BLASTP 2.2.22 [Sep-27-2009]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.


Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.


Reference for composition-based statistics starting in round 2:
Schaffer, Alejandro A., L. Aravind, Thomas L. Madden,
Sergei Shavirin, John L. Spouge, Yuri I. Wolf,  
Eugene V. Koonin, and Stephen F. Altschul (2001), 
"Improving the accuracy of PSI-BLAST protein database searches with 
composition-based statistics and other refinements",  Nucleic Acids Res. 29:2994-3005.

Query= batch____
         (196 letters)

Database: uniref50.fasta 
           3,077,464 sequences; 1,040,396,356 total letters

Searching..................................................done


Results from round 1


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

UniRef50_A6T7Y5 GTP cyclohydrolase-2 n=139 Tax=cellular organism...   383   e-105
UniRef50_Q4QNX8 GTP cyclohydrolase-2 n=78 Tax=cellular organisms...   273   3e-72
UniRef50_P57863 GTP cyclohydrolase-2 n=17 Tax=Proteobacteria Rep...   269   4e-71
UniRef50_Q65SC0 GTP cyclohydrolase-2 n=55 Tax=Bacteria RepID=RIB...   268   7e-71
UniRef50_Q2SA07 GTP cyclohydrolase-2 n=16 Tax=Bacteria RepID=RIB...   267   1e-70
UniRef50_A4VHT9 GTP cyclohydrolase-2 n=5 Tax=Proteobacteria RepI...   250   2e-65
UniRef50_Q5F7N6 GTP cyclohydrolase-2 n=33 Tax=Bacteria RepID=RIB...   244   1e-63
UniRef50_C4GH90 GTP cyclohydrolase-2 n=1 Tax=Kingella oralis ATC...   240   2e-62
UniRef50_C5D3N0 GTP cyclohydrolase-2 n=25 Tax=cellular organisms...   231   1e-59
UniRef50_C0VNE9 GTP cyclohydrolase-2 n=2 Tax=Moraxellaceae RepID...   228   6e-59
UniRef50_P74104 GTP cyclohydrolase-2 n=580 Tax=cellular organism...   213   3e-54
UniRef50_Q1GKN3 GTP cyclohydrolase-2 n=44 Tax=Rhodobacterales Re...   208   1e-52
UniRef50_C4Z7I1 GTP cyclohydrolase II / 3,4-dihydroxy 2-butanone...   206   5e-52
UniRef50_C8WEC3 GTP cyclohydrolase-2 n=10 Tax=Sphingomonadales R...   203   2e-51
UniRef50_P43525 GTP cyclohydrolase-2 n=6 Tax=Alphaproteobacteria...   202   7e-51
UniRef50_UPI0001905AE1 GTP cyclohydrolase II protein n=1 Tax=Rhi...   198   1e-49
UniRef50_C9M9Y1 3,4-dihydroxy-2-butanone 4-phosphate synthase/GT...   197   2e-49
UniRef50_Q11WK6 GTP cyclohydrolase-2 n=44 Tax=Bacteria RepID=RIB...   196   3e-49
UniRef50_O84736 GTP cyclohydrolase-2 n=38 Tax=Bacteria RepID=RIB...   195   5e-49
UniRef50_Q4FV65 GTP cyclohydrolase-2 n=3 Tax=Psychrobacter RepID...   195   7e-49
UniRef50_A1T8K1 GTP cyclohydrolase-2 n=43 Tax=cellular organisms...   193   2e-48
UniRef50_B8JBX2 GTP cyclohydrolase-2 n=5 Tax=Bacteria RepID=B8JB...   193   3e-48
UniRef50_Q1IPQ1 GTP cyclohydrolase-2 n=4 Tax=Bacteria RepID=Q1IP...   193   3e-48
UniRef50_A0PPL6 GTP cyclohydrolase-2 n=82 Tax=Bacteria RepID=RIB...   193   3e-48
UniRef50_C9KJZ5 3,4-dihydroxy-2-butanone 4-phosphate synthase/GT...   192   5e-48
UniRef50_Q1D4N5 GTP cyclohydrolase-2 n=6 Tax=Cystobacterineae Re...   192   7e-48
UniRef50_D0LLG6 GTP cyclohydrolase-2 n=1 Tax=Haliangium ochraceu...   191   1e-47
UniRef50_A5G2C3 GTP cyclohydrolase-2 n=2 Tax=Rhodospirillales Re...   191   2e-47
UniRef50_C5CJ14 GTP cyclohydrolase II n=1 Tax=Kosmotoga olearia ...   190   2e-47
UniRef50_B9L8K1 GTP cyclohydrolase-2 n=3 Tax=Bacteria RepID=B9L8...   189   6e-47
UniRef50_Q13NP8 GTP cyclohydrolase-2 n=9 Tax=cellular organisms ...   188   8e-47
UniRef50_C7NTK7 GTP cyclohydrolase II n=1 Tax=Halorhabdus utahen...   185   7e-46
UniRef50_B0RC63 Riboflavin biosynthesis protein RibA n=7 Tax=Act...   184   2e-45
UniRef50_D2R1R5 GTP cyclohydrolase II n=3 Tax=Planctomycetaceae ...   183   2e-45
UniRef50_A6C5C2 Riboflavin biosynthesis protein RibA n=1 Tax=Pla...   182   4e-45
UniRef50_D2RDK3 GTP cyclohydrolase II n=2 Tax=Archaeoglobaceae R...   182   5e-45
UniRef50_P47924 GTP cyclohydrolase-2 n=36 Tax=cellular organisms...   180   2e-44
UniRef50_A6G7P6 GTP cyclohydrolase-2 n=1 Tax=Plesiocystis pacifi...   180   2e-44
UniRef50_C9MTM9 GTP cyclohydrolase-2 n=1 Tax=Prevotella verorali...   180   3e-44
UniRef50_C7JCF3 Bifunctional protein 3,4-dihydroxy-2-butanone 4-...   179   4e-44
UniRef50_B9HF78 Predicted protein (Fragment) n=10 Tax=cellular o...   179   5e-44
UniRef50_Q9X2E6 GTP cyclohydrolase-2 n=13 Tax=cellular organisms...   179   7e-44
UniRef50_Q7VK48 GTP cyclohydrolase-2 n=2 Tax=Helicobacteraceae R...   177   2e-43
UniRef50_A0RR75 GTP cyclohydrolase-2 n=10 Tax=Epsilonproteobacte...   177   2e-43
UniRef50_D1IKX7 Whole genome shotgun sequence of line PN40024, s...   176   3e-43
UniRef50_D1BH22 GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4...   176   5e-43
UniRef50_Q6GFT5 GTP cyclohydrolase-2 n=76 Tax=Bacteria RepID=RIB...   176   5e-43
UniRef50_A9FWS8 GTP cyclohydrolase-2 n=1 Tax=Sorangium cellulosu...   176   5e-43
UniRef50_C6V5M6 GTP cyclohydrolase-2 n=2 Tax=Neorickettsia RepID...   176   5e-43
UniRef50_Q604R2 Riboflavin-specific deaminase/GTP cyclohydrolase...   175   7e-43
UniRef50_Q4L7B1 GTP cyclohydrolase-2 n=3 Tax=Staphylococcus RepI...   174   1e-42
UniRef50_A0JVK1 GTP cyclohydrolase-2 n=2 Tax=Micrococcaceae RepI...   174   1e-42
UniRef50_C0YM11 GTP cyclohydrolase-2 n=2 Tax=Chryseobacterium gl...   174   1e-42
UniRef50_B7IF97 A 3,4-dihydroxy-2-butanone 4-phosphate synthase/...   173   2e-42
UniRef50_UPI000050F87F bifunctional 3,4-dihydroxy-2-butanone 4-p...   173   4e-42
UniRef50_A7I3X0 GTP cyclohydrolase-2 n=6 Tax=cellular organisms ...   172   6e-42
UniRef50_C6X006 GTP cyclohydrolase-2 n=1 Tax=Flavobacteriaceae b...   172   7e-42
UniRef50_Q17XC9 GTP cyclohydrolase-2 n=13 Tax=Helicobacter RepID...   171   8e-42
UniRef50_C4K9I6 GTP cyclohydrolase-2 n=1 Tax=Thauera sp. MZ1T Re...   168   1e-40
UniRef50_B8H6T8 GTP cyclohydrolase-2 n=1 Tax=Arthrobacter chloro...   167   2e-40
UniRef50_Q1QYD0 GTP cyclohydrolase-2 n=1 Tax=Chromohalobacter sa...   167   2e-40
UniRef50_A6VWW9 GTP cyclohydrolase-2 n=47 Tax=Bacteria RepID=RIB...   166   3e-40
UniRef50_A8IZV5 Bifunctional GTP cyclohydrolase II n=1 Tax=Chlam...   165   7e-40
UniRef50_B9ZQZ7 GTP cyclohydrolase-2 n=1 Tax=Thioalkalivibrio sp...   164   1e-39
UniRef50_D2LG53 GTP cyclohydrolase II n=1 Tax=Rhodomicrobium van...   164   1e-39
UniRef50_O29766 GTP cyclohydrolase-2 n=1 Tax=Archaeoglobus fulgi...   163   3e-39
UniRef50_Q03XZ0 GTP cyclohydrolase II n=1 Tax=Leuconostoc mesent...   162   6e-39
UniRef50_A4XHM6 GTP cyclohydrolase II n=2 Tax=Clostridia RepID=A...   162   8e-39
UniRef50_A4RYG5 Predicted protein n=1 Tax=Ostreococcus lucimarin...   161   9e-39
UniRef50_A1SSA8 GTP cyclohydrolase-2 n=10 Tax=Gammaproteobacteri...   160   3e-38
UniRef50_P51618 GTP cyclohydrolase-2 n=63 Tax=Gammaproteobacteri...   159   4e-38
UniRef50_C1E155 Predicted protein n=2 Tax=Micromonas RepID=C1E15...   159   5e-38
UniRef50_D2NTM1 GTP cyclohydrolase II n=2 Tax=Rothia mucilaginos...   156   4e-37
UniRef50_A6W477 GTP cyclohydrolase-2 n=8 Tax=Bacteria RepID=A6W4...   155   7e-37
UniRef50_D0NCB5 Riboflavin biosynthesis protein ribBA, putative ...   155   9e-37
UniRef50_Q83FM7 GTP cyclohydrolase-2 n=2 Tax=Tropheryma whipplei...   154   1e-36
UniRef50_Q87D69 GTP cyclohydrolase-2 n=22 Tax=Proteobacteria Rep...   154   2e-36
UniRef50_C6QGG9 GTP cyclohydrolase-2 n=1 Tax=Hyphomicrobium deni...   153   2e-36
UniRef50_B3CNI0 GTP cyclohydrolase-2 n=13 Tax=Wolbachia RepID=B3...   151   1e-35
UniRef50_UPI000051036D riboflavin-specific deaminase/GTP cyclohy...   151   1e-35
UniRef50_C5AMM6 GTP cyclohydrolase-2 n=2 Tax=Burkholderia glumae...   149   6e-35
UniRef50_Q4V1U4 GTP cyclohydrolase-2 n=26 Tax=Bacillus cereus gr...   146   3e-34
UniRef50_A8FIW0 GTP cyclohydrolase-2 n=7 Tax=Bacillales RepID=A8...   144   1e-33
UniRef50_Q3YT81 GTP cyclohydrolase-2 n=6 Tax=canis group RepID=Q...   144   2e-33
UniRef50_B0UFT4 GTP cyclohydrolase-2 n=4 Tax=Rhizobiales RepID=B...   144   2e-33
UniRef50_A8NX34 GTP cyclohydrolase-2 n=2 Tax=Agaricales RepID=A8...   143   4e-33
UniRef50_P50139 GTP cyclohydrolase-2 n=33 Tax=Ascomycota RepID=R...   142   5e-33
UniRef50_B2GGU5 GTP cyclohydrolase-2 n=1 Tax=Kocuria rhizophila ...   142   5e-33
UniRef50_B9KHB1 GTP cyclohydrolase-2 n=5 Tax=Anaplasma RepID=B9K...   138   9e-32
UniRef50_A6MYZ0 GTP cyclohydrolase-2 n=2 Tax=Saccharomycetaceae ...   136   5e-31
UniRef50_Q5KNS2 GTP cyclohydrolase-2 n=1 Tax=Filobasidiella neof...   135   8e-31
UniRef50_Q4P4Y7 GTP cyclohydrolase-2 n=2 Tax=Basidiomycota RepID...   135   1e-30
UniRef50_C7R1D1 3,4-dihydroxy-2-butanone 4-phosphate synthase n=...   134   1e-30
UniRef50_C5LSF0 GTP cyclohydrolase II, putative (Fragment) n=1 T...   133   3e-30
UniRef50_A0Z3E0 GTP cyclohydrolase-2 n=1 Tax=marine gamma proteo...   131   1e-29
UniRef50_C9S9H3 GTP cyclohydrolase-2 n=1 Tax=Verticillium albo-a...   130   2e-29
UniRef50_A6DFW0 GTP cyclohydrolase-2 n=1 Tax=Lentisphaera araneo...   130   3e-29
UniRef50_P38066 GTP cyclohydrolase-2 n=8 Tax=Saccharomycetales R...   129   4e-29
UniRef50_B8KSW9 GTP cyclohydrolase-2 n=1 Tax=gamma proteobacteri...   123   3e-27
UniRef50_A1SF04 GTP cyclohydrolase-2 n=16 Tax=Bacteria RepID=A1S...   123   4e-27
UniRef50_A8PZB1 GTP cyclohydrolase-2 n=1 Tax=Malassezia globosa ...   122   9e-27
UniRef50_Q14FW6 Riboflavin biosynthesis protein ribA/GTP-cyclohy...   121   1e-26
UniRef50_C5RMY3 GTP cyclohydrolase-2 n=1 Tax=Clostridium cellulo...   119   6e-26
UniRef50_C0A9J6 GTP cyclohydrolase-2 n=1 Tax=Opitutaceae bacteri...   117   3e-25
UniRef50_C9PF77 GTP cyclohydrolase II n=1 Tax=Vibrio furnissii C...   116   4e-25
UniRef50_A5ARE3 Putative uncharacterized protein n=1 Tax=Vitis v...   115   1e-24
UniRef50_Q5YVN1 GTP cyclohydrolase-2 n=1 Tax=Nocardia farcinica ...   114   1e-24
UniRef50_A8FAX3 GTP cyclohydrolase-2 n=2 Tax=Bacillus pumilus Re...   113   3e-24
UniRef50_Q2S6L1 3,4-dihydroxy-2-butanone 4-phosphate synthase/GT...   106   4e-22
UniRef50_Q0D0K3 GTP cyclohydrolase-2 n=29 Tax=Leotiomyceta RepID...   102   7e-21
UniRef50_A2TRN2 GTP cyclohydrolase-2 n=1 Tax=Dokdonia donghaensi...   100   4e-20
UniRef50_Q08VV8 GTP cyclohydrolase-2 n=1 Tax=Stigmatella auranti...    98   1e-19
UniRef50_Q6KH48 GTP cyclohydrolase-2 n=1 Tax=Mycoplasma mobile R...    97   2e-19
UniRef50_D0L7U8 3,4-dihydroxy-2-butanone 4-phosphate synthase n=...    97   2e-19
UniRef50_Q59AD7 GTP cyclohydrolase-2 (Fragment) n=2 Tax=Buchnera...    97   4e-19
UniRef50_A0SNY3 Riboflavin biosynthesis protein RibA n=2 Tax=Can...    89   6e-17
UniRef50_Q1AV39 GTP cyclohydrolase-2 n=1 Tax=Rubrobacter xylanop...    82   9e-15
UniRef50_A9QS81 GTP cyclohydrolase-2 n=1 Tax=Lactococcus lactis ...    78   1e-13
UniRef50_Q1AZ21 GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone...    74   3e-12
UniRef50_Q9R6K1 GTP cyclohydrolase-2 n=1 Tax=Agrobacterium tumef...    73   5e-12
UniRef50_A6G9U6 3,4-dihydroxy-2-butanone 4-phosphate synthase/GT...    72   1e-11
UniRef50_A0PS46 Riboflavin biosynthesis protein RibA1 n=16 Tax=C...    71   3e-11
UniRef50_A0SNY4 Riboflavin biosynthesis protein RibA n=2 Tax=Can...    64   3e-09
UniRef50_C5FIC6 GTP cyclohydrolase-2 n=1 Tax=Microsporum canis C...    63   5e-09
UniRef50_Q6MIV8 GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone...    62   2e-08
UniRef50_D0NXG3 Putative uncharacterized protein n=1 Tax=Phytoph...    61   2e-08
UniRef50_C0YN89 3,4-dihydroxy-2-butanone-4-phosphate synthase n=...    60   3e-08
UniRef50_B5JMM0 3,4-dihydroxy-2-butanone 4-phosphate synthase fa...    60   3e-08
UniRef50_C6X067 3,4-dihydroxy-2-butanone 4-phosphate synthase / ...    60   4e-08
UniRef50_A6DFW1 3,4-dihydroxy-2-butanone 4-phosphate synthase/GT...    59   1e-07
UniRef50_A0M3F6 Riboflavin biosynthesis protein n=17 Tax=Bactero...    58   2e-07
UniRef50_Q1DG18 GTP cyclohydrolase-2 n=2 Tax=Bacteria RepID=Q1DG...    56   6e-07
UniRef50_Q1GEQ5 GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone...    56   6e-07
UniRef50_UPI0001C31D71 34-dihydroxy-2-butanone 4-phosphate synth...    56   7e-07
UniRef50_D1ZD95 GTP cyclohydrolase-2 n=1 Tax=Sordaria macrospora...    56   8e-07
UniRef50_B7FNY5 Predicted protein n=1 Tax=Phaeodactylum tricornu...    55   1e-06
UniRef50_Q882G0 3,4-dihydroxy-2-butanone 4-phosphate synthase n=...    53   5e-06
UniRef50_A4A6E4 Riboflavin biosynthesis protein ribA n=5 Tax=unc...    53   5e-06
UniRef50_Q2NZ90 3,4-dihydroxy-2-butanone 4-phosphate synthase n=...    53   5e-06
UniRef50_Q9US41 Uracil-regulated protein 1 n=101 Tax=cellular or...    53   7e-06
UniRef50_D2UG04 Putative gtp cyclohydrolase II 3, 4-dihydroxy-2-...    52   1e-05
UniRef50_B4RM34 3,4-dihydroxy-2-butanone 4-phosphate synthase n=...    52   1e-05
UniRef50_C0XBJ0 GTP cyclohydrolase-2 n=3 Tax=Lactobacillus gasse...    52   1e-05
UniRef50_B2AIS6 RIBOFLAVIN BIOSYNTHESIS BIFUNCTIONAL PROTEIN : G...    50   5e-05
UniRef50_UPI0001BCED67 bifunctional 3,4-dihydroxy-2-butanone 4-p...    49   6e-05
UniRef50_A7IMW5 3,4-dihydroxy-2-butanone 4-phosphate synthase n=...    49   7e-05
UniRef50_A8PF74 GTP cyclohydrolase-2 n=1 Tax=Coprinopsis cinerea...    48   2e-04
UniRef50_D0LW49 3,4-dihydroxy-2-butanone 4-phosphate synthase n=...    47   2e-04
UniRef50_Q5K843 GTP cyclohydrolase-2 n=5 Tax=Eukaryota RepID=Q5K...    47   3e-04
UniRef50_A4JQ12 GTP cyclohydrolase II n=9 Tax=Proteobacteria Rep...    47   5e-04
UniRef50_C1HDW1 GTP cyclohydrolase-2 n=2 Tax=Onygenales RepID=C1...    45   0.002
UniRef50_A6RZS8 GTP cyclohydrolase-2 n=1 Tax=Botryotinia fuckeli...    45   0.002
UniRef50_Q0E2P5 Os02g0223200 protein (Fragment) n=2 Tax=Oryza sa...    43   0.005
UniRef50_UPI0001850D2C bifunctional 3,4-dihydroxy-2-butanone 4-p...    43   0.006

>UniRef50_A6T7Y5 GTP cyclohydrolase-2 n=139 Tax=cellular organisms RepID=RIBA_KLEP7
          Length = 200

 Score =  383 bits (983), Expect = e-105,   Method: Compositional matrix adjust.
 Identities = 184/196 (93%), Positives = 187/196 (95%)

Query: 1   MQLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDAL 60
           MQLKRVAEAKLPTPWGDFLMVGFEELATG DHVALVYGDISG +PVLARVHSECLTGDAL
Sbjct: 1   MQLKRVAEAKLPTPWGDFLMVGFEELATGQDHVALVYGDISGQSPVLARVHSECLTGDAL 60

Query: 61  FSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQ 120
           FSLRCDCGFQLEAAL+ IAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQ
Sbjct: 61  FSLRCDCGFQLEAALSHIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQ 120

Query: 121 LGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNE 180
           LGFAADERDFTLCADMFKLL V +VRLLTNNPKKVEILTEAGINIVERVPLIVGRNP N 
Sbjct: 121 LGFAADERDFTLCADMFKLLNVEQVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPKNA 180

Query: 181 HYLDTKAEKMGHLLNK 196
           HYLDTKA KMGHLLN 
Sbjct: 181 HYLDTKAAKMGHLLNS 196


>UniRef50_Q4QNX8 GTP cyclohydrolase-2 n=78 Tax=cellular organisms RepID=RIBA_HAEI8
          Length = 216

 Score =  273 bits (697), Expect = 3e-72,   Method: Compositional matrix adjust.
 Identities = 132/194 (68%), Positives = 158/194 (81%), Gaps = 1/194 (0%)

Query: 2   QLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDIS-GHTPVLARVHSECLTGDAL 60
           +++ VA+A LPT +G F MVGFE   T  +HVALV GDIS    PVLAR+HSECLTGDAL
Sbjct: 3   KIQLVAQANLPTEYGIFKMVGFEFPDTKKEHVALVMGDISNADEPVLARIHSECLTGDAL 62

Query: 61  FSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQ 120
            SL+CDCGFQL  AL QI EEGRG+L+YHR+EGR IGL+NKIRAY+LQD+G DT+EAN  
Sbjct: 63  HSLKCDCGFQLATALKQIQEEGRGVLIYHREEGRGIGLINKIRAYSLQDKGMDTIEANLA 122

Query: 121 LGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNE 180
           LGF ADER+F +CADMF+LLGV +VRL+TNNP+KVE + +AGIN+VERVPL VG N  N 
Sbjct: 123 LGFKADERNFEVCADMFELLGVKKVRLMTNNPEKVETMKKAGINVVERVPLNVGENRYNT 182

Query: 181 HYLDTKAEKMGHLL 194
            YLDTKA+KMGH +
Sbjct: 183 KYLDTKAKKMGHYI 196


>UniRef50_P57863 GTP cyclohydrolase-2 n=17 Tax=Proteobacteria RepID=RIBA_PASMU
          Length = 219

 Score =  269 bits (688), Expect = 4e-71,   Method: Compositional matrix adjust.
 Identities = 127/194 (65%), Positives = 159/194 (81%), Gaps = 1/194 (0%)

Query: 2   QLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISG-HTPVLARVHSECLTGDAL 60
           +++RV EA LPT +G F +VGFE   T  +HVALV G++     P+LAR+HSECLTGDAL
Sbjct: 3   KIQRVTEANLPTEFGMFRIVGFEFPDTKKEHVALVLGEVENTDEPILARIHSECLTGDAL 62

Query: 61  FSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQ 120
           +SL+CDCGFQL AAL QI++EGRG+L+YHR+EGR IGL+NKIRAY+LQD+G DT+EAN  
Sbjct: 63  YSLKCDCGFQLAAALRQISQEGRGVLIYHREEGRGIGLINKIRAYSLQDKGMDTIEANLA 122

Query: 121 LGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNE 180
           LGFAADER+F +CAD+F LLG+N+VRLLTNNP K++ + +AGINIVERV L VG N  N 
Sbjct: 123 LGFAADERNFEVCADIFALLGINKVRLLTNNPNKIDTMKKAGINIVERVALNVGENRYNT 182

Query: 181 HYLDTKAEKMGHLL 194
            YLDTKA+KMGH +
Sbjct: 183 EYLDTKAKKMGHFI 196


>UniRef50_Q65SC0 GTP cyclohydrolase-2 n=55 Tax=Bacteria RepID=RIBA_MANSM
          Length = 219

 Score =  268 bits (685), Expect = 7e-71,   Method: Compositional matrix adjust.
 Identities = 129/195 (66%), Positives = 158/195 (81%), Gaps = 2/195 (1%)

Query: 2   QLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISG--HTPVLARVHSECLTGDA 59
           +++RVAEA LPT +G F +VGFE   T  +HVALV GDIS     PVLAR+HSECLTGDA
Sbjct: 3   KIQRVAEANLPTEFGLFRIVGFEFPDTKKEHVALVMGDISNSEENPVLARIHSECLTGDA 62

Query: 60  LFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANH 119
           L SL+CDCGFQL  AL QI+E GRG+L+YHR+EGR IGL+NKIRAY+LQD G DT+EAN 
Sbjct: 63  LHSLKCDCGFQLSTALRQISEAGRGVLIYHREEGRGIGLINKIRAYSLQDNGMDTIEANL 122

Query: 120 QLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNN 179
            LGFAADER+F +CAD+F+LLG+ +VRLLTNNP K++ + +AGIN+VER+PL VG N  N
Sbjct: 123 ALGFAADERNFKVCADIFELLGICKVRLLTNNPAKIDTMKKAGINVVERIPLNVGENRYN 182

Query: 180 EHYLDTKAEKMGHLL 194
             YLDTKA+KMGH +
Sbjct: 183 TGYLDTKAKKMGHYI 197


>UniRef50_Q2SA07 GTP cyclohydrolase-2 n=16 Tax=Bacteria RepID=RIBA_HAHCH
          Length = 207

 Score =  267 bits (682), Expect = 1e-70,   Method: Compositional matrix adjust.
 Identities = 129/195 (66%), Positives = 152/195 (77%)

Query: 1   MQLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDAL 60
           M +  VA  KLPTP+G F M GF+E+ T  +H+AL  GDI     VLAR HSECLTGDAL
Sbjct: 1   MSVTYVASCKLPTPFGVFDMHGFQEVGTQKEHIALTLGDIGDGASVLARTHSECLTGDAL 60

Query: 61  FSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQ 120
           FS+RCDCG+QL+ AL  IA EGRGILLY RQEGR IGLLNKIRAY LQDQG DTVEAN Q
Sbjct: 61  FSMRCDCGYQLDEALRSIAAEGRGILLYLRQEGRGIGLLNKIRAYNLQDQGADTVEANEQ 120

Query: 121 LGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNE 180
           LGFAAD RD+++C  M   LG++ +RL+TNNP+KV+ LT+ GI +VERVPL VGRNP+N 
Sbjct: 121 LGFAADMRDYSMCKPMLYHLGISRIRLMTNNPRKVDSLTKLGIEVVERVPLEVGRNPHNR 180

Query: 181 HYLDTKAEKMGHLLN 195
           +YL TKA K+GHLL 
Sbjct: 181 NYLATKAGKLGHLLT 195


>UniRef50_A4VHT9 GTP cyclohydrolase-2 n=5 Tax=Proteobacteria RepID=A4VHT9_PSEU5
          Length = 242

 Score =  250 bits (638), Expect = 2e-65,   Method: Compositional matrix adjust.
 Identities = 120/191 (62%), Positives = 146/191 (76%)

Query: 6   VAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRC 65
           VA ++LPTP+G F M GF +  TG +HVAL  GD++   PVL R+HSECLTGDALFSLRC
Sbjct: 43  VAASQLPTPFGVFTMHGFLDQDTGKEHVALTLGDVADGKPVLGRLHSECLTGDALFSLRC 102

Query: 66  DCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAA 125
           DCGFQLEAAL  IA+EGRG+LLY RQEGR IGLLNKIRAY LQD G DTVEAN +LGFA 
Sbjct: 103 DCGFQLEAALRAIADEGRGVLLYLRQEGRGIGLLNKIRAYELQDAGADTVEANERLGFAP 162

Query: 126 DERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDT 185
           D RD+ +C  M + LG+ E++L+TNNP+KV+ L   GI + ER PL +  NP+N  YL T
Sbjct: 163 DMRDYGICLPMLEHLGIGEIKLMTNNPRKVKALQGFGIRVAERKPLQIAHNPHNRKYLAT 222

Query: 186 KAEKMGHLLNK 196
           KA K+GH+L +
Sbjct: 223 KAGKLGHMLGE 233


>UniRef50_Q5F7N6 GTP cyclohydrolase-2 n=33 Tax=Bacteria RepID=RIBA_NEIG1
          Length = 197

 Score =  244 bits (622), Expect = 1e-63,   Method: Compositional matrix adjust.
 Identities = 118/194 (60%), Positives = 145/194 (74%), Gaps = 1/194 (0%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           L  VA  +LPT WG F M GFEE A G +HVAL  G+ S   PVL R+HSECLTGDALFS
Sbjct: 5   LDHVASCRLPTEWGVFTMHGFEE-ANGQEHVALTVGNCSDGNPVLTRIHSECLTGDALFS 63

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
            +CDCG QLEAA+  +  EGRGI++Y RQEGR IGL+NKIRAY LQ+QG DTVEAN  LG
Sbjct: 64  RKCDCGPQLEAAMRAVQAEGRGIIVYLRQEGRGIGLINKIRAYHLQEQGMDTVEANLALG 123

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHY 182
              D RDF L   +++ LG+  V+LLTNNP+K++ L +AGIN+VER+PL VG N  NE Y
Sbjct: 124 LPVDARDFRLAQSIYEYLGIRSVKLLTNNPEKIQTLKDAGINVVERIPLHVGENLENERY 183

Query: 183 LDTKAEKMGHLLNK 196
           L TKA+K+GHL+++
Sbjct: 184 LQTKADKLGHLMSE 197


>UniRef50_C4GH90 GTP cyclohydrolase-2 n=1 Tax=Kingella oralis ATCC 51147
           RepID=C4GH90_9NEIS
          Length = 235

 Score =  240 bits (612), Expect = 2e-62,   Method: Compositional matrix adjust.
 Identities = 111/192 (57%), Positives = 148/192 (77%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           L+ +   +LPT  G + M G+++  TG +H+ALV GDI+   PVL+RVHSECLTGDALFS
Sbjct: 42  LQHITSCRLPTEHGIYQMHGYQDSQTGQEHIALVMGDITTPEPVLSRVHSECLTGDALFS 101

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
            +CDCG QL+AA+  +A EGRG+++Y RQEGR IGL+NKIRAYALQD+G DTVEAN  LG
Sbjct: 102 QKCDCGPQLKAAMQAVAAEGRGVIVYLRQEGRGIGLINKIRAYALQDKGMDTVEANLALG 161

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHY 182
              D RDFTL  +++  LG+  +RLLTNNP+KV  L +AGI+I ER+PL VG +P N++Y
Sbjct: 162 LPVDARDFTLAKEIYDHLGIRSIRLLTNNPEKVHTLQQAGIHITERLPLHVGIHPENQNY 221

Query: 183 LDTKAEKMGHLL 194
           L+TKA+K+ H++
Sbjct: 222 LNTKAQKLNHMM 233


>UniRef50_C5D3N0 GTP cyclohydrolase-2 n=25 Tax=cellular organisms RepID=RIBBA_GEOSW
          Length = 397

 Score =  231 bits (588), Expect = 1e-59,   Method: Compositional matrix adjust.
 Identities = 114/193 (59%), Positives = 139/193 (72%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           +KR  E  LPT +G F  +G+  +  G +HVALV G+I    P L RVHSECLTGD   S
Sbjct: 204 VKREVEVMLPTEFGKFKAIGYTNIVDGKEHVALVKGEIIPDEPTLVRVHSECLTGDVFGS 263

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
            RCDCG QL AAL QI EEGRG+LLY RQEGR IGL+NK+RAY LQ+QGYDTVEAN +LG
Sbjct: 264 CRCDCGPQLHAALRQIEEEGRGVLLYMRQEGRGIGLINKLRAYKLQEQGYDTVEANERLG 323

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHY 182
           F AD RD+ + A + K LGV ++RLLTNNP+K+  L   G+ +VERVPL +  N  NE Y
Sbjct: 324 FPADLRDYGIGAQILKDLGVTKMRLLTNNPRKITGLKGHGLEVVERVPLQMPANKENEKY 383

Query: 183 LDTKAEKMGHLLN 195
           L TK EK+GH+L+
Sbjct: 384 LRTKYEKLGHMLH 396


>UniRef50_C0VNE9 GTP cyclohydrolase-2 n=2 Tax=Moraxellaceae RepID=C0VNE9_9GAMM
          Length = 252

 Score =  228 bits (582), Expect = 6e-59,   Method: Compositional matrix adjust.
 Identities = 114/192 (59%), Positives = 141/192 (73%), Gaps = 1/192 (0%)

Query: 6   VAEAKLPTPWGDFLMVGFEELATGHDHVALVYG-DISGHTPVLARVHSECLTGDALFSLR 64
           +A +KLPT +GDF +  F++  TG +HVAL  G + + + PVL R+HSECLTGDA  SL+
Sbjct: 58  IATSKLPTAFGDFNISVFQDPETGEEHVALSKGLETAPNQPVLVRIHSECLTGDAFASLK 117

Query: 65  CDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFA 124
           CDCG QL+A    I E G+G++LY RQEGR IGL NKIRAYALQDQG+DTV+AN  L   
Sbjct: 118 CDCGPQLQATQRLINEAGQGVILYLRQEGRGIGLTNKIRAYALQDQGHDTVDANLLLNLP 177

Query: 125 ADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLD 184
           AD R + +C+ M   L V EV+LLTNNP K++ LT+ GIN+VERVPL VGRNP NEHYL 
Sbjct: 178 ADARRYDMCSIMLDHLQVKEVKLLTNNPLKLKALTDLGINVVERVPLTVGRNPFNEHYLK 237

Query: 185 TKAEKMGHLLNK 196
           TK E+M HL  K
Sbjct: 238 TKRERMDHLYKK 249


>UniRef50_P74104 GTP cyclohydrolase-2 n=580 Tax=cellular organisms RepID=RIBBA_SYNY3
          Length = 556

 Score =  213 bits (541), Expect = 3e-54,   Method: Compositional matrix adjust.
 Identities = 104/196 (53%), Positives = 138/196 (70%), Gaps = 2/196 (1%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDIS--GHTPVLARVHSECLTGDAL 60
           ++R    + P+ +G+F +  +  L    +H+A+V GD S  G  PV+ R+HSECLTGDAL
Sbjct: 207 VQRETICEFPSQFGEFKLYAYRNLLDQTEHIAIVKGDPSEFGQQPVMVRMHSECLTGDAL 266

Query: 61  FSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQ 120
            SLRCDC  QL+AAL  +   G G+++Y RQEGR IGL+NK++AY+LQD GYDTVEAN +
Sbjct: 267 GSLRCDCRMQLQAALKMLENHGLGVVVYLRQEGRGIGLVNKLKAYSLQDLGYDTVEANER 326

Query: 121 LGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNE 180
           LGF AD RD+ + A M   LGV ++RL+TNNP+K+  L   G+ IVERVPL++  N  N 
Sbjct: 327 LGFPADLRDYGMGAQMLNDLGVKQIRLITNNPRKIAGLKGYGLEIVERVPLLIEANDYNS 386

Query: 181 HYLDTKAEKMGHLLNK 196
           HYL TKAEK+GH L K
Sbjct: 387 HYLTTKAEKLGHWLVK 402


>UniRef50_Q1GKN3 GTP cyclohydrolase-2 n=44 Tax=Rhodobacterales RepID=Q1GKN3_SILST
          Length = 362

 Score =  208 bits (529), Expect = 1e-52,   Method: Compositional matrix adjust.
 Identities = 99/166 (59%), Positives = 121/166 (72%)

Query: 29  GHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQIAEEGRGILLY 88
           G +H A+  G      PVLAR+HS C TGD L SL+CDCG QL  AL+ + +EG GILLY
Sbjct: 197 GEEHYAIEIGRPDRSQPVLARLHSACFTGDVLGSLKCDCGPQLRGALSHMGQEGAGILLY 256

Query: 89  HRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNEVRLL 148
             QEGR IGL NK+RAY+LQDQG+DTVEANH+LGF  DERDF L A + + LG + VRL+
Sbjct: 257 LNQEGRGIGLANKMRAYSLQDQGFDTVEANHRLGFEDDERDFRLGASILRELGFSSVRLM 316

Query: 149 TNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAEKMGHLL 194
           TNNP K+ ++ + GI++VERVPL VG N  N HYL TKA K GH+L
Sbjct: 317 TNNPGKIAMMEKTGISVVERVPLKVGENAFNRHYLATKAAKSGHML 362


>UniRef50_C4Z7I1 GTP cyclohydrolase II / 3,4-dihydroxy 2-butanone 4-phosphate
           synthase n=19 Tax=Bacteria RepID=C4Z7I1_EUBE2
          Length = 400

 Score =  206 bits (523), Expect = 5e-52,   Method: Compositional matrix adjust.
 Identities = 103/190 (54%), Positives = 129/190 (67%)

Query: 6   VAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRC 65
           VA  ++PT +G+F    +     G  HVALV GDI   + +L RVHSECLTGDA  S++C
Sbjct: 209 VAVTRMPTKYGEFTAHCYVNKLNGEHHVALVKGDIGDGSNLLCRVHSECLTGDAFGSMKC 268

Query: 66  DCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAA 125
           DCG QL +A+TQI  EGRG+LLY RQEGR IGL+NK++AYALQDQG DT+EAN  LG   
Sbjct: 269 DCGQQLASAMTQINNEGRGVLLYMRQEGRGIGLVNKLKAYALQDQGMDTLEANLALGLPG 328

Query: 126 DERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDT 185
           D R++ + A + K LG   +RLLTNNP KV  L + GI I ERVP+ +     +  YL T
Sbjct: 329 DAREYYIGAQILKDLGAKSLRLLTNNPDKVYQLADFGIEISERVPIEIDATSFDRFYLKT 388

Query: 186 KAEKMGHLLN 195
           K  KMGH+LN
Sbjct: 389 KQTKMGHILN 398


>UniRef50_C8WEC3 GTP cyclohydrolase-2 n=10 Tax=Sphingomonadales RepID=C8WEC3_ZYMMN
          Length = 364

 Score =  203 bits (517), Expect = 2e-51,   Method: Compositional matrix adjust.
 Identities = 105/195 (53%), Positives = 133/195 (68%), Gaps = 8/195 (4%)

Query: 7   AEAKLPTPWGDF-------LMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDA 59
           A A+LP   GD         +V F   A   +HVA++ G   G  PV+ R+HSECLTGD 
Sbjct: 171 ARARLPIALGDHGKAIENSQIVAFRNDADAVEHVAVIIGHPDGQPPVV-RLHSECLTGDV 229

Query: 60  LFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANH 119
             SL+CDCG QL  AL  + E G GILLY RQEGR IGL+NK+RAY+LQDQG+DTV+AN 
Sbjct: 230 FGSLKCDCGPQLHQALRIMDESGYGILLYLRQEGRGIGLINKLRAYSLQDQGFDTVDANV 289

Query: 120 QLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNN 179
           +LGF  D RDF L A M   L + ++RLLTNNP KVE L +AGI++VER+PL +  NP+N
Sbjct: 290 RLGFVNDARDFRLAAQMLGELEIKQIRLLTNNPDKVEGLKKAGIDVVERLPLKIKPNPHN 349

Query: 180 EHYLDTKAEKMGHLL 194
           + YL+TK ++ GH L
Sbjct: 350 QAYLETKRDRSGHQL 364


>UniRef50_P43525 GTP cyclohydrolase-2 n=6 Tax=Alphaproteobacteria RepID=RIBA_AZOBR
          Length = 385

 Score =  202 bits (513), Expect = 7e-51,   Method: Compositional matrix adjust.
 Identities = 100/193 (51%), Positives = 131/193 (67%), Gaps = 1/193 (0%)

Query: 3   LKRVAEAKLPTPWGD-FLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALF 61
           L+RVAEA++P    +   +  F  +  G +H+A++ G+     PVLAR+HSEC TGD L 
Sbjct: 193 LRRVAEARVPLSGAENTSIAAFRPIDGGPEHLAIIVGNPVAGEPVLARLHSECFTGDLLA 252

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
            LRCDCG QL  A+ +IA  G G+LLY  QEGR IGL+NK+RAY +QD+G+DTV+AN  L
Sbjct: 253 GLRCDCGQQLRGAIAEIARHGSGVLLYLAQEGRGIGLVNKLRAYRIQDRGFDTVDANEIL 312

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181
           GF ADER +   A+M + LG   VRL+TNNP+K+  L   GI +VERVP I   N +NE 
Sbjct: 313 GFEADERVYLPAAEMLRQLGFTAVRLMTNNPEKLRQLARCGIEVVERVPHIFPANGHNEG 372

Query: 182 YLDTKAEKMGHLL 194
           YL TKAE+ GH+ 
Sbjct: 373 YLRTKAERSGHMF 385


>UniRef50_UPI0001905AE1 GTP cyclohydrolase II protein n=1 Tax=Rhizobium etli 8C-3
           RepID=UPI0001905AE1
          Length = 222

 Score =  198 bits (503), Expect = 1e-49,   Method: Compositional matrix adjust.
 Identities = 96/196 (48%), Positives = 133/196 (67%), Gaps = 1/196 (0%)

Query: 2   QLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALF 61
           ++KR A++ +PT +GDF  + + +  TG +H+AL  G++     VL RVHSECLTG+A  
Sbjct: 1   RVKRYAQSFMPTRFGDFKAIAYRDSLTGTEHLALTLGELCEKEDVLVRVHSECLTGEAFR 60

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVEANHQ 120
           S+RCDCG QLE AL  +   G G ++Y R QEGR IGL NKI AY+LQD G DT+EAN +
Sbjct: 61  SMRCDCGQQLEMALRAVQLAGAGCVIYMRGQEGRGIGLGNKIAAYSLQDHGRDTLEANRE 120

Query: 121 LGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNE 180
           LGFA+D R++   AD+ + LG+  VRLLTNNP K+E L  +G+ +  R  LI   + +N 
Sbjct: 121 LGFASDSREYNAAADIIRDLGIGSVRLLTNNPTKIEALRTSGVIVSSRQSLIAASSASNI 180

Query: 181 HYLDTKAEKMGHLLNK 196
            YL TK ++ GHLL++
Sbjct: 181 TYLKTKRDRFGHLLDQ 196


>UniRef50_C9M9Y1 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
           n=1 Tax=Jonquetella anthropi E3_33 E1 RepID=C9M9Y1_9BACT
          Length = 416

 Score =  197 bits (500), Expect = 2e-49,   Method: Compositional matrix adjust.
 Identities = 99/196 (50%), Positives = 133/196 (67%), Gaps = 3/196 (1%)

Query: 3   LKRVAEAKLPTPWGDFLMVGF-EELATGHD--HVALVYGDISGHTPVLARVHSECLTGDA 59
           ++RVA   LP+ WGDF  + +  +L T  D  H+ALV GD+S     L RVHSEC+TGD 
Sbjct: 211 IERVASVHLPSAWGDFSAIAYRSQLETDPDRVHIALVKGDLSKEDAPLVRVHSECMTGDV 270

Query: 60  LFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANH 119
             SLRCDCG QL AA++ +   G G++LY RQEGR IGL+ K+RAY LQ++G DTV+AN 
Sbjct: 271 FGSLRCDCGPQLHAAMSMVERAGCGVVLYMRQEGRGIGLVEKLRAYELQEKGLDTVDANL 330

Query: 120 QLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNN 179
            LG   D RD+ + A + K LG+ ++RLLTNNP K+  L   G+ +VERVPL +  N  N
Sbjct: 331 ALGHKPDLRDYGVGAQILKDLGITKLRLLTNNPAKIVGLQGHGLEVVERVPLEIEPNRYN 390

Query: 180 EHYLDTKAEKMGHLLN 195
           + Y+ TK ++MGHLL+
Sbjct: 391 KKYMTTKEDRMGHLLH 406


>UniRef50_Q11WK6 GTP cyclohydrolase-2 n=44 Tax=Bacteria RepID=RIBBA_CYTH3
          Length = 405

 Score =  196 bits (499), Expect = 3e-49,   Method: Compositional matrix adjust.
 Identities = 94/194 (48%), Positives = 129/194 (66%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           +KR     +PT  GDF ++ F +++TG  H+AL+ G      PV+ RVHS C+TGD   S
Sbjct: 210 VKREIGVDMPTNLGDFDLIAFRQISTGEVHLALIKGTWEKDEPVMVRVHSSCVTGDIFGS 269

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
            RCDCG QL  A+  I +EG+G++LY  QEGR IGLLNK++AY LQ+QG DTVEAN +LG
Sbjct: 270 CRCDCGPQLHKAMEMIQQEGKGVILYMNQEGRGIGLLNKLKAYKLQEQGRDTVEANLELG 329

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHY 182
           F  D+RD+   A + + L ++++RL+TNNP K   L   G+ I E VP+ +  NP+N  Y
Sbjct: 330 FKMDQRDYGTGAQILRDLNISKLRLITNNPVKRAALAGYGLEITEAVPIEIPSNPHNLEY 389

Query: 183 LDTKAEKMGHLLNK 196
           L TK +KMGH + K
Sbjct: 390 LKTKRDKMGHTILK 403


>UniRef50_O84736 GTP cyclohydrolase-2 n=38 Tax=Bacteria RepID=RIBBA_CHLTR
          Length = 424

 Score =  195 bits (496), Expect = 5e-49,   Method: Compositional matrix adjust.
 Identities = 100/194 (51%), Positives = 132/194 (68%), Gaps = 1/194 (0%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           + +++ A+LPT +GDF +  +E +  G  H ALV GDI     V  RVHSECLTGD L S
Sbjct: 211 VTKISSARLPTKYGDFSIHVYESIIDGTQHFALVKGDIHEQEAVPVRVHSECLTGDILGS 270

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
            RCDCG QL+ A+  IAEEG G+++Y R QEGR IG  +KIRAYALQD GYDTV+AN QL
Sbjct: 271 CRCDCGAQLDMAMRYIAEEGLGVIVYLRGQEGRGIGFGHKIRAYALQDLGYDTVDANLQL 330

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181
           GF  D R++ + A + K L +  VRL+T+NP+K   L   GI++++R+ L V  +  NE 
Sbjct: 331 GFPIDAREYGMAAQVLKDLQLTSVRLITHNPRKFFELQRLGIHVLDRIILPVSISTENEG 390

Query: 182 YLDTKAEKMGHLLN 195
           YL TK E+MGH L+
Sbjct: 391 YLRTKKERMGHWLD 404


>UniRef50_Q4FV65 GTP cyclohydrolase-2 n=3 Tax=Psychrobacter RepID=Q4FV65_PSYA2
          Length = 230

 Score =  195 bits (496), Expect = 7e-49,   Method: Compositional matrix adjust.
 Identities = 108/220 (49%), Positives = 133/220 (60%), Gaps = 26/220 (11%)

Query: 1   MQLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYG-------DISGHTPV------- 46
           M  + +  AKLPT  G+F +  FE    G +HV L  G       D +   P        
Sbjct: 1   MSYQFITSAKLPTRHGEFDIHIFEN-DEGQEHVMLTVGLPVVDQTDTTDSLPSPDTILNQ 59

Query: 47  -----------LARVHSECLTGDALFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRN 95
                      L R+HSECLTGDA  SL+CDCG QL  A+  I E G G +LY RQEGR 
Sbjct: 60  EDNALSERPIPLIRIHSECLTGDAFSSLKCDCGPQLNTAMHAIQETGCGAILYLRQEGRG 119

Query: 96  IGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKV 155
           IGL NKIRAYALQDQG+DT++AN  LG  AD R + +C  M   +GV+ VRL+TNNP KV
Sbjct: 120 IGLTNKIRAYALQDQGHDTLDANLMLGLPADARIYDMCGPMLAHIGVDAVRLITNNPSKV 179

Query: 156 EILTEAGINIVERVPLIVGRNPNNEHYLDTKAEKMGHLLN 195
             LTE GI+++ERVPL+VG N  N  YL TK ++MGHLL+
Sbjct: 180 AYLTEHGIDVIERVPLVVGVNDMNAEYLATKRDRMGHLLD 219


>UniRef50_A1T8K1 GTP cyclohydrolase-2 n=43 Tax=cellular organisms RepID=RIBBA_MYCVP
          Length = 423

 Score =  193 bits (491), Expect = 2e-48,   Method: Compositional matrix adjust.
 Identities = 107/198 (54%), Positives = 134/198 (67%), Gaps = 5/198 (2%)

Query: 2   QLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISG-HTP---VLARVHSECLTG 57
            + RVAEA++PT  G+F  VG+  +    +HVALV G+ISG H+    VL RVHSECLTG
Sbjct: 208 HIARVAEARIPTRHGEFRAVGYTSIYEDVEHVALVKGEISGPHSDGHDVLVRVHSECLTG 267

Query: 58  DALFSLRCDCGFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVE 116
           D   S RCDCG QL+AAL  +A EGRG++LY R  EGR IGL++K++AY LQD G DTV+
Sbjct: 268 DVFGSRRCDCGPQLDAALAMVAREGRGVVLYMRGHEGRGIGLMHKLQAYQLQDAGDDTVD 327

Query: 117 ANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRN 176
           AN +LG  AD RD+   A +   LGV  +RLLTNNP K   L   G++I+ERVPL V  N
Sbjct: 328 ANLKLGLPADARDYGTGAQILVDLGVRSMRLLTNNPAKRVGLDGYGLHIIERVPLPVRAN 387

Query: 177 PNNEHYLDTKAEKMGHLL 194
             N  YL TK ++MGH L
Sbjct: 388 AENIRYLMTKRDRMGHDL 405


>UniRef50_B8JBX2 GTP cyclohydrolase-2 n=5 Tax=Bacteria RepID=B8JBX2_ANAD2
          Length = 248

 Score =  193 bits (490), Expect = 3e-48,   Method: Compositional matrix adjust.
 Identities = 97/185 (52%), Positives = 124/185 (67%)

Query: 11  LPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQ 70
           LPT  G F +V F       +HVALV+GD+ G   V  R+HSECLTGD + SLRCDC  Q
Sbjct: 38  LPTRAGPFRIVAFWNNRDAKEHVALVHGDVVGAADVPVRLHSECLTGDVMGSLRCDCRDQ 97

Query: 71  LEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDF 130
           L   L  I  EGRG+LLY RQEGR IGL+NKIRAYALQ+QG DTVEAN  LGF  DERD+
Sbjct: 98  LTEGLAAIQREGRGVLLYLRQEGRGIGLINKIRAYALQEQGLDTVEANLALGFRDDERDY 157

Query: 131 TLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAEKM 190
            + A M   L +  +RL+TNNP+K+  LT   +++  R+P ++    +N  YL+TKA + 
Sbjct: 158 AVAAHMIHGLELRSIRLITNNPEKIRQLTAYRVDVSGRIPHVIPPGEHNRFYLETKARRS 217

Query: 191 GHLLN 195
           GHL++
Sbjct: 218 GHLID 222


>UniRef50_Q1IPQ1 GTP cyclohydrolase-2 n=4 Tax=Bacteria RepID=Q1IPQ1_ACIBL
          Length = 224

 Score =  193 bits (490), Expect = 3e-48,   Method: Compositional matrix adjust.
 Identities = 101/210 (48%), Positives = 132/210 (62%), Gaps = 21/210 (10%)

Query: 5   RVAEAKLPTPWGDFLMVGFE-------ELATGHD-------------HVALVYGDISGHT 44
           ++AEA  PT WG F + GFE       + A+ +D              VALV GDI    
Sbjct: 15  KMAEADFPTRWGRFRIYGFEGTFEEVPDSASANDLARDGVIERRKESAVALVMGDIHSQP 74

Query: 45  PVLARVHSECLTGDALFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRA 104
           P L R+HS+CLTGD   S RCDC  QLE AL  I++ G G+L+Y  QEGR IGL+ K++A
Sbjct: 75  P-LVRIHSQCLTGDVFGSQRCDCRQQLELALQMISDAGNGVLIYEEQEGRGIGLMAKLQA 133

Query: 105 YALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGIN 164
           Y LQD+G DTVEAN QLG  AD R +TL  ++ K LG+  +RLL+NNP+KV+ + +AGI 
Sbjct: 134 YELQDKGLDTVEANEQLGLKADYRQYTLPVEIMKALGITRLRLLSNNPEKVKAVEDAGIE 193

Query: 165 IVERVPLIVGRNPNNEHYLDTKAEKMGHLL 194
           +VERV   V   P ++ YL TK +KMGH+ 
Sbjct: 194 VVERVSAEVEAYPTSKAYLQTKKDKMGHIF 223


>UniRef50_A0PPL6 GTP cyclohydrolase-2 n=82 Tax=Bacteria RepID=RIBBA_MYCUA
          Length = 425

 Score =  193 bits (490), Expect = 3e-48,   Method: Compositional matrix adjust.
 Identities = 103/199 (51%), Positives = 133/199 (66%), Gaps = 5/199 (2%)

Query: 2   QLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTP----VLARVHSECLTG 57
            ++RVAEA++PT  G+F  +G+  +    +HVALV G+I+G       VL RVHSECLTG
Sbjct: 208 HIERVAEARIPTRRGEFRAIGYTSIYENVEHVALVRGEIAGPNSDGDDVLVRVHSECLTG 267

Query: 58  DALFSLRCDCGFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVE 116
           D   S RCDCG QL+AA+  +A EGRG++LY R  EGR IGLL+K++ Y LQD G DTV+
Sbjct: 268 DVFGSRRCDCGSQLDAAMAMVAREGRGVVLYMRGHEGRGIGLLHKLQTYQLQDAGDDTVD 327

Query: 117 ANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRN 176
           AN +LG  AD RD+ + A +   LGV  +RLLTNNP K   L   G++I+ERVPL V  N
Sbjct: 328 ANLKLGLPADARDYGIGAQILVDLGVRSMRLLTNNPAKRVGLDGYGLHIIERVPLPVRAN 387

Query: 177 PNNEHYLDTKAEKMGHLLN 195
             N  YL TK ++MGH L 
Sbjct: 388 AENIRYLMTKRDRMGHDLT 406


>UniRef50_C9KJZ5 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
           n=1 Tax=Mitsuokella multacida DSM 20544
           RepID=C9KJZ5_9FIRM
          Length = 403

 Score =  192 bits (488), Expect = 5e-48,   Method: Compositional matrix adjust.
 Identities = 99/190 (52%), Positives = 124/190 (65%)

Query: 6   VAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRC 65
           VA+   P+ +G F +  +E        +A+V GD+ G   VL RVHSECLTGDAL S+RC
Sbjct: 209 VADVDFPSKYGHFRIHAYENELNNKCDIAIVKGDVRGKKDVLVRVHSECLTGDALGSMRC 268

Query: 66  DCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAA 125
           DCG QL  AL +I  EG G++LY RQEGR IGL NK+RAYALQD+G DTVEAN +LGFA 
Sbjct: 269 DCGDQLALALKKIEAEGEGVVLYMRQEGRGIGLANKMRAYALQDKGRDTVEANVELGFAP 328

Query: 126 DERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDT 185
           D RD+ + A +   LG+  +RL+TNNP K   L   G+ I  RVPL V  N  ++ YL  
Sbjct: 329 DLRDYGIGAQILADLGLTSIRLMTNNPAKRAGLEGYGLEITGRVPLQVHANKFDKRYLTV 388

Query: 186 KAEKMGHLLN 195
           K  KMGHL +
Sbjct: 389 KKVKMGHLFS 398


>UniRef50_Q1D4N5 GTP cyclohydrolase-2 n=6 Tax=Cystobacterineae RepID=Q1D4N5_MYXXD
          Length = 224

 Score =  192 bits (487), Expect = 7e-48,   Method: Compositional matrix adjust.
 Identities = 95/192 (49%), Positives = 125/192 (65%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           L+R +EA +PT  G    + F +   G +HVALV G +SGH  V  R+HSECLT +   S
Sbjct: 19  LERFSEADIPTERGSLRTIVFRDKRNGREHVALVVGQVSGHEGVPVRIHSECLTSEVFGS 78

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
           L+CDC  QL+ +L  I + G+G++LY RQEGR IGL NKI+AYALQ +G DT EAN QLG
Sbjct: 79  LKCDCREQLDRSLDFITQAGQGVVLYLRQEGRGIGLGNKIKAYALQSKGLDTYEANRQLG 138

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHY 182
           FA D R + + A+M + L V  V L+TNNP K+  + E GI +  R+P     NP+N  Y
Sbjct: 139 FADDLRTYDIAAEMLRSLDVRSVDLMTNNPLKIAGMVEEGIPVRRRIPSRTEHNPHNVDY 198

Query: 183 LDTKAEKMGHLL 194
           L TK E+ GHL+
Sbjct: 199 LRTKRERTGHLI 210


>UniRef50_D0LLG6 GTP cyclohydrolase-2 n=1 Tax=Haliangium ochraceum DSM 14365
           RepID=D0LLG6_HALO1
          Length = 214

 Score =  191 bits (484), Expect = 1e-47,   Method: Compositional matrix adjust.
 Identities = 97/192 (50%), Positives = 127/192 (66%)

Query: 1   MQLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDAL 60
           + L++ A +KLPT  G F +  +       + +A+  G  +   P   RVHSEC TG+ L
Sbjct: 12  VSLEKYATSKLPTIHGQFEVTVYRYGPDSEEALAVTLGSFAPDEPTFVRVHSECYTGEVL 71

Query: 61  FSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQ 120
            SL+CDC  QLE ALT+I E GRG+L+Y RQEGR IGL NKIRAYALQDQG DTV+ANHQ
Sbjct: 72  GSLKCDCREQLELALTRIQELGRGVLVYLRQEGRGIGLGNKIRAYALQDQGADTVQANHQ 131

Query: 121 LGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNE 180
           LGFA D R+F + A++ K LGV  + L TNNP+K++ + + GI +V R P     NP+N 
Sbjct: 132 LGFATDLREFDVAAEILKDLGVARIHLHTNNPEKIQAMEDHGIELVSREPAHGVINPHNR 191

Query: 181 HYLDTKAEKMGH 192
            YL+TK   +GH
Sbjct: 192 RYLETKHHTLGH 203


>UniRef50_A5G2C3 GTP cyclohydrolase-2 n=2 Tax=Rhodospirillales RepID=A5G2C3_ACICJ
          Length = 384

 Score =  191 bits (484), Expect = 2e-47,   Method: Compositional matrix adjust.
 Identities = 101/196 (51%), Positives = 134/196 (68%), Gaps = 5/196 (2%)

Query: 3   LKRVAEAKLP---TPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDA 59
           L RVAE  +P    P  D  +V F  L  G +H+A++ GD S     L R+HSEC TGD 
Sbjct: 191 LHRVAEVAVPLDDAP--DARLVAFRALDQGIEHMAILVGDPSAQAAPLVRIHSECFTGDL 248

Query: 60  LFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANH 119
           L SLRCDCG QL+ A+ ++A+EG G++LY  QEGR IGL+NK+RAY LQD+G DTV+AN 
Sbjct: 249 LGSLRCDCGPQLKGAIRRMAQEGGGVVLYLAQEGRGIGLINKLRAYTLQDRGLDTVDANR 308

Query: 120 QLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNN 179
            LG+ ADER+F + A M   LG++ +RLLTNNP+K   L   G+++VERVP ++  N  N
Sbjct: 309 ALGWGADERNFHIAAAMLAALGLDHIRLLTNNPEKTAGLAACGVDVVERVPHVIAPNGVN 368

Query: 180 EHYLDTKAEKMGHLLN 195
           + YL TKA + GHLL+
Sbjct: 369 DLYLATKARRFGHLLD 384


>UniRef50_C5CJ14 GTP cyclohydrolase II n=1 Tax=Kosmotoga olearia TBF 19.5.1
           RepID=C5CJ14_KOSOT
          Length = 390

 Score =  190 bits (483), Expect = 2e-47,   Method: Compositional matrix adjust.
 Identities = 103/191 (53%), Positives = 126/191 (65%), Gaps = 3/191 (1%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           +K V+ A LPT +G F +V FE      +H A++YGDIS   PV  R+HSECLTGDAL S
Sbjct: 194 VKVVSIASLPTKFGTFQIVSFENNYDFLEHTAIIYGDISKE-PVPVRIHSECLTGDALGS 252

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
           LRCDCG QL+ A+  I  +GRGI+LY RQEGR IGL NKI+AY LQD G DTV+AN  LG
Sbjct: 253 LRCDCGSQLQNAMRYIKSQGRGIVLYLRQEGRGIGLHNKIKAYHLQDNGMDTVDANIALG 312

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGR-NPNNEH 181
           F  D RD+ + A M + LGV ++ LL+NNP K+  L    I IV+    I G   P N  
Sbjct: 313 FPEDMRDYGVAAQMLRALGVKKIILLSNNPDKLRQLKHYQI-IVDETRNIFGEITPYNHF 371

Query: 182 YLDTKAEKMGH 192
           YL TK E+MGH
Sbjct: 372 YLKTKMERMGH 382


>UniRef50_B9L8K1 GTP cyclohydrolase-2 n=3 Tax=Bacteria RepID=B9L8K1_NAUPA
          Length = 185

 Score =  189 bits (479), Expect = 6e-47,   Method: Compositional matrix adjust.
 Identities = 101/186 (54%), Positives = 127/186 (68%), Gaps = 7/186 (3%)

Query: 9   AKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCG 68
           A LPT +G F +  F+E     +H+A ++ +     P + R+HSECLTGDAL SL+CDCG
Sbjct: 7   ATLPTKYGIFKIQSFKE--NDKEHLA-IFTEKLPEIPYI-RIHSECLTGDALGSLKCDCG 62

Query: 69  FQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADER 128
            QL  AL  I E G GI+LY RQEGR IGL NK+ AYALQD+G DTVEANHQLGF AD R
Sbjct: 63  DQLAFALKTINEHG-GIVLYLRQEGRGIGLFNKVNAYALQDKGLDTVEANHQLGFEADMR 121

Query: 129 DFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAE 188
           DF++   + K  G+ +++LLTNNPKK        I +VER+P+ V  NP NE+YL TK E
Sbjct: 122 DFSIVEKILKHFGIKQIKLLTNNPKKE--FAFKNIKVVERIPVKVEPNPYNENYLKTKKE 179

Query: 189 KMGHLL 194
           K+GH L
Sbjct: 180 KLGHKL 185


>UniRef50_Q13NP8 GTP cyclohydrolase-2 n=9 Tax=cellular organisms RepID=Q13NP8_BURXL
          Length = 224

 Score =  188 bits (478), Expect = 8e-47,   Method: Compositional matrix adjust.
 Identities = 98/191 (51%), Positives = 124/191 (64%), Gaps = 1/191 (0%)

Query: 7   AEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCD 66
           A A LPT +G F    F    +G +H+ALV GD++  + VL R+HSECLTGD L S RCD
Sbjct: 32  ATATLPTRYGTFTSYVFRVCESGAEHLALVMGDVANKSSVLTRLHSECLTGDVLGSYRCD 91

Query: 67  CGFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAA 125
           CG QL+ AL  IA EG G+LLY R  EGR IGL NKIRAYALQ+QG DTVEAN  LG   
Sbjct: 92  CGEQLDLALRYIAAEGCGVLLYLRGHEGRGIGLSNKIRAYALQEQGRDTVEANLDLGLPD 151

Query: 126 DERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDT 185
           D R++   A + + L V  VRL++NNP+K + L++ GI + ERV L +     NE Y+ T
Sbjct: 152 DSREYDSAAGILRTLKVTSVRLMSNNPEKFDTLSKHGIPVCERVALAIPMREENERYIRT 211

Query: 186 KAEKMGHLLNK 196
           K  K GH  ++
Sbjct: 212 KQVKFGHYFDE 222


>UniRef50_C7NTK7 GTP cyclohydrolase II n=1 Tax=Halorhabdus utahensis DSM 12940
           RepID=C7NTK7_HALUD
          Length = 412

 Score =  185 bits (470), Expect = 7e-46,   Method: Compositional matrix adjust.
 Identities = 102/195 (52%), Positives = 130/195 (66%), Gaps = 6/195 (3%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALV-YGDISGHTP-VLARVHSECLTGDAL 60
           + R  + +LPT +G F M G++    G  HVALV   D+   T   L R+HS+CLTGDAL
Sbjct: 217 VSREVDTRLPTAFGTFDMYGYD--YRGETHVALVNLDDVDPETDRPLVRIHSKCLTGDAL 274

Query: 61  FSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQ 120
            SL+CDCGFQLE  + +I++EG G+LLY  QEGR IGLLNK++AY LQ+ GYDTVEAN +
Sbjct: 275 HSLKCDCGFQLEETMQRISDEG-GVLLYLDQEGRGIGLLNKLKAYELQEHGYDTVEANVE 333

Query: 121 LGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNE 180
           LGF  DER F   A M + +G++ VRLLTNNP+K   L     + VE   L +  NP NE
Sbjct: 334 LGFEPDERRFDAAAQMLRDIGLDRVRLLTNNPRKAAALERFEFD-VEIDSLEIEPNPENE 392

Query: 181 HYLDTKAEKMGHLLN 195
            YL TKAEK+ H L+
Sbjct: 393 AYLATKAEKLDHQLD 407


>UniRef50_B0RC63 Riboflavin biosynthesis protein RibA n=7 Tax=Actinomycetales
           RepID=B0RC63_CLAMS
          Length = 453

 Score =  184 bits (466), Expect = 2e-45,   Method: Compositional matrix adjust.
 Identities = 93/186 (50%), Positives = 128/186 (68%), Gaps = 3/186 (1%)

Query: 8   EAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDC 67
           E  +PT  G   +  + +  TG DHVA+V G+   H   L RVHSECLTG+AL SL+C+C
Sbjct: 225 ETTVPTTHGSVKLRAYRDRTTGADHVAIVAGEPRAHG-TLVRVHSECLTGEALGSLKCEC 283

Query: 68  GFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAAD 126
           G QL+AAL +I  +G G+++Y R  EGR IGL+NK+RAY LQ+ G+DT++AN  LG  AD
Sbjct: 284 GPQLDAALDEIQRDG-GVVVYLRGHEGRGIGLINKLRAYRLQEDGFDTLDANVALGLPAD 342

Query: 127 ERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTK 186
            RD+   + + + +G+ +VRLLTNNP+KV  L   G+ + ERVPL+VG N  N  YL+TK
Sbjct: 343 ARDYGAASAILQEMGIEDVRLLTNNPEKVRQLEAHGVEVTERVPLVVGVNEVNAGYLETK 402

Query: 187 AEKMGH 192
            ++MGH
Sbjct: 403 RDRMGH 408


>UniRef50_D2R1R5 GTP cyclohydrolase II n=3 Tax=Planctomycetaceae RepID=D2R1R5_9PLAN
          Length = 403

 Score =  183 bits (465), Expect = 2e-45,   Method: Compositional matrix adjust.
 Identities = 94/195 (48%), Positives = 130/195 (66%), Gaps = 3/195 (1%)

Query: 3   LKRVAEAKLPT-PWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALF 61
           + R+A+A++PT  +GDF ++ +E        V LV GD++     L R+HS C TGD L 
Sbjct: 206 VTRIAQAQIPTGQFGDFTIIAYEVKFETQTPVVLVKGDLTSVEAPLVRLHSSCFTGDLLD 265

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
           SLRCDCG QL+ AL  I +E  G+L+Y  QEGR IGL+ KI+AY LQ++G DTVEAN  L
Sbjct: 266 SLRCDCGDQLKKALEMIRDEKVGVLVYLPQEGRGIGLVEKIKAYDLQERGLDTVEANTAL 325

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAG--INIVERVPLIVGRNPNN 179
           G+ AD RD+ +   + K LG+++VRL+TNNPKK +     G  + +V++VP+I   NP+N
Sbjct: 326 GYKADMRDYGVGIQILKDLGLSKVRLMTNNPKKTDAFIYGGFSLEVVDQVPIITESNPHN 385

Query: 180 EHYLDTKAEKMGHLL 194
             YL TK +KMGH L
Sbjct: 386 AKYLATKRDKMGHKL 400


>UniRef50_A6C5C2 Riboflavin biosynthesis protein RibA n=1 Tax=Planctomyces maris DSM
           8797 RepID=A6C5C2_9PLAN
          Length = 416

 Score =  182 bits (463), Expect = 4e-45,   Method: Compositional matrix adjust.
 Identities = 92/182 (50%), Positives = 120/182 (65%), Gaps = 2/182 (1%)

Query: 15  WGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAA 74
           +G   ++G+         VALV+GD+      L R+HS C TGD L SLRCDCG QL  A
Sbjct: 229 YGTVQVIGYSVEHESQQPVALVWGDLHSVEAPLVRMHSSCFTGDLLDSLRCDCGDQLHMA 288

Query: 75  LTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCA 134
           ++ I + G G ++Y  QEGR IGL+ K++AY LQDQGYDTVEAN QLGF AD RDFT+  
Sbjct: 289 MSAINQAGAGAVVYLPQEGRGIGLIPKLKAYVLQDQGYDTVEANIQLGFKADSRDFTVGV 348

Query: 135 DMFKLLGVNEVRLLTNNPKKVEILTEAGIN--IVERVPLIVGRNPNNEHYLDTKAEKMGH 192
            + K LG+ +VRLLTNNPKK +     G N  +VE+VP++   + + E YL TK +KMGH
Sbjct: 349 QILKDLGLTKVRLLTNNPKKTDSDVYTGFNLEVVEQVPIVAPPHKDREFYLQTKRDKMGH 408

Query: 193 LL 194
           +L
Sbjct: 409 IL 410


>UniRef50_D2RDK3 GTP cyclohydrolase II n=2 Tax=Archaeoglobaceae RepID=D2RDK3_ARCPR
          Length = 376

 Score =  182 bits (462), Expect = 5e-45,   Method: Compositional matrix adjust.
 Identities = 99/194 (51%), Positives = 130/194 (67%), Gaps = 6/194 (3%)

Query: 3   LKRVAEAKLPTP-WGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALF 61
           ++RV  A LPT  +G F  VG++      + VALV G++S    VL R+HSECLTGD   
Sbjct: 183 VERVVSATLPTKFYGTFKAVGYK--TPLGEIVALVKGNVS-EGDVLVRIHSECLTGDVFH 239

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVEANHQ 120
           SLRCDCG QLE AL +I EEG+G+L+Y R  EGR IGL+NK+ AY LQ++G DTVEAN +
Sbjct: 240 SLRCDCGEQLERALKKIDEEGKGVLIYMRGHEGRGIGLINKLMAYKLQEEGKDTVEANVE 299

Query: 121 LGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNE 180
           LGF  D R + + A +   LGV  VRL+TNNP K+E L + G  +V R P+++     N+
Sbjct: 300 LGFPPDLRSYGIAAQILMDLGVKSVRLMTNNPNKIEELKKYGFKVV-REPIVIEPVEENK 358

Query: 181 HYLDTKAEKMGHLL 194
            YL TK EKMGH++
Sbjct: 359 KYLKTKMEKMGHMI 372


>UniRef50_P47924 GTP cyclohydrolase-2 n=36 Tax=cellular organisms RepID=RIBBA_ARATH
          Length = 543

 Score =  180 bits (457), Expect = 2e-44,   Method: Compositional matrix adjust.
 Identities = 91/192 (47%), Positives = 123/192 (64%), Gaps = 1/192 (0%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           ++R + A++PT WG F    +  +  G +H+A+V G+I     +L RVHSECLTGD   S
Sbjct: 333 VERASAARIPTMWGPFTAYCYRSILDGIEHIAMVKGEIGDGQDILVRVHSECLTGDIFGS 392

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
            RCDCG QL  ++ QI   GRG+L+Y R  EGR IGL +K+RAY LQD G DTVEAN +L
Sbjct: 393 ARCDCGNQLALSMQQIEATGRGVLVYLRGHEGRGIGLGHKLRAYNLQDAGRDTVEANEEL 452

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181
           G   D R++ + A + + LGV  ++L+TNNP K   L   G+ IV RVPL+      N+ 
Sbjct: 453 GLPVDSREYGIGAQIIRDLGVRTMKLMTNNPAKYVGLKGYGLAIVGRVPLLSLITKENKR 512

Query: 182 YLDTKAEKMGHL 193
           YL+TK  KMGH+
Sbjct: 513 YLETKRTKMGHM 524


>UniRef50_A6G7P6 GTP cyclohydrolase-2 n=1 Tax=Plesiocystis pacifica SIR-1
           RepID=A6G7P6_9DELT
          Length = 194

 Score =  180 bits (457), Expect = 2e-44,   Method: Compositional matrix adjust.
 Identities = 94/189 (49%), Positives = 118/189 (62%), Gaps = 1/189 (0%)

Query: 7   AEAKLPTPWGDFLMVGFEELATGH-DHVALVYGDISGHTPVLARVHSECLTGDALFSLRC 65
           A AKLP+  GD  +V F        D +A++ GDI+G + V  RVHSECLTGD   SLRC
Sbjct: 6   ARAKLPSRHGDLEIVSFTTRDGQRIDDIAIIAGDITGKSAVPTRVHSECLTGDVFGSLRC 65

Query: 66  DCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAA 125
           DC  QLE A+ +I  EG G+++Y RQEGR IG+  K+RAY LQD G DT+EAN  LGF  
Sbjct: 66  DCRDQLELAIDRICSEGVGLIVYMRQEGRGIGIAEKVRAYELQDSGLDTLEANVHLGFDG 125

Query: 126 DERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDT 185
           D R + + A M + L V+ V L TNNP+KVE L   G+ +  R  +I      N HYL T
Sbjct: 126 DLRSYEVAASMIQALEVDSVVLFTNNPEKVEGLQANGVEVERREAIISESREENVHYLMT 185

Query: 186 KAEKMGHLL 194
           K  KMGH+L
Sbjct: 186 KKAKMGHIL 194


>UniRef50_C9MTM9 GTP cyclohydrolase-2 n=1 Tax=Prevotella veroralis F0319
           RepID=C9MTM9_9BACT
          Length = 205

 Score =  180 bits (456), Expect = 3e-44,   Method: Compositional matrix adjust.
 Identities = 90/186 (48%), Positives = 126/186 (67%), Gaps = 3/186 (1%)

Query: 11  LPTPWGDFLMVGFEELATGHDHVALVYGDI--SGHTPVLARVHSECLTGDALFSLRCDCG 68
           +PT WGDF M+ F     G D   +  G++  S + P++ R+HS C +GD L SLRCDCG
Sbjct: 14  MPTIWGDFFMIPFHNEDDGKDCFVVGKGNVLNSVNIPIV-RIHSSCSSGDILGSLRCDCG 72

Query: 69  FQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADER 128
            QL  AL  I ++G G+L+Y  QEGR IGL++K++AY LQ+QG DTV+AN Q+G + DER
Sbjct: 73  EQLHKALKLIEQKGEGLLIYLNQEGRGIGLMDKMKAYKLQEQGVDTVDANLQIGHSVDER 132

Query: 129 DFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAE 188
           D+ + A + KLLG++E+ LLTNN  K + L   GIN+ + +PL    N  N+ YL+TK +
Sbjct: 133 DYAIGAAILKLLGISEIDLLTNNLLKSQGLIRNGINVRKIIPLETSPNKYNKFYLETKKK 192

Query: 189 KMGHLL 194
           +MGHLL
Sbjct: 193 RMGHLL 198


>UniRef50_C7JCF3 Bifunctional protein 3,4-dihydroxy-2-butanone 4-phosphate
           synthase/GTP cyclohydrolase II n=8 Tax=Acetobacter
           pasteurianus RepID=C7JCF3_ACEP3
          Length = 437

 Score =  179 bits (455), Expect = 4e-44,   Method: Compositional matrix adjust.
 Identities = 99/195 (50%), Positives = 128/195 (65%), Gaps = 5/195 (2%)

Query: 6   VAEAKLPTPWG-DFLMVGFEELATGHDHVALVYGDI--SGHTPVLARVHSECLTGDALFS 62
           +A+A LP+ +G D L++   +   G +HVALV GD+   G  P L R+HSEC+TGDAL S
Sbjct: 232 LAQASLPSAYGGDDLVIHAYQDENGVEHVALVKGDVRRKGAVP-LVRLHSECVTGDALGS 290

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
           LRCDCG QL AAL  I +   G+L+Y R  EGR IGL+NKIRAY LQD G DTV+ANH+L
Sbjct: 291 LRCDCGSQLHAALRAIGKAECGVLVYVRGHEGRGIGLVNKIRAYELQDAGLDTVDANHRL 350

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181
           GFA D RD+   + + + LGV E+ LLTNNP KV  L   G  +  R+ L +   P+N  
Sbjct: 351 GFATDARDWRAASGILRSLGVGELDLLTNNPDKVRALEARGFMVRRRIGLEIPPTPHNRA 410

Query: 182 YLDTKAEKMGHLLNK 196
           YL+ K  +MGH L +
Sbjct: 411 YLEAKRRRMGHHLGQ 425


>UniRef50_B9HF78 Predicted protein (Fragment) n=10 Tax=cellular organisms
           RepID=B9HF78_POPTR
          Length = 449

 Score =  179 bits (453), Expect = 5e-44,   Method: Compositional matrix adjust.
 Identities = 92/188 (48%), Positives = 119/188 (63%), Gaps = 1/188 (0%)

Query: 7   AEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCD 66
           A A +PT WG F    +  L  G +H+A+V G+I     +L RVHSECLTGD   S RCD
Sbjct: 252 AAAPIPTMWGPFKAYCYRSLLDGIEHIAMVKGEIGDGKDILVRVHSECLTGDIFGSARCD 311

Query: 67  CGFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAA 125
           CG QL  A+ QI   GRG+L+Y R  EGR IGL +K+RAY LQD G DTVEAN +LG   
Sbjct: 312 CGKQLALAMKQIEAAGRGVLVYLRGHEGRGIGLGHKLRAYNLQDDGRDTVEANEELGLPV 371

Query: 126 DERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDT 185
           D R++ + A + + LGV+ ++L+TNNP K   L   G+ +  RVPL+      N  YL+T
Sbjct: 372 DSREYGIGAQILRDLGVHTMKLMTNNPAKYVGLKGYGLAVAGRVPLLTPITMENRRYLET 431

Query: 186 KAEKMGHL 193
           K EKMGH+
Sbjct: 432 KREKMGHV 439


>UniRef50_Q9X2E6 GTP cyclohydrolase-2 n=13 Tax=cellular organisms RepID=RIBBA_THEMA
          Length = 388

 Score =  179 bits (453), Expect = 7e-44,   Method: Compositional matrix adjust.
 Identities = 98/194 (50%), Positives = 123/194 (63%), Gaps = 3/194 (1%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           +K+ AEA LPT +G F +V FE    G +H A+V   +    PV  R+HSEC+TGD L S
Sbjct: 191 MKKKAEATLPTDFGVFKVVSFENHLDGKEHFAIVKEPL--EDPVAVRIHSECVTGDVLSS 248

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
           LRCDCG QL   L  ++  G GIL+Y RQEGR IGL NKI AY+LQD+G DTVEAN  LG
Sbjct: 249 LRCDCGSQLANFLRYMSAHG-GILIYLRQEGRGIGLSNKIAAYSLQDKGLDTVEANRVLG 307

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHY 182
           F+ DERD+   A + K LG+  V L TNN +K   L + GI +VE   L     P+N  Y
Sbjct: 308 FSEDERDYAPAAQILKALGIERVLLFTNNQRKTVGLEKYGIEVVETKRLYGRVTPHNRFY 367

Query: 183 LDTKAEKMGHLLNK 196
           L TK +K+GH L +
Sbjct: 368 LSTKMKKLGHELEE 381


>UniRef50_Q7VK48 GTP cyclohydrolase-2 n=2 Tax=Helicobacteraceae RepID=RIBA_HELHP
          Length = 194

 Score =  177 bits (448), Expect = 2e-43,   Method: Compositional matrix adjust.
 Identities = 96/198 (48%), Positives = 127/198 (64%), Gaps = 8/198 (4%)

Query: 1   MQLKRVAEAKLPTPWGDFLMVGFEELA---TGHDHVALVYGDISGHTPVLARVHSECLTG 57
           M+ +   +AKLPT +G+F    F E     T  +H+ +V+    G TP L R+HSECLTG
Sbjct: 1   MKYEISEQAKLPTRFGNFFTKSFREYGKNNTLFEHL-VVFTHTLGETP-LVRIHSECLTG 58

Query: 58  DALFSLRCDCGFQLEAALTQIAEEGRG-ILLYHRQEGRNIGLLNKIRAYALQDQGYDTVE 116
           D   S +CDCG +L  A+ QIA    G +L+Y RQEGR IGL NKI AYALQD+GYDTVE
Sbjct: 59  DVFGSKKCDCGNELALAMEQIAHNTEGGMLIYLRQEGRGIGLFNKINAYALQDKGYDTVE 118

Query: 117 ANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRN 176
           AN QLGFA D R + +  ++FK   +  + LLTNNP+K++ L  A    V R  +I   N
Sbjct: 119 ANQQLGFAGDMRSYEIVGEIFKHFHITHINLLTNNPRKIDAL--APYAKVVRHSIITPSN 176

Query: 177 PNNEHYLDTKAEKMGHLL 194
           P+N+ YL+ K +K+GHLL
Sbjct: 177 PHNQAYLEVKKQKLGHLL 194


>UniRef50_A0RR75 GTP cyclohydrolase-2 n=10 Tax=Epsilonproteobacteria
           RepID=RIBA_CAMFF
          Length = 195

 Score =  177 bits (448), Expect = 2e-43,   Method: Compositional matrix adjust.
 Identities = 91/196 (46%), Positives = 130/196 (66%), Gaps = 4/196 (2%)

Query: 1   MQLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDAL 60
           M++ +   A LP+ +G F +  ++E     +H+ +   ++     V  R+HSECLTGDA+
Sbjct: 1   MEIIKSNIANLPSRFGKFQIKSYKE-GCCKEHLTIFSPNLDVTKTVNVRIHSECLTGDAI 59

Query: 61  FSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQ 120
            SL+CDC  QLEA+L  I + G G+++Y RQEGRNIGLLNK+ AYALQD G DT+EANHQ
Sbjct: 60  GSLKCDCRDQLEASLKYINKHG-GMVIYLRQEGRNIGLLNKVNAYALQDNGLDTIEANHQ 118

Query: 121 LGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNE 180
           LGF ADER + +   + K  G+  + LLTNNP K+  LT   +NI +R+P+ +  N  N+
Sbjct: 119 LGFKADERTYEIVDFILKDFGIKSINLLTNNPLKLASLT--CVNIEKRIPIEIESNEFNK 176

Query: 181 HYLDTKAEKMGHLLNK 196
            YL  K E+MGH+L++
Sbjct: 177 DYLKVKKEQMGHMLDE 192


>UniRef50_D1IKX7 Whole genome shotgun sequence of line PN40024,
           scaffold_17.assembly12x (Fragment) n=19 Tax=cellular
           organisms RepID=D1IKX7_VITVI
          Length = 845

 Score =  176 bits (447), Expect = 3e-43,   Method: Compositional matrix adjust.
 Identities = 90/192 (46%), Positives = 120/192 (62%), Gaps = 1/192 (0%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           + R A A++PT WG F    +  +  G +H+A+V G+I     +L RVHSECLTGD   S
Sbjct: 623 VDRSAGARIPTMWGPFTAYCYRSILDGIEHIAMVKGEIGDGQDILVRVHSECLTGDIFGS 682

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
            RCDCG QL  A+ QI + G+G+L+Y R  EGR IGL +K+ AY LQD G DTVEAN +L
Sbjct: 683 ARCDCGNQLALAMQQIEKAGKGVLVYLRGHEGRGIGLGHKLHAYNLQDDGRDTVEANEEL 742

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181
           G   D R++ + A M + LGV  ++L+TNNP K   L   G+ +  RVPL+      N  
Sbjct: 743 GLPVDSREYGIGAQMLRDLGVRTMKLMTNNPAKYIGLKGYGLAVSGRVPLLTPITKENGR 802

Query: 182 YLDTKAEKMGHL 193
           YL+TK  KMGH+
Sbjct: 803 YLETKRSKMGHV 814


>UniRef50_D1BH22 GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase
           n=4 Tax=Bacteria RepID=D1BH22_SANKS
          Length = 464

 Score =  176 bits (445), Expect = 5e-43,   Method: Compositional matrix adjust.
 Identities = 97/189 (51%), Positives = 122/189 (64%), Gaps = 3/189 (1%)

Query: 9   AKLPTPWGDFLMVGFEELATGHDHVALVYGDI--SGHTPVLARVHSECLTGDALFSLRCD 66
           A+LPT  GDF + G+ +L TG +HVALV   +      PV+ RVHSECLTGDA  SLRCD
Sbjct: 230 AELPTAHGDFRVHGYRDLRTGAEHVALVPVGVEHPEEVPVV-RVHSECLTGDAFGSLRCD 288

Query: 67  CGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAAD 126
           CG QLEA++  +A EG  ++     EGR IGLL KI AY LQD G DTV+AN  LG+ AD
Sbjct: 289 CGPQLEASMEIVAREGGAVVYLRGHEGRGIGLLAKIAAYELQDAGRDTVQANLDLGWPAD 348

Query: 127 ERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTK 186
            R++   A +   LG+  VRLLTNNP K   L   G+ + E V + VG + +NE YL TK
Sbjct: 349 RREYGGAAAILVDLGLQRVRLLTNNPAKSTGLAAHGVEVTETVRIEVGHSQHNERYLRTK 408

Query: 187 AEKMGHLLN 195
            E MGH+L+
Sbjct: 409 KELMGHVLD 417


>UniRef50_Q6GFT5 GTP cyclohydrolase-2 n=76 Tax=Bacteria RepID=RIBBA_STAAR
          Length = 393

 Score =  176 bits (445), Expect = 5e-43,   Method: Compositional matrix adjust.
 Identities = 92/188 (48%), Positives = 120/188 (63%), Gaps = 3/188 (1%)

Query: 7   AEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCD 66
           A+ K+PT +G F M GF+   T  + V L  G I  H  V  R+HS CLTGD   S RCD
Sbjct: 209 AKVKMPTDFGTFDMYGFKATYTDEEIVVLTKGAIRQHENV--RLHSACLTGDIFHSQRCD 266

Query: 67  CGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAAD 126
           CG QLE+++  I E G G+++Y  QEGR IGLLNK+RAY L +QGYDTV AN  LGF  D
Sbjct: 267 CGAQLESSMKYINEHG-GMIIYLPQEGRGIGLLNKLRAYELIEQGYDTVTANLALGFDED 325

Query: 127 ERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTK 186
            RD+ + A + K   +  + LL+NNP K E L + GI+I ER+ +IV    +N  Y++TK
Sbjct: 326 LRDYHIAAQILKYFNIEHINLLSNNPSKFEGLKQYGIDIAERIEVIVPETVHNHDYMETK 385

Query: 187 AEKMGHLL 194
             KMGHL+
Sbjct: 386 KIKMGHLI 393


>UniRef50_A9FWS8 GTP cyclohydrolase-2 n=1 Tax=Sorangium cellulosum 'So ce 56'
           RepID=A9FWS8_SORC5
          Length = 225

 Score =  176 bits (445), Expect = 5e-43,   Method: Compositional matrix adjust.
 Identities = 97/200 (48%), Positives = 120/200 (60%), Gaps = 7/200 (3%)

Query: 2   QLKRVAEAKLPTPWGDFLMVGFEELAT-------GHDHVALVYGDISGHTPVLARVHSEC 54
           QL   A+A +PT  G F M+ F    T         DHVALV GD+ G + V  RVHSEC
Sbjct: 11  QLDIRAQAPVPTKHGVFQMLVFHFGGTTSPDQGLSPDHVALVMGDVRGRSDVTLRVHSEC 70

Query: 55  LTGDALFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDT 114
           LT +   SL+CDC  QLEAA  +I   G G++LY RQEGR IGL NKIRAY LQ  G+DT
Sbjct: 71  LTSEVFGSLKCDCREQLEAAQAEIGRRGLGVVLYLRQEGRGIGLANKIRAYQLQAFGHDT 130

Query: 115 VEANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVG 174
           V+AN  LG   D R +   A M + LG+  +RLLTNNP KV+ L   G+ I  R   IV 
Sbjct: 131 VDANRILGLPDDARGYEPAAAMIEHLGIESIRLLTNNPDKVDALRALGVRIASRSAAIVP 190

Query: 175 RNPNNEHYLDTKAEKMGHLL 194
            NP +  YL+ K  +MGH++
Sbjct: 191 ANPFSAPYLEAKRLRMGHVI 210


>UniRef50_C6V5M6 GTP cyclohydrolase-2 n=2 Tax=Neorickettsia RepID=C6V5M6_NEORI
          Length = 353

 Score =  176 bits (445), Expect = 5e-43,   Method: Compositional matrix adjust.
 Identities = 97/196 (49%), Positives = 129/196 (65%), Gaps = 7/196 (3%)

Query: 3   LKRVAEAKLPTPWG-DFLMVGFEELATGHDHVALVYGD-ISGHTPVLARVHSECLTGDAL 60
           + RV+EAK+      D  MV +  +    +H A++ GD +S   P L RVHS C TGD L
Sbjct: 159 ITRVSEAKIRIRENVDSYMVCYRSIL--KEHYAIIIGDPLSSQEP-LVRVHSSCYTGDLL 215

Query: 61  FSLRCDCGFQLEAALTQIAEEGRG-ILLYHRQEGRNIGLLNKIRAYALQ-DQGYDTVEAN 118
            SL CDC  QL   + +IAE+  G I+LY  QEGR IGL NKIRAY LQ D+G DTVEAN
Sbjct: 216 GSLSCDCRDQLHDTVKKIAEDPVGGIILYLSQEGRGIGLPNKIRAYNLQEDKGLDTVEAN 275

Query: 119 HQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPN 178
           + LGF  DERDF +   + K LG+ +VRL+TNNP+K+  L+ AG+++  RVP+++  NP 
Sbjct: 276 YCLGFKDDERDFRVVKLILKDLGIQKVRLITNNPEKIRQLSSAGVDVASRVPILMRSNPY 335

Query: 179 NEHYLDTKAEKMGHLL 194
           N  YL TK+EK+GH+ 
Sbjct: 336 NRKYLQTKSEKLGHIF 351


>UniRef50_Q604R2 Riboflavin-specific deaminase/GTP cyclohydrolase II n=1
           Tax=Methylococcus capsulatus RepID=Q604R2_METCA
          Length = 355

 Score =  175 bits (444), Expect = 7e-43,   Method: Compositional matrix adjust.
 Identities = 89/150 (59%), Positives = 105/150 (70%)

Query: 46  VLARVHSECLTGDALFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAY 105
           +LARVHSECLTGD   S RCDCG QLE AL  I E   G+LLY RQEGR IGL+ K+RAY
Sbjct: 1   MLARVHSECLTGDVFGSRRCDCGEQLELALRAIGEAECGVLLYLRQEGRGIGLVQKLRAY 60

