LAKGNRS  V +AC K+ GFYLGSIGGP A+LA+ +I++++ + + ELG
Sbjct: 580 ILMKNNASLISLAKGNRSIVVKNACKKYNGFYLGSIGGPGAILAKNNIRNVKVIDFHELG 639

Query: 510 MEAIWKIEVEDFPAFILVDDKGNDFFQQIVNK 541
           MEA+  IEV DFPAFI++D+KGNDF+ + +  
Sbjct: 640 MEAVHLIEVVDFPAFIIIDNKGNDFYNKWIPS 671


>UniRef50_B3L2U4 Fumarate hydratase, putative n=3 Tax=Plasmodium RepID=B3L2U4_PLAKH
          Length = 673

 Score =  552 bits (1422), Expect = e-155,   Method: Composition-based stats.
 Identities = 276/556 (49%), Positives = 370/556 (66%), Gaps = 53/556 (9%)

Query: 37  ETILKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEI 96
           +  + + P  LT L + AF +  F L   H KQ++ IL D E+S+NDKYVA+  ++N+ I
Sbjct: 118 KEYIHIPPFVLTKLCEYAFREILFFLNKKHLKQLSNILKDGESSKNDKYVAMTLIKNAVI 177

Query: 97  AAKGVLPTCQDTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYK 156
           +A+  LP CQDTGTAII+GKK + + T     + L+ GVYN Y  +N RYSQ + L M+ 
Sbjct: 178 SAEQNLPGCQDTGTAIILGKKDEEILTTYE-HKYLNLGVYNAYRNNNFRYSQLSPLSMFS 236

Query: 157 EVNTGTNLPAQIDLY--------------------------AVDGDEYKFLCVAKGGGSA 190
           E NT  NLP QI++Y                               +Y+ + +AKGGGSA
Sbjct: 237 EENTKNNLPCQIEIYSSVRGAKAHGVKTPPGVQLSASSTAPIDSSPKYELIFIAKGGGSA 296

Query: 191 NKTYLYQETKALLTPGKLKNFLVEKMRTLGTAACPPYHIAFVIGGTSAETNLKTVKLASA 250
           NKT+L+Q+TK++L   KL +FL+EK++ +GT+ACPPYH+A VIGG SAE NLK VKLAS 
Sbjct: 297 NKTFLFQQTKSILNEDKLYDFLLEKIKEIGTSACPPYHLAVVIGGLSAEMNLKVVKLASC 356

Query: 251 HYYDELPTEGNEHGQAFRDVQLEQELLEEAQKLGLGAQFGGKYFAHDIRVIRLPRHGASC 310
            Y D L  EG  +G+AFRD + E+ +LE+AQ LG+GAQFGGKYF HD+RVIRLPRH ASC
Sbjct: 357 RYLDNLKKEGGGYGKAFRDTKSEEIILEKAQALGIGAQFGGKYFVHDVRVIRLPRHSASC 416

Query: 311 PVGMGVSCSADRNIKAKINREGIWIEKLEHNPGQYIPQ----ELRQA------------- 353
           P+G+GVSCSADR IK  INREG+++E LEH+P +Y+P+    +L+Q              
Sbjct: 417 PIGIGVSCSADRQIKCLINREGVFMEALEHDPIKYLPEITYNDLKQIGGVATRTGGDDHA 476

Query: 354 --------GEGEAVKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLK-ELI 404
                        V ++LN+PM+ IL  LS++PVST L L+G +IV RD AH ++  + +
Sbjct: 477 KNETGEGLPGEGGVPINLNQPMESILKCLSEHPVSTLLLLSGKLIVARDTAHKRIVDDFV 536

Query: 405 DAGKELPQYIKDHPIYYAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKG 464
             G  +P+Y K  PIYYAGPAKTP  Y SGS GPTTAGRMD+Y ++L  +G S+I LAKG
Sbjct: 537 MRGIPIPEYFKKFPIYYAGPAKTPDNYASGSFGPTTAGRMDAYAEVLMKNGASLISLAKG 596

Query: 465 NRSQQVTDACHKHGGFYLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAF 524
           NRS  V  AC K+ GFYLGSIGGP A+LA+++IK +E + + ELGMEA+  I+V DFPAF
Sbjct: 597 NRSSVVRSACKKYHGFYLGSIGGPGAILAKKNIKKVEVIDFAELGMEAVHLIDVVDFPAF 656

Query: 525 ILVDDKGNDFFQQIVN 540
           I++DDKGNDF+ + + 
Sbjct: 657 IVIDDKGNDFYNKWIP 672


>UniRef50_Q04718 Fumarate hydratase class I, aerobic n=112 Tax=Bacteria
           RepID=FUMA_BACST
          Length = 514

 Score =  489 bits (1260), Expect = e-136,   Method: Composition-based stats.
 Identities = 125/526 (23%), Positives = 198/526 (37%), Gaps = 42/526 (7%)

Query: 45  EALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAKGVLPT 104
           E L     Q   + S  L    ++ +        A             N ++A + V P 
Sbjct: 2   EKLYESMYQLIVETSTKLPKDVRRAILKAKQRENAGTRAAMSLATITENIKMADENVSPI 61

Query: 105 CQDTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEVNTGTNL 164
           CQDTG      K    +      +ET+ K +     +  LR +     D     N+G NL
Sbjct: 62  CQDTGLPTFKIKVPVGI-NQIQIKETIKKAIAQATKDGKLRPNSV---DSLTGENSGDNL 117

Query: 165 P---AQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQET---KALLTPGK----LKNFLVE 214
                 +     + D      + KGGG  NK   Y      + L   G+    ++  ++ 
Sbjct: 118 GEGLPVVKFEQWEKDYMDVRLILKGGGCENKNIQYSLPCELEGLGRAGRDLDGIRKCILH 177

Query: 215 KMRTLGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQ 274
            +       C    I   IGG           LA    + E+    ++        QLE+
Sbjct: 178 AVYQAQGQGCSAGFIGVGIGGD----RSAGYDLAKEQLFREV----DDVNPNEELRQLEE 229

Query: 275 ELLEEAQKLGLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINREGI 333
            ++E A KLG+G   FGG+      +V  + R  AS  V +  +C A R +   I+    
Sbjct: 230 YIMENANKLGIGTMGFGGETTLLGCKVGAMHRIPASFFVSVAYNCWAFRRLGVHIDPNTG 289

Query: 334 WIEKLEHNPGQYIPQELRQAGEG-------EAVKVDLNRPMKEILAQLSQYPVSTRLSLT 386
            I K  +  G+ +  +   A E        E   + L  P+ E   Q+ +  V   + + 
Sbjct: 290 EIIKWLYQDGEDVDFQENAAQEEHLASTDSERRVITLQAPITE--EQIRELKVGDVVRIN 347

Query: 387 GTIIVGRDIAHAKLKELIDAGKELPQYIKDHPIYYAGPAKTPA---GYPSGSLGPTTAGR 443
           G I  GRD  H  L +      + P  +    IY+ GP         +   + GPTT+ R
Sbjct: 348 GIIYTGRDAIHKYLMDH-----DAPVDLNGQIIYHCGPVMLKDENGNWEVKAAGPTTSIR 402

Query: 444 MDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHGGFYLGSIGGPAAVLAQQSIKHLECV 503
            + Y   +    G   ++ KG   Q+   A  +HGG YL +IGG A   A   I+ +E V
Sbjct: 403 EEPYQGDIMKKFGIRAVMGKGGMGQKTLQALKEHGGVYLNAIGGAAQYYA-DCIEAVEGV 461

Query: 504 AYPELG-MEAIWKIEVEDFPAFILVDDKGNDFFQQIVNKQCANCTK 548
              E G  EA+W + V+DF A + +D  GN   + I        ++
Sbjct: 462 DLLEFGIPEAMWHLRVKDFTAVVTMDSHGNSLHEDIEKSSLEKLSQ 507


>UniRef50_A0KKZ8 Fumarate hydratase, class I n=388 Tax=cellular organisms
           RepID=A0KKZ8_AERHH
          Length = 598

 Score =  489 bits (1259), Expect = e-136,   Method: Composition-based stats.
 Identities = 149/527 (28%), Positives = 244/527 (46%), Gaps = 31/527 (5%)

Query: 33  DFDGETILKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLR 92
               + +  ++ +        A    S+   P    Q A   +D E +   K    Q L 
Sbjct: 86  RTSEDDMSIIKKQDFIDSIADALQYISYY-HPLDFVQAAKAAYDREINPAAKDALAQILI 144

Query: 93  NSEIAAKGVLPTCQDTGTAIIVGKKGQRVWTGGGD--EETLSKGVYNTYIE--DNLRYSQ 148
           NS ++A+G  P CQDTG      K G +V        +E + +G    Y    + LR S 
Sbjct: 145 NSRMSAEGHRPLCQDTGIVTCFVKIGMQVQWDSDMTVQEMVDEGTRRAYTNPDNPLRASV 204

Query: 149 NAALDMYKEVNTGTNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKL 208
             A       NT  N PA + +  + GD+ +    AKGGGS NK+ +     +      +
Sbjct: 205 L-ADPAGSRKNTKDNAPAVVHIDMIPGDKVEVSIAAKGGGSENKSKMVMLNPSD----DV 259

Query: 209 KNFLVEKMRTLGTAACPPYHIAFVIGGTSAETNLKTVKLASAHY-YDELPTEGNEHGQAF 267
             ++++ + T+G   CPP  +   IGGT+ +  +   +    H    EL   G +  +  
Sbjct: 260 VEWVLKTVPTMGAGWCPPGMLGIGIGGTAEKAAVLAKEALMEHIDIQELIARGPQTTEE- 318

Query: 268 RDVQLEQELLEEAQKLGLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKA 326
              +L  EL ++  KLG+GAQ  GG     D++V   P H AS PV M  +C+A R++  
Sbjct: 319 ---KLRVELYDKVNKLGIGAQGLGGLTTVLDVKVKSAPTHAASKPVVMIPNCAATRHVHF 375

Query: 327 KINREG---IWIEKLEHNPGQYIPQELRQAGEGEAVKVDLNRPMKEILAQLSQYPVSTRL 383
           +++  G   +   KLE  P      E+ ++  G   +V+++   K   A+L+ +     +
Sbjct: 376 ELDGSGPAELTPPKLEDWP------EITRSAGGNVRRVNVDGITK---AELASWKSGDTV 426

Query: 384 SLTGTIIVGRDIAHAKLKELIDAGKELP--QYIKDHPIYYAGPAKTPAGYPSGSLGPTTA 441
            L+G I+ GRD AH ++ +++  G+ LP      +  IYY GP         G  GPTT+
Sbjct: 427 LLSGKILTGRDAAHKRIADMLKKGEGLPEGVDFTNRFIYYVGPVDAVRDEVVGPAGPTTS 486

Query: 442 GRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHGGFYLGSIGGPAAVLAQQSIKHLE 501
            RMD + D++    G + M+ K  R  +  ++  +H   YL ++GG AA L  ++IK   
Sbjct: 487 TRMDKFTDMMLGETGLIGMIGKSERGLKTVESIKQHQAVYLMAVGG-AAYLVAKAIKKAR 545

Query: 502 CVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQIVNKQCANCTK 548
            VA+ +LGMEAI++ EVED P  + VD +GN+  +       A   +
Sbjct: 546 VVAFADLGMEAIYEFEVEDMPVTVAVDSQGNNIHETGPAYWSAKIAE 592


>UniRef50_D2M1S7 Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit
           n=2 Tax=Bacillus RepID=D2M1S7_BACS4
          Length = 508

 Score =  476 bits (1226), Expect = e-133,   Method: Composition-based stats.
 Identities = 115/521 (22%), Positives = 194/521 (37%), Gaps = 37/521 (7%)

Query: 45  EALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAKGVLPT 104
           E           + S  L    ++ +                      N ++A   +LP 
Sbjct: 2   EKFRQSIYDLIVETSTNLPYDVRRAIRKAKERENEGTRAALSLSTITNNIDMADDNILPI 61

Query: 105 CQDTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEVNTGTNL 164
           CQDTG      K           E+ + + +     +  LR +     D     N+G N+
Sbjct: 62  CQDTGMLTFEIKVPVG-ANQLEMEKDIFEAIRQATKDGKLRPNSV---DSLTGENSGDNI 117

Query: 165 PA---QIDLYAVDGDEYKFLCVAKGGGSANKTYLY---QETKALLTPGK----LKNFLVE 214
                 I  +  + D      + KGGG  NK   Y    E + L   G+    ++  ++ 
Sbjct: 118 GPGTPIIHFHQWEEDYIDARLIVKGGGCENKNIQYSLPMEIEGLGRAGRDLDGIRKCILH 177

Query: 215 KMRTLGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQ 274
            +       C    I   IGG      +   +LA    + E+    N+  +  +   LE+
Sbjct: 178 SVYQAQGQGCSAGFIGVGIGGD----RISGYELAKKQLFREV----NDVNENEKLQALEE 229

Query: 275 ELLEEAQKLGLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINREGI 333
            ++E+   LG+G   FGG+      ++  + R  AS  V +  +C A R +   ++    
Sbjct: 230 YIMEKGNTLGIGTMGFGGEATLLGCKIGTMNRLPASFFVSVAYNCWAFRRLGVTLDASTG 289

Query: 334 WIEKLEHNPGQYIPQELRQAG--EGEAVKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIV 391
            I+   +  G+ I  +  +A        +V L  P+ E   Q+    V   + + G +  
Sbjct: 290 EIQSWLYKEGEKISFKDDEAAATSEGTREVVLEAPITE--EQIRDLKVGDVVVINGDLHT 347

Query: 392 GRDIAHAKLKELIDAGKELPQYIKDHPIYYAGPAKTPAG---YPSGSLGPTTAGRMDSYV 448
           GRD  H  L E      + P  +    IY+ GP         +   + GPTT+ R + Y 
Sbjct: 348 GRDAIHHHLME-----NDAPIDLNGQVIYHCGPVMLKDKDGEWHVKAAGPTTSIREEPYQ 402

Query: 449 DLLQSHGGSMIMLAKGNRSQQVTDACHKHGGFYLGSIGGPAAVLAQQSIKHLECVAYPEL 508
             +    G   ++ KG    +   A  +HGG YL +IGG A   A   IK +E V   E 
Sbjct: 403 GDIMKKFGIRAVIGKGGMGPKTLKALEEHGGVYLNAIGGAAQYYA-DCIKKVEGVDLMEF 461

Query: 509 G-MEAIWKIEVEDFPAFILVDDKGNDFFQQIVNKQCANCTK 548
           G  EA+W ++VE F A + +D  GN   + +         +
Sbjct: 462 GIPEAMWHLKVEGFRAIVTMDSHGNSLHKDVDKTSFERLQQ 502


>UniRef50_C8PSZ3 Fumarate hydratase class I, anaerobic n=1 Tax=Treponema vincentii
           ATCC 35580 RepID=C8PSZ3_9SPIO
          Length = 567

 Score =  467 bits (1201), Expect = e-130,   Method: Composition-based stats.
 Identities = 234/546 (42%), Positives = 310/546 (56%), Gaps = 50/546 (9%)

Query: 40  LKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAK 99
           L V+   L    +QAF   SF     H + +  +  DP +SEND+ VA++ L N+ IAAK
Sbjct: 21  LTVDGSVLAAFTEQAFKRLSFTFPQEHLESLVDVACDPASSENDRLVAVKLLENAVIAAK 80

Query: 100 GVLPTCQDTGTAIIVGKKGQRVWTG----------GGDEETLSKGVYNTYIEDNLRYSQN 149
           G LP CQDTG A +   K   V T           G DEE  + GV   Y E+NLR+S N
Sbjct: 81  GTLPLCQDTGVAQVFAWKDAGVCTALTAAGGTVHFGSDEEAFTAGVGKAYKENNLRFSIN 140

Query: 150 AALDMYKEVNTGTNLPAQIDLYAVDG-----------------------DEYKFLCVAKG 186
               ++ E N+ TNLPAQ+D+++ +G                         Y+FL  AKG
Sbjct: 141 IPSSLFDEKNSATNLPAQVDIFSTNGAGTGTAEYAGSSCSNGTGSDSTEPSYRFLFCAKG 200

Query: 187 GGSANKTYLYQETKALLTPGKLKNFLVEKMRTLGTAACPPYHIAFVIGGTSAETNLKTVK 246
           GGS+NKT     TKALL P   + FL  K+  LGTAACPPY IA VIGG S E NL+T+K
Sbjct: 201 GGSSNKTDFTCATKALLNPQSFERFLKTKIAALGTAACPPYTIAVVIGGLSPEQNLQTLK 260

Query: 247 LASAHYYDELPTEGNEHG-----------QAFRDVQLEQELLEEAQKLGLGAQFGGKYFA 295
           LA+  Y+D         G           +  R    E+ +L+ A + GLGAQFGG + A
Sbjct: 261 LATTGYWDAAEALNKIGGSIRWTDTAGGVRPLRCRDWEERVLQIAAETGLGAQFGGSHLA 320

Query: 296 HDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINREGIWIEKLEHNPGQYIPQELRQAGE 355
              RV RLPRHGASC   +GVSC+A RN+   I+REG +++K   +P  +  +       
Sbjct: 321 AHARVFRLPRHGASCFASIGVSCNAHRNLVGYISREGAFLQKNVSDPRPFFEKAATYTAH 380

Query: 356 -----GEAVKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKEL 410
                GE V V+L+  +    A LS+YPV      +G I+V RD AHA+ K L+++GK L
Sbjct: 381 TAAHHGEPVAVELSS-IDAARAALSKYPVGQAFLFSGEILVARDAAHARWKALLESGKPL 439

Query: 411 PQYIKDHPIYYAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQV 470
           P Y   +PI YAGPA+TP G   GS GPTTA RMD Y D L S G ++I +AKGNRS+  
Sbjct: 440 PDYTLHYPILYAGPAETPKGAVIGSFGPTTANRMDPYADDLMSRGAALITIAKGNRSELW 499

Query: 471 TDACHKHGGFYLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDK 530
             AC K+G FYLG+IGG AA++A++ I   + + YP+LGMEA+  I V+D P F++ DDK
Sbjct: 500 RTACKKYGAFYLGTIGGAAALIAEKHITARKVLDYPDLGMEAVQLISVKDLPVFLITDDK 559

Query: 531 GNDFFQ 536
           GNDF+ 
Sbjct: 560 GNDFYA 565


>UniRef50_A8AAA8 Fumarase n=10 Tax=Archaea RepID=A8AAA8_IGNH4
          Length = 492

 Score =  460 bits (1185), Expect = e-128,   Method: Composition-based stats.
 Identities = 129/513 (25%), Positives = 205/513 (39%), Gaps = 36/513 (7%)

Query: 45  EALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAKGVLPT 104
           + +     +A   A   L     +++       E     K      L N E+A K   P 
Sbjct: 4   DEVVNAVVEAIRLAETALPKWVYEKLLDAYERSE--GLGKAQLAAILNNIELAVKEKKPM 61

Query: 105 CQDTGTAIIVGKKGQRVWT-GGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEVNTGTN 163
           CQDTG        G          EE L + V     E  +R +     D     N G N
Sbjct: 62  CQDTGLMTFDVIVGDEFPIKPYEIEELLKEAVRRATREVPIRPNSV---DPLSGHNPGDN 118

Query: 164 LP---AQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRTLG 220
           +       ++  V G+        KGGGS   + L     +    G ++  +++ +   G
Sbjct: 119 VGKGVPVTNIKVVPGNTLLIKVRPKGGGSEYPSNLCMIPPSKGLEG-VRECVLKAVFEAG 177

Query: 221 TAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLEEA 280
              CPP  +    GGT  E    T KLA    Y        E  +  R  ++E+ELL+E 
Sbjct: 178 GKPCPPGIVGVAFGGTVEE----TAKLAKEALYRP------EAHEEERVARIEKELLDEV 227

Query: 281 QKLGLGAQFGGKY-FAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINREGIWIEKLE 339
             LGLG    G    A  +R     RH AS PV +  +C A R    ++N +G W  KL 
Sbjct: 228 NSLGLGPMGLGGGPTALAVRADYAYRHPASFPVAVRFNCWAAREAVVEVNADGSW--KLV 285

Query: 340 HNPGQYIPQELRQAGEGEAVKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAK 399
            +     P++L+         V++  P++E   ++ +      + LTGT++  RD AH K
Sbjct: 286 SD--NVTPEDLKTPPLEAEDGVEIKLPVEE--EEVRKLKAGDVVYLTGTVVTARDEAHKK 341

Query: 400 LKELIDAGKELPQYIKDHPIYYAGPAKTPAG--YPSGSLGPTTAGRMDSYVDLLQSHGGS 457
           + E     +  P  +K   IY+ GP  T     +   + GPTT+ RM++    +    G+
Sbjct: 342 IIE-----EGAPLDLKGLAIYHCGPVVTKEEGRWKVVAAGPTTSARMNALQAQVLEKTGA 396

Query: 458 MIMLAKGNRSQQVTDACHKHGGFYLGSIGGPAAVLAQQSIKHLECVAYPELG-MEAIWKI 516
            +++ KG   + + D   + G  YL   GG A + A+            ELG  EA+W  
Sbjct: 397 RLVIGKGGMKEDLLDFFKRFGAAYLAFPGGAALLAAKAIKAVRGVYWLEELGIPEAMWVF 456

Query: 517 EVEDF-PAFILVDDKGNDFFQQIVNKQCANCTK 548
           EVE F P  + +D  G   ++++  +      +
Sbjct: 457 EVEKFGPLVVAMDSHGRSLYKEVSERAKTKLEE 489


>UniRef50_B1B7A5 Fumarase n=4 Tax=Bacteria RepID=B1B7A5_CLOBO
          Length = 279

 Score =  343 bits (881), Expect = 7e-93,   Method: Composition-based stats.
 Identities = 85/291 (29%), Positives = 130/291 (44%), Gaps = 13/291 (4%)

Query: 39  ILKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAA 98
           + ++  + +T   +     A++ L     K      ++ E S   K +  Q ++N  IAA
Sbjct: 1   MREINAQQITSAVKDIAIKANYFLGNDVIKA-LKDRYEKEESPVGKEILNQIMKNDNIAA 59

Query: 99  KGVLPTCQDTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEV 158
              +P CQDTG A++  + GQ V   G   + +++GV   Y E  LR S     +     
Sbjct: 60  SEHMPICQDTGVAVVFIELGQEVHVNGDISKAINEGVRQGYKEGYLRKSIVE--NPLYRK 117

Query: 159 NTGTNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRT 218
           NT  N PA I +  V GD+ K     KGGGS N + +          G +K F+VE +  
Sbjct: 118 NTSDNTPAVIYMKVVSGDKIKITIAPKGGGSENMSRIKMLKPLEGKEG-VKKFVVETISE 176

Query: 219 LGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLE 278
            G   CPP  +   IGGT  +  L   +      YD+         +  R   LE ELLE
Sbjct: 177 AGGNPCPPIVVGVGIGGTFEKAALMAKEALLRPIYDQ--------NKDTRIANLECELLE 228

Query: 279 EAQKLGLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKI 328
           E  KLG+G    GG+  +  +++   P H AS PV + ++C A R+    +
Sbjct: 229 EINKLGIGPMGLGGRTTSLAVKINTYPCHIASLPVAININCHAARHETIVL 279


>UniRef50_B2TIL9 Fumarate hydratase n=6 Tax=Clostridia RepID=B2TIL9_CLOBB
          Length = 280

 Score =  336 bits (863), Expect = 1e-90,   Method: Composition-based stats.
 Identities = 88/292 (30%), Positives = 131/292 (44%), Gaps = 14/292 (4%)

Query: 39  ILKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAA 98
           + +V  + +    ++    A++ L     +Q      D E     + +  + + NSEIA 
Sbjct: 1   MREVNVDCIIDAVKELSIKANYFLG-EDIRQALEDSRDKETWNLAEDILDKIIINSEIAD 59

Query: 99  KGVLPTCQDTGTAIIVGKKGQRV-WTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKE 157
           K  +P CQDTG A +  + GQ V   GG   E +++GV   Y E  LR S     +  K 
Sbjct: 60  KEHVPICQDTGMACVFVELGQDVHLIGGNLSEAINEGVRMGYEEGFLRKSVVE--NPLKR 117

Query: 158 VNTGTNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMR 217
           +NT  N PA I    V GD+ K     KG GS N + +     +    G +K F++E +R
Sbjct: 118 INTNDNTPAVIYYDIVPGDKIKITVAPKGFGSENMSKITMLKPSDGVEG-VKEFILEVVR 176

Query: 218 TLGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELL 277
             G   CPP  I   IGGT  +    +  LA       +    N          LE ELL
Sbjct: 177 QAGPNPCPPMVIGVGIGGTFDK----SAYLAKKALLRPI----NIRNDDEYYKDLEIELL 228

Query: 278 EEAQKLGLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKI 328
           E+  +LG+G Q FGG+  A  + +   P H A  PV + ++C A R+ +  I
Sbjct: 229 EKINELGIGPQGFGGRTTALGLNIETYPTHIAGLPVAVNINCHATRHKEIII 280


>UniRef50_B1I426 Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit
           n=135 Tax=cellular organisms RepID=B1I426_DESAP
          Length = 294

 Score =  328 bits (840), Expect = 5e-88,   Method: Composition-based stats.
 Identities = 82/292 (28%), Positives = 124/292 (42%), Gaps = 14/292 (4%)

Query: 39  ILKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAA 98
           +  ++ E +     +   +A+++L P             E S   K V  Q L N+ IA 
Sbjct: 15  VRTLDCEKVVEATSRLCREANYVLEPDVV-AALEGARQEEVSPTGKDVLGQLLENARIAV 73

Query: 99  KGVLPTCQDTGTAIIVGKKGQRV-WTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKE 157
           +  +P CQDTG A++  + GQ +   GG  EE + +GV   Y +  LR S  A  D    
Sbjct: 74  REEIPLCQDTGIAVVFVEVGQDLRIVGGSLEEAVVRGVREGYEQGYLRKSVVA--DPLNR 131

Query: 158 VNTGTNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMR 217
           VNTG N P  I    V GD  K   + KG GS N + L     A    G +K F++E + 
Sbjct: 132 VNTGDNSPPVIHWRLVPGDRLKISVMPKGAGSENMSALKMLKPAEGLDG-VKRFILETVS 190

Query: 218 TLGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELL 277
           + G   CPP  +   +GGT  +  L           + L              +LE+ L 
Sbjct: 191 SAGPNPCPPLVVGVGLGGTMEKAALLAK--------EALLRPLGTRNPVAELAELEENLR 242

Query: 278 EEAQKLGLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKI 328
               +LG+G    GG+     + +   P H A  PV + ++C A R+  A +
Sbjct: 243 VFLNELGIGPMGLGGRVTVLAVHLSTYPTHIAMLPVAVNLNCHAVRHKTAVL 294


>UniRef50_B4SZG5 Fumarate hydratase n=21 Tax=Salmonella enterica RepID=B4SZG5_SALNS
          Length = 281

 Score =  327 bits (839), Expect = 6e-88,   Method: Composition-based stats.
 Identities = 83/291 (28%), Positives = 120/291 (41%), Gaps = 14/291 (4%)

Query: 40  LKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAK 99
             +  E +  + ++    A + L   +        +D E S+  K      + N E A K
Sbjct: 3   RILNTEIIIPVIEKLVKKACYELD-DNLMCSFRKAYDKEESKIGKETIKILIDNGEYAKK 61

Query: 100 GVLPTCQDTGTAIIVGKKGQRVWTGG-GDEETLSKGVYNTYIEDNLRYSQNAALDMYKEV 158
             L  C DTGT I++ + GQ V   G   ++ +++GV   Y    LR S  A  D  + +
Sbjct: 62  EQLACCHDTGTCIVIMEIGQHVCWEGKPLKDQVNQGVRQGYENGYLRKSMVA--DPLERI 119

Query: 159 NTGTNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRT 218
           NT  N PA +    VDGD      + KGGGS N              G +K+F++E +R 
Sbjct: 120 NTNDNTPAILHTEIVDGDRVTITVMPKGGGSENMGTFKTLLPGDGIDG-IKDFVLETVRR 178

Query: 219 LGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLE 278
           +G   CPPY I   +GGT    +      A       L     E        QLE ELLE
Sbjct: 179 VGGNPCPPYIIGIGVGGTMDHCSWM----AKKALLRPL----GEFNAKPLYAQLEAELLE 230

Query: 279 EAQKLGLGA-QFGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKI 328
                G+G    GG+  A  + V   P H  + PV +   C+A R+    I
Sbjct: 231 AVNNTGIGPLGMGGRITALGVHVDYYPCHITALPVAINFQCNASRHASEII 281


>UniRef50_Q312U0 Fumarase alpha subunit n=1 Tax=Desulfovibrio desulfuricans subsp.
           desulfuricans str. G20 RepID=Q312U0_DESDG
          Length = 279

 Score =  326 bits (837), Expect = 9e-88,   Method: Composition-based stats.
 Identities = 85/292 (29%), Positives = 128/292 (43%), Gaps = 15/292 (5%)

Query: 39  ILKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAA 98
           +  ++   L    +    DA+ +L               E +++ K V  Q L N+++AA
Sbjct: 1   MKSIKAADLHAAVRDMIMDANRVLGKDV-YNAFQTCMQQETTDSGKEVLRQLLENADLAA 59

Query: 99  KGVLPTCQDTGTAIIVGKKGQRV-WTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKE 157
           +  L  CQDTG A+   + G+ V   GGG +ETL+  +   Y +  LR S          
Sbjct: 60  QSGLALCQDTGVAVFFVEMGEEVRMEGGGLKETLNAAMVEAYNKAFLRKSMCHP---LTR 116

Query: 158 VNTGTNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMR 217
            NTG N PA I +  V GD  K   +AKGGGS N +     T A    G +K+F+V +M 
Sbjct: 117 KNTGDNTPAVIHVELVPGDTLKVRYMAKGGGSENMSRCTMLTPAQGWQG-IKDFVVRRMA 175

Query: 218 TLGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELL 277
             G   CPP  +   IGGT          LA    +       ++         +E+ELL
Sbjct: 176 EAGPNPCPPTIVGVGIGGTFD----LAPSLAKGALFR----RVDDVHPDPEIAAMEKELL 227

Query: 278 EEAQKLGLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKI 328
           +E   LG+G    GGK     +++   P H AS P+ + V C + R+ +   
Sbjct: 228 DEINALGIGPMGLGGKTTCLAVKIAMHPCHIASLPLAVNVQCHSSRHKEVVF 279


>UniRef50_Q1LBZ5 Fumarase alpha subunit n=20 Tax=Bacteria RepID=Q1LBZ5_RALME
          Length = 280

 Score =  321 bits (823), Expect = 4e-86,   Method: Composition-based stats.
 Identities = 82/292 (28%), Positives = 124/292 (42%), Gaps = 14/292 (4%)

Query: 39  ILKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAA 98
           + ++  + LT    +   DA   L P +  +      + E S   K V ++ + N  IA 
Sbjct: 1   MREIHVDTLTDAVAKLCIDACHRL-PDNLVESFHKAAEKEVSPLGKSVLMKLIDNDRIAR 59

Query: 99  KGVLPTCQDTGTAIIVGKKGQRV-WTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKE 157
           +  +  C DTG AI+  + GQ V   GG  E+ +  GV   Y E  +R S  +  D    
Sbjct: 60  ENDVSYCHDTGLAIVFVEVGQDVHIVGGSYEDAIQAGVRKGYAEGYMRKSVVS--DPLLR 117

Query: 158 VNTGTNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMR 217
           VN+  N PA +    V GD  +   V KGGGS N + +          G +K F++  + 
Sbjct: 118 VNSNDNTPAVVHTEIVPGDNIEVTVVPKGGGSENWSTMKFLLPGEGAEG-VKKFVLSAIE 176

Query: 218 TLGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELL 277
             G AACPP  +   IGG+  +      K         +  +   H +     +LE ELL
Sbjct: 177 AAGGAACPPLTVGVGIGGSFDKVTAIAKKA--------ILRDIGVHHKEPHVAKLEAELL 228

Query: 278 EEAQKLGLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKI 328
           +   K G+G Q +GG   A  + V     H  + PV + + C A R   A I
Sbjct: 229 DAINKTGIGPQGYGGVNTALWVSVETYACHITALPVAVNIQCHAGRRATAVI 280


>UniRef50_B1GZT9 Fumarate hydratase alpha subunit n=1 Tax=uncultured Termite group 1
           bacterium phylotype Rs-D17 RepID=B1GZT9_UNCTG
          Length = 279

 Score =  321 bits (823), Expect = 5e-86,   Method: Composition-based stats.
 Identities = 81/292 (27%), Positives = 124/292 (42%), Gaps = 15/292 (5%)

Query: 39  ILKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAA 98
           + K++ E +    +    + +F L     K +   +      +  K +  + + N++IA 
Sbjct: 1   MRKIKSEIIINAIENLCAETNFKLPADVLKSLEQNIVL--EKDTAKDILKEIIENADIAR 58

Query: 99  KGVLPTCQDTGTAIIVGKKGQRVWT-GGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKE 157
           K  +P CQDTGTA    K G+      G     ++KGV   Y    LR S   A +  + 
Sbjct: 59  KEQIPLCQDTGTANFFIKLGRDTEIENGDIYAAVNKGVSLGYTNSYLRKSV--ASNPLER 116

Query: 158 VNTGTNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMR 217
            NT  N PA I +  V GD+ +   + KGGGS N + L     ++   G ++ F++  + 
Sbjct: 117 KNTKDNTPANIYIDLVSGDKIEITFLPKGGGSENASALKMLVPSVGWDG-IREFVLSAVD 175

Query: 218 TLGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELL 277
             G  ACPP  +   IGG  A   L + K         L  E     +    V  E ELL
Sbjct: 176 DKGRNACPPLVVGIGIGGDFASVGLMSKKA--------LLREIGSENKNVFYVGKEMELL 227

Query: 278 EEAQKLGLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKI 328
            +  KL +G    GGK  A  + +   P H AS PV + + C + R     I
Sbjct: 228 NDINKLNIGPMGMGGKTTALAVFIEAKPVHIASLPVAVNIQCHSCRRKTVMI 279


>UniRef50_Q469V4 Fumarase alpha subunit n=6 Tax=Archaea RepID=Q469V4_METBF
          Length = 280

 Score =  321 bits (822), Expect = 6e-86,   Method: Composition-based stats.
 Identities = 78/295 (26%), Positives = 110/295 (37%), Gaps = 23/295 (7%)

Query: 41  KVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAKG 100
           K+  E+               L P             E ++  K+     L+N EIA K 
Sbjct: 4   KISRESFIRSIADLLRKTETEL-PDDVVNAIRKAEAAEENKVAKFQLRAILKNLEIAKKY 62

Query: 101 VLPTCQDTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEVNT 160
            +P CQDTG  I   + G     G   E  + + V     E  LR +   A+D     N+
Sbjct: 63  RVPMCQDTGIMIFFAEIGSEFQPGFDLEAAIREAVILATTEIPLRPN---AVDPLTRKNS 119

Query: 161 GTNLP---AQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMR 217
           G N       I    V G++ K     KG GS N + L          G +KNF++E + 
Sbjct: 120 GNNTGVGIPDIHWKLVPGNQLKITAAPKGAGSENMSSLRMFNPTE--TGSIKNFVLETIV 177

Query: 218 TLGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELL 277
           T G   CPP  I   IGG+         +LA     + L               LE+E+ 
Sbjct: 178 TAGGMPCPPLTIGIGIGGSFDA----AARLAKESLLEPLDAP---------MEGLEREIF 224

Query: 278 EEAQKLGLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINRE 331
           E    LG+G    GG   A  +RV     H AS PV + + C A+R+       +
Sbjct: 225 EAVNTLGIGCMGLGGSTTALAVRVKTAHCHTASLPVAVNIQCWANRHASVVFGGD 279


>UniRef50_A6Q389 Fumarate/tartrate hydratase, alpha subunit n=9 Tax=Bacteria
           RepID=A6Q389_NITSB
          Length = 287

 Score =  310 bits (794), Expect = 9e-83,   Method: Composition-based stats.
 Identities = 86/300 (28%), Positives = 120/300 (40%), Gaps = 23/300 (7%)

Query: 39  ILKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAA 98
           +  V  E +    +     ++  L     K +   L + E S   K V  Q L N+EIAA
Sbjct: 1   MRTVAYEDIVKAIRDTIIYSTTHLSEDMHKALQEAL-EKEESLVSKAVLEQLLENAEIAA 59

Query: 99  KGVLPTCQDTGTAIIVGKKGQRVWT-GGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKE 157
               P CQDTG AI   K G+ V   GG  +E + +G    Y E  LR S     D +  
Sbjct: 60  SENKPLCQDTGLAIFFVKVGEDVRVEGGSLKEAIFEGTKKGYEEGYLRASTC---DCFTR 116

Query: 158 VNT----GTNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLV 213
            N     G NLP  I    V GD+ +    AKGGGS N +       A    G +K F+ 
Sbjct: 117 ANLKDKIGYNLPPVIYFDIVPGDKIEIEFAAKGGGSENGSRARVLAPAQGKEG-IKEFVK 175

Query: 214 EKMRTLGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLE 273
           + +   G   CPP  +   IGG+     + +           L  +             E
Sbjct: 176 QVVSDAGPNVCPPIVVGVGIGGSFDYAAVMSKHA--------LFRDIGTPNPDPELDAFE 227

Query: 274 QELLEEAQKLGLGAQ-FGGKYFAHDIRVIRLP----RHGASCPVGMGVSCSADRNIKAKI 328
           +E+LEE  KLG+GA   GG   A  + +         H AS PV + + C + R+    I
Sbjct: 228 KEILEELNKLGIGAMGMGGTQTALAVHIETYKPGRMCHIASLPVAVNIQCHSSRHAHITI 287


>UniRef50_A6T6H6 Tartrate dehydratase n=1 Tax=Klebsiella pneumoniae subsp.
           pneumoniae MGH 78578 RepID=A6T6H6_KLEP7
          Length = 281

 Score =  306 bits (784), Expect = 1e-81,   Method: Composition-based stats.
 Identities = 80/291 (27%), Positives = 120/291 (41%), Gaps = 14/291 (4%)

Query: 40  LKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAK 99
             +  E +  + ++    A + L   +        ++ E S+  K      + N E A K
Sbjct: 3   RILNTEVIVPVIEELVKKACYELD-DNLMCAFRKAYEKEESKLGKETIKILIDNGEYAKK 61

Query: 100 GVLPTCQDTGTAIIVGKKGQRVWTGG-GDEETLSKGVYNTYIEDNLRYSQNAALDMYKEV 158
             L  C DTGT I++ + GQ V   G   ++ +++GV   Y +  LR S  A  D    +
Sbjct: 62  EQLACCHDTGTCIVIMEIGQEVCWEGFSLQQQVNQGVRQGYEKGYLRKSMVA--DPLDRI 119

Query: 159 NTGTNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRT 218
           NT  N PA +    V+GD      + KGGGS N              G +K F++E +R 
Sbjct: 120 NTNDNTPAVLHTEIVEGDRVTITVMPKGGGSENMGTFKTLLPGDDIEG-VKRFVLETVRH 178

Query: 219 LGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLE 278
           +G   CPPY I   IGGT         K         L     E+       +LE ELL+
Sbjct: 179 VGGNPCPPYIIGIGIGGTMDHCAWMAKKA--------LLRPIGEYNAKPLYAKLEAELLD 230

Query: 279 EAQKLGLGA-QFGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKI 328
           E    G+G    GG+  A  + +   P H  + PV +   C+A R+    I
Sbjct: 231 EVNNTGIGPLGMGGRVTALGVHIDYYPCHITALPVAINFQCNASRHASKTI 281


>UniRef50_Q0RXW8 Fumarate hydratase, class I n=2 Tax=Bacteria RepID=Q0RXW8_RHOSR
          Length = 301

 Score =  305 bits (781), Expect = 3e-81,   Method: Composition-based stats.
 Identities = 73/305 (23%), Positives = 121/305 (39%), Gaps = 20/305 (6%)

Query: 37  ETILKVEPEAL----TLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLR 92
            T++++ PE+L    T L+   +  A   L P  +  V  +     A    +      + 
Sbjct: 4   RTMVELAPESLYRDLTELSAHLYKKALTDLPPDVRSAVHRVAEQEVAG--ARRRLDVMVN 61

Query: 93  NSEIAAKGVLPTCQDTGTAIIVGKKGQRVWTGG-GDEETLSKGVYNTYIEDNLRYSQNAA 151
           + +I+ +  +  CQDTG  +   + G      G      L  GV     + +LR S    
Sbjct: 62  SIDISDRTGIIVCQDTGICVFFVRLGTEFPVNGAKLINALRNGVALATKQHDLRSSIVHP 121

Query: 152 LDMYKE-VNTGTNLPAQIDLYAVDG-DEYKFLCVAKGGGSANKTYLYQETKALLTPGKLK 209
           +       NTG  +P  + +  VDG DE + L V KG GS N +YL   + +    G +K
Sbjct: 122 ITRENRQDNTGVGIP-DVHVEFVDGSDELEILLVPKGSGSENMSYLKMLSPSEGITG-VK 179

Query: 210 NFLVEKMRTLGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRD 269
            F+++ +   G   CPP  +   IGGT+         LA       +     E       
Sbjct: 180 RFVLDSVIDAGPRPCPPTVVGVGIGGTAD----LCAALAKKAILRPV----GEPHPEPEI 231

Query: 270 VQLEQELLEEAQKLGLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKI 328
             +E++LL    + G+G Q  GG   +  + V     H +  PV + + C       A I
Sbjct: 232 AAIEKQLLAAINETGIGPQGLGGNVTSFAVHVEYSATHISMNPVAVNIQCWRGERASATI 291

Query: 329 NREGI 333
           + +G 
Sbjct: 292 STDGA 296


>UniRef50_A2BJ70 L(+)-tartrate dehydratase class I, alpha subunit n=7 Tax=cellular
           organisms RepID=A2BJ70_HYPBU
          Length = 294

 Score =  302 bits (774), Expect = 2e-80,   Method: Composition-based stats.
 Identities = 76/298 (25%), Positives = 111/298 (37%), Gaps = 16/298 (5%)

Query: 47  LTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAKGVLPTCQ 106
           L     +    A   L P           + E +   K      LRNSE+AAK   P CQ
Sbjct: 8   LREFLVELIRVAETRL-PLDVYNALKKALEVEDNPIAKQHLEAILRNSELAAKLGKPICQ 66

Query: 107 DTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEVNTGTNLP- 165
           DTGT +   + G+         E  ++ V        LR +    +   +  NTG N   
Sbjct: 67  DTGTPVFYIRLGEEFPLRAKIYEVATEAVREATRLIPLRPNAVNPI---RGGNTGDNTGR 123

Query: 166 --AQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRTLGTAA 223
                D+  V GD  +   VAKGGGS   + L            +   +++ + + G   
Sbjct: 124 HIPWFDVEIVPGDRLEVTFVAKGGGSEAPSTLNMALPIRGIR-NVWETVLKAVVSAGPKP 182

Query: 224 CPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLEEAQKL 283
           CPP  +   I     +      K A       L     E        +LE++LL+    L
Sbjct: 183 CPPVVVGVGIAALGEQALAIARKAA-------LLRPLGERHPEPEIAELEEKLLDAINSL 235

Query: 284 GLGA-QFGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINREGIWIEKLEH 340
           G+G   FGGK  A D+ +    RH A+  VG+  +C A R     I  +G W    +H
Sbjct: 236 GIGVHGFGGKITALDVHIDYAHRHPATYAVGVVFNCWAIRRATGYITPDGRWEITSKH 293


>UniRef50_Q0W345 Fumarate hydratase (Fumarase), alpha subunit n=12 Tax=cellular
           organisms RepID=Q0W345_UNCMA
          Length = 288

 Score =  301 bits (772), Expect = 3e-80,   Method: Composition-based stats.
 Identities = 71/292 (24%), Positives = 101/292 (34%), Gaps = 19/292 (6%)

Query: 47  LTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAKGVLPTCQ 106
           +   A +    A   L               E+ +  K      + N   A +  LP CQ
Sbjct: 7   IEDAAVELIRRAVTRLPAGVI-AELERAERTESQDTPKRELRAMIENVREAGRCTLPMCQ 65

Query: 107 DTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEVNTGTNLP- 165
           DTG  +     G   +   G EE L+  V     E  LR +           NTG N   
Sbjct: 66  DTGIPLFFVTVGS--FRVKGLEEVLAAAVRKATTEVPLRKNVVHP---LTRANTGDNTGT 120

Query: 166 --AQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRTLGTAA 223
               I     D +  +   + KG GS N + L     +    G ++ F+VE +       
Sbjct: 121 DMPHIAYSFHDAEYMEISYMPKGAGSENMSALAMLNPSQGVQG-IRKFVVETIAKAEGKP 179

Query: 224 CPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLEEAQKL 283
           CPP  I   +GG+S                  L     E        +LE ELLE   + 
Sbjct: 180 CPPVIIGVGLGGSSDMCMAMAK--------RALLRPVGEKNADPEMAKLEAELLELINRT 231

Query: 284 GLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINREGIW 334
           G+G    GG+  A  + V     H AS PVG+ V C A R    ++  +G  
Sbjct: 232 GVGPMGLGGRTTALAVHVEWASCHTASLPVGLNVQCYAARRATIRVYPDGRT 283


>UniRef50_B2KBV3 Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit
           n=2 Tax=Bacteria RepID=B2KBV3_ELUMP
          Length = 279

 Score =  301 bits (770), Expect = 6e-80,   Method: Composition-based stats.
 Identities = 76/291 (26%), Positives = 123/291 (42%), Gaps = 13/291 (4%)

Query: 39  ILKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAA 98
           + +++   +T         A+  L  +              S  +K +   +L+N+ IA 
Sbjct: 1   MRQIKSSDITKTIASLCKQANIELPNSTVCSF--AACAKRCSGREKEIFNIYLKNASIAK 58

Query: 99  KGVLPTCQDTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEV 158
             +LP CQDTG  ++  + G  V   G   + ++KGV   Y ++ LR S      ++  V
Sbjct: 59  GQLLPICQDTGITVVFLEIGVGVLIKGDLYKAVNKGVSLGYKKNFLRASVVK-DPLFGRV 117

Query: 159 NTGTNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRT 218
           NT  N PA I    V G + K   V KG G+ N + L     +      +K+F+V  ++ 
Sbjct: 118 NTKDNTPAVIYTKIVKGSKIKITVVPKGAGAENMSALKMFNPSAPIEE-IKDFIVNTVKQ 176

Query: 219 LGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLE 278
                CPP  +   +GGT                   L  E     +      LE+++L+
Sbjct: 177 ADANPCPPVVVGVGVGGTFDYCAFMAKHA--------LTNEIGRVNKDKNYASLEKDILK 228

Query: 279 EAQKLGLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKI 328
           +  KLG+G Q FGGK  A  + +   P H AS PV + + C   R+ KA +
Sbjct: 229 KINKLGIGPQGFGGKNTALAVFIEHAPCHMASLPVAVNIGCHVHRHAKAVL 279


>UniRef50_B1L7M6 Tartrate dehydratase alpha subunit/Fumarate hydratase class I,
           N-terminal domain protein n=3 Tax=Archaea
           RepID=B1L7M6_KORCO
          Length = 292

 Score =  301 bits (770), Expect = 6e-80,   Method: Composition-based stats.
 Identities = 75/291 (25%), Positives = 125/291 (42%), Gaps = 17/291 (5%)

Query: 46  ALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAKGVLPTC 105
           ++     +   +A+F +    +  +    ++ E +   +      L+N + + K  +P C
Sbjct: 7   SIIDGIVKMMREAAFNVPKDVKDALIK-AYESEDNPVARANLEAILKNIDASGKLKMPMC 65

