BLASTP 2.2.22 [Sep-27-2009]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.


Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.


Reference for composition-based statistics starting in round 2:
Schaffer, Alejandro A., L. Aravind, Thomas L. Madden,
Sergei Shavirin, John L. Spouge, Yuri I. Wolf,  
Eugene V. Koonin, and Stephen F. Altschul (2001), 
"Improving the accuracy of PSI-BLAST protein database searches with 
composition-based statistics and other refinements",  Nucleic Acids Res. 29:2994-3005.

Query= batch____
         (434 letters)

Database: uniref50.fasta 
           3,077,464 sequences; 1,040,396,356 total letters

Searching..................................................done


Results from round 1


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

UniRef50_Q5E638 Histidinol dehydrogenase n=29 Tax=Bacteria RepID...   565   e-159
UniRef50_Q4QN74 Histidinol dehydrogenase n=38 Tax=cellular organ...   555   e-157
UniRef50_Q492K3 Histidinol dehydrogenase n=542 Tax=Proteobacteri...   506   e-142
UniRef50_P59398 Histidinol dehydrogenase n=5 Tax=Buchnera aphidi...   473   e-132
UniRef50_D1PYE8 Histidinol dehydrogenase n=2 Tax=Prevotella RepI...   420   e-116
UniRef50_C7NG13 Histidinol dehydrogenase n=2 Tax=Bacteria RepID=...   414   e-114
UniRef50_D1IQ57 Histidinol dehydrogenase (Fragment) n=1 Tax=Viti...   392   e-107
UniRef50_UPI00019859BD PREDICTED: hypothetical protein n=1 Tax=V...   390   e-107
UniRef50_Q87C29 Histidinol dehydrogenase n=66 Tax=cellular organ...   390   e-107
UniRef50_Q9C5U8 Histidinol dehydrogenase, chloroplastic n=34 Tax...   389   e-107
UniRef50_C6Y3G2 Histidinol dehydrogenase n=6 Tax=cellular organi...   387   e-106
UniRef50_B2KCM4 Histidinol dehydrogenase n=1 Tax=Elusimicrobium ...   385   e-105
UniRef50_B0TY46 Histidinol dehydrogenase n=2 Tax=Francisella phi...   382   e-104
UniRef50_D0JBA3 Histidinol dehydrogenase n=2 Tax=Blattabacterium...   381   e-104
UniRef50_Q2PPB3 Histidine biosynthesis trifunctional protein n=1...   377   e-103
UniRef50_P00815 Histidinol dehydrogenase n=17 Tax=cellular organ...   373   e-102
UniRef50_Q4P7D9 Putative uncharacterized protein n=3 Tax=Eukaryo...   367   e-100
UniRef50_Q9P777 Histidinol dehydrogenase n=71 Tax=cellular organ...   361   3e-98
UniRef50_D1CF70 Histidinol dehydrogenase n=1 Tax=Thermobaculum t...   358   2e-97
UniRef50_Q5ZW87 Histidinol dehydrogenase n=6 Tax=Legionella RepI...   357   6e-97
UniRef50_A9NV24 Histidinol dehydrogenase n=2 Tax=Spermatophyta R...   354   3e-96
UniRef50_B4W8G9 Histidinol dehydrogenase n=2 Tax=Caulobacteracea...   342   1e-92
UniRef50_Q8R882 Histidinol dehydrogenase n=7 Tax=Clostridia RepI...   342   1e-92
UniRef50_O26327 Histidinol dehydrogenase n=6 Tax=Euryarchaeota R...   340   5e-92
UniRef50_Q465R4 Histidinol dehydrogenase n=7 Tax=Euryarchaeota R...   332   1e-89
UniRef50_A1ZJE8 Histidinol dehydrogenase n=1 Tax=Microscilla mar...   330   8e-89
UniRef50_Q2HFX2 Putative uncharacterized protein n=1 Tax=Chaetom...   330   9e-89
UniRef50_A8RCE7 Putative uncharacterized protein n=1 Tax=Eubacte...   325   3e-87
UniRef50_Q58851 Histidinol dehydrogenase n=16 Tax=Euryarchaeota ...   323   9e-87
UniRef50_Q2NHT1 HisD n=1 Tax=Methanosphaera stadtmanae DSM 3091 ...   321   3e-86
UniRef50_D0XPF3 Histidinol dehydrogenase n=1 Tax=Brevundimonas s...   318   2e-85
UniRef50_P62456 Histidinol dehydrogenase n=127 Tax=Bacteria RepI...   314   5e-84
UniRef50_Q722Y3 Histidinol dehydrogenase n=20 Tax=Firmicutes Rep...   310   6e-83
UniRef50_Q8YSM8 Histidinol dehydrogenase 1 n=16 Tax=Bacteria Rep...   309   1e-82
UniRef50_B3WED5 Histidinol dehydrogenase n=21 Tax=Bacilli RepID=...   309   1e-82
UniRef50_P59399 Histidinol dehydrogenase n=14 Tax=Bacteria RepID...   309   1e-82
UniRef50_D1YWF4 Histidinol dehydrogenase n=1 Tax=Methanocella pa...   305   3e-81
UniRef50_Q46J19 Histidinol dehydrogenase n=60 Tax=Bacteria RepID...   305   3e-81
UniRef50_Q39YP7 Histidinol dehydrogenase n=54 Tax=Bacteria RepID...   305   3e-81
UniRef50_Q1Q2D0 Histidinol dehydrogenase n=1 Tax=Candidatus Kuen...   304   4e-81
UniRef50_Q5FS83 Histidinol dehydrogenase n=3 Tax=Bacteria RepID=...   303   8e-81
UniRef50_Q64EP7 Histidinol dehydrogenase n=2 Tax=environmental s...   303   9e-81
UniRef50_Q02136 Histidinol dehydrogenase n=9 Tax=Bacteria RepID=...   301   4e-80
UniRef50_C0QG33 Histidinol dehydrogenase n=4 Tax=Deltaproteobact...   300   8e-80
UniRef50_C0GFZ9 Histidinol dehydrogenase n=1 Tax=Dethiobacter al...   300   8e-80
UniRef50_Q1IKB6 Histidinol dehydrogenase n=1 Tax=Candidatus Kori...   299   2e-79
UniRef50_Q186D5 Histidinol dehydrogenase n=9 Tax=Bacteria RepID=...   298   2e-79
UniRef50_Q30TA4 Histidinol dehydrogenase n=16 Tax=Epsilonproteob...   298   4e-79
UniRef50_D0LM64 Histidinol dehydrogenase n=2 Tax=Nannocystineae ...   296   8e-79
UniRef50_D2RJQ0 Histidinol dehydrogenase n=7 Tax=Firmicutes RepI...   296   1e-78
UniRef50_B2A652 Histidinol dehydrogenase n=1 Tax=Natranaerobius ...   295   3e-78
UniRef50_Q46WL2 Histidinol dehydrogenase 1 n=202 Tax=Bacteria Re...   293   8e-78
UniRef50_Q4ZNV9 Histidinol dehydrogenase n=116 Tax=Bacteria RepI...   292   1e-77
UniRef50_Q6FEC8 Histidinol dehydrogenase n=50 Tax=Bacteria RepID...   290   5e-77
UniRef50_P62460 Histidinol dehydrogenase n=15 Tax=Bacteria RepID...   290   1e-76
UniRef50_Q4FQF8 Histidinol dehydrogenase n=6 Tax=Proteobacteria ...   289   1e-76
UniRef50_B9KYT3 Histidinol dehydrogenase n=1 Tax=Thermomicrobium...   289   1e-76
UniRef50_B9D1F9 Histidinol dehydrogenase n=2 Tax=Campylobacter R...   289   2e-76
UniRef50_Q01ZU1 Histidinol dehydrogenase n=1 Tax=Candidatus Soli...   288   3e-76
UniRef50_B3DXR9 Histidinol dehydrogenase n=1 Tax=Methylacidiphil...   288   4e-76
UniRef50_A9A0A6 Histidinol dehydrogenase n=2 Tax=Desulfobacterac...   287   5e-76
UniRef50_B1YL14 Histidinol dehydrogenase n=1 Tax=Exiguobacterium...   287   7e-76
UniRef50_B3TCH3 Putative Histidinol dehydrogenase n=1 Tax=uncult...   287   7e-76
UniRef50_C4V2I6 Histidinol dehydrogenase n=1 Tax=Selenomonas flu...   286   2e-75
UniRef50_Q3J079 Histidinol dehydrogenase 1 n=26 Tax=Proteobacter...   284   5e-75
UniRef50_P62457 Histidinol dehydrogenase n=27 Tax=cellular organ...   283   9e-75
UniRef50_C8WUX6 Histidinol dehydrogenase n=2 Tax=Alicyclobacillu...   283   1e-74
UniRef50_D0RRH1 Histidinol dehydrogenase n=1 Tax=alpha proteobac...   283   1e-74
UniRef50_C9LTV1 Histidinol dehydrogenase n=1 Tax=Selenomonas spu...   281   4e-74
UniRef50_P73058 Histidinol dehydrogenase 1 n=11 Tax=Cyanobacteri...   280   5e-74
UniRef50_Q9X0D1 Histidinol dehydrogenase n=6 Tax=Thermotogaceae ...   280   7e-74
UniRef50_Q0AP81 Histidinol dehydrogenase, Histidinol-phosphatase...   280   8e-74
UniRef50_C9RN89 Histidinol dehydrogenase n=1 Tax=Fibrobacter suc...   280   9e-74
UniRef50_Q8TXG3 Histidinol dehydrogenase n=1 Tax=Methanopyrus ka...   277   5e-73
UniRef50_D1N997 Histidinol dehydrogenase n=2 Tax=Lentisphaerae R...   275   2e-72
UniRef50_Q3ZXL7 Histidinol dehydrogenase n=5 Tax=Dehalococcoides...   275   2e-72
UniRef50_C9KKX1 Histidinol dehydrogenase n=1 Tax=Mitsuokella mul...   274   4e-72
UniRef50_UPI00017455E1 Histidinol dehydrogenase n=1 Tax=Verrucom...   274   6e-72
UniRef50_C1PFR7 Histidinol dehydrogenase n=1 Tax=Bacillus coagul...   273   1e-71
UniRef50_Q313T7 Histidinol dehydrogenase n=7 Tax=Deltaproteobact...   272   2e-71
UniRef50_B3T638 Histidinol dehydrogenase n=1 Tax=uncultured mari...   271   5e-71
UniRef50_A5D1M4 Histidinol dehydrogenase n=1 Tax=Pelotomaculum t...   270   1e-70
UniRef50_C1FAE2 Histidinol dehydrogenase n=1 Tax=Acidobacterium ...   269   1e-70
UniRef50_A6UA68 Histidinol dehydrogenase n=4 Tax=Proteobacteria ...   269   2e-70
UniRef50_B2UMH6 Histidinol dehydrogenase n=3 Tax=Verrucomicrobia...   267   7e-70
UniRef50_B6A0U7 Histidinol dehydrogenase n=1 Tax=Rhizobium legum...   267   7e-70
UniRef50_Q1D4L9 Histidinol dehydrogenase n=2 Tax=Cystobacterinea...   266   9e-70
UniRef50_Q4A044 Histidinol dehydrogenase n=62 Tax=Staphylococcus...   265   2e-69
UniRef50_Q3IQR5 Histidinol dehydrogenase n=10 Tax=Halobacteriace...   265   2e-69
UniRef50_A3EUM9 Histidinol dehydrogenase n=3 Tax=Leptospirillum ...   264   4e-69
UniRef50_B1H0F0 Histidinol dehydrogenase n=1 Tax=uncultured Term...   264   6e-69
UniRef50_UPI00016BFCCC histidinol dehydrogenase n=1 Tax=Epulopis...   264   6e-69
UniRef50_D2RSH8 Histidinol dehydrogenase n=1 Tax=Haloterrigena t...   263   1e-68
UniRef50_Q7UX39 Histidinol dehydrogenase n=6 Tax=Planctomycetace...   259   1e-67
UniRef50_Q5JFR5 Histidinol dehydrogenase n=9 Tax=cellular organi...   259   1e-67
UniRef50_Q67KH6 Histidinol dehydrogenase n=1 Tax=Symbiobacterium...   258   3e-67
UniRef50_D1B7M0 Histidinol dehydrogenase n=2 Tax=Bacteria RepID=...   257   7e-67
UniRef50_C7LV94 Histidinol dehydrogenase n=6 Tax=Desulfovibriona...   256   8e-67
UniRef50_C4L171 Histidinol dehydrogenase n=1 Tax=Exiguobacterium...   256   2e-66
UniRef50_A9A5X6 Histidinol dehydrogenase n=2 Tax=Thaumarchaeota ...   255   2e-66
UniRef50_C3XDE7 Histidinol dehydrogenase n=1 Tax=Helicobacter bi...   255   2e-66
UniRef50_Q3AR25 Histidinol dehydrogenase n=13 Tax=Bacteria RepID...   254   4e-66
UniRef50_Q1AX10 Histidinol dehydrogenase n=1 Tax=Rubrobacter xyl...   253   7e-66
UniRef50_Q5WIU9 Histidinol dehydrogenase 1 n=52 Tax=cellular org...   253   1e-65
UniRef50_Q3B5E3 Histidinol dehydrogenase n=8 Tax=Chlorobiaceae R...   252   2e-65
UniRef50_Q4FNE2 Histidinol dehydrogenase 1 n=3 Tax=Candidatus Pe...   252   2e-65
UniRef50_B0S9F2 Histidinol dehydrogenase n=6 Tax=Leptospira RepI...   250   9e-65
UniRef50_C9SQK1 Histidine biosynthesis trifunctional protein n=1...   249   2e-64
UniRef50_Q483H8 Histidinol dehydrogenase 2 n=15 Tax=Proteobacter...   247   6e-64
UniRef50_O33775 Histidinol dehydrogenase n=12 Tax=Sulfolobaceae ...   244   6e-63
UniRef50_D2R570 Histidinol dehydrogenase n=1 Tax=Pirellula stale...   243   8e-63
UniRef50_Q4JW59 Histidinol dehydrogenase n=104 Tax=Actinobacteri...   242   2e-62
UniRef50_A0R401 Histidinol dehydrogenase n=2 Tax=Actinomycetales...   239   1e-61
UniRef50_A9G5W4 HisD protein n=1 Tax=Sorangium cellulosum 'So ce...   239   2e-61
UniRef50_C0G418 Histidinol dehydrogenase n=2 Tax=Rhizobiales Rep...   238   3e-61
UniRef50_C7LZ86 Histidinol dehydrogenase n=1 Tax=Acidimicrobium ...   238   4e-61
UniRef50_A4QA32 Histidinol dehydrogenase n=16 Tax=cellular organ...   236   1e-60
UniRef50_Q5YYQ0 Histidinol dehydrogenase n=8 Tax=Actinomycetales...   236   1e-60
UniRef50_Q82AA6 Histidinol dehydrogenase n=29 Tax=Actinobacterid...   231   6e-59
UniRef50_A3Q131 Histidinol dehydrogenase n=6 Tax=Mycobacterium R...   230   8e-59
UniRef50_Q13I58 Histidinol dehydrogenase n=22 Tax=cellular organ...   224   7e-57
UniRef50_B1ZNB2 Histidinol dehydrogenase n=3 Tax=Verrucomicrobia...   220   8e-56
UniRef50_C1A4M1 Histidinol dehydrogenase n=1 Tax=Gemmatimonas au...   220   1e-55
UniRef50_Q46N53 Histidinol dehydrogenase 2 n=50 Tax=root RepID=H...   215   2e-54
UniRef50_C7RAI8 Histidinol dehydrogenase n=1 Tax=Kangiella koree...   214   4e-54
UniRef50_C0GVA3 Histidinol dehydrogenase n=1 Tax=Desulfonatronos...   209   1e-52
UniRef50_B7FPZ7 Histidinol dehydrogenase (Fragment) n=3 Tax=Euka...   208   3e-52
UniRef50_B5YLM0 Histidinol dehydrogenase n=1 Tax=Thalassiosira p...   205   3e-51
UniRef50_B5YE85 Histidinol dehydrogenase n=1 Tax=Dictyoglomus th...   202   2e-50
UniRef50_B8E2C3 Histidinol dehydrogenase n=1 Tax=Dictyoglomus tu...   201   5e-50
UniRef50_UPI0001C3165E histidinol dehydrogenase n=1 Tax=Conexiba...   192   2e-47
UniRef50_B9NIZ3 Histidinol dehydrogenase n=1 Tax=Populus trichoc...   189   2e-46
UniRef50_A8M914 Histidinol dehydrogenase n=1 Tax=Caldivirga maqu...   186   2e-45
UniRef50_C6UN35 Histidinal/histidinol dehydrogenase n=1 Tax=Cand...   177   1e-42
UniRef50_A8A9G5 Histidinol dehydrogenase n=1 Tax=Ignicoccus hosp...   167   8e-40
UniRef50_Q8ZY17 Histidinol dehydrogenase n=5 Tax=Thermoproteacea...   123   1e-26
UniRef50_P72946 Putative histidinol dehydrogenase 2 n=1 Tax=Syne...   115   2e-24
UniRef50_A3J633 Histidinol dehydrogenase (Fragment) n=1 Tax=Flav...   105   3e-21
UniRef50_B8NVQ6 Histidinol dehydrogenase, putative n=1 Tax=Asper...   105   4e-21
UniRef50_UPI0001909A69 histidinol dehydrogenase n=1 Tax=Rhizobiu...   101   6e-20
UniRef50_C7H2J0 Histidinol dehydrogenase n=1 Tax=Faecalibacteriu...    99   3e-19
UniRef50_C5GHZ5 Histidinol dehydrogenase n=2 Tax=Ajellomyces der...    92   5e-17
UniRef50_D1ND55 Histidinol dehydrogenase (Fragment) n=1 Tax=Haem...    76   2e-12
UniRef50_B4CYY3 NAD+ oxidoreductase n=1 Tax=Chthoniobacter flavu...    62   5e-08
UniRef50_UPI0001696B01 histidinol dehydrogenase n=2 Tax=Listeria...    61   8e-08
UniRef50_D1KBK9 Histidinol dehydrogenase n=1 Tax=uncultured SUP0...    44   0.008

>UniRef50_Q5E638 Histidinol dehydrogenase n=29 Tax=Bacteria RepID=HISX_VIBF1
          Length = 439

 Score =  565 bits (1456), Expect = e-159,   Method: Compositional matrix adjust.
 Identities = 275/424 (64%), Positives = 327/424 (77%)

Query: 9   WNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKV 68
           W S +  QQ  +L RPAI+   +IT  V  +++ VK  GD  +   + KFD     +++V
Sbjct: 6   WQSLSDSQQDTVLQRPAITEGANITAAVTSVINTVKQEGDAGVFALTEKFDGVKPDSIRV 65

Query: 69  SAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVG 128
           S  EI AAS+RLS+E+K A+  A  NI  FH AQK  PV VETQPGV C+Q+T P+  VG
Sbjct: 66  SNAEIEAASDRLSEEMKTALKQAYSNISKFHQAQKPQPVKVETQPGVICEQITMPINKVG 125

Query: 129 LYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVFNVGGAQ 188
           LYIPGGSAPL STVLML  PA IAGC KVVLCSPPPIADEILY A+LC + +V+N+GGAQ
Sbjct: 126 LYIPGGSAPLPSTVLMLGIPAQIAGCHKVVLCSPPPIADEILYVAKLCKIDEVYNIGGAQ 185

Query: 189 AIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGAT 248
           A+AA+A+GTESV KVDKIFGPGNA+VTEAKRQVS    GAAIDMPAGPSEVLVIAD  A 
Sbjct: 186 AVAAMAYGTESVSKVDKIFGPGNAYVTEAKRQVSNDFRGAAIDMPAGPSEVLVIADESAD 245

Query: 249 PDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLI 308
           PDF+A+DLLSQAEHGPDSQV+L+TP+  +A +VA+AVERQL EL R + ARQAL +S LI
Sbjct: 246 PDFIAADLLSQAEHGPDSQVVLVTPSPIIADQVADAVERQLKELSREDIARQALGSSLLI 305

Query: 309 VTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHV 368
           V   L QCV ISN YGPEHLI+QT+N REL+  + +AGS+FLGD+SPESAGDYASGTNHV
Sbjct: 306 VADSLTQCVSISNFYGPEHLIVQTKNPRELLPLLDNAGSIFLGDYSPESAGDYASGTNHV 365

Query: 369 LPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVN 428
           LPTYGYT T SSLGLADF KRMTVQEL+ +G   LA T+ T+A AE L AHK AVT+R+ 
Sbjct: 366 LPTYGYTRTYSSLGLADFSKRMTVQELTADGLKGLAPTVVTMAEAEGLDAHKRAVTIRIE 425

Query: 429 ALKE 432
            L +
Sbjct: 426 KLAQ 429


>UniRef50_Q4QN74 Histidinol dehydrogenase n=38 Tax=cellular organisms
           RepID=HISX_HAEI8
          Length = 427

 Score =  555 bits (1431), Expect = e-157,   Method: Compositional matrix adjust.
 Identities = 274/428 (64%), Positives = 330/428 (77%), Gaps = 3/428 (0%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
             TII WN  +  ++R+++MRP     E+I + VN I +NV   GD AL E   KFD   
Sbjct: 1   MQTII-WNHLSETEKRKVIMRPVQQNGENIQQAVNAIRENVAYNGDRALFELCEKFDGVK 59

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
           +  L VSA+EI AAS R+S +L+ A+  A  NIE FH AQ+   +D+E Q GVRCQ VTR
Sbjct: 60  LDKLIVSADEIQAASSRISVKLRNAIEQAKTNIEAFHKAQQNQEIDLEIQEGVRCQVVTR 119

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVF 182
           P++ VGLYIPGGSAPLFSTVLMLA PA IAGCKK+VLCSPPPI+DEILY A LCGV+ ++
Sbjct: 120 PISCVGLYIPGGSAPLFSTVLMLAIPAKIAGCKKIVLCSPPPISDEILYTAHLCGVETIY 179

Query: 183 NVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVI 242
            +GGAQA+ A+A GTESV KVDKIFGPGNAFVTEAKRQV+Q  +  AIDMPAGPSEVLVI
Sbjct: 180 AIGGAQAVFAMAQGTESVAKVDKIFGPGNAFVTEAKRQVAQ--NSTAIDMPAGPSEVLVI 237

Query: 243 ADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL 302
           AD  A P+FVASDLLSQAEHG DSQVIL+     +A+  A A+ERQLA LPRAETAR+AL
Sbjct: 238 ADESADPEFVASDLLSQAEHGADSQVILVATCETLAKETALAIERQLALLPRAETARKAL 297

Query: 303 NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYA 362
           N SR+ + + L Q VEISN+Y PEHLI+QT+NAR+L+  + +AGS+FLG +SPES GDYA
Sbjct: 298 NHSRIFIAESLEQAVEISNEYAPEHLIVQTKNARKLLPYLDNAGSIFLGAYSPESMGDYA 357

Query: 363 SGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNA 422
           SGTNHVLPTYGYT T SSLGLADF KRMTVQEL+ +GF  LA T+E +A AE+L AHK A
Sbjct: 358 SGTNHVLPTYGYTKTYSSLGLADFSKRMTVQELTPKGFKNLAETVEVMAEAEQLAAHKMA 417

Query: 423 VTLRVNAL 430
           V++R+  L
Sbjct: 418 VSVRLAKL 425


>UniRef50_Q492K3 Histidinol dehydrogenase n=542 Tax=Proteobacteria RepID=HISX_BLOPB
          Length = 443

 Score =  506 bits (1304), Expect = e-142,   Method: Compositional matrix adjust.
 Identities = 232/427 (54%), Positives = 305/427 (71%)

Query: 7   IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTAL 66
           I WN C+  +Q++LL RP  +    I   V +IL  V   GD AL +++  FD    T L
Sbjct: 10  IYWNDCSKSEQKKLLTRPINNKLNDIYINVKNILTKVYNEGDRALFKFNFDFDNVQTTQL 69

Query: 67  KVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVAS 126
           ++  E I  +   LS+E+KQA+  A+ NI  FH AQ    + VET PGV CQQ+ RP+  
Sbjct: 70  QIPTEIIMNSGRNLSNEIKQAIHTAMTNITRFHQAQCYSEIIVETLPGVYCQQIIRPLNI 129

Query: 127 VGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVFNVGG 186
           VGLY+PGG+APL STV+ML  PA IA CK+V+LCSPPPI D I+Y AQLCG+ +++ +GG
Sbjct: 130 VGLYVPGGTAPLLSTVMMLGVPARIAKCKRVILCSPPPIPDVIIYTAQLCGIDEIYQIGG 189

Query: 187 AQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSG 246
           +Q+IAA+ FGTES+PKVDKIFGPGN +VTEAKRQ++   +GAAIDM AGPSE+L+IAD+ 
Sbjct: 190 SQSIAAMGFGTESIPKVDKIFGPGNIWVTEAKRQINLAPNGAAIDMLAGPSEILIIADNT 249

Query: 247 ATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASR 306
           A P F+A+DLLSQ+EHGPDS  IL+TP + +A +  + + +QL  LPR +  R  L  SR
Sbjct: 250 ANPIFIAADLLSQSEHGPDSHAILITPYSCIAEKTKKELHKQLKILPRNDIVRNVLLNSR 309

Query: 307 LIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTN 366
           +I+T +L +C  ISN Y PEHLIIQ  NA + +  IT+AGS+FLG+WSPE+AGDYASG N
Sbjct: 310 MIITNNLMECFSISNSYAPEHLIIQIENASDYLHYITNAGSIFLGNWSPETAGDYASGPN 369

Query: 367 HVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
           HVLPTYG     S LG+ DFQKRM+VQ+L++ G   L+STI TL   E+L AH+ A+T R
Sbjct: 370 HVLPTYGRAVATSGLGVIDFQKRMSVQQLTQNGLLQLSSTITTLTQIEQLKAHEYAITHR 429

Query: 427 VNALKEQ 433
           +N +KEQ
Sbjct: 430 INYIKEQ 436


>UniRef50_P59398 Histidinol dehydrogenase n=5 Tax=Buchnera aphidicola
           RepID=HISX_BUCBP
          Length = 435

 Score =  473 bits (1216), Expect = e-132,   Method: Compositional matrix adjust.
 Identities = 215/427 (50%), Positives = 304/427 (71%)

Query: 6   IIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA 65
           II W SC+ +++R++L RP ++ +  I   V +I+ NVK  GD+AL +Y+  FDK  + +
Sbjct: 7   IIYWKSCSEKEKREILFRPVVNDNSQIKEVVKEIITNVKNSGDKALYDYTKTFDKIRLES 66

Query: 66  LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVA 125
           ++VS  EI  +   +++E++++++VA  NI+ FH  Q    V++E QPGV C+Q+ RP+ 
Sbjct: 67  IQVSYGEIVDSDSFVNEEIQKSISVAKNNIKIFHEKQTHNVVNIEIQPGVFCRQIIRPIQ 126

Query: 126 SVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVFNVG 185
           SVGLYIPGG APL STVLMLA PA I GCK ++LCSPPPI  EILYA+++CG+ ++F VG
Sbjct: 127 SVGLYIPGGCAPLVSTVLMLAIPAKIVGCKNIILCSPPPITKEILYASKICGIHNIFQVG 186

Query: 186 GAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADS 245
           GAQAIAA+AFGT+++PKV+KIFGPGN +VTEAK Q++  L+  +IDM AGPSE+L+IAD 
Sbjct: 187 GAQAIAAMAFGTKTIPKVNKIFGPGNVYVTEAKLQINALLNDLSIDMLAGPSEILIIADF 246

Query: 246 GATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNAS 305
            A    +ASD LSQ EHG  SQ IL+TP+ D+A  V   +  QL  L R +   ++L  S
Sbjct: 247 KANACIIASDFLSQMEHGIYSQAILVTPSYDLACNVIFEINIQLKNLSRKKVINKSLKYS 306

Query: 306 RLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGT 365
           R+IVTK L +C EISN Y PEHLIIQ  N+  L+  + +AGS+FLG WS  ++GDY +GT
Sbjct: 307 RIIVTKTLLECFEISNLYAPEHLIIQCENSNRLLVYVINAGSIFLGRWSAVASGDYVTGT 366

Query: 366 NHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTL 425
           NHVLPTYG     S L + DFQK ++VQ+L ++G   ++S+I +L+  ER+ AH N++  
Sbjct: 367 NHVLPTYGSAIVNSGLTVMDFQKIISVQKLDQQGLIDVSSSIISLSEVERMDAHTNSIKQ 426

Query: 426 RVNALKE 432
           R+ AL++
Sbjct: 427 RLIALQD 433


>UniRef50_D1PYE8 Histidinol dehydrogenase n=2 Tax=Prevotella RepID=D1PYE8_9BACT
          Length = 444

 Score =  420 bits (1080), Expect = e-116,   Method: Compositional matrix adjust.
 Identities = 210/419 (50%), Positives = 283/419 (67%), Gaps = 7/419 (1%)

Query: 19  QLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASE 78
           ++L RP +  S+ +  TVN+IL +VK+RGDEA+R Y A FD+  +  L VS EEI  A  
Sbjct: 14  RILKRPHLDVSQ-LNETVNEILSDVKSRGDEAVRHYEALFDQADLGDLTVSDEEIDEAMS 72

Query: 79  RLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPL 138
            +S +LK+A+ +A  NI  FH +Q      VET  GV C Q +  +  VGLYIPGG+APL
Sbjct: 73  MVSTDLKEALELAYHNISKFHESQLFHGKMVETAQGVVCWQKSVAIEKVGLYIPGGTAPL 132

Query: 139 FSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQDVFNVGGAQAIAALA 194
           FSTVLMLATPA IAGCK +VLC+PP     I   IL AA + GV  +F  GG QAI A+A
Sbjct: 133 FSTVLMLATPAKIAGCKDIVLCTPPNHDGKIHPAILVAAHIAGVDRIFKAGGVQAIGAMA 192

Query: 195 FGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVAS 254
           +GT+++PKV KIFGPGN +V  AK+QVS  L   AIDMPAGPSEV VIAD G+  +FVA+
Sbjct: 193 YGTQTIPKVYKIFGPGNQYVMAAKQQVS--LHDVAIDMPAGPSEVCVIADEGSNAEFVAA 250

Query: 255 DLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLA 314
           DLLSQAEHG DSQV+L++ + ++   V   VERQL  LPR E A  AL  S+ ++  D+ 
Sbjct: 251 DLLSQAEHGSDSQVMLISTSDNLITEVRSQVERQLENLPRREIASDALKNSKFVLVHDMD 310

Query: 315 QCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGY 374
           + + +SN+Y PEHLI+ T N  E+ D + +AGSVF+G WS ESAGDYASGTNH LPT+ Y
Sbjct: 311 EAMRLSNEYAPEHLILSTGNFEEMADKVVNAGSVFMGKWSCESAGDYASGTNHTLPTHQY 370

Query: 375 TATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNALKEQ 433
               S + L  + +++T Q+LS+ G S++ + +  +A  E L AH +A+ +R+  + ++
Sbjct: 371 ALAYSGVNLDSYCRKITFQQLSENGVSSIGNAVVRMAEDEGLEAHAHAMRIRLKKVDDK 429


>UniRef50_C7NG13 Histidinol dehydrogenase n=2 Tax=Bacteria RepID=C7NG13_KYTSD
          Length = 439

 Score =  414 bits (1065), Expect = e-114,   Method: Compositional matrix adjust.
 Identities = 220/428 (51%), Positives = 286/428 (66%), Gaps = 4/428 (0%)

Query: 6   IIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA 65
           ++DWN+    ++   L RPA +  E +T  V ++LD V+ARG +A+  Y+ +FD      
Sbjct: 3   VLDWNALDDSERTAALERPAQAVGEQVTAAVAEVLDAVRARGADAVVGYTERFDGVGREH 62

Query: 66  LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVA 125
           L +S  EI  A E++ D ++ A+A A   + TFH    L P  V+T PG+RC+++ RPV 
Sbjct: 63  LLLSEAEIDRAVEQVPDAVRAAIAQAAATLRTFHAPGALSPFAVDTAPGMRCERIVRPVR 122

Query: 126 SVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQL-CGVQDV 181
           +VGLY+P GSAPL ST LML  PA +AGC +VV+C+PP     AD  + AA +  G++ +
Sbjct: 123 TVGLYVPAGSAPLPSTALMLGVPAVLAGCPEVVVCTPPTAQGTADPSVVAACVEVGIRRI 182

Query: 182 FNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLV 241
             VGGAQA+ A+AFG   +P+ DKIFGPGN+FVTEAKRQV+    G  ID+PAGPSE LV
Sbjct: 183 AVVGGAQAVGAMAFGAGPIPRCDKIFGPGNSFVTEAKRQVAGMQGGPGIDLPAGPSEQLV 242

Query: 242 IADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQA 301
           IAD+GA P +VA+DLLSQAEHGPDSQV+ ++   D+  +VA  VERQ AELPRA+    A
Sbjct: 243 IADAGANPVWVAADLLSQAEHGPDSQVVCVSDDRDLLEQVAAEVERQAAELPRAQIVAGA 302

Query: 302 LNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDY 361
           L ASRL++  DL Q V +SN Y PEHLI+  R  REL+  IT+AGS+FLGD +PES GDY
Sbjct: 303 LTASRLVLVDDLDQAVAVSNAYAPEHLILAVRAPRELLAGITAAGSIFLGDHTPESLGDY 362

Query: 362 ASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKN 421
            SGTNHVLPT G       + LA FQ  +TVQE S    + L +T  TLA AE L AH  
Sbjct: 363 CSGTNHVLPTSGAARYTGGVNLASFQLSITVQEASPRALAQLGATAVTLARAEGLEAHAR 422

Query: 422 AVTLRVNA 429
           AVT RV+A
Sbjct: 423 AVTRRVDA 430


>UniRef50_D1IQ57 Histidinol dehydrogenase (Fragment) n=1 Tax=Vitis vinifera
           RepID=D1IQ57_VITVI
          Length = 546

 Score =  392 bits (1006), Expect = e-107,   Method: Compositional matrix adjust.
 Identities = 206/410 (50%), Positives = 265/410 (64%), Gaps = 8/410 (1%)

Query: 23  RPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSD 82
           RP I  S SI   V+ I+D+V++RGD A+++Y+ +FDK  +  L  +  E+      L  
Sbjct: 128 RPRIDFS-SIFNVVHPIVDDVRSRGDAAVKDYTTRFDKVELDRLIENVAELP--DPELDA 184

Query: 83  ELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTV 142
            +K+A  VA  NI  FH AQK     VE   GV+C++V R +ASVGLY+PGG+A L ST 
Sbjct: 185 GIKEAFDVAYDNIFAFHAAQKSAEKIVENMKGVKCKRVARSIASVGLYVPGGTAVLPSTA 244

Query: 143 LMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQDVFNVGGAQAIAALAFGTE 198
           LML+ PA IAGCK VVL +PP     I  E+LY A+  GV  +   GGAQAIAA+A+GT 
Sbjct: 245 LMLSVPAQIAGCKTVVLATPPSQDGGICKEVLYCAKKAGVTHILKAGGAQAIAAMAWGTT 304

Query: 199 SVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLS 258
           S PKV+KIFGPGN +VT AK  +       +IDMPAGPSEVLVIAD  A P  +A+DLLS
Sbjct: 305 SCPKVEKIFGPGNQYVTAAKMILQNSEAMVSIDMPAGPSEVLVIADKHANPVHIAADLLS 364

Query: 259 QAEHGPDSQVILLTPAADM-ARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQCV 317
           QAEHGPDSQV+L+     +  R + E + +Q   LPR E A +AL+ S  +  +++ + +
Sbjct: 365 QAEHGPDSQVVLVIAGDGVDLRAIEEEISKQCQSLPRGEFASKALSHSFTVFARNMVEAI 424

Query: 318 EISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTAT 377
             SN Y PEHLII  ++A +  + I +AGSVFLG W+PES GDYASGTNHVLPTYGY   
Sbjct: 425 SFSNLYAPEHLIINVKDAEKWENFIENAGSVFLGQWTPESVGDYASGTNHVLPTYGYARM 484

Query: 378 CSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRV 427
              L L  F K MTVQ L++EG   L   +E +A  E L AHK AVTLR+
Sbjct: 485 YGGLSLDSFLKYMTVQSLTEEGLRKLGPYVEAMAEVEGLEAHKRAVTLRL 534


>UniRef50_UPI00019859BD PREDICTED: hypothetical protein n=1 Tax=Vitis vinifera
           RepID=UPI00019859BD
          Length = 524

 Score =  390 bits (1003), Expect = e-107,   Method: Compositional matrix adjust.
 Identities = 207/417 (49%), Positives = 268/417 (64%), Gaps = 8/417 (1%)

Query: 20  LLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASER 79
           L  RP I  S SI   V+ I+D+V++RGD A+++Y+ +FDK  +  L  +  E+      
Sbjct: 103 LKARPRIDFS-SIFNVVHPIVDDVRSRGDAAVKDYTTRFDKVELDRLIENVAELP--DPE 159

Query: 80  LSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLF 139
           L   +K+A  VA  NI  FH AQK     VE   GV+C++V R +ASVGLY+PGG+A L 
Sbjct: 160 LDAGIKEAFDVAYDNIFAFHAAQKSAEKIVENMKGVKCKRVARSIASVGLYVPGGTAVLP 219

Query: 140 STVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQDVFNVGGAQAIAALAF 195
           ST LML+ PA IAGCK VVL +PP     I  E+LY A+  GV  +   GGAQAIAA+A+
Sbjct: 220 STALMLSVPAQIAGCKTVVLATPPSQDGGICKEVLYCAKKAGVTHILKAGGAQAIAAMAW 279

Query: 196 GTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASD 255
           GT S PKV+KIFGPGN +VT AK  +       +IDMPAGPSEVLVIAD  A P  +A+D
Sbjct: 280 GTTSCPKVEKIFGPGNQYVTAAKMILQNSEAMVSIDMPAGPSEVLVIADKHANPVHIAAD 339

Query: 256 LLSQAEHGPDSQVILLTPAADM-ARRVAEAVERQLAELPRAETARQALNASRLIVTKDLA 314
           LLSQAEHGPDSQV+L+     +  R + E + +Q   LPR E A +AL+ S  +  +++ 
Sbjct: 340 LLSQAEHGPDSQVVLVIAGDGVDLRAIEEEISKQCQSLPRGEFASKALSHSFTVFARNMV 399

Query: 315 QCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGY 374
           + +  SN Y PEHLII  ++A +  + I +AGSVFLG W+PES GDYASGTNHVLPTYGY
Sbjct: 400 EAISFSNLYAPEHLIINVKDAEKWENFIENAGSVFLGQWTPESVGDYASGTNHVLPTYGY 459

Query: 375 TATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNALK 431
                 L L  F K MTVQ L++EG   L   +E +A  E L AHK AVTLR+  ++
Sbjct: 460 ARMYGGLSLDSFLKYMTVQSLTEEGLRKLGPYVEAMAEVEGLEAHKRAVTLRLQDIE 516


>UniRef50_Q87C29 Histidinol dehydrogenase n=66 Tax=cellular organisms
           RepID=HISX_XYLFT
          Length = 431

 Score =  390 bits (1002), Expect = e-107,   Method: Compositional matrix adjust.
 Identities = 217/428 (50%), Positives = 282/428 (65%), Gaps = 5/428 (1%)

Query: 6   IIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA 65
           IIDWN      Q + L RPA + +      V  +++ V+  GD ALR+ +A+FD   +  
Sbjct: 3   IIDWNQLDTAAQAKTLTRPAQTIATQTREAVTALIEQVRRGGDTALRDITARFDGVDLAT 62

Query: 66  LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVA 125
            +V+A E+AAA+  ++ EL+ AM  A   IE FH A       VET PGV C+++ RP+A
Sbjct: 63  FEVTAAELAAAATAVAPELQHAMQTAAARIEAFHRAGMTNDYRVETAPGVVCERLVRPIA 122

Query: 126 SVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADE----ILYAAQLCGVQDV 181
            VGLY+P GSAPLFST LML  PA +AGC++VVLC+PP         +L AA+L GV  V
Sbjct: 123 RVGLYVPAGSAPLFSTALMLGVPARLAGCREVVLCTPPSKDGRANPAVLLAARLTGVTRV 182

Query: 182 FNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLV 241
           F +GGAQAIAA+A+GT SVP  DK+FGPGN+FVTEAK+Q++Q     AIDMPAGPSEVLV
Sbjct: 183 FTLGGAQAIAAMAYGTASVPTCDKVFGPGNSFVTEAKQQLAQ-AGVVAIDMPAGPSEVLV 241

Query: 242 IADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQA 301
           IAD+ A P F+A+DLLSQAEHGPDSQV+LL+ +  +   V  A+  QL +L RAE ARQA
Sbjct: 242 IADAAANPAFIAADLLSQAEHGPDSQVLLLSDSDALMTAVQNALALQLQQLSRAEIARQA 301

Query: 302 LNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDY 361
           L  SR I    L    +ISN+Y PEHLI+  R  R  +  + +AGSVFLGD++PE+ GDY
Sbjct: 302 LAHSRFIKVATLETAFDISNRYAPEHLILALRQPRAWLHRVAAAGSVFLGDYTPEALGDY 361

Query: 362 ASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKN 421
            SGTNHVLPT G     S + ++ FQ  ++VQ  S+ G + +     TLA AE L AH N
Sbjct: 362 CSGTNHVLPTGGAARAYSGVSVSSFQNMISVQAASRSGIAEIGGCALTLARAEGLDAHAN 421

Query: 422 AVTLRVNA 429
           AV LR+ +
Sbjct: 422 AVALRMGS 429


>UniRef50_Q9C5U8 Histidinol dehydrogenase, chloroplastic n=34 Tax=cellular organisms
           RepID=HISX_ARATH
          Length = 466

 Score =  389 bits (1000), Expect = e-107,   Method: Compositional matrix adjust.
 Identities = 209/424 (49%), Positives = 272/424 (64%), Gaps = 8/424 (1%)

Query: 13  TAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEE 72
           ++ Q   L  RP I  S SI  TVN I+D V++ GD A++EY+ +FDK  +  +     E
Sbjct: 41  SSSQVDSLKSRPRIDFS-SIFATVNPIIDAVRSNGDNAVKEYTERFDKVQLNKVVEDMSE 99

Query: 73  IAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIP 132
           ++     L   +K+A  VA  NI  FH AQK     VE   GVRC++V+R + SVGLY+P
Sbjct: 100 LSVP--ELDSNVKEAFDVAYDNIYAFHLAQKSTEKSVENMKGVRCKRVSRSIGSVGLYVP 157

Query: 133 GGSAPLFSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQDVFNVGGAQ 188
           GG+A L ST LMLA PA IAGCK VVL +PP     I  E+LY A+  GV  +   GGAQ
Sbjct: 158 GGTAVLPSTALMLAIPAQIAGCKTVVLATPPSKDGSICKEVLYCAKRAGVTHILKAGGAQ 217

Query: 189 AIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGAT 248
           AIAA+A+GT+S PKV+KIFGPGN +VT AK  +       +IDMPAGPSEVLVIAD  A+
Sbjct: 218 AIAAMAWGTDSCPKVEKIFGPGNQYVTAAKMILQNSEAMVSIDMPAGPSEVLVIADEHAS 277

Query: 249 PDFVASDLLSQAEHGPDSQVILLTPAADM-ARRVAEAVERQLAELPRAETARQALNASRL 307
           P ++A+DLLSQAEHGPDSQV+L+     +    + E + +Q   LPR E A +AL+ S  
Sbjct: 278 PVYIAADLLSQAEHGPDSQVVLVVVGDSVDLNAIEEEIAKQCKSLPRGEFASKALSHSFT 337

Query: 308 IVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNH 367
           +  +D+ + +  SN Y PEHLII  ++A +    I +AGSVF+G W+PES GDYASGTNH
Sbjct: 338 VFARDMIEAISFSNLYAPEHLIINVKDAEKWEGLIENAGSVFIGPWTPESVGDYASGTNH 397

Query: 368 VLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRV 427
           VLPTYGY    S + L  F K MTVQ L++EG   L   + T+A  E L AHK AVTLR+
Sbjct: 398 VLPTYGYARMYSGVSLDSFLKFMTVQSLTEEGLRNLGPYVATMAEIEGLDAHKRAVTLRL 457

Query: 428 NALK 431
             ++
Sbjct: 458 KDIE 461


>UniRef50_C6Y3G2 Histidinol dehydrogenase n=6 Tax=cellular organisms
           RepID=C6Y3G2_PEDHD
          Length = 430

 Score =  387 bits (993), Expect = e-106,   Method: Compositional matrix adjust.
 Identities = 200/429 (46%), Positives = 279/429 (65%), Gaps = 6/429 (1%)

Query: 6   IIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA 65
           I  +   T ++  ++ +R  +    +I   V  I++ VK  GD+AL +Y+  FD+  +  
Sbjct: 3   IYSYKDLTKQEVEEICLR-QLEDDVNIQERVKSIVERVKMEGDKALFDYALSFDQIRLEE 61

Query: 66  LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVA 125
           L +  +EI   +  +  E K A+  A +NI+TFH +Q L    VET PGV C + TR + 
Sbjct: 62  LFIDQQEIMTIAATIPAEAKAAIDTAYQNIKTFHASQLLQEDKVETMPGVTCWRETRAIE 121

Query: 126 SVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADE----ILYAAQLCGVQDV 181
            VGLYIPGG+A L ST LML  PA +AGCK++V+CSPP    +    + Y A L G++ +
Sbjct: 122 RVGLYIPGGTAVLPSTFLMLGIPAVLAGCKEIVVCSPPQKDGKTNCYLAYVATLLGIERI 181

Query: 182 FNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLV 241
           + VGGAQA+AA+A+GT SVPKVDK+FGPGN +VT+AK Q+ Q     AIDMPAGPSEVLV
Sbjct: 182 YLVGGAQAVAAMAYGTASVPKVDKVFGPGNRYVTQAK-QLIQGNTMTAIDMPAGPSEVLV 240

Query: 242 IADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQA 301
           +AD  A P ++ASDLL+QAEHG DSQ IL+  ++ +     E +  QL  LPRA  A +A
Sbjct: 241 LADETAIPSYIASDLLAQAEHGIDSQTILVATSSKIIDETMEQLALQLQVLPRAAFATKA 300

Query: 302 LNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDY 361
           +  S  ++  DL + ++ SN Y PEHLI+ T N   L+  I++AGSVFLG+ +PESAGDY
Sbjct: 301 IENSYSVLVNDLEEGMKFSNVYAPEHLILATDNCERLIPLISNAGSVFLGNLTPESAGDY 360

Query: 362 ASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKN 421
           ASGTNH LPT GY    S + +  F K++T Q ++ +G   + +T+E LAAAE L AHKN
Sbjct: 361 ASGTNHTLPTSGYARAYSGVSMDSFMKKITFQHITTQGLRHIGNTVEVLAAAEGLDAHKN 420

Query: 422 AVTLRVNAL 430
           AV++R+ +L
Sbjct: 421 AVSIRLKSL 429


>UniRef50_B2KCM4 Histidinol dehydrogenase n=1 Tax=Elusimicrobium minutum Pei191
           RepID=B2KCM4_ELUMP
          Length = 429

 Score =  385 bits (990), Expect = e-105,   Method: Compositional matrix adjust.
 Identities = 197/427 (46%), Positives = 279/427 (65%), Gaps = 9/427 (2%)

Query: 6   IIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA 65
           I ++ + T ++ + L  R  +   E + + V +    V  RGD+A++E +A FD  T+++
Sbjct: 3   IYNYATLTKKEIKALSERSYL-MPEKLKQAVWETGLQVMKRGDKAIKELTAAFDGVTLSS 61

Query: 66  LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQ-KLPPVDVETQPGVRCQQVTRPV 124
           LKVS +E   A + +S+ELK A+  A +NI  FH +Q K     +ET  G+ C +  + +
Sbjct: 62  LKVSVKEFKQAEKLVSNELKDAIKTASENIAKFHKSQLKTKEPVIETSKGIECWREFKAL 121

Query: 125 ASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQD 180
            + GLY+PGGSAPLFSTVLMLA PA IAGCKKV +C+PP     IA EIL+AA+  GV +
Sbjct: 122 GTAGLYVPGGSAPLFSTVLMLAVPAKIAGCKKVYICTPPCKNGLIAPEILFAAKTAGVDE 181

Query: 181 VFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVL 240
           V+ +GGAQA+ A+A+GT++VPK DKIFGPGN +VT+AK +VS      AIDMPAGPSEVL
Sbjct: 182 VYKIGGAQAVFAMAYGTQTVPKADKIFGPGNQYVTQAKMEVSSF---TAIDMPAGPSEVL 238

Query: 241 VIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQ 300
           +IA+      + A+D+LSQAEHGPDSQ +L   + +  + +   V+ QL +L R   A +
Sbjct: 239 IIAEESTNASYAAADILSQAEHGPDSQAVLACSSKNKIKEIIAEVDAQLKKLGRKSIAAK 298

Query: 301 ALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGD 360
           AL  S ++ T++  + VE SN Y PEHLI+  ++ ++ + S+ +AGSVF G  + ES GD
Sbjct: 299 ALGKSFIMQTRNTKESVEFSNIYAPEHLILNFKDWKKYLTSVQNAGSVFCGTLATESFGD 358

Query: 361 YASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHK 420
           YASGTNH LPT G+  +   L    F K +T Q +S +G   L  T+E +A AE LTAHK
Sbjct: 359 YASGTNHTLPTSGFAKSFGGLNTQSFGKWITYQTVSAQGLRGLGKTVEIMAEAEGLTAHK 418

Query: 421 NAVTLRV 427
           NAVT+R+
Sbjct: 419 NAVTIRI 425


>UniRef50_B0TY46 Histidinol dehydrogenase n=2 Tax=Francisella philomiragia
           RepID=B0TY46_FRAP2
          Length = 432

 Score =  382 bits (981), Expect = e-104,   Method: Compositional matrix adjust.
 Identities = 191/429 (44%), Positives = 276/429 (64%), Gaps = 4/429 (0%)

Query: 6   IIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA 65
           I +W   +  +Q +LL RP  +   S+   V +IL+ VK  GD+AL E++++FD   +  
Sbjct: 4   IYNWQELSLVKQAELLSRPVSANKASLVAGVRNILNAVKQNGDKALLEFTSRFDGVDLDN 63

Query: 66  LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVA 125
           ++VSA EI  A   +S +  + +  ++  I  +H   K      +T  GV C+++ +P+ 
Sbjct: 64  IEVSAHEIKEAYSLVSQDDIELVKNSIARISNYHEVMKPKTTVCDTNDGVVCKKIYKPIE 123

Query: 126 SVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSP----PPIADEILYAAQLCGVQDV 181
            VGLY+PGGSAPL ST++MLA PA IAGCK++ + +P      I   IL AA +C V  +
Sbjct: 124 KVGLYVPGGSAPLVSTLIMLAAPAQIAGCKEIYVTTPCDKEGNIHPLILIAADICKVSKI 183

Query: 182 FNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLV 241
           + +GGAQAIAALA+GTE+V KV+KI+GPGN++VTEAK+QVS    GAAID+PAGPSEVLV
Sbjct: 184 YKLGGAQAIAALAYGTETVTKVNKIYGPGNSWVTEAKQQVSNDSQGAAIDLPAGPSEVLV 243

Query: 242 IADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQA 301
           +AD  A   FVA+DLL+QAEHG DSQ +L+T +  +A +V + V +Q +   R     +A
Sbjct: 244 VADEVADARFVAADLLAQAEHGTDSQALLITTSQILADKVRDEVSKQTSTAQRKAIIEKA 303

Query: 302 LNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDY 361
           L  S +IV   L+Q + I+N+Y  EHLI+    A   +DSI +AG+VF+G W+ E+ GDY
Sbjct: 304 LENSAIIVVDTLSQAINIANEYASEHLILNIETADNYIDSIENAGAVFVGPWAAEALGDY 363

Query: 362 ASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKN 421
            +G+NHVLPTYGY    S L   DF K +++Q +SK+G   +      LA  E L AH+N
Sbjct: 364 ITGSNHVLPTYGYAKAYSGLATIDFMKAISIQNVSKQGIKNIGQIAMRLADIEGLKAHEN 423

Query: 422 AVTLRVNAL 430
           A+ +R+ +L
Sbjct: 424 AIAIRLESL 432


>UniRef50_D0JBA3 Histidinol dehydrogenase n=2 Tax=Blattabacterium RepID=D0JBA3_BLASB
          Length = 435

 Score =  381 bits (979), Expect = e-104,   Method: Compositional matrix adjust.
 Identities = 184/425 (43%), Positives = 265/425 (62%), Gaps = 17/425 (4%)

Query: 19  QLLMRPAISASESI-----------TRTVNDILDNVKARGDEALREYSAKFDKTTVTALK 67
           Q+ + P     +SI           T  V  I++NVK  GD A++ Y+ K+D   +  ++
Sbjct: 6   QVYIHPTYKTCQSILNRSSEKISHLTDLVLSIINNVKNNGDTAVKTYTRKYDHVDIKHIQ 65

Query: 68  VSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASV 127
           V+ E+   A+ ++S  L++++ +A KNIE FH  Q      +E   GV C + + P+  V
Sbjct: 66  VTEEDFQKANMKVSSHLRKSIEIAYKNIECFHKKQIHEESKIEVSTGVFCWRKSVPIEKV 125

Query: 128 GLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEI----LYAAQLCGVQDVFN 183
           G YIPGGSAPL STVLML  P  +AGCK +VLCSPP    EI    LY A+  G+  ++ 
Sbjct: 126 GFYIPGGSAPLLSTVLMLGVPGKLAGCKNIVLCSPPNKNGEIHPSVLYTAKYVGINQIYK 185

Query: 184 VGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIA 243
           VGG QAIAA+A+GTES+P V KIFGPGN +VT AK+ VSQ+    +IDMPAGPSEV+++A
Sbjct: 186 VGGVQAIAAMAYGTESIPSVYKIFGPGNCYVTIAKQIVSQK-GIVSIDMPAGPSEVVIMA 244

Query: 244 DSGATPDFVASDLLSQAEHGPDSQVILLT-PAADMARRVAEAVERQLAELPRAETARQAL 302
           D  A P +VASDLLSQ+EH P+S ++L+T        +V E +++Q   L + +   +  
Sbjct: 245 DDEANPKYVASDLLSQSEHDPESYILLVTINNKSWIEKVKEELKKQFYHLSKKKILLKIF 304

Query: 303 NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYA 362
             S+++V   L +C+   NQ  PEHLII   N     + + +AGSVFLG++SP S GDYA
Sbjct: 305 RKSKIVVFSSLEECMNFINQVAPEHLIINCNNVSYWSEKVINAGSVFLGNYSPVSIGDYA 364

Query: 363 SGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNA 422
           SGTNHVLPTYGY  + S + +  F K++T Q++SK+G   L+  +  L++ E L AHK +
Sbjct: 365 SGTNHVLPTYGYAKSYSGVSVDSFVKKITFQKISKKGLQNLSECVNVLSSEEGLIAHKKS 424

Query: 423 VTLRV 427
           + +R+
Sbjct: 425 IDIRL 429


>UniRef50_Q2PPB3 Histidine biosynthesis trifunctional protein n=12 Tax=Phaeosphaeria
           RepID=Q2PPB3_PHANO
          Length = 881

 Score =  377 bits (967), Expect = e-103,   Method: Compositional matrix adjust.
 Identities = 201/423 (47%), Positives = 268/423 (63%), Gaps = 8/423 (1%)

Query: 13  TAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEE 72
           T+E     L RP+  ++  I      I+D VK RGD AL EY+ KF+K T     V    
Sbjct: 456 TSETIAAALQRPSQKSTGKIIGICRPIIDAVKTRGDAALLEYTHKFEKATSLTSPVLRAP 515

Query: 73  IAAASERLSDELKQAMAVAVKNIETFHTAQKL-PPVDVETQPGVRCQQVTRPVASVGLYI 131
                 +L+ E  +A+ V+ +NI  FH AQ+   P+ VET PGV C +  RP+  VGLY+
Sbjct: 516 FPPELMQLAPETAKAIDVSFENIRKFHAAQREEKPLVVETMPGVVCSRFARPIERVGLYV 575

Query: 132 PGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQDVFNVGGA 187
           PGG+A L ST LML  PA +AGCKK+VL +PP     +  E++YAA   G + +   GGA
Sbjct: 576 PGGTAVLPSTALMLGVPAMVAGCKKIVLATPPRSNGKVTPEVVYAAHKVGAEMIVLAGGA 635

Query: 188 QAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLD-GAAIDMPAGPSEVLVIADSG 246
           QA+AA+A+GTESV KVDKI GPGN FVT AK  VS   + G +IDMPAGPSE+LVIAD+ 
Sbjct: 636 QAVAAMAYGTESVSKVDKILGPGNQFVTAAKMHVSNDTNAGVSIDMPAGPSELLVIADAS 695

Query: 247 ATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVA--EAVERQLAELPRAETARQALNA 304
           A P FVASDLLSQAEHG DSQVIL+    + A+  A  + + +Q   LPR +  R A+  
Sbjct: 696 ANPAFVASDLLSQAEHGVDSQVILIAVGLNEAQLTAIEDELHKQANALPRVDIVRGAIEH 755

Query: 305 SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASG 364
           S  +    + + +E+SNQY PEHLI+Q  NA ++V+ + +AGSVF+G+W+PES GDY++G
Sbjct: 756 SLTLAASTIEEALELSNQYAPEHLILQVANADKVVELVENAGSVFIGEWTPESVGDYSAG 815

Query: 365 TNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVT 424
            NH LPTYGY    S + LA + K +T   L+KEG   +   +  LA  E L AH+ AV+
Sbjct: 816 VNHSLPTYGYAKQYSGVNLASYVKHITSAHLTKEGLQNVGPAVMELARVEELEAHRRAVS 875

Query: 425 LRV 427
           LR+
Sbjct: 876 LRL 878


>UniRef50_P00815 Histidinol dehydrogenase n=17 Tax=cellular organisms
           RepID=HIS2_YEAST
          Length = 799

 Score =  373 bits (958), Expect = e-102,   Method: Compositional matrix adjust.
 Identities = 197/420 (46%), Positives = 269/420 (64%), Gaps = 12/420 (2%)

Query: 21  LMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERL 80
           L RP    SE I   VN I++NV+ +G+ AL EY+ KFD   ++   ++A       E L
Sbjct: 374 LSRPIQKTSE-IMHLVNPIIENVRDKGNSALLEYTEKFDGVKLSNPVLNAPFPEEYFEGL 432

Query: 81  SDELKQAMAVAVKNIETFHTAQKLPP--VDVETQPGVRCQQVTRPVASVGLYIPGGSAPL 138
           ++E+K+A+ ++++N+  FH AQ LP   ++VETQPGV C +  RP+  VGLYIPGG+A L
Sbjct: 433 TEEMKEALDLSIENVRKFHAAQ-LPTETLEVETQPGVLCSRFPRPIEKVGLYIPGGTAIL 491

Query: 139 FSTVLMLATPASIAGCKKVVLCSPPPIAD-----EILYAAQLCGVQDVFNVGGAQAIAAL 193
            ST LML  PA +A CK++V  SPP  +D     E++Y A+  G   +   GGAQA+AA+
Sbjct: 492 PSTALMLGVPAQVAQCKEIVFASPPRKSDGKVSPEVVYVAEKVGASKIVLAGGAQAVAAM 551

Query: 194 AFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDG-AAIDMPAGPSEVLVIADSGATPDFV 252
           A+GTE++PKVDKI GPGN FVT AK  V        +IDMPAGPSEVLVIAD  A  DFV
Sbjct: 552 AYGTETIPKVDKILGPGNQFVTAAKMYVQNDTQALCSIDMPAGPSEVLVIADEDADVDFV 611

Query: 253 ASDLLSQAEHGPDSQVILL--TPAADMARRVAEAVERQLAELPRAETARQALNASRLIVT 310
           ASDLLSQAEHG DSQVIL+    +    + + +AV  Q  +LPR +  R+ +  S +++ 
Sbjct: 612 ASDLLSQAEHGIDSQVILVGVNLSEKKIQEIQDAVHNQALQLPRVDIVRKCIAHSTIVLC 671