Query: 106 ALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINI 165
            LQD+G DTVEAN +LG  ADERD+ + A M + LGV  VRL+TNNPKK++ L   GI I
Sbjct: 61  NLQDEGLDTVEANLRLGHQADERDYHVAARMLEDLGVKSVRLMTNNPKKIDELRRYGIPI 120

Query: 166 VERVPLIVGRNPNNEHYLDTKAEKMGHLLN 195
             RVP+    +P N  YL  K EKM H+L+
Sbjct: 121 AARVPIEAPSHPENVRYLRAKVEKMSHMLS 150


>UniRef50_Q4L7B1 GTP cyclohydrolase-2 n=3 Tax=Staphylococcus RepID=RIBBA_STAHJ
          Length = 393

 Score =  174 bits (442), Expect = 1e-42,   Method: Compositional matrix adjust.
 Identities = 92/188 (48%), Positives = 119/188 (63%), Gaps = 3/188 (1%)

Query: 7   AEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCD 66
           A+  +PT  G F M GFE   T  + V L  G+      V  R+HS CLTGD   S RCD
Sbjct: 209 AKVNMPTDHGAFEMYGFESSLTKEEIVVLAKGEPRVTENV--RIHSACLTGDIFHSQRCD 266

Query: 67  CGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAAD 126
           CG QLE+A+  I E G G+++Y  QEGR IGL+NK+RAY L +QG+DTV AN  LGF  D
Sbjct: 267 CGAQLESAMKYINEHG-GMIIYLPQEGRGIGLINKLRAYELIEQGHDTVTANLALGFDED 325

Query: 127 ERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTK 186
            RD+ + A +     V +V LL+NNPKK E L+E GI + +R P+IV  N +N  Y++TK
Sbjct: 326 LRDYHIAAQILNYFNVQQVNLLSNNPKKFEGLSEYGIKVADRTPIIVAENEHNHDYMNTK 385

Query: 187 AEKMGHLL 194
             KMGHL+
Sbjct: 386 KIKMGHLI 393


>UniRef50_A0JVK1 GTP cyclohydrolase-2 n=2 Tax=Micrococcaceae RepID=A0JVK1_ARTS2
          Length = 237

 Score =  174 bits (441), Expect = 1e-42,   Method: Compositional matrix adjust.
 Identities = 96/188 (51%), Positives = 121/188 (64%), Gaps = 5/188 (2%)

Query: 10  KLPTPWGDFLMVGFEELATGHDHVALVYG--DISGHTPVLARVHSECLTGDALFSLRCDC 67
           +LP+ +GDF+   + +L TG +H+A+      + G  P L R+HSECLTGD   S RCDC
Sbjct: 26  QLPSEFGDFVAQAWTDLVTGAEHLAVSSPIPPVDGKAP-LVRLHSECLTGDVFGSYRCDC 84

Query: 68  GFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAAD 126
           G QL  AL +I EEG G LLY R QEGR IGL NKI+AYALQ+ G+DTVEAN QLG   D
Sbjct: 85  GEQLAYALEKINEEG-GTLLYLRGQEGRGIGLANKIKAYALQEAGFDTVEANEQLGLPVD 143

Query: 127 ERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTK 186
            R +   A +   LG++EVRLL+NNP K   L +AG+ +VE VP  V     N  YL TK
Sbjct: 144 ARCYNAAAQILAELGLHEVRLLSNNPDKQNRLADAGVTVVEMVPTEVPSREQNIRYLQTK 203

Query: 187 AEKMGHLL 194
            ++M H L
Sbjct: 204 KDRMDHRL 211


>UniRef50_C0YM11 GTP cyclohydrolase-2 n=2 Tax=Chryseobacterium gleum ATCC 35910
           RepID=C0YM11_9FLAO
          Length = 198

 Score =  174 bits (441), Expect = 1e-42,   Method: Compositional matrix adjust.
 Identities = 88/194 (45%), Positives = 130/194 (67%), Gaps = 2/194 (1%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATG-HDHVALVYGDISGHTPVLARVHSECLTGDALF 61
           +K  AEA +PT  G F M+ F E       H+A++  +     PV  R HSEC+TG+   
Sbjct: 2   IKIQAEANVPTEHGTFRMIAFSENENDWMPHMAIIAENTDFSKPVNVRFHSECITGEVFH 61

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
           S +C+CG QL+AA+  I E G GI++Y RQEGRNIG++NK++AY+LQ++G DTV+AN QL
Sbjct: 62  SKKCECGQQLDAAMKYIHENG-GIIIYLRQEGRNIGIINKLKAYSLQEKGLDTVQANLQL 120

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181
           G  AD+R+F +  ++  LL V ++ LLTNNP+KV+ + ++ I++  RVPL +  N  ++ 
Sbjct: 121 GLPADDRNFGVAIEILNLLDVKDINLLTNNPEKVKYVVDSNIHLNSRVPLQIPANEISKG 180

Query: 182 YLDTKAEKMGHLLN 195
           YL TK +  GHLL+
Sbjct: 181 YLQTKKDFFGHLLD 194


>UniRef50_B7IF97 A 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase
           II n=1 Tax=Thermosipho africanus TCF52B
           RepID=B7IF97_THEAB
          Length = 374

 Score =  173 bits (439), Expect = 2e-42,   Method: Compositional matrix adjust.
 Identities = 96/189 (50%), Positives = 120/189 (63%), Gaps = 3/189 (1%)

Query: 7   AEAKLPTPWG-DFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRC 65
              KLPT    DF +  F+      +H+A+V        P L R+HSEC TGD   SLRC
Sbjct: 182 TSVKLPTAIDEDFDIYTFKNPYDSREHIAIVKRPFKESIPYL-RIHSECATGDIFHSLRC 240

Query: 66  DCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAA 125
           DCG QLE +L  I+++G G+L+Y RQEGR IGL NK++AY LQD+GYDTVEAN +LGF  
Sbjct: 241 DCGEQLENSLKIISKKG-GVLIYLRQEGRGIGLNNKVKAYKLQDEGYDTVEANLKLGFKD 299

Query: 126 DERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDT 185
           DERD+     + K L +NEV++LTNNPKK E L   GI I E V +    N  N+ YL T
Sbjct: 300 DERDYFAAYLILKALKINEVKILTNNPKKYEDLKRYGIKIKEIVNIYGKVNKYNKKYLFT 359

Query: 186 KAEKMGHLL 194
           KA+KM H L
Sbjct: 360 KAKKMKHNL 368


>UniRef50_UPI000050F87F bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP
           cyclohydrolase II protein n=1 Tax=Brevibacterium linens
           BL2 RepID=UPI000050F87F
          Length = 464

 Score =  173 bits (438), Expect = 4e-42,   Method: Compositional matrix adjust.
 Identities = 95/207 (45%), Positives = 121/207 (58%), Gaps = 16/207 (7%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYG-------------DISGHTPV-LA 48
           ++  AE  LPT  G F    F     GHDH+ +  G             + S H P  L 
Sbjct: 240 IEASAEVPLPTKHGSFSARAF--TIDGHDHLGVFSGIDSAAVAHEPAGQEPSLHGPAPLV 297

Query: 49  RVHSECLTGDALFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQ 108
           RVHSECLTGD   S RCDCG QL+ AL QI++EG  ++     EGR IGL NK+RAYALQ
Sbjct: 298 RVHSECLTGDVFGSHRCDCGEQLDLALQQISDEGGTVIYMTGHEGRGIGLSNKLRAYALQ 357

Query: 109 DQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVER 168
           D+G DTV+AN +LGF  D+RD+   A++ + +G+  +RLLTNNP K   L   GI I   
Sbjct: 358 DRGLDTVDANRELGFHDDDRDYRAAAEILRSIGLTHIRLLTNNPDKTRALESLGITIEAV 417

Query: 169 VPLIVGRNPNNEHYLDTKAEKMGHLLN 195
           VPL +   P N +YL+TK E+M H L 
Sbjct: 418 VPLEIPARPENSNYLNTKRERMHHTLT 444


>UniRef50_A7I3X0 GTP cyclohydrolase-2 n=6 Tax=cellular organisms RepID=RIBA_CAMHC
          Length = 193

 Score =  172 bits (436), Expect = 6e-42,   Method: Compositional matrix adjust.
 Identities = 92/187 (49%), Positives = 119/187 (63%), Gaps = 7/187 (3%)

Query: 9   AKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCG 68
           AKLP+ +G F +  F+E    H    LV        PV  R+HSECLTGDA+ SL+CDC 
Sbjct: 9   AKLPSRFGMFKVQAFKEDEKEH----LVIIKEPYKEPVNIRIHSECLTGDAIGSLKCDCR 64

Query: 69  FQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADER 128
            QLE +L  I + G G+++Y RQEGRNIGL NKI AY LQD+G DT+EANHQLGF  DER
Sbjct: 65  DQLEESLKFIEKNG-GMVIYLRQEGRNIGLFNKINAYNLQDKGLDTIEANHQLGFKTDER 123

Query: 129 DFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAE 188
            + +   + K   +  + LLTNNPKK  ++    + +  RVP+I+  N  NE YL TK  
Sbjct: 124 TYEIVDFILKYYKIKSINLLTNNPKK--LMGLHNVKVAARVPIIIKPNKFNEKYLQTKKN 181

Query: 189 KMGHLLN 195
           +MGHLL+
Sbjct: 182 EMGHLLD 188


>UniRef50_C6X006 GTP cyclohydrolase-2 n=1 Tax=Flavobacteriaceae bacterium 3519-10
           RepID=C6X006_FLAB3
          Length = 204

 Score =  172 bits (435), Expect = 7e-42,   Method: Compositional matrix adjust.
 Identities = 82/194 (42%), Positives = 128/194 (65%), Gaps = 2/194 (1%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATG-HDHVALVYGDISGHTPVLARVHSECLTGDALF 61
           LK  AEA +PT +G F ++   E       H+A+V  +     PV  R HSEC+TG+   
Sbjct: 2   LKIQAEANVPTEFGSFRIIALSETDNNWMPHLAIVAENTDFCQPVNVRFHSECITGEVFH 61

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
           S +C+CG QL+AA+  + E G GI++Y RQEGRNIG++NK++AY+LQ++G+DTVEAN +L
Sbjct: 62  SKKCECGQQLDAAMKYMHENG-GIIIYLRQEGRNIGIINKLKAYSLQEKGFDTVEANLEL 120

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181
           G  AD+R+F +  ++  +L V +V LLTNNP+K++++  + I++  R+PL +    ++  
Sbjct: 121 GLPADDRNFAVAVEILNILEVKDVNLLTNNPEKIKVVENSNIHLNSRIPLQISSTTDSAS 180

Query: 182 YLDTKAEKMGHLLN 195
           YL  K +  GH L+
Sbjct: 181 YLKVKKDFFGHFLD 194


>UniRef50_Q17XC9 GTP cyclohydrolase-2 n=13 Tax=Helicobacter RepID=RIBA_HELAH
          Length = 192

 Score =  171 bits (434), Expect = 8e-42,   Method: Compositional matrix adjust.
 Identities = 92/189 (48%), Positives = 126/189 (66%), Gaps = 7/189 (3%)

Query: 8   EAKLPTPWGDFLMVGFEELAT--GHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRC 65
           +AKLPT +G+F +  F E  +    DH+ +   D     P L R+HSECLTGDAL S +C
Sbjct: 9   QAKLPTQFGEFYIQCFREKNSNGSKDHLVIFTLDFP-ENP-LVRLHSECLTGDALGSQKC 66

Query: 66  DCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAA 125
           DCG  L+ AL +I++EG G+++Y RQEGR IGL NK+ AYALQD+GYDT++AN  +GF  
Sbjct: 67  DCGVALQMALERISKEG-GLVIYLRQEGRGIGLFNKVNAYALQDKGYDTIQANEMIGFKD 125

Query: 126 DERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDT 185
           DERD+ +  ++ +   + ++RLLTNNPKK+  L +     V R  LIV  N +N+ YL+ 
Sbjct: 126 DERDYGIAGEILEYYRIKKMRLLTNNPKKIAALEKYA--EVTRESLIVCANEHNQGYLEV 183

Query: 186 KAEKMGHLL 194
           K  KMGHLL
Sbjct: 184 KKLKMGHLL 192


>UniRef50_C4K9I6 GTP cyclohydrolase-2 n=1 Tax=Thauera sp. MZ1T RepID=C4K9I6_THASP
          Length = 385

 Score =  168 bits (425), Expect = 1e-40,   Method: Compositional matrix adjust.
 Identities = 91/196 (46%), Positives = 122/196 (62%), Gaps = 2/196 (1%)

Query: 2   QLKRVAEAKLPTPWGD-FLMVGFEELATGHDHVALVYGDISGHTP-VLARVHSECLTGDA 59
           +L R++EA++P    +    V F E    H+HVA+V G+ +     V  R+HS CLTGD 
Sbjct: 164 RLARISEARVPLAEAENSRFVLFREADGVHEHVAIVIGERANWPEDVPVRLHSSCLTGDL 223

Query: 60  LFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANH 119
             SLRCDCG QL   +  I   G G+LLY  QEGR IGL NK+RAY LQD+G DT++A+ 
Sbjct: 224 FGSLRCDCGEQLRRGVAAIDALGGGVLLYLSQEGRGIGLANKLRAYGLQDEGLDTIDADQ 283

Query: 120 QLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNN 179
            +GF+ DERDF +  +M   LG++ + LLTNNP KV  L +AGI++V R  +       N
Sbjct: 284 VIGFSKDERDFRIAHEMLDELGIDRILLLTNNPSKVAALQKAGIHVVGRRAIYGEVTVQN 343

Query: 180 EHYLDTKAEKMGHLLN 195
           + YL TKA + GH LN
Sbjct: 344 QRYLRTKASRHGHWLN 359


>UniRef50_B8H6T8 GTP cyclohydrolase-2 n=1 Tax=Arthrobacter chlorophenolicus A6
           RepID=B8H6T8_ARTCA
          Length = 243

 Score =  167 bits (423), Expect = 2e-40,   Method: Compositional matrix adjust.
 Identities = 95/188 (50%), Positives = 119/188 (63%), Gaps = 5/188 (2%)

Query: 10  KLPTPWGDFLMVGFEELATGHDHVALVYGD--ISGHTPVLARVHSECLTGDALFSLRCDC 67
           +LPT +GDF+   + +L TG +H+A+   +    G  P L R+HSECLTGD   S RCDC
Sbjct: 35  QLPTAFGDFVAQAWTDLVTGVEHLAVSSPNPPSDGKAP-LVRLHSECLTGDVFGSYRCDC 93

Query: 68  GFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAAD 126
           G QL  AL  I E G G LLY R QEGR IGL NKI+AYALQ+ G+DTVEAN QLG   D
Sbjct: 94  GEQLAYALELIHEHG-GTLLYLRGQEGRGIGLANKIKAYALQEAGFDTVEANEQLGLPVD 152

Query: 127 ERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTK 186
            R +   A +   +G++EVRLL+NNP K   L +AG+ +VE VP  V     N  YL TK
Sbjct: 153 ARCYKAAAQVLAEMGLHEVRLLSNNPDKQNRLAKAGVKVVEMVPTEVPSREQNIRYLRTK 212

Query: 187 AEKMGHLL 194
            ++M H L
Sbjct: 213 KDRMEHRL 220


>UniRef50_Q1QYD0 GTP cyclohydrolase-2 n=1 Tax=Chromohalobacter salexigens DSM 3043
           RepID=Q1QYD0_CHRSD
          Length = 378

 Score =  167 bits (423), Expect = 2e-40,   Method: Compositional matrix adjust.
 Identities = 91/196 (46%), Positives = 118/196 (60%), Gaps = 2/196 (1%)

Query: 2   QLKRVAEAKLPTPWGDFL-MVGFEELATGHDHVALVYGDISGHT-PVLARVHSECLTGDA 59
            LKR++EA++P    D    V F E     +H+A++ GD +     V  R+HS CLTGD 
Sbjct: 164 SLKRISEAEIPLAEADRTRFVLFRESDGLREHLAVLVGDPAQWADAVPTRLHSACLTGDL 223

Query: 60  LFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANH 119
             SLRCDCG QL  ++  IAE G GILLY  QEGR IGL NK+RAY LQD G DTV+A+ 
Sbjct: 224 FGSLRCDCGEQLRGSVAAIAERGGGILLYLAQEGRGIGLANKLRAYHLQDDGLDTVDADQ 283

Query: 120 QLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNN 179
            LGF  DER + +   M + L V  + LLTNNP K++ ++  G+ +V R       N +N
Sbjct: 284 VLGFGDDERRYHVALQMLEALAVTRIELLTNNPGKIDAMSRGGVEVVGRQACYGKLNEHN 343

Query: 180 EHYLDTKAEKMGHLLN 195
             YL  KAE+ GH LN
Sbjct: 344 RRYLSAKAERAGHWLN 359


>UniRef50_A6VWW9 GTP cyclohydrolase-2 n=47 Tax=Bacteria RepID=RIBA_MARMS
          Length = 202

 Score =  166 bits (421), Expect = 3e-40,   Method: Compositional matrix adjust.
 Identities = 90/189 (47%), Positives = 119/189 (62%), Gaps = 6/189 (3%)

Query: 11  LPTPWGDFL--MVGFEELATGHDHVALVYGDISG---HTPVLARVHSECLTGDALFSLRC 65
           +P   GD +   + F    +G +H+ + +        ++  L R+HSECLTGD   S RC
Sbjct: 12  IPVRAGDVMAEFISFNGDDSGKEHIGIFFEGTKAKADNSIPLVRLHSECLTGDVFGSGRC 71

Query: 66  DCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAA 125
           DCG QL+ A+ +I EEG G +LY RQEGR IGL  K+ AYALQDQGYDT +AN  L    
Sbjct: 72  DCGEQLDEAIDRINEEG-GYILYLRQEGRGIGLYAKLEAYALQDQGYDTYQANEMLHLPD 130

Query: 126 DERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDT 185
           D RDF + A+M + LGV++VRLLTNNP K + L E GI++ E VP  V  N +N  YL+T
Sbjct: 131 DGRDFGIAAEMLQALGVSKVRLLTNNPDKAQQLIEHGIDVAELVPTKVHVNQHNRSYLET 190

Query: 186 KAEKMGHLL 194
           KA++  H L
Sbjct: 191 KAKRKQHTL 199


>UniRef50_A8IZV5 Bifunctional GTP cyclohydrolase II n=1 Tax=Chlamydomonas
           reinhardtii RepID=A8IZV5_CHLRE
          Length = 370

 Score =  165 bits (418), Expect = 7e-40,   Method: Compositional matrix adjust.
 Identities = 85/193 (44%), Positives = 118/193 (61%), Gaps = 4/193 (2%)

Query: 6   VAEAKLPTPWGDFLMVGFEEL----ATGHDHVALVYGDISGHTPVLARVHSECLTGDALF 61
           +AE  LPT  G F + G++      AT  +  A+V G + G   V  RVH  C T + L 
Sbjct: 86  IAETLLPTRHGKFRLRGYKHSTDGGATFTEPTAIVSGKVEGQEDVAVRVHDACFTSEVLG 145

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
           SL+CDC  QLE AL  I     GI++Y +QEGR IGL NKI AY+LQ+QG DTV+AN  L
Sbjct: 146 SLKCDCAEQLELALRMIQGAPPGIVIYLQQEGRGIGLANKIAAYSLQEQGLDTVDANRAL 205

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181
           G   D R++T   +M + +GV  +RL+TNNP+K+  LT+ GI +  R+P +V     N+ 
Sbjct: 206 GLPDDCREYTSVRNMLQDMGVKSIRLITNNPRKINTLTKLGIQVNGRIPCLVAAGAYNQG 265

Query: 182 YLDTKAEKMGHLL 194
           YL+ K ++M H+L
Sbjct: 266 YLEAKRDRMAHML 278


>UniRef50_B9ZQZ7 GTP cyclohydrolase-2 n=1 Tax=Thioalkalivibrio sp. K90mix
           RepID=B9ZQZ7_9GAMM
          Length = 381

 Score =  164 bits (416), Expect = 1e-39,   Method: Compositional matrix adjust.
 Identities = 91/200 (45%), Positives = 122/200 (61%), Gaps = 6/200 (3%)

Query: 1   MQLKRVAEAKLPTPWGDFLMVGFEELATGH---DHVALVYGDISGHT-PVLARVHSECLT 56
           ++L  V+EA  P P  D  +  F     G+   +HVA+V G+ +     V  R+HS CLT
Sbjct: 175 LELAYVSEA--PVPLADAPVTRFMLFREGNGILEHVAVVIGEPNEWPDAVPVRLHSACLT 232

Query: 57  GDALFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVE 116
           GD   SLRCDCG QL   +  I E G G+LLY  QEGR IGL NK+RAY +Q  G DT++
Sbjct: 233 GDLFGSLRCDCGDQLRLGVKTINESGGGVLLYLAQEGRGIGLANKLRAYTMQTAGLDTID 292

Query: 117 ANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRN 176
           ++ QLGF AD R +    +M + LG++ VR+LTNNP K+E L   GI +V R P+    N
Sbjct: 293 SDCQLGFEADGRRYDAAVEMLEFLGIDTVRVLTNNPAKIEALRAGGIRVVAREPVHGTLN 352

Query: 177 PNNEHYLDTKAEKMGHLLNK 196
           P+N  YL TKA++ GH L +
Sbjct: 353 PHNLRYLSTKADRGGHWLQE 372


>UniRef50_D2LG53 GTP cyclohydrolase II n=1 Tax=Rhodomicrobium vannielii ATCC 17100
           RepID=D2LG53_RHOVA
          Length = 383

 Score =  164 bits (416), Expect = 1e-39,   Method: Compositional matrix adjust.
 Identities = 79/166 (47%), Positives = 105/166 (63%)

Query: 30  HDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQIAEEGRGILLYH 89
            D +A++ G+ +   PV  R+HS CLTGD   SL+CDCG QL   +  +AEEG G +LY 
Sbjct: 198 RDQIAILVGNPTPGKPVSVRIHSACLTGDLFGSLKCDCGEQLRGTVRAMAEEGGGAVLYL 257

Query: 90  RQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNEVRLLT 149
            QEGR  G+ NKIRAY LQDQG+DT +A+  LGF  D+R F   ADM +LLG   VRL+T
Sbjct: 258 DQEGRGNGIANKIRAYRLQDQGFDTYDADELLGFGQDQRRFDFAADMLRLLGFTSVRLMT 317

Query: 150 NNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAEKMGHLLN 195
           NNP K++ L + G+N++    ++      N  YL  K +K GHLL 
Sbjct: 318 NNPLKIKALRDGGLNVLSTHRVLTRPTAQNVKYLAAKRDKAGHLLG 363


>UniRef50_O29766 GTP cyclohydrolase-2 n=1 Tax=Archaeoglobus fulgidus
           RepID=RIBA_ARCFU
          Length = 378

 Score =  163 bits (413), Expect = 3e-39,   Method: Compositional matrix adjust.
 Identities = 96/194 (49%), Positives = 122/194 (62%), Gaps = 6/194 (3%)

Query: 3   LKRVAEAKLPTP-WGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALF 61
           ++RV EA LPT  +G F  VG++      + VALV G +     VL R+HSECLTGD   
Sbjct: 185 VERVIEATLPTKFYGTFRAVGYK--TPLGEIVALVKGRVD-EGDVLVRIHSECLTGDVFH 241

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVEANHQ 120
           SLRCDCG QLE AL  I  EG+G+ +Y R  EGR IGL+NK+ AY LQ++G DTV+AN +
Sbjct: 242 SLRCDCGDQLENALKMIDREGKGVAIYMRGHEGRGIGLINKLMAYKLQEEGKDTVDANIE 301

Query: 121 LGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNE 180
           LGF  D R + + A +   L V  +RLLTNNP K+E L + G  IV R P+ V     N 
Sbjct: 302 LGFPPDMRSYGIAAQILMDLKVKSIRLLTNNPLKIEELKKYGFKIV-REPIEVEPCEVNL 360

Query: 181 HYLDTKAEKMGHLL 194
            YL  K +KMGHL+
Sbjct: 361 PYLKAKKDKMGHLI 374


>UniRef50_Q03XZ0 GTP cyclohydrolase II n=1 Tax=Leuconostoc mesenteroides subsp.
           mesenteroides ATCC 8293 RepID=Q03XZ0_LEUMM
          Length = 397

 Score =  162 bits (410), Expect = 6e-39,   Method: Compositional matrix adjust.
 Identities = 85/184 (46%), Positives = 113/184 (61%), Gaps = 2/184 (1%)

Query: 11  LPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQ 70
           LPT +GDF +  F  +        L+    S     L R+HSECLTG+   S RC+CG Q
Sbjct: 216 LPTQYGDFHLTEFS-VNDEEKSDLLIQSSRSFDQIPLVRLHSECLTGEIFGSQRCECGPQ 274

Query: 71  LEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDF 130
           L  AL  I ++G G L+Y RQEGR IGL  K+++Y LQ+  +DT +AN  LG   DERD+
Sbjct: 275 LREALKTINKQG-GALVYLRQEGRGIGLHEKLKSYVLQENKFDTYDANVHLGHLPDERDY 333

Query: 131 TLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAEKM 190
              A + K+ G+ ++RLLTNNP KV+ L + GI ++E+VPLI G N  NE Y+ TK EK 
Sbjct: 334 KKAAKILKISGLTKIRLLTNNPDKVQSLIDEGIEVIEQVPLITGINDKNEQYMQTKKEKF 393

Query: 191 GHLL 194
            H L
Sbjct: 394 NHKL 397


>UniRef50_A4XHM6 GTP cyclohydrolase II n=2 Tax=Clostridia RepID=A4XHM6_CALS8
          Length = 402

 Score =  162 bits (409), Expect = 8e-39,   Method: Compositional matrix adjust.
 Identities = 80/190 (42%), Positives = 114/190 (60%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           +++ AEA LPT +G F +  F+   +  +H  L+    +   PV  R+HS C TGD   S
Sbjct: 200 VQKEAEANLPTQYGKFKIFVFKNYFSQKEHAVLINQTFNPSQPVNVRIHSSCKTGDVFHS 259

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
           LRCDC  QLE  L  +AE    +L+Y  QEGR IG  NKI+AYALQ+QG+DT EAN+ LG
Sbjct: 260 LRCDCHQQLEFFLHFMAENKNCMLIYLDQEGRGIGFANKIKAYALQEQGFDTYEANNLLG 319

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHY 182
           F  D RD+     + +  G+ ++ L T+NP+KV  L + GI I++R+ + +  NP N  Y
Sbjct: 320 FDDDLRDYFDALHILRFFGIKKINLATSNPEKVSFLQDLGIEILKRISIPIVINPYNRKY 379

Query: 183 LDTKAEKMGH 192
           + +K  K  H
Sbjct: 380 IHSKILKKKH 389


>UniRef50_A4RYG5 Predicted protein n=1 Tax=Ostreococcus lucimarinus CCE9901
           RepID=A4RYG5_OSTLU
          Length = 250

 Score =  161 bits (408), Expect = 9e-39,   Method: Compositional matrix adjust.
 Identities = 86/195 (44%), Positives = 118/195 (60%), Gaps = 4/195 (2%)

Query: 6   VAEAKLPTPWGDFLMVGFEEL--ATGH--DHVALVYGDISGHTPVLARVHSECLTGDALF 61
           VAE KLPT  G + +  +      TG   + V ++YGD+ G   V  RVH  C T + L 
Sbjct: 13  VAETKLPTDKGFYRVRAYRHANPTTGDVTEPVCVIYGDVEGRENVPVRVHDACFTSEVLG 72

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
           S++CDC  QLE A+  I E G GI+ Y +QEGR IGL NKI AYA+Q++G DTV+AN +L
Sbjct: 73  SMKCDCKQQLEMAMDYIKENGPGIVCYLQQEGRGIGLANKIAAYAVQEEGVDTVDANRRL 132

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181
           G   D R++T   +M + L V  V+L+TNNP+K+  L   GI I  R+  +V  N  NE 
Sbjct: 133 GLPDDTREYTAVENMLRELDVRSVQLMTNNPRKIRELECGGIKITGRIACVVKANLFNEG 192

Query: 182 YLDTKAEKMGHLLNK 196
           YL  K  +M H+L++
Sbjct: 193 YLAAKERRMSHVLDQ 207


>UniRef50_A1SSA8 GTP cyclohydrolase-2 n=10 Tax=Gammaproteobacteria RepID=RIBA_PSYIN
          Length = 200

 Score =  160 bits (404), Expect = 3e-38,   Method: Compositional matrix adjust.
 Identities = 86/196 (43%), Positives = 121/196 (61%), Gaps = 9/196 (4%)

Query: 1   MQLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYG--DISGHTPVLARVHSECLTGD 58
           + LK  A +++P       +  F  L +  +H+A+++G  D    +P++ R+HSECLTGD
Sbjct: 8   ISLKIGANSRIPAQ-----IASFNGLTSDKEHIAIIFGKADECSSSPIV-RIHSECLTGD 61

Query: 59  ALFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEAN 118
              S RCDCG QL+ A+  + +EG GI++Y RQEGR IGL NKI AY LQ +G DT +AN
Sbjct: 62  VFHSSRCDCGEQLDEAIELMEKEG-GIIIYLRQEGRGIGLYNKIDAYKLQSEGMDTYQAN 120

Query: 119 HQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPN 178
           +QLGF  D RDFT    M   L + +++LLTNNP KV+ L E GI + + +        +
Sbjct: 121 NQLGFEDDLRDFTEAGQMLAALNIRKLQLLTNNPLKVKALREYGITVDKVISTSTFIKDD 180

Query: 179 NEHYLDTKAEKMGHLL 194
           NE YL TKA+  GH +
Sbjct: 181 NESYLRTKAKNAGHAI 196


>UniRef50_P51618 GTP cyclohydrolase-2 n=63 Tax=Gammaproteobacteria RepID=RIBA_PHOPO
          Length = 200

 Score =  159 bits (403), Expect = 4e-38,   Method: Compositional matrix adjust.
 Identities = 87/177 (49%), Positives = 110/177 (62%), Gaps = 2/177 (1%)

Query: 20  MVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQIA 79
           ++ F  L +G +H+AL++ D       L R+HSECLTGD   S RCDCG QL+  +  +A
Sbjct: 22  LLSFNGLESGKEHIALIFKDAYKAFVPLVRMHSECLTGDGFHSTRCDCGEQLDETIEIMA 81

Query: 80  EEGRGILLYHRQEGR-NIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFK 138
           E G GI+LY RQEGR  +GL NKI AY LQ QG DT EAN+ LGF  D R+F+  A M  
Sbjct: 82  ELG-GIILYLRQEGRWGLGLYNKIDAYKLQSQGMDTYEANNHLGFDDDLREFSEAAQMLT 140

Query: 139 LLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAEKMGHLLN 195
            LG+ ++RL+TNNPKK++ L + GINIVE V         NE YL  KA    H  N
Sbjct: 141 ALGIKDIRLVTNNPKKIKDLQQNGINIVEVVGTKAHLKEGNEGYLKAKASHGRHCFN 197


>UniRef50_C1E155 Predicted protein n=2 Tax=Micromonas RepID=C1E155_9CHLO
          Length = 357

 Score =  159 bits (402), Expect = 5e-38,   Method: Compositional matrix adjust.
 Identities = 86/194 (44%), Positives = 119/194 (61%), Gaps = 5/194 (2%)

Query: 6   VAEAKLPTPWGDFLMVGFEELATG---HDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           +AE KLPT  G + + G+     G    + VA+ +GDI G   V  RVH  C T + L S
Sbjct: 128 IAETKLPTGSGFYRLRGYRHSVDGGVPSEPVAICFGDIEGREKVPVRVHDACFTSEVLGS 187

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQD-QGYDTVEANHQL 121
           L+CDC  QL+ A+  I +E  G+++Y  QEGR IGL NKI AYALQD QG DTV+AN  L
Sbjct: 188 LKCDCKQQLQLAMEYI-QENDGMVIYLHQEGRGIGLANKIAAYALQDTQGLDTVDANRAL 246

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181
           G   D R++T  A++ + +G+  ++L+TNNP+KV  L   G+ I  R+P IV  N  N+ 
Sbjct: 247 GLPDDVREYTAVANILEDMGIRSIQLMTNNPRKVATLERLGVKIEGRIPCIVKANLFNQG 306

Query: 182 YLDTKAEKMGHLLN 195
           YL+ K  +M H L+
Sbjct: 307 YLEAKEGRMKHFLD 320


>UniRef50_D2NTM1 GTP cyclohydrolase II n=2 Tax=Rothia mucilaginosa
           RepID=D2NTM1_9MICC
          Length = 278

 Score =  156 bits (395), Expect = 4e-37,   Method: Compositional matrix adjust.
 Identities = 92/203 (45%), Positives = 118/203 (58%), Gaps = 12/203 (5%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLA--------RVHSEC 54
           ++   E  +PTP G F +  +   A G +H++    D  G TPV A        R+HSEC
Sbjct: 78  VESTEEVAVPTPQGLFGLRAWR-FADGAEHISARALDRDG-TPVPAEDGGALAVRIHSEC 135

Query: 55  LTGDALFSLRCDCGFQLEAALTQIAEEGRGILLYHRQ-EGRNIGLLNKIRAYALQDQGYD 113
            TGD   S RCDCG QLE  L  I   G G L+Y R  EGR IGL+NK+RAYALQD G D
Sbjct: 136 ATGDIFGSFRCDCGPQLENGLRIIGRTG-GYLIYVRNHEGRGIGLVNKLRAYALQDAGLD 194

Query: 114 TVEANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIV 173
           T++AN  LG   D RD++  A + + LGVNE+RL+TNNP K E L   G+ + E +P  +
Sbjct: 195 TLDANLALGLDGDMRDYSQAALILQELGVNELRLVTNNPAKQEALESLGLQVTELIPDEI 254

Query: 174 GRNPNNEHYLDTKAEKMGHLLNK 196
                N HYL TK E+M H+L  
Sbjct: 255 PARVENAHYLQTKRERMRHVLKS 277


>UniRef50_A6W477 GTP cyclohydrolase-2 n=8 Tax=Bacteria RepID=A6W477_KINRD
          Length = 206

 Score =  155 bits (392), Expect = 7e-37,   Method: Compositional matrix adjust.
 Identities = 86/173 (49%), Positives = 101/173 (58%), Gaps = 1/173 (0%)

Query: 23  FEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQIAEEG 82
           F  L  G +H+AL  GD    +  L R HSECLTGD   S RCDCG QL  A+ +IA  G
Sbjct: 32  FTGLVDGKEHLALGLGDWRQQSTPLVRPHSECLTGDVFGSERCDCGPQLREAVERIATTG 91

Query: 83  RGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGV 142
            G LLY RQEGR IGL  K+ AYALQD G DT EAN  LG   DERD+ + A M   LGV
Sbjct: 92  -GFLLYLRQEGRGIGLYAKLDAYALQDSGLDTYEANLALGRGEDERDYAVAAQMLDALGV 150

Query: 143 NEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAEKMGHLLN 195
             + LL+NNP K E L   GI +  RVP  V  + +N  YL  K +   H L+
Sbjct: 151 ERIALLSNNPDKAEQLVRHGIAVERRVPTGVHLSASNARYLRAKRDHTSHTLD 203


>UniRef50_D0NCB5 Riboflavin biosynthesis protein ribBA, putative n=2
           Tax=Phytophthora infestans T30-4 RepID=D0NCB5_PHYIN
          Length = 367

 Score =  155 bits (391), Expect = 9e-37,   Method: Compositional matrix adjust.
 Identities = 78/191 (40%), Positives = 117/191 (61%), Gaps = 3/191 (1%)

Query: 6   VAEAKLPTPWGDFLMVGFEELAT--GHDHVALVYGDISGHTPVLARVHSECLTGDALFSL 63
           VAE  LPT  G F +  +  + +    + +A++ GD+ G   V  RVH +C T +   SL
Sbjct: 134 VAETALPTDGGMFRVRAYRSVGSLRESEPIAMITGDVRGKRNVPVRVHDQCFTSEVFGSL 193

Query: 64  RCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGF 123
           +CDC  QL+ A     + G G+++Y  QEGR IGL NKI AY++Q++G DTV+AN  LGF
Sbjct: 194 KCDCRDQLDYAKAYTKQHG-GVVIYMPQEGRGIGLANKIMAYSMQERGLDTVDANRVLGF 252

Query: 124 AADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYL 183
             D R +     + K LGV  +RLLTNNP+K+ +L++ GI +  R+P+++     ++ YL
Sbjct: 253 KDDYRSYEPVPAILKDLGVQSIRLLTNNPRKIRLLSQLGITVEGRLPVVIKGGEFSQGYL 312

Query: 184 DTKAEKMGHLL 194
             KA++M HLL
Sbjct: 313 TAKAKRMSHLL 323


>UniRef50_Q83FM7 GTP cyclohydrolase-2 n=2 Tax=Tropheryma whipplei RepID=Q83FM7_TROWT
          Length = 211

 Score =  154 bits (390), Expect = 1e-36,   Method: Compositional matrix adjust.
 Identities = 83/187 (44%), Positives = 116/187 (62%), Gaps = 4/187 (2%)

Query: 7   AEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCD 66
            E  LPT +G   + G+ ++   ++H+AL+   I     VL R+HSEC+TG+   SL+CD
Sbjct: 24  VETNLPTKFGTLRVRGYRDIKN-NEHIALITKQIKSED-VLLRIHSECITGEVFMSLKCD 81

Query: 67  CGFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAA 125
           C  QL  AL +I+ EG G+++Y R  EGR IG+LNK+RAY LQ+QG DT ++N +LG   
Sbjct: 82  CHGQLHKALERISAEG-GLVIYMRGHEGRGIGILNKLRAYRLQEQGLDTFDSNVKLGLPV 140

Query: 126 DERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDT 185
           D RD+   A++   LGV  VRLL+NNP K   L ++GI +   +P  VG    N  YL  
Sbjct: 141 DARDYGPAAEILHDLGVRSVRLLSNNPDKQLQLEQSGIRVTGVLPWQVGLGKCNHEYLKV 200

Query: 186 KAEKMGH 192
           K +KMGH
Sbjct: 201 KRDKMGH 207


>UniRef50_Q87D69 GTP cyclohydrolase-2 n=22 Tax=Proteobacteria RepID=RIBA_XYLFT
          Length = 398

 Score =  154 bits (388), Expect = 2e-36,   Method: Compositional matrix adjust.
 Identities = 86/191 (45%), Positives = 110/191 (57%), Gaps = 7/191 (3%)

Query: 10  KLPTPWGDFLMVGFEELATG---HDHVALVYG--DISGHTPVLARVHSECLTGDALFSLR 64
           + P P  D  M  F     G    D VA++ G  D+S   PV  RVHS CLTGD   SL+
Sbjct: 178 RTPVPLRDLGMSEFIVFRGGIAQRDQVAILIGRPDLSSAVPV--RVHSSCLTGDLFGSLK 235

Query: 65  CDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFA 124
           CDCG QL  +L  +   G G+LLY  QEGR  G+  KIRAY  Q  G DT++A+ QLGF 
Sbjct: 236 CDCGDQLRHSLATLKALGGGVLLYLDQEGRGNGIAAKIRAYGYQHVGLDTIDADAQLGFG 295

Query: 125 ADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLD 184
            DER +T    M + LG+  ++LL+NNP K E L  AGI + +R+ +I      NEHYL 
Sbjct: 296 PDERRYTGAVMMLRALGITRIQLLSNNPAKAERLRAAGIIVKQRISVIGQITKQNEHYLR 355

Query: 185 TKAEKMGHLLN 195
           TK  + GH L+
Sbjct: 356 TKVSRAGHDLD 366


>UniRef50_C6QGG9 GTP cyclohydrolase-2 n=1 Tax=Hyphomicrobium denitrificans ATCC
           51888 RepID=C6QGG9_9RHIZ
          Length = 213

 Score =  153 bits (387), Expect = 2e-36,   Method: Compositional matrix adjust.
 Identities = 78/155 (50%), Positives = 104/155 (67%), Gaps = 2/155 (1%)

Query: 41  SGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQIAEEGRGILLYHR-QEGRNIGLL 99
           S   PV+ R+HS C+TGD   SLRCDC  QL+AAL  I E   G+++Y    EGR IGL 
Sbjct: 60  SAAIPVV-RIHSGCVTGDIFHSLRCDCYQQLQAALKAITEVPLGVIVYAPYHEGRGIGLF 118

Query: 100 NKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILT 159
            KI+AYALQDQG DTVEAN ++G   D RD++L A + + LG+ E++LL+NNP K + L 
Sbjct: 119 KKIQAYALQDQGLDTVEANIEVGAPIDSRDYSLAARVLQDLGMPEIKLLSNNPAKEQALK 178

Query: 160 EAGINIVERVPLIVGRNPNNEHYLDTKAEKMGHLL 194
             GI + ER+PL++  N  N+ YL+TK  +M H L
Sbjct: 179 AHGIRVAERLPLVIKPNKFNKRYLETKRARMAHKL 213


>UniRef50_B3CNI0 GTP cyclohydrolase-2 n=13 Tax=Wolbachia RepID=B3CNI0_WOLPP
          Length = 361

 Score =  151 bits (382), Expect = 1e-35,   Method: Compositional matrix adjust.
 Identities = 76/174 (43%), Positives = 109/174 (62%), Gaps = 1/174 (0%)

Query: 20  MVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQIA 79
           ++ +   + G +H A++ G+       L R+HS C TGD L SL CDC  QL  A+  + 
Sbjct: 183 IISYRTKSGGREHYAIIIGNPDKDNEPLVRIHSACYTGDLLDSLSCDCRSQLHQAIQIMT 242

Query: 80  EEGRGILLYHRQEGRNIGLLNKIRAYALQDQ-GYDTVEANHQLGFAADERDFTLCADMFK 138
           + G GI+LY  Q+GR IGL NK+RAY++Q +   DTV+AN  LGF  DER F + A + K
Sbjct: 243 DFGNGIILYLMQDGRGIGLTNKLRAYSMQRKYNLDTVDANRVLGFEDDERSFAVAAKILK 302

Query: 139 LLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAEKMGH 192
            L +N+++LLTNN +K+  L   GI + + VPLI+ RN  N  Y++TK  K+GH
Sbjct: 303 KLNINKIQLLTNNGRKLSELKNNGIEVTKCVPLIMERNEYNHSYMETKFGKLGH 356


>UniRef50_UPI000051036D riboflavin-specific deaminase/GTP cyclohydrolase II n=1
           Tax=Brevibacterium linens BL2 RepID=UPI000051036D
          Length = 473

 Score =  151 bits (381), Expect = 1e-35,   Method: Compositional matrix adjust.
 Identities = 89/186 (47%), Positives = 107/186 (57%), Gaps = 3/186 (1%)

Query: 9   AKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCG 68
           +KLPT  G F +  F    T H    +  GD +     L RVHSECLTGDAL S RCDCG
Sbjct: 19  SKLPTVHGLFTLRTFAHDGTAH--AVMSIGDPALVDAPLVRVHSECLTGDALGSHRCDCG 76

Query: 69  FQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADE 127
            QL A+L  IA+ G GIL+Y R  EGR IGL NK+RAYALQD G DTV AN  L    D 
Sbjct: 77  DQLSASLAAIAQAGDGILIYLRGHEGRGIGLENKLRAYALQDTGLDTVAANRALDLPDDA 136

Query: 128 RDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKA 187
           RD+T  A +   L   ++ LL++NP KV  L   GI + ER  L V   P +  YL+ K 
Sbjct: 137 RDYTGAAAILHDLDCPQITLLSSNPSKVTALEGMGITVAERRDLNVPDRPESAGYLEAKR 196

Query: 188 EKMGHL 193
             M H+
Sbjct: 197 RLMDHI 202


>UniRef50_C5AMM6 GTP cyclohydrolase-2 n=2 Tax=Burkholderia glumae RepID=C5AMM6_BURGB
          Length = 252

 Score =  149 bits (376), Expect = 6e-35,   Method: Compositional matrix adjust.
 Identities = 89/176 (50%), Positives = 103/176 (58%), Gaps = 4/176 (2%)

Query: 20  MVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQIA 79
           MV F  L    +H+ALV+G I G  P L R+HSECLTGD   S RCDCG QL+ ++    
Sbjct: 73  MVTFNGLCDSAEHIALVFGKI-GEAP-LVRLHSECLTGDVFGSARCDCGEQLDESIALFG 130

Query: 80  EEGRGILLYHRQEGRNIGLLNKIRAYALQ-DQGYDTVEANHQLGFAADERDFTLCADMFK 138
           E G GILLY RQEGR IGL NK+ AY LQ  QG DT  AN  L F  D RDF + A M K
Sbjct: 131 ERG-GILLYLRQEGRGIGLYNKLDAYRLQISQGLDTFAANRALNFPDDLRDFRVAAQMLK 189

Query: 139 LLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAEKMGHLL 194
            LGV EV L+TNNP K   LT  GI + +     V  N  N  YL  KA +  H +
Sbjct: 190 ALGVGEVSLVTNNPDKTAQLTRHGIKVRQVKSTGVFANSVNFGYLHAKATQHRHAI 245


>UniRef50_Q4V1U4 GTP cyclohydrolase-2 n=26 Tax=Bacillus cereus group
           RepID=Q4V1U4_BACCZ
          Length = 245

 Score =  146 bits (369), Expect = 3e-34,   Method: Compositional matrix adjust.
 Identities = 79/169 (46%), Positives = 97/169 (57%), Gaps = 1/169 (0%)

Query: 26  LATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQIAEEGRGI 85
           LA       LVYGD       L R+HS C TGD   S RCDCGFQL+ +L  I E G G 
Sbjct: 70  LADMQQSSVLVYGDFENSEDALIRMHSICHTGDIFGSKRCDCGFQLKQSLQMITEHGSGA 129

Query: 86  LLY-HRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNE 144
           L Y    EGR IGL +K   Y LQ+ G DTVEAN  LGF  D R++    ++ K L    
Sbjct: 130 LFYLANHEGRGIGLFSKAMTYLLQENGLDTVEANLNLGFEDDVRNYDDTIEVLKALRSKP 189

Query: 145 VRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAEKMGHL 193
           V+L+TNNPKK+E L +AG+N+  R PL    +  NE YL TK ++ GH 
Sbjct: 190 VKLITNNPKKLEALQKAGLNVTSREPLWGDVSEFNEKYLQTKIQRSGHF 238


>UniRef50_A8FIW0 GTP cyclohydrolase-2 n=7 Tax=Bacillales RepID=A8FIW0_BACP2
          Length = 253

 Score =  144 bits (364), Expect = 1e-33,   Method: Compositional matrix adjust.
 Identities = 76/170 (44%), Positives = 97/170 (57%), Gaps = 1/170 (0%)

Query: 25  ELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQIAEEGRG 84
           +LA       LVYGD       L R+HS C TGD   S RCDCGFQL+ ++  I + G G
Sbjct: 72  QLADHQQSSVLVYGDFEHADEALIRMHSICHTGDIFGSKRCDCGFQLKQSMRMIEDNGAG 131

Query: 85  ILLY-HRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVN 143
            L Y    EGR IGL  K  AY LQ+ GYDTVEAN  LGF  D R +     + + L   
Sbjct: 132 ALFYLANHEGRGIGLFTKAMAYILQENGYDTVEANEALGFEDDTRQYEEAIAVLQTLRTK 191

Query: 144 EVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAEKMGHL 193
            VRL+TNNPKK + ++ AG+++  R+PL    +  NE YL TK  + GH+
Sbjct: 192 PVRLITNNPKKTDAISHAGLSLSGRIPLWGDVSEFNEKYLQTKINRSGHM 241


>UniRef50_Q3YT81 GTP cyclohydrolase-2 n=6 Tax=canis group RepID=Q3YT81_EHRCJ
          Length = 380

 Score =  144 bits (362), Expect = 2e-33,   Method: Compositional matrix adjust.
 Identities = 71/164 (43%), Positives = 105/164 (64%), Gaps = 2/164 (1%)

Query: 31  DHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQIAEEGRGILLYHR 90
           DH A++ G+     P++ R+HS C TGD L SL CDC  QL  A+  + E   GI+LY  
Sbjct: 203 DHYAIIIGNPDYSNPIV-RIHSSCYTGDLLNSLSCDCRCQLHTAIKLMTENKGGIILYLA 261

Query: 91  QEGRNIGLLNKIRAYALQDQ-GYDTVEANHQLGFAADERDFTLCADMFKLLGVNEVRLLT 149
           Q+GR IGL NKIR Y LQ +  +DTV+AN   GF  DER FT    + + LG++ ++LLT
Sbjct: 262 QDGRGIGLANKIRTYQLQTKHNFDTVDANRFFGFEDDERVFTPAIKILQKLGISRLQLLT 321

Query: 150 NNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAEKMGHL 193
           NNP K+  + +  I + + +P+ V  N +N +Y++TKA+++GH+
Sbjct: 322 NNPNKISEIQKNNIQVTKILPIFVDTNQHNINYINTKAKRLGHV 365


>UniRef50_B0UFT4 GTP cyclohydrolase-2 n=4 Tax=Rhizobiales RepID=B0UFT4_METS4
          Length = 370

 Score =  144 bits (362), Expect = 2e-33,   Method: Compositional matrix adjust.
 Identities = 90/197 (45%), Positives = 113/197 (57%), Gaps = 7/197 (3%)

Query: 3   LKRVAEAKLP---TPWGDFLMV-GFEELATGHDHVALVYGDISGHTPVLARVHSECLTGD 58
           L+ V+ A +P    P  +F++  G E L    D VA+V G      PV  RVHS CLTGD
Sbjct: 165 LQIVSRAPVPLDGAPETEFVVFRGGEGL---RDQVAVVIGRPDPAQPVAVRVHSACLTGD 221

Query: 59  ALFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEAN 118
              SL+CDCG QL      +A+ G GI+LY  QEGR  GL NKIRAYALQ +GYDT  A+
Sbjct: 222 LFGSLKCDCGDQLRGTAKWMAQNGGGIILYLDQEGRGNGLANKIRAYALQAKGYDTYAAD 281

Query: 119 HQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPN 178
             LGF  D+R F   A M + LGV  VR+L+NNP+KV  L  AG+ +V     +    P 
Sbjct: 282 EMLGFGLDQRRFDFAAAMLRCLGVASVRVLSNNPEKVAALAAAGLAVVGEQRALGRVTPE 341

Query: 179 NEHYLDTKAEKMGHLLN 195
           N  YL  K +  GH L+
Sbjct: 342 NARYLAAKRDVAGHALD 358


>UniRef50_A8NX34 GTP cyclohydrolase-2 n=2 Tax=Agaricales RepID=A8NX34_COPC7
          Length = 468

 Score =  143 bits (360), Expect = 4e-33,   Method: Compositional matrix adjust.
 Identities = 74/143 (51%), Positives = 93/143 (65%), Gaps = 15/143 (10%)

Query: 45  PVLARVHSECLTGDALFSLRCDCGFQLEAALTQIAEE------GRGILLYHRQEGRNIGL 98
           P L R+HSEC TG+ + S+RCDCG QL+ A+ QI+        GRG ++Y RQEGR IGL
Sbjct: 265 PPLIRIHSECFTGETVGSMRCDCGEQLDEAIRQISNPINSQIPGRGAVIYLRQEGRGIGL 324

Query: 99  LNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGV---------NEVRLLT 149
           L+KIRAY LQD G+DTV AN  LG  ADER + +   + K LG+           VR+LT
Sbjct: 325 LSKIRAYNLQDMGHDTVTANLMLGHKADERGYEIAGAILKDLGLGCGENASCSESVRILT 384

Query: 150 NNPKKVEILTEAGINIVERVPLI 172
           NNP K+E L + GI I ERVP+I
Sbjct: 385 NNPDKMEALRKEGIQISERVPMI 407


>UniRef50_P50139 GTP cyclohydrolase-2 n=33 Tax=Ascomycota RepID=RIB1_PICGU
          Length = 332

 Score =  142 bits (359), Expect = 5e-33,   Method: Compositional matrix adjust.
 Identities = 77/162 (47%), Positives = 101/162 (62%), Gaps = 10/162 (6%)

Query: 45  PVLARVHSECLTGDALFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRA 104
           P+LAR+HSEC TG+  +S RCDCG Q + A   + E G G ++Y RQEGR IGL  K++A
Sbjct: 167 PILARIHSECYTGETAWSARCDCGEQFDEAGRLMGEAGHGCIVYLRQEGRGIGLGEKLKA 226

Query: 105 YALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILT--EAG 162
           Y LQD G DTV+AN  L   AD R F+L   +   LG+NE++LLTNNP K+  +      
Sbjct: 227 YNLQDLGADTVQANLMLRHPADARSFSLATAILLDLGLNEIKLLTNNPDKIAAVEGRNRE 286

Query: 163 INIVERVPLI--VGRNPNN------EHYLDTKAEKMGHLLNK 196
           + +VERVP++    R+ N       E YL  K E+MGHLL K
Sbjct: 287 VKVVERVPMVPLAWRSENGIKSKEIEGYLSAKIERMGHLLEK 328


>UniRef50_B2GGU5 GTP cyclohydrolase-2 n=1 Tax=Kocuria rhizophila DC2201
           RepID=B2GGU5_KOCRD
          Length = 238

 Score =  142 bits (359), Expect = 5e-33,   Method: Compositional matrix adjust.
 Identities = 84/199 (42%), Positives = 108/199 (54%), Gaps = 6/199 (3%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFE----ELATGHDHVALVYGDISGHTPV--LARVHSECLT 56
           L+      +PT  G F +VG+       A   +HV+L     +G   +  L R+HSECLT
Sbjct: 32  LEHSEPVTVPTDHGTFSVVGWRVPERSGAPATEHVSLSAPPPAGEEKLAPLVRLHSECLT 91

Query: 57  GDALFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVE 116
           GD   S RCDCG QL  AL +I   G  +L     EGR IGL+NK+RAY LQD G DTV+
Sbjct: 92  GDVFGSWRCDCGPQLHLALERIHTHGGTVLYLRNHEGRGIGLVNKLRAYKLQDAGADTVD 151

Query: 117 ANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRN 176
           AN  LG  A+ RD+T  A +   + +  VRLLTNNP KV  L   GI + + +   V   
Sbjct: 152 ANTMLGLPAEARDYTAAARILTAMNLTTVRLLTNNPDKVSKLEALGITVADVLAHEVSPR 211

Query: 177 PNNEHYLDTKAEKMGHLLN 195
             N  YL TK ++M H L 
Sbjct: 212 TENVDYLRTKRDRMHHHLT 230


>UniRef50_B9KHB1 GTP cyclohydrolase-2 n=5 Tax=Anaplasma RepID=B9KHB1_ANAMF
          Length = 377

 Score =  138 bits (348), Expect = 9e-32,   Method: Compositional matrix adjust.
 Identities = 74/164 (45%), Positives = 101/164 (61%), Gaps = 2/164 (1%)

Query: 31  DHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQIAEEGRGILLYHR 90
           +H A++ GD S   PV+ R+HS C TGD L S+ CDC  QL   +  +     GI+LY  
Sbjct: 214 EHYAIIIGDPSFENPVV-RLHSSCYTGDLLGSISCDCRGQLLHTIQFLGSGSGGIVLYIS 272

Query: 91  QEGRNIGLLNKIRAYALQDQ-GYDTVEANHQLGFAADERDFTLCADMFKLLGVNEVRLLT 149
           QEGR IGL NKIRAY LQ Q   DTV+AN  LGF  DER F   A +   LG+++ ++LT
Sbjct: 273 QEGRGIGLANKIRAYNLQTQNALDTVDANRFLGFDDDERVFLPAARILDELGISKFQMLT 332

Query: 150 NNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAEKMGHL 193
           +NP KV  + + G  + + +PL VG +  N  Y+ TK E++GH+
Sbjct: 333 SNPSKVSSMCDHGFTVTKMIPLSVGTHERNIDYIKTKIERLGHV 376


>UniRef50_A6MYZ0 GTP cyclohydrolase-2 n=2 Tax=Saccharomycetaceae RepID=A6MYZ0_9SACH
          Length = 313

 Score =  136 bits (342), Expect = 5e-31,   Method: Compositional matrix adjust.
 Identities = 79/173 (45%), Positives = 101/173 (58%), Gaps = 16/173 (9%)

Query: 39  DISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGL 98
           D  G T  L R+HSEC TG+  +S RCDCG Q + A   I E G G+++Y RQEGR IGL
Sbjct: 108 DEDGDTGTLVRLHSECYTGETAWSARCDCGEQFDRAGRMIGESGSGVIVYLRQEGRGIGL 167

Query: 99  LNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKV-EI 157
             K++AY LQD G DTV+AN  L    D RDF+L   +   LG+  VRLLTNNP+K+ ++
Sbjct: 168 GEKLKAYNLQDLGADTVQANLLLKHPVDGRDFSLGRAILVDLGIKSVRLLTNNPQKLQQV 227

Query: 158 LTEAGINIVERVPLI--------------VG-RNPNNEHYLDTKAEKMGHLLN 195
                +  VERVP+I              VG R+   + YL  K E+MGHLL 
Sbjct: 228 HCPPLLTCVERVPMIPLSWIDGVREAGXEVGIRSKEVDAYLRVKMEQMGHLLQ 280


>UniRef50_Q5KNS2 GTP cyclohydrolase-2 n=1 Tax=Filobasidiella neoformans
           RepID=Q5KNS2_CRYNE
          Length = 550

 Score =  135 bits (340), Expect = 8e-31,   Method: Compositional matrix adjust.
 Identities = 82/226 (36%), Positives = 109/226 (48%), Gaps = 77/226 (34%)

Query: 47  LARVHSECLTGDALFSLRCDCGFQLEAALTQIAEE------------------------- 81
           L R+HSEC TG+ + S+RCDCG QL+ A+ QIAE                          
Sbjct: 320 LVRIHSECFTGETIGSMRCDCGEQLDEAIHQIAEPQRIPVPLVAPNSYSGDSFSTSAAFH 379

Query: 82  ----------GRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFT 131
                     GRG+++Y RQEGR IGLL KIRAY LQD G+DTV AN  LG  ADER + 
Sbjct: 380 PETTAYTHVPGRGVVIYLRQEGRGIGLLEKIRAYNLQDLGHDTVTANLMLGHGADERKYD 439

Query: 132 LCADMFKLLGVNE--VRLLTNNPKKVEILTEAGINIVERVPLI----------------- 172
           + A++ + LG+ +  +RLLTNNP+KV  L   G+ +VERV +                  
Sbjct: 440 IAAEILRDLGLADEGIRLLTNNPEKVRGLAREGVKVVERVGMTPRSWQCGDDHSHENKDG 499

Query: 173 -----------------------VGRNPNNEHYLDTKAEKMGHLLN 195
                                  +   P  E YL TK E+MGH+++
Sbjct: 500 AKEEKEYEDWRMRRAGVGLIGAGMASGPELEKYLRTKVERMGHIID 545


>UniRef50_Q4P4Y7 GTP cyclohydrolase-2 n=2 Tax=Basidiomycota RepID=Q4P4Y7_USTMA
          Length = 776

 Score =  135 bits (339), Expect = 1e-30,   Method: Composition-based stats.
 Identities = 67/142 (47%), Positives = 90/142 (63%), Gaps = 16/142 (11%)

Query: 47  LARVHSECLTGDALFSLRCDCGFQLEAALTQIAEE----------------GRGILLYHR 90
           L R+HSEC TG+ + S RCDCG QL+ A+  I+E                 GRG+++Y R
Sbjct: 452 LVRIHSECFTGETIGSQRCDCGEQLDEAIRLISEAYDTSKPRDPGAAQQKLGRGVIVYLR 511

Query: 91  QEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNEVRLLTN 150
           QEGR IGLL+K+ AY LQD G+DTV AN  LG   D R + + + + K LGV+E RLLTN
Sbjct: 512 QEGRGIGLLDKLMAYNLQDMGHDTVSANILLGHLPDARKYDIASAILKDLGVDECRLLTN 571

Query: 151 NPKKVEILTEAGINIVERVPLI 172
           NP+K+E L   G+ + ERV ++
Sbjct: 572 NPEKMEALEAEGVRVAERVGMV 593


>UniRef50_C7R1D1 3,4-dihydroxy-2-butanone 4-phosphate synthase n=1 Tax=Jonesia
           denitrificans DSM 20603 RepID=C7R1D1_JONDD
          Length = 411

 Score =  134 bits (338), Expect = 1e-30,   Method: Compositional matrix adjust.
 Identities = 74/149 (49%), Positives = 90/149 (60%), Gaps = 2/149 (1%)

Query: 49  RVHSECLTGDALFSLRCDCGFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYAL 107
           RVHSECLTGD   S RCDCG QL+ AL  IA    GI++Y R  EGR IGL +KIRAY L
Sbjct: 263 RVHSECLTGDVFASQRCDCGEQLDRALMHIATH-PGIVVYLRGHEGRGIGLFDKIRAYHL 321

Query: 108 QDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVE 167
           QD+GYDTV+AN  LGFA D+R +   A +   LG + V LLTNNP K   L   G+ +  
Sbjct: 322 QDEGYDTVDANTALGFAPDQRTWEHAAAILTALGASTVNLLTNNPAKQHGLEAHGVTVQG 381

Query: 168 RVPLIVGRNPNNEHYLDTKAEKMGHLLNK 196
              + +     N  Y+ TK  +M H LN 
Sbjct: 382 TTRIELPTTIYNADYMRTKKTRMDHQLNN 410


>UniRef50_C5LSF0 GTP cyclohydrolase II, putative (Fragment) n=1 Tax=Perkinsus
           marinus ATCC 50983 RepID=C5LSF0_9ALVE
          Length = 406

 Score =  133 bits (335), Expect = 3e-30,   Method: Compositional matrix adjust.
 Identities = 78/164 (47%), Positives = 99/164 (60%), Gaps = 7/164 (4%)

Query: 33  VALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQIAEEGRGILLYHR-Q 91
           V L+ G + G + V  R+HSEC TGD L S++CDCG QL   L  + EE R +LLY R  
Sbjct: 244 VTLIKGKVEGESNVPVRIHSECFTGDVLRSMKCDCGDQLLDFLVTLDEEERAVLLYIRGH 303

Query: 92  EGRNIGLLNKIRAYALQDQ-GYDTVEANHQLGFAADERDFTLCADMFKLLGVNEVRLLTN 150
           EGR IGL NK++AY LQD+ G DT+E+N +LG+A D RDF       + LG++ V L TN
Sbjct: 304 EGRGIGLANKVKAYNLQDEDGLDTIESNIRLGYAPDCRDFADARRALRHLGIHSVMLYTN 363

Query: 151 NPKKVEILTEAGINIVERVPLIVGR-NPNNEHYLDTKAEKMGHL 193
           NP KV  L +    +V  V  +  R N NN  YL TK  K  HL
Sbjct: 364 NPAKVAALGD----MVAEVKAVPARPNRNNIGYLRTKQSKFHHL 403


>UniRef50_A0Z3E0 GTP cyclohydrolase-2 n=1 Tax=marine gamma proteobacterium HTCC2080
           RepID=A0Z3E0_9GAMM
          Length = 272

 Score =  131 bits (329), Expect = 1e-29,   Method: Compositional matrix adjust.
 Identities = 79/178 (44%), Positives = 103/178 (57%), Gaps = 5/178 (2%)

Query: 23  FEELATGHD-HVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQIAEE 81
           F +LA+    +  L  GD       L RVHS CLTGD   S RC+CG QLEAA+ ++AEE
Sbjct: 91  FSQLASSMAVNSVLAIGDAETTESPLVRVHSNCLTGDVFGSRRCECGPQLEAAIDRLAEE 150

Query: 82  -GRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKL 139
            G G L+Y    EGR IGL  K   Y LQD+G DT +AN  LG   D RDF+  A + K 
Sbjct: 151 PGGGYLIYMAGHEGRGIGLWAKAATYLLQDEGEDTYQANRSLGLPDDSRDFSDAATLLKY 210

Query: 140 LGVNE-VRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAEKMGHLLNK 196
            G    +RLLTNNPKK++ L   G+  +ERV  + G + +N  YL  K +  GH +++
Sbjct: 211 FGRGRPLRLLTNNPKKIDDLLANGLTNIERVKHVTGVDDHNLRYLKAK-QAWGHSIDE 267


>UniRef50_C9S9H3 GTP cyclohydrolase-2 n=1 Tax=Verticillium albo-atrum VaMs.102
           RepID=C9S9H3_VERA1
          Length = 379

 Score =  130 bits (327), Expect = 2e-29,   Method: Compositional matrix adjust.
 Identities = 75/165 (45%), Positives = 97/165 (58%), Gaps = 13/165 (7%)

Query: 45  PVLARVHSECLTGDALFSLRCDCGFQLEAALTQIAEEGR---GILLYHRQEGRNIGLLNK 101
           P L R+HSEC TG+  +S RCDCG QL+ A   ++  G    GI++Y RQEGR IGL  K
Sbjct: 210 PPLVRIHSECYTGETAWSARCDCGEQLDEAARLMSLPGNHNGGIIIYLRQEGRGIGLGEK 269

Query: 102 IRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEA 161
           ++AY LQD G DTVEAN  L   AD R + L   M   LG +EVRLLTNNP K+  +   
Sbjct: 270 LKAYNLQDLGSDTVEANLLLRHPADARSYGLATAMLLDLGQDEVRLLTNNPDKIRAVEGP 329

Query: 162 G--INIVERVPLIV--------GRNPNNEHYLDTKAEKMGHLLNK 196
              + + ERV ++          ++   E YL TK EKMGH+L+ 
Sbjct: 330 NREVRVRERVAMVPLSWKGKGGFKSEEVEGYLKTKIEKMGHMLDS 374


>UniRef50_A6DFW0 GTP cyclohydrolase-2 n=1 Tax=Lentisphaera araneosa HTCC2155
           RepID=A6DFW0_9BACT
          Length = 361

 Score =  130 bits (327), Expect = 3e-29,   Method: Compositional matrix adjust.
 Identities = 77/187 (41%), Positives = 103/187 (55%), Gaps = 4/187 (2%)

Query: 9   AKLPTPWGDFLMVGFEELATGHDHVALVYGDIS--GHTPVLARVHSECLTGDALFSLRCD 66
            +L    G F +  F        H A V  +      TP L R+ SECLTG    SL CD
Sbjct: 174 TELDLQQGSFKLYSFYSEIDARYHWAFVCDEKKEEKKTP-LVRIESECLTGHVFGSLLCD 232

Query: 67  CGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQD-QGYDTVEANHQLGFAA 125
           CG QL   L +I E G G L+Y RQEGR IGL  K+ AY LQ   G DTV+AN  +G   
Sbjct: 233 CGDQLSKGLEEIKEYGYGALVYLRQEGRGIGLKAKLDAYYLQQFHGMDTVDANIAVGMPE 292

Query: 126 DERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDT 185
           D RD+ + A +   L    ++LLTNNP K+  L   G+++ ++V  I+  + +N+ YLDT
Sbjct: 293 DARDYLIGAQIINYLKFEPLKLLTNNPAKITGLNRYGLSVEQQVSHIIPPSKHNKRYLDT 352

Query: 186 KAEKMGH 192
           K ++MGH
Sbjct: 353 KRDRMGH 359


>UniRef50_P38066 GTP cyclohydrolase-2 n=8 Tax=Saccharomycetales RepID=RIB1_YEAST
          Length = 345

 Score =  129 bits (325), Expect = 4e-29,   Method: Compositional matrix adjust.
 Identities = 77/175 (44%), Positives = 101/175 (57%), Gaps = 21/175 (12%)

Query: 43  HTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQIAEE-----------GRGILLYHRQ 91
           H   L R+HSEC TG+  +S RCDCG Q + A   IA +           G G+++Y RQ
Sbjct: 137 HNDTLVRIHSECYTGENAWSARCDCGEQFDRAGRLIACDHEPTSNIKGGNGHGVIVYLRQ 196

Query: 92  EGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNN 151
           EGR IGL  K++AY LQD G DTV+AN  L    D RDF+L   +   LG+  VRLLTNN
Sbjct: 197 EGRGIGLGEKLKAYNLQDLGADTVQANLMLKHPVDARDFSLGKAILLDLGIGNVRLLTNN 256

Query: 152 PKKVEILTEAG-INIVERVPLIVGRNPNN---------EHYLDTKAEKMGHLLNK 196
           P+K++ +  A  +  VERVP++     N+         E YL TK E+MGHLL +
Sbjct: 257 PEKIKQVDHAPYLKCVERVPMVPIHWTNSSEGIDSKEIEGYLRTKIERMGHLLTE 311


>UniRef50_B8KSW9 GTP cyclohydrolase-2 n=1 Tax=gamma proteobacterium NOR51-B
           RepID=B8KSW9_9GAMM
          Length = 273

 Score =  123 bits (309), Expect = 3e-27,   Method: Compositional matrix adjust.
 Identities = 74/165 (44%), Positives = 95/165 (57%), Gaps = 4/165 (2%)

Query: 35  LVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQIA-EEGRGILLYHR-QE 92
           LV G+       L RVHS CLTGD   S RC+CG QLEAA+ +IA +E  G L+Y    E
Sbjct: 104 LVIGEPEKSEAPLVRVHSSCLTGDVFGSRRCECGPQLEAAIDRIATDEQGGYLIYMAGHE 163

Query: 93  GRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGV-NEVRLLTNN 151
           GR IGL  K   Y LQD G DT +AN  LG   D RDF+  A +    G   ++RL+TNN
Sbjct: 164 GRGIGLWAKAATYLLQDAGEDTYQANRSLGLPDDSRDFSDAATLLHYFGAGRKLRLMTNN 223

Query: 152 PKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAEKMGHLLNK 196
           PKK+E L   G+  +ERV  + G +  N  YL  K  + GH +++
Sbjct: 224 PKKIEDLRAFGVPNLERVKHVSGVDDCNLRYLQAK-RQWGHRIDE 267


>UniRef50_A1SF04 GTP cyclohydrolase-2 n=16 Tax=Bacteria RepID=A1SF04_NOCSJ
          Length = 215

 Score =  123 bits (308), Expect = 4e-27,   Method: Compositional matrix adjust.
 Identities = 74/170 (43%), Positives = 94/170 (55%), Gaps = 5/170 (2%)

Query: 23  FEELATGHDHVALVYGDIS---GHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQIA 79
           F  L    +H+ +  G      G  P L R+HSECLTGD   S RCDCG QL+ AL +IA
Sbjct: 34  FTGLPGAEEHLVVAVGPYRRPRGGVP-LVRLHSECLTGDVFGSRRCDCGPQLDEALVRIA 92

Query: 80  EEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKL 139
           E G G L+Y RQEGR IGL  K+ AY LQDQG DT EAN  LG+  D R + +   M + 
Sbjct: 93  EHG-GYLVYLRQEGRGIGLYAKLDAYRLQDQGLDTFEANRALGYPEDARGYEVAGRMLRA 151

Query: 140 LGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAEK 189
           L V +V L+T NP+K   L   G+ +   +P  +     N  YL  K  +
Sbjct: 152 LDVLQVDLMTGNPQKAAGLAAGGVAVRRTLPTALHETTENLRYLHAKRRR 201


>UniRef50_A8PZB1 GTP cyclohydrolase-2 n=1 Tax=Malassezia globosa CBS 7966
           RepID=A8PZB1_MALGO
          Length = 455

 Score =  122 bits (305), Expect = 9e-27,   Method: Compositional matrix adjust.
 Identities = 62/137 (45%), Positives = 85/137 (62%), Gaps = 11/137 (8%)

Query: 47  LARVHSECLTGDALFSLRCDCGFQLEAALTQIAEEGRGI-----------LLYHRQEGRN 95
           L R+HSEC TG+ + S RCDCG QL+ AL  I                  ++Y RQEGR 
Sbjct: 168 LVRIHSECYTGETIGSQRCDCGEQLDEALRIIGTSSSRTATGVPVPPRGVVVYMRQEGRG 227

Query: 96  IGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKV 155
           IGLL+K+ AY LQD G+DTV AN  LG   D R + + + + + LG+++ RLLTNNP+K+
Sbjct: 228 IGLLDKLLAYNLQDMGHDTVSANVLLGHLPDARRYDISSAILRDLGIDQCRLLTNNPEKM 287

Query: 156 EILTEAGINIVERVPLI 172
           + L   GI + ERVP++
Sbjct: 288 QALEAEGIRVTERVPMV 304


>UniRef50_Q14FW6 Riboflavin biosynthesis protein ribA/GTP-cyclohydrolase II n=20
           Tax=Proteobacteria RepID=Q14FW6_FRAT1
          Length = 403

 Score =  121 bits (304), Expect = 1e-26,   Method: Compositional matrix adjust.
 Identities = 77/196 (39%), Positives = 110/196 (56%), Gaps = 10/196 (5%)

Query: 3   LKRVAEAKLP-TPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALF 61
           + ++A + +P    G+  M  +++  +G D V ++    SG+ P L R+HS C+TGD   
Sbjct: 211 VTKMASSTIPFKKIGELEMSVYKDNFSG-DEVVVLSKPYSGNNP-LVRMHSSCITGDIFG 268

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQ-DQGYDTVEANHQ 120
           SLRCDC  QL   +  I+EEG G  +Y  QEGR IGL NK++AY LQ ++  DT+EAN  
Sbjct: 269 SLRCDCQDQLHKGIEMISEEG-GFFIYLDQEGRGIGLTNKLKAYNLQMNENMDTLEANLA 327

Query: 121 LGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGR--NPN 178
           LG  AD R + L   + K   VN  RL++NNP+K+  L    I   E  P+      N +
Sbjct: 328 LGLPADARKYDLAIQVLKYNNVNRCRLISNNPEKLAALRNVDI---ETQPVYCEAFVNSH 384

Query: 179 NEHYLDTKAEKMGHLL 194
           N +YL TK  K  H +
Sbjct: 385 NRNYLITKKIKAKHTI 400


>UniRef50_C5RMY3 GTP cyclohydrolase-2 n=1 Tax=Clostridium cellulovorans 743B
           RepID=C5RMY3_CLOCL
          Length = 175

 Score =  119 bits (298), Expect = 6e-26,   Method: Compositional matrix adjust.
 Identities = 56/141 (39%), Positives = 85/141 (60%), Gaps = 9/141 (6%)

Query: 26  LATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQIAEEGRGI 85
           ++   DH++L          +L R+HSEC   + L S+RCDC  QL+ +L +IA EG+G+
Sbjct: 37  VSLNQDHLSL--------NDILVRIHSECFMSEVLSSIRCDCASQLKESLKRIASEGQGV 88

Query: 86  LLYHRQEGRNIGLLNKIRAYALQDQ-GYDTVEANHQLGFAADERDFTLCADMFKLLGVNE 144
           L Y RQEG+ +GL NK +AY LQ++      EA+   GF  D RD+    ++   + ++ 
Sbjct: 89  LFYLRQEGKGMGLFNKAKAYYLQEKYQLSNYEADKMAGFPEDTRDYAFVVEVLNEMNIHS 148

Query: 145 VRLLTNNPKKVEILTEAGINI 165
           +RLLTNN +K+  L E GIN+
Sbjct: 149 IRLLTNNDEKIRYLKENGINV 169


>UniRef50_C0A9J6 GTP cyclohydrolase-2 n=1 Tax=Opitutaceae bacterium TAV2
           RepID=C0A9J6_9BACT
          Length = 516

 Score =  117 bits (292), Expect = 3e-25,   Method: Compositional matrix adjust.
 Identities = 76/196 (38%), Positives = 101/196 (51%), Gaps = 7/196 (3%)

Query: 6   VAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRC 65
           +A   L T +G F    F+++   H  +AL +GDI G T +  R+HS C+T + L    C
Sbjct: 40  LATCALDTRYGAFRAYVFQDITDKHYILALTHGDICGATTLHTRLHSSCVTSETLRGCDC 99

Query: 66  DCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIR----AYALQDQGYDTVEANHQL 121
           DC  QLE A   IA++G GIL Y  QEGR +G   K R      A QDQ   T +A   +
Sbjct: 100 DCTQQLEGAFKVIAQKGSGILFYLMQEGRGVGYFAKARDRMLVQASQDQ-LSTFDAYAAM 158

Query: 122 GFAADERDFTLCADMFKLLGVN-EVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNE 180
           G A D R++   + +  LLG+     LLTNNP K+E L   G+ I    PL     P N 
Sbjct: 159 GLAKDHRNYENISHICHLLGIRASFILLTNNPDKIEALRAQGLPIAGSEPLEFEPGPFNL 218

Query: 181 HYLDTKAEKMGHLLNK 196
            YL +KA   GH L +
Sbjct: 219 AYLTSKAAN-GHQLQR 233


>UniRef50_C9PF77 GTP cyclohydrolase II n=1 Tax=Vibrio furnissii CIP 102972
           RepID=C9PF77_VIBFU
          Length = 352

 Score =  116 bits (291), Expect = 4e-25,   Method: Compositional matrix adjust.
 Identities = 73/189 (38%), Positives = 104/189 (55%), Gaps = 11/189 (5%)

Query: 10  KLPTPWGDFLMVGFEELATGHDHVALV-YGDIS--GHTPVLARVHSECLTGDALFSLRCD 66
           +LPT  G F M       TG++   +V +GDIS  G  P++ R+HS CL  +   +  CD
Sbjct: 8   ELPTLHGTFRMYD-----TGNELFRVVTFGDISNLGSQPMV-RIHSSCLASEVFEARDCD 61

Query: 67  CGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRA-YALQDQGYDTVEANHQLGFAA 125
           C  QL  A+  +A +G GI+ +  QEGR  GL  KI+A Y +Q +  DT E+   +G   
Sbjct: 62  CADQLREAMKAMAHDGSGIIFHLHQEGRGQGLSKKIQAVYKMQVEALDTAESFQAMGLEQ 121

Query: 126 DERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDT 185
           D RD+     + K + + EVRL++NNP+K   L +AGI  VE V       P N  YL +
Sbjct: 122 DIRDYEPAISVLKKMAIEEVRLVSNNPRKRSALEQAGI-AVEVVNTHPQVRPENAGYLQS 180

Query: 186 KAEKMGHLL 194
           K +K+GH L
Sbjct: 181 KNDKLGHYL 189


>UniRef50_A5ARE3 Putative uncharacterized protein n=1 Tax=Vitis vinifera
           RepID=A5ARE3_VITVI
          Length = 480

 Score =  115 bits (287), Expect = 1e-24,   Method: Compositional matrix adjust.
 Identities = 67/192 (34%), Positives = 100/192 (52%), Gaps = 40/192 (20%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           ++R A ++LPT WG F    +     G +HVA+V                          
Sbjct: 322 VERTAISRLPTKWGLFQAYCYRSKLDGTEHVAIV-------------------------- 355

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
                          + + GRG+++Y R  EGR IGL +K+RAY LQD+G+DTVEAN +L
Sbjct: 356 -------------KLVEQAGRGVVVYLRGHEGRGIGLGHKLRAYNLQDEGHDTVEANLEL 402

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181
           G A D R++ + A + + +GV  ++L+TNNP K   L   G+ +V RVP++      N+ 
Sbjct: 403 GLAVDAREYGIGAQILRDIGVRTMQLMTNNPAKFTGLKGYGLAVVGRVPVLTPITEENKK 462

Query: 182 YLDTKAEKMGHL 193
           YL+TK  KMGH+
Sbjct: 463 YLETKRTKMGHI 474


>UniRef50_Q5YVN1 GTP cyclohydrolase-2 n=1 Tax=Nocardia farcinica RepID=Q5YVN1_NOCFA
          Length = 256

 Score =  114 bits (286), Expect = 1e-24,   Method: Compositional matrix adjust.
 Identities = 76/182 (41%), Positives = 95/182 (52%), Gaps = 6/182 (3%)

Query: 16  GDFLMVGFEELATGHDHVA-LVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAA 74
           G  L V   EL    D  + LV+G+I      L R+HS CL GDAL S  CDCG +LE +
Sbjct: 18  GAELTVRVRELPADRDGGSVLVFGEIGQD--CLVRIHSRCLYGDALQSDDCDCGPELERS 75

Query: 75  LTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQ-GYDTVEANHQLGFAADERDFTLC 133
           +  I  EGRG+L+Y  QEGR  GL+ K R     ++ G DT  A  +LG+  D R F L 
Sbjct: 76  MDLIQAEGRGVLVYLDQEGRGAGLVAKARGLREAERTGADTFTAYTRLGYPEDARSFRLA 135

Query: 134 ADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIV-GRNPNNEHYLDTKAEKMGH 192
           A     LG+  VRLLTNNP K   LT+ G+ +   VPL    R+     YL  K     H
Sbjct: 136 AAAIAELGLRRVRLLTNNPDKAAALTDLGVAVTV-VPLTTRPRSARARKYLQDKRAHRRH 194

Query: 193 LL 194
            L
Sbjct: 195 WL 196


>UniRef50_A8FAX3 GTP cyclohydrolase-2 n=2 Tax=Bacillus pumilus RepID=A8FAX3_BACP2
          Length = 241

 Score =  113 bits (283), Expect = 3e-24,   Method: Compositional matrix adjust.
 Identities = 66/164 (40%), Positives = 95/164 (57%), Gaps = 4/164 (2%)

Query: 35  LVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQIAEEGRGILLYH-RQEG 93
           L++GD     P L R+HS C TGD   SL+CDCG QL  +L +I + G+G+L+Y   QEG
Sbjct: 74  LLFGDFENEMPPLVRIHSVCQTGDVFGSLKCDCGPQLALSLKKITDYGKGMLVYMANQEG 133

Query: 94  RNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNE-VRLLTNNP 152
           R+IGL+ K   Y LQ+   DT EAN  +G   D+R +   A +   L   + + LLTNNP
Sbjct: 134 RSIGLMAKALTYKLQEMQLDTFEANRLIGCGDDDRHYEEAAAVLHYLNKGKPMHLLTNNP 193

Query: 153 KKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAEKMGHLLNK 196
            KV+ +   G+ ++ R    V  +  NE YL  KA   GH++++
Sbjct: 194 DKVDSIAAYGLPVL-RFDHTVEASLYNEAYLKAKAAS-GHMVDE 235


>UniRef50_Q2S6L1 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
           n=5 Tax=Bacteria RepID=Q2S6L1_SALRD
          Length = 415

 Score =  106 bits (264), Expect = 4e-22,   Method: Compositional matrix adjust.
 Identities = 64/172 (37%), Positives = 95/172 (55%), Gaps = 8/172 (4%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           ++R AE  L T +G F +V +EE  TG  H+AL+ GD +   PVL RVHS+ + GD L +
Sbjct: 219 IERAAEVDLDTAFGTFQVVAYEETLTGDVHLALLKGDWAEDEPVLVRVHSQNVLGDVLAA 278

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIR---AYALQDQGYDTVEANH 119
            R     +L  AL Q+  EG G +LY  Q     GLL+K++    +  QD G  T     
Sbjct: 279 RRESYSEELAEALLQVEHEGTGAILYMMQSNHGQGLLSKLKDLERHQNQDDGAPT----- 333

Query: 120 QLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPL 171
            +    D RD+ +   + + LG+ ++RLLTNNP+K   L   G+ +VE+ P+
Sbjct: 334 DVSLEMDHRDYGIGCQILRDLGIRKLRLLTNNPRKRIGLAGYGLELVEQTPI 385


>UniRef50_Q0D0K3 GTP cyclohydrolase-2 n=29 Tax=Leotiomyceta RepID=Q0D0K3_ASPTN
          Length = 447

 Score =  102 bits (254), Expect = 7e-21,   Method: Compositional matrix adjust.
 Identities = 63/153 (41%), Positives = 83/153 (54%), Gaps = 27/153 (17%)

Query: 47  LARVHSECLTGDALFSLRCDCGFQLEAA----------LTQIAEEGR---------GILL 87
           L R+HSEC TG+  +S RCDCG QL+ A          L ++A +           G+++
Sbjct: 231 LVRIHSECYTGETAWSARCDCGEQLDEAARLMSLPMETLAEVASQQSRTVPSNASGGVII 290

Query: 88  YHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGV----- 142
           Y RQEGR IGL  K++AY LQD G DTVEAN  L   AD R + L   M   LG+     
Sbjct: 291 YLRQEGRGIGLGEKLKAYNLQDLGSDTVEANLLLRHPADARSYGLATAMLVDLGLGVDAN 350

Query: 143 -NEVRLLTNNPKKVEILTEAGINIV--ERVPLI 172
            + +RLLTNNP KV  +      +V  ERV ++
Sbjct: 351 PHGIRLLTNNPDKVRAVEGPNREVVVKERVAMV 383


>UniRef50_A2TRN2 GTP cyclohydrolase-2 n=1 Tax=Dokdonia donghaensis MED134
           RepID=A2TRN2_9FLAO
          Length = 170

 Score =  100 bits (248), Expect = 4e-20,   Method: Compositional matrix adjust.
 Identities = 56/162 (34%), Positives = 87/162 (53%), Gaps = 4/162 (2%)

Query: 5   RVAEAKLPTPWGDFLMVGFEE-LATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSL 63
           ++A+  + T +G +  + F + +   H   ALV GDISG   VL RVHS C+      S+
Sbjct: 4   QLADGTIKTKYGIYKEILFYDGIKESH---ALVMGDISGEEDVLCRVHSSCIFAHHFNSI 60

Query: 64  RCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGF 123
            CDC  Q+E +   I   G+GI+++  QEG+  G    +    L+ +G    +A   +GF
Sbjct: 61  ECDCREQMEISQQLIERAGKGIVIWLEQEGKGNGHYALLNTLPLKKEGMPQADAYEAVGF 120

Query: 124 AADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINI 165
             D RDF+  A + K L VN + ++T N KK + LT+ GI +
Sbjct: 121 HKDNRDFSAAAKILKHLEVNSITMITGNEKKTKTLTDLGIRV 162


>UniRef50_Q08VV8 GTP cyclohydrolase-2 n=1 Tax=Stigmatella aurantiaca DW4/3-1
           RepID=Q08VV8_STIAU
          Length = 356

 Score = 98.2 bits (243), Expect = 1e-19,   Method: Compositional matrix adjust.
 Identities = 64/150 (42%), Positives = 75/150 (50%), Gaps = 5/150 (3%)

Query: 49  RVHSECLTGDALFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQ 108
           R+HS C+T +A     CDC  QLE AL +IAE GRG + Y  QEGR  G   K R   L 
Sbjct: 2   RIHSACITSEAFGGCDCDCAEQLELALERIAEAGRGAVFYLMQEGRGAGYAAKARDRMLV 61

Query: 109 DQGYDTV---EANHQLGFAADERDFTLCADMFKLLGVN-EVRLLTNNPKKVEILTEAGIN 164
               DTV   EA   LG   D R +   A    LL V   VRLLTNNP+K   L   GI 
Sbjct: 62  QASCDTVSTFEAYRMLGLEPDSRRYHEVALALGLLKVRAPVRLLTNNPEKTRALKTLGIE 121

Query: 165 IVERVPLIVGRNPNNEHYLDTKAEKMGHLL 194
           +     +    NP N HYL +K  + GH L
Sbjct: 122 VEAAERIQREANPFNVHYLSSK-RREGHAL 150


>UniRef50_Q6KH48 GTP cyclohydrolase-2 n=1 Tax=Mycoplasma mobile RepID=Q6KH48_MYCMO
          Length = 343

 Score = 97.4 bits (241), Expect = 2e-19,   Method: Compositional matrix adjust.
 Identities = 61/184 (33%), Positives = 98/184 (53%), Gaps = 4/184 (2%)

Query: 11  LPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQ 70
           + T  G F M  FE  +   + V    GD+     V AR+H +C+T +   S+ CDC  Q
Sbjct: 162 METSDGFFNMKSFEVPSHNKEFVIKWNGDLK--KIVNARIHYKCMTSEVFGSIMCDCKDQ 219

Query: 71  LEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYA-LQDQGYDTVEANHQLGFAADERD 129
           LE+    + +EG G+LLY  +EGR  G+L+K+ AY   + +G DTV+A  +     + R 
Sbjct: 220 LESFNELMKKEG-GLLLYAYEEGRGFGMLHKLNAYYNTEKEGLDTVDAMIKETGKTEARK 278

Query: 130 FTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAEK 189
           F +  ++ + LG+ EV L TNNP+K+  L +  I +  +      ++   + Y + K +K
Sbjct: 279 FDMAGEIIRKLGIKEVNLYTNNPRKIIPLLDRRIKVNRKKHWTETKSKEAKKYTEDKIKK 338

Query: 190 MGHL 193
           M HL
Sbjct: 339 MEHL 342


>UniRef50_D0L7U8 3,4-dihydroxy-2-butanone 4-phosphate synthase n=1 Tax=Gordonia
           bronchialis DSM 43247 RepID=D0L7U8_GORB4
          Length = 418

 Score = 97.4 bits (241), Expect = 2e-19,   Method: Compositional matrix adjust.
 Identities = 71/203 (34%), Positives = 105/203 (51%), Gaps = 13/203 (6%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPV----LARVHSECLTGD 58
           + +VA A +PT +GDF  V +     G +H+AL+ GD++  +      L RVHSECLTGD
Sbjct: 215 VAQVASAAMPTAFGDFRAVAYRCELDGTEHLALLMGDLAAASRTDRGALVRVHSECLTGD 274

Query: 59  ALFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEAN 118
            L SLRCDCG QLE AL+ IAEEG G ++Y R   R  G + + R+   + +   +  + 
Sbjct: 275 ILGSLRCDCGSQLEQALSAIAEEGCGAVVYLRGM-RAAGSVWRTRSAPTRCRNRVSTPST 333

Query: 119 HQLGFAADERDFTLCADMFKLLG--VNEVRLLTNNP---KKVEILTEAGINIVERVPLIV 173
               +      +   A ++ L     +E     ++P   +K   L    + IV R  L  
Sbjct: 334 PTPRWGC---RWIPAATVWVLRSSPTSEPGGSASSPTTRQKYGGLEGFDLEIVGRFGLPT 390

Query: 174 GRNPNNEHYLDTKAEKMGHLLNK 196
              P+N  YL TK E+MGH L++
Sbjct: 391 VITPHNVRYLRTKQERMGHTLDQ 413


>UniRef50_Q59AD7 GTP cyclohydrolase-2 (Fragment) n=2 Tax=Buchnera aphidicola
          RepID=Q59AD7_9ENTR
          Length = 81

 Score = 96.7 bits (239), Expect = 4e-19,   Method: Compositional matrix adjust.
 Identities = 43/81 (53%), Positives = 63/81 (77%), Gaps = 6/81 (7%)

Query: 16 GDFLMVGFEELAT--GHDHVALVYGDIS----GHTPVLARVHSECLTGDALFSLRCDCGF 69
          G+F ++GFEE++     +HVAL+YG+I+     +  VL R+HSECLTGDALFSLRCDCGF
Sbjct: 1  GEFTLIGFEEISKLEKKNHVALIYGNINLLILKNKAVLVRIHSECLTGDALFSLRCDCGF 60

