>ss_pred
CCCHHHHHEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCCCCCEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCEEECHHHHHHHHCCCCEEEEEEEEEEEEECCCCCCCEEEEEECCCCEEHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCEEEEEEEEEEEECCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHCCCCCCCCCCCCCCCHHHHHHHHHCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCHHHHCCCCCEEEEECCCCCEEEEEHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEECCCEEEEEECCCEEEEEEHHHCCCCCCCCCCCCHHHHCCCCCCCEEEEEEECCCCCCCCEEEEEECCCCEEEEEHHHHCCCCCCCEEEEEECCCCEEEEEEECCCCCEEEEEECCCEEEEEEHHHCCCCCCCCCCEEEEEECCCCEEEEEEECCCCCEEEEEECCCEEEEEEHHHHCCCCCCCCCEEEEEECCCCCCEEEEEEECCCCEEEEEECCCEEEEEEHHHCCCCCCCCCCEEEEEECCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>ss_conf
97404431116799998888988888887620486301388724689999999858888886355257788886023887489999999972123115620045788747898798101146888876999988631162110421278997147616133362010137995301001169898889999999999828999877875205788677541562326688762368728999999999750677862799984798526899999999988728865411000235888569999838887989999988855372254310289999896436099999999999999999988799999999999998519999998789999987178889999989751012210012343210001100000122344444456898899888715245755434999999999999999999988489899999999999999998386744186045210356642446857999818972886435664430246777321233777523799987118759999149909998856676776467671358654778997499999716888874799997799489988776402322655998625997479999739997699993599099986786676577776337786289987999997179975999966990787669870434658723389985278884799998089967999964996999898553524344675289994799879999973577676544456766555532333345657777679
>batch____
MSDLAREITPVNIEEELKSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTEKIPDVMPTKIPNLLVNGSSGIAVGMATNIPPHNLTEVINGCLAYIDDEDISIEGLMEHIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARAEVEVDAKTGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDIIAAFVRHRREVVTRRTIFELRKARDRAHILEALAVALANIDPIIELIRHAPTPAEAKTALVANPWQLGNVAAMLERAGDDAARPEWLEPEFGVRDGLYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKELLDQIAELLRILGSADRLMEVIREELELVREQFGDKRRTEITANSADINLEDLITQEDVVVTLSHQGYVKYQPLSEYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDHILCFSSRGRVYSMKVYQLPEATRGARGRPIVNLLPLEQDERITAILPVTEFEEGVKVFMATANGTVKKTVLTEFNRLRTAGKVAIKLVDGDELIGVDLTSGEDEVMLFSAEGKVVRFKESSVRAMGCNTTGVRGIRLGEGDKVVSLIVPRGDGAILTATQNGYGKRTAVAEYPTKSRATKGVISIKVTERNGLVVGAVQVDDCDQIMMITDAGTLVRTRVSEISIVGRNTQGVILIRTAEDENVVGLQRVAEPVDEEDLDTIDGSAAEGDDEIAPEVDVDDEPEEE
>UniRef50_Q2NJM2(21-835:835) DNA gyrase subunit A n=5 Tax=Candidatus Phytoplasma RepID=Q2NJM2_AYWBP  E=0 s/c=0.87 id=46% cov=92%
------KIQEVNLSEEMKKSFLSYAMSVIVSRALPDIKDGLKPVQRRILYSMKELGVYSHASYKKAARVVGDVMGKYHPHGDSSIYEAMVRMAQDFSYRYPLVDGHGNFGSIDGDKAAAMRYTEVKMAKMAMELIKNIDKETIDFVDNYDGTEKEPLVLPTALPNLLINGATGIAVGMATKIPTHNLGEVIDGLINYINNKDISIDELMQHIKGPDFPTGGELLGLQSLKSAYHTGQGAVILKAKSHVL--EERGKTSIIVTEIPYQVKKTDLIEKIAFLVKNKIVEGITDLRDESSRKGMKIVIELKRDANAKIILNKLYKHSQLRISFGINMVALVGKTPQLVSLKQILEAFFNFRIEVINRQKSFELKKASARKHLVTALITILEDIEIAIKLIKTSTDVKEAQRKLMQK----------------------------------YNFDEIQSKAILEMSLQRLSNQETQKLITEEKNLTQEILECKSIIDSQKKKERILEKELLEMKKKYQDDRKTTLNFD-APLNFedEDLIEKKPIIITITNKGYIKSMDIDTYKQQKRGGQGVSGMKIYEEDFIEHLAITSTHDYHLFFTNKGKVYQLKGYEIPLGQRQSKGSHLVNFLPFEKDEFLTSFTSIKNFDQSQDyLFFATKKGIVKKTPLKEYSHISKRGLIAIRLKENDEVLTVKKTTGIKNIILASNNGNAICFCETKIKSISRNSMGVIGMRLGSDEFLVGaalFDVDSKEQNILVMTENGFGKITNVNQYRIQARSGKGSKTIKVNDQKGRLITLQVVLPSDDLIVSSDKGQVVRVAIDQITKTkNKATQGTRIIKLKTGHKAVSVAVVKKEV--LDIDVVE-----------------------
>UniRef50_C5CCL2(26-806:868) DNA topoisomerase IV subunit A n=41 Tax=Actinobacteria (class) RepID=C5CCL2_MICLC  E=1e-130 s/c=0.60 id=43% cov=83%
-------IVDVDVSEEMEASFLEYAYSVIYSRALPDARDGLKPVQRRILFMMSRMGLRPDRGHVKSARVVGEVMGKLHPHGDAAIYDAMVRLAQPFSLRLPVVDGHGNFGSLD-DGPAAPRYTEARMAPAALALTADLDEGTVDFVPNYDNQFQQPAVLPAAYPNLLVNGTTGIAVGMATNMAPHNLREVVAGARHLLADPEAGLEAIMAHIPGPDLPSGGRIVGLDGVRDAYATGRGT--FRMRAAVAVEQVSARRTgLVVTELPYGVGPEKVIERIKAGVDAKKLSGIADVVDLTDrKNGLRLQIELKSGFNPQAVLAALYRHTPLEETFGINNVALVDGQPQTLGLLPLLRVYVDHRLDVVRRRTGHRLGKHRDRLHLVEGLLLALVDIDEVIEIIRSSDDTAAARTRLM----------------------------------GVFDLTQVQADHILELRLRQLTKFSRIELQAERDELQAAIAELEAILASDARLREVVSAELQAVADEHGDDRRTVLleaetaaapaagpapsgptPAGAAEAGVDLMVPDTACWALLSTSGRL----LRTADRTPIAPQG----RRRKHDAFASVVPTTARGEIGALTSAGALHRLQAVDLPVAGEPSAAPamtaalPAAELVPLAKGETLVALVPLDTV-----MALGTAHGVVKR-VRPEWPLNRQVVD-AVALKDGDAVVGAAPAPDEaDQLVFLTRTGQLLRYAASAVRPQGPAGGGVAGIRLAAGDTVLAFGVapaasltetgadaaahPRPavvvtvtDGeADVLGSAPGSVKVTPLGEYPAKGRGTGGVRAHRLLKgESGLVLG------------------------------------------------------------------------------------------
>UniRef50_D2MM14(18-733:830) DNA topoisomerase IV, A subunit n=2 Tax=Erysipelotrichaceae RepID=D2MM14_9FIRM  E=1e-128 s/c=0.65 id=38% cov=82%
------------LEDIMGAGFGRYAKYIIQERALPDVRDGLKPVQRRILYAMYNDGNTHDKPYRKSAKTVGLVIGNYHPHGDSSVYDAMVRMSQDWKVRMPFIDMHGNNGSIDDDPAAAMRYTEARLAKVTQVMEEDLDKDTVEMSPNFDDTDIEPTVLPVSFPVMLVNGATGIAAGYATNMPPHNINEVIDATIYRIQNAECSLNDVMDILPGPDFPTGGIVQGEEGIREAFTTGKGRIVVRAKTEI-IQEKNLQQ-IVITEIPYEVVKGNLVKKMDEIRISREVDGLIDVRDESDRNGLRIVIDVRKDVDANLILQYFFKNTDLQVYYNYNNVAIMRERPVQVGLLGLLDAFIDFRKEVVLRRSRFELNKMEARVHIIEGLIKAVSVLDEVIAIIRASKDKADAKFRLIEN---------------------------FG-------FDEVQAEAIVTLRLYRLSNTDIVSLRNEFAQLVNQIEETKSILENESVLRHLMVQELRQVKENYGDARRTKIEAKIDEINIskEAMIPSEQVMITVSKDGYLKRVSLRSFNAVRDQETG-----LKTGDQLIGQREVNTLDTLLLFTSKGNYAMVPVWQIDDEKWKEIGSHLNKLVRVDSEEKVISAIVVKNFDSYAWITLVTKGNKIKKTKLSDWKVERTSRLFkAINLEEKDEVCAAFMTYQSQEVLVVTKDGYALRMSQDQIPEVKA-SKGVQAMKVAFEDEVAFATSVYSSDNLLFLTDTLQAKRIHLEDLRLSGRA------------------------------------------------------------------------------------------------------------
>UniRef50_A9F3U1(37-775:800) DNA gyrase subunit A n=3 Tax=Myxococcales RepID=A9F3U1_SORC5   E=1e-114 s/c=0.56 id=39% cov=83%
-----------SLADEAQRRYLNYALSVITSRALPDVRDGLKPVQRRILYAMlHDLHLGPDAKYRKSAAVVGDVMGKYHPHGDVAIYDAMVRLAQDFVMRAPLIAGHGNFGSVDGDAPAAMRYTEAKLRPLALELLSELGQRTVDFRPNYDGTRFEPIVLPSRFPNLLVNGSQGIAVGMATSIPPHNLGEVIDACVALIENRELTTHRLLSYVKGPDFPTGGQLHAtKKELEAVYTAGQGSLKLRGEWQLEEgDGKRGaAPQIVITSIPYGIERKAIVEKIAEVILSKKLPTLVDVRDESTGE-VRIVMELKRGADAQLVMAYLYKQTPLAINVQVNLTCLvptdnaEIAAPRRLGLHEILTKFLDFRYATVTRRLEFELGELRRRITILEGFEKIFDALDEVIRIIRKSEGKADAAEKLMKR----------------------------------FTLNEEQTDAILELKLYRLARLE---ILLVQKDLGEKRAEAKRIEGllrSDAKRWGIVRDELVEIKGSYGEKRRTKVvgSIDEPEYQAEDFIVAEDANVILSAQGWVK---------RVREVKDLASTRIREGDSVLAAVAGSTRSTVAFFSNLGACYVCRIHDVPQST--GYGDPVQKLFKLADGERLIALMSFD--PRALDVPAQTPDSA-----------------------EPEPPFALAITRG----------GLGFRFSLRPHRDPSTR-SGRRFAKLNEGDEVLFVHAVDGADRVLCASSDAWALSVAVEELALLSGPGKGSVVMRVAEGERLVGAALALGPSDVITVETEKGKTLEIAASKIA-GQRGTQG------------------------------------------------------
>UniRef50_Q8I0X3(171-1107:1222) DNA gyrase subunit A;evidence=inferred from direct assay n=9 Tax=Plasmodium RepID=Q8I0X3_PLAF7  E=6e-70 s/c=0.29 id=33% cov=82%
---------DVEICEILSKSFLSYANFLILNRCLCDYRDGLKTVQRRIIWSMYEINKGIDkKGYKKCARIVGEVIGKYHPHGDKSVYDALVRLAQKHHNNNLLIKGYGNFGSVEYN-AAAMRYTEAKISSFCYDILLDeINDENVEYIKNFDGNEREPKVLCSKIPLLLINGCSGIAVSILSSIPCHNLIDVANCCINFLINENIRDDELFHIIKGPDFSTGGIIISKYDIlKNIYNSGKGNFEIRSNVFFEYikndkkvitkhindlssiensDIDKLTKKIIIKNLPPNVKPNELIENIINLLNDKKNEHDNILlriRDESEKEDMRIVLELKKHSQIEQIhnfLSYLFKYTNMQISYHCNFVCIgYENTYTQFSLKSFIKLWCNNRIKFI--KTNYEI-KNKNLQKQLNIIDLYLIIQNKILDII------------------------TFFQKNQNIEQIQLYLKNNFK-------LNPEQIKYILSIKLQKLINIKNIDFISQRNKIMHQIKLNDEIINNVQNIKNLIIQELIYIKNKYGihnlnkqciipstpkykysyinseyhpnfsknkqiidtyntvstndnninhsnythdlpntdnvtkDKnvvetnvhknihissdisnniknsdKNSSLTKNqdsdnmmpyrntyidSLDNNMKDIYNNDEVLILITYGGYIKKIKINEKLKNHSNNiiklsnvkyilkeneeklnennkrlkfndlqKGNEQEKYKdneqklnndighniniqnnnndnnnnnndnnnvlllnEEEYnsykIKKSILVRNRDKILLTDNYNKAFLLNVYDLHLSSYDSKGTPINQI--IHSSKNITGI---TKFQENKKYLIVCSeNGKMKVINNDVFLKRKKKG---IKLFKNKKNIYFSYCNFNDNCIVGTKNGYIIQFPLSSFKISKKNSLGNKCISLAKNDKVVDLLSYENneknlkNYKIIFVTKNGFGKMINLNELKIQKKKGKG---------------------------------------------------------------------------------------------------------
>UniRef50_P57277(1-826:830) DNA gyrase subunit A n=76 Tax=Proteobacteria RepID=GYRA_BUCAI   E=0 s/c=1.51 id=67% cov=95%
MKDPSREIIQVNIEEELKSSYLDYSMSVIVGRALPDVRDGLKPVHRRILFAMYILNNDWNKAYKKSARIVGDVIGKYHPHGDSAVYDAIVRMAQKFSLRYMLIDGQGNFGSVDGDSAAAMRYTEVRMSKIAHELLNDLEKNTVEFLPNYDGTEYIPEILPAKIPNLLINGSSGIAVGMATNIPPHNLNEVINGCLAYIDNNDITLEELIKHIPGPDFPTAAIINGKSGIEEAYRTGKGKIYIRAQNQIEKNKKNKKESIVFNEIPYQVNKSRLIEKIAELVKEKRIDGITALRDESDKDGMRIVIEIKREAIAEVILNQLYSLTQLQISFGINMVALCQGQPKTLSLKEILKNFLSHRQEIIIRRSLFELNKVRNRIHILEGLNMALININAIIEIIKNSVNSIDAKKIIIQKNWKSEKINYLAKK-------------------HEYYFSEKQAQAILDLRLHKITNLEQEKIIMEHNDLIKKTKELKEILENPKKMFEVIKSELLSIQNNFSDKRRTKITENHSDINMEDLINQEDVVVTLSHSGYVKYQPLSDYNAQRRGGKGKSAAKIKEEDFIESLVIANTHDTILCFSSRGILYWMKVYQLPESSRHARGRPIVNLLPLSPKERITAILPVHKYQDNLNIFMTTAHGIVKKSSLSQFKKPRFAGIIAINLHANDELIGVALTDGNNNIMLFTQNGKVVQFLENSVRTMGRTASGVKGIKIKKNDKVVSLIVPKNKGSILIATKNGYGKRTKISDFPIKSRATQGVISIKITKKNGKIIGAIQVIEKDQIMMITDAGTLVRIRVSEVGVLKRNTQGVILIRTSKNEKVVALQKIVDPMIE------------------------------
>UniRef50_C8WIN1(91-932:932) DNA gyrase, A subunit n=39 Tax=Bacteria RepID=C8WIN1_EGGLE   E=0 s/c=1.47 id=50% cov=94%
------------LGKEMQTSFLEYAMSVIVSRALPDVRDGLKPVHRRILYAMNESGYTPNRPHMKSARTVGDVIGKYHPHGDSAVYDTMVRLAQPFSMRVPLVDGHGNFGSIDGDGAAAMRYTESRLDKVAMELLRDLDKETVDFQPNYDESLEEPTVLPARFPNLLVNGSQGIAVGMATNIPPHNLGETIDATCLMLDNPDVTTEELMKALPGPDFPTGGIIMGKKGIRDAYETGRGSLTVRAKCKVE-EGKNGRSSIVVTEIPYQVNRQRLLEKLGELVREKKLPEISNIHDGADRHGIDIIIDLKKDAIPQVVLNKLYKHTQLQVGFGVIMLSLVDGAPRVLSLKEMLHYYIAHQEEVIVRRTRYELAKAEERAHILEGLIIALDNIDEVIHIIRSSQTDKEAAERMTER----------------------------------FGLTDKQTAAILEMRLRRLTGLEHQKIEDELKELLEKIAYFKRVLSDDQLVHDIIKEELSEVKKKFGSPRRTLLSEAAKDLDVEDLIAEESMVVTMTKAGYVKRLPVATYRQQKRGGKGMSGVNLKDNDYVEHLFVASTHSYMLFFSTKGKVYRLKVYELPEASRHARGTAIVNLLPLEKGETISAVIATKDFPSDEYLMFATEHGMVKKTSMDLYDRTRRDGLIAISLKDNDRLISVKRVAPGEKVLMVSSAGKAIMWDEGEVRAMGRDTMGVRGMNVPPIAKVLGMEIAQPDTDLFVITEKGYGKRTPIAEYPEHHRGGQGVFTITMTEKKGLLAVMKIVAEDDEIMIMSEEGVCVRTPVSGISELGRSTQGVCVMKTADKDRVTAVAissrgkkkkasgaqVEGEELDENAIDELEDGAEGTAEiesvEEAENAEGDEE----
>UniRef50_Q8DPM2(1-821:822) DNA gyrase subunit A n=213 Tax=Bacteria RepID=GYRA_STRR6   E=0 s/c=1.50 id=50% cov=94%
MQD--KNLVNVNLTKEMKASFIDYAMSVIVARALPDVRDGLKPVHRRILYGMNELGVTPDKPHKKSARITGDVMGKYHPHGDSSIYEAMVRMAQWWSYRYMLVDGHGNFGSMDGDSAAAQRYTEARMSKIALEMLRDINKNTVDFVDNYDANEREPLVLPARFPNLLVNGATGIAVGMATNIPPHNLGETIDAVKLVMDNPEVTTKDLMEVLPGPDFPTGALVMGKSGIHKAYETGKGSIVLRSRTEIET-TKTGRERIVVTEFPYMVNKTKVHEHIVRLVQEKRIEGITAVRDESNREGVRFVIEVKRDASANVILNNLFKMTQMQTNFGFNMLAIQNGIPKILSLRQILDAYIEHQKEVVVRRTRFDKEKAEARAHILEGLLIALDHIDEVIRIIRASETDAEAQAELMSK----------------------------------FKLSERQSQAILDMRLRRLTGLERDKIQSEYDDLLALIADLADILAKPERVSQIIKDELDEVKRKFSDKRRTELmVGQVLSLEDEDLIEESDVLITLSNRGYIKRLDQDEFTAQKRGGRGVQGTGVKDDDFVRELVSTSTHDHLLFFTNKGRVYRLKGYEIPEYGRTAKGLPVVNLLKLDEDESIQTVINVeSDRSDDAYLFFTTRHGIVKRTSVKEFANIRQNGLKALNLKDEDELINVLLAEGDMDIIIGTKFGYAVRFNQSAVRGMSRIATGVKGVNLREGDTVVGASLITDQDEVLIITEKGYGKRTVATEYPTKGRGGKGMQTAKITEKNGLLAGLMTVQGDEDLMIITDTGVMIRTNLANISQTGRATMGVKVMRLDQDAQIVTFTTVAVAEKEEVGTENETEGE-------------------
>UniRef50_B2RJ49(1-851:859) DNA gyrase A subunit n=17 Tax=Bacteria RepID=B2RJ49_PORG3   E=0 s/c=1.42 id=48% cov=95%
MTDREDRIINISIEEEMKTAYIDYSMSVIVSRALPDVRDGFKPVHRRVLYAMNETGNVYTNPTRKCANAVGEVLGHYHPHGDSSVYMALVRMAQPWSLRYPLVDGQGNFGSVDGDSPAAMRYTESRLSRIAGEMLQDIDKETVDFQNNFDDTRQEPTVLPTRIPNLLINGASGIAVGMATNMPPHNLSEAIDGCVAYIEaDGDIDVEGLMQYVKAPDFPTGGFIYGYSGVKEAFETGRGRVVIRSRAEIE--QHNNHERIIITEIPYLVNKAELVSNIAQLINEKRLDGISNISDESNRKGMRIVVEIKRDANASVVLNKLYKMTALQSSFSVNNIALVKGRPRLLNLKDLIGEFVDHRQEVVTRRCRFELRKARERAHILEGLLIAVDNIDEVISIIRSSKDAAEAMSRLIER----------------------------------FDLSDIQARSIVDMRLRALTGLERDKLRAEFEEIMASINHLEALLADRALLMELVKSELLEIKEKYGDTRKSEIIYASEEFNPEDFYADDDMIITLSHMGYIKRTPLSEFRTQARGGVGAKGSDTREEDFVEYIYSASMHATIMLFTAKGRCYWLKVYEIPEGAKNAKGRAIQNLLNIDPDDKVNAFIRIknlttdKEFVNSHYLLFCTKRGIIKKTLLEAFSRPRANGVIAIDLRDNDGLVSVRLTNGKCDMVIANRGGRAIRFHESVVRPSGRTAMGVKGMTLDDDgeDEVVGMISIKhpEEETILVVSEKGYGKRSNIDDYRITNRGGKGVKTLNITEKTGKLVDIRAVTDANDLMIINKSGVAIRVKVADLSIIGRATQGVKLIDLSKrGDEIASVCSVVSEEEENKAEkhadhTHEVLPQDDSSSSVENGDVSD-----
>UniRef50_Q1RID9(1-884:905) DNA gyrase subunit A n=218 Tax=Bacteria RepID=GYRA_RICBR   E=0 s/c=1.37 id=53% cov=95%
MTDnNSSNLVPVNIEDEMKVSYLDYAMSVIVSRAIPDVRDGLKPVHRRIIYSMHEAGNHANRAYRKSARIVGDVMGKYHPHGDSAIYDSLVRMAQDFSLRLPLVDGQGNFGSLDGDAAAAMRYTESRMAKVAHKLIEDIDKETVSFNPNYDGSEEEPSVLPSMFPNLLVNGSGGIAVGMATNIPPHNLGEVIDACCLYVDNNDIEILDLLEVVKGPDFPTSGIILGVNGIKSAYLTGRGSIAIRGRAEIE-NLGNGRQAIIITEIPYMVNKARLVEKIAEMVKEKRIEGISDLRDESNKNGIRIYIELKKDIVAEVVLNQIYSCTQLQTSFGVIMLALKDGLPKVMNLKEVIAAFVSFREVVITNRTIYLLNKARDKAHILLGLTIAVSNIDEIIRIIKAASDPNAAKQELMARSWDALNILPLVKLVDDKAMLNE---------EGKCSFTEAQAKAILEMRLQRLTAMEKNKLEEDLKNLATEITEYLNILGSRERLLEILKEELIKVKEEFATPRLTSIEFGEFDQDIEDLIQREEMVVTVTLGGYIKRVPLSSYRAQKRGGKGRSGLSMRDEDITTQVFVGSTHTPMLFFSNIGQVYSLKLYKLPLSNPQGKGRPMVNILPLKGDEHITNIMPLPENQdewDNLNIMFATAKGNIRRSDLLDFKKIQSNGKIAIRLDEDDKLIDVKPCKEDEHILLATKSGKALRFPVESLRVIKsRTSDGVRGMRLAEDDSVISMTVLKGikatreerdaylsvswekrleiakgeefnseelgvdltaesilemansEEFILTVTENGFGKRSSAYGYRITDRGGSGIINMDINDKTGLVVGVMPVKMDDELMLITNSGKLIRCKLETVRITGRNTSGVTLFRLDDGEKVVSASLIAE----------------------------------
>UniRef50_Q55738(1-860:860) DNA gyrase subunit A n=43 Tax=cellular organisms RepID=GYRA_SYNY3   E=0 s/c=1.40 id=47% cov=94%
MTDSPDRLIATDLRNEMSQSYLEYAMSVIVGRALPDARDGLKPVHRRILYAMYELGLTPDRPFRKCARVVGEVLGKYHPHGDTAVYDALVRMAQDFSMREPLIDGHGNFGSVDNDPPAAMRYTESRLRPLStNSLLRDIEAETVDFIDNFDGSQQEPTVLPARIPQLLINGSSGIAVGMATNIPPHNLGEVIDGAIALIRNPEITEQELMQIIPGPDFPTGAQILGRSGIREAYLTGRGSITMRGVASIETMEHPGrpdRDAIIVTELPYQTNKAALIERIADLVNDKKIDGIADIRDESDRDGMRIVIELKRDAYARVVLNNLYKQTPIQSNFGANLLALVNGTPEVLTIKKFLTVFWEFRIETITRRTRYELRKAEERDHLLQGLLIALDNLDAVIRLIRGAADTASAKTELVE----------------------------------GFSLSEVQADAILQMQLRRLTALEADKITAEHDELQTKIADFQDILARRERVNAIIEEELEQIKAIHATPRRTVIVQEDGELIDTDLIANDQALILLTEQGYIKRMPASTFGTQNRATRGKAAAKIKDDDGVEHFLSCCDHDKVLFFSDRGVVYSLNAYQIPIASRTARGVPIVQMLPIPKDEKITSLVSVSEFDDDTYFIMLTKQGYIKKTALSAFSNIRANGLIAISLVEGDQLRWVRLAKAEDSVIIGSQKGMAIHFkaDQDELRALGRATRGVKSMRLRSGDALISMDILpsqvvaniavgsedepdedlggdtdaileesdNPGPWLLGVTMKGFGKRVPIGQFRLQHRAGLGVKAIRFKSKDDQLVALHVVNADDELMIVTNRGIIIRQSVNDISPQSRSATGVRVQRLDADDAIAAVALVPPSGEEELAEMSESEES-------------------
>UniRef50_C6X523(1-814:884) DNA gyrase subunit A n=20 Tax=Bacteria RepID=C6X523_FLAB3   E=0 s/c=1.48 id=50% cov=92%
MQKEGERLIPINIVDEMKSSYIDYSMSVIVSRALPDVRDGLKPVHRRVLYGMYGLNVFSNRKHLKSARIVGDVLGKYHPHGDSSVYDAMVRMAQPWSLRYPQVDGQGNFGSMDGDPPAAMRYTEAKLKKISDEILADLDKDTVDFQNNFDDSMTEPTVMPTKIPTLLVNGTSGIAVGMATNMAPHNLSESIDAIVAYIDNKEITIDELMKHIIAPDFPTGGIIYGYDGVRDAFHTGRGRIVLRAKINFEE--VGNRSAIIVTEIPYQVNKAEMIARTAELVKDEKIPGIYEIRDESDRQGLRIVYELKHDAIPNVVLNMLYKYTSLQTSFSVNNIALVKGRPEQLNLKNIIHHFVDHRHEVVIRRTEFELKKAKERAHILEGFMKVIgtqDDLDKAIAIIRHSSNPAEAKDGLMKE----------------------------------FDLSDLQAQAILDLRLARLTGMELDKIRAEYDEIMNLIRDFEDILANESRRFEIIKAELIEMKEKYGDERRSEIDYSGGEMSIEDLIPDEKVVLTISHAGYIKRTSLSEYKVQTRGGVGNRAATTRDEDFLEYIVAATNHQYMLFFTEKGKCFWLRVFEIPEGSKISKGRAVQNLINIEPDDKIKAYIRTNDLKDAEYInqmnvVMVTKNGTIKKTSLEAYSRPRTNGVNAIEIRDNDQLLGARLTSGDSEIMIATKNGKCIRFPEEKARAVGRGSIGVRGISLEDDDEVIGMIVVNDveNETVLVVSEKGYGKRTAVEDYRVTNRGGKGVITLNITEKTGNLIAIQNVTDEDGLMIINKSGVAIRMSMNEMRVMGRNTQGVKVINLKGNDSIAAIAKV------------------------------------
>UniRef50_C7H1V9(13-837:854) DNA gyrase, A subunit n=3 Tax=Clostridiales RepID=C7H1V9_9FIRM   E=0 s/c=1.43 id=48% cov=94%
----TKKIIR-DVKKEIETAFLDYSMSVIVSRALPDVRDGLKPVHRRILYTMHERGNDPSHAYRKSADTVGAVLGSYHPHGDASVYDAMVRLAQDFSLRYPLVDGQGNFGSVDGDPPAAYRYTEARMSRMAVEMLTDIDKDTIDWDPNFDETKKEPSVLPCRFPNLLVNGSQGIAVGMATNIPPHNLSEVIDGCVAYIEDPDIDLPGLMEHIKGPDFPTAGIIMGRSGIRAAYATGRGKITLRGRATIE-EKKNGRAQIIVTEIPYMVNKARLIENIADLVKEKRIEGISDLNDETNRKGMRIVIDVRKDANPQVVLNQLYQYTQLQDTVGVIMLAIDHKVPKVMTLKQMIQKYVEFQDEVVRRRTQYDLKKARERAHILEGLKKATDIVDELIATIRACKGGmSEAKAAIMEQ----------------------------------FGFDDPQADAIVKLQLGRLAGLEILKIEEELGSLNAKIRDWEEILADDARVLEIVKSELLEMKRRFGDDRRTEIETVTGEVDIEDLIAEEQCVYTLTEAGYIKRQLKATYQAQKRGGRGISGMTRKEEDIVQEMFVGSTHDYVLFVTDKGRLFRIKGYTIAEGSRTSKGTNIVNLLQLAEGEKVTNMLCQSKDtaNEGGFVTMVTKQGLIKRTPLEQYANIRKSGLIGIALNEGDALAWTRLTSGHDMLIVATRNGQAIRFNEEDARPMGRSGHGVRAIKLAEGDEVVGVCICRENATILTVTENGKGRRSDIDTYRITARGGKGIRNYDASK--DKVAAVKIVDDVDDVLLSSQEGIIIRLHANEIPVQSRYGSGVRVMRLGENDKVMVLARTDHD-DEAQTETVE--AEEGDEPTAEQLA--------
>UniRef50_B9ZEE7(28-861:861) DNA gyrase, A subunit n=1 Tax=Natrialba magadii ATCC 43099 RepID=B9ZEE7_NATMA  E=0 s/c=1.37 id=50% cov=95%
----ARAVENVRIEDEMEQSYIDYAMSVIAGRALPDVRDGLKPVHRRILYAMHEMGVTSRSSHRKSSSIVGETMGDYHPHGDSAIYDTLVRMAQDFSMRYPLVDGQGNFGSMDGDPAAAPRYTEARMAAVSEELLEDIDKDTVDFSSNYDDRLQEPDVLPSAFPNLLVNGSSGIAVGMSTNIPPHNLGEVIDATIELIDDPDATVEDLMEHVKGPDFPTGANIVGRDAIYSAYKTGRGRIRVRAEFEVE-EWKNGRERIVITELPYQENKARLVERIAEDVNEGDIEGISDLRDESDRDGVRIVVECKRGANVEVVKNKLLEN-HLEKTFGVINLALVDGQPQVLSLKETLEEYIAHRREVVRRRSEYDLAEAEDRAHILEGRLKAVENAEDVVDLIRNSETRDDAKAALQE----------------------------------AYDFSAEQATHIVRMQLGSLTSMEAAEIEDEYEDVQAEIERLTSILESEQELLAVIKDELSEIKDEYDDDRRTSIIEDQGTVTHEDLIPEEEVFVVMTEDDYVKRMPISQFDPQGRGGKGIIGADVKEDDRVATVFRANTHDYLLCFTNQGKVYQLKTYEIPEMGRTARGKSAVNILDLDPGEDITAIVDTDAFGDDEFVTMATRHGYVKRTAGSEFDNIRSTGIIAADLQEGDELVDVEVTDGTKDLVIASENGMTIRFDEDEVRAMGRNARGVNGIDLQGDDAVAGLVATDEGDeqDLLTVTQNGYGKRTPLSEYRTQSRYGKGLIDIKTGERNGPVTTAKAVSADDQLVMMSERGQIVRTRVDEISTVGRNTMGVIVMDVDDGDAVASVDVVPAAVSEADDDGEDEDEDEGQNEDTETVEADAAN---
>UniRef50_C0R046(21-834:834) DNA gyrase subunit A n=2 Tax=Brachyspira RepID=C0R046_BRAHW   E=0 s/c=1.41 id=45% cov=93%
-KDILKRVDHISIENELRESYLTYAMSVIVSRALPDVRDGLKPVHRRILYAMYDANLTHDKPYKKSAATVGEVLARYHPHGDAAVYGTMVRMAQDFSMRYLLVDGQGNFGSIDDDPPAAMRYTEARMTRFAEEMLNDIEKETVKFVPNFDDSRTEPSVLPATVPQLLVNGSMGIAIGMATNMPPHNLKEVVNAIVYYIDHQDAEIKDLMRYVQGPDFPTAGIIYGKEGIKEAYTTGKGRIKLRARLEVE-ETKRDREAIVVKELPYGVVKTTLHEKIADLVKQGKIEGVADIRDEsSNRAGIRLIIELKKGVATQIVLNQLWKHTDLETTFGIINLALVNGEPKVLNLKELIKYFVDHRVEVITKRTEYDLNQAKAKAHILEGLLIAQANIEEVIRIIRESENTDAARTTLMNR----------------------------------FKLSEKQAQAILDMPLKRLTALEKLKIEQELQQLREFIAYCEDLLAHPEKILAVIKDELKKISEKYGDDRRSEIIGktNDTEIDEEDLIHDEDVAVSITTQGFIKRVPASSYRTQGRGGVGVQGGKSQGEHYIEHLFVASTKDYLFIFTDRGKAFWMKVHEIPALSKISQGKSIKFILNLAPEEKITSYFTVSEFDPKQSIIMVTKMGTIKKMELKHLENAKKRGILALTLENNDELVAVSPVQTGDDFIMTTAAGLALRITEEKIRKMGRAAAGVKGISLDDDDICVSGNAIHKGESLIVITENGIGKRLSSKQFNVKGRGGKGQIYIKPDNKTGNVVSVKTVGDKDEIMVVTTDDMTIKIKADSIPELGRNAKGVKIVNISDGARVSDLAVVPADNEE------------------------------
>UniRef50_P35810(15-876:903) DNA gyrase subunit A n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=GYRA_FIBSS  E=0 s/c=1.32 id=49% cov=93%
------------VEQDMQDCYLRYSMSVIVARALPDARDGFKPVHRRVMYSMHKLGVVPNKGTVKSARIVGDVIGKYHPHGDVAVYDTLARMAQDFSLRYPLVFGQGNFGSIDGDSPAAMRYTEAKMNNLGALMLEDLEKETVDMGPNYDESLEEPLVLPSALPNMIVNGTSGIAVGMATNMAPHNLREVGAAIHALAENPDLTGEDLMEYVKGPDFPTGAIVCGRSGIREAYLTGHGRVRVRARTEIETDAK-GKPRIIVTEIPYMVNKAELCKKIADLVRDKRIDGITDIRDESSRD-IRIVIELRRDAVGEVVLNNLFKYTQLQTTFSIYNLALVNNLPKLLTLKDLLQVYIDHRLDVITRATQFDLKKAAARLHIIEGLRIATQNIDEVVKIIRQSKTTEIAKQSLQDR----------------------------------FSLDEIQSQAIVDMRLAQLVGLNIEKLEAEYNELIATVADLKDILEKRERRVAIMLQKLDAVVDKYGDERRTTIGEAIDDSDDEDLIAEEEQVITLSKEGYIRRLPIDTFKAQNRGGKGIIGAGLKDEDNVEQIFTASTHSYLLVFTNKGRVYWTKVYRLPEGARNGKGRPIVNFVALTEGEKVQAIVPVRKFGGYFCLVFATKKGIINKMDLTLFSRPRKAGVNAISLDEDDELVKVQLVGmsaeeyeasknasdddsaeavenaaeaqaaeaaiaeesesgdaedfanrpiPKDLLMIATKNGQAVTFPISCFRAMGRGTHGVKGITLAEGDEVISLLWLKAGNKILTITEKGYGKRSEPGSYRVTRRGSKGVRNLNVTDKIGAAVFVESVADDYDLIITSKDGQVIRIKAADIRLTGRNAQGVKAITLRDGDVVKDATALPSV---EDIEQDSADAKETFDKV-------------
>UniRef50_B0S912(34-839:843) DNA gyrase subunit A n=6 Tax=Leptospira RepID=B0S912_LEPBA   E=0 s/c=1.41 id=48% cov=91%
------RVIPVEIEDQMKEAYLDYAMSVIVGRALPDVRDGLKPVHRRVLHAMNERAWRSDRPYVKSAKIVGEVIGNYHPHGDSAVYETMVRMAQTFSMRETLIDGQGNFGSVDGDNAAAYRYTEARLTKLAEELLKDIEKNTVSFSPNFDDTRQQPDVLPANFPNILVNGSTGIAVGMATNIPPHNLKEAVNAVIALIQNPDITLPELMKILPGPDFPTGGTIIGGEGLYQAYATGKGSIRIRSKVDI-IENNKGREIIVIHEIPYQVNKKNMLEKIGDLVNEKIIEGISEILDLSDRKGIRVEIHVKKDANAQVILNQLFKLTQLQVSYGITMLAILDNRPKIFSLKEILKSYAEHRREVVVKRTEFDLDKAQKRAHILEGLRIALENIDEVIRIIRASKDVREAQSSLMAT----------------------------------FSLSELQADAILEMRLQRLTSLEVQKIIDELEQVRILIADLEDILSKPDRVKSIICDELGKVSQSFGNTRTTEISLESLEsstFNAEDLIADEEVVVQLSEDMFIKRLPMDTFRRQKRGGKGVQGISTKREDFVKKLSSAMTHDNLMLFSNKGRAFLLKVYELPIATKEARGKSLKAVINLNDDEIITSLFTFRNFDES-YLLMVTREGFVKKIQLDEFTNTKKSGIIAIGLRDGDELIDVIANPNNYDVFIGSKNGLAIRMNLNELRSQGRTASGVTAMKLEDDDSIAGITKVEPNTNLFCISENGFGKRTDFEEFSTKGRGGKGMTYLKIGEKNGRAVGISSVKEEDELLVITQSGMAIRVEVKTISMVGRSAMGVKVVNTKDEDFVKDFAVVRE----------------------------------
>UniRef50_C9M5P0(6-822:836) DNA gyrase, A subunit n=1 Tax=Jonquetella anthropi E3_33 E1 RepID=C9M5P0_9BACT  E=0 s/c=1.39 id=45% cov=92%
------------LVEEIKHSYLDYAMSVIVGRALPDARDGLKPVQRRILYAMMGLGIKHNQPYKKSARVVGETMGKYHPHGDSAIYETMVRLAQEWSMRYPLVDGQGNFGSIDGDSAAAMRYTEARFAETGELMLADIDEDTVDWGPNFDESLKEPLTLPSALPNLLINGSTGIAVGMATNMAPHNLGEVVDALRLLIRRPDAELDDLMSCLPGPDFPTGGIIMGREGILDAYRTGRGKIILRGKCHVEQKSRS-KTNVVITEIPYMINKTTLIESIVKGVQGKQIDGVSDIRDESDRKGLRLVVELTREADAELVQRQLYSRTSLQSTFGIINLALVDNKPVELNLKQLLETFLNYRRSVVRRRTQFRLDKAEARRHIVEGLCKALDVIDQVIAIIRGAQTADDAKAGLI----------------------------------GELAFTDLQAQAILDMRLQRLTGLEREKLLAELAQLLADIERYRSILDNPSVLDGVINDELGELRRKFADERRTELSAAlpTEGDSLEDLLPEEDILVTLSKDGFLRRSPLENYNLQNRGGKGRLGAVLKDDDEVGQMAVTSTHSDIFLFTSRGRVFAIRGHMIPE-TKTGKGRAVSKFVSLTDDERVVAMRGTLEETATSHLLFITKRGIGKRMDAEELENLTRAGRRVLSLDDGDEIAAIIDTDGNSKVLLVTSKAKAAHVDESEFRPMGRAARGVKAMKLAPDDRIIAAWTVAPDENLLLVSETGIGKRTKPEEFPIHHRGSGGVQAMHLGARTGRLAAAVGVASSDEVGLMTEKGRMIRLSASDIPLLSRTATGSIVLRLNDGDLLASVSVIPAPMAPESLTDADP----------------------
>UniRef50_C6HYH3(15-835:854) DNA gyrase, A subunit n=1 Tax=Leptospirillum ferrodiazotrophum RepID=C6HYH3_9BACT  E=0 s/c=1.38 id=49% cov=93%
----------VSIDEEIRTAYLNYSMSVIVGRALPDARDGLKPVQRRVLFAMHEMGVRPGTAYRKSARIVGDVIGKYHPHGDTAVYDTAVRLVQPFTLRYPLIDGQGNFGSVDGDAPAAMRYTEIRLTRLAEEMMAELDEETVDWSPNYDESLEEPRVLPASLPLLLLNGSSGIAVGMATNIPPHNITEVLNALLHLMDNPEATDSDLMTFVTGPDFPTGGVILGRSGIESAYRTGRGSIVMRGVVEVEDSTRSDRQCLVIREIPYLVNKARLIEKIAELVREKKIEHIADIRDESDRDGMRIVVELKREAIPRIIMNQLFLLTPLQSSFGYNAVSIVNGRPETLSLSQTLRVFLGFRKDVVTRRTLFRLRKARERFHILEGLRRAIDLIDEIIALIRRSGSPEEARNGLVST----------------------------------FAFSELQAQAILDLRLQRLTGLEREKIEAEYREVAALIASLEAILASREALLEVIRQETRVLLERFGDGRRTVIVPDEGELTPEALIPDEPYIVTLSYEGYIKRMPDAVLPTQRRGGKGRIGVTLKEDDCLIATLNARAHDTLLFFTDLGKVYRLKTYELPEAQRTARGKHLLSLLSLSPDERVAAILPVRSFEGDNLLLFGTVKGYFKKTRLSEYANIRQGGLIATVLEEGDRLARVLVLHPDRRLLVATRGGMSIRFEADNIRPTGRATRGVRAIRLSPDDSVVSFEEVSDSDLLLVTTEKGFGKRVDTNLFRLQKRGGKGVRIAKVTPETGAVVAILKVTERDDIDVVTDTGRVIRIPSEEIRKVGRGAKGVKLVSLSDspQETIVCAAINPkrEPTPLEAYLEKEPTGRESRGE--------------
>UniRef50_P22446(20-837:839) DNA gyrase subunit A n=3 Tax=Mycoplasma RepID=GYRA_MYCPN   E=0 s/c=1.37 id=46% cov=93%
-------IKNISLSSELERSFMEYAMSVIVARALPDARDGLKPVHRRVLYGAYTGGMHHDRPFKKSARIVGDVMSKFHPHGDMAIYDTMSRMAQDFSLRYLLIDGHGNFGSIDGDRPAAQRYTEARLSKLAGELLRDIDKDTVDFVANYDGEEQEPTVLPAAFPNLLANGSSGIAVGMSTSIPSHNLSELIQGLILLIDNPDCTINDLLGVIKGPDFPTGANIIYTKGIESYFETGKGNVVIRSKVSIEQLPT--RAALVVTEIPYMVNKTSLIEKIVELVKAEEITGIADIRDESSREGIRLVIEVKRDTVPEVLLNQLFKSTRLQVRFPVNMLALVKGAPKLLNMKQALTVYLEHQLDVLIRKTQFNLKKYQERFHILSGLLIAALNIDEVIAIIKKSANNQVAMEALHER----------------------------------FGLDEIQARAVLDMRLRSLSVLEVNKLQTEQQELKALIEFCQQVLADKQLQLKLIKEQLTKINEQFGDPRRSEILYGiSEDIDDEDLITQENVVITMSTNGYLKRIGVDAYNLQHRGGVGVKGLTTYTDDSISQLLVCSTHSDLLFFTDKGKVYRIRAHQIPPGFRTNKGIPAVNLIKIDKDEKICALISVNDYQNG-YFFFCTKNGTIKRTSLSEFANILSIGKRAILFKENDVLFSVIRTSGQDDIFIGSTAGFVVRFHEDTVRPLSRAAMGVLGINLNQCEFVNGLSTSSNGSLLLSVGQNGIGKLTSIDKYRLTKRNAKGVKTLRVTAKTGPVVTTTTVFGNEDLLMISSAGKIVRISLEQLSEQRKNTSGVKLIKLKEKER---LETVTIFKKEEAIKTT--TATETDD---------------
>UniRef50_D2QWS9(20-914:938) DNA gyrase, A subunit n=5 Tax=Planctomycetaceae RepID=D2QWS9_9PLAN   E=0 s/c=1.25 id=48% cov=95%
------------IEDELKESYLTYAMSVIVSRALPDVRDGLKPSQRRILVAMNDLNLTPGAPRVKCAKISGDTSGNYHPHGESVIYPTLVRMAQEWNMRHILIDKQGNFGSIAGLPPAAMRYTEARLSPVASMMLEDLNLDTVDFVPTYDERNQEPTVLPCRFPNLLVNGAQGIAVGMATSIPPHNLGEVCEALVKVIDDPEVTLGELCEIIKGPDFPTGGTICGRAGIRRGYRDGRSTIVLRAKTRIE-EHKKDRYRIIITEIPYQQARDRVVEKIAELVNEERIKGISGITDLSDlKEPVHLVIDIKRDADPYVVLNQLYQFSPLQDSISIILLALVDGKPRELSLKELLEEFLRHRVTVIRRRTQFLLSKARRRKHTVEGLLLALANIDEIIRIIRASRTQAEAKVGLMGVECPAAMMQRALGEEGFAMFQSE------RGASDTYRLTAVQSEAILRMTLGQLVNLEQERLGGEHAELLKEIAEYLRILADENIIRAMIKEELIAIAAKYGDERRTEISGEEiGDVNLEDLITEETMVVSISHRGYIKRTPASTYRAQRRGGKGLKGAKTEDEDPIAHLFVASTHAYLLFFTNLGRVYWQKVYDLPELSRESRGRAIVNLLNLSEGEKIAECIAIRDFDqQGHFLMMATRKGLVKKSPLEDYSRPKKGGIIAIKLREDDEVVDVVVTKPGDEVVLSTSTGMAIRFSESDARPMGRNTSGVKGISLASGDSLVGMVVADPDATLLTVCENGYGKRTNFgpnaevvgpppadddsidtgsidtssaeaetvvaeppapaeeaaaedegdeegssgSRYRTQRRGGKGLRDIKTTTRNGTVIAVARVDDTEEVLMMTARGKLQRIAAREIKTIGRNTQGVRIMSLDDDDKLVAVVRVPRDEAE------------------------------
>UniRef50_C6CYI7(3-812:817) DNA gyrase, A subunit n=9 Tax=Bacillales RepID=C6CYI7_PAESJ   E=0 s/c=1.36 id=42% cov=92%
---MLEQFLPAYLEEVVGDRFGRYSKYIIQDRAIPDVRDGLKPVQRRILYAMYDSNNTPDKPYRKSAKTVGDVMGNYHPHGDSSIYEGMVRMAQPWKMGHVLIDGHGNWGSMDDDPAAAMRYTEARLSPIAMEILRDIDKRTVQFKDNFDNTTKEPVVLPSRYPNLLVNGTSGISAGFATEIPPHSLRETIDACIAVMARPEMTVEELMGIVKGPDFPTGGIIMGEEGIREAYTTGKGRIYIRSKVEIE-DVRGGRQQITITEIPYQVVKSRLVSAMENIRLEKKVEGISEVRDESGRNGLRIVVELKKEADANGILAYLLKKTDLQVTYNFNMVAIVNKAPQQLGIKQILNAYINHQKEVVTHRTQYELEKAEERAHVVEGLVKALNILDEVIATIKASKNRADAQNNLVAK----------------------------------YGFSERQADAILTLQLYRLTNLEITSLEKEWKETQKKIAYLRSILESEKKLLGVIKDELTEIREKYGIDRRSSIrgEVEELKVNLEVMVQSEDVIVTLSEEGYMKRTSMLSFT---RSGGDLQTAGVKEGDAISSVYEVNTIDNLLLFTRKGQYYMLPVHQIPEFKWKDTGTAVVNIVPIPKDDSIVAIIPVKDFNlPGASLVFVTKRAQVKRTELKEYMTTRSTAIAAAKVAEGDEVIRVTLSEGTKQLLLVSKLGMSIRFSEQEVNAMGRVAAGVRGMQLREDDELIAAeWVADDEGEVLVVTDLGYAKRTLLLDYPLQGRGGKGVQTFEFKEgkrvkpNGSALVAALYCKEELGIIALTSQGAQLAASSEKAPIEDRKSIGRILLPMEKNDVITTIFVRPE----------------------------------
>UniRef50_D2LZG6(5-830:834) DNA topoisomerase IV, A subunit n=1 Tax=Bacillus cellulosilyticus DSM 2522 RepID=D2LZG6_BACS4  E=0 s/c=1.31 id=40% cov=94%
-----ERYLDLPLEDVIGDRFGRYSKYIIQDRALPDARDGLKPVQRRILYAMYTDRNTSDKPFRKAAKTVGNVIGNYHPHGDSSVYDAMIRQSQDWKMRHLLVQMHGNNGSIDGDPPAAMRYTEARLSAISAELLKDIEKDTVDFMLNFDDSLEEPVVLPSRFPNLLVNGSTGISSGYATDIPPHHLGEVIDAAIHHMEHPDSTVDDLMKHIKGPDFPTGGTIQGVDGLKKAYETGKGKIVLRGKAEIE-DVRGGKQQIVITEIPYEVNKANLVKRMDELRIDKKVDGIAEVRDDTDRTGLRIVVELKKEADSKGILHYLYKNTDLQVSYNFNMVAIFNKTPKLLGLKHMLEAYINHQKEVVTRRTKFDLNKAKERAHIVEGLIKAISILDEVIQTIRASKDKKDAKDRLQ----------------------------------DMYQFTEPQAEAIVTLQLYRLTNTDVTTLEEEASELKKLIEKLEAILSSEKNLINEIKRELKEIKKKYAEARRTVIEQEIEDlkINLEVVIPSEDVRVTVTKEGYVKRSSLRSYAASNGEPPG-----MKETDRLLYSLEINTTDTLLLFTRKGSFLFLPVHQLPEIRWKDSGQHVANLVAMDNDDDILTAIPVKEFNDSEYVLFATKLGMVKKTVLSEYKAQRnSKALMAVKLKKDDEVISVTLSDGTHDIFFATHTGYGLWFTEEEVSATGQRTAGVKAINLKKDDFVVSCMSFKEESppDLFLVTQRAAYKKMKLNVFEKTSRAKRGLVMLKELKRYPHrVASLLPITKYGSIFVQTKNGNTDTIEVASIRSNDRYTNGSFLFDTGDTGEVIDVW-----FEEGDAPNTDLDDEGSSRNAINNADDD------
>UniRef50_C5B4N9(18-891:894) DNA gyrase subunit A n=1 Tax=Methylobacterium extorquens AM1 RepID=C5B4N9_METEA  E=0 s/c=1.16 id=42% cov=94%
-------VKRTSFTEEMEDSYLSYMMSTVTARALPDVRDGMKPVHRRIMFSMAESNFTADRKHVKSAKVVGDVMGQYHPHGDTAIYDAMVRMGQHWSLRYPLIDPQGNFGSIDNDPPAAMRYTESRLERLAGHLVADLGEGVVDFRPNYDSSCKEPVVLPARFPNLLVNGGIGIAVGMATNIPPHHLGETIEACLLRLANPAVTLDEIMRVMPGPDLPTGGVIHGRSGIRQAFATGRGAIRVSGVASVE-EGKAGRRRIVIAQLPYLVVKAEFVEKLAELVEEKKIEGISDIRDEsSDKAGIRIVIDVRKDADPAVVLNRLREKTDFVTNLNVNMTCLDsRGRPRTMGVLQVLGEFVDFRREVVRRRTMHRLEKTREDLHRQIGLYAATLRIDEIVALIRSSHDIDEARAALLALDFDTSGEFAQLLFEVDPDV----------PVGDTFRLSDAQVRAILEMRLSRLTGLERDKIAERARELSVEIGGHLEILNVKAVLDGVVRRELEEIKAAFPDGRRTAIEDSALDaLSDEDLVELKDIVVTVTAGGYVKRTDLPAYMGRQ------KAADEAVEDPVATTIVCTTKTPLLFFTNRGLAHAEVAHKLPEAAPNVRGRALVNFLELKAEETVQAIVALPDDRaaiEKLSLIFVTDFGTIRRNDASDFARVNKGGKVAIKLEDENgepqgKLVSVLLVSPEDDVALASRDGLCCRFNVADLRVMKsRDSVGVAGISLGRKDKVISVSVLRhfeatgtereaylaggsartkdettgepatfelpsdrmlamqeAEQLILSVTENGFAKRTSSHAYRITARGGQGVEAAKLADRTGDLVALMPVEEQDVLVITTDAGKTFRTSAAEVPIMARGTQGTRAFALEGRQAIVSVVKIAAE---------------------------------
>UniRef50_C1EGN9(107-963:963) Predicted protein n=1 Tax=Micromonas sp. RCC299 RepID=C1EGN9_9CHLO   E=0 s/c=1.16 id=40% cov=93%
-----ERIVDLELHLEASQSYLSYAMSVIVGRALPDVRDGLKPVHRRILYAMHELGLDSKKPFKKCARVVGEVLGKFHPHGDQSVYDALVRMAQDFSMSSALVDGHGNFGSLDADPPAAMRYTECRLKPAAEAMlLADIGLDAVDFTETFDGSQTEPAVLPARLPNLLINGSTGIAVGMATSIPPHNLREVANALVRFASDPErCTLEDLLEVMPAPDFPTGGIIVqQRGGFKEMYRTGKGGVNLRGAATVEKVSGGGrngqaRDAVVITSIPYQTNKASLCEQIADLVNSRTIEGVSDVRDESDRDGMRVVVEIRRGADANFVLDQLYARTKLQTRVSVNLVGLVGREPKVLSLMEIMREFLAFRCDAVERRARHELQKASGRLHVVEGYLAVQAAPDAVVAAIRAAKDGPTAQAALQEKP---------------------------------FWLSEKQAEAVLAMPLRRLTGLEHDKLKTEEAELTARVEDLTGLLGDRSRVIATVAREAKELRDTFGVDRRTDIDTDAQihakKMNVTLDMLNSPSLVIMTNRGYIKRIDPAVFSKQNRATRGRNMGKMRGGDEVTKVTHCNGLDTVLFFTDRGRVHAVRAFNIPQASTSALGTPFTRVLKLAEGESITAMLPVDtteepGEEGETSLCFVTARGLIKRTCASEFVGIRNNGKKALVLRKGDRLKHVDIVKKGDGIIIGGIDGSVIHFDADSVRAQGRAAAGVKAMAFKPDglddtsedddtsealpanasagdveddSEEDGEDEDAKGPMLFFVSSDGRGKRISVAQFAQQSRAGrgkKGMGLMKGSKLAALCLTGLDSDEHEHVIIGSQGGVMNRYDVASIrPQSGRAAKGVNVMKLSDGDTVRDITLLPAELGDDE----------------------------
>UniRef50_D1C5K4(12-812:813) DNA topoisomerase (ATP-hydrolyzing) n=1 Tax=Sphaerobacter thermophilus DSM 20745 RepID=D1C5K4_SPHTD  E=0 s/c=1.16 id=38% cov=90%
-----ETIETEEFSTLFEDAFVQYALAVVTSRALPDARDGLKPVQRRILWCMYENGHRSNRPTVKSASVVGDVLKSYHPHGDSAVYDAAVRMAQDFTMRYPLIEGQGNFGSIDGDAAAAYRYTEMRLSPIGELLLRDIEQETVPFEQTYLQmpNVVQPVYLPARIPP-ICNPSSGIAVGLSTDIPPHNLREAIRAAIALLDNPEMTVDELMKILPGPDFPTGGRIIGTDGIRAYLESGKGRLVIRGEVRLEEELR--QRNLVVTEIPP-ISRSRLVRSIINAVNDGKVTGVTDVRNESDDEkGTRIVVELERSATPEVVLNQLYRFTDLQTAVNVNMVFLFGDpgqparQPRRTGMLDLLRYWNRHQIDVITRRAEYQLRKAQERLHVVEGLIIGAAHADEIVRIFQKARDRNVAKEKIKVK----------------------------------YNLTDIQADVIANMTLAQVTRLDAAKYAEEKKELTKRIKELQALLASEAKKVALLKEELTAIAQEHGDDRRTRIDREGQEeiASVASLIEERPILIVASQSGRVKALPENAFKRARAG-------RTARGEGLAAIVPASTLDYLLVLTRGGRVYLSRGHEVPAGTRASSGEPAQKVFGLKPDEALATILPVNELTEDRYVVWFTANGKVKKTSLAEYRTITSAGLNDLRLLGDDRVVAATLSESGGEYLVIASNGQALRFADDEVRATGRDGQGVNAIALKAGAEVVTALAipPKSDGDVLVVTAQGMGKRTALKDFPARRRATAGVAAITLA-KGDRIAGAALVTPDDDVVLGAAGGQALQVTVKDLRRQGRATKGSRLLEVAKNDHVATIARV------------------------------------
>UniRef50_B5IIX4(19-829:834) DNA gyrase/topoisomerase IV, A subunit domain protein n=1 Tax=Cyanobium sp. PCC 7001 RepID=B5IIX4_9CHRO  E=0 s/c=1.14 id=38% cov=84%
------RIQPIALHQEMQRSYLEYAMSVIVGRALPDARDGLKPVQRRILFAMHELGLTPDRPYRKCARVVGDVLGKYHPHGDQAVYDALVRLVQTFASRHPLLDGHGNFGSVDDDPPAAMRYTETRLAPIAHEgLLDEIGNDTVDFAPNFDGSQQEPTVLPAQLPFLLLNGCTGIAVGMATNIPPHNLGEVVDAMIALIRKPDLSDEKLFALVPGPDFPTGGEVLLSSGVRDTYRLGRGSIPMRGVAHIEEvqpgKGRHRRSAVVITELPYQLSKAGWIEKLAEQVNDGKIGGIADIRDESDREGMRVVVELRRDANADTVLAELQRRTALQSNFGAILLALVNGQPVQLSLRRLLQEFLDYRELTLIRRTRHALRRCEDRLEVVEGLIKALDALQEVIAMI----------------------------------TAAADAASARASLQVRLDLSERQADAVLAMPLRRLTGLEQESLRQESEELRTERTRLRHLLDDRDSLLEAMVAEFRALKKRYGTPRRTRLVEGGDDLvaqraaaarpnaelqrqqALEALASDSRVLIQADRA--VKIVTPQVLGRLHLEEP----APLGEHPAPAQlLLTVASQPQVLAFTTDGRVAVLR-WEFAGQQPG----PLERFLPDSlEGASVMQVLPLQEgSDPHLSIGLLSSDGRFKRLPLDDLQDLSGRAATVLKLKEGVTLQRVVPCRSGAELVVASSTGRMLRLeaNEEQVPLMGRTAQGPVLMRLLPDEQIVGAACVPASGSVLLASRQGQVKKLAVESLRRCERGDLGLIGIRFSQRGDALVAL-----------------------------------------------------------------------------------------
>UniRef50_Q57532(551-1245:1273) Mle gyrA intein n=207 Tax=cellular organisms RepID=GYRA_MYCLE   E=0 s/c=1.33 id=45% cov=78%
--------------------------------------------------------------------------------------------------------------------------TEARLTPLAMEMLREIDEETVDFISNYDGRVQEPMVLPSRFPNLLANGSGGIAVGMATNIPPHNLYELADAVFWCLENHDADEETMlvavMERVKGPDFPTAGLIVGSQGIADAYKTGRGSIRIRGVVEVEEDSR-GRTSLVITELPYQVNHDNFITSIAEQVRTGRLAGISNVEDQgSDRVGVRIVIEIKRDAVAKVVLNNLYKHTQLQTSFGANMLSIVDGVPRTLRLDQMICYYVEHQLDVIVRRTTYRLRKANERAHILRGLVKALDALDEVITLIRASQTVDIARVGVVE----------------------------------LLDIDDIQAQAILDMQLRRLAALERQRIIDDLAKIEVEIADLGDILAKPERRRGIIRNELTEIAEKYGDDRRTRIIAVDGDVNDEDLIAREEVVVTITETGYAKRTKTDLYRSQKRGGKGVQGAGLKQDDIVRHFFVCSTHDWILFFTTQGRVYRAKAYELPEASRTARGQHVANLLAFQPEERIAQVIQIRSYEDAPYLVLATRAGLVKKSKLTDFDSNRSGGIVAINLRDNDELVGAVLCAADGDLLLVSANGQSIRFSATDeaLRPMGRATSGVQGMRFNADDRLLSLNVVREDTYLLVATSGGYAKRTSIEEYPMQGRGGKGVLTVMYDRRRGSLVGAIVVDEDSELYAITSGGGVIRTTARQVRQAGRQTKGVRLMNLGEGDTLLAIARNAEE---------------------------------
>UniRef50_O67108(5-731:744) DNA gyrase subunit A n=2 Tax=Aquificaceae RepID=GYRA_AQUAE   E=0 s/c=1.24 id=43% cov=83%
-----ENLVEIPIEEEVKQAYIDYAMSVIVGRAIPDVRDGLKPVQRRILYSMYEMGLLPDKPFKKSARIVGETLGKYHPHGDQAVYEALVRMAQDFTMRYPLIIGQGNFGSIDGDPAAQMRYTEAKLSPLAVEMLTDIDKDTVDFQPNFDDTLMEPEVLPSKFPNLLCNGTSGIAVGLATSIPPHNLTEVGNALVKLAQNPQISVDEIMEILKGPDFPTGGVIENFAQVKEIYKTGRGIIKVKGKAHVE-KVQGGRERIVITEIPYQVNKAELIKKIADNVRNGKIKEISDIRDETDKEGIRIVVELKRDAKGEEVLKKLYKYTPLEKGFPVNLVVLIDKEPKLVDIKTLLREFIKHRLEVILRRSKYFLKKVQDRLHIVEGLLKAINFIDDIIERIRRSKDASEARNYLMEE----------------------------------FGLSEKQAQAVLDLRLQRLTSLEREKLLEEEKELREKIEYYKKLVASEGERIKVFIEETEELVKKYGDKRRTFIGGVKE-------VKEGSITVAVLQDGSI--IPVEELPLEKAPVVNILRVPFTEG--------------LFLVSNRGRVYWIAGSQALQGSKVSL---------KSREEKIVGAFIREKF--GNRLLLATKKGYVKKIPLAEFE-YKAQGMPIIKLTEGDEVVSIASSVDETHILLFTKKGRVARFSVREVPPSTPGARGVQGIKLEKNDETSGLRIWNGEPYLLVITAKGRVKKISHEEIPKTNRGVKGT---EVSGTKDTLVDLIPIKEEVELLITTKNGKA-----------------------------------------------------------------------
>UniRef50_A2BND1(4-780:813) DNA gyrase/topoisomerase IV, subunit A n=7 Tax=Prochlorococcus marinus RepID=A2BND1_PROMS  E=0 s/c=1.02 id=36% cov=87%
-----KNFTSISLQEEMQRSYLEYAMSVIVGRALPDARDGLKPVQRRIIFAMYELGLTPDKPFRKCARVVGDVLGKYHPHGDQAVYDALVKLVQNFSTKYPTLDGHGNFGSIDNDPPAAMRYTETRLAPIAHKgFLEEIGSETVNFSNNFDGSQKEPDVLPAQLPFLLLNGSTGIAVGMATNIPPHNLGEIVDGLVTLVKNKDISDKKLFNIIKGPDFPTGGELIYSRAIEELYQTGKGSITIRGVINTEEvnlgKGKHKKNAIIIKELPYQINKAGWIEKLAELVNAGKIIGISDIRDESDRDGMRIVIELKKDSNSELVISNLYKKTTLQTNFGAIFLALIKGKPVQLNLKKYLNYFLEFREETIRKRTFYFLKNTLDKLEISEGLSKATKDIKKVIAIIEESENSVQARSKLVEK----------------------------------FFLSEKQANSVLDMPLKKLTNLEKNQIDNEIKNLAEKKNYFQKLLNERELLLKLLIEELLILKKKYNVIRKTKIIKNLNQNEeletlnnqiLEDFI-NKKTKLYIDNRLYLKRMILSNYKKSFEGVN-----KIIDNKNIQKFICnIEKNTKLIGITNTGRVF-----NIDWESSINKDYKLDNkiLGNIHPSE-IINFHSIKK-ETRNYLCILNSDGRFKKVLFDKDMIKSNRSFTITKLKNNLKTVDSFISNESKNLIILTSIGRIFKFNLSNkfLTATSKQSKGLIIAKLLPTEKIVSCCTFHDGENIFLISKQGKIFCINSNEIYCSNEYSLGYLNEKTQLKNDYFLKIMA--SNHYLDIETNKNKSARLDLNKI---------------------------------------------------------------
>UniRef50_A3VFM2(57-784:856) DNA topoisomerase IV, A subunit n=11 Tax=Alphaproteobacteria RepID=A3VFM2_9RHOB  E=0 s/c=1.03 id=40% cov=78%
------------------DRYLTYALSTIMNRALPDARDGLKPVHRRILFAMRELRLNSGGRFRKSSKISGDVMGNYHPHGDAAIYDAMARLAQDFNVRYPLVDGQGNFGNIDGDNPAASRYTEARMTIVAEALLEGLDEDAVDFRENYDGTLREPVVLPATFPHLLANGAAGIAVGMATNIPPHNISELVDACLHLIKTPDARDDTLLNYIPGPDFPTGGVIVEpRENIAEAYRTGRGSIRLRSKWEVE-DLGRGQWQIIVTEIPYQVQKSKLIEKLAEVIQTKKVPLLADVRDES-ADDVRIVLEPKtRNVEPEMLMGLLFRNSDLEVRFSLNMNVLIDGlTPKVCSLKEVLRAFLDFRREVLIRRSQHRMEKIDHRLEVLEGFIIAFLNLDRVIDIIRYDDDPKAA---LMYEDWSRPhqdtiaratnehdyvsplagiDVASLELREDETATAPEIITDNTGSGATPKRFvgrseglSDVQADAILNMRLRSLRRLEELELIRERDALMEERAGLEDLLDSEDLQWGRIGDELKDAKKKFGKDyvagaRRTQFAEAAEvpDVPLEAMIEREPVTIVCSQMGWIRAMSGHV--------DLTRDFKFKDGDGPRFAFHAETTDKIIVFAANGRFYTLGASNLPGG--RGMGEPLRLMVDLPNDVEIIDMFV---HAPDRKLIVASKGGNGFIVPEADVVAQTKNGKQVLNVSD-DVAKLVKPVAG-DHVAVVSENRKLLVFPIAELPEMGR-GKGVR---------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_P75352(1-756:789) DNA topoisomerase 4 subunit A n=2 Tax=Mycoplasma RepID=PARC_MYCPN   E=0 s/c=0.97 id=33% cov=80%
