BLASTP 2.2.22 [Sep-27-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= batch____ (242 letters) Database: uniref50.fasta 3,077,464 sequences; 1,040,396,356 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value UniRef50_D0KGP3 Silent information regulator protein Sir2 n=11 T... 396 e-109 UniRef50_B8KDE3 NAD-dependent deacetylase n=4 Tax=Gammaproteobac... 333 4e-90 UniRef50_Q9CM50 NAD-dependent deacetylase n=5 Tax=Proteobacteria... 327 3e-88 UniRef50_Q6MJJ2 NAD-dependent deacetylase n=8 Tax=Proteobacteria... 253 3e-66 UniRef50_B1LZ70 Silent information regulator protein Sir2 n=6 Ta... 228 1e-58 UniRef50_C1FAB6 Putative nicotinic acid mononucleotide:5, 6-dime... 207 2e-52 UniRef50_C6XKE4 Silent information regulator protein Sir2 n=1 Ta... 204 2e-51 UniRef50_B0VHF0 NAD-dependent deacetylase (Regulatory protein SI... 201 2e-50 UniRef50_UPI00016C4DD0 Silent information regulator protein Sir2... 197 2e-49 UniRef50_C6X5T5 NAD-dependent protein deacetylase of SIR2 family... 192 7e-48 UniRef50_D2QCS2 Silent information regulator protein Sir2 n=29 T... 192 9e-48 UniRef50_Q1D737 NAD-dependent deacetylase n=1 Tax=Myxococcus xan... 186 8e-46 UniRef50_A0LP75 Silent information regulator protein Sir2 n=3 Ta... 185 9e-46 UniRef50_C6Y0J4 Silent information regulator protein Sir2 n=1 Ta... 172 7e-42 UniRef50_Q8A3H9 NAD-dependent deacetylase n=29 Tax=Bacteria RepI... 171 2e-41 UniRef50_Q3V7G9 NAD-dependent deacetylase (Regulatory protein si... 170 3e-41 UniRef50_A9GVG5 Transcriptional regulatory protein, Sir2 family ... 169 8e-41 UniRef50_A7XXV9 Sirtuin 5 n=14 Tax=Eumetazoa RepID=A7XXV9_PIG 169 1e-40 UniRef50_D2LLI1 Silent information regulator protein Sir2 n=3 Ta... 168 1e-40 UniRef50_Q1QTH0 Silent information regulator protein Sir2 n=3 Ta... 166 7e-40 UniRef50_Q1QDL3 Silent information regulator protein Sir2 n=6 Ta... 162 7e-39 UniRef50_Q72IV5 NAD-dependent deacetylase n=8 Tax=Bacteria RepID... 162 8e-39 UniRef50_B3EMB2 Silent information regulator protein Sir2 n=2 Ta... 162 9e-39 UniRef50_C6AKY4 Transcriptional regulator, Sir2 family n=5 Tax=P... 162 9e-39 UniRef50_C6A243 NAD-dependent deacetylase n=8 Tax=Euryarchaeota ... 160 3e-38 UniRef50_Q9ZJW8 NAD-dependent deacetylase n=58 Tax=Bacteria RepI... 160 4e-38 UniRef50_UPI0001744E27 NAD-dependent protein deacetylases, SIR2 ... 159 6e-38 UniRef50_D1B334 Silent information regulator protein Sir2 n=2 Ta... 159 9e-38 UniRef50_Q9NXA8 NAD-dependent deacetylase sirtuin-5 n=37 Tax=Met... 159 1e-37 UniRef50_D2R126 Silent information regulator protein Sir2 n=1 Ta... 158 1e-37 UniRef50_A9AWG1 Silent information regulator protein Sir2 n=3 Ta... 157 2e-37 UniRef50_C7FPB6 NAD-dependent protein deacetylase n=4 Tax=enviro... 156 7e-37 UniRef50_Q2RZG2 Transcriptional regulator, Sir2 family n=2 Tax=B... 155 9e-37 UniRef50_B3QYR0 Silent information regulator protein Sir2 n=1 Ta... 153 6e-36 UniRef50_Q8R9N6 NAD-dependent deacetylase 1 n=2 Tax=Thermoanaero... 152 6e-36 UniRef50_UPI000186E50A snf2 histone linker PHD ring helicase, pu... 152 9e-36 UniRef50_C8S918 Silent information regulator protein Sir2 n=1 Ta... 149 6e-35 UniRef50_C1XSL0 NAD-dependent protein deacetylase, SIR2 family n... 148 1e-34 UniRef50_Q8Y015 NAD-dependent deacetylase n=20 Tax=cellular orga... 147 2e-34 UniRef50_Q8F3Z6 NAD-dependent deacetylase n=4 Tax=Leptospira Rep... 147 3e-34 UniRef50_Q5HU51 NAD-dependent deacetylase n=15 Tax=Campylobacter... 147 4e-34 UniRef50_C3XIH7 NAD-dependent deacetylase n=4 Tax=Campylobactera... 146 6e-34 UniRef50_B0SCR8 NAD-dependent protein deacetylase, SIR2 family n... 146 6e-34 UniRef50_A9AWT4 Silent information regulator protein Sir2 n=1 Ta... 145 1e-33 UniRef50_O30124 NAD-dependent deacetylase 2 n=18 Tax=cellular or... 145 2e-33 UniRef50_B1MER1 NAD-dependent deacetylase (Regulatory protein Si... 144 3e-33 UniRef50_C2AS85 NAD-dependent protein deacetylase, SIR2 family n... 142 8e-33 UniRef50_A9A3X3 Silent information regulator protein Sir2 n=4 Ta... 141 2e-32 UniRef50_Q88BY5 NAD-dependent deacetylase n=11 Tax=Pseudomonas R... 140 3e-32 UniRef50_D1Y076 Transcriptional regulator, Sir2 family n=1 Tax=P... 138 2e-31 UniRef50_P66814 NAD-dependent deacetylase n=12 Tax=Mycobacterium... 137 3e-31 UniRef50_B1L5P3 NAD-dependent protein deacetylase, SIR2 family n... 135 9e-31 UniRef50_B6GXN1 Pc12g08000 protein n=1 Tax=Penicillium chrysogen... 135 1e-30 UniRef50_Q46ZJ9 Silent information regulator protein Sir2 n=4 Ta... 134 3e-30 UniRef50_C1AAZ7 NAD-dependent deacetylase n=4 Tax=Bacteria RepID... 134 3e-30 UniRef50_B2VWU1 NAD-dependent deacetylase sirtuin-5 n=3 Tax=Leot... 133 4e-30 UniRef50_Q7VIN2 NAD-dependent deacetylase n=1 Tax=Helicobacter h... 133 6e-30 UniRef50_Q9I4L0 NAD-dependent deacetylase 1 n=28 Tax=Bacteria Re... 132 8e-30 UniRef50_B6KET2 NAD-dependent deacetylase, putative n=3 Tax=Toxo... 131 2e-29 UniRef50_Q6BVM7 DEHA2C01386p n=4 Tax=Saccharomycetaceae RepID=Q6... 130 3e-29 UniRef50_A9SDL4 SIR2 family protein n=2 Tax=Physcomitrella paten... 129 8e-29 UniRef50_C4QC33 Chromatin regulatory protein sir2, putative n=1 ... 129 9e-29 UniRef50_C8QW70 Silent information regulator protein Sir2 n=1 Ta... 128 1e-28 UniRef50_A5USR3 Silent information regulator protein Sir2 n=3 Ta... 128 2e-28 UniRef50_A2QWZ2 Function: human SIRT5 belongs to the Sir2-like p... 128 2e-28 UniRef50_D2VWA2 Silent information regulator family protein n=1 ... 127 3e-28 UniRef50_C7RQR7 Silent information regulator protein Sir2 n=1 Ta... 125 1e-27 UniRef50_A8NWP2 Putative uncharacterized protein n=1 Tax=Coprino... 125 1e-27 UniRef50_Q607X6 NAD-dependent deacetylase n=2 Tax=Gammaproteobac... 125 2e-27 UniRef50_A6Q178 Transcription regulator, Sir2 family n=1 Tax=Nit... 124 3e-27 UniRef50_Q6C8C7 YALI0D20724p n=1 Tax=Yarrowia lipolytica RepID=Q... 122 1e-26 UniRef50_C5AIV3 Putative uncharacterized protein n=1 Tax=Burkhol... 122 1e-26 UniRef50_D0LVG3 Silent information regulator protein Sir2 n=1 Ta... 122 1e-26 UniRef50_C5CY53 Silent information regulator protein Sir2 n=1 Ta... 121 2e-26 UniRef50_Q8NSM4 NAD-dependent deacetylase n=15 Tax=Corynebacteri... 121 2e-26 UniRef50_A8MBU4 NAD-dependent deacetylase n=14 Tax=cellular orga... 120 3e-26 UniRef50_B2ARI4 Predicted CDS Pa_4_7390 (Fragment) n=1 Tax=Podos... 120 3e-26 UniRef50_A9DQY7 Silent information regulator protein Sir2 n=1 Ta... 120 5e-26 UniRef50_B8F955 Silent information regulator protein Sir2 n=1 Ta... 120 6e-26 UniRef50_A8VRI8 NAD-dependent protein deacetylase SIR2 family-li... 119 7e-26 UniRef50_Q5WKC8 NAD-dependent deacetylase n=7 Tax=Bacillaceae Re... 119 1e-25 UniRef50_B8JAI9 Silent information regulator protein Sir2 n=5 Ta... 119 1e-25 UniRef50_B0D7T5 Predicted protein n=3 Tax=Agaricales RepID=B0D7T... 117 4e-25 UniRef50_A3LRA1 Transcriptional regulatory protein n=4 Tax=Sacch... 117 4e-25 UniRef50_Q8ZU41 NAD-dependent deacetylase 1 n=4 Tax=Pyrobaculum ... 116 6e-25 UniRef50_Q75DM1 ABL004Wp n=1 Tax=Eremothecium gossypii RepID=Q75... 116 6e-25 UniRef50_Q2YZT2 Putative uncharacterized protein n=1 Tax=uncultu... 115 1e-24 UniRef50_A6LP94 Silent information regulator protein Sir2 n=1 Ta... 115 1e-24 UniRef50_A9A0B2 NAD-dependent deacetylase n=1 Tax=Desulfococcus ... 115 2e-24 UniRef50_A1ZHW6 NAD-dependent deacetylase n=2 Tax=Microscilla ma... 115 2e-24 UniRef50_C5L233 NAD-dependent deacetylase sirtuin-5, putative n=... 115 2e-24 UniRef50_C4DIV4 NAD-dependent protein deacetylase, SIR2 family n... 115 2e-24 UniRef50_C5GPX3 SIR2 family histone deacetylase n=2 Tax=Ajellomy... 114 3e-24 UniRef50_B9L9A0 NAD-dependent deacetylase n=4 Tax=Bacteria RepID... 113 6e-24 UniRef50_A4J646 Silent information regulator protein Sir2 n=2 Ta... 112 8e-24 UniRef50_A0LG97 Silent information regulator protein Sir2 n=1 Ta... 112 1e-23 UniRef50_B7IF48 NAD-dependent deacetylase n=1 Tax=Thermosipho af... 112 1e-23 UniRef50_A6DC77 Silent information regulator protein Sir2 n=1 Ta... 111 2e-23 UniRef50_D1A1X3 Silent information regulator protein Sir2 n=13 T... 111 2e-23 UniRef50_C6BY08 Silent information regulator protein Sir2 n=1 Ta... 111 2e-23 UniRef50_D1UAS5 Silent information regulator protein Sir2 n=1 Ta... 110 3e-23 UniRef50_Q0AY57 Regulatory protein, sir2 family n=1 Tax=Syntroph... 110 3e-23 UniRef50_C8X5T0 Silent information regulator protein Sir2 n=3 Ta... 110 4e-23 UniRef50_C0QHD0 NpdA n=1 Tax=Desulfobacterium autotrophicum HRM2... 110 6e-23 UniRef50_D2RNB5 Silent information regulator protein Sir2 n=1 Ta... 110 6e-23 UniRef50_C0GT54 Silent information regulator protein Sir2 n=1 Ta... 109 7e-23 UniRef50_A9AZF2 Silent information regulator protein Sir2 n=1 Ta... 107 2e-22 UniRef50_A1ZPG8 NAD-dependent deacetylase n=1 Tax=Microscilla ma... 107 3e-22 UniRef50_C3WP91 SIR2 family protein n=9 Tax=Fusobacterium RepID=... 107 3e-22 UniRef50_C9STC7 NAD-dependent deacetylase sirtuin-5 n=5 Tax=Sord... 107 5e-22 UniRef50_B0EU66 NAD-dependent deacetylase, putative n=2 Tax=Enta... 106 6e-22 UniRef50_C9R9I3 Silent information regulator protein Sir2 n=1 Ta... 106 8e-22 UniRef50_B8FEP4 Silent information regulator protein Sir2 n=1 Ta... 106 8e-22 UniRef50_Q89LY4 NAD-dependent deacetylase 1 n=18 Tax=Proteobacte... 105 1e-21 UniRef50_A8NIK3 Putative uncharacterized protein n=1 Tax=Coprino... 105 1e-21 UniRef50_Q5L014 NAD-dependent deacetylase 1 n=8 Tax=Firmicutes R... 105 1e-21 UniRef50_C4FX59 Putative uncharacterized protein n=1 Tax=Catonel... 105 2e-21 UniRef50_B5YJW3 NAD-dependent deacetylase n=1 Tax=Thermodesulfov... 104 2e-21 UniRef50_C4GC77 Putative uncharacterized protein n=3 Tax=Clostri... 104 2e-21 UniRef50_C6CZ67 Silent information regulator protein Sir2 n=1 Ta... 104 3e-21 UniRef50_Q8CJM9 NAD-dependent deacetylase 2 n=8 Tax=Actinomyceta... 103 4e-21 UniRef50_O07595 NAD-dependent deacetylase n=5 Tax=Bacillus RepID... 103 5e-21 UniRef50_A9NEY3 Putative uncharacterized protein n=1 Tax=Acholep... 103 6e-21 UniRef50_Q5BVX8 SJCHGC08739 protein (Fragment) n=1 Tax=Schistoso... 103 6e-21 UniRef50_C3IUP0 SIR2 n=2 Tax=Bacillus thuringiensis RepID=C3IUP0... 102 8e-21 UniRef50_B9E751 Putative uncharacterized protein n=1 Tax=Macroco... 102 1e-20 UniRef50_Q2LSF2 Sir2 family of NAD+-dependent deacetylase n=2 Ta... 101 2e-20 UniRef50_D0WS10 NAD-dependent deacetylase n=2 Tax=Actinomyces Re... 101 2e-20 UniRef50_Q97MB4 NAD-dependent deacetylase n=71 Tax=cellular orga... 101 2e-20 UniRef50_Q899G3 NAD-dependent deacetylase n=52 Tax=Bacteria RepI... 101 3e-20 UniRef50_A7HL19 Silent information regulator protein Sir2 n=1 Ta... 100 5e-20 UniRef50_Q0CI01 Putative uncharacterized protein n=2 Tax=Leotiom... 100 7e-20 UniRef50_Q8REC3 NAD-dependent deacetylase n=8 Tax=Fusobacterium ... 100 7e-20 UniRef50_Q81BT4 NAD-dependent deacetylase n=75 Tax=Bacillus RepI... 99 1e-19 UniRef50_C1ZIT2 NAD-dependent protein deacetylase, SIR2 family n... 99 1e-19 UniRef50_D1B8J6 Silent information regulator protein Sir2 n=1 Ta... 99 1e-19 UniRef50_Q9WYW0 NAD-dependent deacetylase n=5 Tax=Thermotogaceae... 99 1e-19 UniRef50_C7MBX0 NAD-dependent protein deacetylase, SIR2 family n... 99 1e-19 UniRef50_Q6WIA8 Sir2/CobB protein n=1 Tax=Vibrio phage KVP40 Rep... 97 4e-19 UniRef50_B5Y820 Putative NAD-dependent deacetylase 2 n=1 Tax=Cop... 97 7e-19 UniRef50_C4R311 NAD(+)-dependent histone deacetylase n=3 Tax=Sac... 96 7e-19 UniRef50_C6P8W9 Silent information regulator protein Sir2 n=2 Ta... 96 7e-19 UniRef50_A6TNA0 Silent information regulator protein Sir2 n=2 Ta... 96 8e-19 UniRef50_B0S0T6 Transcriptional regulator Sir2 family n=4 Tax=Cl... 96 9e-19 UniRef50_C0S043 NAD-dependent deacetylase n=5 Tax=Onygenales Rep... 96 9e-19 UniRef50_B3L8U3 Transcriptional regulatory protein sir2 homologu... 96 1e-18 UniRef50_Q8CNF4 NAD-dependent deacetylase n=64 Tax=Staphylococcu... 96 1e-18 UniRef50_Q47EY8 Silent information regulator protein Sir2 n=7 Ta... 96 2e-18 UniRef50_B0EBU9 NAD-dependent deacetylase, putative n=3 Tax=Enta... 95 2e-18 UniRef50_A7SK95 Predicted protein n=1 Tax=Nematostella vectensis... 94 3e-18 UniRef50_Q4ZNC3 Silent information regulator protein Sir2 n=1 Ta... 94 4e-18 UniRef50_Q73KE1 NAD-dependent deacetylase n=2 Tax=Treponema RepI... 94 4e-18 UniRef50_B3T8H4 Putative Sir2 family protein n=1 Tax=uncultured ... 94 5e-18 UniRef50_B4VCV9 SIR2 family transcriptional regulator n=3 Tax=Ac... 93 6e-18 UniRef50_Q67KQ0 NAD-dependent deacetylase n=1 Tax=Symbiobacteriu... 93 7e-18 UniRef50_B2A496 Silent information regulator protein Sir2 n=1 Ta... 93 8e-18 UniRef50_C4XFR7 Putative uncharacterized protein n=1 Tax=Mycopla... 93 8e-18 UniRef50_B1MX21 NAD-dependent protein deacetylase, SIR2 family n... 93 9e-18 UniRef50_C1VAT1 NAD-dependent protein deacetylase, SIR2 family n... 93 9e-18 UniRef50_C5CGD1 Silent information regulator protein Sir2 n=3 Ta... 92 1e-17 UniRef50_Q5V4Q5 NAD-dependent deacetylase n=3 Tax=Halobacteriace... 92 2e-17 UniRef50_D2Q7L2 SIR2 family protein n=13 Tax=Bifidobacterium Rep... 92 2e-17 UniRef50_B1I1N5 Silent information regulator protein Sir2 n=1 Ta... 91 2e-17 UniRef50_D2RCH9 Transcriptional regulator, Sir2 family n=7 Tax=B... 91 4e-17 UniRef50_UPI0001C3128D Silent information regulator protein Sir2... 91 5e-17 UniRef50_C5DRF3 ZYRO0B08008p n=1 Tax=Zygosaccharomyces rouxii Re... 90 5e-17 UniRef50_A5UYK2 Silent information regulator protein Sir2 n=2 Ta... 89 9e-17 UniRef50_A0NQ49 Silent information regulator protein Sir2 n=2 Ta... 89 9e-17 UniRef50_C1SNI0 NAD-dependent protein deacetylase, SIR2 family n... 89 1e-16 UniRef50_C8W9D8 Silent information regulator protein Sir2 n=2 Ta... 89 2e-16 UniRef50_Q5KZE8 NAD-dependent deacetylase 2 n=8 Tax=Bacteria Rep... 88 2e-16 UniRef50_Q8R984 NAD-dependent deacetylase 2 n=9 Tax=Thermoanaero... 88 2e-16 UniRef50_C2H995 NAD-dependent deacetylase (SIR2 family regulator... 88 2e-16 UniRef50_D1N1D6 Silent information regulator protein Sir2 n=1 Ta... 87 4e-16 UniRef50_Q839C6 NAD-dependent deacetylase n=22 Tax=Bacilli RepID... 87 5e-16 UniRef50_D2RWQ5 Silent information regulator protein Sir2 n=2 Ta... 87 5e-16 UniRef50_Q6QGI5 NAD-dependent protein deacetylases SIR2 family n... 87 7e-16 UniRef50_Q71W25 NAD-dependent deacetylase n=32 Tax=Bacilli RepID... 87 7e-16 UniRef50_C0W513 NAD-dependent deacetylase 1 n=4 Tax=Actinomyceta... 86 8e-16 UniRef50_Q12Y78 NAD-dependent deacetylase, Sir2-like n=1 Tax=Met... 86 1e-15 UniRef50_C0GF21 Silent information regulator protein Sir2 n=1 Ta... 86 1e-15 UniRef50_Q3A6W7 NAD-dependent protein deacetylases, SIR2 family ... 86 1e-15 UniRef50_B8LYM0 SIR2 family histone deacetylase, putative n=17 T... 86 2e-15 UniRef50_D2S8Y6 Silent information regulator protein Sir2 n=1 Ta... 85 2e-15 UniRef50_C5DBK2 KLTH0A03300p n=1 Tax=Lachancea thermotolerans CB... 85 3e-15 UniRef50_B3WAV7 NAD-dependent deacetylase (Regulatory protein SI... 85 3e-15 UniRef50_B9L4G7 NAD-dependent deacetylase 1 (Regulatory protein ... 84 4e-15 UniRef50_C2C3V6 NAD-dependent deacetylase (Regulatory protein SI... 84 6e-15 UniRef50_Q9Y6E7 NAD-dependent ADP-ribosyltransferase sirtuin-4 n... 84 6e-15 UniRef50_A0C6J0 Chromosome undetermined scaffold_152, whole geno... 83 7e-15 UniRef50_UPI0001742E98 NAD-dependent deacetylase n=1 Tax=candida... 82 1e-14 UniRef50_C7TMK6 NAD-dependent protein deacetylase, SIR2 family n... 82 1e-14 UniRef50_A9BHU8 Silent information regulator protein Sir2 n=3 Ta... 82 2e-14 UniRef50_C1DBX3 NAD-dependent deacetylase n=1 Tax=Laribacter hon... 82 2e-14 UniRef50_Q9I4E1 NAD-dependent deacetylase 2 n=6 Tax=Pseudomonas ... 82 2e-14 UniRef50_UPI00019255E8 PREDICTED: similar to sirtuin n=2 Tax=Hyd... 82 2e-14 UniRef50_C3YDA2 Putative uncharacterized protein n=1 Tax=Branchi... 80 6e-14 UniRef50_C9M9P4 Transcriptional regulator, Sir2 family n=1 Tax=J... 80 7e-14 UniRef50_A3ZMQ7 Sir2 family, possible ADP ribosyltransferase n=1... 79 9e-14 UniRef50_D2NR35 NAD-dependent protein deacetylase n=2 Tax=Rothia... 79 1e-13 UniRef50_Q885X7 NAD-dependent deacetylase 2 n=9 Tax=Pseudomonada... 79 1e-13 UniRef50_Q21921 NAD-dependent deacetylase SIR2 homolog n=2 Tax=C... 79 1e-13 UniRef50_A0Z2E4 NAD-dependent deacetylase n=3 Tax=unclassified G... 79 2e-13 UniRef50_Q5GUM2 SIR2-like regulatory protein n=5 Tax=cellular or... 79 2e-13 UniRef50_Q07FY7 Sirtuin (Silent mating type information regulati... 78 2e-13 UniRef50_Q1YSP9 NAD-dependent deacetylase n=1 Tax=gamma proteoba... 77 3e-13 UniRef50_A4VDQ9 Chromatin regulatory protein sir2 n=1 Tax=Tetrah... 77 4e-13 UniRef50_Q6C219 YALI0F11583p n=1 Tax=Yarrowia lipolytica RepID=Q... 77 4e-13 UniRef50_C4WX51 ACYPI009170 protein n=1 Tax=Acyrthosiphon pisum ... 77 5e-13 UniRef50_A1U4N6 Silent information regulator protein Sir2 n=2 Ta... 76 8e-13 UniRef50_A2DP91 Transcriptional regulator, Sir2 family protein n... 75 1e-12 UniRef50_Q8FUC8 NAD-dependent deacetylase 1 n=11 Tax=Corynebacte... 75 2e-12 UniRef50_Q96EB6 NAD-dependent deacetylase sirtuin-1 n=36 Tax=Eut... 75 2e-12 UniRef50_Q4UZX0 NAD-dependent deacetylase n=94 Tax=Bacteria RepI... 75 2e-12 UniRef50_D2A3P1 Putative uncharacterized protein GLEAN_14968 n=1... 75 2e-12 UniRef50_A5DW75 Putative uncharacterized protein n=1 Tax=Loddero... 75 2e-12 UniRef50_C1SL47 NAD-dependent protein deacetylase, SIR2 family n... 74 4e-12 UniRef50_C5CCZ4 NAD-dependent protein deacetylase, SIR2 family n... 74 6e-12 UniRef50_A8PZF9 NAD-dependent deacetylase SIRT1, putative n=1 Ta... 73 7e-12 UniRef50_UPI000179269F PREDICTED: similar to sirtuin n=1 Tax=Acy... 73 8e-12 UniRef50_Q1RPU3 Zinc finger protein (Fragment) n=1 Tax=Ciona int... 72 2e-11 UniRef50_B0MPR9 Putative uncharacterized protein n=1 Tax=Eubacte... 72 2e-11 UniRef50_Q5CYK0 Bacterial-like Sir2 family protein (Fragment) n=... 71 3e-11 UniRef50_A8NVB6 Putative uncharacterized protein n=1 Tax=Coprino... 71 4e-11 UniRef50_A0DQW0 Chromosome undetermined scaffold_6, whole genome... 70 5e-11 UniRef50_UPI0001925E2D PREDICTED: similar to NAD-dependent deace... 70 5e-11 UniRef50_Q55PY8 Putative uncharacterized protein n=2 Tax=Filobas... 70 6e-11 UniRef50_A1HU63 Silent information regulator protein Sir2 n=1 Ta... 70 6e-11 UniRef50_Q9NTG7 NAD-dependent deacetylase sirtuin-3, mitochondri... 70 7e-11 UniRef50_A7XPL0 Sirtuin 4 (Fragment) n=9 Tax=Coelomata RepID=A7X... 70 8e-11 UniRef50_D1MN70 Protein F46G10.7c, confirmed by transcript evide... 70 8e-11 UniRef50_C7MA66 NAD-dependent protein deacetylase, SIR2 family n... 70 8e-11 UniRef50_C5M5U2 NAD-dependent histone deacetylase SIR2 n=2 Tax=C... 70 9e-11 UniRef50_A7H2V7 NAD-dependent deacetylase n=1 Tax=Campylobacter ... 69 9e-11 UniRef50_D2VK77 Putative uncharacterized protein n=1 Tax=Naegler... 69 1e-10 UniRef50_A4A980 NAD-dependent deacetylase n=6 Tax=Gammaproteobac... 69 1e-10 UniRef50_A4QUX8 Putative uncharacterized protein n=1 Tax=Magnapo... 69 1e-10 UniRef50_C4Q5J6 Chromatin regulatory protein sir2, putative n=2 ... 69 1e-10 UniRef50_D1VJM1 Silent information regulator protein Sir2 n=1 Ta... 69 1e-10 UniRef50_Q882K4 NAD-dependent deacetylase 3 n=7 Tax=Pseudomonas ... 69 2e-10 UniRef50_D2VCI1 Silent information regulator family protein n=2 ... 69 2e-10 UniRef50_Q54LF0 Ankyrin repeat-containing protein n=1 Tax=Dictyo... 69 2e-10 UniRef50_D0R2Y5 NAD-dependent deacetylase n=16 Tax=Lactobacillus... 69 2e-10 UniRef50_UPI000051AA14 PREDICTED: similar to NAD-dependent deace... 69 2e-10 UniRef50_B3S4A5 Putative uncharacterized protein n=1 Tax=Trichop... 68 3e-10 UniRef50_C8WXB4 Silent information regulator protein Sir2 n=2 Ta... 68 3e-10 UniRef50_D2Q1M5 Silent information regulator protein Sir2 n=7 Ta... 68 3e-10 UniRef50_C7TJ15 Silent information regulator protein Sir2 n=4 Ta... 68 3e-10 UniRef50_D1ZEY9 Whole genome shotgun sequence assembly, scaffold... 67 3e-10 UniRef50_B9GC62 Putative uncharacterized protein n=1 Tax=Oryza s... 67 4e-10 >UniRef50_D0KGP3 Silent information regulator protein Sir2 n=11 Tax=Proteobacteria RepID=D0KGP3_PECWW Length = 276 Score = 396 bits (1018), Expect = e-109, Method: Compositional matrix adjust. Identities = 187/229 (81%), Positives = 203/229 (88%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 M+KPRV+VLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGF RDPELVQ FYNARRR Sbjct: 36 MKKPRVVVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFQRDPELVQEFYNARRR 95 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 QLQQPEI PNAAHLALA L+ L D F L+TQNIDNLHERAG+ VIHMHGELLK+RCSQ Sbjct: 96 QLQQPEIVPNAAHLALANLEAMLEDNFQLITQNIDNLHERAGSRRVIHMHGELLKIRCSQ 155 Query: 121 SGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSG 180 SGQ+ +WT D+ ++CHCCQFPAPLRPHVVWFGEMPL MD+IY ALS AD FIAIGTSG Sbjct: 156 SGQIFEWTDDLAAGERCHCCQFPAPLRPHVVWFGEMPLHMDKIYHALSQADYFIAIGTSG 215 Query: 181 HVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFV 229 HVYPAAGFVHEA HGA+T+ELNLEPSQV ++F EK YGPAS VVPEFV Sbjct: 216 HVYPAAGFVHEAHSHGAYTLELNLEPSQVESQFDEKIYGPASAVVPEFV 264 >UniRef50_B8KDE3 NAD-dependent deacetylase n=4 Tax=Gammaproteobacteria RepID=B8KDE3_VIBPA Length = 245 Score = 333 bits (853), Expect = 4e-90, Method: Compositional matrix adjust. Identities = 154/228 (67%), Positives = 187/228 (82%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQP 65 V++LTGAGISAESGI+TFRA DGLWE+HR+EDVATPEGF RDP+LVQ FYN RR LQ+P Sbjct: 8 VVILTGAGISAESGIQTFRAQDGLWEDHRIEDVATPEGFARDPDLVQDFYNKRRIMLQEP 67 Query: 66 EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVL 125 I+PNAAH+AL +L+ L ++TQNIDNLHER G++NVIHMHGELLK RCS S QV+ Sbjct: 68 HIEPNAAHIALGQLEAELDGTVTVITQNIDNLHERGGSSNVIHMHGELLKARCSVSNQVV 127 Query: 126 DWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGHVYPA 185 + G++ D CHCCQ P+ +RPHVVWFGEMPL M EIY +L AD+FI+IGTSG V+PA Sbjct: 128 EELGEIKTGDLCHCCQMPSQMRPHVVWFGEMPLRMGEIYQSLEDADLFISIGTSGVVFPA 187 Query: 186 AGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLL 233 AGFVH+AK+HGAHT+E+NLEPS V +EF EK YG AS VP+ VE++L Sbjct: 188 AGFVHDAKMHGAHTIEINLEPSAVESEFEEKRYGKASVEVPKLVEEIL 235 >UniRef50_Q9CM50 NAD-dependent deacetylase n=5 Tax=Proteobacteria RepID=NPD_PASMU Length = 234 Score = 327 bits (837), Expect = 3e-88, Method: Compositional matrix adjust. Identities = 152/229 (66%), Positives = 184/229 (80%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQ 64 R++VLTGAGISAESGIRTFRA DGLWE H V++VATPEGF R+P+LVQ FYN RR+QL Sbjct: 6 RIVVLTGAGISAESGIRTFRATDGLWENHPVDEVATPEGFARNPKLVQRFYNERRKQLFS 65 Query: 65 PEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQV 124 +I PNAAH ALA+L+ LGD L+VTQN+DNLHERAG+ N+IHMHGELLKVRC +SG++ Sbjct: 66 DQIAPNAAHFALAELEKKLGDNLLIVTQNVDNLHERAGSKNLIHMHGELLKVRCVKSGKI 125 Query: 125 LDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGHVYP 184 DW GD+ DKC CC LRPH+VWFGEMPL M++I ALS D FI+IGTSG+VYP Sbjct: 126 YDWQGDIGEHDKCLCCTPTQILRPHIVWFGEMPLEMEKIQTALSECDYFISIGTSGNVYP 185 Query: 185 AAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLL 233 AAGFV EA +GAHTVELNLEPSQV + F E +YG A+++VP ++ + L Sbjct: 186 AAGFVREALFYGAHTVELNLEPSQVRSSFDECHYGKATELVPHYLAQFL 234 >UniRef50_Q6MJJ2 NAD-dependent deacetylase n=8 Tax=Proteobacteria RepID=NPD_BDEBA Length = 235 Score = 253 bits (647), Expect = 3e-66, Method: Compositional matrix adjust. Identities = 124/229 (54%), Positives = 158/229 (68%), Gaps = 2/229 (0%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQP 65 +++LTGAGISAESGIRTFR DGLWE+HR+EDVATPE F R+P LVQ FYN RR QL+ P Sbjct: 9 IVILTGAGISAESGIRTFRDQDGLWEDHRIEDVATPEAFARNPALVQRFYNLRRAQLRDP 68 Query: 66 EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVL 125 + PN AH AL L++ FLLVTQN+DNLH RAG+ N++HMHG L +V C + Sbjct: 69 NLAPNPAHQALVDLENLWEGNFLLVTQNVDNLHRRAGSKNLLHMHGRLDRVFCLHCDEHF 128 Query: 126 DWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGHVYPA 185 +W D+ + C C +RP +VWFGEMP M+EIY AL AD FI+IGTSG+VYPA Sbjct: 129 EWLLDLAVDQPCPHCGRKGGVRPDIVWFGEMPHHMEEIYEALDKADYFISIGTSGNVYPA 188 Query: 186 AGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLK 234 AGFV A A +E+NL+ +++ F E + GPAS VP F+ + L+ Sbjct: 189 AGFVRLA--WKAKKIEINLKDTEISPAFDEHFVGPASTEVPRFITQFLE 235 >UniRef50_B1LZ70 Silent information regulator protein Sir2 n=6 Tax=Alphaproteobacteria RepID=B1LZ70_METRJ Length = 237 Score = 228 bits (581), Expect = 1e-58, Method: Compositional matrix adjust. Identities = 115/235 (48%), Positives = 150/235 (63%), Gaps = 6/235 (2%) Query: 2 EKPR-VLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 + PR + VLTGAG+SAESG+ TFR G+W +ATPE + DP+ V FY+ RRR Sbjct: 3 DHPRTIFVLTGAGVSAESGLGTFRDRGGIWARFDPMKLATPEAYAADPDTVLDFYDHRRR 62 Query: 61 QLQQPEIQPNAAHLALAKLQD---ALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVR 117 + E PNAAH ALA+ + A G R L TQN+D+LHERAG+ + HMHGELLK R Sbjct: 63 GVVAAE--PNAAHRALARAETRIAARGGRLFLCTQNVDDLHERAGSRAITHMHGELLKAR 120 Query: 118 CSQSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIG 177 C V W D++ D C C +RP VVWFGEMP+ +D I AL+ AD+F+A+G Sbjct: 121 CCACTAVTPWRADLSRADSCPACGAAGRMRPDVVWFGEMPMHLDAIEAALAEADLFVAVG 180 Query: 178 TSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 TSG VYPAAG+V +A+ G T E+NLEPS + F + YGPAS +P ++ +L Sbjct: 181 TSGAVYPAAGYVRQARALGIPTCEVNLEPSDNADAFDDARYGPASAALPRYLAEL 235 >UniRef50_C1FAB6 Putative nicotinic acid mononucleotide:5, 6-dimethylbenzimidazole(DMB)phosphoribosyltransferase n=1 Tax=Acidobacterium capsulatum ATCC 51196 RepID=C1FAB6_ACIC5 Length = 250 Score = 207 bits (527), Expect = 2e-52, Method: Compositional matrix adjust. Identities = 110/228 (48%), Positives = 144/228 (63%), Gaps = 13/228 (5%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQ 64 R+ VLTGAGISAESG+ TFR +DGLW +RVE+VATPEG+ +PELV FY+ RRR Sbjct: 15 RLFVLTGAGISAESGLATFRGSDGLWNGYRVEEVATPEGWAENPELVWRFYSMRRRDALA 74 Query: 65 PEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQ- 123 E PNAAH+ALA+L++ +G+RF L TQN+D+LHERAG+ V HMHG L RC + Q Sbjct: 75 AE--PNAAHVALARLEERMGERFYLCTQNVDDLHERAGSRRVHHMHGTLFCSRCVRCQQP 132 Query: 124 -----VLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGT 178 + G++ ++C + +RPH+VWFGE+P MD IY L A + + +GT Sbjct: 133 FADARFYETAGELPVCERCG-----SAVRPHIVWFGEIPRDMDGIYRELEQATVLLVVGT 187 Query: 179 SGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVP 226 SG VYPAAG V A+ G TV + E F E G A +V+P Sbjct: 188 SGSVYPAAGLVQVARQRGIATVYVGPERPLNAQAFGEIRLGTAVEVLP 235 >UniRef50_C6XKE4 Silent information regulator protein Sir2 n=1 Tax=Hirschia baltica ATCC 49814 RepID=C6XKE4_HIRBI Length = 249 Score = 204 bits (520), Expect = 2e-51, Method: Compositional matrix adjust. Identities = 104/233 (44%), Positives = 143/233 (61%), Gaps = 5/233 (2%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQP 65 V++LTGAG+S ESGI +R D +W +E+ P+ F ++PELV FYN RR L++ Sbjct: 9 VVLLTGAGVSVESGIPVYRNEDEIWTRKEMENFFRPDTFRKNPELVHDFYNKRRMDLKK- 67 Query: 66 EIQPNAAHLALAKLQDAL-GDR--FLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG 122 IQPN H +A LQD L G R ++T+N+D+LHE+AG T+VIH+ G+L C+ Sbjct: 68 -IQPNKTHCHIAYLQDQLLGSRTKLTIITKNVDDLHEKAGTTDVIHILGDLNSAFCTICN 126 Query: 123 QVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGHV 182 + GD+ + C C+ +RP +VW GE P MD+I AL D+F++IGTSG V Sbjct: 127 IRIKCMGDLITQTICSNCKNKKTMRPDIVWAGEKPYHMDKIQAALDECDLFVSIGTSGSV 186 Query: 183 YPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKG 235 YP A FV+ AK GA TVELN +PS F YGPAS +VP +V+ + G Sbjct: 187 YPTADFVNLAKKTGAVTVELNQKPSANATSFDHTNYGPASTIVPFWVDTFIHG 239 >UniRef50_B0VHF0 NAD-dependent deacetylase (Regulatory protein SIR2 homolog) n=1 Tax=Candidatus Cloacamonas acidaminovorans RepID=B0VHF0_9BACT Length = 237 Score = 201 bits (511), Expect = 2e-50, Method: Compositional matrix adjust. Identities = 115/227 (50%), Positives = 139/227 (61%), Gaps = 6/227 (2%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQ 64 VLVLTGAGISAESGIRTFR + GLWE HRVEDVATPE F+ +P V FY R+R Sbjct: 9 NVLVLTGAGISAESGIRTFRDSGGLWENHRVEDVATPEAFNSNPVKVWEFY--RQRYQDS 66 Query: 65 PEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQV 124 +PN AHLAL KL+ LGD FLLVTQN+D LH +AG+ V+ MHG L C++ Sbjct: 67 ISSKPNPAHLALVKLEQFLGDNFLLVTQNVDCLHIKAGSKRVLEMHGSLANCICTKCHSK 126 Query: 125 LDWTG-DVT-PEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGHV 182 L D+T P C C LRP +VWFGE+P ++ I AL +FI +GTSG V Sbjct: 127 LAIKDIDLTQPIPLCPFCN--GILRPDIVWFGEIPHYLNIIDDALRKCSVFIIVGTSGVV 184 Query: 183 YPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFV 229 YPAAGFV AKL GA T+ +NL E Y G + ++P V Sbjct: 185 YPAAGFVLTAKLMGAKTIAINLGKPDNLAYIDEFYQGKSGDILPGLV 231 >UniRef50_UPI00016C4DD0 Silent information regulator protein Sir2 n=1 Tax=Gemmata obscuriglobus UQM 2246 RepID=UPI00016C4DD0 Length = 249 Score = 197 bits (502), Expect = 2e-49, Method: Compositional matrix adjust. Identities = 107/236 (45%), Positives = 148/236 (62%), Gaps = 19/236 (8%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQP 65 V VLTGAGISAESG+ TFRA+DGLWE HR+EDVA+P+G+DR+P LV FYNARR + Sbjct: 23 VCVLTGAGISAESGVPTFRASDGLWEGHRIEDVASPDGWDRNPALVWQFYNARRANVAT- 81 Query: 66 EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQV- 124 ++PN H AL L+D GD F LVTQN+D LH +AG+ V+ +HG L + RC+ V Sbjct: 82 -VKPNPGHFALVALEDRFGDNFKLVTQNVDGLHLQAGSRRVLEIHGSLRQTRCTVCEAVT 140 Query: 125 ---LDWTGDVTPEDKCHCCQFPAPLRPHVVWFGE-MPLGMDEIYM----ALSMADIFIAI 176 L+ GD +CH LRPH+VWFGE +P D+I+M + S D + + Sbjct: 141 NRGLEPLGDAPECPQCH-----GRLRPHIVWFGEGLP---DDIWMEAMVSASECDTLLVV 192 Query: 177 GTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 GTS V+PAA V A+ GA +E+N+ ++ YGP+ +V+P+ +++L Sbjct: 193 GTSAVVHPAASLVPIARRKGATVIEVNITRTEASAYADIGLYGPSGEVLPKLLQRL 248 >UniRef50_C6X5T5 NAD-dependent protein deacetylase of SIR2 family n=1 Tax=Flavobacteriaceae bacterium 3519-10 RepID=C6X5T5_FLAB3 Length = 230 Score = 192 bits (489), Expect = 7e-48, Method: Compositional matrix adjust. Identities = 99/188 (52%), Positives = 127/188 (67%), Gaps = 8/188 (4%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 + +++VL+GAG SAESG++TFR +DGLWE HR+EDVA+PEGF R+P+ V FYNARRRQL Sbjct: 4 RKKLVVLSGAGSSAESGVQTFRDSDGLWENHRIEDVASPEGFARNPQFVLDFYNARRRQL 63 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS- 121 +QPN AH LAKLQD L +++TQN+D+LHE+AG+ NVIH+HGEL K R S Sbjct: 64 DL--VQPNDAHRILAKLQDVL--EVVIITQNVDDLHEKAGSQNVIHLHGELRKARPVDSL 119 Query: 122 GQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGH 181 + W D+ D + LRPH+VWFGEM M+ AD F+ +GTS Sbjct: 120 TDIRIWNKDLNIGD---LAEDGTQLRPHIVWFGEMVPEMERAVETAQTADYFLIVGTSMQ 176 Query: 182 VYPAAGFV 189 VYPAAG V Sbjct: 177 VYPAAGLV 184 >UniRef50_D2QCS2 Silent information regulator protein Sir2 n=29 Tax=Bacteria RepID=D2QCS2_9SPHI Length = 235 Score = 192 bits (488), Expect = 9e-48, Method: Compositional matrix adjust. Identities = 106/236 (44%), Positives = 143/236 (60%), Gaps = 34/236 (14%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 + +++VL+GAGISAESGI TFRA+DGLWE HR+EDVATPE + R+P LVQ FYN RR+Q Sbjct: 4 RKKIVVLSGAGISAESGIPTFRASDGLWENHRIEDVATPEAWHRNPALVQDFYNQRRKQA 63 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG 122 +QPNA HLAL KL++ ++TQN+DNLHE+AG++ V+H+HGEL K R + Sbjct: 64 LS--VQPNAGHLALVKLEEKFD--VTVITQNVDNLHEKAGSSKVVHLHGELFKSRSTVDE 119 Query: 123 QVL----DW---TGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIA 175 ++ W GDV C + LRPH+VWFGE MD AD+FI Sbjct: 120 SLIYDIEGWELKDGDV--------CAKGSQLRPHIVWFGEAVPMMDIALDITEQADLFIV 171 Query: 176 IGTSGHVYPAAGFVHEAK--------------LHGAHTVELNLEPSQVG-NEFAEK 216 +GTS +VYPAAG V+ + +H + V EP+ +G + AE+ Sbjct: 172 VGTSLNVYPAAGLVYAVREGVPVYVVDPSIPDMHKKNNVTFIAEPATIGLTQLAEQ 227 >UniRef50_Q1D737 NAD-dependent deacetylase n=1 Tax=Myxococcus xanthus DK 1622 RepID=Q1D737_MYXXD Length = 245 Score = 186 bits (471), Expect = 8e-46, Method: Compositional matrix adjust. Identities = 105/236 (44%), Positives = 137/236 (58%), Gaps = 15/236 (6%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQP 65 +LVLTGAG+SAESG+ TFR GLWE+ VE VA+PEGF +DP LV FY+ RR+ Sbjct: 12 LLVLTGAGVSAESGVPTFRGMSGLWEDQPVEAVASPEGFRKDPALVWRFYSERRKAAAA- 70 Query: 66 EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVL 125 + PN H AL + LGDRFLL TQN+D LH RAG+ V+ MHG L K RCS+ G+ Sbjct: 71 -VHPNPGHEALVAWERHLGDRFLLATQNVDGLHTRAGSQRVVEMHGNLFKTRCSRCGRPP 129 Query: 126 DWTGDVTPED---KCHCCQFPAPLRPHVVWFGEM--PLGMDEIY-MALSMAD-----IFI 174 V P +C C LRPH+VWFGE P + I +L A +F+ Sbjct: 130 FEDATVYPAGAVPECDACG--KLLRPHIVWFGEYLDPADIQRIEDFSLRAATSGGRFVFL 187 Query: 175 AIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVE 230 A GTSG VYPAAG V + + G T +NL+P++ N F + + +V+P + Sbjct: 188 AAGTSGAVYPAAGIVDQVRKAGGKTWLVNLDPAENSNRFEHRIVDKSGEVLPTLAK 243 >UniRef50_A0LP75 Silent information regulator protein Sir2 n=3 Tax=Bacteria RepID=A0LP75_SYNFM Length = 244 Score = 185 bits (470), Expect = 9e-46, Method: Compositional matrix adjust. Identities = 101/227 (44%), Positives = 139/227 (61%), Gaps = 8/227 (3%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQP 65 V+VLTGAGISAESG+ TFR GLW +R D+ATPE F+ DP+LV FY RRQL P Sbjct: 23 VVVLTGAGISAESGVPTFRGEGGLWRTYRATDLATPEAFENDPKLVWEFYGW-RRQLLAP 81 Query: 66 EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVL 125 + PN H ALA+L+ + RF L+TQNID LH++AG+ N++ +HG L VRC++ G + Sbjct: 82 -LDPNPGHYALAELERRI-PRFTLITQNIDGLHQKAGSANILELHGNLWWVRCTRCGSLT 139 Query: 126 DWTGDVTPE-DKCHCCQFPAPLRPHVVWFGEM--PLGMDEIYMALSMADIFIAIGTSGHV 182 + PE +C C+ LRPHVVWFGEM P +D+ Y A+ + + +GTSG V Sbjct: 140 EDRTVPLPELPRCGSCR--GLLRPHVVWFGEMLEPKILDQAYEAIRDCGVMLVVGTSGTV 197 Query: 183 YPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFV 229 PAA A+ GA E+NL+P+ + G A +++P + Sbjct: 198 QPAASMGVIARKQGATVAEVNLDPTPYSGAYDISISGKAGEILPRLL 244 >UniRef50_C6Y0J4 Silent information regulator protein Sir2 n=1 Tax=Pedobacter heparinus DSM 2366 RepID=C6Y0J4_PEDHD Length = 227 Score = 172 bits (437), Expect = 7e-42, Method: Compositional matrix adjust. Identities = 106/237 (44%), Positives = 142/237 (59%), Gaps = 21/237 (8%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQ 64 RV++LT AGISAESG++TFR ADGLWE + + DVATPE + R+PELVQ FYN RR+ + Sbjct: 3 RVVILTDAGISAESGLKTFRDADGLWEGYNIADVATPEAWKRNPELVQRFYNERRKSVI- 61 Query: 65 PEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQV 124 E QPNAAH AL LQ ++TQNID+LHERAG NV+H+HG + + + V Sbjct: 62 -EAQPNAAHKALTLLQTKYN--VHIITQNIDDLHERAGAENVLHLHGIITRSQSDVDSAV 118 Query: 125 L----DWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSG 180 W ++ P C++ PLRPHVVWFGE + + ADIF IGTS Sbjct: 119 TYPIEGW--EIGP---SAVCEYGMPLRPHVVWFGENVPNLMPAAKICAKADIFAVIGTSL 173 Query: 181 HVYPAAG---FVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLK 234 VYPAAG +V + L + V+ N+ Q+ F ++ A+ VPE V++L+ Sbjct: 174 VVYPAAGLTDYVPDTALK--YAVDPNI--PQIKGNF-KRIEKAATIGVPEMVKELMN 225 >UniRef50_Q8A3H9 NAD-dependent deacetylase n=29 Tax=Bacteria RepID=NPD_BACTN Length = 234 Score = 171 bits (434), Expect = 2e-41, Method: Compositional matrix adjust. Identities = 92/189 (48%), Positives = 125/189 (66%), Gaps = 8/189 (4%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQP 65 ++VLTGAG+SAESGI TFR A GLW+++ VE VATPEG+ RDP LV FYNARR+QL Sbjct: 4 LVVLTGAGMSAESGISTFRDAGGLWDKYPVEQVATPEGYQRDPALVINFYNARRKQLL-- 61 Query: 66 EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVL 125 E++PN H LA+L+ ++TQN+DNLHERAG+++++H+HGEL KV S+ Sbjct: 62 EVKPNRGHELLAELEKNFN--VTVITQNVDNLHERAGSSHIVHLHGELTKVCSSRDPYNP 119 Query: 126 DWTGDVTPEDKCHCCQFPA----PLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGH 181 + ++ PE+ A LRP +VWFGE ++ + ADIF+ IGTS + Sbjct: 120 HYIKELKPEEYEVKMGDKAGDGTQLRPFIVWFGEAVPEIETAVRYVEKADIFVIIGTSLN 179 Query: 182 VYPAAGFVH 190 VYPAAG +H Sbjct: 180 VYPAAGLLH 188 >UniRef50_Q3V7G9 NAD-dependent deacetylase (Regulatory protein sirtuin family) n=11 Tax=Acinetobacter RepID=Q3V7G9_ACIAD Length = 233 Score = 170 bits (431), Expect = 3e-41, Method: Compositional matrix adjust. Identities = 92/199 (46%), Positives = 128/199 (64%), Gaps = 16/199 (8%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQ 64 +++V +GAG+SAESGI TFR DGLWE +R+E+VATPE + ++P LVQ FYN RR+ + Sbjct: 3 KLVVFSGAGMSAESGIHTFRDHDGLWENYRIEEVATPEAWQQNPSLVQHFYNERRKNILA 62 Query: 65 PEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCS----- 119 QPN AH +A+L+ + ++TQNID+LHERAG+T+V+H+HG + + S Sbjct: 63 A--QPNLAHQIIAQLESCY--QVQVITQNIDDLHERAGSTHVLHLHGNIRLAKSSGPNAQ 118 Query: 120 --QSGQVLD-WTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAI 176 Q+ +D W D+ +DKC+ PLRPHVVWFGE D+ L AD+FI I Sbjct: 119 FTQTFYPIDGWQLDLN-QDKCNEG---YPLRPHVVWFGEAVPAYDDAIAMLKDADVFIVI 174 Query: 177 GTSGHVYPAAGFVHEAKLH 195 G++ VYP AG +HE H Sbjct: 175 GSTLSVYPVAGLIHEIPNH 193 >UniRef50_A9GVG5 Transcriptional regulatory protein, Sir2 family n=1 Tax=Sorangium cellulosum 'So ce 56' RepID=A9GVG5_SORC5 Length = 269 Score = 169 bits (428), Expect = 8e-41, Method: Compositional matrix adjust. Identities = 101/253 (39%), Positives = 139/253 (54%), Gaps = 32/253 (12%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQ 64 ++ VLTGAG+SAESGI TFR A GLW + +A+PE + RDP LV FYN RR + Sbjct: 18 KIAVLTGAGVSAESGIPTFRGAGGLWRRYEATSLASPEAWRRDPGLVWEFYNHRRERALG 77 Query: 65 PEIQPNAAHLALAKLQDAL---GDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 PN H ALA+L+ G F L+TQNID LHE+AG+ + + +HG L +VRC Sbjct: 78 --CAPNPGHHALAQLEARWREAGRAFTLITQNIDGLHEKAGSRSPVRLHGSLWQVRCLSC 135 Query: 122 GQVLD---------WTGDVTPEDKCHCCQFPAP----------LRPHVVWFGEMPLGMDE 162 G V + + G +P+ + +F A LRPHVVWFGE + E Sbjct: 136 GSVTENRDVPITPAFAGSGSPDPEAPARRFTAAELPRCGCGGVLRPHVVWFGE---ALQE 192 Query: 163 IYMALSMA-----DIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKY 217 +A + A D+ + +GTS VYPAAGFV AK HGA E+N+EPS + + Sbjct: 193 SDLAAAAAGVEGCDLLLVVGTSAVVYPAAGFVPMAKRHGALIAEVNVEPSAISGLCDVVF 252 Query: 218 YGPASQVVPEFVE 230 G + ++P ++ Sbjct: 253 TGGSGAILPSLLD 265 >UniRef50_A7XXV9 Sirtuin 5 n=14 Tax=Eumetazoa RepID=A7XXV9_PIG Length = 310 Score = 169 bits (427), Expect = 1e-40, Method: Compositional matrix adjust. Identities = 94/249 (37%), Positives = 135/249 (54%), Gaps = 29/249 (11%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQP 65 ++V++GAG+SAESGI TFR A G W + + +D+ATP+ F R+P V FY+ RR +Q Sbjct: 53 IVVISGAGVSAESGIPTFRGAGGYWRKWQAQDLATPQAFARNPSRVWEFYHHRREVVQG- 111 Query: 66 EIQPNAAHLALAKLQDAL---GDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG 122 PNA HLA+A+ + L G R +++TQNID LH +AG N++ +HG L K RC+ G Sbjct: 112 -RAPNAGHLAIAQCEARLHGQGRRLVVITQNIDELHRKAGTRNLLEIHGSLFKTRCTSCG 170 Query: 123 QVLD---------WTGDVTPEDKCHCCQFPAP-------------LRPHVVWFGEM--PL 158 V + +G PE + + P LRPHVVWFGE P Sbjct: 171 AVAENYKSPICPALSGKGAPEPETQDARIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPA 230 Query: 159 GMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYY 218 ++E+ L++ D+ + +GTS VYPAA F + G E N+E + N F + Sbjct: 231 ILEEVDRELALCDLCLVVGTSSVVYPAALFAPQVSARGVPVAEFNVEATPATNRFRFHFQ 290 Query: 219 GPASQVVPE 227 GP +PE Sbjct: 291 GPCGTTLPE 299 >UniRef50_D2LLI1 Silent information regulator protein Sir2 n=3 Tax=Aciduliprofundum boonei T469 RepID=D2LLI1_9EURY Length = 245 Score = 168 bits (426), Expect = 1e-40, Method: Compositional matrix adjust. Identities = 98/240 (40%), Positives = 137/240 (57%), Gaps = 10/240 (4%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 + R++ LTGAGISAESGI TFR GLWE + VE VAT EGF+RDP LV FY+ RRR Sbjct: 11 LSAKRIVALTGAGISAESGIPTFRGTGGLWEGYPVEKVATIEGFERDPALVWKFYDERRR 70 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 + + +PN AH LA ++ L D F ++TQNID LH RAG+ NV+ +HG + +V+C++ Sbjct: 71 NIAKA--RPNRAHEVLALFEN-LYD-FWVITQNIDGLHSRAGSKNVVELHGNIWRVKCTE 126 Query: 121 SGQVLDWTGDVTPED---KCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIG 177 G + + +V + KC C LRP VVWFGE +D+ Y D+ + IG Sbjct: 127 CG-IRYYNYEVPLREIPPKCKRCG--GLLRPDVVWFGEPVYDVDKAYELTESCDVMLVIG 183 Query: 178 TSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKGLK 237 TS VYPAA A GA +E+N + + + A++ + E LL+ + Sbjct: 184 TSAQVYPAAYLPRLAWSKGAKIIEINPQETPISRYANFVIREKATKALDELYRGLLRAFQ 243 >UniRef50_Q1QTH0 Silent information regulator protein Sir2 n=3 Tax=Bacteria RepID=Q1QTH0_CHRSD Length = 242 Score = 166 bits (419), Expect = 7e-40, Method: Compositional matrix adjust. Identities = 104/236 (44%), Positives = 140/236 (59%), Gaps = 19/236 (8%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 + P ++VLTGAGISAESG++TFR DGLWE HRV+DVATPE F RDPE V FY+ARR Q Sbjct: 5 QGPHLVVLTGAGISAESGLKTFRDGDGLWENHRVQDVATPEAFARDPETVLRFYDARREQ 64 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 +Q PNAAH ALA+L+ A G + ++TQNID+LHERAG+ +V+H+HGE+L R S Sbjct: 65 TRQ--ATPNAAHRALAELEQA-GFQVSVITQNIDDLHERAGSRDVLHLHGEILMSRSSAD 121 Query: 122 -------GQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFI 174 G+ GD+ C + LRP VVWFGE + ++ AD+ + Sbjct: 122 PNLRYPVGRKGIRLGDL--------CDKGSQLRPDVVWFGEPVPRYAQACEIVAEADLVL 173 Query: 175 AIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVE 230 +GTS V PAA + +A + A + ++ + + ASQ VP VE Sbjct: 174 VVGTSLAVMPAAMLLDQAPIE-APCLLVDPQAESLVPRGVRAISQLASQGVPPLVE 228 >UniRef50_Q1QDL3 Silent information regulator protein Sir2 n=6 Tax=Bacteria RepID=Q1QDL3_PSYCK Length = 266 Score = 162 bits (411), Expect = 7e-39, Method: Compositional matrix adjust. Identities = 99/246 (40%), Positives = 140/246 (56%), Gaps = 21/246 (8%) Query: 3 KPRVLVLTGAGISAESGIRTFR-AADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 K + +LTGAGISAESGI TFR GLWE +R ED+ATP+ F RDP+LV ++Y RR+ Sbjct: 23 KQHICLLTGAGISAESGIPTFRDKQTGLWENYRAEDLATPDAFARDPKLVWSWYQWRRQL 82 Query: 62 LQQPEIQPNAAHLALAKLQ---DALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRC 118 + +PN AH ALA+ Q + + L+TQN+D+LHE+AG+ V H+HG L + RC Sbjct: 83 VASK--KPNPAHTALAQWQYHSQSTNQQLTLITQNVDDLHEQAGSA-VTHLHGNLWRNRC 139 Query: 119 SQS--------GQVLDWTGDVTPEDKCHCCQ-FPAPLRPHVVWFGE-MPL-GMDEIYMAL 167 SQ D ++ ++ CQ +RP +VWFGE +P+ A Sbjct: 140 SQCQTPYTIQLKSAYDSENSISFDEALMTCQHCDGYIRPDIVWFGESLPMRAWQTAEEAA 199 Query: 168 SMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAE-KYYGPASQVVP 226 + D+FI+IGTS VYPAAG AK +GA +E+N P N + A ++P Sbjct: 200 ANCDVFISIGTSSLVYPAAGLAQLAKHNGAKIIEIN--PYPTPNTLVDITLAAKAGAILP 257 Query: 227 EFVEKL 232 E V+++ Sbjct: 258 ELVKRM 263 >UniRef50_Q72IV5 NAD-dependent deacetylase n=8 Tax=Bacteria RepID=NPD_THET2 Length = 254 Score = 162 bits (411), Expect = 8e-39, Method: Compositional matrix adjust. Identities = 96/213 (45%), Positives = 124/213 (58%), Gaps = 9/213 (4%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 E RV VLTGAGIS SGI TFR A+GLW+ D ATPE + RDPE V A+Y R ++ Sbjct: 13 EAKRVAVLTGAGISKPSGIPTFRDAEGLWKNFNPLDYATPEAYARDPEKVWAWYAWRIQK 72 Query: 62 LQQPEIQPNAAHLALAKLQDAL---GDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRC 118 ++ E +PN AH AL +L+ + G FLLVTQN+D LH RAG+ N++ +HG LL+ RC Sbjct: 73 VR--EAKPNPAHYALVELERRILSRGGSFLLVTQNVDGLHARAGSQNLVELHGNLLRARC 130 Query: 119 SQSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGE-MPLG-MDEIYMALSMADIFIAI 176 G+ P C C A RP VVWFGE +P G + A + AD + + Sbjct: 131 EACGKRFPLPEAFAPPPFCPACGHRA--RPDVVWFGELLPEGAWERAERAFAEADFALVV 188 Query: 177 GTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQV 209 GTS V PAA A GA+ VE+N EP+ + Sbjct: 189 GTSAEVEPAASLGRIAFASGAYLVEVNPEPTPL 221 >UniRef50_B3EMB2 Silent information regulator protein Sir2 n=2 Tax=Chlorobiaceae RepID=B3EMB2_CHLPB Length = 230 Score = 162 bits (410), Expect = 9e-39, Method: Compositional matrix adjust. Identities = 87/225 (38%), Positives = 133/225 (59%), Gaps = 13/225 (5%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQP 65 ++ TGAG+SAESG+ T+R G+W + +++ A E FDR+PE V F+ RR+ + Sbjct: 13 IVFFTGAGMSAESGVPTYRGKGGIWGSYSIDEYACQEAFDRNPEKVLGFHEKRRKSVL-- 70 Query: 66 EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVL 125 + QP+ H +A L +A +VTQNID +H+RAG+ +VI +HG L ++RC G Sbjct: 71 DCQPHEGHSVVAVLPNA-----KVVTQNIDGMHQRAGSKDVIELHGSLWRLRCQSCGFRK 125 Query: 126 DWTGDVTPEDKCHCCQFPAPLRPHVVWFGEM--PLGMDEIYMALSMADIFIAIGTSGHVY 183 + + +C C LRP ++WFG+M + M + A+ D+F++IGTSG V+ Sbjct: 126 EDLAESYETTRCDCGD---RLRPDIIWFGDMLDAVVMSKASQAIRNCDLFVSIGTSGTVW 182 Query: 184 PAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEF 228 PAAGF AK GA+ +E+N EPS +E+ G A +V+PE Sbjct: 183 PAAGFPDLAKQSGAYCIEINPEPSGA-SEYDRVIVGNAGEVLPEL 226 >UniRef50_C6AKY4 Transcriptional regulator, Sir2 family n=5 Tax=Proteobacteria RepID=C6AKY4_AGGAN Length = 232 Score = 162 bits (410), Expect = 9e-39, Method: Compositional matrix adjust. Identities = 90/191 (47%), Positives = 121/191 (63%), Gaps = 8/191 (4%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 KP +VL+GAGISAESGI T+RA DGLW H++E+V TPE R+ + V FYN RRR Sbjct: 2 KPLCVVLSGAGISAESGIPTYRAEDGLWAGHKIEEVCTPEALQRNRKKVLDFYNERRRNC 61 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCS-QS 121 QPNAAH AL +L+ G ++TQN+D+LHERAG+ NV+H+HGEL K R Sbjct: 62 SA--AQPNAAHKALVELEQ--GYNVQIITQNVDDLHERAGSANVLHLHGELNKARSGFDP 117 Query: 122 GQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGH 181 ++ G+ + +DK P+RPH+V+FGE ++ +S AD+ + IGTS Sbjct: 118 DYIVPCFGEQSVDDKDPNGH---PMRPHIVFFGENVPMLEPAIDLVSQADVVLVIGTSLQ 174 Query: 182 VYPAAGFVHEA 192 VYPA G V+EA Sbjct: 175 VYPANGLVNEA 185 >UniRef50_C6A243 NAD-dependent deacetylase n=8 Tax=Euryarchaeota RepID=NPD_THESM Length = 255 Score = 160 bits (405), Expect = 3e-38, Method: Compositional matrix adjust. Identities = 95/255 (37%), Positives = 148/255 (58%), Gaps = 26/255 (10%) Query: 2 EKPRVLV-------LTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAF 54 E PR++ TGAG+SAESGI TFR GLWE +R+E+VATPE F +DP LV +F Sbjct: 4 EAPRIIAHSRFLIAFTGAGVSAESGIPTFRDRGGLWENYRIEEVATPEAFRKDPNLVWSF 63 Query: 55 YNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELL 114 Y R + ++ +PN AHLALA+L+ +G ++TQNIDNLH AGN +++ +HG + Sbjct: 64 YKMRMKIMKGA--KPNNAHLALAELEK-MGILKAVITQNIDNLHREAGNQHIVELHGNIY 120 Query: 115 KVRCS---------QSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYM 165 +V+C+ +SG++ D+ + ++ C + + LRP VVWFGE PL + + Sbjct: 121 RVKCTRCDYMENLLESGKLEDFLKE---KNLPKCPECASLLRPDVVWFGE-PLPQEALQK 176 Query: 166 ALSM---ADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPAS 222 A + AD+ + +GTS V+PAA + K +G +E+N + S + G A Sbjct: 177 AFKLAERADVCLVVGTSAQVFPAAYVPYIVKDNGGSVIEINTKESGITPIADVFIRGKAG 236 Query: 223 QVVPEFVEKLLKGLK 237 +V+ + K+ + L+ Sbjct: 237 EVMQSLLVKVKRCLE 251 >UniRef50_Q9ZJW8 NAD-dependent deacetylase n=58 Tax=Bacteria RepID=NPD_HELPJ Length = 234 Score = 160 bits (404), Expect = 4e-38, Method: Compositional matrix adjust. Identities = 87/188 (46%), Positives = 118/188 (62%), Gaps = 8/188 (4%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQP 65 +++L+GAGISAESGI+TFR A GLWE H + +VA+P G+ ++P+ V FYN RRRQL Sbjct: 4 LVILSGAGISAESGIKTFRDAGGLWEGHDIMEVASPYGWKKNPQKVLDFYNQRRRQL--F 61 Query: 66 EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS-GQV 124 E+ PN AH ALA+L+ + ++TQN+D+LHERAG++ ++H+HGELL VR + V Sbjct: 62 EVYPNKAHKALAELEKHY--QVNIITQNVDDLHERAGSSRILHLHGELLSVRSEKDPNLV 119 Query: 125 LDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGHVYP 184 W D+ D Q A LRP +VWFGE + E + + I IGTS VYP Sbjct: 120 YRWEKDLNLGD---LAQDKAQLRPDIVWFGEEVPLLKEAVSLVKQVHLLIIIGTSLQVYP 176 Query: 185 AAGFVHEA 192 AA A Sbjct: 177 AASLYTHA 184 >UniRef50_UPI0001744E27 NAD-dependent protein deacetylases, SIR2 family n=1 Tax=Verrucomicrobium spinosum DSM 4136 RepID=UPI0001744E27 Length = 232 Score = 159 bits (403), Expect = 6e-38, Method: Compositional matrix adjust. Identities = 91/227 (40%), Positives = 132/227 (58%), Gaps = 25/227 (11%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQ 64 +V+V++GAG+SA SG+ TFR +G W+++R EDVA+P ++R PE+V FYN RR + Sbjct: 10 KVVVISGAGLSAPSGLSTFRDNNGYWKQYRFEDVASPRAWERQPEVVLEFYNERR--TKA 67 Query: 65 PEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQV 124 ++PNA H A+A+L+D ++VTQN+D+LHERAG+T VIH+HGEL K R S S + Sbjct: 68 ASVEPNAGHRAIAELEDRF--EVVVVTQNVDDLHERAGSTRVIHLHGELNKAR-STSDES 124 Query: 125 LDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGHVYP 184 L + P C+ + LRPH+VWFGE +D ++ A + +GTS VYP Sbjct: 125 LVYELGARPIALGDLCEKGSQLRPHIVWFGEEVKAIDLAADEVASAGRVLVVGTSLKVYP 184 Query: 185 AAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYG--PASQVVPEFV 229 AAG +E+A K+Y A + VP+F Sbjct: 185 AAGLC------------------SCAHEYATKFYVDLDAKRQVPDFT 213 >UniRef50_D1B334 Silent information regulator protein Sir2 n=2 Tax=Campylobacterales RepID=D1B334_SULD5 Length = 230 Score = 159 bits (402), Expect = 9e-38, Method: Compositional matrix adjust. Identities = 89/227 (39%), Positives = 128/227 (56%), Gaps = 9/227 (3%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQ 64 +V++ +GAGISAESG+ TFR ADGLWE++R+E++ + E AFY+ARR QL Sbjct: 3 KVVIFSGAGISAESGLSTFRDADGLWEKYRIEEICQAGCLSWNRENTLAFYDARREQL-- 60 Query: 65 PEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQV 124 ++PN AH ALAKLQ+ + ++TQN+D+L ERAG +V+H+HG L ++RC Q G Sbjct: 61 TSVKPNTAHYALAKLQECYPNDIDIITQNVDDLFERAGCKDVLHLHGFLPRLRCEQCGAT 120 Query: 125 LDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGHVYP 184 G E C RP +V+FGE + +Y A+ + IG+SG+V Sbjct: 121 -QIIGYAKQERTFTCKNCGGSFRPDIVFFGEAAPMYEHLYEAMEDCQFLVIIGSSGNVIA 179 Query: 185 AAGFVHEAKLHGAHTVELNLEPSQVGNE--FAEKYYGPASQVVPEFV 229 F LH H++ NLE S NE + + Y A++ V E V Sbjct: 180 MDHFA----LHVKHSILNNLEKSDAINERVYTKVLYKKATEAVDEIV 222 >UniRef50_Q9NXA8 NAD-dependent deacetylase sirtuin-5 n=37 Tax=Metazoa RepID=SIRT5_HUMAN Length = 310 Score = 159 bits (401), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 90/249 (36%), Positives = 128/249 (51%), Gaps = 29/249 (11%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQP 65 +++++GAG+SAESG+ TFR A G W + + +D+ATP F +P V FY+ RR + Sbjct: 53 IVIISGAGVSAESGVPTFRGAGGYWRKWQAQDLATPLAFAHNPSRVWEFYHYRREVMGSK 112 Query: 66 EIQPNAAHLALAKLQDALGD---RFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG 122 E PNA H A+A+ + LG R +++TQNID LH +AG N++ +HG L K RC+ G Sbjct: 113 E--PNAGHRAIAECETRLGKQGRRVVVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCG 170 Query: 123 QVLD---------WTGDVTPEDKCHCCQFPAP-------------LRPHVVWFGEM--PL 158 V + +G PE P LRPHVVWFGE P Sbjct: 171 VVAENYKSPICPALSGKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPA 230 Query: 159 GMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYY 218 ++E+ L+ D+ + +GTS VYPAA F + G E N E + N F + Sbjct: 231 ILEEVDRELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTPATNRFRFHFQ 290 Query: 219 GPASQVVPE 227 GP +PE Sbjct: 291 GPCGTTLPE 299 >UniRef50_D2R126 Silent information regulator protein Sir2 n=1 Tax=Pirellula staleyi DSM 6068 RepID=D2R126_9PLAN Length = 256 Score = 158 bits (400), Expect = 1e-37, Method: Compositional matrix adjust. Identities = 93/232 (40%), Positives = 131/232 (56%), Gaps = 8/232 (3%) Query: 5 RVLVLTGAGISAESGIRTFR-AADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQ 63 R++VLTGAGISAESG+ TFR A GLW R E++ATPE F+++P+LV +Y RR+ Q Sbjct: 23 RLVVLTGAGISAESGLATFRDAMTGLWANFRAEELATPEAFEQNPKLVWDWYVWRRKLAQ 82 Query: 64 QPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQ 123 +PN AH AL +L+ L + +VTQN+D LH+RAG+ VI +HG L + +CS + Sbjct: 83 --AAKPNGAHFALVELER-LVPQLTIVTQNVDGLHQRAGSAGVIELHGSLSRFKCSTDNE 139 Query: 124 VLDWT--GDVTPEDKCHCCQFPAPLRPHVVWFGEM--PLGMDEIYMALSMADIFIAIGTS 179 +D GD C + A +RP +VWFGEM P + + D+F +IGTS Sbjct: 140 PVDAKDFGDSPDGMPPRCPRCHAFVRPDIVWFGEMLPPSALQTAFQVTKKCDLFFSIGTS 199 Query: 180 GHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEK 231 G V PAA A +GA + NL+ G A ++PE + + Sbjct: 200 GVVEPAASLPRRAIEYGASVMINNLDVDTASEPPLYSLQGKAGTILPELLRR 251 >UniRef50_A9AWG1 Silent information regulator protein Sir2 n=3 Tax=Bacteria RepID=A9AWG1_HERA2 Length = 244 Score = 157 bits (398), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 95/233 (40%), Positives = 134/233 (57%), Gaps = 13/233 (5%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQP 65 ++VLTGAGIS SG+R FR +G+W E +E AT ++ P+LV + R QLQ Sbjct: 13 IVVLTGAGISVASGVRPFRGPNGVWNEWDIERCATRTALEQSPQLVWQAFGPLRSQLQ-- 70 Query: 66 EIQPNAAHLALAKLQDALG--DRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCS--QS 121 QPNAAH ALA+ + +LG RF L+TQNID LH+ AG+ N++ HG L + RCS Q Sbjct: 71 TTQPNAAHRALARFEQSLGKHQRFTLITQNIDGLHQLAGSRNLVEFHGSLRQSRCSDEQC 130 Query: 122 GQ--VLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGE-MPLGMD-EIYMALSMADIFIAIG 177 Q +D C C PLRP +V F E +P+ + + +L D F+A+G Sbjct: 131 DQPSFVDQRAHTQTLPLCPTCG--KPLRPDIVLFEEAIPVWAETQAKRSLRECDFFLAVG 188 Query: 178 TSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNE-FAEKYYGPASQVVPEFV 229 TSG V+PAA F A++ GA T+ +NLEP + F E+ G A +++P + Sbjct: 189 TSGTVFPAAAFARTAQMLGARTMLVNLEPHAADDSAFEEQQIGRAEELLPTLL 241 >UniRef50_C7FPB6 NAD-dependent protein deacetylase n=4 Tax=environmental samples RepID=C7FPB6_9BACT Length = 247 Score = 156 bits (394), Expect = 7e-37, Method: Compositional matrix adjust. Identities = 86/233 (36%), Positives = 129/233 (55%), Gaps = 10/233 (4%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQ 64 RV V++GAGISAESGI TFR + GLWE R E++ATP+ F DPE V +Y R R Q Sbjct: 18 RVFVVSGAGISAESGIPTFRGSGGLWEGFRAEELATPQAFAADPERVWRWY--RWRAEQY 75 Query: 65 PEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQV 124 + PNA H +A + R L+ TQN+D LH RAG+ V+ +HG + +RC+ + Sbjct: 76 GDCAPNAGHDTIAAMASRY-RRLLVATQNVDGLHRRAGSPAVVELHGSIADMRCTACDTL 134 Query: 125 LDW---TGDVTPEDKCHCCQFPAPLRPHVVWFGEM--PLGMDEIYMALSMADIFIAIGTS 179 + T D P +C C +RPH++WFGE P ++ A AD+ + +GTS Sbjct: 135 APFPRGTEDSDPVPRCALCG--ERMRPHILWFGETYWPGILERAQQAAEEADVCLVVGTS 192 Query: 180 GHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 V+P A+ GA +++N E +++ GP+ +++PE E++ Sbjct: 193 AQVWPPVALALHAQASGAFLIDINPEATELSGRADAHLAGPSGRLLPELWERV 245 >UniRef50_Q2RZG2 Transcriptional regulator, Sir2 family n=2 Tax=Bacteria RepID=Q2RZG2_SALRD Length = 252 Score = 155 bits (393), Expect = 9e-37, Method: Compositional matrix adjust. Identities = 94/237 (39%), Positives = 131/237 (55%), Gaps = 8/237 (3%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 +E V VLTGAGISAESGI TFR GLWEE +++A E F +PELVQ +Y RR Sbjct: 13 VEAGHVAVLTGAGISAESGIPTFRDPGGLWEEFDPQELANVEAFLDNPELVQGWYRHRRE 72 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLK---VR 117 ++ + PNA H ALA L+ A +VTQN+D+LH RA + VI +HG + + Sbjct: 73 VVE--DAAPNAGHHALADLE-AHVPSMAVVTQNVDDLHNRAETSTVIELHGNITDNYCMD 129 Query: 118 CSQSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEM--PLGMDEIYMALSMADIFIA 175 C Q+ + + C +RP VVWFGEM P M++ AD+F++ Sbjct: 130 CEQAVGAAAVDAAIQDGEPARCPDCGGLVRPDVVWFGEMLPPDAMEQADATTEQADVFLS 189 Query: 176 IGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 +GTS VYPAA A+ GA+ E+N + + V ++ E GPA V+P V+ + Sbjct: 190 VGTSAVVYPAARLPVAAREQGAYVAEVNPDTTGVTDDVHETIRGPAGDVLPALVDAV 246 >UniRef50_B3QYR0 Silent information regulator protein Sir2 n=1 Tax=Chloroherpeton thalassium ATCC 35110 RepID=B3QYR0_CHLT3 Length = 244 Score = 153 bits (386), Expect = 6e-36, Method: Compositional matrix adjust. Identities = 98/247 (39%), Positives = 142/247 (57%), Gaps = 25/247 (10%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 K R+++ +GAG+SAES I TFR ++GLWE HR+EDVA+PEG+ R+P LV FY R ++ Sbjct: 2 KKRIVIFSGAGLSAESDIPTFRDSNGLWESHRIEDVASPEGWQRNPALVLDFYAKRYEKM 61 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG 122 Q +PN+AH A+AKL +L + +TQNIDNL E+AG V H+HG + +C Sbjct: 62 QT--CKPNSAHEAIAKL--SLRHEVICITQNIDNLLEQAGVETVWHLHGRIDVQKCEWHK 117 Query: 123 QV---------LDWTGDVTPE----DKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMA--L 167 + D++G + D C C LRP VVWFGE + M + Y+ + Sbjct: 118 SIPAYYDERFQCDFSGAIKRPIAFGDACPVCG--GQLRPDVVWFGEA-VDMRQSYLQELV 174 Query: 168 SMADIFIAIGTSGHVYPAAGFVH-EAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVP 226 DIFI +GTS VYPAAG + K+ + ++ S V ++F E G AS+ +P Sbjct: 175 RTTDIFIGVGTSAQVYPAAGLLSIFEKVRDKYFIDPKPAYS-VLSDF-EVLNGSASEKMP 232 Query: 227 EFVEKLL 233 V++L+ Sbjct: 233 LLVDQLI 239 >UniRef50_Q8R9N6 NAD-dependent deacetylase 1 n=2 Tax=Thermoanaerobacteraceae RepID=NPD1_THETN Length = 242 Score = 152 bits (385), Expect = 6e-36, Method: Compositional matrix adjust. Identities = 90/211 (42%), Positives = 128/211 (60%), Gaps = 23/211 (10%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQP 65 +VLTGAGIS ESGI TFR DGLW+++ E++ATP F R+P LV +Y+ RRR + + Sbjct: 16 TVVLTGAGISKESGIPTFRGEDGLWKKYNPEELATPWAFQRNPALVWEWYDYRRRIISK- 74 Query: 66 EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVL 125 +PN HL +A+ ++ + ++TQN+D LHE AG+TNVI +HG + KV+C++ Sbjct: 75 -AKPNKCHLLIAEFEERFKN-VRVITQNVDGLHEAAGSTNVIELHGNIWKVKCTKC---- 128 Query: 126 DWTG--------DVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSM---ADIFI 174 D+ G + PE C + + +RP VVWFGE PL D++ A+ + AD+FI Sbjct: 129 DFRGINREVPLSKIPPE----CPKCGSIVRPDVVWFGE-PLPSDKLTEAMELSQRADLFI 183 Query: 175 AIGTSGHVYPAAGFVHEAKLHGAHTVELNLE 205 IGTS V PAA A GA VE++ E Sbjct: 184 VIGTSLMVQPAASLPFLALERGAFVVEVSPE 214 >UniRef50_UPI000186E50A snf2 histone linker PHD ring helicase, putative n=2 Tax=Coelomata RepID=UPI000186E50A Length = 1709 Score = 152 bits (384), Expect = 9e-36, Method: Composition-based stats. Identities = 87/235 (37%), Positives = 124/235 (52%), Gaps = 29/235 (12%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQP 65 +L+LTGAG+SAESGI TFR G W +++ +++ATPE F +P LV FY+ RR Sbjct: 1476 LLILTGAGVSAESGIPTFRGPGGYWRKYQAQNLATPEAFRANPSLVWEFYHHRRETALTK 1535 Query: 66 EIQPNAAHLALAKLQDAL---GDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG 122 E PN AH A+A+ Q+ G + ++TQNID LH+RAG ++VI +HG L K RC + Sbjct: 1536 E--PNNAHKAIAECQNRFAKEGKKVWIITQNIDELHKRAGASDVIELHGSLFKTRCLKCK 1593 Query: 123 QV-----------LDWTGDVTP-----------EDKCHCCQFPAPLRPHVVWFGEM--PL 158 ++ LD G P +C LRPH+VWFGE P Sbjct: 1594 EIRENYDSPVCSALDGKGAPDPCAESADIPEKLLPRCKKENCGGLLRPHIVWFGENLDPK 1653 Query: 159 GMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEF 213 ++ A++ D+ + +GTS VYPAA F + G E N+E + +F Sbjct: 1654 VLELTEKAVNECDLCLVVGTSSVVYPAAMFAPQVAYRGVSVAEFNIESTPATGDF 1708 >UniRef50_C8S918 Silent information regulator protein Sir2 n=1 Tax=Ferroglobus placidus DSM 10642 RepID=C8S918_FERPL Length = 253 Score = 149 bits (377), Expect = 6e-35, Method: Compositional matrix adjust. Identities = 93/237 (39%), Positives = 135/237 (56%), Gaps = 19/237 (8%) Query: 7 LVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQPE 66 +V TGAG+SAESGI TFR DGLW ++VA+ GF R+P + F+ R + + + Sbjct: 21 VVFTGAGVSAESGIPTFRGNDGLWRRWDPDEVASIYGFRRNP---RKFWEFSRELIVKVK 77 Query: 67 IQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVLD 126 QPN AH A+A+L+ +G ++TQNID LH+RAG+ V+ +HG + V C G+ Sbjct: 78 AQPNPAHYAIAELEK-MGLVKAVITQNIDMLHQRAGSKRVLELHGSMQYVDCLDCGKTYK 136 Query: 127 W--------TGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALS---MADIFIA 175 W G++ DK C L+P VV+FGE PL + + A+ AD+FI Sbjct: 137 WEEIERFLEKGEI---DKIRCECGSIYLKPRVVFFGE-PLPSNVLSEAMEESRRADVFIV 192 Query: 176 IGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 +G+S VYPAA AK HGA + +NLEP+ + F G A +V+PE V+++ Sbjct: 193 VGSSLVVYPAAYLPVIAKEHGAKLIIVNLEPTMKDHIFDVVIRGKAGEVMPEIVKRV 249 >UniRef50_C1XSL0 NAD-dependent protein deacetylase, SIR2 family n=1 Tax=Meiothermus silvanus DSM 9946 RepID=C1XSL0_9DEIN Length = 265 Score = 148 bits (374), Expect = 1e-34, Method: Compositional matrix adjust. Identities = 95/229 (41%), Positives = 124/229 (54%), Gaps = 27/229 (11%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 E RV VLTGAGISA SGI TFR A GLW++ R+ED ATPE + RDP V +Y R Sbjct: 12 EAKRVAVLTGAGISAPSGIPTFRDAGGLWKDFRIEDYATPEAYRRDPLKVWEWYAWRYAN 71 Query: 62 LQQPEIQPNAAHLALAKLQDA-------LGDR----------FLLVTQNIDNLHERAGNT 104 Q QPN AH LA+L+ +GDR FLLVTQN+D LH RAG+T Sbjct: 72 AMQ--AQPNRAHRLLAELERQFTTPSPHVGDRLTPTAREGSGFLLVTQNVDGLHARAGST 129 Query: 105 NVIHMHGELLKVRCSQSGQ--VLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEM--PLGM 160 +++ +HG + + RC + G L G P C C RP VVWFGE+ P Sbjct: 130 HLVELHGSIGRARCEECGARFPLPDPGLFIPPPVCPKCGGRG--RPDVVWFGELLPPGAF 187 Query: 161 DEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQV 209 + A + A++ + +GTS + PAA A GA+ +E+N P+Q Sbjct: 188 ERAENAFAKAEVALVVGTSAEIEPAASLGRLASWAGAYLIEIN--PNQT 234 >UniRef50_Q8Y015 NAD-dependent deacetylase n=20 Tax=cellular organisms RepID=NPD_RALSO Length = 246 Score = 147 bits (372), Expect = 2e-34, Method: Compositional matrix adjust. Identities = 94/228 (41%), Positives = 123/228 (53%), Gaps = 8/228 (3%) Query: 5 RVLVLTGAGISAESGIRTFR-AADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQ 63 RV+VLTGAG+SAESG+ TFR A GLW ED+AT + P +V +Y RR ++ Sbjct: 23 RVMVLTGAGVSAESGVPTFRDALTGLWARFNPEDLATEAAYREHPRMVWDWYQERRARVS 82 Query: 64 QPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQ 123 Q +QPN AHLA+A L A LVTQN+D LH+RAG+ VI +HG L + Sbjct: 83 Q--VQPNPAHLAIAAL--ATRKTVALVTQNVDGLHQRAGSVGVIELHGNLFANKWLDGCG 138 Query: 124 VLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGE-MPLGMD-EIYMALSMADIFIAIGTSGH 181 D P C A LRP VVWFGE +P+ + A + D+ + +GTSG Sbjct: 139 KCD-VATAEPGRPPRCAACGAMLRPGVVWFGERLPVVANYRAEEAANTCDVCLVVGTSGM 197 Query: 182 VYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFV 229 VYPAAG AK HGA + +N EPS + + PA +P + Sbjct: 198 VYPAAGLPGLAKDHGARVIVVNPEPSVLDETADLVIHQPAGVCLPAML 245 >UniRef50_Q8F3Z6 NAD-dependent deacetylase n=4 Tax=Leptospira RepID=NPD_LEPIN Length = 246 Score = 147 bits (372), Expect = 3e-34, Method: Compositional matrix adjust. Identities = 88/237 (37%), Positives = 130/237 (54%), Gaps = 16/237 (6%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQ 64 ++ ++GAGISAESGI TFR ++GLW+ R ED+ATP+ F ++P+LV +Y RR ++ Sbjct: 14 KISAISGAGISAESGIPTFRGSEGLWKNFRAEDLATPQAFSKNPKLVWEWYLWRRNIIET 73 Query: 65 PEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQV 124 +PN H AL +L+ D F L+TQN+D LH +AG+ + +HG + RC GQ Sbjct: 74 K--RPNPGHFALVELERIHPD-FFLITQNVDGLHSQAGSKKLTEIHGNIFINRCISCGQE 130 Query: 125 LDWT--GDVTP-EDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSM-----ADIFIAI 176 T + TP +C C + LRP VVWFGE D+ + LS+ D+ + + Sbjct: 131 SKETISENTTPLPPQCQNCN--SFLRPGVVWFGE---SYDDFKLNLSIQRMKHTDLLLVL 185 Query: 177 GTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLL 233 GTSG V AK GA +E+N E S + G +V+PE + ++L Sbjct: 186 GTSGSVSMPVYLAQIAKDSGALLIEINPERSSFSSSVDLFLQGKTGEVLPELIREIL 242 >UniRef50_Q5HU51 NAD-dependent deacetylase n=15 Tax=Campylobacter RepID=NPD_CAMJR Length = 233 Score = 147 bits (370), Expect = 4e-34, Method: Compositional matrix adjust. Identities = 76/202 (37%), Positives = 122/202 (60%), Gaps = 5/202 (2%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQP 65 +++L+GAG+SA SG++TFR DGLWEE+ V +V + GF ++P+ V FY+ARR QLQ Sbjct: 4 IMILSGAGLSAPSGLKTFRDNDGLWEEYDVMEVCSATGFRKNPKKVLDFYDARRVQLQN- 62 Query: 66 EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVL 125 ++PN AH +A+L++ G ++TQN+D+L ERAG +V+H+HG L ++RC + + Sbjct: 63 -VKPNHAHEKIAQLKEKWGKNLFVITQNVDDLLERAGCKDVVHLHGFLPELRCLKCEGIF 121 Query: 126 DWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGHVYPA 185 + + + +C C+ LR ++V F E +Y L+ +FI+IGTSG V P Sbjct: 122 NIGYEKIIDKQCPKCK-SKDLRHNIVMFEEQAPAYATLYSLLNQTSLFISIGTSGAVLPV 180 Query: 186 AGFVH--EAKLHGAHTVELNLE 205 + E + + + NLE Sbjct: 181 GRYASMCEKSILNIYEKDANLE 202 >UniRef50_C3XIH7 NAD-dependent deacetylase n=4 Tax=Campylobacterales RepID=C3XIH7_9HELI Length = 236 Score = 146 bits (368), Expect = 6e-34, Method: Compositional matrix adjust. Identities = 90/238 (37%), Positives = 129/238 (54%), Gaps = 13/238 (5%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 M+ RV++ +GAG+SAESG+RTFR DGLWEE + +V + GF +D + V FY+ RR Sbjct: 1 MDSKRVMIFSGAGLSAESGLRTFRDNDGLWEEFDIMEVCSASGFAKDRKKVLDFYDKRRI 60 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 QL E+ PNAAH +A+L+ +++TQN+D+L ERAG NVIH+HG L +VRC Sbjct: 61 QL--GEVNPNAAHKMIARLKANYPQEVVVITQNVDDLLERAGCKNVIHLHGFLPEVRCEL 118 Query: 121 SGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMP-----LGMDEIYMALSMADIFIA 175 + + P+ C C LR ++V F E L + ++ S +F+ Sbjct: 119 CETITNIGYQAMPKLICESCG-EESLRHNIVMFSEYAPNYALLARELERLSESENSLFVC 177 Query: 176 IGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLL 233 IGTSG V A F AK +V NLE S F + A P+ +E+L+ Sbjct: 178 IGTSGEVLNVAQFSQCAK----KSVLNNLESSWFDECFNMCFIESAVSAAPK-IERLV 230 >UniRef50_B0SCR8 NAD-dependent protein deacetylase, SIR2 family n=2 Tax=Leptospira biflexa serovar Patoc RepID=B0SCR8_LEPBA Length = 251 Score = 146 bits (368), Expect = 6e-34, Method: Compositional matrix adjust. Identities = 84/234 (35%), Positives = 129/234 (55%), Gaps = 8/234 (3%) Query: 4 PRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQ 63 P ++ LTGAGIS+ESGI TFR GLW+ R ED+ATPE F ++P+LV +Y+ RR Q Sbjct: 16 PSIVFLTGAGISSESGIPTFRGEGGLWKNFRAEDLATPEAFQKNPKLVWEWYDWRREICQ 75 Query: 64 QPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQ 123 + +PN HL +AK Q L+TQN+D LH RAG+ +I +HG + +VRC+ Sbjct: 76 KA--KPNLGHLIIAKWQKK-SSSVHLITQNVDGLHPRAGSETLIELHGNIFRVRCTNCTS 132 Query: 124 V--LDWTGDVTPEDKCHCCQFPAPLRPHVVWFGE--MPLGMDEIYMALSMADIFIAIGTS 179 + L+ G P K C + + LRP +VWFGE + + + + + I IGTS Sbjct: 133 IFHLEKDGLDHPGLK-FCKECDSLLRPDIVWFGEEYNQNLLTKSWELCKQSQVVILIGTS 191 Query: 180 GHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLL 233 +V A +GA +E+N E + + + G + +V+P+ +++ Sbjct: 192 ANVSVPTNLAQTAIRNGAIGIEINPEETNLTPSMKHHFDGKSGEVLPQIWKEVF 245 >UniRef50_A9AWT4 Silent information regulator protein Sir2 n=1 Tax=Herpetosiphon aurantiacus ATCC 23779 RepID=A9AWT4_HERA2 Length = 243 Score = 145 bits (366), Expect = 1e-33, Method: Compositional matrix adjust. Identities = 92/235 (39%), Positives = 135/235 (57%), Gaps = 16/235 (6%) Query: 6 VLVLTGAGISAESGIRTFR--AADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQ 63 ++VLTG+GISA SGI T+R AAD W + + VAT GF+RDP V Y A +RQ + Sbjct: 18 LVVLTGSGISAPSGIPTYRSAAADARWTAYDPDKVATFAGFERDPVGVFQVYQAMKRQCE 77 Query: 64 QPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQ 123 QPNA H ALA+L+ LG +F L TQNID+LH+RAG++ V +HG L + CS+ G Sbjct: 78 --AAQPNAGHYALAQLEQ-LGTQFKLFTQNIDSLHQRAGSSQVYEVHGSLARTICSREGN 134 Query: 124 VLD-WTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMADIFIAIGTSG 180 +++ W + + C C APLRP +VWFGE+ + A +D+ + IGTS Sbjct: 135 LVETWNAE---QPICPACG--APLRPDIVWFGELLDAGILQAAKAAFDSSDVALVIGTSA 189 Query: 181 HVYPAAGFVHEAKLHGAHTVELNLE-PSQVGNEFAEKYYGPASQVVPEFVEKLLK 234 V P A H A +E+N + P + F+ G A +++P+ ++++ K Sbjct: 190 IVEPIASLPHRALRRKKTVIEINPDIPLRGIATFS--LAGSADELLPQLIKEVWK 242 >UniRef50_O30124 NAD-dependent deacetylase 2 n=18 Tax=cellular organisms RepID=NPD2_ARCFU Length = 253 Score = 145 bits (365), Expect = 2e-33, Method: Compositional matrix adjust. Identities = 91/234 (38%), Positives = 133/234 (56%), Gaps = 14/234 (5%) Query: 7 LVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQPE 66 +V TGAGISAESGI TFR DGLW ++ E+VA+ GF R+P +AF+ + Sbjct: 19 VVFTGAGISAESGIPTFRGEDGLWRKYDPEEVASISGFKRNP---RAFWEFSMEMKDKLF 75 Query: 67 IQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVLD 126 +PN AH A+A+L+ +G ++TQNID LH+RAG+ V+ +HG + K+ C + D Sbjct: 76 AEPNPAHYAIAELE-RMGIVKAVITQNIDMLHQRAGSRRVLELHGSMDKLDCLDCHETYD 134 Query: 127 WTGDVTPEDK-----CHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMA---DIFIAIGT 178 W+ V +K C C ++P VV FGE PL ++ A+ A D F+ +G+ Sbjct: 135 WSEFVEDFNKGEIPRCRKCG-SYYVKPRVVLFGE-PLPQRTLFEAIEEAKHCDAFMVVGS 192 Query: 179 SGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 S VYPAA + AK GA + +N EP+ F K G A +V+P+ VE++ Sbjct: 193 SLVVYPAAELPYIAKKAGAKMIIVNAEPTMADPIFDVKIIGKAGEVLPKIVEEV 246 >UniRef50_B1MER1 NAD-dependent deacetylase (Regulatory protein Sir2 homolog) n=4 Tax=Mycobacterium RepID=B1MER1_MYCA9 Length = 248 Score = 144 bits (362), Expect = 3e-33, Method: Compositional matrix adjust. Identities = 91/214 (42%), Positives = 122/214 (57%), Gaps = 15/214 (7%) Query: 6 VLVLTGAGISAESGIRTFR-AADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQ 64 V VLTGAG+SAESG+ TFR A GLW ++ +ATPE + DP LV A+Y RR QL Sbjct: 18 VTVLTGAGMSAESGLPTFRDAQTGLWSKYDPMTLATPESWQEDPGLVWAWYQNRRIQLLA 77 Query: 65 PEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQV 124 +QPN H ALA+ R +VTQN+D+LHERAG++NV H+HG LLK C Sbjct: 78 --VQPNDGHRALAQWGSHRDIR--IVTQNVDDLHERAGSSNVTHVHGSLLKSHCDTCRSD 133 Query: 125 LDWTGDVTPEDKCHC--CQFPAPLRPHVVWFGEMPLGMDEIYMALSMA-----DIFIAIG 177 + T ++ C +RP +VWFGEM + E+ ++A D+ + IG Sbjct: 134 FEATVSAPEAERVAPPECGCGGKVRPSIVWFGEM---LPEVEFGHAVAHSQNCDLMLLIG 190 Query: 178 TSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGN 211 TSG VYPAAG A GA VE+N + + + + Sbjct: 191 TSGIVYPAAGLPQLALSRGATVVEINPQETDLSD 224 >UniRef50_C2AS85 NAD-dependent protein deacetylase, SIR2 family n=1 Tax=Tsukamurella paurometabola DSM 20162 RepID=C2AS85_TSUPA Length = 273 Score = 142 bits (359), Expect = 8e-33, Method: Compositional matrix adjust. Identities = 97/247 (39%), Positives = 132/247 (53%), Gaps = 24/247 (9%) Query: 6 VLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQ 64 ++VLTGAG+SAESGI TFR A GLW + E++A+ + + RD LV +Y R +Q Sbjct: 30 IVVLTGAGMSAESGIATFREAQTGLWARYDPEEIASVDAWTRDSALVWGWYQWRGYIARQ 89 Query: 65 PEIQPNAAHLALAKLQDALGDR--FLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG 122 E PN H+ALA+L G R +VTQNID+LHERAG+ H+HG L RC G Sbjct: 90 AE--PNNGHIALAEL----GTRRSVSIVTQNIDDLHERAGSEVTAHLHGSLFAPRCEYCG 143 Query: 123 --------QVLDWTGDVTPEDKC---HCCQFPAPLRPHVVWFGEMPLGMD---EIYMALS 168 ++ G+ TPE + C Q + +RP +VWFGE PL M+ A+ Sbjct: 144 TPYLGSDAEIRATDGEPTPEMRVTPPTCMQCLSQVRPGIVWFGE-PLPMEAWGRAEAAVI 202 Query: 169 MADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEF 228 AD+ + IGTSG VYPAA A G VE+N EP+ + + A+ +P Sbjct: 203 AADLVLVIGTSGLVYPAARLPEMALEAGIPVVEINPEPTPLSARATVAWNTTAATGLPAL 262 Query: 229 VEKLLKG 235 V + G Sbjct: 263 VAAVTSG 269 >UniRef50_A9A3X3 Silent information regulator protein Sir2 n=4 Tax=marine archaeal group 1 RepID=A9A3X3_NITMS Length = 242 Score = 141 bits (355), Expect = 2e-32, Method: Compositional matrix adjust. Identities = 87/236 (36%), Positives = 134/236 (56%), Gaps = 13/236 (5%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQ 64 +++ +TGAGIS ESGI TFR DGLW + +AT + F DP+LV +YN RR + Sbjct: 16 KIVFVTGAGISQESGIPTFRGKDGLWRNYDAMKLATIDAFYDDPKLVWEWYNERRHNIFS 75 Query: 65 PEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQV 124 PN H A+A+L+ D L TQNID LH++AG+T V+ +HG ++K++C+ V Sbjct: 76 A--NPNQGHKAIAELE-KFADVVSL-TQNIDGLHQKAGSTKVLELHGSIVKIKCT----V 127 Query: 125 LDWTGDVTPE--DKCHCCQFPAPLRPHVVWFGE-MPLGM-DEIYMALSMADIFIAIGTSG 180 D++ ++ + + C+ + LRP VVWFGE +P + E + + D+ I +GTS Sbjct: 128 CDFSDEIMTDFTENPPLCKCGSILRPDVVWFGESLPQDVWQEAIIHANQCDLMIIVGTSL 187 Query: 181 HVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKGL 236 V PA AK + A +E+N E +++ +E ++ +PEFV L K L Sbjct: 188 VVSPANTLPIYAKQNNAMLIEINPENTEMSSEMDLVIRNTSANALPEFVS-LFKNL 242 >UniRef50_Q88BY5 NAD-dependent deacetylase n=11 Tax=Pseudomonas RepID=NPD_PSEPK Length = 262 Score = 140 bits (353), Expect = 3e-32, Method: Compositional matrix adjust. Identities = 95/239 (39%), Positives = 135/239 (56%), Gaps = 21/239 (8%) Query: 6 VLVLTGAGISAESGIRTFR-AADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQ 64 V+ TGAGISA+SGI TFR GLW +H + + T + F +P LV ++Y RR Q+ Q Sbjct: 17 VVFFTGAGISADSGIPTFRDKLTGLWAKHDPQRLETADAFRANPTLVWSWYLWRRHQVSQ 76 Query: 65 PEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRC------ 118 +PN+AHL++ +L DA D +VTQNID+LHERAG++ V+H+HG L+ V+C Sbjct: 77 --AKPNSAHLSIPQLADAGWD-VSVVTQNIDDLHERAGSSPVVHLHGSLMDVKCFGCHRP 133 Query: 119 ---SQSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGE-MPLGMDEIYMALSMA-DIF 173 S + G + +C C LRP VVWF E +P + L A D+ Sbjct: 134 AELSPDQLAVPLEGQLIEPPRCTRCN--GRLRPGVVWFRENLPDNAWRSAVRLVRACDLL 191 Query: 174 IAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYY--GPASQVVPEFVE 230 +++GTSG V PAAG A GA + +NLE VG + A++ GPA V+P ++ Sbjct: 192 VSVGTSGVVMPAAGIPDMALAVGATVIHVNLE--DVGMDGADEIMLEGPAGVVLPALLQ 248 >UniRef50_D1Y076 Transcriptional regulator, Sir2 family n=1 Tax=Prevotella bivia JCVIHMP010 RepID=D1Y076_9BACT Length = 248 Score = 138 bits (347), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 83/194 (42%), Positives = 112/194 (57%), Gaps = 9/194 (4%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 + +++V TGAGIS ESG+ TFR DGLW+ + +ATPEGF D E V FYN R+ L Sbjct: 16 RQKIVVFTGAGISKESGMETFRDLDGLWKRYDPAQIATPEGFAADTEFVLNFYNEMRKML 75 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG 122 +I+PN AH +A L++ ++TQNID+LHERAG+++VIH+HGEL KV S Sbjct: 76 I--DIEPNHAHKIVAALEE--WHDVTVITQNIDDLHERAGSSHVIHVHGELTKVTSSYDY 131 Query: 123 QVLDWTGDVTPEDKCHCCQFPA----PLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGT 178 + P DK A LRP++VWFGE + + AD + IGT Sbjct: 132 LNPRYIQPY-PLDKAIKVGDKALDGSQLRPYIVWFGESLPDLGACVQRMQQADYLLIIGT 190 Query: 179 SGHVYPAAGFVHEA 192 S V PAAG ++ A Sbjct: 191 SLTVMPAAGLINYA 204 >UniRef50_P66814 NAD-dependent deacetylase n=12 Tax=Mycobacterium tuberculosis complex RepID=NPD_MYCBO Length = 237 Score = 137 bits (346), Expect = 3e-31, Method: Compositional matrix adjust. Identities = 91/247 (36%), Positives = 129/247 (52%), Gaps = 25/247 (10%) Query: 5 RVLVLTGAGISAESGIRTFRA-ADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQ 63 RV VL+GAGISAESG+ TFR +GLW ++++ +G+ R+PE V +Y R + Sbjct: 2 RVAVLSGAGISAESGVPTFRDDKNGLWARFDPYELSSTQGWLRNPERVWGWYLWRHYLVA 61 Query: 64 QPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQ 123 ++PN H A+A QD ++TQN+D+LHERAG+ V H+HG L + RC++ G Sbjct: 62 N--VEPNDGHRAIAAWQDHA--EVSVITQNVDDLHERAGSGAVHHLHGSLFEFRCARCGV 117 Query: 124 VLDWTGDVTPE----------DKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSM---A 170 D PE C C +RP +VWFGE PL + A+ A Sbjct: 118 PYT---DALPEMPEPAIEVEPPVCDCGGL---IRPDIVWFGE-PLPEEPWRSAVEATGSA 170 Query: 171 DIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVE 230 D+ + +GTS VYPAAG A G +E+N EP+ + ASQ +P +E Sbjct: 171 DVMVVVGTSAIVYPAAGLPDLALARGTAVIEVNPEPTPLSGSATISIRESASQALPGLLE 230 Query: 231 KLLKGLK 237 +L LK Sbjct: 231 RLPALLK 237 >UniRef50_B1L5P3 NAD-dependent protein deacetylase, SIR2 family n=1 Tax=Candidatus Korarchaeum cryptofilum OPF8 RepID=B1L5P3_KORCO Length = 250 Score = 135 bits (341), Expect = 9e-31, Method: Compositional matrix adjust. Identities = 87/232 (37%), Positives = 130/232 (56%), Gaps = 8/232 (3%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQ 64 +V+ TGAGISAE+GI TFR GLWE++ E++ATP+ F RDP+LV +Y R + + Sbjct: 19 KVVAFTGAGISAEAGIPTFRGKGGLWEKYDPEELATPQAFFRDPKLVWDWYLWRMSIIAR 78 Query: 65 PEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ-SGQ 123 +P AH LA +D G ++TQN+D LH+RAG+ N++ +HG + ++RC+ + Sbjct: 79 A--RPTPAHEILALWEDK-GILKGVITQNVDGLHQRAGSKNLVELHGSIWRIRCTSCDNK 135 Query: 124 VLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSM---ADIFIAIGTSG 180 V G++ C + + +RP VVWF E PL DE A M A + + IGTSG Sbjct: 136 VYLGFGNLPERVPPECDRCGSIMRPDVVWFYE-PLPRDEWMRAEDMIRSASLLLIIGTSG 194 Query: 181 HVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 V PAA A + A VE+N E + + + + AS++ + E L Sbjct: 195 LVMPAATLPMMALRNNATLVEINPEETNLSSLAKFRVREGASRIFVDLNEML 246 >UniRef50_B6GXN1 Pc12g08000 protein n=1 Tax=Penicillium chrysogenum Wisconsin 54-1255 RepID=B6GXN1_PENCW Length = 267 Score = 135 bits (339), Expect = 1e-30, Method: Compositional matrix adjust. Identities = 95/247 (38%), Positives = 131/247 (53%), Gaps = 26/247 (10%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQ 64 R++ L GAGISA SG+ TFR A GLW H +ATPE FD P LV FY+ RR Q Sbjct: 26 RIVALLGAGISASSGLPTFRGAGGLWRSHDATSLATPEAFDETPGLVWQFYSYRRHMALQ 85 Query: 65 PEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTN---VIHMHGELL-----KV 116 + PN AH ALA+L D FL ++QN+D L+ A + GE L +V Sbjct: 86 AD--PNRAHYALAELARRNED-FLTLSQNVDGLNPSATDKTGEQASKAIGEALDDTSTEV 142 Query: 117 RCSQSGQVLDWTGDVTPED--KCHCCQFPAPLRPHVVWFGEMPLGMDEI-----YMALSM 169 S + + V ED +C C+ LRP VVWFGE PL I ++A Sbjct: 143 DISDASNPI---ATVAREDLPQCPKCE-DGLLRPGVVWFGE-PLPEKTIRAVDKWIAAGP 197 Query: 170 ADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNE--FAEKYY-GPASQVVP 226 D+ + IGTS V+PAAG+VHEA+ GA N++P+ E + + ++ G A +VP Sbjct: 198 VDLCLVIGTSAKVFPAAGYVHEARSQGARVAVCNMDPNDTPGELHYGDWFFQGDAGVIVP 257 Query: 227 EFVEKLL 233 E ++ ++ Sbjct: 258 EILKSVI 264 >UniRef50_Q46ZJ9 Silent information regulator protein Sir2 n=4 Tax=Bacteria RepID=Q46ZJ9_RALEJ Length = 260 Score = 134 bits (337), Expect = 3e-30, Method: Compositional matrix adjust. Identities = 89/205 (43%), Positives = 112/205 (54%), Gaps = 8/205 (3%) Query: 6 VLVLTGAGISAESGIRTFR-AADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQ 64 V VLTGAGISAESG+ TFR A GLW E++A+ E + R P LV +Y RR + Sbjct: 29 VFVLTGAGISAESGVPTFRDALTGLWARFDPEELASEEAYRRQPALVWEWYQHRRDLVAA 88 Query: 65 PEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQV 124 +PN AH AL L A LVTQN+D LH+RAG+ +VI +HG L + Sbjct: 89 --ARPNPAHYALVAL--AAQKTVTLVTQNVDGLHQRAGSDHVIELHGNLFANKWLNGCGR 144 Query: 125 LDWTGDVTPEDKCHCCQFPAPLRPHVVWFGE-MP-LGMDEIYMALSMADIFIAIGTSGHV 182 D P D C A +RP VVWFGE +P + A AD+ + +GTSG V Sbjct: 145 CD-EATAIPGDPPRCSLCGALMRPGVVWFGEDLPRVARFRAEHAAETADLCLVVGTSGLV 203 Query: 183 YPAAGFVHEAKLHGAHTVELNLEPS 207 YPAAG A+ HGA V +N +PS Sbjct: 204 YPAAGLPGLARDHGARVVVVNPQPS 228 >UniRef50_C1AAZ7 NAD-dependent deacetylase n=4 Tax=Bacteria RepID=C1AAZ7_GEMAT Length = 327 Score = 134 bits (336), Expect = 3e-30, Method: Compositional matrix adjust. Identities = 92/243 (37%), Positives = 125/243 (51%), Gaps = 21/243 (8%) Query: 6 VLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQ 64 V VLTGAGISAESGI TFR A GLW + +++ATP+ F P V +Y RR ++ Sbjct: 89 VCVLTGAGISAESGIPTFREAQTGLWAKFSPQELATPQAFASHPSRVWQWYAMRRAMVR- 147 Query: 65 PEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQV 124 QPN H AL L + +VTQN+D+LHER+G I +HG L+ +RCSQ Sbjct: 148 -AAQPNPGHAALLSLALRVAH-CTIVTQNVDDLHERSGVREPIRLHGSLMHIRCSQG--- 202 Query: 125 LDWTGDV-TPEDKC----HCCQFPAPLRPHVVWFGE-MPLG-MDEIYMALSMADIFIAIG 177 G V PE+ C Q +RP VVWFGE +P+G A D+F+++G Sbjct: 203 --CAGSVPAPEEATAEVPKCPQCGGLMRPDVVWFGEGLPMGPFGAAREAAVACDVFLSVG 260 Query: 178 TSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYY---GPASQVVPEFVEKLLK 234 TS V PAA + HGA + +N P+ G GPA ++P + + Sbjct: 261 TSNIVEPAASLPWISATHGATVIVVN--PTMEGQRKGPSILPIEGPAGVMLPRLIAEAFA 318 Query: 235 GLK 237 G + Sbjct: 319 GRR 321 >UniRef50_B2VWU1 NAD-dependent deacetylase sirtuin-5 n=3 Tax=Leotiomyceta RepID=B2VWU1_PYRTR Length = 320 Score = 133 bits (335), Expect = 4e-30, Method: Compositional matrix adjust. Identities = 91/281 (32%), Positives = 139/281 (49%), Gaps = 55/281 (19%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQ 64 R+L L GAG+SA SG+ TFR A G+W H +ATP+ F+RDP LV FY+ RR + Sbjct: 28 RILALLGAGLSASSGLPTFRGAGGMWRTHDATSLATPQAFERDPGLVWQFYSYRRHMALK 87 Query: 65 PEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGN--TNVIHMHGELLKVRCS--- 119 +PN AH ALA+L + F+ ++QN+D L RA + + +HG L V+CS Sbjct: 88 --AKPNPAHYALAELARKR-EEFITLSQNVDGLSPRAQHPIDKLKLLHGSLFDVKCSDFF 144 Query: 120 -QSGQVLDWTGDVTPE---------------------------------DKCHCCQFPAP 145 + + ++T + P D H PA Sbjct: 145 CKYVERNNYTDPIVPALAIPSDDSDPTTTSALAARELDISDINVAIPELDYSHLPHCPAC 204 Query: 146 ----LRPHVVWFGE-MPLGMDEIYMALSM----ADIFIAIGTSGHVYPAAGFVHEAKLHG 196 LRP VVWFGE +P + + D+ + IGTS VYPAAG+V EA++ G Sbjct: 205 KTGLLRPGVVWFGEALPKDVMKDVDDFIDDDRNVDLIMVIGTSAKVYPAAGYVDEARMKG 264 Query: 197 AHTVELNLEPSQV--GNEFAEKYY--GPASQVVPEFVEKLL 233 A +N++P + G + + ++ G A+++VPE ++ ++ Sbjct: 265 ARVAVINMDPEDIPAGGLYDKDWFFQGDAARIVPELLKSVI 305 >UniRef50_Q7VIN2 NAD-dependent deacetylase n=1 Tax=Helicobacter hepaticus RepID=NPD_HELHP Length = 255 Score = 133 bits (334), Expect = 6e-30, Method: Compositional matrix adjust. Identities = 86/251 (34%), Positives = 131/251 (52%), Gaps = 25/251 (9%) Query: 4 PRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQ 63 P+++V +GAG+SAESG+ TFR GLW ++ +V E + + ELV FYN RR +L Sbjct: 2 PKLVVFSGAGLSAESGLETFRDNGGLWAQYDPMEVCNYENWLDNFELVHRFYNLRREELG 61 Query: 64 QPEIQPNAAHLALAKLQDALGD---------------RFLLVTQNIDNLHERAGNTNVIH 108 + +QPNA H LA L L + +TQN+D+L ERAG +NVIH Sbjct: 62 K--VQPNAMHKFLASLPMILNKPRIALSAKKKHKDPIEVIHITQNVDDLLERAGVSNVIH 119 Query: 109 MHGELLKVRCSQSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMP---LGMDEIYM 165 +HGEL K+ C Q + D C C + L+P +V+F E + M +I+ Sbjct: 120 LHGELCKIICPQCEHIFDIGYTHFEPHNCPNCDY-GKLKPFIVFFYERAPKYVIMHDIFS 178 Query: 166 ALSMADIFIAIGTSGHVYPAAGFV--HEAKLHGAHTVELNLE--PSQVGNEFAEKYYGPA 221 LS D + IGTSG+V + + E++ + + NL+ PS + F + +Y P Sbjct: 179 QLSSKDCVLVIGTSGNVVDISTILAFAESRARIGYKILNNLQYCPSIAESVFDKIFYKPT 238 Query: 222 SQVVPEFVEKL 232 +Q + E ++L Sbjct: 239 TQAIAEIEQEL 249 >UniRef50_Q9I4L0 NAD-dependent deacetylase 1 n=28 Tax=Bacteria RepID=NPD1_PSEAE Length = 250 Score = 132 bits (333), Expect = 8e-30, Method: Compositional matrix adjust. Identities = 98/243 (40%), Positives = 135/243 (55%), Gaps = 17/243 (6%) Query: 5 RVLVLTGAGISAESGIRTFR-AADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQ 63 R+++ TGAG+SAESGI TFR A GLW + +ATP F DP LV +Y RR L+ Sbjct: 13 RLVIFTGAGVSAESGIPTFRDALGGLWARYDPAALATPAAFADDPALVWGWYEWRR--LK 70 Query: 64 QPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQ 123 +QPN AH A+A L + + LVTQN+D+LHERAG+ +V+H+HG L RC+ Sbjct: 71 VLGVQPNPAHRAIAALSGRIAN-TRLVTQNVDDLHERAGSRDVLHLHGSLHAPRCATCAA 129 Query: 124 VL-DWTGD-VTPED-------KCHCCQFPAPLRPHVVWFGE-MP-LGMDEIYMALSMADI 172 D D V PE+ +C C +RP VVWFGE +P + E + A D+ Sbjct: 130 AYRDALPDSVEPEEGRRIEPPRCPACG--GQVRPGVVWFGEALPEAALREAFAAACECDL 187 Query: 173 FIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 +++GTSG V PAA A HGA V +N +P + + GPA +V+PE + + Sbjct: 188 LLSVGTSGVVQPAARIPGLALEHGASVVHVNPQPVRTRHPREHCLVGPAGEVLPELLRRA 247 Query: 233 LKG 235 G Sbjct: 248 FPG 250 >UniRef50_B6KET2 NAD-dependent deacetylase, putative n=3 Tax=Toxoplasma gondii RepID=B6KET2_TOXGO Length = 360 Score = 131 bits (330), Expect = 2e-29, Method: Compositional matrix adjust. Identities = 92/237 (38%), Positives = 130/237 (54%), Gaps = 31/237 (13%) Query: 6 VLVLTGAGISAESGIRTFR-AADGLWEEHRVEDVATPEGFDRDP----ELVQAFYNARRR 60 V+ LTGAG+SAESGI TFR +DGLW+++ AT GF R P EL+ F Sbjct: 127 VVALTGAGVSAESGIPTFRDPSDGLWKKYDPTVYATIWGFWRYPHKIWELLLDF------ 180 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 L+ + PNAAH+AL LQ LG +VTQN+DNLH+ +G+TNVI HG LL C Q Sbjct: 181 -LRTNDPMPNAAHVALTDLQ-RLGYLKFIVTQNVDNLHQDSGSTNVIEYHGSLLSATCRQ 238 Query: 121 SGQVL----------DWTGDVTPEDKCHCCQFPAPLRPHVVWFGE-MPL-GMDEIYMALS 168 G+ + ++ D+ P KC C +P V+ FGE +P + + + Sbjct: 239 CGKKMRLSKSMLQDENFAKDLPP--KCAC---GGIFKPDVILFGEGIPANAVRDANREVD 293 Query: 169 MADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYY-GPASQV 224 D+ + +GTS V PA+ + A GA VE+NLE + + N ++K+ G ASQ+ Sbjct: 294 KCDLLLVVGTSASVSPASDLPYRAMRGGAKVVEVNLETTGLTNRISDKFVQGRASQL 350 >UniRef50_Q6BVM7 DEHA2C01386p n=4 Tax=Saccharomycetaceae RepID=Q6BVM7_DEBHA Length = 301 Score = 130 bits (328), Expect = 3e-29, Method: Compositional matrix adjust. Identities = 93/291 (31%), Positives = 143/291 (49%), Gaps = 57/291 (19%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 M+ R++ L GAG+S SG+ TFR + GLW+ + D+ATP+ F DP LV FY+ RR Sbjct: 13 MKSKRIVALVGAGLSVSSGLPTFRGSQGLWKNFNMIDLATPDAFYIDPGLVWQFYSWRR- 71 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELLKVRC 118 + + +PN HLALAKL F+ +TQN+D L RAG + +HG L +RC Sbjct: 72 -INASKAKPNKGHLALAKLSKLSNIEFMTITQNVDGLSIRAGHPKEKLHEIHGSLFDLRC 130 Query: 119 S----------------------------QSG---QVLDWT--GDVTPE----------- 134 + +SG +++D T ++P+ Sbjct: 131 TSFMCNYVDHDNFKNPLTKALADTEFEYDKSGRKRKIIDETEVNKLSPQFAPVKQIPEEE 190 Query: 135 -DKCHCCQFPAPLRPHVVWFGE-MPL-GMDEI--YMALSMADIFIAIGTSGHVYPAAGFV 189 +C C+ + LRP VVWFGE +PL +D+I ++ D+ + IGTSG VYPA +V Sbjct: 191 LPQCPVCEDGSLLRPGVVWFGESLPLQTIDKIDNFIESDKIDLILVIGTSGTVYPANSYV 250 Query: 190 HEAKLHGAHTVELN--LEPSQVGNEFAEK--YYGPASQVVPEFVEKLLKGL 236 KL G N +E + E + + G A++++P ++ L+ L Sbjct: 251 DRIKLKGGKVAIFNTDIESEILNGEEKDTWGFQGDAAELLPIALKPLIGDL 301 >UniRef50_A9SDL4 SIR2 family protein n=2 Tax=Physcomitrella patens subsp. patens RepID=A9SDL4_PHYPA Length = 323 Score = 129 bits (324), Expect = 8e-29, Method: Compositional matrix adjust. Identities = 88/216 (40%), Positives = 112/216 (51%), Gaps = 28/216 (12%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQ 64 +V+VLTGAGISAESGI TFR GLW + ++ATP F +P LV FY+ RR + Sbjct: 49 KVVVLTGAGISAESGIPTFRGEGGLWRDFDATELATPGAFAANPSLVWEFYHYRRTIVAG 108 Query: 65 PEIQPNAAHLALAKLQ---DALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 PNA H A+A LQ LG F+L+TQNID LH +AG+T+V+ +HG L + RC Sbjct: 109 A--SPNAGHYAVAALQRRCRRLGKDFILLTQNIDGLHAKAGSTDVVELHGSLWETRCCHC 166 Query: 122 GQV-----------LDWTG--DVTPEDKCHCCQFP------APLRPHVVWFGEMPLGMDE 162 V LD G D E Q P LRP V+WFGE L D Sbjct: 167 KAVEANRNMPICPALDGKGAPDTVHEANIPSMQLPRCNKCNGLLRPRVIWFGEC-LERDV 225 Query: 163 IYM---ALSMADIFIAIGTSGHVYPAAGFVHEAKLH 195 + AL D+ + +GTS VY + E +LH Sbjct: 226 LRRTDDALQGCDLLLVVGTSAVVYLFWRNMMEVELH 261 >UniRef50_C4QC33 Chromatin regulatory protein sir2, putative n=1 Tax=Schistosoma mansoni RepID=C4QC33_SCHMA Length = 305 Score = 129 bits (324), Expect = 9e-29, Method: Compositional matrix adjust. Identities = 86/260 (33%), Positives = 121/260 (46%), Gaps = 36/260 (13%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQP 65 VL TGAGISAES + TFR + W +D+ATP+ F +P LV FY+ R ++ Sbjct: 46 VLAFTGAGISAESHVPTFRRSGESWRNFHTQDLATPDAFHSNPGLVWEFYHYCREVVRSR 105 Query: 66 EIQPNAAHLALA---KLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG 122 PNA HLALA K G F ++TQN+D LH +AG NV+ +HG L K RC + Sbjct: 106 --CPNAGHLALAHAEKQYTECGRSFFIITQNVDGLHAKAGCVNVLELHGNLYKTRCLECN 163 Query: 123 QV---------LDWTGDVTPEDKCHCCQFPAP-------------------LRPHVVWFG 154 + G +P + C+ P P LRPHVVWFG Sbjct: 164 DIRVNFDKPICAALLGRGSPIIENIPCK-PIPLSQLPRCQNRINNNICGGLLRPHVVWFG 222 Query: 155 EM--PLGMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNE 212 E P + + + AD+ + +G S VYP A F G E+N+E + + Sbjct: 223 ENLEPHILSKAGEIVQKADVCLVVGASSAVYPVASFTRSLANRGIPVAEINVEVTPATHL 282 Query: 213 FAEKYYGPASQVVPEFVEKL 232 + G + V+P+ + L Sbjct: 283 LQYHFQGKSGDVLPKLFDSL 302 >UniRef50_C8QW70 Silent information regulator protein Sir2 n=1 Tax=Desulfurivibrio alkaliphilus AHT2 RepID=C8QW70_9DELT Length = 265 Score = 128 bits (322), Expect = 1e-28, Method: Compositional matrix adjust. Identities = 87/235 (37%), Positives = 124/235 (52%), Gaps = 13/235 (5%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQP 65 L LTGAGIS ESGI FR+A GLW + AT E F +DP V R L + Sbjct: 18 TLALTGAGISVESGIPDFRSAGGLWARFNPAEYATIEAFRQDPHKVWRMLAEMDRLLVRS 77 Query: 66 EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVL 125 +PN AHL LA+L+ LG ++TQN+DNLH+ G+ VI HG + C V Sbjct: 78 --RPNPAHLGLAELER-LGYLQFVITQNVDNLHQAGGSQRVIEFHGNAATLACLACHAVY 134 Query: 126 ---DWTGDVTPEDKCHCCQFPAPLRPHVVWFGEM--PLGMDEIYMALSMADIFIAIGTSG 180 + + P KC C Q L+P V++FGE P + + + +S+A + + IGTS Sbjct: 135 SRAEVSNQAVP-PKCVCGQV---LKPEVIFFGEEIPPPVLAQAHDLVSLARVLLVIGTSA 190 Query: 181 HVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYY-GPASQVVPEFVEKLLK 234 V PA+ AK HGA VE+N E +++ +E + G A +++P V +L + Sbjct: 191 EVAPASMLPRLAKEHGATIVEINPEKTRLTDELTDILLQGRAGEIIPALVAELKR 245 >UniRef50_A5USR3 Silent information regulator protein Sir2 n=3 Tax=Chloroflexi (class) RepID=A5USR3_ROSS1 Length = 259 Score = 128 bits (322), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 83/209 (39%), Positives = 119/209 (56%), Gaps = 13/209 (6%) Query: 5 RVLVLTGAGISAESGIRTFRAA-DGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQ 63 RV+ LTG G++AESGI +FR A G W ++ V ++ATP+ F R+P LV +Y A RR L Sbjct: 18 RVVALTGGGVAAESGIPSFREAHTGHWAQYDVSELATPQAFVRNPRLVWEWY-AYRRMLA 76 Query: 64 QPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQ 123 + QP H AL L+ F L+TQ+ID LH RAG+ ++I ++G L + RC +SG Sbjct: 77 E-RAQPGVTHYALVDLEQHY-PAFTLITQSIDGLHWRAGSRDLIELNGSLRRCRCFESGH 134 Query: 124 V---LDWTGDVTPEDKCHCCQFPAPLRPHVVWFGE-MP-LGMDEIYMALSMADIFIAIGT 178 + D G++ P C Q + LRP VV FGE +P + A+ D+F+ +GT Sbjct: 135 IAFAWDDDGEIPPR----CVQCGSLLRPDVVMFGEGLPHHELRRARQAVEQCDVFLCVGT 190 Query: 179 SGHVYPAAGFVHEAKLHGAHTVELNLEPS 207 G + P A F A+ HGA + + E S Sbjct: 191 VGAIEPVASFPFVARRHGAFVMTIAPEDS 219 >UniRef50_A2QWZ2 Function: human SIRT5 belongs to the Sir2-like proteins n=1 Tax=Aspergillus niger CBS 513.88 RepID=A2QWZ2_ASPNC Length = 258 Score = 128 bits (321), Expect = 2e-28, Method: Compositional matrix adjust. Identities = 86/245 (35%), Positives = 130/245 (53%), Gaps = 28/245 (11%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQ 64 RV+ L GAGISA SG+ TFR A GLW + D+ATPE FD +P+LV FY+ RR + Sbjct: 23 RVIALLGAGISASSGLPTFRGAGGLWRSYDATDLATPEAFDANPDLVWQFYSYRRHMALK 82 Query: 65 PEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHG------ELLKVRC 118 QPN AH ALA+L D F+ ++QN+D+ + ++ G ++ R Sbjct: 83 --AQPNRAHYALAELARKNKD-FITLSQNVDDRTGEEASRSIASALGNNEDEADVSDERV 139 Query: 119 SQSGQVLDWTGDVTPEDKCHC--CQFPAPLRPHVVWFGE-MP---LGMDEIYMALSMADI 172 S V E+ HC C+ LRP VVWFGE +P + + ++ D+ Sbjct: 140 PLSA--------VPYEELPHCPECK-DGLLRPGVVWFGESLPSHTIDYVDEWLNKGKVDL 190 Query: 173 FIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEK----YYGPASQVVPEF 228 + +GTS VYPAAG+V +A+ GA +N++ + VG+ + + G A +VPE Sbjct: 191 ILVVGTSSRVYPAAGYVDKARSKGARVAVVNMDRNDVGSSGLKPGDWFFEGDAGTIVPEI 250 Query: 229 VEKLL 233 ++ ++ Sbjct: 251 LKGVI 255 >UniRef50_D2VWA2 Silent information regulator family protein n=1 Tax=Naegleria gruberi RepID=D2VWA2_NAEGR Length = 297 Score = 127 bits (320), Expect = 3e-28, Method: Compositional matrix adjust. Identities = 89/255 (34%), Positives = 132/255 (51%), Gaps = 28/255 (10%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWE----EHRVEDVATPEGFDRDPELVQAFYNARRR 60 RV+V +GAG+SAESGI TFR GLW + + TP G++ P++ Y +R Sbjct: 28 RVVVFSGAGMSAESGIDTFRGGGGLWTGLMGKLFLAYGGTPFGWNITPQICWGQY-IKRF 86 Query: 61 QLQQPEIQPNAAHLALAKL-QDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCS 119 + PN H ALAKL Q+ GD ++TQN+D LH+RAG+T+V +HG +++ C Sbjct: 87 YGPIAKADPNNGHFALAKLEQEVFGDYMEVITQNVDGLHQRAGSTHVYEVHGTVMRHCCI 146 Query: 120 QSGQVLD---WTGDVTPE------DKCHCCQFP---APLRPHVVWFGEMPLGMDEIYMA- 166 + D + G+ E DK C+ P + LRP V F E L MD+ + Sbjct: 147 AERHIFDFDEYWGEENDEKKMDLPDKSPKCKHPGCNSTLRPDCVLFTEA-LPMDQWEPSF 205 Query: 167 -----LSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYY--G 219 + D+ I +GTS VYPAA A GAH +E NLE + N+ + G Sbjct: 206 HAVDRMRKGDVMICVGTSAKVYPAASLPGRAARRGAHLIEFNLEETDY-NQLPNYIFVKG 264 Query: 220 PASQVVPEFVEKLLK 234 P+ Q +P V+++++ Sbjct: 265 PSGQTLPTIVDRVIE 279 >UniRef50_C7RQR7 Silent information regulator protein Sir2 n=1 Tax=Candidatus Accumulibacter phosphatis clade IIA str. UW-1 RepID=C7RQR7_9PROT Length = 253 Score = 125 bits (313), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 87/235 (37%), Positives = 123/235 (52%), Gaps = 15/235 (6%) Query: 6 VLVLTGAGISAESGIRTFR-AADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQ 64 V+V +GAG+SA+SGI TFR A GLW ++VA+ EGF R P +V + + + Sbjct: 19 VVVFSGAGLSADSGIPTFRDGATGLWNNVDPDEVASIEGFLRKPRVVWDWLLQLKNLVD- 77 Query: 65 PEIQPNAAHLALAKLQDAL-GDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRC-SQSG 122 + PNA H A+A+L+D G R ++TQNID H +AGN V+ +HG + +VRC + G Sbjct: 78 -DRHPNAGHEAIARLEDLCKGKRLTIITQNIDGYHTQAGNAQVLEVHGTIHRVRCHRRCG 136 Query: 123 QVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMD-EIYMALSM----ADIFIAIG 177 W C C P+RP +V FGEM +D E++ A + AD+F +G Sbjct: 137 FAAVWEQSAVEPFSCPNCG--GPVRPDLVLFGEM---LDEEVFAAAGIRSLNADLFFCVG 191 Query: 178 TSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 TS V PAA AK GA VE+N P+ + + ASQ +L Sbjct: 192 TSFTVQPAARLPVWAKGAGATVVEVNPHPTPLSDAADYSIRAGASQFFGALCARL 246 >UniRef50_A8NWP2 Putative uncharacterized protein n=1 Tax=Coprinopsis cinerea okayama7#130 RepID=A8NWP2_COPC7 Length = 315 Score = 125 bits (313), Expect = 1e-27, Method: Compositional matrix adjust. Identities = 91/281 (32%), Positives = 127/281 (45%), Gaps = 61/281 (21%) Query: 6 VLVLTGAGISAESG----------------IRTFRAADGLWEEHRVEDVATPEGFDRDPE 49 ++ + GAG+SA SG I TFR A G+W ++ +ATPEGF +P Sbjct: 19 IIAVAGAGLSAASGKSGYYRFKWNLTTSQGIPTFRGAGGMWRKYDAMSLATPEGFADNPS 78 Query: 50 LVQAFYNARRRQLQQPEIQPNAAHLALAKLQD-------ALGDRFLLVTQNIDNLHERA- 101 LV FY+ RR + ++ NAAHLALA A G F L+TQN+D L RA Sbjct: 79 LVWQFYHYRREAALKADV--NAAHLALASFSIPRIRHTVAPGSSFTLITQNVDGLSPRAM 136 Query: 102 --------GNT------NVIHMHGELLKVRCSQSGQV-LDWTGDVT-------------- 132 G T +I MHG L V+C+Q V LD + + Sbjct: 137 KCVLQGWDGVTLPEDPPYLIEMHGRLFDVKCTQCDHVELDTSSPICEGLAGTEKLVEQAV 196 Query: 133 -----PEDKCHCCQFPAPL-RPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGHVYPAA 186 PE+ C+ L RP VVWFGEMP + I + AD+ + +GTS VYPAA Sbjct: 197 LDPEIPEENLPRCKKCGSLARPGVVWFGEMPHDLPLIDTLVEKADLCLVVGTSSTVYPAA 256 Query: 187 GFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPE 227 G+ E +G N E + ++ + G + +P+ Sbjct: 257 GYASEVSANGGKVAVFNYERTMGDDDADFLFLGGCEETLPK 297 >UniRef50_Q607X6 NAD-dependent deacetylase n=2 Tax=Gammaproteobacteria RepID=NPD_METCA Length = 255 Score = 125 bits (313), Expect = 2e-27, Method: Compositional matrix adjust. Identities = 85/239 (35%), Positives = 117/239 (48%), Gaps = 13/239 (5%) Query: 6 VLVLTGAGISAESGIRTFR-AADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQ 64 + V TGAG+SAESGI TFR A G WE + +A+PEGF DP LV +Y RR ++ + Sbjct: 17 IAVFTGAGVSAESGIPTFRDALTGFWENYDASTLASPEGFAADPALVWGWYEWRRTRVLR 76 Query: 65 PEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQV 124 E P +A R L+TQN+D+LHERAG+ + I +HG L RCS Sbjct: 77 AEPNPAHYAIAALAAD---CPRLTLITQNVDDLHERAGSADPIRLHGSLHHPRCSACEAP 133 Query: 125 LDWTGDVTPE-------DKCHCCQFPAPLRPHVVWFGE-MP-LGMDEIYMALSMADIFIA 175 + E D C + AP+RP VVW GE +P D A D+ + Sbjct: 134 YRLPPGIPDEPEGGRRVDPPRCARCGAPVRPGVVWLGENLPQAAWDAARQAAEDCDLMFS 193 Query: 176 IGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLK 234 IGTS V+PAA GA V++N + + G A +V+P ++ L + Sbjct: 194 IGTSALVWPAAQLPALVARRGATVVQVNPAETALDGHAGYNLRGAAGKVMPLLLQALRR 252 >UniRef50_A6Q178 Transcription regulator, Sir2 family n=1 Tax=Nitratiruptor sp. SB155-2 RepID=A6Q178_NITSB Length = 234 Score = 124 bits (311), Expect = 3e-27, Method: Compositional matrix adjust. Identities = 74/182 (40%), Positives = 111/182 (60%), Gaps = 13/182 (7%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQ 64 + +L+GAG+SA SGI TFR GLW+ +++VAT E + ++P+ V AF++ RR +L Sbjct: 10 NIYILSGAGLSAPSGIPTFRDG-GLWDNINIDEVATHEAWLKNPKKVIAFFDQRRIELAH 68 Query: 65 PEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQV 124 QPN AH A L +A+ +TQN+D+L E+AG+ N IH+HG+L ++RC ++ Sbjct: 69 --CQPNRAHYFFASLPNAIH-----LTQNVDDLCEKAGD-NPIHLHGKLTEIRCEVCKKI 120 Query: 125 LDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGHVYP 184 D G + CH C +RP+V+ FGE + + Y+ + ADIFIA+GTSG V Sbjct: 121 WD-IGYTAQPNNCHFCG-SFNVRPNVILFGE--VASNYRYLYTTKADIFIAVGTSGKVID 176 Query: 185 AA 186 A Sbjct: 177 IA 178 >UniRef50_Q6C8C7 YALI0D20724p n=1 Tax=Yarrowia lipolytica RepID=Q6C8C7_YARLI Length = 303 Score = 122 bits (305), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 85/234 (36%), Positives = 118/234 (50%), Gaps = 37/234 (15%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQ 64 ++L L GAG+S SG+ TFR G+W + ++ATPE F DP V FY A RR + Sbjct: 18 KILALVGAGLSQSSGLPTFRGEGGIWRNYDAAELATPEAFHNDPSTVWQFY-AHRRHMSL 76 Query: 65 PEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTN--VIHMHGELLKVRCSQ-- 120 + +PN H ALA+L L RFL +TQN+D L RA + ++ +HG+L ++C+ Sbjct: 77 -KAKPNPGHYALAELARRLRGRFLTLTQNVDGLSSRAEHPQEALLKLHGDLFALKCTSFF 135 Query: 121 -SGQVLDWTGD-VTP--------------------ED--KCHCCQFPAPLRPHVVWFGE- 155 S D D +TP ED C C+ LRP VVWFGE Sbjct: 136 CSYTTEDNFADPLTPALSITDNYNSAQLQRHRIPVEDLPTCPHCK-EGLLRPGVVWFGES 194 Query: 156 MPLGM----DEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLE 205 +P + DE ++ D+ I +GTSG V+PAAG+V L G N+E Sbjct: 195 LPFKVMNTADE-FLEDEDVDLIIVVGTSGSVWPAAGYVERVALSGGKVAIFNME 247 >UniRef50_C5AIV3 Putative uncharacterized protein n=1 Tax=Burkholderia glumae BGR1 RepID=C5AIV3_BURGB Length = 248 Score = 122 bits (305), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 78/211 (36%), Positives = 117/211 (55%), Gaps = 8/211 (3%) Query: 4 PRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQ 63 PR+ V +GAG+SAESGI TFR DG+W ++ V + R+ E V AFYNA R + Sbjct: 11 PRLYVFSGAGLSAESGIPTFRTGDGIWSSANLDKVCNFLTWRRNREAVFAFYNA--RIAE 68 Query: 64 QPEIQPNAAHLALAKLQDALG-DRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG 122 + E +PN AH LA Q+A G +R LVTQNID+L ERAG V+H+HG++ + C+ Sbjct: 69 KREARPNDAHRMLAAWQEAWGTERVRLVTQNIDDLLERAGARQVVHLHGDVHSLLCTACD 128 Query: 123 QVLDWTGDVTPEDK-CHCCQFPAPLRPHVVWFGEMP---LGMDEIYMALSMADIFIAIGT 178 G+ D C C ++P VV+F E + + + + ++ D+F+AIGT Sbjct: 129 CRFPKDGEHYRLDTACPACGDVESVKPGVVFFNEAAPEYVTLHRMQLEMTERDLFVAIGT 188 Query: 179 SGHVY-PAAGFVHEAKLHGAHTVELNLEPSQ 208 + V P + E +L A ++ +PS+ Sbjct: 189 AFQVVGPESLLPRERRLRHARNFLVDPQPSR 219 >UniRef50_D0LVG3 Silent information regulator protein Sir2 n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LVG3_HALO1 Length = 295 Score = 122 bits (305), Expect = 1e-26, Method: Compositional matrix adjust. Identities = 94/272 (34%), Positives = 129/272 (47%), Gaps = 50/272 (18%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEE----HRVEDVATPEGFDRDPELVQAFYNARRRQ 61 LVLTGAGISAESGI TFR DG W + +++AT F+R P+ V +Y RR Sbjct: 27 CLVLTGAGISAESGIPTFRGKDGYWTVGSTVYHPQELATNAAFERLPDEVWQWYLYRRSV 86 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNT--NVIHMHGELLKVRCS 119 ++ QPN AH AL L+ LGD FLL+TQN+D LH RAG + +HG++ +RC+ Sbjct: 87 CRR--AQPNPAHDALVTLEQHLGDAFLLITQNVDGLHPRAGQSRARTYSVHGDIDLMRCA 144 Query: 120 Q----------------SGQVLDWTGDV------TPEDKCH-----CCQFPAPLRPHVVW 152 SGQ +G V P D+ C + RPHV+W Sbjct: 145 AGCSAELLPVPDQAWPVSGQAWPVSGQVGEIDAGQPLDEAQRQLLRCPRCGGRTRPHVLW 204 Query: 153 FGEMPLGMDEIYM-------ALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNL- 204 F E DE Y A + A + + +GTS V A+ HGA +++NL Sbjct: 205 FDEY---YDEAYFRFHSSRDAATRAALLLIVGTSASTNLPWQVVTLAQQHGATIIDINLE 261 Query: 205 ----EPSQVGNEFAEKYYGPASQVVPEFVEKL 232 EP+ + + PA+ V+P V L Sbjct: 262 SNPFEPAALASPGGAVIRQPATAVLPPLVAAL 293 >UniRef50_C5CY53 Silent information regulator protein Sir2 n=1 Tax=Variovorax paradoxus S110 RepID=C5CY53_VARPS Length = 249 Score = 121 bits (304), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 85/229 (37%), Positives = 112/229 (48%), Gaps = 14/229 (6%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQ 64 R+ VL+GAG+S SGI T+R ADGLW + E RDP F+ RR Sbjct: 26 RIAVLSGAGLSKASGISTYRDADGLWMNQNALQFSHAEDLQRDPRRFTRFWA--RRLSTV 83 Query: 65 PEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQV 124 QPN H ALA LQ L LVTQN+D L AG +V+ +HG L + RC G Sbjct: 84 EAAQPNPGHAALALLQR-LRPATRLVTQNVDGLLSIAGGLDVLELHGSLRRWRCDHCGNR 142 Query: 125 LD-WTGDVTPEDKCHCCQFPAPLRPHVVWFGEM--PLGMDEIYMALSMADIFIAIGTSGH 181 W P +C C A RP VV FGEM P + + +A +D+F+ +G++ Sbjct: 143 RGPW-----PFHRCMRCASRA--RPDVVMFGEMLNPGVLHDAQVAAQESDVFMVVGSTAV 195 Query: 182 VYPAAGFVHEAKLHGAHTVELNLEP-SQVGNEFAEKYYGPASQVVPEFV 229 VYPAA A GA + LN+EP Q+ A G A ++P + Sbjct: 196 VYPAAELPQLAMSRGARLITLNMEPLPQLDAAAAVVLRGAAEVLLPRLL 244 >UniRef50_Q8NSM4 NAD-dependent deacetylase n=15 Tax=Corynebacterium RepID=NPD_CORGL Length = 258 Score = 121 bits (304), Expect = 2e-26, Method: Compositional matrix adjust. Identities = 85/249 (34%), Positives = 133/249 (53%), Gaps = 21/249 (8%) Query: 2 EKPRVLVLTGAGISAESGIRTFRA-ADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 E + V TGAG+SA+SG+ T+R GLW + +A+ + + +DPE + A+Y R R Sbjct: 19 EARNIEVFTGAGMSADSGLETYRDDKTGLWSNVDPQAMASIDAWRKDPEPMWAWY--RWR 76 Query: 61 QLQQPEIQPNAAHLALAKLQDA-LGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCS 119 +PNA H A++ + + + + TQNIDNLHERAG+++V H+HG L + RCS Sbjct: 77 AGVAARAEPNAGHQAISYWEGSDTVEHVHITTQNIDNLHERAGSSDVTHLHGSLFEYRCS 136 Query: 120 QSGQVLDWTGDVT-PEDKC------HCCQFPAPLRPHVVWFGEMPLGMDEIYMA---LSM 169 W D P++ C + +RP VVWFGE L ++E +A ++ Sbjct: 137 DCA--TPWEDDKNYPQEPIARLAPPQCEKCGGLIRPGVVWFGEN-LPVEEWDIAEQRIAE 193 Query: 170 ADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFV 229 AD+ I +GTSG V+PAA A+ G VE++ +++ + A+Q +P Sbjct: 194 ADLMIIVGTSGIVHPAAALPQLAQQRGVPIVEISPTRTELSRIADFTWMSTAAQALP--- 250 Query: 230 EKLLKGLKA 238 L++GL A Sbjct: 251 -ALMRGLSA 258 >UniRef50_A8MBU4 NAD-dependent deacetylase n=14 Tax=cellular organisms RepID=NPD_CALMQ Length = 257 Score = 120 bits (302), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 87/239 (36%), Positives = 126/239 (52%), Gaps = 15/239 (6%) Query: 7 LVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQPE 66 + TGAGIS ESGI FR GLW +A+ + + DP+ FY R R L Sbjct: 24 IAFTGAGISTESGIPDFRGPQGLWRRFD-PALASIDYLNTDPKGFWEFYIERFRVLNNA- 81 Query: 67 IQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVLD 126 +PN AHLALA+L+ LG ++TQNIDNLH+ AG+ NVI +HG V C + Sbjct: 82 -RPNKAHLALAELEK-LGIIKYVITQNIDNLHQSAGSINVIELHGNYTTVYCMRCKTQYP 139 Query: 127 WTGDVTP----EDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMA---DIFIAIGTS 179 +T + E+ C + LRP+VV FGE ++EI AL +A D+ + +G+S Sbjct: 140 FTLALRKYEEGENPPRCPKCGGILRPNVVLFGE---PVNEINRALEIAALSDVALVVGSS 196 Query: 180 GHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKGLKA 238 VYPAA K HG + +NLEP+ +++A+ ++ + V +KG+ A Sbjct: 197 LTVYPAAYVPLVVKEHGGRLIIINLEPTDY-DDYADVVLHCSASEALDLVLNEVKGIMA 254 >UniRef50_B2ARI4 Predicted CDS Pa_4_7390 (Fragment) n=1 Tax=Podospora anserina RepID=B2ARI4_PODAN Length = 344 Score = 120 bits (302), Expect = 3e-26, Method: Compositional matrix adjust. Identities = 92/274 (33%), Positives = 129/274 (47%), Gaps = 49/274 (17%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQ 64 R+L + GAG+SA SG+ TFR A GLW H D+ATPE FD DP LV FY RR Sbjct: 62 RILAVCGAGLSAASGLPTFRGAGGLWRNHNAVDLATPEAFDADPGLVWLFYAYRRHMALT 121 Query: 65 PEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTN--VIHMHGELLKVRCSQSG 122 +PN AH ALA+L F ++QN+DNLH RA + + + +HG L ++C+ Sbjct: 122 --AKPNPAHYALAELARKRPG-FKCLSQNVDNLHVRANHPSDQLSLLHGSLFTLKCTTCS 178 Query: 123 -----------------------------QVLDWT---GDVTPEDKCHCCQFPAPL-RPH 149 +LD ++ + HC L RP Sbjct: 179 WKDLYNIADPLCPALAPAAESNPDPTKPLPLLDPAQPLAEIKESELPHCPDCKTELQRPG 238 Query: 150 VVWFGEMPLGMD-----EIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHG-AHTVELN 203 VVWFGEM L D E ++ D+ + +GTS VYPAAG+ A+ G V +N Sbjct: 239 VVWFGEM-LDEDMLDDIEEWIEKEPVDMVLVVGTSSAVYPAAGYAERARTKGRTSVVTVN 297 Query: 204 LEPSQVGNEFAEK----YYGPASQVVPEFVEKLL 233 LE ++ K + G AS ++PE + ++ Sbjct: 298 LEITEEDWGRMRKGDFGFEGDASLLLPELLRPVI 331 >UniRef50_A9DQY7 Silent information regulator protein Sir2 n=1 Tax=Kordia algicida OT-1 RepID=A9DQY7_9FLAO Length = 276 Score = 120 bits (300), Expect = 5e-26, Method: Compositional matrix adjust. Identities = 75/231 (32%), Positives = 117/231 (50%), Gaps = 25/231 (10%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLW----EEHRVEDVATPEGFDRDPELVQAFYNA 57 ++ + LTGAG+SA SGI T+R+ DG+W + H+ E+ T F ++ E V F Sbjct: 16 KRNNITFLTGAGLSAASGIPTYRSTDGIWVKGTKYHKPEEFGTFSYFSKNQEEVWQFNLF 75 Query: 58 RRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNT--NVIHMHGELLK 115 R+ Q+ QPN +H LAK++ + + F ++TQNID LH+R GN+ V +HG + Sbjct: 76 RKGMFQKA--QPNDSHKLLAKIEKLIPEEFSIITQNIDGLHQRGGNSGNKVFEIHGNMRT 133 Query: 116 VRCSQ--SGQVLDWTGDVTPE-----------DKCHCCQFPAPLRPHVVWF----GEMPL 158 VRCS S V + D+T + DK C + A +RP+++WF E Sbjct: 134 VRCSLECSKAVYLYPKDITIDRIDQDLTDDIWDKLECPKCGAVMRPNILWFDEYYNERLY 193 Query: 159 GMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQV 209 +D I I IGTSG V + +G + +++NLE + + Sbjct: 194 KVDSTMRIAKNTGILIVIGTSGATTLPLELVKQTLKYGGYVLDVNLEDNNI 244 >UniRef50_B8F955 Silent information regulator protein Sir2 n=1 Tax=Desulfatibacillum alkenivorans AK-01 RepID=B8F955_DESAA Length = 246 Score = 120 bits (300), Expect = 6e-26, Method: Compositional matrix adjust. Identities = 78/231 (33%), Positives = 125/231 (54%), Gaps = 8/231 (3%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQP 65 V+ LTGAG+S ESGI FR GLWE+ ++A + F +PE V A + + Sbjct: 18 VVALTGAGVSVESGIPPFRGKGGLWEKFDPMEIAHIDSFLANPERVWRILVAEMKGVID- 76 Query: 66 EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVL 125 + QPN H LA+L++ G+ ++TQN+D LH+ AG+ +VI HG + RC + Sbjct: 77 KAQPNNLHKGLARLEET-GNLAAIITQNVDGLHQAAGSKDVIEFHGTFAEQRCMDCEAKI 135 Query: 126 DWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMA---DIFIAIGTSGHV 182 T +V+ E C LRP V+FGEM + + ++ + +A D+ + +GTS V Sbjct: 136 P-TSEVSLEVIPPRCSCGGMLRPDCVFFGEM-IPSEALWRSKELAEQCDVMMVVGTSAIV 193 Query: 183 YPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAE-KYYGPASQVVPEFVEKL 232 PAA AKL GA +E+N+E + + A+ +G A +++ +E++ Sbjct: 194 EPAASMARIAKLGGATVIEMNMERTMLTGRVADYSLFGGAGKLMTGILEEM 244 >UniRef50_A8VRI8 NAD-dependent protein deacetylase SIR2 family-like protein n=1 Tax=Bacillus selenitireducens MLS10 RepID=A8VRI8_9BACI Length = 235 Score = 119 bits (299), Expect = 7e-26, Method: Compositional matrix adjust. Identities = 83/227 (36%), Positives = 119/227 (52%), Gaps = 15/227 (6%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQP 65 V+VLTGAG+S ES I FR+ G W++ +ATPE + +PE +AFY AR L++ Sbjct: 14 VVVLTGAGMSTESNIPDFRSRSGWWQQVDPMTIATPEALEGNPEQFKAFYKARLEALEEA 73 Query: 66 EIQPNAAHLALAKLQD-ALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQV 124 E PN H +A+ ++ L DR + TQN+D LH+RAG+ NV +HG + +RC + + Sbjct: 74 E--PNRGHQIIARWEERGLVDR--VATQNVDGLHQRAGSRNVDALHGTIHAIRCHRCDRP 129 Query: 125 LDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSM---ADIFIAIGTSGH 181 + + E C LRP VV FGEM L D AL AD+ + IGTS Sbjct: 130 HELDAFLRDE---ACVSCGGVLRPGVVLFGEM-LPQDAWQRALKAIEKADVVLVIGTSLD 185 Query: 182 VYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEF 228 VYP + G TV +N + Q + F + G A +++ E Sbjct: 186 VYPVNQL---PSVTGGKTVYINRDIDQSIHAFDAVHQGSAGEILEEL 229 >UniRef50_Q5WKC8 NAD-dependent deacetylase n=7 Tax=Bacillaceae RepID=NPD_BACSK Length = 237 Score = 119 bits (297), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 77/202 (38%), Positives = 111/202 (54%), Gaps = 10/202 (4%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQ 64 R++V TGAG+S ESG+ FR++ GL + + E +A+ + + + E FY R QLQ Sbjct: 11 RIVVFTGAGMSTESGVPDFRSSRGLCKGNNPEALASLQAMNDNREAFVDFYRRRMEQLQH 70 Query: 65 PEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQV 124 +QP+ + LA + L ++TQN D LHERAGN V+ +HG + K+ C Q GQ Sbjct: 71 --VQPHKGYDVLATWEQQLSVT-AIITQNTDGLHERAGNQRVLPLHGSIQKLYCIQCGQH 127 Query: 125 LDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSM---ADIFIAIGTSGH 181 D + + C C F +RP VV FGE PL + + +A AD+FI +G+S Sbjct: 128 YDVDRYMNNQPSCSCGGF---IRPSVVLFGE-PLDSNILALAEQHSIEADVFIVLGSSLV 183 Query: 182 VYPAAGFVHEAKLHGAHTVELN 203 V PA F AK HGA + +N Sbjct: 184 VSPANLFPRIAKEHGAKLIIVN 205 >UniRef50_B8JAI9 Silent information regulator protein Sir2 n=5 Tax=Myxococcales RepID=B8JAI9_ANAD2 Length = 279 Score = 119 bits (297), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 89/233 (38%), Positives = 117/233 (50%), Gaps = 30/233 (12%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLW----EEHRVEDVATPEGFDRDPELVQAFYNARRR 60 +V+ LTGAGISAESGI TFR A+G W + +++AT E F+ P+ V +Y R Sbjct: 26 KVVALTGAGISAESGIPTFRGAEGYWVVGSRNYMPQEMATREMFEAAPDEVWRWYLYRFG 85 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 + + +PN H AL +L+ ALG+RF LVTQNID LH RAG+ V +HG+ VRC+ Sbjct: 86 VCR--DARPNPGHEALVRLEAALGERFTLVTQNIDGLHRRAGSRRVFCIHGDAAYVRCAA 143 Query: 121 SGQV--LD------------WTGDVTPEDKCHCCQFPAPLRPHVVWFGEM----PLGMDE 162 V LD +T + C C LRPHV+WF E MD Sbjct: 144 ECGVGLLDLPAMAPRRKDDPFTERERSQLSCPACG--GWLRPHVLWFDEYYDEANYRMDS 201 Query: 163 IYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAE 215 A AD+ + +GTSG A GA V++N E N FAE Sbjct: 202 AVRAAEAADLLLVVGTSGATNLPMQIGRIAFHRGAALVDVNPEE----NPFAE 250 >UniRef50_B0D7T5 Predicted protein n=3 Tax=Agaricales RepID=B0D7T5_LACBS Length = 332 Score = 117 bits (293), Expect = 4e-25, Method: Compositional matrix adjust. Identities = 85/266 (31%), Positives = 121/266 (45%), Gaps = 47/266 (17%) Query: 5 RVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQ 63 +L+L+GAG+SA SGI T+R+AD