Query: 70 QLEAALTQIAEEGRGILLYHR 90
          QL+ ++  I+++G G+++YHR
Sbjct: 61 QLKQSMKIISKKGFGVIIYHR 81


>UniRef50_A0SNY3 Riboflavin biosynthesis protein RibA n=2 Tax=Candidatus
           Micrarchaeum acidiphilum ARMAN-2 RepID=A0SNY3_9EURY
          Length = 290

 Score = 89.4 bits (220), Expect = 6e-17,   Method: Compositional matrix adjust.
 Identities = 64/215 (29%), Positives = 103/215 (47%), Gaps = 20/215 (9%)

Query: 1   MQLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGH-------TPVLARVHSE 53
           +Q+ R+    + TP+G F    FE      ++  LV   +            +L R+ S 
Sbjct: 74  VQVTRLGLGPIDTPFGKFYEFEFEVGDRWKEYNVLVKAGLDDKFNPQFEDGKILVRMDSA 133

Query: 54  CLTGDALFSLRCDCGFQLEAALTQIAEEGRGILLYH-RQEGRNIGLLNKIRAYALQDQ-G 111
           C TG       CDC  QL  A+ +I + G G++++  +Q+GR +GL  K+    LQD+ G
Sbjct: 134 CKTGQLFHDKTCDCKLQLLKAMHEIEKNGSGMIVHMPKQDGRGMGLSFKLGTLMLQDELG 193

Query: 112 YDTVEANHQLGF-------AADERDFTLCADMFKLLGVN---EVRLLTNNPKKVEILTEA 161
           Y+TVEA   L         A D R +     + +  G++   ++ + TNNPKK++   E 
Sbjct: 194 YNTVEAAAALKSMEFIEPEALDPRTYGGVIAILRFFGIDSGFDINVATNNPKKIQAFQEN 253

Query: 162 GINIVERVPLIVGRNPNNEHYLDTKAEKMGHLLNK 196
           G + V R P+I+  N   + +LD K E   H L +
Sbjct: 254 GYD-VGRTPVIIPPNEYTKRHLDAKEETFHHDLRR 287


>UniRef50_Q1AV39 GTP cyclohydrolase-2 n=1 Tax=Rubrobacter xylanophilus DSM 9941
           RepID=Q1AV39_RUBXD
          Length = 152

 Score = 82.0 bits (201), Expect = 9e-15,   Method: Compositional matrix adjust.
 Identities = 38/87 (43%), Positives = 55/87 (63%)

Query: 2   QLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALF 61
           +L+R AEA+LPT +G+F +V + +   G  H+ALV G++ G   V A +H  CL G+A  
Sbjct: 18  RLRREAEARLPTRFGEFRVVAYRDAVDGRAHLALVAGEVRGRGRVFAHIHRSCLLGEAFG 77

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLY 88
           SL C CG  LE A+ +   EGRG++ Y
Sbjct: 78  SLGCGCGALLEGAMQRAQREGRGVIAY 104


>UniRef50_A9QS81 GTP cyclohydrolase-2 n=1 Tax=Lactococcus lactis subsp. lactis KF147
           RepID=A9QS81_LACLK
          Length = 209

 Score = 78.2 bits (191), Expect = 1e-13,   Method: Compositional matrix adjust.
 Identities = 61/197 (30%), Positives = 90/197 (45%), Gaps = 7/197 (3%)

Query: 2   QLKRVAEAKLPTPWGDFLMVGFEELATGH--DHVALVYG-DISGHTPVLARVHSECLTGD 58
           ++ +V++ +L    G F +  F     G   +H ALV   D      V  R++S C+T +
Sbjct: 9   KILKVSKGQLEIKNGVFTLYAFMIYYEGRCEEHYALVNSKDWKIDEAVPFRINSACVTSE 68

Query: 59  ALFSLRCDCGFQLEAALTQIAEEGRGILLYH-RQEGRNIGLLNKIRAYALQDQGYDTVEA 117
                +CDC +QL+ A+  I E G GI+ YH   EG   G+  K+ ++   + G D    
Sbjct: 69  VFGCEKCDCKWQLDEAIHYITEIGFGIITYHPNHEGLGHGIFEKLNSF--NELGADNTSY 126

Query: 118 NHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIV-GRN 176
                   D R+F     +     +NEV LL NN KK+  L E G+NI   V LI  G N
Sbjct: 127 IDLNCEKEDARNFLPALIILDYFKINEVTLLGNNLKKIHFLMENGVNISGIVNLIYNGNN 186

Query: 177 PNNEHYLDTKAEKMGHL 193
              + Y+  K  K  H 
Sbjct: 187 RTTKKYILLKGRKPEHF 203


>UniRef50_Q1AZ21 GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate
           synthase n=2 Tax=Bacteria RepID=Q1AZ21_RUBXD
          Length = 366

 Score = 73.6 bits (179), Expect = 3e-12,   Method: Compositional matrix adjust.
 Identities = 36/83 (43%), Positives = 53/83 (63%)

Query: 6   VAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRC 65
           + E  LPT +G+F +  +  ++TG  H AL+ G+   + P L  V + C TGDAL SLRC
Sbjct: 209 LGEEALPTRFGEFRLRSYAGVSTGLIHRALLAGEPGENGPPLVGVRAACPTGDALHSLRC 268

Query: 66  DCGFQLEAALTQIAEEGRGILLY 88
           DCG +L  A+ ++A EG G++LY
Sbjct: 269 DCGERLRDAMERVAAEGEGVILY 291


>UniRef50_Q9R6K1 GTP cyclohydrolase-2 n=1 Tax=Agrobacterium tumefaciens
           RepID=Q9R6K1_RHIRD
          Length = 190

 Score = 73.2 bits (178), Expect = 5e-12,   Method: Compositional matrix adjust.
 Identities = 45/143 (31%), Positives = 72/143 (50%), Gaps = 5/143 (3%)

Query: 31  DHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQIAEEGRGILLYH- 89
           DH+A  Y  I    P+  R+ S C+ G       CDC  QL+ +L  I  +  G+++Y  
Sbjct: 51  DHLAF-YKSIG--VPLTLRIQSGCVLGHVFGDNECDCKAQLDKSLRYIHSQNEGMVIYTP 107

Query: 90  RQEGRNIGLLNKIRAY-ALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNEVRLL 148
             + R  G+ +K++ Y   Q++  D+  A  + G   D RDF+  + +  +  V  V LL
Sbjct: 108 SHDARGRGIYSKLQIYRTRQERCIDSAAACRETGVPFDTRDFSQFSSILGVFDVKSVALL 167

Query: 149 TNNPKKVEILTEAGINIVERVPL 171
             +  K + L EAGI++V  VPL
Sbjct: 168 GRSAAKAKALIEAGISVVSSVPL 190


>UniRef50_A6G9U6 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
           n=1 Tax=Plesiocystis pacifica SIR-1 RepID=A6G9U6_9DELT
          Length = 383

 Score = 72.0 bits (175), Expect = 1e-11,   Method: Compositional matrix adjust.
 Identities = 54/148 (36%), Positives = 69/148 (46%), Gaps = 33/148 (22%)

Query: 33  VALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQIAEEGRGILLYHRQE 92
           +AL  GD+SG  PVL R     L GD +F    D   +L A+L +I EEGRG  LY    
Sbjct: 247 IALTKGDLSGDDPVLLRAQRAQLVGD-VFGFGDDSATRLRASLARIDEEGRGAFLY---- 301

Query: 93  GRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADE--------------RDFTLCADMFK 138
                         L   GYD VEA   L     E              RDF L A + K
Sbjct: 302 -------------VLGGSGYD-VEAELHLAGERGELPEAPGLRPRESGFRDFGLGAQVLK 347

Query: 139 LLGVNEVRLLTNNPKKVEILTEAGINIV 166
            +GV+++R+LTNNP+K+  L   GI +V
Sbjct: 348 HMGVSKIRVLTNNPRKIVGLEGFGIEVV 375


>UniRef50_A0PS46 Riboflavin biosynthesis protein RibA1 n=16 Tax=Corynebacterineae
           RepID=A0PS46_MYCUA
          Length = 365

 Score = 70.9 bits (172), Expect = 3e-11,   Method: Compositional matrix adjust.
 Identities = 40/103 (38%), Positives = 57/103 (55%), Gaps = 5/103 (4%)

Query: 2   QLKRVAEAKLPTPWGDFLMVGFEELAT---GHDHVALVYGDISGHTPVLARVHSECLTGD 58
           Q+ R+ E  LPT  G+  ++GF +L     G +H+A+V G      PV   VH ECLTGD
Sbjct: 201 QVIRLTETTLPTWAGNSRVIGFRDLGPANPGGEHLAVVIGAPDSGVPVALHVHIECLTGD 260

Query: 59  ALFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEG--RNIGLL 99
              S  C CG +L  AL+ ++ +G G++LY +  G  R  GL 
Sbjct: 261 VFGSTGCRCGGELNGALSAMSAQGSGVVLYLQPPGPPRACGLF 303


>UniRef50_A0SNY4 Riboflavin biosynthesis protein RibA n=2 Tax=Candidatus
           Micrarchaeum acidiphilum ARMAN-2 RepID=A0SNY4_9EURY
          Length = 251

 Score = 63.9 bits (154), Expect = 3e-09,   Method: Compositional matrix adjust.
 Identities = 48/176 (27%), Positives = 78/176 (44%), Gaps = 14/176 (7%)

Query: 1   MQLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDI--SGHTPVLAR-------VH 51
            +++R+A   + T +G+F++  F+      D+  LV          P+  R         
Sbjct: 43  FEVRRIAVGPIITRFGNFMIYEFKINDRWKDYEVLVNAKAFDKDFMPLFERGRELLIKTD 102

Query: 52  SECLTGDALFSLRCDCGFQLEAALTQIAEEGRG-ILLYHRQEGRNIGLLNKIRAYALQDQ 110
           S C TG+      C C  QL +A+  I + G G I+    QEGR  G   K     LQ +
Sbjct: 103 SGCRTGEIYLDRTCTCRQQLHSAMETIGKRGNGLIITIPNQEGRGHGYAKKYATLVLQKE 162

Query: 111 -GYDTVEANHQLGFAADERDFTLCADMFKLLGVNE---VRLLTNNPKKVEILTEAG 162
            GYDT EA+  +    D RD+     + K  G+ +   + ++ NN  K++ + E G
Sbjct: 163 LGYDTYEASKAVNKKVDVRDYYGAVAILKFFGIGQSHRLEVIANNNSKLKEVLENG 218


>UniRef50_C5FIC6 GTP cyclohydrolase-2 n=1 Tax=Microsporum canis CBS 113480
           RepID=C5FIC6_NANOT
          Length = 519

 Score = 63.2 bits (152), Expect = 5e-09,   Method: Compositional matrix adjust.
 Identities = 39/128 (30%), Positives = 64/128 (50%), Gaps = 7/128 (5%)

Query: 49  RVHSECLTGDALFSLRCDCG----FQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRA 104
           R+H EC   D   S  C C     F +E A+ +  + G G+++Y R+EGR +G + K   
Sbjct: 338 RIHDECNGSDVFGSDICTCRPYLIFGVEEAVKEAQKGGSGVVIYFRKEGRALGEVTKYLV 397

Query: 105 YALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNEV-RLLTNNPKKVEILTEAGI 163
           Y  +   Y   +    +    D R   L  D+   LG+ ++ R+L+ +  K + + E GI
Sbjct: 398 YNARASEY--FKRTENIAGVKDMRFQALMPDILHWLGITKIDRMLSMSNMKHDAIVEQGI 455

Query: 164 NIVERVPL 171
            I+ERVP+
Sbjct: 456 PILERVPI 463


>UniRef50_Q6MIV8 GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate
           synthase n=1 Tax=Bdellovibrio bacteriovorus
           RepID=Q6MIV8_BDEBA
          Length = 376

 Score = 61.6 bits (148), Expect = 2e-08,   Method: Compositional matrix adjust.
 Identities = 46/162 (28%), Positives = 75/162 (46%), Gaps = 9/162 (5%)

Query: 11  LPTPWGDFLMVG-FEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGF 69
           LP  +G+ +    F     G +H+ +  G+I    P L RVH +  T D +  ++     
Sbjct: 216 LPASFGENMQARVFRSTVDGLEHLVIQKGEIKKDHPTLVRVHVDNFTRDFMAVVQRGASS 275

Query: 70  QLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERD 129
            LE+ +  I++E  G  +  R   R  GL  ++        G + +     L    DERD
Sbjct: 276 VLES-IKAISQEESGAFVLLRGNNRTSGLTQELNVLV----GLEDIRPTTPL---MDERD 327

Query: 130 FTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPL 171
           + + A + + +G N++RLLTN P+K   L    I IVE V +
Sbjct: 328 YGIGAQILREIGANKIRLLTNKPEKKVGLKAFDIEIVEIVAM 369


>UniRef50_D0NXG3 Putative uncharacterized protein n=1 Tax=Phytophthora infestans
           T30-4 RepID=D0NXG3_PHYIN
          Length = 459

 Score = 61.2 bits (147), Expect = 2e-08,   Method: Compositional matrix adjust.
 Identities = 45/144 (31%), Positives = 69/144 (47%), Gaps = 12/144 (8%)

Query: 40  ISGHTPVLA-RVHSECLTGDALFSLRCDC----GFQLEAALTQIAEEGRGILLYHRQEGR 94
           IS  T  LA RVH EC   D   S  C C       +E  +    E G GI++Y R+EGR
Sbjct: 267 ISDPTKKLAVRVHDECNGSDVFGSDICTCRPYLAHGIEVCVQTAQEGGAGIIVYFRKEGR 326

Query: 95  NIGLLNKIRAYAL--QDQGYDTVE----ANHQLGFAADERDFTLCADMFKLLGVNEV-RL 147
            +G + K   Y L  + +G D+ E        +    D R   L  D    LG+ ++ + 
Sbjct: 327 ALGEVTKYLVYNLRKRQEGGDSAEEYFNCTQTVAGIQDVRFQALMPDALHWLGITKIDKF 386

Query: 148 LTNNPKKVEILTEAGINIVERVPL 171
           ++ +  K + + ++GI IVER+P+
Sbjct: 387 VSMSDMKYDAIVKSGIEIVERIPI 410


>UniRef50_C0YN89 3,4-dihydroxy-2-butanone-4-phosphate synthase n=1
           Tax=Chryseobacterium gleum ATCC 35910 RepID=C0YN89_9FLAO
          Length = 373

 Score = 60.5 bits (145), Expect = 3e-08,   Method: Compositional matrix adjust.
 Identities = 41/150 (27%), Positives = 67/150 (44%), Gaps = 5/150 (3%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           ++R+ E K+ T +GDF    F E +    H AL  G  +   PVL RV S     D L  
Sbjct: 210 VERIEERKVKTFYGDFDFYAFRETSNEQIHFALTKGAWTVDEPVLVRVQSSDSYFDVLTR 269

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
           L       LE     + E G+G +++      +   L K++ +      Y   +  H   
Sbjct: 270 LNNGEKPLLEKVTNMVNEAGKGAIIFINNVSNSENTLRKLQQFL----NYQDGQEQHPT- 324

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNP 152
            A + RD+ +   + K LG+N+ +++T NP
Sbjct: 325 LAYNYRDYGIGTQILKNLGINKFKVITQNP 354


>UniRef50_B5JMM0 3,4-dihydroxy-2-butanone 4-phosphate synthase family n=1
           Tax=Verrucomicrobiae bacterium DG1235 RepID=B5JMM0_9BACT
          Length = 360

 Score = 60.5 bits (145), Expect = 3e-08,   Method: Compositional matrix adjust.
 Identities = 50/166 (30%), Positives = 75/166 (45%), Gaps = 21/166 (12%)

Query: 6   VAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRC 65
           + E    +  G+F M  F  L  G +HVALV G+I   T  L RVH+E +  D       
Sbjct: 216 IREQPFSSVHGEFSMKVFRSLLDGREHVALVAGEICSET-TLVRVHAENVVKDLFHPSDA 274

Query: 66  DCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAA 125
                +  A+ +IAEEG G ++Y R+ G   GL N                 +  +G   
Sbjct: 275 GAEDSIGLAMKRIAEEGCGAIVYIRRPGG--GLANS--------------PEDKSMGL-- 316

Query: 126 DERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPL 171
             R++ + A +   LG+ ++RLL+   + V  L   G+ IVE V L
Sbjct: 317 --REYGIGAQILSSLGLQKIRLLSQTNRNVIALDGYGLEIVETVGL 360


>UniRef50_C6X067 3,4-dihydroxy-2-butanone 4-phosphate synthase / GTP cyclohydrolase
           II n=1 Tax=Flavobacteriaceae bacterium 3519-10
           RepID=C6X067_FLAB3
          Length = 416

 Score = 60.1 bits (144), Expect = 4e-08,   Method: Compositional matrix adjust.
 Identities = 44/169 (26%), Positives = 74/169 (43%), Gaps = 5/169 (2%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           ++R+ E K+ T +GDF    F+E +T   H AL  G      PVL RV +     D L  
Sbjct: 253 IERIEERKVKTHYGDFDFFAFKETSTDQIHFALTKGTWVVDEPVLVRVQASNAYFDVLSR 312

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
           L       LE     I EEG+G L++          L K++ +     G +      +  
Sbjct: 313 LTAGEKPLLEKVTNMINEEGKGALIFINNVSTAENTLRKLQQFIDFQDGQE-----KRPT 367

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPL 171
            A++  D+ +   + K LG+ + R++T N  +  ++    + + E V L
Sbjct: 368 LASNFHDYGIGTQILKNLGITKFRVITQNVNQKPLVGGYDVEVTEMVQL 416


>UniRef50_A6DFW1 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
           n=1 Tax=Lentisphaera araneosa HTCC2155
           RepID=A6DFW1_9BACT
          Length = 360

 Score = 58.5 bits (140), Expect = 1e-07,   Method: Compositional matrix adjust.
 Identities = 49/168 (29%), Positives = 82/168 (48%), Gaps = 15/168 (8%)

Query: 11  LPTPWGDFLMVGFEEL---ATGHDHVALVYGD-ISGHTPVLARVHSECLTGDALFSLRCD 66
           +PT +GDF +  +  +   A G D V     D       VL RVHSE   G+ +  L+ +
Sbjct: 197 MPTDYGDFRLHVYNVIYDPARGIDLVLTCGKDKFDEDETVLVRVHSEWSIGNIVNRLKNE 256

Query: 67  CGFQLEAALTQIAEEGRGILLYHR---QEGRNIGLLNKIRAYALQDQGYDTVEANHQLGF 123
            G  L  A+ Q+A+EG GI+++ R   ++  N GL +  +      +  D    N ++  
Sbjct: 257 EGSSLNRAMKQVADEGSGIIVFLRNTPEQAANSGLFSDSK------RPTDIWMENGEIKT 310

Query: 124 --AADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERV 169
               D   + L A + + LGV ++RL++N+P     +   G+ IVE+V
Sbjct: 311 LRPKDGMAYGLGAQILRDLGVRKMRLMSNSPSSFIGINNYGLEIVEQV 358


>UniRef50_A0M3F6 Riboflavin biosynthesis protein n=17 Tax=Bacteroidetes
           RepID=A0M3F6_GRAFK
          Length = 382

 Score = 57.8 bits (138), Expect = 2e-07,   Method: Compositional matrix adjust.
 Identities = 41/168 (24%), Positives = 80/168 (47%), Gaps = 5/168 (2%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           +K+  + +L T +G F +  +E+      HVAL  G       ++ RV+S  +  D L +
Sbjct: 217 IKKKEDFELDTRFGKFRLRAYEQTTNSQVHVALTKGAWKPSEEIMVRVNSTLVNNDILGT 276

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
           L  +   +L+     I +EGRG +++     ++  LLN++     + Q    ++A     
Sbjct: 277 LTNNADKKLDGMFKAINDEGRGAIVFINPANQSPNLLNRLTELK-ESQKNGEIKAPP--- 332

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEI-LTEAGINIVERV 169
              D +DF + A +   L ++++RLL+N  +   + +   G+ I E V
Sbjct: 333 VKMDNKDFGIGAQILHDLEIHKIRLLSNTQQSKRVGMIGYGLEITEYV 380


>UniRef50_Q1DG18 GTP cyclohydrolase-2 n=2 Tax=Bacteria RepID=Q1DG18_MYXXD
          Length = 454

 Score = 56.2 bits (134), Expect = 6e-07,   Method: Compositional matrix adjust.
 Identities = 40/138 (28%), Positives = 64/138 (46%), Gaps = 11/138 (7%)

Query: 45  PVLARVHSECLTGDALFSLRCDC----GFQLEAALTQIAEEGRGILLYHRQEGRNIGLLN 100
           P+  RVH EC   D   S  C C       +E  +      G G+++Y R+EGR +G + 
Sbjct: 274 PLTVRVHDECNGSDVFGSDICTCRPYLAHGIEECVRTAQAGGAGLIVYLRKEGRALGEVT 333

Query: 101 KIRAYAL--QDQGYDTVEANHQ----LGFAADERDFTLCADMFKLLGVNEV-RLLTNNPK 153
           K   Y    + +G D+     Q    +    D R   L  D+   LG+  + R ++ +  
Sbjct: 334 KFLVYNARKRQEGGDSAATYFQRTECVAGVQDMRFQELMPDVLHWLGITRIHRFVSMSDM 393

Query: 154 KVEILTEAGINIVERVPL 171
           K + +T +GI I+ERVP+
Sbjct: 394 KHDAITRSGIEILERVPI 411


>UniRef50_Q1GEQ5 GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate
           synthase n=12 Tax=Alphaproteobacteria RepID=Q1GEQ5_SILST
          Length = 374

 Score = 56.2 bits (134), Expect = 6e-07,   Method: Compositional matrix adjust.
 Identities = 52/158 (32%), Positives = 77/158 (48%), Gaps = 22/158 (13%)

Query: 16  GDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAAL 75
           GD+ M  F +     +HV L+ GDI+   PVL R H+     D L  L      +L  A+
Sbjct: 234 GDWEMRIFTDQTHDVEHVVLIKGDITTPEPVLTRTHALHEASD-LLGLGPKPAGELPRAM 292

Query: 76  TQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCAD 135
             IA+EGRGI+   RQ  RN         YA  ++G  T++   Q G         L A 
Sbjct: 293 ELIADEGRGIVCLFRQP-RNA-------LYASDEEGVRTIK---QTG---------LGAQ 332

Query: 136 MFKLLGVNEVRLLTNNPKKVEILTEA-GINIVERVPLI 172
           +   LGV E+ LLT++P+   +  +A G++IV   P++
Sbjct: 333 ILNKLGVEELILLTDSPQTKYVGLDAYGLSIVGTRPIL 370


>UniRef50_UPI0001C31D71 34-dihydroxy-2-butanone 4-phosphate synthase n=1 Tax=Conexibacter
           woesei DSM 14684 RepID=UPI0001C31D71
          Length = 344

 Score = 55.8 bits (133), Expect = 7e-07,   Method: Compositional matrix adjust.
 Identities = 38/93 (40%), Positives = 49/93 (52%), Gaps = 6/93 (6%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLAR-VHSECLTGDALF 61
           ++RV E  LP P G F  +G+E  A   DHVAL  GD +   P   R VH  C  G+AL 
Sbjct: 216 VRRVVETALPLPAGPFRAIGYESAAGAADHVALALGDPA--APGAPRFVHLRC-GGEALG 272

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGR 94
              C C  +L++AL +IA  G G+L     E R
Sbjct: 273 --LCGCRARLDSALAEIAAAGDGVLAVLAGEDR 303


>UniRef50_D1ZD95 GTP cyclohydrolase-2 n=1 Tax=Sordaria macrospora RepID=D1ZD95_SORMA
          Length = 528

 Score = 55.8 bits (133), Expect = 8e-07,   Method: Compositional matrix adjust.
 Identities = 41/150 (27%), Positives = 64/150 (42%), Gaps = 27/150 (18%)

Query: 49  RVHSECLTGDALFSLRCDCG----FQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRA 104
           R+H EC   D   S  C C     F +E A+ +  + G G+++Y R+EGR +G + K R 
Sbjct: 333 RIHDECNGSDVFCSDICTCRPYLIFGIEEAVKEAQKGGSGVVIYFRKEGRALGEVTKYRM 392

Query: 105 YALQ----------------------DQGYDTVEANHQLGFAADERDFTLCADMFKLLGV 142
             LQ                      D   D  +    +    D R   L  D+   LG+
Sbjct: 393 SNLQTMLTFSCVEEFLIVYNARKRGADLASDYFKRTENIAGVKDMRFQALMPDILHWLGI 452

Query: 143 NEV-RLLTNNPKKVEILTEAGINIVERVPL 171
            ++ R+L+ +  K + +   GI I+ERV L
Sbjct: 453 TKIDRMLSMSNMKHDAIVGQGIPIIERVEL 482


>UniRef50_B7FNY5 Predicted protein n=1 Tax=Phaeodactylum tricornutum CCAP 1055/1
           RepID=B7FNY5_PHATR
          Length = 494

 Score = 55.1 bits (131), Expect = 1e-06,   Method: Compositional matrix adjust.
 Identities = 39/132 (29%), Positives = 60/132 (45%), Gaps = 11/132 (8%)

Query: 49  RVHSECLTGDALFSLRCDC----GFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRA 104
           RVH EC   D   S  C C       +E  +    + G GI++Y+R+EGR++G + K   
Sbjct: 310 RVHDECNGSDVFGSDICTCRPYLTHAIEECIRTAQKGGCGIVIYYRKEGRSLGEVTKYLV 369

Query: 105 YAL--QDQGYDTVE----ANHQLGFAADERDFTLCADMFKLLGVNEV-RLLTNNPKKVEI 157
           Y    + +G D+ E       Q+    D R   L  D    LGV ++   ++ +  K + 
Sbjct: 370 YNTRKRQEGGDSAERYFSCTEQVAGVQDTRFQALMPDPLHFLGVTKIDNFISMSDMKYDA 429

Query: 158 LTEAGINIVERV 169
           +   GI IV RV
Sbjct: 430 IVSTGIKIVNRV 441


>UniRef50_Q882G0 3,4-dihydroxy-2-butanone 4-phosphate synthase n=38
           Tax=Proteobacteria RepID=RIBB_PSESM
          Length = 369

 Score = 53.1 bits (126), Expect = 5e-06,   Method: Compositional matrix adjust.
 Identities = 46/172 (26%), Positives = 78/172 (45%), Gaps = 13/172 (7%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           + R+ E +LPT  G F +  +E+   G  H+A+V GDI    P L RVH      D + +
Sbjct: 206 IVRIGERELPTVHGTFRLFSYEDRIEGGVHMAMVMGDIRREDPTLVRVHVVDPLRDLVGA 265

Query: 63  -LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEAN--H 119
                  + L AAL ++AEEG G+++       +  LL +I       + Y   ++    
Sbjct: 266 EYTGPANWTLWAALQRVAEEGCGVVVVLANHESSQALLERIPQLTQPPRQYTRSQSRIYS 325

Query: 120 QLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPL 171
           ++G           A + + LG+ ++R L   P K   LT   + ++E +P 
Sbjct: 326 EVGTG---------AQILQDLGIGKLRHL-GPPLKYAGLTGYDLEVIESIPF 367


>UniRef50_A4A6E4 Riboflavin biosynthesis protein ribA n=5 Tax=unclassified
           Gammaproteobacteria RepID=A4A6E4_9GAMM
          Length = 380

 Score = 53.1 bits (126), Expect = 5e-06,   Method: Compositional matrix adjust.
 Identities = 43/173 (24%), Positives = 85/173 (49%), Gaps = 11/173 (6%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           ++RV E  + T +G+F +  + +   G  H+AL  G+IS   P L RVH+     D L S
Sbjct: 212 IERVREGVISTRYGNFQLATYRDRTHGGLHIALSLGEISATEPTLVRVHATSTLRDLLGS 271

Query: 63  -LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
            ++   G+ ++ +L  IA+ G G+L+   +   +  LL+ +      D     +E     
Sbjct: 272 DVQGQVGWSVQRSLAAIAKSGSGVLVLLGRSETDEQLLHSV------DLALGEIEPRDP- 324

Query: 122 GFAADERDFT-LCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIV 173
             A+D  +   + + + + LGV ++RL+   P K   ++  G+ +++ +  +V
Sbjct: 325 -KASDSYNTVGVGSQILRELGVGKIRLM-GAPIKYNAISGFGLEVIDYLEPVV 375


>UniRef50_Q2NZ90 3,4-dihydroxy-2-butanone 4-phosphate synthase n=11
           Tax=Gammaproteobacteria RepID=Q2NZ90_XANOM
          Length = 379

 Score = 53.1 bits (126), Expect = 5e-06,   Method: Compositional matrix adjust.
 Identities = 46/165 (27%), Positives = 72/165 (43%), Gaps = 10/165 (6%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           ++RV E  + T +G F +V + +      H ALV G    HTP L RV  E    D L  
Sbjct: 206 VERVDERDITTEFGPFKLVTYRDRIAHDLHFALVRGSADPHTPTLVRVQVENPLADLLHW 265

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
            R D G     AL  IA EG+G+++       +  LL ++R            EA     
Sbjct: 266 QRDDFGVAATDALRAIAAEGQGVMVVLSAPRDSESLLARLRQQP---------EAAANAK 316

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVE 167
             +  R     A +   LG+ ++R+L  + ++V +    G+ +VE
Sbjct: 317 DVSQWRRHGAGAQILAELGLGKLRVLGTSRRQVGV-AGFGLEVVE 360


>UniRef50_Q9US41 Uracil-regulated protein 1 n=101 Tax=cellular organisms
           RepID=URG1_SCHPO
          Length = 439

 Score = 52.8 bits (125), Expect = 7e-06,   Method: Compositional matrix adjust.
 Identities = 37/130 (28%), Positives = 60/130 (46%), Gaps = 9/130 (6%)

Query: 49  RVHSECLTGDALFSLRCDC----GFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRA 104
           RVH EC   D   S  C C     F +E A  +    G G+++Y R+EGR +G + K   
Sbjct: 268 RVHDECNGSDVFQSDICTCRPYLTFGIEEAAKEAQNGGAGLVVYFRKEGRALGEVVKYLV 327

Query: 105 YALQDQGYDTVE----ANHQLGFAADERDFTLCADMFKLLGVNEV-RLLTNNPKKVEILT 159
           Y  + +  D+ E       +L    D R   L  D+    G+ ++ R+L+ +  K + + 
Sbjct: 328 YNKRKRTGDSAENYFKRTEELAGVRDMRFQALMPDILHWFGIKKIDRMLSMSNMKHDAIV 387

Query: 160 EAGINIVERV 169
             GI I+ R+
Sbjct: 388 GQGIKILNRI 397


>UniRef50_D2UG04 Putative gtp cyclohydrolase II 3, 4-dihydroxy-2-butanone
           4-phosphate synthase, riboflavin biosynthesis protein
           n=1 Tax=Xanthomonas albilineans RepID=D2UG04_XANAL
          Length = 385

 Score = 52.4 bits (124), Expect = 1e-05,   Method: Compositional matrix adjust.
 Identities = 35/111 (31%), Positives = 50/111 (45%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           ++R+ E  + T +GDF +V + +      H ALV G +   TP L RV  E    D L  
Sbjct: 214 VERIDERPIVTEFGDFTLVTYRDRIAHDLHFALVRGPLDADTPTLVRVQVENPLADLLHW 273

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYD 113
            R D G     AL  IA   RG+++       +  LL ++RA      G D
Sbjct: 274 RREDFGVAASDALRAIATADRGVMVVLSAPRDSQALLARLRAQPEAAHGKD 324


>UniRef50_B4RM34 3,4-dihydroxy-2-butanone 4-phosphate synthase n=47
           Tax=Proteobacteria RepID=B4RM34_NEIG2
          Length = 445

 Score = 52.0 bits (123), Expect = 1e-05,   Method: Compositional matrix adjust.
 Identities = 46/166 (27%), Positives = 73/166 (43%), Gaps = 18/166 (10%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           L+ + +A + TPWG+F    + +  +G  H+ALV G  S  T  L RVH      D    
Sbjct: 289 LEDMGDAPVQTPWGEFQQHVYVDKLSGETHLALVKGTPSADTETLVRVHEPFSVMD-FIQ 347

Query: 63  LRCDCGFQLEAAL--TQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQ 120
                 + L  AL   Q AE G  ILL+H ++G +  LL++            T+     
Sbjct: 348 ANPRHSWSLPKALERVQQAESGVVILLHHTEDGAS--LLDR------------TLPKGAN 393

Query: 121 LGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIV 166
             +  D + + + A +   L V ++R+L   P     LT  G+ +V
Sbjct: 394 QAYKWDSKSYGIGAQILAGLHVKKLRVL-GQPSSFTGLTGFGLEVV 438


>UniRef50_C0XBJ0 GTP cyclohydrolase-2 n=3 Tax=Lactobacillus gasseri
           RepID=C0XBJ0_9LACO
          Length = 96

 Score = 52.0 bits (123), Expect = 1e-05,   Method: Compositional matrix adjust.
 Identities = 26/61 (42%), Positives = 38/61 (62%)

Query: 134 ADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAEKMGHL 193
           A + K L + E+ LLTNNP K++ L + GI I +R+PL +  N  +  YL TK ++  HL
Sbjct: 30  AVIVKELKIKEINLLTNNPDKIDQLNDYGIKINKRIPLEIAPNDVDRFYLQTKKKRFHHL 89

Query: 194 L 194
           L
Sbjct: 90  L 90


>UniRef50_B2AIS6 RIBOFLAVIN BIOSYNTHESIS BIFUNCTIONAL PROTEIN : GTP CYCLOHYDROLASE
           II AND 3, 4-DIHYDROXY-2-BUTANONE-4-PHOSPHATE SYNTHASE
           (DHBP SYNTHASE) n=3 Tax=Cupriavidus RepID=B2AIS6_CUPTR
          Length = 366

 Score = 49.7 bits (117), Expect = 5e-05,   Method: Compositional matrix adjust.
 Identities = 30/86 (34%), Positives = 45/86 (52%), Gaps = 1/86 (1%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDAL-F 61
           L+R   ++L TP+G F +  + +      H+ALV G    HTPVL RV +  +  D L F
Sbjct: 208 LRRTRSSELATPFGRFTVHAYHDAPVDALHLALVLGRPDPHTPVLTRVQAVEMQRDVLAF 267

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILL 87
                  + LE +L +I  EG G+L+
Sbjct: 268 GTPAQPAWNLERSLERIGAEGCGVLV 293


>UniRef50_UPI0001BCED67 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP
           cyclohydrolase II protein n=1 Tax=Campylobacter fetus
           subsp. venerealis str. Azul-94 RepID=UPI0001BCED67
          Length = 169

 Score = 49.3 bits (116), Expect = 6e-05,   Method: Compositional matrix adjust.
 Identities = 30/90 (33%), Positives = 44/90 (48%), Gaps = 1/90 (1%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           ++R  E   PT +G+F  + + E+ T  +HVALV GDIS     L RV +  + GD   +
Sbjct: 69  IEREIEKPFPTNYGEFRAIIYREVLTEQEHVALVKGDISSGA-ALVRVQAGNVFGDIFNA 127

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQE 92
              D    +  A+ QI    +   LY R E
Sbjct: 128 SGLDGAKIIAGAMQQIERAEKEFFLYMRHE 157


>UniRef50_A7IMW5 3,4-dihydroxy-2-butanone 4-phosphate synthase n=93
           Tax=Alphaproteobacteria RepID=A7IMW5_XANP2
          Length = 437

 Score = 49.3 bits (116), Expect = 7e-05,   Method: Compositional matrix adjust.
 Identities = 47/169 (27%), Positives = 75/169 (44%), Gaps = 14/169 (8%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           + R AE  +PT  G+     +       +H+ALV G I     VL R+H      DA   
Sbjct: 281 VTRAAEFPVPTCVGELQGFSYVTPFDPVNHLALVKGRIGDGEKVLVRLHRADPIADAFGG 340

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
                G  ++ AL +I  EGRG+L+Y R           + A A+   G+   +++ ++ 
Sbjct: 341 -----GKTIQRALERIEAEGRGVLVYLRDG------TAGVPAVAM---GHGGEKSSSEIE 386

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPL 171
                R+  L A + + LG+  +RLL +  +    L   GI IV+  PL
Sbjct: 387 RDRHWREVGLGAQILRDLGIVSIRLLASKSRTYVGLAGFGIEIVDTEPL 435


>UniRef50_A8PF74 GTP cyclohydrolase-2 n=1 Tax=Coprinopsis cinerea okayama7#130
           RepID=A8PF74_COPC7
          Length = 513

 Score = 48.1 bits (113), Expect = 2e-04,   Method: Compositional matrix adjust.
 Identities = 32/124 (25%), Positives = 59/124 (47%), Gaps = 9/124 (7%)

Query: 54  CLTGDALFSLRCDCG----FQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQD 109
           C   D   S  C C     + +E  +    + G G++ Y R+EGR +G + K   Y L+ 
Sbjct: 341 CNGSDVFGSDICTCKPYLVYAIEECIRGAQKGGVGVVAYFRKEGRALGEVTKYLVYNLRK 400

Query: 110 QGYDTVE----ANHQLGFAADERDFTLCADMFKLLGVNEV-RLLTNNPKKVEILTEAGIN 164
           +G D+ +    +   +    D R   L  D+   LG+ +V R+++ +  K + + ++GI 
Sbjct: 401 RGGDSADKYFKSTEMIAGVKDMRFQALMPDVLHWLGIRKVDRMVSMSDMKYDAIVKSGIP 460

Query: 165 IVER 168
           I+ R
Sbjct: 461 ILTR 464


>UniRef50_D0LW49 3,4-dihydroxy-2-butanone 4-phosphate synthase n=2 Tax=cellular
           organisms RepID=D0LW49_HALO1
          Length = 408

 Score = 47.4 bits (111), Expect = 2e-04,   Method: Compositional matrix adjust.
 Identities = 41/126 (32%), Positives = 66/126 (52%), Gaps = 11/126 (8%)

Query: 47  LARVHSECLTGDALFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYA 106
           L RV S    GD  F ++     +L AAL  I + G G+ LY   + R+  L +  R +A
Sbjct: 260 LVRVQSVSPVGDT-FGVKP----ELAAALRTIDDAGVGVCLYVYNKARS-SLEHDFRKHA 313

Query: 107 LQDQGYDTVEANHQLGFAADE-RDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINI 165
           L++     +E     G  ++  RDF L A +   LG ++VRLL+N+ +++  +   GI +
Sbjct: 314 LRE----AIEPPAGGGAHSETLRDFGLGAQVLADLGCHKVRLLSNSSRRIAGIEGFGIEV 369

Query: 166 VERVPL 171
           VERV +
Sbjct: 370 VERVAI 375


>UniRef50_Q5K843 GTP cyclohydrolase-2 n=5 Tax=Eukaryota RepID=Q5K843_CRYNE
          Length = 562

 Score = 47.4 bits (111), Expect = 3e-04,   Method: Compositional matrix adjust.
 Identities = 34/134 (25%), Positives = 58/134 (43%), Gaps = 9/134 (6%)

Query: 44  TPVLARVHSECLTGDALFSLRCDCG----FQLEAALTQIAEEGRGILLYHRQEGRNIGLL 99
           T V  R H  C   D   S  C C     F +  A+      G G+++Y ++EGR +G +
Sbjct: 381 TEVTCRPHDSCSGSDVFGSDICTCRPYLIFGISEAIKCAQRGGVGVIVYFQKEGRALGEV 440

Query: 100 NKIRAYALQDQGYDTVEA----NHQLGFAADERDFTLCADMFKLLGVNEV-RLLTNNPKK 154
            K   Y  + +G DT         ++    D R   L  D+   LG+  +  L++ +  K
Sbjct: 441 VKYMVYNRRKRGGDTAAEYFNNTERVAGVKDARHQALMPDVLHFLGIKHIHNLISMSNMK 500

Query: 155 VEILTEAGINIVER 168
            + +  +GI + +R
Sbjct: 501 YDAIIGSGITVGKR 514


>UniRef50_A4JQ12 GTP cyclohydrolase II n=9 Tax=Proteobacteria RepID=A4JQ12_BURVG
          Length = 382

 Score = 46.6 bits (109), Expect = 5e-04,   Method: Compositional matrix adjust.
 Identities = 40/143 (27%), Positives = 66/143 (46%), Gaps = 26/143 (18%)

Query: 31  DHVALVYGDISGHTPVLARVHS-----ECLTGDALFSLRCDCGFQLEAALTQIAEEGRGI 85
           +H+A V GD+ G  PVL R+H+     + + G  L SLR         A   +  E RG+
Sbjct: 249 EHIAFVMGDLRGADPVLVRMHAMDTMNDVIGGHHLASLR--------GAARLLENENRGV 300

Query: 86  LLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNEV 145
           ++  R E R   +  ++RA              H      + RD+ + A +   LGV  +
Sbjct: 301 IVVIR-ESRLTAVSERVRAMM------------HPKPAEPELRDYGIGAQILTELGVKNM 347

Query: 146 RLLTNNPKKVEILTEAGINIVER 168
            LL+N+ + +  L   G+N+VE+
Sbjct: 348 ILLSNHERTIVGLEGYGLNMVEQ 370


>UniRef50_C1HDW1 GTP cyclohydrolase-2 n=2 Tax=Onygenales RepID=C1HDW1_PARBA
          Length = 500

 Score = 44.7 bits (104), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 33/128 (25%), Positives = 53/128 (41%), Gaps = 42/128 (32%)

Query: 49  RVHSECLTGDALFSLRCDCG----FQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRA 104
           RVH EC   D   S  C C     F +E A+ +    G G+++Y R+EGR +G       
Sbjct: 363 RVHDECNGSDVFGSDICTCRPYLIFGIEEAVKEAQRGGSGVVIYFRKEGRALG------- 415

Query: 105 YALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNEV-RLLTNNPKKVEILTEAGI 163
                                         ++   LG+ ++ R+L+ +  K + + E GI
Sbjct: 416 ------------------------------EILHWLGITKIDRMLSMSNMKHDAIVEQGI 445

Query: 164 NIVERVPL 171
            I+ERVP+
Sbjct: 446 PILERVPI 453


>UniRef50_A6RZS8 GTP cyclohydrolase-2 n=1 Tax=Botryotinia fuckeliana B05.10
           RepID=A6RZS8_BOTFB
          Length = 470

 Score = 44.7 bits (104), Expect = 0.002,   Method: Compositional matrix adjust.
 Identities = 36/131 (27%), Positives = 57/131 (43%), Gaps = 18/131 (13%)

Query: 49  RVHSECLTGDALFSLRCDCG----FQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRA 104
           RVH EC   D   S  C C     + +E A+ +  + G G++ Y R+EGR +G + K   
Sbjct: 283 RVHDECNGSDVFGSDICTCRPYLIYGIEEAVKEAQKGGSGVI-YFRKEGRALGEVTKYLV 341

Query: 105 YALQDQGYDTV----EANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTE 160
           Y  + +G D      +    +    D R   L  D+   LG+ ++           +L+ 
Sbjct: 342 YNARKRGLDRASEYFKRTENIAGVKDMRFQALMPDILHWLGIKKID---------RMLSM 392

Query: 161 AGINIVERVPL 171
           + I I ERV L
Sbjct: 393 SKIPIHERVEL 403


>UniRef50_Q0E2P5 Os02g0223200 protein (Fragment) n=2 Tax=Oryza sativa Japonica Group
           RepID=Q0E2P5_ORYSJ
          Length = 157

 Score = 43.1 bits (100), Expect = 0.005,   Method: Compositional matrix adjust.
 Identities = 20/45 (44%), Positives = 29/45 (64%)

Query: 103 RAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNEVRL 147
           R Y L D G+DTV+AN +LG A D R++ + A + K +G+   RL
Sbjct: 69  RTYNLLDDGHDTVQANVELGLAVDSREYGIGAQVAKFVGLKGYRL 113


>UniRef50_UPI0001850D2C bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP
           cyclohydrolase II protein n=1 Tax=Bacillus coahuilensis
           m4-4 RepID=UPI0001850D2C
          Length = 187

 Score = 42.7 bits (99), Expect = 0.006,   Method: Compositional matrix adjust.
 Identities = 34/156 (21%), Positives = 72/156 (46%), Gaps = 32/156 (20%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSEC----LTGD 58
           +++ +E +L      F ++ ++++ TG +H+AL+ G  S  T    RVH+E     LTGD
Sbjct: 57  IEKTSEQRLVIQGDTFELITYQDIFTGLEHLALIKGKPSDET-TYVRVHAESLIKELTGD 115

Query: 59  ALFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEAN 118
           +           ++  + Q+  +  G+ LY R                + +Q      + 
Sbjct: 116 S----------SVKQGIEQMKNKEHGVFLYIRS------------TKTIHEQI-----SE 148

Query: 119 HQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKK 154
            +LG     +D+ + A + + +G+ ++  +T++PKK
Sbjct: 149 EELGEDESLKDYGIGAQILQDIGIKKMIWITDHPKK 184


Searching..................................................done


Results from round 2


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value
Sequences used in model and found again:

UniRef50_C5D3N0 GTP cyclohydrolase-2 n=25 Tax=cellular organisms...   322   5e-87
UniRef50_A6T7Y5 GTP cyclohydrolase-2 n=139 Tax=cellular organism...   314   8e-85
UniRef50_P74104 GTP cyclohydrolase-2 n=580 Tax=cellular organism...   308   7e-83
UniRef50_C9M9Y1 3,4-dihydroxy-2-butanone 4-phosphate synthase/GT...   306   2e-82
UniRef50_Q11WK6 GTP cyclohydrolase-2 n=44 Tax=Bacteria RepID=RIB...   302   4e-81
UniRef50_D1IKX7 Whole genome shotgun sequence of line PN40024, s...   301   1e-80
UniRef50_Q2SA07 GTP cyclohydrolase-2 n=16 Tax=Bacteria RepID=RIB...   300   1e-80
UniRef50_A4VHT9 GTP cyclohydrolase-2 n=5 Tax=Proteobacteria RepI...   299   3e-80
UniRef50_B9HF78 Predicted protein (Fragment) n=10 Tax=cellular o...   297   9e-80
UniRef50_Q65SC0 GTP cyclohydrolase-2 n=55 Tax=Bacteria RepID=RIB...   296   3e-79
UniRef50_O84736 GTP cyclohydrolase-2 n=38 Tax=Bacteria RepID=RIB...   295   7e-79
UniRef50_Q4QNX8 GTP cyclohydrolase-2 n=78 Tax=cellular organisms...   294   8e-79
UniRef50_C4Z7I1 GTP cyclohydrolase II / 3,4-dihydroxy 2-butanone...   294   9e-79
UniRef50_P47924 GTP cyclohydrolase-2 n=36 Tax=cellular organisms...   294   1e-78
UniRef50_C4GH90 GTP cyclohydrolase-2 n=1 Tax=Kingella oralis ATC...   293   3e-78
UniRef50_A1T8K1 GTP cyclohydrolase-2 n=43 Tax=cellular organisms...   292   5e-78
UniRef50_A0PPL6 GTP cyclohydrolase-2 n=82 Tax=Bacteria RepID=RIB...   291   1e-77
UniRef50_P57863 GTP cyclohydrolase-2 n=17 Tax=Proteobacteria Rep...   290   2e-77
UniRef50_Q5F7N6 GTP cyclohydrolase-2 n=33 Tax=Bacteria RepID=RIB...   290   2e-77
UniRef50_C0VNE9 GTP cyclohydrolase-2 n=2 Tax=Moraxellaceae RepID...   289   3e-77
UniRef50_C9KJZ5 3,4-dihydroxy-2-butanone 4-phosphate synthase/GT...   284   9e-76
UniRef50_C5CJ14 GTP cyclohydrolase II n=1 Tax=Kosmotoga olearia ...   281   1e-74
UniRef50_Q13NP8 GTP cyclohydrolase-2 n=9 Tax=cellular organisms ...   280   1e-74
UniRef50_D2RDK3 GTP cyclohydrolase II n=2 Tax=Archaeoglobaceae R...   278   5e-74
UniRef50_C8WEC3 GTP cyclohydrolase-2 n=10 Tax=Sphingomonadales R...   278   5e-74
UniRef50_UPI0001905AE1 GTP cyclohydrolase II protein n=1 Tax=Rhi...   276   3e-73
UniRef50_D2R1R5 GTP cyclohydrolase II n=3 Tax=Planctomycetaceae ...   273   2e-72
UniRef50_Q1D4N5 GTP cyclohydrolase-2 n=6 Tax=Cystobacterineae Re...   272   4e-72
UniRef50_O29766 GTP cyclohydrolase-2 n=1 Tax=Archaeoglobus fulgi...   272   4e-72
UniRef50_B8JBX2 GTP cyclohydrolase-2 n=5 Tax=Bacteria RepID=B8JB...   272   7e-72
UniRef50_D1BH22 GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4...   270   2e-71
UniRef50_D0LLG6 GTP cyclohydrolase-2 n=1 Tax=Haliangium ochraceu...   270   3e-71
UniRef50_Q9X2E6 GTP cyclohydrolase-2 n=13 Tax=cellular organisms...   267   1e-70
UniRef50_B0RC63 Riboflavin biosynthesis protein RibA n=7 Tax=Act...   267   1e-70
UniRef50_Q1GKN3 GTP cyclohydrolase-2 n=44 Tax=Rhodobacterales Re...   266   3e-70
UniRef50_Q6GFT5 GTP cyclohydrolase-2 n=76 Tax=Bacteria RepID=RIB...   266   3e-70
UniRef50_Q4L7B1 GTP cyclohydrolase-2 n=3 Tax=Staphylococcus RepI...   265   4e-70
UniRef50_Q4FV65 GTP cyclohydrolase-2 n=3 Tax=Psychrobacter RepID...   264   1e-69
UniRef50_P43525 GTP cyclohydrolase-2 n=6 Tax=Alphaproteobacteria...   263   2e-69
UniRef50_A8IZV5 Bifunctional GTP cyclohydrolase II n=1 Tax=Chlam...   263   2e-69
UniRef50_C0YM11 GTP cyclohydrolase-2 n=2 Tax=Chryseobacterium gl...   260   2e-68
UniRef50_A6C5C2 Riboflavin biosynthesis protein RibA n=1 Tax=Pla...   260   2e-68
UniRef50_Q1IPQ1 GTP cyclohydrolase-2 n=4 Tax=Bacteria RepID=Q1IP...   260   3e-68
UniRef50_UPI000050F87F bifunctional 3,4-dihydroxy-2-butanone 4-p...   258   5e-68
UniRef50_A9FWS8 GTP cyclohydrolase-2 n=1 Tax=Sorangium cellulosu...   257   1e-67
UniRef50_C7JCF3 Bifunctional protein 3,4-dihydroxy-2-butanone 4-...   256   3e-67
UniRef50_C9MTM9 GTP cyclohydrolase-2 n=1 Tax=Prevotella verorali...   255   4e-67
UniRef50_A7I3X0 GTP cyclohydrolase-2 n=6 Tax=cellular organisms ...   255   5e-67
UniRef50_B9L8K1 GTP cyclohydrolase-2 n=3 Tax=Bacteria RepID=B9L8...   255   5e-67
UniRef50_A0RR75 GTP cyclohydrolase-2 n=10 Tax=Epsilonproteobacte...   255   6e-67
UniRef50_C1E155 Predicted protein n=2 Tax=Micromonas RepID=C1E15...   255   7e-67
UniRef50_A4XHM6 GTP cyclohydrolase II n=2 Tax=Clostridia RepID=A...   254   1e-66
UniRef50_A0JVK1 GTP cyclohydrolase-2 n=2 Tax=Micrococcaceae RepI...   254   1e-66
UniRef50_D0NCB5 Riboflavin biosynthesis protein ribBA, putative ...   253   2e-66
UniRef50_A5G2C3 GTP cyclohydrolase-2 n=2 Tax=Rhodospirillales Re...   253   3e-66
UniRef50_A4RYG5 Predicted protein n=1 Tax=Ostreococcus lucimarin...   253   3e-66
UniRef50_C6V5M6 GTP cyclohydrolase-2 n=2 Tax=Neorickettsia RepID...   253   3e-66
UniRef50_B7IF97 A 3,4-dihydroxy-2-butanone 4-phosphate synthase/...   252   5e-66
UniRef50_C7NTK7 GTP cyclohydrolase II n=1 Tax=Halorhabdus utahen...   252   7e-66
UniRef50_B8H6T8 GTP cyclohydrolase-2 n=1 Tax=Arthrobacter chloro...   251   8e-66
UniRef50_Q17XC9 GTP cyclohydrolase-2 n=13 Tax=Helicobacter RepID...   250   2e-65
UniRef50_C6X006 GTP cyclohydrolase-2 n=1 Tax=Flavobacteriaceae b...   247   2e-64
UniRef50_Q1QYD0 GTP cyclohydrolase-2 n=1 Tax=Chromohalobacter sa...   245   6e-64
UniRef50_A6G7P6 GTP cyclohydrolase-2 n=1 Tax=Plesiocystis pacifi...   245   8e-64
UniRef50_C4K9I6 GTP cyclohydrolase-2 n=1 Tax=Thauera sp. MZ1T Re...   244   1e-63
UniRef50_Q604R2 Riboflavin-specific deaminase/GTP cyclohydrolase...   244   2e-63
UniRef50_Q83FM7 GTP cyclohydrolase-2 n=2 Tax=Tropheryma whipplei...   243   2e-63
UniRef50_B9ZQZ7 GTP cyclohydrolase-2 n=1 Tax=Thioalkalivibrio sp...   243   2e-63
UniRef50_Q7VK48 GTP cyclohydrolase-2 n=2 Tax=Helicobacteraceae R...   241   9e-63
UniRef50_UPI000051036D riboflavin-specific deaminase/GTP cyclohy...   241   1e-62
UniRef50_A6VWW9 GTP cyclohydrolase-2 n=47 Tax=Bacteria RepID=RIB...   240   1e-62
UniRef50_A6W477 GTP cyclohydrolase-2 n=8 Tax=Bacteria RepID=A6W4...   239   3e-62
UniRef50_A6DFW0 GTP cyclohydrolase-2 n=1 Tax=Lentisphaera araneo...   239   5e-62
UniRef50_B2GGU5 GTP cyclohydrolase-2 n=1 Tax=Kocuria rhizophila ...   238   8e-62
UniRef50_A1SSA8 GTP cyclohydrolase-2 n=10 Tax=Gammaproteobacteri...   237   1e-61
UniRef50_D2NTM1 GTP cyclohydrolase II n=2 Tax=Rothia mucilaginos...   237   2e-61
UniRef50_D2LG53 GTP cyclohydrolase II n=1 Tax=Rhodomicrobium van...   236   3e-61
UniRef50_B3CNI0 GTP cyclohydrolase-2 n=13 Tax=Wolbachia RepID=B3...   236   3e-61
UniRef50_Q03XZ0 GTP cyclohydrolase II n=1 Tax=Leuconostoc mesent...   235   7e-61
UniRef50_C6QGG9 GTP cyclohydrolase-2 n=1 Tax=Hyphomicrobium deni...   232   8e-60
UniRef50_Q87D69 GTP cyclohydrolase-2 n=22 Tax=Proteobacteria Rep...   226   2e-58
UniRef50_C7R1D1 3,4-dihydroxy-2-butanone 4-phosphate synthase n=...   223   2e-57
UniRef50_A5ARE3 Putative uncharacterized protein n=1 Tax=Vitis v...   222   4e-57
UniRef50_A8FIW0 GTP cyclohydrolase-2 n=7 Tax=Bacillales RepID=A8...   221   7e-57
UniRef50_Q4V1U4 GTP cyclohydrolase-2 n=26 Tax=Bacillus cereus gr...   220   2e-56
UniRef50_Q3YT81 GTP cyclohydrolase-2 n=6 Tax=canis group RepID=Q...   220   2e-56
UniRef50_P51618 GTP cyclohydrolase-2 n=63 Tax=Gammaproteobacteri...   220   2e-56
UniRef50_C5AMM6 GTP cyclohydrolase-2 n=2 Tax=Burkholderia glumae...   219   3e-56
UniRef50_B9KHB1 GTP cyclohydrolase-2 n=5 Tax=Anaplasma RepID=B9K...   218   6e-56
UniRef50_C9S9H3 GTP cyclohydrolase-2 n=1 Tax=Verticillium albo-a...   216   3e-55
UniRef50_A8NX34 GTP cyclohydrolase-2 n=2 Tax=Agaricales RepID=A8...   215   5e-55
UniRef50_B0UFT4 GTP cyclohydrolase-2 n=4 Tax=Rhizobiales RepID=B...   214   1e-54
UniRef50_Q14FW6 Riboflavin biosynthesis protein ribA/GTP-cyclohy...   213   2e-54
UniRef50_P50139 GTP cyclohydrolase-2 n=33 Tax=Ascomycota RepID=R...   212   4e-54
UniRef50_P38066 GTP cyclohydrolase-2 n=8 Tax=Saccharomycetales R...   208   1e-52
UniRef50_B8KSW9 GTP cyclohydrolase-2 n=1 Tax=gamma proteobacteri...   207   1e-52
UniRef50_A6MYZ0 GTP cyclohydrolase-2 n=2 Tax=Saccharomycetaceae ...   205   9e-52
UniRef50_A0Z3E0 GTP cyclohydrolase-2 n=1 Tax=marine gamma proteo...   204   1e-51
UniRef50_C9PF77 GTP cyclohydrolase II n=1 Tax=Vibrio furnissii C...   203   4e-51
UniRef50_A8FAX3 GTP cyclohydrolase-2 n=2 Tax=Bacillus pumilus Re...   202   6e-51
UniRef50_C5LSF0 GTP cyclohydrolase II, putative (Fragment) n=1 T...   200   2e-50
UniRef50_C0A9J6 GTP cyclohydrolase-2 n=1 Tax=Opitutaceae bacteri...   200   2e-50
UniRef50_Q5KNS2 GTP cyclohydrolase-2 n=1 Tax=Filobasidiella neof...   200   3e-50
UniRef50_Q4P4Y7 GTP cyclohydrolase-2 n=2 Tax=Basidiomycota RepID...   198   1e-49
UniRef50_D0L7U8 3,4-dihydroxy-2-butanone 4-phosphate synthase n=...   197   1e-49
UniRef50_Q2S6L1 3,4-dihydroxy-2-butanone 4-phosphate synthase/GT...   195   8e-49
UniRef50_A1SF04 GTP cyclohydrolase-2 n=16 Tax=Bacteria RepID=A1S...   193   3e-48
UniRef50_A0SNY3 Riboflavin biosynthesis protein RibA n=2 Tax=Can...   183   4e-45
UniRef50_A8PZB1 GTP cyclohydrolase-2 n=1 Tax=Malassezia globosa ...   181   8e-45
UniRef50_Q0D0K3 GTP cyclohydrolase-2 n=29 Tax=Leotiomyceta RepID...   181   1e-44
UniRef50_C5RMY3 GTP cyclohydrolase-2 n=1 Tax=Clostridium cellulo...   178   1e-43
UniRef50_Q5YVN1 GTP cyclohydrolase-2 n=1 Tax=Nocardia farcinica ...   177   2e-43
UniRef50_A2TRN2 GTP cyclohydrolase-2 n=1 Tax=Dokdonia donghaensi...   171   1e-41
UniRef50_Q6KH48 GTP cyclohydrolase-2 n=1 Tax=Mycoplasma mobile R...   171   1e-41
UniRef50_Q08VV8 GTP cyclohydrolase-2 n=1 Tax=Stigmatella auranti...   168   9e-41
UniRef50_A9QS81 GTP cyclohydrolase-2 n=1 Tax=Lactococcus lactis ...   163   4e-39
UniRef50_A0M3F6 Riboflavin biosynthesis protein n=17 Tax=Bactero...   149   4e-35
UniRef50_Q6MIV8 GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone...   148   1e-34
UniRef50_C0YN89 3,4-dihydroxy-2-butanone-4-phosphate synthase n=...   148   1e-34
UniRef50_B5JMM0 3,4-dihydroxy-2-butanone 4-phosphate synthase fa...   145   7e-34
UniRef50_C6X067 3,4-dihydroxy-2-butanone 4-phosphate synthase / ...   144   1e-33
UniRef50_A0SNY4 Riboflavin biosynthesis protein RibA n=2 Tax=Can...   144   2e-33
UniRef50_Q2NZ90 3,4-dihydroxy-2-butanone 4-phosphate synthase n=...   141   1e-32
UniRef50_A6DFW1 3,4-dihydroxy-2-butanone 4-phosphate synthase/GT...   140   3e-32
UniRef50_Q882G0 3,4-dihydroxy-2-butanone 4-phosphate synthase n=...   139   3e-32
UniRef50_C5FIC6 GTP cyclohydrolase-2 n=1 Tax=Microsporum canis C...   139   4e-32
UniRef50_A7IMW5 3,4-dihydroxy-2-butanone 4-phosphate synthase n=...   137   2e-31
UniRef50_Q9R6K1 GTP cyclohydrolase-2 n=1 Tax=Agrobacterium tumef...   133   2e-30
UniRef50_B4RM34 3,4-dihydroxy-2-butanone 4-phosphate synthase n=...   133   4e-30
UniRef50_D2UG04 Putative gtp cyclohydrolase II 3, 4-dihydroxy-2-...   133   4e-30
UniRef50_Q1DG18 GTP cyclohydrolase-2 n=2 Tax=Bacteria RepID=Q1DG...   132   6e-30
UniRef50_D0NXG3 Putative uncharacterized protein n=1 Tax=Phytoph...   132   6e-30
UniRef50_D1ZD95 GTP cyclohydrolase-2 n=1 Tax=Sordaria macrospora...   132   8e-30
UniRef50_B7FNY5 Predicted protein n=1 Tax=Phaeodactylum tricornu...   132   8e-30
UniRef50_Q5K843 GTP cyclohydrolase-2 n=5 Tax=Eukaryota RepID=Q5K...   130   3e-29
UniRef50_Q9US41 Uracil-regulated protein 1 n=101 Tax=cellular or...   129   5e-29
UniRef50_A4A6E4 Riboflavin biosynthesis protein ribA n=5 Tax=unc...   127   2e-28
UniRef50_Q1AZ21 GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone...   124   1e-27
UniRef50_A6RZS8 GTP cyclohydrolase-2 n=1 Tax=Botryotinia fuckeli...   120   3e-26
UniRef50_A8PF74 GTP cyclohydrolase-2 n=1 Tax=Coprinopsis cinerea...   118   8e-26
UniRef50_Q1GEQ5 GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone...   118   9e-26
UniRef50_A6G9U6 3,4-dihydroxy-2-butanone 4-phosphate synthase/GT...   116   6e-25
UniRef50_Q1AV39 GTP cyclohydrolase-2 n=1 Tax=Rubrobacter xylanop...   114   2e-24
UniRef50_A4JQ12 GTP cyclohydrolase II n=9 Tax=Proteobacteria Rep...   114   2e-24
UniRef50_A0PS46 Riboflavin biosynthesis protein RibA1 n=16 Tax=C...   111   1e-23
UniRef50_B2AIS6 RIBOFLAVIN BIOSYNTHESIS BIFUNCTIONAL PROTEIN : G...   110   3e-23
UniRef50_D0LW49 3,4-dihydroxy-2-butanone 4-phosphate synthase n=...   109   5e-23
UniRef50_C1HDW1 GTP cyclohydrolase-2 n=2 Tax=Onygenales RepID=C1...   104   2e-21
UniRef50_Q59AD7 GTP cyclohydrolase-2 (Fragment) n=2 Tax=Buchnera...   100   4e-20
UniRef50_UPI0001BCED67 bifunctional 3,4-dihydroxy-2-butanone 4-p...    96   4e-19
UniRef50_C0XBJ0 GTP cyclohydrolase-2 n=3 Tax=Lactobacillus gasse...    91   2e-17
UniRef50_UPI0001C31D71 34-dihydroxy-2-butanone 4-phosphate synth...    81   2e-14

Sequences not found previously or not previously below threshold:

UniRef50_Q2G801 GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone...   107   2e-22
UniRef50_Q1QUC7 GTP cyclohydrolase II n=69 Tax=cellular organism...   106   5e-22
UniRef50_Q0G5B3 GTP CYCLOHYDROLASE II / 3,4-DIHYDROXY-2-BUTANONE...    89   1e-16
UniRef50_UPI0001850D2C bifunctional 3,4-dihydroxy-2-butanone 4-p...    86   6e-16
UniRef50_Q1UZ97 GTP cyclohydrolase II /3,4-dihydroxy-2-butanone ...    73   6e-12
UniRef50_Q0E2P5 Os02g0223200 protein (Fragment) n=2 Tax=Oryza sa...    61   2e-08
UniRef50_Q9APK4 GTP cyclohydrolase-2 (Fragment) n=1 Tax=Hyphomic...    58   2e-07
UniRef50_Q9PHU4 3,4-dihydroxy-2-butanone 4-phosphate synthase n=...    55   1e-06
UniRef50_B7FLV1 Putative uncharacterized protein n=1 Tax=Medicag...    54   2e-06
UniRef50_A8HP30 Bifunctional GTP cyclohydrolase (Fragment) n=3 T...    54   3e-06
UniRef50_Q2GW54 Putative uncharacterized protein n=1 Tax=Chaetom...    54   3e-06
UniRef50_C7MUB0 3,4-dihydroxy-2-butanone 4-phosphate synthase n=...    54   4e-06
UniRef50_UPI0001B53FE8 hypothetical protein StAA4_17215 n=1 Tax=...    52   1e-05
UniRef50_Q9ZL40 3,4-dihydroxy-2-butanone 4-phosphate synthase n=...    52   1e-05
UniRef50_O68249 3,4-dihydroxy-2-butanone 4-phosphate synthase n=...    51   2e-05
UniRef50_D0NPB4 Riboflavin biosynthesis protein ribBA, putative ...    44   0.002
UniRef50_UPI0001699144 3,4-dihydroxy-2-butanone 4-phosphate synt...    40   0.037

>UniRef50_C5D3N0 GTP cyclohydrolase-2 n=25 Tax=cellular organisms RepID=RIBBA_GEOSW
          Length = 397

 Score =  322 bits (825), Expect = 5e-87,   Method: Composition-based stats.
 Identities = 114/193 (59%), Positives = 139/193 (72%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           +KR  E  LPT +G F  +G+  +  G +HVALV G+I    P L RVHSECLTGD   S
Sbjct: 204 VKREVEVMLPTEFGKFKAIGYTNIVDGKEHVALVKGEIIPDEPTLVRVHSECLTGDVFGS 263

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
            RCDCG QL AAL QI EEGRG+LLY RQEGR IGL+NK+RAY LQ+QGYDTVEAN +LG
Sbjct: 264 CRCDCGPQLHAALRQIEEEGRGVLLYMRQEGRGIGLINKLRAYKLQEQGYDTVEANERLG 323

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHY 182
           F AD RD+ + A + K LGV ++RLLTNNP+K+  L   G+ +VERVPL +  N  NE Y
Sbjct: 324 FPADLRDYGIGAQILKDLGVTKMRLLTNNPRKITGLKGHGLEVVERVPLQMPANKENEKY 383

Query: 183 LDTKAEKMGHLLN 195
           L TK EK+GH+L+
Sbjct: 384 LRTKYEKLGHMLH 396


>UniRef50_A6T7Y5 GTP cyclohydrolase-2 n=139 Tax=cellular organisms RepID=RIBA_KLEP7
          Length = 200

 Score =  314 bits (806), Expect = 8e-85,   Method: Composition-based stats.
 Identities = 184/196 (93%), Positives = 187/196 (95%)

Query: 1   MQLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDAL 60
           MQLKRVAEAKLPTPWGDFLMVGFEELATG DHVALVYGDISG +PVLARVHSECLTGDAL
Sbjct: 1   MQLKRVAEAKLPTPWGDFLMVGFEELATGQDHVALVYGDISGQSPVLARVHSECLTGDAL 60

Query: 61  FSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQ 120
           FSLRCDCGFQLEAAL+ IAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQ
Sbjct: 61  FSLRCDCGFQLEAALSHIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQ 120

Query: 121 LGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNE 180
           LGFAADERDFTLCADMFKLL V +VRLLTNNPKKVEILTEAGINIVERVPLIVGRNP N 
Sbjct: 121 LGFAADERDFTLCADMFKLLNVEQVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPKNA 180

Query: 181 HYLDTKAEKMGHLLNK 196
           HYLDTKA KMGHLLN 
Sbjct: 181 HYLDTKAAKMGHLLNS 196


>UniRef50_P74104 GTP cyclohydrolase-2 n=580 Tax=cellular organisms RepID=RIBBA_SYNY3
          Length = 556

 Score =  308 bits (789), Expect = 7e-83,   Method: Composition-based stats.
 Identities = 103/194 (53%), Positives = 137/194 (70%), Gaps = 2/194 (1%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDIS--GHTPVLARVHSECLTGDAL 60
           ++R    + P+ +G+F +  +  L    +H+A+V GD S  G  PV+ R+HSECLTGDAL
Sbjct: 207 VQRETICEFPSQFGEFKLYAYRNLLDQTEHIAIVKGDPSEFGQQPVMVRMHSECLTGDAL 266

Query: 61  FSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQ 120
            SLRCDC  QL+AAL  +   G G+++Y RQEGR IGL+NK++AY+LQD GYDTVEAN +
Sbjct: 267 GSLRCDCRMQLQAALKMLENHGLGVVVYLRQEGRGIGLVNKLKAYSLQDLGYDTVEANER 326

Query: 121 LGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNE 180
           LGF AD RD+ + A M   LGV ++RL+TNNP+K+  L   G+ IVERVPL++  N  N 
Sbjct: 327 LGFPADLRDYGMGAQMLNDLGVKQIRLITNNPRKIAGLKGYGLEIVERVPLLIEANDYNS 386

Query: 181 HYLDTKAEKMGHLL 194
           HYL TKAEK+GH L
Sbjct: 387 HYLTTKAEKLGHWL 400


>UniRef50_C9M9Y1 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
           n=1 Tax=Jonquetella anthropi E3_33 E1 RepID=C9M9Y1_9BACT
          Length = 416

 Score =  306 bits (785), Expect = 2e-82,   Method: Composition-based stats.
 Identities = 97/196 (49%), Positives = 130/196 (66%), Gaps = 3/196 (1%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFE---ELATGHDHVALVYGDISGHTPVLARVHSECLTGDA 59
           ++RVA   LP+ WGDF  + +    E      H+ALV GD+S     L RVHSEC+TGD 
Sbjct: 211 IERVASVHLPSAWGDFSAIAYRSQLETDPDRVHIALVKGDLSKEDAPLVRVHSECMTGDV 270

Query: 60  LFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANH 119
             SLRCDCG QL AA++ +   G G++LY RQEGR IGL+ K+RAY LQ++G DTV+AN 
Sbjct: 271 FGSLRCDCGPQLHAAMSMVERAGCGVVLYMRQEGRGIGLVEKLRAYELQEKGLDTVDANL 330

Query: 120 QLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNN 179
            LG   D RD+ + A + K LG+ ++RLLTNNP K+  L   G+ +VERVPL +  N  N
Sbjct: 331 ALGHKPDLRDYGVGAQILKDLGITKLRLLTNNPAKIVGLQGHGLEVVERVPLEIEPNRYN 390

Query: 180 EHYLDTKAEKMGHLLN 195
           + Y+ TK ++MGHLL+
Sbjct: 391 KKYMTTKEDRMGHLLH 406


>UniRef50_Q11WK6 GTP cyclohydrolase-2 n=44 Tax=Bacteria RepID=RIBBA_CYTH3
          Length = 405

 Score =  302 bits (775), Expect = 4e-81,   Method: Composition-based stats.
 Identities = 93/192 (48%), Positives = 128/192 (66%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           +KR     +PT  GDF ++ F +++TG  H+AL+ G      PV+ RVHS C+TGD   S
Sbjct: 210 VKREIGVDMPTNLGDFDLIAFRQISTGEVHLALIKGTWEKDEPVMVRVHSSCVTGDIFGS 269

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
            RCDCG QL  A+  I +EG+G++LY  QEGR IGLLNK++AY LQ+QG DTVEAN +LG
Sbjct: 270 CRCDCGPQLHKAMEMIQQEGKGVILYMNQEGRGIGLLNKLKAYKLQEQGRDTVEANLELG 329

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHY 182
           F  D+RD+   A + + L ++++RL+TNNP K   L   G+ I E VP+ +  NP+N  Y
Sbjct: 330 FKMDQRDYGTGAQILRDLNISKLRLITNNPVKRAALAGYGLEITEAVPIEIPSNPHNLEY 389

Query: 183 LDTKAEKMGHLL 194
           L TK +KMGH +
Sbjct: 390 LKTKRDKMGHTI 401


>UniRef50_D1IKX7 Whole genome shotgun sequence of line PN40024,
           scaffold_17.assembly12x (Fragment) n=19 Tax=cellular
           organisms RepID=D1IKX7_VITVI
          Length = 845

 Score =  301 bits (771), Expect = 1e-80,   Method: Composition-based stats.
 Identities = 90/192 (46%), Positives = 120/192 (62%), Gaps = 1/192 (0%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           + R A A++PT WG F    +  +  G +H+A+V G+I     +L RVHSECLTGD   S
Sbjct: 623 VDRSAGARIPTMWGPFTAYCYRSILDGIEHIAMVKGEIGDGQDILVRVHSECLTGDIFGS 682

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
            RCDCG QL  A+ QI + G+G+L+Y R  EGR IGL +K+ AY LQD G DTVEAN +L
Sbjct: 683 ARCDCGNQLALAMQQIEKAGKGVLVYLRGHEGRGIGLGHKLHAYNLQDDGRDTVEANEEL 742

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181
           G   D R++ + A M + LGV  ++L+TNNP K   L   G+ +  RVPL+      N  
Sbjct: 743 GLPVDSREYGIGAQMLRDLGVRTMKLMTNNPAKYIGLKGYGLAVSGRVPLLTPITKENGR 802

Query: 182 YLDTKAEKMGHL 193
           YL+TK  KMGH+
Sbjct: 803 YLETKRSKMGHV 814


>UniRef50_Q2SA07 GTP cyclohydrolase-2 n=16 Tax=Bacteria RepID=RIBA_HAHCH
          Length = 207

 Score =  300 bits (769), Expect = 1e-80,   Method: Composition-based stats.
 Identities = 129/195 (66%), Positives = 152/195 (77%)

Query: 1   MQLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDAL 60
           M +  VA  KLPTP+G F M GF+E+ T  +H+AL  GDI     VLAR HSECLTGDAL
Sbjct: 1   MSVTYVASCKLPTPFGVFDMHGFQEVGTQKEHIALTLGDIGDGASVLARTHSECLTGDAL 60

Query: 61  FSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQ 120
           FS+RCDCG+QL+ AL  IA EGRGILLY RQEGR IGLLNKIRAY LQDQG DTVEAN Q
Sbjct: 61  FSMRCDCGYQLDEALRSIAAEGRGILLYLRQEGRGIGLLNKIRAYNLQDQGADTVEANEQ 120

Query: 121 LGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNE 180
           LGFAAD RD+++C  M   LG++ +RL+TNNP+KV+ LT+ GI +VERVPL VGRNP+N 
Sbjct: 121 LGFAADMRDYSMCKPMLYHLGISRIRLMTNNPRKVDSLTKLGIEVVERVPLEVGRNPHNR 180

Query: 181 HYLDTKAEKMGHLLN 195
           +YL TKA K+GHLL 
Sbjct: 181 NYLATKAGKLGHLLT 195


>UniRef50_A4VHT9 GTP cyclohydrolase-2 n=5 Tax=Proteobacteria RepID=A4VHT9_PSEU5
          Length = 242

 Score =  299 bits (767), Expect = 3e-80,   Method: Composition-based stats.
 Identities = 120/196 (61%), Positives = 148/196 (75%)

Query: 1   MQLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDAL 60
           + +  VA ++LPTP+G F M GF +  TG +HVAL  GD++   PVL R+HSECLTGDAL
Sbjct: 38  VSVVFVAASQLPTPFGVFTMHGFLDQDTGKEHVALTLGDVADGKPVLGRLHSECLTGDAL 97

Query: 61  FSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQ 120
           FSLRCDCGFQLEAAL  IA+EGRG+LLY RQEGR IGLLNKIRAY LQD G DTVEAN +
Sbjct: 98  FSLRCDCGFQLEAALRAIADEGRGVLLYLRQEGRGIGLLNKIRAYELQDAGADTVEANER 157

Query: 121 LGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNE 180
           LGFA D RD+ +C  M + LG+ E++L+TNNP+KV+ L   GI + ER PL +  NP+N 
Sbjct: 158 LGFAPDMRDYGICLPMLEHLGIGEIKLMTNNPRKVKALQGFGIRVAERKPLQIAHNPHNR 217

Query: 181 HYLDTKAEKMGHLLNK 196
            YL TKA K+GH+L +
Sbjct: 218 KYLATKAGKLGHMLGE 233


>UniRef50_B9HF78 Predicted protein (Fragment) n=10 Tax=cellular organisms
           RepID=B9HF78_POPTR
          Length = 449

 Score =  297 bits (762), Expect = 9e-80,   Method: Composition-based stats.
 Identities = 92/192 (47%), Positives = 121/192 (63%), Gaps = 1/192 (0%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           ++  A A +PT WG F    +  L  G +H+A+V G+I     +L RVHSECLTGD   S
Sbjct: 248 VELAAAAPIPTMWGPFKAYCYRSLLDGIEHIAMVKGEIGDGKDILVRVHSECLTGDIFGS 307

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
            RCDCG QL  A+ QI   GRG+L+Y R  EGR IGL +K+RAY LQD G DTVEAN +L
Sbjct: 308 ARCDCGKQLALAMKQIEAAGRGVLVYLRGHEGRGIGLGHKLRAYNLQDDGRDTVEANEEL 367

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181
           G   D R++ + A + + LGV+ ++L+TNNP K   L   G+ +  RVPL+      N  
Sbjct: 368 GLPVDSREYGIGAQILRDLGVHTMKLMTNNPAKYVGLKGYGLAVAGRVPLLTPITMENRR 427

Query: 182 YLDTKAEKMGHL 193
           YL+TK EKMGH+
Sbjct: 428 YLETKREKMGHV 439


>UniRef50_Q65SC0 GTP cyclohydrolase-2 n=55 Tax=Bacteria RepID=RIBA_MANSM
          Length = 219

 Score =  296 bits (758), Expect = 3e-79,   Method: Composition-based stats.
 Identities = 129/195 (66%), Positives = 158/195 (81%), Gaps = 2/195 (1%)

Query: 2   QLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHT--PVLARVHSECLTGDA 59
           +++RVAEA LPT +G F +VGFE   T  +HVALV GDIS     PVLAR+HSECLTGDA
Sbjct: 3   KIQRVAEANLPTEFGLFRIVGFEFPDTKKEHVALVMGDISNSEENPVLARIHSECLTGDA 62

Query: 60  LFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANH 119
           L SL+CDCGFQL  AL QI+E GRG+L+YHR+EGR IGL+NKIRAY+LQD G DT+EAN 
Sbjct: 63  LHSLKCDCGFQLSTALRQISEAGRGVLIYHREEGRGIGLINKIRAYSLQDNGMDTIEANL 122

Query: 120 QLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNN 179
            LGFAADER+F +CAD+F+LLG+ +VRLLTNNP K++ + +AGIN+VER+PL VG N  N
Sbjct: 123 ALGFAADERNFKVCADIFELLGICKVRLLTNNPAKIDTMKKAGINVVERIPLNVGENRYN 182

Query: 180 EHYLDTKAEKMGHLL 194
             YLDTKA+KMGH +
Sbjct: 183 TGYLDTKAKKMGHYI 197


>UniRef50_O84736 GTP cyclohydrolase-2 n=38 Tax=Bacteria RepID=RIBBA_CHLTR
          Length = 424

 Score =  295 bits (755), Expect = 7e-79,   Method: Composition-based stats.
 Identities = 100/194 (51%), Positives = 132/194 (68%), Gaps = 1/194 (0%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           + +++ A+LPT +GDF +  +E +  G  H ALV GDI     V  RVHSECLTGD L S
Sbjct: 211 VTKISSARLPTKYGDFSIHVYESIIDGTQHFALVKGDIHEQEAVPVRVHSECLTGDILGS 270

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
            RCDCG QL+ A+  IAEEG G+++Y R QEGR IG  +KIRAYALQD GYDTV+AN QL
Sbjct: 271 CRCDCGAQLDMAMRYIAEEGLGVIVYLRGQEGRGIGFGHKIRAYALQDLGYDTVDANLQL 330

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181
           GF  D R++ + A + K L +  VRL+T+NP+K   L   GI++++R+ L V  +  NE 
Sbjct: 331 GFPIDAREYGMAAQVLKDLQLTSVRLITHNPRKFFELQRLGIHVLDRIILPVSISTENEG 390

Query: 182 YLDTKAEKMGHLLN 195
           YL TK E+MGH L+
Sbjct: 391 YLRTKKERMGHWLD 404


>UniRef50_Q4QNX8 GTP cyclohydrolase-2 n=78 Tax=cellular organisms RepID=RIBA_HAEI8
          Length = 216

 Score =  294 bits (754), Expect = 8e-79,   Method: Composition-based stats.
 Identities = 132/194 (68%), Positives = 158/194 (81%), Gaps = 1/194 (0%)

Query: 2   QLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDIS-GHTPVLARVHSECLTGDAL 60
           +++ VA+A LPT +G F MVGFE   T  +HVALV GDIS    PVLAR+HSECLTGDAL
Sbjct: 3   KIQLVAQANLPTEYGIFKMVGFEFPDTKKEHVALVMGDISNADEPVLARIHSECLTGDAL 62

Query: 61  FSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQ 120
            SL+CDCGFQL  AL QI EEGRG+L+YHR+EGR IGL+NKIRAY+LQD+G DT+EAN  
Sbjct: 63  HSLKCDCGFQLATALKQIQEEGRGVLIYHREEGRGIGLINKIRAYSLQDKGMDTIEANLA 122

Query: 121 LGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNE 180
           LGF ADER+F +CADMF+LLGV +VRL+TNNP+KVE + +AGIN+VERVPL VG N  N 
Sbjct: 123 LGFKADERNFEVCADMFELLGVKKVRLMTNNPEKVETMKKAGINVVERVPLNVGENRYNT 182

Query: 181 HYLDTKAEKMGHLL 194
            YLDTKA+KMGH +
Sbjct: 183 KYLDTKAKKMGHYI 196


>UniRef50_C4Z7I1 GTP cyclohydrolase II / 3,4-dihydroxy 2-butanone 4-phosphate
           synthase n=19 Tax=Bacteria RepID=C4Z7I1_EUBE2
          Length = 400

 Score =  294 bits (754), Expect = 9e-79,   Method: Composition-based stats.
 Identities = 103/193 (53%), Positives = 131/193 (67%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           ++ VA  ++PT +G+F    +     G  HVALV GDI   + +L RVHSECLTGDA  S
Sbjct: 206 VECVAVTRMPTKYGEFTAHCYVNKLNGEHHVALVKGDIGDGSNLLCRVHSECLTGDAFGS 265

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
           ++CDCG QL +A+TQI  EGRG+LLY RQEGR IGL+NK++AYALQDQG DT+EAN  LG
Sbjct: 266 MKCDCGQQLASAMTQINNEGRGVLLYMRQEGRGIGLVNKLKAYALQDQGMDTLEANLALG 325

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHY 182
              D R++ + A + K LG   +RLLTNNP KV  L + GI I ERVP+ +     +  Y
Sbjct: 326 LPGDAREYYIGAQILKDLGAKSLRLLTNNPDKVYQLADFGIEISERVPIEIDATSFDRFY 385

Query: 183 LDTKAEKMGHLLN 195
           L TK  KMGH+LN
Sbjct: 386 LKTKQTKMGHILN 398


>UniRef50_P47924 GTP cyclohydrolase-2 n=36 Tax=cellular organisms RepID=RIBBA_ARATH
          Length = 543

 Score =  294 bits (753), Expect = 1e-78,   Method: Composition-based stats.
 Identities = 91/192 (47%), Positives = 123/192 (64%), Gaps = 1/192 (0%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           ++R + A++PT WG F    +  +  G +H+A+V G+I     +L RVHSECLTGD   S
Sbjct: 333 VERASAARIPTMWGPFTAYCYRSILDGIEHIAMVKGEIGDGQDILVRVHSECLTGDIFGS 392

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
            RCDCG QL  ++ QI   GRG+L+Y R  EGR IGL +K+RAY LQD G DTVEAN +L
Sbjct: 393 ARCDCGNQLALSMQQIEATGRGVLVYLRGHEGRGIGLGHKLRAYNLQDAGRDTVEANEEL 452

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181
           G   D R++ + A + + LGV  ++L+TNNP K   L   G+ IV RVPL+      N+ 
Sbjct: 453 GLPVDSREYGIGAQIIRDLGVRTMKLMTNNPAKYVGLKGYGLAIVGRVPLLSLITKENKR 512

Query: 182 YLDTKAEKMGHL 193
           YL+TK  KMGH+
Sbjct: 513 YLETKRTKMGHM 524


>UniRef50_C4GH90 GTP cyclohydrolase-2 n=1 Tax=Kingella oralis ATCC 51147
           RepID=C4GH90_9NEIS
          Length = 235

 Score =  293 bits (750), Expect = 3e-78,   Method: Composition-based stats.
 Identities = 111/192 (57%), Positives = 148/192 (77%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           L+ +   +LPT  G + M G+++  TG +H+ALV GDI+   PVL+RVHSECLTGDALFS
Sbjct: 42  LQHITSCRLPTEHGIYQMHGYQDSQTGQEHIALVMGDITTPEPVLSRVHSECLTGDALFS 101

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
            +CDCG QL+AA+  +A EGRG+++Y RQEGR IGL+NKIRAYALQD+G DTVEAN  LG
Sbjct: 102 QKCDCGPQLKAAMQAVAAEGRGVIVYLRQEGRGIGLINKIRAYALQDKGMDTVEANLALG 161

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHY 182
              D RDFTL  +++  LG+  +RLLTNNP+KV  L +AGI+I ER+PL VG +P N++Y
Sbjct: 162 LPVDARDFTLAKEIYDHLGIRSIRLLTNNPEKVHTLQQAGIHITERLPLHVGIHPENQNY 221

Query: 183 LDTKAEKMGHLL 194
           L+TKA+K+ H++
Sbjct: 222 LNTKAQKLNHMM 233


>UniRef50_A1T8K1 GTP cyclohydrolase-2 n=43 Tax=cellular organisms RepID=RIBBA_MYCVP
          Length = 423

 Score =  292 bits (748), Expect = 5e-78,   Method: Composition-based stats.
 Identities = 106/198 (53%), Positives = 132/198 (66%), Gaps = 5/198 (2%)

Query: 2   QLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISG----HTPVLARVHSECLTG 57
            + RVAEA++PT  G+F  VG+  +    +HVALV G+ISG       VL RVHSECLTG
Sbjct: 208 HIARVAEARIPTRHGEFRAVGYTSIYEDVEHVALVKGEISGPHSDGHDVLVRVHSECLTG 267

Query: 58  DALFSLRCDCGFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVE 116
           D   S RCDCG QL+AAL  +A EGRG++LY R  EGR IGL++K++AY LQD G DTV+
Sbjct: 268 DVFGSRRCDCGPQLDAALAMVAREGRGVVLYMRGHEGRGIGLMHKLQAYQLQDAGDDTVD 327

Query: 117 ANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRN 176
           AN +LG  AD RD+   A +   LGV  +RLLTNNP K   L   G++I+ERVPL V  N
Sbjct: 328 ANLKLGLPADARDYGTGAQILVDLGVRSMRLLTNNPAKRVGLDGYGLHIIERVPLPVRAN 387

Query: 177 PNNEHYLDTKAEKMGHLL 194
             N  YL TK ++MGH L
Sbjct: 388 AENIRYLMTKRDRMGHDL 405


>UniRef50_A0PPL6 GTP cyclohydrolase-2 n=82 Tax=Bacteria RepID=RIBBA_MYCUA
          Length = 425

 Score =  291 bits (745), Expect = 1e-77,   Method: Composition-based stats.
 Identities = 103/199 (51%), Positives = 132/199 (66%), Gaps = 5/199 (2%)

Query: 2   QLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDI----SGHTPVLARVHSECLTG 57
            ++RVAEA++PT  G+F  +G+  +    +HVALV G+I    S    VL RVHSECLTG
Sbjct: 208 HIERVAEARIPTRRGEFRAIGYTSIYENVEHVALVRGEIAGPNSDGDDVLVRVHSECLTG 267

Query: 58  DALFSLRCDCGFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVE 116
           D   S RCDCG QL+AA+  +A EGRG++LY R  EGR IGLL+K++ Y LQD G DTV+
Sbjct: 268 DVFGSRRCDCGSQLDAAMAMVAREGRGVVLYMRGHEGRGIGLLHKLQTYQLQDAGDDTVD 327

Query: 117 ANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRN 176
           AN +LG  AD RD+ + A +   LGV  +RLLTNNP K   L   G++I+ERVPL V  N
Sbjct: 328 ANLKLGLPADARDYGIGAQILVDLGVRSMRLLTNNPAKRVGLDGYGLHIIERVPLPVRAN 387

Query: 177 PNNEHYLDTKAEKMGHLLN 195
             N  YL TK ++MGH L 
Sbjct: 388 AENIRYLMTKRDRMGHDLT 406


>UniRef50_P57863 GTP cyclohydrolase-2 n=17 Tax=Proteobacteria RepID=RIBA_PASMU
          Length = 219

 Score =  290 bits (743), Expect = 2e-77,   Method: Composition-based stats.
 Identities = 127/194 (65%), Positives = 159/194 (81%), Gaps = 1/194 (0%)

Query: 2   QLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISG-HTPVLARVHSECLTGDAL 60
           +++RV EA LPT +G F +VGFE   T  +HVALV G++     P+LAR+HSECLTGDAL
Sbjct: 3   KIQRVTEANLPTEFGMFRIVGFEFPDTKKEHVALVLGEVENTDEPILARIHSECLTGDAL 62

Query: 61  FSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQ 120
           +SL+CDCGFQL AAL QI++EGRG+L+YHR+EGR IGL+NKIRAY+LQD+G DT+EAN  
Sbjct: 63  YSLKCDCGFQLAAALRQISQEGRGVLIYHREEGRGIGLINKIRAYSLQDKGMDTIEANLA 122

Query: 121 LGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNE 180
           LGFAADER+F +CAD+F LLG+N+VRLLTNNP K++ + +AGINIVERV L VG N  N 
Sbjct: 123 LGFAADERNFEVCADIFALLGINKVRLLTNNPNKIDTMKKAGINIVERVALNVGENRYNT 182