-----------AIEDVFAFSFSKYAKYIIQDRALPDLRDGLKPVQRRILYGMYQMGLKPTSPYKKSARAVGEIMGKYHPHGDASIYDAIVRMSQAWKNNLTTISIHGNNGSIDGDNAAAMRYTEARLSPYGFELLKDIEKQLVPFVNNFDDSEVEPSVLPTLLPNLFINGTSGIAAGYATNIAPHNVGELLDGLSYRIENPDCDLKAILKIVKGPDFPTGGLVYFEQELANIYQTGKGKFVIQAKY--ETNTAFGQNQIVITEIPYETVKANIVKQIEELISDNKLSALESVIDSSDRSGIRIIINHKDFLSADKIMAFLFKHTQLQVNFNLNNTVIANRCPVRVGLLAYFDQFLAFAHELIINSAKYDLALANKRLEIIKGLIKAVSMIDEIIRLIRRATDKQDAKTKLIDK----------------------------------YAFTLNQAEAIVSLRLYQLTNTDIKVLFAEQKELEQTIQTAERLIAKPQARNQLLQAQFFQYKKQFNQPRRAQIVGliEKQKVQDSDFIEHKEVGLLISHDGiYFKFEPEQLAK--------HLVEFKSEQDQLIFGGVVQNSDYFFMVTSLGNIITVPIYKTLSNTKTKMNELLAKKPILMEDEKLVLAGIVNPDKMEQQLLVLTSQcGMVKRVELSKVINTKQiKSSCCMALRERDKLVNAFVqTKGEPKLVcLVSSSNSFATFLAEEIPIISNKGIGVKGIKLKAEEKVRFAMPLQDNDALVVINSDG----------------------------------------------------------------------------------------------------------------------------
>UniRef50_C6WIH8(401-1128:1143) DNA topoisomerase (ATP-hydrolyzing) n=15 Tax=Actinomycetales RepID=C6WIH8_ACTMD  E=0 s/c=0.99 id=39% cov=77%
--------------------------------------------------------------------VVHNCMGKYHPHGDTAIYDAMVRLAQDFSLNTPLIDGHGNFGSPD-DGPAASRYTEARMSGAAMLLVGELDEDTVEFRPNYDGSLTEPAVLPAAFPNLLVNGTSGIAVGMATNMIPHNLGEVVAAARHLVKHPDADLEKLMEFIPGPDLPTGGMLLGLDEVRKAYETGRGVVRMRAtVTTGPLEGSRGRQAITVTELPYGVGPEKIIEKITDEVNkSKRLTGIADVKDLTDREnGIRLVIECKVGVNPQALLADLYRLTPLEQSFGINNLVLVDGQPQTLGLKALLEVFLAHRYEVVTRRTRFRRRKREDRLHLVDGLLKALIDIDKVIKLIRRSENAQAAKEGLVST----------------------------------FALSETQAAYILDTPLRRLTRFDSVELEGEQERLRGEIAELSTILDDDKVLRRVVSNELGKVAKDLSAERRTTLLDGDLKEVLAAsrtsgplEVADDPCQVVLSATGLVARTAAESEEA----VEGRKRSGRAKHDAVAATVHTTARGQVLLVTSRGRAFKTDVLPLPVLPQGegtlslSGGVPVRELVGLEAGERVVGIAPLGE-TDSPGLALGTKQGVVK-VCAPEWP-VRSDEFEVIGLKAGDEVVGAQwLADGQEALVFVSSEASLLRYAASLVRPQGLRGGGMAGITLPGEASVVFFGAVRTDdaehGEPVVVTSTGQsVKVTPFDLYPAKGRATGGVRAHRFLKgEDGLVLA------------------------------------------------------------------------------------------
>UniRef50_B3LCM1(175-1098:1173) Dna gyrase a-subunit, putative n=1 Tax=Plasmodium knowlesi strain H RepID=B3LCM1_PLAKH  E=0 s/c=0.72 id=30% cov=85%
---------DVEICDLLSKNFLSYANFLILNRCLCDYRDGLKTVQRRIIWSMYEINKGAEKsSYKKCARIVGEVIGKYHPHGDKSVYDALVRLAQKHHNNNLLINGYGNFGSVEY-NAAAMRYTEAKVSNFCYDILLDeINDENIEYVRNFDGNEVEPKVLCSKVPLLLINGCSGIAVSILSNIPCHNLVDVINCTISFLLDANIRDDELAAIIKGPDFSTGGIIISKASqLQNVYQTGKGNIEIRSNVFLEYTKndkvqvihvndlpnvnaedidTRGSKKLVIKNLPPNVKPNELIENMINILNEKKNEHeniLQKIRDESEKEDMRIVLELRKNSQVEQIndfVSFIFKYTQMQITYHCNFVCIgHQNSYTQFSLKSFLQLWCENRINFIKKNLTIKNQNLQKELHIIDLYILIQKKILEIISFLQKNQNIEEIKNFFKEN----------------------------------FKLNDYQIHHILSMKIQKLVNIKNVDFCTHKEQILARMEQNRDLISNVDKIKRLIIDQLTYIKNKYGinsvgrfappqsvkyryvyinppernhhfkehslalvnaerdgpsgyggdaedlkgerkiskkdtlsdeirnqeeqqtpveDPalpkarnlrgvkkidpttqyRQTYIDSIHTDV--KNVYNNDYVLVLITYGGYVKKIkvaeklknhqnniiklsnvkyilkeneekklkdggaPVEAANVVESGEEGANSMSAKSSSLnaincykVKKSILCRNKDKLLLTDSQNKAYILNVYDLQTSSYDSKGTPINQVIHCSKN-----ITGMTKFEENkKYLIVCSENGKMKVINNDVFLKKKKKG---IRLFKNKKDIHFSYCNFSDNCIVGTASGHIIQFPLANFKISKKNSLGNKCINLGKNDKVVDLLAYDNDEKnvgnfqIIFLSKGGHGKMINLEELKVQKKKGKGYKIMKFKraKRDAVLQGEVAKEEDKE---------------------------------------------------------------------------------
>UniRef50_Q00TB8(32-451:475) DNA gyrase A subunit (ISS) (Fragment) n=1 Tax=Ostreococcus tauri RepID=Q00TB8_OSTTA  E=1e-155 s/c=1.31 id=43% cov=48%
-----------------------------------------KPVHRRILFGMHELGLRSDKPHRKCARVVGDVLGKFHPHGDGAVYEALVRLAQDFSMSAPLVDGHGNFGSLDDDPPAAMRYTECRLNKVSEkALLADIASECVGFTETFDGSQTEPEVLPARVPNLLINGSSGIAVAVATNMAPHNLGEALSGRSH-------------GTPPGAGFP---------------------------------XXXXXXX----------------------------------------DGMRVVIEIKRGHDASTVLAELYKKTRLEVNYNVNNVALVGNKPTVMPLRDMLDEFIKFRVDTIERRTRFMLGKAQDRKHLVEGFAFVLTDADGVVKIIRGSKDGPSAAKKLREKHG----------------------------------LSEIQSDAILAMPLRRLTGLEADKLDAELKDLNGQIEYYQGLLNDKSKVIDVLIQEAQEAKTAFARERRTTLEQtGPSDGVIEDEGPPKDNIITLSERGYVKRVCPTNFGAQARGTRGKRMSKLRANDELS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A4T3N2(26-677:716) DNA gyrase/topoisomerase IV, subunit A n=6 Tax=Mycobacterium RepID=A4T3N2_MYCGI  E=1e-136 s/c=0.75 id=31% cov=72%
---------------------LTFALYSVSDRAIPSAFDGLKPGQRRLLYQMHESRLLPGNKPQKSSKICSAVTGNLHPHGGASMYGAAALMAADFQ-RVKVIDGQGAFPRIQGDIPAADRYTEMRLSAPGAALTAELDSHAVPMVATFDGEWTEPTVLPAQWPVLLCNGAVGIAEGWATKVPAHNPREVMAACRALLKTPNMTDDRLVKLIPGPDWGCGASVIGTDGLREYITTGRGLFTVRGTVSV------DGKNCIITELPPGVASGTVQDRIRALVESGEMAGVADMSDLTDrRNGLRIVVTAKRGHSAEQIRDQLLALTPLESSFAASLVALDENRvPRWWSVRELIAAFLSLRDSVVLHRSEYRLEKVTARRHLVAGLMTIHLDIDTAVAIIRASDTVDDARLGLQER----------------------------------FAIDAVQADYVLALQLRRLTKLDVIELQAEAEKLDAEFAALTELVSNPDARRKVIDQELVETAKLFKGPeydRRTVLDYDATPVAANN-----------SEDGPRERKVNAAWRLDDRGVFSDSHGTLLSS---GLGWAVWTDGRIKFTTGGGLPFKIR--DIPVSP------------------DITGLL--------------------------------QSGVLA----------------PGSHLALITRRGRVLRIDPAAVNPQGAAGNGVAGVKLvadDPEDRVIAALPVScaNGEAILSISEKSW-KVTEVADIPVKGRGGAGV--------------------------------------------------------------------------------------------------------
>UniRef50_A4ECR3(1-335:339) Putative uncharacterized protein n=1 Tax=Collinsella aerofaciens ATCC 25986 RepID=A4ECR3_9ACTN  E=1e-103 s/c=1.13 id=39% cov=38%
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MVVTITHTGYVKRIPVAAYRAQKRGGKGVSGVNLKEDDVIDEMFIASTHEYVLFFSSKGKVYRLKVHELPVGTRQARGTAIVNLLPFEEGEKIASVISCREFPANEYLMFATKSGMVKKTVMSAYDRSRRDGLIAINLRDDDALLNVRRVREGDKIILATTAGKAIMFSEEQVRATGRDTSGVRGIGMKDGVSVLGMEVTNGNGDLFVITERGYGKRTPVADYPEQNRGGQGVYTIQMTERKGNLAAMKTVGPQHELFIVTEGATVIRVKTDEISQTGRATQGVKMMTVDDNDRICAVARMTAAKEKPEGEGAEA-AADTEETPVDLGDGNDMPED-
>UniRef50_D1QVZ0(122-668:978) DNA topoisomerase 4 subunit A n=2 Tax=Prevotella RepID=D1QVZ0_9BACT   E=4e-80 s/c=0.55 id=30% cov=56%
--------------------FLDYASYVILERAVPHIEDGLKPVQRRILHSMKRMD---DGRYNKVANIVGHTM-QFHPHGDASIGDALVQMGQK----DLLIDCQGNWGNIlTGDRAAAPRYIEARLSKFALDVV--FNPKTTDWQLSYDGRNKEPITLPVKFPLLLAQGAEGIAVGLSSKLLPHNLNEICDAAIKYLRGEDFQLY--------PDFPTGGAID-----VSKYNDGQrgGVLKVRAKIE-----KLDNKTLVIREIPFSKTTTTLIDSILKAIDKGKIKA-KRVDDNTAAE-VEIQVHLAPGVSSDKTMDALYAFSDCEINISPNCCVIEDNKPCFLTVSDVLRHGVD--------RTMGLLRKELqiRRGELLEQLFFAsLERI---------------FIEQRIYKEKKFEQAADMNEAVAFVDLKLTPFKPDFIREVTRDD--------ILrlmEIKMQRILKFNKDK----ADELIARIkAEVAEIEHDLEHMTDVTINWFMFIKNKYGNehPRHTEIRSFDTIDSAKVVEANQKL--------YINRQ------------EGFIGTGLKKDEFVCN---CSDIDDIIIFYKNGKY------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B2ZYK7(37-504:514) Type IIA topoisomerase n=1 Tax=Ralstonia phage RSL1 RepID=B2ZYK7_9CAUD  E=2e-51 s/c=0.44 id=29% cov=45%
-----------------------YGTTVNLDRSVPDLYDGLKPVQRRILWSASQVCRT---QFEKSARLTGHCMGAYHPHGNSAIYSAAVNMVQHPS---PTLLGKGNFGSM-TDGAAAERYTNVRLSHYGQTFFDSdyINAETTSFVPNYDDKDVEPVTLPAQLPNVLLNGGEGIGVGITTKLPTF--------------TPESVLEVLNRMFKGEklqavDFAkTlkyhhkwGGQLVrskeNQAQWKQMFV---GSM---ANLQFEAvlDLDRDHKRMTISSWPPGTNLETFMKKVRAMPECHKC--------FNSKGTTTYQIECKPGFNydqFDKFVEKVRKATMQRQAFKINVTrreaKTVDGVTTfkteflALSVPDLILQWCRMRVALELKSLAYRIKKQEAAIAYSKLLIYAVDKLDLIFKALRQS-DPDASLQKL-------------------------------------LKITAEQAKQILDLQVRKLSKLDQSKLKGTLKTQEQELKQLQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q56C44(2-347:387) Gp52 DNA topoisomerase subunit n=1 Tax=Enterobacteria phage RB43 RepID=Q56C44_9CAUD  E=1e-38 s/c=0.47 id=33% cov=37%
-----------SIKDVVQVEGLTFALYTIYSRAIPHLVDGFKPVHRFFVHSAAKGG----SGFQKVASIAGGVaIYGYH-HGETSVEEALSLMAAHWCNNIPLFDRDGFFGSRLVKKPGAPRYIYCKLSPLfkAIYMDEDL---TIP--------HEDPEHLPPAyylpiIPMVLVNGFRGIAKGYATNIPPHDPVSVLNGCVSYLNGKDFTLD-----LKYPQF--------KGDIVDG--------TMYGKYELQ-----GKTKLVITEIP---VKYDRVKYIAILDKLEEKGCIVSYKDLS-KEDFRYEITLKREYANGLTHEKILKDFGLIENSNPNINVIFNGklhsyeRPETL-----LKDFVDIRMTVYQQRIEKRIQEAK------EALARALAKvefIDQMIE------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q76Y98(18-416:438) Gp52 topoisomerase II medium subunit n=1 Tax=Aeromonas phage Aeh1 RepID=Q76Y98_9CAUD  E=1e-35 s/c=0.39 id=29% cov=44%
----------------------EFAMYTIEERALPSMVDGLKPVQRYILFSVLK---NAGREFKKNAAVAG-VISEYgYNHGEMAAMDAACLMASTWNNNFPVIQGRGNFGCRAVQEGAAARYIFCSKHERFESMFKDmelLEESTA------DGSILPRYYLP-ILPTVLLNGVSGIATGFATKIMPHSVQSVAKCVEQVLKSGKCDEPE----IQFPKF--FGKILSIEG-----ET--------QSWKVEGDYElSGKTKLIINELPPKYDRLKYVTHLNKLVETDKIVGY----DESkmkDREFC-FKVTLKRDFDVshENII-KVFKLSQ---NVSQYIRVIDQNG----NLKpydnasDLIVDFVNFRFNVLQKR------------------------IDNAIIATREKLDFAQAKVDFIKLVLADKIVFNRQTRKQVIEQINAFDELKTY------------ADQLVQMNLYHMTEDEVAKLEKQVAELQKE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q3QZ99(9-336:352) DNA gyrase C-terminal repeat, beta-propeller n=3 Tax=Gammaproteobacteria RepID=Q3QZ99_XYLFA  E=2e-34 s/c=0.46 id=23% cov=33%
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FGLSDAQTEYILDTKLRQLARLEEMAIRSEQDALTKERDEINVILDSDVQLKKLIKDELLADAKTFGDARRAPLVArqAAQAIDESELVASEPMTVVLSEKGWI--------RAAKGHDVDPSGMSYREGDRLLAAVRTRSTHQVSFLDSEGRAYSTLVHTLPSA--RGNGEPLTGRFSPAPGASFQAMASA---DNDKLFVLASSHGYGFITRFENLTGRNKAGKAMIHLTPGAQVMGLAPLTDvqHDRIVAVTSAGNLLAIAASELPELDK-GKGNKLIDIPKtklaTERLVAVIAVASSHTLLLYS-------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C4MZZ9(18-388:459) Gp52 topoisomerase II, medium subunit n=2 Tax=unclassified T4-like viruses RepID=C4MZZ9_9CAUD  E=2e-31 s/c=0.38 id=29% cov=37%
-----DTFTPRDLKSIIDNEALAYAMYTVENRAIPNMIDGFKPVQRfvvaRCL----DMARGNKEKFHKLASIAGGVadLG-YH-HGEGSAQEAGALMANTWNNNFPLLDGQGNFGSRLVQKAAASRYIFARIgTNFAK-----VYKDT-EYAPVHADVEHKPPafYLP-IIPTVLLNGISGIATGYATNILPHSFDSVKKAVLQVLQEKRVTKPKVAY----PEF--------RGDVVEIEP---GSYELRGTYKF-----TSRTQMHITEIPYKYDRETYVAKVLDPLEDK---GYITYDDDCDENGFGFKVKIRKEYELPTEENK--KHEKIMKDFGLIerrsqNLTVINEKGKLKvyeDVVELIRDFVEVRKTFVQKR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q6PUA3(671-1131:1662) DNA topoisomerase 2 n=4 Tax=Tetrahymena thermophila RepID=Q6PUA3_TETTH  E=5e-31 s/c=0.30 id=26% cov=47%
------------------------------ARSIPSLCDGLKPGQRKILFACFKRNL---KNEIKVAQLSGYVAehSAYH-HGEQSLESTIVGMAQSFvgtnNINYLMPIGQ--FGSrnMGGKEAASARYIHTCLNKITrcvfpepdDHILYYLEDE---------GQQVEPIyYLP-IIPTALLNGADGIGTGWSTSIPCYNPRELVDSIEKRMM--GVPFTDLLPWYKG--F-TGEISNNE----------KSQITVSGKYHLVNE-----TTIEITELP----IKKWIRDYKNFLEEKlestkdKDPEIEDIKEYHAGNRVHFVVKMSEKQMEKVQREGIDKYFKLQSTIPTTNMVLFNHEGKLTryaNICEIMEEFYEVRLNAYKRRKEYLVSKIERDLEILsnkKRFILAV--INESIRV-RNAKRKDLIKE-LSVQGYVQMKDMPKIKSSKLTSQLEQEQNQDSNEENFETNPNEINAKeynYLLSLPMWSLTYEKVEEIKQEQKNKQDELDKL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A5E7X7(741-1238:1492) DNA topoisomerase 2 n=4 Tax=Saccharomycetaceae RepID=A5E7X7_LODEL   E=1e-27 s/c=0.26 id=28% cov=51%
------EMNEIPISDFINKELILFSMSDNV-RSIPSMLDGLKPGQRKILYGCFKRKLKNEIKVAQLAAYVADV-SSYH-HGEQSLVQTIIAMAQNFvgSNNINLLKPNGAFGSraTGGKDAAAARYifTE--LNEITRTIFNEAD----DPLLNYlqdDESTVEPQwYLPV-LPMILVNGADGIGTGWSTNIPSYNPLDIVANLRRLMRGEPM--EEMNPWYKG----------WYGDIEKV---GPQKFKISGR--IEQIDDN---TIEISEVPVktwtNTVKEFLL---AGLGNEKTVQWIKDM-EEQHTTSIRFVVKLSDAEMAKALSVGLLEKFKLVSTISlANMVAFDpHGRIKKyLDVLDIVKDFYFVRLEYYEKRKNHMLEILQHK-HsmISEQARFIKMIIDkqlsvankkkkELIGILEANKFLKFTKDGRPIEQVVVDDDDDDEDEDVIDGAGGAGVDGIAGGEADISQLNLKEVdenptnehrpetvsssyDYILGMTIWSLTHERYVKLLAEKEKYQNQLQDL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_P90520(808-1241:1284) DNA topoisomerase 2, mitochondrial n=1 Tax=Dictyostelium discoideum RepID=TOP2M_DICDI  E=1e-24 s/c=0.27 id=30% cov=34%
-------------------------------RSIPSLIDGLKPGQRKILFASFKRRLTNE---IKVSQLSGYVAEQtsYH-HGEQSLNSTIVKMAHNFvgSNNLPLLTPSGQFGTrLQGgsDSASA-RYIFTKLEPVARYLFNELD----DPLLNYLEEEGEsiqPDYYIPIIPMLLVNGSEGIGVGMSTSIPLFSPIDIIDQLMLRLNN-QVALKKLIPWYRGfkgtisPD-------------RHTYRT-NGVIKLVGR------------NLEITELPIGRWTSDYKEVLNDLIDKDVIKSFQ----ESNTEnSVHFTILLNNNqleQMEDLTENELIKLFKLSASLNFHLTCFDENSKiqKLESVEEIIDQFYKVRLQFYGKRREY---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q02880(733-1202:1626) DNA topoisomerase 2-beta n=175 Tax=Eukaryota RepID=TOP2B_HUMAN   E=5e-24 s/c=0.24 id=25% cov=47%
-------------------------------RSIPSLVDGFKPGQRKVLFTCFK---RNDKREVKVAQLAGSVaeMSAYH-HGEQALMMTIVNLAQNFvgSNNINLLQPIGQFGTRlhGGKDAASPRYIFTMLSTLARLLFPAVDDNLLKFL--YDDNQRvEPEwYIP-IIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRMLDgldpHPMLPNYKNFK----------GTIQ---------ELGQNQYAVSGEIFV-----VDRNTVEITELPVrtwtQVYKEQVLEPMLNG-TDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDhmgclKKYETV--QDILKEFFDLRL------SYYGLRK-----EWLVGMLGAestklnnqarfiLEKIQGKITI--ENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEDETQNQHDDSSSDSGTPSGPDFNYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A8Q6X4(736-1160:1178) DNA topoisomerase 2 n=1 Tax=Brugia malayi RepID=A8Q6X4_BRUMA   E=1e-23 s/c=0.27 id=28% cov=46%
-------------------------------RSLPNVVDGLKPSQRKVLFTMFG---RYERGEIRVSQLAGAVSqycG-YH-HGEESLVNTIVRLAQDFvgSNNLNLLLPLGQFGtrlSGGEDVASA-RYIYTSLSPLARAIFPHPDdkvlKNLVE-----ENALVEPEWYCPIIPMILINGAEGIGTGWATKILPRCPRQVISNAQRLIDGR--PLQDML-----PHF------RKFQG--TIYETAPRQYSISGKVSYRRLKSGLRA--IITELPTGIWNNKYKEKVLDsAIKNGIISNYEELHTESNVHFILHVIDkpLLSDKKQIKALNRLLK---LRSVASENSMILFDEKNVLQkydSTREIFQEFFEVRRQKYIERRECELV-------IMEGKLKFIENqvrfVNAIIngEIIIKKKNRAEIIAQLAEKGFDSNPMKAKNATDGNCNPPDFA--------------------YLLDMPLCRLSNEEILVLQEKRSQLWERFKSLKS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q4RIW2(847-1334:1568) DNA topoisomerase 2 (Fragment) n=1 Tax=Tetraodon nigroviridis RepID=Q4RIW2_TETNG  E=2e-23 s/c=0.23 id=29% cov=49%
-------------------------------RSIPSLVDGLKPGQRKVLFTCLK---RNDKREVKVAQLAGSVaeMSAYH-HGEQALMMTIVNLAQNFvgSNNLNILQPLGQFGTrINGgkD-AASPRYIFTMLSPLAKLLFPAVDSNLLKFL--YDDNQKvEPEwYIP-IIPMVLVNGAEGIGTGWACKIPNYDVREIVNNI-----NRMLSRQEPLQMLP-----------SYKGFKGvIHELGQNQYLVSGEVSV-----IDKNTVEITELPVrtwtQAYKESVLEPMLQG-SDKTPALISDYKeyhtDTTVKFLVRMSEE--KLAQAEA--AGLHKVFKLQSSLTCNsMVTACFHRPEHVlfdhmgclkryeSVQDILKEFFELRLHYYkLRRdwlvgslgaeaaklsnqARFVLEK-------IEGKISIENKSKR--ELIRmlvqkgFESDPVAAWTRAQEKELRRFQSKREPRQAQEEDEGNDSDSSLDSGSSSGPNFN-----YILNMPLWCLTKEKVEELLKQRDLKRGELNELQR--KSPEDLWKedlaVFVEELEKL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D0MV61(685-1161:1329) DNA topoisomerase 2 n=2 Tax=Eukaryota RepID=D0MV61_PHYIN   E=3e-23 s/c=0.24 id=28% cov=48%
-------------------------------RSLPSVVDGLKISQRKVLFACMKRKLTSE---VKVAQLAGYCSEHtaYH-HGEASLHSTIVNMAQDFvgSKNLPLLFPSGQFGTrlQGGKDAASPRYIFTLLQKHTRLVFPEEDDALLRYADD-DGFPVEPVFYVPIIPMLLVNGAEGIGTGWSSSIPCHHPVLVIDNLLKLLDAEEAGDDlsivelSLMTpWAKG--F--------SGDIRQ---TGKHSFVSRGNVE-----QVNTSTVRVTELP--VGK--WVEDykkfLWDLVGKKAIRSFSEHHSERD---VRFDISMTRsdlakyaeDAaencdagDSEALVKLLRLEAPLSTS---NMHAfnadgqLVKYE----TSEDVLRDFYGVRRKLYSKRKRH-LEQRQTK-EVLR-LSNRIRFIQEVStgslqKILRERIPKAELIDLLKEHGFAPASAFKEEAIDHMGDLGLAAVGREQGKAGDLDGSEDY--DYLLNTSLMSFTKEFADRLRKEHDTKQDKLQQLQA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A7TEE2(689-1157:1404) DNA topoisomerase 2 n=1 Tax=Vanderwaltozyma polyspora DSM 70294 RepID=A7TEE2_VANPO  E=2e-22 s/c=0.23 id=29% cov=47%
-------------------------------RSIPSVLDGFKPGQRKVLFCCFKINLTYEIK-------VGTLAAKvsektsYH-HGEESLQQTIVGLAQNFvgTNNIYLLKPAGSFGSraTGGKDAAAARYIHTQLNKVARSI----------FHPsddalfNYledDGSPIEPEwYLP-IIPMVLVNGAEGIGTGWSTNIPSFNPLDIIKNIRHLMN------DEVM-----------------DEMYPWYRGWKGvvekvddhRFRLYGKVE-----QVGPNVLEITEVP-----ARtWTSSIKEYLllglsgNEKTKPWIKDM-EEQHTNDIRFIITLTPEEMAKTKKIGVYDRFKLVSQVNLkNMVAFDaHGKIRKYdTVLDILTEFYYVRLEFYQKRKDYMSQKLQW---TVEKISFQVKFLKMIID--KEYTVSNKAKKIIMKELEGFGFPRINKDGKPHYGSVKIEEIEEGNEIEEGNA-NEEQDDTVhkpsdivgsydylLGMKLWDLT-MERyEKLRAQKQE--KEI-ELETLLKlSPKDLWN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C9S837(752-1259:1688) DNA topoisomerase 2 n=2 Tax=Sordariomycetes RepID=C9S837_VERA1   E=4e-22 s/c=0.21 id=28% cov=47%
-------------------------------RSIPSVLDGLKPGQRKVMFACFKRNLTKDQ------KVVelaGYVSEKaaYH-HGEMSLQQTIIGLAQNFvgSNNVNCLEPSGNFGSrlAGGSDAASPRYIHTRLSPFARKIFSVLDE------PNLevqmeDGKPIEPKVYAPIIPMVLCNGADGIGTGWSTSIPNYHPMEIVRAIKRRMGRLDSDDTEgkpfetMM-----PWF------RGWKGTPEPAEKDRYKF----NGIYETDDKTG--EIIIKELPIRMWTDDFKAKLEEVISGAKGPAwIKDYKEFNDHKNVNFVIQLDEkhykdiHKTHEGIMDRFKLNKQVATS---NLVAFDStGRIRKYeKVEDILEEFYVYRLDMYSARKKHWLGvyhsdyrklKNQARfiQEIIDGELIVSKK--------RKPVLVQELRDRKYEAFPKNDGKKQATTEEEDMDASDNEDDSVGGAADYDYLLSLP----IWSLTLERLERLNsaIMKKKGEHDALLAQ-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_P34534(604-1054:1054) Putative DNA topoisomerase 2, mitochondrial n=5 Tax=Caenorhabditis RepID=TOP2M_CAEEL  E=5e-22 s/c=0.24 id=25% cov=49%
-------------------------------RSIPSLIDGLKPSQRKILWTL--LNNMDESTEIKVSQLAGAVAHRqsYH-HGEESLVRTIIRMGQTFcgSSNLPLLQPIGQFGTRheGGNDAASARYIFTALAPTTRLLFpqadDDLLQKNVE-----EGMVVEPTWLCPIVPLILINGTEGIGTGWSTKIANRNPIDIIDMIRRKID--SISTE--------------------YEIPPFYEEFRGKLEVvtptkfisSGKIQlIRPERKNASTfSIEIVELPIGIWTSKYKEKLSKIVETLPVLEFSERHTE-KRVHFRITLDRKKSSRFLQKSNsDLLNYFKLRTSLTENRVLFDrNGELKEFgNISEIAAEFFEVRRDLYEKRLKIQKEECEAKLIYVENQLNFIEMVtNGTIEI------RSMGRNQLEEKLQEMGFRVDPMATIAKNSKKANYG-------------------YLLEMPVSRLTSDEMKRLEERKSRRRTELEAAES--ADWKSVW---RSELDKLAEAVGNNRKS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B7G2K9(708-1147:1165) DNA topoisomerase 2 (Fragment) n=1 Tax=Phaeodactylum tricornutum CCAP 1055/1 RepID=B7G2K9_PHATR  E=6e-22 s/c=0.25 id=27% cov=47%
-------------------------------RSIPSAIDGLKPSQRKVLYACFKRKL---KSEIKVAQLTGYCAEHtaYH-HGEASLQSTIIGMAQDFvgSNNINLLVPSGQFGTriMGGADAASPRYIYTYLAPIARSLFPEADDTLLSYLED-DGQQIEPEFYCPIIPLLVVNGCQGIGTGWSTFIPPHSANDVLEYILAKLDGA----ERLPKIHP--------FARGFQGRIEPDPNGNGYVSF-GRSSCISD-----RTILIDELPLRcwTNKYKGI--LLKMRDRGEVTSFVENHNTS---KVSFLVTLKSAQLARMTQAGLEKsfklKTNLQTT---NMHAFnKDGQickfdtaesiveaffPVRMQLYQdriaLLQSLLNYEASILR-------NKA--------GFIKAVTSGD--IDLTSGRRSKQETSKKLKEHGFLDSVELNAIKNENVLWKRRQFASEKGEGGSNLEPMN---FDYLLNMPLSSLTSEKIRELGEHAATKDKELEEMKS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q5CQG8(830-1409:1797) DNA topoisomerase 2 n=4 Tax=Apicomplexa RepID=Q5CQG8_CRYPV   E=8e-22 s/c=0.19 id=27% cov=53%
-------------------------------RSIPNLLDGLKPGQRKVLFATFKKKLNNE---LKVAQLAGYVAehSAYH-HGESSLQSTIVNMAQNFvgSNNLNLLEPCGQFGSRkeGGKDASAARYIFTKLSKWTRYIFPEAD----DPLLTYlydDGQQIEPLYYVPIIPMILVNGTDGIGTGWSSSVPNYNPKDIIMNLKRMLK------GEMMvpmtpwyKSFKGKIFPikqkskknsasnGGGnnnrkktainsfnngsnssILIGSqvdaedDDLQQIQRTnnmGNGIIeeTLELGANYETFGnwyKKNEETLVITELPvrrwtqdY----KEWLESTllpAPNADNDNIENswIIDYRDNSSHESVHITVRMRPEKLQQAEMEGIEKIFRLKSTLSTSNMTLFDHNSRIVryeTELDILKEFIPIRLEMYEKRKNYLLSKLNYEKCLLEQKILFLKlVIQGVIGLSNKSKETlvSDLKKNNIKSIKQVQELTQWVGVGGSNLAQNSISGSGIGGNPSFVDsgdnsmdyinfemnsfdyLESSQQDGILEstsysretnkgnelklfdyllsMPLWSLTK-EKMELLE--ADLIKKTEEYEKLLKtSIEEIWNTELDELLKVIEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C1E5N4(724-1168:1459) DNA topoisomerase 2 n=1 Tax=Micromonas sp. RCC299 RepID=C1E5N4_9CHLO   E=9e-22 s/c=0.24 id=24% cov=48%
-------------------------------RSIPSVVDGFKPSQRKVLFSCFKRKLKSD---IKVAQLSGYVSehSAYH-HGEASLASTIVGLAQDFvgSNNVNLLVPSGQFGTrlQGGKDHASPRYIFTRLAPICRVIFPECDDALLDYLDE-DGQVIEPEhYLP-ILPLVLVNGADGIGTGWSTSIPNFNPRDIV-ANIRRILDDECT--ERMH----PwyrNF--------KGTIEEEIVKGEIRYNITGKYEIVDE-----TTLVITELPlrsWTTDYKDFLENMLSPKEKNAQPFITDYKEHHTDTTVHFIVTMTPENMAKAQKDGIEKKFKLCAKVSTsNMHAFDEkgGITKYSSPEAIMEAFVplrldayARRRAMLIRQAEFELKRMSNKVR----FILAVVDGEMTIGRKKKSVLIEELEAAGYDKMPKTAKAAAAADAEPAESGLSDISEEGAPAPADGASY-----DYLLSMPLWNLTQEKVDELVEEQRVKTAEVEEL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_P11388(712-1184:1531) DNA topoisomerase 2-alpha n=47 Tax=Eukaryota RepID=TOP2A_HUMAN   E=1e-21 s/c=0.23 id=28% cov=45%
-------------------------------RSIPSMVDGLKPGQRKVLFTCFK---RNDKREVKVAQLAGSVaeMSSYH-HGEMSLMMTIINLAQNFvgSNNLNLLQPIGQFGTRlhGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFL--YDDNQRvEPEwYIP-IIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEE----------PLPMLPS-------------YKNFKGTIeelapnqyVISGEVAI-----LNSTTIEISELPVrtwtQTYKEQVLEPMLNG-TEKTPPLITDYREYHTDTTVKFVVKMteEKLAEAERVgLHKVFK---LQTSLTCNSMVLFDHVgclKKYDTVLDILRDFFELR-----------LKYYGLRKEWLLGMLGAesaklnnqarfiLEKIDG--KIIIENKPKKELIKVLIQRGYDSDPVKAwkeAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEKKDEL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B7XIW3(637-1078:1159) DNA topoisomerase 2 n=1 Tax=Enterocytozoon bieneusi H348 RepID=B7XIW3_ENTBH  E=1e-21 s/c=0.24 id=30% cov=43%
-------------------------------RSIPSVIDGLKPGQRKVIFSCFKRNL---KTEIKVAQLVGYVSEHsaYH-HGEASLAATIINLAHDFvgSNNINLLLPLGQFGSrlLGGKDSASPRYIFTNLNPLSRLIFHEhdipILESQIE-----DNLVIEPTYYVPIIPMVLVNGTDGIGTGWSTNIPNHNPLDLIKNIKRLLNNQEPE-----EMIP------------------YYRNYKGTItKINAGKYIscgKVFENINKKEINVVELPIGVwtqaYKEYLDQAIADNV-------IKSFKDYSTDKTIDILIHMN---------NNEFS-SKLTTSISTnNMVCFDrNGKIKKYhNTLEILKDFYEVRLEFYNKRKIYRLK------------LLA----DEL--------------NKLKNKVRFIEGVITGSIIITQRPLNEIILELERKEFTRYDNY-----EYLLDMKISSLTKEKINKLREEYNNKNIEYNELK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A7ANB1(678-1145:1437) DNA topoisomerase 2 n=3 Tax=Piroplasmida RepID=A7ANB1_BABBO   E=3e-21 s/c=0.23 id=27% cov=45%
-------------------------------RSIPSVVDGWKPGQRKVLFGCLKRNLVGEC---KVAQLTGYVAehSAYH-HGEASLQQTIINMAQNFvgSNNINVLEPCGQFGSRkeGGKDASAARYIFTKLNPITRLIFVEEDDNILEYQ-NEEGQTIEPMyYIPT-IPMVLVNGSEGIGTGFSSQIPNYNPLDIIDNLKRYLNNVDMKP-----MVP------------------WYHkfTG----------EIEPNDKGGFDClgnyqwldenglLEITELPirkwthdYRV----FLESLEQGVNGKE-PLILGFVDNSTHESVHFTLNVNPECIEEVInegVDKVFK---LRTSIATTNMTLFDANKKLkrySNELEIIRDFAAVRLATYEKRKTYLINNLKL-------LLRRISNQVRFIHMVVNEELVlfKKAKATLVAELRDLGFDSNTDILKGSEEPSTLNEPVTPSRRSGTQDAPGADYNYLLNMPLWSLTLEQVQKLNEEHAQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D0NA12(761-1190:1505) DNA topoisomerase 2 n=1 Tax=Phytophthora infestans T30-4 RepID=D0NA12_PHYIN  E=1e-20 s/c=0.24 id=27% cov=47%
-------------------------------RSIPSVMDGFKPSQRKVLFCCFKRNLRAE---LKVAQLAGYVSehSAYH-HGEASLQGCIVNMAQDFvgSNNIHLLSPIGQFGTrlMGGKDAASARYIFTNLEQLTRLIYHPLDNDCLKYLSE-DGQSIEPEwYIP-IIPMVLVNGSDGIGTGWSSSVPNYNPLDIIKGLRQMINGEEIAP--LTPWYRG--F-TG-HIVEKANSRG---TDTGNYIVQGLYEVTDDS-----TLVVSELPVkswtQTYKQFL----EGLLDAGTIKDFKE-----NHTDVKVLftITMEPKALSDVTKApgGIVKKFKLESSLSTSNMHLFDAAghiKKYENPKEIMAEFYGIRLEYYGRRKKAMLQKLQDQIKLLsnkARFVLAVVEGKLVV----NNRKKQELLEELMAEGYDQIVSKTKKKPDNEDSNESEDEEPNVADVSRGY-------DYLLSMKIWSLTKERVDKLRAELQE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B9PK68(793-1246:1688) DNA topoisomerase 2 n=3 Tax=Toxoplasma gondii RepID=B9PK68_TOXGO   E=5e-20 s/c=0.22 id=28% cov=48%
-------------------------------RSIPQLVDGWKPGQRKVLFACIKKNMKHELKVAQLAGYVSEVSA-YH-HGEASLQQTIVTMAQRFvgSNNLNFLEPVGQFGSRkeGGKDASAARYIFTRLAFYTRLVFHEADDPILEYE--YeEGQRIEPKMYVPVIPTVLINGSEGIGTGWSSFVPNYNPRDVIENLRRYIDG-----EEMQRMTP------------------WYRGFRGRIEENAAgTGFETIGlvrRCGEDSYEITELPikrwtqdY---KEWLEENLPT--AEKRDTLIADYRDCSSHEEIHFTVKVGEERVERPEREGLEKYFKLKSSLSITNLTLFDphGRVQRYaNELEIIKEFAPIRLEFYHRRKAYCLAMLEKARRILSNrlrFILAVVNGELIINNKR--------KKALIEELFSQGYDPMKEIEDAANAGIRAALKRDVIVDDEALAeggeeeeeivagCTAKHYDYLLGMPMWSLTLEKVEDLRGEMRQKELELEELR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q9Y8G8(741-1187:1587) DNA topoisomerase 2 n=79 Tax=cellular organisms RepID=TOP2_PENCH   E=2e-19 s/c=0.22 id=28% cov=36%
-------------------------------RSIPSVVDGLKPGQRKVLYTCFRRNL------KKDMKVVelaGHVSGTtaYQ-HGEGSLQQTIVGLAQTFvgSNNVNCLEPSGNFGSrLQGgaDCASA-RYIYTRLWPFARRVFHNHDDPLLTYNED-DGAKIEQEVYVPVVPMILINGADGIGTGWSSSTPNYNPEDIVENLKRMMDGEPLKP---MQ----PWF------RGFTG--EVTAVGQDRFKFSG-----IIKETGDKEVEITELPIRTWTQDFKDKLEDIIKAEKTPSfIKDYKDYNTHTKVHFVIQMDekhmKTAIAEG-LEEKFKLSKTMTT--TNLVAFDPERItKYASVEDIMKEFYAVRLKYYERRKQYQLSEMQKEL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D2XAH7(666-1085:1089) DNA topoisomerase II n=1 Tax=Marseillevirus RepID=D2XAH7_9VIRU   E=5e-19 s/c=0.24 id=31% cov=31%
-------------------------------RSIPSVFDGLKPSQRKVLYACFSSNIigKNKKKHVD--RLTGEVasVAGYH-HGEKSLTETIIGMAQDFVgcgNNVRLLNPDGSFGTrlRGGKDHSASRYLSSFVEKIARVVFppedDDLYEKVFE-----DNEYNEPInYIP-IIPLIVVNGACGIGTGHSTEIPPHNPLEVCHWIRCWLEEQE--TPKLSPWWKG--F------NGTTEVEED------KVKTFGVLE---KMSKTKWKIV--ETPVGLWTYDCKKHLESLETQK---HIKSFEDKYTDEKASFIINTTKDFIPTI------KNLKLSTTFSLrNMTALDEK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q8SS63(641-1107:1144) DNA topoisomerase 2 n=1 Tax=Encephalitozoon cuniculi RepID=Q8SS63_ENCCU  E=5e-19 s/c=0.21 id=27% cov=45%
--------TQISISDFVNKELILFSMADNI-RSIPSLVDGLKPGQRKVIFSCFKRNLRSE---IKVAQLVGYVSEQsaYH-HGEQSLCSTIVNLAQDFvgSNNINLLLPIGQFGSrlQGGKDAASPRYIFTSLSPLTRMIFNENDDAILNYL-NDDNFSIEPEFYVPIIPMVLVNGAEGIGTGWSTSIPNFNPVDVVENIRRMIRG-----EDPVEMVP------------------YYRNFRGTIEKIGEGKFQVSGIyEGDMDLEITELPVGTWTLNYKEFLESLVQA----GVA--RDFKEYH-------TEKTVSFTVKLSKPVSNLKLNSTITVnNMVCFDENlrikkyaTPQEI-LKEFygvrLRYYLI-RKENMLKVMREELEKLENK-----------------VRFIKE----------------VSMGELVISRRRKGEVIFDLESRGYARADDYEYLLS----MSILSLtveRIERLSN-EHAKRLSEYNQLMGK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_P08096(722-1191:1485) DNA topoisomerase 2 n=1 Tax=Schizosaccharomyces pombe RepID=TOP2_SCHPO  E=6e-19 s/c=0.21 id=28% cov=47%
---------QIPIDDFINRELIQFSMADNI-RSIPSVVDGLKPGQRKVVYYCFKRNLVHET---KVSRLAGYVASEtaYH-HGEVSMEQTIVNLAQNFvgSNNINLLMPNGQFGtrSEGGKNASASRYLNTALSPLARVLFNSNDDQLLNYQ-NDEGQWIEPEYYVPILPMVLVNGAEGIGTGWSTFIPNYNPKDITANLRHMLNGEPL---EIMT----P----------------WYRGFRGSITKVApdRYKISgIINQIGENKVEITELPIRFWTQDMKEYLeAGLVGTEKIrkfivdyeshhgegnvhfnvtlteAGMKEALNES--------LEVK------------FKLSRTQAT--SNMIAFDaSGRIKKYdSVEDILTEFYEVRLRTYQRRKEHMVNELEKRfdrfsnqarfIHmIIEGELVVSkkKKKDLIVEL-------KEKKFQPISKPKKGHLVDLEVENALAEEEQSGDVSQDEDSDAYNYLLS---------MPLWSLTYERYVELLKKKDEVMAE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C4R475(740-1176:1344) DNA topoisomerase 2 n=1 Tax=Pichia pastoris GS115 RepID=C4R475_PICPG   E=5e-18 s/c=0.22 id=29% cov=44%
-------------------------------RSIPSMLDGFKPSQRKILYGCYKRNLRSEIKVSQLAGYIGE-HSAYH-HGDQSLIQSIIGLAQDFvgSNNLNLLQPIGGFGSraQGGKDASAARY-----------IFTDLSKIT---KKNF--------------------SCQGIGTGWSTNIPPFNPVDIVANIRRLMDGQEME-----EMIP------------------WYRGWNGSItkisadKFRMEGNIEQIDD---ETIEITEIPaktWTINmKEFLLNGIAGSEKQK-----SWIKDMEEQHGMdlKFVITLTKEEMKKSLQMGLKERFKLITTINVgNMVAFDaaGKIKKYDNVNEIIEDYYHVRLDFYQRRKDHlaevlgnQLEKISSQARFVK---MIIENELRVnnrkrIELIeelqrlnfpKFSKDGKPIWQ--QVDQEEITEAEIKVEEEEEEEIDDENLLNKSVNIFASY-------DYLLGMPIWSLTRERYHKLLLQKAEKEDQLTELLKL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B0EP10(673-1123:1351) DNA topoisomerase 2 n=3 Tax=Entamoeba RepID=B0EP10_ENTDI   E=5e-18 s/c=0.21 id=29% cov=45%
-------------------------------RSIPSVVDGLKPSQRKVLWTclekniMKEL---------KVSQLSGLVSEKssYH-HGEVSLQATIVNMAQNFcgsnNVNWLLPSGQ--FGSRLGggkDQAAA-RYIYTRLSSISRYLCpkddDQILEYLVD-----EDRRIEPKYYCPIIPTVLVNGADGIGTGWSTAVSNYNPLDLVDNCRRYLNGEE------FKEMK-PWFRgwTGQLRKNKDGSgYDCY----------GKWR-----RLADDKIEITELPIQIWTDTYKQHLEKCIEAKIVKGYSEyhmV------NTVHFVIDLVQPMSDEDIWTNL----KLVSSVKTTNMHLFNSEYKITkyhTVLDILAEFCD------VRMKGYEERK-KAIIESMERQLMILSNkvrfIKMVIEgdLIINNRKKNELYKDLIKLGFDQIRDPKKANKSKPIGESEDAEIKEEDDDDEVGGY-----DYLLGMKIWTLTYEKAKKLMEDCDDLKTQI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_P06786(690-1149:1428) DNA topoisomerase 2 n=27 Tax=Fungi/Metazoa group RepID=TOP2_YEAST   E=2e-17 s/c=0.20 id=27% cov=48%
-------------------------------RSIPNVLDGFKPGQRKVLYGCFKKNLKSELKVAQLAPYVSECTA-YH-HGEQSLAQTIIGLAQNFvgSNNIYLLLPNGAFGTraTGGKDAAAARyiYTE--LNKLTRKIFHPADDPLYKYIQE-DEKTVEPEwYLP-ILPMILVNGAEGIGTGWSTYIPPFNPLEIIKNIRHLMNDEEL---EQMH----PWFRgwTGTI----EEIE--------PLRYRMYGRIEQIGDN---VLEITELP----ARTWTSTIKEYLllglsgNDKIKPWIKDMEEQHD-DNIKFIITLSPEEMAKTRKIGFYERFKLISPISlMNMVAFDpHGKIKKYNsVNEILSEFYYVRLEYYQKRKDHMSERLQWE---VEKYSFQVKFIKMIIEkeltvtnkprnaIIQELENLGFPRFNKEGKPYYGSPNDEIAEQINDVKGATSDEEDEESSHED----TENVIngpeelygtyEYLLGMRIWSLTKERYQKLLKQKQEKETELENLLKL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C3YYJ6(172-488:1181) Putative uncharacterized protein n=1 Tax=Branchiostoma floridae RepID=C3YYJ6_BRAFL  E=4e-17 s/c=0.29 id=30% cov=34%
-------------------------------RSIPSLVDGLKPGQRKVLFTCLK---RNDKREVKVAQLAGSVaeMSAYH-HGETSLMGTIINLAQNFvgSNNVNLLQPIGQFGTRihGGKDAASPRYIFTMLSTLARKLFNTFDEPMLNYQ--YDDNQKiEPEwYIP-LIPMVLVNGAEGIGTGWSTKVPNYDVREIINNMLRMIDGKD----------PLP-------------MNPSYKNFKGDIEEleenRFVANGEVAILDN-NTIEITELPIRTWTQNYKESVLEVMLhgtEKTPSMITDYKEYHTDTTVRFVVSMTEEQLMKAEAAGLHKVFKLQSNIASTNMVLfdHNGCLRTYNsVHQILQEFFDLR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_P30182(700-1144:1473) DNA topoisomerase 2 n=6 Tax=Eukaryota RepID=TOP2_ARATH   E=3e-16 s/c=0.20 id=27% cov=45%
-------------------------------RSIPSMVDGLKPGQRKILFV----------AFKKIARkemkvaqLVGYVslLSAYH-HGEQSLASAIIGMAQDYvgSNNINLLLPNGQFGtrtSGGKDSASA-RYIFTKLSPVTRILFPKDDDLLLD-YLNEDGQRIEPTwYMP-IIPTVLVNGAEGIGTGWSTFIPNYNPREIV-ANVRRLLNGESMV------------PMDPWYRGFKGTIEktASKEGGCTYTITGLYE-EVDE----TTIRITELP----IRRWNDDYKNFLQSLKTDngapffqDVKAYNDE-------------KSVDFDLILseeNMLaarqegfLKKFKLTTTIATSNMHLFDKkgvikkyvTPEQI-LEEFFDlrfEYYEKRKETVVKNMEIELLKLENKAR----FILAVLSGEIIVNKRKKADIVEDLRQKGFTpfpRKAESVEAAIAGAVDDDAAEEPEEILVDPESSSSYIPGSEY--DYLLAMAIASLT-----------------IEKVEELLADRDKMI----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_O24308(679-1066:1462) DNA topoisomerase 2 n=3 Tax=fabids RepID=TOP2_PEA   E=6e-16 s/c=0.23 id=30% cov=26%
----------------------------------------------------------------------------YH-HGEQSLASTIIGMAQDFvgSNNINLLKPNGQFGTcnLGGKDHASARyiYTE--LSPVTRCLFHEHDDKLLEYL-NEDGKSIEPNwYMP-IIPLVLVNGSEGIGTGWSSYIPNYNPREIIANVRRLLNG-----EELVPMDP------------------WYKGFRGTIEKSAKeggyivngTVTEIDEQTFR----ITELP--IRKwtqdyKQFLESITDGAPNVKDPLIEDFRQNGDDAIVDIEIKMKPEKIATILQEGLFKKFKLTSTISTSNMHLFD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A8PTE9(644-1116:1376) DNA topoisomerase 2 n=1 Tax=Malassezia globosa CBS 7966 RepID=A8PTE9_MALGO  E=1e-15 s/c=0.19 id=29% cov=48%
------RIRNIPISDFINKELILFSMADNI-RSIPSVVDGLKPGQRKVIFSCFKRKLKTEikvhqlQGYVSehSA---------YH-HGDQALTMTIVGLAQDFcgSNNVNLLMPNGQFGsrSMGGKDAASARYIFTAVPRITRLMFHADDEPLLNYLED-DGQSIEPEWYAPVVPQVLLNGAEGIGTGWSTFVPNYNPREVVDNLRRRMAGE--------EYVPmnpwyrG--F--------VGGIEPA---GPERFRVTGIARQLDERTWE-----ITELPVrvwtMTYKEWLEERV---VGSDKTPAV--LReykeyhtDTS----VHFVVELNPRGMEEIERvgpDTFFKLsTMLSTS---NMV-LFNpegkikkyATPQ-----EILEDFYFVRLGFYQRRKEHLVDQLKlvyDR----------LSNQARFVSMIiaRELSVSNKKKAAIVEELRQLKFQAFPKVEAKAKSVTEEAVEDQEEPDEPANSNTDY--DYLLSMAIYSLTQERVERLLKERDHTE---TELKILLGrSPQNLWD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_O41065(649-1050:1061) A583L protein n=7 Tax=Chlorovirus RepID=O41065_PBCV1   E=3e-15 s/c=0.22 id=32% cov=43%
-------------------------------RSIPSVVDGFKPSQRKVLYCAFKRNLTSD---VKVAQFSGYVAehSAYH-HGEVSLQGTIVNLAQDYvgsnNINWLLPEGQ--FGSrLQGgkDHASA-RYIFTKLNPKTRQVFVDTDDNLLKYL--YDDGDKiEPECYVPIIPSILVNGSSGIGTGSSTNIPSYNPKDIVDNVKRLI-----SGEDLVEMKP------------------WYKGFKGKImeTSPGVYVTKGLYMPNGKTIVVSELP--VGKwtHDYKEHLDGLL-EKKI--ISYFREKhSDTD---VLFEIDFVGNPNIdIL-------KLETTIrSTNMHAFDpsGKIKKYDTPLDIIRDWFEVRKDLYVKRKAYLLEDLTHRTNIAQNkhrFITMVNN-DEII-----------------------------INKKHESVISAELEKLNFYKVDGKY-------DYLLNMRissltLERATELEREavKLNKELDDLSKTTE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_P05653(8-806:821) DNA gyrase subunit A n=10 Tax=cellular organisms RepID=GYRA_BACSU   E=0 s/c=1.36 id=55% cov=91%
------QVREINISQEMRTSFLDYAMSVIVSRALPDVRDGLKPVHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYMLVDGHGNFGSVDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVMPSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIPELMEVIPGPDFPTAGQILGRSGIRKAYESGRGSITIRAKAEIE-QTSSGKERIIVTELPYQVNKAKLIEKIADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGINLLALVDGQPKVLTLKQCLEHYLDHQKVVIRRRTAYELRKAEARAHILEGLRVALDHLDAVISLIRNSQTAEIARTGLIEQ----------------------------------FSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLVKLIAELKDILANEYKVLEIIREELTEIKERFNDERRTEIVTSGLEtIEDEDLIERENIVVTLTHNGYVKRLPASTYRSQKRGGKGVQGMGTNEDDFVEHLISTSTHDTILFFSNKGKVYRAKGYEIPEYGRTAKGIPIINLLEVEKGEWINAIIPVTEFNAELYLFFTTKHGVSKRTSLSQFANIRNNGLIALSLREDDELMGVRLTDGTKQIIIGTKNGLLIRFPETDVREMGRTAAGVKGITLTDDDVVVGMEILEEESHVLIVTEKGYGKRTPAEEYRTQSRGGKGLKTAKITENNGQLVAVKATKGEEDLMIITASGVLIRMDINDISITGRVTQGVRLIRMAEEEHVATVALV------------------------------------
>UniRef50_B8CZP0(3-816:816) DNA gyrase, A subunit n=5 Tax=Bacteria RepID=B8CZP0_HALOH   E=0 s/c=1.32 id=53% cov=92%
------KVLEVDIENEMKGAYLDYAMSVIVSRALPDVRDGLKPVQRRILYALHDLGITPNKPHKKSARVVGEVLGKYHPHGDTAVYDTMVRMAQEFSFRYPLVDGHGNFGSIDGDSAAAMRYTEVRMARLTTELLRDIDKNTVDFAPNFDESLEEPEVLPARLPNLLMNGVSGIAVGMSTNIPPHNLGEVIDGVVALIDNPDLEVKDLMKIIKGPDFPTGGIIMGKDKIYQAYKTGRGRLKVRGKARIEED-KNGKSKIIITEIPYQVNKARLVEKIANLVRDEKITGISDLRDESDRRGLRIVIELKKGTVPKVILNRLYKYTQLQVTYGVIMLALVDGMPRVLTLKELLNHYLEHQKEVVTRRTKYQLDKAEARAHILEGLRIALANIDDIVQLIREAPDVDTARRGLIEN----------------------------------FNLTEKQAEAILRMRLQRLTGLERDKIEAEYKELKEKIAYYRSILADEGKLLGIIKDELLELKEKFQDERRTEISIQAVDLDVEDLIPEEQVVITLTHHGYIKRMPIDIYRSQRRGGKGIIGINTKEEDFVEHVFTTSTHHYFLFFTNKGKVYRLRVFEIPQASRQARGTAIVNLLELEEEERITTVIPIREFDEERYLVMVTRNGMIKKTPLAEYES-RYTGLIGLTLRDEDELIDVKYTDGNQSVIIVTHRGKAIHFKENEVRSMGRTAMGVKAITLEDGDYVVGMGVDSEGDDLLVITEKGYGKRTPLEEYRLQSRGGKGLITANITEKNGNLAGVKVVREDHDLILITSEGIIIRTRVEGISRLGRNTLGVKVIRLEEGDRVVSLARISP--EEKDIEEMD-----------------------
>UniRef50_D1B8A6(8-816:816) DNA gyrase, A subunit n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B8A6_THEAS  E=0 s/c=1.30 id=47% cov=92%
-SDLFQKVIPLPLEEEIKHSYIDYAMSVIVGRALPDARDGLKPVQRRILYAMRELGLRHSQPFKKSARVVGETMGKYHPHGDAAIYETMVRMSQDFSMRYPLVDGQGNFGSIDGDPPAAMRYTEARLHSLGEEMLADIDEDTVDWLPNFDESLEEPAVLPSRIPNLLVNGSTGIAVGMATNMPPHNLREVVDACCTLLDNPDVEVGELMTHVPGPDFPTGGVIMGRDGIIDAYTTGRGKIVVRGCAEIE-DAKRGKKAIVITQIPYMVNKSNLIETIVKGVQAGQLDGITDVRDESNREGIRLVLELHRDSDPHLVLRQLYSRTQLQTTFGVINLALVDGRPVELNLKGLLQIFIDHRRMVVRRRTQYRLRKAEERAHILEGLVKALDMIDMVIALIRSSEDPLVAKGRLVEE----------------------------------LGFTEAQAQAILDMRLQRLTSLEKHKLQEELAELMAQIARYRLILGDPAELDSVVREELLEVKRAYGDERRTVIEDSVDDVSYEDLIPETEVVVAMTRDGFIRRMPLQDYRCQARGGKGVKGAAVKGEDEVSLVAVTTTHRSLYLFTDRGRVFSLKCLAIPE-PKSGRGKHVSTFISLDEGESVVT-FRDSALEGARFVFLVTKMGLAKRLPVGELEGITRAGRRILGLEEDDTIARVRFTGGEDQLLLTTAKGQTLRVSETEFRPQGRAAKGVRGIKLDPDDLVVGCDVIMPGRQVLFISQLGMGKRTRYEEFTVHHRGGMGVRAMRLGERTGHLVGAWGVADDDEIMVITSRGRVVRFSARDVSSLSRSAMGLTLVRLDEGDQVADVTVIRCSMEE------------------------------
>UniRef50_D1N7T7(1-873:885) DNA gyrase, A subunit n=1 Tax=Victivallis vadensis ATCC BAA-548 RepID=D1N7T7_9BACT  E=0 s/c=1.14 id=46% cov=96%
MSDLGTRDFQVNIEDIMHTAYLQYSLSVNVGRAIPDVRDGLKPVNRRILYAMRQLGLGKSHATVKCARVVGEVMGKYHPHGDAAIYDALVRLAQDFSMRNPLIEGQGNFGNIDGDPAAASRYTECRMERLAEELLADIEKDTVNMIPNFDESETEPEVLPARYPQLLVNGTTGIGVGMATSIPPHNLGEVIDATICLLDNPKATVDELMEYLPGPDFPTGAIIRGRYSMRQFYQTGHGSIKIRAKADI--IEKDGREQIIVSEIPYAICKEQLVKKIAELVNDKRITGISGLRDESSkRTGMRIVIEIKRGAMGSVVLNQLFAHTMLETTIGCTMLVVDHNRPRTMNLVQVLQAYIDHRLEVIVRRTLFELKKAQARAHILEGLMKALANINDVVQIIRESRSRQDAAANLIAR----------------------------------FEFTQIQVDAILDMRLHQLTGLAIETLTAEYEELKKRIEYLTALAASREMQLGVIKDELKEIREKYADPRRTEITIDDTDLNIADLIPRHSCVITVSNTGYIKRVPADTYRTQHRGGKGIIGMETKEEDHVEHLFNADSHDIIFFFTDRGFMYWLNVYEIPEGSRTGKGRAITNMIKVEPGEKICAMLTVRQeefDDPNKYIVMASRRGFIKKSELALFKNLRRVGLRALVIEEDDDLIGAGISENGNEILLSTKFGMACLFDQDDdqIRPMGRTARGVTGMRFKiEGDSVVSLEIIREhlyeepaedeegeevevevdvdeempvvgsGPEVLVVTDGGMGKRSYVSTYRKTKRGAKGVVNIKLREGE-TVLSVVQITEEDEILLTTERGQLVRIPAHEIRRVGRASYGVRIMNLNSGDRITGVAKLVE-VDVPKSPATEEGGAESSETPA-EVPVAEIPATE