LW ATP+ F +DP V +Y+ RR++ Sbjct: 56 NILILSGAGLSAASGIPTYRSADESLWNNFDPTAYATPQAFAKDPSGVWRWYHNRRKEYL 115 Query: 64 QPEIQPNAAHLALAKLQ--DALG-------DRFLLVTQNIDNLHERAGNT-------NVI 107 + +PN AH ALA L AL + L +TQN+D+L R + +I Sbjct: 116 K--AKPNNAHRALATLALPSALSRIAPCSMSQPLHITQNVDSLSLRLLESLSPEAAEGLI 173 Query: 108 HMHGELLKVRCSQSGQV-----------LDWTGDVTPEDKCHCCQFPAP----------- 145 MHG + +C+ +V LD D + CQ P Sbjct: 174 EMHGSIFVTKCTSCQKVMRSYAPSLASALDGDEDSNAKRDVPLCQLPKCGGDSWAGSNRY 233 Query: 146 ------LRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHT 199 LRP VVWFGEMP M E+ +S D+ + +GTS V PA+ F + K +G Sbjct: 234 GNCGGLLRPEVVWFGEMPPLMGEVSRKMSQCDLLLVVGTSSTVLPASSFATQVKANGGKV 293 Query: 200 VELNLEPSQVGNEFAEKYYGPASQVV 225 NL S +E + GP + Sbjct: 294 AVFNLNRSTGDDEADFLFLGPCETTL 319 >UniRef50_A3LRA1 Transcriptional regulatory protein n=4 Tax=Saccharomycetales RepID=A3LRA1_PICST Length = 311 Score = 117 bits (292), Expect = 4e-25, Method: Compositional matrix adjust. Identities = 77/264 (29%), Positives = 120/264 (45%), Gaps = 67/264 (25%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQ 64 +++ L GAG+S SG+ TFR + GLW+ + D+ATP+ F DP LV FY+ RR Q Sbjct: 17 KIVALVGAGLSVSSGLPTFRGSQGLWKNFNMIDLATPDAFYIDPGLVWQFYSWRRYNALQ 76 Query: 65 PEIQPNAAHLALAKLQDALGDR-----FLLVTQNIDNLHERAGNT--NVIHMHGELLKVR 117 +PN HLAL+ L + + ++ +TQN+D L R+G+ N+ +HG L + Sbjct: 77 A--KPNKGHLALSALSNLATRKDSNLEYITITQNVDGLSSRSGHAKENLYEIHGSLFNLN 134 Query: 118 CSQ---------------------------------------SGQVLDWTGDVTPE---- 134 C+ S +D++ ++P+ Sbjct: 135 CTSFMCNYVDRNNLKHPLTKALEGTEYEYDRKNRKRSLEEDDSSHQVDYS--ISPQFRPV 192 Query: 135 --------DKCHCCQFPAPLRPHVVWFGE-MPLG----MDEIYMALSMADIFIAIGTSGH 181 +C C+ + LRP VVWFGE +PL +D + + D+ + IGTSG Sbjct: 193 KNIPESELPQCPVCKDGSLLRPGVVWFGESLPLNVMNSVDNFIESNNSVDLILVIGTSGT 252 Query: 182 VYPAAGFVHEAKLHGAHTVELNLE 205 VYPA +V K+ G N + Sbjct: 253 VYPANSYVDRVKVKGGKVAIFNTD 276 >UniRef50_Q8ZU41 NAD-dependent deacetylase 1 n=4 Tax=Pyrobaculum RepID=NPD1_PYRAE Length = 254 Score = 116 bits (291), Expect = 6e-25, Method: Compositional matrix adjust. Identities = 88/245 (35%), Positives = 126/245 (51%), Gaps = 38/245 (15%) Query: 7 LVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNA--------R 58 + LTGAG+S SGI FR G+W RV+ PE F+ + FYN Sbjct: 24 VALTGAGVSTASGIPDFRGPQGVW--RRVD----PEKFE-----ISYFYNNPDEVWDLFV 72 Query: 59 RRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRC 118 + L ++PN AH ALA+++ LG ++TQN+D LH+ AG+ NVI +HG L C Sbjct: 73 KYLLPAFNVKPNPAHYALAEMER-LGKLCAVITQNVDRLHQAAGSKNVIELHGALEYAVC 131 Query: 119 SQSG------QVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMD---EIYMALSM 169 + G + L W P +C C ++P VV+FGE PL D E +M M Sbjct: 132 TNCGSKYALAEALKWRKSGAP--RCPKCG--GVIKPDVVFFGE-PLPQDALREAFMLAEM 186 Query: 170 ADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYY--GPASQVVPE 227 A++F+AIGTS VYPA AK GA V +N + + +F Y G A +V+P+ Sbjct: 187 AEVFMAIGTSLAVYPANQLPLVAKKRGAKLVIINADETYY--DFFADYIIRGRAEEVLPK 244 Query: 228 FVEKL 232 +++L Sbjct: 245 LLDRL 249 >UniRef50_Q75DM1 ABL004Wp n=1 Tax=Eremothecium gossypii RepID=Q75DM1_ASHGO Length = 319 Score = 116 bits (291), Expect = 6e-25, Method: Compositional matrix adjust. Identities = 92/294 (31%), Positives = 138/294 (46%), Gaps = 69/294 (23%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQ 64 ++L + GAG+SA SG+ TF+AA G W H ++ATPE F +PELV FY+ARR + Sbjct: 20 KILCIVGAGLSASSGLTTFQAAHGEWRGHSALELATPEAFQENPELVWVFYSARRYTAMK 79 Query: 65 PEIQPNAAHLALAKL--QDALGDR--FLLVTQNIDNLHERAGN--TNVIHMHGELLKVRC 118 +PN H ALA+L + A +R LLVTQN+D LH RAG + + +HG + RC Sbjct: 80 --ARPNNGHFALAELCRRVAADERREILLVTQNVDGLHWRAGQPEASTVELHGSVFDYRC 137 Query: 119 SQSGQVLDWTGDVT-------------------------PEDK--CHCCQ-FPAPLR--- 147 ++ + + G PE+K H C+ P LR Sbjct: 138 TEF--LCSYRGRNVRDHFLTAGLRAHTPRELPRPAAAEEPENKRAKHACEGTPETLRSRL 195 Query: 148 -------------------PHVVWFGE--MPLGMDEIYMALSM---ADIFIAIGTSGHVY 183 P VVW GE + MD + LS D+ + IGTSG ++ Sbjct: 196 DMLRGDLPRCPRCRVGLLRPGVVWCGESLSLVQMDRVDAFLSAKQKVDLVLVIGTSGRLW 255 Query: 184 PAAGFVHEAKLHGAHTVELNLEPSQVG----NEFAEKYYGPASQVVPEFVEKLL 233 PA G+V A+L G+ N + N+ + G A++++P+ +E ++ Sbjct: 256 PAMGYVERAQLCGSRIAFFNTDIEDAAGVAKNKRMWAFQGNAAELLPQALEPVI 309 >UniRef50_Q2YZT2 Putative uncharacterized protein n=1 Tax=uncultured delta proteobacterium RepID=Q2YZT2_9DELT Length = 254 Score = 115 bits (289), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 79/213 (37%), Positives = 111/213 (52%), Gaps = 8/213 (3%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQP 65 V+ +TGAGIS ESGI FR+ GLW + A + F RDP V L Q Sbjct: 18 VIAMTGAGISVESGIPDFRSPGGLWSRFDPFEYAHIDAFKRDPAKVWKMLLEIDEVLNQA 77 Query: 66 EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVL 125 +PN AH ALAKL+ A G ++TQNIDN+H+RAG+ NVI HG + C++ + Sbjct: 78 --KPNRAHYALAKLE-AAGILKAIITQNIDNMHQRAGSKNVIEFHGNAETLTCTKCKKKF 134 Query: 126 DWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMA---LSMADIFIAIGTSGHV 182 ++T E C+ +RP VV+FGE + MA + + + IGTS V Sbjct: 135 TRE-EITMESIPPLCECKGVIRPDVVFFGET-IPAHATRMAGKEVEKCAMILVIGTSADV 192 Query: 183 YPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAE 215 PA+ +AK GA VE+NL +++ A+ Sbjct: 193 APASRLPIKAKEGGAIIVEINLRETRLITPIAD 225 >UniRef50_A6LP94 Silent information regulator protein Sir2 n=1 Tax=Thermosipho melanesiensis BI429 RepID=A6LP94_THEM4 Length = 234 Score = 115 bits (288), Expect = 1e-24, Method: Compositional matrix adjust. Identities = 78/235 (33%), Positives = 125/235 (53%), Gaps = 17/235 (7%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 +E+ V+ LTGAGIS SGI FR+ DGL++E+ E + + E F P++ FY ++ Sbjct: 9 LEEGNVVALTGAGISTSSGIPDFRSEDGLYKEYGYE-LFSYEFFKNHPDI---FYEYIKK 64 Query: 61 QL-QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCS 119 + + + N +H LA+L++ +G ++TQNID+LH +AG+ NVI +HG C Sbjct: 65 EFPKMYKANYNMSHKLLAELEE-MGYLLGVITQNIDDLHNKAGSRNVIELHGNATHFYCE 123 Query: 120 QSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTS 179 + + + K + C +RP +V+FGE +D ++ L A+ + +GTS Sbjct: 124 ECERKYSFP-------KEYICSCGGLIRPDIVFFGEPVNDIDRVFELLDKAETLLVMGTS 176 Query: 180 GHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLK 234 VYPA+ F K G + +N E +Q N FA+ V EF +K+LK Sbjct: 177 LQVYPASNFPVYVKERGGILIIVNREETQYDN-FAD---FVLHMNVEEFSKKVLK 227 >UniRef50_A9A0B2 NAD-dependent deacetylase n=1 Tax=Desulfococcus oleovorans Hxd3 RepID=NPD_DESOH Length = 273 Score = 115 bits (287), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 88/263 (33%), Positives = 127/263 (48%), Gaps = 35/263 (13%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGF----DRDPELVQAFYNARRR 60 R V +GAG+SAESGI TFR G+W+ +V +G +++PE + A + Sbjct: 19 RAAVFSGAGVSAESGIPTFRDPGGVWDRLNPAEVGDTQGLLASLEKNPEKLVAMFMELLA 78 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 PN H AL L+ +G ++TQNIDNLH+ AGNT VI MHG + RC + Sbjct: 79 VFDAA--IPNPGHRALFDLER-MGILQAVITQNIDNLHQEAGNTQVIEMHGNGFRFRCLK 135 Query: 121 S------------GQV---LDWTGDVTPED------KCHCCQFPAPLRPHVVWFGEMPLG 159 G+V L D +P C C + +RP VV FGE + Sbjct: 136 CRSRRSHERHALIGRVKERLSTLPDFSPASIFAAMPDCDLCG--SGMRPDVVMFGETVME 193 Query: 160 MDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYY- 218 ++ + A D+ +A+GTSG V PAA EAK GA + +N P++ G Y Sbjct: 194 VENAFAAARSCDVMLALGTSGVVTPAAQIPAEAKASGAKVIVIN--PNENGFARVCDIYI 251 Query: 219 -GPASQVVPEFVEKLLKGLKAGS 240 Q +P VE+ +K +++GS Sbjct: 252 SMKTGQALPRIVEQ-VKKIRSGS 273 >UniRef50_A1ZHW6 NAD-dependent deacetylase n=2 Tax=Microscilla marina ATCC 23134 RepID=A1ZHW6_9SPHI Length = 279 Score = 115 bits (287), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 82/258 (31%), Positives = 129/258 (50%), Gaps = 32/258 (12%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWE----EHRVEDVATPEGFDRDPELVQAFYNA 57 ++ +++VLTGAGISAESGI TFR +G W+ ++ +++ T + F ++P+ V +Y Sbjct: 17 DQAKMVVLTGAGISAESGIPTFRGKEGYWKIGSVNYQPQEIGTMKMFKQNPQEVWKWYLF 76 Query: 58 RRRQLQQPEIQPNAAHLALAKLQDAL-GDRFLLVTQNIDNLHERAGNT--NVIHMHGELL 114 R QPN H A+A+++ L G RF LVTQN+D LH RAG+T N + +HG+L Sbjct: 77 RHTVCNNS--QPNPGHYAVAEMEKILGGKRFTLVTQNVDGLHFRAGSTFKNTLLIHGDLT 134 Query: 115 KVRCSQSG---QVLDWTGDVTPE-----------DKCHCCQFPAPLRPHVVWFGEMPLGM 160 VRCS+ ++L + + P+ ++ C A RPHV+WF E Sbjct: 135 HVRCSKDSCDTELLPFPEGIAPKTRESAISLEEWERLRCPSCGALTRPHVLWFDEYYNEK 194 Query: 161 DEIYMAL----SMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQV-----GN 211 Y AD+ I +GTSG + A + V +NL+ S N Sbjct: 195 YYKYETALHKNREADLLIVVGTSGATNLPNKMYYNALNNNKQIVVVNLDSSIFSRTLEAN 254 Query: 212 EFAEKYYGPASQVVPEFV 229 + G + +++PE + Sbjct: 255 QTGHVLLGKSGEILPEIL 272 >UniRef50_C5L233 NAD-dependent deacetylase sirtuin-5, putative n=2 Tax=Perkinsus marinus ATCC 50983 RepID=C5L233_9ALVE Length = 253 Score = 115 bits (287), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 86/229 (37%), Positives = 111/229 (48%), Gaps = 41/229 (17%) Query: 2 EKPRVLVLTGAGISAESGIRTFRA--ADGLWEEHR-VEDVATPEGFDRDPELVQAFYNAR 58 E ++V+TGAG+SAESGI TFR GLW+E+ +ATPE F +P LV FY R Sbjct: 17 EAHHIVVITGAGVSAESGIPTFRGPGGGGLWQEYDDPTRLATPEAFAANPSLVWEFYEYR 76 Query: 59 RRQLQQPEIQPNAAHLALAKLQ---DALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLK 115 R+ + PN H+ A+LQ + G F L+TQN+D LH+ AG+ N+I +HG L Sbjct: 77 RKVVAA--ASPNTCHMWCAELQKIKENDGKDFTLMTQNVDRLHQAAGSHNIIELHGSLWL 134 Query: 116 VRCSQSGQ---------VLDWTGDVT-----------PEDKCHCCQFPAP---------L 146 V+ S V W P D H P L Sbjct: 135 VKKSSDAAHTHTFIEDGVNVWEDRNVPITPAFANIDQPPDHHHHITVPIGELPHRDGRLL 194 Query: 147 RPHVVWFGEMPLGMDEI---YMALSMADIFIAIGTSGHVYPAAGFVHEA 192 RP VVWFGE L D + A+S D+ + +GTS VYPAAGF A Sbjct: 195 RPAVVWFGEA-LDKDTLASANKAMSSCDLLLVLGTSSVVYPAAGFADTA 242 >UniRef50_C4DIV4 NAD-dependent protein deacetylase, SIR2 family n=1 Tax=Stackebrandtia nassauensis DSM 44728 RepID=C4DIV4_9ACTO Length = 248 Score = 115 bits (287), Expect = 2e-24, Method: Compositional matrix adjust. Identities = 86/238 (36%), Positives = 116/238 (48%), Gaps = 17/238 (7%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 E RV+VLTGAGIS SG+ T+R DG W + A + D V + Sbjct: 14 EYSRVVVLTGAGISRPSGLPTYRGDDGTWNDPEAARAAEADTVGTDLAAVWRLWGGLAHL 73 Query: 62 LQQPEIQPNAAHLALAKLQDALGDR---FLLVTQNIDNLHERAGNTNVIHMHGELLKVRC 118 QPN AH ALA +++L R L+VTQN+D LH+R G +VI +HG + RC Sbjct: 74 AAA--AQPNPAHRALAGAEESLLARTASLLVVTQNVDGLHQRGGQRDVIELHGNAHRQRC 131 Query: 119 SQSGQVL----DWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSM---AD 171 +G L TG+ P C C A RP +V FGE L ++++ A + AD Sbjct: 132 LDAGCALVAPYVGTGETIP--SCAGCGGRA--RPDIVLFGEQ-LDLEDLERAWNTAAEAD 186 Query: 172 IFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFV 229 + +A+GTS V PAA V A+ GA V L EP F G A + +P +V Sbjct: 187 LLLAVGTSCGVSPAANLVAVARQAGALCVALTREPLPFNPGFHAAVTGLAERELPRWV 244 >UniRef50_C5GPX3 SIR2 family histone deacetylase n=2 Tax=Ajellomyces dermatitidis RepID=C5GPX3_AJEDR Length = 341 Score = 114 bits (285), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 86/273 (31%), Positives = 120/273 (43%), Gaps = 46/273 (16%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQ 64 R+L L GAG+SA SGI T+ W H V + T F DP V FY+ RRR + Sbjct: 64 RILTLLGAGLSAASGIGTYVDEGRFWRTHNVRRLCTYGAFREDPSRVWWFYSDRRRGAMK 123 Query: 65 PEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGN--TNVIHMHGELLKVRCSQSG 122 E PN AH ALAKL LG+ L V QNID L RAG T+ +++HG+ ++CS Sbjct: 124 AE--PNKAHYALAKLARKLGNGMLTVCQNIDRLCPRAGQPETSTVYLHGDYFTIKCSSES 181 Query: 123 QVLDWTGDVTP-------------------------EDKCHCCQFPAPLRPHVVWFGE-M 156 D P E C + LRP V WFGE M Sbjct: 182 CTYSRADDNDPIVPALTLPSTHSISDPDFPLPHVPEESLPRCPSCSSLLRPGVTWFGETM 241 Query: 157 PLG-----------MDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLE 205 P +D + D+ + IGT+ V+P V +A+ GA +N + Sbjct: 242 PPAQTKRVHDWLQQIDRDPESNGHIDLVLVIGTAATVHPVLSLVTQARKKGAKVCVVNPD 301 Query: 206 ---PSQVG--NEFAEKYYGPASQVVPEFVEKLL 233 +VG +E + G A +V+PE ++++ Sbjct: 302 RESAQKVGGMDEGNWWFRGGAEEVLPEIFKEVI 334 >UniRef50_B9L9A0 NAD-dependent deacetylase n=4 Tax=Bacteria RepID=B9L9A0_NAUPA Length = 248 Score = 113 bits (282), Expect = 6e-24, Method: Compositional matrix adjust. Identities = 79/247 (31%), Positives = 129/247 (52%), Gaps = 33/247 (13%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEH--RVEDVATPEGFDRDPE-----LVQAFYNA 57 + + TGAGIS ESGI TFR +GLW ++ ++ D+ + F +P+ + + FY+ Sbjct: 17 KAVAFTGAGISVESGIPTFRGPNGLWSKYDPKILDI---DYFTLNPKDAWEKIKEIFYDY 73 Query: 58 RRRQLQQPEIQPNAAHLALAKLQDALGDRFL--LVTQNIDNLHERAGNTNVIHMHGELLK 115 + I+PN AH LA L+ ++ L ++TQNIDNLH+ AG+ NVI HG Sbjct: 74 MQN------IKPNDAHYFLADLE---KEKMLEAVITQNIDNLHQEAGSKNVIEFHGTAKN 124 Query: 116 VRCSQSGQVLDWT----GDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMA- 170 + C + D D+ P C + L+P+ V+F E P+ + +L +A Sbjct: 125 LVCMNCFKKYDKDVVDLNDLPP----ACPKCWGLLKPNFVFFKE-PIPKKALEKSLELAQ 179 Query: 171 --DIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEF 228 D+ + IGT+G + PA+ AK +GA +E+N+EPS N + + + V + Sbjct: 180 DCDLMLVIGTTGEIQPASQIPILAKENGAKIIEINIEPSNYTNTITDIFLQDKATVASKK 239 Query: 229 VEKLLKG 235 +++ LKG Sbjct: 240 LKEELKG 246 >UniRef50_A4J646 Silent information regulator protein Sir2 n=2 Tax=Peptococcaceae RepID=A4J646_DESRM Length = 256 Score = 112 bits (281), Expect = 8e-24, Method: Compositional matrix adjust. Identities = 80/234 (34%), Positives = 125/234 (53%), Gaps = 20/234 (8%) Query: 5 RVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQ 63 + + LTGAGIS ESGI FR+ + GLW ++ ++VA+ + ++PE +FY + Sbjct: 19 KTIALTGAGISTESGIPDFRSKNTGLWNQYDPQEVASIQALKKNPE---SFYALNFQWWD 75 Query: 64 QP-EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG 122 + +PN AH ALA+L + +G ++TQNID LH+ AG+ V +HG L C Sbjct: 76 VCLKAKPNNAHFALARL-EKMGWLLGVITQNIDGLHQHAGSKRVWEVHGNLKGCSCLSCK 134 Query: 123 QVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGE-MPLGMDEIYMA---LSMADIFIAIGT 178 + D G + + +C C LRP VV FG+ MP ++ +MA +S + + IG+ Sbjct: 135 KQFD-MGQLHKQLRCPFC--GGLLRPDVVLFGDAMP---EDFFMAEKVMSGCQLLLVIGS 188 Query: 179 SGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 S VYP A + + TV +N EP+ ++ PASQV+ + V+ L Sbjct: 189 SLQVYPVASLPQLS----SKTVIINKEPTTWDKHSDVVFHEPASQVLCDLVDSL 238 >UniRef50_A0LG97 Silent information regulator protein Sir2 n=1 Tax=Syntrophobacter fumaroxidans MPOB RepID=A0LG97_SYNFM Length = 248 Score = 112 bits (280), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 78/202 (38%), Positives = 101/202 (50%), Gaps = 10/202 (4%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQP 65 +VLTGAGIS ESGI FR+ DGLW ++ + F +P V L+Q Sbjct: 17 TVVLTGAGISVESGIPDFRSKDGLWSKYDPAEYGYIGSFRANPAKVWTMLTEMDAVLRQA 76 Query: 66 EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVL 125 +PN AHLALA L+ G LVTQNID+LH+RAG+ NVI HG +RC + +V Sbjct: 77 --RPNFAHLALADLEKR-GIVKELVTQNIDSLHQRAGSKNVIEFHGHNRSLRCDRCQKVY 133 Query: 126 --DWTGDVTPEDKCHCCQFPAPLRPHVVWFGE--MPLGMDEIYMALSMADIFIAIGTSGH 181 + T C C LRP +V+FGE P A D + +GTS Sbjct: 134 ARESVSLATLPPACACGN---ALRPEIVFFGEDIPPQAYRSALNAAQKCDFMMIVGTSAS 190 Query: 182 VYPAAGFVHEAKLHGAHTVELN 203 V PA+ AK GA +E+N Sbjct: 191 VAPASQLPLVAKSRGAFILEIN 212 >UniRef50_B7IF48 NAD-dependent deacetylase n=1 Tax=Thermosipho africanus TCF52B RepID=B7IF48_THEAB Length = 235 Score = 112 bits (279), Expect = 1e-23, Method: Compositional matrix adjust. Identities = 64/187 (34%), Positives = 107/187 (57%), Gaps = 12/187 (6%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 ++ ++VLTGAGIS +SGI FR+ DGL++++ E + + F +P + FY+ + Sbjct: 9 IKNGNIVVLTGAGISTKSGIPDFRSKDGLYQKYG-EKIFDLQFFFENPSV---FYDFVYK 64 Query: 61 QL-QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCS 119 + + + +PN AH+ LAKL+ G ++TQNIDNLH +AG+ NV+ +HG + C+ Sbjct: 65 EFPKMYDAKPNFAHIFLAKLEKN-GYINGIITQNIDNLHYKAGSKNVLELHGNATRFYCT 123 Query: 120 QSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTS 179 + G+ T D + C+ +RP +V+F E ++E Y + + I +G+S Sbjct: 124 KCGKQSKNTFD------GYICECGGLIRPDIVFFSESVRYLEESYTLIDNSSTLIVVGSS 177 Query: 180 GHVYPAA 186 VYPAA Sbjct: 178 LQVYPAA 184 >UniRef50_A6DC77 Silent information regulator protein Sir2 n=1 Tax=Caminibacter mediatlanticus TB-2 RepID=A6DC77_9PROT Length = 243 Score = 111 bits (278), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 78/241 (32%), Positives = 128/241 (53%), Gaps = 25/241 (10%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEH--RVEDVATPEGFDRDPE-----LVQAFYNA 57 ++ TGAGIS ESGI TFR GLW ++ ++ D+ + F ++P+ + + FY+ Sbjct: 16 NLVAFTGAGISVESGIPTFRGPTGLWSKYDPKILDI---DFFIQNPKESWKYIKEIFYDY 72 Query: 58 RRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVR 117 + +I+PN AH LA L+ G ++TQNIDNLH++AG+ NVI HG K+ Sbjct: 73 MQ------DIKPNEAHYFLADLEKK-GILKAVITQNIDNLHQKAGSKNVIEFHGTANKLE 125 Query: 118 CSQSGQVLDWTGDVTPEDKCHCC-QFPAPLRPHVVWFGEMPLGMD----EIYMALSMADI 172 C + + +V E+ C + L+P V+F E P+ + IY + + ADI Sbjct: 126 CLNCKSKFN-SFEVPLENIPPLCPKCNGVLKPDFVFFKE-PIPKEAFEKSIYYSQN-ADI 182 Query: 173 FIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 + IGT+G + PA+ AK +GA +E+N+EPS N + + + + + ++ L Sbjct: 183 MLVIGTTGEIMPASELPLLAKQNGAAIIEINIEPSNYTNSITDIFLKDKATIAAKKLKSL 242 Query: 233 L 233 Sbjct: 243 F 243 >UniRef50_D1A1X3 Silent information regulator protein Sir2 n=13 Tax=Actinomycetales RepID=D1A1X3_THECD Length = 259 Score = 111 bits (278), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 85/251 (33%), Positives = 122/251 (48%), Gaps = 29/251 (11%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLW-EEHRVEDVATPEGFDRDPELVQAFYNARRR 60 E + VLTGAGIS +SGI FR G+W ++ +++ + + DP++ + + ARR Sbjct: 11 EARSITVLTGAGISTDSGIPDFRGPQGVWTKDPSAAALSSLDAYLADPQVRRRVWQARRD 70 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNT--NVIHMHGELLKVRC 118 +PNAAHLAL KL+ A G +VTQNID LH+ AG++ VI +HG + +V C Sbjct: 71 HPAW-HAEPNAAHLALVKLERA-GRLRAIVTQNIDGLHQAAGSSPKTVIEIHGTMREVEC 128 Query: 119 SQSG------QVLDWTGDVTPEDKCHCC---------QFPAPLRPHVVWFGEMPLGMDEI 163 + G QVL + + C C F LRP V + Sbjct: 129 LECGLRTPTQQVLKRLEEGEADPPCLECGGIQKAATISFGQALRPQV---------LQAA 179 Query: 164 YMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQ 223 A D+F+A+GTS V+PAAG EA HGA V +N +P+ P + Sbjct: 180 VRAARSCDLFMAVGTSLTVHPAAGLCLEAVEHGARLVIVNAQPTPYDGIADAVLREPIGE 239 Query: 224 VVPEFVEKLLK 234 +P VE L+ Sbjct: 240 ALPGLVELALR 250 >UniRef50_C6BY08 Silent information regulator protein Sir2 n=1 Tax=Desulfovibrio salexigens DSM 2638 RepID=C6BY08_DESAD Length = 248 Score = 111 bits (277), Expect = 2e-23, Method: Compositional matrix adjust. Identities = 86/245 (35%), Positives = 118/245 (48%), Gaps = 25/245 (10%) Query: 1 MEKPRV-LVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARR 59 ++K R + LTGAG+S SGI FR+ GLW +H E VA+ DP V F Sbjct: 15 IKKARCAIALTGAGMSVASGIPDFRSPGGLWSKHDPEKVASIRALQSDPVTVWKFLLEAD 74 Query: 60 RQLQQPEIQPNAAHLALAKLQDALGDRFL--LVTQNIDNLHERAGNTNVIHMHGELLKVR 117 L+ E PNA H LA+L+ D FL ++TQNID LH+RAG+ NVI HG + Sbjct: 75 SMLKSAE--PNAGHTGLAQLEK---DGFLQGVITQNIDGLHQRAGSVNVIEFHGNCSEFY 129 Query: 118 CSQSGQVLDW----TGDVTPEDKCHCCQFPAPLRPHVVWFGE-MPLGMDEIYMA----LS 168 C + +G P C Q +RP +V+FGE +P E Y A Sbjct: 130 CMECFAPFPAERIESGSELP---VRCPQCSGVIRPDLVFFGEQIP---SEAYKAAFELAD 183 Query: 169 MADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYY-GPASQVVPE 227 +D+ I GTSG V PA+ + G +E+N PS F++ + G V+P Sbjct: 184 QSDLVIVAGTSGGVVPASLIPPRIQEAGGLIIEINKAPSAY-TSFSDVFIQGAVEDVLPA 242 Query: 228 FVEKL 232 V+ L Sbjct: 243 IVQNL 247 >UniRef50_D1UAS5 Silent information regulator protein Sir2 n=1 Tax=Desulfovibrio aespoeensis Aspo-2 RepID=D1UAS5_9DELT Length = 249 Score = 110 bits (276), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 81/239 (33%), Positives = 118/239 (49%), Gaps = 24/239 (10%) Query: 7 LVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPE-----LVQAFYNARRRQ 61 + TGAGIS ESGI FR G+W +H D F R P+ L + F++ R Sbjct: 20 IAFTGAGISVESGIPPFRGPGGVWSKHD-PDKFEKTYFQRHPQEVWPLLKEIFFDTLGRA 78 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 +PN AHLALAKL++A G ++TQNID LH+ AG+ V HG ++ C Sbjct: 79 ------RPNPAHLALAKLEEA-GRLAAIITQNIDGLHQAAGSKTVYEYHGSTRRMECLDC 131 Query: 122 GQVLDWTGDVTPEDK----CHCCQFPAPLRPHVVWFGE-MPLGMDEIYMALS-MADIFIA 175 G D P D+ C C L+P V+F E +P + + L+ +D+ + Sbjct: 132 GAFFDSAS--IPLDRLPPPCPACG--GLLKPDFVFFSEPIPFEVHQAATNLARQSDVCLI 187 Query: 176 IGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYY-GPASQVVPEFVEKLL 233 +GT G V PA HE + G VE+NL ++ F++ + G A +VPE V ++ Sbjct: 188 VGTGGEVMPAGRIPHEVRNAGGKVVEINLYETRYSYGFSDVFLQGRAGVLVPELVGMVM 246 >UniRef50_Q0AY57 Regulatory protein, sir2 family n=1 Tax=Syntrophomonas wolfei subsp. wolfei str. Goettingen RepID=Q0AY57_SYNWW Length = 253 Score = 110 bits (276), Expect = 3e-23, Method: Compositional matrix adjust. Identities = 83/242 (34%), Positives = 121/242 (50%), Gaps = 19/242 (7%) Query: 7 LVLTGAGISAESGIRTFRAADGLWE---EHRVEDVATPEGFDRDPELVQAFYNARRRQLQ 63 +V+TGAGIS E+GI FR +G++ E+RV + + F +P FY R+ Sbjct: 19 VVVTGAGISTEAGIPDFRGPEGIYRKLGENRVMKIINIDFFRNNP---LEFYKFYRQYFI 75 Query: 64 QPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG- 122 P ++P AH LA+++ A G +VTQNIDNLH++AG+ VI +HG + C + Sbjct: 76 FPPVEPGKAHQVLAEMEKA-GIIKAIVTQNIDNLHQKAGSQKVIPIHGNGARFLCQERNC 134 Query: 123 -QVLDWTG-DVTPEDKCHCCQFPAPLRPHVVWFGE----MPLGMDEIYMALSMADIFIAI 176 V D + PE C Q L+P VV FGE P MD I A + + I Sbjct: 135 RSVHDSNYVNTYPEVIPRCSQCGGILKPDVVLFGEHIKNYPDAMDRIL----GARVLVVI 190 Query: 177 GTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYY-GPASQVVPEFVEKLLKG 235 G+S VYP AGFV E + + +N P+ + + K G +++ E EK+ K Sbjct: 191 GSSLTVYPLAGFVKEFSTFTQYLIIINKGPTPLDHAAVVKLQEGNTGELLEEIFEKIKKR 250 Query: 236 LK 237 K Sbjct: 251 RK 252 >UniRef50_C8X5T0 Silent information regulator protein Sir2 n=3 Tax=Desulfovibrionales RepID=C8X5T0_DESRD Length = 254 Score = 110 bits (276), Expect = 4e-23, Method: Compositional matrix adjust. Identities = 77/237 (32%), Positives = 118/237 (49%), Gaps = 16/237 (6%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQP 65 + TGAGIS SGI FR+ GLW + E V + ++P V F R L+ Sbjct: 22 TVAFTGAGISVPSGIPDFRSPGGLWSRYDPEQVCSEWALRKNPVGVWEFL---RDALELF 78 Query: 66 EI-QPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQV 124 + PN AH+ALA+L+ G ++TQNIDNLH+ AG+ VI HG + C G Sbjct: 79 DTATPNQAHIALAELEQQ-GLLSAVITQNIDNLHQEAGSQEVIEYHGNCRRYYCH--GCA 135 Query: 125 LDWTGD-----VTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMA---DIFIAI 176 + D V + C A +RP VV+FGE + + ++ + ++A D+ I + Sbjct: 136 ASYPSDQIAAQVRRKIPVLCASCEAVIRPDVVFFGEA-IPQEALFRSAALAREADVMIVV 194 Query: 177 GTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLL 233 GTSG V PA E G +E N+ P+ + + ++ G A +++P ++LL Sbjct: 195 GTSGTVAPANIIPQEVAARGGTVIECNIGPTAYADVTSIRFDGAAEEILPLLAQQLL 251 >UniRef50_C0QHD0 NpdA n=1 Tax=Desulfobacterium autotrophicum HRM2 RepID=C0QHD0_DESAH Length = 278 Score = 110 bits (274), Expect = 6e-23, Method: Compositional matrix adjust. Identities = 77/202 (38%), Positives = 101/202 (50%), Gaps = 31/202 (15%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLW----EEHRVEDVATPEGFDRDPELVQAFYNARRR 60 R+ VL+GAGISAESGI TFR +G W E+R E++AT F RDP V A+Y RR Sbjct: 16 RLTVLSGAGISAESGIPTFRGPEGYWTIGSREYRPEEMATHAMFSRDPWEVWAWYLYRRT 75 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGN--TNVIHMHGELLKVRC 118 PN H A+ +++ LGDRF LVTQN+D LH AGN + +HG L +RC Sbjct: 76 VCASA--APNHGHRAIVEMEALLGDRFRLVTQNVDGLHLNAGNSPSRTFQIHGNLNFMRC 133 Query: 119 SQSG-----------QVLDWTGDVTPEDK--CHCCQFPAPLRPHVVWFGEMPLGMDEIYM 165 +Q + VTP +K C + RPHV+WF E DE Sbjct: 134 AQGCCNTLFPFPDQVEYKKKNQAVTPVEKELLRCPRCRGLARPHVLWFDEY---YDEALF 190 Query: 166 ALSMA-------DIFIAIGTSG 180 A D+ + +GT+G Sbjct: 191 QAETAFQWAITTDLLVVVGTAG 212 >UniRef50_D2RNB5 Silent information regulator protein Sir2 n=1 Tax=Acidaminococcus fermentans DSM 20731 RepID=D2RNB5_ACIFE Length = 257 Score = 110 bits (274), Expect = 6e-23, Method: Compositional matrix adjust. Identities = 82/246 (33%), Positives = 120/246 (48%), Gaps = 26/246 (10%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVE-DVATPEGFDRDPELV---QAFYNA 57 E ++ GAG+S SGI FR+ DGL+ +H V D PE LV + ++ Sbjct: 19 EADHIVFFGGAGVSTASGIPDFRSKDGLYNQHDVRFDQYRPEYLLSHSCLVNEPKVYFEF 78 Query: 58 RRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVR 117 R+++ +IQPN AH LA L+ G +VTQNID LH++AG+ V +HG L+ Sbjct: 79 HRQKMDTRKIQPNNAHKYLAALEKT-GKLDGIVTQNIDGLHQKAGSRKVYEIHGSALRNY 137 Query: 118 CSQSGQVLDWTGDVTPEDK-----CHCCQFPAPLRPHVVWFGEM--PLGMDEIYMALSMA 170 C G+ + D E K C C +RP + + EM ++ A+S A Sbjct: 138 CMSCGK--RYPSDYIFESKEPIPHCTC---GGVIRPDITLYEEMLPDEAVENAVRAISRA 192 Query: 171 DIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVE 230 D+ I GTS VYPAA F++ HG V LN +P V + + V+ E ++ Sbjct: 193 DLMIIAGTSLTVYPAASFIN--YFHGKRLVILNRDPLSV-------HMKAETLVITENMD 243 Query: 231 KLLKGL 236 K+ K L Sbjct: 244 KVFKAL 249 >UniRef50_C0GT54 Silent information regulator protein Sir2 n=1 Tax=Desulfonatronospira thiodismutans ASO3-1 RepID=C0GT54_9DELT Length = 249 Score = 109 bits (273), Expect = 7e-23, Method: Compositional matrix adjust. Identities = 78/232 (33%), Positives = 113/232 (48%), Gaps = 8/232 (3%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQP 65 +L LTGAGIS SGI FR+ GLW + + VA+ + +P V F + Sbjct: 21 MLALTGAGISVASGIPDFRSPGGLWSRYDPQAVASDWALENNPRQVWEFLLEAVGMIAAA 80 Query: 66 EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVL 125 +PN AH +LA+++D +G ++TQNIDNLH+RAG+ VI HG C + + Sbjct: 81 --KPNPAHESLARMED-MGYLKAVITQNIDNLHQRAGSRKVIEFHGGAGTFYCHKCKKKY 137 Query: 126 DWTG--DVTPED-KCHCCQFPAPLRPHVVWFGEM--PLGMDEIYMALSMADIFIAIGTSG 180 + ++T +D C Q +RP VV+FGE + E + AD+ + GTSG Sbjct: 138 NQQKALELTRKDIPWLCSQCYGVVRPGVVFFGEQIPEQALQETRRLVLAADLVLVAGTSG 197 Query: 181 HVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 V PA K G +E+NL + N + PA +P VE L Sbjct: 198 DVAPAGTLPRWVKEQGGRVIEVNLGRTSFQNISDIRLDEPAETALPRIVEAL 249 >UniRef50_A9AZF2 Silent information regulator protein Sir2 n=1 Tax=Herpetosiphon aurantiacus ATCC 23779 RepID=A9AZF2_HERA2 Length = 171 Score = 107 bits (268), Expect = 2e-22, Method: Compositional matrix adjust. Identities = 67/158 (42%), Positives = 91/158 (57%), Gaps = 9/158 (5%) Query: 66 EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQ-V 124 ++QPNA H+ALA+L+ + ++TQNID LH+RAG+T VI +HG + V CS + Sbjct: 3 DVQPNAGHVALAQLEQHIPS-VTIITQNIDGLHQRAGSTRVIELHGTINTVSCSAAEHGS 61 Query: 125 LDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIY---MALSMADIFIAIGTSGH 181 L W D C C APLRP VVWFGE L + +I +A D+F+AIGTSG Sbjct: 62 LAWP-DSPNLPFCSVCA--APLRPDVVWFGER-LDLAKIQAAELASQTCDVFLAIGTSGV 117 Query: 182 VYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYG 219 V PAA F A+ H A ++LNLE + + + G Sbjct: 118 VAPAATFPMTARAHRARLIDLNLEDTPLSRHARHRLRG 155 >UniRef50_A1ZPG8 NAD-dependent deacetylase n=1 Tax=Microscilla marina ATCC 23134 RepID=A1ZPG8_9SPHI Length = 278 Score = 107 bits (268), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 79/226 (34%), Positives = 115/226 (50%), Gaps = 27/226 (11%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEE----HRVEDVATPEGFDRDPELVQAFYNARRRQ 61 + LTGAGISAESG+ T+R DG+W E ++ E+ AT F +P V F R+ Sbjct: 22 ITFLTGAGISAESGVPTYRGTDGIWVEGSRNYKPEEFATLRFFKENPAEVWKFVLYRKVS 81 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNT--NVIHMHGELLKVRCS 119 + ++QPNA HLALA + L + F L+TQNID LH +AGNT V+ +HG + VRCS Sbjct: 82 FR--DLQPNAGHLALASTEVLLPNNFRLITQNIDRLHIKAGNTQAKVLEIHGNMETVRCS 139 Query: 120 Q--SGQVLDWTGDV--TPED---------KCHCCQFPAPLRPHVVWFGE-----MPLGMD 161 + S V + D+ P D + C + +RP+V+ F E + Sbjct: 140 EECSMDVYPFPLDIGTAPYDAKMITQQWEQLKCPDCGSLMRPNVLMFDEYYNERLYKQES 199 Query: 162 EIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPS 207 I AL+ +F+ +GTSG A G+ V++N+ S Sbjct: 200 AIEAALNTGVLFV-VGTSGATNLPHHIASTATYRGSSLVDINIADS 244 >UniRef50_C3WP91 SIR2 family protein n=9 Tax=Fusobacterium RepID=C3WP91_9FUSO Length = 253 Score = 107 bits (267), Expect = 3e-22, Method: Compositional matrix adjust. Identities = 72/214 (33%), Positives = 111/214 (51%), Gaps = 22/214 (10%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWE-----EHRVEDVATPEGFDRDPELVQAFYNARRR 60 ++ TGAG+S +SG+++FR DGL+ ++R E+V + + F + F Sbjct: 31 LVFFTGAGVSTDSGLKSFRGKDGLYSTLYKGKYRPEEVLSSDFFYSHRNI---FMEYVEN 87 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 +L I+PN HLALA+L+ +G ++TQNID+LH+ AGN NV+ +HG L + C + Sbjct: 88 ELNINGIKPNKGHLALAELE-RIGLLKAVITQNIDDLHQVAGNKNVLELHGSLKRWYCLE 146 Query: 121 SGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGE--MPLGMDEIYMALSMADIFIAIGT 178 G+ D C+ +RP V +GE ++E L AD I GT Sbjct: 147 CGK---------TADNNFSCECGGIVRPDVTLYGENLNQAVVNEAIYQLEQADTLIVAGT 197 Query: 179 SGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNE 212 S VYPAA ++ K G + V +N E +Q +E Sbjct: 198 SLTVYPAAYYLRYFK--GKNLVIINNENTQYDSE 229 >UniRef50_C9STC7 NAD-dependent deacetylase sirtuin-5 n=5 Tax=Sordariomyceta RepID=C9STC7_VERA1 Length = 287 Score = 107 bits (266), Expect = 5e-22, Method: Compositional matrix adjust. Identities = 86/278 (30%), Positives = 122/278 (43%), Gaps = 47/278 (16%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 + PR+L L GAG+SA SG+ TFR A GLW H +ATPE F DP LV FY RR Sbjct: 15 LHTPRILALCGAGLSASSGLPTFRGAGGLWRRHDATRLATPEAFAADPALVWLFYAYRRH 74 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGN--TNVIHMHGELLKVRC 118 P LA FL +TQN+D L +RAG+ + +HG L+ Sbjct: 75 MALAARPNPAHRALAALARAAP---GFLCLTQNVDGLSQRAGHPAAQLRALHGNPLRAAH 131 Query: 119 SQSG-------------QVLDWTGDVTPE------DKCH------------CCQFPAPLR 147 G + + DV P D H C + + LR Sbjct: 132 QGCGYQEEENLADPLVPALAPASADVAPGQTPPLLDAAHPLPSIGRDALPSCPRCSSLLR 191 Query: 148 PHVVWFGEM--PLGMDEI--YMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELN 203 P VVWFGE +D I ++ D+ + +GTS V+PAA +V + GA ++ Sbjct: 192 PGVVWFGEALDDAVLDSIDGWIEAETVDLVLVVGTSARVFPAAAYVELGRARGARVCVVD 251 Query: 204 LEPSQVGNEFAEK----YYGPASQVVPEFVEKLLKGLK 237 LE VG + + + G A+ ++P + L+ L+ Sbjct: 252 LE---VGRDRRDDVDFVFEGDAAVLLPRMLAPLIGPLE 286 >UniRef50_B0EU66 NAD-dependent deacetylase, putative n=2 Tax=Entamoeba RepID=B0EU66_ENTDI Length = 344 Score = 106 bits (265), Expect = 6e-22, Method: Compositional matrix adjust. Identities = 79/242 (32%), Positives = 118/242 (48%), Gaps = 16/242 (6%) Query: 1 MEKPR-VLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARR 59 MEK + V VLTGAGIS ESGI FR+++GLW+ + + F + PEL + Sbjct: 32 MEKSKNVTVLTGAGISVESGIPDFRSSNGLWKRYDPSVYGSYSNFKKHPEL----FWKMT 87 Query: 60 RQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCS 119 ++ + PN H ALA+L+ +G +VTQN+D LH++AG+ NV+ MHG C Sbjct: 88 EEIHKITAYPNHVHEALAELE-KIGVVKTIVTQNVDGLHQQAGSKNVVEMHGSGRACYCI 146 Query: 120 QSGQVLDWTGDV----TPEDKC--HCCQFPAPLRPHVVWFGEM--PLGMDEIYMALSMAD 171 + D+ P +C C + L+ VV FGE + DE+ A + D Sbjct: 147 DCDYISRADNDIWSKPVPPSQCIPRCPKCGGLLKLDVVLFGEKLDRVTYDEVVEASTKTD 206 Query: 172 IFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAE-KYYGPASQVVPEFVE 230 + IGTS V P AK GA +N + + +E+A+ G ++VP Sbjct: 207 FLLVIGTSLQVAPCNIIPFRAKHCGAQVAFINCSKTPM-DEYADFVVRGDLKEIVPRIAN 265 Query: 231 KL 232 K+ Sbjct: 266 KI 267 >UniRef50_C9R9I3 Silent information regulator protein Sir2 n=1 Tax=Ammonifex degensii KC4 RepID=C9R9I3_AMMDK Length = 252 Score = 106 bits (264), Expect = 8e-22, Method: Compositional matrix adjust. Identities = 84/248 (33%), Positives = 120/248 (48%), Gaps = 33/248 (13%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRA-ADGLWEEHRVEDVATPEGFDRDPELVQAFY---- 55 ++ + TGAG+S ESGI FR+ GLW +AT E F DP F+ Sbjct: 14 LKAQKAYAFTGAGVSTESGIPDFRSPGTGLWSNPEALALATGEAFLHDPARFYRFFLPMW 73 Query: 56 -NARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELL 114 N RR QPN AH ALA+L+ +G +VTQNID LH +AG+ V +HG L Sbjct: 74 QNYRR-------AQPNPAHRALAELEK-MGILRGVVTQNIDGLHRKAGSQVVWEVHGNLE 125 Query: 115 KVRCSQSGQVLD-------WTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMAL 167 + C++ + W D P +C C LRP+VV FGE P+ D A+ Sbjct: 126 NLVCTRCRRAAPFSLAEEAWAKDDLPP-RCGCGGI---LRPNVVLFGE-PMTPDFHRAAI 180 Query: 168 SM---ADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQV 224 + D+ + +G+S VYPAA V A+ + +N EP+ + A G A + Sbjct: 181 FLRQGCDLLLVVGSSLTVYPAASLVDYAR----QLIIVNREPTPADDRAAVVLRGQAGII 236 Query: 225 VPEFVEKL 232 +P+ VE + Sbjct: 237 LPKIVEAV 244 >UniRef50_B8FEP4 Silent information regulator protein Sir2 n=1 Tax=Desulfatibacillum alkenivorans AK-01 RepID=B8FEP4_DESAA Length = 252 Score = 106 bits (264), Expect = 8e-22, Method: Compositional matrix adjust. Identities = 86/255 (33%), Positives = 123/255 (48%), Gaps = 43/255 (16%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 E R + TGAGIS ESGI FR+ G+W+++R P FD + +AR R Sbjct: 14 EGGRNIAFTGAGISTESGIPDFRSQGGIWDQYR------PVYFDE----FMSSRDARVRY 63 Query: 62 LQQP--------EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHG 111 Q + +PNA H ALAKL D +G ++TQNID LH+ +G VI +HG Sbjct: 64 WDQKIAMWDGLEKARPNAGHQALAKLYD-MGLLEAIITQNIDGLHQESGIPGDKVIELHG 122 Query: 112 ELLKVRCSQSGQ----------VLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGE-MPLGM 160 +VRC G+ +LD GD PE CHC + L+P + FG+ MP Sbjct: 123 NTRRVRCMTCGETSTVAEAKQRILD--GDPAPE--CHCGGY---LKPDTISFGQAMPQKE 175 Query: 161 DEIYMALSMA-DIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGN---EFAEK 216 E LS + D F+ +G++ V+PAA A+ GA+ +NL + N + Sbjct: 176 VEAAARLSSSCDFFLVVGSTLVVHPAAMMPEYARRAGAYLAIVNLSDTPYDNACQALVRE 235 Query: 217 YYGPASQVVPEFVEK 231 GP Q + + E+ Sbjct: 236 KAGPVLQAIADMAEE 250 >UniRef50_Q89LY4 NAD-dependent deacetylase 1 n=18 Tax=Proteobacteria RepID=NPD1_BRAJA Length = 254 Score = 105 bits (263), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 82/218 (37%), Positives = 111/218 (50%), Gaps = 18/218 (8%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 E ++ TGAGIS E GI FR+ G+W +R P FD +A + RR+ Sbjct: 21 EAKTIVPFTGAGISTECGIPDFRSPGGIWTRNR------PIPFDGFVASQEARDESWRRR 74 Query: 62 LQQPEI----QPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELLK 115 E +P H ALA L A G ++TQNIDNLH+ +G + +VI +HG Sbjct: 75 FAMEETFAAARPGRGHRALASLYRA-GKVPAVITQNIDNLHQASGFAHEHVIELHGNTTY 133 Query: 116 VRCSQSGQV--LDWTGDVTPEDKC-HCCQFPAPLRPHVVWFGEM-PLGMDEIYMALSMA- 170 RC GQ LDW +D +C P++ + FG+M P + ALS A Sbjct: 134 ARCVGCGQTYQLDWVKRRFDQDGAPNCTVCDEPVKTATISFGQMMPEEEMQRATALSRAC 193 Query: 171 DIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQ 208 D+FIAIG+S V+PAAGF AK GA V +N EP++ Sbjct: 194 DLFIAIGSSLVVWPAAGFPMMAKRAGARLVIINREPTE 231 >UniRef50_A8NIK3 Putative uncharacterized protein n=1 Tax=Coprinopsis cinerea okayama7#130 RepID=A8NIK3_COPC7 Length = 313 Score = 105 bits (263), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 84/288 (29%), Positives = 121/288 (42%), Gaps = 68/288 (23%) Query: 5 RVLVLTGAGISAESGIRTFRAA-DGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQ 63 +V +L GAG+SA SGI T+R D +W+ + +AT EGF++DP F++ R+ Sbjct: 19 QVAILAGAGLSAGSGIPTYRGGPDAIWKNMDHDKLATVEGFEKDPVTCWQFHHMMRQLCL 78 Query: 64 QPEIQPNAAHLAL---------AKLQDALGDRF---LLVTQNIDNLHERA---------- 101 + PNAAH AL AK+ L D L +TQN+D+L R Sbjct: 79 --DATPNAAHRALASLVVPSVRAKVLPGLKDPDSPPLFITQNMDSLSPRTLDEFKDKISS 136 Query: 102 -----GNTNVIHMHGELLKVRCSQSGQVLDWTGD-------------------------- 130 ++ MHG + + +C Q V T Sbjct: 137 GEMEKAKERLVEMHGNIFRQKCLQCKHVSTSTDSHLAPGRYPKDANSPATARLEGTNPSA 196 Query: 131 VTPEDKCHCCQFPA------------PLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGT 178 +D C P+ PLRP VVWFGE+P G+ +I LS D+ I +GT Sbjct: 197 TVSKDDLPRCGGPSWNGSNRYGRCGGPLRPSVVWFGEIPEGLGDIARHLSWTDMLIVVGT 256 Query: 179 SGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVP 226 S V+PAAGF+ K G N + S + + G +V+P Sbjct: 257 SCLVHPAAGFLKTVKDRGGKVAIFNYDASPKDDLADFLFLGKCEEVLP 304 >UniRef50_Q5L014 NAD-dependent deacetylase 1 n=8 Tax=Firmicutes RepID=NPD1_GEOKA Length = 242 Score = 105 bits (262), Expect = 1e-21, Method: Compositional matrix adjust. Identities = 78/214 (36%), Positives = 109/214 (50%), Gaps = 19/214 (8%) Query: 6 VLVLTGAGISAESGIRTFRA-ADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQ 64 +VLTGAG+S ESG+ FR+ GLW ++AT + E FY R R LQQ Sbjct: 13 TVVLTGAGMSTESGLPDFRSPRTGLWARFNPSELATIDALYHRRESFVEFYQYRIRTLQQ 72 Query: 65 PEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQ- 123 QP+ H LA + G +VTQN+D H+ AG+ VI +HG L V C + G+ Sbjct: 73 --CQPHDGHRLLADWERR-GIVQTIVTQNVDGFHQEAGSRRVIELHGSLRTVHCQRCGES 129 Query: 124 ---VLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPL---GMDEIYMALSMADIFIAIG 177 + G +T C+ LRP VV FGE PL + E + A AD+F+ +G Sbjct: 130 KPSFVYLHGVLT-------CECGGVLRPSVVLFGE-PLPEKAITEAWEAAQQADLFLVLG 181 Query: 178 TSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGN 211 +S V PA AK +GA V +N EP+++ + Sbjct: 182 SSLQVSPANQLPLVAKRNGAKLVIINWEPTELDD 215 >UniRef50_C4FX59 Putative uncharacterized protein n=1 Tax=Catonella morbi ATCC 51271 RepID=C4FX59_9FIRM Length = 259 Score = 105 bits (261), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 75/212 (35%), Positives = 112/212 (52%), Gaps = 24/212 (11%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEE-----HRVEDVATPEGFDRDPELVQAFYNARRR 60 ++ GAG+S ESGI FR+A G++ + E + + + + P+L FY+ R+ Sbjct: 28 LVFFGGAGVSTESGIPDFRSAQGVYSQDLGRNFSAEQLISHSMYQKYPQL---FYDFYRK 84 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 L P +PNAAH+ LA+L +A G +++QNID LHE AG+ V+ +HG + + C + Sbjct: 85 HLIYPHAKPNAAHIFLAQL-EASGHLDAVISQNIDTLHEAAGSQCVLKLHGTVDRNICQE 143 Query: 121 SGQVLDWTGDVTPED-----KC-HCCQFPAPLRPHVVWFGEMPLGM---DEIYMALSMAD 171 G+V D + D +C HC L+P V + E L M D+ +A+ AD Sbjct: 144 CGRVYDLKSFLDAYDSQGIPRCPHC---GGVLKPDVTLY-EESLNMEVFDQAILAIQQAD 199 Query: 172 IFIAIGTSGHVYPAAGFVHEAKLHGAHTVELN 203 I GTS VYPAAG + K G H V +N Sbjct: 200 TLIVGGTSLVVYPAAGLLQYFK--GKHLVVIN 229 >UniRef50_B5YJW3 NAD-dependent deacetylase n=1 Tax=Thermodesulfovibrio yellowstonii DSM 11347 RepID=NPD_THEYD Length = 256 Score = 104 bits (260), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 74/207 (35%), Positives = 110/207 (53%), Gaps = 17/207 (8%) Query: 7 LVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQ-P 65 + TGAGIS ESGI FR+ +GLW+ R + T + F D + F+ +R +Q+ Sbjct: 23 VAFTGAGISTESGIPDFRSPNGLWQRFR---IVTYQEFIIDRKARNEFWKMKRELIQEII 79 Query: 66 EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGE---LLKVRCSQS- 121 +PN AH ALA+L+ G ++TQNID LH+ AGN +VI +HG + + C + Sbjct: 80 NAKPNNAHNALAELEKR-GLLKYVITQNIDGLHQMAGNKSVIELHGNQRGYICLDCEKVY 138 Query: 122 --GQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMA---DIFIAI 176 +VL + + +C C ++P +V+FGE P+ E+ MA +A DI I Sbjct: 139 PLEEVLKMLKEQELDLRCEVC--GGIIKPTIVFFGE-PMPEKELLMAQQIANKCDIMFVI 195 Query: 177 GTSGHVYPAAGFVHEAKLHGAHTVELN 203 GTS V PAA A +GA + +N Sbjct: 196 GTSLQVEPAASIPRIAYQNGAKLIFIN 222 >UniRef50_C4GC77 Putative uncharacterized protein n=3 Tax=Clostridiales RepID=C4GC77_9FIRM Length = 281 Score = 104 bits (260), Expect = 2e-21, Method: Compositional matrix adjust. Identities = 76/234 (32%), Positives = 112/234 (47%), Gaps = 37/234 (15%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRV---EDVATPEGFDRDPELVQAFYNAR--- 58 +++ GAG+S ESG++ FR+ DGL+ EH E + + F R PE FY + Sbjct: 22 KIVFFGGAGVSTESGLKDFRSQDGLYHEHYKYPPERILSHSFFMRQPEDFYRFYFDKLLV 81 Query: 59 ----------------RRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG 102 R + I+PNAAH LA+L+ A G ++TQNID LH+RAG Sbjct: 82 DGLAVPKSSGRIGTPARGERSSGVIEPNAAHKKLAELETA-GKLSAVITQNIDGLHQRAG 140 Query: 103 NTNVIHMHGELLKVRCSQSGQVLDWTGDVTPEDK----CHCCQFPAPLRPHVVWFGEMPL 158 + V +HG + + C G D + D HC ++P VV + E Sbjct: 141 SRKVFELHGSIHRNHCMSCGHFFDGEYLLAHRDAEKPVPHCPVCGGIIKPDVVLYEE--- 197 Query: 159 GMDEIYM-----ALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPS 207 G+D+ + A+ AD+ I GTS VYPAAGF+ + G H V +N + + Sbjct: 198 GLDQSVINGALEAIGEADLLIIGGTSLTVYPAAGFIRYYR--GNHLVLINRDAT 249 >UniRef50_C6CZ67 Silent information regulator protein Sir2 n=1 Tax=Paenibacillus sp. JDR-2 RepID=C6CZ67_PAESJ Length = 239 Score = 104 bits (260), Expect = 3e-21, Method: Compositional matrix adjust. Identities = 67/211 (31%), Positives = 112/211 (53%), Gaps = 9/211 (4%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEGFDRDPELVQAFYNARR 59 ++ ++ +GAG+S ESG++ FR+AD G+W ++A E D + E FY R Sbjct: 7 LDSSSTIIFSGAGMSTESGLQDFRSADRGMWNNRNPIELADIEAIDSNREEFIRFYQWRI 66 Query: 60 RQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCS 119 ++ QPN H LA ++ G ++TQN++N HE+AG + +HG+L + C Sbjct: 67 HEMNSH--QPNDGHRILADWENR-GLIKGIITQNVENYHEQAGTRQIAKLHGDLGTLHCM 123 Query: 120 QSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMA---LSMADIFIAI 176 + + + + PE K C +RP+VV FGEM L + +A + ++FI + Sbjct: 124 KCNKQYESKMYLVPE-KMTVCSCGGFIRPNVVLFGEM-LRQSALQLANKLMKDVELFIVL 181 Query: 177 GTSGHVYPAAGFVHEAKLHGAHTVELNLEPS 207 G+S V PA + AK +GA+ V +N +P+ Sbjct: 182 GSSLQVSPANQYPKRAKENGANLVIINNDPT 212 >UniRef50_Q8CJM9 NAD-dependent deacetylase 2 n=8 Tax=Actinomycetales RepID=NPD2_STRCO Length = 241 Score = 103 bits (258), Expect = 4e-21, Method: Compositional matrix adjust. Identities = 81/243 (33%), Positives = 117/243 (48%), Gaps = 15/243 (6%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWE-EHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 KP V +L+GAG+S +SGI +R +GLW + E + T E + DPE+ + + RR Sbjct: 4 KPLVAILSGAGVSTDSGIPDYRGPNGLWRRDPEAEKLVTYEYYMGDPEIRRRSWLMRRDS 63 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNT--NVIHMHG---ELLKV 116 +PNAAH A+A L+ G ++TQN+D LH+ AG + V+ +HG + + Sbjct: 64 AAL-HAEPNAAHRAVADLERR-GVPVRVLTQNVDGLHQLAGVSARKVLELHGTARDCVCT 121 Query: 117 RCSQSGQVLDWTGDVTP-EDKCHCCQFPAPLRPHVVWFGEM--PLGMDEIYMALSMADIF 173 C G + D + ED C L+ V FGE P+ + E +F Sbjct: 122 GCGARGPMADVLARIEAGEDDPPCLDCGGVLKTATVMFGERLDPVVLGEAAAISKACQVF 181 Query: 174 IAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLL 233 +A+GTS V PAAG A HGA V +N EP+ E P +P LL Sbjct: 182 VAVGTSLQVEPAAGLARVAVEHGARLVVVNAEPTPYDELADEVIREPIGSALP----ALL 237 Query: 234 KGL 236 +GL Sbjct: 238 RGL 240 >UniRef50_O07595 NAD-dependent deacetylase n=5 Tax=Bacillus RepID=NPD_BACSU Length = 247 Score = 103 bits (257), Expect = 5e-21, Method: Compositional matrix adjust. Identities = 76/226 (33%), Positives = 110/226 (48%), Gaps = 21/226 (9%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEE--HRVEDVATPEGFDRDPELVQAFYNARR 59 E R++VLTGAG+S ESGI FR+A G+W E R+E ++ + F P L + Sbjct: 10 EAQRIVVLTGAGMSTESGIPDFRSAGGIWTEDASRMEAMSL-DYFLSYPRLFWPKFKELF 68 Query: 60 RQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCS 119 + +PN HL LA+L+ G + + TQNID LH++AG+ +V +HG + C Sbjct: 69 QMKMSGSFEPNEGHLLLAELEKQ-GKQVDIFTQNIDGLHKKAGSRHVYELHGSIQTAACP 127 Query: 120 QSG-----------QVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALS 168 G +V + T D C L+ VV FG+ + D +Y L Sbjct: 128 ACGARYDLPHLLEREVPECTAAGNNGDICGTV-----LKTDVVLFGDAVMHFDTLYEKLD 182 Query: 169 MADIFIAIGTSGHVYPAAGFVHEAKL-HGAHTVELNLEPSQVGNEF 213 AD+ + IGTS V PA +A L G V +NLEP+ + F Sbjct: 183 QADLLLVIGTSLEVAPARFVPEDASLIPGMKKVIINLEPTYCDSLF 228 >UniRef50_A9NEY3 Putative uncharacterized protein n=1 Tax=Acholeplasma laidlawii PG-8A RepID=A9NEY3_ACHLI Length = 236 Score = 103 bits (257), Expect = 6e-21, Method: Compositional matrix adjust. Identities = 70/210 (33%), Positives = 106/210 (50%), Gaps = 14/210 (6%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEE----HRVEDVATPEGFDRDPELVQAFYNARRRQ 61 ++ GAG+S ESGI+ FR+ DGL+ + +R ED+ + F + FY RR Sbjct: 16 IVFFGGAGVSTESGIKDFRSKDGLYSQKFKNYRPEDILSRSFFFNH---TKDFYEYFRRH 72 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 I+PN AH+ L K +++G ++TQNID LH+ AG+ NV+ +HG + + Sbjct: 73 FLDTGIKPNKAHMWL-KDAESIGKVKCVITQNIDGLHQMAGSKNVVELHGSAHRYYTVKK 131 Query: 122 GQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMA---LSMADIFIAIGT 178 Q +D + + ++P VV + E PL + + A +S AD I GT Sbjct: 132 KQPIDGLTYILNTEDIPVDSEGDLIKPDVVLYEE-PLNSEVVRKAIEEISKADTLIVAGT 190 Query: 179 SGHVYPAAGFVHEAKLHGAHTVELNLEPSQ 208 S VYPAA F+ K G H + +N E Q Sbjct: 191 SLTVYPAASFIEYFK--GKHLIVINKEYMQ 218 >UniRef50_Q5BVX8 SJCHGC08739 protein (Fragment) n=1 Tax=Schistosoma japonicum RepID=Q5BVX8_SCHJA Length = 179 Score = 103 bits (256), Expect = 6e-21, Method: Compositional matrix adjust. Identities = 53/122 (43%), Positives = 76/122 (62%), Gaps = 5/122 (4%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQP 65 +LVLTG+GISAES + TFR LW + +D+AT + F P LV FY+ RR ++ Sbjct: 55 ILVLTGSGISAESSVPTFRNYGRLWRKFLSQDLATLDAFRSHPGLVWEFYHHRRETIRLR 114 Query: 66 EIQPNAAHLALA---KLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG 122 QPN+ HLALA KL G F ++TQN+D+LH +AG+ N++ +HG + K RC + Sbjct: 115 --QPNSGHLALAQAEKLYVDSGRSFFVITQNVDDLHAKAGSGNILELHGNVYKTRCLECN 172 Query: 123 QV 124 + Sbjct: 173 DI 174 >UniRef50_C3IUP0 SIR2 n=2 Tax=Bacillus thuringiensis RepID=C3IUP0_BACTU Length = 241 Score = 102 bits (255), Expect = 8e-21, Method: Compositional matrix adjust. Identities = 67/189 (35%), Positives = 99/189 (52%), Gaps = 11/189 (5%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQP 65 ++VLTGAGIS +SG+ +R+ GLW+ + E+++ + PE V+ F + R Sbjct: 15 IVVLTGAGISTDSGLPDYRSNGGLWDGKKPEEISHFSAVGK-PEFVKFFAD---RMNDIS 70 Query: 66 EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVL 125 +PN AH LAK ++ G ++TQNID+ H+ AG+ NVI MHG L + C + Sbjct: 71 NCKPNKAHEILAKWEEQ-GKVKSVITQNIDSYHKDAGSKNVIEMHGHLRNLVCDTCSKEY 129 Query: 126 DWTGDVTPEDKCHC---CQFPAPLRPHVVWFGEM--PLGMDEIYMALSMADIFIAIGTSG 180 D T EDK +C + +RP VV FGE PL + + D+ I +GTS Sbjct: 130 D-NSMYTKEDKDNCGLEWECTGVVRPEVVLFGETLPPLAWHQANEQMKKTDLVIVLGTSL 188 Query: 181 HVYPAAGFV 189 V+P V Sbjct: 189 QVFPFNSLV 197 >UniRef50_B9E751 Putative uncharacterized protein n=1 Tax=Macrococcus caseolyticus JCSC5402 RepID=B9E751_MACCJ Length = 243 Score = 102 bits (254), Expect = 1e-20, Method: Compositional matrix adjust. Identities = 64/193 (33%), Positives = 100/193 (51%), Gaps = 12/193 (6%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWE-----EHRVEDVATPEGFDRDPELVQAFYNARR 59 +++ GAG+S ESGI FR+ADG++ EH E++ + + F++ P + ++ Sbjct: 16 KIVFFGGAGVSTESGIPDFRSADGIFMQETSIEHSPEEIISIDFFNKYP---KQYFKFHF 72 Query: 60 RQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCS 119 +L P +PN AH + KL+ G +VTQNID LH+ AGN+ V+ +HG + C+ Sbjct: 73 DKLVYPHAKPNIAHRFITKLEQQ-GKDVTVVTQNIDGLHQSAGNSKVLELHGNVQTNYCT 131 Query: 120 QSGQVLDWTGDVTPEDKC-HCCQFPAPLRPHVVWFGEM--PLGMDEIYMALSMADIFIAI 176 +V +D C +RP +V +GE + E A+ AD+ I Sbjct: 132 HCKKVYQLEDISMDKDGIPRCLHDGHIIRPDIVMYGEALNSSVITEAITAIQNADMMIIA 191 Query: 177 GTSGHVYPAAGFV 189 GTS VYPA+ FV Sbjct: 192 GTSLVVYPASTFV 204 >UniRef50_Q2LSF2 Sir2 family of NAD+-dependent deacetylase n=2 Tax=Syntrophus aciditrophicus SB RepID=Q2LSF2_SYNAS Length = 271 Score = 101 bits (252), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 83/258 (32%), Positives = 126/258 (48%), Gaps = 36/258 (13%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNA---RRRQ 61 RV+V TGAG+S ESGI FR+ GLW+ FD D + F + RR+Q Sbjct: 27 RVVVFTGAGVSTESGIPDFRSPGGLWDR-----------FDPDDFTIGKFLRSAQTRRKQ 75 Query: 62 LQ-------QPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNT--NVIHMHGE 112 + E QPN AHLA+A+L+ +G ++TQNIDNLH++AGN V +HG Sbjct: 76 WRILIAGGALAEAQPNRAHLAVAELE-KIGKLNCVITQNIDNLHQKAGNAPEKVYELHGN 134 Query: 113 LLKVRCSQSG------QVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGE-MPLGM--DEI 163 + ++C G ++ T + C + ++P V++FGE +P D Sbjct: 135 MRWLKCLSCGDRVSVPEMFRETALQEMDGFPFCAKCQGLMKPDVIFFGEALPEKTLRDAT 194 Query: 164 YMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQ 223 + A + D+ + IG+S VYPAA AK GA V +N + + +E G A + Sbjct: 195 WQARN-CDLLLVIGSSLVVYPAAYMPMYAKDAGARLVIINRDETPYDSEADVLLQGSAGE 253 Query: 224 VVPEFVE--KLLKGLKAG 239 ++ ++ K G K G Sbjct: 254 IMSRILDAVKHRTGFKPG 271 >UniRef50_D0WS10 NAD-dependent deacetylase n=2 Tax=Actinomyces RepID=D0WS10_9ACTO Length = 245 Score = 101 bits (252), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 76/219 (34%), Positives = 115/219 (52%), Gaps = 25/219 (11%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHR---VEDVATPEGFDRDPELVQAFYNAR 58 + R++ GAG+S ESGI FR A+G + + R +E V + + F+ P QA++ Sbjct: 14 QSNRIVFFGGAGVSTESGIPDFRGAEGFFHQDREIPIERVLSIDFFETHP---QAYWEWF 70 Query: 59 RRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHG---ELLK 115 ++ + + PNAAH LA+L+ G +VTQNID LH+ AG+ + +HG LL Sbjct: 71 AQENAREGVAPNAAHRFLAELEKR-GSLSAVVTQNIDGLHQSAGSERIFELHGNWSRLLC 129 Query: 116 VRCSQSGQVLDW----TGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLG---MDEIYMALS 168 + C + + D+ TG V C C +RP +V++GEM LG ++ A++ Sbjct: 130 MGCGRRFSIADFDEARTGAVPRCPSCACV-----VRPDIVFYGEM-LGSGVLEGAVRAIA 183 Query: 169 MADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPS 207 AD+ I GTS VYPAAG V G V +N P+ Sbjct: 184 DADMLIVAGTSLVVYPAAGLVD--YYDGDRLVLMNATPT 220 >UniRef50_Q97MB4 NAD-dependent deacetylase n=71 Tax=cellular organisms RepID=NPD_CLOAB Length = 245 Score = 101 bits (252), Expect = 2e-20, Method: Compositional matrix adjust. Identities = 73/229 (31%), Positives = 111/229 (48%), Gaps = 34/229 (14%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELV---------- 51 E ++ GAG+S ES I FR+ +GL++ T F PE++ Sbjct: 16 ESSSIVFFGGAGVSTESNIPDFRSENGLYK--------TKNNFSYPPEVMLSHTFFKNHT 67 Query: 52 QAFYNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHG 111 + F+ R ++ + +PNAAH +LAK+++ G +VTQNID LH+ AG+ NV +HG Sbjct: 68 EDFFEFYREKMIFKDAKPNAAHYSLAKIEEQ-GKLKAIVTQNIDGLHQLAGSKNVYELHG 126 Query: 112 ELLKVRCSQSGQVLDWTGDVTPED---KCHCCQFPAPLRPHVVWFGEMPLGMDEIYM--- 165 + + C G+ D + E KC C ++P VV + E G+D+ + Sbjct: 127 SIHRNYCMDCGKSFDLEYVIKSETTIPKCDKC--GGIVKPDVVLYEE---GLDDSIIQNS 181 Query: 166 --ALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNE 212 A+S AD I GTS VYPAAG + K G + +N + NE Sbjct: 182 VKAISEADTLIVGGTSLVVYPAAGLIRYFK--GNKLILINKSATAYDNE 228 >UniRef50_Q899G3 NAD-dependent deacetylase n=52 Tax=Bacteria RepID=NPD_CLOTE Length = 247 Score = 101 bits (251), Expect = 3e-20, Method: Compositional matrix adjust. Identities = 69/207 (33%), Positives = 103/207 (49%), Gaps = 32/207 (15%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELV----------QAF 54 ++ GAG+S ES I FR+ +GL++ T F PE++ + F Sbjct: 16 NIVFFGGAGVSTESNIPDFRSEEGLYK--------TKSNFSYSPEVMLSHSFFKEHTEDF 67 Query: 55 YNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELL 114 ++ + ++ +PN AH ALAKL+ +G ++TQNID LH+ AG+ NVI +HG + Sbjct: 68 FDFYKEKMIYKYAKPNLAHHALAKLE-KVGKLKAIITQNIDGLHQLAGSKNVIELHGGVG 126 Query: 115 KVRCSQSGQVLDW-----TGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSM 169 + C + D +V P KC C ++P VV + E PL MD I A+ Sbjct: 127 RNYCMDCNKFFDLNYILNNKEVVP--KCDVCG--GIVKPDVVLY-EEPLNMDNINNAVRY 181 Query: 170 ---ADIFIAIGTSGHVYPAAGFVHEAK 193 +D+ I GTS VYPAA +H K Sbjct: 182 VENSDVLIVGGTSLVVYPAANLIHYYK 208 >UniRef50_A7HL19 Silent information regulator protein Sir2 n=1 Tax=Fervidobacterium nodosum Rt17-B1 RepID=A7HL19_FERNB Length = 244 Score = 100 bits (248), Expect = 5e-20, Method: Compositional matrix adjust. Identities = 70/202 (34%), Positives = 111/202 (54%), Gaps = 11/202 (5%) Query: 8 VLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQPEI 67 VLTGAG+S SGI FR+ +G++ + +++ + F ++P+ F A++ ++ ++ Sbjct: 19 VLTGAGVSVPSGIPDFRSKNGVYSKWG-QEIFDIDLFHQNPDRFYEF--AKQELIKMLDV 75 Query: 68 QPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVLDW 127 +PN H LA L+ L ++TQNIDNLH++AG+ V +HG + C + G+ D Sbjct: 76 EPNEIHYLLAYLE-KLNIVKGVITQNIDNLHKKAGSQKVAEIHGNVRTWSCLKCGKRYDL 134 Query: 128 TGDVTPE---DKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMA---DIFIAIGTSGH 181 E D+ C+ +P +V+FGEM L ++E A + A D+FIA+GTS Sbjct: 135 FNSQHKEFLIDRNFRCECGGVTKPDIVFFGEM-LPLNEYSKAENWAKESDVFIAMGTSLV 193 Query: 182 VYPAAGFVHEAKLHGAHTVELN 203 VYPAA AK GA +N Sbjct: 194 VYPAAQLPIYAKHSGAKLCIIN 215 >UniRef50_Q0CI01 Putative uncharacterized protein n=2 Tax=Leotiomyceta RepID=Q0CI01_ASPTN Length = 320 Score = 99.8 bits (247), Expect = 7e-20, Method: Compositional matrix adjust. Identities = 56/118 (47%), Positives = 75/118 (63%), Gaps = 5/118 (4%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQ 64 RV+ L GAGISA SG+ TFR A GLW + D+ATPE F+ +P+LV FY+ RR + Sbjct: 23 RVIALLGAGISASSGLPTFRGAGGLWRTYEATDLATPEAFEANPDLVWQFYSYRRHMALK 82 Query: 65 PEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGN-TNVIH-MHGELLKVRCSQ 120 QPN AH ALA+L D F+ +TQN+D L +RA + + IH +HG L V+C+ Sbjct: 83 --AQPNRAHHALAELARRNKD-FITLTQNVDGLSQRAQHPSEQIHLLHGSLFTVKCTS 137 >UniRef50_Q8REC3 NAD-dependent deacetylase n=8 Tax=Fusobacterium RepID=NPD_FUSNN Length = 252 Score = 99.8 bits (247), Expect = 7e-20, Method: Compositional matrix adjust. Identities = 71/238 (29%), Positives = 119/238 (50%), Gaps = 34/238 (14%) Query: 11 GAGISAESGIRTFRAADGLW-----EEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQP 65 GAG S +SG++ FR DGL+ +++R E+V + + F ++ F ++L Sbjct: 27 GAGTSTDSGVKDFRGKDGLYKTLYKDKYRPEEVLSSDFFYSHRDI---FMKYVEKELNIK 83 Query: 66 EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVL 125 ++PN H+AL +L+ +G ++TQNID+LH+ +GN NV+ +HG L + C G+ Sbjct: 84 GLKPNKGHMALVELE-KIGILKAVITQNIDDLHQVSGNKNVLELHGSLKRWYCLSCGK-- 140 Query: 126 DWTGDVTPEDKCHCCQFPAPLRPHVVWFGE--MPLGMDEIYMALSMADIFIAIGTSGHVY 183 D+ C+ +RP V +GE ++E L AD I GTS VY Sbjct: 141 -------TADRNFSCECGGVVRPDVTLYGENLNQSVVNEAIYQLEQADTLIVAGTSLTVY 193 Query: 184 PAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPE----FVEKLLKGLK 237 PAA ++ G + + +N +Q Y G AS V+ + +++++K LK Sbjct: 194 PAAYYLRY--FRGKNLIIINDMDTQ--------YDGEASLVIKDNFSYVMDRVVKELK 241 >UniRef50_Q81BT4 NAD-dependent deacetylase n=75 Tax=Bacillus RepID=NPD_BACCR Length = 245 Score = 99.4 bits (246), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 79/232 (34%), Positives = 114/232 (49%), Gaps = 13/232 (5%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQ 64 ++ VLTGAG S ESGI FR+A+GL+ + VE + ++R P+ Y + Sbjct: 19 KITVLTGAGASTESGIPDFRSANGLYADANVEMYLSRGYYNRSPKEFWKHYKEIFQINTF 78 Query: 65 PEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRC--SQSG 122 + +PN H LA+L++ G ++TQNID LH+ G+ +VI +HG L C +SG Sbjct: 79 HQYKPNRGHRFLAELEEQ-GKDITILTQNIDGLHQLGGSKHVIDLHGTLQTAHCPKCKSG 137 Query: 123 QVLDWTGD-VTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGH 181 L + D P +C C F L P VV +G+ L D+ I +GTS Sbjct: 138 YDLQYMIDHEVP--RCEKCNF--ILNPDVVLYGDTLPQYQNAIKRLYETDVLIVMGTSLK 193 Query: 182 VYPAAGFVHEAKLH-GAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 V P A F AK GA T+ +N E + G E+ + + EFVE L Sbjct: 194 VQPVASFPQIAKREVGATTILVNEELT--GQEYNFDFV--FQNKIGEFVEGL 241 >UniRef50_C1ZIT2 NAD-dependent protein deacetylase, SIR2 family n=1 Tax=Planctomyces limnophilus DSM 3776 RepID=C1ZIT2_PLALI Length = 271 Score = 99.4 bits (246), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 80/233 (34%), Positives = 113/233 (48%), Gaps = 37/233 (15%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGF------DRDPELVQAFYNAR 58 R++V TGAGIS+ESGI TFR DG W+ E AT +G DR + Q +N Sbjct: 18 RIVVFTGAGISSESGIPTFRDNDGFWQRFPPERFATWKGLLQTALTDRH-SVAQFIFNVI 76 Query: 59 RRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRC 118 + +PNA H A+A +Q + +VTQNID LH+ AG+T+V+ +HG L++V Sbjct: 77 EPIAKS---EPNAGHAAVASIQQRVSTT--VVTQNIDGLHQSAGSTSVLEIHGSLMEVVD 131 Query: 119 SQSGQV---LDWTGDVTPEDKCH--------CCQFPAPLRPH--VVWFG----EMPLGMD 161 SG++ LD D H +F LR H WFG + L D Sbjct: 132 VTSGEIVQKLDRNDLARIADIVHMYANHQVSVIRFLWNLRKHYPFDWFGRHRPNLVLFGD 191 Query: 162 EI--------YMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEP 206 ++ A D+ ++IGTSG VYPAA A GA + ++ +P Sbjct: 192 DLPEPAWAKACQASRECDVLLSIGTSGAVYPAALLPGTAAASGATVISIDPQP 244 >UniRef50_D1B8J6 Silent information regulator protein Sir2 n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B8J6_THEAS Length = 246 Score = 99.4 bits (246), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 66/190 (34%), Positives = 99/190 (52%), Gaps = 12/190 (6%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQ--AFYNARRRQL 62 R++VLTGAGIS SGI FR +G++ + E FD D +V FY RR L Sbjct: 15 RIVVLTGAGISTASGIPDFRGPNGIYRQLGAE---AERIFDIDHFMVNPSTFYGFHRRFL 71 Query: 63 QQPE-IQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 + E ++P+ AH +AKL++ ++TQN+D LH+RAG+ NVI +HG + + C Sbjct: 72 EMVEAVRPSFAHRFIAKLEET--KDLAVITQNVDGLHQRAGSRNVIEIHGGIGENSCLTC 129 Query: 122 GQVLDWTGDVTP---EDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGT 178 G+ GD+ E + C ++PHVV+FGE +D + + +G+ Sbjct: 130 GRTYSL-GDLKAMMEEREVPLCSCGGLIKPHVVFFGEGVRDLDRCMELSRDCQVMLVVGS 188 Query: 179 SGHVYPAAGF 188 S V PAA Sbjct: 189 SLTVTPAASL 198 >UniRef50_Q9WYW0 NAD-dependent deacetylase n=5 Tax=Thermotogaceae RepID=NPD_THEMA Length = 246 Score = 99.0 bits (245), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 74/209 (35%), Positives = 108/209 (51%), Gaps = 11/209 (5%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 E + LTGAGIS SGI FR +G+++++ ++V + F PE F A+ Sbjct: 12 ESRLTVTLTGAGISTPSGIPDFRGPNGIYKKYS-QNVFDIDFFYSHPEEFYRF--AKEGI 68 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHG---ELLKVRC 118 + +PN AH+ LAKL++ G ++TQNID LH+RAG+ VI +HG E VRC Sbjct: 69 FPMLQAKPNLAHVLLAKLEEK-GLIEAVITQNIDRLHQRAGSKKVIELHGNVEEYYCVRC 127 Query: 119 SQSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMAL---SMADIFIA 175 + V D + D C + +RP++V+FGE L D + A+ S A + I Sbjct: 128 EKKYTVEDVIKKLESSDVPLCDDCNSLIRPNIVFFGE-NLPQDALREAIGLSSRASLMIV 186 Query: 176 IGTSGHVYPAAGFVHEAKLHGAHTVELNL 204 +G+S VYPAA G V +NL Sbjct: 187 LGSSLVVYPAAELPLITVRSGGKLVIVNL 215 >UniRef50_C7MBX0 NAD-dependent protein deacetylase, SIR2 family n=1 Tax=Brachybacterium faecium DSM 4810 RepID=C7MBX0_BRAFD Length = 259 Score = 99.0 bits (245), Expect = 1e-19, Method: Compositional matrix adjust. Identities = 78/241 (32%), Positives = 116/241 (48%), Gaps = 25/241 (10%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGF--DRDPELVQAFYNARRRQLQ 63 ++ LTG+GISA +G+ TFR DGLW + A G D P+L + + R + Sbjct: 16 IIFLTGSGISARTGLGTFRGPDGLWALEPETEQAMHAGLLPDSLPQLWRVWGRMARIARE 75 Query: 64 QPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQ 123 P H A+A+L + +TQNID LH+ AG+ V +HG L+ C G+ Sbjct: 76 H---GPTPGHRAIARLGAPV------ITQNIDGLHQAAGSEVVTELHGSALRAACL--GE 124 Query: 124 VLDWTGDVTPED---------KCHCCQFPAPLRPHVVWFGEM--PLGMDEIYMALSMADI 172 W+ + P D C + AP RP VV F E P +D AD+ Sbjct: 125 ACLWSALLEPGDGSRPEDHGVPASCPRCGAPTRPDVVLFDEQLPPQALDLAMRLAQRADL 184 Query: 173 FIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYG-PASQVVPEFVEK 231 F+A+GTSG V+PAA A HGA TV ++++P E + A +V+P++ + Sbjct: 185 FVAVGTSGVVFPAAQLAPLAAAHGATTVLVDIDPPVGSRELFDHVLAEDAHEVLPDWERR 244 Query: 232 L 232 + Sbjct: 245 I 245 >UniRef50_Q6WIA8 Sir2/CobB protein n=1 Tax=Vibrio phage KVP40 RepID=Q6WIA8_BPKV4 Length = 246 Score = 97.4 bits (241), Expect = 4e-19, Method: Compositional matrix adjust. Identities = 54/126 (42%), Positives = 74/126 (58%), Gaps = 9/126 (7%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQ 64 R+ + +GAG+ AESGI TFR A+GLWE H + V F + EL FYN RR QL Sbjct: 2 RIFIFSGAGLDAESGISTFRDANGLWENHDIMQVCNINTFLNNYELTHKFYNQRRVQL-- 59 Query: 65 PEIQPNAAHLALAKLQDALG-DRFLLVTQNIDNLHERAGNTNVIHMHGELLKV---RCSQ 120 ++ PNAAH +A+L + D + T N+ +L ERAG +V H+HGEL K+ S+ Sbjct: 60 ADVHPNAAHYKIAELCEKYDVDNY---TANVSDLLERAGCKDVKHIHGELTKIVQDYTSK 116 Query: 121 SGQVLD 126 V+D Sbjct: 117 DSTVID 122 >UniRef50_B5Y820 Putative NAD-dependent deacetylase 2 n=1 Tax=Coprothermobacter proteolyticus DSM 5265 RepID=B5Y820_COPPD Length = 245 Score = 96.7 bits (239), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 64/183 (34%), Positives = 93/183 (50%), Gaps = 6/183 (3%) Query: 7 LVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQPE 66 +VLTGAGIS ESGI +R GLW ++ + F+ DP+ F +Q Sbjct: 19 VVLTGAGISTESGIPDYRGPQGLWRKYDPIKYVSRSTFETDPKTFWEF--NLPMWMQYKA 76 Query: 67 IQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVLD 126 +PN AH +A+L+ LG ++TQNID LH+RAG+ NV +HG L V C + + Sbjct: 77 AKPNKAHFLVAELE-RLGFIKAVITQNIDGLHKRAGSKNVYEVHGNLETVTCLRCHKEYP 135 Query: 127 WTGDVTPEDKCHC--CQFPAPLRPHVVWFGE-MPLGMDEIYMALSMADIFIAIGTSGHVY 183 + C+ C LRP+VV F + MP + + +D+ I +G+S VY Sbjct: 136 LEEAWKQFNDCNIPQCSCGGLLRPNVVLFEDPMPDTFFQAVREVESSDLMIVMGSSLEVY 195 Query: 184 PAA 186 P A Sbjct: 196 PVA 198 >UniRef50_C4R311 NAD(+)-dependent histone deacetylase n=3 Tax=Saccharomycetales RepID=C4R311_PICPG Length = 325 Score = 96.3 bits (238), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 49/119 (41%), Positives = 74/119 (62%), Gaps = 7/119 (5%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQP 65 +L L GAG+SA SG+ TFR + GLW+ + D+ATP+ F+ DP LV FY+ RR + Q Sbjct: 21 ILALCGAGLSASSGLPTFRGSGGLWKNYSSMDLATPDAFNVDPGLVWQFYSYRRYKAIQ- 79 Query: 66 EIQPNAAHLALAKLQD---ALGDRFLLVTQNIDNLHERAGNT--NVIHMHGELLKVRCS 119 +PN H AL++L + G +FL +TQN+D L RA + ++ +HG L ++C+ Sbjct: 80 -AKPNNGHYALSQLSKVAASKGKKFLTLTQNVDGLSRRAHHDPEQLLELHGSLFTLKCT 137 Score = 57.8 bits (138), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 32/93 (34%), Positives = 53/93 (56%), Gaps = 6/93 (6%) Query: 146 LRPHVVWFGE-MPLGM----DEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTV 200 LRP VVWFGE +P + D+ M+ + D+ + IGTS V+PAAG+V+ KL G Sbjct: 222 LRPGVVWFGESLPFKVLDQADQFIMSQKV-DLILVIGTSQSVWPAAGYVNRVKLQGGKVA 280 Query: 201 ELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLL 233 N + + K+ G A++++P+ ++ L+ Sbjct: 281 IFNTDEEDLEGCDGWKFLGDAAELLPQALKPLI 313 >UniRef50_C6P8W9 Silent information regulator protein Sir2 n=2 Tax=Clostridia RepID=C6P8W9_CLOTS Length = 251 Score = 96.3 bits (238), Expect = 7e-19, Method: Compositional matrix adjust. Identities = 65/190 (34%), Positives = 97/190 (51%), Gaps = 17/190 (8%) Query: 5 RVLVLTGAGISAESGIRTFRA-ADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQ 63 + +VLTGAGIS ESGI FR+ GLWE+ + + DP ++ + N + L Sbjct: 20 KTIVLTGAGISTESGIPDFRSPGTGLWEKMDPMEALSTRVLYNDP--IKFYNNGFKILLS 77 Query: 64 QPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQ 123 + +PN AH LA+L+ G ++TQNIDNLH++AG+ V +HG+ C G+ Sbjct: 78 MKDAKPNKAHYILAQLEQE-GLISGVITQNIDNLHQKAGSHKVFEVHGQTRTGSCINCGE 136 Query: 124 VLDW--------TGDVTPEDKCHCCQFPAPLRPHVVWFGE-MPLGMDEIYMALSMADIFI 174 V+ ++ P KC C LRP VV FG+ MP + + +D+ + Sbjct: 137 VVSIDLLNSKVEKNEIPP--KCDKCN--GILRPDVVMFGDPMPEDFERAWREAESSDLMV 192 Query: 175 AIGTSGHVYP 184 IG+S V P Sbjct: 193 VIGSSLTVSP 202 >UniRef50_A6TNA0 Silent information regulator protein Sir2 n=2 Tax=Clostridiales RepID=A6TNA0_ALKMQ Length = 249 Score = 96.3 bits (238), Expect = 8e-19, Method: Compositional matrix adjust. Identities = 74/230 (32%), Positives = 98/230 (42%), Gaps = 10/230 (4%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQP 65 ++LTGAG+ ES I FR+ G W VA + F + L FY+ R R L Sbjct: 27 TVILTGAGMDTESNIPDFRSEKGWWRSIDPRTVANIDTFYENYSLFHEFYDMRLRLLVG- 85 Query: 66 EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVL 125 IQP+ H L+ L+ G + TQN+ LH AG+ NV +HG + K+RC+ Sbjct: 86 -IQPHKGHYILSDLEKK-GMIRSIATQNVAGLHVMAGSQNVYELHGNIRKIRCNNCNHEA 143 Query: 126 DWTGDVTPEDKCHCCQFPAPLRPHVVWFGEM--PLGMDEIYMALSMADIFIAIGTSGHVY 183 + E C C LRP V+ FGE P D + D+ I IGTS VY Sbjct: 144 SLERFLAVE-TCGSCG-DKGLRPSVILFGETLPPKAWDSALRDIQKCDLLIVIGTSLEVY 201 Query: 184 PAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLL 233 P H L V +N E F G A +V+ LL Sbjct: 202 PVN---HLPMLTKGKKVFINNEERSTDYAFDLTIIGKAKEVLEALNHYLL 248 >UniRef50_B0S0T6 Transcriptional regulator Sir2 family n=4 Tax=Clostridiales Family XI. Incertae Sedis RepID=B0S0T6_FINM2 Length = 246 Score = 96.3 bits (238), Expect = 9e-19, Method: Compositional matrix adjust. Identities = 69/220 (31%), Positives = 110/220 (50%), Gaps = 20/220 (9%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVA-----TPEGFDRDPELVQAFYN 56 + +++ GAG+S SGI FR+A GL+ + D + + E F P+L Q + Sbjct: 13 QSDKIVFFGGAGVSTASGIPDFRSATGLYNKKNDSDFSPEYMLSHEFFVTHPDLFQDYV- 71 Query: 57 ARRRQLQQPEIQPNAAHLALAKLQDALGDRFL-LVTQNIDNLHERAGNTNVIHMHGELLK 115 L ++PN AHL+L KL+ A ++ L ++TQNID+L AG N+ +HG L Sbjct: 72 --LENLIIDGVKPNNAHLSLRKLEKA--NKLLGVITQNIDSLDTMAGTKNIAEIHGNLRD 127 Query: 116 VRCSQSGQVLDWTGDVTPEDK-CHCCQFPAPLRPHVVWFGEMPLGMDEIYMA---LSMAD 171 C G D D +++ C C + +RP V +GE+P E A ++ AD Sbjct: 128 YYCVNCGAKYDL--DYYKQNRPCKCEKCGGVVRPDVTLYGEVP-PQSEFAKAINWINKAD 184 Query: 172 IFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGN 211 I G+S VYPA+G ++ G + + +NL+ + N Sbjct: 185 TMIVAGSSLVVYPASGLIN--YFRGDNLILINLDRTSYDN 222 >UniRef50_C0S043 NAD-dependent deacetylase n=5 Tax=Onygenales RepID=C0S043_PARBP Length = 354 Score = 96.3 bits (238), Expect = 9e-19, Method: Compositional matrix adjust. Identities = 53/117 (45%), Positives = 69/117 (58%), Gaps = 5/117 (4%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQP 65 V+ L GAG+SA SG+ TFR A GLW H V +ATPE F P LV FY+ RR + Sbjct: 28 VMALLGAGLSAASGLPTFRGAGGLWRSHYVTSLATPEAFQSKPALVWQFYSYRRHMALK- 86 Query: 66 EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGN-TNVIH-MHGELLKVRCSQ 120 QPN AH ALA L F+ ++QN+D L RA + + +H +HG L +V+CS Sbjct: 87 -AQPNKAHFALAALAKR-NPNFITLSQNVDGLSPRANHPASQLHLLHGSLFQVKCSS 141 Score = 52.0 bits (123), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 37/107 (34%), Positives = 54/107 (50%), Gaps = 16/107 (14%) Query: 136 KCHCCQFPAPLRPHVVWFGE-MPL----GMDEIYMALSMADIFIAIGTSGHVYPAAGFVH 190 KC C+ LRP VVWFGE +P +D+ D+ + IGTS V+PAAG+V Sbjct: 246 KCPKCKNQL-LRPGVVWFGESLPRQTINAVDDWIDHADKIDLILVIGTSAQVFPAAGYVE 304 Query: 191 EAKLHGAHTVELNLEPSQ-------VGNEFAEKYYGPASQVVPEFVE 230 A+ GA +N++ + G+ F + G AS +VPE + Sbjct: 305 MAREKGARVAVINMDTNDEPPGGMLPGDWF---FQGDASVIVPELLR 348 >UniRef50_B3L8U3 Transcriptional regulatory protein sir2 homologue, putative n=6 Tax=Plasmodium RepID=B3L8U3_PLAKH Length = 301 Score = 95.5 bits (236), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 65/223 (29%), Positives = 107/223 (47%), Gaps = 13/223 (5%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADG-LWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 E V+ LTG+G SAES I +FR + +W ++ + T GF + PE + + R Sbjct: 27 ECTYVVALTGSGTSAESNIPSFRGDNSSIWSKYDPKIYGTIWGFWKSPEKI---WEVIRD 83 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 EI+ N H AL+ L+ +LG ++TQNID LHE +GN+ VI +HG + + RC Sbjct: 84 ISSDYEIELNPGHTALSTLE-SLGYLKAVITQNIDGLHEESGNSKVIPLHGSVFEARCCT 142 Query: 121 SGQVLDWTGDVTPEDKCHCCQFP------APLRPHVVWFGE-MPLG-MDEIYMALSMADI 172 + + + + Q P +P+VV FGE +P + + + D+ Sbjct: 143 CRETIQLNKIMLQKTSHFMHQLPPECPCGGIFKPNVVLFGEVIPKSLLKQAQKEIENCDL 202 Query: 173 FIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAE 215 + +GTS V A + A VE+N+ + + N ++ Sbjct: 203 LLVVGTSSSVSTATNLCYYAHRKKKKIVEVNISKTYITNRLSD 245 >UniRef50_Q8CNF4 NAD-dependent deacetylase n=64 Tax=Staphylococcus RepID=NPD_STAES Length = 246 Score = 95.5 bits (236), Expect = 1e-18, Method: Compositional matrix adjust. Identities = 75/234 (32%), Positives = 120/234 (51%), Gaps = 18/234 (7%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPE---GFDRDPELVQAFYNARRRQ 61 +++ TGAG+S SGI FR+ GL++E +D +PE D + ++F N + Sbjct: 18 QIVFFTGAGVSVASGIPDFRSMGGLYDEIS-KDGQSPEYLLSIDHLHDNKESFINFYHER 76 Query: 62 LQQPEIQPNAAHLALAKL---QDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRC 118 L + +PN H +A+L Q +LG ++TQNID LHE AG+ N+ +HG L + C Sbjct: 77 LLIADKKPNIVHQWIAQLENQQKSLG----VITQNIDGLHEDAGSHNIDELHGTLNRFYC 132 Query: 119 SQSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSM---ADIFIA 175 + + +T K +C + +RP +V +GEM L ++ AL AD I Sbjct: 133 INCYEEYSKSYVMTHHLK-YCEKCGNVIRPDIVLYGEM-LNQKTVFKALDKIQHADTLIV 190 Query: 176 IGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFV 229 +G+S V PAAGFV E K G + V +N + + + + + + V+ E V Sbjct: 191 LGSSLVVQPAAGFVSEFK--GDNLVIINRDATPYDHTASLVIHDDMTSVIEEIV 242 >UniRef50_Q47EY8 Silent information regulator protein Sir2 n=7 Tax=Bacteria RepID=Q47EY8_DECAR Length = 267 Score = 95.5 bits (236), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 86/246 (34%), Positives = 117/246 (47%), Gaps = 34/246 (13%) Query: 7 LVLTGAGISAESGIRTFRAADGLWEEH------RVEDVATPEGFDRDPE-----LVQAFY 55 L +TGAGIS +SG+ T+R GL++ R+ED + E F P+ L+Q Sbjct: 29 LFITGAGISVDSGLPTYRGVGGLYDSETTEEGLRIEDALSGEVFSMRPDITWKYLIQIEE 88 Query: 56 NARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHG---E 112 N R Q PNAAH A+A L+ L DR ++ TQN+D LH AG+ ++ +HG E Sbjct: 89 NCRGAQ-------PNAAHRAIACLERHL-DRVMVFTQNVDGLHRAAGSHEIVEIHGNLQE 140 Query: 113 LLKVRCSQSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSM--- 169 L+ CS D + P C C A LRP VV FGE L DE+ + Sbjct: 141 LMCTACSHEEAATDMSEREVPP-LCPACG--AVLRPKVVLFGEA-LPEDELDRFIEAFQE 196 Query: 170 -ADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGP--ASQVVP 226 DI +IGTS V A G TVE+N P++ YY P A++ + Sbjct: 197 GFDIVFSIGTSSIFPYIVQPVVLAAASGIPTVEIN--PARTKLSDTVDYYLPLGAAEAMS 254 Query: 227 EFVEKL 232 VE+L Sbjct: 255 GIVERL 260 >UniRef50_B0EBU9 NAD-dependent deacetylase, putative n=3 Tax=Entamoeba RepID=B0EBU9_ENTDI Length = 362 Score = 95.1 bits (235), Expect = 2e-18, Method: Compositional matrix adjust. Identities = 68/236 (28%), Positives = 117/236 (49%), Gaps = 10/236 (4%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQP 65 V+VLTGAGIS +GI FR+ +G+W+ + + + E F + PE+ + R+ + Sbjct: 30 VVVLTGAGISVSAGIPDFRSRNGMWKRYEPKIYGSYENFIKRPEMFWKMCSELRKYTEGK 89 Query: 66 EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG--- 122 +P AH AL KL++ ++TQN+DNLH+ AG+ V +HG +C + G Sbjct: 90 --KPTKAHFALRKLEEIGKIE-EIITQNVDNLHQLAGSRKVNELHGTGKICQCIKCGYRG 146 Query: 123 --QVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEI--YMALSMADIFIAIGT 178 V+ G + D C + ++ VV FGE + S++D+F+ IG+ Sbjct: 147 NADVILPKGLIPWIDIPKCPKCGGLIKLDVVLFGEELEKEKFEKAFEVASISDVFLVIGS 206 Query: 179 SGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLK 234 S V PA +AK++ A +N ++ N G + ++P+ VE +++ Sbjct: 207 SLEVMPANALPRKAKMNSATVAYINKTITRFDNYADYVIRGESDYLIPKIVEYVIE 262 >UniRef50_A7SK95 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7SK95_NEMVE Length = 323 Score = 94.4 bits (233), Expect = 3e-18, Method: Compositional matrix adjust. Identities = 85/272 (31%), Positives = 123/272 (45%), Gaps = 58/272 (21%) Query: 2 EKPRVLVLTGAGISAESGIRTFRA-ADGLWE-------EHRVEDVATPEGFDRDPELVQA 53 E P++ V+TGAGIS ESGIR +R+ GL+ E++V F + + Q Sbjct: 59 ENPKIFVITGAGISTESGIRDYRSEGKGLYAITNDRPMEYQV--------FLKSAVMRQR 110 Query: 54 FYNARRRQLQQPEI---QPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMH 110 ++ R + PE QPN AH ALAKL+ LG LVTQN+D LH +AG+ NVI +H Sbjct: 111 YWA--RNYVGWPEFGSRQPNEAHYALAKLE-TLGSVHSLVTQNVDALHTKAGSKNVIELH 167 Query: 111 GELLKVRCSQSGQVL--------------DW---------------TGDVTPEDK---CH 138 G +V C Q+ DW T + + K C Sbjct: 168 GCSHRVICLGCNQITARTALQKRMIEFNPDWHAVGQGQAPDGDTFLTSEAVKDFKVPPCK 227 Query: 139 CCQFPAPLRPHVVWFGE-MPLGMDEI-YMALSMADIFIAIGTSGHVYPAAGFVHEAKLHG 196 C L+P VV+FG+ +P + I Y L+ +D IG++ VY + F EA G Sbjct: 228 AC--GGILKPEVVFFGDSVPKQIVNIAYDRLAESDALWIIGSTVEVYSSYRFATEASKQG 285 Query: 197 AHTVELNLEPSQVGNEFAEKYYGPASQVVPEF 228 LN+ ++ + K G V+P+ Sbjct: 286 KPIAILNIGKTRADKLASLKVSGVCGTVLPKL 317 >UniRef50_Q4ZNC3 Silent information regulator protein Sir2 n=1 Tax=Pseudomonas syringae pv. syringae B728a RepID=Q4ZNC3_PSEU2 Length = 131 Score = 94.0 bits (232), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 48/113 (42%), Positives = 73/113 (64%), Gaps = 4/113 (3%) Query: 2 EKPRVLVLTGAGISAESGIRTFR-AADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 + P +++ TGAGISAESGI T+ G W + ++ T + F +P LV +Y RR+ Sbjct: 13 QAPEIVIFTGAGISAESGIPTYNDPLTGTWASYDPRNMETAKAFRENPPLVWGWYLWRRQ 72 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGEL 113 Q+ + PN AHLA+++L + G ++TQNID+LHERAG+ +V+H+HG L Sbjct: 73 QVSK--AAPNDAHLAVSRLAKS-GYNVSVITQNIDDLHERAGSVDVLHLHGSL 122 >UniRef50_Q73KE1 NAD-dependent deacetylase n=2 Tax=Treponema RepID=NPD_TREDE Length = 251 Score = 94.0 bits (232), Expect = 4e-18, Method: Compositional matrix adjust. Identities = 68/214 (31%), Positives = 105/214 (49%), Gaps = 9/214 (4%) Query: 1 MEKPRVLV-LTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARR 59 + K R LV TGAGIS +GI+ FR DGL+++ E + + F RDP + A+ Sbjct: 15 ITKARHLVAFTGAGISTLAGIKDFRGKDGLYKQPNTEKMFDIDVFYRDPSVYYGM--AKE 72 Query: 60 RQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGEL---LKV 116 E QP H LA L+ G ++TQNID LH++AG+ NVI +HG + Sbjct: 73 FIYGLEEKQPAIVHTVLADLEKR-GILKAVITQNIDLLHQKAGSKNVIEVHGSPSVHYCI 131 Query: 117 RCSQSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGE-MP-LGMDEIYMALSMADIFI 174 CS + + + C + +P++P + +FGE +P + + S +D + Sbjct: 132 NCSYTETFEETAKTAKTGEVPRCPKCGSPIKPAITFFGEALPQKALMKAETEASKSDFML 191 Query: 175 AIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQ 208 +GTS VYPAA +G +N +P+Q Sbjct: 192 VLGTSLLVYPAAALPAYTLRNGGKIAIVNNQPTQ 225 >UniRef50_B3T8H4 Putative Sir2 family protein n=1 Tax=uncultured marine microorganism HF4000_APKG5H11 RepID=B3T8H4_9ZZZZ Length = 273 Score = 93.6 bits (231), Expect = 5e-18, Method: Compositional matrix adjust. Identities = 73/240 (30%), Positives = 112/240 (46%), Gaps = 34/240 (14%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQP 65 V+VL GAG+S ESGI FR GLW ++ + F +DP + ++ AR R +P Sbjct: 25 VVVLAGAGLSVESGIPPFRGPGGLWTKYGEPTNLSYHEFTKDP---KEWWEARFRNEDRP 81 Query: 66 ------------EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGEL 113 + +PN H AL +++ A+G ++TQN+DNLH AG+ +++ +HG Sbjct: 82 GDPTYELKVAVDQARPNPGHHALVEME-AMGLLKCVITQNVDNLHREAGSNSLLEIHGNG 140 Query: 114 LKVRCSQSGQVLDWTGDVTPEDKCH-------CCQFPAPLRPHVVWFGEMPLGMDEIYMA 166 +RC G P D H C Q ++ V FGE P+ D + + Sbjct: 141 TWLRCVGCGV-------RQPRDGYHFDSLPPICTQCGGVIKMDTVMFGE-PIPEDVLLAS 192 Query: 167 LSMA---DIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQ 223 A D + +GTSG V PAA AK GA +E+N + + + GP+ + Sbjct: 193 REQAEACDCMLLVGTSGTVNPAARLPLVAKELGATLIEINPDETTLTPSCDITLNGPSGE 252 >UniRef50_B4VCV9 SIR2 family transcriptional regulator n=3 Tax=Actinomycetales RepID=B4VCV9_9ACTO Length = 241 Score = 93.2 bits (230), Expect = 6e-18, Method: Compositional matrix adjust. Identities = 77/246 (31%), Positives = 116/246 (47%), Gaps = 21/246 (8%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAADGLW-EEHRVEDVATPEGFDRDPELVQAFYNARR 59 M KP V V +GAG+S +SGI +R GLW + E + T E + DPE+ + + R Sbjct: 1 MGKPLVAVFSGAGMSTDSGIPDYRGPQGLWRRDPDAEKLVTYEYYMADPEIRRRSWRM-R 59 Query: 60 RQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELLKVR 117 ++ +PNAAH A+A+L D G ++TQN+D LH+ AG V +HG V Sbjct: 60 AEIGALGARPNAAHRAVAEL-DRGGTPVRVITQNVDGLHQLAGMPARKVFELHGTARSVL 118 Query: 118 CS----QSG--QVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMA- 170 C+ +SG + L P+ C C L+ V FGE +D +A ++A Sbjct: 119 CTACHARSGMEEALARVAAGEPDPACLACG--GILKSATVMFGER---LDPQVLAQAVAV 173 Query: 171 ----DIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVP 226 +FIA+GT+ V PAA A GA + +N E + E P +P Sbjct: 174 AKGCQVFIAVGTTLQVQPAASLAGMAATAGARLIIVNAEETPYDELADEVIREPIGTALP 233 Query: 227 EFVEKL 232 + ++ Sbjct: 234 ALLTRI 239 >UniRef50_Q67KQ0 NAD-dependent deacetylase n=1 Tax=Symbiobacterium thermophilum RepID=NPD_SYMTH Length = 251 Score = 93.2 bits (230), Expect = 7e-18, Method: Compositional matrix adjust. Identities = 74/208 (35%), Positives = 102/208 (49%), Gaps = 11/208 (5%) Query: 7 LVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQPE 66 + LTGAG S ESG+ FR+ GLW++ + + R P FY R L Sbjct: 19 VALTGAGASTESGLPDFRSNTGLWKDVDPVSLISMTALRRRPVDFYRFYRMRFSHLWG-- 76 Query: 67 IQPNAAHLALAKLQ-DALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVL 125 QPN H LA LQ + L R L+TQN+D LH+ AG+ +VI +HG L + +C + G+ Sbjct: 77 AQPNPVHKVLAALQREGLLKR--LITQNVDGLHQAAGSPDVIELHGSLRECQCLRCGRRF 134 Query: 126 -DWTGDV---TPEDKCHCCQFPAPLRPHVVWFGE-MPLGMDEIYMALSM-ADIFIAIGTS 179 DV T D C + L+P VV F E +P E + +M AD+F+ +G+S Sbjct: 135 PSRLIDVEVETEADIPRCPECGGVLKPGVVLFEEALPADAIEAAIEAAMKADLFLVVGSS 194 Query: 180 GHVYPAAGFVHEAKLHGAHTVELNLEPS 207 V PA A HG NL P+ Sbjct: 195 LEVGPANQLPVLAVQHGGRLAIFNLTPT 222 >UniRef50_B2A496 Silent information regulator protein Sir2 n=1 Tax=Natranaerobius thermophilus JW/NM-WN-LF RepID=B2A496_NATTJ Length = 252 Score = 93.2 bits (230), Expect = 8e-18, Method: Compositional matrix adjust. Identities = 69/188 (36%), Positives = 91/188 (48%), Gaps = 10/188 (5%) Query: 8 VLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQPEI 67 VLTGAGIS ESGI FR DGLW + +T E PE + R +QL E Sbjct: 22 VLTGAGISTESGIPDFRGKDGLWTKIDPMQYSTREVLMSVPEKFYEYGFERFKQLANKE- 80 Query: 68 QPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLK---VRCSQSGQV 124 PN H LA L+ G +VTQNID LH++AG+ V +HG K + C+Q Sbjct: 81 -PNQGHKILADLEKH-GVISGIVTQNIDGLHQKAGSKQVFEVHGNTRKCYCLGCNQEYPF 138 Query: 125 LDWTGDVTPEDKC--HCCQFPAPLRPHVVWFG-EMPLGMDEIYMALSM-ADIFIAIGTSG 180 + + + E K C + LRP ++ FG +MP ++ L D + IGTS Sbjct: 139 QELSDQLEKEQKDVPKCKECGGMLRPDIILFGDQMPDLFFKVTTVLKQRCDFLLVIGTSL 198 Query: 181 HVYPAAGF 188 VYP A Sbjct: 199 QVYPVAAL 206 >UniRef50_C4XFR7 Putative uncharacterized protein n=1 Tax=Mycoplasma fermentans PG18 RepID=C4XFR7_MYCFE Length = 251 Score = 92.8 bits (229), Expect = 8e-18, Method: Compositional matrix adjust. Identities = 67/226 (29%), Positives = 111/226 (49%), Gaps = 23/226 (10%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 E ++ +GAG+S SGI FR+ADGL+ + + +++ PE L ++F+ ++ Sbjct: 18 ESKHIVFFSGAGVSTASGIPDFRSADGLYSK-KFKNM-NPESI-----LSRSFWRKNKKD 70 Query: 62 LQQ--------PEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGEL 113 + I+PN H +A + ++ ++TQNIDNL +AGN VI +HG + Sbjct: 71 FYEYYFSNIAFDNIKPNIIHETVASWCNK--NKCHVITQNIDNLDIKAGNKYVIELHGNI 128 Query: 114 LKVRCSQSGQVLDWTGDVTPEDK--CHCCQFPAPLRPHVVWFGE--MPLGMDEIYMALSM 169 + C G+ D + +DK C+ + P VV + + M ++ A+S Sbjct: 129 NRNYCLLCGKFYDLAQLIHQKDKDGIPTCKCGGVINPDVVLYEDPLMEDSTNDAAEAISN 188 Query: 170 ADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAE 215 +D+ I GTS VYPAA ++H G V LN + S+ N E Sbjct: 189 SDLLIIAGTSLSVYPAASYIHF--YQGKRIVILNKDTSRYENSNNE 232 >UniRef50_B1MX21 NAD-dependent protein deacetylase, SIR2 family n=5 Tax=Leuconostocaceae RepID=B1MX21_LEUCK Length = 238 Score = 92.8 bits (229), Expect = 9e-18, Method: Compositional matrix adjust. Identities = 62/204 (30%), Positives = 106/204 (51%), Gaps = 14/204 (6%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHRV--EDVATPEGFDRDPELVQAFYNARRRQLQ 63 +L +TGAGIS SGI +R+ +G+++ R+ E + + F +P L Q Y + Sbjct: 21 ILFMTGAGISTASGIPDYRSKNGIYQGVRLRPEYLLSATAFQNEP-LKQ--YQFMIDNMY 77 Query: 64 QPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGN--TNVIHMHGELLKVRCSQS 121 P +PN H +A+L +R ++TQN+D+LH +A + N+I HG L + + Sbjct: 78 FPAAEPNVIHEKMAEL--TRQNRAKIITQNVDDLHVKAKSQAANLIRFHGSLYDIYAPKD 135 Query: 122 GQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGH 181 GQ + + + + A LRP + ++ EMP +++ + AD+ + +GTS Sbjct: 136 GQKANLSAYMKSPKRADG----AMLRPRITFYEEMPFEVEKSAAWVQAADLIVIVGTSFQ 191 Query: 182 VYPAAGFVHEAKLHGAHTVELNLE 205 VYP AG ++ AK + +NLE Sbjct: 192 VYPFAGLLNFAK-PDVPVIAINLE 214 >UniRef50_C1VAT1 NAD-dependent protein deacetylase, SIR2 family n=1 Tax=Halogeometricum borinquense DSM 11551 RepID=C1VAT1_9EURY Length = 270 Score = 92.8 bits (229), Expect = 9e-18, Method: Compositional matrix adjust. Identities = 76/240 (31%), Positives = 109/240 (45%), Gaps = 20/240 (8%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNAR---RRQL 62 V VLTGAG+S SG+ TFR +G+W + F+RDP F+ R ++ Sbjct: 18 VTVLTGAGVSNASGVPTFRGEEGIWNNEFDPADFRMDRFERDP---AGFWTDRLELHERM 74 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG 122 PN AH ALA+L+D LG ++VTQN D LH AG +I +HG + C + G Sbjct: 75 FGDVTGPNDAHRALARLED-LGVVDVVVTQNTDGLHAEAGTNRLIELHGNNARSVCVECG 133 Query: 123 Q------VLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGE-MPLG-MDEIYMALSMADIFI 174 + LD C L+P VV FGE +P G D +D+FI Sbjct: 134 ESVPTETALDDVRAGNSPPSCPVVGCTGHLKPDVVLFGERLPGGAYDSARRMAWESDVFI 193 Query: 175 AIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYY--GPASQVVPEFVEKL 232 +G+S V PA+ EA G + + + + Y G A++ +P VE + Sbjct: 194 VVGSSLTVVPASTLPEEAAERGQLAI---FDTGETEKDHLAHYLVRGDATETLPALVEAV 250 >UniRef50_C5CGD1 Silent information regulator protein Sir2 n=3 Tax=Thermotogaceae RepID=C5CGD1_KOSOT Length = 249 Score = 92.0 bits (227), Expect = 1e-17, Method: Compositional matrix adjust. Identities = 78/214 (36%), Positives = 107/214 (50%), Gaps = 24/214 (11%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEG-FDRDPELVQ--AFYN-A 57 E +LTGAG+S SGI FR GL+++ P+ FD D L Q +Y A Sbjct: 16 ESESTAILTGAGVSTASGIPDFRGPQGLYKK-------LPQYIFDLDFFLSQPAEYYKIA 68 Query: 58 RRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVR 117 R +PNA H LA L+ G ++TQNID LH++AG+ VI +HG K Sbjct: 69 ADRIHNLFNKEPNATHRLLAMLEKK-GMIEGVITQNIDGLHQKAGSKKVIELHGNAQKFF 127 Query: 118 CSQSGQ------VLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGE-MP-LGMDEIYMALSM 169 C G+ VL +V+ KC C ++P VV+FGE +P M E Y+ Sbjct: 128 CMSCGKRYTAEDVLKML-EVSDVPKCTCGGL---IKPDVVFFGEALPESAMAEAYILSEN 183 Query: 170 ADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELN 203 A++FI +G+S VYPAA AK GA + +N Sbjct: 184 AELFITMGSSLVVYPAAHLPTFAKQKGAKLLIIN 217 >UniRef50_Q5V4Q5 NAD-dependent deacetylase n=3 Tax=Halobacteriaceae RepID=NPD_HALMA Length = 260 Score = 92.0 bits (227), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 86/244 (35%), Positives = 117/244 (47%), Gaps = 31/244 (12%) Query: 7 LVLTGAGISAESGIRTFRAADGLWEEHRVEDV------ATPEGFDRDP-ELVQAFYNARR 59 + LTGAG+S SGI +FR DG+WE H D A P GF D L +A Y Sbjct: 30 VALTGAGVSTASGIPSFRGDDGIWERHDPADFHRRRLDADPAGFWADRLSLREAIYG--- 86 Query: 60 RQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCS 119 + +PNAAH ALA L+ A G ++TQNID LH+ AG V+ +HG +V C Sbjct: 87 ----DIDPEPNAAHEALAALE-ADGHLDAVLTQNIDGLHDAAGTDRVVELHGTHRRVVCD 141 Query: 120 QSGQVLDW---------TGDVTPEDKCHCCQFPAPLRPHVVWFGE-MP-LGMDEIYMALS 168 G D + D+ P +C C RP VV FGE MP + M+E Sbjct: 142 DCGHRRDAEVVFEQAAESSDLPP--RCDCGGV---YRPDVVLFGEPMPDVAMNEAQRLAR 196 Query: 169 MADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEF 228 +D+F+A+G+S V PA+ A + V +N E + A +QV+P Sbjct: 197 DSDVFLAVGSSLSVQPASLLPKIAAEGDSTLVVVNYEETPRDASAAHVLRADVTQVLPAI 256 Query: 229 VEKL 232 VE+L Sbjct: 257 VERL 260 >UniRef50_D2Q7L2 SIR2 family protein n=13 Tax=Bifidobacterium RepID=D2Q7L2_9BIFI Length = 254 Score = 91.7 bits (226), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 77/227 (33%), Positives = 110/227 (48%), Gaps = 31/227 (13%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEH----RVEDVATPEGFDRDPELVQAFYNARRR 60 ++ VLTGAGIS +GI FR DG+W +H V D+ + D E + R Sbjct: 4 KIAVLTGAGISTSAGIPDFRGPDGVWTKHPEQMNVYDIDAFLANEEDREY------SWRW 57 Query: 61 QLQQP--EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTN--VIHMHGELLKV 116 Q + P QP AH AL KL+ A G LL TQN D LHE+AGN++ ++++HG + Sbjct: 58 QKESPVWNAQPGEAHKALVKLEQA-GMLTLLATQNFDALHEKAGNSDNVIVNLHGTIGTS 116 Query: 117 RCSQSGQVLDWTGDVT------PEDKCH-----CCQFPAP--LRPHVVWFGE-MPLG-MD 161 C + D T D+ P+ CH P ++ VV+FGE +P G M+ Sbjct: 117 HCMKCHAKYD-TADIMANLDNEPDPHCHRKLPYSGNMPCNGLIKTDVVYFGEALPDGAME 175 Query: 162 EIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQ 208 + Y + AD IG++ V PAA V A G +N+ +Q Sbjct: 176 KSYRLATQADELWVIGSTLEVMPAASIVPVAAQAGVPITIMNMGHTQ 222 >UniRef50_B1I1N5 Silent information regulator protein Sir2 n=1 Tax=Candidatus Desulforudis audaxviator MP104C RepID=B1I1N5_DESAP Length = 249 Score = 91.3 bits (225), Expect = 2e-17, Method: Compositional matrix adjust. Identities = 84/246 (34%), Positives = 117/246 (47%), Gaps = 33/246 (13%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEGFDRDPELVQAFYNAR-R 59 E R L LTGAGIS SGI FR+ G WE+ +V++ + F RDP AF+ + Sbjct: 18 ESARTLALTGAGISTASGIPDFRSRGVGRWEKVDPMEVSSVQAFQRDPA---AFWRYNLK 74 Query: 60 RQLQQPEIQPNAAHLALAKLQDALGDRFLL---VTQNIDNLHERAGNTNVIHMHGELLKV 116 L+ + +PN AH LA L+ R LL +TQN+D LH RAG + +HG L Sbjct: 75 WWLEFADAEPNPAHHVLATLE----RRKLLQGVITQNVDGLHVRAG-SQTWEVHGHLRTC 129 Query: 117 RCSQSGQVLDWT--------GDVTPEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMA 166 RC G ++T G P +C C A LRP VV FG+M LG ++ Sbjct: 130 RCLGCGGRYEFTFLVEQFQAGKNPP--RCPC---GALLRPDVVLFGDM-LGDAFEQAVQV 183 Query: 167 LSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVP 226 L + I +G+S VYP A A+ V +N +P+ ++ A G QV Sbjct: 184 LHGCPLLIVVGSSLQVYPVAALPRLAR----RLVIINRDPTPWDDQAALILRGDIVQVFE 239 Query: 227 EFVEKL 232 + +L Sbjct: 240 KLAAEL 245 >UniRef50_D2RCH9 Transcriptional regulator, Sir2 family n=7 Tax=Bifidobacteriaceae RepID=D2RCH9_GARVA Length = 257 Score = 90.5 bits (223), Expect = 4e-17, Method: Compositional matrix adjust. Identities = 86/265 (32%), Positives = 123/265 (46%), Gaps = 49/265 (18%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEG---FDRDPELVQAFYNAR---- 58 ++VLTGAGIS +GI FR DG+W +H PE +D D AF +++ Sbjct: 13 IVVLTGAGISTSAGIPDFRGPDGVWTKH-------PEQMSVYDID-----AFLSSKEERV 60 Query: 59 ---RRQLQQP--EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTN--VIHMHG 111 R Q + P QP AH AL KL+ A G L+ TQN D LHE+AGN ++++HG Sbjct: 61 YSWRWQKESPVWNAQPGTAHKALVKLEKA-GMLDLIATQNFDALHEKAGNNPDIIVNLHG 119 Query: 112 ELLK---VRCSQSGQVLDWTGDVTPEDKCHC-------CQFPAP--LRPHVVWFGE-MPL 158 + + C S + D D+ HC P ++ VV+FGE +P Sbjct: 120 SIGTSHCMSCHASYKTADIMADLDEHPDPHCRRTLPYRSNMPCNGLIKTDVVYFGEALPE 179 Query: 159 G-MDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKY 217 G M+ A+ AD IG++ V+PAA V A G +NL +Q Y Sbjct: 180 GAMERSAQAIVKADELWVIGSTLEVFPAASLVPLAARAGVPITIMNLGSTQ--------Y 231 Query: 218 YGPASQVVPEFVEKLLKGLKAGSIA 242 A +++ E + K L L +IA Sbjct: 232 DYLAERIIREDIAKALPKLVDETIA 256 >UniRef50_UPI0001C3128D Silent information regulator protein Sir2 n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C3128D Length = 256 Score = 90.5 bits (223), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 73/224 (32%), Positives = 101/224 (45%), Gaps = 16/224 (7%) Query: 6 VLVLTGAGISAESGIRTFRAA-DGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQ 64 V+ LTGAGIS SGI FR GLW +VA + + D AFY R + L+ Sbjct: 22 VVALTGAGISVPSGIPDFRTPRTGLWANVDPMEVAHIDAWRNDAARFWAFYGHRFQSLR- 80 Query: 65 PEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQV 124 + +PN AH LA+L+ G ++TQNID LHERAG ++I +HG + C G Sbjct: 81 -DKRPNRAHEVLAELERR-GIVETVITQNIDQLHERAGVADLIELHGSIAHSSCLACGAR 138 Query: 125 LDWT-------GDVTPEDKCHCCQFPAPLRPHVVWFGEM--PLGMDEIYMALSMADIFIA 175 D +C C + PL+P VV FGE+ G++ AD+ + Sbjct: 139 YPLAEVQARLEQDPQGVPRCDCGR---PLKPDVVLFGELLPQAGLERAQTLALRADLLLC 195 Query: 176 IGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYG 219 IG+S VYP G L P++ + K G Sbjct: 196 IGSSLEVYPVGELPSLTLRAGGEIAILTQGPTRYDRDAVVKLDG 239 >UniRef50_C5DRF3 ZYRO0B08008p n=1 Tax=Zygosaccharomyces rouxii RepID=C5DRF3_ZYGRO Length = 345 Score = 90.1 bits (222), Expect = 5e-17, Method: Compositional matrix adjust. Identities = 47/120 (39%), Positives = 73/120 (60%), Gaps = 7/120 (5%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQ 64 ++L + GAG+S SGI T++ G W+ + D+ATPE F +P LV FY+ RR + Sbjct: 29 KILCVVGAGLSQSSGIPTYQLQRGTWKGYTSIDLATPEAFQTNPGLVWLFYSNRRYIAMK 88 Query: 65 PEIQPNAAHLALAKLQDALGDR---FLLVTQNIDNLHERAG--NTNVIHMHGELLKVRCS 119 +PN H ALA+L + +R +VTQN+D LH+RAG + ++ +HG L ++RC+ Sbjct: 89 --ARPNEGHFALAELAKRMKERRREAFVVTQNVDGLHQRAGQEDADLCELHGSLFQLRCT 146 Score = 47.8 bits (112), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 37/120 (30%), Positives = 54/120 (45%), Gaps = 13/120 (10%) Query: 96 NLHERAGNTNVIHMHGELLKVRCSQSGQVLDWTGDVTPEDKCHC--CQFPAPLRPHVVWF 153 L +R ++ E ++ S S D ++ E+ HC C LRP +VWF Sbjct: 186 TLGKRRKKSSTPIQKKEYVENEDSVSSSDFDPLPEIKEENLPHCPVCH-EGLLRPGIVWF 244 Query: 154 GE-MPL----GMDEIYM-----ALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELN 203 GE +PL +DE + A D+ + IGTSG V+PA G+V K +G N Sbjct: 245 GEPLPLMDMVKVDEFFAPQEEGANDHIDLVLVIGTSGKVWPAMGYVERCKQNGGRVAIFN 304 >UniRef50_A5UYK2 Silent information regulator protein Sir2 n=2 Tax=Roseiflexus RepID=A5UYK2_ROSS1 Length = 261 Score = 89.4 bits (220), Expect = 9e-17, Method: Compositional matrix adjust. Identities = 80/234 (34%), Positives = 113/234 (48%), Gaps = 17/234 (7%) Query: 7 LVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQP- 65 + +TGAGIS SGI FR DG W+ +VA+ F R+P +AFY+ R L + Sbjct: 25 VAITGAGISTPSGIPDFRGPDGAWKHVDPSEVASLHNFLRNP---RAFYDWFRPLLDRVL 81 Query: 66 EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVL 125 PNAAH ALA L+ R ++TQN D LH+RAG+ V +HG L C + + + Sbjct: 82 AAAPNAAHYALAALEQHRTLR-AIITQNFDGLHQRAGSREVYELHGHLRTATCLECERQI 140 Query: 126 DWTGDVTPE------DKCHCCQFPAPLRPHVVWFGEM-PLGMDEI-YMALSMADIFIAIG 177 T + P +C C PL+P VV F EM P G+ + A+ AD+ I G Sbjct: 141 P-TQALLPRIRRGEPPRCSCGH---PLKPDVVLFDEMLPRGLYWLARRAVEHADVIIVAG 196 Query: 178 TSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEK 231 TS V+P HGA + +N P+ + G + +PE V + Sbjct: 197 TSLEVFPVNDLPALGLRHGAKLIIINNGPTYLDGRAEAVIRGDVAIALPELVRQ 250 >UniRef50_A0NQ49 Silent information regulator protein Sir2 n=2 Tax=Labrenzia RepID=A0NQ49_9RHOB Length = 260 Score = 89.4 bits (220), Expect = 9e-17, Method: Compositional matrix adjust. Identities = 77/248 (31%), Positives = 113/248 (45%), Gaps = 33/248 (13%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLW--------------EEHRVEDVATP-EGFDRDPE 49 +++ LTGAGIS ESGI FR+ G+W E+ R+ED E +DR E Sbjct: 24 QIVALTGAGISTESGIPDFRSPGGIWSKRQPVQYQDFVDDEDSRLEDWDRRLEDWDRRSE 83 Query: 50 LVQAFYNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVI 107 ++ F A +PNAAH AL L + G L+TQN+D LH+RAG + ++ Sbjct: 84 MMDYFCKA----------EPNAAHFALTTLARS-GKLVCLITQNVDGLHQRAGFPDDLLV 132 Query: 108 HMHGELLKVRCSQSGQVLDWTGD---VTPEDKCHCCQFPAPLRPHVVWFG-EMP-LGMDE 162 +HG C G + V + C Q L+ V+ FG +MP + Sbjct: 133 EIHGNSTFASCLSCGARAELEAQKPAVDAGESPRCSQCDGLLKAAVISFGQQMPERELQR 192 Query: 163 IYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPAS 222 A S D+F+ +G+S V+PAA A GA V LN + + + + + P + Sbjct: 193 AAEAASACDLFLVLGSSLVVHPAAQLPAVAVQSGAELVILNGQETPLDSYASTIVRTPLA 252 Query: 223 QVVPEFVE 230 Q F E Sbjct: 253 QTFAGFGE 260 >UniRef50_C1SNI0 NAD-dependent protein deacetylase, SIR2 family n=1 Tax=Denitrovibrio acetiphilus DSM 12809 RepID=C1SNI0_9BACT Length = 256 Score = 89.0 bits (219), Expect = 1e-16, Method: Compositional matrix adjust. Identities = 68/216 (31%), Positives = 104/216 (48%), Gaps = 24/216 (11%) Query: 2 EKPRVLVLTGAGISAESGIRTFRA-ADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 + P + TGAG S ESGI +R+ GLW + + +GF +P + FY Sbjct: 18 DNPYNVFFTGAGASTESGIPDYRSEGSGLWNRIDSSKLISLKGFLENP---KGFYEVFSG 74 Query: 61 QLQQP--EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRC 118 L P +PN AH+ +A L++ + ++TQNID LH +AG+ N+ +HG + C Sbjct: 75 GLFAPFAHAEPNVAHMFIAMLEEQKASK-AVITQNIDGLHRKAGSFNICELHGSMETSSC 133 Query: 119 SQSGQVLDWTGDV---------TPEDKCHCCQFPAPLRPHVVWFGE-MPLG-MDEIYMAL 167 G+ T +V TPE C C ++P +V+FGE +P ++E + Sbjct: 134 IICGKSFS-TAEVFDKFMLDGATPE--CTCGNI---VKPDIVFFGESLPKDVLEESFELA 187 Query: 168 SMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELN 203 + + I G+S V PA AK HGA V +N Sbjct: 188 AGCTLMIVAGSSLEVMPANLLPKYAKDHGALLVIIN 223 >UniRef50_C8W9D8 Silent information regulator protein Sir2 n=2 Tax=Atopobium RepID=C8W9D8_ATOPD Length = 283 Score = 88.6 bits (218), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 76/252 (30%), Positives = 109/252 (43%), Gaps = 55/252 (21%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEH--RVEDVAT---PEGFDRDPELVQ------- 52 ++ GAG+S ESGI FR +GL+ + ++E++ +G+D E Sbjct: 16 NIVFFGGAGVSTESGIPDFRGTNGLYRQGGIKIENMTIGLGQDGYDMGKETCDLGNGITV 75 Query: 53 --------------------------------AFYNARRRQLQQPEIQPNAAHLALAKLQ 80 A+Y R E QPN AH LA L+ Sbjct: 76 DPDNEESFAYSKAPDFTLEEIFSLDVFLDYPAAYYTYFRNSHHLGEAQPNIAHKWLAALE 135 Query: 81 DALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVLDWTGDVTPEDKCHC- 139 A G +VTQNID LH+ AG+ V +HG + C + G V +T D E Sbjct: 136 -AEGKLRAVVTQNIDGLHQAAGSKRVFELHGNETRFYCPECGHV--YTLDQIEEQSSVVP 192 Query: 140 -CQFPAPLRPHVVWFGEMPLGMDEIYMAL---SMADIFIAIGTSGHVYPAAGFVHEAKLH 195 CQ A +RP +V++GE L MD +Y AL S A++ I G+S V PA G + Sbjct: 193 LCQCGAVIRPDIVFYGE-GLNMDTVYGALNAISQAEVLIVAGSSLVVQPAVGLLD--YYE 249 Query: 196 GAHTVELNLEPS 207 G V +N +P+ Sbjct: 250 GNKMVIINDQPT 261 >UniRef50_Q5KZE8 NAD-dependent deacetylase 2 n=8 Tax=Bacteria RepID=NPD2_GEOKA Length = 247 Score = 88.2 bits (217), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 75/231 (32%), Positives = 113/231 (48%), Gaps = 13/231 (5%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLW-EEHRVEDVATPEGFDRDPELVQAFYNARRR 60 E + VLTGAG+S ESGI FR+ +GL+ +E VE + + +DP F+ +R Sbjct: 13 EANTIAVLTGAGMSTESGIPDFRSENGLYAQEDNVEYYLSEYYYKKDP---VDFWRRFKR 69 Query: 61 QLQQPEI---QPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVR 117 + PN H L L++ +G ++TQNID LH +AG+TNVI +HG L Sbjct: 70 MFSLKMMGGFAPNDGHRFLRWLEE-MGKTVTILTQNIDGLHTKAGSTNVIELHGTLQTAT 128 Query: 118 CSQSGQVLDWTGDVTPE-DKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAI 176 C G D + E +C CQ ++P VV FG + M+E + A + +D+ +A+ Sbjct: 129 CPSCGNKYDLSFINRHEVPRCEKCQ--TIVKPDVVLFGGLVPRMEEAFAAAAASDLLLAM 186 Query: 177 GTSGHVYPAAG--FVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVV 225 GTS V P F A+ V +N +++ F YG + V Sbjct: 187 GTSLEVAPVNQIPFYVAAESPATRKVLINKTATRMDGMFDLVIYGGIGKTV 237 >UniRef50_Q8R984 NAD-dependent deacetylase 2 n=9 Tax=Thermoanaerobacter RepID=NPD2_THETN Length = 250 Score = 88.2 bits (217), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 66/190 (34%), Positives = 96/190 (50%), Gaps = 15/190 (7%) Query: 5 RVLVLTGAGISAESGIRTFRA-ADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQ 63 + +VLTGAGIS ESGI FR+ GLWE +V + + PE FY + L Sbjct: 22 KTMVLTGAGISTESGIPDFRSPGTGLWENMDPTEVLSTKVLFNSPE---EFYRVGFKILS 78 Query: 64 Q-PEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG 122 +PN AH L++++ G ++TQNIDNLH++AG+ V +HG + C + G Sbjct: 79 SMRNAEPNEAHYILSEMEKE-GIIAGVITQNIDNLHQKAGSKKVYEVHGNTREGSCLRCG 137 Query: 123 QVLDW---TGDVTPED---KCHCCQFPAPLRPHVVWFGE-MPLGMDEIYMALSMADIFIA 175 + + + V E+ +C C LRP VV FG+ MP D + +D+ I Sbjct: 138 EKVSFELLEEKVAKEEIPPRCDRCG--GMLRPDVVLFGDPMPHAFDLALKEVQESDLLIV 195 Query: 176 IGTSGHVYPA 185 IG+S V P Sbjct: 196 IGSSLVVAPV 205 >UniRef50_C2H995 NAD-dependent deacetylase (SIR2 family regulatory protein) n=16 Tax=Enterococcus RepID=C2H995_ENTFC Length = 241 Score = 88.2 bits (217), Expect = 2e-16, Method: Compositional matrix adjust. Identities = 55/188 (29%), Positives = 98/188 (52%), Gaps = 12/188 (6%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWE-EHRVEDVATPEGFDRDPELVQAFYNARRRQLQ 63 ++ LTGAG+S SG+ +R+ G++ + E + + + +P+ FY ++ + Sbjct: 18 KITFLTGAGVSTPSGVPDYRSLTGIYHGMEQPEYLLSHQAMVNEPD---KFYQFVKK-IY 73 Query: 64 QPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQ 123 PE +PN HL +A L A +V+QNID LH +A + +++ HG L + C + Q Sbjct: 74 HPEAKPNIIHLEMAHL--AKEKNIWVVSQNIDGLHAKAKSPQLVNFHGSLYQCHCRKCKQ 131 Query: 124 VLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGE--MPLGMDEIYMALSMADIFIAIGTSGH 181 +DW + DK C +RP++V +GE +++ A+S A++ + +GTS Sbjct: 132 TVDWK-EYLHSDKHQAC--GGQIRPNIVLYGEGFQDEVIEQAAYAVSQAELVVIVGTSFQ 188 Query: 182 VYPAAGFV 189 V+P V Sbjct: 189 VHPFCDLV 196 >UniRef50_D1N1D6 Silent information regulator protein Sir2 n=1 Tax=Victivallis vadensis ATCC BAA-548 RepID=D1N1D6_9BACT Length = 248 Score = 87.4 bits (215), Expect = 4e-16, Method: Compositional matrix adjust. Identities = 69/228 (30%), Positives = 110/228 (48%), Gaps = 19/228 (8%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGL----WEEHRVEDVATPEGFDRDPELVQAFYNA 57 E R L TGAGIS SGIR FR +G+ W VE++ + + F +P L + Sbjct: 11 ESRRTLAFTGAGISTLSGIRDFRGKNGVYLEPWHGKSVEEILSLDCFLAEPALFYGWAAE 70 Query: 58 RRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVR 117 +L+ E P A H ALA L+ + G + TQNID LH++AG+ +V +HG + Sbjct: 71 FLYRLE--EFHPAAVHRALAGLEQS-GLLRGVYTQNIDLLHQQAGSRHVYELHGSPARHH 127 Query: 118 CSQSGQVLDWTGDVTP---EDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMAD--- 171 C + + + ++ P K C ++P +V++GE +DE + + AD Sbjct: 128 CLKCRKQFGYA-EIAPLVLAGKVPRCGCGGLVKPDIVFYGE---NLDEALLNQAFADMEK 183 Query: 172 --IFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKY 217 + + +G+S V PAA A G V +N +P+ + A +Y Sbjct: 184 AELVLVLGSSLTVQPAASLPMAANYGGGKIVIVNAQPTPLDRYAALRY 231 >UniRef50_Q839C6 NAD-dependent deacetylase n=22 Tax=Bacilli RepID=NPD_ENTFA Length = 237 Score = 87.0 bits (214), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 53/189 (28%), Positives = 92/189 (48%), Gaps = 12/189 (6%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEE-HRVEDVATPEGFDRDPELVQAFYNARRRQLQ 63 ++ LTGAGIS SG+ +R+ G+++ + E + + +PE F + L Sbjct: 18 KITFLTGAGISTASGVPDYRSLKGVYQGIQQPEYLLSRTCLKTEPEKFYQFV----KTLY 73 Query: 64 QPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQ 123 P+ QPN H +A+L+ R +V+QNID LH +AG+ V+ HG L + C G Sbjct: 74 HPDAQPNIIHQKMAQLEQM--KRGKIVSQNIDGLHRKAGSQEVVDFHGNLYECYCQTCGA 131 Query: 124 VLDWTGDVTPEDKCHCCQFPAPLRPHVVWF--GEMPLGMDEIYMALSMADIFIAIGTSGH 181 + W + + C +RP + + G +++ A++ AD+ + +GTS Sbjct: 132 TVPWQDYLLSDRHADC---HGQIRPAITLYEEGLSEEAIEKAIQAVASADLIVIVGTSFQ 188 Query: 182 VYPAAGFVH 190 V+P +H Sbjct: 189 VHPFCDLIH 197 >UniRef50_D2RWQ5 Silent information regulator protein Sir2 n=2 Tax=Halobacteriaceae RepID=D2RWQ5_9EURY Length = 271 Score = 87.0 bits (214), Expect = 5e-16, Method: Compositional matrix adjust. Identities = 82/261 (31%), Positives = 118/261 (45%), Gaps = 46/261 (17%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNAR---RRQL 62 V+ TGAGISA SG+ TFR G+WE+ E T F DP F++ R +R++ Sbjct: 17 VVAFTGAGISAPSGVPTFRGDGGVWEKFD-EGQFTYGRFRSDP---AGFWDDRVDLQREM 72 Query: 63 QQPEIQPNAAHLALAKL-QDALGDRFLLVTQNIDNLHERAGN------------------ 103 QPNAAH ALA + +D G ++TQN D LH +A + Sbjct: 73 FAEVYQPNAAHEALAAMGRD--GHLEAILTQNTDGLHAQAADAVSGDSSGDSDGADANGD 130 Query: 104 -----TNVIHMHGELLKVRCSQSGQ------VLDWTGDVTPEDKCHCCQFPAPLRPHVVW 152 T ++ +HG +VRC+ G+ V D + C C +P VV Sbjct: 131 AADDNTTLLELHGNARRVRCTDCGRRRDADPVFDRAAEGELPPTCDCGGV---FKPDVVL 187 Query: 153 FGEMPLGMDEIYMALSMA---DIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQV 209 FG+ G I A S+A D+F+A+G+S V PAA +A GA +NLE + V Sbjct: 188 FGQQLPGT-VIQRARSLARESDVFLAVGSSLVVEPAASLPRQAASTGATLGIVNLESTPV 246 Query: 210 GNEFAEKYYGPASQVVPEFVE 230 + ++V+P E Sbjct: 247 DDAADVVRREDVTEVLPRLRE 267 >UniRef50_Q6QGI5 NAD-dependent protein deacetylases SIR2 family n=5 Tax=Caudovirales RepID=Q6QGI5_BPT5 Length = 272 Score = 86.7 bits (213), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 56/194 (28%), Positives = 104/194 (53%), Gaps = 25/194 (12%) Query: 5 RVLVLTGAGISAESGIRTFR----AADGLWEEHRVEDVATPEGFDRD-PELVQAFYNARR 59 R+++++GAG+S ESG+R FR + LW+++ +E+V F + FYN RR Sbjct: 3 RLIIISGAGLSVESGVRAFRTDTASGKALWDDYDLEEVCNIHAFRGNFYHKTHMFYNKRR 62 Query: 60 RQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELLKVR 117 +L+ ++PN AHL + + + + +T N+D+L ERAG +++++H+HG L +V Sbjct: 63 EELKT--VEPNLAHLRIGEWYKKYPGQVVNLTTNVDDLIERAGVPHSDILHIHGYLKEVV 120 Query: 118 C-----SQSGQVLD-WTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYM---ALS 168 S + +V+D + P+D ++P+V++FGE E+Y ++ Sbjct: 121 VADSYNSSNKRVIDVGYNSIDPDDY-------KWVKPNVIFFGEHAPAYTEMYNIFDGIT 173 Query: 169 MADIFIAIGTSGHV 182 D+ + +G S V Sbjct: 174 SQDMIVVVGCSNQV 187 >UniRef50_Q71W25 NAD-dependent deacetylase n=32 Tax=Bacilli RepID=NPD_LISMF Length = 229 Score = 86.7 bits (213), Expect = 7e-16, Method: Compositional matrix adjust. Identities = 59/187 (31%), Positives = 96/187 (51%), Gaps = 21/187 (11%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPE------GFDRDPELVQAFYNARR 59 ++ LTGAG+S SGI +R+ +GL+ +++PE R+PE FY Sbjct: 14 IVFLTGAGVSVPSGIPDYRSKNGLYA-----GMSSPEYMLSHTCLVREPE---KFYQFVT 65 Query: 60 RQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCS 119 + P+ +PNA H +A+++ A D ++TQNID LHE+AG+ V++ HG L C Sbjct: 66 ENMYYPDAEPNAIHTKMAEIE-AEKD-VTIITQNIDGLHEKAGSKKVVNFHGSLYHCYCQ 123 Query: 120 QSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGE-MP-LGMDEIYMALSMADIFIAIG 177 + G + + + C +RP VV + E +P +D+ A+ AD+ + +G Sbjct: 124 KCGMSVTAEEYLKSDIHSGC---GGVIRPDVVLYEEAIPESAIDQSLAAIRQADLIVIVG 180 Query: 178 TSGHVYP 184 TS V P Sbjct: 181 TSFRVSP 187 >UniRef50_C0W513 NAD-dependent deacetylase 1 n=4 Tax=Actinomycetaceae RepID=C0W513_9ACTO Length = 291 Score = 86.3 bits (212), Expect = 8e-16, Method: Compositional matrix adjust. Identities = 82/269 (30%), Positives = 122/269 (45%), Gaps = 42/269 (15%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFY--NAR 58 M R L +TGAG+S ++GI +R GL VE V + F DP + + N Sbjct: 30 MAGRRTLAVTGAGMSTDAGIPDYR---GL-GTTPVEPVDF-QQFVSDPVWYRWVWACNHA 84 Query: 59 RRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRC 118 QL +P ++P H ALA+L++A G + TQN+D LH RAG + V +HG +V C Sbjct: 85 TWQLLEP-LRPTPGHRALARLEEA-GYLTGVATQNVDRLHSRAGQSTVWELHGAYDRVVC 142 Query: 119 SQSGQVL--------------DWTGD-------VTPE------DKCH-----CCQFPAPL 146 + G+VL D+ +TPE + C C + L Sbjct: 143 LECGRVLTRAEVDQRLSALNPDYPRQSDPARVAITPEADRAAAEACSFQTVTCSKCSGLL 202 Query: 147 RPHVVWFGE-MPLGMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLE 205 +P +V+FGE +P M++ A D+ IA GTS V V +A GA V +N Sbjct: 203 KPDIVFFGESLPPAMEKAMQAAGECDVVIAAGTSLAVLTGLWIVRQAVAKGADLVVINRG 262 Query: 206 PSQVGNEFAEKYYGPASQVVPEFVEKLLK 234 P+ + G SQV+ ++L + Sbjct: 263 PTAADELATIRVEGGTSQVLAAVADRLAR 291 >UniRef50_Q12Y78 NAD-dependent deacetylase, Sir2-like n=1 Tax=Methanococcoides burtonii DSM 6242 RepID=Q12Y78_METBU Length = 245 Score = 85.9 bits (211), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 60/188 (31%), Positives = 99/188 (52%), Gaps = 10/188 (5%) Query: 7 LVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQPE 66 +VLTGAG+S SGI FR G++ + + + + + F++DP A + L+ Sbjct: 15 VVLTGAGVSTFSGIPDFRGRSGVYNKFDADLIFSIDHFNKDPAYFYAHSKSFIYDLEHR- 73 Query: 67 IQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVLD 126 QP+ H L+KL++ G ++TQNID LH++AG+ NVI +HG + C G+ Sbjct: 74 -QPSIVHSVLSKLEEK-GIIKAIITQNIDMLHQKAGSKNVIEVHGSPQEHVCLACGKKYS 131 Query: 127 W---TGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMAL---SMADIFIAIGTSG 180 + + E C + ++P +V++GEM L D I A+ S AD+ + +G++ Sbjct: 132 YEYIAELLKAEGFPLCNECGGLVKPDIVFYGEM-LRQDTIEKAIQESSKADLMLVLGSTL 190 Query: 181 HVYPAAGF 188 V PAA Sbjct: 191 VVQPAASL 198 >UniRef50_C0GF21 Silent information regulator protein Sir2 n=1 Tax=Dethiobacter alkaliphilus AHT 1 RepID=C0GF21_9FIRM Length = 247 Score = 85.9 bits (211), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 72/197 (36%), Positives = 96/197 (48%), Gaps = 18/197 (9%) Query: 7 LVLTGAGISAESGIRTFRA-ADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQ- 64 +VLTGAGIS ESGI FR+ GLWE+ ED T + F RDP +FY L+ Sbjct: 21 VVLTGAGISTESGIPDFRSPGTGLWEKEDPEDF-TIDSFQRDP---HSFYRRIHPLLKVI 76 Query: 65 PEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRC----SQ 120 + +PN H ALA L+ + G L+TQN+D LH++AG+ NV+ +HG C + Sbjct: 77 DKAEPNPGHTALADLETS-GIIKSLITQNVDGLHQKAGSKNVLEVHGSFQTGTCHDCRKK 135 Query: 121 SGQV---LDWTGDVTPEDKCHCCQFPAPLRPHVVWFG-EMPLGMDEIYMALSMADIFIAI 176 SG L T P D HC ++P V FG EMP + D + + Sbjct: 136 SGLADLNLLLTAGKDP-DCPHCGG--NTVKPDVTLFGEEMPPDFQLAHREALKCDCMLVV 192 Query: 177 GTSGHVYPAAGFVHEAK 193 G+S V P AK Sbjct: 193 GSSLQVAPVGFLPRYAK 209 >UniRef50_Q3A6W7 NAD-dependent protein deacetylases, SIR2 family n=2 Tax=Pelobacter RepID=Q3A6W7_PELCD Length = 278 Score = 85.5 bits (210), Expect = 1e-15, Method: Compositional matrix adjust. Identities = 62/193 (32%), Positives = 95/193 (49%), Gaps = 16/193 (8%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHRV--EDVATPEGFDRDPELVQAFYNARRRQLQ 63 V+ L+GAGIS +GI FR GL+ R E V + F R+P + FY R + Sbjct: 35 VVTLSGAGISTAAGIPDFRGPQGLYVTRRYDPEKVFDIDWFHREP---RYFYEFTRDFVS 91 Query: 64 QPE-IQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG 122 + I+P H LA L+ A G L+TQNID LH+ AG+ VI +HG +C G Sbjct: 92 TVKAIRPTFTHRFLAGLEKA-GGLAGLITQNIDMLHQLAGSRKVIDLHGSYRSAQCLFCG 150 Query: 123 QVLD------WTGDVTPEDK---CHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIF 173 + + W ++ K +C + L+P +V+FGEM + ++ D+ Sbjct: 151 KSYEALSYTWWERAMSTSSKPPLAYCSACNSVLKPDIVFFGEMVHAFEAAEQLIAQCDLL 210 Query: 174 IAIGTSGHVYPAA 186 + +G+S V PA+ Sbjct: 211 LVLGSSLKVTPAS 223 >UniRef50_B8LYM0 SIR2 family histone deacetylase, putative n=17 Tax=Eurotiomycetidae RepID=B8LYM0_TALSN Length = 352 Score = 85.5 bits (210), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 49/117 (41%), Positives = 67/117 (57%), Gaps = 5/117 (4%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQ 64 R+L L GAG+SA SG+ TFR A G+W +ATP F+ +P LV FY+ RR Sbjct: 50 RILALLGAGLSASSGLPTFRGAGGMWRTFDAMLLATPGAFNDNPGLVWQFYSHRRHMALN 109 Query: 65 PEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGN-TNVIH-MHGELLKVRCS 119 +PN AH ALAKL F+ ++QN+D L RA + +H +HG L +RC+ Sbjct: 110 --AKPNRAHYALAKLAQK-NKHFITLSQNVDGLSHRADHPPEQLHLLHGSLFDLRCT 163 Score = 54.7 bits (130), Expect = 3e-06, Method: Compositional matrix adjust. Identities = 37/111 (33%), Positives = 59/111 (53%), Gaps = 11/111 (9%) Query: 134 EDKCHCCQFPAPLRPHVVWFGE-MP----LGMDEIYMALSMADIFIAIGTSGHVYPAAGF 188 ED C + LRP VVWFGE +P +D+ D+ + IGTS V+PAAG+ Sbjct: 239 EDLPKCPECGGLLRPGVVWFGEGLPSHTLREIDDWIAESPQIDLMLVIGTSSKVWPAAGY 298 Query: 189 VHEAKLHGAHTVELNLEPSQV-----GNEFAEKYY-GPASQVVPEFVEKLL 233 V A+ GA +N++ + G E + ++ G AS++VPE ++ ++ Sbjct: 299 VDYAREKGARVAVVNMDRNDAPGGANGLEPGDWFFEGDASEIVPEILKSVI 349 >UniRef50_D2S8Y6 Silent information regulator protein Sir2 n=1 Tax=Geodermatophilus obscurus DSM 43160 RepID=D2S8Y6_9ACTO Length = 297 Score = 84.7 bits (208), Expect = 2e-15, Method: Compositional matrix adjust. Identities = 77/264 (29%), Positives = 117/264 (44%), Gaps = 44/264 (16%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQP 65 +VL+GAG+S +SGI +R A G H T + F RDP ++ R + P Sbjct: 39 TVVLSGAGLSTDSGIPDYRGATGSLRRHTP---MTYQTFLRDPRGRHRYWA--RSFVGWP 93 Query: 66 EIQ---PNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG 122 +I+ PNA H A+A LQ A G ++TQN+D LH+ AG +V+ +HG L + C G Sbjct: 94 QIREARPNAGHAAVADLQRA-GLVGGVITQNVDGLHQAAGARDVLELHGGLDRTVCLACG 152 Query: 123 QVLDW-----------------------TGDVTPEDK---------CHCCQFPAPLRPHV 150 V D GD D+ C C PL+P V Sbjct: 153 DVADRGQLHERLRAVNPHFGPHVDEVNPDGDAELPDELLDGFVMVDCAACGR-GPLKPDV 211 Query: 151 VWFGE-MPLG-MDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQ 208 V+FGE +P +D + + A + +G+S V FV A+ G +NL P++ Sbjct: 212 VFFGETVPRDRVDTCFAMVEQAGSLLVLGSSLTVMSGYRFVLRAEKLGIPVGLVNLGPTR 271 Query: 209 VGNEFAEKYYGPASQVVPEFVEKL 232 + + P V+P+ V ++ Sbjct: 272 GDAKVDVRVDAPLGTVLPDLVRRV 295 >UniRef50_C5DBK2 KLTH0A03300p n=1 Tax=Lachancea thermotolerans CBS 6340 RepID=C5DBK2_LACTC Length = 363 Score = 84.7 bits (208), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 49/140 (35%), Positives = 75/140 (53%), Gaps = 26/140 (18%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQ 64 ++L + G+G+SA SGI T++ G W + D+ATPE F DP LV FY+ RR + Sbjct: 20 KILCIVGSGVSASSGIATYQLQKGSWHGYTALDLATPEAFQNDPGLVWLFYSNRR--YEA 77 Query: 65 PEIQPNAAHLALAKL------------QDALG----------DRFLLVTQNIDNLHERAG 102 +PN H ALA+L A G + L+V+QN+D LH+RAG Sbjct: 78 LRAKPNEGHYALAELCRRYPSGISRRGDSASGQHPPASVNDKKKVLVVSQNVDGLHQRAG 137 Query: 103 N--TNVIHMHGELLKVRCSQ 120 + +++ +HG + +RC+Q Sbjct: 138 HPPESLVELHGSVFGLRCTQ 157 Score = 54.3 bits (129), Expect = 4e-06, Method: Compositional matrix adjust. Identities = 38/114 (33%), Positives = 58/114 (50%), Gaps = 13/114 (11%) Query: 129 GDVTPEDKCHCCQFPAPLRPHVVWFGE-MPLG-MDEIYMALSMA---DIFIAIGTSGHVY 183 GD+ +CH LRP VVW+GE +PL MDE+ + D+ + IGTSG V+ Sbjct: 242 GDLPSCPQCH----QGILRPAVVWYGESLPLDQMDEVDQFFNKGGPVDLVLVIGTSGKVW 297 Query: 184 PAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEK----YYGPASQVVPEFVEKLL 233 PA G+V AK G+ N + K + G A+Q++P+ ++ L+ Sbjct: 298 PAMGYVERAKKSGSRVAIFNRVIEDLDQVRDSKDIWGFQGDAAQLLPKALKPLI 351 >UniRef50_B3WAV7 NAD-dependent deacetylase (Regulatory protein SIR2 homolog) n=18 Tax=Lactobacillales RepID=B3WAV7_LACCB Length = 230 Score = 84.7 bits (208), Expect = 3e-15, Method: Compositional matrix adjust. Identities = 60/198 (30%), Positives = 93/198 (46%), Gaps = 18/198 (9%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPE---GFDRDPELVQAFYNAR 58 + V +TGAG+S SGI +R+ GL+ D PE D + F+ Sbjct: 10 QAKHVTFMTGAGVSTASGIPDYRSKGGLYA-----DQVDPEYALSIDNLQAHHEDFHKFV 64 Query: 59 RRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRC 118 + P +PN H +A + + G +VTQN+D L +AG +V+ HG L ++ C Sbjct: 65 VNNMYFPAAKPNVIHEKMATITNQKG---TIVTQNVDGLDRKAGAEHVVEFHGNLYRIYC 121 Query: 119 SQSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYM---ALSMADIFIA 175 + D+ + + H LRP +V +GE P+ D + A+S AD+ I Sbjct: 122 QTCHKHFDY--ETYLKSDVHAAD-GGILRPDIVLYGE-PINPDTVSAAIEAISTADLLIV 177 