Query: 311 KDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLP 370
               + +E+SNQY PEHLI+Q  NA + V  + +AGSVF+G ++PES GDY+SGTNH LP
Sbjct: 672 DGYEEALEMSNQYAPEHLILQIANANDYVKLVDNAGSVFVGAYTPESCGDYSSGTNHTLP 731

Query: 371 TYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNAL 430
           TYGY    S    A FQK +T Q ++ EG   +   +  +A  E L  H+NAV +R++ L
Sbjct: 732 TYGYARQYSGANTATFQKFITAQNITPEGLENIGRAVMCVAKKEGLDGHRNAVKIRMSKL 791


>UniRef50_Q4P7D9 Putative uncharacterized protein n=3 Tax=Eukaryota
           RepID=Q4P7D9_USTMA
          Length = 896

 Score =  367 bits (942), Expect = e-100,   Method: Compositional matrix adjust.
 Identities = 209/455 (45%), Positives = 277/455 (60%), Gaps = 34/455 (7%)

Query: 9   WNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVT-ALK 67
           +   +A Q+++LL RPA+  +E +      IL +VK RGD AL E + KFDK  +T A++
Sbjct: 443 YEDLSAAQRKELLKRPALR-TEQVMDICRPILRSVKERGDAALLELTEKFDKAKLTNAVR 501

Query: 68  VSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLP---------------------- 105
           +      +   ++  E+K A+ +A  NI  FH AQK                        
Sbjct: 502 LPPFVDDSVMAQIKPEVKVAIDIAYNNIYKFHKAQKTTFGNKSAGATGSGSADGSEGAQD 561

Query: 106 -PVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP- 163
             ++VET PGV C++  RP+ SVGLY+PGGSA L ST LML  PA +A C  VV+ +PP 
Sbjct: 562 GVLEVETMPGVVCRRFARPIESVGLYVPGGSAVLPSTALMLGVPAQVARCPTVVIATPPR 621

Query: 164 ---PIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQ 220
               I+ E+LY A       +   GGAQA+AALA+GTES PKVDKI GPGN FVT AK  
Sbjct: 622 ADGSISPEVLYCASKVNASAILCAGGAQAVAALAYGTESCPKVDKIVGPGNQFVTAAKML 681

Query: 221 VSQRLDG-AAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPA---AD 276
           V    D   +IDMPAGPSEVLVIAD  A   FVASDLLSQAEHGPDSQV+L+  A   ++
Sbjct: 682 VQNETDAIVSIDMPAGPSEVLVIADREADAAFVASDLLSQAEHGPDSQVVLVGIALSSSE 741

Query: 277 MARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNAR 336
           +A   AE V+RQ   LPR +  RQA++ S  ++  D A  +E SN Y PEHLI+QTR+A 
Sbjct: 742 LAAIEAE-VDRQARALPRVDVVRQAIDKSVTVIVPDRATAMEWSNAYAPEHLILQTRDAE 800

Query: 337 ELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELS 396
            LV+ + +AGS+F+G WSPES GDY SGTNH LPT  Y  + S + +A F+K +T Q L+
Sbjct: 801 SLVECVQNAGSIFVGPWSPESCGDYMSGTNHSLPTAAYAKSYSGVNVATFEKCITSQSLT 860

Query: 397 KEGFSALASTIETLAAAERLTAHKNAVTLRVNALK 431
           ++G    A  +  LA  E L AH  AV +R++ ++
Sbjct: 861 QQGLKGFAQNVIDLAMCEGLQAHAMAVKIRLDRIQ 895


>UniRef50_Q9P777 Histidinol dehydrogenase n=71 Tax=cellular organisms
           RepID=HISX_SCHPO
          Length = 439

 Score =  361 bits (926), Expect = 3e-98,   Method: Compositional matrix adjust.
 Identities = 198/426 (46%), Positives = 273/426 (64%), Gaps = 15/426 (3%)

Query: 11  SCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA--LKV 68
           + TAE++ +LL RP I  ++ I   V  I+++VK+RG+ +L +Y++KF+K  + +  LK 
Sbjct: 15  ALTAEERTRLLARP-IQNTQKIRTIVQPIIEDVKSRGEASLIDYASKFEKVQLKSAVLKA 73

Query: 69  SAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVG 128
             ++      ++S  +K+ + +A  NI  FH++Q  P + V+T  GV CQ+++RP+  VG
Sbjct: 74  PFDDDLM---KISPMIKEDIDIAFNNIFAFHSSQLRPTIAVQTMRGVVCQRMSRPINRVG 130

Query: 129 LYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSP----PPIADEILYAAQLCGVQDVFNV 184
           LYIPGG+A L ST LML  PA +AGC  VV+ +P      +A EI+Y A   G + +   
Sbjct: 131 LYIPGGTAVLPSTALMLGVPAKVAGCPHVVISTPVRKDGTVAPEIVYIANKIGAEAIILA 190

Query: 185 GGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGA--AIDMPAGPSEVLVI 242
           GGAQAIAA+A+G   VPKV+KIFGPGN FVT AK  V Q   GA  AID+PAGPSEVLVI
Sbjct: 191 GGAQAIAAMAYGISGVPKVNKIFGPGNQFVTAAKMHV-QNDYGALVAIDLPAGPSEVLVI 249

Query: 243 ADSGATPDFVASDLLSQAEHGPDSQVILLTPA--ADMARRVAEAVERQLAELPRAETARQ 300
           AD    P+ VA DLLSQAEHG DSQ+ILLT +   +M  R+ +A+      L R+   + 
Sbjct: 250 ADETCNPESVALDLLSQAEHGLDSQIILLTVSLSPEMFDRIQKAINDHALRLSRSYIIKH 309

Query: 301 ALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGD 360
           A+  S ++   ++ Q  E SN YGPEHL++  +NA   +  I +AGSVF+G WSP S GD
Sbjct: 310 AIKKSVIVQVDNVDQAFEWSNLYGPEHLVLHLKNASSYIPKIDNAGSVFVGPWSPVSMGD 369

Query: 361 YASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHK 420
           YASGTNH LPTYGY ++ S +    F K +T QEL++EG   L  T+  LA  E LTAH 
Sbjct: 370 YASGTNHTLPTYGYASSYSGVSTDSFLKYITTQELTEEGIQRLGPTVIRLAELEGLTAHA 429

Query: 421 NAVTLR 426
           +AV +R
Sbjct: 430 DAVRVR 435


>UniRef50_D1CF70 Histidinol dehydrogenase n=1 Tax=Thermobaculum terrenum ATCC
           BAA-798 RepID=D1CF70_THET1
          Length = 433

 Score =  358 bits (919), Expect = 2e-97,   Method: Compositional matrix adjust.
 Identities = 186/417 (44%), Positives = 270/417 (64%), Gaps = 9/417 (2%)

Query: 15  EQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIA 74
           E++R+L  R   + S  +T  V  I+++V+ +GDE++REY+ +FD   + +L+V   EI 
Sbjct: 18  EERRRLTHRSG-AISMDVTSVVRQIVEDVRQKGDESVREYTERFDGVKLDSLEVPRVEIE 76

Query: 75  AASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGG 134
            A +R+   L +AM++A  NI  FH+AQ  P   VET PGV+  +V RP+  VG+Y+PGG
Sbjct: 77  TALDRIDQHLAEAMSIAASNIRAFHSAQIHPEPVVETSPGVKVWRVWRPIERVGVYVPGG 136

Query: 135 SAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQDVFNVGGAQAI 190
            A   STVLM A PAS+AGC ++VLC+PP     + +  L AA L GV  VF++GGAQAI
Sbjct: 137 GARYPSTVLMHAVPASVAGCSEIVLCTPPGPDGKVPEATLAAAALSGVTRVFSIGGAQAI 196

Query: 191 AALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPD 250
           AA+A+GT+++P V KIFGPGN +VT AK  V   +D   ID PAGPSE+++IAD  A P 
Sbjct: 197 AAMAYGTQTIPPVQKIFGPGNVYVTAAKMLVFGDVD---IDKPAGPSELVIIADDTADPR 253

Query: 251 FVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLI-V 309
             A+DL++Q+EH PD+  +L+T +  +A  V   + RQL +LP  +    +  ++  I +
Sbjct: 254 ETAADLIAQSEHAPDNASVLVTTSESLAEAVLSELTRQLEDLPNRDRVISSFRSNGFILL 313

Query: 310 TKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVL 369
            +DLAQ V   N+Y PEHL I T + RE+++ I +AGS+FLG +SP  AGDYA G+NHVL
Sbjct: 314 VEDLAQAVGFVNEYAPEHLQIVTVSPREILEGINNAGSIFLGRYSPVPAGDYAVGSNHVL 373

Query: 370 PTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
           PT G   T   L   +F K + VQEL++EG  ++++ +  +A AE L  H  A+ +R
Sbjct: 374 PTSGSARTFGPLSTEEFGKWVQVQELTQEGLRSISNAVTAMARAENLEGHARAIEVR 430


>UniRef50_Q5ZW87 Histidinol dehydrogenase n=6 Tax=Legionella RepID=HISX_LEGPH
          Length = 431

 Score =  357 bits (915), Expect = 6e-97,   Method: Compositional matrix adjust.
 Identities = 195/435 (44%), Positives = 281/435 (64%), Gaps = 13/435 (2%)

Query: 5   TIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVT 64
           TI +W   +   ++  L RP    S +I   V +I++ V+  GD+AL + + +FD+  + 
Sbjct: 3   TIKNWQLLSENDKKLCLSRP--RQSSAIKENVLEIINQVQLSGDKALYDLTKQFDRVNLQ 60

Query: 65  ALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVE--TQPGVRCQQVTR 122
            L+V  E+I  A+  +      A+  A+  I ++H  Q L P + E  T  G+  + V R
Sbjct: 61  YLQVPQEKIEQAN--IPKNALNAITQAIGTISSYH--QSLLPENTEISTASGITIRNVYR 116

Query: 123 PVASVGLYIPGGS-APLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCG 177
           P+  VGLY+PGG+  PL S++LM A PA +AGC   VLC+PP     I + IL AA+LCG
Sbjct: 117 PIQKVGLYVPGGNKTPLVSSLLMQAIPAKVAGCPIKVLCTPPDAEGEINEHILVAARLCG 176

Query: 178 VQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPS 237
           +  ++ +GGAQAIAA+A+GTESV KVDKIFGPGN++VT+AK  V+   DGAAIDMPAGPS
Sbjct: 177 IDTIYAIGGAQAIAAMAYGTESVIKVDKIFGPGNSYVTQAKTLVAIDADGAAIDMPAGPS 236

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAET 297
           EV+++AD+ A P+F+A+DLL+QAEHGPDSQVIL+    ++A +V + +E Q++ L R E 
Sbjct: 237 EVMILADTEANPEFIAADLLAQAEHGPDSQVILICDECELANQVNQQLEIQMSYLSRIEF 296

Query: 298 ARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPES 357
            +++L  SR+I+  + ++ ++I N Y PEHLII  +N    V+ I +AG+VFLG W+ E+
Sbjct: 297 IKRSLANSRIIICSNQSEQLDIINSYAPEHLIINRKNPEPWVEKIVAAGTVFLGSWAAET 356

Query: 358 AGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLT 417
            GDY +G+NHVLPT G+    S L   DF  R TVQ +++E    L     TLA  E L 
Sbjct: 357 MGDYVTGSNHVLPTSGFARNHSGLSTLDFMTRFTVQAINQEAIRNLGPAAMTLAELEGLD 416

Query: 418 AHKNAVTLRVNALKE 432
           AH NAV +R+N L +
Sbjct: 417 AHANAVQIRLNTLGD 431


>UniRef50_A9NV24 Histidinol dehydrogenase n=2 Tax=Spermatophyta RepID=A9NV24_PICSI
          Length = 491

 Score =  354 bits (909), Expect = 3e-96,   Method: Compositional matrix adjust.
 Identities = 197/431 (45%), Positives = 264/431 (61%), Gaps = 15/431 (3%)

Query: 16  QQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAA 75
           Q   L  RP I  S S+   V  I+++V+ RGD A+ +Y+ KFD   +  +     ++  
Sbjct: 62  QIDHLKARPRIDFS-SMFGVVGPIIEDVRKRGDVAVIDYTTKFDGVNLDKVVECVADLP- 119

Query: 76  ASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQP-------GVRCQQVTRPVASVG 128
              +L   ++ A  VA  NI  FH AQ+ P   VE          GV C++V R + SVG
Sbjct: 120 -DPKLDSAVQAAFDVAYDNIRAFHAAQRNPERVVENMKVGSVLGRGVMCKRVARSIDSVG 178

Query: 129 LYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQDVFNV 184
           LY+PGG+A L ST LMLA PA +AGC+ ++L SPP     I  E+LY A+  GV  +   
Sbjct: 179 LYVPGGTAVLPSTALMLAVPAQLAGCRIIILASPPRPDGSICKEVLYCAKKAGVTHILKA 238

Query: 185 GGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIAD 244
           GGAQAI+A+A+GT S PKV+KI GPGN +VT AK  +       +IDMPAGPSEVLVIAD
Sbjct: 239 GGAQAISAMAWGTTSCPKVEKILGPGNQYVTAAKMILQNSEAMISIDMPAGPSEVLVIAD 298

Query: 245 SGATPDFVASDLLSQAEHGPDSQVILLTPAADM-ARRVAEAVERQLAELPRAETARQALN 303
             A P ++A+DLLSQAEHGPDSQV+L+     +    +   +E+Q   LPR + A +AL 
Sbjct: 299 KHANPVYIAADLLSQAEHGPDSQVVLVLVGEGVNLDEIEMELEKQCKSLPRGQFAAKALT 358

Query: 304 ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYAS 363
            S  ++ ++ A+ +  SN Y PEHLII   +A + VD I +AGSVFLG WSPES GDYAS
Sbjct: 359 HSFTVLARNKAEAISFSNLYAPEHLIINVEDADQWVDYIENAGSVFLGRWSPESIGDYAS 418

Query: 364 GTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAV 423
           GTNHVLPTYGY      + L  F K +TVQ L++EG  +L   +  +A  E L AHK AV
Sbjct: 419 GTNHVLPTYGYARMYGGVSLDSFMKYITVQSLTEEGLKSLGPHVVKMAEVEGLEAHKRAV 478

Query: 424 TLRVNALKEQA 434
           TLR+  ++ ++
Sbjct: 479 TLRLQDIETRS 489


>UniRef50_B4W8G9 Histidinol dehydrogenase n=2 Tax=Caulobacteraceae
           RepID=B4W8G9_9CAUL
          Length = 435

 Score =  342 bits (878), Expect = 1e-92,   Method: Compositional matrix adjust.
 Identities = 195/432 (45%), Positives = 263/432 (60%), Gaps = 13/432 (3%)

Query: 6   IIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA 65
           +IDW+S  A  +R  L RPA   +  +T  V  ILD+V+ARG  A+ ++  K DK     
Sbjct: 3   LIDWSSLDAAGKRAALARPAQRTAGDVTDVVRTILDDVRARGGAAVTDWCLKLDKAPPRR 62

Query: 66  LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVD---VETQPGVRCQQVTR 122
           + ++ E +A A   L     +A+ +A +N+  FH A K  P D   +ET PGVR +   R
Sbjct: 63  IAITPEAVAEARNALPPGDVRALRMAAENVRVFHQATK--PEDTPFIETTPGVRSKLAWR 120

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGV 178
           P+AS GLYIPGG+APLFS++LMLA PA +AG  + V  +PP     I   ++ AA    +
Sbjct: 121 PIASAGLYIPGGTAPLFSSLLMLAIPAGVAGVGERVAVTPPDKNGGIHPAMILAAAEAEL 180

Query: 179 QDVFNVGGAQAIAALAFGTE----SVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPA 234
             ++ +GGAQAIAAL FG E     +P  DK+FGPGNA+V EAK+Q S    G A+DMPA
Sbjct: 181 DAIWLMGGAQAIAALTFGVELEDGIIPACDKLFGPGNAYVAEAKKQASALPGGPAVDMPA 240

Query: 235 GPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPR 294
           GPSE++VI D  A P+  A+DLLSQAEH  D+QVIL++ +      +   VE Q+A LPR
Sbjct: 241 GPSELMVIVDRDAAPEIAAADLLSQAEHDADAQVILVSTSRATIDYILSEVEVQVAALPR 300

Query: 295 AETARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWS 354
              AR +LN +R I+ +DL    E++N YGPEHL IQ  +   LVDSI +AG+VF+G ++
Sbjct: 301 EAIARASLNEARAILVRDLDAAAEVANLYGPEHLAIQIDDPEPLVDSIKAAGAVFVGRFA 360

Query: 355 PESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAE 414
            E+ GDYA+G +HVLPT G   T   +  A F   M+VQ +S+ G  ALA     LA  E
Sbjct: 361 AETLGDYAAGPSHVLPTDGGARTLGGVTTASFMTTMSVQLVSEAGARALAPIAARLARME 420

Query: 415 RLTAHKNAVTLR 426
            L AH  A  LR
Sbjct: 421 GLEAHARAADLR 432


>UniRef50_Q8R882 Histidinol dehydrogenase n=7 Tax=Clostridia RepID=HISX_THETN
          Length = 430

 Score =  342 bits (878), Expect = 1e-92,   Method: Compositional matrix adjust.
 Identities = 180/404 (44%), Positives = 262/404 (64%), Gaps = 10/404 (2%)

Query: 29  SESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA--LKVSAEEIAAASERLSDELKQ 86
           ++ I + V DI++NV+ R D+AL EY+  +D   + +  +KV  EEI  A E + ++  +
Sbjct: 27  NKEIAKRVEDIIENVRERKDKALFEYTYMYDGINLNSETVKVKEEEIKRAYEEVKEDFLK 86

Query: 87  AMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLA 146
           A+  A+KNI  FH  QK     ++ + G+   QV RP++SVG+Y+PGG+A   S+VLM  
Sbjct: 87  ALDKAIKNITEFHEKQK-EKTWMDFKEGIVYGQVLRPLSSVGIYVPGGTASYPSSVLMNG 145

Query: 147 TPASIAGCKKVVLCSP---PPIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKV 203
            PA +AG +++V+ SP     I+  +L AA   G+++++ +GGAQA+AALAFGTES+PKV
Sbjct: 146 IPAKVAGVERIVMVSPAGKKGISPYVLVAADKIGIKEIYKIGGAQAVAALAFGTESIPKV 205

Query: 204 DKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHG 263
           DKI GPGN +V  AKR +   +D   IDM AGPSE+LVIAD  A+P +VA+DLLSQAEH 
Sbjct: 206 DKIVGPGNIYVAMAKRALYGYVD---IDMVAGPSEILVIADESASPKYVAADLLSQAEHD 262

Query: 264 PDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVEISNQ 322
             +  IL+T + ++A +V + +ERQ+  L R E   ++L N   +IV  +L + + I+N+
Sbjct: 263 VMASSILVTTSKELAEKVKKEIERQMEYLERKEIIAESLKNFGAIIVIDNLKEAIGIANE 322

Query: 323 YGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLG 382
             PEHL +   N  E++  I +AG+VFLG++SPE  GDY +G NHVLPT G     S L 
Sbjct: 323 IAPEHLELVIENPFEILGEIKNAGAVFLGEFSPEPLGDYLAGPNHVLPTSGTARFFSPLS 382

Query: 383 LADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
           + DF K+M V   SKE  S++   + TLA AE LTAH N+V +R
Sbjct: 383 VRDFVKKMNVLYYSKEALSSVKDDVITLAEAEELTAHANSVKVR 426


>UniRef50_O26327 Histidinol dehydrogenase n=6 Tax=Euryarchaeota RepID=HISX_METTH
          Length = 426

 Score =  340 bits (873), Expect = 5e-92,   Method: Compositional matrix adjust.
 Identities = 181/397 (45%), Positives = 247/397 (62%), Gaps = 8/397 (2%)

Query: 36  VNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAMAVAVKNI 95
           V DI+  V+  GD+ALRE + +FD  TV   +VS EEI  A + L   +K+A+  A  NI
Sbjct: 31  VADIISMVRDGGDDALRELTGRFDGVTVENFRVSREEIEEAHKNLEPGVKEALREAASNI 90

Query: 96  ETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCK 155
           E FH  Q       E +PGV   Q+ RP+ SVG YIPGG A   ST+LM   PA IAG +
Sbjct: 91  EEFHRMQMPSGWMSEVRPGVMAGQLVRPIDSVGCYIPGGRAVYPSTILMTVIPARIAGVE 150

Query: 156 KVVLCSPP----PIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGN 211
           ++V C+PP     + D +L AA + G  +++ VGGAQA+AA+A+GTE++  VDKI GPGN
Sbjct: 151 RIVCCTPPAQDGSVPDAVLVAADMAGASEIYRVGGAQAVAAMAYGTETIRPVDKIVGPGN 210

Query: 212 AFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILL 271
            FVT AK+ V   +D   ID PAGPSEVL+IAD  A+P+++A ++L+QAEH P +  +L+
Sbjct: 211 IFVTAAKKLVYGEVD---IDFPAGPSEVLIIADETASPEYIALEILAQAEHDPQAASVLV 267

Query: 272 TPAADMARRVAEAVERQLAELPRAETARQALNASRLIV-TKDLAQCVEISNQYGPEHLII 330
           T + D+A  V E V   +  + RA   R++L    +IV T D+ + V+ SN Y PEHL+I
Sbjct: 268 TDSRDLALEVKEMVHENIKYMERANIIRESLERYGMIVLTADIDEAVDFSNAYAPEHLVI 327

Query: 331 QTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRM 390
            T +  E ++ I +AGS+FLG+ SP +AGDY SGTNHVLPT G     S L    F K+ 
Sbjct: 328 MTDSPEETLEGIRNAGSIFLGELSPVAAGDYGSGTNHVLPTSGCARMYSGLSTESFIKKP 387

Query: 391 TVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRV 427
           TVQ ++KEG   L  T+  LA  E L AH  +   R+
Sbjct: 388 TVQRITKEGLRNLQGTVLKLAEYEGLHAHAESFRRRL 424


>UniRef50_Q465R4 Histidinol dehydrogenase n=7 Tax=Euryarchaeota RepID=HISX_METBF
          Length = 433

 Score =  332 bits (852), Expect = 1e-89,   Method: Compositional matrix adjust.
 Identities = 189/432 (43%), Positives = 257/432 (59%), Gaps = 15/432 (3%)

Query: 1   MSFNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDK 60
           M F  + D +   AE Q+ LL R   S  E + +TV+ +L +V+ +GD ALREY+AKFDK
Sbjct: 4   MLFKKLSDVSE--AEMQK-LLSRG--SGLEDVAKTVSTVLSDVRTKGDSALREYTAKFDK 58

Query: 61  TTVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVD--VETQPGVRCQ 118
             +    VS EE   A   +S EL   +  A  NI  FH AQ LP     +E +PG+   
Sbjct: 59  VELANFGVSEEEFQQALSGISPELLDHLKSAAANIRAFHEAQ-LPKATWFMELKPGIVLG 117

Query: 119 QVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQ 174
           Q   P+ SVG Y PGG A   STVLM   PA +AG ++V++C+PP     +    L AA+
Sbjct: 118 QKATPLESVGAYAPGGRASYPSTVLMTVIPARVAGVEQVIVCTPPRPDGSVHPLTLAAAK 177

Query: 175 LCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPA 234
           + G   VF +GG QAI ++A+GTE+VPKVDKI GPGN FVT AK Q+    D A ID PA
Sbjct: 178 VAGADKVFKLGGVQAIGSMAYGTETVPKVDKIVGPGNVFVTAAKMQIR---DVAEIDFPA 234

Query: 235 GPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPR 294
           GPSEVL+IAD  A    VASD+L+Q+EH P+S  IL+T +  +A  V   V  Q  +  R
Sbjct: 235 GPSEVLIIADESADAVMVASDILAQSEHDPNSVSILVTGSDTLAEAVKREVLVQAEQAAR 294

Query: 295 AETARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWS 354
           +   + +L  + +++   L QC+  SN++ PEHL I   +   ++D I +AGS+F+G++S
Sbjct: 295 SSIIKSSLENAAILIADSLEQCIGFSNKFAPEHLEIMVADPDFVLDRIKNAGSIFIGNYS 354

Query: 355 PESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAE 414
           P   GDYASGTNHVLPT GY    S L +  F K  ++Q +SK G  +L  T+  LA  E
Sbjct: 355 PVPVGDYASGTNHVLPTSGYARVYSGLNINHFIKYSSIQRISKSGLESLKETVIALAEEE 414

Query: 415 RLTAHKNAVTLR 426
            L AH +A+  R
Sbjct: 415 GLQAHADAIRTR 426


>UniRef50_A1ZJE8 Histidinol dehydrogenase n=1 Tax=Microscilla marina ATCC 23134
           RepID=A1ZJE8_9SPHI
          Length = 429

 Score =  330 bits (845), Expect = 8e-89,   Method: Compositional matrix adjust.
 Identities = 170/429 (39%), Positives = 262/429 (61%), Gaps = 17/429 (3%)

Query: 8   DWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALK 67
           DW+     Q+R           E++ + V  IL  V+  GD+ALR +  K+D+  +   +
Sbjct: 11  DWSKL---QERTF------ETYEALEKAVRPILRRVQREGDKALRSFVFKYDRVRIKRFQ 61

Query: 68  VSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASV 127
           ++ EE+A AS  +SDELK+A+ VA  NI TFH  Q      +ET  GV   Q   P+A V
Sbjct: 62  LTPEELAEASNHVSDELKEAINVAKYNIATFHLTQTKAVKKIETTEGVFSWQKNVPIAKV 121

Query: 128 GLYIPG-GSAPLFSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQDVF 182
           GLY+P  G APL+S +LM+   A+IAGCK+++LCS       I   ILY A L  ++ V+
Sbjct: 122 GLYVPSTGDAPLYSHILMMGILANIAGCKEIILCSAANHEGRIHPIILYTAHLLNIKKVY 181

Query: 183 NVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVI 242
            VGG QAIAA+A+GTE++PKVDKIFGP N +V+ AK+ VS+  +  AIDMP GPSE+  +
Sbjct: 182 RVGGVQAIAAMAYGTETIPKVDKIFGPSNEYVSTAKQLVSK--NDVAIDMPVGPSELCYV 239

Query: 243 ADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELP-RAETARQA 301
           AD    P + A+D+L+ AE    +Q+++LT A ++A ++   V++QL ELP + E A++ 
Sbjct: 240 ADQSTNPVYAAADILAHAEQSSHNQLVVLTNAEEVADKIQAEVDKQLNELPLKKEVAKEV 299

Query: 302 LNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDY 361
              +++IV K   + +  +N+Y PE+L++   NA  + D IT+A S+ LG  +P + G Y
Sbjct: 300 FKNAKIIVFKSNVESIAFANEYAPENLVLAIDNAEAVGDRITNASSIHLGHLTPPAVGYY 359

Query: 362 ASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKN 421
           A+G NH+LP+ G+  + S L +  F K++  Q+++  G   + ST+ T++ AE L   KN
Sbjct: 360 AAGPNHILPSNGFARSYSGLSVDSFVKKINFQQVTPLGLQNVGSTVATMSEAEELLGRKN 419

Query: 422 AVTLRVNAL 430
           ++  R+  L
Sbjct: 420 SIIKRLELL 428


>UniRef50_Q2HFX2 Putative uncharacterized protein n=1 Tax=Chaetomium globosum
           RepID=Q2HFX2_CHAGB
          Length = 817

 Score =  330 bits (845), Expect = 9e-89,   Method: Compositional matrix adjust.
 Identities = 190/418 (45%), Positives = 247/418 (59%), Gaps = 38/418 (9%)

Query: 24  PAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASE----- 78
           P  +A E IT  V D+    +   DEALR  S K   T +  +    ++ +   +     
Sbjct: 419 PKEAAPERITMKVFDMATASRKELDEALRRPSQKSSDTIMKIITPIIDDTSPVLKAPFPE 478

Query: 79  ---RLSDELKQAMAVAVKNIETFHTAQKL-PPVDVETQPGVRCQQVTRPVASVGLYIPGG 134
              +L  E  +AM V+ +NI  FH AQK   P+ VET PGV C + +RP  +VGLY+PGG
Sbjct: 479 SLMQLPTETIKAMDVSFENIRKFHAAQKEEKPLQVETIPGVVCSRFSRPPEAVGLYVPGG 538

Query: 135 SAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVFNVGGAQAIAALA 194
           +A L ST  ML  PA +A CKK+VL SPP                       + A+AA+A
Sbjct: 539 TAVLPSTAFMLGVPAMVAACKKIVLASPP----------------------RSDAVAAMA 576

Query: 195 FGTESVPKVDKIFGPGNAFVTEAKRQVSQRLD-GAAIDMPAGPSEVLVIADSGATPDFVA 253
           +GTESV KVDKI GPGN FVT AK  VS   + G  IDMPAGPSEVLVIAD  A P FVA
Sbjct: 577 YGTESVSKVDKILGPGNQFVTAAKMFVSNDTNAGVGIDMPAGPSEVLVIADKDANPAFVA 636

Query: 254 SDLLSQAEHGPDSQVIL----LTPAADMARRVAEAVERQLAELPRAETARQALNASRLIV 309
           SDLLSQAEHG DSQVIL    LT A  +A  + + V +Q   LPR +  R ++  S  + 
Sbjct: 637 SDLLSQAEHGVDSQVILIAIDLTDAQLLA--IEDEVHKQAMALPRVDIVRGSIAHSLTVR 694

Query: 310 TKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVL 369
            K + + +EISNQY PEHLI+Q ++A  +VD + +AGSVF+G+W+PES GDY++G NH L
Sbjct: 695 VKTVDEAMEISNQYAPEHLILQIKDAESVVDKVMNAGSVFIGEWTPESVGDYSAGVNHSL 754

Query: 370 PTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRV 427
           PTYGY    S + LA F K +T   L+ EG   +   +  LA  E L AH+ AV++R+
Sbjct: 755 PTYGYAKQYSGVNLASFVKHITSSNLTAEGLRNVGEAVMQLAKVEELEAHRRAVSIRL 812


>UniRef50_A8RCE7 Putative uncharacterized protein n=1 Tax=Eubacterium dolichum DSM
           3991 RepID=A8RCE7_9FIRM
          Length = 427

 Score =  325 bits (832), Expect = 3e-87,   Method: Compositional matrix adjust.
 Identities = 182/416 (43%), Positives = 258/416 (62%), Gaps = 14/416 (3%)

Query: 16  QQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAA 75
           ++R+++M PA+     I R V+ IL++V+  GDEA+  Y+ +FD   +  L+VS+EE+ A
Sbjct: 18  EERRVVMNPAL-----IGR-VSAILEDVRMHGDEAVLRYTKQFDGMELNKLRVSSEELNA 71

Query: 76  ASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGS 135
            ++  + E +++M  A +NI  +H AQ      +E + G+   Q   P+ SVG+Y+PGGS
Sbjct: 72  QADLCTPEFRRSMQQAKENILFYHQAQISKGYRLEKEMGIYLGQRVLPLDSVGIYVPGGS 131

Query: 136 APLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQDVFNVGGAQAIA 191
           A   S+VLM A PA +AG K++V+ +PP     I   I  AA+L G+ +V+ VGGAQ IA
Sbjct: 132 AQYPSSVLMNALPARLAGVKRIVMLTPPSKEGSIHTNIALAAKLVGIDEVYKVGGAQGIA 191

Query: 192 ALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDF 251
           ALA+GT+S+ KVDKI GPGN +V  AK+ V   +D   IDM AGPSE+LVI D GA P +
Sbjct: 192 ALAYGTQSIAKVDKIVGPGNVYVACAKKLVFGDVD---IDMIAGPSEILVIGDEGANPKW 248

Query: 252 VASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVT 310
           +A+DLLSQAEH P +  +LL  + +M   V + +++Q   LPR +   ++L N    +V 
Sbjct: 249 IAADLLSQAEHDPQASAVLLAVSQNMVDAVKQELQKQTRCLPRQKIIHESLENYGLALVC 308

Query: 311 KDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLP 370
           + L QCV+ISNQ  PEHL +      EL+  +  AGSVFLG  + ES GDY  GTNHVLP
Sbjct: 309 ESLQQCVDISNQIAPEHLELMVDKPEELLPLVRHAGSVFLGYATCESVGDYFGGTNHVLP 368

Query: 371 TYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
           T G     + LG+  F K+ +    S E   A   +I TLA AE+L AH NAV +R
Sbjct: 369 TGGTARFFNPLGVDSFVKKSSYLHYSIEALQAYGDSIITLAEAEQLQAHANAVKVR 424


>UniRef50_Q58851 Histidinol dehydrogenase n=16 Tax=Euryarchaeota RepID=HISX_METJA
          Length = 429

 Score =  323 bits (827), Expect = 9e-87,   Method: Compositional matrix adjust.
 Identities = 174/404 (43%), Positives = 244/404 (60%), Gaps = 11/404 (2%)

Query: 30  ESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAMA 89
           E I  TV +IL +VK +GDEAL+ Y+ KFD   +   KV+ EEI  A   +  ++ +A+ 
Sbjct: 30  EEILPTVMEILKDVKEKGDEALKYYTKKFDGVEIEDFKVTDEEIEEAYNSVDYKVVEAIE 89

Query: 90  VAVKNIETFHTAQ--KLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLAT 147
            A +NI  FH  Q  ++  ++VE   G+   QV R +  VG Y+PGG A   STVLM   
Sbjct: 90  RAKENIYFFHKKQMEQIKDLNVENN-GIILGQVVRAIEKVGCYVPGGRAFYPSTVLMTTI 148

Query: 148 PASIAGCKKVVLCSPPPIADE----ILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKV 203
           PA +AGC+++ + SPP    +     L A  + GV  ++ VGG QAI ALA+GTE++PKV
Sbjct: 149 PAKVAGCEEIYITSPPTKDGKGNPATLIAGDIVGVSAIYKVGGVQAIGALAYGTETIPKV 208

Query: 204 DKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHG 263
           D I GPGN +VT AK+ V   +   AID  AGPSEVL+IAD  A  +FVA D ++QAEH 
Sbjct: 209 DIIVGPGNIYVTTAKKMVYGEV---AIDFLAGPSEVLIIADETANAEFVALDFIAQAEHD 265

Query: 264 PDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQCVEISNQY 323
           P++  ++ T +   A  +   +  ++ +  R E   +AL  S +++  DL +C+E SN+Y
Sbjct: 266 PNASCVITTTSEKKAEEIKNKIFEEIEKAERKEIILKALENSAILIG-DLEECIEFSNKY 324

Query: 324 GPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGL 383
            PEHL I T+N  E+++ I  AGSVFLG++SP   GDYASGTNHVLPT  +    S L +
Sbjct: 325 APEHLEILTKNPEEVLNKIKHAGSVFLGEYSPVPVGDYASGTNHVLPTSQFARMSSGLNV 384

Query: 384 ADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRV 427
             F K++T Q+L KE    +A  + TLA AE L  H  AV  R+
Sbjct: 385 ETFLKKITYQKLDKESLKNIADIVITLAEAEGLFGHAEAVRRRL 428


>UniRef50_Q2NHT1 HisD n=1 Tax=Methanosphaera stadtmanae DSM 3091 RepID=Q2NHT1_METST
          Length = 407

 Score =  321 bits (822), Expect = 3e-86,   Method: Compositional matrix adjust.
 Identities = 164/403 (40%), Positives = 251/403 (62%), Gaps = 8/403 (1%)

Query: 29  SESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAM 88
           S  + + V +I+ NV    D+AL +Y+ KFDK  ++  KV  E I  + E +S +L++A+
Sbjct: 3   SSDVIQPVQEIIANVCENKDKALHDYTLKFDKADISDFKVPVETIKQSVENISPKLRKAL 62

Query: 89  AVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATP 148
             A +NI  FH AQ      +  + GV+  Q+ RP++ VG YIPGG A   S++LM   P
Sbjct: 63  EDAAENISKFHKAQIPSDWTMTVKDGVKAGQIIRPLSRVGCYIPGGRAAYPSSILMTVIP 122

Query: 149 ASIAGCKKVVLCSPPP----IADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVD 204
           A IAG ++++ C+PP     ++DEIL AA + GV D++ VGGAQAIAA+A+ T+++P VD
Sbjct: 123 AKIAGVEEIICCTPPDKDGCVSDEILAAAYIAGVTDIYMVGGAQAIAAMAYSTQTIPSVD 182

Query: 205 KIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGP 264
           KI GPGN FV  AK+ V   +D   I+ PAGPSE+L + D  A P+++A++LL+QAEH P
Sbjct: 183 KIVGPGNIFVATAKKLVYGDVD---IEFPAGPSEMLALVDETANPEYIATELLAQAEHDP 239

Query: 265 DSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNA-SRLIVTKDLAQCVEISNQY 323
           ++  IL++ + ++A++  E V   L    R++   ++L+    ++V   +   ++ +N Y
Sbjct: 240 NAATILVSTSKEVAQKTVEHVMEYLKTQKRSDIIEESLSKYGHVLVASSMEDAIDFTNAY 299

Query: 324 GPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGL 383
            PEHL+I T++  + ++SI +AGS+FLG+ +P + GDY SGTNHVLPT G     S L  
Sbjct: 300 APEHLVIVTKDHYKTLESINNAGSIFLGNLTPVAGGDYGSGTNHVLPTSGGARMYSGLSA 359

Query: 384 ADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
             F K+ T+QELS EG   +   +  LA AE L AH  ++  R
Sbjct: 360 ESFLKKPTIQELSPEGVKNIKDMVINLAEAEGLYAHALSIKKR 402


>UniRef50_D0XPF3 Histidinol dehydrogenase n=1 Tax=Brevundimonas subvibrioides ATCC
           15264 RepID=D0XPF3_9CAUL
          Length = 440

 Score =  318 bits (816), Expect = 2e-85,   Method: Compositional matrix adjust.
 Identities = 178/431 (41%), Positives = 253/431 (58%), Gaps = 13/431 (3%)

Query: 7   IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTAL 66
           IDW S   + +   L RP+  +   +   V+ I + V   G  A+ +++ + D      +
Sbjct: 9   IDWASLDGQGRFDALARPSRRSERDVQDVVSGIFEQVALSGGLAVTQFAERIDGFKPRRI 68

Query: 67  KVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVD---VETQPGVRCQQVTRP 123
            ++ E +AAA + L     +A+ VA +N+  FH A K  P D   VET PGV+ + V RP
Sbjct: 69  AITPEAVAAARDALPPADTRALRVAAENVRVFHQATK--PEDTAFVETTPGVKSKLVWRP 126

Query: 124 VASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQ 179
           + + G+Y+PGG+APLFS++LM A PA +AG    V+ +PP     +   ++ AA    + 
Sbjct: 127 IGAAGIYVPGGTAPLFSSLLMQAIPAEVAGVTTRVVVTPPAKDGSVHPAMILAAAEANLD 186

Query: 180 DVFNVGGAQAIAALAFGT----ESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAG 235
            ++ +GGAQAIAAL +G       +P  DK+FGPGNA+V EAKR  +   +G ++DMPAG
Sbjct: 187 AIWLIGGAQAIAALTYGAVLDDGEIPACDKLFGPGNAYVAEAKRYAAALPNGPSVDMPAG 246

Query: 236 PSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRA 295
           PSE+LVIAD    P+  A+DLLSQAEH  D+QVIL+   A     +   VE QL  LPRA
Sbjct: 247 PSELLVIADRFCDPEIAAADLLSQAEHDADAQVILVCERAATIDAILAEVEEQLTTLPRA 306

Query: 296 ETARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSP 355
           + AR +L+ +R I+  D+A+   +SN YGPEHL IQ  +A  LV SI +AG+VF+G W+ 
Sbjct: 307 DIARASLSEARAILVSDMAEACAVSNLYGPEHLAIQAEDAEALVASIRAAGAVFVGRWAA 366

Query: 356 ESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAER 415
           E+ GDYA+G +HVLPT G   T   +  A F   M+VQ +++ G   L      LA  E 
Sbjct: 367 ETLGDYAAGPSHVLPTDGGARTLGGITTASFMTSMSVQTVTEAGAERLGPIAARLARLEG 426

Query: 416 LTAHKNAVTLR 426
           L AH  A  LR
Sbjct: 427 LEAHARAADLR 437


>UniRef50_P62456 Histidinol dehydrogenase n=127 Tax=Bacteria RepID=HISX_BACC1
          Length = 429

 Score =  314 bits (804), Expect = 5e-84,   Method: Compositional matrix adjust.
 Identities = 169/412 (41%), Positives = 250/412 (60%), Gaps = 7/412 (1%)

Query: 19  QLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASE 78
           +LL   A    E++ R V++I+ NV+  GDEAL  Y+ KFD   +   +VS EE   AS 
Sbjct: 16  KLLRENANIIEETVQRNVSEIVRNVRESGDEALSFYTKKFDGVKIKEFRVSEEEEKRASM 75

Query: 79  RLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPL 138
            + +   +A+  A KNI ++H  QK   +      G+   Q+ RP+ +VG+Y+PGG+A  
Sbjct: 76  FVENSFLEALQEAKKNIISYHEKQKRQSMFDCASEGIIRGQIIRPLENVGVYVPGGTASY 135

Query: 139 FSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCGVQDVFNVGGAQAIAALAF 195
            S+VLM   PA +AG KK+V+ +PP    I   IL AA L GV +++ +GGAQAIAALA+
Sbjct: 136 PSSVLMNVLPAKLAGVKKIVMVTPPREGGIDPHILVAASLAGVDEIYTIGGAQAIAALAY 195

Query: 196 GTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASD 255
           GTES+PKVDKI GPGN +V  AKR+V   ++   IDM AGPSE++VIAD      ++A+D
Sbjct: 196 GTESIPKVDKIVGPGNLYVALAKREVYGIVN---IDMIAGPSEIVVIADETGNAKYIAAD 252

Query: 256 LLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNAS-RLIVTKDLA 314
           LLSQAEH   +  I +T   ++A++V + +ERQL  LPR+E AR+++N +  + +   + 
Sbjct: 253 LLSQAEHDERATAICITTNIELAKKVEKEIERQLETLPRSEIARESINRNGAIFIVPSID 312

Query: 315 QCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGY 374
           + +++SN+  PEHL +  +     +  +  AGS+FLG ++PE  GDY +G NHVLPT G 
Sbjct: 313 EALQLSNEIAPEHLELHIKEPMNALAYVKHAGSIFLGPYAPEPLGDYLAGPNHVLPTSGT 372

Query: 375 TATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
               S L + DF K+ +    ++E    +   I  LA  E L AH  A+ +R
Sbjct: 373 ARFFSPLSVDDFVKKSSFLSYTEEALRDVQHHIVELANKEGLHAHARAIQIR 424


>UniRef50_Q722Y3 Histidinol dehydrogenase n=20 Tax=Firmicutes RepID=HISX_LISMF
          Length = 427

 Score =  310 bits (794), Expect = 6e-83,   Method: Compositional matrix adjust.
 Identities = 168/395 (42%), Positives = 239/395 (60%), Gaps = 7/395 (1%)

Query: 36  VNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAMAVAVKNI 95
           V  I++ VK  GD+AL ++++KFD   +T L+V A +I AAS ++      A+  A  NI
Sbjct: 31  VKTIIEKVKTAGDQALFDFTSKFDGVGLTELRVPAADIQAASAKIEPAFLDALQQAKVNI 90

Query: 96  ETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCK 155
           E+FH+ QK        + GV   Q+ RP+ +VG+Y+PGG+A   S+VLM   PA IAG K
Sbjct: 91  ESFHSKQKQHAFLDSEKDGVIRGQLIRPLETVGVYVPGGTAAYPSSVLMNVLPAKIAGVK 150

Query: 156 KVVLCSPP---PIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNA 212
           ++V+ +PP    I   +L +AQL GV +++ VGGA  IAALA GTES+PKVDKI GPGN 
Sbjct: 151 RIVMITPPGENGINPYVLASAQLAGVDEIYQVGGAHGIAALAHGTESIPKVDKIVGPGNI 210

Query: 213 FVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLT 272
           +V  AKR+V   +D   IDM AGPSE++V+AD  A P F+A+DLLSQAEH   ++ IL+T
Sbjct: 211 YVATAKREVFGLVD---IDMIAGPSEIVVLADENANPAFIAADLLSQAEHDILARAILIT 267

Query: 273 PAADMARRVAEAVERQLAELPRAETARQALNA-SRLIVTKDLAQCVEISNQYGPEHLIIQ 331
            +  +A      +++QL  LPR   A++++    ++I+     +  +I N+  PEHL +Q
Sbjct: 268 TSKKIAEETQNEIDKQLENLPRKAIAQKSIETRGKIIIAATTQEMFDIMNEIAPEHLEVQ 327

Query: 332 TRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMT 391
             N    +  I +AGS+FLG ++ E  GDY +G NHVLPT G     S LG+ DF KR  
Sbjct: 328 LENPMNYLYQIKNAGSIFLGSYASEPLGDYFAGPNHVLPTSGTAKFFSPLGVEDFTKRSA 387

Query: 392 VQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
               +KE  +     I  LA  E L AH  A+ +R
Sbjct: 388 FISYTKEALAKEKDAIVLLAKKEGLDAHAKAIQIR 422


>UniRef50_Q8YSM8 Histidinol dehydrogenase 1 n=16 Tax=Bacteria RepID=HISX1_ANASP
          Length = 431

 Score =  309 bits (792), Expect = 1e-82,   Method: Compositional matrix adjust.
 Identities = 172/409 (42%), Positives = 249/409 (60%), Gaps = 7/409 (1%)

Query: 28  ASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQA 87
           A+  ++ TV DIL +VKARGD A++EY+++FD     +  +SA  IA  + + SDE+K A
Sbjct: 25  ATVDVSGTVRDILAHVKARGDAAVQEYTSRFDHYRPHSHHLSAAFIAEQAAKCSDEVKAA 84

Query: 88  MAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLAT 147
           + +A + I +FH  Q    +      GV+       ++ VG+Y+PGG A   S+VLM A 
Sbjct: 85  LELAAERISSFHQKQLPQDIGYTDTAGVKLGLNWVALSQVGIYVPGGRASYPSSVLMNAL 144

Query: 148 PASIAGCKKVVLCSPPP---IADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVD 204
           PA IAG +++V+  P P   I   +L AAQ+ GV +++++GGAQA+ ALA+GTE++  VD
Sbjct: 145 PAKIAGVERIVMTVPMPHGEINPAVLAAAQVAGVTEIYSIGGAQAVGALAYGTETITPVD 204

Query: 205 KIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGP 264
           KI GPGNA+V EAKRQV        ID  AGPSE+LV+AD    P+++A DLLSQAEH P
Sbjct: 205 KIVGPGNAYVAEAKRQV---FGTVGIDSIAGPSEILVVADRQNNPEWIAWDLLSQAEHDP 261

Query: 265 DSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVEISNQY 323
            +Q IL+T +   A++V  AVE+ L  LP  + A  +  N   +I+ +DLA+ + + NQ 
Sbjct: 262 SAQSILITDSESFAQQVIAAVEQILTTLPSQKVASSSWQNHGAVIIVRDLAESIPLLNQL 321

Query: 324 GPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGL 383
            PEH+ +   N + L   I  AGS+FLG ++PE+ GDY  G NHVLPT       S L +
Sbjct: 322 APEHVELCVDNPQLLASQIKCAGSLFLGRYTPEAIGDYLGGPNHVLPTSRSARFASGLSV 381

Query: 384 ADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNALKE 432
            DF KR+T  E ++     +  +  TLA  E L AH  +V +R+  LK+
Sbjct: 382 YDFLKRITYLECNQAALQKIGQSAVTLAETEGLPAHAGSVAVRLQGLKD 430


>UniRef50_B3WED5 Histidinol dehydrogenase n=21 Tax=Bacilli RepID=B3WED5_LACCB
          Length = 430

 Score =  309 bits (792), Expect = 1e-82,   Method: Compositional matrix adjust.
 Identities = 182/425 (42%), Positives = 253/425 (59%), Gaps = 15/425 (3%)

Query: 16  QQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAA 75
           +Q+  + R A++ +  +   V  I+  V+A GD ALR YS K D  TV   +V    I A
Sbjct: 12  KQQVDIRRTAVAQNTDVQTIVQAIIAKVRAEGDSALRTYSNKLDHVTVNDFQVDQALIDA 71

Query: 76  ASERLSDELKQAMAVAVKNIETFHTAQ-KLPPVDVETQPGVRCQQVTRPVASVGLYIPGG 134
           A  +L  +L +A+ +A  NI ++H  + +   VD      +R Q++T P+A+VGLY+PGG
Sbjct: 72  APAQLPAKLLKALQLAKANITSYHQNEIERGFVDTPNSGIIRGQKIT-PLAAVGLYVPGG 130

Query: 135 SAPLFSTVLMLATPASIAGCKKVVLCSPP------PIADEILYAAQLCGVQDVFNVGGAQ 188
           +A   ST+LM A PA +AG KK+V+ +PP      P+   +L AA L GV  ++ VGGAQ
Sbjct: 131 TAAYPSTILMTAIPAKLAGVKKIVMVTPPQPDGLNPV---VLAAANLAGVDAIYQVGGAQ 187

Query: 189 AIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGAT 248
           AIAALA+GTES+P+VDKI GPGN +V EAK+QV       AIDM AGPSE+ +IAD  A 
Sbjct: 188 AIAALAYGTESIPRVDKIMGPGNRYVAEAKKQV---FGNVAIDMIAGPSEIGIIADESAD 244

Query: 249 PDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRL 307
           P  +A+DLLSQAEH P+++ +++T +  +A  V+E ++ QL  LPR   AR A+ N   +
Sbjct: 245 PIRLAADLLSQAEHDPNARAMMVTTSEKLASAVSEQIDIQLPTLPRESIARAAIENQGFI 304

Query: 308 IVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNH 367
            +   +     + N   PEHL +Q  +    +  I +AGSVFLG  + E  GDY +G NH
Sbjct: 305 AIVATINDAFSLMNTIAPEHLEVQLPDPITYLAQIQNAGSVFLGQNAAEPVGDYVAGPNH 364

Query: 368 VLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRV 427
           VLPT G     S LG+ DF KR    + S E  ++ A  I TLA AE L  H  A+  RV
Sbjct: 365 VLPTAGSARFFSPLGVYDFVKRTQFIQYSSEALASQADAIVTLAQAEGLDGHAEAIIKRV 424

Query: 428 NALKE 432
            A KE
Sbjct: 425 PAAKE 429


>UniRef50_P59399 Histidinol dehydrogenase n=14 Tax=Bacteria RepID=HISX_LACPL
          Length = 428

 Score =  309 bits (791), Expect = 1e-82,   Method: Compositional matrix adjust.
 Identities = 175/398 (43%), Positives = 245/398 (61%), Gaps = 9/398 (2%)

Query: 36  VNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAMAVAVKNI 95
           V +I+ NV   GD A+++Y  +FDK T+T  K+S   I  A   L  ++K A+ +A +NI
Sbjct: 31  VREIIANVIKNGDAAVKDYETQFDKVTLTDFKLSQTVIDDAYNNLDPQVKDALLLAKRNI 90

Query: 96  ETFHTAQKLPP-VDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGC 154
            +FH  +K    +D E QPGV   Q   P+  VGLY+PGG+A   ST+LM A PA IAG 
Sbjct: 91  TSFHEKEKATGFIDAE-QPGVLRGQKLMPLNRVGLYVPGGTAAYPSTLLMSALPAKIAGV 149

Query: 155 KKVVLCSPPP---IADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGN 211
            +V++ +PP    I   +L AA++ GV  ++ VGGAQAIAALA+GTES+P VDKI GPGN
Sbjct: 150 NEVIMVTPPQVDGINPAVLAAAKIAGVDAIYQVGGAQAIAALAYGTESIPAVDKIIGPGN 209

Query: 212 AFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILL 271
            FV  AK+QV  ++   AIDM AGPSE+ ++AD  A P  +A+DLLSQAEH   ++ IL+
Sbjct: 210 IFVATAKKQVFGQV---AIDMVAGPSEIGILADDSADPRQLAADLLSQAEHDRRARPILI 266

Query: 272 TPAADMARRVAEAVERQLAELPRAETARQALNASRLI-VTKDLAQCVEISNQYGPEHLII 330
           T +AD+A+ V++ V  QL  LPR   A  A+N    I V   + +  ++ N   PEHL +
Sbjct: 267 TDSADLAQAVSDNVTSQLKVLPREAIATDAVNEKGFIAVVAKIEEMFDLMNTVAPEHLEV 326

Query: 331 QTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRM 390
           Q +N  + ++ I +AGSVFLG ++ E  GDY +G NH+LPT G     S LG+ DF KR 
Sbjct: 327 QLKNPTQYLNLIKNAGSVFLGRYASEPLGDYVAGPNHILPTSGTARFSSPLGVYDFVKRT 386

Query: 391 TVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVN 428
           +  + +K+  +  A  I TLA  E L  H  A+  R +
Sbjct: 387 SFIQYTKDALAKEAPAITTLARVEGLEGHARAIESRFD 424


>UniRef50_D1YWF4 Histidinol dehydrogenase n=1 Tax=Methanocella paludicola SANAE
           RepID=D1YWF4_METPS
          Length = 423

 Score =  305 bits (780), Expect = 3e-81,   Method: Compositional matrix adjust.
 Identities = 166/403 (41%), Positives = 234/403 (58%), Gaps = 13/403 (3%)

Query: 31  SITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAMAV 90
           S+  T   + D V+  GD A+R+Y+ +FD   +  L+V+ +E+  A E +  E    +  
Sbjct: 25  SVMDTAKKVADEVREGGDAAVRKYTKQFDGVDLRDLEVTDDEMYNAVELIDYETIGHLEK 84

Query: 91  AVKNIETFHTAQKLPPVDV---ETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLAT 147
           A+ NIE FH  Q+ P  D+   E  PG+R  Q   P+  +G Y+PGG+    ST LML  
Sbjct: 85  AIDNIEAFHALQR-PSGDMWLTEISPGIRLGQKFTPLERIGAYVPGGTGSYPSTALMLIV 143

Query: 148 PASIAGCKKVVLCSPP----PIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKV 203
           PA +AG  +++ C+PP     I    L A  + G   +F VGG QAIAA+A+GT+S+PKV
Sbjct: 144 PAQVAGVSEIIACTPPRKDGTIHPLTLTALDMAGADRIFKVGGVQAIAAMAYGTQSIPKV 203

Query: 204 DKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHG 263
           +KI GPGN +VT AK  V    D A IDMPAGPSE++VIAD  A P F+ASD+++QAEH 
Sbjct: 204 EKIVGPGNIYVTAAKMYVR---DAAEIDMPAGPSEIVVIADDTAIPSFIASDMIAQAEHD 260

Query: 264 PDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQCVEISNQY 323
            ++  ILLTP+  +A  V   +ERQ    PR +   +A     + V  DL   VE+ N+ 
Sbjct: 261 VNAMSILLTPSEMLAESVELEIERQKENAPRRQIIDKA--GMGIYVLDDLDAAVEVCNRI 318

Query: 324 GPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGL 383
            PEH+ I  R+    ++ + +AG+V++GD++P +AGDYASG NHVLPT GY    S +  
Sbjct: 319 APEHVEIMVRDPMSTLNKVRNAGTVYVGDYAPVAAGDYASGANHVLPTGGYAKVFSGMNT 378

Query: 384 ADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
             F K  +VQ + K G   +  TI  LA  E   AH  +V  R
Sbjct: 379 MQFIKTTSVQVIEKGGLEGIKDTITALAEIEGFDAHARSVYKR 421


>UniRef50_Q46J19 Histidinol dehydrogenase n=60 Tax=Bacteria RepID=HISX_PROMT
          Length = 449

 Score =  305 bits (780), Expect = 3e-81,   Method: Compositional matrix adjust.
 Identities = 163/415 (39%), Positives = 249/415 (60%), Gaps = 10/415 (2%)

Query: 18  RQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAAS 77
           R++  R + +  +   + V+DIL NV+ RGDEAL EY+++FD       +VS++ I  A 
Sbjct: 34  RKITERTSGTVQDEAIKVVDDILKNVRERGDEALTEYTSRFDGFLTEKFQVSSDLILKAW 93

Query: 78  ERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQP-GVRCQQVTRPVASVGLYIPGGSA 136
           E    EL+ ++ +A K IE FH+ Q +P     T P G    +   PV   G+Y+PGG A
Sbjct: 94  EETPRELQDSLLLAKKRIEKFHSLQ-VPKNITYTGPNGETLGRRWSPVEKAGIYVPGGRA 152

Query: 137 PLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQDVFNVGGAQAIAA 192
              STVLM A PA +AG  ++++ SP      I   +L AA + G+  +F +GGAQAI A
Sbjct: 153 AYPSTVLMNAIPAYVAGVNQIIMVSPANSQGEINQTVLAAAHITGINKIFRLGGAQAICA 212

Query: 193 LAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFV 252
           LA GTES+PKVD I GPGN +VT AK++V  ++    ID  AGPSE+L+IAD  A  + V
Sbjct: 213 LASGTESIPKVDVITGPGNIYVTLAKKKVYGKV---GIDSLAGPSEILIIADQSAKLEHV 269

Query: 253 ASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTK 311
           ASD+L+Q+EH P +  IL+T    +A ++   + RQL   PR +  ++++ N   +++  
Sbjct: 270 ASDMLAQSEHDPLASAILITTNTKLAEKLPAEINRQLINHPRLKICQESISNWGLIVLCD 329

Query: 312 DLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPT 371
           DL  C ++S+ + PEHL +   + ++L +SI +AG++F+G WSPE+ GDY  G NH LPT
Sbjct: 330 DLETCAQLSDTFAPEHLELLVEDPKKLSESINNAGAIFMGPWSPEAIGDYLGGPNHTLPT 389

Query: 372 YGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
            G      +LG+  F K  ++ + SKE F+   + +  LA +E L +H  ++ +R
Sbjct: 390 SGTARFAGALGVETFMKNTSLIDFSKEAFNENKNAVVQLANSEGLHSHAESIRIR 444


>UniRef50_Q39YP7 Histidinol dehydrogenase n=54 Tax=Bacteria RepID=HISX_GEOMG
          Length = 436

 Score =  305 bits (780), Expect = 3e-81,   Method: Compositional matrix adjust.
 Identities = 171/408 (41%), Positives = 246/408 (60%), Gaps = 10/408 (2%)

Query: 32  ITRTVNDILDNVKARGDEALREYSAKFDK---TTVTALKVSAEEIAAASERLSDELKQAM 88
           + + V DI+ +V+ARGDEAL EY+ +FD+    +V +L+V+ +E+  A  R+ DE   A+
Sbjct: 29  VEQVVLDIIADVRARGDEALLEYTRRFDRLEADSVASLQVTEDEVDYAFARVKDEEIAAL 88

Query: 89  AVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATP 148
            +AV+ +  FH  QK        +P +   Q+  P+  VG+Y+PGG A   S+V+M A P
Sbjct: 89  KLAVERVARFHEKQKQETWLSTGEPDILLGQMVTPLERVGIYVPGGKASYPSSVIMNAVP 148

Query: 149 ASIAGCKKVVLCSPPP---IADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDK 205
           A +AG  +VV+ +P P   I   +L AA+  GV  +F +GGAQA+AALA+GT +VPKVDK
Sbjct: 149 ARVAGVGEVVMVAPTPGGEINPHVLVAARFSGVDRIFRLGGAQAVAALAYGTATVPKVDK 208

Query: 206 IFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPD 265
           I GPGN +V  AK+ V  ++    IDM AGPSE+LVI D   TP  +A+DLLSQAEH   
Sbjct: 209 ITGPGNIYVATAKKLVFGQV---GIDMIAGPSEILVINDGSGTPAHIAADLLSQAEHDEL 265

Query: 266 SQVILLTPAADMARRVAEAVERQLAELPRAETARQALNA-SRLIVTKDLAQCVEISNQYG 324
           +  IL+T       RVA  VERQLAEL R   AR++      +IV   L + +  SN+  
Sbjct: 266 ASSILITTDRGFGERVAAEVERQLAELSRETIARRSWETYGAVIVAGSLDEAIAFSNRIA 325