>UniRef50_D1Y742(8-808:871) DNA gyrase, A subunit n=1 Tax=Pyramidobacter piscolens W5455 RepID=D1Y742_9BACT  E=0 s/c=1.21 id=47% cov=91%
------RVIPNPLVPEIKRSYLDYAMSVIVGRALPDARDGLKPVQRRVLYGMLGLGIRHNQAYKKSARVVGEVMGKYHPHGDASIYDTMVRLAQPWNLRYPLVDGQGNFGSVDGDGAAAMRYTEARFAELGELMLQDIDEDTVDWGPNFDESLKEPLTLPSLVPNLLVNGSTGIAVGMATNMPPHNLGEVIDALCCLIDHPEAELGELMNYLPGPDFPTGGIIMGREGIVDAYRTGRGKIIVRGRCVVEEGKR--RTSVVITEIPYMVNKTTLIEGIAKCVQEHTIDGVSDLRDESDRQGLRIVLDLNRDGDPELVQRQLYNRTLMQSTFGVINLTLVDQRPVELGLKSMLEVFLDYRRDVVRRRTAFRLAKAQEREHIIEGLCRALDMIDEVIRIIRGAQTAEEASHGLTEQ----------------------------------LQFSEKQAQAILDMRLQRLTGLERDKLTAEMAQLLADIARYQEILADAKTLDGVIRDELAELRHKFGDKRRTEIQlhVESTSDSYEDLMPEENIVITLSKDGYLRRSLLKDYNVQNRGGKGRRGANLHEEDQVAGMVVTTTHNDVLLFTSRGRVFAIKGHMVPE-TKSGKGRKVEQFISLSEGETVVEIL--GRFPDNcSTVVLITRRGIAKRMDKSELQNLTRAGRQIMTLDDGDDIARIRCTNGLDDLFLVSAMGRGLRISEDEIRTMGRSARGVKAMKLGKDDEIISCEVIAGDSRILLVSQRGIGKITSYDEFSVHHRATGGQRAMRIGDRTGRLAVANTVFPDDEVALMTAGGNIIRLAVDSIPQLGRDAAGSILIRPENGDEVANVSLI------------------------------------
>UniRef50_B8FW91(1-807:808) DNA gyrase, A subunit n=2 Tax=Desulfitobacterium hafniense RepID=B8FW91_DESHD  E=0 s/c=1.15 id=43% cov=91%
MSIPEENITQRSLEEVLPESYLGYSKHVILQRAVPDVRDGLKPVHRRIIYAMDELGMTPDKPYSKSARLVGDCMGKYHPHGDSSIYDAAVRMAQPWATRYPLIDGQGNFGSIDGDGAAAMRYTEMRMTHLSQLMTQDIEKDVIPFKPNYDQREKEPIVLPSPFPNLLVNGGSGIAVGMASNIPPHNLREVVAALILQIDNPHVTLEQLMEKVKGPDFPTGGLIIGSQGFTEAYRSGRGKVTMRGKAIIES-GKNGKSLIVITEIPFQVSKSTLAAKIEAQSENGKIEGISEVRDESDREGIRLVVECKKDADPKRILKLLYKYTQLQETFGIINLVIsEEGTPRVLGLKEINHSYLQHRREVVLRRTEYELAKAKARAHILEGLVIAINNLDEVLQIIRSSKTPALAKAGLITR----------------------------------FEFSEVQAQAILDMKLQHLTNLELDGIRKEYAEILKLIAELESILADINKVYTIIKNELKQIADQYGDERRTLILPEDvgDEVDYSAFeEPEKPMEVLLTRKGFIKQIPTPTRRSQ----INAIAFAFKDGDVLLEHVSCTSKDTLYFFTHSGKYYDAKAKLVAEAGAKEKGRAVNNLFPLPEEERIVAMVSLREEKEGQYFVFVTKDGQVMRSPVKDFLNARTA--EAMGLKEQDEIVKVFLSAGEGELFLASLQGQAIRFAEAEVNPMGRKSRGVKGMTLNEGDYVVDALLIQPGadgetGDLITVTEQGYVKRTSLEEYKPQGRAGRGIAIAKIdAEKTGYLVSLIQVGPKEDklLHIIQAGGAVTGVEAQSLKRESRVKSGAGLVNVIINDYIVHV---------------------------------------
>UniRef50_O51396(5-810:810) DNA gyrase subunit A n=18 Tax=Borrelia burgdorferi group RepID=GYRA_BORBU  E=0 s/c=1.14 id=42% cov=91%
-----EQILNVRIEDEIKTSYLNYAMSVIVSRALPDVRDGLKPVHRRILYSMYEMGLRSDKAFKKAGRIVGDVLGKYHPHGDQSIYDALVRLAQDFSLRYPVIRGQGNFGSIDGDPPAAMRYTEAKMEKITEYIVKDIDKETVNFKSNYDDSLSEPEIMPSSFPFLLVNGSSGIAVGMATNMAPHNLREICDAIVYMLDNENASIFDLLKIVKGPDFPTFGEIVYNDNLIKAYKTGKGSVVIRARYHIE-ERAEDRNAIIVTEIPYTVNKSALLMKVALLAKEEKLEGLLDIRDESDREGIRIVLEVKRGFDPHVIMNLLYEYTEFKKHFSINNLALVNGIPKQLNLEELLFEFIEHRKNIIERRIEFDLRKAKEKAHVLEGLNIALNNIDEVIKIIKSSKLAKDARERLVSN----------------------------------FGLSEIQANSVLDMRLQKLTALEIFKLEEELNILLSLIKDYEDILLNPVRIINIIREETINLGLKFGDERRTKIIYDEEvlKTSMSDLMQKENIVVMLTKKGFLKRLSQNEYKLQGTGGKGLSSFDLNDGDEIVIALCVNTHDYLFMISNEGKLYLINAYEIKDSSRASKGQNISELINLGDQEEILTIKNSKDLTDDAYLLLTTASGKIARFESTDFKAVKSRGVIVIKLNDKDFVTSAEIVFKDEKVICLSKKGSAFIFNSRDVRLTNRGTQGVCGMKLKEGDLFVKVLSVKENPYLLIVSENGYGKRLNMSKISELKRGATGYTSYKKSdKKAGSVVDAIAVSEDDEILLVSKRSKALRTVAGKVSEQGKDARGIQVLFL-DNDSLVSVSK-------------------------------------
>UniRef50_UPI0001B9EC7F(2-818:819) DNA topoisomerase IV, A subunit n=1 Tax=Geobacillus sp. Y412MC10 RepID=UPI0001B9EC7F  E=0 s/c=1.12 id=43% cov=92%
--SLSEQFLPAFLEEVVGDRFGRYSKYIIQDRAIPDVRDGLKPVQRRILYAMYDSGNTPDKPYRKSAKTVGDVMGNYHPHGDSSIYEGMVRMAQPWKMGHVLVDGHGNWGSQDDDPAAAMRYTEARLSPIAMELLRDIEKRTVLFKDNFDNTAKEPVVLPSRYPNLLVNGASGISAGFATEIPPHNLREVIDACIAVMQKPEIELDEIMTFIKGPDFPTGGIIMGGEGILDAYRTGKGRVYLRSKTVIES-LRGGKQQIVITEIPYQVVKSRLVTAMENIRLEKKVEGIAEVRDESGREGLRIVVELKKDADANGILAYLFKKTDLQITYNFNMVAIVNKTPQQLGLKAMLSAYIDHQREVVTHRTQFELEKAEDRAHVLEGLVKALNILDEVIAAIKASKNRQDAQNNLQ----------------------------------WMFGFTERQADSILTLQLYRLTNLEIHSLQKELDELTKKIEGLRAILDSDKKLIGVIRKELIEIREKYGIDRRSVIQEEVEEIkvNLEVLVNAEDVLVTLSNEGYIKRTSMLSF---TRSGGELESSGVKEGDYITRLFEVNTLENLLIFTSRGQYFLLPVHQVPEYKWKDAGTAIVNVIQVPKEDHIVSVIPVSNFDEaGKSLVFVSRKGQVKRTDLKEYVTKRSGAVAAAKVAAEDSIIQVVMSDSNKDIVLISKEGMSIRFNEQEVNAMGRVSGGVRGIQLRDGDEVVAALWVeNDEGEILTITDLGYGKRSLLLDYPAQSRGGKGMATFEFKEGKRvkpngsAIVGAFYCREPLQINAYSEDGQAFPIHTEKVPIMERKSIGKLLADVGKNGQIVDLVSLPH----------------------------------
>UniRef50_Q2JQA2(1-805:819) Type II DNA topoisomerase, A subunit n=2 Tax=Chroococcales RepID=Q2JQA2_SYNJB  E=0 s/c=1.14 id=41% cov=89%
----------TDLQGEMQRSYLEYAMSVIVGRALPDVRDGLKPVHRRILYAMHELGLTPDRPYRKCARVVGDVLGKYHPHGDQAVYDALVRMVQDFSSRYPLVAGHGNFGSVDDDPPAAMRYTECRLAELSHtALLEQVSEEIVDFMPNFDGSQAEPTVLPARLPILLLNGSSGIAVGMATNIPPHNLGEVVDGLLALIDHPDLSPEELLRWIPGPDFPTGGQILDTQGIRAAYLTGRGSITLRGVARFEEiqpgKGRHRRPALVISEFPYQVNKAAWIEKVAELANQDRISGIADLRDESDRSGIRVVVELKREANPQAVLQQLYKLTPLQSNFGAILLALVNGEPRQLSLKEILQHFLQFREATLNRMFRAELQQVQRKAEEVAGMLLALADLEGVIELLRQAPDGTTAKAQLQTR----------------------------------LGCTPQQAETILAMPLRRLTGLERERLHQEHAQLQTRIEELQGLLSDRRKLLNYLKKELRHLKKTFGDPRRTQIlsaselEAEVAQIPSGEETEETHFLLQFTRKGYVRRLPLPS-----RRSRSNPAQRELGEDVLVGLECVTLEQEILVLTAGGKAFTLPIAGIPLSTGSSRGVPLVTLLP--NPEPIVATFTLDPDPGKASLVVLSRQGRIKRLALAELMGLTQRGSTVLKLKEGDELGWAALWDPDHQgysVVLATSGGRVLRLDVQQIPLMGRAAMGSPALRLGRTERIVGMALVPSQGILVLASRLGYLKRLSLEEIPILERGQVGAPAFHFSDRGDVLVGLVGLPPELErpshlqLDVITESEQVYSFSPAEIPLQSRSGGGSLLVK---GERV------------------------------------------
>UniRef50_B9ZQ27(16-823:823) DNA gyrase, A subunit n=1 Tax=Thioalkalivibrio sp. K90mix RepID=B9ZQ27_9GAMM  E=0 s/c=1.11 id=43% cov=91%
----------LEIGNVMRSSFADYAMSVITDRALPDARDGLKPVHRRILYSMHQLGITHMVAHKKSARVVGDVLGKYHPHGDSACYDSAVRMAQHWAMRHPLIDGQGNFGSIDGDNAAAMRYTEMRLSKLGTRLFADIQKNTVDFRDNFDGTEREPEVLPLTYPNLLVNGSEGIAVGMATSVPPHNLRETADAFLAWLDNPEITTREIAQHMPGPDFPTGGILHDLDGYIQALDTGRGAVKLRSQWTVE-DRPRGGSRLVIDQIPYAVNKAKLVEQIAELVREKKIEGVADLRDESNKKGIRIVLEIKREFEAEAIAFQLVTMTQLETSVRYNIMALVGQTPMQLGVRDLFEHFRAHRIEVIQRRTQFDLDRALDRLHILEGLLMALDRLDETIATIRASADADEARGGLI----------------------------------DLLGIDVTQAQAILDMKLQKLTGLQIQDIRDEHDRLTAEVADLRDILARSERQVEIMRTELLDLCDQHANERCTEIDTSLSKVSAADLIPEEDVMLIGTQQGYLKRIAAKDMNRQNRGTKGRSIMSVGEDDLVTTFHAGHSHDTLIALTDSGQVHAIKAYDIPDTGLGNKGRHYRNVFEGVEG-NVVAMLTVDGLESvTHSLVIFTAQGLVKRTPLSAYSNaTRRGGIQGISLVEGDSIVCARVSKDEpnESVIVAADNAKAIRFGMEEARAIGRTSRGVRAMNLSEDARVVAGDIIHADDlekaHLMVVSEKGLGKATPASEFRLQSRGGKGVTSYTPNKRSGPVVAATVLFEGADVVLFNDQGGANRIAGSDVPHNGRATTGSAIIR---NGSVRNVLAVPPPVEEDQ----------------------------
>UniRef50_Q114B8(5-870:873) DNA topoisomerase IV subunit A n=4 Tax=Cyanobacteria RepID=Q114B8_TRIEI  E=0 s/c=1.02 id=40% cov=92%
LNLLSGKVITTSLHTEMQQSYLEYAMSVIVGRALPDVRDGQKPVHRRIIYAMHELGLTPDRPFRKCARVVGDVLGKYHPHGDQAVYDAMVRMIQNFSSRYPLLDGHGNFGSIDNDPAAAMRYTESRLASIGNEgLLTQISEAIVDFTNNFDGSQQEPKVLPAQLPFLLLNGSSGIAVGMATNVPPHNLGEVVDGLIALIDNPNISDQKLFELIPGPDFPTGGEIVSTDGIIDTYTKGRGSIPMRGVATIEQvptgRGRRTKTAIVVTELPFQVNKAGWIEKTADLVNAGKIEGIADLRDESDRSGIRVVIELKREADPSVVLHHLYRNTDLLSKFGAIMLALVNGQPQQLSLRTLLQEFLNFREETLTRHYTHELQIAQARSHIVAGLLTALKELDRVIDILRNAPDGNTAKVSFQE----------------------------------SLGLSENQADAILAMPMRRLTGLEKQKLEEEHEQLMGKIQELENLLGDRHQLLKALKKELRTLKRKYNDPRRTRIIDQIKLKNADDFAsisqqkkyleagnkeidiktkgrviksknitvkspiltleaappPTEKVVIEFSHRGYVRRIPAKGFEKYKIDKKSHITME-NSEDFTTNIIEATTDKTLVLLTRTGKAYPLKVNNIPSASNRStirnenKGVPLVTLLPPSAtkeitdarKEIIIGQFILNEAKENKDLIMLTQNGKIKRLCLSDLSDMRNRGVTVIKLKEDDELRYVSLGKTGEQVVLATSGGRLLRLQIDDekLPLMGRAAQGSQATRLRKQEELVGCVTLDIGSNLLLVSQHSYGKQIPVTALRVANRGGIGQNVFQFTRQDDILAGIVASSSNVLVQVLTTDGRVFGMIADRVKVDQQDDHGHRLLKLGAKEKIIKV---------------------------------------
>UniRef50_B7KIH9(12-845:848) DNA topoisomerase (ATP-hydrolyzing) n=6 Tax=Cyanobacteria RepID=B7KIH9_CYAP7  E=0 s/c=1.05 id=39% cov=90%
------QIIPTALHQEMERSYLEYAMSVIVGRALPDVRDGMKPVHRRIVYAMHELGLTADRPYRKCARVVGDVLGKYHPHGDQAVYDALVRMVQEFSSRYPLLAGHGNFGSVDNDPPAAMRYTETRLAPIGQEaVLGNISEAIVDFTNNFDNSQQEPVVLPAQLPILLLNGCSGIAVGMATNIPPHNLGEIVDGLIALIDRPQLKDEQLWEIIPGPDFPTGGKIIDTEGIKEAYRTGKGIIPVQGVTHVETISLEGrrpkeRTAIVVTELPYQVNKSGWIEKVADLVNQGRLEGIADIRDESDRQGMRVVIELKREFKTKKVLEDLYKQTALQSNFGVILLALVDNKPCQLSLRELLEEFLNFREQTLTRQYRHELTQAQTRLHLLEGLLIALRNLDQVINILRNAPDGTTAKQKFQEE----------------------------------LTISEEQADSILAMPMRRLTGLEQQKLQTEYEDLQQRINQLQVLLNDRIELMKSLKKDLRALKRKFGDERRTRIVSSAPTASKSEEkkgnpstppqpsktttpskssepkakdssslslftpqPPPKDAVLTITEQGYIYWQSAAEFNSISSIKKGT--------DFPIYTQRIQQQDSLIVITDQGKAYPVSGSEIP--PQESQPCSLLNLLPnsvQKNSQKIASYFLFPQQKNLSELILLTGQGRIKRLSMSELEQIGNRGLSLIKLKDDDRLGYLSLTSESHEVAIATNGGRVLRLttRDEQIPLMGRNAQGNQALRLRYGENIVGCVTPKIDDNLLLITQSGYGKRIPVNSLRITKLGEIGTMALQFSSKTDNLAGMILAKPKKEVILVTNQERRLIIPIDSVGIWGKDGVGDQVVKLKPQESI------------------------------------------
>UniRef50_Q8CSN8(1-797:800) DNA topoisomerase 4 subunit A n=77 Tax=Bacteria RepID=PARC_STAES   E=0 s/c=1.08 id=40% cov=86%
---MSEIIQDLSLEDVIGDRFGRYSKYIIQERALPDVRDGLKPVQRRILFAMYSSGNTYDKNFRKSAKTVGDVIGQYHPHGDSSVYDAMVRLSQDWKLRHVLIEMHGNNGSIDNDPPAAMRYTEAKLSQLSEELLRDINKETVSFIPNYDDTTLEPMVLPARFPNLLINGSTGISSGYATDIPPHNLAEVIQGTLKYIDQPDITINQLMKYIKGPDFPTGGIIQGIEGIKKAYETGKGKVVVRSRVD-EEPLRSGRKQLIVTEIPYEVNKSSLVKKIDELRADKKVDGIVEVRDETDRTGLRIAIELKKDANSESIKNYLYKNSDLQISYNFNMVAISEGRPKLMGLREIIESYLNHQIEVVTNRTRYDLEQAEKRMHIVEGLMKALSILDEVIALIRNSKNKKDAKDNLVAE----------------------------------YDFTEAQAEAIVMLQLYRLTNTDIEALKKEHEELEALIKELRNILDNHEALLAVIKDELNEIKKKFKVDRLSTIEAEISEikIDKEVMVPSEEVILSLTQHGYIKRTSTRSFNAS-----GVTEIGLKDGDRLLKHESVNTQDTVLVFTNKGRYLFIPVHKLADIRWKELGQHISQIVPIDEDEEVVNVYNEKDFKNEAFYIMATKNGMIKKSSASQFKTTRfNKPLINMKVKDKDELINVVRLESDQLITVLTHKGMSLTYSTNELSDTGLRAAGVKSINLKDEDYVVMTEDVNDSDSIIMVTQRGAMKRIDFNVLQEAKRAQRGITLLKELKKKPHrIVAGAVVKEN-----------------------------------------------------------------------------------
>UniRef50_P72525(2-810:823) DNA topoisomerase 4 subunit A n=182 Tax=Firmicutes RepID=PARC_STRPN   E=0 s/c=1.06 id=39% cov=90%
-----SNIQNMSLEDIMGERFGRYSKYIIQDRALPDIRDGLKPVQRRILYSMNKDSNTFDKSYRKSAKSVGNIMGNFHPHGDSSIYDAMVRMSQNWKNREILVEMHGNNGSMDGDPPAAMRYTEARLSEIAGYLLQDIEKKTVPFAWNFDDTEKEPTVLPAAFPNLLVNGSTGISAGYATDIPPHNLAEVIDAAVYMIDHPTAKIDKLMEFLPGPDFPTGAIIQGRDEIKKAYETGKGRVVVRSKTEIE-KLKGGKEQIVIIEIPYEINKANLVKKIDDVRVNNKVAGIAEVRDESDRDGLRIAIELKKDANTELVLNYLFKYTDLQINYNFNMVAIDNFTPRQVGIVPILSSYIAHRREVILARSRFDKEKAEKRLHIVEGLIRVISILDEVIALIRASENKADAKENLKV----------------------------------SYDFTEEQAEAIVTLQLYRLTNTDVVVLQEEEAELREKIAMLAAIIGDERTMYNLMKKELREVKKKFATPRLSSLEDtaKAIEIDTASLIAEEDTYVSVTKAGYIKRTSPRSFAASTLEEIGK-----RDDDRLIFVQSAKTTQHLLMFTSLGNVIYRPIHELADIRWKDIGEHLSQTItNFETNEEILYVEVLDQFDDATTYFAVTRLGQIKRVERKEFTPWrtyRSKSVKYAKLKDDtDQIVAVAPIK-LDDVVLVSQNGYALRFNIEEVPVVGAKAAGVKAMNLKEDDVLQSGFICNTSSFYLL-TQRGSLKRVSIEEILATSRAKRGLQVLRELKNKPHrvfLAGAVAeqgfvgdffsteVDVNDQtLLVQSNKGTIYESRLQDLNLSERTSNGSFISDTISDEEV------------------------------------------
>UniRef50_D2REE0(3-731:738) DNA gyrase, A subunit n=3 Tax=Archaeoglobaceae RepID=D2REE0_ARCPR   E=0 s/c=1.15 id=46% cov=83%
-----------DIAEELKDAYLDYAMSVIVGRALPDVRDGLKPVQRRILYAMYEMGLTHDKPHVKCARVVGHVLGHYHPHGDAPVYEALVRMAQDFSMRYPLIDGQGNFGSIDGDEPAAMRYTECRLTEIAEKMLEDIDKNTVDFQPNFDASKQEPVVLPAKIPNLLINGCTGIAVGMMTNIPPHNIREVCDGIIAYIKNPNISIEELMNFIKGPDFPTGGVIVGRDGIIEAYRTGKGKIILRGKVDVEED------KIIIREIPYMVNKAKLVEKIADLIKKDKLLA-KTVRDESDREGIRVVIELKED--PYSALKKLYDHTPLKVTFNVVMLALVNNEPKLLNLKELIAHYVNHRREVVRRKAEYELKKAEERNHIVEGLIRAIEKLDEVINLIKQSDSTKNAKEGLMK----------------------------------LLRITEKQAEAILQLRLQMLTRLEYESLMKEFNELKGRIDELKSILADPKRVDEIIVEELREVKRKFGDNRRTEIIDKEI---LKEVVEEFGVAVTL--DGQIKRFEI--------------GKALRSNPKI--LLRAMSNLDILLFSSD-KAYSIHARDIPLDF-----TPLSKFISAEKVET--------GVVAKGDVVILSKDGNIKKVRLEEFANAKRAGIIA------GENIGFARLYEDGDVIIATKNGYIVRFRSSEIPEYGRSAKGVKAITLREGDEIAWMSIGKGD-YVLILTRDGYAKKVPIDEFRLTNRGAMGVRGVRGE------IAVAEIVSEEEYYAYTSEGNAVRINVKRIPKGDRYKKGKKIVD-------------------------------------------------
>UniRef50_Q2SS33(1-774:899) DNA topoisomerase IV, A subunit n=5 Tax=Mollicutes RepID=Q2SS33_MYCCT  E=0 s/c=1.02 id=38% cov=84%
MSDKSE-IILYPLEELLGNRFSRYAKYIIQERALPDVRDGLKPVQRRILYAMNQLNLTFDKPYKKSARVVGEVIGKYHPHGDSSIYDAMVRMSQWWKVNIPLVDMQGNNGSIDGDSAAAMRYTEARLTKISNLLLEDLEKDTVIFSPNFDDSETEPTVLPSYFPNILVNGATGIAAGYATNMPPHNLSEIIDATIDIIKNPNITIDQILKIVKGPDFPTGAIIQNKQGIREAFLTGKGKVIISSKWHQE------KNNIVIDEIPYEVVKQDLVKKIGDVIDNNPNLGIKEIRDETDRKGLRIVIELNEKANLETVRKFLFKSTWLSVSYNYNNIIIVDKQPKQLGLIDIIKAYISHYKEVFIKRTEFNLNKTNLRLEIVKGLIKALSILDEVIKVIRKSENRIDAINNLV----------------------------------ISFNFTTNQSTAIVDMRLYRLTSTDVNKLLLEKTELIDKIKKYQEILNDNLVLDNEIISRLEEVKKQFGIKRKSQVEDlvEDLDVDQKEVIIEKEINLWISKDGYIKVIDNNILNKNELSSFGK-----KPNDMWISQGVCSNLDHLILISDQANYYSIPLYKISTSKWKEQGVHINSVATTQPNETIINALVIKEFiNSTQHLLLVTKNGLIKRTQISDLEtKIFNKSFKIMKISDDDSLVYADLISSkTSYCCIVTKNGYAVRYNIEDIPIQSTISKGVKAANLK-DDQIISALSLQTNKDIIIFTNKNNYKKIDQNLIPIYIRPKKGIRILVEKKKN-----------------------------------------------------------------------------------------------
>UniRef50_Q2S2H4(5-757:777) Type II DNA topoisomerase, A subunit n=2 Tax=Rhodothermaceae RepID=Q2S2H4_SALRD  E=0 s/c=1.05 id=38% cov=82%
----------IPLHETARERYLNYALSVITSRALPDIRDGLKPVQRRILFAMFDsLNLYPSKRHRKSATVVGETMGKYHPHGDKAIYDAMVRMAQSFSLRAPLVDGHGNFGSLDGDSAAAMRYTEAKLQPLAMEMLEGLRDETVDYRDNFDGSLEEPVVLPARVPNLLVNGASGIAVGMATNIPPHNLGEVVDAALHMIEEPEVDTSTLVRdHIQGPDFPTGGRILNTqDELAEIYETGSGTIEMRGAYRT-----KGKTRAIIESVPYGVDKSKIVEEIADHIAEENVPQLSNVRDEST-DDVRIVLELKRGSDTEAAMAYLFKHTKLQKRFHVNLTCLVPtestdvKAPKQVDLRTILRYFLDFRLDVVTRRLQNELAELEARIHILEGFETIFDALDEAIEIIRASKNKADAAQRLMHR----------------------------------FQLDEEQTDAILETQLYKLSQMEIEAIRDELGEKRARAEGIRRLLDDEDARWGIVKDELQDIRDEYTDERRSTLVGPGADMEYteEDYIVDEDVHVIVTRDGWVKRQGTYS---------DLDAIRTRDGDEVGWALAGSTRATVGFFTNYGTCYTTRITEIP--STTGYGDPVQKLFSFDDGEHVVGVVSFDDralpdpvpaepseqgelfdpddpdAPDQPYVVAISKGGQATRFTLDGYLEPSiSTGRKYMRLEDGDEVARVHLARGDENICLASHDGRALVFPVHQVSVYKGPAKGVRAIRLEDNDRVLDFALSTRARDGLTVeTNNGREEIVRTTKFDATNRGAKGTLVIK----------------------------------------------------------------------------------------------------
>UniRef50_Q98QI8(10-744:939) TOPOISOMERASE IV SUBUNIT A n=1 Tax=Mycoplasma pulmonis RepID=Q98QI8_MYCPU  E=0 s/c=1.07 id=33% cov=83%
-EQINEKLISQSLDQIMSDRFGRYSKYIIQQRALPDARDGLKPVQRRILYSMMDLKLWNDKPFKKSARIVGDVIGKYHPHGDSSIYEAMVRMAQDWKMNIPLIQMHGNIGSIDDDPAAAMRYTESRLAEISNLMLEGIEKNVVSFAPNFDDSEKEPTVLPALIPNLLLNGARGIAAGFATEMPPHNLGEILDAAIAKIRISSLKVEDLIKYIKGPDFPTGGVIHGLSGIVQAFKEGRGRISLTCKY--EHINLPDKNEILITQIPYGSVKSKIVRDIDEIIVNQKIDGIKEVLDQSDRDGISIAIKLEKKANHESIMKYLFSKTELQVFYNYNNIAIKNGSPTLLNLNELLDIYIEHLKTINVKILEFDLNKARLRLEVVEGFLRVAQITDQIIATIRASNDGK---------------------------------KGVIEDLIRIFAFSQRQATAIAELRLYRLSQTDFYLYQNEKEELIKQINDFEKILNSDNELKTYLVNILKKIKKTYPTPRKTQIIDEELKrnYDIEELVVDEKCYVSLSQDGYLKRVSSKTFKTNDFASFG-----LKENDNLSFLSKATTKDKLLIFSDHGNYAIIPIYKIEEQKSKSFGVHINDFVYFNSYEKIIYVLVVNEFSQDYYISLVTQKGLGKRVSLNKFLITRQSKISnAITLKDDDRLVDVRVSKGKQNIILFTNFNNVVKFSEDALPVISTKGQGNKMIQLSEGEKVSAMSITKTTDNLILITNKNNLIKVPTSHFKFTPRAAKG---------------------------------------------------------------------------------------------------------
>UniRef50_Q7V9E4(3-818:829) DNA gyrase/topoisomerase IV, subunit A n=17 Tax=cellular organisms RepID=Q7V9E4_PROMM  E=0 s/c=0.96 id=38% cov=87%
-----ERLQPIALHQEMQRSYLEYAMSVIVGRALPDARDGLKPVQRRILFAMHELGLTPDRPYRKCARVVGDVLGKYHPHGDQAVYDALVRLVQNFSSRFPVLDGHGNFGSVDDDPPAAMRYTETRLASIAhMALLDEIGEETVDFTANFDGSQQEPSVLPAQLPFLLLNGCSGIAVGMATSIPPHNLGEVVDGLIALIRKPDLSDDKLLGLIPGPDFPTGGEILLGTGIHETYLKGRGSIPMRGVAHVEEiqpgKGRHRRSAVVVTELPYQLSKAGWIEKLADLVNNGKIGGIADIRDESDREGMRIVVELRRDANPENVLGDLHRRTSLQSNFGAILLALVNGQPQQLSLRKLLQTFLEYRELTVIRRTNHALEKTKARLEVVEGLITALNALQAVIAMIQEAADAAAARARLMVQ----------------------------------LDLNEKQADAVLAMPLRRLTSLEQSSLRQEAKELQEKQEQLQFLLENRESMLEVLIQELRQLKKRFNNPRRTRLVEGGDDLVAEraanqrpnAEVQRQQALSALPSDGRILIQQDSQVKVMSPQILGRlhlnEACKLSDGPSPARLIlPIEPAPRLLAVTNNGRVALVR-WEFAGQQPGSLERFLPGGL---EKETLINIFPLP-VDQNLSLGLLSSDGRFKRLPIEEVMELSGRAATIVKLKDGVILKSAFICKANDDVILASNIGRVIRINVnnDSMPLMGKLAQGPMTMRLLPEEMVVGAvsCPPNCESTVLLATRLGKFAKILVSSIRICQRGDLGEIglTIKDSSRDqDRVVDI--CNGNRLVGLVSSQGRHGRIEA------------------------------------------------------------------
>UniRef50_B5ZBW2(1-772:855) DNA topoisomerase IV, A subunit family protein n=22 Tax=Ureaplasma RepID=B5ZBW2_UREU1  E=0 s/c=0.97 id=34% cov=83%
MSVNQQKIINTPLDNIVGESYAKYAKYIIQDRALPDIRDGLKPVQRRILYAMSELGIFHDKPYKKSARTVGEVIGKYHPHGDSSIYEAMVRMSQDWKNNLCLLDIHGNKGSIDGDNAAAMRYTETRLSKIASVMLTNLKKDVVKFSPNFDDSEKEPSILPSLFPNLLINGATGIASGYATSIPPHNPNEVFDALIYRIDHPDCSIEKLIKICPAPDFPTGGEIHDLNGCANAHKTGEGKFVIRASIEFKT-SEAKINQIIINSIPYETNKALIIKEIEDIIYNKEVAGLIEVRDESDAKGVSIIIDTKKDVNLENVKNYLYKKTSLEISYNTKFIAIVHRTPTLVSLSTYLDAQINHSLDVINKVDLYDLNKVLLRIEIVEGLIKCVDLIDEIIKIIRASDSRQDAKNALIQ----------------------------------TFAFTNNQAEAIIMMRLHNLTRTDIFDLRNEWESLQQQAKILKERIKSLQVRKNYLKQKMIEFKKEFGYQRKTKLFDEfiKAEVNEDQMIEKQSLNLVISRDGYIKIVSKKSFESSKYDELG-----LKTNDLLFYHNVINSHDRILIITSKAKLINLIAHKISCMRWKDVGEHLNNYAKFDANEKVVAVYVCNEQfkVDEHQLVLGSKLNLIKRIELNELDlNKNSKQISIMKLNENDGLISANLIKKDHNqfVVAISKLGLVLMFLVHEINCLNRLAKGIKIMKLKPNDEISSILIVPNNGYsIQLFLDQGN-KCFSISELKLSKRA------------------------------------------------------------------------------------------------------------
>UniRef50_Q4A6Z3(4-748:860) Topoisomerase IV subunit A n=1 Tax=Mycoplasma synoviae 53 RepID=Q4A6Z3_MYCS5  E=0 s/c=0.97 id=34% cov=81%
-KEIIEKIITKSVDKIMEERFETYSKYVISNRAIPDVRDGLKPVHRRILYSMYALGLDFDKKFKKSARIVGDVIGKYHPHGDTSVYNAMINLAQWWKMNIPLLSMHGNIGSIDDDKQAAMRYTEVKLAKIANYIIGDIKKKTVKFIPNFDDSETEPIVLPSMFPNLLVNGSRGIAIGMATEMPPHNLGEIIDACVYKIKHPKASYSELSNFVLGPDFPTGGVIKGTKGIAEALENGRnekNKIKLFCKYEIYTKGKN--KFIEITEIPYGVVKVKLVYEIDLIIQNKLIDGIIEIKDRSDRDGINILITLDINSNEESILNYLFSKTQMQITYSYNNIVIDNNSPTLMNLENLISSYIAHIKNVKTLSLNYDLNKAKVRLEIINGFIKVSEITSQVIELIRKTQGSK---------------------------------MGVVNNLIQVFNFTKLQAESIAELRLYKLSQTDKEIYLKEKVEVKETINIIENLLNNEKEFNNFLINEIKAIKKEFSVPRKTQIEEKDFEVSYNklDLVKEEIINVSISKNGFIKRFSDKVLENNE-----WKNYALKEKDNLVFFSKVNTVNFLLCFTNLGNYVIVAIYQIQEVKWKDLGNNINLFAsDIRPDEEIVSVIEVSDFEENLSVMLGTKQGYFKRVMLKDFLVSRfTKKYTAMPLNEDDYLIKAKLTNLDSYLVAITENSIISKFSESEIMFYSTKARGSKAIYFSVGDKLSNFTIASYGDEIFAFS-------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q4A8X9(1-722:846) Topoisomerase IV subunit A n=3 Tax=Mycoplasma hyopneumoniae RepID=Q4A8X9_MYCH7  E=0 s/c=0.98 id=31% cov=81%
MNKSLDSVINSRLEKILAEKFIRYSKYVIQQRAIPDVRDGLKPVQRRILYSMWQLGLKNSKNYKKSARVVGDVIGKYHPHGDFSIYDALVRLAQEWKMNSPLVEMHGNKGSIDDDPPAAMRYTEVRLAEISEHLLELISKNVVSFCPNFDDSEKEPTILPAIFPNLLINGAIGIASGFATEIPPHNLGEVIDATILMIKNPGITIEEISTIILGPDFPTGGIVYGKSGIFDAFKTGKGKIKISSDYKI--FEKNGQNVIEITSIPFGISKSSLIEEIDDIRFDAKIYGIKNVIDQSDQNGVSILIELEQDGNPDLIINYLLQKTHLQIHYSYNSVAICDNSPKLLSIKEMIFYYLEHLRKIKLAEFNFELYKNKKRLEIITGFLKVADITDEVIKVIRASDNSK---------------------------------VGVVSDLIKFFNFSQTQAEAIASMRLYRLSKIEQQIYLEESKNLEKNIARFKKLIENKDEFDKNLINMLTDFKKHHGKPRKTkiIDSDIKIKINKDELVKDEFFYFWITKSGLYKKLDIK-----NSLPDEIEKTQLPNGDFFIFQGIINQKQKAVFLTNKGEIAILAVHQIPELNLKNSPNNLKITLGIPNNQQILSVFFADSFESSQFLIFISKFSFAKRMNLDQLMKIKQKKLQNIfRFKEGDELISVFLEEKLKNIVLITTQNRALKMSISEIPIYTRNSTGIKIFRHRKNEFISASQTIESSESLAVI--------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q21V46(24-780:796) DNA topoisomerase IV subunit A n=83 Tax=Bacteria RepID=Q21V46_RHOFD   E=0 s/c=0.92 id=39% cov=78%
----------LNLATYAQRAYLEYALSVVKGRALPDVCDGQKPVQRRILYSMSRMGLGFGGPngntgakPVKSARIVGDVLGRFHPHGDSSVYDAAVRMAQDFSQRYPLIDGHGNFGSRDGDGAAAMRYTEARLAKITGLLLDEIDEGTVDFMPNYDGSTQEPSQLPARLPFNLLNGASGIAVGLATEIPSHNLREVADACIALIKSPQLSESDLFALIPGPDYPGGGQIISSaEDIAEAYRSGRGSLKCRARWKIE-DLARGQWRLVLTELPPGVSTQRVLEEIEELSNPKVKAGkkalsleqnqlkatllsvLDGVRDESSKDaAVRLVCEPKTSRISQQeLITTLLAHTSLETSSPINLTMIgLDGRPTQKSLRQMLTEWIAFRQKTIERRSQHRLGKVLDRIHILEGRALVLLNIDEVIAIIRQADEPKAA---LIAR----------------------------------FHLSDRQAEDILEIRLRQLARLEAIKIEQELAGLRGEQQKLEEILGSPSALRRLMIKEIEADAKTFADPRRTLIQAEKKAV-LEVKVVDEPVTVVVSQKGWVRAQKGWASERAANGVL-PAEYSFKAGDALYDTFECRTVDTLLAFGSNGRVYSVAVALLPGA--RGDGQPMTSLLELEAGTQLLYYFAGP---APATLLLSSSGGYGFLASVENMTSRLKAGKAFVTCNAGEILCrpspvaggsGATPWPAATHVACASAGGRILTFEISQLKTMATGGRGLMLIDLEDKDRLAGA--------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A6TSS8(1-803:930) DNA topoisomerase (ATP-hydrolyzing) n=7 Tax=Clostridiaceae RepID=A6TSS8_ALKMQ  E=1e-177 s/c=0.78 id=30% cov=86%
MDKSINEIEVQEIEDTLESNYMPYAMSVIVSRALPEI-DGFKPSHRKLLYTMSQMGLLTKGR-SKSANIVGTTM-KLNPHGDQAIYETMVKMTRGHQgLLHAYVDSKGNFGkvySRDMREASA-RYTEAKLEKFTQEIFSNIDKNVVDFVDNYDSTTKEPTLLPTTFPNILVKYNKGIAVGMAEHIPSFNLKEVCEATIAYLKDKEI---DLLEYLKAPDFSTGGeLIFNEVTMKQVYHTGRGTFKVRGKYRYV----KADNAIEIYEIPYTTSIEAIIESIIELVKKGKIKEITDIRDETDKNGLKITIDLKRGVNPDDLMVKFFKWTKLEDSFGCNFNILINGHPKVMGVKEILDHWIAFRLSCLKRQVQFEIDKLEEKLNLLKGLEKIQLNIHEVVDVIQNTKKDKDVIANLMEQ----------------------------------FDLNLAQAEYIAEIKLRSLNQELILKKIKEISAIEKELKRLGMVLARESKQNEIIVNDLKRISEAYGIPRKTDIinENEVEVLSEEILIENYNMKLFLTNEGYIKKISLASLRSSGDH-------KLKDNDYIVQEIDGTNRGEVLLFSNKETVYKIKAYELEDSKASNLGQYLNNVLGLSSDEIILHIVCTEDYQG--HMLFFFENGKGAKIPITSYETKTNRKQLANAYSGDSPLVYISSIEEDLEMMATSNLNKTLIFNTEEMSPInSRNSKGVqvfkckKGISLKKikpmdevsPDEMLNQKVLDENPRVkFFLTKGGYIKKIPLTTLVEDEE--------QRLKKDDYIIQEVEGAEEGELLLFSNKQILYKTKAREL---------------------------------------------------------------
>UniRef50_C0QRN3(534-1216:1217) DNA gyrase subunit A n=9 Tax=cellular organisms RepID=C0QRN3_PERMH   E=1e-172 s/c=0.89 id=35% cov=75%
--------------------------------------------------------------------------------------------------------------------------TEARLTKLAMEMLADIDKNTVDMKENFDASLMEPEVLPAKFPNLICNGASGIAVGLSTNIPPHNFSEVAEALKYLAEFPNATVEELCQFIKGPDFPTGGIlITPFEEIVKIYTDGRGSVTVKGKARIER-LPGNRHRIIIYEIPYQVNKVELIKRIAELVRKGQEKGISDLRDESDRDGIRIVVELKREADPEKVLKKLYRRTQLQKSIPINLTVLVGKQPKTVDLKGLLQEFIKHRVDVITRRTLFDLEKAENRLHIVEGLLKALENADRVIDIVRSSKDVSSARSQLVEE----------------------------------FELSDTQAQAILDMRLSRFTALEGDKLYQEADDLRLKIEEYQRILSSEEEKIRVFIEEIDELLEKFGDERKTVIVEEKEA----GLTFEEHYILAVLSSGRIlnRRIDDDADKKDIFQKVmNEVVSSVKPGEKLISVQEVESSIPIAFITDKGKAYWSLVADLPKGEGR---------INIDEGEIVGTAF--KGEGEEDRLFILTKNGIIKRMSYEDIFYKSQNHSI-IPLAEDDCVVTAFADDHPSLIGVYTRKGDLLLFERNQVRVTGDKAKGVEAIDLDEGDTVAGGFLINSEDLIMTVTKNGYTKLVRKEEFftkegKVKKRAQKGLMAVKLG-KDDFLSVAVPVELDETVYFSTEKGRVLKLIVDQkrIPVAKRTAMGDPVLKI-EGDYVV-----------------------------------------
>UniRef50_Q4N468(97-979:1014) DNA gyrase subunit A, putative n=2 Tax=Theileria RepID=Q4N468_THEPA   E=1e-149 s/c=0.60 id=30% cov=83%
------------LNDYMCSSFLKYALSIILGRALPDSRDGLKVVHRRIIWAMHMLKLDPNGQYRKCAKVVGDVLGNYHPHSDKSVYDALCRLSQDFIMKVPLIDGHGNFGS-NNDPPAAMRYTECRLTNFSKMiMLNDINFNTIDYIPNFDNTNIEPMVLPCRLPNILINGSSGIAVGLATNIPPHNPTEVINATIQFIKShlntttettaetrsdttvdglKDDKNVEIVNEVMGPDFPTGGVIRtTREAMRKIYESGKGTVLIQSKFVFEEKfrdvinvynnfkdikfKHNSRISIVINQIPYNTRINDIIENINRNIKNNNIIGVNDVKDESDRNGTRIVVELKRNISSvieiQEIMAKLQRLT--EYNYKCNFITLDQDKPIRFNLYTILKIWLDFRLKVLKRKYKHLLLKLKKNLDIINAYIIIYLNINTIIN------------------------------------SFQNHQKGVYKVLKEEFKLNDDQMKSVMRLTLRQLNQLNIDNLKEKSGEYTKQIEFYENVLNNDTNLYNEIISDLTELKDHFKNiKRNTLIIYTDEGSNFEttvegvegpegtsedkvdpSVVESDDNIIIYNSLGRISKIKLDQKfyksnknksirisnpihshsttpdtsiesstpdsNKNNRAKKGETKIDEAAALEVGYCSNNNSNKIIIILKN-GRIMHVNSSKLKLCK---KGYDMFKYLGIKNDEMIEYITSIGKHLGDI-IMVGYGNGIMTICNTNRLNLKLSKTKLNLKLNLKNKEIKFFFNYNLNHIsqnpflFICTKRGYCIKISLRSIMEKFDKKKNVKLIRLHKGDEVVSSCLANDQQHILILTSKgkhqrhnlyvGKYKLININDIKLQKIKGKGYNILRNSQK------------------------------------------------------------------------------------------------
>UniRef50_B4D1N9(68-701:745) DNA topoisomerase (ATP-hydrolyzing) n=1 Tax=Chthoniobacter flavus Ellin428 RepID=B4D1N9_9BACT  E=1e-116 s/c=0.66 id=26% cov=69%
--------------------FLEYASYVILDRAVPHIDDGLKPVQRRVLHTLWDMD---DGRFHKVANVVGATM-KLHPHGDASIEAALVAIGQ----RGWLIEPQGNYGnTLTGDAAAAARYIEARLTPFARDVL--FNPKTTVWQQSYDGRTKEPVTLPAKFPIVLLEGAEGIAVGLSTKILPHNFNDLCRAAINHLQGKTFRIL--------PDFPTGGT-----GDFTDYNDGErgGKVKVRARIE-----EHSKSVLCITELPYGVTTESLIESILAANAKGKIK-IKHVDDNTASK-VEILVHLPPGSQPDKVVQQLYVFTSCQVQLNPAACVIVrdpetgEDRPQFMGVRDILKASVDATKELLKQELEIKLGELEQQWHW-------------------DSLERIFIEERIYRRIEKSQTWESVLEEIRTGLKPFIGNLRREVTEEDIVRLTE--------IRIKRISAYNRFQADEALKKIEEAIKETKHHLKN---LVAYAVDWFERLQEKYGKgvKRRTT-YDEIAQIDASA-------VVSANQRLYVNRED------------GFIGLNWRQHEFVT---ECSILDSVLTIMRDGSLKVTKVAD-----------------KVFMGRKIIHIGLWPKDGDMNFYTMVYQDGETGKAFAKKFQigGLSRDKLYSLVKSEDSKIIFLHISPSEQAMpktLHVSVDGRSgarvreLDFDLTALPVSTRTSKG-----------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q02880(718-1202:1626) DNA topoisomerase 2-beta n=175 Tax=Eukaryota RepID=TOP2B_HUMAN   E=1e-106 s/c=0.80 id=24% cov=49%
-------------------------------RSIPSLVDGFKPGQRKVLFTCFKRN---DKREVKVAQLAGSVaeMSAYH-HGEQALMMTIVNLAQNFvgSNNINLLQPIGQFGTRlhGGKDAASPRYIFTMLSTLARLLFPAVDDNLLKFLYD-DNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRMLDGLD----------PHPMLPN-------------YKNFKGTIQELGQNQYAVSGEIfvvDRNTVEITELPVRTWTQVYKEQVLEPMlngTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMgclKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARfILEKIQGKITI--ENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEDETQNQHDDSSSDSGTPSGPDFNYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C3X0L8(1-379:379) DNA gyrase subunit A (Fragment) n=1 Tax=Fusobacterium sp. 7_1 RepID=C3X0L8_9FUSO  E=1e-101 s/c=0.98 id=39% cov=43%
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EKIDTEFKEIEALIKELREVLEDNNKIYDIMKKELLELKEKYADKRRTKIEEERMEILPEDLIKDEEIIITYTNKGYVKRIEASKYKAQRRGGKGVSALNTIEDDYAEKITSASTLDTIMVFTDRGKVYNIRAYEIPDLSRQSRGRLLSNIINLSEGEKVRDTIVIKEFLPEKEVVFITKNGLIKKTSLGEFKNINNSGLIAIKTKEDDDIIFVGLIEDvnKEEILIATHDGYCTRFLTDTIRATGRSTQGVKAITLRKGDMVVSaMLIKNPETDILTITENGYGKRTSLDEYPQYNRGGKGVINLKVNEKNGKVVSVLEVSEDEELMCITSNGIVIRTSINEISRIGRATQGVRIMKVADDEKVAAITKIKKEEDLEN----------------------------
>UniRef50_P41001(712-1198:1398) DNA topoisomerase 2 n=10 Tax=Eukaryota RepID=TOP2_PLAFK   E=1e-101 s/c=0.76 id=22% cov=50%
-----------------------------TERSIPNIMDGWKPGQRKVLYGCFKRNLRNEC---KVAQLVGYIAehSAYHHHGESSLQQTIINMAQTFvgSNNINFLEPCGQFGSRkeGGKDASAARYIFTKLASSTRSIFNEYDDPILKYL-NEEGQKIEPQYYIPVIPTILVNGCEGIGTGYSSFIPNYNYKDIIDNIKRYINK-----EPLIPMVP------------------WYKDFKGRIESNGKTGYETIGiinKIDNDTLEITELPIKKWTQDYKEFLEELLTDEKHQLILDYIDNSSHEDICFTIKMDPAKLQKAEEEGLEKVFKLKSTLTTTNMTLFDpnlKLQRYSTELDILKEFCYQRLKAYENRKSYLISKLEKEKRIISNKTKFILAIVNNELIVNKKKKKVLVEELYRKGYDPYKDINKIKKEEIFEQELLDAADNPEDNEEIIAGITVKDYDYLLSMPIFSLTLEKVEDLLTQLKEKERELEILRNI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q4RIW2(828-1334:1568) DNA topoisomerase 2 (Fragment) n=1 Tax=Tetraodon nigroviridis RepID=Q4RIW2_TETNG  E=1e-100 s/c=0.73 id=26% cov=51%
-------------------------------RSIPSLVDGLKPGQRKVLFTCLKRN---DKREVKVAQLAGSVaeMSAYH-HGEQALMMTIVNLAQNFvgSNNLNILQPLGQFGTRinGGKDAASPRYIFTMLSPLAKLLFPAVDSNLLKFL--YDDNQKvEPEWYIPIIPMVLVNGAEGIGTGWACKIPNYDVREIVNNINRML-----SRQEPLQMLP--------SYKGFKGV--IHELGQNQYLVSGEVSV-----IDKNTVEITELPVRTWTQAYKESVLEPMlqgSDKTPALISDYKEYHTDTTVKFLVRMSEEKLAQAEAAGLHKVFKLQSSLTCNsMVTACFHRPehvlfdhmgclkRYESVQDILKEFFELRLHYYKLRRDWLVGSLGAEAAKLSNQARfVLEKIEGKISI--ENKSKRELIRMLVQKGFESDPVAAWTRAQEKElrrfqskreprQAQEEDEGNDSDSSLDSGSSSGPNFNYILNMPLWCLTKEKVEELLKQRDLKRGELNELQR--KSPEDLWKedlaVFVEELEKL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D1ZCL6(790-1268:1915) DNA topoisomerase 2 n=6 Tax=Sordariomyceta RepID=D1ZCL6_SORMA   E=1e-99 s/c=0.77 id=22% cov=50%
-------------------------------RSIPSMVDGLKPGQRKVLFGCFKQNLIHDQ---KVVELAGYVSkeAAYH-HGEQSLQQTIVGLAQNFvgSNNINCLEPSGNFGSRlsGGSDAASARYIHTRLSPLARKIFHPLDEPNLEFQFD-DGKLIEPKVYAPILPMVLVNGADGIGTGWSTSIPNYHPLDIVENLKRRMGRDSSGDGEEKPFEPmTPWF------RGWKGTPE--PDGPNKFKFNGIVEVNPQ---NPNEVDVTELPIRMWTDDFKSKLEEIIRGDKGPsWIKDYKEYNDHQTVHFIIALEEKQMSSALRDGLIEKFKLTKTVATTNLVAFDTRGKIYkyeNPQEIMEEYYHYRLNLYGERKKHWLKVYHADYRKLQNQYRFISEIienKLIVAKKKKSVLVQELRERKYEAFPPKSDGRNVKSPDEELGAAENEDEEDAVGGARDY-------DYLLSMPIWSLTFERLDKLKQQIAAKKAEYDELDAL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q9Y8G8(714-1195:1587) DNA topoisomerase 2 n=79 Tax=cellular organisms RepID=TOP2_PENCH   E=3e-96 s/c=0.74 id=25% cov=37%
-------------------------------RSIPSVVDGLKPGQRKVLYTCFRRNLKKD---MKVVELAGHVSGttAY-QHGEGSLQQTIVGLAQTFvgSNNVNCLEPSGNFGSRlqGGADCASARYIYTRLWPFARRVFHNHDDPLLTYNED-DGAKIEQEVYVPVVPMILINGADGIGTGWSSSTPNYNPEDIVENLKRMMDGEPLKPMQ-------PWF------RGFTG--EVTAVGQDRFKFSG-----IIKETGDKEVEITELPIRTWTQDFKDKLEDIIKAEKTPSfIKDYKDYNTHTKVHFVIQMDEKHMKTAIAEGLEEKFKLSKTMtTTNLVAFDPERItKYASVEDIMKEFYAVRLKYYERRKQYQLSEMQKEL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C3GSY0(46-683:745) DNA gyrase subunit A n=3 Tax=Bacillus thuringiensis RepID=C3GSY0_BACTU  E=9e-96 s/c=0.55 id=30% cov=60%
------------------RGYIDYAREVLTNRALEDIRDGLKPVQRYALYWMFKEK---AKDMIKSEQVGAGVL-KYHPHNADSAYESLTKMVESNGTFYvPLLIGKGELGKKfSNGSPAASRYTSVKFHENAKEMFTAMD--GIDMVWNFDDTERVPEVLPASVPYILMKYADGIAVGFSTKSPSFLPQDVTNLVREYIRDGKCST------MIVPDFSTGGFIsYTEKELEKLMKTGKGSFMTRGKVFI------DGKNIVVTEVPQGVT----VEKIMKEIEKAEIQGITpnGYSDLTGKDGCYFEITCRAKNRVQEVLMELYTKTSLQKKFNSNLLAVESKKLVITGVWGIIDRWVKWRRKVLTRQTRLDLAKLVESAKYTKGFIDLLAIEgarDEIVELTTKKSD-NDAIKRIQEYIQCERDV----------------------------------AEWIIKRRLNQFRNDN--KYINQYANYQIEIAKLEKYLEN---IDTLILEDMDRfdllVSKKH--ERRTEITNKVYEVET---VKEDEIEIPVSECYYqIKDGFLRKLHVKPTSGEGI-------------IFEGYTNSTIIALSSEGEIFRIYGNDINYLTGNDIGTYI----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D2UZM0(693-1170:1457) DNA topoisomerase II n=1 Tax=Naegleria gruberi RepID=D2UZM0_NAEGR   E=3e-92 s/c=0.72 id=24% cov=48%
-------------------------------RSIPSIVDGLKPGQRKILFSCFKRNL---KKEIKVAQLAGYVSeqSAYH-HGEDSLNGTVVNMAQNFvgSNNINLLYPGGMFGTRlqGGKDSASPRYIFTKLSEITRYIFPKADDPVLEYLDD-DGQSIEPRFYVPILPMVLVNGSEGIGTAWSTNIETYNPVDIVEGLKALIKGEEA--KEFHPWYKGFD----GIIERLAPTK--WQT-KGVIE-----------KIDDNTLDISELPIRIWTESFKERLEKMMEAQQVD---DFRENHTDVTVSFTVKMTDKQMKDAEDAGLYDYFKLFKKFSTSNMVLFseeGGIKEYETVLDILKEFYPIRLKFYGKRKEYMLEKMKKELEILSNKVRFImEVINETIQVKkrKKADLLKELKTKKYSSFPKEKKIAAAGDIQNEEEEEEEDEEKDVADLTDGY-------NYLLSMPLWSLTVEKVKKLEKEKEEKVKEVEQLE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A0C0L0(652-1160:1274) DNA topoisomerase 2 n=3 Tax=Paramecium tetraurelia RepID=A0C0L0_PARTE   E=6e-88 s/c=0.64 id=24% cov=48%
-------------------------------RSIPSLMDGLKPGQRKVLFACFKRNL---KQEIKVVQLGGYIAehSAYH-HGDLSLVSTIIGMAQNFvgSNNINLLLPKGQFGSraMGGKDHASARYISTALNKITRYIFPEQDDHLLKYQED-DGQMVEPEYYVPIIPMSLVNGAEGIGTGWSTSIQNYNPIELVNQIKNRLDGQPFQ-------------PMTPFYRNFDGIIENLPNGNGIIK------GIIDCNEATDIITIRELPIKKWTRNYKEWLDkEMAEEG--SQIVDLREYHTKYKIHFEIQMVDGFVSD--LKNPLEYFKLSTPASCSNMVLFDSNNKIKKyecVSDIMEEFYQVRLQFYHKRKEYLVSKLDREVQLLDNKLKFIkmviseeiqirnvKKIDLVKQLDKngftrfsqliqvKSTKVKAFGDSQKQKKNVDDDESEDEQVSEDEDKQQKKQIQKKLQSTPSIDISE--FNYLLSMPLFSLTYEKVEKLQEELNQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q27537(313-772:842) Chromosome instability 4 n=3 Tax=Chromadorea RepID=Q27537_CAEEL   E=5e-87 s/c=0.71 id=24% cov=48%
--------------------------------------DGLKPGQRKVLFACFK---RANKREVKVAQLAGAVaeISAYH-HGEQSLMGTIVNLAQDYvgSHNINLLLPIGQFGTRlqGGKDSASARSIFAQLSQVTRTLFPAHDDNVLRFLYE-ENQRIEPEWYCPIIPMVLVNGAQGTGTGWSTNIPNYNPRELVKNIKRLIAGEP-----------------------QKALAPWYKNFRGKIIqidpSRFACYGEVSV-LDDNTIEITELPIKQWTQDYKEKVLEGLmesSDKKSPVIVDYKEYHTDTTVKFVVKLSPGKLRELERGQdLHQVFKLQAVINTTCMVLFDaaGWLRTYTSPEAItQEFYDSRQEKYVQRKEYLLGVLQaqsKRLTNQARFILATINnkivlenkkktaiVDVLIKMKFDADPVKKWKEDQKLKELRESGEIELDEDDLAAVAVEEGEDISSAAKAVETKLSD--YDYLVGLALIKLSEEEKNKLIKESEEKMAEVRVLEK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q5KSK9(750-1250:1572) DNA topoisomerase 2 n=5 Tax=Basidiomycota RepID=Q5KSK9_COPCI   E=3e-83 s/c=0.62 id=21% cov=51%
------RLEEIPYSEFINKELILFSMADNV-RSIPSIADGLKPGQRKVIWGCFKRKL---KKEIKVAQLVGYISehAAYH-HGEASLAATIINLAQDYvgSNNLALLSPNGQYGTreIGGKDHAAPRYIFTNAKSITRAIYHPFDDPLLNYLKD-DDVPIEPEWYMPTVPMVLINGAEGIGTGWSTNIPPYNPVDIVANLRRMMKEEE----------PEPMTP---WWRGFKG--EVRPTGKGKYDVVGVA-----TKINDTTVEISELPIHKWTRTFKDELEAMITGekkdkdkdkdkdedgkkdvvKNAGMVKDFKEHHDNLNVLFEVTMNPKDLEKAEEKGLVEFFGLTTKVSTTNMILFDfegKIKKYETPEEILKDFYPMRLAYYQKRKDYqalELSTAYDKLNNQIRFIEMIIKKELVVSNRKKADIVAELRKLNFRPFPKVAKTKTAKPDEEEEESEDEEEESGSEAVTD--------FDYLLGMAIYSLTRERIEKLKQQAHEKEQE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B8C981(700-1160:1179) DNA topoisomerase 2 (Fragment) n=1 Tax=Thalassiosira pseudonana RepID=B8C981_THAPS  E=2e-82 s/c=0.67 id=23% cov=49%
-------------------------------RSLPNVVDGLKPSQRKVLYACFKRNL---KDEIKVAQLAGYCAEhtAYH-HGEASLHSTIIGMAQDFcgSNNINLLTPSGQFGTrlMGGNDAASPRYIFTHLSPLSRLLFPVDDDMLLNYKEE-DGQMIEPEYFCPIIPLLLVNGCQGIGTGWSTFIPQHNPLDVLNYIRAKLD--ETKKPAIRPWVKG---FEGGITVDSK---------------RGDYVTEGIITPQKNsSVVISELPVGVWTNDYKATLVAML---KKAEIKSFSQNHTTTTVSFNVKVNAAKLNRLLKGDMLKTFKLRKALSTrNMHAFttDMKIARYNSPEEIADAFFPVRLDLYADRKSVLESNMEYSASLMRNKARFIEAVSaNKIDLLHGRKSKEATTALLEEMEFSKQSELDAIKSNNNIAQRRESsnvVMDEFMSDEESAKGAAKEYDYLLNLPLSSLTLEKIDALNDDAAKTDTKLEQIK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_P34534(582-1054:1054) Putative DNA topoisomerase 2, mitochondrial n=5 Tax=Caenorhabditis RepID=TOP2M_CAEEL  E=3e-80 s/c=0.64 id=24% cov=49%
-------------------------------RSIPSLIDGLKPSQRKILWTL--LNNMDESTEIKVSQLAGAVAHRqsYH-HGEESLVRTIIRMGQTFcgSSNLPLLQPIGQFGTRheGGNDAASARYIFTALAPTTRLLFPQADDDLLQ-KNVEEGMVVEPTWLCPIVPLILINGTEGIGTGWSTKIANRNPIDIIDMIRRKID----------------------SISTEYEIPPFYEEFRGKLEVvtptkfisSGKIQLIRPERKNASTfsIEIVELPIGIWTSKYKEKLSKIVETLPVLEFSERHTEK-RVHFRITLDRKKSSRFLQKSNsDLLNYFKLRTSLTENRVLFDrNGELKEFgNISEIAAEFFEVRRDLYEKRLKIQKEECEAKLIYVENQLNFIEMVtNGTIEI--RSMGRNQLEEKLQEMGFRVDPMATIAKNSKKAN-----------------------YGYLLEMPVSRLTSDEMKRLEERKSRRRTELEAAES--ADWKSVW---RSELDKLAEAVGNNRKS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q04PE8(8-458:462) DNA topoisomerase (ATP-hydrolyzing), subunit A n=6 Tax=Leptospira RepID=Q04PE8_LEPBJ  E=7e-80 s/c=0.67 id=26% cov=50%
-------------EDQVNDDQRKYSRYVCDSRAIPHEIDGLKPVQRRILWAMW--NSDARNRYTKTVKVAGLAMG-YHPHGDKSIQDALSQMAQDFTfaNNIPLVSGEGTFGDVLDPSAiASPRYTEVKLSDFVKDLGFFESLPDIDYVKNYDETEDEPIHFVGKVPIVLLNNIQGIATGFRCFIPGHRLADIVKSQINYLKTKK--PLSLKPWYK--DF---------NGEVKMAETETGNITMSTTFAFKWEG----DILYLTDSPMNWNREKVISLLDDIL-ERKDSWLKEYVDYSSQT-FRIELQYKKGEKPsQKEIMALFNKEDIQTL--AMNVITYDGKLKNFKPEEIIKRFCDFRKTHLIRRFK-RLSGLEE------------EKIERNSELIR-----------FIKEKWNEKVIGIKSKKDFEDKLKASKFKY---------------FEWLSTIPVYRMTIEEVKKCEEAIIEAKTTLARYQGLVKEDKKLTDYMITELNELQNK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_O41065(630-1047:1061) A583L protein n=7 Tax=Chlorovirus RepID=O41065_PBCV1   E=1e-77 s/c=0.70 id=26% cov=44%
-------------------------------RSIPSVVDGFKPSQRKVLYCAFKRNLTSD---VKVAQFSGYVAehSAYH-HGEVSLQGTIVNLAQDYvgSNNINWLLPEGQFGSRlqGGKDHASARYIFTKLNPKTRQVFVDTDDNLLKYLYD-DGDKIEPECYVPIIPSILVNGSSGIGTGSSTNIPSYNPKDIVDNVKRLISGEDLV-----------------------EMKPWYKGFKGKImeTSPGVYVTKGLYMPNGKTIVVSELPVGKWTHDYKEHLDGLLEKKI---ISYFREKHSDTDVLFEIDFVGNPNIDIL--------KLETTIrSTNMHAFDpsGKIKKYDTPLDIIRDWFEVRKDLYVKRKAYLLEDLTHRTNIAQNKHRFITMVnnDEII-----------------------------INKKHESVISAELEKLNFYKVDGKY-------DYLLNMRISSLTLERATELEREAVKLNKELDDL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q57532(12-1245:1273) Mle gyrA intein n=207 Tax=cellular organisms RepID=GYRA_MYCLE   E=1e-73 s/c=0.23 id=29% cov=94%