Query: 106 QDTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEVNTGTNLP 165
           QDTGT     + G         +  + + V     E  LR +     + +   N G N  
Sbjct: 66  QDTGTPTFFIELGDDFPLRSEVKSVIEEAVRRATAEIPLRPNTV---NPWTGENPGDNTG 122

Query: 166 ---AQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRTLGTA 222
                I L  V GD+ + L +AKGGGS N + +Y  +  L   G +K  +++ M   G  
Sbjct: 123 RHVPIIHLDLVPGDQMRVLFLAKGGGSENTSKIYMLSPVLGIKG-IKKAVIDAMIDAGPM 181

Query: 223 ACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLEEAQK 282
            CPP  +   +GG++       +KLA    +  L    NE     +  +LE ELLE    
Sbjct: 182 PCPPIIVGVGVGGSAD----LAIKLAKKATFRRL----NEPNPDPKLNELENELLEMINS 233

Query: 283 LGLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINREG 332
           LG+G    GGK +A  ++V    +H AS PVG+   C A R  +   ++ G
Sbjct: 234 LGIGPMGLGGKTYALGVKVEWAHKHPASLPVGISTQCWAFRRAEGIFDKNG 284


>UniRef50_Q58690 Putative fumarate hydratase subunit alpha n=18 Tax=Euryarchaeota
           RepID=FUMA_METJA
          Length = 285

 Score =  300 bits (768), Expect = 1e-79,   Method: Composition-based stats.
 Identities = 81/291 (27%), Positives = 124/291 (42%), Gaps = 15/291 (5%)

Query: 46  ALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAKGVLPTC 105
            ++ +  + F +A+  L P   K      +  E+SE  K      + N++IA +  +P C
Sbjct: 2   KISDVVVELFREAAIYL-PEDVKNALEEAYKKESSEISKNTLKAIIENNKIAEETQVPLC 60

Query: 106 QDTGTAIIVGKKGQRVWTGG--GDEETLSKGVYNTYIEDNLRYSQNAALDMYK-EVNTGT 162
           QDTG  I+  K G+ + +       E + +GV     E  LR +    L     + N G 
Sbjct: 61  QDTGVPIVFLKIGKNINSSEIMKIIEEIKEGVKKATEEVPLRPNVVHPLTRENFKTNVGL 120

Query: 163 NLP-AQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRTLGT 221
           N P   I+       E + +   KG GS N + L     +    G +KNF++E +   G 
Sbjct: 121 NSPFINIEFDESLDREIEIIAFPKGAGSENMSALKMLKPSDGIEG-IKNFVLETIANAGG 179

Query: 222 AACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLEEAQ 281
             CPP  +   IGGT+        K         L  +  E  +      LE+ELLE+  
Sbjct: 180 KPCPPIVVGIGIGGTADVALKLAKK--------ALLRKIGERHRDKEIANLEKELLEKIN 231

Query: 282 KLGLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINRE 331
            LG+GA   GG   A D+ +     H AS PVG+ + C ADR    +I  +
Sbjct: 232 SLGIGAMGLGGDITALDVFIEIAGCHTASLPVGICIQCWADRRAIKRIKLD 282


>UniRef50_Q2RG69 Fumarase alpha subunit n=13 Tax=Bacteria RepID=Q2RG69_MOOTA
          Length = 281

 Score =  299 bits (767), Expect = 1e-79,   Method: Composition-based stats.
 Identities = 85/291 (29%), Positives = 116/291 (39%), Gaps = 14/291 (4%)

Query: 40  LKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAK 99
             +  + +T         A++ L     +         E S   K V  Q L N+ IAA 
Sbjct: 3   RIITCDEITRAVADLCRQANYYLG-EDVRGALEGALAREVSPQGKDVLNQLLENAAIAAA 61

Query: 100 GVLPTCQDTGTAIIVGKKGQRVWTGGG-DEETLSKGVYNTYIEDNLRYSQNAALDMYKEV 158
             +P CQDTG A++  + GQ V   GG   + ++ GV   Y E  LR S           
Sbjct: 62  EEVPICQDTGVAVVFLELGQEVQVQGGYLYDAINAGVRQGYTEGYLRKSMVYP--PLDGR 119

Query: 159 NTGTNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRT 218
           NTG N PA I    V GD+       KGGGS N +       A    G +K F++E ++ 
Sbjct: 120 NTGDNTPAIIHTEIVPGDKLTITVAPKGGGSENMSAAVMLAPAAGIRG-VKEFVLETVKK 178

Query: 219 LGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLE 278
            G   CPP  +   IGG   +  L    LA       L     E         LE++LLE
Sbjct: 179 AGPNPCPPLIVGVGIGGNFEKCAL----LAKKALLRPL----GEPHPLEGIATLERDLLE 230

Query: 279 EAQKL-GLGAQFGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKI 328
               L      FGG+  A  + V    RH AS PV + + C A R+    +
Sbjct: 231 SINCLGIGPGGFGGRMTALAVHVEIFARHIASLPVAVNIQCHAARHKSITL 281


>UniRef50_A2SQV2 Fumarase alpha subunit n=2 Tax=Methanomicrobiales
           RepID=A2SQV2_METLZ
          Length = 273

 Score =  298 bits (764), Expect = 3e-79,   Method: Composition-based stats.
 Identities = 58/285 (20%), Positives = 107/285 (37%), Gaps = 22/285 (7%)

Query: 47  LTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAKGVLPTCQ 106
           L    ++A H A  +L P   ++     ++ E +   +        N ++A +  +P CQ
Sbjct: 8   LASAVEEAIHQAETILPPDV-EEALHTAYNKETNPTARGEFENIFANLQVAREKNVPICQ 66

Query: 107 DTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEVNTGTNLPA 166
           DTG  +I     + V       + +S+G+        LR +           N+G N  A
Sbjct: 67  DTGIFVIYLTIPETVPLTTKLYDAVSEGIRLATKSVPLRPNAVHP---LTRKNSGDNTGA 123

Query: 167 QID-LYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRTLGTAACP 225
            I  ++ + GD  +     KG GS N + +     + +   ++  F+   ++  G+  CP
Sbjct: 124 GIPAVHILPGDTLRVTVFPKGAGSENMSQIRMMLPSEI--SRIPEFVTSVVKDAGSRPCP 181

Query: 226 PYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLEEAQKLGL 285
           P  +   IGGT           A       + +              EQ++ +   +LG+
Sbjct: 182 PIVVGVGIGGTFDS----AASFAKEALLSPINS----------MTAFEQKICDSINQLGI 227

Query: 286 GAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKIN 329
           G    GG      ++V     H AS PV + + C   R    ++ 
Sbjct: 228 GVMGLGGDTTCLAVKVKEGACHTASLPVAVNIQCWCSRRGVVEVE 272


>UniRef50_A9HYF3 Fumarate hydratase alpha subunit n=3 Tax=Proteobacteria
           RepID=A9HYF3_BORPD
          Length = 292

 Score =  297 bits (760), Expect = 8e-79,   Method: Composition-based stats.
 Identities = 71/298 (23%), Positives = 116/298 (38%), Gaps = 13/298 (4%)

Query: 39  ILKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAA 98
           + +++   +   A++ +  A   L P   KQ    L   E+S+  + +      N  +A 
Sbjct: 1   MSEIDYAQVEDAARELYIRALKRL-PDDIKQGFERLRGAESSDRARSILDTMTTNIAVAE 59

Query: 99  KGVLPTCQDTGTAIIVGKKGQRVWTGGG-DEETLSKGVYNTYIEDNLRYSQNAALDMYK- 156
                 CQDTG  I     G+RV   G   ++ +  G      E  LR S    +     
Sbjct: 60  AHDNLLCQDTGIPIYNVLVGRRVALDGWRLKQAIRAGCERATREHPLRSSVVHPISRKNA 119

Query: 157 EVNTGTNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKM 216
             + G  +P     +  D + ++   + KG GS N ++L     A      +K F+++ +
Sbjct: 120 HTSCGPGVPVIHVDFCEDDERFEIEMIPKGSGSENNSFLRMAIPAEGLDA-VKTFVIDCV 178

Query: 217 RTLGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQEL 276
              G   CPP  +   +GGTS       V LA       L +  +         QLEQEL
Sbjct: 179 MQAGGKTCPPTIVGVGVGGTSD----LCVHLAKQAATRPLGSRCD----DPLGAQLEQEL 230

Query: 277 LEEAQKLGLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINREGI 333
                +LG+G Q  GG   A  + V     H    PV + + C + R  +A +   G+
Sbjct: 231 SAAVNQLGVGPQGLGGDATAFAVHVELAATHITMNPVAVNMQCHSARRARATLTPNGV 288


>UniRef50_B8GKW0 Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit
           n=1 Tax=Methanosphaerula palustris E1-9c
           RepID=B8GKW0_METPE
          Length = 282

 Score =  293 bits (750), Expect = 1e-77,   Method: Composition-based stats.
 Identities = 64/288 (22%), Positives = 100/288 (34%), Gaps = 21/288 (7%)

Query: 46  ALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAKGVLPTC 105
            +T     A   A   L    +  +       E            L N   A K  +P C
Sbjct: 14  KVTEATVSACRKAVIYLPEDVKHVLKKARKKNELDPVALGELENILDNLACAEKYQVPLC 73

Query: 106 QDTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEVNTGTNLP 165
           QDTG  ++       V       + +  GV     E  LR +     D    VN+G N  
Sbjct: 74  QDTGVLVVYMTIPPTVPLTEELYDAVRAGVRRATAEVPLRPNVV---DPITRVNSGDNTG 130

Query: 166 AQID-LYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRTLGTAAC 224
             +  ++   G       + KG G+ N + +     +     +++ F+V+ +   G+  C
Sbjct: 131 EGMPAIHVRPGATLSITVLPKGAGAENTSQIAMLLPSQ--KDRIEEFVVKTVLEAGSRPC 188

Query: 225 PPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLEEAQKLG 284
           PP  I   IGGT  E       LA       +           R    EQ L +    LG
Sbjct: 189 PPLVIGIGIGGTFDE----VAALAKEALLQPI----------DRMDLFEQGLCDTLNTLG 234

Query: 285 LGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINRE 331
           +G    GGK     +++ +   H AS PV + V C A+R     +  +
Sbjct: 235 IGPMGLGGKTSVLAVKMKKGACHTASLPVAVNVQCWANRRATIVVEVD 282


>UniRef50_A4YFS7 Fumarase alpha subunit n=1 Tax=Metallosphaera sedula DSM 5348
           RepID=A4YFS7_METS5
          Length = 294

 Score =  293 bits (749), Expect = 2e-77,   Method: Composition-based stats.
 Identities = 67/289 (23%), Positives = 117/289 (40%), Gaps = 19/289 (6%)

Query: 49  LLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAKGVLPTCQDT 108
            +++  ++ A  ++     +++    ++ E SE  + V    ++N E+A K  L  CQDT
Sbjct: 12  EVSETLYYKALTVIPKDVVERIGK-AYEMEQSELGRRVLDTIMKNIEVATKRNLLVCQDT 70

Query: 109 GTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEVNTGTNLP--- 165
           GT +   + G    +     +++++GV    ++ +LR +    +      NTG N     
Sbjct: 71  GTPVYSVELGDFEISLPKLRDSIARGVRKATLKYHLRPNMVHPI---TRENTGDNTGRSS 127

Query: 166 AQIDLYAVDG--DEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRTLGTAA 223
             I     +   D+ +   + KG GS N + L     A    G  K F++E +   G   
Sbjct: 128 PIIHFEINEELKDKIRITALPKGSGSENMSSLKMLRPADGILGA-KKFVLETIANAGGKG 186

Query: 224 CPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLEEAQKL 283
           CPPY +   IGG     +     LA       +              +LE+EL      L
Sbjct: 187 CPPYIVGVGIGGDFESVS----HLAKRAVMRPV----GSRSSDPEGAKLEEELFYLVNGL 238

Query: 284 GLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINRE 331
           G+G    GGK+ A  + V     H +S PV + V C       A++  +
Sbjct: 239 GVGPMGVGGKFTAIGVHVEIGETHISSLPVAVNVQCWRGERATAEVTLD 287


>UniRef50_A4WJ46 Fumarase alpha subunit n=2 Tax=Thermoproteaceae RepID=A4WJ46_PYRAR
          Length = 289

 Score =  289 bits (740), Expect = 2e-76,   Method: Composition-based stats.
 Identities = 68/294 (23%), Positives = 108/294 (36%), Gaps = 15/294 (5%)

Query: 45  EALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAKGVLPT 104
           E +   A++A   AS               H  E  +  +      L+N E++    +  
Sbjct: 4   EVILKAAKEAIVRASIG-PAFDVVSALRTAHGVEEKDAARVQLGAILKNIEMSTTEKIAV 62

Query: 105 CQDTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEVNTGTNL 164
           CQDTG      K G R     G  + L++ V     E  LR +     D  +  N G N 
Sbjct: 63  CQDTGFPNFFIKLGDRFPVRSGIYDILTRAVREVTRELPLRPNTTHPFD--ERKNPGDNT 120

Query: 165 P---AQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRTLGT 221
                  D+   DGD  +F  V KGGG+   +  +     +     L   ++E +   G 
Sbjct: 121 GMYAPWFDVELFDGDYLEFWYVPKGGGTELPSKAFTLPPGVALKE-LPRLVLEAVVDAGP 179

Query: 222 AACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLEEAQ 281
             CPP  +   +G +                                  ++E+ELL+   
Sbjct: 180 MPCPPVIVGIGVGPSVDIAAKL-------AKKAATLRPVGSRHPEPEIAKMEEELLKAIN 232

Query: 282 KLGLGA-QFGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINREGIW 334
           KLGLG    GG+  A D+ +    RH A+  +G+  SC A R   A++  +G +
Sbjct: 233 KLGLGPHGVGGRVTALDVHIEYAYRHPATFSIGIVFSCWATRRAGARVYPDGRY 286


>UniRef50_A0B6L8 Fumarase alpha subunit n=1 Tax=Methanosaeta thermophila PT
           RepID=A0B6L8_METTP
          Length = 271

 Score =  287 bits (735), Expect = 6e-76,   Method: Composition-based stats.
 Identities = 70/294 (23%), Positives = 109/294 (37%), Gaps = 27/294 (9%)

Query: 47  LTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAKGVLPTCQ 106
           +    +     +   L     + +       E SE  +Y     L N  IA     P CQ
Sbjct: 1   MVKATEAVACKSQISLPGWVVR-LIENALRSERSEIARYHLNAILNNIRIAEADARPVCQ 59

Query: 107 DTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEVNTGTNLPA 166
           DTG  +   + G+         E +++GV     +  LR +     D    +NTG N   
Sbjct: 60  DTGLPVFHVEIGEGCSFDFNLWEAIAEGVTIATRKGMLRSNVV---DPLSRLNTGDNTGP 116

Query: 167 QIDLYAVD---GDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRTLGTAA 223
            +    VD   GD  +     KG GS N ++L     A         +++E +    + A
Sbjct: 117 GMPYLIVDHVTGDSLRITAFPKGAGSENMSFLGMLNPADDPF----EYILENLAERVSNA 172

Query: 224 CPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLEEAQKL 283
           CPP  +   IGGT  +       LA                    + + E  LL+    L
Sbjct: 173 CPPVFVGIGIGGTFDQ----AAALAKRAII-----------GLPGESKEELLLLKRINDL 217

Query: 284 GLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINREGIWIE 336
           G+G    GG   A  +++ R   H AS PV + + C A+R   A++  +G  IE
Sbjct: 218 GIGPMGLGGDTTALGVKIERAFCHTASLPVAVNLQCWANRRATARVTEDGWSIE 271


>UniRef50_B0VIF1 Tartrate dehydratase alpha subunit (TtdA)/Fumarate hydratase class
           I,alpha chain (N-terminal) n=1 Tax=Candidatus
           Cloacamonas acidaminovorans RepID=B0VIF1_9BACT
          Length = 283

 Score =  287 bits (734), Expect = 8e-76,   Method: Composition-based stats.
 Identities = 85/293 (29%), Positives = 126/293 (43%), Gaps = 13/293 (4%)

Query: 38  TILKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIA 97
               V  E +      A    +F   P     +       E SE  K +    L+N E+A
Sbjct: 2   AYRYVSHETIRSELANALKHITFNPDPE-LPALLKSALANETSEISKDILKCMLKNIELA 60

Query: 98  AKGVLPTCQDTGTAIIVGKKGQRVWTGG-GDEETLSKGVYNTYIEDNLRYSQNAALDMYK 156
            K  +P CQDTG+ ++  + G      G    E +++ +  T  E  LR S      + +
Sbjct: 61  PKIEIPLCQDTGSLVVFAEIGNHCIINGPPLPEIINETLIKTSAELYLRPSILK-DPLLQ 119

Query: 157 EVNTGTNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKM 216
             NTG N PA I +  V+GD+ K     KGGG+ N + L   T +      +KNF+VE +
Sbjct: 120 RENTGNNAPAVIHISIVEGDKLKLQIAQKGGGAENMSQLKMFTPSAKVDA-IKNFVVETV 178

Query: 217 RTLGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQEL 276
                 ACPP  I   IGG      L    LA    +  L  +        +   LEQE+
Sbjct: 179 TLAKGNACPPLIIGIGIGGNFETCAL----LAKKALFQTLTAK----NPIEQYAILEQEI 230

Query: 277 LEEAQKLGLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKI 328
           L+   + G+G Q  GGK  A  + ++  P H AS PV + + C + R+I+  I
Sbjct: 231 LKSVNETGIGVQGLGGKTTALAVHILNAPCHIASLPVAVNLQCHSHRHIEIVI 283


>UniRef50_B5YEU7 Fumarate hydratase n=1 Tax=Dictyoglomus thermophilum H-6-12
           RepID=B5YEU7_DICT6
          Length = 280

 Score =  279 bits (714), Expect = 2e-73,   Method: Composition-based stats.
 Identities = 71/290 (24%), Positives = 120/290 (41%), Gaps = 13/290 (4%)

Query: 40  LKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAK 99
             +  E +     +   + +F L    +  +       E ++N + V    + NS+IA +
Sbjct: 3   RVITQEEIYKELVKLIEEINFSLPKDVESALVE-ARKKEDNKNAQIVLDILIENSKIAKE 61

Query: 100 GVLPTCQDTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEVN 159
             LP CQD G  +   + G+ +   G  E+ ++  V   Y+ D LR S     D  + +N
Sbjct: 62  KKLPLCQDCGMVVAFVEIGRELCISGSIEDVINNAVRTVYVNDFLRKSVVK--DPLRRIN 119

Query: 160 TGTNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRTL 219
           T  N PA I    V+G++ +   + KG GS N + +       ++  +L + +V+ +R  
Sbjct: 120 TEDNTPAVIHYDIVNGNKLRIYVLIKGFGSENASAVKNLLP-TISREELMDEIVDHVRLF 178

Query: 220 GTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLEE 279
           G  ACPP  +   IGGT  +  + + K         L     EH Q       E +LLE 
Sbjct: 179 GPNACPPLIVGVGIGGTLEKAAILSKKA--------LLRPIGEHNQDPFWASFEDDLLER 230

Query: 280 AQK-LGLGAQFGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKI 328
                      GGK  A  + V   P H A   + + + C A R+   ++
Sbjct: 231 INALGIGPGGLGGKTTALAVNVEIYPVHIAGFTLAISLQCCAVRHGWIEL 280


>UniRef50_B0EPH7 Serine acetyltransferase, putative n=10 Tax=cellular organisms
           RepID=B0EPH7_ENTDI
          Length = 523

 Score =  274 bits (702), Expect = 5e-72,   Method: Composition-based stats.
 Identities = 142/249 (57%), Positives = 189/249 (75%), Gaps = 11/249 (4%)

Query: 298 IRVIRLPRHGASCPV------GMGVSCSADRNIKAKINREGIWIEKLEHNPGQYIPQELR 351
           + +   P H     V      G+ +SCSADRNIK KI ++GI++E+LEHNP QY+    R
Sbjct: 266 VYISEHPTH----FVKPCANKGVKISCSADRNIKGKITKDGIFVEELEHNPEQYLCGLTR 321

Query: 352 QAGEGEAVKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELP 411
              + E  +++L+ PM EIL QL+  PV + + L+GTIIV RDIAHA++ +++    ++P
Sbjct: 322 DISK-EPTRINLDVPMPEILKQLTVLPVESPVLLSGTIIVARDIAHARINDILKETGDVP 380

Query: 412 QYIKDHPIYYAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVT 471
           QYIKDHPIYYAGPAK P GYPSGS GPTT+ RMD YVD  Q+HGGS++M+AKGNRS+ +T
Sbjct: 381 QYIKDHPIYYAGPAKQPKGYPSGSFGPTTSARMDPYVDDFQAHGGSLVMIAKGNRSEMLT 440

Query: 472 DACHKHGGFYLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKG 531
           +AC KHGGFYLG+IGG AA+LA+++IK +EC+A+ +LGMEA+WKI+VED  AF+LVDDKG
Sbjct: 441 NACKKHGGFYLGAIGGAAALLAEKNIKSVECIAFEDLGMEAVWKIKVEDLLAFVLVDDKG 500

Query: 532 NDFFQQIVN 540
           NDFF+QI  
Sbjct: 501 NDFFKQIKP 509


>UniRef50_C9KL20 L(+)-tartrate dehydratase subunit alpha n=1 Tax=Mitsuokella
           multacida DSM 20544 RepID=C9KL20_9FIRM
          Length = 299

 Score =  272 bits (697), Expect = 2e-71,   Method: Composition-based stats.
 Identities = 64/301 (21%), Positives = 106/301 (35%), Gaps = 23/301 (7%)

Query: 36  GETILKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSE 95
            E +  +  + +                P   +     L   E     K +     RN E
Sbjct: 4   EEAVRHM-TDIMAKFVAFTGKRL-----PDDVRAKIEELAKQEEEPLAKAIYQTMERNQE 57

Query: 96  IAAKGVLPTCQDTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMY 155
           +A K   P+CQDTG      K G          + L + V     +  LR++   A++ +
Sbjct: 58  LALKLNRPSCQDTGALQFFIKCGTAFPYMAELPDLLREAVVQATKDAPLRHN---AVETF 114

Query: 156 KEVNTGTNLP---AQIDLYAVDG-DEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNF 211
            E NTG N+      I      G D+ +      GGG +   +           G +  F
Sbjct: 115 DEYNTGKNVAKGIPSIFWDIAPGRDDCEIYTYMAGGGCSLPGHAKVLMPGEGYEG-VTKF 173

Query: 212 LVEKMRTLGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQ 271
           +++ M + G  ACPP  +   IG +     L++ K         L      H    +  +
Sbjct: 174 VLDVMTSYGLNACPPLLVGVGIGTSVEVAALQSKKA--------LMRRIGSHNPNPKAAK 225

Query: 272 LEQELLEEAQKLGLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINR 330
           +EQ L +    +GLG Q   GK     + +    RH +   V + V C + R      ++
Sbjct: 226 MEQLLEDGINAIGLGPQGLRGKNSVLGVNIENSARHPSVIGVAVNVGCWSHRRGHIVFDK 285

Query: 331 E 331
           E
Sbjct: 286 E 286


>UniRef50_A9BJT0 Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit
           n=9 Tax=Thermotogaceae RepID=A9BJT0_PETMO
          Length = 309

 Score =  270 bits (691), Expect = 8e-71,   Method: Composition-based stats.
 Identities = 72/297 (24%), Positives = 121/297 (40%), Gaps = 19/297 (6%)

Query: 37  ETILKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYV---ALQFLRN 93
           +T++  + E   +  ++ F   S      H  Q    ++    +  D Y    +     N
Sbjct: 26  KTVIHCKKEIGMIYKREIFEKLS-----NHIVQANETINPEVKAYIDGYSGPFSQALKEN 80

Query: 94  SEIAAKGVLPTCQDTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALD 153
            +IA    LP CQDTG        G  V        TL++ V   Y E+  R+S      
Sbjct: 81  YKIAEAEKLPLCQDTGIVEFFVFLGNEVVLEEPIFTTLNEVVEKVYAENPFRFSVVN-DP 139

Query: 154 MYKEVNTGTNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLV 213
           +++  NT  N P  + ++ + G   +   + KGGGS N + L+    ++    +LK+ ++
Sbjct: 140 LFERKNTKNNTPPVVHIFQISGKSLEIKFLVKGGGSENLSALFMLKPSI-RAQELKDVII 198

Query: 214 EKMRTLGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLE 273
             ++  G   CPP H+   IGGTS +  + + KLA    +        E  Q       E
Sbjct: 199 GHVKENGAKGCPPLHVGIGIGGTSDKAMILS-KLALTKSFK-------ERNQNPTYADFE 250

Query: 274 QELLEEAQKLGLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKIN 329
           +ELL++   L +G Q          + +   P H A+ PVG+ + C   R    K  
Sbjct: 251 EELLKDLNTLNIGFQGLKEGVSVFSVHIEYAPTHIATLPVGVSLDCYLCRKGVVKFE 307


>UniRef50_A1WMD3 Fumarase alpha subunit n=1 Tax=Verminephrobacter eiseniae EF01-2
           RepID=A1WMD3_VEREI
          Length = 290

 Score =  268 bits (686), Expect = 3e-70,   Method: Composition-based stats.
 Identities = 55/296 (18%), Positives = 103/296 (34%), Gaps = 14/296 (4%)

Query: 40  LKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAK 99
           + ++   L  +  Q +  +   + P   +   A     E     K +    L++++ A +
Sbjct: 1   MAIDSATLQRVTAQLYERSLKKI-PDDTRAALARAETAETDVTGKRMLKIMLQSADAAQQ 59

Query: 100 GVLPTCQDTGTAIIVGKKGQRVWTGGGDEETLSKG-VYNTYIEDNLRYSQNAALDMYKEV 158
                C D G  +   K G RV   G     +++G        D            ++  
Sbjct: 60  DNELVCSDVGIPVYSIKIGTRVQFEGPVRAAITRGFAELVQRSDPPILKMVTNPLTHERS 119

Query: 159 NTGTNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRT 218
           + G ++P        D D  + +C  K  G+     +       L   +++ F+++ +  
Sbjct: 120 HAGKDMPLLSFDVIDDADYVEIVCAPKAMGTGRWEAIDVFVYPTL--EQIERFILDTVLR 177

Query: 219 LGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLE 278
            G+  C P  I   IGGT         +LA                       +EQ LL+
Sbjct: 178 AGSQPCLPIVIGVGIGGTFDH----AARLAKESVLRPF----GRTNPEPILAAMEQRLLD 229

Query: 279 EAQKLGLGAQF-GGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINREGI 333
               +G G    GG   A  + +     HG   PV + ++C  +R   A+I+ +G 
Sbjct: 230 AVNAMGFGPMGTGGDASAMAVHIDYAASHG-FVPVAVCLNCWINRRTAARIHNDGR 284


>UniRef50_A8S1R3 Putative uncharacterized protein n=1 Tax=Clostridium bolteae ATCC
           BAA-613 RepID=A8S1R3_9CLOT
          Length = 299

 Score =  267 bits (684), Expect = 6e-70,   Method: Composition-based stats.
 Identities = 67/286 (23%), Positives = 108/286 (37%), Gaps = 17/286 (5%)

Query: 51  AQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAKGVLPTCQDTGT 110
             + F   S    P           + E S+  K +   +  N ++A K   P CQDTG 
Sbjct: 13  IMEKFIGMSSKRLPDDVYAKLKECGEKEDSDIQKVIYNAYFENLDMAGKLSRPCCQDTGL 72

Query: 111 AIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEVNTGTNLP---AQ 167
                K G      G   + L +  +N      LR +     + ++E NT  N       
Sbjct: 73  LHFYIKMGTGFAYQGMVADCLREATHNATYSAPLRQNTV---NYFEERNTNDNTGERMPW 129

Query: 168 IDLYAVDG-DEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRTLGTAACPP 226
           I+   V   D+ + +    GGG            +      +  ++ + +  LG  ACPP
Sbjct: 130 INWDIVPDNDDLEIITYFAGGGCCLPGRSQVFKPSDGY-AAIIRYVFDAVSDLGINACPP 188

Query: 227 YHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLEEAQKLGLG 286
             +   +G  +    L    L+   Y   L T         +  QLEQ+LLE   KLG+G
Sbjct: 189 LIVGVGLGHNAENAAL----LSKKAYLRPLGTS----HPHPKGAQLEQDLLEGLNKLGIG 240

Query: 287 AQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINRE 331
           AQ   G   A ++ +    RH A+  +G+ V+C A R    + + +
Sbjct: 241 AQGLRGNCAAMEVHIESSARHTATIAIGVNVACYAHRRGVIRFHND 286


>UniRef50_Q0TD45 L(+)-tartrate dehydratase subunit alpha n=126 Tax=Bacteria
           RepID=TTDA_ECOL5
          Length = 303

 Score =  265 bits (677), Expect = 4e-69,   Method: Composition-based stats.
 Identities = 67/315 (21%), Positives = 113/315 (35%), Gaps = 23/315 (7%)

Query: 31  VADFDGETILKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQF 90
           +++ + +  +      LT +    F        P         L D E S   K +    
Sbjct: 2   MSESNKQQAVN----KLTEIVAN-FTAMISTRMPDDVVDKLKQLKDAETSSMGKIIYHTM 56

Query: 91  LRNSEIAAKGVLPTCQDTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNA 150
             N + A     P CQDTG  +   K G R    G  +  L + V    ++  LR++   
Sbjct: 57  FDNMQKAIDLNRPACQDTGEIMFFVKVGSRFPLLGELQSILKQAVEEATVKAPLRHN--- 113

Query: 151 ALDMYKEVNTGTNLPAQIDLYAV----DGDEYKFLCVAKGGGSANKTYLYQETKALLTPG 206
           A++++ EVNTG N  + +         D D+ +      GGG            +    G
Sbjct: 114 AVEIFDEVNTGKNTGSGVPWVTWDIIPDNDDAEIEVYMAGGGCTLPGRSKVLMPSEGYEG 173

Query: 207 KLKNFLVEKMRTLGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQA 266
            +K F+ E + TL   ACPP  +   I  +     + + K         +          
Sbjct: 174 VVK-FVFENISTLAVNACPPVLVGVGIATSVETAAVLSRKA--------ILRPIGSRHPN 224

Query: 267 FRDVQLEQELLEEAQKLGLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIK 325
            +  +LE  L E   +LG+G Q   G      + +    RH ++  V +   C A R   
Sbjct: 225 PKAAELELRLEEGLNRLGIGPQGLTGNSSVMGVHIESAARHPSTIGVAVSTGCWAHRRGT 284

Query: 326 AKINREGIWIEKLEH 340
             ++ + +  E L H
Sbjct: 285 LLVHAD-LTFENLSH 298


>UniRef50_C7IGU6 Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit
           n=2 Tax=Clostridium RepID=C7IGU6_9CLOT
          Length = 291

 Score =  262 bits (670), Expect = 2e-68,   Method: Composition-based stats.
 Identities = 64/298 (21%), Positives = 105/298 (35%), Gaps = 20/298 (6%)

Query: 49  LLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAKGVLPTCQDT 108
            + +      S+ +     + +     + E  E+ K +    + N  IA +     CQ  
Sbjct: 5   QVLRDLIFKISYEVS-DDCRCLLNKAVEIETDESSKMILETIIENVSIARECKQALCQSP 63

Query: 109 GTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEVNTGTNLP--- 165
           G        G   +     E+ L + V +      LR S     D    VN+G N     
Sbjct: 64  GYLTTYVTFGDDFFIS-DLEQILKEAVIDATKAGYLRPSMV---DPLTRVNSGDNSGRGV 119

Query: 166 AQIDLYAVDG-DEYKFLCVAKGGGSA--NKTYLYQETKALLTPGKLKNFLVEKMRTLGTA 222
             ++     G D  + +   KG G    NK  ++   +       +K F++E +   G  
Sbjct: 120 PNMEYEYKKGIDYIEIIPSIKGCGIELYNKVKVFTIAEIGDNFEGIKKFVLECVVEAGGT 179

Query: 223 ACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLEEAQK 282
           AC P  I   IGG        + +  S   +        +  +  R  QLE ELLE    
Sbjct: 180 ACLPSAIGIGIGGQLDVAAKLSRRAMSLRGW-------MQRSEDKRLAQLEDELLEAINS 232

Query: 283 LGLG-AQFGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINREGIWIEKLE 339
           L +G    GGK     + +     H   CPV +   C   R    +I ++G  +E+L 
Sbjct: 233 LNIGSGGTGGKVTTLGVNIETAATHTTLCPVAINFHCWVARRAGIRIYKDGR-VEELS 289


>UniRef50_A7HKF1 Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit
           n=1 Tax=Fervidobacterium nodosum Rt17-B1
           RepID=A7HKF1_FERNB
          Length = 277

 Score =  256 bits (655), Expect = 1e-66,   Method: Composition-based stats.
 Identities = 70/294 (23%), Positives = 124/294 (42%), Gaps = 18/294 (6%)

Query: 39  ILKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAA 98
           ++K++ + +     +   + +  ++P                   K      + N EIA+
Sbjct: 1   MVKIKSDVVFEKISEVLIEINTKIKPE-----IKEFFKDYEGPFKKE----IIENFEIAS 51

Query: 99  KGVLPTCQDTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEV 158
           K  LP CQDTG       KG  V      E  L + V + Y     R S  +   ++  V
Sbjct: 52  KEYLPLCQDTGMVEFFVFKGFNVLLDKPIEYILDEAVKDVYERFGFRKSVVS-DPLFSRV 110

Query: 159 NTGTNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRT 218
           NT TN P  + L+ ++ ++ +   +AKGGGS N + LY    +      +   + E ++ 
Sbjct: 111 NTRTNTPCVVHLFEIEENKLEIWTIAKGGGSENLSALYMFNPSESYEA-ISQKIFEHIKQ 169

Query: 219 LGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLE 278
            G  ACPP  +   +GGTS +  + + KLA   Y   +  +        R  + E++L+E
Sbjct: 170 NGPNACPPIKVGVGVGGTSDKAVMLS-KLALFDYDASVYLK-----NVIRYQKAEEKLME 223

Query: 279 EAQKLGLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINRE 331
              ++  G Q  G     +++++   P H A+ PV + V C   R+ +     E
Sbjct: 224 RLNEIKFGVQGLGYGKGIYNVKMYGFPTHIATLPVAISVDCYLLRSGRVVFENE 277


>UniRef50_Q8U062 Possible fumarate hydratase (Fumarase) alpha subunit n=4
           Tax=Thermococcaceae RepID=Q8U062_PYRFU
          Length = 272

 Score =  255 bits (652), Expect = 3e-66,   Method: Composition-based stats.
 Identities = 69/286 (24%), Positives = 114/286 (39%), Gaps = 21/286 (7%)

Query: 48  TLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAKGVLPTCQD 107
                +A   A   L P          ++ E  E  KY     LR  + + K  +P CQD
Sbjct: 1   MEDIVEALKLAVTNL-PEDVALALKNAYEREDYEIAKYNLEIMLRAVKTSKKEKVPLCQD 59

Query: 108 TGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEVNTGTNLPAQ 167
           TGT I   +     W      ET+++ V     E  LR +   A+ +      G N+P  
Sbjct: 60  TGTPIFFVET-DGTWNVKEIYETIAEAVKRATDEIPLRPN---AICLLSGKVVG-NVP-- 112

Query: 168 IDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRTLGTAACPPY 227
            +++   G   +   + KGGGS N + L+  T      G +K  +++ +R+ G   CPP 
Sbjct: 113 -EIHIEPGKRNRISILIKGGGSENCSALFPLTPGDWFEG-VKKKIIDHIRSCGGKPCPPI 170

Query: 228 HIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLEEAQKLGLGA 287
            +   I    A    + + LA    + ++     + G    ++  E   L+      +G 
Sbjct: 171 IVGIGI----ASPAERAITLAKKSLFRKIGERHEKLGWLEEEILEEINFLD------IGP 220

Query: 288 Q-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINREG 332
              GGK  A D+++    RH AS  VG+ + C A R    +   +G
Sbjct: 221 MGLGGKTTALDVKIEVGERHPASFIVGIAIQCWAHRRAFIEEKEDG 266


>UniRef50_C8WG72 Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit
           n=2 Tax=Coriobacteriaceae RepID=C8WG72_EGGLE
          Length = 354

 Score =  251 bits (640), Expect = 7e-65,   Method: Composition-based stats.
 Identities = 77/289 (26%), Positives = 114/289 (39%), Gaps = 13/289 (4%)

Query: 42  VEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAKGV 101
           +    +      A    + +L PA  +   A+  + E +   + V  Q + N+ IAA+  
Sbjct: 5   ITKSQVADAVYAAIPKLACVL-PADIEAGLAVARELEGNPRGRAVLDQLIENAAIAAEDR 63

Query: 102 LPTCQDTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEVNTG 161
           +P CQDTGT  +  + G  V   G     +   V   Y E  LR S      +    NTG
Sbjct: 64  VPICQDTGTVWVSLEIGPDVAVRGDVFADVDDAVARAYDEARLRKSVV-RDAVLDRANTG 122

Query: 162 TNLPAQIDLYAVDGDE-YKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRTLG 220
            N PA  D++ VD     +   + KGGGS N + +          G + + LV  +R  G
Sbjct: 123 DNTPAFCDVHPVDEPGAARLHVMLKGGGSDNASRVVMLVPGAGKQG-IVDELVRCVREKG 181

Query: 221 TAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLEEA 280
             ACPP  +   IG T  +                L    +E     R   LE+ELL   
Sbjct: 182 ANACPPLVVGVGIGSTFDKVAGLAK--------RALMRPVDEPAADDRLRALEEELLAAV 233

Query: 281 QKL-GLGAQFGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKI 328
                     GG+  A  +RV   P H A+ P+ + + CSA R I   +
Sbjct: 234 NATGIGPGGLGGRTTALAVRVATAPCHIAALPLAINMGCSAMRRITVPL 282


>UniRef50_Q3IXH2 Fumarase alpha subunit n=14 Tax=Proteobacteria RepID=Q3IXH2_RHOS4
          Length = 320

 Score =  245 bits (626), Expect = 3e-63,   Method: Composition-based stats.
 Identities = 63/323 (19%), Positives = 104/323 (32%), Gaps = 24/323 (7%)

Query: 42  VEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAKGV 101
           +  + +   A++    A+  + P             E  +   +V    L N E A +  
Sbjct: 2   ISLDLIQRTAERLMEKAAIEI-PEDYLDGLKATAAVEDGDLSSFVLQAMLENYEAAKEDR 60

Query: 102 LPTCQDTGTAIIVGKKGQRVWTGGG---DEETLSKGVYNTYIEDNLRYSQNAALDMYKEV 158
              C DTG      K G      GG    E  L +       +  LR ++   L      
Sbjct: 61  RAMCGDTGCPRWYVKMGNEAHIEGGPIALEAALRRATARATHDIPLRPNRVHPLWRTDHD 120

Query: 159 -NTGTNLPAQIDLYAVDGDEYKFLCVAKGG--GSANKTYLYQETKALLTPGKLKNFLVEK 215
            N G   P     +   GD    + V KGG  G+           +    G ++ F ++ 
Sbjct: 121 NNVGIGAPEIEYGFEPGGDWIDLITVHKGGLFGTDY----RMLFPSDGIQG-IRRFFLDS 175

Query: 216 MRTLG--TAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLE 273
           +   G    AC P  I   +GG+     +   + A                   R   LE
Sbjct: 176 LVAFGKRGLACQPAIIGIGLGGSKDACMVLGKRAA-------CLRTVGSRNSDPRIAALE 228

Query: 274 QELLEEAQKLGLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINREG 332
            EL E    +G+GA  F GK    D  +     H     + +   C + R   A++  +G
Sbjct: 229 GELKELGNSIGMGAMGFVGKSMVVDCNIEVGYCHTGGMQMSVHAFCLSSRRAVARLWGDG 288

Query: 333 IWIEKLEHNPGQYIPQELRQAGE 355
               +   +P  +   + R+  E
Sbjct: 289 R--VEYRTDPDWFTDYQRRETVE 309


>UniRef50_A6TTM2 Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit
           n=22 Tax=cellular organisms RepID=A6TTM2_ALKMQ
          Length = 185

 Score =  245 bits (626), Expect = 3e-63,   Method: Composition-based stats.
 Identities = 67/189 (35%), Positives = 102/189 (53%), Gaps = 4/189 (2%)

Query: 359 VKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHP 418
           +   +  P+     ++        + LTG I   RD AH +L +L++AG++LP  ++D  
Sbjct: 1   MSKKITMPLT--AEKVKSLKAGDSVLLTGMIYTARDAAHKRLVDLLEAGEDLPIELQDQV 58

Query: 419 IYYAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHG 478
           IYY GP     G P GS GPTT+ RMDSY   L    G   M+ KG R + V  A  + G
Sbjct: 59  IYYVGPTPAKEGQPIGSAGPTTSYRMDSYTPALLEQ-GLKGMIGKGLRGESVITAIKQQG 117

Query: 479 GFYLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQI 538
             Y  +IGG +A++A + +K  E +AY +LG EAI K+ VED P  +++D KGN++++  
Sbjct: 118 AVYFAAIGGASALMA-KCVKSAEIIAYEDLGAEAIRKLYVEDLPLIVVIDAKGNNYYEIG 176

Query: 539 VNKQCANCT 547
             +      
Sbjct: 177 QEEYLKTLR 185


>UniRef50_Q2RG70 Hydro-lyases, Fe-S type, tartrate/fumarate subfamily, beta region
           n=69 Tax=Bacteria RepID=Q2RG70_MOOTA
          Length = 219

 Score =  245 bits (625), Expect = 4e-63,   Method: Composition-based stats.
 Identities = 70/196 (35%), Positives = 103/196 (52%), Gaps = 4/196 (2%)

Query: 347 PQELRQAGEGEAVKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDA 406
           P    +      ++  L+ P+   +  +       R+ ++G I   RD AH +L EL+D 
Sbjct: 22  PAGDNRRTGDSPIR-HLHTPLS--VDDVESLRAGDRVLISGVIYAARDSAHKRLVELLDR 78

Query: 407 GKELPQYIKDHPIYYAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNR 466
           G+ELP  +K   IYY GP     G  +G+ GPTT+GRMD Y   L +  G   M+ KG R
Sbjct: 79  GEELPVDLKGQVIYYVGPTPARPGRVTGAAGPTTSGRMDPYTPRLIAATGLKGMIGKGFR 138

Query: 467 SQQVTDACHKHGGFYLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFIL 526
           S +V  A   H   Y  ++GG  A++A + IK  E VAYPELG EA+  +EVED P  ++
Sbjct: 139 SPEVKKALVDHKAVYFAAVGGAGALIA-RCIKKAEIVAYPELGPEALRALEVEDLPVTVI 197

Query: 527 VDDKGNDFFQQIVNKQ 542
            D  G D + + + + 
Sbjct: 198 NDCYGGDLYTEALARY 213


>UniRef50_C1SNL0 Hydro-lyase, Fe-S type, tartrate/fumarate subfamily n=1
           Tax=Denitrovibrio acetiphilus DSM 12809
           RepID=C1SNL0_9BACT
          Length = 288

 Score =  244 bits (622), Expect = 9e-63,   Method: Composition-based stats.
 Identities = 63/296 (21%), Positives = 110/296 (37%), Gaps = 20/296 (6%)

Query: 47  LTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAKGVLPTCQ 106
           L     +    A+  L P  +  +       +     K V      N  +A +   P CQ
Sbjct: 3   LKDAMLELIRRATTDLSPDVENAIQQAYDREDEGTPAKSVFGTIRENIALAREASTPICQ 62

Query: 107 DTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEVNTGTNLP- 165
           DTG+ II          G  + +      +       L+Y +  A+D     N+G N+  
Sbjct: 63  DTGSVIIYI----DFPVGEPETKYKEAAEWAAAEATKLQYLRPNAVDPITGKNSGNNVGT 118

Query: 166 --AQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGK----LKNFLVEKMRTL 219
               +  +  D DE +   + KGGGS N    Y+   ++L  G+    +K  +++ ++  
Sbjct: 119 NAPYLHFHQWDKDETRVRLMLKGGGSENVGAQYKLPDSVLHAGRDLKGVKKVVIDAVQKA 178

Query: 220 GTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLEE 279
               C P  +            + +  L+   ++ +L     E        +LE+EL E+
Sbjct: 179 QGQGCAPGVVG----IGIGGDRVTSYALSKEQFFRKL----GEKSTNPDLAKLEEELYED 230

Query: 280 AQKLGLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINREGIW 334
             KLG+G   FGGK     +      RH A+  V +  +C A R  +  I    + 
Sbjct: 231 LNKLGIGPMGFGGKTTCLGVFAGVQHRHPATFYVAISYTCWAYRRKQMTIKGSEVT 286


>UniRef50_C3PJK7 Tartrate dehydratase n=18 Tax=Bacteria RepID=C3PJK7_CORA7
          Length = 344

 Score =  239 bits (611), Expect = 2e-61,   Method: Composition-based stats.
 Identities = 64/297 (21%), Positives = 102/297 (34%), Gaps = 18/297 (6%)

Query: 41  KVEPEALTLLAQQA-FHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAK 99
           +  PE   L+ + A F D      P    +    L + E     K +     RN ++A  
Sbjct: 47  QFSPEVQLLIDRVAKFTDLVSKRLPDDVTERLRQLAEEEDQPMAKMIYKTMQRNQKLALD 106

Query: 100 GVLPTCQDTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEVN 159
              P+CQDTG   I  + G         E  + + +        LR +     + + E N
Sbjct: 107 LDRPSCQDTGQIQIFARVGTEFPYLSELEPAMKEAIGIASETAPLRRNSV---ETFNEYN 163

Query: 160 TGTNLP---AQIDLYAVDG-DEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEK 215
            GTN+      +    + G DE +      GGG +                 +K F+++ 
Sbjct: 164 PGTNIGTKSPWLYTELISGSDELELDVYLAGGGCSLPGQGKTLMPGEGYEAAMK-FILDV 222

Query: 216 MRTLGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQE 275
           M + G  ACPP  I   IG +       + KLA       L      H Q     +LE+ 
Sbjct: 223 MTSYGVNACPPMLIGVGIGTSIDTAGFMS-KLA-------LMRPVQSHNQNEVVAELEKN 274

Query: 276 LLEEAQK-LGLGAQFGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINRE 331
           L              GGK     + +    RH +   V +   C + R     ++R+
Sbjct: 275 LETAINDLGLGPQGLGGKRSVMGVNIENSARHPSVLSVAVNTGCWSHRRGTIHLDRD 331


>UniRef50_B8I5L5 Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit
           n=8 Tax=Bacteria RepID=B8I5L5_CLOCE
          Length = 185

 Score =  237 bits (606), Expect = 5e-61,   Method: Composition-based stats.
 Identities = 68/182 (37%), Positives = 101/182 (55%), Gaps = 4/182 (2%)

Query: 363 LNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHPIYYA 422
           L  P     A+L        +SL+GTI   RD AH K+ EL+   +ELP  + +  IYY 
Sbjct: 5   LTAPFDRDKARL--LKAGDTVSLSGTIYTARDAAHKKMIELLQENRELPFDMSNQTIYYV 62

Query: 423 GPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHGGFYL 482
           GP  +  G   GS GPT++ RMD+Y   L    G   M+ KG R Q V +A  ++G  YL
Sbjct: 63  GPCPSREGEIIGSAGPTSSYRMDAYAPTLIRL-GETAMIGKGLRDQNVINAMKEYGAVYL 121