Query: 325 PEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLA 384
           PEHL +   N  +++  I +AG++FLG ++PE+AGDY +G NH LPT G     S L + 
Sbjct: 326 PEHLELAVTNPFDVLPKIRNAGAIFLGHFTPEAAGDYLAGPNHTLPTGGTARFFSPLSVD 385

Query: 385 DFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNALKE 432
           DF K+ ++   S+ G + L   I  +A  E L AH  +V++R+    E
Sbjct: 386 DFVKKSSIVYFSESGLNRLGGGIVRIAELEGLEAHGRSVSVRLKGEGE 433


>UniRef50_Q1Q2D0 Histidinol dehydrogenase n=1 Tax=Candidatus Kuenenia
           stuttgartiensis RepID=Q1Q2D0_9BACT
          Length = 439

 Score =  304 bits (778), Expect = 4e-81,   Method: Compositional matrix adjust.
 Identities = 165/415 (39%), Positives = 257/415 (61%), Gaps = 11/415 (2%)

Query: 26  ISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVT--ALKVSAEEIAAASERLSDE 83
           +++S  I  TV  I+ +VK  GD+A+  Y  +FDK  ++    +V  EEI  A + ++ +
Sbjct: 25  LNSSSDIRTTVLKIIQDVKKNGDKAIAAYGKRFDKAPLSPEQFRVKEEEIEDAYKYVTGK 84

Query: 84  LKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVL 143
             +A+ +A+KNI+T+    ++  V      GV    +  P+ S G+Y+PGG+A   STVL
Sbjct: 85  FIKAIRLAIKNIQTYQNHIRIQNVKPLRSKGVILDTIYTPIDSAGIYVPGGAASYPSTVL 144

Query: 144 MLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQDVFNVGGAQAIAALAFGTES 199
           M A PA +AG +K+V+ SPP     I  E L AA+  GV +++ +GG QAIAALAFGT++
Sbjct: 145 MNAIPAQVAGVEKIVMVSPPKEDGNIPPERLVAAKEAGVSEIYKIGGVQAIAALAFGTKT 204

Query: 200 VPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQ 259
           +P VDKI GPGN FVT AK+++      A IDM AGPSEVL+IAD+ A P ++ASDLLSQ
Sbjct: 205 IPSVDKIVGPGNVFVTLAKKEI---FGYAGIDMLAGPSEVLIIADNHANPSYIASDLLSQ 261

Query: 260 AEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLI-VTKDLAQCVE 318
           AEH P    +L+T +  +A++V   +  Q+  L R+    + L    +I +TK++ +C+ 
Sbjct: 262 AEHTPGIS-LLVTSSKLLAKQVLAEITLQIKTLSRSAGTNECLCKYGVIFITKNMNECIA 320

Query: 319 ISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATC 378
           +SN   PEHL I T+N + ++  I  AG+VF+GD++P + GDY +G +HVLPT G     
Sbjct: 321 LSNAIAPEHLQIMTQNPKAVLSGIKHAGAVFVGDYTPVALGDYIAGPSHVLPTGGTARFS 380

Query: 379 SSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNALKEQ 433
           S L + DF KR +V   S+    ++   +  ++A+E L AH  +V +R+++ +++
Sbjct: 381 SGLSVNDFIKRTSVITYSQSALRSVQQDVSEISASEGLDAHAKSVKIRLDSGRKK 435


>UniRef50_Q5FS83 Histidinol dehydrogenase n=3 Tax=Bacteria RepID=HISX_GLUOX
          Length = 430

 Score =  303 bits (776), Expect = 8e-81,   Method: Compositional matrix adjust.
 Identities = 176/408 (43%), Positives = 246/408 (60%), Gaps = 9/408 (2%)

Query: 27  SASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA--LKVSAEEIAAASERLSDEL 84
           S   S+   V  IL +V++RGDEAL +Y+A+FD+ T+ A  L++SAEEIA+ + R+  +L
Sbjct: 24  SDERSVAEPVRAILADVRSRGDEALCDYTARFDRLTLPAEKLRISAEEIASEAARVPADL 83

Query: 85  KQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLM 144
             A+  A + IETFH AQ    +D   + G+R      P+ +VGLY+PGG A   S+VLM
Sbjct: 84  MDALRTAARRIETFHAAQMPKDLDFTDEDGIRLGMRWTPLDAVGLYVPGGKAAYPSSVLM 143

Query: 145 LATPASIAGCKKVVLCSPPP---IADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVP 201
            A PA +AG K++ +C P P   +   +L AAQLCGV++++ +GGAQA+ A+AFGT+ + 
Sbjct: 144 NALPARVAGVKRLAMCVPSPDGVLNPLVLAAAQLCGVEEIYRIGGAQAVGAMAFGTDLIA 203

Query: 202 KVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAE 261
            VD+I GPGNA+V EAKRQV   +    ID  AGPSEV+V+AD    P  VA DLL+QAE
Sbjct: 204 PVDRIVGPGNAYVAEAKRQVFGHV---GIDSIAGPSEVVVVADGQNDPRLVALDLLAQAE 260

Query: 262 HGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVEIS 320
           H   +Q IL+T  A  A R AEAV ++L  LPR   A ++  +   +IV + L +  EI 
Sbjct: 261 HDEQAQAILITTDAAFAERAAEAVRKELETLPRTAIASKSWEDHGAIIVVRSLEEAAEIV 320

Query: 321 NQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSS 380
           N   PEHL +     R+    I  AG++F+G + PE+ GDY  G NHVLPT       S 
Sbjct: 321 NALAPEHLEVMLDAPRDFSAMIRHAGAIFMGRYCPEAVGDYVGGPNHVLPTSRTARFASG 380

Query: 381 LGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVN 428
           L + DF KR T  E  + G   +      LA AE L AH  ++++R+ 
Sbjct: 381 LSVFDFIKRTTTIEADEAGLRRIGPAGVALAKAEGLDAHALSLSVRLE 428


>UniRef50_Q64EP7 Histidinol dehydrogenase n=2 Tax=environmental samples
           RepID=Q64EP7_9ARCH
          Length = 419

 Score =  303 bits (776), Expect = 9e-81,   Method: Compositional matrix adjust.
 Identities = 174/405 (42%), Positives = 243/405 (60%), Gaps = 28/405 (6%)

Query: 36  VNDILDNVKARGDEALREYSAKFDKTTV---TALKVSAEEIAAASERLSDELKQAMAVAV 92
           VN+I+  VK+RGD AL +Y+ KFD         L+V   EI  A   + D L +++  A 
Sbjct: 28  VNEIIAEVKSRGDRALLDYTEKFDGVKFLRQKDLEVRRSEIEDAKRNVDDHLLRSIEKAS 87

Query: 93  KNIETFHTAQKLPPVDVET------QPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLA 146
           + I+ FH  QK   V+VE         G+       P+  VG Y+P   A  FST LM  
Sbjct: 88  EAIKKFHYRQK-RRVEVEKGEDKGGTEGMFIDNTYVPLDVVGAYVP---ASYFSTALMCV 143

Query: 147 TPASIAGCKKVVLCSPPPIADEI-----LYAAQLCGVQDVFNVGGAQAIAALAFGTESVP 201
            PA IAG + +++C+PP     +     L AA+L G   +F VGGAQAIAALAFGTE++P
Sbjct: 144 IPAKIAGVRNILVCTPPGKDGAVDSLTLLAAAELAGATRIFKVGGAQAIAALAFGTETIP 203

Query: 202 KVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAE 261
           KV KI GPGN +VT AK  ++ R  G  ID PAGPSE+++IAD  A P F+ +D+L+QAE
Sbjct: 204 KVQKIVGPGNVYVTAAK--MAARAQGVEIDFPAGPSEIIIIADETANPLFIVADMLAQAE 261

Query: 262 HGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQCVEISN 321
           HG  S+ +LLT +A    R+A  VERQ+    R E   +    + +I+  D+ +C+E++N
Sbjct: 262 HGAKSKAVLLTDSA----RIAAEVERQI----RTEAGDEEGEQNGIILGDDIGECIELAN 313

Query: 322 QYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSL 381
           +Y PEHL I  R  +E++  I +AGSVF+GD+SP +AGDYA+G NHVLPT GY  + S L
Sbjct: 314 EYAPEHLEIMVREPKEVLKRIKNAGSVFVGDYSPVAAGDYATGANHVLPTAGYAKSFSGL 373

Query: 382 GLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
            +  F +RMTVQ L KEG + +   +  ++ AE +  H  +V  R
Sbjct: 374 DVHHFMRRMTVQWLDKEGLAKIKDVVVKMSRAEGMEKHAQSVEAR 418


>UniRef50_Q02136 Histidinol dehydrogenase n=9 Tax=Bacteria RepID=HISX_LACLA
          Length = 431

 Score =  301 bits (770), Expect = 4e-80,   Method: Compositional matrix adjust.
 Identities = 166/431 (38%), Positives = 250/431 (58%), Gaps = 11/431 (2%)

Query: 7   IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA- 65
           ID+     E   +   R     S+ + +TV  I+ +++  GD AL  Y+ KFD   V   
Sbjct: 5   IDYQGKLEEIAEKFQGRKT-EVSKEVNKTVQQIVADIQKNGDTALFNYAKKFDGYDVNTS 63

Query: 66  -LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPV 124
            L V+  E  A  E++ ++  + +      IE FH  Q     ++  + GV   Q+ RP+
Sbjct: 64  NLLVTRMEREAGLEQIDEDYFRILRRTKSQIEEFHKHQLGNSWNIFKENGVIMGQIARPL 123

Query: 125 ASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSP----PPIADEILYAAQLCGVQD 180
             V LY+PGG+A   STV+M A PA +AG K++++ +P      +   IL AA++CG++ 
Sbjct: 124 ERVALYVPGGTAAYPSTVIMNAVPALLAGVKEIIMITPVKADGKVNPNILAAAEVCGIET 183

Query: 181 VFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVL 240
           ++ VGGAQ +AA+A+GTES+PKVDKI GPGN FV  AK+     +D   IDM AGPSEVL
Sbjct: 184 IYKVGGAQGVAAVAYGTESIPKVDKIVGPGNIFVATAKKICYGVVD---IDMIAGPSEVL 240

Query: 241 VIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQ 300
           VIAD  A P ++A+DL++QAEH   +  IL+T +  + ++V E + RQ+  L R E    
Sbjct: 241 VIADKTAKPKYIAADLMAQAEHDKLASAILVTTSEKLVQQVDEELNRQVQNLERREIIES 300

Query: 301 AL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAG 359
           ++ N    IV K++    ++SNQ  PEHL + T      +  I +AGS+F+G+++PE  G
Sbjct: 301 SIRNYGGAIVVKNIDDAFDVSNQLAPEHLEVLTSEPLTQLPKIKNAGSIFIGEYTPEPLG 360

Query: 360 DYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAH 419
           DY SG+NHVLPT G     S LG+ +F K +T     KE  +     +ET A +E LTAH
Sbjct: 361 DYMSGSNHVLPTGGTAKFYSGLGVYNFIKYLTYSYYPKEVLADFKEDVETFAKSEGLTAH 420

Query: 420 KNAVTLRVNAL 430
            N++++R + +
Sbjct: 421 ANSISVRFDEM 431


>UniRef50_C0QG33 Histidinol dehydrogenase n=4 Tax=Deltaproteobacteria
           RepID=C0QG33_DESAH
          Length = 432

 Score =  300 bits (767), Expect = 8e-80,   Method: Compositional matrix adjust.
 Identities = 179/431 (41%), Positives = 250/431 (58%), Gaps = 13/431 (3%)

Query: 6   IIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVT- 64
           I  + S   EQ+    ++  +  +    R V   +++V+ RGD+AL EY+ +FD + VT 
Sbjct: 3   IYTYPSPEGEQRICDTLKRGLGFTPENQRAVEAYIEDVRTRGDQALVEYTNQFDSSQVTR 62

Query: 65  -ALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRP 123
             LKVS +EI  A   +  +  +A+  AV  + TFH+ Q+        + GV   Q+  P
Sbjct: 63  DTLKVSQQEIEEAKTLVDSDFSRALDRAVDQLGTFHSRQRQNSWIDTPRNGVMVGQMVNP 122

Query: 124 VASVGLYIPG---GSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLC 176
           V + G+Y PG   G  PL S+VLM   PA +AG K   L +PP     I   +L AA   
Sbjct: 123 VDAAGIYAPGAKGGKTPLVSSVLMGGIPARVAGVKSCCLMTPPMENGKINPYMLVAADRV 182

Query: 177 GVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGP 236
           G+  +F  G A AIAALAFGTESVPKVD I GPGN FVT AK+ VS  +    IDM AGP
Sbjct: 183 GINAIFKAGSAWAIAALAFGTESVPKVDVIVGPGNIFVTLAKKIVSGIV---GIDMIAGP 239

Query: 237 SEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAE 296
           SE+L+IAD GA PD +A+DLLSQAEH P +  IL+T + +MA R   A+E Q+  L R +
Sbjct: 240 SEILIIADKGANPDHIAADLLSQAEHDPMASAILVTDSMEMATRTKAALEIQVKALGRRQ 299

Query: 297 TARQALNASRLIV-TKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSP 355
            A+++++    I+   D+   + ++N+  PEHL +   N  + V  I +AG+VFLG ++P
Sbjct: 300 IAQRSIDDFGAIMKVPDIDTAIALANRLAPEHLELIVDNPFDQVGKIKNAGAVFLGPYTP 359

Query: 356 ESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAER 415
           E  GDY +G NHVLPT G     S+LG+ +F KR ++   SKE F   A  +  LA  E 
Sbjct: 360 EPMGDYIAGPNHVLPTAGTARFSSALGVDNFTKRTSLINYSKEAFDREAQDVMVLANIEG 419

Query: 416 LTAHKNAVTLR 426
           L AH N+V +R
Sbjct: 420 LGAHANSVRIR 430


>UniRef50_C0GFZ9 Histidinol dehydrogenase n=1 Tax=Dethiobacter alkaliphilus AHT 1
           RepID=C0GFZ9_9FIRM
          Length = 432

 Score =  300 bits (767), Expect = 8e-80,   Method: Compositional matrix adjust.
 Identities = 184/422 (43%), Positives = 245/422 (58%), Gaps = 8/422 (1%)

Query: 18  RQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAAS 77
           R+   R         T+ V DIL  V  RGDEA+ EY+ KFD   +  L VS EE AAA 
Sbjct: 11  RETFTRAGFDDYPEATQAVRDILAEVNQRGDEAVLEYTRKFDGVELETLLVSEEEFAAAE 70

Query: 78  ERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAP 137
           E +  E++Q++  A +NI  FH  Q           GV   Q    V   G Y+PGG A 
Sbjct: 71  EAVDPEVRQSLVEAAENIRDFHRRQVQNSWLEHQADGVALGQRVTAVEKAGAYVPGGGAA 130

Query: 138 LFSTVLMLATPASIAGCKKVVLCSPPPIADEI----LYAAQLCGVQDVFNVGGAQAIAAL 193
             S+VLM   PA +AG +KVVL +PP    EI    L AA++ G   V+  GGAQA+AAL
Sbjct: 131 YPSSVLMTVIPARVAGVEKVVLVTPPQAGGEINPYTLVAAKIAGADAVYKCGGAQAVAAL 190

Query: 194 AFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVA 253
           A+GTE+VPKVDKI GPGN +VT AKR+VS  +    IDM AGPSEVLV+AD+ A  DFVA
Sbjct: 191 AYGTETVPKVDKIVGPGNLYVTLAKREVSGMV---GIDMLAGPSEVLVVADASARADFVA 247

Query: 254 SDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNA-SRLIVTKD 312
           +DLLSQAEH   +    +T +A +A  + + ++RQ A+L R + AR++L     L++   
Sbjct: 248 ADLLSQAEHDVMAASYCVTTSARLALDLQKELKRQCAQLERCDVARESLQQQGALVIVDS 307

Query: 313 LAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTY 372
           L + +EI N+  PEHL +Q     E +  + +AG+VF+G ++PE  GDY +G NHVLPT 
Sbjct: 308 LDEALEIVNELAPEHLELQLSEPWEALGKVKNAGAVFVGPYTPEPVGDYWAGPNHVLPTA 367

Query: 373 GYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNALKE 432
           G     S L + DF K+ +V   S +     A  IE LA  E LTAH  AV +R   L+E
Sbjct: 368 GAGRFSSVLSVDDFVKKTSVIYYSPQALLKSAQKIEGLARVEGLTAHGQAVKIRREYLEE 427

Query: 433 QA 434
           + 
Sbjct: 428 KG 429


>UniRef50_Q1IKB6 Histidinol dehydrogenase n=1 Tax=Candidatus Koribacter versatilis
           Ellin345 RepID=Q1IKB6_ACIBL
          Length = 415

 Score =  299 bits (765), Expect = 2e-79,   Method: Compositional matrix adjust.
 Identities = 183/395 (46%), Positives = 254/395 (64%), Gaps = 18/395 (4%)

Query: 36  VNDILDNVKARGDEALREYSAKFDKTTVTA-LKVSAEEIAAASERLSDELKQAMAVAVKN 94
           V  I+ +V+  GD ALR Y++K D    TA L+VS EE+ +A +    E KQA+  A KN
Sbjct: 31  VRKIVVDVRKNGDAALRRYASKLDGLGKTAALRVSTEELKSAWDATRSEFKQAIRAAAKN 90

Query: 95  IETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGC 154
           IE F   Q       +   G+   Q+ RP+ SVG Y+PGG  PL STVLM   PA +AG 
Sbjct: 91  IERFARWQMPKSWTRDAGDGIELGQIIRPIESVGCYVPGGRYPLPSTVLMTVVPARVAGV 150

Query: 155 KKVVLCSPPPIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFV 214
           ++VV+ SP P A E L AA L GV + + +GGAQA+AALA+GTESV +V KI GPGN FV
Sbjct: 151 ERVVVVSPNP-ARETLAAAYLLGVGEFYRIGGAQAVAALAYGTESVERVAKIVGPGNIFV 209

Query: 215 TEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPA 274
           T AK+ V+   D  AIDM AGP+E  ++++ G    F+A+DL++QAEH P++ V   T +
Sbjct: 210 TTAKKLVA--FD-CAIDMLAGPTEAAIVSERG-NARFIAADLVAQAEHDPETMVAFFTTS 265

Query: 275 ADMARRVAEAVERQLAELPRAET-ARQALNASR--LIVTKDLAQCVEISNQYGPEHLIIQ 331
             +A    +AV++Q+A L    T AR+AL A+R  + V +D+AQ +E +NQ+  EHL + 
Sbjct: 266 PSLA----DAVKKQVALLAAKNTIARKAL-ATRGYIFVAQDIAQAMEAANQFASEHLTVD 320

Query: 332 TRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMT 391
                +L+++++SAGSVF+GD+S +S GDYASG NHVLPT G       L + D+ K +T
Sbjct: 321 ----EDLLETVSSAGSVFVGDYSAQSFGDYASGPNHVLPTGGLARVRGGLSVLDYVKIIT 376

Query: 392 VQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
           VQ++S++G  ALA   ETLAAAE L AH  +V +R
Sbjct: 377 VQKISRKGLRALAPIAETLAAAEGLVAHGQSVAIR 411


>UniRef50_Q186D5 Histidinol dehydrogenase n=9 Tax=Bacteria RepID=Q186D5_CLOD6
          Length = 421

 Score =  298 bits (764), Expect = 2e-79,   Method: Compositional matrix adjust.
 Identities = 161/407 (39%), Positives = 235/407 (57%), Gaps = 13/407 (3%)

Query: 30  ESITRT-VNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAM 88
           E I R  V+ I+++++   D AL++Y+ KFD+ T    +++ EEI  A + + DE    +
Sbjct: 15  EKILREQVSSIIEDIRNNKDVALKKYNEKFDRNTRDEFRITKEEIKEAYKHVDDEFINNL 74

Query: 89  AVAVKNIETFHTAQKLP---PVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLML 145
            +A KNI  F  AQKL    P + E  PGV   Q   P+ S   Y+PGG  PLFST LML
Sbjct: 75  KIAAKNIREFAKAQKLSFENPFEKEIYPGVILGQTNIPIESCLAYVPGGQYPLFSTALML 134

Query: 146 ATPASIAGCKKVVLCSP-----PPIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESV 200
             PA +AG K++V CSP       I  + L A  + G  +++  GG QAIAA  +GTE +
Sbjct: 135 IIPAKVAGVKRIVACSPTMKNTEKINPKTLVAMDIAGADEIYATGGVQAIAAFTYGTEKI 194

Query: 201 PKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQA 260
             VD I GPGN FVTEAKRQ   ++    ID  AGPSEVL+IAD  + P ++A+DLL+Q 
Sbjct: 195 NPVDIIVGPGNKFVTEAKRQCYGQV---GIDFVAGPSEVLIIADETSNPVYIAADLLAQC 251

Query: 261 EHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVEI 319
           EH  +++ ILLT + ++A++V + +E  L +LP  + +  +  N   +I+  D+ + ++I
Sbjct: 252 EHDLNARGILLTNSLEVAQKVEKNIESMLKDLPTKDISYSSWENNGEIILVDDMEEAIKI 311

Query: 320 SNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCS 379
           SN Y PEHL +      ++ D +T+ GS+F+G+ S E  GDY SGTNH LPT   +    
Sbjct: 312 SNFYAPEHLEVAVNEYNDICDRLTNYGSLFIGNLSAEVFGDYVSGTNHTLPTLKASRYTG 371

Query: 380 SLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
            + +  F K  T Q  +++   +LA   E LA  E L AH  A  +R
Sbjct: 372 GVWVGTFIKTCTKQIFNEKAIQSLAPVAEKLAKEEGLYAHAKAAEVR 418


>UniRef50_Q30TA4 Histidinol dehydrogenase n=16 Tax=Epsilonproteobacteria
           RepID=HISX_SULDN
          Length = 430

 Score =  298 bits (762), Expect = 4e-79,   Method: Compositional matrix adjust.
 Identities = 168/426 (39%), Positives = 255/426 (59%), Gaps = 13/426 (3%)

Query: 10  NSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA---L 66
           NS    + ++LL R  +  +  ++ TV  I+D +K+  ++AL+E+  KFDK T  +   L
Sbjct: 8   NSSFKAEFKELLERGKMDIAH-VSATVGTIIDEIKSNKNQALKEHITKFDKWTPVSDEDL 66

Query: 67  KVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQP-GVRCQQVTRPVA 125
           K+S E ++ A E L   LK A+ ++   I+ +H  QK P    + +P G    Q   PV 
Sbjct: 67  KISTESMSRAYENLDKALKAALHLSYDRIKAYHEKQK-PRSWFDDEPNGTILGQRVTPVD 125

Query: 126 SVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPI--ADEILYAA-QLCGVQDVF 182
           S GLYIPGG A   S++LM   PA +AG + +V+C+P P    +E+L AA  LCGV +V+
Sbjct: 126 SAGLYIPGGKAAYPSSLLMNVIPAQVAGVQNIVVCTPTPENEPNELLLAACHLCGVSEVY 185

Query: 183 NVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVI 242
            VGGA AIAA+A+GTE++PKVD I GPGN FV  AK+ V   ++   IDM AGPSE+ ++
Sbjct: 186 KVGGASAIAAMAYGTETIPKVDVITGPGNIFVATAKKMVFGDVN---IDMIAGPSEIGIL 242

Query: 243 ADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL 302
           AD  A P  +A D+LSQAEH   +  IL+TP+  +A  +   +E  L  LPR + AR+++
Sbjct: 243 ADDSANPSHMAVDMLSQAEHDEMASSILITPSQKLADAIKAEIENWLKILPRQKIARESI 302

Query: 303 NA-SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDY 361
                +IVT D+ + +++ N+  PEHL + T +  EL+  I  AG++FLG  +PE+ GDY
Sbjct: 303 EKRGAIIVTSDMQEAIDLMNEIAPEHLEVATLSPFELLPLIKHAGAIFLGHNTPEAVGDY 362

Query: 362 ASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKN 421
            +G NH LPT G     S LG+ +F K+ ++   S +  + +      +A  E LTAH+ 
Sbjct: 363 MAGPNHTLPTGGTAKFFSPLGVENFMKKTSIISFSAKAINEIGEECALIAKIEGLTAHEQ 422

Query: 422 AVTLRV 427
           ++ +R+
Sbjct: 423 SIRVRL 428


>UniRef50_D0LM64 Histidinol dehydrogenase n=2 Tax=Nannocystineae RepID=D0LM64_HALO1
          Length = 438

 Score =  296 bits (759), Expect = 8e-79,   Method: Compositional matrix adjust.
 Identities = 185/423 (43%), Positives = 253/423 (59%), Gaps = 16/423 (3%)

Query: 18  RQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA---LKVSAEEIA 74
           R LL R    ASE + R V DIL  V+ARGDEA+R ++ KFD  +  A    ++   +  
Sbjct: 18  RALLERSTSFASE-VERAVADILAEVRARGDEAVRAFTEKFDGRSPRAGSSYEIPPGDWR 76

Query: 75  AASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQ-----PGVRCQQVTRPVASVGL 129
            A   L+ E+  A+  A + +  FH  Q    VD          G+R      P++ VG+
Sbjct: 77  RAKGELAPEVLAALEQAAERVRAFHARQA--EVDRAADFSLDGGGMRLDLRIDPLSRVGI 134

Query: 130 YIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVFNVGGAQA 189
           Y+PGG+A   S+VLM A PA IAG  ++++ +P   + E L AA L GV  VF +GGAQA
Sbjct: 135 YVPGGTARYPSSVLMTAIPARIAGVDEIIMVTPG-ASKETLAAAALAGVDRVFEIGGAQA 193

Query: 190 IAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATP 249
           +AALA+GTESVP+VDKI GPGN +V  AKRQV   +D   ID  AGPSEVL++AD  A P
Sbjct: 194 VAALAYGTESVPRVDKIVGPGNQWVAAAKRQVFGVVD---IDSVAGPSEVLILADDSANP 250

Query: 250 DFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLI 308
            +VA+DLL+QAEH P +  +L T +  +A  V E + RQLA+LPRA+ AR AL N    +
Sbjct: 251 RWVAADLLAQAEHDPLAHPVLATTSPALADAVDEELARQLADLPRADIARTALANQGAAV 310

Query: 309 VTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHV 368
           +  D    V  +N+Y PEHL +  R  R ++  + +AG++F+G  + E+AGDY +G NHV
Sbjct: 311 LVPDQGAAVAFANRYAPEHLELHLREPRAVLGQLRTAGAIFVGALAAEAAGDYMAGPNHV 370

Query: 369 LPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVN 428
           LPT G     S LG+ DF+K  ++ E   E   A A  I  LAA E L AH  ++TLR +
Sbjct: 371 LPTGGAARYASPLGVYDFRKHTSIIEYQAEAVLAQADAIAALAAVEGLDAHGRSMTLRRD 430

Query: 429 ALK 431
           AL+
Sbjct: 431 ALR 433


>UniRef50_D2RJQ0 Histidinol dehydrogenase n=7 Tax=Firmicutes RepID=D2RJQ0_ACIFE
          Length = 448

 Score =  296 bits (757), Expect = 1e-78,   Method: Compositional matrix adjust.
 Identities = 177/420 (42%), Positives = 256/420 (60%), Gaps = 17/420 (4%)

Query: 19  QLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV--TALKVSAEEIAAA 76
           ++  RP ++A+E +   VNDI    + +GDEAL EY+ K D   +    ++V+ EE A A
Sbjct: 38  KMFGRP-LTAAEEVDIIVNDI----RNKGDEALFEYTKKLDGADLRPATIRVTEEEFAEA 92

Query: 77  SERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQP-GVRCQQVTRPVASVGLYIPGGS 135
            + + ++   A+  A+ N+  FH  Q LP   +  +  G    Q   PV SVG+Y+PGG+
Sbjct: 93  EKAVDEKTMGAIRRAIANVRKFHEEQ-LPKTWLTPRAYGSFLGQKMTPVDSVGIYVPGGT 151

Query: 136 APLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQDVFNVGGAQAIA 191
           A   S+V+M A PA +AG  ++ + +P      +   +L  A+  G+ +++ +GGAQAIA
Sbjct: 152 AAYPSSVIMNAVPAKVAGVPRIAMAAPAGRDGKMNPYVLATAKEIGITEIYKMGGAQAIA 211

Query: 192 ALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDF 251
           ALAFGTE++PKV+KI GPGN FVT AK+ V   +D   IDM AGPSE+L++AD  A   +
Sbjct: 212 ALAFGTETIPKVEKITGPGNIFVTLAKKAVYGHVD---IDMLAGPSEILIVADKTADYQY 268

Query: 252 VASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNA-SRLIVT 310
           +A+DLLSQAEH P +  IL+T   D+A +VAE VE QL +LPR E A Q+L    ++I+ 
Sbjct: 269 LAADLLSQAEHDPLACAILITDDEDLAGKVAEEVEVQLQKLPRKEIAAQSLAVQGKIILA 328

Query: 311 KDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLP 370
           KD+   VE++N   PEH+ I TR    LV  I +AG++FLG +SPE  GDY +G NH+LP
Sbjct: 329 KDMDTVVEMANISAPEHMEINTREPFALVPRIRNAGAIFLGAYSPEPLGDYYAGPNHILP 388

Query: 371 TYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNAL 430
           T G     S L +  F K+ ++   +KE  +  A  I  +A AE L AH NA+ +R  AL
Sbjct: 389 TGGTARFYSVLNVETFMKKTSIISYTKEALAEAADDIIAMAEAEGLQAHANAIRIRKGAL 448


>UniRef50_B2A652 Histidinol dehydrogenase n=1 Tax=Natranaerobius thermophilus
           JW/NM-WN-LF RepID=B2A652_NATTJ
          Length = 428

 Score =  295 bits (754), Expect = 3e-78,   Method: Compositional matrix adjust.
 Identities = 165/404 (40%), Positives = 239/404 (59%), Gaps = 13/404 (3%)

Query: 34  RTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAMAVAVK 93
            TV  I+D V+  GD+AL E +   D  +++ L+VS E +    + L+D+ K+A+  A  
Sbjct: 23  NTVTKIIDQVRTNGDKALFELTQSLDNCSLSKLEVSQEYMKQCYDNLTDKTKEALNFAKD 82

Query: 94  NIETFHTAQ--KLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASI 151
            IE F + Q      ++ E  PGV+     +P++S G Y+P G  PL S+ LM   PA +
Sbjct: 83  QIEFFASQQLAGFKEIECENIPGVKLGYKIKPISSCGCYVPAGRYPLPSSALMSIVPARV 142

Query: 152 AGCKKVVLCSPP-----PIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKI 206
           AG +++V  +PP      I  E+L A  L GV +V+ VGGA  IAALA GTE++ KVD I
Sbjct: 143 AGVERIVAIAPPVRKYGGIHPELLAAMYLAGVDEVYIVGGAHGIAALALGTETISKVDFI 202

Query: 207 FGPGNAFVTEAKRQVSQRLDG-AAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPD 265
            GPGN +VTEAKRQ    L+G   ID  AGPSEVL+IAD+ A+   VA+DLL+QAEH PD
Sbjct: 203 VGPGNKYVTEAKRQ----LNGIVGIDQLAGPSEVLIIADNTASSTNVAADLLAQAEHDPD 258

Query: 266 SQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVEISNQYG 324
           +  +L+T +  +A+ V + + RQL EL   ETA ++  +   +I+  +L Q +EIS+Q  
Sbjct: 259 AVCVLVTTSEQLAKEVNQEIHRQLDELLTWETAAKSWEDYGEIILVDNLDQAIEISDQMA 318

Query: 325 PEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLA 384
           PEHL + T N   +++ +   GS+F+G+W+  + GDY SGTNH+LPT       S L + 
Sbjct: 319 PEHLQLMTDNNSNIMEMVNHYGSLFVGEWASVAFGDYVSGTNHILPTGNSARFSSGLSVG 378

Query: 385 DFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVN 428
            F K  + Q L++ G   L+     LA  E L AHK +  LR +
Sbjct: 379 KFLKMSSYQVLTETGAHELSDKCMHLAELEGLEAHKKSAELRAD 422


>UniRef50_Q46WL2 Histidinol dehydrogenase 1 n=202 Tax=Bacteria RepID=HISX1_RALEJ
          Length = 445

 Score =  293 bits (750), Expect = 8e-78,   Method: Compositional matrix adjust.
 Identities = 172/410 (41%), Positives = 239/410 (58%), Gaps = 14/410 (3%)

Query: 30  ESITRTVNDILDNVKARGDEALREYSAKFDKT---TVTALKVSAEEIAAASERLSDELKQ 86
           E+I R V  IL +VK RGD A+ EY+ +FD+    ++ AL++S  E+ AA E L  + + 
Sbjct: 37  EAIDRAVAQILADVKDRGDAAVLEYTQRFDRVEAASMGALEISQSELEAALEDLEPKRRA 96

Query: 87  AMAVAVKNIETFHTAQKLP----PVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTV 142
           A+  A   +  +H  QK+       +     G    Q   P+  VG+Y+PGG A   S+V
Sbjct: 97  ALEAAAARVRAYHEKQKIECGSHSWEYTEADGTMLGQKVTPLDRVGIYVPGGKAAYPSSV 156

Query: 143 LMLATPASIAGCKKVVLCSPPP--IADE-ILYAAQLCGVQDVFNVGGAQAIAALAFGTES 199
           LM A PA +AG K++++  P P  + +E +L AAQ+ GV  VF +GGAQA+ ALA+GT +
Sbjct: 157 LMNAIPARVAGVKEIIMVVPTPGGVRNELVLAAAQIAGVDRVFTIGGAQAVGALAYGTAT 216

Query: 200 VPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQ 259
           +P+VDKI GPGNA+V  AKR+V        IDM AGPSE+LVI D    PD+VA DL SQ
Sbjct: 217 LPQVDKIVGPGNAYVAAAKRRV---FGTVGIDMIAGPSEILVICDGTTDPDWVAMDLFSQ 273

Query: 260 AEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNA-SRLIVTKDLAQCVE 318
           AEH   +Q ILL P AD   +V  +++RQL  +PR E    +++    LI  +D+ +  E
Sbjct: 274 AEHDELAQSILLCPDADYIAQVEASIQRQLDSMPRREVIAASISGRGALIKVRDMEEACE 333

Query: 319 ISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATC 378
           I+N   PEHL I   N R+  + I  AG++FLG ++ ES GDY +G NHVLPT       
Sbjct: 334 IANAIAPEHLEISAENPRQWSEKIRHAGAIFLGRYTSESLGDYCAGPNHVLPTSRTARFS 393

Query: 379 SSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVN 428
           S LG+ DFQKR ++ E+S+ G   L      LA  E L AH  +   R  
Sbjct: 394 SPLGVYDFQKRSSLIEVSEGGAQMLGQIAAELAYGEGLQAHARSAEYRFK 443


>UniRef50_Q4ZNV9 Histidinol dehydrogenase n=116 Tax=Bacteria RepID=HISX_PSEU2
          Length = 448

 Score =  292 bits (748), Expect = 1e-77,   Method: Compositional matrix adjust.
 Identities = 168/422 (39%), Positives = 240/422 (56%), Gaps = 11/422 (2%)

Query: 14  AEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA---LKVSA 70
           A     LL   ++S  +S+ + V DI+  V+ RGD AL E++ KFD   V +   L +  
Sbjct: 18  ARHLDHLLSWESVS-DDSVNQRVLDIIKAVRERGDAALVEFTQKFDGLQVASMADLILPR 76

Query: 71  EEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLY 130
           E +  A  R++   ++A+  A + + ++H  QK          G    Q   P+   GLY
Sbjct: 77  ERLELALTRITPGQREALEKAAERVRSYHEKQKQDSWSYTEADGTVLGQKVTPLDRAGLY 136

Query: 131 IPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCGVQDVFNVGGA 187
           +PGG A   S+VLM A PA +AG  +VV+  P P   I + +L AA + GV  VF +GGA
Sbjct: 137 VPGGKASYPSSVLMNAIPAKVAGVTEVVMVVPTPRGEINELVLAAACIAGVDRVFTIGGA 196

Query: 188 QAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGA 247
           QA+AALA+GTESVPKVDK+ GPGN +V  AKR V  ++    IDM AGPSE+LV+ D   
Sbjct: 197 QAVAALAYGTESVPKVDKVVGPGNIYVATAKRHVFGQV---GIDMIAGPSEILVVCDGQT 253

Query: 248 TPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNA-SR 306
            PD++A DL SQAEH  D+Q IL++P A+   +VA ++ R L  + RA     ++N    
Sbjct: 254 DPDWIAMDLFSQAEHDEDAQAILVSPDAEFLDKVAASITRLLPTMERAAIVETSINGRGA 313

Query: 307 LIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTN 366
           LI   D+AQ +E++N+  PEHL +   +    +  I  AG++F+G  + E+ GDY +G N
Sbjct: 314 LIKVADMAQAIEVANRIAPEHLELSVADPEAWLPQIRHAGAIFMGRHTSEALGDYCAGPN 373

Query: 367 HVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
           HVLPT G     S LG+ DFQKR ++   S +G S L  T   LA  E L+ H  +   R
Sbjct: 374 HVLPTSGTARFSSPLGVYDFQKRSSIIYCSPQGASELGKTASVLARGESLSGHARSAEYR 433

Query: 427 VN 428
           + 
Sbjct: 434 IT 435


>UniRef50_Q6FEC8 Histidinol dehydrogenase n=50 Tax=Bacteria RepID=HISX_ACIAD
          Length = 430

 Score =  290 bits (743), Expect = 5e-77,   Method: Compositional matrix adjust.
 Identities = 161/402 (40%), Positives = 241/402 (59%), Gaps = 10/402 (2%)

Query: 32  ITRTVNDILDNVKARGDEALREYSAKFDKT---TVTALKVSAEEIAAASERLSDELKQAM 88
           + +TV+ I+ +V+  GDE + + + +FD+      + L+++ E++  A E L+ E+++A+
Sbjct: 30  LLKTVDQIIADVRQYGDEHVLKLTQQFDRHPAHQFSDLELTQEQLKTAFEALTAEIREAL 89

Query: 89  AVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATP 148
            +A + I +FH AQK          G    Q   P+  VG+Y+PGG A   S+VLM A P
Sbjct: 90  ELAAERIRSFHQAQKQEGWSYVDALGNTLGQKVTPLDRVGIYVPGGLASYPSSVLMNAIP 149

Query: 149 ASIAGCKKVVLCSPPP---IADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDK 205
           A +AG  ++++  P P   +   +L AA L GV  +F +GGAQA+AALA+GT+++P VDK
Sbjct: 150 AHVAGVPEIIMVVPAPNGELNSLVLAAAYLAGVSRIFTIGGAQAVAALAYGTQTIPAVDK 209

Query: 206 IFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPD 265
           I GPGN FV  AKR V  ++    IDM AGPSE+LV A+      ++A DLLSQAEH   
Sbjct: 210 ITGPGNRFVAAAKRAVFGQV---GIDMIAGPSEILVYAEGQNNAKWLAMDLLSQAEHDTV 266

Query: 266 SQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVEISNQYG 324
           +Q I +TP   +   VA+A+E  LA LP+A+ AR ++ N   L++ KD  + +E+ NQ  
Sbjct: 267 AQAIFITPDEALLDEVAQAIEEHLAALPKADIARTSIANRGALVLVKDRDEAIELINQVA 326

Query: 325 PEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLA 384
           PEHL +    +  +   I  AG++F+G ++PE+ GDY +G NHVLPT G     S LG+ 
Sbjct: 327 PEHLELCLDESEAMSQKIRHAGAIFMGRYTPEAIGDYCAGPNHVLPTSGTARFSSPLGVY 386

Query: 385 DFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
           DFQKR ++   S+EG  +LA   + LA  E L AH  +   R
Sbjct: 387 DFQKRSSLIMCSQEGVKSLAKAADVLAQQENLDAHARSARYR 428


>UniRef50_P62460 Histidinol dehydrogenase n=15 Tax=Bacteria RepID=HISX_THET2
          Length = 412

 Score =  290 bits (741), Expect = 1e-76,   Method: Compositional matrix adjust.
 Identities = 172/413 (41%), Positives = 241/413 (58%), Gaps = 6/413 (1%)

Query: 14  AEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEI 73
           AE+ R    R  +S   ++   V  IL+ V+  GDEAL  +S   D   V   +V     
Sbjct: 5   AEEVRARFARRGLSFDPTVEEIVRGILEAVREEGDEALDRFSRDLDGYPVE--EVPKRAW 62

Query: 74  AAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPG 133
             A E L ++L+ A+  A + IE F+  +      +  + G    Q+ RP+  VG+Y+PG
Sbjct: 63  REAYEDLDEDLRDALETARERIEAFYREEARGGF-LRAEGGGVLAQLVRPLERVGVYVPG 121

Query: 134 GSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVFNVGGAQAIAAL 193
           GSAPL ST+LM   PA +AG ++V++ SPP +   +L AA + G   +F +GGAQAIAAL
Sbjct: 122 GSAPLLSTLLMTVVPAKVAGVREVIVASPPKVHPGVLAAAWVAGADRLFAMGGAQAIAAL 181

Query: 194 AFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVA 253
           A+GT  VP+VDKI GPGN +V  AKR V   +    ID  AGP+E ++IAD  A+P  +A
Sbjct: 182 AYGTGRVPRVDKIVGPGNRYVVAAKRLVYGTV---GIDGLAGPTETMIIADGSASPRLLA 238

Query: 254 SDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDL 313
           +DLL+QAEHGPDS+  LL+P   +  RV   + RQL +LPRAE ARQAL    L++TKDL
Sbjct: 239 ADLLAQAEHGPDSEPWLLSPDRALLERVEAELSRQLQDLPRAEVARQALEKGGLVLTKDL 298

Query: 314 AQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYG 373
            +   ++N Y PEHL +   +    ++ + +AG VFLG+ SPE+ GDY +G +HV+PT G
Sbjct: 299 EEAFALANLYAPEHLSLALSDPLPWLEKVQNAGGVFLGEGSPEALGDYIAGPSHVMPTSG 358

Query: 374 YTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
                  L + DF K + V  LS+     LA     LA AE L  H  ++ LR
Sbjct: 359 TARFQGGLAVRDFLKVIPVVGLSEGAARELAKKGALLARAEGLEGHARSLDLR 411


>UniRef50_Q4FQF8 Histidinol dehydrogenase n=6 Tax=Proteobacteria RepID=HISX_PSYA2
          Length = 431

 Score =  289 bits (740), Expect = 1e-76,   Method: Compositional matrix adjust.
 Identities = 171/405 (42%), Positives = 241/405 (59%), Gaps = 12/405 (2%)

Query: 31  SITRTVNDILDNVKARGDEALREYSAKFDK---TTVTALKVSAEEIAAASERLSDELKQA 87
           ++  TV+DI+  V+  GD  + E + +FD+   TT  AL++S E +A A   L D +K A
Sbjct: 28  TLLTTVDDIIARVRHGGDSVVLELTQQFDQHPATTTQALELSKEALAEAFANLDDVVKSA 87

Query: 88  MAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLAT 147
           +  A   ++TFH  Q       E + G R  Q    +  VG+Y+PGG A   S+VLM A 
Sbjct: 88  LITAATRVKTFHERQVQETWQYEDELGNRLGQKVTALDRVGIYVPGGLASYPSSVLMNAI 147

Query: 148 PASIAGCKKVVLCSPPP---IADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVD 204
           PA +AG K+V++  P P   +   +L AA L  V  VF +GGAQA+AALA+GTE++P VD
Sbjct: 148 PAKVAGVKEVIMVVPAPKGVLNPLVLAAAHLAKVDRVFTIGGAQAVAALAYGTETIPAVD 207

Query: 205 KIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGAT--PDFVASDLLSQAEH 262
           KI GPGN +V  AKR V  ++    IDM AGPSEVLV A+  A    D++A DLLSQAEH
Sbjct: 208 KITGPGNKYVAAAKRAVFGQV---GIDMIAGPSEVLVYAEGEAQDRADWLAMDLLSQAEH 264

Query: 263 GPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVEISN 321
              +Q I +T +A   + VA  +E+ LAELP+A+ AR +L N   LI+ +D  + + + N
Sbjct: 265 DRIAQAIFVTTSAQQLKEVAIEIEKALAELPKADIARDSLKNRGVLILVRDREEGMAVIN 324

Query: 322 QYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSL 381
           +  PEHL +   +   L++SI  AG++F+G  +PE+ GDY +G NHVLPT G     S L
Sbjct: 325 RVAPEHLELSVDHPDALLNSIRHAGAIFMGRHTPEAIGDYCAGPNHVLPTSGTARFSSPL 384

Query: 382 GLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
           G+ DFQK+ ++   S+ G   LA T + LA  E L AH  +   R
Sbjct: 385 GVYDFQKKSSIIYCSESGSKPLAQTADILAQHEDLEAHARSARYR 429


>UniRef50_B9KYT3 Histidinol dehydrogenase n=1 Tax=Thermomicrobium roseum DSM 5159
           RepID=B9KYT3_THERP
          Length = 448

 Score =  289 bits (739), Expect = 1e-76,   Method: Compositional matrix adjust.
 Identities = 163/400 (40%), Positives = 239/400 (59%), Gaps = 9/400 (2%)

Query: 34  RTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAMAVAVK 93
           + V  I+D+V+++GD+A+R Y+  FD   +     + EE   A   ++ EL+ A+  A  
Sbjct: 48  QVVERIIDDVRSQGDDAVRRYTLAFDGAHLDTFLATPEEFLRARRAITPELEAALRFARD 107

Query: 94  NIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAG 153
            I  FH  + +P   +E        Q+ RPV  VG+Y+PGG APL S++LM A PA +AG
Sbjct: 108 RIVAFHR-RAIPRSWIEFDETGAFGQLVRPVDRVGIYVPGGRAPLPSSLLMTAIPAQLAG 166

Query: 154 CKKVVLCSPP----PIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGP 209
            + +V+C+PP     I+  +L AA+L G++ VF +GGAQAIAALA+GT++VP VD + GP
Sbjct: 167 VRDIVVCTPPGRDGTISPAVLAAAELLGIERVFKIGGAQAIAALAYGTQTVPAVDIVAGP 226

Query: 210 GNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVI 269
           GN FV  AKR V        ID   GP+E L+IAD  A P   A+DLL+QAEH P +  I
Sbjct: 227 GNLFVVLAKRLV---YGDVGIDQLPGPTETLLIADEQADPVLCAADLLAQAEHDPLACAI 283

Query: 270 LLTPAADMARRVAEAVERQLAELPRAETARQALNAS-RLIVTKDLAQCVEISNQYGPEHL 328
           L+TPA  +A +VA+ +ERQL +L R+E AR AL A+  +I+  DL +  +++N + PEHL
Sbjct: 284 LITPARTLAHKVAQELERQLQQLDRSEIARAALEANGAIIIVPDLERAFDLANLFAPEHL 343

Query: 329 IIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQK 388
            +  R+    +D +  AG VFLG+ SPE  GDY +G +HV+PT       S + +  F K
Sbjct: 344 CLLVRDPWRYLDRVRHAGGVFLGETSPEVIGDYTAGPSHVMPTGRTARFASPVTVQTFLK 403

Query: 389 RMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVN 428
             ++  ++ +    L S    LA +E LTAH  A+  R+ 
Sbjct: 404 VTSLVAVAPKALEQLGSPALQLAMSEGLTAHAAAIEHRLE 443


>UniRef50_B9D1F9 Histidinol dehydrogenase n=2 Tax=Campylobacter RepID=B9D1F9_WOLRE
          Length = 431

 Score =  289 bits (739), Expect = 2e-76,   Method: Compositional matrix adjust.
 Identities = 162/408 (39%), Positives = 244/408 (59%), Gaps = 11/408 (2%)

Query: 31  SITRTVNDILDNVKARGDEALREYSAKFD--KTTVTALKVSAEEIAAASERLSDELKQAM 88
           ++T  V+ IL++V+ARGDEAL E   KFD  K    +LK+  EE+  A + +   L+ A+
Sbjct: 28  AVTPAVSQILEDVRARGDEALFEQIEKFDRWKPDTNSLKIGTEEMQKAYDGIDSCLRNAL 87

Query: 89  AVAVKNIETFHTAQKLPPVDVET-QPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLAT 147
            +A + I+++H  + LP   +E  + GV       P+   GLYIPGG A   S++LM A 
Sbjct: 88  NLAFERIKSYHE-KSLPKTWMEHDEHGVLLGAKYTPLDRAGLYIPGGKAAYPSSLLMNAV 146

Query: 148 PASIAGCKKVVLCSPP---PIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVD 204
           PA +AG  ++ +C+P     +   +L A  +CG+++ + VGGA A+AA+A+GT+++ K D
Sbjct: 147 PALVAGVGEIAVCTPAVGGKVNTLLLAAMHICGIKEAYKVGGASAVAAMAYGTQTIKKTD 206

Query: 205 KIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGP 264
            I GPGN +V  AK+ V   ++   IDM AGPSE+ VIAD  A P  +A DLLSQAEH  
Sbjct: 207 VITGPGNIYVATAKKLVYGEVN---IDMIAGPSEICVIADESADPRHIAVDLLSQAEHDE 263

Query: 265 DSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNA-SRLIVTKDLAQCVEISNQY 323
            +  +L+TP       V   +  ++  L R   A+ +++    +IV  DL +CV ++N+ 
Sbjct: 264 MASAVLITPNQAFGAAVQRHINEEIKTLARQPIAQASIDKKGAIIVASDLGECVRLANEL 323

Query: 324 GPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGL 383
            PEHL I T +A EL   I  AG++F+G ++PE+ GDY +G NH LPT G     S LG+
Sbjct: 324 APEHLEIATNDAMELARQIRHAGAIFIGHFTPEAMGDYLAGPNHTLPTGGSARFYSPLGV 383

Query: 384 ADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNALK 431
            +F KR ++  L+ +G S LA+    LA AE L AH+ +V +R+ ALK
Sbjct: 384 ENFMKRTSLISLNAKGISELANACMELAEAEGLGAHRRSVVVRLEALK 431


>UniRef50_Q01ZU1 Histidinol dehydrogenase n=1 Tax=Candidatus Solibacter usitatus
           Ellin6076 RepID=Q01ZU1_SOLUE
          Length = 423

 Score =  288 bits (736), Expect = 3e-76,   Method: Compositional matrix adjust.
 Identities = 168/411 (40%), Positives = 246/411 (59%), Gaps = 10/411 (2%)

Query: 19  QLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASE 78
            LL R A   +E+    V  IL+ V+ RGD AL +Y+ +FD+    +++V   E+ AA +
Sbjct: 12  HLLKRKAARFTEA-EAVVTPILEAVRKRGDRALMDYARQFDQLQRKSVRVPEGELLAARD 70

Query: 79  RLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPL 138
            L+ E + A+  A  NI  +   Q     +     G++  Q+ RP+ +V  YIP G  PL
Sbjct: 71  GLTPEFRGAIETAAPNIRAYAGRQMPREWNRSFGAGLQLGQLVRPLDAVAAYIPAGRYPL 130

Query: 139 FSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTE 198
            STV+M   PA +AG   + +  P P+A E+   A + GV++VF +GGAQAIAA AFGT 
Sbjct: 131 PSTVMMTVIPAQVAGVPNICIACPKPVA-EVYGTAAMLGVRNVFQMGGAQAIAAFAFGTR 189

Query: 199 SVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLS 258
           +VP+ D+I GPGN +V  AK+ ++  +    ID  AGP+E+L+IA  G  P   A+D+L+
Sbjct: 190 TVPRADRIVGPGNIYVAAAKKLLAGEV---GIDFIAGPTEILIIAADG-DPRHFAADMLA 245

Query: 259 QAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCV 317
           QAEH  D+  ILLT +  +A  V+  +ERQLA LP A  A +++   S +I+ + L + +
Sbjct: 246 QAEHDVDASAILLTTSKRLAAAVSRELERQLAILPTAPVASKSIAKNSAIILVRSLDEAL 305

Query: 318 EISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTAT 377
           EISN++ PEHL I   +   L+  +  AGSVF+G +SPE+AGDYASG NHVLPT G    
Sbjct: 306 EISNRFAPEHLSIPDAS---LLPGVRHAGSVFVGPYSPEAAGDYASGPNHVLPTSGAARQ 362

Query: 378 CSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVN 428
              L + D+ K ++VQ L++     LA +I TLA AE L AH  +V +R+ 
Sbjct: 363 RGGLSVTDYVKVISVQNLTEPALRRLAPSITTLARAEGLEAHARSVEVRLT 413


>UniRef50_B3DXR9 Histidinol dehydrogenase n=1 Tax=Methylacidiphilum infernorum V4
           RepID=B3DXR9_METI4
          Length = 426

 Score =  288 bits (736), Expect = 4e-76,   Method: Compositional matrix adjust.
 Identities = 149/422 (35%), Positives = 249/422 (59%), Gaps = 8/422 (1%)

Query: 6   IIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA 65
           I+ +     +Q+++ L R  + + E I +TV  +L+ +   GD+A+  Y+ +FDK +++ 
Sbjct: 8   ILRFGDLNWQQEKKGLSRFYLPSKE-IEQTVRRVLEEIIRNGDKAVSLYTEQFDKQSISP 66

Query: 66  LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVA 125
               A  I   + +   ++  A+  A +NI  F  A K     +  + G R  +   P  
Sbjct: 67  ---GAFRITEKAPQPPKDVVDALRWAKRNILCFAKANKPKNWSITNREGARVGEYYTPFR 123

Query: 126 SVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVFNVG 185
            +G+Y+PGG+APL ST LM    A  AG K++V+CSPPP+   + ++    G  +++ +G
Sbjct: 124 RIGVYVPGGTAPLISTALMTVCFAKAAGVKEIVVCSPPPVNPILHFSIIYSGATEIYRIG 183

Query: 186 GAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADS 245
           G QAI ALA+GTES+PKV+KIFGPGNA+V EAKRQV   +   +ID+  GPSE+ V A  
Sbjct: 184 GIQAIGALAYGTESIPKVEKIFGPGNAYVVEAKRQV---IGPVSIDLLPGPSEIAVFASW 240

Query: 246 GATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NA 304
            A P+F+A+DLL+QAEHGP S+++ ++P   +   V  A+ RQL  L R +  ++ L + 
Sbjct: 241 PANPEFIAADLLAQAEHGPSSKILFVSPENSLLESVIGAINRQLPSLKRQQILKEVLTDH 300

Query: 305 SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASG 364
           +  +  + + + + + N + PEHL +Q   A++ +    + G+++LG +S  +AGD+ +G
Sbjct: 301 AYFVQVRSIDEGIGLINDFAPEHLSLQIPGAKKYLAQFKNCGAIYLGPYSAVAAGDFLAG 360

Query: 365 TNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVT 424
            +H LPT G   + S L ++ F ++ +V E SK+    ++S +ET A  E L AH  ++T
Sbjct: 361 PSHTLPTGGAAKSFSGLTMSHFYRKTSVVEYSKKALCRVSSLLETFARIESLDAHGASIT 420

Query: 425 LR 426
           +R
Sbjct: 421 IR 422


>UniRef50_A9A0A6 Histidinol dehydrogenase n=2 Tax=Desulfobacteraceae
           RepID=A9A0A6_DESOH
          Length = 434

 Score =  287 bits (735), Expect = 5e-76,   Method: Compositional matrix adjust.
 Identities = 167/431 (38%), Positives = 250/431 (58%), Gaps = 15/431 (3%)

Query: 9   WNSCTAEQQRQL--LMRPAISASESITRTVNDILDNVKARGDEALREYSAKFD--KTTVT 64
           + S T E  R+L  ++   +  +      V  I+ +VK  GD+AL  Y+ +FD  K   +
Sbjct: 4   YTSGTPEADRRLDRIINRGLDYTPEQLHQVAAIVADVKKNGDKALERYTRQFDAPKLAAS 63

Query: 65  ALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPV 124
             +V+A E+A A++ +     +A+  A+  +  FH          E +PGV   +   PV
Sbjct: 64  GFRVTAAEMAGAAKEVDRSFVKAINRAIGQVSEFHAMGLEKTWTAEPRPGVVVGKKVTPV 123

Query: 125 ASVGLYIPG---GSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCG 177
            S G+Y+PG   G  PL STVLM A PA  AG +++V+ +PP     +   +L AA+  G
Sbjct: 124 DSAGIYVPGATGGRTPLVSTVLMGAIPAKTAGVRRIVMVTPPRQDGTVNPHLLVAAKKVG 183

Query: 178 VQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPS 237
           V +++ VG A AIAALA GT+++ +VD I GPGN +V  AK+ V+  +    IDM AGPS
Sbjct: 184 VHEIYKVGSAWAIAALAHGTKTIARVDMIAGPGNIYVALAKKIVAGTV---GIDMMAGPS 240

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAET 297
           E+LV+AD  A P ++A+DLLSQAEH   S  +L+T +  +AR V++ V+RQ   + R + 
Sbjct: 241 EILVVADGSADPRYIAADLLSQAEHDALSAAVLVTTSMKVARAVSDEVKRQTTGISRWQI 300

Query: 298 ARQALNA-SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPE 356
           AR+AL A   + V K   +   + N++ PEHL + T+N  + +D I +AG+VFLG ++PE
Sbjct: 301 ARKALAAYGAVFVVKSKKEAFALVNRFAPEHLELHTKNPEKDLDQIRNAGAVFLGPYTPE 360

Query: 357 SAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERL 416
             GDY +G NH LPT G     S+L  A F KR ++   SK  F + A+ +  +AA E L
Sbjct: 361 PIGDYVAGPNHTLPTSGCARFASALSTAHFLKRTSIVSYSKAAFLSEAADVMRIAAVEGL 420

Query: 417 TAHKNAVTLRV 427
            AH NAV +R+
Sbjct: 421 DAHANAVGVRL 431


>UniRef50_B1YL14 Histidinol dehydrogenase n=1 Tax=Exiguobacterium sibiricum 255-15
           RepID=B1YL14_EXIS2
          Length = 405

 Score =  287 bits (734), Expect = 7e-76,   Method: Compositional matrix adjust.
 Identities = 167/405 (41%), Positives = 240/405 (59%), Gaps = 8/405 (1%)

Query: 26  ISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELK 85
            S      + V  IL+ V   GD A+R Y+++FD+  +T  ++   +I  A ++    L 
Sbjct: 7   FSVDRETEQAVRSILEQVANDGDAAVRRYTSEFDRVDLTDFRLDETKIQEAFDQADPNLV 66

Query: 86  QAMAVAVKNIETFHTAQKLPPVDVE-TQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLM 144
            ++ +    +  +H  Q+LP  D+E  +  V  +Q   PV SVG+Y+PGG+A   STVLM
Sbjct: 67  DSLKLMATRLVEWHE-QELPS-DIELVEADVTRRQRFVPVDSVGIYVPGGAASYPSTVLM 124

Query: 145 LATPASIAGCKKVVLCSP-PPIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKV 203
            A PA +AG ++VV+ +P   ++ E+L AA++ GV +++ +GGAQA+AAL FGTES+  V
Sbjct: 125 NAIPAKVAGVERVVMVTPVTGLSMEVLVAAKIAGVTEIYTIGGAQAVAALTFGTESIQAV 184

Query: 204 DKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHG 263
           D I GPGN FV EAKRQV   +    ID  AGPSEV+VIAD  A PD +A+DLL+QAEH 
Sbjct: 185 DLIVGPGNRFVAEAKRQVYGIV---GIDSVAGPSEVVVIADETAHPDRIAADLLAQAEHD 241

Query: 264 PDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQCVEISNQY 323
            D+  I   P   M   V   +ER+L +LPR E AR+A+    + V   L   +E +N+ 
Sbjct: 242 RDAVAIAFVPTEAMKADVDANIERRLQQLPRQEIARRAMENGGVFVAS-LDDAIEEANRL 300

Query: 324 GPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGL 383
             EHL +   N +E+V  I  AG +FLG  +PE+ GDY +GTNHVLPT G     S L  
Sbjct: 301 AAEHLELAVANPQEVVKLIRHAGMIFLGHETPETLGDYVAGTNHVLPTSGTARFASGLSA 360