Query: 176 IGTSGHVYPAAGFVHEAK 193 +GTS VYP AG + A+ Sbjct: 178 VGTSFVVYPFAGLIGYAQ 195 >UniRef50_B9L4G7 NAD-dependent deacetylase 1 (Regulatory protein SIR2homolog 1) n=2 Tax=Thermomicrobia (class) RepID=B9L4G7_THERP Length = 282 Score = 84.0 bits (206), Expect = 4e-15, Method: Compositional matrix adjust. Identities = 78/217 (35%), Positives = 112/217 (51%), Gaps = 15/217 (6%) Query: 7 LVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQ-QP 65 + TGAGIS ESGI +R +GLW E+ F DPE+ + +++ RR++ Sbjct: 41 MAFTGAGISTESGIPDYRGPNGLWSR---ENPTRYRDFLNDPEVRRRYWDRRRQRYPILA 97 Query: 66 EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNT--NVIHMHGELLKVRCSQSGQ 123 +PN H+ALA+LQ A G ++VTQNID LH++AG+ V+ +HG +RC S + Sbjct: 98 GARPNVGHVALARLQ-AAGYLEIIVTQNIDGLHQKAGSPPERVVELHGTAHAIRC-LSCE 155 Query: 124 VLDWTG---DVTPEDKCHCCQFPAPL-RPHVVWFGE-MPLGMDEIYMALSMAD-IFIAIG 177 +L W D P C L + V FGE +P + E +AL+ A + + IG Sbjct: 156 LL-WPAEEFDPGPPGTIPDCPVCGGLVKEATVSFGEPVPRRILEHALALAEATPVMLVIG 214 Query: 178 TSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFA 214 TS V PAA A GA +N EP+ + E A Sbjct: 215 TSLKVVPAAHVPRRAARAGAFVAIVNDEPTPLDREAA 251 >UniRef50_C2C3V6 NAD-dependent deacetylase (Regulatory protein SIR2 family protein) n=1 Tax=Listeria grayi DSM 20601 RepID=C2C3V6_LISGR Length = 229 Score = 83.6 bits (205), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 63/217 (29%), Positives = 109/217 (50%), Gaps = 24/217 (11%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEH-RVEDVATPEGFDRDPELVQAFYNARRRQLQQ 64 +++LTGAG+S SGI +R+ +GL+ + E + + + +R+P + F ++ + Sbjct: 14 IVILTGAGVSVPSGIPDYRSENGLYADKVSPEYLLSRDCLEREPAKLHHFVISK---MYY 70 Query: 65 PEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKV---RCSQS 121 P+ PN H +A L+ ++TQNID LH++AG+ +++H HG L V RC Sbjct: 71 PDAVPNIIHQKIAALEQE--KEVTVITQNIDGLHDQAGSKSILHFHGNLQDVYCERCQLH 128 Query: 122 GQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYM-----ALSMADIFIAI 176 + D +D C LRP++V +GE G+DE + ++ AD+ + + Sbjct: 129 VPFETYQADYIHQD---CGGL---LRPNIVLYGE---GIDEGVIRASIQKINFADLILIV 179 Query: 177 GTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEF 213 GTS V P E + A V +N + Q+ +F Sbjct: 180 GTSFQVSPFCNLT-EFRNAKAEVVAINKDNLQLPFDF 215 >UniRef50_Q9Y6E7 NAD-dependent ADP-ribosyltransferase sirtuin-4 n=33 Tax=Deuterostomia RepID=SIRT4_HUMAN Length = 314 Score = 83.6 bits (205), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 78/259 (30%), Positives = 121/259 (46%), Gaps = 42/259 (16%) Query: 5 RVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEG-FDRDPELVQAFYNARRRQL 62 R+LV+TGAGIS ESGI +R+ GL+ R + G F R + Q ++ R + Sbjct: 56 RLLVMTGAGISTESGIPDYRSEKVGLYA--RTDRRPIQHGDFVRSAPIRQRYWA--RNFV 111 Query: 63 QQPEI---QPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCS 119 P+ QPN AH AL+ + LG + LVTQN+D LH +AG+ + +HG + +V C Sbjct: 112 GWPQFSSHQPNPAHWALSTWEK-LGKLYWLVTQNVDALHTKAGSRRLTELHGCMDRVLCL 170 Query: 120 QSG------------QVLD--WT---------GDV-TPEDKCH------CCQFPAPLRPH 149 G QVL+ W+ GDV E++ C Q L+P Sbjct: 171 DCGEQTPRGVLQERFQVLNPTWSAEAHGLAPDGDVFLSEEQVRSFQVPTCVQCGGHLKPD 230 Query: 150 VVWFGEM--PLGMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPS 207 VV+FG+ P +D ++ + AD + +G+S VY F+ A LN+ P+ Sbjct: 231 VVFFGDTVNPDKVDFVHKRVKEADSLLVVGSSLQVYSGYRFILTAWEKKLPIAILNIGPT 290 Query: 208 QVGNEFAEKYYGPASQVVP 226 + + K +++P Sbjct: 291 RSDDLACLKLNSRCGELLP 309 >UniRef50_A0C6J0 Chromosome undetermined scaffold_152, whole genome shotgun sequence n=1 Tax=Paramecium tetraurelia RepID=A0C6J0_PARTE Length = 449 Score = 83.2 bits (204), Expect = 7e-15, Method: Compositional matrix adjust. Identities = 67/200 (33%), Positives = 94/200 (47%), Gaps = 19/200 (9%) Query: 5 RVLVLTGAGISAESGIRTFRA-ADGLWEEHRVEDVATPEG------FDRDPELVQAFYNA 57 RV VL GAG+S +GI FR GL+ + + ++ +PE F ++PE AFY Sbjct: 211 RVCVLAGAGMSVAAGIPDFRTPGTGLYSQIQKYNLPSPESVFEIEYFKKNPE---AFYCV 267 Query: 58 RRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELLK 115 + L + +P AH L K D+ G TQNID L AG VI HG + Sbjct: 268 AKEFLLSFDAKPTLAHKFL-KFLDSRGQLLKCFTQNIDGLELDAGVSQDKVIQAHGHMRT 326 Query: 116 VRCSQSGQ---VLDWTGDVTPED--KCHCCQFPAPLRPHVVWFGE-MPLGMDEIYMALSM 169 RC + + + D+ + D +C C ++P VV+FGE +P + L Sbjct: 327 ARCIECQEEVSIKDFMSHIKKGDIHRCEKCPKKGLVKPDVVFFGEGLPGEFFYSWNCLKD 386 Query: 170 ADIFIAIGTSGHVYPAAGFV 189 AD+ I IGTS V P A V Sbjct: 387 ADLLIVIGTSLKVMPFAASV 406 >UniRef50_UPI0001742E98 NAD-dependent deacetylase n=1 Tax=candidate division TM7 single-cell isolate TM7a RepID=UPI0001742E98 Length = 126 Score = 82.4 bits (202), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 47/118 (39%), Positives = 70/118 (59%), Gaps = 9/118 (7%) Query: 11 GAGISAESGIRTFRAADGLWE-----EHRVEDVATPEGFDRDPELVQAFYNARRRQLQQP 65 GAG+S ESGI FR+A+G++ E++ + +++ PE FY+ ++ L P Sbjct: 10 GAGVSTESGIPDFRSANGVYNLKLDRNFSPEELVSHTMYEKYPE---EFYDFYKKHLVYP 66 Query: 66 EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQ 123 E +PN AH LAKL++ G +VTQNID LHE AG+ NV+ +HG + K C G+ Sbjct: 67 EAKPNFAHKYLAKLEEN-GKLTAIVTQNIDCLHEMAGSKNVLKLHGTVDKNTCVICGK 123 >UniRef50_C7TMK6 NAD-dependent protein deacetylase, SIR2 family n=12 Tax=Bacilli RepID=C7TMK6_LACRL Length = 230 Score = 82.4 bits (202), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 63/198 (31%), Positives = 94/198 (47%), Gaps = 26/198 (13%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPE---GFDRDPELVQAFYNARRRQL 62 V +TGAG+S SGI +R+ GL+ D PE D + F+ + Sbjct: 14 VTFMTGAGVSTASGIPDYRSKGGLYA-----DKVDPEYALSIDNLQAHHEDFHEFVVNNM 68 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG 122 P+ +PN H +A + + G +VTQN+D L +AG +V+ HG L ++ C Q Sbjct: 69 YYPDAKPNVIHEKMAAISNQKG---AIVTQNVDGLDRQAGAKHVVEFHGNLYRIYCQQCH 125 Query: 123 QVLDW----TGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEI---YMALSMADIFIA 175 Q D+ DV D LRP +V +GE P+ D + A++ AD+ I Sbjct: 126 QHFDYQTYLKSDVHAADG-------GILRPDIVLYGE-PINPDTVSAAINAIASADLLIV 177 Query: 176 IGTSGHVYPAAGFVHEAK 193 +GTS VYP AG + A+ Sbjct: 178 VGTSFVVYPFAGLIGYAQ 195 >UniRef50_A9BHU8 Silent information regulator protein Sir2 n=3 Tax=Bacteria RepID=A9BHU8_PETMO Length = 256 Score = 81.6 bits (200), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 57/191 (29%), Positives = 95/191 (49%), Gaps = 17/191 (8%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHRVED---VATPEGFDRDPELVQAFYNARRRQL 62 + VL+GAG+S +GI FR +G++ + +E+ + + F DP L F+ + Sbjct: 18 IAVLSGAGMSTNAGIPDFRGPNGIYTKANIENPERIFDLDYFYLDPSLFYKFHKKFLEYI 77 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRC---- 118 + E P H L +L+ G +VTQNID+LH++AG+ V +HG K C Sbjct: 78 TKAE--PTFTHKFLVQLEKE-GKLKGIVTQNIDSLHQKAGSKKVYEIHGGCWKNYCTKCK 134 Query: 119 ---SQSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIA 175 SQ + +V P KC C ++P +V+FGE + E + + +++ + Sbjct: 135 RKYSQEEILEKMNNEVVP--KCDNCG--GVIKPDIVFFGEPVKYLTESEILMKNSELVLV 190 Query: 176 IGTSGHVYPAA 186 +G+S V PAA Sbjct: 191 LGSSLAVIPAA 201 >UniRef50_C1DBX3 NAD-dependent deacetylase n=1 Tax=Laribacter hongkongensis HLHK9 RepID=NPD_LARHH Length = 248 Score = 81.6 bits (200), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 77/232 (33%), Positives = 110/232 (47%), Gaps = 11/232 (4%) Query: 6 VLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL-- 62 +LVLTGAG+S ESGI R+A G + D + F +DP AF++A R Sbjct: 18 LLVLTGAGLSTESGIPDVRSATTGQVRQPGCADALSLRFFQQDPA---AFWSAFRTLFPF 74 Query: 63 -QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 P+ H LA+L A +VTQNID LH+RAG+ +VI HG + ++ C Sbjct: 75 GTTGSACPDIGHRLLAQLA-ATDKTVTVVTQNIDGLHQRAGSPHVIEAHGSVERLVCPAC 133 Query: 122 -GQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSG 180 + D T V P CHCC L+P VV GE MD AL+ AD +G+S Sbjct: 134 LCRDHDATCQVQPVPHCHCCG--EVLKPDVVLHGEPVEAMDAALAALAEADCLWVMGSSL 191 Query: 181 HVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 P A+ + +NL+P+ + + F + P +V +F + L Sbjct: 192 EAGPVNQLPALARHWRMPSALVNLQPTALDSRFDLCLHWPIGEVCAKFRQIL 243 >UniRef50_Q9I4E1 NAD-dependent deacetylase 2 n=6 Tax=Pseudomonas aeruginosa RepID=NPD2_PSEAE Length = 256 Score = 81.6 bits (200), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 74/245 (30%), Positives = 116/245 (47%), Gaps = 22/245 (8%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLW-----EEHRVEDVATPEGFDRDPELVQAFYNARR 59 R+LV+TGAG+SA+SG+ T+R GL+ E +E + RDP L + Sbjct: 19 RILVITGAGLSADSGMPTYRGLGGLYNGRTEEGLPIEAALSGPMLRRDPALCWKYLAELG 78 Query: 60 RQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGN--TNVIHMHGELLKVR 117 + +PNA H A+A+LQ + ++L TQNID H +AG+ +I +HGEL + Sbjct: 79 KACLA--ARPNAGHEAIAELQKHKPECWVL-TQNIDGFHRQAGSPAERLIEIHGELAPLY 135 Query: 118 C----SQSGQVLD-WTGDVTPEDKCHCCQFPAPLRPHVVWFGEM--PLGMDEIYMALSMA 170 C ++SG + + G + P +C C LRP VV F EM +D +Y L Sbjct: 136 CQSCGAESGGLEEHLHGQLPP--RCAACG--GVLRPPVVLFEEMLPEEAIDTLYRELRKG 191 Query: 171 -DIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFV 229 D + +GT+ V + G T E+N + + K G A ++P+ V Sbjct: 192 FDAVLVVGTTASFPYIVEPVLRTRQAGGFTAEVNPGVTDLSERVDVKMTGRALDIMPQVV 251 Query: 230 EKLLK 234 + + Sbjct: 252 SHIYR 256 >UniRef50_UPI00019255E8 PREDICTED: similar to sirtuin n=2 Tax=Hydra magnipapillata RepID=UPI00019255E8 Length = 320 Score = 81.6 bits (200), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 68/229 (29%), Positives = 103/229 (44%), Gaps = 46/229 (20%) Query: 5 RVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQ 63 +V V+TGAG+S ESGI+ +R+ GL+ + + E F ++P Q ++ R L Sbjct: 57 KVFVITGAGVSTESGIKDYRSDKVGLYATSKQRPIEYLE-FLKNPNKRQKYW--ARNYLA 113 Query: 64 QP---EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 P QPN H L+ ++ G+ LVTQN+D+LH +AG+ V +HG +V C Sbjct: 114 WPIFSSFQPNVNHHFLSAMEKH-GNLHWLVTQNVDSLHLKAGSVRVTELHGSSARVVCLT 172 Query: 121 SGQVL--------------DWT-----------GDVTPEDK---------CHCCQFPAPL 146 G + +W GDV + CH C L Sbjct: 173 CGNKISRVELQKQLQHINSNWRSISSLNEQGPDGDVFISESDASQFKMVDCHKC--GGIL 230 Query: 147 RPHVVWFGE--MPLGMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAK 193 +P +V+FG+ P + Y LS D + IG+S VY + F+ AK Sbjct: 231 KPEIVFFGDNVSPTVKEFCYKMLSECDGVLVIGSSLQVYSSFRFIIAAK 279 >UniRef50_C3YDA2 Putative uncharacterized protein n=1 Tax=Branchiostoma floridae RepID=C3YDA2_BRAFL Length = 323 Score = 80.1 bits (196), Expect = 6e-14, Method: Compositional matrix adjust. Identities = 72/250 (28%), Positives = 110/250 (44%), Gaps = 41/250 (16%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATP---EGFDRDPELVQAFYNARRRQ 61 R+LV+TGAG+S ESG+ +R+ + V P + F +D + Q N R Sbjct: 63 RLLVITGAGLSTESGLPDYRSVKSPPRAGKDRPVIGPVMYQDFVKDTHVRQG--NWARNY 120 Query: 62 LQQPEI---QPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRC 118 + P +PN +H AL + + G LVTQN+D+LH +AG+ + +HG + C Sbjct: 121 VGWPGFSSHRPNVSHRALVQWERQ-GKLHWLVTQNVDDLHRKAGSERMTELHGSAFRAAC 179 Query: 119 SQSGQVLDWTG-----------------------DV--TPED-----KCHCCQFPAPLRP 148 V+ +G DV TPE HC + PL+P Sbjct: 180 LSCKHVVPRSGLQQVISNMNPHWEAVPFEIRPDADVALTPEQIEGFRAPHCGKCGGPLKP 239 Query: 149 HVVWFGE-MPLGMDE-IYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEP 206 +V+FGE +P + ++ L +D + G+S VY A FV A LN+ P Sbjct: 240 DMVYFGECVPKDTVQLVFEKLEESDSILVAGSSLQVYSAYRFVSAAHKQNKPVAILNIGP 299 Query: 207 SQVGNEFAEK 216 ++ N A K Sbjct: 300 TRADNLAALK 309 >UniRef50_C9M9P4 Transcriptional regulator, Sir2 family n=1 Tax=Jonquetella anthropi E3_33 E1 RepID=C9M9P4_9BACT Length = 250 Score = 79.7 bits (195), Expect = 7e-14, Method: Compositional matrix adjust. Identities = 58/186 (31%), Positives = 87/186 (46%), Gaps = 7/186 (3%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVE--DVATPEGFDRDPELVQAFYNARRRQL 62 R + TGAG+S ++G+ FR +GL+ V+ + + F DP F+ R+ L Sbjct: 19 RAVAFTGAGVSTDAGLPDFRGPNGLYRRSDVDASRLFDIDAFYEDPSYYYRFHRQLRKIL 78 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG 122 I+P H LA+ + + G LVTQN D LHE AG+ V +HG + C + G Sbjct: 79 AG--IRPTVTHRFLAQWEQS-GRLAALVTQNFDGLHEAAGSKRVFPVHGTVATNTCLRCG 135 Query: 123 QVLDWT--GDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSG 180 + + E C ++P VV+FGE + E + A AD + +GTS Sbjct: 136 RGFSAAQLDEFLAEQGVPHCPCGGVIKPDVVFFGESVKFLSESFAAAEAADFMLVLGTSL 195 Query: 181 HVYPAA 186 V PA Sbjct: 196 TVAPAC 201 >UniRef50_A3ZMQ7 Sir2 family, possible ADP ribosyltransferase n=1 Tax=Blastopirellula marina DSM 3645 RepID=A3ZMQ7_9PLAN Length = 252 Score = 79.3 bits (194), Expect = 9e-14, Method: Compositional matrix adjust. Identities = 68/214 (31%), Positives = 99/214 (46%), Gaps = 20/214 (9%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR- 60 E ++ TGAGIS ESGI FR+ G+W ++R + F + E + ++ + Sbjct: 16 ESESTVLFTGAGISTESGIPDFRSPGGVWTKYR---TIYFDEFRQSAEARREYWRQKSEA 72 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 ++ PNA H LA + A G L+TQNID LH+ AG+ V+ +HG + C Sbjct: 73 HVEFSAAAPNAGHQILAAWE-AHGVARGLITQNIDGLHQIAGSRQVLELHGTAREATCLD 131 Query: 121 SGQVLDW---------TGDVTPEDKCHCCQFPAPLRPHVVWFGEM-PLGMDEI-YMALSM 169 + TG+V P C + L+ V FG+M P + E Y S Sbjct: 132 CAARFEIDPLVVQFRETGEVPPCPNCETGR----LKHATVSFGQMLPTDVLETAYDWCSD 187 Query: 170 ADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELN 203 AD+ +AIG+S V PAA + G V LN Sbjct: 188 ADLILAIGSSLVVTPAADLPVAVRRRGGRVVILN 221 >UniRef50_D2NR35 NAD-dependent protein deacetylase n=2 Tax=Rothia mucilaginosa RepID=D2NR35_9MICC Length = 326 Score = 79.3 bits (194), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 77/250 (30%), Positives = 116/250 (46%), Gaps = 50/250 (20%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARR- 59 ++ +VLVLTGAG+S ESGI +R G +HR T + F D Q ++ AR Sbjct: 59 LKAGKVLVLTGAGVSTESGIPDYRGPGGSLHDHRP---MTYQEFRYDDAARQRYW-ARSY 114 Query: 60 ---RQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKV 116 R++++ E PN AH ALA+L+ LG ++TQN+D LH RAG++ ++ +HG+L ++ Sbjct: 115 VGWRRMRRAE--PNRAHYALAELEQ-LGAVSGVITQNVDGLHARAGSSRLLALHGDLSRI 171 Query: 117 RCSQSGQ-----VLDW----------------------TGDVTPEDK---------CHCC 140 C GQ LD GDV +D+ C C Sbjct: 172 VCLDCGQDESRESLDTRLDAANLGYLARLEDEELRVNPDGDVELDDRYIRDFQMVPCLGC 231 Query: 141 QFPAPLRPHVVWFGE-MPLGMDEIYMA-LSMADIFIAIGTSGHVYPAAGFVHEAKLHGAH 198 L+P VV+FGE +P + A L+ + +G+S V + V EA G Sbjct: 232 G-STRLKPDVVYFGESVPAERKALKDAMLAECSALLVVGSSVAVMSSYKIVLEALRAGKP 290 Query: 199 TVELNLEPSQ 208 +N P + Sbjct: 291 VAVINGGPGR 300 >UniRef50_Q885X7 NAD-dependent deacetylase 2 n=9 Tax=Pseudomonadaceae RepID=NPD2_PSESM Length = 248 Score = 79.3 bits (194), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 70/221 (31%), Positives = 110/221 (49%), Gaps = 28/221 (12%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHR-----VEDVATPEGFDRDPELVQAFYNARR 59 R+LV+TGAG+SA+SG+ T+R GL+ +E + RDPEL + Sbjct: 13 RILVITGAGLSADSGLPTYRGVGGLYNGETEDGLPIEMALSGPMLRRDPELCWKYIAELG 72 Query: 60 RQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNT--NVIHMHGELLKVR 117 + E PN AH A+A+LQ + ++L TQN+D H AG+ +I +HG+L + Sbjct: 73 KACLGGE--PNVAHYAIAQLQRIKPECWVL-TQNVDGYHRAAGSPPERLIEIHGQLSPLF 129 Query: 118 C----SQSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEM--PLGMDEIYMALSMA- 170 C +Q Q+ + P C C LRP VV F EM ++ +Y L+ Sbjct: 130 CQSCAAQDPQLSEHLQRPLP-PLCRLCG--GILRPPVVLFQEMLPERALETLYEQLATGY 186 Query: 171 DIFIAIGTSGHVYPAAGFVHE----AKLHGAHTVELNLEPS 207 D ++IGT+ +P ++HE ++ G T E+N +P+ Sbjct: 187 DAVLSIGTTAS-FP---YIHEPVIRTRVSGGFTAEINPQPT 223 >UniRef50_Q21921 NAD-dependent deacetylase SIR2 homolog n=2 Tax=Caenorhabditis RepID=SIRT1_CAEEL Length = 607 Score = 79.0 bits (193), Expect = 1e-13, Method: Compositional matrix adjust. Identities = 62/202 (30%), Positives = 94/202 (46%), Gaps = 20/202 (9%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVE--DVATPEG------FDRDPELVQAF 54 K +LVLTGAG+S GI FR+ DG++ R E D+ P F +P F Sbjct: 145 KKHILVLTGAGVSVSCGIPDFRSKDGIYARLRSEFPDLPDPTAMFDIRYFRENP---APF 201 Query: 55 YNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELL 114 YN R++ + P+ +H + +L+ + G TQNID L + G V+ HG Sbjct: 202 YNF-AREIFPGQFVPSVSHRFIKELETS-GRLLRNYTQNIDTLEHQTGIKRVVECHGSFS 259 Query: 115 KVRCSQSGQVLDWT---GDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMD---EIYMALS 168 K C++ GQ D +V HC + ++P++V+FGE LG + + Sbjct: 260 KCTCTRCGQKYDGNEIREEVLAMRVAHCKRCEGVIKPNIVFFGE-DLGREFHQHVTEDKH 318 Query: 169 MADIFIAIGTSGHVYPAAGFVH 190 D+ + IG+S V P A H Sbjct: 319 KVDLIVVIGSSLKVRPVALIPH 340 >UniRef50_A0Z2E4 NAD-dependent deacetylase n=3 Tax=unclassified Gammaproteobacteria (miscellaneous) RepID=A0Z2E4_9GAMM Length = 288 Score = 78.6 bits (192), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 72/226 (31%), Positives = 102/226 (45%), Gaps = 45/226 (19%) Query: 4 PRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQ 63 P LVLTGAGISA+SGI T+R G W +R + F + E Q ++ R + Sbjct: 16 PNWLVLTGAGISADSGIPTYRDTSGTWLRNRP---IQHQEFVQQRESRQRYWG--RSMIG 70 Query: 64 QPEIQP---NAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 P ++ NA H AL + + G L++TQN+D LH+ AG+ NVI +HG L +V C Sbjct: 71 WPNVRDARCNANHSALVDFEQS-GRSTLVITQNVDRLHQAAGSQNVIDLHGRLDRVVCLD 129 Query: 121 SG---------QVL----------------DWTGDVTPED-------KCHCCQFPAPLRP 148 G Q L D D++ E C C L+P Sbjct: 130 CGAGYERDRVQQELEELNPQHRGFEAMARPDGDADLSAEQVRDVNIWDCEVC--GGMLKP 187 Query: 149 HVVWF-GEMPL-GMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEA 192 VV+F G +P + AL+ AD + IG+S V+ F +A Sbjct: 188 DVVFFGGTIPRERVTRCQEALTAADGLLVIGSSLQVFSGFRFCRQA 233 >UniRef50_Q5GUM2 SIR2-like regulatory protein n=5 Tax=cellular organisms RepID=Q5GUM2_XANOR Length = 357 Score = 78.6 bits (192), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 76/235 (32%), Positives = 107/235 (45%), Gaps = 41/235 (17%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQ 64 R+ VLTGAG S +SGI +R G W+ R + V T + F + Q ++ R + Sbjct: 85 RLFVLTGAGCSTDSGIPDYRDLQGGWK--RPQPV-TFQAFMGELSTRQRYWA--RSLVGW 139 Query: 65 PEI---QPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRC--- 118 P QPNA H ALA L+ A G +L+TQN+D LH+ AG+ VI +HG L VRC Sbjct: 140 PRFGLAQPNATHHALAALE-ARGQLEVLLTQNVDRLHQAAGSQAVIDLHGRLDVVRCMGC 198 Query: 119 ----------------------SQSGQVLDWTGDVTPEDKCHCCQFPAP-----LRPHVV 151 ++ Q D D+ H P P L+P VV Sbjct: 199 ERRMPRTEFQLLLEQANPGWAAREAAQAPDGDADLDDVAFEHFVVPPCPVCGGVLKPDVV 258 Query: 152 WFGE-MPL-GMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNL 204 +FGE +P ++ + L AD + +G+S VY FV A +G LN+ Sbjct: 259 FFGENVPRERVERAFAHLQAADAVLVVGSSLMVYSGFRFVQTAARNGLPIAALNV 313 >UniRef50_Q07FY7 Sirtuin (Silent mating type information regulation 2 homolog) 3 (S. cerevisiae) n=3 Tax=Xenopus RepID=Q07FY7_XENTR Length = 401 Score = 78.2 bits (191), Expect = 2e-13, Method: Compositional matrix adjust. Identities = 62/202 (30%), Positives = 95/202 (47%), Gaps = 20/202 (9%) Query: 6 VLVLTGAGISAESGIRTFRA-ADGLWEEHRVEDVATPEG-FDRDPELV--QAFYNARRRQ 61 ++V+ GAGIS SGI FR GL++ + D+ PE FD + + F++ ++ Sbjct: 129 IIVMAGAGISTASGIPDFRTPGSGLYDNLQKYDIPYPEAIFDINYFVCNPNPFFHL-AKE 187 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELLKVRCS 119 L + +PN H + L D G TQNID L AG ++ +HG CS Sbjct: 188 LFPGKYKPNLVHYFIKLLHDK-GLLLRCYTQNIDGLERLAGIPVEKIVEVHGTFFSASCS 246 Query: 120 ------QSGQVLDWTGDVTPEDKCHCCQFPA-PLRPHVVWFGE-MPLGMDEIYMALSMAD 171 + + + D P CC+F A P++P +V+FGE +P + Y AD Sbjct: 247 LCYTPFPANEAKELIFDGNPP----CCKFCAGPVKPDIVFFGEDLPQTFTQAYQDFPKAD 302 Query: 172 IFIAIGTSGHVYPAAGFVHEAK 193 + I +GTS + P A V+ K Sbjct: 303 LLIIMGTSLKIEPFASLVNTVK 324 >UniRef50_Q1YSP9 NAD-dependent deacetylase n=1 Tax=gamma proteobacterium HTCC2207 RepID=Q1YSP9_9GAMM Length = 270 Score = 77.4 bits (189), Expect = 3e-13, Method: Compositional matrix adjust. Identities = 49/118 (41%), Positives = 66/118 (55%), Gaps = 5/118 (4%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 K R LVLTGAG+SAESG+ T+R G W+ + T + F + + Q F+ Sbjct: 10 SKARWLVLTGAGVSAESGVPTYRNQRGEWQR---KPPVTHQEFTGNHQARQRFWARNLVG 66 Query: 62 LQ-QPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRC 118 + +PN AH ALA L+ A G LVTQN+D LH+RAG+ VI +HG + V C Sbjct: 67 WRFMSSARPNGAHSALASLEKA-GAVSCLVTQNVDGLHQRAGSQKVIDLHGRVDSVSC 123 >UniRef50_A4VDQ9 Chromatin regulatory protein sir2 n=1 Tax=Tetrahymena thermophila SB210 RepID=A4VDQ9_TETTH Length = 279 Score = 77.4 bits (189), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 65/204 (31%), Positives = 102/204 (50%), Gaps = 25/204 (12%) Query: 5 RVLVLTGAGISAESGIRTFRAAD-GLWEE-HRVEDVATPE---GFDRDPELVQAFYNARR 59 +++VLTGAGIS +GI FR+ D GL+ + + PE D + + FY Sbjct: 32 KIIVLTGAGISTNAGIPDFRSKDTGLYARLKKSGQFSYPEQIFTIDYYQQNHKPFYEI-C 90 Query: 60 RQLQQPEIQPNAAHLALAKL--QDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELLK 115 R+ Q E +P +H + +L Q+ L +L +TQNID L +AG +I HG L K Sbjct: 91 REFVQKEYEPQQSHKFITELAKQNLL---YLNITQNIDGLELKAGLDKKYLIQAHGNLEK 147 Query: 116 VRCSQSGQ--VLDW--TGDVTPEDKCHC-----CQFPAPLRPHVVWFGE-MPLGMDEIYM 165 C + + +++ G + +D +C CQ L+P V +FGE +P +I + Sbjct: 148 SHCIECHKEDTIEYFKEGVLKSDDAVNCRKTKNCQ--GKLKPSVTFFGEKLPFYFYKIPL 205 Query: 166 ALSMADIFIAIGTSGHVYPAAGFV 189 + AD+ I +GTS V P A + Sbjct: 206 QMRFADLIIVMGTSLKVQPFASLL 229 >UniRef50_Q6C219 YALI0F11583p n=1 Tax=Yarrowia lipolytica RepID=Q6C219_YARLI Length = 320 Score = 77.4 bits (189), Expect = 4e-13, Method: Compositional matrix adjust. Identities = 69/226 (30%), Positives = 101/226 (44%), Gaps = 30/226 (13%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHRVE--------DVATPEGFDRDPELVQAFYNA 57 ++VL GAGIS GI FR+ADGL++ +E +V E FD+DP FY Sbjct: 63 IVVLCGAGISTSLGIPDFRSADGLYKSLDLESLGLSDPQEVFDLEVFDQDP---TPFYRV 119 Query: 58 RRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELLK 115 + + + + H L LQD G + TQNID+L AG + ++ HG Sbjct: 120 ASKVMMPTQALISPTHAFLKLLQDK-GKLLRIYTQNIDDLEHIAGIEESKMVQCHGAFHM 178 Query: 116 VRCSQSGQVLDWTGDVTPE------DKCHCCQFPAPLRPHVVWFGE-MP-----LGMDEI 163 C Q G + + PE C + ++P +V+FGE +P + +I Sbjct: 179 ATCRQCGAKVTCES-LRPEIVAGEIPMCRRKRCEGVIKPDIVFFGEALPDRFRHMVRSDI 237 Query: 164 YMA--LSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPS 207 M D+F+ +GTS V PA + L G V +N EPS Sbjct: 238 IMGGPTPKVDLFLCLGTSLKVSPACDIAKQVPL-GVPRVYINREPS 282 >UniRef50_C4WX51 ACYPI009170 protein n=1 Tax=Acyrthosiphon pisum RepID=C4WX51_ACYPI Length = 333 Score = 77.0 bits (188), Expect = 5e-13, Method: Compositional matrix adjust. Identities = 48/129 (37%), Positives = 72/129 (55%), Gaps = 8/129 (6%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 E ++LVLTGAGIS ESGI +R+AD GL+ + V + F ++PE+ ++ R Sbjct: 71 EHKKILVLTGAGISTESGIPDYRSADVGLYARSKNRPVIY-QQFIKNPEVRIRYW--ARN 127 Query: 61 QLQQPE---IQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVR 117 + P + PN AH L L+D ++TQN+DNLH +AG+ NV+ +HG V Sbjct: 128 YVGWPRFSSMSPNYAHKFLKNLEDK-NKIVHIITQNVDNLHTKAGSKNVLELHGTAYVVH 186 Query: 118 CSQSGQVLD 126 C + +D Sbjct: 187 CLKCDYTID 195 >UniRef50_A1U4N6 Silent information regulator protein Sir2 n=2 Tax=Marinobacter RepID=A1U4N6_MARAV Length = 298 Score = 76.3 bits (186), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 67/238 (28%), Positives = 106/238 (44%), Gaps = 42/238 (17%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 + PR+++LTGAG+S +SGI +R DG W+ + + F D Q ++ R Sbjct: 40 QHPRLMILTGAGVSTDSGIPDYRDGDGAWKR---KQPVQHKAFMEDFHTRQRYWA--RSL 94 Query: 62 LQQPEIQ---PNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRC 118 + P ++ PN +H ++ L+ L L+VTQN+D LH++AG V +HG +V C Sbjct: 95 IGWPVMRNAAPNPSHHYISDLE-LLNHSSLVVTQNVDRLHQKAGTRAVTDLHGRADEVVC 153 Query: 119 SQSG------QVLD-----------WTGDVTPEDKC------------HCCQFPAPLRPH 149 G +V D +T + P+ C + L+P Sbjct: 154 MGCGYRCPRDEVHDRCAELNPGFRKYTAETAPDGDADLDVDFSEFRPVDCPRCAGILKPD 213 Query: 150 VVWFGEMPLGMDEIYMALSM---ADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNL 204 VV+FG+ + D +Y AL + +D + IG+S VY F A LNL Sbjct: 214 VVFFGDY-VPKDRVYSALDVLKASDGLLVIGSSLMVYSGFRFCRYASEWKKPIATLNL 270 >UniRef50_A2DP91 Transcriptional regulator, Sir2 family protein n=1 Tax=Trichomonas vaginalis RepID=A2DP91_TRIVA Length = 267 Score = 75.5 bits (184), Expect = 1e-12, Method: Compositional matrix adjust. Identities = 69/245 (28%), Positives = 114/245 (46%), Gaps = 39/245 (15%) Query: 3 KPRVLVLTGAGISAESGIRTFRAAD--GLWEEHRVEDVATPEGFDR-----DPELVQAFY 55 K + ++TGAGISA + TFR++D GLW DV + D+ P++ + Sbjct: 16 KGNICIITGAGISAHV-LPTFRSSDSKGLW------DVVADKSLDKFQFYSQPDVSWKLW 68 Query: 56 NARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGN-TNVIHMHGELL 114 + R +Q + P+ AH + L G L+TQNID+LH G+ + +I +HG++ Sbjct: 69 ASIRDLQKQKFLYPSKAHRVIHYLM-KYGYIDTLLTQNIDSLHSFQGDESKIIELHGKVT 127 Query: 115 KV-RCSQSGQVLDWTGDVTPED-----------KCHCCQFPAPLRPHVVWFGEM-PLGMD 161 + C + + TP D KC C + LRP V +F ++ P + Sbjct: 128 EFGECEKCNRK-------TPVDHLKVLQSGKCPKCPVCN--SNLRPTVAFFQDLIPKALR 178 Query: 162 EIYMALS-MADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGP 220 + + D+ I IGT V P V EA GA VE+N + +++ ++ K+Y Sbjct: 179 QKATKICQTTDLLILIGTHCVVDPVVTLVAEAFQSGATVVEINPDETRISDKCDMKFYEK 238 Query: 221 ASQVV 225 A + + Sbjct: 239 ADEAL 243 >UniRef50_Q8FUC8 NAD-dependent deacetylase 1 n=11 Tax=Corynebacterium RepID=NPD1_COREF Length = 281 Score = 75.5 bits (184), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 75/254 (29%), Positives = 111/254 (43%), Gaps = 58/254 (22%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAADG--------LWEEHRVEDVATPEGFDRDPELVQ 52 +E VL +TGAG+S +SGI +R+ G ++E R + VA+ + R Sbjct: 14 LEAGSVLAVTGAGVSTDSGIPDYRSPRGSLNQGRPMTYQEFRFDPVASHRYWAR------ 67 Query: 53 AFYNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGE 112 +F R + QPN H AL +L+ A G +VTQN+D LH RAG+ N++ +HG+ Sbjct: 68 SFVGWR----VMADAQPNRTHYALVELERA-GLLSGIVTQNVDGLHRRAGSENLVALHGD 122 Query: 113 LLKVRCSQSG-----QVLDW----------------------TGDVTPEDK--------- 136 L + C Q G ++LD GDVT +D Sbjct: 123 LATIVCLQCGHREARELLDARLDHLNPGYFDSIALDPSAVNPDGDVTLDDHHVQRFTMAG 182 Query: 137 CHCCQFPAPLRPHVVWFGEMPLGMDEIYMA--LSMADIFIAIGTSGHVYPAAGFVHEAKL 194 C C L+P VV+FGE + + +A L AD + G+S V V EA+ Sbjct: 183 CARCG-SVLLKPDVVYFGEPVPSIRKTRVAQLLDGADAVVVAGSSLAVMSGYRIVIEAQR 241 Query: 195 HGAHTVELNLEPSQ 208 G +N P + Sbjct: 242 AGKPVAVINGGPGR 255 >UniRef50_Q96EB6 NAD-dependent deacetylase sirtuin-1 n=36 Tax=Euteleostomi RepID=SIRT1_HUMAN Length = 747 Score = 75.5 bits (184), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 68/227 (29%), Positives = 100/227 (44%), Gaps = 38/227 (16%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVE--DVATP------EGFDRDPELVQAFYN 56 +++VLTGAG+S GI FR+ DG++ V+ D+ P E F +DP F Sbjct: 255 KIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFA- 313 Query: 57 ARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKV 116 +++ + QP+ H +A L D G TQNID L + AG +I HG Sbjct: 314 ---KEIYPGQFQPSLCHKFIA-LSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATA 369 Query: 117 RCSQSGQVLDW---TGDVTPEDKCHCCQFPA--PL---RPHVVWFGE---------MPLG 159 C +D GD+ + C + PA PL +P +V+FGE M Sbjct: 370 SCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYD 429 Query: 160 MDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEP 206 DE+ D+ I IG+S V P A + + H + +N EP Sbjct: 430 KDEV-------DLLIVIGSSLKVRPVA-LIPSSIPHEVPQILINREP 468 >UniRef50_Q4UZX0 NAD-dependent deacetylase n=94 Tax=Bacteria RepID=NPD_XANC8 Length = 293 Score = 75.1 bits (183), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 77/258 (29%), Positives = 113/258 (43%), Gaps = 45/258 (17%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQ 64 R+ VL+GAG S +SGI +R G W+ R + V T + F + Q ++ R + Sbjct: 21 RLFVLSGAGCSTDSGIPDYRDLQGGWK--RPQPV-TFQAFMGELSTRQRYWA--RSLVGW 75 Query: 65 PEI---QPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 P +PNA H ALA L+ A G LL+TQN+D LH+ AG+ VI +HG L VRC Sbjct: 76 PRFGLARPNATHHALAALE-ARGQLELLLTQNVDRLHQAAGSQAVIDLHGRLDVVRCMGC 134 Query: 122 GQVLDWT-----------------------GDVTPED---------KCHCCQFPAPLRPH 149 Q + T GD ++ C C L+P Sbjct: 135 EQRMPRTEFQLLLERDNPGWADLEAAQAPDGDADLDNVAFDNFVVPACPACG--GVLKPD 192 Query: 150 VVWFGE-MPL-GMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPS 207 VV+FGE +P ++ + L AD + +G+S VY FV A G LN + Sbjct: 193 VVFFGENVPRERVERAFAHLQAADAVLVVGSSLMVYSGFRFVQAAARAGLPIAALNFGRT 252 Query: 208 QVGNEFAEKYYGPASQVV 225 + + + K +Q + Sbjct: 253 RADDLLSLKVEQSCAQAL 270 >UniRef50_D2A3P1 Putative uncharacterized protein GLEAN_14968 n=1 Tax=Tribolium castaneum RepID=D2A3P1_TRICA Length = 612 Score = 75.1 bits (183), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 67/242 (27%), Positives = 115/242 (47%), Gaps = 44/242 (18%) Query: 5 RVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQ 63 ++LVLTGAGIS ESGI +R+ D GL+ V E F + ++ Q ++ R + Sbjct: 45 KILVLTGAGISTESGIPDYRSEDVGLYARTNHRPVQYQE-FLKSEKVRQRYWA--RNYIG 101 Query: 64 QP---EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 P + QPN H + L+ ++G +VTQN+D+LH +AG+ NVI +HG +V C + Sbjct: 102 WPKFSQTQPNITHYIVQFLE-SVGKVGCVVTQNVDSLHFKAGSGNVIELHGTAFRVICLK 160 Query: 121 SGQVLDW-----------------------TGDV-TPEDK--------CHCCQFPAPLRP 148 G+ D GDV ++K C CQ L+P Sbjct: 161 CGKNYDRHKVQEKLIGLNPDLRETSQMIRPDGDVEISQEKVENFKPPFCDHCQ--GVLKP 218 Query: 149 HVVWFGE-MPL-GMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEP 206 + +FG+ +P +D++ ++ +D + +G+S V+ + +A +N+ P Sbjct: 219 DITFFGDNVPKERVDKVRQNVTQSDAILVLGSSLSVFSGYRIILQAVEEKKDVAIVNIGP 278 Query: 207 SQ 208 ++ Sbjct: 279 TR 280 >UniRef50_A5DW75 Putative uncharacterized protein n=1 Tax=Lodderomyces elongisporus RepID=A5DW75_LODEL Length = 379 Score = 74.7 bits (182), Expect = 2e-12, Method: Compositional matrix adjust. Identities = 48/156 (30%), Positives = 74/156 (47%), Gaps = 43/156 (27%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQ 64 +++ L GAG+ A SG+ FR + GLW+ + + D+ATP+ F DP LV FY+ RR Q Sbjct: 17 KIVALVGAGLLASSGLPVFRGSQGLWKNYNMIDLATPDAFYVDPGLVWQFYSWRRYAALQ 76 Query: 65 PEIQPNAAHLALAKL--------------QDALGD------------------------- 85 +PN HLALAKL + GD Sbjct: 77 A--KPNRGHLALAKLSKLCRSNGTSNRGESENKGDDKNIMNECKEQEQDRDRGQINSPSF 134 Query: 86 RFLLVTQNIDNLHERAGN--TNVIHMHGELLKVRCS 119 +F+ +TQN+D L R+ + ++ +HG L ++C+ Sbjct: 135 KFVTITQNVDGLSSRSEHDLQSLYEIHGSLFTLKCT 170 Score = 49.3 bits (116), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 28/80 (35%), Positives = 37/80 (46%), Gaps = 5/80 (6%) Query: 131 VTPEDKCHCCQFPAPLRPHVVWFGE-MPLG----MDEIYMALSMADIFIAIGTSGHVYPA 185 ++ +D C LRP VVWFGE +PL +D D+ + IGTSG VYPA Sbjct: 265 ISEKDLPRCPVCSELLRPGVVWFGESLPLDVITKIDNFIEEDGPVDLILVIGTSGTVYPA 324 Query: 186 AGFVHEAKLHGAHTVELNLE 205 +V K G N + Sbjct: 325 NSYVERVKYQGGKVAIFNTD 344 >UniRef50_C1SL47 NAD-dependent protein deacetylase, SIR2 family n=1 Tax=Denitrovibrio acetiphilus DSM 12809 RepID=C1SL47_9BACT Length = 274 Score = 73.9 bits (180), Expect = 4e-12, Method: Compositional matrix adjust. Identities = 63/244 (25%), Positives = 108/244 (44%), Gaps = 51/244 (20%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHRV--------EDVATPEGFDRDPELVQAFYNA 57 L LT AG+SA+SGI TFR DG W + +++A+P F AFY Sbjct: 14 CLFLTSAGMSADSGIPTFRDRDGYWRNFPIFKEKGLHPQELASPHSFRTQAHHSWAFYEW 73 Query: 58 RRRQLQQPEIQPNAAHLALAKLQDALGDRF---LLVTQNIDNLHERAG--NTNVIHMHGE 112 RRR ++ N H+ + D L + F + T N D H +G + V+ +HG Sbjct: 74 RRRNARE-----NTPHIGYEIINDMLNNYFKNAFVHTTNTDGYHLISGLDESKVMEVHGS 128 Query: 113 LLKVRC----------SQSGQV----LDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPL 158 + +++C Q+ QV LD+ ++ D C + LRP+V+ FG+ Sbjct: 129 IWRIQCMNGNGCRFMYEQNDQVPLCELDYET-MSASDMPLCPHCSSLLRPNVLMFGDWEY 187 Query: 159 ------------GMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEA-KLHGAHTVELNLE 205 +DE++ + D+ +G+S + P ++ ++ + HGA + +N + Sbjct: 188 VEHLHQYNNYRQFLDEVH----IPDLIFLVGSSSEI-PTNDYIAKSLQSHGAKVITINPD 242 Query: 206 PSQV 209 P Sbjct: 243 PDST 246 >UniRef50_C5CCZ4 NAD-dependent protein deacetylase, SIR2 family n=8 Tax=Actinomycetales RepID=C5CCZ4_MICLC Length = 314 Score = 73.6 bits (179), Expect = 6e-12, Method: Compositional matrix adjust. Identities = 77/281 (27%), Positives = 115/281 (40%), Gaps = 58/281 (20%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPE-----LVQAFY 55 ME+ R LV+TGAG+S +SGI +R +G HR T + F DP ++F Sbjct: 43 MEESRPLVITGAGVSTDSGIPDYRGPNGSLHRHR---PMTYQEFRDDPAARHRYWARSFV 99 Query: 56 NARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNT------NVIHM 109 RR + +PN AH LA+ D G ++TQN+D LH AG +I + Sbjct: 100 GWRR----MDQARPNEAHRILARWADE-GRIAGILTQNVDGLHAEAGRAAGMAEDRLIEL 154 Query: 110 HGELLKVRC-----SQSGQVLDW----------------------TGDVTPEDK------ 136 HG+L +V C ++S + LD GDV+ + Sbjct: 155 HGDLARVACLNCGATESRRDLDLRLEAANPGYLERVAIDPYAVNPDGDVSLDQHWVDEFT 214 Query: 137 ---CHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMAD--IFIAIGTSGHVYPAAGFVHE 191 C C L+P VV+FGE D +A+GTS V FV Sbjct: 215 MVGCRVCG-SVKLKPDVVYFGESVPAERRAAAEAMADDGGTVLAVGTSLAVMSGYRFVLR 273 Query: 192 AKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 A+ G T +NL P++ + ++ P + + +L Sbjct: 274 AERAGHETGLINLGPTRADAKARWRWRAPVADALAWLDARL 314 >UniRef50_A8PZF9 NAD-dependent deacetylase SIRT1, putative n=1 Tax=Brugia malayi RepID=A8PZF9_BRUMA Length = 584 Score = 73.2 bits (178), Expect = 7e-12, Method: Compositional matrix adjust. Identities = 60/201 (29%), Positives = 90/201 (44%), Gaps = 27/201 (13%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVE--DVATPEG------FDRDPELVQAFYN 56 R+LVLTGAG+S GI FR+ +G++ VE D+ P F ++P+ F Sbjct: 132 RILVLTGAGVSVSCGIPDFRSRNGVYARLHVEYPDLPDPTAMFDINYFSKNPKPFFEF-- 189 Query: 57 ARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKV 116 R+L + + H + L+D+ G TQNID L + AG ++ HG Sbjct: 190 --ARELFPGRYEASMCHYFIKALEDS-GKLLRNYTQNIDTLEQVAGIKRIVQCHGSFATA 246 Query: 117 RCSQSGQVLDWTGDVTPED-------KCHCCQFP-APLRPHVVWFGEMPLGMD---EIYM 165 C G +D + ED C C P ++P +V+FGE L D ++ Sbjct: 247 TCRNCGLKVD--SEAIREDIDSGRVAMCRVCSHPEGVMKPDIVFFGE-DLSDDFHEKMAE 303 Query: 166 ALSMADIFIAIGTSGHVYPAA 186 M D+ + IG+S V P A Sbjct: 304 DREMVDLVVVIGSSLKVQPVA 324 >UniRef50_UPI000179269F PREDICTED: similar to sirtuin n=1 Tax=Acyrthosiphon pisum RepID=UPI000179269F Length = 583 Score = 73.2 bits (178), Expect = 8e-12, Method: Compositional matrix adjust. Identities = 59/202 (29%), Positives = 93/202 (46%), Gaps = 29/202 (14%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVE--DVATPEG------FDRDPELVQAFYN 56 R++VLTGAG+S GI FR+ +G++ E D+ P+ F +DP F Sbjct: 205 RIMVLTGAGVSVSCGIPDFRSHNGVYARLATEFPDLPDPQSMFCIDYFSKDPRPFFKFA- 263 Query: 57 ARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKV 116 R++ + +P+ +H K+ + G TQNID L + G NVI HG Sbjct: 264 ---REIYPGQFKPSPSH-QFIKVLEKKGRLLRNYTQNIDTLEQVVGINNVIECHGSFATA 319 Query: 117 RCSQSGQVLDWTGDVTPE------DKCH-CCQFPAPLRPHVVWFGE-MPLGMDEIYMAL- 167 C+Q G + + P+ +C C ++P +V+FGE +P D + A+ Sbjct: 320 SCTQCGHKVSAET-IRPDVFEQRIPRCPICVNSTGIMKPDIVFFGEGLP---DSFHKAIE 375 Query: 168 ---SMADIFIAIGTSGHVYPAA 186 + D+ I IG+S V P A Sbjct: 376 DDKNNCDLLIVIGSSLKVRPVA 397 >UniRef50_Q1RPU3 Zinc finger protein (Fragment) n=1 Tax=Ciona intestinalis RepID=Q1RPU3_CIOIN Length = 737 Score = 72.0 bits (175), Expect = 2e-11, Method: Composition-based stats. Identities = 57/199 (28%), Positives = 92/199 (46%), Gaps = 22/199 (11%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVE--DVATPEG------FDRDPELVQAFYN 56 ++LVLTGAG+S GI FR+ DG++ V+ D+ P+ F DP F Sbjct: 190 KILVLTGAGVSVSCGIPDFRSRDGIYSRLSVDFPDLPNPQAMFDIHYFKHDPRPFFKF-- 247 Query: 57 ARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKV 116 +++ + +P+ AH ++ L+ G TQNID L + AG + V+ HG Sbjct: 248 --AKEIYPGQFKPSRAHRFISLLEKT-GRLLRNYTQNIDTLEQVAGISKVVQCHGSFATA 304 Query: 117 RCSQ---SGQVLDWTGDVTPEDKCHCCQFPAP----LRPHVVWFGE-MPLGMD-EIYMAL 167 C + D+ + HC + P+ ++P +V+FGE +P ++ Sbjct: 305 SCCSCDYKTNCEELRADIFNQVVPHCPRCPSDDPGVIKPDIVFFGENLPQQFHRQMTSDK 364 Query: 168 SMADIFIAIGTSGHVYPAA 186 AD+ I IG+S V P A Sbjct: 365 DDADLLIVIGSSLKVRPVA 383 >UniRef50_B0MPR9 Putative uncharacterized protein n=1 Tax=Eubacterium siraeum DSM 15702 RepID=B0MPR9_9FIRM Length = 168 Score = 71.6 bits (174), Expect = 2e-11, Method: Compositional matrix adjust. Identities = 50/152 (32%), Positives = 78/152 (51%), Gaps = 12/152 (7%) Query: 66 EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVL 125 + +PN AHL LA+L+ A G ++TQNID LH AG+ V +HG + + C + G+ Sbjct: 5 DAKPNKAHLKLAELERA-GKLTAVITQNIDGLHTAAGSKTVYELHGSVHRNYCLKCGKSY 63 Query: 126 DWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYM-----ALSMADIFIAIGTSG 180 + E H C+ ++P VV +GE +D+ + A+ D I GTS Sbjct: 64 SAEDILKSEGVPH-CECGGIIKPDVVLYGE---NLDDRTVTGALSAIERCDTLIIGGTSL 119 Query: 181 HVYPAAGFVHEAKLHGAHTVELNLEPSQVGNE 212 VYPAAGF+ +G + V +N+ + N+ Sbjct: 120 TVYPAAGFIRY--FNGNNLVLINMSSTPYDNK 149 >UniRef50_Q5CYK0 Bacterial-like Sir2 family protein (Fragment) n=3 Tax=Cryptosporidium RepID=Q5CYK0_CRYPV Length = 299 Score = 71.2 bits (173), Expect = 3e-11, Method: Compositional matrix adjust. Identities = 67/254 (26%), Positives = 106/254 (41%), Gaps = 53/254 (20%) Query: 5 RVLVLTGAGISAESGIRTFRA-ADG-----LWEEHRVEDVATPEGFDRDP-ELVQAFYNA 57 ++L +TGAG+S +SGI FR+ +DG +W +E AT F +DP + F N Sbjct: 24 KILFITGAGLSLDSGIPLFRSESDGGDGSAIWNSE-LEAWATIGSFRKDPIKWYSIFQNN 82 Query: 58 RRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELLK 115 + +PN H L+KL +R ++TQNID L ++ N+I +HG + Sbjct: 83 FKFWSSFLTAKPNEGHRVLSKLCSDFPNRIKVITQNIDGLMQQTNCPRENIIEIHGRIHY 142 Query: 116 VRC--------SQSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMP--------LG 159 +RC S +DW G ++K P ++ W L Sbjct: 143 LRCANPNCDYSSSKFSYIDWKGLFNQDNK-------IPKDFYLKWSCPSCSSPSLPLFLL 195 Query: 160 MDEIYMA------------LSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPS 207 DE Y + ++ AD+ I IGTS V +H A + +N+ P+ Sbjct: 196 FDESYTSHTFYEWEKAQTWMNEADLMIFIGTSFSVLCTDCCLHYAYRNQIPIYNVNIRPA 255 Query: 208 QV--------GNEF 213 + GN+F Sbjct: 256 PICFELYNEDGNDF 269 >UniRef50_A8NVB6 Putative uncharacterized protein n=1 Tax=Coprinopsis cinerea okayama7#130 RepID=A8NVB6_COPC7 Length = 327 Score = 70.9 bits (172), Expect = 4e-11, Method: Compositional matrix adjust. Identities = 73/298 (24%), Positives = 104/298 (34%), Gaps = 82/298 (27%) Query: 5 RVLVLTGAGISAESGIRTFRAADG--LWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 ++ +L GAG+S SGI TF G + E AT + F DP + L Sbjct: 35 QLAILAGAGLSTGSGIPTFTGQLGGVPFTYSLDEKFATAQAFKEDP--------VPHKAL 86 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNL------------------------- 97 P+ L KL++ L +TQN+DNL Sbjct: 87 GALHADPSLRSKLLRKLEEPTSSP-LFITQNVDNLSLDVLSSLKSSEEGGGGGQGKINKE 145 Query: 98 HERAGNTNVIHMHGELLKVRCSQSGQV--------------LDWTGD------------V 131 + +I MHG + + C Q V LD T V Sbjct: 146 QYQESKNRLIEMHGNIFRQECLQCRHVSTSSDTNLAFEDDSLDKTNSSSEADVNNAQVRV 205 Query: 132 TPEDKCHCCQFP--------------------APLRPHVVWFGEMPLGMDEIYMALSMAD 171 ED C P LRP V W+GE+P G+ +I L+ D Sbjct: 206 ITEDDLPRCGGPPNQKDVDSSTTTNRYYGHCKGKLRPAVTWYGEIPQGLGDIGRYLNSTD 265 Query: 172 IFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFV 229 + I +G S +PAAGF+ K G +LEPS + + G +V+P + Sbjct: 266 MLIIVGASPLAHPAAGFIRTVKERGGKVAVFHLEPSDADKDADWVFLGRCEEVLPRVL 323 >UniRef50_A0DQW0 Chromosome undetermined scaffold_6, whole genome shotgun sequence n=3 Tax=Paramecium tetraurelia RepID=A0DQW0_PARTE Length = 367 Score = 70.5 bits (171), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 58/201 (28%), Positives = 93/201 (46%), Gaps = 35/201 (17%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHR----VEDVATPEGFDRDPELVQAFYNARRRQ 61 VL+L GAG+S SG+ TFR DG W + + + V T E +P+L ++ ++ Sbjct: 123 VLILCGAGLSHASGVPTFRGKDGYWTKGKDTFECQKVLTKEFLTSNPDLCWEWHKDFQKM 182 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNL--------HERAGNTNVIH-MHGE 112 L +PNA H+A+A + L+V+QNIDN+ + G+ I+ +HG Sbjct: 183 LINK--KPNAGHIAIANYKKK-NPNTLIVSQNIDNILTSILPQKQIKHGHYESIYEIHGN 239 Query: 113 LLKVRCSQSGQVL-----------DWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLG-- 159 + +RCS+ + D T ++ P KC C A RPH+++F E Sbjct: 240 IKYMRCSKECTLEKDQLAILYDMPDLTKNLRP--KCPKCGEDA--RPHILFFDESYTNEN 295 Query: 160 --MDEIYMALSMADIFIAIGT 178 + E+ D I +GT Sbjct: 296 CRIQELQEKYETYDTIIVVGT 316 >UniRef50_UPI0001925E2D PREDICTED: similar to NAD-dependent deacetylase sirtuin-1 n=1 Tax=Hydra magnipapillata RepID=UPI0001925E2D Length = 424 Score = 70.5 bits (171), Expect = 5e-11, Method: Compositional matrix adjust. Identities = 62/208 (29%), Positives = 93/208 (44%), Gaps = 33/208 (15%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEE-HR-VEDVATPEG-FDRDPELVQAFYN-- 56 E ++VLTGAG+S GI FR+ DG++ H+ D+ P+ FD + F N Sbjct: 96 ESKNIIVLTGAGVSVSCGIPDFRSRDGIYARLHKDYPDLPDPQAMFD-----IHYFRNNP 150 Query: 57 ----ARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGE 112 +++ + P+ H ++KL D G TQNID L + AG NV+ HG Sbjct: 151 WPFFKFAKEIYPGQFTPSLCHRFISKL-DQQGKLLRNYTQNIDTLEQVAGIKNVLQCHGS 209 Query: 113 LLKVRCSQSGQVLDWTGDVTPED-------KCHCCQFPAP---LRPHVVWFGEMPLGMDE 162 C + + + ED C+ C P L+P +V+FGE D+ Sbjct: 210 CATATCMNCKYKV--SAEFIKEDIFQQKIPYCNQCSDPNSLNILKPDIVFFGES--LSDD 265 Query: 163 IYMALSM----ADIFIAIGTSGHVYPAA 186 Y ++ AD+ I IG+S V P A Sbjct: 266 FYSQINKDKDEADLLIVIGSSLKVRPVA 293 >UniRef50_Q55PY8 Putative uncharacterized protein n=2 Tax=Filobasidiella neoformans RepID=Q55PY8_CRYNE Length = 361 Score = 70.1 bits (170), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 76/290 (26%), Positives = 123/290 (42%), Gaps = 60/290 (20%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDP--ELVQAFYNARRRQL 62 + ++LTGAG+S +SGIR +R +G + + + E + P E+ + Y AR Sbjct: 42 KTVILTGAGVSVDSGIRAYRGKEGSYSNPNYKPILFHELVEDTPRGEMFRRRYWARSFLG 101 Query: 63 QQP--EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERA-----GNTN--VIHMHGEL 113 P + QPN H+ +A L LG L+TQN+DNLH +A NT ++ +HG L Sbjct: 102 YPPVRDAQPNPTHIYIAALLH-LGLAPNLITQNVDNLHPKAYRLLSPNTKPPILELHGTL 160 Query: 114 LKVRC-----------------------SQSGQVLDWTGD---VTPE------------- 134 KV C ++ + + TG P+ Sbjct: 161 AKVHCMKHRHEQSRDEYQEQISRLNPIWDEAAKEAERTGTQPRTNPDGDVDLRGANYNTF 220 Query: 135 --DKCHCCQF----PAPLRPHVVWFGEM--PLGMDEIYMALSMADIFIAIGTSGHVYPAA 186 C C+ P ++P+VV+FGE P DE + ++ A + +GTS Y A Sbjct: 221 NVPSCRICEAEGEKPTMVKPNVVFFGETIPPAVRDESFSLINSASSLLILGTSLATYSAF 280 Query: 187 GFVHEAKLHGAHTVELNLEPSQV-GNEFAEKYYGPASQVVPEFVEKLLKG 235 V A + ++ PS+ G EK A V+ +++ ++KG Sbjct: 281 RLVKLALDQKKPVLMISTGPSRADGLPGLEKMDRVAGDVLGVYLDSVVKG 330 >UniRef50_A1HU63 Silent information regulator protein Sir2 n=1 Tax=Thermosinus carboxydivorans Nor1 RepID=A1HU63_9FIRM Length = 243 Score = 70.1 bits (170), Expect = 6e-11, Method: Compositional matrix adjust. Identities = 71/201 (35%), Positives = 90/201 (44%), Gaps = 46/201 (22%) Query: 8 VLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDR-DPELVQAFYNARRRQ----- 61 VLTGAGIS SGI FR G +R + +L Q RRQ Sbjct: 22 VLTGAGISTASGIPDFR------------------GINRINADLSQLTSTFMRRQPAKAY 63 Query: 62 -LQQPEIQ------PNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELL 114 L +P IQ PNAAH+ LA+L A G L+TQNID LH RAG V +HG L Sbjct: 64 ELLRPFIQTILAASPNAAHIGLARLL-AKGVLRGLMTQNIDGLHSRAGAGVVWELHGNLY 122 Query: 115 KVRCSQSGQVLDWTGDVT--------PEDKCHCCQFPAPLRPHVVWFGE-MPLGMDEIYM 165 + C + D G + P C A LRP VV+FG+ +P Sbjct: 123 RGYCMECRTEYDMNGPLAAFLQRGQIPTSAC----CGAVLRPDVVFFGDKLPAETWRHAE 178 Query: 166 AL-SMADIFIAIGTSGHVYPA 185 L S +D+ + IG++ V PA Sbjct: 179 RLASASDLMLVIGSTLEVAPA 199 >UniRef50_Q9NTG7 NAD-dependent deacetylase sirtuin-3, mitochondrial n=38 Tax=Metazoa RepID=SIRT3_HUMAN Length = 399 Score = 70.1 bits (170), Expect = 7e-11, Method: Compositional matrix adjust. Identities = 60/201 (29%), Positives = 88/201 (43%), Gaps = 16/201 (7%) Query: 5 RVLVLTGAGISAESGIRTFRA-ADGLWEEHRVEDVATPEGFDRDPELVQAFYNAR----- 58 RV+V+ GAGIS SGI FR+ GL+ + D+ PE EL F+N + Sbjct: 139 RVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIF---ELPFFFHNPKPFFTL 195 Query: 59 RRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELLKV 116 ++L +PN H L L D G L TQNID L +G + ++ HG Sbjct: 196 AKELYPGNYKPNVTHYFLRLLHDK-GLLLRLYTQNIDGLERVSGIPASKLVEAHGTFASA 254 Query: 117 RCSQSGQVL---DWTGDVTPEDKCHCCQFPAPLRPHVVWFGE-MPLGMDEIYMALSMADI 172 C+ + D DV + C ++P +V+FGE +P + MAD+ Sbjct: 255 TCTVCQRPFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADL 314 Query: 173 FIAIGTSGHVYPAAGFVHEAK 193 + +GTS V P A + Sbjct: 315 LLILGTSLEVEPFASLTEAVR 335 >UniRef50_A7XPL0 Sirtuin 4 (Fragment) n=9 Tax=Coelomata RepID=A7XPL0_PIG Length = 201 Score = 69.7 bits (169), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 65/206 (31%), Positives = 100/206 (48%), Gaps = 42/206 (20%) Query: 8 VLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEG-FDRDPELVQAFYNARRRQLQQP 65 V+TGAGIS ESGI +R+ GL+ R + G F R + Q ++ R + P Sbjct: 1 VMTGAGISTESGIPDYRSEKVGLYA--RTDRRPIQHGDFVRSAPIRQRYWA--RNFVGWP 56 Query: 66 EI---QPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG 122 + QPN AH AL+ + LG + LVTQN+D LH +AG+ + +HG + +V C G Sbjct: 57 QFSSHQPNPAHWALSNWE-RLGKLYWLVTQNVDALHTKAGSQRLTELHGCMHRVLCLDCG 115 Query: 123 ------------QVLD--WT---------GDV-TPEDKCHCCQFPA------PLRPHVVW 152 +VL+ W+ GDV E++ Q P+ PL+P VV+ Sbjct: 116 EQTPRRVLQERFEVLNPTWSAEAHGLAPDGDVFLTEEQVQSFQVPSCSRCGGPLKPDVVF 175 Query: 153 FGEM--PLGMDEIYMALSMADIFIAI 176 FG+ P +D ++ + AD + + Sbjct: 176 FGDTVNPNTVDFVHKRVKEADSLLVV 201 >UniRef50_D1MN70 Protein F46G10.7c, confirmed by transcript evidence n=7 Tax=Caenorhabditis RepID=D1MN70_CAEEL Length = 294 Score = 69.7 bits (169), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 70/266 (26%), Positives = 119/266 (44%), Gaps = 49/266 (18%) Query: 5 RVLVLTGAGISAES--GIRTFRAAD-GLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 ++LV++GAGIS ES GI +R+ D GL+ + + + + R Q +++ R Sbjct: 34 KLLVISGAGISTESVPGIPDYRSKDVGLYARIAHKPIYF-QDYMRSNRCRQRYWS--RNF 90 Query: 62 LQQPEI---QPNAAHLALAKLQDALGDRF-LLVTQNIDNLHERAGNTNVIHMHGELLKVR 117 L P PN H AL+K + + DRF L+TQN+D LH +AG+ V +HG L+V+ Sbjct: 91 LAWPRFGQAAPNINHYALSKWEAS--DRFQWLITQNVDGLHLKAGSKMVTELHGSALQVK 148 Query: 118 CSQSGQV---------LDWT-----------GDVTPEDKC-------------HCCQFPA 144 C+ + LD+ G++ P+ C Sbjct: 149 CTTCDYIESRQTYQDRLDYANPGFKEEHVAPGELAPDGDIILPLGTEKGFQIPECPSCGG 208 Query: 145 PLRPHVVWFGEMPLGMDEI---YMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVE 201 ++ V +FGE + MD++ Y ++ D +++GTS V F+H A + Sbjct: 209 LMKTDVTFFGE-NVNMDKVNFCYEKVNECDGILSLGTSLAVLSGFRFIHHANMKKKPIFI 267 Query: 202 LNLEPSQVGNEFAEKYYGPASQVVPE 227 +N+ P++ + K S V+ E Sbjct: 268 VNIGPTRADHMATMKLDYKISDVLKE 293 >UniRef50_C7MA66 NAD-dependent protein deacetylase, SIR2 family n=1 Tax=Brachybacterium faecium DSM 4810 RepID=C7MA66_BRAFD Length = 339 Score = 69.7 bits (169), Expect = 8e-11, Method: Compositional matrix adjust. Identities = 70/264 (26%), Positives = 103/264 (39%), Gaps = 68/264 (25%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYN---ARRRQL 62 V VLTGAG+S SG+ +R D + R P Q F ARRR Sbjct: 76 VAVLTGAGMSTGSGLPDYRGRDAV---------------PRSPMTYQEFMGHDLARRRYW 120 Query: 63 QQPEI--------QPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELL 114 + + +P AH LA L D L ++TQN+D LH+ AG+ VI +HG L Sbjct: 121 ARSTVGWEQFRTARPGRAHRLLAALGDTLFSPTAVITQNVDGLHQAAGSDPVIDLHGRLD 180 Query: 115 KVRC-------------------------------SQSGQVLDWTGDVTPEDKCHCCQFP 143 +VRC + + Q D +V D+ ++P Sbjct: 181 RVRCQHCDALSSRRLLHERMLMMNPELAARLPELAADAAQAPDGDAEV---DRTSTFRYP 237 Query: 144 ------APLRPHVVWFGEMPLG--MDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLH 195 L+P VV+FGE + + AL A + +G+S V FV A Sbjct: 238 PCPLCGGILKPDVVFFGESARREVVTAAFTALEAAQALLVLGSSLTVQSGLRFVRAAVRT 297 Query: 196 GAHTVELNLEPSQVGNEFAEKYYG 219 G V +N P++ + + +G Sbjct: 298 GTPIVIVNDGPTRADSLATLRVHG 321 >UniRef50_C5M5U2 NAD-dependent histone deacetylase SIR2 n=2 Tax=Candida RepID=C5M5U2_CANTT Length = 499 Score = 69.7 bits (169), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 70/245 (28%), Positives = 105/245 (42%), Gaps = 30/245 (12%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATP------EGFDRDPELVQAFYNAR 58 +++V+TGAGIS GI FR+ GL+ + ++ P E F +DP L FY Sbjct: 222 KIVVITGAGISTSLGIPDFRSFQGLYTQLSKLQLSDPQKVFDMETFKKDPSL---FYTIA 278 Query: 59 RRQLQQPEIQPNAAHLALAKLQDALGDRFLL-VTQNIDNLHERAGNT--NVIHMHGELLK 115 L PE + H L L+D ++ L TQNIDNL +RAG + +I HG Sbjct: 279 HMVL-PPEGKFALFHSFLKLLEDK--NKLLRNYTQNIDNLEQRAGISPEKLIQCHGSFSH 335 Query: 116 VRCSQSGQVLDWTGDVTPEDK-----CHCC--------QFPAPLRPHVVWFGE-MPLGMD 161 +C G + K C C ++P + +FGE +P Sbjct: 336 AKCITCGAIFKGEKIFNHIKKLQVPRCSKCWEDVQEAELIYGVIKPTITFFGEDLPERFH 395 Query: 162 EIYMA-LSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGP 220 ++ L AD+ I GTS +V P AG V + H + + +G+ F + G Sbjct: 396 RLHSKDLKNADMVIVSGTSLNVNPVAGLVEKVPSHVPKILINKDQIDDMGSLFNLRLIGL 455 Query: 221 ASQVV 225 +VV Sbjct: 456 CDEVV 460 >UniRef50_A7H2V7 NAD-dependent deacetylase n=1 Tax=Campylobacter jejuni subsp. doylei 269.97 RepID=A7H2V7_CAMJD Length = 177 Score = 69.3 bits (168), Expect = 9e-11, Method: Compositional matrix adjust. Identities = 32/69 (46%), Positives = 48/69 (69%), Gaps = 2/69 (2%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQ 64 + ++L+GAG+SA SG +TF+ DGL EE+ V +V + GF ++P+ V FY+ RR QLQ Sbjct: 3 QAMLLSGAGLSAPSGFKTFKDNDGLLEEYDVMEVCSATGFRKNPKKVLDFYDTRRAQLQN 62 Query: 65 PEIQPNAAH 73 ++PN AH Sbjct: 63 --VKPNHAH 69 >UniRef50_D2VK77 Putative uncharacterized protein n=1 Tax=Naegleria gruberi RepID=D2VK77_NAEGR Length = 469 Score = 69.3 bits (168), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 65/230 (28%), Positives = 101/230 (43%), Gaps = 34/230 (14%) Query: 5 RVLVLTGAGISAESGIRTFRAA-----DGLWE-----EHRVEDVATPEGFDRDPELVQAF 54 ++L LTGAGIS ESGI FR + +WE E +++ + + D + AF Sbjct: 214 KILGLTGAGISVESGISAFRNSGNSQLQNIWEKWNQDEMTYQNILSKKKIRDDYFEMHAF 273 Query: 55 YNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGE 112 + Q+ + E PN +H A+L++ G ++TQNID +H++AG + VI +HG Sbjct: 274 L---KEQISKAE--PNGSHHLFAQLKEK-GKLLKVITQNIDGMHQKAGLSDDKVIEIHGS 327 Query: 113 LLKVRCSQS-----------GQVLDWT--GDVTPEDKCHCCQFPAPLRPHVVWFGE--MP 157 V C++ QV D G P D+ C+ L+P+ + FGE Sbjct: 328 SRGVVCTKCRTLVEDPEKIYSQVKDCVLEGKSLP-DELVTCKCGGVLKPNTISFGEELQD 386 Query: 158 LGMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPS 207 + E D+ I +GT V P V +NLE + Sbjct: 387 SKLIEARQQCRECDLMIIMGTRLLVSPVNQLPKLVAARNVPVVIINLEST 436 >UniRef50_A4A980 NAD-dependent deacetylase n=6 Tax=Gammaproteobacteria RepID=A4A980_9GAMM Length = 241 Score = 69.3 bits (168), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 50/147 (34%), Positives = 69/147 (46%), Gaps = 15/147 (10%) Query: 6 VLVLTGAGISAESGIRTFRAADGLW----EEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 L +TGAG+SAESGI TFR DG W + +++AT ++ DP +Y R Sbjct: 3 TLYITGAGVSAESGIPTFRGEDGFWTIGSRNYTPQEMATRAMYENDPLQFLRWYYQRFAS 62 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 + PNA H LA L+TQNID L +AGN + I +HG L ++ Sbjct: 63 YRHH--GPNAVHRWLADKN--------LITQNIDGLDGKAGNKDYIAIHGRLDQMTIFHD 112 Query: 122 GQVLDW-TGDVTPEDKCHCCQFPAPLR 147 + D T TP D+ + LR Sbjct: 113 QNLADQVTALYTPWDEVEENRLDDSLR 139 >UniRef50_A4QUX8 Putative uncharacterized protein n=1 Tax=Magnaporthe grisea RepID=A4QUX8_MAGGR Length = 460 Score = 69.3 bits (168), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 65/201 (32%), Positives = 94/201 (46%), Gaps = 26/201 (12%) Query: 5 RVLVLTGAGISAESGIRTFRA-ADGLWEEHRVEDVATPEG-----FDRD-PELVQAFYNA 57 R+ V+TGAGIS +GI FR+ GL+ + PE F RD PE FY Sbjct: 41 RITVMTGAGISTAAGIPDFRSPGTGLYSNLERLKLPEPEAVFDISFFRDRPE---PFY-V 96 Query: 58 RRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELLK 115 ++L + QP +H +A L G + TQNID L +AG VI HG Sbjct: 97 LAKELYPGKFQPTISHAFIALLSKK-GLLQMNFTQNIDCLERQAGVPGEKVIEAHGSFAT 155 Query: 116 VRCSQSGQ-------VLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGE-MPLGMDEIYMAL 167 C + + +L ++ P +C C ++P++V+FGE +P E + Sbjct: 156 QSCIECKELFPDDEMLLHVEKEIVP--RCASCN--GLVKPNIVFFGEPLPRTFSEKCHLV 211 Query: 168 SMADIFIAIGTSGHVYPAAGF 188 + +D+ I IGTS VYP AG Sbjct: 212 AESDLAIIIGTSLTVYPFAGL 232 >UniRef50_C4Q5J6 Chromatin regulatory protein sir2, putative n=2 Tax=Schistosoma RepID=C4Q5J6_SCHMA Length = 618 Score = 68.9 bits (167), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 68/248 (27%), Positives = 111/248 (44%), Gaps = 35/248 (14%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHRVE--DVATPEG------FDRDPELVQAFYNA 57 +LV+TGAGIS GI FR+ DG++ + D+++P+ F R+P + F A Sbjct: 157 ILVITGAGISVSCGIPDFRSRDGIYARLSRDYPDLSSPQAMFDMSYFKRNP--IPFFKFA 214 Query: 58 RRRQLQQPEIQPNAAHLALAKLQDALGDRFLL-VTQNIDNLHERAGNTNVIHMHGELLKV 116 ++L + P+ H +A L+ D+ L TQNID L + AG T +I HG Sbjct: 215 --KELFPGQFSPSITHRMIALLESK--DKLLRNYTQNIDTLEQAAGITRLIQCHGSFASA 270 Query: 117 RCSQSGQVLDWTGDVTPE-------DKCHCCQFPAPLRPHVVWFGEMPLGM-----DEIY 164 C+ L + D E +C + L+P +V+FGE G+ D + Sbjct: 271 TCTNCK--LKVSSDFIKEAIFTQSIPRCTNSSY-GVLKPDIVFFGE---GLSNEFHDSLS 324 Query: 165 MALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQV 224 + D+ + IG+S V P + + A + +N EP ++F + G + Sbjct: 325 NDIKQTDLVLVIGSSLKVRPVS-HIPNAVPRQVPQILINREPLS-NHDFDVELLGDCDVI 382 Query: 225 VPEFVEKL 232 V E +L Sbjct: 383 VSELCHRL 390 >UniRef50_D1VJM1 Silent information regulator protein Sir2 n=1 Tax=Frankia sp. EuI1c RepID=D1VJM1_9ACTO Length = 341 Score = 68.9 bits (167), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 48/119 (40%), Positives = 63/119 (52%), Gaps = 8/119 (6%) Query: 9 LTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFY---NARRRQLQQP 65 LTGAGIS ESGI +R G R T + F DPE + ++ +A R + Sbjct: 52 LTGAGISTESGIPDYRGPSG--APRRNHTPMTYQQFTGDPEFRRRYWARSHAGWRHIAA- 108 Query: 66 EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQV 124 PNA H A+A L+ A G +VTQN+D LH+ G +VI +HG L +V CS G V Sbjct: 109 -APPNAGHRAVAALERA-GLLAGIVTQNVDGLHQAGGARDVIELHGNLARVLCSDCGDV 165 >UniRef50_Q882K4 NAD-dependent deacetylase 3 n=7 Tax=Pseudomonas RepID=NPD3_PSESM Length = 281 Score = 68.9 bits (167), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 74/268 (27%), Positives = 108/268 (40%), Gaps = 40/268 (14%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 M + LV+TGAGIS SGI +R DG+ R + F +P Q ++ R Sbjct: 17 MAEKSFLVVTGAGISTASGIPDYRDKDGV---RRGAQPMMYQEFVGNPAARQRYWA--RA 71 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFL--LVTQNIDNLHERAGNTNVIHMHGELLKVRC 118 L P I + A+ A L + + L+TQN+D LH +AG+ +VI +HG L +V C Sbjct: 72 MLGWPRISASQANAAHRALAALQAENLIKGLITQNVDALHTQAGSQDVIELHGSLHRVLC 131 Query: 119 SQSGQVLDWT-------------GDV---------TPEDKCHCCQFPAP---------LR 147 Q D T DV T D + F P L+ Sbjct: 132 LDCQQRSDRTAIQEQMLAHNLYLADVHATQAPDGDTLLDPAYEAGFKVPECPHCQGKRLK 191 Query: 148 PHVVWFGEMPLGMDEIYMALSM--ADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLE 205 P VV+FGE LS+ A+ + +GTS + A G + +N Sbjct: 192 PDVVFFGENVASHTAARATLSVEQAEGLLVVGTSLMAWSAFRLCKAMAEQGKPVIAINHG 251 Query: 206 PSQVGNEFAEKYYGPASQVVPEFVEKLL 233 ++ K P QV+P E+L+ Sbjct: 252 KTRADELLRMKIEAPCEQVLPWLAEQLI 279 >UniRef50_D2VCI1 Silent information regulator family protein n=2 Tax=Naegleria gruberi RepID=D2VCI1_NAEGR Length = 452 Score = 68.9 bits (167), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 65/248 (26%), Positives = 110/248 (44%), Gaps = 50/248 (20%) Query: 6 VLVLTGAGISAESGIRTFRAADGLW--EEHRVEDVATPEGFDRDPELVQAFYNARRRQLQ 63 +++ TGAGIS +GIR +R+ +G+W +E V+ VA ++ + Sbjct: 106 IVLYTGAGISRAAGIRDYRSPNGVWTMKEKGVKTVA--------------------KKDE 145 Query: 64 QPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGE--------- 112 I P H+A++ L +A G + +QN+D LH ++G N+ +HG Sbjct: 146 SKIIFPTRTHMAISTLYNA-GKIQYVTSQNVDGLHVKSGIPRKNMSELHGNTNVEICHKC 204 Query: 113 ----LLKVRCSQSGQVLD-WTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMA- 166 + RC + V D TG C C+ + L ++ F E L D++ A Sbjct: 205 NIEYVRNFRCRNNKNVHDHRTGRF-----CEKCK--SELEDTIINFNEN-LPTDQLERAE 256 Query: 167 --LSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQV 224 S AD+ I +GTS V PA K +G V +NL+ + + + + A +V Sbjct: 257 ENASKADLAIVVGTSMRVNPACSLPQMCKENGGKLVIINLQLTPKDKKADLRIFAEADKV 316 Query: 225 VPEFVEKL 232 + ++KL Sbjct: 317 IDTVMKKL 324 >UniRef50_Q54LF0 Ankyrin repeat-containing protein n=1 Tax=Dictyostelium discoideum RepID=Q54LF0_DICDI Length = 778 Score = 68.6 bits (166), Expect = 2e-10, Method: Composition-based stats. Identities = 65/217 (29%), Positives = 94/217 (43%), Gaps = 32/217 (14%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 E V+VL+GAGISA +GI +R DGL +++ + E ++ P++ FY A R Sbjct: 487 EFKNVIVLSGAGISANAGIPPYRTKDGLLAKNKQFSFSM-EILEKHPDV---FYQAIRDH 542 Query: 62 LQ---------------QPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTN- 105 I+ +H + L + G TQN+D L ER G Sbjct: 543 FYPIIKASNDNDRDDGISAGIKSTKSHYFINDLNEKYGCLLRNYTQNVDPLQERTGTPTD 602 Query: 106 -VIHMHGELLKVRCSQ-SGQVLDWTGDVTPE---DKCHCCQFPA---PLRPHVVWFGEMP 157 +IH HG + C+ Q D + + E C P +RP+VV+FGE P Sbjct: 603 KIIHAHGSFDQWYCTVCQKQYTDKSDRIWREIGRGGLPFCTEPECRHVIRPNVVFFGE-P 661 Query: 158 LGMD---EIYMALSMADIFIAIGTSGHVYPAAGFVHE 191 L D AD+ I +GTS VYP A V++ Sbjct: 662 LSQDFRVNTITDFRKADLLIVMGTSLIVYPFASLVND 698 >UniRef50_D0R2Y5 NAD-dependent deacetylase n=16 Tax=Lactobacillus RepID=D0R2Y5_LACJF Length = 237 Score = 68.6 bits (166), Expect = 2e-10, Method: Compositional matrix adjust. Identities = 52/194 (26%), Positives = 91/194 (46%), Gaps = 31/194 (15%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQA----------FY 55 + LTGAG+S S I +R+ +G++ G PE + + F+ Sbjct: 20 ITYLTGAGVSTPSHIPDYRSKNGIYN-----------GISESPEQILSEATLFHQPAKFH 68 Query: 56 NARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLK 115 + + P+ +PN H +A + G L+TQN+D L ++AGN +VI HG+L Sbjct: 69 HLVMENMYFPDAKPNIIHQKIAASCNKNG---TLITQNVDGLDKKAGNKHVIEFHGDLYN 125 Query: 116 VRCSQSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLG---MDEIYMALSMADI 172 + C++ + + + D + H + +RP +V +GE P+ + + + +D+ Sbjct: 126 IYCTKCHEKISY--DNYKKSYLH-EKDQGIIRPGIVLYGE-PINEKILTKSVKKIHDSDL 181 Query: 173 FIAIGTSGHVYPAA 186 I GTS VYP A Sbjct: 182 VIIAGTSFVVYPFA 195 >UniRef50_UPI000051AA14 PREDICTED: similar to NAD-dependent deacetylase sirtuin-1 (hSIRT1) (hSIR2) (SIR2-like protein 1) n=1 Tax=Apis mellifera RepID=UPI000051AA14 Length = 868 Score = 68.6 bits (166), Expect = 2e-10, Method: Composition-based stats. Identities = 59/198 (29%), Positives = 91/198 (45%), Gaps = 26/198 (13%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEE--HRVEDVATPEG------FDRDPELVQAFYN 56 R++VLTGAG+S GI FR+ DG++ D+ P+ F +DP + FY Sbjct: 205 RIIVLTGAGVSVSCGIPDFRSRDGIYSRLAQDFPDLPDPQAMFDINYFSQDP---RPFYK 261 Query: 57 ARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLK- 115 R++ + +P+ H K+ D +QNID L + AG NVI HG Sbjct: 262 F-AREIYPGQFKPSPCH-RFIKMLDKQKKLLRNYSQNIDTLEQVAGIENVIECHGSFATA 319 Query: 116 --VRCSQSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGE-MPLGMDEIYMALSM--- 169 RC + D D+ + C + ++P +V+FGE +P D + A++ Sbjct: 320 SCTRCKYQVKADDIREDIFSQRIPLCPK--CIMKPDIVFFGEGLP---DAFHDAMAKDKD 374 Query: 170 -ADIFIAIGTSGHVYPAA 186 D+ I IG+S V P A Sbjct: 375 ECDLLIVIGSSLKVRPVA 392 >UniRef50_B3S4A5 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens RepID=B3S4A5_TRIAD Length = 295 Score = 67.8 bits (164), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 58/228 (25%), Positives = 101/228 (44%), Gaps = 41/228 (17%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEGFDRDPELVQAFYNARR 59 ++ ++L+LTGAG+S SGI +R+ GL+ + + + D + + Sbjct: 31 LKSKKLLILTGAGVSTASGIPDYRSKGVGLYARSNQRPMQYSDFLENDENRKRYWSRNFT 90 Query: 60 RQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCS 119 + ++PN H +AKL+ L +VTQN+D LH+RAG++ + +HG + +V C Sbjct: 91 GWSRFSSVKPNLTHNFIAKLEQ-LKLLHWVVTQNVDGLHQRAGSSRLTELHGTMHEVICL 149 Query: 120 QSGQVL--------------DWT---------GDVTPED---------KCHCCQFPAPLR 147 Q +++ +WT DV + KC C L+ Sbjct: 150 QCQKIILRREFQDILSKLNPNWTVKSIQTAPDADVFIAENEVMKFNLAKCEC---GGVLK 206 Query: 148 PHVVWFGEMPLGMD---EIYMALSMADIFIAIGTSGHVYPAAGFVHEA 192 P+VV+FG + D E+ + AD + +G+S Y A + A Sbjct: 207 PNVVFFGG-SISKDINEEVRQHVDEADSILVVGSSLQTYSAYRIISRA 253 >UniRef50_C8WXB4 Silent information regulator protein Sir2 n=2 Tax=Alicyclobacillus acidocaldarius RepID=C8WXB4_ALIAD Length = 237 Score = 67.8 bits (164), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 58/186 (31%), Positives = 87/186 (46%), Gaps = 20/186 (10%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 K ++ +TGAGIS ESG+ T D + + + P + P ++AF+ R Sbjct: 23 KSHLVAITGAGISVESGLPT---VDDMVAGVPLRSLFQPNIWREQP--LEAFHAFRVIAR 77 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG 122 + +PN AHLALA+ + ++TQNID LH AG+T VI +HG L ++RC G Sbjct: 78 EWQRKRPNRAHLALAQAE------IPIITQNIDGLHRAAGSTRVIELHGNLRELRCDACG 131 Query: 123 QV----LDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGT 178 + L W + KC C LRP V GE + ++ A + +GT Sbjct: 132 GIFQSELAWREQLP---KCPTCG--ELLRPGFVLEGEEVRHIARALDWVTEARGLLVVGT 186 Query: 179 SGHVYP 184 + P Sbjct: 187 ELQMTP 192 >UniRef50_D2Q1M5 Silent information regulator protein Sir2 n=7 Tax=Actinomycetales RepID=D2Q1M5_9ACTO Length = 294 Score = 67.8 bits (164), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 67/229 (29%), Positives = 98/229 (42%), Gaps = 38/229 (16%) Query: 9 LTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQPEIQ 68 L+GAGIS ESGI +R A G H G + A + R + + + Sbjct: 40 LSGAGISTESGIPDYRGASGSLRTHTPMTYGDFVGSEAGRRRYWARSHLGWRTIARAD-- 97 Query: 69 PNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQV---- 124 PNA H A+A LQ A G ++TQN+D LH+ AG +VI +HG L +V C + Sbjct: 98 PNAGHRAVATLQ-ARGYLTAVITQNVDGLHQSAGARDVIELHGNLDRVICLDCHETSPRE 156 Query: 125 -------------------LDWTGDVTPEDK---------CHCCQFPAPLRPHVVWFGE- 155 ++ GDV D+ C C P L+P VV+FGE Sbjct: 157 DLDRRLRAANPAFEGRALRINPDGDVELPDEAVEGFRLVPCRRCGSPL-LKPDVVFFGEN 215 Query: 156 MPL-GMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELN 203 +P ++ Y + A+ + +G+S V FV A G + +N Sbjct: 216 VPKPRVERCYRLIDEAEAMLVLGSSLTVMSGFRFVRYAAKAGKPVLIIN 264 >UniRef50_C7TJ15 Silent information regulator protein Sir2 n=4 Tax=Lactobacillus rhamnosus RepID=C7TJ15_LACRL Length = 241 Score = 67.8 bits (164), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 61/195 (31%), Positives = 86/195 (44%), Gaps = 23/195 (11%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEE-HR----VEDVATPEGFDRDPELVQAFYNARR 59 +++ TGAGIS ESGI D + ++ H+ + PE DP FY R Sbjct: 19 QIVAFTGAGISTESGIPDLNGIDQILKKSHKFAGDIFRFLDPEEASADPS---GFYQLYR 75 Query: 60 RQLQQPEIQPNAAHLALAKLQDALGDRFL-LVTQNIDNLHERAGNTNVIHMHGELLKVRC 118 + QPE PN AH AL +L+ A ++ L +VT N+D LH+ AG +V G++ C Sbjct: 76 QTFCQPEALPNRAHQALVQLEQA--NKLLGVVTMNVDYLHQTAGTRHVAEYWGDVRHNHC 133 Query: 119 SQSGQVLDW----TGDVTPEDKCHCCQFPA-PLRPHVVWFGEMPLGMDEIYMALSMADIF 173 + DW T V C P LR + E+ G L+ AD+ Sbjct: 134 TICHHSYDWQKPSTSTVPTCPNCGGLILPDFVLRRLATYPDEIKYGQ----QMLAQADLL 189 Query: 174 IAIGTSGHVYPAAGF 188 + IGT PA F Sbjct: 190 LIIGTR---RPATSF 201 >UniRef50_D1ZEY9 Whole genome shotgun sequence assembly, scaffold_24 n=1 Tax=Sordaria macrospora RepID=D1ZEY9_SORMA Length = 318 Score = 67.4 bits (163), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 71/243 (29%), Positives = 105/243 (43%), Gaps = 50/243 (20%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEG-------------FDRDPE-- 49 R+L + GAG+SA SG+ A E ++ PE Sbjct: 20 RILAICGAGLSAASGLPPSAAPADYGETMKLRTWRLRRRLLRIRGWCGYFMLIRTKPEYA 79 Query: 50 ---LVQAFYNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NT 104 L + +RR + +++PN+ H ALA L A + FL +TQN+DNL RAG ++ Sbjct: 80 TQVLTKETLTTQRRHMAL-QVKPNSGHHALAALARAKPN-FLCLTQNVDNLSPRAGHPSS 137 Query: 105 NVIHMHGELLKVRCSQSGQVLD-----WTGDVTPEDKCHCCQFPAP-------------- 145 + +HG L ++CS + +D G + D H AP Sbjct: 138 QLRTLHGSLFTLKCSSATSSVDPPDPSQPGKIPLLDPSHPLPTIAPSQLPQCPRCKESGK 197 Query: 146 ---LRPHVVWFGE-----MPLGMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGA 197 LRP VVWFGE M +D+ ++ DI + +GTS VYPAAG+ A+ G Sbjct: 198 QSLLRPGVVWFGESLDAQMLKEVDD-WIDQGPIDIVLVVGTSSVVYPAAGYAERARTKGV 256 Query: 198 HTV 200 +V Sbjct: 257 TSV 259 >UniRef50_B9GC62 Putative uncharacterized protein n=1 Tax=Oryza sativa Japonica Group RepID=B9GC62_ORYSJ Length = 446 Score = 67.4 bits (163), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 48/136 (35%), Positives = 69/136 (50%), Gaps = 25/136 (18%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAF---YNAR 58 + +++VLTGAG+S ESGI +R+ +G + GF P Q F AR Sbjct: 110 QSKKLMVLTGAGMSTESGIPDYRSPNGAYS----------SGF--KPLTHQEFVRSIRAR 157 Query: 59 RRQLQQP--------EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMH 110 RR + QPN+AH ALA L+ +G +VTQN+D LH RAG + + +H Sbjct: 158 RRYWARSYAGWRRFRRAQPNSAHYALASLE-RIGRVHSMVTQNVDRLHHRAG-SKPVELH 215 Query: 111 GELLKVRCSQSGQVLD 126 G + +V C G +D Sbjct: 216 GSVYEVACLDCGTSID 231 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_D0KGP3 Silent information regulator protein Sir2 n=11 T... 339 4e-92 UniRef50_Q9CM50 NAD-dependent deacetylase n=5 Tax=Proteobacteria... 322 4e-87 UniRef50_B8KDE3 NAD-dependent deacetylase n=4 Tax=Gammaproteobac... 312 5e-84 UniRef50_D2LLI1 Silent information regulator protein Sir2 n=3 Ta... 307 2e-82 UniRef50_A0LP75 Silent information regulator protein Sir2 n=3 Ta... 303 3e-81 UniRef50_Q6MJJ2 NAD-dependent deacetylase n=8 Tax=Proteobacteria... 298 1e-79 UniRef50_C8S918 Silent information regulator protein Sir2 n=1 Ta... 294 2e-78 UniRef50_O30124 NAD-dependent deacetylase 2 n=18 Tax=cellular or... 292 6e-78 UniRef50_UPI00016C4DD0 Silent information regulator protein Sir2... 292 8e-78 UniRef50_C6A243 NAD-dependent deacetylase n=8 Tax=Euryarchaeota ... 284 2e-75 UniRef50_B1L5P3 NAD-dependent protein deacetylase, SIR2 family n... 284 2e-75 UniRef50_A9A3X3 Silent information regulator protein Sir2 n=4 Ta... 281 1e-74 UniRef50_Q8R9N6 NAD-dependent deacetylase 1 n=2 Tax=Thermoanaero... 281 2e-74 UniRef50_B0VHF0 NAD-dependent deacetylase (Regulatory protein SI... 280 3e-74 UniRef50_A8MBU4 NAD-dependent deacetylase n=14 Tax=cellular orga... 279 7e-74 UniRef50_A9GVG5 Transcriptional regulatory protein, Sir2 family ... 277 2e-73 UniRef50_Q2RZG2 Transcriptional regulator, Sir2 family n=2 Tax=B... 276 5e-73 UniRef50_Q72IV5 NAD-dependent deacetylase n=8 Tax=Bacteria RepID... 275 7e-73 UniRef50_C1FAB6 Putative nicotinic acid mononucleotide:5, 6-dime... 275 1e-72 UniRef50_D2R126 Silent information regulator protein Sir2 n=1 Ta... 271 1e-71 UniRef50_Q8ZU41 NAD-dependent deacetylase 1 n=4 Tax=Pyrobaculum ... 270 3e-71 UniRef50_Q5L014 NAD-dependent deacetylase 1 n=8 Tax=Firmicutes R... 270 4e-71 UniRef50_B1LZ70 Silent information regulator protein Sir2 n=6 Ta... 269 5e-71 UniRef50_B0SCR8 NAD-dependent protein deacetylase, SIR2 family n... 269 5e-71 UniRef50_C9R9I3 Silent information regulator protein Sir2 n=1 Ta... 269 5e-71 UniRef50_Q1QDL3 Silent information regulator protein Sir2 n=6 Ta... 269 6e-71 UniRef50_A7XXV9 Sirtuin 5 n=14 Tax=Eumetazoa RepID=A7XXV9_PIG 269 6e-71 UniRef50_C7FPB6 NAD-dependent protein deacetylase n=4 Tax=enviro... 268 9e-71 UniRef50_Q46ZJ9 Silent information regulator protein Sir2 n=4 Ta... 267 2e-70 UniRef50_A6LP94 Silent information regulator protein Sir2 n=1 Ta... 266 3e-70 UniRef50_Q9NXA8 NAD-dependent deacetylase sirtuin-5 n=37 Tax=Met... 266 4e-70 UniRef50_Q8F3Z6 NAD-dependent deacetylase n=4 Tax=Leptospira Rep... 266 4e-70 UniRef50_P66814 NAD-dependent deacetylase n=12 Tax=Mycobacterium... 266 5e-70 UniRef50_C1XSL0 NAD-dependent protein deacetylase, SIR2 family n... 266 6e-70 UniRef50_Q2LSF2 Sir2 family of NAD+-dependent deacetylase n=2 Ta... 264 2e-69 UniRef50_B5Y820 Putative NAD-dependent deacetylase 2 n=1 Tax=Cop... 263 4e-69 UniRef50_UPI000186E50A snf2 histone linker PHD ring helicase, pu... 263 5e-69 UniRef50_B0EU66 NAD-dependent deacetylase, putative n=2 Tax=Enta... 262 8e-69 UniRef50_C8QW70 Silent information regulator protein Sir2 n=1 Ta... 262 9e-69 UniRef50_A4J646 Silent information regulator protein Sir2 n=2 Ta... 261 9e-69 UniRef50_B1MER1 NAD-dependent deacetylase (Regulatory protein Si... 260 3e-68 UniRef50_Q1D737 NAD-dependent deacetylase n=1 Tax=Myxococcus xan... 260 3e-68 UniRef50_Q8Y015 NAD-dependent deacetylase n=20 Tax=cellular orga... 260 4e-68 UniRef50_Q2YZT2 Putative uncharacterized protein n=1 Tax=uncultu... 258 1e-67 UniRef50_D2QCS2 Silent information regulator protein Sir2 n=29 T... 257 2e-67 UniRef50_A8VRI8 NAD-dependent protein deacetylase SIR2 family-li... 256 5e-67 UniRef50_C0GT54 Silent information regulator protein Sir2 n=1 Ta... 256 5e-67 UniRef50_B3EMB2 Silent information regulator protein Sir2 n=2 Ta... 255 8e-67 UniRef50_B7IF48 NAD-dependent deacetylase n=1 Tax=Thermosipho af... 255 1e-66 UniRef50_B2A496 Silent information regulator protein Sir2 n=1 Ta... 255 1e-66 UniRef50_C8X5T0 Silent information regulator protein Sir2 n=3 Ta... 254 2e-66 UniRef50_Q8NSM4 NAD-dependent deacetylase n=15 Tax=Corynebacteri... 252 6e-66 UniRef50_Q88BY5 NAD-dependent deacetylase n=11 Tax=Pseudomonas R... 252 9e-66 UniRef50_B8F955 Silent information regulator protein Sir2 n=1 Ta... 251 2e-65 UniRef50_Q9WYW0 NAD-dependent deacetylase n=5 Tax=Thermotogaceae... 251 2e-65 UniRef50_D1A1X3 Silent information regulator protein Sir2 n=13 T... 251 2e-65 UniRef50_A6DC77 Silent information regulator protein Sir2 n=1 Ta... 251 2e-65 UniRef50_B9L9A0 NAD-dependent deacetylase n=4 Tax=Bacteria RepID... 250 3e-65 UniRef50_B5YJW3 NAD-dependent deacetylase n=1 Tax=Thermodesulfov... 249 5e-65 UniRef50_O07595 NAD-dependent deacetylase n=5 Tax=Bacillus RepID... 249 7e-65 UniRef50_B1I1N5 Silent information regulator protein Sir2 n=1 Ta... 248 9e-65 UniRef50_C6BY08 Silent information regulator protein Sir2 n=1 Ta... 248 1e-64 UniRef50_C2AS85 NAD-dependent protein deacetylase, SIR2 family n... 247 2e-64 UniRef50_Q9I4L0 NAD-dependent deacetylase 1 n=28 Tax=Bacteria Re... 247 3e-64 UniRef50_A7HL19 Silent information regulator protein Sir2 n=1 Ta... 247 3e-64 UniRef50_C6XKE4 Silent information regulator protein Sir2 n=1 Ta... 246 4e-64 UniRef50_Q97MB4 NAD-dependent deacetylase n=71 Tax=cellular orga... 246 5e-64 UniRef50_C6P8W9 Silent information regulator protein Sir2 n=2 Ta... 246 7e-64 UniRef50_B6KET2 NAD-dependent deacetylase, putative n=3 Tax=Toxo... 245 8e-64 UniRef50_C4GC77 Putative uncharacterized protein n=3 Tax=Clostri... 244 2e-63 UniRef50_Q81BT4 NAD-dependent deacetylase n=75 Tax=Bacillus RepI... 244 2e-63 UniRef50_D2RNB5 Silent information regulator protein Sir2 n=1 Ta... 243 3e-63 UniRef50_A0LG97 Silent information regulator protein Sir2 n=1 Ta... 243 4e-63 UniRef50_D1UAS5 Silent information regulator protein Sir2 n=1 Ta... 243 5e-63 UniRef50_C7RQR7 Silent information regulator protein Sir2 n=1 Ta... 243 6e-63 UniRef50_Q899G3 NAD-dependent deacetylase n=52 Tax=Bacteria RepI... 242 7e-63 UniRef50_Q67KQ0 NAD-dependent deacetylase n=1 Tax=Symbiobacteriu... 242 9e-63 UniRef50_C0GF21 Silent information regulator protein Sir2 n=1 Ta... 241 1e-62 UniRef50_C4FX59 Putative uncharacterized protein n=1 Tax=Catonel... 240 2e-62 UniRef50_Q8CJM9 NAD-dependent deacetylase 2 n=8 Tax=Actinomyceta... 240 3e-62 UniRef50_C5CGD1 Silent information regulator protein Sir2 n=3 Ta... 240 3e-62 UniRef50_Q0AY57 Regulatory protein, sir2 family n=1 Tax=Syntroph... 240 4e-62 UniRef50_Q5WKC8 NAD-dependent deacetylase n=7 Tax=Bacillaceae Re... 239 8e-62 UniRef50_A9AWG1 Silent information regulator protein Sir2 n=3 Ta... 238 9e-62 UniRef50_C4QC33 Chromatin regulatory protein sir2, putative n=1 ... 238 1e-61 UniRef50_Q6BVM7 DEHA2C01386p n=4 Tax=Saccharomycetaceae RepID=Q6... 238 1e-61 UniRef50_Q96EB6 NAD-dependent deacetylase sirtuin-1 n=36 Tax=Eut... 238 2e-61 UniRef50_B4VCV9 SIR2 family transcriptional regulator n=3 Tax=Ac... 237 2e-61 UniRef50_B3T8H4 Putative Sir2 family protein n=1 Tax=uncultured ... 237 3e-61 UniRef50_UPI0001C3128D Silent information regulator protein Sir2... 236 3e-61 UniRef50_C6CZ67 Silent information regulator protein Sir2 n=1 Ta... 236 3e-61 UniRef50_D0WS10 NAD-dependent deacetylase n=2 Tax=Actinomyces Re... 236 4e-61 UniRef50_Q8R984 NAD-dependent deacetylase 2 n=9 Tax=Thermoanaero... 236 4e-61 UniRef50_C1AAZ7 NAD-dependent deacetylase n=4 Tax=Bacteria RepID... 236 4e-61 UniRef50_A9AWT4 Silent information regulator protein Sir2 n=1 Ta... 236 5e-61 UniRef50_Q607X6 NAD-dependent deacetylase n=2 Tax=Gammaproteobac... 236 5e-61 UniRef50_D2VWA2 Silent information regulator family protein n=1 ... 236 6e-61 UniRef50_C6AKY4 Transcriptional regulator, Sir2 family n=5 Tax=P... 235 7e-61 UniRef50_Q8A3H9 NAD-dependent deacetylase n=29 Tax=Bacteria RepI... 235 8e-61 UniRef50_A6TNA0 Silent information regulator protein Sir2 n=2 Ta... 235 9e-61 UniRef50_Q1QTH0 Silent information regulator protein Sir2 n=3 Ta... 235 1e-60 UniRef50_B8FEP4 Silent information regulator protein Sir2 n=1 Ta... 235 1e-60 UniRef50_Q73KE1 NAD-dependent deacetylase n=2 Tax=Treponema RepI... 235 1e-60 UniRef50_UPI000179269F PREDICTED: similar to sirtuin n=1 Tax=Acy... 234 2e-60 UniRef50_C3IUP0 SIR2 n=2 Tax=Bacillus thuringiensis RepID=C3IUP0... 234 2e-60 UniRef50_A5UYK2 Silent information regulator protein Sir2 n=2 Ta... 233 3e-60 UniRef50_Q1RPU3 Zinc finger protein (Fragment) n=1 Tax=Ciona int... 233 3e-60 UniRef50_B0S0T6 Transcriptional regulator Sir2 family n=4 Tax=Cl... 233 4e-60 UniRef50_A9A0B2 NAD-dependent deacetylase n=1 Tax=Desulfococcus ... 233 4e-60 UniRef50_Q89LY4 NAD-dependent deacetylase 1 n=18 Tax=Proteobacte... 233 5e-60 UniRef50_B0EBU9 NAD-dependent deacetylase, putative n=3 Tax=Enta... 232 9e-60 UniRef50_D1N1D6 Silent information regulator protein Sir2 n=1 Ta... 231 1e-59 UniRef50_C1SNI0 NAD-dependent protein deacetylase, SIR2 family n... 231 1e-59 UniRef50_Q12Y78 NAD-dependent deacetylase, Sir2-like n=1 Tax=Met... 231 2e-59 UniRef50_UPI0001757F4E PREDICTED: similar to NAD-dependent deace... 230 3e-59 UniRef50_A8NWP2 Putative uncharacterized protein n=1 Tax=Coprino... 230 5e-59 UniRef50_Q3V7G9 NAD-dependent deacetylase (Regulatory protein si... 230 5e-59 UniRef50_D1B8J6 Silent information regulator protein Sir2 n=1 Ta... 229 5e-59 UniRef50_UPI000186F273 NAD-dependent deacetylase HST1, putative ... 229 6e-59 UniRef50_C3WP91 SIR2 family protein n=9 Tax=Fusobacterium RepID=... 229 6e-59 UniRef50_B2ARI4 Predicted CDS Pa_4_7390 (Fragment) n=1 Tax=Podos... 228 1e-58 UniRef50_D0NEH2 NAD-dependent histone deacetylase sir2-like prot... 228 1e-58 UniRef50_B8JAI9 Silent information regulator protein Sir2 n=5 Ta... 228 2e-58 UniRef50_C4XFR7 Putative uncharacterized protein n=1 Tax=Mycopla... 227 2e-58 UniRef50_Q8REC3 NAD-dependent deacetylase n=8 Tax=Fusobacterium ... 227 2e-58 UniRef50_C6X5T5 NAD-dependent protein deacetylase of SIR2 family... 227 3e-58 UniRef50_Q0CI01 Putative uncharacterized protein n=2 Tax=Leotiom... 227 3e-58 UniRef50_C4R311 NAD(+)-dependent histone deacetylase n=3 Tax=Sac... 226 4e-58 UniRef50_Q21921 NAD-dependent deacetylase SIR2 homolog n=2 Tax=C... 226 4e-58 UniRef50_UPI000051AA14 PREDICTED: similar to NAD-dependent deace... 226 4e-58 UniRef50_A9SDL4 SIR2 family protein n=2 Tax=Physcomitrella paten... 226 5e-58 UniRef50_B2VWU1 NAD-dependent deacetylase sirtuin-5 n=3 Tax=Leot... 226 7e-58 UniRef50_A1DG07 SIR2 family histone deacetylase, putative n=8 Ta... 225 8e-58 UniRef50_Q8CNF4 NAD-dependent deacetylase n=64 Tax=Staphylococcu... 225 8e-58 UniRef50_A3ZMQ7 Sir2 family, possible ADP ribosyltransferase n=1... 225 1e-57 UniRef50_D2Q7L2 SIR2 family protein n=13 Tax=Bifidobacterium Rep... 225 1e-57 UniRef50_A5USR3 Silent information regulator protein Sir2 n=3 Ta... 225 1e-57 UniRef50_UPI0001744E27 NAD-dependent protein deacetylases, SIR2 ... 225 1e-57 UniRef50_C6Y0J4 Silent information regulator protein Sir2 n=1 Ta... 225 1e-57 UniRef50_C1VAT1 NAD-dependent protein deacetylase, SIR2 family n... 225 1e-57 UniRef50_Q5KZE8 NAD-dependent deacetylase 2 n=8 Tax=Bacteria Rep... 225 1e-57 UniRef50_Q6C8C7 YALI0D20724p n=1 Tax=Yarrowia lipolytica RepID=Q... 225 2e-57 UniRef50_C5CY53 Silent information regulator protein Sir2 n=1 Ta... 224 2e-57 UniRef50_C8W9D8 Silent information regulator protein Sir2 n=2 Ta... 224 2e-57 UniRef50_C4Q5J6 Chromatin regulatory protein sir2, putative n=2 ... 224 2e-57 UniRef50_B9E751 Putative uncharacterized protein n=1 Tax=Macroco... 224 2e-57 UniRef50_A2QFF9 Complex: Sir2p is one of four Silent Information... 224 3e-57 UniRef50_UPI0001925E2D PREDICTED: similar to NAD-dependent deace... 223 5e-57 UniRef50_C5M5U2 NAD-dependent histone deacetylase SIR2 n=2 Tax=C... 222 1e-56 UniRef50_B0CZ35 Class I sirtuins SIR2 family protein n=2 Tax=Aga... 221 1e-56 UniRef50_D2RWQ5 Silent information regulator protein Sir2 n=2 Ta... 221 1e-56 UniRef50_A9BHU8 Silent information regulator protein Sir2 n=3 Ta... 221 2e-56 UniRef50_B0D7T5 Predicted protein n=3 Tax=Agaricales RepID=B0D7T... 221 2e-56 UniRef50_D2RCH9 Transcriptional regulator, Sir2 family n=7 Tax=B... 220 4e-56 UniRef50_A7EC18 Putative uncharacterized protein n=1 Tax=Sclerot... 220 4e-56 UniRef50_A3LRA1 Transcriptional regulatory protein n=4 Tax=Sacch... 220 4e-56 UniRef50_A0NQ49 Silent information regulator protein Sir2 n=2 Ta... 219 6e-56 UniRef50_D1B334 Silent information regulator protein Sir2 n=2 Ta... 219 7e-56 UniRef50_A9NEY3 Putative uncharacterized protein n=1 Tax=Acholep... 218 9e-56 UniRef50_Q9Y6E7 NAD-dependent ADP-ribosyltransferase sirtuin-4 n... 218 9e-56 UniRef50_C9M9P4 Transcriptional regulator, Sir2 family n=1 Tax=J... 218 1e-55 UniRef50_A4QUX8 Putative uncharacterized protein n=1 Tax=Magnapo... 218 2e-55 UniRef50_Q5V4Q5 NAD-dependent deacetylase n=3 Tax=Halobacteriace... 218 2e-55 UniRef50_Q9ZJW8 NAD-dependent deacetylase n=58 Tax=Bacteria RepI... 217 2e-55 UniRef50_UPI00015B57C0 PREDICTED: similar to GA18743-PA n=1 Tax=... 217 2e-55 UniRef50_O96505 SIR2 n=15 Tax=Arthropoda RepID=O96505_DROME 217 3e-55 UniRef50_A0C6J0 Chromosome undetermined scaffold_152, whole geno... 216 4e-55 UniRef50_Q07FY7 Sirtuin (Silent mating type information regulati... 216 5e-55 UniRef50_Q3A6W7 NAD-dependent protein deacetylases, SIR2 family ... 216 6e-55 UniRef50_A1ZHW6 NAD-dependent deacetylase n=2 Tax=Microscilla ma... 216 6e-55 UniRef50_Q54GV7 NAD(+)-dependent deacetylase, silent information... 216 7e-55 UniRef50_A2QWZ2 Function: human SIRT5 belongs to the Sir2-like p... 215 8e-55 UniRef50_Q9FE17 Sir2-like protein n=13 Tax=Viridiplantae RepID=Q... 215 1e-54 UniRef50_B3RLQ5 Putative uncharacterized protein n=1 Tax=Trichop... 215 1e-54 UniRef50_C0S0X1 NAD-dependent deacetylase sirtuin-2 n=3 Tax=Para... 214 2e-54 UniRef50_B2ATE5 Predicted CDS Pa_1_15580 n=4 Tax=Sordariomyceta ... 214 2e-54 UniRef50_Q9NTG7 NAD-dependent deacetylase sirtuin-3, mitochondri... 214 2e-54 UniRef50_Q7ZVK3 NAD-dependent deacetylase sirtuin-2 n=19 Tax=Euk... 214 2e-54 UniRef50_UPI00019255E8 PREDICTED: similar to sirtuin n=2 Tax=Hyd... 213 3e-54 UniRef50_D2A3P1 Putative uncharacterized protein GLEAN_14968 n=1... 213 3e-54 UniRef50_B6GXN1 Pc12g08000 protein n=1 Tax=Penicillium chrysogen... 213 4e-54 UniRef50_B3WAV7 NAD-dependent deacetylase (Regulatory protein SI... 213 4e-54 UniRef50_D1Y076 Transcriptional regulator, Sir2 family n=1 Tax=P... 213 5e-54 UniRef50_A8PZF9 NAD-dependent deacetylase SIRT1, putative n=1 Ta... 213 5e-54 UniRef50_Q5R1T8 NAD-dependent deacetylase sirtuin 2 homolog n=2 ... 213 5e-54 UniRef50_B9L4G7 NAD-dependent deacetylase 1 (Regulatory protein ... 213 5e-54 UniRef50_A3LN35 NAD-dependent histone deacetylase SIR2 (Regulato... 213 5e-54 UniRef50_B3QYR0 Silent information regulator protein Sir2 n=1 Ta... 213 5e-54 UniRef50_Q5HU51 NAD-dependent deacetylase n=15 Tax=Campylobacter... 212 7e-54 UniRef50_C3YDA2 Putative uncharacterized protein n=1 Tax=Branchi... 211 1e-53 UniRef50_C4M6Q0 Sir2 family transcriptional regulator, putative ... 211 2e-53 UniRef50_Q9I7I7 Sirt2 n=8 Tax=Drosophila RepID=Q9I7I7_DROME 211 2e-53 UniRef50_C5L8Y4 Chromatin regulatory protein sir2, putative n=2 ... 211 2e-53 UniRef50_B3RYT4 Putative uncharacterized protein (Fragment) n=1 ... 210 3e-53 UniRef50_C5GPX3 SIR2 family histone deacetylase n=2 Tax=Ajellomy... 210 3e-53 UniRef50_C4WX51 ACYPI009170 protein n=1 Tax=Acyrthosiphon pisum ... 210 3e-53 UniRef50_Q6BPH5 DEHA2E13596p n=4 Tax=Saccharomycetaceae RepID=Q6... 210 3e-53 UniRef50_Q6C219 YALI0F11583p n=1 Tax=Yarrowia lipolytica RepID=Q... 210 3e-53 UniRef50_D2S8Y6 Silent information regulator protein Sir2 n=1 Ta... 210 4e-53 UniRef50_C4XZ95 Putative uncharacterized protein n=1 Tax=Clavisp... 210 4e-53 UniRef50_C1BNZ8 NAD-dependent deacetylase sirtuin-2 n=3 Tax=Cali... 210 4e-53 UniRef50_A7RLD5 Predicted protein (Fragment) n=1 Tax=Nematostell... 210 4e-53 UniRef50_C4DIV4 NAD-dependent protein deacetylase, SIR2 family n... 209 5e-53 UniRef50_Q9USN7 NAD-dependent deacetylase hst2 n=1 Tax=Schizosac... 209 5e-53 UniRef50_D0LVG3 Silent information regulator protein Sir2 n=1 Ta... 209 6e-53 UniRef50_B9GC62 Putative uncharacterized protein n=1 Tax=Oryza s... 209 9e-53 UniRef50_A7SK95 Predicted protein n=1 Tax=Nematostella vectensis... 208 1e-52 UniRef50_Q298C7 GA18650 n=3 Tax=Drosophila RepID=Q298C7_DROPS 208 1e-52 UniRef50_C3XIH7 NAD-dependent deacetylase n=4 Tax=Campylobactera... 208 1e-52 UniRef50_A8NIK3 Putative uncharacterized protein n=1 Tax=Coprino... 207 2e-52 UniRef50_B7U9B0 Sirtuin 3 n=7 Tax=Chordata RepID=B7U9B0_PIG 207 3e-52 UniRef50_UPI00006CA40C transcriptional regulator, Sir2 family pr... 207 3e-52 UniRef50_C5LN96 Neurofilament triplet L protein, putative n=5 Ta... 207 3e-52 UniRef50_B3L8U3 Transcriptional regulatory protein sir2 homologu... 207 3e-52 UniRef50_A4S2L7 Predicted protein n=2 Tax=Ostreococcus RepID=A4S... 206 4e-52 UniRef50_C1DBX3 NAD-dependent deacetylase n=1 Tax=Laribacter hon... 206 4e-52 UniRef50_Q1YSP9 NAD-dependent deacetylase n=1 Tax=gamma proteoba... 206 5e-52 UniRef50_A5DNV7 Putative uncharacterized protein n=2 Tax=Pichia ... 206 7e-52 UniRef50_B0E5U4 NAD-dependent deacetylase sirtuin-2, putative n=... 205 1e-51 UniRef50_A1ZPG8 NAD-dependent deacetylase n=1 Tax=Microscilla ma... 205 1e-51 UniRef50_Q8IXJ6 NAD-dependent deacetylase sirtuin-2 n=43 Tax=Cho... 205 1e-51 UniRef50_Q7VIN2 NAD-dependent deacetylase n=1 Tax=Helicobacter h... 204 1e-51 UniRef50_D2NR35 NAD-dependent protein deacetylase n=2 Tax=Rothia... 204 2e-51 UniRef50_Q750H1 AGL018Cp n=1 Tax=Eremothecium gossypii RepID=Q75... 204 2e-51 UniRef50_C4QWX8 Conserved NAD+ dependent histone deacetylase of ... 204 2e-51 UniRef50_C0W513 NAD-dependent deacetylase 1 n=4 Tax=Actinomyceta... 204 2e-51 UniRef50_C5L233 NAD-dependent deacetylase sirtuin-5, putative n=... 204 2e-51 UniRef50_A9V9C1 Predicted protein n=1 Tax=Monosiga brevicollis R... 204 3e-51 UniRef50_B6JXE7 Sir2 family histone deacetylase Hst2 n=1 Tax=Sch... 204 3e-51 UniRef50_Q71W25 NAD-dependent deacetylase n=32 Tax=Bacilli RepID... 203 3e-51 UniRef50_B3RZX6 Putative uncharacterized protein n=1 Tax=Trichop... 203 3e-51 UniRef50_Q8N6T7 NAD-dependent deacetylase sirtuin-6 n=24 Tax=Met... 203 4e-51 UniRef50_C5MB00 NAD-dependent histone deacetylase SIR2 n=2 Tax=S... 203 6e-51 UniRef50_C7TMK6 NAD-dependent protein deacetylase, SIR2 family n... 203 6e-51 UniRef50_Q5KDE0 NAD-dependent histone deacetylase, putative n=2 ... 202 8e-51 UniRef50_Q8R104 NAD-dependent deacetylase sirtuin-3 n=14 Tax=Deu... 202 9e-51 UniRef50_P53686 NAD-dependent deacetylase HST2 n=7 Tax=Saccharom... 202 1e-50 UniRef50_O59923 NAD-dependent histone deacetylase SIR2 n=4 Tax=C... 202 1e-50 UniRef50_Q5GUM2 SIR2-like regulatory protein n=5 Tax=cellular or... 201 1e-50 UniRef50_Q4UZX0 NAD-dependent deacetylase n=94 Tax=Bacteria RepI... 201 2e-50 UniRef50_Q8FUC8 NAD-dependent deacetylase 1 n=11 Tax=Corynebacte... 201 2e-50 UniRef50_C1BMY9 NAD-dependent deacetylase sirtuin-2 n=3 Tax=Cali... 201 2e-50 UniRef50_A1U4N6 Silent information regulator protein Sir2 n=2 Ta... 201 2e-50 UniRef50_UPI000186DFC4 NAD-dependent deacetylase sirtuin-4, puta... 200 3e-50 UniRef50_Q839C6 NAD-dependent deacetylase n=22 Tax=Bacilli RepID... 200 3e-50 UniRef50_B3S4A5 Putative uncharacterized protein n=1 Tax=Trichop... 200 4e-50 UniRef50_A4VDQ9 Chromatin regulatory protein sir2 n=1 Tax=Tetrah... 200 4e-50 UniRef50_A9DQY7 Silent information regulator protein Sir2 n=1 Ta... 200 4e-50 UniRef50_Q75DM1 ABL004Wp n=1 Tax=Eremothecium gossypii RepID=Q75... 199 5e-50 Sequences not found previously or not previously below threshold: UniRef50_Q4P1X1 Putative uncharacterized protein n=1 Tax=Ustilag... 201 2e-50 >UniRef50_D0KGP3 Silent information regulator protein Sir2 n=11 Tax=Proteobacteria RepID=D0KGP3_PECWW Length = 276 Score = 339 bits (871), Expect = 4e-92, Method: Composition-based stats. Identities = 187/229 (81%), Positives = 203/229 (88%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 M+KPRV+VLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGF RDPELVQ FYNARRR Sbjct: 36 MKKPRVVVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFQRDPELVQEFYNARRR 95 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 QLQQPEI PNAAHLALA L+ L D F L+TQNIDNLHERAG+ VIHMHGELLK+RCSQ Sbjct: 96 QLQQPEIVPNAAHLALANLEAMLEDNFQLITQNIDNLHERAGSRRVIHMHGELLKIRCSQ 155 Query: 121 SGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSG 180 SGQ+ +WT D+ ++CHCCQFPAPLRPHVVWFGEMPL MD+IY ALS AD FIAIGTSG Sbjct: 156 SGQIFEWTDDLAAGERCHCCQFPAPLRPHVVWFGEMPLHMDKIYHALSQADYFIAIGTSG 215 Query: 181 HVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFV 229 HVYPAAGFVHEA HGA+T+ELNLEPSQV ++F EK YGPAS VVPEFV Sbjct: 216 HVYPAAGFVHEAHSHGAYTLELNLEPSQVESQFDEKIYGPASAVVPEFV 264 >UniRef50_Q9CM50 NAD-dependent deacetylase n=5 Tax=Proteobacteria RepID=NPD_PASMU Length = 234 Score = 322 bits (827), Expect = 4e-87, Method: Composition-based stats. Identities = 152/229 (66%), Positives = 184/229 (80%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQ 64 R++VLTGAGISAESGIRTFRA DGLWE H V++VATPEGF R+P+LVQ FYN RR+QL Sbjct: 6 RIVVLTGAGISAESGIRTFRATDGLWENHPVDEVATPEGFARNPKLVQRFYNERRKQLFS 65 Query: 65 PEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQV 124 +I PNAAH ALA+L+ LGD L+VTQN+DNLHERAG+ N+IHMHGELLKVRC +SG++ Sbjct: 66 DQIAPNAAHFALAELEKKLGDNLLIVTQNVDNLHERAGSKNLIHMHGELLKVRCVKSGKI 125 Query: 125 LDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGHVYP 184 DW GD+ DKC CC LRPH+VWFGEMPL M++I ALS D FI+IGTSG+VYP Sbjct: 126 YDWQGDIGEHDKCLCCTPTQILRPHIVWFGEMPLEMEKIQTALSECDYFISIGTSGNVYP 185 Query: 185 AAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLL 233 AAGFV EA +GAHTVELNLEPSQV + F E +YG A+++VP ++ + L Sbjct: 186 AAGFVREALFYGAHTVELNLEPSQVRSSFDECHYGKATELVPHYLAQFL 234 >UniRef50_B8KDE3 NAD-dependent deacetylase n=4 Tax=Gammaproteobacteria RepID=B8KDE3_VIBPA Length = 245 Score = 312 bits (801), Expect = 5e-84, Method: Composition-based stats. Identities = 155/237 (65%), Positives = 189/237 (79%) Query: 4 PRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQ 63 V++LTGAGISAESGI+TFRA DGLWE+HR+EDVATPEGF RDP+LVQ FYN RR LQ Sbjct: 6 RNVVILTGAGISAESGIQTFRAQDGLWEDHRIEDVATPEGFARDPDLVQDFYNKRRIMLQ 65 Query: 64 QPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQ 123 +P I+PNAAH+AL +L+ L ++TQNIDNLHER G++NVIHMHGELLK RCS S Q Sbjct: 66 EPHIEPNAAHIALGQLEAELDGTVTVITQNIDNLHERGGSSNVIHMHGELLKARCSVSNQ 125 Query: 124 VLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGHVY 183 V++ G++ D CHCCQ P+ +RPHVVWFGEMPL M EIY +L AD+FI+IGTSG V+ Sbjct: 126 VVEELGEIKTGDLCHCCQMPSQMRPHVVWFGEMPLRMGEIYQSLEDADLFISIGTSGVVF 185 Query: 184 PAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKGLKAGS 240 PAAGFVH+AK+HGAHT+E+NLEPS V +EF EK YG AS VP+ VE++L K + Sbjct: 186 PAAGFVHDAKMHGAHTIEINLEPSAVESEFEEKRYGKASVEVPKLVEEILALQKPQA 242 >UniRef50_D2LLI1 Silent information regulator protein Sir2 n=3 Tax=Aciduliprofundum boonei T469 RepID=D2LLI1_9EURY Length = 245 Score = 307 bits (788), Expect = 2e-82, Method: Composition-based stats. Identities = 94/239 (39%), Positives = 130/239 (54%), Gaps = 4/239 (1%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 + R++ LTGAGISAESGI TFR GLWE + VE VAT EGF+RDP LV FY+ RRR Sbjct: 11 LSAKRIVALTGAGISAESGIPTFRGTGGLWEGYPVEKVATIEGFERDPALVWKFYDERRR 70 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 + + +PN AH LA ++ F ++TQNID LH RAG+ NV+ +HG + +V+C++ Sbjct: 71 NI--AKARPNRAHEVLALFENLY--DFWVITQNIDGLHSRAGSKNVVELHGNIWRVKCTE 126 Query: 121 SGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSG 180 G E C + LRP VVWFGE +D+ Y D+ + IGTS Sbjct: 127 CGIRYYNYEVPLREIPPKCKRCGGLLRPDVVWFGEPVYDVDKAYELTESCDVMLVIGTSA 186 Query: 181 HVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKGLKAG 239 VYPAA A GA +E+N + + + A++ + E LL+ + Sbjct: 187 QVYPAAYLPRLAWSKGAKIIEINPQETPISRYANFVIREKATKALDELYRGLLRAFQEE 245 >UniRef50_A0LP75 Silent information regulator protein Sir2 n=3 Tax=Bacteria RepID=A0LP75_SYNFM Length = 244 Score = 303 bits (778), Expect = 3e-81, Method: Composition-based stats. Identities = 98/229 (42%), Positives = 135/229 (58%), Gaps = 6/229 (2%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 V+VLTGAGISAESG+ TFR GLW +R D+ATPE F+ DP+LV FY RR+ L Sbjct: 20 AENVVVLTGAGISAESGVPTFRGEGGLWRTYRATDLATPEAFENDPKLVWEFYGWRRQLL 79 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG 122 + PN H ALA+L+ + RF L+TQNID LH++AG+ N++ +HG L VRC++ G Sbjct: 80 APLD--PNPGHYALAELERRI-PRFTLITQNIDGLHQKAGSANILELHGNLWWVRCTRCG 136 Query: 123 QVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEM--PLGMDEIYMALSMADIFIAIGTSG 180 + + PE C LRPHVVWFGEM P +D+ Y A+ + + +GTSG Sbjct: 137 SLTEDRTVPLPE-LPRCGSCRGLLRPHVVWFGEMLEPKILDQAYEAIRDCGVMLVVGTSG 195 Query: 181 HVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFV 229 V PAA A+ GA E+NL+P+ + G A +++P + Sbjct: 196 TVQPAASMGVIARKQGATVAEVNLDPTPYSGAYDISISGKAGEILPRLL 244 >UniRef50_Q6MJJ2 NAD-dependent deacetylase n=8 Tax=Proteobacteria RepID=NPD_BDEBA Length = 235 Score = 298 bits (763), Expect = 1e-79, Method: Composition-based stats. Identities = 124/231 (53%), Positives = 158/231 (68%), Gaps = 2/231 (0%) Query: 4 PRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQ 63 +++LTGAGISAESGIRTFR DGLWE+HR+EDVATPE F R+P LVQ FYN RR QL+ Sbjct: 7 KNIVILTGAGISAESGIRTFRDQDGLWEDHRIEDVATPEAFARNPALVQRFYNLRRAQLR 66 Query: 64 QPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQ 123 P + PN AH AL L++ FLLVTQN+DNLH RAG+ N++HMHG L +V C + Sbjct: 67 DPNLAPNPAHQALVDLENLWEGNFLLVTQNVDNLHRRAGSKNLLHMHGRLDRVFCLHCDE 126 Query: 124 VLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGHVY 183 +W D+ + C C +RP +VWFGEMP M+EIY AL AD FI+IGTSG+VY Sbjct: 127 HFEWLLDLAVDQPCPHCGRKGGVRPDIVWFGEMPHHMEEIYEALDKADYFISIGTSGNVY 186 Query: 184 PAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLK 234 PAAGFV A A +E+NL+ +++ F E + GPAS VP F+ + L+ Sbjct: 187 PAAGFVRLA--WKAKKIEINLKDTEISPAFDEHFVGPASTEVPRFITQFLE 235 >UniRef50_C8S918 Silent information regulator protein Sir2 n=1 Tax=Ferroglobus placidus DSM 10642 RepID=C8S918_FERPL Length = 253 Score = 294 bits (753), Expect = 2e-78, Method: Composition-based stats. Identities = 90/234 (38%), Positives = 127/234 (54%), Gaps = 11/234 (4%) Query: 7 LVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQPE 66 +V TGAG+SAESGI TFR DGLW ++VA+ GF R+P F R + + + Sbjct: 21 VVFTGAGVSAESGIPTFRGNDGLWRRWDPDEVASIYGFRRNPRKFWEF---SRELIVKVK 77 Query: 67 IQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVLD 126 QPN AH A+A+L+ +G ++TQNID LH+RAG+ V+ +HG + V C G+ Sbjct: 78 AQPNPAHYAIAELE-KMGLVKAVITQNIDMLHQRAGSKRVLELHGSMQYVDCLDCGKTYK 136 Query: 127 WTG-----DVTPEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMADIFIAIGTS 179 W + DK C L+P VV+FGE + E AD+FI +G+S Sbjct: 137 WEEIERFLEKGEIDKIRCECGSIYLKPRVVFFGEPLPSNVLSEAMEESRRADVFIVVGSS 196 Query: 180 GHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLL 233 VYPAA AK HGA + +NLEP+ + F G A +V+PE V+++ Sbjct: 197 LVVYPAAYLPVIAKEHGAKLIIVNLEPTMKDHIFDVVIRGKAGEVMPEIVKRVK 250 >UniRef50_O30124 NAD-dependent deacetylase 2 n=18 Tax=cellular organisms RepID=NPD2_ARCFU Length = 253 Score = 292 bits (749), Expect = 6e-78, Method: Composition-based stats. Identities = 86/239 (35%), Positives = 129/239 (53%), Gaps = 10/239 (4%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 + +V TGAGISAESGI TFR DGLW ++ E+VA+ GF R+P F + + Sbjct: 14 KSKHAVVFTGAGISAESGIPTFRGEDGLWRKYDPEEVASISGFKRNPRAFWEFSMEMKDK 73 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 L +PN AH A+A+L+ +G ++TQNID LH+RAG+ V+ +HG + K+ C Sbjct: 74 LF---AEPNPAHYAIAELER-MGIVKAVITQNIDMLHQRAGSRRVLELHGSMDKLDCLDC 129 Query: 122 GQVLDWTG---DVTPEDKCHCCQFPAP-LRPHVVWFGEMPLG--MDEIYMALSMADIFIA 175 + DW+ D + C + + ++P VV FGE + E D F+ Sbjct: 130 HETYDWSEFVEDFNKGEIPRCRKCGSYYVKPRVVLFGEPLPQRTLFEAIEEAKHCDAFMV 189 Query: 176 IGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLK 234 +G+S VYPAA + AK GA + +N EP+ F K G A +V+P+ VE++ + Sbjct: 190 VGSSLVVYPAAELPYIAKKAGAKMIIVNAEPTMADPIFDVKIIGKAGEVLPKIVEEVKR 248 >UniRef50_UPI00016C4DD0 Silent information regulator protein Sir2 n=1 Tax=Gemmata obscuriglobus UQM 2246 RepID=UPI00016C4DD0 Length = 249 Score = 292 bits (748), Expect = 8e-78, Method: Composition-based stats. Identities = 103/232 (44%), Positives = 141/232 (60%), Gaps = 5/232 (2%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 V VLTGAGISAESG+ TFRA+DGLWE HR+EDVA+P+G+DR+P LV FYNARR + Sbjct: 20 AKSVCVLTGAGISAESGVPTFRASDGLWEGHRIEDVASPDGWDRNPALVWQFYNARRANV 79 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG 122 ++PN H AL L+D GD F LVTQN+D LH +AG+ V+ +HG L + RC+ Sbjct: 80 --ATVKPNPGHFALVALEDRFGDNFKLVTQNVDGLHLQAGSRRVLEIHGSLRQTRCTVCE 137 Query: 123 QVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMADIFIAIGTSG 180 V + G D C Q LRPH+VWFGE E ++ S D + +GTS Sbjct: 138 AVTNR-GLEPLGDAPECPQCHGRLRPHIVWFGEGLPDDIWMEAMVSASECDTLLVVGTSA 196 Query: 181 HVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 V+PAA V A+ GA +E+N+ ++ YGP+ +V+P+ +++L Sbjct: 197 VVHPAASLVPIARRKGATVIEVNITRTEASAYADIGLYGPSGEVLPKLLQRL 248 >UniRef50_C6A243 NAD-dependent deacetylase n=8 Tax=Euryarchaeota RepID=NPD_THESM Length = 255 Score = 284 bits (727), Expect = 2e-75, Method: Composition-based stats. Identities = 91/251 (36%), Positives = 139/251 (55%), Gaps = 18/251 (7%) Query: 2 EKPRVLV-------LTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAF 54 E PR++ TGAG+SAESGI TFR GLWE +R+E+VATPE F +DP LV +F Sbjct: 4 EAPRIIAHSRFLIAFTGAGVSAESGIPTFRDRGGLWENYRIEEVATPEAFRKDPNLVWSF 63 Query: 55 YNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELL 114 Y R + + +PN AHLALA+L+ +G ++TQNIDNLH AGN +++ +HG + Sbjct: 64 YKMRMKIM--KGAKPNNAHLALAELE-KMGILKAVITQNIDNLHREAGNQHIVELHGNIY 120 Query: 115 KVRCSQSGQVLDWTGDVTPEDK------CHCCQFPAPLRPHVVWFGEMPL--GMDEIYMA 166 +V+C++ + + ED C + + LRP VVWFGE + + + Sbjct: 121 RVKCTRCDYMENLLESGKLEDFLKEKNLPKCPECASLLRPDVVWFGEPLPQEALQKAFKL 180 Query: 167 LSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVP 226 AD+ + +GTS V+PAA + K +G +E+N + S + G A +V+ Sbjct: 181 AERADVCLVVGTSAQVFPAAYVPYIVKDNGGSVIEINTKESGITPIADVFIRGKAGEVMQ 240 Query: 227 EFVEKLLKGLK 237 + K+ + L+ Sbjct: 241 SLLVKVKRCLE 251 >UniRef50_B1L5P3 NAD-dependent protein deacetylase, SIR2 family n=1 Tax=Candidatus Korarchaeum cryptofilum OPF8 RepID=B1L5P3_KORCO Length = 250 Score = 284 bits (727), Expect = 2e-75, Method: Composition-based stats. Identities = 86/234 (36%), Positives = 127/234 (54%), Gaps = 8/234 (3%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 +V+ TGAGISAE+GI TFR GLWE++ E++ATP+ F RDP+LV +Y R + Sbjct: 17 SGKVVAFTGAGISAEAGIPTFRGKGGLWEKYDPEELATPQAFFRDPKLVWDWYLWRMSII 76 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG 122 +P AH LA +D G ++TQN+D LH+RAG+ N++ +HG + ++RC+ Sbjct: 77 --ARARPTPAHEILALWEDK-GILKGVITQNVDGLHQRAGSKNLVELHGSIWRIRCTSCD 133 Query: 123 QVLDWTGDVTPEDKCHCC-QFPAPLRPHVVWFGEMPLGMDEIYMA---LSMADIFIAIGT 178 + PE C + + +RP VVWF E PL DE A + A + + IGT Sbjct: 134 NKVYLGFGNLPERVPPECDRCGSIMRPDVVWFYE-PLPRDEWMRAEDMIRSASLLLIIGT 192 Query: 179 SGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 SG V PAA A + A VE+N E + + + + AS++ + E L Sbjct: 193 SGLVMPAATLPMMALRNNATLVEINPEETNLSSLAKFRVREGASRIFVDLNEML 246 >UniRef50_A9A3X3 Silent information regulator protein Sir2 n=4 Tax=marine archaeal group 1 RepID=A9A3X3_NITMS Length = 242 Score = 281 bits (720), Expect = 1e-74, Method: Composition-based stats. Identities = 85/236 (36%), Positives = 126/236 (53%), Gaps = 9/236 (3%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 +++ +TGAGIS ESGI TFR DGLW + +AT + F DP+LV +YN RR + Sbjct: 14 AKKIVFVTGAGISQESGIPTFRGKDGLWRNYDAMKLATIDAFYDDPKLVWEWYNERRHNI 73 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG 122 PN H A+A+L+ L TQNID LH++AG+T V+ +HG ++K++C+ Sbjct: 74 FSAN--PNQGHKAIAELEKFADVVSL--TQNIDGLHQKAGSTKVLELHGSIVKIKCTVCD 129 Query: 123 QVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMADIFIAIGTSG 180 + D T + C+ + LRP VVWFGE E + + D+ I +GTS Sbjct: 130 FSDEIMTDFT--ENPPLCKCGSILRPDVVWFGESLPQDVWQEAIIHANQCDLMIIVGTSL 187 Query: 181 HVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKGL 236 V PA AK + A +E+N E +++ +E ++ +PEFV L K L Sbjct: 188 VVSPANTLPIYAKQNNAMLIEINPENTEMSSEMDLVIRNTSANALPEFV-SLFKNL 242 >UniRef50_Q8R9N6 NAD-dependent deacetylase 1 n=2 Tax=Thermoanaerobacteraceae RepID=NPD1_THETN Length = 242 Score = 281 bits (719), Expect = 2e-74, Method: Composition-based stats. Identities = 87/225 (38%), Positives = 128/225 (56%), Gaps = 7/225 (3%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 + +VLTGAGIS ESGI TFR DGLW+++ E++ATP F R+P LV +Y+ RRR Sbjct: 12 QSNLTVVLTGAGISKESGIPTFRGEDGLWKKYNPEELATPWAFQRNPALVWEWYDYRRRI 71 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 + + +PN HL +A+ ++ ++TQN+D LHE AG+TNVI +HG + KV+C++ Sbjct: 72 I--SKAKPNKCHLLIAEFEERF-KNVRVITQNVDGLHEAAGSTNVIELHGNIWKVKCTKC 128 Query: 122 GQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALS---MADIFIAIGT 178 + C + + +RP VVWFGE PL D++ A+ AD+FI IGT Sbjct: 129 DFRGINREVPLSKIPPECPKCGSIVRPDVVWFGE-PLPSDKLTEAMELSQRADLFIVIGT 187 Query: 179 SGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQ 223 S V PAA A GA VE++ E + + + + A + Sbjct: 188 SLMVQPAASLPFLALERGAFVVEVSPEETPLSRKAHLFFQMGAVE 232 >UniRef50_B0VHF0 NAD-dependent deacetylase (Regulatory protein SIR2 homolog) n=1 Tax=Candidatus Cloacamonas acidaminovorans RepID=B0VHF0_9BACT Length = 237 Score = 280 bits (717), Expect = 3e-74, Method: Composition-based stats. Identities = 111/226 (49%), Positives = 135/226 (59%), Gaps = 2/226 (0%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQ 64 VLVLTGAGISAESGIRTFR + GLWE HRVEDVATPE F+ +P V FY R+R Sbjct: 9 NVLVLTGAGISAESGIRTFRDSGGLWENHRVEDVATPEAFNSNPVKVWEFY--RQRYQDS 66 Query: 65 PEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQV 124 +PN AHLAL KL+ LGD FLLVTQN+D LH +AG+ V+ MHG L C++ Sbjct: 67 ISSKPNPAHLALVKLEQFLGDNFLLVTQNVDCLHIKAGSKRVLEMHGSLANCICTKCHSK 126 Query: 125 LDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGHVYP 184 L + C LRP +VWFGE+P ++ I AL +FI +GTSG VYP Sbjct: 127 LAIKDIDLTQPIPLCPFCNGILRPDIVWFGEIPHYLNIIDDALRKCSVFIIVGTSGVVYP 186 Query: 185 AAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVE 230 AAGFV AKL GA T+ +NL E Y G + ++P V Sbjct: 187 AAGFVLTAKLMGAKTIAINLGKPDNLAYIDEFYQGKSGDILPGLVA 232 >UniRef50_A8MBU4 NAD-dependent deacetylase n=14 Tax=cellular organisms RepID=NPD_CALMQ Length = 257 Score = 279 bits (714), Expect = 7e-74, Method: Composition-based stats. Identities = 81/242 (33%), Positives = 121/242 (50%), Gaps = 8/242 (3%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 + TGAGIS ESGI FR GLW +A+ + + DP+ FY R R L Sbjct: 20 SRHAIAFTGAGISTESGIPDFRGPQGLWRRFDP-ALASIDYLNTDPKGFWEFYIERFRVL 78 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG 122 +PN AHLALA+L+ LG ++TQNIDNLH+ AG+ NVI +HG V C + Sbjct: 79 N--NARPNKAHLALAELE-KLGIIKYVITQNIDNLHQSAGSINVIELHGNYTTVYCMRCK 135 Query: 123 QVLDWT----GDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGT 178 +T E+ C + LRP+VV FGE ++ +++D+ + +G+ Sbjct: 136 TQYPFTLALRKYEEGENPPRCPKCGGILRPNVVLFGEPVNEINRALEIAALSDVALVVGS 195 Query: 179 SGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKGLKA 238 S VYPAA K HG + +NLEP+ + + AS+ + + ++ + A Sbjct: 196 SLTVYPAAYVPLVVKEHGGRLIIINLEPTDYDDYADVVLHCSASEALDLVLNEVKGIMAA 255 Query: 239 GS 240 G+ Sbjct: 256 GN 257 >UniRef50_A9GVG5 Transcriptional regulatory protein, Sir2 family n=1 Tax=Sorangium cellulosum 'So ce 56' RepID=A9GVG5_SORC5 Length = 269 Score = 277 bits (710), Expect = 2e-73, Method: Composition-based stats. Identities = 99/252 (39%), Positives = 134/252 (53%), Gaps = 26/252 (10%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 ++ VLTGAG+SAESGI TFR A GLW + +A+PE + RDP LV FYN RR Sbjct: 16 ARKIAVLTGAGVSAESGIPTFRGAGGLWRRYEATSLASPEAWRRDPGLVWEFYNHRRE-- 73 Query: 63 QQPEIQPNAAHLALAKLQ---DALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCS 119 + PN H ALA+L+ G F L+TQNID LHE+AG+ + + +HG L +VRC Sbjct: 74 RALGCAPNPGHHALAQLEARWREAGRAFTLITQNIDGLHEKAGSRSPVRLHGSLWQVRCL 133 Query: 120 QSGQVLD---------WTGDVTPEDKC----------HCCQFPAPLRPHVVWFGEMPLGM 160 G V + + G +P+ + C LRPHVVWFGE Sbjct: 134 SCGSVTENRDVPITPAFAGSGSPDPEAPARRFTAAELPRCGCGGVLRPHVVWFGEALQES 193 Query: 161 DEIYMA--LSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYY 218 D A + D+ + +GTS VYPAAGFV AK HGA E+N+EPS + + Sbjct: 194 DLAAAAAGVEGCDLLLVVGTSAVVYPAAGFVPMAKRHGALIAEVNVEPSAISGLCDVVFT 253 Query: 219 GPASQVVPEFVE 230 G + ++P ++ Sbjct: 254 GGSGAILPSLLD 265 >UniRef50_Q2RZG2 Transcriptional regulator, Sir2 family n=2 Tax=Bacteria RepID=Q2RZG2_SALRD Length = 252 Score = 276 bits (707), Expect = 5e-73, Method: Composition-based stats. Identities = 93/237 (39%), Positives = 129/237 (54%), Gaps = 8/237 (3%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 +E V VLTGAGISAESGI TFR GLWEE +++A E F +PELVQ +Y RR Sbjct: 13 VEAGHVAVLTGAGISAESGIPTFRDPGGLWEEFDPQELANVEAFLDNPELVQGWYRHRRE 72 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 ++ + PNA H ALA L+ + +VTQN+D+LH RA + VI +HG + C Sbjct: 73 VVE--DAAPNAGHHALADLEAHVPS-MAVVTQNVDDLHNRAETSTVIELHGNITDNYCMD 129 Query: 121 SGQVLDWTGDVT---PEDKCHCCQFPAPLRPHVVWFGEM--PLGMDEIYMALSMADIFIA 175 Q + + C +RP VVWFGEM P M++ AD+F++ Sbjct: 130 CEQAVGAAAVDAAIQDGEPARCPDCGGLVRPDVVWFGEMLPPDAMEQADATTEQADVFLS 189 Query: 176 IGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 +GTS VYPAA A+ GA+ E+N + + V ++ E GPA V+P V+ + Sbjct: 190 VGTSAVVYPAARLPVAAREQGAYVAEVNPDTTGVTDDVHETIRGPAGDVLPALVDAV 246 >UniRef50_Q72IV5 NAD-dependent deacetylase n=8 Tax=Bacteria RepID=NPD_THET2 Length = 254 Score = 275 bits (705), Expect = 7e-73, Method: Composition-based stats. Identities = 95/233 (40%), Positives = 126/233 (54%), Gaps = 9/233 (3%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 E RV VLTGAGIS SGI TFR A+GLW+ D ATPE + RDPE V A+Y R ++ Sbjct: 13 EAKRVAVLTGAGISKPSGIPTFRDAEGLWKNFNPLDYATPEAYARDPEKVWAWYAWRIQK 72 Query: 62 LQQPEIQPNAAHLALAKLQDAL---GDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRC 118 ++ E +PN AH AL +L+ + G FLLVTQN+D LH RAG+ N++ +HG LL+ RC Sbjct: 73 VR--EAKPNPAHYALVELERRILSRGGSFLLVTQNVDGLHARAGSQNLVELHGNLLRARC 130 Query: 119 SQSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPL--GMDEIYMALSMADIFIAI 176 G+ P C C A RP VVWFGE+ + A + AD + + Sbjct: 131 EACGKRFPLPEAFAPPPFCPACGHRA--RPDVVWFGELLPEGAWERAERAFAEADFALVV 188 Query: 177 GTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFV 229 GTS V PAA A GA+ VE+N EP+ + A + + + Sbjct: 189 GTSAEVEPAASLGRIAFASGAYLVEVNPEPTPLTPLAHLSLRTGAVEGMALLL 241 >UniRef50_C1FAB6 Putative nicotinic acid mononucleotide:5, 6-dimethylbenzimidazole(DMB)phosphoribosyltransferase n=1 Tax=Acidobacterium capsulatum ATCC 51196 RepID=C1FAB6_ACIC5 Length = 250 Score = 275 bits (703), Expect = 1e-72, Method: Composition-based stats. Identities = 111/230 (48%), Positives = 143/230 (62%), Gaps = 3/230 (1%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 R+ VLTGAGISAESG+ TFR +DGLW +RVE+VATPEG+ +PELV FY+ RRR Sbjct: 13 SDRLFVLTGAGISAESGLATFRGSDGLWNGYRVEEVATPEGWAENPELVWRFYSMRRRDA 72 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG 122 E PNAAH+ALA+L++ +G+RF L TQN+D+LHERAG+ V HMHG L RC + Sbjct: 73 LAAE--PNAAHVALARLEERMGERFYLCTQNVDDLHERAGSRRVHHMHGTLFCSRCVRCQ 130 Query: 123 QVL-DWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGH 181 Q D T + C + + +RPH+VWFGE+P MD IY L A + + +GTSG Sbjct: 131 QPFADARFYETAGELPVCERCGSAVRPHIVWFGEIPRDMDGIYRELEQATVLLVVGTSGS 190 Query: 182 VYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEK 231 VYPAAG V A+ G TV + E F E G A +V+P + Sbjct: 191 VYPAAGLVQVARQRGIATVYVGPERPLNAQAFGEIRLGTAVEVLPGLFGE 240 >UniRef50_D2R126 Silent information regulator protein Sir2 n=1 Tax=Pirellula staleyi DSM 6068 RepID=D2R126_9PLAN Length = 256 Score = 271 bits (694), Expect = 1e-71, Method: Composition-based stats. Identities = 93/239 (38%), Positives = 131/239 (54%), Gaps = 8/239 (3%) Query: 3 KPRVLVLTGAGISAESGIRTFRAA-DGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 R++VLTGAGISAESG+ TFR A GLW R E++ATPE F+++P+LV +Y RR+ Sbjct: 21 AKRLVVLTGAGISAESGLATFRDAMTGLWANFRAEELATPEAFEQNPKLVWDWYVWRRKL 80 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 Q +PN AH AL +L+ + +VTQN+D LH+RAG+ VI +HG L + +CS Sbjct: 81 AQA--AKPNGAHFALVELERLVPQL-TIVTQNVDGLHQRAGSAGVIELHGSLSRFKCSTD 137 Query: 122 GQVLDWT--GDVTPEDKCHCCQFPAPLRPHVVWFGEM--PLGMDEIYMALSMADIFIAIG 177 + +D GD C + A +RP +VWFGEM P + + D+F +IG Sbjct: 138 NEPVDAKDFGDSPDGMPPRCPRCHAFVRPDIVWFGEMLPPSALQTAFQVTKKCDLFFSIG 197 Query: 178 TSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKGL 236 TSG V PAA A +GA + NL+ G A ++PE + + L Sbjct: 198 TSGVVEPAASLPRRAIEYGASVMINNLDVDTASEPPLYSLQGKAGTILPELLRRAWPRL 256 >UniRef50_Q8ZU41 NAD-dependent deacetylase 1 n=4 Tax=Pyrobaculum RepID=NPD1_PYRAE Length = 254 Score = 270 bits (691), Expect = 3e-71, Method: Composition-based stats. Identities = 79/235 (33%), Positives = 115/235 (48%), Gaps = 10/235 (4%) Query: 7 LVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQPE 66 + LTGAG+S SGI FR G+W E F +P+ V + + L Sbjct: 24 VALTGAGVSTASGIPDFRGPQGVWRRVDPEKFE-ISYFYNNPDEVWDLF--VKYLLPAFN 80 Query: 67 IQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVLD 126 ++PN AH ALA+++ LG ++TQN+D LH+ AG+ NVI +HG L C+ G Sbjct: 81 VKPNPAHYALAEMER-LGKLCAVITQNVDRLHQAAGSKNVIELHGALEYAVCTNCGSKYA 139 Query: 127 WTGD--VTPEDKCHCCQFPAPLRPHVVWFGEMPLGMD---EIYMALSMADIFIAIGTSGH 181 C + ++P VV+FGE PL D E +M MA++F+AIGTS Sbjct: 140 LAEALKWRKSGAPRCPKCGGVIKPDVVFFGE-PLPQDALREAFMLAEMAEVFMAIGTSLA 198 Query: 182 VYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKGL 236 VYPA AK GA V +N + + G A +V+P+ +++L L Sbjct: 199 VYPANQLPLVAKKRGAKLVIINADETYYDFFADYIIRGRAEEVLPKLLDRLRGML 253 >UniRef50_Q5L014 NAD-dependent deacetylase 1 n=8 Tax=Firmicutes RepID=NPD1_GEOKA Length = 242 Score = 270 bits (690), Expect = 4e-71, Method: Composition-based stats. Identities = 77/234 (32%), Positives = 111/234 (47%), Gaps = 10/234 (4%) Query: 3 KPRVLVLTGAGISAESGIRTFRAA-DGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 +VLTGAG+S ESG+ FR+ GLW ++AT + E FY R R Sbjct: 10 SRHTVVLTGAGMSTESGLPDFRSPRTGLWARFNPSELATIDALYHRRESFVEFYQYRIRT 69 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 LQ + QP+ H LA + G +VTQN+D H+ AG+ VI +HG L V C + Sbjct: 70 LQ--QCQPHDGHRLLADWERR-GIVQTIVTQNVDGFHQEAGSRRVIELHGSLRTVHCQRC 126 Query: 122 GQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPL--GMDEIYMALSMADIFIAIGTS 179 G+ C+ LRP VV FGE + E + A AD+F+ +G+S Sbjct: 127 GESKP---SFVYLHGVLTCECGGVLRPSVVLFGEPLPEKAITEAWEAAQQADLFLVLGSS 183 Query: 180 GHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYG-PASQVVPEFVEKL 232 V PA AK +GA V +N EP+++ + + +V+ E E+L Sbjct: 184 LQVSPANQLPLVAKRNGAKLVIINWEPTELDDLADAVIHQRKIGEVLNELNEQL 237 >UniRef50_B1LZ70 Silent information regulator protein Sir2 n=6 Tax=Alphaproteobacteria RepID=B1LZ70_METRJ Length = 237 Score = 269 bits (689), Expect = 5e-71, Method: Composition-based stats. Identities = 113/230 (49%), Positives = 147/230 (63%), Gaps = 5/230 (2%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQP 65 + VLTGAG+SAESG+ TFR G+W +ATPE + DP+ V FY+ RRR + Sbjct: 8 IFVLTGAGVSAESGLGTFRDRGGIWARFDPMKLATPEAYAADPDTVLDFYDHRRRGVVAA 67 Query: 66 EIQPNAAHLALAKLQ---DALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG 122 E PNAAH ALA+ + A G R L TQN+D+LHERAG+ + HMHGELLK RC Sbjct: 68 E--PNAAHRALARAETRIAARGGRLFLCTQNVDDLHERAGSRAITHMHGELLKARCCACT 