Query: 483 GSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQIVNKQ 542
           G+IGG  A++A+  IK  E +A+PELG EA+  +E+ +FP  +++D  GN+ ++    + 
Sbjct: 122 GAIGGAGALMAE-CIKRQEIIAFPELGAEAVRHLEIINFPLIVVIDSHGNNLYESGRKQY 180

Query: 543 CA 544
             
Sbjct: 181 RK 182


>UniRef50_Q58034 Putative fumarate hydratase subunit beta n=13 Tax=Euryarchaeota
           RepID=FUMB_METJA
          Length = 195

 Score =  236 bits (601), Expect = 2e-60,   Method: Composition-based stats.
 Identities = 50/183 (27%), Positives = 87/183 (47%), Gaps = 4/183 (2%)

Query: 370 ILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHPIYYAGPAKTP- 428
               + +  V   + L G I   RD AH K+ E++ + ++LP  + +  IY+AGP     
Sbjct: 9   TKKDVKKLKVGDIVYLNGKIYTARDEAHLKIIEMLKSNEKLPFDLNESIIYHAGPIMKKV 68

Query: 429 -AGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHGGFYLGSIGG 487
              +   S+GPTT+ RM+   +          ++ KG   +++      +G  YL + GG
Sbjct: 69  NDSWVCVSIGPTTSARMNDVEEEFIKLTNISAIVGKGGMKKELLKTFEDYGVVYLAAPGG 128

Query: 488 PAAVLAQQSIKHLECVAYPELGM-EAIWKIEVEDF-PAFILVDDKGNDFFQQIVNKQCAN 545
            AA+LA    +        ELGM EA+W++EV +F P  + +D  GN  ++++  K    
Sbjct: 129 CAALLANSVKRVDNVYFLDELGMPEAVWELEVNNFGPLIVAMDSHGNSIYEEVNKKVYEK 188

Query: 546 CTK 548
             +
Sbjct: 189 LNE 191


>UniRef50_D1SM64 Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit
           n=1 Tax=Methanocaldococcus sp. FS406-22
           RepID=D1SM64_9EURY
          Length = 218

 Score =  234 bits (597), Expect = 7e-60,   Method: Composition-based stats.
 Identities = 57/201 (28%), Positives = 94/201 (46%), Gaps = 7/201 (3%)

Query: 352 QAGEGEAVKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELP 411
           +  EGE ++   N   K     + +  V   + L G I   RD AH K+ E+I   ++LP
Sbjct: 17  KTIEGENLEYTFN---KLTKRDVKKLRVGDIVYLNGKIYTARDEAHLKIIEMIKNKEKLP 73

Query: 412 QYIKDHPIYYAGPAKTP--AGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQ 469
             + +  IY+AGP        +   S+GPTT+ RM+   +          ++ KG   ++
Sbjct: 74  FDLNEAIIYHAGPIMKKVNDNWTCISIGPTTSARMNDVEEEFIKLTNISAIVGKGGMKKE 133

Query: 470 VTDACHKHGGFYLGSIGGPAAVLAQQSIKHLECVAYPELGM-EAIWKIEVEDF-PAFILV 527
           +       G  YL + GG AA+LA    K        ELGM EA+W++EV++F P  + +
Sbjct: 134 LLKTFEDFGVVYLAAPGGCAALLANSVKKVNNVYFLEELGMPEAVWELEVDNFGPLIVAM 193

Query: 528 DDKGNDFFQQIVNKQCANCTK 548
           D  GN  ++++  K      +
Sbjct: 194 DCFGNSIYEEVNKKVYEKLNE 214


>UniRef50_A4XHH2 Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit
           n=2 Tax=Clostridia RepID=A4XHH2_CALS8
          Length = 204

 Score =  234 bits (596), Expect = 8e-60,   Method: Composition-based stats.
 Identities = 65/190 (34%), Positives = 100/190 (52%), Gaps = 3/190 (1%)

Query: 357 EAVKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKD 416
           E     L  P+     ++  + V   + ++G + V RD AH +L ++   G+++P   K+
Sbjct: 17  EQKLKRLYIPVTNE-EEIKSFKVGQEVLVSGRLFVARDAAHKRLIDMFKRGEDIPIDFKN 75

Query: 417 HPIYYAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHK 476
             IYY GP     G   G  GPTTAGRMD +  ++    G  +++ KG RS QV +A   
Sbjct: 76  GAIYYMGPCPEKPGEVIGPCGPTTAGRMDIFTPIVLKL-GVKVLIGKGKRSPQVKEAIKS 134

Query: 477 HGGFYLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQ 536
           +G  YL + GG AA+L Q  +K  + + + +LG EAI +IEVED P  + VD +G D ++
Sbjct: 135 YGAIYLATFGG-AAILIQSCVKSQKILMFEDLGPEAIREIEVEDLPCVVAVDSQGEDIYE 193

Query: 537 QIVNKQCANC 546
               K   N 
Sbjct: 194 IGPRKYARNL 203


>UniRef50_C4GCC8 Putative uncharacterized protein n=1 Tax=Shuttleworthia satelles
           DSM 14600 RepID=C4GCC8_9FIRM
          Length = 197

 Score =  233 bits (594), Expect = 2e-59,   Method: Composition-based stats.
 Identities = 67/186 (36%), Positives = 101/186 (54%), Gaps = 4/186 (2%)

Query: 360 KVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHPI 419
           ++ +  P+++ +  + +      + L G + V RD AH +L +LI AGK+LP  ++   I
Sbjct: 3   EIKIRLPLRDEV--IEKLRAGDYVYLKGDLYVARDAAHKRLMDLIKAGKKLPISLEGETI 60

Query: 420 YYAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHGG 479
           YY GP+    G   GS GPTTA RMD Y   L    G   M+ KG RS +V DA  +   
Sbjct: 61  YYMGPSPAREGQVIGSAGPTTASRMDKYTPTLLDL-GLKGMVGKGKRSSEVLDAIVRDHA 119

Query: 480 FYLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQIV 539
            Y  ++GG  A+L+ + I+  E V Y +LG EAI +I VE  P  +L+D KGN+ ++   
Sbjct: 120 IYFAAVGGAGALLS-KCIRKSEIVCYEDLGAEAIRRITVEALPLVVLIDCKGNNLYEAAS 178

Query: 540 NKQCAN 545
            +   N
Sbjct: 179 REYADN 184


>UniRef50_Q469V5 Fumarase beta subunit n=10 Tax=Archaea RepID=Q469V5_METBF
          Length = 191

 Score =  225 bits (575), Expect = 2e-57,   Method: Composition-based stats.
 Identities = 62/194 (31%), Positives = 97/194 (50%), Gaps = 9/194 (4%)

Query: 359 VKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHP 418
           ++  L  P+K+    + +      + ++G I+  RD AHA++ E+ +  +ELP  ++   
Sbjct: 1   MEYHLKTPLKK--EDIEKLNAGDIVYISGEILTARDEAHARILEMGEKKEELPFSLEGAV 58

Query: 419 IYYAGPAKTP--AGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHK 476
           IY+ GP       G+   S GPTT+GRM      L        ++ KG     V DA   
Sbjct: 59  IYHCGPLMQKTENGWKVVSAGPTTSGRMSKMTPPLLKAHDVRAIIGKGGMKD-VADALK- 116

Query: 477 HGGFYLGSIGGPAAVLAQQSIKHLECVAYPELGM-EAIWKIEVEDF-PAFILVDDKGNDF 534
           +G  YL   GG AA LA + IK ++ V + +LGM EA+W + VE+F P  + +D KG D 
Sbjct: 117 NGSVYLAYTGGCAA-LAAELIKEVKAVHWLDLGMPEAVWVLRVEEFGPLIVGIDTKGKDI 175

Query: 535 FQQIVNKQCANCTK 548
           F ++  K      K
Sbjct: 176 FAEVREKAQKQLEK 189


>UniRef50_A1RT45 Fumarase beta subunit n=8 Tax=Thermoprotei RepID=A1RT45_PYRIL
          Length = 211

 Score =  225 bits (574), Expect = 3e-57,   Method: Composition-based stats.
 Identities = 56/190 (29%), Positives = 102/190 (53%), Gaps = 7/190 (3%)

Query: 363 LNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHPIYYA 422
           L  P+      +++  +   + ++G I+  RD AH ++ E ++ G++LP  +K   IY+A
Sbjct: 16  LKTPLS--TEDIAKLRIGDTVYISGVIVSARDSAHKRMLEYVERGEKLPVDLKGGVIYHA 73

Query: 423 GPA--KTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHGGF 480
           GP   KT  G+   S+GPTT+ RM+++   +    G  +++ KG   ++  +A  KH   
Sbjct: 74  GPVAKKTDRGWEIISMGPTTSARMETFEADVIEKLGVKLVVGKGGMGKRTAEAMKKHVAA 133

Query: 481 YLGSIGGPAAVLAQQSIKHLECVAYPELG-MEAIWKIEVEDF-PAFILVDDKGNDFFQQI 538
           Y    GG   VLA ++IK +  V + +LG  EA+W +EVE+F P  I++D  G +++ + 
Sbjct: 134 YAIFTGGAG-VLAAKAIKRVIDVYWLDLGIAEAMWVLEVENFGPLTIMIDPTGRNYYDEQ 192

Query: 539 VNKQCANCTK 548
             +      +
Sbjct: 193 REEARRRVPE 202


>UniRef50_UPI0001C35B8B hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit
           n=1 Tax=Clostridium hathewayi DSM 13479
           RepID=UPI0001C35B8B
          Length = 288

 Score =  222 bits (567), Expect = 2e-56,   Method: Composition-based stats.
 Identities = 47/293 (16%), Positives = 91/293 (31%), Gaps = 26/293 (8%)

Query: 46  ALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAKGVLPTC 105
            +T    Q   DAS   R   Q          E   + K+    F++N+ +A K     C
Sbjct: 6   KVTEDVAQTVVDASSHWR-DDQVACWKQACAEEEIPHAKWAMENFIKNAAVADKKHCALC 64

Query: 106 QDTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEVNTGTNL- 164
            DTGT     + G       G    +  G+     +   R       D  + ++    L 
Sbjct: 65  DDTGTPHPFLEIGDEAVLPAGFLAAMEDGIRKGLNDLPARPMGVRG-DELERISQCKGLY 123

Query: 165 -------PAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMR 217
                  PA   +  + G   +   +  GGG   ++              ++  +   + 
Sbjct: 124 DEPGMLKPAPTQIRRMAGSRIRLTILMLGGGPEIRSRTQALFHMHSLDHVVEEMIEWAVP 183

Query: 218 TLGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELL 277
            +    C P  ++F +G T+ E +  +++      YD                ++E+ + 
Sbjct: 184 QVAALGCQPCTLSFGLGRTAVEASSLSLEAMKDGCYDV-------------QSEMEKRIT 230

Query: 278 EEAQKLGLGA-QFGGKYFAHDIRVIRLPRHGASC-PVGMGVSCSAD-RNIKAK 327
           +     G+G    GG        +       +    V M  +C  + R    +
Sbjct: 231 DAVNGKGIGPIGLGGASSVLATFIKIGDMRASGFRVVSMRPNCCMEIRKASCE 283


>UniRef50_D1BP97 Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit
           n=5 Tax=Veillonellaceae RepID=D1BP97_VEIPT
          Length = 186

 Score =  222 bits (565), Expect = 3e-56,   Method: Composition-based stats.
 Identities = 66/188 (35%), Positives = 103/188 (54%), Gaps = 5/188 (2%)

Query: 358 AVKVDLNRPMKEILAQL-SQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKD 416
           A  + +N   +E   +   +  V   + +TG I   RD AH  + E +  G++LP    +
Sbjct: 2   AESIRINT--EEYNEEFSRKLKVGDSVLITGKIYSARDAAHKVMTEALARGEKLPIDWTN 59

Query: 417 HPIYYAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHK 476
             +YY GP     G P GS GPTT+GRMD+Y   +    G   M+ KG+R  +V ++  K
Sbjct: 60  KFVYYLGPTPAKPGDPIGSAGPTTSGRMDAYTPTMLDQ-GIKGMIGKGSRKPEVVESMKK 118

Query: 477 HGGFYLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQ 536
           +G  Y  ++GG AA++A +SIK  E +AY ELG EA+ ++ VEDFP  ++ D +GN+F++
Sbjct: 119 NGCTYFAAVGGAAALIA-KSIKKYEVLAYGELGPEALAELTVEDFPCIVVGDTEGNNFYE 177

Query: 537 QIVNKQCA 544
                   
Sbjct: 178 LGQKPYRK 185


>UniRef50_Q1LBZ6 Hydro-lyases, Fe-S type, tartrate/fumarate subfamily, beta region
           n=3 Tax=Burkholderiales RepID=Q1LBZ6_RALME
          Length = 187

 Score =  220 bits (561), Expect = 1e-55,   Method: Composition-based stats.
 Identities = 57/186 (30%), Positives = 92/186 (49%), Gaps = 4/186 (2%)

Query: 362 DLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHPIYY 421
            L  P+ E    + Q  V   + L+GTI + RD AH +  + +  G+ LP  +K   ++Y
Sbjct: 5   RLTTPLTE--EAIRQLNVGDEVLLSGTIYMARDAAHKRFVDTLARGEPLPVDLKGQVVFY 62

Query: 422 AGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHGGFY 481
            GP  T  G+  G + PT+A RMD Y  +L    G    + KG+R   +  +C  +    
Sbjct: 63  GGPGPTKPGHVIGVVAPTSAYRMDPYATVLF-EYGVKGAIGKGDRGDAIRASCKSNTAVC 121

Query: 482 LGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQIVNK 541
             +IGG +A L    IK  E +AY +L  EA+ ++ +EDFP  +  D +G D +++ V +
Sbjct: 122 FSAIGGISATLF-SCIKSAEIIAYEDLKTEAVQRLVIEDFPLLVTNDAQGRDMYEEEVTR 180

Query: 542 QCANCT 547
                 
Sbjct: 181 FKKLLN 186


>UniRef50_Q0W346 Fumarate hydratase (Fumarase), beta subunit n=1 Tax=uncultured
           methanogenic archaeon RC-I RepID=Q0W346_UNCMA
          Length = 194

 Score =  220 bits (560), Expect = 1e-55,   Method: Composition-based stats.
 Identities = 59/192 (30%), Positives = 95/192 (49%), Gaps = 8/192 (4%)

Query: 359 VKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHP 418
           ++  L  P+               + LTGT+I  RD AH ++ E     K LP  ++   
Sbjct: 1   MEHRLRTPVS--AETARSLHAGDTVFLTGTMITARDKAHIRMAEYFSGEKPLPFSLEGAV 58

Query: 419 IYYAGPAKT--PAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHK 476
           I++  P       G+   ++GPTT+ RM+     + +H G+ +++ KG    +   A H 
Sbjct: 59  IFHGAPIVRQKADGWEMVAIGPTTSARMNDLEPPVIAH-GARMIVGKGGMDSRTLHALHD 117

Query: 477 HGGFYLGSIGGPAAVLAQQSIKHLECVAYPELGM-EAIWKIEVEDF-PAFILVDDKGNDF 534
           HG  YL   GG AAVL  + +K +  V + +LGM EA+W +EVEDF P  + +D   +D 
Sbjct: 118 HGSVYLSMTGG-AAVLGARMVKRVAGVEWTDLGMAEAVWVLEVEDFGPLTVTMDAHLHDL 176

Query: 535 FQQIVNKQCANC 546
           +Q + N+   N 
Sbjct: 177 YQDVRNRVSENI 188


>UniRef50_B1L7M7 Tartrate dehydratase beta subunit/Fumarate hydratase class I,
           C-terminal domain protein n=1 Tax=Candidatus Korarchaeum
           cryptofilum OPF8 RepID=B1L7M7_KORCO
          Length = 199

 Score =  219 bits (559), Expect = 2e-55,   Method: Composition-based stats.
 Identities = 57/189 (30%), Positives = 94/189 (49%), Gaps = 9/189 (4%)

Query: 360 KVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKE--LPQYIKDH 417
           +  L  P+ E   Q+ +  V   + L G II GRD  H +  EL   G++  +P  ++  
Sbjct: 3   EYRLRTPVTE--EQVRKLKVGDVVYLDGIIITGRDQVHRRALELASKGEKDKVPVKLEGM 60

Query: 418 PIYYAGPA--KTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACH 475
            +Y+ GP   K    +     GPTT+ RM+S         G  +++ KG   ++ T A  
Sbjct: 61  ALYHCGPIVGKVDGEWKIYGFGPTTSARMESVEADFIREFGVRLIIGKGGLFERTTQAMK 120

Query: 476 KHGGFYLGSIGGPAAVLAQQSIKHLECVAYPELG-MEAIWKIEVEDF-PAFILVDDKGND 533
           ++G  YL   GG  +VLA  ++K +  V + +LG  EA+W +EVE+F P  + +D  GN+
Sbjct: 121 EYGAAYLAYPGG-VSVLATNAVKRVVDVHWLDLGVPEAMWVVEVENFGPTMVAIDSHGNN 179

Query: 534 FFQQIVNKQ 542
            F  ++   
Sbjct: 180 LFLDVLQNV 188


>UniRef50_B1I607 Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit
           n=1 Tax=Candidatus Desulforudis audaxviator MP104C
           RepID=B1I607_DESAP
          Length = 187

 Score =  218 bits (555), Expect = 5e-55,   Method: Composition-based stats.
 Identities = 66/186 (35%), Positives = 97/186 (52%), Gaps = 4/186 (2%)

Query: 360 KVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHPI 419
           K  +N P+ + +  ++   V   +SL G +    D AH  L + I  GK+LP  + +  I
Sbjct: 3   KKQINTPLTDEV--IADLHVGDHVSLNGKLYTVGDAAHKSLVQYIGQGKQLPFSLANQVI 60

Query: 420 YYAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHGG 479
           YYA     P G   GS+GPTTA RMD Y   L +  G   ++AKG RS +VT A  +H  
Sbjct: 61  YYAVATPPPPGRIVGSVGPTTATRMDCYTPTLLAQ-GLKGVVAKGYRSAEVTQAMREHRA 119

Query: 480 FYLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQIV 539
            Y G++ G AA+L+ + IK +   A+P LG EA+++  V DFP  ++ D  G D   +  
Sbjct: 120 VYFGAVCGVAALLS-RYIKSVRLAAFPGLGAEAVYEYTVADFPVVVINDIHGGDLHLEGR 178

Query: 540 NKQCAN 545
                N
Sbjct: 179 RVYALN 184


>UniRef50_B2TIM0 Fumarate hydratase, class I n=18 Tax=Bacteria RepID=B2TIM0_CLOBB
          Length = 185

 Score =  217 bits (554), Expect = 7e-55,   Method: Composition-based stats.
 Identities = 66/188 (35%), Positives = 104/188 (55%), Gaps = 4/188 (2%)

Query: 359 VKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHP 418
           +++ L+ P+     ++ +      + L+G I   RD AH +L EL+D  ++LP  I +  
Sbjct: 1   MEMKLHTPLTS--EKILKLKAGDTVLLSGIIYSARDAAHKRLIELLDKDEKLPLSIDNEI 58

Query: 419 IYYAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHG 478
           IYY GP+    G   GS GPTT+ RMDSY   L    G   M+ KG R+++V  +  K+ 
Sbjct: 59  IYYVGPSPAKPGSVIGSAGPTTSYRMDSYAPRLLDL-GLKGMIGKGARNEKVIKSIRKNK 117

Query: 479 GFYLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQI 538
             Y G+IGG AA++A+  +K  E +AY +LG EAI K+EV+D P  +++D  GN+ ++  
Sbjct: 118 AIYFGAIGGAAALIAKSIVKS-EIIAYEDLGAEAIRKMEVKDMPLVVIIDSAGNNLYEIG 176

Query: 539 VNKQCANC 546
                   
Sbjct: 177 QKDYLDTL 184


>UniRef50_C8QYN2 Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit
           n=1 Tax=Desulfurivibrio alkaliphilus AHT2
           RepID=C8QYN2_9DELT
          Length = 202

 Score =  217 bits (552), Expect = 1e-54,   Method: Composition-based stats.
 Identities = 63/179 (35%), Positives = 101/179 (56%), Gaps = 4/179 (2%)

Query: 362 DLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHPIYY 421
            +  P    +  +++      +SL+G +  GRD  H +L  L+D G+ LP  ++   +YY
Sbjct: 16  RVEVPFNPAV--VAELKAGELVSLSGVLYTGRDQTHRRLCALLDEGRPLPVDLRGQLLYY 73

Query: 422 AGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHGGFY 481
            GP     G   G+ GPTT+ RMD+Y   L    G    + KG RS++V  A   HG  Y
Sbjct: 74  VGPTPALPGRVIGAAGPTTSYRMDAYTPRLLEL-GLTATMGKGPRSEEVRQAMLAHGAIY 132

Query: 482 LGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQIVN 540
           L +IGG  A+L+ + I+  E VA+ + G EA+++ EVE+FPA ++ D  GNDF++++ +
Sbjct: 133 LATIGGAGALLS-RCIRKSELVAFADAGAEAMFRFEVENFPAVVINDLAGNDFYRRVSD 190


>UniRef50_B5YEU6 Fumarate hydratase, beta subunit n=2 Tax=Dictyoglomus
           RepID=B5YEU6_DICT6
          Length = 174

 Score =  216 bits (551), Expect = 1e-54,   Method: Composition-based stats.
 Identities = 64/170 (37%), Positives = 100/170 (58%), Gaps = 2/170 (1%)

Query: 367 MKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHPIYYAGPAK 426
           + E + +L +  V   + L G +   RD A  ++ ++++ G + P  +KD  IY+ GP+ 
Sbjct: 6   LPEDIGKLEEISVGEWILLNGALYSARDQACKRIVDMLEKGLKPPINLKDIIIYHMGPSP 65

Query: 427 TPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHGGFYLGSIG 486
            P G   GS GPTT+ RMD +V  L    G    + KG R ++V +A  K+ GFYL ++G
Sbjct: 66  APPGRVVGSAGPTTSKRMDPFVAKLMK-NGVKGFIGKGLRGREVIEAIRKYKGFYLVTVG 124

Query: 487 GPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQ 536
           G  A L  + IK ++ VA+PELG EA++ +EV DFP  + +D KGN F++
Sbjct: 125 GAGAYLGDR-IKSMKVVAFPELGPEAVYYLEVLDFPVLMAIDSKGNSFWE 173


>UniRef50_C9RML3 Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit
           n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85
           RepID=C9RML3_FIBSS
          Length = 281

 Score =  216 bits (550), Expect = 2e-54,   Method: Composition-based stats.
 Identities = 53/297 (17%), Positives = 94/297 (31%), Gaps = 32/297 (10%)

Query: 46  ALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAKGVLPTC 105
            +     +    A    R   QK+        E   N  +V  Q L N+ +A K   P C
Sbjct: 3   DIEQKVCECLIQAGSTFR-EDQKEAYRRAIAKEPGTNSCWVMQQVLDNALVAEKNRGPLC 61

Query: 106 QDTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEVN------ 159
            DTG   I  + G      G     +  G+     +   R       D ++         
Sbjct: 62  DDTGIPHIFIEVGPNRQVTGDVLAQIHAGIEAGLRKLPGRPMAILGDDYHRIDQSGGLNP 121

Query: 160 -TGTNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRT 218
            +G   P+ I +  V+ D  +   +  GGG      +   T+ +     ++  + E +  
Sbjct: 122 DSGALAPSPILIKPVEEDVLRLTILMLGGGP----AIRGITQRVFHKHSVQVVIDEIVAR 177

Query: 219 LGTA----ACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQ 274
              A     C P  +A  IG +  E     ++  +   YD                + E+
Sbjct: 178 AIPAVSQLGCSPCTLAVGIGRSQFEATSMMMEAMAKGNYD-------------FQSEFEK 224

Query: 275 ELLEEAQKLGLGA-QFGGKYFAHDIRVIRLPRHGASC-PVGMGVSCSAD-RNIKAKI 328
            + E   +  +GA   GGK           P+  +    V +   C  + R    ++
Sbjct: 225 TITERVNESNVGALGLGGKTSVLATFAKVGPQRASGVRIVALRPCCCFEPRRATVEL 281


>UniRef50_Q30V65 Hydro-lyases, Fe-S type, tartrate/fumarate subfamily, beta region
           n=3 Tax=Deltaproteobacteria RepID=Q30V65_DESDG
          Length = 181

 Score =  215 bits (547), Expect = 4e-54,   Method: Composition-based stats.
 Identities = 65/174 (37%), Positives = 94/174 (54%), Gaps = 4/174 (2%)

Query: 362 DLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHPIYY 421
            L  P++     + Q      + L+G I   RD AH ++ E +D+G   P   +   +YY
Sbjct: 5   HLTTPLRS--EDVLQLRAGDVVLLSGDIYTARDAAHKRIMEQLDSGGTPPFPPEGAVVYY 62

Query: 422 AGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHGGFY 481
            GPA  P G P GS GPTT+GRMDSY   + +  G    + KG R   V +A  +HG  Y
Sbjct: 63  VGPAPAPPGRPIGSAGPTTSGRMDSYTPRMLAL-GVRATIGKGKRCDAVRNAMCEHGAVY 121

Query: 482 LGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFF 535
           LG+ GG  A+L+ Q +   E VAY ELG EA+ +++V DFP  ++ D  G + +
Sbjct: 122 LGATGGAGALLS-QCVLAAEVVAYEELGPEAVRRLKVRDFPLLVINDACGGELY 174


>UniRef50_Q3YXI1 L(+)-tartrate dehydratase subunit beta n=108 Tax=Bacteria
           RepID=TTDB_SHISS
          Length = 201

 Score =  213 bits (542), Expect = 2e-53,   Method: Composition-based stats.
 Identities = 54/191 (28%), Positives = 89/191 (46%), Gaps = 10/191 (5%)

Query: 359 VKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHP 418
           +K  L  P+K     L    V   + LTGT++  RD+ H +L EL    + +P  +    
Sbjct: 1   MKKILTTPIK--AEDLQDIRVDDVIYLTGTLVTCRDVCHRRLIEL---KRPIPYDLNGKA 55

Query: 419 IYYAGPAKTPAG--YPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHK 476
           I++AGP     G  +   S+GPTT+ RM+S+        G  +++ KG       + C K
Sbjct: 56  IFHAGPIVRKNGDKWEMVSVGPTTSMRMESFEREFIEQTGVKLVVGKGGMGPLTEEGCQK 115

Query: 477 HGGFYLGSIGGPAAVLAQQSIKHLECVAYPELGM-EAIWKIEVEDF-PAFILVDDKGNDF 534
               ++    G  AVLA   ++ +E V + ELGM E++W   V++F P  + +D  GN+ 
Sbjct: 116 FKALHVIFPAGC-AVLAATQVEEIEEVHWTELGMPESLWVCRVKEFGPLIVSIDTHGNNL 174

Query: 535 FQQIVNKQCAN 545
             +        
Sbjct: 175 IAENKKLFAER 185


>UniRef50_D0TAD5 Fumarate hydratase n=1 Tax=Bacteroides sp. 2_1_33B
           RepID=D0TAD5_9BACE
          Length = 286

 Score =  212 bits (540), Expect = 3e-53,   Method: Composition-based stats.
 Identities = 56/297 (18%), Positives = 102/297 (34%), Gaps = 29/297 (9%)

Query: 43  EPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAKGVL 102
             E +  L      +A    R   +K+    +   E +E  K+V    L N+E A K   
Sbjct: 4   NYEKIVSLVCDTLVEAGSTFR-EDKKKAYKRVIASEDNERAKWVLETVLANAEAAEKNHS 62

Query: 103 PTCQDTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEVNTG- 161
           P C DTG   +V + GQ     G   + + +G+         R       D ++   +G 
Sbjct: 63  PLCDDTGIPHMVLEVGQDAAVTGRMLDAIREGIAEGLRRLPGRPMGIMGDDSHRIDQSGG 122

Query: 162 ---TNL---PAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTP---GKLKNFL 212
               +    PA I +     +  +   +  GGG A +   Y+      T     ++ N+ 
Sbjct: 123 LNPDSAGVEPAPILIRRCQDNVIRLHILMFGGGPAIRAKTYRVFHKHNTQVVLDEIVNWA 182

Query: 213 VEKMRTLGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQL 272
            E +  LG   C P  +A  +G +  E     ++                 G+     ++
Sbjct: 183 TEGVAQLG---CSPCTLAVGVGRSHFEATSMMLQA-------------QVDGRYDFQSEM 226

Query: 273 EQELLEEAQKLGLGA-QFGGKYFAHDIRVIRLPRHGASC-PVGMGVSCSADRNIKAK 327
           EQE+     +  +G     GK       +   P+  +    V +  +C  +  I + 
Sbjct: 227 EQEITRRVNEANIGPLGLHGKTSVIATFMKVGPQRASGVRIVCVRPTCCFEPRIASV 283


>UniRef50_D2RKV4 Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit
           n=15 Tax=Bacteria RepID=D2RKV4_ACIFE
          Length = 206

 Score =  212 bits (539), Expect = 3e-53,   Method: Composition-based stats.
 Identities = 58/198 (29%), Positives = 92/198 (46%), Gaps = 13/198 (6%)

Query: 358 AVKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDH 417
           A KV L+ P+K     +    +   + LTG I   RD+AH +L E    G++LP  ++  
Sbjct: 2   ANKVVLHTPIKS--EDIENLKIGDIVYLTGKITTCRDVAHRRLIE---EGRKLPVDLEGG 56

Query: 418 PIYYAGPAKTP-----AGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTD 472
            I++AGP   P       Y   S+GPTT+ RM+ +        G  +++ KG   Q   D
Sbjct: 57  AIFHAGPIVRPIEGKENAYEMVSIGPTTSMRMEKFEKDFIPQTGVKLIVGKGGMGQDTMD 116

Query: 473 ACHKHGGFYLGSIGGPAAVLAQQSIKHLECVAYPELGM-EAIWKIEVEDF-PAFILVDDK 530
           AC K+   +     G  AV++    K +    + +LGM E +W  EVE+  P  + VD K
Sbjct: 117 ACQKYKTIFCVFPAGC-AVVSAVHFKKIIDAQWKDLGMPETLWTSEVEELGPLIVAVDTK 175

Query: 531 GNDFFQQIVNKQCANCTK 548
           G + F++          +
Sbjct: 176 GGNLFEENKKTYKKRAEE 193


>UniRef50_C0CW47 Putative uncharacterized protein n=1 Tax=Clostridium asparagiforme
           DSM 15981 RepID=C0CW47_9CLOT
          Length = 197

 Score =  212 bits (539), Expect = 3e-53,   Method: Composition-based stats.
 Identities = 61/195 (31%), Positives = 97/195 (49%), Gaps = 9/195 (4%)

Query: 359 VKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHP 418
            K  L  P+KE    + +  +   + LTG I   RD+ H K++EL+DAG+ LP+      
Sbjct: 2   DKKVLTMPLKE--EDVRELKIGDVVYLTGHIYTARDMGHLKIRELLDAGQPLPKDFTGAA 59

Query: 419 IYYAGPA---KTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACH 475
           I++AGP         +    +GPTT+ RM+ + D +    G   ++ KG   +   DAC 
Sbjct: 60  IFHAGPVCLKNEDGSWRLNVIGPTTSIRMEPHAD-VVGKMGIKAVIGKGGMEKGTLDACE 118

Query: 476 KHGGFYLGSIGGPAAVLAQQSIKHLECVAYPELGM-EAIWKIEVEDF-PAFILVDDKGND 533
           K+G  YL +  G AA LA Q IK +  V + E+GM EA+W +E  +F P  + +D   N 
Sbjct: 119 KYGYVYLQAAPGCAAKLA-QGIKSVYDVTWFEMGMPEALWDLEAVEFGPLVVGMDTHQNS 177

Query: 534 FFQQIVNKQCANCTK 548
            ++ +         +
Sbjct: 178 IYKNLKEAALKKLDE 192


>UniRef50_C7IGU5 Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit
           n=1 Tax=Clostridium papyrosolvens DSM 2782
           RepID=C7IGU5_9CLOT
          Length = 204

 Score =  211 bits (537), Expect = 6e-53,   Method: Composition-based stats.
 Identities = 56/186 (30%), Positives = 94/186 (50%), Gaps = 9/186 (4%)

Query: 363 LNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHPIYYA 422
           L  P+K+    +++      + L+G +   RD+AH KLK+L+D+  +  + +    I++A
Sbjct: 6   LKTPLKD--EDIAKLEAGDTVYLSGKLYTARDMAHYKLKKLLDSNGKFDEDLNGQAIFHA 63

Query: 423 GPAK----TPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHG 478
           GP          Y   S+GPT++ RMD Y D++    G  I++ KG  S   T+A  KH 
Sbjct: 64  GPIISVNRESGEYKVISIGPTSSIRMDPYTDMV-GEMGVKILIGKGGMSDSTTEAMKKHT 122

Query: 479 GFYLGSIGGPAAVLAQQSIKHLECVAYPELGM-EAIWKIEVEDF-PAFILVDDKGNDFFQ 536
             YL +  G AAV  Q+  K        ++GM EA+W +E ++  P  + +D KG + F+
Sbjct: 123 MVYLLAAHGCAAVHTQRVTKVTHQYWMDKIGMPEAMWVMECDNLGPLIVGIDSKGRNLFE 182

Query: 537 QIVNKQ 542
           +     
Sbjct: 183 ETRKNS 188


>UniRef50_C1SNL1 Hydro-lyase family enzyme, Fe-S type, tartrate/fumarate subfamily
           n=1 Tax=Denitrovibrio acetiphilus DSM 12809
           RepID=C1SNL1_9BACT
          Length = 193

 Score =  210 bits (534), Expect = 1e-52,   Method: Composition-based stats.
 Identities = 50/188 (26%), Positives = 79/188 (42%), Gaps = 8/188 (4%)

Query: 361 VDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHPIY 420
           + L  P+ E   +     V   + LTGTI+  RD AH  + E  +    + +++KD  IY
Sbjct: 2   IKLTTPISE--EKARSLKVGDEVLLTGTIVTARDAAHKLMIE--ERPDFIREHLKDGVIY 57

Query: 421 YAGPAK---TPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKH 477
           + GP         Y   + GPTT+ R + Y   +        ++ KG    +  +   K 
Sbjct: 58  HCGPVVKQAENGEYSFVAAGPTTSSREEPYQAAVCEEYSVRAVIGKGGMGPKTAEGLKKV 117

Query: 478 GGFYLGSIGGPAAVLAQQSIKHLECVAYPELG-MEAIWKIEVEDFPAFILVDDKGNDFFQ 536
           G  YL ++GG  +++ +   K        E G  EA W  EVEDFP  + +D  G    +
Sbjct: 118 GAVYLHAVGGAGSLIGKMVKKVHTVYKLEEFGTPEAFWVCEVEDFPCVVTMDSHGGSLHK 177

Query: 537 QIVNKQCA 544
            I      
Sbjct: 178 DIAAASQK 185


>UniRef50_A5UKC4 Fumarate hydratase, alpha subunit n=4 Tax=Methanobrevibacter
           RepID=A5UKC4_METS3
          Length = 290

 Score =  209 bits (533), Expect = 2e-52,   Method: Composition-based stats.
 Identities = 55/302 (18%), Positives = 99/302 (32%), Gaps = 41/302 (13%)

Query: 46  ALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAKGVLPTC 105
            +      A   AS  L    +          E +EN  +   Q L N ++A+K   P C
Sbjct: 2   DIIEDVSNAIIKASTNLS-EDKFNALKKAISVEDNENALWALNQILENYKVASKTKFPLC 60

Query: 106 QDTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEVNTG--TN 163
            DTG   ++ + G++    G     +++G+         R       D+ +   +    N
Sbjct: 61  DDTGIPHVIIEIGEKREITGELIAQINEGIERGLNNLPARPMAVKGNDVERIEQSKGLYN 120

Query: 164 LPAQ-------IDLYAVDG--------DEYKFLCVAKGGGSANKTYLYQETKALLTPGKL 208
            P Q       ID ++ D         D      + +GGG      +  +T  +     +
Sbjct: 121 RPGQMKAASFLIDSFSEDSTYKRNISPDTLNIHFILEGGGPE----IRAKTYRVYHKRSI 176

Query: 209 KNFLVEKM----RTLGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHG 264
           +N +   +     +L    C P   A  IG T  E +              L  +   +G
Sbjct: 177 ENVIGTAIGWLSESLKMLGCTPSVPAVGIGRTHYEAS-------------SLLLKSIVYG 223

Query: 265 QAFRDVQLEQELLEEAQKLGLGA-QFGGKYFAHDIRVIRLPRHGASC-PVGMGVSCSADR 322
                  LE  + ++  +  +G   FGGK       V    +  +    V +  SC  + 
Sbjct: 224 NLDSQSDLENYVTQKLNETNIGPLGFGGKTTVLGSFVNVGNQRASGVRIVSVRPSCFVEP 283

Query: 323 NI 324
            +
Sbjct: 284 RV 285


>UniRef50_B2KBV4 Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit
           n=1 Tax=Elusimicrobium minutum Pei191 RepID=B2KBV4_ELUMP
          Length = 171

 Score =  208 bits (530), Expect = 4e-52,   Method: Composition-based stats.
 Identities = 64/177 (36%), Positives = 94/177 (53%), Gaps = 8/177 (4%)

Query: 361 VDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHPIY 420
           + L  P+   +  L +      + L+G I   RD AH +L E     K  P ++K   +Y
Sbjct: 2   IKLKTPLT--VKDLKKIKTGDSVLLSGVIYTARDKAHKQLLE----EKVFPSFLKGQIVY 55

Query: 421 YAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHGGF 480
           YAGPA  P G   GS+GPTT+GRMD +V  + S    +  + KG  S +  +A       
Sbjct: 56  YAGPAPAPKGKVVGSIGPTTSGRMDKFVKQILSKSDIIATIGKGMLSAEAKEAMVG-KAV 114

Query: 481 YLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQ 537
           Y  ++GG  A++A Q +K  ECV Y +LG EAI+K+EVE+ P  +  D  G+D F +
Sbjct: 115 YFAAMGGAGALIA-QCVKKCECVLYKDLGAEAIYKLEVENMPLIMAFDLYGSDIFWR 170


>UniRef50_O27932 Fumarate hydratase, class I related protein n=5
           Tax=Methanobacteriaceae RepID=O27932_METTH
          Length = 225

 Score =  207 bits (527), Expect = 1e-51,   Method: Composition-based stats.
 Identities = 49/190 (25%), Positives = 88/190 (46%), Gaps = 25/190 (13%)

Query: 359 VKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHP 418
           +++ L  P+     ++++  V   + + G I   RD AH ++ E     +  P  I+   
Sbjct: 4   MEIKLETPLS---EEVTELRVGDVVYINGRIFTARDRAHKRILE-----RGAPFDIEGSV 55

Query: 419 IYYAGPAKT-------------PAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGN 465
           I++AGP                        +GPTT+GRM+ +   +    G   ++ KG 
Sbjct: 56  IFHAGPIIRFNEEPNTTAESIRDPQAELVVVGPTTSGRMNPFQPEVLGL-GVRAVIGKGG 114

Query: 466 RSQQVTDACHKHGGFYLGSIGGPAAVLAQQSIKHLECVAYPELG-MEAIWKIEVEDF-PA 523
              +   A  ++G  YL ++GG AA+    ++K +  V + +LG  EAIW++EVE+F P 
Sbjct: 115 MDDRTGSALRRYGAVYLAAVGGCAALYG-SAVKGIRAVHWLDLGVPEAIWELEVEEFGPL 173

Query: 524 FILVDDKGND 533
            + +D  G  
Sbjct: 174 IVAMDSTGRS 183


>UniRef50_B5F039 Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta region
           n=16 Tax=Salmonella enterica RepID=B5F039_SALA4
          Length = 181

 Score =  207 bits (526), Expect = 1e-51,   Method: Composition-based stats.
 Identities = 65/184 (35%), Positives = 99/184 (53%), Gaps = 4/184 (2%)

Query: 361 VDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHPIY 420
           ++L  P+ +   +     V   L LTG     RD AH K++  +  G++ P   ++  IY
Sbjct: 2   MELTLPLTK--EKAKTLKVGDILFLTGFAYTCRDAAHKKIEVALSNGEKSPVDFQNQTIY 59

Query: 421 YAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHGGF 480
           YAGP     G P GS GPTTA RMD +V+++    G+   L KG+R+  V + C K+GG 
Sbjct: 60  YAGPCPARPGLPIGSNGPTTAARMDPFVEMMFQQ-GATAFLGKGDRADYVAELCKKYGGV 118

Query: 481 YLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQIVN 540
            L  IGG +A +  + +K +E VAY ELG E+I K+  + +   + +D +GN   +Q V 
Sbjct: 119 SLLGIGGASA-INTKHVKSVEIVAYEELGTESIKKLYFDRYRVIVGIDSEGNTLQKQEVP 177

Query: 541 KQCA 544
           K   
Sbjct: 178 KYAK 181


>UniRef50_C9KL19 L(+)-tartrate dehydratase subunit beta n=1 Tax=Mitsuokella
           multacida DSM 20544 RepID=C9KL19_9FIRM
          Length = 203

 Score =  204 bits (520), Expect = 5e-51,   Method: Composition-based stats.
 Identities = 55/194 (28%), Positives = 92/194 (47%), Gaps = 13/194 (6%)

Query: 360 KVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHPI 419
           K  L  P+    A L    V   + LTG +   RD+AH ++ E    G++LP  I+D  I
Sbjct: 3   KKVLTTPIS--AADLEDIHVGDVIYLTGELTTCRDVAHRRVIE---EGRKLPVDIRDGAI 57

Query: 420 YYAGPAKTPAG---YPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHK 476
            +AGP   P G   Y   ++GPTT+ RM+ + +      G  +++ KG         C  
Sbjct: 58  LHAGPIIRPRGEDDYEMVTVGPTTSMRMEKFEEAFIKETGVRLIIGKGGMGAGTMRGCRD 117

Query: 477 HGGFYLGSIGGPAAVLAQQSIKHLECVAYPELGM-EAIWKIEVEDF-PAFILVDDKGNDF 534
           +   +     G  AV+A   ++ +    + +LGM E +W  +V++F P  + +D  G++ 
Sbjct: 118 NKALHCVFPAGC-AVVAATCVEKILSANWKDLGMPETLWTCKVKEFGPLIVSIDTHGHNL 176

Query: 535 FQQIVNKQCANCTK 548
           F++  NK   N  K
Sbjct: 177 FEE--NKVIFNERK 188


>UniRef50_C8WG73 Fe-S type hydro-lyase tartrate/fumarate beta region n=2
           Tax=Coriobacteriaceae RepID=C8WG73_EGGLE
          Length = 181

 Score =  204 bits (520), Expect = 6e-51,   Method: Composition-based stats.
 Identities = 70/182 (38%), Positives = 94/182 (51%), Gaps = 5/182 (2%)

Query: 358 AVKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLK-ELIDAGKELPQYIKD 416
           A ++ L  P     A L++        LTG +   RD  H +L  EL  AG  LP  +  
Sbjct: 4   ADRIRLALPF--DRAALARLEAGDSCLLTGPLYTLRDAGHVRLLAELEAAGGALPYGLDG 61

Query: 417 HPIYYAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHK 476
             I+YAGP    AG P G++GPTTA RMD +        G    + KG RS +V DAC  
Sbjct: 62  QAIFYAGPTPEAAGRPFGAVGPTTASRMD-FAAPALHRAGVAATVGKGRRSSEVRDACRA 120

Query: 477 HGGFYLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQ 536
            G  Y  + GG AA LA + +   E VAY +LG EA+ +I+V DFP F+ VD +G D + 
Sbjct: 121 TGSVYFVACGGAAAYLA-KCVASSETVAYDDLGTEALRRIDVVDFPVFVGVDVRGRDVYD 179

Query: 537 QI 538
            +
Sbjct: 180 LV 181


>UniRef50_Q0RXW9 L(+)-tartrate dehydratase beta subunit n=2 Tax=Bacteria
           RepID=Q0RXW9_RHOSR
          Length = 201

 Score =  203 bits (516), Expect = 2e-50,   Method: Composition-based stats.
 Identities = 48/197 (24%), Positives = 83/197 (42%), Gaps = 8/197 (4%)

Query: 354 GEGEAVKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQY 413
              E   + L  P+ E+        V   + L GT+   RD +  +L +  +  +     
Sbjct: 2   ATEEQRTLRLRAPLTEV--DARDLRVGDEVWLDGTVWGIRDASLIRLFDQGERPEGT--D 57

Query: 414 IKDHPIYYAGPAKTPAG--YPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVT 471
            +     +  P+    G  Y   S+G TT+ RMD +     +  G+  ++ KG  S +  
Sbjct: 58  FEGALFIHTAPSVRKEGDRYLPVSVGTTTSMRMDRFTRGCLADIGARAIIGKGGLSDESL 117

Query: 472 DACHKHGGFYLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDF-PAFILVDDK 530
               + GG YL   GG A+      I+ +E V + +L  E +WK  V+DF P F+ +D  
Sbjct: 118 SHFQEFGGVYLAITGGAASW-ETLQIEEIEEVLWEDLMPECLWKFRVKDFGPLFVTMDSV 176

Query: 531 GNDFFQQIVNKQCANCT 547
           GN  ++Q+  +      
Sbjct: 177 GNSAYEQVRARAQQRLA 193


>UniRef50_B0VIF2 Tartrate dehydratase beta subunit (TtdB)/fumarate hydratase class
           I, beta chain (C-terminal) n=1 Tax=Candidatus
           Cloacamonas acidaminovorans RepID=B0VIF2_9BACT
          Length = 167

 Score =  202 bits (515), Expect = 2e-50,   Method: Composition-based stats.
 Identities = 54/168 (32%), Positives = 89/168 (52%), Gaps = 4/168 (2%)

Query: 360 KVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHPI 419
                 P+    A ++   +S ++ LTG +   RD+AH ++ +++  G++LP  + +  +
Sbjct: 3   TYRFTLPL--CPADIAPLHISDKVLLTGCLFTARDVAHKRMVDILKRGEKLPLNLAETTL 60

Query: 420 YYAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHGG 479
           +Y GP+    G   G++GPTT+ RMD Y  LL    G  +M+ KG RS +V  A    G 
Sbjct: 61  FYCGPSPARPGNICGAIGPTTSSRMDIYTPLLI-QNGLRVMIGKGERSIEVQKAIMDFGA 119

Query: 480 FYLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILV 527
            Y    GG +A L+Q  +   E   + ELG EAI K+ V+D P ++ +
Sbjct: 120 IYFVMPGGISAYLSQHIV-SCETFLWQELGPEAIHKLWVQDIPVYVAI 166


>UniRef50_A9BJS9 Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit
           n=9 Tax=Thermotogaceae RepID=A9BJS9_PETMO
          Length = 165

 Score =  201 bits (511), Expect = 7e-50,   Method: Composition-based stats.
 Identities = 57/166 (34%), Positives = 92/166 (55%), Gaps = 2/166 (1%)

Query: 370 ILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHPIYYAGPAKTPA 429
            + ++ +  +   L  TG +IV RD AH +L EL+    +LP  + +  ++YAGPA  P 
Sbjct: 2   KVNEIEKLKIGELLQYTGELIVMRDAAHQRLLELLSKNSQLPVDLNEKIVFYAGPANPPK 61

Query: 430 GYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHGGFYLGSIGGPA 489
               G++GPTT+ RMD Y++++    G +  + KG R+      C K+   Y  +  G A
Sbjct: 62  NSKIGAIGPTTSERMDKYLEMIFKL-GVLATVGKGKRNDLAVKLCIKYKRVYFITPSGAA 120

Query: 490 AVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFF 535
           A L+ + +K +  +A+ ELG EAI+ I V+DFP  + +D  GN  F
Sbjct: 121 AYLS-KCVKDIRVLAFAELGPEAIYNINVKDFPLMVAIDTSGNQIF 165