Query: 384 ADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVN 428
             F +  T+ E ++EG + LA+  +T+A  E L AH  A+ +R N
Sbjct: 361 RTFLRHQTMLEATREGVARLANAAKTVARVEGLEAHAQAIEVREN 405


>UniRef50_B3TCH3 Putative Histidinol dehydrogenase n=1 Tax=uncultured marine
           microorganism HF4000_APKG10K24 RepID=B3TCH3_9ZZZZ
          Length = 444

 Score =  287 bits (734), Expect = 7e-76,   Method: Compositional matrix adjust.
 Identities = 159/404 (39%), Positives = 243/404 (60%), Gaps = 11/404 (2%)

Query: 34  RTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAMAVAVK 93
           ++V  +L +V+  GD A+R YS   D   +++ KV  E++A A+  +S EL++++ +A +
Sbjct: 43  QSVLKMLQDVRQDGDAAVRRYSKLLDGVELSSFKVEKEQLAQAAASVSTELRESLELAAE 102

Query: 94  NIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAG 153
            I  FH  Q + P D   + G    Q+ RP+  VGLY PGG+A   STVLM A PA +AG
Sbjct: 103 RIRQFH--QAVMPKDWLDEEG-GLGQLVRPLERVGLYAPGGTAAYPSTVLMTAIPARVAG 159

Query: 154 CKKVVLCSP----PPIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGP 209
             +V+LC+P      +   +L AA++ GV  V+ +GG  AI A+A+GT+SVPKVDKI GP
Sbjct: 160 VNEVILCTPARPGEALNPAVLVAAEISGVDTVYQIGGVPAIGAMAYGTDSVPKVDKICGP 219

Query: 210 GNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVI 269
           GN FV  AK+ V  ++D   ID   GP+E +VIAD  A P F A+DL+ QAEH P +  I
Sbjct: 220 GNVFVAYAKKLVQGQVD---IDGVFGPTETVVIADESADPGFCAADLIGQAEHDPLATAI 276

Query: 270 LLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVEISNQYGPEHL 328
           L+T + D+  RV   ++ QL    R + ARQAL    R+++ + +A+ VE++++  PEH+
Sbjct: 277 LITDSQDLIDRVERELDEQLNIQLRGDLARQALERQGRIVLVESVAEAVELADRIAPEHM 336

Query: 329 IIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQK 388
            +  ++  +   ++  AG +FLG++SPE  GDY +G +HV+PT G     S+L +  F +
Sbjct: 337 CLMVQDPWKWAGTVKHAGGLFLGEYSPEVMGDYVAGPSHVMPTGGTARFSSALSVHQFLR 396

Query: 389 RMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNALKE 432
            M V  LS + F  L      +A AE L  H  AV +R++ L++
Sbjct: 397 TMPVVSLSADDFQKLGPAAIEIAKAEGLDGHATAVRMRLDKLQK 440


>UniRef50_C4V2I6 Histidinol dehydrogenase n=1 Tax=Selenomonas flueggei ATCC 43531
           RepID=C4V2I6_9FIRM
          Length = 448

 Score =  286 bits (731), Expect = 2e-75,   Method: Compositional matrix adjust.
 Identities = 163/397 (41%), Positives = 242/397 (60%), Gaps = 9/397 (2%)

Query: 36  VNDILDNVKARGDEALREYSAKFDKTTV--TALKVSAEEIAAASERLSDELKQAMAVAVK 93
           V+ I+ +V++ GD+AL  Y+   D   +  T + VS  E+ AA+++    +  ++  A K
Sbjct: 50  VHHIVRDVRSGGDQALLRYTKLLDGLDLSSTDIMVSESELQAAADQADAAVLASLERAAK 109

Query: 94  NIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAG 153
           NI  FH  QK          G    Q   P++ VG+Y+PGG+A   S+VLM A PA +AG
Sbjct: 110 NIFAFHEEQKPKSWMTYRAHGSILGQEVIPLSRVGIYVPGGTAAYPSSVLMNAIPAIVAG 169

Query: 154 CKKVVLCSPPP---IADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPG 210
              +++  P     +   +L AA + G++ +F VGGAQAIAA+A+GTES+P+VDKI GPG
Sbjct: 170 VDDIIMSVPTKGGVLNPYVLAAAHMLGIKKIFRVGGAQAIAAMAYGTESIPRVDKITGPG 229

Query: 211 NAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVIL 270
           N FVT AK++V   +D   IDM AGPSE+L++AD  A+P ++A+D+LSQAEH P +  IL
Sbjct: 230 NLFVTLAKKEVYGYVD---IDMLAGPSEILILADEEASPKYIAADMLSQAEHDPLASSIL 286

Query: 271 LTPAADMARRVAEAVERQLAELPRAETARQALNAS-RLIVTKDLAQCVEISNQYGPEHLI 329
           +T +AD+A  V   ++ QL  LPR ETA  +L  + R+IVT+++ Q V ++N  GPEH+ 
Sbjct: 287 ITDSADLASNVRCEIQDQLQSLPRMETASASLERNGRIIVTENIQQSVHLANYSGPEHIE 346

Query: 330 IQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKR 389
           +  ++A  L+  I  AG+VF+G +SPE  GDY +G NHVLPT G     S L +  F KR
Sbjct: 347 LLVKDAFHLLPEIRCAGAVFVGSYSPEPLGDYFAGPNHVLPTGGTARFYSVLNVETFMKR 406

Query: 390 MTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
            ++   +++    ++  I  LA  E L AH  A+  R
Sbjct: 407 TSIISYTRKALDEVSDDIIRLAETEGLEAHARAIRTR 443


>UniRef50_Q3J079 Histidinol dehydrogenase 1 n=26 Tax=Proteobacteria
           RepID=HISX1_RHOS4
          Length = 434

 Score =  284 bits (726), Expect = 5e-75,   Method: Compositional matrix adjust.
 Identities = 169/410 (41%), Positives = 236/410 (57%), Gaps = 9/410 (2%)

Query: 29  SESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA--LKVSAEEIAAASERLSDELKQ 86
           S  +   V  I+ +V+ARGD A+ E +A+FD+  +T   L  S  EI A    +S E + 
Sbjct: 27  SPDVDAVVAGIIADVRARGDAAVIELTARFDRLELTPERLAFSEAEIEAEIATVSAEDRA 86

Query: 87  AMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLA 146
           A+ +A + I  +H  Q           G        P+AS GLY+PGG A   S+VLM A
Sbjct: 87  ALELAAERIRAYHARQMPENARWTDAAGAELGWRWGPIASAGLYVPGGLASYPSSVLMNA 146

Query: 147 TPASIAGCKKVVLCSPPP---IADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKV 203
            PA +AG +++V+  P P   +   +L AA+L GV  V+ +GGAQA+AALA+GTE++  V
Sbjct: 147 IPARVAGVERLVVACPTPGGVVNPLVLLAARLAGVDAVYRIGGAQAVAALAYGTETIRPV 206

Query: 204 DKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHG 263
           DKI GPGNA+V  AKR+V  R+    IDM AGPSE+LVIA+    PD++A DLLSQAEH 
Sbjct: 207 DKITGPGNAYVAAAKRRVFGRV---GIDMIAGPSEILVIAEGAVDPDWIALDLLSQAEHD 263

Query: 264 PDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVEISNQ 322
             +Q IL+TP   + R V +AVE +L  L R   A  +  +   +IVT+DL +   +S++
Sbjct: 264 ESAQSILVTPDEALGRAVVQAVEARLETLERRAIAGASWRDYGAVIVTRDLEEAAALSDR 323

Query: 323 YGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLG 382
             PEHL +   +   L   I  AG++FLG W+PE+ GDY  G NHVLPT       S L 
Sbjct: 324 VAPEHLELCVADPEALAARIRHAGAIFLGGWTPEAIGDYVGGPNHVLPTARSARFSSGLS 383

Query: 383 LADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNALKE 432
           + DF KR T+  ++     A+    E LA +E L AH  +V  R++ L E
Sbjct: 384 VMDFLKRTTLARMTPAALRAVGPAAERLAISESLEAHGLSVRARLDRLNE 433


>UniRef50_P62457 Histidinol dehydrogenase n=27 Tax=cellular organisms
           RepID=HISX_DESVH
          Length = 436

 Score =  283 bits (724), Expect = 9e-75,   Method: Compositional matrix adjust.
 Identities = 171/407 (42%), Positives = 234/407 (57%), Gaps = 13/407 (3%)

Query: 30  ESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA--LKVSAEEIAAASERLSDELKQA 87
           +++   V DIL  V+++GDEAL EY+ +FD    T   L V++EE+A A   +  +    
Sbjct: 29  DAVEPVVRDILAAVRSKGDEALAEYTRRFDCPDFTPALLHVTSEEVAQAVASVPADDIAI 88

Query: 88  MAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSA---PLFSTVLM 144
           +  A  NI +FH AQK     V    G    Q   PV   GLY+PGG     PL S++LM
Sbjct: 89  IRQAADNIRSFHEAQKERSWFVTHDDGTILGQKVTPVDRAGLYVPGGKGGDTPLLSSLLM 148

Query: 145 LATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESV 200
            A PA +AG   + + SPP     +   +L AA + G+ D+   G A A+AA AFGT+++
Sbjct: 149 NAIPAQVAGVTSITVASPPRPDGTLNPHLLAAAHILGITDIIRAGSAWAVAAFAFGTQTI 208

Query: 201 PKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQA 260
             VD I GPGN FVT AKR V  R+   AIDM AGPSE+L++AD+ A PD+VA+D+LSQA
Sbjct: 209 APVDVIAGPGNIFVTTAKRMVQGRV---AIDMIAGPSEILILADATARPDWVAADMLSQA 265

Query: 261 EHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVEI 319
           EH P +  IL+T    +A  V   +ERQLA LPRA+ AR+AL +   ++V  D+   V I
Sbjct: 266 EHDPLASSILVTTEPALAEAVTAELERQLATLPRADIARKALADWGAVVVVPDMDVAVAI 325

Query: 320 SNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCS 379
           +N+  PEHL + T    EL  S+  AG++FLG +SPE  GDY +G NHVLPT G     S
Sbjct: 326 ANRVAPEHLEVLTAQPWELAGSLRHAGALFLGPYSPEPLGDYFAGPNHVLPTMGTARFSS 385

Query: 380 SLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
           +L +  F KR ++   S+      A  +  LA  E L AH  +   R
Sbjct: 386 ALSVQTFCKRTSIIAASRAFAERNADAVARLARLEGLEAHARSAASR 432


>UniRef50_C8WUX6 Histidinol dehydrogenase n=2 Tax=Alicyclobacillus acidocaldarius
           RepID=C8WUX6_ALIAD
          Length = 426

 Score =  283 bits (723), Expect = 1e-74,   Method: Compositional matrix adjust.
 Identities = 170/401 (42%), Positives = 240/401 (59%), Gaps = 9/401 (2%)

Query: 36  VNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAMAVAVKNI 95
           V  I++ V+  GD+ALR  +   D      L+V  E + AA   L  E+++A+A A + I
Sbjct: 30  VERIVEEVRVGGDDALRRLTRALDGVD-APLRVPPEAMEAAFRALRAEVREALARAAERI 88

Query: 96  ETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCK 155
             FH AQ    + +  + G   + + RP+  VG+Y PGG A   STVLM   PA +AG +
Sbjct: 89  RRFHEAQLPNDIVIRGEDGETLEMLWRPLHRVGVYAPGGRAAYPSTVLMDVIPAQVAGVR 148

Query: 156 KVVLCSPP-PIA---DEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGN 211
            + L SPP P       +L AA L GV++++ VGGAQA+AALA+GTE++ +VDKI GPGN
Sbjct: 149 SIALVSPPGPDGLPHPAVLAAAHLVGVEEMYAVGGAQAVAALAYGTETIARVDKIVGPGN 208

Query: 212 AFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILL 271
            +V  AKR V   +    ID  AGP+EV+V+AD  A P +VA+DLL+QAEH  ++  + L
Sbjct: 209 VYVATAKRMV---MGDVGIDSIAGPTEVVVVADETANPAYVAADLLAQAEHDVEAGAVCL 265

Query: 272 TPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVEISNQYGPEHLII 330
           +P+ ++   V   + RQLA LPR + AR+AL     L+  K L   V + N   PEH+ +
Sbjct: 266 SPSRELLENVHAEIVRQLAALPRRDIAREALERHGALVHVKSLDDAVVLVNDMAPEHVEV 325

Query: 331 QTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRM 390
            T N R +++ + +AG+VFLG ++PE  GDY +GTNHVLPT+G     S LG  DF +RM
Sbjct: 326 VTENPRRVLNGLRTAGAVFLGPYTPEPVGDYFAGTNHVLPTHGSARFSSGLGTLDFMRRM 385

Query: 391 TVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNALK 431
           T    + E  +  A  IE LA AE LTAH+ AV +R   L+
Sbjct: 386 TAATYTAETIARHAPYIEALAEAESLTAHREAVRIRREELR 426


>UniRef50_D0RRH1 Histidinol dehydrogenase n=1 Tax=alpha proteobacterium HIMB114
           RepID=D0RRH1_9RICK
          Length = 429

 Score =  283 bits (723), Expect = 1e-74,   Method: Compositional matrix adjust.
 Identities = 158/406 (38%), Positives = 236/406 (58%), Gaps = 11/406 (2%)

Query: 29  SESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDEL--KQ 86
           S +  + V  I+ ++K  GD AL +Y+ +FDK      K+  ++   + +    ++  K+
Sbjct: 26  SNNSQKIVKKIISDIKKNGDLALIKYTKRFDKVNFGPSKIKLDDKLISKKIKKLDINIKK 85

Query: 87  AMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLA 146
           ++ +A   I  FH  Q       + + G +      P+  VG+Y+PGG+A   ST+LM +
Sbjct: 86  SIDLAFNRITKFHKKQVHKGFKFKDKLGNQLGYKILPLDKVGVYVPGGTASYPSTLLMNS 145

Query: 147 TPASIAGCKKVVLCSPPPIADEI----LYAAQLCGVQDVFNVGGAQAIAALAFGTESVPK 202
            PA +AG K +    P P  DEI    LYAA+ C ++ +F +GGAQA+AAL +GT++VPK
Sbjct: 146 IPAMVAGVKNIYCVMPTP-KDEINAGVLYAAKKCKIKSIFRIGGAQAVAALTYGTKNVPK 204

Query: 203 VDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEH 262
           VDKI GPGN FV  AK++V        IDM AGPSE+ VIAD     D+ A DLLSQAEH
Sbjct: 205 VDKIVGPGNIFVATAKKEV---FGTVGIDMVAGPSEITVIADDRNRADWTAVDLLSQAEH 261

Query: 263 GPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVEISN 321
              SQ ILLT +   A++V+  V++ L  LPR + A +++ N   ++V K+  + V+ +N
Sbjct: 262 DVLSQSILLTTSEKFAKQVSLEVKKILKTLPRKKIASKSIKNYGCIVVCKNKKELVDYAN 321

Query: 322 QYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSL 381
              PEHL I+ + + +L   I +AGS+FLG++SPE+ GDY +G NHVLPT G     S L
Sbjct: 322 IIAPEHLEIKIKGSEKLEKQIKNAGSIFLGEFSPEAIGDYLAGPNHVLPTSGSARFASGL 381

Query: 382 GLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRV 427
            + DF KR ++ + +K G   +      LA  E L AH  +V+ R+
Sbjct: 382 SVNDFLKRTSLIKCTKRGIEKIGQMAINLANYEGLHAHALSVSKRI 427


>UniRef50_C9LTV1 Histidinol dehydrogenase n=1 Tax=Selenomonas sputigena ATCC 35185
           RepID=C9LTV1_9FIRM
          Length = 449

 Score =  281 bits (718), Expect = 4e-74,   Method: Compositional matrix adjust.
 Identities = 163/413 (39%), Positives = 238/413 (57%), Gaps = 13/413 (3%)

Query: 26  ISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA--LKVSAEEIAAASERLSDE 83
           ++A+E   R V D    V+  GDEA+ +Y+   D T  +    +VS EE A A +     
Sbjct: 44  LTAAEVAVRIVED----VRRHGDEAVIKYTKLIDGTDFSPEDFQVSEEEFAEAEKNADPA 99

Query: 84  LKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVL 143
           +  ++  A  N+ ++H  QK        + G    Q   P+   G+Y+PGG+A   S+VL
Sbjct: 100 IVASLQRAAHNVRSYHEEQKANSWLTYREKGSILGQSLIPLDRAGIYVPGGTAAYPSSVL 159

Query: 144 MLATPASIAGCKKVVLCSPPP---IADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESV 200
           M A PA++AG  ++++  PP    I   +L AA++ GV  V+ +GGAQAIAA+A+GT ++
Sbjct: 160 MNAVPAAVAGVGEIIMMVPPKNGKINPYVLLAAKIAGVSKVYKIGGAQAIAAMAYGTATI 219

Query: 201 PKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQA 260
           P+VDKI GPGN FVT AK+ V    D   IDM AGPSE+L++AD  A P + A+D+LSQA
Sbjct: 220 PRVDKITGPGNIFVTLAKKAVYGHCD---IDMLAGPSEILIVADETADPAYTAADMLSQA 276

Query: 261 EHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVEI 319
           EH   +  IL+T +A +A  V   +E QL  LPR   AR ++ N   +++  D+ + +E 
Sbjct: 277 EHDTLASSILITTSAKLAHEVEALLEEQLKGLPRENIARASIENNGLIVIADDIMEALEY 336

Query: 320 SNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCS 379
           +N   PEH+ + T+   EL+  +  AG+VFLG +SPE  GDY +G NHVLPT G     S
Sbjct: 337 ANISAPEHMELLTKQPFELLPYVRHAGAVFLGAYSPEPLGDYFAGPNHVLPTGGTARFYS 396

Query: 380 SLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNALKE 432
            L +  F KR ++   +K+    + + I  LA AE L AH NAV LR    K+
Sbjct: 397 VLNVETFMKRTSIISYTKDALHDVEADIIRLAEAEGLHAHANAVRLRSKERKD 449


>UniRef50_P73058 Histidinol dehydrogenase 1 n=11 Tax=Cyanobacteria RepID=HISX1_SYNY3
          Length = 434

 Score =  280 bits (717), Expect = 5e-74,   Method: Compositional matrix adjust.
 Identities = 163/435 (37%), Positives = 251/435 (57%), Gaps = 14/435 (3%)

Query: 6   IIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA 65
           I+  +  T +Q  QL  R   +  +++     ++++ VK  GD  +  YS +FD    TA
Sbjct: 4   ILKLSHLTPQQLNQLKRRSEQNIDQALA-IAKEVIEQVKMEGDAGVLHYSRQFDFAGATA 62

Query: 66  --LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDV-ETQPGVRCQQVTR 122
             L+VS  E A A + +  EL++A+  A +NIE  H  Q  PP+ + E +PGV   +   
Sbjct: 63  ENLRVSEAEFAEAEKLVDPELRRAVEHAFRNIEKVHAGQMPPPMHLAEIEPGVFAGEKIT 122

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEI----LYAAQLCGV 178
           P+ +VGLY+P G     S +LMLA PA +AG KK+V+C+PP    ++    L  A++ GV
Sbjct: 123 PLPTVGLYVPRGKGAFPSMMLMLAVPARVAGVKKIVVCTPPDKEGKVEPVSLVTARMAGV 182

Query: 179 QDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSE 238
            +V+ +GG QA+AA+A+GT++V KVDK+ GP + +   AKR +S  +D   + +PAGPSE
Sbjct: 183 DEVYKLGGVQALAAIAYGTKTVSKVDKLIGPCSIYGAAAKRLLSGIVD---VGLPAGPSE 239

Query: 239 VLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELP--RAE 296
            +V+AD    P   A DLL +AEHG DS  +L+T +A +A +    +   L +LP  R +
Sbjct: 240 SIVLADETTDPKLAALDLLIEAEHGSDSAALLVTHSASLAEKALGYLGEYLEKLPPWRKK 299

Query: 297 TARQALNA-SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSP 355
                L +   +++T  L   ++  N Y PEHL + T +  +LV  I +AG + LG+++P
Sbjct: 300 FCEDGLGSYGGILLTDSLQASLDFINDYAPEHLQVLTADPLKLVGKIDNAGEILLGNYTP 359

Query: 356 ESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAER 415
            SA  YA G N VLPT G+  + S++ + DF KR T+  L++EGF+ +  T+ TLA  E 
Sbjct: 360 SSAATYAIGVNAVLPTGGFARSYSAVSVFDFLKRSTLAYLTEEGFAGVKETVTTLADYED 419

Query: 416 LTAHKNAVTLRVNAL 430
             AH  A+  R N L
Sbjct: 420 FPAHALAIRERENLL 434


>UniRef50_Q9X0D1 Histidinol dehydrogenase n=6 Tax=Thermotogaceae RepID=HISX_THEMA
          Length = 428

 Score =  280 bits (716), Expect = 7e-74,   Method: Compositional matrix adjust.
 Identities = 151/419 (36%), Positives = 243/419 (57%), Gaps = 14/419 (3%)

Query: 21  LMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDK--TTVTALKVSAEEIAAASE 78
           L++  + +   +  TV +I+  VK  GD AL E+  +F+K    +  L+V+ +EI+ A  
Sbjct: 15  LLKQRMESVSQVEETVKEIIRRVKEEGDRALEEFLKRFEKHPVGIENLRVTEKEISEA-- 72

Query: 79  RLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPL 138
           ++ +E  + + + +++++ FH  Q+       T+ G    ++  P+ SVG+Y+PGG  P 
Sbjct: 73  QVEEEFVETIKIVIEDLKEFHRRQEERSFFFTTKGGSFLGEMVVPLESVGIYVPGGKVPY 132

Query: 139 FSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQDVFNVGGAQAIAALA 194
           FST+LM A PA +AG +++ + +PP     I+  IL   ++ G+++++ +GGA A+AAL 
Sbjct: 133 FSTLLMCAVPAIVAGVERIAVTTPPNENGGISPYILKTCEILGLKEIYRMGGAHAVAALT 192

Query: 195 FGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVAS 254
           +GTE+V  VDKI GPG  FVT AK+ V        ID  AGPSE+ ++ D  A  D +A+
Sbjct: 193 YGTETVKPVDKIVGPGGVFVTLAKKHV---YGDVGIDSIAGPSEIAIVTDGSADLDLIAA 249

Query: 255 DLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELP--RAETARQAL-NASRLIVTK 311
           D LSQAEH  ++  +++T + ++  ++ + +ER L  LP  R +TAR +  N   +I+T 
Sbjct: 250 DFLSQAEHDENAMSVVITTSKEVFEKLPQVIERHLEALPEERRKTARISTENFGTIILTD 309

Query: 312 DLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPT 371
            L +  EISN   PEHL +   N  E +  I +AGSVFLG ++ ES GDY +G NHVLPT
Sbjct: 310 SLKRAFEISNLIAPEHLEVLVENPFEPLGHIKNAGSVFLGKYTCESVGDYGAGPNHVLPT 369

Query: 372 YGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNAL 430
           +      S L ++DF K++ +  LS+E F   +     +A  E   AH  A+ +R   L
Sbjct: 370 FRSARFSSGLRVSDFTKKIFITHLSEEDFRRKSELYSKMARWEGFEAHARAIDVRREKL 428


>UniRef50_Q0AP81 Histidinol dehydrogenase, Histidinol-phosphatase n=10 Tax=Bacteria
           RepID=Q0AP81_MARMM
          Length = 631

 Score =  280 bits (716), Expect = 8e-74,   Method: Compositional matrix adjust.
 Identities = 186/425 (43%), Positives = 258/425 (60%), Gaps = 6/425 (1%)

Query: 6   IIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA 65
           I++W   + E + + L R   ++S S      DI+D ++ +GDEA+R Y+ + D      
Sbjct: 4   ILNWTDASPEARTRALTR--PASSSSAGPAARDIVDAIRDQGDEAVRAYAKRLDGYAPGD 61

Query: 66  LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVA 125
            +V    + AA   L     +A+  A   +  FH  Q      VET PGV   +   PV 
Sbjct: 62  FRVPEGVLKAARAALDPRDAEAIKAAADAVRRFHVQQGYRGYSVETWPGVTASRRATPVD 121

Query: 126 SVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQDV 181
           +  LY+P GSAPL S+++MLA PA +AG  ++V+ +PP     +   +L AA L G+ +V
Sbjct: 122 TAALYVPAGSAPLVSSLIMLAIPAQLAGVPRIVVVAPPAGDGGVNPALLAAADLLGLDEV 181

Query: 182 FNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLV 241
           + +GGAQAIAAL+FG   +P+ DKIFGPGNA+V  AK  VS    G A+D+PAGPSEV+V
Sbjct: 182 YAIGGAQAIAALSFGAAGLPRADKIFGPGNAYVAAAKAYVSSLPGGPAVDLPAGPSEVMV 241

Query: 242 IADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQA 301
           IAD  A PD VASDLLSQAEH P +QV+L+   A  A RV  +V + L +LPRA  AR+A
Sbjct: 242 IADETADPDLVASDLLSQAEHDPSAQVMLVCFDAATADRVTASVAKLLEDLPRAAIAREA 301

Query: 302 LNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDY 361
           L AS ++V   +   ++I+N Y PEHLI+Q  +A  L+  +  AGS+F+G W+PE+AGDY
Sbjct: 302 LAASAILVCDSVDDAIDIANIYAPEHLILQAESAERLLAGVRHAGSIFVGAWTPEAAGDY 361

Query: 362 ASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKN 421
           A+G NH LPT G       + +  FQK  T+   S+ G  ALA T+E LAA E+L AH  
Sbjct: 362 AAGPNHTLPTAGAARAHGGVSVESFQKTTTILRASEAGAVALAPTVERLAALEQLDAHGL 421

Query: 422 AVTLR 426
           A+ LR
Sbjct: 422 AMRLR 426


>UniRef50_C9RN89 Histidinol dehydrogenase n=1 Tax=Fibrobacter succinogenes subsp.
           succinogenes S85 RepID=C9RN89_FIBSS
          Length = 429

 Score =  280 bits (715), Expect = 9e-74,   Method: Compositional matrix adjust.
 Identities = 169/414 (40%), Positives = 237/414 (57%), Gaps = 17/414 (4%)

Query: 26  ISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELK 85
           ++ S+ I   V DIL ++K  G     EY+ KFD      L+VS  EI  ++ +   E++
Sbjct: 21  VAPSKEIHDKVMDILADIKNGGYAKAVEYAQKFDGLKGKNLRVSEAEIKKSAAKCPPEMQ 80

Query: 86  QAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLML 145
           +A+  A+KN+  FH  Q      +E + GV   Q  RP+  VGLY+PGG+    STV+M 
Sbjct: 81  RALKQAIKNVRDFHVNQMEDSWLMEGKDGVVLGQRIRPMKRVGLYVPGGAGIYPSTVIMN 140

Query: 146 ATPASIAGCKKVVLCSPPPIADEILYAAQ--LC--GVQDVFNVGGAQAIAALAFGTES-- 199
           A PA +AG K +V+ +P  I  EI  A    LC  G+ +V+++GGAQAI  LA+G +   
Sbjct: 141 AVPAIVAGVKDIVVVTP--IKGEINRAVAFVLCELGITEVYHIGGAQAIGMLAYGAKDGK 198

Query: 200 ----VPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASD 255
               V +VDKI GPGN F   AK++V   +D   IDM AGPSEVLV+AD+   PDFVA+D
Sbjct: 199 GKVVVERVDKIVGPGNVFAAVAKKEVFGIVD---IDMVAGPSEVLVLADNTCDPDFVAAD 255

Query: 256 LLSQAEHGPDSQV-ILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDL 313
           LLSQAEHG   +  I +T   + A+ ++E V+ Q+   P+ E  ++ L N  R++V KD 
Sbjct: 256 LLSQAEHGSGFEAAICITDNMETAQMISECVDIQVENSPKRELLQKVLDNFGRILVVKDW 315

Query: 314 AQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYG 373
              V I+N   PEH+ I T  A  +   I +AG+VF+G WS E  GDY +G NHVLPT G
Sbjct: 316 FDGVAIANAIAPEHMEIMTDEAESMAAQIENAGAVFIGPWSSEPVGDYFAGPNHVLPTNG 375

Query: 374 YTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRV 427
                S LG+ DF KRM++ + S++     A  I  +A  E    H  AV  R+
Sbjct: 376 TGRFFSPLGVYDFLKRMSIIKYSEKAIKKNAKAIAVVANEEGFIHHAAAVLKRL 429


>UniRef50_Q8TXG3 Histidinol dehydrogenase n=1 Tax=Methanopyrus kandleri
           RepID=HISX_METKA
          Length = 431

 Score =  277 bits (709), Expect = 5e-73,   Method: Compositional matrix adjust.
 Identities = 177/402 (44%), Positives = 236/402 (58%), Gaps = 13/402 (3%)

Query: 36  VNDILDNVKARGDEALREYSAKFDKTTVTA--LKVSAEEIAAASERLSDELKQAMAVAVK 93
           V  I ++V  RGDEAL EY+ +FD   + A  L+VS ++   A E + +   +A+  A  
Sbjct: 30  VERIFEDVVERGDEALLEYTERFDGVKLEAEDLRVSEDDFEVARELVDERTVEALEEAAH 89

Query: 94  NIETFHTAQKLPPVDVET--QPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASI 151
            IE FH  + LP VD  T    G  C    RP+  VG Y+PGG A   ST LM   PA +
Sbjct: 90  RIEEFHR-KTLPRVDRITFDVEGTECGLTLRPIPRVGCYVPGGRAAYPSTALMTVIPARV 148

Query: 152 AGCKKVVLCSPPPIAD-----EILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKI 206
           AGC++VV+C+PP   D     E+L A ++ G   V+ VGGAQAIAALA GTE+V +VDKI
Sbjct: 149 AGCREVVVCTPPADNDVRASPEVLVAVEIAGADAVYRVGGAQAIAALAAGTETVLRVDKI 208

Query: 207 FGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDS 266
            GPGN +VT AK     R     +DMPAGPSEV VIAD  A PD++A DL++QAEH P +
Sbjct: 209 VGPGNVYVTAAKLLAYSR-GLTDVDMPAGPSEVFVIADDSANPDWLARDLIAQAEHDPHA 267

Query: 267 QVILLTPAADMARRVAEAVERQL-AELPRAETARQALNASRLIVTKD-LAQCVEISNQYG 324
             +L T + ++AR V E VE  L A + R E   +AL+ +  IV  D L +CV ++N+Y 
Sbjct: 268 AAVLATDSEEIARAVKERVEELLDAGIEREEIVLKALDRNGWIVVLDSLEECVRLANRYA 327

Query: 325 PEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLA 384
           PEHL +   N  EL+  + +AG+VF+G  +    GDYA+G NHVLPT G+     +LG  
Sbjct: 328 PEHLQLCVENPEELLQDVENAGAVFVGHLTAVPFGDYATGPNHVLPTGGFARARGALGTW 387

Query: 385 DFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
           DF K + +Q L +     LA  +E LA  E L  H  AV  R
Sbjct: 388 DFVKIIPIQRLREGDVERLAPIVEELAEREGLPNHAEAVRAR 429


>UniRef50_D1N997 Histidinol dehydrogenase n=2 Tax=Lentisphaerae RepID=D1N997_9BACT
          Length = 431

 Score =  275 bits (704), Expect = 2e-72,   Method: Compositional matrix adjust.
 Identities = 165/397 (41%), Positives = 228/397 (57%), Gaps = 11/397 (2%)

Query: 42  NVKARGDEALREYSAKFDKTTVTA--LKVSAEEIAAASERLSDELKQAMAVAVKNIETFH 99
           +VKA GD AL  Y+AKFD   +T    +V+ +EIAAA ++L   LK A+  A++ +  F 
Sbjct: 38  DVKAEGDAALVRYAAKFDHAELTPAQFRVTGDEIAAAEKQLPARLKSAIRTALRQVRDFA 97

Query: 100 TAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVL 159
                       +PGV   +   P+  VG+YIPGG+APL STVL  A  A  A  K++V 
Sbjct: 98  KLTIPKGWTASPRPGVTLGEKFEPLDRVGVYIPGGTAPLVSTVLHTAGIAGAAKVKEIVA 157

Query: 160 CSPP----PIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVT 215
            +PP     +   +LYA +L GV +++ +GG   +AALA GTE++ KV+KI GPGNA+VT
Sbjct: 158 VTPPGRDGKVHPAVLYAMKLAGVTEIYRLGGVYGVAALACGTETIAKVEKIVGPGNAYVT 217

Query: 216 EAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPD-SQVILLTPA 274
            AK+ +  ++   AIDM AGPSE+LVIAD  A P F+A+DLLSQAEHG    Q +L+T  
Sbjct: 218 AAKKLLYGQV---AIDMVAGPSEILVIADETADPSFIAADLLSQAEHGSGLEQAVLVTTD 274

Query: 275 ADMARRVAEAVERQLAELPRAETA-RQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTR 333
             M  RV     RQ A LPR  T  R   +   LI T DL     I++ Y PEHL IQT 
Sbjct: 275 KAMIDRVEAEFLRQKATLPRLATVDRVQEHGLFLIHTPDLDTAAAIASSYAPEHLEIQTA 334

Query: 334 NARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQ 393
              ++   IT+AG++FLG W+PE  GD+ +G +HVLPT       + L    F +R ++ 
Sbjct: 335 RPEQVARKITAAGAMFLGKWTPEPVGDFCAGPSHVLPTASSARYFNGLETVSFFRRSSIV 394

Query: 394 ELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNAL 430
           + ++       S +E  A  E L AH  + T+RV  L
Sbjct: 395 KYTEAAIRREVSMVEAFAEMEGLAAHGRSGTIRVKPL 431


>UniRef50_Q3ZXL7 Histidinol dehydrogenase n=5 Tax=Dehalococcoides RepID=HISX_DEHSC
          Length = 436

 Score =  275 bits (704), Expect = 2e-72,   Method: Compositional matrix adjust.
 Identities = 158/399 (39%), Positives = 237/399 (59%), Gaps = 10/399 (2%)

Query: 34  RTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAMAVAVK 93
           + VN I+ +V+ +GDEA+  Y+ KFD+  ++ L+V   EI  A+  +  EL +A+ +A  
Sbjct: 42  KAVNGIIADVRKQGDEAVLGYTLKFDRANLSKLEVGQPEIQQAASEIPAELFEALQLAAS 101

Query: 94  NIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAG 153
            I  +H  QK      +T   ++ +Q+ RP+  VGLY+PGG A   STVLM A PA  AG
Sbjct: 102 QIRAYHRFQK--EAVWKTAEIMQGKQLIRPLERVGLYVPGGKAFYPSTVLMTAIPAREAG 159

Query: 154 CKKVVLCSPPPIADEI----LYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGP 209
            K+++L +PP    +I    L AAQ+ GV  +F  GGAQA+AALAFGT+S+PKVDKI GP
Sbjct: 160 VKEIILVTPPGANGKIPAPTLAAAQIAGVDRIFACGGAQAVAALAFGTKSIPKVDKICGP 219

Query: 210 GNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVI 269
           GN FVT AK+ V   +D   ID   GPSEVL++AD  A  ++ ASD+L+QAEH   +  I
Sbjct: 220 GNIFVTLAKKAVFGVVD---IDGLQGPSEVLIVADQYANAEYCASDILAQAEHDALASSI 276

Query: 270 LLTPAADMARRVAEAVERQLAELPRAETARQALNASRLI-VTKDLAQCVEISNQYGPEHL 328
           L+T + D+A RV + VE +     R +  +Q+L  + LI V  ++ + ++++N Y  EHL
Sbjct: 277 LITTSEDLANRVNDIVESKADTCSRRDIIKQSLRDNGLIAVVDNINEAIKLANMYAAEHL 336

Query: 329 IIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQK 388
            +  +++ + +  I  AG +F G+ +    GDY +G +H LPT G     S L + DF K
Sbjct: 337 CLLVKDSEKYLTQINHAGCIFYGEKASVVMGDYVAGPSHALPTSGTARFSSPLNILDFVK 396

Query: 389 RMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRV 427
            + + ++ K+  + L     T+A AE L  H  AV  R+
Sbjct: 397 YIDIVKVDKQDIAKLGQAAATIAKAEGLECHAEAVLKRL 435


>UniRef50_C9KKX1 Histidinol dehydrogenase n=1 Tax=Mitsuokella multacida DSM 20544
           RepID=C9KKX1_9FIRM
          Length = 447

 Score =  274 bits (701), Expect = 4e-72,   Method: Compositional matrix adjust.
 Identities = 157/397 (39%), Positives = 236/397 (59%), Gaps = 9/397 (2%)

Query: 36  VNDILDNVKARGDEALREYSAKFDKTTVTA--LKVSAEEIAAASERLSDELKQAMAVAVK 93
           V  I+ +V+  GD A+  Y+   D+         V+  E  AA +     + +++  A +
Sbjct: 50  VRQIVGDVRREGDAAVIRYTHLIDRVDYKPEDFLVTEAEYEAAEKAADPAVVESLRKAAE 109

Query: 94  NIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAG 153
           N+  +H  QK        + G    Q   P+  VG+Y+PGG+A   S+V+M A PAS+AG
Sbjct: 110 NVRRYHQEQKPNSWMTYREKGSILGQSIIPLDRVGIYVPGGTAAYPSSVIMNAVPASVAG 169

Query: 154 CKKVVLCSPPP---IADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPG 210
             ++++  PP    I   +L AA+  GV+ ++ +GGAQAIAA+AFGTE++P+VDKI GPG
Sbjct: 170 VGEIIMMVPPKNGKINPYVLIAARAAGVKKIYKIGGAQAIAAMAFGTETIPRVDKITGPG 229

Query: 211 NAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVIL 270
           N FVT AK++V   +D   IDM AGPSE+L++AD  A P + A+D+LSQAEH P +  I+
Sbjct: 230 NIFVTLAKKEVYGHVD---IDMLAGPSEILIVADKTADPVYTAADMLSQAEHDPLASSIV 286

Query: 271 LTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVT-KDLAQCVEISNQYGPEHLI 329
           +T  A++A +VA+  E+QLA LPR E A+ +++ + LIV   D+ Q +  +N   PEH+ 
Sbjct: 287 ITDDAELAEKVAKEAEKQLAALPRREIAQASIDRNGLIVVADDMMQAMRFANVSAPEHME 346

Query: 330 IQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKR 389
           + T    +L+  +  AG+VFLG +SPE  GDY +G NHVLPT G     S L +  F KR
Sbjct: 347 LLTAQPFQLLPYVRHAGAVFLGAYSPEPLGDYFAGPNHVLPTGGTARYYSVLNVETFMKR 406

Query: 390 MTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
            ++   ++   S ++  I  LA  E L AH NA+ +R
Sbjct: 407 TSIISYTQPALSDVSEDIIRLAETEGLQAHANAIRIR 443


>UniRef50_UPI00017455E1 Histidinol dehydrogenase n=1 Tax=Verrucomicrobium spinosum DSM 4136
           RepID=UPI00017455E1
          Length = 428

 Score =  274 bits (700), Expect = 6e-72,   Method: Compositional matrix adjust.
 Identities = 160/406 (39%), Positives = 238/406 (58%), Gaps = 10/406 (2%)

Query: 28  ASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA--LKVSAEEIAAASERLSDELK 85
           AS+ +   V  ++ +++  GD+AL E + KFD  T+TA  L VS EE+AAA   L+ E++
Sbjct: 24  ASDRVRDVVAAVIADIRQNGDKALLELTQKFDGATLTAEQLVVSTEEVAAAVASLTPEVR 83

Query: 86  QAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLML 145
            A+  +++N+ TF          +  + G    +V  P   VG+Y+PGG+APL ST +M 
Sbjct: 84  AALDASLRNVTTFAHQSLRKDWSMINEQGAEVGEVYHPFERVGVYVPGGTAPLVSTAIMT 143

Query: 146 ATPASIAGCKKVVLCSP----PPIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVP 201
              A+ AG  ++V+CSP      +   +L A  L G  +++ VGG+QAIAA+AFGTE++ 
Sbjct: 144 VAIAAAAGVPEIVVCSPCGKDGKVNANLLAALSLAGATEIYRVGGSQAIAAMAFGTETIK 203

Query: 202 KVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAE 261
            V KIFGPGN++V EAKRQV       ++D+  GPSEV+V+ADS A P F+A+DLL+QAE
Sbjct: 204 PVTKIFGPGNSYVVEAKRQV---FGVVSVDLLPGPSEVMVLADSSANPAFIAADLLAQAE 260

Query: 262 HGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNAS-RLIVTKDLAQCVEIS 320
           HG DS V  LT    +   V   VE Q  +L R E  R  L+    L++   L +  EI 
Sbjct: 261 HGKDSGVAFLTDDETLLNAVVSQVETQGQKLTRQEMVRSVLDKECFLMLVPTLEEGAEIV 320

Query: 321 NQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSS 380
           N Y PEHL + T    +++  I +AG++FLG++SP + GD+ +G +H LPT G   +   
Sbjct: 321 NNYAPEHLSLITAREHDILPLIRTAGAIFLGNYSPVAVGDFLAGPSHTLPTGGAGKSFPG 380

Query: 381 LGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
           L +  FQKR ++  LSKE  +     +   +  E L AH  +V++R
Sbjct: 381 LTVDMFQKRTSIVRLSKEACAKSEPIVRVFSEIEGLDAHGLSVSVR 426


>UniRef50_C1PFR7 Histidinol dehydrogenase n=1 Tax=Bacillus coagulans 36D1
           RepID=C1PFR7_BACCO
          Length = 427

 Score =  273 bits (698), Expect = 1e-71,   Method: Compositional matrix adjust.
 Identities = 151/405 (37%), Positives = 229/405 (56%), Gaps = 8/405 (1%)

Query: 30  ESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAMA 89
           E + RT  ++L++++  GD A+++Y+AKFD     + +V  EE   A   +  ++  A+ 
Sbjct: 26  EGVLRTAKEVLEDIRLNGDAAVKKYTAKFDGEVPESWEVLPEERKQAWHEVPQDVISALQ 85

Query: 90  VAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPA 149
            A +NI  FH  Q      +E    +   Q+ RPV   G+Y+PGG+A   S+VLM A PA
Sbjct: 86  KAAENIRRFHAKQLQNSRIMEMNENIISGQLFRPVEKAGIYVPGGTACYPSSVLMNAIPA 145

Query: 150 SIAGCKKVVLCSPP----PIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDK 205
            +AG ++V++ +P      IA  +  AA + GV  ++ +GG QAI ALA+GTE++PKVDK
Sbjct: 146 VLAGVEEVIMATPARNGTKIAPVLSVAADIAGVGTIYKLGGIQAIGALAYGTETIPKVDK 205

Query: 206 IFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPD 265
           I GPGNA+V  AK  V   +    IDM AGPSEV +IAD  A P ++A+DL++QAEH   
Sbjct: 206 IVGPGNAYVAAAKSLVYGTV---GIDMIAGPSEVAIIADENANPVYIAADLIAQAEHDER 262

Query: 266 SQVILLTPAADMARRVAEAVERQLAELPRAETARQALNA-SRLIVTKDLAQCVEISNQYG 324
           ++  L T +  +      A+E+QL  LPR +    ++   S  ++ + + +   +SN+  
Sbjct: 263 ARTFLFTTSQKLINETKSALEKQLVVLPRRDIGEVSIKMQSAAVLVESIDEAFALSNRLA 322

Query: 325 PEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLA 384
           PEHL IQ  N    +  + +AGSVFLG+ +PE+ GDY  G NH+LPT G     S L + 
Sbjct: 323 PEHLEIQVENPLLQLSKVKNAGSVFLGENTPEAIGDYYGGPNHILPTSGTARFSSGLSVD 382

Query: 385 DFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNA 429
           DF K++T     ++     A  +  +A  E+L  H  AV  RV  
Sbjct: 383 DFYKKITYLYYGEKALQQAAPDVMAIATEEQLAGHARAVQKRVKG 427


>UniRef50_Q313T7 Histidinol dehydrogenase n=7 Tax=Deltaproteobacteria
           RepID=HISX_DESDG
          Length = 434

 Score =  272 bits (696), Expect = 2e-71,   Method: Compositional matrix adjust.
 Identities = 163/408 (39%), Positives = 241/408 (59%), Gaps = 13/408 (3%)

Query: 31  SITRTVNDILDNVKARGDEALREYSAKFDKTTV--TALKVSAEEIAAASERLSDELKQAM 88
           S+   V +I+D +++ GD AL  Y+ +FD      ++L+V+ + I  A+  +     Q +
Sbjct: 30  SVEPVVREIMDAIRSDGDAALAGYTRRFDCPDFDPSSLRVAPDAIEKAAREIPRHDLQII 89

Query: 89  AVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGG---SAPLFSTVLML 145
             A  NI  FH+AQK     +    G    Q+TRPV S GLY+PGG   + PL S++LM 
Sbjct: 90  TEAADNIRHFHSAQKEEAWFITRPDGTVLGQMTRPVDSAGLYVPGGQGGNTPLISSLLMN 149

Query: 146 ATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVP 201
           A PA +AG  ++ + +PP     +   IL AA + G+ +++  G A A+AALA+GT+++ 
Sbjct: 150 AVPAQVAGVPRIAVTTPPRKDGTLNPYILAAAHVLGLDEIYCAGSAWAVAALAYGTQTIA 209

Query: 202 KVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAE 261
            VD I GPGN FVT AKR +   +    IDM AGPSE+L+IADS A    VA+D+LSQAE
Sbjct: 210 PVDFIAGPGNIFVTTAKRML---IGTVGIDMIAGPSEILIIADSQADAAHVAADMLSQAE 266

Query: 262 HGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVEIS 320
           H P +  IL+TP+  +A  V   +E+Q+  L RA+ AR +L + S ++VT DL   VE+S
Sbjct: 267 HDPLASAILVTPSPQLAAAVHTELEKQVTGLDRADIARASLRDWSAIVVTPDLNSAVELS 326

Query: 321 NQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSS 380
           N+  PEHL +  ++   L+ SI +AG++F+G  SPE  GDY +G NHVLPT G     S+
Sbjct: 327 NKVAPEHLELLVQDTWGLLGSIRNAGAIFMGPHSPEPVGDYFAGPNHVLPTMGTARFSSA 386

Query: 381 LGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVN 428
           L +  F K+ ++   S+      A+ I  LA  E L AH  +V  R++
Sbjct: 387 LSVQSFCKKSSIIAASQTFTQTNAAKIARLARLEGLEAHARSVESRLS 434


>UniRef50_B3T638 Histidinol dehydrogenase n=1 Tax=uncultured marine crenarchaeote
           HF4000_ANIW141N1 RepID=B3T638_9ARCH
          Length = 434

 Score =  271 bits (692), Expect = 5e-71,   Method: Compositional matrix adjust.
 Identities = 158/417 (37%), Positives = 242/417 (58%), Gaps = 21/417 (5%)

Query: 29  SESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAM 88
           SE   +TV  IL++V+  GD A+++Y  KF+    + L+VS +EI  A E          
Sbjct: 22  SEKDRKTVQAILNDVRKNGDSAVKKYERKFNGRKTSQLRVSNKEIGEAEELPDPTDNIWT 81

Query: 89  AVAVKNIETFHT----AQKL--------PPVDVETQPGVRCQQVTRPVASVGLYIPGGSA 136
            + ++  + +       QKL         P      P ++ ++   P+ SVG YIPGG A
Sbjct: 82  KLYLQEWDLYWNLSGRKQKLRKGGFCYEKPYFWGGLP-LKTEKRFVPIPSVGCYIPGGQA 140

Query: 137 PLFSTVLMLATPASIAGCKKVVLCSPPPIADEI----LYAAQLCGVQDVFNVGGAQAIAA 192
              S+V+M   PA IAG K++V+ SPP    +I    + AA +CGV +++ VGGAQAI A
Sbjct: 141 RYPSSVVMSVLPAKIAGVKRIVIVSPPGRDGKIDPLTISAAAMCGVTEIYKVGGAQAIGA 200

Query: 193 LAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFV 252
           LA+GT+S+PKVDKI GPG  FV+ AK  VS++    +IDM AGP+E+ ++AD+ + P+ V
Sbjct: 201 LAYGTKSIPKVDKIVGPGGKFVSIAKAIVSEQ---TSIDMIAGPTELGIMADTSSDPELV 257

Query: 253 ASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLI-VTK 311
           A DL+SQAEH  D+   ++T +  +A+++ +++E+ +    R+   R++L  +  I V K
Sbjct: 258 ALDLISQAEHSKDTMCFVITQSKIIAKQIQKSIEKLIPGTERSSIIRESLTKNGFIAVCK 317

Query: 312 DLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPT 371
           +  + +E++N+  PEHL +  +NAR L   IT AG + +G  +P SA DY  GTNH+LPT
Sbjct: 318 NENEMIELANKIAPEHLELMVKNARSLSKKITGAGLLLIGKNTPSSASDYILGTNHILPT 377

Query: 372 YGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVN 428
            G+  T   L + DF K  T+ E  K    AL+S ++ L  AE L  H  AV  R++
Sbjct: 378 NGFGRTRGGLSVLDFLKLQTIVESKKSTLKALSSDLKALTDAEGLPNHYKAVKRRLD 434


>UniRef50_A5D1M4 Histidinol dehydrogenase n=1 Tax=Pelotomaculum thermopropionicum SI
           RepID=A5D1M4_PELTS
          Length = 437

 Score =  270 bits (689), Expect = 1e-70,   Method: Compositional matrix adjust.
 Identities = 157/429 (36%), Positives = 241/429 (56%), Gaps = 24/429 (5%)

Query: 13  TAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA--LKVSA 70
           +AE   +++ R  +  ++S+   V  ++ +VK+RGD+AL +Y+ +FD  T++A  ++VS 
Sbjct: 12  SAEDYNRIMKRSEVE-TDSVIGEVKKVIADVKSRGDDALVDYTREFDGITISAEKIRVSP 70

Query: 71  EEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPP--VDVETQPGVRCQQVTRPVASVG 128
           EEI  A  ++  E  +A+     N+  FH AQ +P     +E  PG+   QV  P+  VG
Sbjct: 71  EEIKEAYHKVDRETVEAIKTLAGNVRRFHAAQ-MPNKMWSMEVSPGLVAGQVIIPLDRVG 129

Query: 129 LYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSP-------PPIADEILYAAQLCGVQDV 181
            Y+PGG     S V+M   PA +AG  +V++C+P       PP     L A  +CG   V
Sbjct: 130 CYVPGGRGWFPSAVMMSVLPARVAGVPEVIVCTPSAPDGSVPP---GTLVACDICGADAV 186

Query: 182 FNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLV 241
           F +GG+QA+AA+A+GT++VPKVDKI GPG+ +V  A + +   ++   I   AGP E L+
Sbjct: 187 FRIGGSQAVAAMAYGTQTVPKVDKIVGPGSKWVLAAFKLLYGEVE---IGTHAGPGEGLI 243

Query: 242 IADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMA----RRVAEAVERQLAELPRAET 297
           IAD  A P+F A+D+  QAEHG DS  +L+T   ++A    +++A  +ER L E  +   
Sbjct: 244 IADETADPEFAAADICIQAEHGLDSAGVLVTHVEELAWAVQKKIARHIER-LNEYRKNFV 302

Query: 298 ARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPES 357
                    +I+T  L + +  +N Y  EHL I TR+   ++  I +AG ++LG ++P S
Sbjct: 303 VESLKKYGAIIITSSLEESIAFANDYAVEHLEIMTRDPLHVMQKIKNAGGIYLGHYTPLS 362

Query: 358 AGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLT 417
            G + SG NHVLPT         L  ADF K +T + LS+EG ++L   +  LA  E   
Sbjct: 363 CGCFGSGPNHVLPTGRKAKVSGGLKTADFYKAVTFEYLSREGLASLKDAMVKLAEYEGFP 422

Query: 418 AHKNAVTLR 426
           AH NA+  R
Sbjct: 423 AHGNAILER 431


>UniRef50_C1FAE2 Histidinol dehydrogenase n=1 Tax=Acidobacterium capsulatum ATCC
           51196 RepID=C1FAE2_ACIC5
          Length = 428

 Score =  269 bits (688), Expect = 1e-70,   Method: Compositional matrix adjust.
 Identities = 168/400 (42%), Positives = 240/400 (60%), Gaps = 23/400 (5%)

Query: 39  ILDNVKARGDEALREYSAKFDKTTVTA-LKVSAEEIAAASERLSDELKQAMAVAVKNIET 97
           I+  V+  GD AL  Y AKFD    +  L++ AEE+ AA +  + ELK A+  A KNI  
Sbjct: 39  IVQGVRRGGDAALLRYRAKFDGIAASEPLRIPAEEMEAAWKATTAELKAALKQAAKNIRR 98

Query: 98  FHTAQKLPPVDVETQ--PGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCK 155
           F  AQK  P D   Q  PGV   Q   P+ +VG Y+P G  PL ST+LM A PA +AG +
Sbjct: 99  F--AQKQRPRDFTLQMAPGVTAGQKVIPLEAVGCYVPSGRYPLPSTLLMTAIPAQVAGVR 156

Query: 156 KVVLCSPPPIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVT 215
           ++V  SP P A E L AA + GV + + +GGAQA+AALA+GT S+ +V KI GPGNA+VT
Sbjct: 157 RIVAVSPRP-AKETLAAAHMLGVAEFYRIGGAQAVAALAYGTASIERVGKIVGPGNAYVT 215

Query: 216 EAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAA 275
            AK+ VS   D   IDM AGP+E+++ +++G T + +A+DL++QAEH PD+  IL+T  A
Sbjct: 216 AAKKAVS--FD-CGIDMLAGPTEIVIASENG-TVEGIAADLVAQAEHDPDAIAILVTSNA 271

Query: 276 DMARRVAEAVERQLAELPRAET---ARQALNAS-RLIVTKDLAQCVEISNQYGPEHLIIQ 331
            + R VA   +       RA++   A+Q++ A+  +I+T+D+ +   ++NQ   EHL + 
Sbjct: 272 ALGRAVAAKTKL------RAQSNAIAKQSIAANGAVILTRDVEEARMLTNQLAAEHLTV- 324

Query: 332 TRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMT 391
             ++   +  + +AGSVF+G WS +  GDY SG NH LPT G       L + D+ K +T
Sbjct: 325 --DSSADLAWVRNAGSVFVGRWSSQPLGDYVSGPNHTLPTSGLARLRGGLSVMDYLKLVT 382

Query: 392 VQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNALK 431
           VQE S  G   L  +   LA AE L  H +AV +R+ + K
Sbjct: 383 VQEYSATGVRQLGPSAVALAEAEGLVGHADAVRVRLQSAK 422


>UniRef50_A6UA68 Histidinol dehydrogenase n=4 Tax=Proteobacteria RepID=A6UA68_SINMW
          Length = 432

 Score =  269 bits (687), Expect = 2e-70,   Method: Compositional matrix adjust.
 Identities = 155/409 (37%), Positives = 224/409 (54%), Gaps = 6/409 (1%)

Query: 23  RPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSD 82
           R A+S +  + +TV +I+ NV+ RGD A+REYSA FDK  +   +VS EE   A   L  
Sbjct: 20  RDAVSDTAPVEKTVKEIIANVRERGDAAVREYSAAFDKVELEKFEVSQEERLKAVAELDP 79

Query: 83  ELKQAMAVAVKNIETFHTAQ--KLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFS 140
           + ++    A+ N+  F  AQ   + P+++ET PG+       P+  VG Y+PGG  PL S
Sbjct: 80  QTREDTEFAIANVRAFAEAQLKTILPLEIETLPGLHLGHRVIPIEIVGCYVPGGRYPLLS 139

Query: 141 TVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESV 200
             +M   PA +AGC +V+ C PP     ++    L G   +F VGGAQAIAA+A GTE++
Sbjct: 140 APVMTIVPAKVAGCDQVIACLPPNAHPAMIAGCHLSGADRIFRVGGAQAIAAMASGTETI 199

Query: 201 PKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQA 260
           P VDKI GPGNAFV EAKRQV  ++    ID  AGPSE+ ++AD       +A+DLL+QA
Sbjct: 200 PAVDKIVGPGNAFVNEAKRQVFGQV---GIDQLAGPSEIFIVADETGKAAMIATDLLAQA 256

Query: 261 EHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVEI 319
           EH   ++V L+T    +A      VE+QL +L  A  A  A  +   + V +D    +  
Sbjct: 257 EHDVRTRVGLITTDRKLAEETLVEVEKQLQDLSTANVASVAWKDYGEITVCEDETTMIAY 316

Query: 320 SNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCS 379
           S+    EHL + TR+ +     + + GS+F+G+ +     D   GTNH LPT        
Sbjct: 317 SDYIAAEHLQVHTRDPQATARKLRNYGSLFIGELASVVYSDKCCGTNHTLPTMAAGRYTG 376

Query: 380 SLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVN 428
            L +  + K  T Q L + G +A+A      +A ERL  H+ A  LR++
Sbjct: 377 GLWVGSYLKTCTHQWLDERGVAAVAPAAVRQSATERLEGHRRAAALRLS 425


>UniRef50_B2UMH6 Histidinol dehydrogenase n=3 Tax=Verrucomicrobia RepID=B2UMH6_AKKM8
          Length = 432

 Score =  267 bits (682), Expect = 7e-70,   Method: Compositional matrix adjust.
 Identities = 159/424 (37%), Positives = 243/424 (57%), Gaps = 12/424 (2%)

Query: 10  NSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV--TALK 67
           ++C  E +R++  R      +S+  TVN I+ +V  RGDEAL +Y+A+FDK  +  ++L 
Sbjct: 8   DTCFDEMKRRMNRRAL--PEDSVRDTVNAIIRDVSVRGDEALFDYAARFDKAHLDSSSLF 65

Query: 68  VSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASV 127
           V+  E+A A   + + +K+A+AV++ NI  F    +          GV   +   P   V
Sbjct: 66  VTEAELAEAEAMVEESVKEAIAVSLANIHYFSDRSRRRDWSGVNAQGVEVAERFLPYDRV 125

Query: 128 GLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSP----PPIADEILYAAQLCGVQDVFN 183
           G+YIPGG APL ST +M    A  AG +++V  +P      +   +LYA +  G  ++  
Sbjct: 126 GIYIPGGKAPLVSTSIMTGGFAQAAGVREIVAATPCGPDGRVNPALLYALKASGATEIVK 185

Query: 184 VGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIA 243
           +GGAQAIAALA GTESV  V+KIFGPGN FV EAKRQ+   +   AID+  GPSEV+V+A
Sbjct: 186 IGGAQAIAALALGTESVRPVEKIFGPGNRFVVEAKRQL---VGAVAIDLLPGPSEVMVLA 242

Query: 244 DSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALN 303
           D  A  +F+A+DLL+Q EHGPDS V+ +T +  +  +V   VERQ A L R    R+ L+
Sbjct: 243 DDTADAEFLAADLLAQGEHGPDSVVVFVTTSKALLEQVEAEVERQAALLSRGSIIREVLD 302

Query: 304 ASRL-IVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYA 362
                 +   + + VE+ N + PEHL++ TR+   +++ I +AG+++ G  S  + GD+ 
Sbjct: 303 KHAYGFLVSSIQEGVELVNAFAPEHLVLVTRDEEAVLNGIRTAGAIYAGSLSTVACGDFL 362

Query: 363 SGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNA 422
           +G +H LPT G   + S L    FQ+R +V  + +      A  +   A  E L AH ++
Sbjct: 363 AGPSHTLPTGGAGKSFSGLRADQFQRRTSVVRMDRNAVLNSAPYVAEFARVEGLDAHNHS 422

Query: 423 VTLR 426
           + +R
Sbjct: 423 IQVR 426


>UniRef50_B6A0U7 Histidinol dehydrogenase n=1 Tax=Rhizobium leguminosarum bv.
           trifolii WSM2304 RepID=B6A0U7_RHILW
          Length = 448

 Score =  267 bits (682), Expect = 7e-70,   Method: Compositional matrix adjust.
 Identities = 167/446 (37%), Positives = 244/446 (54%), Gaps = 19/446 (4%)