-----QRVEPVDIQQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMLDSGFRPDRSHAKSARSVAETMGNYHPHGDASIYDTLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYcvsgnslvrllfgksirigdivTGAQFNSdnpidlkvldrhgnpvVADYLFHsgEHQTYTVRTTEGYEitGTSNHPllcLVNVGGIPTLLWKLIGEIRSGdyvVLQRIPPvefgpadwystmeallfgafisggfvfqdHagfnsldrdyftmvvNAYDTVVGGLRCISSRitvsgstllELDVYNLIEFKKTrlsglcgqrsadklvPDWLWHSPSTVKRAFLQALFEGEGfsSILSRNIIEISYSTLSERlaadvqqmllefgvvserychtvneYKVVIanraqvemffTQVGFGVTKqAKLIRDVvsmspcvgmdincvpglatfirkhcdnrwveEDSFNQHNVDCVQHWHHHSaeivghiADPDIRaIVTDLTDGrfyyaRVASVTDTGIQPVFSLHVdtedhSFLTNGFISHNTEARLTPlamemLREIDEETVDFISNydgrvqepmVLPSRFPNLLANGSggiavgmatnipphNLYELADAVFWCLENHDadeetMLVAVMERVKGPDFPTAGLIVGSQGIADAYKTGRGSIRIRGVVEVEEDSRGRTSLVITELPYQVNHdnfitsIAEqVRTGRLAGIsNVEDQGSDRVGVRIVIEI------KRDAVAKVVLNNLykhTQLQTSFGANMLSIVDGVPRTLRLDQMIC---YYVEHQLDVIVRRTTYRLRKANERAHILRGLVKALDAlDEVITLIRASQTVDI---ARVGVVELLDIDDIqaqaildmqlrrlaalerqriiddlakieveiadlgdilakPERRRGIIRNELTEIAEKYGDDRRTRIIAVDGDVNDEDLIAreevvvtITETGYAKRTKTDLYRSQKRggKGVQGAGLKQDDIVRHFFVCSTHDWILFFTTQGRVYRakayelpeasrtargqhvanllafqpeeriaqviqirsyedapylvlatraglvkkskltdfdsnrsggivainlrdndelvgavlcaadgdlllvsangqsirFSATDeaLRPMGRATSGVQGMRFNADDRLLSLNVVREDTYLLVATSGGYAKRTSIEEYPMQGRGGKGVLTVMYDRRRGSLVGAIVVDEDSELYAITSGGGVIRTTARQVRQAGRQTKGVRLMNLGEGDTLLAIARNAEE---------------------------------
>UniRef50_Q9QSK1(683-1121:1132) DNA topoisomerase 2 n=1 Tax=Invertebrate iridescent virus 6 RepID=TOP2_IIV6  E=1e-70 s/c=0.62 id=23% cov=45%
-------------------------------RSLPHLIDGLKESQRKVIFGLKQWN---GKNNIKVAQLGAFVAQKtdY-KHGEQNLFDTIIKMAQTFvgANNIPLLEEDGQFGTRlsGGKDAASPRYIFVNQPPILNKIFRPEDDPILNYTL--DG---EPVFYAPVIPLICINGSVGVGTGFSCNIPMFNPSEIIDGLKQWINMREQGEKYVFKYKP--------WYKGFTGKIE--KNGSGRYISYGTLSNEA-SNNGMYQYTVSELPINMWTDKFKE-MCDQYRESNL--IKTCDNYSEVTTVNFKI----SSEHELTIENL----KLRSYIHTSNMVMFDHEGkihKYETLNGIMQRFCKERIKIYEKRRQYMLQKLNKSLTI------------------------SENKKRFME---------DVMNQKIKILLQEDEVVHQQLLDMNYYKDDEGEFDYLLNMNIGGFRKKNVDKLISKIDDLKKDI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D2TEU4(642-1097:1103) Putative DNA topoisomerase n=2 Tax=dsDNA viruses, no RNA stage RepID=D2TEU4_9VIRU  E=2e-66 s/c=0.56 id=26% cov=44%
-------------------------------RSIPKMLDGQKAGQRKVVfYALNHVG----KNEAKVAQMAGTAAQvtQYH-HGEVSLANTIIGMAATYtgSHNLPLLYPSGQFGSRHAKnSAAAPRYIFTHISSFLPRLIKSEDNDVLTY--NVDENKKvEPTVYIPVIPIVLVNGANGIGTGWKCDVPQYNPLEVIDACKRMANGGELSTSKWVPWY-----------VGYNGKMEETTDGFNSI---GTYEVSGN------TLTVTELPIGRATEDWIESIQSLIPDK----IKNY--EKNLGPDSVTIKLNLTSPIDDPVATLKLSTKLQT----NRMWLYNAKNKIThyaGPTQIIQEH------------------ARERLKLYEASR---------ISQIEKASHKMDLLNNKIRYIMEFIEGKIKIGKMSTSSLNEYLAQNGYLRSNNSFRyLTD-------DISTGQLTTDNVDKLRNQIRNITTDIDALRE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C9MZF3(2-195:196) DNA gyrase, A subunit n=1 Tax=Leptotrichia hofstadii F0254 RepID=C9MZF3_9FUSO  E=1e-49 s/c=1.04 id=40% cov=21%
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FDNIKKAGKRAIKLNDDDEVMYIGLTSGtsEDEVFAATRNGIAIRFSEKDVRSMGTGAAGVKGITLRDKDKIVGAAIInsemnNDEMRILTITEEGYGKRTKLSEYRLTSRGGKGIINAKLNDKTGKIVDVKIVTENDEIMLITSEGTLIRTSVNNVSVIGRSASGVRIMKVRNNEKIASVVKITEEPE-------------------------------
>UniRef50_P48372(1-923:923) DNA gyrase subunit A n=78 Tax=Bacteria RepID=GYRA_PSEAE   E=0 s/c=1.16 id=67% cov=100%
MGELAKEILPVNIEDELKQSYLDYAMSVIVGRALPDARDGLKPVHRRVLYAMSELGNDWNKPYKKSARVVGDVIGKYHPHGDTAVYDTIVRMAQPFSLRYMLVDGQGNFGSVDGDNAAAMRYTEVRMAKLAHELLADLEKETVDWVPNYDGTEQIPAVMPTKIPNLLVNGSSGIAVGMATNIPPHNLGEVIDGCLALMDNPDLTVDELMQYIPGPDFPTAGIINGRAGIIEAYRTGRGRIYIRARAVVEEmEKGGGREQIIITELPYQLNKARLIEKIAELVKEKKIEGISELRDESDKDGMRVVIELRRGEVGEVVLNNLYAQTQLQSVFGINVVALVDGQPRTLNLKDMLEVFVRHRREVVTRRTVYELRKARERGHILEGQAVALSNIDPVIELIKSSPTPAEAKERLIATAWESSAVEAMVERAGADACRPEDLDPQYGLRDGKYYLSPEQAQAILELRLHRLTGLEHEKLLSEYQEILNLIGELIRILTNPARLMEVIREELEAVKAEFGDARRTEIVASQVDLTIADLITEEDRVVTISHGGYAKSQPLAAYQAQRRGGKGKSATGMKDEDYIEHLLVANSHATLLLFSSKGKVYWLRTFEIPEASRTARGRPLVNLLPLDEGERITAMLQIDlealqqnggadddldeaegavlegevveaaeveevegetaelvAEPTGAYIFMATAFGTVKKTPLVQFSRPRSSGLIALKLEEGDTLIAAAITDGAKEVMLFSSAGKVIRFAESVVRIMGRNARGVRGMRLGKGQQLISMLIPESGAQILTASERGFGKRTPLSKFPRRGRGGQGVIAMVTNERNGALIAAVQVQEGEEIMLISDQGTLVRTRVDEVSLSGRNTQGVTLIKLASDEVLVGLERVQEPSggDDEDLPEGEeaaeslGESAESESEPAAEAEGNEE----
>UniRef50_Q0W7S4(19-826:826) Type II DNA topoisomerase II (Gyrase), subunit A n=17 Tax=cellular organisms RepID=Q0W7S4_UNCMA  E=0 s/c=1.29 id=53% cov=92%
-----ETLLPVQIEEEMKRSYIDYAMSVIVGRALPDVRDGLKPVHRRCLYGMYELGNTHDKPYKKSARVVGDVMGKYHPHGDAAIYDTIVRMAQDFSLRYTLVDGQGNFGSIDGDGAAAMRYTEVRLERIAEEILADLDKETVDFAPNFDETLKEPVVLPARLPNLLINGSSGIAVGMATNIPPHNLGEIVDGTIAVIDNPEIEPIELLNYVKGPDFPTAGFIYGKEGIKEAYLTGRGSIRMRAKAEIVDE--NGKMSIIVTEIPYMVNKARLIESIADLVKDKKIEGISDLRDESDRDGMRIVIELKKAANANVILNQLFKHTQMESTFGVNNIALVDNTPMTLSLKETIGYFIKHRQEVVTRRSQFELKKAQAREHILAGLLIALTNIDDFVRIIRGSANADEAKATLMEK----------------------------------YGLSDEQSRAILDMRLARLTALERQKIDDERADLIKEIAHLNEVLASPQMVLDIIKAELLDMKAKYGDERRTKIVESAGEIVDEDLIPVENVVVTISNTGYIKRMPVDTYRTQRRGGVGIVGMETKEEDFVVDLFVASTHDNILFFSNKGKVYSLKVYEIpPAASRQARGKAIINLINIEPGEAINAMIPIKTFDDQHFLVMCTREGTIKKTALSAFQNIRSTGIIAIGLESGDELISVKMTNGSQEVLIATRNGKCNRFSESEVRTMGRPAMGVIGIRLTENDKVIAMEIVSPGQSVLTICENGFGKRTPIEEYTAHHRGGQGMINIKTTLRNGAVVAVISVMPDDQIVIASKEGMMTRMNVTDIPEIGRNTQGVRVMKMRPEDSVVAVARLVSEKKEDEI---------------------------
>UniRef50_Q2S0H7(1-877:910) DNA gyrase, A subunit n=1 Tax=Salinibacter ruber DSM 13855 RepID=Q2S0H7_SALRD  E=0 s/c=1.16 id=49% cov=97%
MEADDSRVIPINIEEEMKSSYIDYSMSVIVSRALPDVRDGLKPVHRRVLYGMHELGLTQGANYKKSARIVGEVLGKYHPHGDSSVYDTLVRMAQHFSMRYPLADGQGNFGSVDGDSAAAMRYTEARMTRIAEQMLTDIGKETVDTQENFDGTMEEPTVLPAAFPNMLVNGADGIAVGMATKIPPHNLGETIDATVAYIDDPDIEIDNLMDHLPAPDFPTGGIIYGYAGVYEAYHTGRGRVVMRAKMH-EEEVRSGRDALVVTELPYQVNKSREVERIADRVRQERIEGIADLRDESDRDGLRIVIELKQGANAEIVKNQVYKHSRLQDTFGVNMVALVGGRPQVVTLKDAIRHYVDHRHEIVVRRTEYDLAQAQDRAHILEGLTLALDHLDAVIAIIRHSPDTGTARQNLRAGRYPDALSDDDLRTINVPLTPPGEADEEQDTVqallgdeyeelvqqpDEGDWLTEAQANAILRLRLSRLTGLEREKIIGEYEDIIEQIREYQRILNSRDRRMALIKEELLTVKERFDDERRTEIDYtGGDDIIIEDLIERQHVVVTITNQGLTKRTPIDTYRTQGRGGVGMRGTGKREDDFIEHLYVCHSHDVLLLFTDKGQCFWLRPFEIPEGGRTAKGRSIRQLIDIDPDDRVRAVISVSKenfedeaFLNSHYVLAATRQGQVKKTALEAYSRPRSNGIIGIKIDEGDQLIEASLTGGDNTVVVASSGGRAVHFDEGDARPMGRNTRGVRGMELPGDQELVGMISVPpamhDDLDVLAIAEHGYGKRTALSDYRVQGRGGKGLITLNRTDRTGALVSIKGVLGDEDLMVITEGGIMIRTRVGEISTMGRNTQGVQVIDLKDGDAIADVTRVADTDEPEADDGT------------------------
>UniRef50_D0SBV6(2-981:993) Type IIA topoisomerase n=3 Tax=Gammaproteobacteria RepID=D0SBV6_ACIJO  E=0 s/c=1.02 id=62% cov=99%
-----SEIRPIAIEDELKNSYLDYAMSVIVSRALPDVRDGLKPVHRRVLYAMHELGNDYNKAYKKSARVVGDVIGKYHPHGDSAVYETIVRMAQDFSLRYQLVDGQGNFGSVDGDSAAAMRYTEVRMRKLTHEILADLEKDTVDWEDNYDGSERIPQVMPTRIPNLLINGTTGIAVGMATNMAPHNMTEVVNACLAYAENPNISIEGLMEYISGPDFPTGGIIYGKAGIVDAYRTGKGRLHIRGKYHFEEDQKTGRTTIVFTEIPYQVNKAKTIERIAELVKEKKLEGISELRDESDKDGMRIAIDLKRGENAEVVVNNLFQNTQLENSFSINMVCLDNGQPKLMNLKDIVAAFIRHRQEVVTRRTMFELRKARERGHILEGLTVALANIDAIIETIKTSANPAEARERLQAGEWAAGNVIALLEKAGSVSVRPDEIEGEdpsrpFGLDGQIYRLSPAQVGAILELRLHRLTGLEQDKLQAEYTEILGQIAELTAILNDFNLLMAVIKEELALILQQYGDARRTAIVESRIDFSREDLIPEEQVVLTVSKTGYAKTQPLSDYAAQRRGGRGKSATSMKEDDYIQHLIVTSNHATVLCFTNVGKVYRLRVFEVPQASRGSKGRPMVNLLPLDADETITAILPVIDAPkkfkerlaefknfvrsnvatlrensiidahydalkasfdelaedadelsdalrkqlkelgvelsttdldnetvvefadlaekmrKNFFVFMATASGTVKRVELEQFSNVRSNGLRAIELKEEDTLIGVAITDGEQQIMLFSNEGKAIRFSETDARVMGRTAKGVRGMRVtlaaaqTEDDvetdtdsddeessdlnvasRIVSLVVVPETGEVLCASANGYGKRTPVDDFPTKKRGGKGVIAIKTSERNGELVGAVAIDESKELMLISDGGTLVRTRASEVARTGRNAQGVRLIRLGNEEILVGVVAVEAVEVEDDI--LDASIETTEETVVDEVNVD------
>UniRef50_A8G5D2(12-858:865) DNA gyrase/topoisomerase IV, subunit A n=16 Tax=Cyanobacteria RepID=A8G5D2_PROM2  E=0 s/c=1.13 id=44% cov=92%
LSEDNDRIIQTDLRNEMSRSYLEYAMSVIVGRALPDARDGLKPVHRRILYAMYELGLTSGRPYRKCARVVGEVLGKYHPHGDTAVYDALVRMAQDFSMRMPLIDGHGNFGSVDNDPPAAMRYTESRLQSLTDEsLLEDIESETVDFSDNFDGSQQEPTVLPARIPQLLLNGSSGIAVGMATNIPPHNLGELINGLKSIIKNPSIEDRELFEIIKGPDFPTGGQILGREGIRETFKTGKGSITMRGVANIEQIKSIGRaekDAVIITELPFQTNKAALIERIADLVNEKKLEGISDIRDESDRDGMRIVIELKRDSYPQVVLNNLFKLTPLQNNFSANILALVKGEPTTLSLRKMLDVFLDFRVETIRRRTAFLLKKAEERDHIVKGLLLALDAMDEIINLIRSAKDSISAREKLQNEH----------------------------------KLSSIQSDAILQMQLRRLTALEADKIKEEHNELTRKINLYQQILNSKERIFEIILEELNQIDGKFSSPRKTEILDLGGGLDDIDLIANDRSVVLLTEAGYLKRMPVNDFESTSRGSRGKAGTKTKEDDDVKLFISCNDHDTLLLFSDRGVAYALPAYRVPMSSRTAKGTPSVQLLPIPREEKITSLVAVDSFVDDRYLLMLTKAGFIKRTALSAFSKIRSNGLIAINLEDGDALTWVRLSKEGDSVLIGSKTGIAIHFrlDINELRPLGRTARGVKSMNLREGDNLVSMDVLtsnlvdqlakiedltedlddnveensSDGPWVLIASAFGLGKRVPVAQFRLQKRAGMGLRAIKFRIKDDQLVCLKVLGEGEELLLVTEKGVIVRTNADKISQQSRAATGVKLQRLDDGDHLSEVVLVP-----------------------------------
>UniRef50_O83051(12-810:813) DNA gyrase subunit A n=6 Tax=Bacteria RepID=GYRA_TREPA   E=0 s/c=1.20 id=47% cov=91%
-------LVPISIETEVKRAYIDYSMSVIVSRALPDVRDGLKPVHRRILYAMEEKGLRFSGPTRKCAKIVGDVLGSFHPHGDASVYDALVRLGQDFSLRYPVIHPQGNFGTIGGDPPAAYRYTEAKMARIAESMVEDIKKETVSFVPNFDDSDVEPTVLPGRFPFLLANGSSGIAVGMTTNMPPHNLREIAAAISAYIENPNLSIQELCDCINGPDFPTGGIIFGKNGIRQSYETGRGKIVVRARFTIETDSK-GRDTIIFTEVPYQVNTTMLVMRIGELARAKVIEGIANVNDEtSDRTGLRIVVELKKGTPAQVVLNHLFAKTPLQSSFNVINLALVEGRPRMLTLKDLVRYFVEHRVDVVTRRAHFELRKAQERIHLVRALIRALDAIDKIITLIRHSQNTELAKQRLREQ----------------------------------FDFDNVQAQAIVDMQMKRLTGLEVESLRTELKDLTELISSLEELLTSPQKVLGVVKKETRDIADMFGDDRRTDIVSNEIEyLDVEDFIQKEEMVILISHLGYIKRVPVSAYRNQNRGGKGSSSANLAAHDFISQIFTASTHDYVMFVTSRGRAYWLKVYGIPESGRANRGSHIKSLLMVATDEEITAIVSLREFSNKSYVFMATARGVVKKVTTDNFVNAKTRGIIALKLSGGDTLVSAVLVQDEDEVMLITRQGKALRMSGREVREMGRNSSGVIGIKLTSEDLVAGVLRVSEQRKVLIMTENGYGKRVSFSEFSVHGRGTAGQKIYTQTDRKGAIIGALAVLDTDECMCITGQGKTIRVDVCAISVLGRGAQGVRVLDIEPSDLVVGLSCV------------------------------------
>UniRef50_Q2NAD1(5-927:931) Type IIA topoisomeraseA subunit n=30 Tax=Alphaproteobacteria RepID=Q2NAD1_ERYLH  E=0 s/c=1.03 id=48% cov=98%
----------IDIVDEMKTSYLDYAMSVIVSRALPDVRDGLKPVHRRILFASKEGGFVAGRPYRKSAKIVGDVMGNYHPHGDSAIYDALARMTQDWSLRVPLIDGQGNFGSMDPDPPASMRYTEARLAKVANALLDDLDKDTVDFSDNYDGSLKEPQVLPARFPNLLVNGAGGIAVGMATNVPPHNLGEVIDGCLAFIANPAITSEELMQYIPGPDFPTAPLILGQAGARAAYTTGRGSVLMRARHEIE-EKRGDRKSIVFTSIPYQVGKSGLVEKIADAAKEKRIEGISDIRDESSREGVRVVVDLKRDASPEVVLNQIWRYTPAQASFPANMLAIKGGRPEVLTLRDIVQAFVSFREEVITRRTKFELNKARERAHVLLGLVVAVSNLDEVVAMIRGSSNPQIAREKLRAKLWPIGDIAQYIQLI-------EAIEPTADQEGGTYQLSERQVKAILDLRLHRLTALGRDEIGDELKELASEIEEYLSILADRGKLFGVLQDELVEIKDEYATPRVSEIAPAWDGLEDEDLIAREDMVVTVTHGGYIKRTPLATFRAQARGGKGRSGMATKDEDAVVELFVTSTHNPVLFFTNLGRVYRMKVWKLPEGSPTTKGRPMVNLLPLGDDERVTNVLSLPEDEESwaaLNIVFATEQGMVRRNSMDAFTNVPTGGKYAMGFVEgtGDRLIGVELLSEDQEIFLASDAGKAIRFAATDARETkSRTGIGVRGMTLKDDAKVVSMAVLDrleqdmetreaylraaiwknndaehtldsdkvaqmeeGEEFILTLTANGYGKISSAYEYRTIGRGGQGLANIGTpdsnPERNGPVVASFPVKHGSQLMLVTDQAKLIRMPIefrhmveggfeehKGWSVYGRTSSGVRVFDVAKGEHIVGAAIIDETEEPENEAEEAVVEgmvGRGAEETAPDPTMDrDSNEGE
>UniRef50_B2URM6(4-873:873) DNA gyrase, A subunit n=5 Tax=Verrucomicrobia RepID=B2URM6_AKKM8   E=0 s/c=1.10 id=45% cov=97%
------RIKPVDVASELSTSFLDYSMSVIISRALPDVRDGLKPSQRRILYAMKELNLSPGGKTRKCSKIVGDTMGNYHPHGDAAIYGTLVNMAQDWSMRDILVIGQGNFGTPDGDPPAAARYTEAKLSGMGVALMADLDKDTVDFVPTYDNEHTEPTVFPSAFPNLLVNGGTGIAVGMATNMPPHNLGEVVDGICAVIDNPHMTVEELRQYIKGPDFPTGGDVLGFSGIDNYFRTGRGSVRIRGKIDMEV-TDSGKDLLIIREVPYGVNRAALQERIAELYKDKILTDISGIRDLSD-EKTCIEIELKRDARPQVVMNQLYKLTSMETSFAVNMLAIHDNRPKTLAMMDAINFYIEHRREVVVRRTRYLLGDAEKDAERLEAFLLALHHMDDFISIIRDSKNRDEARERLQNYTFSTQTAESLGILIRSQASIQ----------GDRYVFTERQVNSILDLRLYQLTALENDKISGEYAELLVRIKDYLDILANESRVLGIVKDELKAIKDKYATPRVTRIIPFSGDMAIEDLIPNDTMIVTITHSGYIKRTNSAEYRVQARGGKGVKAATTRgakkdaEADFIEHLFAAQNHDYLMFFTNTGRVYVDRVYEIDEAARSAQGRNIKNLLDLQPEEAIAAILRLERRVDEKgnditfaegsgNVVFATKDGTVKKTSLNDFANYRKAGIIAINLEEGNSLVNAELTSGADEIVLVTHDGMSIRFPEEDLRTQGRNTIGVRGIRPRAGDYVVALAIVDPQKTLLVASENGLGKRTSFDEYRTQGRGGTGIKTMNCTDKTGKVVSATVVSDEDELMLMTTAGQSVRIKVATVRETGRATQGVKLMTLNEGESIQDISIVIPDDEDEEAP------AETEDAGAGEVSGEmEAPAEE
>UniRef50_B6BPL3(10-854:859) DNA gyrase, A subunit n=3 Tax=Bacteria RepID=B6BPL3_9RICK   E=0 s/c=1.10 id=45% cov=94%
------NIKLISMHDEMSSSYLSYAMSVIVSRALPDIRDGLKPVHRRILYAMYKGGYDWSKQFRKSARIVGDVIGKYHPHGDQSVYDALVRMVQDFSMSLPLVQGQGNFGSIDGDPAAAMRYTETRLSKVSQYLIDDIEKNTISFKSNYDETEKEPTVLPAQYPNLLVNGAGGIAVGMATSIPPHNLGEIINGTLALIDNKDIKIRELMKYVPGPDFPTGGVIIGKDIIKHGYNNGRGSFKIRGEVSVE-SLKNGRERLVITSIPYQVNKSVLNERIAQLVREKKIEGIKDIRDESNREGIRVAIDLRNGVEPETIKRQLYKNTQIESSFGFNTLAIVQGKPKTCTLKDFLSNFLSFREDIVIKKTKFDLQKAEERAHILIGLSVSVENLDKIIKIIRSSKTPEDAKQAILKTKWKINKSQKLISLVEGKKGK------------GLYSLSEPQVIAILELRLQKLTALGINEIEVEIKKLAELIARYKKIISSKKELLKVISEELKNIKEKFAVPRRTKIIDAVLNYDIEETIQKQSVIITVTLQGYIKRGSLDGVKQQKRGGKGKSGITTRDQDSVVQTLSVNTHTSVLFFSTEGLVYKVKAWKIPEGSSSSKGKSLFNILPLKSHQSISSIMPMPENETDLKnyqIIFATAQGKVRKNSLEDFSSINASGKIAMKLDNNDKIVGVKICQDDQDIILSTKFGKCIRFEAKKLRVfKGRSSKGIKGIELAPNDQIVSLSVIDNDktkkngkkskddkseikakeKFVLSISENGYGKKTSHIDYRVTNRGGKGIIGIVNSPRNGNITSSFPVFEGDEILISTNKGRVIRVAVKEIRTAGRNTQGVRIIKLSGEEKVVSAIKI------------------------------------
>UniRef50_B8BXG7(1-818:820) DNA topoisomerase IV, ATP/GTP binding site n=1 Tax=Thalassiosira pseudonana RepID=B8BXG7_THAPS  E=0 s/c=1.13 id=42% cov=91%
---------------------MQYALSIILGRALPDARDGMKPVHRRILYAMNGLGLSPSGSYRKCARVVGEVLGKYHPHGDTAVYDALVRLAQPFSTNIPLIDGHGNFGSIDNDPAAAMRYTECRLTRIaAETLLDDILMDTVEFLPNFDGSEYEPSVLPAKVPILLLNGGAGIAVGMATNVPPHNLGELMDACVALTKgrnegGEEVTDGKLLQIIPAPDFPTGACIIGKSGSRSLYTTGNGGVVMRAVMHLEEvptssgKKKSTRNAIIVTELPYQVNKAALLERIAILVNEKKLEGIADLRDESDRDGIRMVIELKRDAVAAVVQNNLLKKTSLQTTFSGNFLALFGGgtNPQRFTLREALDCFLDFRFQTIRNKCAFQLDKVENRAHIVAGLLIALESTDEVIAIVRNAPDQASARAALM------------------------------STDNPKLGLSSAQADAVLKLQLGQLTRLNGDKLNDEKKTLDESQTNLRNLLTNDAAVRDTMLEEFMAMKKRFGTPRKTKILPDEEDKADIDLVQNERSVIVVTRGGYIKRMPLKTFESQNRGTRGKRGTSntISDDNAVAHCFTCNDHDTVLMTTQSGVAYGLRAYQVPEGGRTARGAPIPSVLPVKSDDVITSVLPVSEFSKNEFIVLATEYGWIKKTPLAAFEKLTQRGLIIATLADGDRLNWCEKCTDNDDILVGSTRGQATRFKAADLRPTARTSRGVKSMTLKKGDTIADMNVLrKEDKFVLVVTTEGYGKRVLTEEFRTTARGGSGVIAIKFKAGrvDDRISTMRVVNEDDEILLITSQGVIVRQKVSDISCQGRAATGVLVqkVDVRSGDSISTVSIVPKEDADGDV---------------------------
>UniRef50_D1AVF2(43-859:870) DNA gyrase, A subunit n=1 Tax=Streptobacillus moniliformis DSM 12112 RepID=D1AVF2_STRM9  E=0 s/c=1.12 id=50% cov=91%
----------IYIEDEIKASYLDYSMSVIVSRALPDVRDGLKPVHRRILYAMDELKMNHNSPYKKSARLVGEVLGKYHPHGDSAVYNSMVRMAQDFNTRYMLVDGHGNFGSIDGDSAAAMRYTEARMSKIAEEMLIDINKDTIDWRKNFDESLDEPTVLPARLPNLLLNGTTGIAVGMATNIPPHNLGELSDGIIALIDNRDISIDELITHIKGPDFPTGGIIYGKSGIYSAYKTGRGKVRVSAKTEIITDKK-GRQSIVITELPYQVNKANLIKRIGELVKDKIIVGISDLADLSNLEGIRIVIDIKKGEEAEIVLNKLLKFTDLQTTFGIIMLALVNNAPKILNLKEILEKYLEHRYDVITRKTIFDLNKAKDRAHILEGLRKALDHIDEIISIIRGSKTRALAKESLIAK----------------------------------FEFTEIQTDAILDMRLHRLTGLAREEIDTEYDKLMLFITDLEDILAKDERKYAIIKEEVLELKQKYGDARRTSIENDRYEINIEDLIKNEDVIVTITKRGYAKRMSLDSYKAQKRGGKGVSNTTTIEDDVLKDLFTAKTLDTLMVFSDKGKVYSIKVYEIPEVSKQARGKLIGNIIELDENEKISVIIPVDEIENDnRDLIFITRNGIAKKTKISEFKTINRNGKIAISFKDDeDEVKFVGITSGSekDEIFISTKGGMAVRFKEEDIRSMGRTAAGVRAIKLNSNDEVVSADVIYTDNNvdemsVLSVTSLGIGKKTLLSEYNIIKRGGKGVKNYNLERRskeeseHHYVVYSTIIDPSDensenmELVAISTTGTVIRIKIKDLPVVGRNSKGVKIQSLKYKEYLVSADRVA-----------------------------------
>UniRef50_D1JED8(8-839:843) DNA gyrase subunit A n=1 Tax=uncultured archaeon RepID=D1JED8_9ARCH   E=0 s/c=1.10 id=48% cov=91%
--EVRERVIEVSVEDEMTHSYMDYAMSVIVGRALPDARDGLKPVHRRILYGMHELGVTHNRPHKKSARIVGDVLGKYHPHGDVAVYDTMVRMAQDFSYRYPLVDGQGNFGSVDGDAAAAMRYTEARLSKIAGELLVDLEKDTVEWSPNFDNSLKEPQILPAKLPNLLINGSSGIAVGMATNMPPHNLTEVVDGVIRVIEEPEVSIEELMQIIKAPDFPTGGIIIGYEGIKRAYETGRGSIRIRAKAEIEVKGK--KERIVINEIPYQVNKSRLVEEIAEFAKKYKVESISGLRDESDRKGMRIVIELKAGANSAIILNRLYKHTQLENTFGVINLALIDGEPRVLTLKELIECYIKHRKEVTIRRLQYELERAEKRLHILKGLIIAISNIDEVIRLIKAASDTKTAKSALIAR----------------------------------FELSEEQAKEILDMRLSRLSALERDKIETERAELETKINWLKEVLGSEARIYELLKEDLIEQKDKYGDARRTNI-EEMVTLSERDFVEEKEVILYLTQRDYVKRLPADIFKQQMRGGKGIAVIEKKEDDKIVNFIRASTRERLIFFTEFGKAYQVKTYEIPPSSRHSKGKPLVNIpglsISTEEREKFVTAVAIPEevdkgietNTEGAYLVFATKRGVVKRSSLAKLKAIRSTGVVAVRTTKGDSLADVVLIKpsldsqdrgaGQNGIILSSKNGKAIFFHEEELREMGRYAAGVRGMRLEKDDEIASVEaldvgVSKEKSRAVTITEKGYGKRTKLDAYRETHRGGKGVISIKTGERNGKVVCIKQVKNTDELMVATSDGMVTKISVRSISVQGRNTQGVRIMNVKKGERVVAV---------------------------------------
>UniRef50_C7M119(9-811:816) DNA gyrase, A subunit n=1 Tax=Acidimicrobium ferrooxidans DSM 10331 RepID=C7M119_ACIFD  E=0 s/c=1.14 id=44% cov=92%
----ASNVELIELQEEMERSFLEYSLSVIIARALPDARDGLKPVHRRILYSMYDAGYRPDRPHVKCAKVVGDVMSRFHPHGDAAIYDALVRMAQDFSLLHPLIDGHGNFGSPDPStGPAASRYTECRLAPIALELLAGIDEDTVDFVPNYDSQTVEPSVLPARFPNLLVNGSQGIAVGMATQIPSHNLGEVVDAIAYLIDHPEATVDELMRFVPGPDFPTGGIILGRDGIRDAYRTGRGSVKLRAVATIEE--ARSGYQIVVTEIPFQTSVEVIADKIRHLVEEKLLEGIRDMKNFSAGSETRFVIELKRDANPNVVLNNLYRLTPLQTSFPIQMLALVDGAPRTLNLLGLCQIYVDHQREVIRRRSEFRLGKARERLHIVEGLLSCIDQLDAVIATI---------------------------------RASEDRAAARAALMAEPFGFSELQANHILDMTLGRLTRLGREELEEEAATLRATIAELEAILADAQRLSAVVKDEMLAATAEYRQARRTRFEVDPGDFAAEDLIEDEPIVVLISRSGYIKAVPESSFKAQGRGGRGVVGARVKDEDEIAHVISSSMLSRLLVFSSRGRVYQLRGYELPKLERSARGTALVNLVPLADDERITSVMGTKDFPEDADLVFFTRNGMVKRTAMAEYARSRRDGIIAIDVRGDDELVSVVVATEEHDGVVFTKRGQVLRFPLAEVRRTGRATAGVRSIRRADGDWIVAGGLIEDGVEVLLVTSRGYGKRTPLDSFPVHHRGGAGIRGIGLTERKGELVAAAFVRPEDEVLIVSSQGQMIRVRIGDISNQGRYATGVKLISLQAEESVASVGVVPE----------------------------------
>UniRef50_B5RLZ1(8-815:815) DNA gyrase, subunit A n=5 Tax=Borrelia RepID=B5RLZ1_BORDL   E=0 s/c=1.10 id=42% cov=91%
-----EQVLNIKIEDEVRTSYLNYAMSVIVSRALPDVRDGLKPVHRRILYSMHEMGLKSDKSFKKAGRIVGDVLGKYHPHGDQSIYEALVRLAQDFSLRYPIVSGQGNFGSIDGDPPAAMRYTEARMAKIAEELVIDIDKQTVNFKPNYDDSLLEPEVLPAAFPFLLVNGSSGIAVGMATNMAPHNLREVCDAIIYMLEHDDVSIYDLIAIIKGPDFPTYAEIIYNENLIKAYTTGKGSVVIRARYHIEEKSE-DNISIIITQIPYAVNKSSLLMKIALLIKEEKLEGVSDIRDESDREGIRIVLEIKKGFDPHVVMNLLYEYTELRRNFSINNLALVNGIPKQLNLRELISEFIEHRKNILRRRVEFDLKRAQEKAHILEGLNIALRNIDRVIEIIRFSRLVKDARECIMRE----------------------------------FQLSEIQANSILDMKLQKLTSLEVAKIEEDFQVVLALIKDYEDILISPSRIVNMIREEIINLSLKFGDDRRTKIIYDEEvlKTSMSDLMQRENVIVILTKQGFIKRVLQDEYKLQGIGGKGLGSFDLQDSDQVNVALCVNTHDFLLMISNEGKLYVINAYGIKDSSRTSRGQNIRELINLGEKEEILAIKNCSELSVDNYLLITTANGKIARIETEGFKTVKSRGVIIMKLDDKDFVTSAEIVSRDDKIICISKKGNAFAFSSNDIRLTHRGTQGVSGMKVREGDMLIKALAIKQGSHLLIMSENGYGKRLEVSKVTGLKRGSTGYTCYKKSdEKAGEVVDAITVSQDDEILLISKSSKVLRTLVDKISEQGKDARGMQVLSLDE-DKLVAVSK-------------------------------------
>UniRef50_Q2ST76(1-794:795) DNA gyrase, A subunit n=7 Tax=Mollicutes RepID=Q2ST76_MYCCT   E=0 s/c=1.04 id=45% cov=90%
-------------------------MSVIVSRALPDLKDGLKPVHRRIIYAMNDLGITSDKPHKKSARIVGEVIGKYHPHGDSAVYETMVRMAQEFSYRYPLIDGHGNFGSIDGDGAAAMRYTEARLAKISNYLIKDIDMDTVPFIDNYDASEHEPAYLTGYLPNLLVNGTMGIAVGMATSIPPHNLKEVVSAINAYIDNNDITIDEILDnHILGPDFPTGALMTNGSKMREGYKTGRGSVIIRAKIDFEENKKHDR--FVVTEIPYQTNKAKIIEKIAELVKDKTIEGIFDIRDESNYEGIRIIIELKKDANPDVVLSKLYKYTALQSSFSINLLTLNNNLPVLLDLKTIIKNYVEFQVNVIIKRSIFEKNKLTKRYHILEALHIALDNVDDVINIIKNSKTSEEAKIQL----------------------------------TNKYNFDEEQNKAILDMRLQRLVGLERDKITLEMTNIKERLTYLDILINTKEEQNNVLKNQLNEIADKFGDNRRTELIDEElINIEDEELIPDLKWMILLSQEGYIRRINPDEFRIQKRGGRGVS-VNAEPNDPIDIATMGKAKDWVLFFTNSGKVYRTKLYNIRSYSRTARGLPIVNFLNdLTSEDKITAILPLRNNKEKfNYLTFVTQKGMIKRTKISEFENINRNGKKAINLRENDQLVSVFATTGQDTIFIANESGKVIRIKESVVNPQSRVGSGVRALKLETNDVVVGAISSFKLTHITTVSNKGLFKKTPIDDYRISGRNGKGIKVMNLNQRTGKFKAIIDARETDLILIISSDGNLIKTKVSNIPSLSRNASGVKAIRLADNQEInaITLEYRKHGLENEDFEE-------------------------
>UniRef50_B5Y886(4-752:758) DNA gyrase, A subunit n=1 Tax=Coprothermobacter proteolyticus DSM 5265 RepID=B5Y886_COPPD  E=0 s/c=1.08 id=41% cov=86%
-------IHEREITEELKQSYIDYAMSVIVGRALPDVRDGLKPVQRRIIYSMSETGSTYNNPYKKSARIVGDVLGKYHPHGDASVYDALVRMAQDFVMRYPLVDGHGNFGSMDGDPPAAMRYTEVRLTRLSEYLVQDLDKDTVNWVPNFDGSLKEPEVLPAVFPQLLVNGSSGIAVGVSTYIPPHNLGEIIDATLHFLHNPEATSRQLMRFVKGPDFPTGGQIINPQDLVKVYEEGKGVIRVRGRAKLE-EGHGQKRRLVIYEIPYMVNKAELVSQIAQLIRDRKLSGVDEVRDESNRQGVRVVLELKKGASFHHILNQLYEQTALENSFAINMVALKDGAPVQLTLRDYIASFVDFRKETILRRTRYLLDKASKRREVVEGILKALDNIDLVIEIIRNAETTDQAKRRLMSQI----------------------------------GLTEVQAEAVLEIKLRSLVHMEKEKVEQELESLLKAIAEYTEILNSETKLLEVIAEELKHVKKLFADQRRTLIGFSDQQTETVQ-AAEETFFIELLEYGIIRRSKTQT--------------------NLVDFIEVQGSDPVMFLTNFGKIFCISAYEIPESQR---GVALNALFPMGNDEKVLLLGT-----QNQELIAISEKGKGKRFRL-DVEKIPSRGGYYFLLDPGD-MVSVIVPVTSKELVVISAQGKALRLDVESIPERGLRTGGVKVMRTYEGDRVVGATCLK-QKYIVTMTENAYAKRTDIDEIPKRNRGAAGVFIHKANETTGPVIGV----SCNENMLYRSGREWLPLSMSDIPVCSKASMGKKVLRT------------------------------------------------
>UniRef50_Q5MZD4(8-850:858) DNA gyrase A subunit n=8 Tax=Cyanobacteria RepID=Q5MZD4_SYNP6   E=0 s/c=0.95 id=38% cov=90%
----ADRILPTALHQEMQRSYLEYAMSVIVGRALPDARDGLKPVQRRILYAMHELGLTPDRPFRKSARVVGDVLGKYHPHGDQAVYDALVRLVQDFSSRYPLLAGHGNFGSIDNDPPAAMRYTETRLAPVSHvALLEEIGEETVDFVANFDNSQQEPSVLPAQLPFLLLNGCSGIAVGMATNIPPHNLGEIVDALIALIDRPQLSDRDLLRYVPGPDFPTGGEVIGSQGILDAYLEGRGSIPVRGIARIEEiqpgKGRHRRPVIIVTELPYQVSKAGWIEKVADLVNDGKLQGIADIRDESDREGMRVVIELRRDAQADKVLEQLYKRTALQSNFGAILLAIVEGQPQQLSLKQLLEQFLSFREGTLRRRYGHELEQTERRLMILEGLLRSLSDLDGLIEILRQSPDGGTARARLQVH----------------------------------FDLNERQADAVLSMPMRRITSLEQEQLQQEAANLREQQARLQTLLGDRPTLLKALKKDLRDLKRRFGSPHRTRlpeippeaiaaprqvtapvapisaptpatagpiqgelIFNSATDSAVPDSAPviaprfafQESTWLCLSDREQLQAASATELEPWLKAKSGAQERT----DFPKVLQWADPRQDLLVITAEGRAYRRSLREVHPG-------PIANLLPTgRQSTAIAATLLLPLASEERSLLPLSSQGRVKRLALTELAEISNRGLQLLKLAEEEIIQAACLCAPQQEVLLGSSGGRLLRLSLSELPLASRISRGqPRLLRLREGEQPLGCLSLPSGQDLLLVSTLGLVKRLPLGLLRLCRAGDLGNNAFRFTDKRDRLIALLPAPSQGLAIFASDQRLWQR-SISTIAVTGTDAEGQTLFNLRSTETLQSATTL------------------------------------
>UniRef50_C9Z0I9(16-771:818) GyrA-like gyrase subunit n=9 Tax=Actinomycetales RepID=C9Z0I9_STRSW   E=0 s/c=1.04 id=40% cov=83%
-----ERILDIDVVDEMQGSFLEYAYSVIYSRALPDARDGLKPVHRRIVYQMNEMGLRPDRGYVKCARVVGEVMGKLHPHGDSSIYDALVRLAQPFSMRLPLVDGHGNFGSLGNDDpPAAMRYTECRMADATSLMTESIEENTVDFSPNYDGQEQEPVALPAAFPNLLVNGASGIAVGMATNMPPHNLGEVIAAARHLIRYPNADLDTLMKHVPGPDLPTGGRIVGLSGIRDAYATGRGTFKIRATVTV-DNVTARRKGLIVTELPFTVGPEKVIAKIKDLVGAKKLQGIADVKDLTDRaHGLRLVIEIKNGFVPEAVLEQLYKLTPMEESFGINNVALVDGQPLTLGLKELLEVYLDHRFEVVRRRSEFRRGKRRDRLHLVEGLLTALVDIDEVIRLIRSSDNSAQAKERLIER----------------------------------FALSDIQTQYILDTPLRRLTRFDRIELESEKEKLNTEIAELTRILESDAELRKLVSGELAAVAKKFGTERRTVLLESSGTqvAAVPLQVADDPCRVLLSSTGLLARTASAEPFTADEDGR------RTKHDVIVSAVPATARGEVGAVTSTGRLLRLNVVDLPQLPDTSAapnlsgGAPLAEFLTLQDGETLVCLMTLDESSPG--LAIGTEQGVVKRV-VPDYPSNKEE-LEVISLKEGDRIVGaVELRTGEEDLIFITDDAQLLRYQAAQVRPQGRPAGGMAGIKLTEGAKVISFTAIDPAVDAVVFTVAGSrgtlddsvqttAKLTPFDQYPRKGRATGGVRCQRFLK-------------------------------------------------------------------------------------------------
>UniRef50_A8UVW0(12-781:781) DNA gyrase A subunit n=1 Tax=Hydrogenivirga sp. 128-5-R1-1 RepID=A8UVW0_9AQUI  E=0 s/c=1.00 id=44% cov=84%
----------------VKQSYIDYAMSVIVGRAIPDVRDGLKPVQRRILYAMYEMGLMPEKPFKKSARVVGEVLGKFHPHGDQAVYDALVRMAQDFSMRYPLIIGQGNYGSVDGDPPAQMRYTEAKLSKVAVELLEDIDKDTVDFIPNFDESLMEPAVLPSKFPNLLCNGTAGIAVGLATSIPPHNLREVGKALVELAKNPNMSTEEILEIVKGPDFPTGGVIENYKDIKEIYETGRGIVQVKAKAHVE-KVQGGREQIIVSEIPYQVNKAELIKKIADNVRSGRLKEISDIRDESDKDGIRIVIELKREAKGEKVLKKLFKYTQLRKGFPVNLVVLINGEPKLVGIKELLREFIKHRLSIILRRTRFFLKKAEDRLHVVQGLLIALNNLDEVIEGIRRSKDVQEAREMLQAR----------------------------------FGLTERQAQAVLDLRLHRLTSLERDKLRQEEADLLQKIEYYRKVVGSEEERIKIFVEETENLVKKFGDPRRTFIEGIEEKIEEGSLV------VAVLENG--KVMPVENMPEGESPVVDILDVPFTEG--------------LFLVSNRGRVYWLAGSQALQGSKVNF---------KESEEYIVGAFIRERFAD--RLLLATRNGMIKKIPLVEFE-YKAQGMRIIKLAEDDEVVGIAQSIDMSDILMFTRRGKVARFSIREIPAATPGTKGAQGIKVEDNDEVAGARVIREDQpYIIVVTVDGKVKRIYQQEIGVRNRGVKGVNVLGSARE--RLVDLLPIKDELELLITTKLGRAFydRIRAEDIPLSKRD---------------------------------------------------------
>UniRef50_Q04F36(1-810:811) DNA topoisomerase IV subunit A n=1 Tax=Oenococcus oeni PSU-1 RepID=Q04F36_OENOB  E=0 s/c=0.93 id=36% cov=82%
MTD-ESRIQELSLEDVMGERFGRYSKYIIQERALPDIRDGLKPVQRRILFAMNEDGNTYQHAYRKSAKAVGNVMGNYHPHGDSSIYDALVRMSQNWKMREPLIDMNGNNGSIDNDPPAAMRYTEARLSMIAGDMLTDLDQQAVDMVLNFDDTRYEPTVLPSRIPNLLVNGASGISAGYATEIPPHNLGEVINALIYLLSHPAASLEDLMKYVSGPDFPTGGIIQGLDGIKNAYTTGRGKVYLRAKTEIK-QLRAGKKQIEITELPYEVNKSELVARIDEIRLNKDVNGITEVRDDTSREGLLIAIELSKDANAEGILDYLFKKTDLQIAYNFNMTAINKQRPVSVGLKQALSAFLDFRKEVIRRRTEFELKKAQARQEIVEGLIKMLSILDEVVATIRGSESRKNAKENLIKK----------------------------------FQFSDPQAEAIVTLQLYRLTNTDVVALQNEHDRLTKQISEFNSILKETKELNKVLRNELKEIEKKYSNPRRSQIQTEVSqlKIDTAVMIANEDVIVQITKNGYAKRASFRSYKATDDNG-------LTDDDYPVYLAKVNTLSSLFIFTNKGNLIYRQVYELADTKWKDVGEHLSQEISgLAEDEIVIKVFDFKDLKQTGTFVFTSSDAFVKqvdKNALNPTKYYKKRASKAIAIKGKNVLVSVAFAASQNHLVVmATQKGYLYKFPIGEIALMTAKSSGAKPAKISKKDRIVSMDLIDSEDLMVLMSDRGHSKIINPLEIPI----------------------------------------------------------------------------------------------------------------
>UniRef50_A8LLG0(26-721:777) DNA topoisomerase IV, A subunit n=23 Tax=Alphaproteobacteria RepID=A8LLG0_DINSH  E=0 s/c=1.06 id=41% cov=78%
-------------------RYLQYALSTIMHRALPDARDGLKPVHRRILYAMRELRLSATGGFRKSAKISGDVMGNYHPHGDAAIYDAMARLAQDFNVRYPLVDGQGNFGNIDGDNPAASRYTEARLTAAAEALMEGLAENAVDFRDNYDGTLTEPEVLPAAFPNLLANGSSGIAVGMATNIPPHNLHELIDGCLHLIRAPNARDETLLEMIPGPDFPTGGVIVEpKESIAQAYATGRGAFRLRARWARE-DLGRGQWQIVITEIPYQVQKSKLIEKIADLIQTKKVPILADIRDESA-DDVRIILEPRsKNVDPEVLMGTLFRLSELETRFSLNMNVLIDGRtPKVCSLREVLRAFLDHRRDVLGRRSRHRLAKIDHRLEVLEGFLVAFLNLDRVIDIIRYDEDPKAA---LMREDWSLKHVRATDEADYKTPAPGEGE------------LTEVQAEAILNMRLRSLRRLEEMELISERDALMAERAELEDLLADEALQWARIADELREVRKQFGKgtalgKRRTDfaVATEMAEVSLEDMIEREPITVVCSKMGWIRAM--------KGHVALDQALKFKDGDEGRFIFHAETTDKLLAFGANGRFYTLSCAALPGG--RGMGEPIRLMVDLPNEAELVDLFL---HVPGRRLIVASDAGDGFIVPETEVLAQTRTGKQVLNVKSPHRALLARPVAG-DAIAAVGENRKLLVFAADELPEMGR-GKGVRLQKYKDG--------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A6CC19(21-797:802) Type II DNA topoisomerase, A subunit n=3 Tax=Planctomycetaceae RepID=A6CC19_9PLAN  E=0 s/c=0.94 id=35% cov=86%
----SDRIEYVPISDVTRRRYLNYAMSVITSRALPDVRDGLKPVQRRILYVMyHDLRLMANAKPRKCAKICGDTTGNYHPHGDASVYDALVRLAQDFNLRSPLINGQGNFGSIMGLPAAAARYTEARLTGIAEHLMNELRYQTVEMRPNYDGTRDEPVVLPARFPNLLVNGVHGIAVGMATNIPPHNLGEVIKACVHLIHHDDATVAQLMKHIKGPDFPMGGRIVtDKRSLTAVYKEGRGPVKVRGEWKPEPGTRTkGVQRLVVYSVPYGVETGSLLSEIGGIVESRKLPQLVDVADETdDKNGLKIVLEIKPDADPETVMAFLYKHTNLEQNFSVNMTCLVPDEsevlvPRRCDLKEMLQYFLDFRFISVRKRFEYQLQLLERRIHILKGFAIIFNDLDKALKLIRASSGKQDAAKKLMAN----------------------------------FPLDEIQTMAILELQLYRISKLEINTIREELAEKEAEAEKIRKILASDKRLWKVVENELKELADEFPEKRQTKLgsSEEITEFDPQAYIVRENTNVVVSREGWIKRV---GRLKTKEGTQELAKTRTREGDSVLAVAPGSTLDHVVFFSSDGVAYTLPIEQVPVSS--GYGEPLSKHARMSDGAVLVAAVTTDSrFTPEdkatkkqplptPHVLIVTEKGQFMRISFSLFRTASTKaGRKYCRLGKDDRVVYAGLVEEAETMFIATQDARVLHCEIEEAALLSNAGKGVKGIRLEKGDQVIGVLqLTRPSDCLRVINTAGKKMTFGQMKYGVTSRGGKGVKTSQRSGFAEILYPPIEVVDWDEL--------------------------------------------------------------------------------
>UniRef50_O52166(9-748:933) Topoisomerase IV subunit n=2 Tax=Mycoplasma hominis RepID=O52166_MYCHO  E=0 s/c=0.96 id=33% cov=84%
IQEVTENIIEKNMADIMSDRFGRYSKYIIQQRAIPDARDGLKPVQRRILYSMWNLHLKNSEPFKKSARIVGDVIGRYHPHGDSSIYEALVRMAQDWKSNFPLIEMHGNKGSIDDDPAAAMRYTESRLEKISELMLKDLDRKVVKMAPNFDDSEYEPIVLPALFPNLLVNGAKGIAAGFATEIPPHNLGEVIDATIALIKNPTISIEELSEIVKGPDFPTGAIINGINEIKKALSSGQGRITISSKYHYVYDKKDESKiiGIEIIEIPFGVVKSKLVADIDAIAIDKKISGIKEVLDQTDRNGISIFIQLEDGANADAIIAYLMNKTELSISYSYNMVAIDNNRPVILNLYSALIAYLSHLKEVNINGINYDLKKFKLRLEIVEGFIKVAEISDEVIHLIKESDNSK---------------------------------KGVILALMNKFKFSELQATAIAELRLYKLSRMDQIEFQEEKKNLEIQIENCNKLLNDKWEFNQYLIKQLLEIKNQYSKPRLTEISDQKIDkeIDHKLLTKNEDFYLYITKDGYYKKISLKVYTSNE-----LSTFKLKEEDNVFYFDKVNSLSKILFFTNLGNYFIIDCHLFKDCNWKDLGQHISSIVALESSEKIIRVIEITSFNNYANFILMSKLGYAKKVNLRDFENKSSlKTKTCMSFKDDnDELIDAQISNDEKMLFILLNNGMYHLVSENELKVgISLKARGIRlLLNLykHPQLQVSGFITVSKYNNIIYLTQGGYIKCWDTSKLESTTRNT-----------------------------------------------------------------------------------------------------------
>UniRef50_Q9HUK1(5-751:754) DNA topoisomerase 4 subunit A n=318 Tax=Proteobacteria RepID=PARC_PSEAE  E=0 s/c=0.92 id=38% cov=77%
----LEGVERRSLAEFTEQAYLNYSMYVIMDRALPHIGDGLKPVQRRIVYAMSELGLDADSKHKKSARTVGDVLGKFHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDpKSFAAMRYTEARLSRYSEVLLSELGQGTVDWVPNFDGTLDEPAVLPARLPNLLLNGTTGIAVGMATDVPPHNLREVASACVRLLDQPGATVAELCEHVPGPDFPTEAeIITPRADLQKVYETGRGSVRMRAVYRVEDGD------IVIHALPHQVSGSKVLEQIAGQMQAKKLPMVADLRDESDHEnPTRIVIIPRSNrVDVEELMTHLFATTDLETSYRVNLNIIgLDGKPQVKDLRQLLSEWLQFRIGTVRRRLQFRLDKVERRLHLLDGLLIAFLNLDEVIHIIR---TEDQPKAVLMER----------------------------------FELSEVQADYILDTRLRQLARLEEMKIRGEQEELLKEQKRLQTLLGSEAKLKKLVREELIKDAETYGDDRRSPIVarAEARALSETELMPTEPVTVVLSEKGWV--------RCAKGHDIDAAGLSYKAGDGFKAAAPGRSNQYAVFIDSTGRSYSLPAHSLPSA--RGQGEPLSGRLTPPPGASFECVLLP---DDDALFVIASDAGYGFVVKGEDLQAKNKAGKALLSLPNGSAVVAPRPVRDveQDWLAAVTTEGRLLLFKVSDLPQLGK-GKGNKIIGI-PGERVAS---------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A1TLU5(22-769:785) DNA topoisomerase IV subunit A n=22 Tax=Betaproteobacteria RepID=A1TLU5_ACIAC  E=0 s/c=0.90 id=39% cov=76%
-----------------QRAYLEYALSVVKGRALPDVCDGMKPVQRRILFAMERMGLAYGGPTRnvpakpvKSARVVGDVLGRFHPHGDQSAYDALVRLAQDFSQRYPLIDGQGNFGSRDGDGAAAMRYTEARLTRIASLLLDEIDQGTVDFVPNYDGSTEEPRQLPARLPFALLNGASGIAVGLATEIPSHNLREIADACVALVKNPKLADEELAALVPGPDYPGGGQIISSPGdIQDAYRTGRGSLKVRARWKIE-DLARGQWQMVVTELPPGVSAQKVLEEIEELTNPKvkagkkalsqeqtqlkaTVLGVLDvVRDESSKDaPVRIVFEPKTGRVPQQeLITTLLAHTSLETSAPINLtMVGLDGKPVQKSLRRMLEEWIAFRQQTITRRSQHRLAKVLDRIHILEGRQTVLLNIDEVIAIIRASDEPKAA---LIER----------------------------------FRLSDRQAEDILEIRLRQLARLEAIKIEQELKELREEQGKLEDILANPASLRRLMVKEIEADAKQFADARRTLIQADKRA-TAEVKVVDEPVTVVVSQKGWV--------RARQGHGHDAGTFAFKSGDALYGTFECRTVDTLIAFGSNGRVYSVAVSQLPGA--RGDGQPITTLIDLEAGTQPVHYFAGP---ANAALLLAGSGGYGFIAAVEHMTARNRGGKAFVSLGEGEQLCrpsHAAFTSGSQplapatHVCCASAGGRILTFEITELKQMANGGRGLMLIDLEPKDTLAGA--------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_P48374(22-752:768) DNA topoisomerase 4 subunit A n=17 Tax=Betaproteobacteria RepID=PARC_NEIGO  E=0 s/c=0.90 id=36% cov=80%
-----------------ERAYLEYAMSVVKGRALPEVSDGQKPVQRRILFAMRDMGLTAGAKPVKSARVVGEILGKYHPHGDSSAYEAMVRMAQDFTLRYPLIDGIGNFGSRDGDGAAAMRYTEARLTPIAELLLSEINQGTVDFMPNYDGAFDEPLHLPARLPMVLLNGASGIAVGMATEIPSHNLNEVTQAAIALLKKPTLETADLMQYIPAPDFAGGGQIITPaDELRRIYETGKGSVRVRARYEIE-KLARGQWRVIVTELPPNANSAKILAEIEEQTNPKPKAGkkqlnqdrlntkklmldlIDRVRDESDgEHPVRLVFEPKSSrIDTDTFINTLMAQTSLEGNVSMNLVMMgLDNRPAQKNLKTILQEWLDFRIVTVTRRLKFRLNQVEKRLHILEGRLKVFLHIDEVIKVIRESDDP---KADLMA----------------------------------VFGLTEIQAEDILEIRLRQLARLEGFKLEKELNELREEQGRLNIFLGDENEKRKLIIKEMQADMKQFGDARRTLVEEAGRAV-LTQTAADEPITLILSEKGWI--------RSRAGHNLDLSQTAFKEGDRLKQTLegpHCFTRRHPRFI--RGRTYSIDAAEIPGG--RGDGVPVSSLIELQNGAKPVAMLTG---LPEQHYLLSSSGGYGFIAKLGDMVGRVKAGKVVMTADSGETVLppvavyASSFINPDCKIIAATSQNRALAFPIGELKIMAK-GKGLQIIGLNAGES-MTHTAVSSEPEILIESEGRRGAahkdRLPVALIEA-KRGKKG---------------------------------------------------------------------------------------------------------
>UniRef50_A0Q573(11-721:742) DNA topoisomerase IV subunit A n=34 Tax=Bacteria RepID=A0Q573_FRATN   E=1e-177 s/c=0.88 id=37% cov=76%
-----------SVAEFSEQAYLNYSMYVILDRALPHISDGLKPVQRRIIYAMSEIGLSHLSKYKKSARTVGDVLGKYHPHGDSACYEAMVLMAQDFSYRYPFIDGQGNWGSIDDpKSFAAMRYTESRLSKYAVLLLDELKKGTVDWAKNFDGTMDEPKLLPAQVPNILLNGAMGIAVGMSTYIPPHNITEIINACLQLLSKPNSTIEEILEIVEAPDYPGGAnIISSKEEIADVYKSGNGSIRQQAVYEYDNHG-----NVVITKLPHQVSSAAVMEQIANELKQQKITWIKNIQDESdDKEPVKIVLySATTKNNIKKIMGHLLATTDLEKSFRVNMNMIgLDNRPQVKNLLDILNEWLEYRKHTLRRRLQTSLDKVLDRLHILEGLLIAFLNIDEVIDIIRNYDDP-------------------------------------SGELQTRFTLSEIQAEAILNIRLRKLAKIEEIEIKKEQKELQKERELLEGYLNSEVKFRNLMKKEFKQILTDFGDSRRSKIIvaEKAQALEEKDLMPSEKVTIILSKAGWI--------RCAKGENIDPAGLSYKPEDKPFLVTTGNSNIKLVFFSKLGKAYSMYVDKLPSA--RGYGEHITTYIPLDKQDQIISIAFVN---AAGYFLIASESGKAFVIPAEDLITNKITGK---NIFDADDVFKFMPFDQDHKMLAISSQGRVIIRDFASFALL-KKGKGKSIIRLDKKDKL-----------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_UPI0001976864(4-650:664) DNA gyrase/topoisomerase IV, subunit A n=1 Tax=Bacillus subtilis subsp. subtilis str. NCIB 3610 RepID=UPI0001976864  E=1e-142 s/c=0.79 id=31% cov=72%
-----------NIEQIIENNMMEYSAYILLDRALPDLRDGLKPVHRRILYSMY---LQKAFKFTKSANVAGQVM-KLHPHG--SSYGSMVGMVQKDRHIIPMLEGKGNFGqytSRD-LMPAADRYSEVKLSEISIDMMQNFDKNVVDFIDNYDGTMKMPEVLPVKFPSILAYSNSGIGVGFSSSIPSFNLKELTEAIVKYIETGEKT-------VLVPDFATGGLIVKEDNVfRQLNEEGRGTVKIRGKAEIV------KNEIHITEIPYSTTREAIIEKIVELNKAGKLKEVTDVKDLTGLKGMLITITARRNTDMNVLLEKLYKFTPLQSTFSANMNMLVDDLPKVLGVWQTIDKWLEWRTTCIKRGLSHDIETMTRKLHLLQGLEKVLLDIDEAIEIIRRSS-----------------------------------QDQIEPNLQKHFGIDFEQAKEVANMKLRNINREYIIKKIEDIDKFEKTIENYKMIVKSQDKINQIIIKGLNETKEKYGKERRTKIVEltEVKPVRLVEEVPNYAVTIYLTKEGYCYKF------------KGNQEPNLKPGDEVLKVFETENKAEILIFGSDRVCHKVELKDIDETRANALGTYLPNMI---RDKNITIVSYSILDSTHKFIIAAYSNNRIAKINLEAFQGNRTILKNsyclkqdlldMITLEDD---VSLNLLTDKSKLTVDTKN-----FNLTN----GRNATGV----------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_P11388(697-1184:1531) DNA topoisomerase 2-alpha n=47 Tax=Eukaryota RepID=TOP2A_HUMAN   E=1e-118 s/c=0.88 id=25% cov=47%
-------------------------------RSIPSMVDGLKPGQRKVLFTCFKRN---DKREVKVAQLAGSVaeMSSYH-HGEMSLMMTIINLAQNFvgSNNLNLLQPIGQFGTRlhGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFLYD-DNQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEE----------PLPMLPS-------------YKNFKGTIEELAPNQYVISGEVailNSTTIEISELPVRTWTQTYKEQVLEPMlngTEKTPPLITDYREYHTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVgclKKYDTVLDILRDFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFiLEKIDG--KIIIENKPKKELIKVLIQRGYDSDPVKAWKEaqqKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEKKDEL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D1N6B5(52-562:877) DNA topoisomerase (ATP-hydrolyzing) n=2 Tax=Bacteria RepID=D1N6B5_9BACT  E=1e-118 s/c=0.84 id=33% cov=51%
----------------MDRNFLEYASYVIKDRAIPDVDDGLKPVQRRVLWALYQV---YDGRTHKVANVVGNTM-HYHPHGNASIEDALVVLA----NKEYYITRQGNFGNIlTGSPAAAGRYIECSLSPLGHEVL--FNNDITEFVDTYDGRGVEPVTLPAKVPSLLMLGSDGIAVGMATKIMPHNFNELLEAEIAVLRGEEFELY--------PDFQQGGLMDVRE-----YNDGNGKITLRAKIEI-----VGRD-LIIREIPATTSTETLVASIEKAAEKNKIK-ISSVNDYTT-DKVEIKVVPTRGYDPEKTMQGLYMYTDCSVSISVNMTVIRENRPVQMSVSEVLRRNADKLLEYLKRELEIDLAKQEDLFH-----AKTLAQI--------------FFENRIYKKIEECKSEKEEYTEVHAGLAPFRHLLRR--------DVTDQDIDKLLALPVRRISRFDIEKNQRELAEVLAKMEEIKKNLGS---LKKYAINYLRKLLDKYGKdfPRRTEIE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A4CLF9(28-710:907) DNA topoisomerase IV subunit A n=21 Tax=Bacteria RepID=A4CLF9_9FLAO   E=1e-116 s/c=0.62 id=28% cov=58%
-----------------KDWFLDYASYVILERAVPAIEDGFKPVQRRIMHALKEMD---DGRYNKVANVVGQTM-QYHPHGDASIADAMVQIGQKD----LLIDTQGNWGNIlTGDGAAASRYIEARLSKFALEVV--FSPKITEWQLSYDGRKKEPVHLPVKFPLLLAQGAEGIAVGLSTKILPHNFIELIDASIKHLQGKRFKLY--------PDFPTAGIIDIGN-----YNDGErgGKVRVRARI-----AQQDKNTLVISEIPYGTNTSSLIDSILK-ANDKGKIKIKKIEDNTAAE-VEILVHLPSGISPDKTIDALYAFTACETSISPLGCIIEDNKPVFMGVSEMLRRSTDHTVELLQAELEILLGELQEQWH-------------------AASLERIFIENRIYRDIEEEETWEGVIAAIGKGLKPHTGHLRREVTEEDIVRLTE--------IRIKRISRFDLDKAQEHLDNLEKRIAETKHHLA---HLTDYAIDYFRELKKNFGAGR-----ERKSEIRVFDEIEATKVVIRNTKL-YVNR------------EEGFIGTSLRKDEYVTD---CSDIDDIIVFTKSGQMMITRV-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C3JAA3(47-715:899) DNA gyrase subunit A n=3 Tax=Bacteria RepID=C3JAA3_9PORP   E=1e-114 s/c=0.62 id=24% cov=69%