125 Query: 123 QVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGHV 182 V W D++ D C C +RP VVWFGEMP+ +D I AL+ AD+F+A+GTSG V Sbjct: 126 AVTPWRADLSRADSCPACGAAGRMRPDVVWFGEMPMHLDAIEAALAEADLFVAVGTSGAV 185 Query: 183 YPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 YPAAG+V +A+ G T E+NLEPS + F + YGPAS +P ++ +L Sbjct: 186 YPAAGYVRQARALGIPTCEVNLEPSDNADAFDDARYGPASAALPRYLAEL 235 >UniRef50_B0SCR8 NAD-dependent protein deacetylase, SIR2 family n=2 Tax=Leptospira biflexa serovar Patoc RepID=B0SCR8_LEPBA Length = 251 Score = 269 bits (689), Expect = 5e-71, Method: Composition-based stats. Identities = 81/235 (34%), Positives = 125/235 (53%), Gaps = 6/235 (2%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 P ++ LTGAGIS+ESGI TFR GLW+ R ED+ATPE F ++P+LV +Y+ RR Sbjct: 15 APSIVFLTGAGISSESGIPTFRGEGGLWKNFRAEDLATPEAFQKNPKLVWEWYDWRREIC 74 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG 122 Q + +PN HL +AK Q L+TQN+D LH RAG+ +I +HG + +VRC+ Sbjct: 75 Q--KAKPNLGHLIIAKWQKKSSS-VHLITQNVDGLHPRAGSETLIELHGNIFRVRCTNCT 131 Query: 123 QVLDWTGDVTPEDKCHCCQ-FPAPLRPHVVWFGEMPLG--MDEIYMALSMADIFIAIGTS 179 + D C+ + LRP +VWFGE + + + + + I IGTS Sbjct: 132 SIFHLEKDGLDHPGLKFCKECDSLLRPDIVWFGEEYNQNLLTKSWELCKQSQVVILIGTS 191 Query: 180 GHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLK 234 +V A +GA +E+N E + + + G + +V+P+ +++ Sbjct: 192 ANVSVPTNLAQTAIRNGAIGIEINPEETNLTPSMKHHFDGKSGEVLPQIWKEVFP 246 >UniRef50_C9R9I3 Silent information regulator protein Sir2 n=1 Tax=Ammonifex degensii KC4 RepID=C9R9I3_AMMDK Length = 252 Score = 269 bits (689), Expect = 5e-71, Method: Composition-based stats. Identities = 78/245 (31%), Positives = 117/245 (47%), Gaps = 13/245 (5%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEGFDRDPELVQAFYNARR 59 ++ + TGAG+S ESGI FR+ GLW +AT E F DP F+ Sbjct: 14 LKAQKAYAFTGAGVSTESGIPDFRSPGTGLWSNPEALALATGEAFLHDPARFYRFFLPMW 73 Query: 60 RQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCS 119 + + QPN AH ALA+L+ +G +VTQNID LH +AG+ V +HG L + C+ Sbjct: 74 QNYR--RAQPNPAHRALAELE-KMGILRGVVTQNIDGLHRKAGSQVVWEVHGNLENLVCT 130 Query: 120 QSGQVLDWT---GDVTPEDKCHCCQFPAPLRPHVVWFGE-MPLGMDEIYMALSM-ADIFI 174 + + ++ +D C LRP+VV FGE M + L D+ + Sbjct: 131 RCRRAAPFSLAEEAWAKDDLPPRCGCGGILRPNVVLFGEPMTPDFHRAAIFLRQGCDLLL 190 Query: 175 AIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLK 234 +G+S VYPAA V A+ + +N EP+ + A G A ++P+ VE + Sbjct: 191 VVGSSLTVYPAASLVDYARQ----LIIVNREPTPADDRAAVVLRGQAGIILPKIVEAVKA 246 Query: 235 GLKAG 239 + G Sbjct: 247 HQRLG 251 >UniRef50_Q1QDL3 Silent information regulator protein Sir2 n=6 Tax=Bacteria RepID=Q1QDL3_PSYCK Length = 266 Score = 269 bits (688), Expect = 6e-71, Method: Composition-based stats. Identities = 97/245 (39%), Positives = 136/245 (55%), Gaps = 19/245 (7%) Query: 3 KPRVLVLTGAGISAESGIRTFRAA-DGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 K + +LTGAGISAESGI TFR GLWE +R ED+ATP+ F RDP+LV ++Y RR+ Sbjct: 23 KQHICLLTGAGISAESGIPTFRDKQTGLWENYRAEDLATPDAFARDPKLVWSWYQWRRQL 82 Query: 62 LQQPEIQPNAAHLALAKLQ---DALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRC 118 + +PN AH ALA+ Q + + L+TQN+D+LHE+AG+ V H+HG L + RC Sbjct: 83 VASK--KPNPAHTALAQWQYHSQSTNQQLTLITQNVDDLHEQAGSA-VTHLHGNLWRNRC 139 Query: 119 SQS--------GQVLDWTGDVTPEDKCHCCQ-FPAPLRPHVVWFGEMPL--GMDEIYMAL 167 SQ D ++ ++ CQ +RP +VWFGE A Sbjct: 140 SQCQTPYTIQLKSAYDSENSISFDEALMTCQHCDGYIRPDIVWFGESLPMRAWQTAEEAA 199 Query: 168 SMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPE 227 + D+FI+IGTS VYPAAG AK +GA +E+N P+ A ++PE Sbjct: 200 ANCDVFISIGTSSLVYPAAGLAQLAKHNGAKIIEINPYPTPNT-LVDITLAAKAGAILPE 258 Query: 228 FVEKL 232 V+++ Sbjct: 259 LVKRM 263 >UniRef50_A7XXV9 Sirtuin 5 n=14 Tax=Eumetazoa RepID=A7XXV9_PIG Length = 310 Score = 269 bits (688), Expect = 6e-71, Method: Composition-based stats. Identities = 94/257 (36%), Positives = 136/257 (52%), Gaps = 29/257 (11%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 + ++V++GAG+SAESGI TFR A G W + + +D+ATP+ F R+P V FY+ RR Sbjct: 49 KAKHIVVISGAGVSAESGIPTFRGAGGYWRKWQAQDLATPQAFARNPSRVWEFYHHRREV 108 Query: 62 LQQPEIQPNAAHLALAKLQDAL---GDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRC 118 +Q PNA HLA+A+ + L G R +++TQNID LH +AG N++ +HG L K RC Sbjct: 109 VQGR--APNAGHLAIAQCEARLHGQGRRLVVITQNIDELHRKAGTRNLLEIHGSLFKTRC 166 Query: 119 SQSGQVLD---------WTGDVTPE-------------DKCHCCQFPAPLRPHVVWFGEM 156 + G V + +G PE +C LRPHVVWFGE Sbjct: 167 TSCGAVAENYKSPICPALSGKGAPEPETQDARIPVEKLPRCEEAGCGGLLRPHVVWFGEN 226 Query: 157 --PLGMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFA 214 P ++E+ L++ D+ + +GTS VYPAA F + G E N+E + N F Sbjct: 227 LDPAILEEVDRELALCDLCLVVGTSSVVYPAALFAPQVSARGVPVAEFNVEATPATNRFR 286 Query: 215 EKYYGPASQVVPEFVEK 231 + GP +PE + Sbjct: 287 FHFQGPCGTTLPEALAP 303 >UniRef50_C7FPB6 NAD-dependent protein deacetylase n=4 Tax=environmental samples RepID=C7FPB6_9BACT Length = 247 Score = 268 bits (687), Expect = 9e-71, Method: Composition-based stats. Identities = 82/233 (35%), Positives = 124/233 (53%), Gaps = 6/233 (2%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 RV V++GAGISAESGI TFR + GLWE R E++ATP+ F DPE V +Y R Q Sbjct: 16 AERVFVVSGAGISAESGIPTFRGSGGLWEGFRAEELATPQAFAADPERVWRWYRWRAEQY 75 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG 122 + PNA H +A + R L+ TQN+D LH RAG+ V+ +HG + +RC+ Sbjct: 76 --GDCAPNAGHDTIAAMASRY-RRLLVATQNVDGLHRRAGSPAVVELHGSIADMRCTACD 132 Query: 123 QVLDWTGDVTPEDKCHCCQ-FPAPLRPHVVWFGEM--PLGMDEIYMALSMADIFIAIGTS 179 + + D C +RPH++WFGE P ++ A AD+ + +GTS Sbjct: 133 TLAPFPRGTEDSDPVPRCALCGERMRPHILWFGETYWPGILERAQQAAEEADVCLVVGTS 192 Query: 180 GHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 V+P A+ GA +++N E +++ GP+ +++PE E++ Sbjct: 193 AQVWPPVALALHAQASGAFLIDINPEATELSGRADAHLAGPSGRLLPELWERV 245 >UniRef50_Q46ZJ9 Silent information regulator protein Sir2 n=4 Tax=Bacteria RepID=Q46ZJ9_RALEJ Length = 260 Score = 267 bits (684), Expect = 2e-70, Method: Composition-based stats. Identities = 91/232 (39%), Positives = 118/232 (50%), Gaps = 10/232 (4%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAA-DGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 + V VLTGAGISAESG+ TFR A GLW E++A+ E + R P LV +Y RR Sbjct: 25 QARSVFVLTGAGISAESGVPTFRDALTGLWARFDPEELASEEAYRRQPALVWEWYQHRRD 84 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 + +PN AH AL L A LVTQN+D LH+RAG+ +VI +HG L + Sbjct: 85 LVAA--ARPNPAHYALVAL--AAQKTVTLVTQNVDGLHQRAGSDHVIELHGNLFANKWLN 140 Query: 121 -SGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGM--DEIYMALSMADIFIAIG 177 G+ + T P D C A +RP VVWFGE + A AD+ + +G Sbjct: 141 GCGRCDEATA--IPGDPPRCSLCGALMRPGVVWFGEDLPRVARFRAEHAAETADLCLVVG 198 Query: 178 TSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFV 229 TSG VYPAAG A+ HGA V +N +PS + A +P Sbjct: 199 TSGLVYPAAGLPGLARDHGARVVVVNPQPSVLDQTADVVLQAAAGASLPLLW 250 >UniRef50_A6LP94 Silent information regulator protein Sir2 n=1 Tax=Thermosipho melanesiensis BI429 RepID=A6LP94_THEM4 Length = 234 Score = 266 bits (682), Expect = 3e-70, Method: Composition-based stats. Identities = 74/240 (30%), Positives = 123/240 (51%), Gaps = 17/240 (7%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 +E+ V+ LTGAGIS SGI FR+ DGL++E+ ++ + E F P++ FY ++ Sbjct: 9 LEEGNVVALTGAGISTSSGIPDFRSEDGLYKEYG-YELFSYEFFKNHPDI---FYEYIKK 64 Query: 61 QLQQ-PEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCS 119 + + + N +H LA+L++ +G ++TQNID+LH +AG+ NVI +HG C Sbjct: 65 EFPKMYKANYNMSHKLLAELEE-MGYLLGVITQNIDDLHNKAGSRNVIELHGNATHFYCE 123 Query: 120 QSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTS 179 + + + + C +RP +V+FGE +D ++ L A+ + +GTS Sbjct: 124 ECERKYSFPKEYI-------CSCGGLIRPDIVFFGEPVNDIDRVFELLDKAETLLVMGTS 176 Query: 180 GHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKGLKAG 239 VYPA+ F K G + +N E +Q N + V EF +K+LK + Sbjct: 177 LQVYPASNFPVYVKERGGILIIVNREETQYDNFADFVLHMN----VEEFSKKVLKYFEEE 232 >UniRef50_Q9NXA8 NAD-dependent deacetylase sirtuin-5 n=37 Tax=Metazoa RepID=SIRT5_HUMAN Length = 310 Score = 266 bits (681), Expect = 4e-70, Method: Composition-based stats. Identities = 90/256 (35%), Positives = 131/256 (51%), Gaps = 29/256 (11%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 + +++++GAG+SAESG+ TFR A G W + + +D+ATP F +P V FY+ RR Sbjct: 49 KAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQDLATPLAFAHNPSRVWEFYHYRREV 108 Query: 62 LQQPEIQPNAAHLALAKLQDALGD---RFLLVTQNIDNLHERAGNTNVIHMHGELLKVRC 118 + E PNA H A+A+ + LG R +++TQNID LH +AG N++ +HG L K RC Sbjct: 109 MGSKE--PNAGHRAIAECETRLGKQGRRVVVITQNIDELHRKAGTKNLLEIHGSLFKTRC 166 Query: 119 SQSGQVLD---------WTGDVTPE-------------DKCHCCQFPAPLRPHVVWFGEM 156 + G V + +G PE +C LRPHVVWFGE Sbjct: 167 TSCGVVAENYKSPICPALSGKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGEN 226 Query: 157 --PLGMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFA 214 P ++E+ L+ D+ + +GTS VYPAA F + G E N E + N F Sbjct: 227 LDPAILEEVDRELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTPATNRFR 286 Query: 215 EKYYGPASQVVPEFVE 230 + GP +PE + Sbjct: 287 FHFQGPCGTTLPEALA 302 >UniRef50_Q8F3Z6 NAD-dependent deacetylase n=4 Tax=Leptospira RepID=NPD_LEPIN Length = 246 Score = 266 bits (681), Expect = 4e-70, Method: Composition-based stats. Identities = 82/233 (35%), Positives = 123/233 (52%), Gaps = 6/233 (2%) Query: 4 PRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQ 63 ++ ++GAGISAESGI TFR ++GLW+ R ED+ATP+ F ++P+LV +Y RR ++ Sbjct: 13 QKISAISGAGISAESGIPTFRGSEGLWKNFRAEDLATPQAFSKNPKLVWEWYLWRRNIIE 72 Query: 64 QPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQ 123 +PN H AL +L+ D F L+TQN+D LH +AG+ + +HG + RC GQ Sbjct: 73 TK--RPNPGHFALVELERIHPD-FFLITQNVDGLHSQAGSKKLTEIHGNIFINRCISCGQ 129 Query: 124 V-LDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGM--DEIYMALSMADIFIAIGTSG 180 + + T C + LRP VVWFGE + + D+ + +GTSG Sbjct: 130 ESKETISENTTPLPPQCQNCNSFLRPGVVWFGESYDDFKLNLSIQRMKHTDLLLVLGTSG 189 Query: 181 HVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLL 233 V AK GA +E+N E S + G +V+PE + ++L Sbjct: 190 SVSMPVYLAQIAKDSGALLIEINPERSSFSSSVDLFLQGKTGEVLPELIREIL 242 >UniRef50_P66814 NAD-dependent deacetylase n=12 Tax=Mycobacterium tuberculosis complex RepID=NPD_MYCBO Length = 237 Score = 266 bits (680), Expect = 5e-70, Method: Composition-based stats. Identities = 89/241 (36%), Positives = 128/241 (53%), Gaps = 13/241 (5%) Query: 5 RVLVLTGAGISAESGIRTFRA-ADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQ 63 RV VL+GAGISAESG+ TFR +GLW ++++ +G+ R+PE V +Y R + Sbjct: 2 RVAVLSGAGISAESGVPTFRDDKNGLWARFDPYELSSTQGWLRNPERVWGWYLWRHYLV- 60 Query: 64 QPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQ 123 ++PN H A+A QD ++TQN+D+LHERAG+ V H+HG L + RC++ G Sbjct: 61 -ANVEPNDGHRAIAAWQDHA--EVSVITQNVDDLHERAGSGAVHHLHGSLFEFRCARCGV 117 Query: 124 VLDWTGDVTPED----KCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSM---ADIFIAI 176 PE + C +RP +VWFGE PL + A+ AD+ + + Sbjct: 118 PYTDALPEMPEPAIEVEPPVCDCGGLIRPDIVWFGE-PLPEEPWRSAVEATGSADVMVVV 176 Query: 177 GTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKGL 236 GTS VYPAAG A G +E+N EP+ + ASQ +P +E+L L Sbjct: 177 GTSAIVYPAAGLPDLALARGTAVIEVNPEPTPLSGSATISIRESASQALPGLLERLPALL 236 Query: 237 K 237 K Sbjct: 237 K 237 >UniRef50_C1XSL0 NAD-dependent protein deacetylase, SIR2 family n=1 Tax=Meiothermus silvanus DSM 9946 RepID=C1XSL0_9DEIN Length = 265 Score = 266 bits (680), Expect = 6e-70, Method: Composition-based stats. Identities = 87/247 (35%), Positives = 121/247 (48%), Gaps = 21/247 (8%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 E RV VLTGAGISA SGI TFR A GLW++ R+ED ATPE + RDP V +Y R Sbjct: 12 EAKRVAVLTGAGISAPSGIPTFRDAGGLWKDFRIEDYATPEAYRRDPLKVWEWYAWR--Y 69 Query: 62 LQQPEIQPNAAHLALAKLQD-----------------ALGDRFLLVTQNIDNLHERAGNT 104 + QPN AH LA+L+ G FLLVTQN+D LH RAG+T Sbjct: 70 ANAMQAQPNRAHRLLAELERQFTTPSPHVGDRLTPTAREGSGFLLVTQNVDGLHARAGST 129 Query: 105 NVIHMHGELLKVRCSQSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEM--PLGMDE 162 +++ +HG + + RC + G C + RP VVWFGE+ P + Sbjct: 130 HLVELHGSIGRARCEECGARFPLPDPGLFIPPPVCPKCGGRGRPDVVWFGELLPPGAFER 189 Query: 163 IYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPAS 222 A + A++ + +GTS + PAA A GA+ +E+N + + A Sbjct: 190 AENAFAKAEVALVVGTSAEIEPAASLGRLASWAGAYLIEINPNQTPLSRLADCSLRMGAI 249 Query: 223 QVVPEFV 229 + + + Sbjct: 250 EGLEALL 256 >UniRef50_Q2LSF2 Sir2 family of NAD+-dependent deacetylase n=2 Tax=Syntrophus aciditrophicus SB RepID=Q2LSF2_SYNAS Length = 271 Score = 264 bits (676), Expect = 2e-69, Method: Composition-based stats. Identities = 76/249 (30%), Positives = 119/249 (47%), Gaps = 14/249 (5%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 RV+V TGAG+S ESGI FR+ GLW+ +D T F R + + + Sbjct: 25 AGRVVVFTGAGVSTESGIPDFRSPGGLWDRFDPDDF-TIGKFLRSAQTRRKQWRILIAGG 83 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGN--TNVIHMHGELLKVRCSQ 120 E QPN AHLA+A+L+ +G ++TQNIDNLH++AGN V +HG + ++C Sbjct: 84 ALAEAQPNRAHLAVAELE-KIGKLNCVITQNIDNLHQKAGNAPEKVYELHGNMRWLKCLS 142 Query: 121 SG------QVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMADI 172 G ++ T + C + ++P V++FGE + + D+ Sbjct: 143 CGDRVSVPEMFRETALQEMDGFPFCAKCQGLMKPDVIFFGEALPEKTLRDATWQARNCDL 202 Query: 173 FIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 + IG+S VYPAA AK GA V +N + + +E G A +++ ++ + Sbjct: 203 LLVIGSSLVVYPAAYMPMYAKDAGARLVIINRDETPYDSEADVLLQGSAGEIMSRILDAV 262 Query: 233 LK--GLKAG 239 G K G Sbjct: 263 KHRTGFKPG 271 >UniRef50_B5Y820 Putative NAD-dependent deacetylase 2 n=1 Tax=Coprothermobacter proteolyticus DSM 5265 RepID=B5Y820_COPPD Length = 245 Score = 263 bits (672), Expect = 4e-69, Method: Composition-based stats. Identities = 69/233 (29%), Positives = 104/233 (44%), Gaps = 10/233 (4%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 +VLTGAGIS ESGI +R GLW ++ + F+ DP+ F + Sbjct: 15 SGHAVVLTGAGISTESGIPDYRGPQGLWRKYDPIKYVSRSTFETDPKTFWEF--NLPMWM 72 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG 122 Q +PN AH +A+L+ LG ++TQNID LH+RAG+ NV +HG L V C + Sbjct: 73 QYKAAKPNKAHFLVAELER-LGFIKAVITQNIDGLHKRAGSKNVYEVHGNLETVTCLRCH 131 Query: 123 QVLDWTGDVTPEDKC--HCCQFPAPLRPHVVWF-GEMPLGMDEIYMALSMADIFIAIGTS 179 + + C C LRP+VV F MP + + +D+ I +G+S Sbjct: 132 KEYPLEEAWKQFNDCNIPQCSCGGLLRPNVVLFEDPMPDTFFQAVREVESSDLMIVMGSS 191 Query: 180 GHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 VYP A + V +NL P+ + ++ + + L Sbjct: 192 LEVYPVAQLPAMV----SKLVVVNLLPTPYDDRADYVFHESTGEFSEKLASVL 240 >UniRef50_UPI000186E50A snf2 histone linker PHD ring helicase, putative n=2 Tax=Coelomata RepID=UPI000186E50A Length = 1709 Score = 263 bits (672), Expect = 5e-69, Method: Composition-based stats. Identities = 87/238 (36%), Positives = 124/238 (52%), Gaps = 29/238 (12%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 +L+LTGAG+SAESGI TFR G W +++ +++ATPE F +P LV FY+ RR Sbjct: 1473 SKNLLILTGAGVSAESGIPTFRGPGGYWRKYQAQNLATPEAFRANPSLVWEFYHHRRETA 1532 Query: 63 QQPEIQPNAAHLALAKLQD---ALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCS 119 E PN AH A+A+ Q+ G + ++TQNID LH+RAG ++VI +HG L K RC Sbjct: 1533 LTKE--PNNAHKAIAECQNRFAKEGKKVWIITQNIDELHKRAGASDVIELHGSLFKTRCL 1590 Query: 120 QSGQV-----------LDWTGDVTPE-----------DKCHCCQFPAPLRPHVVWFGEM- 156 + ++ LD G P +C LRPH+VWFGE Sbjct: 1591 KCKEIRENYDSPVCSALDGKGAPDPCAESADIPEKLLPRCKKENCGGLLRPHIVWFGENL 1650 Query: 157 -PLGMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEF 213 P ++ A++ D+ + +GTS VYPAA F + G E N+E + +F Sbjct: 1651 DPKVLELTEKAVNECDLCLVVGTSSVVYPAAMFAPQVAYRGVSVAEFNIESTPATGDF 1708 >UniRef50_B0EU66 NAD-dependent deacetylase, putative n=2 Tax=Entamoeba RepID=B0EU66_ENTDI Length = 344 Score = 262 bits (670), Expect = 8e-69, Method: Composition-based stats. Identities = 72/246 (29%), Positives = 109/246 (44%), Gaps = 13/246 (5%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 + V VLTGAGIS ESGI FR+++GLW+ + + F + PEL + Sbjct: 34 KSKNVTVLTGAGISVESGIPDFRSSNGLWKRYDPSVYGSYSNFKKHPELFWK----MTEE 89 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 + + PN H ALA+L+ +G +VTQN+D LH++AG+ NV+ MHG C Sbjct: 90 IHKITAYPNHVHEALAELE-KIGVVKTIVTQNVDGLHQQAGSKNVVEMHGSGRACYCIDC 148 Query: 122 GQVLDWTGDVTPEDKCH------CCQFPAPLRPHVVWFGEMPLGM--DEIYMALSMADIF 173 + D+ + C + L+ VV FGE + DE+ A + D Sbjct: 149 DYISRADNDIWSKPVPPSQCIPRCPKCGGLLKLDVVLFGEKLDRVTYDEVVEASTKTDFL 208 Query: 174 IAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLL 233 + IGTS V P AK GA +N + + G ++VP K+ Sbjct: 209 LVIGTSLQVAPCNIIPFRAKHCGAQVAFINCSKTPMDEYADFVVRGDLKEIVPRIANKIK 268 Query: 234 KGLKAG 239 + + Sbjct: 269 EIREKR 274 >UniRef50_C8QW70 Silent information regulator protein Sir2 n=1 Tax=Desulfurivibrio alkaliphilus AHT2 RepID=C8QW70_9DELT Length = 265 Score = 262 bits (670), Expect = 9e-69, Method: Composition-based stats. Identities = 85/237 (35%), Positives = 122/237 (51%), Gaps = 7/237 (2%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQP 65 L LTGAGIS ESGI FR+A GLW + AT E F +DP V R L + Sbjct: 18 TLALTGAGISVESGIPDFRSAGGLWARFNPAEYATIEAFRQDPHKVWRMLAEMDRLLVRS 77 Query: 66 EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVL 125 +PN AHL LA+L+ LG ++TQN+DNLH+ G+ VI HG + C V Sbjct: 78 --RPNPAHLGLAELER-LGYLQFVITQNVDNLHQAGGSQRVIEFHGNAATLACLACHAVY 134 Query: 126 DWTGDVTPEDKCHCCQFPAPLRPHVVWFGE--MPLGMDEIYMALSMADIFIAIGTSGHVY 183 +V+ + C L+P V++FGE P + + + +S+A + + IGTS V Sbjct: 135 SR-AEVSNQAVPPKCVCGQVLKPEVIFFGEEIPPPVLAQAHDLVSLARVLLVIGTSAEVA 193 Query: 184 PAAGFVHEAKLHGAHTVELNLEPSQVGNEF-AEKYYGPASQVVPEFVEKLLKGLKAG 239 PA+ AK HGA VE+N E +++ +E G A +++P V +L + G Sbjct: 194 PASMLPRLAKEHGATIVEINPEKTRLTDELTDILLQGRAGEIIPALVAELKRRTTDG 250 >UniRef50_A4J646 Silent information regulator protein Sir2 n=2 Tax=Peptococcaceae RepID=A4J646_DESRM Length = 256 Score = 261 bits (669), Expect = 9e-69, Method: Composition-based stats. Identities = 76/234 (32%), Positives = 116/234 (49%), Gaps = 14/234 (5%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 + + + LTGAGIS ESGI FR+ + GLW ++ ++VA+ + ++PE +FY + Sbjct: 16 KAGKTIALTGAGISTESGIPDFRSKNTGLWNQYDPQEVASIQALKKNPE---SFYALNFQ 72 Query: 61 QLQQ-PEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCS 119 + +PN AH ALA+L+ +G ++TQNID LH+ AG+ V +HG L C Sbjct: 73 WWDVCLKAKPNNAHFALARLE-KMGWLLGVITQNIDGLHQHAGSKRVWEVHGNLKGCSCL 131 Query: 120 QSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGE-MPLGMDEIYMALSMADIFIAIGT 178 + D C LRP VV FG+ MP +S + + IG+ Sbjct: 132 SCKKQFDMGQLHKQ---LRCPFCGGLLRPDVVLFGDAMPEDFFMAEKVMSGCQLLLVIGS 188 Query: 179 SGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 S VYP A + + TV +N EP+ ++ PASQV+ + V+ L Sbjct: 189 SLQVYPVASLPQLS----SKTVIINKEPTTWDKHSDVVFHEPASQVLCDLVDSL 238 >UniRef50_B1MER1 NAD-dependent deacetylase (Regulatory protein Sir2 homolog) n=4 Tax=Mycobacterium RepID=B1MER1_MYCA9 Length = 248 Score = 260 bits (666), Expect = 3e-68, Method: Composition-based stats. Identities = 88/222 (39%), Positives = 119/222 (53%), Gaps = 9/222 (4%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAA-DGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 + V VLTGAG+SAESG+ TFR A GLW ++ +ATPE + DP LV A+Y RR Sbjct: 14 KARSVTVLTGAGMSAESGLPTFRDAQTGLWSKYDPMTLATPESWQEDPGLVWAWYQNRRI 73 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 QL +QPN H ALA+ +VTQN+D+LHERAG++NV H+HG LLK C Sbjct: 74 QLLA--VQPNDGHRALAQWGSH--RDIRIVTQNVDDLHERAGSSNVTHVHGSLLKSHCDT 129 Query: 121 SGQVLDWTGDVTPEDK--CHCCQFPAPLRPHVVWFGEMPLGMD--EIYMALSMADIFIAI 176 + T ++ C +RP +VWFGEM ++ D+ + I Sbjct: 130 CRSDFEATVSAPEAERVAPPECGCGGKVRPSIVWFGEMLPEVEFGHAVAHSQNCDLMLLI 189 Query: 177 GTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYY 218 GTSG VYPAAG A GA VE+N + + + + + Sbjct: 190 GTSGIVYPAAGLPQLALSRGATVVEINPQETDLSDRADLVWR 231 >UniRef50_Q1D737 NAD-dependent deacetylase n=1 Tax=Myxococcus xanthus DK 1622 RepID=Q1D737_MYXXD Length = 245 Score = 260 bits (665), Expect = 3e-68, Method: Composition-based stats. Identities = 104/234 (44%), Positives = 135/234 (57%), Gaps = 11/234 (4%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQP 65 +LVLTGAG+SAESG+ TFR GLWE+ VE VA+PEGF +DP LV FY+ RR+ Sbjct: 12 LLVLTGAGVSAESGVPTFRGMSGLWEDQPVEAVASPEGFRKDPALVWRFYSERRK--AAA 69 Query: 66 EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVL 125 + PN H AL + LGDRFLL TQN+D LH RAG+ V+ MHG L K RCS+ G+ Sbjct: 70 AVHPNPGHEALVAWERHLGDRFLLATQNVDGLHTRAGSQRVVEMHGNLFKTRCSRCGRPP 129 Query: 126 DWTGDVTPEDKCHCCQ-FPAPLRPHVVWFGEM--PLGMDEIYM-ALSMAD-----IFIAI 176 V P C LRPH+VWFGE P + I +L A +F+A Sbjct: 130 FEDATVYPAGAVPECDACGKLLRPHIVWFGEYLDPADIQRIEDFSLRAATSGGRFVFLAA 189 Query: 177 GTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVE 230 GTSG VYPAAG V + + G T +NL+P++ N F + + +V+P + Sbjct: 190 GTSGAVYPAAGIVDQVRKAGGKTWLVNLDPAENSNRFEHRIVDKSGEVLPTLAK 243 >UniRef50_Q8Y015 NAD-dependent deacetylase n=20 Tax=cellular organisms RepID=NPD_RALSO Length = 246 Score = 260 bits (664), Expect = 4e-68, Method: Composition-based stats. Identities = 92/232 (39%), Positives = 122/232 (52%), Gaps = 10/232 (4%) Query: 3 KPRVLVLTGAGISAESGIRTFRAA-DGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 RV+VLTGAG+SAESG+ TFR A GLW ED+AT + P +V +Y RR + Sbjct: 21 AERVMVLTGAGVSAESGVPTFRDALTGLWARFNPEDLATEAAYREHPRMVWDWYQERRAR 80 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ- 120 + ++QPN AHLA+A L LVTQN+D LH+RAG+ VI +HG L + Sbjct: 81 V--SQVQPNPAHLAIAALATR--KTVALVTQNVDGLHQRAGSVGVIELHGNLFANKWLDG 136 Query: 121 SGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMD--EIYMALSMADIFIAIGT 178 G+ T + P C A LRP VVWFGE + A + D+ + +GT Sbjct: 137 CGKCDVATAE--PGRPPRCAACGAMLRPGVVWFGERLPVVANYRAEEAANTCDVCLVVGT 194 Query: 179 SGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVE 230 SG VYPAAG AK HGA + +N EPS + + PA +P + Sbjct: 195 SGMVYPAAGLPGLAKDHGARVIVVNPEPSVLDETADLVIHQPAGVCLPAMLA 246 >UniRef50_Q2YZT2 Putative uncharacterized protein n=1 Tax=uncultured delta proteobacterium RepID=Q2YZT2_9DELT Length = 254 Score = 258 bits (659), Expect = 1e-67, Method: Composition-based stats. Identities = 78/235 (33%), Positives = 118/235 (50%), Gaps = 7/235 (2%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 ++ V+ +TGAGIS ESGI FR+ GLW + A + F RDP V Sbjct: 13 IKSKYVIAMTGAGISVESGIPDFRSPGGLWSRFDPFEYAHIDAFKRDPAKVWKMLLEIDE 72 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 L + +PN AH ALAKL+ A G ++TQNIDN+H+RAG+ NVI HG + C++ Sbjct: 73 VLN--QAKPNRAHYALAKLE-AAGILKAIITQNIDNMHQRAGSKNVIEFHGNAETLTCTK 129 Query: 121 SGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGE-MPLGMDEIY-MALSMADIFIAIGT 178 + ++T E C+ +RP VV+FGE +P + + + + IGT Sbjct: 130 CKKKFTR-EEITMESIPPLCECKGVIRPDVVFFGETIPAHATRMAGKEVEKCAMILVIGT 188 Query: 179 SGHVYPAAGFVHEAKLHGAHTVELNLEPSQV-GNEFAEKYYGPASQVVPEFVEKL 232 S V PA+ +AK GA VE+NL +++ + A + + V ++ Sbjct: 189 SADVAPASRLPIKAKEGGAIIVEINLRETRLITPIADFRITDKAGDGLMKLVNEV 243 >UniRef50_D2QCS2 Silent information regulator protein Sir2 n=29 Tax=Bacteria RepID=D2QCS2_9SPHI Length = 235 Score = 257 bits (658), Expect = 2e-67, Method: Composition-based stats. Identities = 102/234 (43%), Positives = 143/234 (61%), Gaps = 7/234 (2%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 + +++VL+GAGISAESGI TFRA+DGLWE HR+EDVATPE + R+P LVQ FYN RR+Q Sbjct: 4 RKKIVVLSGAGISAESGIPTFRASDGLWENHRIEDVATPEAWHRNPALVQDFYNQRRKQA 63 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG 122 +QPNA HLAL KL++ ++TQN+DNLHE+AG++ V+H+HGEL K R + Sbjct: 64 LS--VQPNAGHLALVKLEEKF--DVTVITQNVDNLHEKAGSSKVVHLHGELFKSRSTVDE 119 Query: 123 QVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGHV 182 ++ +D C + + LRPH+VWFGE MD AD+FI +GTS +V Sbjct: 120 SLIYDIEGWELKDGDVCAK-GSQLRPHIVWFGEAVPMMDIALDITEQADLFIVVGTSLNV 178 Query: 183 YPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYG-PASQVVPEFVEKLLKG 235 YPAAG V A G ++ + + + PA+ + + E+L+ Sbjct: 179 YPAAGLV-YAVREGVPVYVVDPSIPDMHKKNNVTFIAEPATIGLTQLAEQLIAE 231 >UniRef50_A8VRI8 NAD-dependent protein deacetylase SIR2 family-like protein n=1 Tax=Bacillus selenitireducens MLS10 RepID=A8VRI8_9BACI Length = 235 Score = 256 bits (654), Expect = 5e-67, Method: Composition-based stats. Identities = 79/235 (33%), Positives = 119/235 (50%), Gaps = 12/235 (5%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 V+VLTGAG+S ES I FR+ G W++ +ATPE + +PE +AFY AR L Sbjct: 11 ADSVVVLTGAGMSTESNIPDFRSRSGWWQQVDPMTIATPEALEGNPEQFKAFYKARLEAL 70 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG 122 + E +PN H +A+ ++ G + TQN+D LH+RAG+ NV +HG + +RC + Sbjct: 71 E--EAEPNRGHQIIARWEER-GLVDRVATQNVDGLHQRAGSRNVDALHGTIHAIRCHRCD 127 Query: 123 QVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPL--GMDEIYMALSMADIFIAIGTSG 180 + + + E C LRP VV FGEM A+ AD+ + IGTS Sbjct: 128 RPHELDAFLRDE---ACVSCGGVLRPGVVLFGEMLPQDAWQRALKAIEKADVVLVIGTSL 184 Query: 181 HVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKG 235 VYP G TV +N + Q + F + G A +++ E ++L++ Sbjct: 185 DVYPVNQLPSVT---GGKTVYINRDIDQSIHAFDAVHQGSAGEILEEL-DRLMEA 235 >UniRef50_C0GT54 Silent information regulator protein Sir2 n=1 Tax=Desulfonatronospira thiodismutans ASO3-1 RepID=C0GT54_9DELT Length = 249 Score = 256 bits (654), Expect = 5e-67, Method: Composition-based stats. Identities = 76/231 (32%), Positives = 108/231 (46%), Gaps = 8/231 (3%) Query: 7 LVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQPE 66 L LTGAGIS SGI FR+ GLW + + VA+ + +P V F + Sbjct: 22 LALTGAGISVASGIPDFRSPGGLWSRYDPQAVASDWALENNPRQVWEFLLEAVGMIAA-- 79 Query: 67 IQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVLD 126 +PN AH +LA+++D +G ++TQNIDNLH+RAG+ VI HG C + + + Sbjct: 80 AKPNPAHESLARMED-MGYLKAVITQNIDNLHQRAGSRKVIEFHGGAGTFYCHKCKKKYN 138 Query: 127 ---WTGDVTPEDKCHCCQFPAPLRPHVVWFGEM--PLGMDEIYMALSMADIFIAIGTSGH 181 + C Q +RP VV+FGE + E + AD+ + GTSG Sbjct: 139 QQKALELTRKDIPWLCSQCYGVVRPGVVFFGEQIPEQALQETRRLVLAADLVLVAGTSGD 198 Query: 182 VYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 V PA K G +E+NL + N + PA +P VE L Sbjct: 199 VAPAGTLPRWVKEQGGRVIEVNLGRTSFQNISDIRLDEPAETALPRIVEAL 249 >UniRef50_B3EMB2 Silent information regulator protein Sir2 n=2 Tax=Chlorobiaceae RepID=B3EMB2_CHLPB Length = 230 Score = 255 bits (653), Expect = 8e-67, Method: Composition-based stats. Identities = 86/228 (37%), Positives = 131/228 (57%), Gaps = 13/228 (5%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQP 65 ++ TGAG+SAESG+ T+R G+W + +++ A E FDR+PE V F+ RR+ + Sbjct: 13 IVFFTGAGMSAESGVPTYRGKGGIWGSYSIDEYACQEAFDRNPEKVLGFHEKRRKSVL-- 70 Query: 66 EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVL 125 + QP+ H +A L +A +VTQNID +H+RAG+ +VI +HG L ++RC G Sbjct: 71 DCQPHEGHSVVAVLPNAK-----VVTQNIDGMHQRAGSKDVIELHGSLWRLRCQSCGFRK 125 Query: 126 DWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMADIFIAIGTSGHVY 183 + + + C LRP ++WFG+M M + A+ D+F++IGTSG V+ Sbjct: 126 EDLAESYETTR---CDCGDRLRPDIIWFGDMLDAVVMSKASQAIRNCDLFVSIGTSGTVW 182 Query: 184 PAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEK 231 PAAGF AK GA+ +E+N EPS E+ G A +V+PE + Sbjct: 183 PAAGFPDLAKQSGAYCIEINPEPSGAS-EYDRVIVGNAGEVLPELFSE 229 >UniRef50_B7IF48 NAD-dependent deacetylase n=1 Tax=Thermosipho africanus TCF52B RepID=B7IF48_THEAB Length = 235 Score = 255 bits (652), Expect = 1e-66, Method: Composition-based stats. Identities = 67/231 (29%), Positives = 115/231 (49%), Gaps = 10/231 (4%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 ++ ++VLTGAGIS +SGI FR+ DGL++++ E + + F +P + F + Sbjct: 9 IKNGNIVVLTGAGISTKSGIPDFRSKDGLYQKYG-EKIFDLQFFFENPSVFYDF--VYKE 65 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 + + +PN AH+ LAKL+ G ++TQNIDNLH +AG+ NV+ +HG + C++ Sbjct: 66 FPKMYDAKPNFAHIFLAKLE-KNGYINGIITQNIDNLHYKAGSKNVLELHGNATRFYCTK 124 Query: 121 SGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSG 180 G+ T D + C+ +RP +V+F E ++E Y + + I +G+S Sbjct: 125 CGKQSKNTFDG------YICECGGLIRPDIVFFSESVRYLEESYTLIDNSSTLIVVGSSL 178 Query: 181 HVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEK 231 VYPAA AK +N + + + Y + + + Sbjct: 179 QVYPAAYLPIYAKKQNKTLAIINKGKTPLDDYADIIIYDDIVETFEKIAKH 229 >UniRef50_B2A496 Silent information regulator protein Sir2 n=1 Tax=Natranaerobius thermophilus JW/NM-WN-LF RepID=B2A496_NATTJ Length = 252 Score = 255 bits (651), Expect = 1e-66, Method: Composition-based stats. Identities = 74/237 (31%), Positives = 102/237 (43%), Gaps = 14/237 (5%) Query: 8 VLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQPEI 67 VLTGAGIS ESGI FR DGLW + +T E PE + R +QL E Sbjct: 22 VLTGAGISTESGIPDFRGKDGLWTKIDPMQYSTREVLMSVPEKFYEYGFERFKQLANKE- 80 Query: 68 QPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVLDW 127 PN H LA L+ G +VTQNID LH++AG+ V +HG K C Q + Sbjct: 81 -PNQGHKILADLEKH-GVISGIVTQNIDGLHQKAGSKQVFEVHGNTRKCYCLGCNQEYPF 138 Query: 128 TG-----DVTPEDKCHCCQFPAPLRPHVVWFGE-MPLGMDEIYMALSM-ADIFIAIGTSG 180 + +D C + LRP ++ FG+ MP ++ L D + IGTS Sbjct: 139 QELSDQLEKEQKDVPKCKECGGMLRPDIILFGDQMPDLFFKVTTVLKQRCDFLLVIGTSL 198 Query: 181 HVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKGLK 237 VYP A G +NLE + + G + + + + + L Sbjct: 199 QVYPVAALAEL----GIPMGIINLEETPFDRQAEVVIQGKCGETLSQLWDHMKDELS 251 >UniRef50_C8X5T0 Silent information regulator protein Sir2 n=3 Tax=Desulfovibrionales RepID=C8X5T0_DESRD Length = 254 Score = 254 bits (649), Expect = 2e-66, Method: Composition-based stats. Identities = 73/237 (30%), Positives = 106/237 (44%), Gaps = 8/237 (3%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 + + TGAGIS SGI FR+ GLW + E V + ++P V F Sbjct: 18 DSRCTVAFTGAGISVPSGIPDFRSPGGLWSRYDPEQVCSEWALRKNPVGVWEFLRDALEL 77 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 PN AH+ALA+L+ G ++TQNIDNLH+ AG+ VI HG + C Sbjct: 78 F--DTATPNQAHIALAELEQQ-GLLSAVITQNIDNLHQEAGSQEVIEYHGNCRRYYCHGC 134 Query: 122 GQVLD---WTGDVTPEDKCHCCQFPAPLRPHVVWFGEM--PLGMDEIYMALSMADIFIAI 176 V + C A +RP VV+FGE + AD+ I + Sbjct: 135 AASYPSDQIAAQVRRKIPVLCASCEAVIRPDVVFFGEAIPQEALFRSAALAREADVMIVV 194 Query: 177 GTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLL 233 GTSG V PA E G +E N+ P+ + + ++ G A +++P ++LL Sbjct: 195 GTSGTVAPANIIPQEVAARGGTVIECNIGPTAYADVTSIRFDGAAEEILPLLAQQLL 251 >UniRef50_Q8NSM4 NAD-dependent deacetylase n=15 Tax=Corynebacterium RepID=NPD_CORGL Length = 258 Score = 252 bits (645), Expect = 6e-66, Method: Composition-based stats. Identities = 77/240 (32%), Positives = 121/240 (50%), Gaps = 11/240 (4%) Query: 2 EKPRVLVLTGAGISAESGIRTFRA-ADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 E + V TGAG+SA+SG+ T+R GLW + +A+ + + +DPE + A+Y R Sbjct: 19 EARNIEVFTGAGMSADSGLETYRDDKTGLWSNVDPQAMASIDAWRKDPEPMWAWYRWRAG 78 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVT-QNIDNLHERAGNTNVIHMHGELLKVRCS 119 +PNA H A++ + + + +T QNIDNLHERAG+++V H+HG L + RCS Sbjct: 79 V--AARAEPNAGHQAISYWEGSDTVEHVHITTQNIDNLHERAGSSDVTHLHGSLFEYRCS 136 Query: 120 QSGQVLDWTGDVTPED-----KCHCCQFPAPLRPHVVWFGEM--PLGMDEIYMALSMADI 172 + + E C + +RP VVWFGE D ++ AD+ Sbjct: 137 DCATPWEDDKNYPQEPIARLAPPQCEKCGGLIRPGVVWFGENLPVEEWDIAEQRIAEADL 196 Query: 173 FIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 I +GTSG V+PAA A+ G VE++ +++ + A+Q +P + L Sbjct: 197 MIIVGTSGIVHPAAALPQLAQQRGVPIVEISPTRTELSRIADFTWMSTAAQALPALMRGL 256 >UniRef50_Q88BY5 NAD-dependent deacetylase n=11 Tax=Pseudomonas RepID=NPD_PSEPK Length = 262 Score = 252 bits (644), Expect = 9e-66, Method: Composition-based stats. Identities = 86/239 (35%), Positives = 125/239 (52%), Gaps = 13/239 (5%) Query: 3 KPRVLVLTGAGISAESGIRTFRAA-DGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 V+ TGAGISA+SGI TFR GLW +H + + T + F +P LV ++Y RR Q Sbjct: 14 SKTVVFFTGAGISADSGIPTFRDKLTGLWAKHDPQRLETADAFRANPTLVWSWYLWRRHQ 73 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 + + +PN+AHL++ +L DA G +VTQNID+LHERAG++ V+H+HG L+ V+C Sbjct: 74 V--SQAKPNSAHLSIPQLADA-GWDVSVVTQNIDDLHERAGSSPVVHLHGSLMDVKCFGC 130 Query: 122 GQVLDWTGDVTPED-------KCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMADI 172 + + + D C + LRP VVWF E + D+ Sbjct: 131 HRPAELSPDQLAVPLEGQLIEPPRCTRCNGRLRPGVVWFRENLPDNAWRSAVRLVRACDL 190 Query: 173 FIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEK 231 +++GTSG V PAAG A GA + +NLE + GPA V+P ++ Sbjct: 191 LVSVGTSGVVMPAAGIPDMALAVGATVIHVNLEDVGMDGADEIMLEGPAGVVLPALLQA 249 >UniRef50_B8F955 Silent information regulator protein Sir2 n=1 Tax=Desulfatibacillum alkenivorans AK-01 RepID=B8F955_DESAA Length = 246 Score = 251 bits (641), Expect = 2e-65, Method: Composition-based stats. Identities = 77/230 (33%), Positives = 118/230 (51%), Gaps = 6/230 (2%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQP 65 V+ LTGAG+S ESGI FR GLWE+ ++A + F +PE V A + + Sbjct: 18 VVALTGAGVSVESGIPPFRGKGGLWEKFDPMEIAHIDSFLANPERVWRILVAEMKGVI-D 76 Query: 66 EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVL 125 + QPN H LA+L++ G+ ++TQN+D LH+ AG+ +VI HG + RC + Sbjct: 77 KAQPNNLHKGLARLEE-TGNLAAIITQNVDGLHQAAGSKDVIEFHGTFAEQRCMDCEAKI 135 Query: 126 DWTGDVTPEDKCHCCQFPAPLRPHVVWFGEM--PLGMDEIYMALSMADIFIAIGTSGHVY 183 T +V+ E C LRP V+FGEM + D+ + +GTS V Sbjct: 136 P-TSEVSLEVIPPRCSCGGMLRPDCVFFGEMIPSEALWRSKELAEQCDVMMVVGTSAIVE 194 Query: 184 PAAGFVHEAKLHGAHTVELNLEPSQV-GNEFAEKYYGPASQVVPEFVEKL 232 PAA AKL GA +E+N+E + + G +G A +++ +E++ Sbjct: 195 PAASMARIAKLGGATVIEMNMERTMLTGRVADYSLFGGAGKLMTGILEEM 244 >UniRef50_Q9WYW0 NAD-dependent deacetylase n=5 Tax=Thermotogaceae RepID=NPD_THEMA Length = 246 Score = 251 bits (641), Expect = 2e-65, Method: Composition-based stats. Identities = 71/235 (30%), Positives = 112/235 (47%), Gaps = 9/235 (3%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 E + LTGAGIS SGI FR +G+++++ ++V + F PE F A+ Sbjct: 12 ESRLTVTLTGAGISTPSGIPDFRGPNGIYKKYS-QNVFDIDFFYSHPEEFYRF--AKEGI 68 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 + +PN AH+ LAKL++ G ++TQNID LH+RAG+ VI +HG + + C + Sbjct: 69 FPMLQAKPNLAHVLLAKLEEK-GLIEAVITQNIDRLHQRAGSKKVIELHGNVEEYYCVRC 127 Query: 122 GQVL---DWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPL--GMDEIYMALSMADIFIAI 176 + D + D C + +RP++V+FGE + E S A + I + Sbjct: 128 EKKYTVEDVIKKLESSDVPLCDDCNSLIRPNIVFFGENLPQDALREAIGLSSRASLMIVL 187 Query: 177 GTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEK 231 G+S VYPAA G V +NL + + KY + +E+ Sbjct: 188 GSSLVVYPAAELPLITVRSGGKLVIVNLGETPFDDIATLKYNMDVVEFARRVMEE 242 >UniRef50_D1A1X3 Silent information regulator protein Sir2 n=13 Tax=Actinomycetales RepID=D1A1X3_THECD Length = 259 Score = 251 bits (641), Expect = 2e-65, Method: Composition-based stats. Identities = 80/242 (33%), Positives = 118/242 (48%), Gaps = 11/242 (4%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEE-HRVEDVATPEGFDRDPELVQAFYNARRR 60 E + VLTGAGIS +SGI FR G+W + +++ + + DP++ + + ARR Sbjct: 11 EARSITVLTGAGISTDSGIPDFRGPQGVWTKDPSAAALSSLDAYLADPQVRRRVWQARRD 70 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGN--TNVIHMHGELLKVRC 118 +PNAAHLAL KL+ A G +VTQNID LH+ AG+ VI +HG + +V C Sbjct: 71 HPAW-HAEPNAAHLALVKLERA-GRLRAIVTQNIDGLHQAAGSSPKTVIEIHGTMREVEC 128 Query: 119 SQSGQVLDWTGDVTP----EDKCHCCQFPAPLRPHVVWFGE--MPLGMDEIYMALSMADI 172 + G + E C + + + FG+ P + A D+ Sbjct: 129 LECGLRTPTQQVLKRLEEGEADPPCLECGGIQKAATISFGQALRPQVLQAAVRAARSCDL 188 Query: 173 FIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 F+A+GTS V+PAAG EA HGA V +N +P+ P + +P VE Sbjct: 189 FMAVGTSLTVHPAAGLCLEAVEHGARLVIVNAQPTPYDGIADAVLREPIGEALPGLVELA 248 Query: 233 LK 234 L+ Sbjct: 249 LR 250 >UniRef50_A6DC77 Silent information regulator protein Sir2 n=1 Tax=Caminibacter mediatlanticus TB-2 RepID=A6DC77_9PROT Length = 243 Score = 251 bits (641), Expect = 2e-65, Method: Composition-based stats. Identities = 71/235 (30%), Positives = 114/235 (48%), Gaps = 7/235 (2%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 + ++ TGAGIS ESGI TFR GLW ++ + + F ++P+ + Sbjct: 13 DSKNLVAFTGAGISVESGIPTFRGPTGLWSKYDP-KILDIDFFIQNPKESWKYIKEIFYD 71 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 +I+PN AH LA L+ G ++TQNIDNLH++AG+ NVI HG K+ C Sbjct: 72 -YMQDIKPNEAHYFLADLEKK-GILKAVITQNIDNLHQKAGSKNVIEFHGTANKLECLNC 129 Query: 122 GQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMAL---SMADIFIAIGT 178 + C + L+P V+F E P+ + ++ ADI + IGT Sbjct: 130 KSKFNSFEVPLENIPPLCPKCNGVLKPDFVFFKE-PIPKEAFEKSIYYSQNADIMLVIGT 188 Query: 179 SGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLL 233 +G + PA+ AK +GA +E+N+EPS N + + + + + ++ L Sbjct: 189 TGEIMPASELPLLAKQNGAAIIEINIEPSNYTNSITDIFLKDKATIAAKKLKSLF 243 >UniRef50_B9L9A0 NAD-dependent deacetylase n=4 Tax=Bacteria RepID=B9L9A0_NAUPA Length = 248 Score = 250 bits (639), Expect = 3e-65, Method: Composition-based stats. Identities = 73/240 (30%), Positives = 116/240 (48%), Gaps = 15/240 (6%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQA-----FYNA 57 + + TGAGIS ESGI TFR +GLW ++ + + F +P+ FY+ Sbjct: 15 SKKAVAFTGAGISVESGIPTFRGPNGLWSKYDP-KILDIDYFTLNPKDAWEKIKEIFYD- 72 Query: 58 RRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVR 117 I+PN AH LA L+ ++TQNIDNLH+ AG+ NVI HG + Sbjct: 73 -----YMQNIKPNDAHYFLADLEKEK-MLEAVITQNIDNLHQEAGSKNVIEFHGTAKNLV 126 Query: 118 CSQSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGE-MP-LGMDEIYMALSMADIFIA 175 C + D + C + L+P+ V+F E +P +++ D+ + Sbjct: 127 CMNCFKKYDKDVVDLNDLPPACPKCWGLLKPNFVFFKEPIPKKALEKSLELAQDCDLMLV 186 Query: 176 IGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKG 235 IGT+G + PA+ AK +GA +E+N+EPS N + + + V + +++ LKG Sbjct: 187 IGTTGEIQPASQIPILAKENGAKIIEINIEPSNYTNTITDIFLQDKATVASKKLKEELKG 246 >UniRef50_B5YJW3 NAD-dependent deacetylase n=1 Tax=Thermodesulfovibrio yellowstonii DSM 11347 RepID=NPD_THEYD Length = 256 Score = 249 bits (637), Expect = 5e-65, Method: Composition-based stats. Identities = 75/237 (31%), Positives = 114/237 (48%), Gaps = 13/237 (5%) Query: 7 LVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQP- 65 + TGAGIS ESGI FR+ +GLW+ R + T + F D + F+ +R +Q+ Sbjct: 23 VAFTGAGISTESGIPDFRSPNGLWQRFR---IVTYQEFIIDRKARNEFWKMKRELIQEII 79 Query: 66 EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVL 125 +PN AH ALA+L+ G ++TQNID LH+ AGN +VI +HG C +V Sbjct: 80 NAKPNNAHNALAELEKR-GLLKYVITQNIDGLHQMAGNKSVIELHGNQRGYICLDCEKVY 138 Query: 126 DWTGD----VTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMA---LSMADIFIAIGT 178 E C ++P +V+FGE P+ E+ MA + DI IGT Sbjct: 139 PLEEVLKMLKEQELDLRCEVCGGIIKPTIVFFGE-PMPEKELLMAQQIANKCDIMFVIGT 197 Query: 179 SGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKG 235 S V PAA A +GA + +N ++ +Y A +V+ + ++ + Sbjct: 198 SLQVEPAASIPRIAYQNGAKLIFINKVQTEWDWIAEIIFYDSAGKVLKDILDVIKSE 254 >UniRef50_O07595 NAD-dependent deacetylase n=5 Tax=Bacillus RepID=NPD_BACSU Length = 247 Score = 249 bits (636), Expect = 7e-65, Method: Composition-based stats. Identities = 73/232 (31%), Positives = 107/232 (46%), Gaps = 13/232 (5%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEE-HRVEDVATPEGFDRDPELVQAFYNARRR 60 E R++VLTGAG+S ESGI FR+A G+W E + + + F P L + + Sbjct: 10 EAQRIVVLTGAGMSTESGIPDFRSAGGIWTEDASRMEAMSLDYFLSYPRLFWPKFKELFQ 69 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 +PN HL LA+L+ G + + TQNID LH++AG+ +V +HG + C Sbjct: 70 MKMSGSFEPNEGHLLLAELE-KQGKQVDIFTQNIDGLHKKAGSRHVYELHGSIQTAACPA 128 Query: 121 SGQVLDWTGDVTPEDKCHCCQ--------FPAPLRPHVVWFGEMPLGMDEIYMALSMADI 172 G D E + C L+ VV FG+ + D +Y L AD+ Sbjct: 129 CGARYDLP--HLLEREVPECTAAGNNGDICGTVLKTDVVLFGDAVMHFDTLYEKLDQADL 186 Query: 173 FIAIGTSGHVYPAAGFVHEAKL-HGAHTVELNLEPSQVGNEFAEKYYGPASQ 223 + IGTS V PA +A L G V +NLEP+ + F + + Sbjct: 187 LLVIGTSLEVAPARFVPEDASLIPGMKKVIINLEPTYCDSLFDMVIHQKIGE 238 >UniRef50_B1I1N5 Silent information regulator protein Sir2 n=1 Tax=Candidatus Desulforudis audaxviator MP104C RepID=B1I1N5_DESAP Length = 249 Score = 248 bits (635), Expect = 9e-65, Method: Composition-based stats. Identities = 74/236 (31%), Positives = 107/236 (45%), Gaps = 13/236 (5%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 E R L LTGAGIS SGI FR+ G WE+ +V++ + F RDP + + Sbjct: 18 ESARTLALTGAGISTASGIPDFRSRGVGRWEKVDPMEVSSVQAFQRDPAAFWRY--NLKW 75 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 L+ + +PN AH LA L+ ++TQN+D LH RAG+ +HG L RC Sbjct: 76 WLEFADAEPNPAHHVLATLERRK-LLQGVITQNVDGLHVRAGSQT-WEVHGHLRTCRCLG 133 Query: 121 SGQVLDWT---GDVTPEDKCHCCQFPAPLRPHVVWFGEMP-LGMDEIYMALSMADIFIAI 176 G ++T C A LRP VV FG+M ++ L + I + Sbjct: 134 CGGRYEFTFLVEQFQAGKNPPRCPCGALLRPDVVLFGDMLGDAFEQAVQVLHGCPLLIVV 193 Query: 177 GTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 G+S VYP A A+ V +N +P+ ++ A G QV + +L Sbjct: 194 GSSLQVYPVAALPRLAR----RLVIINRDPTPWDDQAALILRGDIVQVFEKLAAEL 245 >UniRef50_C6BY08 Silent information regulator protein Sir2 n=1 Tax=Desulfovibrio salexigens DSM 2638 RepID=C6BY08_DESAD Length = 248 Score = 248 bits (635), Expect = 1e-64, Method: Composition-based stats. Identities = 78/236 (33%), Positives = 108/236 (45%), Gaps = 7/236 (2%) Query: 1 MEKPRV-LVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARR 59 ++K R + LTGAG+S SGI FR+ GLW +H E VA+ DP V F Sbjct: 15 IKKARCAIALTGAGMSVASGIPDFRSPGGLWSKHDPEKVASIRALQSDPVTVWKFLLEAD 74 Query: 60 RQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCS 119 L+ E PNA H LA+L+ G ++TQNID LH+RAG+ NVI HG + C Sbjct: 75 SMLKSAE--PNAGHTGLAQLE-KDGFLQGVITQNIDGLHQRAGSVNVIEFHGNCSEFYCM 131 Query: 120 QSGQVLDWTG-DVTPEDKCHCCQFPAPLRPHVVWFGEM--PLGMDEIYMALSMADIFIAI 176 + + E C Q +RP +V+FGE + +D+ I Sbjct: 132 ECFAPFPAERIESGSELPVRCPQCSGVIRPDLVFFGEQIPSEAYKAAFELADQSDLVIVA 191 Query: 177 GTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 GTSG V PA+ + G +E+N PS + G V+P V+ L Sbjct: 192 GTSGGVVPASLIPPRIQEAGGLIIEINKAPSAYTSFSDVFIQGAVEDVLPAIVQNL 247 >UniRef50_C2AS85 NAD-dependent protein deacetylase, SIR2 family n=1 Tax=Tsukamurella paurometabola DSM 20162 RepID=C2AS85_TSUPA Length = 273 Score = 247 bits (631), Expect = 2e-64, Method: Composition-based stats. Identities = 95/249 (38%), Positives = 129/249 (51%), Gaps = 20/249 (8%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAA-DGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 + ++VLTGAG+SAESGI TFR A GLW + E++A+ + + RD LV +Y R Sbjct: 26 DAESIVVLTGAGMSAESGIATFREAQTGLWARYDPEEIASVDAWTRDSALVWGWYQWRGY 85 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 +Q E PN H+ALA+L +VTQNID+LHERAG+ H+HG L RC Sbjct: 86 IARQAE--PNNGHIALAELGTR--RSVSIVTQNIDDLHERAGSEVTAHLHGSLFAPRCEY 141 Query: 121 SGQVL--------DWTGDVTPEDK---CHCCQFPAPLRPHVVWFGEMPLGMD---EIYMA 166 G G+ TPE + C Q + +RP +VWFGE PL M+ A Sbjct: 142 CGTPYLGSDAEIRATDGEPTPEMRVTPPTCMQCLSQVRPGIVWFGE-PLPMEAWGRAEAA 200 Query: 167 LSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVP 226 + AD+ + IGTSG VYPAA A G VE+N EP+ + + A+ +P Sbjct: 201 VIAADLVLVIGTSGLVYPAARLPEMALEAGIPVVEINPEPTPLSARATVAWNTTAATGLP 260 Query: 227 EFVEKLLKG 235 V + G Sbjct: 261 ALVAAVTSG 269 >UniRef50_Q9I4L0 NAD-dependent deacetylase 1 n=28 Tax=Bacteria RepID=NPD1_PSEAE Length = 250 Score = 247 bits (631), Expect = 3e-64, Method: Composition-based stats. Identities = 90/243 (37%), Positives = 124/243 (51%), Gaps = 13/243 (5%) Query: 3 KPRVLVLTGAGISAESGIRTFRAA-DGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 R+++ TGAG+SAESGI TFR A GLW + +ATP F DP LV +Y RR Sbjct: 11 ARRLVIFTGAGVSAESGIPTFRDALGGLWARYDPAALATPAAFADDPALVWGWYEWRR-- 68 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 L+ +QPN AH A+A L + + LVTQN+D+LHERAG+ +V+H+HG L RC+ Sbjct: 69 LKVLGVQPNPAHRAIAALSGRIAN-TRLVTQNVDDLHERAGSRDVLHLHGSLHAPRCATC 127 Query: 122 GQVLDWTGDVTPED-------KCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALS--MADI 172 + E C +RP VVWFGE + D+ Sbjct: 128 AAAYRDALPDSVEPEEGRRIEPPRCPACGGQVRPGVVWFGEALPEAALREAFAAACECDL 187 Query: 173 FIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 +++GTSG V PAA A HGA V +N +P + + GPA +V+PE + + Sbjct: 188 LLSVGTSGVVQPAARIPGLALEHGASVVHVNPQPVRTRHPREHCLVGPAGEVLPELLRRA 247 Query: 233 LKG 235 G Sbjct: 248 FPG 250 >UniRef50_A7HL19 Silent information regulator protein Sir2 n=1 Tax=Fervidobacterium nodosum Rt17-B1 RepID=A7HL19_FERNB Length = 244 Score = 247 bits (631), Expect = 3e-64, Method: Composition-based stats. Identities = 66/221 (29%), Positives = 110/221 (49%), Gaps = 9/221 (4%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 VLTGAG+S SGI FR+ +G++ + +++ + F ++P+ F A++ + Sbjct: 14 SKFTTVLTGAGVSVPSGIPDFRSKNGVYSKWG-QEIFDIDLFHQNPDRFYEF--AKQELI 70 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG 122 + +++PN H LA L+ L ++TQNIDNLH++AG+ V +HG + C + G Sbjct: 71 KMLDVEPNEIHYLLAYLE-KLNIVKGVITQNIDNLHKKAGSQKVAEIHGNVRTWSCLKCG 129 Query: 123 QVLDWTGDVTPE---DKCHCCQFPAPLRPHVVWFGEMPL--GMDEIYMALSMADIFIAIG 177 + D E D+ C+ +P +V+FGEM + +D+FIA+G Sbjct: 130 KRYDLFNSQHKEFLIDRNFRCECGGVTKPDIVFFGEMLPLNEYSKAENWAKESDVFIAMG 189 Query: 178 TSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYY 218 TS VYPAA AK GA +N + + + + Sbjct: 190 TSLVVYPAAQLPIYAKHSGAKLCIINKNETVLDDYADLVIH 230 >UniRef50_C6XKE4 Silent information regulator protein Sir2 n=1 Tax=Hirschia baltica ATCC 49814 RepID=C6XKE4_HIRBI Length = 249 Score = 246 bits (630), Expect = 4e-64, Method: Composition-based stats. Identities = 102/238 (42%), Positives = 143/238 (60%), Gaps = 5/238 (2%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 ++ V++LTGAG+S ESGI +R D +W +E+ P+ F ++PELV FYN RR Sbjct: 4 VQFKHVVLLTGAGVSVESGIPVYRNEDEIWTRKEMENFFRPDTFRKNPELVHDFYNKRRM 63 Query: 61 QLQQPEIQPNAAHLALAKLQDAL---GDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVR 117 L +IQPN H +A LQD L + ++T+N+D+LHE+AG T+VIH+ G+L Sbjct: 64 DL--KKIQPNKTHCHIAYLQDQLLGSRTKLTIITKNVDDLHEKAGTTDVIHILGDLNSAF 121 Query: 118 CSQSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIG 177 C+ + GD+ + C C+ +RP +VW GE P MD+I AL D+F++IG Sbjct: 122 CTICNIRIKCMGDLITQTICSNCKNKKTMRPDIVWAGEKPYHMDKIQAALDECDLFVSIG 181 Query: 178 TSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKG 235 TSG VYP A FV+ AK GA TVELN +PS F YGPAS +VP +V+ + G Sbjct: 182 TSGSVYPTADFVNLAKKTGAVTVELNQKPSANATSFDHTNYGPASTIVPFWVDTFIHG 239 >UniRef50_Q97MB4 NAD-dependent deacetylase n=71 Tax=cellular organisms RepID=NPD_CLOAB Length = 245 Score = 246 bits (629), Expect = 5e-64, Method: Composition-based stats. Identities = 70/232 (30%), Positives = 108/232 (46%), Gaps = 14/232 (6%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWE-----EHRVEDVATPEGFDRDPELVQAFYN 56 E ++ GAG+S ES I FR+ +GL++ + E + + F E FY Sbjct: 16 ESSSIVFFGGAGVSTESNIPDFRSENGLYKTKNNFSYPPEVMLSHTFFKNHTEDFFEFY- 74 Query: 57 ARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKV 116 R ++ + +PNAAH +LAK+++ G +VTQNID LH+ AG+ NV +HG + + Sbjct: 75 --REKMIFKDAKPNAAHYSLAKIEEQ-GKLKAIVTQNIDGLHQLAGSKNVYELHGSIHRN 131 Query: 117 RCSQSGQVLDWTGDVTPEDKCHCC-QFPAPLRPHVVWFGEMPLG--MDEIYMALSMADIF 173 C G+ D + E C + ++P VV + E + A+S AD Sbjct: 132 YCMDCGKSFDLEYVIKSETTIPKCDKCGGIVKPDVVLYEEGLDDSIIQNSVKAISEADTL 191 Query: 174 IAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVV 225 I GTS VYPAAG + K G + +N + NE +V+ Sbjct: 192 IVGGTSLVVYPAAGLIRYFK--GNKLILINKSATAYDNEADLVISDSIGKVL 241 >UniRef50_C6P8W9 Silent information regulator protein Sir2 n=2 Tax=Clostridia RepID=C6P8W9_CLOTS Length = 251 Score = 246 bits (628), Expect = 7e-64, Method: Composition-based stats. Identities = 71/239 (29%), Positives = 107/239 (44%), Gaps = 15/239 (6%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEGFDRDPELVQAFYNA-RR 59 + + +VLTGAGIS ESGI FR+ GLWE+ + + DP FYN + Sbjct: 17 KSKKTIVLTGAGISTESGIPDFRSPGTGLWEKMDPMEALSTRVLYNDP---IKFYNNGFK 73 Query: 60 RQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCS 119 L + +PN AH LA+L+ G ++TQNIDNLH++AG+ V +HG+ C Sbjct: 74 ILLSMKDAKPNKAHYILAQLEQE-GLISGVITQNIDNLHQKAGSHKVFEVHGQTRTGSCI 132 Query: 120 QSGQVLDW----TGDVTPEDKCHCCQFPAPLRPHVVWFGE-MPLGMDEIYMALSMADIFI 174 G+V+ + E C + LRP VV FG+ MP + + +D+ + Sbjct: 133 NCGEVVSIDLLNSKVEKNEIPPKCDKCNGILRPDVVMFGDPMPEDFERAWREAESSDLMV 192 Query: 175 AIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLL 233 IG+S V P K H + +N + AS+ + + L Sbjct: 193 VIGSSLTVSPVNFLPGLVK----HLIIINKSETPEDRRADVVIRESASEALSTILAYLK 247 >UniRef50_B6KET2 NAD-dependent deacetylase, putative n=3 Tax=Toxoplasma gondii RepID=B6KET2_TOXGO Length = 360 Score = 245 bits (627), Expect = 8e-64, Method: Composition-based stats. Identities = 88/242 (36%), Positives = 129/242 (53%), Gaps = 14/242 (5%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAA-DGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 + V+ LTGAG+SAESGI TFR DGLW+++ AT GF R P + Sbjct: 123 KAKYVVALTGAGVSAESGIPTFRDPSDGLWKKYDPTVYATIWGFWRYPHKIWE---LLLD 179 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 L+ + PNAAH+AL LQ LG +VTQN+DNLH+ +G+TNVI HG LL C Q Sbjct: 180 FLRTNDPMPNAAHVALTDLQR-LGYLKFIVTQNVDNLHQDSGSTNVIEYHGSLLSATCRQ 238 Query: 121 SGQVLDWTGDVTPE-----DKCHCCQFPAPLRPHVVWFGE-MPLG-MDEIYMALSMADIF 173 G+ + + + + D C +P V+ FGE +P + + + D+ Sbjct: 239 CGKKMRLSKSMLQDENFAKDLPPKCACGGIFKPDVILFGEGIPANAVRDANREVDKCDLL 298 Query: 174 IAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKY-YGPASQVVPEFVEKL 232 + +GTS V PA+ + A GA VE+NLE + + N ++K+ G ASQ + + V+ L Sbjct: 299 LVVGTSASVSPASDLPYRAMRGGAKVVEVNLETTGLTNRISDKFVQGRASQ-LAQTVKAL 357 Query: 233 LK 234 + Sbjct: 358 QR 359 >UniRef50_C4GC77 Putative uncharacterized protein n=3 Tax=Clostridiales RepID=C4GC77_9FIRM Length = 281 Score = 244 bits (623), Expect = 2e-63, Method: Composition-based stats. Identities = 72/254 (28%), Positives = 112/254 (44%), Gaps = 31/254 (12%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWE---EHRVEDVATPEGFDRDPELVQAFY---- 55 +++ GAG+S ESG++ FR+ DGL+ ++ E + + F R PE FY Sbjct: 20 ASKIVFFGGAGVSTESGLKDFRSQDGLYHEHYKYPPERILSHSFFMRQPEDFYRFYFDKL 79 Query: 56 ---------------NARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHER 100 R + I+PNAAH LA+L+ A G ++TQNID LH+R Sbjct: 80 LVDGLAVPKSSGRIGTPARGERSSGVIEPNAAHKKLAELETA-GKLSAVITQNIDGLHQR 138 Query: 101 AGNTNVIHMHGELLKVRCSQSGQVLD----WTGDVTPEDKCHCCQFPAPLRPHVVWFGEM 156 AG+ V +HG + + C G D + HC ++P VV + E Sbjct: 139 AGSRKVFELHGSIHRNHCMSCGHFFDGEYLLAHRDAEKPVPHCPVCGGIIKPDVVLYEEG 198 Query: 157 PLG--MDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFA 214 ++ A+ AD+ I GTS VYPAAGF+ G H V +N + + Sbjct: 199 LDQSVINGALEAIGEADLLIIGGTSLTVYPAAGFIRY--YRGNHLVLINRDATGQDELAD 256 Query: 215 EKYYGPASQVVPEF 228 +G +++ + Sbjct: 257 LVIHGSIGEILGKI 270 >UniRef50_Q81BT4 NAD-dependent deacetylase n=75 Tax=Bacillus RepID=NPD_BACCR Length = 245 Score = 244 bits (623), Expect = 2e-63, Method: Composition-based stats. Identities = 68/228 (29%), Positives = 104/228 (45%), Gaps = 3/228 (1%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 + ++ VLTGAG S ESGI FR+A+GL+ + VE + ++R P+ Y + Sbjct: 16 KAKKITVLTGAGASTESGIPDFRSANGLYADANVEMYLSRGYYNRSPKEFWKHYKEIFQI 75 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 + +PN H LA+L++ G ++TQNID LH+ G+ +VI +HG L C + Sbjct: 76 NTFHQYKPNRGHRFLAELEEQ-GKDITILTQNIDGLHQLGGSKHVIDLHGTLQTAHCPKC 134 Query: 122 GQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGH 181 D + + C + L P VV +G+ L D+ I +GTS Sbjct: 135 KSGYDL-QYMIDHEVPRCEKCNFILNPDVVLYGDTLPQYQNAIKRLYETDVLIVMGTSLK 193 Query: 182 VYPAAGFVHEAKLH-GAHTVELNLEPSQVGNEFAEKYYGPASQVVPEF 228 V P A F AK GA T+ +N E + F + + V Sbjct: 194 VQPVASFPQIAKREVGATTILVNEELTGQEYNFDFVFQNKIGEFVEGL 241 >UniRef50_D2RNB5 Silent information regulator protein Sir2 n=1 Tax=Acidaminococcus fermentans DSM 20731 RepID=D2RNB5_ACIFE Length = 257 Score = 243 bits (622), Expect = 3e-63, Method: Composition-based stats. Identities = 75/245 (30%), Positives = 118/245 (48%), Gaps = 24/245 (9%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLW-------EEHRVEDVATPEGFDRDPELVQAF 54 E ++ GAG+S SGI FR+ DGL+ +++R E + + +P++ F Sbjct: 19 EADHIVFFGGAGVSTASGIPDFRSKDGLYNQHDVRFDQYRPEYLLSHSCLVNEPKVYFEF 78 Query: 55 YNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELL 114 + R+++ +IQPN AH LA L+ G +VTQNID LH++AG+ V +HG L Sbjct: 79 H---RQKMDTRKIQPNNAHKYLAALE-KTGKLDGIVTQNIDGLHQKAGSRKVYEIHGSAL 134 Query: 115 KVRCSQSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMADI 172 + C G+ ++ C +RP + + EM ++ A+S AD+ Sbjct: 135 RNYCMSCGKRYPSDYIFESKEPIPHCTCGGVIRPDITLYEEMLPDEAVENAVRAISRADL 194 Query: 173 FIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQ-VVPEFVEK 231 I GTS VYPAA F++ HG V LN +P + A V+ E ++K Sbjct: 195 MIIAGTSLTVYPAASFINYF--HGKRLVILNRDP--------LSVHMKAETLVITENMDK 244 Query: 232 LLKGL 236 + K L Sbjct: 245 VFKAL 249 >UniRef50_A0LG97 Silent information regulator protein Sir2 n=1 Tax=Syntrophobacter fumaroxidans MPOB RepID=A0LG97_SYNFM Length = 248 Score = 243 bits (621), Expect = 4e-63, Method: Composition-based stats. Identities = 79/235 (33%), Positives = 109/235 (46%), Gaps = 7/235 (2%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 + +VLTGAGIS ESGI FR+ DGLW ++ + F +P V Sbjct: 12 LRSRYTVVLTGAGISVESGIPDFRSKDGLWSKYDPAEYGYIGSFRANPAKVWTMLTEMDA 71 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 L+ + +PN AHLALA L+ G LVTQNID+LH+RAG+ NVI HG +RC + Sbjct: 72 VLR--QARPNFAHLALADLEKR-GIVKELVTQNIDSLHQRAGSKNVIEFHGHNRSLRCDR 128 Query: 121 SGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEM--PLGMDEIYMALSMADIFIAIGT 178 +V V+ C LRP +V+FGE P A D + +GT Sbjct: 129 CQKVYARES-VSLATLPPACACGNALRPEIVFFGEDIPPQAYRSALNAAQKCDFMMIVGT 187 Query: 179 SGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNE-FAEKYYGPASQVVPEFVEKL 232 S V PA+ AK GA +E+N S++ A++ + L Sbjct: 188 SASVAPASQLPLVAKSRGAFILEINPMDSELTRRTTDLHICERATRAFEAIMAAL 242 >UniRef50_D1UAS5 Silent information regulator protein Sir2 n=1 Tax=Desulfovibrio aespoeensis Aspo-2 RepID=D1UAS5_9DELT Length = 249 Score = 243 bits (620), Expect = 5e-63, Method: Composition-based stats. Identities = 76/235 (32%), Positives = 111/235 (47%), Gaps = 16/235 (6%) Query: 7 LVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQA-----FYNARRRQ 61 + TGAGIS ESGI FR G+W +H + F R P+ V F++ Sbjct: 20 IAFTGAGISVESGIPPFRGPGGVWSKHDPDKFE-KTYFQRHPQEVWPLLKEIFFDTL--- 75 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 +PN AHLALAKL++A G ++TQNID LH+ AG+ V HG ++ C Sbjct: 76 ---GRARPNPAHLALAKLEEA-GRLAAIITQNIDGLHQAAGSKTVYEYHGSTRRMECLDC 131 Query: 122 GQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGE-MPLGMDEIYMAL-SMADIFIAIGTS 179 G D C L+P V+F E +P + + L +D+ + +GT Sbjct: 132 GAFFDSASIPLDRLPPPCPACGGLLKPDFVFFSEPIPFEVHQAATNLARQSDVCLIVGTG 191 Query: 180 GHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKY-YGPASQVVPEFVEKLL 233 G V PA HE + G VE+NL ++ F++ + G A +VPE V ++ Sbjct: 192 GEVMPAGRIPHEVRNAGGKVVEINLYETRYSYGFSDVFLQGRAGVLVPELVGMVM 246 >UniRef50_C7RQR7 Silent information regulator protein Sir2 n=1 Tax=Candidatus Accumulibacter phosphatis clade IIA str. UW-1 RepID=C7RQR7_9PROT Length = 253 Score = 243 bits (620), Expect = 6e-63, Method: Composition-based stats. Identities = 83/235 (35%), Positives = 119/235 (50%), Gaps = 9/235 (3%) Query: 3 KPRVLVLTGAGISAESGIRTFR-AADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 V+V +GAG+SA+SGI TFR A GLW ++VA+ EGF R P +V + + Sbjct: 16 AREVVVFSGAGLSADSGIPTFRDGATGLWNNVDPDEVASIEGFLRKPRVVWDWLLQLKNL 75 Query: 62 LQQPEIQPNAAHLALAKLQDA-LGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 + + PNA H A+A+L+D G R ++TQNID H +AGN V+ +HG + +VRC + Sbjct: 76 V--DDRHPNAGHEAIARLEDLCKGKRLTIITQNIDGYHTQAGNAQVLEVHGTIHRVRCHR 133 Query: 121 -SGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALS--MADIFIAIG 177 G W + + + C P+RP +V FGEM + AD+F +G Sbjct: 134 RCGFAAVW--EQSAVEPFSCPNCGGPVRPDLVLFGEMLDEEVFAAAGIRSLNADLFFCVG 191 Query: 178 TSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 TS V PAA AK GA VE+N P+ + + ASQ +L Sbjct: 192 TSFTVQPAARLPVWAKGAGATVVEVNPHPTPLSDAADYSIRAGASQFFGALCARL 246 >UniRef50_Q899G3 NAD-dependent deacetylase n=52 Tax=Bacteria RepID=NPD_CLOTE Length = 247 Score = 242 bits (619), Expect = 7e-63, Method: Composition-based stats. Identities = 71/239 (29%), Positives = 111/239 (46%), Gaps = 16/239 (6%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWE-----EHRVEDVATPEGFDRDPELVQAFYNA 57 ++ GAG+S ES I FR+ +GL++ + E + + F E FY Sbjct: 14 SSNIVFFGGAGVSTESNIPDFRSEEGLYKTKSNFSYSPEVMLSHSFFKEHTEDFFDFY-- 71 Query: 58 RRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVR 117 + ++ +PN AH ALAKL+ +G ++TQNID LH+ AG+ NVI +HG + + Sbjct: 72 -KEKMIYKYAKPNLAHHALAKLE-KVGKLKAIITQNIDGLHQLAGSKNVIELHGGVGRNY 129 Query: 118 CSQSGQVLDWTGDVTPEDKCHCCQ-FPAPLRPHVVWFGEMPLGMDEIYMA---LSMADIF 173 C + D + ++ C ++P VV + E PL MD I A + +D+ Sbjct: 130 CMDCNKFFDLNYILNNKEVVPKCDVCGGIVKPDVVLYEE-PLNMDNINNAVRYVENSDVL 188 Query: 174 IAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 I GTS VYPAA +H K G V +N + + ++ VE+L Sbjct: 189 IVGGTSLVVYPAANLIHYYK--GNKLVLINKSSTPYDRKAQIVINDSIGSILGGIVEEL 245 >UniRef50_Q67KQ0 NAD-dependent deacetylase n=1 Tax=Symbiobacterium thermophilum RepID=NPD_SYMTH Length = 251 Score = 242 bits (618), Expect = 9e-63, Method: Composition-based stats. Identities = 68/224 (30%), Positives = 95/224 (42%), Gaps = 9/224 (4%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 + LTGAG S ESG+ FR+ GLW++ + + R P FY R L Sbjct: 15 SRYAVALTGAGASTESGLPDFRSNTGLWKDVDPVSLISMTALRRRPVDFYRFYRMRFSHL 74 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG 122 QPN H LA LQ G L+TQN+D LH+ AG+ +VI +HG L + +C + G Sbjct: 75 W--GAQPNPVHKVLAALQRE-GLLKRLITQNVDGLHQAAGSPDVIELHGSLRECQCLRCG 131 Query: 123 QVLDW----TGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALS--MADIFIAI 176 + T D C + L+P VV F E + AD+F+ + Sbjct: 132 RRFPSRLIDVEVETEADIPRCPECGGVLKPGVVLFEEALPADAIEAAIEAAMKADLFLVV 191 Query: 177 GTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGP 220 G+S V PA A HG NL P+ + + Sbjct: 192 GSSLEVGPANQLPVLAVQHGGRLAIFNLTPTFLDPRATWIFREK 235 >UniRef50_C0GF21 Silent information regulator protein Sir2 n=1 Tax=Dethiobacter alkaliphilus AHT 1 RepID=C0GF21_9FIRM Length = 247 Score = 241 bits (617), Expect = 1e-62, Method: Composition-based stats. Identities = 70/237 (29%), Positives = 105/237 (44%), Gaps = 16/237 (6%) Query: 3 KPRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 +VLTGAGIS ESGI FR+ GLWE+ ED T + F RDP +FY Sbjct: 17 ANYAVVLTGAGISTESGIPDFRSPGTGLWEKEDPEDF-TIDSFQRDP---HSFYRRIHPL 72 Query: 62 LQ-QPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 L+ + +PN H ALA L+ + G L+TQN+D LH++AG+ NV+ +HG C Sbjct: 73 LKVIDKAEPNPGHTALADLETS-GIIKSLITQNVDGLHQKAGSKNVLEVHGSFQTGTCHD 131 Query: 121 SGQV---LDWTGDVTPEDKCHCCQFPAP-LRPHVVWFG-EMPLGMDEIYMALSMADIFIA 175 + D +T C ++P V FG EMP + D + Sbjct: 132 CRKKSGLADLNLLLTAGKDPDCPHCGGNTVKPDVTLFGEEMPPDFQLAHREALKCDCMLV 191 Query: 176 IGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 +G+S V P AK + +N + + + QV+ + + ++ Sbjct: 192 VGSSLQVAPVGFLPRYAKN----LLIINRGSTPYDDHAQVVIREGSGQVLTDIIAEI 244 >UniRef50_C4FX59 Putative uncharacterized protein n=1 Tax=Catonella morbi ATCC 51271 RepID=C4FX59_9FIRM Length = 259 Score = 240 bits (614), Expect = 2e-62, Method: Composition-based stats. Identities = 74/238 (31%), Positives = 114/238 (47%), Gaps = 16/238 (6%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLW-----EEHRVEDVATPEGFDRDPELVQAFYN 56 + ++ GAG+S ESGI FR+A G++ E + + + + P+L FY Sbjct: 24 DSHHLVFFGGAGVSTESGIPDFRSAQGVYSQDLGRNFSAEQLISHSMYQKYPQLFYDFY- 82 Query: 57 ARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKV 116 R+ L P +PNAAH+ LA+L+ A G +++QNID LHE AG+ V+ +HG + + Sbjct: 83 --RKHLIYPHAKPNAAHIFLAQLE-ASGHLDAVISQNIDTLHEAAGSQCVLKLHGTVDRN 139 Query: 117 RCSQSGQVLD---WTGDVTPEDKCHCCQFPAPLRPHVVWFGEMP--LGMDEIYMALSMAD 171 C + G+V D + + C L+P V + E D+ +A+ AD Sbjct: 140 ICQECGRVYDLKSFLDAYDSQGIPRCPHCGGVLKPDVTLYEESLNMEVFDQAILAIQQAD 199 Query: 172 IFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFV 229 I GTS VYPAAG + K G H V +N + + + P QV + V Sbjct: 200 TLIVGGTSLVVYPAAGLLQYFK--GKHLVVINKQAIPQDDWADLVIHAPIGQVFSQLV 255 >UniRef50_Q8CJM9 NAD-dependent deacetylase 2 n=8 Tax=Actinomycetales RepID=NPD2_STRCO Length = 241 Score = 240 bits (614), Expect = 3e-62, Method: Composition-based stats. Identities = 77/239 (32%), Positives = 109/239 (45%), Gaps = 11/239 (4%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEE-HRVEDVATPEGFDRDPELVQAFYNARRRQ 61 KP V +L+GAG+S +SGI +R +GLW E + T E + DPE+ + + RR Sbjct: 4 KPLVAILSGAGVSTDSGIPDYRGPNGLWRRDPEAEKLVTYEYYMGDPEIRRRSWLMRRDS 63 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELLKVRCS 119 +PNAAH A+A L+ G ++TQN+D LH+ AG V+ +HG C+ Sbjct: 64 -AALHAEPNAAHRAVADLERR-GVPVRVLTQNVDGLHQLAGVSARKVLELHGTARDCVCT 121 Query: 120 QSGQVLDWTGDVTP----EDKCHCCQFPAPLRPHVVWFGEM--PLGMDEIYMALSMADIF 173 G + ED C L+ V FGE P+ + E +F Sbjct: 122 GCGARGPMADVLARIEAGEDDPPCLDCGGVLKTATVMFGERLDPVVLGEAAAISKACQVF 181 Query: 174 IAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 +A+GTS V PAAG A HGA V +N EP+ E P +P + L Sbjct: 182 VAVGTSLQVEPAAGLARVAVEHGARLVVVNAEPTPYDELADEVIREPIGSALPALLRGL 240 >UniRef50_C5CGD1 Silent information regulator protein Sir2 n=3 Tax=Thermotogaceae RepID=C5CGD1_KOSOT Length = 249 Score = 240 bits (614), Expect = 3e-62, Method: Composition-based stats. Identities = 74/240 (30%), Positives = 108/240 (45%), Gaps = 12/240 (5%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 E +LTGAG+S SGI FR GL+++ + + + F P R Sbjct: 16 ESESTAILTGAGVSTASGIPDFRGPQGLYKKL-PQYIFDLDFFLSQPAEYYKIAADRIHN 74 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 L E PNA H LA L+ G ++TQNID LH++AG+ VI +HG K C Sbjct: 75 LFNKE--PNATHRLLAMLEKK-GMIEGVITQNIDGLHQKAGSKKVIELHGNAQKFFCMSC 131 Query: 122 GQVLDWTG--DVTPEDKCHCCQFPAPLRPHVVWFGEMPL--GMDEIYMALSMADIFIAIG 177 G+ + C ++P VV+FGE M E Y+ A++FI +G Sbjct: 132 GKRYTAEDVLKMLEVSDVPKCTCGGLIKPDVVFFGEALPESAMAEAYILSENAELFITMG 191 Query: 178 TSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKGLK 237 +S VYPAA AK GA + +N + + +KY + EF E+++ L Sbjct: 192 SSLVVYPAAHLPTFAKQKGAKLLIINQGETGLDYIADKKYECD----LAEFSERIISLLG 247 >UniRef50_Q0AY57 Regulatory protein, sir2 family n=1 Tax=Syntrophomonas wolfei subsp. wolfei str. Goettingen RepID=Q0AY57_SYNWW Length = 253 Score = 240 bits (612), Expect = 4e-62, Method: Composition-based stats. Identities = 79/242 (32%), Positives = 118/242 (48%), Gaps = 11/242 (4%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEH---RVEDVATPEGFDRDPELVQAFYNARR 59 +V+TGAGIS E+GI FR +G++ + RV + + F +P FY R Sbjct: 15 SHNTVVVTGAGISTEAGIPDFRGPEGIYRKLGENRVMKIINIDFFRNNPLEFYKFY---R 71 Query: 60 RQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCS 119 + P ++P AH LA+++ A G +VTQNIDNLH++AG+ VI +HG + C Sbjct: 72 QYFIFPPVEPGKAHQVLAEMEKA-GIIKAIVTQNIDNLHQKAGSQKVIPIHGNGARFLCQ 130 Query: 120 Q--SGQVLDWTGDVT-PEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAI 176 + V D T PE C Q L+P VV FGE + + A + + I Sbjct: 131 ERNCRSVHDSNYVNTYPEVIPRCSQCGGILKPDVVLFGEHIKNYPDAMDRILGARVLVVI 190 Query: 177 GTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYY-GPASQVVPEFVEKLLKG 235 G+S VYP AGFV E + + +N P+ + + K G +++ E EK+ K Sbjct: 191 GSSLTVYPLAGFVKEFSTFTQYLIIINKGPTPLDHAAVVKLQEGNTGELLEEIFEKIKKR 250 Query: 236 LK 237 K Sbjct: 251 RK 252 >UniRef50_Q5WKC8 NAD-dependent deacetylase n=7 Tax=Bacillaceae RepID=NPD_BACSK Length = 237 Score = 239 bits (610), Expect = 8e-62, Method: Composition-based stats. Identities = 76/236 (32%), Positives = 113/236 (47%), Gaps = 9/236 (3%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 + R++V TGAG+S ESG+ FR++ GL + + E +A+ + + + E FY RRR Sbjct: 8 QAQRIVVFTGAGMSTESGVPDFRSSRGLCKGNNPEALASLQAMNDNREAFVDFY--RRRM 65 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 Q +QP+ + LA + L ++TQN D LHERAGN V+ +HG + K+ C Q Sbjct: 66 EQLQHVQPHKGYDVLATWEQQL-SVTAIITQNTDGLHERAGNQRVLPLHGSIQKLYCIQC 124 Query: 122 GQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMADIFIAIGTS 179 GQ D + + C +RP VV FGE + AD+FI +G+S Sbjct: 125 GQHYDVDRYMNNQPS---CSCGGFIRPSVVLFGEPLDSNILALAEQHSIEADVFIVLGSS 181 Query: 180 GHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKY-YGPASQVVPEFVEKLLK 234 V PA F AK HGA + +N + + + P + E L K Sbjct: 182 LVVSPANLFPRIAKEHGAKLIIVNHDSTPLDTIADYVVNDKPIGSFLVETNRALQK 237 >UniRef50_A9AWG1 Silent information regulator protein Sir2 n=3 Tax=Bacteria RepID=A9AWG1_HERA2 Length = 244 Score = 238 bits (609), Expect = 9e-62, Method: Composition-based stats. Identities = 93/233 (39%), Positives = 128/233 (54%), Gaps = 9/233 (3%) Query: 4 PRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQ 63 ++VLTGAGIS SG+R FR +G+W E +E AT ++ P+LV + R QLQ Sbjct: 11 RNIVVLTGAGISVASGVRPFRGPNGVWNEWDIERCATRTALEQSPQLVWQAFGPLRSQLQ 70 Query: 64 QPEIQPNAAHLALAKLQDALGD--RFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCS-- 119 QPNAAH ALA+ + +LG RF L+TQNID LH+ AG+ N++ HG L + RCS Sbjct: 71 --TTQPNAAHRALARFEQSLGKHQRFTLITQNIDGLHQLAGSRNLVEFHGSLRQSRCSDE 128 Query: 120 QSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDE--IYMALSMADIFIAIG 177 Q Q + C PLRP +V F E E +L D F+A+G Sbjct: 129 QCDQPSFVDQRAHTQTLPLCPTCGKPLRPDIVLFEEAIPVWAETQAKRSLRECDFFLAVG 188 Query: 178 TSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNE-FAEKYYGPASQVVPEFV 229 TSG V+PAA F A++ GA T+ +NLEP + F E+ G A +++P + Sbjct: 189 TSGTVFPAAAFARTAQMLGARTMLVNLEPHAADDSAFEEQQIGRAEELLPTLL 241 >UniRef50_C4QC33 Chromatin regulatory protein sir2, putative n=1 Tax=Schistosoma mansoni RepID=C4QC33_SCHMA Length = 305 Score = 238 bits (609), Expect = 1e-61, Method: Composition-based stats. Identities = 83/263 (31%), Positives = 119/263 (45%), Gaps = 34/263 (12%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 + VL TGAGISAES + TFR + W +D+ATP+ F +P LV FY+ R Sbjct: 42 KSHNVLAFTGAGISAESHVPTFRRSGESWRNFHTQDLATPDAFHSNPGLVWEFYHYCREV 101 Query: 62 LQQPEIQPNAAHLALAKLQDAL---GDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRC 118 ++ PNA HLALA + G F ++TQN+D LH +AG NV+ +HG L K RC Sbjct: 102 VRSR--CPNAGHLALAHAEKQYTECGRSFFIITQNVDGLHAKAGCVNVLELHGNLYKTRC 159 Query: 119 SQSGQ--------------------VLDWTGDVTPEDKCHCCQ-------FPAPLRPHVV 151 + + + P + CQ LRPHVV Sbjct: 160 LECNDIRVNFDKPICAALLGRGSPIIENIPCKPIPLSQLPRCQNRINNNICGGLLRPHVV 219 Query: 152 WFGEM--PLGMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQV 209 WFGE P + + + AD+ + +G S VYP A F G E+N+E + Sbjct: 220 WFGENLEPHILSKAGEIVQKADVCLVVGASSAVYPVASFTRSLANRGIPVAEINVEVTPA 279 Query: 210 GNEFAEKYYGPASQVVPEFVEKL 232 + + G + V+P+ + L Sbjct: 280 THLLQYHFQGKSGDVLPKLFDSL 302 >UniRef50_Q6BVM7 DEHA2C01386p n=4 Tax=Saccharomycetaceae RepID=Q6BVM7_DEBHA Length = 301 Score = 238 bits (607), Expect = 1e-61, Method: Composition-based stats. Identities = 83/291 (28%), Positives = 126/291 (43%), Gaps = 57/291 (19%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 M+ R++ L GAG+S SG+ TFR + GLW+ + D+ATP+ F DP LV FY+ RR Sbjct: 13 MKSKRIVALVGAGLSVSSGLPTFRGSQGLWKNFNMIDLATPDAFYIDPGLVWQFYSWRR- 71 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGN--TNVIHMHGELLKVRC 118 + + +PN HLALAKL F+ +TQN+D L RAG+ + +HG L +RC Sbjct: 72 -INASKAKPNKGHLALAKLSKLSNIEFMTITQNVDGLSIRAGHPKEKLHEIHGSLFDLRC 130 Query: 119 SQ--SGQV-----------------LDWTGDVTPE------------------------- 134 + V ++ Sbjct: 131 TSFMCNYVDHDNFKNPLTKALADTEFEYDKSGRKRKIIDETEVNKLSPQFAPVKQIPEEE 190 Query: 135 -DKCHCCQFPAPLRPHVVWFGEMPL----GMDEIYMALSMADIFIAIGTSGHVYPAAGFV 189 +C C+ + LRP VVWFGE + ++ D+ + IGTSG VYPA +V Sbjct: 191 LPQCPVCEDGSLLRPGVVWFGESLPLQTIDKIDNFIESDKIDLILVIGTSGTVYPANSYV 250 Query: 190 HEAKLHGAHTVELNLEPS----QVGNEFAEKYYGPASQVVPEFVEKLLKGL 236 KL G N + + + G A++++P ++ L+ L Sbjct: 251 DRIKLKGGKVAIFNTDIESEILNGEEKDTWGFQGDAAELLPIALKPLIGDL 301 >UniRef50_Q96EB6 NAD-dependent deacetylase sirtuin-1 n=36 Tax=Euteleostomi RepID=SIRT1_HUMAN Length = 747 Score = 238 bits (607), Expect = 2e-61, Method: Composition-based stats. Identities = 66/249 (26%), Positives = 104/249 (41%), Gaps = 25/249 (10%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEH--------RVEDVATPEGFDRDPELVQA 53 E +++VLTGAG+S GI FR+ DG++ + + E F +DP Sbjct: 252 ECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFK 311 Query: 54 FYNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGEL 113 F +++ + QP+ H +A L D G TQNID L + AG +I HG Sbjct: 312 F----AKEIYPGQFQPSLCHKFIA-LSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSF 366 Query: 114 LKVRCSQSGQVLDWT---GDVTPEDKCHCCQFP-----APLRPHVVWFGE-MPLGMDEIY 164 C +D GD+ + C + P A ++P +V+FGE +P Sbjct: 367 ATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAM 426 Query: 165 M-ALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQ 223 D+ I IG+S V P A + + H + +N EP + F + G Sbjct: 427 KYDKDEVDLLIVIGSSLKVRPVA-LIPSSIPHEVPQILINREPLPHLH-FDVELLGDCDV 484 Query: 224 VVPEFVEKL 232 ++ E +L Sbjct: 485 IINELCHRL 493 >UniRef50_B4VCV9 SIR2 family transcriptional regulator n=3 Tax=Actinomycetales RepID=B4VCV9_9ACTO Length = 241 Score = 237 bits (606), Expect = 2e-61, Method: Composition-based stats. Identities = 71/241 (29%), Positives = 105/241 (43%), Gaps = 11/241 (4%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAADGLWEE-HRVEDVATPEGFDRDPELVQAFYNARR 59 M KP V V +GAG+S +SGI +R GLW E + T E + DPE+ + + R Sbjct: 1 MGKPLVAVFSGAGMSTDSGIPDYRGPQGLWRRDPDAEKLVTYEYYMADPEIRRRSWRMRA 60 Query: 60 RQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELLKVR 117 ++ +PNAAH A+A+L D G ++TQN+D LH+ AG V +HG V Sbjct: 61 -EIGALGARPNAAHRAVAEL-DRGGTPVRVITQNVDGLHQLAGMPARKVFELHGTARSVL 118 Query: 118 CSQSGQVLDWTGDVTP----EDKCHCCQFPAPLRPHVVWFGEM--PLGMDEIYMALSMAD 171 C+ + E C L+ V FGE P + + Sbjct: 119 CTACHARSGMEEALARVAAGEPDPACLACGGILKSATVMFGERLDPQVLAQAVAVAKGCQ 178 Query: 172 IFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEK 231 +FIA+GT+ V PAA A GA + +N E + E P +P + + Sbjct: 179 VFIAVGTTLQVQPAASLAGMAATAGARLIIVNAEETPYDELADEVIREPIGTALPALLTR 238 Query: 232 L 232 + Sbjct: 239 I 239 >UniRef50_B3T8H4 Putative Sir2 family protein n=1 Tax=uncultured marine microorganism HF4000_APKG5H11 RepID=B3T8H4_9ZZZZ Length = 273 Score = 237 bits (605), Expect = 3e-61, Method: Composition-based stats. Identities = 69/235 (29%), Positives = 106/235 (45%), Gaps = 14/235 (5%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQ--AFYNAR 58 + V+VL GAG+S ESGI FR GLW ++ + F +DP+ F N Sbjct: 20 LSSSYVVVLAGAGLSVESGIPPFRGPGGLWTKYGEPTNLSYHEFTKDPKEWWEARFRNED 79 Query: 59 RR-------QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHG 111 R ++ + +PN H AL +++ A+G ++TQN+DNLH AG+ +++ +HG Sbjct: 80 RPGDPTYELKVAVDQARPNPGHHALVEME-AMGLLKCVITQNVDNLHREAGSNSLLEIHG 138 Query: 112 ELLKVRCSQSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMD---EIYMALS 168 +RC G G C Q ++ V FGE P+ D Sbjct: 139 NGTWLRCVGCGVRQPRDGYHFDSLPPICTQCGGVIKMDTVMFGE-PIPEDVLLASREQAE 197 Query: 169 MADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQ 223 D + +GTSG V PAA AK GA +E+N + + + GP+ + Sbjct: 198 ACDCMLLVGTSGTVNPAARLPLVAKELGATLIEINPDETTLTPSCDITLNGPSGE 252 >UniRef50_UPI0001C3128D Silent information regulator protein Sir2 n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C3128D Length = 256 Score = 236 bits (604), Expect = 3e-61, Method: Composition-based stats. Identities = 71/226 (31%), Positives = 97/226 (42%), Gaps = 10/226 (4%) Query: 3 KPRVLVLTGAGISAESGIRTFRAA-DGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 V+ LTGAGIS SGI FR GLW +VA + + D AFY R + Sbjct: 19 ARSVVALTGAGISVPSGIPDFRTPRTGLWANVDPMEVAHIDAWRNDAARFWAFYGHRFQS 78 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 L+ + +PN AH LA+L+ G ++TQNID LHERAG ++I +HG + C Sbjct: 79 LR--DKRPNRAHEVLAELERR-GIVETVITQNIDQLHERAGVADLIELHGSIAHSSCLAC 135 Query: 122 GQVLDWTGDVT----PEDKCHCCQFPAPLRPHVVWFGEMPL--GMDEIYMALSMADIFIA 175 G C PL+P VV FGE+ G++ AD+ + Sbjct: 136 GARYPLAEVQARLEQDPQGVPRCDCGRPLKPDVVLFGELLPQAGLERAQTLALRADLLLC 195 Query: 176 IGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPA 221 IG+S VYP G L P++ + K G Sbjct: 196 IGSSLEVYPVGELPSLTLRAGGEIAILTQGPTRYDRDAVVKLDGDI 241 >UniRef50_C6CZ67 Silent information regulator protein Sir2 n=1 Tax=Paenibacillus sp. JDR-2 RepID=C6CZ67_PAESJ Length = 239 Score = 236 bits (604), Expect = 3e-61, Method: Composition-based stats. Identities = 68/237 (28%), Positives = 116/237 (48%), Gaps = 8/237 (3%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEGFDRDPELVQAFYNARR 59 ++ ++ +GAG+S ESG++ FR+AD G+W ++A E D + E FY R Sbjct: 7 LDSSSTIIFSGAGMSTESGLQDFRSADRGMWNNRNPIELADIEAIDSNREEFIRFYQWRI 66 Query: 60 RQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCS 119 ++ QPN H LA ++ G ++TQN++N HE+AG + +HG+L + C Sbjct: 67 HEMNS--HQPNDGHRILADWENR-GLIKGIITQNVENYHEQAGTRQIAKLHGDLGTLHCM 123 Query: 120 QSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPL--GMDEIYMALSMADIFIAIG 177 + + + + PE K C +RP+VV FGEM + + ++FI +G Sbjct: 124 KCNKQYESKMYLVPE-KMTVCSCGGFIRPNVVLFGEMLRQSALQLANKLMKDVELFIVLG 182 Query: 178 TSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLK 234 +S V PA + AK +GA+ V +N +P+ + + ++ LLK Sbjct: 183 SSLQVSPANQYPKRAKENGANLVIINNDPTPADHYADIVINNSIGSSL-RMIDDLLK 238 >UniRef50_D0WS10 NAD-dependent deacetylase n=2 Tax=Actinomyces RepID=D0WS10_9ACTO Length = 245 Score = 236 bits (604), Expect = 4e-61, Method: Composition-based stats. Identities = 69/238 (28%), Positives = 112/238 (47%), Gaps = 13/238 (5%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHR---VEDVATPEGFDRDPELVQAFYNAR 58 + R++ GAG+S ESGI FR A+G + + R +E V + + F+ P+ ++ Sbjct: 14 QSNRIVFFGGAGVSTESGIPDFRGAEGFFHQDREIPIERVLSIDFFETHPQAYWEWFA-- 71 Query: 59 RRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRC 118 ++ + + PNAAH LA+L+ G +VTQNID LH+ AG+ + +HG ++ C Sbjct: 72 -QENAREGVAPNAAHRFLAELEKR-GSLSAVVTQNIDGLHQSAGSERIFELHGNWSRLLC 129 Query: 119 SQSGQVLDWT--GDVTPEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMADIFI 174 G+ + C +RP +V++GEM ++ A++ AD+ I Sbjct: 130 MGCGRRFSIADFDEARTGAVPRCPSCACVVRPDIVFYGEMLGSGVLEGAVRAIADADMLI 189 Query: 175 AIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 GTS VYPAAG V G V +N P+ + P +V E + Sbjct: 190 VAGTSLVVYPAAGLVDY--YDGDRLVLMNATPTPYDSRANLVIRDPVGKVFAELARAV 245 >UniRef50_Q8R984 NAD-dependent deacetylase 2 n=9 Tax=Thermoanaerobacter RepID=NPD2_THETN Length = 250 Score = 236 bits (604), Expect = 4e-61, Method: Composition-based stats. Identities = 67/230 (29%), Positives = 101/230 (43%), Gaps = 15/230 (6%) Query: 3 KPRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 + +VLTGAGIS ESGI FR+ GLWE +V + + PE FY + Sbjct: 20 SQKTMVLTGAGISTESGIPDFRSPGTGLWENMDPTEVLSTKVLFNSPE---EFYRVGFKI 76 Query: 62 LQQ-PEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 L +PN AH L++++ G ++TQNIDNLH++AG+ V +HG + C + Sbjct: 77 LSSMRNAEPNEAHYILSEME-KEGIIAGVITQNIDNLHQKAGSKKVYEVHGNTREGSCLR 135 Query: 121 SGQVLDW----TGDVTPEDKCHCCQFPAPLRPHVVWFGE-MPLGMDEIYMALSMADIFIA 175 G+ + + E C + LRP VV FG+ MP D + +D+ I Sbjct: 136 CGEKVSFELLEEKVAKEEIPPRCDRCGGMLRPDVVLFGDPMPHAFDLALKEVQESDLLIV 195 Query: 176 IGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVV 225 IG+S V P + +N + + AS + Sbjct: 196 IGSSLVVAPVNFLPGMVDG----LIIINATETPYDYKADVVIREKASYAL 241 >UniRef50_C1AAZ7 NAD-dependent deacetylase n=4 Tax=Bacteria RepID=C1AAZ7_GEMAT Length = 327 Score = 236 bits (604), Expect = 4e-61, Method: Composition-based stats. Identities = 87/246 (35%), Positives = 119/246 (48%), Gaps = 11/246 (4%) Query: 3 KPRVLVLTGAGISAESGIRTFRAA-DGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 V VLTGAGISAESGI TFR A GLW + +++ATP+ F P V +Y RR Sbjct: 86 AEHVCVLTGAGISAESGIPTFREAQTGLWAKFSPQELATPQAFASHPSRVWQWYAMRRAM 145 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 ++ QPN H AL L + +VTQN+D+LHER+G I +HG L+ +RCSQ Sbjct: 146 VRA--AQPNPGHAALLSLALRVAH-CTIVTQNVDDLHERSGVREPIRLHGSLMHIRCSQG 202 Query: 122 GQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPL--GMDEIYMALSMADIFIAIGTS 179 + + C Q +RP VVWFGE A D+F+++GTS Sbjct: 203 CAGSVPAPEEATAEVPKCPQCGGLMRPDVVWFGEGLPMGPFGAAREAAVACDVFLSVGTS 262 Query: 180 GHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFA---EKYYGPASQVVPEFVEKLLKGL 236 V PAA + HGA + +N P+ G GPA ++P + + G Sbjct: 263 NIVEPAASLPWISATHGATVIVVN--PTMEGQRKGPSILPIEGPAGVMLPRLIAEAFAGR 320 Query: 237 KAGSIA 242 + A Sbjct: 321 RPRRQA 326 >UniRef50_A9AWT4 Silent information regulator protein Sir2 n=1 Tax=Herpetosiphon aurantiacus ATCC 23779 RepID=A9AWT4_HERA2 Length = 243 Score = 236 bits (603), Expect = 5e-61, Method: Composition-based stats. Identities = 88/237 (37%), Positives = 130/237 (54%), Gaps = 12/237 (5%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAA--DGLWEEHRVEDVATPEGFDRDPELVQAFYNARR 59 + ++VLTG+GISA SGI T+R+A D W + + VAT GF+RDP V Y A + Sbjct: 14 QTQSLVVLTGSGISAPSGIPTYRSAAADARWTAYDPDKVATFAGFERDPVGVFQVYQAMK 73 Query: 60 RQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCS 119 RQ + QPNA H ALA+L+ LG +F L TQNID+LH+RAG++ V +HG L + CS Sbjct: 74 RQCEA--AQPNAGHYALAQLEQ-LGTQFKLFTQNIDSLHQRAGSSQVYEVHGSLARTICS 130 Query: 120 QSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMADIFIAIG 177 + G +++ P C APLRP +VWFGE+ + A +D+ + IG Sbjct: 131 REGNLVETWNAEQPI----CPACGAPLRPDIVWFGELLDAGILQAAKAAFDSSDVALVIG 186 Query: 178 TSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLK 234 TS V P A H A +E+N + + G A +++P+ ++++ K Sbjct: 187 TSAIVEPIASLPHRALRRKKTVIEINPDI-PLRGIATFSLAGSADELLPQLIKEVWK 242 >UniRef50_Q607X6 NAD-dependent deacetylase n=2 Tax=Gammaproteobacteria RepID=NPD_METCA Length = 255 Score = 236 bits (603), Expect = 5e-61, Method: Composition-based stats. Identities = 84/243 (34%), Positives = 116/243 (47%), Gaps = 13/243 (5%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAA-DGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 + + V TGAG+SAESGI TFR A G WE + +A+PEGF DP LV +Y RR Sbjct: 13 DARHIAVFTGAGVSAESGIPTFRDALTGFWENYDASTLASPEGFAADPALVWGWYEWRRT 72 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 ++ + E P + A R L+TQN+D+LHERAG+ + I +HG L RCS Sbjct: 73 RVLRAEPNPAHYAI---AALAADCPRLTLITQNVDDLHERAGSADPIRLHGSLHHPRCSA 129 Query: 121 SGQVLDWTGDVTPE-------DKCHCCQFPAPLRPHVVWFGEMPL--GMDEIYMALSMAD 171 + E D C + AP+RP VVW GE D A D Sbjct: 130 CEAPYRLPPGIPDEPEGGRRVDPPRCARCGAPVRPGVVWLGENLPQAAWDAARQAAEDCD 189 Query: 172 IFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEK 231 + +IGTS V+PAA GA V++N + + G A +V+P ++ Sbjct: 190 LMFSIGTSALVWPAAQLPALVARRGATVVQVNPAETALDGHAGYNLRGAAGKVMPLLLQA 249 Query: 232 LLK 234 L + Sbjct: 250 LRR 252 >UniRef50_D2VWA2 Silent information regulator family protein n=1 Tax=Naegleria gruberi RepID=D2VWA2_NAEGR Length = 297 Score = 236 bits (602), Expect = 6e-61, Method: Composition-based stats. Identities = 84/260 (32%), Positives = 125/260 (48%), Gaps = 24/260 (9%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWE----EHRVEDVATPEGFDRDPELVQAFYNA 57 + RV+V +GAG+SAESGI TFR GLW + + TP G++ P++ Y Sbjct: 25 KARRVVVFSGAGMSAESGIDTFRGGGGLWTGLMGKLFLAYGGTPFGWNITPQICWGQY-I 83 Query: 58 RRRQLQQPEIQPNAAHLALAKLQDA-LGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKV 116 +R + PN H ALAKL+ GD ++TQN+D LH+RAG+T+V +HG +++ Sbjct: 84 KRFYGPIAKADPNNGHFALAKLEQEVFGDYMEVITQNVDGLHQRAGSTHVYEVHGTVMRH 143 Query: 117 RCSQSGQVLDWTGDVTPE------------DKCHCCQFPAPLRPHVVWFGE-MPLGMDE- 162 C + D+ E KC + LRP V F E +P+ E Sbjct: 144 CCIAERHIFDFDEYWGEENDEKKMDLPDKSPKCKHPGCNSTLRPDCVLFTEALPMDQWEP 203 Query: 163 ---IYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYY- 218 + D+ I +GTS VYPAA A GAH +E NLE + + Sbjct: 204 SFHAVDRMRKGDVMICVGTSAKVYPAASLPGRAARRGAHLIEFNLEETDYNQLPNYIFVK 263 Query: 219 GPASQVVPEFVEKLLKGLKA 238 GP+ Q +P V+++++ A Sbjct: 264 GPSGQTLPTIVDRVIELRNA 283 >UniRef50_C6AKY4 Transcriptional regulator, Sir2 family n=5 Tax=Proteobacteria RepID=C6AKY4_AGGAN Length = 232 Score = 235 bits (601), Expect = 7e-61, Method: Composition-based stats. Identities = 101/237 (42%), Positives = 136/237 (57%), Gaps = 10/237 (4%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 KP +VL+GAGISAESGI T+RA DGLW H++E+V TPE R+ + V FYN RRR Sbjct: 2 KPLCVVLSGAGISAESGIPTYRAEDGLWAGHKIEEVCTPEALQRNRKKVLDFYNERRRNC 61 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG 122 QPNAAH AL +L+ G ++TQN+D+LHERAG+ NV+H+HGEL K R SG Sbjct: 62 SA--AQPNAAHKALVELEQ--GYNVQIITQNVDDLHERAGSANVLHLHGELNKAR---SG 114 Query: 123 QVLDWTGDVTPEDKCHCCQFPA-PLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGH 181 D+ E P+RPH+V+FGE ++ +S AD+ + IGTS Sbjct: 115 FDPDYIVPCFGEQSVDDKDPNGHPMRPHIVFFGENVPMLEPAIDLVSQADVVLVIGTSLQ 174 Query: 182 VYPAAGFVHEAKLHGAHTVELNLEP-SQVGNEFAEKYYGPASQVVPEFVEKLLKGLK 237 VYPA G V+EA + A ++ P + E A + VP+ V +LL +K Sbjct: 175 VYPANGLVNEAPKN-AQIYLIDPNPNTGFIPRPVETVKMKAGEGVPKVVAELLGKVK 230 >UniRef50_Q8A3H9 NAD-dependent deacetylase n=29 Tax=Bacteria RepID=NPD_BACTN Length = 234 Score = 235 bits (601), Expect = 8e-61, Method: Composition-based stats. Identities = 98/241 (40%), Positives = 134/241 (55%), Gaps = 18/241 (7%) Query: 4 PRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQ 63 ++VLTGAG+SAESGI TFR A GLW+++ VE VATPEG+ RDP LV FYNARR+QL Sbjct: 2 KNLVVLTGAGMSAESGISTFRDAGGLWDKYPVEQVATPEGYQRDPALVINFYNARRKQLL 61 Query: 64 QPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQ 123 E++PN H LA+L+ ++TQN+DNLHERAG+++++H+HGEL KV Sbjct: 62 --EVKPNRGHELLAELEK--NFNVTVITQNVDNLHERAGSSHIVHLHGELTKV----CSS 113 Query: 124 VLDWTGDVTPEDKCH--------CCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIA 175 + E K LRP +VWFGE ++ + ADIF+ Sbjct: 114 RDPYNPHYIKELKPEEYEVKMGDKAGDGTQLRPFIVWFGEAVPEIETAVRYVEKADIFVI 173 Query: 176 IGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQV-GNEFAEKYYGPASQVVPEFVEKLLK 234 IGTS +VYPAAG +H GA ++ +P + AS+ V E + L+ Sbjct: 174 IGTSLNVYPAAGLLHYVP-RGAEVYLIDPKPVDTHTSRSIHVLRKGASEGVEELKQLLIP 232 Query: 235 G 235 Sbjct: 233 A 233 >UniRef50_A6TNA0 Silent information regulator protein Sir2 n=2 Tax=Clostridiales RepID=A6TNA0_ALKMQ Length = 249 Score = 235 bits (601), Expect = 9e-61, Method: Composition-based stats. Identities = 72/234 (30%), Positives = 97/234 (41%), Gaps = 10/234 (4%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 + ++LTGAG+ ES I FR+ G W VA + F + L FY+ R R Sbjct: 23 KSKDTVILTGAGMDTESNIPDFRSEKGWWRSIDPRTVANIDTFYENYSLFHEFYDMRLRL 82 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 L IQP+ H L+ L+ G + TQN+ LH AG+ NV +HG + K+RC+ Sbjct: 83 LV--GIQPHKGHYILSDLEKK-GMIRSIATQNVAGLHVMAGSQNVYELHGNIRKIRCNNC 139 Query: 122 GQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEM--PLGMDEIYMALSMADIFIAIGTS 179 + C C LRP V+ FGE P D + D+ I IGTS Sbjct: 140 NHEASL-ERFLAVETCGSCGDKG-LRPSVILFGETLPPKAWDSALRDIQKCDLLIVIGTS 197 Query: 180 GHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLL 233 VYP K V +N E F G A +V+ LL Sbjct: 198 LEVYPVNHLPMLTK---GKKVFINNEERSTDYAFDLTIIGKAKEVLEALNHYLL 248 >UniRef50_Q1QTH0 Silent information regulator protein Sir2 n=3 Tax=Bacteria RepID=Q1QTH0_CHRSD Length = 242 Score = 235 bits (600), Expect = 1e-60, Method: Composition-based stats. Identities = 101/230 (43%), Positives = 137/230 (59%), Gaps = 5/230 (2%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 + P ++VLTGAGISAESG++TFR DGLWE HRV+DVATPE F RDPE V FY+ARR Q Sbjct: 5 QGPHLVVLTGAGISAESGLKTFRDGDGLWENHRVQDVATPEAFARDPETVLRFYDARREQ 64 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 + PNAAH ALA+L+ A G + ++TQNID+LHERAG+ +V+H+HGE+L R S + Sbjct: 65 --TRQATPNAAHRALAELEQA-GFQVSVITQNIDDLHERAGSRDVLHLHGEILMSR-SSA 120 Query: 122 GQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGH 181 L + C + LRP VVWFGE + ++ AD+ + +GTS Sbjct: 121 DPNLRYPVGRKGIRLGDLCDKGSQLRPDVVWFGEPVPRYAQACEIVAEADLVLVVGTSLA 180 Query: 182 VYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEK 231 V PAA + +A + A + ++ + + ASQ VP VE Sbjct: 181 VMPAAMLLDQAPIE-APCLLVDPQAESLVPRGVRAISQLASQGVPPLVEH 229 >UniRef50_B8FEP4 Silent information regulator protein Sir2 n=1 Tax=Desulfatibacillum alkenivorans AK-01 RepID=B8FEP4_DESAA Length = 252 Score = 235 bits (599), Expect = 1e-60, Method: Composition-based stats. Identities = 71/237 (29%), Positives = 110/237 (46%), Gaps = 12/237 (5%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 E R + TGAGIS ESGI FR+ G+W+++R + F + +++ + Sbjct: 14 EGGRNIAFTGAGISTESGIPDFRSQGGIWDQYRP---VYFDEFMSSRDARVRYWDQKIAM 70 Query: 62 LQQPE-IQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGN--TNVIHMHGELLKVRC 118 E +PNA H ALAKL D +G ++TQNID LH+ +G VI +HG +VRC Sbjct: 71 WDGLEKARPNAGHQALAKLYD-MGLLEAIITQNIDGLHQESGIPGDKVIELHGNTRRVRC 129 Query: 119 SQSGQ---VLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGE-MP-LGMDEIYMALSMADIF 173 G+ V + + D C L+P + FG+ MP ++ S D F Sbjct: 130 MTCGETSTVAEAKQRILDGDPAPECHCGGYLKPDTISFGQAMPQKEVEAAARLSSSCDFF 189 Query: 174 IAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVE 230 + +G++ V+PAA A+ GA+ +NL + N A V+ + Sbjct: 190 LVVGSTLVVHPAAMMPEYARRAGAYLAIVNLSDTPYDNACQALVREKAGPVLQAIAD 246 >UniRef50_Q73KE1 NAD-dependent deacetylase n=2 Tax=Treponema RepID=NPD_TREDE Length = 251 Score = 235 bits (599), Expect = 1e-60, Method: Composition-based stats. Identities = 65/239 (27%), Positives = 108/239 (45%), Gaps = 11/239 (4%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 + ++ TGAGIS +GI+ FR DGL+++ E + + F RDP + +Y + Sbjct: 17 KARHLVAFTGAGISTLAGIKDFRGKDGLYKQPNTEKMFDIDVFYRDPSV---YYGMAKEF 73 Query: 62 LQ-QPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 + E QP H LA L+ G ++TQNID LH++AG+ NVI +HG C Sbjct: 74 IYGLEEKQPAIVHTVLADLEKR-GILKAVITQNIDLLHQKAGSKNVIEVHGSPSVHYCIN 132 Query: 121 SGQVLDWT---GDVTPEDKCHCCQFPAPLRPHVVWFGEMPL--GMDEIYMALSMADIFIA 175 + + C + +P++P + +FGE + + S +D + Sbjct: 133 CSYTETFEETAKTAKTGEVPRCPKCGSPIKPAITFFGEALPQKALMKAETEASKSDFMLV 192 Query: 176 IGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLK 234 +GTS VYPAA +G +N +P+Q + + + E ++L K Sbjct: 193 LGTSLLVYPAAALPAYTLRNGGKIAIVNNQPTQFDSYTDLLF-EDLEETFEEIDKRLKK 250 >UniRef50_UPI000179269F PREDICTED: similar to sirtuin n=1 Tax=Acyrthosiphon pisum RepID=UPI000179269F Length = 583 Score = 234 bits (597), Expect = 2e-60, Method: Composition-based stats. Identities = 61/246 (24%), Positives = 99/246 (40%), Gaps = 23/246 (9%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEH--------RVEDVATPEGFDRDPELVQAF 54 R++VLTGAG+S GI FR+ +G++ + + + F +DP F Sbjct: 203 SNRIMVLTGAGVSVSCGIPDFRSHNGVYARLATEFPDLPDPQSMFCIDYFSKDPRPFFKF 262 Query: 55 YNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELL 114 R++ + +P+ +H + L+ G TQNID L + G NVI HG Sbjct: 263 ----AREIYPGQFKPSPSHQFIKVLEKK-GRLLRNYTQNIDTLEQVVGINNVIECHGSFA 317 Query: 115 KVRCSQSGQVLDWTGDVTPE-----DKCHCC-QFPAPLRPHVVWFGE-MPLGMDEIYM-A 166 C+Q G + +C C ++P +V+FGE +P + Sbjct: 318 TASCTQCGHKVSAETIRPDVFEQRIPRCPICVNSTGIMKPDIVFFGEGLPDSFHKAIEDD 377 Query: 167 LSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVP 226 + D+ I IG+S V P A + H + +N E N F + G + +V Sbjct: 378 KNNCDLLIVIGSSLKVRPVARIPNMLDKH-VPQILINRERLPHMN-FDVELLGDSDVIVD 435 Query: 227 EFVEKL 232 L Sbjct: 436 HLCRML 441 >UniRef50_C3IUP0 SIR2 n=2 Tax=Bacillus thuringiensis RepID=C3IUP0_BACTU Length = 241 Score = 234 bits (597), Expect = 2e-60, Method: Composition-based stats. Identities = 71/237 (29%), Positives = 114/237 (48%), Gaps = 11/237 (4%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 + ++VLTGAGIS +SG+ +R+ GLW+ + E+++ + PE V+ F + R Sbjct: 11 KSNHIVVLTGAGISTDSGLPDYRSNGGLWDGKKPEEISHFSAVGK-PEFVKFFAD---RM 66 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 +PN AH LAK ++ G ++TQNID+ H+ AG+ NVI MHG L + C Sbjct: 67 NDISNCKPNKAHEILAKWEEQ-GKVKSVITQNIDSYHKDAGSKNVIEMHGHLRNLVCDTC 125 Query: 122 GQVLDWTGDVTPEDKCHC---CQFPAPLRPHVVWFGEM--PLGMDEIYMALSMADIFIAI 176 + D T EDK +C + +RP VV FGE PL + + D+ I + Sbjct: 126 SKEYD-NSMYTKEDKDNCGLEWECTGVVRPEVVLFGETLPPLAWHQANEQMKKTDLVIVL 184 Query: 177 GTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLL 233 GTS V+P V A + + + + + + Y ++ + E +L Sbjct: 185 GTSLQVFPFNSLVESVYPGKAPVMIITKSDTPYDHMASVRIYDNITETLVEIDNRLK 241 >UniRef50_A5UYK2 Silent information regulator protein Sir2 n=2 Tax=Roseiflexus RepID=A5UYK2_ROSS1 Length = 261 Score = 233 bits (596), Expect = 3e-60, Method: Composition-based stats. Identities = 74/230 (32%), Positives = 104/230 (45%), Gaps = 9/230 (3%) Query: 7 LVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQ-P 65 + +TGAGIS SGI FR DG W+ +VA+ F R+P +AFY+ R L + Sbjct: 25 VAITGAGISTPSGIPDFRGPDGAWKHVDPSEVASLHNFLRNP---RAFYDWFRPLLDRVL 81 Query: 66 EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVL 125 PNAAH ALA L+ ++TQN D LH+RAG+ V +HG L C + + + Sbjct: 82 AAAPNAAHYALAALEQHR-TLRAIITQNFDGLHQRAGSREVYELHGHLRTATCLECERQI 140 Query: 126 DWTG--DVTPEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMADIFIAIGTSGH 181 + C PL+P VV F EM A+ AD+ I GTS Sbjct: 141 PTQALLPRIRRGEPPRCSCGHPLKPDVVLFDEMLPRGLYWLARRAVEHADVIIVAGTSLE 200 Query: 182 VYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEK 231 V+P HGA + +N P+ + G + +PE V + Sbjct: 201 VFPVNDLPALGLRHGAKLIIINNGPTYLDGRAEAVIRGDVAIALPELVRQ 250 >UniRef50_Q1RPU3 Zinc finger protein (Fragment) n=1 Tax=Ciona intestinalis RepID=Q1RPU3_CIOIN Length = 737 Score = 233 bits (596), Expect = 3e-60, Method: Composition-based stats. Identities = 62/247 (25%), Positives = 102/247 (41%), Gaps = 24/247 (9%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEH--------RVEDVATPEGFDRDPELVQAF 54 ++LVLTGAG+S GI FR+ DG++ + + F DP F Sbjct: 188 SKKILVLTGAGVSVSCGIPDFRSRDGIYSRLSVDFPDLPNPQAMFDIHYFKHDPRPFFKF 247 Query: 55 YNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELL 114 +++ + +P+ AH ++ L+ G TQNID L + AG + V+ HG Sbjct: 248 ----AKEIYPGQFKPSRAHRFISLLE-KTGRLLRNYTQNIDTLEQVAGISKVVQCHGSFA 302 Query: 115 KVRCSQSGQVL---DWTGDVTPEDKCHCCQF----PAPLRPHVVWFGE-MPLGMDE-IYM 165 C + D+ + HC + P ++P +V+FGE +P + Sbjct: 303 TASCCSCDYKTNCEELRADIFNQVVPHCPRCPSDDPGVIKPDIVFFGENLPQQFHRQMTS 362 Query: 166 ALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVV 225 AD+ I IG+S V P A + H + +N EP F + G ++ Sbjct: 363 DKDDADLLIVIGSSLKVRPVALIPNSIPDH-IPQLLINREPLSH-MTFDIELLGDCDVIL 420 Query: 226 PEFVEKL 232 E ++L Sbjct: 421 SEISKRL 427 >UniRef50_B0S0T6 Transcriptional regulator Sir2 family n=4 Tax=Clostridiales Family XI. Incertae Sedis RepID=B0S0T6_FINM2 Length = 246 Score = 233 bits (595), Expect = 4e-60, Method: Composition-based stats. Identities = 65/231 (28%), Positives = 106/231 (45%), Gaps = 14/231 (6%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEE-----HRVEDVATPEGFDRDPELVQAFYN 56 + +++ GAG+S SGI FR+A GL+ + E + + E F P+L Q + Sbjct: 13 QSDKIVFFGGAGVSTASGIPDFRSATGLYNKKNDSDFSPEYMLSHEFFVTHPDLFQDY-- 70 Query: 57 ARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKV 116 L ++PN AHL+L KL+ A ++TQNID+L AG N+ +HG L Sbjct: 71 -VLENLIIDGVKPNNAHLSLRKLEKA-NKLLGVITQNIDSLDTMAGTKNIAEIHGNLRDY 128 Query: 117 RCSQSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPL--GMDEIYMALSMADIFI 174 C G D C C + +RP V +GE+P + ++ AD I Sbjct: 129 YCVNCGAKYDLDYYKQNRP-CKCEKCGGVVRPDVTLYGEVPPQSEFAKAINWINKADTMI 187 Query: 175 AIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVV 225 G+S VYPA+G ++ G + + +NL+ + N + ++ + Sbjct: 188 VAGSSLVVYPASGLINYF--RGDNLILINLDRTSYDNMANIVIHDDIAKTL 236 >UniRef50_A9A0B2 NAD-dependent deacetylase n=1 Tax=Desulfococcus oleovorans Hxd3 RepID=NPD_DESOH Length = 273 Score = 233 bits (595), Expect = 4e-60, Method: Composition-based stats. Identities = 80/261 (30%), Positives = 118/261 (45%), Gaps = 27/261 (10%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGF----DRDPELVQAFYNAR 58 R V +GAG+SAESGI TFR G+W+ +V +G +++PE + A + Sbjct: 17 ASRAAVFSGAGVSAESGIPTFRDPGGVWDRLNPAEVGDTQGLLASLEKNPEKLVAMFMEL 76 Query: 59 RRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRC 118 PN H AL L+ +G ++TQNIDNLH+ AGNT VI MHG + RC Sbjct: 77 LAVFDA--AIPNPGHRALFDLER-MGILQAVITQNIDNLHQEAGNTQVIEMHGNGFRFRC 133 Query: 119 SQSGQVL-------------------DWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLG 159 + D++ C + +RP VV FGE + Sbjct: 134 LKCRSRRSHERHALIGRVKERLSTLPDFSPASIFAAMPDCDLCGSGMRPDVVMFGETVME 193 Query: 160 MDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYG 219 ++ + A D+ +A+GTSG V PAA EAK GA + +N + Sbjct: 194 VENAFAAARSCDVMLALGTSGVVTPAAQIPAEAKASGAKVIVINPNENGFARVCDIYISM 253 Query: 220 PASQVVPEFVEKLLKGLKAGS 240 Q +P VE++ K +++GS Sbjct: 254 KTGQALPRIVEQV-KKIRSGS 273 >UniRef50_Q89LY4 NAD-dependent deacetylase 1 n=18 Tax=Proteobacteria RepID=NPD1_BRAJA Length = 254 Score = 233 bits (594), Expect = 5e-60, Method: Composition-based stats. Identities = 76/236 (32%), Positives = 106/236 (44%), Gaps = 12/236 (5%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNAR-RR 60 E ++ TGAGIS E GI FR+ G+W +R +GF E + R Sbjct: 21 EAKTIVPFTGAGISTECGIPDFRSPGGIWTRNRPIPF---DGFVASQEARDESWRRRFAM 77 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELLKVRC 118 + +P H ALA L A G ++TQNIDNLH+ +G + +VI +HG RC Sbjct: 78 EETFAAARPGRGHRALASLYRA-GKVPAVITQNIDNLHQASGFAHEHVIELHGNTTYARC 136 Query: 119 SQSGQVL--DWTGDVTPEDKCHCCQ-FPAPLRPHVVWFGEM--PLGMDEIYMALSMADIF 173 GQ DW +D C P++ + FG+M M D+F Sbjct: 137 VGCGQTYQLDWVKRRFDQDGAPNCTVCDEPVKTATISFGQMMPEEEMQRATALSRACDLF 196 Query: 174 IAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFV 229 IAIG+S V+PAAGF AK GA V +N EP++ + + + FV Sbjct: 197 IAIGSSLVVWPAAGFPMMAKRAGARLVIINREPTEQDDIADLVIRHDIGETLGPFV 252 >UniRef50_B0EBU9 NAD-dependent deacetylase, putative n=3 Tax=Entamoeba RepID=B0EBU9_ENTDI Length = 362 Score = 232 bits (592), Expect = 9e-60, Method: Composition-based stats. Identities = 66/239 (27%), Positives = 116/239 (48%), Gaps = 10/239 (4%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 V+VLTGAGIS +GI FR+ +G+W+ + + + E F + PE+ + R+ Sbjct: 27 SKHVVVLTGAGISVSAGIPDFRSRNGMWKRYEPKIYGSYENFIKRPEMFWKMCSELRK-- 84 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG 122 +P AH AL KL++ ++ TQN+DNLH+ AG+ V +HG +C + G Sbjct: 85 YTEGKKPTKAHFALRKLEEIGKIEEII-TQNVDNLHQLAGSRKVNELHGTGKICQCIKCG 143 Query: 123 QVLDWT-----GDVTPEDKCHCCQFPAPLRPHVVWFG--EMPLGMDEIYMALSMADIFIA 175 + G + D C + ++ VV FG ++ + S++D+F+ Sbjct: 144 YRGNADVILPKGLIPWIDIPKCPKCGGLIKLDVVLFGEELEKEKFEKAFEVASISDVFLV 203 Query: 176 IGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLK 234 IG+S V PA +AK++ A +N ++ N G + ++P+ VE +++ Sbjct: 204 IGSSLEVMPANALPRKAKMNSATVAYINKTITRFDNYADYVIRGESDYLIPKIVEYVIE 262 >UniRef50_D1N1D6 Silent information regulator protein Sir2 n=1 Tax=Victivallis vadensis ATCC BAA-548 RepID=D1N1D6_9BACT Length = 248 Score = 231 bits (591), Expect = 1e-59, Method: Composition-based stats. Identities = 67/226 (29%), Positives = 107/226 (47%), Gaps = 13/226 (5%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGL----WEEHRVEDVATPEGFDRDPELVQAFYNA 57 E R L TGAGIS SGIR FR +G+ W VE++ + + F +P L FY Sbjct: 11 ESRRTLAFTGAGISTLSGIRDFRGKNGVYLEPWHGKSVEEILSLDCFLAEPAL---FYGW 67 Query: 58 RRRQLQQPE-IQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKV 116 L + E P A H ALA L+ + G + TQNID LH++AG+ +V +HG + Sbjct: 68 AAEFLYRLEEFHPAAVHRALAGLEQS-GLLRGVYTQNIDLLHQQAGSRHVYELHGSPARH 126 Query: 117 RCSQSGQVLDWTGDVTPE--DKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMADI 172 C + + + K C ++P +V++GE +++ + + A++ Sbjct: 127 HCLKCRKQFGYAEIAPLVLAGKVPRCGCGGLVKPDIVFYGENLDEALLNQAFADMEKAEL 186 Query: 173 FIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYY 218 + +G+S V PAA A G V +N +P+ + A +Y Sbjct: 187 VLVLGSSLTVQPAASLPMAANYGGGKIVIVNAQPTPLDRYAALRYD 232 >UniRef50_C1SNI0 NAD-dependent protein deacetylase, SIR2 family n=1 Tax=Denitrovibrio acetiphilus DSM 12809 RepID=C1SNI0_9BACT Length = 256 Score = 231 bits (591), Expect = 1e-59, Method: Composition-based stats. Identities = 64/235 (27%), Positives = 103/235 (43%), Gaps = 12/235 (5%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 + P + TGAG S ESGI +R+ GLW + + +GF +P + FY Sbjct: 18 DNPYNVFFTGAGASTESGIPDYRSEGSGLWNRIDSSKLISLKGFLENP---KGFYEVFSG 74 Query: 61 QLQQP--EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRC 118 L P +PN AH+ +A L++ + ++TQNID LH +AG+ N+ +HG + C Sbjct: 75 GLFAPFAHAEPNVAHMFIAMLEEQKASK-AVITQNIDGLHRKAGSFNICELHGSMETSSC 133 Query: 119 SQSGQVLDWTG---DVTPEDKCHCCQFPAPLRPHVVWFGE-MPLG-MDEIYMALSMADIF 173 G+ + C ++P +V+FGE +P ++E + + + Sbjct: 134 IICGKSFSTAEVFDKFMLDGATPECTCGNIVKPDIVFFGESLPKDVLEESFELAAGCTLM 193 Query: 174 IAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEF 228 I G+S V PA AK HGA V +N + + +V E Sbjct: 194 IVAGSSLEVMPANLLPKYAKDHGALLVIINKTETPLDYTADIVINKGIGEVFTEL 248 >UniRef50_Q12Y78 NAD-dependent deacetylase, Sir2-like n=1 Tax=Methanococcoides burtonii DSM 6242 RepID=Q12Y78_METBU Length = 245 Score = 231 bits (590), Expect = 2e-59, Method: Composition-based stats. Identities = 62/228 (27%), Positives = 108/228 (47%), Gaps = 11/228 (4%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 +VLTGAG+S SGI FR G++ + + + + + F++DP FY + + Sbjct: 11 SEYCVVLTGAGVSTFSGIPDFRGRSGVYNKFDADLIFSIDHFNKDPAY---FYAHSKSFI 67 Query: 63 QQPEI-QPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 E QP+ H L+KL++ G ++TQNID LH++AG+ NVI +HG + C Sbjct: 68 YDLEHRQPSIVHSVLSKLEEK-GIIKAIITQNIDMLHQKAGSKNVIEVHGSPQEHVCLAC 126 Query: 122 GQVLDWTGDV---TPEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMADIFIAI 176 G+ + E C + ++P +V++GEM +++ S AD+ + + Sbjct: 127 GKKYSYEYIAELLKAEGFPLCNECGGLVKPDIVFYGEMLRQDTIEKAIQESSKADLMLVL 186 Query: 177 GTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQV 224 G++ V PAA +G V +N + + ++ Y V Sbjct: 187 GSTLVVQPAASLPLYTIENGGELVIVNDMKTPLDGYA-KRLYDDLGDV 233 >UniRef50_UPI0001757F4E PREDICTED: similar to NAD-dependent deacetylase sirtuin-1 (SIR2alpha) (mSIR2a) (Sir2) (SIR2-like protein 1) n=1 Tax=Tribolium castaneum RepID=UPI0001757F4E Length = 695 Score = 230 bits (587), Expect = 3e-59, Method: Composition-based stats. Identities = 61/252 (24%), Positives = 98/252 (38%), Gaps = 21/252 (8%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEH--RVEDVATPEG------FDRDPELVQAF 54 ++VLTGAG+S GI FR+ DG++ D+ P+ F +DP F Sbjct: 211 AQNIIVLTGAGVSVSCGIPDFRSRDGIYVRLAIDFPDLPDPQAMFDISYFSQDPRPFFKF 270 Query: 55 YNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELL 114 R + + P+ H + L++ G TQNID L + A VI HG Sbjct: 271 ----ARDIYPGKFTPSPCHRFIKMLEN-YGKLLRNYTQNIDTLEKVANIEKVIECHGSFA 325 Query: 115 KVRCSQSGQVLDWTGDV---TPEDKCHCCQFPAPLRPHVVWFGE-MPLGMDEI-YMALSM 169 C++ G + + C + ++P +V+FGE +P E + Sbjct: 326 TATCTKCGHKVTADAIREIVLAQQIPLCEKCQGIMKPDIVFFGEGLPDTFHEAMAQDKTE 385 Query: 170 ADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFV 229 D+ + IG+S V P A H + +N EP + F + G +V Sbjct: 386 CDLLLVIGSSLKVRPVALIPSSLPPH-VPQILINREPLPHCH-FDVELLGDCDVIVNHLC 443 Query: 230 EKLLKGLKAGSI 241 L G+ + Sbjct: 444 -HLFGGVWKEGV 454 >UniRef50_A8NWP2 Putative uncharacterized protein n=1 Tax=Coprinopsis cinerea okayama7#130 RepID=A8NWP2_COPC7 Length = 315 Score = 230 bits (586), Expect = 5e-59, Method: Composition-based stats. Identities = 87/286 (30%), Positives = 124/286 (43%), Gaps = 61/286 (21%) Query: 3 KPRVLVLTGAGISAESG----------------IRTFRAADGLWEEHRVEDVATPEGFDR 46 ++ + GAG+SA SG I TFR A G+W ++ +ATPEGF Sbjct: 16 AKNIIAVAGAGLSAASGKSGYYRFKWNLTTSQGIPTFRGAGGMWRKYDAMSLATPEGFAD 75 Query: 47 DPELVQAFYNARRRQLQQPEIQPNAAHLALAKLQ-------DALGDRFLLVTQNIDNLHE 99 +P LV FY+ RR + ++ NAAHLALA A G F L+TQN+D L Sbjct: 76 NPSLVWQFYHYRREAALKADV--NAAHLALASFSIPRIRHTVAPGSSFTLITQNVDGLSP 133 Query: 100 RA------GNTNV---------IHMHGELLKVRCSQSGQV-------------------- 124 RA G V I MHG L V+C+Q V Sbjct: 134 RAMKCVLQGWDGVTLPEDPPYLIEMHGRLFDVKCTQCDHVELDTSSPICEGLAGTEKLVE 193 Query: 125 -LDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGHVY 183 ++ E+ C + + RP VVWFGEMP + I + AD+ + +GTS VY Sbjct: 194 QAVLDPEIPEENLPRCKKCGSLARPGVVWFGEMPHDLPLIDTLVEKADLCLVVGTSSTVY 253 Query: 184 PAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFV 229 PAAG+ E +G N E + ++ + G + +P+ + Sbjct: 254 PAAGYASEVSANGGKVAVFNYERTMGDDDADFLFLGGCEETLPKAL 299 >UniRef50_Q3V7G9 NAD-dependent deacetylase (Regulatory protein sirtuin family) n=11 Tax=Acinetobacter RepID=Q3V7G9_ACIAD Length = 233 Score = 230 bits (586), Expect = 5e-59, Method: Composition-based stats. Identities = 90/198 (45%), Positives = 121/198 (61%), Gaps = 12/198 (6%) Query: 4 PRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQ 63 +++V +GAG+SAESGI TFR DGLWE +R+E+VATPE + ++P LVQ FYN RR+ + Sbjct: 2 KKLVVFSGAGMSAESGIHTFRDHDGLWENYRIEEVATPEAWQQNPSLVQHFYNERRKNIL 61 Query: 64 QPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQ 123 QPN AH +A+L+ ++TQNID+LHERAG+T+V+H+HG + + SG Sbjct: 62 A--AQPNLAHQIIAQLESCYQ--VQVITQNIDDLHERAGSTHVLHLHGNIRLAK--SSGP 115 Query: 124 VLDWTGDVTPEDKCH------CCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIG 177 +T P D C PLRPHVVWFGE D+ L AD+FI IG Sbjct: 116 NAQFTQTFYPIDGWQLDLNQDKCNEGYPLRPHVVWFGEAVPAYDDAIAMLKDADVFIVIG 175 Query: 178 TSGHVYPAAGFVHEAKLH 195 ++ VYP AG +HE H Sbjct: 176 STLSVYPVAGLIHEIPNH 193 >UniRef50_D1B8J6 Silent information regulator protein Sir2 n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B8J6_THEAS Length = 246 Score = 229 bits (585), Expect = 5e-59, Method: Composition-based stats. Identities = 63/241 (26%), Positives = 107/241 (44%), Gaps = 16/241 (6%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEH--RVEDVATPEGFDRDPELVQAFYNARRR 60 R++VLTGAGIS SGI FR +G++ + E + + F +P F+ Sbjct: 13 ARRIVVLTGAGISTASGIPDFRGPNGIYRQLGAEAERIFDIDHFMVNPSTFYGFHRRFLE 72 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 ++ ++P+ AH +AKL++ ++TQN+D LH+RAG+ NVI +HG + + C Sbjct: 73 MVEA--VRPSFAHRFIAKLEET--KDLAVITQNVDGLHQRAGSRNVIEIHGGIGENSCLT 128 Query: 121 SGQVLDW--TGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGT 178 G+ + E + C ++PHVV+FGE +D + + +G+ Sbjct: 129 CGRTYSLGDLKAMMEEREVPLCSCGGLIKPHVVFFGEGVRDLDRCMELSRDCQVMLVVGS 188 Query: 179 SGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKGLKA 238 S V PAA K ++ G+ P ++ E ++ L A Sbjct: 189 SLTVTPAASLPSLCK---GTLAVVSRGEIYTGH-----VRRPIDIMIEEDIDPFFMRLAA 240 Query: 239 G 239 Sbjct: 241 E 241 >UniRef50_UPI000186F273 NAD-dependent deacetylase HST1, putative n=1 Tax=Pediculus humanus corporis RepID=UPI000186F273 Length = 590 Score = 229 bits (585), Expect = 6e-59, Method: Composition-based stats. Identities = 59/264 (22%), Positives = 97/264 (36%), Gaps = 41/264 (15%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEH--------RVEDVATPEGFDRDPELVQAF 54 ++VLTGAG+S GI FR+ +G++ + + + F++DP F Sbjct: 222 SQNIMVLTGAGVSVSCGIPDFRSRNGIYSRLAVDFPDLPDPQAMFDIQYFNKDPRPFFKF 281 Query: 55 YNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELL 114 R + + +P+ H + L+ G TQNID L + AG VI HG Sbjct: 282 ----ARDIYPGQFKPSPCHRFIRALEQK-GKLLRNYTQNIDTLEQVAGIEKVIQCHGSFA 336 Query: 115 KVRCSQSGQVLDWTGDVTPE-----DKCHCCQ-------------------FPAPLRPHV 150 C++ + + C C+ ++P + Sbjct: 337 TASCTRCKRKVQADDIREDVFAQKIPICVTCEQDNLPGLNTQDKLDYRDLVCRGIMKPDI 396 Query: 151 VWFGE-MPLGMDEIYM-ALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQ 208 +FGE +P E D+ I IG+S V P A + + + +NLEP Sbjct: 397 TFFGEGLPEDFHEAMAGDKDKCDLLIVIGSSLKVRPVA-LIPSSIPASVPQILINLEPLP 455 Query: 209 VGNEFAEKYYGPASQVVPEFVEKL 232 N F + G + +V L Sbjct: 456 HLN-FDVELLGESDVIVDHICRLL 478 >UniRef50_C3WP91 SIR2 family protein n=9 Tax=Fusobacterium RepID=C3WP91_9FUSO Length = 253 Score = 229 bits (585), Expect = 6e-59, Method: Composition-based stats. Identities = 73/240 (30%), Positives = 118/240 (49%), Gaps = 22/240 (9%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWE-----EHRVEDVATPEGFDRDPELVQAFYNA 57 ++ TGAG+S +SG+++FR DGL+ ++R E+V + + F + F Sbjct: 28 SKYLVFFTGAGVSTDSGLKSFRGKDGLYSTLYKGKYRPEEVLSSDFFYSHRNI---FMEY 84 Query: 58 RRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVR 117 +L I+PN HLALA+L+ +G ++TQNID+LH+ AGN NV+ +HG L + Sbjct: 85 VENELNINGIKPNKGHLALAELER-IGLLKAVITQNIDDLHQVAGNKNVLELHGSLKRWY 143 Query: 118 CSQSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMADIFIA 175 C + G+ D C+ +RP V +GE ++E L AD I Sbjct: 144 CLECGKTAD---------NNFSCECGGIVRPDVTLYGENLNQAVVNEAIYQLEQADTLIV 194 Query: 176 IGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKG 235 GTS VYPAA ++ K G + V +N E +Q +E + + + + + + G Sbjct: 195 AGTSLTVYPAAYYLRYFK--GKNLVIINNENTQYDSEASLVLNSNFADTMDKVINIIKMG 252 >UniRef50_B2ARI4 Predicted CDS Pa_4_7390 (Fragment) n=1 Tax=Podospora anserina RepID=B2ARI4_PODAN Length = 344 Score = 228 bits (582), Expect = 1e-58, Method: Composition-based stats. Identities = 90/277 (32%), Positives = 128/277 (46%), Gaps = 47/277 (16%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 ++ R+L + GAG+SA SG+ TFR A GLW H D+ATPE FD DP LV FY RR Sbjct: 58 LKSNRILAVCGAGLSAASGLPTFRGAGGLWRNHNAVDLATPEAFDADPGLVWLFYAYRRH 117 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERA--GNTNVIHMHGELLKVRC 118 +PN AH ALA+L F ++QN+DNLH RA + + +HG L ++C Sbjct: 118 M--ALTAKPNPAHYALAELARKR-PGFKCLSQNVDNLHVRANHPSDQLSLLHGSLFTLKC 174 Query: 119 SQS------------GQVLDWTGDVTPEDK--------------------CHCCQFPAPL 146 + L + P+ HC L Sbjct: 175 TTCSWKDLYNIADPLCPALAPAAESNPDPTKPLPLLDPAQPLAEIKESELPHCPDCKTEL 234 Query: 147 -RPHVVWFGEMPLG--MDEIYMALSM--ADIFIAIGTSGHVYPAAGFVHEAKLHGAH-TV 200 RP VVWFGEM +D+I + D+ + +GTS VYPAAG+ A+ G V Sbjct: 235 QRPGVVWFGEMLDEDMLDDIEEWIEKEPVDMVLVVGTSSAVYPAAGYAERARTKGRTSVV 294 Query: 201 ELNLEPSQVG----NEFAEKYYGPASQVVPEFVEKLL 233 +NLE ++ + + G AS ++PE + ++ Sbjct: 295 TVNLEITEEDWGRMRKGDFGFEGDASLLLPELLRPVI 331 >UniRef50_D0NEH2 NAD-dependent histone deacetylase sir2-like protein n=1 Tax=Phytophthora infestans T30-4 RepID=D0NEH2_PHYIN Length = 570 Score = 228 bits (582), Expect = 1e-58, Method: Composition-based stats. Identities = 58/246 (23%), Positives = 100/246 (40%), Gaps = 18/246 (7%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATP------EGFDRDPELVQAFYN 56 +++VL GAGIS GI FR+ +G++ ++ P E F +P+ AF Sbjct: 206 SKKIVVLAGAGISVSCGIPDFRSENGIYSRLGEYNLPNPQCMFDIEFFRSNPKPFFAFAK 265 Query: 57 ARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELL 114 + P+ +H L L++ G + +QNID L AG + + + HG Sbjct: 266 ELFPKSSGFTFVPSPSHYFLKLLEEK-GKLLRIYSQNIDMLEHAAGISHEHAVLCHGSFA 324 Query: 115 KVRCSQSGQVLDWTGDVTP-----EDKCHCCQFP-APLRPHVVWFGE-MPLGMDEIYMAL 167 C + C C P ++P +V+FGE +P + + Sbjct: 325 TATCVACKRTYPNDAIREDVLNQRVPMCQSCNSPDGIIKPDIVFFGESLPRRFHDSVKSD 384 Query: 168 S-MADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVP 226 AD+ + +G+S V P V K + + +N EP ++F + G + ++V Sbjct: 385 EGEADLVLVMGSSLKVNPVRSIVGRFK-NDTPMILINREPVGRPHKFDVELLGYSDEIVQ 443 Query: 227 EFVEKL 232 E L Sbjct: 444 ELCRLL 449 >UniRef50_B8JAI9 Silent information regulator protein Sir2 n=5 Tax=Myxococcales RepID=B8JAI9_ANAD2 Length = 279 Score = 228 bits (581), Expect = 2e-58, Method: Composition-based stats. Identities = 88/254 (34%), Positives = 119/254 (46%), Gaps = 27/254 (10%) Query: 4 PRVLVLTGAGISAESGIRTFRAADGLW----EEHRVEDVATPEGFDRDPELVQAFYNARR 59 +V+ LTGAGISAESGI TFR A+G W + +++AT E F+ P+ V +Y R Sbjct: 25 GKVVALTGAGISAESGIPTFRGAEGYWVVGSRNYMPQEMATREMFEAAPDEVWRWYLYRF 84 Query: 60 RQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRC- 118 + + +PN H AL +L+ ALG+RF LVTQNID LH RAG+ V +HG+ VRC Sbjct: 85 GVCR--DARPNPGHEALVRLEAALGERFTLVTQNIDGLHRRAGSRRVFCIHGDAAYVRCA 142 Query: 119 SQSG-----------QVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPL----GMDEI 163 ++ G + D + C LRPHV+WF E MD Sbjct: 143 AECGVGLLDLPAMAPRRKDDPFTERERSQLSCPACGGWLRPHVLWFDEYYDEANYRMDSA 202 Query: 164 YMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFA-----EKYY 218 A AD+ + +GTSG A GA V++N E + A Sbjct: 203 VRAAEAADLLLVVGTSGATNLPMQIGRIAFHRGAALVDVNPEENPFAELAARSERGFFAR 262 Query: 219 GPASQVVPEFVEKL 232 G A +P V L Sbjct: 263 GSACARLPGIVAAL 276 >UniRef50_C4XFR7 Putative uncharacterized protein n=1 Tax=Mycoplasma fermentans PG18 RepID=C4XFR7_MYCFE Length = 251 Score = 227 bits (580), Expect = 2e-58, Method: Composition-based stats. Identities = 69/226 (30%), Positives = 107/226 (47%), Gaps = 17/226 (7%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWE----EHRVEDVATPEGFDRDPELVQAFYNA 57 E ++ +GAG+S SGI FR+ADGL+ E + + + ++ + FY Sbjct: 18 ESKHIVFFSGAGVSTASGIPDFRSADGLYSKKFKNMNPESILSRSFWRKN---KKDFYEY 74 Query: 58 RRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVR 117 + I+PN H +A + ++ ++TQNIDNL +AGN VI +HG + + Sbjct: 75 YFSNIAFDNIKPNIIHETVASWCNK--NKCHVITQNIDNLDIKAGNKYVIELHGNINRNY 132 Query: 118 CSQSGQVLDWTGDVTPEDK--CHCCQFPAPLRPHVVWFGEMPLGMD---EIYMALSMADI 172 C G+ D + +DK C+ + P VV + E PL D + A+S +D+ Sbjct: 133 CLLCGKFYDLAQLIHQKDKDGIPTCKCGGVINPDVVLY-EDPLMEDSTNDAAEAISNSDL 191 Query: 173 FIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYY 218 I GTS VYPAA ++H G V LN + S+ N E Sbjct: 192 LIIAGTSLSVYPAASYIHF--YQGKRIVILNKDTSRYENSNNENIL 235 >UniRef50_Q8REC3 