Query: 181 HYLDTKAEKMGHLL 194
            YLDTKA+KMGH +
Sbjct: 183 EYLDTKAKKMGHFI 196


>UniRef50_Q5F7N6 GTP cyclohydrolase-2 n=33 Tax=Bacteria RepID=RIBA_NEIG1
          Length = 197

 Score =  290 bits (742), Expect = 2e-77,   Method: Composition-based stats.
 Identities = 118/194 (60%), Positives = 145/194 (74%), Gaps = 1/194 (0%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           L  VA  +LPT WG F M GFEE A G +HVAL  G+ S   PVL R+HSECLTGDALFS
Sbjct: 5   LDHVASCRLPTEWGVFTMHGFEE-ANGQEHVALTVGNCSDGNPVLTRIHSECLTGDALFS 63

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
            +CDCG QLEAA+  +  EGRGI++Y RQEGR IGL+NKIRAY LQ+QG DTVEAN  LG
Sbjct: 64  RKCDCGPQLEAAMRAVQAEGRGIIVYLRQEGRGIGLINKIRAYHLQEQGMDTVEANLALG 123

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHY 182
              D RDF L   +++ LG+  V+LLTNNP+K++ L +AGIN+VER+PL VG N  NE Y
Sbjct: 124 LPVDARDFRLAQSIYEYLGIRSVKLLTNNPEKIQTLKDAGINVVERIPLHVGENLENERY 183

Query: 183 LDTKAEKMGHLLNK 196
           L TKA+K+GHL+++
Sbjct: 184 LQTKADKLGHLMSE 197


>UniRef50_C0VNE9 GTP cyclohydrolase-2 n=2 Tax=Moraxellaceae RepID=C0VNE9_9GAMM
          Length = 252

 Score =  289 bits (741), Expect = 3e-77,   Method: Composition-based stats.
 Identities = 114/197 (57%), Positives = 144/197 (73%), Gaps = 1/197 (0%)

Query: 1   MQLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYG-DISGHTPVLARVHSECLTGDA 59
           + ++ +A +KLPT +GDF +  F++  TG +HVAL  G + + + PVL R+HSECLTGDA
Sbjct: 53  VPIEFIATSKLPTAFGDFNISVFQDPETGEEHVALSKGLETAPNQPVLVRIHSECLTGDA 112

Query: 60  LFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANH 119
             SL+CDCG QL+A    I E G+G++LY RQEGR IGL NKIRAYALQDQG+DTV+AN 
Sbjct: 113 FASLKCDCGPQLQATQRLINEAGQGVILYLRQEGRGIGLTNKIRAYALQDQGHDTVDANL 172

Query: 120 QLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNN 179
            L   AD R + +C+ M   L V EV+LLTNNP K++ LT+ GIN+VERVPL VGRNP N
Sbjct: 173 LLNLPADARRYDMCSIMLDHLQVKEVKLLTNNPLKLKALTDLGINVVERVPLTVGRNPFN 232

Query: 180 EHYLDTKAEKMGHLLNK 196
           EHYL TK E+M HL  K
Sbjct: 233 EHYLKTKRERMDHLYKK 249


>UniRef50_C9KJZ5 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
           n=1 Tax=Mitsuokella multacida DSM 20544
           RepID=C9KJZ5_9FIRM
          Length = 403

 Score =  284 bits (728), Expect = 9e-76,   Method: Composition-based stats.
 Identities = 99/192 (51%), Positives = 124/192 (64%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           +  VA+   P+ +G F +  +E        +A+V GD+ G   VL RVHSECLTGDAL S
Sbjct: 206 VHEVADVDFPSKYGHFRIHAYENELNNKCDIAIVKGDVRGKKDVLVRVHSECLTGDALGS 265

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
           +RCDCG QL  AL +I  EG G++LY RQEGR IGL NK+RAYALQD+G DTVEAN +LG
Sbjct: 266 MRCDCGDQLALALKKIEAEGEGVVLYMRQEGRGIGLANKMRAYALQDKGRDTVEANVELG 325

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHY 182
           FA D RD+ + A +   LG+  +RL+TNNP K   L   G+ I  RVPL V  N  ++ Y
Sbjct: 326 FAPDLRDYGIGAQILADLGLTSIRLMTNNPAKRAGLEGYGLEITGRVPLQVHANKFDKRY 385

Query: 183 LDTKAEKMGHLL 194
           L  K  KMGHL 
Sbjct: 386 LTVKKVKMGHLF 397


>UniRef50_C5CJ14 GTP cyclohydrolase II n=1 Tax=Kosmotoga olearia TBF 19.5.1
           RepID=C5CJ14_KOSOT
          Length = 390

 Score =  281 bits (719), Expect = 1e-74,   Method: Composition-based stats.
 Identities = 100/194 (51%), Positives = 125/194 (64%), Gaps = 1/194 (0%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           +K V+ A LPT +G F +V FE      +H A++YGDIS   PV  R+HSECLTGDAL S
Sbjct: 194 VKVVSIASLPTKFGTFQIVSFENNYDFLEHTAIIYGDIS-KEPVPVRIHSECLTGDALGS 252

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
           LRCDCG QL+ A+  I  +GRGI+LY RQEGR IGL NKI+AY LQD G DTV+AN  LG
Sbjct: 253 LRCDCGSQLQNAMRYIKSQGRGIVLYLRQEGRGIGLHNKIKAYHLQDNGMDTVDANIALG 312

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHY 182
           F  D RD+ + A M + LGV ++ LL+NNP K+  L    I + E   +     P N  Y
Sbjct: 313 FPEDMRDYGVAAQMLRALGVKKIILLSNNPDKLRQLKHYQIIVDETRNIFGEITPYNHFY 372

Query: 183 LDTKAEKMGHLLNK 196
           L TK E+MGH   +
Sbjct: 373 LKTKMERMGHTFEE 386


>UniRef50_Q13NP8 GTP cyclohydrolase-2 n=9 Tax=cellular organisms RepID=Q13NP8_BURXL
          Length = 224

 Score =  280 bits (718), Expect = 1e-74,   Method: Composition-based stats.
 Identities = 98/191 (51%), Positives = 124/191 (64%), Gaps = 1/191 (0%)

Query: 7   AEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCD 66
           A A LPT +G F    F    +G +H+ALV GD++  + VL R+HSECLTGD L S RCD
Sbjct: 32  ATATLPTRYGTFTSYVFRVCESGAEHLALVMGDVANKSSVLTRLHSECLTGDVLGSYRCD 91

Query: 67  CGFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAA 125
           CG QL+ AL  IA EG G+LLY R  EGR IGL NKIRAYALQ+QG DTVEAN  LG   
Sbjct: 92  CGEQLDLALRYIAAEGCGVLLYLRGHEGRGIGLSNKIRAYALQEQGRDTVEANLDLGLPD 151

Query: 126 DERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDT 185
           D R++   A + + L V  VRL++NNP+K + L++ GI + ERV L +     NE Y+ T
Sbjct: 152 DSREYDSAAGILRTLKVTSVRLMSNNPEKFDTLSKHGIPVCERVALAIPMREENERYIRT 211

Query: 186 KAEKMGHLLNK 196
           K  K GH  ++
Sbjct: 212 KQVKFGHYFDE 222


>UniRef50_D2RDK3 GTP cyclohydrolase II n=2 Tax=Archaeoglobaceae RepID=D2RDK3_ARCPR
          Length = 376

 Score =  278 bits (713), Expect = 5e-74,   Method: Composition-based stats.
 Identities = 99/194 (51%), Positives = 130/194 (67%), Gaps = 6/194 (3%)

Query: 3   LKRVAEAKLPTPW-GDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALF 61
           ++RV  A LPT + G F  VG++      + VALV G++S    VL R+HSECLTGD   
Sbjct: 183 VERVVSATLPTKFYGTFKAVGYKTPLG--EIVALVKGNVS-EGDVLVRIHSECLTGDVFH 239

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVEANHQ 120
           SLRCDCG QLE AL +I EEG+G+L+Y R  EGR IGL+NK+ AY LQ++G DTVEAN +
Sbjct: 240 SLRCDCGEQLERALKKIDEEGKGVLIYMRGHEGRGIGLINKLMAYKLQEEGKDTVEANVE 299

Query: 121 LGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNE 180
           LGF  D R + + A +   LGV  VRL+TNNP K+E L + G  +V R P+++     N+
Sbjct: 300 LGFPPDLRSYGIAAQILMDLGVKSVRLMTNNPNKIEELKKYGFKVV-REPIVIEPVEENK 358

Query: 181 HYLDTKAEKMGHLL 194
            YL TK EKMGH++
Sbjct: 359 KYLKTKMEKMGHMI 372


>UniRef50_C8WEC3 GTP cyclohydrolase-2 n=10 Tax=Sphingomonadales RepID=C8WEC3_ZYMMN
          Length = 364

 Score =  278 bits (713), Expect = 5e-74,   Method: Composition-based stats.
 Identities = 105/199 (52%), Positives = 133/199 (66%), Gaps = 8/199 (4%)

Query: 3   LKRVAEAKLPTPWGDF-------LMVGFEELATGHDHVALVYGDISGHTPVLARVHSECL 55
           +   A A+LP   GD         +V F   A   +HVA++ G   G  PV  R+HSECL
Sbjct: 167 VYIAARARLPIALGDHGKAIENSQIVAFRNDADAVEHVAVIIGHPDGQPPV-VRLHSECL 225

Query: 56  TGDALFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTV 115
           TGD   SL+CDCG QL  AL  + E G GILLY RQEGR IGL+NK+RAY+LQDQG+DTV
Sbjct: 226 TGDVFGSLKCDCGPQLHQALRIMDESGYGILLYLRQEGRGIGLINKLRAYSLQDQGFDTV 285

Query: 116 EANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGR 175
           +AN +LGF  D RDF L A M   L + ++RLLTNNP KVE L +AGI++VER+PL +  
Sbjct: 286 DANVRLGFVNDARDFRLAAQMLGELEIKQIRLLTNNPDKVEGLKKAGIDVVERLPLKIKP 345

Query: 176 NPNNEHYLDTKAEKMGHLL 194
           NP+N+ YL+TK ++ GH L
Sbjct: 346 NPHNQAYLETKRDRSGHQL 364


>UniRef50_UPI0001905AE1 GTP cyclohydrolase II protein n=1 Tax=Rhizobium etli 8C-3
           RepID=UPI0001905AE1
          Length = 222

 Score =  276 bits (706), Expect = 3e-73,   Method: Composition-based stats.
 Identities = 96/196 (48%), Positives = 133/196 (67%), Gaps = 1/196 (0%)

Query: 2   QLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALF 61
           ++KR A++ +PT +GDF  + + +  TG +H+AL  G++     VL RVHSECLTG+A  
Sbjct: 1   RVKRYAQSFMPTRFGDFKAIAYRDSLTGTEHLALTLGELCEKEDVLVRVHSECLTGEAFR 60

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVEANHQ 120
           S+RCDCG QLE AL  +   G G ++Y R QEGR IGL NKI AY+LQD G DT+EAN +
Sbjct: 61  SMRCDCGQQLEMALRAVQLAGAGCVIYMRGQEGRGIGLGNKIAAYSLQDHGRDTLEANRE 120

Query: 121 LGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNE 180
           LGFA+D R++   AD+ + LG+  VRLLTNNP K+E L  +G+ +  R  LI   + +N 
Sbjct: 121 LGFASDSREYNAAADIIRDLGIGSVRLLTNNPTKIEALRTSGVIVSSRQSLIAASSASNI 180

Query: 181 HYLDTKAEKMGHLLNK 196
            YL TK ++ GHLL++
Sbjct: 181 TYLKTKRDRFGHLLDQ 196


>UniRef50_D2R1R5 GTP cyclohydrolase II n=3 Tax=Planctomycetaceae RepID=D2R1R5_9PLAN
          Length = 403

 Score =  273 bits (700), Expect = 2e-72,   Method: Composition-based stats.
 Identities = 94/195 (48%), Positives = 130/195 (66%), Gaps = 3/195 (1%)

Query: 3   LKRVAEAKLPT-PWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALF 61
           + R+A+A++PT  +GDF ++ +E        V LV GD++     L R+HS C TGD L 
Sbjct: 206 VTRIAQAQIPTGQFGDFTIIAYEVKFETQTPVVLVKGDLTSVEAPLVRLHSSCFTGDLLD 265

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
           SLRCDCG QL+ AL  I +E  G+L+Y  QEGR IGL+ KI+AY LQ++G DTVEAN  L
Sbjct: 266 SLRCDCGDQLKKALEMIRDEKVGVLVYLPQEGRGIGLVEKIKAYDLQERGLDTVEANTAL 325

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAG--INIVERVPLIVGRNPNN 179
           G+ AD RD+ +   + K LG+++VRL+TNNPKK +     G  + +V++VP+I   NP+N
Sbjct: 326 GYKADMRDYGVGIQILKDLGLSKVRLMTNNPKKTDAFIYGGFSLEVVDQVPIITESNPHN 385

Query: 180 EHYLDTKAEKMGHLL 194
             YL TK +KMGH L
Sbjct: 386 AKYLATKRDKMGHKL 400


>UniRef50_Q1D4N5 GTP cyclohydrolase-2 n=6 Tax=Cystobacterineae RepID=Q1D4N5_MYXXD
          Length = 224

 Score =  272 bits (697), Expect = 4e-72,   Method: Composition-based stats.
 Identities = 95/194 (48%), Positives = 125/194 (64%)

Query: 2   QLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALF 61
            L+R +EA +PT  G    + F +   G +HVALV G +SGH  V  R+HSECLT +   
Sbjct: 18  HLERFSEADIPTERGSLRTIVFRDKRNGREHVALVVGQVSGHEGVPVRIHSECLTSEVFG 77

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
           SL+CDC  QL+ +L  I + G+G++LY RQEGR IGL NKI+AYALQ +G DT EAN QL
Sbjct: 78  SLKCDCREQLDRSLDFITQAGQGVVLYLRQEGRGIGLGNKIKAYALQSKGLDTYEANRQL 137

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181
           GFA D R + + A+M + L V  V L+TNNP K+  + E GI +  R+P     NP+N  
Sbjct: 138 GFADDLRTYDIAAEMLRSLDVRSVDLMTNNPLKIAGMVEEGIPVRRRIPSRTEHNPHNVD 197

Query: 182 YLDTKAEKMGHLLN 195
           YL TK E+ GHL+ 
Sbjct: 198 YLRTKRERTGHLIE 211


>UniRef50_O29766 GTP cyclohydrolase-2 n=1 Tax=Archaeoglobus fulgidus
           RepID=RIBA_ARCFU
          Length = 378

 Score =  272 bits (697), Expect = 4e-72,   Method: Composition-based stats.
 Identities = 96/194 (49%), Positives = 122/194 (62%), Gaps = 6/194 (3%)

Query: 3   LKRVAEAKLPTPW-GDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALF 61
           ++RV EA LPT + G F  VG++      + VALV G +     VL R+HSECLTGD   
Sbjct: 185 VERVIEATLPTKFYGTFRAVGYKTPLG--EIVALVKGRVD-EGDVLVRIHSECLTGDVFH 241

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVEANHQ 120
           SLRCDCG QLE AL  I  EG+G+ +Y R  EGR IGL+NK+ AY LQ++G DTV+AN +
Sbjct: 242 SLRCDCGDQLENALKMIDREGKGVAIYMRGHEGRGIGLINKLMAYKLQEEGKDTVDANIE 301

Query: 121 LGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNE 180
           LGF  D R + + A +   L V  +RLLTNNP K+E L + G  IV R P+ V     N 
Sbjct: 302 LGFPPDMRSYGIAAQILMDLKVKSIRLLTNNPLKIEELKKYGFKIV-REPIEVEPCEVNL 360

Query: 181 HYLDTKAEKMGHLL 194
            YL  K +KMGHL+
Sbjct: 361 PYLKAKKDKMGHLI 374


>UniRef50_B8JBX2 GTP cyclohydrolase-2 n=5 Tax=Bacteria RepID=B8JBX2_ANAD2
          Length = 248

 Score =  272 bits (695), Expect = 7e-72,   Method: Composition-based stats.
 Identities = 97/185 (52%), Positives = 124/185 (67%)

Query: 11  LPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQ 70
           LPT  G F +V F       +HVALV+GD+ G   V  R+HSECLTGD + SLRCDC  Q
Sbjct: 38  LPTRAGPFRIVAFWNNRDAKEHVALVHGDVVGAADVPVRLHSECLTGDVMGSLRCDCRDQ 97

Query: 71  LEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDF 130
           L   L  I  EGRG+LLY RQEGR IGL+NKIRAYALQ+QG DTVEAN  LGF  DERD+
Sbjct: 98  LTEGLAAIQREGRGVLLYLRQEGRGIGLINKIRAYALQEQGLDTVEANLALGFRDDERDY 157

Query: 131 TLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAEKM 190
            + A M   L +  +RL+TNNP+K+  LT   +++  R+P ++    +N  YL+TKA + 
Sbjct: 158 AVAAHMIHGLELRSIRLITNNPEKIRQLTAYRVDVSGRIPHVIPPGEHNRFYLETKARRS 217

Query: 191 GHLLN 195
           GHL++
Sbjct: 218 GHLID 222


>UniRef50_D1BH22 GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase
           n=4 Tax=Bacteria RepID=D1BH22_SANKS
          Length = 464

 Score =  270 bits (691), Expect = 2e-71,   Method: Composition-based stats.
 Identities = 99/196 (50%), Positives = 126/196 (64%), Gaps = 3/196 (1%)

Query: 2   QLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALV-YGDISGHTPVLARVHSECLTGDAL 60
           ++   + A+LPT  GDF + G+ +L TG +HVALV  G        + RVHSECLTGDA 
Sbjct: 223 RVHATSVAELPTAHGDFRVHGYRDLRTGAEHVALVPVGVEHPEEVPVVRVHSECLTGDAF 282

Query: 61  FSLRCDCGFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVEANH 119
            SLRCDCG QLEA++  +A EG G ++Y R  EGR IGLL KI AY LQD G DTV+AN 
Sbjct: 283 GSLRCDCGPQLEASMEIVAREG-GAVVYLRGHEGRGIGLLAKIAAYELQDAGRDTVQANL 341

Query: 120 QLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNN 179
            LG+ AD R++   A +   LG+  VRLLTNNP K   L   G+ + E V + VG + +N
Sbjct: 342 DLGWPADRREYGGAAAILVDLGLQRVRLLTNNPAKSTGLAAHGVEVTETVRIEVGHSQHN 401

Query: 180 EHYLDTKAEKMGHLLN 195
           E YL TK E MGH+L+
Sbjct: 402 ERYLRTKKELMGHVLD 417


>UniRef50_D0LLG6 GTP cyclohydrolase-2 n=1 Tax=Haliangium ochraceum DSM 14365
           RepID=D0LLG6_HALO1
          Length = 214

 Score =  270 bits (690), Expect = 3e-71,   Method: Composition-based stats.
 Identities = 97/194 (50%), Positives = 127/194 (65%)

Query: 1   MQLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDAL 60
           + L++ A +KLPT  G F +  +       + +A+  G  +   P   RVHSEC TG+ L
Sbjct: 12  VSLEKYATSKLPTIHGQFEVTVYRYGPDSEEALAVTLGSFAPDEPTFVRVHSECYTGEVL 71

Query: 61  FSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQ 120
            SL+CDC  QLE ALT+I E GRG+L+Y RQEGR IGL NKIRAYALQDQG DTV+ANHQ
Sbjct: 72  GSLKCDCREQLELALTRIQELGRGVLVYLRQEGRGIGLGNKIRAYALQDQGADTVQANHQ 131

Query: 121 LGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNE 180
           LGFA D R+F + A++ K LGV  + L TNNP+K++ + + GI +V R P     NP+N 
Sbjct: 132 LGFATDLREFDVAAEILKDLGVARIHLHTNNPEKIQAMEDHGIELVSREPAHGVINPHNR 191

Query: 181 HYLDTKAEKMGHLL 194
            YL+TK   +GH  
Sbjct: 192 RYLETKHHTLGHDF 205


>UniRef50_Q9X2E6 GTP cyclohydrolase-2 n=13 Tax=cellular organisms RepID=RIBBA_THEMA
          Length = 388

 Score =  267 bits (684), Expect = 1e-70,   Method: Composition-based stats.
 Identities = 98/194 (50%), Positives = 123/194 (63%), Gaps = 3/194 (1%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           +K+ AEA LPT +G F +V FE    G +H A+V   +    PV  R+HSEC+TGD L S
Sbjct: 191 MKKKAEATLPTDFGVFKVVSFENHLDGKEHFAIVKEPL--EDPVAVRIHSECVTGDVLSS 248

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
           LRCDCG QL   L  ++  G GIL+Y RQEGR IGL NKI AY+LQD+G DTVEAN  LG
Sbjct: 249 LRCDCGSQLANFLRYMSAHG-GILIYLRQEGRGIGLSNKIAAYSLQDKGLDTVEANRVLG 307

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHY 182
           F+ DERD+   A + K LG+  V L TNN +K   L + GI +VE   L     P+N  Y
Sbjct: 308 FSEDERDYAPAAQILKALGIERVLLFTNNQRKTVGLEKYGIEVVETKRLYGRVTPHNRFY 367

Query: 183 LDTKAEKMGHLLNK 196
           L TK +K+GH L +
Sbjct: 368 LSTKMKKLGHELEE 381


>UniRef50_B0RC63 Riboflavin biosynthesis protein RibA n=7 Tax=Actinomycetales
           RepID=B0RC63_CLAMS
          Length = 453

 Score =  267 bits (683), Expect = 1e-70,   Method: Composition-based stats.
 Identities = 93/192 (48%), Positives = 130/192 (67%), Gaps = 3/192 (1%)

Query: 2   QLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALF 61
           ++    E  +PT  G   +  + +  TG DHVA+V G+   H   L RVHSECLTG+AL 
Sbjct: 219 RVIFEVETTVPTTHGSVKLRAYRDRTTGADHVAIVAGEPRAHG-TLVRVHSECLTGEALG 277

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVEANHQ 120
           SL+C+CG QL+AAL +I  +G G+++Y R  EGR IGL+NK+RAY LQ+ G+DT++AN  
Sbjct: 278 SLKCECGPQLDAALDEIQRDG-GVVVYLRGHEGRGIGLINKLRAYRLQEDGFDTLDANVA 336

Query: 121 LGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNE 180
           LG  AD RD+   + + + +G+ +VRLLTNNP+KV  L   G+ + ERVPL+VG N  N 
Sbjct: 337 LGLPADARDYGAASAILQEMGIEDVRLLTNNPEKVRQLEAHGVEVTERVPLVVGVNEVNA 396

Query: 181 HYLDTKAEKMGH 192
            YL+TK ++MGH
Sbjct: 397 GYLETKRDRMGH 408


>UniRef50_Q1GKN3 GTP cyclohydrolase-2 n=44 Tax=Rhodobacterales RepID=Q1GKN3_SILST
          Length = 362

 Score =  266 bits (681), Expect = 3e-70,   Method: Composition-based stats.
 Identities = 106/192 (55%), Positives = 131/192 (68%), Gaps = 5/192 (2%)

Query: 6   VAEAKLP---TPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           VA A+LP   +  G   +  F     G +H A+  G      PVLAR+HS C TGD L S
Sbjct: 173 VAAARLPMEASEAG--RLHIFRPEDGGEEHYAIEIGRPDRSQPVLARLHSACFTGDVLGS 230

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
           L+CDCG QL  AL+ + +EG GILLY  QEGR IGL NK+RAY+LQDQG+DTVEANH+LG
Sbjct: 231 LKCDCGPQLRGALSHMGQEGAGILLYLNQEGRGIGLANKMRAYSLQDQGFDTVEANHRLG 290

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHY 182
           F  DERDF L A + + LG + VRL+TNNP K+ ++ + GI++VERVPL VG N  N HY
Sbjct: 291 FEDDERDFRLGASILRELGFSSVRLMTNNPGKIAMMEKTGISVVERVPLKVGENAFNRHY 350

Query: 183 LDTKAEKMGHLL 194
           L TKA K GH+L
Sbjct: 351 LATKAAKSGHML 362


>UniRef50_Q6GFT5 GTP cyclohydrolase-2 n=76 Tax=Bacteria RepID=RIBBA_STAAR
          Length = 393

 Score =  266 bits (681), Expect = 3e-70,   Method: Composition-based stats.
 Identities = 91/193 (47%), Positives = 122/193 (63%), Gaps = 3/193 (1%)

Query: 2   QLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALF 61
           +++  A+ K+PT +G F M GF+   T  + V L  G I  H     R+HS CLTGD   
Sbjct: 204 EIEFKAKVKMPTDFGTFDMYGFKATYTDEEIVVLTKGAIRQHEN--VRLHSACLTGDIFH 261

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
           S RCDCG QLE+++  I E G G+++Y  QEGR IGLLNK+RAY L +QGYDTV AN  L
Sbjct: 262 SQRCDCGAQLESSMKYINEHG-GMIIYLPQEGRGIGLLNKLRAYELIEQGYDTVTANLAL 320

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181
           GF  D RD+ + A + K   +  + LL+NNP K E L + GI+I ER+ +IV    +N  
Sbjct: 321 GFDEDLRDYHIAAQILKYFNIEHINLLSNNPSKFEGLKQYGIDIAERIEVIVPETVHNHD 380

Query: 182 YLDTKAEKMGHLL 194
           Y++TK  KMGHL+
Sbjct: 381 YMETKKIKMGHLI 393


>UniRef50_Q4L7B1 GTP cyclohydrolase-2 n=3 Tax=Staphylococcus RepID=RIBBA_STAHJ
          Length = 393

 Score =  265 bits (679), Expect = 4e-70,   Method: Composition-based stats.
 Identities = 91/193 (47%), Positives = 120/193 (62%), Gaps = 3/193 (1%)

Query: 2   QLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALF 61
            ++  A+  +PT  G F M GFE   T  + V L  G+         R+HS CLTGD   
Sbjct: 204 SVELKAKVNMPTDHGAFEMYGFESSLTKEEIVVLAKGEPRVTEN--VRIHSACLTGDIFH 261

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
           S RCDCG QLE+A+  I E G G+++Y  QEGR IGL+NK+RAY L +QG+DTV AN  L
Sbjct: 262 SQRCDCGAQLESAMKYINEHG-GMIIYLPQEGRGIGLINKLRAYELIEQGHDTVTANLAL 320

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181
           GF  D RD+ + A +     V +V LL+NNPKK E L+E GI + +R P+IV  N +N  
Sbjct: 321 GFDEDLRDYHIAAQILNYFNVQQVNLLSNNPKKFEGLSEYGIKVADRTPIIVAENEHNHD 380

Query: 182 YLDTKAEKMGHLL 194
           Y++TK  KMGHL+
Sbjct: 381 YMNTKKIKMGHLI 393


>UniRef50_Q4FV65 GTP cyclohydrolase-2 n=3 Tax=Psychrobacter RepID=Q4FV65_PSYA2
          Length = 230

 Score =  264 bits (676), Expect = 1e-69,   Method: Composition-based stats.
 Identities = 108/220 (49%), Positives = 133/220 (60%), Gaps = 26/220 (11%)

Query: 1   MQLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYG-------DISGHTP-------- 45
           M  + +  AKLPT  G+F +  FE    G +HV L  G       D +   P        
Sbjct: 1   MSYQFITSAKLPTRHGEFDIHIFEN-DEGQEHVMLTVGLPVVDQTDTTDSLPSPDTILNQ 59

Query: 46  ----------VLARVHSECLTGDALFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRN 95
                      L R+HSECLTGDA  SL+CDCG QL  A+  I E G G +LY RQEGR 
Sbjct: 60  EDNALSERPIPLIRIHSECLTGDAFSSLKCDCGPQLNTAMHAIQETGCGAILYLRQEGRG 119

Query: 96  IGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKV 155
           IGL NKIRAYALQDQG+DT++AN  LG  AD R + +C  M   +GV+ VRL+TNNP KV
Sbjct: 120 IGLTNKIRAYALQDQGHDTLDANLMLGLPADARIYDMCGPMLAHIGVDAVRLITNNPSKV 179

Query: 156 EILTEAGINIVERVPLIVGRNPNNEHYLDTKAEKMGHLLN 195
             LTE GI+++ERVPL+VG N  N  YL TK ++MGHLL+
Sbjct: 180 AYLTEHGIDVIERVPLVVGVNDMNAEYLATKRDRMGHLLD 219


>UniRef50_P43525 GTP cyclohydrolase-2 n=6 Tax=Alphaproteobacteria RepID=RIBA_AZOBR
          Length = 385

 Score =  263 bits (674), Expect = 2e-69,   Method: Composition-based stats.
 Identities = 100/193 (51%), Positives = 131/193 (67%), Gaps = 1/193 (0%)

Query: 3   LKRVAEAKLPTPWGDFL-MVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALF 61
           L+RVAEA++P    +   +  F  +  G +H+A++ G+     PVLAR+HSEC TGD L 
Sbjct: 193 LRRVAEARVPLSGAENTSIAAFRPIDGGPEHLAIIVGNPVAGEPVLARLHSECFTGDLLA 252

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
            LRCDCG QL  A+ +IA  G G+LLY  QEGR IGL+NK+RAY +QD+G+DTV+AN  L
Sbjct: 253 GLRCDCGQQLRGAIAEIARHGSGVLLYLAQEGRGIGLVNKLRAYRIQDRGFDTVDANEIL 312

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181
           GF ADER +   A+M + LG   VRL+TNNP+K+  L   GI +VERVP I   N +NE 
Sbjct: 313 GFEADERVYLPAAEMLRQLGFTAVRLMTNNPEKLRQLARCGIEVVERVPHIFPANGHNEG 372

Query: 182 YLDTKAEKMGHLL 194
           YL TKAE+ GH+ 
Sbjct: 373 YLRTKAERSGHMF 385


>UniRef50_A8IZV5 Bifunctional GTP cyclohydrolase II n=1 Tax=Chlamydomonas
           reinhardtii RepID=A8IZV5_CHLRE
          Length = 370

 Score =  263 bits (673), Expect = 2e-69,   Method: Composition-based stats.
 Identities = 84/195 (43%), Positives = 118/195 (60%), Gaps = 4/195 (2%)

Query: 6   VAEAKLPTPWGDFLMVGFEELATG----HDHVALVYGDISGHTPVLARVHSECLTGDALF 61
           +AE  LPT  G F + G++    G     +  A+V G + G   V  RVH  C T + L 
Sbjct: 86  IAETLLPTRHGKFRLRGYKHSTDGGATFTEPTAIVSGKVEGQEDVAVRVHDACFTSEVLG 145

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
           SL+CDC  QLE AL  I     GI++Y +QEGR IGL NKI AY+LQ+QG DTV+AN  L
Sbjct: 146 SLKCDCAEQLELALRMIQGAPPGIVIYLQQEGRGIGLANKIAAYSLQEQGLDTVDANRAL 205

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181
           G   D R++T   +M + +GV  +RL+TNNP+K+  LT+ GI +  R+P +V     N+ 
Sbjct: 206 GLPDDCREYTSVRNMLQDMGVKSIRLITNNPRKINTLTKLGIQVNGRIPCLVAAGAYNQG 265

Query: 182 YLDTKAEKMGHLLNK 196
           YL+ K ++M H+L +
Sbjct: 266 YLEAKRDRMAHMLPE 280


>UniRef50_C0YM11 GTP cyclohydrolase-2 n=2 Tax=Chryseobacterium gleum ATCC 35910
           RepID=C0YM11_9FLAO
          Length = 198

 Score =  260 bits (665), Expect = 2e-68,   Method: Composition-based stats.
 Identities = 88/194 (45%), Positives = 130/194 (67%), Gaps = 2/194 (1%)

Query: 3   LKRVAEAKLPTPWGDFLMVGF-EELATGHDHVALVYGDISGHTPVLARVHSECLTGDALF 61
           +K  AEA +PT  G F M+ F E       H+A++  +     PV  R HSEC+TG+   
Sbjct: 2   IKIQAEANVPTEHGTFRMIAFSENENDWMPHMAIIAENTDFSKPVNVRFHSECITGEVFH 61

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
           S +C+CG QL+AA+  I E G GI++Y RQEGRNIG++NK++AY+LQ++G DTV+AN QL
Sbjct: 62  SKKCECGQQLDAAMKYIHENG-GIIIYLRQEGRNIGIINKLKAYSLQEKGLDTVQANLQL 120

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181
           G  AD+R+F +  ++  LL V ++ LLTNNP+KV+ + ++ I++  RVPL +  N  ++ 
Sbjct: 121 GLPADDRNFGVAIEILNLLDVKDINLLTNNPEKVKYVVDSNIHLNSRVPLQIPANEISKG 180

Query: 182 YLDTKAEKMGHLLN 195
           YL TK +  GHLL+
Sbjct: 181 YLQTKKDFFGHLLD 194


>UniRef50_A6C5C2 Riboflavin biosynthesis protein RibA n=1 Tax=Planctomyces maris DSM
           8797 RepID=A6C5C2_9PLAN
          Length = 416

 Score =  260 bits (664), Expect = 2e-68,   Method: Composition-based stats.
 Identities = 94/195 (48%), Positives = 125/195 (64%), Gaps = 3/195 (1%)

Query: 3   LKRVAEAKLPTP-WGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALF 61
           + R  E  + T  +G   ++G+         VALV+GD+      L R+HS C TGD L 
Sbjct: 216 VHREVEVPINTKNYGTVQVIGYSVEHESQQPVALVWGDLHSVEAPLVRMHSSCFTGDLLD 275

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
           SLRCDCG QL  A++ I + G G ++Y  QEGR IGL+ K++AY LQDQGYDTVEAN QL
Sbjct: 276 SLRCDCGDQLHMAMSAINQAGAGAVVYLPQEGRGIGLIPKLKAYVLQDQGYDTVEANIQL 335

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEI--LTEAGINIVERVPLIVGRNPNN 179
           GF AD RDFT+   + K LG+ +VRLLTNNPKK +    T   + +VE+VP++   + + 
Sbjct: 336 GFKADSRDFTVGVQILKDLGLTKVRLLTNNPKKTDSDVYTGFNLEVVEQVPIVAPPHKDR 395

Query: 180 EHYLDTKAEKMGHLL 194
           E YL TK +KMGH+L
Sbjct: 396 EFYLQTKRDKMGHIL 410


>UniRef50_Q1IPQ1 GTP cyclohydrolase-2 n=4 Tax=Bacteria RepID=Q1IPQ1_ACIBL
          Length = 224

 Score =  260 bits (664), Expect = 3e-68,   Method: Composition-based stats.
 Identities = 99/213 (46%), Positives = 128/213 (60%), Gaps = 21/213 (9%)

Query: 2   QLKRVAEAKLPTPWGDFLMVGFEELATG--------------------HDHVALVYGDIS 41
            + ++AEA  PT WG F + GFE                            VALV GDI 
Sbjct: 12  HVIKMAEADFPTRWGRFRIYGFEGTFEEVPDSASANDLARDGVIERRKESAVALVMGDIH 71

Query: 42  GHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNK 101
              P L R+HS+CLTGD   S RCDC  QLE AL  I++ G G+L+Y  QEGR IGL+ K
Sbjct: 72  -SQPPLVRIHSQCLTGDVFGSQRCDCRQQLELALQMISDAGNGVLIYEEQEGRGIGLMAK 130

Query: 102 IRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEA 161
           ++AY LQD+G DTVEAN QLG  AD R +TL  ++ K LG+  +RLL+NNP+KV+ + +A
Sbjct: 131 LQAYELQDKGLDTVEANEQLGLKADYRQYTLPVEIMKALGITRLRLLSNNPEKVKAVEDA 190

Query: 162 GINIVERVPLIVGRNPNNEHYLDTKAEKMGHLL 194
           GI +VERV   V   P ++ YL TK +KMGH+ 
Sbjct: 191 GIEVVERVSAEVEAYPTSKAYLQTKKDKMGHIF 223


>UniRef50_UPI000050F87F bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP
           cyclohydrolase II protein n=1 Tax=Brevibacterium linens
           BL2 RepID=UPI000050F87F
          Length = 464

 Score =  258 bits (661), Expect = 5e-68,   Method: Composition-based stats.
 Identities = 96/208 (46%), Positives = 123/208 (59%), Gaps = 18/208 (8%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYG--------DISGHTP------VLA 48
           ++  AE  LPT  G F    F     GHDH+ +  G        + +G  P       L 
Sbjct: 240 IEASAEVPLPTKHGSFSARAF--TIDGHDHLGVFSGIDSAAVAHEPAGQEPSLHGPAPLV 297

Query: 49  RVHSECLTGDALFSLRCDCGFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYAL 107
           RVHSECLTGD   S RCDCG QL+ AL QI++EG G ++Y    EGR IGL NK+RAYAL
Sbjct: 298 RVHSECLTGDVFGSHRCDCGEQLDLALQQISDEG-GTVIYMTGHEGRGIGLSNKLRAYAL 356

Query: 108 QDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVE 167
           QD+G DTV+AN +LGF  D+RD+   A++ + +G+  +RLLTNNP K   L   GI I  
Sbjct: 357 QDRGLDTVDANRELGFHDDDRDYRAAAEILRSIGLTHIRLLTNNPDKTRALESLGITIEA 416

Query: 168 RVPLIVGRNPNNEHYLDTKAEKMGHLLN 195
            VPL +   P N +YL+TK E+M H L 
Sbjct: 417 VVPLEIPARPENSNYLNTKRERMHHTLT 444


>UniRef50_A9FWS8 GTP cyclohydrolase-2 n=1 Tax=Sorangium cellulosum 'So ce 56'
           RepID=A9FWS8_SORC5
          Length = 225

 Score =  257 bits (658), Expect = 1e-67,   Method: Composition-based stats.
 Identities = 96/200 (48%), Positives = 120/200 (60%), Gaps = 7/200 (3%)

Query: 2   QLKRVAEAKLPTPWGDFLMVGFE-------ELATGHDHVALVYGDISGHTPVLARVHSEC 54
           QL   A+A +PT  G F M+ F        +     DHVALV GD+ G + V  RVHSEC
Sbjct: 11  QLDIRAQAPVPTKHGVFQMLVFHFGGTTSPDQGLSPDHVALVMGDVRGRSDVTLRVHSEC 70

Query: 55  LTGDALFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDT 114
           LT +   SL+CDC  QLEAA  +I   G G++LY RQEGR IGL NKIRAY LQ  G+DT
Sbjct: 71  LTSEVFGSLKCDCREQLEAAQAEIGRRGLGVVLYLRQEGRGIGLANKIRAYQLQAFGHDT 130

Query: 115 VEANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVG 174
           V+AN  LG   D R +   A M + LG+  +RLLTNNP KV+ L   G+ I  R   IV 
Sbjct: 131 VDANRILGLPDDARGYEPAAAMIEHLGIESIRLLTNNPDKVDALRALGVRIASRSAAIVP 190

Query: 175 RNPNNEHYLDTKAEKMGHLL 194
            NP +  YL+ K  +MGH++
Sbjct: 191 ANPFSAPYLEAKRLRMGHVI 210


>UniRef50_C7JCF3 Bifunctional protein 3,4-dihydroxy-2-butanone 4-phosphate
           synthase/GTP cyclohydrolase II n=8 Tax=Acetobacter
           pasteurianus RepID=C7JCF3_ACEP3
          Length = 437

 Score =  256 bits (655), Expect = 3e-67,   Method: Composition-based stats.
 Identities = 97/198 (48%), Positives = 129/198 (65%), Gaps = 5/198 (2%)

Query: 3   LKRVAEAKLPTPWG--DFLMVGFEELATGHDHVALVYGDISGHTPV-LARVHSECLTGDA 59
           +  +A+A LP+ +G  D ++  +++   G +HVALV GD+     V L R+HSEC+TGDA
Sbjct: 229 VPDLAQASLPSAYGGDDLVIHAYQDE-NGVEHVALVKGDVRRKGAVPLVRLHSECVTGDA 287

Query: 60  LFSLRCDCGFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVEAN 118
           L SLRCDCG QL AAL  I +   G+L+Y R  EGR IGL+NKIRAY LQD G DTV+AN
Sbjct: 288 LGSLRCDCGSQLHAALRAIGKAECGVLVYVRGHEGRGIGLVNKIRAYELQDAGLDTVDAN 347

Query: 119 HQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPN 178
           H+LGFA D RD+   + + + LGV E+ LLTNNP KV  L   G  +  R+ L +   P+
Sbjct: 348 HRLGFATDARDWRAASGILRSLGVGELDLLTNNPDKVRALEARGFMVRRRIGLEIPPTPH 407

Query: 179 NEHYLDTKAEKMGHLLNK 196
           N  YL+ K  +MGH L +
Sbjct: 408 NRAYLEAKRRRMGHHLGQ 425


>UniRef50_C9MTM9 GTP cyclohydrolase-2 n=1 Tax=Prevotella veroralis F0319
           RepID=C9MTM9_9BACT
          Length = 205

 Score =  255 bits (653), Expect = 4e-67,   Method: Composition-based stats.
 Identities = 88/196 (44%), Positives = 128/196 (65%), Gaps = 1/196 (0%)

Query: 1   MQLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVL-ARVHSECLTGDA 59
           +++ +  +  +PT WGDF M+ F     G D   +  G++     +   R+HS C +GD 
Sbjct: 4   IKVVKGEKVHMPTIWGDFFMIPFHNEDDGKDCFVVGKGNVLNSVNIPIVRIHSSCSSGDI 63

Query: 60  LFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANH 119
           L SLRCDCG QL  AL  I ++G G+L+Y  QEGR IGL++K++AY LQ+QG DTV+AN 
Sbjct: 64  LGSLRCDCGEQLHKALKLIEQKGEGLLIYLNQEGRGIGLMDKMKAYKLQEQGVDTVDANL 123

Query: 120 QLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNN 179
           Q+G + DERD+ + A + KLLG++E+ LLTNN  K + L   GIN+ + +PL    N  N
Sbjct: 124 QIGHSVDERDYAIGAAILKLLGISEIDLLTNNLLKSQGLIRNGINVRKIIPLETSPNKYN 183

Query: 180 EHYLDTKAEKMGHLLN 195
           + YL+TK ++MGHLL+
Sbjct: 184 KFYLETKKKRMGHLLH 199


>UniRef50_A7I3X0 GTP cyclohydrolase-2 n=6 Tax=cellular organisms RepID=RIBA_CAMHC
          Length = 193

 Score =  255 bits (653), Expect = 5e-67,   Method: Composition-based stats.
 Identities = 92/195 (47%), Positives = 124/195 (63%), Gaps = 7/195 (3%)

Query: 1   MQLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDAL 60
           M ++    AKLP+ +G F +  F+E     +H+ ++        PV  R+HSECLTGDA+
Sbjct: 1   MNIEISNVAKLPSRFGMFKVQAFKE--DEKEHLVIIKEPYK--EPVNIRIHSECLTGDAI 56

Query: 61  FSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQ 120
            SL+CDC  QLE +L  I + G G+++Y RQEGRNIGL NKI AY LQD+G DT+EANHQ
Sbjct: 57  GSLKCDCRDQLEESLKFIEKNG-GMVIYLRQEGRNIGLFNKINAYNLQDKGLDTIEANHQ 115

Query: 121 LGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNE 180
           LGF  DER + +   + K   +  + LLTNNPKK+  L    + +  RVP+I+  N  NE
Sbjct: 116 LGFKTDERTYEIVDFILKYYKIKSINLLTNNPKKLMGL--HNVKVAARVPIIIKPNKFNE 173

Query: 181 HYLDTKAEKMGHLLN 195
            YL TK  +MGHLL+
Sbjct: 174 KYLQTKKNEMGHLLD 188


>UniRef50_B9L8K1 GTP cyclohydrolase-2 n=3 Tax=Bacteria RepID=B9L8K1_NAUPA
          Length = 185

 Score =  255 bits (653), Expect = 5e-67,   Method: Composition-based stats.
 Identities = 101/192 (52%), Positives = 126/192 (65%), Gaps = 7/192 (3%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           +K    A LPT +G F +  F+E     +H+A+    +        R+HSECLTGDAL S
Sbjct: 1   MKISDIATLPTKYGIFKIQSFKE--NDKEHLAIFTEKL--PEIPYIRIHSECLTGDALGS 56

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
           L+CDCG QL  AL  I E G GI+LY RQEGR IGL NK+ AYALQD+G DTVEANHQLG
Sbjct: 57  LKCDCGDQLAFALKTINEHG-GIVLYLRQEGRGIGLFNKVNAYALQDKGLDTVEANHQLG 115

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHY 182
           F AD RDF++   + K  G+ +++LLTNNPKK        I +VER+P+ V  NP NE+Y
Sbjct: 116 FEADMRDFSIVEKILKHFGIKQIKLLTNNPKKEFAFK--NIKVVERIPVKVEPNPYNENY 173

Query: 183 LDTKAEKMGHLL 194
           L TK EK+GH L
Sbjct: 174 LKTKKEKLGHKL 185


>UniRef50_A0RR75 GTP cyclohydrolase-2 n=10 Tax=Epsilonproteobacteria
           RepID=RIBA_CAMFF
          Length = 195

 Score =  255 bits (652), Expect = 6e-67,   Method: Composition-based stats.
 Identities = 91/196 (46%), Positives = 130/196 (66%), Gaps = 4/196 (2%)

Query: 1   MQLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDAL 60
           M++ +   A LP+ +G F +  ++E     +H+ +   ++     V  R+HSECLTGDA+
Sbjct: 1   MEIIKSNIANLPSRFGKFQIKSYKE-GCCKEHLTIFSPNLDVTKTVNVRIHSECLTGDAI 59

Query: 61  FSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQ 120
            SL+CDC  QLEA+L  I + G G+++Y RQEGRNIGLLNK+ AYALQD G DT+EANHQ
Sbjct: 60  GSLKCDCRDQLEASLKYINKHG-GMVIYLRQEGRNIGLLNKVNAYALQDNGLDTIEANHQ 118

Query: 121 LGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNE 180
           LGF ADER + +   + K  G+  + LLTNNP K+  LT   +NI +R+P+ +  N  N+
Sbjct: 119 LGFKADERTYEIVDFILKDFGIKSINLLTNNPLKLASLT--CVNIEKRIPIEIESNEFNK 176

Query: 181 HYLDTKAEKMGHLLNK 196
            YL  K E+MGH+L++
Sbjct: 177 DYLKVKKEQMGHMLDE 192


>UniRef50_C1E155 Predicted protein n=2 Tax=Micromonas RepID=C1E155_9CHLO
          Length = 357

 Score =  255 bits (651), Expect = 7e-67,   Method: Composition-based stats.
 Identities = 86/196 (43%), Positives = 119/196 (60%), Gaps = 5/196 (2%)

Query: 4   KRVAEAKLPTPWGDFLMVGFEELATGH---DHVALVYGDISGHTPVLARVHSECLTGDAL 60
           + +AE KLPT  G + + G+     G    + VA+ +GDI G   V  RVH  C T + L
Sbjct: 126 EFIAETKLPTGSGFYRLRGYRHSVDGGVPSEPVAICFGDIEGREKVPVRVHDACFTSEVL 185

Query: 61  FSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQD-QGYDTVEANH 119
            SL+CDC  QL+ A+  I E   G+++Y  QEGR IGL NKI AYALQD QG DTV+AN 
Sbjct: 186 GSLKCDCKQQLQLAMEYIQEN-DGMVIYLHQEGRGIGLANKIAAYALQDTQGLDTVDANR 244

Query: 120 QLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNN 179
            LG   D R++T  A++ + +G+  ++L+TNNP+KV  L   G+ I  R+P IV  N  N
Sbjct: 245 ALGLPDDVREYTAVANILEDMGIRSIQLMTNNPRKVATLERLGVKIEGRIPCIVKANLFN 304

Query: 180 EHYLDTKAEKMGHLLN 195
           + YL+ K  +M H L+
Sbjct: 305 QGYLEAKEGRMKHFLD 320


>UniRef50_A4XHM6 GTP cyclohydrolase II n=2 Tax=Clostridia RepID=A4XHM6_CALS8
          Length = 402

 Score =  254 bits (650), Expect = 1e-66,   Method: Composition-based stats.
 Identities = 80/192 (41%), Positives = 115/192 (59%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           +++ AEA LPT +G F +  F+   +  +H  L+    +   PV  R+HS C TGD   S
Sbjct: 200 VQKEAEANLPTQYGKFKIFVFKNYFSQKEHAVLINQTFNPSQPVNVRIHSSCKTGDVFHS 259

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
           LRCDC  QLE  L  +AE    +L+Y  QEGR IG  NKI+AYALQ+QG+DT EAN+ LG
Sbjct: 260 LRCDCHQQLEFFLHFMAENKNCMLIYLDQEGRGIGFANKIKAYALQEQGFDTYEANNLLG 319

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHY 182
           F  D RD+     + +  G+ ++ L T+NP+KV  L + GI I++R+ + +  NP N  Y
Sbjct: 320 FDDDLRDYFDALHILRFFGIKKINLATSNPEKVSFLQDLGIEILKRISIPIVINPYNRKY 379

Query: 183 LDTKAEKMGHLL 194
           + +K  K  H +
Sbjct: 380 IHSKILKKKHEI 391


>UniRef50_A0JVK1 GTP cyclohydrolase-2 n=2 Tax=Micrococcaceae RepID=A0JVK1_ARTS2
          Length = 237

 Score =  254 bits (649), Expect = 1e-66,   Method: Composition-based stats.
 Identities = 94/188 (50%), Positives = 118/188 (62%), Gaps = 3/188 (1%)

Query: 9   AKLPTPWGDFLMVGFEELATGHDHVALVYG-DISGHTPVLARVHSECLTGDALFSLRCDC 67
            +LP+ +GDF+   + +L TG +H+A+            L R+HSECLTGD   S RCDC
Sbjct: 25  VQLPSEFGDFVAQAWTDLVTGAEHLAVSSPIPPVDGKAPLVRLHSECLTGDVFGSYRCDC 84

Query: 68  GFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAAD 126
           G QL  AL +I EEG G LLY R QEGR IGL NKI+AYALQ+ G+DTVEAN QLG   D
Sbjct: 85  GEQLAYALEKINEEG-GTLLYLRGQEGRGIGLANKIKAYALQEAGFDTVEANEQLGLPVD 143

Query: 127 ERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTK 186
            R +   A +   LG++EVRLL+NNP K   L +AG+ +VE VP  V     N  YL TK
Sbjct: 144 ARCYNAAAQILAELGLHEVRLLSNNPDKQNRLADAGVTVVEMVPTEVPSREQNIRYLQTK 203

Query: 187 AEKMGHLL 194
            ++M H L
Sbjct: 204 KDRMDHRL 211


>UniRef50_D0NCB5 Riboflavin biosynthesis protein ribBA, putative n=2
           Tax=Phytophthora infestans T30-4 RepID=D0NCB5_PHYIN
          Length = 367

 Score =  253 bits (648), Expect = 2e-66,   Method: Composition-based stats.
 Identities = 78/191 (40%), Positives = 116/191 (60%), Gaps = 3/191 (1%)

Query: 6   VAEAKLPTPWGDFLMVGFEEL--ATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSL 63
           VAE  LPT  G F +  +  +      + +A++ GD+ G   V  RVH +C T +   SL
Sbjct: 134 VAETALPTDGGMFRVRAYRSVGSLRESEPIAMITGDVRGKRNVPVRVHDQCFTSEVFGSL 193

Query: 64  RCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGF 123
           +CDC  QL+ A     + G G+++Y  QEGR IGL NKI AY++Q++G DTV+AN  LGF
Sbjct: 194 KCDCRDQLDYAKAYTKQHG-GVVIYMPQEGRGIGLANKIMAYSMQERGLDTVDANRVLGF 252

Query: 124 AADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYL 183
             D R +     + K LGV  +RLLTNNP+K+ +L++ GI +  R+P+++     ++ YL
Sbjct: 253 KDDYRSYEPVPAILKDLGVQSIRLLTNNPRKIRLLSQLGITVEGRLPVVIKGGEFSQGYL 312

Query: 184 DTKAEKMGHLL 194
             KA++M HLL
Sbjct: 313 TAKAKRMSHLL 323


>UniRef50_A5G2C3 GTP cyclohydrolase-2 n=2 Tax=Rhodospirillales RepID=A5G2C3_ACICJ
          Length = 384

 Score =  253 bits (646), Expect = 3e-66,   Method: Composition-based stats.
 Identities = 100/194 (51%), Positives = 133/194 (68%), Gaps = 1/194 (0%)

Query: 3   LKRVAEAKLPTPWG-DFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALF 61
           L RVAE  +P     D  +V F  L  G +H+A++ GD S     L R+HSEC TGD L 
Sbjct: 191 LHRVAEVAVPLDDAPDARLVAFRALDQGIEHMAILVGDPSAQAAPLVRIHSECFTGDLLG 250

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
           SLRCDCG QL+ A+ ++A+EG G++LY  QEGR IGL+NK+RAY LQD+G DTV+AN  L
Sbjct: 251 SLRCDCGPQLKGAIRRMAQEGGGVVLYLAQEGRGIGLINKLRAYTLQDRGLDTVDANRAL 310

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181
           G+ ADER+F + A M   LG++ +RLLTNNP+K   L   G+++VERVP ++  N  N+ 
Sbjct: 311 GWGADERNFHIAAAMLAALGLDHIRLLTNNPEKTAGLAACGVDVVERVPHVIAPNGVNDL 370

Query: 182 YLDTKAEKMGHLLN 195
           YL TKA + GHLL+
Sbjct: 371 YLATKARRFGHLLD 384


>UniRef50_A4RYG5 Predicted protein n=1 Tax=Ostreococcus lucimarinus CCE9901
           RepID=A4RYG5_OSTLU
          Length = 250

 Score =  253 bits (646), Expect = 3e-66,   Method: Composition-based stats.
 Identities = 84/195 (43%), Positives = 116/195 (59%), Gaps = 4/195 (2%)

Query: 6   VAEAKLPTPWGDFLMVGFEE----LATGHDHVALVYGDISGHTPVLARVHSECLTGDALF 61
           VAE KLPT  G + +  +           + V ++YGD+ G   V  RVH  C T + L 
Sbjct: 13  VAETKLPTDKGFYRVRAYRHANPTTGDVTEPVCVIYGDVEGRENVPVRVHDACFTSEVLG 72

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
           S++CDC  QLE A+  I E G GI+ Y +QEGR IGL NKI AYA+Q++G DTV+AN +L
Sbjct: 73  SMKCDCKQQLEMAMDYIKENGPGIVCYLQQEGRGIGLANKIAAYAVQEEGVDTVDANRRL 132

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181
           G   D R++T   +M + L V  V+L+TNNP+K+  L   GI I  R+  +V  N  NE 
Sbjct: 133 GLPDDTREYTAVENMLRELDVRSVQLMTNNPRKIRELECGGIKITGRIACVVKANLFNEG 192

Query: 182 YLDTKAEKMGHLLNK 196
           YL  K  +M H+L++
Sbjct: 193 YLAAKERRMSHVLDQ 207


>UniRef50_C6V5M6 GTP cyclohydrolase-2 n=2 Tax=Neorickettsia RepID=C6V5M6_NEORI
          Length = 353

 Score =  253 bits (646), Expect = 3e-66,   Method: Composition-based stats.
 Identities = 95/196 (48%), Positives = 126/196 (64%), Gaps = 5/196 (2%)

Query: 2   QLKRVAEAKLPTPWG-DFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDAL 60
            + RV+EAK+      D  MV +  +    +H A++ GD       L RVHS C TGD L
Sbjct: 158 HITRVSEAKIRIRENVDSYMVCYRSIL--KEHYAIIIGDPLSSQEPLVRVHSSCYTGDLL 215

Query: 61  FSLRCDCGFQLEAALTQIAEEG-RGILLYHRQEGRNIGLLNKIRAYALQ-DQGYDTVEAN 118
            SL CDC  QL   + +IAE+   GI+LY  QEGR IGL NKIRAY LQ D+G DTVEAN
Sbjct: 216 GSLSCDCRDQLHDTVKKIAEDPVGGIILYLSQEGRGIGLPNKIRAYNLQEDKGLDTVEAN 275

Query: 119 HQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPN 178
           + LGF  DERDF +   + K LG+ +VRL+TNNP+K+  L+ AG+++  RVP+++  NP 
Sbjct: 276 YCLGFKDDERDFRVVKLILKDLGIQKVRLITNNPEKIRQLSSAGVDVASRVPILMRSNPY 335

Query: 179 NEHYLDTKAEKMGHLL 194
           N  YL TK+EK+GH+ 
Sbjct: 336 NRKYLQTKSEKLGHIF 351


>UniRef50_B7IF97 A 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase
           II n=1 Tax=Thermosipho africanus TCF52B
           RepID=B7IF97_THEAB
          Length = 374

 Score =  252 bits (644), Expect = 5e-66,   Method: Composition-based stats.
 Identities = 96/189 (50%), Positives = 120/189 (63%), Gaps = 3/189 (1%)

Query: 7   AEAKLPTPWG-DFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRC 65
              KLPT    DF +  F+      +H+A+V        P L R+HSEC TGD   SLRC
Sbjct: 182 TSVKLPTAIDEDFDIYTFKNPYDSREHIAIVKRPFKESIPYL-RIHSECATGDIFHSLRC 240

Query: 66  DCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAA 125
           DCG QLE +L  I+++G G+L+Y RQEGR IGL NK++AY LQD+GYDTVEAN +LGF  
Sbjct: 241 DCGEQLENSLKIISKKG-GVLIYLRQEGRGIGLNNKVKAYKLQDEGYDTVEANLKLGFKD 299

Query: 126 DERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDT 185
           DERD+     + K L +NEV++LTNNPKK E L   GI I E V +    N  N+ YL T
Sbjct: 300 DERDYFAAYLILKALKINEVKILTNNPKKYEDLKRYGIKIKEIVNIYGKVNKYNKKYLFT 359

Query: 186 KAEKMGHLL 194
           KA+KM H L
Sbjct: 360 KAKKMKHNL 368


>UniRef50_C7NTK7 GTP cyclohydrolase II n=1 Tax=Halorhabdus utahensis DSM 12940
           RepID=C7NTK7_HALUD
          Length = 412

 Score =  252 bits (643), Expect = 7e-66,   Method: Composition-based stats.
 Identities = 101/195 (51%), Positives = 129/195 (66%), Gaps = 6/195 (3%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVY-GDISGHTP-VLARVHSECLTGDAL 60
           + R  + +LPT +G F M G+     G  HVALV   D+   T   L R+HS+CLTGDAL
Sbjct: 217 VSREVDTRLPTAFGTFDMYGY--DYRGETHVALVNLDDVDPETDRPLVRIHSKCLTGDAL 274

Query: 61  FSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQ 120
            SL+CDCGFQLE  + +I++EG G+LLY  QEGR IGLLNK++AY LQ+ GYDTVEAN +
Sbjct: 275 HSLKCDCGFQLEETMQRISDEG-GVLLYLDQEGRGIGLLNKLKAYELQEHGYDTVEANVE 333

Query: 121 LGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNE 180
           LGF  DER F   A M + +G++ VRLLTNNP+K   L     ++ E   L +  NP NE
Sbjct: 334 LGFEPDERRFDAAAQMLRDIGLDRVRLLTNNPRKAAALERFEFDV-EIDSLEIEPNPENE 392

Query: 181 HYLDTKAEKMGHLLN 195
            YL TKAEK+ H L+
Sbjct: 393 AYLATKAEKLDHQLD 407


>UniRef50_B8H6T8 GTP cyclohydrolase-2 n=1 Tax=Arthrobacter chlorophenolicus A6
           RepID=B8H6T8_ARTCA
          Length = 243

 Score =  251 bits (642), Expect = 8e-66,   Method: Composition-based stats.
 Identities = 94/188 (50%), Positives = 118/188 (62%), Gaps = 3/188 (1%)

Query: 9   AKLPTPWGDFLMVGFEELATGHDHVALVYGDI-SGHTPVLARVHSECLTGDALFSLRCDC 67
            +LPT +GDF+   + +L TG +H+A+   +  S     L R+HSECLTGD   S RCDC
Sbjct: 34  VQLPTAFGDFVAQAWTDLVTGVEHLAVSSPNPPSDGKAPLVRLHSECLTGDVFGSYRCDC 93

Query: 68  GFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAAD 126
           G QL  AL  I E G G LLY R QEGR IGL NKI+AYALQ+ G+DTVEAN QLG   D
Sbjct: 94  GEQLAYALELIHEHG-GTLLYLRGQEGRGIGLANKIKAYALQEAGFDTVEANEQLGLPVD 152

Query: 127 ERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTK 186
            R +   A +   +G++EVRLL+NNP K   L +AG+ +VE VP  V     N  YL TK
Sbjct: 153 ARCYKAAAQVLAEMGLHEVRLLSNNPDKQNRLAKAGVKVVEMVPTEVPSREQNIRYLRTK 212

Query: 187 AEKMGHLL 194
            ++M H L
Sbjct: 213 KDRMEHRL 220


>UniRef50_Q17XC9 GTP cyclohydrolase-2 n=13 Tax=Helicobacter RepID=RIBA_HELAH
          Length = 192

 Score =  250 bits (639), Expect = 2e-65,   Method: Composition-based stats.
 Identities = 91/195 (46%), Positives = 128/195 (65%), Gaps = 7/195 (3%)

Query: 2   QLKRVAEAKLPTPWGDFLMVGFEELAT--GHDHVALVYGDISGHTPVLARVHSECLTGDA 59
           +L+   +AKLPT +G+F +  F E  +    DH+ +    +      L R+HSECLTGDA
Sbjct: 3   RLEVSNQAKLPTQFGEFYIQCFREKNSNGSKDHLVIF--TLDFPENPLVRLHSECLTGDA 60

Query: 60  LFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANH 119
           L S +CDCG  L+ AL +I++EG G+++Y RQEGR IGL NK+ AYALQD+GYDT++AN 
Sbjct: 61  LGSQKCDCGVALQMALERISKEG-GLVIYLRQEGRGIGLFNKVNAYALQDKGYDTIQANE 119

Query: 120 QLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNN 179
            +GF  DERD+ +  ++ +   + ++RLLTNNPKK+  L +     V R  LIV  N +N
Sbjct: 120 MIGFKDDERDYGIAGEILEYYRIKKMRLLTNNPKKIAALEKY--AEVTRESLIVCANEHN 177

Query: 180 EHYLDTKAEKMGHLL 194
           + YL+ K  KMGHLL
Sbjct: 178 QGYLEVKKLKMGHLL 192


>UniRef50_C6X006 GTP cyclohydrolase-2 n=1 Tax=Flavobacteriaceae bacterium 3519-10
           RepID=C6X006_FLAB3
          Length = 204

 Score =  247 bits (630), Expect = 2e-64,   Method: Composition-based stats.
 Identities = 82/194 (42%), Positives = 128/194 (65%), Gaps = 2/194 (1%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELAT-GHDHVALVYGDISGHTPVLARVHSECLTGDALF 61
           LK  AEA +PT +G F ++   E       H+A+V  +     PV  R HSEC+TG+   
Sbjct: 2   LKIQAEANVPTEFGSFRIIALSETDNNWMPHLAIVAENTDFCQPVNVRFHSECITGEVFH 61

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
           S +C+CG QL+AA+  + E G GI++Y RQEGRNIG++NK++AY+LQ++G+DTVEAN +L
Sbjct: 62  SKKCECGQQLDAAMKYMHENG-GIIIYLRQEGRNIGIINKLKAYSLQEKGFDTVEANLEL 120

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181
           G  AD+R+F +  ++  +L V +V LLTNNP+K++++  + I++  R+PL +    ++  
Sbjct: 121 GLPADDRNFAVAVEILNILEVKDVNLLTNNPEKIKVVENSNIHLNSRIPLQISSTTDSAS 180

Query: 182 YLDTKAEKMGHLLN 195
           YL  K +  GH L+
Sbjct: 181 YLKVKKDFFGHFLD 194


>UniRef50_Q1QYD0 GTP cyclohydrolase-2 n=1 Tax=Chromohalobacter salexigens DSM 3043
           RepID=Q1QYD0_CHRSD
          Length = 378

 Score =  245 bits (626), Expect = 6e-64,   Method: Composition-based stats.
 Identities = 91/196 (46%), Positives = 118/196 (60%), Gaps = 2/196 (1%)

Query: 2   QLKRVAEAKLPTPWGD-FLMVGFEELATGHDHVALVYGDISG-HTPVLARVHSECLTGDA 59
            LKR++EA++P    D    V F E     +H+A++ GD +     V  R+HS CLTGD 
Sbjct: 164 SLKRISEAEIPLAEADRTRFVLFRESDGLREHLAVLVGDPAQWADAVPTRLHSACLTGDL 223

Query: 60  LFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANH 119
             SLRCDCG QL  ++  IAE G GILLY  QEGR IGL NK+RAY LQD G DTV+A+ 
Sbjct: 224 FGSLRCDCGEQLRGSVAAIAERGGGILLYLAQEGRGIGLANKLRAYHLQDDGLDTVDADQ 283

Query: 120 QLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNN 179
            LGF  DER + +   M + L V  + LLTNNP K++ ++  G+ +V R       N +N
Sbjct: 284 VLGFGDDERRYHVALQMLEALAVTRIELLTNNPGKIDAMSRGGVEVVGRQACYGKLNEHN 343

Query: 180 EHYLDTKAEKMGHLLN 195
             YL  KAE+ GH LN
Sbjct: 344 RRYLSAKAERAGHWLN 359


>UniRef50_A6G7P6 GTP cyclohydrolase-2 n=1 Tax=Plesiocystis pacifica SIR-1
           RepID=A6G7P6_9DELT
          Length = 194

 Score =  245 bits (625), Expect = 8e-64,   Method: Composition-based stats.
 Identities = 94/193 (48%), Positives = 120/193 (62%), Gaps = 1/193 (0%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGH-DHVALVYGDISGHTPVLARVHSECLTGDALF 61
           ++  A AKLP+  GD  +V F        D +A++ GDI+G + V  RVHSECLTGD   
Sbjct: 2   VRVYARAKLPSRHGDLEIVSFTTRDGQRIDDIAIIAGDITGKSAVPTRVHSECLTGDVFG 61

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
           SLRCDC  QLE A+ +I  EG G+++Y RQEGR IG+  K+RAY LQD G DT+EAN  L
Sbjct: 62  SLRCDCRDQLELAIDRICSEGVGLIVYMRQEGRGIGIAEKVRAYELQDSGLDTLEANVHL 121

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181
           GF  D R + + A M + L V+ V L TNNP+KVE L   G+ +  R  +I      N H
Sbjct: 122 GFDGDLRSYEVAASMIQALEVDSVVLFTNNPEKVEGLQANGVEVERREAIISESREENVH 181

Query: 182 YLDTKAEKMGHLL 194
           YL TK  KMGH+L
Sbjct: 182 YLMTKKAKMGHIL 194


>UniRef50_C4K9I6 GTP cyclohydrolase-2 n=1 Tax=Thauera sp. MZ1T RepID=C4K9I6_THASP
          Length = 385

 Score =  244 bits (624), Expect = 1e-63,   Method: Composition-based stats.
 Identities = 91/196 (46%), Positives = 122/196 (62%), Gaps = 2/196 (1%)

Query: 2   QLKRVAEAKLPTPWGDF-LMVGFEELATGHDHVALVYGDISG-HTPVLARVHSECLTGDA 59
           +L R++EA++P    +    V F E    H+HVA+V G+ +     V  R+HS CLTGD 
Sbjct: 164 RLARISEARVPLAEAENSRFVLFREADGVHEHVAIVIGERANWPEDVPVRLHSSCLTGDL 223

Query: 60  LFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANH 119
             SLRCDCG QL   +  I   G G+LLY  QEGR IGL NK+RAY LQD+G DT++A+ 
Sbjct: 224 FGSLRCDCGEQLRRGVAAIDALGGGVLLYLSQEGRGIGLANKLRAYGLQDEGLDTIDADQ 283

Query: 120 QLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNN 179
            +GF+ DERDF +  +M   LG++ + LLTNNP KV  L +AGI++V R  +       N
Sbjct: 284 VIGFSKDERDFRIAHEMLDELGIDRILLLTNNPSKVAALQKAGIHVVGRRAIYGEVTVQN 343

Query: 180 EHYLDTKAEKMGHLLN 195
           + YL TKA + GH LN
Sbjct: 344 QRYLRTKASRHGHWLN 359


>UniRef50_Q604R2 Riboflavin-specific deaminase/GTP cyclohydrolase II n=1
           Tax=Methylococcus capsulatus RepID=Q604R2_METCA
          Length = 355

 Score =  244 bits (623), Expect = 2e-63,   Method: Composition-based stats.
 Identities = 89/148 (60%), Positives = 103/148 (69%)

Query: 47  LARVHSECLTGDALFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYA 106
           LARVHSECLTGD   S RCDCG QLE AL  I E   G+LLY RQEGR IGL+ K+RAY 
Sbjct: 2   LARVHSECLTGDVFGSRRCDCGEQLELALRAIGEAECGVLLYLRQEGRGIGLVQKLRAYN 61

Query: 107 LQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIV 166
           LQD+G DTVEAN +LG  ADERD+ + A M + LGV  VRL+TNNPKK++ L   GI I 
Sbjct: 62  LQDEGLDTVEANLRLGHQADERDYHVAARMLEDLGVKSVRLMTNNPKKIDELRRYGIPIA 121

Query: 167 ERVPLIVGRNPNNEHYLDTKAEKMGHLL 194
            RVP+    +P N  YL  K EKM H+L
Sbjct: 122 ARVPIEAPSHPENVRYLRAKVEKMSHML 149


>UniRef50_Q83FM7 GTP cyclohydrolase-2 n=2 Tax=Tropheryma whipplei RepID=Q83FM7_TROWT
          Length = 211

 Score =  243 bits (622), Expect = 2e-63,   Method: Composition-based stats.
 Identities = 83/189 (43%), Positives = 116/189 (61%), Gaps = 4/189 (2%)

Query: 8   EAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDC 67
           E  LPT +G   + G+ ++    +H+AL+   I     VL R+HSEC+TG+   SL+CDC
Sbjct: 25  ETNLPTKFGTLRVRGYRDIKNN-EHIALITKQIK-SEDVLLRIHSECITGEVFMSLKCDC 82

Query: 68  GFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAAD 126
             QL  AL +I+ EG G+++Y R  EGR IG+LNK+RAY LQ+QG DT ++N +LG   D
Sbjct: 83  HGQLHKALERISAEG-GLVIYMRGHEGRGIGILNKLRAYRLQEQGLDTFDSNVKLGLPVD 141

Query: 127 ERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTK 186
            RD+   A++   LGV  VRLL+NNP K   L ++GI +   +P  VG    N  YL  K
Sbjct: 142 ARDYGPAAEILHDLGVRSVRLLSNNPDKQLQLEQSGIRVTGVLPWQVGLGKCNHEYLKVK 201

Query: 187 AEKMGHLLN 195
            +KMGH + 
Sbjct: 202 RDKMGHKIE 210


>UniRef50_B9ZQZ7 GTP cyclohydrolase-2 n=1 Tax=Thioalkalivibrio sp. K90mix
           RepID=B9ZQZ7_9GAMM
          Length = 381

 Score =  243 bits (622), Expect = 2e-63,   Method: Composition-based stats.
 Identities = 89/198 (44%), Positives = 120/198 (60%), Gaps = 2/198 (1%)

Query: 1   MQLKRVAEAKLPTPWGDF-LMVGFEELATGHDHVALVYGDISG-HTPVLARVHSECLTGD 58
           ++L  V+EA +P         + F E     +HVA+V G+ +     V  R+HS CLTGD
Sbjct: 175 LELAYVSEAPVPLADAPVTRFMLFREGNGILEHVAVVIGEPNEWPDAVPVRLHSACLTGD 234

Query: 59  ALFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEAN 118
              SLRCDCG QL   +  I E G G+LLY  QEGR IGL NK+RAY +Q  G DT++++
Sbjct: 235 LFGSLRCDCGDQLRLGVKTINESGGGVLLYLAQEGRGIGLANKLRAYTMQTAGLDTIDSD 294

Query: 119 HQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPN 178
            QLGF AD R +    +M + LG++ VR+LTNNP K+E L   GI +V R P+    NP+
Sbjct: 295 CQLGFEADGRRYDAAVEMLEFLGIDTVRVLTNNPAKIEALRAGGIRVVAREPVHGTLNPH 354

Query: 179 NEHYLDTKAEKMGHLLNK 196
           N  YL TKA++ GH L +
Sbjct: 355 NLRYLSTKADRGGHWLQE 372


>UniRef50_Q7VK48 GTP cyclohydrolase-2 n=2 Tax=Helicobacteraceae RepID=RIBA_HELHP
          Length = 194

 Score =  241 bits (616), Expect = 9e-63,   Method: Composition-based stats.
 Identities = 94/198 (47%), Positives = 125/198 (63%), Gaps = 8/198 (4%)

Query: 1   MQLKRVAEAKLPTPWGDFLMVGFEELATGH---DHVALVYGDISGHTPVLARVHSECLTG 57
           M+ +   +AKLPT +G+F    F E    +   +H+  V+    G TP L R+HSECLTG
Sbjct: 1   MKYEISEQAKLPTRFGNFFTKSFREYGKNNTLFEHLV-VFTHTLGETP-LVRIHSECLTG 58

Query: 58  DALFSLRCDCGFQLEAALTQIAEE-GRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVE 116
           D   S +CDCG +L  A+ QIA     G+L+Y RQEGR IGL NKI AYALQD+GYDTVE
Sbjct: 59  DVFGSKKCDCGNELALAMEQIAHNTEGGMLIYLRQEGRGIGLFNKINAYALQDKGYDTVE 118

Query: 117 ANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRN 176
           AN QLGFA D R + +  ++FK   +  + LLTNNP+K++ L       V R  +I   N
Sbjct: 119 ANQQLGFAGDMRSYEIVGEIFKHFHITHINLLTNNPRKIDALAPY--AKVVRHSIITPSN 176

Query: 177 PNNEHYLDTKAEKMGHLL 194
           P+N+ YL+ K +K+GHLL
Sbjct: 177 PHNQAYLEVKKQKLGHLL 194


>UniRef50_UPI000051036D riboflavin-specific deaminase/GTP cyclohydrolase II n=1
           Tax=Brevibacterium linens BL2 RepID=UPI000051036D
          Length = 473

 Score =  241 bits (615), Expect = 1e-62,   Method: Composition-based stats.
 Identities = 89/186 (47%), Positives = 107/186 (57%), Gaps = 3/186 (1%)

Query: 9   AKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCG 68
           +KLPT  G F +  F     G  H  +  GD +     L RVHSECLTGDAL S RCDCG
Sbjct: 19  SKLPTVHGLFTLRTFAH--DGTAHAVMSIGDPALVDAPLVRVHSECLTGDALGSHRCDCG 76

Query: 69  FQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADE 127
            QL A+L  IA+ G GIL+Y R  EGR IGL NK+RAYALQD G DTV AN  L    D 
Sbjct: 77  DQLSASLAAIAQAGDGILIYLRGHEGRGIGLENKLRAYALQDTGLDTVAANRALDLPDDA 136

Query: 128 RDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKA 187
           RD+T  A +   L   ++ LL++NP KV  L   GI + ER  L V   P +  YL+ K 
Sbjct: 137 RDYTGAAAILHDLDCPQITLLSSNPSKVTALEGMGITVAERRDLNVPDRPESAGYLEAKR 196

Query: 188 EKMGHL 193
             M H+
Sbjct: 197 RLMDHI 202


>UniRef50_A6VWW9 GTP cyclohydrolase-2 n=47 Tax=Bacteria RepID=RIBA_MARMS
          Length = 202

 Score =  240 bits (614), Expect = 1e-62,   Method: Composition-based stats.
 Identities = 91/197 (46%), Positives = 118/197 (59%), Gaps = 6/197 (3%)

Query: 3   LKRVAEAKLPTPWGDFLM--VGFEELATGHDHVALVYGDISGHTP---VLARVHSECLTG 57
           L       +P   GD +   + F    +G +H+ + +            L R+HSECLTG
Sbjct: 4   LTIKRRVMIPVRAGDVMAEFISFNGDDSGKEHIGIFFEGTKAKADNSIPLVRLHSECLTG 63

Query: 58  DALFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEA 117
           D   S RCDCG QL+ A+ +I EEG G +LY RQEGR IGL  K+ AYALQDQGYDT +A
Sbjct: 64  DVFGSGRCDCGEQLDEAIDRINEEG-GYILYLRQEGRGIGLYAKLEAYALQDQGYDTYQA 122

Query: 118 NHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNP 177
           N  L    D RDF + A+M + LGV++VRLLTNNP K + L E GI++ E VP  V  N 
Sbjct: 123 NEMLHLPDDGRDFGIAAEMLQALGVSKVRLLTNNPDKAQQLIEHGIDVAELVPTKVHVNQ 182

Query: 178 NNEHYLDTKAEKMGHLL 194
           +N  YL+TKA++  H L
Sbjct: 183 HNRSYLETKAKRKQHTL 199


>UniRef50_A6W477 GTP cyclohydrolase-2 n=8 Tax=Bacteria RepID=A6W477_KINRD
          Length = 206

 Score =  239 bits (611), Expect = 3e-62,   Method: Composition-based stats.
 Identities = 88/192 (45%), Positives = 106/192 (55%), Gaps = 6/192 (3%)

Query: 9   AKLPTPWGD-----FLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSL 63
             +P  + D       +  F  L  G +H+AL  GD    +  L R HSECLTGD   S 
Sbjct: 13  VDVPLRFADGYGTTARVHTFTGLVDGKEHLALGLGDWRQQSTPLVRPHSECLTGDVFGSE 72

Query: 64  RCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGF 123
           RCDCG QL  A+ +IA  G G LLY RQEGR IGL  K+ AYALQD G DT EAN  LG 
Sbjct: 73  RCDCGPQLREAVERIATTG-GFLLYLRQEGRGIGLYAKLDAYALQDSGLDTYEANLALGR 131

Query: 124 AADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYL 183
             DERD+ + A M   LGV  + LL+NNP K E L   GI +  RVP  V  + +N  YL
Sbjct: 132 GEDERDYAVAAQMLDALGVERIALLSNNPDKAEQLVRHGIAVERRVPTGVHLSASNARYL 191

Query: 184 DTKAEKMGHLLN 195
             K +   H L+
Sbjct: 192 RAKRDHTSHTLD 203


>UniRef50_A6DFW0 GTP cyclohydrolase-2 n=1 Tax=Lentisphaera araneosa HTCC2155
           RepID=A6DFW0_9BACT
          Length = 361

 Score =  239 bits (610), Expect = 5e-62,   Method: Composition-based stats.
 Identities = 75/194 (38%), Positives = 104/194 (53%), Gaps = 2/194 (1%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPV-LARVHSECLTGDALF 61
           ++     +L    G F +  F        H A V  +        L R+ SECLTG    
Sbjct: 168 IEMTGMTELDLQQGSFKLYSFYSEIDARYHWAFVCDEKKEEKKTPLVRIESECLTGHVFG 227

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQD-QGYDTVEANHQ 120
           SL CDCG QL   L +I E G G L+Y RQEGR IGL  K+ AY LQ   G DTV+AN  
Sbjct: 228 SLLCDCGDQLSKGLEEIKEYGYGALVYLRQEGRGIGLKAKLDAYYLQQFHGMDTVDANIA 287

Query: 121 LGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNE 180
           +G   D RD+ + A +   L    ++LLTNNP K+  L   G+++ ++V  I+  + +N+
Sbjct: 288 VGMPEDARDYLIGAQIINYLKFEPLKLLTNNPAKITGLNRYGLSVEQQVSHIIPPSKHNK 347

Query: 181 HYLDTKAEKMGHLL 194
            YLDTK ++MGH +
Sbjct: 348 RYLDTKRDRMGHRI 361


>UniRef50_B2GGU5 GTP cyclohydrolase-2 n=1 Tax=Kocuria rhizophila DC2201
           RepID=B2GGU5_KOCRD
          Length = 238

 Score =  238 bits (608), Expect = 8e-62,   Method: Composition-based stats.
 Identities = 86/200 (43%), Positives = 109/200 (54%), Gaps = 8/200 (4%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATG----HDHVALVYGDISGHTP--VLARVHSECLT 56
           L+      +PT  G F +VG+           +HV+L     +G      L R+HSECLT
Sbjct: 32  LEHSEPVTVPTDHGTFSVVGWRVPERSGAPATEHVSLSAPPPAGEEKLAPLVRLHSECLT 91

Query: 57  GDALFSLRCDCGFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTV 115
           GD   S RCDCG QL  AL +I   G G +LY R  EGR IGL+NK+RAY LQD G DTV
Sbjct: 92  GDVFGSWRCDCGPQLHLALERIHTHG-GTVLYLRNHEGRGIGLVNKLRAYKLQDAGADTV 150

Query: 116 EANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGR 175
           +AN  LG  A+ RD+T  A +   + +  VRLLTNNP KV  L   GI + + +   V  
Sbjct: 151 DANTMLGLPAEARDYTAAARILTAMNLTTVRLLTNNPDKVSKLEALGITVADVLAHEVSP 210

Query: 176 NPNNEHYLDTKAEKMGHLLN 195
              N  YL TK ++M H L 
Sbjct: 211 RTENVDYLRTKRDRMHHHLT 230


>UniRef50_A1SSA8 GTP cyclohydrolase-2 n=10 Tax=Gammaproteobacteria RepID=RIBA_PSYIN
          Length = 200

 Score =  237 bits (606), Expect = 1e-61,   Method: Composition-based stats.
 Identities = 84/196 (42%), Positives = 118/196 (60%), Gaps = 7/196 (3%)

Query: 1   MQLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISG-HTPVLARVHSECLTGDA 59
           + LK  A +++P       +  F  L +  +H+A+++G      +  + R+HSECLTGD 
Sbjct: 8   ISLKIGANSRIPA-----QIASFNGLTSDKEHIAIIFGKADECSSSPIVRIHSECLTGDV 62

Query: 60  LFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANH 119
             S RCDCG QL+ A+  + +EG GI++Y RQEGR IGL NKI AY LQ +G DT +AN+
Sbjct: 63  FHSSRCDCGEQLDEAIELMEKEG-GIIIYLRQEGRGIGLYNKIDAYKLQSEGMDTYQANN 121

Query: 120 QLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNN 179
           QLGF  D RDFT    M   L + +++LLTNNP KV+ L E GI + + +        +N
Sbjct: 122 QLGFEDDLRDFTEAGQMLAALNIRKLQLLTNNPLKVKALREYGITVDKVISTSTFIKDDN 181

Query: 180 EHYLDTKAEKMGHLLN 195
           E YL TKA+  GH + 
Sbjct: 182 ESYLRTKAKNAGHAIR 197


>UniRef50_D2NTM1 GTP cyclohydrolase II n=2 Tax=Rothia mucilaginosa
           RepID=D2NTM1_9MICC
          Length = 278

 Score =  237 bits (604), Expect = 2e-61,   Method: Composition-based stats.
 Identities = 90/203 (44%), Positives = 116/203 (57%), Gaps = 12/203 (5%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVL--------ARVHSEC 54
           ++   E  +PTP G F +  +   A G +H++    D    TPV          R+HSEC
Sbjct: 78  VESTEEVAVPTPQGLFGLRAWR-FADGAEHISARALD-RDGTPVPAEDGGALAVRIHSEC 135

Query: 55  LTGDALFSLRCDCGFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYD 113
            TGD   S RCDCG QLE  L  I   G G L+Y R  EGR IGL+NK+RAYALQD G D
Sbjct: 136 ATGDIFGSFRCDCGPQLENGLRIIGRTG-GYLIYVRNHEGRGIGLVNKLRAYALQDAGLD 194

Query: 114 TVEANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIV 173
           T++AN  LG   D RD++  A + + LGVNE+RL+TNNP K E L   G+ + E +P  +
Sbjct: 195 TLDANLALGLDGDMRDYSQAALILQELGVNELRLVTNNPAKQEALESLGLQVTELIPDEI 254

Query: 174 GRNPNNEHYLDTKAEKMGHLLNK 196
                N HYL TK E+M H+L  
Sbjct: 255 PARVENAHYLQTKRERMRHVLKS 277


>UniRef50_D2LG53 GTP cyclohydrolase II n=1 Tax=Rhodomicrobium vannielii ATCC 17100
           RepID=D2LG53_RHOVA
          Length = 383

 Score =  236 bits (603), Expect = 3e-61,   Method: Composition-based stats.
 Identities = 87/193 (45%), Positives = 115/193 (59%), Gaps = 1/193 (0%)

Query: 3   LKRVAEAKLPTP-WGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALF 61
           LK V+ A +P    G    V F       D +A++ G+ +   PV  R+HS CLTGD   
Sbjct: 170 LKIVSRAFVPLEGAGSCEFVVFRGGDGFRDQIAILVGNPTPGKPVSVRIHSACLTGDLFG 229

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
           SL+CDCG QL   +  +AEEG G +LY  QEGR  G+ NKIRAY LQDQG+DT +A+  L
Sbjct: 230 SLKCDCGEQLRGTVRAMAEEGGGAVLYLDQEGRGNGIANKIRAYRLQDQGFDTYDADELL 289

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181
           GF  D+R F   ADM +LLG   VRL+TNNP K++ L + G+N++    ++      N  
Sbjct: 290 GFGQDQRRFDFAADMLRLLGFTSVRLMTNNPLKIKALRDGGLNVLSTHRVLTRPTAQNVK 349

Query: 182 YLDTKAEKMGHLL 194
           YL  K +K GHLL
Sbjct: 350 YLAAKRDKAGHLL 362


>UniRef50_B3CNI0 GTP cyclohydrolase-2 n=13 Tax=Wolbachia RepID=B3CNI0_WOLPP
          Length = 361

 Score =  236 bits (602), Expect = 3e-61,   Method: Composition-based stats.
 Identities = 77/180 (42%), Positives = 111/180 (61%), Gaps = 1/180 (0%)

Query: 17  DFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALT 76
           +  ++ +   + G +H A++ G+       L R+HS C TGD L SL CDC  QL  A+ 
Sbjct: 180 EVDIISYRTKSGGREHYAIIIGNPDKDNEPLVRIHSACYTGDLLDSLSCDCRSQLHQAIQ 239

Query: 77  QIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQ-GYDTVEANHQLGFAADERDFTLCAD 135
            + + G GI+LY  Q+GR IGL NK+RAY++Q +   DTV+AN  LGF  DER F + A 
Sbjct: 240 IMTDFGNGIILYLMQDGRGIGLTNKLRAYSMQRKYNLDTVDANRVLGFEDDERSFAVAAK 299

Query: 136 MFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAEKMGHLLN 195
           + K L +N+++LLTNN +K+  L   GI + + VPLI+ RN  N  Y++TK  K+GH L 
Sbjct: 300 ILKKLNINKIQLLTNNGRKLSELKNNGIEVTKCVPLIMERNEYNHSYMETKFGKLGHGLR 359


>UniRef50_Q03XZ0 GTP cyclohydrolase II n=1 Tax=Leuconostoc mesenteroides subsp.
           mesenteroides ATCC 8293 RepID=Q03XZ0_LEUMM
          Length = 397

 Score =  235 bits (600), Expect = 7e-61,   Method: Composition-based stats.
 Identities = 85/184 (46%), Positives = 113/184 (61%), Gaps = 2/184 (1%)

Query: 11  LPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQ 70
           LPT +GDF +  F         + L+    S     L R+HSECLTG+   S RC+CG Q
Sbjct: 216 LPTQYGDFHLTEFSVNDEEKSDL-LIQSSRSFDQIPLVRLHSECLTGEIFGSQRCECGPQ 274

Query: 71  LEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDF 130
           L  AL  I ++G G L+Y RQEGR IGL  K+++Y LQ+  +DT +AN  LG   DERD+
Sbjct: 275 LREALKTINKQG-GALVYLRQEGRGIGLHEKLKSYVLQENKFDTYDANVHLGHLPDERDY 333

Query: 131 TLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAEKM 190
              A + K+ G+ ++RLLTNNP KV+ L + GI ++E+VPLI G N  NE Y+ TK EK 
Sbjct: 334 KKAAKILKISGLTKIRLLTNNPDKVQSLIDEGIEVIEQVPLITGINDKNEQYMQTKKEKF 393

Query: 191 GHLL 194
            H L
Sbjct: 394 NHKL 397


>UniRef50_C6QGG9 GTP cyclohydrolase-2 n=1 Tax=Hyphomicrobium denitrificans ATCC
           51888 RepID=C6QGG9_9RHIZ
          Length = 213

 Score =  232 bits (591), Expect = 8e-60,   Method: Composition-based stats.
 Identities = 83/196 (42%), Positives = 113/196 (57%), Gaps = 9/196 (4%)

Query: 8   EAKLPTPW-G---DFLMVGFEELATGHDHVALVYGDIS----GHTPVLARVHSECLTGDA 59
           E  LP  + G         ++        V LV+ D           + R+HS C+TGD 
Sbjct: 18  ETILPIEFQGREITLEAHAYQGETDAEQMVVLVHRDPDVANGSAAIPVVRIHSGCVTGDI 77

Query: 60  LFSLRCDCGFQLEAALTQIAEEGRGILLYH-RQEGRNIGLLNKIRAYALQDQGYDTVEAN 118
             SLRCDC  QL+AAL  I E   G+++Y    EGR IGL  KI+AYALQDQG DTVEAN
Sbjct: 78  FHSLRCDCYQQLQAALKAITEVPLGVIVYAPYHEGRGIGLFKKIQAYALQDQGLDTVEAN 137

Query: 119 HQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPN 178
            ++G   D RD++L A + + LG+ E++LL+NNP K + L   GI + ER+PL++  N  
Sbjct: 138 IEVGAPIDSRDYSLAARVLQDLGMPEIKLLSNNPAKEQALKAHGIRVAERLPLVIKPNKF 197

Query: 179 NEHYLDTKAEKMGHLL 194
           N+ YL+TK  +M H L
Sbjct: 198 NKRYLETKRARMAHKL 213


>UniRef50_Q87D69 GTP cyclohydrolase-2 n=22 Tax=Proteobacteria RepID=RIBA_XYLFT
          Length = 398

 Score =  226 bits (578), Expect = 2e-58,   Method: Composition-based stats.
 Identities = 81/195 (41%), Positives = 108/195 (55%), Gaps = 1/195 (0%)

Query: 2   QLKRVAEAKLPTP-WGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDAL 60
           + + V    +P    G    + F       D VA++ G     + V  RVHS CLTGD  
Sbjct: 172 EYELVTRTPVPLRDLGMSEFIVFRGGIAQRDQVAILIGRPDLSSAVPVRVHSSCLTGDLF 231

Query: 61  FSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQ 120
            SL+CDCG QL  +L  +   G G+LLY  QEGR  G+  KIRAY  Q  G DT++A+ Q
Sbjct: 232 GSLKCDCGDQLRHSLATLKALGGGVLLYLDQEGRGNGIAAKIRAYGYQHVGLDTIDADAQ 291