--------------------FLDYASYVILERAVPHIEDGLKPVQRRILYAM---QLFENGHLHKVAKIVGQTM-AFHPHGDASINDALVQLGQK----GFLIDTQGNWGnTLTGDEAAAGRYIEAKLSSLALEVL--FDSKLTEWKRTYDGTADEPVALPVRFPLLLAQGAEGIAVGLSSRIYPHNPKELLEAAIAYLRGESFELY--------PDFPTGGLLD-----VDKYNDGHrgGALKCRAKIE-----KIDDRVLSITELPFGKTTTSLIESILKANEKGKIK-IKHIDDMTAATA-DIRIQLPAGVSTDKTIDGLYAFTDCEVGLSPNACVIKEGTPVFLGVSDLLKYSADRTKELLVAQLNYRLGEVQD-------------------ALVTASLERIFIENRIYK-----DKPFEEAACEADALDHVRKRIEAMEDLVFVRPITEADLKRLLEIKMARILRFNIEKHEERIAQLMRDARTIEKHLAHS---TQYTIDYYTRLLKEFGAgwTRKTTIARFGTIEATKVIEATEKLYF--DREG------------------GFAGTGLKNAEFVA---ECSLLDEMIVIFRNGTY---RISKIEEKKFIGRGE-------------VLYINRFRRNDNRTIYNIIYRQGKrgpwlIKRCSITGIS--RDKDYNLISDEEGSRItyFSANPNGEAETVRIALKpqpRMRVLTFekSFSEVPIRGRGAKG-----------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A5E7X7(740-1238:1492) DNA topoisomerase 2 n=4 Tax=Saccharomycetaceae RepID=A5E7X7_LODEL   E=1e-108 s/c=0.79 id=28% cov=35%
------EMNEIPISDFINKELILFSMSDNV-RSIPSMLDGLKPGQRKILYGCFKRKL---KNEIKVAQLAAYVAdvSSYH-HGEQSLVQTIIAMAQNFvgSNNINLLKPNGAFGSRatGGKDAAAARYIFTELNEITRTIFNEADDPLLNYLQD-DESTVEPQWYLPVLPMILVNGADGIGTGWSTNIPSYNPLDIVANLRRLMRGEPM--EEMNPWYKG----WYGDIE---------KVGPQKFKISGRIE-----QIDDNTIEISEVPVKTWTNTVKEFlLAGLGNEKTVQWIKDMEEQHT-TSIRFVVKLSDAEMAKALSVGLLEKFKLVSTISlANMVA-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_P08096(722-1191:1485) DNA topoisomerase 2 n=1 Tax=Schizosaccharomyces pombe RepID=TOP2_SCHPO  E=1e-107 s/c=0.84 id=22% cov=51%
---------QIPIDDFINRELIQFSMADNI-RSIPSVVDGLKPGQRKVVYYCFKRNLVH---ETKVSRLAGYVASetAYH-HGEVSMEQTIVNLAQNFvgSNNINLLMPNGQFGTRseGGKNASASRYLNTALSPLARVLFNSNDDQLLNYQ-NDEGQWIEPEYYVPILPMVLVNGAEGIGTGWSTFIPNYNPKDITANLRHMLNGEPLEI-----------------------MTPWYRGFRGSITKVApdRYKISgIINQIGENKVEITELPIRFWTQDMKEYLEAGLvgTEKIRKFIVDYESHHGEGNVHFNVTLTEAGMKEALNESLEVKFKLsRTQATSNMIAFDasGRIKKYDSVEDILTEFYEVRLRTYQRRKEHMVNELEKRFDRFSNQARFIHMIIEG-ELVVSKKKKKDLIVELKEKKFQPISKPKKGHLVDLEVENALAEEEQSGDVSQDEDSDA--YNYLLSMPLWSLTYERYVELLKKKDEVMAE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q5CQG8(801-1409:1797) DNA topoisomerase 2 n=4 Tax=Apicomplexa RepID=Q5CQG8_CRYPV   E=1e-102 s/c=0.61 id=24% cov=54%
-------------------------------RSIPNLLDGLKPGQRKVLFATFKKKLNN---ELKVAQLAGYVAehSAYH-HGESSLQSTIVNMAQNFvgSNNLNLLEPCGQFGSRkeGGKDASAARYIFTKLSKWTRYIFPEADDPLLTYLYD-DGQQIEPLYYVPIIPMILVNGTDGIGTGWSSSVPNYNPKDIIMNLKRMLKGEMMvPMTPWYKSFKGKIFPikqkskknsasnGGGnnnrkktainsfnngsnssILIGSqvdaedDDLQQIQRTnnmGNGIIeetlELGANYETFGNWyKKNEETLVITELPVRRWTQDYKEWLEStllpapNADNDNIEnsWIIDYRDNSSHESVHITVRMRPEKLQQAEMEGIEKIFRLKSTLSTSNMTLFDHNSrivRYETELDILKEFIPIRLEMYEKRKNYLLSKLNYEKCLLEQKILFLKlVIQGVIGLSNKSKEtlVSDLKKNNIKSIKQVQELTQWVGVGGSNLAQNSISGSGIGGNPSFVDSGDNSMDYInfemnsfdylessqqdgilestsysretnkgnelklfdylLSMPLWSLTKEKMELLE---ADLIKKTEEYEKLLKtSIEEIWNTELDELLKVIEE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B3H4G2(673-1172:1438) DNA topoisomerase 2 n=14 Tax=Magnoliophyta RepID=B3H4G2_ARATH   E=1e-101 s/c=0.74 id=24% cov=36%
-----------------------------LQRSIPSMVDGLKPGQRKILFVAFK---KIARKEMKVAQLVGYVslLSAYH-HGEQSLASAIIGMAQDYvgSNNINLLLPNGQFGTRtsGGKDSASARYIFTKLSPVTRILFPKDDDLLLD-YLNEDGQRIEPTWYMPIIPTVLVNGAEGIGTGWSTFIPNYNPREIVANVRRLLNGES-------------MVPMDPWYRGFKGTIEktASKEGGCTYTITGLYE-----EVDETTIRITELPIRRWNDDYKNFLQSLKTDNGAPFFQDVKAYNDEKSVDFDLILSEENMLAARQEGFLKKFKLTTTIATSNMHLFDKKgviKKYVTPEQILEEFFDLRFEYYEKR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C5KAQ6(690-1197:1579) DNA topoisomerase 2 n=1 Tax=Perkinsus marinus ATCC 50983 RepID=C5KAQ6_9ALVE  E=9e-96 s/c=0.70 id=27% cov=34%
-------------------------------RSIPSMVDGFKPSQRKVLFCALKRNLKSDT---KVAQFVGYVSehSAYH-HGEQSLESCIVGMAQDFtgSNNLNLLFPSGQFGTRqqGGKDAASGRYIYTRLSKYTRTIFHPDDDDVLEYL-TEEGQSIEPKWYCPIIPMVLVNGAEGIGTGWSTNVLSYDPREIIHLLRALIRGVEL-----------------------HDIHPWYRGFTGSVERNDKNGYDFVGKvrmaSDDRTVDITELPVKTWTQNYKD-LDTLVVSVILLG-----RYHTEHSVHFKCTLQNEAAKSVVDSlGLEKAFKLRSAFSTTNMVLFdrDGKIRRYdSVLDIIKDFADLRLDMYVKR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C4PNH1(3-466:490) DNA gyrase subunit A n=8 Tax=Chlamydia trachomatis RepID=C4PNH1_CHLTZ  E=7e-95 s/c=0.76 id=34% cov=36%
-----------NLSDLFKTHFTQYASYVILERAIPHVLDGLKPVQRRLLWTLFRMD---DGKMHKVANIAGRTM-ALHPHGDAPIVEALVVLA----NKGFLIETQGNFGNpLTGDPHAAARYIEARLSPLAKEVL--FNTDLMTFHDSYDGREQEPDILAAKIPLLLLHGVDGIAVGMTTKIFPHNFCDLLEAQIAILNDQPFSLL--------PDFPPGGTMDASD-----YQDGLGSIVLRATIDI-----INDKTLLIKEICPSTTTETLIRSIENAAKRGIIK-IDSIQDFSTDLP-HIEIKLPKGIYAKDLLRPLYTHTECQVILTSRPTAIYQGKPWETTISEILR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C4R475(720-1167:1344) DNA topoisomerase 2 n=1 Tax=Pichia pastoris GS115 RepID=C4R475_PICPG   E=3e-91 s/c=0.76 id=24% cov=48%
----------IPISDFINKELILFSMADNI-RSIPSMLDGFKPSQRKILYGCYKRNLRS---EIKVSQLAGYIgeHSAYH-HGDQSLIQSIIGLAQDFvgSNNLNLLQPIGGFGSRaqGGKDASAARYIFTDLSKITKKNFS----------------------------------CQGIGTGWSTNIPPFNPVDIVANIRRLMDGQEM-----------------------EEMIPWYRGWNGSItKISAdKFRMEGNiEQIDDETIEITEIPAKTWTINMKEFLLNGIagSEKQKSWIKDMEEQHGMD-LKFVITLTKEEMKKSLQMGLKERFKLITTINVgNMVAFDaaGKIKKYDNVNEIIEDYYHVRLDFYQRRKDHLAEVLGNQLEKISSQARFVKMIIENelrvnnrkrIELIEELQRLNFPKFSKDGKPIWQQVDQEEITEAEIKVEEEEEEEIDDENLLNKSVNIFASYDYLLGMPIWSLTRERYHKLLLQKAEKEDQLTELLKL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A0BK44(356-805:1196) Chromosome undetermined scaffold_111, whole genome shotgun sequence n=1 Tax=Paramecium tetraurelia RepID=A0BK44_PARTE  E=1e-90 s/c=0.75 id=23% cov=47%
-------------------------------RSIPSSIDGLKPTQRKIIHTL----LNHSKQEYKVSSLSGLVTtyAQYH-HGEQSLQQTVVAMAQNFtgSNNINLLLPIGQFGtrSMGGKDAAQARYISTKLSSLTTKLFNEDDLHTLNYLDE-EGYTVEPFWFTPILPLVLINGAEGIGTGWSTQVPNFNPREICQQIKRKLRGEEF--EELVPWYKG---FTGSITAGTNQYIA-----KGSFI------------QHKNHLYITEIPPKKSvkeYQAFIQSKMEVAEGKSEPEILDMKEYHAGNKVCFELKVTD----EVLKQDIEKYFKLQTTIAMTNLVLFNEKgllKRYSNVSEILDEFYQTRIKFYQLRKEYLLSKYQNELELVQSKSKFIEgMIDNSIQL-----------RGLKKMEMCKKLQSLGFKGISKMEKVKSTRISKDFDADNL----EKQYDYLLSMPMWNFSEEKITAFKQQIKQLQDQITAL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B2ZYK7(19-504:514) Type IIA topoisomerase n=1 Tax=Ralstonia phage RSL1 RepID=B2ZYK7_9CAUD  E=6e-88 s/c=0.67 id=27% cov=47%
-----------------------YGTTVNLDRSVPDLYDGLKPVQRRILWSASQVCRT---QFEKSARLTGHCMGAYHPHGNSAIYSAAVNMVQHPS---PTLLGKGNFGSMT-DGAAAERYTNVRLSHYGQTFFdsDYINAETTSFVPNYDDKDVEPVTLPAQLPNVLLNGGEGIGVGITTKLPTFTPESVLEVLNRMFKGEKLQAVDFAKTLKYHHKWGGQLVRSKENQAQWKQMFVGSM---ANLQFEAvlDLDRDHKRMTISSWPPGTNLETFMKKVRAMPECHKC--------FNSKGTTTYQIECKPGFNydqFDKFVEKVRKATMQRQAFKINVTrreaKTVDGVTTFkteflaLSVPDLILQWCRMRVALELKSLAYRIKKQEAAIAYSKLLIYAVDKLDLIFKALRQSDPDASLQKLLK--------------------------------------ITAEQAKQILDLQVRKLSKLDQSKLKGTLKTQEQELKQLQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_UPI000194EBBC(37-420:424) PREDICTED: similar to putative DNA gyrase subunit A; 1114-7603, partial n=1 Tax=Taeniopygia guttata RepID=UPI000194EBBC  E=4e-84 s/c=0.82 id=33% cov=35%
--------------------FLDYASYVILERAVPNIEDGLKPVQRRILHSM---KLLDDGRFNKVANIVGNTM-QFHPHGDASIYEALVQLGQK----ELLVETQGNWGnTLTGAGAAAGRYIEARLSQFALDVVY--NPKVTEWTLS----------------------AEGIAVGLSSKILPHNFNEIIDAAISYLRGEPFTLY--------PDFFTGGSIDVSR-----YNDGErgGVVKIRAKIE-----KIDNKTLAITEIPYGKTTATLIESIVKAQEAGKIK-IRSVVDNTAQTANVIVYLL-PGTSSDKTIDALYAFTDCEVSVSPNCCVISDNKPHFIGVSDVLRHNVDRTRDILGQELRIQLGEVREQLH-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A2I985(1-262:262) DNA gyrase subunit A (Fragment) n=5 Tax=Campylobacterales RepID=A2I985_9PROT  E=4e-76 s/c=1.10 id=42% cov=30%
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EDLIPNEPMVVTITHNGYVKRVPIKSYERQKRGGKGKVAVTTHDDDFIERFFVSNTHDTLMFVTNMGQLYWLKVYKIPEGSRTAKGKAVVNLINLRADEKIMAIIPTPDFDESKSLVFFTRNGVIKRTSLNEFSNIRSNGVRAIVLDDADEIVTAKIADvQTQYIMIFTSLGQCIRFELEKTRDQGRSTRGVRGIKFKiDTDIVVDADVIDNEEqEILTVSEKGIGKRTTIEEYRLTNRAGSGVIAMKLSPKTGNIVGEVLV--------------------------------------------------------------------------------------
>UniRef50_C8XUB8(9-445:446) Gp52 topoisomerase II medium subunit n=1 Tax=Shigella phage phiSboM-AG3 RepID=C8XUB8_9CAUD  E=2e-63 s/c=0.56 id=24% cov=44%
-------------------------------RQIPQLIDSLKPSQRKILFAALEYNkeeIVDRLGMFAAART------NYKSGGEN-MSGTIVNMAQGFpgTNNIPYFDRDGQFGSIMGRDASSARYISVAVSDVIRKIFRKEDEGILEY--NYLGEERlEPKFFLPILPMFLVNGINGIGTGYSTDTPCHCVKSVLSALRALLRGED--PKDLKPYWNGYKGETG-------------YTEEGRAYSRGIFR-----RVNATTLHITEVPVGWFAKTYETKV--LLPLYKAGILTEYANDTTEDGWDITVVFKRGELSKLSDEQVEQMFKL---YSANKPVWtawdEDGVIhRYAGWQDMLLPFFNYRLSRYEDRRQYLLKDMADR--------------------IRKLGDRAVFIE--------WATRVDLRQKIDVLKSLFMQDYPDFGGDL----------DELFKMPLSSITLDARERLLKQIENLEAQHKEL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C0QRN3(2-1216:1217) DNA gyrase subunit A n=9 Tax=cellular organisms RepID=C0QRN3_PERMH   E=6e-59 s/c=0.19 id=27% cov=91%
-----SEIIKQPIEEEVKSAYLDYAMSVIVGRAIPDVRDGLKPVQRRILYAMNELGLYPNKPYKKSARVVGEVLGKYHPHGDTSVYDALVRMAQDFTLRYPLIQGQGNFGSIDGDPPAAMRYcvtgdtlintdrglikikdivpdseensdnpINIKVQSLNRkinhsDMFFNSGKHKTIKLETEEGYEIEGSFNHPVLTWTTENGK--PVYKWKT-------LDSIRAGDYLVVSRENDIDSDQDLITEEEAVLLGSLVSEGYISENRAGFNNTDEEYASVfenaykdiygdtfcRYERTLKSGKTLVE-----YQIHHKEIIQDIREKEFDKK----------SSDKEIPFVVLQSSKRVQRAFLKALFEgdgtvyetaravnisysskskkllkqlqvlllNFGIVSRIhrdkqnyrliisGYQNIKLFKEKvgflgKKQEKLIKLVEkiykketansktDFIPFIADYIRDKYrgkgfnEWLSKHSLDRYHKIEKYWDTLSNIlDEedrsllkellynryyfakvktveetgekiVYSIRVKSdchsfvgngivnhntearltklamemladidKNTVDMKENFDASLMEPEVLPAKFPNLICNGASGIAVGLSTNIPPHNFSEVAEALKYLAEFPnatveelcqfikgpdfptggilitpfeeivkiytdgrgsvtvkgkarIERLPGNRHRIIIYEIPYQVNKVELIKRIaelvrkgqekgisdLRDESDRDGIrIVVELKReadpekvLKKLY---RRTQLQKSIP-INLTVLVGKQPKTVDL--KGLLqefikhrvdvitRRTLFDLEKAENRLHIVEGLLKALENaDRVIDIVRSSkdvssarsqlveefelsdTQAQAILDMRLSRFTALEGDKLyqeaddlrlkieeyqrilssEEEKIRVFIEEIDELLEKFGDERKTVIVEEKEAGltfEEHYILAVLSSGRIlnrridddadkkdifqkvmnevvssvkpgeKLISVQEVESsipiafITDKGKAYwslvadlpkgegrINIDEGEIVGTAFKGEGEEDrLFILTKNGIikrmsyedifyksqnhsiiplaeddcvvtafaddhpsligvytrkgdLLLFERNQVRVTGDKAKGVEAIDLDEGDTVAGGFLINSEDLIMTVTKNGYTKLVRKEEFftkegKVKKRAQKGLMAVKLG-KDDFLSVAVPVELDETVYFSTEKGRVLKLIVDQkrIPVAKRTAMGDPVLKI-EGDYVV-----------------------------------------
>UniRef50_D0HVU0(1-371:381) Topoisomerase IV subunit A n=3 Tax=Vibrio RepID=D0HVU0_VIBCH   E=2e-52 s/c=0.57 id=26% cov=34%
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QGLLIAYLNLDEVIEIIRNEDDP---KAVLMAR----------------------------------FDLTDIQADAILDTKLRHLAKLEEMKIRGEQDELEKERKKLEELLGSERRLNNLLKKEIKADADKFGDDRRSPLVerEEAKALTERDLMPSEAITVVLSEKGWIRHAKGHDVDCQ--------SLNYKAGDNYLTHACGKSNQQAVFLGSDGRSYSLESHTLPSA--RGQGEPITGRLNVAEGTTIRQVVMG---EEDQLWLVGSDAGYGFVCKGDDLLSKNRSGKALINLPENSEVMTPQVIAdlDNDEILAITNQGRMLLFPIKDLPQLSK-GKGNKIIN------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q00GN5(51-247:292) Plastid DNA gyrase subunit A protein (Fragment) n=1 Tax=Karenia brevis RepID=Q00GN5_KARBR  E=3e-24 s/c=0.59 id=27% cov=20%
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KRLRASELKEQLKNKKpsGKPCFGMMPGDSLMNLYCCHDDDKLLAFSEDGRVLMMNALAVPPPRLISaQGSALSELLPaLGEGHKVTALVVMPDFNfddyEDEFLVLVTGCGIAKKVLIKELGRLRPgKSLQCMRLDEGDELRWAHRARGNFALVCATEKGHVLRCSLGpQWRCSSLKVGGVAALRLR----------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_UPI00017582CB(1316-1560:2150) PREDICTED: similar to paraflagellar rod protein, putative n=2 Tax=Coelomata RepID=UPI00017582CB  E=1e-13 s/c=0.33 id=19% cov=27%
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VEKESLLENLSQL-EERHQEEIKVFDDQSKKDT--IEIKNRIEENEKICIEYRKVISKLEEDLDLNLRELNDAKQKNYSLQEALEHSKETERQIADKTSEEILKLVQENAQLVemnRKLQTTRDNCKQVecqTEDSTNSELEEVVSGLKRENSELLAEMNEMNQALKERGETISKLQSHCEEVMKKLQLYETQANKNVD---------NISQKEEIIKKLEDEIERLKatSDLNSNTSEISDLKNEIENLKER---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C6A0L9(472-664:895) DNA double-strand break repair rad50 ATPase n=1 Tax=Thermococcus sibiricus MM 739 RepID=C6A0L9_THESM  E=2e-09 s/c=0.35 id=16% cov=22%
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IEKKKEEIAEALRKALKRKTELEK--------IRNNESKLIKLHKTL-EFLENVESKLEKYNIEELKKKTEEFEKVR--ERVIEVKKEIIRVNKELEKLNEFKNE-KETLLRKLGDLERKKAEVLHEIEEKGFESFEDVEKRLKELEPLYKEYI------SLSNvpQEIQIREKRQELLETTLKDKEKDLNLTKNVFKMLSKEIEELKVRF--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_P41513(1-856:878) DNA gyrase subunit A n=98 Tax=Bacteria RepID=GYRA_ERWCA   E=0 s/c=1.28 id=87% cov=97%
MSDLAREITPVNIEEELKSSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMSVLGNDWNKPYKKSARVVGDVIGKYHPHGDSAVYETIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRMSKIAHELLADLEKETVDFVPNYDGTEQIPDVMPTRIPNLLVNGSSGIAVGMATNIPPHNLTEVVNGCLAYIDDENISLEGLMEHIKGPDFPTAAIINGRRGIEEAYRTGRGKIYIRARAEVEADAKTGRETIIVHEIPYQVNKARLIEKIAELVKDKRIEGISALRDESDKDGMRIVIEIKRDAVGEVVLNNLYSQTQLQTSFGINMVALHQGQPKIMPLKDILVAFVRHRREVVTRRTIFELRKARDRAHILEGLAIALANIDPIIELIRRAASPAEAKASLIAQAWELGSVATMLERAGDDAARPEWLEPEFGIRDGRYYLTEQQAQAILDLRLQKLTGMEHEKLLDEYKELLAEIAELLYILNSPERLMEVIREELEAFKTQYSDERRTEITANTADINIEDLINQEDVVVTLSHQGYVKYQPLSDYEAQRRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPEASRGARGRPIVNLLPLEADERITAILPVREYEEGRHIFMATASGTVKKTALTEFSR-HVSGIIAVNLNEGDELIGVDLTDGSDEAMLFSAEGKVVRFSEQAVRSMGRTATGVRGINLQGEDRVVSLIIPRGEGDILTVTQNGFGKRTAVSEYPTKSRATKGVISIKVSERNGKVVGAVQVDAADQIMMITDAGTLVRTRVSEVSIVGRNTQGVTLIRTAEDEHVVGLQRVAEPVEDEELDGV------------------------
>UniRef50_Q5HJZ0(1-844:887) DNA gyrase subunit A n=200 Tax=Bacteria RepID=GYRA_STAAC   E=0 s/c=1.21 id=52% cov=96%
MAELPQsRINERNITSEMRESFLDYAMSVIVARALPDVRDGLKPVHRRILYGLNEQGMTPDKSYKKSARIVGDVMGKYHPHGDSSIYEAMVRMAQDFSYRYPLVDGQGNFGSMDGDGAAAMRYTEARMTKITLELLRDINKDTIDFIDNYDGNEREPSVLPARFPNLLANGASGIAVGMATNIPPHNLTELINGVLSLSKNPDISIAELMEDIEGPDFPTAGLILGKSGIRRAYETGRGSIQMRSRAVIE-ERGGGRQRIVVTEIPFQVNKARMIEKIAELVRDKKIDGITDLRDETSlRTGVRVVIDVRKDANASVILNNLYKQTPLQTSFGVNMIALVNGRPKLINLKEALVHYLEHQKTVVRRRTQYNLRKAKDRAHILEGLRIALDHIDEIISTIRESDTDKVAMESLQQR----------------------------------FKLSEKQAQAILDMRLRRLTGLERDKIEAEYNELLNYISELEAILADEEVLLQLVRDELTEIRDRFGDDRRTEIQlGGFENLEDEDLIPEEQIVITLSHNNYIKRLPVSTYRAQNRGGRGVQGMNTLEEDFVSQLVTLSTHDHVLFFTNKGRVYKLKGYEVPELSRQSKGIPVVNAIELENDEVISTMIAVKDLEsEDNFLVFATKRGVVKRSALSNFSRINRNGKIAISFREDDELIAVRLTSGQEDILIGTSHASLIRFPESTLRPLGRTATGVKGITLREGDEVVGLDVAHANsvDEVLVVTENGYGKRTPVNDYRLSNRGGKGIKTATITERNGNVVCITTVTGEEDLMIVTNAGVIIRLDVADISQNGRAAQGVRLIRLGDDQFVSTVAKVKEDAEDETNEDEQSTSTVSEDgtEQQREAVVNDE----
>UniRef50_D0LNR4(1-859:891) DNA gyrase, A subunit n=3 Tax=Bacteria RepID=D0LNR4_HALO1   E=0 s/c=1.18 id=52% cov=98%
MSDIA-NVTPVAIEKEMRSSFMDYAMSVIISRALPDARDGLKPVHRRILFAQKGLSNYWNRPYLKCARIVGDVIGKYHPHGDSSVYDALVRMAQDFSMRYELVDGQGNFGSIDGDPPAAMRYTECRMARLASDLLADLDKETVDWQPNYDDKELEPTVLPTKVPNLLLNGASGIAVGMATNIPPHNLGEILDATMALMEDPDLPEEELAEIVPGPDFPTGGIIHGRGGIRAAHTLGRGAVVIRGRTQFETVRK-ERKAIVVTEMPFMVNKSRWIETTAHLVRDKRIDGISDIRDESDRKGIRVVFELKRDANEQVVLNNLFKMTALQTSFNVNMLAIVDGRPQVLSLRSALQVFIEHRRTVVRRRCLFELRQARERREIVEGLGLAVMQIDRVIEIIRTSKDTDEAKARLMSERMMGLDGF-------LERAGRPADEVEAVRTAGFVHLSARQAQAILDMRLGRLTGLEREKVEAEYRELWEITDYLEGILGDDVKLRGVIVDELREMRDQYADPRRTEIVDQEGEILDEQLIKVEDMVVTRTRRGYVKRTALDEYSAQGRGGKGVRGAASGDDDFVADMFVASTHDHLLMFTNIGRVYQKKVYELPSGSRISKGRPFVNVIEaLQPDEYVVGMLPVKEFTDDLSAFMATRMGTVKKTVAAAFSRIRVTGIKAIGIDDGDELVEVRLTRPDMDVLLVTKRGQSIRFQEDQVRPMGREARGVRGIGLAGGDAVVGMSVFERDceDAILTVCENGYGKRTLLSAYSTQGRGGKGLITIKTTERNGPVSGVRLVGEDDHVIMISSTGKLIRMRVRDIPVQSRATQGVRLMRLDPGEQVASLERLAEPDDDADSEAVTPELGD-DDEIGNEV---------
>UniRef50_B0MRF5(9-852:878) Putative uncharacterized protein n=2 Tax=Clostridiales RepID=B0MRF5_9FIRM  E=0 s/c=1.18 id=44% cov=96%
----TEKLIQVDIEKEMRESFLQYSMAVLVSRALPDVRDGMKPVHRRIIYTMNEADNTSSKPYRKCAYTVGEVLGKYHPHGDASVYDALVRLAQDFSMRYPLIDGHGNFGSVDGDPPAAYRYTEARMAKIASELLKDIKKDTIDWGKNYDDKLDEPTVLPVKFPNLLVNGSVGIAVGMATNIPPHNLNEVCDAIVARMDNPECSIEEILQYIKGPDFPTGGIIMGYSGIRSAYYTGRGKITLRGKAEIVEEGNHSR--IIVTEIPYMVNKSKLLETTGQLMRDKRIEGISNLRDESDKDGMRIVYELKRDVNAQVVLNKLYSFTQLQDTVGVIMIALVNGEPKQLTLLEILDNYIAFQKQIITRRTAFDLKKARERAHILQGFLLAIDNIDEVISILRSSKSVQEGKERLMERFKEDDLAKLLQRAMG--------ENYKDVHFEHEIGLSEEQADAIVQMRLGQLTGLERDKVISELAEIMEKINDFLDILSSDERVKEIIKEEITAIKEKYGDERRTAIEPVSGEVDIEDLIPEEECVLTYTNIGYIKRQPVDVYNLQKRGGKGVSGMKQREEDFVEDMFISSTHDNILFITNYGNMYKLKCYEVPEGSKQSRGTNIVNLLQLDEGERIAAMMKTSDFAENKYFICVTKYGKIKRTPLYDFRNVRKNGLRAITLAEGDEIAAAHLTEGDSSIIVATHLGMAIHFSEDKIRSMGRLAAGVRAIKLREDDYIVGAAkVYSDDMRILTVTDKGYGRLSALSDYRMQNRGGNGLKNYKIRDDRGYVCGIRSIQADDDVILISTDGVIIRIRANDLRVMRRTGLGVRVMKLSDEDRVVTFTR-TEHDETADIEEVE-----------------------
>UniRef50_Q89AS3(1-838:847) DNA gyrase subunit A n=11 Tax=Proteobacteria RepID=GYRA_BUCBP   E=0 s/c=1.18 id=63% cov=96%
MKEVAKEIIKIDIEDELKNSYLDYAMSVIIGRALPDVRDGLKPVHRRILFAMKVLNNDWNKTYKKSARIVGDVIGKYHPHGDTAVYDAIVRMAQPFSLRYVLIDGQGNFGSIDGDSAAAMRYTEIRMSKIAYELLNDLDKNTVSFFSNYDGTEKIPEVLPAKIPNLLINGSSGIAVGMATNIPPHNIKEVINGCLAFIDDQNITLKKLMEHIPGPDFPTAGLINGKRGIEKAYKTGKGKIYIRAKSIIEIQKKTKKKSIIIYELPYQVNKARVIKGIANLVKEKKIEGITTLRDESDKEGMRIVIEIKKETKAEIILNQLYSLTQLEISFGINMVALIHGQPKVMTLKEILNAFINHRRKIIMRRSLFELNKIRKKIHILEGLIISLDNIDLIINLIKKSSTLEEAKNKLKTYHWYSKHAQYTQILKKNAHSLTPYDKKLRPIDTQKFFLTPEQIQAILELRLQKLTHLEHKKLISEYKQLFKTSNNLENILKNNNILTKIMKDELIKIRDNFGDKRRTKINVNYSDINTSDLINKENVVITLSYSGYVKYQLLSSYEAQKRGGKGKLAVKTKEEDFIENLLVANTHDIILCFSSKGILYWMKVYQLPEASRHARGRPIVNLLPLSSNERITAILPISEYKDSINIFMATSKGMVKKTSLYEFKKPRTKGIIAINLKADDELIGVSLTNGNNTIMLFTAQGKAVHFSEILVRKTGRTAIGVQGIKIKKSDKVVSLVVPKKHGNILLITEHGYGKRTEIHEFPIKSRATQGTIAMKITKKNGIVIGTMQVVNQDQIIIITNAGTLVRTRVLEIGILGRNTQGVIIIRTSKKEKVVALQK-------------------------------------
>UniRef50_C6XJ15(40-967:981) DNA gyrase, A subunit n=28 Tax=Bacteria RepID=C6XJ15_HIRBI   E=0 s/c=1.04 id=52% cov=98%
-------VSPINISDEMKKSYLDYAMSVIVSRALPDVRDGLKPVHRRILFSMSEQGYTFDKAYKKSARVVGDVIGKYHPHGDQSVYDALVRMAQNFSMGLPLLDGQGNFGSMDGDPAAAMRYTEVKLKKVANHLLADIDKDTVNFQENYDGSEKEPIVLPARFPNLLVNGGGGIAVGMATNIPPHNLGEVIDATIAMIEDPNIDDEALLEIVPGPDFPTGALIIGRAGSRSGLMTGRGSVIMRSKSSIE-ELKNGREALVFTEIPYQVNKASMIEKIAELVRDKRIEGIADMRDESDRDGVRVVVEVKRDASPEVVLNQLFRYTQLQTSFGMNMLALNSGRPELLSLKAILQAFIIFREEVVARRTKFELNKARARAHLLVGLALAVANIDEVIKIIRHSPDPSTAREKLMDRAWPAQDMLSLINLIADRRTVANEVGE--------IRLSEEQARAILDLRLQRLTGLGRDEIGDEARGLADRIADYLDILSSRPRVMEIITEELRVVREEFAIPRRSQFIEAELDMDDEAFIEKEDMVVMFTHGGYAKRTALSIYRTQHRGGRGRSGMGTKEEDAVTRFFVANTHTEVLFFSSTGMVYKTKVWRMPLGTPQSRGKALVNLLPLDKGETITSVMPLPEDEEERanmNILFATRSGGVRRNKLSDFTQVNRNGKIAMKLDEaqvagsDDGIVGVQICSPDDDVMLTTALGQCIRFKVEDVRVfTGRTSTGVRGIRLANGDEVISMLVLRhmditspearaylkhasamrralgeeegdteidvvsepdaddegdeaalsperiaelgaAEEFLLTITEDGMGKRASAYDYRVTGRGGKGLIAHKLNAGR-RLAAAFPIEDGDEIMLVTDAGQLIRTPAKQIRIAGRATQGVKVLRTSGEERVVSVERLAEQESDVD-ENETEENVDGSAEIV-DVAIDGAPEGE
>UniRef50_Q2GCH4(2-864:869) DNA gyrase, A subunit n=2 Tax=Neorickettsia RepID=Q2GCH4_NEOSM   E=0 s/c=1.08 id=47% cov=95%
-------IIPVNLEQELKSSYLSYAMSVIINRAIPDVRDGLKPVHRRILYSMNELSFYWNKPYRKSARVIGEVIGKYHPHGDSAIYDALVRMAQNFSLLVPLIDGQGNFGSIDGDPAAAMRYTEVRLEYISKFLLDDLYENSVDFRSNYDNSETEPVVLPAKFPNILVNGTAGVAVGMATNVPTHNLSEVIEACKLYLENNNVTTDELLKVIKGPDFPTGGLIIGEEGIKASFESGRGSIIIRSKTHFEETEAG--KAIIVDELPYQVNKAKLIENIALLVKEKRLDSISDLRDESNKEGIRVVIELKRGASFEVVLNQLFQMTQLQTSYSTNMVLLDNMRPTLMSLRDILAAFIAHRKEVISRRTEFRLAKAREKANVLVALYVAILNIDEVVHILKSSGDNEAAIKALSAKHW----------AIDEELELLVETISNIKLLNREYKLSTAQSKAILEMKMQRITNTEKGQLVAEIHAEMDIVKECASILGSEAVLTNVIVRELNEIKAKYPQARKSIILKNVNAVyAEEDLIEREQVVVTATYSGYIKRVHISNYRVQRRGGKGRIAQNIKSEDQLAQIFVLSTHDEILFFSSRGKVYKLKAYKLPIGEPQSRGRALVNIFDLADDESITSILPLKS-SDAENLIFLTAQGKVKRNSMSDFAYVPANGKVAIRLNDNDALISVKTAQNEDCVFISTRDGKCIRFLVGDLRVLkSRSSEGVKAITLGKDDNAISLSILNkqvlspedkaeymktkfferiqnpenhEEQFVLTVTENGYGKITSSYEYRITNRGGVGIINISTSERNGKVVSSFKVTLSNHIMLVTNRGQVIRIEANNIPVLGRNTQGVRLFSIRAEERVASVTEV-EEVEDDDSETTE-----------------------
>UniRef50_O33926(1-804:804) DNA gyrase subunit A n=8 Tax=Thermotogaceae RepID=GYRA_THEMA   E=0 s/c=1.14 id=45% cov=91%
---MPEILINKPVEDELVESYLLYSMSVIVGRAIPDVRDGLKPVQRRILYGMYELGLKHNSPTKKSARIVGEVMGKYHPHGDAPVYDALVRMAQPFTMRYPLIEGQGNFGSIDRDPPAAMRYTEARLTRLAEEMLEDIEKNTVNMIDNFDGTLKEPEVLPSKVPNLIINGASGIAVGMATNIPPHNLSETVDALIYLIDHPEATVEELMQFIKGPDFPTGAVVVNASELKKVYEEGRGRIIVRGKVHVEDGKRV--KRIVITEIPYGVSKAGLIEQIAKIAKDDESLPIRNIRDESDKRGMRIVIEIPKDANEEVIINNLYKRTALQDYFNVQMLVIDkHKRPRLMNLKGLMEAFLEHRFEVIRRRARYEYEQYTRRAHVVEGLLKAARAIGVVVDIVRNSKDVESARQSLME----------------------------------TLEITEEQAKAILDMRLSRLTSLEIENLQNEYSDLVRKISEVKEILEKDEKVKEIMKKEFLYLKQQYGDPRRTEVTDQSIEYNEEELIVEEDVVITLSHKGYLKSTPLNSYRSQKRGGKGITVSKLSEDDEVEFVVVAKNTSSTLFITNLGRAYVLKNYQLETTGRNTRGRHITAFLNLEDTEKIVALASLNG--EGRDLVIATKSGKIKRTALKEFENaTSNRGVRAIKIEPGDEIVSARVVNSEKEtLIVATKMGMAIRFPVSDVRRMGRNAAGVQAIKLQPGDEVVSVDVIPPgeEGEILTVTEKGFGKRTPVQLYRIQRRGGTGLRNISDVNKTGYVVAVRYVRGDEEIVVVTRNGMMIRFPVSEIGVIGRVTKGVKLIELGD-DTISKVAVVKD----------------------------------
>UniRef50_Q9HJB6(4-796:796) DNA gyrase, subunit A (GyrA) related protein n=5 Tax=Thermoplasmatales RepID=Q9HJB6_THEAC  E=0 s/c=1.12 id=43% cov=90%
-----------AVEVEIRKSYLEYAMSVIVSRAIPDVRDGLKPVQRRVLYSMRELGVTHDKPYKKCARIVGETMGKYHPHGDMAIYDALVRMAQDFSLRYPLVDGQGNFGSIDGDSPAAMRYTEARLTQIAEDMMDDIDENTVPFRLNFDGTLSEPEYLPSKIPNLLINGSSGIAVGMATNMVPHNLTEICDAILYEVDHRDSPVDDLLKYVKGPDFPGGGIVFYGKDLIEAYRTGRGKVIVQGEVD-----ATEDRRLIIKSIPYGVNKADLVQSIADLAKNEVIKDITDIKDESDRNGIRIVIKVRDDDIKPLVLNQLYEHTALESSIGIINLVLVGNQPKLMNLKDLIDSFIDHRLDVILRRSQFRLDRKKERLDVLTGILTAVEHIDRVVEILKSSKDADEASSKLR----------------------------------NEFDLNDRQIKAILEMRLQRLVNTEQESVRSEIAQIQAEIKDLEEIILSEDRRIDEFKKEITEIQKKYGDKRRSRIKfRGITERTMEDLIPNEESLIMLSYGGLVKRVQADEYRSQRRGGKGVN-TSMKTSDSIKSMIHCFSHDTVYYFTNTGRVFKSKAYEIPKKSRTSLGVSAAAFLKLAQGERVTEIMKAPP-EKGYYLILVTRDGSVKKTAADPVFDSKSSGLKIITLEDDDELVSVSYTAGDKNMFVLSSKGKASVFNTSEIRETGRTSMGVRSMRLNEGDTILTAFVVNSDEDILSISEKGYGKRTNISEFPIHHRGSSGVMVYRDTERTGRVSHAIPVRDEDEVILVSMNEKTIRIKASEIPETSRVTSGVKLMDIDGDDRVIAAAVIK-----------------------------------
>UniRef50_Q4A7J5(39-853:853) DNA gyrase subunit A n=5 Tax=Mycoplasma hyopneumoniae RepID=Q4A7J5_MYCH7  E=0 s/c=1.09 id=42% cov=93%
LESITDNISPIKIEDEMKASFLDYSMSVIVSRALPDVRDGLKPVHRRILYTMAELGITSGTSYKKSARIVGDVLGKYHPHGDASVYESMVRMAQPFSLRYPLVDGHGNFGSIDGDEAAAMRYTEARLSKISNKMIEGLKKNTVDFRPNYDASEVEPEVLPAKFPNLLVSGVSGIAVGMMTKIPPHNLGEIIHSFIIFAKNPKIEINELISSLPGPDFPTGATIYGKKGINQAYLTGKGSFIIRAKAKIE-NLNSGRSRIIFYEIPYEVKKPAIIEKVAFLVRNKKILGIKDVRDESSRHGIRVVFEIKKGFSPEIILNKLYHSTDLQINYSINMLALVNGVPKLMNLAQIFNYYLEHQKEINLRSLNFDLEKATEKLNVLEGIKVAVENIDEVIKIIKSSKSDQAAQEKL----------------------------------AHTYNLNPGQTKAIIEMRLGRLTSLAIEKLNNEIEELKVEISEIKSIIDSPKKLIDLIIEQHKNVVAQFGDPRRSEIIPEIDCLDEEDLIADEQVIISLTQNNYVKKMALDEYRLQNRGGIGTLASNHYKDDELKSLCITNTLSDLLIISSSAKIFKLRAHQIPDGSKQGKGIPILNLIKLEKNESISNLIPWNQEYDNHWLITVSAFGNIKKTALSAFRNITKNGKIALKLAENDYLVSAFIApnNPDLNILIGSSQGFVNRWSIKLLRDSGRTAIGVKGIKLEEGHKIIGACFAFDNNFIFSLSKKGFGKKTQVGEYRLTGRTTKGLMSLD-AKKAGNLVFISAIKNNQEAIITTKKGFAIRIDLDMVPIISRKTKGVKIITLKKGDEITAVSLISKNETEKQNE--------------------------
>UniRef50_Q2JY71(23-835:849) Type II DNA topoisomerase, A subunit n=10 Tax=Cyanobacteria RepID=Q2JY71_SYNJA  E=0 s/c=1.06 id=41% cov=89%
-------VIVTDLQGEMQRSYLEYAMSVIVGRALPDVRDGLKPVHRRILYAMHELGLTPDRPYRKCARVVGDVLGKYHPHGDQAVYDALVRMAQDFSSRYPLVAGHGNFGSVDDDPPAAMRYTECRLAELSHTaLLQGISEAIVDFMPNFDGSQAEPTVLPARLPILLLNGSAGIAVGMATNIPPHNLGEVVDGLLALIDEPDLSPEELLRWIPGPDFPTGGQIVDGQGIREAYLTGRGSITLRGVARFEEIqpgrGRHRRPALIISEFPYQVNKAAWLEKVAELVAQDRLSGIADLRDESDRSGMRVVVELKREANPQAVLQQLYKLTPLQSTFGVILLALVEGKPQQLSLKQILQHFLQFREATLKRMFRAELQQVQRKAEEVAGMVLALADLEGVIDLLRQAPDSATAKAQLQTR----------------------------------LGCTSQQAETILAMPLRRLTTLERERLYQEQAELQARIAELQGLLQDRRKLLNYLKKELRHLKKTFADPRRTQILSASELEAEAAQIPggeageDSRFLLQLTRKGYVRRLPLPGPRS-----RSNPAQRELGEDTLVSLECVTPEQAILVLTASGRAFTVPIEGIPLSTGSSRGVPLVTLLP--NPEPIVAAFPLDPVrvsgaehsPGEASLVVLSRQGRIKRVALAELVGLSQRGAAVLKLKEGDELGWAALWHPGHQgysVVLATSGGRVLRLDAEQIPLMGRAAMGSPALRLGRTEQIVGMALLPPQGILVLASRSGYLKRLPLGEIPILEQGKVGVSAFHFSNKGDGLVGLVgfppdlAAHPHLQVDVIAESERVHSFSPEEIPLQGRSGGGSLLVK-------------------------------------------------
>UniRef50_B3TAI1(1-898:898) Putative DNA gyrase/topoisomerase IV, subunit A n=1 Tax=uncultured marine microorganism HF4000_APKG8D23 RepID=B3TAI1_9ZZZZ  E=0 s/c=0.96 id=41% cov=94%
---MAENLLRRDISDEMEESYINYAMSVIIGRALPDVRDGLKPVHRRILWGMHQAGHTHDKGYSKSARSVGEVMGKYHPHGDQALYDTMVRMAQDFSLRYPLIDGQGNFGSIDGDPPAAMRYTESRLDRLSQHMLDDINKDTIDMEPNFDDTETEPTVLPARLPNLLLNGSDGIAVGMATKIPPHNLNEVAAAIKFHVEKvveqnrkigldnpPKIDASEYMEYLKGPDFPTGATIHGVDGILDMYRTGNGRFQIRSDVEVQEDSRG--KRLVVHSIPYQVKKAGMLQGIAELVRKDIIKGIRDIRDESSKEGIRVVIEIKQNADPHAVLNQLYQSSRLQESYSANMMGILNGEPVQLDLRTILHTYVRHRESVVERRTQFEFDKAEARAHILHGLLRAQKRMGEIIEVGRSSDSRDQFEQYLR--------------------------GDEKYPKIRRFDFSDKQAKAIAERRLYQLTKLNVQEVADELKKLKGAIKDYQNILGSRIRRLNIIISELDEVVDRHGDERRSRIDPMPLSMDREDLVAEQAIVISLTRDNYIRHLPVESFRLQNRGGKGLKGVVTKEEDAPSKIVTCFSKDRLLIFTDMGRVYGLRAWETPSASRYGRGSHIRNLLTrIRDDEKVISILPMSrsliENPEGHYLMFATANGRIKKSRLSEYVKINRNGKYALRFAGGeeDALVSVRPATDADHVVLVSSHGNACRFMPAQkksrvdsnsgetitthvVRVQGRVSQGVSGMKLRKGDQVIGMIVTDDfDTSVLTISRYGMAKRSRLGSgemkpvldddsmpvldedgglvqqrdgYRRTNRGTRGVRTMSLRDG-DHIVSVRQVPDlDDQLFMLTGTGMMIRMVSGQTKETlGKVTKGTRIMelrnadRTGYVDEIIFVARLPADLVDSSDAEGPSLEEE------------------
>UniRef50_C0ZEN0(2-835:847) DNA topoisomerase IV subunit A n=1 Tax=Brevibacillus brevis NBRC 100599 RepID=C0ZEN0_BREBN  E=0 s/c=1.01 id=38% cov=94%
---LSNQIINQSFAEIMGKRFGDYANLVILSRAIPDARDGLKPVQRRILYAMYQEGNTNDKPYRKSAKTVGYVMGTYHPHGDSAIYETMVRMAQWWKMRQVLIQGHGNFGSLDADPPAAMRYTESRLSALANELLRDIEKDTVTFIPNYDNSAQQPAVLPSRFPNLLVNGAAGIAVGFATDIPTHNLGEVIDAAVAQMKNPNISLDELMQHVKGPDFPTGGIVQGLSGIRKAFETGRGQFIIRGKTHVEEPKGGKIKKIVVSEIPYEVVKSKLVGQIDELVMERKIEGALAVRDETGRkeaeqKKVRIVVDIRKEADEQAILNYLYKNTDLQIYYNYNMNVIHEGTIRQMGLKALLGAYIDHQKEVVTNRCQYDLDRKQSREHIVEGLIRAKSILRQIVDTIMDSEDRADAKKNIMEK----------------------------------YGFTDNQADAILSIQLASLTRLDIVKLEKELATLAKEIEELKSILASEKKLIQVITGELNEIKKKYAEERLTEIQGEIEEIKIDIAmqINAEDCIVTLTNEGYIKRTSPRSFKS---VGGTLETCGVKEGDRVRYFMETNTSHTALFFTQDGKYFATLVNAFPDDKWKDIGSALVNIIPLEKNQRIVGFTIVENFKQPLYVYHVSKNGLMKKTALSEYETNRSSALVAAKLKGGdDEFMNVFVADEAGAILGATKDGMGIRFQRSEVSATGRASSGVKAIALAPGDDVITMLPIEevDSRAFSLLTAEGVVKRTAIGAIPLQARAGKGVQLIRKRKNNPHELVAMFLEET--VYAWTSQNEWTLVETEQVIVNEQGGIGRQLI--EGGVKAVAFETILPTDEPKDEATAkgsgDGSGTAGQQKTSN-----------
>UniRef50_C7XU56(1-829:843) DNA gyrase, A subunit n=16 Tax=Lactobacillales RepID=C7XU56_9LACO   E=0 s/c=1.00 id=37% cov=93%
MSD--NKIEELTLEQLMGERFGRYSKSIIQERALPDIRDGLKPVQRRILFAMNKDGNTYDKGFRKSAKSVGNVMGNFHPHGDSSIYEALVRLSQDWKLREPLIEMHGNNGSMDGDPAAAMRYTEARLSKIAGLMLRDIDKDTVEMTLNFDDTEKEPTVLPARIPNLFVNGATGISAGYATEIPPHNLRELIQALIYLLKHPEAFLDDLMTYVPGPDFPTGGIIQGVDGIRKAYETGRGRVILRANTTIE-ELRGGRQQIIVTEIPYGVNKAQLVKRINDLRLNKKVEGISEARDETDRSGLRIAIELKRNADANGILNYLLKNTDLQINYNFNMVAIDNQRPMRVGLKHYLKSYLAFQQEIITRRTQFNLHKAQTRLHIVEGLIKALSILDQVIKTIRASKNRKDATQNLV----------------------------------NEYQFTQPQAEAIVALQLYRLTNTDVTDLRDEQQRLNDSIAEYNKILNDQNELNRVLVKEFKAIDKQFGSDRKTQIEKHIQKltVDTKVTVPDEEVVVLVSHAGYIKRTSLRSFKASVLEENG-----LREDDYPLLIQRASTLNHLFMFTNQGHVIYRPVHELTDAKWKETGEHISQSIGLADDEEIIKALIFENLELPGTMIFSTSDGQVKQTTIQDLkpgSRYKSRASVVMKLKDASaRMINAEYYEPQAQnvsLTAISKHGYGLRFDVAEVPTQGTRTAGVRAINLKDDDELVNLVQTADDDRLAIMTQRGAFKEMRANELEVGSRARRGVLVLHKLKKHPHEIVDFLAYPADYhgaFEVITDRPEFQDILVDDHHLGTAKSNGTFVIDTDTQGTPVTLRRKITVMANPAKEGSDNKNTQTD----------------
>UniRef50_A5IXX2(9-829:861) Topoisomerase IV subunit A n=2 Tax=Mycoplasma RepID=A5IXX2_MYCAP   E=0 s/c=0.93 id=33% cov=93%
LNDLLSKIIQENLDTVVADRFSRYSKYVIQQRALPDVRDGLKPVQRRILYSMYDLGLQNNKPFKKSARVVGDVIGKYHPHGDTSIYDAMVRMGQEWKMGHTLVEMHGNVGSIDDDPAAAMRYTEVRLSEIANYVIGDIRKNTVKFAPNFDDSEKEPVVMPVLIPNLLINGSTGIASGFATEMPPHNLNEILDAAIAKVKNPAIELTKLAKIIQGPDFPTGGIIYGTEGIHEAFERGKGRITLASRYNVYTDSKY--KYIEITEIPYGVVKSKLVHEIDLIVDSEEVAGLLEVKDQTDRNGINILITLDKEADENVIVNYLFLKTQMRIYYNYNNVVIDNYTPKTLGISALLDAYLKHVKDIKIKTIEFDLIKHKARLEIVIGFLKVAKITDKVIEVIRKSENSK---------------------------------QGVIDNLMSAFDFTLNQATAIAELRLYKLSKTDEHAFLIEKEELEEKIKQCELLLNDSDEFNKYLIALFKDLKSKFGRARRTSIENEqiKASINQEDLVKEEQVFLGISKFGYIKKVSKKIYESNLINTYG-----IKEDDNILFYDNASSLDKLLLFTNFGNYAYLPVFKVHESKWKEFGTHLSDFVDLTSGEELVSAIKVSDFDSSNYVCLFTKKGQGKKVLLKEFDVSRfSKTFVAMKLKSDDELIGAKLSNGLKDVLLITKNNFASLYSENEVPIYGLKSNGNKACYLANYDELSAFAVVSSNDSVVLINANNRAKVVNVSEITKVSKANKGVALFAKSRTNSPIKQCDSLQASSKILIVNNQGQA---HFEKIQDYAKAAYAKFInFDVDDLRTVSLISNYSSDSENSNTHSYDKESAVEEQ---------------
>UniRef50_A9KS51(1-746:748) DNA topoisomerase (ATP-hydrolyzing) n=4 Tax=Firmicutes RepID=A9KS51_CLOPH  E=0 s/c=1.02 id=40% cov=84%
MKKEAENIIQLDFSEEMKTSFRNYAMSVIMARAIPDVRDGLKPVQRRILYSMIELGLDPKKPHRKSARIVGDTMGKYHPHGDSSIYDALVHMTEPYSMQIPLVDGHGNFGSIDGDGAAAMRYTEARLSDGAMTLLDHLDKGLVEFVPNFDESEKEPSVLPAMLPNLLINGTTGIAVGMATNMPPHNPSEVIEGVIAYIDNPDITTEGLMKYIPGPDFPTGGTIINSEDIRNIYETGEGRLKVRAKTEIEA-SDNGRKNIVITEIPYTVagNKTKLVESLVDLMKDKVFDEIFDVRDESSKEGIRVVIEVKKDRDIENLLNGLYKKTSMEDTYGVNLLAVKDQQPIVFKLKNLVGEFVSFQEELYTKEYEHLLDKANKRLEIVDGLIRATDVIDLIIEILRGSSSIKQAKDCLIHGNTTEINFKTEASRKKAAK----------------LDFTERQADAILAMPLSKLIGLEILRLHEENQSLLDSIEQYQSILGNKKELFKVIKSNLKEYKKQFNVPRHTVL-ANMEIAEYVEEVKVEDIYILIDKFGYTKSVDNTSISR-------VSEDNLK--DFV-HIVKMKNTDRLCLFTAQGNMYQVKAEKIPKCKIKDKGTLIHNLCKVDKEEILLYIAFEDLFESQ--LLFTTKNGFIKLVSGIEFETNR-AMISATKLEEADHVVSVlclsahTISNPDSKVILLTEDSLSLGFPLTEVSELKKTSKGVKGITLEKKDKVAFATVALPETEFF----EYQGKELSAKKVRNRKRAAKGQKA------------------------------------------------------------------------------------------------------
>UniRef50_D1BTH4(15-847:855) DNA topoisomerase (ATP-hydrolyzing) n=2 Tax=Actinomycetales RepID=D1BTH4_XYLCX  E=0 s/c=0.89 id=40% cov=84%
-----EKIVDIDVASEMESSFLEYAYSVIYARALPDARDGLKPVQRRILYMMADMGLRPDRPYVKSSRVIGEVMGKLHPHGDQAIYDALVRLAQDFSLRLPLVDGHGNFGSLD-DGPAAPRYTEARLAPPSTAMTAGLDEDVVDFVPNYDNKLTQPEVLPSAIPNLLVNGASGIAVGMATNMAPHNLVEVVAAGQHLLANPAATLEDVMRFVPGPDLPTGGKIVGLDGIRDAYRSGRGTFRTRATARIENITPR-RRGITITELPYLVGPEKVVEKIADGVKAKKIQGVANVQDLTDRtHGMRLVVEVKTGFDPEAVLEQLYRTTPLEDSFGINNVALVGGQPRTLGLLELLRVWVEHRIEVVRRRTAYRLGKRKERLHLVEGLLLAIVDIDEVIQVIRSSDDAGIARARLM----------------------------------DVFDLSEPQATYILDLQLRRLTKFSRIELEKEQSELEKEIAALEEILGSDAVLRRVVSTEMGDVAATYGTPRRTVLLDsaggattsaaaapggargrKPAEISLE--IADAPTHVLLSATGLLArtavapaaaptasegdQLDLDGVALGAPGAPGASGAvsrhgRRHAHDALRGDVMTTSRSDIGLVTTAGRMLRVSALELPSIPPTdgapslSGGIPVSELVELAPGEEALAVVSL--ADDAPTLALGTAGGVVKRVAASDVPSNKDE-WTVIGLKDGDSVVGAAPAGDDDEVVFISSDSSLLHYAASAVRPQGRAGGGIAGISLAAGQTVVFFGVaraaVRPELTVVTVggsagqlpgVGGGSVKVTPYELYPGKGRATGGVRSHRFLKGEDRLV-------------------------------------------------------------------------------------------
>UniRef50_B8DTB4(16-874:982) DNA gyrase subunit A n=23 Tax=Actinobacteridae RepID=B8DTB4_BIFA0   E=0 s/c=0.86 id=40% cov=84%
---VEEHIVETPLAEEMSKSFLEYAYSVIYARALPDARDGMKPVQRRIVYQMGQMNLLPTRPYMKSARVVGEVMGKLHPHGDSAIYEAMVRLAQPFAMRLPLVDGHGNFGSLD-DGPAASRYTEARLAPAALGMNADIDEDTVDFVPNYDNKLKEPTVLPSAIPNLLVNGASGIAVGMATNMATHNLGEVVAAAKYVMKHPDATLDDLMQYVPGPDWPGGGIIIGRQGIRDAYETGRGVVTTRSATHVE-NLTARKKAIVVTQLPYMVGPERVLERISEGVKNHKLDGISGAIDLTDRhNGTRIVIELKTGFDPAAVLAQLFKHTPLQENFAINNVALVNGRPHTLGLRSLLDVWIEHRRGVIRRRSEFRRQKALDRLHLVEGLLLALVDIDEVIRVIRSSDDAEAAKNGLMSR----------------------------------FSLDDIQAQYILDLRLRRLTKMSRIELESERDELQSSITELERILGSAALLDGVVIDEMDKAVATYGTPRRTVLLDEGDDgrlvpvvahgddmpsdaaldaarhaenvldaadavaaarkagETAEALrIEDEPCVIALSASGLIARMSIDALTIW--AKRGAHTEKREPDDVIVSLMPARTRADYALVTSAGRMVLAHVVELPNLEVTGHlsltgGIEATELLTSTestdpvPGERVIATLALRDtvgqddtAAQLPPVGLGTRNGIVKRWNRE--SPTTMDSWSIIDLKDGDELLVAADAHDDDRFVFVSSDSSLLTYEARNVRPQGRTAAGMAGIHLADGCTVLSCAVVahadvewhdaehddagnllspASGAVVLTVagdvdalpgTENGAAKVTPLELYPTKGRATGGVRSQRFLK-------------------------------------------------------------------------------------------------
>UniRef50_C5JAG1(6-721:765) DNA topoisomerase IV subunit A n=1 Tax=uncultured bacterium RepID=C5JAG1_9BACT  E=0 s/c=0.98 id=40% cov=79%
----AEKIEPAAIRGELESRYLAYALSTIISRSLPDVRDGLKPVHRRILFAMRALRLDPGSGFKKSARVVGDVIGKFHPHGDQAAYDAMVRLAQDFAQRYPLVDGQGNFGNVDGDGAAAMRYTEARLTPVAQALLEDLDRQTVDLIPTYDGSQEEPVVLPARFPNLLANGATGIAVGMSTAIPPHNAGEVLAAALHLIRHPDCGVAELMKHLPGPDFPTGGVLVAEpEELREVYATGRGGLRLRARWEQEMVG-HGTWRLVVTEIPYHVQKGRLIERIAQLILDRKCPFLSDVRDESDAK-VRIVLEPRsRGLDPEKIMAFLFKNSDLEVRINVNlNVVTAEARPEVMDLKGLLRAWLDHRFQVHTRRATHDLERIRERLHLLQAYLTVHLNIDAVIAIIKAHDDPAPA---LMQR----------------------------------FGMDSEQAEAVLNLRLRALRRLEEMSIRKEMGEKEARAAELSAMLADPTLMWAAVQDEVKRTRKEFSDGRRTRMAGPAPEIDLrpEDLIQKEPLTAVLSRKGWIKAL--------KGHDIDLEKIRFKEEDGLERAVKGYSHQTVTFLAASGKVYSLLGDRLPSGKR--FGEPLTVLFELDPGDRILWMLAV---DPEGEYFVTTRLGQGFRIRGRDLVANQRTGKQVVSLREGDQPLHVHPVRGAA-VAAISHGRRLLICRLEEFPLLGR-GKGVRIQNLGRGEGLVDAMTFDPQAGLVLDS----GKRT-----------------------------------------------------------------------------------------------------------------------
>UniRef50_Q1RGX8(5-706:736) DNA topoisomerase 4 subunit A n=15 Tax=Rickettsia RepID=PARC_RICBR   E=0 s/c=0.99 id=42% cov=76%
------KIENIDFGSALSERYLAYALSTIMSRSLPDVRDGLKPVHRRLLYAMLQLRLEPNSGYKKCARVVGDVIGKYHPHGDVAVYDTLVRLAQHFSLRYPLIDGQGNFGSIDGDNAAAMRYTESRMTEICTLLMEDIDKDTVDFRSTYDDSDLEPVIMPASFPNLLANGSEGIAVGMATNIPPHNLHELCDALMHLIDHPKAEISDIMNFIKGPDFPTGGIIIDKSDvITSAYMTGRGSFRVRARWEKE-ELNYGVYQIVVTEIPYQVQKSKLIEQIAILLKDKKIPLVSNIRDEST-DIIRLVIEPRdRSCDPQIVMESLFKLTNLESRIQLNMNVIgSNNVPKVMNILEVLQEFLSHRQNIITRRSTYLLNKIKHRLEILEGLRIAYLNLDEIIKIIREEDEPKAI-------------------------------------MMQRFQLTEIQVEAILNTRLRSLRKLEEQEIITEHSNLQKQQAILEEILNNPKELWKVVKKEIKAVQAKFGlnttiGARRTSFEQVTLTnqvVDITAFITKEPITIICSKMGWVRSL--------KGHNNDLSSIKYKEGDAEKFILEAYTTDKILIISSEGRFFTLLADNI--SKGKGTGESIKLLVDIGNND-ITEILV---YKPDHLLLLASSIGKGFVVNSNEVMAQTKSGKQIMNVPDGHTCIACLPVNG-DSVACIGESRKLLVFNIDEIPEM-KKGQGV----------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q6KHI4(4-811:858) Topoisomerase IV subunit A n=1 Tax=Mycoplasma mobile RepID=Q6KHI4_MYCMO  E=0 s/c=0.86 id=36% cov=81%
-NELKDKFLLQSLDGIMSNRYGVYAKYIIQQRALPDVRDGLKPVQRRILYSMHELGLTSEKPFKKSARVVGDVIGKYHPHGDSSIYEAMVRMSQEWKMNVPLIQMHGNIGSIDDDPAAAMRYTEARLSKISSLLLSDIKSDTVSFSLNFDDSEKEPTVLPAFFPNLLVNGARGIAAGFATEIPPHNLGEVIDGIIAKIKNPNIKIETLNTIIKGPDFPTGGIIYGIDGIKEAAFSGRGRITITSKYEVH------KNQIVITEIPYGVVKSKLVRQIDEINLDKNIGGMNEVRDETNRDGIKIVIDLEAGADASKIMKFLMQKTELQLYYSYNNIAIHNNAPVLMNLHDLIQAFLDHVKVIQTNKINFELEKLSKRLEIIEGFIKLTEISDQVIEMIRKSEGSK---------------------------------VGVVENLIKIFNFSEIQAESIANLRLYRLSKTDVEEFIKEKQELETRINFLKTLLSSESEFNAELIKIFKDIKKTYATPRKTEIKDQalKLDVSLSDLIQAEETFVGISRDGYIKRFNQKIHDSNEMQT-----YLLKEDDALIFLSKTLTTGKLLIFTNQGNYISIPIFKIAEEKWKNLGIHLNDFATLLPNEFLIKVLYVDDFSKDFSITLITKKGFGKKVQLPEFEVSRENKSYpAIKFkKDGDELLNAFITNDRLDILLVNTKLEVYKFSENDFKTYGIKAAGVKISDNATKFEISAAIAYSQNDTLVFLTESGHARKIN----------------------------------------------------------------------------------------------------------------------
>UniRef50_D0B2I0(10-715:770) DNA topoisomerase IV subunit A n=40 Tax=Rhizobiales RepID=D0B2I0_BRUME  E=0 s/c=0.97 id=39% cov=77%
--DGEEHIERVDLKSALEERYLAYALSTIMHRALPDVRDGLKPVHRRIMHAMRLLRLNPDQAYAKCARIVGDVMGKFHPHGDASIYDALVRLAQDFAVRYPLVDGQGNFGNIDGDNAAAMRYTEARMTEVATLLLEGINENAIDFRPTYNEEDEEPIVLPGAFPNLLANGSAGIAVGMATNIPPHNVAELCSSALYLINHPDAPVEELVTSpeqwaeieqesktdpaallkckVRGPDFPTGGILVEEHGnILEAYRTGRGAFRVRARWHKE-EGNRGTWVIVVTEIPYQVQKSRLIEKIAELLLAKKLPLLDDIRDESA-EDIRIVLEPKnRTVDPELLMESLFKLTELESRVSLNMNVLSHGKvPNVLSLGAVLREWLEHRKEVLVRRSQFRLAEIEKRLEILGGFLIAYLNLDEVIRIIREED---EPKQELMR----------------------------------AFELTDVQAESILNMRLRSLRKLEEFEIRKEFDDLTAEKTDLEGLLASGTRQWKKISTEIKAVREKFGpttrlGKRRTTFAHAPThdlEDIHQAMIEREPVTIVVSEKGWLRAM--------KGHLADFSTLSFKEGDKLKLAFHAETTDKLLFFTTGGKFFTIGANTLPGG--RGHGEPIRILVDMENDQDILTAFV---HDPSAKLLLVSHEGNGFIVPESEAVANTRKGKQVMNVKAPDEAKLCQRVSG-DHIAVVGENRKMLVFPLSDIPEMTR-GKGVRLQKYKDG--------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A5EV71(8-723:739) DNA topoisomerase IV, A subunit n=2 Tax=Gammaproteobacteria RepID=A5EV71_DICNV  E=1e-180 s/c=0.89 id=35% cov=74%