NAD-dependent deacetylase n=8 Tax=Fusobacterium RepID=NPD_FUSNN Length = 252 Score = 227 bits (580), Expect = 2e-58, Method: Composition-based stats. Identities = 69/238 (28%), Positives = 115/238 (48%), Gaps = 22/238 (9%) Query: 4 PRVLVLTGAGISAESGIRTFRAADGLWE-----EHRVEDVATPEGFDRDPELVQAFYNAR 58 ++ GAG S +SG++ FR DGL++ ++R E+V + + F ++ F Sbjct: 20 KYLVFFGGAGTSTDSGVKDFRGKDGLYKTLYKDKYRPEEVLSSDFFYSHRDI---FMKYV 76 Query: 59 RRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRC 118 ++L ++PN H+AL +L+ +G ++TQNID+LH+ +GN NV+ +HG L + C Sbjct: 77 EKELNIKGLKPNKGHMALVELE-KIGILKAVITQNIDDLHQVSGNKNVLELHGSLKRWYC 135 Query: 119 SQSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMADIFIAI 176 G+ D C+ +RP V +GE ++E L AD I Sbjct: 136 LSCGKTADRN---------FSCECGGVVRPDVTLYGENLNQSVVNEAIYQLEQADTLIVA 186 Query: 177 GTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLK 234 GTS VYPAA ++ G + + +N +Q E + S V+ V++L K Sbjct: 187 GTSLTVYPAAYYLRYF--RGKNLIIINDMDTQYDGEASLVIKDNFSYVMDRVVKELKK 242 >UniRef50_C6X5T5 NAD-dependent protein deacetylase of SIR2 family n=1 Tax=Flavobacteriaceae bacterium 3519-10 RepID=C6X5T5_FLAB3 Length = 230 Score = 227 bits (579), Expect = 3e-58, Method: Composition-based stats. Identities = 107/233 (45%), Positives = 143/233 (61%), Gaps = 9/233 (3%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 + +++VL+GAG SAESG++TFR +DGLWE HR+EDVA+PEGF R+P+ V FYNARRRQL Sbjct: 4 RKKLVVLSGAGSSAESGVQTFRDSDGLWENHRIEDVASPEGFARNPQFVLDFYNARRRQL 63 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS- 121 +QPN AH LAKLQD L +++TQN+D+LHE+AG+ NVIH+HGEL K R S Sbjct: 64 DL--VQPNDAHRILAKLQDVL--EVVIITQNVDDLHEKAGSQNVIHLHGELRKARPVDSL 119 Query: 122 GQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGH 181 + W D+ D + LRPH+VWFGEM M+ AD F+ +GTS Sbjct: 120 TDIRIWNKDLNIGDLA---EDGTQLRPHIVWFGEMVPEMERAVETAQTADYFLIVGTSMQ 176 Query: 182 VYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLK 234 VYPAAG V ++ P + A + A++ + F EKLL+ Sbjct: 177 VYPAAGLVSYVPES-CEIFGIDPNPDSQFSAGATFFNTTATEGMRLFKEKLLE 228 >UniRef50_Q0CI01 Putative uncharacterized protein n=2 Tax=Leotiomyceta RepID=Q0CI01_ASPTN Length = 320 Score = 227 bits (579), Expect = 3e-58, Method: Composition-based stats. Identities = 92/302 (30%), Positives = 134/302 (44%), Gaps = 71/302 (23%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 RV+ L GAGISA SG+ TFR A GLW + D+ATPE F+ +P+LV FY+ RR Sbjct: 21 SRRVIALLGAGISASSGLPTFRGAGGLWRTYEATDLATPEAFEANPDLVWQFYSYRRHM- 79 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERA--GNTNVIHMHGELLKVRCSQ 120 + QPN AH ALA+L F+ +TQN+D L +RA + + +HG L V+C+ Sbjct: 80 -ALKAQPNRAHHALAELARR-NKDFITLTQNVDGLSQRAQHPSEQIHLLHGSLFTVKCTS 137 Query: 121 --S-------------------------------------------------GQVLDWTG 129 G+ +D + Sbjct: 138 FYCNYSRHDDFTDPIVPALAIPRNLPEPKPSADDNTGEEASRSLYNALGIAEGEEIDISD 197 Query: 130 DVTPEDK------CHCCQFP-APLRPHVVWFGEMPL--GMDEIYMALSM--ADIFIAIGT 178 D P C + LRP VVWFGE +D + L D+ + IGT Sbjct: 198 DRVPLPGLSTDVLPKCPECKEGLLRPGVVWFGESLPTHTLDTVDSWLRSGPVDLILVIGT 257 Query: 179 SGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNE----FAEKYYGPASQVVPEFVEKLLK 234 S VYPAAG+V +A+ GA +N++ + VG+ + G A +VPE ++ ++ Sbjct: 258 SSRVYPAAGYVDKARARGARVAVVNMDRNDVGSSGLKAGDWFFKGDAGIIVPEILKGVIG 317 Query: 235 GL 236 + Sbjct: 318 EI 319 >UniRef50_C4R311 NAD(+)-dependent histone deacetylase n=3 Tax=Saccharomycetales RepID=C4R311_PICPG Length = 325 Score = 226 bits (578), Expect = 4e-58, Method: Composition-based stats. Identities = 82/302 (27%), Positives = 132/302 (43%), Gaps = 69/302 (22%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 + +L L GAG+SA SG+ TFR + GLW+ + D+ATP+ F+ DP LV FY+ RR Sbjct: 17 KCRTILALCGAGLSASSGLPTFRGSGGLWKNYSSMDLATPDAFNVDPGLVWQFYSYRR-- 74 Query: 62 LQQPEIQPNAAHLALAKLQD---ALGDRFLLVTQNIDNLHERAGN--TNVIHMHGELLKV 116 + + +PN H AL++L + G +FL +TQN+D L RA + ++ +HG L + Sbjct: 75 YKAIQAKPNNGHYALSQLSKVAASKGKKFLTLTQNVDGLSRRAHHDPEQLLELHGSLFTL 134 Query: 117 RCS--QS-----------------GQVLDWTGDVTPEDK--------------------- 136 +C+ G +W + + Sbjct: 135 KCTSFDCTYTENNNFKHPLTPQLQGCEEEWINPRKRQRRTENENENENENEDGKDAVIST 194 Query: 137 -----------------CHCCQFP-APLRPHVVWFGEM----PLGMDEIYMALSMADIFI 174 C Q LRP VVWFGE L + ++ D+ + Sbjct: 195 TGSPEFTPVKEIPRSGLPTCPQCKTGLLRPGVVWFGESLPFKVLDQADQFIMSQKVDLIL 254 Query: 175 AIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLK 234 IGTS V+PAAG+V+ KL G N + + K+ G A++++P+ ++ L+ Sbjct: 255 VIGTSQSVWPAAGYVNRVKLQGGKVAIFNTDEEDLEGCDGWKFLGDAAELLPQALKPLIG 314 Query: 235 GL 236 + Sbjct: 315 DI 316 >UniRef50_Q21921 NAD-dependent deacetylase SIR2 homolog n=2 Tax=Caenorhabditis RepID=SIRT1_CAEEL Length = 607 Score = 226 bits (578), Expect = 4e-58, Method: Composition-based stats. Identities = 64/240 (26%), Positives = 102/240 (42%), Gaps = 20/240 (8%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVE--DVATPEG------FDRDPELVQAF 54 K +LVLTGAG+S GI FR+ DG++ R E D+ P F +P F Sbjct: 145 KKHILVLTGAGVSVSCGIPDFRSKDGIYARLRSEFPDLPDPTAMFDIRYFRENPA---PF 201 Query: 55 YNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELL 114 YN R ++ + P+ +H + +L+ + G TQNID L + G V+ HG Sbjct: 202 YNFAR-EIFPGQFVPSVSHRFIKELETS-GRLLRNYTQNIDTLEHQTGIKRVVECHGSFS 259 Query: 115 KVRCSQSGQVLDWT---GDVTPEDKCHCCQFPAPLRPHVVWFGEMP--LGMDEIYMALSM 169 K C++ GQ D +V HC + ++P++V+FGE + Sbjct: 260 KCTCTRCGQKYDGNEIREEVLAMRVAHCKRCEGVIKPNIVFFGEDLGREFHQHVTEDKHK 319 Query: 170 ADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFV 229 D+ + IG+S V P A H + + +N E N + G ++ + Sbjct: 320 VDLIVVIGSSLKVRPVALIPHCVDKN-VPQILINRESLPHYN-ADIELLGNCDDIIRDIC 377 >UniRef50_UPI000051AA14 PREDICTED: similar to NAD-dependent deacetylase sirtuin-1 (hSIRT1) (hSIR2) (SIR2-like protein 1) n=1 Tax=Apis mellifera RepID=UPI000051AA14 Length = 868 Score = 226 bits (577), Expect = 4e-58, Method: Composition-based stats. Identities = 61/241 (25%), Positives = 99/241 (41%), Gaps = 22/241 (9%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEH--RVEDVATPEG------FDRDPELVQAF 54 R++VLTGAG+S GI FR+ DG++ D+ P+ F +DP F Sbjct: 203 SNRIIVLTGAGVSVSCGIPDFRSRDGIYSRLAQDFPDLPDPQAMFDINYFSQDPRPFYKF 262 Query: 55 YNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELL 114 R++ + +P+ H + L D +QNID L + AG NVI HG Sbjct: 263 ----AREIYPGQFKPSPCHRFIKML-DKQKKLLRNYSQNIDTLEQVAGIENVIECHGSFA 317 Query: 115 KVRCSQSGQVL---DWTGDVTPEDKCHCCQFPAPLRPHVVWFGE-MPLGM-DEIYMALSM 169 C++ + D D+ + C + ++P +V+FGE +P D + Sbjct: 318 TASCTRCKYQVKADDIREDIFSQRIPLCPKC--IMKPDIVFFGEGLPDAFHDAMAKDKDE 375 Query: 170 ADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFV 229 D+ I IG+S V P A H + +N E +F + G ++ + Sbjct: 376 CDLLIVIGSSLKVRPVALIPSSIPSH-VPQILINRESLPH-LKFDVELLGDGDIIINQLC 433 Query: 230 E 230 Sbjct: 434 H 434 >UniRef50_A9SDL4 SIR2 family protein n=2 Tax=Physcomitrella patens subsp. patens RepID=A9SDL4_PHYPA Length = 323 Score = 226 bits (577), Expect = 5e-58, Method: Composition-based stats. Identities = 87/250 (34%), Positives = 120/250 (48%), Gaps = 27/250 (10%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 +V+VLTGAGISAESGI TFR GLW + ++ATP F +P LV FY+ RR + Sbjct: 47 AKKVVVLTGAGISAESGIPTFRGEGGLWRDFDATELATPGAFAANPSLVWEFYHYRRTIV 106 Query: 63 QQPEIQPNAAHLALAKLQ---DALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCS 119 PNA H A+A LQ LG F+L+TQNID LH +AG+T+V+ +HG L + RC Sbjct: 107 --AGASPNAGHYAVAALQRRCRRLGKDFILLTQNIDGLHAKAGSTDVVELHGSLWETRCC 164 Query: 120 QSGQV-----------LDWTGDVTPEDK--------CHCCQFPAPLRPHVVWFGEMPLG- 159 V LD G + C + LRP V+WFGE Sbjct: 165 HCKAVEANRNMPICPALDGKGAPDTVHEANIPSMQLPRCNKCNGLLRPRVIWFGECLERD 224 Query: 160 -MDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYY 218 + AL D+ + +GTS VY + E +LH VE L+ ++ + Sbjct: 225 VLRRTDDALQGCDLLLVVGTSAVVYLFWRNMMEVELHTDF-VESLLQDDRLRSRIGLALR 283 Query: 219 GPASQVVPEF 228 + ++ F Sbjct: 284 EKSQYLLVAF 293 >UniRef50_B2VWU1 NAD-dependent deacetylase sirtuin-5 n=3 Tax=Leotiomyceta RepID=B2VWU1_PYRTR Length = 320 Score = 226 bits (576), Expect = 7e-58, Method: Composition-based stats. Identities = 90/288 (31%), Positives = 136/288 (47%), Gaps = 57/288 (19%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 + R+L L GAG+SA SG+ TFR A G+W H +ATP+ F+RDP LV FY+ RR Sbjct: 25 KSTRILALLGAGLSASSGLPTFRGAGGMWRTHDATSLATPQAFERDPGLVWQFYSYRRHM 84 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGN--TNVIHMHGELLKVRCS 119 + +PN AH ALA+L + F+ ++QN+D L RA + + +HG L V+CS Sbjct: 85 --ALKAKPNPAHYALAELARKR-EEFITLSQNVDGLSPRAQHPIDKLKLLHGSLFDVKCS 141 Query: 120 Q--SGQV--------------------------------LDWTG--------DVTPEDKC 137 V LD + D + C Sbjct: 142 DFFCKYVERNNYTDPIVPALAIPSDDSDPTTTSALAARELDISDINVAIPELDYSHLPHC 201 Query: 138 HCCQFPAPLRPHVVWFGE-MPLGMDE----IYMALSMADIFIAIGTSGHVYPAAGFVHEA 192 C+ LRP VVWFGE +P + + D+ + IGTS VYPAAG+V EA Sbjct: 202 PACK-TGLLRPGVVWFGEALPKDVMKDVDDFIDDDRNVDLIMVIGTSAKVYPAAGYVDEA 260 Query: 193 KLHGAHTVELNLEPSQVGN----EFAEKYYGPASQVVPEFVEKLLKGL 236 ++ GA +N++P + + + G A+++VPE ++ ++ + Sbjct: 261 RMKGARVAVINMDPEDIPAGGLYDKDWFFQGDAARIVPELLKSVIGEI 308 >UniRef50_A1DG07 SIR2 family histone deacetylase, putative n=8 Tax=Eurotiomycetidae RepID=A1DG07_NEOFI Length = 425 Score = 225 bits (575), Expect = 8e-58, Method: Composition-based stats. Identities = 65/244 (26%), Positives = 93/244 (38%), Gaps = 21/244 (8%) Query: 4 PRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPE------GFDRDPELVQAFYN 56 R++V+ GAGIS +GI FR+ D GL+ D+ PE F +P + FY Sbjct: 36 RRIVVMVGAGISTSAGIPDFRSPDTGLYSNLAFLDLPEPEDVFDISYFRENP---RPFYA 92 Query: 57 ARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGN--TNVIHMHGELL 114 R +L +P AH + L D G TQNID L AG ++ HG Sbjct: 93 LAR-ELAPGRYRPTIAHSFVKLLHDK-GLLLKHFTQNIDCLERLAGVPGEKIVEAHGSFA 150 Query: 115 KVRCSQSGQVLD---WTGDVTPEDKCHCCQFPAPLRPHVVWFGE-MPLGMDEIYMALSMA 170 C + + HC ++P +V+FGE +P A Sbjct: 151 SQHCIDCKAAYPEPQMKEAIAKGEVPHCPHCNGFVKPDIVFFGEALPEEFHANRSLPEQA 210 Query: 171 DIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPS--QVGNEFAEKYYGPASQVVPEF 228 D+ I +GTS V+P A + G V +N+E G V +F Sbjct: 211 DLCIVMGTSLTVHPFASLPSFCRE-GVPRVLINMERVGGMGSRPDDVLLLGDCDAGVRKF 269 Query: 229 VEKL 232 L Sbjct: 270 ARAL 273 >UniRef50_Q8CNF4 NAD-dependent deacetylase n=64 Tax=Staphylococcus RepID=NPD_STAES Length = 246 Score = 225 bits (575), Expect = 8e-58, Method: Composition-based stats. Identities = 68/234 (29%), Positives = 114/234 (48%), Gaps = 14/234 (5%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHR-----VEDVATPEGFDRDPELVQAFYNA 57 +++ TGAG+S SGI FR+ GL++E E + + + + E FY+ Sbjct: 16 SNQIVFFTGAGVSVASGIPDFRSMGGLYDEISKDGQSPEYLLSIDHLHDNKESFINFYHE 75 Query: 58 RRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVR 117 R L + +PN H +A+L++ ++TQNID LHE AG+ N+ +HG L + Sbjct: 76 R---LLIADKKPNIVHQWIAQLENQ-QKSLGVITQNIDGLHEDAGSHNIDELHGTLNRFY 131 Query: 118 CSQSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMP--LGMDEIYMALSMADIFIA 175 C + + +T K +C + +RP +V +GEM + + + AD I Sbjct: 132 CINCYEEYSKSYVMTHHLK-YCEKCGNVIRPDIVLYGEMLNQKTVFKALDKIQHADTLIV 190 Query: 176 IGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFV 229 +G+S V PAAGFV E K G + V +N + + + + + + V+ E V Sbjct: 191 LGSSLVVQPAAGFVSEFK--GDNLVIINRDATPYDHTASLVIHDDMTSVIEEIV 242 >UniRef50_A3ZMQ7 Sir2 family, possible ADP ribosyltransferase n=1 Tax=Blastopirellula marina DSM 3645 RepID=A3ZMQ7_9PLAN Length = 252 Score = 225 bits (574), Expect = 1e-57, Method: Composition-based stats. Identities = 66/242 (27%), Positives = 103/242 (42%), Gaps = 14/242 (5%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR- 60 E ++ TGAGIS ESGI FR+ G+W ++R + F + E + ++ + Sbjct: 16 ESESTVLFTGAGISTESGIPDFRSPGGVWTKYRT---IYFDEFRQSAEARREYWRQKSEA 72 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 ++ PNA H LA + A G L+TQNID LH+ AG+ V+ +HG + C Sbjct: 73 HVEFSAAAPNAGHQILAAWE-AHGVARGLITQNIDGLHQIAGSRQVLELHGTAREATCLD 131 Query: 121 SGQVLDWT------GDVTPEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMADI 172 + + C C+ L+ V FG+M ++ Y S AD+ Sbjct: 132 CAARFEIDPLVVQFRETGEVPPCPNCE-TGRLKHATVSFGQMLPTDVLETAYDWCSDADL 190 Query: 173 FIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 +AIG+S V PAA + G V LN + + + K G + L Sbjct: 191 ILAIGSSLVVTPAADLPVAVRRRGGRVVILNRDETGLDQIADAKLSGGIGATLVAIDAAL 250 Query: 233 LK 234 + Sbjct: 251 SR 252 >UniRef50_D2Q7L2 SIR2 family protein n=13 Tax=Bifidobacterium RepID=D2Q7L2_9BIFI Length = 254 Score = 225 bits (574), Expect = 1e-57, Method: Composition-based stats. Identities = 71/248 (28%), Positives = 110/248 (44%), Gaps = 19/248 (7%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEH-RVEDVATPEGFDRDPELVQAFYNARRRQ 61 ++ VLTGAGIS +GI FR DG+W +H +V + F + E + + ++ Sbjct: 2 SKKIAVLTGAGISTSAGIPDFRGPDGVWTKHPEQMNVYDIDAFLANEEDREYSWRWQKES 61 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTN--VIHMHGELLKVRCS 119 QP AH AL KL+ A G LL TQN D LHE+AGN++ ++++HG + C Sbjct: 62 PVW-NAQPGEAHKALVKLEQA-GMLTLLATQNFDALHEKAGNSDNVIVNLHGTIGTSHCM 119 Query: 120 QSGQVLDWTG-----DVTPEDKCH-------CCQFPAPLRPHVVWFGEMPLG--MDEIYM 165 + D D P+ CH ++ VV+FGE M++ Y Sbjct: 120 KCHAKYDTADIMANLDNEPDPHCHRKLPYSGNMPCNGLIKTDVVYFGEALPDGAMEKSYR 179 Query: 166 ALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVV 225 + AD IG++ V PAA V A G +N+ +Q + + Sbjct: 180 LATQADELWVIGSTLEVMPAASIVPVAAQAGVPITIMNMGHTQYDRLADRLIRDDIAVAL 239 Query: 226 PEFVEKLL 233 P V++ + Sbjct: 240 PRLVDETI 247 >UniRef50_A5USR3 Silent information regulator protein Sir2 n=3 Tax=Chloroflexi (class) RepID=A5USR3_ROSS1 Length = 259 Score = 225 bits (574), Expect = 1e-57, Method: Composition-based stats. Identities = 81/240 (33%), Positives = 120/240 (50%), Gaps = 7/240 (2%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAA-DGLWEEHRVEDVATPEGFDRDPELVQAFYNARR 59 + RV+ LTG G++AESGI +FR A G W ++ V ++ATP+ F R+P LV +Y RR Sbjct: 14 INARRVVALTGGGVAAESGIPSFREAHTGHWAQYDVSELATPQAFVRNPRLVWEWYAYRR 73 Query: 60 RQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCS 119 + QP H AL L+ F L+TQ+ID LH RAG+ ++I ++G L + RC Sbjct: 74 --MLAERAQPGVTHYALVDLEQHYPA-FTLITQSIDGLHWRAGSRDLIELNGSLRRCRCF 130 Query: 120 QSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMD--EIYMALSMADIFIAIG 177 +SG + + D E C Q + LRP VV FGE + A+ D+F+ +G Sbjct: 131 ESGHIA-FAWDDDGEIPPRCVQCGSLLRPDVVMFGEGLPHHELRRARQAVEQCDVFLCVG 189 Query: 178 TSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKGLK 237 T G + P A F A+ HGA + + E S + E V ++ + Sbjct: 190 TVGAIEPVASFPFVARRHGAFVMTIAPEDSIYTLMADYVIAAQPGVIASELVRLIVGDVG 249 >UniRef50_UPI0001744E27 NAD-dependent protein deacetylases, SIR2 family n=1 Tax=Verrucomicrobium spinosum DSM 4136 RepID=UPI0001744E27 Length = 232 Score = 225 bits (574), Expect = 1e-57, Method: Composition-based stats. Identities = 90/230 (39%), Positives = 137/230 (59%), Gaps = 7/230 (3%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 +V+V++GAG+SA SG+ TFR +G W+++R EDVA+P ++R PE+V FYN RR Sbjct: 6 FNSKKVVVISGAGLSAPSGLSTFRDNNGYWKQYRFEDVASPRAWERQPEVVLEFYNERRT 65 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 + ++PNA H A+A+L+D ++VTQN+D+LHERAG+T VIH+HGEL K R S Sbjct: 66 K--AASVEPNAGHRAIAELEDRF--EVVVVTQNVDDLHERAGSTRVIHLHGELNKAR-ST 120 Query: 121 SGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSG 180 S + L + P C+ + LRPH+VWFGE +D ++ A + +GTS Sbjct: 121 SDESLVYELGARPIALGDLCEKGSQLRPHIVWFGEEVKAIDLAADEVASAGRVLVVGTSL 180 Query: 181 HVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVE 230 VYPAAG A + A ++L+ + +F G A ++P+ ++ Sbjct: 181 KVYPAAGLCSCAHEY-ATKFYVDLDAKRQVPDFT-VIQGSAEVILPDLLK 228 >UniRef50_C6Y0J4 Silent information regulator protein Sir2 n=1 Tax=Pedobacter heparinus DSM 2366 RepID=C6Y0J4_PEDHD Length = 227 Score = 225 bits (574), Expect = 1e-57, Method: Composition-based stats. Identities = 100/230 (43%), Positives = 134/230 (58%), Gaps = 7/230 (3%) Query: 4 PRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQ 63 RV++LT AGISAESG++TFR ADGLWE + + DVATPE + R+PELVQ FYN RR+ + Sbjct: 2 KRVVILTDAGISAESGLKTFRDADGLWEGYNIADVATPEAWKRNPELVQRFYNERRKSVI 61 Query: 64 QPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQ 123 E QPNAAH AL LQ ++TQNID+LHERAG NV+H+HG + + + S Sbjct: 62 --EAQPNAAHKALTLLQTKY--NVHIITQNIDDLHERAGAENVLHLHGIITRSQ-SDVDS 116 Query: 124 VLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGHVY 183 + + + C++ PLRPHVVWFGE + + ADIF IGTS VY Sbjct: 117 AVTYPIEGWEIGPSAVCEYGMPLRPHVVWFGENVPNLMPAAKICAKADIFAVIGTSLVVY 176 Query: 184 PAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLL 233 PAAG ++ Q+ F ++ A+ VPE V++L+ Sbjct: 177 PAAGLTDYVPDTALKYA-VDPNIPQIKGNF-KRIEKAATIGVPEMVKELM 224 >UniRef50_C1VAT1 NAD-dependent protein deacetylase, SIR2 family n=1 Tax=Halogeometricum borinquense DSM 11551 RepID=C1VAT1_9EURY Length = 270 Score = 225 bits (573), Expect = 1e-57, Method: Composition-based stats. Identities = 72/243 (29%), Positives = 104/243 (42%), Gaps = 10/243 (4%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQP 65 V VLTGAG+S SG+ TFR +G+W + F+RDP ++ Sbjct: 18 VTVLTGAGVSNASGVPTFRGEEGIWNNEFDPADFRMDRFERDPAGFWTDRLELHERMFGD 77 Query: 66 EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQ-- 123 PN AH ALA+L+D LG ++VTQN D LH AG +I +HG + C + G+ Sbjct: 78 VTGPNDAHRALARLED-LGVVDVVVTQNTDGLHAEAGTNRLIELHGNNARSVCVECGESV 136 Query: 124 ----VLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPL--GMDEIYMALSMADIFIAIG 177 LD C L+P VV FGE D +D+FI +G Sbjct: 137 PTETALDDVRAGNSPPSCPVVGCTGHLKPDVVLFGERLPGGAYDSARRMAWESDVFIVVG 196 Query: 178 TSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKGLK 237 +S V PA+ EA G + ++ + G A++ +P VE + L Sbjct: 197 SSLTVVPASTLPEEAAERG-QLAIFDTGETEKDHLAHYLVRGDATETLPALVEAVQARLG 255 Query: 238 AGS 240 + Sbjct: 256 REA 258 >UniRef50_Q5KZE8 NAD-dependent deacetylase 2 n=8 Tax=Bacteria RepID=NPD2_GEOKA Length = 247 Score = 225 bits (573), Expect = 1e-57, Method: Composition-based stats. Identities = 68/234 (29%), Positives = 106/234 (45%), Gaps = 5/234 (2%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHR-VEDVATPEGFDRDPELVQAFYNARRR 60 E + VLTGAG+S ESGI FR+ +GL+ + VE + + +DP + Sbjct: 13 EANTIAVLTGAGMSTESGIPDFRSENGLYAQEDNVEYYLSEYYYKKDPVDFWRRFKRMFS 72 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 PN H L L++ +G ++TQNID LH +AG+TNVI +HG L C Sbjct: 73 LKMMGGFAPNDGHRFLRWLEE-MGKTVTILTQNIDGLHTKAGSTNVIELHGTLQTATCPS 131 Query: 121 SGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSG 180 G D + E C + ++P VV FG + M+E + A + +D+ +A+GTS Sbjct: 132 CGNKYDLSFINRHE-VPRCEKCQTIVKPDVVLFGGLVPRMEEAFAAAAASDLLLAMGTSL 190 Query: 181 HVYPAAGFVHEAKLHG--AHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 V P V +N +++ F YG + V +++ Sbjct: 191 EVAPVNQIPFYVAAESPATRKVLINKTATRMDGMFDLVIYGGIGKTVASVRKQI 244 >UniRef50_Q6C8C7 YALI0D20724p n=1 Tax=Yarrowia lipolytica RepID=Q6C8C7_YARLI Length = 303 Score = 225 bits (573), Expect = 2e-57, Method: Composition-based stats. Identities = 83/284 (29%), Positives = 120/284 (42%), Gaps = 54/284 (19%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 + ++L L GAG+S SG+ TFR G+W + ++ATPE F DP V FY RR Sbjct: 14 LSSRKILALVGAGLSQSSGLPTFRGEGGIWRNYDAAELATPEAFHNDPSTVWQFYAHRRH 73 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTN--VIHMHGELLKVRC 118 + +PN H ALA+L L RFL +TQN+D L RA + ++ +HG+L ++C Sbjct: 74 M--SLKAKPNPGHYALAELARRLRGRFLTLTQNVDGLSSRAEHPQEALLKLHGDLFALKC 131 Query: 119 SQ--SGQVLDWTGDVTP----------------------EDKCHCCQFP-APLRPHVVWF 153 + + ED C LRP VVWF Sbjct: 132 TSFFCSYTTEDNFADPLTPALSITDNYNSAQLQRHRIPVEDLPTCPHCKEGLLRPGVVWF 191 Query: 154 GEMPLGM-----DEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEP-- 206 GE DE D+ I +GTSG V+PAAG+V L G N+E Sbjct: 192 GESLPFKVMNTADEFLED-EDVDLIIVVGTSGSVWPAAGYVERVALSGGKVAIFNMEIDH 250 Query: 207 ----------SQVGNEFAEK-------YYGPASQVVPEFVEKLL 233 + + E + G AS+ +P+ +E ++ Sbjct: 251 YQYGESEAETTDSEDSSNEDAVIEGWAFKGNASEWLPKALEPVI 294 >UniRef50_C5CY53 Silent information regulator protein Sir2 n=1 Tax=Variovorax paradoxus S110 RepID=C5CY53_VARPS Length = 249 Score = 224 bits (572), Expect = 2e-57, Method: Composition-based stats. Identities = 81/233 (34%), Positives = 110/233 (47%), Gaps = 12/233 (5%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 R+ VL+GAG+S SGI T+R ADGLW + E RDP F+ RR Sbjct: 24 ARRIAVLSGAGLSKASGISTYRDADGLWMNQNALQFSHAEDLQRDPRRFTRFW--ARRLS 81 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG 122 QPN H ALA LQ L LVTQN+D L AG +V+ +HG L + RC G Sbjct: 82 TVEAAQPNPGHAALALLQR-LRPATRLVTQNVDGLLSIAGGLDVLELHGSLRRWRCDHCG 140 Query: 123 QVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEM--PLGMDEIYMALSMADIFIAIGTSG 180 P C + + RP VV FGEM P + + +A +D+F+ +G++ Sbjct: 141 NR------RGPWPFHRCMRCASRARPDVVMFGEMLNPGVLHDAQVAAQESDVFMVVGSTA 194 Query: 181 HVYPAAGFVHEAKLHGAHTVELNLEPSQ-VGNEFAEKYYGPASQVVPEFVEKL 232 VYPAA A GA + LN+EP + A G A ++P + + Sbjct: 195 VVYPAAELPQLAMSRGARLITLNMEPLPQLDAAAAVVLRGAAEVLLPRLLAGI 247 >UniRef50_C8W9D8 Silent information regulator protein Sir2 n=2 Tax=Atopobium RepID=C8W9D8_ATOPD Length = 283 Score = 224 bits (572), Expect = 2e-57, Method: Composition-based stats. Identities = 72/277 (25%), Positives = 106/277 (38%), Gaps = 57/277 (20%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEE------------------------------ 32 ++ GAG+S ESGI FR +GL+ + Sbjct: 14 SDNIVFFGGAGVSTESGIPDFRGTNGLYRQGGIKIENMTIGLGQDGYDMGKETCDLGNGI 73 Query: 33 -----------------HRVEDVATPEGFDRDPELVQAFYNARRRQLQQPEIQPNAAHLA 75 +E++ + + F P A+Y R E QPN AH Sbjct: 74 TVDPDNEESFAYSKAPDFTLEEIFSLDVFLDYPA---AYYTYFRNSHHLGEAQPNIAHKW 130 Query: 76 LAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVLDWTGDVTPED 135 LA L+ A G +VTQNID LH+ AG+ V +HG + C + G V Sbjct: 131 LAALE-AEGKLRAVVTQNIDGLHQAAGSKRVFELHGNETRFYCPECGHVYTLDQIEEQSS 189 Query: 136 KCHCCQFPAPLRPHVVWFGEMPLGMDEIY---MALSMADIFIAIGTSGHVYPAAGFVHEA 192 CQ A +RP +V++GE L MD +Y A+S A++ I G+S V PA G + Sbjct: 190 VVPLCQCGAVIRPDIVFYGEG-LNMDTVYGALNAISQAEVLIVAGSSLVVQPAVGLLDY- 247 Query: 193 KLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFV 229 G V +N +P+ V+ + Sbjct: 248 -YEGNKMVIINDQPTPYDGRANLVIRDRIGAVIEHLL 283 >UniRef50_C4Q5J6 Chromatin regulatory protein sir2, putative n=2 Tax=Schistosoma RepID=C4Q5J6_SCHMA Length = 618 Score = 224 bits (571), Expect = 2e-57, Method: Composition-based stats. Identities = 62/241 (25%), Positives = 101/241 (41%), Gaps = 21/241 (8%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEH--RVEDVATPEG------FDRDPELVQAFYNA 57 +LV+TGAGIS GI FR+ DG++ D+++P+ F R+P F Sbjct: 157 ILVITGAGISVSCGIPDFRSRDGIYARLSRDYPDLSSPQAMFDMSYFKRNPIPFFKF--- 213 Query: 58 RRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVR 117 ++L + P+ H +A L+ TQNID L + AG T +I HG Sbjct: 214 -AKELFPGQFSPSITHRMIALLESKD-KLLRNYTQNIDTLEQAAGITRLIQCHGSFASAT 271 Query: 118 CSQSGQVL--DWTGDVTPEDKCHCC--QFPAPLRPHVVWFGE--MPLGMDEIYMALSMAD 171 C+ + D+ + C L+P +V+FGE D + + D Sbjct: 272 CTNCKLKVSSDFIKEAIFTQSIPRCTNSSYGVLKPDIVFFGEGLSNEFHDSLSNDIKQTD 331 Query: 172 IFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEK 231 + + IG+S V P + + A + +N EP ++F + G +V E + Sbjct: 332 LVLVIGSSLKVRPVSHIPN-AVPRQVPQILINREPLS-NHDFDVELLGDCDVIVSELCHR 389 Query: 232 L 232 L Sbjct: 390 L 390 >UniRef50_B9E751 Putative uncharacterized protein n=1 Tax=Macrococcus caseolyticus JCSC5402 RepID=B9E751_MACCJ Length = 243 Score = 224 bits (571), Expect = 2e-57, Method: Composition-based stats. Identities = 68/232 (29%), Positives = 111/232 (47%), Gaps = 14/232 (6%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEE-----HRVEDVATPEGFDRDPELVQAFYN 56 + +++ GAG+S ESGI FR+ADG++ + H E++ + + F++ P+ F+ Sbjct: 13 KSEKIVFFGGAGVSTESGIPDFRSADGIFMQETSIEHSPEEIISIDFFNKYPKQYFKFH- 71 Query: 57 ARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKV 116 +L P +PN AH + KL+ G +VTQNID LH+ AGN+ V+ +HG + Sbjct: 72 --FDKLVYPHAKPNIAHRFITKLEQQ-GKDVTVVTQNIDGLHQSAGNSKVLELHGNVQTN 128 Query: 117 RCSQSGQVLDWTGDVTPEDKCHCCQFPA-PLRPHVVWFGEMPLG--MDEIYMALSMADIF 173 C+ +V +D C +RP +V +GE + E A+ AD+ Sbjct: 129 YCTHCKKVYQLEDISMDKDGIPRCLHDGHIIRPDIVMYGEALNSSVITEAITAIQNADMM 188 Query: 174 IAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVV 225 I GTS VYPA+ FV +G +N + A + +V+ Sbjct: 189 IIAGTSLVVYPASTFVDFF--NGETLAVINKTSLRTVRSDALIFEDYIGEVL 238 >UniRef50_A2QFF9 Complex: Sir2p is one of four Silent Information Regulator genes in yeast. Sir2p n=19 Tax=Dikarya RepID=A2QFF9_ASPNC Length = 378 Score = 224 bits (571), Expect = 3e-57, Method: Composition-based stats. Identities = 64/243 (26%), Positives = 96/243 (39%), Gaps = 21/243 (8%) Query: 4 PRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEG------FDRDPELVQAFYN 56 RV+V+ GAGIS +GI FR+ D G++ D+ PE F ++P + FY Sbjct: 36 KRVVVMVGAGISTSAGIPDFRSPDTGIYSNLAHLDLPDPEAVFDISFFRQNP---RPFYA 92 Query: 57 ARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGN--TNVIHMHGELL 114 R +L + +P AH + L D G +QNID L AG ++ HG Sbjct: 93 LAR-ELAPGQFRPTIAHSFIKLLYDK-GMLLKHFSQNIDCLERLAGVPGDKIVEAHGSFA 150 Query: 115 KVRCSQSGQVLD---WTGDVTPEDKCHCCQFPAPLRPHVVWFGE-MPLGMDEIYMALSMA 170 C +T +C Q ++P +V+FGE +P + A Sbjct: 151 TQHCIDCKAEYPEDLMKKAITKGKVPYCTQCKGLVKPDIVFFGESLPADFFDNRDLPEQA 210 Query: 171 DIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPS-QVGNEFAEKY-YGPASQVVPEF 228 D+ I +GTS V P A G V +N+E +G+ + G V Sbjct: 211 DLCIVMGTSLQVQPFASLPAFVSD-GVPRVLINMERVGGLGSRPDDVLVLGDCDTGVRRL 269 Query: 229 VEK 231 Sbjct: 270 ARA 272 >UniRef50_UPI0001925E2D PREDICTED: similar to NAD-dependent deacetylase sirtuin-1 n=1 Tax=Hydra magnipapillata RepID=UPI0001925E2D Length = 424 Score = 223 bits (568), Expect = 5e-57, Method: Composition-based stats. Identities = 65/252 (25%), Positives = 101/252 (40%), Gaps = 25/252 (9%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEH--------RVEDVATPEGFDRDPELVQA 53 E ++VLTGAG+S GI FR+ DG++ + + F +P Sbjct: 96 ESKNIIVLTGAGVSVSCGIPDFRSRDGIYARLHKDYPDLPDPQAMFDIHYFRNNP---WP 152 Query: 54 FYNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGEL 113 F+ +++ + P+ H ++KL D G TQNID L + AG NV+ HG Sbjct: 153 FFKFA-KEIYPGQFTPSLCHRFISKL-DQQGKLLRNYTQNIDTLEQVAGIKNVLQCHGSC 210 Query: 114 LKVRCSQSGQVLDWT---GDVTPEDKCHCCQFPAP-----LRPHVVWFGEMPLG--MDEI 163 C + D+ + +C Q P L+P +V+FGE +I Sbjct: 211 ATATCMNCKYKVSAEFIKEDIFQQKIPYCNQCSDPNSLNILKPDIVFFGESLSDDFYSQI 270 Query: 164 YMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQ 223 AD+ I IG+S V P A K + + +N E EF + YG Sbjct: 271 NKDKDEADLLIVIGSSLKVRPVALIPSLIKQN-VPQLLINREQLHHI-EFDVEMYGNCDD 328 Query: 224 VVPEFVEKLLKG 235 V+ +L + Sbjct: 329 VICYLCSELGRE 340 >UniRef50_C5M5U2 NAD-dependent histone deacetylase SIR2 n=2 Tax=Candida RepID=C5M5U2_CANTT Length = 499 Score = 222 bits (566), Expect = 1e-56, Method: Composition-based stats. Identities = 69/253 (27%), Positives = 102/253 (40%), Gaps = 28/253 (11%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEH------RVEDVATPEGFDRDPELVQAFYN 56 +++V+TGAGIS GI FR+ GL+ + + V E F +DP L FY Sbjct: 220 AKKIVVITGAGISTSLGIPDFRSFQGLYTQLSKLQLSDPQKVFDMETFKKDPSL---FYT 276 Query: 57 ARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELL 114 L PE + H L L+D TQNIDNL +RAG +I HG Sbjct: 277 IAHMVL-PPEGKFALFHSFLKLLEDK-NKLLRNYTQNIDNLEQRAGISPEKLIQCHGSFS 334 Query: 115 KVRCSQSGQVLDWTGDVTP-----EDKCHCCQ--------FPAPLRPHVVWFGE-MPLGM 160 +C G + +C C ++P + +FGE +P Sbjct: 335 HAKCITCGAIFKGEKIFNHIKKLQVPRCSKCWEDVQEAELIYGVIKPTITFFGEDLPERF 394 Query: 161 DEIY-MALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYG 219 ++ L AD+ I GTS +V P AG V + H + + +G+ F + G Sbjct: 395 HRLHSKDLKNADMVIVSGTSLNVNPVAGLVEKVPSHVPKILINKDQIDDMGSLFNLRLIG 454 Query: 220 PASQVVPEFVEKL 232 +VV + L Sbjct: 455 LCDEVVAWISKCL 467 >UniRef50_B0CZ35 Class I sirtuins SIR2 family protein n=2 Tax=Agaricales RepID=B0CZ35_LACBS Length = 395 Score = 221 bits (565), Expect = 1e-56, Method: Composition-based stats. Identities = 61/252 (24%), Positives = 98/252 (38%), Gaps = 28/252 (11%) Query: 3 KPRVLVLTGAGISAESGIRTFRAAD--------GLWEEHRVEDVATPEG------FDRDP 48 ++++ GAG+S +GI FR+ L+ ++ PE F R+P Sbjct: 36 CKNIVLMLGAGVSTSAGIPDFRSPGTGQSRSSHYLFSNLARLNLPHPEAVFEISFFRRNP 95 Query: 49 ELVQAFYNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNT--NV 106 FY +L + +P AH + L + + TQNID L RAG + Sbjct: 96 ---VPFYTLAH-ELYPGKFRPTIAHSFIRLLAEH-SLLYQCFTQNIDTLERRAGVPDGKI 150 Query: 107 IHMHGELLKVRCSQSGQVLD---WTGDVTPEDKCHCCQFPAPLRPHVVWFGE-MPLGMDE 162 I HG RC + D + + C + ++P +V+FGE +P+ Sbjct: 151 IEAHGSFATQRCIDCEEPFDDEVMKQHIKDKKIATCEECGGLVKPDIVFFGESLPINFIR 210 Query: 163 IYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEP--SQVGNEFAEKYYGP 220 L AD+ I +GTS V P A V + V +NL+ S G Sbjct: 211 AIPLLQEADLLIVMGTSLTVQPFASLVERV-DNSCPRVLINLDRVGSIGSRSDDVVLLGK 269 Query: 221 ASQVVPEFVEKL 232 +V + ++L Sbjct: 270 CDDIVRDLCKEL 281 >UniRef50_D2RWQ5 Silent information regulator protein Sir2 n=2 Tax=Halobacteriaceae RepID=D2RWQ5_9EURY Length = 271 Score = 221 bits (564), Expect = 1e-56, Method: Composition-based stats. Identities = 73/255 (28%), Positives = 108/255 (42%), Gaps = 30/255 (11%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQP 65 V+ TGAGISA SG+ TFR G+WE+ E T F DP +R++ Sbjct: 17 VVAFTGAGISAPSGVPTFRGDGGVWEKFD-EGQFTYGRFRSDPAGFWDDRVDLQREMFAE 75 Query: 66 EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGN---------------------- 103 QPNAAH ALA + G ++TQN D LH +A + Sbjct: 76 VYQPNAAHEALAAM-GRDGHLEAILTQNTDGLHAQAADAVSGDSSGDSDGADANGDAADD 134 Query: 104 -TNVIHMHGELLKVRCSQSGQVLDWT---GDVTPEDKCHCCQFPAPLRPHVVWFGEMPLG 159 T ++ +HG +VRC+ G+ D + C +P VV FG+ G Sbjct: 135 NTTLLELHGNARRVRCTDCGRRRDADPVFDRAAEGELPPTCDCGGVFKPDVVLFGQQLPG 194 Query: 160 --MDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKY 217 + +D+F+A+G+S V PAA +A GA +NLE + V + Sbjct: 195 TVIQRARSLARESDVFLAVGSSLVVEPAASLPRQAASTGATLGIVNLESTPVDDAADVVR 254 Query: 218 YGPASQVVPEFVEKL 232 ++V+P E + Sbjct: 255 REDVTEVLPRLRELV 269 >UniRef50_A9BHU8 Silent information regulator protein Sir2 n=3 Tax=Bacteria RepID=A9BHU8_PETMO Length = 256 Score = 221 bits (564), Expect = 2e-56, Method: Composition-based stats. Identities = 54/210 (25%), Positives = 95/210 (45%), Gaps = 12/210 (5%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEE---HRVEDVATPEGFDRDPELVQAFYNARR 59 + VL+GAG+S +GI FR +G++ + E + + F DP L F+ Sbjct: 15 SNSIAVLSGAGMSTNAGIPDFRGPNGIYTKANIENPERIFDLDYFYLDPSLFYKFHKKFL 74 Query: 60 RQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCS 119 + + E P H L +L+ G +VTQNID+LH++AG+ V +HG K C+ Sbjct: 75 EYITKAE--PTFTHKFLVQLE-KEGKLKGIVTQNIDSLHQKAGSKKVYEIHGGCWKNYCT 131 Query: 120 QSGQVL---DWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAI 176 + + + + E C ++P +V+FGE + E + + +++ + + Sbjct: 132 KCKRKYSQEEILEKMNNEVVPKCDNCGGVIKPDIVFFGEPVKYLTESEILMKNSELVLVL 191 Query: 177 GTSGHVYPAAGFVHEAKLHGAHTVELNLEP 206 G+S V PAA K + +N Sbjct: 192 GSSLAVIPAAMLPSLTK---GKIIVVNKGE 218 >UniRef50_B0D7T5 Predicted protein n=3 Tax=Agaricales RepID=B0D7T5_LACBS Length = 332 Score = 221 bits (563), Expect = 2e-56, Method: Composition-based stats. Identities = 85/270 (31%), Positives = 119/270 (44%), Gaps = 51/270 (18%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADG-LWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 +L+L+GAG+SA SGI T+R+AD LW ATP+ F +DP V +Y+ RR++ Sbjct: 54 SKNILILSGAGLSAASGIPTYRSADESLWNNFDPTAYATPQAFAKDPSGVWRWYHNRRKE 113 Query: 62 LQQPEIQPNAAHLALAKLQ--DALGDRF-------LLVTQNIDNL---------HERAGN 103 + +PN AH ALA L AL L +TQN+D+L E A Sbjct: 114 YL--KAKPNNAHRALATLALPSALSRIAPCSMSQPLHITQNVDSLSLRLLESLSPEAA-- 169 Query: 104 TNVIHMHGELLKVRCSQSGQV-----------LDWTGDVTPEDKCHCCQ----------- 141 +I MHG + +C+ +V LD D + CQ Sbjct: 170 EGLIEMHGSIFVTKCTSCQKVMRSYAPSLASALDGDEDSNAKRDVPLCQLPKCGGDSWAG 229 Query: 142 ------FPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLH 195 LRP VVWFGEMP M E+ +S D+ + +GTS V PA+ F + K + Sbjct: 230 SNRYGNCGGLLRPEVVWFGEMPPLMGEVSRKMSQCDLLLVVGTSSTVLPASSFATQVKAN 289 Query: 196 GAHTVELNLEPSQVGNEFAEKYYGPASQVV 225 G NL S +E + GP + Sbjct: 290 GGKVAVFNLNRSTGDDEADFLFLGPCETTL 319 >UniRef50_D2RCH9 Transcriptional regulator, Sir2 family n=7 Tax=Bifidobacteriaceae RepID=D2RCH9_GARVA Length = 257 Score = 220 bits (561), Expect = 4e-56, Method: Composition-based stats. Identities = 70/249 (28%), Positives = 107/249 (42%), Gaps = 19/249 (7%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEH-RVEDVATPEGFDRDPELVQAFYNARRR 60 + ++VLTGAGIS +GI FR DG+W +H V + F E + ++ Sbjct: 9 KAHHIVVLTGAGISTSAGIPDFRGPDGVWTKHPEQMSVYDIDAFLSSKEERVYSWRWQKE 68 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTN--VIHMHGELLKVRC 118 QP AH AL KL+ A G L+ TQN D LHE+AGN ++++HG + C Sbjct: 69 SPVW-NAQPGTAHKALVKLEKA-GMLDLIATQNFDALHEKAGNNPDIIVNLHGSIGTSHC 126 Query: 119 SQSGQVL---DWTGDVTPEDKCHCCQ---------FPAPLRPHVVWFGEMPL--GMDEIY 164 D D+ HC + ++ VV+FGE M+ Sbjct: 127 MSCHASYKTADIMADLDEHPDPHCRRTLPYRSNMPCNGLIKTDVVYFGEALPEGAMERSA 186 Query: 165 MALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQV 224 A+ AD IG++ V+PAA V A G +NL +Q ++ Sbjct: 187 QAIVKADELWVIGSTLEVFPAASLVPLAARAGVPITIMNLGSTQYDYLAERIIREDIAKA 246 Query: 225 VPEFVEKLL 233 +P+ V++ + Sbjct: 247 LPKLVDETI 255 >UniRef50_A7EC18 Putative uncharacterized protein n=1 Tax=Sclerotinia sclerotiorum 1980 UF-70 RepID=A7EC18_SCLS1 Length = 446 Score = 220 bits (561), Expect = 4e-56, Method: Composition-based stats. Identities = 65/247 (26%), Positives = 95/247 (38%), Gaps = 21/247 (8%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAA-DGLWEEHRVEDVATPEG------FDRDPELVQAF 54 + ++VLTGAGIS +GI FR+ G++ D+ E F +P F Sbjct: 35 QAKNIVVLTGAGISTSAGIPDFRSPETGIYANLAELDLPYAEAVFDIDFFRENPA---PF 91 Query: 55 YNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGE 112 Y ++L + P +H A L + G +L TQNID L RAG + VI HG Sbjct: 92 Y-VLAKELYPGQFYPTISH-AFVALIEKKGLLRMLFTQNIDCLERRAGVSSEKVIEAHGS 149 Query: 113 LLKVRCSQSGQVL--DWTGDVTPEDKCHCC---QFPAPLRPHVVWFGE-MPLGMDEIYMA 166 RC D E C Q ++P +V+FGE +P M Sbjct: 150 FATQRCIDCKTEYPDDMMKKAIQEGDPATCLVPQCGGLVKPDIVFFGEQLPEAFHSHKMI 209 Query: 167 LSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAE-KYYGPASQVV 225 + AD+ I +GTS V P A + + G+ + G V Sbjct: 210 PATADLIIVMGTSLSVQPFAMLPSLPADTVPRLLFNMISVGDFGSRLDDVVVLGDCDTGV 269 Query: 226 PEFVEKL 232 + + L Sbjct: 270 RKLADAL 276 >UniRef50_A3LRA1 Transcriptional regulatory protein n=4 Tax=Saccharomycetales RepID=A3LRA1_PICST Length = 311 Score = 220 bits (560), Expect = 4e-56, Method: Composition-based stats. Identities = 77/302 (25%), Positives = 128/302 (42%), Gaps = 73/302 (24%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 +++ L GAG+S SG+ TFR + GLW+ + D+ATP+ F DP LV FY+ RR Sbjct: 15 CRKIVALVGAGLSVSSGLPTFRGSQGLWKNFNMIDLATPDAFYIDPGLVWQFYSWRR--Y 72 Query: 63 QQPEIQPNAAHLALAKLQDAL-----GDRFLLVTQNIDNLHERAGN--TNVIHMHGELLK 115 + +PN HLAL+ L + ++ +TQN+D L R+G+ N+ +HG L Sbjct: 73 NALQAKPNKGHLALSALSNLATRKDSNLEYITITQNVDGLSSRSGHAKENLYEIHGSLFN 132 Query: 116 VRCSQ--S-----------------GQVLDWTGDVTPE---------------------- 134 + C+ G ++ Sbjct: 133 LNCTSFMCNYVDRNNLKHPLTKALEGTEYEYDRKNRKRSLEEDDSSHQVDYSISPQFRPV 192 Query: 135 --------DKCHCCQFPAPLRPHVVWFGE-MPLG----MDEIYMALSMADIFIAIGTSGH 181 +C C+ + LRP VVWFGE +PL +D + + D+ + IGTSG Sbjct: 193 KNIPESELPQCPVCKDGSLLRPGVVWFGESLPLNVMNSVDNFIESNNSVDLILVIGTSGT 252 Query: 182 VYPAAGFVHEAKLHGAHTVELNLEPSQVGNEF-------AEKYYGPASQVVPEFVEKLLK 234 VYPA +V K+ G N + + + + G A++++P ++ ++ Sbjct: 253 VYPANSYVDRVKVKGGKVAIFN---TDIEEDILQGIVKDTWGFRGDAAELLPIALKPVIG 309 Query: 235 GL 236 + Sbjct: 310 EV 311 >UniRef50_A0NQ49 Silent information regulator protein Sir2 n=2 Tax=Labrenzia RepID=A0NQ49_9RHOB Length = 260 Score = 219 bits (559), Expect = 6e-56, Method: Composition-based stats. Identities = 70/242 (28%), Positives = 107/242 (44%), Gaps = 19/242 (7%) Query: 4 PRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL- 62 +++ LTGAGIS ESGI FR+ G+W + + + F D + ++ R Sbjct: 23 RQIVALTGAGISTESGIPDFRSPGGIWSKRQP---VQYQDFVDDEDSRLEDWDRRLEDWD 79 Query: 63 -------QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTN--VIHMHGEL 113 + +PNAAH AL L + G L+TQN+D LH+RAG + ++ +HG Sbjct: 80 RRSEMMDYFCKAEPNAAHFALTTLARS-GKLVCLITQNVDGLHQRAGFPDDLLVEIHGNS 138 Query: 114 LKVRCSQSGQVLDWTGDVTPED---KCHCCQFPAPLRPHVVWFGE-MPLG-MDEIYMALS 168 C G + D C Q L+ V+ FG+ MP + A S Sbjct: 139 TFASCLSCGARAELEAQKPAVDAGESPRCSQCDGLLKAAVISFGQQMPERELQRAAEAAS 198 Query: 169 MADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEF 228 D+F+ +G+S V+PAA A GA V LN + + + + + P +Q F Sbjct: 199 ACDLFLVLGSSLVVHPAAQLPAVAVQSGAELVILNGQETPLDSYASTIVRTPLAQTFAGF 258 Query: 229 VE 230 E Sbjct: 259 GE 260 >UniRef50_D1B334 Silent information regulator protein Sir2 n=2 Tax=Campylobacterales RepID=D1B334_SULD5 Length = 230 Score = 219 bits (558), Expect = 7e-56, Method: Composition-based stats. Identities = 88/235 (37%), Positives = 128/235 (54%), Gaps = 9/235 (3%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQ 64 +V++ +GAGISAESG+ TFR ADGLWE++R+E++ + E AFY+ARR QL Sbjct: 3 KVVIFSGAGISAESGLSTFRDADGLWEKYRIEEICQAGCLSWNRENTLAFYDARREQLTS 62 Query: 65 PEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQV 124 ++PN AH ALAKLQ+ + ++TQN+D+L ERAG +V+H+HG L ++RC Q G Sbjct: 63 --VKPNTAHYALAKLQECYPNDIDIITQNVDDLFERAGCKDVLHLHGFLPRLRCEQCGAT 120 Query: 125 LDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGHVYP 184 G E C RP +V+FGE + +Y A+ + IG+SG+V Sbjct: 121 -QIIGYAKQERTFTCKNCGGSFRPDIVFFGEAAPMYEHLYEAMEDCQFLVIIGSSGNVIA 179 Query: 185 AAGFVHEAKLHGAHTVELNLEPSQVGNE--FAEKYYGPASQVVPEFVEKLLKGLK 237 F K + NLE S NE + + Y A++ V E V + + L Sbjct: 180 MDHFALHVKHS----ILNNLEKSDAINERVYTKVLYKKATEAVDEIVGDVERFLG 230 >UniRef50_A9NEY3 Putative uncharacterized protein n=1 Tax=Acholeplasma laidlawii PG-8A RepID=A9NEY3_ACHLI Length = 236 Score = 218 bits (557), Expect = 9e-56, Method: Composition-based stats. Identities = 69/233 (29%), Positives = 109/233 (46%), Gaps = 18/233 (7%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWE----EHRVEDVATPEGFDRDPELVQAFYNAR 58 ++ GAG+S ESGI+ FR+ DGL+ +R ED+ + F + FY Sbjct: 13 SNYIVFFGGAGVSTESGIKDFRSKDGLYSQKFKNYRPEDILSRSFFFNH---TKDFYEYF 69 Query: 59 RRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRC 118 RR I+PN AH+ L +++G ++TQNID LH+ AG+ NV+ +HG + Sbjct: 70 RRHFLDTGIKPNKAHMWLKD-AESIGKVKCVITQNIDGLHQMAGSKNVVELHGSAHRYYT 128 Query: 119 SQSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMD---EIYMALSMADIFIA 175 + Q +D + + ++P VV + E PL + + +S AD I Sbjct: 129 VKKKQPIDGLTYILNTEDIPVDSEGDLIKPDVVLYEE-PLNSEVVRKAIEEISKADTLIV 187 Query: 176 IGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEF 228 GTS VYPAA F+ K G H + +N E +F G +++ + Sbjct: 188 AGTSLTVYPAASFIEYFK--GKHLIVINKE----YMQFKHFIEGQVGEILSQI 234 >UniRef50_Q9Y6E7 NAD-dependent ADP-ribosyltransferase sirtuin-4 n=33 Tax=Deuterostomia RepID=SIRT4_HUMAN Length = 314 Score = 218 bits (557), Expect = 9e-56, Method: Composition-based stats. Identities = 69/262 (26%), Positives = 109/262 (41%), Gaps = 40/262 (15%) Query: 3 KPRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 R+LV+TGAGIS ESGI +R+ GL+ + F R + Q ++ R Sbjct: 54 SKRLLVMTGAGISTESGIPDYRSEKVGLYARTDRRPI-QHGDFVRSAPIRQRYW--ARNF 110 Query: 62 LQQPEI---QPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRC 118 + P+ QPN AH AL+ + LG + LVTQN+D LH +AG+ + +HG + +V C Sbjct: 111 VGWPQFSSHQPNPAHWALSTWE-KLGKLYWLVTQNVDALHTKAGSRRLTELHGCMDRVLC 169 Query: 119 SQSGQVLDW------------------------------TGDVTPEDKCHCCQFPAPLRP 148 G+ V C Q L+P Sbjct: 170 LDCGEQTPRGVLQERFQVLNPTWSAEAHGLAPDGDVFLSEEQVRSFQVPTCVQCGGHLKP 229 Query: 149 HVVWFGE--MPLGMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEP 206 VV+FG+ P +D ++ + AD + +G+S VY F+ A LN+ P Sbjct: 230 DVVFFGDTVNPDKVDFVHKRVKEADSLLVVGSSLQVYSGYRFILTAWEKKLPIAILNIGP 289 Query: 207 SQVGNEFAEKYYGPASQVVPEF 228 ++ + K +++P Sbjct: 290 TRSDDLACLKLNSRCGELLPLI 311 >UniRef50_C9M9P4 Transcriptional regulator, Sir2 family n=1 Tax=Jonquetella anthropi E3_33 E1 RepID=C9M9P4_9BACT Length = 250 Score = 218 bits (557), Expect = 1e-55, Method: Composition-based stats. Identities = 64/237 (27%), Positives = 100/237 (42%), Gaps = 13/237 (5%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVE--DVATPEGFDRDPELVQAFYNARRR 60 R + TGAG+S ++G+ FR +GL+ V+ + + F DP F+ R+ Sbjct: 17 SRRAVAFTGAGVSTDAGLPDFRGPNGLYRRSDVDASRLFDIDAFYEDPSYYYRFHRQLRK 76 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 L I+P H LA+ + + G LVTQN D LHE AG+ V +HG + C + Sbjct: 77 IL--AGIRPTVTHRFLAQWEQS-GRLAALVTQNFDGLHEAAGSKRVFPVHGTVATNTCLR 133 Query: 121 SGQVLDWT--GDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGT 178 G+ + E C ++P VV+FGE + E + A AD + +GT Sbjct: 134 CGRGFSAAQLDEFLAEQGVPHCPCGGVIKPDVVFFGESVKFLSESFAAAEAADFMLVLGT 193 Query: 179 SGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFA-EKYYGPASQVVPEFVEKLLK 234 S V PA A V +N + + E + +F +L + Sbjct: 194 SLTVAPACSVPALCP---APVVIVNKGAVHLSYPRSREILQADCD--LDDFFTQLSR 245 >UniRef50_A4QUX8 Putative uncharacterized protein n=1 Tax=Magnaporthe grisea RepID=A4QUX8_MAGGR Length = 460 Score = 218 bits (555), Expect = 2e-55, Method: Composition-based stats. Identities = 66/243 (27%), Positives = 100/243 (41%), Gaps = 19/243 (7%) Query: 4 PRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEG------FDRDPELVQAFYN 56 R+ V+TGAGIS +GI FR+ GL+ + PE F PE FY Sbjct: 40 KRITVMTGAGISTAAGIPDFRSPGTGLYSNLERLKLPEPEAVFDISFFRDRPE---PFY- 95 Query: 57 ARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGN--TNVIHMHGELL 114 ++L + QP +H +A L G + TQNID L +AG VI HG Sbjct: 96 VLAKELYPGKFQPTISHAFIALLSKK-GLLQMNFTQNIDCLERQAGVPGEKVIEAHGSFA 154 Query: 115 KVRCSQSGQVLDWTGDVTPEDK---CHCCQFPAPLRPHVVWFGE-MPLGMDEIYMALSMA 170 C + ++ + +K C ++P++V+FGE +P E ++ + Sbjct: 155 TQSCIECKELFPDDEMLLHVEKEIVPRCASCNGLVKPNIVFFGEPLPRTFSEKCHLVAES 214 Query: 171 DIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKY-YGPASQVVPEFV 229 D+ I IGTS VYP AG + + Q+G + G V + Sbjct: 215 DLAIIIGTSLTVYPFAGLPELVPRGSPRLLLNKVRVGQIGTRSDDVVELGSCDAGVRKLA 274 Query: 230 EKL 232 + L Sbjct: 275 DLL 277 >UniRef50_Q5V4Q5 NAD-dependent deacetylase n=3 Tax=Halobacteriaceae RepID=NPD_HALMA Length = 260 Score = 218 bits (555), Expect = 2e-55, Method: Composition-based stats. Identities = 78/233 (33%), Positives = 107/233 (45%), Gaps = 9/233 (3%) Query: 7 LVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQA-FYNARRRQLQQP 65 + LTGAG+S SGI +FR DG+WE H D D DP A + R Sbjct: 30 VALTGAGVSTASGIPSFRGDDGIWERHDPADF-HRRRLDADPAGFWADRLSLREAIYGDI 88 Query: 66 EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVL 125 + +PNAAH A +A G ++TQNID LH+ AG V+ +HG +V C G Sbjct: 89 DPEPNAAHEA-LAALEADGHLDAVLTQNIDGLHDAAGTDRVVELHGTHRRVVCDDCGHRR 147 Query: 126 D----WTGDVTPEDKCHCCQFPAPLRPHVVWFGE-MP-LGMDEIYMALSMADIFIAIGTS 179 D + D C RP VV FGE MP + M+E +D+F+A+G+S Sbjct: 148 DAEVVFEQAAESSDLPPRCDCGGVYRPDVVLFGEPMPDVAMNEAQRLARDSDVFLAVGSS 207 Query: 180 GHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 V PA+ A + V +N E + A +QV+P VE+L Sbjct: 208 LSVQPASLLPKIAAEGDSTLVVVNYEETPRDASAAHVLRADVTQVLPAIVERL 260 >UniRef50_Q9ZJW8 NAD-dependent deacetylase n=58 Tax=Bacteria RepID=NPD_HELPJ Length = 234 Score = 217 bits (554), Expect = 2e-55, Method: Composition-based stats. Identities = 87/190 (45%), Positives = 117/190 (61%), Gaps = 8/190 (4%) Query: 4 PRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQ 63 +++L+GAGISAESGI+TFR A GLWE H + +VA+P G+ ++P+ V FYN RRRQL Sbjct: 2 KNLVILSGAGISAESGIKTFRDAGGLWEGHDIMEVASPYGWKKNPQKVLDFYNQRRRQLF 61 Query: 64 QPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS-G 122 E+ PN AH ALA+L+ ++TQN+D+LHERAG++ ++H+HGELL VR + Sbjct: 62 --EVYPNKAHKALAELEKHYQVN--IITQNVDDLHERAGSSRILHLHGELLSVRSEKDPN 117 Query: 123 QVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGHV 182 V W D+ D Q A LRP +VWFGE + E + + I IGTS V Sbjct: 118 LVYRWEKDLNLGDLA---QDKAQLRPDIVWFGEEVPLLKEAVSLVKQVHLLIIIGTSLQV 174 Query: 183 YPAAGFVHEA 192 YPAA A Sbjct: 175 YPAASLYTHA 184 >UniRef50_UPI00015B57C0 PREDICTED: similar to GA18743-PA n=1 Tax=Nasonia vitripennis RepID=UPI00015B57C0 Length = 871 Score = 217 bits (554), Expect = 2e-55, Method: Composition-based stats. Identities = 61/265 (23%), Positives = 100/265 (37%), Gaps = 42/265 (15%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEH--RVEDVATPEG------FDRDPELVQAF 54 ++VLTGAG+S GI FR+ DG++ D+ P+ F +DP F Sbjct: 204 SKNIIVLTGAGVSVSCGIPDFRSRDGIYSRLAQDFPDLPDPQAMFDINYFSQDPRPFFKF 263 Query: 55 YNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELL 114 R++ + +P+ H + L+ +QNID L AG N+I HG Sbjct: 264 ----AREIYPGQFKPSPCHQFIKMLEKQK-KLLRNYSQNIDTLERVAGINNLIECHGSFA 318 Query: 115 KVRCSQSGQVL---DWTGDVTPEDKCHCCQF----------------------PAPLRPH 149 C++ + D ++ + C + ++P Sbjct: 319 TASCTKCKYQVKSDDVKAEIFAQTIPMCPKCQEQSLPSITDPTSSDNYRDIVAQGVMKPD 378 Query: 150 VVWFGE-MPLGM-DEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPS 207 +V+FGE +P D + + D+ I IG+S V P A H + +N E Sbjct: 379 IVFFGEGLPDAFHDAMASDKDVCDLLIVIGSSLKVRPVALIPSSIPSH-VPQILINRESL 437 Query: 208 QVGNEFAEKYYGPASQVVPEFVEKL 232 Q EF + G V+ + L Sbjct: 438 QH-LEFDVELLGDGDVVINQLCHML 461 >UniRef50_O96505 SIR2 n=15 Tax=Arthropoda RepID=O96505_DROME Length = 823 Score = 217 bits (553), Expect = 3e-55, Method: Composition-based stats. Identities = 63/269 (23%), Positives = 100/269 (37%), Gaps = 44/269 (16%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEE--HRVEDVATPEG------FDRDPELVQA 53 + +++VLTGAG+S GI FR+ +G++ H D+ P+ F RDP + Sbjct: 218 KSQKIIVLTGAGVSVSCGIPDFRSTNGIYARLAHDFPDLPDPQAMFDINYFKRDP---RP 274 Query: 54 FYNARRRQLQ-QPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGE 112 FY R + + QP+ H + L+ G TQNID L AG VI HG Sbjct: 275 FYKFAREIYPGEFQFQPSPCHRFIKMLETK-GKLLRNYTQNIDTLERVAGIQRVIECHGS 333 Query: 113 LLKVRCSQSGQVLDWT---GDVTPEDKCHCCQF------------------------PAP 145 C++ + D+ + C Q Sbjct: 334 FSTASCTKCRFKCNADALRADIFAQRIPVCPQCQPNKEQSVDASVAVTEEELRQLVENGI 393 Query: 146 LRPHVVWFGEMPLGMDEIYMALSM--ADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELN 203 ++P +V+FGE MA D+ I IG+S V P A + +N Sbjct: 394 MKPDIVFFGEGLPDEYHTVMATDKDVCDLLIVIGSSLKVRPVAHIPSSIPAT-VPQILIN 452 Query: 204 LEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 E +F + G + ++ + +L Sbjct: 453 REQLHH-LKFDVELLGDSDVIINQICHRL 480 >UniRef50_A0C6J0 Chromosome undetermined scaffold_152, whole genome shotgun sequence n=1 Tax=Paramecium tetraurelia RepID=A0C6J0_PARTE Length = 449 Score = 216 bits (552), Expect = 4e-55, Method: Composition-based stats. Identities = 71/242 (29%), Positives = 106/242 (43%), Gaps = 20/242 (8%) Query: 4 PRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATP------EGFDRDPELVQAFYN 56 RV VL GAG+S +GI FR GL+ + + ++ +P E F ++PE AFY Sbjct: 210 QRVCVLAGAGMSVAAGIPDFRTPGTGLYSQIQKYNLPSPESVFEIEYFKKNPE---AFYC 266 Query: 57 ARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGN--TNVIHMHGELL 114 + L + +P AH L L D+ G TQNID L AG VI HG + Sbjct: 267 VAKEFLLSFDAKPTLAHKFLKFL-DSRGQLLKCFTQNIDGLELDAGVSQDKVIQAHGHMR 325 Query: 115 KVRCSQSGQVL---DWTGDVTPEDKCHCCQFP--APLRPHVVWFGE-MPLGMDEIYMALS 168 RC + + + D+ + D C + P ++P VV+FGE +P + L Sbjct: 326 TARCIECQEEVSIKDFMSHIKKGDIHRCEKCPKKGLVKPDVVFFGEGLPGEFFYSWNCLK 385 Query: 169 MADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEF 228 AD+ I IGTS V P A V + + +N E G + G + + Sbjct: 386 DADLLIVIGTSLKVMPFAASVAKVGPT-TPIILINRENVLNGRKNLLHLDGDIEENCKKL 444 Query: 229 VE 230 ++ Sbjct: 445 LQ 446 >UniRef50_Q07FY7 Sirtuin (Silent mating type information regulation 2 homolog) 3 (S. cerevisiae) n=3 Tax=Xenopus RepID=Q07FY7_XENTR Length = 401 Score = 216 bits (551), Expect = 5e-55, Method: Composition-based stats. Identities = 60/212 (28%), Positives = 95/212 (44%), Gaps = 13/212 (6%) Query: 5 RVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEG-FDRDPELVQA--FYNARRR 60 ++V+ GAGIS SGI FR GL++ + D+ PE FD + + F++ + Sbjct: 128 NIIVMAGAGISTASGIPDFRTPGSGLYDNLQKYDIPYPEAIFDINYFVCNPNPFFHLA-K 186 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELLKVRC 118 +L + +PN H + L D G TQNID L AG ++ +HG C Sbjct: 187 ELFPGKYKPNLVHYFIKLLHDK-GLLLRCYTQNIDGLERLAGIPVEKIVEVHGTFFSASC 245 Query: 119 SQSGQVLDWT--GDVTPEDKCHCCQ-FPAPLRPHVVWFGE-MPLGMDEIYMALSMADIFI 174 S ++ + CC+ P++P +V+FGE +P + Y AD+ I Sbjct: 246 SLCYTPFPANEAKELIFDGNPPCCKFCAGPVKPDIVFFGEDLPQTFTQAYQDFPKADLLI 305 Query: 175 AIGTSGHVYPAAGFVHEAKLHGAHTVELNLEP 206 +GTS + P A V+ K + +N E Sbjct: 306 IMGTSLKIEPFASLVNTVKPS-IPRLLINREK 336 >UniRef50_Q3A6W7 NAD-dependent protein deacetylases, SIR2 family n=2 Tax=Pelobacter RepID=Q3A6W7_PELCD Length = 278 Score = 216 bits (550), Expect = 6e-55, Method: Composition-based stats. Identities = 67/236 (28%), Positives = 103/236 (43%), Gaps = 26/236 (11%) Query: 6 VLVLTGAGISAESGIRTFRAADGLW--EEHRVEDVATPEGFDRDPELVQAFYNARRRQLQ 63 V+ L+GAGIS +GI FR GL+ + E V + F R+P F R Sbjct: 35 VVTLSGAGISTAAGIPDFRGPQGLYVTRRYDPEKVFDIDWFHREPRYFYEF--TRDFVST 92 Query: 64 QPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQ 123 I+P H LA L+ A G L+TQNID LH+ AG+ VI +HG +C G+ Sbjct: 93 VKAIRPTFTHRFLAGLEKAGG-LAGLITQNIDMLHQLAGSRKVIDLHGSYRSAQCLFCGK 151 Query: 124 VLD------WTGDVTPEDKCH---CCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFI 174 + W ++ K C + L+P +V+FGEM + ++ D+ + Sbjct: 152 SYEALSYTWWERAMSTSSKPPLAYCSACNSVLKPDIVFFGEMVHAFEAAEQLIAQCDLLL 211 Query: 175 AIGTSGHVYPAAGFVHEAKLHGAHTVELNLE-----PSQ----VGNEFAEKYYGPA 221 +G+S V PA+ + + A TV +N P+ V + + A Sbjct: 212 VLGSSLKVTPASLLPYHTQ---ATTVVVNRGAVMLPPAPHRFFVDGDLDVYFRAVA 264 >UniRef50_A1ZHW6 NAD-dependent deacetylase n=2 Tax=Microscilla marina ATCC 23134 RepID=A1ZHW6_9SPHI Length = 279 Score = 216 bits (550), Expect = 6e-55, Method: Composition-based stats. Identities = 80/262 (30%), Positives = 129/262 (49%), Gaps = 32/262 (12%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWE----EHRVEDVATPEGFDRDPELVQAFYNA 57 ++ +++VLTGAGISAESGI TFR +G W+ ++ +++ T + F ++P+ V +Y Sbjct: 17 DQAKMVVLTGAGISAESGIPTFRGKEGYWKIGSVNYQPQEIGTMKMFKQNPQEVWKWYLF 76 Query: 58 RRRQLQQPEIQPNAAHLALAKLQDAL-GDRFLLVTQNIDNLHERAGN--TNVIHMHGELL 114 R QPN H A+A+++ L G RF LVTQN+D LH RAG+ N + +HG+L Sbjct: 77 RHTVCNNS--QPNPGHYAVAEMEKILGGKRFTLVTQNVDGLHFRAGSTFKNTLLIHGDLT 134 Query: 115 KVRCSQ--SG-QVLDWTGDVTPE-----------DKCHCCQFPAPLRPHVVWFG----EM 156 VRCS+ ++L + + P+ ++ C A RPHV+WF E Sbjct: 135 HVRCSKDSCDTELLPFPEGIAPKTRESAISLEEWERLRCPSCGALTRPHVLWFDEYYNEK 194 Query: 157 PLGMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVG-----N 211 + AD+ I +GTSG + A + V +NL+ S N Sbjct: 195 YYKYETALHKNREADLLIVVGTSGATNLPNKMYYNALNNNKQIVVVNLDSSIFSRTLEAN 254 Query: 212 EFAEKYYGPASQVVPEFVEKLL 233 + G + +++PE + + Sbjct: 255 QTGHVLLGKSGEILPEILAAIK 276 >UniRef50_Q54GV7 NAD(+)-dependent deacetylase, silent information regulator protein family protein n=1 Tax=Dictyostelium discoideum RepID=Q54GV7_DICDI Length = 542 Score = 216 bits (550), Expect = 7e-55, Method: Composition-based stats. Identities = 58/248 (23%), Positives = 96/248 (38%), Gaps = 23/248 (9%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEH-------RVEDVATPEGFDRDPELVQAFY 55 ++++TGAG+S GI FR+ G++E R E + +P F Sbjct: 300 SKNIVIITGAGVSVSCGIPDFRSKGGVYETIEKKYNLPRPESLFDIHYLRANPLPFFEF- 358 Query: 56 NARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGEL 113 +++ +P+ H + KL D G TQNID L AG +++ HG Sbjct: 359 ---AKEIFPGNHKPSPTHSFI-KLLDEKGKLLRNYTQNIDTLEHVAGIDREKLVNCHGSF 414 Query: 114 LKVRCSQSGQVLDWTG-----DVTPEDKCHCCQFP-APLRPHVVWFGE-MPLGMDEIY-M 165 C +D T C C + ++P +V+FGE +P D+ Sbjct: 415 STATCITCKLTVDGTTIRDTIMKMEIPLCQQCNDGQSFMKPDIVFFGENLPDRFDQCVLK 474 Query: 166 ALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVV 225 + D+ I +G+S V P + + +N E +EF Y G Q V Sbjct: 475 DVKDIDLLIVMGSSLQVQPVSLLPDIVDKQ-IPQILINRELVAQPHEFDYVYLGDCDQFV 533 Query: 226 PEFVEKLL 233 + + K+ Sbjct: 534 QDLLNKVK 541 >UniRef50_A2QWZ2 Function: human SIRT5 belongs to the Sir2-like proteins n=1 Tax=Aspergillus niger CBS 513.88 RepID=A2QWZ2_ASPNC Length = 258 Score = 215 bits (549), Expect = 8e-55, Method: Composition-based stats. Identities = 84/245 (34%), Positives = 124/245 (50%), Gaps = 18/245 (7%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 RV+ L GAGISA SG+ TFR A GLW + D+ATPE FD +P+LV FY+ RR Sbjct: 21 CRRVIALLGAGISASSGLPTFRGAGGLWRSYDATDLATPEAFDANPDLVWQFYSYRRHM- 79 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG---NTNVIHMHGELLKVRCS 119 + QPN AH ALA+L F+ ++QN+D+ R G + ++ G Sbjct: 80 -ALKAQPNRAHYALAELARK-NKDFITLSQNVDD---RTGEEASRSIASALGNNEDEADV 134 Query: 120 QSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALS--MADIFIA 175 +V C C+ LRP VVWFGE +D + L+ D+ + Sbjct: 135 SDERVPLSAVPYEELPHCPECKD-GLLRPGVVWFGESLPSHTIDYVDEWLNKGKVDLILV 193 Query: 176 IGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNE----FAEKYYGPASQVVPEFVEK 231 +GTS VYPAAG+V +A+ GA +N++ + VG+ + G A +VPE ++ Sbjct: 194 VGTSSRVYPAAGYVDKARSKGARVAVVNMDRNDVGSSGLKPGDWFFEGDAGTIVPEILKG 253 Query: 232 LLKGL 236 ++ + Sbjct: 254 VIGDI 258 >UniRef50_Q9FE17 Sir2-like protein n=13 Tax=Viridiplantae RepID=Q9FE17_ARATH Length = 473 Score = 215 bits (548), Expect = 1e-54, Method: Composition-based stats. Identities = 60/241 (24%), Positives = 96/241 (39%), Gaps = 29/241 (12%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 + ++V TGAGIS GI FR G+W R P+ F+ A Sbjct: 43 KSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQREGKDL--------PKASLPFHRAM--- 91 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELLKVRCS 119 P+ H+AL +L+ A G +++QN+D LH R+G + +HG+ C Sbjct: 92 -------PSMTHMALVELERA-GILKFVISQNVDGLHLRSGIPREKLSELHGDSFMEMCP 143 Query: 120 QSGQVL------DWTGDVTPEDKCHCCQFPAPLRPHVV-WFGEMPL-GMDEIYMALSMAD 171 G + G KC + A L+ V+ W +P +D AD Sbjct: 144 SCGAEYLRDFEVETIGLKETSRKCSVEKCGAKLKDTVLDWEDALPPKEIDPAEKHCKKAD 203 Query: 172 IFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEK 231 + + +GTS + PA + G V +NL+ + + +G +VV +E Sbjct: 204 LVLCLGTSLQITPACNLPLKCLKGGGKIVIVNLQKTPKDKKANVVIHGLVDKVVAGVMES 263 Query: 232 L 232 L Sbjct: 264 L 264 >UniRef50_B3RLQ5 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens RepID=B3RLQ5_TRIAD Length = 386 Score = 215 bits (548), Expect = 1e-54, Method: Composition-based stats. Identities = 64/258 (24%), Positives = 109/258 (42%), Gaps = 27/258 (10%) Query: 3 KPRVLVLTGAGISAESGIRTFRAA-DGLWEEHRVEDVATP------EGFDRDPELVQAFY 55 +L+L GAGIS SGI FR+ G++ + ++++P + F +P + FY Sbjct: 126 CKNILILAGAGISTSSGIPDFRSPKTGIYSILKNNNLSSPTDAFDIDYFRSNPAV---FY 182 Query: 56 NARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERA--GNTNVIHMHGEL 113 + L + +PN AH + L D G + TQNID L A ++ ++ HG Sbjct: 183 ELAKD-LYPGQYRPNYAHYFIKLLCDK-GLLGRMYTQNIDGLERLADIPSSKLVEAHGTF 240 Query: 114 LKVRCSQSGQVL--DWTGDVTPEDKCHCC-QFPAPLRPHVVWFGE-MPLGMDEIY-MALS 168 C+ + D+ C + ++P +V+FGE +P ++Y ++ Sbjct: 241 SSATCTCCKKTFNGDFIKSAIMNKIIPKCDRCSGIIKPDIVFFGENLPKRFYKLYKKDIA 300 Query: 169 MADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEP----SQVGNEFAEKYY-GPASQ 223 D+ I +GTS V P A V + V +N E ++ F + Y G Sbjct: 301 GCDLVIVMGTSLQVEPFASLVDKIPQR-TPRVLINKEIVGPFTRKKRRFTDIIYTGDIVD 359 Query: 224 VVPEFVEKLLKGLKAGSI 241 + E + GL+ I Sbjct: 360 GLKELAKN--AGLRDEMI 375 >UniRef50_C0S0X1 NAD-dependent deacetylase sirtuin-2 n=3 Tax=Paracoccidioides brasiliensis RepID=C0S0X1_PARBP Length = 447 Score = 214 bits (547), Expect = 2e-54, Method: Composition-based stats. Identities = 62/244 (25%), Positives = 95/244 (38%), Gaps = 21/244 (8%) Query: 4 PRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEG------FDRDPELVQAFYN 56 R++VLTGAGIS +GI FR+ D G++ ++ PE F ++P + FY+ Sbjct: 36 RRIVVLTGAGISTAAGIPDFRSPDTGIYANLARLNLPHPEAVFDISYFRKNP---RPFYS 92 Query: 57 ARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNT--NVIHMHGELL 114 + +P AH + L D G L TQNID L +AG ++ HG Sbjct: 93 LSKEMF-PGRYRPTIAHTFIKLLYDK-GLLLKLFTQNIDCLERQAGVPGGMIVEAHGSYA 150 Query: 115 KVRCSQSGQVLD---WTGDVTPEDKCHCCQFPAPLRPHVVWFGE-MPLGMDEIYMALSMA 170 C + D C + ++P +V+FGE +P + A Sbjct: 151 THSCIDCKSPYPDDLMRKAIESNDIPLCLKCCGFVKPDIVFFGESLPESFFMNRTLTTAA 210 Query: 171 DIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQ--VGNEFAEKYYGPASQVVPEF 228 ++ I +GTS V P A K G + +NL G V + Sbjct: 211 ELCIIMGTSLTVQPFASLPSLCKE-GVPRLLINLNRVGGLGSRPDDVLLLGECDDGVLKL 269 Query: 229 VEKL 232 + L Sbjct: 270 ADAL 273 >UniRef50_B2ATE5 Predicted CDS Pa_1_15580 n=4 Tax=Sordariomyceta RepID=B2ATE5_PODAN Length = 404 Score = 214 bits (547), Expect = 2e-54, Method: Composition-based stats. Identities = 67/247 (27%), Positives = 97/247 (39%), Gaps = 38/247 (15%) Query: 3 KPRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEG------FDRDPELVQAFY 55 R++V+TGAGIS +GI FR+ D GL+ D+ PE F +P + FY Sbjct: 34 AKRIVVMTGAGISTAAGIPDFRSPDTGLYANLASLDLPEPEAVFDLGFFKVNP---RPFY 90 Query: 56 NARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGEL 113 + L LA+ G L TQNID L AG +I HG Sbjct: 91 VLAKELL-------------LAE----KGLLHQLFTQNIDCLEREAGIPAEKIIEAHGSF 133 Query: 114 LKVRCSQSGQVLDWTGDVT-----PEDKCHCCQFPAPLRPHVVWFGE-MPLGMDEIYMAL 167 RC + D +C ++P +V+FGE +P + Sbjct: 134 ASQRCIECKTEFDAGKMREFVSQGEVPRCEDGGCKGLVKPDIVFFGEQLPKAFFDRRDMA 193 Query: 168 SMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPS-QVGNEFAEKY-YGPASQVV 225 AD+ + +GTS V+P AG V A V NLE +G + + G + V Sbjct: 194 EEADLVLVMGTSLQVHPFAGLVDLAAER-VPRVLFNLERVGSMGCQADDVLALGDCDEGV 252 Query: 226 PEFVEKL 232 ++L Sbjct: 253 RRLADEL 259 >UniRef50_Q9NTG7 NAD-dependent deacetylase sirtuin-3, mitochondrial n=38 Tax=Metazoa RepID=SIRT3_HUMAN Length = 399 Score = 214 bits (546), Expect = 2e-54, Method: Composition-based stats. Identities = 61/213 (28%), Positives = 90/213 (42%), Gaps = 13/213 (6%) Query: 3 KPRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEGFDRDPELVQ---AFYNAR 58 RV+V+ GAGIS SGI FR+ GL+ + D+ PE P F+ Sbjct: 137 CQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIFELPFFFHNPKPFFTLA 196 Query: 59 RRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELLKV 116 ++L +PN H L L D G L TQNID L +G + ++ HG Sbjct: 197 -KELYPGNYKPNVTHYFLRLLHDK-GLLLRLYTQNIDGLERVSGIPASKLVEAHGTFASA 254 Query: 117 RCSQSGQVL---DWTGDVTPEDKCHCCQFPAPLRPHVVWFGE-MPLGMDEIYMALSMADI 172 C+ + D DV + C ++P +V+FGE +P + MAD+ Sbjct: 255 TCTVCQRPFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADL 314 Query: 173 FIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLE 205 + +GTS V P A EA + +N + Sbjct: 315 LLILGTSLEVEPFASL-TEAVRSSVPRLLINRD 346 >UniRef50_Q7ZVK3 NAD-dependent deacetylase sirtuin-2 n=19 Tax=Eukaryota RepID=SIRT2_DANRE Length = 379 Score = 214 bits (545), Expect = 2e-54, Method: Composition-based stats. Identities = 57/222 (25%), Positives = 91/222 (40%), Gaps = 22/222 (9%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEG------FDRDPELVQAF 54 + ++ + GAGIS +GI FR+ GL+ + ++ PE F + PE F Sbjct: 73 KCKNIICMVGAGISTSAGIPDFRSPGTGLYANLQKYNLPYPEAIFQIDYFKKHPE---PF 129 Query: 55 YNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGE 112 + R +L + +P H + L+D G +QNID L AG ++I HG Sbjct: 130 FALAR-ELYPGQFKPTVYHYFIKMLKDK-GLLRRCYSQNIDTLERVAGLEGEDLIEAHGT 187 Query: 113 LLKVRCSQ--SGQVL--DWTGDVT-PEDKCHCCQFPAPLRPHVVWFGE-MPLGMDEIYMA 166 C + DW + E+ C + ++P +V+FGE +P A Sbjct: 188 FHTSHCVSFLCRKEYSMDWMKNQIFSEEIPKCDSCGSLVKPDIVFFGESLPSRFFTSMKA 247 Query: 167 -LSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPS 207 D+ I +GTS V P A V +N+E + Sbjct: 248 DFPQCDLLIIMGTSLQVQPFASLVSRVSNRCPRL-LINMEKT 288 >UniRef50_UPI00019255E8 PREDICTED: similar to sirtuin n=2 Tax=Hydra magnipapillata RepID=UPI00019255E8 Length = 320 Score = 213 bits (544), Expect = 3e-54, Method: Composition-based stats. Identities = 69/264 (26%), Positives = 110/264 (41%), Gaps = 42/264 (15%) Query: 3 KPRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 +V V+TGAG+S ESGI+ +R+ GL+ + + E F ++P Q ++ R Sbjct: 55 CSKVFVITGAGVSTESGIKDYRSDKVGLYATSKQRPIEYLE-FLKNPNKRQKYW--ARNY 111 Query: 62 LQQP---EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRC 118 L P QPN H L+ ++ G+ LVTQN+D+LH +AG+ V +HG +V C Sbjct: 112 LAWPIFSSFQPNVNHHFLSAMEKH-GNLHWLVTQNVDSLHLKAGSVRVTELHGSSARVVC 170 Query: 119 SQSGQVLDW--------------------------------TGDVTPEDKCHCCQFPAPL 146 G + D + C + L Sbjct: 171 LTCGNKISRVELQKQLQHINSNWRSISSLNEQGPDGDVFISESDASQFKMVDCHKCGGIL 230 Query: 147 RPHVVWFGE--MPLGMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNL 204 +P +V+FG+ P + Y LS D + IG+S VY + F+ AK LN+ Sbjct: 231 KPEIVFFGDNVSPTVKEFCYKMLSECDGVLVIGSSLQVYSSFRFIIAAKEKRIPIAILNI 290 Query: 205 EPSQVGNEFAEKYYGPASQVVPEF 228 ++ K A +V+P+ Sbjct: 291 GETRGDPYAYLKLPYRAGEVLPKL 314 >UniRef50_D2A3P1 Putative uncharacterized protein GLEAN_14968 n=1 Tax=Tribolium castaneum RepID=D2A3P1_TRICA Length = 612 Score = 213 bits (544), Expect = 3e-54, Method: Composition-based stats. Identities = 64/266 (24%), Positives = 116/266 (43%), Gaps = 40/266 (15%) Query: 5 RVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQ 63 ++LVLTGAGIS ESGI +R+ D GL+ V + F + ++ Q ++ R + Sbjct: 45 KILVLTGAGISTESGIPDYRSEDVGLYARTNHRPV-QYQEFLKSEKVRQRYW--ARNYIG 101 Query: 64 QPEI---QPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 P+ QPN H + + +++G +VTQN+D+LH +AG+ NVI +HG +V C + Sbjct: 102 WPKFSQTQPNITHY-IVQFLESVGKVGCVVTQNVDSLHFKAGSGNVIELHGTAFRVICLK 160 Query: 121 SGQVLDW----------------TGDVTPED--------------KCHCCQFPAPLRPHV 150 G+ D T + D C L+P + Sbjct: 161 CGKNYDRHKVQEKLIGLNPDLRETSQMIRPDGDVEISQEKVENFKPPFCDHCQGVLKPDI 220 Query: 151 VWFGEMPL--GMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQ 208 +FG+ +D++ ++ +D + +G+S V+ + +A +N+ P++ Sbjct: 221 TFFGDNVPKERVDKVRQNVTQSDAILVLGSSLSVFSGYRIILQAVEEKKDVAIVNIGPTR 280 Query: 209 VGNEFAEKYYGPASQVVPEFVEKLLK 234 K +VP + ++K Sbjct: 281 ADKHAKLKISARYGLIVPNKDKAVIK 306 >UniRef50_B6GXN1 Pc12g08000 protein n=1 Tax=Penicillium chrysogenum Wisconsin 54-1255 RepID=B6GXN1_PENCW Length = 267 Score = 213 bits (544), Expect = 4e-54, Method: Composition-based stats. Identities = 85/248 (34%), Positives = 118/248 (47%), Gaps = 18/248 (7%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 R++ L GAGISA SG+ TFR A GLW H +ATPE FD P LV FY+ RR Sbjct: 24 CKRIVALLGAGISASSGLPTFRGAGGLWRSHDATSLATPEAFDETPGLVWQFYSYRRHMA 83 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERA-------GNTNVIHMHGELLK 115 Q + PN AH ALA+L D L +QN+D L+ A + + + Sbjct: 84 LQAD--PNRAHYALAELARRNEDFLTL-SQNVDGLNPSATDKTGEQASKAIGEALDDTST 140 Query: 116 VRCSQSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGE-MPLGMDEI---YMALSMAD 171 T +C C+ LRP VVWFGE +P ++A D Sbjct: 141 EVDISDASNPIATVAREDLPQCPKCED-GLLRPGVVWFGEPLPEKTIRAVDKWIAAGPVD 199 Query: 172 IFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEF---AEKYYGPASQVVPEF 228 + + IGTS V+PAAG+VHEA+ GA N++P+ E + G A +VPE Sbjct: 200 LCLVIGTSAKVFPAAGYVHEARSQGARVAVCNMDPNDTPGELHYGDWFFQGDAGVIVPEI 259 Query: 229 VEKLLKGL 236 ++ ++ + Sbjct: 260 LKSVIGDI 267 >UniRef50_B3WAV7 NAD-dependent deacetylase (Regulatory protein SIR2 homolog) n=18 Tax=Lactobacillales RepID=B3WAV7_LACCB Length = 230 Score = 213 bits (543), Expect = 4e-54, Method: Composition-based stats. Identities = 64/231 (27%), Positives = 101/231 (43%), Gaps = 14/231 (6%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWE-EHRVEDVATPEGFDRDPELVQAFYNARRR 60 + V +TGAG+S SGI +R+ GL+ + E + + E F+ Sbjct: 10 QAKHVTFMTGAGVSTASGIPDYRSKGGLYADQVDPEYALSIDNLQAHHE---DFHKFVVN 66 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 + P +PN H +A + + G +VTQN+D L +AG +V+ HG L ++ C Sbjct: 67 NMYFPAAKPNVIHEKMATITNQKG---TIVTQNVDGLDRKAGAEHVVEFHGNLYRIYCQT 123 Query: 121 SGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGE--MPLGMDEIYMALSMADIFIAIGT 178 + D+ + + LRP +V +GE P + A+S AD+ I +GT Sbjct: 124 CHKHFDYETYLKSDVHAA---DGGILRPDIVLYGEPINPDTVSAAIEAISTADLLIVVGT 180 Query: 179 SGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFV 229 S VYP AG + A+ A V +N E + G A V + V Sbjct: 181 SFVVYPFAGLIGYAQPE-ATIVAVNREKIALPEGAHMV-QGDAVDVFAKLV 229 >UniRef50_D1Y076 Transcriptional regulator, Sir2 family n=1 Tax=Prevotella bivia JCVIHMP010 RepID=D1Y076_9BACT Length = 248 Score = 213 bits (543), Expect = 5e-54, Method: Composition-based stats. Identities = 85/234 (36%), Positives = 126/234 (53%), Gaps = 11/234 (4%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 + +++V TGAGIS ESG+ TFR DGLW+ + +ATPEGF D E V FYN R+ L Sbjct: 16 RQKIVVFTGAGISKESGMETFRDLDGLWKRYDPAQIATPEGFAADTEFVLNFYNEMRKML 75 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG 122 +I+PN AH +A L++ ++TQNID+LHERAG+++VIH+HGEL KV S Sbjct: 76 I--DIEPNHAHKIVAALEEW--HDVTVITQNIDDLHERAGSSHVIHVHGELTKVTSSYDY 131 Query: 123 QVLDWTGDVTPEDKCHCCQ---FPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTS 179 + + + LRP++VWFGE + + AD + IGTS Sbjct: 132 LNPRYIQPYPLDKAIKVGDKALDGSQLRPYIVWFGESLPDLGACVQRMQQADYLLIIGTS 191 Query: 180 GHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFA-EKYYGPASQVVPEFVEKL 232 V PAAG ++ A + +P+ + E PA++ + F+++L Sbjct: 192 LTVMPAAGLINYAPFNIPKFCI---DPNNLMLPSNIEHIKEPATRGIDIFIKRL 242 >UniRef50_A8PZF9 NAD-dependent deacetylase SIRT1, putative n=1 Tax=Brugia malayi RepID=A8PZF9_BRUMA Length = 584 Score = 213 bits (543), Expect = 5e-54, Method: Composition-based stats. Identities = 61/242 (25%), Positives = 97/242 (40%), Gaps = 23/242 (9%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVE--DVATPEG------FDRDPELVQAF 54 R+LVLTGAG+S GI FR+ +G++ VE D+ P F ++P+ F Sbjct: 130 CSRILVLTGAGVSVSCGIPDFRSRNGVYARLHVEYPDLPDPTAMFDINYFSKNPKPFFEF 189 Query: 55 YNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELL 114 R+L + + H + L+D+ G TQNID L + AG ++ HG Sbjct: 190 ----ARELFPGRYEASMCHYFIKALEDS-GKLLRNYTQNIDTLEQVAGIKRIVQCHGSFA 244 Query: 115 KVRCSQSGQVLDWTGDVTPEDK-----CHCCQFP-APLRPHVVWFGEMPLG--MDEIYMA 166 C G +D D C C P ++P +V+FGE +++ Sbjct: 245 TATCRNCGLKVDSEAIREDIDSGRVAMCRVCSHPEGVMKPDIVFFGEDLSDDFHEKMAED 304 Query: 167 LSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVP 226 M D+ + IG+S V P A + + +N E + G +V Sbjct: 305 REMVDLVVVIGSSLKVQPVALLPYNINPE-VPQILINRESLPH-YATDIELLGNCDDIVA 362 Query: 227 EF 228 + Sbjct: 363 QL 364 >UniRef50_Q5R1T8 NAD-dependent deacetylase sirtuin 2 homolog n=2 Tax=Coelomata RepID=Q5R1T8_BOMMO Length = 387 Score = 213 bits (542), Expect = 5e-54, Method: Composition-based stats. Identities = 53/263 (20%), Positives = 99/263 (37%), Gaps = 39/263 (14%) Query: 3 KPRVLVLTGAGISAESGIRTFRAA-DGLWEEHRVEDVATPEG------FDRDPELVQAFY 55 +++ L+GAGIS +GI FR+ GL+ + ++ P+ F ++P + F+ Sbjct: 87 CKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNP---KPFF 143 Query: 56 NARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGEL 113 ++L +P +H + L + G TQNID L AG ++ HG Sbjct: 144 TLA-KELFPGSFKPTISHYFIRLLHEK-GLLLRHYTQNIDTLERGAGIPEEKLVEAHGTF 201 Query: 114 LKVRCSQSGQVL--DWTGDVTPEDKCHCC-QFPAPLRPHVVWFGEMPLGMDE--IYMALS 168 C + ++ + D+ C + P ++P +V+FGE + + Sbjct: 202 YTSHCLDCRKEYPLEFVKERIFADQIPICTECPGVVKPDIVFFGESLPERFQMCLEEDFK 261 Query: 169 MADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQV------------------- 209 D+ I +G+S V P A + +N E + V Sbjct: 262 QCDMLIIMGSSLEVQPFASLIDMVPDSCPRL-LINREKAGVRPPILRIRGLMCGGLQLDE 320 Query: 210 GNEFAEKYYGPASQVVPEFVEKL 232 G+ G + + ++L Sbjct: 321 GSYRDVARLGDCDEGCQDLADRL 343 >UniRef50_B9L4G7 NAD-dependent deacetylase 1 (Regulatory protein SIR2homolog 1) n=2 Tax=Thermomicrobia (class) RepID=B9L4G7_THERP Length = 282 Score = 213 bits (542), Expect = 5e-54, Method: Composition-based stats. Identities = 72/217 (33%), Positives = 105/217 (48%), Gaps = 11/217 (5%) Query: 7 LVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQ-QP 65 + TGAGIS ESGI +R +GLW F DPE+ + +++ RR++ Sbjct: 41 MAFTGAGISTESGIPDYRGPNGLWSRENPTR---YRDFLNDPEVRRRYWDRRRQRYPILA 97 Query: 66 EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGN--TNVIHMHGELLKVRCSQSGQ 123 +PN H+ALA+LQ A G ++VTQNID LH++AG+ V+ +HG +RC Sbjct: 98 GARPNVGHVALARLQ-AAGYLEIIVTQNIDGLHQKAGSPPERVVELHGTAHAIRCLSCEL 156 Query: 124 VLDWTGDVT--PEDKCHCCQFPAPLRPHVVWFGE-MPLGMDEIYMALSMAD-IFIAIGTS 179 + P C ++ V FGE +P + E +AL+ A + + IGTS Sbjct: 157 LWPAEEFDPGPPGTIPDCPVCGGLVKEATVSFGEPVPRRILEHALALAEATPVMLVIGTS 216 Query: 180 GHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEK 216 V PAA A GA +N EP+ + E A Sbjct: 217 LKVVPAAHVPRRAARAGAFVAIVNDEPTPLDREAAVV 253 >UniRef50_A3LN35 NAD-dependent histone deacetylase SIR2 (Regulatory protein SIR2) (Silent information regulator 2) (Fragment) n=1 Tax=Pichia stipitis RepID=A3LN35_PICST Length = 391 Score = 213 bits (542), Expect = 5e-54, Method: Composition-based stats. Identities = 62/253 (24%), Positives = 97/253 (38%), Gaps = 30/253 (11%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPE------GFDRDPELVQAFYN 56 +++V++GAGIS GI FR+ GL+ + ++ P+ F +DP + FY+ Sbjct: 110 AKKIMVISGAGISTSLGIPDFRSFKGLYAQLEHLNLKDPQKVFDMGAFQKDPSI---FYS 166 Query: 57 ARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELL 114 L PE + + H + LQD G TQNIDNL R G +I HG Sbjct: 167 IAHLVL-PPEGRFSMLHSFIKLLQDK-GKLLRNYTQNIDNLESRVGIHPDKLIQCHGSFG 224 Query: 115 KVRCSQS-----GQVLDWTGDVTPEDKCHCCQ--------FPAPLRPHVVWFGE-MPLGM 160 C G + +C C ++P + +FGE +P Sbjct: 225 SASCLTCSNRFAGHKIFEHIRHQHVPRCSTCWKTIQEAVIIHGVIKPDITFFGEDLPKKF 284 Query: 161 DEIYM-ALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYG 219 + D+ I +GTS V P + + + V +N +P +F G Sbjct: 285 YRLLEPDCQTCDLVIVVGTSLKVEPVSSIIDKIPRS-VPRVLINKDPIP-DRDFDLSLIG 342 Query: 220 PASQVVPEFVEKL 232 VV +L Sbjct: 343 LCDDVVCHLTREL 355 >UniRef50_B3QYR0 Silent information regulator protein Sir2 n=1 Tax=Chloroherpeton thalassium ATCC 35110 RepID=B3QYR0_CHLT3 Length = 244 Score = 213 bits (542), Expect = 5e-54, Method: Composition-based stats. Identities = 90/243 (37%), Positives = 130/243 (53%), Gaps = 17/243 (6%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 K R+++ +GAG+SAES I TFR ++GLWE HR+EDVA+PEG+ R+P LV FY R ++ Sbjct: 2 KKRIVIFSGAGLSAESDIPTFRDSNGLWESHRIEDVASPEGWQRNPALVLDFYAKRYEKM 61 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG 122 Q +PN+AH A+AKL +L + +TQNIDNL E+AG V H+HG + +C Sbjct: 62 Q--TCKPNSAHEAIAKL--SLRHEVICITQNIDNLLEQAGVETVWHLHGRIDVQKCEWHK 117 Query: 123 QVLDWTGDVTPEDKC-----------HCCQFPAPLRPHVVWFGEMPLGMDE-IYMALSMA 170 + + + D C LRP VVWFGE + + Sbjct: 118 SIPAYYDERFQCDFSGAIKRPIAFGDACPVCGGQLRPDVVWFGEAVDMRQSYLQELVRTT 177 Query: 171 DIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVE 230 DIFI +GTS VYPAAG + + ++ +P+ E G AS+ +P V+ Sbjct: 178 DIFIGVGTSAQVYPAAGLLSIFEKVRDK-YFIDPKPAYSVLSDFEVLNGSASEKMPLLVD 236 Query: 231 KLL 233 +L+ Sbjct: 237 QLI 239 >UniRef50_Q5HU51 NAD-dependent deacetylase n=15 Tax=Campylobacter RepID=NPD_CAMJR Length = 233 Score = 212 bits (541), Expect = 7e-54, Method: Composition-based stats. Identities = 78/240 (32%), Positives = 132/240 (55%), Gaps = 10/240 (4%) Query: 4 PRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQ 63 +++L+GAG+SA SG++TFR DGLWEE+ V +V + GF ++P+ V FY+ARR QLQ Sbjct: 2 KNIMILSGAGLSAPSGLKTFRDNDGLWEEYDVMEVCSATGFRKNPKKVLDFYDARRVQLQ 61 Query: 64 QPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQ 123 ++PN AH +A+L++ G ++TQN+D+L ERAG +V+H+HG L ++RC + Sbjct: 62 --NVKPNHAHEKIAQLKEKWGKNLFVITQNVDDLLERAGCKDVVHLHGFLPELRCLKCEG 119 Query: 124 VLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGHVY 183 + + + + +C C+ LR ++V F E +Y L+ +FI+IGTSG V Sbjct: 120 IFNIGYEKIIDKQCPKCKSKD-LRHNIVMFEEQAPAYATLYSLLNQTSLFISIGTSGAVL 178 Query: 184 PAAGFVHEAKLHGAHTVELNLEP--SQVGNEFAEKYYGPASQVVPEFVEKLLKGLKAGSI 241 P + + LN+ + + F + Y + + + +K G++ Sbjct: 179 PVGRYASMCEKS-----ILNIYEKDANLERYFDKIYIEDIINAIDKIALDIENFMKDGNV 233 >UniRef50_C3YDA2 Putative uncharacterized protein n=1 Tax=Branchiostoma floridae RepID=C3YDA2_BRAFL Length = 323 Score = 211 bits (539), Expect = 1e-53, Method: Composition-based stats. Identities = 68/264 (25%), Positives = 110/264 (41%), Gaps = 41/264 (15%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATP---EGFDRDPELVQAFYNARR 59 R+LV+TGAG+S ESG+ +R+ + V P + F +D + Q N R Sbjct: 61 SKRLLVITGAGLSTESGLPDYRSVKSPPRAGKDRPVIGPVMYQDFVKDTHVRQG--NWAR 118 Query: 60 RQLQQPEI---QPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKV 116 + P +PN +H AL + + G LVTQN+D+LH +AG+ + +HG + Sbjct: 119 NYVGWPGFSSHRPNVSHRALVQWERQ-GKLHWLVTQNVDDLHRKAGSERMTELHGSAFRA 177 Query: 117 RCSQSGQVLDWTG-----------------DVTPE-------------DKCHCCQFPAPL 146 C V+ +G ++ P+ HC + PL Sbjct: 178 ACLSCKHVVPRSGLQQVISNMNPHWEAVPFEIRPDADVALTPEQIEGFRAPHCGKCGGPL 237 Query: 147 RPHVVWFGEMPLG--MDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNL 204 +P +V+FGE + ++ L +D + G+S VY A FV A LN+ Sbjct: 238 KPDMVYFGECVPKDTVQLVFEKLEESDSILVAGSSLQVYSAYRFVSAAHKQNKPVAILNI 297 Query: 205 EPSQVGNEFAEKYYGPASQVVPEF 228 P++ N A K V+ + Sbjct: 298 GPTRADNLAALKINSRCGDVLTKL 321 >UniRef50_C4M6Q0 Sir2 family transcriptional regulator, putative n=2 Tax=Entamoeba RepID=C4M6Q0_ENTHI Length = 359 Score = 211 bits (537), Expect = 2e-53, Method: Composition-based stats. Identities = 59/242 (24%), Positives = 99/242 (40%), Gaps = 20/242 (8%) Query: 4 PRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEG------FDRDPELVQAFYN 56 V+V+ GAGIS +GI FR GL++ ++ P F +P + FY Sbjct: 103 SNVVVMAGAGISTSAGIPDFRTPGTGLYDNLEAYNLPFPTAVFDINYFKSNP---KPFYT 159 Query: 57 ARRRQLQ-QPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGEL 113 + + P H L L + LG +L TQNID L ++G N ++ HG Sbjct: 160 IASELMPGLGKYFPTPTHYFLTYL-NKLGYISMLFTQNIDGLEIQSGFPNEKLVMAHGNY 218 Query: 114 LKVRCSQSGQVLD---WTGDVTPEDKCHCCQFPAPLRPHVVWFGE-MPLGMDEIYMALSM 169 C + + + +V C+C ++P +V+FGE +P + + Sbjct: 219 YSGHCLKCKKSFKQSYFIDNVRDGKVCYCDSCKGLVKPDIVFFGEGLPQQFFNNFEKVEE 278 Query: 170 ADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNL-EPSQVGNEFAEKYYGPASQVVPEF 228 D+ I +GTS V P A + K + V +N+ + + + G + + E Sbjct: 279 CDLLIVLGTSLLVQPFASLIDLTKKN-TPRVYINMKDFNSFNKINDLQIIGKCDESILEI 337 Query: 229 VE 230 E Sbjct: 338 AE 339 >UniRef50_Q9I7I7 Sirt2 n=8 Tax=Drosophila RepID=Q9I7I7_DROME Length = 355 Score = 211 bits (537), Expect = 2e-53, Method: Composition-based stats. Identities = 59/262 (22%), Positives = 93/262 (35%), Gaps = 39/262 (14%) Query: 4 PRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATP------EGFDRDPELVQAFYN 56 +++ + GAGIS +GI FR+ GL+ + ++ P + F+++P F+ Sbjct: 48 RKIVTMVGAGISTSAGIPDFRSPGSGLYSNLKKYELPHPTAIFDLDYFEKNPA---PFF- 103 Query: 57 ARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELL 114 A ++L P AH + L D G TQNID L G +I HG Sbjct: 104 ALAKELYPGSFIPTPAHYFIRLLNDK-GLLQRHYTQNIDTLDRLTGLPEDKIIEAHGSFH 162 Query: 115 KVRCSQSGQVL--DWTGDVTPEDKCHCCQ-FPAPLRPHVVWFGE-MPLGMDEI-YMALSM 169 C + + DW D+ CQ ++P +V+FGE +P Sbjct: 163 TNHCIKCRKEYDMDWMKAEIFADRLPKCQKCQGVVKPDIVFFGENLPKRFYSSPEEDFQD 222 Query: 170 ADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEP-------------------SQVG 210 D+ I +GTS V P A V +N + + Sbjct: 223 CDLLIIMGTSLEVQPFASLVWRPGPRCIRL-LINRDAVGQASCVLFMDPNTRSLLFDKPN 281 Query: 211 NEFAEKYYGPASQVVPEFVEKL 232 N + G V + L Sbjct: 282 NTRDVAFLGDCDAGVMALAKAL 303 >UniRef50_C5L8Y4 Chromatin regulatory protein sir2, putative n=2 Tax=Perkinsus marinus ATCC 50983 RepID=C5L8Y4_9ALVE Length = 719 Score = 211 bits (537), Expect = 2e-53, Method: Composition-based stats. Identities = 56/230 (24%), Positives = 90/230 (39%), Gaps = 29/230 (12%) Query: 4 PRVLVLTGAGISAESGIRTFRAAD-GLWEEH------RVEDVATPEGFDRDPELVQAFYN 56 R++V+ GAGIS +GI FR GL+ R ED+ + + F ++P FY+ Sbjct: 71 KRIIVMAGAGISVSAGIPDFRTPGSGLYYNLQSYKLGRPEDMFSMDFFKKNP---YPFYH 127 Query: 57 ARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELL 114 + + +P H + LQ+ G + TQNID L AG + N++ HG Sbjct: 128 FAKHLWPTGQHRPTPTHYFVRLLQEK-GLLHRMYTQNIDGLERLAGVKDENLVEAHGTFS 186 Query: 115 KVRCSQSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGE-MPLGMDEIYM-ALSMADI 172 C + V+D ++P +V+FGE +P + D+ Sbjct: 187 TASCIKCRSVVDPIQV-------------GLIKPDIVFFGESLPRRFHTLMQSDFETCDL 233 Query: 173 FIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPAS 222 I +GTS V P V + +N E + G + Sbjct: 234 LIVMGTSLKVAPFNRLVSDVPDTTVRL-LVNREKQPGAGSDPMVFDGDCA 282 >UniRef50_B3RYT4 Putative uncharacterized protein (Fragment) n=1 Tax=Trichoplax adhaerens RepID=B3RYT4_TRIAD Length = 382 Score = 210 bits (536), Expect = 3e-53, Method: Composition-based stats. Identities = 58/221 (26%), Positives = 90/221 (40%), Gaps = 22/221 (9%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPE------GFDRDPELVQAF 54 + ++V+ GAGIS +GI FR GL++ + D+ PE F +P F Sbjct: 45 KCKNIIVMAGAGISTSAGIPDFRTPGTGLYDNLQKYDLPDPESIFRLSYFRENPS---PF 101 Query: 55 YNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGN--TNVIHMHGE 112 Y+ ++L +P +H + L D G TQNID L A +I HG Sbjct: 102 YSLA-KELYPGRYKPTLSHYFIKLLHDK-GLLLRHFTQNIDTLEHLANVPKEKLIEAHGS 159 Query: 113 LLKVRCS--QSGQVL--DWTGDVTPEDKCHCC-QFPAPLRPHVVWFGE-MPLGMDEI-YM 165 C + DW + +D C +P++P +V+FGE +P + Sbjct: 160 FSAAHCINHDCQKEYSSDWVKERVLQDIIPLCSNCNSPVKPDIVFFGESLPTKFFVATHE 219 Query: 166 ALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEP 206 D+ I +GTS V P A + + +NLE Sbjct: 220 DFPQCDLLIIMGTSLKVQPFASLIERVPDA-TPRLLINLEK 259 >UniRef50_C5GPX3 SIR2 family histone deacetylase n=2 Tax=Ajellomyces dermatitidis RepID=C5GPX3_AJEDR Length = 341 Score = 210 bits (536), Expect = 3e-53, Method: Composition-based stats. Identities = 82/275 (29%), Positives = 116/275 (42%), Gaps = 46/275 (16%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 R+L L GAG+SA SGI T+ W H V + T F DP V FY+ RRR Sbjct: 62 SKRILTLLGAGLSAASGIGTYVDEGRFWRTHNVRRLCTYGAFREDPSRVWWFYSDRRR-- 119 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELLKVRCSQ 120 + +PN AH ALAKL LG+ L V QNID L RAG T+ +++HG+ ++CS Sbjct: 120 GAMKAEPNKAHYALAKLARKLGNGMLTVCQNIDRLCPRAGQPETSTVYLHGDYFTIKCSS 179 Query: 121 SGQVLDWTGDVTP-------------------------EDKCHCCQFPAPLRPHVVWFGE 155 D P E C + LRP V WFGE Sbjct: 180 ESCTYSRADDNDPIVPALTLPSTHSISDPDFPLPHVPEESLPRCPSCSSLLRPGVTWFGE 239 Query: 156 M--PLGMDEIYMALSM----------ADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELN 203 P ++ L D+ + IGT+ V+P V +A+ GA +N Sbjct: 240 TMPPAQTKRVHDWLQQIDRDPESNGHIDLVLVIGTAATVHPVLSLVTQARKKGAKVCVVN 299 Query: 204 LEPSQVG-----NEFAEKYYGPASQVVPEFVEKLL 233 + +E + G A +V+PE ++++ Sbjct: 300 PDRESAQKVGGMDEGNWWFRGGAEEVLPEIFKEVI 334 >UniRef50_C4WX51 ACYPI009170 protein n=1 Tax=Acyrthosiphon pisum RepID=C4WX51_ACYPI Length = 333 Score = 210 bits (536), Expect = 3e-53, Method: Composition-based stats. Identities = 66/265 (24%), Positives = 110/265 (41%), Gaps = 42/265 (15%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 E ++LVLTGAGIS ESGI +R+AD GL+ + V + F ++PE+ ++ R Sbjct: 71 EHKKILVLTGAGISTESGIPDYRSADVGLYARSKNRPVIY-QQFIKNPEVRIRYW--ARN 127 Query: 61 QLQQPEIQ---PNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVR 117 + P PN AH L L+D ++TQN+DNLH +AG+ NV+ +HG V Sbjct: 128 YVGWPRFSSMSPNYAHKFLKNLEDK-NKIVHIITQNVDNLHTKAGSKNVLELHGTAYVVH 186 Query: 118 CSQSGQVLDW--------------------------TGDVTPED-----KCHCCQFPA-P 145 C + +D ++ PE+ C + Sbjct: 187 CLKCDYTIDRHKFQDVLSSLNPQVSIKELYSVRPDGDVELPPEEIGGFKVPECPKCQGNL 246 Query: 146 LRPHVVWFGEMPL--GMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELN 203 L P +V+FG+ + + + D + +G+ VY V K +N Sbjct: 247 LIPRLVFFGDNLPKKRVQRVNDFVEECDSLLVMGSFLFVYSGYRIVLGTKFVNKPVAVVN 306 Query: 204 LEPSQVGNEFAEKYYGPASQVVPEF 228 + P++ + K +++P Sbjct: 307 IGPTRGDDWVDFKIEARFGEILPLL 331 >UniRef50_Q6BPH5 DEHA2E13596p n=4 Tax=Saccharomycetaceae RepID=Q6BPH5_DEBHA Length = 573 Score = 210 bits (535), Expect = 3e-53, Method: Composition-based stats. Identities = 66/265 (24%), Positives = 98/265 (36%), Gaps = 38/265 (14%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEH------RVEDVATPEGFDRDPELVQAFY 55 + ++LV+TGAGIS GI FR++ G + + ++V + F DP + FY Sbjct: 259 KAKKILVVTGAGISTSLGIPDFRSSKGFYSQLQYLGLSDPQEVFDLDFFHSDPNI---FY 315 Query: 56 NARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGEL 113 + L PE H + LQ+ G TQNIDNL G +I HG Sbjct: 316 SIAYMIL-PPEKSYTPLHAFIKLLQNK-GKLLRNYTQNIDNLESNVGIKPEKLIQCHGSF 373 Query: 114 LKVRCSQSGQVLDWTGDVTP---EDKCHCCQFP------------------APLRPHVVW 152 C + ++ +C + ++P + + Sbjct: 374 ATASCVTCKYQVKGEKIYPKIREKEVPYCPKCKNARKILLNKEDAYVPESYGVMKPDITF 433 Query: 153 FGE-MPLGMDE-IYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVG 210 FGE +P I L D+ I+IGTS V P A V H V +N +P Sbjct: 434 FGEPLPTRFHNMIRQDLMECDLLISIGTSLKVSPVADIVERIPEH-IPQVLINKDPIDHC 492 Query: 211 NEFAEKYYGPASQVVPEFVEKLLKG 235 N F G ++L KG Sbjct: 493 N-FDVSILGYCDDTANYLCKRLGKG 516 >UniRef50_Q6C219 YALI0F11583p n=1 Tax=Yarrowia lipolytica RepID=Q6C219_YARLI Length = 320 Score = 210 bits (535), Expect = 3e-53, Method: Composition-based stats. Identities = 68/251 (27%), Positives = 100/251 (39%), Gaps = 29/251 (11%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEH--------RVEDVATPEGFDRDPELVQAF 54 ++VL GAGIS GI FR+ADGL++ ++V E FD+DP F Sbjct: 60 AQNIVVLCGAGISTSLGIPDFRSADGLYKSLDLESLGLSDPQEVFDLEVFDQDPT---PF 116 Query: 55 YNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGE 112 Y + + + + H L LQD G + TQNID+L AG + ++ HG Sbjct: 117 YRVASKVMMPTQALISPTHAFLKLLQDK-GKLLRIYTQNIDDLEHIAGIEESKMVQCHGA 175 Query: 113 LLKVRCSQSGQVLDWTGDVT-----PEDKCHCCQFPAPLRPHVVWFGE-MPLGMDEIYMA 166 C Q G + C + ++P +V+FGE +P + + Sbjct: 176 FHMATCRQCGAKVTCESLRPEIVAGEIPMCRRKRCEGVIKPDIVFFGEALPDRFRHMVRS 235 Query: 167 -------LSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYG 219 D+F+ +GTS V PA + L G V +N EPS F G Sbjct: 236 DIIMGGPTPKVDLFLCLGTSLKVSPACDIAKQVPL-GVPRVYINREPS-ARFYFDISLCG 293 Query: 220 PASQVVPEFVE 230 + V E Sbjct: 294 ESDLAVQAICE 304 >UniRef50_D2S8Y6 Silent information regulator protein Sir2 n=1 Tax=Geodermatophilus obscurus DSM 43160 RepID=D2S8Y6_9ACTO Length = 297 Score = 210 bits (535), Expect = 4e-53, Method: Composition-based stats. Identities = 75/265 (28%), Positives = 113/265 (42%), Gaps = 42/265 (15%) Query: 4 PRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQ 63 +VL+GAG+S +SGI +R A G H T + F RDP ++ R + Sbjct: 37 GNTVVLSGAGLSTDSGIPDYRGATGSLRRHTPM---TYQTFLRDPRGRHRYW--ARSFVG 91 Query: 64 QP---EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 P E +PNA H A+A LQ A G ++TQN+D LH+ AG +V+ +HG L + C Sbjct: 92 WPQIREARPNAGHAAVADLQRA-GLVGGVITQNVDGLHQAAGARDVLELHGGLDRTVCLA 150 Query: 121 SGQVLDW-----------------------TGDVTPEDK-------CHCCQFP-APLRPH 149 G V D GD D+ C PL+P Sbjct: 151 CGDVADRGQLHERLRAVNPHFGPHVDEVNPDGDAELPDELLDGFVMVDCAACGRGPLKPD 210 Query: 150 VVWFGEMPLG--MDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPS 207 VV+FGE +D + + A + +G+S V FV A+ G +NL P+ Sbjct: 211 VVFFGETVPRDRVDTCFAMVEQAGSLLVLGSSLTVMSGYRFVLRAEKLGIPVGLVNLGPT 270 Query: 208 QVGNEFAEKYYGPASQVVPEFVEKL 232 + + + P V+P+ V ++ Sbjct: 271 RGDAKVDVRVDAPLGTVLPDLVRRV 295 >UniRef50_C4XZ95 Putative uncharacterized protein n=1 Tax=Clavispora lusitaniae ATCC 42720 RepID=C4XZ95_CLAL4 Length = 522 Score = 210 bits (535), Expect = 4e-53, Method: Composition-based stats. Identities = 67/261 (25%), Positives = 98/261 (37%), Gaps = 38/261 (14%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEH------RVEDVATPEGFDRDPELVQAFYN 56 ++LV+TGAGIS GI FR++ G + ++V + F DP + FY+ Sbjct: 204 AKKILVITGAGISTSLGIPDFRSSKGFYSRLSNLGLSDPQEVFDLDIFRTDPSI---FYS 260 Query: 57 ARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELL 114 L P+ H + LQD TQNIDNL AG +I HG Sbjct: 261 IAYMIL-PPDNVYAPLHRFIKLLQDK-NKLLRNYTQNIDNLEANAGISQDKMIQCHGSFA 318 Query: 115 KVRCSQSGQVLDWTGDVTPE-----DKCHCC----------------QFPAPLRPHVVWF 153 C G + C C + ++P++ +F Sbjct: 319 FSTCVTCGYQVPGETLYPLMRKKEIPYCPMCAKKRKKLMDNDDTYIEESYGVMKPNITFF 378 Query: 154 GEMPLGM--DEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGN 211 GE + D I L+ D+ I+IGTS V P A V + + + +N +P Q N Sbjct: 379 GEALPRVFHDNINRDLADCDLVISIGTSLKVAPVADIVDKVRPE-VPQILINKDPIQHCN 437 Query: 212 EFAEKYYGPASQVVPEFVEKL 232 F G VV +L Sbjct: 438 -FDVSLLGYCDDVVSYLCHRL 457 >UniRef50_C1BNZ8 NAD-dependent deacetylase sirtuin-2 n=3 Tax=Caligidae RepID=C1BNZ8_9MAXI Length = 357 Score = 210 bits (535), Expect = 4e-53, Method: Composition-based stats. Identities = 58/239 (24%), Positives = 97/239 (40%), Gaps = 25/239 (10%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAAD-GLWEEH--------RVEDVATPEGFDRDPELVQ 52 + +++ + GAGIS +GI FR D GL+ D+ + F +P + Sbjct: 80 KARKIITMVGAGISTSAGIPDFRTPDSGLYARIAEEYPDVGNPTDLFSMNYFRMNP---K 136 Query: 53 AFYNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMH 110 F+ + L+ +P H + L+ G TQNID L +AG + ++ H Sbjct: 137 PFFKLAKDLLKSQSFRPTPCHYFIKLLESK-GLLLRHYTQNIDTLERKAGVNSDLLVEAH 195 Query: 111 GELLKVRCSQSGQVLD--WTGDVTPEDK---CHCCQFPAPLRPHVVWFGE-MPLGMD-EI 163 G C G D W E C ++P +V+FGE +P + Sbjct: 196 GSFASSTCLSCGLRYDQAWMEKKVHEMDVVTCERPDCHGIVKPDIVFFGESLPERFSGLV 255 Query: 164 YMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEP--SQVGNEFAEKYYGP 220 + D+ I +GTS V P A V++ + +N+E ++ GN+F + G Sbjct: 256 FQDFPFCDLLIIMGTSLQVQPFASLVNQVPET-TPRLLINMEVVGNEGGNDFILRLMGR 313 >UniRef50_A7RLD5 Predicted protein (Fragment) n=1 Tax=Nematostella vectensis RepID=A7RLD5_NEMVE Length = 335 Score = 210 bits (535), Expect = 4e-53, Method: Composition-based stats. Identities = 60/212 (28%), Positives = 86/212 (40%), Gaps = 21/212 (9%) Query: 9 LTGAGISAESGIRTFRAAD-GLWEEHRVEDVATP------EGFDRDPELVQAFYNARRRQ 61 + GAGIS SGI FR GL++ + ++ P E F DP + F+ + Sbjct: 1 MAGAGISTPSGIPDFRTPGTGLYDNLQEYNIPEPTAIFDIEYFWYDP---RPFFCLA-KT 56 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELLKVRCS 119 L QPN H + L D G + TQNID L AG ++ HG C Sbjct: 57 LYPGNYQPNYVHYFVKLLHDK-GFLLRMYTQNIDGLERLAGLPAEKLVEAHGTFSTASCI 115 Query: 120 QSGQVLDW-----TGDVTPEDKCHCCQFPAPLRPHVVWFGE-MPLGMDEIYMALSMADIF 173 D T + +C + ++P VV+FGE +P + D+ Sbjct: 116 SCHHSYDGEQIRKTIENGDIPRCETIKCKGVIKPDVVFFGEDLPKRFYSFEIDFRKCDLL 175 Query: 174 IAIGTSGHVYPAAGFVHEAKLHGAHTVELNLE 205 + +GTS V P AG V+E V +N E Sbjct: 176 LVMGTSLEVEPFAGIVNEVSRS-TPRVLINRE 206 >UniRef50_C4DIV4 NAD-dependent protein deacetylase, SIR2 family n=1 Tax=Stackebrandtia nassauensis DSM 44728 RepID=C4DIV4_9ACTO Length = 248 Score = 209 bits (534), Expect = 5e-53, Method: Composition-based stats. Identities = 81/235 (34%), Positives = 110/235 (46%), Gaps = 7/235 (2%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 E RV+VLTGAGIS SG+ T+R DG W + A + D V + Sbjct: 14 EYSRVVVLTGAGISRPSGLPTYRGDDGTWNDPEAARAAEADTVGTDLAAVWRLWGG--LA 71 Query: 62 LQQPEIQPNAAHLALAKLQDALGDR---FLLVTQNIDNLHERAGNTNVIHMHGELLKVRC 118 QPN AH ALA +++L R L+VTQN+D LH+R G +VI +HG + RC Sbjct: 72 HLAAAAQPNPAHRALAGAEESLLARTASLLVVTQNVDGLHQRGGQRDVIELHGNAHRQRC 131 Query: 119 SQSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEM--PLGMDEIYMALSMADIFIAI 176 +G L T E C RP +V FGE ++ + + AD+ +A+ Sbjct: 132 LDAGCALVAPYVGTGETIPSCAGCGGRARPDIVLFGEQLDLEDLERAWNTAAEADLLLAV 191 Query: 177 GTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEK 231 GTS V PAA V A+ GA V L EP F G A + +P +V + Sbjct: 192 GTSCGVSPAANLVAVARQAGALCVALTREPLPFNPGFHAAVTGLAERELPRWVAE 246 >UniRef50_Q9USN7 NAD-dependent deacetylase hst2 n=1 Tax=Schizosaccharomyces pombe RepID=HST2_SCHPO Length = 332 Score = 209 bits (534), Expect = 5e-53, Method: Composition-based stats. Identities = 56/245 (22%), Positives = 99/245 (40%), Gaps = 22/245 (8%) Query: 4 PRVLVLTGAGISAESGIRTFRAA-DGLWEEHRVEDVATPEG------FDRDPELVQAFYN 56 ++ V+ GAGIS +GI FR+ G++ + ++ E F ++P + FY Sbjct: 28 KKICVMVGAGISTAAGIPDFRSPETGIYNNLQRFNLPYAEAVFDLSYFRKNP---RPFYE 84 Query: 57 ARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTN--VIHMHGELL 114 +L + +P H + L D TQNID L AG + +I HG Sbjct: 85 LAH-ELMPEKYRPTYTHYFIRLLHDKR-LLQKCYTQNIDTLERLAGVPDKALIEAHGSFQ 142 Query: 115 KVRCSQSGQVL--DWTGDVTPEDKCHCCQ-FPAPLRPHVVWFGE-MPLGMDE-IYMALSM 169 RC + ++ ++ + + C ++P +V++GE +P+ E + + Sbjct: 143 YSRCIECYEMAETEYVRACIMQKQVPKCNSCKGLIKPMIVFYGEGLPMRFFEHMEKDTKV 202 Query: 170 ADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQ--VGNEFAEKYYGPASQVVPE 227 D+ + IGTS V+P A + V +N EP+ + G V Sbjct: 203 CDMALVIGTSLLVHPFADLPEIVP-NKCQRVLINREPAGDFGERKKDIMILGDCDSQVRA 261 Query: 228 FVEKL 232 + L Sbjct: 262 LCKLL 266 >UniRef50_D0LVG3 Silent information regulator protein Sir2 n=1 Tax=Haliangium ochraceum DSM 14365 RepID=D0LVG3_HALO1 Length = 295 Score = 209 bits (533), Expect = 6e-53, Method: Composition-based stats. Identities = 89/268 (33%), Positives = 121/268 (45%), Gaps = 44/268 (16%) Query: 7 LVLTGAGISAESGIRTFRAADGLWEE----HRVEDVATPEGFDRDPELVQAFYNARRRQL 62 LVLTGAGISAESGI TFR DG W + +++AT F+R P+ V +Y RR Sbjct: 28 LVLTGAGISAESGIPTFRGKDGYWTVGSTVYHPQELATNAAFERLPDEVWQWYLYRRSVC 87 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTN--VIHMHGELLKVRC-- 118 + QPN AH AL L+ LGD FLL+TQN+D LH RAG + +HG++ +RC Sbjct: 88 R--RAQPNPAHDALVTLEQHLGDAFLLITQNVDGLHPRAGQSRARTYSVHGDIDLMRCAA 145 Query: 119 --------------SQSGQVLDWTG-----------DVTPEDKCHCCQFPAPLRPHVVWF 153 SGQ +G D C + RPHV+WF Sbjct: 146 GCSAELLPVPDQAWPVSGQAWPVSGQVGEIDAGQPLDEAQRQLLRCPRCGGRTRPHVLWF 205 Query: 154 GEMPL----GMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNL----- 204 E A + A + + +GTS V A+ HGA +++NL Sbjct: 206 DEYYDEAYFRFHSSRDAATRAALLLIVGTSASTNLPWQVVTLAQQHGATIIDINLESNPF 265 Query: 205 EPSQVGNEFAEKYYGPASQVVPEFVEKL 232 EP+ + + PA+ V+P V L Sbjct: 266 EPAALASPGGAVIRQPATAVLPPLVAAL 293 >UniRef50_B9GC62 Putative uncharacterized protein n=1 Tax=Oryza sativa Japonica Group RepID=B9GC62_ORYSJ Length = 446 Score = 209 bits (532), Expect = 9e-53, Method: Composition-based stats. Identities = 60/278 (21%), Positives = 103/278 (37%), Gaps = 53/278 (19%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFY-NARRR 60 + +++VLTGAG+S ESGI +R+ +G + T + F R + ++ + Sbjct: 110 QSKKLMVLTGAGMSTESGIPDYRSPNGAYSSG--FKPLTHQEFVRSIRARRRYWARSYAG 167 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 + QPN+AH ALA L+ +G +VTQN+D LH RAG+ V +HG + +V C Sbjct: 168 WRRFRRAQPNSAHYALASLER-IGRVHSMVTQNVDRLHHRAGSKPV-ELHGSVYEVACLD 225 Query: 121 SGQVLDWTGDVTPE---------------------------------------------- 134 G +D Sbjct: 226 CGTSIDRESFQEQVKDLNPKWALAIDSLEVGQPGSDKSFGMQQRPDGDIEIDEKFWEQDF 285 Query: 135 DKCHCCQFPAPLRPHVVWFGEMPLGM--DEIYMALSMADIFIAIGTSGHVYPAAGFVHEA 192 D C Q L+P VV FG+ + A D + +G++ A A Sbjct: 286 DIPSCNQCGGVLKPDVVMFGDNVPEERAESTKEAARNCDALLVVGSALMTMSAFRLARLA 345 Query: 193 KLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVE 230 A + + ++ + + K +++P ++ Sbjct: 346 HEANAPIAAITIGETRADSILSLKINARCGEILPRILQ 383 >UniRef50_A7SK95 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7SK95_NEMVE Length = 323 Score = 208 bits (531), Expect = 1e-52, Method: Composition-based stats. Identities = 79/263 (30%), Positives = 116/263 (44%), Gaps = 40/263 (15%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 E P++ V+TGAGIS ESGIR +R+ GL+ + + F + + Q ++ R Sbjct: 59 ENPKIFVITGAGISTESGIRDYRSEGKGLYAITNDRPMEY-QVFLKSAVMRQRYW--ARN 115 Query: 61 QLQQPEI---QPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVR 117 + PE QPN AH ALAKL+ LG LVTQN+D LH +AG+ NVI +HG +V Sbjct: 116 YVGWPEFGSRQPNEAHYALAKLE-TLGSVHSLVTQNVDALHTKAGSKNVIELHGCSHRVI 174 Query: 118 CSQSGQVL--------------DW----------------TGDVTPEDKCHCCQFPAPLR 147 C Q+ DW + V C L+ Sbjct: 175 CLGCNQITARTALQKRMIEFNPDWHAVGQGQAPDGDTFLTSEAVKDFKVPPCKACGGILK 234 Query: 148 PHVVWFGEMPLG--MDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLE 205 P VV+FG+ ++ Y L+ +D IG++ VY + F EA G LN+ Sbjct: 235 PEVVFFGDSVPKQIVNIAYDRLAESDALWIIGSTVEVYSSYRFATEASKQGKPIAILNIG 294 Query: 206 PSQVGNEFAEKYYGPASQVVPEF 228 ++ + K G V+P+ Sbjct: 295 KTRADKLASLKVSGVCGTVLPKL 317 >UniRef50_Q298C7 GA18650 n=3 Tax=Drosophila RepID=Q298C7_DROPS Length = 381 Score = 208 bits (530), Expect = 1e-52, Method: Composition-based stats. Identities = 61/265 (23%), Positives = 98/265 (36%), Gaps = 44/265 (16%) Query: 4 PRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEG------FDRDPELVQAFYN 56 +++ + GAGIS +GI FR+ GL++ + P F + P F+ Sbjct: 76 KKIITMVGAGISTSAGIPDFRSPGSGLYDNLAKYKLPYPTAIFELGYFKKKPA---PFF- 131 Query: 57 ARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELL 114 A ++L +P AH + L + G TQNID L AG + +I HG Sbjct: 132 ALAKELYPGSFEPTTAHYFIRLLHEK-GLLLRHYTQNIDTLDRLAGIPDEKLIEAHGSFH 190 Query: 115 KVRCSQSGQVLD--WTGDVTPEDKCHCC-QFPAPLRPHVVWFGE-MPLGMDEIYM-ALSM 169 C + D W D+ C ++P +V+FGE +P Sbjct: 191 TNHCIGCKKEYDMAWMKKEIFSDRLPTCTSCKKIVKPDIVFFGENLPEKFHNSLDGDFKE 250 Query: 170 ADIFIAIGTSGHVYPAAGFVHEAKLHGAHTV--ELNLEP-------SQVG---------- 210 D+ I +GT+ V+P A A+L G V +N + + + Sbjct: 251 CDLLIIMGTTLEVHPFASL---AQLPGPRCVRLLINRDAVGRPKYTTWMDGHNDDFLLYN 307 Query: 211 ---NEFAEKYYGPASQVVPEFVEKL 232 N + G + V E + L Sbjct: 308 RPNNTRDVAFLGDCDEGVLELAKNL 332 >UniRef50_C3XIH7 NAD-dependent deacetylase n=4 Tax=Campylobacterales RepID=C3XIH7_9HELI Length = 236 Score = 208 bits (530), Expect = 1e-52, Method: Composition-based stats. Identities = 89/241 (36%), Positives = 126/241 (52%), Gaps = 13/241 (5%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 M+ RV++ +GAG+SAESG+RTFR DGLWEE + +V + GF +D + V FY+ RR Sbjct: 1 MDSKRVMIFSGAGLSAESGLRTFRDNDGLWEEFDIMEVCSASGFAKDRKKVLDFYDKRRI 60 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 QL E+ PNAAH +A+L+ +++TQN+D+L ERAG NVIH+HG L +VRC Sbjct: 61 QL--GEVNPNAAHKMIARLKANYPQEVVVITQNVDDLLERAGCKNVIHLHGFLPEVRCEL 118 Query: 121 SGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALS-----MADIFIA 175 + + P+ C C + LR ++V F E + L +F+ Sbjct: 119 CETITNIGYQAMPKLICESCGEES-LRHNIVMFSEYAPNYALLARELERLSESENSLFVC 177 Query: 176 IGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKG 235 IGTSG V A F AK +V NLE S F + A P+ E+L+ Sbjct: 178 IGTSGEVLNVAQFSQCAK----KSVLNNLESSWFDECFNMCFIESAVSAAPKI-ERLVGE 232 Query: 236 L 236 Sbjct: 233 F 233 >UniRef50_A8NIK3 Putative uncharacterized protein n=1 Tax=Coprinopsis cinerea okayama7#130 RepID=A8NIK3_COPC7 Length = 313 Score = 207 bits (528), Expect = 2e-52, Method: Composition-based stats. Identities = 82/290 (28%), Positives = 119/290 (41%), Gaps = 68/290 (23%) Query: 3 KPRVLVLTGAGISAESGIRTFR-AADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 +V +L GAG+SA SGI T+R D +W+ + +AT EGF++DP F++ R+ Sbjct: 17 SKQVAILAGAGLSAGSGIPTYRGGPDAIWKNMDHDKLATVEGFEKDPVTCWQFHHMMRQL 76 Query: 62 LQQPEIQPNAAHLALAKL------------QDALGDRFLLVTQNIDNLHER--------- 100 + PNAAH ALA L L +TQN+D+L R Sbjct: 77 CL--DATPNAAHRALASLVVPSVRAKVLPGLKDPDSPPLFITQNMDSLSPRTLDEFKDKI 134 Query: 101 -AGN-----TNVIHMHGELLKVRCSQSGQVLDWTGDV----------------------- 131 +G ++ MHG + + +C Q V T Sbjct: 135 SSGEMEKAKERLVEMHGNIFRQKCLQCKHVSTSTDSHLAPGRYPKDANSPATARLEGTNP 194 Query: 132 ----TPEDKCHCCQ-----------FPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAI 176 + +D C PLRP VVWFGE+P G+ +I LS D+ I + Sbjct: 195 SATVSKDDLPRCGGPSWNGSNRYGRCGGPLRPSVVWFGEIPEGLGDIARHLSWTDMLIVV 254 Query: 177 GTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVP 226 GTS V+PAAGF+ K G N + S + + G +V+P Sbjct: 255 GTSCLVHPAAGFLKTVKDRGGKVAIFNYDASPKDDLADFLFLGKCEEVLP 304 >UniRef50_B7U9B0 Sirtuin 3 n=7 Tax=Chordata RepID=B7U9B0_PIG Length = 257 Score = 207 bits (528), Expect = 3e-52, Method: Composition-based stats. Identities = 63/241 (26%), Positives = 95/241 (39%), Gaps = 23/241 (9%) Query: 9 LTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEG------FDRDPELVQAFYNARRRQ 61 + GAGIS SGI FR+ G + + D+ PE F +P+ F ++ Sbjct: 1 MVGAGISTPSGIPDFRSPGTGYYSTLQSYDLPYPEAIFELSFFFHNPKPFFTF----AKE 56 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELLKVRCS 119 L +PN AH L L D G L TQNID L +G + ++ HG C+ Sbjct: 57 LYPGNYRPNTAHYFLRLLHDK-GLLLRLYTQNIDGLERASGIPASKLVEAHGSFASATCT 115 Query: 120 QSGQVL---DWTGDVTPEDKCHCCQFPAPLRPHVVWFGE-MPLGMDEIYMALSMADIFIA 175 + D+ DV + C ++P +V+FGE +P +AD+ + Sbjct: 116 VCRRPFPGEDFWADVMVDSVPRCRVCAGVVKPDIVFFGEPLPPRFLLHLADFPVADLLLI 175 Query: 176 IGTSGHVYPAAGFVHEAKLHGAHTVELNLE----PSQVGNEFAEKYYGPASQVVPEFVEK 231 +GTS V P A EA + +N + ++ G V VE Sbjct: 176 LGTSLEVEPFASL-SEAVRSSVPRLLINRDLVGTLARHPRGRDVVQLGDLVHGVKRLVEL 234 Query: 232 L 232 L Sbjct: 235 L 235 >UniRef50_UPI00006CA40C transcriptional regulator, Sir2 family protein n=1 Tax=Tetrahymena thermophila RepID=UPI00006CA40C Length = 471 Score = 207 bits (527), Expect = 3e-52, Method: Composition-based stats. Identities = 60/242 (24%), Positives = 101/242 (41%), Gaps = 20/242 (8%) Query: 5 RVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEG------FDRDPELVQAFYNA 57 R++ LTGAGIS +GI FR GL+ + + + PE F P Q FY Sbjct: 213 RIVFLTGAGISVSAGIPDFRTPGSGLYSQLQKYKLPYPEAIFEINYFKHHP---QPFYTL 269 Query: 58 RRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELLK 115 ++ ++H +A+ + +QNID L AG + ++ HG Sbjct: 270 C-KEFSSCGSHFTSSHFFIAETNRR-NRLLINFSQNIDGLELEAGLPESKLVQAHGHFRT 327 Query: 116 VRCSQSGQVLD---WTGDVTPEDKCHCCQFP-APLRPHVVWFGE-MPLGMDEIYMALSMA 170 +C +V D + V + C+C + ++P +V+FGE +P + +L+ A Sbjct: 328 AKCVNCKKVADIELFNEAVKNDKICYCKECEEGIVKPDIVFFGESLPQSFFQQIDSLNKA 387 Query: 171 DIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVE 230 D+ +GTS V+P A V K V +N E + G V + ++ Sbjct: 388 DLVFVMGTSLKVFPFAALVDLFKED-VPIVLINRENPGIKRRRFLFLEGEIDDNVEKIMK 446 Query: 231 KL 232 + Sbjct: 447 DI 448 >UniRef50_C5LN96 Neurofilament triplet L protein, putative n=5 Tax=Perkinsus marinus ATCC 50983 RepID=C5LN96_9ALVE Length = 656 Score = 207 bits (527), Expect = 3e-52, Method: Composition-based stats. Identities = 72/256 (28%), Positives = 99/256 (38%), Gaps = 29/256 (11%) Query: 4 PRVLVLTGAGISAESGIRTFRAAD-GLWEEHR--------VEDVATPEGFDRDPELVQAF 54 RV+VL GAGIS +GI FR+ + G++ + ED+ + F DP F Sbjct: 398 KRVVVLAGAGISVSAGIPDFRSPNTGIYANVKQYTNSLRAPEDLFSIHYFRHDP---YPF 454 Query: 55 YNARRR-QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTN--VIHMHG 111 Y QL + +P AAH +A L + G TQNID+L AG V+ HG Sbjct: 455 YRLCHEAQLGRGAHEPTAAHRFIAWLAEK-GALLRCYTQNIDSLEIDAGVPEELVVQAHG 513 Query: 112 ELLKVRCSQSGQVL--DWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMAL 167 L RC G D ++ E HC ++P VV+FGE D + L Sbjct: 514 HLRSARCIDCGCPYGGDMRDLLSSEKPVHCAACYGLVKPDVVFFGENLPERFFDCVQEDL 573 Query: 168 SMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQ--------VGNEFAEKYYG 219 S A + + +GTS V P + +NL P N Sbjct: 574 SQATLLVVMGTSLQVGPCNQIPILLPRT-TPRLLVNLTPPPHGMFRFGRADNYRDVFVEK 632 Query: 220 PASQVVPEFVEKLLKG 235 E +KL K Sbjct: 633 DTDSASEELRKKLEKA 648 >UniRef50_B3L8U3 Transcriptional regulatory protein sir2 homologue, putative n=6 Tax=Plasmodium RepID=B3L8U3_PLAKH Length = 301 Score = 207 bits (527), Expect = 3e-52, Method: Composition-based stats. Identities = 64/224 (28%), Positives = 105/224 (46%), Gaps = 13/224 (5%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADG-LWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 E V+ LTG+G SAES I +FR + +W ++ + T GF + PE + R Sbjct: 27 ECTYVVALTGSGTSAESNIPSFRGDNSSIWSKYDPKIYGTIWGFWKSPEKIWE---VIRD 83 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 EI+ N H AL+ L+ +LG ++TQNID LHE +GN+ VI +HG + + RC Sbjct: 84 ISSDYEIELNPGHTALSTLE-SLGYLKAVITQNIDGLHEESGNSKVIPLHGSVFEARCCT 142 Query: 121 SGQVLDWTGDVTPEDK------CHCCQFPAPLRPHVVWFGE-MPLG-MDEIYMALSMADI 172 + + + + C +P+VV FGE +P + + + D+ Sbjct: 143 CRETIQLNKIMLQKTSHFMHQLPPECPCGGIFKPNVVLFGEVIPKSLLKQAQKEIENCDL 202 Query: 173 FIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEK 216 + +GTS V A + A VE+N+ + + N ++ Sbjct: 203 LLVVGTSSSVSTATNLCYYAHRKKKKIVEVNISKTYITNRLSDC 246 >UniRef50_A4S2L7 Predicted protein n=2 Tax=Ostreococcus RepID=A4S2L7_OSTLU Length = 329 Score = 206 bits (526), Expect = 4e-52, Method: Composition-based stats. Identities = 67/267 (25%), Positives = 95/267 (35%), Gaps = 44/267 (16%) Query: 4 PRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEG------FDRDPELVQAFYNA 57 V+V+TGAGIS +GI FR+ GL+ D+ P+ F PE AFY Sbjct: 43 KNVVVMTGAGISVSAGIPDFRSERGLYARLGEYDLPYPQAIFELGYFREKPE---AFYKL 99 Query: 58 RRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELLK 115 + L P H + L D G TQNID+L G V+ HG Sbjct: 100 AKD-LYPGLYAPTPTHYFIKLLHDR-GLLRRCFTQNIDSLECATGLPKDKVVAAHGNFDS 157 Query: 116 VRCS--QSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGE-MPLGMDE-IYMALSMAD 171 +C + + C + ++P +V+FGE +P E + D Sbjct: 158 AKCLNGHDANIYEVERACRAGTPMTCAKCGEFVKPDIVFFGENLPRRFFECAQKDFEVCD 217 Query: 172 IFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEP------------------------- 206 + I IGTS V+P AG + K H + +NLE Sbjct: 218 LLIVIGTSLVVHPFAGLIERPKEH-VPRLLINLERCGEAQNTRVTKLYRMAGLGRGTGFD 276 Query: 207 -SQVGNEFAEKYYGPASQVVPEFVEKL 232 + N + G V E L Sbjct: 277 FDEATNYRDALFLGQCDDGVAELCSML 303 >UniRef50_C1DBX3 NAD-dependent deacetylase n=1 Tax=Laribacter hongkongensis HLHK9 RepID=NPD_LARHH Length = 248 Score = 206 bits (526), Expect = 4e-52, Method: Composition-based stats. Identities = 73/232 (31%), Positives = 106/232 (45%), Gaps = 5/232 (2%) Query: 3 KPRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 +LVLTGAG+S ESGI R+A G + D + F +DP + + Sbjct: 15 CRHLLVLTGAGLSTESGIPDVRSATTGQVRQPGCADALSLRFFQQDPAAFWSAFRTLFPF 74 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 P+ H LA+L A +VTQNID LH+RAG+ +VI HG + ++ C Sbjct: 75 GTTGSACPDIGHRLLAQLA-ATDKTVTVVTQNIDGLHQRAGSPHVIEAHGSVERLVCPAC 133 Query: 122 -GQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSG 180 + D T V P CHCC L+P VV GE MD AL+ AD +G+S Sbjct: 134 LCRDHDATCQVQPVPHCHCC--GEVLKPDVVLHGEPVEAMDAALAALAEADCLWVMGSSL 191 Query: 181 HVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 P A+ + +NL+P+ + + F + P +V +F + L Sbjct: 192 EAGPVNQLPALARHWRMPSALVNLQPTALDSRFDLCLHWPIGEVCAKFRQIL 243 >UniRef50_Q1YSP9 NAD-dependent deacetylase n=1 Tax=gamma proteobacterium HTCC2207 RepID=Q1YSP9_9GAMM Length = 270 Score = 206 bits (525), Expect = 5e-52, Method: Composition-based stats. Identities = 70/263 (26%), Positives = 104/263 (39%), Gaps = 41/263 (15%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 K R LVLTGAG+SAESG+ T+R G W+ T + F + + Q F+ R + Sbjct: 11 KARWLVLTGAGVSAESGVPTYRNQRGEWQRKPP---VTHQEFTGNHQARQRFW--ARNLV 65 Query: 63 QQ---PEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCS 119 +PN AH ALA L+ A G LVTQN+D LH+RAG+ VI +HG + V C Sbjct: 66 GWRFMSSARPNGAHSALASLEKA-GAVSCLVTQNVDGLHQRAGSQKVIDLHGRVDSVSCL 124 Query: 120 QSGQVLDWTG------------------------------DVTPEDKCHCCQFPAPLRPH 149 L D + C L+P Sbjct: 125 SCKLRLPRAPLQTWLEANNPDFAKLAGAIAPDGDADVDNLDHSSMQVPDCENCGGVLKPD 184 Query: 150 VVWFGEMPLG--MDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPS 207 V+FG+ + + + AD + +G+S + F A G V +N + Sbjct: 185 AVFFGDSVPAQRVADAEQQMKDADGLVVVGSSLVAFSGYRFCLWASKQGKPIVIINDGKT 244 Query: 208 QVGNEFAEKYYGPASQVVPEFVE 230 + K G V+ +++ Sbjct: 245 RGDELATAKVAGLCGDVLQGWLQ 267 >UniRef50_A5DNV7 Putative uncharacterized protein n=2 Tax=Pichia guilliermondii RepID=A5DNV7_PICGU Length = 403 Score = 206 bits (524), Expect = 7e-52, Method: Composition-based stats. Identities = 62/258 (24%), Positives = 99/258 (38%), Gaps = 32/258 (12%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEH------RVEDVATPEGFDRDPELVQAFY 55 + ++LV+TGAGIS GI FR+ G++ + + V + F +DP L FY Sbjct: 115 KAKKILVVTGAGISTSLGIPDFRSFQGIYSQLSRSGLENAQQVFHIDRFCKDPTL---FY 171 Query: 56 NARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGEL 113 + + L Q + + + H L L+ + TQNIDNL AG + ++H HG L Sbjct: 172 SVAHKILPQGD-KVSDFHRFLRLLEQK-NKLLRVYTQNIDNLELAAGIDPSRIVHCHGTL 229 Query: 114 LKVRCSQSGQVLDWTG-----DVTPEDKCHCC-------QFPAPLRPHVVWFGEMPLGMD 161 C + C C ++P + +FGE Sbjct: 230 STSTCLTCRATFSGAATFAAIKMRQVPYCSLCVTDLGSVPMKGLIKPDITFFGEDLSSRF 289 Query: 162 E--IYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYG 219 E I + D+ + GTS V P A V A V +N + + F + G Sbjct: 290 ETMIGKDVEECDLLLVAGTSLKVEPVASIVRNA--QNVKKVLVNRDK---IDGFDINFLG 344 Query: 220 PASQVVPEFVEKLLKGLK 237 + ++L L+ Sbjct: 345 NCDDISGYICQELKWKLE 362 >UniRef50_B0E5U4 NAD-dependent deacetylase sirtuin-2, putative n=2 Tax=Entamoeba RepID=B0E5U4_ENTDI Length = 383 Score = 205 bits (523), Expect = 1e-51, Method: Composition-based stats. Identities = 60/246 (24%), Positives = 92/246 (37%), Gaps = 19/246 (7%) Query: 4 PRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEG-FDRD--PELVQAFYNARR 59 ++ L GAG+S +GI FR+ GL+ + ++ PE FD + P FY + Sbjct: 135 KNIIALVGAGMSTTAGIPDFRSPGTGLYFNLQKYNLPYPEAVFDMNYFPSNPAPFYEVMK 194 Query: 60 RQLQ-QPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELLKV 116 Q + P H L L D G ++ TQNID L AG N VI HG Sbjct: 195 DMFPGQGKYFPTKCHRFLKLLNDK-GILKMVYTQNIDGLESVAGIPNDKVICSHGTFRTS 253 Query: 117 RCSQSGQVLDWTG---DVTPEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMAD 171 C + T + + + C ++P +V+F E + I D Sbjct: 254 HCLSCHKKYPDTSVFIESIKKGEIIRCSCGGLVKPDIVFFNESLPDEFFESIKNKFDDCD 313 Query: 172 IFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPS----QVGNE-FAEKYYGPASQVVP 226 + + IGT+ VYP A V ++ +N E N G + Sbjct: 314 MLLIIGTALVVYPFANLVDHVSINCPRVC-INREKVGKMMCYDNLGRDVALLGGCDDIAS 372 Query: 227 EFVEKL 232 + + L Sbjct: 373 DLAKYL 378 >UniRef50_A1ZPG8 NAD-dependent deacetylase n=1 Tax=Microscilla marina ATCC 23134 RepID=A1ZPG8_9SPHI Length = 278 Score = 205 bits (522), Expect = 1e-51, Method: Composition-based stats. Identities = 75/263 (28%), Positives = 118/263 (44%), Gaps = 31/263 (11%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLW----EEHRVEDVATPEGFDRDPELVQAFYNA 57 + + LTGAGISAESG+ T+R DG+W ++ E+ AT F +P V F Sbjct: 18 QDKLITFLTGAGISAESGVPTYRGTDGIWVEGSRNYKPEEFATLRFFKENPAEVWKFVLY 77 Query: 58 RRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNT--NVIHMHGELLK 115 R+ + ++QPNA HLALA + L + F L+TQNID LH +AGNT V+ +HG + Sbjct: 78 RK--VSFRDLQPNAGHLALASTEVLLPNNFRLITQNIDRLHIKAGNTQAKVLEIHGNMET 135 Query: 116 VRCSQSG-------------QVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMP----L 158 VRCS+ D ++ C + +RP+V+ F E Sbjct: 136 VRCSEECSMDVYPFPLDIGTAPYDAKMITQQWEQLKCPDCGSLMRPNVLMFDEYYNERLY 195 Query: 159 GMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFA---- 214 + A + +GTSG A G+ V++N+ S + Sbjct: 196 KQESAIEAALNTGVLFVVGTSGATNLPHHIASTATYRGSSLVDINIADSAFTDMATSEPD 255 Query: 215 -EKYYGPASQVVPEFVEKLLKGL 236 G + ++P+ ++L++ L Sbjct: 256 KLVLRGTSGDILPQI-KQLIQAL 277 >UniRef50_Q8IXJ6 NAD-dependent deacetylase sirtuin-2 n=43 Tax=Chordata RepID=SIRT2_HUMAN Length = 389 Score = 205 bits (522), Expect = 1e-51, Method: Composition-based stats. Identities = 58/227 (25%), Positives = 93/227 (40%), Gaps = 22/227 (9%) Query: 3 KPRVLVLTGAGISAESGIRTFRAA-DGLWEEHRVEDVATPEG------FDRDPELVQAFY 55 RV+ L GAGIS +GI FR+ GL++ + PE F + PE F+ Sbjct: 76 CRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPE---PFF 132 Query: 56 NARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGEL 113 A ++L + +P H + L+D G TQNID L AG +++ HG Sbjct: 133 -ALAKELYPGQFKPTICHYFMRLLKDK-GLLLRCYTQNIDTLERIAGLEQEDLVEAHGTF 190 Query: 114 LKVRCSQSGQVLDWTGDVTPED-----KCHCCQFPAPLRPHVVWFGE-MPLGMDEIYM-A 166 C + ++ E C + ++P +V+FGE +P Sbjct: 191 YTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQSD 250 Query: 167 LSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEF 213 D+ + +GTS V P A + +A L + +N E + + F Sbjct: 251 FLKVDLLLVMGTSLQVQPFASLISKAPLS-TPRLLINKEKAGQSDPF 296 >UniRef50_Q7VIN2 NAD-dependent deacetylase n=1 Tax=Helicobacter hepaticus RepID=NPD_HELHP Length = 255 Score = 204 bits (521), Expect = 1e-51, Method: Composition-based stats. Identities = 85/251 (33%), Positives = 129/251 (51%), Gaps = 25/251 (9%) Query: 4 PRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQ 63 P+++V +GAG+SAESG+ TFR GLW ++ +V E + + ELV FYN RR +L Sbjct: 2 PKLVVFSGAGLSAESGLETFRDNGGLWAQYDPMEVCNYENWLDNFELVHRFYNLRREEL- 60 Query: 64 QPEIQPNAAHLALAKL---------------QDALGDRFLLVTQNIDNLHERAGNTNVIH 108 ++QPNA H LA L + + +TQN+D+L ERAG +NVIH Sbjct: 61 -GKVQPNAMHKFLASLPMILNKPRIALSAKKKHKDPIEVIHITQNVDDLLERAGVSNVIH 119 Query: 109 MHGELLKVRCSQSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLG---MDEIYM 165 +HGEL K+ C Q + D C C + L+P +V+F E M +I+ Sbjct: 120 LHGELCKIICPQCEHIFDIGYTHFEPHNCPNCDY-GKLKPFIVFFYERAPKYVIMHDIFS 178 Query: 166 ALSMADIFIAIGTSGHVYPAAGFVHEA--KLHGAHTVELNLE--PSQVGNEFAEKYYGPA 221 LS D + IGTSG+V + + A + + + NL+ PS + F + +Y P Sbjct: 179 QLSSKDCVLVIGTSGNVVDISTILAFAESRARIGYKILNNLQYCPSIAESVFDKIFYKPT 238 Query: 222 SQVVPEFVEKL 232 +Q + E ++L Sbjct: 239 TQAIAEIEQEL 249 >UniRef50_D2NR35 NAD-dependent protein deacetylase n=2 Tax=Rothia mucilaginosa RepID=D2NR35_9MICC Length = 326 Score = 204 bits (521), Expect = 2e-51, Method: Composition-based stats. Identities = 70/274 (25%), Positives = 117/274 (42%), Gaps = 50/274 (18%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFY----- 55 ++ +VLVLTGAG+S ESGI +R G +HR T + F D Q ++ Sbjct: 59 