>UniRef50_C3PJK6 L-tartrate dehydratase n=19 Tax=Bacteria RepID=C3PJK6_CORA7
          Length = 213

 Score =  200 bits (509), Expect = 1e-49,   Method: Composition-based stats.
 Identities = 53/201 (26%), Positives = 86/201 (42%), Gaps = 17/201 (8%)

Query: 356 GEAVKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIK 415
                  L  P+ +    L        + L G I+  RD+ H ++ EL   G+ELP  +K
Sbjct: 3   ENTTAKTLTTPISQ--EDLQDIKAGDVIFLDGYIVTCRDVGHRRVVEL---GRELPLDLK 57

Query: 416 DHPIYYAGPAKTP---------AGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNR 466
              I +AGP               Y   S+GPTT+ RM+ +        G  +++ KG+ 
Sbjct: 58  GGAILHAGPIMQKVEGTDRNGDEKYEVVSVGPTTSMRMEMFEYDFIEQTGVRLIVGKGSM 117

Query: 467 SQQVTDACHKHGGFYLGSIGGPAAVLAQQSIKHLECVAYPELGM-EAIWKIEVEDF-PAF 524
                  C + G  +     G  AV+A   ++ +E   + ELGM EA+W + V+ F P  
Sbjct: 118 GPNTEAGCKEFGALHCVFPAG-NAVIAATEVEEVEESYWRELGMPEALWVMRVKQFGPLI 176

Query: 525 ILVDDKGNDFFQQIVNKQCAN 545
           + +D  GN+ + Q   +  A 
Sbjct: 177 VSIDANGNNLYTQKKEEYNAR 197


>UniRef50_A4YFS6 Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit
           n=1 Tax=Metallosphaera sedula DSM 5348
           RepID=A4YFS6_METS5
          Length = 191

 Score =  197 bits (500), Expect = 1e-48,   Method: Composition-based stats.
 Identities = 52/189 (27%), Positives = 92/189 (48%), Gaps = 9/189 (4%)

Query: 362 DLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHPIYY 421
            L  P+KE +  +    +   + L+G I + RD    ++    + G   P  +KD  +++
Sbjct: 3   KLETPLKEDV--VQSLRLGEEVYLSGKIYIMRDATLRRI---FEQGVAPPVNLKDQVVFF 57

Query: 422 AGPAKTPA--GYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHGG 479
             P+ T    GY   S+G TT+ RM+ Y+  L +  G   ++ KG  S+++     +   
Sbjct: 58  GAPSFTKDSNGYTILSVGVTTSQRMEKYIPRLLNELGVKGIVGKGELSERMNPEFSRAKS 117

Query: 480 FYLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDF-PAFILVDDKGNDFFQQI 538
            YL  +GG AA LA  SI+ +  V + +L  EA++++EV    PAF+ +D +G +   + 
Sbjct: 118 VYLLFVGGAAA-LATSSIQRVNKVWWEDLRGEALFEVEVNSLGPAFVAIDAQGGNLLMEN 176

Query: 539 VNKQCANCT 547
             K   N  
Sbjct: 177 REKVLRNLN 185


>UniRef50_A9HYF7 L-tartrate dehydratase, subunit B n=3 Tax=Proteobacteria
           RepID=A9HYF7_BORPD
          Length = 203

 Score =  196 bits (498), Expect = 2e-48,   Method: Composition-based stats.
 Identities = 53/193 (27%), Positives = 84/193 (43%), Gaps = 15/193 (7%)

Query: 362 DLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHPIYY 421
           +L+ P+ E   Q     V   ++L  T+   RD ++     L D G+     +  H + +
Sbjct: 5   NLDMPITET--QARALRVGDTVTLQHTLFGIRDASY---IALFDQGRATRFDMNGHAVIH 59

Query: 422 AGPAKT--------PAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDA 473
             P           PAGY S  +G TT+ RM+ +   L    G  +++ KG   Q    A
Sbjct: 60  TAPNVRKVAVSARNPAGYESVCIGTTTSARMERFTGQLMRQCGVRLIVGKGGMQQGSRQA 119

Query: 474 CHKHGGFYLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDF-PAFILVDDKGN 532
             + GG YL  +GG AA L    I+ +E V   +L  E++WK  + DF P  + +D  G 
Sbjct: 120 FMEQGGAYLAIVGGTAA-LETTWIESIEDVDLDDLNPESLWKFRIRDFGPLLVAMDSHGG 178

Query: 533 DFFQQIVNKQCAN 545
             + Q+     A 
Sbjct: 179 SLYDQVAEDVAAR 191


>UniRef50_O27044 Fumarate hydratase, class I related protein n=2 Tax=cellular
           organisms RepID=O27044_METTH
          Length = 280

 Score =  195 bits (497), Expect = 3e-48,   Method: Composition-based stats.
 Identities = 47/289 (16%), Positives = 85/289 (29%), Gaps = 26/289 (8%)

Query: 51  AQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAKGVLPTCQDTGT 110
            + A   AS    P   +       + E  E   ++    + N+ IA +   P C DTG 
Sbjct: 7   VRDAIIQASTTYSPDVLRA-YERALEVEEDERSAWILELLIENARIAERERRPLCDDTGI 65

Query: 111 AIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEVNTGTNL------ 164
             ++ + G+      G    L +GV     E   R       D  + +     L      
Sbjct: 66  PHLIVEVGEDASLPAGFFNHLKRGVEEGLRELPGRPMAVRG-DEVERIEQSRGLYSDPAK 124

Query: 165 --PAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRTLGTA 222
             PA   + +  G+  +   +  GGG   +    +           +  +      +   
Sbjct: 125 LPPAPFTVDSAPGEGVRIHVLMLGGGPEIRARTRRIFHRHSYRKVFEEVITWMKTEVPML 184

Query: 223 ACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLEEAQK 282
            C P   A  IG T  E     ++  +              G       +E+ + E    
Sbjct: 185 GCTPCIPAIGIGRTHFEATGLMLRAMA-------------TGNLDEQSWIEEHITESLNS 231

Query: 283 -LGLGAQFGGKYFAHDIRVIRLPRHGASC-PVGMGVSCSAD-RNIKAKI 328
                   GG   A    +   P+  +    V M ++C  + R     +
Sbjct: 232 TGTGPLGLGGSTTALGAMIKVGPQRASGVRIVSMRLACCVEPRRATIDL 280


>UniRef50_A7I689 Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit
           n=6 Tax=Euryarchaeota RepID=A7I689_METB6
          Length = 187

 Score =  194 bits (494), Expect = 7e-48,   Method: Composition-based stats.
 Identities = 53/185 (28%), Positives = 85/185 (45%), Gaps = 15/185 (8%)

Query: 360 KVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHPI 419
            + L  P+ +   ++       R+ L+GT+   RD AH ++       + +P   K   I
Sbjct: 5   TLQLTTPLGD---EVLSLMAGDRIELSGTVYTARDEAHLRM-----RKEGIPFDPKGAVI 56

Query: 420 YYAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHGG 479
           Y+ GP          + GPTT+ RM+S    L    G   ++ KG     V +     G 
Sbjct: 57  YHCGPVIKDN--KIIAAGPTTSARMNSLSGFLLD-AGVRGLIGKGGMDATVREQLRGRG- 112

Query: 480 FYLGSIGGPAAVLAQQSIKHLECVAYPELGM-EAIWKIEVEDFPAFILVDDKGNDFFQQI 538
            Y    GG AA+ A   I  L+ V +P+LGM EA+W+IE++  P  + +D +GND F ++
Sbjct: 113 VYFAFTGGCAALAASHMI--LKGVHFPDLGMAEAVWEIELDRLPLVVGIDAQGNDLFGKV 170

Query: 539 VNKQC 543
                
Sbjct: 171 REHAQ 175


>UniRef50_A1HQH2 Fe-S type hydro-lyases tartrate/fumarate alpha region n=1
           Tax=Thermosinus carboxydivorans Nor1 RepID=A1HQH2_9FIRM
          Length = 216

 Score =  192 bits (488), Expect = 3e-47,   Method: Composition-based stats.
 Identities = 48/169 (28%), Positives = 73/169 (43%), Gaps = 3/169 (1%)

Query: 39  ILKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAA 98
           +  +E   +T    +   +A++ L P           + E S   K +  Q + N+ IA 
Sbjct: 1   MRTLEAAQITAAVAKLAVEANYNLSPD-IYDALVAGREKEESPLGKEILGQLVTNACIAR 59

Query: 99  KGVLPTCQDTGTAIIVGKKGQRVWTGGG-DEETLSKGVYNTYIEDNLRYSQNAALDMYKE 157
           +  +P CQDTG A++  + GQ V   GG   + ++ GV   Y E  LR S      ++  
Sbjct: 60  EEAMPICQDTGMAVVFVELGQDVHITGGSLADAVNAGVAKGYTEGYLRKSVVD-DPLFDR 118

Query: 158 VNTGTNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPG 206
            NT  N PA + +  V GD+ K     KG GS N + L     A    G
Sbjct: 119 KNTQDNTPAILHVELVPGDKLKITLAPKGFGSENMSALKMFKPAEGVVG 167


>UniRef50_A7HKF0 Fe-S type hydro-lyase tartrate/fumarate beta region n=1
           Tax=Fervidobacterium nodosum Rt17-B1 RepID=A7HKF0_FERNB
          Length = 160

 Score =  186 bits (472), Expect = 2e-45,   Method: Composition-based stats.
 Identities = 54/159 (33%), Positives = 87/159 (54%), Gaps = 5/159 (3%)

Query: 371 LAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHPIYYAGPAKTPAG 430
              L +  V      TG +IV RD A  +L E+ D GK LP  +K+  ++YAGP  +   
Sbjct: 6   TETLKKLNVGEMFEYTGKLIVMRDAAQKRLVEMEDNGKTLPVELKNALVFYAGPTFSKGN 65

Query: 431 YPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHGGFYLGSIGGPAA 490
                +GPTT+ RMD +++ L  H G +  + KG R+ +  +   K+   Y  +  G AA
Sbjct: 66  II---IGPTTSKRMDRFLEFLGRH-GVIGTIGKGERTPEGVETIKKYKMIYFVTPSGCAA 121

Query: 491 VLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDD 529
            L ++ IK  + VA+ +LG EA+++IEVE+FP  +++  
Sbjct: 122 YLGKK-IKSWKVVAFEDLGPEAVYEIEVENFPLLVVISA 159


>UniRef50_B4UMA9 Fe-S type hydro-lyase tartrate/fumarate beta region n=3
           Tax=Anaeromyxobacter RepID=B4UMA9_ANASK
          Length = 191

 Score =  185 bits (469), Expect = 5e-45,   Method: Composition-based stats.
 Identities = 49/186 (26%), Positives = 81/186 (43%), Gaps = 8/186 (4%)

Query: 359 VKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHP 418
           +   L  P   +   +        + L G I+ GR+ AH  L    D   ++ ++ +   
Sbjct: 1   MPKTLTLP--ALPEDVRGLAAGDEVLLRGRIVTGREAAHRYLATHDD--PQVRRWTEGAV 56

Query: 419 IYYAGPAKTP---AGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACH 475
           +Y+ GP        G+   + GP+ +GR +++   + +  G   +L KG    +  +A  
Sbjct: 57  LYHCGPVVARAPGGGWRFVAAGPSASGRQEAWEAEVIARYGLRGVLGKGGMGPRTLEALR 116

Query: 476 KHGGFYLGSIGGPAAVLAQQSIKHLECVAYPELG-MEAIWKIEVEDFPAFILVDDKGNDF 534
            HG  YL + GG A  LA+   + L+      LG  EAIW  EVEDFPA + +D  G   
Sbjct: 117 AHGAVYLHAAGGLAVSLARHVTRVLDVARLDALGVTEAIWLAEVEDFPAVVTMDAHGETL 176

Query: 535 FQQIVN 540
             +   
Sbjct: 177 HARGAE 182


>UniRef50_B8GKV9 Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit
           n=1 Tax=Methanosphaerula palustris E1-9c
           RepID=B8GKV9_METPE
          Length = 190

 Score =  182 bits (463), Expect = 3e-44,   Method: Composition-based stats.
 Identities = 54/176 (30%), Positives = 82/176 (46%), Gaps = 15/176 (8%)

Query: 361 VDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHPIY 420
           VDL  P+ +   +        R++L+G +   RD AH ++ +     + +P       IY
Sbjct: 2   VDLRTPLGD---EFLSLVAGDRVTLSGMVYTARDEAHLRMMD-----EGIPFDPVGAAIY 53

Query: 421 YAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHGGF 480
           + GP  +       + GPTT+ RM+     L    G  +++ KG    QV +     G  
Sbjct: 54  HCGPVISHD--RVIAAGPTTSARMNDLSGFLLDK-GVRVLIGKGGMGSQVVEQLRGRG-V 109

Query: 481 YLGSIGGPAAVLAQQSIKHLECVAYPELGM-EAIWKIEVEDFPAFILVDDKGNDFF 535
           YL   GG AA+ A     HL  V YP+LGM EA+W IE++  P  + +D  G D F
Sbjct: 110 YLAFTGGCAALAATHM--HLTGVFYPDLGMAEAVWAIELDHLPLVVGIDAAGGDLF 163


>UniRef50_UPI000190D92B fumarate hydratase class I, anaerobic n=10 Tax=Salmonella enterica
           subsp. enterica serovar Typhi RepID=UPI000190D92B
          Length = 136

 Score =  175 bits (445), Expect = 3e-42,   Method: Composition-based stats.
 Identities = 119/136 (87%), Positives = 129/136 (94%)

Query: 1   MSNKPFIYQAPFPMGKDNTEYYLLTSDYVSVADFDGETILKVEPEALTLLAQQAFHDASF 60
           MS K FIYQAPFPMG+D TEYYLLTSDYVSV++F+GE+IL VEP+ALTLLAQQAFHDASF
Sbjct: 1   MSKKEFIYQAPFPMGEDKTEYYLLTSDYVSVSEFNGESILNVEPQALTLLAQQAFHDASF 60

Query: 61  MLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAKGVLPTCQDTGTAIIVGKKGQR 120
           MLRP HQ+QVAAILHDPEASENDKYVALQFLRNSEIAAKG+LPTCQDTGTAII+GKKGQR
Sbjct: 61  MLRPEHQQQVAAILHDPEASENDKYVALQFLRNSEIAAKGILPTCQDTGTAIIMGKKGQR 120

Query: 121 VWTGGGDEETLSKGVY 136
           VWTGGGDE  LSKGV+
Sbjct: 121 VWTGGGDEAALSKGVF 136


>UniRef50_B0NH77 Putative uncharacterized protein n=1 Tax=Clostridium scindens ATCC
           35704 RepID=B0NH77_EUBSP
          Length = 166

 Score =  167 bits (424), Expect = 7e-40,   Method: Composition-based stats.
 Identities = 52/186 (27%), Positives = 81/186 (43%), Gaps = 39/186 (20%)

Query: 359 VKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHP 418
           +   +  P+ + ++          + +TGTI   R                         
Sbjct: 19  MDKHITAPITKKVS--RTLRAGDYVYITGTIYTAR------------------------- 51

Query: 419 IYYAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHG 478
                      G   GS G TTA   D Y   L    G   M+ KG RS +V +A  ++G
Sbjct: 52  ----------EGRSIGSAGSTTASCRDRYALKLLDL-GLTAMIGKGKRSPEVLEAVKRNG 100

Query: 479 GFYLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQI 538
             YL ++GG  A+L+ + IK  E VAY +LG EAI K++VEDFPA ++ D +GN+ ++  
Sbjct: 101 SVYLAAVGGAGALLS-KCIKESEVVAYNDLGAEAIRKLKVEDFPAIVVADCEGNNLYETA 159

Query: 539 VNKQCA 544
           + +   
Sbjct: 160 IKEYQK 165


>UniRef50_Q28K74 Fe-S type hydro-lyases tartrate/fumarate beta protein n=14
           Tax=Proteobacteria RepID=Q28K74_JANSC
          Length = 226

 Score =  167 bits (422), Expect = 1e-39,   Method: Composition-based stats.
 Identities = 35/201 (17%), Positives = 84/201 (41%), Gaps = 12/201 (5%)

Query: 356 GEAVKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIK 415
            +  ++ L+         ++   +   + L+G +   R+  + +  E   A   +    +
Sbjct: 6   NKPREITLST--TPSAEAIADLRLGDVVYLSGLMYTAREGVYMRALE-DRANIPMELPAQ 62

Query: 416 DHPIYYAGPA---KTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNR-SQQVT 471
               ++  PA        +  G++  T + R   ++    +  G+ +++ KG   S+   
Sbjct: 63  SAANFHCSPAARINADGSFDMGAVTATASFRFAKWLPEWMAKTGAKLIVGKGGMTSKDYK 122

Query: 472 DACHKHGGFYLGSIG-GPAAVLAQQSIKHLECVAY-PELG-MEAIWKIEVEDF-PAFILV 527
           +    +G  YL ++G G  A+L  + ++++E V +  ELG  +A+W ++     P  +  
Sbjct: 123 EYFVPNGAVYLSTVGYGTGALLG-RGVENVEAVHWNEELGIAQAMWVLKCNRMGPFIVAS 181

Query: 528 DDKGNDFFQQIVNKQCANCTK 548
           D  G+  F++   K   N  +
Sbjct: 182 DMNGDCLFERENAKIAENVAR 202


>UniRef50_UPI0001C41F68 fumarate hydratase FumA4 n=1 Tax=Methanobrevibacter ruminantium M1
           RepID=UPI0001C41F68
          Length = 166

 Score =  165 bits (419), Expect = 3e-39,   Method: Composition-based stats.
 Identities = 40/177 (22%), Positives = 77/177 (43%), Gaps = 15/177 (8%)

Query: 361 VDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGK--ELPQYIKDHP 418
             +  P+ +    ++   +  ++SL+G +  GRD    KL + I+ G+  + P   K   
Sbjct: 2   KRITTPISDD--DINDLKIGDKISLSGKMYCGRDAVLPKLSKSIENGQEDKYPFDFKGMA 59

Query: 419 IYYAGPAKTPAGYPSGSLGPTTAGRMDSYVDL-LQSHGGSMIMLAKGNRSQQVTDACHKH 477
           I +         +    + PTT+ + +    +   S  G    + KG+ S +      K+
Sbjct: 60  IMH-------TAFSVAGIAPTTSNKAEIESSMEALSSAGVKFHIGKGSLSDETKKTLDKY 112

Query: 478 GGFYLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDF 534
              ++  +  P A L   ++   +CVAY E GMEA +++EV+D P  + +   G   
Sbjct: 113 NSIFI--VTPPVAALLTNNVISKKCVAYEEEGMEAFFELEVKDIPGIVAI-AHGKSL 166


>UniRef50_B5Y8W5 Putative uncharacterized protein n=1 Tax=Coprothermobacter
           proteolyticus DSM 5265 RepID=B5Y8W5_COPPD
          Length = 258

 Score =  165 bits (419), Expect = 3e-39,   Method: Composition-based stats.
 Identities = 51/236 (21%), Positives = 84/236 (35%), Gaps = 20/236 (8%)

Query: 87  ALQFLRNSEIAAKGVLPTCQDTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRY 146
                 N +++ +  LP CQDTG   +V   G    T     E   K  +     D  R 
Sbjct: 35  LEVLEENLDLSNRLNLPVCQDTGVVTLVV--GHDSLTRDELLEI--KTAFENCFNDLARP 90

Query: 147 SQNAALDMYKEVNTGTNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPG 206
           S  +    + +   G +   Q+       D+     V  G G+    +L        +  
Sbjct: 91  SMLS-SPFFGQHPLGRH---QVCFLEEVRDKRGLGAVISGAGTETHCFLKV-YPGTASWE 145

Query: 207 KLKNFLVEKMRTLGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQA 266
            + + L        + ACPP H    +GGT+AE     VK +   +       GN     
Sbjct: 146 TVVDDLQGWSSKRASLACPPVHFGVAVGGTAAE----AVKQSKLSFLF-----GNNFPTC 196

Query: 267 FRDVQLEQELLEEAQKLGLGAQFGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADR 322
           +      +EL+   +   +     G+ +A D+ +  LP H ++ PV M   C   R
Sbjct: 197 YEHAY--EELVNALRASTVDPLKNGESWAGDVFLRILPTHMSAVPVSMSFMCWPYR 250


>UniRef50_A1WMD4 Fumarate hydratase class I beta subunit n=1 Tax=Verminephrobacter
           eiseniae EF01-2 RepID=A1WMD4_VEREI
          Length = 205

 Score =  157 bits (398), Expect = 9e-37,   Method: Composition-based stats.
 Identities = 38/191 (19%), Positives = 74/191 (38%), Gaps = 8/191 (4%)

Query: 363 LNRPMKEILAQLSQYPVSTRLSLTGTIIV-GRDIAHAKLKELIDAGKELPQYIKDHPIYY 421
           L  P+     ++    V   ++L G I V      H ++ + +  G+ LP  ++    ++
Sbjct: 5   LVLPLSRD--KVRALAVGDMVTLDGEITVSIGLQTHQRMVQAVGDGQALPVDLRAGAFFH 62

Query: 422 AGPAKTPAGYPSGSL--GPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHGG 479
                   G     L   P+T+ R ++++  L       +   KG        A    G 
Sbjct: 63  LSTCVRDTGDGPQPLYTNPSTSTRYNAWMPSLVRGLDLRLTGGKGGLDAASVQALRDTGC 122

Query: 480 FYLGSIGGPAAVLAQQSIKHLECVAYPELGME-AIWKIEVEDF-PAFILVDDKGNDFFQQ 537
            YL  +GG  A L  + ++ L    + E   +  +  + V  F PA + +D  GN  ++Q
Sbjct: 123 VYLSFLGG-GAPLLSRGLRGLVSSHWNEYISQFRLLTLRVAAFGPATVAIDAHGNSLYEQ 181

Query: 538 IVNKQCANCTK 548
           +  +  A   +
Sbjct: 182 LRGQAQARMPQ 192


>UniRef50_C9RML5 Fe-S type hydro-lyase tartrate/fumarate beta region n=3
           Tax=Bacteria RepID=C9RML5_FIBSS
          Length = 167

 Score =  157 bits (396), Expect = 2e-36,   Method: Composition-based stats.
 Identities = 42/180 (23%), Positives = 80/180 (44%), Gaps = 19/180 (10%)

Query: 361 VDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAG--KELPQYIKDHP 418
           ++L  P  E    +++  V   +S++G I  GRD    K+ +  + G   E+   ++   
Sbjct: 2   IELTTPFSE--EDIAKLKVGDVVSISGYIYTGRDAVLPKIVKHAEEGTLSEVGVDLQGQV 59

Query: 419 IYYAGPAKTPAGYPSGSLGPTTAGRMD---SYVDLLQSHGGSMIMLAKGNRSQQVTDACH 475
           I++   +          +GPT++ +++   S+     S  G  + L KG    +   A  
Sbjct: 60  IFHTAVSPA-------GVGPTSSNKLEIESSFEP--LSRHGIKMHLGKGAIKPETVKALA 110

Query: 476 KHGGFYLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFF 535
           ++   +  ++  P   L +   +  E V YPELGMEA+ +I+V  + A I    KG   +
Sbjct: 111 ENNAVF--AVIPPVTALLESQTEEREVVCYPELGMEALHRIKVNKYQAIIAA-AKGESIY 167


>UniRef50_A5ULQ6 Fumarate hydratase, FumA n=3 Tax=Methanobrevibacter smithii
           RepID=A5ULQ6_METS3
          Length = 163

 Score =  155 bits (392), Expect = 4e-36,   Method: Composition-based stats.
 Identities = 42/175 (24%), Positives = 78/175 (44%), Gaps = 14/175 (8%)

Query: 361 VDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHPIY 420
             +  P+ +   ++S+  +  ++ L+G +  GRD A  +L ELI  GK  P       I 
Sbjct: 2   KKIKTPISD--EEISELQIGDKILLSGVMYTGRDAALPQLVELIKKGKT-PINTNGIAIM 58

Query: 421 YAGPAKTPAGYPSGSLGPTTAGRMDSY-VDLLQSHGGSMIMLAKGNRSQQVTDACHKHGG 479
           +   +          + PTT+ + +        S  G  I + KG  + +   A +K+  
Sbjct: 59  HTAVSDA-------GIAPTTSNKEEIESTIPFLSENGVKIHIGKGMLNDETKKALNKNNS 111

Query: 480 FYLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDF 534
            ++  I  P A L   ++   ECVA+   G+EA++K++VE+ P  + +   G   
Sbjct: 112 IFV--ITPPVAALLTNNVLEKECVAFENEGIEALYKLKVENIPGIVAI-AHGKSI 163


>UniRef50_UPI0001C35B8A Fe-S type hydro-lyase tartrate/fumarate beta region n=1
           Tax=Clostridium hathewayi DSM 13479 RepID=UPI0001C35B8A
          Length = 168

 Score =  147 bits (371), Expect = 1e-33,   Method: Composition-based stats.
 Identities = 45/176 (25%), Positives = 75/176 (42%), Gaps = 12/176 (6%)

Query: 361 VDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHPIY 420
           + +N P ++   +         + ++G I  GRD     + EL   G+     + +H I 
Sbjct: 2   IKINVPFRDKECR---LKAGDLIEMSGKIYCGRDAVLPYVVELAKKGE-----LSEHGIE 53

Query: 421 YAGPAKTPAGYPSGSLGPTTAGRMDSYVDLL-QSHGGSMIMLAKGNRSQQVTDACHKHGG 479
             G            + PTT  + +    ++  S  G+M  L KG    +  +   K+G 
Sbjct: 54  LDGAVIFHTAVSCAGIAPTTTSKPEIEGSMIPLSEKGAMFHLGKGRLLPETIEGLKKNGA 113

Query: 480 FYLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFF 535
           ++L  I  P + L   S+     V +PE GMEA ++I V+DFPA + V   G   F
Sbjct: 114 YFL--ITPPVSALLTASMSECRAVLHPEFGMEAFYEITVKDFPAIVAV-ADGESVF 166


>UniRef50_B9Z0L3 Tartrate dehydratase alpha subunit/Fumarate hydratase class I
           N-terminal domain-like protein n=1 Tax=Lutiella
           nitroferrum 2002 RepID=B9Z0L3_9NEIS
          Length = 219

 Score =  145 bits (365), Expect = 6e-33,   Method: Composition-based stats.
 Identities = 37/163 (22%), Positives = 53/163 (32%), Gaps = 12/163 (7%)

Query: 35  DGETILKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNS 94
           D E  ++   + +                P   K   A L   E +   K +      N 
Sbjct: 2   DKEAAVQSLTDVMAKFTAYIGKRL-----PKDVKAKLADLRTMETNPLAKSIYDSMAGNQ 56

Query: 95  EIAAKGVLPTCQDTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDM 154
           E A +   P+CQDTG      + G      G  EE L +          LR++   A++ 
Sbjct: 57  EAADRLNRPSCQDTGVIQYFVEAGANFPLLGELEEILQEATAEATRIGPLRHN---AVET 113

Query: 155 YKEVNTGTNLP---AQIDLYAVDG-DEYKFLCVAKGGGSANKT 193
           + E NTGTN       +D   V   D         GGG     
Sbjct: 114 FDEKNTGTNTGTNIPWLDWRIVPELDSCTIDVYMAGGGCTLPG 156


>UniRef50_C8T983 Fumarate hydratase class I n=3 Tax=Enterobacteriaceae
           RepID=C8T983_KLEPR
          Length = 105

 Score =  135 bits (340), Expect = 4e-30,   Method: Composition-based stats.
 Identities = 81/105 (77%), Positives = 96/105 (91%)

Query: 1   MSNKPFIYQAPFPMGKDNTEYYLLTSDYVSVADFDGETILKVEPEALTLLAQQAFHDASF 60
           MS KPF+YQ PFP+  D+TEYYLL+ ++VSVA+FDG+ +LKVEP+ALTLLAQQAFHDA+F
Sbjct: 1   MSTKPFVYQDPFPLAHDDTEYYLLSKEHVSVAEFDGQQVLKVEPQALTLLAQQAFHDAAF 60

Query: 61  MLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAKGVLPTC 105
           MLR +HQ+QV +IL DPEAS+NDKYVALQFLRNSEIAAKGVLPTC
Sbjct: 61  MLRVSHQQQVGSILLDPEASDNDKYVALQFLRNSEIAAKGVLPTC 105


>UniRef50_B5Y8W4 Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta region
           n=1 Tax=Coprothermobacter proteolyticus DSM 5265
           RepID=B5Y8W4_COPPD
          Length = 154

 Score =  125 bits (313), Expect = 7e-27,   Method: Composition-based stats.
 Identities = 45/163 (27%), Positives = 71/163 (43%), Gaps = 12/163 (7%)

Query: 377 YPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHPIYYAGPA-KTPAGYPSGS 435
                  S  G I + RD     + E    G+ LP       ++ AGP        P GS
Sbjct: 2   LREKQWYSCRGVIGITRDRGLQTICE---EGQHLP-----GVVFLAGPTLMAAKEAPLGS 53

Query: 436 LGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHGGFYLGSIGGPAAVLAQQ 495
            GPT+  RM  +++ +    G  +++AKG  S  V +   + G  Y  ++GG  A    +
Sbjct: 54  CGPTSVSRMLPFLEAMNRL-GVQLVIAKG-VSDGVLETFRRIGLSYGIAVGGAGAFYGTK 111

Query: 496 SIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQI 538
            IK +    Y  LG E  +  EV+DFP ++ V    + +F+ I
Sbjct: 112 -IKQVLSRKYESLGAEGFFLAEVQDFPFYVCVGGDVDGYFEPI 153


>UniRef50_O27187 Fumarate hydratase, class I n=1 Tax=Methanothermobacter
           thermautotrophicus str. Delta H RepID=O27187_METTH
          Length = 134

 Score =  118 bits (295), Expect = 8e-25,   Method: Composition-based stats.
 Identities = 29/141 (20%), Positives = 57/141 (40%), Gaps = 11/141 (7%)

Query: 363 LNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHPIYYA 422
           +   +     ++++  V  R+ + GTI  GRD A  KL + + AG+E P  +    I + 
Sbjct: 2   IRIELPATGDEIAKLSVGDRVLMDGTIYTGRDAALPKLVKALKAGEE-PINVMGAAIMHT 60

Query: 423 GPAKTPAGYPSGSLGPTTAGRMDSYVD-LLQSHGGSMIMLAKGNRSQQVTDACHKHGGFY 481
             +          + PT++ + D        +  G ++ + KG    +   A  + G  +
Sbjct: 61  AVSPA-------GIAPTSSNKEDIEESIPYLASRGVLVHIGKGKLGDETVRALKEAGAVF 113

Query: 482 LGSIGGPAAVLAQQSIKHLEC 502
           +  +  P A L    +K   C
Sbjct: 114 I--VTPPTAALLTSRVKSSRC 132


>UniRef50_A8F6X8 Putative uncharacterized protein n=1 Tax=Thermotoga lettingae TMO
           RepID=A8F6X8_THELT
          Length = 161

 Score =  116 bits (290), Expect = 3e-24,   Method: Composition-based stats.
 Identities = 30/167 (17%), Positives = 65/167 (38%), Gaps = 21/167 (12%)

Query: 374 LSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHPIYYAGPAKTPAGYPS 433
           + +   S  +  TG + V    A  ++     A   +P ++    I +        G+ +
Sbjct: 13  IRKLKTSDIVKYTGKLTVLSRQALERIIFYERAEGLIPDFMNGELICFGS---IKEGFLN 69

Query: 434 GSLGPTTAGRMDSYVDLLQS--HGGSMIMLAKGNRSQQVTDACHKHGGFYLGSIGGPAAV 491
                  + R   + DL +     GS+ +++K N +        ++G     ++  P A 
Sbjct: 70  IL-----SAR--DFEDLFEKIFLFGSVGIISKANSANPFY--FKRYGRVMFTAMEKPVA- 119

Query: 492 LAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQI 538
                 K  + +AY +L   A+ ++EVED    + +D +G     ++
Sbjct: 120 ------KSFKILAYSDLKSNAVMEVEVEDLLMRVTIDSRGTTKHVEV 160


>UniRef50_UPI000190C03B fumarase A (fumarate hydratase class I), aerobic isozyme n=1
           Tax=Salmonella enterica subsp. enterica serovar Typhi
           str. 404ty RepID=UPI000190C03B
          Length = 56

 Score = 48.4 bits (114), Expect = 7e-04,   Method: Composition-based stats.
 Identities = 30/40 (75%), Positives = 33/40 (82%)

Query: 132 SKGVYNTYIEDNLRYSQNAALDMYKEVNTGTNLPAQIDLY 171
           S+  Y    +DNLRYSQNA LDMYKEVNTG+NLPAQIDLY
Sbjct: 16  SQWAYLNLYQDNLRYSQNAPLDMYKEVNTGSNLPAQIDLY 55


Searching..................................................done


Results from round 2


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value
Sequences used in model and found again:

UniRef50_P40720 Fumarate hydratase class I, aerobic n=586 Tax=ce...   652   0.0  
UniRef50_Q7RE85 Fumarate hydratase class I, aerobic-related n=2 ...   572   e-161
UniRef50_Q8I2N6 Fumarate hydratase, putative n=1 Tax=Plasmodium ...   555   e-156
UniRef50_Q4UCY6 Fumarate hydratase class I, putative n=3 Tax=Aco...   549   e-155
UniRef50_B3L2U4 Fumarate hydratase, putative n=3 Tax=Plasmodium ...   548   e-154
UniRef50_A0KKZ8 Fumarate hydratase, class I n=388 Tax=cellular o...   502   e-140
UniRef50_Q04718 Fumarate hydratase class I, aerobic n=112 Tax=Ba...   486   e-135
UniRef50_D2M1S7 Hydro-lyase, Fe-S type, tartrate/fumarate subfam...   475   e-132
UniRef50_A8AAA8 Fumarase n=10 Tax=Archaea RepID=A8AAA8_IGNH4          461   e-128
UniRef50_C8PSZ3 Fumarate hydratase class I, anaerobic n=1 Tax=Tr...   455   e-126
UniRef50_B1B7A5 Fumarase n=4 Tax=Bacteria RepID=B1B7A5_CLOBO          346   9e-94
UniRef50_B2TIL9 Fumarate hydratase n=6 Tax=Clostridia RepID=B2TI...   340   8e-92
UniRef50_B4SZG5 Fumarate hydratase n=21 Tax=Salmonella enterica ...   333   8e-90
UniRef50_B1I426 Hydro-lyase, Fe-S type, tartrate/fumarate subfam...   329   2e-88
UniRef50_Q312U0 Fumarase alpha subunit n=1 Tax=Desulfovibrio des...   328   4e-88
UniRef50_Q1LBZ5 Fumarase alpha subunit n=20 Tax=Bacteria RepID=Q...   324   4e-87
UniRef50_Q469V4 Fumarase alpha subunit n=6 Tax=Archaea RepID=Q46...   321   6e-86
UniRef50_B1GZT9 Fumarate hydratase alpha subunit n=1 Tax=uncultu...   320   6e-86
UniRef50_A6Q389 Fumarate/tartrate hydratase, alpha subunit n=9 T...   314   5e-84
UniRef50_A6T6H6 Tartrate dehydratase n=1 Tax=Klebsiella pneumoni...   313   8e-84
UniRef50_A2BJ70 L(+)-tartrate dehydratase class I, alpha subunit...   312   3e-83
UniRef50_Q0W345 Fumarate hydratase (Fumarase), alpha subunit n=1...   308   4e-82
UniRef50_Q2RG69 Fumarase alpha subunit n=13 Tax=Bacteria RepID=Q...   306   1e-81
UniRef50_Q0RXW8 Fumarate hydratase, class I n=2 Tax=Bacteria Rep...   305   3e-81
UniRef50_B2KBV3 Hydro-lyase, Fe-S type, tartrate/fumarate subfam...   303   1e-80
UniRef50_B1L7M6 Tartrate dehydratase alpha subunit/Fumarate hydr...   302   2e-80
UniRef50_Q58690 Putative fumarate hydratase subunit alpha n=18 T...   301   5e-80
UniRef50_A2SQV2 Fumarase alpha subunit n=2 Tax=Methanomicrobiale...   299   2e-79
UniRef50_A9HYF3 Fumarate hydratase alpha subunit n=3 Tax=Proteob...   298   3e-79
UniRef50_A4YFS7 Fumarase alpha subunit n=1 Tax=Metallosphaera se...   296   1e-78
UniRef50_A4WJ46 Fumarase alpha subunit n=2 Tax=Thermoproteaceae ...   296   2e-78
UniRef50_B8GKW0 Hydro-lyase, Fe-S type, tartrate/fumarate subfam...   292   3e-77
UniRef50_A0B6L8 Fumarase alpha subunit n=1 Tax=Methanosaeta ther...   290   9e-77
UniRef50_B0VIF1 Tartrate dehydratase alpha subunit (TtdA)/Fumara...   289   1e-76
UniRef50_B5YEU7 Fumarate hydratase n=1 Tax=Dictyoglomus thermoph...   288   4e-76
UniRef50_C9KL20 L(+)-tartrate dehydratase subunit alpha n=1 Tax=...   283   1e-74
UniRef50_A8S1R3 Putative uncharacterized protein n=1 Tax=Clostri...   282   2e-74
UniRef50_Q0TD45 L(+)-tartrate dehydratase subunit alpha n=126 Ta...   280   1e-73
UniRef50_A9BJT0 Hydro-lyase, Fe-S type, tartrate/fumarate subfam...   269   1e-70
UniRef50_A1WMD3 Fumarase alpha subunit n=1 Tax=Verminephrobacter...   268   3e-70
UniRef50_B0EPH7 Serine acetyltransferase, putative n=10 Tax=cell...   267   5e-70
UniRef50_C7IGU6 Hydro-lyase, Fe-S type, tartrate/fumarate subfam...   264   6e-69
UniRef50_A7HKF1 Hydro-lyase, Fe-S type, tartrate/fumarate subfam...   259   2e-67
UniRef50_C8WG72 Hydro-lyase, Fe-S type, tartrate/fumarate subfam...   259   2e-67
UniRef50_Q8U062 Possible fumarate hydratase (Fumarase) alpha sub...   255   3e-66
UniRef50_Q3IXH2 Fumarase alpha subunit n=14 Tax=Proteobacteria R...   249   2e-64
UniRef50_Q2RG70 Hydro-lyases, Fe-S type, tartrate/fumarate subfa...   248   5e-64
UniRef50_A6TTM2 Hydro-lyase, Fe-S type, tartrate/fumarate subfam...   246   1e-63
UniRef50_C3PJK7 Tartrate dehydratase n=18 Tax=Bacteria RepID=C3P...   244   1e-62
UniRef50_C1SNL0 Hydro-lyase, Fe-S type, tartrate/fumarate subfam...   242   2e-62
UniRef50_B8I5L5 Hydro-lyase, Fe-S type, tartrate/fumarate subfam...   237   6e-61
UniRef50_A4XHH2 Hydro-lyase, Fe-S type, tartrate/fumarate subfam...   234   5e-60
UniRef50_Q58034 Putative fumarate hydratase subunit beta n=13 Ta...   234   8e-60
UniRef50_D1SM64 Hydro-lyase, Fe-S type, tartrate/fumarate subfam...   234   8e-60
UniRef50_C4GCC8 Putative uncharacterized protein n=1 Tax=Shuttle...   230   8e-59
UniRef50_UPI0001C35B8B hydro-lyase, Fe-S type, tartrate/fumarate...   226   2e-57
UniRef50_Q469V5 Fumarase beta subunit n=10 Tax=Archaea RepID=Q46...   225   3e-57
UniRef50_A1RT45 Fumarase beta subunit n=8 Tax=Thermoprotei RepID...   224   6e-57
UniRef50_D1BP97 Hydro-lyase, Fe-S type, tartrate/fumarate subfam...   224   7e-57
UniRef50_C9RML3 Hydro-lyase, Fe-S type, tartrate/fumarate subfam...   222   2e-56
UniRef50_D0TAD5 Fumarate hydratase n=1 Tax=Bacteroides sp. 2_1_3...   222   3e-56
UniRef50_Q1LBZ6 Hydro-lyases, Fe-S type, tartrate/fumarate subfa...   221   5e-56
UniRef50_Q0W346 Fumarate hydratase (Fumarase), beta subunit n=1 ...   219   3e-55
UniRef50_B2TIM0 Fumarate hydratase, class I n=18 Tax=Bacteria Re...   218   6e-55
UniRef50_C8QYN2 Hydro-lyase, Fe-S type, tartrate/fumarate subfam...   217   9e-55
UniRef50_B1I607 Hydro-lyase, Fe-S type, tartrate/fumarate subfam...   217   1e-54
UniRef50_B1L7M7 Tartrate dehydratase beta subunit/Fumarate hydra...   217   1e-54
UniRef50_A5UKC4 Fumarate hydratase, alpha subunit n=4 Tax=Methan...   215   2e-54
UniRef50_B5YEU6 Fumarate hydratase, beta subunit n=2 Tax=Dictyog...   214   6e-54
UniRef50_Q3YXI1 L(+)-tartrate dehydratase subunit beta n=108 Tax...   213   1e-53
UniRef50_Q30V65 Hydro-lyases, Fe-S type, tartrate/fumarate subfa...   213   1e-53
UniRef50_D2RKV4 Hydro-lyase, Fe-S type, tartrate/fumarate subfam...   212   3e-53
UniRef50_C0CW47 Putative uncharacterized protein n=1 Tax=Clostri...   210   7e-53
UniRef50_C7IGU5 Hydro-lyase, Fe-S type, tartrate/fumarate subfam...   209   2e-52
UniRef50_C1SNL1 Hydro-lyase family enzyme, Fe-S type, tartrate/f...   209   2e-52
UniRef50_O27044 Fumarate hydratase, class I related protein n=2 ...   208   4e-52
UniRef50_Q0RXW9 L(+)-tartrate dehydratase beta subunit n=2 Tax=B...   207   1e-51
UniRef50_B5F039 Hydro-lyase, Fe-S type, tartrate/fumarate subfam...   206   2e-51
UniRef50_O27932 Fumarate hydratase, class I related protein n=5 ...   205   3e-51
UniRef50_B2KBV4 Hydro-lyase, Fe-S type, tartrate/fumarate subfam...   205   3e-51
UniRef50_C8WG73 Fe-S type hydro-lyase tartrate/fumarate beta reg...   203   1e-50
UniRef50_B0VIF2 Tartrate dehydratase beta subunit (TtdB)/fumarat...   203   1e-50
UniRef50_C9KL19 L(+)-tartrate dehydratase subunit beta n=1 Tax=M...   202   2e-50
UniRef50_A9BJS9 Hydro-lyase, Fe-S type, tartrate/fumarate subfam...   199   3e-49
UniRef50_C3PJK6 L-tartrate dehydratase n=19 Tax=Bacteria RepID=C...   199   3e-49
UniRef50_A9HYF7 L-tartrate dehydratase, subunit B n=3 Tax=Proteo...   194   6e-48
UniRef50_A4YFS6 Hydro-lyase, Fe-S type, tartrate/fumarate subfam...   194   1e-47
UniRef50_A1HQH2 Fe-S type hydro-lyases tartrate/fumarate alpha r...   193   1e-47
UniRef50_A7I689 Hydro-lyase, Fe-S type, tartrate/fumarate subfam...   193   2e-47
UniRef50_B4UMA9 Fe-S type hydro-lyase tartrate/fumarate beta reg...   187   1e-45
UniRef50_A7HKF0 Fe-S type hydro-lyase tartrate/fumarate beta reg...   184   6e-45
UniRef50_B8GKV9 Hydro-lyase, Fe-S type, tartrate/fumarate subfam...   180   1e-43
UniRef50_B0NH77 Putative uncharacterized protein n=1 Tax=Clostri...   172   5e-41
UniRef50_B5Y8W5 Putative uncharacterized protein n=1 Tax=Coproth...   166   2e-39
UniRef50_UPI000190D92B fumarate hydratase class I, anaerobic n=1...   166   2e-39
UniRef50_UPI0001C41F68 fumarate hydratase FumA4 n=1 Tax=Methanob...   163   1e-38
UniRef50_Q28K74 Fe-S type hydro-lyases tartrate/fumarate beta pr...   163   1e-38
UniRef50_A1WMD4 Fumarate hydratase class I beta subunit n=1 Tax=...   159   2e-37
UniRef50_C9RML5 Fe-S type hydro-lyase tartrate/fumarate beta reg...   155   4e-36
UniRef50_A5ULQ6 Fumarate hydratase, FumA n=3 Tax=Methanobrevibac...   155   5e-36
UniRef50_B9Z0L3 Tartrate dehydratase alpha subunit/Fumarate hydr...   148   7e-34
UniRef50_UPI0001C35B8A Fe-S type hydro-lyase tartrate/fumarate b...   144   7e-33
UniRef50_C8T983 Fumarate hydratase class I n=3 Tax=Enterobacteri...   125   4e-27
UniRef50_B5Y8W4 Hydro-lyase, Fe-S type, tartrate/fumarate subfam...   125   4e-27
UniRef50_O27187 Fumarate hydratase, class I n=1 Tax=Methanotherm...   118   4e-25
UniRef50_A8F6X8 Putative uncharacterized protein n=1 Tax=Thermot...   115   5e-24
UniRef50_UPI000190C03B fumarase A (fumarate hydratase class I), ...    48   0.001

Sequences not found previously or not previously below threshold:


CONVERGED!
>UniRef50_P40720 Fumarate hydratase class I, aerobic n=586 Tax=cellular organisms
           RepID=FUMA_SALTY
          Length = 580

 Score =  652 bits (1682), Expect = 0.0,   Method: Composition-based stats.
 Identities = 484/543 (89%), Positives = 511/543 (94%)

Query: 1   MSNKPFIYQAPFPMGKDNTEYYLLTSDYVSVADFDGETILKVEPEALTLLAQQAFHDASF 60
           MSNKPF YQ PFP+ KD+TEYYLLTS++VSVA+F+G+ ILKV PEALTLLA+QAFHDASF
Sbjct: 1   MSNKPFFYQDPFPLKKDDTEYYLLTSEHVSVAEFEGQEILKVAPEALTLLARQAFHDASF 60

Query: 61  MLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAKGVLPTCQDTGTAIIVGKKGQR 120
           MLRPAHQ+QVA IL DP+ASENDKYVALQFLRNS+IAAKGVLPTCQDTGTAIIVGKKGQR
Sbjct: 61  MLRPAHQQQVADILRDPQASENDKYVALQFLRNSDIAAKGVLPTCQDTGTAIIVGKKGQR 120

Query: 121 VWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEVNTGTNLPAQIDLYAVDGDEYKF 180
           VWTGGGDE  L++GVYNTYIEDNLRYSQNAALDMYKEVNTGTNLPAQIDLY+VDGDEYKF
Sbjct: 121 VWTGGGDEAALARGVYNTYIEDNLRYSQNAALDMYKEVNTGTNLPAQIDLYSVDGDEYKF 180

Query: 181 LCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRTLGTAACPPYHIAFVIGGTSAET 240
           LC+AKGGGSANKTYLYQETKALLTPGKLKN+LV+KMRTLGTAACPPYHIAFVIGGTSAE 
Sbjct: 181 LCIAKGGGSANKTYLYQETKALLTPGKLKNYLVDKMRTLGTAACPPYHIAFVIGGTSAEA 240

Query: 241 NLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLEEAQKLGLGAQFGGKYFAHDIRV 300
           NLKTVKLASA YYD LPTEGNEHGQAFRD++LE+ELL EAQ LGLGAQFGGKYFAHDIRV
Sbjct: 241 NLKTVKLASAKYYDALPTEGNEHGQAFRDIELEKELLLEAQNLGLGAQFGGKYFAHDIRV 300