Query: 121 LGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNE 180
           LGF  DER +T    M + LG+  ++LL+NNP K E L  AGI + +R+ +I      NE
Sbjct: 292 LGFGPDERRYTGAVMMLRALGITRIQLLSNNPAKAERLRAAGIIVKQRISVIGQITKQNE 351

Query: 181 HYLDTKAEKMGHLLN 195
           HYL TK  + GH L+
Sbjct: 352 HYLRTKVSRAGHDLD 366


>UniRef50_C7R1D1 3,4-dihydroxy-2-butanone 4-phosphate synthase n=1 Tax=Jonesia
           denitrificans DSM 20603 RepID=C7R1D1_JONDD
          Length = 411

 Score =  223 bits (570), Expect = 2e-57,   Method: Composition-based stats.
 Identities = 80/191 (41%), Positives = 101/191 (52%), Gaps = 5/191 (2%)

Query: 10  KLPTPWGDFLMVGFEELA---TGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCD 66
            +PTP G   +  +          +H+ L             RVHSECLTGD   S RCD
Sbjct: 221 TMPTPHGSTTVQAWRFTTPRGDVVEHLTLSTWAPDMGVIPDVRVHSECLTGDVFASQRCD 280

Query: 67  CGFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAA 125
           CG QL+ AL  IA    GI++Y R  EGR IGL +KIRAY LQD+GYDTV+AN  LGFA 
Sbjct: 281 CGEQLDRALMHIATH-PGIVVYLRGHEGRGIGLFDKIRAYHLQDEGYDTVDANTALGFAP 339

Query: 126 DERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDT 185
           D+R +   A +   LG + V LLTNNP K   L   G+ +     + +     N  Y+ T
Sbjct: 340 DQRTWEHAAAILTALGASTVNLLTNNPAKQHGLEAHGVTVQGTTRIELPTTIYNADYMRT 399

Query: 186 KAEKMGHLLNK 196
           K  +M H LN 
Sbjct: 400 KKTRMDHQLNN 410


>UniRef50_A5ARE3 Putative uncharacterized protein n=1 Tax=Vitis vinifera
           RepID=A5ARE3_VITVI
          Length = 480

 Score =  222 bits (567), Expect = 4e-57,   Method: Composition-based stats.
 Identities = 67/192 (34%), Positives = 100/192 (52%), Gaps = 40/192 (20%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           ++R A ++LPT WG F    +     G +HVA+V                          
Sbjct: 322 VERTAISRLPTKWGLFQAYCYRSKLDGTEHVAIV-------------------------- 355

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
                          + + GRG+++Y R  EGR IGL +K+RAY LQD+G+DTVEAN +L
Sbjct: 356 -------------KLVEQAGRGVVVYLRGHEGRGIGLGHKLRAYNLQDEGHDTVEANLEL 402

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181
           G A D R++ + A + + +GV  ++L+TNNP K   L   G+ +V RVP++      N+ 
Sbjct: 403 GLAVDAREYGIGAQILRDIGVRTMQLMTNNPAKFTGLKGYGLAVVGRVPVLTPITEENKK 462

Query: 182 YLDTKAEKMGHL 193
           YL+TK  KMGH+
Sbjct: 463 YLETKRTKMGHI 474


>UniRef50_A8FIW0 GTP cyclohydrolase-2 n=7 Tax=Bacillales RepID=A8FIW0_BACP2
          Length = 253

 Score =  221 bits (565), Expect = 7e-57,   Method: Composition-based stats.
 Identities = 76/171 (44%), Positives = 97/171 (56%), Gaps = 1/171 (0%)

Query: 24  EELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQIAEEGR 83
            +LA       LVYGD       L R+HS C TGD   S RCDCGFQL+ ++  I + G 
Sbjct: 71  RQLADHQQSSVLVYGDFEHADEALIRMHSICHTGDIFGSKRCDCGFQLKQSMRMIEDNGA 130

Query: 84  GILLYH-RQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGV 142
           G L Y    EGR IGL  K  AY LQ+ GYDTVEAN  LGF  D R +     + + L  
Sbjct: 131 GALFYLANHEGRGIGLFTKAMAYILQENGYDTVEANEALGFEDDTRQYEEAIAVLQTLRT 190

Query: 143 NEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAEKMGHL 193
             VRL+TNNPKK + ++ AG+++  R+PL    +  NE YL TK  + GH+
Sbjct: 191 KPVRLITNNPKKTDAISHAGLSLSGRIPLWGDVSEFNEKYLQTKINRSGHM 241


>UniRef50_Q4V1U4 GTP cyclohydrolase-2 n=26 Tax=Bacillus cereus group
           RepID=Q4V1U4_BACCZ
          Length = 245

 Score =  220 bits (562), Expect = 2e-56,   Method: Composition-based stats.
 Identities = 79/170 (46%), Positives = 97/170 (57%), Gaps = 1/170 (0%)

Query: 25  ELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQIAEEGRG 84
            LA       LVYGD       L R+HS C TGD   S RCDCGFQL+ +L  I E G G
Sbjct: 69  NLADMQQSSVLVYGDFENSEDALIRMHSICHTGDIFGSKRCDCGFQLKQSLQMITEHGSG 128

Query: 85  ILLYH-RQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVN 143
            L Y    EGR IGL +K   Y LQ+ G DTVEAN  LGF  D R++    ++ K L   
Sbjct: 129 ALFYLANHEGRGIGLFSKAMTYLLQENGLDTVEANLNLGFEDDVRNYDDTIEVLKALRSK 188

Query: 144 EVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAEKMGHL 193
            V+L+TNNPKK+E L +AG+N+  R PL    +  NE YL TK ++ GH 
Sbjct: 189 PVKLITNNPKKLEALQKAGLNVTSREPLWGDVSEFNEKYLQTKIQRSGHF 238


>UniRef50_Q3YT81 GTP cyclohydrolase-2 n=6 Tax=canis group RepID=Q3YT81_EHRCJ
          Length = 380

 Score =  220 bits (561), Expect = 2e-56,   Method: Composition-based stats.
 Identities = 71/176 (40%), Positives = 105/176 (59%), Gaps = 2/176 (1%)

Query: 19  LMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQI 78
            +  +       DH A++ G+     P+  R+HS C TGD L SL CDC  QL  A+  +
Sbjct: 191 KIKVYRSYTGELDHYAIIIGNPDYSNPI-VRIHSSCYTGDLLNSLSCDCRCQLHTAIKLM 249

Query: 79  AEEGRGILLYHRQEGRNIGLLNKIRAYALQ-DQGYDTVEANHQLGFAADERDFTLCADMF 137
            E   GI+LY  Q+GR IGL NKIR Y LQ    +DTV+AN   GF  DER FT    + 
Sbjct: 250 TENKGGIILYLAQDGRGIGLANKIRTYQLQTKHNFDTVDANRFFGFEDDERVFTPAIKIL 309

Query: 138 KLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAEKMGHL 193
           + LG++ ++LLTNNP K+  + +  I + + +P+ V  N +N +Y++TKA+++GH+
Sbjct: 310 QKLGISRLQLLTNNPNKISEIQKNNIQVTKILPIFVDTNQHNINYINTKAKRLGHV 365


>UniRef50_P51618 GTP cyclohydrolase-2 n=63 Tax=Gammaproteobacteria RepID=RIBA_PHOPO
          Length = 200

 Score =  220 bits (560), Expect = 2e-56,   Method: Composition-based stats.
 Identities = 87/178 (48%), Positives = 110/178 (61%), Gaps = 2/178 (1%)

Query: 19  LMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQI 78
            ++ F  L +G +H+AL++ D       L R+HSECLTGD   S RCDCG QL+  +  +
Sbjct: 21  ELLSFNGLESGKEHIALIFKDAYKAFVPLVRMHSECLTGDGFHSTRCDCGEQLDETIEIM 80

Query: 79  AEEGRGILLYHRQEGR-NIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMF 137
           AE G GI+LY RQEGR  +GL NKI AY LQ QG DT EAN+ LGF  D R+F+  A M 
Sbjct: 81  AELG-GIILYLRQEGRWGLGLYNKIDAYKLQSQGMDTYEANNHLGFDDDLREFSEAAQML 139

Query: 138 KLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAEKMGHLLN 195
             LG+ ++RL+TNNPKK++ L + GINIVE V         NE YL  KA    H  N
Sbjct: 140 TALGIKDIRLVTNNPKKIKDLQQNGINIVEVVGTKAHLKEGNEGYLKAKASHGRHCFN 197


>UniRef50_C5AMM6 GTP cyclohydrolase-2 n=2 Tax=Burkholderia glumae RepID=C5AMM6_BURGB
          Length = 252

 Score =  219 bits (559), Expect = 3e-56,   Method: Composition-based stats.
 Identities = 87/177 (49%), Positives = 101/177 (57%), Gaps = 4/177 (2%)

Query: 19  LMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQI 78
            MV F  L    +H+ALV+G I      L R+HSECLTGD   S RCDCG QL+ ++   
Sbjct: 72  EMVTFNGLCDSAEHIALVFGKI--GEAPLVRLHSECLTGDVFGSARCDCGEQLDESIALF 129

Query: 79  AEEGRGILLYHRQEGRNIGLLNKIRAYALQ-DQGYDTVEANHQLGFAADERDFTLCADMF 137
            E G GILLY RQEGR IGL NK+ AY LQ  QG DT  AN  L F  D RDF + A M 
Sbjct: 130 GERG-GILLYLRQEGRGIGLYNKLDAYRLQISQGLDTFAANRALNFPDDLRDFRVAAQML 188

Query: 138 KLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAEKMGHLL 194
           K LGV EV L+TNNP K   LT  GI + +     V  N  N  YL  KA +  H +
Sbjct: 189 KALGVGEVSLVTNNPDKTAQLTRHGIKVRQVKSTGVFANSVNFGYLHAKATQHRHAI 245


>UniRef50_B9KHB1 GTP cyclohydrolase-2 n=5 Tax=Anaplasma RepID=B9KHB1_ANAMF
          Length = 377

 Score =  218 bits (557), Expect = 6e-56,   Method: Composition-based stats.
 Identities = 74/176 (42%), Positives = 103/176 (58%), Gaps = 2/176 (1%)

Query: 19  LMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQI 78
            ++ +       +H A++ GD S   PV  R+HS C TGD L S+ CDC  QL   +  +
Sbjct: 202 KILVYRSNLGEPEHYAIIIGDPSFENPV-VRLHSSCYTGDLLGSISCDCRGQLLHTIQFL 260

Query: 79  AEEGRGILLYHRQEGRNIGLLNKIRAYALQDQG-YDTVEANHQLGFAADERDFTLCADMF 137
                GI+LY  QEGR IGL NKIRAY LQ Q   DTV+AN  LGF  DER F   A + 
Sbjct: 261 GSGSGGIVLYISQEGRGIGLANKIRAYNLQTQNALDTVDANRFLGFDDDERVFLPAARIL 320

Query: 138 KLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAEKMGHL 193
             LG+++ ++LT+NP KV  + + G  + + +PL VG +  N  Y+ TK E++GH+
Sbjct: 321 DELGISKFQMLTSNPSKVSSMCDHGFTVTKMIPLSVGTHERNIDYIKTKIERLGHV 376


>UniRef50_C9S9H3 GTP cyclohydrolase-2 n=1 Tax=Verticillium albo-atrum VaMs.102
           RepID=C9S9H3_VERA1
          Length = 379

 Score =  216 bits (551), Expect = 3e-55,   Method: Composition-based stats.
 Identities = 74/171 (43%), Positives = 97/171 (56%), Gaps = 13/171 (7%)

Query: 39  DISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQIA---EEGRGILLYHRQEGRN 95
             +   P L R+HSEC TG+  +S RCDCG QL+ A   ++       GI++Y RQEGR 
Sbjct: 204 PPAPTGPPLVRIHSECYTGETAWSARCDCGEQLDEAARLMSLPGNHNGGIIIYLRQEGRG 263

Query: 96  IGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKV 155
           IGL  K++AY LQD G DTVEAN  L   AD R + L   M   LG +EVRLLTNNP K+
Sbjct: 264 IGLGEKLKAYNLQDLGSDTVEANLLLRHPADARSYGLATAMLLDLGQDEVRLLTNNPDKI 323

Query: 156 EILTEAG--INIVERVPLI--------VGRNPNNEHYLDTKAEKMGHLLNK 196
             +      + + ERV ++          ++   E YL TK EKMGH+L+ 
Sbjct: 324 RAVEGPNREVRVRERVAMVPLSWKGKGGFKSEEVEGYLKTKIEKMGHMLDS 374


>UniRef50_A8NX34 GTP cyclohydrolase-2 n=2 Tax=Agaricales RepID=A8NX34_COPC7
          Length = 468

 Score =  215 bits (549), Expect = 5e-55,   Method: Composition-based stats.
 Identities = 95/296 (32%), Positives = 127/296 (42%), Gaps = 102/296 (34%)

Query: 1   MQLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALV------------------------ 36
           +Q+K +A  ++PTP G   +  +       +H+A+V                        
Sbjct: 162 LQVKCMARTRIPTPHGPAFLHLYHNNRDNKEHLAIVVDPSQLDQSAPSLPPIRSRSLDSV 221

Query: 37  --------------------------YGDISGHTP---------VLARVHSECLTGDALF 61
                                       D S +TP          L R+HSEC TG+ + 
Sbjct: 222 WSENETEMDRIIRGAYVGRLSPTYQKASDPSINTPQSTPSDLPPPLIRIHSECFTGETVG 281

Query: 62  SLRCDCGFQLEAALTQIAE------EGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTV 115
           S+RCDCG QL+ A+ QI+        GRG ++Y RQEGR IGLL+KIRAY LQD G+DTV
Sbjct: 282 SMRCDCGEQLDEAIRQISNPINSQIPGRGAVIYLRQEGRGIGLLSKIRAYNLQDMGHDTV 341

Query: 116 EANHQLGFAADERDFTLCADMFKLLGVN---------EVRLLTNNPKKVEILTEAGINIV 166
            AN  LG  ADER + +   + K LG+           VR+LTNNP K+E L + GI I 
Sbjct: 342 TANLMLGHKADERGYEIAGAILKDLGLGCGENASCSESVRILTNNPDKMEALRKEGIQIS 401

Query: 167 ERVPLIVGR------NPNNE----------------------HYLDTKAEKMGHLL 194
           ERVP+I                                     YL TK  +MGH+L
Sbjct: 402 ERVPMIPRSWQQRSQTEETVVKQETLGLTLIGGKAVHGDDLDKYLRTKVVRMGHML 457


>UniRef50_B0UFT4 GTP cyclohydrolase-2 n=4 Tax=Rhizobiales RepID=B0UFT4_METS4
          Length = 370

 Score =  214 bits (546), Expect = 1e-54,   Method: Composition-based stats.
 Identities = 87/194 (44%), Positives = 108/194 (55%), Gaps = 1/194 (0%)

Query: 3   LKRVAEAKLPTPWG-DFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALF 61
           L+ V+ A +P     +   V F       D VA+V G      PV  RVHS CLTGD   
Sbjct: 165 LQIVSRAPVPLDGAPETEFVVFRGGEGLRDQVAVVIGRPDPAQPVAVRVHSACLTGDLFG 224

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
           SL+CDCG QL      +A+ G GI+LY  QEGR  GL NKIRAYALQ +GYDT  A+  L
Sbjct: 225 SLKCDCGDQLRGTAKWMAQNGGGIILYLDQEGRGNGLANKIRAYALQAKGYDTYAADEML 284

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181
           GF  D+R F   A M + LGV  VR+L+NNP+KV  L  AG+ +V     +    P N  
Sbjct: 285 GFGLDQRRFDFAAAMLRCLGVASVRVLSNNPEKVAALAAAGLAVVGEQRALGRVTPENAR 344

Query: 182 YLDTKAEKMGHLLN 195
           YL  K +  GH L+
Sbjct: 345 YLAAKRDVAGHALD 358


>UniRef50_Q14FW6 Riboflavin biosynthesis protein ribA/GTP-cyclohydrolase II n=20
           Tax=Proteobacteria RepID=Q14FW6_FRAT1
          Length = 403

 Score =  213 bits (544), Expect = 2e-54,   Method: Composition-based stats.
 Identities = 74/196 (37%), Positives = 105/196 (53%), Gaps = 10/196 (5%)

Query: 3   LKRVAEAKLP-TPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALF 61
           + ++A + +P    G+  M  +++  +G + V L           L R+HS C+TGD   
Sbjct: 211 VTKMASSTIPFKKIGELEMSVYKDNFSGDEVVVLSK--PYSGNNPLVRMHSSCITGDIFG 268

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQ-DQGYDTVEANHQ 120
           SLRCDC  QL   +  I+EEG G  +Y  QEGR IGL NK++AY LQ ++  DT+EAN  
Sbjct: 269 SLRCDCQDQLHKGIEMISEEG-GFFIYLDQEGRGIGLTNKLKAYNLQMNENMDTLEANLA 327

Query: 121 LGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGR--NPN 178
           LG  AD R + L   + K   VN  RL++NNP+K+  L    I   E  P+      N +
Sbjct: 328 LGLPADARKYDLAIQVLKYNNVNRCRLISNNPEKLAALRNVDI---ETQPVYCEAFVNSH 384

Query: 179 NEHYLDTKAEKMGHLL 194
           N +YL TK  K  H +
Sbjct: 385 NRNYLITKKIKAKHTI 400


>UniRef50_P50139 GTP cyclohydrolase-2 n=33 Tax=Ascomycota RepID=RIB1_PICGU
          Length = 332

 Score =  212 bits (541), Expect = 4e-54,   Method: Composition-based stats.
 Identities = 75/166 (45%), Positives = 99/166 (59%), Gaps = 10/166 (6%)

Query: 41  SGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLN 100
               P+LAR+HSEC TG+  +S RCDCG Q + A   + E G G ++Y RQEGR IGL  
Sbjct: 163 CSGEPILARIHSECYTGETAWSARCDCGEQFDEAGRLMGEAGHGCIVYLRQEGRGIGLGE 222

Query: 101 KIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTE 160
           K++AY LQD G DTV+AN  L   AD R F+L   +   LG+NE++LLTNNP K+  +  
Sbjct: 223 KLKAYNLQDLGADTVQANLMLRHPADARSFSLATAILLDLGLNEIKLLTNNPDKIAAVEG 282

Query: 161 AG--INIVERVPLIVGR--------NPNNEHYLDTKAEKMGHLLNK 196
               + +VERVP++           +   E YL  K E+MGHLL K
Sbjct: 283 RNREVKVVERVPMVPLAWRSENGIKSKEIEGYLSAKIERMGHLLEK 328


>UniRef50_P38066 GTP cyclohydrolase-2 n=8 Tax=Saccharomycetales RepID=RIB1_YEAST
          Length = 345

 Score =  208 bits (529), Expect = 1e-52,   Method: Composition-based stats.
 Identities = 77/187 (41%), Positives = 102/187 (54%), Gaps = 21/187 (11%)

Query: 31  DHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQIAE---------- 80
           + +A        H   L R+HSEC TG+  +S RCDCG Q + A   IA           
Sbjct: 125 ELLASKATTWDAHNDTLVRIHSECYTGENAWSARCDCGEQFDRAGRLIACDHEPTSNIKG 184

Query: 81  -EGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKL 139
             G G+++Y RQEGR IGL  K++AY LQD G DTV+AN  L    D RDF+L   +   
Sbjct: 185 GNGHGVIVYLRQEGRGIGLGEKLKAYNLQDLGADTVQANLMLKHPVDARDFSLGKAILLD 244

Query: 140 LGVNEVRLLTNNPKKVEILTEAG-INIVERVPLIVGR---------NPNNEHYLDTKAEK 189
           LG+  VRLLTNNP+K++ +  A  +  VERVP++            +   E YL TK E+
Sbjct: 245 LGIGNVRLLTNNPEKIKQVDHAPYLKCVERVPMVPIHWTNSSEGIDSKEIEGYLRTKIER 304

Query: 190 MGHLLNK 196
           MGHLL +
Sbjct: 305 MGHLLTE 311


>UniRef50_B8KSW9 GTP cyclohydrolase-2 n=1 Tax=gamma proteobacterium NOR51-B
           RepID=B8KSW9_9GAMM
          Length = 273

 Score =  207 bits (528), Expect = 1e-52,   Method: Composition-based stats.
 Identities = 74/166 (44%), Positives = 95/166 (57%), Gaps = 4/166 (2%)

Query: 34  ALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQIA-EEGRGILLYHR-Q 91
            LV G+       L RVHS CLTGD   S RC+CG QLEAA+ +IA +E  G L+Y    
Sbjct: 103 VLVIGEPEKSEAPLVRVHSSCLTGDVFGSRRCECGPQLEAAIDRIATDEQGGYLIYMAGH 162

Query: 92  EGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGV-NEVRLLTN 150
           EGR IGL  K   Y LQD G DT +AN  LG   D RDF+  A +    G   ++RL+TN
Sbjct: 163 EGRGIGLWAKAATYLLQDAGEDTYQANRSLGLPDDSRDFSDAATLLHYFGAGRKLRLMTN 222

Query: 151 NPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAEKMGHLLNK 196
           NPKK+E L   G+  +ERV  + G +  N  YL  K  + GH +++
Sbjct: 223 NPKKIEDLRAFGVPNLERVKHVSGVDDCNLRYLQAKR-QWGHRIDE 267


>UniRef50_A6MYZ0 GTP cyclohydrolase-2 n=2 Tax=Saccharomycetaceae RepID=A6MYZ0_9SACH
          Length = 313

 Score =  205 bits (521), Expect = 9e-52,   Method: Composition-based stats.
 Identities = 77/173 (44%), Positives = 99/173 (57%), Gaps = 16/173 (9%)

Query: 39  DISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGL 98
           D  G T  L R+HSEC TG+  +S RCDCG Q + A   I E G G+++Y RQEGR IGL
Sbjct: 108 DEDGDTGTLVRLHSECYTGETAWSARCDCGEQFDRAGRMIGESGSGVIVYLRQEGRGIGL 167

Query: 99  LNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEIL 158
             K++AY LQD G DTV+AN  L    D RDF+L   +   LG+  VRLLTNNP+K++ +
Sbjct: 168 GEKLKAYNLQDLGADTVQANLLLKHPVDGRDFSLGRAILVDLGIKSVRLLTNNPQKLQQV 227

Query: 159 -TEAGINIVERVPLI---------------VGRNPNNEHYLDTKAEKMGHLLN 195
                +  VERVP+I                 R+   + YL  K E+MGHLL 
Sbjct: 228 HCPPLLTCVERVPMIPLSWIDGVREAGXEVGIRSKEVDAYLRVKMEQMGHLLQ 280


>UniRef50_A0Z3E0 GTP cyclohydrolase-2 n=1 Tax=marine gamma proteobacterium HTCC2080
           RepID=A0Z3E0_9GAMM
          Length = 272

 Score =  204 bits (520), Expect = 1e-51,   Method: Composition-based stats.
 Identities = 76/166 (45%), Positives = 96/166 (57%), Gaps = 4/166 (2%)

Query: 34  ALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQIAEE-GRGILLYHR-Q 91
            L  GD       L RVHS CLTGD   S RC+CG QLEAA+ ++AEE G G L+Y    
Sbjct: 103 VLAIGDAETTESPLVRVHSNCLTGDVFGSRRCECGPQLEAAIDRLAEEPGGGYLIYMAGH 162

Query: 92  EGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNE-VRLLTN 150
           EGR IGL  K   Y LQD+G DT +AN  LG   D RDF+  A + K  G    +RLLTN
Sbjct: 163 EGRGIGLWAKAATYLLQDEGEDTYQANRSLGLPDDSRDFSDAATLLKYFGRGRPLRLLTN 222

Query: 151 NPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAEKMGHLLNK 196
           NPKK++ L   G+  +ERV  + G + +N  YL  K    GH +++
Sbjct: 223 NPKKIDDLLANGLTNIERVKHVTGVDDHNLRYLKAKQA-WGHSIDE 267


>UniRef50_C9PF77 GTP cyclohydrolase II n=1 Tax=Vibrio furnissii CIP 102972
           RepID=C9PF77_VIBFU
          Length = 352

 Score =  203 bits (516), Expect = 4e-51,   Method: Composition-based stats.
 Identities = 69/189 (36%), Positives = 101/189 (53%), Gaps = 9/189 (4%)

Query: 9   AKLPTPWGDFLMVGFEELATGHDHV-ALVYGDISG-HTPVLARVHSECLTGDALFSLRCD 66
            +LPT  G F M       TG++    + +GDIS   +  + R+HS CL  +   +  CD
Sbjct: 7   CELPTLHGTFRMY-----DTGNELFRVVTFGDISNLGSQPMVRIHSSCLASEVFEARDCD 61

Query: 67  CGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRA-YALQDQGYDTVEANHQLGFAA 125
           C  QL  A+  +A +G GI+ +  QEGR  GL  KI+A Y +Q +  DT E+   +G   
Sbjct: 62  CADQLREAMKAMAHDGSGIIFHLHQEGRGQGLSKKIQAVYKMQVEALDTAESFQAMGLEQ 121

Query: 126 DERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDT 185
           D RD+     + K + + EVRL++NNP+K   L +AGI + E V       P N  YL +
Sbjct: 122 DIRDYEPAISVLKKMAIEEVRLVSNNPRKRSALEQAGIAV-EVVNTHPQVRPENAGYLQS 180

Query: 186 KAEKMGHLL 194
           K +K+GH L
Sbjct: 181 KNDKLGHYL 189


>UniRef50_A8FAX3 GTP cyclohydrolase-2 n=2 Tax=Bacillus pumilus RepID=A8FAX3_BACP2
          Length = 241

 Score =  202 bits (514), Expect = 6e-51,   Method: Composition-based stats.
 Identities = 66/164 (40%), Positives = 95/164 (57%), Gaps = 4/164 (2%)

Query: 35  LVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQIAEEGRGILLYH-RQEG 93
           L++GD     P L R+HS C TGD   SL+CDCG QL  +L +I + G+G+L+Y   QEG
Sbjct: 74  LLFGDFENEMPPLVRIHSVCQTGDVFGSLKCDCGPQLALSLKKITDYGKGMLVYMANQEG 133

Query: 94  RNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNE-VRLLTNNP 152
           R+IGL+ K   Y LQ+   DT EAN  +G   D+R +   A +   L   + + LLTNNP
Sbjct: 134 RSIGLMAKALTYKLQEMQLDTFEANRLIGCGDDDRHYEEAAAVLHYLNKGKPMHLLTNNP 193

Query: 153 KKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAEKMGHLLNK 196
            KV+ +   G+ ++ R    V  +  NE YL  KA   GH++++
Sbjct: 194 DKVDSIAAYGLPVL-RFDHTVEASLYNEAYLKAKAA-SGHMVDE 235


>UniRef50_C5LSF0 GTP cyclohydrolase II, putative (Fragment) n=1 Tax=Perkinsus
           marinus ATCC 50983 RepID=C5LSF0_9ALVE
          Length = 406

 Score =  200 bits (510), Expect = 2e-50,   Method: Composition-based stats.
 Identities = 77/196 (39%), Positives = 108/196 (55%), Gaps = 10/196 (5%)

Query: 5   RVAEAKLPTPWGDFL----MVGFEELAT-GHDHVALVYGDISGHTPVLARVHSECLTGDA 59
           +++  ++P     +     +  +   +    + V L+ G + G + V  R+HSEC TGD 
Sbjct: 211 QLSSCRVPLHHLRYTSHCDLRVYRGCSDPSLELVTLIKGKVEGESNVPVRIHSECFTGDV 270

Query: 60  LFSLRCDCGFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQ-GYDTVEA 117
           L S++CDCG QL   L  + EE R +LLY R  EGR IGL NK++AY LQD+ G DT+E+
Sbjct: 271 LRSMKCDCGDQLLDFLVTLDEEERAVLLYIRGHEGRGIGLANKVKAYNLQDEDGLDTIES 330

Query: 118 NHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNP 177
           N +LG+A D RDF       + LG++ V L TNNP KV  L +    + E   +    N 
Sbjct: 331 NIRLGYAPDCRDFADARRALRHLGIHSVMLYTNNPAKVAALGDM---VAEVKAVPARPNR 387

Query: 178 NNEHYLDTKAEKMGHL 193
           NN  YL TK  K  HL
Sbjct: 388 NNIGYLRTKQSKFHHL 403


>UniRef50_C0A9J6 GTP cyclohydrolase-2 n=1 Tax=Opitutaceae bacterium TAV2
           RepID=C0A9J6_9BACT
          Length = 516

 Score =  200 bits (510), Expect = 2e-50,   Method: Composition-based stats.
 Identities = 74/195 (37%), Positives = 99/195 (50%), Gaps = 5/195 (2%)

Query: 6   VAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRC 65
           +A   L T +G F    F+++   H  +AL +GDI G T +  R+HS C+T + L    C
Sbjct: 40  LATCALDTRYGAFRAYVFQDITDKHYILALTHGDICGATTLHTRLHSSCVTSETLRGCDC 99

Query: 66  DCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYD---TVEANHQLG 122
           DC  QLE A   IA++G GIL Y  QEGR +G   K R   L     D   T +A   +G
Sbjct: 100 DCTQQLEGAFKVIAQKGSGILFYLMQEGRGVGYFAKARDRMLVQASQDQLSTFDAYAAMG 159

Query: 123 FAADERDFTLCADMFKLLGVN-EVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181
            A D R++   + +  LLG+     LLTNNP K+E L   G+ I    PL     P N  
Sbjct: 160 LAKDHRNYENISHICHLLGIRASFILLTNNPDKIEALRAQGLPIAGSEPLEFEPGPFNLA 219

Query: 182 YLDTKAEKMGHLLNK 196
           YL +KA   GH L +
Sbjct: 220 YLTSKAAN-GHQLQR 233



 Score = 85.2 bits (210), Expect = 1e-15,   Method: Composition-based stats.
 Identities = 35/167 (20%), Positives = 67/167 (40%), Gaps = 12/167 (7%)

Query: 9   AKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCG 68
           A L TP+  F +  + ++ T  D V L +G  +     + R+HS+ +          D  
Sbjct: 340 ALLTTPY-WFRVHAYYDIVTNQDWVVLTHGTPTPDDAPVVRLHSDSIFN-RFPLRTTDNR 397

Query: 69  FQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTV--EANHQLGFAAD 126
            +L+ A+  I   G G++L    +GR  G         + + G  +   +A   L    D
Sbjct: 398 AKLKQAVKHIVTYGSGVMLLLHNDGRGAGFGAHATDRMMTEAGAVSTSDDAYRLLAVGYD 457

Query: 127 ERDFTLCADMF-KLLGVNEVRLLTNNPKKV-------EILTEAGINI 165
            RD+     +    L    ++++ N+P+ +       E L    I++
Sbjct: 458 SRDYDAAIMLLRHHLPSERIQMVMNSPESLVKKPEYAEALNRHHIDV 504


>UniRef50_Q5KNS2 GTP cyclohydrolase-2 n=1 Tax=Filobasidiella neoformans
           RepID=Q5KNS2_CRYNE
          Length = 550

 Score =  200 bits (509), Expect = 3e-50,   Method: Composition-based stats.
 Identities = 86/259 (33%), Positives = 118/259 (45%), Gaps = 88/259 (33%)

Query: 19  LMVGFEELATGHDHVALVYGDISG-----HTPVLARVHSECLTGDALFSLRCDCGFQLEA 73
            +     ++ G +H      + SG         L R+HSEC TG+ + S+RCDCG QL+ 
Sbjct: 293 RLKAGATVSNGGEH------EPSGIVGVQDIKPLVRIHSECFTGETIGSMRCDCGEQLDE 346

Query: 74  ALTQIAEE-----------------------------------GRGILLYHRQEGRNIGL 98
           A+ QIAE                                    GRG+++Y RQEGR IGL
Sbjct: 347 AIHQIAEPQRIPVPLVAPNSYSGDSFSTSAAFHPETTAYTHVPGRGVVIYLRQEGRGIGL 406

Query: 99  LNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNE--VRLLTNNPKKVE 156
           L KIRAY LQD G+DTV AN  LG  ADER + + A++ + LG+ +  +RLLTNNP+KV 
Sbjct: 407 LEKIRAYNLQDLGHDTVTANLMLGHGADERKYDIAAEILRDLGLADEGIRLLTNNPEKVR 466

Query: 157 ILTEAGINIVERVPLI----------------------------------------VGRN 176
            L   G+ +VERV +                                         +   
Sbjct: 467 GLAREGVKVVERVGMTPRSWQCGDDHSHENKDGAKEEKEYEDWRMRRAGVGLIGAGMASG 526

Query: 177 PNNEHYLDTKAEKMGHLLN 195
           P  E YL TK E+MGH+++
Sbjct: 527 PELEKYLRTKVERMGHIID 545



 Score = 41.7 bits (97), Expect = 0.013,   Method: Composition-based stats.
 Identities = 9/46 (19%), Positives = 23/46 (50%)

Query: 1   MQLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPV 46
           +Q++ +A  ++P+P G+  +  +       +H+A++   I     V
Sbjct: 210 IQVRCMARTRIPSPHGELFLHLYHNSYDAKEHLAILLDPIQLDAEV 255


>UniRef50_Q4P4Y7 GTP cyclohydrolase-2 n=2 Tax=Basidiomycota RepID=Q4P4Y7_USTMA
          Length = 776

 Score =  198 bits (503), Expect = 1e-49,   Method: Composition-based stats.
 Identities = 67/146 (45%), Positives = 90/146 (61%), Gaps = 16/146 (10%)

Query: 46  VLARVHSECLTGDALFSLRCDCGFQLEAALTQIAEE----------------GRGILLYH 89
            L R+HSEC TG+ + S RCDCG QL+ A+  I+E                 GRG+++Y 
Sbjct: 451 PLVRIHSECFTGETIGSQRCDCGEQLDEAIRLISEAYDTSKPRDPGAAQQKLGRGVIVYL 510

Query: 90  RQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNEVRLLT 149
           RQEGR IGLL+K+ AY LQD G+DTV AN  LG   D R + + + + K LGV+E RLLT
Sbjct: 511 RQEGRGIGLLDKLMAYNLQDMGHDTVSANILLGHLPDARKYDIASAILKDLGVDECRLLT 570

Query: 150 NNPKKVEILTEAGINIVERVPLIVGR 175
           NNP+K+E L   G+ + ERV ++   
Sbjct: 571 NNPEKMEALEAEGVRVAERVGMVPRV 596



 Score = 41.3 bits (96), Expect = 0.017,   Method: Composition-based stats.
 Identities = 10/50 (20%), Positives = 24/50 (48%), Gaps = 1/50 (2%)

Query: 1   MQLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARV 50
           ++++  A  ++PTP G+     ++      +H+A+V  D   +     R+
Sbjct: 327 VRVRCYARTRVPTPHGEVFCHLYKNTHDTKEHLAIVI-DPYQNDEASTRM 375


>UniRef50_D0L7U8 3,4-dihydroxy-2-butanone 4-phosphate synthase n=1 Tax=Gordonia
           bronchialis DSM 43247 RepID=D0L7U8_GORB4
          Length = 418

 Score =  197 bits (502), Expect = 1e-49,   Method: Composition-based stats.
 Identities = 71/203 (34%), Positives = 105/203 (51%), Gaps = 13/203 (6%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPV----LARVHSECLTGD 58
           + +VA A +PT +GDF  V +     G +H+AL+ GD++  +      L RVHSECLTGD
Sbjct: 215 VAQVASAAMPTAFGDFRAVAYRCELDGTEHLALLMGDLAAASRTDRGALVRVHSECLTGD 274

Query: 59  ALFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEAN 118
            L SLRCDCG QLE AL+ IAEEG G ++Y R   R  G + + R+   + +   +  + 
Sbjct: 275 ILGSLRCDCGSQLEQALSAIAEEGCGAVVYLRGM-RAAGSVWRTRSAPTRCRNRVSTPST 333

Query: 119 HQLGFAADERDFTLCADMFKLLG--VNEVRLLTNNP---KKVEILTEAGINIVERVPLIV 173
               +      +   A ++ L     +E     ++P   +K   L    + IV R  L  
Sbjct: 334 PTPRWGC---RWIPAATVWVLRSSPTSEPGGSASSPTTRQKYGGLEGFDLEIVGRFGLPT 390

Query: 174 GRNPNNEHYLDTKAEKMGHLLNK 196
              P+N  YL TK E+MGH L++
Sbjct: 391 VITPHNVRYLRTKQERMGHTLDQ 413


>UniRef50_Q2S6L1 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
           n=5 Tax=Bacteria RepID=Q2S6L1_SALRD
          Length = 415

 Score =  195 bits (496), Expect = 8e-49,   Method: Composition-based stats.
 Identities = 66/186 (35%), Positives = 99/186 (53%), Gaps = 10/186 (5%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           ++R AE  L T +G F +V +EE  TG  H+AL+ GD +   PVL RVHS+ + GD L +
Sbjct: 219 IERAAEVDLDTAFGTFQVVAYEETLTGDVHLALLKGDWAEDEPVLVRVHSQNVLGDVLAA 278

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIR---AYALQDQGYDTVEANH 119
            R     +L  AL Q+  EG G +LY  Q     GLL+K++    +  QD G  T     
Sbjct: 279 RRESYSEELAEALLQVEHEGTGAILYMMQSNHGQGLLSKLKDLERHQNQDDGAPT----- 333

Query: 120 QLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNN 179
            +    D RD+ +   + + LG+ ++RLLTNNP+K   L   G+ +VE+ P+ +      
Sbjct: 334 DVSLEMDHRDYGIGCQILRDLGIRKLRLLTNNPRKRIGLAGYGLELVEQTPIELP--TEA 391

Query: 180 EHYLDT 185
             +L T
Sbjct: 392 RDHLST 397


>UniRef50_A1SF04 GTP cyclohydrolase-2 n=16 Tax=Bacteria RepID=A1SF04_NOCSJ
          Length = 215

 Score =  193 bits (490), Expect = 3e-48,   Method: Composition-based stats.
 Identities = 74/174 (42%), Positives = 95/174 (54%), Gaps = 5/174 (2%)

Query: 19  LMVGFEELATGHDHVALVYGD---ISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAAL 75
            +  F  L    +H+ +  G      G  P L R+HSECLTGD   S RCDCG QL+ AL
Sbjct: 30  RVHTFTGLPGAEEHLVVAVGPYRRPRGGVP-LVRLHSECLTGDVFGSRRCDCGPQLDEAL 88

Query: 76  TQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCAD 135
            +IAE G G L+Y RQEGR IGL  K+ AY LQDQG DT EAN  LG+  D R + +   
Sbjct: 89  VRIAEHG-GYLVYLRQEGRGIGLYAKLDAYRLQDQGLDTFEANRALGYPEDARGYEVAGR 147

Query: 136 MFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAEK 189
           M + L V +V L+T NP+K   L   G+ +   +P  +     N  YL  K  +
Sbjct: 148 MLRALDVLQVDLMTGNPQKAAGLAAGGVAVRRTLPTALHETTENLRYLHAKRRR 201


>UniRef50_A0SNY3 Riboflavin biosynthesis protein RibA n=2 Tax=Candidatus
           Micrarchaeum acidiphilum ARMAN-2 RepID=A0SNY3_9EURY
          Length = 290

 Score =  183 bits (464), Expect = 4e-45,   Method: Composition-based stats.
 Identities = 63/215 (29%), Positives = 102/215 (47%), Gaps = 20/215 (9%)

Query: 1   MQLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISG-------HTPVLARVHSE 53
           +Q+ R+    + TP+G F    FE      ++  LV   +            +L R+ S 
Sbjct: 74  VQVTRLGLGPIDTPFGKFYEFEFEVGDRWKEYNVLVKAGLDDKFNPQFEDGKILVRMDSA 133

Query: 54  CLTGDALFSLRCDCGFQLEAALTQIAEEGRGILLYH-RQEGRNIGLLNKIRAYALQDQ-G 111
           C TG       CDC  QL  A+ +I + G G++++  +Q+GR +GL  K+    LQD+ G
Sbjct: 134 CKTGQLFHDKTCDCKLQLLKAMHEIEKNGSGMIVHMPKQDGRGMGLSFKLGTLMLQDELG 193

Query: 112 YDTVEANHQLGF-------AADERDFTLCADMFKLLGVNE---VRLLTNNPKKVEILTEA 161
           Y+TVEA   L         A D R +     + +  G++    + + TNNPKK++   E 
Sbjct: 194 YNTVEAAAALKSMEFIEPEALDPRTYGGVIAILRFFGIDSGFDINVATNNPKKIQAFQEN 253

Query: 162 GINIVERVPLIVGRNPNNEHYLDTKAEKMGHLLNK 196
           G ++  R P+I+  N   + +LD K E   H L +
Sbjct: 254 GYDV-GRTPVIIPPNEYTKRHLDAKEETFHHDLRR 287


>UniRef50_A8PZB1 GTP cyclohydrolase-2 n=1 Tax=Malassezia globosa CBS 7966
           RepID=A8PZB1_MALGO
          Length = 455

 Score =  181 bits (461), Expect = 8e-45,   Method: Composition-based stats.
 Identities = 62/144 (43%), Positives = 83/144 (57%), Gaps = 11/144 (7%)

Query: 46  VLARVHSECLTGDALFSLRCDCGFQLEAALTQIAEEGRGILL-----------YHRQEGR 94
            L R+HSEC TG+ + S RCDCG QL+ AL  I                    Y RQEGR
Sbjct: 167 PLVRIHSECYTGETIGSQRCDCGEQLDEALRIIGTSSSRTATGVPVPPRGVVVYMRQEGR 226

Query: 95  NIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKK 154
            IGLL+K+ AY LQD G+DTV AN  LG   D R + + + + + LG+++ RLLTNNP+K
Sbjct: 227 GIGLLDKLLAYNLQDMGHDTVSANVLLGHLPDARRYDISSAILRDLGIDQCRLLTNNPEK 286

Query: 155 VEILTEAGINIVERVPLIVGRNPN 178
           ++ L   GI + ERVP++      
Sbjct: 287 MQALEAEGIRVTERVPMVPRIWQF 310



 Score = 39.4 bits (91), Expect = 0.076,   Method: Composition-based stats.
 Identities = 8/37 (21%), Positives = 18/37 (48%)

Query: 1  MQLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVY 37
          ++++     ++PTP G+     +       +H+ALV 
Sbjct: 53 LEVRCYGRTRVPTPHGEVFCHLYRNNHDNKEHMALVI 89


>UniRef50_Q0D0K3 GTP cyclohydrolase-2 n=29 Tax=Leotiomyceta RepID=Q0D0K3_ASPTN
          Length = 447

 Score =  181 bits (459), Expect = 1e-44,   Method: Composition-based stats.
 Identities = 66/184 (35%), Positives = 85/184 (46%), Gaps = 37/184 (20%)

Query: 42  GHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQIA-------------------EEG 82
                L R+HSEC TG+  +S RCDCG QL+ A   ++                      
Sbjct: 226 PSQAPLVRIHSECYTGETAWSARCDCGEQLDEAARLMSLPMETLAEVASQQSRTVPSNAS 285

Query: 83  RGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGV 142
            G+++Y RQEGR IGL  K++AY LQD G DTVEAN  L   AD R + L   M   LG+
Sbjct: 286 GGVIIYLRQEGRGIGLGEKLKAYNLQDLGSDTVEANLLLRHPADARSYGLATAMLVDLGL 345

Query: 143 ------NEVRLLTNNPKKVEILTEAGINIV--ERVPLIVGRNP----------NNEHYLD 184
                 + +RLLTNNP KV  +      +V  ERV ++                 E YL 
Sbjct: 346 GVDANPHGIRLLTNNPDKVRAVEGPNREVVVKERVAMVPLAWKTGGKMGIKSSEVEGYLR 405

Query: 185 TKAE 188
           TK  
Sbjct: 406 TKVR 409


>UniRef50_C5RMY3 GTP cyclohydrolase-2 n=1 Tax=Clostridium cellulovorans 743B
           RepID=C5RMY3_CLOCL
          Length = 175

 Score =  178 bits (451), Expect = 1e-43,   Method: Composition-based stats.
 Identities = 63/165 (38%), Positives = 92/165 (55%), Gaps = 3/165 (1%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVAL-VYGDISGHTPVLARVHSECLTGDALF 61
           LK+      PT +  F    F  L  G   V + +  D      +L R+HSEC   + L 
Sbjct: 6   LKKSEIFTFPTEYALFKAQVF-ILKDGTMPVVVSLNQDHLSLNDILVRIHSECFMSEVLS 64

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQ-GYDTVEANHQ 120
           S+RCDC  QL+ +L +IA EG+G+L Y RQEG+ +GL NK +AY LQ++      EA+  
Sbjct: 65  SIRCDCASQLKESLKRIASEGQGVLFYLRQEGKGMGLFNKAKAYYLQEKYQLSNYEADKM 124

Query: 121 LGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINI 165
            GF  D RD+    ++   + ++ +RLLTNN +K+  L E GIN+
Sbjct: 125 AGFPEDTRDYAFVVEVLNEMNIHSIRLLTNNDEKIRYLKENGINV 169


>UniRef50_Q5YVN1 GTP cyclohydrolase-2 n=1 Tax=Nocardia farcinica RepID=Q5YVN1_NOCFA
          Length = 256

 Score =  177 bits (449), Expect = 2e-43,   Method: Composition-based stats.
 Identities = 77/187 (41%), Positives = 96/187 (51%), Gaps = 6/187 (3%)

Query: 13  TPWGDFLMVGFEELATGHDH-VALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQL 71
           T  G  L V   EL    D    LV+G+I      L R+HS CL GDAL S  CDCG +L
Sbjct: 15  TRKGAELTVRVRELPADRDGGSVLVFGEIGQD--CLVRIHSRCLYGDALQSDDCDCGPEL 72

Query: 72  EAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQ-GYDTVEANHQLGFAADERDF 130
           E ++  I  EGRG+L+Y  QEGR  GL+ K R     ++ G DT  A  +LG+  D R F
Sbjct: 73  ERSMDLIQAEGRGVLVYLDQEGRGAGLVAKARGLREAERTGADTFTAYTRLGYPEDARSF 132

Query: 131 TLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIV-GRNPNNEHYLDTKAEK 189
            L A     LG+  VRLLTNNP K   LT+ G+ +   VPL    R+     YL  K   
Sbjct: 133 RLAAAAIAELGLRRVRLLTNNPDKAAALTDLGVAVT-VVPLTTRPRSARARKYLQDKRAH 191

Query: 190 MGHLLNK 196
             H L +
Sbjct: 192 RRHWLPE 198


>UniRef50_A2TRN2 GTP cyclohydrolase-2 n=1 Tax=Dokdonia donghaensis MED134
           RepID=A2TRN2_9FLAO
          Length = 170

 Score =  171 bits (434), Expect = 1e-41,   Method: Composition-based stats.
 Identities = 56/170 (32%), Positives = 88/170 (51%), Gaps = 2/170 (1%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           + ++A+  + T +G +  + F +     +  ALV GDISG   VL RVHS C+      S
Sbjct: 2   IVQLADGTIKTKYGIYKEILFYDGI--KESHALVMGDISGEEDVLCRVHSSCIFAHHFNS 59

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
           + CDC  Q+E +   I   G+GI+++  QEG+  G    +    L+ +G    +A   +G
Sbjct: 60  IECDCREQMEISQQLIERAGKGIVIWLEQEGKGNGHYALLNTLPLKKEGMPQADAYEAVG 119

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLI 172
           F  D RDF+  A + K L VN + ++T N KK + LT+ GI +    P  
Sbjct: 120 FHKDNRDFSAAAKILKHLEVNSITMITGNEKKTKTLTDLGIRVSGIQPTE 169


>UniRef50_Q6KH48 GTP cyclohydrolase-2 n=1 Tax=Mycoplasma mobile RepID=Q6KH48_MYCMO
          Length = 343

 Score =  171 bits (433), Expect = 1e-41,   Method: Composition-based stats.
 Identities = 61/184 (33%), Positives = 98/184 (53%), Gaps = 4/184 (2%)

Query: 11  LPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQ 70
           + T  G F M  FE  +   + V    GD+     V AR+H +C+T +   S+ CDC  Q
Sbjct: 162 METSDGFFNMKSFEVPSHNKEFVIKWNGDLKK--IVNARIHYKCMTSEVFGSIMCDCKDQ 219

Query: 71  LEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAY-ALQDQGYDTVEANHQLGFAADERD 129
           LE+    + +EG G+LLY  +EGR  G+L+K+ AY   + +G DTV+A  +     + R 
Sbjct: 220 LESFNELMKKEG-GLLLYAYEEGRGFGMLHKLNAYYNTEKEGLDTVDAMIKETGKTEARK 278

Query: 130 FTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAEK 189
           F +  ++ + LG+ EV L TNNP+K+  L +  I +  +      ++   + Y + K +K
Sbjct: 279 FDMAGEIIRKLGIKEVNLYTNNPRKIIPLLDRRIKVNRKKHWTETKSKEAKKYTEDKIKK 338

Query: 190 MGHL 193
           M HL
Sbjct: 339 MEHL 342


>UniRef50_Q08VV8 GTP cyclohydrolase-2 n=1 Tax=Stigmatella aurantiaca DW4/3-1
           RepID=Q08VV8_STIAU
          Length = 356

 Score =  168 bits (426), Expect = 9e-41,   Method: Composition-based stats.
 Identities = 64/150 (42%), Positives = 75/150 (50%), Gaps = 5/150 (3%)

Query: 49  RVHSECLTGDALFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQ 108
           R+HS C+T +A     CDC  QLE AL +IAE GRG + Y  QEGR  G   K R   L 
Sbjct: 2   RIHSACITSEAFGGCDCDCAEQLELALERIAEAGRGAVFYLMQEGRGAGYAAKARDRMLV 61

Query: 109 DQGYDTV---EANHQLGFAADERDFTLCADMFKLLGVN-EVRLLTNNPKKVEILTEAGIN 164
               DTV   EA   LG   D R +   A    LL V   VRLLTNNP+K   L   GI 
Sbjct: 62  QASCDTVSTFEAYRMLGLEPDSRRYHEVALALGLLKVRAPVRLLTNNPEKTRALKTLGIE 121

Query: 165 IVERVPLIVGRNPNNEHYLDTKAEKMGHLL 194
           +     +    NP N HYL +K  + GH L
Sbjct: 122 VEAAERIQREANPFNVHYLSSKR-REGHAL 150



 Score = 39.4 bits (91), Expect = 0.075,   Method: Composition-based stats.
 Identities = 23/103 (22%), Positives = 39/103 (37%), Gaps = 5/103 (4%)

Query: 18  FLMVGFEELATGHDHVALVYGDISGHT--PVLARVHSECLTGDALFSLRCDCGFQLEAAL 75
           F    + +L    + V L YG ++  +    L R+  E L  +           Q + A+
Sbjct: 201 FRAHVYFDLLASCERVVLTYGPLAEDSLRVPLVRIQRESLF-ERFPVRNGVHKSQWKWAV 259

Query: 76  TQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEAN 118
            ++ + G GI L+   +G +  L     A   Q  G    EA 
Sbjct: 260 AEMVQHGHGIALFPSADGDDAVLAAS--ALGAQSPGGRLAEAR 300


>UniRef50_A9QS81 GTP cyclohydrolase-2 n=1 Tax=Lactococcus lactis subsp. lactis KF147
           RepID=A9QS81_LACLK
          Length = 209

 Score =  163 bits (412), Expect = 4e-39,   Method: Composition-based stats.
 Identities = 61/197 (30%), Positives = 90/197 (45%), Gaps = 7/197 (3%)

Query: 2   QLKRVAEAKLPTPWGDFLMVGFEELATGH--DHVALVY-GDISGHTPVLARVHSECLTGD 58
           ++ +V++ +L    G F +  F     G   +H ALV   D      V  R++S C+T +
Sbjct: 9   KILKVSKGQLEIKNGVFTLYAFMIYYEGRCEEHYALVNSKDWKIDEAVPFRINSACVTSE 68

Query: 59  ALFSLRCDCGFQLEAALTQIAEEGRGILLYH-RQEGRNIGLLNKIRAYALQDQGYDTVEA 117
                +CDC +QL+ A+  I E G GI+ YH   EG   G+  K+ ++   + G D    
Sbjct: 69  VFGCEKCDCKWQLDEAIHYITEIGFGIITYHPNHEGLGHGIFEKLNSFN--ELGADNTSY 126

Query: 118 NHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIV-GRN 176
                   D R+F     +     +NEV LL NN KK+  L E G+NI   V LI  G N
Sbjct: 127 IDLNCEKEDARNFLPALIILDYFKINEVTLLGNNLKKIHFLMENGVNISGIVNLIYNGNN 186

Query: 177 PNNEHYLDTKAEKMGHL 193
              + Y+  K  K  H 
Sbjct: 187 RTTKKYILLKGRKPEHF 203


>UniRef50_A0M3F6 Riboflavin biosynthesis protein n=17 Tax=Bacteroidetes
           RepID=A0M3F6_GRAFK
          Length = 382

 Score =  149 bits (377), Expect = 4e-35,   Method: Composition-based stats.
 Identities = 42/169 (24%), Positives = 80/169 (47%), Gaps = 5/169 (2%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           +K+  + +L T +G F +  +E+      HVAL  G       ++ RV+S  +  D L +
Sbjct: 217 IKKKEDFELDTRFGKFRLRAYEQTTNSQVHVALTKGAWKPSEEIMVRVNSTLVNNDILGT 276

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
           L  +   +L+     I +EGRG +++     ++  LLN++     + Q    ++A     
Sbjct: 277 LTNNADKKLDGMFKAINDEGRGAIVFINPANQSPNLLNRLTELK-ESQKNGEIKAPP--- 332

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPK-KVEILTEAGINIVERVP 170
              D +DF + A +   L ++++RLL+N  + K   +   G+ I E V 
Sbjct: 333 VKMDNKDFGIGAQILHDLEIHKIRLLSNTQQSKRVGMIGYGLEITEYVS 381


>UniRef50_Q6MIV8 GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate
           synthase n=1 Tax=Bdellovibrio bacteriovorus
           RepID=Q6MIV8_BDEBA
          Length = 376

 Score =  148 bits (374), Expect = 1e-34,   Method: Composition-based stats.
 Identities = 46/171 (26%), Positives = 77/171 (45%), Gaps = 9/171 (5%)

Query: 3   LKRVAEAKLPTPWGDF-LMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALF 61
           ++ +    LP  +G+      F     G +H+ +  G+I    P L RVH +  T D + 
Sbjct: 208 VEELHSVPLPASFGENMQARVFRSTVDGLEHLVIQKGEIKKDHPTLVRVHVDNFTRDFMA 267

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
            ++      LE ++  I++E  G  +  R   R  GL  ++        G + +     L
Sbjct: 268 VVQRGASSVLE-SIKAISQEESGAFVLLRGNNRTSGLTQELNVLV----GLEDIRPTTPL 322

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLI 172
               DERD+ + A + + +G N++RLLTN P+K   L    I IVE V + 
Sbjct: 323 ---MDERDYGIGAQILREIGANKIRLLTNKPEKKVGLKAFDIEIVEIVAME 370


>UniRef50_C0YN89 3,4-dihydroxy-2-butanone-4-phosphate synthase n=1
           Tax=Chryseobacterium gleum ATCC 35910 RepID=C0YN89_9FLAO
          Length = 373

 Score =  148 bits (374), Expect = 1e-34,   Method: Composition-based stats.
 Identities = 43/169 (25%), Positives = 72/169 (42%), Gaps = 5/169 (2%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           ++R+ E K+ T +GDF    F E +    H AL  G  +   PVL RV S     D L  
Sbjct: 210 VERIEERKVKTFYGDFDFYAFRETSNEQIHFALTKGAWTVDEPVLVRVQSSDSYFDVLTR 269

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
           L       LE     + E G+G +++      +   L K++ +     G +         
Sbjct: 270 LNNGEKPLLEKVTNMVNEAGKGAIIFINNVSNSENTLRKLQQFLNYQDGQE-----QHPT 324

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPL 171
            A + RD+ +   + K LG+N+ +++T NP     +    + + E V L
Sbjct: 325 LAYNYRDYGIGTQILKNLGINKFKVITQNPNIKPQVGGYDVEVTEMVQL 373


>UniRef50_B5JMM0 3,4-dihydroxy-2-butanone 4-phosphate synthase family n=1
           Tax=Verrucomicrobiae bacterium DG1235 RepID=B5JMM0_9BACT
          Length = 360

 Score =  145 bits (367), Expect = 7e-34,   Method: Composition-based stats.
 Identities = 48/169 (28%), Positives = 75/169 (44%), Gaps = 21/169 (12%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           ++ + E    +  G+F M  F  L  G +HVALV G+I   T  L RVH+E +  D    
Sbjct: 213 VELIREQPFSSVHGEFSMKVFRSLLDGREHVALVAGEICSET-TLVRVHAENVVKDLFHP 271

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
                   +  A+ +IAEEG G ++Y R+ G  +                    AN    
Sbjct: 272 SDAGAEDSIGLAMKRIAEEGCGAIVYIRRPGGGL--------------------ANSPED 311

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPL 171
            +   R++ + A +   LG+ ++RLL+   + V  L   G+ IVE V L
Sbjct: 312 KSMGLREYGIGAQILSSLGLQKIRLLSQTNRNVIALDGYGLEIVETVGL 360


>UniRef50_C6X067 3,4-dihydroxy-2-butanone 4-phosphate synthase / GTP cyclohydrolase
           II n=1 Tax=Flavobacteriaceae bacterium 3519-10
           RepID=C6X067_FLAB3
          Length = 416

 Score =  144 bits (365), Expect = 1e-33,   Method: Composition-based stats.
 Identities = 44/169 (26%), Positives = 74/169 (43%), Gaps = 5/169 (2%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           ++R+ E K+ T +GDF    F+E +T   H AL  G      PVL RV +     D L  
Sbjct: 253 IERIEERKVKTHYGDFDFFAFKETSTDQIHFALTKGTWVVDEPVLVRVQASNAYFDVLSR 312

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
           L       LE     I EEG+G L++          L K++ +     G +      +  
Sbjct: 313 LTAGEKPLLEKVTNMINEEGKGALIFINNVSTAENTLRKLQQFIDFQDGQE-----KRPT 367

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPL 171
            A++  D+ +   + K LG+ + R++T N  +  ++    + + E V L
Sbjct: 368 LASNFHDYGIGTQILKNLGITKFRVITQNVNQKPLVGGYDVEVTEMVQL 416


>UniRef50_A0SNY4 Riboflavin biosynthesis protein RibA n=2 Tax=Candidatus
           Micrarchaeum acidiphilum ARMAN-2 RepID=A0SNY4_9EURY
          Length = 251

 Score =  144 bits (363), Expect = 2e-33,   Method: Composition-based stats.
 Identities = 51/206 (24%), Positives = 91/206 (44%), Gaps = 17/206 (8%)

Query: 1   MQLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGD---------ISGHTPVLARVH 51
            +++R+A   + T +G+F++  F+      D+  LV                  +L +  
Sbjct: 43  FEVRRIAVGPIITRFGNFMIYEFKINDRWKDYEVLVNAKAFDKDFMPLFERGRELLIKTD 102

Query: 52  SECLTGDALFSLRCDCGFQLEAALTQIAEEGRGILLYH-RQEGRNIGLLNKIRAYALQDQ 110
           S C TG+      C C  QL +A+  I + G G+++    QEGR  G   K     LQ +
Sbjct: 103 SGCRTGEIYLDRTCTCRQQLHSAMETIGKRGNGLIITIPNQEGRGHGYAKKYATLVLQKE 162

Query: 111 -GYDTVEANHQLGFAADERDFTLCADMFKLLGV---NEVRLLTNNPKKVEILTEAGINIV 166
            GYDT EA+  +    D RD+     + K  G+   + + ++ NN  K++ + E G +  
Sbjct: 163 LGYDTYEASKAVNKKVDVRDYYGAVAILKFFGIGQSHRLEVIANNNSKLKEVLENGYS-- 220

Query: 167 ERVPLI-VGRNPNNEHYLDTKAEKMG 191
            R+    +  +     +L  K +K+G
Sbjct: 221 ARLAKQDIRADRYTIKHLMAKRDKLG 246


>UniRef50_Q2NZ90 3,4-dihydroxy-2-butanone 4-phosphate synthase n=11
           Tax=Gammaproteobacteria RepID=Q2NZ90_XANOM
          Length = 379

 Score =  141 bits (356), Expect = 1e-32,   Method: Composition-based stats.
 Identities = 47/173 (27%), Positives = 74/173 (42%), Gaps = 10/173 (5%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           ++RV E  + T +G F +V + +      H ALV G    HTP L RV  E    D L  
Sbjct: 206 VERVDERDITTEFGPFKLVTYRDRIAHDLHFALVRGSADPHTPTLVRVQVENPLADLLHW 265

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
            R D G     AL  IA EG+G+++       +  LL ++R            EA     
Sbjct: 266 QRDDFGVAATDALRAIAAEGQGVMVVLSAPRDSESLLARLRQQP---------EAAANAK 316

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGR 175
             +  R     A +   LG+ ++R+L  + ++V  +   G+ +VE +    G 
Sbjct: 317 DVSQWRRHGAGAQILAELGLGKLRVLGTSRRQV-GVAGFGLEVVEYLECHAGE 368


>UniRef50_A6DFW1 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
           n=1 Tax=Lentisphaera araneosa HTCC2155
           RepID=A6DFW1_9BACT
          Length = 360

 Score =  140 bits (353), Expect = 3e-32,   Method: Composition-based stats.
 Identities = 46/176 (26%), Positives = 82/176 (46%), Gaps = 15/176 (8%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALV----YGDISGHTPVLARVHSECLTGD 58
           ++ +    +PT +GDF +  +  +      + LV             VL RVHSE   G+
Sbjct: 189 VEALNIVNMPTDYGDFRLHVYNVIYDPARGIDLVLTCGKDKFDEDETVLVRVHSEWSIGN 248

Query: 59  ALFSLRCDCGFQLEAALTQIAEEGRGILLYHRQ---EGRNIGLLNKIRAYALQDQGYDTV 115
            +  L+ + G  L  A+ Q+A+EG GI+++ R    +  N GL +  +      +  D  
Sbjct: 249 IVNRLKNEEGSSLNRAMKQVADEGSGIIVFLRNTPEQAANSGLFSDSK------RPTDIW 302

Query: 116 EANHQLGF--AADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERV 169
             N ++      D   + L A + + LGV ++RL++N+P     +   G+ IVE+V
Sbjct: 303 MENGEIKTLRPKDGMAYGLGAQILRDLGVRKMRLMSNSPSSFIGINNYGLEIVEQV 358


>UniRef50_Q882G0 3,4-dihydroxy-2-butanone 4-phosphate synthase n=38
           Tax=Proteobacteria RepID=RIBB_PSESM
          Length = 369

 Score =  139 bits (352), Expect = 3e-32,   Method: Composition-based stats.
 Identities = 45/172 (26%), Positives = 76/172 (44%), Gaps = 9/172 (5%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           + R+ E +LPT  G F +  +E+   G  H+A+V GDI    P L RVH      D + +
Sbjct: 206 IVRIGERELPTVHGTFRLFSYEDRIEGGVHMAMVMGDIRREDPTLVRVHVVDPLRDLVGA 265

Query: 63  -LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
                  + L AAL ++AEEG G+++       +  LL +I       + Y   ++    
Sbjct: 266 EYTGPANWTLWAALQRVAEEGCGVVVVLANHESSQALLERIPQLTQPPRQYTRSQSRI-- 323

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIV 173
                  +    A + + LG+ ++R L   P K   LT   + ++E +P   
Sbjct: 324 -----YSEVGTGAQILQDLGIGKLRHL-GPPLKYAGLTGYDLEVIESIPFPG 369


>UniRef50_C5FIC6 GTP cyclohydrolase-2 n=1 Tax=Microsporum canis CBS 113480
           RepID=C5FIC6_NANOT
          Length = 519

 Score =  139 bits (352), Expect = 4e-32,   Method: Composition-based stats.
 Identities = 42/155 (27%), Positives = 71/155 (45%), Gaps = 11/155 (7%)

Query: 36  VYGDI----SGHTPVLARVHSECLTGDALFSLRCDCGFQL----EAALTQIAEEGRGILL 87
           ++GD       +  +  R+H EC   D   S  C C   L    E A+ +  + G G+++
Sbjct: 321 IFGDPAKMADPNAKLALRIHDECNGSDVFGSDICTCRPYLIFGVEEAVKEAQKGGSGVVI 380

Query: 88  YHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNEV-R 146
           Y R+EGR +G + K   Y  +   Y   +    +    D R   L  D+   LG+ ++ R
Sbjct: 381 YFRKEGRALGEVTKYLVYNARASEY--FKRTENIAGVKDMRFQALMPDILHWLGITKIDR 438

Query: 147 LLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181
           +L+ +  K + + E GI I+ERVP+     P +  
Sbjct: 439 MLSMSNMKHDAIVEQGIPILERVPIPDELIPEDSR 473


>UniRef50_A7IMW5 3,4-dihydroxy-2-butanone 4-phosphate synthase n=93
           Tax=Alphaproteobacteria RepID=A7IMW5_XANP2
          Length = 437

 Score =  137 bits (346), Expect = 2e-31,   Method: Composition-based stats.
 Identities = 45/169 (26%), Positives = 72/169 (42%), Gaps = 14/169 (8%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           + R AE  +PT  G+     +       +H+ALV G I     VL R+H      DA   
Sbjct: 281 VTRAAEFPVPTCVGELQGFSYVTPFDPVNHLALVKGRIGDGEKVLVRLHRADPIADAFGG 340

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
                G  ++ AL +I  EGRG+L+Y R     +              G+   +++ ++ 
Sbjct: 341 -----GKTIQRALERIEAEGRGVLVYLRDGTAGV---------PAVAMGHGGEKSSSEIE 386

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPL 171
                R+  L A + + LG+  +RLL +  +    L   GI IV+  PL
Sbjct: 387 RDRHWREVGLGAQILRDLGIVSIRLLASKSRTYVGLAGFGIEIVDTEPL 435


>UniRef50_Q9R6K1 GTP cyclohydrolase-2 n=1 Tax=Agrobacterium tumefaciens
           RepID=Q9R6K1_RHIRD
          Length = 190

 Score =  133 bits (336), Expect = 2e-30,   Method: Composition-based stats.
 Identities = 48/172 (27%), Positives = 79/172 (45%), Gaps = 7/172 (4%)

Query: 4   KRVAEAKLPTPWGDFLMVGFEELATGH--DHVALVYGDISGHTPVLARVHSECLTGDALF 61
           + V + ++    G F        A     DH+A      S   P+  R+ S C+ G    
Sbjct: 22  EVVRDVEIENSIGTFSAACIRVKANNETTDHLAFYK---SIGVPLTLRIQSGCVLGHVFG 78

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYH-RQEGRNIGLLNKIRAYAL-QDQGYDTVEANH 119
              CDC  QL+ +L  I  +  G+++Y    + R  G+ +K++ Y   Q++  D+  A  
Sbjct: 79  DNECDCKAQLDKSLRYIHSQNEGMVIYTPSHDARGRGIYSKLQIYRTRQERCIDSAAACR 138

Query: 120 QLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPL 171
           + G   D RDF+  + +  +  V  V LL  +  K + L EAGI++V  VPL
Sbjct: 139 ETGVPFDTRDFSQFSSILGVFDVKSVALLGRSAAKAKALIEAGISVVSSVPL 190


>UniRef50_B4RM34 3,4-dihydroxy-2-butanone 4-phosphate synthase n=47
           Tax=Proteobacteria RepID=B4RM34_NEIG2
          Length = 445

 Score =  133 bits (335), Expect = 4e-30,   Method: Composition-based stats.
 Identities = 38/165 (23%), Positives = 67/165 (40%), Gaps = 14/165 (8%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           L+ + +A + TPWG+F    + +  +G  H+ALV G  S  T  L RVH      D    
Sbjct: 289 LEDMGDAPVQTPWGEFQQHVYVDKLSGETHLALVKGTPSADTETLVRVHEPFSVMD-FIQ 347

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
                 + L  AL ++ +   G+++          LL++            T+       
Sbjct: 348 ANPRHSWSLPKALERVQQAESGVVILLHHTEDGASLLDR------------TLPKGANQA 395

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVE 167
           +  D + + + A +   L V ++R+L   P     LT  G+ +V 
Sbjct: 396 YKWDSKSYGIGAQILAGLHVKKLRVLGQ-PSSFTGLTGFGLEVVG 439


>UniRef50_D2UG04 Putative gtp cyclohydrolase II 3, 4-dihydroxy-2-butanone
           4-phosphate synthase, riboflavin biosynthesis protein
           n=1 Tax=Xanthomonas albilineans RepID=D2UG04_XANAL
          Length = 385

 Score =  133 bits (334), Expect = 4e-30,   Method: Composition-based stats.
 Identities = 43/161 (26%), Positives = 67/161 (41%), Gaps = 11/161 (6%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           ++R+ E  + T +GDF +V + +      H ALV G +   TP L RV  E    D L  
Sbjct: 214 VERIDERPIVTEFGDFTLVTYRDRIAHDLHFALVRGPLDADTPTLVRVQVENPLADLLHW 273

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
            R D G     AL  IA   RG+++       +  LL ++RA      G D         
Sbjct: 274 RREDFGVAASDALRAIATADRGVMVVLSAPRDSQALLARLRAQPEAAHGKD--------- 324

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGI 163
                R     + +   LG+ ++R+L   P++   L   G+
Sbjct: 325 -VGQWRRNGAGSQILADLGLGKLRVL-GTPRRQIGLAGFGL 363


>UniRef50_Q1DG18 GTP cyclohydrolase-2 n=2 Tax=Bacteria RepID=Q1DG18_MYXXD
          Length = 454

 Score =  132 bits (333), Expect = 6e-30,   Method: Composition-based stats.
 Identities = 47/173 (27%), Positives = 74/173 (42%), Gaps = 22/173 (12%)

Query: 11  LPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQ 70
           LP P G   +  F     G + +A          P+  RVH EC   D   S  C C   
Sbjct: 251 LP-PIGGLTLYVF----GGIETLA------DRDVPLTVRVHDECNGSDVFGSDICTCRPY 299

Query: 71  L----EAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYAL--QDQGYDT----VEANHQ 120
           L    E  +      G G+++Y R+EGR +G + K   Y    + +G D+     +    
Sbjct: 300 LAHGIEECVRTAQAGGAGLIVYLRKEGRALGEVTKFLVYNARKRQEGGDSAATYFQRTEC 359

Query: 121 LGFAADERDFTLCADMFKLLGVNEV-RLLTNNPKKVEILTEAGINIVERVPLI 172
           +    D R   L  D+   LG+  + R ++ +  K + +T +GI I+ERVP+ 
Sbjct: 360 VAGVQDMRFQELMPDVLHWLGITRIHRFVSMSDMKHDAITRSGIEILERVPIP 412


>UniRef50_D0NXG3 Putative uncharacterized protein n=1 Tax=Phytophthora infestans
           T30-4 RepID=D0NXG3_PHYIN
          Length = 459

 Score =  132 bits (333), Expect = 6e-30,   Method: Composition-based stats.
 Identities = 41/143 (28%), Positives = 65/143 (45%), Gaps = 11/143 (7%)

Query: 41  SGHTPVLARVHSECLTGDALFSLRCDCGFQL----EAALTQIAEEGRGILLYHRQEGRNI 96
                +  RVH EC   D   S  C C   L    E  +    E G GI++Y R+EGR +
Sbjct: 269 DPTKKLAVRVHDECNGSDVFGSDICTCRPYLAHGIEVCVQTAQEGGAGIIVYFRKEGRAL 328

Query: 97  GLLNKIRAYAL--QDQGYDTVEA----NHQLGFAADERDFTLCADMFKLLGVNEV-RLLT 149
           G + K   Y L  + +G D+ E        +    D R   L  D    LG+ ++ + ++
Sbjct: 329 GEVTKYLVYNLRKRQEGGDSAEEYFNCTQTVAGIQDVRFQALMPDALHWLGITKIDKFVS 388

Query: 150 NNPKKVEILTEAGINIVERVPLI 172
            +  K + + ++GI IVER+P+ 
Sbjct: 389 MSDMKYDAIVKSGIEIVERIPIP 411


>UniRef50_D1ZD95 GTP cyclohydrolase-2 n=1 Tax=Sordaria macrospora RepID=D1ZD95_SORMA
          Length = 528

 Score =  132 bits (332), Expect = 8e-30,   Method: Composition-based stats.
 Identities = 48/189 (25%), Positives = 73/189 (38%), Gaps = 38/189 (20%)

Query: 11  LPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQ 70
           LP P G   +  F + A   D              +  R+H EC   D   S  C C   
Sbjct: 306 LP-PIGGLTVYCFGDPANMSD----------PSKKLALRIHDECNGSDVFCSDICTCRPY 354

Query: 71  L----EAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQ------------------ 108
           L    E A+ +  + G G+++Y R+EGR +G + K R   LQ                  
Sbjct: 355 LIFGIEEAVKEAQKGGSGVVIYFRKEGRALGEVTKYRMSNLQTMLTFSCVEEFLIVYNAR 414

Query: 109 ----DQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNEV-RLLTNNPKKVEILTEAGI 163
               D   D  +    +    D R   L  D+   LG+ ++ R+L+ +  K + +   GI
Sbjct: 415 KRGADLASDYFKRTENIAGVKDMRFQALMPDILHWLGITKIDRMLSMSNMKHDAIVGQGI 474

Query: 164 NIVERVPLI 172
            I+ERV L 
Sbjct: 475 PIIERVELP 483


>UniRef50_B7FNY5 Predicted protein n=1 Tax=Phaeodactylum tricornutum CCAP 1055/1
           RepID=B7FNY5_PHATR
          Length = 494

 Score =  132 bits (332), Expect = 8e-30,   Method: Composition-based stats.
 Identities = 41/153 (26%), Positives = 64/153 (41%), Gaps = 11/153 (7%)

Query: 40  ISGHTPVLARVHSECLTGDALFSLRCDCGFQL----EAALTQIAEEGRGILLYHRQEGRN 95
                 +  RVH EC   D   S  C C   L    E  +    + G GI++Y+R+EGR+
Sbjct: 301 PDEDIELTCRVHDECNGSDVFGSDICTCRPYLTHAIEECIRTAQKGGCGIVIYYRKEGRS 360

Query: 96  IGLLNKIRAYAL--QDQGYDTVE----ANHQLGFAADERDFTLCADMFKLLGVNEV-RLL 148
           +G + K   Y    + +G D+ E       Q+    D R   L  D    LGV ++   +
Sbjct: 361 LGEVTKYLVYNTRKRQEGGDSAERYFSCTEQVAGVQDTRFQALMPDPLHFLGVTKIDNFI 420

Query: 149 TNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181
           + +  K + +   GI IV RV +     P +  
Sbjct: 421 SMSDMKYDAIVSTGIKIVNRVEIPPEMVPEDAK 453


>UniRef50_Q5K843 GTP cyclohydrolase-2 n=5 Tax=Eukaryota RepID=Q5K843_CRYNE
          Length = 562

 Score =  130 bits (327), Expect = 3e-29,   Method: Composition-based stats.
 Identities = 36/150 (24%), Positives = 61/150 (40%), Gaps = 13/150 (8%)

Query: 36  VYGDI----SGHTPVLARVHSECLTGDALFSLRCDCGFQL----EAALTQIAEEGRGILL 87
           + GD        T V  R H  C   D   S  C C   L      A+      G G+++
Sbjct: 369 IMGDPAKLQDPDTEVTCRPHDSCSGSDVFGSDICTCRPYLIFGISEAIKCAQRGGVGVIV 428

Query: 88  YHRQEGRNIGLLNKIRAYALQDQGYDTVEA----NHQLGFAADERDFTLCADMFKLLGVN 143
           Y ++EGR +G + K   Y  + +G DT         ++    D R   L  D+   LG+ 
Sbjct: 429 YFQKEGRALGEVVKYMVYNRRKRGGDTAAEYFNNTERVAGVKDARHQALMPDVLHFLGIK 488

Query: 144 EV-RLLTNNPKKVEILTEAGINIVERVPLI 172
            +  L++ +  K + +  +GI + +R  + 
Sbjct: 489 HIHNLISMSNMKYDAIIGSGITVGKRYEIP 518


>UniRef50_Q9US41 Uracil-regulated protein 1 n=101 Tax=cellular organisms
           RepID=URG1_SCHPO
          Length = 439

 Score =  129 bits (325), Expect = 5e-29,   Method: Composition-based stats.
 Identities = 39/152 (25%), Positives = 65/152 (42%), Gaps = 13/152 (8%)

Query: 34  ALVYGDI----SGHTPVLARVHSECLTGDALFSLRCDCGFQL----EAALTQIAEEGRGI 85
           A ++G           +  RVH EC   D   S  C C   L    E A  +    G G+
Sbjct: 249 AYIFGPPEYLSDTSKSLAVRVHDECNGSDVFQSDICTCRPYLTFGIEEAAKEAQNGGAGL 308

Query: 86  LLYHRQEGRNIGLLNKIRAYALQDQGYDTVE----ANHQLGFAADERDFTLCADMFKLLG 141
           ++Y R+EGR +G + K   Y  + +  D+ E       +L    D R   L  D+    G
Sbjct: 309 VVYFRKEGRALGEVVKYLVYNKRKRTGDSAENYFKRTEELAGVRDMRFQALMPDILHWFG 368

Query: 142 VNEV-RLLTNNPKKVEILTEAGINIVERVPLI 172
           + ++ R+L+ +  K + +   GI I+ R+ + 
Sbjct: 369 IKKIDRMLSMSNMKHDAIVGQGIKILNRITIP 400


>UniRef50_A4A6E4 Riboflavin biosynthesis protein ribA n=5 Tax=unclassified
           Gammaproteobacteria RepID=A4A6E4_9GAMM
          Length = 380

 Score =  127 bits (319), Expect = 2e-28,   Method: Composition-based stats.
 Identities = 43/173 (24%), Positives = 85/173 (49%), Gaps = 11/173 (6%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           ++RV E  + T +G+F +  + +   G  H+AL  G+IS   P L RVH+     D L S
Sbjct: 212 IERVREGVISTRYGNFQLATYRDRTHGGLHIALSLGEISATEPTLVRVHATSTLRDLLGS 271

Query: 63  -LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
            ++   G+ ++ +L  IA+ G G+L+   +   +  LL+ +      D     +E     
Sbjct: 272 DVQGQVGWSVQRSLAAIAKSGSGVLVLLGRSETDEQLLHSV------DLALGEIEPRDP- 324

Query: 122 GFAADERDF-TLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIV 173
             A+D  +   + + + + LGV ++RL+   P K   ++  G+ +++ +  +V
Sbjct: 325 -KASDSYNTVGVGSQILRELGVGKIRLM-GAPIKYNAISGFGLEVIDYLEPVV 375


>UniRef50_Q1AZ21 GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate
           synthase n=2 Tax=Bacteria RepID=Q1AZ21_RUBXD
          Length = 366

 Score =  124 bits (313), Expect = 1e-27,   Method: Composition-based stats.
 Identities = 46/147 (31%), Positives = 70/147 (47%), Gaps = 19/147 (12%)

Query: 2   QLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALF 61
            ++ + E  LPT +G+F +  +  ++TG  H AL+ G+   + P L  V + C TGDAL 
Sbjct: 205 HVRCLGEEALPTRFGEFRLRSYAGVSTGLIHRALLAGEPGENGPPLVGVRAACPTGDALH 264

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
           SLRCDCG +L  A+ ++A EG G++LY    G    L                       
Sbjct: 265 SLRCDCGERLRDAMERVAAEGEGVILYL-HPGPGAPLH------------------PLPG 305

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLL 148
           G   D   +    ++ + LG+  VRLL
Sbjct: 306 GEDEDLAPYRAGVEILRDLGLGRVRLL 332


>UniRef50_A6RZS8 GTP cyclohydrolase-2 n=1 Tax=Botryotinia fuckeliana B05.10
           RepID=A6RZS8_BOTFB
          Length = 470

 Score =  120 bits (301), Expect = 3e-26,   Method: Composition-based stats.
 Identities = 39/149 (26%), Positives = 61/149 (40%), Gaps = 22/149 (14%)

Query: 36  VYGDISGHTPVLAR----VHSECLTGDALFSLRCDCGFQL----EAALTQIAEEGRGILL 87
            +GD +  +    R    VH EC   D   S  C C   L    E A+ +  + G G++ 
Sbjct: 266 CFGDPAKMSDENVRLALRVHDECNGSDVFGSDICTCRPYLIYGIEEAVKEAQKGGSGVI- 324

Query: 88  YHRQEGRNIGLLNKIRAYALQDQGYDT----VEANHQLGFAADERDFTLCADMFKLLGVN 143
           Y R+EGR +G + K   Y  + +G D      +    +    D R   L  D+   LG+ 
Sbjct: 325 YFRKEGRALGEVTKYLVYNARKRGLDRASEYFKRTENIAGVKDMRFQALMPDILHWLGIK 384

Query: 144 EVRLLTNNPKKVEILTEAGINIVERVPLI 172
           ++           +L+ + I I ERV L 
Sbjct: 385 KID---------RMLSMSKIPIHERVELP 404


>UniRef50_A8PF74 GTP cyclohydrolase-2 n=1 Tax=Coprinopsis cinerea okayama7#130
           RepID=A8PF74_COPC7
          Length = 513

 Score =  118 bits (297), Expect = 8e-26,   Method: Composition-based stats.
 Identities = 33/124 (26%), Positives = 58/124 (46%), Gaps = 9/124 (7%)

Query: 54  CLTGDALFSLRCDCGFQL----EAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQD 109
           C   D   S  C C   L    E  +    + G G++ Y R+EGR +G + K   Y L+ 
Sbjct: 341 CNGSDVFGSDICTCKPYLVYAIEECIRGAQKGGVGVVAYFRKEGRALGEVTKYLVYNLRK 400

Query: 110 QGYDTVE----ANHQLGFAADERDFTLCADMFKLLGVNEV-RLLTNNPKKVEILTEAGIN 164
           +G D+ +    +   +    D R   L  D+   LG+ +V R+++ +  K + + ++GI 
Sbjct: 401 RGGDSADKYFKSTEMIAGVKDMRFQALMPDVLHWLGIRKVDRMVSMSDMKYDAIVKSGIP 460

Query: 165 IVER 168
           I+ R
Sbjct: 461 ILTR 464


>UniRef50_Q1GEQ5 GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate
           synthase n=12 Tax=Alphaproteobacteria RepID=Q1GEQ5_SILST
          Length = 374

 Score =  118 bits (297), Expect = 9e-26,   Method: Composition-based stats.
 Identities = 50/172 (29%), Positives = 79/172 (45%), Gaps = 23/172 (13%)

Query: 3   LKRVAEAKLPTPWG-DFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALF 61
           +   A + + + +G D+ M  F +     +HV L+ GDI+   PVL R H+     D L 
Sbjct: 220 VDETARSTVTSEYGGDWEMRIFTDQTHDVEHVVLIKGDITTPEPVLTRTHALHEASDLLG 279

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
            L      +L  A+  IA+EGRGI+   RQ    +        YA  ++G  T++     
Sbjct: 280 -LGPKPAGELPRAMELIADEGRGIVCLFRQPRNAL--------YASDEEGVRTIKQT--- 327

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPK-KVEILTEAGINIVERVPLI 172
                     L A +   LGV E+ LLT++P+ K   L   G++IV   P++
Sbjct: 328 ---------GLGAQILNKLGVEELILLTDSPQTKYVGLDAYGLSIVGTRPIL 370


>UniRef50_A6G9U6 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
           n=1 Tax=Plesiocystis pacifica SIR-1 RepID=A6G9U6_9DELT
          Length = 383

 Score =  116 bits (290), Expect = 6e-25,   Method: Composition-based stats.
 Identities = 50/158 (31%), Positives = 73/158 (46%), Gaps = 6/158 (3%)

Query: 18  FLMVGFEELATG-HDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALT 76
           + +  F  L       +AL  GD+SG  PVL R     L GD       D   +L A+L 
Sbjct: 231 WTIRSFRSLVEPVGRFIALTKGDLSGDDPVLLRAQRAQLVGDVFG-FGDDSATRLRASLA 289

Query: 77  QIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADM 136
           +I EEGRG  LY        G   +   +   ++G +  EA       +  RDF L A +
Sbjct: 290 RIDEEGRGAFLYVLG---GSGYDVEAELHLAGERG-ELPEAPGLRPRESGFRDFGLGAQV 345

Query: 137 FKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVG 174
            K +GV+++R+LTNNP+K+  L   GI +V    +   
Sbjct: 346 LKHMGVSKIRVLTNNPRKIVGLEGFGIEVVGSAGIQAP 383


>UniRef50_Q1AV39 GTP cyclohydrolase-2 n=1 Tax=Rubrobacter xylanophilus DSM 9941
           RepID=Q1AV39_RUBXD
          Length = 152

 Score =  114 bits (286), Expect = 2e-24,   Method: Composition-based stats.
 Identities = 48/147 (32%), Positives = 70/147 (47%), Gaps = 20/147 (13%)

Query: 2   QLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALF 61
           +L+R AEA+LPT +G+F +V + +   G  H+ALV G++ G   V A +H  CL G+A  
Sbjct: 18  RLRREAEARLPTRFGEFRVVAYRDAVDGRAHLALVAGEVRGRGRVFAHIHRSCLLGEAFG 77

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
           SL C CG  LE A+ +   EGRG++ Y                            A+   
Sbjct: 78  SLGCGCGALLEGAMQRAQREGRGVIAYV--------------------ARGGGAPASGAG 117

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLL 148
                E    + A +F+ LG+  VRLL
Sbjct: 118 CPKDGEGACAVGAAIFEDLGLRSVRLL 144


>UniRef50_A4JQ12 GTP cyclohydrolase II n=9 Tax=Proteobacteria RepID=A4JQ12_BURVG
          Length = 382

 Score =  114 bits (285), Expect = 2e-24,   Method: Composition-based stats.
 Identities = 43/179 (24%), Positives = 74/179 (41%), Gaps = 27/179 (15%)

Query: 2   QLKRVAEAKLPTPWGDF--------LMVGFEELATGHDHVALVYGDISGHTPVLARVHSE 53
           + +R+ EA      G F         +V +       +H+A V GD+ G  PVL R+H+ 
Sbjct: 215 RTERLVEA---VEHGSFTEPNGRHWRIVVYRNRIDQVEHIAFVMGDLRGADPVLVRMHAM 271

Query: 54  CLTGDALFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYD 113
               D +          L  A   +  E RG+++  R E R   +  ++RA         
Sbjct: 272 DTMNDVIGGH---HLASLRGAARLLENENRGVIVVIR-ESRLTAVSERVRAMM------- 320

Query: 114 TVEANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLI 172
                H      + RD+ + A +   LGV  + LL+N+ + +  L   G+N+VE+  + 
Sbjct: 321 -----HPKPAEPELRDYGIGAQILTELGVKNMILLSNHERTIVGLEGYGLNMVEQRKIE 374


>UniRef50_A0PS46 Riboflavin biosynthesis protein RibA1 n=16 Tax=Corynebacterineae
           RepID=A0PS46_MYCUA
          Length = 365

 Score =  111 bits (278), Expect = 1e-23,   Method: Composition-based stats.
 Identities = 40/104 (38%), Positives = 57/104 (54%), Gaps = 5/104 (4%)

Query: 2   QLKRVAEAKLPTPWGDFLMVGFEELAT---GHDHVALVYGDISGHTPVLARVHSECLTGD 58
           Q+ R+ E  LPT  G+  ++GF +L     G +H+A+V G      PV   VH ECLTGD
Sbjct: 201 QVIRLTETTLPTWAGNSRVIGFRDLGPANPGGEHLAVVIGAPDSGVPVALHVHIECLTGD 260

Query: 59  ALFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEG--RNIGLLN 100
              S  C CG +L  AL+ ++ +G G++LY +  G  R  GL  
Sbjct: 261 VFGSTGCRCGGELNGALSAMSAQGSGVVLYLQPPGPPRACGLFA 304


>UniRef50_B2AIS6 RIBOFLAVIN BIOSYNTHESIS BIFUNCTIONAL PROTEIN : GTP CYCLOHYDROLASE
           II AND 3, 4-DIHYDROXY-2-BUTANONE-4-PHOSPHATE SYNTHASE
           (DHBP SYNTHASE) n=3 Tax=Cupriavidus RepID=B2AIS6_CUPTR
          Length = 366

 Score =  110 bits (275), Expect = 3e-23,   Method: Composition-based stats.
 Identities = 44/169 (26%), Positives = 76/169 (44%), Gaps = 13/169 (7%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDAL-F 61
           L+R   ++L TP+G F +  + +      H+ALV G    HTPVL RV +  +  D L F
Sbjct: 208 LRRTRSSELATPFGRFTVHAYHDAPVDALHLALVLGRPDPHTPVLTRVQAVEMQRDVLAF 267

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
                  + LE +L +I  EG G+L+   +       L+++ A A         +     
Sbjct: 268 GTPAQPAWNLERSLERIGAEGCGVLVLLDERESPQQRLDRLAAPAAAAPAPAFAQ----- 322

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVP 170
                 R   + A + + +G +++RLL+ +P     +T   + + E VP
Sbjct: 323 ------RALGVGAQILRDVGAHKLRLLS-HPVPYRAVTGFDLEVTEFVP 364


>UniRef50_D0LW49 3,4-dihydroxy-2-butanone 4-phosphate synthase n=2 Tax=cellular
           organisms RepID=D0LW49_HALO1
          Length = 408

 Score =  109 bits (273), Expect = 5e-23,   Method: Composition-based stats.
 Identities = 46/162 (28%), Positives = 76/162 (46%), Gaps = 15/162 (9%)

Query: 17  DFLMVGFEELATGHDHVALVYGDISGHTPV----LARVHSECLTGDALFSLRCDCGFQLE 72
            F    +       +++ALV GD++         L RV S    GD           +L 
Sbjct: 226 PFQCAIYGAQVEDTEYMALVRGDVAAAGAADEAVLVRVQSVSPVGDTFGV-----KPELA 280

Query: 73  AALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADE-RDFT 131
           AAL  I + G G+ LY   + R+  L +  R +AL++     +E     G  ++  RDF 
Sbjct: 281 AALRTIDDAGVGVCLYVYNKARS-SLEHDFRKHALREA----IEPPAGGGAHSETLRDFG 335

Query: 132 LCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIV 173
           L A +   LG ++VRLL+N+ +++  +   GI +VERV + +
Sbjct: 336 LGAQVLADLGCHKVRLLSNSSRRIAGIEGFGIEVVERVAIDI 377


>UniRef50_Q2G801 GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate
           synthase n=74 Tax=cellular organisms RepID=Q2G801_NOVAD
          Length = 424