Query: 4   NTIIDWNSCTA--EQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKT 61
           +T++  ++ +A  + QR+ L++   S   +    VN I++ V+  GD AL +++ +FDK 
Sbjct: 3   DTLVSIHTLSALDDAQRKALLQRTESDLSAFIDKVNPIIEAVRIDGDAALADFARQFDKA 62

Query: 62  TVTA--LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDV--ETQPGVRC 117
            V A  L+ + EE +AA   +  EL   +  A  NI  FH  Q +P   V  ET  GV  
Sbjct: 63  QVAADQLRATTEEFSAARASIDPELITTLEFAAGNIRHFHEKQ-MPETLVLHETHRGVLV 121

Query: 118 QQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAA 173
                 + SV  Y+P G     S+VLM A PA +AG +KVV+ +PP     +    L AA
Sbjct: 122 GDRWNAIDSVACYVPRGKGSFPSSVLMTAIPAKVAGVRKVVIITPPGPDGTVDPATLVAA 181

Query: 174 QLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMP 233
           ++ GV DVF  GGAQAIAA+AFGT++VPK DK+ GPG+ +V  AK+Q+S  +D  +   P
Sbjct: 182 EIAGVSDVFKCGGAQAIAAVAFGTQTVPKCDKVVGPGSPWVVAAKKQLSSLIDPGS---P 238

Query: 234 AGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELP 293
           AGPSE+++ +D     + VA DL  ++EHGPDS V  +T  AD A  VA  V    + + 
Sbjct: 239 AGPSELIIFSDGSVPAELVALDLCVESEHGPDSSVFFVTDNADFANAVASCVPALWSRMG 298

Query: 294 --RAETARQALNASR--LIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVF 349
             RA+ ++  L+  R  +++ +  A  +   N Y PEHL +   NA + +     AG + 
Sbjct: 299 NIRAQYSKTVLSGPRGGIVIARTRADALAFVNDYAPEHLAVLADNAWQYLACFEHAGEIL 358

Query: 350 LGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIET 409
           LG  S  S  ++  G +HVLPT G   T S L + DF KR ++  LSKE +   A+  E 
Sbjct: 359 LGPHSAISVANFVLGPSHVLPTGGAAKTTSPLSVFDFLKRTSIASLSKEAYGGFAAHAER 418

Query: 410 LAAAERLTAHKNAV-TLRVNALKEQA 434
           LA  E    H NAV T+R  AL+  A
Sbjct: 419 LARYEGFDGHANAVSTIRDEALRSAA 444


>UniRef50_Q1D4L9 Histidinol dehydrogenase n=2 Tax=Cystobacterineae
           RepID=Q1D4L9_MYXXD
          Length = 437

 Score =  266 bits (681), Expect = 9e-70,   Method: Compositional matrix adjust.
 Identities = 174/413 (42%), Positives = 243/413 (58%), Gaps = 9/413 (2%)

Query: 15  EQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIA 74
           E  R+LL R A  +   +   V +I+  V+A GD+AL E + +FD+  +TAL+V  E  A
Sbjct: 22  EDVRRLLDR-ATGSDARVALRVREIIARVRAEGDQALFELARQFDRVELTALEVPREVCA 80

Query: 75  AASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGG 134
           AA   L   ++ A+A A +NI   H  QK   V+VET+PGV   +   P+  VG+Y PGG
Sbjct: 81  AALAGLEPSVRDALARAARNIALAHAPQKPQWVEVETEPGVLVGRRPDPLGRVGVYAPGG 140

Query: 135 SAPLFSTVLMLATPASIAGCKKVVLCSPP-PIA---DEILYAAQLCGVQDVFNVGGAQAI 190
            A   S+VLM   PA +AG  +V++CSPP P       +L AA L G   VF++GGA A+
Sbjct: 141 RAVYPSSVLMGVVPAKVAGVGEVIVCSPPGPDGLPHPSVLAAASLAGADRVFSLGGAGAV 200

Query: 191 AALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPD 250
           AA+A GTESVP+VD+I GPGNA+V EAK QV   +   AI+ PAGPSE+LV+AD  A P 
Sbjct: 201 AAMAHGTESVPRVDRIVGPGNAYVAEAKLQV---VGAVAIEAPAGPSEILVVADDTANPA 257

Query: 251 FVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVT 310
            VA ++L+QAEH P++  + L     +A  +A  VERQ     R E    AL +   ++T
Sbjct: 258 AVAREMLAQAEHDPEAACVTLALGDALADAIAAEVERQAERAKRWEIVTSALGSRGAVLT 317

Query: 311 -KDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVL 369
              L +       + PEHL+I T + RE +  + +AG+VFLG+ S  + GDY +G+NHVL
Sbjct: 318 VASLEEAWPFVADFAPEHLLIATASPREDLGQVRNAGTVFLGERSSVAYGDYMTGSNHVL 377

Query: 370 PTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNA 422
           PT G     S L L DF +  T Q ++    ++LA  +  LA +E L AH +A
Sbjct: 378 PTAGLARAYSGLNLLDFYRWTTYQRVAPTAAASLAEDVGRLADSEGLFAHADA 430


>UniRef50_Q4A044 Histidinol dehydrogenase n=62 Tax=Staphylococcus RepID=HISX_STAS1
          Length = 423

 Score =  265 bits (678), Expect = 2e-69,   Method: Compositional matrix adjust.
 Identities = 143/404 (35%), Positives = 234/404 (57%), Gaps = 11/404 (2%)

Query: 27  SASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQ 86
           S +E +   V DI +NV+  GD+ALR Y+ +FD+     L+V+ + +  A  RL  +L++
Sbjct: 17  SLNEDLYPIVKDICENVRLHGDDALRNYNQQFDQVETCNLEVAYQTLENAYNRLDSDLRE 76

Query: 87  AMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLA 146
           A+  +   I+++  + K      + Q    C ++  P+  VG+Y+PGG A   STVLM  
Sbjct: 77  ALQQSHARIQSYQESIKW----TKQQGTSDCYELYHPLERVGVYVPGGKASYPSTVLMTV 132

Query: 147 TPASIAGCKKVVLCSPPP---IADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKV 203
           T A +AG K + + +PP    I D +L A  + GV +V+ VGGAQ+IAALA+GTE++PKV
Sbjct: 133 TLAKVAGVKNISVVTPPQLNGIPDIVLAACYIAGVDNVYQVGGAQSIAALAYGTETLPKV 192

Query: 204 DKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHG 263
           DKI GPGN FV  AK+ +  ++    ID  AGPSE+ +I D  A  D +A D+ +QAEH 
Sbjct: 193 DKIVGPGNQFVAYAKKYLFGQV---GIDQIAGPSEIALIIDDSADLDAIAYDVFAQAEHD 249

Query: 264 PDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASR-LIVTKDLAQCVEISNQ 322
             ++  +++    + +++ + ++  L ++ R    + +LN +  LI   + ++  ++ NQ
Sbjct: 250 ELARTFVISEDEALLKQLEQKIQHILPQIERQSIVQASLNDNHFLIHVNNFSEACDLMNQ 309

Query: 323 YGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLG 382
             PEH  IQT +  + ++ +   G++FLG +SPE  GDY +G +HVLPT       + L 
Sbjct: 310 IAPEHASIQTVSPHDYLNHVRYVGALFLGYYSPEVIGDYVAGPSHVLPTNQTARFTNGLS 369

Query: 383 LADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
           + DF  R +V +LSK+ F  +  T   LA  E+L  H+ ++ +R
Sbjct: 370 VNDFLTRHSVIDLSKDTFDTVELTARKLAHVEQLYNHEQSIEIR 413


>UniRef50_Q3IQR5 Histidinol dehydrogenase n=10 Tax=Halobacteriaceae RepID=HISX_NATPD
          Length = 422

 Score =  265 bits (678), Expect = 2e-69,   Method: Compositional matrix adjust.
 Identities = 170/405 (41%), Positives = 238/405 (58%), Gaps = 13/405 (3%)

Query: 30  ESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAMA 89
           E    +V DI+  V+  GD ALR Y+ +FD   +  L V+ +E   A + L D+L+ A+ 
Sbjct: 25  EDARESVRDIIGRVREEGDVALRSYAKEFDDVDIGTLAVT-DEAERAYDDLDDDLRDAIE 83

Query: 90  VAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPA 149
            A +NI TFH  Q +P    E   G    +  RP+  VG+Y PGG+A   S+VLM   PA
Sbjct: 84  TAAENIRTFHERQ-VPDDWREQFDGRELGRRYRPLERVGVYAPGGTAAYPSSVLMGVIPA 142

Query: 150 SIAGCKKVVLCSPPPIADEI----LYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDK 205
            +AG   V + +PP  A+E+    L AA + G   V+ VGGAQAIAALA+GTESV  V K
Sbjct: 143 VVAGVDHVAVATPP--AEELPAATLAAAHVAGADAVYQVGGAQAIAALAYGTESVSAVQK 200

Query: 206 IFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPD 265
           + GPGN +VT AK +V   ++   ID  AGPSE+LV+ D  A P+ +A+D+++QAEH P+
Sbjct: 201 VVGPGNRWVTAAKAEVRGDVE---IDFLAGPSELLVVCDDTADPELIAADMVAQAEHDPN 257

Query: 266 SQVILLTPAADMARRVAEAVERQLAELPRAETARQAL--NASRLIVTKDLAQCVEISNQY 323
           + V+ ++     A  VA+A ERQ     R E    AL  +AS ++  + +++ V  + +Y
Sbjct: 258 ASVVCVSDDEATAEAVADACERQATARERTEAIESALENDASAVLCARSMSEAVLFAEEY 317

Query: 324 GPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGL 383
             EHL I   +   L+D I SAGSVFLG +SP + GDYASGTNHVLPT G       L +
Sbjct: 318 AAEHLSIVAADEEALLDRIDSAGSVFLGGFSPVAVGDYASGTNHVLPTGGLAKVAGGLSV 377

Query: 384 ADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVN 428
             F +  TVQ+L ++  S+L  T+ TLA AE L AH  +V  R +
Sbjct: 378 DHFVRSTTVQKLDEDALSSLRETVTTLARAEGLEAHAESVDKRFD 422


>UniRef50_A3EUM9 Histidinol dehydrogenase n=3 Tax=Leptospirillum RepID=A3EUM9_9BACT
          Length = 445

 Score =  264 bits (675), Expect = 4e-69,   Method: Compositional matrix adjust.
 Identities = 158/423 (37%), Positives = 245/423 (57%), Gaps = 13/423 (3%)

Query: 20  LLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFD--KTTVTALKVSAEEIAAAS 77
           +  R   S  E++   V+ IL +++  GD AL  Y+ + D  +  +  L+VS   +  + 
Sbjct: 24  IFQRGRDSEGETLRARVSSILGDIRREGDVALLRYARELDGFRGELKDLRVSPGRMEESF 83

Query: 78  ERLSDELKQAMAVAVKNIETFHTAQKLPPVD-VETQPGVRCQQVTRPVASVGLYIPGGSA 136
             L  E+++A+  A   IE FH A +   +  + ++PG +   + RP+  VG+Y+PGG+A
Sbjct: 84  GALPSEIRKALVFAKDRIEEFHGALREKGLSGLASRPG-KGGVLVRPLHRVGVYVPGGTA 142

Query: 137 PLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCGVQDVFNVGGAQAIAAL 193
              STVLM A  A +AG K++V  SP     I D IL A  +CGVQDV+ VGG  AIAA+
Sbjct: 143 AYPSTVLMTAVVAKVAGVKQIVGVSPAGPGGIPDAILAAFHVCGVQDVYQVGGVHAIAAM 202

Query: 194 AFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVA 253
           A+GT ++P+VDKI GPGN +V EAKRQV   +D   IDM AGP+E+L++AD  A P+++A
Sbjct: 203 AYGTGTIPRVDKIVGPGNRYVAEAKRQVFGDVD---IDMVAGPTEILILADDSARPEWLA 259

Query: 254 SDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQA-LNASRLIVTKD 312
           +D+++QAEH   +  +L+     +A+ V  A+ERQ++ LPR + A ++ L    ++V   
Sbjct: 260 ADMIAQAEHDTRASAVLILTDMTLAKAVVLALERQISSLPRQKIAEESLLKYGFILVVPS 319

Query: 313 LAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTY 372
           +   VEIS+   PEHL +Q RN  + +  I +AG+VFLG    E+ GDY  G +HVLPT 
Sbjct: 320 VQVAVEISDLVAPEHLELQVRNPEKWLGLIQNAGAVFLGSEMAEAFGDYCFGPSHVLPTN 379

Query: 373 GYTATCSSLGLADFQKRMTVQE--LSKEGFSALASTIETLAAAERLTAHKNAVTLRVNAL 430
           G     S + +  F KR ++ E   S++    +      LA  E L  H  +   R+  +
Sbjct: 380 GSARFSSPVSIETFTKRTSLLEGFRSRQELEDVVRNSALLARLEGLEGHARSALARLENV 439

Query: 431 KEQ 433
           +++
Sbjct: 440 QKE 442


>UniRef50_B1H0F0 Histidinol dehydrogenase n=1 Tax=uncultured Termite group 1
           bacterium phylotype Rs-D17 RepID=B1H0F0_UNCTG
          Length = 419

 Score =  264 bits (674), Expect = 6e-69,   Method: Compositional matrix adjust.
 Identities = 144/403 (35%), Positives = 234/403 (58%), Gaps = 22/403 (5%)

Query: 29  SESITRTVNDILDNVKARGDEALREYSAKFDKTTVT--ALKVSAEEIAAASERLSDELKQ 86
           ++ I+  V+DI++++K  GDEA+ +Y  KFD   ++    +VS + I  A++R+  +LK 
Sbjct: 17  AKQISIYVSDIIEDIKNNGDEAVFKYLKKFDNVDLSKKGYRVSQKVIDDAAKRIPKQLKN 76

Query: 87  AMAVAVKNIETFHTAQK--LPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLM 144
            +  +  NI  +H  ++  +       + G++  Q  RPV SVGLY+PGG  P  STV+M
Sbjct: 77  VIKSSYSNILAYHKYERSQIKKRWNYVKNGLKIGQFYRPVESVGLYVPGGRFPYPSTVIM 136

Query: 145 LATPASIAGCKKVVLCSPPP-IADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKV 203
            A PA  AG K++V+ +PP  + D +L++A+LCG+++++ +GG  A+ ALA+GT+++ KV
Sbjct: 137 TAVPAMAAGVKRIVMVTPPKNMNDAVLFSAKLCGIKEIYCIGGVMAVGALAYGTKTLKKV 196

Query: 204 DKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHG 263
           D I GPGNA+V EAK+QV  R+    ID  AGP+EV +IAD     D+V +D+++Q EH 
Sbjct: 197 DMIVGPGNAYVNEAKKQVFGRV---GIDSLAGPTEVAIIADKDVPTDYVVADVMAQVEHD 253

Query: 264 PDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQCVEISNQY 323
           P ++  LL  +A     + + + ++  +  R E                L + V+I N  
Sbjct: 254 PLAKTYLLCESAKKMSEIEKLLPKEALKQLRTELC-------------SLNKAVDIVNNI 300

Query: 324 GPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGL 383
            PEHL +  +N + L+ ++ +AG+VF+G  +P ++GDY +G +HVLPT G     S L +
Sbjct: 301 APEHLELLVKNYQILLKNVRNAGAVFVGYQTPTASGDYWAGPSHVLPTNGSAKFSSGLSV 360

Query: 384 ADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
             F KR    E++K    A   TI   A AE +  HK +  +R
Sbjct: 361 MTFLKRSAYIEMNKNNKKAY-KTIADFAQAENMQYHKKSAEVR 402


>UniRef50_UPI00016BFCCC histidinol dehydrogenase n=1 Tax=Epulopiscium sp. 'N.t. morphotype
           B' RepID=UPI00016BFCCC
          Length = 419

 Score =  264 bits (674), Expect = 6e-69,   Method: Compositional matrix adjust.
 Identities = 174/411 (42%), Positives = 244/411 (59%), Gaps = 9/411 (2%)

Query: 21  LMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERL 80
           +++ +   S  I R   +I++ VK  GD+AL +Y+ KFD+  +T+L VS +E+  A E +
Sbjct: 11  ILKHSAEISPQIERDAQEIVETVKRLGDQALFDYALKFDRAQLTSLLVSEQELKDAYEXI 70

Query: 81  SDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFS 140
            D+L   +  A KNIE FH  Q      VE    +  Q+VT P+  VG+YIPGG A   S
Sbjct: 71  DDDLLGVIRRAKKNIEDFHKRQITNSFMVEKDGIIMGQRVT-PIERVGIYIPGGXAVYPS 129

Query: 141 TVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQDVFNVGGAQAIAALAFG 196
           +VLM   PA +AGC  + + +PP     +A EIL    + GV  VF +GGA AIAALA+G
Sbjct: 130 SVLMNVIPAKLAGCSYISVVTPPREDGTVAKEILAICAMLGVDQVFKIGGAGAIAALAYG 189

Query: 197 TESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDL 256
           TESV  V KI GPGNA+V  AK+ V  ++    IDM AGPSE+L+IAD    P  +A+D+
Sbjct: 190 TESVLPVYKITGPGNAYVAAAKKAVFGKV---GIDMIAGPSEILIIADEKQXPKIIAADM 246

Query: 257 LSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKD-LAQ 315
           LSQAEH   ++ ILLT + ++A  VA  +E QL++LP+ + AR +++ + LIV  D L++
Sbjct: 247 LSQAEHDMLARAILLTTSKEIAEEVATEIEIQLSKLPKEKIARPSIDDNGLIVVCDTLSE 306

Query: 316 CVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYT 375
           C  ISN   PEHL I   NA   +  I +AGSVFLG ++PE+ GDY +G NH LPT   +
Sbjct: 307 CFAISNDLAPEHLEIMLDNAISYLPEIKNAGSVFLGRYTPEAVGDYYAGVNHTLPTNQTS 366

Query: 376 ATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
              S+L +  F K+ T  + ++E        I   A  E L AH  +V  R
Sbjct: 367 KFSSALSVDTFVKKSTFVQYTEEMLQKYKDDIVLFAKHEGLDAHARSVQSR 417


>UniRef50_D2RSH8 Histidinol dehydrogenase n=1 Tax=Haloterrigena turkmenica DSM 5511
           RepID=D2RSH8_9EURY
          Length = 432

 Score =  263 bits (671), Expect = 1e-68,   Method: Compositional matrix adjust.
 Identities = 164/404 (40%), Positives = 241/404 (59%), Gaps = 12/404 (2%)

Query: 30  ESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAMA 89
           ++I+  V +I+D V   GD A+RE++++FD   +  + ++ +    A E L  ++++A+ 
Sbjct: 27  DAISDDVREIVDRVHEEGDVAVREFTSEFDDVELGNIDIT-DACERAYEDLEGDVREAIE 85

Query: 90  VAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPA 149
            A  N+  FH AQ       E  PG    +  RP+  VG+Y+PGGSA   S+ +M   PA
Sbjct: 86  TAADNVREFHEAQLPEDWRREFGPGRELGRRFRPIERVGVYVPGGSAAYPSSAIMGVVPA 145

Query: 150 SIAGCKKVVLCSPPPIADEI----LYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDK 205
            +AG   V + +PP  ADE+    L A  + G   V++VGGAQAIA LA+GTE++ +V K
Sbjct: 146 VVAGVDHVAVVTPP--ADELNPVTLAAIHVAGADAVYSVGGAQAIAGLAYGTETITRVQK 203

Query: 206 IFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPD 265
           I GPGN +VT AK  V   ++   ID  AGPSEV+V+AD  A PD VA++L++QAEH P+
Sbjct: 204 IVGPGNKWVTAAKAAVRGDVE---IDFLAGPSEVVVVADETADPDLVAAELVAQAEHDPN 260

Query: 266 SQVILLTPAADMARRVAEAVERQLAELPRAETARQAL--NASRLIVTKDLAQCVEISNQY 323
           + V+ +T  A+ A  VA AV+ Q     R +  R A   +AS +++ + +++ +  + +Y
Sbjct: 261 ASVVAVTDDAETADAVAAAVDGQTEARKREDVIRGAFENDASGVLLARSMSEAILFTEEY 320

Query: 324 GPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGL 383
            PEHL I   +   +++ I SAGSVFLG  +P +AGDYASGTNHVLPT G       L +
Sbjct: 321 APEHLSIIADDEESILERIDSAGSVFLGPNTPVAAGDYASGTNHVLPTNGGARVTGGLSI 380

Query: 384 ADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRV 427
             F +  TVQ LS EG + +  TI TLA AE L AH  +V  R+
Sbjct: 381 ETFLRSTTVQRLSAEGLADIGDTITTLADAEGLEAHAESVRQRL 424


>UniRef50_Q7UX39 Histidinol dehydrogenase n=6 Tax=Planctomycetaceae RepID=HISX_RHOBA
          Length = 460

 Score =  259 bits (663), Expect = 1e-67,   Method: Compositional matrix adjust.
 Identities = 155/398 (38%), Positives = 228/398 (57%), Gaps = 11/398 (2%)

Query: 36  VNDILDNVKARGDEALREYSAKFDKTTVTA--LKVSAEEIAAASERLSDELKQAMAVAVK 93
           V  I  +V+++G EAL  Y+   D   +TA  L+V  E++ AA      +L + +     
Sbjct: 65  VETICKDVQSQGTEALLRYTKSLDGAELTADTLRVPEEDLKAAHAVADPKLIETIGRIRD 124

Query: 94  NIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAG 153
           NI TF +A     V +  +PGV   Q   P+  VG+ +PGG+A   STV+M A PA +AG
Sbjct: 125 NIATFQSAILHRDVTITPRPGVSLTQRYVPIPRVGICVPGGAAAYPSTVMMTAIPAQVAG 184

Query: 154 CKKVVLCSPP-PIA---DEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGP 209
             ++ + +PP P      ++L      G+++V+  GGAQA+AA+A+G +++P VDKI GP
Sbjct: 185 VDEIAVVAPPTPFGAYNTDMLATCHELGIKEVYRCGGAQAVAAMAYGCDALPAVDKIVGP 244

Query: 210 GNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVI 269
           GN FV  AK+ V   +D   ID  AGPSEV+VIAD  A   FVASDLL+QAEH P S  I
Sbjct: 245 GNLFVALAKKHVFGTVD---IDSFAGPSEVIVIADESANAAFVASDLLAQAEHSPGS-AI 300

Query: 270 LLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVEISNQYGPEHL 328
           L+T    +   V   + RQL EL R + AR AL +   L++ +D     E+++ + PEHL
Sbjct: 301 LITWDESLLTSVQAELSRQLGELERGDLARDALSDFGALVLARDADHACELTDSFAPEHL 360

Query: 329 IIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQK 388
            I+TR    L+  I  +G+ FLG  +P + GDYA+G +HVLPT G     + L    F +
Sbjct: 361 QIETREPESLIAKIRHSGAAFLGHHTPVALGDYAAGPSHVLPTGGTCRWAAGLSANSFLR 420

Query: 389 RMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
             +V +  +   SA+A  + T+A  E LTAH  ++++R
Sbjct: 421 SGSVTQFDQSALSAIAQDVITVAEKEGLTAHARSISIR 458


>UniRef50_Q5JFR5 Histidinol dehydrogenase n=9 Tax=cellular organisms
           RepID=HISX_PYRKO
          Length = 376

 Score =  259 bits (662), Expect = 1e-67,   Method: Compositional matrix adjust.
 Identities = 153/400 (38%), Positives = 235/400 (58%), Gaps = 29/400 (7%)

Query: 30  ESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAMA 89
           + +   V +IL++++ RG EALREYS +FD  +    +VS  E   A E + +E K+ + 
Sbjct: 2   KGLEEYVREILEDIRRRGLEALREYSERFDNYS-GPFRVSEGEFEEAEELVPEEDKRVIE 60

Query: 90  VAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPA 149
             ++ +  +H A++   V++  + G     + RP+  +G+Y+PGG  PL ST++M+  PA
Sbjct: 61  ETMERLWEYH-ARQFRDVELYIKRGSLYGLIYRPIGRIGIYVPGGK-PLPSTLMMVGIPA 118

Query: 150 SIAGCKKVVLCSPPP---IADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKI 206
            IAG +++ + +PP    +   +LY A+L G+++V+ +GG  AIAA+A+G   + +VDKI
Sbjct: 119 RIAGVREIAVTTPPKDGKVNPYVLYVAKLLGIEEVYKLGGVGAIAAMAYGV-GMRRVDKI 177

Query: 207 FGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDS 266
           FGPGN FV EAKRQV        ID  AGPSE+ VIAD  A  D+V +DLLSQ EHG DS
Sbjct: 178 FGPGNRFVNEAKRQV---FGIVGIDSLAGPSEIAVIADESADKDYVLADLLSQLEHGKDS 234

Query: 267 QVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQCVEISNQYGPE 326
           +  LLT +            R+LA+      +R+ +    +++ ++L +C E +N+  PE
Sbjct: 235 KAWLLTTS------------RELADY----CSREGIE---VLLCRNLEECAEKANEIAPE 275

Query: 327 HLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADF 386
           HL I T N  ELVD I +AG+++LG ++P  A DY  G NHVLPT G       L + DF
Sbjct: 276 HLEIITENPEELVDLIENAGAIYLGPYTPVPAADYFLGVNHVLPTGGAARFSGVLTVMDF 335

Query: 387 QKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
            K +T+  +S+E F A       LA  E + AH+ ++ +R
Sbjct: 336 MKPITLARVSREEFLAYRRLGMRLAEIEGMEAHRRSLEVR 375


>UniRef50_Q67KH6 Histidinol dehydrogenase n=1 Tax=Symbiobacterium thermophilum
           RepID=HISX_SYMTH
          Length = 439

 Score =  258 bits (659), Expect = 3e-67,   Method: Compositional matrix adjust.
 Identities = 163/401 (40%), Positives = 231/401 (57%), Gaps = 14/401 (3%)

Query: 36  VNDILDNVKARGDEALREYSAKFDKTTV--TALKVSAEEIAAASERLSDELKQAMAVAVK 93
           V  IL+ V+  GD AL  ++ +FD   +  T L+V+  E   A   +S   + A+ VAV+
Sbjct: 29  VRAILERVRREGDGALYAFTRQFDGADLEATGLRVTEAEYREAEAAVSAAFRAALQVAVE 88

Query: 94  NIETFHTAQKLPPVDVETQP-GVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIA 152
           NI  FH  Q +P     T+P G    Q   PV   G+Y+PGGSAPLFS +LM A PA +A
Sbjct: 89  NIAAFHRPQ-VPTSWFTTRPDGTIVGQRVTPVDRAGVYVPGGSAPLFSCLLMTAIPAVVA 147

Query: 153 GCKKVVLCSPPP----IADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFG 208
           G  +V++C+PP     I   +L AA+  GV+DV+ VGGAQAI A+A+GT +VP+VDKI G
Sbjct: 148 GVPEVIVCTPPDRNGRIDPHMLVAARAAGVKDVYKVGGAQAIGAMAYGTATVPRVDKIAG 207

Query: 209 PGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQV 268
           PGN +VT AK+ V        IDM AGP+EV+ + D     +++A+DLLSQAEH P+  V
Sbjct: 208 PGNYYVTLAKKLV---FGPVGIDMLAGPTEVMAVDDGSVDAEWLAADLLSQAEH-PNGMV 263

Query: 269 ILLTPAA-DMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVEISNQYGPE 326
           IL+T A  +    V  A+ R  A LPRAET R+++      +    L +  ++ N  GPE
Sbjct: 264 ILVTTAGPERIAAVGAAMARHTAALPRAETIRRSVAELGAALAVDTLEEAADLVNAVGPE 323

Query: 327 HLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADF 386
           HL +   +    +  +  AGS+FLG W+PE+ GDY +G ++V+PT G     S + +  F
Sbjct: 324 HLEVGVADPWAFLPLVRHAGSIFLGRWTPEAMGDYIAGPSNVIPTEGTARYASPVCVETF 383

Query: 387 QKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRV 427
            KR  V   S+  F A A     LA  E L AH  ++ +R+
Sbjct: 384 IKRSAVTCYSEAAFRAQAPHAVRLALTEDLLAHAASMQIRL 424


>UniRef50_D1B7M0 Histidinol dehydrogenase n=2 Tax=Bacteria RepID=D1B7M0_THEAS
          Length = 424

 Score =  257 bits (656), Expect = 7e-67,   Method: Compositional matrix adjust.
 Identities = 163/407 (40%), Positives = 232/407 (57%), Gaps = 19/407 (4%)

Query: 32  ITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAMAVA 91
           ++  V  I+D V   GD A+ E S   D+++  ++ V  EE+  A   +  EL +A+  A
Sbjct: 21  VSHEVRRIIDWVVLHGDRAVLEGSRLHDRSSRDSILVPVEELQRAHRSMDPELLEAVRYA 80

Query: 92  VKNIETFHTAQK---LPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATP 148
             N+ETF   QK   +P  + E + GV       PV S G+YIPGGS PL ST +MLA P
Sbjct: 81  ASNVETFAQRQKGALMPLEESEVRDGVYLGHRVVPVDSCGIYIPGGSYPLISTAVMLAVP 140

Query: 149 ASIAGCKKVVLC--------SPPPIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESV 200
           A +AG  ++  C        SP P     LY     GV +V+  GGA A+AA+A GTES+
Sbjct: 141 ARVAGVGRICACTPVRRGTNSPDPSVLGTLYE---LGVTEVYAAGGAYAVAAMAHGTESI 197

Query: 201 PKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQA 260
           P VD I GPGN +VTEAKRQ   ++    ID  AGPSEVL+IA  G  PDF+A DLL+QA
Sbjct: 198 PPVDVIVGPGNKYVTEAKRQCFGKV---GIDFVAGPSEVLIIAQEG-DPDFIAWDLLAQA 253

Query: 261 EHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVEI 319
           EH PD++ +L+T +  +AR+V + VE  L E+  +  AR +  +   ++  + + + VE 
Sbjct: 254 EHDPDAKGVLVTTSPALARQVMDRVETILGEIVTSPVARSSWEDHGEVLAAEGMDEAVEF 313

Query: 320 SNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCS 379
           SN+  PEHL +  ++    +  + + G++F+G+ S E  GDYASG+NH LPT G +    
Sbjct: 314 SNRMAPEHLELMVQDPDRWIPRLRNYGALFIGEHSAEVFGDYASGSNHTLPTAGASRYTG 373

Query: 380 SLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
            L +  F K +T Q +++EG   LA     LA AE L AH+ A   R
Sbjct: 374 GLWVGTFLKVLTSQRVTREGARELARVSALLAQAEGLMAHRGAALAR 420


>UniRef50_C7LV94 Histidinol dehydrogenase n=6 Tax=Desulfovibrionales
           RepID=C7LV94_DESBD
          Length = 436

 Score =  256 bits (655), Expect = 8e-67,   Method: Compositional matrix adjust.
 Identities = 160/437 (36%), Positives = 237/437 (54%), Gaps = 19/437 (4%)

Query: 1   MSFNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDK 60
           + + +  DW +  +   R+       +  +++   V DIL  V+ RGDEA+ EY+ +FD 
Sbjct: 6   LEYTSPNDWTAIASWMARR------DAGEDNVEPLVRDILAQVRERGDEAVAEYTRRFDC 59

Query: 61  TTVTA--LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQ 118
            +++A  L V   +I  A E +  E    +  A  NI  FH  QK         PG    
Sbjct: 60  PSLSAAGLPVPKADIGRALELIPAEDAAIIREAAANIRDFHLRQKQNSWITTPAPGTTLG 119

Query: 119 QVTRPVASVGLYIPGGSA---PLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILY 171
           Q+  PV   GLY+PGG     PL S++LM A PA +AG   + + SPP     +   IL 
Sbjct: 120 QLVLPVDRAGLYVPGGQGGETPLISSLLMNAIPAQVAGVGAICVVSPPRKDGTLNPYILA 179

Query: 172 AAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAID 231
            A + G+  +F  G A AIAALA+GT S+P+VD I GPGN FVT AKR +  ++    ID
Sbjct: 180 TAAILGIDTIFMCGSAWAIAALAYGTASIPRVDVIAGPGNIFVTTAKRLLVGQV---GID 236

Query: 232 MPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAE 291
           M AGPSE+ ++ADS A P ++A+D+LSQAEH P +  IL++    +   V + + RQL  
Sbjct: 237 MIAGPSEIAILADSTANPKWLAADMLSQAEHDPLASSILISADQQLLEEVKKELARQLPA 296

Query: 292 LPRAETARQALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFL 350
           LPR E A ++L+  S LI   DL   +++ N+  PEH  +   +   LV ++ +AG+VF+
Sbjct: 297 LPRQEIASKSLSEWSALIHVPDLEMGMDLINRLAPEHFELSVADPWALVGAVRNAGAVFM 356

Query: 351 GDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETL 410
           G  +PE  GDY +G NHVLPT       S+L +  F K+ ++    +   ++  S +  L
Sbjct: 357 GHSTPEPVGDYFAGPNHVLPTLSTARFSSALSVDTFCKKTSLICTDQAYMNSHGSKVARL 416

Query: 411 AAAERLTAHKNAVTLRV 427
           A  E L AH  +V  R+
Sbjct: 417 ARLEGLEAHARSVEQRL 433


>UniRef50_C4L171 Histidinol dehydrogenase n=1 Tax=Exiguobacterium sp. AT1b
           RepID=C4L171_EXISA
          Length = 405

 Score =  256 bits (653), Expect = 2e-66,   Method: Compositional matrix adjust.
 Identities = 151/406 (37%), Positives = 243/406 (59%), Gaps = 14/406 (3%)

Query: 27  SASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLS-DELK 85
           S  E+    V  I+++++ARGDEAL +++ +FD       ++ + ++A+ +  ++  EL 
Sbjct: 8   SRREAWAEAVKPIVESIEARGDEALLKWTKQFDGVD----RIESVDLASFNPPVAYAELT 63

Query: 86  QAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLML 145
           +A+++A + I TFH A+++   DV      R  +   P+ SVG+Y+PGG+A   S+VLM 
Sbjct: 64  EALSLAAERIRTFH-ARQVRQDDVFEDTMFRLGRRYMPLDSVGVYVPGGTAVYPSSVLMN 122

Query: 146 ATPASIAGCKKVVLCSPPP---IADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPK 202
             PA +AG K+VV+ +PP    I   +L AA++ G  + F +GGAQA+AALA+GTE++  
Sbjct: 123 IIPAKVAGVKRVVMVTPPKADGIDISLLIAAKIAGADECFLIGGAQAVAALAYGTETIRP 182

Query: 203 VDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEH 262
           VDKI GPGNA+V  AK  VS  +    ID  AGPSEVL+IAD  A P +VA+DLL+QAEH
Sbjct: 183 VDKIVGPGNAYVATAKALVSHIV---GIDSVAGPSEVLIIADETANPKWVAADLLAQAEH 239

Query: 263 GPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQCVEISNQ 322
             ++  I +  +  +  ++ + +ERQL +LPR + AR++L     ++ + +   +E +N 
Sbjct: 240 DVEATAIAIVTSETLRDQIEQELERQLVQLPRQDIARESLKRGG-VLYRTIEDAIEYANT 298

Query: 323 YGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLG 382
              EH+ +  ++   L+ +I   GS FLG  + E+ GDY +G NHVLPT G     S L 
Sbjct: 299 MAAEHVQLAVKDPEVLMRAIRHGGSFFLGHEAAEAFGDYIAGPNHVLPTSGTARFSSGLS 358

Query: 383 LADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVN 428
           + DF +R T  E+++   +   + I  +A  E+L  H  A+ +R+ 
Sbjct: 359 VDDFYRRQTFLEMTELDETITKAAIR-IAKQEQLEGHARAMAVRME 403


>UniRef50_A9A5X6 Histidinol dehydrogenase n=2 Tax=Thaumarchaeota RepID=A9A5X6_NITMS
          Length = 420

 Score =  255 bits (652), Expect = 2e-66,   Method: Compositional matrix adjust.
 Identities = 149/414 (35%), Positives = 234/414 (56%), Gaps = 10/414 (2%)

Query: 19  QLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASE 78
           Q L +     S    + V  IL +VK  GD A+++Y  KF    V++L+VS  +IA+A  
Sbjct: 11  QFLKKIGTKDSSKNQKIVKSILKDVKKNGDVAVKKYEKKFS-AKVSSLRVSQRDIASAYF 69

Query: 79  RLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQP-GVRCQQVTRPVASVGLYIPGGSAP 137
           ++S E   A+ +A   +    +A +    D+  +  G +  +   P+ SVG Y+PGG+A 
Sbjct: 70  KVSKEDISAIKLAKSRLSKAESAVRRQFKDITIKSNGTKLSKSFVPIDSVGCYVPGGAAR 129

Query: 138 LFSTVLMLATPASIAGCKKVVLCSPPPIADEI----LYAAQLCGVQDVFNVGGAQAIAAL 193
             S+ +M   PA IAG K++V+ SPP  +  I    + AA LCG  +++  GG Q+IAAL
Sbjct: 130 YPSSAIMSVVPAKIAGVKRIVVVSPPNSSGNIDPLTIVAADLCGATEIYKTGGVQSIAAL 189

Query: 194 AFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVA 253
            +GT S+ KV+KI GPG AFVT AK  VS  +   +IDM AGP+E+ ++ DS A  D  A
Sbjct: 190 TYGTRSIKKVNKIVGPGGAFVTLAKYLVSNIV---SIDMMAGPTELGIVIDSAADVDVAA 246

Query: 254 SDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDL 313
            DL+SQAEH  D+    LT +  +A+++  +V  +L ++ R +  + +L ++  I     
Sbjct: 247 LDLISQAEHSSDTFCYALTTSNSIAKKIQSSVNSKLKDIQRVKIVKSSLESNGFIGVCKP 306

Query: 314 AQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYG 373
           +  ++I+N   PEHL I ++N ++  + I + G +  G  SP SA DY  G+NH+LPT G
Sbjct: 307 SDIIDIANDLAPEHLEIISKNPKKW-NKIKNPGLILYGKNSPSSASDYLLGSNHILPTNG 365

Query: 374 YTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRV 427
           +  T  SL + DF K +T  E +K+    ++ +++ L  AE L  H  AV  R+
Sbjct: 366 FGKTRGSLSVLDFVKLLTKIETTKKDLQKISKSMKNLTLAEGLPNHYEAVRGRL 419


>UniRef50_C3XDE7 Histidinol dehydrogenase n=1 Tax=Helicobacter bilis ATCC 43879
           RepID=C3XDE7_9HELI
          Length = 452

 Score =  255 bits (651), Expect = 2e-66,   Method: Compositional matrix adjust.
 Identities = 156/452 (34%), Positives = 241/452 (53%), Gaps = 28/452 (6%)

Query: 6   IIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDK---TT 62
           I++ +    E +   L+  A +  +SI   V   L ++K RG++AL +   K+D     T
Sbjct: 4   ILNIHDKDFETEFNTLLARANTDMDSIIPEVLKTLQDIKQRGEDALLDIVRKYDSWNPQT 63

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
              LK++ E+   A + L  + K A+ +A   I TFH            +      Q   
Sbjct: 64  FNDLKIAEEDTFNAYKNLDSKTKDALQIAHDRIYTFHAKNAPKGFIYHDEYANMLGQNIM 123

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCGVQ 179
           P+   G+YIPGG A   S++LM A PA +AG K++++ SP P   I + +L A  LCG++
Sbjct: 124 PIQRAGIYIPGGKAFYPSSLLMNAIPAKVAGVKEIIMASPTPNNHINELVLAAMYLCGIK 183

Query: 180 DVFNVGGAQAIAALAFG------------------TESVPKVDKIFGPGNAFVTEAKRQV 221
           + + +GG  AI   A+G                   +   KVD I GPGN +V  AK+ V
Sbjct: 184 EGYKIGGIGAIGMFAYGFGETKWSKDSLFSHTKTTQKGFKKVDVITGPGNIYVATAKKLV 243

Query: 222 SQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRV 281
              ++   IDM AGPSE+ +IADS A  D++A D+LSQAEH   +  IL+T   D+A+ V
Sbjct: 244 FGEVN---IDMIAGPSEIGIIADSHANSDYLAIDMLSQAEHDSMASAILITDNKDLAKEV 300

Query: 282 AEAVERQLAELPRAETARQALNA-SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVD 340
           A+ ++ +L  L R + A++++     +I+ ++L Q   + N   PEHL I T+    L+ 
Sbjct: 301 AQKIDTKLTHLMRKDIAQKSIQERGAIIIVENLKQAAMLMNAIAPEHLEIVTQEPFSLLG 360

Query: 341 SITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGF 400
            I +AG+VFLG ++PE+ GDY +G NH LPT G     S LG+  F  R ++   SK+G 
Sbjct: 361 EIKAAGAVFLGHYTPEAIGDYLAGPNHTLPTGGSARFFSPLGVEHFCTRSSLISFSKQGI 420

Query: 401 SALASTIETLAAAERLTAHKNAVTLRVNALKE 432
             LA+    LA  E L AHK +V  R++++K+
Sbjct: 421 KNLANPCAILAETEGLEAHKLSVISRLDSMKD 452


>UniRef50_Q3AR25 Histidinol dehydrogenase n=13 Tax=Bacteria RepID=HISX_CHLCH
          Length = 428

 Score =  254 bits (650), Expect = 4e-66,   Method: Compositional matrix adjust.
 Identities = 154/423 (36%), Positives = 231/423 (54%), Gaps = 11/423 (2%)

Query: 13  TAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEE 72
           +A Q+R  L+R  +S  E+  + V++IL  V+ +GD A+  Y+ +F    +T+++V  E 
Sbjct: 12  SALQER--LVR-HVSFDEAAHKAVDEILAKVRQQGDRAVLNYTEQFQGVRLTSMQVDEEA 68

Query: 73  IAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIP 132
           I  A       L   +  A  NI  FH  +       E + GV   Q  RP+    LY+P
Sbjct: 69  IEMAYRHADPSLIATLHEAYANIVRFHEHEVERSFFYEAEGGVLLGQRVRPMERAMLYVP 128

Query: 133 GGSAPLFSTVLMLATPASIAGCKKVVLCSP----PPIADEILYAAQLCGVQDVFNVGGAQ 188
           GG A   S++LM A PA +AG  ++ + +P      +   IL AA++ G+  ++ +GGAQ
Sbjct: 129 GGKAAYPSSLLMNAAPAKVAGVCEIAVTTPCDATGVVNPTILAAAKVAGISSIYKIGGAQ 188

Query: 189 AIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGAT 248
           A+AA A+GTES+PKVD I GPGN +V  AK+QV       AID  AGPSEV++IAD  A 
Sbjct: 189 AVAAFAYGTESIPKVDIITGPGNKYVALAKKQV---FGHVAIDSIAGPSEVVIIADESAH 245

Query: 249 PDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAET-ARQALNASRL 307
            +FVA D+ +QAEH PD+  +L+T +   A+ V +AV   L  + R ET A   L+   +
Sbjct: 246 AEFVALDMFAQAEHDPDASAVLITTSESFAQAVQQAVASLLPTMLRHETIASSLLHNGAM 305

Query: 308 IVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNH 367
           ++   L     +S+   PEHL +      +++  +  AG++F+G +S E+ GDY +G NH
Sbjct: 306 VLVPSLDDACAVSDMLAPEHLELHVVQPWDILPKLKHAGAIFMGSYSCETIGDYFAGPNH 365

Query: 368 VLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRV 427
            LPT G     S L + DF K  ++   S E   +  + I   A AE L AH  AV +R+
Sbjct: 366 TLPTSGTARFFSPLSVRDFVKHTSIISYSPEQLRSKGAQIAAFADAEGLQAHAEAVRVRL 425

Query: 428 NAL 430
             L
Sbjct: 426 KTL 428


>UniRef50_Q1AX10 Histidinol dehydrogenase n=1 Tax=Rubrobacter xylanophilus DSM 9941
           RepID=Q1AX10_RUBXD
          Length = 418

 Score =  253 bits (647), Expect = 7e-66,   Method: Compositional matrix adjust.
 Identities = 160/424 (37%), Positives = 229/424 (54%), Gaps = 20/424 (4%)

Query: 7   IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTAL 66
           +D     A +  + L RP    S  +   V  +++ V+ RGDEAL EY  +FD      L
Sbjct: 5   LDARGLDAREVVRRLRRPRGFLSREVRAAVRQVVEEVRERGDEALLEYGERFDGVRPDPL 64

Query: 67  KVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVAS 126
           +V  EEI  A   L  EL +A   A++N+  FH  +     ++E + G R  Q  RP+  
Sbjct: 65  RVPREEIERARAALPGELAEAFRTAIENVRRFHERELDRSWELE-RGGARLGQRVRPLRR 123

Query: 127 VGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQDVF 182
            G+Y+PGG     ST++M A PA +AG +++ +C+PP         +L  A L G+ +V+
Sbjct: 124 AGIYVPGGHGAYPSTLVMTAVPAQVAGVEELCVCTPPGPDGRANPRLLAVAGLLGIGEVY 183

Query: 183 NVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVI 242
             GGAQA+AA+AFGTESVP+VDKI GPGN +VT AK +V        +D P GPSE++V+
Sbjct: 184 AAGGAQAVAAMAFGTESVPRVDKIVGPGNDYVTAAKLEV---FGEVGVDAPQGPSELVVV 240

Query: 243 ADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL 302
           AD  A P+ VA DL++QAEH   +  +LLTP+  +A      VE  L+  P         
Sbjct: 241 ADGSARPERVALDLMAQAEHLSGATSVLLTPSGALA----SGVEPLLSGRPSEHIT---- 292

Query: 303 NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYA 362
               L++ +DL Q +EISN Y PEH+ +    A   ++ + +AG V +GD SP +  DYA
Sbjct: 293 ----LVLVRDLEQALEISNLYAPEHVHLNCEGAGAALERVEAAGLVAVGDLSPVALSDYA 348

Query: 363 SGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNA 422
           +G +H LPT G     S+LG  DF  R+     S+E    L   +E LA  E    H  +
Sbjct: 349 AGPSHALPTGGTARWASALGTHDFLTRINHMRFSREALRELGPHVERLARMEGFENHAAS 408

Query: 423 VTLR 426
           V  R
Sbjct: 409 VAAR 412


>UniRef50_Q5WIU9 Histidinol dehydrogenase 1 n=52 Tax=cellular organisms
           RepID=HISX1_BACSK
          Length = 424

 Score =  253 bits (645), Expect = 1e-65,   Method: Compositional matrix adjust.
 Identities = 149/405 (36%), Positives = 220/405 (54%), Gaps = 11/405 (2%)

Query: 31  SITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAMAV 90
            + +TV  ++  ++  G+ A+RE S +FD       ++SAEEI      + D++K  +  
Sbjct: 20  KVEQTVASLIARIEKEGETAVRELSRQFDNWDPEQFRLSAEEIEKIVRSVPDQVKADICF 79

Query: 91  AVKNIETFHTAQK--LPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATP 148
           A + I  F   Q+  +  ++VET+PGV       PV SVG YIPGG  P+ ++  M    
Sbjct: 80  AQEQIRHFAEQQRASIQDIEVETRPGVFLGHKNIPVNSVGCYIPGGRYPMVASSHMSILT 139

Query: 149 ASIAGCKKVVLCSPPPIADEI----LYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVD 204
           A +AG K+V+ C+PP I  EI    + A    G  +++ +GG QA+ A+A GTE++  VD
Sbjct: 140 AKVAGVKRVIGCTPP-INGEIPAATVTAMHFAGADEIYILGGVQAMTAMAVGTETIEAVD 198

Query: 205 KIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGP 264
            + GPGNAFV EAKRQ+  R+    ID+ AGP+EVL+IAD  A  + VA+DLL QAEHGP
Sbjct: 199 MLVGPGNAFVAEAKRQLFGRV---GIDLFAGPTEVLIIADDTADGEMVATDLLGQAEHGP 255

Query: 265 DSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIV-TKDLAQCVEISNQY 323
            S   L+T +  +A      +ERQL  LP A+ A+ A     +I+   DLA+ V  +++ 
Sbjct: 256 TSPAALITTSKKLAEETVAEIERQLQTLPTADVAKVAWEEHGMIILVDDLAEAVVEADKL 315

Query: 324 GPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGL 383
             EH+ + T N    +D +T+ G++FLG  +  + GD   GTNH LPT         L +
Sbjct: 316 AYEHVQVLTENPNYFLDHMTNYGALFLGPETNVAYGDKVIGTNHTLPTKKAAKYTGGLWV 375

Query: 384 ADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVN 428
             F K  T Q  + E  + +    E L   E    HK   +LRV 
Sbjct: 376 GKFLKNCTYQRCTPEASAEIGRIAERLCELEGFIGHKAQASLRVK 420


>UniRef50_Q3B5E3 Histidinol dehydrogenase n=8 Tax=Chlorobiaceae RepID=HISX_PELLD
          Length = 443

 Score =  252 bits (644), Expect = 2e-65,   Method: Compositional matrix adjust.
 Identities = 151/402 (37%), Positives = 223/402 (55%), Gaps = 8/402 (1%)

Query: 32  ITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAMAVA 91
           + R V DIL+ V+ RGD A+ EY+ +F    +T+++V  E+I  A E       + +  A
Sbjct: 43  VQRAVTDILEAVRLRGDMAVLEYTERFQGAVLTSMQVPEEDILRAREEADPAFIRVLEEA 102

Query: 92  VKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASI 151
            +NI  FH  +       E + GV   Q   P+    LY+PGG A   S+VLM A PA +
Sbjct: 103 WENILRFHRHEVENSFFYEGEGGVVLGQRVTPMDRAMLYVPGGKASYPSSVLMNAAPARV 162

Query: 152 AGCKKVVLCSP----PPIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIF 207
           AG  ++ + +P      ++  IL AA + GV  V+ +GGAQA+AA A+GT+++PKVD I 
Sbjct: 163 AGVGEIFMTTPCDASGAVSPHILAAASVAGVTSVYRLGGAQAVAAFAYGTQTIPKVDIIT 222

Query: 208 GPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQ 267
           GPGN +V  AK+QV       AID  AGPSEV+V+AD  A  +F+  DL +QAEH PD+ 
Sbjct: 223 GPGNKYVALAKKQV---FGHVAIDSIAGPSEVVVVADDDADAEFITMDLFAQAEHDPDAS 279

Query: 268 VILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVEISNQYGPE 326
            +L+TP+  +A  V +    ++  + R E   +AL N   ++V  D+ +   +S+   PE
Sbjct: 280 SVLITPSMRLAEEVRDLAAARVGSMLRGEVIAEALSNNGAIVVVADIEEACRVSDMIAPE 339

Query: 327 HLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADF 386
           HL +   +  EL+ SI  AG+VF+G +S E+ GDY +G NH LPT G     S L + DF
Sbjct: 340 HLELHVLHPWELLASIRHAGAVFMGGYSCETVGDYYAGPNHTLPTNGTARFFSPLSVRDF 399

Query: 387 QKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVN 428
            K  ++   ++    A    I + A  E L AH  AV  R+ 
Sbjct: 400 VKHTSIISYTRRQIMACGERIASFADHEGLEAHAEAVRARLK 441


>UniRef50_Q4FNE2 Histidinol dehydrogenase 1 n=3 Tax=Candidatus Pelagibacter
           RepID=HISX1_PELUB
          Length = 428

 Score =  252 bits (644), Expect = 2e-65,   Method: Compositional matrix adjust.
 Identities = 143/397 (36%), Positives = 234/397 (58%), Gaps = 8/397 (2%)

Query: 35  TVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAMAVAVKN 94
           +V  I+ +VK  GD+A+ +Y  +F+K ++ A   S ++I  A + L  ++K+A+ +A   
Sbjct: 33  SVIKIIKDVKKNGDKAILKYEKRFNKNSIIA--PSIKQINRAIQSLDQKVKKAIDLAYDR 90

Query: 95  IETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGC 154
           I  FH+ QK   +    +   + +    P+ SV +Y+PG +A   S+VLM A PA +AG 
Sbjct: 91  IYKFHSLQKFKNISYTDKLKNKLEYKYVPIESVAIYVPGSTASYPSSVLMNAVPAIVAGV 150

Query: 155 KKVVLCSPPPIADE---ILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGN 211
           K++V+ +P     +   +LYAA+ C +++++++GG  AIAA+A+GT+ + KVDKI GPGN
Sbjct: 151 KRLVMVNPGQKGKQNPAVLYAAKKCKIKEIYSIGGPSAIAAVAYGTKKIKKVDKIIGPGN 210

Query: 212 AFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILL 271
           ++V  AK++V    D     M AGPSEV ++ D  + P+++ASDL+ QAEH   +Q IL+
Sbjct: 211 SYVAAAKKEVFG--DVGIEGMIAGPSEVTIVCDKFSNPEWIASDLIGQAEHDNLAQCILI 268

Query: 272 TPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVEISNQYGPEHLII 330
           +    + ++V   +  QL ELPRA  A+ +L N   LI      + +   N+  PEHL +
Sbjct: 269 SKDKSIIKKVNYEIINQLKELPRAVIAKNSLLNNGILIYMPSDQKIINTVNKIAPEHLEL 328

Query: 331 QTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRM 390
            T+N +++V  I +AGS+ LG ++  +  DY  G+NHVLPT       S + + +F KR+
Sbjct: 329 NTKNYKKVVSKIKNAGSICLGKYAVMAMTDYNVGSNHVLPTNSSARYSSGVSVNEFYKRI 388

Query: 391 TVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRV 427
           +   LSK+G   L  ++ TLA  E L  H  +V  R+
Sbjct: 389 SYINLSKKGIETLGPSVITLANYEGLVGHAKSVEKRI 425


>UniRef50_B0S9F2 Histidinol dehydrogenase n=6 Tax=Leptospira RepID=HISX_LEPBA
          Length = 430

 Score =  250 bits (638), Expect = 9e-65,   Method: Compositional matrix adjust.
 Identities = 168/424 (39%), Positives = 239/424 (56%), Gaps = 16/424 (3%)

Query: 18  RQLLMRPAISASESITRTVNDIL---DNVKARGDEALREYSAKFDKTTVTALKVSAEEIA 74
           ++L  R    A E +T   + IL   ++V+ +GD+AL  Y+  FD   ++ L +  ++I 
Sbjct: 13  KELYSRFLQGAREDLTTATDRILPILESVRTQGDQALFSYTEMFDGIKLSQLTIDPKKIK 72

Query: 75  AASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGG 134
                + ++ K+A   A  NIE FH  QK      +   G R      P+ S+ +Y PGG
Sbjct: 73  T---NVDEKTKEAFLRAKSNIEAFHMEQKRESWS-KVIDGNRLGVKYTPIPSLAVYAPGG 128

Query: 135 SAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCGVQDVFNVGGAQAIA 191
            A   S+VLM   PA IAG   + L +PP    I + +++ AQ+  +  +  VGGAQ IA
Sbjct: 129 KALYPSSVLMGIIPAKIAGVPSIQLITPPQKDGIPEILVWLAQIMDIDRIVTVGGAQGIA 188

Query: 192 ALAFGTESVPKVDKIFGPGNAFVTEAKRQVS-QRLDGAAIDMPAGPSEVLVIADSGATPD 250
           A A+GTESVPK + I GPGNA+V  AK  +S Q L G  I+ PAGPSEV +IAD  A P 
Sbjct: 189 AAAYGTESVPKSEFIVGPGNAYVAAAKSYLSGQGLIG--IESPAGPSEVCIIADENANPK 246

Query: 251 FVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQA--LNASRLI 308
           ++A D+LSQAEHG DS  ILLT    +A+RV+E +E   +E P+    +Q      S ++
Sbjct: 247 WIACDMLSQAEHGEDSSAILLTTDLTLAKRVSEELEIAFSERPKRLQMKQTAIYENSSIL 306

Query: 309 VTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHV 368
           V   L  C+  SN+  PEHL IQT++   +   I  AGSVFLG +SP + GDY SGTNH+
Sbjct: 307 VFPTLDDCIWFSNELAPEHLEIQTKDYESVFAKIEHAGSVFLGPYSPVAMGDYISGTNHI 366

Query: 369 LPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERL-TAHKNAVTLRV 427
           LPT   +   SSLG+  F KR+T QE++KE    L   ++ ++  E L   H  +V +R 
Sbjct: 367 LPTARGSRIYSSLGVDTFLKRVTFQEVTKESLENLYPFVKLMSELEGLDEEHGTSVKVRT 426

Query: 428 NALK 431
              +
Sbjct: 427 RQFQ 430


>UniRef50_C9SQK1 Histidine biosynthesis trifunctional protein n=1 Tax=Verticillium
           albo-atrum VaMs.102 RepID=C9SQK1_VERA1
          Length = 699

 Score =  249 bits (635), Expect = 2e-64,   Method: Compositional matrix adjust.
 Identities = 156/433 (36%), Positives = 221/433 (51%), Gaps = 79/433 (18%)

Query: 8   DWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALK 67
           D +  +A +  ++L RP+  + E+I   V  I+D V++ GD+A+  Y+ KF+K T     
Sbjct: 339 DASKVSAAEVTEVLKRPSQKSPEAILNIVKPIIDEVRSGGDKAVLSYTHKFEKATSLTSP 398

Query: 68  VSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKL-PPVDVETQPGVRCQQVTRPVAS 126
           V        + +LS E  +A+ ++ +NI  FH AQK   P+ VET PGV C +++RP+  
Sbjct: 399 VLRAPFPEEAMKLSKESIKAIDISFENIRKFHAAQKEDKPLHVETMPGVVCSRMSRPIER 458

Query: 127 VGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQDVF 182
           VGLYIPGG+A L ST LML  PA +AGCKK+V  SPP     +  EI+Y A   G + + 
Sbjct: 459 VGLYIPGGTAVLPSTALMLGVPAMVAGCKKIVFASPPRADGSLTPEIVYVAHKVGAESIV 518

Query: 183 NVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLD-GAAIDMPAGPSEVLV 241
             GGAQA+AALA+GTESVPKVDKI GPGN FVT AK  VS   + G +IDMPAGPSEV  
Sbjct: 519 LAGGAQAVAALAYGTESVPKVDKILGPGNQFVTAAKMFVSNDTNAGVSIDMPAGPSEVRD 578

Query: 242 IADS-GATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQ 300
           I ++   + D+    L+ Q ++ P                               E A+ 
Sbjct: 579 IDEAMRISNDYAPEHLILQLKNAP-------------------------------EVAQM 607

Query: 301 ALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGD 360
            +NA  + +            ++ PE                       +GD        
Sbjct: 608 VMNAGSIFI-----------GEWTPES----------------------VGD-------- 626

Query: 361 YASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHK 420
           Y++G NH LPTYG+    S + L  F K +T   L+ EG   + S +  LA  E L AH+
Sbjct: 627 YSAGVNHSLPTYGFAKQYSGVNLGSFVKHITSSNLTAEGLRNVGSAVMQLAKVEELEAHR 686

Query: 421 NAVTLRVNALKEQ 433
            AV +R+N L ++
Sbjct: 687 RAVEIRLNYLDKK 699


>UniRef50_Q483H8 Histidinol dehydrogenase 2 n=15 Tax=Proteobacteria
           RepID=HISX2_COLP3
          Length = 446

 Score =  247 bits (631), Expect = 6e-64,   Method: Compositional matrix adjust.
 Identities = 151/435 (34%), Positives = 235/435 (54%), Gaps = 20/435 (4%)

Query: 13  TAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA--LKVSA 70
           +AEQ+ +LL R   S  ++    V  I++NVK  GD+AL EY+ KFDK  V+   ++V+ 
Sbjct: 14  SAEQRNKLLQRTE-SNLDNFIDIVKPIIENVKLNGDKALSEYAKKFDKAEVSTDQIQVTQ 72

Query: 71  EEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDV---ETQPGVRCQQVTRPVASV 127
            E   A   + +E+ Q ++ ++ NI+ FH AQ   P ++   + +PG        P+ +V
Sbjct: 73  AEFDEAFTLVDEEVIQTLSYSIDNIKKFHEAQM--PEEMWMKQIRPGCYAGDRFTPINAV 130

Query: 128 GLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEI----LYAAQLCGVQDVFN 183
             YIP G     S  +M A PA +AG    ++ +PP    ++    L  A+L G+  VF 
Sbjct: 131 ACYIPRGKGSFPSVAIMTAVPAIVAGVPTAIIITPPGTDGKVDAATLVVAKLVGIDKVFK 190