Query: 301 IRLPRHGASCPVGMGVSCSADRNIKAKINREGIWIEKLEHNPGQYIPQELRQAGEGEAVK 360
           IRLPRHGASCPVGMGVSCSADRNIKAKINR+GIWIEKLE NPG+YIP+ LRQAGEGEAV+
Sbjct: 301 IRLPRHGASCPVGMGVSCSADRNIKAKINRDGIWIEKLERNPGKYIPEALRQAGEGEAVR 360

Query: 361 VDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHPIY 420
           VDLNRPM EIL QLSQYPVSTRLSL GTIIVGRDIAHAKLKE +D G+ LPQYIKDHPIY
Sbjct: 361 VDLNRPMSEILQQLSQYPVSTRLSLNGTIIVGRDIAHAKLKERMDRGEGLPQYIKDHPIY 420

Query: 421 YAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHGGF 480
           YAGPAKTP GY SGSLGPTTAGRMDSYVD LQS GGSMIMLAKGNRSQQVTDAC KHGGF
Sbjct: 421 YAGPAKTPEGYASGSLGPTTAGRMDSYVDQLQSQGGSMIMLAKGNRSQQVTDACKKHGGF 480

Query: 481 YLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQIVN 540
           YLGSIGGPAAVLAQ SIK LECV YPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQI +
Sbjct: 481 YLGSIGGPAAVLAQGSIKRLECVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQIQS 540

Query: 541 KQC 543
            QC
Sbjct: 541 SQC 543


>UniRef50_Q7RE85 Fumarate hydratase class I, aerobic-related n=2 Tax=Plasmodium
           (Vinckeia) RepID=Q7RE85_PLAYO
          Length = 671

 Score =  572 bits (1474), Expect = e-161,   Method: Composition-based stats.
 Identities = 265/572 (46%), Positives = 370/572 (64%), Gaps = 39/572 (6%)

Query: 8   YQAPFPMGKDNTEYYLLTSDYVSVADFDGETILKVEPEALTLLAQQAFHDASFMLRPAHQ 67
           Y+       DN    +  +          +  + V P  LT L + A  +  F L   H 
Sbjct: 101 YEDENEFFDDNGNLKIKNNYEKESKKNVIKEYIHVPPFVLTKLCEYALKEILFFLNKNHL 160

Query: 68  KQVAAILHDPEASENDKYVALQFLRNSEIAAKGVLPTCQDTGTAIIVGKKGQRVWTGGGD 127
           KQ+  IL D  +SENDK+VA+  ++N+ I++   LP CQDTGTAII+GKK + +      
Sbjct: 161 KQLQNILIDKNSSENDKFVAMTLIKNAIISSNQNLPGCQDTGTAIILGKKDEEILVTYE- 219

Query: 128 EETLSKGVYNTYIEDNLRYSQNAALDMYKEVNTGTNLPAQIDLY------------AVDG 175
            + ++ GVYN Y ++N RYSQ + ++M+ E+NT  NLP QI++Y                
Sbjct: 220 HKYITLGVYNAYKKNNFRYSQLSPINMFDEINTKNNLPCQIEIYSNIKKKENLNDKIKKD 279

Query: 176 DEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRTLGTAACPPYHIAFVIGG 235
            +Y+   +AKGGGSANKT+L+Q+TK++L   K  +FL++K++ +GT+ACPPYH+A VIGG
Sbjct: 280 PKYELTFIAKGGGSANKTFLFQQTKSILNKDKXYDFLLDKIKEIGTSACPPYHLAIVIGG 339

Query: 236 TSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLEEAQKLGLGAQFGGKYFA 295
            S E NLKTVKLAS  Y D+LP EG  +G+AFRD++ E+ +L+++Q L +GAQFGGKYF 
Sbjct: 340 LSPEMNLKTVKLASCRYLDDLPKEGGIYGKAFRDLESEKIILDKSQNLXIGAQFGGKYFV 399

Query: 296 HDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINREGIWIEKLEHNPGQYIPQ------- 348
           HD+RVIRLPRH ASCP+ + VSCSADR IK+ IN+ G++IE LEH+P +Y+P+       
Sbjct: 400 HDVRVIRLPRHSASCPIXIXVSCSADRQIKSVINKNGVFIEDLEHDPIKYLPEVTYDNLK 459

Query: 349 ------------------ELRQAGEGEAVKVDLNRPMKEILAQLSQYPVSTRLSLTGTII 390
                               ++  +   V +DLN+P++ IL  +S YPVST L LTG +I
Sbjct: 460 SGKFRKTEKSEKSENFESGEKKCEQNNGVAIDLNQPIENILKIISNYPVSTLLILTGKLI 519

Query: 391 VGRDIAHAKLKE-LIDAGKELPQYIKDHPIYYAGPAKTPAGYPSGSLGPTTAGRMDSYVD 449
           V RD AH K+ +  I+    +P Y K HPIYYAGPAKTP  Y SGS GPTTAGRMD+Y +
Sbjct: 520 VARDTAHKKIVDNFINKNIPIPDYFKKHPIYYAGPAKTPYNYASGSFGPTTAGRMDAYAE 579

Query: 450 LLQSHGGSMIMLAKGNRSQQVTDACHKHGGFYLGSIGGPAAVLAQQSIKHLECVAYPELG 509
           +L  +  S+I LAKGNRS  V +AC K+ GFYLGSIGGP A+LA+ +I++++ + + ELG
Sbjct: 580 ILMKNNASLISLAKGNRSIVVKNACKKYNGFYLGSIGGPGAILAKNNIRNVKVIDFHELG 639

Query: 510 MEAIWKIEVEDFPAFILVDDKGNDFFQQIVNK 541
           MEA+  IEV DFPAFI++D+KGNDF+ + +  
Sbjct: 640 MEAVHLIEVVDFPAFIIIDNKGNDFYNKWIPS 671


>UniRef50_Q8I2N6 Fumarate hydratase, putative n=1 Tax=Plasmodium falciparum 3D7
           RepID=Q8I2N6_PLAF7
          Length = 681

 Score =  555 bits (1431), Expect = e-156,   Method: Composition-based stats.
 Identities = 267/584 (45%), Positives = 373/584 (63%), Gaps = 59/584 (10%)

Query: 16  KDNTEYYLLTSDYVSVADFDGETILKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILH 75
             N + Y+   +   +     +  + + P  LT L + AF +  F L   H KQ+  IL 
Sbjct: 99  HGNIKEYIYNENKKLLYKNYEKEYIHIPPFVLTKLCEYAFKEILFFLNKKHLKQLQHILQ 158

Query: 76  DPEASENDKYVALQFLRNSEIAAKGVLPTCQDTGTAIIVGKKGQRVWTGGGDEETLSKGV 135
           D E+S+NDKYVA+  ++N+ I+++  LP CQDTGTAII+GKK + + T     + L+ GV
Sbjct: 159 DKESSKNDKYVAMTLIKNAIISSEQKLPGCQDTGTAIILGKKDEDILTTYE-HKYLTLGV 217

Query: 136 YNTYIEDNLRYSQNAALDMYKEV------------------------------------- 158
           YN Y  +N RYSQ + L+M+ EV                                     
Sbjct: 218 YNAYKYNNFRYSQLSPLNMFNEVNTKNNLPCQIEIYTNIKKEKLHEVQQNEYPNHMKDIQ 277

Query: 159 ---NTGTN---LPAQID-------------LYAVDGDEYKFLCVAKGGGSANKTYLYQET 199
              N   N      QID              +  DG +Y+ + +AKGGGSANKT+L+Q+T
Sbjct: 278 NNNNVKHNKDITTRQIDSKENQKSTKKQNVDFLYDGPKYELIFIAKGGGSANKTFLFQQT 337

Query: 200 KALLTPGKLKNFLVEKMRTLGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTE 259
           K++L    L NFL++K++ +GT+ACPPYH+A VIGG SAE NLK VKLAS  Y D L TE
Sbjct: 338 KSILNEENLYNFLLDKIKEIGTSACPPYHLAIVIGGLSAEMNLKMVKLASCRYLDNLKTE 397

Query: 260 GNEHGQAFRDVQLEQELLEEAQKLGLGAQFGGKYFAHDIRVIRLPRHGASCPVGMGVSCS 319
           G  +G+AFRD++ E+ +L++AQ LG+GAQFGGKYF HD+RVIRLPRH ASCP+G+GVSCS
Sbjct: 398 GGIYGKAFRDLESEKIILQKAQSLGIGAQFGGKYFVHDVRVIRLPRHSASCPIGIGVSCS 457

Query: 320 ADRNIKAKINREGIWIEKLEHNPGQYIPQ-ELRQAGEGEAVKVDLNRPMKEILAQLSQYP 378
           ADR IK  IN+ G++++ LEH P +Y+P+   +   +  AVK+DLN+ M++ L  LS+YP
Sbjct: 458 ADRQIKCLINKNGVFMQMLEHEPIKYLPEITFKDLNQENAVKIDLNQNMEQTLKTLSKYP 517

Query: 379 VSTRLSLTGTIIVGRDIAHAKLKE-LIDAGKELPQYIKDHPIYYAGPAKTPAGYPSGSLG 437
            ST + LTG ++V RD AH K+ +  I+    +P+Y K +PIYYAGPAKTP  Y SGS G
Sbjct: 518 TSTLVLLTGKLVVARDSAHKKIVDQFINDNVPIPEYFKKYPIYYAGPAKTPDNYASGSFG 577

Query: 438 PTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHGGFYLGSIGGPAAVLAQQSI 497
           PTTAGRMD+Y ++L  +  S+I LAKGNRS  V +AC K+ GFYLGSIGGP A+LA+ +I
Sbjct: 578 PTTAGRMDAYAEVLMKNNASLISLAKGNRSAVVRNACKKYNGFYLGSIGGPGAILAKNNI 637

Query: 498 KHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQIVNK 541
           K+++ + + ++GMEA+  I+V DFPAFI++D+KGNDF+ + +  
Sbjct: 638 KNVQVIDFKDMGMEAVHLIDVVDFPAFIVIDNKGNDFYNKWLPS 681


>UniRef50_Q4UCY6 Fumarate hydratase class I, putative n=3 Tax=Aconoidasida
           RepID=Q4UCY6_THEAN
          Length = 622

 Score =  549 bits (1416), Expect = e-155,   Method: Composition-based stats.
 Identities = 285/552 (51%), Positives = 381/552 (69%), Gaps = 24/552 (4%)

Query: 10  APFPMGKDNTEYYLLTSDYVSVADFDGETI--LKVEPEALTLLAQQAFHDASFMLRPAHQ 67
                 + +    LL  +  ++   DG  +  L V PE LT L   AF +    LR  H 
Sbjct: 73  DTVKFKRLDDLSKLLRLNESNLVKSDGTNLKFLNVPPEVLTQLTSLAFTEIMHFLRTEHL 132

Query: 68  KQVAAILHDPEASENDKYVALQFLRNSEIAAKGV----------LPTCQDTGTAIIVGKK 117
            Q+  +  DPE+S+ND++V++Q L+N+ I+A             LP CQDTGTAI++GK+
Sbjct: 133 AQLRKVFDDPESSDNDRFVSMQLLKNACISAGKYFFLLILLYRVLPGCQDTGTAIVIGKR 192

Query: 118 GQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEVNTGTNLPAQIDLYAVDGDE 177
           G  +     D  +++KG+YN YI  N RYSQ +AL+MY+EVNT  NLPAQ++LY+ DG +
Sbjct: 193 GNNI-FSENDTNSITKGIYNCYINKNFRYSQMSALNMYEEVNTRCNLPAQVELYSQDGID 251

Query: 178 YKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRTLGTAACPPYHIAFVIGGTS 237
           Y+FL +AKGGGSANKT+LYQ+TK++L    L  FL+E+++T+GT+ACPPYH+A VIGG S
Sbjct: 252 YEFLFIAKGGGSANKTFLYQQTKSILNEKMLIEFLMEQIKTIGTSACPPYHLAIVIGGLS 311

Query: 238 AETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLEEAQKLGLGAQFGGKYFAHD 297
           AE  LKTVKLAS  Y D LPTEGN  G AFRD+  EQ +L++ +++G+GAQFGGKYF HD
Sbjct: 312 AEMTLKTVKLASCKYLDNLPTEGNLFGNAFRDLDFEQTILQKTREIGIGAQFGGKYFCHD 371

Query: 298 IRVIRLPRHGASCPVGMGVSCSADRNIKAKINREG----------IWIEKLEHNPGQYIP 347
           +R+IRLPRHGASCP+G+GVSCSADR + AKIN  G          +++E+LEH+P Q++P
Sbjct: 372 VRIIRLPRHGASCPIGIGVSCSADRQVLAKINPTGGLLIIFQYFLVYLEELEHDPAQFLP 431

Query: 348 QELRQAGEGEAVKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAG 407
             +      + + +DL   M+++L Q+ ++PV TRL L G +IV RDIAHA + E  D  
Sbjct: 432 T-IGHVPNTKEINIDLTIGMEKVLEQVRKFPVKTRLLLNGPLIVARDIAHAMIVEQFDKT 490

Query: 408 KELPQYIKDHPIYYAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRS 467
            +LP YIKD PIYYAGPAK P GY SGS GPTTAGRMDSY   L  HG S+I LAKGNRS
Sbjct: 491 GQLPNYIKDFPIYYAGPAKRPDGYVSGSFGPTTAGRMDSYASKLMEHGASLITLAKGNRS 550

Query: 468 QQVTDACHKHGGFYLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILV 527
           +   +AC K GG YLGS+GGPAA++A+  I+ +E V +P+LGMEA+ KI V++FPAF++V
Sbjct: 551 RSFVNACKKFGGVYLGSVGGPAALIAEDCIESVEVVDFPQLGMEAVHKILVKNFPAFVVV 610

Query: 528 DDKGNDFFQQIV 539
           D KGNDF+ Q  
Sbjct: 611 DSKGNDFYSQWS 622


>UniRef50_B3L2U4 Fumarate hydratase, putative n=3 Tax=Plasmodium RepID=B3L2U4_PLAKH
          Length = 673

 Score =  548 bits (1411), Expect = e-154,   Method: Composition-based stats.
 Identities = 278/585 (47%), Positives = 372/585 (63%), Gaps = 53/585 (9%)

Query: 8   YQAPFPMGKDNTEYYLLTSDYVSVADFDGETILKVEPEALTLLAQQAFHDASFMLRPAHQ 67
           ++        N E   L            +  + + P  LT L + AF +  F L   H 
Sbjct: 89  FENEDNFFHPNGELKNLPEQVRQNEVERIKEYIHIPPFVLTKLCEYAFREILFFLNKKHL 148

Query: 68  KQVAAILHDPEASENDKYVALQFLRNSEIAAKGVLPTCQDTGTAIIVGKKGQRVWTGGGD 127
           KQ++ IL D E+S+NDKYVA+  ++N+ I+A+  LP CQDTGTAII+GKK + + T    
Sbjct: 149 KQLSNILKDGESSKNDKYVAMTLIKNAVISAEQNLPGCQDTGTAIILGKKDEEILTTYE- 207

Query: 128 EETLSKGVYNTYIEDNLRYSQNAALDMYKEVNTGTNLPAQIDLY---------------- 171
            + L+ GVYN Y  +N RYSQ + L M+ E NT  NLP QI++Y                
Sbjct: 208 HKYLNLGVYNAYRNNNFRYSQLSPLSMFSEENTKNNLPCQIEIYSSVRGAKAHGVKTPPG 267

Query: 172 ----------AVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRTLGT 221
                          +Y+ + +AKGGGSANKT+L+Q+TK++L   KL +FL+EK++ +GT
Sbjct: 268 VQLSASSTAPIDSSPKYELIFIAKGGGSANKTFLFQQTKSILNEDKLYDFLLEKIKEIGT 327

Query: 222 AACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLEEAQ 281
           +ACPPYH+A VIGG SAE NLK VKLAS  Y D L  EG  +G+AFRD + E+ +LE+AQ
Sbjct: 328 SACPPYHLAVVIGGLSAEMNLKVVKLASCRYLDNLKKEGGGYGKAFRDTKSEEIILEKAQ 387

Query: 282 KLGLGAQFGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINREGIWIEKLEHN 341
            LG+GAQFGGKYF HD+RVIRLPRH ASCP+G+GVSCSADR IK  INREG+++E LEH+
Sbjct: 388 ALGIGAQFGGKYFVHDVRVIRLPRHSASCPIGIGVSCSADRQIKCLINREGVFMEALEHD 447

Query: 342 PGQYIPQ-----------------ELRQA--------GEGEAVKVDLNRPMKEILAQLSQ 376
           P +Y+P+                     A             V ++LN+PM+ IL  LS+
Sbjct: 448 PIKYLPEITYNDLKQIGGVATRTGGDDHAKNETGEGLPGEGGVPINLNQPMESILKCLSE 507

Query: 377 YPVSTRLSLTGTIIVGRDIAHAKLK-ELIDAGKELPQYIKDHPIYYAGPAKTPAGYPSGS 435
           +PVST L L+G +IV RD AH ++  + +  G  +P+Y K  PIYYAGPAKTP  Y SGS
Sbjct: 508 HPVSTLLLLSGKLIVARDTAHKRIVDDFVMRGIPIPEYFKKFPIYYAGPAKTPDNYASGS 567

Query: 436 LGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHGGFYLGSIGGPAAVLAQQ 495
            GPTTAGRMD+Y ++L  +G S+I LAKGNRS  V  AC K+ GFYLGSIGGP A+LA++
Sbjct: 568 FGPTTAGRMDAYAEVLMKNGASLISLAKGNRSSVVRSACKKYHGFYLGSIGGPGAILAKK 627

Query: 496 SIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQIVN 540
           +IK +E + + ELGMEA+  I+V DFPAFI++DDKGNDF+ + + 
Sbjct: 628 NIKKVEVIDFAELGMEAVHLIDVVDFPAFIVIDDKGNDFYNKWIP 672


>UniRef50_A0KKZ8 Fumarate hydratase, class I n=388 Tax=cellular organisms
           RepID=A0KKZ8_AERHH
          Length = 598

 Score =  502 bits (1293), Expect = e-140,   Method: Composition-based stats.
 Identities = 148/527 (28%), Positives = 242/527 (45%), Gaps = 29/527 (5%)

Query: 32  ADFDGETILKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFL 91
                + +  ++ +        A    S+   P    Q A   +D E +   K    Q L
Sbjct: 85  TRTSEDDMSIIKKQDFIDSIADALQYISYY-HPLDFVQAAKAAYDREINPAAKDALAQIL 143

Query: 92  RNSEIAAKGVLPTCQDTGTAIIVGKKGQRVWTGGGD--EETLSKGVYNTYIE--DNLRYS 147
            NS ++A+G  P CQDTG      K G +V        +E + +G    Y    + LR S
Sbjct: 144 INSRMSAEGHRPLCQDTGIVTCFVKIGMQVQWDSDMTVQEMVDEGTRRAYTNPDNPLRAS 203

Query: 148 QNAALDMYKEVNTGTNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGK 207
              A       NT  N PA + +  + GD+ +    AKGGGS NK+ +     +      
Sbjct: 204 VL-ADPAGSRKNTKDNAPAVVHIDMIPGDKVEVSIAAKGGGSENKSKMVMLNPSD----D 258

Query: 208 LKNFLVEKMRTLGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAF 267
           +  ++++ + T+G   CPP  +   IGGT+ +  +   +    H       E    G   
Sbjct: 259 VVEWVLKTVPTMGAGWCPPGMLGIGIGGTAEKAAVLAKEALMEHID---IQELIARGPQT 315

Query: 268 RDVQLEQELLEEAQKLGLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKA 326
            + +L  EL ++  KLG+GAQ  GG     D++V   P H AS PV M  +C+A R++  
Sbjct: 316 TEEKLRVELYDKVNKLGIGAQGLGGLTTVLDVKVKSAPTHAASKPVVMIPNCAATRHVHF 375

Query: 327 KINREG---IWIEKLEHNPGQYIPQELRQAGEGEAVKVDLNRPMKEILAQLSQYPVSTRL 383
           +++  G   +   KLE  P      E+ ++  G   +V+++   K   A+L+ +     +
Sbjct: 376 ELDGSGPAELTPPKLEDWP------EITRSAGGNVRRVNVDGITK---AELASWKSGDTV 426

Query: 384 SLTGTIIVGRDIAHAKLKELIDAGKELP--QYIKDHPIYYAGPAKTPAGYPSGSLGPTTA 441
            L+G I+ GRD AH ++ +++  G+ LP      +  IYY GP         G  GPTT+
Sbjct: 427 LLSGKILTGRDAAHKRIADMLKKGEGLPEGVDFTNRFIYYVGPVDAVRDEVVGPAGPTTS 486

Query: 442 GRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHGGFYLGSIGGPAAVLAQQSIKHLE 501
            RMD + D++    G + M+ K  R  +  ++  +H   YL ++GG AA L  ++IK   
Sbjct: 487 TRMDKFTDMMLGETGLIGMIGKSERGLKTVESIKQHQAVYLMAVGG-AAYLVAKAIKKAR 545

Query: 502 CVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQIVNKQCANCTK 548
            VA+ +LGMEAI++ EVED P  + VD +GN+  +       A   +
Sbjct: 546 VVAFADLGMEAIYEFEVEDMPVTVAVDSQGNNIHETGPAYWSAKIAE 592


>UniRef50_Q04718 Fumarate hydratase class I, aerobic n=112 Tax=Bacteria
           RepID=FUMA_BACST
          Length = 514

 Score =  486 bits (1251), Expect = e-135,   Method: Composition-based stats.
 Identities = 125/526 (23%), Positives = 197/526 (37%), Gaps = 42/526 (7%)

Query: 45  EALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAKGVLPT 104
           E L     Q   + S  L    ++ +        A             N ++A + V P 
Sbjct: 2   EKLYESMYQLIVETSTKLPKDVRRAILKAKQRENAGTRAAMSLATITENIKMADENVSPI 61

Query: 105 CQDTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEVNTGTNL 164
           CQDTG      K    +      +ET+ K +     +  LR +     D     N+G NL
Sbjct: 62  CQDTGLPTFKIKVPVGI-NQIQIKETIKKAIAQATKDGKLRPNSV---DSLTGENSGDNL 117

Query: 165 P---AQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQET---KALLTPGK----LKNFLVE 214
                 +     + D      + KGGG  NK   Y      + L   G+    ++  ++ 
Sbjct: 118 GEGLPVVKFEQWEKDYMDVRLILKGGGCENKNIQYSLPCELEGLGRAGRDLDGIRKCILH 177

Query: 215 KMRTLGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQ 274
            +       C    I   IGG           LA    +     E ++        QLE+
Sbjct: 178 AVYQAQGQGCSAGFIGVGIGGD----RSAGYDLAKEQLFR----EVDDVNPNEELRQLEE 229

Query: 275 ELLEEAQKLGLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINREGI 333
            ++E A KLG+G   FGG+      +V  + R  AS  V +  +C A R +   I+    
Sbjct: 230 YIMENANKLGIGTMGFGGETTLLGCKVGAMHRIPASFFVSVAYNCWAFRRLGVHIDPNTG 289

Query: 334 WIEKLEHNPGQYIPQELRQAGEG-------EAVKVDLNRPMKEILAQLSQYPVSTRLSLT 386
            I K  +  G+ +  +   A E        E   + L  P+ E   Q+ +  V   + + 
Sbjct: 290 EIIKWLYQDGEDVDFQENAAQEEHLASTDSERRVITLQAPITE--EQIRELKVGDVVRIN 347

Query: 387 GTIIVGRDIAHAKLKELIDAGKELPQYIKDHPIYYAGPAKTPA---GYPSGSLGPTTAGR 443
           G I  GRD  H  L +      + P  +    IY+ GP         +   + GPTT+ R
Sbjct: 348 GIIYTGRDAIHKYLMDH-----DAPVDLNGQIIYHCGPVMLKDENGNWEVKAAGPTTSIR 402

Query: 444 MDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHGGFYLGSIGGPAAVLAQQSIKHLECV 503
            + Y   +    G   ++ KG   Q+   A  +HGG YL +IGG A   A   I+ +E V
Sbjct: 403 EEPYQGDIMKKFGIRAVMGKGGMGQKTLQALKEHGGVYLNAIGGAAQYYA-DCIEAVEGV 461

Query: 504 AYPELG-MEAIWKIEVEDFPAFILVDDKGNDFFQQIVNKQCANCTK 548
              E G  EA+W + V+DF A + +D  GN   + I        ++
Sbjct: 462 DLLEFGIPEAMWHLRVKDFTAVVTMDSHGNSLHEDIEKSSLEKLSQ 507


>UniRef50_D2M1S7 Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit
           n=2 Tax=Bacillus RepID=D2M1S7_BACS4
          Length = 508

 Score =  475 bits (1222), Expect = e-132,   Method: Composition-based stats.
 Identities = 115/521 (22%), Positives = 193/521 (37%), Gaps = 37/521 (7%)

Query: 45  EALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAKGVLPT 104
           E           + S  L    ++ +                      N ++A   +LP 
Sbjct: 2   EKFRQSIYDLIVETSTNLPYDVRRAIRKAKERENEGTRAALSLSTITNNIDMADDNILPI 61

Query: 105 CQDTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEVNTGTNL 164
           CQDTG      K           E+ + + +     +  LR +     D     N+G N+
Sbjct: 62  CQDTGMLTFEIKVPVG-ANQLEMEKDIFEAIRQATKDGKLRPNSV---DSLTGENSGDNI 117

Query: 165 PA---QIDLYAVDGDEYKFLCVAKGGGSANKTYLY---QETKALLTPGK----LKNFLVE 214
                 I  +  + D      + KGGG  NK   Y    E + L   G+    ++  ++ 
Sbjct: 118 GPGTPIIHFHQWEEDYIDARLIVKGGGCENKNIQYSLPMEIEGLGRAGRDLDGIRKCILH 177

Query: 215 KMRTLGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQ 274
            +       C    I   IGG      +   +LA    +     E N+  +  +   LE+
Sbjct: 178 SVYQAQGQGCSAGFIGVGIGGD----RISGYELAKKQLFR----EVNDVNENEKLQALEE 229

Query: 275 ELLEEAQKLGLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINREGI 333
            ++E+   LG+G   FGG+      ++  + R  AS  V +  +C A R +   ++    
Sbjct: 230 YIMEKGNTLGIGTMGFGGEATLLGCKIGTMNRLPASFFVSVAYNCWAFRRLGVTLDASTG 289

Query: 334 WIEKLEHNPGQYIPQELRQAG--EGEAVKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIV 391
            I+   +  G+ I  +  +A        +V L  P+ E   Q+    V   + + G +  
Sbjct: 290 EIQSWLYKEGEKISFKDDEAAATSEGTREVVLEAPITE--EQIRDLKVGDVVVINGDLHT 347

Query: 392 GRDIAHAKLKELIDAGKELPQYIKDHPIYYAGPAKTPA---GYPSGSLGPTTAGRMDSYV 448
           GRD  H  L E      + P  +    IY+ GP         +   + GPTT+ R + Y 
Sbjct: 348 GRDAIHHHLME-----NDAPIDLNGQVIYHCGPVMLKDKDGEWHVKAAGPTTSIREEPYQ 402

Query: 449 DLLQSHGGSMIMLAKGNRSQQVTDACHKHGGFYLGSIGGPAAVLAQQSIKHLECVAYPEL 508
             +    G   ++ KG    +   A  +HGG YL +IGG A   A   IK +E V   E 
Sbjct: 403 GDIMKKFGIRAVIGKGGMGPKTLKALEEHGGVYLNAIGGAAQYYA-DCIKKVEGVDLMEF 461

Query: 509 G-MEAIWKIEVEDFPAFILVDDKGNDFFQQIVNKQCANCTK 548
           G  EA+W ++VE F A + +D  GN   + +         +
Sbjct: 462 GIPEAMWHLKVEGFRAIVTMDSHGNSLHKDVDKTSFERLQQ 502


>UniRef50_A8AAA8 Fumarase n=10 Tax=Archaea RepID=A8AAA8_IGNH4
          Length = 492

 Score =  461 bits (1187), Expect = e-128,   Method: Composition-based stats.
 Identities = 129/513 (25%), Positives = 205/513 (39%), Gaps = 36/513 (7%)

Query: 45  EALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAKGVLPT 104
           + +     +A   A   L     +++       E     K      L N E+A K   P 
Sbjct: 4   DEVVNAVVEAIRLAETALPKWVYEKLLDAYERSE--GLGKAQLAAILNNIELAVKEKKPM 61

Query: 105 CQDTGTAIIVGKKGQRVWT-GGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEVNTGTN 163
           CQDTG        G          EE L + V     E  +R +     D     N G N
Sbjct: 62  CQDTGLMTFDVIVGDEFPIKPYEIEELLKEAVRRATREVPIRPNSV---DPLSGHNPGDN 118

Query: 164 LP---AQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRTLG 220
           +       ++  V G+        KGGGS   + L     +    G ++  +++ +   G
Sbjct: 119 VGKGVPVTNIKVVPGNTLLIKVRPKGGGSEYPSNLCMIPPSKGLEG-VRECVLKAVFEAG 177

Query: 221 TAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLEEA 280
              CPP  +    GGT  E    T KLA    Y        E  +  R  ++E+ELL+E 
Sbjct: 178 GKPCPPGIVGVAFGGTVEE----TAKLAKEALYRP------EAHEEERVARIEKELLDEV 227

Query: 281 QKLGLGAQFGGKY-FAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINREGIWIEKLE 339
             LGLG    G    A  +R     RH AS PV +  +C A R    ++N +G W  KL 
Sbjct: 228 NSLGLGPMGLGGGPTALAVRADYAYRHPASFPVAVRFNCWAAREAVVEVNADGSW--KLV 285

Query: 340 HNPGQYIPQELRQAGEGEAVKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAK 399
            +     P++L+         V++  P++E   ++ +      + LTGT++  RD AH K
Sbjct: 286 SD--NVTPEDLKTPPLEAEDGVEIKLPVEE--EEVRKLKAGDVVYLTGTVVTARDEAHKK 341

Query: 400 LKELIDAGKELPQYIKDHPIYYAGPAKTPAG--YPSGSLGPTTAGRMDSYVDLLQSHGGS 457
           + E     +  P  +K   IY+ GP  T     +   + GPTT+ RM++    +    G+
Sbjct: 342 IIE-----EGAPLDLKGLAIYHCGPVVTKEEGRWKVVAAGPTTSARMNALQAQVLEKTGA 396

Query: 458 MIMLAKGNRSQQVTDACHKHGGFYLGSIGGPAAVLAQQSIKHLECVAYPELG-MEAIWKI 516
            +++ KG   + + D   + G  YL   GG A + A+            ELG  EA+W  
Sbjct: 397 RLVIGKGGMKEDLLDFFKRFGAAYLAFPGGAALLAAKAIKAVRGVYWLEELGIPEAMWVF 456

Query: 517 EVEDF-PAFILVDDKGNDFFQQIVNKQCANCTK 548
           EVE F P  + +D  G   ++++  +      +
Sbjct: 457 EVEKFGPLVVAMDSHGRSLYKEVSERAKTKLEE 489


>UniRef50_C8PSZ3 Fumarate hydratase class I, anaerobic n=1 Tax=Treponema vincentii
           ATCC 35580 RepID=C8PSZ3_9SPIO
          Length = 567

 Score =  455 bits (1172), Expect = e-126,   Method: Composition-based stats.
 Identities = 234/546 (42%), Positives = 310/546 (56%), Gaps = 50/546 (9%)

Query: 40  LKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAK 99
           L V+   L    +QAF   SF     H + +  +  DP +SEND+ VA++ L N+ IAAK
Sbjct: 21  LTVDGSVLAAFTEQAFKRLSFTFPQEHLESLVDVACDPASSENDRLVAVKLLENAVIAAK 80

Query: 100 GVLPTCQDTGTAIIVGKKGQRVWTG----------GGDEETLSKGVYNTYIEDNLRYSQN 149
           G LP CQDTG A +   K   V T           G DEE  + GV   Y E+NLR+S N
Sbjct: 81  GTLPLCQDTGVAQVFAWKDAGVCTALTAAGGTVHFGSDEEAFTAGVGKAYKENNLRFSIN 140

Query: 150 AALDMYKEVNTGTNLPAQIDLYAVDG-----------------------DEYKFLCVAKG 186
               ++ E N+ TNLPAQ+D+++ +G                         Y+FL  AKG
Sbjct: 141 IPSSLFDEKNSATNLPAQVDIFSTNGAGTGTAEYAGSSCSNGTGSDSTEPSYRFLFCAKG 200

Query: 187 GGSANKTYLYQETKALLTPGKLKNFLVEKMRTLGTAACPPYHIAFVIGGTSAETNLKTVK 246
           GGS+NKT     TKALL P   + FL  K+  LGTAACPPY IA VIGG S E NL+T+K
Sbjct: 201 GGSSNKTDFTCATKALLNPQSFERFLKTKIAALGTAACPPYTIAVVIGGLSPEQNLQTLK 260

Query: 247 LASAHYYDELPTEGNEHG-----------QAFRDVQLEQELLEEAQKLGLGAQFGGKYFA 295
           LA+  Y+D         G           +  R    E+ +L+ A + GLGAQFGG + A
Sbjct: 261 LATTGYWDAAEALNKIGGSIRWTDTAGGVRPLRCRDWEERVLQIAAETGLGAQFGGSHLA 320

Query: 296 HDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINREGIWIEKLEHNPGQYIPQELRQAGE 355
              RV RLPRHGASC   +GVSC+A RN+   I+REG +++K   +P  +  +       
Sbjct: 321 AHARVFRLPRHGASCFASIGVSCNAHRNLVGYISREGAFLQKNVSDPRPFFEKAATYTAH 380

Query: 356 -----GEAVKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKEL 410
                GE V V+L+  +    A LS+YPV      +G I+V RD AHA+ K L+++GK L
Sbjct: 381 TAAHHGEPVAVELSS-IDAARAALSKYPVGQAFLFSGEILVARDAAHARWKALLESGKPL 439

Query: 411 PQYIKDHPIYYAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQV 470
           P Y   +PI YAGPA+TP G   GS GPTTA RMD Y D L S G ++I +AKGNRS+  
Sbjct: 440 PDYTLHYPILYAGPAETPKGAVIGSFGPTTANRMDPYADDLMSRGAALITIAKGNRSELW 499

Query: 471 TDACHKHGGFYLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDK 530
             AC K+G FYLG+IGG AA++A++ I   + + YP+LGMEA+  I V+D P F++ DDK
Sbjct: 500 RTACKKYGAFYLGTIGGAAALIAEKHITARKVLDYPDLGMEAVQLISVKDLPVFLITDDK 559

Query: 531 GNDFFQ 536
           GNDF+ 
Sbjct: 560 GNDFYA 565


>UniRef50_B1B7A5 Fumarase n=4 Tax=Bacteria RepID=B1B7A5_CLOBO
          Length = 279

 Score =  346 bits (889), Expect = 9e-94,   Method: Composition-based stats.
 Identities = 84/291 (28%), Positives = 129/291 (44%), Gaps = 13/291 (4%)

Query: 39  ILKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAA 98
           + ++  + +T   +     A++ L     K      ++ E S   K +  Q ++N  IAA
Sbjct: 1   MREINAQQITSAVKDIAIKANYFLGNDVIKA-LKDRYEKEESPVGKEILNQIMKNDNIAA 59

Query: 99  KGVLPTCQDTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEV 158
              +P CQDTG A++  + GQ V   G   + +++GV   Y E  LR S     +     
Sbjct: 60  SEHMPICQDTGVAVVFIELGQEVHVNGDISKAINEGVRQGYKEGYLRKSIVE--NPLYRK 117

Query: 159 NTGTNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRT 218
           NT  N PA I +  V GD+ K     KGGGS N + +          G +K F+VE +  
Sbjct: 118 NTSDNTPAVIYMKVVSGDKIKITIAPKGGGSENMSRIKMLKPLEGKEG-VKKFVVETISE 176

Query: 219 LGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLE 278
            G   CPP  +   IGGT  +  L   +         L     +  +  R   LE ELLE
Sbjct: 177 AGGNPCPPIVVGVGIGGTFEKAALMAKEA--------LLRPIYDQNKDTRIANLECELLE 228

Query: 279 EAQKLGLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKI 328
           E  KLG+G    GG+  +  +++   P H AS PV + ++C A R+    +
Sbjct: 229 EINKLGIGPMGLGGRTTSLAVKINTYPCHIASLPVAININCHAARHETIVL 279


>UniRef50_B2TIL9 Fumarate hydratase n=6 Tax=Clostridia RepID=B2TIL9_CLOBB
          Length = 280

 Score =  340 bits (873), Expect = 8e-92,   Method: Composition-based stats.
 Identities = 88/292 (30%), Positives = 130/292 (44%), Gaps = 14/292 (4%)

Query: 39  ILKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAA 98
           + +V  + +    ++    A++ L     +Q      D E     + +  + + NSEIA 
Sbjct: 1   MREVNVDCIIDAVKELSIKANYFLG-EDIRQALEDSRDKETWNLAEDILDKIIINSEIAD 59

Query: 99  KGVLPTCQDTGTAIIVGKKGQRVW-TGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKE 157
           K  +P CQDTG A +  + GQ V   GG   E +++GV   Y E  LR S     +  K 
Sbjct: 60  KEHVPICQDTGMACVFVELGQDVHLIGGNLSEAINEGVRMGYEEGFLRKSVVE--NPLKR 117

Query: 158 VNTGTNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMR 217
           +NT  N PA I    V GD+ K     KG GS N + +     +    G +K F++E +R
Sbjct: 118 INTNDNTPAVIYYDIVPGDKIKITVAPKGFGSENMSKITMLKPSDGVEG-VKEFILEVVR 176

Query: 218 TLGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELL 277
             G   CPP  I   IGGT  ++     K         L    N          LE ELL
Sbjct: 177 QAGPNPCPPMVIGVGIGGTFDKSAYLAKKA--------LLRPINIRNDDEYYKDLEIELL 228

Query: 278 EEAQKLGLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKI 328
           E+  +LG+G Q FGG+  A  + +   P H A  PV + ++C A R+ +  I
Sbjct: 229 EKINELGIGPQGFGGRTTALGLNIETYPTHIAGLPVAVNINCHATRHKEIII 280


>UniRef50_B4SZG5 Fumarate hydratase n=21 Tax=Salmonella enterica RepID=B4SZG5_SALNS
          Length = 281

 Score =  333 bits (855), Expect = 8e-90,   Method: Composition-based stats.
 Identities = 83/291 (28%), Positives = 120/291 (41%), Gaps = 14/291 (4%)

Query: 40  LKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAK 99
             +  E +  + ++    A + L   +        +D E S+  K      + N E A K
Sbjct: 3   RILNTEIIIPVIEKLVKKACYELD-DNLMCSFRKAYDKEESKIGKETIKILIDNGEYAKK 61

Query: 100 GVLPTCQDTGTAIIVGKKGQRVWTGG-GDEETLSKGVYNTYIEDNLRYSQNAALDMYKEV 158
             L  C DTGT I++ + GQ V   G   ++ +++GV   Y    LR S  A  D  + +
Sbjct: 62  EQLACCHDTGTCIVIMEIGQHVCWEGKPLKDQVNQGVRQGYENGYLRKSMVA--DPLERI 119

Query: 159 NTGTNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRT 218
           NT  N PA +    VDGD      + KGGGS N              G +K+F++E +R 
Sbjct: 120 NTNDNTPAILHTEIVDGDRVTITVMPKGGGSENMGTFKTLLPGDGIDG-IKDFVLETVRR 178

Query: 219 LGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLE 278
           +G   CPPY I   +GGT    +    K         L     E        QLE ELLE
Sbjct: 179 VGGNPCPPYIIGIGVGGTMDHCSWMAKKA--------LLRPLGEFNAKPLYAQLEAELLE 230

Query: 279 EAQKLGLGA-QFGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKI 328
                G+G    GG+  A  + V   P H  + PV +   C+A R+    I
Sbjct: 231 AVNNTGIGPLGMGGRITALGVHVDYYPCHITALPVAINFQCNASRHASEII 281


>UniRef50_B1I426 Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit
           n=135 Tax=cellular organisms RepID=B1I426_DESAP
          Length = 294

 Score =  329 bits (844), Expect = 2e-88,   Method: Composition-based stats.
 Identities = 82/292 (28%), Positives = 124/292 (42%), Gaps = 14/292 (4%)

Query: 39  ILKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAA 98
           +  ++ E +     +   +A+++L P             E S   K V  Q L N+ IA 
Sbjct: 15  VRTLDCEKVVEATSRLCREANYVLEPDVV-AALEGARQEEVSPTGKDVLGQLLENARIAV 73

Query: 99  KGVLPTCQDTGTAIIVGKKGQRV-WTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKE 157
           +  +P CQDTG A++  + GQ +   GG  EE + +GV   Y +  LR S  A  D    
Sbjct: 74  REEIPLCQDTGIAVVFVEVGQDLRIVGGSLEEAVVRGVREGYEQGYLRKSVVA--DPLNR 131

Query: 158 VNTGTNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMR 217
           VNTG N P  I    V GD  K   + KG GS N + L     A    G +K F++E + 
Sbjct: 132 VNTGDNSPPVIHWRLVPGDRLKISVMPKGAGSENMSALKMLKPAEGLDG-VKRFILETVS 190

Query: 218 TLGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELL 277
           + G   CPP  +   +GGT  +  L           + L              +LE+ L 
Sbjct: 191 SAGPNPCPPLVVGVGLGGTMEKAALLAK--------EALLRPLGTRNPVAELAELEENLR 242

Query: 278 EEAQKLGLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKI 328
               +LG+G    GG+     + +   P H A  PV + ++C A R+  A +
Sbjct: 243 VFLNELGIGPMGLGGRVTVLAVHLSTYPTHIAMLPVAVNLNCHAVRHKTAVL 294


>UniRef50_Q312U0 Fumarase alpha subunit n=1 Tax=Desulfovibrio desulfuricans subsp.
           desulfuricans str. G20 RepID=Q312U0_DESDG
          Length = 279

 Score =  328 bits (841), Expect = 4e-88,   Method: Composition-based stats.
 Identities = 85/292 (29%), Positives = 128/292 (43%), Gaps = 15/292 (5%)

Query: 39  ILKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAA 98
           +  ++   L    +    DA+ +L               E +++ K V  Q L N+++AA
Sbjct: 1   MKSIKAADLHAAVRDMIMDANRVLGKDV-YNAFQTCMQQETTDSGKEVLRQLLENADLAA 59

Query: 99  KGVLPTCQDTGTAIIVGKKGQRVWT-GGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKE 157
           +  L  CQDTG A+   + G+ V   GGG +ETL+  +   Y +  LR S          
Sbjct: 60  QSGLALCQDTGVAVFFVEMGEEVRMEGGGLKETLNAAMVEAYNKAFLRKSMCHP---LTR 116

Query: 158 VNTGTNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMR 217
            NTG N PA I +  V GD  K   +AKGGGS N +     T A    G +K+F+V +M 
Sbjct: 117 KNTGDNTPAVIHVELVPGDTLKVRYMAKGGGSENMSRCTMLTPAQGWQG-IKDFVVRRMA 175

Query: 218 TLGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELL 277
             G   CPP  +   IGGT          LA    +       ++         +E+ELL
Sbjct: 176 EAGPNPCPPTIVGVGIGGTFD----LAPSLAKGALFR----RVDDVHPDPEIAAMEKELL 227

Query: 278 EEAQKLGLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKI 328
           +E   LG+G    GGK     +++   P H AS P+ + V C + R+ +   
Sbjct: 228 DEINALGIGPMGLGGKTTCLAVKIAMHPCHIASLPLAVNVQCHSSRHKEVVF 279


>UniRef50_Q1LBZ5 Fumarase alpha subunit n=20 Tax=Bacteria RepID=Q1LBZ5_RALME
          Length = 280

 Score =  324 bits (832), Expect = 4e-87,   Method: Composition-based stats.
 Identities = 82/292 (28%), Positives = 124/292 (42%), Gaps = 14/292 (4%)

Query: 39  ILKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAA 98
           + ++  + LT    +   DA   L P +  +      + E S   K V ++ + N  IA 
Sbjct: 1   MREIHVDTLTDAVAKLCIDACHRL-PDNLVESFHKAAEKEVSPLGKSVLMKLIDNDRIAR 59

Query: 99  KGVLPTCQDTGTAIIVGKKGQRVWT-GGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKE 157
           +  +  C DTG AI+  + GQ V   GG  E+ +  GV   Y E  +R S  +  D    
Sbjct: 60  ENDVSYCHDTGLAIVFVEVGQDVHIVGGSYEDAIQAGVRKGYAEGYMRKSVVS--DPLLR 117

Query: 158 VNTGTNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMR 217
           VN+  N PA +    V GD  +   V KGGGS N + +          G +K F++  + 
Sbjct: 118 VNSNDNTPAVVHTEIVPGDNIEVTVVPKGGGSENWSTMKFLLPGEGAEG-VKKFVLSAIE 176

Query: 218 TLGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELL 277
             G AACPP  +   IGG+  +      K         +  +   H +     +LE ELL
Sbjct: 177 AAGGAACPPLTVGVGIGGSFDKVTAIAKKA--------ILRDIGVHHKEPHVAKLEAELL 228

Query: 278 EEAQKLGLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKI 328
           +   K G+G Q +GG   A  + V     H  + PV + + C A R   A I
Sbjct: 229 DAINKTGIGPQGYGGVNTALWVSVETYACHITALPVAVNIQCHAGRRATAVI 280


>UniRef50_Q469V4 Fumarase alpha subunit n=6 Tax=Archaea RepID=Q469V4_METBF
          Length = 280

 Score =  321 bits (822), Expect = 6e-86,   Method: Composition-based stats.
 Identities = 77/295 (26%), Positives = 108/295 (36%), Gaps = 23/295 (7%)

Query: 41  KVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAKG 100
           K+  E+               L P             E ++  K+     L+N EIA K 
Sbjct: 4   KISRESFIRSIADLLRKTETEL-PDDVVNAIRKAEAAEENKVAKFQLRAILKNLEIAKKY 62

Query: 101 VLPTCQDTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEVNT 160
            +P CQDTG  I   + G     G   E  + + V     E  LR +     D     N+
Sbjct: 63  RVPMCQDTGIMIFFAEIGSEFQPGFDLEAAIREAVILATTEIPLRPNAV---DPLTRKNS 119

Query: 161 GTNLP---AQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMR 217
           G N       I    V G++ K     KG GS N + L          G +KNF++E + 
Sbjct: 120 GNNTGVGIPDIHWKLVPGNQLKITAAPKGAGSENMSSLRMFNPTE--TGSIKNFVLETIV 177

Query: 218 TLGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELL 277
           T G   CPP  I   IGG+         +LA     + L               LE+E+ 
Sbjct: 178 TAGGMPCPPLTIGIGIGGSFDAAA----RLAKESLLEPLDAP---------MEGLEREIF 224

Query: 278 EEAQKLGLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINRE 331
           E    LG+G    GG   A  +RV     H AS PV + + C A+R+       +
Sbjct: 225 EAVNTLGIGCMGLGGSTTALAVRVKTAHCHTASLPVAVNIQCWANRHASVVFGGD 279


>UniRef50_B1GZT9 Fumarate hydratase alpha subunit n=1 Tax=uncultured Termite group 1
           bacterium phylotype Rs-D17 RepID=B1GZT9_UNCTG
          Length = 279

 Score =  320 bits (821), Expect = 6e-86,   Method: Composition-based stats.
 Identities = 81/292 (27%), Positives = 124/292 (42%), Gaps = 15/292 (5%)