-----------------EKAYLDYAMYVILDRALPALADGLKPVQRRLVYAMSELGLSAGSKYKKSARTVGDVLGKYHPHGDSACYEAMVLMAQNFSYRYPLIDGQGNWGSADDpKSFAAMRYTESKLTAYAHSLLAELNPETVDWTANFDGTLQEPKTLPARLPNILLNGGSGIAVGMSTDIPPHNMGEIVAACQALLKNPQLSEEALLQIVPAPDFPTGGVlINTREEIAHCYRTGSGSVRLRASYHIE------KDNIVIDELPYQVSGSKVQEQITQQIQEKKLLWLEAVRDESDhKNPTRLVLLPRSHRiDKKRLMQHLFATTDLEKTvrIQLNMIGL-DGKPQIKPLIVILREWLTYREQTVMRRLSYRLHALNERLEILAGLRIAFLQLDTVIQIIREHDDAQTA-------------------------------------LMQALPLTAAQSEAILNIRLRQLAKLEENAIVQEEKTLIDEQKSLQNLIDNRDARLQFIADELAADAQNYADPRRTTFIkpDAKTALPARAWQPSEAVTLVLSKMAWV--------RLAKTHQVDGRTLAYKSGDEFLLQIAAKSDQTAILCGNDGRYYALSLANI--ASARGYGEPLSRYFSFAEKTTIVAAAAL---DPEQYYVLAANNAYGFVVKGSDLVAKTKKGKAVLNVGKANALALLPLFDEESLLCALDNTGRTLIFPARDLPQQSK-GKGNKIM-------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A7VBP9(1-756:759) Putative uncharacterized protein n=2 Tax=Clostridiales RepID=A7VBP9_9CLOT  E=1e-178 s/c=0.83 id=33% cov=80%
---MSEKILNVDYESEMGQSYVDYSMSVITERALPDVRDGLKPVQRRILYSLNGLA-GSDKPHRKCARIVGDTMGKYHPHGDSSIYEGLVNMAQNWKLPIPLVDPHGNFGSVDGSGAAAMRYTEARISKYTEDVcMKDLSFFKDQFIPNFDGTETEPTFLPFQVPNILVSGSTGIAVGMATNIPTHNLGEVIDATVMYLNDPEVPLENLLDVMKGPDFATGGIINaSKEDLMQVYETGLGRIKVRGKVEI-RDIGHGRKSICVTEIPFTMigGTAKFLDTVAELTRNRELPAVVDIADRGDKNGECLCIDVKKGTTDEEirnIINILYKKAGLEDTFGVNINCIYDGKPEVMGLRRILSIYTDFKYGLYNTKYTKLLENQMEVREIKTGLLTAVDCIDLIIEILRGSKKVADAKACLMHG----------------DTSNITFRFKGSEADAKFLCFTEKQADAILAMRLQKLIGLEVNALKKELEDAEKLIKKYSKLLESKSNMKKQMIADMLEIKEKYAIPRKTVIADCGEVVVKKAQAVETEVAVLLDRFYYIKVVDANLYDKNKAQI---------DKDY-RFSFKCKNTERVGVFADNNQMYMIKVADIIKlqakkntgkkgngsgliGRLSDKGIQIFEFCNMNGNENILYMCCLEQIID-KNLLFVTKHGQAKLVPGNNYDVLRK--MIAASKQEED-IIFIHDAEMEDFIVVKSMLGYYARIQISEIPVKGKGAGCIRLVNITDDDEI-----------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D0RNU6(1-731:746) DNA gyrase subunit A n=1 Tax=alpha proteobacterium HIMB114 RepID=D0RNU6_9RICK  E=1e-172 s/c=0.83 id=38% cov=75%
---MSKNIVKDELQNQFAKKYLAYALSTITQRALPDVRDGLKPVHRRLIYAMYLLNLSPKSQFKKSARVVGDVIGKFHPHGDQSVYDALVRLAQDFSTHYPLVNGQGNFGNVDGDNAAAMRYTETKLTKTSEYLLADIEEETVNFKKTYDGELDEPEILPSQFPNILANGSSGIAVGMATSIPPHNVQEICEALIYLNDNPNCSIKDLLKFIKGPDFPTGGILNeDKKEIFKAYKTGRGFFEIKSKYKVE-DLGRGLYQIAVTEIPYSVNKSKLIEKLAGIIINKKNKLLDHVSDESD-EKIRIVLRPKnRNVNPEDLMNSLFEQSELKNKIFLNMNVLNEkNEPKVMNLKEILKSLLKHRYIILNNKINFKLKKIKRRLEILKGFIIVYKNLNQIIKIIRNSKDP---KKELIKK----------------------------------YKFTLIQVDSILEMRLRNLKKIEELDIKKEFKNLELEKKRLSKILNSKTLQRKEINNEYTEVINEFGDnstygPRRSILEKFVKFTDDElesKLEVIENINVSLINEKFLK------------SKKGTYKRSEKNSDDVSLIINCKTSDQICLLSNIGKSYILNCSNLKFGS--TKGFLISSYLKLKDEEKIVDLFV---YKEKQEIILSSQNGYGFFVKSEDLFTNKKSGKKIFNIKKNDQFYGSCLINKEKDkfIVLFLKDNlkyKLIIFELKEVP-------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A7AVY4(93-1028:1051) DNA gyrase A subunit, putative n=5 Tax=cellular organisms RepID=A7AVY4_BABBO  E=1e-171 s/c=0.65 id=32% cov=89%
--ELLHTVQDLELCDELSQSFMKYALSIILGRALPDARDGLKIVHRRILWAMQVMKLGASTPYRKCAKVVGDVLGKYHPHSDKSVYDALCRLSQLFMMRVPLVDGHGNFGSTD-DPPAAMRYTECRLSPFSEKlLLAEMGKNTVDMLPNFDSTEMEPTVLPSKVPLLLINGSSGIAVGLATNIPPHNPEEILKAASLMAKNhGNVDTEELLNIVRGPDFPTGGHIVtSIDALRKIYTTGKGSIMLQAKYIYEERIKprnskresdvvvntysdpshlsftsGSRVSIIVKELPYNVRLSDVMLAISKAVETGALRGISDLRDESDRGGLRLVIELKKHItthlEVEEIMQKLKKMSGLCSFFKCNFIALDssGTKPVRLSLYSALKIWLEFRVQTVRKRIERQREQAKERLNIVKGFAIAFNKIDDIVHMVRNSSSSAEAMRMLSEKRYG--------------------------------GLNAEQASAVLRMSLSQLSRIERDKIDLEEKELSESIKRYNHILGDESHIYSLIYSELEHIRqnpEKHYTVRhrcttlsvsgHTSLGDGDVAQDYppelggndeefvdsisatiaEDHIAnepgndpgdlvkqnpdleghnphDEPSLIVMNNYGLMQRIKLDNsfFRSQKSryipssrlqqpyqgqysigeGENEDVAPEITQSELQLHYGVCRPGDSCMMISKDGTCFVLPVSALRLC---NKGYSIWKQVKLKSPENVEYFTVTSKllfsqdqnsgvsncmyklimDETTSYLVLIFTDGQVGIISTKHFPSghLYKNPLIRLRLWNNKELkpIFAMFCCPDDDIFVGTLRGYSLRVRLNDLlggmehRGKTRK----KLIKLKENDKVTCGAILEslsnvendakeicrfenyDNRHLLLLSEHGRAKLLHISELQLRRHGGYGYNITRQSSSTiEGLYAATVVDTDDDILLVSKDGLLARKDPFTLPVASR----------------------------------------------------------
>UniRef50_B1BBK7(662-1413:1417) DNA topoisomerase n=5 Tax=root RepID=B1BBK7_CLOBO   E=1e-153 s/c=0.73 id=30% cov=82%
----FDNEQEKDIVKVLNENYLPYAIEVIKERAIISI-DGFKPAHRKLLWTLHESNLYNKR--TKSAHIVGSNMS-LNVHGDGSIYETLVRMAQKDTLLYPYVNGKGNFGQHTSKSlqNAHMRYTEAGASNINKEFFHGINKNAVDFVPNFDGEKEEPILLPTTFPNVLVNANKGIAVGMASATPSFNLKEVCDLTIAYIKDTNIVVSD---YLLCPDFATGGFIVrDVDKLNQIYETGQGSVTLRAKYEVK------DNEIIVTEIPYTTNRESIVKDIKTLCRESKdniIRNITNVIDSTDRKGMSITIKIKKNTNIELLMEKLYANTKLQDSYSLNMnIVCLDKIPRVLSIKRILDEWLKFRRMCISRVSNYDKKDKEHKLHLLNAFKIILTDIDALVHITRNAIDDDDMIKQLQ----------------------------------LYFKIDQEQAEYVSNIKLKKLNKNNIIEItEQQITALQQEISDLKNIQNDETRINNIIIQQLQNIRDKYKIPRKTEIinVEDIPSVTLEDIkIEDFNPTLVLTEQQYIKKNRVFS-----------QSQKLKDDDKILQFHQCNNKDDLLLFTNKGNVLIRKVYELDEHKPSTYGDFLPNLLGehLENDEKVIYISTTKNYKG--SVITVFENGNVARIDLKQYKTKQNRQVPMDAYNTDSKLVSISVITDDTNILLVSQEGKALIINTSQIRPTkSRNTQGVAGMKIDtEHNKVIGSIIgVTVEDNFDIKTEKSKSKfimlddiapngKQSMTEYLKGNRNTQGNFIYNTRQKHDKVI-------------------------------------------------------------------------------------------
>UniRef50_Q8I0X3(174-1115:1222) DNA gyrase subunit A;evidence=inferred from direct assay n=9 Tax=Plasmodium RepID=Q8I0X3_PLAF7  E=1e-145 s/c=0.55 id=31% cov=83%
---------DVEICEILSKSFLSYANFLILNRCLCDYRDGLKTVQRRIIWSMYEINKGIDKKgYKKCARIVGEVIGKYHPHGDKSVYDALVRLAQKHHNNNLLIKGYGNFGSVEY-NAAAMRYTEAKISSFCYDiLLDEINDENVEYIKNFDGNEREPKVLCSKIPLLLINGCSGIAVSILSSIPCHNLIDVANCCINFLINENIRDDELFHIIKGPDFSTGGIIISKYDIlKNIYNSGKGNFEIRSNVFFEYIKNDKKvitkhindlssiensdidkltKKIIIKNLPPNVKPNELIENIINLLNDKKNEHdniLLRIRDESEKEDMRIVLELKKHSQIEQIHNflsYLFKYTNMQISYHCNFVCIgYENTYTQFSLKSFIKLWCNNRIKFIKTNYEIKNKNLQKQLNIIDLYLIIQNKILDIITFFQKNQNIEQIQLYLK----------------------------------NNFKLNPEQIKYILSIKLQKLINIKNIDFISQRNKIMHQIKLNDEIINNVQNIKNLIIQELIYIKNKYGIhnlnkqciipstpkykysyinseyhpnfsknkqiidtyntvstndnninhsnythdlpntdnvtkdknvvetnvhknihissdisnniknsdknssltknqdsdnmmpYRNTYI--DSLDNNMKDIYNNDEVLILITYGGYIKKIKINEKLKNHSNNiiklsnvkyilkeneeklnennkrlkfndlqKGNEQEKYKDNEQklnndighniniqnnnndnnnnnndnnnvlllneeeynsykIKKSILVRNRDKILLTDNYNKAFLLNVYDLHLSSYDSKGTPINQIIHSSKN--ITGITKFQE--NKKYLIVCSENGKMKVINNDVFLKRKKKG---IKLFKNKKNIYFSYCNFNDNCIVGTKNGYIIQFPLSSFKISKKNSLGNKCISLAKNDKVVDLLSYENNEknlknyKIIFVTKNGFGKMINLNELKIQKKKGKGHRIMKFKK-------------------------------------------------------------------------------------------------
>UniRef50_B1ZME1(62-689:708) DNA topoisomerase (ATP-hydrolyzing) n=2 Tax=Opitutaceae RepID=B1ZME1_OPITP  E=1e-124 s/c=0.71 id=25% cov=69%
--------------------FLDYASYVILDRAVPHIDDGLKPVQRRILHTMWEM---EDGRFHKLANIVGATM-RFHPHGDASIGAALVGLGQ----RGFLVEPQGNFGNlLTGDDAAAPRYIEARLTAFAKDVL--FNPKTTPWQLSYDGRAREPVTLPAKFPIVLLEGAEGIAVGLATKILPHNFNDLCRAAINHLQGKTFRIY--------PDFPTGGVADFSE-----YNDGErgGKVKIRAKIEI-----RSKYLLAITELPFGSTTESLIESILAANAKGKIK-IRHVDDNTA-DAVEILVHLPQGSDPEKLIQQLYVFTACQTNLSPAACVIEDDKPHFLGVREILKRSVDKTKALLKRELEIRQAELEQQWHW-------------------DSLERIFIEERIYRRIEKSKTWQSVLDEIREGLQPFLKQLRRPVTDDDITRLTE--------IRIKRISAYNRFQADEAIKKIEAELRETK---ANLKALTAYAVAWFEQLQEKYGKglKRRTS-YDEIEQINAAE-------VVSANQRLYVNR------------EDGFIGLNWRQHEYVQD---CTILDSVVCLMRDG---SLKVSKVAE--KVFMGRDIIH----------CAVFPKDGDPNFYTMVYQdkeSGKAFAKRFQIGGLSRDK---LYSLVKSEGSRVVYLEISKTEKEmpkklrIFIDGRSGARVRefdFELDRVPVSSRSAKG-----------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B9PK68(775-1267:1688) DNA topoisomerase 2 n=3 Tax=Toxoplasma gondii RepID=B9PK68_TOXGO   E=1e-110 s/c=0.81 id=25% cov=49%
-----------------------------TERSIPQLVDGWKPGQRKVLFACIKKNMKH---ELKVAQLAGYVSevSAYH-HGEASLQQTIVTMAQRFvgSNNLNFLEPVGQFGSRkeGGKDASAARYIFTRLAFYTRLVFHEADDPILEYEY-EEGQRIEPKMYVPVIPTVLINGSEGIGTGWSSFVPNYNPRDVIENLRRYIDGEEM-----------------------QRMTPWYRGFRGRIEENAAGtgfeTIGLVRRCGEDSYEITELPIKRWTQDYKEWLEENLPtaEKRDTLIADYRDCSSHEEIHFTVKVGEERVERPEREGLEKYFKLKSSLSITNLTLFDphgRVQRYANELEIIKEFAPIRLEFYHRRKAYCLAMLEKARRILSNRLRFILAVVNG-ELIINNKRKKALIEELFSQGYDPMKEIEDAANAGIRAALKRDVIVDDEALAEGGeeeeeivaGCTAKHYDYLLGMPMWSLTLEKVEDLRGEMRQKELELEELR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C3YYJ6(157-726:1181) Putative uncharacterized protein n=1 Tax=Branchiostoma floridae RepID=C3YYJ6_BRAFL  E=1e-106 s/c=0.68 id=25% cov=49%
-------------------------------RSIPSLVDGLKPGQRKVLFTCLKRN---DKREVKVAQLAGSVaeMSAYH-HGETSLMGTIINLAQNFvgSNNVNLLQPIGQFGTRihGGKDAASPRYIFTMLSTLARKLFNTFDEPMLNYQYD-DNQKIEPEWYIPLIPMVLVNGAEGIGTGWSTKVPNYDVREIINNMLRMIDGKD----------PLPMNPS-------------YKNFKGDIEELEENRFVANGEVailDNNTIEITELPIRTWTQNYKESVLEVMlhgTEKTPSMITDYKEYHTDTTVRFVVSMTEEQLMKAEAAGLHKVFKLQSNIASTNMVLFDHNGclrtynsvhqilqeffdlrlqwflnclfvvcllflwvlfdhngclrtynsvhqilqeffdlrlqwflnclfvvpvlfdhngclrTYNSVHQILQEFFDLRLEWYTKRKDWLMGMLEAEASKLNNQARFIlEKIEG--KLVIENKPKRELIQMLQARGYDSDPVKAWKETQNDKDKPDDLLDVEEEEAESVASSTAsrggPDYNYLLGMPLWNLSREKKEELLKQQREKGQELEDLR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A7TEE2(665-1157:1404) DNA topoisomerase 2 n=1 Tax=Vanderwaltozyma polyspora DSM 70294 RepID=A7TEE2_VANPO  E=1e-103 s/c=0.77 id=23% cov=49%
-------------------------------RSIPSVLDGFKPGQRKVLFCCFKINLTY---EIKVGTLAAKVSEKtsYH-HGEESLQQTIVGLAQNFvgTNNIYLLKPAGSFGSRatGGKDAAAARYIHTQLNKVARSIFHPSDDALFNYLED-DGSPIEPEWYLPIIPMVLVNGAEGIGTGWSTNIPSFNPLDIIKNIRHLMNDE-----------------------VMDEMYPWYRGWKGvvekvddhRFRLYGKVE-----QVGPNVLEITEVPARTWTSSIKEYLLLGLsgNEKTKPWIKDMEEQHT-NDIRFIITLTPEEMAKTKKIGVYDRFKLVSQVNLKNMVAFDahgKIRKYDTVLDILTEFYYVRLEFYQKRKDYMSQKLQWTVEKISFQVKFLKMI-----IDKEYTVSNKAKKIIMKELEGFGFPRINKDGKPHYGSVKIEEIEEGNEIEEGNANEEQDdtvhkpsdivgsYDYLLGMKLWDLTMERYEKLRAQKQEKEIELETLLKL--SPKDLWN---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B7XIW3(638-1078:1159) DNA topoisomerase 2 n=1 Tax=Enterocytozoon bieneusi H348 RepID=B7XIW3_ENTBH  E=1e-99 s/c=0.83 id=25% cov=44%
-------------------------------RSIPSVIDGLKPGQRKVIFSCFKRNL---KTEIKVAQLVGYVSehSAYH-HGEASLAATIINLAHDFvgSNNINLLLPLGQFGSRllGGKDSASPRYIFTNLNPLSRLIFHEHDIPILESQI-EDNLVIEPTYYVPIIPMVLVNGTDGIGTGWSTNIPNHNPLDLIKNIKRLLNNQEP-----------------------EEMIPYYRNYKGTITKINAGKYISCGKvfenINKKEINVVELPIGVWTQAYKEYLDQAIADNV---IKSFKDYSTDKTIDILIHMNNNEFS----------SKLTTSISTNNMVCFDrngKIKKYHNTLEILKDFYEVRLEFYNKRKIYRLKLLADELNKLKNKVRF---IEGVItgSIIITQRPLNEIILELERKEFTRYDN----------------------------------YEYLLDMKISSLTKEKINKLREEYNNKNIEYNELK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q5CB96(291-652:652) ATP-dependent Clp protease, ATPase subunit n=1 Tax=Thermotoga sp. KOL6 RepID=Q5CB96_9THEM  E=1e-95 s/c=0.98 id=36% cov=41%
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KLVKKISEVKEILEKDVKVKEIMKKEFKYLKERYGDPRRTKITDEELRYDMEELIAEEDIVITLSHKGYLKSTPLSSYRSQRRGGKGITVSKLSEDDEVEFVVVTKNISSTLFITNLGKAYVLKNYQIETTGRNTRGRHISAFLNLEETEKVVALAPLNG--KGKDLVIVTKHGKIKRTALEEFENaTSNRGVRAIRIEAGDEIISARVIDSErGSLVVATKLGMVIRFPVSDVRRMGRNAAGVQAIKLQPDDEVVSMDVVpsENEGEILTVTEKGFGKRTPVELYRIQKRGGTGLRNISDVKKTGYVVAVRYVRGDEEIVVVTKNGMMIRIPVSDIGIIGRITKGVKLIELGD-DSISKVAVVK-----------------------------------
>UniRef50_O24308(668-1151:1462) DNA topoisomerase 2 n=3 Tax=fabids RepID=TOP2_PEA   E=3e-94 s/c=0.72 id=22% cov=44%
----------------------------------------------------------------------------YH-HGEQSLASTIIGMAQDFvgSNNINLLKPNGQFGTcnLGGKDHASARYIYTELSPVTRCLFHEHDDKLLEYL-NEDGKSIEPNWYMPIIPLVLVNGSEGIGTGWSSYIPNYNPREIIANVRRLLNGEELVPMD-----------------------PWYKGFRGTIEKSAKeggyIVNGTVTEIDEQTFRITELPIRKWTQDYKqflESITDGAPNVKDPLIEDFRQNGDDAIVDIEIKMKPEKIATILQEGLFKKFKLTSTISTSNMHLFDaeGNKKFDTPEQILEEFFPLRLDYYEKSKEYILGNLNRLLLILDNKVRFILGVVNG-EIIVSNRKKAELLIELKEKGFTPMPRKGKSTKpqvaganDDDSEEQEDAEPETASQSVSVEGATWGDYDDLLSLPIGTLTLESVQKLLDEKTEKEKE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q252N7(2-466:479) DNA gyrase subunit A n=9 Tax=Chlamydiales RepID=Q252N7_CHLFF   E=7e-94 s/c=0.75 id=27% cov=52%
-----------DVSDLFKTHFMHYASYVILERAIPHILDGLKPVQRRLLWTLFRM---DDGKMHKVANIAGRTM-ALHPHGDAPIVEALVVLA----NKGYLIDTQGNFGNpLTGDPHAAARYIEARLSPLAKDIL--FNTDLMSFHDSYDGREKEPDILPAKLPLLLLHGVEGIAVGMTTKIFPHNLYELIEAQIAILNNRTFTLL--------PDFYSGGVMDASE-----YQDGLGSITIRASIQI-----VDSKTLIIKEICPSTTTETLIRSIENAAKRGVIK-IDSIQDFSTDQP-HIEIKLPKGIYAKDILEPLFQYTECQVVLTSKPTAIYNNKPVETSISEILKLHTEALEGYLQKELQI-LHDELAQEHYYKSLEYIFIK-HRLYDIVRE----------LLSKLGNKVSQEDLHEAVLASLAPFISSLPEAPCKQATSQLASLAIKKIL--------CFNETSYTKDLEGIKKKQTAVKKDLSN---MKKFTIKYLKGLLAKYGElgKRKTQI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_P90520(785-1241:1284) DNA topoisomerase 2, mitochondrial n=1 Tax=Dictyostelium discoideum RepID=TOP2M_DICDI  E=3e-90 s/c=0.74 id=25% cov=36%
-------------------------------RSIPSLIDGLKPGQRKILFASFKRRLTN---EIKVSQLSGYVAEQtsYH-HGEQSLNSTIVKMAHNFvgSNNLPLLTPSGQFGTRlqGGSDSASARYIFTKLEPVARYLFNELDDPLLNYLE-EEGESIQPDYYIPIIPMLLVNGSEGIGVGMSTSIPLFSPIDIIDQLMLRLNNQ----------------------VALKKLIPWYRGFKGTISPdRHTYRTNGVIKLVGRNLEITELPIGRWTSDYKEVLNDLIDK---DVIKSFQESNTENSVHFTILLNNnqlEQMEDLTENELIKLFKLSASLNFHLTCFDENSKiqKLESVEEIIDQFYKVRLQFYGKRREYLLK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q55BP5(746-1300:1521) Probable DNA topoisomerase 2 n=1 Tax=Dictyostelium discoideum RepID=TOP2_DICDI  E=4e-89 s/c=0.60 id=23% cov=48%
-------------------------------RSIPNIVDGLKTSHRKTLYSCFKRNL---KKEIKVAQLIGYVSehSAYH-HGEASLYSTIVGMAQEFvgSNNINLLNPAGSYGTRiaGGKDCSSARYIHTRLNDIARAVYHADDDPILSCVVD-DGKKVQPKFYIPVIPMILVNGCVGIGTGWSSTIPNYNPRDLIQNMRLAIDGKPLKP-----------------------IKPWYRGFLGSIEANQGSKVQGGqylskgiwKKLSDNRFEITELPIGFWTQDYRELLDELEtpgtrkkkkeekekkaasrkgtkakptttkRSKRVDDdddnekvteatVKSYTNYSSESTIHFIIDTIQPVDE----INIEKVFKLVSTINETNMVVFDeeGRIQRFATTTALQEhFFPLRIKHYQMRKDFLSERLSEEYSRLSNkarFILAVVNKELVISNVKKVDLINKLKEMKFDRIINKNSNKSARDKIKKKKNAFDEEDAAISSDEEKDGAQEEQdddtkgYDYLLSLPLWSLTLERVKKLIEERDSKKKE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A8Q6X4(714-1160:1178) DNA topoisomerase 2 n=1 Tax=Brugia malayi RepID=A8Q6X4_BRUMA   E=8e-88 s/c=0.73 id=25% cov=48%
-------------------------------RSLPNVVDGLKPSQRKVLFTMFGR---YERGEIRVSQLAGAVSQycGYH-HGEESLVNTIVRLAQDFvgSNNLNLLLPLGQFGTRlsGGEDVASARYIYTSLSPLARAIFPHPDDKVLK-NLVEENALVEPEWYCPIIPMILINGAEGIGTGWATKILPRCPRQVISNAQRLIDGRPLQDML-------PHF------RKFQGT--IYETAPRQYSISGKVSYRRLKSGLRA--IITELPTGIWNNKYKEKVLDsAIKNGIISNYEELHTESNVHFILHVID-KPLLSDKKQIKALNRLLKLRSVASENSMILFDEKNvlqKYDSTREIFQEFFEVRRQKYIERRECELVIMEGKLKFIENQVRFVNAIING-EIIIKKKNRAEIIAQLAEKGFDSNPMKAKNATDG--------------------NCNPPDFAYLLDMPLCRLSNEEILVLQEKRSQLWERFKSLKS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q5UQE6(713-1212:1263) DNA topoisomerase 2 n=3 Tax=root RepID=TOP2_MIMIV   E=7e-81 s/c=0.61 id=24% cov=47%
-------------------------------RSVPNLMDGFKPSHRKVFYGSVEKNIY--KQEIKVSDLTGFVsnMTKYH-HGDQSLSSTIVGMAQNYvgSNNLNLLMPLGMFGSRltGGKDSASPRYLNTKLDDLAKKIFIDYDFDILQHQ-SEDNCRIEPVYYAPIIPMILVNGAEGIGTGYSTKIYPCNPRDIIANIKRLLTNENPKTMK-------PWFRhLTGTIEKIDGA---------KYISRAKYEI-----IGKDTIHITDLPVGIWTDNYKAFLDNLIvqgtaqnaEEKKaskavssakntktttkagsktgsrtrknpalakksqksvtakvakknpvASSIKTYSEDCTDIRISFTIVFHPGKLDTLIKSGkLDTGLKLVKPLNLTNMHLFNEKgkiKKYDTYGAILRNFVKVRLNLYQKRKDYLLGKWKKEMDILKWKVKFIEyVIEGKIVIFKNGKSKKK-------------------------EEVLKALEDLKFPKFIVGNESYPSYGYITSIGLFNLTLEEVEKLKKQLADKKQELAILEA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_P07065(2-384:442) DNA topoisomerase medium subunit n=8 Tax=T4-like viruses RepID=TOP5_BPT4  E=1e-79 s/c=0.79 id=31% cov=29%
------QLNNRDLKSIIDNEALAYAMYTVENRAIPNMIDGFKPVQRFVIARALDLARGNKDKFHKLASIAGGVADlGYH-HGENSAQDAGALMANTWNNNFPLLDGQGNFGSRTVQKAAASRYIFARVSKN----FYNVYKDT-EYAPVHqDKEHIPPAFYLPIIPTVLLNGVSGIATGYATYILPHSVSSVKKAVLQALQGKKVTKPK----VEFPEF--------RGEVVEI----DGQYEIRGTYKF-----TSRTQMHITEIPYKYDRETYVSKILDPLENK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q76Y98(2-438:438) Gp52 topoisomerase II medium subunit n=1 Tax=Aeromonas phage Aeh1 RepID=Q76Y98_9CAUD  E=2e-79 s/c=0.69 id=26% cov=45%
----------------------EFAMYTIEERALPSMVDGLKPVQRYILFSVLK---NAGREFKKNAAVAG-VISEYgYNHGEMAAMDAACLMASTWNNNFPVIQGRGNFGCRAVQEGAAARYIFCSKHERFESMFK--DMELLE-ESTADGSIL-PRYYLPILPTVLLNGVSGIATGFATKIMPHSVQSVAKCVEQVLKSGKCDEPE----IQFPKFF--GKILSIEGETQ-------SWKVEGDYEL-----SGKTKLIINELPPKYDRLKYVTHLNKLVETDKIVGY----DESKMKDREFCFKVTLKRDFDVSHENIIKVFKLSQNVSQYIRVIDqNGNLKpYDNASDLIVDFVNFRFNVLQKR------------------------IDNAIIATREKLDFAQAKVDFIKLVLADKIVFNRQTRKQVIEQINAFDELKTY------------ADQLVQMNLYHMTEDEVAKLEKQVAELQKE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_UPI0001B4252C(1-287:288) DNA gyrase subunit A n=1 Tax=Listeria monocytogenes FSL J1-175 RepID=UPI0001B4252C  E=8e-78 s/c=1.02 id=36% cov=32%
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DTLLFFTNTGKVYRSKGYEVPEYGRTAKGIPIINLLGIESQEQVNAVINLSEFTDDSYLFFTTKHGVVKRTTLSQFAKIRQSGLRAVELRENDELISVQMTDGSKNMIIATKHGQSIYFPEENIRVMGRTAAGVRGIRLREDDEVIGMEVLEDDEKVLVVTEKGYGKQTPASQYPLRNRGGMGVKTVTITEKNGNLVAMKTVTGEEDLMLMTVSGVLIRFEIDTVSQTGRSAMGVKLIRLDEDEKVATVAKVPKEEDEVELEEeidetliTQVPDESFEDAPGSDIE--------
>UniRef50_C9DGJ0(1-448:449) Gp52 topoisomerase II medium subunit n=1 Tax=Deftia phage phiW-14 RepID=C9DGJ0_9CAUD  E=2e-57 s/c=0.51 id=20% cov=48%
--------KEISISQHIQGDHKAYATYDNQ-RNIPHIADGLKPSLRKIIHTAIET--MRGKEEVKVAALGSRAsdLTEY-GHGEDSIIDAVVTLGRNYrgTNNLPLLQKQGQFGTMVDNDASEPRYIHVSRHANLSHCFKEEDRAILDFQVS-EGKTIEPVFFLPPLPLVLINASSGVGNGYSSKILPRSPQALIEMSKAILNETPINPEWSL-----PHFP------GFKGRVKA--TGPCSYEIHGAIQLNPKAKTEFTII---DLPPdsKYQYEQFKEReLLPLLDSKT---IKNFESDSTEQAWSIKVQSTREFAQHPE---LVKRMGMILRVTENLTVWtWDGQLKRYPTAEaLLRDWLVGREYYMEKRRQSEIARSTKEMNWL-----------------------------LVKVEFLKWWNANHNQAVR---MSNDEIKSSFTSTLGDLKFDDEMLSKLLALPVSSLKMSGIEALQNAHDEVE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q00942(703-1188:1192) DNA topoisomerase 2 n=7 Tax=African swine fever virus RepID=TOP2_ASFB7  E=4e-53 s/c=0.44 id=22% cov=25%
----------------------------------------------------------------------------YH-HGDMSLNTSIIKAAQYYpgsSHLYPVFIGIGSFGSRhlGGKDAGSPRYISVQLaSEFIKTMFPAEDSWLLPYVF-EDGQRAEPEYYVPVLPLAIMEYGANPSEGWKYTTWARQLEDILALVRAYVDKDNPKHELLHYAIK--------HKITILPLRPSNYNFKGHLKRFGQYYYSygtYDISEQRNIITITELPLRVPTVAYIESIKK--SSNRMTFIEEIIDYSSSETIEILVKLK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C4UA00(1-250:265) DNA topoisomerase 4 subunit A n=9 Tax=Bacteria RepID=C4UA00_YERAL   E=1e-28 s/c=0.52 id=20% cov=21%
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MSEHDIVPSEPVTIVLSEMGWV--------RSAKGHDIDPSGLSYKAGDSFRAAARGMSNQPVVFIDSTGRSYALDPLTLPSA--RGQGEPLTGKLTPPPGAAIEQVLMAP---DDQKLLMASDAGYGFVCTFNDLVAKNRAGKTMITLPENAKaLPPLEIHGPDDMLLSITAAGRMLMFPVADLPELSK-GKGNK---------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_P0C0R0(1-843:893) DNA gyrase subunit A n=296 Tax=cellular organisms RepID=GYRA_STAES   E=0 s/c=1.23 id=51% cov=96%
MAELPQsRINERNITSEMRESFLDYAMSVIVSRALPDVRDGLKPVHRRILYGLNEQGMTPDKPYKKSARIVGDVMGKYHPHGDSSIYEAMVRMAQDFSYRYPLVDGQGNFGSMDGDGAAAMRYTEARMTKITLELLRDINKDTIDFIDNYDGNEREPSVLPARFPNLLVNGAAGIAVGMATNIPPHNLTEVIDGVLSLSKNPDITINELMEDIQGPDFPTAGLVLGKSGIRRAYETGRGSIQMRSRAEIE-ERGGGRQRIVVTEIPFQVNKARMIEKIAELVRDKKIDGITDLRDETSlRTGVRVVIDVRKDANASVILNNLYKQTPLQTSFGVNMIALVNGRPKLINLKEALIHYLEHQKTVVRRRTEYNLKKARDRAHILEGLRIALDHIDEIITTIRESDTDKIAMASLQER----------------------------------FKLTERQAQAILDMRLRRLTGLERDKIESEYNELLEYIKELEEILADEEVLLQLVRDELTEIKERFGDERRTEIQlGGLEDLEDEDLIPEEQIVITLSHNNYIKRLPVSTYRSQNRGGRGIQGMNTLDEDFVSQLVTMSTHDHVLFFTNKGRVYKLKGYEVPELSRQSKGIPIINAIELENDETISTMIAVKDLEsEEDYLVFATKQGIVKRSSLSNFSRINKNGKIAINFKEDDELIAVRLTTGNEDILIGTAHASLIRFSESTLRPLGRTAAGVKGISLREGDTVVGLDVADseSEDEVLVVTENGYGKRTPVSEYRLSNRGGKGIKTATITERNGNIVCITTVTGEEDLMVVTNAGVIIRLDVHDISQNGRAAQGVRLMKLGDGQFVSTVAKVNEEDDNEENADEAQQSTTTETADVEEVVDDQTP---
>UniRef50_Q1IH79(20-863:865) DNA gyrase subunit A n=5 Tax=Bacteria RepID=Q1IH79_ACIBL   E=0 s/c=1.22 id=48% cov=95%
----PQNIQPINIEEEMKRSYLDYSMSVIIGRALPDVRDGLKPVHRRILYAMHDMGLLHNRKHVKCAKVVGEVLGKYHPHGDSAVYDAMVRMAQDFSLRYPLVDGQGNFGSVDGDPPAAYRYTEARMTAIAEELLADIDKDTVDFVANFDDTSAEPLLLPTKVPNLLINGSNGIAVGMATNIPPHNLTEIVDACITIVNNPKSTLDDVLKFVQGPDFPTGGFIHGKGGIKNAYQNGRGRFMMRAKVAVEH--LPNKDAIVVTEIPYQVNKSTLIKKIADLVNDKTIDEISDVRDESDRDGMRIVIELKRSAQPEIVLNQLYKHTQMQESFSMIFLAVVNNQPKEMGLVQALNHFIDHRIDVVRRRTFYLLQKAKDREHILEGYLMALDHLDNVIAIIRGSSNRADARENLVAYFTGKKITINTTGKAPKVDPEK--------------PFSTRQADAILELQLHRLTRLSIDEITSELKDVRERIAEYESILASEKKLRSVIVKELEQIRKDYGDERRTIIQDEAAELSLEDLIADEQVAVTVSHSGYLKRTPISTYRQQRRGGTGRKGMSTRDEDFVEMMFVASTHAYLLIFTNTGRVYWLKVYEVPEIAAAGKGKHIGNLVALQPGESVRAILPVKSLEEEsRYVFFTTRKGTVKKTALVDFSNVMARGIIAIGIDKDDELVAAQLTDSNQIVFLASHEGLAIRFDEADVRIMGRPAYGVRGMDIGAKDYIVGMAITPKERKkgknggadtanlILSVTENGYGKRTDVDEYRLQTRGGKGVINVKTTERNGKVVAIMLVTEDAEAMVISQYGKIIRTSTDSIREAGRSTQGVRLLHLEPGDKVAAAVVIPDDEKAEAEPTL------------------------
>UniRef50_A1V9C1(24-853:856) DNA gyrase subunit A n=18 Tax=Bacteria RepID=A1V9C1_DESVV   E=0 s/c=1.19 id=50% cov=94%
--------QQISIEKELRKSYLEYSLSVIIGRAIPDVRDGLKPVHRRIMFAQHELGNAYNRPHKKSARIVGDVIGKYHPHGDSAVYDAIVRMAQEFSMRDPLVDGQGNFGSIDGDAAAAMRYTEVRMSRLAGEFIADIEKETVDFRPNYDNTLLEPVVLPTRVPNLLLNGSTGIAVGMATNIPPHNLGELCNALLHLLDDDACTIDDLMDHVKGPDFPTGGFVYAGQGLVDAYTTGRGTVKVRGKVEIE-ERKKGFQAIVIREIPYGLNKSSLVEKIAALVNERRIDGVADLRDESDRKGIRVVIDLKRGTIPDIVVNALYKYTPLESSYGINMLAVVDNRPQLLDLKSALSHFLEHRREIIIRRTRYDLRKAEARAHILEGLRIALDNIDEVVALIRASATPQEAKDRLMQR----------------------------------FGLSEAQSQAILDMRLQRLTNLEHEKLLDEYRELLKKIEYFRSILENIEVLRQVMREEFTEIRDTYATKRRTEVLMDELEgIAIEDLIPDDDVVITLSRRGYIKRTTLDNYQQQRRGGKGIAGLHTSDDDFVQEFLTTTNHQYLLLFTNHGKMHQLKVHQVAEGSRTAKGVHIANLLPLEKDEWVTTVLSVREFAEDRFFLFVTKRGMVKRSSASLYARARKGGLIAVGLRDDDELIMVREIHNDDHVVLTTGGGMAIRFACPDVRPMGRSATGVKGVALSGDDRVVACAVLPGDDtstEIMSISSNGYGKRTRIELYRLQSRGGKGVKNFRVTPKTGDVIGAMPVRDDEALVLLTSTNKIIRMSVDEVRSVGRATMGVMLVRLDEGAIVVGFDRV----DEREVVEESAPAQSSEQKTAPE----------
>UniRef50_C6XXU9(11-815:869) DNA gyrase, A subunit n=14 Tax=Bacteria RepID=C6XXU9_PEDHD   E=0 s/c=1.21 id=51% cov=91%
-----DKIIRIDIDEQMRSAYIDYSMSVIVSRALPDVRDGLKPVHRRVLYGMLDLGLANNKPYKKSARIVGEVLGKYHPHGDASVYNTMVRMAQEWSLRYLMVEGQGNYGSIDGDSPAAMRYTEARFQKIAEDMLADINKDTVDFQLNFDDSLQEPTVLPSKVPNLLINGSSGIAVGMATNMPPHNITETINATIAYIDNNEITIAELMKFIKAPDFPTGAIIYGYTGVQEAFETGRGRIVMRAKAEIE--AAKDREVIIVTEIPYQVNKAQMIERTAELVGEKKLEGISNIKDESNKDGIRIVYEIKRDANASIVLNNLFKQTALQTSFSVNNIALVKGRPQLLNLRDLIHYFVEHRHEVVVRRTKFELAEAKKRAHILEGLLIALDHLDEVIKLIRSSDTPEDARTGLMEK----------------------------------FGLSDIQARAILDMTLRRLTGLERDKIKDEYNELMKTIEYLQSILDDESKRMQIIKDELTEMKEKYGDERRTTIVHSAEDMSMEDFIEDEEVVITISHEGYIKRTPATEYRTQGRGGKGSKGSDSRNEDFIEHLLIASNHNYMLFFTETGRCFWLRVYEIPEGTRLSKGRAIQNIINIPKEEKIKAFIKVKnlkdqEYLENNYIIMCTKKGTIKKTSLEAYSRPRVNGINAININEGDQLLEASLTTGSSEIVMALRSGRAIRFNEEKVRPMGRTATGVRGVTLAhEKDEVVGMIAVDDpGATILVVSEKGYGKRTDIEDYRVTNRGGKGVKTINVTDKTGNLVAIKSVTDADDLMIINKSGIVIRIVVSELRVMGRATQGVRLINLKGNDEIASVARI------------------------------------
>UniRef50_C8PS29(12-838:838) DNA gyrase, A subunit n=1 Tax=Treponema vincentii ATCC 35580 RepID=C8PS29_9SPIO  E=0 s/c=1.17 id=47% cov=94%
-------LIPISIENEVKRAYIDYSMSVIVSRALPDVRDGLKPVHRRILYSMEEKNLRYSGPTRKCAKIVGDVLGSYHPHGDASVYDALVRLGQDFSLRYPVIHPQGNFGTIGGDPPAAYRYTEAKMARLAESMVEDIKKDTVDFIPNFDDSTQEPTVLPGKFPFLLANGSSGIAVGMATNMPPHNLREIAQAVSAYIDNPDITIDELAKYIKGPDFPTGGIIFGKKGIRQAFKTGRGKILVRGRFNIEVD-KKGKETIIFTEVPYQVNTTALVSKIGELAREKVIEGIAAVNDEtSDRAGLRLVIELKRGAIAKVVLNQLFSKTALQSSFGVINLALVGGRPQTLTLKQLVGYFVAHRQEVVTRRVRFDLKKAEERAHILRALIVAIDNIDEVIKIIRGSRDTASAKNALMER----------------------------------FSFDDVQAQAIVDMQLKRLTSLEIEDLRKELQELEVLIEHLKDLLAHPEKILALIKQETNELAEKFGDDRRTDIVsDEVEEINIEDLIKKEQMVVLVSNLGYIKRVPVTAYKRQNRGGKGSNSAALVEDDFIDQIFTASTHDYIMFITNEGKAYWVKVHEIPEASRTSRGSHIKSLLAVSSDEEITTIVSLKEFSSDTYLLMATAGGIVKKVQTDSFQNAKTRGIIAIKLDEGDKLVSAILTTGKDELMLVTRQGQALRVSEAEIRDQGRASHGVIGIRLSGGDELTGALRIN-NGKLLVMSENGYGKRVDFSEFSPHGRGTGGQKVYTVTEKTGEVVGLLAVADDDEIVCITGQGKTIRVQVSSINVMGRAAQGVRILDIESPDQLIGLDVVAREDEES------ITPAASETTFNGELDLDGGDAE-
>UniRef50_O84192(1-836:836) DNA gyrase subunit A n=16 Tax=Bacteria RepID=GYRA_CHLTR   E=0 s/c=1.15 id=47% cov=95%
MLNKEEIIVPKNLEEEMKESYLRYSMSVIISRALPDARDGLKPSQRRILYAMKQLNLTPGVKHRKCAKICGDTSGDYHPHGESVIYPTLVRMAQDWAMRYPLVDGQGNFGSIDGDPAAAMRYTEARLTHSAIFLLEDLDKDTVDMVPNYDETKYEPVVFPSKFPNLLCNGSSGIAVGMATNIPPHNLGELIEATLLVLANSQTSIEDILEVMPGPDFPTGGIICGTEGIRSTYYTGRGKLRLRARMHVEENSDKQRENIILTEMPYNVNKSRLIEQIAELINEKTLTGISDVRDESDKDGIRVVLELKKGESSEVVINRLYKFTDVQVTFGANMLALDKNLPRTMNIHRMISAWIRHRMDVIQRRTRYELNKAEARAHILEGFLKALSCMDEVVKTIRESSNKEHAKQQLVE----------------------------------LFSFSEAQALAILELRLYQLTGLEADKVQKEYSELLEKITYYRKVLAEEELVKDIIREELQELHKVHKTPRRTRIEMDAGDVrDIEDIISDESVIITISGDDYVKRMPVKVFREQKRGGQGVTGFDMKKGsDFLKAVYSASTKDYLLIFTNFGQCYWLKVWRLPEGERRAKGKPIINFLEgIRPGEQVAAVLNVKRFEQGEYLFLATKKGVVKKVSLDAFGSPRKKGIRALEIDDGDELIAArHIANDEEKVMLFTRLGMAVRFPHDKVRPMGRAARGVRGVSLKnEQDFVVSCQVVTEDQSVLVVCDNGFGKRSLVCDFRETNRGSVGVRSIVINQRNGDVLGAISVTDCDSILLMSAQGQAIRINMQDVRVMGRATQGVRLVNLREGDTLVAMEKLSINTESvETEENLAASVQSGQDTI-------------
>UniRef50_Q9RT53(4-811:812) DNA gyrase, subunit A n=2 Tax=Bacteria RepID=Q9RT53_DEIRA   E=0 s/c=1.16 id=50% cov=91%
-------IQPVDITSEVKTNFINYAMNVIVDRALPDVRDGMKPVQRRIMYAMLQEGLASNVKHAKSASVVGEVMKRYHPHGDSSIYDAMVRLGQWWNMRYTLVDPQGNFGSMDGDMAAAMRYTEARMTKVAEEILADLEKETVDLKPNYDETTTEPTVLPSAVPNLLINGASGIAVGMATNIPPHNLTEISNGLLALIDNPAITLDEMMTHVQGPDFPTGGRI-AKVGIREAYATGHAGLKVRGKARIE-EGKNGRTQIIISEIPYQLNKTNLLQTISAMYKAGKIPDIGALRDESDRkEPVRIVIELKRSAagMGTLVLNQLYKYTQLQSSYTVMNLSIVNGEPRVLPLIDTMRYFLDHRRDVVTRRTVYDLRKAKERAHVLEGLLKALDHIDEVISLIRASNTGAEARDGLMAR----------------------------------FGLSEIQAQAILDMRLQRLVGLEREKLQGEYDELQKTITRLESILGDEKLLWREIKKEIRDIRDRYGDARRSVITELEEDINKEDLIAVEDMVITMTRAGYVKRTNLTAYREQKRGGRGSSGGKLREEDANTGVFVGSTHDYLLFFTDQGRVFHEKIYDLPEAGRDAKGTHIRNLLPgLRDDENIASVLSVSGFDQPGSFIFATKSGVIKKSLITDYANITSAGLIAINLQPGDELIGVDIQQDGDDVVLATKNGQAMRFEATLVRDTGRATQGVIGIRLREGDEVVSMALVPGNDeegELLAISECGLGKRTKVSDYPSKGRGGLGVITLDVTDKTGKLVTLAHVAGNEELMVLTEKGTVIRTRVEEVRVTGRNAQGVKVINIGDKDRVID----------------------------------------
>UniRef50_C1TNA3(6-812:814) DNA gyrase subunit A n=1 Tax=Dethiosulfovibrio peptidovorans DSM 11002 RepID=C1TNA3_9BACT  E=0 s/c=1.15 id=46% cov=91%
---LFGKIIRHPLVEEIKRSYLDYAMSVIVGRALPDARDGLKPVQRRILFAMQELGLRHNQSYKKSARVVGETMGKYHPHGDSAIYDTMVRLAQNFSMRYTLVDGQGNFGSIDGDSAAAMRYTEARLQELGELMLQDIDEDTVEWGPNFDESLKEPMVLPSQVPNLLVNGSTGIAVGMATNMPPHNLGEVVDAICYLIEaGDQADFGELMARMPGPDFPTGGVILGKDGIIDAYRTGRGRLVVQGLVHVE-EGKRGKSNVVITEIPYMVNKTTMIETIASCVQNKTIDGVTDIRDESDRKGLRVVLEVSRDVDPDLVIRQLYRRSQLQNTFGVINLALVDGRPVELSLTDMLNVFLGHRRTVVRRRTEFRLKKAEARAHILEGLVKALDVIDRVIALIRGSDNAALAKERLVAE----------------------------------LDFSEIQAQAILDMKLQRLTGLERDKLNDEFAGLLADIQRYRSILDSEKVLDGVIVEELVALKGKYGDDRRTKIVDRvGQDCSDEDLIPREDIVVMLSRDGYLRRVPLEDYSLQAKGGKGRRGARLREEDEVSLMGVSTTHDDIFLFTTKGRVFAIKGYIISE-SRTGKGKLIGKYISLENDERVVSM-KTRRGQESGFLFFLTRRGIAKRLPSSELDNLTRAGRRVVTLDEGDEIAQILPTSGMDDLLLVSAMGQALRVSEDEFRPMGRSARGVKAMRLKDGDRIISGEVVTEDRRPILVSETGIGKRTNFEDFTVHHRGGGGMKVMSINSRTGLLAAATSVSEDDEIIVMTAKGRMIRVAAKEIRVLGRTAAGSIVVRLDGGDSVVDLSVV------------------------------------
>UniRef50_A7HL65(15-823:823) DNA gyrase, A subunit n=4 Tax=Thermotogaceae RepID=A7HL65_FERNB   E=0 s/c=1.07 id=46% cov=90%
------------LEDELVKSYLSYSMSVIIGRAIPDVRDGLKPVQRRIIYSMYELGLFHNKPFKKTARIVGEVMGKYHPHGDSSIYEALVRMAQPWLMRYSLVEGQGNFGSIDRDPPAAMRYTEARLHKIAEEMVEDIDKQTVKMLDNFDGSLQEPDVLPAKVPNLLLNGASGIAVGMATNIPTHNLNDVVDATIAYIKNRDISVEELIDIIKGPDFPTGGIIIGKSGIREMYITGKGGFTIRGKAEIKHEKK--KKSIIITEIPYGISKAELIKQIADYLQEEEIP-VKDLRDESDKDGLRVVIEFPEDVKEEVILNNLYQKTNLQTRFNANFLVIDgDKQPRLMNLKQLIEAYVKHRFEVVRKRTQYAYQQDSKRAHIVEGLIKASKAIDTVVSIIRSSKDSSEALSQLV----------------------------------DILQMSEEQAKAVLDMRLGRLTNLETQNLQQEYRDLLVRLEKEKELLMNDDKVYEVIIEELEEIKKKYGDPRKTEItdlEETATKFDKKDLIPNKDIVITLTKKGFLKLMDIDAFRTQRRNGKGVIGANLMEDDIISQIIYSKLHSKTLFFTSLGKVYEIENLDIEESNRGTKGKPINKYIKLENGERVLAMVDITDYVGE--LFFVTKKGVVKRTSLEDFKNITSKGIRAITFKDGDELVSVLRINSESNtVLISTKLGMSIRFGIEEVRTMGRNAAGVRGIRLREGDEVISSTVLeNDNGYILTITENGYGKLTEVSDYRKQSRDGLGIKNIGEIEKTGPIVGVAYVNGDEEIVLFTKDGASIKFKVSDIPTRSRTAQGVKVMNLADGDIVADFAVI------------------------------------
>UniRef50_A9NF72(12-833:857) DNA topoisomerase IV, subunit A n=1 Tax=Acholeplasma laidlawii PG-8A RepID=A9NF72_ACHLI  E=0 s/c=0.98 id=37% cov=93%
---IEEKIEKVLLEDIMSSRFGRYSKYIIQDRALPDARDGLKPVQRRILYAMGQMGLAFNKSYKKSARIAGEVMGKYHPHGDSSIYEAMVRMSQDFKMRVPLVDMHGNNGSIDGDSAAAMRYTEARLSKEAEFLLKDIDKRTVNFVPNFDDEEQEPTVLPARFPNLLVNGAMGISAGYATKIPPHNLNEVIDATIALIDNPNITNDEILKYIKGPDFPTGGIVQGKAGIKEALTTGSGKIIIRAKMNVEEMSKS-QDRIVITEIPYEVNKADLVRQIDNLRINNNIEDILEIRDETDQEGLRIAIDLKKGADAQFIQNYLLKSSDLQVNYNYNMVAILKHRPVLSGAFELLKVYLEHQKEVVTNRSNYELERATKRNHIVDGLIQMTSVVSEVIEEIRKSKNKADSKENIQKR----------------------------------FGFSELQAEAIVMLQLYRLSTTDIQALLDEKDTLYKEITRLEQILSNERILLKTIKSELQEVQTLLPSPRRTELEAEIEtiKIDEKDLISDEQTYVAITKDGYVKRASLRSVVASKEVG-------LKENDAMLYEEELNTLDTLLLFTNLGQYIYLPVYKIEEQKWRDLGVYINNIVPTSKGETIIRVLKVSDFSIDQKILLTTKQGQMKQVNLADFEVSRyNRPLRAMKLSKDDELVSVDY-NQLDNIVAISKHGYVLRFDTEELPVYGLTAGGVKSMALAEGDEVAVAFYAKESDDFYFLTSRGHIIKDTVLELPKYARNRRGIILVDRIKTSPHFiisasrVSKTQIKEDVKVRILSTKEALI-TTVSDLKYVA-NKYGKKMVEDGY-----YLEIYPAETEEKDTPVQPKKEVKKDDTLQAKV---------
>UniRef50_P73077(10-914:920) DNA topoisomerase 4 subunit A n=5 Tax=Bacteria RepID=PARC_SYNY3   E=0 s/c=0.88 id=36% cov=91%
------QIIPTDLHEEMERSYLEYAMSVIVGRALPDVRDGLKPVHRRILYAMYELGLTPDRPFRKCARVVGDVLGKYHPHGDQSVYDALVRMVQDFSSRYPLLAGHGNFGSVDNDPPAAMRYTETRLAPIAMgAMLEGISEAIVDFTGNFDNSQEEPTVVPAQLPLLLLNGCSGIAVGMATSIPPHNLGEVVDGLIGLINKPDLSDQELFKLIPGPDFPTGGHILDSEGILQAYQTGRGLIPVRGVSHIETirgekKRSHNRTAIVITELPFQVNKAAWIEKIASLVNDGKLDGISDLRDESDRTGMRVVIELKRDAEPNAILQKLYRMTPLQSNFGVIFLALVNNQPVQMSLRQILQEFLQFREDTLLRQYENELGENRRRLELLTGLLIGLENLDALIEILRFAADGTTAKIQLQER----------------------------------LGISLQQGDAILGMPMRRITGLEREKLQQEHTDLAQRIEQLETLIGDRQERLKALKKELRGLKKKFADERRTKIlqgmpakieplpvnqdplpeatippvesqsapeeeLDSPGEPEQEQLVlensspptadsapeakqddlnlavkptpktvkqeaqPSPEVIATHSKLVSVaEKNPLTLFTPQTPPAEAFLSINLQGEiawhpeeltsansfEPLDQQFSIQGRETLIVIGDHGKAFPVAIADIPPLAVTRI--PLLQILPKSAQRDATTVTfqgFLPPPEQPQDLLLVSQQGRVKLLAGQELQELGPRGLSLMKLKNGDLLQFAQLVtpvnpasaqNPGKNLVIATSNGRLLRFDPAQVGLTcsSPSAQGQEAMRLRATESLVGVLMASPGDRVLLLTQAGYGKQLDLASVRLGNFGELGTTVMQFTSKADRLLTMVAANQGAQspqsstYDFYSNQQRLHSVQADQFQPWGKDGFGDRLVDLNEGEHLIT----------------------------------------
>UniRef50_C1N3Z1(60-1081:1082) Predicted protein n=2 Tax=cellular organisms RepID=C1N3Z1_9CHLO   E=0 s/c=0.76 id=40% cov=92%
-----ERIIDTELSVEASQSYLAYAMSVIVGRALPDVRDGLKPVHRRILYAMHELGLDSKKPFKKCARVVGEVLGKFHPHGDQSVYDALVRMAQDFSMSAQLVDGHGNFGSLDADPPAAMRYTECRLRSVAEAMlLADIDADAVDFTETFDGSQNEPSVLPARLPNILINGSTGIAVGMATSIPPHNLREVADALAVYAADPDgCTLDDLLKVMPAPDFPTSGIIMAPkegKGFRDMYATGKGSVTLRGAAHIEEIKTSvrgknatTKNAVIITSIPYQarsihwspydrvgvvnaTNKASLCGQIADLVNSRQLDGVVDVRDESDRDGMRVVVEIRRSGDPNFVREQLYTRTRLQVRVSVNLVGLIGREPKVLTLMDIMREFLEFRCESIERRARHELSKASSRLHVVEGYLAVQAAPDAVVAAIRAAKDGPEAQKTLQEAP---------------------------------FSLSKEQSEAVLAMPLRRLTGLEHDKLRAEEADLTAKVEQLNALLSDRALVIAAVASEAKELRDKYGVERKTLIDHSAAKLAAEVAEARrrsppsgdggEDVgnvaeremaaaalyakrmnipldsldadnLIVMTGKGYIKRIDPKIFSRQNKGTIGKKGGRMRGGDQVTKVTHCNGLDTVLFFTDRGRVYAVRAYDIPQSSTTALGTPFTRVLKLAEGETITAMLPVDTASRrgsnvGEHLVMLTARGVVKKTPISEFANINRAGKRALGLQKGDRLKHVELVRDGDGIMVAGVDGMVLHFSMDSIRAQSRIGSGVKAMKFREasagatekkpkkppaahmlfaadaranapegtsynmaevskmwrelsDEEkapyevkaadlkekarrendaekksapaadgaaddgaadddddgdalpvlVAGMSIVPSDvvaafelatesdeagddddagtgdekpadecgAMVLLVTSEGQGKRISVGQFRQKGRGGLGNKAIGLEE--GSRLAAMCITGVDpalreagdaecvaeEVIIGSTAGVLNRYDVTELrPQLGRNAKGVKLMKLNDGDTVRDITLLP-----------------------------------
>UniRef50_A9F3U1(35-775:800) DNA gyrase subunit A n=3 Tax=Myxococcales RepID=A9F3U1_SORC5   E=0 s/c=0.99 id=37% cov=82%
---------DTSLADEAQRRYLNYALSVITSRALPDVRDGLKPVQRRILYAMlHDLHLGPDAKYRKSAAVVGDVMGKYHPHGDVAIYDAMVRLAQDFVMRAPLIAGHGNFGSVDGDAPAAMRYTEAKLRPLALELLSELGQRTVDFRPNYDGTRFEPIVLPSRFPNLLVNGSQGIAVGMATSIPPHNLGEVIDACVALIENRELTTHRLLSYVKGPDFPTGGQLHaTKKELEAVYTAGQGSLKLRGEWQLEEgDGKRGAApQIVITSIPYGIERKAIVEKIAEVILSKKLPTLVDVRDESTGE-VRIVMELKRGADAQLVMAYLYKQTPLAINVQVNLTCLVPtdnaeiAAPRRLGLHEILTKFLDFRYATVTRRLEFELGELRRRITILEGFEKIFDALDEVIRIIRKSEGKADAAEKLMKR----------------------------------FTLNEEQTDAILELKLYRLARLEILLVQKDLGEKRAEAKRIEGLLRSDAKRWGIVRDELVEIKGSYGEKRRTKVVGsiDEPEYQAEDFIVAEDANVILSAQGWVKRV---------REVKDLASTRIREGDSVLAAVAGSTRSTVAFFSNLGACYVCRIHDVPQS--TGYGDPVQKLFKLADGERLIALMSFDPraldvpaqtpdsaEPEPPFALAITRGGLGFRFSLRPHRDPSTRsGRRFAKLNEGDEVLFVHAVDGADRVLCASSDAWALSVAVEELALLSGPGKGSVVMRVAEGERLVGAALALGPSDVITVeTEKGKTLEIAASKIAGQ-RGTQG---------------------------------------------------------------------------------------------------------
>UniRef50_C4Z0V3(1-767:769) DNA gyrase subunit A n=29 Tax=Bacteria RepID=C4Z0V3_EUBE2   E=0 s/c=0.95 id=37% cov=85%
---MAEKIIRTEYSEVMQKSYIDYSMSVITARALPDVRDGLKPVQRRVLYAMDRLGLNYDKPHRKSARIVGDTMGKYHPHGDSSIYETLVVLSQDFKKGMALVDGHGNFGSIEGDGAAAMRYTEAKLKKFTQDVyLADLDKNVVDFVPNFDETEKEPEVLPVRVPNLLVNGADGIAVGMTTNIPPHNLSEVVDAVCAYMDNEDITTDELMQLCPGPDFPTGGIVINKSELGAIYETGTGKIKLRGKVIFEPaKNRSEKDKLVITEIPYtmiGANIGKFISDVVSLIETKKTTDIVDISNESSKEGIRIVLELKKNADVKNLENLLYKKTKLEDTFGVNMLAIVDGRPETLGIKDIIKHHINFQYELATRKYTTLLEKEKANREIKEGLIRACDIIDLIIEILRGSANLKMAKDCLVNGNVEGIKFKSEQSKKQAAG----------------LDFTERQAGAILEMRLYKLIGLEILNLQKEYDECVKKIEKYEKILGSRKEMAKVIKADLLNIKKEYGVERRTVIEDGEAAVFEEKKIPEMEVMFIMDRFGYARTIDMAAFERNKDAVFNEN----------KYVIPVMNTDKICIFTDTGDLHQLKIKDLPFTKFRDKGTPIDNLCNYDSSKEIIVYITPFERLKNQKMLFVTRQGMMKLVDSEEFQVAKRT-VACTKLADDDKLIGMystdarveiyskfsldgeikeeEVVESNQNVIVQTENGVFLKFPLTDIPMKKKSAVGVRGIKLSKDDYIEDVFLLTEGDE---FTMEYKGKSISFAKMKTAHRDTKGTK-------------------------------------------------------------------------------------------------------
>UniRef50_B3PLT5(9-791:949) Topoiosmerase IV subunit A n=1 Tax=Mycoplasma arthritidis 158L3-1 RepID=B3PLT5_MYCA5  E=0 s/c=0.92 id=33% cov=84%
MYNLTETIIEKNMVDVMSERFGRYSKYIIQQRAIPDARDGLKPVQRRILYSMYGLKLYNNQAFRKSAKIVGEVMGRYHPHGDSSIYEALVRMSQEWKSNFPLIEMHGNKGSIDDDPAAAMRYTESRLEKISELILKDLDRKVVAMAPNFDDTEYEPVVLPSLIPNLLINGSKGIAAGFATEIPPHNLSEVIDATIKLIKNPLISLEELKQIVQGPDFPTGGVIHGIEGIAQAFETGQGKINISSRYRFVYAENKPSKIigIEIYETPFGVIKSKLVADIDFLVIDKTINGVKEVRDQSNREGISIYLELEDEANAEAIINYLMSKTDLRISYNYNMVAIHENSPKLMNLQMLLFTYLSHLKDINTKGIEFDLKKYEIRLEIVQGFIKVSEISDEVIRVIKNSDNSK---------------------------------KGVIEALEKTFGFTNIQATAIAELRLYKLSKMDQLEFQNEAKELAIKIARCKELLENPNEFDKFIIEQLKDIKKEYAKPRFSEISQDKirTEINTKLLAKNEDFYFFLSKEGYIKRISKKAFSSN-----GFSGFKLKDNDAIFYYDKINSLSKLIFFTNLGNYFIIDAHTLKENGWKDIGNHISSLVALENNERIIRVMEIESFNTYSRFIILTKKGMAKKVEIQEFDSKQiARKRSCIPLRPNDELCDVRIVNKEKLLFILLTGGLYYLIDENVVPEYSLKASGISLIKTDRDQEIEAFSPISPKNKVIIMTDKGQFKRTKMETVKLVGRSSHG---------------------------------------------------------------------------------------------------------
>UniRef50_C3CV72(4-739:740) DNA topoisomerase n=1 Tax=Bacillus thuringiensis Bt407 RepID=C3CV72_BACTU  E=0 s/c=0.96 id=41% cov=84%
------KIETISYSKEMKSSFIDYALTVVTDRALPDVRDGLKPVHRRILYAMGDLGMYPDKAYKKSARIVGEVIGKYHPHGDSAVYESMVKQAQDFVKNAPLIDGHGNFGSVDGDSAAAMRYTEARLSPVAMEMIQDLSKGVVDFRDNFDASEREPVVLPAKVPNLLVNGGVGIAVGMAYKTPPHGVNSVVDTLIAYADKQDIDIESLIDIIEAPDYPSGGIITNKNELRDLYRTGIGKAVIRAKIDIE-DAGYGRKNLVVKEIPYPYsgSKTNLTYKLITMVIEKKLEEIVNVTDESDKDGIRIVLEVKKGVDIDNLLNKLYSKTPLQSSESYQYLVLVNGVPTTINLKDYCKHYFDFQKEITRKRYEYLLSKAQVRKEILEGLVKAEEMMDTIIEMLRGAKKSKEAKVCLMEGNTESISFKTK----------------KHENIAKKFAFTEKQAQAILDMRLQKLIGLEVEQLNQEYKEVLAEMEEYELVLGSEKEMLKVIKKYLRGFKKDFGRERRTEIQEKKT-IEYVEEIKEEDVWVLIDKFGYTKSVDTISVERSSEETLS----------EYKQEILTKNTSKLSVFTNQGRLYQIKLADIPKVKIKDKGVPIQRLGKMKKNEYPLYITTNTELETER-VIMLTKTGLIKQTLCSELISSRSV-VVATKLEEDDEVIQITPINEvDEDVLVFSKKGYILRFSINEIPVLRKNAKGVKAVSLMEEDVIEGVYILNENNKDV---KQLNGKQIELSKVERKTRGKKGI--------------------------------------------------------------------------------------------------------