Query: 184 VGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIA 243
            GGAQ IAA+A+GT +VPK DK+ GPG+ FV  AK+ ++  +       PAGPSE +V+A
Sbjct: 191 CGGAQGIAAVAYGTNTVPKCDKVVGPGSPFVVAAKKLLADIIHPGT---PAGPSEAIVLA 247

Query: 244 DSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPR--AETARQA 301
           D  A P   A DLL +AEHGPDS   L+T + ++A +   A+      + R   + +   
Sbjct: 248 DDTANPKLAALDLLVEAEHGPDSSAFLVTNSKELAEQAQVAINEYWQHMDRLRVDFSSTV 307

Query: 302 LNASR--LIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAG 359
           L+     +++T    + V+  N Y  EHL+I +++  + +  I +AG + LG+ +P S  
Sbjct: 308 LSGDNGGIVLTSTFEEAVDFCNDYAAEHLLILSKSPFDHLGKIINAGEILLGENTPISIA 367

Query: 360 DYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAH 419
           +Y  G N VLPT     T S L + D+ K  ++  L++EG+  LA      A  E   AH
Sbjct: 368 NYTLGPNAVLPTSMAAKTASPLSVFDYLKSCSIGYLTREGYEELAPHTYRFAKYEGFDAH 427

Query: 420 KNAVT-LRVNALKEQ 433
            NAV+ LR  A+K +
Sbjct: 428 ANAVSHLRDEAIKSE 442


>UniRef50_O33775 Histidinol dehydrogenase n=12 Tax=Sulfolobaceae RepID=HISX_SULSO
          Length = 398

 Score =  244 bits (622), Expect = 6e-63,   Method: Compositional matrix adjust.
 Identities = 142/399 (35%), Positives = 221/399 (55%), Gaps = 29/399 (7%)

Query: 35  TVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAMAVAVKN 94
            V DI+++VK +GD AL E + K DK  +  +K   EE+   + +L  ++KQA+  A + 
Sbjct: 20  VVKDIIESVKTKGDNALYELTEKLDKVKIDNIKAREEELKTQASKLDPKVKQAIDTAYEQ 79

Query: 95  IETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGC 154
           ++ FH    +PP       G+    + R +  +G+Y+P G     ST+LM   PA +A  
Sbjct: 80  LKAFHEML-VPPNIGGGYQGISFGVIWRSIEKIGIYVPSGKYSYPSTLLMAGIPAKVAKV 138

Query: 155 KKVVLCSPPP----IADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPG 210
           K++ + SPP     +   + Y A   GV +V+ +GGAQAIAALAFGTESV KV KI GPG
Sbjct: 139 KEIYVASPPTQEGTVNPALAYVAIKLGVNEVYKIGGAQAIAALAFGTESVKKVYKIVGPG 198

Query: 211 NAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVIL 270
           N +V  AK  VS  +    ID   GP+E+++IAD  A  ++VA D+ +QAEHGPD+ ++L
Sbjct: 199 NVYVQAAKYLVSSVV---GIDGIEGPTELVIIADETAKAEYVALDMKAQAEHGPDTYIVL 255

Query: 271 LTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQCVEISNQYGPEHLII 330
           L+   ++ RRV E +             +       +I TK+L + +EI+N+  PEHL +
Sbjct: 256 LSNDDELIRRVEEKI-------------KNDKKIYYIIKTKNLDEAIEIANKIAPEHLSL 302

Query: 331 QTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQK-- 388
             ++A  L+D I +AG++ LG+ +P +  DY +G NH+LPT G+      + + DF K  
Sbjct: 303 YVKDAYTLMDKIVNAGAISLGN-TPPAIIDYVAGPNHILPTNGWAKIRGGITVYDFIKPT 361

Query: 389 -RMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
               V++++K+   A  S    LA  E    H  ++  R
Sbjct: 362 MYANVRDINKQLLEASIS----LANYEGFIIHGKSIGAR 396


>UniRef50_D2R570 Histidinol dehydrogenase n=1 Tax=Pirellula staleyi DSM 6068
           RepID=D2R570_9PLAN
          Length = 454

 Score =  243 bits (621), Expect = 8e-63,   Method: Compositional matrix adjust.
 Identities = 161/408 (39%), Positives = 229/408 (56%), Gaps = 20/408 (4%)

Query: 31  SITRTVNDILDNVKARGDEALREYSAKFDKTTVT--ALKVSAEEIAAASERLSDELKQAM 88
           S T  V  I  +V+ RG  A+ +YS K D+  +T   ++VS  E+ AA          A+
Sbjct: 55  SPTEVVETICRDVRERGIAAVLDYSKKLDRADLTPETIRVSQAELDAAHAAADPAFLAAI 114

Query: 89  AVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATP 148
           A   +NI  F TA     V+V    GV  +Q  +P+  +G+ +PGG+A   STVLM A P
Sbjct: 115 ARIQQNILEFQTAILHKEVEVRRN-GVVLRQRYQPLERIGICVPGGAAAYPSTVLMTAVP 173

Query: 149 ASIAGCKKVVLCSPP----PIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVD 204
           A  AG  ++V+ +PP        ++L   +  GV +V+ +GGAQ +AALA+G E +PKVD
Sbjct: 174 AQAAGVSQIVVIAPPTDFGANNRDVLATCKAIGVTEVYRMGGAQGVAALAYGVEGIPKVD 233

Query: 205 KIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGP 264
           KI GPGN FV  AKR V   +D   ID  AGPSEV+VI+D     DF A+DLL+QAEH P
Sbjct: 234 KIVGPGNLFVALAKRHVYGEVD---IDSIAGPSEVVVISDETTRADFTAADLLAQAEHAP 290

Query: 265 DSQVILLTPAADMARRVAEAVERQLAEL----PRAETARQAL-NASRLIVTKDLAQCVEI 319
            + +++       +R   EA +R+L  L     R+E   Q+L +   LI+     +   +
Sbjct: 291 GASILI-----TWSRTALEATKRELERLVQTISRSELTLQSLRDFGCLILVDSPEEACRV 345

Query: 320 SNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCS 379
           +++  PEHL I T NA  L+  I +AG+ FLG++SP + GDYA+G +HVLPT G     S
Sbjct: 346 TSEIAPEHLHIATENAGALLAKIRNAGATFLGNYSPVALGDYAAGPSHVLPTGGTARWAS 405

Query: 380 SLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRV 427
            L    F +  +V + S E    +A  I+ LA  E LTAH+ +V LRV
Sbjct: 406 GLSANHFLRSSSVIDYSAEALRDIAPAIQMLADKEGLTAHRLSVDLRV 453


>UniRef50_Q4JW59 Histidinol dehydrogenase n=104 Tax=Actinobacteria (class)
           RepID=HISX_CORJK
          Length = 450

 Score =  242 bits (618), Expect = 2e-62,   Method: Compositional matrix adjust.
 Identities = 154/408 (37%), Positives = 226/408 (55%), Gaps = 14/408 (3%)

Query: 30  ESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAMA 89
           +S+  TV  I+D V+  G  A  E   +FD  T  +++V AE I AA   L+D++  A+ 
Sbjct: 35  DSVIPTVAPIVDQVREGGARAALEIGQRFDGVTPDSVRVPAEVIDAAVGTLADDVIAALE 94

Query: 90  VAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPA 149
            A+K +  FH+A +     VE  PG    +   PV  VGLY PGG+A   S+V+M   PA
Sbjct: 95  EAIKRVRAFHSAIRPEDKQVEVAPGGIVTERFIPVQRVGLYAPGGNAVYPSSVIMNVVPA 154

Query: 150 SIAGCKKVVLCSPPPIAD----EILYAAQLCGVQDVFNVGGAQAIAALAFGT-----ESV 200
             AG + +V+ SPP         +L A +L GV +V+ VGGAQA+A LA G+     E +
Sbjct: 155 QEAGVESLVVASPPQEGGWPHPTVLAACKLLGVDEVWAVGGAQAVALLAHGSTAEGGEEL 214

Query: 201 PKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQA 260
             VD + GPGN FVT AKR     +    ID  AGP+E+ V+AD  A    +A DL+SQA
Sbjct: 215 EPVDMVTGPGNIFVTAAKRLCRSVV---GIDSEAGPTEIAVLADESANAVEIAYDLISQA 271

Query: 261 EHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNA--SRLIVTKDLAQCVE 318
           EH   +  +L+T +  +A  V   +  +      +E   +AL+   S +++  D+A  + 
Sbjct: 272 EHDTMAASVLITDSEKLADEVVAEMNERYHITENSERVAEALSGQQSGVVLVDDIAAGIR 331

Query: 319 ISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATC 378
            +N YG EHL I T +A  +   IT+AG++F+G +SP   GDYA+G+NHVLPT G     
Sbjct: 332 AANAYGAEHLEIHTEDAHGVAAQITNAGAIFIGRFSPVPLGDYAAGSNHVLPTSGTARHS 391

Query: 379 SSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
           S L    F K + V + ++EG   +A T+ TL+ +E L AH  A++ R
Sbjct: 392 SGLSTLTFLKSVHVIDYNEEGLRGVADTVITLSKSEGLPAHGEAISAR 439


>UniRef50_A0R401 Histidinol dehydrogenase n=2 Tax=Actinomycetales RepID=A0R401_MYCS2
          Length = 451

 Score =  239 bits (611), Expect = 1e-61,   Method: Compositional matrix adjust.
 Identities = 155/423 (36%), Positives = 233/423 (55%), Gaps = 17/423 (4%)

Query: 21  LMRPAISASES-----ITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAA 75
           L +PA+    +     +   V+ +L +++ RG +A+R Y+ + D  +   L++ A+E+  
Sbjct: 17  LKKPAVDGPPAQRDPKVVERVSQMLLDIERRGLDAVRAYARELDGWS-GPLEIGADELRK 75

Query: 76  ASERLSDELKQAMAVAVKNIETFHTAQK--LPPVDVETQPGVRCQQVTRPVASVGLYIPG 133
           + + L  +L++A+ +  +    F  AQ+  L   ++E  PGV       PV  VG Y+P 
Sbjct: 76  SGDALPADLREALELGYERTNRFAVAQRARLTDFEIELAPGVTGGVQYVPVNRVGAYLPA 135

Query: 134 GSAPLFSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQDVFNVGGAQA 189
           G  PL ++  M    A  AG   V+ C+PP         +LY A L     VF VGG QA
Sbjct: 136 GRFPLLASAFMTVGVAKAAGVPTVLACTPPSGEHGAHPAVLYGAYLSRADSVFAVGGVQA 195

Query: 190 IAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATP 249
           + A+AFG      VD + G GNAFVTEAKRQ+  R+    ID+ AGPSEV V+AD  A P
Sbjct: 196 LGAMAFGLIGDGPVDMLVGAGNAFVTEAKRQLFGRV---GIDLLAGPSEVAVLADETADP 252

Query: 250 DFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLI 308
           ++VA+DLL QAEHGP+S   L+T +  + RRV EA++RQL  L   E A  A  +   ++
Sbjct: 253 EWVAADLLGQAEHGPNSPAALITTSETLGRRVIEAIDRQLETLATREVAGPAWRDFGSVL 312

Query: 309 VTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYA-SGTNH 367
           V  D  Q   I++  GPEHL +QT +    +  + + GS+FLG WS  +  D   +GTNH
Sbjct: 313 VASDAEQAAAIADVLGPEHLEVQTADDDYFLKRLRNYGSLFLGRWSTVAYSDKGIAGTNH 372

Query: 368 VLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRV 427
           VLPT       + L ++ F K +T Q  ++E  +ALA  +E ++A E L AH+   T+R+
Sbjct: 373 VLPTGKTARYNAGLSVSRFVKPLTYQRAAREATAALAPAVERISAFEGLAAHEATATIRI 432

Query: 428 NAL 430
             +
Sbjct: 433 EEI 435


>UniRef50_A9G5W4 HisD protein n=1 Tax=Sorangium cellulosum 'So ce 56'
           RepID=A9G5W4_SORC5
          Length = 460

 Score =  239 bits (610), Expect = 2e-61,   Method: Compositional matrix adjust.
 Identities = 165/422 (39%), Positives = 226/422 (53%), Gaps = 30/422 (7%)

Query: 31  SITRTVNDILDNVKARGDEALREYSAKFDKTTVTAL-KVSAEEI------AAASERLSDE 83
           ++T  V +I+DNV+  G  A+  Y  KF++ T  AL + +  E       A A  RLS E
Sbjct: 29  NVTPAVTEIIDNVRRGGTSAVLGYIEKFERRTSKALVRHAGPEAEGGFGGAEALARLSPE 88

Query: 84  LKQAMAVAVKNIETFHTAQK----LPPVDVET------------QPGVRCQQVTRPVASV 127
           ++ A+  A   I  +H  Q+    L P +V              + GV      RP+  V
Sbjct: 89  VRAALETAAARIARYHERQRDAGDLGPANVTANGPALQAGFSYEEEGVLLGMRVRPLRRV 148

Query: 128 GLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVFNVGGA 187
           G+Y PGG A   S+VLM A PA IAG +++VL SP    D  L AA L GV  + + GGA
Sbjct: 149 GVYAPGGKARYPSSVLMSAIPARIAGVREIVLASPS-ADDATLAAAHLSGVTTLLDSGGA 207

Query: 188 QAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGA 247
           QAIAA+A+G   +  VDKI GPGNA+V  AK+ V       +ID   GPSE+L +AD  A
Sbjct: 208 QAIAAMAYGLPELAPVDKIVGPGNAYVACAKKLV---FGDVSIDGITGPSEILALADESA 264

Query: 248 TPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL--NAS 305
            P  VA+DLLSQAEH   S  +L T +A +A  VA  ++  L EL R    + +L  +A+
Sbjct: 265 DPRLVAADLLSQAEHDEASYALLATTSAKLAEAVARELDAALPELTRRAIVQASLSTHAA 324

Query: 306 RLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGT 365
            L+V    A+  EI++Q   EH+     +A  L   I + G+  LGD +P +AGDY +G 
Sbjct: 325 ALVVGSR-ARLAEIADQLAVEHVAFHVADAEGLFSEIGTLGAALLGDLTPVAAGDYLAGP 383

Query: 366 NHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTL 425
           +HVLPT G     + LG+ DF  R ++   S     A    IE LA AE L AH  AV+L
Sbjct: 384 SHVLPTGGSARFGAPLGVYDFVTRASLIRYSSAALRAQGPIIEKLALAEGLQAHARAVSL 443

Query: 426 RV 427
           R+
Sbjct: 444 RL 445


>UniRef50_C0G418 Histidinol dehydrogenase n=2 Tax=Rhizobiales RepID=C0G418_9RHIZ
          Length = 444

 Score =  238 bits (607), Expect = 3e-61,   Method: Compositional matrix adjust.
 Identities = 159/400 (39%), Positives = 221/400 (55%), Gaps = 16/400 (4%)

Query: 15  EQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV--TALKVSAEE 72
           EQ+    +      SE + R V +I+D V+  GD AL +YS +FD+  +  T + V+  E
Sbjct: 13  EQKFAAFLSGKREVSEDVDRAVREIVDRVRREGDSALLDYSRRFDRIDLEKTGIAVTEAE 72

Query: 73  IAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQP-GVRCQQVTRPVASVGLYI 131
           I AA +       +A+ +A   IE  H A++LP  D  T   GV        + +VGLY+
Sbjct: 73  IDAAFDAAPASTVEALKLARDRIEKHH-ARQLPKDDRYTDALGVELGSRWTAIEAVGLYV 131

Query: 132 PGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADE---ILYAAQLCGVQDVFNVGGAQ 188
           PGG+A   S+VLM A PA +AG  ++V+  P P  +    +L AA+L GV +++ VGGAQ
Sbjct: 132 PGGTASYPSSVLMNAMPAKVAGVDRIVMVVPAPDGNLNPLVLVAARLAGVSEIYRVGGAQ 191

Query: 189 AIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGAT 248
           AIAALA+GTE++  V KI GPGNA+V  AKR V        IDM AGPSEVL++AD    
Sbjct: 192 AIAALAYGTETIRPVAKIVGPGNAYVAAAKRIV---FGTVGIDMIAGPSEVLIVADKDNN 248

Query: 249 PDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRL 307
           PD++A+DLL+QAEH   +Q IL+T     A  V EAVERQL  L R ETA  +  +   +
Sbjct: 249 PDWIAADLLAQAEHDTAAQSILMTNDEAFAHAVEEAVERQLHTLARTETASASWRDFGAV 308

Query: 308 IVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNH 367
           I+ KD    + ++N+   EHL I   +A   V  I +AGS+F+G ++P S      G   
Sbjct: 309 ILVKDFEDAIPLANRIAAEHLEIAVADAEAFVPRIRNAGSIFIGGYTPGSDRRLCGGLQ- 367

Query: 368 VLPTYGYTATCSSLGLADFQKRMTVQEL-SKEGFSALAST 406
             P     A C  L L  F  R+    L S+ G  A + T
Sbjct: 368 --PCAANGALCPFL-LRPFGARLYEAHLASQAGLRAASRT 404


>UniRef50_C7LZ86 Histidinol dehydrogenase n=1 Tax=Acidimicrobium ferrooxidans DSM
           10331 RepID=C7LZ86_ACIFD
          Length = 432

 Score =  238 bits (606), Expect = 4e-61,   Method: Compositional matrix adjust.
 Identities = 161/438 (36%), Positives = 230/438 (52%), Gaps = 17/438 (3%)

Query: 1   MSFNTIIDWNSCTAEQQRQLLMRPAISAS-ESITRTVNDILDNVKARGDEALREYSAKFD 59
           M+  T++D    T   +R  L  P ++   E     V +I+ +V+  GD AL + + +FD
Sbjct: 1   MASLTLVDLRETTGALRRDDL--PGVALPVEGPRALVREIVQSVRTGGDGALADLTERFD 58

Query: 60  KTTVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQ 119
                AL +  E +AAA ERL   L +A+ VA   +   + A++ P        G+  ++
Sbjct: 59  GVRPRALVLGREAMAAAYERLDRRLAEALRVARDRVREAYEAER-PAASSLVADGIEVRR 117

Query: 120 VTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQL 175
              PV   G Y+PGG A   S+V+  AT A +AG + VV+ +PP     + D  L A  L
Sbjct: 118 RIVPVERAGCYVPGGQARYPSSVVHTATVARVAGVRDVVVATPPLPDGGLDDATLAACHL 177

Query: 176 CGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMP-- 233
            GV  V   GGAQA+AALA+GTES+ +VD I GPGN FV+ AK++V+     A + +P  
Sbjct: 178 AGVDTVLLAGGAQAVAALAYGTESLERVDVIVGPGNLFVSLAKQEVA-----ADVGVPGA 232

Query: 234 -AGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAEL 292
            AGPSEV+V+AD    P   A D+  QAEHGP     L+T  A  A +V E +   +   
Sbjct: 233 FAGPSEVVVVADGSLEPRVAAIDVAVQAEHGPHGLAWLVTWDARWAEQVLEELAAYVEAS 292

Query: 293 PRAETARQALNA-SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLG 351
           PR       L A   L + +D  Q   +++   PEHL +    A    D +  AG VF+G
Sbjct: 293 PRRAQLESTLEAHGYLALVRDRDQARLVADAIAPEHLELLYDQAVRDADRVRHAGVVFVG 352

Query: 352 DWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLA 411
             +  + GDY +G +HVLPT G     S LGL DFQ+R+ V E+  E  S L   +E LA
Sbjct: 353 RAASAAFGDYVAGPSHVLPTAGTARFASVLGLEDFQRRLHVVEVHDEALSRLGWAVEALA 412

Query: 412 AAERLTAHKNAVTLRVNA 429
            AE L AH +++ +R  A
Sbjct: 413 DAEGLVAHADSIRIRREA 430


>UniRef50_A4QA32 Histidinol dehydrogenase n=16 Tax=cellular organisms
           RepID=A4QA32_CORGB
          Length = 408

 Score =  236 bits (603), Expect = 1e-60,   Method: Compositional matrix adjust.
 Identities = 138/395 (34%), Positives = 215/395 (54%), Gaps = 10/395 (2%)

Query: 39  ILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETF 98
           ++ +++ARGDEA+REYS KFD     +  V  E++    +R+ +++ + +      +   
Sbjct: 1   MIADIRARGDEAVREYSLKFDNYGPDSFLVQGEQLQEILDRVPEQVIEDIKFVQDQVRKV 60

Query: 99  HTAQ--KLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKK 156
             AQ   +   ++ET PGV   Q   P+ S G Y+PGG  PL ++  M    A +AG K+
Sbjct: 61  AQAQLQSMGEFEIETLPGVHIGQKNVPIDSAGAYVPGGKYPLLASAHMTILTAKVAGVKR 120

Query: 157 VVLCSP---PPIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAF 213
           VV C+P     + D  + A  L G  +++ +GG QAIAA+A GTE++  V  I GPGNAF
Sbjct: 121 VVACTPLIQGEVPDATVAAMHLAGADEIYLLGGIQAIAAMAIGTETIKPVSIIAGPGNAF 180

Query: 214 VTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTP 273
           V EAKRQ+   +    ID+ AGP+E L++AD    P   A DLLSQAEHGPDS  +L++ 
Sbjct: 181 VAEAKRQLFGEV---GIDLLAGPTETLIVADETTDPFIAAVDLLSQAEHGPDSPAVLIST 237

Query: 274 AADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQT 332
              +A +V + +   L E+P  + A  A  +   + V + +     +++++  EH+ I T
Sbjct: 238 DRAVAEQVIDHINELLPEMPTKDYAEVAWRDWGEVHVVESIEDAFSLADKFASEHVQILT 297

Query: 333 RNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTV 392
            + R  +D +   G++FLG+ +  S GD   GTNHVLPT G       L +  + + +T 
Sbjct: 298 ASPRRALDEMKHYGALFLGEGTCVSYGDKVIGTNHVLPTRGAARYTGGLWVGKYVRTITY 357

Query: 393 QELSKEGFSALASTIETLAA-AERLTAHKNAVTLR 426
           QE++ E  SA    +   AA  ER   H  +  +R
Sbjct: 358 QEVTNEDSSAFFGELCGRAARVERFEGHARSGDVR 392


>UniRef50_Q5YYQ0 Histidinol dehydrogenase n=8 Tax=Actinomycetales RepID=HISX_NOCFA
          Length = 445

 Score =  236 bits (602), Expect = 1e-60,   Method: Compositional matrix adjust.
 Identities = 158/415 (38%), Positives = 229/415 (55%), Gaps = 16/415 (3%)

Query: 30  ESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAMA 89
           +S+   V  +++ V+ RG  A  E+  KFD      ++V A E+A A + L   ++ A+ 
Sbjct: 34  DSVLHHVRPVVEAVRERGAAAALEFGEKFDGVVPATVRVPAAELARALDELDPAVRAALE 93

Query: 90  VAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPA 149
            ++      H  Q+      E  PG    +   PVA VGLY+PGG+A   S+V+M   PA
Sbjct: 94  ESIARARRVHADQRRTDTTTEVVPGGTVTERWVPVARVGLYVPGGNAVYPSSVVMNVVPA 153

Query: 150 SIAGCKKVVLCSPPPI------ADEILYAAQLCGVQDVFNVGGAQAIAALAFG---TESV 200
             AG   +V+ SPP           IL AA L GV++V+ VGGAQA+A L++G   T+  
Sbjct: 154 QTAGVGSLVVASPPQANFGGLPHPTILAAAALLGVEEVWAVGGAQAVALLSYGGTDTDGA 213

Query: 201 P--KVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLS 258
           P   VD I GPGN +VT AKR + + L G  ID  AGP+E+ ++AD+ A P  VA+DL+S
Sbjct: 214 PLDPVDLITGPGNIYVTAAKR-LCRGLVG--IDAEAGPTEIAILADATADPAHVAADLIS 270

Query: 259 QAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNA--SRLIVTKDLAQC 316
           QAEH   +  +L+T +  +A  V  A+  QLA +  AE  R AL    S  ++  D+ Q 
Sbjct: 271 QAEHDVLAASVLVTDSVALADAVDAALTAQLAVVKHAERVRTALTGKQSGTVLVDDITQG 330

Query: 317 VEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTA 376
           + + + Y  EHL IQT +A  +   + SAG+VF+G ++P S GDY +G+NHVLPT G   
Sbjct: 331 LRVVDAYAAEHLEIQTADASAVAARVRSAGAVFVGPYAPVSLGDYCAGSNHVLPTAGCAR 390

Query: 377 TCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNALK 431
             S L +  F + + V E ++     +A  +  LA AE L AH  AVT+R  AL 
Sbjct: 391 HSSGLSVQTFLRGIHVVEYTEAALKDVAGHVVALADAEDLPAHGQAVTVRFEALS 445


>UniRef50_Q82AA6 Histidinol dehydrogenase n=29 Tax=Actinobacteridae RepID=HISX_STRAW
          Length = 441

 Score =  231 bits (588), Expect = 6e-59,   Method: Compositional matrix adjust.
 Identities = 150/422 (35%), Positives = 229/422 (54%), Gaps = 21/422 (4%)

Query: 18  RQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAAS 77
           R LL R     S ++ + V  I + V  RGD AL +++ KFD   + +++V A  +A A 
Sbjct: 19  RDLLPRADFDVSAALEK-VRPICEAVHHRGDAALIDFAEKFDGVRLESVRVPARALADAL 77

Query: 78  ERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAP 137
           E+L   ++ A+  +++     H  Q+      +  PG    +   PV  VGLY PGG + 
Sbjct: 78  EQLDPAVRAALEESIRRARLVHREQRRTTHTTQVVPGGSVTEKWVPVDRVGLYAPGGRSV 137

Query: 138 LFSTVLMLATPASIAGCKKVVLCSPPPI------ADEILYAAQLCGVQDVFNVGGAQAIA 191
             S+V+M   PA  AG + + L SP            IL A  L GV +V+  GGA A+A
Sbjct: 138 YPSSVVMNVVPAQEAGVESIALASPAQAEFGGLPHPTILAACALLGVDEVYAAGGATAVA 197

Query: 192 ALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDF 251
             A+GTES    D + GPGN +V  AKR  + ++    ID  AGP+E+ V+ADS A P  
Sbjct: 198 MFAYGTESCAPADMVTGPGNIWVAAAKRYFTGKI---GIDAEAGPTEIAVLADSTADPVH 254

Query: 252 VASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLA-------ELPRAETARQALNA 304
           VASDL+SQAEH P +  +L+T + ++A  V + +E Q+A        +  A   RQ    
Sbjct: 255 VASDLISQAEHDPLAAAVLVTDSVELADAVEKELEPQVAATKHIDDRIVPALKGRQ---- 310

Query: 305 SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASG 364
           S +++   + + + + + YG EHL IQT +A  + D + +AG++F+G W+P S GDYA+G
Sbjct: 311 SAIVLVDGVDEGLRVVDAYGAEHLEIQTADAAAVADRVRNAGAIFIGPWAPVSLGDYAAG 370

Query: 365 TNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVT 424
           +NHVLPT G     S L +  F + + + + +K+  + +A  + TLA AE L AH  A+ 
Sbjct: 371 SNHVLPTGGCACHSSGLSVQSFLRGIHIVDYTKDALADVAHHVVTLAEAEDLPAHGAAIK 430

Query: 425 LR 426
            R
Sbjct: 431 AR 432


>UniRef50_A3Q131 Histidinol dehydrogenase n=6 Tax=Mycobacterium RepID=A3Q131_MYCSJ
          Length = 474

 Score =  230 bits (586), Expect = 8e-59,   Method: Compositional matrix adjust.
 Identities = 161/456 (35%), Positives = 227/456 (49%), Gaps = 51/456 (11%)

Query: 16  QQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAA 75
           Q R  L R  +   +++   V  I++ V  RG EA  EY   FD     +++V AE +A+
Sbjct: 22  QLRSALPRGGVDV-DAVVPKVRPIVEAVAERGAEAALEYGEAFDGVRPASVRVPAERLAS 80

Query: 76  ASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGS 135
           A   L  +++ A+ VA+      H  Q+         PG    +   P+  VGLY+PGG+
Sbjct: 81  ALAELDPDVRAALQVAIDRARAVHADQRRTDTTTTLAPGATVTERWVPLERVGLYVPGGN 140

Query: 136 APLFSTVLMLATPASIAGCKKVVLCSPPPIADE-------ILYAAQLCGVQDVFNVGGAQ 188
           A   S+V+M   PA  AG   +V+ SPP  AD        IL AA L GV +V+ VGGAQ
Sbjct: 141 AVYPSSVVMNVVPAQTAGVDSLVIASPPQ-ADHGGLPHPTILAAAALLGVDEVWAVGGAQ 199

Query: 189 AIAALAFG------------------------------------TESVPKVDKIFGPGNA 212
           A+A LA+G                                    TE  P VD I GPGN 
Sbjct: 200 AVALLAYGGTDIDGTGASGAPGDGTGASGAPGDGTGASGAPGDVTELAP-VDMITGPGNI 258

Query: 213 FVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLT 272
           +VT AKR    ++    ID  AGP+E+ V+AD  A P  VA+DL+SQAEH   +  +L+T
Sbjct: 259 YVTAAKRICRSQV---GIDAEAGPTEIAVLADHTADPVHVAADLISQAEHDEMAASVLVT 315

Query: 273 PAADMARRVAEAVERQLAELPRAETARQALNA--SRLIVTKDLAQCVEISNQYGPEHLII 330
            + D+A  +   + RQL      E    AL    S +++  DL   V + N Y  EHL I
Sbjct: 316 TSPDLADAIDRELRRQLETTVHRERVSTALTGEQSAIVLVDDLDAGVRVVNAYAAEHLEI 375

Query: 331 QTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRM 390
           QT +A E+   I SAG++F+G ++P S GDY +G+NHVLPT G     S L +  F + +
Sbjct: 376 QTVDAAEVAGRIRSAGAIFVGPYAPVSLGDYCAGSNHVLPTAGCARHSSGLSVQTFLRGI 435

Query: 391 TVQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
            V + ++     ++  + TLA AE L AH  AV  R
Sbjct: 436 HVVDYTEAALKDVSGYVITLAQAENLPAHGEAVRRR 471


>UniRef50_Q13I58 Histidinol dehydrogenase n=22 Tax=cellular organisms
           RepID=Q13I58_BURXL
          Length = 443

 Score =  224 bits (570), Expect = 7e-57,   Method: Compositional matrix adjust.
 Identities = 141/399 (35%), Positives = 206/399 (51%), Gaps = 10/399 (2%)

Query: 36  VNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAMAVAVKNI 95
           V  I+ +++ +GDEA+REYS KFD       ++S  EI  A ++LS    + +A A   +
Sbjct: 29  VESIIQHIEEKGDEAVREYSRKFDNWDPGDFRLSRPEIETARKQLSAREIEDIAFAQTQV 88

Query: 96  ETFHTAQKLPPVDVETQ--PGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAG 153
             F   Q+    DVET+  PGV       P+ +VG YIPGG  PL ++  M    A +AG
Sbjct: 89  RNFARIQRDSMRDVETETLPGVVLGHKHIPMNAVGCYIPGGKYPLLASAHMSVLTAKVAG 148

Query: 154 CKKVVLCSPPPIAD---EILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPG 210
             +VV  +PP        I+ A  + G  ++  +GG QA+ A+A GT +V  VD + GPG
Sbjct: 149 VARVVSTAPPYQGKPHPAIVTAMDMAGADEILVLGGIQAVVAMAVGTPTVAPVDMLVGPG 208

Query: 211 NAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVIL 270
           N FV EAKRQ+  R+    ID+ AGP+E LVIAD     +  A DLL QAEHG  S  IL
Sbjct: 209 NMFVAEAKRQLYGRV---GIDLFAGPTETLVIADESVDGELCAVDLLGQAEHGATSPSIL 265

Query: 271 LTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVEISNQYGPEHLI 329
           LT +  +AR     +ERQL  LP A  A Q+  +   +IV     + +++++    EH+ 
Sbjct: 266 LTNSEKLARDTLAEIERQLKILPTASIAAQSWADCGEVIVCDTYEEMLQVADDIASEHVQ 325

Query: 330 IQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKR 389
           + T +    ++++T+ G++FLG  +  S GD   GTNH LPT         L +  F K 
Sbjct: 326 VMTEDPDFFLNNMTNYGALFLGPRTNVSFGDKVIGTNHTLPTNRSARYTGGLWVGKFLKT 385

Query: 390 MTVQEL-SKEGFSALASTIETLAAAERLTAHKNAVTLRV 427
            T Q + + E  + +      L   E    H     +RV
Sbjct: 386 CTYQRVTTNEASAIIGEYCSRLCHMENFAGHGEQANIRV 424


>UniRef50_B1ZNB2 Histidinol dehydrogenase n=3 Tax=Verrucomicrobia RepID=B1ZNB2_OPITP
          Length = 431

 Score =  220 bits (561), Expect = 8e-56,   Method: Compositional matrix adjust.
 Identities = 154/408 (37%), Positives = 229/408 (56%), Gaps = 19/408 (4%)

Query: 32  ITRTVNDILDNVKARGDEALREYSAKFDKTTVTA--LKVSAEEIAAASERLSDELKQAMA 89
           IT +V  IL +V+ RGDEA+  Y+AKFD   + A  L+V   ++  A++RL    ++A+ 
Sbjct: 28  ITESVAAILADVRERGDEAVVYYAAKFDGAKLRARDLRVKPSDLTVAAKRLPAAERRALV 87

Query: 90  VAVKNIETFHTAQKLPPVDVETQP-GVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATP 148
            A  +I  ++  + LP       P G    +   P+  VGLY+PGG  PL STVLM  T 
Sbjct: 88  AARDSIMDYNR-RGLPRGWTAKNPHGAMVGEKFDPLRRVGLYVPGGQVPLVSTVLMTVTL 146

Query: 149 ASIAGCKKVVLCSP----PPIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVD 204
           A IA C +VV+ +P      IAD +L A  L GV +V+ VGG QAI A+AFGT ++P VD
Sbjct: 147 AKIAQCPQVVVFTPCNAEGKIADGLLAALHLLGVDEVYRVGGVQAIGAMAFGTTTIPPVD 206

Query: 205 KIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGP 264
           KIFGPGNA+  EA RQV        ++   GPSE++VIAD  A  D+ A+DLL+QAEHG 
Sbjct: 207 KIFGPGNAYTCEAMRQV---FGIVGVNGLPGPSELMVIADDTARADYAAADLLAQAEHGS 263

Query: 265 DSQVILLTPAADMARRVAEAVER---QLAELPRAETARQALNASRL-IVTKDLAQCVEIS 320
             + + L   A  +R + E V     QL  L R+E  ++ L    L I    + Q   ++
Sbjct: 264 GREKVYLV--ATSSRVITEIVNEMNGQLQTLTRSEKTQRVLEQGFLAIEVGSMQQAAAVA 321

Query: 321 NQYGPEH--LIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATC 378
           N   PEH  L++     ++L  ++T+AG++ +G+ +P + GD+ +G +HVLPT       
Sbjct: 322 NYVAPEHLELLVSEAAVKQLTKAVTTAGAIMIGNETPTALGDFTAGPSHVLPTGRAGRFF 381

Query: 379 SSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
           S + ++DF +R ++    ++     A  +   AA ERL AH  +V +R
Sbjct: 382 SGMRVSDFLRRTSLVRYDRKSVRKGAPVVAAFAAMERLDAHGRSVKIR 429


>UniRef50_C1A4M1 Histidinol dehydrogenase n=1 Tax=Gemmatimonas aurantiaca T-27
           RepID=C1A4M1_GEMAT
          Length = 816

 Score =  220 bits (560), Expect = 1e-55,   Method: Compositional matrix adjust.
 Identities = 159/425 (37%), Positives = 242/425 (56%), Gaps = 21/425 (4%)

Query: 9   WNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKV 68
           W+      +R L  R A +   +I    + ++D V+  GD AL + + +FD  T+  L+V
Sbjct: 13  WDRLDNATRRALEDR-ASTVDPTIRERTSAVIDAVRRTGDAALIDMARRFDGATLETLEV 71

Query: 69  SAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVET-QPGVRCQQVTRPVASV 127
              E   A   L   L+Q++  A +NI T H A  LP +   T +PG+   +   P+  V
Sbjct: 72  PRAEWDRALAALDPALRQSLERAARNIATVHRA-FLPTITRSTPEPGITVVRRPDPLGRV 130

Query: 128 GLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP-----PIADEILYAAQLCGVQDVF 182
           G+Y PGG A   S++LM A PA +AG  ++++C+PP     P    +  AA     + VF
Sbjct: 131 GIYAPGGRAAYPSSLLMGAVPARVAGVGEIIVCTPPGPDGRPADVVLAAAALANVDR-VF 189

Query: 183 NVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVI 242
            VGGA AIAA+A GT SVP+VD+I GPGNA+V EAK Q+   +   AID PAGPSE+LV+
Sbjct: 190 AVGGAGAIAAMALGTASVPRVDRIMGPGNAYVAEAKLQL---VSAVAIDAPAGPSELLVL 246

Query: 243 ADSGATPDFVASDLLSQAEHGPDSQVILL----TPAADMARRVAEAVERQLAELPRAETA 298
           AD+ A  + +A ++L+QAEH PD+ V+ +    +  + +A RV  A++ QLA  PRA+  
Sbjct: 247 ADASADANTIAREMLAQAEHDPDAAVLAVIVDHSATSSLATRVETALQTQLASAPRADVM 306

Query: 299 RQALNASRLIV-TKDLAQCVEISNQYGPEHLII---QTRNARELVDSITSAGSVFLGDWS 354
           R AL A   +V    + + +  +N++  EHL++    T+  R L  ++ +AG++F+G  S
Sbjct: 307 RAALGARGGVVHMTSMDEAITFANRWAAEHLLLLVDDTQRDRVLA-ALRNAGTIFVGASS 365

Query: 355 PESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAE 414
             + GDY +G NHVLPT G   + S L   DF +  T QE++    ++L++ +   A AE
Sbjct: 366 SVAFGDYMTGANHVLPTAGAARSYSGLSTLDFVRWTTWQEVTPAAAASLSADVGRFADAE 425

Query: 415 RLTAH 419
            L AH
Sbjct: 426 GLPAH 430


>UniRef50_Q46N53 Histidinol dehydrogenase 2 n=50 Tax=root RepID=HISX2_RALEJ
          Length = 436

 Score =  215 bits (548), Expect = 2e-54,   Method: Compositional matrix adjust.
 Identities = 139/397 (35%), Positives = 210/397 (52%), Gaps = 17/397 (4%)

Query: 34  RTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAMAVAVK 93
           + V ++L  ++ARG +A+R+Y+ + D  +   + ++ ++I   ++ +   ++  +  A++
Sbjct: 21  KVVTEMLAEIQARGKDAVRQYAKQLDGWS-GDIVLTPDQIREQTKDVPAGVRADIDFAIR 79

Query: 94  NIETFHTAQK--LPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASI 151
            +  F  AQ+  L    VE  PGV   Q   PV  VG Y P G     ++  M    A  
Sbjct: 80  QVTDFALAQRESLKEFSVELHPGVTAGQRVLPVNVVGCYAPAGRYAHIASAYMGVATAKA 139

Query: 152 AGCKKVVLCSPP----PIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIF 207
           AG K VV CS P     I   +LYA Q  G   +  +GG QAIA++A+G  +    D + 
Sbjct: 140 AGVKTVVACSSPFRGQGIHPHVLYAFQAAGADVIMALGGVQAIASMAYGLFTGKPADVVV 199

Query: 208 GPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQ 267
           GPGN FV EAKR +  ++    ID+ AGPSEV VIAD  A P  VASDL+ QAEHG +S 
Sbjct: 200 GPGNKFVAEAKRSLYGQV---GIDVFAGPSEVAVIADETADPAIVASDLVGQAEHGHESP 256

Query: 268 VILLTPAADMARRVAEAVERQLAELPRAETARQALNAS-----RLIVTKDLAQCVEISNQ 322
             L T + D+A RV   V   +A+LP   TAR A  A+      +I+     + VEIS++
Sbjct: 257 AWLFTTSRDLADRVMALVPELIAKLP--PTARDAATAAWRDYGEVILCGTREEVVEISDR 314

Query: 323 YGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLG 382
           Y  EHL + T +    + ++T  GS+FLG+ +  + GD  SG NHVLPT G       L 
Sbjct: 315 YASEHLEVHTADLDWWLANLTCYGSLFLGEETTVAFGDKTSGPNHVLPTKGAARYSGGLS 374

Query: 383 LADFQKRMTVQELSKEGFSALASTIETLAAAERLTAH 419
           +  F K +T Q++++E    +      ++  E + AH
Sbjct: 375 VHKFMKTLTWQQMTREATRQIGQVTARISRLEGMEAH 411


>UniRef50_C7RAI8 Histidinol dehydrogenase n=1 Tax=Kangiella koreensis DSM 16069
           RepID=C7RAI8_KANKD
          Length = 405

 Score =  214 bits (546), Expect = 4e-54,   Method: Compositional matrix adjust.
 Identities = 138/409 (33%), Positives = 220/409 (53%), Gaps = 24/409 (5%)

Query: 23  RPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSD 82
           RP ++ S  + + V  +L  ++  GD A+   S +FD      +++          +L +
Sbjct: 15  RPNLTQSPELFQQVAKLLKEIETGGDLAIDNLSKRFDGFQPRKIELRPYRDYELEPQLLN 74

Query: 83  ELKQAMAVAVKNIETFHTAQK--LPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFS 140
            ++QA     + IE F   QK  L P  +E   GV   Q + P+ ++G YIPGG  PL S
Sbjct: 75  SIEQA----AQRIEAFCQLQKGSLQPQQIEEASGVFGFQYS-PIEAIGAYIPGGRFPLIS 129

Query: 141 TVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESV 200
           T LM   PA +AGC++ V CSP  +   IL AA L G  + + +GGAQA+AA+A+G +++
Sbjct: 130 TALMTLIPARVAGCQRRVACSPS-VHPAILAAASLAGATEFWQIGGAQAVAAMAYGYQTM 188

Query: 201 PKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQA 260
             V  + GPGN +V  AK+ +  R+    ID+ AGPSE+L++ADS A  +++ +D+ +QA
Sbjct: 189 LPVQMVVGPGNQYVNVAKQLLQSRIK---IDVAAGPSELLILADSNANQEWLIADMAAQA 245

Query: 261 EHGPDSQVILLTPAADMARRVAEAVERQLA---ELPRAETARQALNASRLIVTKDLAQCV 317
           EH P +Q +L++   D+A    +++ +QL    EL       Q +    L+   D    +
Sbjct: 246 EHDPQAQSVLVSD--DIA--FLQSIGQQLTANDELNNLLKGEQIV----LLQANDCEAMI 297

Query: 318 EISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTAT 377
             SN+Y PEHL++   + R    S+   GS+F+G  S  + GDY +G NH LPT G    
Sbjct: 298 RFSNRYAPEHLLL--ADERIASQSLKHYGSLFIGQNSAVAFGDYCAGPNHTLPTMGSANR 355

Query: 378 CSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
            S L +  F    + Q+++ +G   LA     LA AE+L  H+ ++ +R
Sbjct: 356 SSGLCVQSFMNIQSYQQINDQGRIQLAEIGRPLAEAEQLVWHERSMQVR 404


>UniRef50_C0GVA3 Histidinol dehydrogenase n=1 Tax=Desulfonatronospira thiodismutans
           ASO3-1 RepID=C0GVA3_9DELT
          Length = 436

 Score =  209 bits (533), Expect = 1e-52,   Method: Compositional matrix adjust.
 Identities = 134/406 (33%), Positives = 204/406 (50%), Gaps = 10/406 (2%)

Query: 32  ITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAMAVA 91
           I   V  +LD+++ RG+ A+RE +AK+D  + T   +  E+       + +++K  +  A
Sbjct: 18  IREAVTFLLDDIRTRGEPAVREMAAKYDGWS-TDFVLQEEKKERLIAMVPEQVKTDIRFA 76

Query: 92  VKNIETFHTAQK--LPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPA 149
              +  F   Q+  +   +V   PGVR  Q   PV   G Y+PGG      + +M    A
Sbjct: 77  HDQVFNFARMQRQSIQDFEVRPHPGVRLGQRVLPVDVAGCYVPGGRFAHACSAIMSVATA 136

Query: 150 SIAGCKKVVLCSPP---PIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKI 206
             AG   VV CSPP    IA  + +A  L G   +  +GG Q +AA+A+G  +    D +
Sbjct: 137 KAAGVPFVVACSPPREESIAPAVAFAMDLAGADVILELGGVQGVAAMAYGYFTNRPADIL 196

Query: 207 FGPGNAFVTEAKRQVSQRLDG-AAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPD 265
            GPGNA+V EAK  ++   DG   ID+ AGP+E  +IAD  A P  +A DL+SQAEHGPD
Sbjct: 197 VGPGNAYVAEAKALLAG--DGTCGIDVYAGPTESAIIADRSADPMTIAIDLVSQAEHGPD 254

Query: 266 SQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVEISNQYG 324
           S V L T   D+A +V   V R +A++P     + A  +   +I+  +  +   + + Y 
Sbjct: 255 SPVWLFTDCRDLAYQVLNLVPRVIADMPDPHVPKTAWADFGEIILCNNRDEICRVCDTYA 314

Query: 325 PEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLA 384
           PEH+ I   +    ++S+ S GS+FLG+ S  + GD  SGTNH+LPT         L + 
Sbjct: 315 PEHVQILAADPDWWLESLRSYGSLFLGEGSSVAHGDKCSGTNHILPTRKAAQHSGGLSVH 374

Query: 385 DFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNAL 430
            F K  T QE+  E     ++    L+  E +  H  +   R+   
Sbjct: 375 KFLKISTYQEIDTEASKRFSAVASRLSRVEGMEGHARSCDWRLTKF 420


>UniRef50_B7FPZ7 Histidinol dehydrogenase (Fragment) n=3 Tax=Eukaryota
           RepID=B7FPZ7_PHATR
          Length = 347

 Score =  208 bits (530), Expect = 3e-52,   Method: Compositional matrix adjust.
 Identities = 136/335 (40%), Positives = 183/335 (54%), Gaps = 10/335 (2%)

Query: 98  FHTAQKLPPVDVETQ-PGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKK 156
           F T Q+   VD E   PG +  Q  RP  + G Y PGG  PL S+V+M A  A  AGC+ 
Sbjct: 4   FATMQRSSVVDKEMDIPGGKAGQTVRPCGAAGCYAPGGRYPLPSSVIMTAVTARAAGCET 63

Query: 157 VVLCSPPPIADEILYAAQLCGVQDVFNVGGAQAIAALAFGT--ESVPKVDKIFGPGNAFV 214
           VVL SP P A   L AA L G      VGGAQAIA++A+G     VP+ D I GPGN +V
Sbjct: 64  VVLSSPKP-APITLAAAYLSGADHFLCVGGAQAIASMAYGIVDSDVPRCDVICGPGNKWV 122

Query: 215 TEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPA 274
           T AK  V+       IDM AGPSEVLVI D  A P+ VA+DL++QAEH   ++ ILL+ +
Sbjct: 123 TAAKSIVNGH---CGIDMLAGPSEVLVICDDTANPEIVAADLIAQAEHDVVARAILLSTS 179

Query: 275 ADMARRVAEAVERQLAELPRAE--TARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQT 332
             +  +V E V +Q+  LP     TA +AL  S  +  + L QC+ IS+   PEHL IQT
Sbjct: 180 DAIIEQVDENVSKQIEALPEPNRSTALEALKQSFAVKCESLEQCIAISDDIAPEHLEIQT 239

Query: 333 RNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTV 392
           R+A ++ ++  + G +F+G+ + E  GDY +G NH LPT G       L + +F +  T 
Sbjct: 240 RDAMKVGEACNNYGGLFIGEHAAEVLGDYGAGPNHTLPTGGTGRYTGGLSVFNFLRVRTW 299

Query: 393 QELSKEGFS-ALASTIETLAAAERLTAHKNAVTLR 426
             +     S  + +    +A  E L  H  A   R
Sbjct: 300 MRVDNAAASQTMVNDSIIMARLEGLEGHARAAETR 334


>UniRef50_B5YLM0 Histidinol dehydrogenase n=1 Tax=Thalassiosira pseudonana CCMP1335
           RepID=B5YLM0_THAPS
          Length = 441

 Score =  205 bits (521), Expect = 3e-51,   Method: Compositional matrix adjust.
 Identities = 139/379 (36%), Positives = 200/379 (52%), Gaps = 20/379 (5%)

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQ-PGVRCQQVTR 122
           ++  VS+ +   A + LSDE ++++      ++ F  AQ+   VDVE   PG +      
Sbjct: 65  SSYTVSSAQCKEAFDSLSDEDRRSLLNIHARVKLFADAQRGSVVDVEVDIPGGKAGHTVS 124

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVF 182
           P  + G Y PGG  PL S+VLM    A  AGC  VVL SP P A   L AA + G   V 
Sbjct: 125 PCRAAGCYAPGGRYPLPSSVLMTVVTARSAGCPYVVLASPRP-APITLAAAHVAGADVVL 183

Query: 183 NVGGAQAIAALAFGTE------------SVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAI 230
            VGGAQAI  +A+G +            ++P  D I GPGN +VT AK  V+       I
Sbjct: 184 CVGGAQAIGCMAYGVDEYDGEDGGTKVDAIPACDVIVGPGNKWVTAAKSIVNGH---CGI 240

Query: 231 DMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLA 290
           DM AGPSEVLVI D  A  + VA+DL++QAEH   ++ IL++    +  +V + VE+Q+ 
Sbjct: 241 DMLAGPSEVLVICDHTANAEIVAADLIAQAEHDVVARAILVSDDKTVIDKVDQEVEKQVE 300

Query: 291 ELPRAE--TARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSV 348
            LP     TA++AL  S  I+ KD+ +C+ +S++  PEHL IQT N++ +    ++ G +
Sbjct: 301 CLPEPNRSTAKEALKQSFSILCKDIDECIAMSDKLAPEHLEIQTLNSQSVGMKCSNYGGL 360

Query: 349 FLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFS-ALASTI 407
           F+G  + E  GDY +G NH LPT G       L + +F +  T   + +EG S  +    
Sbjct: 361 FIGTHAAEVLGDYGAGPNHTLPTGGTGRYTGGLSVFNFLRIRTWMRIDEEGKSQEMVEDS 420

Query: 408 ETLAAAERLTAHKNAVTLR 426
             +A  E L  H  A   R
Sbjct: 421 VRMARLEGLEGHARAAEKR 439


>UniRef50_B5YE85 Histidinol dehydrogenase n=1 Tax=Dictyoglomus thermophilum H-6-12
           RepID=B5YE85_DICT6
          Length = 416

 Score =  202 bits (514), Expect = 2e-50,   Method: Compositional matrix adjust.
 Identities = 127/409 (31%), Positives = 218/409 (53%), Gaps = 18/409 (4%)

Query: 21  LMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDK--TTVTALKVSAEEIAAASE 78
            +R   S  + I + V  I++ VK +GD AL ++S ++D   +     K++  +I     
Sbjct: 14  FLRIEDSKIKEIEKNVEFIIEEVKTKGDLALYDFSLRYDNYDSRKYGFKINVPDID---- 69

Query: 79  RLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPL 138
            LS +   A+ V ++ ++ ++  +       +    +  Q V  PV SV LY+PGG A  
Sbjct: 70  -LSTDFAVAIKVMIERVKNYYMHEYKNSWFYKDGESIFGQLVV-PVDSVLLYVPGGRASY 127

Query: 139 FSTVLMLATPASIAGCKKVVLCSPPPIADE--ILYAAQLCGVQDVFNVGGAQAIAALAFG 196
            STV+M   PA IAG K + + +PP   D+  +LY  ++ G+++++ +GGA AI+A A+G
Sbjct: 128 PSTVVMGLVPAIIAGVKNLYVTTPPSKRDDKNLLYTLRILGIKELYLLGGAHAISAFAYG 187

Query: 197 TESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDF--VAS 254
           TES+PKVD I GPGN +V  AK++V   ++   ID   GPSEVLV  +     +   V  
Sbjct: 188 TESIPKVDMIIGPGNLYVALAKKKVFGDVN---IDGIFGPSEVLVWVNYDKDLNLRKVVC 244

Query: 255 DLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLA 314
           D L+Q EH P  +  ++  + ++   + E +++++ +  R +  +++L  S LI+ ++  
Sbjct: 245 DFLAQLEHSPYDRGWIIV-SENLVYDLLELIKKEVEDSERGDILKESLKNSFLIIEENEK 303

Query: 315 QCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGY 374
             + + NQ GPEHL I        +  I +AG++F+   S    GD+ +G +H+LPT G 
Sbjct: 304 NAINLINQIGPEHLEIIDPFGERYIPYIKNAGAIFINHSS--IFGDFIAGPSHILPTGGS 361

Query: 375 TATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAV 423
               S L +  F KR++  +LS +    LA    T+A  E    H+ ++
Sbjct: 362 AKFSSGLSVNSFLKRISFVKLSTQDQKILAKYGSTIAREEGFYMHEKSL 410


>UniRef50_B8E2C3 Histidinol dehydrogenase n=1 Tax=Dictyoglomus turgidum DSM 6724
           RepID=B8E2C3_DICTD
          Length = 417

 Score =  201 bits (511), Expect = 5e-50,   Method: Compositional matrix adjust.
 Identities = 128/410 (31%), Positives = 219/410 (53%), Gaps = 19/410 (4%)

Query: 21  LMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDK--TTVTALKVSAEEIAAASE 78
           L+R   S  + + + V+ I++ ++ +GD AL  +S KFD   +     K+S  EI     
Sbjct: 14  LLRMEESKVKEVEKEVDFIVEEIRTKGDLALHNFSLKFDNYDSKKYGFKISVPEID---- 69

Query: 79  RLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPL 138
            LS++   A+ V ++ ++ ++  +       +    +  Q +  PV SV LY+PGG A  
Sbjct: 70  -LSNDFATAIKVMIERVKNYYIHEYKNSWFYKDGESILGQLIV-PVDSVLLYVPGGKASY 127

Query: 139 FSTVLMLATPASIAGCKKVVLCSPPPIADE--ILYAAQLCGVQDVFNVGGAQAIAALAFG 196
            STV+M   PA IAG K + + +PP   ++  +LY  +L G+++++ +GGA AI+A A+G
Sbjct: 128 PSTVVMGLIPAMIAGVKNLYVTTPPSKREDRNLLYTLRLLGIKELYVLGGAHAISAFAYG 187

Query: 197 TESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLV-IADSGATPDF--VA 253
           TES+PKVD I GPGN +V  AK++V   ++   ID   GPSE+LV I   G   +   + 
Sbjct: 188 TESIPKVDMIIGPGNLYVALAKKRVFGDVN---IDGIFGPSEILVWINYRGKDLNLRKIV 244

Query: 254 SDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDL 313
            D L+Q EH P  +  ++ P  ++  +V   ++ ++    R +  ++A+  S LI+ +D 
Sbjct: 245 CDFLAQLEHSPYDRGWMILP-EELLDKVMGLIKEEVEGSGRGDILKEAIKNSFLIIEEDE 303

Query: 314 AQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYG 373
            + + + NQ  PEHL I   +    +  I +AG++F+   S    GD+ +G +H+LPT G
Sbjct: 304 ERAINLINQIAPEHLEIIDFSGERHIPYIKNAGAIFINHSS--IFGDFIAGPSHILPTGG 361

Query: 374 YTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAV 423
                S L +  F KR++  +LS +    LA     +A  E    H+ ++
Sbjct: 362 SAKFSSGLSVNSFLKRISFVKLSAKEQKILAEYGSIIAREEGFYMHEKSL 411


>UniRef50_UPI0001C3165E histidinol dehydrogenase n=1 Tax=Conexibacter woesei DSM 14684
           RepID=UPI0001C3165E
          Length = 426

 Score =  192 bits (488), Expect = 2e-47,   Method: Compositional matrix adjust.
 Identities = 155/416 (37%), Positives = 217/416 (52%), Gaps = 24/416 (5%)

Query: 22  MRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV--TALKVSAEEIAAASER 79
           +R  + A+ SI   V  I+ +V+ RGD A+ E +   D       AL+VS  E+ AA + 
Sbjct: 21  LRRLVPAAASIADPVAAIVADVRDRGDAAVLELTRAHDTGGAEPKALRVSQSELDAALDS 80

Query: 80  LSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPG--VRCQQVTRPVASVGLYIPGGSAP 137
           L  +++  + VA +N+            +V    G  VR ++V  PV    +Y+PGG AP
Sbjct: 81  LDADVRAGLEVAAQNVGVVAAIGLDDEREVTLGHGQTVRLREV--PVRRAAVYVPGGRAP 138

Query: 138 LFSTVLMLATPASIAGCKKVVLCSPP-PIAD---EILYAAQLCGVQDVFNVGGAQAIAAL 193
             STVLM    A  AG ++VVLCSPP P  D    IL AA L G  +V+ +GGAQAI AL
Sbjct: 139 YPSTVLMGVVTAVTAGVEEVVLCSPPGPDGDLNPAILAAAALAGATEVYRMGGAQAIGAL 198

Query: 194 AFGTESVPKVDKIFGPGNAFVTEAKRQVSQ-RLDGAAIDMPAGPSEVLVIADSGATPDFV 252
           A GT +V  VD I GPGN +V EAKRQVS   L G  ID  AGPS+++V+ D GA     
Sbjct: 199 AHGTATVAPVDLIVGPGNLWVQEAKRQVSAAGLVG--IDGFAGPSDLMVVLDRGADVRLA 256

Query: 253 ASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKD 312
           A DL +QAEHG DS V+ ++P  D A    +A+   L+ +P             L+ T  
Sbjct: 257 ALDLRAQAEHGSDSLVLAVSP--DGA--ALDALSEGLSVVPEP-------GVGALVETAS 305

Query: 313 LAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTY 372
           L   + ++N + PEHL +    A  L   + +AG +F+G     + GDY +G+NH LPT 
Sbjct: 306 LEDALALANAFAPEHLELIGAGAEALAPEVRNAGCLFVGPGGATAFGDYVAGSNHTLPTD 365

Query: 373 GYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVN 428
           G     S L    F++RMT   +  E  + LA     +A AE    H  ++  R+ 
Sbjct: 366 GAARFASGLSARHFRRRMTEVRIPLEAATTLAPAGAAIARAEGFELHAQSMEARMR 421


>UniRef50_B9NIZ3 Histidinol dehydrogenase n=1 Tax=Populus trichocarpa
           RepID=B9NIZ3_POPTR
          Length = 394

 Score =  189 bits (479), Expect = 2e-46,   Method: Compositional matrix adjust.
 Identities = 111/250 (44%), Positives = 155/250 (62%), Gaps = 12/250 (4%)

Query: 31  SITRTVNDILDNVKARGDEALREYSAKFDKTTV---TALKVSAEEIAAASERLSDELKQA 87
           +I + V DIL +V+ RGD A+ EY+A+FD   V    AL+++  E+ AA + L DE + A
Sbjct: 138 AIEQRVADILADVQKRGDAAVLEYTARFDGLQVEGMAALELTQAELKAAFDSLGDEQRDA 197

Query: 88  MAVAVKNIETFHTAQKLPPVD---VETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLM 144
           +  A + + T+H AQK    +        G    Q   P+  VG+Y+PGG A   S+VLM
Sbjct: 198 LTAAAQRVRTYHEAQKRASGESWSYRDADGTLLGQKVTPLDRVGIYVPGGKAAYPSSVLM 257

Query: 145 LATPASIAGCKKVVLCSPPPIADE---ILYAAQLCGVQDVFNVGGAQAIAALAFGTESVP 201
            A PA +AG +++++  P P  ++   +L AA + GV   F +GGAQA+AALA+GT ++P
Sbjct: 258 NAIPAHVAGVQEIIMVVPTPRGEKNALVLAAAYVAGVTRGFTIGGAQAVAALAYGTATIP 317

Query: 202 KVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAE 261
           KVDKI GPGNA+V  AK++V        IDM AGPSE+LV+AD    PD+VA DL SQAE
Sbjct: 318 KVDKITGPGNAYVASAKKRV---FGTVGIDMIAGPSEILVLADGSTPPDWVAMDLFSQAE 374