LKAGKVLVLTGAGVSTESGIPDYRGPGGSLHDHRPM---TYQEFRYDDAARQRYWARSYV 115 Query: 56 NARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLK 115 RR + +PN AH ALA+L+ LG ++TQN+D LH RAG++ ++ +HG+L + Sbjct: 116 GWRRMR----RAEPNRAHYALAELEQ-LGAVSGVITQNVDGLHARAGSSRLLALHGDLSR 170 Query: 116 VRCSQSGQ---------------------------VLDWTGDVTPEDK-------CHCCQ 141 + C GQ ++ GDV +D+ C Sbjct: 171 IVCLDCGQDESRESLDTRLDAANLGYLARLEDEELRVNPDGDVELDDRYIRDFQMVPCLG 230 Query: 142 FPA-PLRPHVVWFGEMPLGMDEIYMA--LSMADIFIAIGTSGHVYPAAGFVHEAKLHGAH 198 + L+P VV+FGE + L+ + +G+S V + V EA G Sbjct: 231 CGSTRLKPDVVYFGESVPAERKALKDAMLAECSALLVVGSSVAVMSSYKIVLEALRAGKP 290 Query: 199 TVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 +N P + + + + + ++++ Sbjct: 291 VAVINGGPGRADAKATYLWRTGVGEALELMLDEI 324 >UniRef50_Q750H1 AGL018Cp n=1 Tax=Eremothecium gossypii RepID=Q750H1_ASHGO Length = 340 Score = 204 bits (520), Expect = 2e-51, Method: Composition-based stats. Identities = 64/253 (25%), Positives = 97/253 (38%), Gaps = 29/253 (11%) Query: 3 KPRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEG------FDRDPELVQAFY 55 K +V+ L GAGIS GI FR+ + GL+ + E F RDP + FY Sbjct: 21 KAKVVFLVGAGISTSCGIPDFRSPNTGLYHNLSKFKLPYAEAVFAIDYFQRDP---KPFY 77 Query: 56 NARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGEL 113 R ++ + P+ H L KL ++ G + TQNID L AG +I HG Sbjct: 78 TLAR-EMYPGKYIPSRFHY-LMKLFESKGYLKAVYTQNIDTLEREAGIAADYIIEAHGSF 135 Query: 114 LKVRCSQSGQVLD---WTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPL-----GMDEIYM 165 C + + + + C ++P +V+FGE D++ Sbjct: 136 ATNHCIDCDKTFPTETFKAMLESGEYARCEDCEGLIKPRIVFFGEDLPSVFYTSWDKLLS 195 Query: 166 ALSMA--D-IFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPS---QVGNEFAEKYYG 219 + D + I GTS VYP A E H V +N+E + + +G Sbjct: 196 EMQAGKEDYLVIVAGTSLVVYPFASLPSETP-RKVHRVLMNMEVVGDFKTPRKTDIIIHG 254 Query: 220 PASQVVPEFVEKL 232 + E L Sbjct: 255 ETDHIAEELARAL 267 >UniRef50_C4QWX8 Conserved NAD+ dependent histone deacetylase of the Sirtuin family n=1 Tax=Pichia pastoris GS115 RepID=C4QWX8_PICPG Length = 520 Score = 204 bits (520), Expect = 2e-51, Method: Composition-based stats. Identities = 67/283 (23%), Positives = 98/283 (34%), Gaps = 60/283 (21%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEH------RVEDVATPEGFDRDPELVQAFYN 56 +LVLTGAGIS GI FR+++G + + + V E F +DP L FY+ Sbjct: 181 SKNILVLTGAGISTSLGIPDFRSSEGFYTKLQEQGLDDPQTVFDLEYFKQDPSL---FYS 237 Query: 57 ARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELL 114 L PE H + L D G TQNIDNL AG + VI HG Sbjct: 238 IAHLVL-PPEGSFTPLHGFIKLLADK-GSLLRNYTQNIDNLEANAGIPSEKVIQCHGSFA 295 Query: 115 KVRCSQSGQVLDWTG-----DVTPEDKCHCC----------------------------- 140 C + + C C Sbjct: 296 TASCITCKYKIPGETIFEEIRNSELPLCPFCIKRRQKLIKEIEALDDSEQGISRHSFSFL 355 Query: 141 ---------QFPAPLRPHVVWFGEMPLGM--DEIYMALSMADIFIAIGTSGHVYPAAGFV 189 + ++P + +FGE + D I + D+ + IGTS V P + V Sbjct: 356 GSTVKRSYAESYGVMKPDITFFGEDLPRVFHDNIIQDVKNCDLLLCIGTSLKVAPVSEIV 415 Query: 190 HEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 ++ K V +N +P EF G +++ E + Sbjct: 416 NKVKPE-IPQVLINKDPVTHT-EFDISLLGYCDELIVYLCEAM 456 >UniRef50_C0W513 NAD-dependent deacetylase 1 n=4 Tax=Actinomycetaceae RepID=C0W513_9ACTO Length = 291 Score = 204 bits (520), Expect = 2e-51, Method: Composition-based stats. Identities = 72/268 (26%), Positives = 109/268 (40%), Gaps = 40/268 (14%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 M R L +TGAG+S ++GI +R + + F DP + + Sbjct: 30 MAGRRTLAVTGAGMSTDAGIPDYRGLG-----TTPVEPVDFQQFVSDPVWYRWVWACNHA 84 Query: 61 QLQQPEI-QPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCS 119 Q E +P H ALA+L++A G + TQN+D LH RAG + V +HG +V C Sbjct: 85 TWQLLEPLRPTPGHRALARLEEA-GYLTGVATQNVDRLHSRAGQSTVWELHGAYDRVVCL 143 Query: 120 QSGQVL--------------DWTGDVTPED------------------KCHCCQFPAPLR 147 + G+VL D+ P C + L+ Sbjct: 144 ECGRVLTRAEVDQRLSALNPDYPRQSDPARVAITPEADRAAAEACSFQTVTCSKCSGLLK 203 Query: 148 PHVVWFGE-MPLGMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEP 206 P +V+FGE +P M++ A D+ IA GTS V V +A GA V +N P Sbjct: 204 PDIVFFGESLPPAMEKAMQAAGECDVVIAAGTSLAVLTGLWIVRQAVAKGADLVVINRGP 263 Query: 207 SQVGNEFAEKYYGPASQVVPEFVEKLLK 234 + + G SQV+ ++L + Sbjct: 264 TAADELATIRVEGGTSQVLAAVADRLAR 291 >UniRef50_C5L233 NAD-dependent deacetylase sirtuin-5, putative n=2 Tax=Perkinsus marinus ATCC 50983 RepID=C5L233_9ALVE Length = 253 Score = 204 bits (519), Expect = 2e-51, Method: Composition-based stats. Identities = 82/234 (35%), Positives = 109/234 (46%), Gaps = 39/234 (16%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAA--DGLWEEH-RVEDVATPEGFDRDPELVQAFYNAR 58 E ++V+TGAG+SAESGI TFR GLW+E+ +ATPE F +P LV FY R Sbjct: 17 EAHHIVVITGAGVSAESGIPTFRGPGGGGLWQEYDDPTRLATPEAFAANPSLVWEFYEYR 76 Query: 59 RRQLQQPEIQPNAAHLALAKLQDAL---GDRFLLVTQNIDNLHERAGNTNVIHMHGELLK 115 R+ + PN H+ A+LQ G F L+TQN+D LH+ AG+ N+I +HG L Sbjct: 77 RKVVAA--ASPNTCHMWCAELQKIKENDGKDFTLMTQNVDRLHQAAGSHNIIELHGSLWL 134 Query: 116 V-RCSQSGQVLDWTGD-------------------VTPEDKCHC---------CQFPAPL 146 V + S + + D P D H + L Sbjct: 135 VKKSSDAAHTHTFIEDGVNVWEDRNVPITPAFANIDQPPDHHHHITVPIGELPHRDGRLL 194 Query: 147 RPHVVWFGEMPLG--MDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAH 198 RP VVWFGE + A+S D+ + +GTS VYPAAGF A Sbjct: 195 RPAVVWFGEALDKDTLASANKAMSSCDLLLVLGTSSVVYPAAGFADTALKRNIP 248 >UniRef50_A9V9C1 Predicted protein n=1 Tax=Monosiga brevicollis RepID=A9V9C1_MONBE Length = 340 Score = 204 bits (519), Expect = 3e-51, Method: Composition-based stats. Identities = 57/208 (27%), Positives = 88/208 (42%), Gaps = 14/208 (6%) Query: 9 LTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEG-FDRD--PELVQAFYNARRRQLQQ 64 + GAGIS +GI FR+ GL++ + D+ PE F D +AF+ ++L Sbjct: 1 MAGAGISTSAGIPDFRSPGTGLYDNLQKYDLPYPEAIFTLDYLRSKPEAFFTLA-KELYP 59 Query: 65 PEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTN--VIHMHGELLKVRCSQSG 122 P H + LQD G TQNID L AG + ++ HG + C Sbjct: 60 GNFDPTPCHYFIKLLQDK-GVLLRHYTQNIDTLERAAGVRDDLLVEAHGSFAQAACIDCS 118 Query: 123 QVLD--WTGDVTPEDKCHCCQ-FPAPLRPHVVWFGE-MPLGMDEIY-MALSMADIFIAIG 177 D W +D C+ ++P +V+FGE +P ++ D+ I +G Sbjct: 119 HRHDTEWVKSQIDKDAVPRCESCGGIVKPSIVFFGEDLPRRFGQLVSEDFEKCDLLIVLG 178 Query: 178 TSGHVYPAAGFVHEAKLHGAHTVELNLE 205 TS V+P AG K + +N + Sbjct: 179 TSLTVHPFAGLATMPKPE-VPRLLINRD 205 >UniRef50_B6JXE7 Sir2 family histone deacetylase Hst2 n=1 Tax=Schizosaccharomyces japonicus yFS275 RepID=B6JXE7_SCHJY Length = 374 Score = 204 bits (519), Expect = 3e-51, Method: Composition-based stats. Identities = 59/242 (24%), Positives = 93/242 (38%), Gaps = 19/242 (7%) Query: 4 PRVLVLTGAGISAESGIRTFRAAD----GLWEEHRVEDVATPEGFDRDPELVQAFYNARR 59 + V+ GAGIS +GI FR D L+ E + E F +P + F+ Sbjct: 25 KNICVMVGAGISTAAGIPDFRRHDLLKHFLFNLPYAEAIFDLEYFRENP---KPFFELA- 80 Query: 60 RQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELLKVR 117 +L P H L +L + G TQNID L AG ++ HG R Sbjct: 81 YELMPGRYMPTPTHYFL-RLMNEKGLMLRCFTQNIDTLERIAGVPEDKIVEAHGSFQYNR 139 Query: 118 CSQSGQVLD--WTGDVT-PEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMADI 172 C + ++ D + +D C + ++P +V++GE D +Y + D+ Sbjct: 140 CIECKEMADSGYVRHCIETKDVPLCEKCKGYVKPTIVFYGEGLPSRFFDCMYEDMEKCDL 199 Query: 173 FIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQ--VGNEFAEKYYGPASQVVPEFVE 230 + IGTS V+P A A + +N E E G +V + + Sbjct: 200 ALVIGTSLLVHPFADLPEIATENCQRL-LINREVVGDFSERESDLMVLGDCDALVRQLCK 258 Query: 231 KL 232 L Sbjct: 259 YL 260 >UniRef50_Q71W25 NAD-dependent deacetylase n=32 Tax=Bacilli RepID=NPD_LISMF Length = 229 Score = 203 bits (518), Expect = 3e-51, Method: Composition-based stats. Identities = 62/230 (26%), Positives = 103/230 (44%), Gaps = 13/230 (5%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHR-VEDVATPEGFDRDPELVQAFYNARRR 60 + ++ LTGAG+S SGI +R+ +GL+ E + + R+PE FY Sbjct: 10 KAEHIVFLTGAGVSVPSGIPDYRSKNGLYAGMSSPEYMLSHTCLVREPE---KFYQFVTE 66 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 + P+ +PNA H +A+++ ++TQNID LHE+AG+ V++ HG L C + Sbjct: 67 NMYYPDAEPNAIHTKMAEIEAE--KDVTIITQNIDGLHEKAGSKKVVNFHGSLYHCYCQK 124 Query: 121 SGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGE-MPL-GMDEIYMALSMADIFIAIGT 178 G + + + +RP VV + E +P +D+ A+ AD+ + +GT Sbjct: 125 CGMSVTAEEYLKSDIHS---GCGGVIRPDVVLYEEAIPESAIDQSLAAIRQADLIVIVGT 181 Query: 179 SGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEF 228 S V P + A +N E + F A +V E Sbjct: 182 SFRVSPFCNLTDY-RNKKARIFAVNKEQISLPYPFEM-MESDAVKVFAEI 229 >UniRef50_B3RZX6 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens RepID=B3RZX6_TRIAD Length = 337 Score = 203 bits (518), Expect = 3e-51, Method: Composition-based stats. Identities = 62/230 (26%), Positives = 97/230 (42%), Gaps = 26/230 (11%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAAD-GL-------WEEHRVEDVATPEGFDRDPELVQA 53 E ++V+TGAG+S +GI FR+ D GL ++ E V + + F +P + Sbjct: 43 ECKNIIVMTGAGLSTAAGIPDFRSPDIGLFTKVMQKYQVTSPELVFSIDYFHENPSV--- 99 Query: 54 FYNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHG 111 FY R + + + +P AH L L D TQN+D L AG V+ HG Sbjct: 100 FYEMSR-GMTETDYKPTIAHYFLKLLADK-NLLLRHYTQNVDGLDLAAGLSEDKVVTAHG 157 Query: 112 ELLKVRCSQSGQVLDWTGDVTPED--------KCHCCQFPAPLRPHVVWFGE-MPLGMDE 162 + C+ S +T + + C + ++P VV +GE +P Sbjct: 158 TMYTAHCTTSECHTKYTLEWLKQQLLKTPDITVPRCDKCQGVIKPDVVLYGEQLPNKFFT 217 Query: 163 IYMA-LSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGN 211 + A D+ I +GTS V P A V H A + +NLE + + Sbjct: 218 MRSADFPNCDLLIIMGTSLKVEPFASLVEHVPEH-APRLLINLEETGQDH 266 >UniRef50_Q8N6T7 NAD-dependent deacetylase sirtuin-6 n=24 Tax=Metazoa RepID=SIRT6_HUMAN Length = 355 Score = 203 bits (517), Expect = 4e-51, Method: Composition-based stats. Identities = 61/247 (24%), Positives = 97/247 (39%), Gaps = 36/247 (14%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 + V+ TGAGIS SGI FR G+W T E P+ F +AR Sbjct: 43 QSSSVVFHTGAGISTASGIPDFRGPHGVW---------TMEERGLAPKFDTTFESAR--- 90 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELLKVRCS 119 P H+AL +L+ +G LV+QN+D LH R+G + +HG + C+ Sbjct: 91 -------PTQTHMALVQLER-VGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECA 142 Query: 120 QSGQVLDW------TGDVTPEDKCHCCQ------FPAPLRPHVV-WFGEMP-LGMDEIYM 165 + G C + LR ++ W +P + Sbjct: 143 KCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRACRGELRDTILDWEDSLPDRDLALADE 202 Query: 166 ALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVV 225 A AD+ I +GTS + P+ K G V +NL+P++ + +G +V+ Sbjct: 203 ASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVM 262 Query: 226 PEFVEKL 232 ++ L Sbjct: 263 TRLMKHL 269 >UniRef50_C5MB00 NAD-dependent histone deacetylase SIR2 n=2 Tax=Saccharomycetales RepID=C5MB00_CANTT Length = 601 Score = 203 bits (516), Expect = 6e-51, Method: Composition-based stats. Identities = 68/263 (25%), Positives = 99/263 (37%), Gaps = 39/263 (14%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEH------RVEDVATPEGFDRDPELVQAFY 55 + ++LV+TGAGIS GI FR++ G + ++V E F DP L FY Sbjct: 250 KSNKILVITGAGISTSLGIPDFRSSKGFYSMVQHLGLSDPQEVFDLELFHIDPSL---FY 306 Query: 56 NARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGN--TNVIHMHGEL 113 + L PE + H + LQD G TQNIDNL AG ++ HG Sbjct: 307 SIAHMIL-PPEKMFSPMHSFIRVLQDH-GKLLRNYTQNIDNLESYAGISKEKLVQCHGSF 364 Query: 114 LKVRCSQSGQVL---DWTGDVTPEDKCHCCQFP-------------------APLRPHVV 151 C G + D + ++ C Q +P + Sbjct: 365 ATASCVTCGYRINGEDIFDKIRAKEIPLCQQCTKHKTDILKRDEDYYFADSYGVFKPDIT 424 Query: 152 WFGE-MPLGM-DEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQV 209 +FGE +P D I + D+ I GTS V P + V + + +N + Sbjct: 425 FFGEALPSNFHDHIREDILECDLLICAGTSLKVAPVSDIVDKVPEK-IPQILINKDSITH 483 Query: 210 GNEFAEKYYGPASQVVPEFVEKL 232 N F G +VV +KL Sbjct: 484 CN-FDVSLLGYCDEVVSYVADKL 505 >UniRef50_C7TMK6 NAD-dependent protein deacetylase, SIR2 family n=12 Tax=Bacilli RepID=C7TMK6_LACRL Length = 230 Score = 203 bits (516), Expect = 6e-51, Method: Composition-based stats. Identities = 63/230 (27%), Positives = 103/230 (44%), Gaps = 14/230 (6%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWE-EHRVEDVATPEGFDRDPELVQAFYNARRR 60 + V +TGAG+S SGI +R+ GL+ + E + + E F+ Sbjct: 10 QAKYVTFMTGAGVSTASGIPDYRSKGGLYADKVDPEYALSIDNLQAHHE---DFHEFVVN 66 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 + P+ +PN H +A + + G +VTQN+D L +AG +V+ HG L ++ C Q Sbjct: 67 NMYYPDAKPNVIHEKMAAISNQKG---AIVTQNVDGLDRQAGAKHVVEFHGNLYRIYCQQ 123 Query: 121 SGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGE--MPLGMDEIYMALSMADIFIAIGT 178 Q D+ + + LRP +V +GE P + A++ AD+ I +GT Sbjct: 124 CHQHFDYQTYLKSDVHAA---DGGILRPDIVLYGEPINPDTVSAAINAIASADLLIVVGT 180 Query: 179 SGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEF 228 S VYP AG + A+ A V +N E + G A+ + + Sbjct: 181 SFVVYPFAGLIGYAQPD-ATIVAVNREQIALPQGGHMVL-GDATDIFADL 228 >UniRef50_Q5KDE0 NAD-dependent histone deacetylase, putative n=2 Tax=Filobasidiella neoformans RepID=Q5KDE0_CRYNE Length = 413 Score = 202 bits (515), Expect = 8e-51, Method: Composition-based stats. Identities = 56/227 (24%), Positives = 85/227 (37%), Gaps = 30/227 (13%) Query: 3 KPRVLVLTGAGISAESGIRTFRAA-DGLWEEHRVEDVATPEG------FDRDPELVQAFY 55 V+ L GAGIS +GI FR+ GL+ + ++ PE F R PE Sbjct: 72 AKDVIFLLGAGISTSAGIPDFRSPSTGLYHNLQALELPFPEAVFELGFFQRRPEPFW--- 128 Query: 56 NARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTN--VIHMHGEL 113 +++ P H L +L + + TQNID L AG ++ HG Sbjct: 129 -TLAKEIYPGRHFPTPTHY-LLQLFNRHNLLKRVFTQNIDTLETLAGLPPHLIVEAHGSF 186 Query: 114 LKVRCSQSGQVLDWTG--------------DVTPEDKCHCCQFPAPLRPHVVWFGE-MPL 158 C + + +D D T + + ++P +V+FGE +P Sbjct: 187 ATAHCLKCRREVDREEVLKAGVRKGEVVRCDATLKAMGKGKKCGGLVKPDIVFFGEGLPD 246 Query: 159 GMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLE 205 ++ L D+ I IGTS V P A V +N E Sbjct: 247 RFFKLVPELRKCDLLIVIGTSLQVQPFASLVDYVPSTCPRL-LINRE 292 >UniRef50_Q8R104 NAD-dependent deacetylase sirtuin-3 n=14 Tax=Deuterostomia RepID=SIRT3_MOUSE Length = 257 Score = 202 bits (514), Expect = 9e-51, Method: Composition-based stats. Identities = 62/241 (25%), Positives = 97/241 (40%), Gaps = 23/241 (9%) Query: 9 LTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEG------FDRDPELVQAFYNARRRQ 61 + GAGIS SGI FR+ GL+ + D+ PE F +P + F+ ++ Sbjct: 1 MVGAGISTPSGIPDFRSPGSGLYSNLQQYDIPYPEAIFELGFFFHNP---KPFF-MLAKE 56 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELLKVRCS 119 L +PN H L L D L TQNID L +G + ++ HG + C+ Sbjct: 57 LYPGHYRPNVTHYFLRLLHDKE-LLLRLYTQNIDGLERASGIPASKLVEAHGTFVTATCT 115 Query: 120 QSGQVL---DWTGDVTPEDKCHCCQFPAPLRPHVVWFGE-MPLGMDEIYMALSMADIFIA 175 + D DV + C ++P +V+FGE +P ++AD+ + Sbjct: 116 VCRRSFPGEDIWADVMADRVPRCPVCTGVVKPDIVFFGEQLPARFLLHMADFALADLLLI 175 Query: 176 IGTSGHVYPAAGFVHEAKLHGAHTVELNLE---PSQVGNEFAEKYY-GPASQVVPEFVEK 231 +GTS V P A EA + +N + P + + G V V+ Sbjct: 176 LGTSLEVEPFASL-SEAVQKSVPRLLINRDLVGPFVLSPRRKDVVQLGDVVHGVERLVDL 234 Query: 232 L 232 L Sbjct: 235 L 235 >UniRef50_P53686 NAD-dependent deacetylase HST2 n=7 Tax=Saccharomycetaceae RepID=HST2_YEAST Length = 357 Score = 202 bits (514), Expect = 1e-50, Method: Composition-based stats. Identities = 65/263 (24%), Positives = 97/263 (36%), Gaps = 42/263 (15%) Query: 5 RVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEG------FDRDPELVQAFYNA 57 +V+ + GAGIS GI FR+ GL+ + PE F DP FY Sbjct: 26 KVIFMVGAGISTSCGIPDFRSPGTGLYHNLARLKLPYPEAVFDVDFFQSDP---LPFYTL 82 Query: 58 RRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTN--VIHMHGELLK 115 ++L +P+ H L QD + TQNID L +AG + +I HG Sbjct: 83 A-KELYPGNFRPSKFHYLLKLFQDKD-VLKRVYTQNIDTLERQAGVKDDLIIEAHGSFAH 140 Query: 116 VRCSQSGQVLD------WTGDVTPEDKCHCCQFPAPLRPHVVWFGE-MPLGMDEIY---- 164 C G+V + +D C ++P +V+FGE +P E + Sbjct: 141 CHCIGCGKVYPPQVFKSKLAEHPIKDFVKCDVCGELVKPAIVFFGEDLPDSFSETWLNDS 200 Query: 165 MALSMA----------DIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEF- 213 L + I +GTS VYP A E V NLE + + Sbjct: 201 EWLREKITTSGKHPQQPLVIVVGTSLAVYPFASLPEEIP-RKVKRVLCNLE-TVGDFKAN 258 Query: 214 ----AEKYYGPASQVVPEFVEKL 232 + + + + VE+L Sbjct: 259 KRPTDLIVHQYSDEFAEQLVEEL 281 >UniRef50_O59923 NAD-dependent histone deacetylase SIR2 n=4 Tax=Candida albicans RepID=SIR2_CANAL Length = 515 Score = 202 bits (514), Expect = 1e-50, Method: Composition-based stats. Identities = 62/251 (24%), Positives = 99/251 (39%), Gaps = 24/251 (9%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEG-FDRDPELVQA--FYNARR 59 +++V+TGAGIS GI FR+ GL+ + +++ P+ FD + + FY Sbjct: 234 AKKIMVVTGAGISTSLGIPDFRSFKGLYNQLSKLNLSDPQKVFDLQTFMREGRLFYTIAH 293 Query: 60 RQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELLKVR 117 L P+ + + H L LQD TQNIDNL +RAG + ++ HG K + Sbjct: 294 LVL-PPDGKFSLLHAFLKLLQDKH-KLLRNYTQNIDNLEQRAGLKSEKLVQCHGSFAKAK 351 Query: 118 CSQSGQVLDWTGDV-----TPEDKCHCCQFP--------APLRPHVVWFGE-MPLGMDEI 163 C + +C C ++P + +FGE +P + Sbjct: 352 CVSCQGIFAGEKIYNHIRRKQVPRCAICWKNTKQAPIHFGAIKPTITFFGEDLPERFHTL 411 Query: 164 Y-MALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPAS 222 L D+F+ IGTS V P A + + +N +P F + G Sbjct: 412 MDKDLQQIDLFLVIGTSLKVEPVASIIERVPYK-VPKILINKDPIP-NRGFNLQLLGLCD 469 Query: 223 QVVPEFVEKLL 233 V + L Sbjct: 470 DAVSYLCKCLK 480 >UniRef50_Q5GUM2 SIR2-like regulatory protein n=5 Tax=cellular organisms RepID=Q5GUM2_XANOR Length = 357 Score = 201 bits (513), Expect = 1e-50, Method: Composition-based stats. Identities = 70/260 (26%), Positives = 105/260 (40%), Gaps = 41/260 (15%) Query: 4 PRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQ 63 R+ VLTGAG S +SGI +R G W+ + T + F + Q ++ R + Sbjct: 84 QRLFVLTGAGCSTDSGIPDYRDLQGGWKRPQP---VTFQAFMGELSTRQRYW--ARSLVG 138 Query: 64 QPEI---QPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 P QPNA H ALA L+ G +L+TQN+D LH+ AG+ VI +HG L VRC Sbjct: 139 WPRFGLAQPNATHHALAALEAR-GQLEVLLTQNVDRLHQAAGSQAVIDLHGRLDVVRCMG 197 Query: 121 SGQVLDWTGDVTPEDK------------------------------CHCCQFPAPLRPHV 150 + + T ++ C L+P V Sbjct: 198 CERRMPRTEFQLLLEQANPGWAAREAAQAPDGDADLDDVAFEHFVVPPCPVCGGVLKPDV 257 Query: 151 VWFGEMPL--GMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQ 208 V+FGE ++ + L AD + +G+S VY FV A +G LN+ ++ Sbjct: 258 VFFGENVPRERVERAFAHLQAADAVLVVGSSLMVYSGFRFVQTAARNGLPIAALNVGHTR 317 Query: 209 VGNEFAEKYYGPASQVVPEF 228 K +Q + Sbjct: 318 ADELLTLKVEQSCAQALAFL 337 >UniRef50_Q4UZX0 NAD-dependent deacetylase n=94 Tax=Bacteria RepID=NPD_XANC8 Length = 293 Score = 201 bits (512), Expect = 2e-50, Method: Composition-based stats. Identities = 71/260 (27%), Positives = 106/260 (40%), Gaps = 41/260 (15%) Query: 4 PRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQ 63 R+ VL+GAG S +SGI +R G W+ + T + F + Q ++ R + Sbjct: 20 QRLFVLSGAGCSTDSGIPDYRDLQGGWKRPQP---VTFQAFMGELSTRQRYW--ARSLVG 74 Query: 64 QPEI---QPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 P +PNA H ALA L+ A G LL+TQN+D LH+ AG+ VI +HG L VRC Sbjct: 75 WPRFGLARPNATHHALAALE-ARGQLELLLTQNVDRLHQAAGSQAVIDLHGRLDVVRCMG 133 Query: 121 SGQVLDWTGDVTPEDK------------------------------CHCCQFPAPLRPHV 150 Q + T ++ C L+P V Sbjct: 134 CEQRMPRTEFQLLLERDNPGWADLEAAQAPDGDADLDNVAFDNFVVPACPACGGVLKPDV 193 Query: 151 VWFGEMPL--GMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQ 208 V+FGE ++ + L AD + +G+S VY FV A G LN ++ Sbjct: 194 VFFGENVPRERVERAFAHLQAADAVLVVGSSLMVYSGFRFVQAAARAGLPIAALNFGRTR 253 Query: 209 VGNEFAEKYYGPASQVVPEF 228 + + K +Q + Sbjct: 254 ADDLLSLKVEQSCAQALAFL 273 >UniRef50_Q8FUC8 NAD-dependent deacetylase 1 n=11 Tax=Corynebacterium RepID=NPD1_COREF Length = 281 Score = 201 bits (511), Expect = 2e-50, Method: Composition-based stats. Identities = 70/270 (25%), Positives = 111/270 (41%), Gaps = 42/270 (15%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 +E VL +TGAG+S +SGI +R+ G + R T + F DP ++ Sbjct: 14 LEAGSVLAVTGAGVSTDSGIPDYRSPRGSLNQGRPM---TYQEFRFDPVASHRYWARSFV 70 Query: 61 QLQ-QPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCS 119 + + QPN H AL +L+ A G +VTQN+D LH RAG+ N++ +HG+L + C Sbjct: 71 GWRVMADAQPNRTHYALVELERA-GLLSGIVTQNVDGLHRRAGSENLVALHGDLATIVCL 129 Query: 120 QSGQV---------------------------LDWTGDVTPEDKC-------HCCQFPAP 145 Q G ++ GDVT +D C + + Sbjct: 130 QCGHREARELLDARLDHLNPGYFDSIALDPSAVNPDGDVTLDDHHVQRFTMAGCARCGSV 189 Query: 146 -LRPHVVWFGEMPLGMD--EIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVEL 202 L+P VV+FGE + + L AD + G+S V V EA+ G + Sbjct: 190 LLKPDVVYFGEPVPSIRKTRVAQLLDGADAVVVAGSSLAVMSGYRIVIEAQRAGKPVAVI 249 Query: 203 NLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 N P + + + + ++ L Sbjct: 250 NGGPGRADHRVDILWRTRVGPAFDQILDAL 279 >UniRef50_C1BMY9 NAD-dependent deacetylase sirtuin-2 n=3 Tax=Caligidae RepID=C1BMY9_9MAXI Length = 305 Score = 201 bits (511), Expect = 2e-50, Method: Composition-based stats. Identities = 61/265 (23%), Positives = 99/265 (37%), Gaps = 42/265 (15%) Query: 4 PRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEG------FDRDPELVQAFYN 56 +++L+GAGIS +GI FR+ GL+ + + ++ PE F +DP FY+ Sbjct: 32 KNIVILSGAGISTNAGIPDFRSPSLGLYFKLKKYNLPYPEAVFEGSYFRKDP---LPFYS 88 Query: 57 ARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELL 114 R ++ ++P H L + TQNID L AG + ++ HG Sbjct: 89 LVR-EIYPSRLEPTLTHKF-LSLLSKKKLLRRVFTQNIDGLEGLAGIPSEEIVEAHGSFA 146 Query: 115 KVRCSQSGQVLDWT--------GDVTPEDKCHCCQFPAPLRPHVVWFGE-MPLGMDEIYM 165 + C+ + + T + C +RP VV FGE MP ++ Sbjct: 147 RSYCTSCKREYELTWLKREIFAAQESNGGVPKCESCSGIVRPDVVLFGESMPPRFSQLAE 206 Query: 166 A-LSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPS----------------- 207 + L AD+ + IGTS V P G V G V ++ Sbjct: 207 SELKKADLLLVIGTSLAVAPFNGLVGLT-QSGTPRVYISKTRPGQSNSLLGKVLGLNSSI 265 Query: 208 QVGNEFAEKYYGPASQVVPEFVEKL 232 + + VV + +L Sbjct: 266 RFEEDTDLVLLDDCDAVVLQICRQL 290 >UniRef50_Q4P1X1 Putative uncharacterized protein n=1 Tax=Ustilago maydis RepID=Q4P1X1_USTMA Length = 434 Score = 201 bits (511), Expect = 2e-50, Method: Composition-based stats. Identities = 62/232 (26%), Positives = 87/232 (37%), Gaps = 35/232 (15%) Query: 4 PRVLVLTGAGISAESG--IRTFRAAD-GLWEEHRVEDVATPEG------FDRDPELVQAF 54 V+VL GAGIS + I FR+ GL+ ++ E F R P Q F Sbjct: 49 RNVIVLAGAGISTSASPPIPDFRSPGTGLYANLAAYNLPYAEAIFDIGYFQRHP---QPF 105 Query: 55 YNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGE 112 + + L +P AH L LQ + TQN+D L AG V+ HG Sbjct: 106 FTLAKH-LYPGNFKPALAHYFLTLLQRK-QKLKRVFTQNVDTLERIAGVEADKVVEAHGS 163 Query: 113 LLKVRCSQSGQVLDW--------TGDVTPEDKCHCC---------QFPAPLRPHVVWFGE 155 C +D +G V + C Q ++P +V+FGE Sbjct: 164 FATSTCIVCKHSVDDDWIRNKVESGQVARCPRPKCPGRKTGSKGEQRGGLVKPDIVFFGE 223 Query: 156 -MPLGMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEP 206 +P L AD+ I +GTS V P A + A + +NLE Sbjct: 224 SLPPRFFRCIPDLKTADLLIVMGTSLQVQPFASLID-AVPATCPRLLINLER 274 >UniRef50_A1U4N6 Silent information regulator protein Sir2 n=2 Tax=Marinobacter RepID=A1U4N6_MARAV Length = 298 Score = 201 bits (511), Expect = 2e-50, Method: Composition-based stats. Identities = 67/266 (25%), Positives = 109/266 (40%), Gaps = 42/266 (15%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 + PR+++LTGAG+S +SGI +R DG W+ + + F D Q ++ R Sbjct: 40 QHPRLMILTGAGVSTDSGIPDYRDGDGAWKRKQP---VQHKAFMEDFHTRQRYW--ARSL 94 Query: 62 LQQPEIQ---PNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRC 118 + P ++ PN +H ++ L+ L L+VTQN+D LH++AG V +HG +V C Sbjct: 95 IGWPVMRNAAPNPSHHYISDLE-LLNHSSLVVTQNVDRLHQKAGTRAVTDLHGRADEVVC 153 Query: 119 SQSGQVL-----------------------------DWTGDVTPEDKCHCCQFPAPLRPH 149 G D D + C + L+P Sbjct: 154 MGCGYRCPRDEVHDRCAELNPGFRKYTAETAPDGDADLDVDFSEFRPVDCPRCAGILKPD 213 Query: 150 VVWFGEMPLGMDEIYMA---LSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEP 206 VV+FG+ D +Y A L +D + IG+S VY F A LNL Sbjct: 214 VVFFGDYVPK-DRVYSALDVLKASDGLLVIGSSLMVYSGFRFCRYASEWKKPIATLNLGR 272 Query: 207 SQVGNEFAEKYYGPASQVVPEFVEKL 232 ++ + K + + +++L Sbjct: 273 TRAEDLVDLKLNARIGETLKASLDQL 298 >UniRef50_UPI000186DFC4 NAD-dependent deacetylase sirtuin-4, putative n=1 Tax=Pediculus humanus corporis RepID=UPI000186DFC4 Length = 316 Score = 200 bits (510), Expect = 3e-50, Method: Composition-based stats. Identities = 62/269 (23%), Positives = 111/269 (41%), Gaps = 44/269 (16%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWE--EHRVEDVATPEGFDRDPELVQAFYNARR 59 + V VLTGAG+S ESGI +R+ GL++ ++R D +T F ++ ++ R Sbjct: 49 KNSSVAVLTGAGVSTESGIPDYRSETGLYKRTKYRPIDYST---FLKNKAARIRYW--AR 103 Query: 60 RQLQQPEI---QPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKV 116 + PE +PN H AL +L +A G ++TQN+D LH +A N+I +HG V Sbjct: 104 NYVGWPEFSSKEPNGTHFAL-QLYEAAGKVSGIITQNVDGLHHKASGHNIIELHGNAYWV 162 Query: 117 RCSQSG---------QVLDWTGDVTPE----------------------DKCHCCQFPAP 145 +C ++LD E C + Sbjct: 163 KCLSCKNLIFRHDFQKILDALNPSVQETGKIFVRPDGDVEIDESVYENFKIPDCEKCGGI 222 Query: 146 LRPHVVWFGEMPLG--MDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELN 203 L+P +V+FG+ + + + +D + +GT+ + V +A + +N Sbjct: 223 LKPTIVFFGDNVPKVTVKKAENLIESSDALLVMGTTLSTLSSLRIVTQAFDLCKYICIVN 282 Query: 204 LEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 L ++ S+++P + +L Sbjct: 283 LGETRGDKMADIVINAKCSEILPNYNREL 311 >UniRef50_Q839C6 NAD-dependent deacetylase n=22 Tax=Bacilli RepID=NPD_ENTFA Length = 237 Score = 200 bits (510), Expect = 3e-50, Method: Composition-based stats. Identities = 61/228 (26%), Positives = 104/228 (45%), Gaps = 14/228 (6%) Query: 4 PRVLVLTGAGISAESGIRTFRAADGLWEEHR-VEDVATPEGFDRDPELVQAFYNARRRQL 62 ++ LTGAGIS SG+ +R+ G+++ + E + + +PE F + L Sbjct: 17 QKITFLTGAGISTASGVPDYRSLKGVYQGIQQPEYLLSRTCLKTEPEKFYQF----VKTL 72 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG 122 P+ QPN H +A+L+ R +V+QNID LH +AG+ V+ HG L + C G Sbjct: 73 YHPDAQPNIIHQKMAQLEQM--KRGKIVSQNIDGLHRKAGSQEVVDFHGNLYECYCQTCG 130 Query: 123 QVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGE--MPLGMDEIYMALSMADIFIAIGTSG 180 + W D D+ C +RP + + E +++ A++ AD+ + +GTS Sbjct: 131 ATVPW-QDYLLSDRHADCH--GQIRPAITLYEEGLSEEAIEKAIQAVASADLIVIVGTSF 187 Query: 181 HVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEF 228 V+P +H K A + +N P + + A + E Sbjct: 188 QVHPFCDLIHY-KQPTATILAINQTPLFLQQPY-YFLEAKAETIFAEL 233 >UniRef50_B3S4A5 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens RepID=B3S4A5_TRIAD Length = 295 Score = 200 bits (509), Expect = 4e-50, Method: Composition-based stats. Identities = 55/260 (21%), Positives = 109/260 (41%), Gaps = 33/260 (12%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEGFDRDPELVQAFYNARR 59 ++ ++L+LTGAG+S SGI +R+ GL+ + + + D + + Sbjct: 31 LKSKKLLILTGAGVSTASGIPDYRSKGVGLYARSNQRPMQYSDFLENDENRKRYWSRNFT 90 Query: 60 RQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCS 119 + ++PN H +AKL+ L +VTQN+D LH+RAG++ + +HG + +V C Sbjct: 91 GWSRFSSVKPNLTHNFIAKLEQ-LKLLHWVVTQNVDGLHQRAGSSRLTELHGTMHEVICL 149 Query: 120 QSGQVL--------------DWT---------------GDVTPEDKCHCCQFPAPLRPHV 150 Q +++ +WT + + C+ L+P+V Sbjct: 150 QCQKIILRREFQDILSKLNPNWTVKSIQTAPDADVFIAENEVMKFNLAKCECGGVLKPNV 209 Query: 151 VWFGEMPLGM--DEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQ 208 V+FG +E+ + AD + +G+S Y A + A +++ ++ Sbjct: 210 VFFGGSISKDINEEVRQHVDEADSILVVGSSLQTYSAYRIISRASDMRKPIGIVSIGETR 269 Query: 209 VGNEFAEKYYGPASQVVPEF 228 + + K +Q+ Sbjct: 270 ADHLASFKISINCNQLFENL 289 >UniRef50_A4VDQ9 Chromatin regulatory protein sir2 n=1 Tax=Tetrahymena thermophila SB210 RepID=A4VDQ9_TETTH Length = 279 Score = 200 bits (509), Expect = 4e-50, Method: Composition-based stats. Identities = 68/244 (27%), Positives = 112/244 (45%), Gaps = 26/244 (10%) Query: 4 PRVLVLTGAGISAESGIRTFRAAD-GLWEEHR-------VEDVATPEGFDRDPELVQAFY 55 +++VLTGAGIS +GI FR+ D GL+ + E + T + + ++ + FY Sbjct: 31 KKIIVLTGAGISTNAGIPDFRSKDTGLYARLKKSGQFSYPEQIFTIDYYQQN---HKPFY 87 Query: 56 NARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTN--VIHMHGEL 113 R +Q+ E +P +H + +L +L +TQNID L +AG +I HG L Sbjct: 88 EICREFVQK-EYEPQQSHKFITELA-KQNLLYLNITQNIDGLELKAGLDKKYLIQAHGNL 145 Query: 114 LKVRCSQSGQ----VLDWTGDVTPEDKCHCCQ---FPAPLRPHVVWFGE-MPLGMDEIYM 165 K C + + G + +D +C + L+P V +FGE +P +I + Sbjct: 146 EKSHCIECHKEDTIEYFKEGVLKSDDAVNCRKTKNCQGKLKPSVTFFGEKLPFYFYKIPL 205 Query: 166 ALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVV 225 + AD+ I +GTS V P A + K V LN E V ++ + G + + Sbjct: 206 QMRFADLIIVMGTSLKVQPFASLLSY-KSKSTPLVVLNSE--NVVSDCSLFIGGDIDKNL 262 Query: 226 PEFV 229 E + Sbjct: 263 EEIM 266 >UniRef50_A9DQY7 Silent information regulator protein Sir2 n=1 Tax=Kordia algicida OT-1 RepID=A9DQY7_9FLAO Length = 276 Score = 200 bits (509), Expect = 4e-50, Method: Composition-based stats. Identities = 81/264 (30%), Positives = 128/264 (48%), Gaps = 31/264 (11%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLW----EEHRVEDVATPEGFDRDPELVQAFYNA 57 ++ + LTGAG+SA SGI T+R+ DG+W + H+ E+ T F ++ E V F Sbjct: 16 KRNNITFLTGAGLSAASGIPTYRSTDGIWVKGTKYHKPEEFGTFSYFSKNQEEVWQFNLF 75 Query: 58 RRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNT--NVIHMHGELLK 115 R+ Q + QPN +H LAK++ + + F ++TQNID LH+R GN+ V +HG + Sbjct: 76 RKGMFQ--KAQPNDSHKLLAKIEKLIPEEFSIITQNIDGLHQRGGNSGNKVFEIHGNMRT 133 Query: 116 VRCS-QSGQVL-----DWTGDVTPE-------DKCHCCQFPAPLRPHVVWFGEMP----L 158 VRCS + + + D T D + DK C + A +RP+++WF E Sbjct: 134 VRCSLECSKAVYLYPKDITIDRIDQDLTDDIWDKLECPKCGAVMRPNILWFDEYYNERLY 193 Query: 159 GMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQV-----GNEF 213 +D I I IGTSG V + +G + +++NLE + + G + Sbjct: 194 KVDSTMRIAKNTGILIVIGTSGATTLPLELVKQTLKYGGYVLDVNLEDNNITKLIEGKKR 253 Query: 214 AEKYYGPASQVVPEFVEKLLKGLK 237 Y + + EF +LK L Sbjct: 254 VVSYRTTSDAFLSEF-HNILKELM 276 >UniRef50_Q75DM1 ABL004Wp n=1 Tax=Eremothecium gossypii RepID=Q75DM1_ASHGO Length = 319 Score = 199 bits (508), Expect = 5e-50, Method: Composition-based stats. Identities = 85/294 (28%), Positives = 128/294 (43%), Gaps = 65/294 (22%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 ++L + GAG+SA SG+ TF+AA G W H ++ATPE F +PELV FY+ARR Sbjct: 18 ARKILCIVGAGLSASSGLTTFQAAHGEWRGHSALELATPEAFQENPELVWVFYSARR--Y 75 Query: 63 QQPEIQPNAAHLALAKLQDALG----DRFLLVTQNIDNLHERAGNT--NVIHMHGELLKV 116 + +PN H ALA+L + LLVTQN+D LH RAG + + +HG + Sbjct: 76 TAMKARPNNGHFALAELCRRVAADERREILLVTQNVDGLHWRAGQPEASTVELHGSVFDY 135 Query: 117 RCSQ--SG---------------------------------------------QVLDWTG 129 RC++ + L Sbjct: 136 RCTEFLCSYRGRNVRDHFLTAGLRAHTPRELPRPAAAEEPENKRAKHACEGTPETLRSRL 195 Query: 130 DVTPEDKCHCCQFP-APLRPHVVWFGEMP-----LGMDEIYMALSMADIFIAIGTSGHVY 183 D+ D C + LRP VVW GE +D A D+ + IGTSG ++ Sbjct: 196 DMLRGDLPRCPRCRVGLLRPGVVWCGESLSLVQMDRVDAFLSAKQKVDLVLVIGTSGRLW 255 Query: 184 PAAGFVHEAKLHGAHTVELNLEPSQVG----NEFAEKYYGPASQVVPEFVEKLL 233 PA G+V A+L G+ N + N+ + G A++++P+ +E ++ Sbjct: 256 PAMGYVERAQLCGSRIAFFNTDIEDAAGVAKNKRMWAFQGNAAELLPQALEPVI 309 Searching..................................................done Results from round 3 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_D2LLI1 Silent information regulator protein Sir2 n=3 Ta... 282 5e-75 UniRef50_C8S918 Silent information regulator protein Sir2 n=1 Ta... 274 2e-72 UniRef50_D0KGP3 Silent information regulator protein Sir2 n=11 T... 271 2e-71 UniRef50_O30124 NAD-dependent deacetylase 2 n=18 Tax=cellular or... 271 2e-71 UniRef50_A0LP75 Silent information regulator protein Sir2 n=3 Ta... 267 2e-70 UniRef50_A8MBU4 NAD-dependent deacetylase n=14 Tax=cellular orga... 267 3e-70 UniRef50_Q9CM50 NAD-dependent deacetylase n=5 Tax=Proteobacteria... 263 4e-69 UniRef50_Q8R9N6 NAD-dependent deacetylase 1 n=2 Tax=Thermoanaero... 261 2e-68 UniRef50_UPI00016C4DD0 Silent information regulator protein Sir2... 260 2e-68 UniRef50_A9A3X3 Silent information regulator protein Sir2 n=4 Ta... 257 2e-67 UniRef50_C6A243 NAD-dependent deacetylase n=8 Tax=Euryarchaeota ... 256 4e-67 UniRef50_Q72IV5 NAD-dependent deacetylase n=8 Tax=Bacteria RepID... 256 4e-67 UniRef50_B1L5P3 NAD-dependent protein deacetylase, SIR2 family n... 256 5e-67 UniRef50_B8KDE3 NAD-dependent deacetylase n=4 Tax=Gammaproteobac... 256 6e-67 UniRef50_Q2LSF2 Sir2 family of NAD+-dependent deacetylase n=2 Ta... 255 6e-67 UniRef50_Q8ZU41 NAD-dependent deacetylase 1 n=4 Tax=Pyrobaculum ... 252 6e-66 UniRef50_Q5L014 NAD-dependent deacetylase 1 n=8 Tax=Firmicutes R... 251 1e-65 UniRef50_Q2RZG2 Transcriptional regulator, Sir2 family n=2 Tax=B... 250 2e-65 UniRef50_C8QW70 Silent information regulator protein Sir2 n=1 Ta... 249 6e-65 UniRef50_B5Y820 Putative NAD-dependent deacetylase 2 n=1 Tax=Cop... 248 1e-64 UniRef50_C9R9I3 Silent information regulator protein Sir2 n=1 Ta... 247 3e-64 UniRef50_B0EU66 NAD-dependent deacetylase, putative n=2 Tax=Enta... 247 3e-64 UniRef50_B2A496 Silent information regulator protein Sir2 n=1 Ta... 246 5e-64 UniRef50_Q46ZJ9 Silent information regulator protein Sir2 n=4 Ta... 245 7e-64 UniRef50_B0VHF0 NAD-dependent deacetylase (Regulatory protein SI... 245 7e-64 UniRef50_C1XSL0 NAD-dependent protein deacetylase, SIR2 family n... 245 8e-64 UniRef50_A6LP94 Silent information regulator protein Sir2 n=1 Ta... 245 8e-64 UniRef50_Q2YZT2 Putative uncharacterized protein n=1 Tax=uncultu... 245 1e-63 UniRef50_B7IF48 NAD-dependent deacetylase n=1 Tax=Thermosipho af... 244 2e-63 UniRef50_Q8F3Z6 NAD-dependent deacetylase n=4 Tax=Leptospira Rep... 244 2e-63 UniRef50_Q6MJJ2 NAD-dependent deacetylase n=8 Tax=Proteobacteria... 242 8e-63 UniRef50_Q9WYW0 NAD-dependent deacetylase n=5 Tax=Thermotogaceae... 242 9e-63 UniRef50_Q81BT4 NAD-dependent deacetylase n=75 Tax=Bacillus RepI... 242 1e-62 UniRef50_B0SCR8 NAD-dependent protein deacetylase, SIR2 family n... 240 2e-62 UniRef50_A9GVG5 Transcriptional regulatory protein, Sir2 family ... 240 2e-62 UniRef50_P66814 NAD-dependent deacetylase n=12 Tax=Mycobacterium... 239 5e-62 UniRef50_Q1QDL3 Silent information regulator protein Sir2 n=6 Ta... 239 7e-62 UniRef50_A4J646 Silent information regulator protein Sir2 n=2 Ta... 239 9e-62 UniRef50_C1FAB6 Putative nicotinic acid mononucleotide:5, 6-dime... 238 1e-61 UniRef50_B5YJW3 NAD-dependent deacetylase n=1 Tax=Thermodesulfov... 238 1e-61 UniRef50_D2R126 Silent information regulator protein Sir2 n=1 Ta... 238 2e-61 UniRef50_B1I1N5 Silent information regulator protein Sir2 n=1 Ta... 237 3e-61 UniRef50_B1MER1 NAD-dependent deacetylase (Regulatory protein Si... 236 4e-61 UniRef50_Q8Y015 NAD-dependent deacetylase n=20 Tax=cellular orga... 236 5e-61 UniRef50_C8X5T0 Silent information regulator protein Sir2 n=3 Ta... 235 1e-60 UniRef50_C7FPB6 NAD-dependent protein deacetylase n=4 Tax=enviro... 234 2e-60 UniRef50_C6P8W9 Silent information regulator protein Sir2 n=2 Ta... 234 3e-60 UniRef50_Q97MB4 NAD-dependent deacetylase n=71 Tax=cellular orga... 234 3e-60 UniRef50_C6BY08 Silent information regulator protein Sir2 n=1 Ta... 233 3e-60 UniRef50_A6DC77 Silent information regulator protein Sir2 n=1 Ta... 233 4e-60 UniRef50_A0LG97 Silent information regulator protein Sir2 n=1 Ta... 233 4e-60 UniRef50_Q1D737 NAD-dependent deacetylase n=1 Tax=Myxococcus xan... 233 4e-60 UniRef50_C0GT54 Silent information regulator protein Sir2 n=1 Ta... 233 4e-60 UniRef50_Q88BY5 NAD-dependent deacetylase n=11 Tax=Pseudomonas R... 233 5e-60 UniRef50_A7HL19 Silent information regulator protein Sir2 n=1 Ta... 232 6e-60 UniRef50_A7XXV9 Sirtuin 5 n=14 Tax=Eumetazoa RepID=A7XXV9_PIG 232 6e-60 UniRef50_O07595 NAD-dependent deacetylase n=5 Tax=Bacillus RepID... 232 8e-60 UniRef50_UPI0001757F4E PREDICTED: similar to NAD-dependent deace... 232 1e-59 UniRef50_Q9NXA8 NAD-dependent deacetylase sirtuin-5 n=37 Tax=Met... 232 1e-59 UniRef50_Q8NSM4 NAD-dependent deacetylase n=15 Tax=Corynebacteri... 232 1e-59 UniRef50_B3EMB2 Silent information regulator protein Sir2 n=2 Ta... 231 1e-59 UniRef50_Q67KQ0 NAD-dependent deacetylase n=1 Tax=Symbiobacteriu... 230 3e-59 UniRef50_C5CGD1 Silent information regulator protein Sir2 n=3 Ta... 230 3e-59 UniRef50_Q96EB6 NAD-dependent deacetylase sirtuin-1 n=36 Tax=Eut... 230 3e-59 UniRef50_C6CZ67 Silent information regulator protein Sir2 n=1 Ta... 230 3e-59 UniRef50_B9L9A0 NAD-dependent deacetylase n=4 Tax=Bacteria RepID... 229 7e-59 UniRef50_A8VRI8 NAD-dependent protein deacetylase SIR2 family-li... 229 9e-59 UniRef50_UPI000186E50A snf2 histone linker PHD ring helicase, pu... 229 1e-58 UniRef50_Q73KE1 NAD-dependent deacetylase n=2 Tax=Treponema RepI... 228 1e-58 UniRef50_C4GC77 Putative uncharacterized protein n=3 Tax=Clostri... 228 1e-58 UniRef50_C2AS85 NAD-dependent protein deacetylase, SIR2 family n... 228 1e-58 UniRef50_Q899G3 NAD-dependent deacetylase n=52 Tax=Bacteria RepI... 227 2e-58 UniRef50_B1LZ70 Silent information regulator protein Sir2 n=6 Ta... 227 2e-58 UniRef50_UPI0001C3128D Silent information regulator protein Sir2... 227 2e-58 UniRef50_C7RQR7 Silent information regulator protein Sir2 n=1 Ta... 227 2e-58 UniRef50_D2QCS2 Silent information regulator protein Sir2 n=29 T... 227 3e-58 UniRef50_D0WS10 NAD-dependent deacetylase n=2 Tax=Actinomyces Re... 226 4e-58 UniRef50_B6KET2 NAD-dependent deacetylase, putative n=3 Tax=Toxo... 226 4e-58 UniRef50_UPI000179269F PREDICTED: similar to sirtuin n=1 Tax=Acy... 226 4e-58 UniRef50_A9AWT4 Silent information regulator protein Sir2 n=1 Ta... 226 5e-58 UniRef50_B0S0T6 Transcriptional regulator Sir2 family n=4 Tax=Cl... 226 6e-58 UniRef50_Q1RPU3 Zinc finger protein (Fragment) n=1 Tax=Ciona int... 226 6e-58 UniRef50_D1UAS5 Silent information regulator protein Sir2 n=1 Ta... 225 7e-58 UniRef50_C0GF21 Silent information regulator protein Sir2 n=1 Ta... 225 1e-57 UniRef50_B0EBU9 NAD-dependent deacetylase, putative n=3 Tax=Enta... 225 1e-57 UniRef50_C4FX59 Putative uncharacterized protein n=1 Tax=Catonel... 224 2e-57 UniRef50_B8F955 Silent information regulator protein Sir2 n=1 Ta... 224 2e-57 UniRef50_D2RNB5 Silent information regulator protein Sir2 n=1 Ta... 224 2e-57 UniRef50_A5UYK2 Silent information regulator protein Sir2 n=2 Ta... 224 3e-57 UniRef50_C1SNI0 NAD-dependent protein deacetylase, SIR2 family n... 223 3e-57 UniRef50_D1A1X3 Silent information regulator protein Sir2 n=13 T... 223 4e-57 UniRef50_UPI000186F273 NAD-dependent deacetylase HST1, putative ... 222 6e-57 UniRef50_UPI000051AA14 PREDICTED: similar to NAD-dependent deace... 222 6e-57 UniRef50_Q8R984 NAD-dependent deacetylase 2 n=9 Tax=Thermoanaero... 222 7e-57 UniRef50_Q5WKC8 NAD-dependent deacetylase n=7 Tax=Bacillaceae Re... 222 1e-56 UniRef50_B3T8H4 Putative Sir2 family protein n=1 Tax=uncultured ... 222 1e-56 UniRef50_A1DG07 SIR2 family histone deacetylase, putative n=8 Ta... 222 1e-56 UniRef50_A9A0B2 NAD-dependent deacetylase n=1 Tax=Desulfococcus ... 221 1e-56 UniRef50_Q89LY4 NAD-dependent deacetylase 1 n=18 Tax=Proteobacte... 220 2e-56 UniRef50_D0NEH2 NAD-dependent histone deacetylase sir2-like prot... 220 3e-56 UniRef50_C1AAZ7 NAD-dependent deacetylase n=4 Tax=Bacteria RepID... 219 5e-56 UniRef50_Q0AY57 Regulatory protein, sir2 family n=1 Tax=Syntroph... 219 5e-56 UniRef50_A9AWG1 Silent information regulator protein Sir2 n=3 Ta... 219 6e-56 UniRef50_Q9I4L0 NAD-dependent deacetylase 1 n=28 Tax=Bacteria Re... 219 6e-56 UniRef50_B8FEP4 Silent information regulator protein Sir2 n=1 Ta... 219 8e-56 UniRef50_C3IUP0 SIR2 n=2 Tax=Bacillus thuringiensis RepID=C3IUP0... 218 1e-55 UniRef50_Q6BVM7 DEHA2C01386p n=4 Tax=Saccharomycetaceae RepID=Q6... 218 1e-55 UniRef50_A5USR3 Silent information regulator protein Sir2 n=3 Ta... 218 2e-55 UniRef50_C1VAT1 NAD-dependent protein deacetylase, SIR2 family n... 217 2e-55 UniRef50_Q12Y78 NAD-dependent deacetylase, Sir2-like n=1 Tax=Met... 217 2e-55 UniRef50_UPI0001925E2D PREDICTED: similar to NAD-dependent deace... 217 2e-55 UniRef50_Q8CJM9 NAD-dependent deacetylase 2 n=8 Tax=Actinomyceta... 217 2e-55 UniRef50_A2QFF9 Complex: Sir2p is one of four Silent Information... 216 5e-55 UniRef50_B0CZ35 Class I sirtuins SIR2 family protein n=2 Tax=Aga... 216 5e-55 UniRef50_A6TNA0 Silent information regulator protein Sir2 n=2 Ta... 216 7e-55 UniRef50_B4VCV9 SIR2 family transcriptional regulator n=3 Tax=Ac... 216 7e-55 UniRef50_Q21921 NAD-dependent deacetylase SIR2 homolog n=2 Tax=C... 215 7e-55 UniRef50_D2RWQ5 Silent information regulator protein Sir2 n=2 Ta... 215 1e-54 UniRef50_A3ZMQ7 Sir2 family, possible ADP ribosyltransferase n=1... 215 1e-54 UniRef50_C3WP91 SIR2 family protein n=9 Tax=Fusobacterium RepID=... 215 1e-54 UniRef50_B9E751 Putative uncharacterized protein n=1 Tax=Macroco... 215 1e-54 UniRef50_Q5KZE8 NAD-dependent deacetylase 2 n=8 Tax=Bacteria Rep... 215 1e-54 UniRef50_D1N1D6 Silent information regulator protein Sir2 n=1 Ta... 214 2e-54 UniRef50_O96505 SIR2 n=15 Tax=Arthropoda RepID=O96505_DROME 214 2e-54 UniRef50_C4QC33 Chromatin regulatory protein sir2, putative n=1 ... 214 3e-54 UniRef50_C6XKE4 Silent information regulator protein Sir2 n=1 Ta... 213 3e-54 UniRef50_C6AKY4 Transcriptional regulator, Sir2 family n=5 Tax=P... 213 3e-54 UniRef50_Q8CNF4 NAD-dependent deacetylase n=64 Tax=Staphylococcu... 213 4e-54 UniRef50_A7EC18 Putative uncharacterized protein n=1 Tax=Sclerot... 212 6e-54 UniRef50_Q8REC3 NAD-dependent deacetylase n=8 Tax=Fusobacterium ... 212 7e-54 UniRef50_B2ARI4 Predicted CDS Pa_4_7390 (Fragment) n=1 Tax=Podos... 212 9e-54 UniRef50_C0S0X1 NAD-dependent deacetylase sirtuin-2 n=3 Tax=Para... 212 1e-53 UniRef50_Q8A3H9 NAD-dependent deacetylase n=29 Tax=Bacteria RepI... 211 1e-53 UniRef50_D2VWA2 Silent information regulator family protein n=1 ... 211 2e-53 UniRef50_C4Q5J6 Chromatin regulatory protein sir2, putative n=2 ... 211 2e-53 UniRef50_UPI00015B57C0 PREDICTED: similar to GA18743-PA n=1 Tax=... 211 2e-53 UniRef50_C8W9D8 Silent information regulator protein Sir2 n=2 Ta... 210 2e-53 UniRef50_Q9FE17 Sir2-like protein n=13 Tax=Viridiplantae RepID=Q... 210 5e-53 UniRef50_A9BHU8 Silent information regulator protein Sir2 n=3 Ta... 210 5e-53 UniRef50_Q6BPH5 DEHA2E13596p n=4 Tax=Saccharomycetaceae RepID=Q6... 209 8e-53 UniRef50_Q9Y6E7 NAD-dependent ADP-ribosyltransferase sirtuin-4 n... 209 8e-53 UniRef50_Q607X6 NAD-dependent deacetylase n=2 Tax=Gammaproteobac... 208 8e-53 UniRef50_D1B8J6 Silent information regulator protein Sir2 n=1 Ta... 208 1e-52 UniRef50_Q5V4Q5 NAD-dependent deacetylase n=3 Tax=Halobacteriace... 208 1e-52 UniRef50_Q54GV7 NAD(+)-dependent deacetylase, silent information... 208 1e-52 UniRef50_A8NWP2 Putative uncharacterized protein n=1 Tax=Coprino... 208 1e-52 UniRef50_C6Y0J4 Silent information regulator protein Sir2 n=1 Ta... 208 2e-52 UniRef50_C5CY53 Silent information regulator protein Sir2 n=1 Ta... 207 2e-52 UniRef50_Q1QTH0 Silent information regulator protein Sir2 n=3 Ta... 207 2e-52 UniRef50_Q0CI01 Putative uncharacterized protein n=2 Tax=Leotiom... 207 2e-52 UniRef50_B8JAI9 Silent information regulator protein Sir2 n=5 Ta... 207 3e-52 UniRef50_D2RCH9 Transcriptional regulator, Sir2 family n=7 Tax=B... 207 4e-52 UniRef50_A2QWZ2 Function: human SIRT5 belongs to the Sir2-like p... 207 4e-52 UniRef50_Q3A6W7 NAD-dependent protein deacetylases, SIR2 family ... 207 4e-52 UniRef50_A4QUX8 Putative uncharacterized protein n=1 Tax=Magnapo... 206 4e-52 UniRef50_B3RLQ5 Putative uncharacterized protein n=1 Tax=Trichop... 206 5e-52 UniRef50_B2VWU1 NAD-dependent deacetylase sirtuin-5 n=3 Tax=Leot... 206 6e-52 UniRef50_D2Q7L2 SIR2 family protein n=13 Tax=Bifidobacterium Rep... 205 7e-52 UniRef50_B6GXN1 Pc12g08000 protein n=1 Tax=Penicillium chrysogen... 205 9e-52 UniRef50_A0NQ49 Silent information regulator protein Sir2 n=2 Ta... 205 1e-51 UniRef50_C4R311 NAD(+)-dependent histone deacetylase n=3 Tax=Sac... 205 2e-51 UniRef50_C3YDA2 Putative uncharacterized protein n=1 Tax=Branchi... 204 2e-51 UniRef50_C4WX51 ACYPI009170 protein n=1 Tax=Acyrthosiphon pisum ... 204 2e-51 UniRef50_Q6C8C7 YALI0D20724p n=1 Tax=Yarrowia lipolytica RepID=Q... 204 2e-51 UniRef50_UPI000186DFC4 NAD-dependent deacetylase sirtuin-4, puta... 203 3e-51 UniRef50_Q3V7G9 NAD-dependent deacetylase (Regulatory protein si... 203 3e-51 UniRef50_C4XZ95 Putative uncharacterized protein n=1 Tax=Clavisp... 203 5e-51 UniRef50_D2A3P1 Putative uncharacterized protein GLEAN_14968 n=1... 203 6e-51 UniRef50_Q5R1T8 NAD-dependent deacetylase sirtuin 2 homolog n=2 ... 202 6e-51 UniRef50_A8PZF9 NAD-dependent deacetylase SIRT1, putative n=1 Ta... 202 8e-51 UniRef50_B6JXE7 Sir2 family histone deacetylase Hst2 n=1 Tax=Sch... 202 8e-51 UniRef50_B3WAV7 NAD-dependent deacetylase (Regulatory protein SI... 202 1e-50 UniRef50_Q1YSP9 NAD-dependent deacetylase n=1 Tax=gamma proteoba... 202 1e-50 UniRef50_Q9NTG7 NAD-dependent deacetylase sirtuin-3, mitochondri... 202 1e-50 UniRef50_B0D7T5 Predicted protein n=3 Tax=Agaricales RepID=B0D7T... 201 1e-50 UniRef50_B3RYT4 Putative uncharacterized protein (Fragment) n=1 ... 201 1e-50 UniRef50_D2S8Y6 Silent information regulator protein Sir2 n=1 Ta... 201 1e-50 UniRef50_Q9I7I7 Sirt2 n=8 Tax=Drosophila RepID=Q9I7I7_DROME 201 1e-50 UniRef50_B9GC62 Putative uncharacterized protein n=1 Tax=Oryza s... 201 1e-50 UniRef50_Q9USN7 NAD-dependent deacetylase hst2 n=1 Tax=Schizosac... 201 2e-50 UniRef50_A9NEY3 Putative uncharacterized protein n=1 Tax=Acholep... 201 2e-50 UniRef50_Q298C7 GA18650 n=3 Tax=Drosophila RepID=Q298C7_DROPS 201 2e-50 UniRef50_C5M5U2 NAD-dependent histone deacetylase SIR2 n=2 Tax=C... 201 2e-50 UniRef50_C6X5T5 NAD-dependent protein deacetylase of SIR2 family... 201 2e-50 UniRef50_Q7ZVK3 NAD-dependent deacetylase sirtuin-2 n=19 Tax=Euk... 201 2e-50 UniRef50_A9SDL4 SIR2 family protein n=2 Tax=Physcomitrella paten... 200 2e-50 UniRef50_C5LN96 Neurofilament triplet L protein, putative n=5 Ta... 200 3e-50 UniRef50_UPI0001744E27 NAD-dependent protein deacetylases, SIR2 ... 200 3e-50 UniRef50_B3L8U3 Transcriptional regulatory protein sir2 homologu... 200 4e-50 UniRef50_C9M9P4 Transcriptional regulator, Sir2 family n=1 Tax=J... 199 5e-50 UniRef50_C4QWX8 Conserved NAD+ dependent histone deacetylase of ... 199 6e-50 UniRef50_UPI00019255E8 PREDICTED: similar to sirtuin n=2 Tax=Hyd... 199 6e-50 UniRef50_Q8N6T7 NAD-dependent deacetylase sirtuin-6 n=24 Tax=Met... 199 7e-50 UniRef50_C0W513 NAD-dependent deacetylase 1 n=4 Tax=Actinomyceta... 199 8e-50 UniRef50_D2VK77 Putative uncharacterized protein n=1 Tax=Naegler... 199 8e-50 UniRef50_A8PNK8 Transcriptional regulator, Sir2 family protein n... 199 8e-50 UniRef50_A3LRA1 Transcriptional regulatory protein n=4 Tax=Sacch... 198 1e-49 UniRef50_Q5HU51 NAD-dependent deacetylase n=15 Tax=Campylobacter... 198 1e-49 UniRef50_A4S2L7 Predicted protein n=2 Tax=Ostreococcus RepID=A4S... 198 2e-49 UniRef50_B9L4G7 NAD-dependent deacetylase 1 (Regulatory protein ... 198 2e-49 UniRef50_C4XFR7 Putative uncharacterized protein n=1 Tax=Mycopla... 197 2e-49 UniRef50_C4M6Q0 Sir2 family transcriptional regulator, putative ... 197 2e-49 UniRef50_C5MB00 NAD-dependent histone deacetylase SIR2 n=2 Tax=S... 197 2e-49 UniRef50_B7U9B0 Sirtuin 3 n=7 Tax=Chordata RepID=B7U9B0_PIG 197 3e-49 UniRef50_O59923 NAD-dependent histone deacetylase SIR2 n=4 Tax=C... 197 3e-49 UniRef50_C5GPX3 SIR2 family histone deacetylase n=2 Tax=Ajellomy... 197 4e-49 UniRef50_A8NIK3 Putative uncharacterized protein n=1 Tax=Coprino... 196 5e-49 UniRef50_Q8IXJ6 NAD-dependent deacetylase sirtuin-2 n=43 Tax=Cho... 196 5e-49 UniRef50_B3RZX6 Putative uncharacterized protein n=1 Tax=Trichop... 196 6e-49 UniRef50_Q4UZX0 NAD-dependent deacetylase n=94 Tax=Bacteria RepI... 196 6e-49 UniRef50_A7SK95 Predicted protein n=1 Tax=Nematostella vectensis... 196 7e-49 UniRef50_A3LN35 NAD-dependent histone deacetylase SIR2 (Regulato... 195 1e-48 UniRef50_B3S4A5 Putative uncharacterized protein n=1 Tax=Trichop... 195 1e-48 UniRef50_B2ATE5 Predicted CDS Pa_1_15580 n=4 Tax=Sordariomyceta ... 195 1e-48 UniRef50_A5DJ74 Putative uncharacterized protein n=2 Tax=Pichia ... 195 1e-48 UniRef50_Q07FY7 Sirtuin (Silent mating type information regulati... 194 2e-48 UniRef50_D2Q1M5 Silent information regulator protein Sir2 n=7 Ta... 194 2e-48 UniRef50_C5L8Y4 Chromatin regulatory protein sir2, putative n=2 ... 194 2e-48 UniRef50_B3QYR0 Silent information regulator protein Sir2 n=1 Ta... 194 2e-48 UniRef50_C7NJ50 NAD-dependent protein deacetylase, SIR2 family n... 194 3e-48 UniRef50_A7RLD5 Predicted protein (Fragment) n=1 Tax=Nematostell... 194 3e-48 UniRef50_Q9ZJW8 NAD-dependent deacetylase n=58 Tax=Bacteria RepI... 193 3e-48 UniRef50_Q5GUM2 SIR2-like regulatory protein n=5 Tax=cellular or... 193 3e-48 UniRef50_B0E5U4 NAD-dependent deacetylase sirtuin-2, putative n=... 193 3e-48 UniRef50_A0C6J0 Chromosome undetermined scaffold_152, whole geno... 193 3e-48 UniRef50_B6H5J7 Pc14g00270 protein n=6 Tax=Trichocomaceae RepID=... 193 4e-48 UniRef50_Q9NRC8 NAD-dependent deacetylase sirtuin-7 n=27 Tax=Coe... 193 5e-48 UniRef50_B9W8S7 SIR2-family NAD-dependent histone deacetylase, p... 193 6e-48 UniRef50_B2AR57 Predicted CDS Pa_4_8570 n=1 Tax=Podospora anseri... 193 6e-48 UniRef50_A8I1B6 NADH-dependent histone deacetylase (Fragment) n=... 192 6e-48 UniRef50_A5DNV7 Putative uncharacterized protein n=2 Tax=Pichia ... 192 6e-48 UniRef50_Q8R104 NAD-dependent deacetylase sirtuin-3 n=14 Tax=Deu... 192 7e-48 UniRef50_Q8FUC8 NAD-dependent deacetylase 1 n=11 Tax=Corynebacte... 192 8e-48 UniRef50_D2VCI1 Silent information regulator family protein n=2 ... 192 8e-48 UniRef50_A1U4N6 Silent information regulator protein Sir2 n=2 Ta... 192 9e-48 UniRef50_Q5KDE0 NAD-dependent histone deacetylase, putative n=2 ... 192 9e-48 UniRef50_D1B334 Silent information regulator protein Sir2 n=2 Ta... 192 1e-47 UniRef50_A1ZPG8 NAD-dependent deacetylase n=1 Tax=Microscilla ma... 192 1e-47 UniRef50_C8VEG1 SIR2 family histone deacetylase, putative (AFU_o... 192 1e-47 UniRef50_D1Y076 Transcriptional regulator, Sir2 family n=1 Tax=P... 192 1e-47 UniRef50_D2NR35 NAD-dependent protein deacetylase n=2 Tax=Rothia... 192 1e-47 UniRef50_C1BMY9 NAD-dependent deacetylase sirtuin-2 n=3 Tax=Cali... 192 1e-47 UniRef50_C1BNZ8 NAD-dependent deacetylase sirtuin-2 n=3 Tax=Cali... 191 1e-47 UniRef50_UPI00006CB0CC transcriptional regulator, Sir2 family pr... 191 2e-47 UniRef50_Q71W25 NAD-dependent deacetylase n=32 Tax=Bacilli RepID... 191 2e-47 UniRef50_B7QJK7 Chromatin regulatory protein sir2, putative n=1 ... 191 2e-47 UniRef50_A1HU63 Silent information regulator protein Sir2 n=1 Ta... 190 2e-47 UniRef50_Q2KEK3 Putative uncharacterized protein n=2 Tax=Magnapo... 190 3e-47 UniRef50_Q6C219 YALI0F11583p n=1 Tax=Yarrowia lipolytica RepID=Q... 190 3e-47 UniRef50_Q1RPU9 Zinc finger protein (Fragment) n=2 Tax=Ciona int... 190 3e-47 Sequences not found previously or not previously below threshold: >UniRef50_D2LLI1 Silent information regulator protein Sir2 n=3 Tax=Aciduliprofundum boonei T469 RepID=D2LLI1_9EURY Length = 245 Score = 282 bits (723), Expect = 5e-75, Method: Composition-based stats. Identities = 94/239 (39%), Positives = 130/239 (54%), Gaps = 4/239 (1%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 + R++ LTGAGISAESGI TFR GLWE + VE VAT EGF+RDP LV FY+ RRR Sbjct: 11 LSAKRIVALTGAGISAESGIPTFRGTGGLWEGYPVEKVATIEGFERDPALVWKFYDERRR 70 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 + + +PN AH LA ++ F ++TQNID LH RAG+ NV+ +HG + +V+C++ Sbjct: 71 NI--AKARPNRAHEVLALFENLY--DFWVITQNIDGLHSRAGSKNVVELHGNIWRVKCTE 126 Query: 121 SGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSG 180 G E C + LRP VVWFGE +D+ Y D+ + IGTS Sbjct: 127 CGIRYYNYEVPLREIPPKCKRCGGLLRPDVVWFGEPVYDVDKAYELTESCDVMLVIGTSA 186 Query: 181 HVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKGLKAG 239 VYPAA A GA +E+N + + + A++ + E LL+ + Sbjct: 187 QVYPAAYLPRLAWSKGAKIIEINPQETPISRYANFVIREKATKALDELYRGLLRAFQEE 245 >UniRef50_C8S918 Silent information regulator protein Sir2 n=1 Tax=Ferroglobus placidus DSM 10642 RepID=C8S918_FERPL Length = 253 Score = 274 bits (700), Expect = 2e-72, Method: Composition-based stats. Identities = 89/237 (37%), Positives = 129/237 (54%), Gaps = 11/237 (4%) Query: 7 LVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQPE 66 +V TGAG+SAESGI TFR DGLW ++VA+ GF R+P F R + + + Sbjct: 21 VVFTGAGVSAESGIPTFRGNDGLWRRWDPDEVASIYGFRRNPRKFWEF---SRELIVKVK 77 Query: 67 IQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVLD 126 QPN AH A+A+L+ +G ++TQNID LH+RAG+ V+ +HG + V C G+ Sbjct: 78 AQPNPAHYAIAELE-KMGLVKAVITQNIDMLHQRAGSKRVLELHGSMQYVDCLDCGKTYK 136 Query: 127 WTGDVTPEDKCH----CCQFPAP-LRPHVVWFGEMPLG--MDEIYMALSMADIFIAIGTS 179 W +K C+ + L+P VV+FGE + E AD+FI +G+S Sbjct: 137 WEEIERFLEKGEIDKIRCECGSIYLKPRVVFFGEPLPSNVLSEAMEESRRADVFIVVGSS 196 Query: 180 GHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKGL 236 VYPAA AK HGA + +NLEP+ + F G A +V+PE V+++ + Sbjct: 197 LVVYPAAYLPVIAKEHGAKLIIVNLEPTMKDHIFDVVIRGKAGEVMPEIVKRVKTLI 253 >UniRef50_D0KGP3 Silent information regulator protein Sir2 n=11 Tax=Proteobacteria RepID=D0KGP3_PECWW Length = 276 Score = 271 bits (693), Expect = 2e-71, Method: Composition-based stats. Identities = 187/229 (81%), Positives = 203/229 (88%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 M+KPRV+VLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGF RDPELVQ FYNARRR Sbjct: 36 MKKPRVVVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFQRDPELVQEFYNARRR 95 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 QLQQPEI PNAAHLALA L+ L D F L+TQNIDNLHERAG+ VIHMHGELLK+RCSQ Sbjct: 96 QLQQPEIVPNAAHLALANLEAMLEDNFQLITQNIDNLHERAGSRRVIHMHGELLKIRCSQ 155 Query: 121 SGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSG 180 SGQ+ +WT D+ ++CHCCQFPAPLRPHVVWFGEMPL MD+IY ALS AD FIAIGTSG Sbjct: 156 SGQIFEWTDDLAAGERCHCCQFPAPLRPHVVWFGEMPLHMDKIYHALSQADYFIAIGTSG 215 Query: 181 HVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFV 229 HVYPAAGFVHEA HGA+T+ELNLEPSQV ++F EK YGPAS VVPEFV Sbjct: 216 HVYPAAGFVHEAHSHGAYTLELNLEPSQVESQFDEKIYGPASAVVPEFV 264 >UniRef50_O30124 NAD-dependent deacetylase 2 n=18 Tax=cellular organisms RepID=NPD2_ARCFU Length = 253 Score = 271 bits (693), Expect = 2e-71, Method: Composition-based stats. Identities = 86/241 (35%), Positives = 127/241 (52%), Gaps = 10/241 (4%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 + +V TGAGISAESGI TFR DGLW ++ E+VA+ GF R+P F + + Sbjct: 14 KSKHAVVFTGAGISAESGIPTFRGEDGLWRKYDPEEVASISGFKRNPRAFWEFSMEMKDK 73 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 L +PN AH A+A+L+ +G ++TQNID LH+RAG+ V+ +HG + K+ C Sbjct: 74 LF---AEPNPAHYAIAELE-RMGIVKAVITQNIDMLHQRAGSRRVLELHGSMDKLDCLDC 129 Query: 122 GQVLDW---TGDVTPEDKCHCCQFP-APLRPHVVWFGEMPLG--MDEIYMALSMADIFIA 175 + DW D + C + ++P VV FGE + E D F+ Sbjct: 130 HETYDWSEFVEDFNKGEIPRCRKCGSYYVKPRVVLFGEPLPQRTLFEAIEEAKHCDAFMV 189 Query: 176 IGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKG 235 +G+S VYPAA + AK GA + +N EP+ F K G A +V+P+ VE++ + Sbjct: 190 VGSSLVVYPAAELPYIAKKAGAKMIIVNAEPTMADPIFDVKIIGKAGEVLPKIVEEVKRL 249 Query: 236 L 236 Sbjct: 250 R 250 >UniRef50_A0LP75 Silent information regulator protein Sir2 n=3 Tax=Bacteria RepID=A0LP75_SYNFM Length = 244 Score = 267 bits (683), Expect = 2e-70, Method: Composition-based stats. Identities = 95/229 (41%), Positives = 133/229 (58%), Gaps = 6/229 (2%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 V+VLTGAGISAESG+ TFR GLW +R D+ATPE F+ DP+LV FY RR+ L Sbjct: 20 AENVVVLTGAGISAESGVPTFRGEGGLWRTYRATDLATPEAFENDPKLVWEFYGWRRQLL 79 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG 122 + PN H ALA+L+ + F L+TQNID LH++AG+ N++ +HG L VRC++ G Sbjct: 80 APLD--PNPGHYALAELERRIPR-FTLITQNIDGLHQKAGSANILELHGNLWWVRCTRCG 136 Query: 123 QVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMADIFIAIGTSG 180 + + V + C LRPHVVWFGEM +D+ Y A+ + + +GTSG Sbjct: 137 SLTEDRT-VPLPELPRCGSCRGLLRPHVVWFGEMLEPKILDQAYEAIRDCGVMLVVGTSG 195 Query: 181 HVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFV 229 V PAA A+ GA E+NL+P+ + G A +++P + Sbjct: 196 TVQPAASMGVIARKQGATVAEVNLDPTPYSGAYDISISGKAGEILPRLL 244 >UniRef50_A8MBU4 NAD-dependent deacetylase n=14 Tax=cellular organisms RepID=NPD_CALMQ Length = 257 Score = 267 bits (682), Expect = 3e-70, Method: Composition-based stats. Identities = 80/242 (33%), Positives = 120/242 (49%), Gaps = 8/242 (3%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 + TGAGIS ESGI FR GLW +A+ + + DP+ FY R R L Sbjct: 20 SRHAIAFTGAGISTESGIPDFRGPQGLWRRFDPA-LASIDYLNTDPKGFWEFYIERFRVL 78 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG 122 +PN AHLALA+L+ LG ++TQNIDNLH+ AG+ NVI +HG V C + Sbjct: 79 --NNARPNKAHLALAELE-KLGIIKYVITQNIDNLHQSAGSINVIELHGNYTTVYCMRCK 135 Query: 123 QVLDW----TGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGT 178 + E+ C + LRP+VV FGE ++ +++D+ + +G+ Sbjct: 136 TQYPFTLALRKYEEGENPPRCPKCGGILRPNVVLFGEPVNEINRALEIAALSDVALVVGS 195 Query: 179 SGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKGLKA 238 S VYPAA K HG + +NLEP+ + + AS+ + + ++ + A Sbjct: 196 SLTVYPAAYVPLVVKEHGGRLIIINLEPTDYDDYADVVLHCSASEALDLVLNEVKGIMAA 255 Query: 239 GS 240 G+ Sbjct: 256 GN 257 >UniRef50_Q9CM50 NAD-dependent deacetylase n=5 Tax=Proteobacteria RepID=NPD_PASMU Length = 234 Score = 263 bits (672), Expect = 4e-69, Method: Composition-based stats. Identities = 152/229 (66%), Positives = 184/229 (80%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQ 64 R++VLTGAGISAESGIRTFRA DGLWE H V++VATPEGF R+P+LVQ FYN RR+QL Sbjct: 6 RIVVLTGAGISAESGIRTFRATDGLWENHPVDEVATPEGFARNPKLVQRFYNERRKQLFS 65 Query: 65 PEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQV 124 +I PNAAH ALA+L+ LGD L+VTQN+DNLHERAG+ N+IHMHGELLKVRC +SG++ Sbjct: 66 DQIAPNAAHFALAELEKKLGDNLLIVTQNVDNLHERAGSKNLIHMHGELLKVRCVKSGKI 125 Query: 125 LDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGHVYP 184 DW GD+ DKC CC LRPH+VWFGEMPL M++I ALS D FI+IGTSG+VYP Sbjct: 126 YDWQGDIGEHDKCLCCTPTQILRPHIVWFGEMPLEMEKIQTALSECDYFISIGTSGNVYP 185 Query: 185 AAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLL 233 AAGFV EA +GAHTVELNLEPSQV + F E +YG A+++VP ++ + L Sbjct: 186 AAGFVREALFYGAHTVELNLEPSQVRSSFDECHYGKATELVPHYLAQFL 234 >UniRef50_Q8R9N6 NAD-dependent deacetylase 1 n=2 Tax=Thermoanaerobacteraceae RepID=NPD1_THETN Length = 242 Score = 261 bits (667), Expect = 2e-68, Method: Composition-based stats. Identities = 87/232 (37%), Positives = 127/232 (54%), Gaps = 5/232 (2%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 + +VLTGAGIS ESGI TFR DGLW+++ E++ATP F R+P LV +Y+ RRR Sbjct: 12 QSNLTVVLTGAGISKESGIPTFRGEDGLWKKYNPEELATPWAFQRNPALVWEWYDYRRRI 71 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 + + +PN HL +A+ ++ ++TQN+D LHE AG+TNVI +HG + KV+C++ Sbjct: 72 I--SKAKPNKCHLLIAEFEERF-KNVRVITQNVDGLHEAAGSTNVIELHGNIWKVKCTKC 128 Query: 122 GQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMADIFIAIGTS 179 + C + + +RP VVWFGE + E AD+FI IGTS Sbjct: 129 DFRGINREVPLSKIPPECPKCGSIVRPDVVWFGEPLPSDKLTEAMELSQRADLFIVIGTS 188 Query: 180 GHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEK 231 V PAA A GA VE++ E + + + + A + +F EK Sbjct: 189 LMVQPAASLPFLALERGAFVVEVSPEETPLSRKAHLFFQMGAVEFAMKFEEK 240 >UniRef50_UPI00016C4DD0 Silent information regulator protein Sir2 n=1 Tax=Gemmata obscuriglobus UQM 2246 RepID=UPI00016C4DD0 Length = 249 Score = 260 bits (666), Expect = 2e-68, Method: Composition-based stats. Identities = 102/232 (43%), Positives = 141/232 (60%), Gaps = 5/232 (2%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 V VLTGAGISAESG+ TFRA+DGLWE HR+EDVA+P+G+DR+P LV FYNARR + Sbjct: 20 AKSVCVLTGAGISAESGVPTFRASDGLWEGHRIEDVASPDGWDRNPALVWQFYNARRANV 79 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG 122 ++PN H AL L+D GD F LVTQN+D LH +AG+ V+ +HG L + RC+ Sbjct: 80 --ATVKPNPGHFALVALEDRFGDNFKLVTQNVDGLHLQAGSRRVLEIHGSLRQTRCTVCE 137 Query: 123 QVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMADIFIAIGTSG 180 V + + D C Q LRPH+VWFGE E ++ S D + +GTS Sbjct: 138 AVTNRGLE-PLGDAPECPQCHGRLRPHIVWFGEGLPDDIWMEAMVSASECDTLLVVGTSA 196 Query: 181 HVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 V+PAA V A+ GA +E+N+ ++ YGP+ +V+P+ +++L Sbjct: 197 VVHPAASLVPIARRKGATVIEVNITRTEASAYADIGLYGPSGEVLPKLLQRL 248 >UniRef50_A9A3X3 Silent information regulator protein Sir2 n=4 Tax=marine archaeal group 1 RepID=A9A3X3_NITMS Length = 242 Score = 257 bits (657), Expect = 2e-67, Method: Composition-based stats. Identities = 84/237 (35%), Positives = 127/237 (53%), Gaps = 9/237 (3%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 +++ +TGAGIS ESGI TFR DGLW + +AT + F DP+LV +YN RR Sbjct: 13 NAKKIVFVTGAGISQESGIPTFRGKDGLWRNYDAMKLATIDAFYDDPKLVWEWYNERRHN 72 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 + PN H A+A+L+ + +TQNID LH++AG+T V+ +HG ++K++C+ Sbjct: 73 IFS--ANPNQGHKAIAELEKFA--DVVSLTQNIDGLHQKAGSTKVLELHGSIVKIKCTVC 128 Query: 122 GQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMADIFIAIGTS 179 + D T + C+ + LRP VVWFGE E + + D+ I +GTS Sbjct: 129 DFSDEIMTDFT--ENPPLCKCGSILRPDVVWFGESLPQDVWQEAIIHANQCDLMIIVGTS 186 Query: 180 GHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKGL 236 V PA AK + A +E+N E +++ +E ++ +PEFV L K L Sbjct: 187 LVVSPANTLPIYAKQNNAMLIEINPENTEMSSEMDLVIRNTSANALPEFV-SLFKNL 242 >UniRef50_C6A243 NAD-dependent deacetylase n=8 Tax=Euryarchaeota RepID=NPD_THESM Length = 255 Score = 256 bits (655), Expect = 4e-67, Method: Composition-based stats. Identities = 88/243 (36%), Positives = 136/243 (55%), Gaps = 11/243 (4%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 ++ TGAG+SAESGI TFR GLWE +R+E+VATPE F +DP LV +FY R + + Sbjct: 12 SRFLIAFTGAGVSAESGIPTFRDRGGLWENYRIEEVATPEAFRKDPNLVWSFYKMRMKIM 71 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG 122 +PN AHLALA+L+ +G ++TQNIDNLH AGN +++ +HG + +V+C++ Sbjct: 72 --KGAKPNNAHLALAELE-KMGILKAVITQNIDNLHREAGNQHIVELHGNIYRVKCTRCD 128 Query: 123 QVLDWTGDVTPED------KCHCCQFPAPLRPHVVWFGEMPL--GMDEIYMALSMADIFI 174 + + ED C + + LRP VVWFGE + + + AD+ + Sbjct: 129 YMENLLESGKLEDFLKEKNLPKCPECASLLRPDVVWFGEPLPQEALQKAFKLAERADVCL 188 Query: 175 AIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLK 234 +GTS V+PAA + K +G +E+N + S + G A +V+ + K+ + Sbjct: 189 VVGTSAQVFPAAYVPYIVKDNGGSVIEINTKESGITPIADVFIRGKAGEVMQSLLVKVKR 248 Query: 235 GLK 237 L+ Sbjct: 249 CLE 251 >UniRef50_Q72IV5 NAD-dependent deacetylase n=8 Tax=Bacteria RepID=NPD_THET2 Length = 254 Score = 256 bits (655), Expect = 4e-67, Method: Composition-based stats. Identities = 92/233 (39%), Positives = 123/233 (52%), Gaps = 9/233 (3%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 E RV VLTGAGIS SGI TFR A+GLW+ D ATPE + RDPE V A+Y R ++ Sbjct: 13 EAKRVAVLTGAGISKPSGIPTFRDAEGLWKNFNPLDYATPEAYARDPEKVWAWYAWRIQK 72 Query: 62 LQQPEIQPNAAHLALAKLQDAL---GDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRC 118 ++ E +PN AH AL +L+ + G FLLVTQN+D LH RAG+ N++ +HG LL+ RC Sbjct: 73 VR--EAKPNPAHYALVELERRILSRGGSFLLVTQNVDGLHARAGSQNLVELHGNLLRARC 130 Query: 119 SQSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMADIFIAI 176 G+ C RP VVWFGE+ + A + AD + + Sbjct: 131 EACGKRFPLPEAFA--PPPFCPACGHRARPDVVWFGELLPEGAWERAERAFAEADFALVV 188 Query: 177 GTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFV 229 GTS V PAA A GA+ VE+N EP+ + A + + + Sbjct: 189 GTSAEVEPAASLGRIAFASGAYLVEVNPEPTPLTPLAHLSLRTGAVEGMALLL 241 >UniRef50_B1L5P3 NAD-dependent protein deacetylase, SIR2 family n=1 Tax=Candidatus Korarchaeum cryptofilum OPF8 RepID=B1L5P3_KORCO Length = 250 Score = 256 bits (654), Expect = 5e-67, Method: Composition-based stats. Identities = 81/236 (34%), Positives = 124/236 (52%), Gaps = 6/236 (2%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 +V+ TGAGISAE+GI TFR GLWE++ E++ATP+ F RDP+LV +Y R Sbjct: 16 NSGKVVAFTGAGISAEAGIPTFRGKGGLWEKYDPEELATPQAFFRDPKLVWDWYLWRMSI 75 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 + +P AH LA +D G ++TQN+D LH+RAG+ N++ +HG + ++RC+ Sbjct: 76 I--ARARPTPAHEILALWEDK-GILKGVITQNVDGLHQRAGSKNLVELHGSIWRIRCTSC 132 Query: 122 G-QVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPL--GMDEIYMALSMADIFIAIGT 178 +V G++ C + + +RP VVWF E + A + + IGT Sbjct: 133 DNKVYLGFGNLPERVPPECDRCGSIMRPDVVWFYEPLPRDEWMRAEDMIRSASLLLIIGT 192 Query: 179 SGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLK 234 SG V PAA A + A VE+N E + + + + AS++ + E L Sbjct: 193 SGLVMPAATLPMMALRNNATLVEINPEETNLSSLAKFRVREGASRIFVDLNEMLEG 248 >UniRef50_B8KDE3 NAD-dependent deacetylase n=4 Tax=Gammaproteobacteria RepID=B8KDE3_VIBPA Length = 245 Score = 256 bits (654), Expect = 6e-67, Method: Composition-based stats. Identities = 155/237 (65%), Positives = 189/237 (79%) Query: 4 PRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQ 63 V++LTGAGISAESGI+TFRA DGLWE+HR+EDVATPEGF RDP+LVQ FYN RR LQ Sbjct: 6 RNVVILTGAGISAESGIQTFRAQDGLWEDHRIEDVATPEGFARDPDLVQDFYNKRRIMLQ 65 Query: 64 QPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQ 123 +P I+PNAAH+AL +L+ L ++TQNIDNLHER G++NVIHMHGELLK RCS S Q Sbjct: 66 EPHIEPNAAHIALGQLEAELDGTVTVITQNIDNLHERGGSSNVIHMHGELLKARCSVSNQ 125 Query: 124 VLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGHVY 183 V++ G++ D CHCCQ P+ +RPHVVWFGEMPL M EIY +L AD+FI+IGTSG V+ Sbjct: 126 VVEELGEIKTGDLCHCCQMPSQMRPHVVWFGEMPLRMGEIYQSLEDADLFISIGTSGVVF 185 Query: 184 PAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKGLKAGS 240 PAAGFVH+AK+HGAHT+E+NLEPS V +EF EK YG AS VP+ VE++L K + Sbjct: 186 PAAGFVHDAKMHGAHTIEINLEPSAVESEFEEKRYGKASVEVPKLVEEILALQKPQA 242 >UniRef50_Q2LSF2 Sir2 family of NAD+-dependent deacetylase n=2 Tax=Syntrophus aciditrophicus SB RepID=Q2LSF2_SYNAS Length = 271 Score = 255 bits (653), Expect = 6e-67, Method: Composition-based stats. Identities = 74/249 (29%), Positives = 116/249 (46%), Gaps = 14/249 (5%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 RV+V TGAG+S ESGI FR+ GLW+ +D T F R + + + Sbjct: 25 AGRVVVFTGAGVSTESGIPDFRSPGGLWDRFDPDD-FTIGKFLRSAQTRRKQWRILIAGG 83 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELLKVRCSQ 120 E QPN AHLA+A+L+ +G ++TQNIDNLH++AG V +HG + ++C Sbjct: 84 ALAEAQPNRAHLAVAELE-KIGKLNCVITQNIDNLHQKAGNAPEKVYELHGNMRWLKCLS 142 Query: 121 SGQVLDWTGDV------TPEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMADI 172 G + + C + ++P V++FGE + + D+ Sbjct: 143 CGDRVSVPEMFRETALQEMDGFPFCAKCQGLMKPDVIFFGEALPEKTLRDATWQARNCDL 202 Query: 173 FIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 + IG+S VYPAA AK GA V +N + + +E G A +++ ++ + Sbjct: 203 LLVIGSSLVVYPAAYMPMYAKDAGARLVIINRDETPYDSEADVLLQGSAGEIMSRILDAV 262 Query: 233 LK--GLKAG 239 G K G Sbjct: 263 KHRTGFKPG 271 >UniRef50_Q8ZU41 NAD-dependent deacetylase 1 n=4 Tax=Pyrobaculum RepID=NPD1_PYRAE Length = 254 Score = 252 bits (645), Expect = 6e-66, Method: Composition-based stats. Identities = 76/234 (32%), Positives = 113/234 (48%), Gaps = 8/234 (3%) Query: 7 LVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQPE 66 + LTGAG+S SGI FR G+W E F +P+ V + L Sbjct: 24 VALTGAGVSTASGIPDFRGPQGVWRRVDPEK-FEISYFYNNPDEVWD--LFVKYLLPAFN 80 Query: 67 IQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVLD 126 ++PN AH ALA+++ LG ++TQN+D LH+ AG+ NVI +HG L C+ G Sbjct: 81 VKPNPAHYALAEME-RLGKLCAVITQNVDRLHQAAGSKNVIELHGALEYAVCTNCGSKYA 139 Query: 127 WTGDVTPEDK--CHCCQFPAPLRPHVVWFGEMPL--GMDEIYMALSMADIFIAIGTSGHV 182 + C + ++P VV+FGE + E +M MA++F+AIGTS V Sbjct: 140 LAEALKWRKSGAPRCPKCGGVIKPDVVFFGEPLPQDALREAFMLAEMAEVFMAIGTSLAV 199 Query: 183 YPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKGL 236 YPA AK GA V +N + + G A +V+P+ +++L L Sbjct: 200 YPANQLPLVAKKRGAKLVIINADETYYDFFADYIIRGRAEEVLPKLLDRLRGML 253 >UniRef50_Q5L014 NAD-dependent deacetylase 1 n=8 Tax=Firmicutes RepID=NPD1_GEOKA Length = 242 Score = 251 bits (642), Expect = 1e-65, Method: Composition-based stats. Identities = 77/234 (32%), Positives = 111/234 (47%), Gaps = 10/234 (4%) Query: 3 KPRVLVLTGAGISAESGIRTFRAA-DGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 +VLTGAG+S ESG+ FR+ GLW ++AT + E FY R R Sbjct: 10 SRHTVVLTGAGMSTESGLPDFRSPRTGLWARFNPSELATIDALYHRRESFVEFYQYRIRT 69 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 LQ + QP+ H LA + G +VTQN+D H+ AG+ VI +HG L V C + Sbjct: 70 LQ--QCQPHDGHRLLADWERR-GIVQTIVTQNVDGFHQEAGSRRVIELHGSLRTVHCQRC 126 Query: 122 GQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMADIFIAIGTS 179 G+ C+ LRP VV FGE + E + A AD+F+ +G+S Sbjct: 127 GESKP---SFVYLHGVLTCECGGVLRPSVVLFGEPLPEKAITEAWEAAQQADLFLVLGSS 183 Query: 180 GHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYG-PASQVVPEFVEKL 232 V PA AK +GA V +N EP+++ + + +V+ E E+L Sbjct: 184 LQVSPANQLPLVAKRNGAKLVIINWEPTELDDLADAVIHQRKIGEVLNELNEQL 237 >UniRef50_Q2RZG2 Transcriptional regulator, Sir2 family n=2 Tax=Bacteria RepID=Q2RZG2_SALRD Length = 252 Score = 250 bits (640), Expect = 2e-65, Method: Composition-based stats. Identities = 93/243 (38%), Positives = 131/243 (53%), Gaps = 8/243 (3%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 +E V VLTGAGISAESGI TFR GLWEE +++A E F +PELVQ +Y RR Sbjct: 13 VEAGHVAVLTGAGISAESGIPTFRDPGGLWEEFDPQELANVEAFLDNPELVQGWYRHRRE 72 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 ++ + PNA H ALA L+ + +VTQN+D+LH RA + VI +HG + C Sbjct: 73 VVE--DAAPNAGHHALADLEAHVPS-MAVVTQNVDDLHNRAETSTVIELHGNITDNYCMD 129 Query: 121 SGQVLDWTGD---VTPEDKCHCCQFPAPLRPHVVWFGEM--PLGMDEIYMALSMADIFIA 175 Q + + + C +RP VVWFGEM P M++ AD+F++ Sbjct: 130 CEQAVGAAAVDAAIQDGEPARCPDCGGLVRPDVVWFGEMLPPDAMEQADATTEQADVFLS 189 Query: 176 IGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKG 235 +GTS VYPAA A+ GA+ E+N + + V ++ E GPA V+P V+ + Sbjct: 190 VGTSAVVYPAARLPVAAREQGAYVAEVNPDTTGVTDDVHETIRGPAGDVLPALVDAVAAR 249 Query: 236 LKA 238 + Sbjct: 250 QRP 252 >UniRef50_C8QW70 Silent information regulator protein Sir2 n=1 Tax=Desulfurivibrio alkaliphilus AHT2 RepID=C8QW70_9DELT Length = 265 Score = 249 bits (636), Expect = 6e-65, Method: Composition-based stats. Identities = 84/240 (35%), Positives = 120/240 (50%), Gaps = 7/240 (2%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 L LTGAGIS ESGI FR+A GLW + AT E F +DP V R L Sbjct: 15 SRFTLALTGAGISVESGIPDFRSAGGLWARFNPAEYATIEAFRQDPHKVWRMLAEMDRLL 74 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG 122 + +PN AHL LA+L+ LG ++TQN+DNLH+ G+ VI HG + C Sbjct: 75 VRS--RPNPAHLGLAELE-RLGYLQFVITQNVDNLHQAGGSQRVIEFHGNAATLACLACH 131 Query: 123 QVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGE--MPLGMDEIYMALSMADIFIAIGTSG 180 V +V+ + C L+P V++FGE P + + + +S+A + + IGTS Sbjct: 132 AVYSR-AEVSNQAVPPKCVCGQVLKPEVIFFGEEIPPPVLAQAHDLVSLARVLLVIGTSA 190 Query: 181 HVYPAAGFVHEAKLHGAHTVELNLEPSQV-GNEFAEKYYGPASQVVPEFVEKLLKGLKAG 239 V PA+ AK HGA VE+N E +++ G A +++P V +L + G Sbjct: 191 EVAPASMLPRLAKEHGATIVEINPEKTRLTDELTDILLQGRAGEIIPALVAELKRRTTDG 250 >UniRef50_B5Y820 Putative NAD-dependent deacetylase 2 n=1 Tax=Coprothermobacter proteolyticus DSM 5265 RepID=B5Y820_COPPD Length = 245 Score = 248 bits (633), Expect = 1e-64, Method: Composition-based stats. Identities = 69/234 (29%), Positives = 105/234 (44%), Gaps = 10/234 (4%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 +VLTGAGIS ESGI +R GLW ++ + F+ DP+ F Sbjct: 14 NSGHAVVLTGAGISTESGIPDYRGPQGLWRKYDPIKYVSRSTFETDPKTFWEF--NLPMW 71 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 +Q +PN AH +A+L+ LG ++TQNID LH+RAG+ NV +HG L V C + Sbjct: 72 MQYKAAKPNKAHFLVAELE-RLGFIKAVITQNIDGLHKRAGSKNVYEVHGNLETVTCLRC 130 Query: 122 GQVLDWTGDVTPEDKCHC--CQFPAPLRPHVVWFGE-MPLGMDEIYMALSMADIFIAIGT 178 + + C+ C LRP+VV F + MP + + +D+ I +G+ Sbjct: 131 HKEYPLEEAWKQFNDCNIPQCSCGGLLRPNVVLFEDPMPDTFFQAVREVESSDLMIVMGS 190 Query: 179 SGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 S VYP A V +NL P+ + ++ + + L Sbjct: 191 SLEVYPVAQLPAMVS----KLVVVNLLPTPYDDRADYVFHESTGEFSEKLASVL 240 >UniRef50_C9R9I3 Silent information regulator protein Sir2 n=1 Tax=Ammonifex degensii KC4 RepID=C9R9I3_AMMDK Length = 252 Score = 247 bits (630), Expect = 3e-64, Method: Composition-based stats. Identities = 78/245 (31%), Positives = 116/245 (47%), Gaps = 13/245 (5%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEGFDRDPELVQAFYNARR 59 ++ + TGAG+S ESGI FR+ GLW +AT E F DP F+ Sbjct: 14 LKAQKAYAFTGAGVSTESGIPDFRSPGTGLWSNPEALALATGEAFLHDPARFYRFFLPMW 73 Query: 60 RQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCS 119 + + QPN AH ALA+L+ +G +VTQNID LH +AG+ V +HG L + C+ Sbjct: 74 QNYR--RAQPNPAHRALAELE-KMGILRGVVTQNIDGLHRKAGSQVVWEVHGNLENLVCT 130 Query: 120 QSGQVLDW---TGDVTPEDKCHCCQFPAPLRPHVVWFGE-MPLGMDEIYMALSM-ADIFI 174 + + + +D C LRP+VV FGE M + L D+ + Sbjct: 131 RCRRAAPFSLAEEAWAKDDLPPRCGCGGILRPNVVLFGEPMTPDFHRAAIFLRQGCDLLL 190 Query: 175 AIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLK 234 +G+S VYPAA V A+ + +N EP+ + A G A ++P+ VE + Sbjct: 191 VVGSSLTVYPAASLVDYARQ----LIIVNREPTPADDRAAVVLRGQAGIILPKIVEAVKA 246 Query: 235 GLKAG 239 + G Sbjct: 247 HQRLG 251 >UniRef50_B0EU66 NAD-dependent deacetylase, putative n=2 Tax=Entamoeba RepID=B0EU66_ENTDI Length = 344 Score = 247 bits (630), Expect = 3e-64, Method: Composition-based stats. Identities = 72/246 (29%), Positives = 106/246 (43%), Gaps = 13/246 (5%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 + V VLTGAGIS ESGI FR+++GLW+ + + F + PEL + Sbjct: 34 KSKNVTVLTGAGISVESGIPDFRSSNGLWKRYDPSVYGSYSNFKKHPELFWKMTEEIHKI 93 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 PN H ALA+L+ +G +VTQN+D LH++AG+ NV+ MHG C Sbjct: 94 ----TAYPNHVHEALAELE-KIGVVKTIVTQNVDGLHQQAGSKNVVEMHGSGRACYCIDC 148 Query: 122 GQVLDWTGDVTPEDKCH------CCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMADIF 173 + D+ + C + L+ VV FGE DE+ A + D Sbjct: 149 DYISRADNDIWSKPVPPSQCIPRCPKCGGLLKLDVVLFGEKLDRVTYDEVVEASTKTDFL 208 Query: 174 IAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLL 233 + IGTS V P AK GA +N + + G ++VP K+ Sbjct: 209 LVIGTSLQVAPCNIIPFRAKHCGAQVAFINCSKTPMDEYADFVVRGDLKEIVPRIANKIK 268 Query: 234 KGLKAG 239 + + Sbjct: 269 EIREKR 274 >UniRef50_B2A496 Silent information regulator protein Sir2 n=1 Tax=Natranaerobius thermophilus JW/NM-WN-LF RepID=B2A496_NATTJ Length = 252 Score = 246 bits (628), Expect = 5e-64, Method: Composition-based stats. Identities = 74/243 (30%), Positives = 103/243 (42%), Gaps = 14/243 (5%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 + VLTGAGIS ESGI FR DGLW + +T E PE + R + Sbjct: 15 LSSEEPYVLTGAGISTESGIPDFRGKDGLWTKIDPMQYSTREVLMSVPEKFYEYGFERFK 74 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 QL E PN H LA L+ G +VTQNID LH++AG+ V +HG K C Sbjct: 75 QLANKE--PNQGHKILADLEKH-GVISGIVTQNIDGLHQKAGSKQVFEVHGNTRKCYCLG 131 Query: 121 SGQVLDWTG-----DVTPEDKCHCCQFPAPLRPHVVWFGE-MPLGMDEIYMALSM-ADIF 173 Q + + +D C + LRP ++ FG+ MP ++ L D Sbjct: 132 CNQEYPFQELSDQLEKEQKDVPKCKECGGMLRPDIILFGDQMPDLFFKVTTVLKQRCDFL 191 Query: 174 IAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLL 233 + IGTS VYP A G +NLE + + G + + + + + Sbjct: 192 LVIGTSLQVYPVAALAEL----GIPMGIINLEETPFDRQAEVVIQGKCGETLSQLWDHMK 247 Query: 234 KGL 236 L Sbjct: 248 DEL 250 >UniRef50_Q46ZJ9 Silent information regulator protein Sir2 n=4 Tax=Bacteria RepID=Q46ZJ9_RALEJ Length = 260 Score = 245 bits (627), Expect = 7e-64, Method: Composition-based stats. Identities = 90/231 (38%), Positives = 117/231 (50%), Gaps = 10/231 (4%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAA-DGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 + V VLTGAGISAESG+ TFR A GLW E++A+ E + R P LV +Y RR Sbjct: 25 QARSVFVLTGAGISAESGVPTFRDALTGLWARFDPEELASEEAYRRQPALVWEWYQHRRD 84 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 + +PN AH AL L LVTQN+D LH+RAG+ +VI +HG L + Sbjct: 85 LV--AAARPNPAHYALVALAAQ--KTVTLVTQNVDGLHQRAGSDHVIELHGNLFANKWLN 140 Query: 121 -SGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGM--DEIYMALSMADIFIAIG 177 G+ + T P D C A +RP VVWFGE + A AD+ + +G Sbjct: 141 GCGRCDEATA--IPGDPPRCSLCGALMRPGVVWFGEDLPRVARFRAEHAAETADLCLVVG 198 Query: 178 TSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEF 228 TSG VYPAAG A+ HGA V +N +PS + A +P Sbjct: 199 TSGLVYPAAGLPGLARDHGARVVVVNPQPSVLDQTADVVLQAAAGASLPLL 249 >UniRef50_B0VHF0 NAD-dependent deacetylase (Regulatory protein SIR2 homolog) n=1 Tax=Candidatus Cloacamonas acidaminovorans RepID=B0VHF0_9BACT Length = 237 Score = 245 bits (627), Expect = 7e-64, Method: Composition-based stats. Identities = 110/231 (47%), Positives = 135/231 (58%), Gaps = 2/231 (0%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQ 64 VLVLTGAGISAESGIRTFR + GLWE HRVEDVATPE F+ +P V FY R + Sbjct: 9 NVLVLTGAGISAESGIRTFRDSGGLWENHRVEDVATPEAFNSNPVKVWEFYRQRYQDSIS 68 Query: 65 PEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQV 124 +PN AHLAL KL+ LGD FLLVTQN+D LH +AG+ V+ MHG L C++ Sbjct: 69 S--KPNPAHLALVKLEQFLGDNFLLVTQNVDCLHIKAGSKRVLEMHGSLANCICTKCHSK 126 Query: 125 LDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGHVYP 184 L + C LRP +VWFGE+P ++ I AL +FI +GTSG VYP Sbjct: 127 LAIKDIDLTQPIPLCPFCNGILRPDIVWFGEIPHYLNIIDDALRKCSVFIIVGTSGVVYP 186 Query: 185 AAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKG 235 AAGFV AKL GA T+ +NL E Y G + ++P V + Sbjct: 187 AAGFVLTAKLMGAKTIAINLGKPDNLAYIDEFYQGKSGDILPGLVAMWIGE 237 >UniRef50_C1XSL0 NAD-dependent protein deacetylase, SIR2 family n=1 Tax=Meiothermus silvanus DSM 9946 RepID=C1XSL0_9DEIN Length = 265 Score = 245 bits (627), Expect = 8e-64, Method: Composition-based stats. Identities = 86/247 (34%), Positives = 120/247 (48%), Gaps = 21/247 (8%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 E RV VLTGAGISA SGI TFR A GLW++ R+ED ATPE + RDP V +Y R Sbjct: 12 EAKRVAVLTGAGISAPSGIPTFRDAGGLWKDFRIEDYATPEAYRRDPLKVWEWYAWR--Y 69 Query: 62 LQQPEIQPNAAHLALAKLQD-----------------ALGDRFLLVTQNIDNLHERAGNT 104 + QPN AH LA+L+ G FLLVTQN+D LH RAG+T Sbjct: 70 ANAMQAQPNRAHRLLAELERQFTTPSPHVGDRLTPTAREGSGFLLVTQNVDGLHARAGST 129 Query: 105 NVIHMHGELLKVRCSQSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPL--GMDE 162 +++ +HG + + RC + G C + RP VVWFGE+ + Sbjct: 130 HLVELHGSIGRARCEECGARFPLPDPGLFIPPPVCPKCGGRGRPDVVWFGELLPPGAFER 189 Query: 163 IYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPAS 222 A + A++ + +GTS + PAA A GA+ +E+N + + A Sbjct: 190 AENAFAKAEVALVVGTSAEIEPAASLGRLASWAGAYLIEINPNQTPLSRLADCSLRMGAI 249 Query: 223 QVVPEFV 229 + + + Sbjct: 250 EGLEALL 256 >UniRef50_A6LP94 Silent information regulator protein Sir2 n=1 Tax=Thermosipho melanesiensis BI429 RepID=A6LP94_THEM4 Length = 234 Score = 245 bits (627), Expect = 8e-64, Method: Composition-based stats. Identities = 68/237 (28%), Positives = 118/237 (49%), Gaps = 13/237 (5%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 +E+ V+ LTGAGIS SGI FR+ DGL++E+ ++ + E F P++ FY ++ Sbjct: 9 LEEGNVVALTGAGISTSSGIPDFRSEDGLYKEYG-YELFSYEFFKNHPDI---FYEYIKK 64 Query: 61 QLQ-QPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCS 119 + + N +H LA+L++ +G ++TQNID+LH +AG+ NVI +HG C Sbjct: 65 EFPKMYKANYNMSHKLLAELEE-MGYLLGVITQNIDDLHNKAGSRNVIELHGNATHFYCE 123 Query: 120 QSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTS 179 + + + + C +RP +V+FGE +D ++ L A+ + +GTS Sbjct: 124 ECERKYSFPKEYI-------CSCGGLIRPDIVFFGEPVNDIDRVFELLDKAETLLVMGTS 176 Query: 180 GHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKGL 236 VYPA+ F K G + +N E +Q N + + + ++ + Sbjct: 177 LQVYPASNFPVYVKERGGILIIVNREETQYDNFADFVLHMNVEEFSKKVLKYFEEEF 233 >UniRef50_Q2YZT2 Putative uncharacterized protein n=1 Tax=uncultured delta proteobacterium RepID=Q2YZT2_9DELT Length = 254 Score = 245 bits (626), Expect = 1e-63, Method: Composition-based stats. Identities = 77/235 (32%), Positives = 115/235 (48%), Gaps = 7/235 (2%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 ++ V+ +TGAGIS ESGI FR+ GLW + A + F RDP V Sbjct: 13 IKSKYVIAMTGAGISVESGIPDFRSPGGLWSRFDPFEYAHIDAFKRDPAKVWKMLLEIDE 72 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 L + +PN AH ALAKL+ A G ++TQNIDN+H+RAG+ NVI HG + C++ Sbjct: 73 VL--NQAKPNRAHYALAKLE-AAGILKAIITQNIDNMHQRAGSKNVIEFHGNAETLTCTK 129 Query: 121 SGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDE--IYMALSMADIFIAIGT 178 + ++T E C+ +RP VV+FGE + + + IGT Sbjct: 130 CKKKFTR-EEITMESIPPLCECKGVIRPDVVFFGETIPAHATRMAGKEVEKCAMILVIGT 188 Query: 179 SGHVYPAAGFVHEAKLHGAHTVELNLEPSQV-GNEFAEKYYGPASQVVPEFVEKL 232 S V PA+ +AK GA VE+NL +++ + A + + V ++ Sbjct: 189 SADVAPASRLPIKAKEGGAIIVEINLRETRLITPIADFRITDKAGDGLMKLVNEV 243 >UniRef50_B7IF48 NAD-dependent deacetylase n=1 Tax=Thermosipho africanus TCF52B RepID=B7IF48_THEAB Length = 235 Score = 244 bits (624), Expect = 2e-63, Method: Composition-based stats. Identities = 67/231 (29%), Positives = 114/231 (49%), Gaps = 10/231 (4%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 ++ ++VLTGAGIS +SGI FR+ DGL++++ E + + F +P + F + Sbjct: 9 IKNGNIVVLTGAGISTKSGIPDFRSKDGLYQKYG-EKIFDLQFFFENPSVFYDF--VYKE 65 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 + + +PN AH+ LAKL+ G ++TQNIDNLH +AG+ NV+ +HG + C++ Sbjct: 66 FPKMYDAKPNFAHIFLAKLE-KNGYINGIITQNIDNLHYKAGSKNVLELHGNATRFYCTK 124 Query: 121 SGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSG 180 G+ T D C+ +RP +V+F E ++E Y + + I +G+S Sbjct: 125 CGKQSKNTFDGYI------CECGGLIRPDIVFFSESVRYLEESYTLIDNSSTLIVVGSSL 178 Query: 181 HVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEK 231 VYPAA AK +N + + + Y + + + Sbjct: 179 QVYPAAYLPIYAKKQNKTLAIINKGKTPLDDYADIIIYDDIVETFEKIAKH 229 >UniRef50_Q8F3Z6 NAD-dependent deacetylase n=4 Tax=Leptospira RepID=NPD_LEPIN Length = 246 Score = 244 bits (622), Expect = 2e-63, Method: Composition-based stats. Identities = 81/235 (34%), Positives = 122/235 (51%), Gaps = 6/235 (2%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 + ++ ++GAGISAESGI TFR ++GLW+ R ED+ATP+ F ++P+LV +Y RR Sbjct: 11 KFQKISAISGAGISAESGIPTFRGSEGLWKNFRAEDLATPQAFSKNPKLVWEWYLWRRNI 70 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 ++ +PN H AL +L+ F L+TQN+D LH +AG+ + +HG + RC Sbjct: 71 IETK--RPNPGHFALVELERIHP-DFFLITQNVDGLHSQAGSKKLTEIHGNIFINRCISC 127 Query: 122 GQVL-DWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMD--EIYMALSMADIFIAIGT 178 GQ + + T C + LRP VVWFGE + D+ + +GT Sbjct: 128 GQESKETISENTTPLPPQCQNCNSFLRPGVVWFGESYDDFKLNLSIQRMKHTDLLLVLGT 187 Query: 179 SGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLL 233 SG V AK GA +E+N E S + G +V+PE + ++L Sbjct: 188 SGSVSMPVYLAQIAKDSGALLIEINPERSSFSSSVDLFLQGKTGEVLPELIREIL 242 >UniRef50_Q6MJJ2 NAD-dependent deacetylase n=8 Tax=Proteobacteria RepID=NPD_BDEBA Length = 235 Score = 242 bits (618), Expect = 8e-63, Method: Composition-based stats. Identities = 124/231 (53%), Positives = 158/231 (68%), Gaps = 2/231 (0%) Query: 4 PRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQ 63 +++LTGAGISAESGIRTFR DGLWE+HR+EDVATPE F R+P LVQ FYN RR QL+ Sbjct: 7 KNIVILTGAGISAESGIRTFRDQDGLWEDHRIEDVATPEAFARNPALVQRFYNLRRAQLR 66 Query: 64 QPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQ 123 P + PN AH AL L++ FLLVTQN+DNLH RAG+ N++HMHG L +V C + Sbjct: 67 DPNLAPNPAHQALVDLENLWEGNFLLVTQNVDNLHRRAGSKNLLHMHGRLDRVFCLHCDE 126 Query: 124 VLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGHVY 183 +W D+ + C C +RP +VWFGEMP M+EIY AL AD FI+IGTSG+VY Sbjct: 127 HFEWLLDLAVDQPCPHCGRKGGVRPDIVWFGEMPHHMEEIYEALDKADYFISIGTSGNVY 186 Query: 184 PAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLK 234 PAAGFV A A +E+NL+ +++ F E + GPAS VP F+ + L+ Sbjct: 187 PAAGFVRLAWK--AKKIEINLKDTEISPAFDEHFVGPASTEVPRFITQFLE 235 >UniRef50_Q9WYW0 NAD-dependent deacetylase n=5 Tax=Thermotogaceae RepID=NPD_THEMA Length = 246 Score = 242 bits (617), Expect = 9e-63, Method: Composition-based stats. Identities = 71/235 (30%), Positives = 112/235 (47%), Gaps = 9/235 (3%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 E + LTGAGIS SGI FR +G+++++ ++V + F PE F A+ Sbjct: 12 ESRLTVTLTGAGISTPSGIPDFRGPNGIYKKYS-QNVFDIDFFYSHPEEFYRF--AKEGI 68 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 + +PN AH+ LAKL++ G ++TQNID LH+RAG+ VI +HG + + C + Sbjct: 69 FPMLQAKPNLAHVLLAKLEEK-GLIEAVITQNIDRLHQRAGSKKVIELHGNVEEYYCVRC 127 Query: 122 GQVL---DWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPL--GMDEIYMALSMADIFIAI 176 + D + D C + +RP++V+FGE + E S A + I + Sbjct: 128 EKKYTVEDVIKKLESSDVPLCDDCNSLIRPNIVFFGENLPQDALREAIGLSSRASLMIVL 187 Query: 177 GTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEK 231 G+S VYPAA G V +NL + + KY + +E+ Sbjct: 188 GSSLVVYPAAELPLITVRSGGKLVIVNLGETPFDDIATLKYNMDVVEFARRVMEE 242 >UniRef50_Q81BT4 NAD-dependent deacetylase n=75 Tax=Bacillus RepID=NPD_BACCR Length = 245 Score = 242 bits (617), Expect = 1e-62, Method: Composition-based stats. Identities = 68/228 (29%), Positives = 104/228 (45%), Gaps = 3/228 (1%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 + ++ VLTGAG S ESGI FR+A+GL+ + VE + ++R P+ Y + Sbjct: 16 KAKKITVLTGAGASTESGIPDFRSANGLYADANVEMYLSRGYYNRSPKEFWKHYKEIFQI 75 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 + +PN H LA+L++ G ++TQNID LH+ G+ +VI +HG L C + Sbjct: 76 NTFHQYKPNRGHRFLAELEEQ-GKDITILTQNIDGLHQLGGSKHVIDLHGTLQTAHCPKC 134 Query: 122 GQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGH 181 D + + C + L P VV +G+ L D+ I +GTS Sbjct: 135 KSGYDL-QYMIDHEVPRCEKCNFILNPDVVLYGDTLPQYQNAIKRLYETDVLIVMGTSLK 193 Query: 182 VYPAAGFVHEAKLH-GAHTVELNLEPSQVGNEFAEKYYGPASQVVPEF 228 V P A F AK GA T+ +N E + F + + V Sbjct: 194 VQPVASFPQIAKREVGATTILVNEELTGQEYNFDFVFQNKIGEFVEGL 241 >UniRef50_B0SCR8 NAD-dependent protein deacetylase, SIR2 family n=2 Tax=Leptospira biflexa serovar Patoc RepID=B0SCR8_LEPBA Length = 251 Score = 240 bits (614), Expect = 2e-62, Method: Composition-based stats. Identities = 81/237 (34%), Positives = 125/237 (52%), Gaps = 6/237 (2%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 P ++ LTGAGIS+ESGI TFR GLW+ R ED+ATPE F ++P+LV +Y+ RR Sbjct: 14 NAPSIVFLTGAGISSESGIPTFRGEGGLWKNFRAEDLATPEAFQKNPKLVWEWYDWRREI 73 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 Q + +PN HL +AK Q L+TQN+D LH RAG+ +I +HG + +VRC+ Sbjct: 74 CQ--KAKPNLGHLIIAKWQKKSSSV-HLITQNVDGLHPRAGSETLIELHGNIFRVRCTNC 130 Query: 122 GQVLDWTGDVTPEDKCHCCQ-FPAPLRPHVVWFGEMPLG--MDEIYMALSMADIFIAIGT 178 + D C+ + LRP +VWFGE + + + + + I IGT Sbjct: 131 TSIFHLEKDGLDHPGLKFCKECDSLLRPDIVWFGEEYNQNLLTKSWELCKQSQVVILIGT 190 Query: 179 SGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKG 235 S +V A +GA +E+N E + + + G + +V+P+ +++ Sbjct: 191 SANVSVPTNLAQTAIRNGAIGIEINPEETNLTPSMKHHFDGKSGEVLPQIWKEVFPD 247 >UniRef50_A9GVG5 Transcriptional regulatory protein, Sir2 family n=1 Tax=Sorangium cellulosum 'So ce 56' RepID=A9GVG5_SORC5 Length = 269 Score = 240 bits (614), Expect = 2e-62, Method: Composition-based stats. Identities = 97/253 (38%), Positives = 129/253 (50%), Gaps = 26/253 (10%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 ++ VLTGAG+SAESGI TFR A GLW + +A+PE + RDP LV FYN RR Sbjct: 15 RARKIAVLTGAGVSAESGIPTFRGAGGLWRRYEATSLASPEAWRRDPGLVWEFYNHRRE- 73 Query: 62 LQQPEIQPNAAHLALAKLQDAL---GDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRC 118 + PN H ALA+L+ G F L+TQNID LHE+AG+ + + +HG L +VRC Sbjct: 74 -RALGCAPNPGHHALAQLEARWREAGRAFTLITQNIDGLHEKAGSRSPVRLHGSLWQVRC 132 Query: 119 SQSGQV-------------------LDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLG 159 G V + + C LRPHVVWFGE Sbjct: 133 LSCGSVTENRDVPITPAFAGSGSPDPEAPARRFTAAELPRCGCGGVLRPHVVWFGEALQE 192 Query: 160 MDEIYMA--LSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKY 217 D A + D+ + +GTS VYPAAGFV AK HGA E+N+EPS + + Sbjct: 193 SDLAAAAAGVEGCDLLLVVGTSAVVYPAAGFVPMAKRHGALIAEVNVEPSAISGLCDVVF 252 Query: 218 YGPASQVVPEFVE 230 G + ++P ++ Sbjct: 253 TGGSGAILPSLLD 265 >UniRef50_P66814 NAD-dependent deacetylase n=12 Tax=Mycobacterium tuberculosis complex RepID=NPD_MYCBO Length = 237 Score = 239 bits (611), Expect = 5e-62, Method: Composition-based stats. Identities = 86/240 (35%), Positives = 123/240 (51%), Gaps = 11/240 (4%) Query: 5 RVLVLTGAGISAESGIRTFRA-ADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQ 63 RV VL+GAGISAESG+ TFR +GLW ++++ +G+ R+PE V +Y R Sbjct: 2 RVAVLSGAGISAESGVPTFRDDKNGLWARFDPYELSSTQGWLRNPERVWGWYLWRH--YL 59 Query: 64 QPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQ 123 ++PN H A+A QD ++TQN+D+LHERAG+ V H+HG L + RC++ G Sbjct: 60 VANVEPNDGHRAIAAWQDHA--EVSVITQNVDDLHERAGSGAVHHLHGSLFEFRCARCGV 117 Query: 124 VL----DWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMADIFIAIG 177 + E + C +RP +VWFGE A AD+ + +G Sbjct: 118 PYTDALPEMPEPAIEVEPPVCDCGGLIRPDIVWFGEPLPEEPWRSAVEATGSADVMVVVG 177 Query: 178 TSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKGLK 237 TS VYPAAG A G +E+N EP+ + ASQ +P +E+L LK Sbjct: 178 TSAIVYPAAGLPDLALARGTAVIEVNPEPTPLSGSATISIRESASQALPGLLERLPALLK 237 >UniRef50_Q1QDL3 Silent information regulator protein Sir2 n=6 Tax=Bacteria RepID=Q1QDL3_PSYCK Length = 266 Score = 239 bits (610), Expect = 7e-62, Method: Composition-based stats. Identities = 96/247 (38%), Positives = 131/247 (53%), Gaps = 20/247 (8%) Query: 1 MEKP-RVLVLTGAGISAESGIRTFRA-ADGLWEEHRVEDVATPEGFDRDPELVQAFYNAR 58 +E + +LTGAGISAESGI TFR GLWE +R ED+ATP+ F RDP+LV ++Y R Sbjct: 20 LESKQHICLLTGAGISAESGIPTFRDKQTGLWENYRAEDLATPDAFARDPKLVWSWYQWR 79 Query: 59 RRQLQQPEIQPNAAHLALAKLQ---DALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLK 115 R+ + +PN AH ALA+ Q + + L+TQN+D+LHE+AG+ V H+HG L + Sbjct: 80 RQLVASK--KPNPAHTALAQWQYHSQSTNQQLTLITQNVDDLHEQAGSA-VTHLHGNLWR 136 Query: 116 VRCSQSGQVLDWT---------GDVTPEDKCHCCQFPAPLRPHVVWFGEMPL--GMDEIY 164 RCSQ E C +RP +VWFGE Sbjct: 137 NRCSQCQTPYTIQLKSAYDSENSISFDEALMTCQHCDGYIRPDIVWFGESLPMRAWQTAE 196 Query: 165 MALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQV 224 A + D+FI+IGTS VYPAAG AK +GA +E+N P+ A + Sbjct: 197 EAAANCDVFISIGTSSLVYPAAGLAQLAKHNGAKIIEINPYPTP-NTLVDITLAAKAGAI 255 Query: 225 VPEFVEK 231 +PE V++ Sbjct: 256 LPELVKR 262 >UniRef50_A4J646 Silent information regulator protein Sir2 n=2 Tax=Peptococcaceae RepID=A4J646_DESRM Length = 256 Score = 239 bits (609), Expect = 9e-62, Method: Composition-based stats. Identities = 76/240 (31%), Positives = 116/240 (48%), Gaps = 14/240 (5%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 + + + LTGAGIS ESGI FR+ + GLW ++ ++VA+ + ++PE +FY + Sbjct: 16 KAGKTIALTGAGISTESGIPDFRSKNTGLWNQYDPQEVASIQALKKNPE---SFYALNFQ 72 Query: 61 QLQQ-PEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCS 119 + +PN AH ALA+L+ +G ++TQNID LH+ AG+ V +HG L C Sbjct: 73 WWDVCLKAKPNNAHFALARLE-KMGWLLGVITQNIDGLHQHAGSKRVWEVHGNLKGCSCL 131 Query: 120 QSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGE-MPLGMDEIYMALSMADIFIAIGT 178 + D + C LRP VV FG+ MP +S + + IG+ Sbjct: 132 SCKKQFDMGQ---LHKQLRCPFCGGLLRPDVVLFGDAMPEDFFMAEKVMSGCQLLLVIGS 188 Query: 179 SGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKGLKA 238 S VYP A + TV +N EP+ ++ PASQV+ + V+ L Sbjct: 189 SLQVYPVASLPQLSS----KTVIINKEPTTWDKHSDVVFHEPASQVLCDLVDSLNNLQGP 244 >UniRef50_C1FAB6 Putative nicotinic acid mononucleotide:5, 6-dimethylbenzimidazole(DMB)phosphoribosyltransferase n=1 Tax=Acidobacterium capsulatum ATCC 51196 RepID=C1FAB6_ACIC5 Length = 250 Score = 238 bits (608), Expect = 1e-61, Method: Composition-based stats. Identities = 110/230 (47%), Positives = 143/230 (62%), Gaps = 3/230 (1%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 R+ VLTGAGISAESG+ TFR +DGLW +RVE+VATPEG+ +PELV FY+ RRR Sbjct: 13 SDRLFVLTGAGISAESGLATFRGSDGLWNGYRVEEVATPEGWAENPELVWRFYSMRRR-- 70 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG 122 +PNAAH+ALA+L++ +G+RF L TQN+D+LHERAG+ V HMHG L RC + Sbjct: 71 DALAAEPNAAHVALARLEERMGERFYLCTQNVDDLHERAGSRRVHHMHGTLFCSRCVRCQ 130 Query: 123 QVL-DWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGH 181 Q D T + C + + +RPH+VWFGE+P MD IY L A + + +GTSG Sbjct: 131 QPFADARFYETAGELPVCERCGSAVRPHIVWFGEIPRDMDGIYRELEQATVLLVVGTSGS 190 Query: 182 VYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEK 231 VYPAAG V A+ G TV + E F E G A +V+P + Sbjct: 191 VYPAAGLVQVARQRGIATVYVGPERPLNAQAFGEIRLGTAVEVLPGLFGE 240 >UniRef50_B5YJW3 NAD-dependent deacetylase n=1 Tax=Thermodesulfovibrio yellowstonii DSM 11347 RepID=NPD_THEYD Length = 256 Score = 238 bits (608), Expect = 1e-61, Method: Composition-based stats. Identities = 70/241 (29%), Positives = 110/241 (45%), Gaps = 11/241 (4%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 + + TGAGIS ESGI FR+ +GLW+ R + T + F D + F+ +R Sbjct: 18 KSTYSVAFTGAGISTESGIPDFRSPNGLWQRFR---IVTYQEFIIDRKARNEFWKMKREL 74 Query: 62 LQQP-EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 +Q+ +PN AH ALA+L+ G ++TQNID LH+ AGN +VI +HG C Sbjct: 75 IQEIINAKPNNAHNALAELEKR-GLLKYVITQNIDGLHQMAGNKSVIELHGNQRGYICLD 133 Query: 121 SGQVLDWTGDVTPED----KCHCCQFPAPLRPHVVWFGEMPLGMDE--IYMALSMADIFI 174 +V + C ++P +V+FGE + + DI Sbjct: 134 CEKVYPLEEVLKMLKEQELDLRCEVCGGIIKPTIVFFGEPMPEKELLMAQQIANKCDIMF 193 Query: 175 AIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLK 234 IGTS V PAA A +GA + +N ++ +Y A +V+ + ++ + Sbjct: 194 VIGTSLQVEPAASIPRIAYQNGAKLIFINKVQTEWDWIAEIIFYDSAGKVLKDILDVIKS 253 Query: 235 G 235 Sbjct: 254 E 254 >UniRef50_D2R126 Silent information regulator protein Sir2 n=1 Tax=Pirellula staleyi DSM 6068 RepID=D2R126_9PLAN Length = 256 Score = 238 bits (607), Expect = 2e-61, Method: Composition-based stats. Identities = 91/239 (38%), Positives = 129/239 (53%), Gaps = 8/239 (3%) Query: 3 KPRVLVLTGAGISAESGIRTFRAA-DGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 R++VLTGAGISAESG+ TFR A GLW R E++ATPE F+++P+LV +Y RR+ Sbjct: 21 AKRLVVLTGAGISAESGLATFRDAMTGLWANFRAEELATPEAFEQNPKLVWDWYVWRRKL 80 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 Q +PN AH AL +L+ + +VTQN+D LH+RAG+ VI +HG L + +CS Sbjct: 81 AQA--AKPNGAHFALVELERLVPQL-TIVTQNVDGLHQRAGSAGVIELHGSLSRFKCSTD 137 Query: 122 GQVLDWTG--DVTPEDKCHCCQFPAPLRPHVVWFGEMPL--GMDEIYMALSMADIFIAIG 177 + +D D C + A +RP +VWFGEM + + D+F +IG Sbjct: 138 NEPVDAKDFGDSPDGMPPRCPRCHAFVRPDIVWFGEMLPPSALQTAFQVTKKCDLFFSIG 197 Query: 178 TSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKGL 236 TSG V PAA A +GA + NL+ G A ++PE + + L Sbjct: 198 TSGVVEPAASLPRRAIEYGASVMINNLDVDTASEPPLYSLQGKAGTILPELLRRAWPRL 256 >UniRef50_B1I1N5 Silent information regulator protein Sir2 n=1 Tax=Candidatus Desulforudis audaxviator MP104C RepID=B1I1N5_DESAP Length = 249 Score = 237 bits (604), Expect = 3e-61, Method: Composition-based stats. Identities = 74/236 (31%), Positives = 107/236 (45%), Gaps = 13/236 (5%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 E R L LTGAGIS SGI FR+ G WE+ +V++ + F RDP + + Sbjct: 18 ESARTLALTGAGISTASGIPDFRSRGVGRWEKVDPMEVSSVQAFQRDPAAFWRY--NLKW 75 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 L+ + +PN AH LA L+ ++TQN+D LH RAG+ +HG L RC Sbjct: 76 WLEFADAEPNPAHHVLATLERRK-LLQGVITQNVDGLHVRAGS-QTWEVHGHLRTCRCLG 133 Query: 121 SGQVLDWT---GDVTPEDKCHCCQFPAPLRPHVVWFGEMP-LGMDEIYMALSMADIFIAI 176 G ++T C A LRP VV FG+M ++ L + I + Sbjct: 134 CGGRYEFTFLVEQFQAGKNPPRCPCGALLRPDVVLFGDMLGDAFEQAVQVLHGCPLLIVV 193 Query: 177 GTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 G+S VYP A A+ V +N +P+ ++ A G QV + +L Sbjct: 194 GSSLQVYPVAALPRLARR----LVIINRDPTPWDDQAALILRGDIVQVFEKLAAEL 245 >UniRef50_B1MER1 NAD-dependent deacetylase (Regulatory protein Sir2 homolog) n=4 Tax=Mycobacterium RepID=B1MER1_MYCA9 Length = 248 Score = 236 bits (603), Expect = 4e-61, Method: Composition-based stats. Identities = 87/222 (39%), Positives = 116/222 (52%), Gaps = 9/222 (4%) Query: 2 EKPRVLVLTGAGISAESGIRTFRA-ADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 + V VLTGAG+SAESG+ TFR GLW ++ +ATPE + DP LV A+Y RR Sbjct: 14 KARSVTVLTGAGMSAESGLPTFRDAQTGLWSKYDPMTLATPESWQEDPGLVWAWYQNRRI 73 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 QL +QPN H ALA+ +VTQN+D+LHERAG++NV H+HG LLK C Sbjct: 74 QLLA--VQPNDGHRALAQWGSH--RDIRIVTQNVDDLHERAGSSNVTHVHGSLLKSHCDT 129 Query: 121 SGQVLDWT--GDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMD--EIYMALSMADIFIAI 176 + T C +RP +VWFGEM ++ D+ + I Sbjct: 130 CRSDFEATVSAPEAERVAPPECGCGGKVRPSIVWFGEMLPEVEFGHAVAHSQNCDLMLLI 189 Query: 177 GTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYY 218 GTSG VYPAAG A GA VE+N + + + + + Sbjct: 190 GTSGIVYPAAGLPQLALSRGATVVEINPQETDLSDRADLVWR 231 >UniRef50_Q8Y015 NAD-dependent deacetylase n=20 Tax=cellular organisms RepID=NPD_RALSO Length = 246 Score = 236 bits (603), Expect = 5e-61, Method: Composition-based stats. Identities = 92/232 (39%), Positives = 121/232 (52%), Gaps = 10/232 (4%) Query: 3 KPRVLVLTGAGISAESGIRTFRAA-DGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 RV+VLTGAG+SAESG+ TFR A GLW ED+AT + P +V +Y RR Sbjct: 21 AERVMVLTGAGVSAESGVPTFRDALTGLWARFNPEDLATEAAYREHPRMVWDWYQERRA- 79 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ- 120 + ++QPN AHLA+A L LVTQN+D LH+RAG+ VI +HG L + Sbjct: 80 -RVSQVQPNPAHLAIAALATR--KTVALVTQNVDGLHQRAGSVGVIELHGNLFANKWLDG 136 Query: 121 SGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMD--EIYMALSMADIFIAIGT 178 G+ T + P C A LRP VVWFGE + A + D+ + +GT Sbjct: 137 CGKCDVATAE--PGRPPRCAACGAMLRPGVVWFGERLPVVANYRAEEAANTCDVCLVVGT 194 Query: 179 SGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVE 230 SG VYPAAG AK HGA + +N EPS + + PA +P + Sbjct: 195 SGMVYPAAGLPGLAKDHGARVIVVNPEPSVLDETADLVIHQPAGVCLPAMLA 246 >UniRef50_C8X5T0 Silent information regulator protein Sir2 n=3 Tax=Desulfovibrionales RepID=C8X5T0_DESRD Length = 254 Score = 235 bits (600), Expect = 1e-60, Method: Composition-based stats. Identities = 73/239 (30%), Positives = 106/239 (44%), Gaps = 8/239 (3%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 + + TGAGIS SGI FR+ GLW + E V + ++P V F Sbjct: 18 DSRCTVAFTGAGISVPSGIPDFRSPGGLWSRYDPEQVCSEWALRKNPVGVWEFLRDALEL 77 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 PN AH+ALA+L+ G ++TQNIDNLH+ AG+ VI HG + C Sbjct: 78 F--DTATPNQAHIALAELEQQ-GLLSAVITQNIDNLHQEAGSQEVIEYHGNCRRYYCHGC 134 Query: 122 GQVLD---WTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPL--GMDEIYMALSMADIFIAI 176 V + C A +RP VV+FGE + AD+ I + Sbjct: 135 AASYPSDQIAAQVRRKIPVLCASCEAVIRPDVVFFGEAIPQEALFRSAALAREADVMIVV 194 Query: 177 GTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKG 235 GTSG V PA E G +E N+ P+ + + ++ G A +++P ++LL Sbjct: 195 GTSGTVAPANIIPQEVAARGGTVIECNIGPTAYADVTSIRFDGAAEEILPLLAQQLLGR 253 >UniRef50_C7FPB6 NAD-dependent protein deacetylase n=4 Tax=environmental samples RepID=C7FPB6_9BACT Length = 247 Score = 234 bits (597), Expect = 2e-60, Method: Composition-based stats. Identities = 80/236 (33%), Positives = 123/236 (52%), Gaps = 6/236 (2%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 RV V++GAGISAESGI TFR + GLWE R E++ATP+ F DPE V +Y R Q Sbjct: 15 RAERVFVVSGAGISAESGIPTFRGSGGLWEGFRAEELATPQAFAADPERVWRWYRWRAEQ 74 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 + PNA H +A + + TQN+D LH RAG+ V+ +HG + +RC+ Sbjct: 75 Y--GDCAPNAGHDTIAAMASRYRRLL-VATQNVDGLHRRAGSPAVVELHGSIADMRCTAC 131 Query: 122 GQVLDWTGDVTPEDKCHCCQ-FPAPLRPHVVWFGE--MPLGMDEIYMALSMADIFIAIGT 178 + + D C +RPH++WFGE P ++ A AD+ + +GT Sbjct: 132 DTLAPFPRGTEDSDPVPRCALCGERMRPHILWFGETYWPGILERAQQAAEEADVCLVVGT 191 Query: 179 SGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLK 234 S V+P A+ GA +++N E +++ GP+ +++PE E++ + Sbjct: 192 SAQVWPPVALALHAQASGAFLIDINPEATELSGRADAHLAGPSGRLLPELWERVGR 247 >UniRef50_C6P8W9 Silent information regulator protein Sir2 n=2 Tax=Clostridia RepID=C6P8W9_CLOTS Length = 251 Score = 234 bits (596), Expect = 3e-60, Method: Composition-based stats. Identities = 70/239 (29%), Positives = 105/239 (43%), Gaps = 15/239 (6%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEGFDRDPELVQAFYNA-RR 59 + + +VLTGAGIS ESGI FR+ GLWE+ + + DP FYN + Sbjct: 17 KSKKTIVLTGAGISTESGIPDFRSPGTGLWEKMDPMEALSTRVLYNDPI---KFYNNGFK 73 Query: 60 RQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCS 119 L + +PN AH LA+L+ G ++TQNIDNLH++AG+ V +HG+ C Sbjct: 74 ILLSMKDAKPNKAHYILAQLEQE-GLISGVITQNIDNLHQKAGSHKVFEVHGQTRTGSCI 132 Query: 120 QSGQVLDWT----GDVTPEDKCHCCQFPAPLRPHVVWFGE-MPLGMDEIYMALSMADIFI 174 G+V+ E C + LRP VV FG+ MP + + +D+ + Sbjct: 133 NCGEVVSIDLLNSKVEKNEIPPKCDKCNGILRPDVVMFGDPMPEDFERAWREAESSDLMV 192 Query: 175 AIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLL 233 IG+S V P K + +N + AS+ + + L Sbjct: 193 VIGSSLTVSPVNFLPGLVKH----LIIINKSETPEDRRADVVIRESASEALSTILAYLK 247 >UniRef50_Q97MB4 NAD-dependent deacetylase n=71 Tax=cellular organisms RepID=NPD_CLOAB Length = 245 Score = 234 bits (596), Expect = 3e-60, Method: Composition-based stats. Identities = 69/236 (29%), Positives = 108/236 (45%), Gaps = 14/236 (5%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWE-----EHRVEDVATPEGFDRDPELVQAFYN 56 E ++ GAG+S ES I FR+ +GL++ + E + + F E FY Sbjct: 16 ESSSIVFFGGAGVSTESNIPDFRSENGLYKTKNNFSYPPEVMLSHTFFKNHTEDFFEFY- 74 Query: 57 ARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKV 116 R ++ + +PNAAH +LAK+++ G +VTQNID LH+ AG+ NV +HG + + Sbjct: 75 --REKMIFKDAKPNAAHYSLAKIEEQ-GKLKAIVTQNIDGLHQLAGSKNVYELHGSIHRN 131 Query: 117 RCSQSGQVLDWTGDVT-PEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMADIF 173 C G+ D + C + ++P VV + E + A+S AD Sbjct: 132 YCMDCGKSFDLEYVIKSETTIPKCDKCGGIVKPDVVLYEEGLDDSIIQNSVKAISEADTL 191 Query: 174 IAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFV 229 I GTS VYPAAG + K G + +N + NE +V+ + Sbjct: 192 IVGGTSLVVYPAAGLIRYFK--GNKLILINKSATAYDNEADLVISDSIGKVLETVI 245 >UniRef50_C6BY08 Silent information regulator protein Sir2 n=1 Tax=Desulfovibrio salexigens DSM 2638 RepID=C6BY08_DESAD Length = 248 Score = 233 bits (595), Expect = 3e-60, Method: Composition-based stats. Identities = 74/234 (31%), Positives = 104/234 (44%), Gaps = 6/234 (2%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 + + LTGAG+S SGI FR+ GLW +H E VA+ DP V F Sbjct: 17 KARCAIALTGAGMSVASGIPDFRSPGGLWSKHDPEKVASIRALQSDPVTVWKFLLEADSM 76 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 L +PNA H LA+L+ G ++TQNID LH+RAG+ NVI HG + C + Sbjct: 77 L--KSAEPNAGHTGLAQLE-KDGFLQGVITQNIDGLHQRAGSVNVIEFHGNCSEFYCMEC 133 Query: 122 GQVLDWTGDVTPEDKC-HCCQFPAPLRPHVVWFGEMPL--GMDEIYMALSMADIFIAIGT 178 + + C Q +RP +V+FGE + +D+ I GT Sbjct: 134 FAPFPAERIESGSELPVRCPQCSGVIRPDLVFFGEQIPSEAYKAAFELADQSDLVIVAGT 193 Query: 179 SGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 SG V PA+ + G +E+N PS + G V+P V+ L Sbjct: 194 SGGVVPASLIPPRIQEAGGLIIEINKAPSAYTSFSDVFIQGAVEDVLPAIVQNL 247 >UniRef50_A6DC77 Silent information regulator protein Sir2 n=1 Tax=Caminibacter mediatlanticus TB-2 RepID=A6DC77_9PROT Length = 243 Score = 233 bits (595), Expect = 4e-60, Method: Composition-based stats. Identities = 70/234 (29%), Positives = 111/234 (47%), Gaps = 5/234 (2%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 + ++ TGAGIS ESGI TFR GLW ++ + + F ++P+ + Sbjct: 13 DSKNLVAFTGAGISVESGIPTFRGPTGLWSKYDP-KILDIDFFIQNPKESWKYIKEIF-Y 70 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 +I+PN AH LA L+ G ++TQNIDNLH++AG+ NVI HG K+ C Sbjct: 71 DYMQDIKPNEAHYFLADLEKK-GILKAVITQNIDNLHQKAGSKNVIEFHGTANKLECLNC 129 Query: 122 GQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPL--GMDEIYMALSMADIFIAIGTS 179 + C + L+P V+F E ++ ADI + IGT+ Sbjct: 130 KSKFNSFEVPLENIPPLCPKCNGVLKPDFVFFKEPIPKEAFEKSIYYSQNADIMLVIGTT 189 Query: 180 GHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLL 233 G + PA+ AK +GA +E+N+EPS N + + + + + ++ L Sbjct: 190 GEIMPASELPLLAKQNGAAIIEINIEPSNYTNSITDIFLKDKATIAAKKLKSLF 243 >UniRef50_A0LG97 Silent information regulator protein Sir2 n=1 Tax=Syntrophobacter fumaroxidans MPOB RepID=A0LG97_SYNFM Length = 248 Score = 233 bits (595), Expect = 4e-60, Method: Composition-based stats. Identities = 80/239 (33%), Positives = 110/239 (46%), Gaps = 7/239 (2%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 + +VLTGAGIS ESGI FR+ DGLW ++ + F +P V Sbjct: 12 LRSRYTVVLTGAGISVESGIPDFRSKDGLWSKYDPAEYGYIGSFRANPAKVWTMLTEMDA 71 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 L+ + +PN AHLALA L+ G LVTQNID+LH+RAG+ NVI HG +RC + Sbjct: 72 VLR--QARPNFAHLALADLEKR-GIVKELVTQNIDSLHQRAGSKNVIEFHGHNRSLRCDR 128 Query: 121 SGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGE--MPLGMDEIYMALSMADIFIAIGT 178 +V V+ C LRP +V+FGE P A D + +GT Sbjct: 129 CQKVYAR-ESVSLATLPPACACGNALRPEIVFFGEDIPPQAYRSALNAAQKCDFMMIVGT 187 Query: 179 SGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNE-FAEKYYGPASQVVPEFVEKLLKGL 236 S V PA+ AK GA +E+N S++ A++ + L G Sbjct: 188 SASVAPASQLPLVAKSRGAFILEINPMDSELTRRTTDLHICERATRAFEAIMAALDGGW 246 >UniRef50_Q1D737 NAD-dependent deacetylase n=1 Tax=Myxococcus xanthus DK 1622 RepID=Q1D737_MYXXD Length = 245 Score = 233 bits (595), Expect = 4e-60, Method: Composition-based stats. Identities = 101/234 (43%), Positives = 132/234 (56%), Gaps = 11/234 (4%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQP 65 +LVLTGAG+SAESG+ TFR GLWE+ VE VA+PEGF +DP LV FY+ RR+ Sbjct: 12 LLVLTGAGVSAESGVPTFRGMSGLWEDQPVEAVASPEGFRKDPALVWRFYSERRK--AAA 69 Query: 66 EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQ-V 124 + PN H AL + LGDRFLL TQN+D LH RAG+ V+ MHG L K RCS+ G+ Sbjct: 70 AVHPNPGHEALVAWERHLGDRFLLATQNVDGLHTRAGSQRVVEMHGNLFKTRCSRCGRPP 129 Query: 125 LDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEM--PLGMDEIYMALSMAD------IFIAI 176 + C LRPH+VWFGE P + I A +F+A Sbjct: 130 FEDATVYPAGAVPECDACGKLLRPHIVWFGEYLDPADIQRIEDFSLRAATSGGRFVFLAA 189 Query: 177 GTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVE 230 GTSG VYPAAG V + + G T +NL+P++ N F + + +V+P + Sbjct: 190 GTSGAVYPAAGIVDQVRKAGGKTWLVNLDPAENSNRFEHRIVDKSGEVLPTLAK 243 >UniRef50_C0GT54 Silent information regulator protein Sir2 n=1 Tax=Desulfonatronospira thiodismutans ASO3-1 RepID=C0GT54_9DELT Length = 249 Score = 233 bits (594), Expect = 4e-60, Method: Composition-based stats. Identities = 76/235 (32%), Positives = 109/235 (46%), Gaps = 8/235 (3%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 +L LTGAGIS SGI FR+ GLW + + VA+ + +P V F + Sbjct: 18 SECMLALTGAGISVASGIPDFRSPGGLWSRYDPQAVASDWALENNPRQVWEFLLEAVGMI 77 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG 122 +PN AH +LA+++D +G ++TQNIDNLH+RAG+ VI HG C + Sbjct: 78 --AAAKPNPAHESLARMED-MGYLKAVITQNIDNLHQRAGSRKVIEFHGGAGTFYCHKCK 134 Query: 123 QVLDWTGDVTPED---KCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMADIFIAIG 177 + + + C Q +RP VV+FGE + E + AD+ + G Sbjct: 135 KKYNQQKALELTRKDIPWLCSQCYGVVRPGVVFFGEQIPEQALQETRRLVLAADLVLVAG 194 Query: 178 TSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 TSG V PA K G +E+NL + N + PA +P VE L Sbjct: 195 TSGDVAPAGTLPRWVKEQGGRVIEVNLGRTSFQNISDIRLDEPAETALPRIVEAL 249 >UniRef50_Q88BY5 NAD-dependent deacetylase n=11 Tax=Pseudomonas RepID=NPD_PSEPK Length = 262 Score = 233 bits (594), Expect = 5e-60, Method: Composition-based stats. Identities = 86/240 (35%), Positives = 125/240 (52%), Gaps = 13/240 (5%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAA-DGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 V+ TGAGISA+SGI TFR GLW +H + + T + F +P LV ++Y RR Sbjct: 13 RSKTVVFFTGAGISADSGIPTFRDKLTGLWAKHDPQRLETADAFRANPTLVWSWYLWRRH 72 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 Q+ + +PN+AHL++ +L DA G +VTQNID+LHERAG++ V+H+HG L+ V+C Sbjct: 73 QV--SQAKPNSAHLSIPQLADA-GWDVSVVTQNIDDLHERAGSSPVVHLHGSLMDVKCFG 129 Query: 121 SGQVLDWTGDVTPED-------KCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMAD 171 + + + D C + LRP VVWF E + D Sbjct: 130 CHRPAELSPDQLAVPLEGQLIEPPRCTRCNGRLRPGVVWFRENLPDNAWRSAVRLVRACD 189 Query: 172 IFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEK 231 + +++GTSG V PAAG A GA + +NLE + GPA V+P ++ Sbjct: 190 LLVSVGTSGVVMPAAGIPDMALAVGATVIHVNLEDVGMDGADEIMLEGPAGVVLPALLQA 249 >UniRef50_A7HL19 Silent information regulator protein Sir2 n=1 Tax=Fervidobacterium nodosum Rt17-B1 RepID=A7HL19_FERNB Length = 244 Score = 232 bits (593), Expect = 6e-60, Method: Composition-based stats. Identities = 66/235 (28%), Positives = 110/235 (46%), Gaps = 9/235 (3%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 VLTGAG+S SGI FR+ +G++ + +++ + F ++P+ F A++ Sbjct: 13 NSKFTTVLTGAGVSVPSGIPDFRSKNGVYSKWG-QEIFDIDLFHQNPDRFYEF--AKQEL 69 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 ++ +++PN H LA L+ L ++TQNIDNLH++AG+ V +HG + C + Sbjct: 70 IKMLDVEPNEIHYLLAYLE-KLNIVKGVITQNIDNLHKKAGSQKVAEIHGNVRTWSCLKC 128 Query: 122 GQVLDWTGDVTP---EDKCHCCQFPAPLRPHVVWFGEMPL--GMDEIYMALSMADIFIAI 176 G+ D D+ C+ +P +V+FGEM + +D+FIA+ Sbjct: 129 GKRYDLFNSQHKEFLIDRNFRCECGGVTKPDIVFFGEMLPLNEYSKAENWAKESDVFIAM 188 Query: 177 GTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEK 231 GTS VYPAA AK GA +N + + + + E Sbjct: 189 GTSLVVYPAAQLPIYAKHSGAKLCIINKNETVLDDYADLVIHIDLIDFAKEVRRH 243 >UniRef50_A7XXV9 Sirtuin 5 n=14 Tax=Eumetazoa RepID=A7XXV9_PIG Length = 310 Score = 232 bits (593), Expect = 6e-60, Method: Composition-based stats. Identities = 92/253 (36%), Positives = 131/253 (51%), Gaps = 29/253 (11%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 + ++V++GAG+SAESGI TFR A G W + + +D+ATP+ F R+P V FY+ RR Sbjct: 49 KAKHIVVISGAGVSAESGIPTFRGAGGYWRKWQAQDLATPQAFARNPSRVWEFYHHRREV 108 Query: 62 LQQPEIQPNAAHLALAKLQDAL---GDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRC 118 +Q PNA HLA+A+ + L G R +++TQNID LH +AG N++ +HG L K RC Sbjct: 109 VQGRA--PNAGHLAIAQCEARLHGQGRRLVVITQNIDELHRKAGTRNLLEIHGSLFKTRC 166 Query: 119 SQSGQV----------------------LDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEM 156 + G V D V +C LRPHVVWFGE Sbjct: 167 TSCGAVAENYKSPICPALSGKGAPEPETQDARIPVEKLPRCEEAGCGGLLRPHVVWFGEN 226 Query: 157 PLG--MDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFA 214 ++E+ L++ D+ + +GTS VYPAA F + G E N+E + N F Sbjct: 227 LDPAILEEVDRELALCDLCLVVGTSSVVYPAALFAPQVSARGVPVAEFNVEATPATNRFR 286 Query: 215 EKYYGPASQVVPE 227 + GP +PE Sbjct: 287 FHFQGPCGTTLPE 299 >UniRef50_O07595 NAD-dependent deacetylase n=5 Tax=Bacillus RepID=NPD_BACSU Length = 247 Score = 232 bits (592), Expect = 8e-60, Method: Composition-based stats. Identities = 72/236 (30%), Positives = 108/236 (45%), Gaps = 11/236 (4%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLW-EEHRVEDVATPEGFDRDPELVQAFYNARRR 60 E R++VLTGAG+S ESGI FR+A G+W E+ + + + F P L + + Sbjct: 10 EAQRIVVLTGAGMSTESGIPDFRSAGGIWTEDASRMEAMSLDYFLSYPRLFWPKFKELFQ 69 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 +PN HL LA+L+ G + + TQNID LH++AG+ +V +HG + C Sbjct: 70 MKMSGSFEPNEGHLLLAELE-KQGKQVDIFTQNIDGLHKKAGSRHVYELHGSIQTAACPA 128 Query: 121 SGQVLDWTGDVTPEDKCHCCQ-------FPAPLRPHVVWFGEMPLGMDEIYMALSMADIF 173 G D + + C L+ VV FG+ + D +Y L AD+ Sbjct: 129 CGARYDLP-HLLEREVPECTAAGNNGDICGTVLKTDVVLFGDAVMHFDTLYEKLDQADLL 187 Query: 174 IAIGTSGHVYPAAGFVHEAKL-HGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEF 228 + IGTS V PA +A L G V +NLEP+ + F + + Sbjct: 188 LVIGTSLEVAPARFVPEDASLIPGMKKVIINLEPTYCDSLFDMVIHQKIGEFARSL 243 >UniRef50_UPI0001757F4E PREDICTED: similar to NAD-dependent deacetylase sirtuin-1 (SIR2alpha) (mSIR2a) (Sir2) (SIR2-like protein 1) n=1 Tax=Tribolium castaneum RepID=UPI0001757F4E Length = 695 Score = 232 bits (591), Expect = 1e-59, Method: Composition-based stats. Identities = 58/252 (23%), Positives = 96/252 (38%), Gaps = 21/252 (8%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEH--------RVEDVATPEGFDRDPELVQAF 54 ++VLTGAG+S GI FR+ DG++ + + F +DP F Sbjct: 211 AQNIIVLTGAGVSVSCGIPDFRSRDGIYVRLAIDFPDLPDPQAMFDISYFSQDPRPFFKF 270 Query: 55 YNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELL 114 R + + P+ H + L++ G TQNID L + A VI HG Sbjct: 271 ----ARDIYPGKFTPSPCHRFIKMLEN-YGKLLRNYTQNIDTLEKVANIEKVIECHGSFA 325 Query: 115 KVRCSQSGQVLD---WTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSM 169 C++ G + V + C + ++P +V+FGE + + + Sbjct: 326 TATCTKCGHKVTADAIREIVLAQQIPLCEKCQGIMKPDIVFFGEGLPDTFHEAMAQDKTE 385 Query: 170 ADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFV 229 D+ + IG+S V P A H + +N EP + F + G +V Sbjct: 386 CDLLLVIGSSLKVRPVALIPSSLPPH-VPQILINREPLPHCH-FDVELLGDCDVIVNHLC 443 Query: 230 EKLLKGLKAGSI 241 L G+ + Sbjct: 444 -HLFGGVWKEGV 454 >UniRef50_Q9NXA8 NAD-dependent deacetylase sirtuin-5 n=37 Tax=Metazoa RepID=SIRT5_HUMAN Length = 310 Score = 232 bits (591), Expect = 1e-59, Method: Composition-based stats. Identities = 87/253 (34%), Positives = 126/253 (49%), Gaps = 29/253 (11%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 + +++++GAG+SAESG+ TFR A G W + + +D+ATP F +P V FY+ RR Sbjct: 49 KAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQDLATPLAFAHNPSRVWEFYHYRREV 108 Query: 62 LQQPEIQPNAAHLALAKLQDALGD---RFLLVTQNIDNLHERAGNTNVIHMHGELLKVRC 118 + E PNA H A+A+ + LG R +++TQNID LH +AG N++ +HG L K RC Sbjct: 109 MGSKE--PNAGHRAIAECETRLGKQGRRVVVITQNIDELHRKAGTKNLLEIHGSLFKTRC 166 Query: 119 SQSG----------------------QVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEM 156 + G D + V +C LRPHVVWFGE Sbjct: 167 TSCGVVAENYKSPICPALSGKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGEN 226 Query: 157 PLG--MDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFA 214 ++E+ L+ D+ + +GTS VYPAA F + G E N E + N F Sbjct: 227 LDPAILEEVDRELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTPATNRFR 286 Query: 215 EKYYGPASQVVPE 227 + GP +PE Sbjct: 287 FHFQGPCGTTLPE 299 >UniRef50_Q8NSM4 NAD-dependent deacetylase n=15 Tax=Corynebacterium RepID=NPD_CORGL Length = 258 Score = 232 bits (591), Expect = 1e-59, Method: Composition-based stats. Identities = 77/240 (32%), Positives = 121/240 (50%), Gaps = 11/240 (4%) Query: 2 EKPRVLVLTGAGISAESGIRTFRA-ADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 E + V TGAG+SA+SG+ T+R GLW + +A+ + + +DPE + A+Y R Sbjct: 19 EARNIEVFTGAGMSADSGLETYRDDKTGLWSNVDPQAMASIDAWRKDPEPMWAWYRWRAG 78 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVT-QNIDNLHERAGNTNVIHMHGELLKVRCS 119 +PNA H A++ + + + +T QNIDNLHERAG+++V H+HG L + RCS Sbjct: 79 V--AARAEPNAGHQAISYWEGSDTVEHVHITTQNIDNLHERAGSSDVTHLHGSLFEYRCS 136 Query: 120 QSGQVLDWTGDVTPED-----KCHCCQFPAPLRPHVVWFGEMPL--GMDEIYMALSMADI 172 + + E C + +RP VVWFGE D ++ AD+ Sbjct: 137 DCATPWEDDKNYPQEPIARLAPPQCEKCGGLIRPGVVWFGENLPVEEWDIAEQRIAEADL 196 Query: 173 FIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 I +GTSG V+PAA A+ G VE++ +++ + A+Q +P + L Sbjct: 197 MIIVGTSGIVHPAAALPQLAQQRGVPIVEISPTRTELSRIADFTWMSTAAQALPALMRGL 256 >UniRef50_B3EMB2 Silent information regulator protein Sir2 n=2 Tax=Chlorobiaceae RepID=B3EMB2_CHLPB Length = 230 Score = 231 bits (590), Expect = 1e-59, Method: Composition-based stats. Identities = 85/230 (36%), Positives = 129/230 (56%), Gaps = 13/230 (5%) Query: 4 PRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQ 63 ++ TGAG+SAESG+ T+R G+W + +++ A E FDR+PE V F+ RR+ + Sbjct: 11 REIVFFTGAGMSAESGVPTYRGKGGIWGSYSIDEYACQEAFDRNPEKVLGFHEKRRKSVL 70 Query: 64 QPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQ 123 + QP+ H +A L +A +VTQNID +H+RAG+ +VI +HG L ++RC G Sbjct: 71 --DCQPHEGHSVVAVLPNAK-----VVTQNIDGMHQRAGSKDVIELHGSLWRLRCQSCGF 123 Query: 124 VLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMADIFIAIGTSGH 181 + + + C LRP ++WFG+M M + A+ D+F++IGTSG Sbjct: 124 RKEDLAESYETTR---CDCGDRLRPDIIWFGDMLDAVVMSKASQAIRNCDLFVSIGTSGT 180 Query: 182 VYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEK 231 V+PAAGF AK GA+ +E+N EPS G A +V+PE + Sbjct: 181 VWPAAGFPDLAKQSGAYCIEINPEPSGASEY-DRVIVGNAGEVLPELFSE 229 >UniRef50_Q67KQ0 NAD-dependent deacetylase n=1 Tax=Symbiobacterium thermophilum RepID=NPD_SYMTH Length = 251 Score = 230 bits (587), Expect = 3e-59, Method: Composition-based stats. Identities = 68/224 (30%), Positives = 95/224 (42%), Gaps = 9/224 (4%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 + LTGAG S ESG+ FR+ GLW++ + + R P FY R L Sbjct: 15 SRYAVALTGAGASTESGLPDFRSNTGLWKDVDPVSLISMTALRRRPVDFYRFYRMRFSHL 74 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG 122 QPN H LA LQ G L+TQN+D LH+ AG+ +VI +HG L + +C + G Sbjct: 75 W--GAQPNPVHKVLAALQ-REGLLKRLITQNVDGLHQAAGSPDVIELHGSLRECQCLRCG 131 Query: 123 QVLD----WTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALS--MADIFIAI 176 + T D C + L+P VV F E + AD+F+ + Sbjct: 132 RRFPSRLIDVEVETEADIPRCPECGGVLKPGVVLFEEALPADAIEAAIEAAMKADLFLVV 191 Query: 177 GTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGP 220 G+S V PA A HG NL P+ + + Sbjct: 192 GSSLEVGPANQLPVLAVQHGGRLAIFNLTPTFLDPRATWIFREK 235 >UniRef50_C5CGD1 Silent information regulator protein Sir2 n=3 Tax=Thermotogaceae RepID=C5CGD1_KOSOT Length = 249 Score = 230 bits (587), Expect = 3e-59, Method: Composition-based stats. Identities = 71/235 (30%), Positives = 104/235 (44%), Gaps = 8/235 (3%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 E +LTGAG+S SGI FR GL+++ + + + F P R Sbjct: 16 ESESTAILTGAGVSTASGIPDFRGPQGLYKKL-PQYIFDLDFFLSQPAEYYKIAADRIHN 74 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 L E PNA H LA L+ G ++TQNID LH++AG+ VI +HG K C Sbjct: 75 LFNKE--PNATHRLLAMLEKK-GMIEGVITQNIDGLHQKAGSKKVIELHGNAQKFFCMSC 131 Query: 122 GQVLDWTG--DVTPEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMADIFIAIG 177 G+ + C ++P VV+FGE M E Y+ A++FI +G Sbjct: 132 GKRYTAEDVLKMLEVSDVPKCTCGGLIKPDVVFFGEALPESAMAEAYILSENAELFITMG 191 Query: 178 TSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 +S VYPAA AK GA + +N + + +KY ++ + L Sbjct: 192 SSLVVYPAAHLPTFAKQKGAKLLIINQGETGLDYIADKKYECDLAEFSERIISLL 246 >UniRef50_Q96EB6 NAD-dependent deacetylase sirtuin-1 n=36 Tax=Euteleostomi RepID=SIRT1_HUMAN Length = 747 Score = 230 bits (587), Expect = 3e-59, Method: Composition-based stats. Identities = 64/252 (25%), Positives = 99/252 (39%), Gaps = 25/252 (9%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEH--------RVEDVATPEGFDRDPELVQA 53 E +++VLTGAG+S GI FR+ DG++ + + E F +DP Sbjct: 252 ECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFK 311 Query: 54 FYNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGEL 113 F +++ + QP+ H +A L D G TQNID L + AG +I HG Sbjct: 312 F----AKEIYPGQFQPSLCHKFIA-LSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSF 366 Query: 114 LKVRCSQSGQVLDWTG---DVTPEDKCHCCQFP-----APLRPHVVWFGEMPLG-MDEIY 164 C +D D+ + C + P A ++P +V+FGE Sbjct: 367 ATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAM 426 Query: 165 M-ALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQ 223 D+ I IG+S V P A H + +N EP + F + G Sbjct: 427 KYDKDEVDLLIVIGSSLKVRPVALIPSSIP-HEVPQILINREPLPHLH-FDVELLGDCDV 484 Query: 224 VVPEFVEKLLKG 235 ++ E +L Sbjct: 485 IINELCHRLGGE 496 >UniRef50_C6CZ67 Silent information regulator protein Sir2 n=1 Tax=Paenibacillus sp. JDR-2 RepID=C6CZ67_PAESJ Length = 239 Score = 230 bits (587), Expect = 3e-59, Method: Composition-based stats. Identities = 64/236 (27%), Positives = 112/236 (47%), Gaps = 7/236 (2%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEGFDRDPELVQAFYNARR 59 ++ ++ +GAG+S ESG++ FR+AD G+W ++A E D + E FY R Sbjct: 7 LDSSSTIIFSGAGMSTESGLQDFRSADRGMWNNRNPIELADIEAIDSNREEFIRFYQWRI 66 Query: 60 RQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCS 119 ++ QPN H LA ++ G ++TQN++N HE+AG + +HG+L + C Sbjct: 67 HEMNS--HQPNDGHRILADWENR-GLIKGIITQNVENYHEQAGTRQIAKLHGDLGTLHCM 123 Query: 120 QSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPL--GMDEIYMALSMADIFIAIG 177 + + + + +K C +RP+VV FGEM + + ++FI +G Sbjct: 124 KCNKQYE-SKMYLVPEKMTVCSCGGFIRPNVVLFGEMLRQSALQLANKLMKDVELFIVLG 182 Query: 178 TSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLL 233 +S V PA + AK +GA+ V +N +P+ + + + L Sbjct: 183 SSLQVSPANQYPKRAKENGANLVIINNDPTPADHYADIVINNSIGSSLRMIDDLLK 238 >UniRef50_B9L9A0 NAD-dependent deacetylase n=4 Tax=Bacteria RepID=B9L9A0_NAUPA Length = 248 Score = 229 bits (584), Expect = 7e-59, Method: Composition-based stats. Identities = 69/238 (28%), Positives = 107/238 (44%), Gaps = 6/238 (2%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 + + TGAGIS ESGI TFR +GLW ++ + + F +P+ Sbjct: 14 NSKKAVAFTGAGISVESGIPTFRGPNGLWSKYDP-KILDIDYFTLNPKDAWEKIKEIF-Y 71 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 I+PN AH LA L+ ++TQNIDNLH+ AG+ NVI HG + C Sbjct: 72 DYMQNIKPNDAHYFLADLEKEK-MLEAVITQNIDNLHQEAGSKNVIEFHGTAKNLVCMNC 130 Query: 122 GQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPL--GMDEIYMALSMADIFIAIGTS 179 + D + C + L+P+ V+F E +++ D+ + IGT+ Sbjct: 131 FKKYDKDVVDLNDLPPACPKCWGLLKPNFVFFKEPIPKKALEKSLELAQDCDLMLVIGTT 190 Query: 180 GHVYPAAGFVHEAKLHGAHTVELNLEPSQVGN-EFAEKYYGPASQVVPEFVEKLLKGL 236 G + PA+ AK +GA +E+N+EPS N A+ + E+L + Sbjct: 191 GEIQPASQIPILAKENGAKIIEINIEPSNYTNTITDIFLQDKATVASKKLKEELKGAI 248 >UniRef50_A8VRI8 NAD-dependent protein deacetylase SIR2 family-like protein n=1 Tax=Bacillus selenitireducens MLS10 RepID=A8VRI8_9BACI Length = 235 Score = 229 bits (583), Expect = 9e-59, Method: Composition-based stats. Identities = 79/235 (33%), Positives = 119/235 (50%), Gaps = 12/235 (5%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 V+VLTGAG+S ES I FR+ G W++ +ATPE + +PE +AFY AR L Sbjct: 11 ADSVVVLTGAGMSTESNIPDFRSRSGWWQQVDPMTIATPEALEGNPEQFKAFYKARLEAL 70 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG 122 + E +PN H +A+ ++ G + TQN+D LH+RAG+ NV +HG + +RC + Sbjct: 71 E--EAEPNRGHQIIARWEER-GLVDRVATQNVDGLHQRAGSRNVDALHGTIHAIRCHRCD 127 Query: 123 QVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPL--GMDEIYMALSMADIFIAIGTSG 180 + + + E C LRP VV FGEM A+ AD+ + IGTS Sbjct: 128 RPHELDAFLRDE---ACVSCGGVLRPGVVLFGEMLPQDAWQRALKAIEKADVVLVIGTSL 184 Query: 181 HVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKG 235 VYP G TV +N + Q + F + G A +++ E ++L++ Sbjct: 185 DVYPVNQLPSV---TGGKTVYINRDIDQSIHAFDAVHQGSAGEILEEL-DRLMEA 235 >UniRef50_UPI000186E50A snf2 histone linker PHD ring helicase, putative n=2 Tax=Coelomata RepID=UPI000186E50A Length = 1709 Score = 229 bits (583), Expect = 1e-58, Method: Composition-based stats. Identities = 83/239 (34%), Positives = 121/239 (50%), Gaps = 29/239 (12%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 +L+LTGAG+SAESGI TFR G W +++ +++ATPE F +P LV FY+ RR Sbjct: 1472 RSKNLLILTGAGVSAESGIPTFRGPGGYWRKYQAQNLATPEAFRANPSLVWEFYHHRRET 1531 Query: 62 LQQPEIQPNAAHLALAKLQD---ALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRC 118 E PN AH A+A+ Q+ G + ++TQNID LH+RAG ++VI +HG L K RC Sbjct: 1532 ALTKE--PNNAHKAIAECQNRFAKEGKKVWIITQNIDELHKRAGASDVIELHGSLFKTRC 1589 Query: 119 SQSGQVLDWTG----------------------DVTPEDKCHCCQFPAPLRPHVVWFGEM 156 + ++ + +C LRPH+VWFGE Sbjct: 1590 LKCKEIRENYDSPVCSALDGKGAPDPCAESADIPEKLLPRCKKENCGGLLRPHIVWFGEN 1649 Query: 157 --PLGMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEF 213 P ++ A++ D+ + +GTS VYPAA F + G E N+E + +F Sbjct: 1650 LDPKVLELTEKAVNECDLCLVVGTSSVVYPAAMFAPQVAYRGVSVAEFNIESTPATGDF 1708 >UniRef50_Q73KE1 NAD-dependent deacetylase n=2 Tax=Treponema RepID=NPD_TREDE Length = 251 Score = 228 bits (582), Expect = 1e-58, Method: Composition-based stats. Identities = 65/239 (27%), Positives = 107/239 (44%), Gaps = 11/239 (4%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 + ++ TGAGIS +GI+ FR DGL+++ E + + F RDP + +Y + Sbjct: 17 KARHLVAFTGAGISTLAGIKDFRGKDGLYKQPNTEKMFDIDVFYRDPSV---YYGMAKEF 73 Query: 62 LQ-QPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 + E QP H LA L+ G ++TQNID LH++AG+ NVI +HG C Sbjct: 74 IYGLEEKQPAIVHTVLADLEKR-GILKAVITQNIDLLHQKAGSKNVIEVHGSPSVHYCIN 132 Query: 121 SGQVLDWTGDVTPEDK---CHCCQFPAPLRPHVVWFGEMPL--GMDEIYMALSMADIFIA 175 + C + +P++P + +FGE + + S +D + Sbjct: 133 CSYTETFEETAKTAKTGEVPRCPKCGSPIKPAITFFGEALPQKALMKAETEASKSDFMLV 192 Query: 176 IGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLK 234 +GTS VYPAA +G +N +P+Q + + + E ++L K Sbjct: 193 LGTSLLVYPAAALPAYTLRNGGKIAIVNNQPTQFDSYTDLLFE-DLEETFEEIDKRLKK 250 >UniRef50_C4GC77 Putative uncharacterized protein n=3 Tax=Clostridiales RepID=C4GC77_9FIRM Length = 281 Score = 228 bits (581), Expect = 1e-58, Method: Composition-based stats. Identities = 73/254 (28%), Positives = 113/254 (44%), Gaps = 31/254 (12%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWE---EHRVEDVATPEGFDRDPELVQAFY---- 55 +++ GAG+S ESG++ FR+ DGL+ ++ E + + F R PE FY Sbjct: 20 ASKIVFFGGAGVSTESGLKDFRSQDGLYHEHYKYPPERILSHSFFMRQPEDFYRFYFDKL 79 Query: 56 ---------------NARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHER 100 R + I+PNAAH LA+L+ A G ++TQNID LH+R Sbjct: 80 LVDGLAVPKSSGRIGTPARGERSSGVIEPNAAHKKLAELETA-GKLSAVITQNIDGLHQR 138 Query: 101 AGNTNVIHMHGELLKVRCSQSGQVLDWTGDVTPED----KCHCCQFPAPLRPHVVWFGEM 156 AG+ V +HG + + C G D + D HC ++P VV + E Sbjct: 139 AGSRKVFELHGSIHRNHCMSCGHFFDGEYLLAHRDAEKPVPHCPVCGGIIKPDVVLYEEG 198 Query: 157 PLG--MDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFA 214 ++ A+ AD+ I GTS VYPAAGF+ G H V +N + + Sbjct: 199 LDQSVINGALEAIGEADLLIIGGTSLTVYPAAGFIRY--YRGNHLVLINRDATGQDELAD 256 Query: 215 EKYYGPASQVVPEF 228 +G +++ + Sbjct: 257 LVIHGSIGEILGKI 270 >UniRef50_C2AS85 NAD-dependent protein deacetylase, SIR2 family n=1 Tax=Tsukamurella paurometabola DSM 20162 RepID=C2AS85_TSUPA Length = 273 Score = 228 bits (581), Expect = 1e-58, Method: Composition-based stats. Identities = 85/248 (34%), Positives = 118/248 (47%), Gaps = 18/248 (7%) Query: 2 EKPRVLVLTGAGISAESGIRTFRA-ADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 + ++VLTGAG+SAESGI TFR GLW + E++A+ + + RD LV +Y R Sbjct: 26 DAESIVVLTGAGMSAESGIATFREAQTGLWARYDPEEIASVDAWTRDSALVWGWYQWR-- 83 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 + +PN H+ALA+L +VTQNID+LHERAG+ H+HG L RC Sbjct: 84 GYIARQAEPNNGHIALAELGTR--RSVSIVTQNIDDLHERAGSEVTAHLHGSLFAPRCEY 141 Query: 121 SGQVLDWTG-----------DVTPEDKCHCCQFPAPLRPHVVWFGEMPL--GMDEIYMAL 167 G + C Q + +RP +VWFGE A+ Sbjct: 142 CGTPYLGSDAEIRATDGEPTPEMRVTPPTCMQCLSQVRPGIVWFGEPLPMEAWGRAEAAV 201 Query: 168 SMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPE 227 AD+ + IGTSG VYPAA A G VE+N EP+ + + A+ +P Sbjct: 202 IAADLVLVIGTSGLVYPAARLPEMALEAGIPVVEINPEPTPLSARATVAWNTTAATGLPA 261 Query: 228 FVEKLLKG 235 V + G Sbjct: 262 LVAAVTSG 269 >UniRef50_Q899G3 NAD-dependent deacetylase n=52 Tax=Bacteria RepID=NPD_CLOTE Length = 247 Score = 227 bits (580), Expect = 2e-58, Method: Composition-based stats. Identities = 64/238 (26%), Positives = 106/238 (44%), Gaps = 14/238 (5%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWE-----EHRVEDVATPEGFDRDPELVQAFYNA 57 ++ GAG+S ES I FR+ +GL++ + E + + F E FY Sbjct: 14 SSNIVFFGGAGVSTESNIPDFRSEEGLYKTKSNFSYSPEVMLSHSFFKEHTEDFFDFY-- 71 Query: 58 RRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVR 117 + ++ +PN AH ALAKL+ +G ++TQNID LH+ AG+ NVI +HG + + Sbjct: 72 -KEKMIYKYAKPNLAHHALAKLE-KVGKLKAIITQNIDGLHQLAGSKNVIELHGGVGRNY 129 Query: 118 CSQSGQVLDWTGDVTPEDKCHCCQ-FPAPLRPHVVWFGEMP--LGMDEIYMALSMADIFI 174 C + D + ++ C ++P VV + E ++ + +D+ I Sbjct: 130 CMDCNKFFDLNYILNNKEVVPKCDVCGGIVKPDVVLYEEPLNMDNINNAVRYVENSDVLI 189 Query: 175 AIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 GTS VYPAA +H G V +N + + ++ VE+L Sbjct: 190 VGGTSLVVYPAANLIHY--YKGNKLVLINKSSTPYDRKAQIVINDSIGSILGGIVEEL 245 >UniRef50_B1LZ70 Silent information regulator protein Sir2 n=6 Tax=Alphaproteobacteria RepID=B1LZ70_METRJ Length = 237 Score = 227 bits (580), Expect = 2e-58, Method: Composition-based stats. Identities = 111/232 (47%), Positives = 147/232 (63%), Gaps = 5/232 (2%) Query: 4 PRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQ 63 + VLTGAG+SAESG+ TFR G+W +ATPE + DP+ V FY+ RRR + Sbjct: 6 RTIFVLTGAGVSAESGLGTFRDRGGIWARFDPMKLATPEAYAADPDTVLDFYDHRRRGVV 65 Query: 64 QPEIQPNAAHLALAKLQDAL---GDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 +PNAAH ALA+ + + G R L TQN+D+LHERAG+ + HMHGELLK RC Sbjct: 66 A--AEPNAAHRALARAETRIAARGGRLFLCTQNVDDLHERAGSRAITHMHGELLKARCCA 123 Query: 121 SGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSG 180 V W D++ D C C +RP VVWFGEMP+ +D I AL+ AD+F+A+GTSG Sbjct: 124 CTAVTPWRADLSRADSCPACGAAGRMRPDVVWFGEMPMHLDAIEAALAEADLFVAVGTSG 183 Query: 181 HVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 VYPAAG+V +A+ G T E+NLEPS + F + YGPAS +P ++ +L Sbjct: 184 AVYPAAGYVRQARALGIPTCEVNLEPSDNADAFDDARYGPASAALPRYLAEL 235 >UniRef50_UPI0001C3128D Silent information regulator protein Sir2 n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C3128D Length = 256 Score = 227 bits (580), Expect = 2e-58, Method: Composition-based stats. Identities = 70/226 (30%), Positives = 98/226 (43%), Gaps = 10/226 (4%) Query: 3 KPRVLVLTGAGISAESGIRTFRAA-DGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 V+ LTGAGIS SGI FR GLW +VA + + D AFY R + Sbjct: 19 ARSVVALTGAGISVPSGIPDFRTPRTGLWANVDPMEVAHIDAWRNDAARFWAFYGHRFQS 78 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 L+ + +PN AH LA+L+ G ++TQNID LHERAG ++I +HG + C Sbjct: 79 LR--DKRPNRAHEVLAELERR-GIVETVITQNIDQLHERAGVADLIELHGSIAHSSCLAC 135 Query: 122 GQVLDWTGDVTPEDK----CHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMADIFIA 175 G ++ C PL+P VV FGE+ ++ AD+ + Sbjct: 136 GARYPLAEVQARLEQDPQGVPRCDCGRPLKPDVVLFGELLPQAGLERAQTLALRADLLLC 195 Query: 176 IGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPA 221 IG+S VYP G L P++ + K G Sbjct: 196 IGSSLEVYPVGELPSLTLRAGGEIAILTQGPTRYDRDAVVKLDGDI 241 >UniRef50_C7RQR7 Silent information regulator protein Sir2 n=1 Tax=Candidatus Accumulibacter phosphatis clade IIA str. UW-1 RepID=C7RQR7_9PROT Length = 253 Score = 227 bits (579), Expect = 2e-58, Method: Composition-based stats. Identities = 82/236 (34%), Positives = 118/236 (50%), Gaps = 9/236 (3%) Query: 2 EKPRVLVLTGAGISAESGIRTFR-AADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 V+V +GAG+SA+SGI TFR A GLW ++VA+ EGF R P +V + + Sbjct: 15 RAREVVVFSGAGLSADSGIPTFRDGATGLWNNVDPDEVASIEGFLRKPRVVWDWLLQLKN 74 Query: 61 QLQQPEIQPNAAHLALAKLQDA-LGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCS 119 + + PNA H A+A+L+D G R ++TQNID H +AGN V+ +HG + +VRC Sbjct: 75 LV--DDRHPNAGHEAIARLEDLCKGKRLTIITQNIDGYHTQAGNAQVLEVHGTIHRVRCH 132 Query: 120 Q-SGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALS--MADIFIAI 176 + G + + + C P+RP +V FGEM + AD+F + Sbjct: 133 RRCG--FAAVWEQSAVEPFSCPNCGGPVRPDLVLFGEMLDEEVFAAAGIRSLNADLFFCV 190 Query: 177 GTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 GTS V PAA AK GA VE+N P+ + + ASQ +L Sbjct: 191 GTSFTVQPAARLPVWAKGAGATVVEVNPHPTPLSDAADYSIRAGASQFFGALCARL 246 >UniRef50_D2QCS2 Silent information regulator protein Sir2 n=29 Tax=Bacteria RepID=D2QCS2_9SPHI Length = 235 Score = 227 bits (579), Expect = 3e-58, Method: Composition-based stats. Identities = 102/233 (43%), Positives = 141/233 (60%), Gaps = 7/233 (3%) Query: 4 PRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQ 63 +++VL+GAGISAESGI TFRA+DGLWE HR+EDVATPE + R+P LVQ FYN RR+ Q Sbjct: 5 KKIVVLSGAGISAESGIPTFRASDGLWENHRIEDVATPEAWHRNPALVQDFYNQRRK--Q 62 Query: 64 QPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQ 123 +QPNA HLAL KL++ ++TQN+DNLHE+AG++ V+H+HGEL K R + Sbjct: 63 ALSVQPNAGHLALVKLEEKF--DVTVITQNVDNLHEKAGSSKVVHLHGELFKSRSTVDES 120 Query: 124 VLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGHVY 183 ++ +D C + + LRPH+VWFGE MD AD+FI +GTS +VY Sbjct: 121 LIYDIEGWELKDGDVCAK-GSQLRPHIVWFGEAVPMMDIALDITEQADLFIVVGTSLNVY 179 Query: 184 PAAGFVHEAKLHGAHTVELNLEPSQVGNEFAE-KYYGPASQVVPEFVEKLLKG 235 PAAG V A G ++ + + PA+ + + E+L+ Sbjct: 180 PAAGLV-YAVREGVPVYVVDPSIPDMHKKNNVTFIAEPATIGLTQLAEQLIAE 231 >UniRef50_D0WS10 NAD-dependent deacetylase n=2 Tax=Actinomyces RepID=D0WS10_9ACTO Length = 245 Score = 226 bits (577), Expect = 4e-58, Method: Composition-based stats. Identities = 69/238 (28%), Positives = 112/238 (47%), Gaps = 13/238 (5%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHR---VEDVATPEGFDRDPELVQAFYNAR 58 + R++ GAG+S ESGI FR A+G + + R +E V + + F+ P+ ++ Sbjct: 14 QSNRIVFFGGAGVSTESGIPDFRGAEGFFHQDREIPIERVLSIDFFETHPQAYWEWFA-- 71 Query: 59 RRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRC 118 ++ + + PNAAH LA+L+ G +VTQNID LH+ AG+ + +HG ++ C Sbjct: 72 -QENAREGVAPNAAHRFLAELEKR-GSLSAVVTQNIDGLHQSAGSERIFELHGNWSRLLC 129 Query: 119 SQSGQVLDW--TGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMADIFI 174 G+ + C +RP +V++GEM ++ A++ AD+ I Sbjct: 130 MGCGRRFSIADFDEARTGAVPRCPSCACVVRPDIVFYGEMLGSGVLEGAVRAIADADMLI 189 Query: 175 AIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 GTS VYPAAG V G V +N P+ + P +V E + Sbjct: 190 VAGTSLVVYPAAGLVDY--YDGDRLVLMNATPTPYDSRANLVIRDPVGKVFAELARAV 245 >UniRef50_B6KET2 NAD-dependent deacetylase, putative n=3 Tax=Toxoplasma gondii RepID=B6KET2_TOXGO Length = 360 Score = 226 bits (577), Expect = 4e-58, Method: Composition-based stats. Identities = 86/243 (35%), Positives = 123/243 (50%), Gaps = 14/243 (5%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAA-DGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 + V+ LTGAG+SAESGI TFR DGLW+++ AT GF R P + Sbjct: 123 KAKYVVALTGAGVSAESGIPTFRDPSDGLWKKYDPTVYATIWGFWRYPH---KIWELLLD 179 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 L+ + PNAAH+AL LQ LG +VTQN+DNLH+ +G+TNVI HG LL C Q Sbjct: 180 FLRTNDPMPNAAHVALTDLQ-RLGYLKFIVTQNVDNLHQDSGSTNVIEYHGSLLSATCRQ 238 Query: 121 SGQVLDW-----TGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMADIF 173 G+ + + +D C +P V+ FGE + + + D+ Sbjct: 239 CGKKMRLSKSMLQDENFAKDLPPKCACGGIFKPDVILFGEGIPANAVRDANREVDKCDLL 298 Query: 174 IAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNE-FAEKYYGPASQVVPEFVEKL 232 + +GTS V PA+ + A GA VE+NLE + + N + G ASQ + + V+ L Sbjct: 299 LVVGTSASVSPASDLPYRAMRGGAKVVEVNLETTGLTNRISDKFVQGRASQ-LAQTVKAL 357 Query: 233 LKG 235 + Sbjct: 358 QRR 360 >UniRef50_UPI000179269F PREDICTED: similar to sirtuin n=1 Tax=Acyrthosiphon pisum RepID=UPI000179269F Length = 583 Score = 226 bits (577), Expect = 4e-58, Method: Composition-based stats. Identities = 62/246 (25%), Positives = 100/246 (40%), Gaps = 23/246 (9%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEH--------RVEDVATPEGFDRDPELVQAF 54 R++VLTGAG+S GI FR+ +G++ + + + F +DP F Sbjct: 203 SNRIMVLTGAGVSVSCGIPDFRSHNGVYARLATEFPDLPDPQSMFCIDYFSKDPRPFFKF 262 Query: 55 YNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELL 114 R++ + +P+ +H + L+ G TQNID L + G NVI HG Sbjct: 263 ----AREIYPGQFKPSPSHQFIKVLEKK-GRLLRNYTQNIDTLEQVVGINNVIECHGSFA 317 Query: 115 KVRCSQSGQVLD---WTGDVTPEDKCHCCQF---PAPLRPHVVWFGE-MPLGMDEIYM-A 166 C+Q G + DV + C ++P +V+FGE +P + Sbjct: 318 TASCTQCGHKVSAETIRPDVFEQRIPRCPICVNSTGIMKPDIVFFGEGLPDSFHKAIEDD 377 Query: 167 LSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVP 226 + D+ I IG+S V P A + H + +N E N F + G + +V Sbjct: 378 KNNCDLLIVIGSSLKVRPVARIPNMLDKH-VPQILINRERLPHMN-FDVELLGDSDVIVD 435 Query: 227 EFVEKL 232 L Sbjct: 436 HLCRML 441 >UniRef50_A9AWT4 Silent information regulator protein Sir2 n=1 Tax=Herpetosiphon aurantiacus ATCC 23779 RepID=A9AWT4_HERA2 Length = 243 Score = 226 bits (576), Expect = 5e-58, Method: Composition-based stats. Identities = 87/237 (36%), Positives = 131/237 (55%), Gaps = 12/237 (5%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAA--DGLWEEHRVEDVATPEGFDRDPELVQAFYNARR 59 + ++VLTG+GISA SGI T+R+A D W + + VAT GF+RDP V Y A + Sbjct: 14 QTQSLVVLTGSGISAPSGIPTYRSAAADARWTAYDPDKVATFAGFERDPVGVFQVYQAMK 73 Query: 60 RQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCS 119 RQ + QPNA H ALA+L+ LG +F L TQNID+LH+RAG++ V +HG L + CS Sbjct: 74 RQCEA--AQPNAGHYALAQLEQ-LGTQFKLFTQNIDSLHQRAGSSQVYEVHGSLARTICS 130 Query: 120 QSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMADIFIAIG 177 + G +++ ++ C APLRP +VWFGE+ + A +D+ + IG Sbjct: 131 REGNLVETWNA----EQPICPACGAPLRPDIVWFGELLDAGILQAAKAAFDSSDVALVIG 186 Query: 178 TSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLK 234 TS V P A H A +E+N + + G A +++P+ ++++ K Sbjct: 187 TSAIVEPIASLPHRALRRKKTVIEINPDI-PLRGIATFSLAGSADELLPQLIKEVWK 242 >UniRef50_B0S0T6 Transcriptional regulator Sir2 family n=4 Tax=Clostridiales Family XI. Incertae Sedis RepID=B0S0T6_FINM2 Length = 246 Score = 226 bits (576), Expect = 6e-58, Method: Composition-based stats. Identities = 64/238 (26%), Positives = 106/238 (44%), Gaps = 14/238 (5%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEE-----HRVEDVATPEGFDRDPELVQAFYN 56 + +++ GAG+S SGI FR+A GL+ + E + + E F P+L Q + Sbjct: 13 QSDKIVFFGGAGVSTASGIPDFRSATGLYNKKNDSDFSPEYMLSHEFFVTHPDLFQDY-- 70 Query: 57 ARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKV 116 L ++PN AHL+L KL+ ++TQNID+L AG N+ +HG L Sbjct: 71 -VLENLIIDGVKPNNAHLSLRKLE-KANKLLGVITQNIDSLDTMAGTKNIAEIHGNLRDY 128 Query: 117 RCSQSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPL--GMDEIYMALSMADIFI 174 C G D C C + +RP V +GE+P + ++ AD I Sbjct: 129 YCVNCGAKYDL-DYYKQNRPCKCEKCGGVVRPDVTLYGEVPPQSEFAKAINWINKADTMI 187 Query: 175 AIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 G+S VYPA+G ++ G + + +NL+ + N + ++ + + Sbjct: 188 VAGSSLVVYPASGLINYF--RGDNLILINLDRTSYDNMANIVIHDDIAKTLEYVTRDI 243 >UniRef50_Q1RPU3 Zinc finger protein (Fragment) n=1 Tax=Ciona intestinalis RepID=Q1RPU3_CIOIN Length = 737 Score = 226 bits (576), Expect = 6e-58, Method: Composition-based stats. Identities = 61/251 (24%), Positives = 101/251 (40%), Gaps = 24/251 (9%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEH--------RVEDVATPEGFDRDPELVQAF 54 ++LVLTGAG+S GI FR+ DG++ + + F DP F Sbjct: 188 SKKILVLTGAGVSVSCGIPDFRSRDGIYSRLSVDFPDLPNPQAMFDIHYFKHDPRPFFKF 247 Query: 55 YNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELL 114 +++ + +P+ AH ++ L+ G TQNID L + AG + V+ HG Sbjct: 248 ----AKEIYPGQFKPSRAHRFISLLE-KTGRLLRNYTQNIDTLEQVAGISKVVQCHGSFA 302 Query: 115 KVRCSQSGQVLDWTG---DVTPEDKCHCCQFPA----PLRPHVVWFGEMPLGMDE--IYM 165 C + D+ + HC + P+ ++P +V+FGE + Sbjct: 303 TASCCSCDYKTNCEELRADIFNQVVPHCPRCPSDDPGVIKPDIVFFGENLPQQFHRQMTS 362 Query: 166 ALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVV 225 AD+ I IG+S V P A + H + +N EP F + G ++ Sbjct: 363 DKDDADLLIVIGSSLKVRPVALIPNSIPDH-IPQLLINREPLSHM-TFDIELLGDCDVIL 420 Query: 226 PEFVEKLLKGL 236 E ++L Sbjct: 421 SEISKRLGGEF 431 >UniRef50_D1UAS5 Silent information regulator protein Sir2 n=1 Tax=Desulfovibrio aespoeensis Aspo-2 RepID=D1UAS5_9DELT Length = 249 Score = 225 bits (575), Expect = 7e-58, Method: Composition-based stats. Identities = 73/237 (30%), Positives = 100/237 (42%), Gaps = 6/237 (2%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 + TGAGIS ESGI FR G+W +H + F R P+ V Sbjct: 15 NARCAIAFTGAGISVESGIPPFRGPGGVWSKHDPDK-FEKTYFQRHPQEVWPLLKEIF-F 72 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 +PN AHLALAKL++A G ++TQNID LH+ AG+ V HG ++ C Sbjct: 73 DTLGRARPNPAHLALAKLEEA-GRLAAIITQNIDGLHQAAGSKTVYEYHGSTRRMECLDC 131 Query: 122 GQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMADIFIAIGTS 179 G D C L+P V+F E +D+ + +GT Sbjct: 132 GAFFDSASIPLDRLPPPCPACGGLLKPDFVFFSEPIPFEVHQAATNLARQSDVCLIVGTG 191 Query: 180 GHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEF-AEKYYGPASQVVPEFVEKLLKG 235 G V PA HE + G VE+NL ++ F G A +VPE V ++ Sbjct: 192 GEVMPAGRIPHEVRNAGGKVVEINLYETRYSYGFSDVFLQGRAGVLVPELVGMVMGR 248 >UniRef50_C0GF21 Silent information regulator protein Sir2 n=1 Tax=Dethiobacter alkaliphilus AHT 1 RepID=C0GF21_9FIRM Length = 247 Score = 225 bits (573), Expect = 1e-57, Method: Composition-based stats. Identities = 67/236 (28%), Positives = 103/236 (43%), Gaps = 14/236 (5%) Query: 3 KPRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 +VLTGAGIS ESGI FR+ GLWE+ ED T + F RDP + + Sbjct: 17 ANYAVVLTGAGISTESGIPDFRSPGTGLWEKEDPED-FTIDSFQRDPHSFYRRIHPLLKV 75 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 + + +PN H ALA L+ + G L+TQN+D LH++AG+ NV+ +HG C Sbjct: 76 I--DKAEPNPGHTALADLETS-GIIKSLITQNVDGLHQKAGSKNVLEVHGSFQTGTCHDC 132 Query: 122 GQVL---DWTGDVTPEDKCHCCQF-PAPLRPHVVWFG-EMPLGMDEIYMALSMADIFIAI 176 + D +T C ++P V FG EMP + D + + Sbjct: 133 RKKSGLADLNLLLTAGKDPDCPHCGGNTVKPDVTLFGEEMPPDFQLAHREALKCDCMLVV 192 Query: 177 GTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 G+S V P AK + +N + + + QV+ + + ++ Sbjct: 193 GSSLQVAPVGFLPRYAKN----LLIINRGSTPYDDHAQVVIREGSGQVLTDIIAEI 244 >UniRef50_B0EBU9 NAD-dependent deacetylase, putative n=3 Tax=Entamoeba RepID=B0EBU9_ENTDI Length = 362 Score = 225 bits (573), Expect = 1e-57, Method: Composition-based stats. Identities = 66/243 (27%), Positives = 116/243 (47%), Gaps = 10/243 (4%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 V+VLTGAGIS +GI FR+ +G+W+ + + + E F + PE+ + R+ Sbjct: 26 RSKHVVVLTGAGISVSAGIPDFRSRNGMWKRYEPKIYGSYENFIKRPEMFWKMCSELRK- 84 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 +P AH AL KL++ ++TQN+DNLH+ AG+ V +HG +C + Sbjct: 85 -YTEGKKPTKAHFALRKLEEIG-KIEEIITQNVDNLHQLAGSRKVNELHGTGKICQCIKC 142 Query: 122 GQVLDWTGD-----VTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDE--IYMALSMADIFI 174 G + + D C + ++ VV FGE + S++D+F+ Sbjct: 143 GYRGNADVILPKGLIPWIDIPKCPKCGGLIKLDVVLFGEELEKEKFEKAFEVASISDVFL 202 Query: 175 AIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLK 234 IG+S V PA +AK++ A +N ++ N G + ++P+ VE +++ Sbjct: 203 VIGSSLEVMPANALPRKAKMNSATVAYINKTITRFDNYADYVIRGESDYLIPKIVEYVIE 262 Query: 235 GLK 237 ++ Sbjct: 263 FME 265 >UniRef50_C4FX59 Putative uncharacterized protein n=1 Tax=Catonella morbi ATCC 51271 RepID=C4FX59_9FIRM Length = 259 Score = 224 bits (571), Expect = 2e-57, Method: Composition-based stats. Identities = 74/238 (31%), Positives = 114/238 (47%), Gaps = 16/238 (6%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLW-----EEHRVEDVATPEGFDRDPELVQAFYN 56 + ++ GAG+S ESGI FR+A G++ E + + + + P+L FY Sbjct: 24 DSHHLVFFGGAGVSTESGIPDFRSAQGVYSQDLGRNFSAEQLISHSMYQKYPQLFYDFY- 82 Query: 57 ARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKV 116 R+ L P +PNAAH+ LA+L+ A G +++QNID LHE AG+ V+ +HG + + Sbjct: 83 --RKHLIYPHAKPNAAHIFLAQLE-ASGHLDAVISQNIDTLHEAAGSQCVLKLHGTVDRN 139 Query: 117 RCSQSGQVLD---WTGDVTPEDKCHCCQFPAPLRPHVVWFGEMP--LGMDEIYMALSMAD 171 C + G+V D + + C L+P V + E D+ +A+ AD Sbjct: 140 ICQECGRVYDLKSFLDAYDSQGIPRCPHCGGVLKPDVTLYEESLNMEVFDQAILAIQQAD 199 Query: 172 IFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFV 229 I GTS VYPAAG + K G H V +N + + + P QV + V Sbjct: 200 TLIVGGTSLVVYPAAGLLQYFK--GKHLVVINKQAIPQDDWADLVIHAPIGQVFSQLV 255 >UniRef50_B8F955 Silent information regulator protein Sir2 n=1 Tax=Desulfatibacillum alkenivorans AK-01 RepID=B8F955_DESAA Length = 246 Score = 224 bits (571), Expect = 2e-57, Method: Composition-based stats. Identities = 76/233 (32%), Positives = 115/233 (49%), Gaps = 6/233 (2%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 V+ LTGAG+S ESGI FR GLWE+ ++A + F +PE V + Sbjct: 14 NARLVVALTGAGVSVESGIPPFRGKGGLWEKFDPMEIAHIDSFLANPERVWRI-LVAEMK 72 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 + QPN H LA+L++ G+ ++TQN+D LH+ AG+ +VI HG + RC Sbjct: 73 GVIDKAQPNNLHKGLARLEE-TGNLAAIITQNVDGLHQAAGSKDVIEFHGTFAEQRCMDC 131 Query: 122 GQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPL--GMDEIYMALSMADIFIAIGTS 179 + T +V+ E C LRP V+FGEM + D+ + +GTS Sbjct: 132 EAKIP-TSEVSLEVIPPRCSCGGMLRPDCVFFGEMIPSEALWRSKELAEQCDVMMVVGTS 190 Query: 180 GHVYPAAGFVHEAKLHGAHTVELNLEPSQV-GNEFAEKYYGPASQVVPEFVEK 231 V PAA AKL GA +E+N+E + + G +G A +++ +E+ Sbjct: 191 AIVEPAASMARIAKLGGATVIEMNMERTMLTGRVADYSLFGGAGKLMTGILEE 243 >UniRef50_D2RNB5 Silent information regulator protein Sir2 n=1 Tax=Acidaminococcus fermentans DSM 20731 RepID=D2RNB5_ACIFE Length = 257 Score = 224 bits (570), Expect = 2e-57, Method: Composition-based stats. Identities = 73/240 (30%), Positives = 111/240 (46%), Gaps = 16/240 (6%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHR-------VEDVATPEGFDRDPELVQAF 54 E ++ GAG+S SGI FR+ DGL+ +H E + + +P++ F Sbjct: 19 EADHIVFFGGAGVSTASGIPDFRSKDGLYNQHDVRFDQYRPEYLLSHSCLVNEPKVYFEF 78 Query: 55 YNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELL 114 + R+++ +IQPN AH LA L+ G +VTQNID LH++AG+ V +HG L Sbjct: 79 H---RQKMDTRKIQPNNAHKYLAALE-KTGKLDGIVTQNIDGLHQKAGSRKVYEIHGSAL 134 Query: 115 KVRCSQSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMADI 172 + C G+ ++ C +RP + + EM ++ A+S AD+ Sbjct: 135 RNYCMSCGKRYPSDYIFESKEPIPHCTCGGVIRPDITLYEEMLPDEAVENAVRAISRADL 194 Query: 173 FIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEF-AEKYYGPASQVVPEFVEK 231 I GTS VYPAA F++ HG V LN +P V + +V EK Sbjct: 195 MIIAGTSLTVYPAASFINYF--HGKRLVILNRDPLSVHMKAETLVITENMDKVFKALAEK 252 >UniRef50_A5UYK2 Silent information regulator protein Sir2 n=2 Tax=Roseiflexus RepID=A5UYK2_ROSS1 Length = 261 Score = 224 bits (570), Expect = 3e-57, Method: Composition-based stats. Identities = 67/234 (28%), Positives = 99/234 (42%), Gaps = 7/234 (2%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 + +TGAGIS SGI FR DG W+ +VA+ F R+P ++ + Sbjct: 20 RAHSAVAITGAGISTPSGIPDFRGPDGAWKHVDPSEVASLHNFLRNPRAFYDWFRPLLDR 79 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 + AAH ALA L+ ++TQN D LH+RAG+ V +HG L C + Sbjct: 80 VLAAAPN--AAHYALAALEQHR-TLRAIITQNFDGLHQRAGSREVYELHGHLRTATCLEC 136 Query: 122 GQVLDWTGDVTPEDK--CHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMADIFIAIG 177 + + + + C PL+P VV F EM A+ AD+ I G Sbjct: 137 ERQIPTQALLPRIRRGEPPRCSCGHPLKPDVVLFDEMLPRGLYWLARRAVEHADVIIVAG 196 Query: 178 TSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEK 231 TS V+P HGA + +N P+ + G + +PE V + Sbjct: 197 TSLEVFPVNDLPALGLRHGAKLIIINNGPTYLDGRAEAVIRGDVAIALPELVRQ 250 >UniRef50_C1SNI0 NAD-dependent protein deacetylase, SIR2 family n=1 Tax=Denitrovibrio acetiphilus DSM 12809 RepID=C1SNI0_9BACT Length = 256 Score = 223 bits (569), Expect = 3e-57, Method: Composition-based stats. Identities = 59/233 (25%), Positives = 99/233 (42%), Gaps = 8/233 (3%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 + P + TGAG S ESGI +R+ GLW + + +GF +P+ ++ Sbjct: 18 DNPYNVFFTGAGASTESGIPDYRSEGSGLWNRIDSSKLISLKGFLENPKGFYEVFSGGL- 76 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 +PN AH+ +A L++ ++TQNID LH +AG+ N+ +HG + C Sbjct: 77 FAPFAHAEPNVAHMFIAMLEEQKAS-KAVITQNIDGLHRKAGSFNICELHGSMETSSCII 135 Query: 121 SGQVL---DWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMADIFIA 175 G+ + + C ++P +V+FGE ++E + + + I Sbjct: 136 CGKSFSTAEVFDKFMLDGATPECTCGNIVKPDIVFFGESLPKDVLEESFELAAGCTLMIV 195 Query: 176 IGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEF 228 G+S V PA AK HGA V +N + + +V E Sbjct: 196 AGSSLEVMPANLLPKYAKDHGALLVIINKTETPLDYTADIVINKGIGEVFTEL 248 >UniRef50_D1A1X3 Silent information regulator protein Sir2 n=13 Tax=Actinomycetales RepID=D1A1X3_THECD Length = 259 Score = 223 bits (569), Expect = 4e-57, Method: Composition-based stats. Identities = 79/243 (32%), Positives = 118/243 (48%), Gaps = 11/243 (4%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEE-HRVEDVATPEGFDRDPELVQAFYNARRR 60 E + VLTGAGIS +SGI FR G+W + +++ + + DP++ + + ARR Sbjct: 11 EARSITVLTGAGISTDSGIPDFRGPQGVWTKDPSAAALSSLDAYLADPQVRRRVWQARRD 70 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGN--TNVIHMHGELLKVRC 118 +PNAAHLAL KL+ A G +VTQNID LH+ AG+ VI +HG + +V C Sbjct: 71 HPAW-HAEPNAAHLALVKLERA-GRLRAIVTQNIDGLHQAAGSSPKTVIEIHGTMREVEC 128 Query: 119 SQSGQVLDWTGDVTPED----KCHCCQFPAPLRPHVVWFGE--MPLGMDEIYMALSMADI 172 + G + + C + + + FG+ P + A D+ Sbjct: 129 LECGLRTPTQQVLKRLEEGEADPPCLECGGIQKAATISFGQALRPQVLQAAVRAARSCDL 188 Query: 173 FIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 F+A+GTS V+PAAG EA HGA V +N +P+ P + +P VE Sbjct: 189 FMAVGTSLTVHPAAGLCLEAVEHGARLVIVNAQPTPYDGIADAVLREPIGEALPGLVELA 248 Query: 233 LKG 235 L+ Sbjct: 249 LRD 251 >UniRef50_UPI000186F273 NAD-dependent deacetylase HST1, putative n=1 Tax=Pediculus humanus corporis RepID=UPI000186F273 Length = 590 Score = 222 bits (567), Expect = 6e-57, Method: Composition-based stats. Identities = 62/270 (22%), Positives = 101/270 (37%), Gaps = 41/270 (15%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEH--------RVEDVATPEGFDRDPELVQAF 54 ++VLTGAG+S GI FR+ +G++ + + + F++DP F Sbjct: 222 SQNIMVLTGAGVSVSCGIPDFRSRNGIYSRLAVDFPDLPDPQAMFDIQYFNKDPRPFFKF 281 Query: 55 YNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELL 114 R + + +P+ H + L+ G TQNID L + AG VI HG Sbjct: 282 ----ARDIYPGQFKPSPCHRFIRALEQK-GKLLRNYTQNIDTLEQVAGIEKVIQCHGSFA 336 Query: 115 KVRCSQSGQVL---DWTGDVTPEDKCHC--CQ-------------------FPAPLRPHV 150 C++ + + D DV + C C+ ++P + Sbjct: 337 TASCTRCKRKVQADDIREDVFAQKIPICVTCEQDNLPGLNTQDKLDYRDLVCRGIMKPDI 396 Query: 151 VWFGE-MPLGMDEIYM-ALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQ 208 +FGE +P E D+ I IG+S V P A + +NLEP Sbjct: 397 TFFGEGLPEDFHEAMAGDKDKCDLLIVIGSSLKVRPVALIPSSIPAS-VPQILINLEPLP 455 Query: 209 VGNEFAEKYYGPASQVVPEFVEKLLKGLKA 238 N F + G + +V L + + Sbjct: 456 HLN-FDVELLGESDVIVDHICRLLGEEWEE 484 >UniRef50_UPI000051AA14 PREDICTED: similar to NAD-dependent deacetylase sirtuin-1 (hSIRT1) (hSIR2) (SIR2-like protein 1) n=1 Tax=Apis mellifera RepID=UPI000051AA14 Length = 868 Score = 222 bits (567), Expect = 6e-57, Method: Composition-based stats. Identities = 58/242 (23%), Positives = 95/242 (39%), Gaps = 22/242 (9%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEH--------RVEDVATPEGFDRDPELVQA 53 R++VLTGAG+S GI FR+ DG++ + + F +DP Sbjct: 202 NSNRIIVLTGAGVSVSCGIPDFRSRDGIYSRLAQDFPDLPDPQAMFDINYFSQDPRPFYK 261 Query: 54 FYNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGEL 113 F R++ + +P+ H + L D +QNID L + AG NVI HG Sbjct: 262 F----AREIYPGQFKPSPCHRFIKML-DKQKKLLRNYSQNIDTLEQVAGIENVIECHGSF 316 Query: 114 LKVRCSQSGQVL---DWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALS 168 C++ + D D+ + C + ++P +V+FGE D + Sbjct: 317 ATASCTRCKYQVKADDIREDIFSQRIPLCPKC--IMKPDIVFFGEGLPDAFHDAMAKDKD 374 Query: 169 MADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEF 228 D+ I IG+S V P A H + +N E +F + G ++ + Sbjct: 375 ECDLLIVIGSSLKVRPVALIPSSIPSH-VPQILINRESLPH-LKFDVELLGDGDIIINQL 432 Query: 229 VE 230 Sbjct: 433 CH 434 >UniRef50_Q8R984 NAD-dependent deacetylase 2 n=9 Tax=Thermoanaerobacter RepID=NPD2_THETN Length = 250 Score = 222 bits (566), Expect = 7e-57, Method: Composition-based stats. Identities = 67/238 (28%), Positives = 102/238 (42%), Gaps = 15/238 (6%) Query: 3 KPRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 + +VLTGAGIS ESGI FR+ GLWE +V + + PE FY + Sbjct: 20 SQKTMVLTGAGISTESGIPDFRSPGTGLWENMDPTEVLSTKVLFNSPEE---FYRVGFKI 76 Query: 62 LQ-QPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 L +PN AH L++++ G ++TQNIDNLH++AG+ V +HG + C + Sbjct: 77 LSSMRNAEPNEAHYILSEME-KEGIIAGVITQNIDNLHQKAGSKKVYEVHGNTREGSCLR 135 Query: 121 SGQVLDW----TGDVTPEDKCHCCQFPAPLRPHVVWFGE-MPLGMDEIYMALSMADIFIA 175 G+ + + E C + LRP VV FG+ MP D + +D+ I Sbjct: 136 CGEKVSFELLEEKVAKEEIPPRCDRCGGMLRPDVVLFGDPMPHAFDLALKEVQESDLLIV 195 Query: 176 IGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLL 233 IG+S V P + +N + + AS + + Sbjct: 196 IGSSLVVAPVNFLPGMV----DGLIIINATETPYDYKADVVIREKASYALRNIWNLIK 249 >UniRef50_Q5WKC8 NAD-dependent deacetylase n=7 Tax=Bacillaceae RepID=NPD_BACSK Length = 237 Score = 222 bits (565), Expect = 1e-56, Method: Composition-based stats. Identities = 72/221 (32%), Positives = 108/221 (48%), Gaps = 8/221 (3%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 + R++V TGAG+S ESG+ FR++ GL + + E +A+ + + + E FY R Q Sbjct: 8 QAQRIVVFTGAGMSTESGVPDFRSSRGLCKGNNPEALASLQAMNDNREAFVDFYRRRMEQ 67 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 LQ +QP+ + LA + L ++TQN D LHERAGN V+ +HG + K+ C Q Sbjct: 68 LQ--HVQPHKGYDVLATWEQQL-SVTAIITQNTDGLHERAGNQRVLPLHGSIQKLYCIQC 124 Query: 122 GQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMADIFIAIGTS 179 GQ D + + C +RP VV FGE + AD+FI +G+S Sbjct: 125 GQHYDVDRYMNNQPS---CSCGGFIRPSVVLFGEPLDSNILALAEQHSIEADVFIVLGSS 181 Query: 180 GHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGP 220 V PA F AK HGA + +N + + + Sbjct: 182 LVVSPANLFPRIAKEHGAKLIIVNHDSTPLDTIADYVVNDK 222 >UniRef50_B3T8H4 Putative Sir2 family protein n=1 Tax=uncultured marine microorganism HF4000_APKG5H11 RepID=B3T8H4_9ZZZZ Length = 273 Score = 222 bits (565), Expect = 1e-56, Method: Composition-based stats. Identities = 67/234 (28%), Positives = 104/234 (44%), Gaps = 12/234 (5%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQ--AFYNAR 58 + V+VL GAG+S ESGI FR GLW ++ + F +DP+ F N Sbjct: 20 LSSSYVVVLAGAGLSVESGIPPFRGPGGLWTKYGEPTNLSYHEFTKDPKEWWEARFRNED 79 Query: 59 RR-------QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHG 111 R ++ + +PN H AL +++ A+G ++TQN+DNLH AG+ +++ +HG Sbjct: 80 RPGDPTYELKVAVDQARPNPGHHALVEME-AMGLLKCVITQNVDNLHREAGSNSLLEIHG 138 Query: 112 ELLKVRCSQSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSM 169 +RC G G C Q ++ V FGE + Sbjct: 139 NGTWLRCVGCGVRQPRDGYHFDSLPPICTQCGGVIKMDTVMFGEPIPEDVLLASREQAEA 198 Query: 170 ADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQ 223 D + +GTSG V PAA AK GA +E+N + + + GP+ + Sbjct: 199 CDCMLLVGTSGTVNPAARLPLVAKELGATLIEINPDETTLTPSCDITLNGPSGE 252 >UniRef50_A1DG07 SIR2 family histone deacetylase, putative n=8 Tax=Eurotiomycetidae RepID=A1DG07_NEOFI Length = 425 Score = 222 bits (565), Expect = 1e-56, Method: Composition-based stats. Identities = 65/244 (26%), Positives = 91/244 (37%), Gaps = 21/244 (8%) Query: 4 PRVLVLTGAGISAESGIRTFRAAD-GLWEEH------RVEDVATPEGFDRDPELVQAFYN 56 R++V+ GAGIS +GI FR+ D GL+ EDV F +P + FY Sbjct: 36 RRIVVMVGAGISTSAGIPDFRSPDTGLYSNLAFLDLPEPEDVFDISYFRENP---RPFYA 92 Query: 57 ARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGN--TNVIHMHGELL 114 R L +P AH + L D G TQNID L AG ++ HG Sbjct: 93 LARE-LAPGRYRPTIAHSFVKLLHDK-GLLLKHFTQNIDCLERLAGVPGEKIVEAHGSFA 150 Query: 115 KVRCSQSGQVLD---WTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMAL-SMA 170 C + + HC ++P +V+FGE +L A Sbjct: 151 SQHCIDCKAAYPEPQMKEAIAKGEVPHCPHCNGFVKPDIVFFGEALPEEFHANRSLPEQA 210 Query: 171 DIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQ--VGNEFAEKYYGPASQVVPEF 228 D+ I +GTS V+P A + G V +N+E G V +F Sbjct: 211 DLCIVMGTSLTVHPFASLPSFCRE-GVPRVLINMERVGGMGSRPDDVLLLGDCDAGVRKF 269 Query: 229 VEKL 232 L Sbjct: 270 ARAL 273 >UniRef50_A9A0B2 NAD-dependent deacetylase n=1 Tax=Desulfococcus oleovorans Hxd3 RepID=NPD_DESOH Length = 273 Score = 221 bits (564), Expect = 1e-56, Method: Composition-based stats. Identities = 78/255 (30%), Positives = 113/255 (44%), Gaps = 26/255 (10%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGF----DRDPELVQAFYNAR 58 R V +GAG+SAESGI TFR G+W+ +V +G +++PE + A + Sbjct: 17 ASRAAVFSGAGVSAESGIPTFRDPGGVWDRLNPAEVGDTQGLLASLEKNPEKLVAMFMEL 76 Query: 59 RRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRC 118 PN H AL L+ +G ++TQNIDNLH+ AGNT VI MHG + RC Sbjct: 77 LAVF--DAAIPNPGHRALFDLE-RMGILQAVITQNIDNLHQEAGNTQVIEMHGNGFRFRC 133 Query: 119 SQSGQV-------------------LDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLG 159 + D++ C + +RP VV FGE + Sbjct: 134 LKCRSRRSHERHALIGRVKERLSTLPDFSPASIFAAMPDCDLCGSGMRPDVVMFGETVME 193 Query: 160 MDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYG 219 ++ + A D+ +A+GTSG V PAA EAK GA + +N + Sbjct: 194 VENAFAAARSCDVMLALGTSGVVTPAAQIPAEAKASGAKVIVINPNENGFARVCDIYISM 253 Query: 220 PASQVVPEFVEKLLK 234 Q +P VE++ K Sbjct: 254 KTGQALPRIVEQVKK 268 >UniRef50_Q89LY4 NAD-dependent deacetylase 1 n=18 Tax=Proteobacteria RepID=NPD1_BRAJA Length = 254 Score = 220 bits (562), Expect = 2e-56, Method: Composition-based stats. Identities = 72/232 (31%), Positives = 103/232 (44%), Gaps = 12/232 (5%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARR-R 60 E ++ TGAGIS E GI FR+ G+W +R +GF E + R Sbjct: 21 EAKTIVPFTGAGISTECGIPDFRSPGGIWTRNRPIPF---DGFVASQEARDESWRRRFAM 77 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELLKVRC 118 + +P H ALA L A G ++TQNIDNLH+ +G + +VI +HG RC Sbjct: 78 EETFAAARPGRGHRALASLYRA-GKVPAVITQNIDNLHQASGFAHEHVIELHGNTTYARC 136 Query: 119 SQSGQVLDWTGDVTPEDK---CHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMADIF 173 GQ D+ +C P++ + FG+M M D+F Sbjct: 137 VGCGQTYQLDWVKRRFDQDGAPNCTVCDEPVKTATISFGQMMPEEEMQRATALSRACDLF 196 Query: 174 IAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVV 225 IAIG+S V+PAAGF AK GA V +N EP++ + + + Sbjct: 197 IAIGSSLVVWPAAGFPMMAKRAGARLVIINREPTEQDDIADLVIRHDIGETL 248 >UniRef50_D0NEH2 NAD-dependent histone deacetylase sir2-like protein n=1 Tax=Phytophthora infestans T30-4 RepID=D0NEH2_PHYIN Length = 570 Score = 220 bits (562), Expect = 3e-56, Method: Composition-based stats. Identities = 58/250 (23%), Positives = 101/250 (40%), Gaps = 18/250 (7%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEH------RVEDVATPEGFDRDPELVQAFYN 56 +++VL GAGIS GI FR+ +G++ + + E F +P+ AF Sbjct: 206 SKKIVVLAGAGISVSCGIPDFRSENGIYSRLGEYNLPNPQCMFDIEFFRSNPKPFFAFAK 265 Query: 57 ARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELL 114 + P+ +H L L++ G + +QNID L AG + + + HG Sbjct: 266 ELFPKSSGFTFVPSPSHYFLKLLEEK-GKLLRIYSQNIDMLEHAAGISHEHAVLCHGSFA 324 Query: 115 KVRCSQSGQVLD---WTGDVTPEDKCHCCQFPAP---LRPHVVWFGEMPLG--MDEIYMA 166 C + DV + C +P ++P +V+FGE D + Sbjct: 325 TATCVACKRTYPNDAIREDVLNQRVPMCQSCNSPDGIIKPDIVFFGESLPRRFHDSVKSD 384 Query: 167 LSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVP 226 AD+ + +G+S V P V K + + +N EP ++F + G + ++V Sbjct: 385 EGEADLVLVMGSSLKVNPVRSIVGRFK-NDTPMILINREPVGRPHKFDVELLGYSDEIVQ 443 Query: 227 EFVEKLLKGL 236 E L + Sbjct: 444 ELCRLLGWEI 453 >UniRef50_C1AAZ7 NAD-dependent deacetylase n=4 Tax=Bacteria RepID=C1AAZ7_GEMAT Length = 327 Score = 219 bits (559), Expect = 5e-56, Method: Composition-based stats. Identities = 85/244 (34%), Positives = 116/244 (47%), Gaps = 7/244 (2%) Query: 3 KPRVLVLTGAGISAESGIRTFRA-ADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 V VLTGAGISAESGI TFR GLW + +++ATP+ F P V +Y RR Sbjct: 86 AEHVCVLTGAGISAESGIPTFREAQTGLWAKFSPQELATPQAFASHPSRVWQWYAMRRAM 145 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 ++ QPN H AL L + +VTQN+D+LHER+G I +HG L+ +RCSQ Sbjct: 146 VRA--AQPNPGHAALLSLALRVAH-CTIVTQNVDDLHERSGVREPIRLHGSLMHIRCSQG 202 Query: 122 GQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPL--GMDEIYMALSMADIFIAIGTS 179 + + C Q +RP VVWFGE A D+F+++GTS Sbjct: 203 CAGSVPAPEEATAEVPKCPQCGGLMRPDVVWFGEGLPMGPFGAAREAAVACDVFLSVGTS 262 Query: 180 GHVYPAAGFVHEAKLHGAHTVELNLE-PSQVGNEFAEKYYGPASQVVPEFVEKLLKGLKA 238 V PAA + HGA + +N Q GPA ++P + + G + Sbjct: 263 NIVEPAASLPWISATHGATVIVVNPTMEGQRKGPSILPIEGPAGVMLPRLIAEAFAGRRP 322 Query: 239 GSIA 242 A Sbjct: 323 RRQA 326 >UniRef50_Q0AY57 Regulatory protein, sir2 family n=1 Tax=Syntrophomonas wolfei subsp. wolfei str. Goettingen RepID=Q0AY57_SYNWW Length = 253 Score = 219 bits (559), Expect = 5e-56, Method: Composition-based stats. Identities = 76/243 (31%), Positives = 115/243 (47%), Gaps = 11/243 (4%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEH---RVEDVATPEGFDRDPELVQAFYNAR 58 +V+TGAGIS E+GI FR +G++ + RV + + F +P FY Sbjct: 14 RSHNTVVVTGAGISTEAGIPDFRGPEGIYRKLGENRVMKIINIDFFRNNPLEFYKFY--- 70 Query: 59 RRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRC 118 R+ P ++P AH LA+++ G +VTQNIDNLH++AG+ VI +HG + C Sbjct: 71 RQYFIFPPVEPGKAHQVLAEME-KAGIIKAIVTQNIDNLHQKAGSQKVIPIHGNGARFLC 129 Query: 119 S--QSGQVLDWTGDVTPED-KCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIA 175 V D T + C Q L+P VV FGE + + A + + Sbjct: 130 QERNCRSVHDSNYVNTYPEVIPRCSQCGGILKPDVVLFGEHIKNYPDAMDRILGARVLVV 189 Query: 176 IGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYY-GPASQVVPEFVEKLLK 234 IG+S VYP AGFV E + + +N P+ + + K G +++ E EK+ K Sbjct: 190 IGSSLTVYPLAGFVKEFSTFTQYLIIINKGPTPLDHAAVVKLQEGNTGELLEEIFEKIKK 249 Query: 235 GLK 237 K Sbjct: 250 RRK 252 >UniRef50_A9AWG1 Silent information regulator protein Sir2 n=3 Tax=Bacteria RepID=A9AWG1_HERA2 Length = 244 Score = 219 bits (559), Expect = 6e-56, Method: Composition-based stats. Identities = 91/233 (39%), Positives = 126/233 (54%), Gaps = 9/233 (3%) Query: 4 PRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQ 63 ++VLTGAGIS SG+R FR +G+W E +E AT ++ P+LV + R QLQ Sbjct: 11 RNIVVLTGAGISVASGVRPFRGPNGVWNEWDIERCATRTALEQSPQLVWQAFGPLRSQLQ 70 Query: 64 QPEIQPNAAHLALAKLQDALGD--RFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ- 120 QPNAAH ALA+ + +LG RF L+TQNID LH+ AG+ N++ HG L + RCS Sbjct: 71 --TTQPNAAHRALARFEQSLGKHQRFTLITQNIDGLHQLAGSRNLVEFHGSLRQSRCSDE 128 Query: 121 -SGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDE--IYMALSMADIFIAIG 177 Q + C PLRP +V F E E +L D F+A+G Sbjct: 129 QCDQPSFVDQRAHTQTLPLCPTCGKPLRPDIVLFEEAIPVWAETQAKRSLRECDFFLAVG 188 Query: 178 TSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYY-GPASQVVPEFV 229 TSG V+PAA F A++ GA T+ +NLEP + E+ G A +++P + Sbjct: 189 TSGTVFPAAAFARTAQMLGARTMLVNLEPHAADDSAFEEQQIGRAEELLPTLL 241 >UniRef50_Q9I4L0 NAD-dependent deacetylase 1 n=28 Tax=Bacteria RepID=NPD1_PSEAE Length = 250 Score = 219 bits (558), Expect = 6e-56, Method: Composition-based stats. Identities = 88/243 (36%), Positives = 123/243 (50%), Gaps = 13/243 (5%) Query: 3 KPRVLVLTGAGISAESGIRTFRAA-DGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 R+++ TGAG+SAESGI TFR A GLW + +ATP F DP LV +Y RR + Sbjct: 11 ARRLVIFTGAGVSAESGIPTFRDALGGLWARYDPAALATPAAFADDPALVWGWYEWRRLK 70 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 + +QPN AH A+A L + LVTQN+D+LHERAG+ +V+H+HG L RC+ Sbjct: 71 VL--GVQPNPAHRAIAALSGRIA-NTRLVTQNVDDLHERAGSRDVLHLHGSLHAPRCATC 127 Query: 122 GQVLDW-------TGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALS--MADI 172 + + C +RP VVWFGE + D+ Sbjct: 128 AAAYRDALPDSVEPEEGRRIEPPRCPACGGQVRPGVVWFGEALPEAALREAFAAACECDL 187 Query: 173 FIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 +++GTSG V PAA A HGA V +N +P + + GPA +V+PE + + Sbjct: 188 LLSVGTSGVVQPAARIPGLALEHGASVVHVNPQPVRTRHPREHCLVGPAGEVLPELLRRA 247 Query: 233 LKG 235 G Sbjct: 248 FPG 250 >UniRef50_B8FEP4 Silent information regulator protein Sir2 n=1 Tax=Desulfatibacillum alkenivorans AK-01 RepID=B8FEP4_DESAA Length = 252 Score = 219 bits (558), Expect = 8e-56, Method: Composition-based stats. Identities = 68/237 (28%), Positives = 108/237 (45%), Gaps = 12/237 (5%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 E R + TGAGIS ESGI FR+ G+W+++R + F + +++ + Sbjct: 14 EGGRNIAFTGAGISTESGIPDFRSQGGIWDQYRPV---YFDEFMSSRDARVRYWDQKIAM 70 Query: 62 L-QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGN--TNVIHMHGELLKVRC 118 + +PNA H ALAKL D +G ++TQNID LH+ +G VI +HG +VRC Sbjct: 71 WDGLEKARPNAGHQALAKLYD-MGLLEAIITQNIDGLHQESGIPGDKVIELHGNTRRVRC 129 Query: 119 SQSGQ---VLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPL--GMDEIYMALSMADIF 173 G+ V + + D C L+P + FG+ ++ S D F Sbjct: 130 MTCGETSTVAEAKQRILDGDPAPECHCGGYLKPDTISFGQAMPQKEVEAAARLSSSCDFF 189 Query: 174 IAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVE 230 + +G++ V+PAA A+ GA+ +NL + N A V+ + Sbjct: 190 LVVGSTLVVHPAAMMPEYARRAGAYLAIVNLSDTPYDNACQALVREKAGPVLQAIAD 246 >UniRef50_C3IUP0 SIR2 n=2 Tax=Bacillus thuringiensis RepID=C3IUP0_BACTU Length = 241 Score = 218 bits (556), Expect = 1e-55, Method: Composition-based stats. Identities = 68/237 (28%), Positives = 111/237 (46%), Gaps = 11/237 (4%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 + ++VLTGAGIS +SG+ +R+ GLW+ + E+++ + PE V+ F + Sbjct: 11 KSNHIVVLTGAGISTDSGLPDYRSNGGLWDGKKPEEISHFSAVGK-PEFVKFFADRMNDI 69 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 +PN AH LAK ++ G ++TQNID+ H+ AG+ NVI MHG L + C Sbjct: 70 ---SNCKPNKAHEILAKWEEQ-GKVKSVITQNIDSYHKDAGSKNVIEMHGHLRNLVCDTC 125 Query: 122 GQVLDWTGDVTPEDKCHC---CQFPAPLRPHVVWFGEMPL--GMDEIYMALSMADIFIAI 176 + D T EDK +C + +RP VV FGE + + D+ I + Sbjct: 126 SKEYD-NSMYTKEDKDNCGLEWECTGVVRPEVVLFGETLPPLAWHQANEQMKKTDLVIVL 184 Query: 177 GTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLL 233 GTS V+P V A + + + + + + Y ++ + E +L Sbjct: 185 GTSLQVFPFNSLVESVYPGKAPVMIITKSDTPYDHMASVRIYDNITETLVEIDNRLK 241 >UniRef50_Q6BVM7 DEHA2C01386p n=4 Tax=Saccharomycetaceae RepID=Q6BVM7_DEBHA Length = 301 Score = 218 bits (556), Expect = 1e-55, Method: Composition-based stats. Identities = 82/291 (28%), Positives = 123/291 (42%), Gaps = 57/291 (19%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 M+ R++ L GAG+S SG+ TFR + GLW+ + D+ATP+ F DP LV FY+ RR Sbjct: 13 MKSKRIVALVGAGLSVSSGLPTFRGSQGLWKNFNMIDLATPDAFYIDPGLVWQFYSWRR- 71 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGN--TNVIHMHGELLKVRC 118 + + +PN HLALAKL F+ +TQN+D L RAG+ + +HG L +RC Sbjct: 72 -INASKAKPNKGHLALAKLSKLSNIEFMTITQNVDGLSIRAGHPKEKLHEIHGSLFDLRC 130 Query: 119 SQ--SGQ-----------------------------------------VLDWTGDVTPED 135 + + E+ Sbjct: 131 TSFMCNYVDHDNFKNPLTKALADTEFEYDKSGRKRKIIDETEVNKLSPQFAPVKQIPEEE 190 Query: 136 KCHCCQF--PAPLRPHVVWFGEMPL----GMDEIYMALSMADIFIAIGTSGHVYPAAGFV 189 C + LRP VVWFGE + ++ D+ + IGTSG VYPA +V Sbjct: 191 LPQCPVCEDGSLLRPGVVWFGESLPLQTIDKIDNFIESDKIDLILVIGTSGTVYPANSYV 250 Query: 190 HEAKLHGAHTVELNLEPS----QVGNEFAEKYYGPASQVVPEFVEKLLKGL 236 KL G N + + + G A++++P ++ L+ L Sbjct: 251 DRIKLKGGKVAIFNTDIESEILNGEEKDTWGFQGDAAELLPIALKPLIGDL 301 >UniRef50_A5USR3 Silent information regulator protein Sir2 n=3 Tax=Chloroflexi (class) RepID=A5USR3_ROSS1 Length = 259 Score = 218 bits (555), Expect = 2e-55, Method: Composition-based stats. Identities = 80/240 (33%), Positives = 118/240 (49%), Gaps = 7/240 (2%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAA-DGLWEEHRVEDVATPEGFDRDPELVQAFYNARR 59 + RV+ LTG G++AESGI +FR A G W ++ V ++ATP+ F R+P LV +Y RR Sbjct: 14 INARRVVALTGGGVAAESGIPSFREAHTGHWAQYDVSELATPQAFVRNPRLVWEWYAYRR 73 Query: 60 RQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCS 119 + QP H AL L+ F L+TQ+ID LH RAG+ ++I ++G L + RC Sbjct: 74 --MLAERAQPGVTHYALVDLEQHYP-AFTLITQSIDGLHWRAGSRDLIELNGSLRRCRCF 130 Query: 120 QSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMD--EIYMALSMADIFIAIG 177 +SG + D C Q + LRP VV FGE + A+ D+F+ +G Sbjct: 131 ESGHIAFAWDDDGEIP-PRCVQCGSLLRPDVVMFGEGLPHHELRRARQAVEQCDVFLCVG 189 Query: 178 TSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKGLK 237 T G + P A F A+ HGA + + E S + E V ++ + Sbjct: 190 TVGAIEPVASFPFVARRHGAFVMTIAPEDSIYTLMADYVIAAQPGVIASELVRLIVGDVG 249 >UniRef50_C1VAT1 NAD-dependent protein deacetylase, SIR2 family n=1 Tax=Halogeometricum borinquense DSM 11551 RepID=C1VAT1_9EURY Length = 270 Score = 217 bits (554), Expect = 2e-55, Method: Composition-based stats. Identities = 70/246 (28%), Positives = 103/246 (41%), Gaps = 10/246 (4%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 V VLTGAG+S SG+ TFR +G+W + F+RDP ++ Sbjct: 15 ADGVTVLTGAGVSNASGVPTFRGEEGIWNNEFDPADFRMDRFERDPAGFWTDRLELHERM 74 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG 122 PN AH ALA+L+D LG ++VTQN D LH AG +I +HG + C + G Sbjct: 75 FGDVTGPNDAHRALARLED-LGVVDVVVTQNTDGLHAEAGTNRLIELHGNNARSVCVECG 133 Query: 123 QVLD----WTGDVTPEDKCHCC--QFPAPLRPHVVWFGEMPL--GMDEIYMALSMADIFI 174 + + C L+P VV FGE D +D+FI Sbjct: 134 ESVPTETALDDVRAGNSPPSCPVVGCTGHLKPDVVLFGERLPGGAYDSARRMAWESDVFI 193 Query: 175 AIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLK 234 +G+S V PA+ EA G + ++ + G A++ +P VE + Sbjct: 194 VVGSSLTVVPASTLPEEAAERG-QLAIFDTGETEKDHLAHYLVRGDATETLPALVEAVQA 252 Query: 235 GLKAGS 240 L + Sbjct: 253 RLGREA 258 >UniRef50_Q12Y78 NAD-dependent deacetylase, Sir2-like n=1 Tax=Methanococcoides burtonii DSM 6242 RepID=Q12Y78_METBU Length = 245 Score = 217 bits (554), Expect = 2e-55, Method: Composition-based stats. Identities = 60/230 (26%), Positives = 107/230 (46%), Gaps = 11/230 (4%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 +VLTGAG+S SGI FR G++ + + + + + F++DP FY + Sbjct: 10 NSEYCVVLTGAGVSTFSGIPDFRGRSGVYNKFDADLIFSIDHFNKDPA---YFYAHSKSF 66 Query: 62 LQQPEIQ-PNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 + E + P+ H L+KL++ G ++TQNID LH++AG+ NVI +HG + C Sbjct: 67 IYDLEHRQPSIVHSVLSKLEEK-GIIKAIITQNIDMLHQKAGSKNVIEVHGSPQEHVCLA 125 Query: 121 SGQVLDWTGDVTPEDK---CHCCQFPAPLRPHVVWFGEMP--LGMDEIYMALSMADIFIA 175 G+ + C + ++P +V++GEM +++ S AD+ + Sbjct: 126 CGKKYSYEYIAELLKAEGFPLCNECGGLVKPDIVFYGEMLRQDTIEKAIQESSKADLMLV 185 Query: 176 IGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVV 225 +G++ V PAA +G V +N + + ++ Y V Sbjct: 186 LGSTLVVQPAASLPLYTIENGGELVIVNDMKTPLDGYA-KRLYDDLGDVF 234 >UniRef50_UPI0001925E2D PREDICTED: similar to NAD-dependent deacetylase sirtuin-1 n=1 Tax=Hydra magnipapillata RepID=UPI0001925E2D Length = 424 Score = 217 bits (554), Expect = 2e-55, Method: Composition-based stats. Identities = 65/255 (25%), Positives = 100/255 (39%), Gaps = 25/255 (9%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEH--------RVEDVATPEGFDRDPELVQA 53 E ++VLTGAG+S GI FR+ DG++ + + F +P Sbjct: 96 ESKNIIVLTGAGVSVSCGIPDFRSRDGIYARLHKDYPDLPDPQAMFDIHYFRNNPWPFFK 155 Query: 54 FYNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGEL 113 F +++ + P+ H ++KL D G TQNID L + AG NV+ HG Sbjct: 156 F----AKEIYPGQFTPSLCHRFISKL-DQQGKLLRNYTQNIDTLEQVAGIKNVLQCHGSC 210 Query: 114 LKVRCSQSGQVL---DWTGDVTPEDKCHCCQFPAP-----LRPHVVWFGEMPLG--MDEI 163 C + D+ + +C Q P L+P +V+FGE +I Sbjct: 211 ATATCMNCKYKVSAEFIKEDIFQQKIPYCNQCSDPNSLNILKPDIVFFGESLSDDFYSQI 270 Query: 164 YMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQ 223 AD+ I IG+S V P A K + + +N E EF + YG Sbjct: 271 NKDKDEADLLIVIGSSLKVRPVALIPSLIKQN-VPQLLINREQLHHI-EFDVEMYGNCDD 328 Query: 224 VVPEFVEKLLKGLKA 238 V+ +L + Sbjct: 329 VICYLCSELGREWTD 343 >UniRef50_Q8CJM9 NAD-dependent deacetylase 2 n=8 Tax=Actinomycetales RepID=NPD2_STRCO Length = 241 Score = 217 bits (553), Expect = 2e-55, Method: Composition-based stats. Identities = 73/236 (30%), Positives = 105/236 (44%), Gaps = 11/236 (4%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEE-HRVEDVATPEGFDRDPELVQAFYNARRRQLQQ 64 V +L+GAG+S +SGI +R +GLW E + T E + DPE+ + + RR Sbjct: 7 VAILSGAGVSTDSGIPDYRGPNGLWRRDPEAEKLVTYEYYMGDPEIRRRSWLMRRDS-AA 65 Query: 65 PEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNT--NVIHMHGELLKVRCSQSG 122 +PNAAH A+A L+ G ++TQN+D LH+ AG + V+ +HG C+ G Sbjct: 66 LHAEPNAAHRAVADLERR-GVPVRVLTQNVDGLHQLAGVSARKVLELHGTARDCVCTGCG 124 Query: 123 QVLDWTGDVTPE----DKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMADIFIAI 176 + D C L+ V FGE + E +F+A+ Sbjct: 125 ARGPMADVLARIEAGEDDPPCLDCGGVLKTATVMFGERLDPVVLGEAAAISKACQVFVAV 184 Query: 177 GTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 GTS V PAAG A HGA V +N EP+ E P +P + L Sbjct: 185 GTSLQVEPAAGLARVAVEHGARLVVVNAEPTPYDELADEVIREPIGSALPALLRGL 240 >UniRef50_A2QFF9 Complex: Sir2p is one of four Silent Information Regulator genes in yeast. Sir2p n=19 Tax=Dikarya RepID=A2QFF9_ASPNC Length = 378 Score = 216 bits (551), Expect = 5e-55, Method: Composition-based stats. Identities = 62/243 (25%), Positives = 89/243 (36%), Gaps = 21/243 (8%) Query: 4 PRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEG------FDRDPELVQAFYN 56 RV+V+ GAGIS +GI FR+ D G++ D+ PE F ++P + FY Sbjct: 36 KRVVVMVGAGISTSAGIPDFRSPDTGIYSNLAHLDLPDPEAVFDISFFRQNP---RPFYA 92 Query: 57 ARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGN--TNVIHMHGELL 114 R L + +P AH + L D G +QNID L AG ++ HG Sbjct: 93 LARE-LAPGQFRPTIAHSFIKLLYDK-GMLLKHFSQNIDCLERLAGVPGDKIVEAHGSFA 150 Query: 115 KVRCSQSGQVLD---WTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPL-GMDEIYMALSMA 170 C +T +C Q ++P +V+FGE + A Sbjct: 151 TQHCIDCKAEYPEDLMKKAITKGKVPYCTQCKGLVKPDIVFFGESLPADFFDNRDLPEQA 210 Query: 171 DIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQ--VGNEFAEKYYGPASQVVPEF 228 D+ I +GTS V P A G V +N+E G V Sbjct: 211 DLCIVMGTSLQVQPFASLPAFVSD-GVPRVLINMERVGGLGSRPDDVLVLGDCDTGVRRL 269 Query: 229 VEK 231 Sbjct: 270 ARA 272 >UniRef50_B0CZ35 Class I sirtuins SIR2 family protein n=2 Tax=Agaricales RepID=B0CZ35_LACBS Length = 395 Score = 216 bits (551), Expect = 5e-55, Method: Composition-based stats. Identities = 59/252 (23%), Positives = 93/252 (36%), Gaps = 28/252 (11%) Query: 3 KPRVLVLTGAGISAESGIRTFRAAD--------GLWEEHRVEDVATPEG------FDRDP 48 ++++ GAG+S +GI FR+ L+ ++ PE F R+P Sbjct: 36 CKNIVLMLGAGVSTSAGIPDFRSPGTGQSRSSHYLFSNLARLNLPHPEAVFEISFFRRNP 95 Query: 49 ELVQAFYNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNT--NV 106 FY L + +P AH + L + + TQNID L RAG + Sbjct: 96 ---VPFYTLAHE-LYPGKFRPTIAHSFIRLLAEHS-LLYQCFTQNIDTLERRAGVPDGKI 150 Query: 107 IHMHGELLKVRCSQSGQVLD---WTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPL-GMDE 162 I HG RC + D + + C + ++P +V+FGE Sbjct: 151 IEAHGSFATQRCIDCEEPFDDEVMKQHIKDKKIATCEECGGLVKPDIVFFGESLPINFIR 210 Query: 163 IYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQ--VGNEFAEKYYGP 220 L AD+ I +GTS V P A V + V +NL+ G Sbjct: 211 AIPLLQEADLLIVMGTSLTVQPFASLVERV-DNSCPRVLINLDRVGSIGSRSDDVVLLGK 269 Query: 221 ASQVVPEFVEKL 232 +V + ++L Sbjct: 270 CDDIVRDLCKEL 281 >UniRef50_A6TNA0 Silent information regulator protein Sir2 n=2 Tax=Clostridiales RepID=A6TNA0_ALKMQ Length = 249 Score = 216 bits (550), Expect = 7e-55, Method: Composition-based stats. Identities = 71/235 (30%), Positives = 96/235 (40%), Gaps = 12/235 (5%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 + ++LTGAG+ ES I FR+ G W VA + F + L FY+ R R Sbjct: 23 KSKDTVILTGAGMDTESNIPDFRSEKGWWRSIDPRTVANIDTFYENYSLFHEFYDMRLRL 82 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 L IQP+ H L+ L+ G + TQN+ LH AG+ NV +HG + K+RC+ Sbjct: 83 L--VGIQPHKGHYILSDLEKK-GMIRSIATQNVAGLHVMAGSQNVYELHGNIRKIRCNNC 139 Query: 122 GQVLDWTGDVTPEDKCHCCQFPAP-LRPHVVWFGEMPL--GMDEIYMALSMADIFIAIGT 178 + E C LRP V+ FGE D + D+ I IGT Sbjct: 140 NHEASLERFLAVET---CGSCGDKGLRPSVILFGETLPPKAWDSALRDIQKCDLLIVIGT 196 Query: 179 SGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLL 233 S VYP K V +N E F G A +V+ LL Sbjct: 197 SLEVYPVNHLPMLTK---GKKVFINNEERSTDYAFDLTIIGKAKEVLEALNHYLL 248 >UniRef50_B4VCV9 SIR2 family transcriptional regulator n=3 Tax=Actinomycetales RepID=B4VCV9_9ACTO Length = 241 Score = 216 bits (550), Expect = 7e-55, Method: Composition-based stats. Identities = 71/241 (29%), Positives = 105/241 (43%), Gaps = 11/241 (4%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAADGLWEE-HRVEDVATPEGFDRDPELVQAFYNARR 59 M KP V V +GAG+S +SGI +R GLW E + T E + DPE+ + + R Sbjct: 1 MGKPLVAVFSGAGMSTDSGIPDYRGPQGLWRRDPDAEKLVTYEYYMADPEIRRRSWR-MR 59 Query: 60 RQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNT--NVIHMHGELLKVR 117 ++ +PNAAH A+A+L D G ++TQN+D LH+ AG V +HG V Sbjct: 60 AEIGALGARPNAAHRAVAEL-DRGGTPVRVITQNVDGLHQLAGMPARKVFELHGTARSVL 118 Query: 118 CSQSGQVLDWTGDVTP----EDKCHCCQFPAPLRPHVVWFGEM--PLGMDEIYMALSMAD 171 C+ + E C L+ V FGE P + + Sbjct: 119 CTACHARSGMEEALARVAAGEPDPACLACGGILKSATVMFGERLDPQVLAQAVAVAKGCQ 178 Query: 172 IFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEK 231 +FIA+GT+ V PAA A GA + +N E + E P +P + + Sbjct: 179 VFIAVGTTLQVQPAASLAGMAATAGARLIIVNAEETPYDELADEVIREPIGTALPALLTR 238 Query: 232 L 232 + Sbjct: 239 I 239 >UniRef50_Q21921 NAD-dependent deacetylase SIR2 homolog n=2 Tax=Caenorhabditis RepID=SIRT1_CAEEL Length = 607 Score = 215 bits (549), Expect = 7e-55, Method: Composition-based stats. Identities = 59/240 (24%), Positives = 95/240 (39%), Gaps = 20/240 (8%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEH--------RVEDVATPEGFDRDPELVQAF 54 K +LVLTGAG+S GI FR+ DG++ + F +P F Sbjct: 145 KKHILVLTGAGVSVSCGIPDFRSKDGIYARLRSEFPDLPDPTAMFDIRYFRENPAP---F 201 Query: 55 YNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELL 114 YN R + P+ +H + +L+ + G TQNID L + G V+ HG Sbjct: 202 YNFAREIF-PGQFVPSVSHRFIKELETS-GRLLRNYTQNIDTLEHQTGIKRVVECHGSFS 259 Query: 115 KVRCSQSGQVLD---WTGDVTPEDKCHCCQFPAPLRPHVVWFGEMP--LGMDEIYMALSM 169 K C++ GQ D +V HC + ++P++V+FGE + Sbjct: 260 KCTCTRCGQKYDGNEIREEVLAMRVAHCKRCEGVIKPNIVFFGEDLGREFHQHVTEDKHK 319 Query: 170 ADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFV 229 D+ + IG+S V P A + + +N E N + G ++ + Sbjct: 320 VDLIVVIGSSLKVRPVA-LIPHCVDKNVPQILINRESLPHYN-ADIELLGNCDDIIRDIC 377 >UniRef50_D2RWQ5 Silent information regulator protein Sir2 n=2 Tax=Halobacteriaceae RepID=D2RWQ5_9EURY Length = 271 Score = 215 bits (548), Expect = 1e-54, Method: Composition-based stats. Identities = 71/258 (27%), Positives = 106/258 (41%), Gaps = 30/258 (11%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 V+ TGAGISA SG+ TFR G+WE+ T F DP +R++ Sbjct: 14 ADTVVAFTGAGISAPSGVPTFRGDGGVWEKFDEGQ-FTYGRFRSDPAGFWDDRVDLQREM 72 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGN------------------- 103 QPNAAH ALA + G ++TQN D LH +A + Sbjct: 73 FAEVYQPNAAHEALAAM-GRDGHLEAILTQNTDGLHAQAADAVSGDSSGDSDGADANGDA 131 Query: 104 ----TNVIHMHGELLKVRCSQSGQVLDW---TGDVTPEDKCHCCQFPAPLRPHVVWFGEM 156 T ++ +HG +VRC+ G+ D + C +P VV FG+ Sbjct: 132 ADDNTTLLELHGNARRVRCTDCGRRRDADPVFDRAAEGELPPTCDCGGVFKPDVVLFGQQ 191 Query: 157 PL--GMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFA 214 + +D+F+A+G+S V PAA +A GA +NLE + V + Sbjct: 192 LPGTVIQRARSLARESDVFLAVGSSLVVEPAASLPRQAASTGATLGIVNLESTPVDDAAD 251 Query: 215 EKYYGPASQVVPEFVEKL 232 ++V+P E + Sbjct: 252 VVRREDVTEVLPRLRELV 269 >UniRef50_A3ZMQ7 Sir2 family, possible ADP ribosyltransferase n=1 Tax=Blastopirellula marina DSM 3645 RepID=A3ZMQ7_9PLAN Length = 252 Score = 215 bits (548), Expect = 1e-54, Method: Composition-based stats. Identities = 65/241 (26%), Positives = 101/241 (41%), Gaps = 12/241 (4%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR- 60 E ++ TGAGIS ESGI FR+ G+W ++R + F + E + ++ + Sbjct: 16 ESESTVLFTGAGISTESGIPDFRSPGGVWTKYR---TIYFDEFRQSAEARREYWRQKSEA 72 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 ++ PNA H LA + G L+TQNID LH+ AG+ V+ +HG + C Sbjct: 73 HVEFSAAAPNAGHQILAAWEAH-GVARGLITQNIDGLHQIAGSRQVLELHGTAREATCLD 131 Query: 121 SGQVLDWTGDVTPEDK----CHCCQF-PAPLRPHVVWFGEMPLG--MDEIYMALSMADIF 173 + V + C L+ V FG+M ++ Y S AD+ Sbjct: 132 CAARFEIDPLVVQFRETGEVPPCPNCETGRLKHATVSFGQMLPTDVLETAYDWCSDADLI 191 Query: 174 IAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLL 233 +AIG+S V PAA + G V LN + + + K G + L Sbjct: 192 LAIGSSLVVTPAADLPVAVRRRGGRVVILNRDETGLDQIADAKLSGGIGATLVAIDAALS 251 Query: 234 K 234 + Sbjct: 252 R 252 >UniRef50_C3WP91 SIR2 family protein n=9 Tax=Fusobacterium RepID=C3WP91_9FUSO Length = 253 Score = 215 bits (548), Expect = 1e-54, Method: Composition-based stats. Identities = 73/241 (30%), Positives = 118/241 (48%), Gaps = 22/241 (9%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWE-----EHRVEDVATPEGFDRDPELVQAFYN 56 ++ TGAG+S +SG+++FR DGL+ ++R E+V + + F + F Sbjct: 27 NSKYLVFFTGAGVSTDSGLKSFRGKDGLYSTLYKGKYRPEEVLSSDFFYSHRNI---FME 83 Query: 57 ARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKV 116 +L I+PN HLALA+L+ +G ++TQNID+LH+ AGN NV+ +HG L + Sbjct: 84 YVENELNINGIKPNKGHLALAELE-RIGLLKAVITQNIDDLHQVAGNKNVLELHGSLKRW 142 Query: 117 RCSQSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMADIFI 174 C + G+ D C+ +RP V +GE ++E L AD I Sbjct: 143 YCLECGKTADNNFS---------CECGGIVRPDVTLYGENLNQAVVNEAIYQLEQADTLI 193 Query: 175 AIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLK 234 GTS VYPAA ++ K G + V +N E +Q +E + + + + + + Sbjct: 194 VAGTSLTVYPAAYYLRYFK--GKNLVIINNENTQYDSEASLVLNSNFADTMDKVINIIKM 251 Query: 235 G 235 G Sbjct: 252 G 252 >UniRef50_B9E751 Putative uncharacterized protein n=1 Tax=Macrococcus caseolyticus JCSC5402 RepID=B9E751_MACCJ Length = 243 Score = 215 bits (548), Expect = 1e-54, Method: Composition-based stats. Identities = 68/235 (28%), Positives = 111/235 (47%), Gaps = 14/235 (5%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEE-----HRVEDVATPEGFDRDPELVQAFYN 56 + +++ GAG+S ESGI FR+ADG++ + H E++ + + F++ P+ F+ Sbjct: 13 KSEKIVFFGGAGVSTESGIPDFRSADGIFMQETSIEHSPEEIISIDFFNKYPKQYFKFH- 71 Query: 57 ARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKV 116 +L P +PN AH + KL+ G +VTQNID LH+ AGN+ V+ +HG + Sbjct: 72 --FDKLVYPHAKPNIAHRFITKLEQQ-GKDVTVVTQNIDGLHQSAGNSKVLELHGNVQTN 128 Query: 117 RCSQSGQVLDWTGDVTPED-KCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMADIF 173 C+ +V +D C +RP +V +GE + E A+ AD+ Sbjct: 129 YCTHCKKVYQLEDISMDKDGIPRCLHDGHIIRPDIVMYGEALNSSVITEAITAIQNADMM 188 Query: 174 IAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEF 228 I GTS VYPA+ FV +G +N + A + +V+ Sbjct: 189 IIAGTSLVVYPASTFVDFF--NGETLAVINKTSLRTVRSDALIFEDYIGEVLNAI 241 >UniRef50_Q5KZE8 NAD-dependent deacetylase 2 n=8 Tax=Bacteria RepID=NPD2_GEOKA Length = 247 Score = 215 bits (547), Expect = 1e-54, Method: Composition-based stats. Identities = 65/237 (27%), Positives = 106/237 (44%), Gaps = 5/237 (2%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDV-ATPEGFDRDPELVQAFYNARRR 60 E + VLTGAG+S ESGI FR+ +GL+ + + + + +DP + Sbjct: 13 EANTIAVLTGAGMSTESGIPDFRSENGLYAQEDNVEYYLSEYYYKKDPVDFWRRFKRMFS 72 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 PN H L L++ +G ++TQNID LH +AG+TNVI +HG L C Sbjct: 73 LKMMGGFAPNDGHRFLRWLEE-MGKTVTILTQNIDGLHTKAGSTNVIELHGTLQTATCPS 131 Query: 121 SGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSG 180 G D + + + C + ++P VV FG + M+E + A + +D+ +A+GTS Sbjct: 132 CGNKYDLSF-INRHEVPRCEKCQTIVKPDVVLFGGLVPRMEEAFAAAAASDLLLAMGTSL 190 Query: 181 HVYPAAGFVHEAKLHGA--HTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKG 235 V P V +N +++ F YG + V +++ Sbjct: 191 EVAPVNQIPFYVAAESPATRKVLINKTATRMDGMFDLVIYGGIGKTVASVRKQIQAE 247 >UniRef50_D1N1D6 Silent information regulator protein Sir2 n=1 Tax=Victivallis vadensis ATCC BAA-548 RepID=D1N1D6_9BACT Length = 248 Score = 214 bits (546), Expect = 2e-54, Method: Composition-based stats. Identities = 69/236 (29%), Positives = 109/236 (46%), Gaps = 14/236 (5%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGL----WEEHRVEDVATPEGFDRDPELVQAFYNA 57 E R L TGAGIS SGIR FR +G+ W VE++ + + F +P L FY Sbjct: 11 ESRRTLAFTGAGISTLSGIRDFRGKNGVYLEPWHGKSVEEILSLDCFLAEPAL---FYGW 67 Query: 58 RRRQLQQ-PEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKV 116 L + E P A H ALA L+ + G + TQNID LH++AG+ +V +HG + Sbjct: 68 AAEFLYRLEEFHPAAVHRALAGLEQS-GLLRGVYTQNIDLLHQQAGSRHVYELHGSPARH 126 Query: 117 RCSQSGQVLDWTGDVTPE--DKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMADI 172 C + + + K C ++P +V++GE +++ + + A++ Sbjct: 127 HCLKCRKQFGYAEIAPLVLAGKVPRCGCGGLVKPDIVFYGENLDEALLNQAFADMEKAEL 186 Query: 173 FIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEF 228 + +G+S V PAA A G V +N +P+ + A + Y V E Sbjct: 187 VLVLGSSLTVQPAASLPMAANYGGGKIVIVNAQPTPLDRYAALR-YDDLQSVFEEL 241 >UniRef50_O96505 SIR2 n=15 Tax=Arthropoda RepID=O96505_DROME Length = 823 Score = 214 bits (546), Expect = 2e-54, Method: Composition-based stats. Identities = 60/269 (22%), Positives = 96/269 (35%), Gaps = 44/269 (16%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEH--------RVEDVATPEGFDRDPELVQA 53 + +++VLTGAG+S GI FR+ +G++ + + F RDP + Sbjct: 218 KSQKIIVLTGAGVSVSCGIPDFRSTNGIYARLAHDFPDLPDPQAMFDINYFKRDP---RP 274 Query: 54 FYNARRRQLQQP-EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGE 112 FY R + QP+ H + L+ G TQNID L AG VI HG Sbjct: 275 FYKFAREIYPGEFQFQPSPCHRFIKMLETK-GKLLRNYTQNIDTLERVAGIQRVIECHGS 333 Query: 113 LLKVRCSQSGQVLD---WTGDVTPEDKCHCCQF------------------------PAP 145 C++ + D+ + C Q Sbjct: 334 FSTASCTKCRFKCNADALRADIFAQRIPVCPQCQPNKEQSVDASVAVTEEELRQLVENGI 393 Query: 146 LRPHVVWFGEMPLGMDEIYMALSM--ADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELN 203 ++P +V+FGE MA D+ I IG+S V P A + +N Sbjct: 394 MKPDIVFFGEGLPDEYHTVMATDKDVCDLLIVIGSSLKVRPVAHIPSSIPAT-VPQILIN 452 Query: 204 LEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 E +F + G + ++ + +L Sbjct: 453 REQLHH-LKFDVELLGDSDVIINQICHRL 480 >UniRef50_C4QC33 Chromatin regulatory protein sir2, putative n=1 Tax=Schistosoma mansoni RepID=C4QC33_SCHMA Length = 305 Score = 214 bits (544), Expect = 3e-54, Method: Composition-based stats. Identities = 80/263 (30%), Positives = 115/263 (43%), Gaps = 34/263 (12%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 + VL TGAGISAES + TFR + W +D+ATP+ F +P LV FY+ R Sbjct: 42 KSHNVLAFTGAGISAESHVPTFRRSGESWRNFHTQDLATPDAFHSNPGLVWEFYHYCREV 101 Query: 62 LQQPEIQPNAAHLALAKLQDAL---GDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRC 118 ++ PNA HLALA + G F ++TQN+D LH +AG NV+ +HG L K RC Sbjct: 102 VRSR--CPNAGHLALAHAEKQYTECGRSFFIITQNVDGLHAKAGCVNVLELHGNLYKTRC 159 Query: 119 SQSGQVL---------------------DWTGDVTPEDKCHCCQ------FPAPLRPHVV 151 + + + C LRPHVV Sbjct: 160 LECNDIRVNFDKPICAALLGRGSPIIENIPCKPIPLSQLPRCQNRINNNICGGLLRPHVV 219 Query: 152 WFGEMPLG--MDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQV 209 WFGE + + + AD+ + +G S VYP A F G E+N+E + Sbjct: 220 WFGENLEPHILSKAGEIVQKADVCLVVGASSAVYPVASFTRSLANRGIPVAEINVEVTPA 279 Query: 210 GNEFAEKYYGPASQVVPEFVEKL 232 + + G + V+P+ + L Sbjct: 280 THLLQYHFQGKSGDVLPKLFDSL 302 >UniRef50_C6XKE4 Silent information regulator protein Sir2 n=1 Tax=Hirschia baltica ATCC 49814 RepID=C6XKE4_HIRBI Length = 249 Score = 213 bits (543), Expect = 3e-54, Method: Composition-based stats. Identities = 102/238 (42%), Positives = 143/238 (60%), Gaps = 5/238 (2%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 ++ V++LTGAG+S ESGI +R D +W +E+ P+ F ++PELV FYN RR Sbjct: 4 VQFKHVVLLTGAGVSVESGIPVYRNEDEIWTRKEMENFFRPDTFRKNPELVHDFYNKRRM 63 Query: 61 QLQQPEIQPNAAHLALAKLQDAL---GDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVR 117 L +IQPN H +A LQD L + ++T+N+D+LHE+AG T+VIH+ G+L Sbjct: 64 DL--KKIQPNKTHCHIAYLQDQLLGSRTKLTIITKNVDDLHEKAGTTDVIHILGDLNSAF 121 Query: 118 CSQSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIG 177 C+ + GD+ + C C+ +RP +VW GE P MD+I AL D+F++IG Sbjct: 122 CTICNIRIKCMGDLITQTICSNCKNKKTMRPDIVWAGEKPYHMDKIQAALDECDLFVSIG 181 Query: 178 TSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKG 235 TSG VYP A FV+ AK GA TVELN +PS F YGPAS +VP +V+ + G Sbjct: 182 TSGSVYPTADFVNLAKKTGAVTVELNQKPSANATSFDHTNYGPASTIVPFWVDTFIHG 239 >UniRef50_C6AKY4 Transcriptional regulator, Sir2 family n=5 Tax=Proteobacteria RepID=C6AKY4_AGGAN Length = 232 Score = 213 bits (543), Expect = 3e-54, Method: Composition-based stats. Identities = 98/234 (41%), Positives = 137/234 (58%), Gaps = 10/234 (4%) Query: 6 VLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQP 65 +VL+GAGISAESGI T+RA DGLW H++E+V TPE R+ + V FYN RRR Sbjct: 5 CVVLSGAGISAESGIPTYRAEDGLWAGHKIEEVCTPEALQRNRKKVLDFYNERRRNCSA- 63 Query: 66 EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRC-SQSGQV 124 QPNAAH AL +L+ G ++TQN+D+LHERAG+ NV+H+HGEL K R + Sbjct: 64 -AQPNAAHKALVELEQ--GYNVQIITQNVDDLHERAGSANVLHLHGELNKARSGFDPDYI 120 Query: 125 LDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGHVYP 184 + G+ + +DK P+RPH+V+FGE ++ +S AD+ + IGTS VYP Sbjct: 121 VPCFGEQSVDDKDPN---GHPMRPHIVFFGENVPMLEPAIDLVSQADVVLVIGTSLQVYP 177 Query: 185 AAGFVHEAKLHGAHTVELNLEP-SQVGNEFAEKYYGPASQVVPEFVEKLLKGLK 237 A G V+EA + A ++ P + E A + VP+ V +LL +K Sbjct: 178 ANGLVNEAPKN-AQIYLIDPNPNTGFIPRPVETVKMKAGEGVPKVVAELLGKVK 230 >UniRef50_Q8CNF4 NAD-dependent deacetylase n=64 Tax=Staphylococcus RepID=NPD_STAES Length = 246 Score = 213 bits (543), Expect = 4e-54, Method: Composition-based stats. Identities = 68/235 (28%), Positives = 114/235 (48%), Gaps = 14/235 (5%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHR-----VEDVATPEGFDRDPELVQAFYN 56 +++ TGAG+S SGI FR+ GL++E E + + + + E FY+ Sbjct: 15 NSNQIVFFTGAGVSVASGIPDFRSMGGLYDEISKDGQSPEYLLSIDHLHDNKESFINFYH 74 Query: 57 ARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKV 116 R L + +PN H +A+L++ ++TQNID LHE AG+ N+ +HG L + Sbjct: 75 ER---LLIADKKPNIVHQWIAQLENQQ-KSLGVITQNIDGLHEDAGSHNIDELHGTLNRF 130 Query: 117 RCSQSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMADIFI 174 C + + +T K +C + +RP +V +GEM + + + AD I Sbjct: 131 YCINCYEEYSKSYVMTHHLK-YCEKCGNVIRPDIVLYGEMLNQKTVFKALDKIQHADTLI 189 Query: 175 AIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFV 229 +G+S V PAAGFV E K G + V +N + + + + + + V+ E V Sbjct: 190 VLGSSLVVQPAAGFVSEFK--GDNLVIINRDATPYDHTASLVIHDDMTSVIEEIV 242 >UniRef50_A7EC18 Putative uncharacterized protein n=1 Tax=Sclerotinia sclerotiorum 1980 UF-70 RepID=A7EC18_SCLS1 Length = 446 Score = 212 bits (541), Expect = 6e-54, Method: Composition-based stats. Identities = 60/248 (24%), Positives = 90/248 (36%), Gaps = 23/248 (9%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAA-DGLWEEHRVEDV------ATPEGFDRDPELVQAF 54 + ++VLTGAGIS +GI FR+ G++ D+ + F +P F Sbjct: 35 QAKNIVVLTGAGISTSAGIPDFRSPETGIYANLAELDLPYAEAVFDIDFFRENPA---PF 91 Query: 55 YNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGE 112 Y + L + P +H +A L + G +L TQNID L RAG + VI HG Sbjct: 92 YVLAKE-LYPGQFYPTISHAFVA-LIEKKGLLRMLFTQNIDCLERRAGVSSEKVIEAHGS 149 Query: 113 LLKVRCSQSGQVLDWTGDVTPED-----KCHCCQFPAPLRPHVVWFGEMPLGMDEIYMAL 167 RC C Q ++P +V+FGE + + Sbjct: 150 FATQRCIDCKTEYPDDMMKKAIQEGDPATCLVPQCGGLVKPDIVFFGEQLPEAFHSHKMI 209 Query: 168 -SMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQ--VGNEFAEKYYGPASQV 224 + AD+ I +GTS V P A + N+ G Sbjct: 210 PATADLIIVMGTSLSVQPFAMLPSLPADT-VPRLLFNMISVGDFGSRLDDVVVLGDCDTG 268 Query: 225 VPEFVEKL 232 V + + L Sbjct: 269 VRKLADAL 276 >UniRef50_Q8REC3 NAD-dependent deacetylase n=8 Tax=Fusobacterium RepID=NPD_FUSNN Length = 252 Score = 212 bits (541), Expect = 7e-54, Method: Composition-based stats. Identities = 69/238 (28%), Positives = 115/238 (48%), Gaps = 22/238 (9%) Query: 4 PRVLVLTGAGISAESGIRTFRAADGLWE-----EHRVEDVATPEGFDRDPELVQAFYNAR 58 ++ GAG S +SG++ FR DGL++ ++R E+V + + F ++ F Sbjct: 20 KYLVFFGGAGTSTDSGVKDFRGKDGLYKTLYKDKYRPEEVLSSDFFYSHRDI---FMKYV 76 Query: 59 RRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRC 118 ++L ++PN H+AL +L+ +G ++TQNID+LH+ +GN NV+ +HG L + C Sbjct: 77 EKELNIKGLKPNKGHMALVELE-KIGILKAVITQNIDDLHQVSGNKNVLELHGSLKRWYC 135 Query: 119 SQSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMADIFIAI 176 G+ D C+ +RP V +GE ++E L AD I Sbjct: 136 LSCGKTADRNFS---------CECGGVVRPDVTLYGENLNQSVVNEAIYQLEQADTLIVA 186 Query: 177 GTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLK 234 GTS VYPAA ++ G + + +N +Q E + S V+ V++L K Sbjct: 187 GTSLTVYPAAYYLRYF--RGKNLIIINDMDTQYDGEASLVIKDNFSYVMDRVVKELKK 242 >UniRef50_B2ARI4 Predicted CDS Pa_4_7390 (Fragment) n=1 Tax=Podospora anserina RepID=B2ARI4_PODAN Length = 344 Score = 212 bits (540), Expect = 9e-54, Method: Composition-based stats. Identities = 88/277 (31%), Positives = 125/277 (45%), Gaps = 47/277 (16%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 ++ R+L + GAG+SA SG+ TFR A GLW H D+ATPE FD DP LV FY RR Sbjct: 58 LKSNRILAVCGAGLSAASGLPTFRGAGGLWRNHNAVDLATPEAFDADPGLVWLFYAYRRH 117 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERA--GNTNVIHMHGELLKVRC 118 +PN AH ALA+L F ++QN+DNLH RA + + +HG L ++C Sbjct: 118 M--ALTAKPNPAHYALAELARKRP-GFKCLSQNVDNLHVRANHPSDQLSLLHGSLFTLKC 174 Query: 119 SQSGQVLDWTGDVTPEDK--------------------------------CHCCQFPAPL 146 + + HC L Sbjct: 175 TTCSWKDLYNIADPLCPALAPAAESNPDPTKPLPLLDPAQPLAEIKESELPHCPDCKTEL 234 Query: 147 -RPHVVWFGEMPLG--MDEIYMALSM--ADIFIAIGTSGHVYPAAGFVHEAKLHGAH-TV 200 RP VVWFGEM +D+I + D+ + +GTS VYPAAG+ A+ G V Sbjct: 235 QRPGVVWFGEMLDEDMLDDIEEWIEKEPVDMVLVVGTSSAVYPAAGYAERARTKGRTSVV 294 Query: 201 ELNLEPSQVG----NEFAEKYYGPASQVVPEFVEKLL 233 +NLE ++ + + G AS ++PE + ++ Sbjct: 295 TVNLEITEEDWGRMRKGDFGFEGDASLLLPELLRPVI 331 >UniRef50_C0S0X1 NAD-dependent deacetylase sirtuin-2 n=3 Tax=Paracoccidioides brasiliensis RepID=C0S0X1_PARBP Length = 447 Score = 212 bits (539), Expect = 1e-53, Method: Composition-based stats. Identities = 62/244 (25%), Positives = 93/244 (38%), Gaps = 21/244 (8%) Query: 4 PRVLVLTGAGISAESGIRTFRAAD-GLWEEH------RVEDVATPEGFDRDPELVQAFYN 56 R++VLTGAGIS +GI FR+ D G++ E V F ++P + FY+ Sbjct: 36 RRIVVLTGAGISTAAGIPDFRSPDTGIYANLARLNLPHPEAVFDISYFRKNP---RPFYS 92 Query: 57 ARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNT--NVIHMHGELL 114 + +P AH + L D G L TQNID L +AG ++ HG Sbjct: 93 LSKEMF-PGRYRPTIAHTFIKLLYDK-GLLLKLFTQNIDCLERQAGVPGGMIVEAHGSYA 150 Query: 115 KVRCSQSGQVLD---WTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALS-MA 170 C + D C + ++P +V+FGE + L+ A Sbjct: 151 THSCIDCKSPYPDDLMRKAIESNDIPLCLKCCGFVKPDIVFFGESLPESFFMNRTLTTAA 210 Query: 171 DIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQ--VGNEFAEKYYGPASQVVPEF 228 ++ I +GTS V P A K G + +NL G V + Sbjct: 211 ELCIIMGTSLTVQPFASLPSLCKE-GVPRLLINLNRVGGLGSRPDDVLLLGECDDGVLKL 269 Query: 229 VEKL 232 + L Sbjct: 270 ADAL 273 >UniRef50_Q8A3H9 NAD-dependent deacetylase n=29 Tax=Bacteria RepID=NPD_BACTN Length = 234 Score = 211 bits (538), Expect = 1e-53, Method: Composition-based stats. Identities = 98/241 (40%), Positives = 135/241 (56%), Gaps = 18/241 (7%) Query: 4 PRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQ 63 ++VLTGAG+SAESGI TFR A GLW+++ VE VATPEG+ RDP LV FYNARR+QL Sbjct: 2 KNLVVLTGAGMSAESGISTFRDAGGLWDKYPVEQVATPEGYQRDPALVINFYNARRKQLL 61 Query: 64 QPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQ 123 E++PN H LA+L+ ++TQN+DNLHERAG+++++H+HGEL KV Sbjct: 62 --EVKPNRGHELLAELEK--NFNVTVITQNVDNLHERAGSSHIVHLHGELTKV----CSS 113 Query: 124 VLDWTGDVTPEDKCHCCQ--------FPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIA 175 + E K + LRP +VWFGE ++ + ADIF+ Sbjct: 114 RDPYNPHYIKELKPEEYEVKMGDKAGDGTQLRPFIVWFGEAVPEIETAVRYVEKADIFVI 173 Query: 176 IGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQ-VGNEFAEKYYGPASQVVPEFVEKLLK 234 IGTS +VYPAAG +H GA ++ +P + AS+ V E + L+ Sbjct: 174 IGTSLNVYPAAGLLHYVP-RGAEVYLIDPKPVDTHTSRSIHVLRKGASEGVEELKQLLIP 232 Query: 235 G 235 Sbjct: 233 A 233 >UniRef50_D2VWA2 Silent information regulator family protein n=1 Tax=Naegleria gruberi RepID=D2VWA2_NAEGR Length = 297 Score = 211 bits (538), Expect = 2e-53, Method: Composition-based stats. Identities = 80/258 (31%), Positives = 119/258 (46%), Gaps = 24/258 (9%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWE----EHRVEDVATPEGFDRDPELVQAFYNA 57 + RV+V +GAG+SAESGI TFR GLW + + TP G++ P++ Y Sbjct: 25 KARRVVVFSGAGMSAESGIDTFRGGGGLWTGLMGKLFLAYGGTPFGWNITPQICWGQY-I 83 Query: 58 RRRQLQQPEIQPNAAHLALAKLQDA-LGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKV 116 +R + PN H ALAKL+ GD ++TQN+D LH+RAG+T+V +HG +++ Sbjct: 84 KRFYGPIAKADPNNGHFALAKLEQEVFGDYMEVITQNVDGLHQRAGSTHVYEVHGTVMRH 143 Query: 117 RCSQSGQVLDWTGDV------------TPEDKCHCCQFPAPLRPHVVWFGEMPLGMD--- 161 C + D+ KC + LRP V F E Sbjct: 144 CCIAERHIFDFDEYWGEENDEKKMDLPDKSPKCKHPGCNSTLRPDCVLFTEALPMDQWEP 203 Query: 162 --EIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKY-Y 218 + D+ I +GTS VYPAA A GAH +E NLE + + Sbjct: 204 SFHAVDRMRKGDVMICVGTSAKVYPAASLPGRAARRGAHLIEFNLEETDYNQLPNYIFVK 263 Query: 219 GPASQVVPEFVEKLLKGL 236 GP+ Q +P V+++++ Sbjct: 264 GPSGQTLPTIVDRVIELR 281 >UniRef50_C4Q5J6 Chromatin regulatory protein sir2, putative n=2 Tax=Schistosoma RepID=C4Q5J6_SCHMA Length = 618 Score = 211 bits (537), Expect = 2e-53, Method: Composition-based stats. Identities = 58/248 (23%), Positives = 95/248 (38%), Gaps = 21/248 (8%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHR--------VEDVATPEGFDRDPELVQAF 54 +LV+TGAGIS GI FR+ DG++ + + F R+P F Sbjct: 154 CTSILVITGAGISVSCGIPDFRSRDGIYARLSRDYPDLSSPQAMFDMSYFKRNPIPFFKF 213 Query: 55 YNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELL 114 ++L + P+ H +A L+ TQNID L + AG T +I HG Sbjct: 214 ----AKELFPGQFSPSITHRMIALLESKD-KLLRNYTQNIDTLEQAAGITRLIQCHGSFA 268 Query: 115 KVRCSQSGQVLDWTGDVTPEDKCHCCQF----PAPLRPHVVWFGEMPLG--MDEIYMALS 168 C+ + + L+P +V+FGE D + + Sbjct: 269 SATCTNCKLKVSSDFIKEAIFTQSIPRCTNSSYGVLKPDIVFFGEGLSNEFHDSLSNDIK 328 Query: 169 MADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEF 228 D+ + IG+S V P + + A + +N EP ++F + G +V E Sbjct: 329 QTDLVLVIGSSLKVRPVSHIPN-AVPRQVPQILINREPLS-NHDFDVELLGDCDVIVSEL 386 Query: 229 VEKLLKGL 236 +L + Sbjct: 387 CHRLGWEV 394 >UniRef50_UPI00015B57C0 PREDICTED: similar to GA18743-PA n=1 Tax=Nasonia vitripennis RepID=UPI00015B57C0 Length = 871 Score = 211 bits (537), Expect = 2e-53, Method: Composition-based stats. Identities = 59/272 (21%), Positives = 97/272 (35%), Gaps = 42/272 (15%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEH--------RVEDVATPEGFDRDPELVQA 53 ++VLTGAG+S GI FR+ DG++ + + F +DP Sbjct: 203 NSKNIIVLTGAGVSVSCGIPDFRSRDGIYSRLAQDFPDLPDPQAMFDINYFSQDPRPFFK 262 Query: 54 FYNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGEL 113 F R++ + +P+ H + L+ +QNID L AG N+I HG Sbjct: 263 F----AREIYPGQFKPSPCHQFIKMLEKQK-KLLRNYSQNIDTLERVAGINNLIECHGSF 317 Query: 114 LKVRCSQSGQVL---DWTGDVTPEDKCHCCQFPA----------------------PLRP 148 C++ + D ++ + C + ++P Sbjct: 318 ATASCTKCKYQVKSDDVKAEIFAQTIPMCPKCQEQSLPSITDPTSSDNYRDIVAQGVMKP 377 Query: 149 HVVWFGEMPLG--MDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEP 206 +V+FGE D + + D+ I IG+S V P A H + +N E Sbjct: 378 DIVFFGEGLPDAFHDAMASDKDVCDLLIVIGSSLKVRPVALIPSSIPSH-VPQILINRES 436 Query: 207 SQVGNEFAEKYYGPASQVVPEFVEKLLKGLKA 238 Q EF + G V+ + L K Sbjct: 437 LQH-LEFDVELLGDGDVVINQLCHMLDGSFKE 467 >UniRef50_C8W9D8 Silent information regulator protein Sir2 n=2 Tax=Atopobium RepID=C8W9D8_ATOPD Length = 283 Score = 210 bits (536), Expect = 2e-53, Method: Composition-based stats. Identities = 65/276 (23%), Positives = 100/276 (36%), Gaps = 55/276 (19%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEE------------------------------ 32 ++ GAG+S ESGI FR +GL+ + Sbjct: 14 SDNIVFFGGAGVSTESGIPDFRGTNGLYRQGGIKIENMTIGLGQDGYDMGKETCDLGNGI 73 Query: 33 -----------------HRVEDVATPEGFDRDPELVQAFYNARRRQLQQPEIQPNAAHLA 75 +E++ + + F P ++ E QPN AH Sbjct: 74 TVDPDNEESFAYSKAPDFTLEEIFSLDVFLDYPAAYYTYFRNSHHL---GEAQPNIAHKW 130 Query: 76 LAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVLDWTGDVTPED 135 LA L+ A G +VTQNID LH+ AG+ V +HG + C + G V Sbjct: 131 LAALE-AEGKLRAVVTQNIDGLHQAAGSKRVFELHGNETRFYCPECGHVYTLDQIEEQSS 189 Query: 136 KCHCCQFPAPLRPHVVWFGEMP--LGMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAK 193 CQ A +RP +V++GE + A+S A++ I G+S V PA G + Sbjct: 190 VVPLCQCGAVIRPDIVFYGEGLNMDTVYGALNAISQAEVLIVAGSSLVVQPAVGLLDY-- 247 Query: 194 LHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFV 229 G V +N +P+ V+ + Sbjct: 248 YEGNKMVIINDQPTPYDGRANLVIRDRIGAVIEHLL 283 >UniRef50_Q9FE17 Sir2-like protein n=13 Tax=Viridiplantae RepID=Q9FE17_ARATH Length = 473 Score = 210 bits (534), Expect = 5e-53, Method: Composition-based stats. Identities = 58/241 (24%), Positives = 94/241 (39%), Gaps = 29/241 (12%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 + ++V TGAGIS GI FR G+W R + + Sbjct: 43 KSKHLVVFTGAGISTSCGIPDFRGPKGIWTLQREGK------------------DLPKAS 84 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELLKVRCS 119 L P+ H+AL +L+ A G +++QN+D LH R+G + +HG+ C Sbjct: 85 LPFHRAMPSMTHMALVELERA-GILKFVISQNVDGLHLRSGIPREKLSELHGDSFMEMCP 143 Query: 120 QSGQVLDWTGDVTPE------DKCHCCQFPAPLRPHVV-WFGEMPL-GMDEIYMALSMAD 171 G +V KC + A L+ V+ W +P +D AD Sbjct: 144 SCGAEYLRDFEVETIGLKETSRKCSVEKCGAKLKDTVLDWEDALPPKEIDPAEKHCKKAD 203 Query: 172 IFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEK 231 + + +GTS + PA + G V +NL+ + + +G +VV +E Sbjct: 204 LVLCLGTSLQITPACNLPLKCLKGGGKIVIVNLQKTPKDKKANVVIHGLVDKVVAGVMES 263 Query: 232 L 232 L Sbjct: 264 L 264 >UniRef50_A9BHU8 Silent information regulator protein Sir2 n=3 Tax=Bacteria RepID=A9BHU8_PETMO Length = 256 Score = 210 bits (534), Expect = 5e-53, Method: Composition-based stats. Identities = 54/240 (22%), Positives = 100/240 (41%), Gaps = 16/240 (6%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEE---HRVEDVATPEGFDRDPELVQAFYNAR 58 + VL+GAG+S +GI FR +G++ + E + + F DP L F+ Sbjct: 14 NSNSIAVLSGAGMSTNAGIPDFRGPNGIYTKANIENPERIFDLDYFYLDPSLFYKFHKKF 73 Query: 59 RRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRC 118 + + +P H L +L+ G +VTQNID+LH++AG+ V +HG K C Sbjct: 74 LEYIT--KAEPTFTHKFLVQLE-KEGKLKGIVTQNIDSLHQKAGSKKVYEIHGGCWKNYC 130 Query: 119 SQSGQVL---DWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIA 175 ++ + + + E C ++P +V+FGE + E + + +++ + Sbjct: 131 TKCKRKYSQEEILEKMNNEVVPKCDNCGGVIKPDIVFFGEPVKYLTESEILMKNSELVLV 190 Query: 176 IGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQV----GNEFAEKYYGPASQVVPEFVEK 231 +G+S V PAA K + +N + A + ++ Sbjct: 191 LGSSLAVIPAAMLPSLTK---GKIIVVNKGEISEMYLPPQKVALIVNEELDTFFMQVAKE 247 >UniRef50_Q6BPH5 DEHA2E13596p n=4 Tax=Saccharomycetaceae RepID=Q6BPH5_DEBHA Length = 573 Score = 209 bits (532), Expect = 8e-53, Method: Composition-based stats. Identities = 63/267 (23%), Positives = 98/267 (36%), Gaps = 38/267 (14%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEH------RVEDVATPEGFDRDPELVQAFY 55 + ++LV+TGAGIS GI FR++ G + + ++V + F DP + FY Sbjct: 259 KAKKILVVTGAGISTSLGIPDFRSSKGFYSQLQYLGLSDPQEVFDLDFFHSDPNI---FY 315 Query: 56 NARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGEL 113 + + PE H + LQ+ G TQNIDNL G +I HG Sbjct: 316 SIAY-MILPPEKSYTPLHAFIKLLQNK-GKLLRNYTQNIDNLESNVGIKPEKLIQCHGSF 373 Query: 114 LKVRCSQSGQVL---DWTGDVTPEDKCHCCQFPA------------------PLRPHVVW 152 C + + ++ +C + ++P + + Sbjct: 374 ATASCVTCKYQVKGEKIYPKIREKEVPYCPKCKNARKILLNKEDAYVPESYGVMKPDITF 433 Query: 153 FGEMPL-GMDEIYM-ALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVG 210 FGE + L D+ I+IGTS V P A V H V +N +P Sbjct: 434 FGEPLPTRFHNMIRQDLMECDLLISIGTSLKVSPVADIVERIPEH-IPQVLINKDPIDHC 492 Query: 211 NEFAEKYYGPASQVVPEFVEKLLKGLK 237 N F G ++L KG + Sbjct: 493 N-FDVSILGYCDDTANYLCKRLGKGWE 518 >UniRef50_Q9Y6E7 NAD-dependent ADP-ribosyltransferase sirtuin-4 n=33 Tax=Deuterostomia RepID=SIRT4_HUMAN Length = 314 Score = 209 bits (532), Expect = 8e-53, Method: Composition-based stats. Identities = 66/259 (25%), Positives = 104/259 (40%), Gaps = 34/259 (13%) Query: 3 KPRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 R+LV+TGAGIS ESGI +R+ GL+ + + P + + Sbjct: 54 SKRLLVMTGAGISTESGIPDYRSEKVGLYARTDRRPIQHGDFVRSAPIRQRYWARNFVGW 113 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 Q QPN AH AL+ + LG + LVTQN+D LH +AG+ + +HG + +V C Sbjct: 114 PQFSSHQPNPAHWALSTWE-KLGKLYWLVTQNVDALHTKAGSRRLTELHGCMDRVLCLDC 172 Query: 122 GQVLDW------------------------------TGDVTPEDKCHCCQFPAPLRPHVV 151 G+ V C Q L+P VV Sbjct: 173 GEQTPRGVLQERFQVLNPTWSAEAHGLAPDGDVFLSEEQVRSFQVPTCVQCGGHLKPDVV 232 Query: 152 WFGE--MPLGMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQV 209 +FG+ P +D ++ + AD + +G+S VY F+ A LN+ P++ Sbjct: 233 FFGDTVNPDKVDFVHKRVKEADSLLVVGSSLQVYSGYRFILTAWEKKLPIAILNIGPTRS 292 Query: 210 GNEFAEKYYGPASQVVPEF 228 + K +++P Sbjct: 293 DDLACLKLNSRCGELLPLI 311 >UniRef50_Q607X6 NAD-dependent deacetylase n=2 Tax=Gammaproteobacteria RepID=NPD_METCA Length = 255 Score = 208 bits (531), Expect = 8e-53, Method: Composition-based stats. Identities = 85/245 (34%), Positives = 117/245 (47%), Gaps = 13/245 (5%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAA-DGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 + + V TGAG+SAESGI TFR A G WE + +A+PEGF DP LV +Y RR Sbjct: 13 DARHIAVFTGAGVSAESGIPTFRDALTGFWENYDASTLASPEGFAADPALVWGWYEWRRT 72 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 ++ +PN AH A+A L L+TQN+D+LHERAG+ + I +HG L RCS Sbjct: 73 RVL--RAEPNPAHYAIAALAADCPRL-TLITQNVDDLHERAGSADPIRLHGSLHHPRCSA 129 Query: 121 SGQVLDWTGDVTPE-------DKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMAL--SMAD 171 + E D C + AP+RP VVW GE D Sbjct: 130 CEAPYRLPPGIPDEPEGGRRVDPPRCARCGAPVRPGVVWLGENLPQAAWDAARQAAEDCD 189 Query: 172 IFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEK 231 + +IGTS V+PAA GA V++N + + G A +V+P ++ Sbjct: 190 LMFSIGTSALVWPAAQLPALVARRGATVVQVNPAETALDGHAGYNLRGAAGKVMPLLLQA 249 Query: 232 LLKGL 236 L + Sbjct: 250 LRRSR 254 >UniRef50_D1B8J6 Silent information regulator protein Sir2 n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B8J6_THEAS Length = 246 Score = 208 bits (531), Expect = 1e-52, Method: Composition-based stats. Identities = 62/243 (25%), Positives = 103/243 (42%), Gaps = 16/243 (6%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEH--RVEDVATPEGFDRDPELVQAFYNARRR 60 R++VLTGAGIS SGI FR +G++ + E + + F +P F+ Sbjct: 13 ARRIVVLTGAGISTASGIPDFRGPNGIYRQLGAEAERIFDIDHFMVNPSTFYGFHRRFLE 72 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 ++ ++P+ AH +AKL++ ++TQN+D LH+RAG+ NVI +HG + + C Sbjct: 73 MVEA--VRPSFAHRFIAKLEET--KDLAVITQNVDGLHQRAGSRNVIEIHGGIGENSCLT 128 Query: 121 SGQVLDWTG--DVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGT 178 G+ + E + C ++PHVV+FGE +D + + +G+ Sbjct: 129 CGRTYSLGDLKAMMEEREVPLCSCGGLIKPHVVFFGEGVRDLDRCMELSRDCQVMLVVGS 188 Query: 179 SGHVYPAAGFVHEAKLHGAHTVELNLEPSQ---VGNEFAEKYYGPASQVVPEFVEKLLKG 235 S V PAA K ++ V ++ G Sbjct: 189 SLTVTPAASLPSLCK---GTLAVVSRGEIYTGHVRRPIDIMIEEDIDPFFMRLAAEM--G 243 Query: 236 LKA 238 LK Sbjct: 244 LKP 246 >UniRef50_Q5V4Q5 NAD-dependent deacetylase n=3 Tax=Halobacteriaceae RepID=NPD_HALMA Length = 260 Score = 208 bits (530), Expect = 1e-52, Method: Composition-based stats. Identities = 77/237 (32%), Positives = 105/237 (44%), Gaps = 9/237 (3%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQ-AFYNARRRQ 61 + LTGAG+S SGI +FR DG+WE H D D DP + R Sbjct: 26 AETAVALTGAGVSTASGIPSFRGDDGIWERHDPAD-FHRRRLDADPAGFWADRLSLREAI 84 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 + +PNAAH ALA +A G ++TQNID LH+ AG V+ +HG +V C Sbjct: 85 YGDIDPEPNAAHEALAA-LEADGHLDAVLTQNIDGLHDAAGTDRVVELHGTHRRVVCDDC 143 Query: 122 GQVLD----WTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMADIFIA 175 G D + D C RP VV FGE M+E +D+F+A Sbjct: 144 GHRRDAEVVFEQAAESSDLPPRCDCGGVYRPDVVLFGEPMPDVAMNEAQRLARDSDVFLA 203 Query: 176 IGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 +G+S V PA+ A + V +N E + A +QV+P VE+L Sbjct: 204 VGSSLSVQPASLLPKIAAEGDSTLVVVNYEETPRDASAAHVLRADVTQVLPAIVERL 260 >UniRef50_Q54GV7 NAD(+)-dependent deacetylase, silent information regulator protein family protein n=1 Tax=Dictyostelium discoideum RepID=Q54GV7_DICDI Length = 542 Score = 208 bits (530), Expect = 1e-52, Method: Composition-based stats. Identities = 54/248 (21%), Positives = 93/248 (37%), Gaps = 23/248 (9%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEE-------HRVEDVATPEGFDRDPELVQAFY 55 ++++TGAG+S GI FR+ G++E R E + +P F Sbjct: 300 SKNIVIITGAGVSVSCGIPDFRSKGGVYETIEKKYNLPRPESLFDIHYLRANPLPFFEF- 358 Query: 56 NARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGEL 113 +++ +P+ H + L D G TQNID L AG +++ HG Sbjct: 359 ---AKEIFPGNHKPSPTHSFIKLL-DEKGKLLRNYTQNIDTLEHVAGIDREKLVNCHGSF 414 Query: 114 LKVRCSQSGQVLD---WTGDVTPEDKCHCCQFPA---PLRPHVVWFGEMPLGMDE--IYM 165 C +D + + C Q ++P +V+FGE + + Sbjct: 415 STATCITCKLTVDGTTIRDTIMKMEIPLCQQCNDGQSFMKPDIVFFGENLPDRFDQCVLK 474 Query: 166 ALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVV 225 + D+ I +G+S V P + + +N E +EF Y G Q V Sbjct: 475 DVKDIDLLIVMGSSLQVQPVSLLPDIV-DKQIPQILINRELVAQPHEFDYVYLGDCDQFV 533 Query: 226 PEFVEKLL 233 + + K+ Sbjct: 534 QDLLNKVK 541 >UniRef50_A8NWP2 Putative uncharacterized protein n=1 Tax=Coprinopsis cinerea okayama7#130 RepID=A8NWP2_COPC7 Length = 315 Score = 208 bits (530), Expect = 1e-52, Method: Composition-based stats. Identities = 86/285 (30%), Positives = 122/285 (42%), Gaps = 61/285 (21%) Query: 2 EKPRVLVLTGAGISAESG----------------IRTFRAADGLWEEHRVEDVATPEGFD 45 ++ + GAG+SA SG I TFR A G+W ++ +ATPEGF Sbjct: 15 NAKNIIAVAGAGLSAASGKSGYYRFKWNLTTSQGIPTFRGAGGMWRKYDAMSLATPEGFA 74 Query: 46 RDPELVQAFYNARRRQLQQPEIQPNAAHLALAKLQD-------ALGDRFLLVTQNIDNLH 98 +P LV FY+ RR + ++ NAAHLALA A G F L+TQN+D L Sbjct: 75 DNPSLVWQFYHYRREAALKADV--NAAHLALASFSIPRIRHTVAPGSSFTLITQNVDGLS 132 Query: 99 ERA------GNTNV---------IHMHGELLKVRCSQSGQ-------------------- 123 RA G V I MHG L V+C+Q Sbjct: 133 PRAMKCVLQGWDGVTLPEDPPYLIEMHGRLFDVKCTQCDHVELDTSSPICEGLAGTEKLV 192 Query: 124 -VLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGHV 182 ++ E+ C + + RP VVWFGEMP + I + AD+ + +GTS V Sbjct: 193 EQAVLDPEIPEENLPRCKKCGSLARPGVVWFGEMPHDLPLIDTLVEKADLCLVVGTSSTV 252 Query: 183 YPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPE 227 YPAAG+ E +G N E + ++ + G + +P+ Sbjct: 253 YPAAGYASEVSANGGKVAVFNYERTMGDDDADFLFLGGCEETLPK 297 >UniRef50_C6Y0J4 Silent information regulator protein Sir2 n=1 Tax=Pedobacter heparinus DSM 2366 RepID=C6Y0J4_PEDHD Length = 227 Score = 208 bits (529), Expect = 2e-52, Method: Composition-based stats. Identities = 99/232 (42%), Positives = 132/232 (56%), Gaps = 9/232 (3%) Query: 4 PRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQ 63 RV++LT AGISAESG++TFR ADGLWE + + DVATPE + R+PELVQ FYN RR+ + Sbjct: 2 KRVVILTDAGISAESGLKTFRDADGLWEGYNIADVATPEAWKRNPELVQRFYNERRKSVI 61 Query: 64 QPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQ 123 E QPNAAH AL LQ ++TQNID+LHERAG NV+H+HG + + + S Sbjct: 62 --EAQPNAAHKALTLLQTKYN--VHIITQNIDDLHERAGAENVLHLHGIITRSQ-SDVDS 116 Query: 124 VLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGHVY 183 + + + C++ PLRPHVVWFGE + + ADIF IGTS VY Sbjct: 117 AVTYPIEGWEIGPSAVCEYGMPLRPHVVWFGENVPNLMPAAKICAKADIFAVIGTSLVVY 176 Query: 184 PAAGFVHEAKLHGAHTVELNLEPS-QVGNEFAEKYYGPASQVVPEFVEKLLK 234 PAAG +P+ ++ A+ VPE V++L+ Sbjct: 177 PAAGLTDYVPDTALKYAV---DPNIPQIKGNFKRIEKAATIGVPEMVKELMN 225 >UniRef50_C5CY53 Silent information regulator protein Sir2 n=1 Tax=Variovorax paradoxus S110 RepID=C5CY53_VARPS Length = 249 Score = 207 bits (528), Expect = 2e-52, Method: Composition-based stats. Identities = 81/231 (35%), Positives = 109/231 (47%), Gaps = 12/231 (5%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 R+ VL+GAG+S SGI T+R ADGLW + E RDP F+ RR Sbjct: 24 ARRIAVLSGAGLSKASGISTYRDADGLWMNQNALQFSHAEDLQRDPRRFTRFW--ARRLS 81 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG 122 QPN H ALA LQ L LVTQN+D L AG +V+ +HG L + RC G Sbjct: 82 TVEAAQPNPGHAALALLQ-RLRPATRLVTQNVDGLLSIAGGLDVLELHGSLRRWRCDHCG 140 Query: 123 QVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEM--PLGMDEIYMALSMADIFIAIGTSG 180 P C + + RP VV FGEM P + + +A +D+F+ +G++ Sbjct: 141 NR------RGPWPFHRCMRCASRARPDVVMFGEMLNPGVLHDAQVAAQESDVFMVVGSTA 194 Query: 181 HVYPAAGFVHEAKLHGAHTVELNLEPSQ-VGNEFAEKYYGPASQVVPEFVE 230 VYPAA A GA + LN+EP + A G A ++P + Sbjct: 195 VVYPAAELPQLAMSRGARLITLNMEPLPQLDAAAAVVLRGAAEVLLPRLLA 245 >UniRef50_Q1QTH0 Silent information regulator protein Sir2 n=3 Tax=Bacteria RepID=Q1QTH0_CHRSD Length = 242 Score = 207 bits (528), Expect = 2e-52, Method: Composition-based stats. Identities = 101/230 (43%), Positives = 137/230 (59%), Gaps = 5/230 (2%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 + P ++VLTGAGISAESG++TFR DGLWE HRV+DVATPE F RDPE V FY+ARR Sbjct: 5 QGPHLVVLTGAGISAESGLKTFRDGDGLWENHRVQDVATPEAFARDPETVLRFYDARRE- 63 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 Q + PNAAH ALA+L+ A G + ++TQNID+LHERAG+ +V+H+HGE+L R S + Sbjct: 64 -QTRQATPNAAHRALAELEQA-GFQVSVITQNIDDLHERAGSRDVLHLHGEILMSR-SSA 120 Query: 122 GQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGH 181 L + C + LRP VVWFGE + ++ AD+ + +GTS Sbjct: 121 DPNLRYPVGRKGIRLGDLCDKGSQLRPDVVWFGEPVPRYAQACEIVAEADLVLVVGTSLA 180 Query: 182 VYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEK 231 V PAA + +A + A + ++ + + ASQ VP VE Sbjct: 181 VMPAAMLLDQAPIE-APCLLVDPQAESLVPRGVRAISQLASQGVPPLVEH 229 >UniRef50_Q0CI01 Putative uncharacterized protein n=2 Tax=Leotiomyceta RepID=Q0CI01_ASPTN Length = 320 Score = 207 bits (528), Expect = 2e-52, Method: Composition-based stats. Identities = 92/303 (30%), Positives = 133/303 (43%), Gaps = 71/303 (23%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 RV+ L GAGISA SG+ TFR A GLW + D+ATPE F+ +P+LV FY+ RR Sbjct: 20 RSRRVIALLGAGISASSGLPTFRGAGGLWRTYEATDLATPEAFEANPDLVWQFYSYRRHM 79 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERA--GNTNVIHMHGELLKVRCS 119 + QPN AH ALA+L F+ +TQN+D L +RA + + +HG L V+C+ Sbjct: 80 --ALKAQPNRAHHALAELARR-NKDFITLTQNVDGLSQRAQHPSEQIHLLHGSLFTVKCT 136 Query: 120 Q--S-------------------------------------------------GQVLDWT 128 G+ +D + Sbjct: 137 SFYCNYSRHDDFTDPIVPALAIPRNLPEPKPSADDNTGEEASRSLYNALGIAEGEEIDIS 196 Query: 129 GDVTPED------KCHCCQFPA-PLRPHVVWFGEMPLG--MDEIYMALSM--ADIFIAIG 177 D P C + LRP VVWFGE +D + L D+ + IG Sbjct: 197 DDRVPLPGLSTDVLPKCPECKEGLLRPGVVWFGESLPTHTLDTVDSWLRSGPVDLILVIG 256 Query: 178 TSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVG----NEFAEKYYGPASQVVPEFVEKLL 233 TS VYPAAG+V +A+ GA +N++ + VG + G A +VPE ++ ++ Sbjct: 257 TSSRVYPAAGYVDKARARGARVAVVNMDRNDVGSSGLKAGDWFFKGDAGIIVPEILKGVI 316 Query: 234 KGL 236 + Sbjct: 317 GEI 319 >UniRef50_B8JAI9 Silent information regulator protein Sir2 n=5 Tax=Myxococcales RepID=B8JAI9_ANAD2 Length = 279 Score = 207 bits (526), Expect = 3e-52, Method: Composition-based stats. Identities = 89/256 (34%), Positives = 120/256 (46%), Gaps = 27/256 (10%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLW----EEHRVEDVATPEGFDRDPELVQAFYNARRR 60 +V+ LTGAGISAESGI TFR A+G W + +++AT E F+ P+ V +Y R Sbjct: 26 KVVALTGAGISAESGIPTFRGAEGYWVVGSRNYMPQEMATREMFEAAPDEVWRWYLYRFG 85 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRC-S 119 + + +PN H AL +L+ ALG+RF LVTQNID LH RAG+ V +HG+ VRC + Sbjct: 86 VCR--DARPNPGHEALVRLEAALGERFTLVTQNIDGLHRRAGSRRVFCIHGDAAYVRCAA 143 Query: 120 QSG-----------QVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPL----GMDEIY 164 + G + D + C LRPHV+WF E MD Sbjct: 144 ECGVGLLDLPAMAPRRKDDPFTERERSQLSCPACGGWLRPHVLWFDEYYDEANYRMDSAV 203 Query: 165 MALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFA-----EKYYG 219 A AD+ + +GTSG A GA V++N E + A G Sbjct: 204 RAAEAADLLLVVGTSGATNLPMQIGRIAFHRGAALVDVNPEENPFAELAARSERGFFARG 263 Query: 220 PASQVVPEFVEKLLKG 235 A +P V L G Sbjct: 264 SACARLPGIVAALGAG 279 >UniRef50_D2RCH9 Transcriptional regulator, Sir2 family n=7 Tax=Bifidobacteriaceae RepID=D2RCH9_GARVA Length = 257 Score = 207 bits (526), Expect = 4e-52, Method: Composition-based stats. Identities = 68/247 (27%), Positives = 104/247 (42%), Gaps = 19/247 (7%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHR-VEDVATPEGFDRDPELVQAFYNARRR 60 + ++VLTGAGIS +GI FR DG+W +H V + F E + ++ Sbjct: 9 KAHHIVVLTGAGISTSAGIPDFRGPDGVWTKHPEQMSVYDIDAFLSSKEERVYSWRWQKE 68 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELLKVRC 118 QP AH AL KL+ G L+ TQN D LHE+AG ++++HG + C Sbjct: 69 SPVW-NAQPGTAHKALVKLE-KAGMLDLIATQNFDALHEKAGNNPDIIVNLHGSIGTSHC 126 Query: 119 SQSGQVL---DWTGDVTPEDKCHCCQ---------FPAPLRPHVVWFGEMPLG--MDEIY 164 D D+ HC + ++ VV+FGE M+ Sbjct: 127 MSCHASYKTADIMADLDEHPDPHCRRTLPYRSNMPCNGLIKTDVVYFGEALPEGAMERSA 186 Query: 165 MALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQV 224 A+ AD IG++ V+PAA V A G +NL +Q ++ Sbjct: 187 QAIVKADELWVIGSTLEVFPAASLVPLAARAGVPITIMNLGSTQYDYLAERIIREDIAKA 246 Query: 225 VPEFVEK 231 +P+ V++ Sbjct: 247 LPKLVDE 253 >UniRef50_A2QWZ2 Function: human SIRT5 belongs to the Sir2-like proteins n=1 Tax=Aspergillus niger CBS 513.88 RepID=A2QWZ2_ASPNC Length = 258 Score = 207 bits (526), Expect = 4e-52, Method: Composition-based stats. Identities = 84/243 (34%), Positives = 124/243 (51%), Gaps = 14/243 (5%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 RV+ L GAGISA SG+ TFR A GLW + D+ATPE FD +P+LV FY+ RR Sbjct: 21 CRRVIALLGAGISASSGLPTFRGAGGLWRSYDATDLATPEAFDANPDLVWQFYSYRRHM- 79 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG 122 + QPN AH ALA+L F+ ++QN+D+ + ++ G Sbjct: 80 -ALKAQPNRAHYALAELARK-NKDFITLSQNVDDRTGEEASRSIASALGNNEDEADVSDE 137 Query: 123 QVLDWTGDVTPEDKCHCCQFPA-PLRPHVVWFGEMPLG--MDEIYMALS--MADIFIAIG 177 +V V E+ HC + LRP VVWFGE +D + L+ D+ + +G Sbjct: 138 RVP--LSAVPYEELPHCPECKDGLLRPGVVWFGESLPSHTIDYVDEWLNKGKVDLILVVG 195 Query: 178 TSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVG----NEFAEKYYGPASQVVPEFVEKLL 233 TS VYPAAG+V +A+ GA +N++ + VG + G A +VPE ++ ++ Sbjct: 196 TSSRVYPAAGYVDKARSKGARVAVVNMDRNDVGSSGLKPGDWFFEGDAGTIVPEILKGVI 255 Query: 234 KGL 236 + Sbjct: 256 GDI 258 >UniRef50_Q3A6W7 NAD-dependent protein deacetylases, SIR2 family n=2 Tax=Pelobacter RepID=Q3A6W7_PELCD Length = 278 Score = 207 bits (526), Expect = 4e-52, Method: Composition-based stats. Identities = 65/246 (26%), Positives = 101/246 (41%), Gaps = 24/246 (9%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLW--EEHRVEDVATPEGFDRDPELVQAFYNARR 59 V+ L+GAGIS +GI FR GL+ + E V + F R+P + FY R Sbjct: 31 RSRCVVTLSGAGISTAAGIPDFRGPQGLYVTRRYDPEKVFDIDWFHREP---RYFYEFTR 87 Query: 60 RQLQQPEI-QPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRC 118 + + +P H LA L+ A G L+TQNID LH+ AG+ VI +HG +C Sbjct: 88 DFVSTVKAIRPTFTHRFLAGLEKAGG-LAGLITQNIDMLHQLAGSRKVIDLHGSYRSAQC 146 Query: 119 SQSGQVLDWTGDVTP---------EDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSM 169 G+ + +C + L+P +V+FGEM + ++ Sbjct: 147 LFCGKSYEALSYTWWERAMSTSSKPPLAYCSACNSVLKPDIVFFGEMVHAFEAAEQLIAQ 206 Query: 170 ADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPS---QVGNEFAEKYYGPASQVVP 226 D+ + +G+S V PA+ + A TV +N + F G Sbjct: 207 CDLLLVLGSSLKVTPASLLPYH---TQATTVVVNRGAVMLPPAPHRF--FVDGDLDVYFR 261 Query: 227 EFVEKL 232 + L Sbjct: 262 AVAKHL 267 >UniRef50_A4QUX8 Putative uncharacterized protein n=1 Tax=Magnaporthe grisea RepID=A4QUX8_MAGGR Length = 460 Score = 206 bits (525), Expect = 4e-52, Method: Composition-based stats. Identities = 66/246 (26%), Positives = 96/246 (39%), Gaps = 21/246 (8%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAAD-GLWEEHR------VEDVATPEGFDRDPELVQAF 54 + R+ V+TGAGIS +GI FR+ GL+ E V F PE F Sbjct: 38 KVKRITVMTGAGISTAAGIPDFRSPGTGLYSNLERLKLPEPEAVFDISFFRDRPEP---F 94 Query: 55 YNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGN--TNVIHMHGE 112 Y + L + QP +H +A L G + TQNID L +AG VI HG Sbjct: 95 YVLAKE-LYPGKFQPTISHAFIALLSKK-GLLQMNFTQNIDCLERQAGVPGEKVIEAHGS 152 Query: 113 