>UniRef50_Q83G39(19-795:824) DNA gyrase subunit A-like protein n=2 Tax=Tropheryma whipplei RepID=Q83G39_TROWT  E=0 s/c=0.91 id=36% cov=83%
-----EKITDVDLLHQMQDSFLEYAYSVIHSRALPDARDGLKPVQRRILYTMSRMGLSPDKAHVKCARVTGEVMGKLHPHGDAAIYDTLVRMSQDFTMRIPLIDGHGNFGSL-NDGPAASRYTEARLSRAAVAMINDLESNVVDFVPNYDNQFTQPEVLPALLPNLIVNGSSGIAVGMATSIPPHNLQETVRAAIYLVRNRQSSLEQIMKILPGPDFPTGSIIVGKEAFKEIYATGKGSFKIRAKISIDY-AGIGHTNLVITELPYMVGSERVIEKIKQGVNAHRIDGILDVTDLSDRkNGLKLVIGIKPNFSPNEVMDNLYRHTPLEESFSVNSVALIDGKPKTLGMLDMLKVFIDHRVCVITRRSKFYLATHKKRLHMIDGLLLALVDIDKTISIIRNSEGIKEARKNLMK----------------------------------CLNVTRDQAEYILDIRLNMLTKLSTIKLQSEQEELRKTTQDLEEILSDPNKIDAILIDELKKVAQRLPSPRRTILESSVKSKKQKTDYPRQ---VVLTTNGFIFTIEVNNDLISELSQPETFDMAFNTHseplRVVKSSIVCGVRSRIGALTSAGKVIPFTPIGLPVLDSGF--VTAKSFLGLENDEEAVLLF---ELHQKESLAIATSSGIVKRVTPAIWPDRTER---VITLSAGDRVVGAARgVSSCGYFVFITAKGNLLHYSAGLVNPQNRPARGVAGVTLKdDDDRVISFGYTEDVDraNVLTVSKRMTTSR--LSSYQTRGRATRGVQCHKFLK-------------------------------------------------------------------------------------------------
>UniRef50_C6XHT3(13-752:753) DNA topoisomerase IV subunit A n=27 Tax=Alphaproteobacteria RepID=C6XHT3_LIBAP  E=0 s/c=0.89 id=40% cov=76%
---VEENVKAVSLRFALEERYLAYALSTIKERAIPDLRDGFKPVHRRIIHAMSEMGLDFGAAFKKSARIVGEVIGKLHPHGDQSVYDSLVRLAQPFVQRYPLISGQGNFGNIDGDSAAAYRYTEARMTQVAELILQGVDEDAVDFRDTYNEEDSEPVVFPSKFPNLLANGTSGIAVGMATSIPSHNVQEICEAALALIDNPEISIEKLLEYIIGPDFPTGGIIVeSRESIVESYRLGRGGFRVRARWCVE-EVGRGSWCIVVTEIPYQVQKSRLIEKIAELIIAKRIPLLEDIRDESA-EDVRIVLFPKnRSLDPDLLMESIFMLSDMETRFPLNMNVLSMGRvPQVMPLDGILKEWLAHRREVLFRRSSFRMQAIDRRVEILKGLLIAYLNIDEIIAIIRNEDKPK-------------------------------------PVMVSRFSLTENQVDAILNLRLRSLRKLEEYQIKSELDNLLAEKEKIDSLLNSGKQQWNQIACEIREVKEIFSKstdlgRRRTtfcEVSRADKATLQQAMIEKEPITVVISNRGWIRSL--------KSHSVDLSALHFKEGDSLKIALHAHTTDRILLLSTDGKAYTLPAGNL--LSGRGHGEAIQLLIDLNHNQDIVTAFV---YDSTCKLLVVSSKGNAFIVEESEIIANTRKGKTFLKVSSEEKMKLVVKVTG-DHVAVVGENRKLLIFSIDQIPEMSR-GKGVR---------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_P43702(7-729:747) DNA topoisomerase 4 subunit A n=115 Tax=Bacteria RepID=PARC_HAEIN   E=0 s/c=0.90 id=36% cov=76%
-------IEQMPLRTFTEKAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNATAKYKKSARTVGDVLGKFHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDpKSFAAMRYTESRLSKISEILLNELGQGTVDYQPNFDGTLAEPQYLPARLPHILLNGTTGIAVGMATDIPPHNINEIADAAVMLLDNPKAGLDDVLEIVQGPDFPTEAEIISpKSEIRKIYEQGRGSIKMRATWKKEDGE------IIISALPHQSSPSKVIAQIAEQMTAKKLPMLEDIRDEADHEnPIRIVLVPRSNrVDTDALMAHLFATTDLEKSYRVNMNMIgLDHKPAVKGLLEILNEWLDFRRTTVTRRLQYRLDKVLSRLHILEGLMIAFLNIDEVIEIIRHEDDP---KAELMAR----------------------------------FNLSDEQADAILNLRLRHLAKLEENQLKAEQDELEKERLNLEAILGSERRLNTLIKKEIQEDAKKYANPRMSQLVEREEAkmISESDMTPAEPVTVILSEMGWV--------RCAKGHDIDPKSLSYKAGDSYLAHACGKSNQAVVFIDSTGRSYALDPLSLPSA--RSQGEPLTGKLNLPTGATIEYVVMASEQQE---LLMASDAGYGFICKFEDLIARNKAGKALISLPENAKVLKPKtLINSTALVVAITSAGRMLIFPAQDLPVLSK-GKGNKMIT------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q57532(12-1245:1273) Mle gyrA intein n=207 Tax=cellular organisms RepID=GYRA_MYCLE   E=1e-180 s/c=0.51 id=40% cov=92%
-----QRVEPVDIQQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMLDSGFRPDRSHAKSARSVAETMGNYHPHGDASIYDTLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYcvsgnslvrllfgksirigdivTGAQFNSdnpidlkvldrhgnpvVADYLFHsgEHQTYTVRTTEGYEitGTSNHPllcLVNVGGIPTLLWKLIGEIRSGdyvVLQRIPPvefgpadwystmeallfgafisggfvfqdHagfnsldrdyftmvvNAYDTVVGGLRCISSRitvsgstllELDVYNLIEFKKTrlsglcgqrsadklvPDWLWHSPSTVKRAFLQALFEGEGfsSILSRNIIEISYSTLSERlaadvqqmllefgvvserychtvneYKVVIanraqvemffTQVGFGVTKqAKLIRDVvsmspcvgmdincvpglatfirkhcdnrwveEDSFNQHNVDCVQHWHHHSaeivghiADPDIRaIVTDLTDGrfyyaRVASVTDTGIQPVFSLHVdtedhSFLTNGFISHNTEARLTPLaMEMLREideetvdfisnydgrvqepmvlpsrfpnllangsggiavgmatnipphnlyeladavfwclenhdadeetmlvavmervkgpdfptaglivgsqgiadayktgrgsirirgvveveedsrgrtslvitelpyqvnhdnfitsiaeqvrtgrlagisnvedqgsdrvgvrivieikrdavakvvlnnlykhtqlqtsfganmlsivdgvprtlrldqmicyYVEHQLDVIVRRTTYRLRKANERAHILRGLVKALDALDEVITLIRASQTVDIARVGVVE----------------------------------LLDIDDIQAQAILDMQLRRLAALERQRIIDDLAKIEVEIADLGDILAKPERRRGIIRNELTEIAEKYGDDRRTRIIAVDGDVNDEDLIAREEVVVTITETGYAKRTKTDLYRSQKRGGKGVQGAGLKQDDIVRHFFVCSTHDWILFFTTQGRVYRAKAYELPEASRTARGQHVANLLAFQPEERIAQVIQIRSYEDAPYLVLATRAGLVKKSKLTDFDSNRSGGIVAINLRDNDELVGAVLCAADGDLLLVSANGQSIRFSATDeaLRPMGRATSGVQGMRFNADDRLLSLNVVREDTYLLVATSGGYAKRTSIEEYPMQGRGGKGVLTVMYDRRRGSLVGAIVVDEDSELYAITSGGGVIRTTARQVRQAGRQTKGVRLMNLGEGDTLLAIARNAEE---------------------------------
>UniRef50_B9SK06(108-501:540) DNA gyrase subunit A, chloroplast/mitochondrial, putative n=5 Tax=Magnoliophyta RepID=B9SK06_RICCO  E=1e-165 s/c=1.48 id=57% cov=45%
------RVVHTELHKEATEAYMAYAMSVLLGRALPDVRDGLKPVHRRILFAMHELGLSSRKPFKKCARVVGEVLGKFHPHGDSAVYDALVRMAQDFSLRSPLIQGHGNFGSIDADPPAAMRYTECRLEALTEAvLLADLELDTVDFVPNFDDSQKEPSLLPARLPTLLLNGSSGIAVGMATNIPPHNLGELVDVLCALIHNPEATLQELLEYMPGPDFPTGGLIMGNLGILEAYRTGRGRIIVRGKTEVESlDSKTKRTAVIIKEIPYQTNKASLVEKIAELVENKNLDGVSDIRDESDRSGMRIVIEVKRGSDPSIVLNNLYRLTPLQSSFSCNMVGILDGQPKQMGLKDLLQASY-FRCSVVERRARFKLLQAQERRHIVEGIVIGLDNLDGVIRIIK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A7ANB1(657-1120:1437) DNA topoisomerase 2 n=3 Tax=Piroplasmida RepID=A7ANB1_BABBO   E=1e-112 s/c=0.88 id=23% cov=48%
-----------------------------TERSIPSVVDGWKPGQRKVLFGCLKRNLV---GECKVAQLTGYVAehSAYH-HGEASLQQTIINMAQNFvgSNNINVLEPCGQFGSRkeGGKDASAARYIFTKLNPITRLIFVEEDDNILEYQ-NEEGQTIEPMYYIPTIPMVLVNGSEGIGTGFSSQIPNYNPLDIIDNLKRYLNNVDMK----------PMVPWYHKFTG-----EIEPNDKGGFDCLGNYQWLDENGL----LEITELPIRKWTHDYrvfLESLEQGVN-GKEPLILGFVDNSTHESVHFTLNVNPECIEEVINEGVDKVFKLRTSIATTNMTLFDANKKlkrYSNELEIIRDFAAVRLATYEKRKTYLINNLKLLLRRISNQVRFIHMV-----VNEELVLFKKAKATLVAELRDLGFDSNTDILKGSEEPSTLNEPVTPSRRSGTQDAPGADYNYLLNMPLWSLTLEQVQKLNEEHAQ-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D0NA12(738-1220:1505) DNA topoisomerase 2 n=1 Tax=Phytophthora infestans T30-4 RepID=D0NA12_PHYIN  E=1e-112 s/c=0.84 id=25% cov=48%
-------------------------------RSIPSVMDGFKPSQRKVLFCCFKRNLRA---ELKVAQLAGYVSehSAYH-HGEASLQGCIVNMAQDFvgSNNIHLLSPIGQFGTRlmGGKDAASARYIFTNLEQLTRLIYHPLDNDCLKYL-SEDGQSIEPEWYIPIIPMVLVNGSDGIGTGWSSSVPNYNPLDIIKGLRQMINGEEIAP--LTPWYRG---FTGHIV----EKANSRGTDTGNYIVQGLYEV-----TDDSTLVVSELPVKSWTQTYKQFLEGLLDAGT---IKDFKENHTDVKVLFTITMEPKALSDVTKApgGIVKKFKLESSLSTSNMHLFDaagHIKKYENPKEIMAEFYGIRLEYYGRRKKAMLQKLQDQIKLLSNKARFVLAVVEG-KLVVNNRKKQELLEELMAEGYDQIVSKTKKKPDNEDSNESEDEEPNVADVSRG-------YDYLLSMKIWSLTKERVDKLRAELQE-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A6DRS7(37-660:808) DNA topoisomerase IV subunit A n=1 Tax=Lentisphaera araneosa HTCC2155 RepID=A6DRS7_9BACT  E=1e-110 s/c=0.65 id=30% cov=51%
----------------MTGNFIDYASYVIKDRAIPDVDDGLKPVQRRILHTLFK---ADDGKFHKVANIVGACM-AYHPHGDSSIYGALVTVA----NKEYFIEKQGNFGNIlTGDNASAARYIECRLSPLARETL--FNTETTEFVDSYDGRNKEPVCLPAKVPALLMMGTEGIAVGMATRILPHNFNELLKAQIKILRGQRFEIY--------PDFLCGGIMDISQ-----YDFGRGKVTVRAKIDI-----LNNKTLVIKQVAPGTTTESLMSSIEEAAKNGKIK-IASIQDYTAEH-VEIEINLPRGVQADWALNALYAFTQCEVSLSPNITVIQRGRPKEIHVGEVLHHNTQTLVNILRWELLNEQNKLNEKYH------------DRTLERI-------FIEERIYKKIEECTSQSEVFEAVRSGLKPFLDQLRR--------DVSDEDIERLLRIPIRRISLFDINKNNKE---LEEILKALKEVAYNLEHLKDYTINFIKNLISKYGKqyPRLTEI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q6PUA3(654-1134:1662) DNA topoisomerase 2 n=4 Tax=Tetrahymena thermophila RepID=Q6PUA3_TETTH  E=1e-110 s/c=0.83 id=21% cov=49%
------------------------------ARSIPSLCDGLKPGQRKILFACFKRNL---KNEIKVAQLSGYVAehSAYH-HGEQSLESTIVGMAQSFvgTNNINYLMPIGQFGSRnmGGKEAASARYIHTCLNKITRCVFPEPDDHILYYLED-EGQQVEPIYYLPIIPTALLNGADGIGTGWSTSIPCYNPRELVDSIEKRMMGVPFT--DLLPWYKG---FTG----------EISNNEKSQITVSGKYHL-----VNETTIEITELPIKKWIRDYKNFLEEKLEstKDKDPEIEDIKEYHAGNRVHFVVKMSEKQMEKVQREGIDKYFKLQSTIPTTNMVLFNHEGKltrYANICEIMEEFYEVRLNAYKRRKEYLVSKIERDLEILSNKKRFILAvINESIRV--RNAKRKDLIKELSVQGYVQMKDMPKIKSSKLTSQLEQEQNQDSNEENFETNPNEinaKEYNYLLSLPMWSLTYEKVEEIKQEQKNKQDELDKL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D2UZM0(692-1170:1457) DNA topoisomerase II n=1 Tax=Naegleria gruberi RepID=D2UZM0_NAEGR   E=1e-107 s/c=0.82 id=24% cov=48%
-------------------------------RSIPSIVDGLKPGQRKILFSCFKRNL---KKEIKVAQLAGYVSeqSAYH-HGEDSLNGTVVNMAQNFvgSNNINLLYPGGMFGTRlqGGKDSASPRYIFTKLSEITRYIFPKADDPVLEYLDD-DGQSIEPRFYVPILPMVLVNGSEGIGTAWSTNIETYNPVDIVEGLKALIKGEEA-----------------------KEFHPWYKGFDGIIERLAPTKWQTKGvieKIDDNTLDISELPIRIWTESFKERLEKMMEAQQVD---DFRENHTDVTVSFTVKMTDKQMKDAEDAGLYDYFKLFKKFSTSNMVLFseeGGIKEYETVLDILKEFYPIRLKFYGKRKEYMLEKMKKELEILSNKVRFImEVINETIQV--KKRKKADLLKELKTKKYSSFPKEKKIAAAGDI--QNEEEEEEEDEEKDVADLTDG-YNYLLSMPLWSLTVEKVKKLEKEKEEKVKEVEQLE--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_P06786(667-1156:1428) DNA topoisomerase 2 n=27 Tax=Fungi/Metazoa group RepID=TOP2_YEAST   E=1e-106 s/c=0.79 id=22% cov=50%
-------------------------------RSIPNVLDGFKPGQRKVLYGCFKKNL---KSELKVAQLAPYVSEctAYH-HGEQSLAQTIIGLAQNFvgSNNIYLLLPNGAFGTRatGGKDAAAARYIYTELNKLTRKIFHPADDPLYKYIQ-EDEKTVEPEWYLPILPMILVNGAEGIGTGWSTYIPPFNPLEIIKNIRHLMNDEE--LEQMHPWFRG----WTGTIEEIEPL---------RYRMYGRIE-----QIGDNVLEITELPARTWTSTIKEYLLLGLsgNDKIKPWIKDMEEQHDDN-IKFIITLSPEEMAKTRKIGFYERFKLISPISLMNMVAFDphgKIKKYNSVNEILSEFYYVRLEYYQKRKDHMSERLQWEVEKYSFQVKFIKMIIEKEltvtnkprnAIIQELENLGFPRFNKEGKPYYGSPNDEIAEQINDVKGATSDEEDEESSHEDTENVINgpeelyGTYEYLLGMRIWSLTKERYQKLLKQKQEKETELENLLKL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q6U961(103-549:555) Topoisomerase II medium subunit n=3 Tax=unclassified T4-like viruses RepID=Q6U961_9CAUD  E=1e-87 s/c=0.73 id=24% cov=49%
LSNHLTELHNRSLQSIINHEALEFAMYTVEERAIPSLIDGLKPVQRFFMYRALEYAKQNRSKFNKVAALAGGVSEAgYH-HGEGSAAGAGQLIANTWNNNIPILEGDGNFGSRMVQQAAAPRYVFCRVHQNFWDIYRDIELAPVHPEP----EHLPPRYYLPVIPMVLANGVKGIATGYATNIFPHSYKSLIKCTKAAIEGKPIPRLE----VQFPEFS--GVIRRVSAK---------TIEVEGLYEL-----SGQTKLTITELPVKFDRLSYVILLDKLKDQGK---IVSYKEQH-KNGFRFDVTLKRqdkfgeqlQNNPEATHEKIIKMFGLRQVLTQNITVLNpEGKLaEYECAEDVIRDFVEHRRKFTAERVEYERQKSEHARDLAWAKFKFINMvIDDKITIkgKQKAELVKEIASNPDFKGFENELVGMSIYRMTEDETYKLQDEAIKQGKLFDYWLgTTPEAEYINDL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q6WHM1(2-413:428) Topoisomerase II small subunit n=1 Tax=Vibrio phage KVP40 RepID=Q6WHM1_BPKV4  E=3e-77 s/c=0.71 id=28% cov=37%
---------------------LEYAMYTIENRALANGIDGLKPVQRFVLYNVIK---DASTSFDKVAALGSSVSKIGYNHGETSAQDALALMAAEWQNNVPIVQGRGNFGSRMVKESASARYVYAKLHDNFDLYFKDIHLSP----EHKDLEHVPPQFYVPVLPMILMNGVQGIATGFACNILPHDPEWVKKAVLEYLAGKEISE----PVVKFPEF--YGKIEKLE--HNKYAQ-IGTVEISGL------------TAVVTEIPTGFDHAKYIIELDKLVEKGKISSYVDETSETFQFRVRF----KRG--AKMTEESVIKTLKLQSTFTQNINVIDENyqIRHFDDVRELVKWFVDFRMSFLPKRIQDSTERTEKRA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q4EDX9(7-334:334) DNA topoisomerase IV, A subunit n=2 Tax=Listeria monocytogenes RepID=Q4EDX9_LISMO  E=2e-63 s/c=0.75 id=28% cov=34%
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EIKIDTEVLVANEDVIVSVTKEGYVKRTSQRSYAASNGAE-----LAMKEADHAIFIQKMNSLDSLLLFTSKGNFIYRPVHELPDIRWKNLGDHVSHLAsDLSAGEEIRSAIAIQAFTEEKRFLFVTKNGMTKQSAITNYKPQRySKSMMAIKLKGDDELLNVHLIDGTEDIFLATKNGYGLRYSITEIPESGARTAGVKAINLKQDDIVIGGIVlmPNEQKHILLATQRGSLKQMKASEFEPISRAKRGLLMLRELKSNPHrFIGITLADNNDHLFIETNTDQIVEIDVANLRITDRYSNGSFVLD-------------------------------------------------
>UniRef50_B1QFR9(1-196:241) DNA gyrase, A subunit n=2 Tax=Clostridium RepID=B1QFR9_CLOBO   E=2e-57 s/c=1.16 id=41% cov=23%
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MCTRNGIIKKTEISKYSSIRKGGLNAINLREDDELIDVKMTKGNDEIIVVTQNGYCIRFNEEDVRPMGRVATGVKAITLRKTDKAVSMDVVIEDETLLSISENGFGKRTDIEEYPIHRRGGKGVITYKITDKTGPIVGARFVKEDDELMLVNSGDVAIRINVSEISKTSRNAMGVKLMRTSEEEKIVAIAKIKSED--------------------------------
>UniRef50_C2WAD0(1-184:193) Topoisomerase IV subunit A n=3 Tax=Bacillus cereus group RepID=C2WAD0_BACCE  E=2e-32 s/c=0.78 id=26% cov=21%
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MIKKTELNQYKVQRySRAFVAVNLKKDDEVVDIFVTDGTSDIVLATHGAYALIFGEEEVSPVGIRAAGVKAINLKEDDYVASGKPLNGEkDQLILVTQRGAVKRLKASEIEKSTRAKRGLVIFKELKRNPYrIVGIEIVRDDELVYMKTEKQIVEEIDPKMFRNKDRYSNGSLVLDVTDTGEVV-----------------------------------------
>UniRef50_C9KLW4(1-804:808) DNA gyrase, A subunit n=1 Tax=Mitsuokella multacida DSM 20544 RepID=C9KLW4_9FIRM  E=0 s/c=1.28 id=55% cov=91%
------KIVPVNLEHEMKNSYIDYAMSVIVARALPDVRDGLKPVHRRILYAMQEAGMGSNKPYKKSARIVGEVLGKYHPHGDSSVYDAIVRMAQDFSMRYMLADGHGNFGSVDGDPAAAMRYTEVRMSKIAELMLQDIDKETVDFTPNYDESLKEPEVLPAKFPQLLVNGTSGIAVGMATNIPPHNMCEVIDGTLMLIDHPDATIDDLMKVIKGPDFPTAGLILGQDGIRQAYTTGRGVIKMRANARIET-LSNGKPRIIVTELPYQVNKARLVEKIAQLVRDKQIEGITALNDESDRGGMRIVIDLRRDANANVILNQLYKHTQLQDSFGVIMLALVDGKPKILNLKEVLHYYIAHQEDVITRRTRYDLKKAEARAHILEGLTIALDHLDAVITTIRESRTADIARAALI----------------------------------SGFKLSEKQAQAILDLRLQRLTGLEREKIEEEYQEVLKAIEEYKAILADEGRILAIIKDELKAVKAKFGDARRTRLTVDTSEIDVEDLIAEEDVVITLTHNNYIKRMALDTYRRQNRGGKGIKGMPTKEKDFVENLLITTTHHTILFFTNRGRVYHLKAYEIAEASRAAKGTAIINLLQLEKDEKITAVIQVKGFNPDAYLFMATKKGIVKKTSLVEFKNLHKGGLNAINLDDDDELIGVKFTDGERDMILGTKWGMAIVFGEDDVRAMGRAARGVKGISLNDGDEVIGMDTLSPNAEVLTVTAEGYGKRTETSEYRAQNRGGKGLINLKVTEKTGDVIGLRVVHPDQELMLITTEGIVIRTNISDISVISRNTQGVKLMSTGENDIVASMAV-------------------------------------
>UniRef50_A9GW54(4-871:873) DNA gyrase subunit A n=2 Tax=Proteobacteria RepID=A9GW54_SORC5   E=0 s/c=1.18 id=49% cov=99%
-----QQKVPVSIQDELRTSYLDYAMSVIIGRAIPDVRDGLKPVHRRILYSMNEQKIGPTGAHKKCARVVGDVLGKYHPHGDLAVYDALVRMGQTFSLRYPLIDGQGNYGSVDGDSPAAMRYTESRLSRMAVELLADLDKDTVDFVPNYDDSELEPSVLPAKFPQLLVNGSGGIAVGMATNIPPHNLGEIIDATIAIIRNPDVTLEELLHLVPGPDFPTGGLIYGKSGIVQAYTTGRGSITMRGRSQVEKTMKGDREQLVFTEIPYQVNKARLVAKIAECMKEKRIEGISEVRDESDREGMRIVVELKKDIFPQVVLNQLYRLTDLQATFGVINLSIANGRPAVLSLKDTLSHFIEHRREVVTRRCRFELRQAESQRELVEGLGMATSDIDRIVATIRASSDPDDARENLQKLPLRGLGEFLRRAGRPEPECAEAD-------TRGDYFLSERQAKAILEMRLSRLTGLEREKLAKEYGELSQTIERLRAILADMGLLMNVIVMELEEIKARFGDKRRTEIVPAEAEIQMEDLIQEEDMVVTISHAGYLKRTPTSTYRAQRRGGKGMVGMEAREEDWVSQLFVASTHSYVFFFSDKGKVFVKKVYEIPQAPRNAKGRAIVNFVGMEPGEKVAAITPVPSFDGETFVVTLTRRGQIKKTALNEYENYRDKGIIGVRIEEGDQLFTAALTDGKRELVIATRSGMSIRFPEDQVRPTGRATMGVKGIELDEGDVVVGLGVSgDGRDRVLAVCERGYGKQTPLEEFRLQSRGGKGVILIDASERNGPVVGVAMVSPSDEVLIVTDRGQMIRTKTSEIRETGRNAQGVRIMHVGQDERVVAVEAFAADAAEAEDGGSTPPSAgvDGTNGVADHAGGNGSSE--
>UniRef50_Q2IHQ4(27-885:907) DNA gyrase subunit A n=15 Tax=cellular organisms RepID=Q2IHQ4_ANADE   E=0 s/c=1.18 id=54% cov=94%
---------QVNIEQEMRKSYLDYSMSVIIGRALPDVRDGLKPVHRRVLYAMHTEGLHYNKRYSKCAGVVGEVLKKYHPHGDASVYDALVRLAQDWNLRYPLIDGQGNFGSVDGDPAAAYRYTECRLERLSDHLLADIDKDTVDWGPNFDESILEPRVLPTRFPNLLVNGSAGIAVGMATNIPPHNMGEVIDAAVHLIENPKATVLDLMRFIPGPDFPTAGIIRGRDGIRAAYEKGRGTIQVRARTVVEIHPKTERETIVVTEIPYQVNKAKLVEHIAELVREKRIEGISDLRDESSREGMRIVIELKRDALAQVVLNNLYAHTQMQMGFGVIMLAIDGGQPRVLTLKEMLERFVAHRRDVVTRRTRYELRKAREREHILLGYQIALDHIDEIIELIKKAKDRDAARDEMMAR----------------------------------FALSELQAKAILEMQLQRLTGLERQKILDELAEVQKLITRLKEILASEKVLMELIVGELREVKQLFADERRTEIQGEATDLSTEDLIAEEEMVVTVSHLGYVKRNPVSLYRAQKRGGRGKTGAATRDEDFLESLFVASTHSYLLVFSDKGKVYWLKVHEIPPAGRTAKGKPIVNLVQLAPGEKVAAILPVRRLPepagaaeetpeaegaeaekaeeataegPPAFVFMVTRKGLIKKTRLEQFARPRAAGIIGLGIEEGDELITARLTDGGGHILLSTARGMAIRFEESDVRPMGRTAYGVKGITLEEGDEVVAGAAIPAAAegeqahTVLTVTANGYGKRTELAEYRVQTRGGKGLITIKTTERNGPVVAAAPVGDAEEVMLITNAGMLIRMPARGISVIGRNTQGVRLITLEsKEEQVVGVARVAETTPEAEEAGV-------REEPEGAAPVETAPQDE
>UniRef50_C7MEZ8(68-917:943) DNA gyrase subunit A n=21 Tax=Actinobacteridae RepID=C7MEZ8_BRAFD   E=0 s/c=1.13 id=44% cov=95%
-----DRITQIDLNHEMQRSYLDYAMSVIVSRALPDVRDGLKPVHRRIVYAMFDGGYRPDRSFSKCAKVVGEVMGNYHPHGDSAIYDAMVRLVQPWSMRYPLILGQGNFGSAGDDGAAAPRYTECKMAPLALELVRDIEQDTVDMQGNYDNTVDEPTVLPARFPNLLVNGSAGIAVGMATNIPPHNLREVADAVQWLLKNHEATKPELLEAclqrIKGPDFPSGATIVGTSGIEDAYRTGRGSITQRAVVSTEEI--NGRMSLVVTELPYQVNPDTLARKIAEMVKLGKIQGIADITDEtSGRTGQRLVITLKRDAVAKVVLNNLYKHTQLQENFSANMLALANGVPRTLSIDSFVREWTKHQIDVIVRRTKFRLRKAEEQIHIFRGYLKALDALDEVIALIRRSPDVDEARTGLM----------------------------------DLLEIDEIQANAILAMQLRRLAALERQKIIEEHDRLQALIEEYTAILADPQRQRDIVSEELAEIVDRFGDDRRTEILPFAGDMEMEDLIPEEDMVVTITRGGYVKRTREDQYRAQKRGGKGVRGASLREDDVVEHFFTTTTHRWLLFFTNQGRVYRAKGYELPEAPRDAKGQHVANLMAFQPDENIASVLAIDSYEDAQHLVLATESGLVKKTPMPAFDSSRTGGIIAINLRDidgpegpqPDRVISARAVNSDDEILLVSRNGQSVRFPADDgtLRPTGRATSGVTGMKFRHQDTLLAMDVIRPDSFVITVTDGGFAKRTTVDEYRLQGRGGLGIRVAKLPDDRGHLVGAAVVEETDELLVVMERGRVVRSKVAEVPAKGRTTMGVVFAKPDKGDRILLVTTgqesEVDEEEAEAPEIIDADPAGSEDAV--ENSADAAPEG-
>UniRef50_C5JAM2(6-884:890) DNA gyrase subunit A n=1 Tax=uncultured bacterium RepID=C5JAM2_9BACT  E=0 s/c=1.09 id=48% cov=95%
---LFDDIKRIPLEEEMKQSYLDYAMSVIVARALPDVRDGFKTVHRRILYVLKRLGFDHTKPHRKSALIVGEVMGKYHPHGDSAIYETMVRMAQDFSMSIPLIDGQGNFGSIDGDSAAAMRYTESRMAKISKEILADLDCNTVAFRPNYDGSLQEPTVLPTRVPSMLLNGTSGIAVGMATNIPPHNLGELLDACCALVENPLMELPEIMEFVKGPDFPTGGQILGTSGILNAFRTGRGSIVMRGKASVE-ELKGDKEAIVVTEIPYQVNKAKLVEKIGELSRDKVVDGIGEIRDESNRHGIRIVIEIKRDGNSQVILNQLYKHTQLQMNFSANVLALVKGVPQTLGLKASLTCFLEFRYDVIVRRTRYFLEKARDKAHILLGFALALSHIDQVITLIKAATDRKSALATLMHENWDAASIKSYLAL----------LQGPQAESGPYYRLSEIQANAILDLRLHKLTGMEQEEIKSDLQSTMDAIQEYIDILGKPERVRKIMTDEFKTIKADYPTPRRSEILPAEDDIEDEDLIPSEEMVVTISFGGYIKRVPLSTYRAQLRGGKGRSGMTMKEEDYVQDIIVANTHDRLLFFTNIGQVYRIPVHQLPIGTPQAKGRAIINVLPIEKDEKITSILDVsKEMDDASTLLFITSKGQVRRNAVSDFERIQSNGKRAMVLEDGETLIAVKTCRNDNTVLLNTRKGLFIRFDATDVRVfSGRTSTGVRGIKLAHDDTIISASVLEGfnvdpaeralylraraaergiqgetedqdttvegalsderllelqehEQYILTITDLGFGKRTSGYEYRTTGRGGLGANGILLSAKNGHVVNAFPVIPQDQIMLITNKGRLLRCGVNDIRIAGRRTQGVILMRLEKDERVVNVTRIEETEE-------------------------------
>UniRef50_Q9ZLD9(5-821:828) DNA gyrase subunit A n=50 Tax=Campylobacterales RepID=GYRA_HELPJ   E=0 s/c=1.15 id=49% cov=92%
----TKNIVEVGIDSSIEESYLAYSMSVIIGRALPDARDGLKPVHRRILYAMHELGLTSKVAYKKSARIVGDVIGKYHPHGDTAVYDALVRMAQDFSMRLELVDGQGNFGSIDGDNAAAMRYTEARMTKASEEILRDIDKDTIDFVPNYDDTLKEPDILPSRLPNLLVNGANGIAVGMATSIPPHRIDEIIDALAHVLGNPNAELDKILEFVKGPDFPTGGIIYGKAGIVEAYKTGRGRVKVRAKVHVE--KTKNKEIIVLGEMPFQTNKAKLVEQISDLAREKQIEGISEVRDESDREGIRVVIELKRDAMSEIVLNHLYKLTTMETTFSIILLAIYNKEPKIFTLLELLRLFLNHRKTIIIRRTIFELEKAKARAHILEGYLIALDNIDEIVRLIKTSPSPEAAKNALIER----------------------------------FSLSEIQSKAILEMRLQRLTGLERDKIKEEYQNLLELIDDLNGILKSEDRLNEVVKTELLEVKEQFSSPRRTEIQESYESIDTEDLIANEPMVVSMSYKGYVKRVDLKAYERQNRGGKGKLSGSTYEDDFIENFFVANTHDILLFITNKGQLYHLKVYKIPEASRIAMGKAIVNLISLAPNEKIMATLSTKDFSDERSLAFFTKNGVVKRTNLSEFGGNRSySGIRAIVLDEGDELVGAKVVDKNaKHLLIASYLGMFIKFPLEDVREIGRTTRGVMGIRLNENDFVVGAVVISDDSNkLLSVSENGLGKQTLAEAYREQSRGGKGVIGMKLTQKTGNLVSVISVDDENLnLMILTASAKMIRVSIKDIRETGRNASGVKLINTA--DKVVYVNSCPKEEEPENLET-------------------------
>UniRef50_A6DH72(1-853:859) DNA gyrase subunit A n=1 Tax=Lentisphaera araneosa HTCC2155 RepID=A6DH72_9BACT  E=0 s/c=1.10 id=47% cov=95%
-------VTPQGIEKLLSDAYLQYSMSVNVGRAIPDVRDGLKPGMRRVLFAMDKLNLRKGSSYMKCARVVGDVIGKYHPHGDGSVYDTMVRMAQDFSMRGMLIDGQGNFGSIDGDSAAAYRYTECRMERLAEELLTDLDKNTVDMQPTFDGSQNEPTVLPARYPNLLVNGTTGIGVGMATSIPPHNLGEVINATVALLDQPSITIEEMMQHLPGPDFPTAGISIGFDGIRRLYETGRGGVHLRGRAEIIE--KNGREQIVITEIPYAVNKENMVKKIAELVNNKVITGISSLNDEsSSRVGIRVVVGIKTNAMATVVINQLYKHTQLAVSIGCQFLVVDNKQPKTLNLKQLLQAYLDHRLEVITRRIKFELEKAERRAHILEGLLKAVDHIDEVIKIIRASTNREDAHNQLKER----------------------------------FELSNEQAKAILDMRLSQLTGLAIDELTAEYEELMKRIAHYRELLANRQMRLDVVKEELIEVRDKFADERRTEMRPGERDINYEDLIARASATITISNEGYIKRVPTEIYRTQNRGGKGVKGMETKDDDFVKQLTTACTHDYIMFFTNFGRMHWLKVYDIPEATRVSKGKAMVNLLEFEKGEYVRAMISVDKvDDEDRFIMMSTRNGVVKKTALAAFKNMRKKPIKAIVLDEDDDLIEAKLTDGNKKIILSTREGIACHFKESDCRTQGRVTRGCRGIRLSESDQVVAMSIVEESEDILVVTAKGMGKRSCVDDYRLTKRGAKGVRNIKLKEG-DYVVEVMMIEDTDEIIMTTMEGLMVRISAEPIRSLGRASQGVTIMKFKKaSDLIISASRVVEVEADKdeeneegedSENAESANTEEGSEAPAESAEQAEESSDE
>UniRef50_P47719(18-843:846) DNA gyrase subunit A n=26 Tax=Bacteria RepID=GYRA_MYCGA   E=0 s/c=1.13 id=47% cov=94%
-------VKEASITKELETSFMEYAMSVIVSRALPESRDGLKPVHRRVLYGAYTSGLTHDKPYRKSAQIVGHVMGKYHPHSDSAIYETMVRMAQPFSLRYMLIDGHGNFGSIDGDSAAAMRYTEARLSKISAEMLRNIDKDTVDFVDNYDASEQEPIVLPSLFPNLLANGSSGIAVGMATNIPPHNLSELIGGIKHLLVNENATIEELKEFIKGPDFPTAAEILGETGINEYFNTGRGSVSVRAKSEIE-ELANNKSNIVITQIPYMVNKANLINKIAELVKTEQIQGIADLRDESNREGIRIVIETKRDVIPEVLLNQLYKSTQLQTNFSVAMLALVNNQPKVLNLKEALQIYIDHQFDILLRKTNFELKKAKASAHIVEGLVIATNNIDDVIETIKNAKDNEDAKNTLMTK----------------------------------YELSDLQAKAILDMRLRSLSGLERENLQKELAKLKELIKDLEEILQNKERRIKIISDQLDEIDHKFGDERRTKICYGlNSTIDNEQLIPVETVVITRSSKGYLKRIPISAYKVQHRGGVGVKGMNTYEDDDVESLIVCSTHSDLLFFTNYGKVYRIRAHQVPLGSRISKGIPAINLISIEKDEKLMSLLSINDYDSG-YFFFSTKKGLVKRVKASEFSRIQNNGKIAIKLTENDSLFKVIKTAGDEEIYIGVSSGLLVRFKEDVVRSMGRTAQGVIGVKFKnPNDEVIGLSSSHEGSLLLAVCEKGVGKMTDREEYRMTNRGSKGVITIKVTPKTGNIINTQLVNGNEELLMISSTGKIVRVPLAEVSEQGRNTSGVKLISLNEKETLQSVAIFDVEQDD--------SQQVGSDNPDTELSSDDSNQDQ
>UniRef50_Q1UZ45(10-849:849) DNA gyrase subunit A n=2 Tax=Candidatus Pelagibacter ubique RepID=Q1UZ45_PELUB  E=0 s/c=1.09 id=46% cov=94%
-----KNIKLISMHDEMSSSYLSYAMSVIVSRALPDVRDGLKPVHRRILFAMYKGGYDWSKQFRKSARIVGDVIGKYHPHGDQSVYDALVRMVQDFSMSLPLVQGQGNFGSIDGDPAAAMRYTETRLAKVSQYLIDDIEKDTIEYKSNYDETEKEPSVLPAQYPNLLVNGAGGIAVGMATSIPPHNLGEIIDGTLALIENKDIKIKELMKHIPGPDFPTGGVIIGKEIIKAGYNVGRGSFKIRGEISVEAQ-KNGRERLVITSVPYQVNKSVLNERIAQLVREKKIEGIKDIRDESNREGIRVAIDLRNGVEPETIKRLLYKNTSIESSFGFNTLAIVDGKPKICDLKEFLTNFLTFREDVVIKKTKFDLKKAEDRAHILIGLSVSVENLDKIIKIIRSSKTPDDAKKSLLNTKWKINKSLKLISLVEDKKEK------------NLYSLSDPQVIAILELRLQKLTALGINEIEVEIKKLADLIKGYKKIINSKKELLNVISEELKTIKEKFAVPRRTKIIDAILNYDIEETIQKESVIITVTLQGYIKRGALSSVKQQKRGGKGKSGITTRDEDSVVQTLSVNTHTSVLFFSTEGLVYKIKAWKIPEGSTTSKGKSLFNILPLKNHQSISSIMPFPDEESDTKnlqIVFATAKGKVRKNSLEDFSSINSAGKIAIKLDPNDKIVGVEICKDDQDVMLSTKNGKCIRFESKKLRIfKGRSSKGIKGIELSPNDEIVSLSITNkekikkdtksDGRFVLSITENGYGKKTLNNEYRVTNRGGKGIIGIVNSPRNGSICSSFPVIEGDDVMISTNKGRVIRVAVKEIRTAGRNTQGVRIIKLSGDEKVVSAIKI------------------------------------
>UniRef50_Q45066(4-805:806) DNA topoisomerase 4 subunit A n=136 Tax=Firmicutes RepID=PARC_BACSU   E=0 s/c=1.10 id=41% cov=90%
---------DLPLEEVIGDRFGRYSKYIIQDRALPDARDGLKPVQRRILYAMHTDGNTFDKNFRKAAKTVGNVIGNYHPHGDSSVYEAMVRMSQDWKVRNVLIEMHGNNGSIDGDPPAAMRYTEARLSPIASELLRDIDKNTVEFVPNFDDTSKEPVVLPAMFPNLLVNGSTGISAGYATDIPPHHLGEVIDAVIKRIQMPSCSVDELMEVIKGPDFPTGGIIQGVDGIRKAYETGKGKIIIRGKAEIETI-RGGREQIVITEIPFEVNKANLVKKMDEFRIDKKVEGISEVRDETDRTGLRVVIELKKEADAKGILNFLYKNTDLQITYNFNMVAIHNRRPMLMSLPSILDAYIGHQKEVVTNRSVYELQKAKDRHHIVEGLMKALSILDEVIATIRSSSDKRDAKNNLIAK----------------------------------YEFTEPQAEAIVSLQLYRLTNTDITALKEEAEELGKKIEELESILSNDKKLLKVITNSLKALKKKYADTRRSviEEKIEEIKINLEVMVASEDVYVTVTKDGYLKRTSQRSFAASNGQDFG-----MKDTDRMLHQFEMNTTDVLLLFTNKGSYIYCPVHQLPDIRWKDMGQHFSNLITIDRDETIVKAIPIKEFDPSAYLLFFTKNGMVKKTELTHYKAQRySKALVALNLKGEDELIDVHVTNGESQIFMATHLGYGLWFGEDEVNVVGARAAGVKGINLKEDDFVVSGEILQQSDSIVLFTQRGAVKRMSLSEFEKTSRAKRGVVMLRELKKNPHrVVALFACGLEQRLMAETEKGDRKELQTKELRTNDRYSNGSFFFDEEESGKVTAVWRL------------------------------------
>UniRef50_UPI00016C558B(23-769:883) DNA gyrase subunit A n=1 Tax=Gemmata obscuriglobus UQM 2246 RepID=UPI00016C558B  E=0 s/c=1.16 id=46% cov=85%
-------INPLDIVDELRDSYLTYAQSVIISRALPDVRDGLKPSQRRILVAMNDLGLGPASSTSKCAGIIGETMKRYHPHGDASIYDSLVRMAQDWNLRYRLVHGQGNFGSIAGLPPAAHRYTEARLTPAAGELLEDLERDTVDFIDNYDGKYREPLVLPGKFPNLLVNGSDGIAVGMATHIPPHNLREVCKALVLLLDNPGATLADLIQIIPGPDFPTGGIIMGRQGLLEAYARGAGKITLRARAQVMEEVKGRSPSILISEVPFQVTRNAIVEEIAHLVKEERIPDVSGVRDESSArngEPVRLIVEIKRGKDPHLVLNQLYQYTKLQKTVSIIMLALVDGRPRELTLKEMLQKFLDHRVHVIRRRTEFLLREAKKRGHVLEGQLIAIADIEQVIQICRTSPNRAEAKARLQGLAVPAALMQRAI------GEGAFAALQRELGAVAEYRMTEQQAEAVVNLRLGQLAALESEEILKEYLQLRELIRGYETLLSDDANIHAVIREDLERMAAKYGDDRKTEVSDDGGDVDMEDLIVDEPNVVTISHEGFVKRMALTEYRVQGRGGK-GVQGGLRDNDFVEHFFVASTKAYLLCFANTGRMYWLKVYRIPTAGRTSPGRAIANVLSLAEGEKISSIVPVREFVEGAHLLMATRQGTVKKTDLMAYSNVRQGGIIGITLDEGDELINVALTRANDEVVLSTQKGMAIRFRESAIRPMGRTARGVRGIKLGKDDALVGMVVADPDGLLLTVCENGYGKRTPF---------------------------------------------------------------------------------------------------------------------
>UniRef50_A4S991(32-895:897) Predicted protein n=1 Tax=Ostreococcus lucimarinus CCE9901 RepID=A4S991_OSTLU  E=0 s/c=0.94 id=40% cov=88%
-----EKIIDVELASEAKTSYLSYAMSVIVGRALPDARDGLKPVHRRILYGMHELGLRADKPHRKCARVVGDVLGKYHPHGDGSVYEALVRLAQDFSMSAPLVDGHGNFGSLDDDPPAAMRYTECRLNKLAEKgLLADIGNECVNFTETFDGSQTEPEVLPARVPNLLINGSSGIAVAVATNMAPHNLGESVDALCALAKNPDCSLDELMALLPAPDFPTGGVVTNKSGMKEIYETGKGGVTLRGRATIERvsaaRGSLDKDAVVISEIPYQTNKARLVEQIADHVNGRTIDGISDIRDESDRDGMRVVIEIKRGYDAASVLEELYAKTKLEVKFFVNNVALIDNKPTVMPLRQILDEFIKFRVDTIERRTRFMLSKAQDRKHLVEGFSIVLADADGVVKIIRKSKDGPSASKKLRESH----------------------------------GLSDIQADSILAMPLRRLTGLEADKLDAELKELNEQIAHFQGLLSNKSKVIDVLVQEAMEAKEAFARPRRTSVEQIESLSGVEDDSPPKDNILTLSERGYVKRICPKNFGAQNRGTRGKRMSKLRANDELSKAMHCKDSDQILFFSDRGRVQKLSAKAIPQSELNTIGVPATSLLNTfaKRNQNVTAMLSTNmkqgEVADDQVVVMLTSQG--KVSVASAASMLGHKGKKVITLDKGDRLQQVMFARTSDHLFITGTgkagKGLILHCRVGDFRVVKSACRPISGIKTMGEKKVaeavvedagddedddeddgellppktVGMAIVPGErmvsaseefgPFILFTTKKGKGKVVAANSYRLLGRGRSGVMCMKFKKGDDDALATITLVDrigddvTDEVLLSTTGGISNRIAVNDLP--------------------------------------------------------------
>UniRef50_Q98RX7(59-874:877) DNA gyrase A-subunit n=2 Tax=Cryptophyta RepID=Q98RX7_GUITH   E=0 s/c=0.97 id=37% cov=91%
------RIINTELQNEMAKSYMEYALSVIYGRALPDIRDGLKPVHRRILFAMYELNLVPEAPYRKCARVVGEVLGKYHPHGDTAVYDSLVRMSQEFSMRKVLILGHGNFGSIDHDPPAAMRYTECKLSNLSVDtLLKELDFKTVEYVYNFDGSSIEPSIMPSVIPSILLNGSSGIAVGMATSIPPHNLGEIVRSCLALIDNYNITNQELIKYLPCPDFPTGGLIIGNNSCKDLYEKGISSIILRGKINVEFSksvKKVSKYNLIITEIPFQINKSMLIAKLADLVNSKIIQGISDIRDESDRKGIRIVIEIKRDYDPIKIVKIILKKSSLQITFSSYMLCIVDKQPILVNLKEILSLFLHFRRKIIRKNIKFELKNILKKKNILKGISISLEKIDLTIEKIKKSINNLEAKCILME-----------------------------------FGLSQEQSEAILNLQLRRLTKLESKKIDNDFEITKSSLNELKCILSSNILIDGIIKNQIKNISEIYGFPRKTLLINSINENIIEELetIENYESVIMITQ-YYIKKMFLESFESQTRGTKGKRGLIISDGDEISHFFSCNNRDDLIAISSGGIAYKIKVSRIPISKRNSKGTPILSILKGLENNQISSIIATSNCETEKFLVLLTQKGLIKRTSISNFNNISSRGLIILTLDENDSLKWVRKCYNDDSVIISTKKGKLLRFNASqkELKSTGRTSKGIKSIDLDSNDIISDFDIIPSQaitNFIILLTEMGYGKRIKVTELKIQKRGKKGIKVISLRENvNDYLISSRFCIENEEILISTSYGNVVKQKISDIAVQKKNSKGIIIQRLTEGDKVSKISII------------------------------------
>UniRef50_Q1D9G9(56-787:813) Type II DNA topoisomerase, A subunit n=3 Tax=Myxococcales RepID=Q1D9G9_MYXXD  E=0 s/c=1.04 id=38% cov=82%
--------VPASLADEARRRYINYALSVITSRALPDVRDGLKPVQRRILFGMFhDHRLTHEAKYQKSAKVVGSVMGQYHPHGDASIYEALVRMAQDFSLRYPLVDGHGNFGSLDGDGAAAMRYTECRLAMLSSELLTELGKKTVAFRPTYDGTLQEPVVIPARVPQLLMNGTTGIAVGMATNIPPHHLGELVDALVALIENPQLLTKDLLKWVKGPDFPTGGQILNdKKELRDIYESGQGSIRIRGEYKLE-DLKRGGQQIVITSIPYTVNKSTLVAKFGDLVRERKLPLITDVRDESTKD-VRIVLELKKDANPELVMAYLYKQTPLQTNFGVNLTCLVPikdkpelSTPERLNLRDILWYFLTFRFDVVTKRFEHELGELLRRVHILEGFEKVYDALDEMIKIIRASEGKQDAARKLIAR----------------------------------FKLDEAQVDAILEMKLYKLARLEILVVEKELKEKRAEIKRIQGILKDKNKVWGTVRDELGEMKARYNDKRRTRIggaGSEEMEFSAEAFIADEDAHVVITRDGWVKRV---------REVKDPSTTRLREGDAVMAVLAGSLKANLVLFSNFGTAYVTRFNDVPAS--TGYGEPVQKFFKFDDGERVVSALSLDaRLPRPQKLVGVTKQGMGMRFLLEpHLEVSTRAGRRYAKTGEGDEIIGVQPVTDRDLLAVLTEKTSALVCKVAEVNELAGPGKGVTVIKVDGGDRVVDFLAVSPaqkDAKLEFETQKGRKLHLSPAKYEVTGRGGKG---------------------------------------------------------------------------------------------------------
>UniRef50_Q7UU73(25-813:825) DNA gyrase subunit A n=1 Tax=Rhodopirellula baltica RepID=Q7UU73_RHOBA  E=0 s/c=0.94 id=38% cov=85%
-ESLLAEIQNIPLRFAAQDRYLNYSLSVITSRALPDVRDGLKPVQRRVLYTMSLLRLDSSAKHSKCAKVVGDVMGKYHPHGDSSIYEALVRMSQSFSLRMPMIDGSGNFGSIDGDNAAAMRYTECRMTPIASEVLADLSSRTVAFKPNYDGTREEPVVLPSRVPSLLVNGATGIAVGMATNIPPHNLKEVCNALLKLLANPEIKDYQLVagDAIQGPDFPTGGHITNtKEELREIYATGTGTIKLRGVAEVAEKSRTG-DTLRITEIPFGVNKAAMVERIAELVYSSKLPLVQEVRDLST-EDIRVDLLLKKNADADKVLAYLYKHTPLQTNFNVNLTCLTPtenpevGAPKRLGLKEILWYFLHFRLDVLTARLTNELRALEKRIHILEGLALIFDALDEIIKIIRSSEGKADAAEKIMKRFPVKELTPAQARRKTRASN----------------GLDAEQTDAILELKLYRLARLEINVVLDELKKKRKRVDEINKLLADDRDdytssgRWAIIKEELQSLISDYGNTpagrRRSTIVvpTEEVEYTEEDFIVAEDCHVMVTVDGWVKRQK---------QIADPSKSRLRQGDAVLACVAGNTRTTLAFFSSLGVCYTARMIDIPAS--TGFGEPIQKLFKFKDGERIIAALSMDprilgdisedpkgNYYPATHALAASTDGYALRFGLQPFAEPSTRaGRKFARVKPGASIVDVVPIAGTETVLAVSADARAMVCPADEINYLSGAGKGVLLLKLAASDKLLGFKPSTGDRDLLnVVTNRGAKKTVSTAKYRTTSRGGRGI--------------------------------------------------------------------------------------------------------
>UniRef50_C5SLW9(8-738:738) DNA topoisomerase IV, A subunit n=1 Tax=Asticcacaulis excentricus CB 48 RepID=C5SLW9_9CAUL  E=0 s/c=0.95 id=42% cov=76%
------RILSEPMGEALSRRYLAYALSTIMHRALPDVRDGLKPVHRRVLYAMHNMRLNPQAAARKSAKVVGEVMGNFHPHGDQSIYDALVRMAQWFAQRYPMVDGQGNFGNIDGDSAAAMRYTECKMTTAAMLLLDGIDENAVDFRPTYDGQDEEPVVLPAAFPNLLANGATGIAVGMATSIPPHNVAELIDACKLLIAEPNTDTNGLMAIIPGPDFPTGGIcVERREAIYEAYETGRGSVRVRARYEVE-DLGRGAWRILVSEIPYQVQKSRLIEQLADLIEAKKAPLLGDVRDESDEE-VRLILEPKtRNIDPEVLMESLFKISDLETRFAFNMNVLDKtGTPRVMGLKTILTSFLDHRREVLIRQSQWRLDKIEKRLHVLDGLMIAFLNLDEVIRIIREDETP---KQTLMAR----------------------------------FELTEVQVDYILDTRLRQLARLEEMAIKGEHDKLSKERDGLLSLLGSEKKQWKRIDEQLTEVRKQLLSARRTTFAEAPQGVEvaaIESYLPKEALTVILSERGWIRAT--------KGRVDDPSELKFKEGDNLGFLVPGYNTDKLLIMTSDGRFFTLGCDKLPSG--RGHGEPLQLMLEMEENTRIVNVFM---FTPGAKRLMVSKNGYGFVMNEEDAVGNKKAGKSVLN-ADGTEAFVALPVTG-DHVVILGENNKVLVYPVSELPEMAR-GKGVK---------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q59749(13-701:758) DNA topoisomerase 4 subunit A n=64 Tax=Alphaproteobacteria RepID=PARC_RHIME  E=0 s/c=1.00 id=38% cov=77%
-----DNIQPVDLKAALEERYLAYALSTIMHRALPDVRDGLKPVHRRIIHAMSEMGLRPNSSFKKCARIVGDVIGKFHPHGDQSVYDALVRLAQDFSQRYPVVDGQGNFGNIDGDNAAAYRYTEAKMTEVAALLLEGIDQDAVDFRPTYNEEDQEPTVLPGAFPNLLANGASGIAVGMATSIPPHNAHELCDAALHLIKHPDATVEDLLfdpanpqrGGIEGPDFPTGGVIVeSRASMAESYRTGRGGFRVRARWAVE-DLGRGGFQIVVTEIPYQVQKSRLIEKIAELLIARKLPLLEDIRDESA-EDVRVVLVPKsRSVDANILMESLFKLTELESRIPLNMNVLSMGRvPRVMALNEVLSEWLAHRREVLQRRSRHRLAAIDRRLEILGGYLIAYLNIDEVIRIIREEDEPKAV-------------------------------------MIERFGLTDVQAEAILNMRLRSLRKLEEFEIRTEFDSLSKEKAEIEALLASGDKQWQAVAWEIGEVKKKFAKatelgKRRSTFSDAPDadvEAIQQAMIEKEPITVVISEKGWIRAL--------KGHIADTSSLQFKDGDGLKVSFPAQTTDKILIFTTGGKAYTLGGDKLPGG--RGHGEPLRIMVDMENDQDVLTAFV---HDPARKLIVSSTAGNGFVVTESDIVANTRKGKQVMNVTMPDEAKLVVPVKG-DHLAVVGENRKMLVFPLVQVPEMAR-GKGVRLQRYKDG--------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_O54478(17-703:759) DNA topoisomerase 4 subunit A n=18 Tax=Alphaproteobacteria RepID=PARC_CAUCR  E=0 s/c=0.98 id=40% cov=76%
------RILDEPLTEALSRRYLAYALSTIGSRALPDVRDGLKPVHRRVLYAMSNMRLNPDAAARKCAKVVGEVMGNFHPHGDASIYDALVRLAQEFSQRIPLVEGQGNFGNIDGDSAAAMRYTECKMTEAAMLLLDGIDEDAVDFRPTYDGQDEEPVVLPSGFPNLLANGSSGIAVGMATSIPPHNAAELIDACQLLLANPDATTADLLEKVPGPDFPTGGVIVeSRASLLETYETGRGGVRMRAKWEKE-DTGRGTYQIVVTEIPYQVKKSDLVEQLADLIDSKKAALLGDVRDESA-EDIRLVLEPKsKNVEPEVLMESLFKLSALESRFPVNINVLDaRGTPGVMGIKQALMAFLAHRREVLTRRARHRLAKIEARLHILDGLLIAYLNLDEVIRIVRYEDKPKE-------------------------------------KLIETFGLTDIQADAILNTRLRQLAKLEEMEIRREHAELVEERDGILAMLASEAKQWKLvgvglseVRAALLKIKHPLDKPRPTGVTGRsvfgeapqvDADAAIEAMIVREPITIILSERGWI--------RAAKGKIDDPSELKFKEGDKLGFLVPAETTDKLLIFSSDGRFFTLGCDKLPSA--RGHGEPVRMMIELDDKVKIIDVFP---FKAGRKRILASKGGYGFLMPEEEALANRKAGKQVLNV--GNEGAAFCLEAVGDQLAVIGDNGKILIFPLEELPEMPR-GKGVK---------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C5J6X2(1-731:864) Topoisomerase IV subunit A n=1 Tax=Mycoplasma conjunctivae HRC/581 RepID=C5J6X2_MYCCR  E=0 s/c=0.92 id=36% cov=79%
MKTNLNQIINSSLDNIVAEKFIRYAKYVIQNRAIPDVRDGLKPVQRRILYSMWMLGLKKEKAYKKSARVVGDVIGKYHPHGDSSIYDALVRMSQEWKINIPLVDMHGNKGSIDDDPAAAMRYTEVRLEEISALMLELLNKNVISWAPNFDDSEKEPTVLPTIVPNLLVNGAIGIASGFATEIPPHNLSEVIDGAIAMIKNEKITNSELQSIIPGPDFPTGGIVYDNGGISDAFSKGKGRISLVAKYEIV--NKNKDISIQISQIPYGIAKANLIRQIDDIRFEEKVYGIKEVIDQSDRNGILISIDLEADANVDLVVNYLLQKTDMQIYYSYNSVAICNNSPKLVSLSEMIKYYLDHLKNIKLKEIDYDLFKSQKRYEIIQGFLKVADITDEVIKVIRASDNSK---------------------------------IGVIKDLIAHFGFTQIQAEAIAQMRLYRLSKIDQENFLSESKELENKIELLNNLKNDSTAFKKFLIKTLKQVQNNFGQPRKTQILkkDFSIKINHEDLIKDENIYFGITQQGYYKKISLKNFSLS-----DLDKYAIKKDDFLILLTKLNLKDKIFLVTNKANLVVLAAHQLEETSYKNIGNDLKIEVDFQQDEYIVAQINISENKNNSNIILVSKHGLAKRVSLDSLFNLRTKKLTNIfKLKEHDELIGAYLTDNLANIAIISNLNRSLKVAEIDIPIYGRNSAGVKLATLKKGEQI-----------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C9RLW5(18-681:846) DNA topoisomerase (ATP-hydrolyzing) n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RLW5_FIBSS  E=1e-116 s/c=0.64 id=30% cov=51%
--------------------FLDYASYVILDRAVPYFEDGLKPVQRRILHSMFE---NHDGRYQKVATIVGRTM-AYHPHGDASIGDALVGLGQK----NLLIDTQGNWGNPyTGDRAAAPRYIEGRLTPFAVDVV--FNPETTEWIPSYDGRSEEPVTLPVKFPLLLAQGVDGIAVGLSTSILPHNFRELCEASIACLRGKKFTLY--------PDFFTGGIIDVSD-----YNDGQrgGKVKVRAKIE-----KVDNKTLAIREIPYGTTTVSLIESIVKANDKGKIK-IKHVDDNTSQ-GVEILVHLQPGTDPQVAIDALYAFTDCEKSLSPCTCVIIDKHPKFVGVSDILKLNTEHTVKLLEWELANELKHLEDKWHMTTLEKIFIEK--EVYEVIKKAKDREQII-RLVREGLTP-----------------------YLKRLHRQTVTDEEIGKLIEIPIRRISHYDREKADQLLQELEENIAKCK---YNQEHIIDYAVNHFKNILKKYgeGKERRTQI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D1QVZ0(119-745:978) DNA topoisomerase 4 subunit A n=2 Tax=Prevotella RepID=D1QVZ0_9BACT   E=1e-115 s/c=0.67 id=27% cov=58%
--------------------FLDYASYVILERAVPHIEDGLKPVQRRILHSMKRM---DDGRYNKVANIVGHTM-QFHPHGDASIGDALVQMGQKD----LLIDCQGNWGNIlTGDRAAAPRYIEARLSKFALDVV--FNPKTTDWQLSYDGRNKEPITLPVKFPLLLAQGAEGIAVGLSSKLLPHNLNEICDAAIKYLRGEDFQLY--------PDFPTGGAIDVSK-----YNDGQrgGVLKVRAKIE-----KLDNKTLVIREIPFSKTTTTLIDSILKAIDKGKIKA-KRVDDNTAAE-VEIQVHLAPGVSSDKTMDALYAFSDCEINISPNCCVIEDNKPCFLTVSDVLRHGVDRTMGLLRKELQIR------RGELLEQLFFA-------------SLERIFIEQRIYKEK------KFEQAADMNEAVAFVDLKLTPFKPDFIREVTRDDILRLMEIKMQRILKFNKDKADELIARIKAEVAEIEHDL---EHMTDVTINWFMFIKNKYGNehPRHTEIRSFDTIDSAK--------VVEANQKLYINRQ------------EGFIGTGLKKDEFVCN---CSDIDDIIIFYKNGKYKIIKVAD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_UPI00016B2480(1-417:417) DNA gyrase subunit A n=1 Tax=candidate division TM7 single-cell isolate TM7c RepID=UPI00016B2480  E=1e-114 s/c=1.00 id=37% cov=46%
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------FGLSEIQAKAILAMQLRRLTGLEREAIENELRELLALIEKLKGILADEQEILNIIKNELIEMKEKYGDQRRSKmINHELGKFSDEELIPEEDSVVLLTSENYIKRTLASDYRKQNRGGKGKRGMTTKETDVIEHMIPAGTHDWLLFFTNRGRVFRLKAYEVPAASLQAKGVAAVNLLQLQPEEKITAIIKFEKDaKDDGYLFMATVKGTIKKTPVKDYANIRTNGLIAIKLDDGDELRWIKRSSGNDDILISTSAGQAIRFNEKDARSMGRAARGVRGVRLRPNDSVVGMDIANDDRTLLVISENGYGKATKISNFPSHKRGGVGIKAAVVTAKTGPIISVKTIQQDDiEALLVSTQGQTIRVSLKDIPVLGRTTQGVRIMKTSDDDSVASVGLMSERSSNEES---------------------------
>UniRef50_A8PTE9(644-1116:1376) DNA topoisomerase 2 n=1 Tax=Malassezia globosa CBS 7966 RepID=A8PTE9_MALGO  E=1e-113 s/c=0.87 id=24% cov=52%
------RIRNIPISDFINKELILFSMADNI-RSIPSVVDGLKPGQRKVIFSCFKRKL---KTEIKVHQLQGYVSehSAYH-HGDQALTMTIVGLAQDFcgSNNVNLLMPNGQFGSRsmGGKDAASARYIFTAVPRITRLMFHADDEPLLNYLED-DGQSIEPEWYAPVVPQVLLNGAEGIGTGWSTFVPNYNPREVVDNLRRRMAGEE--------YVP---------------MNPWYRGFVGGIEPAGPERFRVTGiarQLDERTWEITELPVRVWTMTYKEWLEERVvgSDKTPAVLREYKEYHTDTSVHFVVELNPRGMEEIERVGPDTFFKLSTMLSTSNMVLFNpegKIKKYATPQEILEDFYFVRLGFYQRRKEHLVDQLKLVYDRLSNQARFVSMI-----IARELSVSNKKKAAIVEELRQLKFQAFPKVEAKAKSVTEEAVEDQEEPDEPANSNTD--YDYLLSMAIYSLTQERVERLLKERDHTE---TELKILLGrSPQNLWD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_B9XEN7(56-573:701) DNA topoisomerase (ATP-hydrolyzing) n=1 Tax=bacterium Ellin514 RepID=B9XEN7_9BACT  E=1e-112 s/c=0.79 id=28% cov=52%