Query: 262 HGPDSQVILL 271
           H   +Q ILL
Sbjct: 375 HDELAQSILL 384


>UniRef50_A8M914 Histidinol dehydrogenase n=1 Tax=Caldivirga maquilingensis IC-167
           RepID=A8M914_CALMQ
          Length = 399

 Score =  186 bits (471), Expect = 2e-45,   Method: Compositional matrix adjust.
 Identities = 139/414 (33%), Positives = 215/414 (51%), Gaps = 33/414 (7%)

Query: 21  LMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERL 80
           L+R A    + + R V  I+++VK  GDEAL   +++ D   ++++++S  E+ A +  +
Sbjct: 11  LLRKATDMDQYVDR-VRGIINDVKEHGDEALLRLTSELDGVKLSSIELSQSELRALASGI 69

Query: 81  SDELKQAMAVAVKNIETFHTAQKLPPVDVE-TQPGVRCQQVTRPVASVGLYIPGGSAPLF 139
              +++A+   + ++E+F+T  K  P D E    G+R      P++ VGLY+P G    F
Sbjct: 70  EPRVREALDEVMASVESFNTGVK--PRDFEDYHRGLRRGVKWVPLSRVGLYVPKG---YF 124

Query: 140 STVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQDVFNVGGAQAIAALAF 195
           ST++M    A +AG ++++  +PP     I  EI Y A     + VF VGGAQA+AALAF
Sbjct: 125 STLVMTGVLAKVAGVEEIIAVTPPRRDGLIDPEIAYVALRLNAR-VFRVGGAQAVAALAF 183

Query: 196 GTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASD 255
           GTESVP+VDKI GPGNA+V  AK  VS  +    ID   GP+E++  AD G  P  VA D
Sbjct: 184 GTESVPRVDKIIGPGNAYVQAAKLLVSSHV---GIDGVEGPTELVTCADPGIKPITVALD 240

Query: 256 LLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQ 315
           L +Q EH     V++      +      A+E +L++L  A      +N        + ++
Sbjct: 241 LAAQLEHAGAVGVVVTWSEGYLT-----AIEDELSKLTNAPYFSTLVN--------EPSE 287

Query: 316 CVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYT 375
           CV + N+  PEH  I     +  ++ I +AG+V +   +P +  DYA+G +HVLPT G  
Sbjct: 288 CVNVINEVAPEHASIW--GVKIPIEGIRNAGAVSI--MAPSALVDYAAGPSHVLPTGGSA 343

Query: 376 ATCSSLGLADFQKRMT-VQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVN 428
                L   DF K +  V+  S +    L      L   E    H  A+T  +N
Sbjct: 344 RWRGVLTPMDFMKPIAYVEPTSGDEARRLGELGAVLGLREGFRRHSEALTNWIN 397


>UniRef50_C6UN35 Histidinal/histidinol dehydrogenase n=1 Tax=Candidatus Hodgkinia
           cicadicola Dsem RepID=C6UN35_HODCD
          Length = 428

 Score =  177 bits (448), Expect = 1e-42,   Method: Compositional matrix adjust.
 Identities = 130/371 (35%), Positives = 187/371 (50%), Gaps = 10/371 (2%)

Query: 29  SESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAM 88
           S  +      I   V A  D+AL  Y+ + D      L+  A +I    E +  +   ++
Sbjct: 27  SARVKAVAEKISQTVSAYADKALMAYNLRLDGCASRLLRF-APDIDL--ETVDVKALFSL 83

Query: 89  AVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATP 148
            +A+  +   H+ Q      V    G +      PV+SVG+Y+PGG+A   S+V+M   P
Sbjct: 84  KLALDRVAALHSLQLPSSCCVRDALGAKLGFRWTPVSSVGVYVPGGTASYLSSVIMCCVP 143

Query: 149 ASIAGCKKVVLCSP-PPIADEILY--AAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDK 205
           A IAG   + L +P   +A++ L+   A+LCGV  V+  GGA A+AAL+ GT +V KVDK
Sbjct: 144 ARIAGVGHISLATPYSKLANKPLFMACAKLCGVACVYPFGGAHAVAALSVGTRAVRKVDK 203

Query: 206 IFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPD 265
           I GPGNAFV  AK     R+    +D  AGPSE +++AD  A    +A D L Q EH  D
Sbjct: 204 IVGPGNAFVAAAKALAQGRV---GVDCLAGPSEAVIVADGVADAWTLAVDSLCQLEHASD 260

Query: 266 SQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRL-IVTKDLAQCVEISNQYG 324
           +   ++  +A++A RV   V   +    R  TA ++ +A  + +V   +A      N   
Sbjct: 261 ALTAVVVSSAELASRVRANVALLVRSARRRRTAERSWSAGGVSVVCCCVADAAATVNALA 320

Query: 325 PEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLA 384
            EH+        +L+  +TSAG+VFLG  SP   GDY  GTNH LPT       S L + 
Sbjct: 321 SEHVQACVLKPAKLLTKLTSAGAVFLGGGSPIVVGDYVGGTNHTLPTASGAKFASGLSVL 380

Query: 385 DFQKRMTVQEL 395
           DF KR  V  L
Sbjct: 381 DFMKRTYVTWL 391


>UniRef50_A8A9G5 Histidinol dehydrogenase n=1 Tax=Ignicoccus hospitalis KIN4/I
           RepID=A8A9G5_IGNH4
          Length = 404

 Score =  167 bits (422), Expect = 8e-40,   Method: Compositional matrix adjust.
 Identities = 132/399 (33%), Positives = 194/399 (48%), Gaps = 37/399 (9%)

Query: 36  VNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAMAVAVKNI 95
           V  ++  VKARG EA+++Y+  FD      + +S E+ A+ S+   + L       ++ +
Sbjct: 38  VMPVVKEVKARGLEAVKKYNKAFDNYE-GCVSLSQEDFASYSK---ESLVSLFEEVLEQL 93

Query: 96  ETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCK 155
             FH  Q  P     +  GVR   + RPV  +G Y+PGG  P  ST LM A  A   G K
Sbjct: 94  SAFHK-QTAPKDSAFSSKGVRAVTLWRPVERLGAYVPGGLYPYPSTALMTAGVAKALGVK 152

Query: 156 KVVLCSPPPIA-DEILYAAQLCG-VQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAF 213
           +V + +PP  A  E++ +A L   V  V   GGA  ++ALA+    V    K+ GPG  +
Sbjct: 153 EVTVATPPKFATSEVMASAFLASKVDSVLAAGGAHGVSALAY----VAGAHKVVGPGGPY 208

Query: 214 VTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTP 273
           V  AK  VS  +    IDM AGP+E+ VIADS A P+ VA D+L+QAEHGP S  +L++ 
Sbjct: 209 VQAAKLLVSVDVP---IDMIAGPTELAVIADSSADPEEVAYDMLAQAEHGPTSFALLVST 265

Query: 274 AADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTR 333
              +   V + V        + E     L A+   V +DL +   + ++  PEH+ +   
Sbjct: 266 DEGLVLEVEKRV--------KGEEVEGGLYAT---VVRDLEEAKRLVSELAPEHVSVYAE 314

Query: 334 NARELVDSITS--AGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMT 391
                V    S  A S FL         DY++G NHVLPT G+      LG  DF +  T
Sbjct: 315 TYEPPVAGAASFKAPSPFL---------DYSAGPNHVLPTSGWAKARGPLGPVDFMRWTT 365

Query: 392 VQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNAL 430
           + E+  E    L    E LA  E +  H  A+  +++ +
Sbjct: 366 LVEVFPEAADLLKLAAE-LARLEGMKYHAKAIEYKLSKI 403


>UniRef50_Q8ZY17 Histidinol dehydrogenase n=5 Tax=Thermoproteaceae RepID=HISX_PYRAE
          Length = 368

 Score =  123 bits (309), Expect = 1e-26,   Method: Compositional matrix adjust.
 Identities = 109/385 (28%), Positives = 180/385 (46%), Gaps = 46/385 (11%)

Query: 32  ITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAMAVA 91
           +  +V  I+D+V++ G +A  EYS + D        V+ E       +  D    + A+A
Sbjct: 8   VLESVWKIVDDVQSGGLKAALEYSKRLDG-------VAPEPHLVTPRQGGDPEVVSAALA 60

Query: 92  VKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASI 151
                    ++  PP  V+   G+  Q + +PV    LY+P   A   ST++MLA PA +
Sbjct: 61  AAKSLEALYSRISPPAAVDFYGGILRQILWKPVRRAALYVP---ARYISTLVMLAVPARL 117

Query: 152 AGCKKVVLCSPP-PIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPG 210
           AG ++V + +PP  +++E+L  A+  GV+ V  +GG   +A   F       VD + GPG
Sbjct: 118 AGVEEVYVVTPPRGVSEELLAVAKELGVKAVLALGGPHGLAYAVFHM----GVDVVAGPG 173

Query: 211 NAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVIL 270
             +V  AK  +SQ +    ID   GP+E LVI   G  P+      L+Q EHGP S   L
Sbjct: 174 GLYVQAAKYILSQYV---GIDGIEGPTE-LVIYAEGVPPEVAVRGALAQLEHGPTSFAYL 229

Query: 271 LTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQCVEISNQYGPEHLII 330
           L+P  ++ ++  E   R+            ++   ++     + + V   ++  PEHL +
Sbjct: 230 LSPDGELLKKAEELYVRERT---------SSMGPLKVKKVGGIDEAVSFIDEIAPEHLEV 280

Query: 331 QTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYT---------ATCSSL 381
             R  RE+   + + G+V +   SP    DY +G +HVLPT G           A    +
Sbjct: 281 WGR--REVAYRVRNVGAVSVNMPSPYL--DYVAGISHVLPTGGTARWRGVITPLAFMKPI 336

Query: 382 GLADFQKRMTVQELSK-----EGFS 401
           G+A+    +T++E ++     EGF 
Sbjct: 337 GIAEAVGELTLREAARKLAEYEGFK 361


>UniRef50_P72946 Putative histidinol dehydrogenase 2 n=1 Tax=Synechocystis sp. PCC
           6803 RepID=HISX2_SYNY3
          Length = 409

 Score =  115 bits (289), Expect = 2e-24,   Method: Compositional matrix adjust.
 Identities = 92/324 (28%), Positives = 149/324 (45%), Gaps = 7/324 (2%)

Query: 67  KVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVE-TQPGVRCQQVTRPVA 125
           +VS  E+ AA +R+S E    +  A   +E  +  Q LP   V   + G    Q   PV 
Sbjct: 50  RVSGAELDAAYQRISQEKLSVIRQACAALEQVYRPQ-LPKTQVSFPEDGTVRGQRFYPVR 108

Query: 126 SVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVFNVG 185
             G Y+          +L     A   G  + VL +   I+  IL AAQ  G+++++   
Sbjct: 109 RAGFYLEAKRGDALGNLLRQGMLAKTVGVAERVLVTET-ISSTILVAAQEMGIEEIYLAA 167

Query: 186 GAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADS 245
           G  AIA L +G +++  V+ I G G   V  AK+ VS  +    ID     + ++V+AD 
Sbjct: 168 GVPAIAMLTWGAKNIAPVESITGAGCPRVMAAKQLVSGVV---TIDQTLARTNLMVLADG 224

Query: 246 GATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNAS 305
            A   ++A DLL+ AE  P++  +LLT   ++   V ++V R   E   +    +AL   
Sbjct: 225 EANGQWLALDLLAHAEQYPNASAVLLTDRLELGEEVIQSVNRYCREQEHSVHTEKALAHY 284

Query: 306 RLI-VTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASG 364
            L+ + +DL  C    N++ P  L++   +   +V+ +  A  +++G  SP   G Y SG
Sbjct: 285 GLVAIVEDLEACGSWINEFCPHILLLAMEDPWTMVEKVQRAREIYIGHRSPSILGHYLSG 344

Query: 365 TNHVLPTYGYTATCSSLGLADFQK 388
            N +    G  AT S L    F +
Sbjct: 345 ANRLQTQDGAMATASELAFHCFLR 368


>UniRef50_A3J633 Histidinol dehydrogenase (Fragment) n=1 Tax=Flavobacteria bacterium
           BAL38 RepID=A3J633_9FLAO
          Length = 136

 Score =  105 bits (262), Expect = 3e-21,   Method: Composition-based stats.
 Identities = 56/128 (43%), Positives = 82/128 (64%), Gaps = 1/128 (0%)

Query: 15  EQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIA 74
           E   ++  RP  + S+ +  TV  I   V+ +G++A+ +Y++ FD  T+  ++V+ EEI 
Sbjct: 10  ETWLEICKRPTQTFSD-VEETVKQIFKKVQQKGNKAIAKYTSFFDGVTLENIQVTPEEIE 68

Query: 75  AASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGG 134
            A + ++ ELK+A+ +A  NIE FH AQK   + VET  GV C Q  RP+  VGLYIPGG
Sbjct: 69  LAKKEVATELKKAIQLAKSNIEQFHAAQKTDKIVVETTIGVTCWQEKRPIQKVGLYIPGG 128

Query: 135 SAPLFSTV 142
           +APLFSTV
Sbjct: 129 TAPLFSTV 136


>UniRef50_B8NVQ6 Histidinol dehydrogenase, putative n=1 Tax=Aspergillus flavus
           NRRL3357 RepID=B8NVQ6_ASPFN
          Length = 224

 Score =  105 bits (262), Expect = 4e-21,   Method: Compositional matrix adjust.
 Identities = 78/244 (31%), Positives = 113/244 (46%), Gaps = 39/244 (15%)

Query: 189 AIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGAT 248
           A+AA+A GTE++ KVD + G GN FV E KRQ+   +    ID+ AGP+EVLV+AD  A 
Sbjct: 13  AVAAIAVGTETIRKVDFLAGTGNRFVAEGKRQLFGEV---GIDLFAGPTEVLVLADETAD 69

Query: 249 PDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLA--ELPRAETARQALNA-S 305
           P  VA DL+SQA HGPD+  +L+T    + R   E V + L+  +L   + A+ + +A  
Sbjct: 70  PFTVAMDLISQAGHGPDTPAVLITTCPKVGRETIEIVNKLLSATDLSTPDVAKVSWDAFG 129

Query: 306 RLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGT 365
            +I+   L +  E+ + Y  E + +                                 GT
Sbjct: 130 EVIIVDTLEELWELGDHYASEQVQV--------------------------------IGT 157

Query: 366 NHVLPTYGYTATCSSLGLADFQKRMTVQELS-KEGFSALASTIETLAAAERLTAHKNAVT 424
           NH+LPT         L +  + K  T QE++  E    L       A  ER  A   +  
Sbjct: 158 NHILPTRTTARYTGGLWVGKYLKTCTYQEVTLPESSGKLGRLCGRAARPERFEAPARSGD 217

Query: 425 LRVN 428
           LR N
Sbjct: 218 LRAN 221


>UniRef50_UPI0001909A69 histidinol dehydrogenase n=1 Tax=Rhizobium etli IE4771
           RepID=UPI0001909A69
          Length = 287

 Score =  101 bits (251), Expect = 6e-20,   Method: Compositional matrix adjust.
 Identities = 67/170 (39%), Positives = 96/170 (56%), Gaps = 8/170 (4%)

Query: 29  SESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA---LKVSAEEIAAASERLSDELK 85
           SE +      I+D+VKARGD AL    A   +   +    ++V+ EEI AA E +  E+ 
Sbjct: 40  SEDVNAVARAIIDDVKARGDVALCRIFADIRRHRFSPPVPMRVTPEEIDAAVEAVPSEVL 99

Query: 86  QAMAVAVKNIETFHTAQKLPPVDV-ETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLM 144
            A+ +A   IE+ H  Q LP  D+ E   GVR       + +VGLY+PGG+A   S+VLM
Sbjct: 100 GALKLAALRIESHHRRQ-LPKDDIYEDDLGVRLGSRWTAIEAVGLYVPGGTASYPSSVLM 158

Query: 145 LATPASIAGCKKVVLCSPP---PIADEILYAAQLCGVQDVFNVGGAQAIA 191
            A PA +AG  ++V+  P     +   +L AA+L GV +++ VGGAQAIA
Sbjct: 159 NAVPAKVAGVDRIVIAVPATGGAVNPAVLAAARLAGVTEIYRVGGAQAIA 208


>UniRef50_C7H2J0 Histidinol dehydrogenase n=1 Tax=Faecalibacterium prausnitzii
           A2-165 RepID=C7H2J0_9FIRM
          Length = 162

 Score = 99.0 bits (245), Expect = 3e-19,   Method: Compositional matrix adjust.
 Identities = 50/137 (36%), Positives = 77/137 (56%)

Query: 26  ISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELK 85
           I A +++   V+ I+  V+ARGDEAL+EY+ KFD   +  L+V+  EI  A   +     
Sbjct: 20  IRAEKNVEDVVDGIIAEVRARGDEALKEYALKFDGAKIDDLQVTQAEIDEAFANMDPYFL 79

Query: 86  QAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLML 145
           + +  A  NIE+FH  Q      +  +PG+   Q   P+   G+Y+PGG+A   STVLM 
Sbjct: 80  ETLREAAANIESFHRQQVHKNFVINEKPGIVLGQKYTPIEKAGVYVPGGTAAYPSTVLMD 139

Query: 146 ATPASIAGCKKVVLCSP 162
             PA +AG  ++V+ +P
Sbjct: 140 VIPAKVAGVSEIVMTTP 156


>UniRef50_C5GHZ5 Histidinol dehydrogenase n=2 Tax=Ajellomyces dermatitidis
           RepID=C5GHZ5_AJEDR
          Length = 281

 Score = 91.7 bits (226), Expect = 5e-17,   Method: Compositional matrix adjust.
 Identities = 62/183 (33%), Positives = 91/183 (49%), Gaps = 35/183 (19%)

Query: 149 ASIAGCKKVVLCSPP---PIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDK 205
           + +AG   V +C+PP    I +       L G  ++F +GGAQAIA +A GTES+ KVD 
Sbjct: 64  SKVAGVNHVTMCTPPINGKIPNATTATTHLVGANEIFILGGAQAIAGMAVGTESIRKVDS 123

Query: 206 IFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPD 265
           I   G                   +D+ AGP+EV         P   A+ LLSQAEHGPD
Sbjct: 124 IAEIG-------------------VDLFAGPTEV---------P---ATHLLSQAEHGPD 152

Query: 266 SQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKD-LAQCVEISNQYG 324
           S  +L+T + D A++V   ++R L  L  A  A  A  + R +V  D + +   + ++Y 
Sbjct: 153 SPAVLITTSEDSAKQVMTLIDRFLETLSTAAIASTAWRSFREVVIVDSIDEAYALGDEYA 212

Query: 325 PEH 327
            +H
Sbjct: 213 FDH 215


>UniRef50_D1ND55 Histidinol dehydrogenase (Fragment) n=1 Tax=Haemophilus influenzae
           HK1212 RepID=D1ND55_HAEIN
          Length = 104

 Score = 76.3 bits (186), Expect = 2e-12,   Method: Composition-based stats.
 Identities = 43/99 (43%), Positives = 60/99 (60%), Gaps = 1/99 (1%)

Query: 5   TIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVT 64
           TII WN  +  ++R+++MRP     ++I + VN I +NV   GD AL E   KFD   + 
Sbjct: 3   TII-WNHLSETEKRKVIMRPVQQNGKNIQQAVNAIRENVAYNGDRALFELCEKFDGVKLD 61

Query: 65  ALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQK 103
            L VS +EI AAS R+S +L+ A+  A  NIE FH AQ+
Sbjct: 62  KLIVSVDEIQAASSRISVKLRNAIEQAKTNIEAFHKAQQ 100


>UniRef50_B4CYY3 NAD+ oxidoreductase n=1 Tax=Chthoniobacter flavus Ellin428
           RepID=B4CYY3_9BACT
          Length = 162

 Score = 61.6 bits (148), Expect = 5e-08,   Method: Compositional matrix adjust.
 Identities = 38/129 (29%), Positives = 66/129 (51%), Gaps = 8/129 (6%)

Query: 22  MRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA--LKVSAEEIAAASER 79
           ++ +  A   + +TV D+L+ ++  GD AL E++ +F    +TA  L+V+ +       +
Sbjct: 18  LKRSAEAHPQVRKTVQDVLEAIRTEGDSALLEFTERFGGPRLTAKQLRVTGKP------K 71

Query: 80  LSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLF 139
           +  E K+A+A A  N+  F          ++   G    +   P   VG+Y+PGG+APL 
Sbjct: 72  VDAETKEAVATAHANVLAFARKSLRENWTMKNAQGGLVGERFDPFKRVGIYVPGGTAPLV 131

Query: 140 STVLMLATP 148
           ST +M  TP
Sbjct: 132 STAVMTVTP 140


>UniRef50_UPI0001696B01 histidinol dehydrogenase n=2 Tax=Listeria monocytogenes
           RepID=UPI0001696B01
          Length = 123

 Score = 60.8 bits (146), Expect = 8e-08,   Method: Compositional matrix adjust.
 Identities = 35/93 (37%), Positives = 54/93 (58%)

Query: 36  VNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAMAVAVKNI 95
           V  I++ VK  GD+AL ++++KFD   +T L+V A +I AAS ++      A+  A  NI
Sbjct: 31  VKTIIEKVKTAGDQALFDFTSKFDGVGLTELRVPAADIQAASAKIEPAFLDALQQAKVNI 90

Query: 96  ETFHTAQKLPPVDVETQPGVRCQQVTRPVASVG 128
           E+FH+ QK        + GV   Q+ RP+ +VG
Sbjct: 91  ESFHSKQKQHAFLDSEKDGVIRGQLIRPLETVG 123


>UniRef50_D1KBK9 Histidinol dehydrogenase n=1 Tax=uncultured SUP05 cluster
          bacterium RepID=D1KBK9_9GAMM
          Length = 146

 Score = 44.3 bits (103), Expect = 0.008,   Method: Compositional matrix adjust.
 Identities = 26/87 (29%), Positives = 52/87 (59%), Gaps = 4/87 (4%)

Query: 15 EQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDK---TTVTALKVSAE 71
          E+  +LL   ++S+++ I +TV+DI+ N++  GD+AL +Y+ KFD    + ++AL V   
Sbjct: 14 EKLSKLLAWESVSSTD-IAQTVDDIIANIRQNGDQALIDYTNKFDGMDVSDISALTVDQS 72

Query: 72 EIAAASERLSDELKQAMAVAVKNIETF 98
           +  A + L+++ K A+  A   +  +
Sbjct: 73 ALKKAFDSLAEKEKTALQSAADRVRDY 99


Searching..................................................done


Results from round 2


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value
Sequences used in model and found again:

UniRef50_Q5E638 Histidinol dehydrogenase n=29 Tax=Bacteria RepID...   622   e-177
UniRef50_Q4QN74 Histidinol dehydrogenase n=38 Tax=cellular organ...   602   e-170
UniRef50_Q492K3 Histidinol dehydrogenase n=542 Tax=Proteobacteri...   598   e-169
UniRef50_P59398 Histidinol dehydrogenase n=5 Tax=Buchnera aphidi...   589   e-167
UniRef50_D1PYE8 Histidinol dehydrogenase n=2 Tax=Prevotella RepI...   585   e-166
UniRef50_P62456 Histidinol dehydrogenase n=127 Tax=Bacteria RepI...   583   e-165
UniRef50_UPI00019859BD PREDICTED: hypothetical protein n=1 Tax=V...   577   e-163
UniRef50_D1IQ57 Histidinol dehydrogenase (Fragment) n=1 Tax=Viti...   576   e-163
UniRef50_O26327 Histidinol dehydrogenase n=6 Tax=Euryarchaeota R...   574   e-162
UniRef50_Q8R882 Histidinol dehydrogenase n=7 Tax=Clostridia RepI...   573   e-162
UniRef50_Q39YP7 Histidinol dehydrogenase n=54 Tax=Bacteria RepID...   570   e-161
UniRef50_Q9C5U8 Histidinol dehydrogenase, chloroplastic n=34 Tax...   570   e-161
UniRef50_Q58851 Histidinol dehydrogenase n=16 Tax=Euryarchaeota ...   569   e-161
UniRef50_Q02136 Histidinol dehydrogenase n=9 Tax=Bacteria RepID=...   568   e-160
UniRef50_Q722Y3 Histidinol dehydrogenase n=20 Tax=Firmicutes Rep...   567   e-160
UniRef50_A8RCE7 Putative uncharacterized protein n=1 Tax=Eubacte...   565   e-160
UniRef50_Q465R4 Histidinol dehydrogenase n=7 Tax=Euryarchaeota R...   564   e-159
UniRef50_D1CF70 Histidinol dehydrogenase n=1 Tax=Thermobaculum t...   563   e-159
UniRef50_C6Y3G2 Histidinol dehydrogenase n=6 Tax=cellular organi...   563   e-159
UniRef50_Q30TA4 Histidinol dehydrogenase n=16 Tax=Epsilonproteob...   561   e-158
UniRef50_C0GFZ9 Histidinol dehydrogenase n=1 Tax=Dethiobacter al...   561   e-158
UniRef50_Q46J19 Histidinol dehydrogenase n=60 Tax=Bacteria RepID...   560   e-158
UniRef50_B0TY46 Histidinol dehydrogenase n=2 Tax=Francisella phi...   559   e-158
UniRef50_A9NV24 Histidinol dehydrogenase n=2 Tax=Spermatophyta R...   554   e-156
UniRef50_D0JBA3 Histidinol dehydrogenase n=2 Tax=Blattabacterium...   554   e-156
UniRef50_Q4ZNV9 Histidinol dehydrogenase n=116 Tax=Bacteria RepI...   553   e-156
UniRef50_Q2NHT1 HisD n=1 Tax=Methanosphaera stadtmanae DSM 3091 ...   553   e-156
UniRef50_Q8YSM8 Histidinol dehydrogenase 1 n=16 Tax=Bacteria Rep...   552   e-156
UniRef50_P59399 Histidinol dehydrogenase n=14 Tax=Bacteria RepID...   552   e-155
UniRef50_Q6FEC8 Histidinol dehydrogenase n=50 Tax=Bacteria RepID...   551   e-155
UniRef50_B9D1F9 Histidinol dehydrogenase n=2 Tax=Campylobacter R...   551   e-155
UniRef50_P00815 Histidinol dehydrogenase n=17 Tax=cellular organ...   551   e-155
UniRef50_C9LTV1 Histidinol dehydrogenase n=1 Tax=Selenomonas spu...   550   e-155
UniRef50_C0QG33 Histidinol dehydrogenase n=4 Tax=Deltaproteobact...   549   e-155
UniRef50_B2KCM4 Histidinol dehydrogenase n=1 Tax=Elusimicrobium ...   548   e-154
UniRef50_Q1Q2D0 Histidinol dehydrogenase n=1 Tax=Candidatus Kuen...   545   e-153
UniRef50_D0RRH1 Histidinol dehydrogenase n=1 Tax=alpha proteobac...   545   e-153
UniRef50_C9KKX1 Histidinol dehydrogenase n=1 Tax=Mitsuokella mul...   544   e-153
UniRef50_C4V2I6 Histidinol dehydrogenase n=1 Tax=Selenomonas flu...   541   e-152
UniRef50_Q2PPB3 Histidine biosynthesis trifunctional protein n=1...   541   e-152
UniRef50_B3WED5 Histidinol dehydrogenase n=21 Tax=Bacilli RepID=...   541   e-152
UniRef50_Q5FS83 Histidinol dehydrogenase n=3 Tax=Bacteria RepID=...   541   e-152
UniRef50_Q5ZW87 Histidinol dehydrogenase n=6 Tax=Legionella RepI...   540   e-152
UniRef50_D2RJQ0 Histidinol dehydrogenase n=7 Tax=Firmicutes RepI...   539   e-152
UniRef50_Q3AR25 Histidinol dehydrogenase n=13 Tax=Bacteria RepID...   539   e-152
UniRef50_C7LV94 Histidinol dehydrogenase n=6 Tax=Desulfovibriona...   537   e-151
UniRef50_B2A652 Histidinol dehydrogenase n=1 Tax=Natranaerobius ...   537   e-151
UniRef50_B3TCH3 Putative Histidinol dehydrogenase n=1 Tax=uncult...   536   e-151
UniRef50_C1PFR7 Histidinol dehydrogenase n=1 Tax=Bacillus coagul...   534   e-150
UniRef50_P62457 Histidinol dehydrogenase n=27 Tax=cellular organ...   532   e-150
UniRef50_Q186D5 Histidinol dehydrogenase n=9 Tax=Bacteria RepID=...   531   e-149
UniRef50_C3XDE7 Histidinol dehydrogenase n=1 Tax=Helicobacter bi...   531   e-149
UniRef50_Q3J079 Histidinol dehydrogenase 1 n=26 Tax=Proteobacter...   530   e-149
UniRef50_Q46WL2 Histidinol dehydrogenase 1 n=202 Tax=Bacteria Re...   530   e-149
UniRef50_Q313T7 Histidinol dehydrogenase n=7 Tax=Deltaproteobact...   529   e-148
UniRef50_D1YWF4 Histidinol dehydrogenase n=1 Tax=Methanocella pa...   528   e-148
UniRef50_Q4P7D9 Putative uncharacterized protein n=3 Tax=Eukaryo...   527   e-148
UniRef50_Q9P777 Histidinol dehydrogenase n=71 Tax=cellular organ...   525   e-147
UniRef50_A9A0A6 Histidinol dehydrogenase n=2 Tax=Desulfobacterac...   522   e-146
UniRef50_Q87C29 Histidinol dehydrogenase n=66 Tax=cellular organ...   521   e-146
UniRef50_B9KYT3 Histidinol dehydrogenase n=1 Tax=Thermomicrobium...   521   e-146
UniRef50_Q3B5E3 Histidinol dehydrogenase n=8 Tax=Chlorobiaceae R...   520   e-146
UniRef50_Q4FQF8 Histidinol dehydrogenase n=6 Tax=Proteobacteria ...   520   e-146
UniRef50_C7NG13 Histidinol dehydrogenase n=2 Tax=Bacteria RepID=...   519   e-146
UniRef50_Q3ZXL7 Histidinol dehydrogenase n=5 Tax=Dehalococcoides...   518   e-145
UniRef50_Q9X0D1 Histidinol dehydrogenase n=6 Tax=Thermotogaceae ...   517   e-145
UniRef50_A5D1M4 Histidinol dehydrogenase n=1 Tax=Pelotomaculum t...   511   e-143
UniRef50_B3DXR9 Histidinol dehydrogenase n=1 Tax=Methylacidiphil...   510   e-143
UniRef50_Q01ZU1 Histidinol dehydrogenase n=1 Tax=Candidatus Soli...   508   e-142
UniRef50_A3EUM9 Histidinol dehydrogenase n=3 Tax=Leptospirillum ...   508   e-142
UniRef50_C9RN89 Histidinol dehydrogenase n=1 Tax=Fibrobacter suc...   504   e-141
UniRef50_P62460 Histidinol dehydrogenase n=15 Tax=Bacteria RepID...   504   e-141
UniRef50_C8WUX6 Histidinol dehydrogenase n=2 Tax=Alicyclobacillu...   503   e-141
UniRef50_D0LM64 Histidinol dehydrogenase n=2 Tax=Nannocystineae ...   502   e-140
UniRef50_B1YL14 Histidinol dehydrogenase n=1 Tax=Exiguobacterium...   498   e-139
UniRef50_Q4A044 Histidinol dehydrogenase n=62 Tax=Staphylococcus...   496   e-139
UniRef50_UPI00016BFCCC histidinol dehydrogenase n=1 Tax=Epulopis...   495   e-138
UniRef50_C4L171 Histidinol dehydrogenase n=1 Tax=Exiguobacterium...   494   e-138
UniRef50_Q5WIU9 Histidinol dehydrogenase 1 n=52 Tax=cellular org...   491   e-137
UniRef50_Q483H8 Histidinol dehydrogenase 2 n=15 Tax=Proteobacter...   490   e-137
UniRef50_A6UA68 Histidinol dehydrogenase n=4 Tax=Proteobacteria ...   487   e-136
UniRef50_B1H0F0 Histidinol dehydrogenase n=1 Tax=uncultured Term...   487   e-136
UniRef50_Q8TXG3 Histidinol dehydrogenase n=1 Tax=Methanopyrus ka...   487   e-136
UniRef50_Q7UX39 Histidinol dehydrogenase n=6 Tax=Planctomycetace...   486   e-136
UniRef50_P73058 Histidinol dehydrogenase 1 n=11 Tax=Cyanobacteri...   485   e-135
UniRef50_A1ZJE8 Histidinol dehydrogenase n=1 Tax=Microscilla mar...   485   e-135
UniRef50_Q4FNE2 Histidinol dehydrogenase 1 n=3 Tax=Candidatus Pe...   484   e-135
UniRef50_B3T638 Histidinol dehydrogenase n=1 Tax=uncultured mari...   483   e-135
UniRef50_Q13I58 Histidinol dehydrogenase n=22 Tax=cellular organ...   482   e-134
UniRef50_UPI00017455E1 Histidinol dehydrogenase n=1 Tax=Verrucom...   481   e-134
UniRef50_D0XPF3 Histidinol dehydrogenase n=1 Tax=Brevundimonas s...   481   e-134
UniRef50_Q67KH6 Histidinol dehydrogenase n=1 Tax=Symbiobacterium...   481   e-134
UniRef50_B4W8G9 Histidinol dehydrogenase n=2 Tax=Caulobacteracea...   480   e-134
UniRef50_D1N997 Histidinol dehydrogenase n=2 Tax=Lentisphaerae R...   479   e-134
UniRef50_Q64EP7 Histidinol dehydrogenase n=2 Tax=environmental s...   478   e-133
UniRef50_Q4JW59 Histidinol dehydrogenase n=104 Tax=Actinobacteri...   473   e-132
UniRef50_A9A5X6 Histidinol dehydrogenase n=2 Tax=Thaumarchaeota ...   472   e-131
UniRef50_A3Q131 Histidinol dehydrogenase n=6 Tax=Mycobacterium R...   471   e-131
UniRef50_Q1AX10 Histidinol dehydrogenase n=1 Tax=Rubrobacter xyl...   471   e-131
UniRef50_B0S9F2 Histidinol dehydrogenase n=6 Tax=Leptospira RepI...   469   e-131
UniRef50_A4QA32 Histidinol dehydrogenase n=16 Tax=cellular organ...   469   e-131
UniRef50_D2R570 Histidinol dehydrogenase n=1 Tax=Pirellula stale...   468   e-130
UniRef50_Q2HFX2 Putative uncharacterized protein n=1 Tax=Chaetom...   468   e-130
UniRef50_D2RSH8 Histidinol dehydrogenase n=1 Tax=Haloterrigena t...   468   e-130
UniRef50_B6A0U7 Histidinol dehydrogenase n=1 Tax=Rhizobium legum...   467   e-130
UniRef50_Q3IQR5 Histidinol dehydrogenase n=10 Tax=Halobacteriace...   465   e-129
UniRef50_D1B7M0 Histidinol dehydrogenase n=2 Tax=Bacteria RepID=...   465   e-129
UniRef50_B2UMH6 Histidinol dehydrogenase n=3 Tax=Verrucomicrobia...   463   e-129
UniRef50_C1FAE2 Histidinol dehydrogenase n=1 Tax=Acidobacterium ...   460   e-128
UniRef50_C0GVA3 Histidinol dehydrogenase n=1 Tax=Desulfonatronos...   459   e-128
UniRef50_Q5YYQ0 Histidinol dehydrogenase n=8 Tax=Actinomycetales...   459   e-128
UniRef50_Q82AA6 Histidinol dehydrogenase n=29 Tax=Actinobacterid...   459   e-127
UniRef50_C0G418 Histidinol dehydrogenase n=2 Tax=Rhizobiales Rep...   458   e-127
UniRef50_Q5JFR5 Histidinol dehydrogenase n=9 Tax=cellular organi...   458   e-127
UniRef50_Q1D4L9 Histidinol dehydrogenase n=2 Tax=Cystobacterinea...   455   e-126
UniRef50_B8E2C3 Histidinol dehydrogenase n=1 Tax=Dictyoglomus tu...   454   e-126
UniRef50_Q1IKB6 Histidinol dehydrogenase n=1 Tax=Candidatus Kori...   453   e-126
UniRef50_B5YE85 Histidinol dehydrogenase n=1 Tax=Dictyoglomus th...   449   e-125
UniRef50_O33775 Histidinol dehydrogenase n=12 Tax=Sulfolobaceae ...   446   e-124
UniRef50_Q46N53 Histidinol dehydrogenase 2 n=50 Tax=root RepID=H...   443   e-123
UniRef50_C7LZ86 Histidinol dehydrogenase n=1 Tax=Acidimicrobium ...   439   e-122
UniRef50_Q0AP81 Histidinol dehydrogenase, Histidinol-phosphatase...   439   e-121
UniRef50_A0R401 Histidinol dehydrogenase n=2 Tax=Actinomycetales...   434   e-120
UniRef50_A9G5W4 HisD protein n=1 Tax=Sorangium cellulosum 'So ce...   431   e-119
UniRef50_C7RAI8 Histidinol dehydrogenase n=1 Tax=Kangiella koree...   429   e-119
UniRef50_C1A4M1 Histidinol dehydrogenase n=1 Tax=Gemmatimonas au...   422   e-116
UniRef50_B1ZNB2 Histidinol dehydrogenase n=3 Tax=Verrucomicrobia...   422   e-116
UniRef50_C9SQK1 Histidine biosynthesis trifunctional protein n=1...   411   e-113
UniRef50_B5YLM0 Histidinol dehydrogenase n=1 Tax=Thalassiosira p...   407   e-112
UniRef50_UPI0001C3165E histidinol dehydrogenase n=1 Tax=Conexiba...   394   e-108
UniRef50_B7FPZ7 Histidinol dehydrogenase (Fragment) n=3 Tax=Euka...   379   e-103
UniRef50_A8M914 Histidinol dehydrogenase n=1 Tax=Caldivirga maqu...   374   e-102
UniRef50_C6UN35 Histidinal/histidinol dehydrogenase n=1 Tax=Cand...   364   3e-99
UniRef50_A8A9G5 Histidinol dehydrogenase n=1 Tax=Ignicoccus hosp...   347   4e-94
UniRef50_B9NIZ3 Histidinol dehydrogenase n=1 Tax=Populus trichoc...   329   9e-89
UniRef50_P72946 Putative histidinol dehydrogenase 2 n=1 Tax=Syne...   298   2e-79
UniRef50_Q8ZY17 Histidinol dehydrogenase n=5 Tax=Thermoproteacea...   297   8e-79
UniRef50_B8NVQ6 Histidinol dehydrogenase, putative n=1 Tax=Asper...   229   1e-58
UniRef50_UPI0001909A69 histidinol dehydrogenase n=1 Tax=Rhizobiu...   206   2e-51
UniRef50_C7H2J0 Histidinol dehydrogenase n=1 Tax=Faecalibacteriu...   201   3e-50
UniRef50_C5GHZ5 Histidinol dehydrogenase n=2 Tax=Ajellomyces der...   187   7e-46
UniRef50_A3J633 Histidinol dehydrogenase (Fragment) n=1 Tax=Flav...   157   7e-37
UniRef50_B4CYY3 NAD+ oxidoreductase n=1 Tax=Chthoniobacter flavu...   134   5e-30
UniRef50_UPI0001696B01 histidinol dehydrogenase n=2 Tax=Listeria...   119   3e-25
UniRef50_D1ND55 Histidinol dehydrogenase (Fragment) n=1 Tax=Haem...   117   8e-25

Sequences not found previously or not previously below threshold:

UniRef50_D1KBK9 Histidinol dehydrogenase n=1 Tax=uncultured SUP0...    83   2e-14
UniRef50_C7ZHH7 Putative uncharacterized protein n=1 Tax=Nectria...    76   2e-12
UniRef50_C0S8B7 Histidinol dehydrogenase n=1 Tax=Paracoccidioide...    62   3e-08
UniRef50_UPI00016988E7 histidinol dehydrogenase n=1 Tax=Endorift...    57   1e-06
UniRef50_C8S5L7 Putative uncharacterized protein n=1 Tax=Rhodoba...    53   2e-05
UniRef50_D2MHU6 Putative uncharacterized protein (Fragment) n=1 ...    53   2e-05
UniRef50_B8FPV4 Putative cell wall binding repeat 2-containing p...    42   0.058

>UniRef50_Q5E638 Histidinol dehydrogenase n=29 Tax=Bacteria RepID=HISX_VIBF1
          Length = 439

 Score =  622 bits (1606), Expect = e-177,   Method: Composition-based stats.
 Identities = 275/424 (64%), Positives = 327/424 (77%)

Query: 9   WNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKV 68
           W S +  QQ  +L RPAI+   +IT  V  +++ VK  GD  +   + KFD     +++V
Sbjct: 6   WQSLSDSQQDTVLQRPAITEGANITAAVTSVINTVKQEGDAGVFALTEKFDGVKPDSIRV 65

Query: 69  SAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVG 128
           S  EI AAS+RLS+E+K A+  A  NI  FH AQK  PV VETQPGV C+Q+T P+  VG
Sbjct: 66  SNAEIEAASDRLSEEMKTALKQAYSNISKFHQAQKPQPVKVETQPGVICEQITMPINKVG 125

Query: 129 LYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVFNVGGAQ 188
           LYIPGGSAPL STVLML  PA IAGC KVVLCSPPPIADEILY A+LC + +V+N+GGAQ
Sbjct: 126 LYIPGGSAPLPSTVLMLGIPAQIAGCHKVVLCSPPPIADEILYVAKLCKIDEVYNIGGAQ 185

Query: 189 AIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGAT 248
           A+AA+A+GTESV KVDKIFGPGNA+VTEAKRQVS    GAAIDMPAGPSEVLVIAD  A 
Sbjct: 186 AVAAMAYGTESVSKVDKIFGPGNAYVTEAKRQVSNDFRGAAIDMPAGPSEVLVIADESAD 245

Query: 249 PDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLI 308
           PDF+A+DLLSQAEHGPDSQV+L+TP+  +A +VA+AVERQL EL R + ARQAL +S LI
Sbjct: 246 PDFIAADLLSQAEHGPDSQVVLVTPSPIIADQVADAVERQLKELSREDIARQALGSSLLI 305

Query: 309 VTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHV 368
           V   L QCV ISN YGPEHLI+QT+N REL+  + +AGS+FLGD+SPESAGDYASGTNHV
Sbjct: 306 VADSLTQCVSISNFYGPEHLIVQTKNPRELLPLLDNAGSIFLGDYSPESAGDYASGTNHV 365

Query: 369 LPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVN 428
           LPTYGYT T SSLGLADF KRMTVQEL+ +G   LA T+ T+A AE L AHK AVT+R+ 
Sbjct: 366 LPTYGYTRTYSSLGLADFSKRMTVQELTADGLKGLAPTVVTMAEAEGLDAHKRAVTIRIE 425

Query: 429 ALKE 432
            L +
Sbjct: 426 KLAQ 429


>UniRef50_Q4QN74 Histidinol dehydrogenase n=38 Tax=cellular organisms
           RepID=HISX_HAEI8
          Length = 427

 Score =  602 bits (1552), Expect = e-170,   Method: Composition-based stats.
 Identities = 274/429 (63%), Positives = 330/429 (76%), Gaps = 3/429 (0%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
             TII WN  +  ++R+++MRP     E+I + VN I +NV   GD AL E   KFD   
Sbjct: 1   MQTII-WNHLSETEKRKVIMRPVQQNGENIQQAVNAIRENVAYNGDRALFELCEKFDGVK 59

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
           +  L VSA+EI AAS R+S +L+ A+  A  NIE FH AQ+   +D+E Q GVRCQ VTR
Sbjct: 60  LDKLIVSADEIQAASSRISVKLRNAIEQAKTNIEAFHKAQQNQEIDLEIQEGVRCQVVTR 119

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVF 182
           P++ VGLYIPGGSAPLFSTVLMLA PA IAGCKK+VLCSPPPI+DEILY A LCGV+ ++
Sbjct: 120 PISCVGLYIPGGSAPLFSTVLMLAIPAKIAGCKKIVLCSPPPISDEILYTAHLCGVETIY 179

Query: 183 NVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVI 242
            +GGAQA+ A+A GTESV KVDKIFGPGNAFVTEAKRQV+Q  +  AIDMPAGPSEVLVI
Sbjct: 180 AIGGAQAVFAMAQGTESVAKVDKIFGPGNAFVTEAKRQVAQ--NSTAIDMPAGPSEVLVI 237

Query: 243 ADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL 302
           AD  A P+FVASDLLSQAEHG DSQVIL+     +A+  A A+ERQLA LPRAETAR+AL
Sbjct: 238 ADESADPEFVASDLLSQAEHGADSQVILVATCETLAKETALAIERQLALLPRAETARKAL 297

Query: 303 NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYA 362
           N SR+ + + L Q VEISN+Y PEHLI+QT+NAR+L+  + +AGS+FLG +SPES GDYA
Sbjct: 298 NHSRIFIAESLEQAVEISNEYAPEHLIVQTKNARKLLPYLDNAGSIFLGAYSPESMGDYA 357

Query: 363 SGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNA 422
           SGTNHVLPTYGYT T SSLGLADF KRMTVQEL+ +GF  LA T+E +A AE+L AHK A
Sbjct: 358 SGTNHVLPTYGYTKTYSSLGLADFSKRMTVQELTPKGFKNLAETVEVMAEAEQLAAHKMA 417

Query: 423 VTLRVNALK 431
           V++R+  L 
Sbjct: 418 VSVRLAKLN 426


>UniRef50_Q492K3 Histidinol dehydrogenase n=542 Tax=Proteobacteria RepID=HISX_BLOPB
          Length = 443

 Score =  598 bits (1542), Expect = e-169,   Method: Composition-based stats.
 Identities = 232/427 (54%), Positives = 305/427 (71%)

Query: 7   IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTAL 66
           I WN C+  +Q++LL RP  +    I   V +IL  V   GD AL +++  FD    T L
Sbjct: 10  IYWNDCSKSEQKKLLTRPINNKLNDIYINVKNILTKVYNEGDRALFKFNFDFDNVQTTQL 69

Query: 67  KVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVAS 126
           ++  E I  +   LS+E+KQA+  A+ NI  FH AQ    + VET PGV CQQ+ RP+  
Sbjct: 70  QIPTEIIMNSGRNLSNEIKQAIHTAMTNITRFHQAQCYSEIIVETLPGVYCQQIIRPLNI 129

Query: 127 VGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVFNVGG 186
           VGLY+PGG+APL STV+ML  PA IA CK+V+LCSPPPI D I+Y AQLCG+ +++ +GG
Sbjct: 130 VGLYVPGGTAPLLSTVMMLGVPARIAKCKRVILCSPPPIPDVIIYTAQLCGIDEIYQIGG 189

Query: 187 AQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSG 246
           +Q+IAA+ FGTES+PKVDKIFGPGN +VTEAKRQ++   +GAAIDM AGPSE+L+IAD+ 
Sbjct: 190 SQSIAAMGFGTESIPKVDKIFGPGNIWVTEAKRQINLAPNGAAIDMLAGPSEILIIADNT 249

Query: 247 ATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASR 306
           A P F+A+DLLSQ+EHGPDS  IL+TP + +A +  + + +QL  LPR +  R  L  SR
Sbjct: 250 ANPIFIAADLLSQSEHGPDSHAILITPYSCIAEKTKKELHKQLKILPRNDIVRNVLLNSR 309

Query: 307 LIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTN 366
           +I+T +L +C  ISN Y PEHLIIQ  NA + +  IT+AGS+FLG+WSPE+AGDYASG N
Sbjct: 310 MIITNNLMECFSISNSYAPEHLIIQIENASDYLHYITNAGSIFLGNWSPETAGDYASGPN 369

Query: 367 HVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
           HVLPTYG     S LG+ DFQKRM+VQ+L++ G   L+STI TL   E+L AH+ A+T R
Sbjct: 370 HVLPTYGRAVATSGLGVIDFQKRMSVQQLTQNGLLQLSSTITTLTQIEQLKAHEYAITHR 429

Query: 427 VNALKEQ 433
           +N +KEQ
Sbjct: 430 INYIKEQ 436


>UniRef50_P59398 Histidinol dehydrogenase n=5 Tax=Buchnera aphidicola
           RepID=HISX_BUCBP
          Length = 435

 Score =  589 bits (1519), Expect = e-167,   Method: Composition-based stats.
 Identities = 215/430 (50%), Positives = 305/430 (70%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
           +  II W SC+ +++R++L RP ++ +  I   V +I+ NVK  GD+AL +Y+  FDK  
Sbjct: 4   YIPIIYWKSCSEKEKREILFRPVVNDNSQIKEVVKEIITNVKNSGDKALYDYTKTFDKIR 63

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
           + +++VS  EI  +   +++E++++++VA  NI+ FH  Q    V++E QPGV C+Q+ R
Sbjct: 64  LESIQVSYGEIVDSDSFVNEEIQKSISVAKNNIKIFHEKQTHNVVNIEIQPGVFCRQIIR 123

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVF 182
           P+ SVGLYIPGG APL STVLMLA PA I GCK ++LCSPPPI  EILYA+++CG+ ++F
Sbjct: 124 PIQSVGLYIPGGCAPLVSTVLMLAIPAKIVGCKNIILCSPPPITKEILYASKICGIHNIF 183

Query: 183 NVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVI 242
            VGGAQAIAA+AFGT+++PKV+KIFGPGN +VTEAK Q++  L+  +IDM AGPSE+L+I
Sbjct: 184 QVGGAQAIAAMAFGTKTIPKVNKIFGPGNVYVTEAKLQINALLNDLSIDMLAGPSEILII 243

Query: 243 ADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL 302
           AD  A    +ASD LSQ EHG  SQ IL+TP+ D+A  V   +  QL  L R +   ++L
Sbjct: 244 ADFKANACIIASDFLSQMEHGIYSQAILVTPSYDLACNVIFEINIQLKNLSRKKVINKSL 303

Query: 303 NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYA 362
             SR+IVTK L +C EISN Y PEHLIIQ  N+  L+  + +AGS+FLG WS  ++GDY 
Sbjct: 304 KYSRIIVTKTLLECFEISNLYAPEHLIIQCENSNRLLVYVINAGSIFLGRWSAVASGDYV 363

Query: 363 SGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNA 422
           +GTNHVLPTYG     S L + DFQK ++VQ+L ++G   ++S+I +L+  ER+ AH N+
Sbjct: 364 TGTNHVLPTYGSAIVNSGLTVMDFQKIISVQKLDQQGLIDVSSSIISLSEVERMDAHTNS 423

Query: 423 VTLRVNALKE 432
           +  R+ AL++
Sbjct: 424 IKQRLIALQD 433


>UniRef50_D1PYE8 Histidinol dehydrogenase n=2 Tax=Prevotella RepID=D1PYE8_9BACT
          Length = 444

 Score =  585 bits (1510), Expect = e-166,   Method: Composition-based stats.
 Identities = 212/432 (49%), Positives = 287/432 (66%), Gaps = 9/432 (2%)

Query: 6   IIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA 65
           II +   +  +  ++L RP +  S  +  TVN+IL +VK+RGDEA+R Y A FD+  +  
Sbjct: 3   IIKYPPKS--EWSRILKRPHLDVS-QLNETVNEILSDVKSRGDEAVRHYEALFDQADLGD 59

Query: 66  LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVA 125
           L VS EEI  A   +S +LK+A+ +A  NI  FH +Q      VET  GV C Q +  + 
Sbjct: 60  LTVSDEEIDEAMSMVSTDLKEALELAYHNISKFHESQLFHGKMVETAQGVVCWQKSVAIE 119

Query: 126 SVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQDV 181
            VGLYIPGG+APLFSTVLMLATPA IAGCK +VLC+PP     I   IL AA + GV  +
Sbjct: 120 KVGLYIPGGTAPLFSTVLMLATPAKIAGCKDIVLCTPPNHDGKIHPAILVAAHIAGVDRI 179

Query: 182 FNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLV 241
           F  GG QAI A+A+GT+++PKV KIFGPGN +V  AK+QVS  L   AIDMPAGPSEV V
Sbjct: 180 FKAGGVQAIGAMAYGTQTIPKVYKIFGPGNQYVMAAKQQVS--LHDVAIDMPAGPSEVCV 237

Query: 242 IADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQA 301
           IAD G+  +FVA+DLLSQAEHG DSQV+L++ + ++   V   VERQL  LPR E A  A
Sbjct: 238 IADEGSNAEFVAADLLSQAEHGSDSQVMLISTSDNLITEVRSQVERQLENLPRREIASDA 297

Query: 302 LNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDY 361
           L  S+ ++  D+ + + +SN+Y PEHLI+ T N  E+ D + +AGSVF+G WS ESAGDY
Sbjct: 298 LKNSKFVLVHDMDEAMRLSNEYAPEHLILSTGNFEEMADKVVNAGSVFMGKWSCESAGDY 357

Query: 362 ASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKN 421
           ASGTNH LPT+ Y    S + L  + +++T Q+LS+ G S++ + +  +A  E L AH +
Sbjct: 358 ASGTNHTLPTHQYALAYSGVNLDSYCRKITFQQLSENGVSSIGNAVVRMAEDEGLEAHAH 417

Query: 422 AVTLRVNALKEQ 433
           A+ +R+  + ++
Sbjct: 418 AMRIRLKKVDDK 429


>UniRef50_P62456 Histidinol dehydrogenase n=127 Tax=Bacteria RepID=HISX_BACC1
          Length = 429

 Score =  583 bits (1505), Expect = e-165,   Method: Composition-based stats.
 Identities = 169/417 (40%), Positives = 250/417 (59%), Gaps = 7/417 (1%)

Query: 17  QRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAA 76
           + +LL   A    E++ R V++I+ NV+  GDEAL  Y+ KFD   +   +VS EE   A
Sbjct: 14  KIKLLRENANIIEETVQRNVSEIVRNVRESGDEALSFYTKKFDGVKIKEFRVSEEEEKRA 73

Query: 77  SERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSA 136
           S  + +   +A+  A KNI ++H  QK   +      G+   Q+ RP+ +VG+Y+PGG+A
Sbjct: 74  SMFVENSFLEALQEAKKNIISYHEKQKRQSMFDCASEGIIRGQIIRPLENVGVYVPGGTA 133

Query: 137 PLFSTVLMLATPASIAGCKKVVLCSPP---PIADEILYAAQLCGVQDVFNVGGAQAIAAL 193
              S+VLM   PA +AG KK+V+ +PP    I   IL AA L GV +++ +GGAQAIAAL
Sbjct: 134 SYPSSVLMNVLPAKLAGVKKIVMVTPPREGGIDPHILVAASLAGVDEIYTIGGAQAIAAL 193

Query: 194 AFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVA 253
           A+GTES+PKVDKI GPGN +V  AKR+V   ++   IDM AGPSE++VIAD      ++A
Sbjct: 194 AYGTESIPKVDKIVGPGNLYVALAKREVYGIVN---IDMIAGPSEIVVIADETGNAKYIA 250

Query: 254 SDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALN-ASRLIVTKD 312
           +DLLSQAEH   +  I +T   ++A++V + +ERQL  LPR+E AR+++N    + +   
Sbjct: 251 ADLLSQAEHDERATAICITTNIELAKKVEKEIERQLETLPRSEIARESINRNGAIFIVPS 310

Query: 313 LAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTY 372
           + + +++SN+  PEHL +  +     +  +  AGS+FLG ++PE  GDY +G NHVLPT 
Sbjct: 311 IDEALQLSNEIAPEHLELHIKEPMNALAYVKHAGSIFLGPYAPEPLGDYLAGPNHVLPTS 370

Query: 373 GYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNA 429
           G     S L + DF K+ +    ++E    +   I  LA  E L AH  A+ +R   
Sbjct: 371 GTARFFSPLSVDDFVKKSSFLSYTEEALRDVQHHIVELANKEGLHAHARAIQIRFEE 427


>UniRef50_UPI00019859BD PREDICTED: hypothetical protein n=1 Tax=Vitis vinifera
           RepID=UPI00019859BD
          Length = 524

 Score =  577 bits (1489), Expect = e-163,   Method: Composition-based stats.
 Identities = 207/432 (47%), Positives = 272/432 (62%), Gaps = 8/432 (1%)

Query: 7   IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTAL 66
              +  +  +   L  RP I  S SI   V+ I+D+V++RGD A+++Y+ +FDK  +  L
Sbjct: 90  YRLSELSQAEVNSLKARPRIDFS-SIFNVVHPIVDDVRSRGDAAVKDYTTRFDKVELDRL 148

Query: 67  KVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVAS 126
             +  E+      L   +K+A  VA  NI  FH AQK     VE   GV+C++V R +AS
Sbjct: 149 IENVAELPD--PELDAGIKEAFDVAYDNIFAFHAAQKSAEKIVENMKGVKCKRVARSIAS 206

Query: 127 VGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQDVF 182
           VGLY+PGG+A L ST LML+ PA IAGCK VVL +PP     I  E+LY A+  GV  + 
Sbjct: 207 VGLYVPGGTAVLPSTALMLSVPAQIAGCKTVVLATPPSQDGGICKEVLYCAKKAGVTHIL 266

Query: 183 NVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVI 242
             GGAQAIAA+A+GT S PKV+KIFGPGN +VT AK  +       +IDMPAGPSEVLVI
Sbjct: 267 KAGGAQAIAAMAWGTTSCPKVEKIFGPGNQYVTAAKMILQNSEAMVSIDMPAGPSEVLVI 326

Query: 243 ADSGATPDFVASDLLSQAEHGPDSQVILLTPAADM-ARRVAEAVERQLAELPRAETARQA 301
           AD  A P  +A+DLLSQAEHGPDSQV+L+     +  R + E + +Q   LPR E A +A
Sbjct: 327 ADKHANPVHIAADLLSQAEHGPDSQVVLVIAGDGVDLRAIEEEISKQCQSLPRGEFASKA 386

Query: 302 LNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDY 361
           L+ S  +  +++ + +  SN Y PEHLII  ++A +  + I +AGSVFLG W+PES GDY
Sbjct: 387 LSHSFTVFARNMVEAISFSNLYAPEHLIINVKDAEKWENFIENAGSVFLGQWTPESVGDY 446

Query: 362 ASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKN 421
           ASGTNHVLPTYGY      L L  F K MTVQ L++EG   L   +E +A  E L AHK 
Sbjct: 447 ASGTNHVLPTYGYARMYGGLSLDSFLKYMTVQSLTEEGLRKLGPYVEAMAEVEGLEAHKR 506

Query: 422 AVTLRVNALKEQ 433
           AVTLR+  ++ +
Sbjct: 507 AVTLRLQDIEAR 518


>UniRef50_D1IQ57 Histidinol dehydrogenase (Fragment) n=1 Tax=Vitis vinifera
           RepID=D1IQ57_VITVI
          Length = 546

 Score =  576 bits (1486), Expect = e-163,   Method: Composition-based stats.
 Identities = 207/432 (47%), Positives = 272/432 (62%), Gaps = 8/432 (1%)

Query: 7   IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTAL 66
              +  +  +   L  RP I  S SI   V+ I+D+V++RGD A+++Y+ +FDK  +  L
Sbjct: 112 YRLSELSQAEVNSLKARPRIDFS-SIFNVVHPIVDDVRSRGDAAVKDYTTRFDKVELDRL 170

Query: 67  KVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVAS 126
             +  E+      L   +K+A  VA  NI  FH AQK     VE   GV+C++V R +AS
Sbjct: 171 IENVAELPD--PELDAGIKEAFDVAYDNIFAFHAAQKSAEKIVENMKGVKCKRVARSIAS 228

Query: 127 VGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQDVF 182
           VGLY+PGG+A L ST LML+ PA IAGCK VVL +PP     I  E+LY A+  GV  + 
Sbjct: 229 VGLYVPGGTAVLPSTALMLSVPAQIAGCKTVVLATPPSQDGGICKEVLYCAKKAGVTHIL 288

Query: 183 NVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVI 242
             GGAQAIAA+A+GT S PKV+KIFGPGN +VT AK  +       +IDMPAGPSEVLVI
Sbjct: 289 KAGGAQAIAAMAWGTTSCPKVEKIFGPGNQYVTAAKMILQNSEAMVSIDMPAGPSEVLVI 348