 Score =  107 bits (268), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 36/171 (21%), Positives = 68/171 (39%), Gaps = 18/171 (10%)

Query: 3   LKRVAEAKLPTPWG-DFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALF 61
           ++   +A   T +G ++ +  +     G  H+ L  G +    P L R+H+  +  D L 
Sbjct: 269 VECANQAPFHTDYGGEWTIKTYRNKVDGSAHLVLQKGAVVPGKPTLVRMHAISVLSDVLG 328

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
                    L+ A+T I E G G+++                   L ++   T       
Sbjct: 329 QPGPR-KRILQRAMTAIGEAGSGVIVLLMP----------TDPQQLMNEVAGTA------ 371

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLI 172
           G   + R + + A +   LGV+++ LLTN+   +  L   G++IV    + 
Sbjct: 372 GHDMELRSYGIGAQILADLGVHDMVLLTNSHHNLVALEGYGLSIVGEQAIP 422


>UniRef50_Q1QUC7 GTP cyclohydrolase II n=69 Tax=cellular organisms
           RepID=Q1QUC7_CHRSD
          Length = 386

 Score =  106 bits (265), Expect = 5e-22,   Method: Composition-based stats.
 Identities = 39/177 (22%), Positives = 73/177 (41%), Gaps = 6/177 (3%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           +  V  + + T +G+  +  F +      H+ALV G     +P   RVH      D L  
Sbjct: 212 VDEVERSVVDTAFGELTLHVFRDRIQNTHHLALVKGTPRTESPTTVRVHIADTLRDLLML 271

Query: 63  LRCD-CGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
            R D   +   +AL QIA+   G+ +        + L +++     +     + E++   
Sbjct: 272 TRPDSHSWTAASALAQIADAEAGVFVLLDDGRPRLDLKDQLDVLLGRKPAPRSSESD--- 328

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPN 178
             A +       + + + LGV ++RLL+ +P K   L+   + +VERV      +  
Sbjct: 329 -GAGNYLTIGTGSQILRQLGVGQMRLLS-SPWKFSALSGFDLEVVERVGGDTPESDQ 383


>UniRef50_C1HDW1 GTP cyclohydrolase-2 n=2 Tax=Onygenales RepID=C1HDW1_PARBA
          Length = 500

 Score =  104 bits (259), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 36/155 (23%), Positives = 59/155 (38%), Gaps = 46/155 (29%)

Query: 36  VYGDISGHTPVLAR----VHSECLTGDALFSLRCDCGFQL----EAALTQIAEEGRGILL 87
            +GD +  +    R    VH EC   D   S  C C   L    E A+ +    G G+++
Sbjct: 346 CFGDPAKMSDPSVRLALRVHDECNGSDVFGSDICTCRPYLIFGIEEAVKEAQRGGSGVVI 405

Query: 88  YHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNEV-R 146
           Y R+EGR +G                                     ++   LG+ ++ R
Sbjct: 406 YFRKEGRALG-------------------------------------EILHWLGITKIDR 428

Query: 147 LLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181
           +L+ +  K + + E GI I+ERVP+     P +  
Sbjct: 429 MLSMSNMKHDAIVEQGIPILERVPIPDELIPEDSR 463


>UniRef50_Q59AD7 GTP cyclohydrolase-2 (Fragment) n=2 Tax=Buchnera aphidicola
          RepID=Q59AD7_9ENTR
          Length = 81

 Score = 99.9 bits (248), Expect = 4e-20,   Method: Composition-based stats.
 Identities = 43/81 (53%), Positives = 61/81 (75%), Gaps = 6/81 (7%)

Query: 16 GDFLMVGFEE--LATGHDHVALVYGDIS----GHTPVLARVHSECLTGDALFSLRCDCGF 69
          G+F ++GFEE       +HVAL+YG+I+     +  VL R+HSECLTGDALFSLRCDCGF
Sbjct: 1  GEFTLIGFEEISKLEKKNHVALIYGNINLLILKNKAVLVRIHSECLTGDALFSLRCDCGF 60

Query: 70 QLEAALTQIAEEGRGILLYHR 90
          QL+ ++  I+++G G+++YHR
Sbjct: 61 QLKQSMKIISKKGFGVIIYHR 81


>UniRef50_UPI0001BCED67 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP
           cyclohydrolase II protein n=1 Tax=Campylobacter fetus
           subsp. venerealis str. Azul-94 RepID=UPI0001BCED67
          Length = 169

 Score = 96.4 bits (239), Expect = 4e-19,   Method: Composition-based stats.
 Identities = 30/90 (33%), Positives = 44/90 (48%), Gaps = 1/90 (1%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           ++R  E   PT +G+F  + + E+ T  +HVALV GDIS     L RV +  + GD   +
Sbjct: 69  IEREIEKPFPTNYGEFRAIIYREVLTEQEHVALVKGDISSGAA-LVRVQAGNVFGDIFNA 127

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQE 92
              D    +  A+ QI    +   LY R E
Sbjct: 128 SGLDGAKIIAGAMQQIERAEKEFFLYMRHE 157


>UniRef50_C0XBJ0 GTP cyclohydrolase-2 n=3 Tax=Lactobacillus gasseri
           RepID=C0XBJ0_9LACO
          Length = 96

 Score = 91.0 bits (225), Expect = 2e-17,   Method: Composition-based stats.
 Identities = 32/88 (36%), Positives = 45/88 (51%), Gaps = 5/88 (5%)

Query: 113 DTVEANHQLGFAADERDFT-----LCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVE 167
           D    N  L  A   R  T     + A + K L + E+ LLTNNP K++ L + GI I +
Sbjct: 4   DQYYMNLALQEAKKGRFQTWKNPLVGAVIVKELKIKEINLLTNNPDKIDQLNDYGIKINK 63

Query: 168 RVPLIVGRNPNNEHYLDTKAEKMGHLLN 195
           R+PL +  N  +  YL TK ++  HLL 
Sbjct: 64  RIPLEIAPNDVDRFYLQTKKKRFHHLLE 91


>UniRef50_Q0G5B3 GTP CYCLOHYDROLASE II / 3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE
           SYNTHASE n=1 Tax=Fulvimarina pelagi HTCC2506
           RepID=Q0G5B3_9RHIZ
          Length = 375

 Score = 88.7 bits (219), Expect = 1e-16,   Method: Composition-based stats.
 Identities = 32/154 (20%), Positives = 59/154 (38%), Gaps = 12/154 (7%)

Query: 19  LMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQI 78
            +  +E       HV  V+GD+     V  R+H E    D     R D    +E A+ +I
Sbjct: 227 QIRIYETPFDDLQHVVAVFGDVREGEGVPVRIHREQPVTDLFGRTR-DTKTWVEIAVDEI 285

Query: 79  AEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANH---QLGFAADERDFTLCAD 135
            + G G+L+  R          ++  + L D   D  +       +      R+  L A 
Sbjct: 286 GKLGHGVLMLLRTP--------EVDEFDLGDTVIDHADGEKHQSAISRRKRWREVGLGAQ 337

Query: 136 MFKLLGVNEVRLLTNNPKKVEILTEAGINIVERV 169
           + + L +  +R + ++ +    LT  GI +   +
Sbjct: 338 ILRDLQIRSIREIASHERAYVGLTGFGIEVTGTI 371


>UniRef50_UPI0001850D2C bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP
           cyclohydrolase II protein n=1 Tax=Bacillus coahuilensis
           m4-4 RepID=UPI0001850D2C
          Length = 187

 Score = 86.0 bits (212), Expect = 6e-16,   Method: Composition-based stats.
 Identities = 30/155 (19%), Positives = 67/155 (43%), Gaps = 24/155 (15%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           +++ +E +L      F ++ ++++ TG +H+AL+ G  S       RVH+E L  +    
Sbjct: 57  IEKTSEQRLVIQGDTFELITYQDIFTGLEHLALIKGKPS-DETTYVRVHAESLIKELTGD 115

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
                   ++  + Q+  +  G+ LY R            +    Q        +  +LG
Sbjct: 116 ------SSVKQGIEQMKNKEHGVFLYIR----------STKTIHEQI-------SEEELG 152

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEI 157
                +D+ + A + + +G+ ++  +T++PKK   
Sbjct: 153 EDESLKDYGIGAQILQDIGIKKMIWITDHPKKYPA 187


>UniRef50_UPI0001C31D71 34-dihydroxy-2-butanone 4-phosphate synthase n=1 Tax=Conexibacter
           woesei DSM 14684 RepID=UPI0001C31D71
          Length = 344

 Score = 80.6 bits (198), Expect = 2e-14,   Method: Composition-based stats.
 Identities = 43/144 (29%), Positives = 62/144 (43%), Gaps = 19/144 (13%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLAR-VHSECLTGDALF 61
           ++RV E  LP P G F  +G+E  A   DHVAL  GD +   P   R VH  C  G+AL 
Sbjct: 216 VRRVVETALPLPAGPFRAIGYESAAGAADHVALALGDPAA--PGAPRFVHLRC-GGEALG 272

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
              C C  +L++AL +IA  G G+L     E R         +   Q +   +       
Sbjct: 273 --LCGCRARLDSALAEIAAAGDGVLAVLAGEDR--------PSITTQPRCATSASPQELP 322

Query: 122 GFAADERDFTLCADMFKLLGVNEV 145
              A      +   +F  LG+ ++
Sbjct: 323 RLLA-----GIARSIFGDLGIRDL 341


>UniRef50_Q1UZ97 GTP cyclohydrolase II /3,4-dihydroxy-2-butanone 4-phosphatesynthase
           n=4 Tax=SAR11 cluster RepID=Q1UZ97_PELUB
          Length = 366

 Score = 72.9 bits (178), Expect = 6e-12,   Method: Composition-based stats.
 Identities = 29/162 (17%), Positives = 63/162 (38%), Gaps = 11/162 (6%)

Query: 8   EAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDC 67
           ++ +      + +  +E L  G +H AL+ G+I        RV S  +  + L + +   
Sbjct: 214 QSDIKVKNQKYKIRIYENLLDGSEHFALIKGNIKKGIIPRVRVISSNVVQNYLINQQLP- 272

Query: 68  GFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADE 127
               +  L    +    +L++     ++  L +  +            + N +L      
Sbjct: 273 -NSFDKTLNYFKKFNNCVLVFI----KDTNLKSVTQTLKDYKNKNFYKKGNDKL-----I 322

Query: 128 RDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERV 169
           R++ + A + K L +  + L+T + KKV  L    I I ++ 
Sbjct: 323 RNYGIGAQIIKDLKIKNMILITKSLKKVIGLEGYDIKITKQE 364


>UniRef50_Q0E2P5 Os02g0223200 protein (Fragment) n=2 Tax=Oryza sativa Japonica Group
           RepID=Q0E2P5_ORYSJ
          Length = 157

 Score = 61.4 bits (148), Expect = 2e-08,   Method: Composition-based stats.
 Identities = 22/68 (32%), Positives = 31/68 (45%), Gaps = 16/68 (23%)

Query: 103 RAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAG 162
           R Y L D G+DTV+AN +LG A D R++ + A +                 K   L    
Sbjct: 69  RTYNLLDDGHDTVQANVELGLAVDSREYGIGAQV----------------AKFVGLKGYR 112

Query: 163 INIVERVP 170
           + +V RVP
Sbjct: 113 LAVVGRVP 120


>UniRef50_Q9APK4 GTP cyclohydrolase-2 (Fragment) n=1 Tax=Hyphomicrobium
          chloromethanicum RepID=Q9APK4_9RHIZ
          Length = 68

 Score = 57.5 bits (138), Expect = 2e-07,   Method: Composition-based stats.
 Identities = 18/56 (32%), Positives = 27/56 (48%), Gaps = 2/56 (3%)

Query: 18 FLMVGFEELATGHDHVALVYG--DISGHTPVLARVHSECLTGDALFSLRCDCGFQL 71
          F    F       + + L++    I+  +  L  +HS CL GDA  S+RCDC  +L
Sbjct: 13 FEARAFLGPTEDEEALVLIHQQVPIAPDSEPLVYIHSGCLVGDAFHSMRCDCRRRL 68


>UniRef50_Q9PHU4 3,4-dihydroxy-2-butanone 4-phosphate synthase n=14
           Tax=Campylobacter RepID=RIBB_CAMJE
          Length = 339

 Score = 55.2 bits (132), Expect = 1e-06,   Method: Composition-based stats.
 Identities = 26/152 (17%), Positives = 51/152 (33%), Gaps = 42/152 (27%)

Query: 18  FLMVGFEELATGH-DHVALVYGDISGHTPVLARV---HSECLTGDALFSLRCDCGFQLEA 73
           F    F         H+A  + DI     V   +     E LT D           +L  
Sbjct: 218 FKAEKFIFSDHNQTQHIAFCFKDIKKCENVKFHISGSDFELLTSDKF--------SKLLE 269

Query: 74  ALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLC 133
            +  ++E G G++++                   Q +   T +           +++ + 
Sbjct: 270 QIKFLSENG-GVIVFM------------------QGEKSSTTQ----------YKNYGIG 300

Query: 134 ADMFKLLGVNEVRLLTNNPKK-VEILTEAGIN 164
           A + +  G+ E++LL+ +  K    L   G+N
Sbjct: 301 AQILRYFGIEEIKLLSQSCDKDYIGLEGFGLN 332


>UniRef50_B7FLV1 Putative uncharacterized protein n=1 Tax=Medicago truncatula
           RepID=B7FLV1_MEDTR
          Length = 231

 Score = 54.4 bits (130), Expect = 2e-06,   Method: Composition-based stats.
 Identities = 15/41 (36%), Positives = 22/41 (53%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGH 43
           ++R   A +PT WG F    +  L  G +H+A+V GDI   
Sbjct: 190 VERAGAALIPTMWGPFEANCYRSLLDGMEHIAMVKGDIGDG 230


>UniRef50_A8HP30 Bifunctional GTP cyclohydrolase (Fragment) n=3 Tax=Eukaryota
           RepID=A8HP30_CHLRE
          Length = 390

 Score = 54.0 bits (129), Expect = 3e-06,   Method: Composition-based stats.
 Identities = 38/163 (23%), Positives = 57/163 (34%), Gaps = 23/163 (14%)

Query: 19  LMVGFEELATGHDHVALVYGDI-SGHTPVLARVHSECLTGDALFSLRC--------DC-- 67
               F     G +HVA V+G +    + VL  VH E    D L             DC  
Sbjct: 235 TAQAFRNAVDGTEHVAFVHGAVADSASDVLLHVHHERTVADLLDCAAPGTSAGGAADCSL 294

Query: 68  ----GFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
                  L+ AL  +A  G G+++Y R Q  R +           +     +  A     
Sbjct: 295 PAANASSLDGALRSVAAAGAGVVVYLRGQSARGLPPSA-------ELAALGSGGAGAGAL 347

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINI 165
           ++ D +D  + A M + LGV  V L          L   G+ +
Sbjct: 348 YSCDLKDAAVVAQMLRQLGVRSVSLAGGEGAMATALRSCGLAV 390


>UniRef50_Q2GW54 Putative uncharacterized protein n=1 Tax=Chaetomium globosum
           RepID=Q2GW54_CHAGB
          Length = 480

 Score = 53.7 bits (128), Expect = 3e-06,   Method: Composition-based stats.
 Identities = 17/79 (21%), Positives = 29/79 (36%), Gaps = 8/79 (10%)

Query: 102 IRAYALQDQGYDT----VEANHQLGFAADERDFTLCADMFKLLGVNEV-RLLTNNPKKVE 156
              Y  + +G D      +    +    D R   L  D+   LG+ ++ R+L+ +     
Sbjct: 340 YLVYNARKRGEDRASDYFKRTENIAGVKDMRFQALMPDILHWLGITKIDRMLSMSNSSET 399

Query: 157 ILTE---AGINIVERVPLI 172
              +     I I ERV L 
Sbjct: 400 GNADGPSHSIPIHERVELP 418


>UniRef50_C7MUB0 3,4-dihydroxy-2-butanone 4-phosphate synthase n=1
           Tax=Saccharomonospora viridis DSM 43017
           RepID=C7MUB0_SACVD
          Length = 403

 Score = 53.7 bits (128), Expect = 4e-06,   Method: Composition-based stats.
 Identities = 16/49 (32%), Positives = 28/49 (57%), Gaps = 1/49 (2%)

Query: 2   QLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARV 50
           ++ R+A  +LPT  G+   +G+ +  TG +H+AL  G+ +  T  L  V
Sbjct: 233 RVTRMAHTRLPTRHGELRAIGYRDDVTGAEHLAL-LGEPTPGTYPLVAV 280


>UniRef50_UPI0001B53FE8 hypothetical protein StAA4_17215 n=1 Tax=Streptomyces sp. AA4
           RepID=UPI0001B53FE8
          Length = 83

 Score = 52.1 bits (124), Expect = 1e-05,   Method: Composition-based stats.
 Identities = 15/37 (40%), Positives = 23/37 (62%)

Query: 120 QLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVE 156
           +LG  AD R++   A +   LGV+  ++LTNNP K+ 
Sbjct: 38  RLGEPADAREYGAAAAILLDLGVSRAQVLTNNPGKLR 74


>UniRef50_Q9ZL40 3,4-dihydroxy-2-butanone 4-phosphate synthase n=23
           Tax=Epsilonproteobacteria RepID=RIBB_HELPJ
          Length = 344

 Score = 51.7 bits (123), Expect = 1e-05,   Method: Composition-based stats.
 Identities = 29/156 (18%), Positives = 51/156 (32%), Gaps = 35/156 (22%)

Query: 19  LMVGFEELATGH-DHVAL-VYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALT 76
               +  L     +H A    G  +     L R H      +    L          AL 
Sbjct: 221 QTQCYTFLDHQQKNHYAFKFKGAKTHDLAPLVRFH---PIKEDFDFLTTGAFEAFFKALE 277

Query: 77  QIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADM 136
            +  EG G L++         ++                            +DF + A +
Sbjct: 278 YLKREG-GYLIFMNTHSEQNNIV----------------------------KDFGIGALV 308

Query: 137 FKLLGVNEVRLLTN-NPKKVEILTEAGINIVERVPL 171
            K LGV + RLL++   ++ + L+  G+ +VE + L
Sbjct: 309 LKNLGVKDFRLLSSCEDRQYKALSGFGLKLVETISL 344


>UniRef50_O68249 3,4-dihydroxy-2-butanone 4-phosphate synthase n=18
           Tax=Epsilonproteobacteria RepID=RIBB_DEHMU
          Length = 356

 Score = 51.0 bits (121), Expect = 2e-05,   Method: Composition-based stats.
 Identities = 30/168 (17%), Positives = 67/168 (39%), Gaps = 39/168 (23%)

Query: 3   LKRVAEAKLPTPW-G-DFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDAL 60
           ++ +AE+   T + G D     F +    H H+A  +G+I   +    + HS     + L
Sbjct: 216 IRVIAEST--TQFLGKDARRYDFVDHNDNH-HIAYAFGNIKNRSA--VKFHSIMPDNELL 270

Query: 61  FSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQ 120
              +      L  A+  + + G G+L++          ++KI                  
Sbjct: 271 ADTKK--YNSLIQAIHYLQKSG-GVLIFMDN---GTQDMSKI------------------ 306

Query: 121 LGFAADERDFTLCADMFKLLGVNEVRLLTNNPKK-VEILTEAGINIVE 167
                  R++ + A + K LG+  + LL+++  K    ++  G+++++
Sbjct: 307 -------REYGIGAQIIKHLGIENIELLSDSKNKEFVGISGFGLSVIK 347


>UniRef50_D0NPB4 Riboflavin biosynthesis protein ribBA, putative n=2
           Tax=Phytophthora infestans T30-4 RepID=D0NPB4_PHYIN
          Length = 329

 Score = 44.4 bits (104), Expect = 0.002,   Method: Composition-based stats.
 Identities = 27/89 (30%), Positives = 42/89 (47%), Gaps = 13/89 (14%)

Query: 3   LKRVAE-AKLPTPWGDFLMVGFEELA-TGHDHVALVYGDISGHTPVLARVHSECLTGDAL 60
           ++R+ E +K+ TP G+F  V ++ L      + ALVYGD+ G   VL       L  D  
Sbjct: 220 VQRIDEQSKVTTPLGEFASVAYKSLVQENQTYHALVYGDVDGKD-VLV-----FLVEDGF 273

Query: 61  FSLRCDCGFQLEAALTQIAEEGRGILLYH 89
                +   Q + A   +A  G G+L+Y 
Sbjct: 274 -----EASLQAQWAQKFVATHGYGVLIYI 297


>UniRef50_UPI0001699144 3,4-dihydroxy-2-butanone 4-phosphate synthase / GTP
          cyclohydrolase II n=1 Tax=Endoriftia persephone
          'Hot96_1+Hot96_2' RepID=UPI0001699144
          Length = 60

 Score = 40.2 bits (93), Expect = 0.037,   Method: Composition-based stats.
 Identities = 10/26 (38%), Positives = 17/26 (65%)

Query: 66 DCGFQLEAALTQIAEEGRGILLYHRQ 91
          DCG+ L  A+ Q++E G G+++  R 
Sbjct: 10 DCGWPLANAMKQVSEAGEGVIVVLRN 35


Searching..................................................done


Results from round 3


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value
Sequences used in model and found again:

UniRef50_C5D3N0 GTP cyclohydrolase-2 n=25 Tax=cellular organisms...   311   8e-84
UniRef50_C9M9Y1 3,4-dihydroxy-2-butanone 4-phosphate synthase/GT...   297   1e-79
UniRef50_P74104 GTP cyclohydrolase-2 n=580 Tax=cellular organism...   296   3e-79
UniRef50_D1IKX7 Whole genome shotgun sequence of line PN40024, s...   295   8e-79
UniRef50_B9HF78 Predicted protein (Fragment) n=10 Tax=cellular o...   292   5e-78
UniRef50_Q11WK6 GTP cyclohydrolase-2 n=44 Tax=Bacteria RepID=RIB...   290   1e-77
UniRef50_A6T7Y5 GTP cyclohydrolase-2 n=139 Tax=cellular organism...   289   3e-77
UniRef50_C4Z7I1 GTP cyclohydrolase II / 3,4-dihydroxy 2-butanone...   289   4e-77
UniRef50_A4VHT9 GTP cyclohydrolase-2 n=5 Tax=Proteobacteria RepI...   289   4e-77
UniRef50_P47924 GTP cyclohydrolase-2 n=36 Tax=cellular organisms...   288   9e-77
UniRef50_Q2SA07 GTP cyclohydrolase-2 n=16 Tax=Bacteria RepID=RIB...   285   5e-76
UniRef50_A0PPL6 GTP cyclohydrolase-2 n=82 Tax=Bacteria RepID=RIB...   285   6e-76
UniRef50_A1T8K1 GTP cyclohydrolase-2 n=43 Tax=cellular organisms...   285   7e-76
UniRef50_O84736 GTP cyclohydrolase-2 n=38 Tax=Bacteria RepID=RIB...   285   8e-76
UniRef50_Q65SC0 GTP cyclohydrolase-2 n=55 Tax=Bacteria RepID=RIB...   281   1e-74
UniRef50_C9KJZ5 3,4-dihydroxy-2-butanone 4-phosphate synthase/GT...   279   3e-74
UniRef50_Q4QNX8 GTP cyclohydrolase-2 n=78 Tax=cellular organisms...   279   4e-74
UniRef50_Q5F7N6 GTP cyclohydrolase-2 n=33 Tax=Bacteria RepID=RIB...   277   2e-73
UniRef50_C4GH90 GTP cyclohydrolase-2 n=1 Tax=Kingella oralis ATC...   277   2e-73
UniRef50_C0VNE9 GTP cyclohydrolase-2 n=2 Tax=Moraxellaceae RepID...   276   3e-73
UniRef50_Q13NP8 GTP cyclohydrolase-2 n=9 Tax=cellular organisms ...   275   5e-73
UniRef50_P57863 GTP cyclohydrolase-2 n=17 Tax=Proteobacteria Rep...   275   7e-73
UniRef50_C5CJ14 GTP cyclohydrolase II n=1 Tax=Kosmotoga olearia ...   274   1e-72
UniRef50_C8WEC3 GTP cyclohydrolase-2 n=10 Tax=Sphingomonadales R...   269   4e-71
UniRef50_D2RDK3 GTP cyclohydrolase II n=2 Tax=Archaeoglobaceae R...   268   9e-71
UniRef50_D2R1R5 GTP cyclohydrolase II n=3 Tax=Planctomycetaceae ...   267   2e-70
UniRef50_D1BH22 GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4...   265   6e-70
UniRef50_UPI0001905AE1 GTP cyclohydrolase II protein n=1 Tax=Rhi...   264   9e-70
UniRef50_Q1D4N5 GTP cyclohydrolase-2 n=6 Tax=Cystobacterineae Re...   263   2e-69
UniRef50_B8JBX2 GTP cyclohydrolase-2 n=5 Tax=Bacteria RepID=B8JB...   262   4e-69
UniRef50_Q9X2E6 GTP cyclohydrolase-2 n=13 Tax=cellular organisms...   261   9e-69
UniRef50_O29766 GTP cyclohydrolase-2 n=1 Tax=Archaeoglobus fulgi...   259   3e-68
UniRef50_D0LLG6 GTP cyclohydrolase-2 n=1 Tax=Haliangium ochraceu...   259   5e-68
UniRef50_B0RC63 Riboflavin biosynthesis protein RibA n=7 Tax=Act...   258   7e-68
UniRef50_Q4L7B1 GTP cyclohydrolase-2 n=3 Tax=Staphylococcus RepI...   257   2e-67
UniRef50_Q6GFT5 GTP cyclohydrolase-2 n=76 Tax=Bacteria RepID=RIB...   257   2e-67
UniRef50_P43525 GTP cyclohydrolase-2 n=6 Tax=Alphaproteobacteria...   257   2e-67
UniRef50_A6C5C2 Riboflavin biosynthesis protein RibA n=1 Tax=Pla...   255   5e-67
UniRef50_Q1GKN3 GTP cyclohydrolase-2 n=44 Tax=Rhodobacterales Re...   255   5e-67
UniRef50_A8IZV5 Bifunctional GTP cyclohydrolase II n=1 Tax=Chlam...   254   1e-66
UniRef50_Q4FV65 GTP cyclohydrolase-2 n=3 Tax=Psychrobacter RepID...   254   1e-66
UniRef50_C0YM11 GTP cyclohydrolase-2 n=2 Tax=Chryseobacterium gl...   252   4e-66
UniRef50_Q1IPQ1 GTP cyclohydrolase-2 n=4 Tax=Bacteria RepID=Q1IP...   252   6e-66
UniRef50_C9MTM9 GTP cyclohydrolase-2 n=1 Tax=Prevotella verorali...   252   6e-66
UniRef50_UPI000050F87F bifunctional 3,4-dihydroxy-2-butanone 4-p...   250   2e-65
UniRef50_A0JVK1 GTP cyclohydrolase-2 n=2 Tax=Micrococcaceae RepI...   249   3e-65
UniRef50_A9FWS8 GTP cyclohydrolase-2 n=1 Tax=Sorangium cellulosu...   248   8e-65
UniRef50_C1E155 Predicted protein n=2 Tax=Micromonas RepID=C1E15...   247   2e-64
UniRef50_C7JCF3 Bifunctional protein 3,4-dihydroxy-2-butanone 4-...   246   2e-64
UniRef50_A4XHM6 GTP cyclohydrolase II n=2 Tax=Clostridia RepID=A...   246   3e-64
UniRef50_A7I3X0 GTP cyclohydrolase-2 n=6 Tax=cellular organisms ...   246   3e-64
UniRef50_A0RR75 GTP cyclohydrolase-2 n=10 Tax=Epsilonproteobacte...   246   3e-64
UniRef50_B8H6T8 GTP cyclohydrolase-2 n=1 Tax=Arthrobacter chloro...   246   4e-64
UniRef50_A4RYG5 Predicted protein n=1 Tax=Ostreococcus lucimarin...   245   5e-64
UniRef50_B9L8K1 GTP cyclohydrolase-2 n=3 Tax=Bacteria RepID=B9L8...   245   6e-64
UniRef50_C6V5M6 GTP cyclohydrolase-2 n=2 Tax=Neorickettsia RepID...   244   1e-63
UniRef50_A5G2C3 GTP cyclohydrolase-2 n=2 Tax=Rhodospirillales Re...   243   2e-63
UniRef50_Q17XC9 GTP cyclohydrolase-2 n=13 Tax=Helicobacter RepID...   243   2e-63
UniRef50_D0NCB5 Riboflavin biosynthesis protein ribBA, putative ...   243   3e-63
UniRef50_B7IF97 A 3,4-dihydroxy-2-butanone 4-phosphate synthase/...   242   4e-63
UniRef50_Q83FM7 GTP cyclohydrolase-2 n=2 Tax=Tropheryma whipplei...   240   2e-62
UniRef50_C7NTK7 GTP cyclohydrolase II n=1 Tax=Halorhabdus utahen...   238   5e-62
UniRef50_A6G7P6 GTP cyclohydrolase-2 n=1 Tax=Plesiocystis pacifi...   238   6e-62
UniRef50_Q1QYD0 GTP cyclohydrolase-2 n=1 Tax=Chromohalobacter sa...   238   6e-62
UniRef50_C6X006 GTP cyclohydrolase-2 n=1 Tax=Flavobacteriaceae b...   238   9e-62
UniRef50_B9ZQZ7 GTP cyclohydrolase-2 n=1 Tax=Thioalkalivibrio sp...   237   2e-61
UniRef50_Q604R2 Riboflavin-specific deaminase/GTP cyclohydrolase...   237   2e-61
UniRef50_A6W477 GTP cyclohydrolase-2 n=8 Tax=Bacteria RepID=A6W4...   236   4e-61
UniRef50_C4K9I6 GTP cyclohydrolase-2 n=1 Tax=Thauera sp. MZ1T Re...   235   5e-61
UniRef50_A6VWW9 GTP cyclohydrolase-2 n=47 Tax=Bacteria RepID=RIB...   235   5e-61
UniRef50_UPI000051036D riboflavin-specific deaminase/GTP cyclohy...   235   7e-61
UniRef50_D2LG53 GTP cyclohydrolase II n=1 Tax=Rhodomicrobium van...   235   7e-61
UniRef50_Q7VK48 GTP cyclohydrolase-2 n=2 Tax=Helicobacteraceae R...   235   9e-61
UniRef50_A6DFW0 GTP cyclohydrolase-2 n=1 Tax=Lentisphaera araneo...   233   2e-60
UniRef50_B2GGU5 GTP cyclohydrolase-2 n=1 Tax=Kocuria rhizophila ...   233   3e-60
UniRef50_D2NTM1 GTP cyclohydrolase II n=2 Tax=Rothia mucilaginos...   233   4e-60
UniRef50_A1SSA8 GTP cyclohydrolase-2 n=10 Tax=Gammaproteobacteri...   232   7e-60
UniRef50_Q03XZ0 GTP cyclohydrolase II n=1 Tax=Leuconostoc mesent...   229   4e-59
UniRef50_B3CNI0 GTP cyclohydrolase-2 n=13 Tax=Wolbachia RepID=B3...   228   8e-59
UniRef50_C7R1D1 3,4-dihydroxy-2-butanone 4-phosphate synthase n=...   227   2e-58
UniRef50_C6QGG9 GTP cyclohydrolase-2 n=1 Tax=Hyphomicrobium deni...   227   2e-58
UniRef50_A5ARE3 Putative uncharacterized protein n=1 Tax=Vitis v...   224   1e-57
UniRef50_Q87D69 GTP cyclohydrolase-2 n=22 Tax=Proteobacteria Rep...   222   5e-57
UniRef50_Q4V1U4 GTP cyclohydrolase-2 n=26 Tax=Bacillus cereus gr...   213   2e-54
UniRef50_P51618 GTP cyclohydrolase-2 n=63 Tax=Gammaproteobacteri...   213   3e-54
UniRef50_A8FIW0 GTP cyclohydrolase-2 n=7 Tax=Bacillales RepID=A8...   213   4e-54
UniRef50_Q3YT81 GTP cyclohydrolase-2 n=6 Tax=canis group RepID=Q...   212   5e-54
UniRef50_C5AMM6 GTP cyclohydrolase-2 n=2 Tax=Burkholderia glumae...   212   7e-54
UniRef50_C9S9H3 GTP cyclohydrolase-2 n=1 Tax=Verticillium albo-a...   210   2e-53
UniRef50_B9KHB1 GTP cyclohydrolase-2 n=5 Tax=Anaplasma RepID=B9K...   209   5e-53
UniRef50_B0UFT4 GTP cyclohydrolase-2 n=4 Tax=Rhizobiales RepID=B...   208   9e-53
UniRef50_Q14FW6 Riboflavin biosynthesis protein ribA/GTP-cyclohy...   208   1e-52
UniRef50_P50139 GTP cyclohydrolase-2 n=33 Tax=Ascomycota RepID=R...   205   7e-52
UniRef50_B8KSW9 GTP cyclohydrolase-2 n=1 Tax=gamma proteobacteri...   201   9e-51
UniRef50_A8NX34 GTP cyclohydrolase-2 n=2 Tax=Agaricales RepID=A8...   200   2e-50
UniRef50_P38066 GTP cyclohydrolase-2 n=8 Tax=Saccharomycetales R...   199   5e-50
UniRef50_A0Z3E0 GTP cyclohydrolase-2 n=1 Tax=marine gamma proteo...   196   2e-49
UniRef50_C9PF77 GTP cyclohydrolase II n=1 Tax=Vibrio furnissii C...   196   3e-49
UniRef50_C5LSF0 GTP cyclohydrolase II, putative (Fragment) n=1 T...   196   4e-49
UniRef50_C0A9J6 GTP cyclohydrolase-2 n=1 Tax=Opitutaceae bacteri...   195   7e-49
UniRef50_Q5KNS2 GTP cyclohydrolase-2 n=1 Tax=Filobasidiella neof...   193   3e-48
UniRef50_A6MYZ0 GTP cyclohydrolase-2 n=2 Tax=Saccharomycetaceae ...   193   4e-48
UniRef50_Q4P4Y7 GTP cyclohydrolase-2 n=2 Tax=Basidiomycota RepID...   192   5e-48
UniRef50_A8FAX3 GTP cyclohydrolase-2 n=2 Tax=Bacillus pumilus Re...   191   9e-48
UniRef50_D0L7U8 3,4-dihydroxy-2-butanone 4-phosphate synthase n=...   190   2e-47
UniRef50_Q2S6L1 3,4-dihydroxy-2-butanone 4-phosphate synthase/GT...   188   8e-47
UniRef50_A1SF04 GTP cyclohydrolase-2 n=16 Tax=Bacteria RepID=A1S...   186   5e-46
UniRef50_A8PZB1 GTP cyclohydrolase-2 n=1 Tax=Malassezia globosa ...   178   7e-44
UniRef50_C5RMY3 GTP cyclohydrolase-2 n=1 Tax=Clostridium cellulo...   177   2e-43
UniRef50_Q0D0K3 GTP cyclohydrolase-2 n=29 Tax=Leotiomyceta RepID...   176   4e-43
UniRef50_A0SNY3 Riboflavin biosynthesis protein RibA n=2 Tax=Can...   173   2e-42
UniRef50_Q5YVN1 GTP cyclohydrolase-2 n=1 Tax=Nocardia farcinica ...   173   3e-42
UniRef50_Q6KH48 GTP cyclohydrolase-2 n=1 Tax=Mycoplasma mobile R...   166   5e-40
UniRef50_Q08VV8 GTP cyclohydrolase-2 n=1 Tax=Stigmatella auranti...   163   3e-39
UniRef50_A2TRN2 GTP cyclohydrolase-2 n=1 Tax=Dokdonia donghaensi...   159   4e-38
UniRef50_A9QS81 GTP cyclohydrolase-2 n=1 Tax=Lactococcus lactis ...   155   7e-37
UniRef50_B5JMM0 3,4-dihydroxy-2-butanone 4-phosphate synthase fa...   145   6e-34
UniRef50_C0YN89 3,4-dihydroxy-2-butanone-4-phosphate synthase n=...   145   8e-34
UniRef50_Q6MIV8 GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone...   144   1e-33
UniRef50_A0SNY4 Riboflavin biosynthesis protein RibA n=2 Tax=Can...   144   2e-33
UniRef50_A6DFW1 3,4-dihydroxy-2-butanone 4-phosphate synthase/GT...   143   2e-33
UniRef50_C5FIC6 GTP cyclohydrolase-2 n=1 Tax=Microsporum canis C...   141   1e-32
UniRef50_A0M3F6 Riboflavin biosynthesis protein n=17 Tax=Bactero...   141   2e-32
UniRef50_A7IMW5 3,4-dihydroxy-2-butanone 4-phosphate synthase n=...   139   7e-32
UniRef50_C6X067 3,4-dihydroxy-2-butanone 4-phosphate synthase / ...   138   1e-31
UniRef50_Q9R6K1 GTP cyclohydrolase-2 n=1 Tax=Agrobacterium tumef...   137   2e-31
UniRef50_Q882G0 3,4-dihydroxy-2-butanone 4-phosphate synthase n=...   136   3e-31
UniRef50_Q2NZ90 3,4-dihydroxy-2-butanone 4-phosphate synthase n=...   134   1e-30
UniRef50_D1ZD95 GTP cyclohydrolase-2 n=1 Tax=Sordaria macrospora...   132   8e-30
UniRef50_Q1DG18 GTP cyclohydrolase-2 n=2 Tax=Bacteria RepID=Q1DG...   131   9e-30
UniRef50_B7FNY5 Predicted protein n=1 Tax=Phaeodactylum tricornu...   130   2e-29
UniRef50_Q9US41 Uracil-regulated protein 1 n=101 Tax=cellular or...   129   5e-29
UniRef50_Q1QUC7 GTP cyclohydrolase II n=69 Tax=cellular organism...   129   6e-29
UniRef50_B4RM34 3,4-dihydroxy-2-butanone 4-phosphate synthase n=...   129   7e-29
UniRef50_Q5K843 GTP cyclohydrolase-2 n=5 Tax=Eukaryota RepID=Q5K...   129   7e-29
UniRef50_D2UG04 Putative gtp cyclohydrolase II 3, 4-dihydroxy-2-...   127   2e-28
UniRef50_D0NXG3 Putative uncharacterized protein n=1 Tax=Phytoph...   126   5e-28
UniRef50_Q1AZ21 GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone...   125   1e-27
UniRef50_A6G9U6 3,4-dihydroxy-2-butanone 4-phosphate synthase/GT...   123   4e-27
UniRef50_A4A6E4 Riboflavin biosynthesis protein ribA n=5 Tax=unc...   122   4e-27
UniRef50_Q2G801 GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone...   122   5e-27
UniRef50_Q1GEQ5 GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone...   121   1e-26
UniRef50_A8PF74 GTP cyclohydrolase-2 n=1 Tax=Coprinopsis cinerea...   118   9e-26
UniRef50_B2AIS6 RIBOFLAVIN BIOSYNTHESIS BIFUNCTIONAL PROTEIN : G...   117   2e-25
UniRef50_A4JQ12 GTP cyclohydrolase II n=9 Tax=Proteobacteria Rep...   117   3e-25
UniRef50_A6RZS8 GTP cyclohydrolase-2 n=1 Tax=Botryotinia fuckeli...   116   6e-25
UniRef50_Q1AV39 GTP cyclohydrolase-2 n=1 Tax=Rubrobacter xylanop...   114   2e-24
UniRef50_C1HDW1 GTP cyclohydrolase-2 n=2 Tax=Onygenales RepID=C1...   111   2e-23
UniRef50_Q0G5B3 GTP CYCLOHYDROLASE II / 3,4-DIHYDROXY-2-BUTANONE...   110   3e-23
UniRef50_D0LW49 3,4-dihydroxy-2-butanone 4-phosphate synthase n=...   109   4e-23
UniRef50_A0PS46 Riboflavin biosynthesis protein RibA1 n=16 Tax=C...   104   2e-21
UniRef50_Q1UZ97 GTP cyclohydrolase II /3,4-dihydroxy-2-butanone ...   101   1e-20
UniRef50_C0XBJ0 GTP cyclohydrolase-2 n=3 Tax=Lactobacillus gasse...    97   2e-19
UniRef50_UPI0001850D2C bifunctional 3,4-dihydroxy-2-butanone 4-p...    97   3e-19
UniRef50_UPI0001BCED67 bifunctional 3,4-dihydroxy-2-butanone 4-p...    89   7e-17
UniRef50_Q59AD7 GTP cyclohydrolase-2 (Fragment) n=2 Tax=Buchnera...    89   1e-16
UniRef50_UPI0001C31D71 34-dihydroxy-2-butanone 4-phosphate synth...    83   5e-15
UniRef50_O68249 3,4-dihydroxy-2-butanone 4-phosphate synthase n=...    77   4e-13
UniRef50_Q9ZL40 3,4-dihydroxy-2-butanone 4-phosphate synthase n=...    74   3e-12
UniRef50_Q9PHU4 3,4-dihydroxy-2-butanone 4-phosphate synthase n=...    72   1e-11
UniRef50_A8HP30 Bifunctional GTP cyclohydrolase (Fragment) n=3 T...    72   1e-11
UniRef50_Q0E2P5 Os02g0223200 protein (Fragment) n=2 Tax=Oryza sa...    69   1e-10
UniRef50_Q9APK4 GTP cyclohydrolase-2 (Fragment) n=1 Tax=Hyphomic...    58   1e-07
UniRef50_Q2GW54 Putative uncharacterized protein n=1 Tax=Chaetom...    56   7e-07
UniRef50_UPI0001B53FE8 hypothetical protein StAA4_17215 n=1 Tax=...    55   1e-06
UniRef50_C7MUB0 3,4-dihydroxy-2-butanone 4-phosphate synthase n=...    54   3e-06
UniRef50_B7FLV1 Putative uncharacterized protein n=1 Tax=Medicag...    53   6e-06

Sequences not found previously or not previously below threshold:

UniRef50_D0NPB4 Riboflavin biosynthesis protein ribBA, putative ...    42   0.012
UniRef50_A6RFL8 GTP cyclohydrolase-2 n=1 Tax=Ajellomyces capsula...    41   0.027
UniRef50_UPI0001699144 3,4-dihydroxy-2-butanone 4-phosphate synt...    39   0.060


CONVERGED!
>UniRef50_C5D3N0 GTP cyclohydrolase-2 n=25 Tax=cellular organisms RepID=RIBBA_GEOSW
          Length = 397

 Score =  311 bits (798), Expect = 8e-84,   Method: Composition-based stats.
 Identities = 114/193 (59%), Positives = 139/193 (72%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           +KR  E  LPT +G F  +G+  +  G +HVALV G+I    P L RVHSECLTGD   S
Sbjct: 204 VKREVEVMLPTEFGKFKAIGYTNIVDGKEHVALVKGEIIPDEPTLVRVHSECLTGDVFGS 263

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
            RCDCG QL AAL QI EEGRG+LLY RQEGR IGL+NK+RAY LQ+QGYDTVEAN +LG
Sbjct: 264 CRCDCGPQLHAALRQIEEEGRGVLLYMRQEGRGIGLINKLRAYKLQEQGYDTVEANERLG 323

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHY 182
           F AD RD+ + A + K LGV ++RLLTNNP+K+  L   G+ +VERVPL +  N  NE Y
Sbjct: 324 FPADLRDYGIGAQILKDLGVTKMRLLTNNPRKITGLKGHGLEVVERVPLQMPANKENEKY 383

Query: 183 LDTKAEKMGHLLN 195
           L TK EK+GH+L+
Sbjct: 384 LRTKYEKLGHMLH 396


>UniRef50_C9M9Y1 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
           n=1 Tax=Jonquetella anthropi E3_33 E1 RepID=C9M9Y1_9BACT
          Length = 416

 Score =  297 bits (762), Expect = 1e-79,   Method: Composition-based stats.
 Identities = 97/196 (49%), Positives = 130/196 (66%), Gaps = 3/196 (1%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFE---ELATGHDHVALVYGDISGHTPVLARVHSECLTGDA 59
           ++RVA   LP+ WGDF  + +    E      H+ALV GD+S     L RVHSEC+TGD 
Sbjct: 211 IERVASVHLPSAWGDFSAIAYRSQLETDPDRVHIALVKGDLSKEDAPLVRVHSECMTGDV 270

Query: 60  LFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANH 119
             SLRCDCG QL AA++ +   G G++LY RQEGR IGL+ K+RAY LQ++G DTV+AN 
Sbjct: 271 FGSLRCDCGPQLHAAMSMVERAGCGVVLYMRQEGRGIGLVEKLRAYELQEKGLDTVDANL 330

Query: 120 QLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNN 179
            LG   D RD+ + A + K LG+ ++RLLTNNP K+  L   G+ +VERVPL +  N  N
Sbjct: 331 ALGHKPDLRDYGVGAQILKDLGITKLRLLTNNPAKIVGLQGHGLEVVERVPLEIEPNRYN 390

Query: 180 EHYLDTKAEKMGHLLN 195
           + Y+ TK ++MGHLL+
Sbjct: 391 KKYMTTKEDRMGHLLH 406


>UniRef50_P74104 GTP cyclohydrolase-2 n=580 Tax=cellular organisms RepID=RIBBA_SYNY3
          Length = 556

 Score =  296 bits (758), Expect = 3e-79,   Method: Composition-based stats.
 Identities = 103/194 (53%), Positives = 137/194 (70%), Gaps = 2/194 (1%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDIS--GHTPVLARVHSECLTGDAL 60
           ++R    + P+ +G+F +  +  L    +H+A+V GD S  G  PV+ R+HSECLTGDAL
Sbjct: 207 VQRETICEFPSQFGEFKLYAYRNLLDQTEHIAIVKGDPSEFGQQPVMVRMHSECLTGDAL 266

Query: 61  FSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQ 120
            SLRCDC  QL+AAL  +   G G+++Y RQEGR IGL+NK++AY+LQD GYDTVEAN +
Sbjct: 267 GSLRCDCRMQLQAALKMLENHGLGVVVYLRQEGRGIGLVNKLKAYSLQDLGYDTVEANER 326

Query: 121 LGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNE 180
           LGF AD RD+ + A M   LGV ++RL+TNNP+K+  L   G+ IVERVPL++  N  N 
Sbjct: 327 LGFPADLRDYGMGAQMLNDLGVKQIRLITNNPRKIAGLKGYGLEIVERVPLLIEANDYNS 386

Query: 181 HYLDTKAEKMGHLL 194
           HYL TKAEK+GH L
Sbjct: 387 HYLTTKAEKLGHWL 400


>UniRef50_D1IKX7 Whole genome shotgun sequence of line PN40024,
           scaffold_17.assembly12x (Fragment) n=19 Tax=cellular
           organisms RepID=D1IKX7_VITVI
          Length = 845

 Score =  295 bits (755), Expect = 8e-79,   Method: Composition-based stats.
 Identities = 90/192 (46%), Positives = 120/192 (62%), Gaps = 1/192 (0%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           + R A A++PT WG F    +  +  G +H+A+V G+I     +L RVHSECLTGD   S
Sbjct: 623 VDRSAGARIPTMWGPFTAYCYRSILDGIEHIAMVKGEIGDGQDILVRVHSECLTGDIFGS 682

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
            RCDCG QL  A+ QI + G+G+L+Y R  EGR IGL +K+ AY LQD G DTVEAN +L
Sbjct: 683 ARCDCGNQLALAMQQIEKAGKGVLVYLRGHEGRGIGLGHKLHAYNLQDDGRDTVEANEEL 742

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181
           G   D R++ + A M + LGV  ++L+TNNP K   L   G+ +  RVPL+      N  
Sbjct: 743 GLPVDSREYGIGAQMLRDLGVRTMKLMTNNPAKYIGLKGYGLAVSGRVPLLTPITKENGR 802

Query: 182 YLDTKAEKMGHL 193
           YL+TK  KMGH+
Sbjct: 803 YLETKRSKMGHV 814


>UniRef50_B9HF78 Predicted protein (Fragment) n=10 Tax=cellular organisms
           RepID=B9HF78_POPTR
          Length = 449

 Score =  292 bits (747), Expect = 5e-78,   Method: Composition-based stats.
 Identities = 92/192 (47%), Positives = 121/192 (63%), Gaps = 1/192 (0%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           ++  A A +PT WG F    +  L  G +H+A+V G+I     +L RVHSECLTGD   S
Sbjct: 248 VELAAAAPIPTMWGPFKAYCYRSLLDGIEHIAMVKGEIGDGKDILVRVHSECLTGDIFGS 307

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
            RCDCG QL  A+ QI   GRG+L+Y R  EGR IGL +K+RAY LQD G DTVEAN +L
Sbjct: 308 ARCDCGKQLALAMKQIEAAGRGVLVYLRGHEGRGIGLGHKLRAYNLQDDGRDTVEANEEL 367

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181
           G   D R++ + A + + LGV+ ++L+TNNP K   L   G+ +  RVPL+      N  
Sbjct: 368 GLPVDSREYGIGAQILRDLGVHTMKLMTNNPAKYVGLKGYGLAVAGRVPLLTPITMENRR 427

Query: 182 YLDTKAEKMGHL 193
           YL+TK EKMGH+
Sbjct: 428 YLETKREKMGHV 439


>UniRef50_Q11WK6 GTP cyclohydrolase-2 n=44 Tax=Bacteria RepID=RIBBA_CYTH3
          Length = 405

 Score =  290 bits (744), Expect = 1e-77,   Method: Composition-based stats.
 Identities = 93/192 (48%), Positives = 128/192 (66%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           +KR     +PT  GDF ++ F +++TG  H+AL+ G      PV+ RVHS C+TGD   S
Sbjct: 210 VKREIGVDMPTNLGDFDLIAFRQISTGEVHLALIKGTWEKDEPVMVRVHSSCVTGDIFGS 269

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
            RCDCG QL  A+  I +EG+G++LY  QEGR IGLLNK++AY LQ+QG DTVEAN +LG
Sbjct: 270 CRCDCGPQLHKAMEMIQQEGKGVILYMNQEGRGIGLLNKLKAYKLQEQGRDTVEANLELG 329

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHY 182
           F  D+RD+   A + + L ++++RL+TNNP K   L   G+ I E VP+ +  NP+N  Y
Sbjct: 330 FKMDQRDYGTGAQILRDLNISKLRLITNNPVKRAALAGYGLEITEAVPIEIPSNPHNLEY 389

Query: 183 LDTKAEKMGHLL 194
           L TK +KMGH +
Sbjct: 390 LKTKRDKMGHTI 401


>UniRef50_A6T7Y5 GTP cyclohydrolase-2 n=139 Tax=cellular organisms RepID=RIBA_KLEP7
          Length = 200

 Score =  289 bits (741), Expect = 3e-77,   Method: Composition-based stats.
 Identities = 184/196 (93%), Positives = 187/196 (95%)

Query: 1   MQLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDAL 60
           MQLKRVAEAKLPTPWGDFLMVGFEELATG DHVALVYGDISG +PVLARVHSECLTGDAL
Sbjct: 1   MQLKRVAEAKLPTPWGDFLMVGFEELATGQDHVALVYGDISGQSPVLARVHSECLTGDAL 60

Query: 61  FSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQ 120
           FSLRCDCGFQLEAAL+ IAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQ
Sbjct: 61  FSLRCDCGFQLEAALSHIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQ 120

Query: 121 LGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNE 180
           LGFAADERDFTLCADMFKLL V +VRLLTNNPKKVEILTEAGINIVERVPLIVGRNP N 
Sbjct: 121 LGFAADERDFTLCADMFKLLNVEQVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPKNA 180

Query: 181 HYLDTKAEKMGHLLNK 196
           HYLDTKA KMGHLLN 
Sbjct: 181 HYLDTKAAKMGHLLNS 196


>UniRef50_C4Z7I1 GTP cyclohydrolase II / 3,4-dihydroxy 2-butanone 4-phosphate
           synthase n=19 Tax=Bacteria RepID=C4Z7I1_EUBE2
          Length = 400

 Score =  289 bits (740), Expect = 4e-77,   Method: Composition-based stats.
 Identities = 103/193 (53%), Positives = 131/193 (67%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           ++ VA  ++PT +G+F    +     G  HVALV GDI   + +L RVHSECLTGDA  S
Sbjct: 206 VECVAVTRMPTKYGEFTAHCYVNKLNGEHHVALVKGDIGDGSNLLCRVHSECLTGDAFGS 265

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
           ++CDCG QL +A+TQI  EGRG+LLY RQEGR IGL+NK++AYALQDQG DT+EAN  LG
Sbjct: 266 MKCDCGQQLASAMTQINNEGRGVLLYMRQEGRGIGLVNKLKAYALQDQGMDTLEANLALG 325

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHY 182
              D R++ + A + K LG   +RLLTNNP KV  L + GI I ERVP+ +     +  Y
Sbjct: 326 LPGDAREYYIGAQILKDLGAKSLRLLTNNPDKVYQLADFGIEISERVPIEIDATSFDRFY 385

Query: 183 LDTKAEKMGHLLN 195
           L TK  KMGH+LN
Sbjct: 386 LKTKQTKMGHILN 398


>UniRef50_A4VHT9 GTP cyclohydrolase-2 n=5 Tax=Proteobacteria RepID=A4VHT9_PSEU5
          Length = 242

 Score =  289 bits (740), Expect = 4e-77,   Method: Composition-based stats.
 Identities = 120/196 (61%), Positives = 148/196 (75%)

Query: 1   MQLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDAL 60
           + +  VA ++LPTP+G F M GF +  TG +HVAL  GD++   PVL R+HSECLTGDAL
Sbjct: 38  VSVVFVAASQLPTPFGVFTMHGFLDQDTGKEHVALTLGDVADGKPVLGRLHSECLTGDAL 97

Query: 61  FSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQ 120
           FSLRCDCGFQLEAAL  IA+EGRG+LLY RQEGR IGLLNKIRAY LQD G DTVEAN +
Sbjct: 98  FSLRCDCGFQLEAALRAIADEGRGVLLYLRQEGRGIGLLNKIRAYELQDAGADTVEANER 157

Query: 121 LGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNE 180
           LGFA D RD+ +C  M + LG+ E++L+TNNP+KV+ L   GI + ER PL +  NP+N 
Sbjct: 158 LGFAPDMRDYGICLPMLEHLGIGEIKLMTNNPRKVKALQGFGIRVAERKPLQIAHNPHNR 217

Query: 181 HYLDTKAEKMGHLLNK 196
            YL TKA K+GH+L +
Sbjct: 218 KYLATKAGKLGHMLGE 233


>UniRef50_P47924 GTP cyclohydrolase-2 n=36 Tax=cellular organisms RepID=RIBBA_ARATH
          Length = 543

 Score =  288 bits (737), Expect = 9e-77,   Method: Composition-based stats.
 Identities = 91/192 (47%), Positives = 123/192 (64%), Gaps = 1/192 (0%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           ++R + A++PT WG F    +  +  G +H+A+V G+I     +L RVHSECLTGD   S
Sbjct: 333 VERASAARIPTMWGPFTAYCYRSILDGIEHIAMVKGEIGDGQDILVRVHSECLTGDIFGS 392

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
            RCDCG QL  ++ QI   GRG+L+Y R  EGR IGL +K+RAY LQD G DTVEAN +L
Sbjct: 393 ARCDCGNQLALSMQQIEATGRGVLVYLRGHEGRGIGLGHKLRAYNLQDAGRDTVEANEEL 452

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181
           G   D R++ + A + + LGV  ++L+TNNP K   L   G+ IV RVPL+      N+ 
Sbjct: 453 GLPVDSREYGIGAQIIRDLGVRTMKLMTNNPAKYVGLKGYGLAIVGRVPLLSLITKENKR 512

Query: 182 YLDTKAEKMGHL 193
           YL+TK  KMGH+
Sbjct: 513 YLETKRTKMGHM 524


>UniRef50_Q2SA07 GTP cyclohydrolase-2 n=16 Tax=Bacteria RepID=RIBA_HAHCH
          Length = 207

 Score =  285 bits (730), Expect = 5e-76,   Method: Composition-based stats.
 Identities = 129/195 (66%), Positives = 152/195 (77%)

Query: 1   MQLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDAL 60
           M +  VA  KLPTP+G F M GF+E+ T  +H+AL  GDI     VLAR HSECLTGDAL
Sbjct: 1   MSVTYVASCKLPTPFGVFDMHGFQEVGTQKEHIALTLGDIGDGASVLARTHSECLTGDAL 60

Query: 61  FSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQ 120
           FS+RCDCG+QL+ AL  IA EGRGILLY RQEGR IGLLNKIRAY LQDQG DTVEAN Q
Sbjct: 61  FSMRCDCGYQLDEALRSIAAEGRGILLYLRQEGRGIGLLNKIRAYNLQDQGADTVEANEQ 120

Query: 121 LGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNE 180
           LGFAAD RD+++C  M   LG++ +RL+TNNP+KV+ LT+ GI +VERVPL VGRNP+N 
Sbjct: 121 LGFAADMRDYSMCKPMLYHLGISRIRLMTNNPRKVDSLTKLGIEVVERVPLEVGRNPHNR 180

Query: 181 HYLDTKAEKMGHLLN 195
           +YL TKA K+GHLL 
Sbjct: 181 NYLATKAGKLGHLLT 195


>UniRef50_A0PPL6 GTP cyclohydrolase-2 n=82 Tax=Bacteria RepID=RIBBA_MYCUA
          Length = 425

 Score =  285 bits (730), Expect = 6e-76,   Method: Composition-based stats.
 Identities = 103/199 (51%), Positives = 133/199 (66%), Gaps = 5/199 (2%)

Query: 2   QLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISG----HTPVLARVHSECLTG 57
            ++RVAEA++PT  G+F  +G+  +    +HVALV G+I+G       VL RVHSECLTG
Sbjct: 208 HIERVAEARIPTRRGEFRAIGYTSIYENVEHVALVRGEIAGPNSDGDDVLVRVHSECLTG 267

Query: 58  DALFSLRCDCGFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVE 116
           D   S RCDCG QL+AA+  +A EGRG++LY R  EGR IGLL+K++ Y LQD G DTV+
Sbjct: 268 DVFGSRRCDCGSQLDAAMAMVAREGRGVVLYMRGHEGRGIGLLHKLQTYQLQDAGDDTVD 327

Query: 117 ANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRN 176
           AN +LG  AD RD+ + A +   LGV  +RLLTNNP K   L   G++I+ERVPL V  N
Sbjct: 328 ANLKLGLPADARDYGIGAQILVDLGVRSMRLLTNNPAKRVGLDGYGLHIIERVPLPVRAN 387

Query: 177 PNNEHYLDTKAEKMGHLLN 195
             N  YL TK ++MGH L 
Sbjct: 388 AENIRYLMTKRDRMGHDLT 406


>UniRef50_A1T8K1 GTP cyclohydrolase-2 n=43 Tax=cellular organisms RepID=RIBBA_MYCVP
          Length = 423

 Score =  285 bits (729), Expect = 7e-76,   Method: Composition-based stats.
 Identities = 106/198 (53%), Positives = 132/198 (66%), Gaps = 5/198 (2%)

Query: 2   QLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISG----HTPVLARVHSECLTG 57
            + RVAEA++PT  G+F  VG+  +    +HVALV G+ISG       VL RVHSECLTG
Sbjct: 208 HIARVAEARIPTRHGEFRAVGYTSIYEDVEHVALVKGEISGPHSDGHDVLVRVHSECLTG 267

Query: 58  DALFSLRCDCGFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVE 116
           D   S RCDCG QL+AAL  +A EGRG++LY R  EGR IGL++K++AY LQD G DTV+
Sbjct: 268 DVFGSRRCDCGPQLDAALAMVAREGRGVVLYMRGHEGRGIGLMHKLQAYQLQDAGDDTVD 327

Query: 117 ANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRN 176
           AN +LG  AD RD+   A +   LGV  +RLLTNNP K   L   G++I+ERVPL V  N
Sbjct: 328 ANLKLGLPADARDYGTGAQILVDLGVRSMRLLTNNPAKRVGLDGYGLHIIERVPLPVRAN 387

Query: 177 PNNEHYLDTKAEKMGHLL 194
             N  YL TK ++MGH L
Sbjct: 388 AENIRYLMTKRDRMGHDL 405


>UniRef50_O84736 GTP cyclohydrolase-2 n=38 Tax=Bacteria RepID=RIBBA_CHLTR
          Length = 424

 Score =  285 bits (729), Expect = 8e-76,   Method: Composition-based stats.
 Identities = 100/194 (51%), Positives = 132/194 (68%), Gaps = 1/194 (0%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           + +++ A+LPT +GDF +  +E +  G  H ALV GDI     V  RVHSECLTGD L S
Sbjct: 211 VTKISSARLPTKYGDFSIHVYESIIDGTQHFALVKGDIHEQEAVPVRVHSECLTGDILGS 270

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
            RCDCG QL+ A+  IAEEG G+++Y R QEGR IG  +KIRAYALQD GYDTV+AN QL
Sbjct: 271 CRCDCGAQLDMAMRYIAEEGLGVIVYLRGQEGRGIGFGHKIRAYALQDLGYDTVDANLQL 330

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181
           GF  D R++ + A + K L +  VRL+T+NP+K   L   GI++++R+ L V  +  NE 
Sbjct: 331 GFPIDAREYGMAAQVLKDLQLTSVRLITHNPRKFFELQRLGIHVLDRIILPVSISTENEG 390

Query: 182 YLDTKAEKMGHLLN 195
           YL TK E+MGH L+
Sbjct: 391 YLRTKKERMGHWLD 404


>UniRef50_Q65SC0 GTP cyclohydrolase-2 n=55 Tax=Bacteria RepID=RIBA_MANSM
          Length = 219

 Score =  281 bits (719), Expect = 1e-74,   Method: Composition-based stats.
 Identities = 129/195 (66%), Positives = 158/195 (81%), Gaps = 2/195 (1%)

Query: 2   QLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHT--PVLARVHSECLTGDA 59
           +++RVAEA LPT +G F +VGFE   T  +HVALV GDIS     PVLAR+HSECLTGDA
Sbjct: 3   KIQRVAEANLPTEFGLFRIVGFEFPDTKKEHVALVMGDISNSEENPVLARIHSECLTGDA 62

Query: 60  LFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANH 119
           L SL+CDCGFQL  AL QI+E GRG+L+YHR+EGR IGL+NKIRAY+LQD G DT+EAN 
Sbjct: 63  LHSLKCDCGFQLSTALRQISEAGRGVLIYHREEGRGIGLINKIRAYSLQDNGMDTIEANL 122

Query: 120 QLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNN 179
            LGFAADER+F +CAD+F+LLG+ +VRLLTNNP K++ + +AGIN+VER+PL VG N  N
Sbjct: 123 ALGFAADERNFKVCADIFELLGICKVRLLTNNPAKIDTMKKAGINVVERIPLNVGENRYN 182

Query: 180 EHYLDTKAEKMGHLL 194
             YLDTKA+KMGH +
Sbjct: 183 TGYLDTKAKKMGHYI 197


>UniRef50_C9KJZ5 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
           n=1 Tax=Mitsuokella multacida DSM 20544
           RepID=C9KJZ5_9FIRM
          Length = 403

 Score =  279 bits (715), Expect = 3e-74,   Method: Composition-based stats.
 Identities = 99/192 (51%), Positives = 124/192 (64%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           +  VA+   P+ +G F +  +E        +A+V GD+ G   VL RVHSECLTGDAL S
Sbjct: 206 VHEVADVDFPSKYGHFRIHAYENELNNKCDIAIVKGDVRGKKDVLVRVHSECLTGDALGS 265

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
           +RCDCG QL  AL +I  EG G++LY RQEGR IGL NK+RAYALQD+G DTVEAN +LG
Sbjct: 266 MRCDCGDQLALALKKIEAEGEGVVLYMRQEGRGIGLANKMRAYALQDKGRDTVEANVELG 325

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHY 182
           FA D RD+ + A +   LG+  +RL+TNNP K   L   G+ I  RVPL V  N  ++ Y
Sbjct: 326 FAPDLRDYGIGAQILADLGLTSIRLMTNNPAKRAGLEGYGLEITGRVPLQVHANKFDKRY 385

Query: 183 LDTKAEKMGHLL 194
           L  K  KMGHL 
Sbjct: 386 LTVKKVKMGHLF 397


>UniRef50_Q4QNX8 GTP cyclohydrolase-2 n=78 Tax=cellular organisms RepID=RIBA_HAEI8
          Length = 216

 Score =  279 bits (714), Expect = 4e-74,   Method: Composition-based stats.
 Identities = 132/194 (68%), Positives = 158/194 (81%), Gaps = 1/194 (0%)

Query: 2   QLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISG-HTPVLARVHSECLTGDAL 60
           +++ VA+A LPT +G F MVGFE   T  +HVALV GDIS    PVLAR+HSECLTGDAL
Sbjct: 3   KIQLVAQANLPTEYGIFKMVGFEFPDTKKEHVALVMGDISNADEPVLARIHSECLTGDAL 62

Query: 61  FSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQ 120
            SL+CDCGFQL  AL QI EEGRG+L+YHR+EGR IGL+NKIRAY+LQD+G DT+EAN  
Sbjct: 63  HSLKCDCGFQLATALKQIQEEGRGVLIYHREEGRGIGLINKIRAYSLQDKGMDTIEANLA 122

Query: 121 LGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNE 180
           LGF ADER+F +CADMF+LLGV +VRL+TNNP+KVE + +AGIN+VERVPL VG N  N 
Sbjct: 123 LGFKADERNFEVCADMFELLGVKKVRLMTNNPEKVETMKKAGINVVERVPLNVGENRYNT 182

Query: 181 HYLDTKAEKMGHLL 194
            YLDTKA+KMGH +
Sbjct: 183 KYLDTKAKKMGHYI 196


>UniRef50_Q5F7N6 GTP cyclohydrolase-2 n=33 Tax=Bacteria RepID=RIBA_NEIG1
          Length = 197

 Score =  277 bits (709), Expect = 2e-73,   Method: Composition-based stats.
 Identities = 118/194 (60%), Positives = 145/194 (74%), Gaps = 1/194 (0%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           L  VA  +LPT WG F M GFEE A G +HVAL  G+ S   PVL R+HSECLTGDALFS
Sbjct: 5   LDHVASCRLPTEWGVFTMHGFEE-ANGQEHVALTVGNCSDGNPVLTRIHSECLTGDALFS 63

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
            +CDCG QLEAA+  +  EGRGI++Y RQEGR IGL+NKIRAY LQ+QG DTVEAN  LG
Sbjct: 64  RKCDCGPQLEAAMRAVQAEGRGIIVYLRQEGRGIGLINKIRAYHLQEQGMDTVEANLALG 123

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHY 182
              D RDF L   +++ LG+  V+LLTNNP+K++ L +AGIN+VER+PL VG N  NE Y
Sbjct: 124 LPVDARDFRLAQSIYEYLGIRSVKLLTNNPEKIQTLKDAGINVVERIPLHVGENLENERY 183

Query: 183 LDTKAEKMGHLLNK 196
           L TKA+K+GHL+++
Sbjct: 184 LQTKADKLGHLMSE 197


>UniRef50_C4GH90 GTP cyclohydrolase-2 n=1 Tax=Kingella oralis ATCC 51147
           RepID=C4GH90_9NEIS
          Length = 235

 Score =  277 bits (708), Expect = 2e-73,   Method: Composition-based stats.
 Identities = 111/192 (57%), Positives = 148/192 (77%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           L+ +   +LPT  G + M G+++  TG +H+ALV GDI+   PVL+RVHSECLTGDALFS
Sbjct: 42  LQHITSCRLPTEHGIYQMHGYQDSQTGQEHIALVMGDITTPEPVLSRVHSECLTGDALFS 101

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
            +CDCG QL+AA+  +A EGRG+++Y RQEGR IGL+NKIRAYALQD+G DTVEAN  LG
Sbjct: 102 QKCDCGPQLKAAMQAVAAEGRGVIVYLRQEGRGIGLINKIRAYALQDKGMDTVEANLALG 161

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHY 182
              D RDFTL  +++  LG+  +RLLTNNP+KV  L +AGI+I ER+PL VG +P N++Y
Sbjct: 162 LPVDARDFTLAKEIYDHLGIRSIRLLTNNPEKVHTLQQAGIHITERLPLHVGIHPENQNY 221

Query: 183 LDTKAEKMGHLL 194
           L+TKA+K+ H++
Sbjct: 222 LNTKAQKLNHMM 233


>UniRef50_C0VNE9 GTP cyclohydrolase-2 n=2 Tax=Moraxellaceae RepID=C0VNE9_9GAMM
          Length = 252

 Score =  276 bits (707), Expect = 3e-73,   Method: Composition-based stats.
 Identities = 113/194 (58%), Positives = 143/194 (73%), Gaps = 1/194 (0%)

Query: 1   MQLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYG-DISGHTPVLARVHSECLTGDA 59
           + ++ +A +KLPT +GDF +  F++  TG +HVAL  G + + + PVL R+HSECLTGDA
Sbjct: 53  VPIEFIATSKLPTAFGDFNISVFQDPETGEEHVALSKGLETAPNQPVLVRIHSECLTGDA 112

Query: 60  LFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANH 119
             SL+CDCG QL+A    I E G+G++LY RQEGR IGL NKIRAYALQDQG+DTV+AN 
Sbjct: 113 FASLKCDCGPQLQATQRLINEAGQGVILYLRQEGRGIGLTNKIRAYALQDQGHDTVDANL 172

Query: 120 QLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNN 179
            L   AD R + +C+ M   L V EV+LLTNNP K++ LT+ GIN+VERVPL VGRNP N
Sbjct: 173 LLNLPADARRYDMCSIMLDHLQVKEVKLLTNNPLKLKALTDLGINVVERVPLTVGRNPFN 232

Query: 180 EHYLDTKAEKMGHL 193
           EHYL TK E+M HL
Sbjct: 233 EHYLKTKRERMDHL 246


>UniRef50_Q13NP8 GTP cyclohydrolase-2 n=9 Tax=cellular organisms RepID=Q13NP8_BURXL
          Length = 224

 Score =  275 bits (705), Expect = 5e-73,   Method: Composition-based stats.
 Identities = 98/191 (51%), Positives = 124/191 (64%), Gaps = 1/191 (0%)

Query: 7   AEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCD 66
           A A LPT +G F    F    +G +H+ALV GD++  + VL R+HSECLTGD L S RCD
Sbjct: 32  ATATLPTRYGTFTSYVFRVCESGAEHLALVMGDVANKSSVLTRLHSECLTGDVLGSYRCD 91

Query: 67  CGFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAA 125
           CG QL+ AL  IA EG G+LLY R  EGR IGL NKIRAYALQ+QG DTVEAN  LG   
Sbjct: 92  CGEQLDLALRYIAAEGCGVLLYLRGHEGRGIGLSNKIRAYALQEQGRDTVEANLDLGLPD 151

Query: 126 DERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDT 185
           D R++   A + + L V  VRL++NNP+K + L++ GI + ERV L +     NE Y+ T
Sbjct: 152 DSREYDSAAGILRTLKVTSVRLMSNNPEKFDTLSKHGIPVCERVALAIPMREENERYIRT 211

Query: 186 KAEKMGHLLNK 196
           K  K GH  ++
Sbjct: 212 KQVKFGHYFDE 222


>UniRef50_P57863 GTP cyclohydrolase-2 n=17 Tax=Proteobacteria RepID=RIBA_PASMU
          Length = 219

 Score =  275 bits (703), Expect = 7e-73,   Method: Composition-based stats.
 Identities = 127/194 (65%), Positives = 159/194 (81%), Gaps = 1/194 (0%)

Query: 2   QLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISG-HTPVLARVHSECLTGDAL 60
           +++RV EA LPT +G F +VGFE   T  +HVALV G++     P+LAR+HSECLTGDAL
Sbjct: 3   KIQRVTEANLPTEFGMFRIVGFEFPDTKKEHVALVLGEVENTDEPILARIHSECLTGDAL 62

Query: 61  FSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQ 120
           +SL+CDCGFQL AAL QI++EGRG+L+YHR+EGR IGL+NKIRAY+LQD+G DT+EAN  
Sbjct: 63  YSLKCDCGFQLAAALRQISQEGRGVLIYHREEGRGIGLINKIRAYSLQDKGMDTIEANLA 122

Query: 121 LGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNE 180
           LGFAADER+F +CAD+F LLG+N+VRLLTNNP K++ + +AGINIVERV L VG N  N 
Sbjct: 123 LGFAADERNFEVCADIFALLGINKVRLLTNNPNKIDTMKKAGINIVERVALNVGENRYNT 182

Query: 181 HYLDTKAEKMGHLL 194
            YLDTKA+KMGH +
Sbjct: 183 EYLDTKAKKMGHFI 196


>UniRef50_C5CJ14 GTP cyclohydrolase II n=1 Tax=Kosmotoga olearia TBF 19.5.1
           RepID=C5CJ14_KOSOT
          Length = 390

 Score =  274 bits (701), Expect = 1e-72,   Method: Composition-based stats.
 Identities = 100/194 (51%), Positives = 125/194 (64%), Gaps = 1/194 (0%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           +K V+ A LPT +G F +V FE      +H A++YGDIS   PV  R+HSECLTGDAL S
Sbjct: 194 VKVVSIASLPTKFGTFQIVSFENNYDFLEHTAIIYGDISK-EPVPVRIHSECLTGDALGS 252

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
           LRCDCG QL+ A+  I  +GRGI+LY RQEGR IGL NKI+AY LQD G DTV+AN  LG
Sbjct: 253 LRCDCGSQLQNAMRYIKSQGRGIVLYLRQEGRGIGLHNKIKAYHLQDNGMDTVDANIALG 312

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHY 182
           F  D RD+ + A M + LGV ++ LL+NNP K+  L    I + E   +     P N  Y
Sbjct: 313 FPEDMRDYGVAAQMLRALGVKKIILLSNNPDKLRQLKHYQIIVDETRNIFGEITPYNHFY 372

Query: 183 LDTKAEKMGHLLNK 196
           L TK E+MGH   +
Sbjct: 373 LKTKMERMGHTFEE 386


>UniRef50_C8WEC3 GTP cyclohydrolase-2 n=10 Tax=Sphingomonadales RepID=C8WEC3_ZYMMN
          Length = 364

 Score =  269 bits (688), Expect = 4e-71,   Method: Composition-based stats.
 Identities = 103/199 (51%), Positives = 132/199 (66%), Gaps = 8/199 (4%)

Query: 3   LKRVAEAKLPTPWGDF-------LMVGFEELATGHDHVALVYGDISGHTPVLARVHSECL 55
           +   A A+LP   GD         +V F   A   +HVA++ G      P + R+HSECL
Sbjct: 167 VYIAARARLPIALGDHGKAIENSQIVAFRNDADAVEHVAVIIGHPD-GQPPVVRLHSECL 225

Query: 56  TGDALFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTV 115
           TGD   SL+CDCG QL  AL  + E G GILLY RQEGR IGL+NK+RAY+LQDQG+DTV
Sbjct: 226 TGDVFGSLKCDCGPQLHQALRIMDESGYGILLYLRQEGRGIGLINKLRAYSLQDQGFDTV 285

Query: 116 EANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGR 175
           +AN +LGF  D RDF L A M   L + ++RLLTNNP KVE L +AGI++VER+PL +  
Sbjct: 286 DANVRLGFVNDARDFRLAAQMLGELEIKQIRLLTNNPDKVEGLKKAGIDVVERLPLKIKP 345

Query: 176 NPNNEHYLDTKAEKMGHLL 194
           NP+N+ YL+TK ++ GH L
Sbjct: 346 NPHNQAYLETKRDRSGHQL 364


>UniRef50_D2RDK3 GTP cyclohydrolase II n=2 Tax=Archaeoglobaceae RepID=D2RDK3_ARCPR
          Length = 376

 Score =  268 bits (685), Expect = 9e-71,   Method: Composition-based stats.
 Identities = 99/194 (51%), Positives = 130/194 (67%), Gaps = 6/194 (3%)

Query: 3   LKRVAEAKLPTPW-GDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALF 61
           ++RV  A LPT + G F  VG++      + VALV G++S    VL R+HSECLTGD   
Sbjct: 183 VERVVSATLPTKFYGTFKAVGYKTPLG--EIVALVKGNVSEG-DVLVRIHSECLTGDVFH 239

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVEANHQ 120
           SLRCDCG QLE AL +I EEG+G+L+Y R  EGR IGL+NK+ AY LQ++G DTVEAN +
Sbjct: 240 SLRCDCGEQLERALKKIDEEGKGVLIYMRGHEGRGIGLINKLMAYKLQEEGKDTVEANVE 299

Query: 121 LGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNE 180
           LGF  D R + + A +   LGV  VRL+TNNP K+E L + G  +V R P+++     N+
Sbjct: 300 LGFPPDLRSYGIAAQILMDLGVKSVRLMTNNPNKIEELKKYGFKVV-REPIVIEPVEENK 358

Query: 181 HYLDTKAEKMGHLL 194
            YL TK EKMGH++
Sbjct: 359 KYLKTKMEKMGHMI 372


>UniRef50_D2R1R5 GTP cyclohydrolase II n=3 Tax=Planctomycetaceae RepID=D2R1R5_9PLAN
          Length = 403

 Score =  267 bits (683), Expect = 2e-70,   Method: Composition-based stats.
 Identities = 93/195 (47%), Positives = 129/195 (66%), Gaps = 3/195 (1%)

Query: 3   LKRVAEAKLPT-PWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALF 61
           + R+A+A++PT  +GDF ++ +E        V LV GD++     L R+HS C TGD L 
Sbjct: 206 VTRIAQAQIPTGQFGDFTIIAYEVKFETQTPVVLVKGDLTSVEAPLVRLHSSCFTGDLLD 265

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
           SLRCDCG QL+ AL  I +E  G+L+Y  QEGR IGL+ KI+AY LQ++G DTVEAN  L
Sbjct: 266 SLRCDCGDQLKKALEMIRDEKVGVLVYLPQEGRGIGLVEKIKAYDLQERGLDTVEANTAL 325

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILT--EAGINIVERVPLIVGRNPNN 179
           G+ AD RD+ +   + K LG+++VRL+TNNPKK +        + +V++VP+I   NP+N
Sbjct: 326 GYKADMRDYGVGIQILKDLGLSKVRLMTNNPKKTDAFIYGGFSLEVVDQVPIITESNPHN 385

Query: 180 EHYLDTKAEKMGHLL 194
             YL TK +KMGH L
Sbjct: 386 AKYLATKRDKMGHKL 400


>UniRef50_D1BH22 GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase
           n=4 Tax=Bacteria RepID=D1BH22_SANKS
          Length = 464

 Score =  265 bits (678), Expect = 6e-70,   Method: Composition-based stats.
 Identities = 99/196 (50%), Positives = 126/196 (64%), Gaps = 3/196 (1%)

Query: 2   QLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALV-YGDISGHTPVLARVHSECLTGDAL 60
           ++   + A+LPT  GDF + G+ +L TG +HVALV  G        + RVHSECLTGDA 
Sbjct: 223 RVHATSVAELPTAHGDFRVHGYRDLRTGAEHVALVPVGVEHPEEVPVVRVHSECLTGDAF 282

Query: 61  FSLRCDCGFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVEANH 119
            SLRCDCG QLEA++  +A EG G ++Y R  EGR IGLL KI AY LQD G DTV+AN 
Sbjct: 283 GSLRCDCGPQLEASMEIVAREG-GAVVYLRGHEGRGIGLLAKIAAYELQDAGRDTVQANL 341

Query: 120 QLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNN 179
            LG+ AD R++   A +   LG+  VRLLTNNP K   L   G+ + E V + VG + +N
Sbjct: 342 DLGWPADRREYGGAAAILVDLGLQRVRLLTNNPAKSTGLAAHGVEVTETVRIEVGHSQHN 401

Query: 180 EHYLDTKAEKMGHLLN 195
           E YL TK E MGH+L+
Sbjct: 402 ERYLRTKKELMGHVLD 417


>UniRef50_UPI0001905AE1 GTP cyclohydrolase II protein n=1 Tax=Rhizobium etli 8C-3
           RepID=UPI0001905AE1
          Length = 222

 Score =  264 bits (676), Expect = 9e-70,   Method: Composition-based stats.
 Identities = 96/196 (48%), Positives = 133/196 (67%), Gaps = 1/196 (0%)

Query: 2   QLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALF 61
           ++KR A++ +PT +GDF  + + +  TG +H+AL  G++     VL RVHSECLTG+A  
Sbjct: 1   RVKRYAQSFMPTRFGDFKAIAYRDSLTGTEHLALTLGELCEKEDVLVRVHSECLTGEAFR 60

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVEANHQ 120
           S+RCDCG QLE AL  +   G G ++Y R QEGR IGL NKI AY+LQD G DT+EAN +
Sbjct: 61  SMRCDCGQQLEMALRAVQLAGAGCVIYMRGQEGRGIGLGNKIAAYSLQDHGRDTLEANRE 120

Query: 121 LGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNE 180
           LGFA+D R++   AD+ + LG+  VRLLTNNP K+E L  +G+ +  R  LI   + +N 
Sbjct: 121 LGFASDSREYNAAADIIRDLGIGSVRLLTNNPTKIEALRTSGVIVSSRQSLIAASSASNI 180

Query: 181 HYLDTKAEKMGHLLNK 196
            YL TK ++ GHLL++
Sbjct: 181 TYLKTKRDRFGHLLDQ 196


>UniRef50_Q1D4N5 GTP cyclohydrolase-2 n=6 Tax=Cystobacterineae RepID=Q1D4N5_MYXXD
          Length = 224

 Score =  263 bits (673), Expect = 2e-69,   Method: Composition-based stats.
 Identities = 95/194 (48%), Positives = 125/194 (64%)

Query: 2   QLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALF 61
            L+R +EA +PT  G    + F +   G +HVALV G +SGH  V  R+HSECLT +   
Sbjct: 18  HLERFSEADIPTERGSLRTIVFRDKRNGREHVALVVGQVSGHEGVPVRIHSECLTSEVFG 77

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
           SL+CDC  QL+ +L  I + G+G++LY RQEGR IGL NKI+AYALQ +G DT EAN QL
Sbjct: 78  SLKCDCREQLDRSLDFITQAGQGVVLYLRQEGRGIGLGNKIKAYALQSKGLDTYEANRQL 137

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181
           GFA D R + + A+M + L V  V L+TNNP K+  + E GI +  R+P     NP+N  
Sbjct: 138 GFADDLRTYDIAAEMLRSLDVRSVDLMTNNPLKIAGMVEEGIPVRRRIPSRTEHNPHNVD 197

Query: 182 YLDTKAEKMGHLLN 195
           YL TK E+ GHL+ 
Sbjct: 198 YLRTKRERTGHLIE 211


>UniRef50_B8JBX2 GTP cyclohydrolase-2 n=5 Tax=Bacteria RepID=B8JBX2_ANAD2
          Length = 248

 Score =  262 bits (671), Expect = 4e-69,   Method: Composition-based stats.
 Identities = 97/185 (52%), Positives = 124/185 (67%)

Query: 11  LPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQ 70
           LPT  G F +V F       +HVALV+GD+ G   V  R+HSECLTGD + SLRCDC  Q
Sbjct: 38  LPTRAGPFRIVAFWNNRDAKEHVALVHGDVVGAADVPVRLHSECLTGDVMGSLRCDCRDQ 97

Query: 71  LEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDF 130
           L   L  I  EGRG+LLY RQEGR IGL+NKIRAYALQ+QG DTVEAN  LGF  DERD+
Sbjct: 98  LTEGLAAIQREGRGVLLYLRQEGRGIGLINKIRAYALQEQGLDTVEANLALGFRDDERDY 157

Query: 131 TLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAEKM 190
            + A M   L +  +RL+TNNP+K+  LT   +++  R+P ++    +N  YL+TKA + 
Sbjct: 158 AVAAHMIHGLELRSIRLITNNPEKIRQLTAYRVDVSGRIPHVIPPGEHNRFYLETKARRS 217

Query: 191 GHLLN 195
           GHL++
Sbjct: 218 GHLID 222


>UniRef50_Q9X2E6 GTP cyclohydrolase-2 n=13 Tax=cellular organisms RepID=RIBBA_THEMA
          Length = 388

 Score =  261 bits (668), Expect = 9e-69,   Method: Composition-based stats.
 Identities = 98/194 (50%), Positives = 123/194 (63%), Gaps = 3/194 (1%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           +K+ AEA LPT +G F +V FE    G +H A+V   +    PV  R+HSEC+TGD L S
Sbjct: 191 MKKKAEATLPTDFGVFKVVSFENHLDGKEHFAIVKEPLE--DPVAVRIHSECVTGDVLSS 248

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
           LRCDCG QL   L  ++  G GIL+Y RQEGR IGL NKI AY+LQD+G DTVEAN  LG
Sbjct: 249 LRCDCGSQLANFLRYMSAHG-GILIYLRQEGRGIGLSNKIAAYSLQDKGLDTVEANRVLG 307

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHY 182
           F+ DERD+   A + K LG+  V L TNN +K   L + GI +VE   L     P+N  Y
Sbjct: 308 FSEDERDYAPAAQILKALGIERVLLFTNNQRKTVGLEKYGIEVVETKRLYGRVTPHNRFY 367

Query: 183 LDTKAEKMGHLLNK 196
           L TK +K+GH L +
Sbjct: 368 LSTKMKKLGHELEE 381


>UniRef50_O29766 GTP cyclohydrolase-2 n=1 Tax=Archaeoglobus fulgidus
           RepID=RIBA_ARCFU
          Length = 378

 Score =  259 bits (663), Expect = 3e-68,   Method: Composition-based stats.
 Identities = 96/194 (49%), Positives = 122/194 (62%), Gaps = 6/194 (3%)

Query: 3   LKRVAEAKLPTPW-GDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALF 61
           ++RV EA LPT + G F  VG++      + VALV G +     VL R+HSECLTGD   
Sbjct: 185 VERVIEATLPTKFYGTFRAVGYKTPLG--EIVALVKGRVDEG-DVLVRIHSECLTGDVFH 241

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVEANHQ 120
           SLRCDCG QLE AL  I  EG+G+ +Y R  EGR IGL+NK+ AY LQ++G DTV+AN +
Sbjct: 242 SLRCDCGDQLENALKMIDREGKGVAIYMRGHEGRGIGLINKLMAYKLQEEGKDTVDANIE 301

Query: 121 LGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNE 180
           LGF  D R + + A +   L V  +RLLTNNP K+E L + G  IV R P+ V     N 
Sbjct: 302 LGFPPDMRSYGIAAQILMDLKVKSIRLLTNNPLKIEELKKYGFKIV-REPIEVEPCEVNL 360

Query: 181 HYLDTKAEKMGHLL 194
            YL  K +KMGHL+
Sbjct: 361 PYLKAKKDKMGHLI 374


>UniRef50_D0LLG6 GTP cyclohydrolase-2 n=1 Tax=Haliangium ochraceum DSM 14365
           RepID=D0LLG6_HALO1
          Length = 214

 Score =  259 bits (662), Expect = 5e-68,   Method: Composition-based stats.
 Identities = 97/194 (50%), Positives = 127/194 (65%)

Query: 1   MQLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDAL 60
           + L++ A +KLPT  G F +  +       + +A+  G  +   P   RVHSEC TG+ L
Sbjct: 12  VSLEKYATSKLPTIHGQFEVTVYRYGPDSEEALAVTLGSFAPDEPTFVRVHSECYTGEVL 71

Query: 61  FSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQ 120
            SL+CDC  QLE ALT+I E GRG+L+Y RQEGR IGL NKIRAYALQDQG DTV+ANHQ
Sbjct: 72  GSLKCDCREQLELALTRIQELGRGVLVYLRQEGRGIGLGNKIRAYALQDQGADTVQANHQ 131

Query: 121 LGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNE 180
           LGFA D R+F + A++ K LGV  + L TNNP+K++ + + GI +V R P     NP+N 
Sbjct: 132 LGFATDLREFDVAAEILKDLGVARIHLHTNNPEKIQAMEDHGIELVSREPAHGVINPHNR 191

Query: 181 HYLDTKAEKMGHLL 194
            YL+TK   +GH  
Sbjct: 192 RYLETKHHTLGHDF 205


>UniRef50_B0RC63 Riboflavin biosynthesis protein RibA n=7 Tax=Actinomycetales
           RepID=B0RC63_CLAMS
          Length = 453

 Score =  258 bits (660), Expect = 7e-68,   Method: Composition-based stats.
 Identities = 93/192 (48%), Positives = 130/192 (67%), Gaps = 3/192 (1%)

Query: 2   QLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALF 61
           ++    E  +PT  G   +  + +  TG DHVA+V G+   H   L RVHSECLTG+AL 
Sbjct: 219 RVIFEVETTVPTTHGSVKLRAYRDRTTGADHVAIVAGEPRAHG-TLVRVHSECLTGEALG 277

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVEANHQ 120
           SL+C+CG QL+AAL +I  +G G+++Y R  EGR IGL+NK+RAY LQ+ G+DT++AN  
Sbjct: 278 SLKCECGPQLDAALDEIQRDG-GVVVYLRGHEGRGIGLINKLRAYRLQEDGFDTLDANVA 336

Query: 121 LGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNE 180
           LG  AD RD+   + + + +G+ +VRLLTNNP+KV  L   G+ + ERVPL+VG N  N 
Sbjct: 337 LGLPADARDYGAASAILQEMGIEDVRLLTNNPEKVRQLEAHGVEVTERVPLVVGVNEVNA 396

Query: 181 HYLDTKAEKMGH 192
            YL+TK ++MGH
Sbjct: 397 GYLETKRDRMGH 408


>UniRef50_Q4L7B1 GTP cyclohydrolase-2 n=3 Tax=Staphylococcus RepID=RIBBA_STAHJ
          Length = 393

 Score =  257 bits (657), Expect = 2e-67,   Method: Composition-based stats.
 Identities = 91/193 (47%), Positives = 120/193 (62%), Gaps = 3/193 (1%)

Query: 2   QLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALF 61
            ++  A+  +PT  G F M GFE   T  + V L  G+         R+HS CLTGD   
Sbjct: 204 SVELKAKVNMPTDHGAFEMYGFESSLTKEEIVVLAKGEPRVTEN--VRIHSACLTGDIFH 261

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
           S RCDCG QLE+A+  I E G G+++Y  QEGR IGL+NK+RAY L +QG+DTV AN  L
Sbjct: 262 SQRCDCGAQLESAMKYINEHG-GMIIYLPQEGRGIGLINKLRAYELIEQGHDTVTANLAL 320

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181
           GF  D RD+ + A +     V +V LL+NNPKK E L+E GI + +R P+IV  N +N  
Sbjct: 321 GFDEDLRDYHIAAQILNYFNVQQVNLLSNNPKKFEGLSEYGIKVADRTPIIVAENEHNHD 380

Query: 182 YLDTKAEKMGHLL 194
           Y++TK  KMGHL+
Sbjct: 381 YMNTKKIKMGHLI 393


>UniRef50_Q6GFT5 GTP cyclohydrolase-2 n=76 Tax=Bacteria RepID=RIBBA_STAAR
          Length = 393