LLKVRCSQSGQVLDWTGDVTPEDK---CHCCQFPAPLRPHVVWFGEMPLG-MDEIYMALS 168 C + ++ + +K C ++P++V+FGE E ++ Sbjct: 153 FATQSCIECKELFPDDEMLLHVEKEIVPRCASCNGLVKPNIVFFGEPLPRTFSEKCHLVA 212 Query: 169 MADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQ--VGNEFAEKYYGPASQVVP 226 +D+ I IGTS VYP AG G+ + LN G V Sbjct: 213 ESDLAIIIGTSLTVYPFAGLPELVP-RGSPRLLLNKVRVGQIGTRSDDVVELGSCDAGVR 271 Query: 227 EFVEKL 232 + + L Sbjct: 272 KLADLL 277 >UniRef50_B3RLQ5 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens RepID=B3RLQ5_TRIAD Length = 386 Score = 206 bits (524), Expect = 5e-52, Method: Composition-based stats. Identities = 62/258 (24%), Positives = 104/258 (40%), Gaps = 27/258 (10%) Query: 3 KPRVLVLTGAGISAESGIRTFRAAD-GLWEEHR------VEDVATPEGFDRDPELVQAFY 55 +L+L GAGIS SGI FR+ G++ + D + F +P + FY Sbjct: 126 CKNILILAGAGISTSSGIPDFRSPKTGIYSILKNNNLSSPTDAFDIDYFRSNPAV---FY 182 Query: 56 NARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERA--GNTNVIHMHGEL 113 + L + +PN AH + L D G + TQNID L A ++ ++ HG Sbjct: 183 ELAKD-LYPGQYRPNYAHYFIKLLCDK-GLLGRMYTQNIDGLERLADIPSSKLVEAHGTF 240 Query: 114 LKVRCSQSGQVLD---WTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPL-GMDEIYM-ALS 168 C+ + + + + C + ++P +V+FGE ++Y ++ Sbjct: 241 SSATCTCCKKTFNGDFIKSAIMNKIIPKCDRCSGIIKPDIVFFGENLPKRFYKLYKKDIA 300 Query: 169 MADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEP----SQVGNEFAEKYY-GPASQ 223 D+ I +GTS V P A V + V +N E ++ F + Y G Sbjct: 301 GCDLVIVMGTSLQVEPFASLVDKIPQR-TPRVLINKEIVGPFTRKKRRFTDIIYTGDIVD 359 Query: 224 VVPEFVEKLLKGLKAGSI 241 + E + GL+ I Sbjct: 360 GLKELAKN--AGLRDEMI 375 >UniRef50_B2VWU1 NAD-dependent deacetylase sirtuin-5 n=3 Tax=Leotiomyceta RepID=B2VWU1_PYRTR Length = 320 Score = 206 bits (524), Expect = 6e-52, Method: Composition-based stats. Identities = 87/287 (30%), Positives = 130/287 (45%), Gaps = 55/287 (19%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 + R+L L GAG+SA SG+ TFR A G+W H +ATP+ F+RDP LV FY+ RR Sbjct: 25 KSTRILALLGAGLSASSGLPTFRGAGGMWRTHDATSLATPQAFERDPGLVWQFYSYRRHM 84 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERA--GNTNVIHMHGELLKVRCS 119 + +PN AH ALA+L + F+ ++QN+D L RA + +HG L V+CS Sbjct: 85 --ALKAKPNPAHYALAELARKR-EEFITLSQNVDGLSPRAQHPIDKLKLLHGSLFDVKCS 141 Query: 120 Q--SGQVLDWTG--------------------------------------DVTPEDKCHC 139 V ++ HC Sbjct: 142 DFFCKYVERNNYTDPIVPALAIPSDDSDPTTTSALAARELDISDINVAIPELDYSHLPHC 201 Query: 140 CQFPA-PLRPHVVWFGEMPLG-----MDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAK 193 LRP VVWFGE +D+ D+ + IGTS VYPAAG+V EA+ Sbjct: 202 PACKTGLLRPGVVWFGEALPKDVMKDVDDFIDDDRNVDLIMVIGTSAKVYPAAGYVDEAR 261 Query: 194 LHGAHTVELNLEPSQVG----NEFAEKYYGPASQVVPEFVEKLLKGL 236 + GA +N++P + + + G A+++VPE ++ ++ + Sbjct: 262 MKGARVAVINMDPEDIPAGGLYDKDWFFQGDAARIVPELLKSVIGEI 308 >UniRef50_D2Q7L2 SIR2 family protein n=13 Tax=Bifidobacterium RepID=D2Q7L2_9BIFI Length = 254 Score = 205 bits (523), Expect = 7e-52, Method: Composition-based stats. Identities = 70/246 (28%), Positives = 110/246 (44%), Gaps = 19/246 (7%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHR-VEDVATPEGFDRDPELVQAFYNARRRQ 61 ++ VLTGAGIS +GI FR DG+W +H +V + F + E + + ++ Sbjct: 2 SKKIAVLTGAGISTSAGIPDFRGPDGVWTKHPEQMNVYDIDAFLANEEDREYSWRWQKES 61 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTN--VIHMHGELLKVRCS 119 QP AH AL KL+ A G LL TQN D LHE+AGN++ ++++HG + C Sbjct: 62 PVW-NAQPGEAHKALVKLEQA-GMLTLLATQNFDALHEKAGNSDNVIVNLHGTIGTSHCM 119 Query: 120 QSGQVLD---WTGDVTPEDKCHCCQ---------FPAPLRPHVVWFGEMPLG--MDEIYM 165 + D ++ E HC + ++ VV+FGE M++ Y Sbjct: 120 KCHAKYDTADIMANLDNEPDPHCHRKLPYSGNMPCNGLIKTDVVYFGEALPDGAMEKSYR 179 Query: 166 ALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVV 225 + AD IG++ V PAA V A G +N+ +Q + + Sbjct: 180 LATQADELWVIGSTLEVMPAASIVPVAAQAGVPITIMNMGHTQYDRLADRLIRDDIAVAL 239 Query: 226 PEFVEK 231 P V++ Sbjct: 240 PRLVDE 245 >UniRef50_B6GXN1 Pc12g08000 protein n=1 Tax=Penicillium chrysogenum Wisconsin 54-1255 RepID=B6GXN1_PENCW Length = 267 Score = 205 bits (523), Expect = 9e-52, Method: Composition-based stats. Identities = 82/250 (32%), Positives = 118/250 (47%), Gaps = 22/250 (8%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 R++ L GAGISA SG+ TFR A GLW H +ATPE FD P LV FY+ RR Sbjct: 24 CKRIVALLGAGISASSGLPTFRGAGGLWRSHDATSLATPEAFDETPGLVWQFYSYRRHM- 82 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERA-------GNTNVIHMHGELLK 115 + PN AH ALA+L + FL ++QN+D L+ A + + + Sbjct: 83 -ALQADPNRAHYALAELARR-NEDFLTLSQNVDGLNPSATDKTGEQASKAIGEALDDTST 140 Query: 116 VRCSQSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSM------ 169 T +C C+ LRP VVWFGE ++ A+ Sbjct: 141 EVDISDASNPIATVAREDLPQCPKCEDG-LLRPGVVWFGEPLP--EKTIRAVDKWIAAGP 197 Query: 170 ADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEP--SQVG-NEFAEKYYGPASQVVP 226 D+ + IGTS V+PAAG+VHEA+ GA N++P + + + G A +VP Sbjct: 198 VDLCLVIGTSAKVFPAAGYVHEARSQGARVAVCNMDPNDTPGELHYGDWFFQGDAGVIVP 257 Query: 227 EFVEKLLKGL 236 E ++ ++ + Sbjct: 258 EILKSVIGDI 267 >UniRef50_A0NQ49 Silent information regulator protein Sir2 n=2 Tax=Labrenzia RepID=A0NQ49_9RHOB Length = 260 Score = 205 bits (522), Expect = 1e-51, Method: Composition-based stats. Identities = 67/240 (27%), Positives = 103/240 (42%), Gaps = 19/240 (7%) Query: 4 PRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL- 62 +++ LTGAGIS ESGI FR+ G+W + + + F D + ++ R Sbjct: 23 RQIVALTGAGISTESGIPDFRSPGGIWSKRQPVQ---YQDFVDDEDSRLEDWDRRLEDWD 79 Query: 63 -------QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTN--VIHMHGEL 113 + +PNAAH AL L G L+TQN+D LH+RAG + ++ +HG Sbjct: 80 RRSEMMDYFCKAEPNAAHFALTTLA-RSGKLVCLITQNVDGLHQRAGFPDDLLVEIHGNS 138 Query: 114 LKVRCSQSGQVLDWTGDVTPEDK---CHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALS 168 C G + D C Q L+ V+ FG+ + A S Sbjct: 139 TFASCLSCGARAELEAQKPAVDAGESPRCSQCDGLLKAAVISFGQQMPERELQRAAEAAS 198 Query: 169 MADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEF 228 D+F+ +G+S V+PAA A GA V LN + + + + + P +Q F Sbjct: 199 ACDLFLVLGSSLVVHPAAQLPAVAVQSGAELVILNGQETPLDSYASTIVRTPLAQTFAGF 258 >UniRef50_C4R311 NAD(+)-dependent histone deacetylase n=3 Tax=Saccharomycetales RepID=C4R311_PICPG Length = 325 Score = 205 bits (521), Expect = 2e-51, Method: Composition-based stats. Identities = 80/302 (26%), Positives = 129/302 (42%), Gaps = 69/302 (22%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 + +L L GAG+SA SG+ TFR + GLW+ + D+ATP+ F+ DP LV FY+ RR Sbjct: 17 KCRTILALCGAGLSASSGLPTFRGSGGLWKNYSSMDLATPDAFNVDPGLVWQFYSYRR-- 74 Query: 62 LQQPEIQPNAAHLALAKLQD---ALGDRFLLVTQNIDNLHERAGN--TNVIHMHGELLKV 116 + + +PN H AL++L + G +FL +TQN+D L RA + ++ +HG L + Sbjct: 75 YKAIQAKPNNGHYALSQLSKVAASKGKKFLTLTQNVDGLSRRAHHDPEQLLELHGSLFTL 134 Query: 117 RCS--QSGQVLDWTGDVTPEDKCHCCQ--------------------------------- 141 +C+ + + C+ Sbjct: 135 KCTSFDCTYTENNNFKHPLTPQLQGCEEEWINPRKRQRRTENENENENENEDGKDAVIST 194 Query: 142 -------------------FPAP----LRPHVVWFGEMPLG--MDEIYM--ALSMADIFI 174 P LRP VVWFGE +D+ D+ + Sbjct: 195 TGSPEFTPVKEIPRSGLPTCPQCKTGLLRPGVVWFGESLPFKVLDQADQFIMSQKVDLIL 254 Query: 175 AIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLK 234 IGTS V+PAAG+V+ KL G N + + K+ G A++++P+ ++ L+ Sbjct: 255 VIGTSQSVWPAAGYVNRVKLQGGKVAIFNTDEEDLEGCDGWKFLGDAAELLPQALKPLIG 314 Query: 235 GL 236 + Sbjct: 315 DI 316 >UniRef50_C3YDA2 Putative uncharacterized protein n=1 Tax=Branchiostoma floridae RepID=C3YDA2_BRAFL Length = 323 Score = 204 bits (520), Expect = 2e-51, Method: Composition-based stats. Identities = 66/264 (25%), Positives = 105/264 (39%), Gaps = 41/264 (15%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATP---EGFDRDPELVQAFYNARR 59 R+LV+TGAG+S ESG+ +R+ + V P + F +D + Q N R Sbjct: 61 SKRLLVITGAGLSTESGLPDYRSVKSPPRAGKDRPVIGPVMYQDFVKDTHVRQG--NWAR 118 Query: 60 RQLQQPEI---QPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKV 116 + P +PN +H AL + + G LVTQN+D+LH +AG+ + +HG + Sbjct: 119 NYVGWPGFSSHRPNVSHRALVQWE-RQGKLHWLVTQNVDDLHRKAGSERMTELHGSAFRA 177 Query: 117 RCSQSGQVLDW------------------------------TGDVTPEDKCHCCQFPAPL 146 C V+ + HC + PL Sbjct: 178 ACLSCKHVVPRSGLQQVISNMNPHWEAVPFEIRPDADVALTPEQIEGFRAPHCGKCGGPL 237 Query: 147 RPHVVWFGEMPLG--MDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNL 204 +P +V+FGE + ++ L +D + G+S VY A FV A LN+ Sbjct: 238 KPDMVYFGECVPKDTVQLVFEKLEESDSILVAGSSLQVYSAYRFVSAAHKQNKPVAILNI 297 Query: 205 EPSQVGNEFAEKYYGPASQVVPEF 228 P++ N A K V+ + Sbjct: 298 GPTRADNLAALKINSRCGDVLTKL 321 >UniRef50_C4WX51 ACYPI009170 protein n=1 Tax=Acyrthosiphon pisum RepID=C4WX51_ACYPI Length = 333 Score = 204 bits (519), Expect = 2e-51, Method: Composition-based stats. Identities = 64/265 (24%), Positives = 107/265 (40%), Gaps = 42/265 (15%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 E ++LVLTGAGIS ESGI +R+AD GL+ + V + F ++PE+ ++ R Sbjct: 71 EHKKILVLTGAGISTESGIPDYRSADVGLYARSKNRPVI-YQQFIKNPEVRIRYW--ARN 127 Query: 61 QLQQPEIQ---PNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVR 117 + P PN AH L L+D ++TQN+DNLH +AG+ NV+ +HG V Sbjct: 128 YVGWPRFSSMSPNYAHKFLKNLEDK-NKIVHIITQNVDNLHTKAGSKNVLELHGTAYVVH 186 Query: 118 CSQSGQVLDWT-------------------------------GDVTPEDKCHCCQF-PAP 145 C + +D ++ C + Sbjct: 187 CLKCDYTIDRHKFQDVLSSLNPQVSIKELYSVRPDGDVELPPEEIGGFKVPECPKCQGNL 246 Query: 146 LRPHVVWFGEMPL--GMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELN 203 L P +V+FG+ + + + D + +G+ VY V K +N Sbjct: 247 LIPRLVFFGDNLPKKRVQRVNDFVEECDSLLVMGSFLFVYSGYRIVLGTKFVNKPVAVVN 306 Query: 204 LEPSQVGNEFAEKYYGPASQVVPEF 228 + P++ + K +++P Sbjct: 307 IGPTRGDDWVDFKIEARFGEILPLL 331 >UniRef50_Q6C8C7 YALI0D20724p n=1 Tax=Yarrowia lipolytica RepID=Q6C8C7_YARLI Length = 303 Score = 204 bits (519), Expect = 2e-51, Method: Composition-based stats. Identities = 82/286 (28%), Positives = 120/286 (41%), Gaps = 54/286 (18%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 + ++L L GAG+S SG+ TFR G+W + ++ATPE F DP V FY RR Sbjct: 14 LSSRKILALVGAGLSQSSGLPTFRGEGGIWRNYDAAELATPEAFHNDPSTVWQFYAHRRH 73 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTN--VIHMHGELLKVRC 118 + +PN H ALA+L L RFL +TQN+D L RA + ++ +HG+L ++C Sbjct: 74 M--SLKAKPNPGHYALAELARRLRGRFLTLTQNVDGLSSRAEHPQEALLKLHGDLFALKC 131 Query: 119 SQ--SGQVLDWT----------------------GDVTPEDKCHCCQFPA-PLRPHVVWF 153 + + + ED C LRP VVWF Sbjct: 132 TSFFCSYTTEDNFADPLTPALSITDNYNSAQLQRHRIPVEDLPTCPHCKEGLLRPGVVWF 191 Query: 154 GEMPLGM-----DEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEP-- 206 GE DE D+ I +GTSG V+PAAG+V L G N+E Sbjct: 192 GESLPFKVMNTADEFLED-EDVDLIIVVGTSGSVWPAAGYVERVALSGGKVAIFNMEIDH 250 Query: 207 ----------SQVGNEFA-------EKYYGPASQVVPEFVEKLLKG 235 + + + G AS+ +P+ +E ++ Sbjct: 251 YQYGESEAETTDSEDSSNEDAVIEGWAFKGNASEWLPKALEPVIGR 296 >UniRef50_UPI000186DFC4 NAD-dependent deacetylase sirtuin-4, putative n=1 Tax=Pediculus humanus corporis RepID=UPI000186DFC4 Length = 316 Score = 203 bits (518), Expect = 3e-51, Method: Composition-based stats. Identities = 56/267 (20%), Positives = 103/267 (38%), Gaps = 40/267 (14%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 + V VLTGAG+S ESGI +R+ GL++ + F ++ ++ R Sbjct: 49 KNSSVAVLTGAGVSTESGIPDYRSETGLYKRTK-YRPIDYSTFLKNKAARIRYW--ARNY 105 Query: 62 LQQPEI---QPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRC 118 + PE +PN H AL +L +A G ++TQN+D LH +A N+I +HG V+C Sbjct: 106 VGWPEFSSKEPNGTHFAL-QLYEAAGKVSGIITQNVDGLHHKASGHNIIELHGNAYWVKC 164 Query: 119 SQSGQVLDWTG-------------------------------DVTPEDKCHCCQFPAPLR 147 ++ C + L+ Sbjct: 165 LSCKNLIFRHDFQKILDALNPSVQETGKIFVRPDGDVEIDESVYENFKIPDCEKCGGILK 224 Query: 148 PHVVWFGEMPLG--MDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLE 205 P +V+FG+ + + + +D + +GT+ + V +A + +NL Sbjct: 225 PTIVFFGDNVPKVTVKKAENLIESSDALLVMGTTLSTLSSLRIVTQAFDLCKYICIVNLG 284 Query: 206 PSQVGNEFAEKYYGPASQVVPEFVEKL 232 ++ S+++P + +L Sbjct: 285 ETRGDKMADIVINAKCSEILPNYNREL 311 >UniRef50_Q3V7G9 NAD-dependent deacetylase (Regulatory protein sirtuin family) n=11 Tax=Acinetobacter RepID=Q3V7G9_ACIAD Length = 233 Score = 203 bits (518), Expect = 3e-51, Method: Composition-based stats. Identities = 91/243 (37%), Positives = 128/243 (52%), Gaps = 24/243 (9%) Query: 4 PRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQ 63 +++V +GAG+SAESGI TFR DGLWE +R+E+VATPE + ++P LVQ FYN RR+ + Sbjct: 2 KKLVVFSGAGMSAESGIHTFRDHDGLWENYRIEEVATPEAWQQNPSLVQHFYNERRKNIL 61 Query: 64 QPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQ 123 QPN AH +A+L+ + ++TQNID+LHERAG+T+V+H+HG + + S Sbjct: 62 A--AQPNLAHQIIAQLE--SCYQVQVITQNIDDLHERAGSTHVLHLHGNIRLAKSSGPNA 117 Query: 124 VL---DWTGDVTPEDKCH-CCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTS 179 + D D C PLRPHVVWFGE D+ L AD+FI IG++ Sbjct: 118 QFTQTFYPIDGWQLDLNQDKCNEGYPLRPHVVWFGEAVPAYDDAIAMLKDADVFIVIGST 177 Query: 180 GHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEK--------YYGPASQVVPEFVEK 231 VYP AG +HE H + A++ + + K Sbjct: 178 LSVYPVAGLIHEIPNHCEAYYI--------DPQADYFRVPHQYTLLKMTATEGMKQLYLK 229 Query: 232 LLK 234 L Sbjct: 230 LKN 232 >UniRef50_C4XZ95 Putative uncharacterized protein n=1 Tax=Clavispora lusitaniae ATCC 42720 RepID=C4XZ95_CLAL4 Length = 522 Score = 203 bits (516), Expect = 5e-51, Method: Composition-based stats. Identities = 65/265 (24%), Positives = 99/265 (37%), Gaps = 38/265 (14%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEH------RVEDVATPEGFDRDPELVQAFYN 56 ++LV+TGAGIS GI FR++ G + ++V + F DP + FY+ Sbjct: 204 AKKILVITGAGISTSLGIPDFRSSKGFYSRLSNLGLSDPQEVFDLDIFRTDPSI---FYS 260 Query: 57 ARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGN--TNVIHMHGELL 114 L + H + LQD TQNIDNL AG +I HG Sbjct: 261 IAYMILPPDNV-YAPLHRFIKLLQDK-NKLLRNYTQNIDNLEANAGISQDKMIQCHGSFA 318 Query: 115 KVRCSQSGQVLD---WTGDVTPEDKCHCCQF------------------PAPLRPHVVWF 153 C G + + ++ +C ++P++ +F Sbjct: 319 FSTCVTCGYQVPGETLYPLMRKKEIPYCPMCAKKRKKLMDNDDTYIEESYGVMKPNITFF 378 Query: 154 GEMPLGM--DEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGN 211 GE + D I L+ D+ I+IGTS V P A V + + + +N +P Q N Sbjct: 379 GEALPRVFHDNINRDLADCDLVISIGTSLKVAPVADIVDKVRPE-VPQILINKDPIQHCN 437 Query: 212 EFAEKYYGPASQVVPEFVEKLLKGL 236 F G VV +L Sbjct: 438 -FDVSLLGYCDDVVSYLCHRLGSEW 461 >UniRef50_D2A3P1 Putative uncharacterized protein GLEAN_14968 n=1 Tax=Tribolium castaneum RepID=D2A3P1_TRICA Length = 612 Score = 203 bits (516), Expect = 6e-51, Method: Composition-based stats. Identities = 63/270 (23%), Positives = 115/270 (42%), Gaps = 40/270 (14%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 + ++LVLTGAGIS ESGI +R+ D GL+ V + F + ++ Q ++ R Sbjct: 42 DYDKILVLTGAGISTESGIPDYRSEDVGLYARTNHRPV-QYQEFLKSEKVRQRYW--ARN 98 Query: 61 QLQQPEI---QPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVR 117 + P+ QPN H + + +++G +VTQN+D+LH +AG+ NVI +HG +V Sbjct: 99 YIGWPKFSQTQPNITHY-IVQFLESVGKVGCVVTQNVDSLHFKAGSGNVIELHGTAFRVI 157 Query: 118 CSQSGQVLDWT------------------------------GDVTPEDKCHCCQFPAPLR 147 C + G+ D V C L+ Sbjct: 158 CLKCGKNYDRHKVQEKLIGLNPDLRETSQMIRPDGDVEISQEKVENFKPPFCDHCQGVLK 217 Query: 148 PHVVWFGEMPL--GMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLE 205 P + +FG+ +D++ ++ +D + +G+S V+ + +A +N+ Sbjct: 218 PDITFFGDNVPKERVDKVRQNVTQSDAILVLGSSLSVFSGYRIILQAVEEKKDVAIVNIG 277 Query: 206 PSQVGNEFAEKYYGPASQVVPEFVEKLLKG 235 P++ K +VP + ++K Sbjct: 278 PTRADKHAKLKISARYGLIVPNKDKAVIKR 307 >UniRef50_Q5R1T8 NAD-dependent deacetylase sirtuin 2 homolog n=2 Tax=Coelomata RepID=Q5R1T8_BOMMO Length = 387 Score = 202 bits (515), Expect = 6e-51, Method: Composition-based stats. Identities = 51/264 (19%), Positives = 95/264 (35%), Gaps = 39/264 (14%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAA-DGLWEEHRVEDVATPEG------FDRDPELVQAF 54 +++ L+GAGIS +GI FR+ GL+ + ++ P+ F ++P+ Sbjct: 86 RCKKIITLSGAGISTSAGIPDFRSPETGLYHNLQKYELPQPQAIFEINFFRQNPKPFFT- 144 Query: 55 YNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGE 112 ++L +P +H + L + G TQNID L AG ++ HG Sbjct: 145 ---LAKELFPGSFKPTISHYFIRLLHEK-GLLLRHYTQNIDTLERGAGIPEEKLVEAHGT 200 Query: 113 LLKVRCSQSGQVLDW---TGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEI--YMAL 167 C + + + C + P ++P +V+FGE ++ Sbjct: 201 FYTSHCLDCRKEYPLEFVKERIFADQIPICTECPGVVKPDIVFFGESLPERFQMCLEEDF 260 Query: 168 SMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQV------------------ 209 D+ I +G+S V P A + + +N E + V Sbjct: 261 KQCDMLIIMGSSLEVQPFASLIDMVPDSC-PRLLINREKAGVRPPILRIRGLMCGGLQLD 319 Query: 210 -GNEFAEKYYGPASQVVPEFVEKL 232 G+ G + + ++L Sbjct: 320 EGSYRDVARLGDCDEGCQDLADRL 343 >UniRef50_A8PZF9 NAD-dependent deacetylase SIRT1, putative n=1 Tax=Brugia malayi RepID=A8PZF9_BRUMA Length = 584 Score = 202 bits (515), Expect = 8e-51, Method: Composition-based stats. Identities = 56/244 (22%), Positives = 93/244 (38%), Gaps = 23/244 (9%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEH--------RVEDVATPEGFDRDPELVQA 53 R+LVLTGAG+S GI FR+ +G++ + F ++P+ Sbjct: 129 RCSRILVLTGAGVSVSCGIPDFRSRNGVYARLHVEYPDLPDPTAMFDINYFSKNPKPFFE 188 Query: 54 FYNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGEL 113 F R+L + + H + L+D+ G TQNID L + AG ++ HG Sbjct: 189 F----ARELFPGRYEASMCHYFIKALEDS-GKLLRNYTQNIDTLEQVAGIKRIVQCHGSF 243 Query: 114 LKVRCSQSGQVLD---WTGDVTPEDKCHCCQFPAP---LRPHVVWFGEMPLG--MDEIYM 165 C G +D D+ C P ++P +V+FGE +++ Sbjct: 244 ATATCRNCGLKVDSEAIREDIDSGRVAMCRVCSHPEGVMKPDIVFFGEDLSDDFHEKMAE 303 Query: 166 ALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVV 225 M D+ + IG+S V P A + + +N E + G +V Sbjct: 304 DREMVDLVVVIGSSLKVQPVALLPYNINPE-VPQILINRESLPH-YATDIELLGNCDDIV 361 Query: 226 PEFV 229 + Sbjct: 362 AQLA 365 >UniRef50_B6JXE7 Sir2 family histone deacetylase Hst2 n=1 Tax=Schizosaccharomyces japonicus yFS275 RepID=B6JXE7_SCHJY Length = 374 Score = 202 bits (514), Expect = 8e-51, Method: Composition-based stats. Identities = 58/244 (23%), Positives = 92/244 (37%), Gaps = 19/244 (7%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAAD----GLWEEHRVEDVATPEGFDRDPELVQAFYNA 57 + + V+ GAGIS +GI FR D L+ E + E F +P+ F+ Sbjct: 23 KYKNICVMVGAGISTAAGIPDFRRHDLLKHFLFNLPYAEAIFDLEYFRENPKP---FFEL 79 Query: 58 RRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELLK 115 + P H L L + G TQNID L AG ++ HG Sbjct: 80 AYELM-PGRYMPTPTHYFLR-LMNEKGLMLRCFTQNIDTLERIAGVPEDKIVEAHGSFQY 137 Query: 116 VRCSQSGQVLDWTGD---VTPEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMA 170 RC + ++ D + +D C + ++P +V++GE D +Y + Sbjct: 138 NRCIECKEMADSGYVRHCIETKDVPLCEKCKGYVKPTIVFYGEGLPSRFFDCMYEDMEKC 197 Query: 171 DIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQ--VGNEFAEKYYGPASQVVPEF 228 D+ + IGTS V+P A A + +N E E G +V + Sbjct: 198 DLALVIGTSLLVHPFADLPEIATENCQRL-LINREVVGDFSERESDLMVLGDCDALVRQL 256 Query: 229 VEKL 232 + L Sbjct: 257 CKYL 260 >UniRef50_B3WAV7 NAD-dependent deacetylase (Regulatory protein SIR2 homolog) n=18 Tax=Lactobacillales RepID=B3WAV7_LACCB Length = 230 Score = 202 bits (514), Expect = 1e-50, Method: Composition-based stats. Identities = 64/231 (27%), Positives = 101/231 (43%), Gaps = 14/231 (6%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLW-EEHRVEDVATPEGFDRDPELVQAFYNARRR 60 + V +TGAG+S SGI +R+ GL+ ++ E + + E F Sbjct: 10 QAKHVTFMTGAGVSTASGIPDYRSKGGLYADQVDPEYALSIDNLQAHHEDFHKF---VVN 66 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 + P +PN H +A + + G +VTQN+D L +AG +V+ HG L ++ C Sbjct: 67 NMYFPAAKPNVIHEKMATITNQKG---TIVTQNVDGLDRKAGAEHVVEFHGNLYRIYCQT 123 Query: 121 SGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGE--MPLGMDEIYMALSMADIFIAIGT 178 + D+ + + LRP +V +GE P + A+S AD+ I +GT Sbjct: 124 CHKHFDYETYLKSDVHAAD---GGILRPDIVLYGEPINPDTVSAAIEAISTADLLIVVGT 180 Query: 179 SGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFV 229 S VYP AG + A+ A V +N E + G A V + V Sbjct: 181 SFVVYPFAGLIGYAQPE-ATIVAVNREKIALPEGAHMV-QGDAVDVFAKLV 229 >UniRef50_Q1YSP9 NAD-dependent deacetylase n=1 Tax=gamma proteobacterium HTCC2207 RepID=Q1YSP9_9GAMM Length = 270 Score = 202 bits (513), Expect = 1e-50, Method: Composition-based stats. Identities = 68/266 (25%), Positives = 103/266 (38%), Gaps = 42/266 (15%) Query: 1 MEKP-RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARR 59 + R LVLTGAG+SAESG+ T+R G W+ T + F + + Q F+ R Sbjct: 8 LNSKARWLVLTGAGVSAESGVPTYRNQRGEWQRKPPV---THQEFTGNHQARQRFW--AR 62 Query: 60 RQLQQ---PEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKV 116 + +PN AH ALA L+ G LVTQN+D LH+RAG+ VI +HG + V Sbjct: 63 NLVGWRFMSSARPNGAHSALASLE-KAGAVSCLVTQNVDGLHQRAGSQKVIDLHGRVDSV 121 Query: 117 RCSQSGQVLDWTG------------------------------DVTPEDKCHCCQFPAPL 146 C L D + C L Sbjct: 122 SCLSCKLRLPRAPLQTWLEANNPDFAKLAGAIAPDGDADVDNLDHSSMQVPDCENCGGVL 181 Query: 147 RPHVVWFGEMPL--GMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNL 204 +P V+FG+ + + + AD + +G+S + F A G V +N Sbjct: 182 KPDAVFFGDSVPAQRVADAEQQMKDADGLVVVGSSLVAFSGYRFCLWASKQGKPIVIIND 241 Query: 205 EPSQVGNEFAEKYYGPASQVVPEFVE 230 ++ K G V+ +++ Sbjct: 242 GKTRGDELATAKVAGLCGDVLQGWLQ 267 >UniRef50_Q9NTG7 NAD-dependent deacetylase sirtuin-3, mitochondrial n=38 Tax=Metazoa RepID=SIRT3_HUMAN Length = 399 Score = 202 bits (513), Expect = 1e-50, Method: Composition-based stats. Identities = 66/244 (27%), Positives = 94/244 (38%), Gaps = 17/244 (6%) Query: 3 KPRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEGFDRDPELVQ---AFYNAR 58 RV+V+ GAGIS SGI FR+ GL+ + D+ PE P F+ Sbjct: 137 CQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIFELPFFFHNPKPFFTLA 196 Query: 59 RRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGN--TNVIHMHGELLKV 116 + L +PN H L L D G L TQNID L +G + ++ HG Sbjct: 197 KE-LYPGNYKPNVTHYFLRLLHDK-GLLLRLYTQNIDGLERVSGIPASKLVEAHGTFASA 254 Query: 117 RCSQSGQVL---DWTGDVTPEDKCHCCQFPAPLRPHVVWFGE-MPLGMDEIYMALSMADI 172 C+ + D DV + C ++P +V+FGE +P + MAD+ Sbjct: 255 TCTVCQRPFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADL 314 Query: 173 FIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQ----VGNEFAEKYYGPASQVVPEF 228 + +GTS V P A EA + +N + G V Sbjct: 315 LLILGTSLEVEPFASL-TEAVRSSVPRLLINRDLVGPLAWHPRSRDVAQLGDVVHGVESL 373 Query: 229 VEKL 232 VE L Sbjct: 374 VELL 377 >UniRef50_B0D7T5 Predicted protein n=3 Tax=Agaricales RepID=B0D7T5_LACBS Length = 332 Score = 201 bits (512), Expect = 1e-50, Method: Composition-based stats. Identities = 81/268 (30%), Positives = 116/268 (43%), Gaps = 47/268 (17%) Query: 3 KPRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 +L+L+GAG+SA SGI T+R+AD LW ATP+ F +DP V +Y+ RR++ Sbjct: 54 SKNILILSGAGLSAASGIPTYRSADESLWNNFDPTAYATPQAFAKDPSGVWRWYHNRRKE 113 Query: 62 LQQPEIQPNAAHLALAKLQ--DALGDRFLL-------VTQNIDNLHERAGN-------TN 105 + +PN AH ALA L AL +TQN+D+L R Sbjct: 114 YL--KAKPNNAHRALATLALPSALSRIAPCSMSQPLHITQNVDSLSLRLLESLSPEAAEG 171 Query: 106 VIHMHGELLKVRCSQSGQVL-----------------DWTGDVTPEDKCHCC-------- 140 +I MHG + +C+ +V+ + DV C Sbjct: 172 LIEMHGSIFVTKCTSCQKVMRSYAPSLASALDGDEDSNAKRDVPLCQLPKCGGDSWAGSN 231 Query: 141 ---QFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGA 197 LRP VVWFGEMP M E+ +S D+ + +GTS V PA+ F + K +G Sbjct: 232 RYGNCGGLLRPEVVWFGEMPPLMGEVSRKMSQCDLLLVVGTSSTVLPASSFATQVKANGG 291 Query: 198 HTVELNLEPSQVGNEFAEKYYGPASQVV 225 NL S +E + GP + Sbjct: 292 KVAVFNLNRSTGDDEADFLFLGPCETTL 319 >UniRef50_B3RYT4 Putative uncharacterized protein (Fragment) n=1 Tax=Trichoplax adhaerens RepID=B3RYT4_TRIAD Length = 382 Score = 201 bits (512), Expect = 1e-50, Method: Composition-based stats. Identities = 61/266 (22%), Positives = 94/266 (35%), Gaps = 41/266 (15%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPE------GFDRDPELVQAF 54 + ++V+ GAGIS +GI FR GL++ + D+ PE F +P F Sbjct: 45 KCKNIIVMAGAGISTSAGIPDFRTPGTGLYDNLQKYDLPDPESIFRLSYFRENP---SPF 101 Query: 55 YNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERA--GNTNVIHMHGE 112 Y+ + L +P +H + L D G TQNID L A +I HG Sbjct: 102 YSLAKE-LYPGRYKPTLSHYFIKLLHDK-GLLLRHFTQNIDTLEHLANVPKEKLIEAHGS 159 Query: 113 LLKVRCS--QSGQVL--DWTGDVTPEDK-CHCCQFPAPLRPHVVWFGEMPL--GMDEIYM 165 C + DW + +D C +P++P +V+FGE + Sbjct: 160 FSAAHCINHDCQKEYSSDWVKERVLQDIIPLCSNCNSPVKPDIVFFGESLPTKFFVATHE 219 Query: 166 ALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEP--SQ--------------- 208 D+ I +GTS V P A + + +NLE ++ Sbjct: 220 DFPQCDLLIIMGTSLKVQPFASLIERVPDA-TPRLLINLEKCGTRPKLFGALGINEGLSF 278 Query: 209 --VGNEFAEKYYGPASQVVPEFVEKL 232 N + G E L Sbjct: 279 DCESNYRDVFWQGTCDDGCFTLAEAL 304 >UniRef50_D2S8Y6 Silent information regulator protein Sir2 n=1 Tax=Geodermatophilus obscurus DSM 43160 RepID=D2S8Y6_9ACTO Length = 297 Score = 201 bits (512), Expect = 1e-50, Method: Composition-based stats. Identities = 72/264 (27%), Positives = 109/264 (41%), Gaps = 42/264 (15%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQ 64 +VL+GAG+S +SGI +R A G H T + F RDP ++ R + Sbjct: 38 NTVVLSGAGLSTDSGIPDYRGATGSLRRHTPM---TYQTFLRDPRGRHRYW--ARSFVGW 92 Query: 65 P---EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 P E +PNA H A+A LQ A G ++TQN+D LH+ AG +V+ +HG L + C Sbjct: 93 PQIREARPNAGHAAVADLQRA-GLVGGVITQNVDGLHQAAGARDVLELHGGLDRTVCLAC 151 Query: 122 GQVLDWTGDVTPED------------------------------KCHCCQFPA-PLRPHV 150 G V D C PL+P V Sbjct: 152 GDVADRGQLHERLRAVNPHFGPHVDEVNPDGDAELPDELLDGFVMVDCAACGRGPLKPDV 211 Query: 151 VWFGEMPLG--MDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQ 208 V+FGE +D + + A + +G+S V FV A+ G +NL P++ Sbjct: 212 VFFGETVPRDRVDTCFAMVEQAGSLLVLGSSLTVMSGYRFVLRAEKLGIPVGLVNLGPTR 271 Query: 209 VGNEFAEKYYGPASQVVPEFVEKL 232 + + P V+P+ V ++ Sbjct: 272 GDAKVDVRVDAPLGTVLPDLVRRV 295 >UniRef50_Q9I7I7 Sirt2 n=8 Tax=Drosophila RepID=Q9I7I7_DROME Length = 355 Score = 201 bits (512), Expect = 1e-50, Method: Composition-based stats. Identities = 54/262 (20%), Positives = 88/262 (33%), Gaps = 39/262 (14%) Query: 4 PRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATP------EGFDRDPELVQAFYN 56 +++ + GAGIS +GI FR+ GL+ + ++ P + F+++P Sbjct: 48 RKIVTMVGAGISTSAGIPDFRSPGSGLYSNLKKYELPHPTAIFDLDYFEKNPAPFF---- 103 Query: 57 ARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELL 114 A ++L P AH + L D G TQNID L G +I HG Sbjct: 104 ALAKELYPGSFIPTPAHYFIRLLNDK-GLLQRHYTQNIDTLDRLTGLPEDKIIEAHGSFH 162 Query: 115 KVRCSQSGQVLDWTG---DVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEI--YMALSM 169 C + + D ++ + C + ++P +V+FGE Sbjct: 163 TNHCIKCRKEYDMDWMKAEIFADRLPKCQKCQGVVKPDIVFFGENLPKRFYSSPEEDFQD 222 Query: 170 ADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQV-------------------G 210 D+ I +GTS V P A V +N + Sbjct: 223 CDLLIIMGTSLEVQPFASLVWRPGPRCIRL-LINRDAVGQASCVLFMDPNTRSLLFDKPN 281 Query: 211 NEFAEKYYGPASQVVPEFVEKL 232 N + G V + L Sbjct: 282 NTRDVAFLGDCDAGVMALAKAL 303 >UniRef50_B9GC62 Putative uncharacterized protein n=1 Tax=Oryza sativa Japonica Group RepID=B9GC62_ORYSJ Length = 446 Score = 201 bits (512), Expect = 1e-50, Method: Composition-based stats. Identities = 60/278 (21%), Positives = 102/278 (36%), Gaps = 53/278 (19%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 + +++VLTGAG+S ESGI +R+ +G + T + F R + ++ Sbjct: 110 QSKKLMVLTGAGMSTESGIPDYRSPNGAYSS--GFKPLTHQEFVRSIRARRRYWARSYAG 167 Query: 62 L-QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 + QPN+AH ALA L+ +G +VTQN+D LH RAG+ V +HG + +V C Sbjct: 168 WRRFRRAQPNSAHYALASLE-RIGRVHSMVTQNVDRLHHRAGSKPV-ELHGSVYEVACLD 225 Query: 121 SGQVLDWTGDVTP----------------------------------------------E 134 G +D Sbjct: 226 CGTSIDRESFQEQVKDLNPKWALAIDSLEVGQPGSDKSFGMQQRPDGDIEIDEKFWEQDF 285 Query: 135 DKCHCCQFPAPLRPHVVWFGEMPL--GMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEA 192 D C Q L+P VV FG+ + A D + +G++ A A Sbjct: 286 DIPSCNQCGGVLKPDVVMFGDNVPEERAESTKEAARNCDALLVVGSALMTMSAFRLARLA 345 Query: 193 KLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVE 230 A + + ++ + + K +++P ++ Sbjct: 346 HEANAPIAAITIGETRADSILSLKINARCGEILPRILQ 383 >UniRef50_Q9USN7 NAD-dependent deacetylase hst2 n=1 Tax=Schizosaccharomyces pombe RepID=HST2_SCHPO Length = 332 Score = 201 bits (511), Expect = 2e-50, Method: Composition-based stats. Identities = 53/247 (21%), Positives = 94/247 (38%), Gaps = 22/247 (8%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAA-DGLWEEHRVEDVATPEG------FDRDPELVQAF 54 + ++ V+ GAGIS +GI FR+ G++ + ++ E F ++P + F Sbjct: 26 KVKKICVMVGAGISTAAGIPDFRSPETGIYNNLQRFNLPYAEAVFDLSYFRKNP---RPF 82 Query: 55 YNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTN--VIHMHGE 112 Y + + +P H + L D TQNID L AG + +I HG Sbjct: 83 YELAHELM-PEKYRPTYTHYFIRLLHDKR-LLQKCYTQNIDTLERLAGVPDKALIEAHGS 140 Query: 113 LLKVRCSQSGQVLDWTGD---VTPEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMAL 167 RC + ++ + + + C ++P +V++GE + + Sbjct: 141 FQYSRCIECYEMAETEYVRACIMQKQVPKCNSCKGLIKPMIVFYGEGLPMRFFEHMEKDT 200 Query: 168 SMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQ--VGNEFAEKYYGPASQVV 225 + D+ + IGTS V+P A V +N EP+ + G V Sbjct: 201 KVCDMALVIGTSLLVHPFADLPEIVPNKCQR-VLINREPAGDFGERKKDIMILGDCDSQV 259 Query: 226 PEFVEKL 232 + L Sbjct: 260 RALCKLL 266 >UniRef50_A9NEY3 Putative uncharacterized protein n=1 Tax=Acholeplasma laidlawii PG-8A RepID=A9NEY3_ACHLI Length = 236 Score = 201 bits (511), Expect = 2e-50, Method: Composition-based stats. Identities = 67/232 (28%), Positives = 108/232 (46%), Gaps = 16/232 (6%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLW----EEHRVEDVATPEGFDRDPELVQAFYNAR 58 ++ GAG+S ESGI+ FR+ DGL+ + +R ED+ + F + FY Sbjct: 13 SNYIVFFGGAGVSTESGIKDFRSKDGLYSQKFKNYRPEDILSRSFFFNH---TKDFYEYF 69 Query: 59 RRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRC 118 RR I+PN AH+ L +++G ++TQNID LH+ AG+ NV+ +HG + Sbjct: 70 RRHFLDTGIKPNKAHMWLKD-AESIGKVKCVITQNIDGLHQMAGSKNVVELHGSAHRYYT 128 Query: 119 SQSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMP--LGMDEIYMALSMADIFIAI 176 + Q +D + + ++P VV + E + + +S AD I Sbjct: 129 VKKKQPIDGLTYILNTEDIPVDSEGDLIKPDVVLYEEPLNSEVVRKAIEEISKADTLIVA 188 Query: 177 GTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEF 228 GTS VYPAA F+ K G H + +N E +F G +++ + Sbjct: 189 GTSLTVYPAASFIEYFK--GKHLIVINKE----YMQFKHFIEGQVGEILSQI 234 >UniRef50_Q298C7 GA18650 n=3 Tax=Drosophila RepID=Q298C7_DROPS Length = 381 Score = 201 bits (511), Expect = 2e-50, Method: Composition-based stats. Identities = 52/263 (19%), Positives = 87/263 (33%), Gaps = 40/263 (15%) Query: 4 PRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEG------FDRDPELVQAFYN 56 +++ + GAGIS +GI FR+ GL++ + P F + P Sbjct: 76 KKIITMVGAGISTSAGIPDFRSPGSGLYDNLAKYKLPYPTAIFELGYFKKKPAPFF---- 131 Query: 57 ARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELL 114 A ++L +P AH + L + G TQNID L AG + +I HG Sbjct: 132 ALAKELYPGSFEPTTAHYFIRLLHEK-GLLLRHYTQNIDTLDRLAGIPDEKLIEAHGSFH 190 Query: 115 KVRCSQSGQVLDWTG---DVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDE--IYMALSM 169 C + D ++ + C ++P +V+FGE + Sbjct: 191 TNHCIGCKKEYDMAWMKKEIFSDRLPTCTSCKKIVKPDIVFFGENLPEKFHNSLDGDFKE 250 Query: 170 ADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNE----------------- 212 D+ I +GT+ V+P A +N + Sbjct: 251 CDLLIIMGTTLEVHPFASLAQLPGPRCVRL-LINRDAVGRPKYTTWMDGHNDDFLLYNRP 309 Query: 213 ---FAEKYYGPASQVVPEFVEKL 232 + G + V E + L Sbjct: 310 NNTRDVAFLGDCDEGVLELAKNL 332 >UniRef50_C5M5U2 NAD-dependent histone deacetylase SIR2 n=2 Tax=Candida RepID=C5M5U2_CANTT Length = 499 Score = 201 bits (511), Expect = 2e-50, Method: Composition-based stats. Identities = 68/254 (26%), Positives = 103/254 (40%), Gaps = 30/254 (11%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEH------RVEDVATPEGFDRDPELVQAFYN 56 +++V+TGAGIS GI FR+ GL+ + + V E F +DP L FY Sbjct: 220 AKKIVVITGAGISTSLGIPDFRSFQGLYTQLSKLQLSDPQKVFDMETFKKDPSL---FYT 276 Query: 57 ARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELL 114 + PE + H L L+D TQNIDNL +RAG +I HG Sbjct: 277 IAH-MVLPPEGKFALFHSFLKLLEDK-NKLLRNYTQNIDNLEQRAGISPEKLIQCHGSFS 334 Query: 115 KVRCSQSGQVLDWTGDVTPEDKCHCCQF-------------PAPLRPHVVWFGE-MPLGM 160 +C G + K + ++P + +FGE +P Sbjct: 335 HAKCITCGAIFKGEKIFNHIKKLQVPRCSKCWEDVQEAELIYGVIKPTITFFGEDLPERF 394 Query: 161 DEIY-MALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPS-QVGNEFAEKYY 218 ++ L AD+ I GTS +V P AG V + H + +N + +G+ F + Sbjct: 395 HRLHSKDLKNADMVIVSGTSLNVNPVAGLVEKVPSH-VPKILINKDQIDDMGSLFNLRLI 453 Query: 219 GPASQVVPEFVEKL 232 G +VV + L Sbjct: 454 GLCDEVVAWISKCL 467 >UniRef50_C6X5T5 NAD-dependent protein deacetylase of SIR2 family n=1 Tax=Flavobacteriaceae bacterium 3519-10 RepID=C6X5T5_FLAB3 Length = 230 Score = 201 bits (511), Expect = 2e-50, Method: Composition-based stats. Identities = 106/233 (45%), Positives = 141/233 (60%), Gaps = 9/233 (3%) Query: 4 PRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQ 63 +++VL+GAG SAESG++TFR +DGLWE HR+EDVA+PEGF R+P+ V FYNARRRQL Sbjct: 5 KKLVVLSGAGSSAESGVQTFRDSDGLWENHRIEDVASPEGFARNPQFVLDFYNARRRQL- 63 Query: 64 QPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS-G 122 +QPN AH LAKLQD +++TQN+D+LHE+AG+ NVIH+HGEL K R S Sbjct: 64 -DLVQPNDAHRILAKLQDV--LEVVIITQNVDDLHEKAGSQNVIHLHGELRKARPVDSLT 120 Query: 123 QVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGHV 182 + W D+ D + LRPH+VWFGEM M+ AD F+ +GTS V Sbjct: 121 DIRIWNKDLNIGDLA---EDGTQLRPHIVWFGEMVPEMERAVETAQTADYFLIVGTSMQV 177 Query: 183 YPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKG 235 YPAAG V ++ P + A + A++ + F EKLL+ Sbjct: 178 YPAAGLVSYVPESC-EIFGIDPNPDSQFSAGATFFNTTATEGMRLFKEKLLER 229 >UniRef50_Q7ZVK3 NAD-dependent deacetylase sirtuin-2 n=19 Tax=Eukaryota RepID=SIRT2_DANRE Length = 379 Score = 201 bits (511), Expect = 2e-50, Method: Composition-based stats. Identities = 55/266 (20%), Positives = 90/266 (33%), Gaps = 41/266 (15%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEG------FDRDPELVQAF 54 + ++ + GAGIS +GI FR+ GL+ + ++ PE F + PE F Sbjct: 73 KCKNIICMVGAGISTSAGIPDFRSPGTGLYANLQKYNLPYPEAIFQIDYFKKHPEP---F 129 Query: 55 YNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNT--NVIHMHGE 112 + R L + +P H + L+D G +QNID L AG ++I HG Sbjct: 130 FALARE-LYPGQFKPTVYHYFIKMLKDK-GLLRRCYSQNIDTLERVAGLEGEDLIEAHGT 187 Query: 113 LLKVRCSQ--SGQVLDWTGD---VTPEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYM 165 C + + E+ C + ++P +V+FGE + Sbjct: 188 FHTSHCVSFLCRKEYSMDWMKNQIFSEEIPKCDSCGSLVKPDIVFFGESLPSRFFTSMKA 247 Query: 166 ALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGN-------------- 211 D+ I +GTS V P A V + +N+E + Sbjct: 248 DFPQCDLLIIMGTSLQVQPFASLVSRVSNRC-PRLLINMEKTGQSEFGMGLFSFGGGMDF 306 Query: 212 -----EFAEKYYGPASQVVPEFVEKL 232 + E L Sbjct: 307 DSDKAYRDVAHLSTCDDGCMTLAELL 332 >UniRef50_A9SDL4 SIR2 family protein n=2 Tax=Physcomitrella patens subsp. patens RepID=A9SDL4_PHYPA Length = 323 Score = 200 bits (510), Expect = 2e-50, Method: Composition-based stats. Identities = 85/263 (32%), Positives = 119/263 (45%), Gaps = 29/263 (11%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 +V+VLTGAGISAESGI TFR GLW + ++ATP F +P LV FY+ RR + Sbjct: 47 AKKVVVLTGAGISAESGIPTFRGEGGLWRDFDATELATPGAFAANPSLVWEFYHYRRTIV 106 Query: 63 QQPEIQPNAAHLALAKLQ---DALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCS 119 PNA H A+A LQ LG F+L+TQNID LH +AG+T+V+ +HG L + RC Sbjct: 107 --AGASPNAGHYAVAALQRRCRRLGKDFILLTQNIDGLHAKAGSTDVVELHGSLWETRCC 164 Query: 120 QSGQVLDWTGD-------------------VTPEDKCHCCQFPAPLRPHVVWFGEMPLG- 159 V + C + LRP V+WFGE Sbjct: 165 HCKAVEANRNMPICPALDGKGAPDTVHEANIPSMQLPRCNKCNGLLRPRVIWFGECLERD 224 Query: 160 -MDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYY 218 + AL D+ + +GTS VY + E +LH L L+ ++ + Sbjct: 225 VLRRTDDALQGCDLLLVVGTSAVVYLFWRNMMEVELHTDFVESL-LQDDRLRSRIGLALR 283 Query: 219 GPASQVVPEFVEKLLKGLKAGSI 241 + ++ F K S+ Sbjct: 284 EKSQYLLVAFRR--FKFQGPSSV 304 >UniRef50_C5LN96 Neurofilament triplet L protein, putative n=5 Tax=Perkinsus marinus ATCC 50983 RepID=C5LN96_9ALVE Length = 656 Score = 200 bits (509), Expect = 3e-50, Method: Composition-based stats. Identities = 72/256 (28%), Positives = 99/256 (38%), Gaps = 29/256 (11%) Query: 4 PRVLVLTGAGISAESGIRTFRAAD-GLWEEHR--------VEDVATPEGFDRDPELVQAF 54 RV+VL GAGIS +GI FR+ + G++ + ED+ + F DP F Sbjct: 398 KRVVVLAGAGISVSAGIPDFRSPNTGIYANVKQYTNSLRAPEDLFSIHYFRHDP---YPF 454 Query: 55 YNARRR-QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTN--VIHMHG 111 Y QL + +P AAH +A L + G TQNID+L AG V+ HG Sbjct: 455 YRLCHEAQLGRGAHEPTAAHRFIAWLAEK-GALLRCYTQNIDSLEIDAGVPEELVVQAHG 513 Query: 112 ELLKVRCSQSGQVL--DWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMAL 167 L RC G D ++ E HC ++P VV+FGE D + L Sbjct: 514 HLRSARCIDCGCPYGGDMRDLLSSEKPVHCAACYGLVKPDVVFFGENLPERFFDCVQEDL 573 Query: 168 SMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQV--------GNEFAEKYYG 219 S A + + +GTS V P + +NL P N Sbjct: 574 SQATLLVVMGTSLQVGPCNQIPILLPRT-TPRLLVNLTPPPHGMFRFGRADNYRDVFVEK 632 Query: 220 PASQVVPEFVEKLLKG 235 E +KL K Sbjct: 633 DTDSASEELRKKLEKA 648 >UniRef50_UPI0001744E27 NAD-dependent protein deacetylases, SIR2 family n=1 Tax=Verrucomicrobium spinosum DSM 4136 RepID=UPI0001744E27 Length = 232 Score = 200 bits (509), Expect = 3e-50, Method: Composition-based stats. Identities = 86/229 (37%), Positives = 134/229 (58%), Gaps = 7/229 (3%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 +V+V++GAG+SA SG+ TFR +G W+++R EDVA+P ++R PE+V FYN RR + Sbjct: 7 NSKKVVVISGAGLSAPSGLSTFRDNNGYWKQYRFEDVASPRAWERQPEVVLEFYNERRTK 66 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 ++PNA H A+A+L+D ++VTQN+D+LHERAG+T VIH+HGEL K R + Sbjct: 67 --AASVEPNAGHRAIAELEDRF--EVVVVTQNVDDLHERAGSTRVIHLHGELNKARSTSD 122 Query: 122 GQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGH 181 ++ G C + + LRPH+VWFGE +D ++ A + +GTS Sbjct: 123 ESLVYELGARPIALGDLCEK-GSQLRPHIVWFGEEVKAIDLAADEVASAGRVLVVGTSLK 181 Query: 182 VYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVE 230 VYPAAG A + ++L+ + +F G A ++P+ ++ Sbjct: 182 VYPAAGLCSCAHEYATK-FYVDLDAKRQVPDFT-VIQGSAEVILPDLLK 228 >UniRef50_B3L8U3 Transcriptional regulatory protein sir2 homologue, putative n=6 Tax=Plasmodium RepID=B3L8U3_PLAKH Length = 301 Score = 200 bits (509), Expect = 4e-50, Method: Composition-based stats. Identities = 66/244 (27%), Positives = 105/244 (43%), Gaps = 15/244 (6%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADG-LWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 E V+ LTG+G SAES I +FR + +W ++ + T GF + PE + R Sbjct: 27 ECTYVVALTGSGTSAESNIPSFRGDNSSIWSKYDPKIYGTIWGFWKSPE---KIWEVIRD 83 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 EI+ N H AL+ L+ +LG ++TQNID LHE +GN+ VI +HG + + RC Sbjct: 84 ISSDYEIELNPGHTALSTLE-SLGYLKAVITQNIDGLHEESGNSKVIPLHGSVFEARCCT 142 Query: 121 SGQVLDWTGD------VTPEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMADI 172 + + C +P+VV FGE+ + + + D+ Sbjct: 143 CRETIQLNKIMLQKTSHFMHQLPPECPCGGIFKPNVVLFGEVIPKSLLKQAQKEIENCDL 202 Query: 173 FIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNE-FAEKYYGPASQVVPEFVEK 231 + +GTS V A + A VE+N+ + + N S +V + Sbjct: 203 LLVVGTSSSVSTATNLCYYAHRKKKKIVEVNISKTYITNRLSDCHVRAKFSDLVT-ISDI 261 Query: 232 LLKG 235 L Sbjct: 262 LKGE 265 >UniRef50_C9M9P4 Transcriptional regulator, Sir2 family n=1 Tax=Jonquetella anthropi E3_33 E1 RepID=C9M9P4_9BACT Length = 250 Score = 199 bits (507), Expect = 5e-50, Method: Composition-based stats. Identities = 63/239 (26%), Positives = 99/239 (41%), Gaps = 13/239 (5%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEE--HRVEDVATPEGFDRDPELVQAFYNARRR 60 R + TGAG+S ++G+ FR +GL+ + + F DP F+ R+ Sbjct: 17 SRRAVAFTGAGVSTDAGLPDFRGPNGLYRRSDVDASRLFDIDAFYEDPSYYYRFHRQLRK 76 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 L I+P H LA+ + + G LVTQN D LHE AG+ V +HG + C + Sbjct: 77 IL--AGIRPTVTHRFLAQWEQS-GRLAALVTQNFDGLHEAAGSKRVFPVHGTVATNTCLR 133 Query: 121 SGQVLDWT--GDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGT 178 G+ + E C ++P VV+FGE + E + A AD + +GT Sbjct: 134 CGRGFSAAQLDEFLAEQGVPHCPCGGVIKPDVVFFGESVKFLSESFAAAEAADFMLVLGT 193 Query: 179 SGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFA-EKYYGPASQVVPEFVEKLLKGL 236 S V PA A V +N + + E + +F +L + + Sbjct: 194 SLTVAPACSVPALCP---APVVIVNKGAVHLSYPRSREILQADCD--LDDFFTQLSRLV 247 >UniRef50_C4QWX8 Conserved NAD+ dependent histone deacetylase of the Sirtuin family n=1 Tax=Pichia pastoris GS115 RepID=C4QWX8_PICPG Length = 520 Score = 199 bits (507), Expect = 6e-50, Method: Composition-based stats. Identities = 65/282 (23%), Positives = 97/282 (34%), Gaps = 60/282 (21%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEH------RVEDVATPEGFDRDPELVQAFYN 56 +LVLTGAGIS GI FR+++G + + + V E F +DP L FY+ Sbjct: 181 SKNILVLTGAGISTSLGIPDFRSSEGFYTKLQEQGLDDPQTVFDLEYFKQDPSL---FYS 237 Query: 57 ARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELL 114 + PE H + L D G TQNIDNL AG + VI HG Sbjct: 238 IAH-LVLPPEGSFTPLHGFIKLLADK-GSLLRNYTQNIDNLEANAGIPSEKVIQCHGSFA 295 Query: 115 KVRCSQSGQVLD---WTGDVTPEDKCHCCQF----------------------------- 142 C + ++ + C Sbjct: 296 TASCITCKYKIPGETIFEEIRNSELPLCPFCIKRRQKLIKEIEALDDSEQGISRHSFSFL 355 Query: 143 -----------PAPLRPHVVWFGEMPLGM--DEIYMALSMADIFIAIGTSGHVYPAAGFV 189 ++P + +FGE + D I + D+ + IGTS V P + V Sbjct: 356 GSTVKRSYAESYGVMKPDITFFGEDLPRVFHDNIIQDVKNCDLLLCIGTSLKVAPVSEIV 415 Query: 190 HEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEK 231 ++ K V +N +P EF G +++ E Sbjct: 416 NKVKPE-IPQVLINKDPVTHT-EFDISLLGYCDELIVYLCEA 455 >UniRef50_UPI00019255E8 PREDICTED: similar to sirtuin n=2 Tax=Hydra magnipapillata RepID=UPI00019255E8 Length = 320 Score = 199 bits (507), Expect = 6e-50, Method: Composition-based stats. Identities = 69/265 (26%), Positives = 110/265 (41%), Gaps = 42/265 (15%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 +V V+TGAG+S ESGI+ +R+ GL+ + + E F ++P Q ++ R Sbjct: 54 NCSKVFVITGAGVSTESGIKDYRSDKVGLYATSKQRPIEYLE-FLKNPNKRQKYW--ARN 110 Query: 61 QLQQP---EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVR 117 L P QPN H L+ ++ G+ LVTQN+D+LH +AG+ V +HG +V Sbjct: 111 YLAWPIFSSFQPNVNHHFLSAMEKH-GNLHWLVTQNVDSLHLKAGSVRVTELHGSSARVV 169 Query: 118 CSQSGQVLDWTG--------------------------------DVTPEDKCHCCQFPAP 145 C G + D + C + Sbjct: 170 CLTCGNKISRVELQKQLQHINSNWRSISSLNEQGPDGDVFISESDASQFKMVDCHKCGGI 229 Query: 146 LRPHVVWFGEM--PLGMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELN 203 L+P +V+FG+ P + Y LS D + IG+S VY + F+ AK LN Sbjct: 230 LKPEIVFFGDNVSPTVKEFCYKMLSECDGVLVIGSSLQVYSSFRFIIAAKEKRIPIAILN 289 Query: 204 LEPSQVGNEFAEKYYGPASQVVPEF 228 + ++ K A +V+P+ Sbjct: 290 IGETRGDPYAYLKLPYRAGEVLPKL 314 >UniRef50_Q8N6T7 NAD-dependent deacetylase sirtuin-6 n=24 Tax=Metazoa RepID=SIRT6_HUMAN Length = 355 Score = 199 bits (506), Expect = 7e-50, Method: Composition-based stats. Identities = 56/247 (22%), Positives = 92/247 (37%), Gaps = 36/247 (14%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 + V+ TGAGIS SGI FR G+W T E P+ F Sbjct: 43 QSSSVVFHTGAGISTASGIPDFRGPHGVW---------TMEERGLAPKFDTTF------- 86 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELLKVRCS 119 +P H+AL +L+ +G LV+QN+D LH R+G + +HG + C+ Sbjct: 87 ---ESARPTQTHMALVQLE-RVGLLRFLVSQNVDGLHVRSGFPRDKLAELHGNMFVEECA 142 Query: 120 QSGQVLDWTGDVTPE------------DKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYM 165 + V LR ++ + + + Sbjct: 143 KCKTQYVRDTVVGTMGLKATGRLCTVAKARGLRACRGELRDTILDWEDSLPDRDLALADE 202 Query: 166 ALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVV 225 A AD+ I +GTS + P+ K G V +NL+P++ + +G +V+ Sbjct: 203 ASRNADLSITLGTSLQIRPSGNLPLATKRRGGRLVIVNLQPTKHDRHADLRIHGYVDEVM 262 Query: 226 PEFVEKL 232 ++ L Sbjct: 263 TRLMKHL 269 >UniRef50_C0W513 NAD-dependent deacetylase 1 n=4 Tax=Actinomycetaceae RepID=C0W513_9ACTO Length = 291 Score = 199 bits (506), Expect = 8e-50, Method: Composition-based stats. Identities = 70/268 (26%), Positives = 107/268 (39%), Gaps = 40/268 (14%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 M R L +TGAG+S ++GI +R + + F DP + + Sbjct: 30 MAGRRTLAVTGAGMSTDAGIPDYRGLG-----TTPVEPVDFQQFVSDPVWYRWVWACNHA 84 Query: 61 QLQQPEI-QPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCS 119 Q E +P H ALA+L++A G + TQN+D LH RAG + V +HG +V C Sbjct: 85 TWQLLEPLRPTPGHRALARLEEA-GYLTGVATQNVDRLHSRAGQSTVWELHGAYDRVVCL 143 Query: 120 QSGQVLDWTG--------------------------------DVTPEDKCHCCQFPAPLR 147 + G+VL + C + L+ Sbjct: 144 ECGRVLTRAEVDQRLSALNPDYPRQSDPARVAITPEADRAAAEACSFQTVTCSKCSGLLK 203 Query: 148 PHVVWFGE-MPLGMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEP 206 P +V+FGE +P M++ A D+ IA GTS V V +A GA V +N P Sbjct: 204 PDIVFFGESLPPAMEKAMQAAGECDVVIAAGTSLAVLTGLWIVRQAVAKGADLVVINRGP 263 Query: 207 SQVGNEFAEKYYGPASQVVPEFVEKLLK 234 + + G SQV+ ++L + Sbjct: 264 TAADELATIRVEGGTSQVLAAVADRLAR 291 >UniRef50_D2VK77 Putative uncharacterized protein n=1 Tax=Naegleria gruberi RepID=D2VK77_NAEGR Length = 469 Score = 199 bits (506), Expect = 8e-50, Method: Composition-based stats. Identities = 58/252 (23%), Positives = 101/252 (40%), Gaps = 22/252 (8%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADG-----LWEEHRVEDVATPEGFDRDPELVQAFYN 56 ++L LTGAGIS ESGI FR + +WE+ +++ + F Sbjct: 211 NSSKILGLTGAGISVESGISAFRNSGNSQLQNIWEKWNQDEMTYQNILSKKKIRDDYFEM 270 Query: 57 ARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELL 114 + Q + +PN +H A+L++ G ++TQNID +H++AG + VI +HG Sbjct: 271 HAFLKEQISKAEPNGSHHLFAQLKEK-GKLLKVITQNIDGMHQKAGLSDDKVIEIHGSSR 329 Query: 115 KVRCSQSGQVLDWTGDVTPE------------DKCHCCQFPAPLRPHVVWFGEMPLGMD- 161 V C++ +++ + + D+ C+ L+P+ + FGE Sbjct: 330 GVVCTKCRTLVEDPEKIYSQVKDCVLEGKSLPDELVTCKCGGVLKPNTISFGEELQDSKL 389 Query: 162 -EIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGP 220 E D+ I +GT V P V +NLE + G Sbjct: 390 IEARQQCRECDLMIIMGTRLLVSPVNQLPKLVAARNVPVVIINLESTPFDRNSVAVMNGK 449 Query: 221 ASQVVPEFVEKL 232 + + + +L Sbjct: 450 SGETCNYILHRL 461 >UniRef50_A8PNK8 Transcriptional regulator, Sir2 family protein n=1 Tax=Brugia malayi RepID=A8PNK8_BRUMA Length = 399 Score = 199 bits (506), Expect = 8e-50, Method: Composition-based stats. Identities = 59/266 (22%), Positives = 89/266 (33%), Gaps = 41/266 (15%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAAD-GLWEEH------RVEDVATPEGFDRDPELVQAF 54 E ++VLTGAGIS +G+ FR+ GL++ + F + PE F Sbjct: 78 EVKNIIVLTGAGISTSAGVPDFRSPGTGLYDNLSQYNLPDPMAIFDISYFKKHPEP---F 134 Query: 55 YNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGE 112 Y + ++P H + L D G TQNID+L G ++ HG Sbjct: 135 YKLAKDLF-PSHLKPTPCHYLIR-LMDEKGLLLRWYTQNIDSLEFVTGINEDKLVTAHGC 192 Query: 113 LLKVRCSQSGQVLDWTGDV-----TPEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYM 165 C D + HC + ++P +V+FGE + Sbjct: 193 HHTSTCLSCRAKFDLNWIMNKVFVEHVKVAHCDKCGGIVKPDIVFFGENLPARFFNYSIR 252 Query: 166 ALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEP------------------- 206 D+ I +GTS V+P AG V E + +NL Sbjct: 253 DFPKCDLLIIMGTSLVVHPFAGLVDEVND-DVPRLLINLTEAGHSTSSLFPYGGSSGLCY 311 Query: 207 SQVGNEFAEKYYGPASQVVPEFVEKL 232 N + G + E L Sbjct: 312 HDKDNYRDVFWQGTTDDGAWKLAELL 337 >UniRef50_A3LRA1 Transcriptional regulatory protein n=4 Tax=Saccharomycetales RepID=A3LRA1_PICST Length = 311 Score = 198 bits (505), Expect = 1e-49, Method: Composition-based stats. Identities = 76/299 (25%), Positives = 124/299 (41%), Gaps = 67/299 (22%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 +++ L GAG+S SG+ TFR + GLW+ + D+ATP+ F DP LV FY+ RR Sbjct: 15 CRKIVALVGAGLSVSSGLPTFRGSQGLWKNFNMIDLATPDAFYIDPGLVWQFYSWRR--Y 72 Query: 63 QQPEIQPNAAHLALAKLQ-----DALGDRFLLVTQNIDNLHERAGN--TNVIHMHGELLK 115 + +PN HLAL+ L ++ +TQN+D L R+G+ N+ +HG L Sbjct: 73 NALQAKPNKGHLALSALSNLATRKDSNLEYITITQNVDGLSSRSGHAKENLYEIHGSLFN 132 Query: 116 VRCSQ--S-----------------GQVLDWTGDVTPE---------------------- 134 + C+ G ++ Sbjct: 133 LNCTSFMCNYVDRNNLKHPLTKALEGTEYEYDRKNRKRSLEEDDSSHQVDYSISPQFRPV 192 Query: 135 --------DKCHCCQFPAPLRPHVVWFGEMPL-----GMDEIYMALSMADIFIAIGTSGH 181 +C C+ + LRP VVWFGE +D + + D+ + IGTSG Sbjct: 193 KNIPESELPQCPVCKDGSLLRPGVVWFGESLPLNVMNSVDNFIESNNSVDLILVIGTSGT 252 Query: 182 VYPAAGFVHEAKLHGAHTVELNLEPS----QVGNEFAEKYYGPASQVVPEFVEKLLKGL 236 VYPA +V K+ G N + Q + + G A++++P ++ ++ + Sbjct: 253 VYPANSYVDRVKVKGGKVAIFNTDIEEDILQGIVKDTWGFRGDAAELLPIALKPVIGEV 311 >UniRef50_Q5HU51 NAD-dependent deacetylase n=15 Tax=Campylobacter RepID=NPD_CAMJR Length = 233 Score = 198 bits (504), Expect = 1e-49, Method: Composition-based stats. Identities = 78/240 (32%), Positives = 132/240 (55%), Gaps = 10/240 (4%) Query: 4 PRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQ 63 +++L+GAG+SA SG++TFR DGLWEE+ V +V + GF ++P+ V FY+ARR QLQ Sbjct: 2 KNIMILSGAGLSAPSGLKTFRDNDGLWEEYDVMEVCSATGFRKNPKKVLDFYDARRVQLQ 61 Query: 64 QPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQ 123 ++PN AH +A+L++ G ++TQN+D+L ERAG +V+H+HG L ++RC + Sbjct: 62 --NVKPNHAHEKIAQLKEKWGKNLFVITQNVDDLLERAGCKDVVHLHGFLPELRCLKCEG 119 Query: 124 VLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGHVY 183 + + + + +C C+ LR ++V F E +Y L+ +FI+IGTSG V Sbjct: 120 IFNIGYEKIIDKQCPKCKSKD-LRHNIVMFEEQAPAYATLYSLLNQTSLFISIGTSGAVL 178 Query: 184 PAAGFVHEAKLHGAHTVELNLEP--SQVGNEFAEKYYGPASQVVPEFVEKLLKGLKAGSI 241 P + + LN+ + + F + Y + + + +K G++ Sbjct: 179 PVGRYASMCEKS-----ILNIYEKDANLERYFDKIYIEDIINAIDKIALDIENFMKDGNV 233 >UniRef50_A4S2L7 Predicted protein n=2 Tax=Ostreococcus RepID=A4S2L7_OSTLU Length = 329 Score = 198 bits (503), Expect = 2e-49, Method: Composition-based stats. Identities = 64/267 (23%), Positives = 92/267 (34%), Gaps = 44/267 (16%) Query: 4 PRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEG------FDRDPELVQAFYNA 57 V+V+TGAGIS +GI FR+ GL+ D+ P+ F PE FY Sbjct: 43 KNVVVMTGAGISVSAGIPDFRSERGLYARLGEYDLPYPQAIFELGYFREKPEA---FYKL 99 Query: 58 RRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELLK 115 + L P H + L D G TQNID+L G V+ HG Sbjct: 100 AKD-LYPGLYAPTPTHYFIKLLHDR-GLLRRCFTQNIDSLECATGLPKDKVVAAHGNFDS 157 Query: 116 VRCS--QSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMAD 171 +C + + C + ++P +V+FGE + + D Sbjct: 158 AKCLNGHDANIYEVERACRAGTPMTCAKCGEFVKPDIVFFGENLPRRFFECAQKDFEVCD 217 Query: 172 IFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEP---------------------SQVG 210 + I IGTS V+P AG + K H + +NLE + Sbjct: 218 LLIVIGTSLVVHPFAGLIERPKEH-VPRLLINLERCGEAQNTRVTKLYRMAGLGRGTGFD 276 Query: 211 -----NEFAEKYYGPASQVVPEFVEKL 232 N + G V E L Sbjct: 277 FDEATNYRDALFLGQCDDGVAELCSML 303 >UniRef50_B9L4G7 NAD-dependent deacetylase 1 (Regulatory protein SIR2homolog 1) n=2 Tax=Thermomicrobia (class) RepID=B9L4G7_THERP Length = 282 Score = 198 bits (503), Expect = 2e-49, Method: Composition-based stats. Identities = 66/217 (30%), Positives = 97/217 (44%), Gaps = 11/217 (5%) Query: 7 LVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQ-QP 65 + TGAGIS ESGI +R +GLW F DPE+ + +++ RR++ Sbjct: 41 MAFTGAGISTESGIPDYRGPNGLWSRENPTRYRD---FLNDPEVRRRYWDRRRQRYPILA 97 Query: 66 EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGN--TNVIHMHGELLKVRCSQSGQ 123 +PN H+ALA+LQ A G ++VTQNID LH++AG+ V+ +HG +RC Sbjct: 98 GARPNVGHVALARLQ-AAGYLEIIVTQNIDGLHQKAGSPPERVVELHGTAHAIRCLSCEL 156 Query: 124 VLDWTGDVTPED--KCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMADIFIAIGTS 179 + C ++ V FGE ++ + + IGTS Sbjct: 157 LWPAEEFDPGPPGTIPDCPVCGGLVKEATVSFGEPVPRRILEHALALAEATPVMLVIGTS 216 Query: 180 GHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEK 216 V PAA A GA +N EP+ + E A Sbjct: 217 LKVVPAAHVPRRAARAGAFVAIVNDEPTPLDREAAVV 253 >UniRef50_C4XFR7 Putative uncharacterized protein n=1 Tax=Mycoplasma fermentans PG18 RepID=C4XFR7_MYCFE Length = 251 Score = 197 bits (502), Expect = 2e-49, Method: Composition-based stats. Identities = 66/225 (29%), Positives = 105/225 (46%), Gaps = 15/225 (6%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLW----EEHRVEDVATPEGFDRDPELVQAFYNA 57 E ++ +GAG+S SGI FR+ADGL+ + E + + + ++ + FY Sbjct: 18 ESKHIVFFSGAGVSTASGIPDFRSADGLYSKKFKNMNPESILSRSFWRKNKK---DFYEY 74 Query: 58 RRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVR 117 + I+PN H +A + ++TQNIDNL +AGN VI +HG + + Sbjct: 75 YFSNIAFDNIKPNIIHETVASWCNKNK--CHVITQNIDNLDIKAGNKYVIELHGNINRNY 132 Query: 118 CSQSGQVLDWTGDVTPEDK--CHCCQFPAPLRPHVVWFGE--MPLGMDEIYMALSMADIF 173 C G+ D + +DK C+ + P VV + + M ++ A+S +D+ Sbjct: 133 CLLCGKFYDLAQLIHQKDKDGIPTCKCGGVINPDVVLYEDPLMEDSTNDAAEAISNSDLL 192 Query: 174 IAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYY 218 I GTS VYPAA ++H G V LN + S+ N E Sbjct: 193 IIAGTSLSVYPAASYIHF--YQGKRIVILNKDTSRYENSNNENIL 235 >UniRef50_C4M6Q0 Sir2 family transcriptional regulator, putative n=2 Tax=Entamoeba RepID=C4M6Q0_ENTHI Length = 359 Score = 197 bits (502), Expect = 2e-49, Method: Composition-based stats. Identities = 57/243 (23%), Positives = 94/243 (38%), Gaps = 18/243 (7%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAAD-GLWEEHR------VEDVATPEGFDRDPELVQAF 54 + V+V+ GAGIS +GI FR GL++ V F +P+ F Sbjct: 101 KPSNVVVMAGAGISTSAGIPDFRTPGTGLYDNLEAYNLPFPTAVFDINYFKSNPKP---F 157 Query: 55 YNARRRQLQ-QPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHG 111 Y + + P H L L + LG +L TQNID L ++G N ++ HG Sbjct: 158 YTIASELMPGLGKYFPTPTHYFLTYL-NKLGYISMLFTQNIDGLEIQSGFPNEKLVMAHG 216 Query: 112 ELLKVRCSQSGQVL---DWTGDVTPEDKCHCCQFPAPLRPHVVWFGE-MPLGMDEIYMAL 167 C + + + +V C+C ++P +V+FGE +P + + Sbjct: 217 NYYSGHCLKCKKSFKQSYFIDNVRDGKVCYCDSCKGLVKPDIVFFGEGLPQQFFNNFEKV 276 Query: 168 SMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPE 227 D+ I +GTS V P A + K + + + + G + + E Sbjct: 277 EECDLLIVLGTSLLVQPFASLIDLTKKNTPRVYINMKDFNSFNKINDLQIIGKCDESILE 336 Query: 228 FVE 230 E Sbjct: 337 IAE 339 >UniRef50_C5MB00 NAD-dependent histone deacetylase SIR2 n=2 Tax=Saccharomycetales RepID=C5MB00_CANTT Length = 601 Score = 197 bits (502), Expect = 2e-49, Method: Composition-based stats. Identities = 66/263 (25%), Positives = 97/263 (36%), Gaps = 39/263 (14%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEH------RVEDVATPEGFDRDPELVQAFY 55 + ++LV+TGAGIS GI FR++ G + ++V E F DP L FY Sbjct: 250 KSNKILVITGAGISTSLGIPDFRSSKGFYSMVQHLGLSDPQEVFDLELFHIDPSL---FY 306 Query: 56 NARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGEL 113 + + PE + H + LQD G TQNIDNL AG ++ HG Sbjct: 307 SIAH-MILPPEKMFSPMHSFIRVLQDH-GKLLRNYTQNIDNLESYAGISKEKLVQCHGSF 364 Query: 114 LKVRCSQSGQVL---DWTGDVTPEDKCHCCQF-------------------PAPLRPHVV 151 C G + D + ++ C Q +P + Sbjct: 365 ATASCVTCGYRINGEDIFDKIRAKEIPLCQQCTKHKTDILKRDEDYYFADSYGVFKPDIT 424 Query: 152 WFGEMPLG--MDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQV 209 +FGE D I + D+ I GTS V P + V + + +N + Sbjct: 425 FFGEALPSNFHDHIREDILECDLLICAGTSLKVAPVSDIVDKVPEK-IPQILINKDSITH 483 Query: 210 GNEFAEKYYGPASQVVPEFVEKL 232 N F G +VV +KL Sbjct: 484 CN-FDVSLLGYCDEVVSYVADKL 505 >UniRef50_B7U9B0 Sirtuin 3 n=7 Tax=Chordata RepID=B7U9B0_PIG Length = 257 Score = 197 bits (501), Expect = 3e-49, Method: Composition-based stats. Identities = 63/241 (26%), Positives = 94/241 (39%), Gaps = 23/241 (9%) Query: 9 LTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEG------FDRDPELVQAFYNARRRQ 61 + GAGIS SGI FR+ G + + D+ PE F +P+ F ++ Sbjct: 1 MVGAGISTPSGIPDFRSPGTGYYSTLQSYDLPYPEAIFELSFFFHNPKPFFTF----AKE 56 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGN--TNVIHMHGELLKVRCS 119 L +PN AH L L D G L TQNID L +G + ++ HG C+ Sbjct: 57 LYPGNYRPNTAHYFLRLLHDK-GLLLRLYTQNIDGLERASGIPASKLVEAHGSFASATCT 115 Query: 120 QSGQVL---DWTGDVTPEDKCHCCQFPAPLRPHVVWFGE-MPLGMDEIYMALSMADIFIA 175 + D+ DV + C ++P +V+FGE +P +AD+ + Sbjct: 116 VCRRPFPGEDFWADVMVDSVPRCRVCAGVVKPDIVFFGEPLPPRFLLHLADFPVADLLLI 175 Query: 176 IGTSGHVYPAAGFVHEAKLHGAHTVELNLEPS----QVGNEFAEKYYGPASQVVPEFVEK 231 +GTS V P A EA + +N + + G V VE Sbjct: 176 LGTSLEVEPFASL-SEAVRSSVPRLLINRDLVGTLARHPRGRDVVQLGDLVHGVKRLVEL 234 Query: 232 L 232 L Sbjct: 235 L 235 >UniRef50_O59923 NAD-dependent histone deacetylase SIR2 n=4 Tax=Candida albicans RepID=SIR2_CANAL Length = 515 Score = 197 bits (501), Expect = 3e-49, Method: Composition-based stats. Identities = 59/258 (22%), Positives = 95/258 (36%), Gaps = 30/258 (11%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEH------RVEDVATPEGFDRDPELVQAFY 55 +++V+TGAGIS GI FR+ GL+ + + V + F R+ L FY Sbjct: 233 RAKKIMVVTGAGISTSLGIPDFRSFKGLYNQLSKLNLSDPQKVFDLQTFMREGRL---FY 289 Query: 56 NARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGEL 113 + P+ + + H L LQD TQNIDNL +RAG + ++ HG Sbjct: 290 TIAH-LVLPPDGKFSLLHAFLKLLQDKH-KLLRNYTQNIDNLEQRAGLKSEKLVQCHGSF 347 Query: 114 LKVRCSQSGQVLDWTGDVTPEDKCHCCQFPAP-------------LRPHVVWFGEMPLGM 160 K +C + + + ++P + +FGE Sbjct: 348 AKAKCVSCQGIFAGEKIYNHIRRKQVPRCAICWKNTKQAPIHFGAIKPTITFFGEDLPER 407 Query: 161 DE--IYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYY 218 + L D+F+ IGTS V P A + + +N +P F + Sbjct: 408 FHTLMDKDLQQIDLFLVIGTSLKVEPVASIIERVPYK-VPKILINKDPIP-NRGFNLQLL 465 Query: 219 GPASQVVPEFVEKLLKGL 236 G V + L + Sbjct: 466 GLCDDAVSYLCKCLKWDI 483 >UniRef50_C5GPX3 SIR2 family histone deacetylase n=2 Tax=Ajellomyces dermatitidis RepID=C5GPX3_AJEDR Length = 341 Score = 197 bits (500), Expect = 4e-49, Method: Composition-based stats. Identities = 82/280 (29%), Positives = 117/280 (41%), Gaps = 46/280 (16%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 R+L L GAG+SA SGI T+ W H V + T F DP V FY+ RRR Sbjct: 62 SKRILTLLGAGLSAASGIGTYVDEGRFWRTHNVRRLCTYGAFREDPSRVWWFYSDRRR-- 119 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNT--NVIHMHGELLKVRCSQ 120 + +PN AH ALAKL LG+ L V QNID L RAG + +++HG+ ++CS Sbjct: 120 GAMKAEPNKAHYALAKLARKLGNGMLTVCQNIDRLCPRAGQPETSTVYLHGDYFTIKCSS 179 Query: 121 SGQVLDWTGD-------------------------VTPEDKCHCCQFPAPLRPHVVWFGE 155 D V E C + LRP V WFGE Sbjct: 180 ESCTYSRADDNDPIVPALTLPSTHSISDPDFPLPHVPEESLPRCPSCSSLLRPGVTWFGE 239 Query: 156 -MPLGM-DEIYMALSM----------ADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELN 203 MP ++ L D+ + IGT+ V+P V +A+ GA +N Sbjct: 240 TMPPAQTKRVHDWLQQIDRDPESNGHIDLVLVIGTAATVHPVLSLVTQARKKGAKVCVVN 299 Query: 204 L-----EPSQVGNEFAEKYYGPASQVVPEFVEKLLKGLKA 238 + +E + G A +V+PE ++++ + Sbjct: 300 PDRESAQKVGGMDEGNWWFRGGAEEVLPEIFKEVIGDAEE 339 >UniRef50_A8NIK3 Putative uncharacterized protein n=1 Tax=Coprinopsis cinerea okayama7#130 RepID=A8NIK3_COPC7 Length = 313 Score = 196 bits (499), Expect = 5e-49, Method: Composition-based stats. Identities = 81/290 (27%), Positives = 118/290 (40%), Gaps = 68/290 (23%) Query: 3 KPRVLVLTGAGISAESGIRTFRA-ADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 +V +L GAG+SA SGI T+R D +W+ + +AT EGF++DP F++ R+ Sbjct: 17 SKQVAILAGAGLSAGSGIPTYRGGPDAIWKNMDHDKLATVEGFEKDPVTCWQFHHMMRQL 76 Query: 62 LQQPEIQPNAAHLALAKL------------QDALGDRFLLVTQNIDNLHERA-------- 101 + PNAAH ALA L L +TQN+D+L R Sbjct: 77 CL--DATPNAAHRALASLVVPSVRAKVLPGLKDPDSPPLFITQNMDSLSPRTLDEFKDKI 134 Query: 102 -------GNTNVIHMHGELLKVRCSQSGQVLDWTGDV----------------------- 131 ++ MHG + + +C Q V T Sbjct: 135 SSGEMEKAKERLVEMHGNIFRQKCLQCKHVSTSTDSHLAPGRYPKDANSPATARLEGTNP 194 Query: 132 ----TPEDKCHCC-----------QFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAI 176 + +D C + PLRP VVWFGE+P G+ +I LS D+ I + Sbjct: 195 SATVSKDDLPRCGGPSWNGSNRYGRCGGPLRPSVVWFGEIPEGLGDIARHLSWTDMLIVV 254 Query: 177 GTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVP 226 GTS V+PAAGF+ K G N + S + + G +V+P Sbjct: 255 GTSCLVHPAAGFLKTVKDRGGKVAIFNYDASPKDDLADFLFLGKCEEVLP 304 >UniRef50_Q8IXJ6 NAD-dependent deacetylase sirtuin-2 n=43 Tax=Chordata RepID=SIRT2_HUMAN Length = 389 Score = 196 bits (499), Expect = 5e-49, Method: Composition-based stats. Identities = 62/275 (22%), Positives = 97/275 (35%), Gaps = 44/275 (16%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAA-DGLWEEHRVEDVATPEG------FDRDPELVQAF 54 RV+ L GAGIS +GI FR+ GL++ + PE F + PE Sbjct: 75 RCRRVICLVGAGISTSAGIPDFRSPSTGLYDNLEKYHLPYPEAIFEISYFKKHPEPFF-- 132 Query: 55 YNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGE 112 A ++L + +P H + L+D G TQNID L AG +++ HG Sbjct: 133 --ALAKELYPGQFKPTICHYFMRLLKDK-GLLLRCYTQNIDTLERIAGLEQEDLVEAHGT 189 Query: 113 LLKVRCSQ--SGQVLDWTGD---VTPEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYM 165 C + + E C + ++P +V+FGE + Sbjct: 190 FYTSHCVSASCRHEYPLSWMKEKIFSEVTPKCEDCQSLVKPDIVFFGESLPARFFSCMQS 249 Query: 166 ALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEF------------ 213 D+ + +GTS V P A + +A L + +N E + + F Sbjct: 250 DFLKVDLLLVMGTSLQVQPFASLISKAPLS-TPRLLINKEKAGQSDPFLGMIMGLGGGMD 308 Query: 214 --------AEKYYGPASQVVPEFVEKL--LKGLKA 238 + G Q E L K L+ Sbjct: 309 FDSKKAYRDVAWLGECDQGCLALAELLGWKKELED 343 >UniRef50_B3RZX6 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens RepID=B3RZX6_TRIAD Length = 337 Score = 196 bits (498), Expect = 6e-49, Method: Composition-based stats. Identities = 61/274 (22%), Positives = 93/274 (33%), Gaps = 49/274 (17%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAAD-GLWEEH-------RVEDVATPEGFDRDPELVQA 53 E ++V+TGAG+S +GI FR+ D GL+ + E V + + F +P + Sbjct: 43 ECKNIIVMTGAGLSTAAGIPDFRSPDIGLFTKVMQKYQVTSPELVFSIDYFHENPSV--- 99 Query: 54 FYNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHG 111 FY R + + +P AH L L D TQN+D L AG V+ HG Sbjct: 100 FYEMSRGM-TETDYKPTIAHYFLKLLADK-NLLLRHYTQNVDGLDLAAGLSEDKVVTAHG 157 Query: 112 ELLKVRCS--QSGQVLDWTG------DVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEI 163 + C+ + C + ++P VV +GE Sbjct: 158 TMYTAHCTTSECHTKYTLEWLKQQLLKTPDITVPRCDKCQGVIKPDVVLYGEQLPNKFFT 217 Query: 164 YM--ALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVG----------- 210 D+ I +GTS V P A V H A + +NLE + Sbjct: 218 MRSADFPNCDLLIIMGTSLKVEPFASLVEHVPEH-APRLLINLEETGQDHGMFSRSPSQI 276 Query: 211 ------------NEFAEKYYGPASQVVPEFVEKL 232 N + G + + L Sbjct: 277 GGMVKHLLGWNSNRKDIFWKGSCDDGCLKLADLL 310 >UniRef50_Q4UZX0 NAD-dependent deacetylase n=94 Tax=Bacteria RepID=NPD_XANC8 Length = 293 Score = 196 bits (498), Expect = 6e-49, Method: Composition-based stats. Identities = 70/262 (26%), Positives = 103/262 (39%), Gaps = 41/262 (15%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 R+ VL+GAG S +SGI +R G W+ + T + F + Q ++ R Sbjct: 18 RHQRLFVLSGAGCSTDSGIPDYRDLQGGWKRPQPV---TFQAFMGELSTRQRYW--ARSL 72 Query: 62 LQQPE---IQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRC 118 + P +PNA H ALA L+ G LL+TQN+D LH+ AG+ VI +HG L VRC Sbjct: 73 VGWPRFGLARPNATHHALAALEAR-GQLELLLTQNVDRLHQAAGSQAVIDLHGRLDVVRC 131 Query: 119 SQSGQVLDWTG------------------------------DVTPEDKCHCCQFPAPLRP 148 Q + T C L+P Sbjct: 132 MGCEQRMPRTEFQLLLERDNPGWADLEAAQAPDGDADLDNVAFDNFVVPACPACGGVLKP 191 Query: 149 HVVWFGEMPL--GMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEP 206 VV+FGE ++ + L AD + +G+S VY FV A G LN Sbjct: 192 DVVFFGENVPRERVERAFAHLQAADAVLVVGSSLMVYSGFRFVQAAARAGLPIAALNFGR 251 Query: 207 SQVGNEFAEKYYGPASQVVPEF 228 ++ + + K +Q + Sbjct: 252 TRADDLLSLKVEQSCAQALAFL 273 >UniRef50_A7SK95 Predicted protein n=1 Tax=Nematostella vectensis RepID=A7SK95_NEMVE Length = 323 Score = 196 bits (498), Expect = 7e-49, Method: Composition-based stats. Identities = 76/263 (28%), Positives = 116/263 (44%), Gaps = 40/263 (15%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 E P++ V+TGAGIS ESGIR +R+ GL+ + + F + + Q ++ R Sbjct: 59 ENPKIFVITGAGISTESGIRDYRSEGKGLYAITNDRPM-EYQVFLKSAVMRQRYW--ARN 115 Query: 61 QLQQPEI---QPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVR 117 + PE QPN AH ALAKL+ LG LVTQN+D LH +AG+ NVI +HG +V Sbjct: 116 YVGWPEFGSRQPNEAHYALAKLET-LGSVHSLVTQNVDALHTKAGSKNVIELHGCSHRVI 174 Query: 118 CSQS----------GQVLDWTGDVT--------------------PEDKCHCCQFPAPLR 147 C +++++ D C L+ Sbjct: 175 CLGCNQITARTALQKRMIEFNPDWHAVGQGQAPDGDTFLTSEAVKDFKVPPCKACGGILK 234 Query: 148 PHVVWFGEMPLG--MDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLE 205 P VV+FG+ ++ Y L+ +D IG++ VY + F EA G LN+ Sbjct: 235 PEVVFFGDSVPKQIVNIAYDRLAESDALWIIGSTVEVYSSYRFATEASKQGKPIAILNIG 294 Query: 206 PSQVGNEFAEKYYGPASQVVPEF 228 ++ + K G V+P+ Sbjct: 295 KTRADKLASLKVSGVCGTVLPKL 317 >UniRef50_A3LN35 NAD-dependent histone deacetylase SIR2 (Regulatory protein SIR2) (Silent information regulator 2) (Fragment) n=1 Tax=Pichia stipitis RepID=A3LN35_PICST Length = 391 Score = 195 bits (496), Expect = 1e-48, Method: Composition-based stats. Identities = 58/253 (22%), Positives = 90/253 (35%), Gaps = 30/253 (11%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEH------RVEDVATPEGFDRDPELVQAFYN 56 +++V++GAGIS GI FR+ GL+ + + V F +DP + FY+ Sbjct: 110 AKKIMVISGAGISTSLGIPDFRSFKGLYAQLEHLNLKDPQKVFDMGAFQKDPSI---FYS 166 Query: 57 ARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELL 114 + PE + + H + LQD G TQNIDNL R G +I HG Sbjct: 167 IAH-LVLPPEGRFSMLHSFIKLLQDK-GKLLRNYTQNIDNLESRVGIHPDKLIQCHGSFG 224 Query: 115 KVRCSQSGQVLDWTGDVTPEDKCHCCQF-------------PAPLRPHVVWFGEMPLG-- 159 C H + ++P + +FGE Sbjct: 225 SASCLTCSNRFAGHKIFEHIRHQHVPRCSTCWKTIQEAVIIHGVIKPDITFFGEDLPKKF 284 Query: 160 MDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYG 219 + D+ I +GTS V P + + + V +N +P +F G Sbjct: 285 YRLLEPDCQTCDLVIVVGTSLKVEPVSSIIDKIPRS-VPRVLINKDPIP-DRDFDLSLIG 342 Query: 220 PASQVVPEFVEKL 232 VV +L Sbjct: 343 LCDDVVCHLTREL 355 >UniRef50_B3S4A5 Putative uncharacterized protein n=1 Tax=Trichoplax adhaerens RepID=B3S4A5_TRIAD Length = 295 Score = 195 bits (496), Expect = 1e-48, Method: Composition-based stats. Identities = 53/260 (20%), Positives = 106/260 (40%), Gaps = 33/260 (12%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEGFDRDPELVQAFYNARR 59 ++ ++L+LTGAG+S SGI +R+ GL+ + + + D + + Sbjct: 31 LKSKKLLILTGAGVSTASGIPDYRSKGVGLYARSNQRPMQYSDFLENDENRKRYWSRNFT 90 Query: 60 RQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCS 119 + ++PN H +AKL+ L +VTQN+D LH+RAG++ + +HG + +V C Sbjct: 91 GWSRFSSVKPNLTHNFIAKLEQ-LKLLHWVVTQNVDGLHQRAGSSRLTELHGTMHEVICL 149 Query: 120 QSGQVL-------------DWTGDVTPEDKCH----------------CCQFPAPLRPHV 150 Q +++ + + C+ L+P+V Sbjct: 150 QCQKIILRREFQDILSKLNPNWTVKSIQTAPDADVFIAENEVMKFNLAKCECGGVLKPNV 209 Query: 151 VWFGEMPLGM--DEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQ 208 V+FG +E+ + AD + +G+S Y A + A +++ ++ Sbjct: 210 VFFGGSISKDINEEVRQHVDEADSILVVGSSLQTYSAYRIISRASDMRKPIGIVSIGETR 269 Query: 209 VGNEFAEKYYGPASQVVPEF 228 + + K +Q+ Sbjct: 270 ADHLASFKISINCNQLFENL 289 >UniRef50_B2ATE5 Predicted CDS Pa_1_15580 n=4 Tax=Sordariomyceta RepID=B2ATE5_PODAN Length = 404 Score = 195 bits (495), Expect = 1e-48, Method: Composition-based stats. Identities = 64/248 (25%), Positives = 92/248 (37%), Gaps = 38/248 (15%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEG------FDRDPELVQAF 54 R++V+TGAGIS +GI FR+ D GL+ D+ PE F +P + F Sbjct: 33 RAKRIVVMTGAGISTAAGIPDFRSPDTGLYANLASLDLPEPEAVFDLGFFKVNP---RPF 89 Query: 55 YNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGN--TNVIHMHGE 112 Y + L G L TQNID L AG +I HG Sbjct: 90 YVLAKEL-----------------LLAEKGLLHQLFTQNIDCLEREAGIPAEKIIEAHGS 132 Query: 113 LLKVRCSQSGQVLDWTGDVTPE-----DKCHCCQFPAPLRPHVVWFGEMPL-GMDEIYMA 166 RC + D +C ++P +V+FGE + Sbjct: 133 FASQRCIECKTEFDAGKMREFVSQGEVPRCEDGGCKGLVKPDIVFFGEQLPKAFFDRRDM 192 Query: 167 LSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPS-QVGNEFAEKY-YGPASQV 224 AD+ + +GTS V+P AG V A V NLE +G + + G + Sbjct: 193 AEEADLVLVMGTSLQVHPFAGLVDLAAER-VPRVLFNLERVGSMGCQADDVLALGDCDEG 251 Query: 225 VPEFVEKL 232 V ++L Sbjct: 252 VRRLADEL 259 >UniRef50_A5DJ74 Putative uncharacterized protein n=2 Tax=Pichia guilliermondii RepID=A5DJ74_PICGU Length = 522 Score = 195 bits (495), Expect = 1e-48, Method: Composition-based stats. Identities = 63/261 (24%), Positives = 94/261 (36%), Gaps = 38/261 (14%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEH------RVEDVATPEGFDRDPELVQAFYN 56 ++LVL+GAGIS GI FR++ G + + +DV F DP + FY+ Sbjct: 209 AKKILVLSGAGISTSLGIPDFRSSQGFYAKLEHLGLSDPQDVFDLGIFHTDPTV---FYS 265 Query: 57 ARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELL 114 + PE H + L D G TQNIDNL G + V+ HG Sbjct: 266 IAH-MILPPEHSFTPMHAFIKTLDDK-GILLRNYTQNIDNLESNVGINSDRVVQCHGSFA 323 Query: 115 KVRCSQSGQVLDWTGD---VTPEDKCHCCQF------------------PAPLRPHVVWF 153 C + + ++ +C + ++P + +F Sbjct: 324 TATCVTCKNTIPGHEIFECIRNKEVAYCTKCTNSRLALMDKDDAYVPESYGVMKPDITFF 383 Query: 154 GEMPLG--MDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGN 211 GE D I L D+ I++GTS V P A V + + +N +P N Sbjct: 384 GESLPAKFHDTINEDLHECDLVISVGTSLKVAPVADIVDKVPPS-VPQILINRDPITHCN 442 Query: 212 EFAEKYYGPASQVVPEFVEKL 232 F G V KL Sbjct: 443 -FDVSLLGYCDDVAELLERKL 462 >UniRef50_Q07FY7 Sirtuin (Silent mating type information regulation 2 homolog) 3 (S. cerevisiae) n=3 Tax=Xenopus RepID=Q07FY7_XENTR Length = 401 Score = 194 bits (494), Expect = 2e-48, Method: Composition-based stats. Identities = 61/248 (24%), Positives = 96/248 (38%), Gaps = 24/248 (9%) Query: 3 KPRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEG------FDRDPELVQAFY 55 ++V+ GAGIS SGI FR GL++ + D+ PE F +P Sbjct: 126 CTNIIVMAGAGISTASGIPDFRTPGSGLYDNLQKYDIPYPEAIFDINYFVCNPNPFF--- 182 Query: 56 NARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGN--TNVIHMHGEL 113 ++L + +PN H + L D G TQNID L AG ++ +HG Sbjct: 183 -HLAKELFPGKYKPNLVHYFIKLLHDK-GLLLRCYTQNIDGLERLAGIPVEKIVEVHGTF 240 Query: 114 LKVRCSQSGQVLDWTG--DVTPEDKCHCCQ-FPAPLRPHVVWFGEMPLG-MDEIYMALSM 169 CS ++ + CC+ P++P +V+FGE + Y Sbjct: 241 FSASCSLCYTPFPANEAKELIFDGNPPCCKFCAGPVKPDIVFFGEDLPQTFTQAYQDFPK 300 Query: 170 ADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPS-----QVGNEFAEKYYGPASQV 224 AD+ I +GTS + P A V+ K + +N E + G + Sbjct: 301 ADLLIIMGTSLKIEPFASLVNTVKPS-IPRLLINREKVGPFAKKRLRRRDVAELGDLCDI 359 Query: 225 VPEFVEKL 232 + V +L Sbjct: 360 IHTMVSRL 367 >UniRef50_D2Q1M5 Silent information regulator protein Sir2 n=7 Tax=Actinomycetales RepID=D2Q1M5_9ACTO Length = 294 Score = 194 bits (494), Expect = 2e-48, Method: Composition-based stats. Identities = 61/258 (23%), Positives = 93/258 (36%), Gaps = 38/258 (14%) Query: 9 LTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQ-PEI 67 L+GAGIS ESGI +R A G H F + ++ + Sbjct: 40 LSGAGISTESGIPDYRGASGSLRTHTPMTYGD---FVGSEAGRRRYWARSHLGWRTIARA 96 Query: 68 QPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQVLDW 127 PNA H A+A LQ G ++TQN+D LH+ AG +VI +HG L +V C + Sbjct: 97 DPNAGHRAVATLQAR-GYLTAVITQNVDGLHQSAGARDVIELHGNLDRVICLDCHETSPR 155 Query: 128 ------------------------------TGDVTPEDKCHCCQFPAP-LRPHVVWFGEM 156 V C + +P L+P VV+FGE Sbjct: 156 EDLDRRLRAANPAFEGRALRINPDGDVELPDEAVEGFRLVPCRRCGSPLLKPDVVFFGEN 215 Query: 157 P--LGMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFA 214 ++ Y + A+ + +G+S V FV A G + +N ++ Sbjct: 216 VPKPRVERCYRLIDEAEAMLVLGSSLTVMSGFRFVRYAAKAGKPVLIINQGITRGDPHAT 275 Query: 215 EKYYGPASQVVPEFVEKL 232 + P + L Sbjct: 276 HRVNLPLGHALTTLTSAL 293 >UniRef50_C5L8Y4 Chromatin regulatory protein sir2, putative n=2 Tax=Perkinsus marinus ATCC 50983 RepID=C5L8Y4_9ALVE Length = 719 Score = 194 bits (493), Expect = 2e-48, Method: Composition-based stats. Identities = 56/249 (22%), Positives = 89/249 (35%), Gaps = 40/249 (16%) Query: 4 PRVLVLTGAGISAESGIRTFRAAD-GLWEEH------RVEDVATPEGFDRDPELVQAFYN 56 R++V+ GAGIS +GI FR GL+ R ED+ + + F ++P FY+ Sbjct: 71 KRIIVMAGAGISVSAGIPDFRTPGSGLYYNLQSYKLGRPEDMFSMDFFKKNP---YPFYH 127 Query: 57 ARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELL 114 + + +P H + LQ+ G + TQNID L AG + N++ HG Sbjct: 128 FAKHLWPTGQHRPTPTHYFVRLLQEK-GLLHRMYTQNIDGLERLAGVKDENLVEAHGTFS 186 Query: 115 KVRCSQSGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDE--IYMALSMADI 172 C + V+D ++P +V+FGE + D+ Sbjct: 187 TASCIKCRSVVDPIQV-------------GLIKPDIVFFGESLPRRFHTLMQSDFETCDL 233 Query: 173 FIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGN-----------EFAEKYYGPA 221 I +GTS V P V + +N E Sbjct: 234 LIVMGTSLKVAPFNRLVSDVPDTTVRL-LVNREKQPGAGSDPMVFDGDCAYRDIWMESDC 292 Query: 222 SQVVPEFVE 230 V + V+ Sbjct: 293 DSGVEKIVD 301 >UniRef50_B3QYR0 Silent information regulator protein Sir2 n=1 Tax=Chloroherpeton thalassium ATCC 35110 RepID=B3QYR0_CHLT3 Length = 244 Score = 194 bits (493), Expect = 2e-48, Method: Composition-based stats. Identities = 90/243 (37%), Positives = 130/243 (53%), Gaps = 17/243 (6%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 K R+++ +GAG+SAES I TFR ++GLWE HR+EDVA+PEG+ R+P LV FY R ++ Sbjct: 2 KKRIVIFSGAGLSAESDIPTFRDSNGLWESHRIEDVASPEGWQRNPALVLDFYAKRYEKM 61 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSG 122 Q +PN+AH A+AKL +L + +TQNIDNL E+AG V H+HG + +C Sbjct: 62 Q--TCKPNSAHEAIAKL--SLRHEVICITQNIDNLLEQAGVETVWHLHGRIDVQKCEWHK 117 Query: 123 QVLDWTGDVTPEDKC-----------HCCQFPAPLRPHVVWFGEMPLGMDE-IYMALSMA 170 + + + D C LRP VVWFGE + + Sbjct: 118 SIPAYYDERFQCDFSGAIKRPIAFGDACPVCGGQLRPDVVWFGEAVDMRQSYLQELVRTT 177 Query: 171 DIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVE 230 DIFI +GTS VYPAAG + + ++ +P+ E G AS+ +P V+ Sbjct: 178 DIFIGVGTSAQVYPAAGLLSIFEKVRDK-YFIDPKPAYSVLSDFEVLNGSASEKMPLLVD 236 Query: 231 KLL 233 +L+ Sbjct: 237 QLI 239 >UniRef50_C7NJ50 NAD-dependent protein deacetylase, SIR2 family n=4 Tax=Actinomycetales RepID=C7NJ50_KYTSD Length = 325 Score = 194 bits (493), Expect = 3e-48, Method: Composition-based stats. Identities = 63/284 (22%), Positives = 100/284 (35%), Gaps = 47/284 (16%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 +E+ R+ V+TGAG+S SGI +R DG+ R T F PE + ++ Sbjct: 44 LERHRLAVVTGAGMSTASGIPDYRGPDGV----RRVQPMTIGDFRAGPESRRRYWARAFV 99 Query: 61 QL-QQPEIQPNAAHLALAKLQD------ALGDRFLLVTQNIDNLHERAGNTNVIHMHGEL 113 + QPNA H LA LQ A+ ++TQN+D LH+RAG+ +V+ +HG L Sbjct: 100 GWERFTGAQPNAGHRLLAALQTEGVVSGAVAGITGVITQNVDGLHQRAGSPDVLELHGTL 159 Query: 114 LKVRCSQSGQVLDWTGDVTP---------------------------------EDKCHCC 140 + C G C Sbjct: 160 SAIVCLVCGAAESRESIQARLAAANPHHRDIVLGGAQVRPDGDVALDEETVAAFRTVECL 219 Query: 141 QFP-APLRPHVVWFGEMP--LGMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGA 197 L+P VV+FGE + + Y + AD + +G+S V F G Sbjct: 220 VCGSDELKPDVVYFGENVPKPRVADAYAMVDAADGLLVLGSSLKVMSGYRFARHVHRAGG 279 Query: 198 HTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKGLKAGSI 241 + + E + + + L G++ + Sbjct: 280 PVAVVTRGWHRADREASLTIDAMVDTTLAAVADVLGVGIRPDAA 323 >UniRef50_A7RLD5 Predicted protein (Fragment) n=1 Tax=Nematostella vectensis RepID=A7RLD5_NEMVE Length = 335 Score = 194 bits (493), Expect = 3e-48, Method: Composition-based stats. Identities = 61/245 (24%), Positives = 84/245 (34%), Gaps = 27/245 (11%) Query: 9 LTGAGISAESGIRTFRAAD-GLWEEHR------VEDVATPEGFDRDPELVQAFYNARRRQ 61 + GAGIS SGI FR GL++ + + E F DP + Sbjct: 1 MAGAGISTPSGIPDFRTPGTGLYDNLQEYNIPEPTAIFDIEYFWYDPRPFFC----LAKT 56 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELLKVRCS 119 L QPN H + L D G + TQNID L AG ++ HG C Sbjct: 57 LYPGNYQPNYVHYFVKLLHDK-GFLLRMYTQNIDGLERLAGLPAEKLVEAHGTFSTASCI 115 Query: 120 QSGQVLDWTGD---VTPEDKCHCC--QFPAPLRPHVVWFGE-MPLGMDEIYMALSMADIF 173 D + D C + ++P VV+FGE +P + D+ Sbjct: 116 SCHHSYDGEQIRKTIENGDIPRCETIKCKGVIKPDVVFFGEDLPKRFYSFEIDFRKCDLL 175 Query: 174 IAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQ------VGNEFAEKYYGPASQVVPE 227 + +GTS V P AG V+E V +N E G V Sbjct: 176 LVMGTSLEVEPFAGIVNEVSRS-TPRVLINRESVGPFLHPWRRRPKDVVLKGDIVSSVKR 234 Query: 228 FVEKL 232 + L Sbjct: 235 LAKLL 239 >UniRef50_Q9ZJW8 NAD-dependent deacetylase n=58 Tax=Bacteria RepID=NPD_HELPJ Length = 234 Score = 193 bits (492), Expect = 3e-48, Method: Composition-based stats. Identities = 91/233 (39%), Positives = 129/233 (55%), Gaps = 10/233 (4%) Query: 4 PRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQ 63 +++L+GAGISAESGI+TFR A GLWE H + +VA+P G+ ++P+ V FYN RRRQL Sbjct: 2 KNLVILSGAGISAESGIKTFRDAGGLWEGHDIMEVASPYGWKKNPQKVLDFYNQRRRQLF 61 Query: 64 QPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS-G 122 E+ PN AH ALA+L+ ++TQN+D+LHERAG++ ++H+HGELL VR + Sbjct: 62 --EVYPNKAHKALAELEKHYQ--VNIITQNVDDLHERAGSSRILHLHGELLSVRSEKDPN 117 Query: 123 QVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGHV 182 V W D+ D Q A LRP +VWFGE + E + + I IGTS V Sbjct: 118 LVYRWEKDLNLGDLA---QDKAQLRPDIVWFGEEVPLLKEAVSLVKQVHLLIIIGTSLQV 174 Query: 183 YPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAE-KYYGPASQVVPEFVEKLLK 234 YPAA A A ++ + A + + + KL++ Sbjct: 175 YPAASLYTHA-NKDALIYYIDPKAKNARLPQNVQCINENAVHAMQDLMPKLIE 226 >UniRef50_Q5GUM2 SIR2-like regulatory protein n=5 Tax=cellular organisms RepID=Q5GUM2_XANOR Length = 357 Score = 193 bits (492), Expect = 3e-48, Method: Composition-based stats. Identities = 70/262 (26%), Positives = 103/262 (39%), Gaps = 41/262 (15%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 R+ VLTGAG S +SGI +R G W+ + T + F + Q ++ R Sbjct: 82 RHQRLFVLTGAGCSTDSGIPDYRDLQGGWKRPQPV---TFQAFMGELSTRQRYW--ARSL 136 Query: 62 LQQPE---IQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRC 118 + P QPNA H ALA L+ G +L+TQN+D LH+ AG+ VI +HG L VRC Sbjct: 137 VGWPRFGLAQPNATHHALAALEAR-GQLEVLLTQNVDRLHQAAGSQAVIDLHGRLDVVRC 195 Query: 119 SQSGQVLDWTG------------------------------DVTPEDKCHCCQFPAPLRP 148 + + T C L+P Sbjct: 196 MGCERRMPRTEFQLLLEQANPGWAAREAAQAPDGDADLDDVAFEHFVVPPCPVCGGVLKP 255 Query: 149 HVVWFGEMPL--GMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEP 206 VV+FGE ++ + L AD + +G+S VY FV A +G LN+ Sbjct: 256 DVVFFGENVPRERVERAFAHLQAADAVLVVGSSLMVYSGFRFVQTAARNGLPIAALNVGH 315 Query: 207 SQVGNEFAEKYYGPASQVVPEF 228 ++ K +Q + Sbjct: 316 TRADELLTLKVEQSCAQALAFL 337 >UniRef50_B0E5U4 NAD-dependent deacetylase sirtuin-2, putative n=2 Tax=Entamoeba RepID=B0E5U4_ENTDI Length = 383 Score = 193 bits (492), Expect = 3e-48, Method: Composition-based stats. Identities = 59/250 (23%), Positives = 91/250 (36%), Gaps = 19/250 (7%) Query: 4 PRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEG---FDRDPELVQAFYNARR 59 ++ L GAG+S +GI FR+ GL+ + ++ PE + P FY + Sbjct: 135 KNIIALVGAGMSTTAGIPDFRSPGTGLYFNLQKYNLPYPEAVFDMNYFPSNPAPFYEVMK 194 Query: 60 RQLQ-QPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELLKV 116 Q + P H L L D G ++ TQNID L AG N VI HG Sbjct: 195 DMFPGQGKYFPTKCHRFLKLLNDK-GILKMVYTQNIDGLESVAGIPNDKVICSHGTFRTS 253 Query: 117 RCSQSGQVLDW---TGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMAD 171 C + + + + C ++P +V+F E + I D Sbjct: 254 HCLSCHKKYPDTSVFIESIKKGEIIRCSCGGLVKPDIVFFNESLPDEFFESIKNKFDDCD 313 Query: 172 IFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQ----VGNE-FAEKYYGPASQVVP 226 + + IGT+ VYP A V ++ V +N E N G + Sbjct: 314 MLLIIGTALVVYPFANLVDHVSINC-PRVCINREKVGKMMCYDNLGRDVALLGGCDDIAS 372 Query: 227 EFVEKLLKGL 236 + + L L Sbjct: 373 DLAKYLEWEL 382 >UniRef50_A0C6J0 Chromosome undetermined scaffold_152, whole genome shotgun sequence n=1 Tax=Paramecium tetraurelia RepID=A0C6J0_PARTE Length = 449 Score = 193 bits (492), Expect = 3e-48, Method: Composition-based stats. Identities = 69/244 (28%), Positives = 104/244 (42%), Gaps = 20/244 (8%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPE------GFDRDPELVQAF 54 + RV VL GAG+S +GI FR GL+ + + ++ +PE F ++PE F Sbjct: 208 KFQRVCVLAGAGMSVAAGIPDFRTPGTGLYSQIQKYNLPSPESVFEIEYFKKNPEA---F 264 Query: 55 YNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGN--TNVIHMHGE 112 Y + L + +P AH L L D+ G TQNID L AG VI HG Sbjct: 265 YCVAKEFLLSFDAKPTLAHKFLKFL-DSRGQLLKCFTQNIDGLELDAGVSQDKVIQAHGH 323 Query: 113 LLKVRCSQSGQVL---DWTGDVTPEDKCHCCQFPA--PLRPHVVWFGEMPL-GMDEIYMA 166 + RC + + + D+ + D C + P ++P VV+FGE + Sbjct: 324 MRTARCIECQEEVSIKDFMSHIKKGDIHRCEKCPKKGLVKPDVVFFGEGLPGEFFYSWNC 383 Query: 167 LSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVP 226 L AD+ I IGTS V P A V + + +N E G + G + Sbjct: 384 LKDADLLIVIGTSLKVMPFAASVAKVGPT-TPIILINRENVLNGRKNLLHLDGDIEENCK 442 Query: 227 EFVE 230 + ++ Sbjct: 443 KLLQ 446 >UniRef50_B6H5J7 Pc14g00270 protein n=6 Tax=Trichocomaceae RepID=B6H5J7_PENCW Length = 340 Score = 193 bits (491), Expect = 4e-48, Method: Composition-based stats. Identities = 64/263 (24%), Positives = 99/263 (37%), Gaps = 28/263 (10%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEG------FDRDPELVQAF 54 + R++VLTGAGIS +GI FR+ + GL+++ + PE F PE A Sbjct: 28 KATRIVVLTGAGISTGAGIPDFRSPNTGLYDKLAPLRLPYPEAIFHVNYFSHTPEPFYAI 87 Query: 55 YNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGE 112 AR ++P H LA + TQNID L + AG V+ HG Sbjct: 88 ARARH----PGNLKPTVTHAFLAL-LAKKNLLHFVFTQNIDGLEQDAGVPPDKVLWTHGN 142 Query: 113 LLKVRCSQSGQVLD---WTGDVTPEDKCHCCQ--FPAPLRPHVVWFGEMPL-GMDEIYMA 166 C + + + +C ++P VV+FG+ DE Sbjct: 143 WKSQHCYKCKSSYPDDLMNKAIRTGEVPYCLDTGCGGAVKPDVVFFGQSLSAEFDEKEKE 202 Query: 167 LSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQ--VGNEFAEKYYGPASQV 224 + AD+ + +GTS V P + G V +N E + + G Sbjct: 203 VLEADLMLVMGTSLRVAPCSRLPRLV-RRGIPRVLINNEKAGDLGNRDDDVCILGSCDDG 261 Query: 225 VPEFVEKL-----LKGLKAGSIA 242 V + + L L L ++A Sbjct: 262 VRQLADALGWGEDLNDLWEEAVA 284 >UniRef50_Q9NRC8 NAD-dependent deacetylase sirtuin-7 n=27 Tax=Coelomata RepID=SIRT7_HUMAN Length = 400 Score = 193 bits (490), Expect = 5e-48, Method: Composition-based stats. Identities = 52/250 (20%), Positives = 91/250 (36%), Gaps = 40/250 (16%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 ++V TGAGIS + I +R +G+W + + Sbjct: 98 NAKYLVVYTGAGISTAASIPDYRGPNGVWTLLQKGRSVSAADL----------------- 140 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTN--VIHMHGELLKVRCS 119 E +P H+++ +L + +V+QN D LH R+G + +HG + C+ Sbjct: 141 ---SEAEPTLTHMSITRLHEQK-LVQHVVSQNCDGLHLRSGLPRTAISELHGNMYIEVCT 196 Query: 120 QS--GQVLDWTGD-------VTPEDKCHCCQFPAPLRPHVVWFGEM-----PLGMDEIYM 165 + D + C + LR +V FGE PL + Sbjct: 197 SCVPNREYVRVFDVTERTALHRHQTGRTCHKCGTQLRDTIVHFGERGTLGQPLNWEAATE 256 Query: 166 ALSMADIFIAIGTSGHV---YPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPAS 222 A S AD + +G+S V YP + + +NL+ + + A K +G Sbjct: 257 AASRADTILCLGSSLKVLKKYPRLWCMTKPPSRRPKLYIVNLQWTPKDDWAALKLHGKCD 316 Query: 223 QVVPEFVEKL 232 V+ + +L Sbjct: 317 DVMRLLMAEL 326 >UniRef50_B9W8S7 SIR2-family NAD-dependent histone deacetylase, putative n=4 Tax=Candida RepID=B9W8S7_CANDC Length = 611 Score = 193 bits (490), Expect = 6e-48, Method: Composition-based stats. Identities = 62/279 (22%), Positives = 97/279 (34%), Gaps = 55/279 (19%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEH------RVEDVATPEGFDRDPELVQAFY 55 ++V+TGAGIS GI FR++ G + ++V + F+ DP+L FY Sbjct: 256 NCENIMVITGAGISTSLGIPDFRSSQGFYSMVQHLGLSDPQEVFDLDIFNNDPKL---FY 312 Query: 56 NARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGEL 113 + L I + H + LQD TQNIDNL AG +I HG Sbjct: 313 SIAHMILPPNHI-FSPLHSFIKLLQDKQ-KLLRNYTQNIDNLESYAGISKEKLIQCHGSF 370 Query: 114 LKVRCSQSGQVLD---WTGDVTPEDKCHCCQFPAP------------------------- 145 C G +D ++ + +C + Sbjct: 371 ATASCITCGYQVDGEIIFPEIKNKQIPYCPKCNEIKQSILKSKKKKQRKNYDDYDDDEDE 430 Query: 146 ----------LRPHVVWFGEMPLGMDEIY--MALSMADIFIAIGTSGHVYPAAGFVHEAK 193 ++P + +FGE +I ++ D+ I IGTS V P A V + Sbjct: 431 ETYFHESFGVMKPDITFFGEQLPENFKIAINQDINKVDLVIVIGTSLKVAPVADIVGKIP 490 Query: 194 LHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 + LN +P +F G + +L Sbjct: 491 ES-VPQILLNKDPINHC-QFDVSLLGYCDDIASYIANEL 527 >UniRef50_B2AR57 Predicted CDS Pa_4_8570 n=1 Tax=Podospora anserina RepID=B2AR57_PODAN Length = 588 Score = 193 bits (490), Expect = 6e-48, Method: Composition-based stats. Identities = 66/297 (22%), Positives = 103/297 (34%), Gaps = 64/297 (21%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAAD-GLWEEH------RVEDVATPEGFDRDPELVQAF 54 EK ++VLTGAGIS GI FR+A GL+ + ++V F +DP + F Sbjct: 234 EKKNIIVLTGAGISTSLGIPDFRSAGTGLYSKLAHLGLNDPQEVFDLSVFRQDPTI---F 290 Query: 55 YNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGE 112 Y+ + L E + H + LQ+ G TQNIDNL +AG ++ HG Sbjct: 291 YSVAKDIL-PSEDRYTPTHQFIRMLQER-GKLLTNYTQNIDNLESKAGILPEKLVQCHGS 348 Query: 113 LLKVRCSQSGQVL---DWTGDVTPEDKCHCCQFPA------------------------- 144 C + G+ + ++ C + P+ Sbjct: 349 FATASCVKCGEKVVGDSIFAEIKAGKIPRCRKCPSGQSRSQSRKRKTANSSNSKRRRDFD 408 Query: 145 -----------------PLRPHVVWFGEMPLGMDE---IYMALSMADIFIAIGTSGHVYP 184 ++P +++FGE + D+ I IGTS V P Sbjct: 409 RDSNSDSEFDLVSSSAGVMKPDIIFFGEPLPDEFSQRLTQHDVDRVDLVIVIGTSLKVAP 468 Query: 185 AAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKLLKGLKAGSI 241 + V H + ++ E N F G VV E + L + Sbjct: 469 VSEVVPYLPSH-IPQIYISREAIGHNN-FDIDLLGDCDVVVAELCRRAGWELGHEMV 523 >UniRef50_A8I1B6 NADH-dependent histone deacetylase (Fragment) n=1 Tax=Chlamydomonas reinhardtii RepID=A8I1B6_CHLRE Length = 269 Score = 192 bits (489), Expect = 6e-48, Method: Composition-based stats. Identities = 51/241 (21%), Positives = 86/241 (35%), Gaps = 29/241 (12%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 + RV V TGAGIS GI FR +G+W + + P F Sbjct: 44 DAKRVFVFTGAGISTACGIPDFRGPNGIWTLRKKGE--------ALPTDFTPF------- 88 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELLKVRCS 119 +P+ H+A++ L A G + +QN+D+LH +G + + +HG RC Sbjct: 89 ---EYARPSFTHMAISGLV-AAGKCPYVCSQNVDSLHLWSGVPRSRIAELHGNCFAERCR 144 Query: 120 QSGQVLDWTGDVTPED------KCHCCQFPAPLRPHVVWFGEMPL--GMDEIYMALSMAD 171 G + D +C L +++ + +DE AD Sbjct: 145 GCGAEYARDFQMETVDFRPSGRRCTAPGCGGELVDNILDWDTPLPQDELDEAVRQAEEAD 204 Query: 172 IFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEK 231 + + +GTS + PA + G V +NL+ + + + Sbjct: 205 VALVLGTSLQIQPANEIPVLTRDEGGKLVIVNLQKTPKDRRANLLLRARVDLAMALLARE 264 Query: 232 L 232 L Sbjct: 265 L 265 >UniRef50_A5DNV7 Putative uncharacterized protein n=2 Tax=Pichia guilliermondii RepID=A5DNV7_PICGU Length = 403 Score = 192 bits (489), Expect = 6e-48, Method: Composition-based stats. Identities = 61/258 (23%), Positives = 98/258 (37%), Gaps = 32/258 (12%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEH------RVEDVATPEGFDRDPELVQAFY 55 + ++LV+TGAGIS GI FR+ G++ + + V + F +DP L FY Sbjct: 115 KAKKILVVTGAGISTSLGIPDFRSFQGIYSQLSRSGLENAQQVFHIDRFCKDPTL---FY 171 Query: 56 NARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGEL 113 + + L Q + + + H L L+ + TQNIDNL AG + ++H HG L Sbjct: 172 SVAHKILPQGD-KVSDFHRFLRLLEQK-NKLLRVYTQNIDNLELAAGIDPSRIVHCHGTL 229 Query: 114 LKVRCSQSGQVLD---WTGDVTPEDKCHCCQF---------PAPLRPHVVWFGEMPLGMD 161 C + +C ++P + +FGE Sbjct: 230 STSTCLTCRATFSGAATFAAIKMRQVPYCSLCVTDLGSVPMKGLIKPDITFFGEDLSSRF 289 Query: 162 E--IYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYG 219 E I + D+ + GTS V P A V A V +N + F + G Sbjct: 290 ETMIGKDVEECDLLLVAGTSLKVEPVASIVRNA--QNVKKVLVNRDKIDG---FDINFLG 344 Query: 220 PASQVVPEFVEKLLKGLK 237 + ++L L+ Sbjct: 345 NCDDISGYICQELKWKLE 362 >UniRef50_Q8R104 NAD-dependent deacetylase sirtuin-3 n=14 Tax=Deuterostomia RepID=SIRT3_MOUSE Length = 257 Score = 192 bits (489), Expect = 7e-48, Method: Composition-based stats. Identities = 59/241 (24%), Positives = 90/241 (37%), Gaps = 23/241 (9%) Query: 9 LTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEG------FDRDPELVQAFYNARRRQ 61 + GAGIS SGI FR+ GL+ + D+ PE F +P+ ++ Sbjct: 1 MVGAGISTPSGIPDFRSPGSGLYSNLQQYDIPYPEAIFELGFFFHNPKPFF----MLAKE 56 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGN--TNVIHMHGELLKVRCS 119 L +PN H L L D L TQNID L +G + ++ HG + C+ Sbjct: 57 LYPGHYRPNVTHYFLRLLHDKE-LLLRLYTQNIDGLERASGIPASKLVEAHGTFVTATCT 115 Query: 120 QSGQVL---DWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPL-GMDEIYMALSMADIFIA 175 + D DV + C ++P +V+FGE ++AD+ + Sbjct: 116 VCRRSFPGEDIWADVMADRVPRCPVCTGVVKPDIVFFGEQLPARFLLHMADFALADLLLI 175 Query: 176 IGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQ----VGNEFAEKYYGPASQVVPEFVEK 231 +GTS V P A EA + +N + G V V+ Sbjct: 176 LGTSLEVEPFASL-SEAVQKSVPRLLINRDLVGPFVLSPRRKDVVQLGDVVHGVERLVDL 234 Query: 232 L 232 L Sbjct: 235 L 235 >UniRef50_Q8FUC8 NAD-dependent deacetylase 1 n=11 Tax=Corynebacterium RepID=NPD1_COREF Length = 281 Score = 192 bits (489), Expect = 8e-48, Method: Composition-based stats. Identities = 66/270 (24%), Positives = 104/270 (38%), Gaps = 42/270 (15%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 +E VL +TGAG+S +SGI +R+ G + R T + F DP ++ Sbjct: 14 LEAGSVLAVTGAGVSTDSGIPDYRSPRGSLNQGRPM---TYQEFRFDPVASHRYWARSFV 70 Query: 61 QLQ-QPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCS 119 + + QPN H AL +L+ A G +VTQN+D LH RAG+ N++ +HG+L + C Sbjct: 71 GWRVMADAQPNRTHYALVELERA-GLLSGIVTQNVDGLHRRAGSENLVALHGDLATIVCL 129 Query: 120 QSGQVLDW----------------------------------TGDVTPEDKCHCCQFPAP 145 Q G V C + + Sbjct: 130 QCGHREARELLDARLDHLNPGYFDSIALDPSAVNPDGDVTLDDHHVQRFTMAGCARCGSV 189 Query: 146 -LRPHVVWFGEMPLGM--DEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVEL 202 L+P VV+FGE + + L AD + G+S V V EA+ G + Sbjct: 190 LLKPDVVYFGEPVPSIRKTRVAQLLDGADAVVVAGSSLAVMSGYRIVIEAQRAGKPVAVI 249 Query: 203 NLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 N P + + + + ++ L Sbjct: 250 NGGPGRADHRVDILWRTRVGPAFDQILDAL 279 >UniRef50_D2VCI1 Silent information regulator family protein n=2 Tax=Naegleria gruberi RepID=D2VCI1_NAEGR Length = 452 Score = 192 bits (488), Expect = 8e-48, Method: Composition-based stats. Identities = 53/242 (21%), Positives = 96/242 (39%), Gaps = 30/242 (12%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 + +++ TGAGIS +GIR +R+ +G+W ++ Sbjct: 102 QSKHIVLYTGAGISRAAGIRDYRSPNGVWTMKEKGV------------------KTVAKK 143 Query: 62 LQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELLKVRCS 119 + I P H+A++ L +A G + +QN+D LH ++G N+ +HG C Sbjct: 144 DESKIIFPTRTHMAISTLYNA-GKIQYVTSQNVDGLHVKSGIPRKNMSELHGNTNVEICH 202 Query: 120 QSGQVLDWTGDVTPEDKCH-------CCQFPAPLRPHVVWFGEMPL--GMDEIYMALSMA 170 + H C + + L ++ F E ++ S A Sbjct: 203 KCNIEYVRNFRCRNNKNVHDHRTGRFCEKCKSELEDTIINFNENLPTDQLERAEENASKA 262 Query: 171 DIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVE 230 D+ I +GTS V PA K +G V +NL+ + + + + A +V+ ++ Sbjct: 263 DLAIVVGTSMRVNPACSLPQMCKENGGKLVIINLQLTPKDKKADLRIFAEADKVIDTVMK 322 Query: 231 KL 232 KL Sbjct: 323 KL 324 >UniRef50_A1U4N6 Silent information regulator protein Sir2 n=2 Tax=Marinobacter RepID=A1U4N6_MARAV Length = 298 Score = 192 bits (488), Expect = 9e-48, Method: Composition-based stats. Identities = 63/265 (23%), Positives = 103/265 (38%), Gaps = 40/265 (15%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQ 61 + PR+++LTGAG+S +SGI +R DG W+ + + F D Q ++ R Sbjct: 40 QHPRLMILTGAGVSTDSGIPDYRDGDGAWKRKQPVQ---HKAFMEDFHTRQRYW--ARSL 94 Query: 62 LQQP---EIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRC 118 + P PN +H ++ L+ L L+VTQN+D LH++AG V +HG +V C Sbjct: 95 IGWPVMRNAAPNPSHHYISDLE-LLNHSSLVVTQNVDRLHQKAGTRAVTDLHGRADEVVC 153 Query: 119 SQSGQVLDWTG-----------------------------DVTPEDKCHCCQFPAPLRPH 149 G D + C + L+P Sbjct: 154 MGCGYRCPRDEVHDRCAELNPGFRKYTAETAPDGDADLDVDFSEFRPVDCPRCAGILKPD 213 Query: 150 VVWFGEMPL--GMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPS 207 VV+FG+ + L +D + IG+S VY F A LNL + Sbjct: 214 VVFFGDYVPKDRVYSALDVLKASDGLLVIGSSLMVYSGFRFCRYASEWKKPIATLNLGRT 273 Query: 208 QVGNEFAEKYYGPASQVVPEFVEKL 232 + + K + + +++L Sbjct: 274 RAEDLVDLKLNARIGETLKASLDQL 298 >UniRef50_Q5KDE0 NAD-dependent histone deacetylase, putative n=2 Tax=Filobasidiella neoformans RepID=Q5KDE0_CRYNE Length = 413 Score = 192 bits (488), Expect = 9e-48, Method: Composition-based stats. Identities = 62/277 (22%), Positives = 95/277 (34%), Gaps = 52/277 (18%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAA-DGLWEEHRVEDVATPEG------FDRDPELVQAF 54 V+ L GAGIS +GI FR+ GL+ + ++ PE F R PE Sbjct: 71 NAKDVIFLLGAGISTSAGIPDFRSPSTGLYHNLQALELPFPEAVFELGFFQRRPEPFWT- 129 Query: 55 YNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTN--VIHMHGE 112 +++ P H L +L + + TQNID L AG ++ HG Sbjct: 130 ---LAKEIYPGRHFPTPTHY-LLQLFNRHNLLKRVFTQNIDTLETLAGLPPHLIVEAHGS 185 Query: 113 LLKVRCSQSGQVLDWTGD----VTPEDKCHCC----------QFPAPLRPHVVWFGE-MP 157 C + + +D V + C + ++P +V+FGE +P Sbjct: 186 FATAHCLKCRREVDREEVLKAGVRKGEVVRCDATLKAMGKGKKCGGLVKPDIVFFGEGLP 245 Query: 158 LGMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLE------------ 205 ++ L D+ I IGTS V P A V + +N E Sbjct: 246 DRFFKLVPELRKCDLLIVIGTSLQVQPFASLVDYVPSTC-PRLLINREAVGPFSDLESTF 304 Query: 206 ---PSQVGNE-------FAEKYYGPASQVVPEFVEKL 232 P + Y G A + E+L Sbjct: 305 SSLPPSISKLLNGPSPSRDMFYEGDADLGAWKLAEEL 341 >UniRef50_D1B334 Silent information regulator protein Sir2 n=2 Tax=Campylobacterales RepID=D1B334_SULD5 Length = 230 Score = 192 bits (488), Expect = 1e-47, Method: Composition-based stats. Identities = 88/235 (37%), Positives = 126/235 (53%), Gaps = 9/235 (3%) Query: 5 RVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQQ 64 +V++ +GAGISAESG+ TFR ADGLWE++R+E++ + E AFY+ARR QL Sbjct: 3 KVVIFSGAGISAESGLSTFRDADGLWEKYRIEEICQAGCLSWNRENTLAFYDARREQLTS 62 Query: 65 PEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQV 124 ++PN AH ALAKLQ+ + ++TQN+D+L ERAG +V+H+HG L ++RC Q G Sbjct: 63 --VKPNTAHYALAKLQECYPNDIDIITQNVDDLFERAGCKDVLHLHGFLPRLRCEQCGAT 120 Query: 125 LDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIAIGTSGHVYP 184 G E C RP +V+FGE + +Y A+ + IG+SG+V Sbjct: 121 -QIIGYAKQERTFTCKNCGGSFRPDIVFFGEAAPMYEHLYEAMEDCQFLVIIGSSGNVIA 179 Query: 185 AAGFVHEAKLHGAHTVELNLEPSQVGNEFAE--KYYGPASQVVPEFVEKLLKGLK 237 F K + NLE S NE Y A++ V E V + + L Sbjct: 180 MDHFALHVKHS----ILNNLEKSDAINERVYTKVLYKKATEAVDEIVGDVERFLG 230 >UniRef50_A1ZPG8 NAD-dependent deacetylase n=1 Tax=Microscilla marina ATCC 23134 RepID=A1ZPG8_9SPHI Length = 278 Score = 192 bits (488), Expect = 1e-47, Method: Composition-based stats. Identities = 75/263 (28%), Positives = 118/263 (44%), Gaps = 31/263 (11%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLW----EEHRVEDVATPEGFDRDPELVQAFYNA 57 + + LTGAGISAESG+ T+R DG+W ++ E+ AT F +P V F Sbjct: 18 QDKLITFLTGAGISAESGVPTYRGTDGIWVEGSRNYKPEEFATLRFFKENPAEVWKFVLY 77 Query: 58 RRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNT--NVIHMHGELLK 115 R+ + ++QPNA HLALA + L + F L+TQNID LH +AGNT V+ +HG + Sbjct: 78 RK--VSFRDLQPNAGHLALASTEVLLPNNFRLITQNIDRLHIKAGNTQAKVLEIHGNMET 135 Query: 116 VRCSQSG-------------QVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLG--- 159 VRCS+ D ++ C + +RP+V+ F E Sbjct: 136 VRCSEECSMDVYPFPLDIGTAPYDAKMITQQWEQLKCPDCGSLMRPNVLMFDEYYNERLY 195 Query: 160 -MDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFA---- 214 + A + +GTSG A G+ V++N+ S + Sbjct: 196 KQESAIEAALNTGVLFVVGTSGATNLPHHIASTATYRGSSLVDINIADSAFTDMATSEPD 255 Query: 215 -EKYYGPASQVVPEFVEKLLKGL 236 G + ++P+ ++L++ L Sbjct: 256 KLVLRGTSGDILPQI-KQLIQAL 277 >UniRef50_C8VEG1 SIR2 family histone deacetylase, putative (AFU_orthologue; AFUA_3G00520) n=2 Tax=Emericella nidulans RepID=C8VEG1_EMENI Length = 2081 Score = 192 bits (487), Expect = 1e-47, Method: Composition-based stats. Identities = 64/255 (25%), Positives = 93/255 (36%), Gaps = 24/255 (9%) Query: 5 RVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEG------FDRDPELVQAFYNA 57 R++ L GAG+S SG+ FR D GL+ + + PE F PE FY Sbjct: 1764 RIVALVGAGLSTSSGLADFRTPDTGLYAKLEPLQLPYPEALFHISYFKHTPEP---FYAI 1820 Query: 58 RRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELLK 115 R + +P H LA L+ G + TQNID L AG V+++HG+ Sbjct: 1821 ARGRHPWNT-KPGVGHAFLALLEKK-GVLGFVFTQNIDGLELDAGVSRERVMNLHGDWSD 1878 Query: 116 VRCSQSGQVLD---WTGDVTPEDKCHC--CQFPAPLRPHVVWFGEMPLGMDEI--YMALS 168 C + + + C ++P +V FGE + LS Sbjct: 1879 QHCIKCRSSYPADRMRKAILTGEVPFCVQANCEGIVKPAIVMFGESLPEGFDSREEEMLS 1938 Query: 169 MADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQ--VGNEFAEKYYGPASQVVP 226 AD+ + IGTS V P + H V +N E E G + Sbjct: 1939 TADLLLVIGTSLKVAPCSEIPRRLPSH-VPRVLVNRELVGNIGTRESDVCLLGDCDAWLR 1997 Query: 227 EFVEKLLKGLKAGSI 241 E L + S+ Sbjct: 1998 EVARHLGWDEELESV 2012 >UniRef50_D1Y076 Transcriptional regulator, Sir2 family n=1 Tax=Prevotella bivia JCVIHMP010 RepID=D1Y076_9BACT Length = 248 Score = 192 bits (487), Expect = 1e-47, Method: Composition-based stats. Identities = 84/244 (34%), Positives = 125/244 (51%), Gaps = 21/244 (8%) Query: 4 PRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQLQ 63 +++V TGAGIS ESG+ TFR DGLW+ + +ATPEGF D E V FYN R+ L Sbjct: 17 QKIVVFTGAGISKESGMETFRDLDGLWKRYDPAQIATPEGFAADTEFVLNFYNEMRKMLI 76 Query: 64 QPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQSGQ 123 +I+PN AH +A L++ ++TQNID+LHERAG+++VIH+HGEL KV Sbjct: 77 --DIEPNHAHKIVAALEEW--HDVTVITQNIDDLHERAGSSHVIHVHGELTKVT-----S 127 Query: 124 VLDWTGDVTPEDKCHCCQ--------FPAPLRPHVVWFGEMPLGMDEIYMALSMADIFIA 175 D+ + + LRP++VWFGE + + AD + Sbjct: 128 SYDYLNPRYIQPYPLDKAIKVGDKALDGSQLRPYIVWFGESLPDLGACVQRMQQADYLLI 187 Query: 176 IGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAE-KYYGPASQVVPEFVEKLLK 234 IGTS V PAAG ++ A + +P+ + PA++ + F+++L Sbjct: 188 IGTSLTVMPAAGLINYAPFNIPKFCI---DPNNLMLPSNIEHIKEPATRGIDIFIKRLQA 244 Query: 235 GLKA 238 + Sbjct: 245 LQQK 248 >UniRef50_D2NR35 NAD-dependent protein deacetylase n=2 Tax=Rothia mucilaginosa RepID=D2NR35_9MICC Length = 326 Score = 192 bits (487), Expect = 1e-47, Method: Composition-based stats. Identities = 64/270 (23%), Positives = 108/270 (40%), Gaps = 42/270 (15%) Query: 1 MEKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 ++ +VLVLTGAG+S ESGI +R G +HR T + F D Q ++ Sbjct: 59 LKAGKVLVLTGAGVSTESGIPDYRGPGGSLHDHRPM---TYQEFRYDDAARQRYWARSYV 115 Query: 61 QLQQ-PEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCS 119 ++ +PN AH ALA+L+ LG ++TQN+D LH RAG++ ++ +HG+L ++ C Sbjct: 116 GWRRMRRAEPNRAHYALAELEQ-LGAVSGVITQNVDGLHARAGSSRLLALHGDLSRIVCL 174 Query: 120 QSGQVLDW----------------------------------TGDVTPEDKCHCCQFP-A 144 GQ + C Sbjct: 175 DCGQDESRESLDTRLDAANLGYLARLEDEELRVNPDGDVELDDRYIRDFQMVPCLGCGST 234 Query: 145 PLRPHVVWFGEMPLGMDEIYMA--LSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVEL 202 L+P VV+FGE + L+ + +G+S V + V EA G + Sbjct: 235 RLKPDVVYFGESVPAERKALKDAMLAECSALLVVGSSVAVMSSYKIVLEALRAGKPVAVI 294 Query: 203 NLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 N P + + + + + ++++ Sbjct: 295 NGGPGRADAKATYLWRTGVGEALELMLDEI 324 >UniRef50_C1BMY9 NAD-dependent deacetylase sirtuin-2 n=3 Tax=Caligidae RepID=C1BMY9_9MAXI Length = 305 Score = 192 bits (487), Expect = 1e-47, Method: Composition-based stats. Identities = 60/274 (21%), Positives = 98/274 (35%), Gaps = 42/274 (15%) Query: 4 PRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEG------FDRDPELVQAFYN 56 +++L+GAGIS +GI FR+ GL+ + + ++ PE F +DP FY+ Sbjct: 32 KNIVILSGAGISTNAGIPDFRSPSLGLYFKLKKYNLPYPEAVFEGSYFRKDP---LPFYS 88 Query: 57 ARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELL 114 R + ++P H L+ + TQNID L AG + ++ HG Sbjct: 89 LVRE-IYPSRLEPTLTHKFLSL-LSKKKLLRRVFTQNIDGLEGLAGIPSEEIVEAHGSFA 146 Query: 115 KVRCSQSGQVLD--------WTGDVTPEDKCHCCQFPAPLRPHVVWFGE-MPLGM-DEIY 164 + C+ + + + + C +RP VV FGE MP Sbjct: 147 RSYCTSCKREYELTWLKREIFAAQESNGGVPKCESCSGIVRPDVVLFGESMPPRFSQLAE 206 Query: 165 MALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPS----------------- 207 L AD+ + IGTS V P G V G V ++ Sbjct: 207 SELKKADLLLVIGTSLAVAPFNGLVGLT-QSGTPRVYISKTRPGQSNSLLGKVLGLNSSI 265 Query: 208 QVGNEFAEKYYGPASQVVPEFVEKLLKGLKAGSI 241 + + VV + +L + + Sbjct: 266 RFEEDTDLVLLDDCDAVVLQICRQLGWEKELRDV 299 >UniRef50_C1BNZ8 NAD-dependent deacetylase sirtuin-2 n=3 Tax=Caligidae RepID=C1BNZ8_9MAXI Length = 357 Score = 191 bits (486), Expect = 1e-47, Method: Composition-based stats. Identities = 56/270 (20%), Positives = 91/270 (33%), Gaps = 44/270 (16%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAAD-GLWEEH--------RVEDVATPEGFDRDPELVQ 52 + +++ + GAGIS +GI FR D GL+ D+ + F +P+ Sbjct: 80 KARKIITMVGAGISTSAGIPDFRTPDSGLYARIAEEYPDVGNPTDLFSMNYFRMNPKP-- 137 Query: 53 AFYNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMH 110 F+ + L+ +P H + L+ G TQNID L +AG + ++ H Sbjct: 138 -FFKLAKDLLKSQSFRPTPCHYFIKLLESK-GLLLRHYTQNIDTLERKAGVNSDLLVEAH 195 Query: 111 GELLKVRCSQSGQVLD---WTGDVTPEDKCHC--CQFPAPLRPHVVWFGEMPLGMDE--I 163 G C G D V D C ++P +V+FGE + Sbjct: 196 GSFASSTCLSCGLRYDQAWMEKKVHEMDVVTCERPDCHGIVKPDIVFFGESLPERFSGLV 255 Query: 164 YMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYY----- 218 + D+ I +GTS V P A V++ + +N+E Sbjct: 256 FQDFPFCDLLIIMGTSLQVQPFASLVNQVPET-TPRLLINMEVVGNEGGNDFILRLMGRG 314 Query: 219 ----------------GPASQVVPEFVEKL 232 G + E L Sbjct: 315 GMDFSSERRYRDVAEIGSCDAGCSKLAEAL 344 >UniRef50_UPI00006CB0CC transcriptional regulator, Sir2 family protein n=1 Tax=Tetrahymena thermophila RepID=UPI00006CB0CC Length = 442 Score = 191 bits (486), Expect = 2e-47, Method: Composition-based stats. Identities = 56/248 (22%), Positives = 96/248 (38%), Gaps = 26/248 (10%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRR- 60 + ++LTGAG+S SGI +R+ + E + F + + Sbjct: 67 KSKNAVILTGAGVSTASGIPDYRSGANTILKTGPGKW-------ELEENKKKFLEEKGKP 119 Query: 61 -QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTN--VIHMHGELLKVR 117 + P+ H+A++KL ++TQN+DNLH ++G + +HG ++ R Sbjct: 120 QIILAINAFPSPTHMAISKLY-KENLIKSVITQNVDNLHHQSGIPRKDIHELHGNIISER 178 Query: 118 CSQSGQVLD-----------WTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIY 164 C + V W C L +V+FGE L Sbjct: 179 CEKCNYVHYRDFYTRLKHLKWGDPHNTGRICQKNGCDGQLHDTLVFFGESVLQNIKQSAQ 238 Query: 165 MALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQV 224 + AD+ I +GTS V AA V ++ G V +NL+ + ++ K G + Sbjct: 239 EQIESADLCIVVGTSLTVQSAARLVWISQQRGIPIVIINLQKTSYDSKA-LKINGLCEPI 297 Query: 225 VPEFVEKL 232 ++KL Sbjct: 298 FDLILKKL 305 >UniRef50_Q71W25 NAD-dependent deacetylase n=32 Tax=Bacilli RepID=NPD_LISMF Length = 229 Score = 191 bits (486), Expect = 2e-47, Method: Composition-based stats. Identities = 61/230 (26%), Positives = 101/230 (43%), Gaps = 13/230 (5%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAADGLWEEHR-VEDVATPEGFDRDPELVQAFYNARRR 60 + ++ LTGAG+S SGI +R+ +GL+ E + + R+PE FY Sbjct: 10 KAEHIVFLTGAGVSVPSGIPDYRSKNGLYAGMSSPEYMLSHTCLVREPE---KFYQFVTE 66 Query: 61 QLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQ 120 + P+ +PNA H +A+++ ++TQNID LHE+AG+ V++ HG L C + Sbjct: 67 NMYYPDAEPNAIHTKMAEIEAE--KDVTIITQNIDGLHEKAGSKKVVNFHGSLYHCYCQK 124 Query: 121 SGQVLDWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMADIFIAIGT 178 G + + + +RP VV + E +D+ A+ AD+ + +GT Sbjct: 125 CGMSVTAEEYLKSDIHS---GCGGVIRPDVVLYEEAIPESAIDQSLAAIRQADLIVIVGT 181 Query: 179 SGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEF 228 S V P + A +N E + F A +V E Sbjct: 182 SFRVSPFCNLTDY-RNKKARIFAVNKEQISLPYPFEM-MESDAVKVFAEI 229 >UniRef50_B7QJK7 Chromatin regulatory protein sir2, putative n=1 Tax=Ixodes scapularis RepID=B7QJK7_IXOSC Length = 363 Score = 191 bits (485), Expect = 2e-47, Method: Composition-based stats. Identities = 51/245 (20%), Positives = 93/245 (37%), Gaps = 35/245 (14%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 V+V+TGAGIS +GI FR +G+W + + T + Sbjct: 44 SKHVVVITGAGISTSAGIPDFRGPNGVWTLEQKGEKPTL-------------------NI 84 Query: 63 QQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGN--TNVIHMHGELLKVRCSQ 120 + P H+AL L + LV+QN+D LH ++G + +HG + RC+Q Sbjct: 85 SFDDAVPTPTHMALVALAERA-KLQFLVSQNVDGLHLKSGFPLDTLADLHGNMFVDRCNQ 143 Query: 121 SGQVLDWT------GDVTPEDKCHCCQ-----FPAPLRPHVV-WFGEMPLG-MDEIYMAL 167 + G + C + L ++ W E+P ++ Sbjct: 144 CRRQFIRDTATRTVGQKPTGEPCPVPKRNGRLCRGRLHDSILDWEDELPEDAIEAADAHC 203 Query: 168 SMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPE 227 +AD+ + +G++ + P AK + NL+P+++ V+ + Sbjct: 204 RVADLVLCLGSTLQIVPCGTLPLLAKKSAGKIIVCNLQPTKLDKSANLILRAYVDDVMTK 263 Query: 228 FVEKL 232 + KL Sbjct: 264 LMAKL 268 >UniRef50_A1HU63 Silent information regulator protein Sir2 n=1 Tax=Thermosinus carboxydivorans Nor1 RepID=A1HU63_9FIRM Length = 243 Score = 190 bits (484), Expect = 2e-47, Method: Composition-based stats. Identities = 67/237 (28%), Positives = 93/237 (39%), Gaps = 18/237 (7%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEHRVEDVATPEGFDRDPELVQAFYNARRRQL 62 VLTGAGIS SGI FR + + + T R P Y R + Sbjct: 17 ANHATVLTGAGISTASGIPDFRGINRINADLSQ---LTSTFMRRQPA---KAYELLRPFI 70 Query: 63 QQ-PEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVRCSQS 121 Q PNAAH+ LA+L G L+TQNID LH RAG V +HG L + C + Sbjct: 71 QTILAASPNAAHIGLARLLAK-GVLRGLMTQNIDGLHSRAGAGVVWELHGNLYRGYCMEC 129 Query: 122 GQVLDWTGDVTPE----DKCHCCQFPAPLRPHVVWFGEMPLG--MDEIYMALSMADIFIA 175 D G + A LRP VV+FG+ S +D+ + Sbjct: 130 RTEYDMNGPLAAFLQRGQIPTSACCGAVLRPDVVFFGDKLPAETWRHAERLASASDLMLV 189 Query: 176 IGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYGPASQVVPEFVEKL 232 IG++ V PA ++ +NL P+ + ++ K A + L Sbjct: 190 IGSTLEVAPACYLPELSRE----IAIINLGPTAMDHKATLKIECDAITACEYMLRHL 242 >UniRef50_Q2KEK3 Putative uncharacterized protein n=2 Tax=Magnaporthe grisea RepID=Q2KEK3_MAGGR Length = 525 Score = 190 bits (484), Expect = 3e-47, Method: Composition-based stats. Identities = 64/256 (25%), Positives = 89/256 (34%), Gaps = 35/256 (13%) Query: 6 VLVLTGAGISAESGIRTFRAAD-GLWEEH------RVEDVATPEGFDRDPELVQAFYNAR 58 +++L GAGIS +GI FR+ GL++ DV F +P Q FY+ Sbjct: 29 IIILAGAGISTSAGIPDFRSPKTGLYDNLARFSLDSPTDVFDINFFRTNP---QPFYSLA 85 Query: 59 RRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAG--NTNVIHMHGELLKV 116 +L P +H +A L G +L TQNID L + AG V+ HG Sbjct: 86 -PELYPGRYAPTISHAFVALLARK-GLLAMLFTQNIDGLEKAAGVPPDLVVEAHGSFDSQ 143 Query: 117 RCSQSGQVL---DWTGDVTPEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMALSMADI- 172 RC Q D V HC + ++P +V+FGE + D+ Sbjct: 144 RCIDCAQEFPAADMRAHVATSSVPHCGKCGGLVKPDIVFFGEQLPDRFFRAREAHLPDLE 203 Query: 173 --------------FIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQ--VGNEFAEK 216 I +GTS V P A G + N E Sbjct: 204 GAPIPEILGGARQVVIVMGTSLSVPPFCELPVRAAD-GVPRLLFNREVVGDFGERAQDVV 262 Query: 217 YYGPASQVVPEFVEKL 232 G V + E L Sbjct: 263 ELGDCDSGVRKLAEML 278 >UniRef50_Q6C219 YALI0F11583p n=1 Tax=Yarrowia lipolytica RepID=Q6C219_YARLI Length = 320 Score = 190 bits (484), Expect = 3e-47, Method: Composition-based stats. Identities = 67/251 (26%), Positives = 96/251 (38%), Gaps = 29/251 (11%) Query: 3 KPRVLVLTGAGISAESGIRTFRAADGLWEEH--------RVEDVATPEGFDRDPELVQAF 54 ++VL GAGIS GI FR+ADGL++ ++V E FD+DP F Sbjct: 60 AQNIVVLCGAGISTSLGIPDFRSADGLYKSLDLESLGLSDPQEVFDLEVFDQDPT---PF 116 Query: 55 YNARRRQLQQPEIQPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNT--NVIHMHGE 112 Y + + + + H L LQD G + TQNID+L AG ++ HG Sbjct: 117 YRVASKVMMPTQALISPTHAFLKLLQDK-GKLLRIYTQNIDDLEHIAGIEESKMVQCHGA 175 Query: 113 LLKVRCSQSGQVLDWTGDVT-----PEDKCHCCQFPAPLRPHVVWFGEMPLGMDEIYMAL 167 C Q G + C + ++P +V+FGE + Sbjct: 176 FHMATCRQCGAKVTCESLRPEIVAGEIPMCRRKRCEGVIKPDIVFFGEALPDRFRHMVRS 235 Query: 168 S--------MADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLEPSQVGNEFAEKYYG 219 D+F+ +GTS V PA + L G V +N EPS F G Sbjct: 236 DIIMGGPTPKVDLFLCLGTSLKVSPACDIAKQVPL-GVPRVYINREPS-ARFYFDISLCG 293 Query: 220 PASQVVPEFVE 230 + V E Sbjct: 294 ESDLAVQAICE 304 >UniRef50_Q1RPU9 Zinc finger protein (Fragment) n=2 Tax=Ciona intestinalis RepID=Q1RPU9_CIOIN Length = 320 Score = 190 bits (484), Expect = 3e-47, Method: Composition-based stats. Identities = 57/263 (21%), Positives = 105/263 (39%), Gaps = 40/263 (15%) Query: 2 EKPRVLVLTGAGISAESGIRTFRAAD-GLWEEHRVEDVATPEGFDRDPELVQAFYNARRR 60 ++ ++ VL+GAG+S ESGI +R+ D GL+ + F + + + ++ R Sbjct: 61 KRRKLFVLSGAGLSTESGIPDYRSKDVGLYARTN-HKPMQHQDFVKSADKRKIYW--ARS 117 Query: 61 QLQQPEI---QPNAAHLALAKLQDALGDRFLLVTQNIDNLHERAGNTNVIHMHGELLKVR 117 L + +PNAAH+ LA ++ G TQN+D L +AG + +HG++ +V Sbjct: 118 YLGWAKYNAWKPNAAHVKLAAME-KDGRVDWHTTQNVDGLMVKAGAEQLTELHGQMRRVV 176 Query: 118 CSQSG------------------------------QVLDWTGDVTPEDKCHCCQFPAPLR 147 C + V DV + C + L+ Sbjct: 177 CMRCNGLLDRNVMQKDMDELNKHWSAEVLGYGPDADVFICEEDVIDFNVPACRKCGGDLK 236 Query: 148 PHVVWFGEMPL--GMDEIYMALSMADIFIAIGTSGHVYPAAGFVHEAKLHGAHTVELNLE 205 P+V +FG+ + + + D + +G+S HV+ F+ +A G +N+ Sbjct: 237 PNVTFFGDNVPGSKVTFVRSIVDKCDGVLVVGSSLHVWSGYRFITQAHELGVPIAIVNVG 296 Query: 206 PSQVGNEFAEKYYGPASQVVPEF 228 ++ A K + V Sbjct: 297 ETRADKFAAVKIDALCTDVFHAI 319 Database: uniref50.fasta Posted date: Mar 8, 2010 10:38 AM Number of letters in database: 1,040,396,356 Number of sequences in database: 3,077,464 Lambda K H 0.314 0.149 0.446 Lambda K H 0.267 0.0457 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 1,691,421,492 Number of Sequences: 3077464 Number of extensions: 75160656 Number of successful extensions: 255695 Number of sequences better than 1.0e-01: 250 Number of HSP's better than 0.1 without gapping: 1222 Number of HSP's successfully gapped in prelim test: 529 Number of HSP's that attempted gapping in prelim test: 248563 Number of HSP's gapped (non-prelim): 2157 length of query: 242 length of database: 1,040,396,356 effective HSP length: 125 effective length of query: 117 effective length of database: 655,713,356 effective search space: 76718462652 effective search space used: 76718462652 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.3 bits) S2: 91 (39.5 bits)