Query: 39  ILKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAA 98
           + K++ E +    +    + +F L     K +   +      +  K +  + + N++IA 
Sbjct: 1   MRKIKSEIIINAIENLCAETNFKLPADVLKSLEQNIVL--EKDTAKDILKEIIENADIAR 58

Query: 99  KGVLPTCQDTGTAIIVGKKGQRVWTG-GGDEETLSKGVYNTYIEDNLRYSQNAALDMYKE 157
           K  +P CQDTGTA    K G+      G     ++KGV   Y    LR S   A +  + 
Sbjct: 59  KEQIPLCQDTGTANFFIKLGRDTEIENGDIYAAVNKGVSLGYTNSYLRKSV--ASNPLER 116

Query: 158 VNTGTNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMR 217
            NT  N PA I +  V GD+ +   + KGGGS N + L     ++   G ++ F++  + 
Sbjct: 117 KNTKDNTPANIYIDLVSGDKIEITFLPKGGGSENASALKMLVPSVGWDG-IREFVLSAVD 175

Query: 218 TLGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELL 277
             G  ACPP  +   IGG  A   L + K         L  E     +    V  E ELL
Sbjct: 176 DKGRNACPPLVVGIGIGGDFASVGLMSKKA--------LLREIGSENKNVFYVGKEMELL 227

Query: 278 EEAQKLGLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKI 328
            +  KL +G    GGK  A  + +   P H AS PV + + C + R     I
Sbjct: 228 NDINKLNIGPMGMGGKTTALAVFIEAKPVHIASLPVAVNIQCHSCRRKTVMI 279


>UniRef50_A6Q389 Fumarate/tartrate hydratase, alpha subunit n=9 Tax=Bacteria
           RepID=A6Q389_NITSB
          Length = 287

 Score =  314 bits (805), Expect = 5e-84,   Method: Composition-based stats.
 Identities = 84/300 (28%), Positives = 118/300 (39%), Gaps = 23/300 (7%)

Query: 39  ILKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAA 98
           +  V  E +    +     ++  L      +      + E S   K V  Q L N+EIAA
Sbjct: 1   MRTVAYEDIVKAIRDTIIYSTTHLS-EDMHKALQEALEKEESLVSKAVLEQLLENAEIAA 59

Query: 99  KGVLPTCQDTGTAIIVGKKGQRVWTGGG-DEETLSKGVYNTYIEDNLRYSQNAALDMYKE 157
               P CQDTG AI   K G+ V   GG  +E + +G    Y E  LR S     D +  
Sbjct: 60  SENKPLCQDTGLAIFFVKVGEDVRVEGGSLKEAIFEGTKKGYEEGYLRASTC---DCFTR 116

Query: 158 VNT----GTNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLV 213
            N     G NLP  I    V GD+ +    AKGGGS N +       A    G +K F+ 
Sbjct: 117 ANLKDKIGYNLPPVIYFDIVPGDKIEIEFAAKGGGSENGSRARVLAPAQGKEG-IKEFVK 175

Query: 214 EKMRTLGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLE 273
           + +   G   CPP  +   IGG+     + +           L  +             E
Sbjct: 176 QVVSDAGPNVCPPIVVGVGIGGSFDYAAVMSKHA--------LFRDIGTPNPDPELDAFE 227

Query: 274 QELLEEAQKLGLGAQ-FGGKYFAHDIRVIRLP----RHGASCPVGMGVSCSADRNIKAKI 328
           +E+LEE  KLG+GA   GG   A  + +         H AS PV + + C + R+    I
Sbjct: 228 KEILEELNKLGIGAMGMGGTQTALAVHIETYKPGRMCHIASLPVAVNIQCHSSRHAHITI 287


>UniRef50_A6T6H6 Tartrate dehydratase n=1 Tax=Klebsiella pneumoniae subsp.
           pneumoniae MGH 78578 RepID=A6T6H6_KLEP7
          Length = 281

 Score =  313 bits (803), Expect = 8e-84,   Method: Composition-based stats.
 Identities = 80/291 (27%), Positives = 120/291 (41%), Gaps = 14/291 (4%)

Query: 40  LKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAK 99
             +  E +  + ++    A + L   +        ++ E S+  K      + N E A K
Sbjct: 3   RILNTEVIVPVIEELVKKACYELD-DNLMCAFRKAYEKEESKLGKETIKILIDNGEYAKK 61

Query: 100 GVLPTCQDTGTAIIVGKKGQRVWTGG-GDEETLSKGVYNTYIEDNLRYSQNAALDMYKEV 158
             L  C DTGT I++ + GQ V   G   ++ +++GV   Y +  LR S  A  D    +
Sbjct: 62  EQLACCHDTGTCIVIMEIGQEVCWEGFSLQQQVNQGVRQGYEKGYLRKSMVA--DPLDRI 119

Query: 159 NTGTNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRT 218
           NT  N PA +    V+GD      + KGGGS N              G +K F++E +R 
Sbjct: 120 NTNDNTPAVLHTEIVEGDRVTITVMPKGGGSENMGTFKTLLPGDDIEG-VKRFVLETVRH 178

Query: 219 LGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLE 278
           +G   CPPY I   IGGT         K         L     E+       +LE ELL+
Sbjct: 179 VGGNPCPPYIIGIGIGGTMDHCAWMAKKA--------LLRPIGEYNAKPLYAKLEAELLD 230

Query: 279 EAQKLGLGA-QFGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKI 328
           E    G+G    GG+  A  + +   P H  + PV +   C+A R+    I
Sbjct: 231 EVNNTGIGPLGMGGRVTALGVHIDYYPCHITALPVAINFQCNASRHASKTI 281


>UniRef50_A2BJ70 L(+)-tartrate dehydratase class I, alpha subunit n=7 Tax=cellular
           organisms RepID=A2BJ70_HYPBU
          Length = 294

 Score =  312 bits (799), Expect = 3e-83,   Method: Composition-based stats.
 Identities = 76/298 (25%), Positives = 111/298 (37%), Gaps = 16/298 (5%)

Query: 47  LTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAKGVLPTCQ 106
           L     +    A   L P           + E +   K      LRNSE+AAK   P CQ
Sbjct: 8   LREFLVELIRVAETRL-PLDVYNALKKALEVEDNPIAKQHLEAILRNSELAAKLGKPICQ 66

Query: 107 DTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEVNTGTNLP- 165
           DTGT +   + G+         E  ++ V        LR +    +   +  NTG N   
Sbjct: 67  DTGTPVFYIRLGEEFPLRAKIYEVATEAVREATRLIPLRPNAVNPI---RGGNTGDNTGR 123

Query: 166 --AQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRTLGTAA 223
                D+  V GD  +   VAKGGGS   + L            +   +++ + + G   
Sbjct: 124 HIPWFDVEIVPGDRLEVTFVAKGGGSEAPSTLNMALPIRGIR-NVWETVLKAVVSAGPKP 182

Query: 224 CPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLEEAQKL 283
           CPP  +   I     +      K A       L     E        +LE++LL+    L
Sbjct: 183 CPPVVVGVGIAALGEQALAIARKAA-------LLRPLGERHPEPEIAELEEKLLDAINSL 235

Query: 284 GLGA-QFGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINREGIWIEKLEH 340
           G+G   FGGK  A D+ +    RH A+  VG+  +C A R     I  +G W    +H
Sbjct: 236 GIGVHGFGGKITALDVHIDYAHRHPATYAVGVVFNCWAIRRATGYITPDGRWEITSKH 293


>UniRef50_Q0W345 Fumarate hydratase (Fumarase), alpha subunit n=12 Tax=cellular
           organisms RepID=Q0W345_UNCMA
          Length = 288

 Score =  308 bits (789), Expect = 4e-82,   Method: Composition-based stats.
 Identities = 71/292 (24%), Positives = 102/292 (34%), Gaps = 19/292 (6%)

Query: 47  LTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAKGVLPTCQ 106
           +   A +    A   L               E+ +  K      + N   A +  LP CQ
Sbjct: 7   IEDAAVELIRRAVTRLPAGVI-AELERAERTESQDTPKRELRAMIENVREAGRCTLPMCQ 65

Query: 107 DTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEVNTGTNLP- 165
           DTG  +     G   +   G EE L+  V     E  LR +           NTG N   
Sbjct: 66  DTGIPLFFVTVGS--FRVKGLEEVLAAAVRKATTEVPLRKNVVHP---LTRANTGDNTGT 120

Query: 166 --AQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRTLGTAA 223
               I     D +  +   + KG GS N + L     +    G ++ F+VE +       
Sbjct: 121 DMPHIAYSFHDAEYMEISYMPKGAGSENMSALAMLNPSQGVQG-IRKFVVETIAKAEGKP 179

Query: 224 CPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLEEAQKL 283
           CPP  I   +GG+S        +         L     E        +LE ELLE   + 
Sbjct: 180 CPPVIIGVGLGGSSDMCMAMAKRA--------LLRPVGEKNADPEMAKLEAELLELINRT 231

Query: 284 GLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINREGIW 334
           G+G    GG+  A  + V     H AS PVG+ V C A R    ++  +G  
Sbjct: 232 GVGPMGLGGRTTALAVHVEWASCHTASLPVGLNVQCYAARRATIRVYPDGRT 283


>UniRef50_Q2RG69 Fumarase alpha subunit n=13 Tax=Bacteria RepID=Q2RG69_MOOTA
          Length = 281

 Score =  306 bits (785), Expect = 1e-81,   Method: Composition-based stats.
 Identities = 84/291 (28%), Positives = 115/291 (39%), Gaps = 14/291 (4%)

Query: 40  LKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAK 99
             +  + +T         A++ L     +         E S   K V  Q L N+ IAA 
Sbjct: 3   RIITCDEITRAVADLCRQANYYLG-EDVRGALEGALAREVSPQGKDVLNQLLENAAIAAA 61

Query: 100 GVLPTCQDTGTAIIVGKKGQRVWTGGG-DEETLSKGVYNTYIEDNLRYSQNAALDMYKEV 158
             +P CQDTG A++  + GQ V   GG   + ++ GV   Y E  LR S           
Sbjct: 62  EEVPICQDTGVAVVFLELGQEVQVQGGYLYDAINAGVRQGYTEGYLRKSMVYP--PLDGR 119

Query: 159 NTGTNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRT 218
           NTG N PA I    V GD+       KGGGS N +       A    G +K F++E ++ 
Sbjct: 120 NTGDNTPAIIHTEIVPGDKLTITVAPKGGGSENMSAAVMLAPAAGIRG-VKEFVLETVKK 178

Query: 219 LGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLE 278
            G   CPP  +   IGG   +  L   K         L     E         LE++LLE
Sbjct: 179 AGPNPCPPLIVGVGIGGNFEKCALLAKKA--------LLRPLGEPHPLEGIATLERDLLE 230

Query: 279 EAQKL-GLGAQFGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKI 328
               L      FGG+  A  + V    RH AS PV + + C A R+    +
Sbjct: 231 SINCLGIGPGGFGGRMTALAVHVEIFARHIASLPVAVNIQCHAARHKSITL 281


>UniRef50_Q0RXW8 Fumarate hydratase, class I n=2 Tax=Bacteria RepID=Q0RXW8_RHOSR
          Length = 301

 Score =  305 bits (782), Expect = 3e-81,   Method: Composition-based stats.
 Identities = 72/305 (23%), Positives = 119/305 (39%), Gaps = 20/305 (6%)

Query: 37  ETILKVEPE----ALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLR 92
            T++++ PE     LT L+   +  A   L P  +  V  +     A    +      + 
Sbjct: 4   RTMVELAPESLYRDLTELSAHLYKKALTDLPPDVRSAVHRVAEQEVAG--ARRRLDVMVN 61

Query: 93  NSEIAAKGVLPTCQDTGTAIIVGKKGQRVWTGG-GDEETLSKGVYNTYIEDNLRYSQNAA 151
           + +I+ +  +  CQDTG  +   + G      G      L  GV     + +LR S    
Sbjct: 62  SIDISDRTGIIVCQDTGICVFFVRLGTEFPVNGAKLINALRNGVALATKQHDLRSSIVHP 121

Query: 152 LDMYKE-VNTGTNLPAQIDLYAVDG-DEYKFLCVAKGGGSANKTYLYQETKALLTPGKLK 209
           +       NTG  +P  + +  VDG DE + L V KG GS N +YL   + +    G +K
Sbjct: 122 ITRENRQDNTGVGIP-DVHVEFVDGSDELEILLVPKGSGSENMSYLKMLSPSEGITG-VK 179

Query: 210 NFLVEKMRTLGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRD 269
            F+++ +   G   CPP  +   IGGT+        K         +     E       
Sbjct: 180 RFVLDSVIDAGPRPCPPTVVGVGIGGTADLCAALAKKA--------ILRPVGEPHPEPEI 231

Query: 270 VQLEQELLEEAQKLGLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKI 328
             +E++LL    + G+G Q  GG   +  + V     H +  PV + + C       A I
Sbjct: 232 AAIEKQLLAAINETGIGPQGLGGNVTSFAVHVEYSATHISMNPVAVNIQCWRGERASATI 291

Query: 329 NREGI 333
           + +G 
Sbjct: 292 STDGA 296


>UniRef50_B2KBV3 Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit
           n=2 Tax=Bacteria RepID=B2KBV3_ELUMP
          Length = 279

 Score =  303 bits (776), Expect = 1e-80,   Method: Composition-based stats.
 Identities = 76/291 (26%), Positives = 123/291 (42%), Gaps = 13/291 (4%)

Query: 39  ILKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAA 98
           + +++   +T         A+  L  +              S  +K +   +L+N+ IA 
Sbjct: 1   MRQIKSSDITKTIASLCKQANIELPNSTVCSF--AACAKRCSGREKEIFNIYLKNASIAK 58

Query: 99  KGVLPTCQDTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEV 158
             +LP CQDTG  ++  + G  V   G   + ++KGV   Y ++ LR S      ++  V
Sbjct: 59  GQLLPICQDTGITVVFLEIGVGVLIKGDLYKAVNKGVSLGYKKNFLRASVVK-DPLFGRV 117

Query: 159 NTGTNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRT 218
           NT  N PA I    V G + K   V KG G+ N + L     +      +K+F+V  ++ 
Sbjct: 118 NTKDNTPAVIYTKIVKGSKIKITVVPKGAGAENMSALKMFNPSAPIEE-IKDFIVNTVKQ 176

Query: 219 LGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLE 278
                CPP  +   +GGT                   L  E     +      LE+++L+
Sbjct: 177 ADANPCPPVVVGVGVGGTFDYCAFMAKHA--------LTNEIGRVNKDKNYASLEKDILK 228

Query: 279 EAQKLGLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKI 328
           +  KLG+G Q FGGK  A  + +   P H AS PV + + C   R+ KA +
Sbjct: 229 KINKLGIGPQGFGGKNTALAVFIEHAPCHMASLPVAVNIGCHVHRHAKAVL 279


>UniRef50_B1L7M6 Tartrate dehydratase alpha subunit/Fumarate hydratase class I,
           N-terminal domain protein n=3 Tax=Archaea
           RepID=B1L7M6_KORCO
          Length = 292

 Score =  302 bits (774), Expect = 2e-80,   Method: Composition-based stats.
 Identities = 75/291 (25%), Positives = 125/291 (42%), Gaps = 17/291 (5%)

Query: 46  ALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAKGVLPTC 105
           ++     +   +A+F +    +  +    ++ E +   +      L+N + + K  +P C
Sbjct: 7   SIIDGIVKMMREAAFNVPKDVKDALIK-AYESEDNPVARANLEAILKNIDASGKLKMPMC 65

Query: 106 QDTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEVNTGTNLP 165
           QDTGT     + G         +  + + V     E  LR +     + +   N G N  
Sbjct: 66  QDTGTPTFFIELGDDFPLRSEVKSVIEEAVRRATAEIPLRPNTV---NPWTGENPGDNTG 122

Query: 166 ---AQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRTLGTA 222
                I L  V GD+ + L +AKGGGS N + +Y  +  L   G +K  +++ M   G  
Sbjct: 123 RHVPIIHLDLVPGDQMRVLFLAKGGGSENTSKIYMLSPVLGIKG-IKKAVIDAMIDAGPM 181

Query: 223 ACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLEEAQK 282
            CPP  +   +GG++       +KLA    +  L    NE     +  +LE ELLE    
Sbjct: 182 PCPPIIVGVGVGGSAD----LAIKLAKKATFRRL----NEPNPDPKLNELENELLEMINS 233

Query: 283 LGLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINREG 332
           LG+G    GGK +A  ++V    +H AS PVG+   C A R  +   ++ G
Sbjct: 234 LGIGPMGLGGKTYALGVKVEWAHKHPASLPVGISTQCWAFRRAEGIFDKNG 284


>UniRef50_Q58690 Putative fumarate hydratase subunit alpha n=18 Tax=Euryarchaeota
           RepID=FUMA_METJA
          Length = 285

 Score =  301 bits (770), Expect = 5e-80,   Method: Composition-based stats.
 Identities = 80/291 (27%), Positives = 123/291 (42%), Gaps = 15/291 (5%)

Query: 46  ALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAKGVLPTC 105
            ++ +  + F +A+  L P   K      +  E+SE  K      + N++IA +  +P C
Sbjct: 2   KISDVVVELFREAAIYL-PEDVKNALEEAYKKESSEISKNTLKAIIENNKIAEETQVPLC 60

Query: 106 QDTGTAIIVGKKGQRVWTGG--GDEETLSKGVYNTYIEDNLRYSQNAALDMYK-EVNTGT 162
           QDTG  I+  K G+ + +       E + +GV     E  LR +    L     + N G 
Sbjct: 61  QDTGVPIVFLKIGKNINSSEIMKIIEEIKEGVKKATEEVPLRPNVVHPLTRENFKTNVGL 120

Query: 163 NLPAQ-IDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRTLGT 221
           N P   I+       E + +   KG GS N + L     +    G +KNF++E +   G 
Sbjct: 121 NSPFINIEFDESLDREIEIIAFPKGAGSENMSALKMLKPSDGIEG-IKNFVLETIANAGG 179

Query: 222 AACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLEEAQ 281
             CPP  +   IGGT+                  L  +  E  +      LE+ELLE+  
Sbjct: 180 KPCPPIVVGIGIGGTADVALKLAK--------KALLRKIGERHRDKEIANLEKELLEKIN 231

Query: 282 KLGLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINRE 331
            LG+GA   GG   A D+ +     H AS PVG+ + C ADR    +I  +
Sbjct: 232 SLGIGAMGLGGDITALDVFIEIAGCHTASLPVGICIQCWADRRAIKRIKLD 282


>UniRef50_A2SQV2 Fumarase alpha subunit n=2 Tax=Methanomicrobiales
           RepID=A2SQV2_METLZ
          Length = 273

 Score =  299 bits (765), Expect = 2e-79,   Method: Composition-based stats.
 Identities = 59/285 (20%), Positives = 109/285 (38%), Gaps = 22/285 (7%)

Query: 47  LTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAKGVLPTCQ 106
           L    ++A H A  +L P   ++     ++ E +   +        N ++A +  +P CQ
Sbjct: 8   LASAVEEAIHQAETILPPDV-EEALHTAYNKETNPTARGEFENIFANLQVAREKNVPICQ 66

Query: 107 DTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEVNTGTNLPA 166
           DTG  +I     + V       + +S+G+        LR +           N+G N  A
Sbjct: 67  DTGIFVIYLTIPETVPLTTKLYDAVSEGIRLATKSVPLRPNAVHP---LTRKNSGDNTGA 123

Query: 167 QID-LYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRTLGTAACP 225
            I  ++ + GD  +     KG GS N + +     + ++  ++  F+   ++  G+  CP
Sbjct: 124 GIPAVHILPGDTLRVTVFPKGAGSENMSQIRMMLPSEIS--RIPEFVTSVVKDAGSRPCP 181

Query: 226 PYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLEEAQKLGL 285
           P  +   IGGT         +         L +  N           EQ++ +   +LG+
Sbjct: 182 PIVVGVGIGGTFDSAASFAKEA--------LLSPINS------MTAFEQKICDSINQLGI 227

Query: 286 GAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKIN 329
           G    GG      ++V     H AS PV + + C   R    ++ 
Sbjct: 228 GVMGLGGDTTCLAVKVKEGACHTASLPVAVNIQCWCSRRGVVEVE 272


>UniRef50_A9HYF3 Fumarate hydratase alpha subunit n=3 Tax=Proteobacteria
           RepID=A9HYF3_BORPD
          Length = 292

 Score =  298 bits (764), Expect = 3e-79,   Method: Composition-based stats.
 Identities = 71/298 (23%), Positives = 116/298 (38%), Gaps = 13/298 (4%)

Query: 39  ILKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAA 98
           + +++   +   A++ +  A   L P   KQ    L   E+S+  + +      N  +A 
Sbjct: 1   MSEIDYAQVEDAARELYIRALKRL-PDDIKQGFERLRGAESSDRARSILDTMTTNIAVAE 59

Query: 99  KGVLPTCQDTGTAIIVGKKGQRVWTGGG-DEETLSKGVYNTYIEDNLRYSQNAALDMYK- 156
                 CQDTG  I     G+RV   G   ++ +  G      E  LR S    +     
Sbjct: 60  AHDNLLCQDTGIPIYNVLVGRRVALDGWRLKQAIRAGCERATREHPLRSSVVHPISRKNA 119

Query: 157 EVNTGTNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKM 216
             + G  +P     +  D + ++   + KG GS N ++L     A      +K F+++ +
Sbjct: 120 HTSCGPGVPVIHVDFCEDDERFEIEMIPKGSGSENNSFLRMAIPAEGLDA-VKTFVIDCV 178

Query: 217 RTLGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQEL 276
              G   CPP  +   +GGTS       V LA       L +  +         QLEQEL
Sbjct: 179 MQAGGKTCPPTIVGVGVGGTSD----LCVHLAKQAATRPLGSRCD----DPLGAQLEQEL 230

Query: 277 LEEAQKLGLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINREGI 333
                +LG+G Q  GG   A  + V     H    PV + + C + R  +A +   G+
Sbjct: 231 SAAVNQLGVGPQGLGGDATAFAVHVELAATHITMNPVAVNMQCHSARRARATLTPNGV 288


>UniRef50_A4YFS7 Fumarase alpha subunit n=1 Tax=Metallosphaera sedula DSM 5348
           RepID=A4YFS7_METS5
          Length = 294

 Score =  296 bits (758), Expect = 1e-78,   Method: Composition-based stats.
 Identities = 65/294 (22%), Positives = 117/294 (39%), Gaps = 19/294 (6%)

Query: 44  PEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAKGVLP 103
              +  +++  ++ A  ++     +++    ++ E SE  + V    ++N E+A K  L 
Sbjct: 7   YSLVEEVSETLYYKALTVIPKDVVERIGK-AYEMEQSELGRRVLDTIMKNIEVATKRNLL 65

Query: 104 TCQDTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEVNTGTN 163
            CQDTGT +   + G    +     +++++GV    ++ +LR +    +      NTG N
Sbjct: 66  VCQDTGTPVYSVELGDFEISLPKLRDSIARGVRKATLKYHLRPNMVHPI---TRENTGDN 122

Query: 164 LP---AQIDLYAVDG--DEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRT 218
                  I     +   D+ +   + KG GS N + L     A    G  K F++E +  
Sbjct: 123 TGRSSPIIHFEINEELKDKIRITALPKGSGSENMSSLKMLRPADGILGA-KKFVLETIAN 181

Query: 219 LGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLE 278
            G   CPPY +   IGG     +    +         +              +LE+EL  
Sbjct: 182 AGGKGCPPYIVGVGIGGDFESVSHLAKRA--------VMRPVGSRSSDPEGAKLEEELFY 233

Query: 279 EAQKLGLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINRE 331
               LG+G    GGK+ A  + V     H +S PV + V C       A++  +
Sbjct: 234 LVNGLGVGPMGVGGKFTAIGVHVEIGETHISSLPVAVNVQCWRGERATAEVTLD 287


>UniRef50_A4WJ46 Fumarase alpha subunit n=2 Tax=Thermoproteaceae RepID=A4WJ46_PYRAR
          Length = 289

 Score =  296 bits (757), Expect = 2e-78,   Method: Composition-based stats.
 Identities = 68/294 (23%), Positives = 108/294 (36%), Gaps = 15/294 (5%)

Query: 45  EALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAKGVLPT 104
           E +   A++A   AS               H  E  +  +      L+N E++    +  
Sbjct: 4   EVILKAAKEAIVRASIG-PAFDVVSALRTAHGVEEKDAARVQLGAILKNIEMSTTEKIAV 62

Query: 105 CQDTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEVNTGTNL 164
           CQDTG      K G R     G  + L++ V     E  LR +     D  +  N G N 
Sbjct: 63  CQDTGFPNFFIKLGDRFPVRSGIYDILTRAVREVTRELPLRPNTTHPFD--ERKNPGDNT 120

Query: 165 P---AQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRTLGT 221
                  D+   DGD  +F  V KGGG+   +  +     +     L   ++E +   G 
Sbjct: 121 GMYAPWFDVELFDGDYLEFWYVPKGGGTELPSKAFTLPPGVALKE-LPRLVLEAVVDAGP 179

Query: 222 AACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLEEAQ 281
             CPP  +   +G +                                  ++E+ELL+   
Sbjct: 180 MPCPPVIVGIGVGPSVDIAAK-------LAKKAATLRPVGSRHPEPEIAKMEEELLKAIN 232

Query: 282 KLGLGA-QFGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINREGIW 334
           KLGLG    GG+  A D+ +    RH A+  +G+  SC A R   A++  +G +
Sbjct: 233 KLGLGPHGVGGRVTALDVHIEYAYRHPATFSIGIVFSCWATRRAGARVYPDGRY 286


>UniRef50_B8GKW0 Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit
           n=1 Tax=Methanosphaerula palustris E1-9c
           RepID=B8GKW0_METPE
          Length = 282

 Score =  292 bits (747), Expect = 3e-77,   Method: Composition-based stats.
 Identities = 64/297 (21%), Positives = 102/297 (34%), Gaps = 21/297 (7%)

Query: 37  ETILKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEI 96
           +   +     +T     A   A   L    +  +       E            L N   
Sbjct: 5   KAASQALYTKVTEATVSACRKAVIYLPEDVKHVLKKARKKNELDPVALGELENILDNLAC 64

Query: 97  AAKGVLPTCQDTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYK 156
           A K  +P CQDTG  ++       V       + +  GV     E  LR +     D   
Sbjct: 65  AEKYQVPLCQDTGVLVVYMTIPPTVPLTEELYDAVRAGVRRATAEVPLRPNVV---DPIT 121

Query: 157 EVNTGTNLPAQID-LYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEK 215
            VN+G N    +  ++   G       + KG G+ N + +     +     +++ F+V+ 
Sbjct: 122 RVNSGDNTGEGMPAIHVRPGATLSITVLPKGAGAENTSQIAMLLPSQ--KDRIEEFVVKT 179

Query: 216 MRTLGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQE 275
           +   G+  CPP  I   IGGT  E       LA       +           R    EQ 
Sbjct: 180 VLEAGSRPCPPLVIGIGIGGTFDEVA----ALAKEALLQPI----------DRMDLFEQG 225

Query: 276 LLEEAQKLGLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINRE 331
           L +    LG+G    GGK     +++ +   H AS PV + V C A+R     +  +
Sbjct: 226 LCDTLNTLGIGPMGLGGKTSVLAVKMKKGACHTASLPVAVNVQCWANRRATIVVEVD 282


>UniRef50_A0B6L8 Fumarase alpha subunit n=1 Tax=Methanosaeta thermophila PT
           RepID=A0B6L8_METTP
          Length = 271

 Score =  290 bits (742), Expect = 9e-77,   Method: Composition-based stats.
 Identities = 68/294 (23%), Positives = 108/294 (36%), Gaps = 27/294 (9%)

Query: 47  LTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAKGVLPTCQ 106
           +    +     +   L     + +       E SE  +Y     L N  IA     P CQ
Sbjct: 1   MVKATEAVACKSQISLPGWVVR-LIENALRSERSEIARYHLNAILNNIRIAEADARPVCQ 59

Query: 107 DTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEVNTGTNLPA 166
           DTG  +   + G+         E +++GV     +  LR +     D    +NTG N   
Sbjct: 60  DTGLPVFHVEIGEGCSFDFNLWEAIAEGVTIATRKGMLRSNVV---DPLSRLNTGDNTGP 116

Query: 167 QIDLYAVD---GDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRTLGTAA 223
            +    VD   GD  +     KG GS N ++L     A         +++E +    + A
Sbjct: 117 GMPYLIVDHVTGDSLRITAFPKGAGSENMSFLGMLNPADDPF----EYILENLAERVSNA 172

Query: 224 CPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLEEAQKL 283
           CPP  +   IGGT  +      +                      + + E  LL+    L
Sbjct: 173 CPPVFVGIGIGGTFDQAAALAKRAIIG---------------LPGESKEELLLLKRINDL 217

Query: 284 GLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINREGIWIE 336
           G+G    GG   A  +++ R   H AS PV + + C A+R   A++  +G  IE
Sbjct: 218 GIGPMGLGGDTTALGVKIERAFCHTASLPVAVNLQCWANRRATARVTEDGWSIE 271


>UniRef50_B0VIF1 Tartrate dehydratase alpha subunit (TtdA)/Fumarate hydratase class
           I,alpha chain (N-terminal) n=1 Tax=Candidatus
           Cloacamonas acidaminovorans RepID=B0VIF1_9BACT
          Length = 283

 Score =  289 bits (741), Expect = 1e-76,   Method: Composition-based stats.
 Identities = 84/293 (28%), Positives = 123/293 (41%), Gaps = 13/293 (4%)

Query: 38  TILKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIA 97
               V  E +      A    +F   P     +       E SE  K +    L+N E+A
Sbjct: 2   AYRYVSHETIRSELANALKHITFNPDPE-LPALLKSALANETSEISKDILKCMLKNIELA 60

Query: 98  AKGVLPTCQDTGTAIIVGKKGQRVWTGG-GDEETLSKGVYNTYIEDNLRYSQNAALDMYK 156
            K  +P CQDTG+ ++  + G      G    E +++ +  T  E  LR S      + +
Sbjct: 61  PKIEIPLCQDTGSLVVFAEIGNHCIINGPPLPEIINETLIKTSAELYLRPSILK-DPLLQ 119

Query: 157 EVNTGTNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKM 216
             NTG N PA I +  V+GD+ K     KGGG+ N + L   T +      +KNF+VE +
Sbjct: 120 RENTGNNAPAVIHISIVEGDKLKLQIAQKGGGAENMSQLKMFTPSAKVDA-IKNFVVETV 178

Query: 217 RTLGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQEL 276
                 ACPP  I   IGG      L   K         L           +   LEQE+
Sbjct: 179 TLAKGNACPPLIIGIGIGGNFETCALLAKKA--------LFQTLTAKNPIEQYAILEQEI 230

Query: 277 LEEAQKLGLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKI 328
           L+   + G+G Q  GGK  A  + ++  P H AS PV + + C + R+I+  I
Sbjct: 231 LKSVNETGIGVQGLGGKTTALAVHILNAPCHIASLPVAVNLQCHSHRHIEIVI 283


>UniRef50_B5YEU7 Fumarate hydratase n=1 Tax=Dictyoglomus thermophilum H-6-12
           RepID=B5YEU7_DICT6
          Length = 280

 Score =  288 bits (737), Expect = 4e-76,   Method: Composition-based stats.
 Identities = 71/290 (24%), Positives = 118/290 (40%), Gaps = 13/290 (4%)

Query: 40  LKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAK 99
             +  E +     +   + +F L    +  +       E ++N + V    + NS+IA +
Sbjct: 3   RVITQEEIYKELVKLIEEINFSLPKDVESALVE-ARKKEDNKNAQIVLDILIENSKIAKE 61

Query: 100 GVLPTCQDTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEVN 159
             LP CQD G  +   + G+ +   G  E+ ++  V   Y+ D LR S     D  + +N
Sbjct: 62  KKLPLCQDCGMVVAFVEIGRELCISGSIEDVINNAVRTVYVNDFLRKSVVK--DPLRRIN 119

Query: 160 TGTNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRTL 219
           T  N PA I    V+G++ +   + KG GS N + +      +     L + +V+ +R  
Sbjct: 120 TEDNTPAVIHYDIVNGNKLRIYVLIKGFGSENASAVKNLLPTISREE-LMDEIVDHVRLF 178

Query: 220 GTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLEE 279
           G  ACPP  +   IGGT  +  + + K         L     EH Q       E +LLE 
Sbjct: 179 GPNACPPLIVGVGIGGTLEKAAILSKKA--------LLRPIGEHNQDPFWASFEDDLLER 230

Query: 280 AQK-LGLGAQFGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKI 328
                      GGK  A  + V   P H A   + + + C A R+   ++
Sbjct: 231 INALGIGPGGLGGKTTALAVNVEIYPVHIAGFTLAISLQCCAVRHGWIEL 280


>UniRef50_C9KL20 L(+)-tartrate dehydratase subunit alpha n=1 Tax=Mitsuokella
           multacida DSM 20544 RepID=C9KL20_9FIRM
          Length = 299

 Score =  283 bits (725), Expect = 1e-74,   Method: Composition-based stats.
 Identities = 63/301 (20%), Positives = 104/301 (34%), Gaps = 23/301 (7%)

Query: 36  GETILKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSE 95
            E +  +  + +                P   +     L   E     K +     RN E
Sbjct: 4   EEAVRHM-TDIMAKFVAFTGKRL-----PDDVRAKIEELAKQEEEPLAKAIYQTMERNQE 57

Query: 96  IAAKGVLPTCQDTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMY 155
           +A K   P+CQDTG      K G          + L + V     +  LR++     + +
Sbjct: 58  LALKLNRPSCQDTGALQFFIKCGTAFPYMAELPDLLREAVVQATKDAPLRHNAV---ETF 114

Query: 156 KEVNTGTNLP---AQIDLYAVDG-DEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNF 211
            E NTG N+      I      G D+ +      GGG +   +           G +  F
Sbjct: 115 DEYNTGKNVAKGIPSIFWDIAPGRDDCEIYTYMAGGGCSLPGHAKVLMPGEGYEG-VTKF 173

Query: 212 LVEKMRTLGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQ 271
           +++ M + G  ACPP  +   IG +     L++ K         L      H    +  +
Sbjct: 174 VLDVMTSYGLNACPPLLVGVGIGTSVEVAALQSKKA--------LMRRIGSHNPNPKAAK 225

Query: 272 LEQELLEEAQKLGLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINR 330
           +EQ L +    +GLG Q   GK     + +    RH +   V + V C + R      ++
Sbjct: 226 MEQLLEDGINAIGLGPQGLRGKNSVLGVNIENSARHPSVIGVAVNVGCWSHRRGHIVFDK 285

Query: 331 E 331
           E
Sbjct: 286 E 286


>UniRef50_A8S1R3 Putative uncharacterized protein n=1 Tax=Clostridium bolteae ATCC
           BAA-613 RepID=A8S1R3_9CLOT
          Length = 299

 Score =  282 bits (722), Expect = 2e-74,   Method: Composition-based stats.
 Identities = 64/298 (21%), Positives = 108/298 (36%), Gaps = 17/298 (5%)

Query: 39  ILKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAA 98
           +   + +       + F   S    P           + E S+  K +   +  N ++A 
Sbjct: 1   MTHEDAKQRFTDIMEKFIGMSSKRLPDDVYAKLKECGEKEDSDIQKVIYNAYFENLDMAG 60

Query: 99  KGVLPTCQDTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEV 158
           K   P CQDTG      K G      G   + L +  +N      LR +     + ++E 
Sbjct: 61  KLSRPCCQDTGLLHFYIKMGTGFAYQGMVADCLREATHNATYSAPLRQNTV---NYFEER 117

Query: 159 NTGTNLP---AQIDLYAVDG-DEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVE 214
           NT  N       I+   V   D+ + +    GGG            +      +  ++ +
Sbjct: 118 NTNDNTGERMPWINWDIVPDNDDLEIITYFAGGGCCLPGRSQVFKPSDGY-AAIIRYVFD 176

Query: 215 KMRTLGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQ 274
            +  LG  ACPP  +   +G  +    L + K                     +  QLEQ
Sbjct: 177 AVSDLGINACPPLIVGVGLGHNAENAALLSKKA--------YLRPLGTSHPHPKGAQLEQ 228

Query: 275 ELLEEAQKLGLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINRE 331
           +LLE   KLG+GAQ   G   A ++ +    RH A+  +G+ V+C A R    + + +
Sbjct: 229 DLLEGLNKLGIGAQGLRGNCAAMEVHIESSARHTATIAIGVNVACYAHRRGVIRFHND 286


>UniRef50_Q0TD45 L(+)-tartrate dehydratase subunit alpha n=126 Tax=Bacteria
           RepID=TTDA_ECOL5
          Length = 303

 Score =  280 bits (716), Expect = 1e-73,   Method: Composition-based stats.
 Identities = 65/315 (20%), Positives = 110/315 (34%), Gaps = 23/315 (7%)

Query: 31  VADFDGETILKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQF 90
           +++ + +  +      LT +    F        P         L D E S   K +    
Sbjct: 2   MSESNKQQAVN----KLTEIVAN-FTAMISTRMPDDVVDKLKQLKDAETSSMGKIIYHTM 56

Query: 91  LRNSEIAAKGVLPTCQDTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNA 150
             N + A     P CQDTG  +   K G R    G  +  L + V    ++  LR++   
Sbjct: 57  FDNMQKAIDLNRPACQDTGEIMFFVKVGSRFPLLGELQSILKQAVEEATVKAPLRHNAV- 115

Query: 151 ALDMYKEVNTGTNLP---AQIDLYAVDG-DEYKFLCVAKGGGSANKTYLYQETKALLTPG 206
             +++ EVNTG N       +    +   D+ +      GGG            +    G
Sbjct: 116 --EIFDEVNTGKNTGSGVPWVTWDIIPDNDDAEIEVYMAGGGCTLPGRSKVLMPSEGYEG 173

Query: 207 KLKNFLVEKMRTLGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQA 266
            +K F+ E + TL   ACPP  +   I  +     + + K         +          
Sbjct: 174 VVK-FVFENISTLAVNACPPVLVGVGIATSVETAAVLSRKA--------ILRPIGSRHPN 224

Query: 267 FRDVQLEQELLEEAQKLGLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIK 325
            +  +LE  L E   +LG+G Q   G      + +    RH ++  V +   C A R   
Sbjct: 225 PKAAELELRLEEGLNRLGIGPQGLTGNSSVMGVHIESAARHPSTIGVAVSTGCWAHRRGT 284

Query: 326 AKINREGIWIEKLEH 340
             ++ + +  E L H
Sbjct: 285 LLVHAD-LTFENLSH 298


>UniRef50_A9BJT0 Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit
           n=9 Tax=Thermotogaceae RepID=A9BJT0_PETMO
          Length = 309

 Score =  269 bits (689), Expect = 1e-70,   Method: Composition-based stats.
 Identities = 69/297 (23%), Positives = 119/297 (40%), Gaps = 19/297 (6%)

Query: 37  ETILKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYV---ALQFLRN 93
           +T++  + E   +  ++ F   S      H  Q    ++    +  D Y    +     N
Sbjct: 26  KTVIHCKKEIGMIYKREIFEKLS-----NHIVQANETINPEVKAYIDGYSGPFSQALKEN 80

Query: 94  SEIAAKGVLPTCQDTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALD 153
            +IA    LP CQDTG        G  V        TL++ V   Y E+  R+S      
Sbjct: 81  YKIAEAEKLPLCQDTGIVEFFVFLGNEVVLEEPIFTTLNEVVEKVYAENPFRFSVVN-DP 139

Query: 154 MYKEVNTGTNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLV 213
           +++  NT  N P  + ++ + G   +   + KGGGS N + L+    ++    +LK+ ++
Sbjct: 140 LFERKNTKNNTPPVVHIFQISGKSLEIKFLVKGGGSENLSALFMLKPSI-RAQELKDVII 198

Query: 214 EKMRTLGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLE 273
             ++  G   CPP H+   IGGTS +  + +    +  +         E  Q       E
Sbjct: 199 GHVKENGAKGCPPLHVGIGIGGTSDKAMILSKLALTKSF--------KERNQNPTYADFE 250

Query: 274 QELLEEAQKLGLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKIN 329
           +ELL++   L +G Q          + +   P H A+ PVG+ + C   R    K  
Sbjct: 251 EELLKDLNTLNIGFQGLKEGVSVFSVHIEYAPTHIATLPVGVSLDCYLCRKGVVKFE 307


>UniRef50_A1WMD3 Fumarase alpha subunit n=1 Tax=Verminephrobacter eiseniae EF01-2
           RepID=A1WMD3_VEREI
          Length = 290

 Score =  268 bits (686), Expect = 3e-70,   Method: Composition-based stats.
 Identities = 55/296 (18%), Positives = 103/296 (34%), Gaps = 14/296 (4%)

Query: 40  LKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAK 99
           + ++   L  +  Q +  +   + P   +   A     E     K +    L++++ A +
Sbjct: 1   MAIDSATLQRVTAQLYERSLKKI-PDDTRAALARAETAETDVTGKRMLKIMLQSADAAQQ 59

Query: 100 GVLPTCQDTGTAIIVGKKGQRVWTGGGDEETLSKG-VYNTYIEDNLRYSQNAALDMYKEV 158
                C D G  +   K G RV   G     +++G        D            ++  
Sbjct: 60  DNELVCSDVGIPVYSIKIGTRVQFEGPVRAAITRGFAELVQRSDPPILKMVTNPLTHERS 119

Query: 159 NTGTNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRT 218
           + G ++P        D D  + +C  K  G+     +       L   +++ F+++ +  
Sbjct: 120 HAGKDMPLLSFDVIDDADYVEIVCAPKAMGTGRWEAIDVFVYPTL--EQIERFILDTVLR 177

Query: 219 LGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLE 278
            G+  C P  I   IGGT         +LA                       +EQ LL+
Sbjct: 178 AGSQPCLPIVIGVGIGGTFDHAA----RLAKESVLRPF----GRTNPEPILAAMEQRLLD 229

Query: 279 EAQKLGLGAQF-GGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINREGI 333
               +G G    GG   A  + +     HG   PV + ++C  +R   A+I+ +G 
Sbjct: 230 AVNAMGFGPMGTGGDASAMAVHIDYAASHG-FVPVAVCLNCWINRRTAARIHNDGR 284


>UniRef50_B0EPH7 Serine acetyltransferase, putative n=10 Tax=cellular organisms
           RepID=B0EPH7_ENTDI
          Length = 523

 Score =  267 bits (684), Expect = 5e-70,   Method: Composition-based stats.
 Identities = 142/249 (57%), Positives = 189/249 (75%), Gaps = 11/249 (4%)

Query: 298 IRVIRLPRHGASCPV------GMGVSCSADRNIKAKINREGIWIEKLEHNPGQYIPQELR 351
           + +   P H     V      G+ +SCSADRNIK KI ++GI++E+LEHNP QY+    R
Sbjct: 266 VYISEHPTH----FVKPCANKGVKISCSADRNIKGKITKDGIFVEELEHNPEQYLCGLTR 321

Query: 352 QAGEGEAVKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELP 411
              + E  +++L+ PM EIL QL+  PV + + L+GTIIV RDIAHA++ +++    ++P
Sbjct: 322 DISK-EPTRINLDVPMPEILKQLTVLPVESPVLLSGTIIVARDIAHARINDILKETGDVP 380

Query: 412 QYIKDHPIYYAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVT 471
           QYIKDHPIYYAGPAK P GYPSGS GPTT+ RMD YVD  Q+HGGS++M+AKGNRS+ +T
Sbjct: 381 QYIKDHPIYYAGPAKQPKGYPSGSFGPTTSARMDPYVDDFQAHGGSLVMIAKGNRSEMLT 440

Query: 472 DACHKHGGFYLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKG 531
           +AC KHGGFYLG+IGG AA+LA+++IK +EC+A+ +LGMEA+WKI+VED  AF+LVDDKG
Sbjct: 441 NACKKHGGFYLGAIGGAAALLAEKNIKSVECIAFEDLGMEAVWKIKVEDLLAFVLVDDKG 500

Query: 532 NDFFQQIVN 540
           NDFF+QI  
Sbjct: 501 NDFFKQIKP 509


>UniRef50_C7IGU6 Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit
           n=2 Tax=Clostridium RepID=C7IGU6_9CLOT
          Length = 291

 Score =  264 bits (675), Expect = 6e-69,   Method: Composition-based stats.
 Identities = 63/296 (21%), Positives = 102/296 (34%), Gaps = 19/296 (6%)

Query: 48  TLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAKGVLPTCQD 107
             + +      S+ +     + +     + E  E+ K +    + N  IA +     CQ 
Sbjct: 4   RQVLRDLIFKISYEVS-DDCRCLLNKAVEIETDESSKMILETIIENVSIARECKQALCQS 62

Query: 108 TGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEVNTGTNLP-- 165
            G        G   +     E+ L + V +      LR S     D    VN+G N    
Sbjct: 63  PGYLTTYVTFGDDFFIS-DLEQILKEAVIDATKAGYLRPSMV---DPLTRVNSGDNSGRG 118

Query: 166 -AQIDLYAVDG-DEYKFLCVAKGGGSA--NKTYLYQETKALLTPGKLKNFLVEKMRTLGT 221
              ++     G D  + +   KG G    NK  ++   +       +K F++E +   G 
Sbjct: 119 VPNMEYEYKKGIDYIEIIPSIKGCGIELYNKVKVFTIAEIGDNFEGIKKFVLECVVEAGG 178

Query: 222 AACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLEEAQ 281
            AC P  I   IGG        + +  S   +        +  +  R  QLE ELLE   
Sbjct: 179 TACLPSAIGIGIGGQLDVAAKLSRRAMSLRGW-------MQRSEDKRLAQLEDELLEAIN 231

Query: 282 KLGLG-AQFGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINREGIWIE 336
            L +G    GGK     + +     H   CPV +   C   R    +I ++G   E
Sbjct: 232 SLNIGSGGTGGKVTTLGVNIETAATHTTLCPVAINFHCWVARRAGIRIYKDGRVEE 287


>UniRef50_A7HKF1 Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit
           n=1 Tax=Fervidobacterium nodosum Rt17-B1
           RepID=A7HKF1_FERNB
          Length = 277

 Score =  259 bits (662), Expect = 2e-67,   Method: Composition-based stats.
 Identities = 70/294 (23%), Positives = 124/294 (42%), Gaps = 18/294 (6%)

Query: 39  ILKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAA 98
           ++K++ + +     +   + +  ++P                   K      + N EIA+
Sbjct: 1   MVKIKSDVVFEKISEVLIEINTKIKPE-----IKEFFKDYEGPFKKE----IIENFEIAS 51

Query: 99  KGVLPTCQDTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEV 158
           K  LP CQDTG       KG  V      E  L + V + Y     R S  +   ++  V
Sbjct: 52  KEYLPLCQDTGMVEFFVFKGFNVLLDKPIEYILDEAVKDVYERFGFRKSVVS-DPLFSRV 110

Query: 159 NTGTNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRT 218
           NT TN P  + L+ ++ ++ +   +AKGGGS N + LY    +      +   + E ++ 
Sbjct: 111 NTRTNTPCVVHLFEIEENKLEIWTIAKGGGSENLSALYMFNPSESYEA-ISQKIFEHIKQ 169

Query: 219 LGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLE 278
            G  ACPP  +   +GGTS +  + + KLA   Y   +  +        R  + E++L+E
Sbjct: 170 NGPNACPPIKVGVGVGGTSDKAVMLS-KLALFDYDASVYLK-----NVIRYQKAEEKLME 223