 Score =  257 bits (657), Expect = 2e-67,   Method: Composition-based stats.
 Identities = 91/193 (47%), Positives = 122/193 (63%), Gaps = 3/193 (1%)

Query: 2   QLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALF 61
           +++  A+ K+PT +G F M GF+   T  + V L  G I  H     R+HS CLTGD   
Sbjct: 204 EIEFKAKVKMPTDFGTFDMYGFKATYTDEEIVVLTKGAIRQHEN--VRLHSACLTGDIFH 261

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
           S RCDCG QLE+++  I E G G+++Y  QEGR IGLLNK+RAY L +QGYDTV AN  L
Sbjct: 262 SQRCDCGAQLESSMKYINEHG-GMIIYLPQEGRGIGLLNKLRAYELIEQGYDTVTANLAL 320

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181
           GF  D RD+ + A + K   +  + LL+NNP K E L + GI+I ER+ +IV    +N  
Sbjct: 321 GFDEDLRDYHIAAQILKYFNIEHINLLSNNPSKFEGLKQYGIDIAERIEVIVPETVHNHD 380

Query: 182 YLDTKAEKMGHLL 194
           Y++TK  KMGHL+
Sbjct: 381 YMETKKIKMGHLI 393


>UniRef50_P43525 GTP cyclohydrolase-2 n=6 Tax=Alphaproteobacteria RepID=RIBA_AZOBR
          Length = 385

 Score =  257 bits (656), Expect = 2e-67,   Method: Composition-based stats.
 Identities = 100/193 (51%), Positives = 131/193 (67%), Gaps = 1/193 (0%)

Query: 3   LKRVAEAKLPTPWGDFL-MVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALF 61
           L+RVAEA++P    +   +  F  +  G +H+A++ G+     PVLAR+HSEC TGD L 
Sbjct: 193 LRRVAEARVPLSGAENTSIAAFRPIDGGPEHLAIIVGNPVAGEPVLARLHSECFTGDLLA 252

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
            LRCDCG QL  A+ +IA  G G+LLY  QEGR IGL+NK+RAY +QD+G+DTV+AN  L
Sbjct: 253 GLRCDCGQQLRGAIAEIARHGSGVLLYLAQEGRGIGLVNKLRAYRIQDRGFDTVDANEIL 312

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181
           GF ADER +   A+M + LG   VRL+TNNP+K+  L   GI +VERVP I   N +NE 
Sbjct: 313 GFEADERVYLPAAEMLRQLGFTAVRLMTNNPEKLRQLARCGIEVVERVPHIFPANGHNEG 372

Query: 182 YLDTKAEKMGHLL 194
           YL TKAE+ GH+ 
Sbjct: 373 YLRTKAERSGHMF 385


>UniRef50_A6C5C2 Riboflavin biosynthesis protein RibA n=1 Tax=Planctomyces maris DSM
           8797 RepID=A6C5C2_9PLAN
          Length = 416

 Score =  255 bits (653), Expect = 5e-67,   Method: Composition-based stats.
 Identities = 94/195 (48%), Positives = 125/195 (64%), Gaps = 3/195 (1%)

Query: 3   LKRVAEAKLPTP-WGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALF 61
           + R  E  + T  +G   ++G+         VALV+GD+      L R+HS C TGD L 
Sbjct: 216 VHREVEVPINTKNYGTVQVIGYSVEHESQQPVALVWGDLHSVEAPLVRMHSSCFTGDLLD 275

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
           SLRCDCG QL  A++ I + G G ++Y  QEGR IGL+ K++AY LQDQGYDTVEAN QL
Sbjct: 276 SLRCDCGDQLHMAMSAINQAGAGAVVYLPQEGRGIGLIPKLKAYVLQDQGYDTVEANIQL 335

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEI--LTEAGINIVERVPLIVGRNPNN 179
           GF AD RDFT+   + K LG+ +VRLLTNNPKK +    T   + +VE+VP++   + + 
Sbjct: 336 GFKADSRDFTVGVQILKDLGLTKVRLLTNNPKKTDSDVYTGFNLEVVEQVPIVAPPHKDR 395

Query: 180 EHYLDTKAEKMGHLL 194
           E YL TK +KMGH+L
Sbjct: 396 EFYLQTKRDKMGHIL 410


>UniRef50_Q1GKN3 GTP cyclohydrolase-2 n=44 Tax=Rhodobacterales RepID=Q1GKN3_SILST
          Length = 362

 Score =  255 bits (653), Expect = 5e-67,   Method: Composition-based stats.
 Identities = 106/193 (54%), Positives = 131/193 (67%), Gaps = 1/193 (0%)

Query: 3   LKRVAEAKLPTPWGDF-LMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALF 61
           L  VA A+LP    +   +  F     G +H A+  G      PVLAR+HS C TGD L 
Sbjct: 170 LHPVAAARLPMEASEAGRLHIFRPEDGGEEHYAIEIGRPDRSQPVLARLHSACFTGDVLG 229

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
           SL+CDCG QL  AL+ + +EG GILLY  QEGR IGL NK+RAY+LQDQG+DTVEANH+L
Sbjct: 230 SLKCDCGPQLRGALSHMGQEGAGILLYLNQEGRGIGLANKMRAYSLQDQGFDTVEANHRL 289

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181
           GF  DERDF L A + + LG + VRL+TNNP K+ ++ + GI++VERVPL VG N  N H
Sbjct: 290 GFEDDERDFRLGASILRELGFSSVRLMTNNPGKIAMMEKTGISVVERVPLKVGENAFNRH 349

Query: 182 YLDTKAEKMGHLL 194
           YL TKA K GH+L
Sbjct: 350 YLATKAAKSGHML 362


>UniRef50_A8IZV5 Bifunctional GTP cyclohydrolase II n=1 Tax=Chlamydomonas
           reinhardtii RepID=A8IZV5_CHLRE
          Length = 370

 Score =  254 bits (650), Expect = 1e-66,   Method: Composition-based stats.
 Identities = 84/196 (42%), Positives = 118/196 (60%), Gaps = 4/196 (2%)

Query: 5   RVAEAKLPTPWGDFLMVGFEELATG----HDHVALVYGDISGHTPVLARVHSECLTGDAL 60
            +AE  LPT  G F + G++    G     +  A+V G + G   V  RVH  C T + L
Sbjct: 85  FIAETLLPTRHGKFRLRGYKHSTDGGATFTEPTAIVSGKVEGQEDVAVRVHDACFTSEVL 144

Query: 61  FSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQ 120
            SL+CDC  QLE AL  I     GI++Y +QEGR IGL NKI AY+LQ+QG DTV+AN  
Sbjct: 145 GSLKCDCAEQLELALRMIQGAPPGIVIYLQQEGRGIGLANKIAAYSLQEQGLDTVDANRA 204

Query: 121 LGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNE 180
           LG   D R++T   +M + +GV  +RL+TNNP+K+  LT+ GI +  R+P +V     N+
Sbjct: 205 LGLPDDCREYTSVRNMLQDMGVKSIRLITNNPRKINTLTKLGIQVNGRIPCLVAAGAYNQ 264

Query: 181 HYLDTKAEKMGHLLNK 196
            YL+ K ++M H+L +
Sbjct: 265 GYLEAKRDRMAHMLPE 280


>UniRef50_Q4FV65 GTP cyclohydrolase-2 n=3 Tax=Psychrobacter RepID=Q4FV65_PSYA2
          Length = 230

 Score =  254 bits (650), Expect = 1e-66,   Method: Composition-based stats.
 Identities = 106/220 (48%), Positives = 130/220 (59%), Gaps = 26/220 (11%)

Query: 1   MQLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHT---------------- 44
           M  + +  AKLPT  G+F +  FE    G +HV L  G                      
Sbjct: 1   MSYQFITSAKLPTRHGEFDIHIFEN-DEGQEHVMLTVGLPVVDQTDTTDSLPSPDTILNQ 59

Query: 45  ---------PVLARVHSECLTGDALFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRN 95
                      L R+HSECLTGDA  SL+CDCG QL  A+  I E G G +LY RQEGR 
Sbjct: 60  EDNALSERPIPLIRIHSECLTGDAFSSLKCDCGPQLNTAMHAIQETGCGAILYLRQEGRG 119

Query: 96  IGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKV 155
           IGL NKIRAYALQDQG+DT++AN  LG  AD R + +C  M   +GV+ VRL+TNNP KV
Sbjct: 120 IGLTNKIRAYALQDQGHDTLDANLMLGLPADARIYDMCGPMLAHIGVDAVRLITNNPSKV 179

Query: 156 EILTEAGINIVERVPLIVGRNPNNEHYLDTKAEKMGHLLN 195
             LTE GI+++ERVPL+VG N  N  YL TK ++MGHLL+
Sbjct: 180 AYLTEHGIDVIERVPLVVGVNDMNAEYLATKRDRMGHLLD 219


>UniRef50_C0YM11 GTP cyclohydrolase-2 n=2 Tax=Chryseobacterium gleum ATCC 35910
           RepID=C0YM11_9FLAO
          Length = 198

 Score =  252 bits (645), Expect = 4e-66,   Method: Composition-based stats.
 Identities = 88/194 (45%), Positives = 130/194 (67%), Gaps = 2/194 (1%)

Query: 3   LKRVAEAKLPTPWGDFLMVGF-EELATGHDHVALVYGDISGHTPVLARVHSECLTGDALF 61
           +K  AEA +PT  G F M+ F E       H+A++  +     PV  R HSEC+TG+   
Sbjct: 2   IKIQAEANVPTEHGTFRMIAFSENENDWMPHMAIIAENTDFSKPVNVRFHSECITGEVFH 61

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
           S +C+CG QL+AA+  I E G GI++Y RQEGRNIG++NK++AY+LQ++G DTV+AN QL
Sbjct: 62  SKKCECGQQLDAAMKYIHENG-GIIIYLRQEGRNIGIINKLKAYSLQEKGLDTVQANLQL 120

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181
           G  AD+R+F +  ++  LL V ++ LLTNNP+KV+ + ++ I++  RVPL +  N  ++ 
Sbjct: 121 GLPADDRNFGVAIEILNLLDVKDINLLTNNPEKVKYVVDSNIHLNSRVPLQIPANEISKG 180

Query: 182 YLDTKAEKMGHLLN 195
           YL TK +  GHLL+
Sbjct: 181 YLQTKKDFFGHLLD 194


>UniRef50_Q1IPQ1 GTP cyclohydrolase-2 n=4 Tax=Bacteria RepID=Q1IPQ1_ACIBL
          Length = 224

 Score =  252 bits (644), Expect = 6e-66,   Method: Composition-based stats.
 Identities = 99/213 (46%), Positives = 128/213 (60%), Gaps = 21/213 (9%)

Query: 2   QLKRVAEAKLPTPWGDFLMVGFEELATG--------------------HDHVALVYGDIS 41
            + ++AEA  PT WG F + GFE                            VALV GDI 
Sbjct: 12  HVIKMAEADFPTRWGRFRIYGFEGTFEEVPDSASANDLARDGVIERRKESAVALVMGDIH 71

Query: 42  GHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNK 101
              P L R+HS+CLTGD   S RCDC  QLE AL  I++ G G+L+Y  QEGR IGL+ K
Sbjct: 72  -SQPPLVRIHSQCLTGDVFGSQRCDCRQQLELALQMISDAGNGVLIYEEQEGRGIGLMAK 130

Query: 102 IRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEA 161
           ++AY LQD+G DTVEAN QLG  AD R +TL  ++ K LG+  +RLL+NNP+KV+ + +A
Sbjct: 131 LQAYELQDKGLDTVEANEQLGLKADYRQYTLPVEIMKALGITRLRLLSNNPEKVKAVEDA 190

Query: 162 GINIVERVPLIVGRNPNNEHYLDTKAEKMGHLL 194
           GI +VERV   V   P ++ YL TK +KMGH+ 
Sbjct: 191 GIEVVERVSAEVEAYPTSKAYLQTKKDKMGHIF 223


>UniRef50_C9MTM9 GTP cyclohydrolase-2 n=1 Tax=Prevotella veroralis F0319
           RepID=C9MTM9_9BACT
          Length = 205

 Score =  252 bits (644), Expect = 6e-66,   Method: Composition-based stats.
 Identities = 88/196 (44%), Positives = 128/196 (65%), Gaps = 1/196 (0%)

Query: 1   MQLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTP-VLARVHSECLTGDA 59
           +++ +  +  +PT WGDF M+ F     G D   +  G++       + R+HS C +GD 
Sbjct: 4   IKVVKGEKVHMPTIWGDFFMIPFHNEDDGKDCFVVGKGNVLNSVNIPIVRIHSSCSSGDI 63

Query: 60  LFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANH 119
           L SLRCDCG QL  AL  I ++G G+L+Y  QEGR IGL++K++AY LQ+QG DTV+AN 
Sbjct: 64  LGSLRCDCGEQLHKALKLIEQKGEGLLIYLNQEGRGIGLMDKMKAYKLQEQGVDTVDANL 123

Query: 120 QLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNN 179
           Q+G + DERD+ + A + KLLG++E+ LLTNN  K + L   GIN+ + +PL    N  N
Sbjct: 124 QIGHSVDERDYAIGAAILKLLGISEIDLLTNNLLKSQGLIRNGINVRKIIPLETSPNKYN 183

Query: 180 EHYLDTKAEKMGHLLN 195
           + YL+TK ++MGHLL+
Sbjct: 184 KFYLETKKKRMGHLLH 199


>UniRef50_UPI000050F87F bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP
           cyclohydrolase II protein n=1 Tax=Brevibacterium linens
           BL2 RepID=UPI000050F87F
          Length = 464

 Score =  250 bits (638), Expect = 2e-65,   Method: Composition-based stats.
 Identities = 96/208 (46%), Positives = 123/208 (59%), Gaps = 18/208 (8%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYG--------DISGHTP------VLA 48
           ++  AE  LPT  G F    F     GHDH+ +  G        + +G  P       L 
Sbjct: 240 IEASAEVPLPTKHGSFSARAF--TIDGHDHLGVFSGIDSAAVAHEPAGQEPSLHGPAPLV 297

Query: 49  RVHSECLTGDALFSLRCDCGFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYAL 107
           RVHSECLTGD   S RCDCG QL+ AL QI++EG G ++Y    EGR IGL NK+RAYAL
Sbjct: 298 RVHSECLTGDVFGSHRCDCGEQLDLALQQISDEG-GTVIYMTGHEGRGIGLSNKLRAYAL 356

Query: 108 QDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVE 167
           QD+G DTV+AN +LGF  D+RD+   A++ + +G+  +RLLTNNP K   L   GI I  
Sbjct: 357 QDRGLDTVDANRELGFHDDDRDYRAAAEILRSIGLTHIRLLTNNPDKTRALESLGITIEA 416

Query: 168 RVPLIVGRNPNNEHYLDTKAEKMGHLLN 195
            VPL +   P N +YL+TK E+M H L 
Sbjct: 417 VVPLEIPARPENSNYLNTKRERMHHTLT 444


>UniRef50_A0JVK1 GTP cyclohydrolase-2 n=2 Tax=Micrococcaceae RepID=A0JVK1_ARTS2
          Length = 237

 Score =  249 bits (637), Expect = 3e-65,   Method: Composition-based stats.
 Identities = 94/188 (50%), Positives = 118/188 (62%), Gaps = 3/188 (1%)

Query: 9   AKLPTPWGDFLMVGFEELATGHDHVALVYG-DISGHTPVLARVHSECLTGDALFSLRCDC 67
            +LP+ +GDF+   + +L TG +H+A+            L R+HSECLTGD   S RCDC
Sbjct: 25  VQLPSEFGDFVAQAWTDLVTGAEHLAVSSPIPPVDGKAPLVRLHSECLTGDVFGSYRCDC 84

Query: 68  GFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAAD 126
           G QL  AL +I EEG G LLY R QEGR IGL NKI+AYALQ+ G+DTVEAN QLG   D
Sbjct: 85  GEQLAYALEKINEEG-GTLLYLRGQEGRGIGLANKIKAYALQEAGFDTVEANEQLGLPVD 143

Query: 127 ERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTK 186
            R +   A +   LG++EVRLL+NNP K   L +AG+ +VE VP  V     N  YL TK
Sbjct: 144 ARCYNAAAQILAELGLHEVRLLSNNPDKQNRLADAGVTVVEMVPTEVPSREQNIRYLQTK 203

Query: 187 AEKMGHLL 194
            ++M H L
Sbjct: 204 KDRMDHRL 211


>UniRef50_A9FWS8 GTP cyclohydrolase-2 n=1 Tax=Sorangium cellulosum 'So ce 56'
           RepID=A9FWS8_SORC5
          Length = 225

 Score =  248 bits (634), Expect = 8e-65,   Method: Composition-based stats.
 Identities = 97/202 (48%), Positives = 120/202 (59%), Gaps = 7/202 (3%)

Query: 2   QLKRVAEAKLPTPWGDFLMVGFEELAT-------GHDHVALVYGDISGHTPVLARVHSEC 54
           QL   A+A +PT  G F M+ F    T         DHVALV GD+ G + V  RVHSEC
Sbjct: 11  QLDIRAQAPVPTKHGVFQMLVFHFGGTTSPDQGLSPDHVALVMGDVRGRSDVTLRVHSEC 70

Query: 55  LTGDALFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDT 114
           LT +   SL+CDC  QLEAA  +I   G G++LY RQEGR IGL NKIRAY LQ  G+DT
Sbjct: 71  LTSEVFGSLKCDCREQLEAAQAEIGRRGLGVVLYLRQEGRGIGLANKIRAYQLQAFGHDT 130

Query: 115 VEANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVG 174
           V+AN  LG   D R +   A M + LG+  +RLLTNNP KV+ L   G+ I  R   IV 
Sbjct: 131 VDANRILGLPDDARGYEPAAAMIEHLGIESIRLLTNNPDKVDALRALGVRIASRSAAIVP 190

Query: 175 RNPNNEHYLDTKAEKMGHLLNK 196
            NP +  YL+ K  +MGH++  
Sbjct: 191 ANPFSAPYLEAKRLRMGHVIPS 212


>UniRef50_C1E155 Predicted protein n=2 Tax=Micromonas RepID=C1E155_9CHLO
          Length = 357

 Score =  247 bits (630), Expect = 2e-64,   Method: Composition-based stats.
 Identities = 86/196 (43%), Positives = 119/196 (60%), Gaps = 5/196 (2%)

Query: 4   KRVAEAKLPTPWGDFLMVGFEELATG---HDHVALVYGDISGHTPVLARVHSECLTGDAL 60
           + +AE KLPT  G + + G+     G    + VA+ +GDI G   V  RVH  C T + L
Sbjct: 126 EFIAETKLPTGSGFYRLRGYRHSVDGGVPSEPVAICFGDIEGREKVPVRVHDACFTSEVL 185

Query: 61  FSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQD-QGYDTVEANH 119
            SL+CDC  QL+ A+  I E   G+++Y  QEGR IGL NKI AYALQD QG DTV+AN 
Sbjct: 186 GSLKCDCKQQLQLAMEYIQEN-DGMVIYLHQEGRGIGLANKIAAYALQDTQGLDTVDANR 244

Query: 120 QLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNN 179
            LG   D R++T  A++ + +G+  ++L+TNNP+KV  L   G+ I  R+P IV  N  N
Sbjct: 245 ALGLPDDVREYTAVANILEDMGIRSIQLMTNNPRKVATLERLGVKIEGRIPCIVKANLFN 304

Query: 180 EHYLDTKAEKMGHLLN 195
           + YL+ K  +M H L+
Sbjct: 305 QGYLEAKEGRMKHFLD 320


>UniRef50_C7JCF3 Bifunctional protein 3,4-dihydroxy-2-butanone 4-phosphate
           synthase/GTP cyclohydrolase II n=8 Tax=Acetobacter
           pasteurianus RepID=C7JCF3_ACEP3
          Length = 437

 Score =  246 bits (629), Expect = 2e-64,   Method: Composition-based stats.
 Identities = 96/198 (48%), Positives = 128/198 (64%), Gaps = 5/198 (2%)

Query: 3   LKRVAEAKLPTPWG--DFLMVGFEELATGHDHVALVYGDISGHTP-VLARVHSECLTGDA 59
           +  +A+A LP+ +G  D ++  +++   G +HVALV GD+       L R+HSEC+TGDA
Sbjct: 229 VPDLAQASLPSAYGGDDLVIHAYQDE-NGVEHVALVKGDVRRKGAVPLVRLHSECVTGDA 287

Query: 60  LFSLRCDCGFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVEAN 118
           L SLRCDCG QL AAL  I +   G+L+Y R  EGR IGL+NKIRAY LQD G DTV+AN
Sbjct: 288 LGSLRCDCGSQLHAALRAIGKAECGVLVYVRGHEGRGIGLVNKIRAYELQDAGLDTVDAN 347

Query: 119 HQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPN 178
           H+LGFA D RD+   + + + LGV E+ LLTNNP KV  L   G  +  R+ L +   P+
Sbjct: 348 HRLGFATDARDWRAASGILRSLGVGELDLLTNNPDKVRALEARGFMVRRRIGLEIPPTPH 407

Query: 179 NEHYLDTKAEKMGHLLNK 196
           N  YL+ K  +MGH L +
Sbjct: 408 NRAYLEAKRRRMGHHLGQ 425


>UniRef50_A4XHM6 GTP cyclohydrolase II n=2 Tax=Clostridia RepID=A4XHM6_CALS8
          Length = 402

 Score =  246 bits (629), Expect = 3e-64,   Method: Composition-based stats.
 Identities = 80/192 (41%), Positives = 115/192 (59%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           +++ AEA LPT +G F +  F+   +  +H  L+    +   PV  R+HS C TGD   S
Sbjct: 200 VQKEAEANLPTQYGKFKIFVFKNYFSQKEHAVLINQTFNPSQPVNVRIHSSCKTGDVFHS 259

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
           LRCDC  QLE  L  +AE    +L+Y  QEGR IG  NKI+AYALQ+QG+DT EAN+ LG
Sbjct: 260 LRCDCHQQLEFFLHFMAENKNCMLIYLDQEGRGIGFANKIKAYALQEQGFDTYEANNLLG 319

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHY 182
           F  D RD+     + +  G+ ++ L T+NP+KV  L + GI I++R+ + +  NP N  Y
Sbjct: 320 FDDDLRDYFDALHILRFFGIKKINLATSNPEKVSFLQDLGIEILKRISIPIVINPYNRKY 379

Query: 183 LDTKAEKMGHLL 194
           + +K  K  H +
Sbjct: 380 IHSKILKKKHEI 391


>UniRef50_A7I3X0 GTP cyclohydrolase-2 n=6 Tax=cellular organisms RepID=RIBA_CAMHC
          Length = 193

 Score =  246 bits (628), Expect = 3e-64,   Method: Composition-based stats.
 Identities = 92/195 (47%), Positives = 124/195 (63%), Gaps = 7/195 (3%)

Query: 1   MQLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDAL 60
           M ++    AKLP+ +G F +  F+E     +H+ ++        PV  R+HSECLTGDA+
Sbjct: 1   MNIEISNVAKLPSRFGMFKVQAFKE--DEKEHLVIIKEPYK--EPVNIRIHSECLTGDAI 56

Query: 61  FSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQ 120
            SL+CDC  QLE +L  I + G G+++Y RQEGRNIGL NKI AY LQD+G DT+EANHQ
Sbjct: 57  GSLKCDCRDQLEESLKFIEKNG-GMVIYLRQEGRNIGLFNKINAYNLQDKGLDTIEANHQ 115

Query: 121 LGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNE 180
           LGF  DER + +   + K   +  + LLTNNPKK+  L    + +  RVP+I+  N  NE
Sbjct: 116 LGFKTDERTYEIVDFILKYYKIKSINLLTNNPKKLMGL--HNVKVAARVPIIIKPNKFNE 173

Query: 181 HYLDTKAEKMGHLLN 195
            YL TK  +MGHLL+
Sbjct: 174 KYLQTKKNEMGHLLD 188


>UniRef50_A0RR75 GTP cyclohydrolase-2 n=10 Tax=Epsilonproteobacteria
           RepID=RIBA_CAMFF
          Length = 195

 Score =  246 bits (628), Expect = 3e-64,   Method: Composition-based stats.
 Identities = 91/196 (46%), Positives = 130/196 (66%), Gaps = 4/196 (2%)

Query: 1   MQLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDAL 60
           M++ +   A LP+ +G F +  ++E     +H+ +   ++     V  R+HSECLTGDA+
Sbjct: 1   MEIIKSNIANLPSRFGKFQIKSYKE-GCCKEHLTIFSPNLDVTKTVNVRIHSECLTGDAI 59

Query: 61  FSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQ 120
            SL+CDC  QLEA+L  I + G G+++Y RQEGRNIGLLNK+ AYALQD G DT+EANHQ
Sbjct: 60  GSLKCDCRDQLEASLKYINKHG-GMVIYLRQEGRNIGLLNKVNAYALQDNGLDTIEANHQ 118

Query: 121 LGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNE 180
           LGF ADER + +   + K  G+  + LLTNNP K+  LT   +NI +R+P+ +  N  N+
Sbjct: 119 LGFKADERTYEIVDFILKDFGIKSINLLTNNPLKLASLTC--VNIEKRIPIEIESNEFNK 176

Query: 181 HYLDTKAEKMGHLLNK 196
            YL  K E+MGH+L++
Sbjct: 177 DYLKVKKEQMGHMLDE 192


>UniRef50_B8H6T8 GTP cyclohydrolase-2 n=1 Tax=Arthrobacter chlorophenolicus A6
           RepID=B8H6T8_ARTCA
          Length = 243

 Score =  246 bits (628), Expect = 4e-64,   Method: Composition-based stats.
 Identities = 94/188 (50%), Positives = 118/188 (62%), Gaps = 3/188 (1%)

Query: 9   AKLPTPWGDFLMVGFEELATGHDHVALVYGDI-SGHTPVLARVHSECLTGDALFSLRCDC 67
            +LPT +GDF+   + +L TG +H+A+   +  S     L R+HSECLTGD   S RCDC
Sbjct: 34  VQLPTAFGDFVAQAWTDLVTGVEHLAVSSPNPPSDGKAPLVRLHSECLTGDVFGSYRCDC 93

Query: 68  GFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAAD 126
           G QL  AL  I E G G LLY R QEGR IGL NKI+AYALQ+ G+DTVEAN QLG   D
Sbjct: 94  GEQLAYALELIHEHG-GTLLYLRGQEGRGIGLANKIKAYALQEAGFDTVEANEQLGLPVD 152

Query: 127 ERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTK 186
            R +   A +   +G++EVRLL+NNP K   L +AG+ +VE VP  V     N  YL TK
Sbjct: 153 ARCYKAAAQVLAEMGLHEVRLLSNNPDKQNRLAKAGVKVVEMVPTEVPSREQNIRYLRTK 212

Query: 187 AEKMGHLL 194
            ++M H L
Sbjct: 213 KDRMEHRL 220


>UniRef50_A4RYG5 Predicted protein n=1 Tax=Ostreococcus lucimarinus CCE9901
           RepID=A4RYG5_OSTLU
          Length = 250

 Score =  245 bits (627), Expect = 5e-64,   Method: Composition-based stats.
 Identities = 84/197 (42%), Positives = 117/197 (59%), Gaps = 4/197 (2%)

Query: 4   KRVAEAKLPTPWGDFLMVGFEE----LATGHDHVALVYGDISGHTPVLARVHSECLTGDA 59
           + VAE KLPT  G + +  +           + V ++YGD+ G   V  RVH  C T + 
Sbjct: 11  RFVAETKLPTDKGFYRVRAYRHANPTTGDVTEPVCVIYGDVEGRENVPVRVHDACFTSEV 70

Query: 60  LFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANH 119
           L S++CDC  QLE A+  I E G GI+ Y +QEGR IGL NKI AYA+Q++G DTV+AN 
Sbjct: 71  LGSMKCDCKQQLEMAMDYIKENGPGIVCYLQQEGRGIGLANKIAAYAVQEEGVDTVDANR 130

Query: 120 QLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNN 179
           +LG   D R++T   +M + L V  V+L+TNNP+K+  L   GI I  R+  +V  N  N
Sbjct: 131 RLGLPDDTREYTAVENMLRELDVRSVQLMTNNPRKIRELECGGIKITGRIACVVKANLFN 190

Query: 180 EHYLDTKAEKMGHLLNK 196
           E YL  K  +M H+L++
Sbjct: 191 EGYLAAKERRMSHVLDQ 207


>UniRef50_B9L8K1 GTP cyclohydrolase-2 n=3 Tax=Bacteria RepID=B9L8K1_NAUPA
          Length = 185

 Score =  245 bits (626), Expect = 6e-64,   Method: Composition-based stats.
 Identities = 101/192 (52%), Positives = 126/192 (65%), Gaps = 7/192 (3%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           +K    A LPT +G F +  F+E     +H+A+    +        R+HSECLTGDAL S
Sbjct: 1   MKISDIATLPTKYGIFKIQSFKE--NDKEHLAIFTEKL--PEIPYIRIHSECLTGDALGS 56

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
           L+CDCG QL  AL  I E G GI+LY RQEGR IGL NK+ AYALQD+G DTVEANHQLG
Sbjct: 57  LKCDCGDQLAFALKTINEHG-GIVLYLRQEGRGIGLFNKVNAYALQDKGLDTVEANHQLG 115

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHY 182
           F AD RDF++   + K  G+ +++LLTNNPKK        I +VER+P+ V  NP NE+Y
Sbjct: 116 FEADMRDFSIVEKILKHFGIKQIKLLTNNPKKEFAFK--NIKVVERIPVKVEPNPYNENY 173

Query: 183 LDTKAEKMGHLL 194
           L TK EK+GH L
Sbjct: 174 LKTKKEKLGHKL 185


>UniRef50_C6V5M6 GTP cyclohydrolase-2 n=2 Tax=Neorickettsia RepID=C6V5M6_NEORI
          Length = 353

 Score =  244 bits (623), Expect = 1e-63,   Method: Composition-based stats.
 Identities = 95/196 (48%), Positives = 126/196 (64%), Gaps = 5/196 (2%)

Query: 2   QLKRVAEAKLPTPWG-DFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDAL 60
            + RV+EAK+      D  MV +  +    +H A++ GD       L RVHS C TGD L
Sbjct: 158 HITRVSEAKIRIRENVDSYMVCYRSIL--KEHYAIIIGDPLSSQEPLVRVHSSCYTGDLL 215

Query: 61  FSLRCDCGFQLEAALTQIAEEG-RGILLYHRQEGRNIGLLNKIRAYALQ-DQGYDTVEAN 118
            SL CDC  QL   + +IAE+   GI+LY  QEGR IGL NKIRAY LQ D+G DTVEAN
Sbjct: 216 GSLSCDCRDQLHDTVKKIAEDPVGGIILYLSQEGRGIGLPNKIRAYNLQEDKGLDTVEAN 275

Query: 119 HQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPN 178
           + LGF  DERDF +   + K LG+ +VRL+TNNP+K+  L+ AG+++  RVP+++  NP 
Sbjct: 276 YCLGFKDDERDFRVVKLILKDLGIQKVRLITNNPEKIRQLSSAGVDVASRVPILMRSNPY 335

Query: 179 NEHYLDTKAEKMGHLL 194
           N  YL TK+EK+GH+ 
Sbjct: 336 NRKYLQTKSEKLGHIF 351


>UniRef50_A5G2C3 GTP cyclohydrolase-2 n=2 Tax=Rhodospirillales RepID=A5G2C3_ACICJ
          Length = 384

 Score =  243 bits (622), Expect = 2e-63,   Method: Composition-based stats.
 Identities = 100/194 (51%), Positives = 133/194 (68%), Gaps = 1/194 (0%)

Query: 3   LKRVAEAKLPTPWG-DFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALF 61
           L RVAE  +P     D  +V F  L  G +H+A++ GD S     L R+HSEC TGD L 
Sbjct: 191 LHRVAEVAVPLDDAPDARLVAFRALDQGIEHMAILVGDPSAQAAPLVRIHSECFTGDLLG 250

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
           SLRCDCG QL+ A+ ++A+EG G++LY  QEGR IGL+NK+RAY LQD+G DTV+AN  L
Sbjct: 251 SLRCDCGPQLKGAIRRMAQEGGGVVLYLAQEGRGIGLINKLRAYTLQDRGLDTVDANRAL 310

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181
           G+ ADER+F + A M   LG++ +RLLTNNP+K   L   G+++VERVP ++  N  N+ 
Sbjct: 311 GWGADERNFHIAAAMLAALGLDHIRLLTNNPEKTAGLAACGVDVVERVPHVIAPNGVNDL 370

Query: 182 YLDTKAEKMGHLLN 195
           YL TKA + GHLL+
Sbjct: 371 YLATKARRFGHLLD 384


>UniRef50_Q17XC9 GTP cyclohydrolase-2 n=13 Tax=Helicobacter RepID=RIBA_HELAH
          Length = 192

 Score =  243 bits (621), Expect = 2e-63,   Method: Composition-based stats.
 Identities = 91/195 (46%), Positives = 128/195 (65%), Gaps = 7/195 (3%)

Query: 2   QLKRVAEAKLPTPWGDFLMVGFEELATG--HDHVALVYGDISGHTPVLARVHSECLTGDA 59
           +L+   +AKLPT +G+F +  F E  +    DH+ +    +      L R+HSECLTGDA
Sbjct: 3   RLEVSNQAKLPTQFGEFYIQCFREKNSNGSKDHLVIF--TLDFPENPLVRLHSECLTGDA 60

Query: 60  LFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANH 119
           L S +CDCG  L+ AL +I++EG G+++Y RQEGR IGL NK+ AYALQD+GYDT++AN 
Sbjct: 61  LGSQKCDCGVALQMALERISKEG-GLVIYLRQEGRGIGLFNKVNAYALQDKGYDTIQANE 119

Query: 120 QLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNN 179
            +GF  DERD+ +  ++ +   + ++RLLTNNPKK+  L +     V R  LIV  N +N
Sbjct: 120 MIGFKDDERDYGIAGEILEYYRIKKMRLLTNNPKKIAALEKY--AEVTRESLIVCANEHN 177

Query: 180 EHYLDTKAEKMGHLL 194
           + YL+ K  KMGHLL
Sbjct: 178 QGYLEVKKLKMGHLL 192


>UniRef50_D0NCB5 Riboflavin biosynthesis protein ribBA, putative n=2
           Tax=Phytophthora infestans T30-4 RepID=D0NCB5_PHYIN
          Length = 367

 Score =  243 bits (620), Expect = 3e-63,   Method: Composition-based stats.
 Identities = 78/193 (40%), Positives = 115/193 (59%), Gaps = 3/193 (1%)

Query: 4   KRVAEAKLPTPWGDFLMVGFE--ELATGHDHVALVYGDISGHTPVLARVHSECLTGDALF 61
             VAE  LPT  G F +  +         + +A++ GD+ G   V  RVH +C T +   
Sbjct: 132 TFVAETALPTDGGMFRVRAYRSVGSLRESEPIAMITGDVRGKRNVPVRVHDQCFTSEVFG 191

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
           SL+CDC  QL+ A     + G G+++Y  QEGR IGL NKI AY++Q++G DTV+AN  L
Sbjct: 192 SLKCDCRDQLDYAKAYTKQHG-GVVIYMPQEGRGIGLANKIMAYSMQERGLDTVDANRVL 250

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181
           GF  D R +     + K LGV  +RLLTNNP+K+ +L++ GI +  R+P+++     ++ 
Sbjct: 251 GFKDDYRSYEPVPAILKDLGVQSIRLLTNNPRKIRLLSQLGITVEGRLPVVIKGGEFSQG 310

Query: 182 YLDTKAEKMGHLL 194
           YL  KA++M HLL
Sbjct: 311 YLTAKAKRMSHLL 323


>UniRef50_B7IF97 A 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase
           II n=1 Tax=Thermosipho africanus TCF52B
           RepID=B7IF97_THEAB
          Length = 374

 Score =  242 bits (619), Expect = 4e-63,   Method: Composition-based stats.
 Identities = 96/189 (50%), Positives = 120/189 (63%), Gaps = 3/189 (1%)

Query: 7   AEAKLPTPWG-DFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRC 65
              KLPT    DF +  F+      +H+A+V        P L R+HSEC TGD   SLRC
Sbjct: 182 TSVKLPTAIDEDFDIYTFKNPYDSREHIAIVKRPFKESIPYL-RIHSECATGDIFHSLRC 240

Query: 66  DCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAA 125
           DCG QLE +L  I+++G G+L+Y RQEGR IGL NK++AY LQD+GYDTVEAN +LGF  
Sbjct: 241 DCGEQLENSLKIISKKG-GVLIYLRQEGRGIGLNNKVKAYKLQDEGYDTVEANLKLGFKD 299

Query: 126 DERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDT 185
           DERD+     + K L +NEV++LTNNPKK E L   GI I E V +    N  N+ YL T
Sbjct: 300 DERDYFAAYLILKALKINEVKILTNNPKKYEDLKRYGIKIKEIVNIYGKVNKYNKKYLFT 359

Query: 186 KAEKMGHLL 194
           KA+KM H L
Sbjct: 360 KAKKMKHNL 368


>UniRef50_Q83FM7 GTP cyclohydrolase-2 n=2 Tax=Tropheryma whipplei RepID=Q83FM7_TROWT
          Length = 211

 Score =  240 bits (612), Expect = 2e-62,   Method: Composition-based stats.
 Identities = 83/193 (43%), Positives = 117/193 (60%), Gaps = 4/193 (2%)

Query: 4   KRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSL 63
           +   E  LPT +G   + G+ ++    +H+AL+   I     VL R+HSEC+TG+   SL
Sbjct: 21  RFEVETNLPTKFGTLRVRGYRDIKNN-EHIALITKQI-KSEDVLLRIHSECITGEVFMSL 78

Query: 64  RCDCGFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
           +CDC  QL  AL +I+ EG G+++Y R  EGR IG+LNK+RAY LQ+QG DT ++N +LG
Sbjct: 79  KCDCHGQLHKALERISAEG-GLVIYMRGHEGRGIGILNKLRAYRLQEQGLDTFDSNVKLG 137

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHY 182
              D RD+   A++   LGV  VRLL+NNP K   L ++GI +   +P  VG    N  Y
Sbjct: 138 LPVDARDYGPAAEILHDLGVRSVRLLSNNPDKQLQLEQSGIRVTGVLPWQVGLGKCNHEY 197

Query: 183 LDTKAEKMGHLLN 195
           L  K +KMGH + 
Sbjct: 198 LKVKRDKMGHKIE 210


>UniRef50_C7NTK7 GTP cyclohydrolase II n=1 Tax=Halorhabdus utahensis DSM 12940
           RepID=C7NTK7_HALUD
          Length = 412

 Score =  238 bits (609), Expect = 5e-62,   Method: Composition-based stats.
 Identities = 101/195 (51%), Positives = 129/195 (66%), Gaps = 6/195 (3%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVY-GDISGHTP-VLARVHSECLTGDAL 60
           + R  + +LPT +G F M G+     G  HVALV   D+   T   L R+HS+CLTGDAL
Sbjct: 217 VSREVDTRLPTAFGTFDMYGY--DYRGETHVALVNLDDVDPETDRPLVRIHSKCLTGDAL 274

Query: 61  FSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQ 120
            SL+CDCGFQLE  + +I++EG G+LLY  QEGR IGLLNK++AY LQ+ GYDTVEAN +
Sbjct: 275 HSLKCDCGFQLEETMQRISDEG-GVLLYLDQEGRGIGLLNKLKAYELQEHGYDTVEANVE 333

Query: 121 LGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNE 180
           LGF  DER F   A M + +G++ VRLLTNNP+K   L     ++ E   L +  NP NE
Sbjct: 334 LGFEPDERRFDAAAQMLRDIGLDRVRLLTNNPRKAAALERFEFDV-EIDSLEIEPNPENE 392

Query: 181 HYLDTKAEKMGHLLN 195
            YL TKAEK+ H L+
Sbjct: 393 AYLATKAEKLDHQLD 407


>UniRef50_A6G7P6 GTP cyclohydrolase-2 n=1 Tax=Plesiocystis pacifica SIR-1
           RepID=A6G7P6_9DELT
          Length = 194

 Score =  238 bits (609), Expect = 6e-62,   Method: Composition-based stats.
 Identities = 94/193 (48%), Positives = 120/193 (62%), Gaps = 1/193 (0%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGH-DHVALVYGDISGHTPVLARVHSECLTGDALF 61
           ++  A AKLP+  GD  +V F        D +A++ GDI+G + V  RVHSECLTGD   
Sbjct: 2   VRVYARAKLPSRHGDLEIVSFTTRDGQRIDDIAIIAGDITGKSAVPTRVHSECLTGDVFG 61

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
           SLRCDC  QLE A+ +I  EG G+++Y RQEGR IG+  K+RAY LQD G DT+EAN  L
Sbjct: 62  SLRCDCRDQLELAIDRICSEGVGLIVYMRQEGRGIGIAEKVRAYELQDSGLDTLEANVHL 121

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181
           GF  D R + + A M + L V+ V L TNNP+KVE L   G+ +  R  +I      N H
Sbjct: 122 GFDGDLRSYEVAASMIQALEVDSVVLFTNNPEKVEGLQANGVEVERREAIISESREENVH 181

Query: 182 YLDTKAEKMGHLL 194
           YL TK  KMGH+L
Sbjct: 182 YLMTKKAKMGHIL 194


>UniRef50_Q1QYD0 GTP cyclohydrolase-2 n=1 Tax=Chromohalobacter salexigens DSM 3043
           RepID=Q1QYD0_CHRSD
          Length = 378

 Score =  238 bits (609), Expect = 6e-62,   Method: Composition-based stats.
 Identities = 91/196 (46%), Positives = 118/196 (60%), Gaps = 2/196 (1%)

Query: 2   QLKRVAEAKLPTPWGD-FLMVGFEELATGHDHVALVYGDISG-HTPVLARVHSECLTGDA 59
            LKR++EA++P    D    V F E     +H+A++ GD +     V  R+HS CLTGD 
Sbjct: 164 SLKRISEAEIPLAEADRTRFVLFRESDGLREHLAVLVGDPAQWADAVPTRLHSACLTGDL 223

Query: 60  LFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANH 119
             SLRCDCG QL  ++  IAE G GILLY  QEGR IGL NK+RAY LQD G DTV+A+ 
Sbjct: 224 FGSLRCDCGEQLRGSVAAIAERGGGILLYLAQEGRGIGLANKLRAYHLQDDGLDTVDADQ 283

Query: 120 QLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNN 179
            LGF  DER + +   M + L V  + LLTNNP K++ ++  G+ +V R       N +N
Sbjct: 284 VLGFGDDERRYHVALQMLEALAVTRIELLTNNPGKIDAMSRGGVEVVGRQACYGKLNEHN 343

Query: 180 EHYLDTKAEKMGHLLN 195
             YL  KAE+ GH LN
Sbjct: 344 RRYLSAKAERAGHWLN 359


>UniRef50_C6X006 GTP cyclohydrolase-2 n=1 Tax=Flavobacteriaceae bacterium 3519-10
           RepID=C6X006_FLAB3
          Length = 204

 Score =  238 bits (607), Expect = 9e-62,   Method: Composition-based stats.
 Identities = 82/194 (42%), Positives = 128/194 (65%), Gaps = 2/194 (1%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELAT-GHDHVALVYGDISGHTPVLARVHSECLTGDALF 61
           LK  AEA +PT +G F ++   E       H+A+V  +     PV  R HSEC+TG+   
Sbjct: 2   LKIQAEANVPTEFGSFRIIALSETDNNWMPHLAIVAENTDFCQPVNVRFHSECITGEVFH 61

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
           S +C+CG QL+AA+  + E G GI++Y RQEGRNIG++NK++AY+LQ++G+DTVEAN +L
Sbjct: 62  SKKCECGQQLDAAMKYMHENG-GIIIYLRQEGRNIGIINKLKAYSLQEKGFDTVEANLEL 120

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181
           G  AD+R+F +  ++  +L V +V LLTNNP+K++++  + I++  R+PL +    ++  
Sbjct: 121 GLPADDRNFAVAVEILNILEVKDVNLLTNNPEKIKVVENSNIHLNSRIPLQISSTTDSAS 180

Query: 182 YLDTKAEKMGHLLN 195
           YL  K +  GH L+
Sbjct: 181 YLKVKKDFFGHFLD 194


>UniRef50_B9ZQZ7 GTP cyclohydrolase-2 n=1 Tax=Thioalkalivibrio sp. K90mix
           RepID=B9ZQZ7_9GAMM
          Length = 381

 Score =  237 bits (605), Expect = 2e-61,   Method: Composition-based stats.
 Identities = 89/198 (44%), Positives = 120/198 (60%), Gaps = 2/198 (1%)

Query: 1   MQLKRVAEAKLPTPWGDF-LMVGFEELATGHDHVALVYGDISG-HTPVLARVHSECLTGD 58
           ++L  V+EA +P         + F E     +HVA+V G+ +     V  R+HS CLTGD
Sbjct: 175 LELAYVSEAPVPLADAPVTRFMLFREGNGILEHVAVVIGEPNEWPDAVPVRLHSACLTGD 234

Query: 59  ALFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEAN 118
              SLRCDCG QL   +  I E G G+LLY  QEGR IGL NK+RAY +Q  G DT++++
Sbjct: 235 LFGSLRCDCGDQLRLGVKTINESGGGVLLYLAQEGRGIGLANKLRAYTMQTAGLDTIDSD 294

Query: 119 HQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPN 178
            QLGF AD R +    +M + LG++ VR+LTNNP K+E L   GI +V R P+    NP+
Sbjct: 295 CQLGFEADGRRYDAAVEMLEFLGIDTVRVLTNNPAKIEALRAGGIRVVAREPVHGTLNPH 354

Query: 179 NEHYLDTKAEKMGHLLNK 196
           N  YL TKA++ GH L +
Sbjct: 355 NLRYLSTKADRGGHWLQE 372


>UniRef50_Q604R2 Riboflavin-specific deaminase/GTP cyclohydrolase II n=1
           Tax=Methylococcus capsulatus RepID=Q604R2_METCA
          Length = 355

 Score =  237 bits (605), Expect = 2e-61,   Method: Composition-based stats.
 Identities = 89/148 (60%), Positives = 103/148 (69%)

Query: 47  LARVHSECLTGDALFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYA 106
           LARVHSECLTGD   S RCDCG QLE AL  I E   G+LLY RQEGR IGL+ K+RAY 
Sbjct: 2   LARVHSECLTGDVFGSRRCDCGEQLELALRAIGEAECGVLLYLRQEGRGIGLVQKLRAYN 61

Query: 107 LQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIV 166
           LQD+G DTVEAN +LG  ADERD+ + A M + LGV  VRL+TNNPKK++ L   GI I 
Sbjct: 62  LQDEGLDTVEANLRLGHQADERDYHVAARMLEDLGVKSVRLMTNNPKKIDELRRYGIPIA 121

Query: 167 ERVPLIVGRNPNNEHYLDTKAEKMGHLL 194
            RVP+    +P N  YL  K EKM H+L
Sbjct: 122 ARVPIEAPSHPENVRYLRAKVEKMSHML 149


>UniRef50_A6W477 GTP cyclohydrolase-2 n=8 Tax=Bacteria RepID=A6W477_KINRD
          Length = 206

 Score =  236 bits (602), Expect = 4e-61,   Method: Composition-based stats.
 Identities = 88/192 (45%), Positives = 106/192 (55%), Gaps = 6/192 (3%)

Query: 9   AKLPTPWGD-----FLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSL 63
             +P  + D       +  F  L  G +H+AL  GD    +  L R HSECLTGD   S 
Sbjct: 13  VDVPLRFADGYGTTARVHTFTGLVDGKEHLALGLGDWRQQSTPLVRPHSECLTGDVFGSE 72

Query: 64  RCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGF 123
           RCDCG QL  A+ +IA  G G LLY RQEGR IGL  K+ AYALQD G DT EAN  LG 
Sbjct: 73  RCDCGPQLREAVERIATTG-GFLLYLRQEGRGIGLYAKLDAYALQDSGLDTYEANLALGR 131

Query: 124 AADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYL 183
             DERD+ + A M   LGV  + LL+NNP K E L   GI +  RVP  V  + +N  YL
Sbjct: 132 GEDERDYAVAAQMLDALGVERIALLSNNPDKAEQLVRHGIAVERRVPTGVHLSASNARYL 191

Query: 184 DTKAEKMGHLLN 195
             K +   H L+
Sbjct: 192 RAKRDHTSHTLD 203


>UniRef50_C4K9I6 GTP cyclohydrolase-2 n=1 Tax=Thauera sp. MZ1T RepID=C4K9I6_THASP
          Length = 385

 Score =  235 bits (601), Expect = 5e-61,   Method: Composition-based stats.
 Identities = 91/196 (46%), Positives = 122/196 (62%), Gaps = 2/196 (1%)

Query: 2   QLKRVAEAKLPTPWGDF-LMVGFEELATGHDHVALVYGDISG-HTPVLARVHSECLTGDA 59
           +L R++EA++P    +    V F E    H+HVA+V G+ +     V  R+HS CLTGD 
Sbjct: 164 RLARISEARVPLAEAENSRFVLFREADGVHEHVAIVIGERANWPEDVPVRLHSSCLTGDL 223

Query: 60  LFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANH 119
             SLRCDCG QL   +  I   G G+LLY  QEGR IGL NK+RAY LQD+G DT++A+ 
Sbjct: 224 FGSLRCDCGEQLRRGVAAIDALGGGVLLYLSQEGRGIGLANKLRAYGLQDEGLDTIDADQ 283

Query: 120 QLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNN 179
            +GF+ DERDF +  +M   LG++ + LLTNNP KV  L +AGI++V R  +       N
Sbjct: 284 VIGFSKDERDFRIAHEMLDELGIDRILLLTNNPSKVAALQKAGIHVVGRRAIYGEVTVQN 343

Query: 180 EHYLDTKAEKMGHLLN 195
           + YL TKA + GH LN
Sbjct: 344 QRYLRTKASRHGHWLN 359


>UniRef50_A6VWW9 GTP cyclohydrolase-2 n=47 Tax=Bacteria RepID=RIBA_MARMS
          Length = 202

 Score =  235 bits (601), Expect = 5e-61,   Method: Composition-based stats.
 Identities = 91/197 (46%), Positives = 120/197 (60%), Gaps = 6/197 (3%)

Query: 3   LKRVAEAKLPTPWGDF--LMVGFEELATGHDHVALVYG---DISGHTPVLARVHSECLTG 57
           L       +P   GD     + F    +G +H+ + +      + ++  L R+HSECLTG
Sbjct: 4   LTIKRRVMIPVRAGDVMAEFISFNGDDSGKEHIGIFFEGTKAKADNSIPLVRLHSECLTG 63

Query: 58  DALFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEA 117
           D   S RCDCG QL+ A+ +I EEG G +LY RQEGR IGL  K+ AYALQDQGYDT +A
Sbjct: 64  DVFGSGRCDCGEQLDEAIDRINEEG-GYILYLRQEGRGIGLYAKLEAYALQDQGYDTYQA 122

Query: 118 NHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNP 177
           N  L    D RDF + A+M + LGV++VRLLTNNP K + L E GI++ E VP  V  N 
Sbjct: 123 NEMLHLPDDGRDFGIAAEMLQALGVSKVRLLTNNPDKAQQLIEHGIDVAELVPTKVHVNQ 182

Query: 178 NNEHYLDTKAEKMGHLL 194
           +N  YL+TKA++  H L
Sbjct: 183 HNRSYLETKAKRKQHTL 199


>UniRef50_UPI000051036D riboflavin-specific deaminase/GTP cyclohydrolase II n=1
           Tax=Brevibacterium linens BL2 RepID=UPI000051036D
          Length = 473

 Score =  235 bits (600), Expect = 7e-61,   Method: Composition-based stats.
 Identities = 89/186 (47%), Positives = 107/186 (57%), Gaps = 3/186 (1%)

Query: 9   AKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCG 68
           +KLPT  G F +  F     G  H  +  GD +     L RVHSECLTGDAL S RCDCG
Sbjct: 19  SKLPTVHGLFTLRTFAH--DGTAHAVMSIGDPALVDAPLVRVHSECLTGDALGSHRCDCG 76

Query: 69  FQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADE 127
            QL A+L  IA+ G GIL+Y R  EGR IGL NK+RAYALQD G DTV AN  L    D 
Sbjct: 77  DQLSASLAAIAQAGDGILIYLRGHEGRGIGLENKLRAYALQDTGLDTVAANRALDLPDDA 136

Query: 128 RDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKA 187
           RD+T  A +   L   ++ LL++NP KV  L   GI + ER  L V   P +  YL+ K 
Sbjct: 137 RDYTGAAAILHDLDCPQITLLSSNPSKVTALEGMGITVAERRDLNVPDRPESAGYLEAKR 196

Query: 188 EKMGHL 193
             M H+
Sbjct: 197 RLMDHI 202


>UniRef50_D2LG53 GTP cyclohydrolase II n=1 Tax=Rhodomicrobium vannielii ATCC 17100
           RepID=D2LG53_RHOVA
          Length = 383

 Score =  235 bits (599), Expect = 7e-61,   Method: Composition-based stats.
 Identities = 87/193 (45%), Positives = 115/193 (59%), Gaps = 1/193 (0%)

Query: 3   LKRVAEAKLPTP-WGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALF 61
           LK V+ A +P    G    V F       D +A++ G+ +   PV  R+HS CLTGD   
Sbjct: 170 LKIVSRAFVPLEGAGSCEFVVFRGGDGFRDQIAILVGNPTPGKPVSVRIHSACLTGDLFG 229

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
           SL+CDCG QL   +  +AEEG G +LY  QEGR  G+ NKIRAY LQDQG+DT +A+  L
Sbjct: 230 SLKCDCGEQLRGTVRAMAEEGGGAVLYLDQEGRGNGIANKIRAYRLQDQGFDTYDADELL 289

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181
           GF  D+R F   ADM +LLG   VRL+TNNP K++ L + G+N++    ++      N  
Sbjct: 290 GFGQDQRRFDFAADMLRLLGFTSVRLMTNNPLKIKALRDGGLNVLSTHRVLTRPTAQNVK 349

Query: 182 YLDTKAEKMGHLL 194
           YL  K +K GHLL
Sbjct: 350 YLAAKRDKAGHLL 362


>UniRef50_Q7VK48 GTP cyclohydrolase-2 n=2 Tax=Helicobacteraceae RepID=RIBA_HELHP
          Length = 194

 Score =  235 bits (599), Expect = 9e-61,   Method: Composition-based stats.
 Identities = 90/198 (45%), Positives = 123/198 (62%), Gaps = 8/198 (4%)

Query: 1   MQLKRVAEAKLPTPWGDFLMVGFEELATGH---DHVALVYGDISGHTPVLARVHSECLTG 57
           M+ +   +AKLPT +G+F    F E    +   +H+ +     +     L R+HSECLTG
Sbjct: 1   MKYEISEQAKLPTRFGNFFTKSFREYGKNNTLFEHLVVF--THTLGETPLVRIHSECLTG 58

Query: 58  DALFSLRCDCGFQLEAALTQIAEE-GRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVE 116
           D   S +CDCG +L  A+ QIA     G+L+Y RQEGR IGL NKI AYALQD+GYDTVE
Sbjct: 59  DVFGSKKCDCGNELALAMEQIAHNTEGGMLIYLRQEGRGIGLFNKINAYALQDKGYDTVE 118

Query: 117 ANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRN 176
           AN QLGFA D R + +  ++FK   +  + LLTNNP+K++ L      +V R  +I   N
Sbjct: 119 ANQQLGFAGDMRSYEIVGEIFKHFHITHINLLTNNPRKIDALAPYA-KVV-RHSIITPSN 176

Query: 177 PNNEHYLDTKAEKMGHLL 194
           P+N+ YL+ K +K+GHLL
Sbjct: 177 PHNQAYLEVKKQKLGHLL 194


>UniRef50_A6DFW0 GTP cyclohydrolase-2 n=1 Tax=Lentisphaera araneosa HTCC2155
           RepID=A6DFW0_9BACT
          Length = 361

 Score =  233 bits (596), Expect = 2e-60,   Method: Composition-based stats.
 Identities = 75/194 (38%), Positives = 104/194 (53%), Gaps = 2/194 (1%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHT-PVLARVHSECLTGDALF 61
           ++     +L    G F +  F        H A V  +        L R+ SECLTG    
Sbjct: 168 IEMTGMTELDLQQGSFKLYSFYSEIDARYHWAFVCDEKKEEKKTPLVRIESECLTGHVFG 227

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQD-QGYDTVEANHQ 120
           SL CDCG QL   L +I E G G L+Y RQEGR IGL  K+ AY LQ   G DTV+AN  
Sbjct: 228 SLLCDCGDQLSKGLEEIKEYGYGALVYLRQEGRGIGLKAKLDAYYLQQFHGMDTVDANIA 287

Query: 121 LGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNE 180
           +G   D RD+ + A +   L    ++LLTNNP K+  L   G+++ ++V  I+  + +N+
Sbjct: 288 VGMPEDARDYLIGAQIINYLKFEPLKLLTNNPAKITGLNRYGLSVEQQVSHIIPPSKHNK 347

Query: 181 HYLDTKAEKMGHLL 194
            YLDTK ++MGH +
Sbjct: 348 RYLDTKRDRMGHRI 361


>UniRef50_B2GGU5 GTP cyclohydrolase-2 n=1 Tax=Kocuria rhizophila DC2201
           RepID=B2GGU5_KOCRD
          Length = 238

 Score =  233 bits (595), Expect = 3e-60,   Method: Composition-based stats.
 Identities = 86/200 (43%), Positives = 109/200 (54%), Gaps = 8/200 (4%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATG----HDHVALVYGDISGHT--PVLARVHSECLT 56
           L+      +PT  G F +VG+           +HV+L     +G      L R+HSECLT
Sbjct: 32  LEHSEPVTVPTDHGTFSVVGWRVPERSGAPATEHVSLSAPPPAGEEKLAPLVRLHSECLT 91

Query: 57  GDALFSLRCDCGFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTV 115
           GD   S RCDCG QL  AL +I   G G +LY R  EGR IGL+NK+RAY LQD G DTV
Sbjct: 92  GDVFGSWRCDCGPQLHLALERIHTHG-GTVLYLRNHEGRGIGLVNKLRAYKLQDAGADTV 150

Query: 116 EANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGR 175
           +AN  LG  A+ RD+T  A +   + +  VRLLTNNP KV  L   GI + + +   V  
Sbjct: 151 DANTMLGLPAEARDYTAAARILTAMNLTTVRLLTNNPDKVSKLEALGITVADVLAHEVSP 210

Query: 176 NPNNEHYLDTKAEKMGHLLN 195
              N  YL TK ++M H L 
Sbjct: 211 RTENVDYLRTKRDRMHHHLT 230


>UniRef50_D2NTM1 GTP cyclohydrolase II n=2 Tax=Rothia mucilaginosa
           RepID=D2NTM1_9MICC
          Length = 278

 Score =  233 bits (594), Expect = 4e-60,   Method: Composition-based stats.
 Identities = 88/202 (43%), Positives = 115/202 (56%), Gaps = 10/202 (4%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISG-------HTPVLARVHSECL 55
           ++   E  +PTP G F +  +   A G +H++    D  G          +  R+HSEC 
Sbjct: 78  VESTEEVAVPTPQGLFGLRAWRF-ADGAEHISARALDRDGTPVPAEDGGALAVRIHSECA 136

Query: 56  TGDALFSLRCDCGFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDT 114
           TGD   S RCDCG QLE  L  I   G G L+Y R  EGR IGL+NK+RAYALQD G DT
Sbjct: 137 TGDIFGSFRCDCGPQLENGLRIIGRTG-GYLIYVRNHEGRGIGLVNKLRAYALQDAGLDT 195

Query: 115 VEANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVG 174
           ++AN  LG   D RD++  A + + LGVNE+RL+TNNP K E L   G+ + E +P  + 
Sbjct: 196 LDANLALGLDGDMRDYSQAALILQELGVNELRLVTNNPAKQEALESLGLQVTELIPDEIP 255

Query: 175 RNPNNEHYLDTKAEKMGHLLNK 196
               N HYL TK E+M H+L  
Sbjct: 256 ARVENAHYLQTKRERMRHVLKS 277


>UniRef50_A1SSA8 GTP cyclohydrolase-2 n=10 Tax=Gammaproteobacteria RepID=RIBA_PSYIN
          Length = 200

 Score =  232 bits (591), Expect = 7e-60,   Method: Composition-based stats.
 Identities = 84/196 (42%), Positives = 118/196 (60%), Gaps = 7/196 (3%)

Query: 1   MQLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTP-VLARVHSECLTGDA 59
           + LK  A +++P       +  F  L +  +H+A+++G     +   + R+HSECLTGD 
Sbjct: 8   ISLKIGANSRIPA-----QIASFNGLTSDKEHIAIIFGKADECSSSPIVRIHSECLTGDV 62

Query: 60  LFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANH 119
             S RCDCG QL+ A+  + +EG GI++Y RQEGR IGL NKI AY LQ +G DT +AN+
Sbjct: 63  FHSSRCDCGEQLDEAIELMEKEG-GIIIYLRQEGRGIGLYNKIDAYKLQSEGMDTYQANN 121

Query: 120 QLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNN 179
           QLGF  D RDFT    M   L + +++LLTNNP KV+ L E GI + + +        +N
Sbjct: 122 QLGFEDDLRDFTEAGQMLAALNIRKLQLLTNNPLKVKALREYGITVDKVISTSTFIKDDN 181

Query: 180 EHYLDTKAEKMGHLLN 195
           E YL TKA+  GH + 
Sbjct: 182 ESYLRTKAKNAGHAIR 197


>UniRef50_Q03XZ0 GTP cyclohydrolase II n=1 Tax=Leuconostoc mesenteroides subsp.
           mesenteroides ATCC 8293 RepID=Q03XZ0_LEUMM
          Length = 397

 Score =  229 bits (584), Expect = 4e-59,   Method: Composition-based stats.
 Identities = 85/184 (46%), Positives = 113/184 (61%), Gaps = 2/184 (1%)

Query: 11  LPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQ 70
           LPT +GDF +  F         + L+    S     L R+HSECLTG+   S RC+CG Q
Sbjct: 216 LPTQYGDFHLTEFSVNDEEKSDL-LIQSSRSFDQIPLVRLHSECLTGEIFGSQRCECGPQ 274

Query: 71  LEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDF 130
           L  AL  I ++G G L+Y RQEGR IGL  K+++Y LQ+  +DT +AN  LG   DERD+
Sbjct: 275 LREALKTINKQG-GALVYLRQEGRGIGLHEKLKSYVLQENKFDTYDANVHLGHLPDERDY 333

Query: 131 TLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAEKM 190
              A + K+ G+ ++RLLTNNP KV+ L + GI ++E+VPLI G N  NE Y+ TK EK 
Sbjct: 334 KKAAKILKISGLTKIRLLTNNPDKVQSLIDEGIEVIEQVPLITGINDKNEQYMQTKKEKF 393

Query: 191 GHLL 194
            H L
Sbjct: 394 NHKL 397


>UniRef50_B3CNI0 GTP cyclohydrolase-2 n=13 Tax=Wolbachia RepID=B3CNI0_WOLPP
          Length = 361

 Score =  228 bits (582), Expect = 8e-59,   Method: Composition-based stats.
 Identities = 77/180 (42%), Positives = 111/180 (61%), Gaps = 1/180 (0%)

Query: 17  DFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALT 76
           +  ++ +   + G +H A++ G+       L R+HS C TGD L SL CDC  QL  A+ 
Sbjct: 180 EVDIISYRTKSGGREHYAIIIGNPDKDNEPLVRIHSACYTGDLLDSLSCDCRSQLHQAIQ 239

Query: 77  QIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQ-GYDTVEANHQLGFAADERDFTLCAD 135
            + + G GI+LY  Q+GR IGL NK+RAY++Q +   DTV+AN  LGF  DER F + A 
Sbjct: 240 IMTDFGNGIILYLMQDGRGIGLTNKLRAYSMQRKYNLDTVDANRVLGFEDDERSFAVAAK 299

Query: 136 MFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAEKMGHLLN 195
           + K L +N+++LLTNN +K+  L   GI + + VPLI+ RN  N  Y++TK  K+GH L 
Sbjct: 300 ILKKLNINKIQLLTNNGRKLSELKNNGIEVTKCVPLIMERNEYNHSYMETKFGKLGHGLR 359


>UniRef50_C7R1D1 3,4-dihydroxy-2-butanone 4-phosphate synthase n=1 Tax=Jonesia
           denitrificans DSM 20603 RepID=C7R1D1_JONDD
          Length = 411

 Score =  227 bits (579), Expect = 2e-58,   Method: Composition-based stats.
 Identities = 80/191 (41%), Positives = 101/191 (52%), Gaps = 5/191 (2%)

Query: 10  KLPTPWGDFLMVGFEELA---TGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCD 66
            +PTP G   +  +          +H+ L             RVHSECLTGD   S RCD
Sbjct: 221 TMPTPHGSTTVQAWRFTTPRGDVVEHLTLSTWAPDMGVIPDVRVHSECLTGDVFASQRCD 280

Query: 67  CGFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAA 125
           CG QL+ AL  IA    GI++Y R  EGR IGL +KIRAY LQD+GYDTV+AN  LGFA 
Sbjct: 281 CGEQLDRALMHIATH-PGIVVYLRGHEGRGIGLFDKIRAYHLQDEGYDTVDANTALGFAP 339

Query: 126 DERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDT 185
           D+R +   A +   LG + V LLTNNP K   L   G+ +     + +     N  Y+ T
Sbjct: 340 DQRTWEHAAAILTALGASTVNLLTNNPAKQHGLEAHGVTVQGTTRIELPTTIYNADYMRT 399

Query: 186 KAEKMGHLLNK 196
           K  +M H LN 
Sbjct: 400 KKTRMDHQLNN 410


>UniRef50_C6QGG9 GTP cyclohydrolase-2 n=1 Tax=Hyphomicrobium denitrificans ATCC
           51888 RepID=C6QGG9_9RHIZ
          Length = 213

 Score =  227 bits (578), Expect = 2e-58,   Method: Composition-based stats.
 Identities = 82/196 (41%), Positives = 112/196 (57%), Gaps = 9/196 (4%)

Query: 8   EAKLPTPWG----DFLMVGFEELATGHDHVALVYGDIS----GHTPVLARVHSECLTGDA 59
           E  LP  +           ++        V LV+ D           + R+HS C+TGD 
Sbjct: 18  ETILPIEFQGREITLEAHAYQGETDAEQMVVLVHRDPDVANGSAAIPVVRIHSGCVTGDI 77

Query: 60  LFSLRCDCGFQLEAALTQIAEEGRGILLYH-RQEGRNIGLLNKIRAYALQDQGYDTVEAN 118
             SLRCDC  QL+AAL  I E   G+++Y    EGR IGL  KI+AYALQDQG DTVEAN
Sbjct: 78  FHSLRCDCYQQLQAALKAITEVPLGVIVYAPYHEGRGIGLFKKIQAYALQDQGLDTVEAN 137

Query: 119 HQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPN 178
            ++G   D RD++L A + + LG+ E++LL+NNP K + L   GI + ER+PL++  N  
Sbjct: 138 IEVGAPIDSRDYSLAARVLQDLGMPEIKLLSNNPAKEQALKAHGIRVAERLPLVIKPNKF 197

Query: 179 NEHYLDTKAEKMGHLL 194
           N+ YL+TK  +M H L
Sbjct: 198 NKRYLETKRARMAHKL 213


>UniRef50_A5ARE3 Putative uncharacterized protein n=1 Tax=Vitis vinifera
           RepID=A5ARE3_VITVI
          Length = 480

 Score =  224 bits (572), Expect = 1e-57,   Method: Composition-based stats.
 Identities = 67/192 (34%), Positives = 100/192 (52%), Gaps = 40/192 (20%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           ++R A ++LPT WG F    +     G +HVA+V                          
Sbjct: 322 VERTAISRLPTKWGLFQAYCYRSKLDGTEHVAIV-------------------------- 355

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
                          + + GRG+++Y R  EGR IGL +K+RAY LQD+G+DTVEAN +L
Sbjct: 356 -------------KLVEQAGRGVVVYLRGHEGRGIGLGHKLRAYNLQDEGHDTVEANLEL 402

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181
           G A D R++ + A + + +GV  ++L+TNNP K   L   G+ +V RVP++      N+ 
Sbjct: 403 GLAVDAREYGIGAQILRDIGVRTMQLMTNNPAKFTGLKGYGLAVVGRVPVLTPITEENKK 462

Query: 182 YLDTKAEKMGHL 193
           YL+TK  KMGH+
Sbjct: 463 YLETKRTKMGHI 474


>UniRef50_Q87D69 GTP cyclohydrolase-2 n=22 Tax=Proteobacteria RepID=RIBA_XYLFT
          Length = 398

 Score =  222 bits (566), Expect = 5e-57,   Method: Composition-based stats.
 Identities = 81/195 (41%), Positives = 108/195 (55%), Gaps = 1/195 (0%)

Query: 2   QLKRVAEAKLPTPW-GDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDAL 60
           + + V    +P    G    + F       D VA++ G     + V  RVHS CLTGD  
Sbjct: 172 EYELVTRTPVPLRDLGMSEFIVFRGGIAQRDQVAILIGRPDLSSAVPVRVHSSCLTGDLF 231

Query: 61  FSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQ 120
            SL+CDCG QL  +L  +   G G+LLY  QEGR  G+  KIRAY  Q  G DT++A+ Q
Sbjct: 232 GSLKCDCGDQLRHSLATLKALGGGVLLYLDQEGRGNGIAAKIRAYGYQHVGLDTIDADAQ 291

Query: 121 LGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNE 180
           LGF  DER +T    M + LG+  ++LL+NNP K E L  AGI + +R+ +I      NE
Sbjct: 292 LGFGPDERRYTGAVMMLRALGITRIQLLSNNPAKAERLRAAGIIVKQRISVIGQITKQNE 351

Query: 181 HYLDTKAEKMGHLLN 195
           HYL TK  + GH L+
Sbjct: 352 HYLRTKVSRAGHDLD 366


>UniRef50_Q4V1U4 GTP cyclohydrolase-2 n=26 Tax=Bacillus cereus group
           RepID=Q4V1U4_BACCZ
          Length = 245

 Score =  213 bits (544), Expect = 2e-54,   Method: Composition-based stats.
 Identities = 79/170 (46%), Positives = 97/170 (57%), Gaps = 1/170 (0%)

Query: 25  ELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQIAEEGRG 84
            LA       LVYGD       L R+HS C TGD   S RCDCGFQL+ +L  I E G G
Sbjct: 69  NLADMQQSSVLVYGDFENSEDALIRMHSICHTGDIFGSKRCDCGFQLKQSLQMITEHGSG 128

Query: 85  ILLYH-RQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVN 143
            L Y    EGR IGL +K   Y LQ+ G DTVEAN  LGF  D R++    ++ K L   
Sbjct: 129 ALFYLANHEGRGIGLFSKAMTYLLQENGLDTVEANLNLGFEDDVRNYDDTIEVLKALRSK 188

Query: 144 EVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAEKMGHL 193
            V+L+TNNPKK+E L +AG+N+  R PL    +  NE YL TK ++ GH 
Sbjct: 189 PVKLITNNPKKLEALQKAGLNVTSREPLWGDVSEFNEKYLQTKIQRSGHF 238


>UniRef50_P51618 GTP cyclohydrolase-2 n=63 Tax=Gammaproteobacteria RepID=RIBA_PHOPO
          Length = 200

 Score =  213 bits (542), Expect = 3e-54,   Method: Composition-based stats.
 Identities = 87/178 (48%), Positives = 110/178 (61%), Gaps = 2/178 (1%)

Query: 19  LMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQI 78
            ++ F  L +G +H+AL++ D       L R+HSECLTGD   S RCDCG QL+  +  +
Sbjct: 21  ELLSFNGLESGKEHIALIFKDAYKAFVPLVRMHSECLTGDGFHSTRCDCGEQLDETIEIM 80

Query: 79  AEEGRGILLYHRQEGR-NIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMF 137
           AE G GI+LY RQEGR  +GL NKI AY LQ QG DT EAN+ LGF  D R+F+  A M 
Sbjct: 81  AELG-GIILYLRQEGRWGLGLYNKIDAYKLQSQGMDTYEANNHLGFDDDLREFSEAAQML 139

Query: 138 KLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAEKMGHLLN 195
             LG+ ++RL+TNNPKK++ L + GINIVE V         NE YL  KA    H  N
Sbjct: 140 TALGIKDIRLVTNNPKKIKDLQQNGINIVEVVGTKAHLKEGNEGYLKAKASHGRHCFN 197


>UniRef50_A8FIW0 GTP cyclohydrolase-2 n=7 Tax=Bacillales RepID=A8FIW0_BACP2
          Length = 253

 Score =  213 bits (542), Expect = 4e-54,   Method: Composition-based stats.
 Identities = 76/171 (44%), Positives = 97/171 (56%), Gaps = 1/171 (0%)

Query: 24  EELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQIAEEGR 83
            +LA       LVYGD       L R+HS C TGD   S RCDCGFQL+ ++  I + G 
Sbjct: 71  RQLADHQQSSVLVYGDFEHADEALIRMHSICHTGDIFGSKRCDCGFQLKQSMRMIEDNGA 130

Query: 84  GILLYH-RQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGV 142
           G L Y    EGR IGL  K  AY LQ+ GYDTVEAN  LGF  D R +     + + L  
Sbjct: 131 GALFYLANHEGRGIGLFTKAMAYILQENGYDTVEANEALGFEDDTRQYEEAIAVLQTLRT 190

Query: 143 NEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAEKMGHL 193
             VRL+TNNPKK + ++ AG+++  R+PL    +  NE YL TK  + GH+
Sbjct: 191 KPVRLITNNPKKTDAISHAGLSLSGRIPLWGDVSEFNEKYLQTKINRSGHM 241


>UniRef50_Q3YT81 GTP cyclohydrolase-2 n=6 Tax=canis group RepID=Q3YT81_EHRCJ
          Length = 380

 Score =  212 bits (541), Expect = 5e-54,   Method: Composition-based stats.
 Identities = 71/176 (40%), Positives = 105/176 (59%), Gaps = 2/176 (1%)

Query: 19  LMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQI 78
            +  +       DH A++ G+     P+  R+HS C TGD L SL CDC  QL  A+  +
Sbjct: 191 KIKVYRSYTGELDHYAIIIGNPDYSNPI-VRIHSSCYTGDLLNSLSCDCRCQLHTAIKLM 249

Query: 79  AEEGRGILLYHRQEGRNIGLLNKIRAYALQ-DQGYDTVEANHQLGFAADERDFTLCADMF 137
            E   GI+LY  Q+GR IGL NKIR Y LQ    +DTV+AN   GF  DER FT    + 
Sbjct: 250 TENKGGIILYLAQDGRGIGLANKIRTYQLQTKHNFDTVDANRFFGFEDDERVFTPAIKIL 309

Query: 138 KLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAEKMGHL 193
           + LG++ ++LLTNNP K+  + +  I + + +P+ V  N +N +Y++TKA+++GH+
Sbjct: 310 QKLGISRLQLLTNNPNKISEIQKNNIQVTKILPIFVDTNQHNINYINTKAKRLGHV 365


>UniRef50_C5AMM6 GTP cyclohydrolase-2 n=2 Tax=Burkholderia glumae RepID=C5AMM6_BURGB
          Length = 252

 Score =  212 bits (540), Expect = 7e-54,   Method: Composition-based stats.
 Identities = 87/177 (49%), Positives = 101/177 (57%), Gaps = 4/177 (2%)

Query: 19  LMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQI 78
            MV F  L    +H+ALV+G I      L R+HSECLTGD   S RCDCG QL+ ++   
Sbjct: 72  EMVTFNGLCDSAEHIALVFGKI--GEAPLVRLHSECLTGDVFGSARCDCGEQLDESIALF 129

Query: 79  AEEGRGILLYHRQEGRNIGLLNKIRAYALQ-DQGYDTVEANHQLGFAADERDFTLCADMF 137
            E G GILLY RQEGR IGL NK+ AY LQ  QG DT  AN  L F  D RDF + A M 
Sbjct: 130 GERG-GILLYLRQEGRGIGLYNKLDAYRLQISQGLDTFAANRALNFPDDLRDFRVAAQML 188

Query: 138 KLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAEKMGHLL 194
           K LGV EV L+TNNP K   LT  GI + +     V  N  N  YL  KA +  H +
Sbjct: 189 KALGVGEVSLVTNNPDKTAQLTRHGIKVRQVKSTGVFANSVNFGYLHAKATQHRHAI 245


>UniRef50_C9S9H3 GTP cyclohydrolase-2 n=1 Tax=Verticillium albo-atrum VaMs.102
           RepID=C9S9H3_VERA1
          Length = 379

 Score =  210 bits (535), Expect = 2e-53,   Method: Composition-based stats.
 Identities = 81/240 (33%), Positives = 112/240 (46%), Gaps = 45/240 (18%)

Query: 2   QLKRVAEAKLPTPWGDFL-MVGFEELATGHDH-----------------VALVYG----- 38
           +++ +  A++PT  G  + +  +        H                 +A   G     
Sbjct: 135 KVQCIVRARIPTVAGTEMFLHLYTGRDRDGPHGPGAYTGRLFPGRTTSGMASGTGSTPDS 194

Query: 39  ---------DISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQI---AEEGRGIL 86
                      +   P L R+HSEC TG+  +S RCDCG QL+ A   +        GI+
Sbjct: 195 ASKEQGEEAPPAPTGPPLVRIHSECYTGETAWSARCDCGEQLDEAARLMSLPGNHNGGII 254

Query: 87  LYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNEVR 146
           +Y RQEGR IGL  K++AY LQD G DTVEAN  L   AD R + L   M   LG +EVR
Sbjct: 255 IYLRQEGRGIGLGEKLKAYNLQDLGSDTVEANLLLRHPADARSYGLATAMLLDLGQDEVR 314

Query: 147 LLTNNPKKVEILTEAG--INIVERVPLIVGR--------NPNNEHYLDTKAEKMGHLLNK 196
           LLTNNP K+  +      + + ERV ++           +   E YL TK EKMGH+L+ 
Sbjct: 315 LLTNNPDKIRAVEGPNREVRVRERVAMVPLSWKGKGGFKSEEVEGYLKTKIEKMGHMLDS 374


>UniRef50_B9KHB1 GTP cyclohydrolase-2 n=5 Tax=Anaplasma RepID=B9KHB1_ANAMF
          Length = 377

 Score =  209 bits (532), Expect = 5e-53,   Method: Composition-based stats.
 Identities = 73/176 (41%), Positives = 102/176 (57%), Gaps = 2/176 (1%)

Query: 19  LMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQI 78
            ++ +       +H A++ GD S   PV  R+HS C TGD L S+ CDC  QL   +  +
Sbjct: 202 KILVYRSNLGEPEHYAIIIGDPSFENPV-VRLHSSCYTGDLLGSISCDCRGQLLHTIQFL 260

Query: 79  AEEGRGILLYHRQEGRNIGLLNKIRAYALQ-DQGYDTVEANHQLGFAADERDFTLCADMF 137
                GI+LY  QEGR IGL NKIRAY LQ     DTV+AN  LGF  DER F   A + 
Sbjct: 261 GSGSGGIVLYISQEGRGIGLANKIRAYNLQTQNALDTVDANRFLGFDDDERVFLPAARIL 320

Query: 138 KLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAEKMGHL 193
             LG+++ ++LT+NP KV  + + G  + + +PL VG +  N  Y+ TK E++GH+
Sbjct: 321 DELGISKFQMLTSNPSKVSSMCDHGFTVTKMIPLSVGTHERNIDYIKTKIERLGHV 376


>UniRef50_B0UFT4 GTP cyclohydrolase-2 n=4 Tax=Rhizobiales RepID=B0UFT4_METS4
          Length = 370

 Score =  208 bits (530), Expect = 9e-53,   Method: Composition-based stats.
 Identities = 87/194 (44%), Positives = 108/194 (55%), Gaps = 1/194 (0%)

Query: 3   LKRVAEAKLPTPWG-DFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALF 61
           L+ V+ A +P     +   V F       D VA+V G      PV  RVHS CLTGD   
Sbjct: 165 LQIVSRAPVPLDGAPETEFVVFRGGEGLRDQVAVVIGRPDPAQPVAVRVHSACLTGDLFG 224

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
           SL+CDCG QL      +A+ G GI+LY  QEGR  GL NKIRAYALQ +GYDT  A+  L
Sbjct: 225 SLKCDCGDQLRGTAKWMAQNGGGIILYLDQEGRGNGLANKIRAYALQAKGYDTYAADEML 284

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181
           GF  D+R F   A M + LGV  VR+L+NNP+KV  L  AG+ +V     +    P N  
Sbjct: 285 GFGLDQRRFDFAAAMLRCLGVASVRVLSNNPEKVAALAAAGLAVVGEQRALGRVTPENAR 344

Query: 182 YLDTKAEKMGHLLN 195
           YL  K +  GH L+
Sbjct: 345 YLAAKRDVAGHALD 358


>UniRef50_Q14FW6 Riboflavin biosynthesis protein ribA/GTP-cyclohydrolase II n=20
           Tax=Proteobacteria RepID=Q14FW6_FRAT1
          Length = 403

 Score =  208 bits (529), Expect = 1e-52,   Method: Composition-based stats.
 Identities = 73/194 (37%), Positives = 104/194 (53%), Gaps = 6/194 (3%)

Query: 3   LKRVAEAKLP-TPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALF 61
           + ++A + +P    G+  M  +++  +G + V L           L R+HS C+TGD   
Sbjct: 211 VTKMASSTIPFKKIGELEMSVYKDNFSGDEVVVLSK--PYSGNNPLVRMHSSCITGDIFG 268

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQ-DQGYDTVEANHQ 120
           SLRCDC  QL   +  I+EEG G  +Y  QEGR IGL NK++AY LQ ++  DT+EAN  
Sbjct: 269 SLRCDCQDQLHKGIEMISEEG-GFFIYLDQEGRGIGLTNKLKAYNLQMNENMDTLEANLA 327

Query: 121 LGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNE 180
           LG  AD R + L   + K   VN  RL++NNP+K+  L    I   + V      N +N 
Sbjct: 328 LGLPADARKYDLAIQVLKYNNVNRCRLISNNPEKLAALRNVDIE-TQPVYCEAFVNSHNR 386

Query: 181 HYLDTKAEKMGHLL 194
           +YL TK  K  H +
Sbjct: 387 NYLITKKIKAKHTI 400


>UniRef50_P50139 GTP cyclohydrolase-2 n=33 Tax=Ascomycota RepID=RIB1_PICGU
          Length = 332

 Score =  205 bits (522), Expect = 7e-52,   Method: Composition-based stats.
 Identities = 75/166 (45%), Positives = 99/166 (59%), Gaps = 10/166 (6%)

Query: 41  SGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLN 100
               P+LAR+HSEC TG+  +S RCDCG Q + A   + E G G ++Y RQEGR IGL  
Sbjct: 163 CSGEPILARIHSECYTGETAWSARCDCGEQFDEAGRLMGEAGHGCIVYLRQEGRGIGLGE 222

Query: 101 KIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTE 160
           K++AY LQD G DTV+AN  L   AD R F+L   +   LG+NE++LLTNNP K+  +  
Sbjct: 223 KLKAYNLQDLGADTVQANLMLRHPADARSFSLATAILLDLGLNEIKLLTNNPDKIAAVEG 282

Query: 161 AG--INIVERVPLIVGR--------NPNNEHYLDTKAEKMGHLLNK 196
               + +VERVP++           +   E YL  K E+MGHLL K
Sbjct: 283 RNREVKVVERVPMVPLAWRSENGIKSKEIEGYLSAKIERMGHLLEK 328


>UniRef50_B8KSW9 GTP cyclohydrolase-2 n=1 Tax=gamma proteobacterium NOR51-B
           RepID=B8KSW9_9GAMM
          Length = 273

 Score =  201 bits (513), Expect = 9e-51,   Method: Composition-based stats.
 Identities = 74/166 (44%), Positives = 95/166 (57%), Gaps = 4/166 (2%)

Query: 34  ALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQIA-EEGRGILLYHR-Q 91
            LV G+       L RVHS CLTGD   S RC+CG QLEAA+ +IA +E  G L+Y    
Sbjct: 103 VLVIGEPEKSEAPLVRVHSSCLTGDVFGSRRCECGPQLEAAIDRIATDEQGGYLIYMAGH 162

Query: 92  EGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGV-NEVRLLTN 150
           EGR IGL  K   Y LQD G DT +AN  LG   D RDF+  A +    G   ++RL+TN
Sbjct: 163 EGRGIGLWAKAATYLLQDAGEDTYQANRSLGLPDDSRDFSDAATLLHYFGAGRKLRLMTN 222

Query: 151 NPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAEKMGHLLNK 196
           NPKK+E L   G+  +ERV  + G +  N  YL  K  + GH +++
Sbjct: 223 NPKKIEDLRAFGVPNLERVKHVSGVDDCNLRYLQAKR-QWGHRIDE 267


>UniRef50_A8NX34 GTP cyclohydrolase-2 n=2 Tax=Agaricales RepID=A8NX34_COPC7
          Length = 468

 Score =  200 bits (509), Expect = 2e-50,   Method: Composition-based stats.
 Identities = 83/198 (41%), Positives = 104/198 (52%), Gaps = 43/198 (21%)

Query: 40  ISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQIAEE------GRGILLYHRQEG 93
            S   P L R+HSEC TG+ + S+RCDCG QL+ A+ QI+        GRG ++Y RQEG
Sbjct: 260 PSDLPPPLIRIHSECFTGETVGSMRCDCGEQLDEAIRQISNPINSQIPGRGAVIYLRQEG 319

Query: 94  RNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVN---------E 144
           R IGLL+KIRAY LQD G+DTV AN  LG  ADER + +   + K LG+           
Sbjct: 320 RGIGLLSKIRAYNLQDMGHDTVTANLMLGHKADERGYEIAGAILKDLGLGCGENASCSES 379

Query: 145 VRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNE------------------------ 180
           VR+LTNNP K+E L + GI I ERVP+I                                
Sbjct: 380 VRILTNNPDKMEALRKEGIQISERVPMIPRSWQQRSQTEETVVKQETLGLTLIGGKAVHG 439

Query: 181 ----HYLDTKAEKMGHLL 194
                YL TK  +MGH+L
Sbjct: 440 DDLDKYLRTKVVRMGHML 457



 Score = 47.9 bits (113), Expect = 2e-04,   Method: Composition-based stats.
 Identities = 14/57 (24%), Positives = 26/57 (45%), Gaps = 2/57 (3%)

Query: 1   MQLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGD--ISGHTPVLARVHSECL 55
           +Q+K +A  ++PTP G   +  +       +H+A+V     +    P L  + S  L
Sbjct: 162 LQVKCMARTRIPTPHGPAFLHLYHNNRDNKEHLAIVVDPSQLDQSAPSLPPIRSRSL 218


>UniRef50_P38066 GTP cyclohydrolase-2 n=8 Tax=Saccharomycetales RepID=RIB1_YEAST
          Length = 345

 Score =  199 bits (506), Expect = 5e-50,   Method: Composition-based stats.
 Identities = 78/194 (40%), Positives = 104/194 (53%), Gaps = 21/194 (10%)

Query: 24  EELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQIAE--- 80
           E   +  + +A        H   L R+HSEC TG+  +S RCDCG Q + A   IA    
Sbjct: 118 EFDDSTGELLASKATTWDAHNDTLVRIHSECYTGENAWSARCDCGEQFDRAGRLIACDHE 177

Query: 81  --------EGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTL 132
                    G G+++Y RQEGR IGL  K++AY LQD G DTV+AN  L    D RDF+L
Sbjct: 178 PTSNIKGGNGHGVIVYLRQEGRGIGLGEKLKAYNLQDLGADTVQANLMLKHPVDARDFSL 237

Query: 133 CADMFKLLGVNEVRLLTNNPKKVEILTEAG-INIVERVPLIVGR---------NPNNEHY 182
              +   LG+  VRLLTNNP+K++ +  A  +  VERVP++            +   E Y
Sbjct: 238 GKAILLDLGIGNVRLLTNNPEKIKQVDHAPYLKCVERVPMVPIHWTNSSEGIDSKEIEGY 297

Query: 183 LDTKAEKMGHLLNK 196
           L TK E+MGHLL +
Sbjct: 298 LRTKIERMGHLLTE 311


>UniRef50_A0Z3E0 GTP cyclohydrolase-2 n=1 Tax=marine gamma proteobacterium HTCC2080
           RepID=A0Z3E0_9GAMM
          Length = 272

 Score =  196 bits (500), Expect = 2e-49,   Method: Composition-based stats.
 Identities = 76/166 (45%), Positives = 96/166 (57%), Gaps = 4/166 (2%)

Query: 34  ALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQIAEE-GRGILLYHR-Q 91
            L  GD       L RVHS CLTGD   S RC+CG QLEAA+ ++AEE G G L+Y    
Sbjct: 103 VLAIGDAETTESPLVRVHSNCLTGDVFGSRRCECGPQLEAAIDRLAEEPGGGYLIYMAGH 162

Query: 92  EGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNE-VRLLTN 150
           EGR IGL  K   Y LQD+G DT +AN  LG   D RDF+  A + K  G    +RLLTN
Sbjct: 163 EGRGIGLWAKAATYLLQDEGEDTYQANRSLGLPDDSRDFSDAATLLKYFGRGRPLRLLTN 222

Query: 151 NPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAEKMGHLLNK 196
           NPKK++ L   G+  +ERV  + G + +N  YL  K    GH +++
Sbjct: 223 NPKKIDDLLANGLTNIERVKHVTGVDDHNLRYLKAKQA-WGHSIDE 267


>UniRef50_C9PF77 GTP cyclohydrolase II n=1 Tax=Vibrio furnissii CIP 102972
           RepID=C9PF77_VIBFU
          Length = 352

 Score =  196 bits (499), Expect = 3e-49,   Method: Composition-based stats.
 Identities = 69/189 (36%), Positives = 101/189 (53%), Gaps = 9/189 (4%)

Query: 9   AKLPTPWGDFLMVGFEELATGHDHV-ALVYGDISG-HTPVLARVHSECLTGDALFSLRCD 66
            +LPT  G F M       TG++    + +GDIS   +  + R+HS CL  +   +  CD
Sbjct: 7   CELPTLHGTFRMY-----DTGNELFRVVTFGDISNLGSQPMVRIHSSCLASEVFEARDCD 61

Query: 67  CGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRA-YALQDQGYDTVEANHQLGFAA 125
           C  QL  A+  +A +G GI+ +  QEGR  GL  KI+A Y +Q +  DT E+   +G   
Sbjct: 62  CADQLREAMKAMAHDGSGIIFHLHQEGRGQGLSKKIQAVYKMQVEALDTAESFQAMGLEQ 121