--------VETPLHKRMDFSFLEYASYVIRDRAIPNLADGLKPVQRRILWSLHE---KDDGRFIKVATISGHCA-QYHPHGEAAIGDALVVI----TNKRYLIEGQGNFGNIyTGDPAAAPRYIECRLTELARnELF---NDELTEFVPSYDGRNKEPVTLPSKLPTLLMLGTEGIAVGMSCKILPHNFPELLEAQIAILKKQPFKVL--------PDFPTGGLMDARE-----YADGKGSIKVRAKIK-----AKDESTVVIKEIPPMTTTDSLIGSIEDASRKGKIK-IKSINDFTSEEA-EIEIKAPSGVSADQLIDALYAFTDCEMSISSRIIVIRNNRPVEMTVSEVLRENTAQLVDTLKRELELKEKKLQEELHFKTLVRIFIEN-------------------RIYKKIEQCKTNEAVYEAVYDGFKPFRKEMIR--------DLVDTDVEMLLGVRIRRISLFDINKHREEIDKIKADLSETAKHLKN---LTKYAIGRLEALLEKYGpiYPRLTK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C1E5N4(703-1168:1459) DNA topoisomerase 2 n=1 Tax=Micromonas sp. RCC299 RepID=C1E5N4_9CHLO   E=1e-111 s/c=0.87 id=22% cov=49%
-------------------------------RSIPSVVDGFKPSQRKVLFSCFKRKLKSD---IKVAQLSGYVSehSAYH-HGEASLASTIVGLAQDFvgSNNVNLLVPSGQFGTRlqGGKDHASPRYIFTRLAPICRVIFPECDDALLDYLD-EDGQVIEPEHYLPILPLVLVNGADGIGTGWSTSIPNFNPRDIVANIRRILDDE-----------------------CTERMHPWYRNFKGTIEeeiVKGEIRYNITGKyeiVDETTLVITELPLRSWTTDYKDFLENMLSPKEKnaqPFITDYKEHHTDTTVHFIVTMTPENMAKAQKDGIEKKFKLCAKVSTSNMHAFDekgGITKYSSPEAIMEAFVPLRLDAYARRRAMLIRQAEFELKRMSNKVRFILAVvdgEMTIGRKKKSVLIEELEAAGYDKMPKTAKAAAAADAEPAESGLSDISEEGAPAPADG-----ASYDYLLSMPLWNLTQEKVDELVEEQRVKTAEVEEL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C6XSV0(18-686:977) DNA topoisomerase (ATP-hydrolyzing) n=61 Tax=Bacteria RepID=C6XSV0_PEDHD  E=1e-109 s/c=0.59 id=27% cov=58%
--------------------FLDYASYVILDRAVPHINDGLKPVQRRIMHSLKEM---DDGRFNKAANVIGNTM-KYHPHGDASIGDAMVQIGQKD----LLIDCQGNWGDpITGDNAAAPRYIEARLSKFANEVVFNGD--TTIWQLSYDGRNNEPVTLPVKFPLLLAQGAEGIAVGLATKVMPHNFIELLDASIEALQGHRPNIL--------PDFFTGGMAD-----FSAYNEGMrgGRIRVRAKI-----TEKDKKTLVITEIPYSTTTGSVIDSILS-ANDKGKIKIKKIEDNTAAH-VEIVIQLAPGISPDVTIDALYAFTSCEVSISPNTCIIKDEKPQFLSVNDILIENSMHTKALLKKELEIKLHELQEK--------------------IFFSSLLKIFIQEGMYKNAEYENSVNFEMVVEVLNRLFEPFKPGLYRE-----ILPEDFKKLIDKPMSSITRFDVKKADEQMKALSDEIKVVKNHL---RHLTEYAIAWFQKLKDKYGKgrERKTEIRLFDR--------------VEASK------VALANVKLYMNREDGFIGTGLRKDEFVAD---CSDIDELIVFREDGKCIITKVAD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q73KU9(4-624:703) Topoisomerase IV, A subunit, putative n=2 Tax=Treponema RepID=Q73KU9_TREDE  E=1e-108 s/c=0.64 id=28% cov=52%
------------IESLFNKNFLEYASYVIRDRAIPDLEDGLKPVQRRILHSLFEM---DDGKFHKVANVIGHCM-KYHPHGDASIGNALVVLA----SKELFIDTQGNFGNIfTGDEASAPRYIECRVNEFAKTIFY--NPHITDYTVSYDGRNKEPLAFRAKLPVILAIGAEGIAVGMSTKILPHNILEIIEAEKAFLSGKSFAL--------FPDFPTGGLIDVSE-----YEDGLGKVLVRAKLDT-----SDEKRIVIRELPFGSTTESMINSIEAASKAGKVK-ISEISDYTGEN-VEIELKLPRGVYSADVVDALYAFTECEQSIPCNLLVIKDNLPVQITVTDIIKYHAKQLMQILKDELEYERAMLTERLHL-----RTLERI--------------FIEERIYKKIETMKTAEGVINAVIKGFVPFKKELIR--------DVTEDDVDKLLKIPIRRISLYDINKNREEVREINNRLKEIAKLLKN---LKGYAISVLDGIAAKLPAEefkRKTEIT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q1NV80(57-572:711) DNA gyrase/topoisomerase IV, subunit A n=4 Tax=Deltaproteobacteria RepID=Q1NV80_9DELT  E=1e-106 s/c=0.75 id=29% cov=58%
------------------ENFLDYTSYVIRERAIPDLADGLKPVQRRILQTLHNM---DDGRFHKVANVVGETM-KLHPHGDASIFSALVNLA----NKGYLIDRQGNFGNVhTGDGASAPRYIECRLSPLARETM--FNKELTEFIDSYDGRMKEPVSLPARLPLLLLQGADGIAVGMATKIMPHNFGELLTASKQILREEPFEL--------FPDFPQGGLLDASG-----YEDGNGRLRCRARIET-----RDDKTIVIRDIPYGTTTQSLIESVEKAARAGKFK-ILSIDDYTA-EDVEIEIKLARGFKAEETIKALYAFTDCEIPISPNFTVIREQTPAIMTVSEVLRENTARLRQLLKKELELDLARLREKL-----QARLLEQI--------------FIEERLYKQIEECPSLAVVLTTIDKALKPFAAELVRP--------VSREDLERLLEIRIKRISRYDIERQKKEIKGIRKDIVAVEKNLAD---LTAYAIRFLDDLLKRYGQqyPRRTELTSFKE--------------VQASQ------VALSNLSLAYDPESGFLGTQVKTS--AENRLACSEYDKILLISRSG---WYKVVAVPD--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D2QEJ6(57-686:904) DNA topoisomerase (ATP-hydrolyzing) n=2 Tax=Bacteroidetes RepID=D2QEJ6_9SPHI  E=1e-104 s/c=0.60 id=29% cov=51%
--------------------FLDYASYVILERAVPAVEDGLKPVQRRILHALKEM---DDGRFNKVANVIGQTM-QFHPHGDASIGEALVNIGQK----ELLFDTQGSWGDvRTGDGAAAPRYIEVRLSKFAQDAIY--NDKTTEWQLSYDGRKREPITLPVKFPLLLAQGVEGIAVGLSTKILPHNFNELIDASINILKDKPVSL--------FPDFQTGGLIDVSN-----YNDGHrgGKVRVRAKIE-----EVDKKILAIRDVPYGVTTSQLIDSIVKAAELGKIrikapsRNVAAVVDNTAKD-VEILVHLQPGVSPDVTIDALYAFTDCEVSISPNACVIIGDKPHFVSVTDILRVNTHQTVHLLQRELEIRRSELMERL-------------------LYSSLEKIFIENRIYRKIEECETFEAVLEAIDKALKPHKKLFYRVITQDDLIRLTE--------IKIKRISKYDGFKAEELMRRLEQELAETEDNLAN---ITRFAIAYYKDLQKKYGKgrERKTEI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_O51066(1-615:626) DNA topoisomerase 4 subunit A n=20 Tax=Borrelia RepID=PARC_BORBU   E=1e-104 s/c=0.62 id=29% cov=52%
-----------DIRTVLKDNFLQYSSYVIKDRAIASVVDGFKPVQRRIIHSLFEM---HDGNFHKVANVVGNTM-KYHPHGDTSIYEALVNIA----NKDLFIEKQGNFGNLfTGDPASASRYIECRLTPLAFDVLY--SKEITIYESSYDGRNNEPLLYPAKIPVILIQGSEGIAVGMAAKILPHNFNEILNAVKSELLGESYDIY--------PDFPTGGIVDVNE-----YADGNGKVLVRAKIET-----IDEKTIVIRELPFGETTESLISSIEKAIRKNYIK-VSSINDFTAEN-VAIELSLPRGVYASEVIEKLYHYTNCQISISVNLLLLSERYPVVYTIKDLIKFHAAHLQKILKMELELQKSKILEKI-----FYKTLEQI--------------FIEKKIYKLLETISKEENILSIILSEVLRHKESFSREVLKEDVEN--------LLKIPIRKISLFDIDKNSKDIKILNK---ELKSINSNISSIRGYSINFIDLLLAKYSKEhqRKTKI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D0MV61(666-1254:1329) DNA topoisomerase 2 n=2 Tax=Eukaryota RepID=D0MV61_PHYIN   E=1e-103 s/c=0.65 id=24% cov=50%
-------------------------------RSLPSVVDGLKISQRKVLFACMKRKLTS---EVKVAQLAGYCSEhtAYH-HGEASLHSTIVNMAQDFvgSKNLPLLFPSGQFGTRlqGGKDAASPRYIFTLLQKHTRLVFPEEDDALLRYADD-DGFPVEPVFYVPIIPMLLVNGAEGIGTGWSSSIPCHHPVLVIDNLLKLLDaeeaGDDLSIVELSLMTP--------WAKGFSG--DIRQTGKHSFVSRGNVE-----QVNTSTVRVTELPVGKWVEDYKKFLWDLVGKK---AIRSFSEHHSERDVRFDISMTRSDLAKYAEdaaencdagdsEALVKLLRLEAPLSTSNMHAFnaDGQLvKYETSEDVLRDFYGVRRKLYSKRKRHLEQRQTKEVLRLSNRIRFIQEVSTgsLQKILRERIPKAELIDLLKEHGFAPASAFKEEAIDHMGDLGLAAVGREQGKAGDLDG--SEDYDYLLNTSLMSFTKEFADRLRKEHDTKQDKLQQLQA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q5KSK9(750-1250:1572) DNA topoisomerase 2 n=5 Tax=Basidiomycota RepID=Q5KSK9_COPCI   E=1e-102 s/c=0.75 id=21% cov=51%
------RLEEIPYSEFINKELILFSMADNV-RSIPSIADGLKPGQRKVIWGCFKRKL---KKEIKVAQLVGYISEhaAYH-HGEASLAATIINLAQDYvgSNNLALLSPNGQYGTReiGGKDHAAPRYIFTNAKSITRAIYHPFDDPLLNYLKD-DDVPIEPEWYMPTVPMVLINGAEGIGTGWSTNIPPYNPVDIVANLRRMMKEEE----------PEPMTPW---WRGFKG--EVRPTGKGKYDVVGVA-----TKINDTTVEISELPIHKWTRTFKDELEAMITGekkdkdkdkdkdedgkkdvvKNAGMVKDFKEHHDNLNVLFEVTMNPKDLEKAEEKGLVEFFGLTTKVSTTNMILFDfegKIKKYETPEEILKDFYPMRLAYYQKRKDYQALELSTAYDKLNNQIRFIEMI-----IKKELVVSNRKKADIVAELRKLNFRPFPKVAKTKTAKPDEEEEESEDEEEESGSEAVTDFDYLLGMAIYSLTRERIEKLKQQAHEKEQE-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C0X5K0(1-462:465) Possible DNA topoisomerase IV subunit A (Fragment) n=2 Tax=Enterococcus faecalis RepID=C0X5K0_ENTFA  E=4e-98 s/c=0.78 id=33% cov=52%
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RKSVIINRCQFELDKARKREHIVAGLIKALSILDKVIATIRGSKDKKDAKKNLV----------------------------------SDYAFTEEQAEAIVTLQLYRLTNTDITDLQEEAKTLEQQIAELLNILNNEKELFSVMKKELREVKKQYGNPRLTQIEEEIQEIKIEtaVLVAQEDVVVTVTHEGYIKRSSIRSYTASKPEEIG-----MKEGDFLLYAGEVNTLDHLLLVTNKGNMIYRPVHELPDLRWKEIGEHISQtILNLAIDESIIAVYPYKELSPTKTFVFITKAGMIKQTKMADFEPWRtykSRPTSCMKLKSDqDEITNVYLTNDQDllDVFLVSNRGFGLRYPLYEVPVVGSKAAGVKSMNLKEDDYVVNGLLVHSEGDtpIVIVTQRGGVKRMLAQELTQLGRAKRGLMVLRELKKNPHRVVFMSESTDLDLLVTTQKGTQEVIQSKNYPISERTSNGSFVIDEQKDGQVMEVHEMHSAVIEEE----------------------------
>UniRef50_UPI0000DB6EE1(683-1117:1407) PREDICTED: similar to DNA topoisomerase 2-alpha (DNA topoisomerase II, alpha isozyme) n=1 Tax=Apis mellifera RepID=UPI0000DB6EE1  E=2e-90 s/c=0.77 id=23% cov=44%
-----------------------YSNYDNV-RSIPNMIDGFKPGQRKVLYTCLKRN---DKREVKVAQLAGSVAehSAYH-HGEVSLMSTIINLAQNFvgSNNINLLQPIGQFGTRlaGGKDAASPRYIFT--------MLRYIY------------------------------------------IPNYNPREIIENLYRMMDGAD----------PKPMVP-------------YYKNFKGVIESCGDFRYIINGEisvIGPDKIEITELPIGTWTQTYKETVLEPMlhgTDKTPATITDYKEYNTDTAVHFIIMLNRDKLLDLERDGLHKAFKLQTTMTVTsMCAFDENQclQKYDSVLQILKGFYKVRLEMYHKRKEYLEGILQAEASKLSNQARFIvEKCDGTIVI--ENKKRKDMIAELIRREYESDPVLAW--KLSQNREEEEVAENVDDETVSSTAITKENFDYLLGMTLWSLTKEKKDELLRQKDDKLAELKRLQA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C7U0P4(640-1072:1072) DNA topoisomerase II n=2 Tax=unclassified Phycodnaviridae RepID=C7U0P4_9PHYC  E=5e-89 s/c=0.76 id=27% cov=34%
--------------------------------------DGLKPSQRKVMYACFHKNL---KDEMKVAQLAAYVAdkSAYH-HGEVSLADTIVKLANDYmgSNNINLLEPCGQFGTRlmGGKDASQTRYIFTKLTKDARKIFDPRDDPVLNYLDD-DGRAIEPDFYMPTLPMVLVNGTEGIGTGFSCYVPPFNPKDIKENIQRSLEGHDF-----------------------KEMKPWFRGFKGKVfKEDGTWITEGVWRDTGSRLKVTELPPGRWTQDYKEYLDTLMEKKVISGFTN---NSTTEDVDFEIM---GYTGKDVLKDL----KMRKSFHTSNMHLFHptkGIYKYSSPEEILKDFVDLRLDHYKKRKEHLIK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q6RCM1(663-1205:1458) DNA topoisomerase 2 n=2 Tax=Trichomonas vaginalis RepID=Q6RCM1_TRIVA   E=3e-87 s/c=0.60 id=22% cov=50%
-------------------------------RAIPSSIDGWKPGQRKILWVCLKNNIKND---LKVAQLSGKVSEqaAYH-HGEASLNETIIGMCQDFvgSNNINVFQPIGMLGTRlaGGEDSGSPRYVYTALEKITRTIFMKEDDDLLTY-NTDEGLPIEPVTYIPIIPMVLVNGAKGIGVGWSSEVPQYCPQDIIDNLRRKMNDEPMV--EMTPWYSG----FTGKIIPIQVIKDGVKQPIVKWESRGIVK-----KIDDTTIEITEFTNGIWTYDYKKFLEGLtvgeslnphkkladrkaaaakakrtkkkaaagddpveqadVEEKVNLGgpkISEFREYHTNVSVHFIITVDDSQMREIESVGLREFFKLKSSITATNMTLFNAQNKIVqfnSPLDIINDYYPVRMKYYEERHRYLIDALQLQYKKLSNQARFIREVIAGI-IKVNGVPRATILAALERGNYDLYDDKELTKRIKFADEVIQQHNEeeeeqnefKSESNADHLALLEKGYDYLLAMKIWTLTKEKADKLDDEAKKKNQELEE----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_D2XAH7(645-1085:1089) DNA topoisomerase II n=1 Tax=Marseillevirus RepID=D2XAH7_9VIRU   E=5e-79 s/c=0.68 id=29% cov=32%
-------------------------------RSIPSVFDGLKPSQRKVLYACFSSNIIGKNKKKHVDRLTGEVASvaGYH-HGEKSLTETIIGMAQDFvgcGNNVRLLNPDGSFGTrlRGGKDHSASRYLSSFVEKIARVVFPPEDDDLYEKVF-EDNEYNEPINYIPIIPLIVVNGACGIGTGHSTEIPPHNPLEVCHWIRCWLEEQE--TPKLSPWWKG-----------FNGTTEVEED---KVKTFGVLE-----KMSKTKWKIVETPVGLWTYDCKKHLESLETQK---HIKSFEDKYTDEKASFIINTTKDFIPTI------KNLKLSTTFSLrNMTALD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_UPI0001906031(1-306:455) DNA topoisomerase IV subunit A n=2 Tax=Rhizobium etli RepID=UPI0001906031  E=2e-52 s/c=0.69 id=24% cov=34%
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GLLIAYLNIDEVIRIIREEDEPK-------------------------------------PVMVARWDLTDNQVEAILNMRLRSLRKLEEFEIRKEFDELTKEKGEIEALLASDDKQWQTVAWEIGEVKKKFAKAtevgrRRTQFADapeADEEAIQQAMIEKEPITVVISEKGWIRAL--------KGHIADTATLTFKEGDGLKVAFPAQTTDKILIVTTGGKAFTLGGDKLPGG--RGHGEPLRIMVDMDNDQAVLTAFV---HDPSRKQLIVSTAGNGFVVAEAELIANTRKGKQIMNVALPEETQLLVPVSG-DHVAVVGENRKLLVFPLAQVPEMTR-GKGVRLQRYKDG--------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_UPI0001C38BB9(1-350:350) DNA topoisomerase IV subunit A n=1 Tax=Arthrospira platensis str. Paraca RepID=UPI0001C38BB9  E=1e-50 s/c=0.58 id=26% cov=34%
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ELRSLKRRYSDPRRTRIVssesqesqsvsarsskgvhppskATESKILRPQLPAVEETLVEMTLRGYVRRVTPHNLsRPQSREDITIEAI----DDFPVTSYLTTTAETLVIINRMGKAYPLNVADIPSVSLKSRGVPLITLLspsatkdaSTRPQDLIVAAFlgaglqssPVRPktdadqreraFSDQTDLIMLSAEGKIKRLSGTDFMDLSARGITVMKLKDNDELSYANLAATGDQVVLATSGGRLLRldINADQIPVMGRTAQGSVATRLRKNEQLVGCITLSstgelNNKFILLVSEQGYFKRISLQSLQRSRRGGIGTQMLQFHSRNDACRGLVATTPGEAIYCLTSE--------------------------------------------------------------------------
>UniRef50_C0W364(8-269:310) Possible DNA topoisomerase (ATP-hydrolyzing) (Fragment) n=2 Tax=Actinomyces RepID=C0W364_9ACTO  E=3e-38 s/c=0.62 id=28% cov=24%
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HDALTSQVPTTARSRVGVVTDTGRLVVMEVLSTPEVPRlegapsLAGGQPVGLLVDLEPGETVVGLVPVGEAQREP-VVLATAGGVIKRVKPGD-EPARGESWEVISLADGDRVVFAGIAADTDVLTLVTDDAQLLRFEASKVRPQGRGAAGMAGISLHEGARVIAGASVPAEllAEAVVVTiadaegalpgmDSGSVKVTPLDRYPAKGRATGGVRAQRFLRGEDQLVVA-----------------------------------------------------------------------------------------
>UniRef50_P48354(14-842:842) DNA gyrase subunit A n=46 Tax=Bacteria RepID=GYRA_MYCS2   E=0 s/c=1.21 id=47% cov=94%
-----DRIEPVDIQQEMQRSYIDYAMSVIVGRALPEVRDGLKPVHRRVLYAMYDSGFRPDRSHAKSARSVAETMGNYHPHGDASIYDTLVRMAQPWSLRYPLVDGQGNFGSPGNDPPAAMRYTEARLTPLAMEMLREIDEETVDFIPNYDGRVQEPTVLPSRFPNLLANGSGGIAVGMATNIPPHNLGELAEAVYWCLENyeadEEATCEAVMERVKGPDFPTSGLIVGTQGIEDTYKTGRGSIKMRGVVEIEEDSR-GRTSIVITELPYQVNHDNFITSIAEQVRDGKLAGISNIEDQsSDRVGLRIVVELKRDAVAKVVLNNLYKHTQLQTSFGANMLSIVDGVPRTLRLDQLIRLYVDHQLDVIVRRTRYRLRKANERAHILRGLVKALDALDEVIALIRASQTVDIARAGLIE----------------------------------LLDIDDIQAQAILDMQLRRLAALERQKIVDDLAKIEAEIADLEDILAKPERQRGIVRDELKEIVDKHGDARRTRIVPADGEVSDEDLIAREDVVVTITETGYAKRTKTDLYRSQKRGGKGVQGAGLKQDDMVNHFFVCSTHDWILFFTTQGRVYRAKAYELPEASRTARGQHVANLLAFQPEERIAQVIQIKSYEDAPYLVLATRNGLVKKSKLSDFDSNRSGGIVAINLREGDELVGAVLCSAEDDLLLVSANGQSIRFSATDeaLRPMGRATSGVQGMRFNEDDRLLSLNVVRPDTYLLVATSGGYAKRTSIDEYSVQGRGGKGILTIQYDRKRGSLVGALIVDDDTELYAITSTGGVIRTAARQVRKAGRQTKGVRLMNLAEGDTLIAIARNA--DEDEAAESISESDADTAESP-------------
>UniRef50_P48371(15-915:916) DNA gyrase subunit A n=482 Tax=cellular organisms RepID=GYRA_NEIGO   E=0 s/c=1.09 id=56% cov=97%
---------PVSLEDEMRKSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMHELKNNWNAAYKKSARIVGDVIGKYHPHGDSAVYDTIVRMAQNFAMRYVLIDGQGNFGSVDGLAAAAMRYTEIRMAKISHEMLADIEEETVNFGPNYDGSEHEPLVLPTRFPTLLVNGSSGIAVGMATNIPPHNLTDTINACLRLLDEPKTEIDELIDIIQAPDFPTGATIYGLGGVREGYKTGRGRVVMRGKTHIEPIGKNGeRERIVIDEIPYQVNKAKLVEKIGDLVREKTLEGISELRDESDKSGMRVVIELKRNENAEVVLNQLYKLTPLQDSFGINMVVLVDGQPRLLNLKQILSEFLRHRREVVTRRTLFRLKKARHEGHIAERKAVALSNIDEIIKLIKESPNAAEAKEKLLARPWASSLVEEMLTRSGLDLEmmRPEGLVANIGLKKQGYYLSEIQADAILRMSLRNLTGLDQKEIIESYKNLMGKIIDFVDILSKPERITQIIRDELEEIKTNYGDERRSEINPFGGDIADEDLIPQREMVVTLTHGGYIKTQPTTDYQAQRRGGRGKQAAATKDEDFIETLFVANTHDYLMCFTNLGKCHWIKVYKLPEGGRNSRGRPINNVIQLEEGEKVSAILAVREFPEDQYVFFATAQGMVKKVQLSAFKNVRAQGIKAIALKEGDYLVGAAQTGGADDIMLFSNLGKAIRFNEyweksgndeaedadieteisddledetaDNENTLPSGKNGVRpsgrgsgglrGMRLPADGKIVSLITFAPETEesglqVLTATANGYGKRTPIADYSRKNKGGQGSIAINTGERNGDLVAATLVGETDDLMLITSGGVLIRTKVEQIRETGRAAAGVKLINLDEGETLVSLERVAEDESELSGASVISNVTEPEAE--------------
>UniRef50_D1R591(1-827:865) Putative uncharacterized protein n=1 Tax=Parachlamydia acanthamoebae str. Hall's coccus RepID=D1R591_9CHLA  E=0 s/c=1.17 id=48% cov=94%
MSYTENEIIvPRNVEDEMKDSYLRYSMSVIIARALPDARDGLKPSQRRILYAMRQLNLSPGGKHRKCAKISGDTSGDYHPHGEQVIYPTLVRMAQGWLMRYPLVDGQGNFGSVDGDQPAAMRYTEARLTHASVQLMEDLDKNTVEMVPNYDETKKEPTVFPAKFPNLLCNGSSGIAVGMATNIPPHNLNELIQATLLVLQNPAVSIDEIMGVMPAPDFPTGGIICGYRGIKEAFHTGRGRLLLRAVIRVEENEENpDKQRLIVDEIPYNVNKSRLIEQIADLINSKTITGIADLRDESDKDGMRILIELKRGEIVEVILNQLFKYSDLQITFGCNMLALDKGLPKVMNVKQLIAAWVDHRIEVVRRRTRFELNKAEARAHILEGYLKAIQHMDEVVRVIRASNNREEARDELIQR----------------------------------FDLTERQANAVLDLKLYQLTGLEYEKINEEYRELLQKIDYLRAVLASEAMVRDIIREELLEIQKNHRSGRKTQIIAAESEVNMEDLIANESVIITISEDDYIKRMPVDTFREQRRGGQGIAGMHLKrEEDAIKGLYVASTHDYLLIFTNLGRCYWLKVWQIPETGRKSKGKPLINLLEdIRPDEKIATVLRVSNFEQQAYILMATKKGIVKKTELSEFSHPRRKGIWALDIVEGDEVVTARLVSDSQQIMLFTYHGMAVRFDQGKVRPMGRTARGVKGVTLKDDtDYVVGCEAVNGTETILIVCENGFGKRSNVEDFRQTNRGGVGVRSIITSERNGNVVGALCVTDEDGMVMMSAQGQTVRITMKDLRVMGRNTQGVKLANLKEGDYLVAIQKLEVSDDVDNAKVDTQPSA-------------------
>UniRef50_C8PKZ3(9-906:914) DNA gyrase, A subunit n=2 Tax=Campylobacter RepID=C8PKZ3_9PROT   E=0 s/c=1.04 id=49% cov=95%
-----QEIIDIDVEESIKTSYLDYSMSVIIGRALPDARDGLKPVHRRILYAMNDLGVGSRQPYKKSARIVGDVIGKYHPHGDTAVYDALVRMAQSFSMRIPSVDGQGNFGSIDGDGAAAMRYTEARMTPLAEELLKDLDKETVDFVPNYDESLNEPDVLPARVPNLLLNGSSGIAVGMATNIPPHSLDELVGGLLILLENKNASLEEIMGEIKGPDFPTGGIIYGKKGIIEAYKTGRGRVKIRAKTHIE--KKASKDVIVIDELPYQTNKARLIEQIADLVKEKQIEGISEVRDESDRDGIRVVIELKRDAMSEIVLNNLFKQTTMEATFGVIMLAIDGKEPKIFTLIELLKLFLNHRKTVIIRRTIFELQKARARAHILEGLKIALDNIDEVIDVIRNSADTNVARENLMSR----------------------------------FDLSEAQSGAILDMRLSRLTGLEREKIEEELKEILAEIKRLDAILKSEELIEGIIKDELLEIKDKFKCPRITEIVDDYEDIDIEDLIANENMVVTITHRGYIKRVPSKTYEKQKRGGKGRVAVTTYDDDFIESFFTSNTHDTLMFITDRGQLYWLKVYKIPEGSRTAKGKAVVNLIQLGADEKIMAIIPTTDFDPSKSLVFFTRNGIVKRTNLSEFKNIRSLGIRAISLDEDDTLVTALIApnsaeemqnykggalsgddldggeaeeileqteqdilegsedeisdeisqdegaqdgepqsTNENMLFIATKKGMCLKFNLNKIRQMGRIARGVKGIKFKEkGDEVIGAAFILSDmQEILSVSQKGIGKRTTASEYRLTNRGGKGVICMKLTNRTGELIGVVMVDEEMDLMALTTSGKMIRVDMQSIRKAGRNTSGVIVVNV-EGDDVVSIATCPKAEEGDEGEADELAQDENllNSNLDSKDSQSDGPSDE
>UniRef50_B1ZTK3(1-830:830) DNA gyrase, A subunit n=3 Tax=Verrucomicrobia RepID=B1ZTK3_OPITP   E=0 s/c=1.11 id=46% cov=93%
MYTASEKLSSANITDIMQTAYIDYSMSVIISRALPDARDGLKPVQRRVLYAMLREGLLHNRAFDKCAGVVGEVLKNYHPHGDSSVYDTLVRMAQPWVMRYPLIDPQGNFGSVDGDPAAAYRYTECRLNAIAEDLLRDIEEDTVDFAPNYKESTTEPTVLPAALPNLLMNGSTGIAVGMTTNIPPHNLAEIIDATCAIIDNPRISVDELCTIVQGPDFPTGGVIAGREGILSYLKTGKGIVRTRGKAHTE-EMKGGMEQIVVTEIPYNVNRATLVTRIAELVGDKQIDGIRDLRDESDENT-RIVIELKRGEQSKVVINQLFQKTALESSFGVTLLALDKKRPKQMNIKELIECYIEHRREVVTRRTRFRLKQAEDRAHILEGYIIALDNLDDFVKIIRASQNREEAKVRLMAK----------------------------------YPLSERQTDAILELRLYQLTGLERGKIEAEYLELMKLIEELRGILESEPKLLALIKKELAEMKEKYTSPRRTEIIAAAGEFRMEDVIPNEGCVITVSHLGFIKRTPVAEYRSQRRGGKGVIGAETYEEDFVANLFTASTHDYILFFTSIGQCHAKKVYDIPEGTRASKGKSVSSFLRLAEGEKIAAMLCVKDFAEDRYLVTATKRGIIKKSALSDYANaTREGGLIGINLQEADSVIGTVLTTGENELILVSHQGLAVRFRERDpesgeelFRATGRATGGVTGMRFKlKSDYLDVIEVVDHEAKFLVASEAGLGVRTRFEDYRLINRGGSGVWAIDLPEDGSiKLAGALSVREDDEVMLLTAKGQSIRCPVKDIRETNRGAKGVRLVTLEPGDKLLSIARIVETEEESGAEATPP----------------------
>UniRef50_Q5YLB5(88-935:935) DNA gyrase subunit A, chloroplastic/mitochondrial n=14 Tax=cellular organisms RepID=GYRA_NICBE  E=0 s/c=1.08 id=45% cov=93%
-----ERVVLTELHKEATEAYMSYAMSVLLGRALPDVRDGLKPVHRRILYAMHELGLSSKKPYKKCARVVGEVLGKFHPHGDTAVYDSLVRMAQDFSLRSPLIRGHGNFGSIDADPPAAMRYTECRLEALTESMlLADLEQNTVDFVPNFDNSQKEPSLLPARVPNLLLNGASGIAVGMATNIPPHNLGELVDALSALIHNPEATLQELLEYMPGPDFPTGGIIMGNIGILEAFRTGRGRVVIRGKTDIElLDSKTKRAAIIIQEIPYQTNKASLVEKIADLVENKILEGVSDIRDESDRSGMRIVIELKRGSDPAIVLNNLYRLTALQSSFSCNMVGILNGQPKLMGLKELLQAFLDFRCSVVERRARFKLSQAQERNHIVEGIIVGLDNLDEVINTIRK----------------------------------ASSNALAAASLRKEFELSEKQAEAILDISLRRLTALERNKFVEEGKSLRTQISKLEELLSSKKQILQLIEEEAIEIKNKFFNPRRSMLEDtDSGDLEDIDVIPNEEMLLAISEKGYVKRMKPDTFNLQNRGTIGKSVGKLRVNDAMSDFLVCRAHDKVLYFSDKGTVYSSPAYKIPECSRTAAGTPLVQILSLSDGERITSIIPVSEFAADQYLVMLTVNGYIKKVSLNYFASIRCTGIIAIQLVPDDELKWVKCCSNNDFVAMASQNGMVILTPCANIRALGRNTRGSVAMRLKEGDKVASMDIIPDalqkeldktlevqqrqyrsmkGPWLLFVSESGYGKRVPVSRFRTSPLNRVGLFGYKFSSEDC-LAAVFVVgfslgedgESDEQVVLVSQSGTVNRIKVRDISIQSRYARGVILMRLEHAGKIQSASLISAADADPEDEDATAVAA-------------------
>UniRef50_B5Y5U7(1-817:818) Predicted protein n=1 Tax=Phaeodactylum tricornutum CCAP 1055/1 RepID=B5Y5U7_PHATR  E=0 s/c=1.09 id=43% cov=90%
---------------------MQYALSIIMGRAIPDARDGLKPVHRRILYAMDQLSLYPNTGHRKCARVVGEVLGKFHPHGDMAVYDALVRLAQHFSTAYPLIDGHGNFGSIDADPAAAMRYTECRLTKLSQaALLEDLQDDTVDFLPNFDGNEIEPAVLPAKLPILLLNGSSGIAVGMATNIPPHNLNEIMTACTALVKarqgGAAVTDKKLLQMVPGPDFPTGASILSTGGTEKLYTTGNGGIVMRAVTKIEkittgRKSSITRTAIIVTELPYQVNKAALLEKIAGLVNEKKLDGIADLRDESDRDGIRVVIELKRDAVAAVVLNNLYKKTPLQTTFSGNFLALMTAnrdsssslVPQRFTLRQAMDCFLDFRFETIRRKSQFQLTKVNARSHIVAGLLMALDKVDMVIQIVRASADQQAAREALYIE----------------------------------LGTSSEQTDAILKLQLGQLTRLNKGKLESEKADLEESRESLTHLLEVDDAVYDVMREEFIDMMKRFGGERKSSiIVEDDGDFCDMDLIENSRSVIVVTRGGYIKRMPLKTFESQGRGTRGKRGTSdggESADSEVAHCFTCNDHDTLLMVTQNGIAYGLRAYQVPIAGRTAKGQPIPSVLPVRGDEVITAILPVSEFSDEEYVVLTTEQGWIKRTPLDAFEKLSSRGLTIATLEDGDRLKWCHRVRNEDDILIGTVGGMATRFGAAKLRPTGRTSRGVRAMKLREGDTIADMNVLSgkNKEYILTVTAQGYGKRIATSEFRAQARGGVGVIAIKFKrgQEEDKVSCLRIVKDDEEILVITARGIMVRQKASDIPSQGRSATGVMVQRVDDGDHISSVSIVP-----------------------------------
>UniRef50_B8CXA6(1-795:796) DNA gyrase subunit A n=1 Tax=Halothermothrix orenii H 168 RepID=B8CXA6_HALOH  E=0 s/c=1.07 id=43% cov=91%
---MAEKIRSIAIEDKMKDSYLSYSLSVIASRALPDVRDGLKPVHRRILYAARELGLTHDKPHKKSARIVGEVLGKYHPHGDASVYDAMVRMAQYFNQRYCLIDGHGNFGSIDGDSPAAMRYTEARLTELAEDIMADITQDTVDFVDNFDGSLQEPEILPTKVPNLLINGASGIAVGMSTSIPPHNLGEVVDAMVHLLKHPNAKLETIMKYIPGPDFPTGAKIVGLSGIKKAYKTGNGKITLRARTQIEKKGR--KKQIIIKEIPYHLNKVKLLEDIAELINKGKIDNVSDLRDESDQEGLRIVVELKSGADPDIILNQLYKFTSLQTNYRINMLALDGKQPRVMDLITILKNFINFRRQVITRRTKYKLNKAKERFHLLQGLITAIDKLDLVISIIRHSKSTKEARQKLQEKLV----------------------------------ITEKQAEAILRMRLQKLVGMEEEKLHQESAGLEEQIKYYKKILNNKNELDKVLKKELLDIKNKYADKRKTEIIEDEEKaiIEKTDLIKKEKVFLTFSYRQNIKRTTSSEY------------ARAGKNDYIIDTMTGTTLDTLLFFTNTGDVYTLPVHKIPEHHGLSTGDNIKDFLKIPLSKKIVKVICLNEETKEKYITIATKQGMVKKTIGGEYQTTYSR-IKAIKLNKGDEVVGVEITDGNQEILLGTKKAKTIRFEEDSVSDTGRNTIGSIGIKLAKGDEVVSFNLVNNNTSVVSISKTGRGKRSPIEEYNPQNRNGKGLKTCGSSIY--KMAGVICANPDDYILITTGNEKLYTVKVNDLTETSRTGNMYEVVSLKNDDKITGVEKLPFAPEEDN----------------------------
>UniRef50_C8NZH8(4-817:822) DNA topoisomerase IV, A subunit n=1 Tax=Erysipelothrix rhusiopathiae ATCC 19414 RepID=C8NZH8_ERYRH  E=0 s/c=0.97 id=37% cov=88%
-----DSLIKLPIEDIVGERFGRYSKYIIQERALPDVRDGLKPVQRRILYAMFHDKNFYDKPYRKSAKTVGLVIGNYHPHGDSSVYEAMVRMSQSWKMNMPLIDMQGNNGSIDDDPAAAMRYTEARISKLSQKLLENIDEEVVPFVLNFDDMTTEPSVLPARYPNLLVNGSTGIAAGYATNIPPFNLNEIMDASIYRLHNPNCSVEEIMTMVQGPDFPTGAIIQGQEGIEDIIRKGKGRIVVRAKAEIVENKS--MKQIVITELPYEVIKSNVVRKIDELRFTKASEGfgdVMDVRDESDRTGLRIVIDCKRDANVESILNLFYKYTELQVYYNANMVAIVDQRPKVCGLLEVLDAYLKFRQEVVLNRSKYRYEQKEKRLHILEGLMKATSNLDEIIAVIRSSNNRSESRNNIMAE----------------------------------FGFTEAQATAIVDLQLYRLSSTDINALRDEFAKLANELEYLDLVINNIDMLNNMIVKEFMEIKEAFDTPRRSVIEAEISELEVDhlSLITNEAVMVTVSRDGYLKKVSLRSY-----GSSQKDVIALMDEDMPVFSSEVETTDYLVFVTSRGRYGMILVHEIDEARWRDTGSHINQYMKCDPNEKIISVFTLKSFDTYRFIVTSTASGMIKKTAISELEVKRTNRLYdVMKLGKHDELVGAVITSNDEHLLLVSKEGQCMRLDLAEINPIGLRAKGVIGMKLKLNDRVVSTMGLSDESEVVFVSDRFQMKRIKAQDIAINNRATQGTSIVKMVKSNPHCLAELFVGNIQDHILIYNDHTSI-IPIKDVPIMS-----------------------------------------------------------
>UniRef50_A0L827(1-720:754) DNA topoisomerase IV subunit A n=1 Tax=Magnetococcus sp. MC-1 RepID=A0L827_MAGSM  E=0 s/c=1.05 id=42% cov=81%
MSNTFEQIDPCNLREELESRYLAYALSTIISRSLPDVRDGLKPVHRRILFAMRALRLDPNSPYKKSARVVGDVIGKYHPHGDQAAYDAMVRLAQEFAVRYPLVDGQGNFGNIDGDSAAAMRYTEARLTSVAKALLEDLEMDTVDFMPTYDGSMEEPVVLPARFPNLLANGSSGIAVGMSTNVPPHNVGEILDACLLLISKPNCSIEELMQHLPAPDFPTGGILMaDHAERLEVYSEGRGSLRLRARWAVE-DLGRGLWQIVVTEIPYQVQKSRLIERIAQLVIDRKCPFLTNVRDESDEN-LRIVLEPRaRTLDPELIMHFLFKHSDLESRASFNLNVIVGGhRPEVLDLKGILRHWLDHRFVVHTRRASYELKKIRERLHLLQAFLIVHLNIDEVIEIIKKNDDPAPV---LMAR----------------------------------FSLDEIQAEAILNMRLRNLRKLEEMKIRKEMEELQARADLLEAMLADDKIMWKAIRDELKATRKEFADVRRTEICGSVEDVHVrpEDFVEKEPISVILSQMGWVK--------ANKGHDVNTEVLRFKGDDLLLRSFPCYTNQSVSFISQSGKLFTILASNLPAGK--GFGEPLTSMFDLDGGDRVLWALPV---DPEQEYLLITRLGQGFRVKGVDLIANQRKGKQLITLKSGDQPLHLHPVKGP-WVGSISRSRRLLIFPIEQFPLMAK-GKGVRVQKLGADEVVVDVTTFTDEEGFVLDS----GKKTKhVTDYDQwhGNRAGRG---------------------------------------------------------------------------------------------------------
>UniRef50_Q0SRA9(12-931:979) DNA gyrase/topoisomerase IV, A subunit family protein n=37 Tax=Clostridium RepID=Q0SRA9_CLOPS  E=0 s/c=0.80 id=41% cov=92%
------NIIRMPLEEVMPDNYLPYAVEVAKDRALPDVRDGLKPVHRRILYGAYMLKAFPDKPYYKSARIVGDILGKYHPHGDSSVYDAMVILAQNFSTRAPLIDGHGNWGSIDGDGAAAMRYTEARLSSISMEMLRDIEKNVVDMVPNYSDSEMEPKVLPARYPNLLVNGTFGIAVGLSTNIPPHNLREVIDGTLAYIDNNEITTRELMNYIKGPDLPTGGVLIGEKTLLSAYETGEGKVTLRAKAKIET-LENGRLGIVITEFPYRRNKARILQTISDMTGDKRhakaLDGIVDIRDESDRTGIRAVIEFKKAVDhdmADKVLKYLYKKTDLQGNISFNMVALADGKPETMGLKTIISHYVNHQKDVVTRRTKRELEVAEKRFHIVEGFIKAIGIMDEVIATIRASKSKKDAHENLVLK----------------------------------FGFTDLQAEAILELMLYRLTGLEIKVFQKEHKELSKKIKALRKILENESVLLGVIKDELKEVAEVYGDERRTALIEDESEakIDLEELIVAEDVMVTLSNEGFIKKIPLKTY---NRSNVDENEIEYREGDYLKFLIKSNTKDTLAIFTDKGTVYQIKCNSVADKKWKDKGERLEDLIrGLSlEDEKIIALESIENFLPNKCFKFITANGLIKKTTLDKFVTAYSK-LMAIKLKNDDLLASVSLIDSQDEerfVEIETTNGLNFVVSEPELEFTDRNILGVQLVPLKSGNQIKSIRFVDNyeykefiiginkkgniktfsnmnsnsyekvkvnsfrniiafsnkgkvfkfpayllqnteesnisdlvdgfekdeliikvapinefgkigeDLFVYFFSREGLVKKTSLREF-------LGefnnQIAYKFKTPKDELVNVDINFENATVILVTKNGMGIKFLATAINPMGRIASGVTGISLKDDNKVI-FGKVIPPSEGIDDKTLEA----------------------
>UniRef50_B4W7D2(12-686:737) DNA topoisomerase IV, A subunit n=1 Tax=Brevundimonas sp. BAL3 RepID=B4W7D2_9CAUL  E=0 s/c=1.04 id=40% cov=76%
------RIIDEPMETALSRRYLAYALSTITNRALPDVRDGFKPVHRRILYAMHQMRLNPQAAARKCAKVVGEVMGGYHPHGDASIYEALVRLAQDFAQRYPLVDGQGNFGNIDGDSAAAMRYTECKLTPAAVLLLDGIDQDSVDFRATYDDQDEEPVVLPAGFPNLLANGSSGIAVGMATSIPPHNVGELIDACQMLLDRPEATTAELVQLVPGPDFPTGGVaVEGHASILDAYETGRGGVRLRARWETE-DLGRGVWRIIVTEMPYQVQKSRLIEALADLIEHKKAPLLGDVRDESA-EDIRLILEPKnRTIEPEMLMESLFKLSDLEVRFPINMNVLDaDGTPRVMGLKACLRAFLDHRREVLNRRSQWRIARVEKRLHLLEGLRIVFLNIDEVIRIVREEE---QPKAVLIAR----------------------------------FGLTEVQADFILDTRLRQLARLEEMTIEKEFKALSEELAHLQALTSSEGKQWKAISKELEAVRKALISPRRTTIADAVDTsafVAPEAFIPREAITVILSERGWI--------RAAKGKVEDPSELKFKEGDQLAYLVPAYTTDKLLVGASDGRIFTIGADKL--ASGRGHGEPLRLMIDLDEKAEIINVLA---HQPGGKLLIASKAGYGFIAPEDDTLAQKRGGKQVLN---GDMLAMLRIpqTPTADHVATIGENIKTLIFPLDELPEMGR-GKGVR---------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_Q7NB60(5-770:797) ParC/GyrA n=1 Tax=Mycoplasma gallisepticum RepID=Q7NB60_MYCGA   E=0 s/c=0.90 id=34% cov=82%
-----KKVFQKDLDDIMSLSFGRYAKYIIQERALPDIRDGLKPVQRRVLYGMYNLGLYYNKSYRKSAATVGEVIGKFHPHGDSSIYEALVRMTQSWKNNIPLIDMQGNNGSIDGDNAAAMRYTEARLSHYGNLMLENINKETVNFVNNFDDSEVEPTILPSLLPNLLVNGSTGIAAGYATNIPPFNLKELIDVIIHRIDSPNCKLESILKLMPGPDFPTGGIILDDDGIKNAYLTGKGKIVIRAKIVNEND------QLVVTDIPFETNKASIIRSIEEILEANKLPQLEEVRDESDRFGIRVVLQtnTKDEKVLATIKNYLYKYTQLQINYSFNNVVIDQKKPIQMSIFNYLDSYLNHAYTILRNAISFDLKKDQKRLEVINGLIKATSIIDQIILIIKKSKDKQDAINNLINK----------------------------------YQFSAIQAEAIVSLRLYRLTNTDILALKEEKKSLDTNIKQYQLLLKDQNALNDHLKEILRSYKKLFNTKRRSTIGGNIEKlvINEASIIEKKELYLVSSVDGLIKTIAYDQNKQLNP-----TSLKIKQDDYLSDLIKVSSLNKVAFITNYGNVVVINAHKIKQAKPREIGMDINELTTIKDNEKIVKLVELS--DQNDRIVLVSKYGMIKQISVNDLVNIKStKPTTCMSLKDDDELVCANLIsDPNAELIIITKNAYALRFFINEVNLTGLKSMGVRAIKLKTNDQVIGFDQIKNSIDQLVLVKNKQIKKLKVSLIENQSRANQG---------------------------------------------------------------------------------------------------------
>UniRef50_A4JTQ2(56-798:808) DNA topoisomerase IV subunit A n=34 Tax=Proteobacteria RepID=A4JTQ2_BURVG  E=0 s/c=0.91 id=38% cov=80%
-----------------ERAYLDYAMSVVRGRTLPDVEDGQKPVQRRLLYAMNDMGLTATAKPVKSARVVGDVLGKYHPHGDQSAYDALVRLAQDFSMRYPLIDGQGNFGSRDGDGAAAMRYTEARLTPFADLLLAEIDQGTVDFQPNYDGAFEEPSLLPARLPVLLLNGASGIAVGMATDIPSHNLREVADACSLLIRRPDATFGDVMSVLPGPDYPGGAQIISdIADIHKVYEGGRGSLRVRARWSLE-QLARGQWQIAVTELPHGVSTQKVLEEIEELTNPKIKAGkkaltqeqgnmkalllsvLDSVRDDSDeKHPVRIVFEPHSSRQtPEQLMNVLLAHTSLECNASVNLVTIgLDGRPQQKGIVPALTEWVEFRYRTVTRRTEHRLAEVERRIHILDGRMIAFLNIDQVIKVIRESD---EPKRDLIA----------------------------------TFHLSEVQAEDILEIRLRQLARLEGIKIEKELAQLQDEQRHLQSLLADRAAMTNQILKEIEADKQKFGDDRRTLIESAEKVTSGAVVpTADDPVTIIVSRSGWL--------RARSGHGIDISTLTFKAGDDLLASIETRTSTSLAVFDTNGRCYNVASALIPTG--RGDGVPLTSLIELQGGGRLTHVIVI---DQTANYLIASSGGYGYVCAGADLLTRQKAGKAFATLEPG-EVMHPPAKIAGDTVSAVCSGGRLVLFPLSEVKVMPK-GKGVKLMELEARETLVAVAIGDGASCIVSTTS---GKPialtgTALDKYRL-HRARKG---------------------------------------------------------------------------------------------------------
>UniRef50_C5CST5(22-782:798) DNA topoisomerase (ATP-hydrolyzing) n=1 Tax=Variovorax paradoxus S110 RepID=C5CST5_VARPS  E=0 s/c=0.85 id=38% cov=78%
------------LADYAQTAYLEYALSVVKGRALPDVSDGQKPVQRRILYSMSRMGLGFGGangtvgaKPVKSARVVGDVLGRFHPHSDQAAYDALVRMAQDFSQRYPLADGQGNFGSRDGDGAAAMRYTEARLARITSLLLDEIDEGTVDFIPNYDGSTEEPRLLPARLPFTLLNGASGIAVGLATEIPSHNLREIADACVALIKsNGKLSDEELLQIVPGPDYPGGAqIISGPADIADAYRTGRGSLKVRARWKIE-DLARGQWQLVVNELPPGVSTQKVLEEIEEITNPKVKAGkkalsadqtqlkaamlsvLDVVRDESSKDaAVRLVFEPKTSRISqDEFITTLLAQTSLETSSPINLtMVGIDGKPTQKSLRQMLNEWIAFREVTVEKRSRFRLNKVMDRIHILEGRQLVLLNIDEVIAIIRAAEDPKAA---LIAR----------------------------------FNLSEVQAEDILEIRLRQLARLEGIKIQQQLDELRTEQKKLEDILGSPAALRRLLVKEIEADAKTFEDPRRTLIQAEKRAVA-EVKVVDEPVTVIVSQKGWVRAQKGWASEKAAGNGGTAPEYSFKSGDTLYGAFECRSVDTLLVFGSAKdksvRVYTVPVASLPGA--RGDGQPVTTLIELDAGTHVTHFFAGP---VGASVLLANTGGYGFIATVENMMSRQRGGKAFIDVGEGEQLCrpslvggasGAEPMPAATHVACASTGGRILTFDIAELKSLPKGGRGLTLIDLDAKDTLAGA--------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C8NBL7(7-739:749) Topoisomerase IV subunit A n=1 Tax=Cardiobacterium hominis ATCC 15826 RepID=C8NBL7_9GAMM  E=1e-178 s/c=0.86 id=38% cov=73%
----------------VEKAYLDYSMYVILDRALPHIGDGLKPVQRRIIYAMSELGLSHQSKHKKSARTVGDVIGKYHPHGDSACYEAMVLMAQDFAYRYPLVDGQGNWGSADDpKSFAAMRYTESRLTGYAKTLLAELEQGTVEWVANFDGTLQEPARLPARLPNILLNGGSGIAVGMATNLLPHNLGEVVAACRALIADPLLTDDALMQYIPAPDFPTGGELVSaREEIAALYRTGRGAVRLRATWHLEDG------NIIIDQLPYQVSGSKVQEQIAKQMQAKKLAWLEDLRDESDHEhPIRLVLVPRSNrVDHERLMQHLFATTDLEKRYSAQMNMIgLDGRPQVKNLGQILREWLVYREETVRRRLNHRLHAVNERLHILQGLLIAYLNLDEIIRIIR---TEDEPRPVLMA----------------------------------TFALSEAQAEAILNTRLRHLARLEEIQIRAEQEALAAEQQHLHELLQSRERLLTLIADELAADAATYGDARRTVIIEREAAVALDetELTPSEAVTLILSKMGWI--------RGGKGHAIDGAALTYKNGDAYLTQISGRSNQQACLLADNGRSYTLALHGLPSA--RSYGEPLSSSMSIDAS---AHIIAAAIIEPERRYLIAADNGYGFLIPGAELTSKTKSGKTLITPGGASRAITLqALPDGETDILAISNEGRVALIPAEEIPEL-----------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_C7H694(29-715:749) DNA gyrase subunit A n=11 Tax=Bacteria RepID=C7H694_9FIRM   E=1e-169 s/c=0.87 id=33% cov=77%
------------ITSTLETNYMPYAMSVIVSRALPEI-DGFKPAHRKLLYTMYGMGLLKGAR-TKSANIVGSTM-HLNPHGDAAIYDTMVRMGRgNESLLVPFVDSKGNFGkaySRDMSCAAA-RYTEAKLEGVCEELFRDIDKETVDFVPNYDGTTTEPTLLPVTFPTILANNTLGIAVGMACNICSFNLAELCATTVALMKDPKHDISTTM---PAPDFVGGGQIlYDEAQMREVYENGRGSIKVRARYNVVP----GENMLEITQIPPTTTVEAIMDKIAELVKAGKIKEISDMRDETDLNGLKLTLDLKRGVDPEKLMAKLYKTTPLEDSFSCNFNVLVSGQPRVMGVREILQEWTAFRMECVRRRTYYDLHGKEKRLHLLKGLAAILLDIDKAIHIIRTTEEETEVVPNLM----------------------------------IGFGIDEVQADYVAEIKLRHLNREYILKRTGEIEQLEKDIADLNDILAKPARIRRIIINELNDVAKKYAQPRRSEILYDlpeEESGAEEEVIPDYPVTVFFTREGYLKKIPPQSLRTAGAH-------KLKEGDEIIHQVETRNNVEALFFTDKQQVYKVRLNELEDGKVAQMGIYLPGRLGMDEGENILAMVITGDYSG--YVLFFFAGGKCAKIPLASYATKQNRRKLLKAYSDKEPLAKLLFLPEDTELAIRTSAGRMLLVNTAQIAAkTTRDSQGVAVVTLKKNQTIASVV-------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_A5K033(152-1142:1263) DNA GyrAse a-subunit, putative n=2 Tax=Plasmodium RepID=A5K033_PLAVI   E=1e-142 s/c=0.51 id=31% cov=83%
---------DVEICELLSKNFLSYANFLILNRCLCDYRDGLKTVQRRIIWSMYEINKGAEKRsYKKCARIVGEVIGKYHPHGDKSVYDALVRLAQRHHNSNVLINGYGNFGSVEY-NAAAMRYTEAKISNFCYDvLLDEINEENVEYVRNFDGNEIEPKVFCSKVPLLLINGCSGIAVSILSNIPCHNLVDVINCTISFLLNPSIREDHLSAIIKGPDFTTGGIIISKpNELQNVYHTGRGSIEIRsnvfleytkddkqyvthvnnlANLHPEDIDSRGSKKLVIKNLPPNVKPNELIENMINILNEKKNEHeniLQKIRDESEKEDMRIVLELRKNTQVEQINDFLsfiFKYTQMQTTYHCNFVCIgHQNSYTQFSLKSFLQLWCENRIKFIRNNLTIKNKNLQKELHIIDLYILIQKKILEIISFLQKNQNIEEIKNFFKKN----------------------------------FQLNDYQIQHILSMKIQKLVNIKNVHFGPHKEKILTRMRDNRDLIADVDRIKRLIIEELAYIKNKYGtssagrlptpqgvkykyvyispsagghplkdhfdpplppqrddppafaknagdtkeekeklrsgvdpDEERTweeqhmgeqhigeqHIEEQHIEeqhieeqhieeqhieeqhieeqhieeqhieeqhieeqhieeqhieeqhieeqhieevdpplpkgknergvhhtggtqrgaketdpppvhyrhtyidcvhADVKDVYNNDHVLVLITYGGYVKKIKVAEKLKNHqnntiklsnvkyilkeneerrlnvggaasgaasgedsGGENGVATSSANPTSAntanaancykVKKSILCRNKDRLLLTDSQNKAYVLDVCDLQTSSYDSKGTPINQVVHCSKS--ITGMAKFEESK--KYLIVCSENGKMKIINNDVFLKKKKKG---IRLFKNKKDIHFSYCNFSDNCIVGTASGHIIQFPLSNFKISKKNSLGNKCISLGKNDKVVDLLTYENDEKsvkkfqIIFLSKGGHGKMVNLGELKVQKRRGKGYKIMKFK--------------------------------------------------------------------------------------------------
>UniRef50_C0QRN3(2-1216:1217) DNA gyrase subunit A n=9 Tax=cellular organisms RepID=C0QRN3_PERMH   E=1e-105 s/c=0.32 id=27% cov=90%
-----SEIIKQPIEEEVKSAYLDYAMSVIVGRAIPDVRDGLKPVQRRILYAMNELGLYPNKPYKKSARVVGEVLGKYHPHGDTSVYDALVRMAQDFTLRYPLIQGQGNFGSIDGDPPAAMRYcvtgdtlintdrglikikdivpdseensdnpINIKVQSLNRkinhsDMFFNSGKHKTIKLETEEGYEIEGSFNHPVLTWTTENGK--PVYKWKT-------LDSIRAGDYLVVSRENDIDSDQDLITEEEAVLLGSLVSEGYISENRAGFNNTDEEYASVfenaykdiygdtfcRYERTLKSGKTLVE-----YQIHHKEIIQDIREKEFDKK----------SSDKEIPFVVLQSSKRVQRAFLKALFEgdgtvyetaravnisysskskkllkqlqvlllNFGIVSRIhrdkqnyrliisGYQNIKLFKEKvgflgKKQEKLIKLVEkiykketansktDFIPFIADYIRDKYrgkgfnEWLSKHSLDRYHKIEKYWDTLSNIlDEedrsllkellynryyfakvktveetgekiVYSIRVKSdchsfvgngivnhntearltklamemladidKNTVDMKENFDASLMEPEVLPAKFPNLICNGASGIAVGLSTNIPPHNFSEVAEALKYLAEFPnatveelcqfikgpdfptggilitpfeeivkiytdgrgsvtvkgkarIERLPGNRHRIIIYEIPYQVNKVElikriaelvrkgqekgisdlrdesdrdgirivvelkreadpekvlkklyrrtqlqksipinltvlvgkqpktvdlkgllqefikhrvdvitrrtlfdlekaenrlhivegllkalenadrvidivrsskdvssarsqlveefelsdtqaqaildmrlsrftalegdklyqeaddlrlkieEYQRILSSEEEKIRVFIEEIDELLEKFGDERKTVIVEEKEA----GLTFEEHYILAVLSSGRIlnRRIDDDADKKDIFQKVmNEVVSSVKPGEKLISVQEVESSIPIAFITDKGKAYWSLVADLPKGEGR---------INIDEGEIVGTAF--KGEGEEDRLFILTKNGIIKRMSYEDIFYKSQNHSI-IPLAEDDCVVTAFADDHPSLIGVYTRKGDLLLFERNQVRVTGDKAKGVEAIDLDEGDTVAGGFLINSEDLIMTVTKNGYTKLVRKEEFftkegKVKKRAQKGLMAVKLG-KDDFLSVAVPVELDETVYFSTEKGRVLKLIVDQkrIPVAKRTAMGDPVLKI-EGDYVV-----------------------------------------
>UniRef50_B7G2K9(686-1147:1165) DNA topoisomerase 2 (Fragment) n=1 Tax=Phaeodactylum tricornutum CCAP 1055/1 RepID=B7G2K9_PHATR  E=1e-103 s/c=0.82 id=23% cov=49%
-------------------------------RSIPSAIDGLKPSQRKVLYACFKRKL---KSEIKVAQLTGYCAEhtAYH-HGEASLQSTIIGMAQDFvgSNNINLLVPSGQFGTRimGGADAASPRYIYTYLAPIARSLFPEADDTLLSYLED-DGQQIEPEFYCPIIPLLVVNGCQGIGTGWSTFIPPHSANDVLEYILAKLDGAE----RLPKIHPF--------ARGFQGRIEPDPNGNGYV------SFGRSSCISDRTILIDELPLRCWTNKYKGILLKMRDRGE---VTSFVENHNTSKVSFLVTLKSAQLARMTQAGLEKSFKLKTNLQTTNMHAFnkDGQIcKFDTAESIVEAFFPVRMQLYQDRIALLQSLLNYEASILRNKAGFIKAVtSGDIDLTSGRRSKQETSKKLKEHGFLDSVELNAIKNENVLWKRRQFASEKGEGGS---NLEPMNFDYLLNMPLSSLTSEKIRELGEHAATKDKELEEMKS-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_P34030(9-227:227) DNA gyrase subunit A (Fragment) n=704 Tax=Bacteria RepID=GYRA_SPICI   E=1e-100 s/c=1.68 id=63% cov=25%
------KIRDIDIADEMKNGFLDYAMSVIVSRAIPDVRDGLKPVHRRIIYAMWDLKMTYEKQHKKSARIVGEVIGKYHPHGDTAVYEAMVRMAQDFSYRYPLIDGHGNFGSMDGDPPAAMRYTEAKMSKIAGEIIKDIEKETTIFIDNYDGSEEEPTFLPGYFPNLLVNGASGIAVGMATNIPPHNLNEVIDGVIAVTKNPEITTVELMKIIKGPDFPTG-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_UPI0001924D0A(813-1252:1315) PREDICTED: similar to DNA topoisomerase 2 n=1 Tax=Hydra magnipapillata RepID=UPI0001924D0A  E=6e-81 s/c=0.69 id=27% cov=35%
------------------------------DRSIPSMIDGFKPSQRMILYCCFKRGRHS--KEVKVSQLAGYVSENtdYH-HGEASLQGAIIGMAQNFpgSNNINILVPNGNFGYRrkGGKEHASPRYIFTELHPIANYIFREEDDEILKYNYD-DDMKVEPDVFAPIIPLGIINGSQGIGTGFSNNVPPHNPLDVVANLKRLINEKD--PVDMLPWY-----------NGFKGTIEKNPKATNKYIIRGKYCI------DGNKIHIEDIPI-VN--GWIEPYESKMEQKEDDG----------------QELQKLY--KTGVGNLDKFLNMTQSLSVTNLNMFNSKGkmtKYNSISDVLYEFYEYRLEMYQKRKEFFFLKLQNDLDI----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_P27570(665-1134:1239) DNA topoisomerase 2 n=15 Tax=Trypanosomatidae RepID=TOP2_CRIFA   E=3e-77 s/c=0.62 id=26% cov=46%
------------------------------ARAIPHCVDGLKPSQRKILWAMLKR---HSSEAAKVAQLSGYISevSSFH-HGEASLQETIVKMAQNFTggNNINLLVPEGQFGSRQqlGNDHAAPRYIFTKLSRFARLLFPEDDDPLLDYID-EEGTMVEPNHYVPILPLLLCNGAVGIGFGFATNIPSFHPLDVSAAVRAMINGESAK-QVVRNLVP---WAVGFQGTVRRGPEKEY-------IAVGKYTAHRNG-----RLHVSELPWMTSIEAFRSHISSLASSDVVQRIA---DYSGANHIDIDLIVREGSM--TTWAECETDLALSQRIYINGTVFSpDGTlsPIDADLSPVLQWHYDRRLDLYKRRRTRQIGLLEMDLARLQSTRKFVEH---------------------------FRQGHIDFLAATDDTLTKTCVKLGLVRVDDG-------YDYILKKPITFYTKTSTEKLQADIKKTQDSIAVLK--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
>UniRef50_UPI000038387A(3-362:363) COG0188: Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit n=1 Tax=Magnetospirillum magnetotacticum MS-1 RepID=UPI000038387A  E=3e-50 s/c=0.56 id=28% cov=39%
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KARLIEKLADLLQEKKLPLLADVRDESA-EDVRVVLEPRsRSVDPVMLMESLFRLSELEARVPLNLNVLVGGvVPRVIGLAEALREWVDHRRVVLQRRSTYRLGQIERRLEILGGLLIVYLDLDEVIRIIREED---EPKAALMAR----------------------------------FELTDVQANAILDTRLRSLRKLEEMELKREFDELTKEKQGIEELLGSEKLQWADITKQIRAVKKTFGPEtklgkRRTTL-ENPPDTAGIDFTARHG-RARADHGDPVREGLDPRAEGARHRPVGRLLQGRRHAEGVVPQRD-DGQDPAARLERQG----LHPRGVEAARAGpGFGDPVRLMVDLDDGTEIVAALP---YKPESKLLFAGSDGR-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