Query: 279 EAQKLGLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINRE 331
              ++  G Q  G     +++++   P H A+ PV + V C   R+ +     E
Sbjct: 224 RLNEIKFGVQGLGYGKGIYNVKMYGFPTHIATLPVAISVDCYLLRSGRVVFENE 277


>UniRef50_C8WG72 Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit
           n=2 Tax=Coriobacteriaceae RepID=C8WG72_EGGLE
          Length = 354

 Score =  259 bits (661), Expect = 2e-67,   Method: Composition-based stats.
 Identities = 75/290 (25%), Positives = 113/290 (38%), Gaps = 13/290 (4%)

Query: 41  KVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAKG 100
            +    +      A    + +L     +   A+  + E +   + V  Q + N+ IAA+ 
Sbjct: 4   IITKSQVADAVYAAIPKLACVLPAD-IEAGLAVARELEGNPRGRAVLDQLIENAAIAAED 62

Query: 101 VLPTCQDTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEVNT 160
            +P CQDTGT  +  + G  V   G     +   V   Y E  LR S      +    NT
Sbjct: 63  RVPICQDTGTVWVSLEIGPDVAVRGDVFADVDDAVARAYDEARLRKSVVR-DAVLDRANT 121

Query: 161 GTNLPAQIDLYAVDGDE-YKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRTL 219
           G N PA  D++ VD     +   + KGGGS N + +          G + + LV  +R  
Sbjct: 122 GDNTPAFCDVHPVDEPGAARLHVMLKGGGSDNASRVVMLVPGAGKQG-IVDELVRCVREK 180

Query: 220 GTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLEE 279
           G  ACPP  +   IG T  +      +         L    +E     R   LE+ELL  
Sbjct: 181 GANACPPLVVGVGIGSTFDKVAGLAKRA--------LMRPVDEPAADDRLRALEEELLAA 232

Query: 280 AQKL-GLGAQFGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKI 328
                      GG+  A  +RV   P H A+ P+ + + CSA R I   +
Sbjct: 233 VNATGIGPGGLGGRTTALAVRVATAPCHIAALPLAINMGCSAMRRITVPL 282


>UniRef50_Q8U062 Possible fumarate hydratase (Fumarase) alpha subunit n=4
           Tax=Thermococcaceae RepID=Q8U062_PYRFU
          Length = 272

 Score =  255 bits (651), Expect = 3e-66,   Method: Composition-based stats.
 Identities = 69/286 (24%), Positives = 114/286 (39%), Gaps = 21/286 (7%)

Query: 48  TLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAKGVLPTCQD 107
                +A   A   L P          ++ E  E  KY     LR  + + K  +P CQD
Sbjct: 1   MEDIVEALKLAVTNL-PEDVALALKNAYEREDYEIAKYNLEIMLRAVKTSKKEKVPLCQD 59

Query: 108 TGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEVNTGTNLPAQ 167
           TGT I   +     W      ET+++ V     E  LR +   A+ +      G N+P  
Sbjct: 60  TGTPIFFVET-DGTWNVKEIYETIAEAVKRATDEIPLRPN---AICLLSGKVVG-NVP-- 112

Query: 168 IDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRTLGTAACPPY 227
            +++   G   +   + KGGGS N + L+  T      G +K  +++ +R+ G   CPP 
Sbjct: 113 -EIHIEPGKRNRISILIKGGGSENCSALFPLTPGDWFEG-VKKKIIDHIRSCGGKPCPPI 170

Query: 228 HIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLEEAQKLGLGA 287
            +   I    A    + + LA    + ++     + G    ++  E   L+      +G 
Sbjct: 171 IVGIGI----ASPAERAITLAKKSLFRKIGERHEKLGWLEEEILEEINFLD------IGP 220

Query: 288 Q-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINREG 332
              GGK  A D+++    RH AS  VG+ + C A R    +   +G
Sbjct: 221 MGLGGKTTALDVKIEVGERHPASFIVGIAIQCWAHRRAFIEEKEDG 266


>UniRef50_Q3IXH2 Fumarase alpha subunit n=14 Tax=Proteobacteria RepID=Q3IXH2_RHOS4
          Length = 320

 Score =  249 bits (636), Expect = 2e-64,   Method: Composition-based stats.
 Identities = 63/323 (19%), Positives = 104/323 (32%), Gaps = 24/323 (7%)

Query: 42  VEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAKGV 101
           +  + +   A++    A+  + P             E  +   +V    L N E A +  
Sbjct: 2   ISLDLIQRTAERLMEKAAIEI-PEDYLDGLKATAAVEDGDLSSFVLQAMLENYEAAKEDR 60

Query: 102 LPTCQDTGTAIIVGKKGQRVWTGGG---DEETLSKGVYNTYIEDNLRYSQNAALDMYKEV 158
              C DTG      K G      GG    E  L +       +  LR ++   L      
Sbjct: 61  RAMCGDTGCPRWYVKMGNEAHIEGGPIALEAALRRATARATHDIPLRPNRVHPLWRTDHD 120

Query: 159 -NTGTNLPAQIDLYAVDGDEYKFLCVAKGG--GSANKTYLYQETKALLTPGKLKNFLVEK 215
            N G   P     +   GD    + V KGG  G+           +    G ++ F ++ 
Sbjct: 121 NNVGIGAPEIEYGFEPGGDWIDLITVHKGGLFGTDY----RMLFPSDGIQG-IRRFFLDS 175

Query: 216 MRTLG--TAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLE 273
           +   G    AC P  I   +GG+     +   + A                   R   LE
Sbjct: 176 LVAFGKRGLACQPAIIGIGLGGSKDACMVLGKRAA-------CLRTVGSRNSDPRIAALE 228

Query: 274 QELLEEAQKLGLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINREG 332
            EL E    +G+GA  F GK    D  +     H     + +   C + R   A++  +G
Sbjct: 229 GELKELGNSIGMGAMGFVGKSMVVDCNIEVGYCHTGGMQMSVHAFCLSSRRAVARLWGDG 288

Query: 333 IWIEKLEHNPGQYIPQELRQAGE 355
               +   +P  +   + R+  E
Sbjct: 289 R--VEYRTDPDWFTDYQRRETVE 309


>UniRef50_Q2RG70 Hydro-lyases, Fe-S type, tartrate/fumarate subfamily, beta region
           n=69 Tax=Bacteria RepID=Q2RG70_MOOTA
          Length = 219

 Score =  248 bits (633), Expect = 5e-64,   Method: Composition-based stats.
 Identities = 70/197 (35%), Positives = 103/197 (52%), Gaps = 4/197 (2%)

Query: 347 PQELRQAGEGEAVKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDA 406
           P    +      ++  L+ P+   +  +       R+ ++G I   RD AH +L EL+D 
Sbjct: 22  PAGDNRRTGDSPIR-HLHTPLS--VDDVESLRAGDRVLISGVIYAARDSAHKRLVELLDR 78

Query: 407 GKELPQYIKDHPIYYAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNR 466
           G+ELP  +K   IYY GP     G  +G+ GPTT+GRMD Y   L +  G   M+ KG R
Sbjct: 79  GEELPVDLKGQVIYYVGPTPARPGRVTGAAGPTTSGRMDPYTPRLIAATGLKGMIGKGFR 138

Query: 467 SQQVTDACHKHGGFYLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFIL 526
           S +V  A   H   Y  ++GG  A++A + IK  E VAYPELG EA+  +EVED P  ++
Sbjct: 139 SPEVKKALVDHKAVYFAAVGGAGALIA-RCIKKAEIVAYPELGPEALRALEVEDLPVTVI 197

Query: 527 VDDKGNDFFQQIVNKQC 543
            D  G D + + + +  
Sbjct: 198 NDCYGGDLYTEALARYS 214


>UniRef50_A6TTM2 Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit
           n=22 Tax=cellular organisms RepID=A6TTM2_ALKMQ
          Length = 185

 Score =  246 bits (629), Expect = 1e-63,   Method: Composition-based stats.
 Identities = 67/189 (35%), Positives = 102/189 (53%), Gaps = 4/189 (2%)

Query: 359 VKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHP 418
           +   +  P+     ++        + LTG I   RD AH +L +L++AG++LP  ++D  
Sbjct: 1   MSKKITMPLT--AEKVKSLKAGDSVLLTGMIYTARDAAHKRLVDLLEAGEDLPIELQDQV 58

Query: 419 IYYAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHG 478
           IYY GP     G P GS GPTT+ RMDSY   L    G   M+ KG R + V  A  + G
Sbjct: 59  IYYVGPTPAKEGQPIGSAGPTTSYRMDSYTPALLEQ-GLKGMIGKGLRGESVITAIKQQG 117

Query: 479 GFYLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQI 538
             Y  +IGG +A++A + +K  E +AY +LG EAI K+ VED P  +++D KGN++++  
Sbjct: 118 AVYFAAIGGASALMA-KCVKSAEIIAYEDLGAEAIRKLYVEDLPLIVVIDAKGNNYYEIG 176

Query: 539 VNKQCANCT 547
             +      
Sbjct: 177 QEEYLKTLR 185


>UniRef50_C3PJK7 Tartrate dehydratase n=18 Tax=Bacteria RepID=C3PJK7_CORA7
          Length = 344

 Score =  244 bits (622), Expect = 1e-62,   Method: Composition-based stats.
 Identities = 60/298 (20%), Positives = 97/298 (32%), Gaps = 20/298 (6%)

Query: 41  KVEPEA--LTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAA 98
           +  PE   L     + F D      P    +    L + E     K +     RN ++A 
Sbjct: 47  QFSPEVQLLIDRVAK-FTDLVSKRLPDDVTERLRQLAEEEDQPMAKMIYKTMQRNQKLAL 105

Query: 99  KGVLPTCQDTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEV 158
               P+CQDTG   I  + G         E  + + +        LR +     + + E 
Sbjct: 106 DLDRPSCQDTGQIQIFARVGTEFPYLSELEPAMKEAIGIASETAPLRRNSV---ETFNEY 162

Query: 159 NTGTNLP---AQIDLYAVDG-DEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVE 214
           N GTN+      +    + G DE +      GGG +                 +K F+++
Sbjct: 163 NPGTNIGTKSPWLYTELISGSDELELDVYLAGGGCSLPGQGKTLMPGEGYEAAMK-FILD 221

Query: 215 KMRTLGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQ 274
            M + G  ACPP  I   IG +       +           L      H Q     +LE+
Sbjct: 222 VMTSYGVNACPPMLIGVGIGTSIDTAGFMSKLA--------LMRPVQSHNQNEVVAELEK 273

Query: 275 ELLEEAQK-LGLGAQFGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINRE 331
            L              GGK     + +    RH +   V +   C + R     ++R+
Sbjct: 274 NLETAINDLGLGPQGLGGKRSVMGVNIENSARHPSVLSVAVNTGCWSHRRGTIHLDRD 331


>UniRef50_C1SNL0 Hydro-lyase, Fe-S type, tartrate/fumarate subfamily n=1
           Tax=Denitrovibrio acetiphilus DSM 12809
           RepID=C1SNL0_9BACT
          Length = 288

 Score =  242 bits (619), Expect = 2e-62,   Method: Composition-based stats.
 Identities = 63/297 (21%), Positives = 110/297 (37%), Gaps = 20/297 (6%)

Query: 46  ALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAKGVLPTC 105
            L     +    A+  L P  +  +       +     K V      N  +A +   P C
Sbjct: 2   ELKDAMLELIRRATTDLSPDVENAIQQAYDREDEGTPAKSVFGTIRENIALAREASTPIC 61

Query: 106 QDTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEVNTGTNLP 165
           QDTG+ II          G  + +      +       L+Y +  A+D     N+G N+ 
Sbjct: 62  QDTGSVIIYI----DFPVGEPETKYKEAAEWAAAEATKLQYLRPNAVDPITGKNSGNNVG 117

Query: 166 ---AQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGK----LKNFLVEKMRT 218
                +  +  D DE +   + KGGGS N    Y+   ++L  G+    +K  +++ ++ 
Sbjct: 118 TNAPYLHFHQWDKDETRVRLMLKGGGSENVGAQYKLPDSVLHAGRDLKGVKKVVIDAVQK 177

Query: 219 LGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLE 278
                C P  +            + +  L+   ++ +L     E        +LE+EL E
Sbjct: 178 AQGQGCAPGVVG----IGIGGDRVTSYALSKEQFFRKL----GEKSTNPDLAKLEEELYE 229

Query: 279 EAQKLGLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINREGIW 334
           +  KLG+G   FGGK     +      RH A+  V +  +C A R  +  I    + 
Sbjct: 230 DLNKLGIGPMGFGGKTTCLGVFAGVQHRHPATFYVAISYTCWAYRRKQMTIKGSEVT 286


>UniRef50_B8I5L5 Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit
           n=8 Tax=Bacteria RepID=B8I5L5_CLOCE
          Length = 185

 Score =  237 bits (606), Expect = 6e-61,   Method: Composition-based stats.
 Identities = 68/186 (36%), Positives = 102/186 (54%), Gaps = 4/186 (2%)

Query: 359 VKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHP 418
           +   L  P     A+L        +SL+GTI   RD AH K+ EL+   +ELP  + +  
Sbjct: 1   MHHILTAPFDRDKARL--LKAGDTVSLSGTIYTARDAAHKKMIELLQENRELPFDMSNQT 58

Query: 419 IYYAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHG 478
           IYY GP  +  G   GS GPT++ RMD+Y   L    G   M+ KG R Q V +A  ++G
Sbjct: 59  IYYVGPCPSREGEIIGSAGPTSSYRMDAYAPTLIRL-GETAMIGKGLRDQNVINAMKEYG 117

Query: 479 GFYLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQI 538
             YLG+IGG  A++A+  IK  E +A+PELG EA+  +E+ +FP  +++D  GN+ ++  
Sbjct: 118 AVYLGAIGGAGALMAE-CIKRQEIIAFPELGAEAVRHLEIINFPLIVVIDSHGNNLYESG 176

Query: 539 VNKQCA 544
             +   
Sbjct: 177 RKQYRK 182


>UniRef50_A4XHH2 Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit
           n=2 Tax=Clostridia RepID=A4XHH2_CALS8
          Length = 204

 Score =  234 bits (598), Expect = 5e-60,   Method: Composition-based stats.
 Identities = 65/190 (34%), Positives = 100/190 (52%), Gaps = 3/190 (1%)

Query: 357 EAVKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKD 416
           E     L  P+     ++  + V   + ++G + V RD AH +L ++   G+++P   K+
Sbjct: 17  EQKLKRLYIPVTNE-EEIKSFKVGQEVLVSGRLFVARDAAHKRLIDMFKRGEDIPIDFKN 75

Query: 417 HPIYYAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHK 476
             IYY GP     G   G  GPTTAGRMD +  ++    G  +++ KG RS QV +A   
Sbjct: 76  GAIYYMGPCPEKPGEVIGPCGPTTAGRMDIFTPIVLKL-GVKVLIGKGKRSPQVKEAIKS 134

Query: 477 HGGFYLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQ 536
           +G  YL + GG AA+L Q  +K  + + + +LG EAI +IEVED P  + VD +G D ++
Sbjct: 135 YGAIYLATFGG-AAILIQSCVKSQKILMFEDLGPEAIREIEVEDLPCVVAVDSQGEDIYE 193

Query: 537 QIVNKQCANC 546
               K   N 
Sbjct: 194 IGPRKYARNL 203


>UniRef50_Q58034 Putative fumarate hydratase subunit beta n=13 Tax=Euryarchaeota
           RepID=FUMB_METJA
          Length = 195

 Score =  234 bits (596), Expect = 8e-60,   Method: Composition-based stats.
 Identities = 50/183 (27%), Positives = 87/183 (47%), Gaps = 4/183 (2%)

Query: 370 ILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHPIYYAGPAKTP- 428
               + +  V   + L G I   RD AH K+ E++ + ++LP  + +  IY+AGP     
Sbjct: 9   TKKDVKKLKVGDIVYLNGKIYTARDEAHLKIIEMLKSNEKLPFDLNESIIYHAGPIMKKV 68

Query: 429 -AGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHGGFYLGSIGG 487
              +   S+GPTT+ RM+   +          ++ KG   +++      +G  YL + GG
Sbjct: 69  NDSWVCVSIGPTTSARMNDVEEEFIKLTNISAIVGKGGMKKELLKTFEDYGVVYLAAPGG 128

Query: 488 PAAVLAQQSIKHLECVAYPELGM-EAIWKIEVEDF-PAFILVDDKGNDFFQQIVNKQCAN 545
            AA+LA    +        ELGM EA+W++EV +F P  + +D  GN  ++++  K    
Sbjct: 129 CAALLANSVKRVDNVYFLDELGMPEAVWELEVNNFGPLIVAMDSHGNSIYEEVNKKVYEK 188

Query: 546 CTK 548
             +
Sbjct: 189 LNE 191


>UniRef50_D1SM64 Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit
           n=1 Tax=Methanocaldococcus sp. FS406-22
           RepID=D1SM64_9EURY
          Length = 218

 Score =  234 bits (596), Expect = 8e-60,   Method: Composition-based stats.
 Identities = 57/201 (28%), Positives = 94/201 (46%), Gaps = 7/201 (3%)

Query: 352 QAGEGEAVKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELP 411
           +  EGE ++   N   K     + +  V   + L G I   RD AH K+ E+I   ++LP
Sbjct: 17  KTIEGENLEYTFN---KLTKRDVKKLRVGDIVYLNGKIYTARDEAHLKIIEMIKNKEKLP 73

Query: 412 QYIKDHPIYYAGPAKTP--AGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQ 469
             + +  IY+AGP        +   S+GPTT+ RM+   +          ++ KG   ++
Sbjct: 74  FDLNEAIIYHAGPIMKKVNDNWTCISIGPTTSARMNDVEEEFIKLTNISAIVGKGGMKKE 133

Query: 470 VTDACHKHGGFYLGSIGGPAAVLAQQSIKHLECVAYPELGM-EAIWKIEVEDF-PAFILV 527
           +       G  YL + GG AA+LA    K        ELGM EA+W++EV++F P  + +
Sbjct: 134 LLKTFEDFGVVYLAAPGGCAALLANSVKKVNNVYFLEELGMPEAVWELEVDNFGPLIVAM 193

Query: 528 DDKGNDFFQQIVNKQCANCTK 548
           D  GN  ++++  K      +
Sbjct: 194 DCFGNSIYEEVNKKVYEKLNE 214


>UniRef50_C4GCC8 Putative uncharacterized protein n=1 Tax=Shuttleworthia satelles
           DSM 14600 RepID=C4GCC8_9FIRM
          Length = 197

 Score =  230 bits (588), Expect = 8e-59,   Method: Composition-based stats.
 Identities = 67/186 (36%), Positives = 100/186 (53%), Gaps = 4/186 (2%)

Query: 360 KVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHPI 419
           ++ +  P+++    + +      + L G + V RD AH +L +LI AGK+LP  ++   I
Sbjct: 3   EIKIRLPLRD--EVIEKLRAGDYVYLKGDLYVARDAAHKRLMDLIKAGKKLPISLEGETI 60

Query: 420 YYAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHGG 479
           YY GP+    G   GS GPTTA RMD Y   L    G   M+ KG RS +V DA  +   
Sbjct: 61  YYMGPSPAREGQVIGSAGPTTASRMDKYTPTLLDL-GLKGMVGKGKRSSEVLDAIVRDHA 119

Query: 480 FYLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQIV 539
            Y  ++GG  A+L+ + I+  E V Y +LG EAI +I VE  P  +L+D KGN+ ++   
Sbjct: 120 IYFAAVGGAGALLS-KCIRKSEIVCYEDLGAEAIRRITVEALPLVVLIDCKGNNLYEAAS 178

Query: 540 NKQCAN 545
            +   N
Sbjct: 179 REYADN 184


>UniRef50_UPI0001C35B8B hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit
           n=1 Tax=Clostridium hathewayi DSM 13479
           RepID=UPI0001C35B8B
          Length = 288

 Score =  226 bits (576), Expect = 2e-57,   Method: Composition-based stats.
 Identities = 47/293 (16%), Positives = 91/293 (31%), Gaps = 26/293 (8%)

Query: 46  ALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAKGVLPTC 105
            +T    Q   DAS   R   Q          E   + K+    F++N+ +A K     C
Sbjct: 6   KVTEDVAQTVVDASSHWR-DDQVACWKQACAEEEIPHAKWAMENFIKNAAVADKKHCALC 64

Query: 106 QDTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEVNTGTNL- 164
            DTGT     + G       G    +  G+     +   R       D  + ++    L 
Sbjct: 65  DDTGTPHPFLEIGDEAVLPAGFLAAMEDGIRKGLNDLPARPMGVRG-DELERISQCKGLY 123

Query: 165 -------PAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMR 217
                  PA   +  + G   +   +  GGG   ++              ++  +   + 
Sbjct: 124 DEPGMLKPAPTQIRRMAGSRIRLTILMLGGGPEIRSRTQALFHMHSLDHVVEEMIEWAVP 183

Query: 218 TLGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELL 277
            +    C P  ++F +G T+ E +  +++      YD                ++E+ + 
Sbjct: 184 QVAALGCQPCTLSFGLGRTAVEASSLSLEAMKDGCYDV-------------QSEMEKRIT 230

Query: 278 EEAQKLGLGA-QFGGKYFAHDIRVIRLPRHGASC-PVGMGVSCSAD-RNIKAK 327
           +     G+G    GG        +       +    V M  +C  + R    +
Sbjct: 231 DAVNGKGIGPIGLGGASSVLATFIKIGDMRASGFRVVSMRPNCCMEIRKASCE 283


>UniRef50_Q469V5 Fumarase beta subunit n=10 Tax=Archaea RepID=Q469V5_METBF
          Length = 191

 Score =  225 bits (574), Expect = 3e-57,   Method: Composition-based stats.
 Identities = 62/194 (31%), Positives = 97/194 (50%), Gaps = 9/194 (4%)

Query: 359 VKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHP 418
           ++  L  P+K+    + +      + ++G I+  RD AHA++ E+ +  +ELP  ++   
Sbjct: 1   MEYHLKTPLKK--EDIEKLNAGDIVYISGEILTARDEAHARILEMGEKKEELPFSLEGAV 58

Query: 419 IYYAGPAKTP--AGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHK 476
           IY+ GP       G+   S GPTT+GRM      L        ++ KG     V DA   
Sbjct: 59  IYHCGPLMQKTENGWKVVSAGPTTSGRMSKMTPPLLKAHDVRAIIGKGGMKD-VADALK- 116

Query: 477 HGGFYLGSIGGPAAVLAQQSIKHLECVAYPELGM-EAIWKIEVEDF-PAFILVDDKGNDF 534
           +G  YL   GG AA LA + IK ++ V + +LGM EA+W + VE+F P  + +D KG D 
Sbjct: 117 NGSVYLAYTGGCAA-LAAELIKEVKAVHWLDLGMPEAVWVLRVEEFGPLIVGIDTKGKDI 175

Query: 535 FQQIVNKQCANCTK 548
           F ++  K      K
Sbjct: 176 FAEVREKAQKQLEK 189


>UniRef50_A1RT45 Fumarase beta subunit n=8 Tax=Thermoprotei RepID=A1RT45_PYRIL
          Length = 211

 Score =  224 bits (572), Expect = 6e-57,   Method: Composition-based stats.
 Identities = 57/202 (28%), Positives = 104/202 (51%), Gaps = 7/202 (3%)

Query: 351 RQAGEGEAVKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKEL 410
            +  E       L  P+      +++  +   + ++G I+  RD AH ++ E ++ G++L
Sbjct: 4   NKLMELNMPTYYLKTPLS--TEDIAKLRIGDTVYISGVIVSARDSAHKRMLEYVERGEKL 61

Query: 411 PQYIKDHPIYYAGPA--KTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQ 468
           P  +K   IY+AGP   KT  G+   S+GPTT+ RM+++   +    G  +++ KG   +
Sbjct: 62  PVDLKGGVIYHAGPVAKKTDRGWEIISMGPTTSARMETFEADVIEKLGVKLVVGKGGMGK 121

Query: 469 QVTDACHKHGGFYLGSIGGPAAVLAQQSIKHLECVAYPELG-MEAIWKIEVEDF-PAFIL 526
           +  +A  KH   Y    GG   VLA ++IK +  V + +LG  EA+W +EVE+F P  I+
Sbjct: 122 RTAEAMKKHVAAYAIFTGGAG-VLAAKAIKRVIDVYWLDLGIAEAMWVLEVENFGPLTIM 180

Query: 527 VDDKGNDFFQQIVNKQCANCTK 548
           +D  G +++ +   +      +
Sbjct: 181 IDPTGRNYYDEQREEARRRVPE 202


>UniRef50_D1BP97 Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit
           n=5 Tax=Veillonellaceae RepID=D1BP97_VEIPT
          Length = 186

 Score =  224 bits (571), Expect = 7e-57,   Method: Composition-based stats.
 Identities = 66/188 (35%), Positives = 103/188 (54%), Gaps = 5/188 (2%)

Query: 358 AVKVDLNRPMKEILAQL-SQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKD 416
           A  + +N   +E   +   +  V   + +TG I   RD AH  + E +  G++LP    +
Sbjct: 2   AESIRINT--EEYNEEFSRKLKVGDSVLITGKIYSARDAAHKVMTEALARGEKLPIDWTN 59

Query: 417 HPIYYAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHK 476
             +YY GP     G P GS GPTT+GRMD+Y   +    G   M+ KG+R  +V ++  K
Sbjct: 60  KFVYYLGPTPAKPGDPIGSAGPTTSGRMDAYTPTMLDQ-GIKGMIGKGSRKPEVVESMKK 118

Query: 477 HGGFYLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQ 536
           +G  Y  ++GG AA++A +SIK  E +AY ELG EA+ ++ VEDFP  ++ D +GN+F++
Sbjct: 119 NGCTYFAAVGGAAALIA-KSIKKYEVLAYGELGPEALAELTVEDFPCIVVGDTEGNNFYE 177

Query: 537 QIVNKQCA 544
                   
Sbjct: 178 LGQKPYRK 185


>UniRef50_C9RML3 Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit
           n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85
           RepID=C9RML3_FIBSS
          Length = 281

 Score =  222 bits (566), Expect = 2e-56,   Method: Composition-based stats.
 Identities = 51/293 (17%), Positives = 91/293 (31%), Gaps = 24/293 (8%)

Query: 46  ALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAKGVLPTC 105
            +     +    A    R   QK+        E   N  +V  Q L N+ +A K   P C
Sbjct: 3   DIEQKVCECLIQAGSTFR-EDQKEAYRRAIAKEPGTNSCWVMQQVLDNALVAEKNRGPLC 61

Query: 106 QDTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEVNTG---- 161
            DTG   I  + G      G     +  G+     +   R       D ++   +G    
Sbjct: 62  DDTGIPHIFIEVGPNRQVTGDVLAQIHAGIEAGLRKLPGRPMAILGDDYHRIDQSGGLNP 121

Query: 162 ---TNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRT 218
                 P+ I +  V+ D  +   +  GGG A +    +          +   +   +  
Sbjct: 122 DSGALAPSPILIKPVEEDVLRLTILMLGGGPAIRGITQRVFHKHSVQVVIDEIVARAIPA 181

Query: 219 LGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLE 278
           +    C P  +A  IG +  E     ++  +   YD                + E+ + E
Sbjct: 182 VSQLGCSPCTLAVGIGRSQFEATSMMMEAMAKGNYD-------------FQSEFEKTITE 228

Query: 279 EAQKLGLGA-QFGGKYFAHDIRVIRLPRHGASC-PVGMGVSCSAD-RNIKAKI 328
              +  +GA   GGK           P+  +    V +   C  + R    ++
Sbjct: 229 RVNESNVGALGLGGKTSVLATFAKVGPQRASGVRIVALRPCCCFEPRRATVEL 281


>UniRef50_D0TAD5 Fumarate hydratase n=1 Tax=Bacteroides sp. 2_1_33B
           RepID=D0TAD5_9BACE
          Length = 286

 Score =  222 bits (565), Expect = 3e-56,   Method: Composition-based stats.
 Identities = 56/297 (18%), Positives = 102/297 (34%), Gaps = 29/297 (9%)

Query: 43  EPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAKGVL 102
             E +  L      +A    R   +K+    +   E +E  K+V    L N+E A K   
Sbjct: 4   NYEKIVSLVCDTLVEAGSTFR-EDKKKAYKRVIASEDNERAKWVLETVLANAEAAEKNHS 62

Query: 103 PTCQDTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEVNTG- 161
           P C DTG   +V + GQ     G   + + +G+         R       D ++   +G 
Sbjct: 63  PLCDDTGIPHMVLEVGQDAAVTGRMLDAIREGIAEGLRRLPGRPMGIMGDDSHRIDQSGG 122

Query: 162 ---TNL---PAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTP---GKLKNFL 212
               +    PA I +     +  +   +  GGG A +   Y+      T     ++ N+ 
Sbjct: 123 LNPDSAGVEPAPILIRRCQDNVIRLHILMFGGGPAIRAKTYRVFHKHNTQVVLDEIVNWA 182

Query: 213 VEKMRTLGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQL 272
            E +  LG   C P  +A  +G +  E     ++                 G+     ++
Sbjct: 183 TEGVAQLG---CSPCTLAVGVGRSHFEATSMMLQA-------------QVDGRYDFQSEM 226

Query: 273 EQELLEEAQKLGLGA-QFGGKYFAHDIRVIRLPRHGASC-PVGMGVSCSADRNIKAK 327
           EQE+     +  +G     GK       +   P+  +    V +  +C  +  I + 
Sbjct: 227 EQEITRRVNEANIGPLGLHGKTSVIATFMKVGPQRASGVRIVCVRPTCCFEPRIASV 283


>UniRef50_Q1LBZ6 Hydro-lyases, Fe-S type, tartrate/fumarate subfamily, beta region
           n=3 Tax=Burkholderiales RepID=Q1LBZ6_RALME
          Length = 187

 Score =  221 bits (564), Expect = 5e-56,   Method: Composition-based stats.
 Identities = 57/188 (30%), Positives = 92/188 (48%), Gaps = 4/188 (2%)

Query: 360 KVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHPI 419
              L  P+ E    + Q  V   + L+GTI + RD AH +  + +  G+ LP  +K   +
Sbjct: 3   THRLTTPLTE--EAIRQLNVGDEVLLSGTIYMARDAAHKRFVDTLARGEPLPVDLKGQVV 60

Query: 420 YYAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHGG 479
           +Y GP  T  G+  G + PT+A RMD Y  +L    G    + KG+R   +  +C  +  
Sbjct: 61  FYGGPGPTKPGHVIGVVAPTSAYRMDPYATVLF-EYGVKGAIGKGDRGDAIRASCKSNTA 119

Query: 480 FYLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQIV 539
               +IGG +A L    IK  E +AY +L  EA+ ++ +EDFP  +  D +G D +++ V
Sbjct: 120 VCFSAIGGISATLF-SCIKSAEIIAYEDLKTEAVQRLVIEDFPLLVTNDAQGRDMYEEEV 178

Query: 540 NKQCANCT 547
            +      
Sbjct: 179 TRFKKLLN 186


>UniRef50_Q0W346 Fumarate hydratase (Fumarase), beta subunit n=1 Tax=uncultured
           methanogenic archaeon RC-I RepID=Q0W346_UNCMA
          Length = 194

 Score =  219 bits (557), Expect = 3e-55,   Method: Composition-based stats.
 Identities = 59/192 (30%), Positives = 95/192 (49%), Gaps = 8/192 (4%)

Query: 359 VKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHP 418
           ++  L  P+               + LTGT+I  RD AH ++ E     K LP  ++   
Sbjct: 1   MEHRLRTPVS--AETARSLHAGDTVFLTGTMITARDKAHIRMAEYFSGEKPLPFSLEGAV 58

Query: 419 IYYAGPAKT--PAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHK 476
           I++  P       G+   ++GPTT+ RM+     + +H G+ +++ KG    +   A H 
Sbjct: 59  IFHGAPIVRQKADGWEMVAIGPTTSARMNDLEPPVIAH-GARMIVGKGGMDSRTLHALHD 117

Query: 477 HGGFYLGSIGGPAAVLAQQSIKHLECVAYPELGM-EAIWKIEVEDF-PAFILVDDKGNDF 534
           HG  YL   GG AAVL  + +K +  V + +LGM EA+W +EVEDF P  + +D   +D 
Sbjct: 118 HGSVYLSMTGG-AAVLGARMVKRVAGVEWTDLGMAEAVWVLEVEDFGPLTVTMDAHLHDL 176

Query: 535 FQQIVNKQCANC 546
           +Q + N+   N 
Sbjct: 177 YQDVRNRVSENI 188


>UniRef50_B2TIM0 Fumarate hydratase, class I n=18 Tax=Bacteria RepID=B2TIM0_CLOBB
          Length = 185

 Score =  218 bits (555), Expect = 6e-55,   Method: Composition-based stats.
 Identities = 66/188 (35%), Positives = 104/188 (55%), Gaps = 4/188 (2%)

Query: 359 VKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHP 418
           +++ L+ P+     ++ +      + L+G I   RD AH +L EL+D  ++LP  I +  
Sbjct: 1   MEMKLHTPLTS--EKILKLKAGDTVLLSGIIYSARDAAHKRLIELLDKDEKLPLSIDNEI 58

Query: 419 IYYAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHG 478
           IYY GP+    G   GS GPTT+ RMDSY   L    G   M+ KG R+++V  +  K+ 
Sbjct: 59  IYYVGPSPAKPGSVIGSAGPTTSYRMDSYAPRLLDL-GLKGMIGKGARNEKVIKSIRKNK 117

Query: 479 GFYLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQI 538
             Y G+IGG AA++A+  +K  E +AY +LG EAI K+EV+D P  +++D  GN+ ++  
Sbjct: 118 AIYFGAIGGAAALIAKSIVKS-EIIAYEDLGAEAIRKMEVKDMPLVVIIDSAGNNLYEIG 176

Query: 539 VNKQCANC 546
                   
Sbjct: 177 QKDYLDTL 184


>UniRef50_C8QYN2 Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit
           n=1 Tax=Desulfurivibrio alkaliphilus AHT2
           RepID=C8QYN2_9DELT
          Length = 202

 Score =  217 bits (553), Expect = 9e-55,   Method: Composition-based stats.
 Identities = 63/186 (33%), Positives = 102/186 (54%), Gaps = 4/186 (2%)

Query: 362 DLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHPIYY 421
            +  P    +  +++      +SL+G +  GRD  H +L  L+D G+ LP  ++   +YY
Sbjct: 16  RVEVPFNPAV--VAELKAGELVSLSGVLYTGRDQTHRRLCALLDEGRPLPVDLRGQLLYY 73

Query: 422 AGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHGGFY 481
            GP     G   G+ GPTT+ RMD+Y   L    G    + KG RS++V  A   HG  Y
Sbjct: 74  VGPTPALPGRVIGAAGPTTSYRMDAYTPRLLEL-GLTATMGKGPRSEEVRQAMLAHGAIY 132

Query: 482 LGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQIVNK 541
           L +IGG  A+L+ + I+  E VA+ + G EA+++ EVE+FPA ++ D  GNDF++++ + 
Sbjct: 133 LATIGGAGALLS-RCIRKSELVAFADAGAEAMFRFEVENFPAVVINDLAGNDFYRRVSDH 191

Query: 542 QCANCT 547
              +  
Sbjct: 192 GAPHLA 197


>UniRef50_B1I607 Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit
           n=1 Tax=Candidatus Desulforudis audaxviator MP104C
           RepID=B1I607_DESAP
          Length = 187

 Score =  217 bits (552), Expect = 1e-54,   Method: Composition-based stats.
 Identities = 66/186 (35%), Positives = 96/186 (51%), Gaps = 4/186 (2%)

Query: 360 KVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHPI 419
           K  +N P+ +    ++   V   +SL G +    D AH  L + I  GK+LP  + +  I
Sbjct: 3   KKQINTPLTD--EVIADLHVGDHVSLNGKLYTVGDAAHKSLVQYIGQGKQLPFSLANQVI 60

Query: 420 YYAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHGG 479
           YYA     P G   GS+GPTTA RMD Y   L +  G   ++AKG RS +VT A  +H  
Sbjct: 61  YYAVATPPPPGRIVGSVGPTTATRMDCYTPTLLAQ-GLKGVVAKGYRSAEVTQAMREHRA 119

Query: 480 FYLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQIV 539
            Y G++ G AA+L+ + IK +   A+P LG EA+++  V DFP  ++ D  G D   +  
Sbjct: 120 VYFGAVCGVAALLS-RYIKSVRLAAFPGLGAEAVYEYTVADFPVVVINDIHGGDLHLEGR 178

Query: 540 NKQCAN 545
                N
Sbjct: 179 RVYALN 184


>UniRef50_B1L7M7 Tartrate dehydratase beta subunit/Fumarate hydratase class I,
           C-terminal domain protein n=1 Tax=Candidatus Korarchaeum
           cryptofilum OPF8 RepID=B1L7M7_KORCO
          Length = 199

 Score =  217 bits (552), Expect = 1e-54,   Method: Composition-based stats.
 Identities = 56/189 (29%), Positives = 93/189 (49%), Gaps = 9/189 (4%)

Query: 360 KVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKE--LPQYIKDH 417
           +  L  P+ E   Q+ +  V   + L G II GRD  H +  EL   G++  +P  ++  
Sbjct: 3   EYRLRTPVTE--EQVRKLKVGDVVYLDGIIITGRDQVHRRALELASKGEKDKVPVKLEGM 60

Query: 418 PIYYAGPAKTP--AGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACH 475
            +Y+ GP        +     GPTT+ RM+S         G  +++ KG   ++ T A  
Sbjct: 61  ALYHCGPIVGKVDGEWKIYGFGPTTSARMESVEADFIREFGVRLIIGKGGLFERTTQAMK 120

Query: 476 KHGGFYLGSIGGPAAVLAQQSIKHLECVAYPELG-MEAIWKIEVEDF-PAFILVDDKGND 533
           ++G  YL   GG  +VLA  ++K +  V + +LG  EA+W +EVE+F P  + +D  GN+
Sbjct: 121 EYGAAYLAYPGG-VSVLATNAVKRVVDVHWLDLGVPEAMWVVEVENFGPTMVAIDSHGNN 179

Query: 534 FFQQIVNKQ 542
            F  ++   
Sbjct: 180 LFLDVLQNV 188


>UniRef50_A5UKC4 Fumarate hydratase, alpha subunit n=4 Tax=Methanobrevibacter
           RepID=A5UKC4_METS3
          Length = 290

 Score =  215 bits (549), Expect = 2e-54,   Method: Composition-based stats.
 Identities = 54/299 (18%), Positives = 95/299 (31%), Gaps = 33/299 (11%)

Query: 46  ALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAKGVLPTC 105
            +      A   AS  L    +          E +EN  +   Q L N ++A+K   P C
Sbjct: 2   DIIEDVSNAIIKASTNLS-EDKFNALKKAISVEDNENALWALNQILENYKVASKTKFPLC 60

Query: 106 QDTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEVNTG--TN 163
            DTG   ++ + G++    G     +++G+         R       D+ +   +    N
Sbjct: 61  DDTGIPHVIIEIGEKREITGELIAQINEGIERGLNNLPARPMAVKGNDVERIEQSKGLYN 120

Query: 164 LPAQ-------IDLYAVDG--------DEYKFLCVAKGGGSANKTYLYQETKALLTPGKL 208
            P Q       ID ++ D         D      + +GGG   +   Y+          +
Sbjct: 121 RPGQMKAASFLIDSFSEDSTYKRNISPDTLNIHFILEGGGPEIRAKTYRVYHKRSIENVI 180

Query: 209 KNFLVEKMRTLGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFR 268
              +     +L    C P   A  IG T  E +              L  +   +G    
Sbjct: 181 GTAIGWLSESLKMLGCTPSVPAVGIGRTHYEAS-------------SLLLKSIVYGNLDS 227

Query: 269 DVQLEQELLEEAQKLGLGA-QFGGKYFAHDIRVIRLPRHGASC-PVGMGVSCSADRNIK 325
              LE  + ++  +  +G   FGGK       V    +  +    V +  SC  +  + 
Sbjct: 228 QSDLENYVTQKLNETNIGPLGFGGKTTVLGSFVNVGNQRASGVRIVSVRPSCFVEPRVA 286


>UniRef50_B5YEU6 Fumarate hydratase, beta subunit n=2 Tax=Dictyoglomus
           RepID=B5YEU6_DICT6
          Length = 174

 Score =  214 bits (546), Expect = 6e-54,   Method: Composition-based stats.
 Identities = 65/176 (36%), Positives = 102/176 (57%), Gaps = 4/176 (2%)

Query: 361 VDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHPIY 420
             ++ P  E + +L +  V   + L G +   RD A  ++ ++++ G + P  +KD  IY
Sbjct: 2   KKIHLP--EDIGKLEEISVGEWILLNGALYSARDQACKRIVDMLEKGLKPPINLKDIIIY 59

Query: 421 YAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHGGF 480
           + GP+  P G   GS GPTT+ RMD +V  L    G    + KG R ++V +A  K+ GF
Sbjct: 60  HMGPSPAPPGRVVGSAGPTTSKRMDPFVAKLMK-NGVKGFIGKGLRGREVIEAIRKYKGF 118

Query: 481 YLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQ 536
           YL ++GG  A L  + IK ++ VA+PELG EA++ +EV DFP  + +D KGN F++
Sbjct: 119 YLVTVGGAGAYLGDR-IKSMKVVAFPELGPEAVYYLEVLDFPVLMAIDSKGNSFWE 173


>UniRef50_Q3YXI1 L(+)-tartrate dehydratase subunit beta n=108 Tax=Bacteria
           RepID=TTDB_SHISS
          Length = 201

 Score =  213 bits (543), Expect = 1e-53,   Method: Composition-based stats.
 Identities = 54/191 (28%), Positives = 89/191 (46%), Gaps = 10/191 (5%)

Query: 359 VKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHP 418
           +K  L  P+K     L    V   + LTGT++  RD+ H +L EL    + +P  +    
Sbjct: 1   MKKILTTPIK--AEDLQDIRVDDVIYLTGTLVTCRDVCHRRLIEL---KRPIPYDLNGKA 55

Query: 419 IYYAGPAKTPAG--YPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHK 476
           I++AGP     G  +   S+GPTT+ RM+S+        G  +++ KG       + C K
Sbjct: 56  IFHAGPIVRKNGDKWEMVSVGPTTSMRMESFEREFIEQTGVKLVVGKGGMGPLTEEGCQK 115

Query: 477 HGGFYLGSIGGPAAVLAQQSIKHLECVAYPELGM-EAIWKIEVEDF-PAFILVDDKGNDF 534
               ++    G  AVLA   ++ +E V + ELGM E++W   V++F P  + +D  GN+ 
Sbjct: 116 FKALHVIFPAGC-AVLAATQVEEIEEVHWTELGMPESLWVCRVKEFGPLIVSIDTHGNNL 174

Query: 535 FQQIVNKQCAN 545
             +        
Sbjct: 175 IAENKKLFAER 185


>UniRef50_Q30V65 Hydro-lyases, Fe-S type, tartrate/fumarate subfamily, beta region
           n=3 Tax=Deltaproteobacteria RepID=Q30V65_DESDG
          Length = 181

 Score =  213 bits (543), Expect = 1e-53,   Method: Composition-based stats.
 Identities = 65/174 (37%), Positives = 94/174 (54%), Gaps = 4/174 (2%)

Query: 362 DLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHPIYY 421
            L  P++     + Q      + L+G I   RD AH ++ E +D+G   P   +   +YY
Sbjct: 5   HLTTPLRS--EDVLQLRAGDVVLLSGDIYTARDAAHKRIMEQLDSGGTPPFPPEGAVVYY 62

Query: 422 AGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHGGFY 481
            GPA  P G P GS GPTT+GRMDSY   + +  G    + KG R   V +A  +HG  Y
Sbjct: 63  VGPAPAPPGRPIGSAGPTTSGRMDSYTPRMLAL-GVRATIGKGKRCDAVRNAMCEHGAVY 121

Query: 482 LGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFF 535
           LG+ GG  A+L+Q  +   E VAY ELG EA+ +++V DFP  ++ D  G + +
Sbjct: 122 LGATGGAGALLSQ-CVLAAEVVAYEELGPEAVRRLKVRDFPLLVINDACGGELY 174


>UniRef50_D2RKV4 Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit
           n=15 Tax=Bacteria RepID=D2RKV4_ACIFE
          Length = 206

 Score =  212 bits (540), Expect = 3e-53,   Method: Composition-based stats.
 Identities = 58/198 (29%), Positives = 92/198 (46%), Gaps = 13/198 (6%)

Query: 358 AVKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDH 417
           A KV L+ P+K     +    +   + LTG I   RD+AH +L E    G++LP  ++  
Sbjct: 2   ANKVVLHTPIKS--EDIENLKIGDIVYLTGKITTCRDVAHRRLIE---EGRKLPVDLEGG 56

Query: 418 PIYYAGPAKTP-----AGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTD 472
            I++AGP   P       Y   S+GPTT+ RM+ +        G  +++ KG   Q   D
Sbjct: 57  AIFHAGPIVRPIEGKENAYEMVSIGPTTSMRMEKFEKDFIPQTGVKLIVGKGGMGQDTMD 116

Query: 473 ACHKHGGFYLGSIGGPAAVLAQQSIKHLECVAYPELGM-EAIWKIEVEDF-PAFILVDDK 530
           AC K+   +     G  AV++    K +    + +LGM E +W  EVE+  P  + VD K
Sbjct: 117 ACQKYKTIFCVFPAGC-AVVSAVHFKKIIDAQWKDLGMPETLWTSEVEELGPLIVAVDTK 175

Query: 531 GNDFFQQIVNKQCANCTK 548
           G + F++          +
Sbjct: 176 GGNLFEENKKTYKKRAEE 193


>UniRef50_C0CW47 Putative uncharacterized protein n=1 Tax=Clostridium asparagiforme
           DSM 15981 RepID=C0CW47_9CLOT
          Length = 197

 Score =  210 bits (536), Expect = 7e-53,   Method: Composition-based stats.
 Identities = 61/195 (31%), Positives = 97/195 (49%), Gaps = 9/195 (4%)

Query: 359 VKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHP 418
            K  L  P+KE    + +  +   + LTG I   RD+ H K++EL+DAG+ LP+      
Sbjct: 2   DKKVLTMPLKE--EDVRELKIGDVVYLTGHIYTARDMGHLKIRELLDAGQPLPKDFTGAA 59

Query: 419 IYYAGPA---KTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACH 475
           I++AGP         +    +GPTT+ RM+ + D +    G   ++ KG   +   DAC 
Sbjct: 60  IFHAGPVCLKNEDGSWRLNVIGPTTSIRMEPHAD-VVGKMGIKAVIGKGGMEKGTLDACE 118

Query: 476 KHGGFYLGSIGGPAAVLAQQSIKHLECVAYPELGM-EAIWKIEVEDF-PAFILVDDKGND 533
           K+G  YL +  G AA LAQ  IK +  V + E+GM EA+W +E  +F P  + +D   N 
Sbjct: 119 KYGYVYLQAAPGCAAKLAQ-GIKSVYDVTWFEMGMPEALWDLEAVEFGPLVVGMDTHQNS 177

Query: 534 FFQQIVNKQCANCTK 548
            ++ +         +
Sbjct: 178 IYKNLKEAALKKLDE 192


>UniRef50_C7IGU5 Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit
           n=1 Tax=Clostridium papyrosolvens DSM 2782
           RepID=C7IGU5_9CLOT
          Length = 204

 Score =  209 bits (533), Expect = 2e-52,   Method: Composition-based stats.
 Identities = 56/194 (28%), Positives = 94/194 (48%), Gaps = 9/194 (4%)