Query: 126 DERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDT 185
           D RD+     + K + + EVRL++NNP+K   L +AGI + E V       P N  YL +
Sbjct: 122 DIRDYEPAISVLKKMAIEEVRLVSNNPRKRSALEQAGIAV-EVVNTHPQVRPENAGYLQS 180

Query: 186 KAEKMGHLL 194
           K +K+GH L
Sbjct: 181 KNDKLGHYL 189


>UniRef50_C5LSF0 GTP cyclohydrolase II, putative (Fragment) n=1 Tax=Perkinsus
           marinus ATCC 50983 RepID=C5LSF0_9ALVE
          Length = 406

 Score =  196 bits (498), Expect = 4e-49,   Method: Composition-based stats.
 Identities = 77/196 (39%), Positives = 108/196 (55%), Gaps = 10/196 (5%)

Query: 5   RVAEAKLPTPWGDFL----MVGFEELAT-GHDHVALVYGDISGHTPVLARVHSECLTGDA 59
           +++  ++P     +     +  +   +    + V L+ G + G + V  R+HSEC TGD 
Sbjct: 211 QLSSCRVPLHHLRYTSHCDLRVYRGCSDPSLELVTLIKGKVEGESNVPVRIHSECFTGDV 270

Query: 60  LFSLRCDCGFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQ-GYDTVEA 117
           L S++CDCG QL   L  + EE R +LLY R  EGR IGL NK++AY LQD+ G DT+E+
Sbjct: 271 LRSMKCDCGDQLLDFLVTLDEEERAVLLYIRGHEGRGIGLANKVKAYNLQDEDGLDTIES 330

Query: 118 NHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNP 177
           N +LG+A D RDF       + LG++ V L TNNP KV  L +    + E   +    N 
Sbjct: 331 NIRLGYAPDCRDFADARRALRHLGIHSVMLYTNNPAKVAALGDM---VAEVKAVPARPNR 387

Query: 178 NNEHYLDTKAEKMGHL 193
           NN  YL TK  K  HL
Sbjct: 388 NNIGYLRTKQSKFHHL 403


>UniRef50_C0A9J6 GTP cyclohydrolase-2 n=1 Tax=Opitutaceae bacterium TAV2
           RepID=C0A9J6_9BACT
          Length = 516

 Score =  195 bits (496), Expect = 7e-49,   Method: Composition-based stats.
 Identities = 74/195 (37%), Positives = 99/195 (50%), Gaps = 5/195 (2%)

Query: 6   VAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRC 65
           +A   L T +G F    F+++   H  +AL +GDI G T +  R+HS C+T + L    C
Sbjct: 40  LATCALDTRYGAFRAYVFQDITDKHYILALTHGDICGATTLHTRLHSSCVTSETLRGCDC 99

Query: 66  DCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYD---TVEANHQLG 122
           DC  QLE A   IA++G GIL Y  QEGR +G   K R   L     D   T +A   +G
Sbjct: 100 DCTQQLEGAFKVIAQKGSGILFYLMQEGRGVGYFAKARDRMLVQASQDQLSTFDAYAAMG 159

Query: 123 FAADERDFTLCADMFKLLGVN-EVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181
            A D R++   + +  LLG+     LLTNNP K+E L   G+ I    PL     P N  
Sbjct: 160 LAKDHRNYENISHICHLLGIRASFILLTNNPDKIEALRAQGLPIAGSEPLEFEPGPFNLA 219

Query: 182 YLDTKAEKMGHLLNK 196
           YL +KA   GH L +
Sbjct: 220 YLTSKAAN-GHQLQR 233



 Score = 85.2 bits (210), Expect = 1e-15,   Method: Composition-based stats.
 Identities = 31/158 (19%), Positives = 61/158 (38%), Gaps = 11/158 (6%)

Query: 18  FLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQ 77
           F +  + ++ T  D V L +G  +     + R+HS     +       D   +L+ A+  
Sbjct: 348 FRVHAYYDIVTNQDWVVLTHGTPTPDDAPVVRLHS-DSIFNRFPLRTTDNRAKLKQAVKH 406

Query: 78  IAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTV--EANHQLGFAADERDFTLCAD 135
           I   G G++L    +GR  G         + + G  +   +A   L    D RD+     
Sbjct: 407 IVTYGSGVMLLLHNDGRGAGFGAHATDRMMTEAGAVSTSDDAYRLLAVGYDSRDYDAAIM 466

Query: 136 MF-KLLGVNEVRLLTNNPKKV-------EILTEAGINI 165
           +    L    ++++ N+P+ +       E L    I++
Sbjct: 467 LLRHHLPSERIQMVMNSPESLVKKPEYAEALNRHHIDV 504


>UniRef50_Q5KNS2 GTP cyclohydrolase-2 n=1 Tax=Filobasidiella neoformans
           RepID=Q5KNS2_CRYNE
          Length = 550

 Score =  193 bits (491), Expect = 3e-48,   Method: Composition-based stats.
 Identities = 82/231 (35%), Positives = 108/231 (46%), Gaps = 77/231 (33%)

Query: 42  GHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQIAEE-------------------- 81
                L R+HSEC TG+ + S+RCDCG QL+ A+ QIAE                     
Sbjct: 315 QDIKPLVRIHSECFTGETIGSMRCDCGEQLDEAIHQIAEPQRIPVPLVAPNSYSGDSFST 374

Query: 82  ---------------GRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAAD 126
                          GRG+++Y RQEGR IGLL KIRAY LQD G+DTV AN  LG  AD
Sbjct: 375 SAAFHPETTAYTHVPGRGVVIYLRQEGRGIGLLEKIRAYNLQDLGHDTVTANLMLGHGAD 434

Query: 127 ERDFTLCADMFKLLGVNE--VRLLTNNPKKVEILTEAGINIVERVPLIVGRN-------- 176
           ER + + A++ + LG+ +  +RLLTNNP+KV  L   G+ +VERV +             
Sbjct: 435 ERKYDIAAEILRDLGLADEGIRLLTNNPEKVRGLAREGVKVVERVGMTPRSWQCGDDHSH 494

Query: 177 --------------------------------PNNEHYLDTKAEKMGHLLN 195
                                           P  E YL TK E+MGH+++
Sbjct: 495 ENKDGAKEEKEYEDWRMRRAGVGLIGAGMASGPELEKYLRTKVERMGHIID 545



 Score = 45.6 bits (107), Expect = 0.001,   Method: Composition-based stats.
 Identities = 11/53 (20%), Positives = 25/53 (47%)

Query: 1   MQLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSE 53
           +Q++ +A  ++P+P G+  +  +       +H+A++   I     V A   S 
Sbjct: 210 IQVRCMARTRIPSPHGELFLHLYHNSYDAKEHLAILLDPIQLDAEVRAAAPSS 262


>UniRef50_A6MYZ0 GTP cyclohydrolase-2 n=2 Tax=Saccharomycetaceae RepID=A6MYZ0_9SACH
          Length = 313

 Score =  193 bits (490), Expect = 4e-48,   Method: Composition-based stats.
 Identities = 77/178 (43%), Positives = 99/178 (55%), Gaps = 16/178 (8%)

Query: 34  ALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEG 93
           A    D  G T  L R+HSEC TG+  +S RCDCG Q + A   I E G G+++Y RQEG
Sbjct: 103 AGTTWDEDGDTGTLVRLHSECYTGETAWSARCDCGEQFDRAGRMIGESGSGVIVYLRQEG 162

Query: 94  RNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPK 153
           R IGL  K++AY LQD G DTV+AN  L    D RDF+L   +   LG+  VRLLTNNP+
Sbjct: 163 RGIGLGEKLKAYNLQDLGADTVQANLLLKHPVDGRDFSLGRAILVDLGIKSVRLLTNNPQ 222

Query: 154 KVEIL-TEAGINIVERVPLIVGR---------------NPNNEHYLDTKAEKMGHLLN 195
           K++ +     +  VERVP+I                  +   + YL  K E+MGHLL 
Sbjct: 223 KLQQVHCPPLLTCVERVPMIPLSWIDGVREAGXEVGIRSKEVDAYLRVKMEQMGHLLQ 280


>UniRef50_Q4P4Y7 GTP cyclohydrolase-2 n=2 Tax=Basidiomycota RepID=Q4P4Y7_USTMA
          Length = 776

 Score =  192 bits (489), Expect = 5e-48,   Method: Composition-based stats.
 Identities = 67/148 (45%), Positives = 90/148 (60%), Gaps = 16/148 (10%)

Query: 45  PVLARVHSECLTGDALFSLRCDCGFQLEAALTQIAEE----------------GRGILLY 88
             L R+HSEC TG+ + S RCDCG QL+ A+  I+E                 GRG+++Y
Sbjct: 450 APLVRIHSECFTGETIGSQRCDCGEQLDEAIRLISEAYDTSKPRDPGAAQQKLGRGVIVY 509

Query: 89  HRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNEVRLL 148
            RQEGR IGLL+K+ AY LQD G+DTV AN  LG   D R + + + + K LGV+E RLL
Sbjct: 510 LRQEGRGIGLLDKLMAYNLQDMGHDTVSANILLGHLPDARKYDIASAILKDLGVDECRLL 569

Query: 149 TNNPKKVEILTEAGINIVERVPLIVGRN 176
           TNNP+K+E L   G+ + ERV ++    
Sbjct: 570 TNNPEKMEALEAEGVRVAERVGMVPRVW 597



 Score = 46.7 bits (110), Expect = 4e-04,   Method: Composition-based stats.
 Identities = 8/45 (17%), Positives = 20/45 (44%)

Query: 1   MQLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTP 45
           ++++  A  ++PTP G+     ++      +H+A+V         
Sbjct: 327 VRVRCYARTRVPTPHGEVFCHLYKNTHDTKEHLAIVIDPYQNDEA 371


>UniRef50_A8FAX3 GTP cyclohydrolase-2 n=2 Tax=Bacillus pumilus RepID=A8FAX3_BACP2
          Length = 241

 Score =  191 bits (487), Expect = 9e-48,   Method: Composition-based stats.
 Identities = 66/164 (40%), Positives = 95/164 (57%), Gaps = 4/164 (2%)

Query: 35  LVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQIAEEGRGILLYH-RQEG 93
           L++GD     P L R+HS C TGD   SL+CDCG QL  +L +I + G+G+L+Y   QEG
Sbjct: 74  LLFGDFENEMPPLVRIHSVCQTGDVFGSLKCDCGPQLALSLKKITDYGKGMLVYMANQEG 133

Query: 94  RNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNE-VRLLTNNP 152
           R+IGL+ K   Y LQ+   DT EAN  +G   D+R +   A +   L   + + LLTNNP
Sbjct: 134 RSIGLMAKALTYKLQEMQLDTFEANRLIGCGDDDRHYEEAAAVLHYLNKGKPMHLLTNNP 193

Query: 153 KKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAEKMGHLLNK 196
            KV+ +   G+ ++ R    V  +  NE YL  KA   GH++++
Sbjct: 194 DKVDSIAAYGLPVL-RFDHTVEASLYNEAYLKAKAA-SGHMVDE 235


>UniRef50_D0L7U8 3,4-dihydroxy-2-butanone 4-phosphate synthase n=1 Tax=Gordonia
           bronchialis DSM 43247 RepID=D0L7U8_GORB4
          Length = 418

 Score =  190 bits (484), Expect = 2e-47,   Method: Composition-based stats.
 Identities = 70/203 (34%), Positives = 104/203 (51%), Gaps = 13/203 (6%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPV----LARVHSECLTGD 58
           + +VA A +PT +GDF  V +     G +H+AL+ GD++  +      L RVHSECLTGD
Sbjct: 215 VAQVASAAMPTAFGDFRAVAYRCELDGTEHLALLMGDLAAASRTDRGALVRVHSECLTGD 274

Query: 59  ALFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEAN 118
            L SLRCDCG QLE AL+ IAEEG G ++Y R   R  G + + R+   + +   +  + 
Sbjct: 275 ILGSLRCDCGSQLEQALSAIAEEGCGAVVYLRGM-RAAGSVWRTRSAPTRCRNRVSTPST 333

Query: 119 HQLGFAADERDFTLCAD--MFKLLGVNEVRLLTNNP---KKVEILTEAGINIVERVPLIV 173
               +      +   A   + +    +E     ++P   +K   L    + IV R  L  
Sbjct: 334 PTPRWGC---RWIPAATVWVLRSSPTSEPGGSASSPTTRQKYGGLEGFDLEIVGRFGLPT 390

Query: 174 GRNPNNEHYLDTKAEKMGHLLNK 196
              P+N  YL TK E+MGH L++
Sbjct: 391 VITPHNVRYLRTKQERMGHTLDQ 413


>UniRef50_Q2S6L1 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
           n=5 Tax=Bacteria RepID=Q2S6L1_SALRD
          Length = 415

 Score =  188 bits (478), Expect = 8e-47,   Method: Composition-based stats.
 Identities = 66/186 (35%), Positives = 99/186 (53%), Gaps = 10/186 (5%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           ++R AE  L T +G F +V +EE  TG  H+AL+ GD +   PVL RVHS+ + GD L +
Sbjct: 219 IERAAEVDLDTAFGTFQVVAYEETLTGDVHLALLKGDWAEDEPVLVRVHSQNVLGDVLAA 278

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRA---YALQDQGYDTVEANH 119
            R     +L  AL Q+  EG G +LY  Q     GLL+K++    +  QD G     A  
Sbjct: 279 RRESYSEELAEALLQVEHEGTGAILYMMQSNHGQGLLSKLKDLERHQNQDDG-----APT 333

Query: 120 QLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNN 179
            +    D RD+ +   + + LG+ ++RLLTNNP+K   L   G+ +VE+ P+ +      
Sbjct: 334 DVSLEMDHRDYGIGCQILRDLGIRKLRLLTNNPRKRIGLAGYGLELVEQTPIELP--TEA 391

Query: 180 EHYLDT 185
             +L T
Sbjct: 392 RDHLST 397


>UniRef50_A1SF04 GTP cyclohydrolase-2 n=16 Tax=Bacteria RepID=A1SF04_NOCSJ
          Length = 215

 Score =  186 bits (472), Expect = 5e-46,   Method: Composition-based stats.
 Identities = 72/173 (41%), Positives = 93/173 (53%), Gaps = 3/173 (1%)

Query: 19  LMVGFEELATGHDHVALVYGDISG--HTPVLARVHSECLTGDALFSLRCDCGFQLEAALT 76
            +  F  L    +H+ +  G          L R+HSECLTGD   S RCDCG QL+ AL 
Sbjct: 30  RVHTFTGLPGAEEHLVVAVGPYRRPRGGVPLVRLHSECLTGDVFGSRRCDCGPQLDEALV 89

Query: 77  QIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADM 136
           +IAE G G L+Y RQEGR IGL  K+ AY LQDQG DT EAN  LG+  D R + +   M
Sbjct: 90  RIAEHG-GYLVYLRQEGRGIGLYAKLDAYRLQDQGLDTFEANRALGYPEDARGYEVAGRM 148

Query: 137 FKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAEK 189
            + L V +V L+T NP+K   L   G+ +   +P  +     N  YL  K  +
Sbjct: 149 LRALDVLQVDLMTGNPQKAAGLAAGGVAVRRTLPTALHETTENLRYLHAKRRR 201


>UniRef50_A8PZB1 GTP cyclohydrolase-2 n=1 Tax=Malassezia globosa CBS 7966
           RepID=A8PZB1_MALGO
          Length = 455

 Score =  178 bits (453), Expect = 7e-44,   Method: Composition-based stats.
 Identities = 62/144 (43%), Positives = 83/144 (57%), Gaps = 11/144 (7%)

Query: 46  VLARVHSECLTGDALFSLRCDCGFQLEAALTQIAEEGRGILL-----------YHRQEGR 94
            L R+HSEC TG+ + S RCDCG QL+ AL  I                    Y RQEGR
Sbjct: 167 PLVRIHSECYTGETIGSQRCDCGEQLDEALRIIGTSSSRTATGVPVPPRGVVVYMRQEGR 226

Query: 95  NIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKK 154
            IGLL+K+ AY LQD G+DTV AN  LG   D R + + + + + LG+++ RLLTNNP+K
Sbjct: 227 GIGLLDKLLAYNLQDMGHDTVSANVLLGHLPDARRYDISSAILRDLGIDQCRLLTNNPEK 286

Query: 155 VEILTEAGINIVERVPLIVGRNPN 178
           ++ L   GI + ERVP++      
Sbjct: 287 MQALEAEGIRVTERVPMVPRIWQF 310



 Score = 45.2 bits (106), Expect = 0.001,   Method: Composition-based stats.
 Identities = 8/39 (20%), Positives = 18/39 (46%)

Query: 1  MQLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGD 39
          ++++     ++PTP G+     +       +H+ALV   
Sbjct: 53 LEVRCYGRTRVPTPHGEVFCHLYRNNHDNKEHMALVIDP 91


>UniRef50_C5RMY3 GTP cyclohydrolase-2 n=1 Tax=Clostridium cellulovorans 743B
           RepID=C5RMY3_CLOCL
          Length = 175

 Score =  177 bits (449), Expect = 2e-43,   Method: Composition-based stats.
 Identities = 61/167 (36%), Positives = 90/167 (53%), Gaps = 1/167 (0%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           LK+      PT +  F    F         V  +  D      +L R+HSEC   + L S
Sbjct: 6   LKKSEIFTFPTEYALFKAQVFILKDGTMPVVVSLNQDHLSLNDILVRIHSECFMSEVLSS 65

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQ-GYDTVEANHQL 121
           +RCDC  QL+ +L +IA EG+G+L Y RQEG+ +GL NK +AY LQ++      EA+   
Sbjct: 66  IRCDCASQLKESLKRIASEGQGVLFYLRQEGKGMGLFNKAKAYYLQEKYQLSNYEADKMA 125

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVER 168
           GF  D RD+    ++   + ++ +RLLTNN +K+  L E GIN+ + 
Sbjct: 126 GFPEDTRDYAFVVEVLNEMNIHSIRLLTNNDEKIRYLKENGINVQKT 172


>UniRef50_Q0D0K3 GTP cyclohydrolase-2 n=29 Tax=Leotiomyceta RepID=Q0D0K3_ASPTN
          Length = 447

 Score =  176 bits (446), Expect = 4e-43,   Method: Composition-based stats.
 Identities = 66/185 (35%), Positives = 85/185 (45%), Gaps = 37/185 (20%)

Query: 41  SGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALTQIA-------------------EE 81
                 L R+HSEC TG+  +S RCDCG QL+ A   ++                     
Sbjct: 225 HPSQAPLVRIHSECYTGETAWSARCDCGEQLDEAARLMSLPMETLAEVASQQSRTVPSNA 284

Query: 82  GRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLG 141
             G+++Y RQEGR IGL  K++AY LQD G DTVEAN  L   AD R + L   M   LG
Sbjct: 285 SGGVIIYLRQEGRGIGLGEKLKAYNLQDLGSDTVEANLLLRHPADARSYGLATAMLVDLG 344

Query: 142 V------NEVRLLTNNPKKVEILTEAGINIV--ERVPLIVGRNP----------NNEHYL 183
           +      + +RLLTNNP KV  +      +V  ERV ++                 E YL
Sbjct: 345 LGVDANPHGIRLLTNNPDKVRAVEGPNREVVVKERVAMVPLAWKTGGKMGIKSSEVEGYL 404

Query: 184 DTKAE 188
            TK  
Sbjct: 405 RTKVR 409



 Score = 42.1 bits (98), Expect = 0.012,   Method: Composition-based stats.
 Identities = 8/39 (20%), Positives = 22/39 (56%), Gaps = 1/39 (2%)

Query: 2   QLKRVAEAKLPTPWG-DFLMVGFEELATGHDHVALVYGD 39
           +++ +  A++PT  G +  +  +       +H+A+V+G+
Sbjct: 115 KVECIVRARIPTTNGAEMFLHLYHNDLDNKEHLAIVFGN 153


>UniRef50_A0SNY3 Riboflavin biosynthesis protein RibA n=2 Tax=Candidatus
           Micrarchaeum acidiphilum ARMAN-2 RepID=A0SNY3_9EURY
          Length = 290

 Score =  173 bits (440), Expect = 2e-42,   Method: Composition-based stats.
 Identities = 63/215 (29%), Positives = 101/215 (46%), Gaps = 20/215 (9%)

Query: 1   MQLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPV-------LARVHSE 53
           +Q+ R+    + TP+G F    FE      ++  LV   +             L R+ S 
Sbjct: 74  VQVTRLGLGPIDTPFGKFYEFEFEVGDRWKEYNVLVKAGLDDKFNPQFEDGKILVRMDSA 133

Query: 54  CLTGDALFSLRCDCGFQLEAALTQIAEEGRGILLYH-RQEGRNIGLLNKIRAYALQDQ-G 111
           C TG       CDC  QL  A+ +I + G G++++  +Q+GR +GL  K+    LQD+ G
Sbjct: 134 CKTGQLFHDKTCDCKLQLLKAMHEIEKNGSGMIVHMPKQDGRGMGLSFKLGTLMLQDELG 193

Query: 112 YDTVEANHQLG-------FAADERDFTLCADMFKLLGVNE---VRLLTNNPKKVEILTEA 161
           Y+TVEA   L         A D R +     + +  G++    + + TNNPKK++   E 
Sbjct: 194 YNTVEAAAALKSMEFIEPEALDPRTYGGVIAILRFFGIDSGFDINVATNNPKKIQAFQEN 253

Query: 162 GINIVERVPLIVGRNPNNEHYLDTKAEKMGHLLNK 196
           G ++  R P+I+  N   + +LD K E   H L +
Sbjct: 254 GYDV-GRTPVIIPPNEYTKRHLDAKEETFHHDLRR 287


>UniRef50_Q5YVN1 GTP cyclohydrolase-2 n=1 Tax=Nocardia farcinica RepID=Q5YVN1_NOCFA
          Length = 256

 Score =  173 bits (439), Expect = 3e-42,   Method: Composition-based stats.
 Identities = 73/187 (39%), Positives = 94/187 (50%), Gaps = 6/187 (3%)

Query: 13  TPWG-DFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQL 71
           T  G +  +   E  A       LV+G+I      L R+HS CL GDAL S  CDCG +L
Sbjct: 15  TRKGAELTVRVRELPADRDGGSVLVFGEI--GQDCLVRIHSRCLYGDALQSDDCDCGPEL 72

Query: 72  EAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQ-GYDTVEANHQLGFAADERDF 130
           E ++  I  EGRG+L+Y  QEGR  GL+ K R     ++ G DT  A  +LG+  D R F
Sbjct: 73  ERSMDLIQAEGRGVLVYLDQEGRGAGLVAKARGLREAERTGADTFTAYTRLGYPEDARSF 132

Query: 131 TLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGR-NPNNEHYLDTKAEK 189
            L A     LG+  VRLLTNNP K   LT+ G+ +   VPL     +     YL  K   
Sbjct: 133 RLAAAAIAELGLRRVRLLTNNPDKAAALTDLGVAVT-VVPLTTRPRSARARKYLQDKRAH 191

Query: 190 MGHLLNK 196
             H L +
Sbjct: 192 RRHWLPE 198


>UniRef50_Q6KH48 GTP cyclohydrolase-2 n=1 Tax=Mycoplasma mobile RepID=Q6KH48_MYCMO
          Length = 343

 Score =  166 bits (420), Expect = 5e-40,   Method: Composition-based stats.
 Identities = 61/184 (33%), Positives = 98/184 (53%), Gaps = 4/184 (2%)

Query: 11  LPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQ 70
           + T  G F M  FE  +   + V    GD+     V AR+H +C+T +   S+ CDC  Q
Sbjct: 162 METSDGFFNMKSFEVPSHNKEFVIKWNGDLKK--IVNARIHYKCMTSEVFGSIMCDCKDQ 219

Query: 71  LEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAY-ALQDQGYDTVEANHQLGFAADERD 129
           LE+    + +EG G+LLY  +EGR  G+L+K+ AY   + +G DTV+A  +     + R 
Sbjct: 220 LESFNELMKKEG-GLLLYAYEEGRGFGMLHKLNAYYNTEKEGLDTVDAMIKETGKTEARK 278

Query: 130 FTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEHYLDTKAEK 189
           F +  ++ + LG+ EV L TNNP+K+  L +  I +  +      ++   + Y + K +K
Sbjct: 279 FDMAGEIIRKLGIKEVNLYTNNPRKIIPLLDRRIKVNRKKHWTETKSKEAKKYTEDKIKK 338

Query: 190 MGHL 193
           M HL
Sbjct: 339 MEHL 342


>UniRef50_Q08VV8 GTP cyclohydrolase-2 n=1 Tax=Stigmatella aurantiaca DW4/3-1
           RepID=Q08VV8_STIAU
          Length = 356

 Score =  163 bits (413), Expect = 3e-39,   Method: Composition-based stats.
 Identities = 64/150 (42%), Positives = 75/150 (50%), Gaps = 5/150 (3%)

Query: 49  RVHSECLTGDALFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQ 108
           R+HS C+T +A     CDC  QLE AL +IAE GRG + Y  QEGR  G   K R   L 
Sbjct: 2   RIHSACITSEAFGGCDCDCAEQLELALERIAEAGRGAVFYLMQEGRGAGYAAKARDRMLV 61

Query: 109 DQGYDTV---EANHQLGFAADERDFTLCADMFKLLGVN-EVRLLTNNPKKVEILTEAGIN 164
               DTV   EA   LG   D R +   A    LL V   VRLLTNNP+K   L   GI 
Sbjct: 62  QASCDTVSTFEAYRMLGLEPDSRRYHEVALALGLLKVRAPVRLLTNNPEKTRALKTLGIE 121

Query: 165 IVERVPLIVGRNPNNEHYLDTKAEKMGHLL 194
           +     +    NP N HYL +K  + GH L
Sbjct: 122 VEAAERIQREANPFNVHYLSSKR-REGHAL 150


>UniRef50_A2TRN2 GTP cyclohydrolase-2 n=1 Tax=Dokdonia donghaensis MED134
           RepID=A2TRN2_9FLAO
          Length = 170

 Score =  159 bits (403), Expect = 4e-38,   Method: Composition-based stats.
 Identities = 56/170 (32%), Positives = 88/170 (51%), Gaps = 2/170 (1%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           + ++A+  + T +G +  + F +     +  ALV GDISG   VL RVHS C+      S
Sbjct: 2   IVQLADGTIKTKYGIYKEILFYDGI--KESHALVMGDISGEEDVLCRVHSSCIFAHHFNS 59

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
           + CDC  Q+E +   I   G+GI+++  QEG+  G    +    L+ +G    +A   +G
Sbjct: 60  IECDCREQMEISQQLIERAGKGIVIWLEQEGKGNGHYALLNTLPLKKEGMPQADAYEAVG 119

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLI 172
           F  D RDF+  A + K L VN + ++T N KK + LT+ GI +    P  
Sbjct: 120 FHKDNRDFSAAAKILKHLEVNSITMITGNEKKTKTLTDLGIRVSGIQPTE 169


>UniRef50_A9QS81 GTP cyclohydrolase-2 n=1 Tax=Lactococcus lactis subsp. lactis KF147
           RepID=A9QS81_LACLK
          Length = 209

 Score =  155 bits (393), Expect = 7e-37,   Method: Composition-based stats.
 Identities = 61/197 (30%), Positives = 90/197 (45%), Gaps = 7/197 (3%)

Query: 2   QLKRVAEAKLPTPWGDFLMVGFEELATGH--DHVALVY-GDISGHTPVLARVHSECLTGD 58
           ++ +V++ +L    G F +  F     G   +H ALV   D      V  R++S C+T +
Sbjct: 9   KILKVSKGQLEIKNGVFTLYAFMIYYEGRCEEHYALVNSKDWKIDEAVPFRINSACVTSE 68

Query: 59  ALFSLRCDCGFQLEAALTQIAEEGRGILLYH-RQEGRNIGLLNKIRAYALQDQGYDTVEA 117
                +CDC +QL+ A+  I E G GI+ YH   EG   G+  K+ ++   + G D    
Sbjct: 69  VFGCEKCDCKWQLDEAIHYITEIGFGIITYHPNHEGLGHGIFEKLNSFN--ELGADNTSY 126

Query: 118 NHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIV-GRN 176
                   D R+F     +     +NEV LL NN KK+  L E G+NI   V LI  G N
Sbjct: 127 IDLNCEKEDARNFLPALIILDYFKINEVTLLGNNLKKIHFLMENGVNISGIVNLIYNGNN 186

Query: 177 PNNEHYLDTKAEKMGHL 193
              + Y+  K  K  H 
Sbjct: 187 RTTKKYILLKGRKPEHF 203


>UniRef50_B5JMM0 3,4-dihydroxy-2-butanone 4-phosphate synthase family n=1
           Tax=Verrucomicrobiae bacterium DG1235 RepID=B5JMM0_9BACT
          Length = 360

 Score =  145 bits (367), Expect = 6e-34,   Method: Composition-based stats.
 Identities = 47/169 (27%), Positives = 74/169 (43%), Gaps = 21/169 (12%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           ++ + E    +  G+F M  F  L  G +HVALV G+I      L RVH+E +  D    
Sbjct: 213 VELIREQPFSSVHGEFSMKVFRSLLDGREHVALVAGEIC-SETTLVRVHAENVVKDLFHP 271

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
                   +  A+ +IAEEG G ++Y R+ G  +                    AN    
Sbjct: 272 SDAGAEDSIGLAMKRIAEEGCGAIVYIRRPGGGL--------------------ANSPED 311

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPL 171
            +   R++ + A +   LG+ ++RLL+   + V  L   G+ IVE V L
Sbjct: 312 KSMGLREYGIGAQILSSLGLQKIRLLSQTNRNVIALDGYGLEIVETVGL 360


>UniRef50_C0YN89 3,4-dihydroxy-2-butanone-4-phosphate synthase n=1
           Tax=Chryseobacterium gleum ATCC 35910 RepID=C0YN89_9FLAO
          Length = 373

 Score =  145 bits (366), Expect = 8e-34,   Method: Composition-based stats.
 Identities = 43/169 (25%), Positives = 72/169 (42%), Gaps = 5/169 (2%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           ++R+ E K+ T +GDF    F E +    H AL  G  +   PVL RV S     D L  
Sbjct: 210 VERIEERKVKTFYGDFDFYAFRETSNEQIHFALTKGAWTVDEPVLVRVQSSDSYFDVLTR 269

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
           L       LE     + E G+G +++      +   L K++ +     G +         
Sbjct: 270 LNNGEKPLLEKVTNMVNEAGKGAIIFINNVSNSENTLRKLQQFLNYQDGQE-----QHPT 324

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPL 171
            A + RD+ +   + K LG+N+ +++T NP     +    + + E V L
Sbjct: 325 LAYNYRDYGIGTQILKNLGINKFKVITQNPNIKPQVGGYDVEVTEMVQL 373


>UniRef50_Q6MIV8 GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate
           synthase n=1 Tax=Bdellovibrio bacteriovorus
           RepID=Q6MIV8_BDEBA
          Length = 376

 Score =  144 bits (365), Expect = 1e-33,   Method: Composition-based stats.
 Identities = 46/171 (26%), Positives = 77/171 (45%), Gaps = 9/171 (5%)

Query: 3   LKRVAEAKLPTPWGDF-LMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALF 61
           ++ +    LP  +G+      F     G +H+ +  G+I    P L RVH +  T D + 
Sbjct: 208 VEELHSVPLPASFGENMQARVFRSTVDGLEHLVIQKGEIKKDHPTLVRVHVDNFTRDFMA 267

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
            ++      LE ++  I++E  G  +  R   R  GL  ++        G + +     L
Sbjct: 268 VVQRGASSVLE-SIKAISQEESGAFVLLRGNNRTSGLTQELNVLV----GLEDIRPTTPL 322

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLI 172
               DERD+ + A + + +G N++RLLTN P+K   L    I IVE V + 
Sbjct: 323 ---MDERDYGIGAQILREIGANKIRLLTNKPEKKVGLKAFDIEIVEIVAME 370


>UniRef50_A0SNY4 Riboflavin biosynthesis protein RibA n=2 Tax=Candidatus
           Micrarchaeum acidiphilum ARMAN-2 RepID=A0SNY4_9EURY
          Length = 251

 Score =  144 bits (363), Expect = 2e-33,   Method: Composition-based stats.
 Identities = 51/206 (24%), Positives = 91/206 (44%), Gaps = 17/206 (8%)

Query: 1   MQLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGD---------ISGHTPVLARVH 51
            +++R+A   + T +G+F++  F+      D+  LV                  +L +  
Sbjct: 43  FEVRRIAVGPIITRFGNFMIYEFKINDRWKDYEVLVNAKAFDKDFMPLFERGRELLIKTD 102

Query: 52  SECLTGDALFSLRCDCGFQLEAALTQIAEEGRGILLYH-RQEGRNIGLLNKIRAYALQDQ 110
           S C TG+      C C  QL +A+  I + G G+++    QEGR  G   K     LQ +
Sbjct: 103 SGCRTGEIYLDRTCTCRQQLHSAMETIGKRGNGLIITIPNQEGRGHGYAKKYATLVLQKE 162

Query: 111 -GYDTVEANHQLGFAADERDFTLCADMFKLLGV---NEVRLLTNNPKKVEILTEAGINIV 166
            GYDT EA+  +    D RD+     + K  G+   + + ++ NN  K++ + E G +  
Sbjct: 163 LGYDTYEASKAVNKKVDVRDYYGAVAILKFFGIGQSHRLEVIANNNSKLKEVLENGYS-- 220

Query: 167 ERVPLI-VGRNPNNEHYLDTKAEKMG 191
            R+    +  +     +L  K +K+G
Sbjct: 221 ARLAKQDIRADRYTIKHLMAKRDKLG 246


>UniRef50_A6DFW1 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
           n=1 Tax=Lentisphaera araneosa HTCC2155
           RepID=A6DFW1_9BACT
          Length = 360

 Score =  143 bits (362), Expect = 2e-33,   Method: Composition-based stats.
 Identities = 46/176 (26%), Positives = 82/176 (46%), Gaps = 15/176 (8%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALV----YGDISGHTPVLARVHSECLTGD 58
           ++ +    +PT +GDF +  +  +      + LV             VL RVHSE   G+
Sbjct: 189 VEALNIVNMPTDYGDFRLHVYNVIYDPARGIDLVLTCGKDKFDEDETVLVRVHSEWSIGN 248

Query: 59  ALFSLRCDCGFQLEAALTQIAEEGRGILLYHRQ---EGRNIGLLNKIRAYALQDQGYDTV 115
            +  L+ + G  L  A+ Q+A+EG GI+++ R    +  N GL +  +      +  D  
Sbjct: 249 IVNRLKNEEGSSLNRAMKQVADEGSGIIVFLRNTPEQAANSGLFSDSK------RPTDIW 302

Query: 116 EANHQLG--FAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERV 169
             N ++      D   + L A + + LGV ++RL++N+P     +   G+ IVE+V
Sbjct: 303 MENGEIKTLRPKDGMAYGLGAQILRDLGVRKMRLMSNSPSSFIGINNYGLEIVEQV 358


>UniRef50_C5FIC6 GTP cyclohydrolase-2 n=1 Tax=Microsporum canis CBS 113480
           RepID=C5FIC6_NANOT
          Length = 519

 Score =  141 bits (356), Expect = 1e-32,   Method: Composition-based stats.
 Identities = 41/157 (26%), Positives = 70/157 (44%), Gaps = 11/157 (7%)

Query: 34  ALVYGDISGHTPV----LARVHSECLTGDALFSLRCDCGFQL----EAALTQIAEEGRGI 85
             ++GD +           R+H EC   D   S  C C   L    E A+ +  + G G+
Sbjct: 319 VYIFGDPAKMADPNAKLALRIHDECNGSDVFGSDICTCRPYLIFGVEEAVKEAQKGGSGV 378

Query: 86  LLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNEV 145
           ++Y R+EGR +G + K   Y    +  +  +    +    D R   L  D+   LG+ ++
Sbjct: 379 VIYFRKEGRALGEVTKYLVYNA--RASEYFKRTENIAGVKDMRFQALMPDILHWLGITKI 436

Query: 146 -RLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181
            R+L+ +  K + + E GI I+ERVP+     P +  
Sbjct: 437 DRMLSMSNMKHDAIVEQGIPILERVPIPDELIPEDSR 473


>UniRef50_A0M3F6 Riboflavin biosynthesis protein n=17 Tax=Bacteroidetes
           RepID=A0M3F6_GRAFK
          Length = 382

 Score =  141 bits (355), Expect = 2e-32,   Method: Composition-based stats.
 Identities = 40/169 (23%), Positives = 77/169 (45%), Gaps = 5/169 (2%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           +K+  + +L T +G F +  +E+      HVAL  G       ++ RV+S  +  D L +
Sbjct: 217 IKKKEDFELDTRFGKFRLRAYEQTTNSQVHVALTKGAWKPSEEIMVRVNSTLVNNDILGT 276

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
           L  +   +L+     I +EGRG +++     ++  LLN++       +  +         
Sbjct: 277 LTNNADKKLDGMFKAINDEGRGAIVFINPANQSPNLLNRLTELKESQKNGEI----KAPP 332

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPK-KVEILTEAGINIVERVP 170
              D +DF + A +   L ++++RLL+N  + K   +   G+ I E V 
Sbjct: 333 VKMDNKDFGIGAQILHDLEIHKIRLLSNTQQSKRVGMIGYGLEITEYVS 381


>UniRef50_A7IMW5 3,4-dihydroxy-2-butanone 4-phosphate synthase n=93
           Tax=Alphaproteobacteria RepID=A7IMW5_XANP2
          Length = 437

 Score =  139 bits (350), Expect = 7e-32,   Method: Composition-based stats.
 Identities = 45/169 (26%), Positives = 72/169 (42%), Gaps = 14/169 (8%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           + R AE  +PT  G+     +       +H+ALV G I     VL R+H      DA   
Sbjct: 281 VTRAAEFPVPTCVGELQGFSYVTPFDPVNHLALVKGRIGDGEKVLVRLHRADPIADAFGG 340

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
                G  ++ AL +I  EGRG+L+Y R     +              G+   +++ ++ 
Sbjct: 341 -----GKTIQRALERIEAEGRGVLVYLRDGTAGV---------PAVAMGHGGEKSSSEIE 386

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPL 171
                R+  L A + + LG+  +RLL +  +    L   GI IV+  PL
Sbjct: 387 RDRHWREVGLGAQILRDLGIVSIRLLASKSRTYVGLAGFGIEIVDTEPL 435


>UniRef50_C6X067 3,4-dihydroxy-2-butanone 4-phosphate synthase / GTP cyclohydrolase
           II n=1 Tax=Flavobacteriaceae bacterium 3519-10
           RepID=C6X067_FLAB3
          Length = 416

 Score =  138 bits (347), Expect = 1e-31,   Method: Composition-based stats.
 Identities = 44/169 (26%), Positives = 74/169 (43%), Gaps = 5/169 (2%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           ++R+ E K+ T +GDF    F+E +T   H AL  G      PVL RV +     D L  
Sbjct: 253 IERIEERKVKTHYGDFDFFAFKETSTDQIHFALTKGTWVVDEPVLVRVQASNAYFDVLSR 312

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
           L       LE     I EEG+G L++          L K++ +     G +      +  
Sbjct: 313 LTAGEKPLLEKVTNMINEEGKGALIFINNVSTAENTLRKLQQFIDFQDGQE-----KRPT 367

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPL 171
            A++  D+ +   + K LG+ + R++T N  +  ++    + + E V L
Sbjct: 368 LASNFHDYGIGTQILKNLGITKFRVITQNVNQKPLVGGYDVEVTEMVQL 416


>UniRef50_Q9R6K1 GTP cyclohydrolase-2 n=1 Tax=Agrobacterium tumefaciens
           RepID=Q9R6K1_RHIRD
          Length = 190

 Score =  137 bits (346), Expect = 2e-31,   Method: Composition-based stats.
 Identities = 48/172 (27%), Positives = 79/172 (45%), Gaps = 7/172 (4%)

Query: 4   KRVAEAKLPTPWGDFLMVGFEELATGH--DHVALVYGDISGHTPVLARVHSECLTGDALF 61
           + V + ++    G F        A     DH+A      S   P+  R+ S C+ G    
Sbjct: 22  EVVRDVEIENSIGTFSAACIRVKANNETTDHLAFYK---SIGVPLTLRIQSGCVLGHVFG 78

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYH-RQEGRNIGLLNKIRAYAL-QDQGYDTVEANH 119
              CDC  QL+ +L  I  +  G+++Y    + R  G+ +K++ Y   Q++  D+  A  
Sbjct: 79  DNECDCKAQLDKSLRYIHSQNEGMVIYTPSHDARGRGIYSKLQIYRTRQERCIDSAAACR 138

Query: 120 QLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPL 171
           + G   D RDF+  + +  +  V  V LL  +  K + L EAGI++V  VPL
Sbjct: 139 ETGVPFDTRDFSQFSSILGVFDVKSVALLGRSAAKAKALIEAGISVVSSVPL 190


>UniRef50_Q882G0 3,4-dihydroxy-2-butanone 4-phosphate synthase n=38
           Tax=Proteobacteria RepID=RIBB_PSESM
          Length = 369

 Score =  136 bits (344), Expect = 3e-31,   Method: Composition-based stats.
 Identities = 45/172 (26%), Positives = 76/172 (44%), Gaps = 9/172 (5%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           + R+ E +LPT  G F +  +E+   G  H+A+V GDI    P L RVH      D + +
Sbjct: 206 IVRIGERELPTVHGTFRLFSYEDRIEGGVHMAMVMGDIRREDPTLVRVHVVDPLRDLVGA 265

Query: 63  -LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
                  + L AAL ++AEEG G+++       +  LL +I       + Y   ++    
Sbjct: 266 EYTGPANWTLWAALQRVAEEGCGVVVVLANHESSQALLERIPQLTQPPRQYTRSQSRI-- 323

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIV 173
                  +    A + + LG+ ++R L   P K   LT   + ++E +P   
Sbjct: 324 -----YSEVGTGAQILQDLGIGKLRHLG-PPLKYAGLTGYDLEVIESIPFPG 369


>UniRef50_Q2NZ90 3,4-dihydroxy-2-butanone 4-phosphate synthase n=11
           Tax=Gammaproteobacteria RepID=Q2NZ90_XANOM
          Length = 379

 Score =  134 bits (339), Expect = 1e-30,   Method: Composition-based stats.
 Identities = 47/173 (27%), Positives = 74/173 (42%), Gaps = 10/173 (5%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           ++RV E  + T +G F +V + +      H ALV G    HTP L RV  E    D L  
Sbjct: 206 VERVDERDITTEFGPFKLVTYRDRIAHDLHFALVRGSADPHTPTLVRVQVENPLADLLHW 265

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
            R D G     AL  IA EG+G+++       +  LL ++R            EA     
Sbjct: 266 QRDDFGVAATDALRAIAAEGQGVMVVLSAPRDSESLLARLRQQP---------EAAANAK 316

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGR 175
             +  R     A +   LG+ ++R+L  + ++V  +   G+ +VE +    G 
Sbjct: 317 DVSQWRRHGAGAQILAELGLGKLRVLGTSRRQV-GVAGFGLEVVEYLECHAGE 368


>UniRef50_D1ZD95 GTP cyclohydrolase-2 n=1 Tax=Sordaria macrospora RepID=D1ZD95_SORMA
          Length = 528

 Score =  132 bits (332), Expect = 8e-30,   Method: Composition-based stats.
 Identities = 48/198 (24%), Positives = 74/198 (37%), Gaps = 38/198 (19%)

Query: 11  LPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQ 70
           LP P G   +  F + A                  +  R+H EC   D   S  C C   
Sbjct: 306 LP-PIGGLTVYCFGDPANMS----------DPSKKLALRIHDECNGSDVFCSDICTCRPY 354

Query: 71  L----EAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQ------------------ 108
           L    E A+ +  + G G+++Y R+EGR +G + K R   LQ                  
Sbjct: 355 LIFGIEEAVKEAQKGGSGVVIYFRKEGRALGEVTKYRMSNLQTMLTFSCVEEFLIVYNAR 414

Query: 109 ----DQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNEV-RLLTNNPKKVEILTEAGI 163
               D   D  +    +    D R   L  D+   LG+ ++ R+L+ +  K + +   GI
Sbjct: 415 KRGADLASDYFKRTENIAGVKDMRFQALMPDILHWLGITKIDRMLSMSNMKHDAIVGQGI 474

Query: 164 NIVERVPLIVGRNPNNEH 181
            I+ERV L     P +  
Sbjct: 475 PIIERVELPESWIPADSR 492


>UniRef50_Q1DG18 GTP cyclohydrolase-2 n=2 Tax=Bacteria RepID=Q1DG18_MYXXD
          Length = 454

 Score =  131 bits (331), Expect = 9e-30,   Method: Composition-based stats.
 Identities = 49/189 (25%), Positives = 79/189 (41%), Gaps = 23/189 (12%)

Query: 11  LPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQ 70
           LP P G   +  F     G + +A          P+  RVH EC   D   S  C C   
Sbjct: 251 LP-PIGGLTLYVF----GGIETLA------DRDVPLTVRVHDECNGSDVFGSDICTCRPY 299

Query: 71  L----EAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYAL--QDQGYDT----VEANHQ 120
           L    E  +      G G+++Y R+EGR +G + K   Y    + +G D+     +    
Sbjct: 300 LAHGIEECVRTAQAGGAGLIVYLRKEGRALGEVTKFLVYNARKRQEGGDSAATYFQRTEC 359

Query: 121 LGFAADERDFTLCADMFKLLGVNEV-RLLTNNPKKVEILTEAGINIVERVPLIVGRNPNN 179
           +    D R   L  D+   LG+  + R ++ +  K + +T +GI I+ERVP+     P +
Sbjct: 360 VAGVQDMRFQELMPDVLHWLGITRIHRFVSMSDMKHDAITRSGIEILERVPIPDELIPAD 419

Query: 180 EHY-LDTKA 187
               ++ K 
Sbjct: 420 AKVEMEAKK 428


>UniRef50_B7FNY5 Predicted protein n=1 Tax=Phaeodactylum tricornutum CCAP 1055/1
           RepID=B7FNY5_PHATR
          Length = 494

 Score =  130 bits (328), Expect = 2e-29,   Method: Composition-based stats.
 Identities = 47/182 (25%), Positives = 73/182 (40%), Gaps = 22/182 (12%)

Query: 11  LPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQ 70
           LP P G   +  + + AT                 +  RVH EC   D   S  C C   
Sbjct: 283 LP-PIGGLTIYIWGDPATI----------PDEDIELTCRVHDECNGSDVFGSDICTCRPY 331

Query: 71  L----EAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYAL--QDQGYDTVE----ANHQ 120
           L    E  +    + G GI++Y+R+EGR++G + K   Y    + +G D+ E       Q
Sbjct: 332 LTHAIEECIRTAQKGGCGIVIYYRKEGRSLGEVTKYLVYNTRKRQEGGDSAERYFSCTEQ 391

Query: 121 LGFAADERDFTLCADMFKLLGVNEV-RLLTNNPKKVEILTEAGINIVERVPLIVGRNPNN 179
           +    D R   L  D    LGV ++   ++ +  K + +   GI IV RV +     P +
Sbjct: 392 VAGVQDTRFQALMPDPLHFLGVTKIDNFISMSDMKYDAIVSTGIKIVNRVEIPPEMVPED 451

Query: 180 EH 181
             
Sbjct: 452 AK 453


>UniRef50_Q9US41 Uracil-regulated protein 1 n=101 Tax=cellular organisms
           RepID=URG1_SCHPO
          Length = 439

 Score =  129 bits (325), Expect = 5e-29,   Method: Composition-based stats.
 Identities = 40/160 (25%), Positives = 67/160 (41%), Gaps = 13/160 (8%)

Query: 34  ALVYGDI----SGHTPVLARVHSECLTGDALFSLRCDCGFQL----EAALTQIAEEGRGI 85
           A ++G           +  RVH EC   D   S  C C   L    E A  +    G G+
Sbjct: 249 AYIFGPPEYLSDTSKSLAVRVHDECNGSDVFQSDICTCRPYLTFGIEEAAKEAQNGGAGL 308

Query: 86  LLYHRQEGRNIGLLNKIRAYALQDQGYDTVE----ANHQLGFAADERDFTLCADMFKLLG 141
           ++Y R+EGR +G + K   Y  + +  D+ E       +L    D R   L  D+    G
Sbjct: 309 VVYFRKEGRALGEVVKYLVYNKRKRTGDSAENYFKRTEELAGVRDMRFQALMPDILHWFG 368

Query: 142 VNEV-RLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNE 180
           + ++ R+L+ +  K + +   GI I+ R+ +     P + 
Sbjct: 369 IKKIDRMLSMSNMKHDAIVGQGIKILNRITIPDDLIPEDS 408


>UniRef50_Q1QUC7 GTP cyclohydrolase II n=69 Tax=cellular organisms
           RepID=Q1QUC7_CHRSD
          Length = 386

 Score =  129 bits (325), Expect = 6e-29,   Method: Composition-based stats.
 Identities = 39/177 (22%), Positives = 73/177 (41%), Gaps = 6/177 (3%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           +  V  + + T +G+  +  F +      H+ALV G     +P   RVH      D L  
Sbjct: 212 VDEVERSVVDTAFGELTLHVFRDRIQNTHHLALVKGTPRTESPTTVRVHIADTLRDLLML 271

Query: 63  LRCD-CGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
            R D   +   +AL QIA+   G+ +        + L +++     +     + E++   
Sbjct: 272 TRPDSHSWTAASALAQIADAEAGVFVLLDDGRPRLDLKDQLDVLLGRKPAPRSSESD--- 328

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGRNPN 178
             A +       + + + LGV ++RLL+ +P K   L+   + +VERV      +  
Sbjct: 329 -GAGNYLTIGTGSQILRQLGVGQMRLLS-SPWKFSALSGFDLEVVERVGGDTPESDQ 383


>UniRef50_B4RM34 3,4-dihydroxy-2-butanone 4-phosphate synthase n=47
           Tax=Proteobacteria RepID=B4RM34_NEIG2
          Length = 445

 Score =  129 bits (324), Expect = 7e-29,   Method: Composition-based stats.
 Identities = 38/165 (23%), Positives = 67/165 (40%), Gaps = 14/165 (8%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           L+ + +A + TPWG+F    + +  +G  H+ALV G  S  T  L RVH      D    
Sbjct: 289 LEDMGDAPVQTPWGEFQQHVYVDKLSGETHLALVKGTPSADTETLVRVHEPFSVMD-FIQ 347

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
                 + L  AL ++ +   G+++          LL++            T+       
Sbjct: 348 ANPRHSWSLPKALERVQQAESGVVILLHHTEDGASLLDR------------TLPKGANQA 395

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVE 167
           +  D + + + A +   L V ++R+L   P     LT  G+ +V 
Sbjct: 396 YKWDSKSYGIGAQILAGLHVKKLRVLGQ-PSSFTGLTGFGLEVVG 439


>UniRef50_Q5K843 GTP cyclohydrolase-2 n=5 Tax=Eukaryota RepID=Q5K843_CRYNE
          Length = 562

 Score =  129 bits (324), Expect = 7e-29,   Method: Composition-based stats.
 Identities = 37/161 (22%), Positives = 63/161 (39%), Gaps = 13/161 (8%)

Query: 34  ALVYGDI----SGHTPVLARVHSECLTGDALFSLRCDCGFQL----EAALTQIAEEGRGI 85
             + GD        T V  R H  C   D   S  C C   L      A+      G G+
Sbjct: 367 VYIMGDPAKLQDPDTEVTCRPHDSCSGSDVFGSDICTCRPYLIFGISEAIKCAQRGGVGV 426

Query: 86  LLYHRQEGRNIGLLNKIRAYALQDQGYDTVEA----NHQLGFAADERDFTLCADMFKLLG 141
           ++Y ++EGR +G + K   Y  + +G DT         ++    D R   L  D+   LG
Sbjct: 427 IVYFQKEGRALGEVVKYMVYNRRKRGGDTAAEYFNNTERVAGVKDARHQALMPDVLHFLG 486

Query: 142 VNEV-RLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181
           +  +  L++ +  K + +  +GI + +R  +     P +  
Sbjct: 487 IKHIHNLISMSNMKYDAIIGSGITVGKRYEIPEELIPADGR 527


>UniRef50_D2UG04 Putative gtp cyclohydrolase II 3, 4-dihydroxy-2-butanone
           4-phosphate synthase, riboflavin biosynthesis protein
           n=1 Tax=Xanthomonas albilineans RepID=D2UG04_XANAL
          Length = 385

 Score =  127 bits (319), Expect = 2e-28,   Method: Composition-based stats.
 Identities = 43/161 (26%), Positives = 67/161 (41%), Gaps = 11/161 (6%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           ++R+ E  + T +GDF +V + +      H ALV G +   TP L RV  E    D L  
Sbjct: 214 VERIDERPIVTEFGDFTLVTYRDRIAHDLHFALVRGPLDADTPTLVRVQVENPLADLLHW 273

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
            R D G     AL  IA   RG+++       +  LL ++RA      G D         
Sbjct: 274 RREDFGVAASDALRAIATADRGVMVVLSAPRDSQALLARLRAQPEAAHGKD--------- 324

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGI 163
                R     + +   LG+ ++R+L   P++   L   G+
Sbjct: 325 -VGQWRRNGAGSQILADLGLGKLRVLG-TPRRQIGLAGFGL 363


>UniRef50_D0NXG3 Putative uncharacterized protein n=1 Tax=Phytophthora infestans
           T30-4 RepID=D0NXG3_PHYIN
          Length = 459

 Score =  126 bits (316), Expect = 5e-28,   Method: Composition-based stats.
 Identities = 42/151 (27%), Positives = 67/151 (44%), Gaps = 11/151 (7%)

Query: 41  SGHTPVLARVHSECLTGDALFSLRCDCGFQL----EAALTQIAEEGRGILLYHRQEGRNI 96
                +  RVH EC   D   S  C C   L    E  +    E G GI++Y R+EGR +
Sbjct: 269 DPTKKLAVRVHDECNGSDVFGSDICTCRPYLAHGIEVCVQTAQEGGAGIIVYFRKEGRAL 328

Query: 97  GLLNKIRAYAL--QDQGYDTVE----ANHQLGFAADERDFTLCADMFKLLGVNEV-RLLT 149
           G + K   Y L  + +G D+ E        +    D R   L  D    LG+ ++ + ++
Sbjct: 329 GEVTKYLVYNLRKRQEGGDSAEEYFNCTQTVAGIQDVRFQALMPDALHWLGITKIDKFVS 388

Query: 150 NNPKKVEILTEAGINIVERVPLIVGRNPNNE 180
            +  K + + ++GI IVER+P+     P + 
Sbjct: 389 MSDMKYDAIVKSGIEIVERIPIPEELVPKDA 419


>UniRef50_Q1AZ21 GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate
           synthase n=2 Tax=Bacteria RepID=Q1AZ21_RUBXD
          Length = 366

 Score =  125 bits (314), Expect = 1e-27,   Method: Composition-based stats.
 Identities = 46/147 (31%), Positives = 70/147 (47%), Gaps = 19/147 (12%)

Query: 2   QLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALF 61
            ++ + E  LPT +G+F +  +  ++TG  H AL+ G+   + P L  V + C TGDAL 
Sbjct: 205 HVRCLGEEALPTRFGEFRLRSYAGVSTGLIHRALLAGEPGENGPPLVGVRAACPTGDALH 264

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
           SLRCDCG +L  A+ ++A EG G++LY    G    L                       
Sbjct: 265 SLRCDCGERLRDAMERVAAEGEGVILYL-HPGPGAPLH------------------PLPG 305

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLL 148
           G   D   +    ++ + LG+  VRLL
Sbjct: 306 GEDEDLAPYRAGVEILRDLGLGRVRLL 332


>UniRef50_A6G9U6 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II
           n=1 Tax=Plesiocystis pacifica SIR-1 RepID=A6G9U6_9DELT
          Length = 383

 Score =  123 bits (309), Expect = 4e-27,   Method: Composition-based stats.
 Identities = 53/179 (29%), Positives = 79/179 (44%), Gaps = 12/179 (6%)

Query: 3   LKRVAEAKL------PTPWGDFLMVGFEELATGH-DHVALVYGDISGHTPVLARVHSECL 55
           ++ +A A         T    + +  F  L       +AL  GD+SG  PVL R     L
Sbjct: 210 IEEIARAPFVSPVLGITADDGWTIRSFRSLVEPVGRFIALTKGDLSGDDPVLLRAQRAQL 269

Query: 56  TGDALFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTV 115
            GD       D   +L A+L +I EEGRG  LY        G   +   +   ++G +  
Sbjct: 270 VGDVFG-FGDDSATRLRASLARIDEEGRGAFLYVLG---GSGYDVEAELHLAGERG-ELP 324

Query: 116 EANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVG 174
           EA       +  RDF L A + K +GV+++R+LTNNP+K+  L   GI +V    +   
Sbjct: 325 EAPGLRPRESGFRDFGLGAQVLKHMGVSKIRVLTNNPRKIVGLEGFGIEVVGSAGIQAP 383


>UniRef50_A4A6E4 Riboflavin biosynthesis protein ribA n=5 Tax=unclassified
           Gammaproteobacteria RepID=A4A6E4_9GAMM
          Length = 380

 Score =  122 bits (308), Expect = 4e-27,   Method: Composition-based stats.
 Identities = 41/174 (23%), Positives = 82/174 (47%), Gaps = 9/174 (5%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           ++RV E  + T +G+F +  + +   G  H+AL  G+IS   P L RVH+     D L S
Sbjct: 212 IERVREGVISTRYGNFQLATYRDRTHGGLHIALSLGEISATEPTLVRVHATSTLRDLLGS 271

Query: 63  -LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
            ++   G+ ++ +L  IA+ G G+L+   +   +  LL+ +      D     +E     
Sbjct: 272 DVQGQVGWSVQRSLAAIAKSGSGVLVLLGRSETDEQLLHSV------DLALGEIEP-RDP 324

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIVGR 175
             +       + + + + LGV ++RL+   P K   ++  G+ +++ +  +V  
Sbjct: 325 KASDSYNTVGVGSQILRELGVGKIRLMG-APIKYNAISGFGLEVIDYLEPVVSE 377


>UniRef50_Q2G801 GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate
           synthase n=74 Tax=cellular organisms RepID=Q2G801_NOVAD
          Length = 424

 Score =  122 bits (307), Expect = 5e-27,   Method: Composition-based stats.
 Identities = 36/171 (21%), Positives = 68/171 (39%), Gaps = 18/171 (10%)

Query: 3   LKRVAEAKLPTPWG-DFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALF 61
           ++   +A   T +G ++ +  +     G  H+ L  G +    P L R+H+  +  D L 
Sbjct: 269 VECANQAPFHTDYGGEWTIKTYRNKVDGSAHLVLQKGAVVPGKPTLVRMHAISVLSDVLG 328

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
                    L+ A+T I E G G+++                   L ++   T       
Sbjct: 329 QPGPR-KRILQRAMTAIGEAGSGVIVLLMP----------TDPQQLMNEVAGTA------ 371

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLI 172
           G   + R + + A +   LGV+++ LLTN+   +  L   G++IV    + 
Sbjct: 372 GHDMELRSYGIGAQILADLGVHDMVLLTNSHHNLVALEGYGLSIVGEQAIP 422


>UniRef50_Q1GEQ5 GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate
           synthase n=12 Tax=Alphaproteobacteria RepID=Q1GEQ5_SILST
          Length = 374

 Score =  121 bits (304), Expect = 1e-26,   Method: Composition-based stats.
 Identities = 50/171 (29%), Positives = 78/171 (45%), Gaps = 23/171 (13%)

Query: 3   LKRVAEAKLPTPWG-DFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALF 61
           +   A + + + +G D+ M  F +     +HV L+ GDI+   PVL R H+     D L 
Sbjct: 220 VDETARSTVTSEYGGDWEMRIFTDQTHDVEHVVLIKGDITTPEPVLTRTHALHEASDLLG 279

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
            L      +L  A+  IA+EGRGI+   RQ    +        YA  ++G  T++     
Sbjct: 280 -LGPKPAGELPRAMELIADEGRGIVCLFRQPRNAL--------YASDEEGVRTIKQT--- 327

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPK-KVEILTEAGINIVERVPL 171
                     L A +   LGV E+ LLT++P+ K   L   G++IV   P+
Sbjct: 328 ---------GLGAQILNKLGVEELILLTDSPQTKYVGLDAYGLSIVGTRPI 369


>UniRef50_A8PF74 GTP cyclohydrolase-2 n=1 Tax=Coprinopsis cinerea okayama7#130
           RepID=A8PF74_COPC7
          Length = 513

 Score =  118 bits (297), Expect = 9e-26,   Method: Composition-based stats.
 Identities = 34/137 (24%), Positives = 61/137 (44%), Gaps = 9/137 (6%)

Query: 54  CLTGDALFSLRCDCGFQL----EAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQD 109
           C   D   S  C C   L    E  +    + G G++ Y R+EGR +G + K   Y L+ 
Sbjct: 341 CNGSDVFGSDICTCKPYLVYAIEECIRGAQKGGVGVVAYFRKEGRALGEVTKYLVYNLRK 400

Query: 110 QGYDTVE----ANHQLGFAADERDFTLCADMFKLLGVNEV-RLLTNNPKKVEILTEAGIN 164
           +G D+ +    +   +    D R   L  D+   LG+ +V R+++ +  K + + ++GI 
Sbjct: 401 RGGDSADKYFKSTEMIAGVKDMRFQALMPDVLHWLGIRKVDRMVSMSDMKYDAIVKSGIP 460

Query: 165 IVERVPLIVGRNPNNEH 181
           I+ R  +     P +  
Sbjct: 461 ILTRYDIPDHLIPPDSR 477


>UniRef50_B2AIS6 RIBOFLAVIN BIOSYNTHESIS BIFUNCTIONAL PROTEIN : GTP CYCLOHYDROLASE
           II AND 3, 4-DIHYDROXY-2-BUTANONE-4-PHOSPHATE SYNTHASE
           (DHBP SYNTHASE) n=3 Tax=Cupriavidus RepID=B2AIS6_CUPTR
          Length = 366

 Score =  117 bits (293), Expect = 2e-25,   Method: Composition-based stats.
 Identities = 43/169 (25%), Positives = 75/169 (44%), Gaps = 13/169 (7%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALF- 61
           L+R   ++L TP+G F +  + +      H+ALV G    HTPVL RV +  +  D L  
Sbjct: 208 LRRTRSSELATPFGRFTVHAYHDAPVDALHLALVLGRPDPHTPVLTRVQAVEMQRDVLAF 267

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
                  + LE +L +I  EG G+L+   +       L+++ A A         +     
Sbjct: 268 GTPAQPAWNLERSLERIGAEGCGVLVLLDERESPQQRLDRLAAPAAAAPAPAFAQ----- 322

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVP 170
                 R   + A + + +G +++RLL+ +P     +T   + + E VP
Sbjct: 323 ------RALGVGAQILRDVGAHKLRLLS-HPVPYRAVTGFDLEVTEFVP 364


>UniRef50_A4JQ12 GTP cyclohydrolase II n=9 Tax=Proteobacteria RepID=A4JQ12_BURVG
          Length = 382

 Score =  117 bits (293), Expect = 3e-25,   Method: Composition-based stats.
 Identities = 42/179 (23%), Positives = 73/179 (40%), Gaps = 27/179 (15%)

Query: 2   QLKRVAEAKLPTPWGDF--------LMVGFEELATGHDHVALVYGDISGHTPVLARVHSE 53
           + +R+ EA      G F         +V +       +H+A V GD+ G  PVL R+H+ 
Sbjct: 215 RTERLVEA---VEHGSFTEPNGRHWRIVVYRNRIDQVEHIAFVMGDLRGADPVLVRMHAM 271

Query: 54  CLTGDALFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYD 113
               D +          L  A   +  E RG+++  R E R   +  ++RA         
Sbjct: 272 DTMNDVIGGH---HLASLRGAARLLENENRGVIVVIR-ESRLTAVSERVRAMMHPKPA-- 325

Query: 114 TVEANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLI 172
                       + RD+ + A +   LGV  + LL+N+ + +  L   G+N+VE+  + 
Sbjct: 326 ----------EPELRDYGIGAQILTELGVKNMILLSNHERTIVGLEGYGLNMVEQRKIE 374


>UniRef50_A6RZS8 GTP cyclohydrolase-2 n=1 Tax=Botryotinia fuckeliana B05.10
           RepID=A6RZS8_BOTFB
          Length = 470

 Score =  116 bits (290), Expect = 6e-25,   Method: Composition-based stats.
 Identities = 41/161 (25%), Positives = 64/161 (39%), Gaps = 24/161 (14%)

Query: 34  ALVYGDISGHTPVLAR----VHSECLTGDALFSLRCDCGFQL----EAALTQIAEEGRGI 85
              +GD +  +    R    VH EC   D   S  C C   L    E A+ +  + G G+
Sbjct: 264 VYCFGDPAKMSDENVRLALRVHDECNGSDVFGSDICTCRPYLIYGIEEAVKEAQKGGSGV 323

Query: 86  LLYHRQEGRNIGLLNKIRAYALQDQGYD----TVEANHQLGFAADERDFTLCADMFKLLG 141
           + Y R+EGR +G + K   Y  + +G D      +    +    D R   L  D+   LG
Sbjct: 324 I-YFRKEGRALGEVTKYLVYNARKRGLDRASEYFKRTENIAGVKDMRFQALMPDILHWLG 382

Query: 142 VNEV-RLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181
           + ++ R+L+ +           I I ERV L     P +  
Sbjct: 383 IKKIDRMLSMS----------KIPIHERVELPESWIPADSR 413


>UniRef50_Q1AV39 GTP cyclohydrolase-2 n=1 Tax=Rubrobacter xylanophilus DSM 9941
           RepID=Q1AV39_RUBXD
          Length = 152

 Score =  114 bits (286), Expect = 2e-24,   Method: Composition-based stats.
 Identities = 48/147 (32%), Positives = 70/147 (47%), Gaps = 20/147 (13%)

Query: 2   QLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALF 61
           +L+R AEA+LPT +G+F +V + +   G  H+ALV G++ G   V A +H  CL G+A  
Sbjct: 18  RLRREAEARLPTRFGEFRVVAYRDAVDGRAHLALVAGEVRGRGRVFAHIHRSCLLGEAFG 77

Query: 62  SLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
           SL C CG  LE A+ +   EGRG++ Y                            A+   
Sbjct: 78  SLGCGCGALLEGAMQRAQREGRGVIAYV--------------------ARGGGAPASGAG 117

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLL 148
                E    + A +F+ LG+  VRLL
Sbjct: 118 CPKDGEGACAVGAAIFEDLGLRSVRLL 144


>UniRef50_C1HDW1 GTP cyclohydrolase-2 n=2 Tax=Onygenales RepID=C1HDW1_PARBA
          Length = 500

 Score =  111 bits (277), Expect = 2e-23,   Method: Composition-based stats.
 Identities = 36/157 (22%), Positives = 59/157 (37%), Gaps = 46/157 (29%)

Query: 34  ALVYGDISGHTPVLAR----VHSECLTGDALFSLRCDCGFQL----EAALTQIAEEGRGI 85
              +GD +  +    R    VH EC   D   S  C C   L    E A+ +    G G+
Sbjct: 344 VYCFGDPAKMSDPSVRLALRVHDECNGSDVFGSDICTCRPYLIFGIEEAVKEAQRGGSGV 403

Query: 86  LLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNEV 145
           ++Y R+EGR +G                                     ++   LG+ ++
Sbjct: 404 VIYFRKEGRALG-------------------------------------EILHWLGITKI 426

Query: 146 -RLLTNNPKKVEILTEAGINIVERVPLIVGRNPNNEH 181
            R+L+ +  K + + E GI I+ERVP+     P +  
Sbjct: 427 DRMLSMSNMKHDAIVEQGIPILERVPIPDELIPEDSR 463


>UniRef50_Q0G5B3 GTP CYCLOHYDROLASE II / 3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE
           SYNTHASE n=1 Tax=Fulvimarina pelagi HTCC2506
           RepID=Q0G5B3_9RHIZ
          Length = 375

 Score =  110 bits (276), Expect = 3e-23,   Method: Composition-based stats.
 Identities = 35/170 (20%), Positives = 64/170 (37%), Gaps = 12/170 (7%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           +K V E  +        +  +E       HV  V+GD+     V  R+H E    D    
Sbjct: 211 VKAVREETMTIGGLTGQIRIYETPFDDLQHVVAVFGDVREGEGVPVRIHREQPVTDLFGR 270

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANH--- 119
            R D    +E A+ +I + G G+L+  R          ++  + L D   D  +      
Sbjct: 271 TR-DTKTWVEIAVDEIGKLGHGVLMLLRTP--------EVDEFDLGDTVIDHADGEKHQS 321

Query: 120 QLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERV 169
            +      R+  L A + + L +  +R + ++ +    LT  GI +   +
Sbjct: 322 AISRRKRWREVGLGAQILRDLQIRSIREIASHERAYVGLTGFGIEVTGTI 371


>UniRef50_D0LW49 3,4-dihydroxy-2-butanone 4-phosphate synthase n=2 Tax=cellular
           organisms RepID=D0LW49_HALO1
          Length = 408

 Score =  109 bits (274), Expect = 4e-23,   Method: Composition-based stats.
 Identities = 46/162 (28%), Positives = 75/162 (46%), Gaps = 15/162 (9%)

Query: 17  DFLMVGFEELATGHDHVALVYGDISGHTPV----LARVHSECLTGDALFSLRCDCGFQLE 72
            F    +       +++ALV GD++         L RV S    GD           +L 
Sbjct: 226 PFQCAIYGAQVEDTEYMALVRGDVAAAGAADEAVLVRVQSVSPVGDTFGV-----KPELA 280

Query: 73  AALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG-FAADERDFT 131
           AAL  I + G G+ LY   + R+  L +  R +AL++     +E     G  +   RDF 
Sbjct: 281 AALRTIDDAGVGVCLYVYNKARS-SLEHDFRKHALREA----IEPPAGGGAHSETLRDFG 335

Query: 132 LCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERVPLIV 173
           L A +   LG ++VRLL+N+ +++  +   GI +VERV + +
Sbjct: 336 LGAQVLADLGCHKVRLLSNSSRRIAGIEGFGIEVVERVAIDI 377


>UniRef50_A0PS46 Riboflavin biosynthesis protein RibA1 n=16 Tax=Corynebacterineae
           RepID=A0PS46_MYCUA
          Length = 365

 Score =  104 bits (260), Expect = 2e-21,   Method: Composition-based stats.
 Identities = 46/151 (30%), Positives = 70/151 (46%), Gaps = 24/151 (15%)

Query: 2   QLKRVAEAKLPTPWGDFLMVGFEEL---ATGHDHVALVYGDISGHTPVLARVHSECLTGD 58
           Q+ R+ E  LPT  G+  ++GF +L     G +H+A+V G      PV   VH ECLTGD
Sbjct: 201 QVIRLTETTLPTWAGNSRVIGFRDLGPANPGGEHLAVVIGAPDSGVPVALHVHIECLTGD 260

Query: 59  ALFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEG--RNIGLLNKIRAYALQDQGYDTVE 116
              S  C CG +L  AL+ ++ +G G++LY +  G  R  GL       + ++   D + 
Sbjct: 261 VFGSTGCRCGGELNGALSAMSAQGSGVVLYLQPPGPPRACGLFA-----SDEETPADFMS 315

Query: 117 ANHQLGFAADERDFTLCADMFKLLGVNEVRL 147
                              M + LGV  ++L
Sbjct: 316 ETVTW--------------MLRDLGVYAIKL 332


>UniRef50_Q1UZ97 GTP cyclohydrolase II /3,4-dihydroxy-2-butanone 4-phosphatesynthase
           n=4 Tax=SAR11 cluster RepID=Q1UZ97_PELUB
          Length = 366

 Score =  101 bits (253), Expect = 1e-20,   Method: Composition-based stats.
 Identities = 29/162 (17%), Positives = 63/162 (38%), Gaps = 11/162 (6%)

Query: 8   EAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFSLRCDC 67
           ++ +      + +  +E L  G +H AL+ G+I        RV S  +  + L + +   
Sbjct: 214 QSDIKVKNQKYKIRIYENLLDGSEHFALIKGNIKKGIIPRVRVISSNVVQNYLINQQLP- 272

Query: 68  GFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADE 127
               +  L    +    +L++     ++  L +  +            + N +L      
Sbjct: 273 -NSFDKTLNYFKKFNNCVLVFI----KDTNLKSVTQTLKDYKNKNFYKKGNDKL-----I 322

Query: 128 RDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVERV 169
           R++ + A + K L +  + L+T + KKV  L    I I ++ 
Sbjct: 323 RNYGIGAQIIKDLKIKNMILITKSLKKVIGLEGYDIKITKQE 364


>UniRef50_C0XBJ0 GTP cyclohydrolase-2 n=3 Tax=Lactobacillus gasseri
           RepID=C0XBJ0_9LACO
          Length = 96

 Score = 97.2 bits (241), Expect = 2e-19,   Method: Composition-based stats.
 Identities = 32/88 (36%), Positives = 45/88 (51%), Gaps = 5/88 (5%)

Query: 113 DTVEANHQLGFAADERDFT-----LCADMFKLLGVNEVRLLTNNPKKVEILTEAGINIVE 167
           D    N  L  A   R  T     + A + K L + E+ LLTNNP K++ L + GI I +
Sbjct: 4   DQYYMNLALQEAKKGRFQTWKNPLVGAVIVKELKIKEINLLTNNPDKIDQLNDYGIKINK 63

Query: 168 RVPLIVGRNPNNEHYLDTKAEKMGHLLN 195
           R+PL +  N  +  YL TK ++  HLL 
Sbjct: 64  RIPLEIAPNDVDRFYLQTKKKRFHHLLE 91


>UniRef50_UPI0001850D2C bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP
           cyclohydrolase II protein n=1 Tax=Bacillus coahuilensis
           m4-4 RepID=UPI0001850D2C
          Length = 187

 Score = 96.8 bits (240), Expect = 3e-19,   Method: Composition-based stats.
 Identities = 30/155 (19%), Positives = 67/155 (43%), Gaps = 24/155 (15%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           +++ +E +L      F ++ ++++ TG +H+AL+ G  S       RVH+E L  +    
Sbjct: 57  IEKTSEQRLVIQGDTFELITYQDIFTGLEHLALIKGKPS-DETTYVRVHAESLIKELTGD 115

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
                   ++  + Q+  +  G+ LY R            +    Q        +  +LG
Sbjct: 116 ------SSVKQGIEQMKNKEHGVFLYIR----------STKTIHEQI-------SEEELG 152

Query: 123 FAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEI 157
                +D+ + A + + +G+ ++  +T++PKK   
Sbjct: 153 EDESLKDYGIGAQILQDIGIKKMIWITDHPKKYPA 187


>UniRef50_UPI0001BCED67 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP
           cyclohydrolase II protein n=1 Tax=Campylobacter fetus
           subsp. venerealis str. Azul-94 RepID=UPI0001BCED67
          Length = 169

 Score = 89.1 bits (220), Expect = 7e-17,   Method: Composition-based stats.
 Identities = 30/91 (32%), Positives = 44/91 (48%), Gaps = 1/91 (1%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           ++R  E   PT +G+F  + + E+ T  +HVALV GDIS     L RV +  + GD   +
Sbjct: 69  IEREIEKPFPTNYGEFRAIIYREVLTEQEHVALVKGDISSGAA-LVRVQAGNVFGDIFNA 127

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEG 93
              D    +  A+ QI    +   LY R E 
Sbjct: 128 SGLDGAKIIAGAMQQIERAEKEFFLYMRHEE 158


>UniRef50_Q59AD7 GTP cyclohydrolase-2 (Fragment) n=2 Tax=Buchnera aphidicola
          RepID=Q59AD7_9ENTR
          Length = 81

 Score = 88.7 bits (219), Expect = 1e-16,   Method: Composition-based stats.
 Identities = 43/81 (53%), Positives = 63/81 (77%), Gaps = 6/81 (7%)

Query: 16 GDFLMVGFEELA--TGHDHVALVYGDIS----GHTPVLARVHSECLTGDALFSLRCDCGF 69
          G+F ++GFEE++     +HVAL+YG+I+     +  VL R+HSECLTGDALFSLRCDCGF
Sbjct: 1  GEFTLIGFEEISKLEKKNHVALIYGNINLLILKNKAVLVRIHSECLTGDALFSLRCDCGF 60

Query: 70 QLEAALTQIAEEGRGILLYHR 90
          QL+ ++  I+++G G+++YHR
Sbjct: 61 QLKQSMKIISKKGFGVIIYHR 81


>UniRef50_UPI0001C31D71 34-dihydroxy-2-butanone 4-phosphate synthase n=1 Tax=Conexibacter
           woesei DSM 14684 RepID=UPI0001C31D71
          Length = 344

 Score = 82.9 bits (204), Expect = 5e-15,   Method: Composition-based stats.
 Identities = 41/143 (28%), Positives = 60/143 (41%), Gaps = 17/143 (11%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDALFS 62
           ++RV E  LP P G F  +G+E  A   DHVAL  GD +        VH  C  G+AL  
Sbjct: 216 VRRVVETALPLPAGPFRAIGYESAAGAADHVALALGDPAAPGAPRF-VHLRC-GGEALG- 272

Query: 63  LRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLG 122
             C C  +L++AL +IA  G G+L     E R         +   Q +   +        
Sbjct: 273 -LCGCRARLDSALAEIAAAGDGVLAVLAGEDR--------PSITTQPRCATSASPQELPR 323

Query: 123 FAADERDFTLCADMFKLLGVNEV 145
             A      +   +F  LG+ ++
Sbjct: 324 LLA-----GIARSIFGDLGIRDL 341


>UniRef50_O68249 3,4-dihydroxy-2-butanone 4-phosphate synthase n=18
           Tax=Epsilonproteobacteria RepID=RIBB_DEHMU
          Length = 356

 Score = 76.8 bits (188), Expect = 4e-13,   Method: Composition-based stats.
 Identities = 30/168 (17%), Positives = 67/168 (39%), Gaps = 39/168 (23%)

Query: 3   LKRVAEAKLPTPW-G-DFLMVGFEELATGHDHVALVYGDISGHTPVLARVHSECLTGDAL 60
           ++ +AE+   T + G D     F +    H H+A  +G+I   +    + HS     + L
Sbjct: 216 IRVIAEST--TQFLGKDARRYDFVDHNDNH-HIAYAFGNIKNRSA--VKFHSIMPDNELL 270

Query: 61  FSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQ 120
              +      L  A+  + + G G+L++          ++KI                  
Sbjct: 271 ADTKK--YNSLIQAIHYLQKSG-GVLIFMDN---GTQDMSKI------------------ 306

Query: 121 LGFAADERDFTLCADMFKLLGVNEVRLLTNNPKK-VEILTEAGINIVE 167
                  R++ + A + K LG+  + LL+++  K    ++  G+++++
Sbjct: 307 -------REYGIGAQIIKHLGIENIELLSDSKNKEFVGISGFGLSVIK 347


>UniRef50_Q9ZL40 3,4-dihydroxy-2-butanone 4-phosphate synthase n=23
           Tax=Epsilonproteobacteria RepID=RIBB_HELPJ
          Length = 344

 Score = 73.7 bits (180), Expect = 3e-12,   Method: Composition-based stats.
 Identities = 29/156 (18%), Positives = 51/156 (32%), Gaps = 35/156 (22%)

Query: 19  LMVGFEELATG-HDHVAL-VYGDISGHTPVLARVHSECLTGDALFSLRCDCGFQLEAALT 76
               +  L     +H A    G  +     L R H      +    L          AL 
Sbjct: 221 QTQCYTFLDHQQKNHYAFKFKGAKTHDLAPLVRFH---PIKEDFDFLTTGAFEAFFKALE 277

Query: 77  QIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANHQLGFAADERDFTLCADM 136
            +  EG G L++         ++                            +DF + A +
Sbjct: 278 YLKREG-GYLIFMNTHSEQNNIV----------------------------KDFGIGALV 308

Query: 137 FKLLGVNEVRLLTN-NPKKVEILTEAGINIVERVPL 171
            K LGV + RLL++   ++ + L+  G+ +VE + L
Sbjct: 309 LKNLGVKDFRLLSSCEDRQYKALSGFGLKLVETISL 344


>UniRef50_Q9PHU4 3,4-dihydroxy-2-butanone 4-phosphate synthase n=14
           Tax=Campylobacter RepID=RIBB_CAMJE
          Length = 339

 Score = 72.2 bits (176), Expect = 1e-11,   Method: Composition-based stats.
 Identities = 27/166 (16%), Positives = 60/166 (36%), Gaps = 40/166 (24%)

Query: 1   MQLKRVAEAKLPTPWGDFLMVGFEELATGH-DHVALVYGDISGHTPVLARVHSECLTGDA 59
           ++L+  +++ L      F    F         H+A  + DI        + H      + 
Sbjct: 205 IKLEEKSQSVL----AGFKAEKFIFSDHNQTQHIAFCFKDIKKCEN--VKFHISGSDFEL 258

Query: 60  LFSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRAYALQDQGYDTVEANH 119
           L S   D   +L   +  ++E G G++++ + E          ++   Q           
Sbjct: 259 LTS---DKFSKLLEQIKFLSENG-GVIVFMQGE----------KSSTTQ----------- 293

Query: 120 QLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKK-VEILTEAGIN 164
                   +++ + A + +  G+ E++LL+ +  K    L   G+N
Sbjct: 294 -------YKNYGIGAQILRYFGIEEIKLLSQSCDKDYIGLEGFGLN 332


>UniRef50_A8HP30 Bifunctional GTP cyclohydrolase (Fragment) n=3 Tax=Eukaryota
           RepID=A8HP30_CHLRE
          Length = 390

 Score = 71.8 bits (175), Expect = 1e-11,   Method: Composition-based stats.
 Identities = 38/164 (23%), Positives = 57/164 (34%), Gaps = 23/164 (14%)

Query: 18  FLMVGFEELATGHDHVALVYGDI-SGHTPVLARVHSECLTGDALFSLRC--------DC- 67
                F     G +HVA V+G +    + VL  VH E    D L             DC 
Sbjct: 234 LTAQAFRNAVDGTEHVAFVHGAVADSASDVLLHVHHERTVADLLDCAAPGTSAGGAADCS 293

Query: 68  -----GFQLEAALTQIAEEGRGILLYHR-QEGRNIGLLNKIRAYALQDQGYDTVEANHQL 121
                   L+ AL  +A  G G+++Y R Q  R +    ++ A                 
Sbjct: 294 LPAANASSLDGALRSVAAAGAGVVVYLRGQSARGLPPSAELAALGSGGA-------GAGA 346

Query: 122 GFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAGINI 165
            ++ D +D  + A M + LGV  V L          L   G+ +
Sbjct: 347 LYSCDLKDAAVVAQMLRQLGVRSVSLAGGEGAMATALRSCGLAV 390


>UniRef50_Q0E2P5 Os02g0223200 protein (Fragment) n=2 Tax=Oryza sativa Japonica Group
           RepID=Q0E2P5_ORYSJ
          Length = 157

 Score = 68.7 bits (167), Expect = 1e-10,   Method: Composition-based stats.
 Identities = 22/68 (32%), Positives = 31/68 (45%), Gaps = 16/68 (23%)

Query: 103 RAYALQDQGYDTVEANHQLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVEILTEAG 162
           R Y L D G+DTV+AN +LG A D R++ + A +                 K   L    
Sbjct: 69  RTYNLLDDGHDTVQANVELGLAVDSREYGIGAQV----------------AKFVGLKGYR 112

Query: 163 INIVERVP 170
           + +V RVP
Sbjct: 113 LAVVGRVP 120


>UniRef50_Q9APK4 GTP cyclohydrolase-2 (Fragment) n=1 Tax=Hyphomicrobium
          chloromethanicum RepID=Q9APK4_9RHIZ
          Length = 68

 Score = 58.3 bits (140), Expect = 1e-07,   Method: Composition-based stats.
 Identities = 18/57 (31%), Positives = 27/57 (47%), Gaps = 2/57 (3%)

Query: 17 DFLMVGFEELATGHDHVALVYG--DISGHTPVLARVHSECLTGDALFSLRCDCGFQL 71
           F    F       + + L++    I+  +  L  +HS CL GDA  S+RCDC  +L
Sbjct: 12 SFEARAFLGPTEDEEALVLIHQQVPIAPDSEPLVYIHSGCLVGDAFHSMRCDCRRRL 68


>UniRef50_Q2GW54 Putative uncharacterized protein n=1 Tax=Chaetomium globosum
           RepID=Q2GW54_CHAGB
          Length = 480

 Score = 56.0 bits (134), Expect = 7e-07,   Method: Composition-based stats.
 Identities = 18/88 (20%), Positives = 31/88 (35%), Gaps = 8/88 (9%)

Query: 102 IRAYALQDQG----YDTVEANHQLGFAADERDFTLCADMFKLLGVNEV-RLLTNNPKKVE 156
              Y  + +G     D  +    +    D R   L  D+   LG+ ++ R+L+ +     
Sbjct: 340 YLVYNARKRGEDRASDYFKRTENIAGVKDMRFQALMPDILHWLGITKIDRMLSMSNSSET 399

Query: 157 ILTE---AGINIVERVPLIVGRNPNNEH 181
              +     I I ERV L     P +  
Sbjct: 400 GNADGPSHSIPIHERVELPESWIPADSR 427


>UniRef50_UPI0001B53FE8 hypothetical protein StAA4_17215 n=1 Tax=Streptomyces sp. AA4
           RepID=UPI0001B53FE8
          Length = 83

 Score = 54.8 bits (131), Expect = 1e-06,   Method: Composition-based stats.
 Identities = 15/37 (40%), Positives = 23/37 (62%)

Query: 120 QLGFAADERDFTLCADMFKLLGVNEVRLLTNNPKKVE 156
           +LG  AD R++   A +   LGV+  ++LTNNP K+ 
Sbjct: 38  RLGEPADAREYGAAAAILLDLGVSRAQVLTNNPGKLR 74


>UniRef50_C7MUB0 3,4-dihydroxy-2-butanone 4-phosphate synthase n=1
           Tax=Saccharomonospora viridis DSM 43017
           RepID=C7MUB0_SACVD
          Length = 403

 Score = 53.7 bits (128), Expect = 3e-06,   Method: Composition-based stats.
 Identities = 16/49 (32%), Positives = 29/49 (59%), Gaps = 1/49 (2%)

Query: 2   QLKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGHTPVLARV 50
           ++ R+A  +LPT  G+   +G+ +  TG +H+AL+ G+ +  T  L  V
Sbjct: 233 RVTRMAHTRLPTRHGELRAIGYRDDVTGAEHLALL-GEPTPGTYPLVAV 280


>UniRef50_B7FLV1 Putative uncharacterized protein n=1 Tax=Medicago truncatula
           RepID=B7FLV1_MEDTR
          Length = 231

 Score = 52.9 bits (126), Expect = 6e-06,   Method: Composition-based stats.
 Identities = 15/41 (36%), Positives = 22/41 (53%)

Query: 3   LKRVAEAKLPTPWGDFLMVGFEELATGHDHVALVYGDISGH 43
           ++R   A +PT WG F    +  L  G +H+A+V GDI   
Sbjct: 190 VERAGAALIPTMWGPFEANCYRSLLDGMEHIAMVKGDIGDG 230


>UniRef50_D0NPB4 Riboflavin biosynthesis protein ribBA, putative n=2
           Tax=Phytophthora infestans T30-4 RepID=D0NPB4_PHYIN
          Length = 329

 Score = 41.7 bits (97), Expect = 0.012,   Method: Composition-based stats.
 Identities = 27/104 (25%), Positives = 47/104 (45%), Gaps = 13/104 (12%)

Query: 3   LKRVAE-AKLPTPWGDFLMVGFEELA-TGHDHVALVYGDISGHTPVLARVHSECLTGDAL 60
           ++R+ E +K+ TP G+F  V ++ L      + ALVYGD+     VL       L  D  
Sbjct: 220 VQRIDEQSKVTTPLGEFASVAYKSLVQENQTYHALVYGDVD-GKDVLV-----FLVEDGF 273

Query: 61  FSLRCDCGFQLEAALTQIAEEGRGILLYHRQEGRNIGLLNKIRA 104
                +   Q + A   +A  G G+L+Y     + + +  ++ A
Sbjct: 274 -----EASLQAQWAQKFVATHGYGVLIYIHGSEQLLQISGELMA 312


>UniRef50_A6RFL8 GTP cyclohydrolase-2 n=1 Tax=Ajellomyces capsulatus NAm1
           RepID=A6RFL8_AJECN
          Length = 209

 Score = 40.6 bits (94), Expect = 0.027,   Method: Composition-based stats.
 Identities = 9/38 (23%), Positives = 22/38 (57%), Gaps = 1/38 (2%)

Query: 2   QLKRVAEAKLPTPWG-DFLMVGFEELATGHDHVALVYG 38
           +++ +  A++PT  G +  +  +   A   +H+A+V+G
Sbjct: 106 KVECIVRARIPTTGGAEMFLHLYHNDADNKEHLAIVFG 143


>UniRef50_UPI0001699144 3,4-dihydroxy-2-butanone 4-phosphate synthase / GTP
          cyclohydrolase II n=1 Tax=Endoriftia persephone
          'Hot96_1+Hot96_2' RepID=UPI0001699144
          Length = 60

 Score = 39.4 bits (91), Expect = 0.060,   Method: Composition-based stats.
 Identities = 10/27 (37%), Positives = 17/27 (62%)

Query: 66 DCGFQLEAALTQIAEEGRGILLYHRQE 92
          DCG+ L  A+ Q++E G G+++  R  
Sbjct: 10 DCGWPLANAMKQVSEAGEGVIVVLRNH 36


  Database: uniref50.fasta
    Posted date:  Mar 8, 2010 10:38 AM
  Number of letters in database: 1,040,396,356
  Number of sequences in database:  3,077,464
  
Lambda     K      H
   0.313    0.159    0.494 

Lambda     K      H
   0.267   0.0489    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 1,517,409,939
Number of Sequences: 3077464
Number of extensions: 74238175
Number of successful extensions: 146748
Number of sequences better than 1.0e-01: 172
Number of HSP's better than  0.1 without gapping: 464
Number of HSP's successfully gapped in prelim test: 33
Number of HSP's that attempted gapping in prelim test: 145533
Number of HSP's gapped (non-prelim): 552
length of query: 196
length of database: 1,040,396,356
effective HSP length: 122
effective length of query: 74
effective length of database: 664,945,748
effective search space: 49205985352
effective search space used: 49205985352
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.2 bits)
S2: 90 (39.0 bits)