Query: 360 KVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHPI 419
              L  P+K+    +++      + L+G +   RD+AH KLK+L+D+  +  + +    I
Sbjct: 3   TYYLKTPLKD--EDIAKLEAGDTVYLSGKLYTARDMAHYKLKKLLDSNGKFDEDLNGQAI 60

Query: 420 YYAGPAK----TPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACH 475
           ++AGP          Y   S+GPT++ RMD Y D++    G  I++ KG  S   T+A  
Sbjct: 61  FHAGPIISVNRESGEYKVISIGPTSSIRMDPYTDMV-GEMGVKILIGKGGMSDSTTEAMK 119

Query: 476 KHGGFYLGSIGGPAAVLAQQSIKHLECVAYPELGM-EAIWKIEVEDF-PAFILVDDKGND 533
           KH   YL +  G AAV  Q+  K        ++GM EA+W +E ++  P  + +D KG +
Sbjct: 120 KHTMVYLLAAHGCAAVHTQRVTKVTHQYWMDKIGMPEAMWVMECDNLGPLIVGIDSKGRN 179

Query: 534 FFQQIVNKQCANCT 547
            F++          
Sbjct: 180 LFEETRKNSKDMIE 193


>UniRef50_C1SNL1 Hydro-lyase family enzyme, Fe-S type, tartrate/fumarate subfamily
           n=1 Tax=Denitrovibrio acetiphilus DSM 12809
           RepID=C1SNL1_9BACT
          Length = 193

 Score =  209 bits (532), Expect = 2e-52,   Method: Composition-based stats.
 Identities = 50/188 (26%), Positives = 79/188 (42%), Gaps = 8/188 (4%)

Query: 361 VDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHPIY 420
           + L  P+ E   +     V   + LTGTI+  RD AH  + E  +    + +++KD  IY
Sbjct: 2   IKLTTPISE--EKARSLKVGDEVLLTGTIVTARDAAHKLMIE--ERPDFIREHLKDGVIY 57

Query: 421 YAGPAK---TPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKH 477
           + GP         Y   + GPTT+ R + Y   +        ++ KG    +  +   K 
Sbjct: 58  HCGPVVKQAENGEYSFVAAGPTTSSREEPYQAAVCEEYSVRAVIGKGGMGPKTAEGLKKV 117

Query: 478 GGFYLGSIGGPAAVLAQQSIKHLECVAYPELG-MEAIWKIEVEDFPAFILVDDKGNDFFQ 536
           G  YL ++GG  +++ +   K        E G  EA W  EVEDFP  + +D  G    +
Sbjct: 118 GAVYLHAVGGAGSLIGKMVKKVHTVYKLEEFGTPEAFWVCEVEDFPCVVTMDSHGGSLHK 177

Query: 537 QIVNKQCA 544
            I      
Sbjct: 178 DIAAASQK 185


>UniRef50_O27044 Fumarate hydratase, class I related protein n=2 Tax=cellular
           organisms RepID=O27044_METTH
          Length = 280

 Score =  208 bits (530), Expect = 4e-52,   Method: Composition-based stats.
 Identities = 46/293 (15%), Positives = 86/293 (29%), Gaps = 24/293 (8%)

Query: 46  ALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAKGVLPTC 105
            L    + A   AS    P   +       + E  E   ++    + N+ IA +   P C
Sbjct: 2   DLAGRVRDAIIQASTTYSPDVLRA-YERALEVEEDERSAWILELLIENARIAERERRPLC 60

Query: 106 QDTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDMYKEVNTG---- 161
            DTG   ++ + G+      G    L +GV     E   R       ++ +   +     
Sbjct: 61  DDTGIPHLIVEVGEDASLPAGFFNHLKRGVEEGLRELPGRPMAVRGDEVERIEQSRGLYS 120

Query: 162 ---TNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRT 218
                 PA   + +  G+  +   +  GGG   +    +           +  +      
Sbjct: 121 DPAKLPPAPFTVDSAPGEGVRIHVLMLGGGPEIRARTRRIFHRHSYRKVFEEVITWMKTE 180

Query: 219 LGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLE 278
           +    C P   A  IG T  E     ++  +              G       +E+ + E
Sbjct: 181 VPMLGCTPCIPAIGIGRTHFEATGLMLRAMA-------------TGNLDEQSWIEEHITE 227

Query: 279 EAQK-LGLGAQFGGKYFAHDIRVIRLPRHGASC-PVGMGVSCSAD-RNIKAKI 328
                       GG   A    +   P+  +    V M ++C  + R     +
Sbjct: 228 SLNSTGTGPLGLGGSTTALGAMIKVGPQRASGVRIVSMRLACCVEPRRATIDL 280


>UniRef50_Q0RXW9 L(+)-tartrate dehydratase beta subunit n=2 Tax=Bacteria
           RepID=Q0RXW9_RHOSR
          Length = 201

 Score =  207 bits (526), Expect = 1e-51,   Method: Composition-based stats.
 Identities = 48/197 (24%), Positives = 83/197 (42%), Gaps = 8/197 (4%)

Query: 354 GEGEAVKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQY 413
              E   + L  P+ E+        V   + L GT+   RD +  +L +  +  +     
Sbjct: 2   ATEEQRTLRLRAPLTEV--DARDLRVGDEVWLDGTVWGIRDASLIRLFDQGERPEGT--D 57

Query: 414 IKDHPIYYAGPAKTPAG--YPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVT 471
            +     +  P+    G  Y   S+G TT+ RMD +     +  G+  ++ KG  S +  
Sbjct: 58  FEGALFIHTAPSVRKEGDRYLPVSVGTTTSMRMDRFTRGCLADIGARAIIGKGGLSDESL 117

Query: 472 DACHKHGGFYLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDF-PAFILVDDK 530
               + GG YL   GG A+      I+ +E V + +L  E +WK  V+DF P F+ +D  
Sbjct: 118 SHFQEFGGVYLAITGGAASW-ETLQIEEIEEVLWEDLMPECLWKFRVKDFGPLFVTMDSV 176

Query: 531 GNDFFQQIVNKQCANCT 547
           GN  ++Q+  +      
Sbjct: 177 GNSAYEQVRARAQQRLA 193


>UniRef50_B5F039 Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta region
           n=16 Tax=Salmonella enterica RepID=B5F039_SALA4
          Length = 181

 Score =  206 bits (524), Expect = 2e-51,   Method: Composition-based stats.
 Identities = 65/184 (35%), Positives = 99/184 (53%), Gaps = 4/184 (2%)

Query: 361 VDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHPIY 420
           ++L  P+ +   +     V   L LTG     RD AH K++  +  G++ P   ++  IY
Sbjct: 2   MELTLPLTK--EKAKTLKVGDILFLTGFAYTCRDAAHKKIEVALSNGEKSPVDFQNQTIY 59

Query: 421 YAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHGGF 480
           YAGP     G P GS GPTTA RMD +V+++    G+   L KG+R+  V + C K+GG 
Sbjct: 60  YAGPCPARPGLPIGSNGPTTAARMDPFVEMMFQQ-GATAFLGKGDRADYVAELCKKYGGV 118

Query: 481 YLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQIVN 540
            L  IGG +A +  + +K +E VAY ELG E+I K+  + +   + +D +GN   +Q V 
Sbjct: 119 SLLGIGGASA-INTKHVKSVEIVAYEELGTESIKKLYFDRYRVIVGIDSEGNTLQKQEVP 177

Query: 541 KQCA 544
           K   
Sbjct: 178 KYAK 181


>UniRef50_O27932 Fumarate hydratase, class I related protein n=5
           Tax=Methanobacteriaceae RepID=O27932_METTH
          Length = 225

 Score =  205 bits (522), Expect = 3e-51,   Method: Composition-based stats.
 Identities = 49/190 (25%), Positives = 88/190 (46%), Gaps = 25/190 (13%)

Query: 359 VKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHP 418
           +++ L  P+     ++++  V   + + G I   RD AH ++ E     +  P  I+   
Sbjct: 4   MEIKLETPLS---EEVTELRVGDVVYINGRIFTARDRAHKRILE-----RGAPFDIEGSV 55

Query: 419 IYYAGPAKT-------------PAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGN 465
           I++AGP                        +GPTT+GRM+ +   +    G   ++ KG 
Sbjct: 56  IFHAGPIIRFNEEPNTTAESIRDPQAELVVVGPTTSGRMNPFQPEVLGL-GVRAVIGKGG 114

Query: 466 RSQQVTDACHKHGGFYLGSIGGPAAVLAQQSIKHLECVAYPELG-MEAIWKIEVEDF-PA 523
              +   A  ++G  YL ++GG AA+    ++K +  V + +LG  EAIW++EVE+F P 
Sbjct: 115 MDDRTGSALRRYGAVYLAAVGGCAALYG-SAVKGIRAVHWLDLGVPEAIWELEVEEFGPL 173

Query: 524 FILVDDKGND 533
            + +D  G  
Sbjct: 174 IVAMDSTGRS 183


>UniRef50_B2KBV4 Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit
           n=1 Tax=Elusimicrobium minutum Pei191 RepID=B2KBV4_ELUMP
          Length = 171

 Score =  205 bits (522), Expect = 3e-51,   Method: Composition-based stats.
 Identities = 64/177 (36%), Positives = 94/177 (53%), Gaps = 8/177 (4%)

Query: 361 VDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHPIY 420
           + L  P+   +  L +      + L+G I   RD AH +L E     K  P ++K   +Y
Sbjct: 2   IKLKTPLT--VKDLKKIKTGDSVLLSGVIYTARDKAHKQLLE----EKVFPSFLKGQIVY 55

Query: 421 YAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHGGF 480
           YAGPA  P G   GS+GPTT+GRMD +V  + S    +  + KG  S +  +A       
Sbjct: 56  YAGPAPAPKGKVVGSIGPTTSGRMDKFVKQILSKSDIIATIGKGMLSAEAKEAMVG-KAV 114

Query: 481 YLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQ 537
           Y  ++GG  A++AQ  +K  ECV Y +LG EAI+K+EVE+ P  +  D  G+D F +
Sbjct: 115 YFAAMGGAGALIAQ-CVKKCECVLYKDLGAEAIYKLEVENMPLIMAFDLYGSDIFWR 170


>UniRef50_C8WG73 Fe-S type hydro-lyase tartrate/fumarate beta region n=2
           Tax=Coriobacteriaceae RepID=C8WG73_EGGLE
          Length = 181

 Score =  203 bits (517), Expect = 1e-50,   Method: Composition-based stats.
 Identities = 70/183 (38%), Positives = 94/183 (51%), Gaps = 5/183 (2%)

Query: 357 EAVKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLK-ELIDAGKELPQYIK 415
            A ++ L  P     A L++        LTG +   RD  H +L  EL  AG  LP  + 
Sbjct: 3   SADRIRLALPF--DRAALARLEAGDSCLLTGPLYTLRDAGHVRLLAELEAAGGALPYGLD 60

Query: 416 DHPIYYAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACH 475
              I+YAGP    AG P G++GPTTA RMD +        G    + KG RS +V DAC 
Sbjct: 61  GQAIFYAGPTPEAAGRPFGAVGPTTASRMD-FAAPALHRAGVAATVGKGRRSSEVRDACR 119

Query: 476 KHGGFYLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFF 535
             G  Y  + GG AA LA + +   E VAY +LG EA+ +I+V DFP F+ VD +G D +
Sbjct: 120 ATGSVYFVACGGAAAYLA-KCVASSETVAYDDLGTEALRRIDVVDFPVFVGVDVRGRDVY 178

Query: 536 QQI 538
             +
Sbjct: 179 DLV 181


>UniRef50_B0VIF2 Tartrate dehydratase beta subunit (TtdB)/fumarate hydratase class
           I, beta chain (C-terminal) n=1 Tax=Candidatus
           Cloacamonas acidaminovorans RepID=B0VIF2_9BACT
          Length = 167

 Score =  203 bits (516), Expect = 1e-50,   Method: Composition-based stats.
 Identities = 54/168 (32%), Positives = 89/168 (52%), Gaps = 4/168 (2%)

Query: 360 KVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHPI 419
                 P+    A ++   +S ++ LTG +   RD+AH ++ +++  G++LP  + +  +
Sbjct: 3   TYRFTLPL--CPADIAPLHISDKVLLTGCLFTARDVAHKRMVDILKRGEKLPLNLAETTL 60

Query: 420 YYAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHGG 479
           +Y GP+    G   G++GPTT+ RMD Y  LL    G  +M+ KG RS +V  A    G 
Sbjct: 61  FYCGPSPARPGNICGAIGPTTSSRMDIYTPLLI-QNGLRVMIGKGERSIEVQKAIMDFGA 119

Query: 480 FYLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILV 527
            Y    GG +A L+Q  +   E   + ELG EAI K+ V+D P ++ +
Sbjct: 120 IYFVMPGGISAYLSQHIV-SCETFLWQELGPEAIHKLWVQDIPVYVAI 166


>UniRef50_C9KL19 L(+)-tartrate dehydratase subunit beta n=1 Tax=Mitsuokella
           multacida DSM 20544 RepID=C9KL19_9FIRM
          Length = 203

 Score =  202 bits (515), Expect = 2e-50,   Method: Composition-based stats.
 Identities = 52/194 (26%), Positives = 89/194 (45%), Gaps = 11/194 (5%)

Query: 360 KVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHPI 419
           K  L  P+    A L    V   + LTG +   RD+AH ++ E    G++LP  I+D  I
Sbjct: 3   KKVLTTPIS--AADLEDIHVGDVIYLTGELTTCRDVAHRRVIE---EGRKLPVDIRDGAI 57

Query: 420 YYAGPAKTPAG---YPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHK 476
            +AGP   P G   Y   ++GPTT+ RM+ + +      G  +++ KG         C  
Sbjct: 58  LHAGPIIRPRGEDDYEMVTVGPTTSMRMEKFEEAFIKETGVRLIIGKGGMGAGTMRGCRD 117

Query: 477 HGGFYLGSIGGPAAVLAQQSIKHLECVAYPELGM-EAIWKIEVEDF-PAFILVDDKGNDF 534
           +   +     G  AV+A   ++ +    + +LGM E +W  +V++F P  + +D  G++ 
Sbjct: 118 NKALHCVFPAGC-AVVAATCVEKILSANWKDLGMPETLWTCKVKEFGPLIVSIDTHGHNL 176

Query: 535 FQQIVNKQCANCTK 548
           F++          K
Sbjct: 177 FEENKVIFNERKDK 190


>UniRef50_A9BJS9 Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit
           n=9 Tax=Thermotogaceae RepID=A9BJS9_PETMO
          Length = 165

 Score =  199 bits (505), Expect = 3e-49,   Method: Composition-based stats.
 Identities = 57/166 (34%), Positives = 92/166 (55%), Gaps = 2/166 (1%)

Query: 370 ILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHPIYYAGPAKTPA 429
            + ++ +  +   L  TG +IV RD AH +L EL+    +LP  + +  ++YAGPA  P 
Sbjct: 2   KVNEIEKLKIGELLQYTGELIVMRDAAHQRLLELLSKNSQLPVDLNEKIVFYAGPANPPK 61

Query: 430 GYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHGGFYLGSIGGPA 489
               G++GPTT+ RMD Y++++    G +  + KG R+      C K+   Y  +  G A
Sbjct: 62  NSKIGAIGPTTSERMDKYLEMIFKL-GVLATVGKGKRNDLAVKLCIKYKRVYFITPSGAA 120

Query: 490 AVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFF 535
           A L+ + +K +  +A+ ELG EAI+ I V+DFP  + +D  GN  F
Sbjct: 121 AYLS-KCVKDIRVLAFAELGPEAIYNINVKDFPLMVAIDTSGNQIF 165


>UniRef50_C3PJK6 L-tartrate dehydratase n=19 Tax=Bacteria RepID=C3PJK6_CORA7
          Length = 213

 Score =  199 bits (505), Expect = 3e-49,   Method: Composition-based stats.
 Identities = 53/202 (26%), Positives = 86/202 (42%), Gaps = 17/202 (8%)

Query: 355 EGEAVKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYI 414
                   L  P+ +    L        + L G I+  RD+ H ++ EL   G+ELP  +
Sbjct: 2   SENTTAKTLTTPISQ--EDLQDIKAGDVIFLDGYIVTCRDVGHRRVVEL---GRELPLDL 56

Query: 415 KDHPIYYAGPAKTP---------AGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGN 465
           K   I +AGP               Y   S+GPTT+ RM+ +        G  +++ KG+
Sbjct: 57  KGGAILHAGPIMQKVEGTDRNGDEKYEVVSVGPTTSMRMEMFEYDFIEQTGVRLIVGKGS 116

Query: 466 RSQQVTDACHKHGGFYLGSIGGPAAVLAQQSIKHLECVAYPELGM-EAIWKIEVEDF-PA 523
                   C + G  +     G  AV+A   ++ +E   + ELGM EA+W + V+ F P 
Sbjct: 117 MGPNTEAGCKEFGALHCVFPAG-NAVIAATEVEEVEESYWRELGMPEALWVMRVKQFGPL 175

Query: 524 FILVDDKGNDFFQQIVNKQCAN 545
            + +D  GN+ + Q   +  A 
Sbjct: 176 IVSIDANGNNLYTQKKEEYNAR 197


>UniRef50_A9HYF7 L-tartrate dehydratase, subunit B n=3 Tax=Proteobacteria
           RepID=A9HYF7_BORPD
          Length = 203

 Score =  194 bits (494), Expect = 6e-48,   Method: Composition-based stats.
 Identities = 53/193 (27%), Positives = 84/193 (43%), Gaps = 15/193 (7%)

Query: 362 DLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHPIYY 421
           +L+ P+ E   Q     V   ++L  T+   RD ++     L D G+     +  H + +
Sbjct: 5   NLDMPITET--QARALRVGDTVTLQHTLFGIRDASY---IALFDQGRATRFDMNGHAVIH 59

Query: 422 AGPAKT--------PAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDA 473
             P           PAGY S  +G TT+ RM+ +   L    G  +++ KG   Q    A
Sbjct: 60  TAPNVRKVAVSARNPAGYESVCIGTTTSARMERFTGQLMRQCGVRLIVGKGGMQQGSRQA 119

Query: 474 CHKHGGFYLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDF-PAFILVDDKGN 532
             + GG YL  +GG AA L    I+ +E V   +L  E++WK  + DF P  + +D  G 
Sbjct: 120 FMEQGGAYLAIVGGTAA-LETTWIESIEDVDLDDLNPESLWKFRIRDFGPLLVAMDSHGG 178

Query: 533 DFFQQIVNKQCAN 545
             + Q+     A 
Sbjct: 179 SLYDQVAEDVAAR 191


>UniRef50_A4YFS6 Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit
           n=1 Tax=Metallosphaera sedula DSM 5348
           RepID=A4YFS6_METS5
          Length = 191

 Score =  194 bits (492), Expect = 1e-47,   Method: Composition-based stats.
 Identities = 53/189 (28%), Positives = 92/189 (48%), Gaps = 9/189 (4%)

Query: 362 DLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHPIYY 421
            L  P+KE +  +    +   + L+G I + RD    ++ E    G   P  +KD  +++
Sbjct: 3   KLETPLKEDV--VQSLRLGEEVYLSGKIYIMRDATLRRIFE---QGVAPPVNLKDQVVFF 57

Query: 422 AGPAKTPA--GYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHGG 479
             P+ T    GY   S+G TT+ RM+ Y+  L +  G   ++ KG  S+++     +   
Sbjct: 58  GAPSFTKDSNGYTILSVGVTTSQRMEKYIPRLLNELGVKGIVGKGELSERMNPEFSRAKS 117

Query: 480 FYLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDF-PAFILVDDKGNDFFQQI 538
            YL  +GG AA LA  SI+ +  V + +L  EA++++EV    PAF+ +D +G +   + 
Sbjct: 118 VYLLFVGGAAA-LATSSIQRVNKVWWEDLRGEALFEVEVNSLGPAFVAIDAQGGNLLMEN 176

Query: 539 VNKQCANCT 547
             K   N  
Sbjct: 177 REKVLRNLN 185


>UniRef50_A1HQH2 Fe-S type hydro-lyases tartrate/fumarate alpha region n=1
           Tax=Thermosinus carboxydivorans Nor1 RepID=A1HQH2_9FIRM
          Length = 216

 Score =  193 bits (491), Expect = 1e-47,   Method: Composition-based stats.
 Identities = 48/169 (28%), Positives = 73/169 (43%), Gaps = 3/169 (1%)

Query: 39  ILKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAA 98
           +  +E   +T    +   +A++ L P           + E S   K +  Q + N+ IA 
Sbjct: 1   MRTLEAAQITAAVAKLAVEANYNLSPD-IYDALVAGREKEESPLGKEILGQLVTNACIAR 59

Query: 99  KGVLPTCQDTGTAIIVGKKGQRVWTGGG-DEETLSKGVYNTYIEDNLRYSQNAALDMYKE 157
           +  +P CQDTG A++  + GQ V   GG   + ++ GV   Y E  LR S      ++  
Sbjct: 60  EEAMPICQDTGMAVVFVELGQDVHITGGSLADAVNAGVAKGYTEGYLRKSVVD-DPLFDR 118

Query: 158 VNTGTNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPG 206
            NT  N PA + +  V GD+ K     KG GS N + L     A    G
Sbjct: 119 KNTQDNTPAILHVELVPGDKLKITLAPKGFGSENMSALKMFKPAEGVVG 167


>UniRef50_A7I689 Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit
           n=6 Tax=Euryarchaeota RepID=A7I689_METB6
          Length = 187

 Score =  193 bits (490), Expect = 2e-47,   Method: Composition-based stats.
 Identities = 53/185 (28%), Positives = 85/185 (45%), Gaps = 15/185 (8%)

Query: 360 KVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHPI 419
            + L  P+ +   ++       R+ L+GT+   RD AH ++       + +P   K   I
Sbjct: 5   TLQLTTPLGD---EVLSLMAGDRIELSGTVYTARDEAHLRM-----RKEGIPFDPKGAVI 56

Query: 420 YYAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHGG 479
           Y+ GP          + GPTT+ RM+S    L    G   ++ KG     V +     G 
Sbjct: 57  YHCGPVIKDN--KIIAAGPTTSARMNSLSGFLLD-AGVRGLIGKGGMDATVREQLRGRG- 112

Query: 480 FYLGSIGGPAAVLAQQSIKHLECVAYPELGM-EAIWKIEVEDFPAFILVDDKGNDFFQQI 538
            Y    GG AA+ A   I  L+ V +P+LGM EA+W+IE++  P  + +D +GND F ++
Sbjct: 113 VYFAFTGGCAALAASHMI--LKGVHFPDLGMAEAVWEIELDRLPLVVGIDAQGNDLFGKV 170

Query: 539 VNKQC 543
                
Sbjct: 171 REHAQ 175


>UniRef50_B4UMA9 Fe-S type hydro-lyase tartrate/fumarate beta region n=3
           Tax=Anaeromyxobacter RepID=B4UMA9_ANASK
          Length = 191

 Score =  187 bits (474), Expect = 1e-45,   Method: Composition-based stats.
 Identities = 49/186 (26%), Positives = 81/186 (43%), Gaps = 8/186 (4%)

Query: 359 VKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHP 418
           +   L  P   +   +        + L G I+ GR+ AH  L    D   ++ ++ +   
Sbjct: 1   MPKTLTLP--ALPEDVRGLAAGDEVLLRGRIVTGREAAHRYLATHDD--PQVRRWTEGAV 56

Query: 419 IYYAGPAKTP---AGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACH 475
           +Y+ GP        G+   + GP+ +GR +++   + +  G   +L KG    +  +A  
Sbjct: 57  LYHCGPVVARAPGGGWRFVAAGPSASGRQEAWEAEVIARYGLRGVLGKGGMGPRTLEALR 116

Query: 476 KHGGFYLGSIGGPAAVLAQQSIKHLECVAYPELG-MEAIWKIEVEDFPAFILVDDKGNDF 534
            HG  YL + GG A  LA+   + L+      LG  EAIW  EVEDFPA + +D  G   
Sbjct: 117 AHGAVYLHAAGGLAVSLARHVTRVLDVARLDALGVTEAIWLAEVEDFPAVVTMDAHGETL 176

Query: 535 FQQIVN 540
             +   
Sbjct: 177 HARGAE 182


>UniRef50_A7HKF0 Fe-S type hydro-lyase tartrate/fumarate beta region n=1
           Tax=Fervidobacterium nodosum Rt17-B1 RepID=A7HKF0_FERNB
          Length = 160

 Score =  184 bits (468), Expect = 6e-45,   Method: Composition-based stats.
 Identities = 52/159 (32%), Positives = 85/159 (53%), Gaps = 5/159 (3%)

Query: 371 LAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHPIYYAGPAKTPAG 430
              L +  V      TG +IV RD A  +L E+ D GK LP  +K+  ++YAGP  +   
Sbjct: 6   TETLKKLNVGEMFEYTGKLIVMRDAAQKRLVEMEDNGKTLPVELKNALVFYAGPTFSKGN 65

Query: 431 YPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHGGFYLGSIGGPAA 490
                +GPTT+ RMD +++      G +  + KG R+ +  +   K+   Y  +  G AA
Sbjct: 66  ---IIIGPTTSKRMDRFLE-FLGRHGVIGTIGKGERTPEGVETIKKYKMIYFVTPSGCAA 121

Query: 491 VLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDD 529
            L ++ IK  + VA+ +LG EA+++IEVE+FP  +++  
Sbjct: 122 YLGKK-IKSWKVVAFEDLGPEAVYEIEVENFPLLVVISA 159


>UniRef50_B8GKV9 Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit
           n=1 Tax=Methanosphaerula palustris E1-9c
           RepID=B8GKV9_METPE
          Length = 190

 Score =  180 bits (456), Expect = 1e-43,   Method: Composition-based stats.
 Identities = 54/176 (30%), Positives = 82/176 (46%), Gaps = 15/176 (8%)

Query: 361 VDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHPIY 420
           VDL  P+ +   +        R++L+G +   RD AH ++ +     + +P       IY
Sbjct: 2   VDLRTPLGD---EFLSLVAGDRVTLSGMVYTARDEAHLRMMD-----EGIPFDPVGAAIY 53

Query: 421 YAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHGGF 480
           + GP  +       + GPTT+ RM+     L    G  +++ KG    QV +     G  
Sbjct: 54  HCGPVISHD--RVIAAGPTTSARMNDLSGFLLDK-GVRVLIGKGGMGSQVVEQLRGRG-V 109

Query: 481 YLGSIGGPAAVLAQQSIKHLECVAYPELGM-EAIWKIEVEDFPAFILVDDKGNDFF 535
           YL   GG AA+ A     HL  V YP+LGM EA+W IE++  P  + +D  G D F
Sbjct: 110 YLAFTGGCAALAATHM--HLTGVFYPDLGMAEAVWAIELDHLPLVVGIDAAGGDLF 163


>UniRef50_B0NH77 Putative uncharacterized protein n=1 Tax=Clostridium scindens ATCC
           35704 RepID=B0NH77_EUBSP
          Length = 166

 Score =  172 bits (435), Expect = 5e-41,   Method: Composition-based stats.
 Identities = 52/186 (27%), Positives = 81/186 (43%), Gaps = 39/186 (20%)

Query: 359 VKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHP 418
           +   +  P+ + ++          + +TGTI   R                         
Sbjct: 19  MDKHITAPITKKVS--RTLRAGDYVYITGTIYTAR------------------------- 51

Query: 419 IYYAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHG 478
                      G   GS G TTA   D Y   L    G   M+ KG RS +V +A  ++G
Sbjct: 52  ----------EGRSIGSAGSTTASCRDRYALKLLDL-GLTAMIGKGKRSPEVLEAVKRNG 100

Query: 479 GFYLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQI 538
             YL ++GG  A+L+ + IK  E VAY +LG EAI K++VEDFPA ++ D +GN+ ++  
Sbjct: 101 SVYLAAVGGAGALLS-KCIKESEVVAYNDLGAEAIRKLKVEDFPAIVVADCEGNNLYETA 159

Query: 539 VNKQCA 544
           + +   
Sbjct: 160 IKEYQK 165


>UniRef50_B5Y8W5 Putative uncharacterized protein n=1 Tax=Coprothermobacter
           proteolyticus DSM 5265 RepID=B5Y8W5_COPPD
          Length = 258

 Score =  166 bits (421), Expect = 2e-39,   Method: Composition-based stats.
 Identities = 51/242 (21%), Positives = 85/242 (35%), Gaps = 20/242 (8%)

Query: 87  ALQFLRNSEIAAKGVLPTCQDTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRY 146
                 N +++ +  LP CQDTG   +V   G    T     E   K  +     D  R 
Sbjct: 35  LEVLEENLDLSNRLNLPVCQDTGVVTLVV--GHDSLTRDELLEI--KTAFENCFNDLARP 90

Query: 147 SQNAALDMYKEVNTGTNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPG 206
           S  +    + +   G +   Q+       D+     V  G G+    +L        +  
Sbjct: 91  SMLS-SPFFGQHPLGRH---QVCFLEEVRDKRGLGAVISGAGTETHCFLKV-YPGTASWE 145

Query: 207 KLKNFLVEKMRTLGTAACPPYHIAFVIGGTSAETNLKTVKLASAHYYDELPTEGNEHGQA 266
            + + L        + ACPP H    +GGT+AE     VK +   +       GN     
Sbjct: 146 TVVDDLQGWSSKRASLACPPVHFGVAVGGTAAEA----VKQSKLSFLF-----GNNFPTC 196

Query: 267 FRDVQLEQELLEEAQKLGLGAQFGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKA 326
           +      +EL+   +   +     G+ +A D+ +  LP H ++ PV M   C   R    
Sbjct: 197 YEHAY--EELVNALRASTVDPLKNGESWAGDVFLRILPTHMSAVPVSMSFMCWPYRAEWI 254

Query: 327 KI 328
            +
Sbjct: 255 DL 256


>UniRef50_UPI000190D92B fumarate hydratase class I, anaerobic n=10 Tax=Salmonella enterica
           subsp. enterica serovar Typhi RepID=UPI000190D92B
          Length = 136

 Score =  166 bits (420), Expect = 2e-39,   Method: Composition-based stats.
 Identities = 119/136 (87%), Positives = 129/136 (94%)

Query: 1   MSNKPFIYQAPFPMGKDNTEYYLLTSDYVSVADFDGETILKVEPEALTLLAQQAFHDASF 60
           MS K FIYQAPFPMG+D TEYYLLTSDYVSV++F+GE+IL VEP+ALTLLAQQAFHDASF
Sbjct: 1   MSKKEFIYQAPFPMGEDKTEYYLLTSDYVSVSEFNGESILNVEPQALTLLAQQAFHDASF 60

Query: 61  MLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAKGVLPTCQDTGTAIIVGKKGQR 120
           MLRP HQ+QVAAILHDPEASENDKYVALQFLRNSEIAAKG+LPTCQDTGTAII+GKKGQR
Sbjct: 61  MLRPEHQQQVAAILHDPEASENDKYVALQFLRNSEIAAKGILPTCQDTGTAIIMGKKGQR 120

Query: 121 VWTGGGDEETLSKGVY 136
           VWTGGGDE  LSKGV+
Sbjct: 121 VWTGGGDEAALSKGVF 136


>UniRef50_UPI0001C41F68 fumarate hydratase FumA4 n=1 Tax=Methanobrevibacter ruminantium M1
           RepID=UPI0001C41F68
          Length = 166

 Score =  163 bits (414), Expect = 1e-38,   Method: Composition-based stats.
 Identities = 40/177 (22%), Positives = 77/177 (43%), Gaps = 15/177 (8%)

Query: 361 VDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGK--ELPQYIKDHP 418
             +  P+ +    ++   +  ++SL+G +  GRD    KL + I+ G+  + P   K   
Sbjct: 2   KRITTPISDD--DINDLKIGDKISLSGKMYCGRDAVLPKLSKSIENGQEDKYPFDFKGMA 59

Query: 419 IYYAGPAKTPAGYPSGSLGPTTAGRMDSYVDL-LQSHGGSMIMLAKGNRSQQVTDACHKH 477
           I +         +    + PTT+ + +    +   S  G    + KG+ S +      K+
Sbjct: 60  IMHTA-------FSVAGIAPTTSNKAEIESSMEALSSAGVKFHIGKGSLSDETKKTLDKY 112

Query: 478 GGFYLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDF 534
              ++  +  P A L   ++   +CVAY E GMEA +++EV+D P  + +   G   
Sbjct: 113 NSIFI--VTPPVAALLTNNVISKKCVAYEEEGMEAFFELEVKDIPGIVAI-AHGKSL 166


>UniRef50_Q28K74 Fe-S type hydro-lyases tartrate/fumarate beta protein n=14
           Tax=Proteobacteria RepID=Q28K74_JANSC
          Length = 226

 Score =  163 bits (414), Expect = 1e-38,   Method: Composition-based stats.
 Identities = 34/204 (16%), Positives = 83/204 (40%), Gaps = 12/204 (5%)

Query: 353 AGEGEAVKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQ 412
               +  ++ L+         ++   +   + L+G +   R+  + +  E   A   +  
Sbjct: 3   PTPNKPREITLST--TPSAEAIADLRLGDVVYLSGLMYTAREGVYMRALE-DRANIPMEL 59

Query: 413 YIKDHPIYYAGP---AKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNR-SQ 468
             +    ++  P         +  G++  T + R   ++    +  G+ +++ KG   S+
Sbjct: 60  PAQSAANFHCSPAARINADGSFDMGAVTATASFRFAKWLPEWMAKTGAKLIVGKGGMTSK 119

Query: 469 QVTDACHKHGGFYLGSIG-GPAAVLAQQSIKHLECVAY-PELG-MEAIWKIEVEDF-PAF 524
              +    +G  YL ++G G  A+L  + ++++E V +  ELG  +A+W ++     P  
Sbjct: 120 DYKEYFVPNGAVYLSTVGYGTGALLG-RGVENVEAVHWNEELGIAQAMWVLKCNRMGPFI 178

Query: 525 ILVDDKGNDFFQQIVNKQCANCTK 548
           +  D  G+  F++   K   N  +
Sbjct: 179 VASDMNGDCLFERENAKIAENVAR 202


>UniRef50_A1WMD4 Fumarate hydratase class I beta subunit n=1 Tax=Verminephrobacter
           eiseniae EF01-2 RepID=A1WMD4_VEREI
          Length = 205

 Score =  159 bits (403), Expect = 2e-37,   Method: Composition-based stats.
 Identities = 38/191 (19%), Positives = 74/191 (38%), Gaps = 8/191 (4%)

Query: 363 LNRPMKEILAQLSQYPVSTRLSLTGTIIV-GRDIAHAKLKELIDAGKELPQYIKDHPIYY 421
           L  P+     ++    V   ++L G I V      H ++ + +  G+ LP  ++    ++
Sbjct: 5   LVLPLSRD--KVRALAVGDMVTLDGEITVSIGLQTHQRMVQAVGDGQALPVDLRAGAFFH 62

Query: 422 AGPAKTPAGYPSGSL--GPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHGG 479
                   G     L   P+T+ R ++++  L       +   KG        A    G 
Sbjct: 63  LSTCVRDTGDGPQPLYTNPSTSTRYNAWMPSLVRGLDLRLTGGKGGLDAASVQALRDTGC 122

Query: 480 FYLGSIGGPAAVLAQQSIKHLECVAYPELGME-AIWKIEVEDF-PAFILVDDKGNDFFQQ 537
            YL  +GG  A L  + ++ L    + E   +  +  + V  F PA + +D  GN  ++Q
Sbjct: 123 VYLSFLGG-GAPLLSRGLRGLVSSHWNEYISQFRLLTLRVAAFGPATVAIDAHGNSLYEQ 181

Query: 538 IVNKQCANCTK 548
           +  +  A   +
Sbjct: 182 LRGQAQARMPQ 192


>UniRef50_C9RML5 Fe-S type hydro-lyase tartrate/fumarate beta region n=3
           Tax=Bacteria RepID=C9RML5_FIBSS
          Length = 167

 Score =  155 bits (392), Expect = 4e-36,   Method: Composition-based stats.
 Identities = 41/178 (23%), Positives = 78/178 (43%), Gaps = 15/178 (8%)

Query: 361 VDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAG--KELPQYIKDHP 418
           ++L  P  E    +++  V   +S++G I  GRD    K+ +  + G   E+   ++   
Sbjct: 2   IELTTPFSE--EDIAKLKVGDVVSISGYIYTGRDAVLPKIVKHAEEGTLSEVGVDLQGQV 59

Query: 419 IYYAGPAKTPAGYPSGSLGPTTAGRMDSYVD-LLQSHGGSMIMLAKGNRSQQVTDACHKH 477
           I++   +          +GPT++ +++        S  G  + L KG    +   A  ++
Sbjct: 60  IFHTAVSPA-------GVGPTSSNKLEIESSFEPLSRHGIKMHLGKGAIKPETVKALAEN 112

Query: 478 GGFYLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFF 535
              +  ++  P   L +   +  E V YPELGMEA+ +I+V  + A I    KG   +
Sbjct: 113 NAVF--AVIPPVTALLESQTEEREVVCYPELGMEALHRIKVNKYQAIIAA-AKGESIY 167


>UniRef50_A5ULQ6 Fumarate hydratase, FumA n=3 Tax=Methanobrevibacter smithii
           RepID=A5ULQ6_METS3
          Length = 163

 Score =  155 bits (391), Expect = 5e-36,   Method: Composition-based stats.
 Identities = 41/175 (23%), Positives = 78/175 (44%), Gaps = 14/175 (8%)

Query: 361 VDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHPIY 420
             +  P+ +   ++S+  +  ++ L+G +  GRD A  +L ELI  G + P       I 
Sbjct: 2   KKIKTPISD--EEISELQIGDKILLSGVMYTGRDAALPQLVELIKKG-KTPINTNGIAIM 58

Query: 421 YAGPAKTPAGYPSGSLGPTTAGRMDSY-VDLLQSHGGSMIMLAKGNRSQQVTDACHKHGG 479
           +   +          + PTT+ + +        S  G  I + KG  + +   A +K+  
Sbjct: 59  HTAVSDA-------GIAPTTSNKEEIESTIPFLSENGVKIHIGKGMLNDETKKALNKNNS 111

Query: 480 FYLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDF 534
            ++  I  P A L   ++   ECVA+   G+EA++K++VE+ P  + +   G   
Sbjct: 112 IFV--ITPPVAALLTNNVLEKECVAFENEGIEALYKLKVENIPGIVAI-AHGKSI 163


>UniRef50_B9Z0L3 Tartrate dehydratase alpha subunit/Fumarate hydratase class I
           N-terminal domain-like protein n=1 Tax=Lutiella
           nitroferrum 2002 RepID=B9Z0L3_9NEIS
          Length = 219

 Score =  148 bits (373), Expect = 7e-34,   Method: Composition-based stats.
 Identities = 36/163 (22%), Positives = 51/163 (31%), Gaps = 12/163 (7%)

Query: 35  DGETILKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEASENDKYVALQFLRNS 94
           D E  ++   + +                P   K   A L   E +   K +      N 
Sbjct: 2   DKEAAVQSLTDVMAKFTAYIGKRL-----PKDVKAKLADLRTMETNPLAKSIYDSMAGNQ 56

Query: 95  EIAAKGVLPTCQDTGTAIIVGKKGQRVWTGGGDEETLSKGVYNTYIEDNLRYSQNAALDM 154
           E A +   P+CQDTG      + G      G  EE L +          LR++     + 
Sbjct: 57  EAADRLNRPSCQDTGVIQYFVEAGANFPLLGELEEILQEATAEATRIGPLRHNAV---ET 113

Query: 155 YKEVNTGTNLP---AQIDLYAVDG-DEYKFLCVAKGGGSANKT 193
           + E NTGTN       +D   V   D         GGG     
Sbjct: 114 FDEKNTGTNTGTNIPWLDWRIVPELDSCTIDVYMAGGGCTLPG 156


>UniRef50_UPI0001C35B8A Fe-S type hydro-lyase tartrate/fumarate beta region n=1
           Tax=Clostridium hathewayi DSM 13479 RepID=UPI0001C35B8A
          Length = 168

 Score =  144 bits (364), Expect = 7e-33,   Method: Composition-based stats.
 Identities = 44/178 (24%), Positives = 76/178 (42%), Gaps = 16/178 (8%)

Query: 361 VDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGK--ELPQYIKDHP 418
           + +N P ++   +         + ++G I  GRD     + EL   G+  E    +    
Sbjct: 2   IKINVPFRDKECR---LKAGDLIEMSGKIYCGRDAVLPYVVELAKKGELSEHGIELDGAV 58

Query: 419 IYYAGPAKTPAGYPSGSLGPTTAGRMDSYVDLL-QSHGGSMIMLAKGNRSQQVTDACHKH 477
           I++   +          + PTT  + +    ++  S  G+M  L KG    +  +   K+
Sbjct: 59  IFHTAVS-------CAGIAPTTTSKPEIEGSMIPLSEKGAMFHLGKGRLLPETIEGLKKN 111

Query: 478 GGFYLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFF 535
           G ++L  I  P + L   S+     V +PE GMEA ++I V+DFPA + V   G   F
Sbjct: 112 GAYFL--ITPPVSALLTASMSECRAVLHPEFGMEAFYEITVKDFPAIVAV-ADGESVF 166


>UniRef50_C8T983 Fumarate hydratase class I n=3 Tax=Enterobacteriaceae
           RepID=C8T983_KLEPR
          Length = 105

 Score =  125 bits (315), Expect = 4e-27,   Method: Composition-based stats.
 Identities = 81/105 (77%), Positives = 96/105 (91%)

Query: 1   MSNKPFIYQAPFPMGKDNTEYYLLTSDYVSVADFDGETILKVEPEALTLLAQQAFHDASF 60
           MS KPF+YQ PFP+  D+TEYYLL+ ++VSVA+FDG+ +LKVEP+ALTLLAQQAFHDA+F
Sbjct: 1   MSTKPFVYQDPFPLAHDDTEYYLLSKEHVSVAEFDGQQVLKVEPQALTLLAQQAFHDAAF 60

Query: 61  MLRPAHQKQVAAILHDPEASENDKYVALQFLRNSEIAAKGVLPTC 105
           MLR +HQ+QV +IL DPEAS+NDKYVALQFLRNSEIAAKGVLPTC
Sbjct: 61  MLRVSHQQQVGSILLDPEASDNDKYVALQFLRNSEIAAKGVLPTC 105


>UniRef50_B5Y8W4 Hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta region
           n=1 Tax=Coprothermobacter proteolyticus DSM 5265
           RepID=B5Y8W4_COPPD
          Length = 154

 Score =  125 bits (314), Expect = 4e-27,   Method: Composition-based stats.
 Identities = 45/164 (27%), Positives = 71/164 (43%), Gaps = 12/164 (7%)

Query: 377 YPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHPIYYAGPA-KTPAGYPSGS 435
                  S  G I + RD     + E    G+ LP       ++ AGP        P GS
Sbjct: 2   LREKQWYSCRGVIGITRDRGLQTICE---EGQHLP-----GVVFLAGPTLMAAKEAPLGS 53

Query: 436 LGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHGGFYLGSIGGPAAVLAQQ 495
            GPT+  RM  +++   +  G  +++AKG  S  V +   + G  Y  ++GG  A    +
Sbjct: 54  CGPTSVSRMLPFLEA-MNRLGVQLVIAKG-VSDGVLETFRRIGLSYGIAVGGAGAFYGTK 111

Query: 496 SIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQIV 539
            IK +    Y  LG E  +  EV+DFP ++ V    + +F+ I 
Sbjct: 112 -IKQVLSRKYESLGAEGFFLAEVQDFPFYVCVGGDVDGYFEPIP 154


>UniRef50_O27187 Fumarate hydratase, class I n=1 Tax=Methanothermobacter
           thermautotrophicus str. Delta H RepID=O27187_METTH
          Length = 134

 Score =  118 bits (297), Expect = 4e-25,   Method: Composition-based stats.
 Identities = 29/141 (20%), Positives = 57/141 (40%), Gaps = 11/141 (7%)

Query: 363 LNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHPIYYA 422
           +   +     ++++  V  R+ + GTI  GRD A  KL + + AG+E P  +    I + 
Sbjct: 2   IRIELPATGDEIAKLSVGDRVLMDGTIYTGRDAALPKLVKALKAGEE-PINVMGAAIMHT 60

Query: 423 GPAKTPAGYPSGSLGPTTAGRMDSYVD-LLQSHGGSMIMLAKGNRSQQVTDACHKHGGFY 481
             +          + PT++ + D        +  G ++ + KG    +   A  + G  +
Sbjct: 61  AVSPA-------GIAPTSSNKEDIEESIPYLASRGVLVHIGKGKLGDETVRALKEAGAVF 113

Query: 482 LGSIGGPAAVLAQQSIKHLEC 502
           +  +  P A L    +K   C
Sbjct: 114 I--VTPPTAALLTSRVKSSRC 132


>UniRef50_A8F6X8 Putative uncharacterized protein n=1 Tax=Thermotoga lettingae TMO
           RepID=A8F6X8_THELT
          Length = 161

 Score =  115 bits (287), Expect = 5e-24,   Method: Composition-based stats.
 Identities = 30/167 (17%), Positives = 65/167 (38%), Gaps = 21/167 (12%)

Query: 374 LSQYPVSTRLSLTGTIIVGRDIAHAKLKELIDAGKELPQYIKDHPIYYAGPAKTPAGYPS 433
           + +   S  +  TG + V    A  ++     A   +P ++    I +        G+ +
Sbjct: 13  IRKLKTSDIVKYTGKLTVLSRQALERIIFYERAEGLIPDFMNGELICFGS---IKEGFLN 69

Query: 434 GSLGPTTAGRMDSYVDLLQS--HGGSMIMLAKGNRSQQVTDACHKHGGFYLGSIGGPAAV 491
                  + R   + DL +     GS+ +++K N +        ++G     ++  P A 
Sbjct: 70  IL-----SAR--DFEDLFEKIFLFGSVGIISKANSANPFY--FKRYGRVMFTAMEKPVA- 119

Query: 492 LAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQI 538
                 K  + +AY +L   A+ ++EVED    + +D +G     ++
Sbjct: 120 ------KSFKILAYSDLKSNAVMEVEVEDLLMRVTIDSRGTTKHVEV 160


>UniRef50_UPI000190C03B fumarase A (fumarate hydratase class I), aerobic isozyme n=1
           Tax=Salmonella enterica subsp. enterica serovar Typhi
           str. 404ty RepID=UPI000190C03B
          Length = 56

 Score = 48.0 bits (113), Expect = 0.001,   Method: Composition-based stats.
 Identities = 30/40 (75%), Positives = 33/40 (82%)

Query: 132 SKGVYNTYIEDNLRYSQNAALDMYKEVNTGTNLPAQIDLY 171
           S+  Y    +DNLRYSQNA LDMYKEVNTG+NLPAQIDLY
Sbjct: 16  SQWAYLNLYQDNLRYSQNAPLDMYKEVNTGSNLPAQIDLY 55


  Database: uniref50.fasta
    Posted date:  Mar 8, 2010 10:38 AM
  Number of letters in database: 1,040,396,356
  Number of sequences in database:  3,077,464
  
Lambda     K      H
   0.313    0.145    0.405 

Lambda     K      H
   0.267   0.0446    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 2,045,451,605
Number of Sequences: 3077464
Number of extensions: 79554607
Number of successful extensions: 245820
Number of sequences better than 1.0e-01: 107
Number of HSP's better than  0.1 without gapping: 214
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 244703
Number of HSP's gapped (non-prelim): 226
length of query: 548
length of database: 1,040,396,356
effective HSP length: 134
effective length of query: 414
effective length of database: 628,016,180
effective search space: 259998698520
effective search space used: 259998698520
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.3 bits)
S2: 96 (41.5 bits)