Query: 243 ADSGATPDFVASDLLSQAEHGPDSQVILLTPAADM-ARRVAEAVERQLAELPRAETARQA 301
           AD  A P  +A+DLLSQAEHGPDSQV+L+     +  R + E + +Q   LPR E A +A
Sbjct: 349 ADKHANPVHIAADLLSQAEHGPDSQVVLVIAGDGVDLRAIEEEISKQCQSLPRGEFASKA 408

Query: 302 LNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDY 361
           L+ S  +  +++ + +  SN Y PEHLII  ++A +  + I +AGSVFLG W+PES GDY
Sbjct: 409 LSHSFTVFARNMVEAISFSNLYAPEHLIINVKDAEKWENFIENAGSVFLGQWTPESVGDY 468

Query: 362 ASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKN 421
           ASGTNHVLPTYGY      L L  F K MTVQ L++EG   L   +E +A  E L AHK 
Sbjct: 469 ASGTNHVLPTYGYARMYGGLSLDSFLKYMTVQSLTEEGLRKLGPYVEAMAEVEGLEAHKR 528

Query: 422 AVTLRVNALKEQ 433
           AVTLR+  ++ +
Sbjct: 529 AVTLRLQDIEAR 540


>UniRef50_O26327 Histidinol dehydrogenase n=6 Tax=Euryarchaeota RepID=HISX_METTH
          Length = 426

 Score =  574 bits (1480), Expect = e-162,   Method: Composition-based stats.
 Identities = 181/428 (42%), Positives = 257/428 (60%), Gaps = 9/428 (2%)

Query: 6   IIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA 65
           ++        +  +L+ R  +   + +   V DI+  V+  GD+ALRE + +FD  TV  
Sbjct: 2   LMKITEFDYRRISELVERARLDV-DDVLGPVADIISMVRDGGDDALRELTGRFDGVTVEN 60

Query: 66  LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVA 125
            +VS EEI  A + L   +K+A+  A  NIE FH  Q       E +PGV   Q+ RP+ 
Sbjct: 61  FRVSREEIEEAHKNLEPGVKEALREAASNIEEFHRMQMPSGWMSEVRPGVMAGQLVRPID 120

Query: 126 SVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQDV 181
           SVG YIPGG A   ST+LM   PA IAG +++V C+PP     + D +L AA + G  ++
Sbjct: 121 SVGCYIPGGRAVYPSTILMTVIPARIAGVERIVCCTPPAQDGSVPDAVLVAADMAGASEI 180

Query: 182 FNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLV 241
           + VGGAQA+AA+A+GTE++  VDKI GPGN FVT AK+ V   +D   ID PAGPSEVL+
Sbjct: 181 YRVGGAQAVAAMAYGTETIRPVDKIVGPGNIFVTAAKKLVYGEVD---IDFPAGPSEVLI 237

Query: 242 IADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQA 301
           IAD  A+P+++A ++L+QAEH P +  +L+T + D+A  V E V   +  + RA   R++
Sbjct: 238 IADETASPEYIALEILAQAEHDPQAASVLVTDSRDLALEVKEMVHENIKYMERANIIRES 297

Query: 302 LN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGD 360
           L     +++T D+ + V+ SN Y PEHL+I T +  E ++ I +AGS+FLG+ SP +AGD
Sbjct: 298 LERYGMIVLTADIDEAVDFSNAYAPEHLVIMTDSPEETLEGIRNAGSIFLGELSPVAAGD 357

Query: 361 YASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHK 420
           Y SGTNHVLPT G     S L    F K+ TVQ ++KEG   L  T+  LA  E L AH 
Sbjct: 358 YGSGTNHVLPTSGCARMYSGLSTESFIKKPTVQRITKEGLRNLQGTVLKLAEYEGLHAHA 417

Query: 421 NAVTLRVN 428
            +   R+ 
Sbjct: 418 ESFRRRLR 425


>UniRef50_Q8R882 Histidinol dehydrogenase n=7 Tax=Clostridia RepID=HISX_THETN
          Length = 430

 Score =  573 bits (1477), Expect = e-162,   Method: Composition-based stats.
 Identities = 179/405 (44%), Positives = 261/405 (64%), Gaps = 10/405 (2%)

Query: 29  SESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA--LKVSAEEIAAASERLSDELKQ 86
           ++ I + V DI++NV+ R D+AL EY+  +D   + +  +KV  EEI  A E + ++  +
Sbjct: 27  NKEIAKRVEDIIENVRERKDKALFEYTYMYDGINLNSETVKVKEEEIKRAYEEVKEDFLK 86

Query: 87  AMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLA 146
           A+  A+KNI  FH  QK     ++ + G+   QV RP++SVG+Y+PGG+A   S+VLM  
Sbjct: 87  ALDKAIKNITEFHEKQKEKTW-MDFKEGIVYGQVLRPLSSVGIYVPGGTASYPSSVLMNG 145

Query: 147 TPASIAGCKKVVLCSPPP---IADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKV 203
            PA +AG +++V+ SP     I+  +L AA   G+++++ +GGAQA+AALAFGTES+PKV
Sbjct: 146 IPAKVAGVERIVMVSPAGKKGISPYVLVAADKIGIKEIYKIGGAQAVAALAFGTESIPKV 205

Query: 204 DKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHG 263
           DKI GPGN +V  AKR +   +D   IDM AGPSE+LVIAD  A+P +VA+DLLSQAEH 
Sbjct: 206 DKIVGPGNIYVAMAKRALYGYVD---IDMVAGPSEILVIADESASPKYVAADLLSQAEHD 262

Query: 264 PDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNA-SRLIVTKDLAQCVEISNQ 322
             +  IL+T + ++A +V + +ERQ+  L R E   ++L     +IV  +L + + I+N+
Sbjct: 263 VMASSILVTTSKELAEKVKKEIERQMEYLERKEIIAESLKNFGAIIVIDNLKEAIGIANE 322

Query: 323 YGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLG 382
             PEHL +   N  E++  I +AG+VFLG++SPE  GDY +G NHVLPT G     S L 
Sbjct: 323 IAPEHLELVIENPFEILGEIKNAGAVFLGEFSPEPLGDYLAGPNHVLPTSGTARFFSPLS 382

Query: 383 LADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRV 427
           + DF K+M V   SKE  S++   + TLA AE LTAH N+V +R 
Sbjct: 383 VRDFVKKMNVLYYSKEALSSVKDDVITLAEAEELTAHANSVKVRF 427


>UniRef50_Q39YP7 Histidinol dehydrogenase n=54 Tax=Bacteria RepID=HISX_GEOMG
          Length = 436

 Score =  570 bits (1471), Expect = e-161,   Method: Composition-based stats.
 Identities = 172/434 (39%), Positives = 251/434 (57%), Gaps = 10/434 (2%)

Query: 7   IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT---V 63
           +D      + +   ++         + + V DI+ +V+ARGDEAL EY+ +FD+     V
Sbjct: 4   LDIRDTNFDMEFAAILARGEETGREVEQVVLDIIADVRARGDEALLEYTRRFDRLEADSV 63

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRP 123
            +L+V+ +E+  A  R+ DE   A+ +AV+ +  FH  QK        +P +   Q+  P
Sbjct: 64  ASLQVTEDEVDYAFARVKDEEIAALKLAVERVARFHEKQKQETWLSTGEPDILLGQMVTP 123

Query: 124 VASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCGVQD 180
           +  VG+Y+PGG A   S+V+M A PA +AG  +VV+ +P P   I   +L AA+  GV  
Sbjct: 124 LERVGIYVPGGKASYPSSVIMNAVPARVAGVGEVVMVAPTPGGEINPHVLVAARFSGVDR 183

Query: 181 VFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVL 240
           +F +GGAQA+AALA+GT +VPKVDKI GPGN +V  AK+ V  ++    IDM AGPSE+L
Sbjct: 184 IFRLGGAQAVAALAYGTATVPKVDKITGPGNIYVATAKKLVFGQV---GIDMIAGPSEIL 240

Query: 241 VIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQ 300
           VI D   TP  +A+DLLSQAEH   +  IL+T       RVA  VERQLAEL R   AR+
Sbjct: 241 VINDGSGTPAHIAADLLSQAEHDELASSILITTDRGFGERVAAEVERQLAELSRETIARR 300

Query: 301 ALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAG 359
           +      +IV   L + +  SN+  PEHL +   N  +++  I +AG++FLG ++PE+AG
Sbjct: 301 SWETYGAVIVAGSLDEAIAFSNRIAPEHLELAVTNPFDVLPKIRNAGAIFLGHFTPEAAG 360

Query: 360 DYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAH 419
           DY +G NH LPT G     S L + DF K+ ++   S+ G + L   I  +A  E L AH
Sbjct: 361 DYLAGPNHTLPTGGTARFFSPLSVDDFVKKSSIVYFSESGLNRLGGGIVRIAELEGLEAH 420

Query: 420 KNAVTLRVNALKEQ 433
             +V++R+    E 
Sbjct: 421 GRSVSVRLKGEGEA 434


>UniRef50_Q9C5U8 Histidinol dehydrogenase, chloroplastic n=34 Tax=cellular organisms
           RepID=HISX_ARATH
          Length = 466

 Score =  570 bits (1469), Expect = e-161,   Method: Composition-based stats.
 Identities = 209/432 (48%), Positives = 274/432 (63%), Gaps = 8/432 (1%)

Query: 7   IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTAL 66
              +  ++ Q   L  RP I  S SI  TVN I+D V++ GD A++EY+ +FDK  +  +
Sbjct: 35  YRLSELSSSQVDSLKSRPRIDFS-SIFATVNPIIDAVRSNGDNAVKEYTERFDKVQLNKV 93

Query: 67  KVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVAS 126
                E+  +   L   +K+A  VA  NI  FH AQK     VE   GVRC++V+R + S
Sbjct: 94  VEDMSEL--SVPELDSNVKEAFDVAYDNIYAFHLAQKSTEKSVENMKGVRCKRVSRSIGS 151

Query: 127 VGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQDVF 182
           VGLY+PGG+A L ST LMLA PA IAGCK VVL +PP     I  E+LY A+  GV  + 
Sbjct: 152 VGLYVPGGTAVLPSTALMLAIPAQIAGCKTVVLATPPSKDGSICKEVLYCAKRAGVTHIL 211

Query: 183 NVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVI 242
             GGAQAIAA+A+GT+S PKV+KIFGPGN +VT AK  +       +IDMPAGPSEVLVI
Sbjct: 212 KAGGAQAIAAMAWGTDSCPKVEKIFGPGNQYVTAAKMILQNSEAMVSIDMPAGPSEVLVI 271

Query: 243 ADSGATPDFVASDLLSQAEHGPDSQVILLTPAADM-ARRVAEAVERQLAELPRAETARQA 301
           AD  A+P ++A+DLLSQAEHGPDSQV+L+     +    + E + +Q   LPR E A +A
Sbjct: 272 ADEHASPVYIAADLLSQAEHGPDSQVVLVVVGDSVDLNAIEEEIAKQCKSLPRGEFASKA 331

Query: 302 LNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDY 361
           L+ S  +  +D+ + +  SN Y PEHLII  ++A +    I +AGSVF+G W+PES GDY
Sbjct: 332 LSHSFTVFARDMIEAISFSNLYAPEHLIINVKDAEKWEGLIENAGSVFIGPWTPESVGDY 391

Query: 362 ASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKN 421
           ASGTNHVLPTYGY    S + L  F K MTVQ L++EG   L   + T+A  E L AHK 
Sbjct: 392 ASGTNHVLPTYGYARMYSGVSLDSFLKFMTVQSLTEEGLRNLGPYVATMAEIEGLDAHKR 451

Query: 422 AVTLRVNALKEQ 433
           AVTLR+  ++ +
Sbjct: 452 AVTLRLKDIEAK 463


>UniRef50_Q58851 Histidinol dehydrogenase n=16 Tax=Euryarchaeota RepID=HISX_METJA
          Length = 429

 Score =  569 bits (1467), Expect = e-161,   Method: Composition-based stats.
 Identities = 174/405 (42%), Positives = 241/405 (59%), Gaps = 11/405 (2%)

Query: 30  ESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAMA 89
           E I  TV +IL +VK +GDEAL+ Y+ KFD   +   KV+ EEI  A   +  ++ +A+ 
Sbjct: 30  EEILPTVMEILKDVKEKGDEALKYYTKKFDGVEIEDFKVTDEEIEEAYNSVDYKVVEAIE 89

Query: 90  VAVKNIETFHTAQKL--PPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLAT 147
            A +NI  FH  Q      ++VE   G+   QV R +  VG Y+PGG A   STVLM   
Sbjct: 90  RAKENIYFFHKKQMEQIKDLNVENN-GIILGQVVRAIEKVGCYVPGGRAFYPSTVLMTTI 148

Query: 148 PASIAGCKKVVLCSPPPI----ADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKV 203
           PA +AGC+++ + SPP          L A  + GV  ++ VGG QAI ALA+GTE++PKV
Sbjct: 149 PAKVAGCEEIYITSPPTKDGKGNPATLIAGDIVGVSAIYKVGGVQAIGALAYGTETIPKV 208

Query: 204 DKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHG 263
           D I GPGN +VT AK+ V   +   AID  AGPSEVL+IAD  A  +FVA D ++QAEH 
Sbjct: 209 DIIVGPGNIYVTTAKKMVYGEV---AIDFLAGPSEVLIIADETANAEFVALDFIAQAEHD 265

Query: 264 PDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQCVEISNQY 323
           P++  ++ T +   A  +   +  ++ +  R E   +AL  S +++  DL +C+E SN+Y
Sbjct: 266 PNASCVITTTSEKKAEEIKNKIFEEIEKAERKEIILKALENSAILI-GDLEECIEFSNKY 324

Query: 324 GPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGL 383
            PEHL I T+N  E+++ I  AGSVFLG++SP   GDYASGTNHVLPT  +    S L +
Sbjct: 325 APEHLEILTKNPEEVLNKIKHAGSVFLGEYSPVPVGDYASGTNHVLPTSQFARMSSGLNV 384

Query: 384 ADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVN 428
             F K++T Q+L KE    +A  + TLA AE L  H  AV  R+ 
Sbjct: 385 ETFLKKITYQKLDKESLKNIADIVITLAEAEGLFGHAEAVRRRLK 429


>UniRef50_Q02136 Histidinol dehydrogenase n=9 Tax=Bacteria RepID=HISX_LACLA
          Length = 431

 Score =  568 bits (1464), Expect = e-160,   Method: Composition-based stats.
 Identities = 166/431 (38%), Positives = 251/431 (58%), Gaps = 11/431 (2%)

Query: 7   IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV--T 64
           ID+     E   +   R     S+ + +TV  I+ +++  GD AL  Y+ KFD   V  +
Sbjct: 5   IDYQGKLEEIAEKFQGR-KTEVSKEVNKTVQQIVADIQKNGDTALFNYAKKFDGYDVNTS 63

Query: 65  ALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPV 124
            L V+  E  A  E++ ++  + +      IE FH  Q     ++  + GV   Q+ RP+
Sbjct: 64  NLLVTRMEREAGLEQIDEDYFRILRRTKSQIEEFHKHQLGNSWNIFKENGVIMGQIARPL 123

Query: 125 ASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSP----PPIADEILYAAQLCGVQD 180
             V LY+PGG+A   STV+M A PA +AG K++++ +P      +   IL AA++CG++ 
Sbjct: 124 ERVALYVPGGTAAYPSTVIMNAVPALLAGVKEIIMITPVKADGKVNPNILAAAEVCGIET 183

Query: 181 VFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVL 240
           ++ VGGAQ +AA+A+GTES+PKVDKI GPGN FV  AK+     +D   IDM AGPSEVL
Sbjct: 184 IYKVGGAQGVAAVAYGTESIPKVDKIVGPGNIFVATAKKICYGVVD---IDMIAGPSEVL 240

Query: 241 VIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQ 300
           VIAD  A P ++A+DL++QAEH   +  IL+T +  + ++V E + RQ+  L R E    
Sbjct: 241 VIADKTAKPKYIAADLMAQAEHDKLASAILVTTSEKLVQQVDEELNRQVQNLERREIIES 300

Query: 301 AL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAG 359
           ++ N    IV K++    ++SNQ  PEHL + T      +  I +AGS+F+G+++PE  G
Sbjct: 301 SIRNYGGAIVVKNIDDAFDVSNQLAPEHLEVLTSEPLTQLPKIKNAGSIFIGEYTPEPLG 360

Query: 360 DYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAH 419
           DY SG+NHVLPT G     S LG+ +F K +T     KE  +     +ET A +E LTAH
Sbjct: 361 DYMSGSNHVLPTGGTAKFYSGLGVYNFIKYLTYSYYPKEVLADFKEDVETFAKSEGLTAH 420

Query: 420 KNAVTLRVNAL 430
            N++++R + +
Sbjct: 421 ANSISVRFDEM 431


>UniRef50_Q722Y3 Histidinol dehydrogenase n=20 Tax=Firmicutes RepID=HISX_LISMF
          Length = 427

 Score =  567 bits (1463), Expect = e-160,   Method: Composition-based stats.
 Identities = 171/419 (40%), Positives = 246/419 (58%), Gaps = 7/419 (1%)

Query: 15  EQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIA 74
           E   +L +    + S  +   V  I++ VK  GD+AL ++++KFD   +T L+V A +I 
Sbjct: 10  ELLNELKIETDTNTSIQVETEVKTIIEKVKTAGDQALFDFTSKFDGVGLTELRVPAADIQ 69

Query: 75  AASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGG 134
           AAS ++      A+  A  NIE+FH+ QK        + GV   Q+ RP+ +VG+Y+PGG
Sbjct: 70  AASAKIEPAFLDALQQAKVNIESFHSKQKQHAFLDSEKDGVIRGQLIRPLETVGVYVPGG 129

Query: 135 SAPLFSTVLMLATPASIAGCKKVVLCSPP---PIADEILYAAQLCGVQDVFNVGGAQAIA 191
           +A   S+VLM   PA IAG K++V+ +PP    I   +L +AQL GV +++ VGGA  IA
Sbjct: 130 TAAYPSSVLMNVLPAKIAGVKRIVMITPPGENGINPYVLASAQLAGVDEIYQVGGAHGIA 189

Query: 192 ALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDF 251
           ALA GTES+PKVDKI GPGN +V  AKR+V   +D   IDM AGPSE++V+AD  A P F
Sbjct: 190 ALAHGTESIPKVDKIVGPGNIYVATAKREVFGLVD---IDMIAGPSEIVVLADENANPAF 246

Query: 252 VASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALN-ASRLIVT 310
           +A+DLLSQAEH   ++ IL+T +  +A      +++QL  LPR   A++++    ++I+ 
Sbjct: 247 IAADLLSQAEHDILARAILITTSKKIAEETQNEIDKQLENLPRKAIAQKSIETRGKIIIA 306

Query: 311 KDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLP 370
               +  +I N+  PEHL +Q  N    +  I +AGS+FLG ++ E  GDY +G NHVLP
Sbjct: 307 ATTQEMFDIMNEIAPEHLEVQLENPMNYLYQIKNAGSIFLGSYASEPLGDYFAGPNHVLP 366

Query: 371 TYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNA 429
           T G     S LG+ DF KR      +KE  +     I  LA  E L AH  A+ +R   
Sbjct: 367 TSGTAKFFSPLGVEDFTKRSAFISYTKEALAKEKDAIVLLAKKEGLDAHAKAIQIRFEE 425


>UniRef50_A8RCE7 Putative uncharacterized protein n=1 Tax=Eubacterium dolichum DSM
           3991 RepID=A8RCE7_9FIRM
          Length = 427

 Score =  565 bits (1458), Expect = e-160,   Method: Composition-based stats.
 Identities = 180/425 (42%), Positives = 255/425 (60%), Gaps = 11/425 (2%)

Query: 10  NSCTAEQQRQL---LMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTAL 66
                EQ  QL   +    +  + ++   V+ IL++V+  GDEA+  Y+ +FD   +  L
Sbjct: 3   KQLNIEQIDQLQSYIEERRVVMNPALIGRVSAILEDVRMHGDEAVLRYTKQFDGMELNKL 62

Query: 67  KVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVAS 126
           +VS+EE+ A ++  + E +++M  A +NI  +H AQ      +E + G+   Q   P+ S
Sbjct: 63  RVSSEELNAQADLCTPEFRRSMQQAKENILFYHQAQISKGYRLEKEMGIYLGQRVLPLDS 122

Query: 127 VGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQDVF 182
           VG+Y+PGGSA   S+VLM A PA +AG K++V+ +PP     I   I  AA+L G+ +V+
Sbjct: 123 VGIYVPGGSAQYPSSVLMNALPARLAGVKRIVMLTPPSKEGSIHTNIALAAKLVGIDEVY 182

Query: 183 NVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVI 242
            VGGAQ IAALA+GT+S+ KVDKI GPGN +V  AK+ V   +D   IDM AGPSE+LVI
Sbjct: 183 KVGGAQGIAALAYGTQSIAKVDKIVGPGNVYVACAKKLVFGDVD---IDMIAGPSEILVI 239

Query: 243 ADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL 302
            D GA P ++A+DLLSQAEH P +  +LL  + +M   V + +++Q   LPR +   ++L
Sbjct: 240 GDEGANPKWIAADLLSQAEHDPQASAVLLAVSQNMVDAVKQELQKQTRCLPRQKIIHESL 299

Query: 303 NASRL-IVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDY 361
               L +V + L QCV+ISNQ  PEHL +      EL+  +  AGSVFLG  + ES GDY
Sbjct: 300 ENYGLALVCESLQQCVDISNQIAPEHLELMVDKPEELLPLVRHAGSVFLGYATCESVGDY 359

Query: 362 ASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKN 421
             GTNHVLPT G     + LG+  F K+ +    S E   A   +I TLA AE+L AH N
Sbjct: 360 FGGTNHVLPTGGTARFFNPLGVDSFVKKSSYLHYSIEALQAYGDSIITLAEAEQLQAHAN 419

Query: 422 AVTLR 426
           AV +R
Sbjct: 420 AVKVR 424


>UniRef50_Q465R4 Histidinol dehydrogenase n=7 Tax=Euryarchaeota RepID=HISX_METBF
          Length = 433

 Score =  564 bits (1454), Expect = e-159,   Method: Composition-based stats.
 Identities = 182/434 (41%), Positives = 252/434 (58%), Gaps = 10/434 (2%)

Query: 1   MSFNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDK 60
           M        +  +  + ++LL R   S  E + +TV+ +L +V+ +GD ALREY+AKFDK
Sbjct: 1   MVMMLFKKLSDVSEAEMQKLLSRG--SGLEDVAKTVSTVLSDVRTKGDSALREYTAKFDK 58

Query: 61  TTVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLP-PVDVETQPGVRCQQ 119
             +    VS EE   A   +S EL   +  A  NI  FH AQ       +E +PG+   Q
Sbjct: 59  VELANFGVSEEEFQQALSGISPELLDHLKSAAANIRAFHEAQLPKATWFMELKPGIVLGQ 118

Query: 120 VTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQL 175
              P+ SVG Y PGG A   STVLM   PA +AG ++V++C+PP     +    L AA++
Sbjct: 119 KATPLESVGAYAPGGRASYPSTVLMTVIPARVAGVEQVIVCTPPRPDGSVHPLTLAAAKV 178

Query: 176 CGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAG 235
            G   VF +GG QAI ++A+GTE+VPKVDKI GPGN FVT AK Q+    D A ID PAG
Sbjct: 179 AGADKVFKLGGVQAIGSMAYGTETVPKVDKIVGPGNVFVTAAKMQIR---DVAEIDFPAG 235

Query: 236 PSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRA 295
           PSEVL+IAD  A    VASD+L+Q+EH P+S  IL+T +  +A  V   V  Q  +  R+
Sbjct: 236 PSEVLIIADESADAVMVASDILAQSEHDPNSVSILVTGSDTLAEAVKREVLVQAEQAARS 295

Query: 296 ETARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSP 355
              + +L  + +++   L QC+  SN++ PEHL I   +   ++D I +AGS+F+G++SP
Sbjct: 296 SIIKSSLENAAILIADSLEQCIGFSNKFAPEHLEIMVADPDFVLDRIKNAGSIFIGNYSP 355

Query: 356 ESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAER 415
              GDYASGTNHVLPT GY    S L +  F K  ++Q +SK G  +L  T+  LA  E 
Sbjct: 356 VPVGDYASGTNHVLPTSGYARVYSGLNINHFIKYSSIQRISKSGLESLKETVIALAEEEG 415

Query: 416 LTAHKNAVTLRVNA 429
           L AH +A+  R   
Sbjct: 416 LQAHADAIRTRFGY 429


>UniRef50_D1CF70 Histidinol dehydrogenase n=1 Tax=Thermobaculum terrenum ATCC
           BAA-798 RepID=D1CF70_THET1
          Length = 433

 Score =  563 bits (1453), Expect = e-159,   Method: Composition-based stats.
 Identities = 186/427 (43%), Positives = 272/427 (63%), Gaps = 9/427 (2%)

Query: 7   IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTAL 66
           I     + E++R+L  R   + S  +T  V  I+++V+ +GDE++REY+ +FD   + +L
Sbjct: 10  IRLADLSPEERRRLTHRSG-AISMDVTSVVRQIVEDVRQKGDESVREYTERFDGVKLDSL 68

Query: 67  KVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVAS 126
           +V   EI  A +R+   L +AM++A  NI  FH+AQ  P   VET PGV+  +V RP+  
Sbjct: 69  EVPRVEIETALDRIDQHLAEAMSIAASNIRAFHSAQIHPEPVVETSPGVKVWRVWRPIER 128

Query: 127 VGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQDVF 182
           VG+Y+PGG A   STVLM A PAS+AGC ++VLC+PP     + +  L AA L GV  VF
Sbjct: 129 VGVYVPGGGARYPSTVLMHAVPASVAGCSEIVLCTPPGPDGKVPEATLAAAALSGVTRVF 188

Query: 183 NVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVI 242
           ++GGAQAIAA+A+GT+++P V KIFGPGN +VT AK  V   +D   ID PAGPSE+++I
Sbjct: 189 SIGGAQAIAAMAYGTQTIPPVQKIFGPGNVYVTAAKMLVFGDVD---IDKPAGPSELVII 245

Query: 243 ADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL 302
           AD  A P   A+DL++Q+EH PD+  +L+T +  +A  V   + RQL +LP  +    + 
Sbjct: 246 ADDTADPRETAADLIAQSEHAPDNASVLVTTSESLAEAVLSELTRQLEDLPNRDRVISSF 305

Query: 303 N-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDY 361
                +++ +DLAQ V   N+Y PEHL I T + RE+++ I +AGS+FLG +SP  AGDY
Sbjct: 306 RSNGFILLVEDLAQAVGFVNEYAPEHLQIVTVSPREILEGINNAGSIFLGRYSPVPAGDY 365

Query: 362 ASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKN 421
           A G+NHVLPT G   T   L   +F K + VQEL++EG  ++++ +  +A AE L  H  
Sbjct: 366 AVGSNHVLPTSGSARTFGPLSTEEFGKWVQVQELTQEGLRSISNAVTAMARAENLEGHAR 425

Query: 422 AVTLRVN 428
           A+ +R +
Sbjct: 426 AIEVRFS 432


>UniRef50_C6Y3G2 Histidinol dehydrogenase n=6 Tax=cellular organisms
           RepID=C6Y3G2_PEDHD
          Length = 430

 Score =  563 bits (1451), Expect = e-159,   Method: Composition-based stats.
 Identities = 198/431 (45%), Positives = 277/431 (64%), Gaps = 6/431 (1%)

Query: 5   TIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVT 64
            I  +   T ++  ++ +R  +    +I   V  I++ VK  GD+AL +Y+  FD+  + 
Sbjct: 2   KIYSYKDLTKQEVEEICLR-QLEDDVNIQERVKSIVERVKMEGDKALFDYALSFDQIRLE 60

Query: 65  ALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPV 124
            L +  +EI   +  +  E K A+  A +NI+TFH +Q L    VET PGV C + TR +
Sbjct: 61  ELFIDQQEIMTIAATIPAEAKAAIDTAYQNIKTFHASQLLQEDKVETMPGVTCWRETRAI 120

Query: 125 ASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIAD----EILYAAQLCGVQD 180
             VGLYIPGG+A L ST LML  PA +AGCK++V+CSPP         + Y A L G++ 
Sbjct: 121 ERVGLYIPGGTAVLPSTFLMLGIPAVLAGCKEIVVCSPPQKDGKTNCYLAYVATLLGIER 180

Query: 181 VFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVL 240
           ++ VGGAQA+AA+A+GT SVPKVDK+FGPGN +VT+AK+ +       AIDMPAGPSEVL
Sbjct: 181 IYLVGGAQAVAAMAYGTASVPKVDKVFGPGNRYVTQAKQLIQGNT-MTAIDMPAGPSEVL 239

Query: 241 VIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQ 300
           V+AD  A P ++ASDLL+QAEHG DSQ IL+  ++ +     E +  QL  LPRA  A +
Sbjct: 240 VLADETAIPSYIASDLLAQAEHGIDSQTILVATSSKIIDETMEQLALQLQVLPRAAFATK 299

Query: 301 ALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGD 360
           A+  S  ++  DL + ++ SN Y PEHLI+ T N   L+  I++AGSVFLG+ +PESAGD
Sbjct: 300 AIENSYSVLVNDLEEGMKFSNVYAPEHLILATDNCERLIPLISNAGSVFLGNLTPESAGD 359

Query: 361 YASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHK 420
           YASGTNH LPT GY    S + +  F K++T Q ++ +G   + +T+E LAAAE L AHK
Sbjct: 360 YASGTNHTLPTSGYARAYSGVSMDSFMKKITFQHITTQGLRHIGNTVEVLAAAEGLDAHK 419

Query: 421 NAVTLRVNALK 431
           NAV++R+ +L 
Sbjct: 420 NAVSIRLKSLD 430


>UniRef50_Q30TA4 Histidinol dehydrogenase n=16 Tax=Epsilonproteobacteria
           RepID=HISX_SULDN
          Length = 430

 Score =  561 bits (1447), Expect = e-158,   Method: Composition-based stats.
 Identities = 164/425 (38%), Positives = 249/425 (58%), Gaps = 11/425 (2%)

Query: 10  NSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV---TAL 66
           NS    + ++LL R  +  +  ++ TV  I+D +K+  ++AL+E+  KFDK T      L
Sbjct: 8   NSSFKAEFKELLERGKMDIAH-VSATVGTIIDEIKSNKNQALKEHITKFDKWTPVSDEDL 66

Query: 67  KVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVAS 126
           K+S E ++ A E L   LK A+ ++   I+ +H  QK      +   G    Q   PV S
Sbjct: 67  KISTESMSRAYENLDKALKAALHLSYDRIKAYHEKQKPRSWFDDEPNGTILGQRVTPVDS 126

Query: 127 VGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIAD---EILYAAQLCGVQDVFN 183
            GLYIPGG A   S++LM   PA +AG + +V+C+P P  +    +L A  LCGV +V+ 
Sbjct: 127 AGLYIPGGKAAYPSSLLMNVIPAQVAGVQNIVVCTPTPENEPNELLLAACHLCGVSEVYK 186

Query: 184 VGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIA 243
           VGGA AIAA+A+GTE++PKVD I GPGN FV  AK+ V   ++   IDM AGPSE+ ++A
Sbjct: 187 VGGASAIAAMAYGTETIPKVDVITGPGNIFVATAKKMVFGDVN---IDMIAGPSEIGILA 243

Query: 244 DSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALN 303
           D  A P  +A D+LSQAEH   +  IL+TP+  +A  +   +E  L  LPR + AR+++ 
Sbjct: 244 DDSANPSHMAVDMLSQAEHDEMASSILITPSQKLADAIKAEIENWLKILPRQKIARESIE 303

Query: 304 A-SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYA 362
               +IVT D+ + +++ N+  PEHL + T +  EL+  I  AG++FLG  +PE+ GDY 
Sbjct: 304 KRGAIIVTSDMQEAIDLMNEIAPEHLEVATLSPFELLPLIKHAGAIFLGHNTPEAVGDYM 363

Query: 363 SGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNA 422
           +G NH LPT G     S LG+ +F K+ ++   S +  + +      +A  E LTAH+ +
Sbjct: 364 AGPNHTLPTGGTAKFFSPLGVENFMKKTSIISFSAKAINEIGEECALIAKIEGLTAHEQS 423

Query: 423 VTLRV 427
           + +R+
Sbjct: 424 IRVRL 428


>UniRef50_C0GFZ9 Histidinol dehydrogenase n=1 Tax=Dethiobacter alkaliphilus AHT 1
           RepID=C0GFZ9_9FIRM
          Length = 432

 Score =  561 bits (1446), Expect = e-158,   Method: Composition-based stats.
 Identities = 183/430 (42%), Positives = 244/430 (56%), Gaps = 8/430 (1%)

Query: 10  NSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVS 69
                   R+   R         T+ V DIL  V  RGDEA+ EY+ KFD   +  L VS
Sbjct: 3   REFDGRTFRETFTRAGFDDYPEATQAVRDILAEVNQRGDEAVLEYTRKFDGVELETLLVS 62

Query: 70  AEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGL 129
            EE AAA E +  E++Q++  A +NI  FH  Q           GV   Q    V   G 
Sbjct: 63  EEEFAAAEEAVDPEVRQSLVEAAENIRDFHRRQVQNSWLEHQADGVALGQRVTAVEKAGA 122

Query: 130 YIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQDVFNVG 185
           Y+PGG A   S+VLM   PA +AG +KVVL +PP     I    L AA++ G   V+  G
Sbjct: 123 YVPGGGAAYPSSVLMTVIPARVAGVEKVVLVTPPQAGGEINPYTLVAAKIAGADAVYKCG 182

Query: 186 GAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADS 245
           GAQA+AALA+GTE+VPKVDKI GPGN +VT AKR+VS  +    IDM AGPSEVLV+AD+
Sbjct: 183 GAQAVAALAYGTETVPKVDKIVGPGNLYVTLAKREVSGMV---GIDMLAGPSEVLVVADA 239

Query: 246 GATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NA 304
            A  DFVA+DLLSQAEH   +    +T +A +A  + + ++RQ A+L R + AR++L   
Sbjct: 240 SARADFVAADLLSQAEHDVMAASYCVTTSARLALDLQKELKRQCAQLERCDVARESLQQQ 299

Query: 305 SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASG 364
             L++   L + +EI N+  PEHL +Q     E +  + +AG+VF+G ++PE  GDY +G
Sbjct: 300 GALVIVDSLDEALEIVNELAPEHLELQLSEPWEALGKVKNAGAVFVGPYTPEPVGDYWAG 359

Query: 365 TNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVT 424
            NHVLPT G     S L + DF K+ +V   S +     A  IE LA  E LTAH  AV 
Sbjct: 360 PNHVLPTAGAGRFSSVLSVDDFVKKTSVIYYSPQALLKSAQKIEGLARVEGLTAHGQAVK 419

Query: 425 LRVNALKEQA 434
           +R   L+E+ 
Sbjct: 420 IRREYLEEKG 429


>UniRef50_Q46J19 Histidinol dehydrogenase n=60 Tax=Bacteria RepID=HISX_PROMT
          Length = 449

 Score =  560 bits (1444), Expect = e-158,   Method: Composition-based stats.
 Identities = 165/433 (38%), Positives = 252/433 (58%), Gaps = 10/433 (2%)

Query: 4   NTIIDWNSCTAEQ--QRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKT 61
            TI   NS    Q   R++  R + +  +   + V+DIL NV+ RGDEAL EY+++FD  
Sbjct: 18  LTIKTANSIDQAQFELRKITERTSGTVQDEAIKVVDDILKNVRERGDEALTEYTSRFDGF 77

Query: 62  TVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVT 121
                +VS++ I  A E    EL+ ++ +A K IE FH+ Q    +      G    +  
Sbjct: 78  LTEKFQVSSDLILKAWEETPRELQDSLLLAKKRIEKFHSLQVPKNITYTGPNGETLGRRW 137

Query: 122 RPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCG 177
            PV   G+Y+PGG A   STVLM A PA +AG  ++++ SP      I   +L AA + G
Sbjct: 138 SPVEKAGIYVPGGRAAYPSTVLMNAIPAYVAGVNQIIMVSPANSQGEINQTVLAAAHITG 197

Query: 178 VQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPS 237
           +  +F +GGAQAI ALA GTES+PKVD I GPGN +VT AK++V  ++    ID  AGPS
Sbjct: 198 INKIFRLGGAQAICALASGTESIPKVDVITGPGNIYVTLAKKKVYGKV---GIDSLAGPS 254

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAET 297
           E+L+IAD  A  + VASD+L+Q+EH P +  IL+T    +A ++   + RQL   PR + 
Sbjct: 255 EILIIADQSAKLEHVASDMLAQSEHDPLASAILITTNTKLAEKLPAEINRQLINHPRLKI 314

Query: 298 ARQAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPE 356
            ++++ N   +++  DL  C ++S+ + PEHL +   + ++L +SI +AG++F+G WSPE
Sbjct: 315 CQESISNWGLIVLCDDLETCAQLSDTFAPEHLELLVEDPKKLSESINNAGAIFMGPWSPE 374

Query: 357 SAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERL 416
           + GDY  G NH LPT G      +LG+  F K  ++ + SKE F+   + +  LA +E L
Sbjct: 375 AIGDYLGGPNHTLPTSGTARFAGALGVETFMKNTSLIDFSKEAFNENKNAVVQLANSEGL 434

Query: 417 TAHKNAVTLRVNA 429
            +H  ++ +R + 
Sbjct: 435 HSHAESIRIRDSK 447


>UniRef50_B0TY46 Histidinol dehydrogenase n=2 Tax=Francisella philomiragia
           RepID=B0TY46_FRAP2
          Length = 432

 Score =  559 bits (1441), Expect = e-158,   Method: Composition-based stats.
 Identities = 191/432 (44%), Positives = 276/432 (63%), Gaps = 4/432 (0%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              I +W   +  +Q +LL RP  +   S+   V +IL+ VK  GD+AL E++++FD   
Sbjct: 1   MIEIYNWQELSLVKQAELLSRPVSANKASLVAGVRNILNAVKQNGDKALLEFTSRFDGVD 60

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
           +  ++VSA EI  A   +S +  + +  ++  I  +H   K      +T  GV C+++ +
Sbjct: 61  LDNIEVSAHEIKEAYSLVSQDDIELVKNSIARISNYHEVMKPKTTVCDTNDGVVCKKIYK 120

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSP----PPIADEILYAAQLCGV 178
           P+  VGLY+PGGSAPL ST++MLA PA IAGCK++ + +P      I   IL AA +C V
Sbjct: 121 PIEKVGLYVPGGSAPLVSTLIMLAAPAQIAGCKEIYVTTPCDKEGNIHPLILIAADICKV 180

Query: 179 QDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSE 238
             ++ +GGAQAIAALA+GTE+V KV+KI+GPGN++VTEAK+QVS    GAAID+PAGPSE
Sbjct: 181 SKIYKLGGAQAIAALAYGTETVTKVNKIYGPGNSWVTEAKQQVSNDSQGAAIDLPAGPSE 240

Query: 239 VLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETA 298
           VLV+AD  A   FVA+DLL+QAEHG DSQ +L+T +  +A +V + V +Q +   R    
Sbjct: 241 VLVVADEVADARFVAADLLAQAEHGTDSQALLITTSQILADKVRDEVSKQTSTAQRKAII 300

Query: 299 RQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESA 358
            +AL  S +IV   L+Q + I+N+Y  EHLI+    A   +DSI +AG+VF+G W+ E+ 
Sbjct: 301 EKALENSAIIVVDTLSQAINIANEYASEHLILNIETADNYIDSIENAGAVFVGPWAAEAL 360

Query: 359 GDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTA 418
           GDY +G+NHVLPTYGY    S L   DF K +++Q +SK+G   +      LA  E L A
Sbjct: 361 GDYITGSNHVLPTYGYAKAYSGLATIDFMKAISIQNVSKQGIKNIGQIAMRLADIEGLKA 420

Query: 419 HKNAVTLRVNAL 430
           H+NA+ +R+ +L
Sbjct: 421 HENAIAIRLESL 432


>UniRef50_A9NV24 Histidinol dehydrogenase n=2 Tax=Spermatophyta RepID=A9NV24_PICSI
          Length = 491

 Score =  554 bits (1428), Expect = e-156,   Method: Composition-based stats.
 Identities = 197/440 (44%), Positives = 265/440 (60%), Gaps = 15/440 (3%)

Query: 7   IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTAL 66
                  + Q   L  RP I  S S+   V  I+++V+ RGD A+ +Y+ KFD   +  +
Sbjct: 53  YRLADLHSTQIDHLKARPRIDFS-SMFGVVGPIIEDVRKRGDVAVIDYTTKFDGVNLDKV 111

Query: 67  KVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQP-------GVRCQQ 119
                ++     +L   ++ A  VA  NI  FH AQ+ P   VE          GV C++
Sbjct: 112 VECVADLPD--PKLDSAVQAAFDVAYDNIRAFHAAQRNPERVVENMKVGSVLGRGVMCKR 169

Query: 120 VTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQL 175
           V R + SVGLY+PGG+A L ST LMLA PA +AGC+ ++L SPP     I  E+LY A+ 
Sbjct: 170 VARSIDSVGLYVPGGTAVLPSTALMLAVPAQLAGCRIIILASPPRPDGSICKEVLYCAKK 229

Query: 176 CGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAG 235
            GV  +   GGAQAI+A+A+GT S PKV+KI GPGN +VT AK  +       +IDMPAG
Sbjct: 230 AGVTHILKAGGAQAISAMAWGTTSCPKVEKILGPGNQYVTAAKMILQNSEAMISIDMPAG 289

Query: 236 PSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADM-ARRVAEAVERQLAELPR 294
           PSEVLVIAD  A P ++A+DLLSQAEHGPDSQV+L+     +    +   +E+Q   LPR
Sbjct: 290 PSEVLVIADKHANPVYIAADLLSQAEHGPDSQVVLVLVGEGVNLDEIEMELEKQCKSLPR 349

Query: 295 AETARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWS 354
            + A +AL  S  ++ ++ A+ +  SN Y PEHLII   +A + VD I +AGSVFLG WS
Sbjct: 350 GQFAAKALTHSFTVLARNKAEAISFSNLYAPEHLIINVEDADQWVDYIENAGSVFLGRWS 409

Query: 355 PESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAE 414
           PES GDYASGTNHVLPTYGY      + L  F K +TVQ L++EG  +L   +  +A  E
Sbjct: 410 PESIGDYASGTNHVLPTYGYARMYGGVSLDSFMKYITVQSLTEEGLKSLGPHVVKMAEVE 469

Query: 415 RLTAHKNAVTLRVNALKEQA 434
            L AHK AVTLR+  ++ ++
Sbjct: 470 GLEAHKRAVTLRLQDIETRS 489


>UniRef50_D0JBA3 Histidinol dehydrogenase n=2 Tax=Blattabacterium RepID=D0JBA3_BLASB
          Length = 435

 Score =  554 bits (1428), Expect = e-156,   Method: Composition-based stats.
 Identities = 185/430 (43%), Positives = 270/430 (62%), Gaps = 7/430 (1%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
           N I  +   T +  + +L R +   S  +T  V  I++NVK  GD A++ Y+ K+D   +
Sbjct: 3   NMIQVYIHPTYKTCQSILNRSSEKISH-LTDLVLSIINNVKNNGDTAVKTYTRKYDHVDI 61

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRP 123
             ++V+ E+   A+ ++S  L++++ +A KNIE FH  Q      +E   GV C + + P
Sbjct: 62  KHIQVTEEDFQKANMKVSSHLRKSIEIAYKNIECFHKKQIHEESKIEVSTGVFCWRKSVP 121

Query: 124 VASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQ 179
           +  VG YIPGGSAPL STVLML  P  +AGCK +VLCSPP     I   +LY A+  G+ 
Sbjct: 122 IEKVGFYIPGGSAPLLSTVLMLGVPGKLAGCKNIVLCSPPNKNGEIHPSVLYTAKYVGIN 181

Query: 180 DVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEV 239
            ++ VGG QAIAA+A+GTES+P V KIFGPGN +VT AK+ VSQ+    +IDMPAGPSEV
Sbjct: 182 QIYKVGGVQAIAAMAYGTESIPSVYKIFGPGNCYVTIAKQIVSQK-GIVSIDMPAGPSEV 240

Query: 240 LVIADSGATPDFVASDLLSQAEHGPDSQVILLT-PAADMARRVAEAVERQLAELPRAETA 298
           +++AD  A P +VASDLLSQ+EH P+S ++L+T        +V E +++Q   L + +  
Sbjct: 241 VIMADDEANPKYVASDLLSQSEHDPESYILLVTINNKSWIEKVKEELKKQFYHLSKKKIL 300

Query: 299 RQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESA 358
            +    S+++V   L +C+   NQ  PEHLII   N     + + +AGSVFLG++SP S 
Sbjct: 301 LKIFRKSKIVVFSSLEECMNFINQVAPEHLIINCNNVSYWSEKVINAGSVFLGNYSPVSI 360

Query: 359 GDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTA 418
           GDYASGTNHVLPTYGY  + S + +  F K++T Q++SK+G   L+  +  L++ E L A
Sbjct: 361 GDYASGTNHVLPTYGYAKSYSGVSVDSFVKKITFQKISKKGLQNLSECVNVLSSEEGLIA 420

Query: 419 HKNAVTLRVN 428
           HK ++ +R+ 
Sbjct: 421 HKKSIDIRLK 430


>UniRef50_Q4ZNV9 Histidinol dehydrogenase n=116 Tax=Bacteria RepID=HISX_PSEU2
          Length = 448

 Score =  553 bits (1426), Expect = e-156,   Method: Composition-based stats.
 Identities = 167/422 (39%), Positives = 240/422 (56%), Gaps = 11/422 (2%)

Query: 13  TAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDK---TTVTALKVS 69
            A     LL   ++S  +S+ + V DI+  V+ RGD AL E++ KFD     ++  L + 
Sbjct: 17  FARHLDHLLSWESVS-DDSVNQRVLDIIKAVRERGDAALVEFTQKFDGLQVASMADLILP 75

Query: 70  AEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGL 129
            E +  A  R++   ++A+  A + + ++H  QK          G    Q   P+   GL
Sbjct: 76  RERLELALTRITPGQREALEKAAERVRSYHEKQKQDSWSYTEADGTVLGQKVTPLDRAGL 135

Query: 130 YIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCGVQDVFNVGG 186
           Y+PGG A   S+VLM A PA +AG  +VV+  P P   I + +L AA + GV  VF +GG
Sbjct: 136 YVPGGKASYPSSVLMNAIPAKVAGVTEVVMVVPTPRGEINELVLAAACIAGVDRVFTIGG 195

Query: 187 AQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSG 246
           AQA+AALA+GTESVPKVDK+ GPGN +V  AKR V  ++    IDM AGPSE+LV+ D  
Sbjct: 196 AQAVAALAYGTESVPKVDKVVGPGNIYVATAKRHVFGQV---GIDMIAGPSEILVVCDGQ 252

Query: 247 ATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNA-S 305
             PD++A DL SQAEH  D+Q IL++P A+   +VA ++ R L  + RA     ++N   
Sbjct: 253 TDPDWIAMDLFSQAEHDEDAQAILVSPDAEFLDKVAASITRLLPTMERAAIVETSINGRG 312

Query: 306 RLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGT 365
            LI   D+AQ +E++N+  PEHL +   +    +  I  AG++F+G  + E+ GDY +G 
Sbjct: 313 ALIKVADMAQAIEVANRIAPEHLELSVADPEAWLPQIRHAGAIFMGRHTSEALGDYCAGP 372

Query: 366 NHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTL 425
           NHVLPT G     S LG+ DFQKR ++   S +G S L  T   LA  E L+ H  +   
Sbjct: 373 NHVLPTSGTARFSSPLGVYDFQKRSSIIYCSPQGASELGKTASVLARGESLSGHARSAEY 432

Query: 426 RV 427
           R+
Sbjct: 433 RI 434


>UniRef50_Q2NHT1 HisD n=1 Tax=Methanosphaera stadtmanae DSM 3091 RepID=Q2NHT1_METST
          Length = 407

 Score =  553 bits (1425), Expect = e-156,   Method: Composition-based stats.
 Identities = 164/409 (40%), Positives = 252/409 (61%), Gaps = 8/409 (1%)

Query: 28  ASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQA 87
            S  + + V +I+ NV    D+AL +Y+ KFDK  ++  KV  E I  + E +S +L++A
Sbjct: 2   NSSDVIQPVQEIIANVCENKDKALHDYTLKFDKADISDFKVPVETIKQSVENISPKLRKA 61

Query: 88  MAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLAT 147
           +  A +NI  FH AQ      +  + GV+  Q+ RP++ VG YIPGG A   S++LM   
Sbjct: 62  LEDAAENISKFHKAQIPSDWTMTVKDGVKAGQIIRPLSRVGCYIPGGRAAYPSSILMTVI 121

Query: 148 PASIAGCKKVVLCSPPP----IADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKV 203
           PA IAG ++++ C+PP     ++DEIL AA + GV D++ VGGAQAIAA+A+ T+++P V
Sbjct: 122 PAKIAGVEEIICCTPPDKDGCVSDEILAAAYIAGVTDIYMVGGAQAIAAMAYSTQTIPSV 181

Query: 204 DKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHG 263
           DKI GPGN FV  AK+ V   +D   I+ PAGPSE+L + D  A P+++A++LL+QAEH 
Sbjct: 182 DKIVGPGNIFVATAKKLVYGDVD---IEFPAGPSEMLALVDETANPEYIATELLAQAEHD 238

Query: 264 PDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVEISNQ 322
           P++  IL++ + ++A++  E V   L    R++   ++L     ++V   +   ++ +N 
Sbjct: 239 PNAATILVSTSKEVAQKTVEHVMEYLKTQKRSDIIEESLSKYGHVLVASSMEDAIDFTNA 298

Query: 323 YGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLG 382
           Y PEHL+I T++  + ++SI +AGS+FLG+ +P + GDY SGTNHVLPT G     S L 
Sbjct: 299 YAPEHLVIVTKDHYKTLESINNAGSIFLGNLTPVAGGDYGSGTNHVLPTSGGARMYSGLS 358

Query: 383 LADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNALK 431
              F K+ T+QELS EG   +   +  LA AE L AH  ++  R   ++
Sbjct: 359 AESFLKKPTIQELSPEGVKNIKDMVINLAEAEGLYAHALSIKKRAEDME 407


>UniRef50_Q8YSM8 Histidinol dehydrogenase 1 n=16 Tax=Bacteria RepID=HISX1_ANASP
          Length = 431

 Score =  552 bits (1423), Expect = e-156,   Method: Composition-based stats.
 Identities = 174/431 (40%), Positives = 256/431 (59%), Gaps = 7/431 (1%)

Query: 6   IIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA 65
           ++         + Q L+     A+  ++ TV DIL +VKARGD A++EY+++FD     +
Sbjct: 3   VLKTTDKEFSPRFQSLVSDRREATVDVSGTVRDILAHVKARGDAAVQEYTSRFDHYRPHS 62

Query: 66  LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVA 125
             +SA  IA  + + SDE+K A+ +A + I +FH  Q    +      GV+       ++
Sbjct: 63  HHLSAAFIAEQAAKCSDEVKAALELAAERISSFHQKQLPQDIGYTDTAGVKLGLNWVALS 122

Query: 126 SVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCGVQDVF 182
            VG+Y+PGG A   S+VLM A PA IAG +++V+  P P   I   +L AAQ+ GV +++
Sbjct: 123 QVGIYVPGGRASYPSSVLMNALPAKIAGVERIVMTVPMPHGEINPAVLAAAQVAGVTEIY 182

Query: 183 NVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVI 242
           ++GGAQA+ ALA+GTE++  VDKI GPGNA+V EAKRQV   +    ID  AGPSE+LV+
Sbjct: 183 SIGGAQAVGALAYGTETITPVDKIVGPGNAYVAEAKRQVFGTV---GIDSIAGPSEILVV 239

Query: 243 ADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL 302
           AD    P+++A DLLSQAEH P +Q IL+T +   A++V  AVE+ L  LP  + A  + 
Sbjct: 240 ADRQNNPEWIAWDLLSQAEHDPSAQSILITDSESFAQQVIAAVEQILTTLPSQKVASSSW 299

Query: 303 -NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDY 361
            N   +I+ +DLA+ + + NQ  PEH+ +   N + L   I  AGS+FLG ++PE+ GDY
Sbjct: 300 QNHGAVIIVRDLAESIPLLNQLAPEHVELCVDNPQLLASQIKCAGSLFLGRYTPEAIGDY 359

Query: 362 ASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKN 421
             G NHVLPT       S L + DF KR+T  E ++     +  +  TLA  E L AH  
Sbjct: 360 LGGPNHVLPTSRSARFASGLSVYDFLKRITYLECNQAALQKIGQSAVTLAETEGLPAHAG 419

Query: 422 AVTLRVNALKE 432
           +V +R+  LK+
Sbjct: 420 SVAVRLQGLKD 430


>UniRef50_P59399 Histidinol dehydrogenase n=14 Tax=Bacteria RepID=HISX_LACPL
          Length = 428

 Score =  552 bits (1423), Expect = e-155,   Method: Composition-based stats.
 Identities = 174/419 (41%), Positives = 248/419 (59%), Gaps = 7/419 (1%)

Query: 14  AEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEI 73
           A  +R +  +        +   V +I+ NV   GD A+++Y  +FDK T+T  K+S   I
Sbjct: 9   ASLKRLVQTKTQQLTDLKVESAVREIIANVIKNGDAAVKDYETQFDKVTLTDFKLSQTVI 68

Query: 74  AAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPG 133
             A   L  ++K A+ +A +NI +FH  +K        QPGV   Q   P+  VGLY+PG
Sbjct: 69  DDAYNNLDPQVKDALLLAKRNITSFHEKEKATGFIDAEQPGVLRGQKLMPLNRVGLYVPG 128

Query: 134 GSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCGVQDVFNVGGAQAI 190
           G+A   ST+LM A PA IAG  +V++ +PP    I   +L AA++ GV  ++ VGGAQAI
Sbjct: 129 GTAAYPSTLLMSALPAKIAGVNEVIMVTPPQVDGINPAVLAAAKIAGVDAIYQVGGAQAI 188

Query: 191 AALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPD 250
           AALA+GTES+P VDKI GPGN FV  AK+QV  ++   AIDM AGPSE+ ++AD  A P 
Sbjct: 189 AALAYGTESIPAVDKIIGPGNIFVATAKKQVFGQV---AIDMVAGPSEIGILADDSADPR 245

Query: 251 FVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALN-ASRLIV 309
            +A+DLLSQAEH   ++ IL+T +AD+A+ V++ V  QL  LPR   A  A+N    + V
Sbjct: 246 QLAADLLSQAEHDRRARPILITDSADLAQAVSDNVTSQLKVLPREAIATDAVNEKGFIAV 305

Query: 310 TKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVL 369
              + +  ++ N   PEHL +Q +N  + ++ I +AGSVFLG ++ E  GDY +G NH+L
Sbjct: 306 VAKIEEMFDLMNTVAPEHLEVQLKNPTQYLNLIKNAGSVFLGRYASEPLGDYVAGPNHIL 365

Query: 370 PTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVN 428
           PT G     S LG+ DF KR +  + +K+  +  A  I TLA  E L  H  A+  R +
Sbjct: 366 PTSGTARFSSPLGVYDFVKRTSFIQYTKDALAKEAPAITTLARVEGLEGHARAIESRFD 424


>UniRef50_Q6FEC8 Histidinol dehydrogenase n=50 Tax=Bacteria RepID=HISX_ACIAD
          Length = 430

 Score =  551 bits (1420), Expect = e-155,   Method: Composition-based stats.
 Identities = 163/424 (38%), Positives = 246/424 (58%), Gaps = 10/424 (2%)

Query: 10  NSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKT---TVTAL 66
              + +Q    L+         + +TV+ I+ +V+  GDE + + + +FD+      + L
Sbjct: 8   QDQSFKQVFADLLAFETVNDPELLKTVDQIIADVRQYGDEHVLKLTQQFDRHPAHQFSDL 67

Query: 67  KVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVAS 126
           +++ E++  A E L+ E+++A+ +A + I +FH AQK          G    Q   P+  
Sbjct: 68  ELTQEQLKTAFEALTAEIREALELAAERIRSFHQAQKQEGWSYVDALGNTLGQKVTPLDR 127

Query: 127 VGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCGVQDVFN 183
           VG+Y+PGG A   S+VLM A PA +AG  ++++  P P   +   +L AA L GV  +F 
Sbjct: 128 VGIYVPGGLASYPSSVLMNAIPAHVAGVPEIIMVVPAPNGELNSLVLAAAYLAGVSRIFT 187

Query: 184 VGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIA 243
           +GGAQA+AALA+GT+++P VDKI GPGN FV  AKR V  ++    IDM AGPSE+LV A
Sbjct: 188 IGGAQAVAALAYGTQTIPAVDKITGPGNRFVAAAKRAVFGQV---GIDMIAGPSEILVYA 244

Query: 244 DSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL- 302
           +      ++A DLLSQAEH   +Q I +TP   +   VA+A+E  LA LP+A+ AR ++ 
Sbjct: 245 EGQNNAKWLAMDLLSQAEHDTVAQAIFITPDEALLDEVAQAIEEHLAALPKADIARTSIA 304

Query: 303 NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYA 362
           N   L++ KD  + +E+ NQ  PEHL +    +  +   I  AG++F+G ++PE+ GDY 
Sbjct: 305 NRGALVLVKDRDEAIELINQVAPEHLELCLDESEAMSQKIRHAGAIFMGRYTPEAIGDYC 364

Query: 363 SGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNA 422
           +G NHVLPT G     S LG+ DFQKR ++   S+EG  +LA   + LA  E L AH  +
Sbjct: 365 AGPNHVLPTSGTARFSSPLGVYDFQKRSSLIMCSQEGVKSLAKAADVLAQQENLDAHARS 424

Query: 423 VTLR 426
              R
Sbjct: 425 ARYR 428


>UniRef50_B9D1F9 Histidinol dehydrogenase n=2 Tax=Campylobacter RepID=B9D1F9_WOLRE
          Length = 431

 Score =  551 bits (1420), Expect = e-155,   Method: Composition-based stats.
 Identities = 159/423 (37%), Positives = 243/423 (57%), Gaps = 9/423 (2%)

Query: 15  EQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVT--ALKVSAEE 72
           +     L+  +     ++T  V+ IL++V+ARGDEAL E   KFD+      +LK+  EE
Sbjct: 12  KDYFAALVNRSNGDMSAVTPAVSQILEDVRARGDEALFEQIEKFDRWKPDTNSLKIGTEE 71

Query: 73  IAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIP 132
           +  A + +   L+ A+ +A + I+++H            + GV       P+   GLYIP
Sbjct: 72  MQKAYDGIDSCLRNALNLAFERIKSYHEKSLPKTWMEHDEHGVLLGAKYTPLDRAGLYIP 131

Query: 133 GGSAPLFSTVLMLATPASIAGCKKVVLCSPP---PIADEILYAAQLCGVQDVFNVGGAQA 189
           GG A   S++LM A PA +AG  ++ +C+P     +   +L A  +CG+++ + VGGA A
Sbjct: 132 GGKAAYPSSLLMNAVPALVAGVGEIAVCTPAVGGKVNTLLLAAMHICGIKEAYKVGGASA 191

Query: 190 IAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATP 249
           +AA+A+GT+++ K D I GPGN +V  AK+ V   ++   IDM AGPSE+ VIAD  A P
Sbjct: 192 VAAMAYGTQTIKKTDVITGPGNIYVATAKKLVYGEVN---IDMIAGPSEICVIADESADP 248

Query: 250 DFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNA-SRLI 308
             +A DLLSQAEH   +  +L+TP       V   +  ++  L R   A+ +++    +I
Sbjct: 249 RHIAVDLLSQAEHDEMASAVLITPNQAFGAAVQRHINEEIKTLARQPIAQASIDKKGAII 308

Query: 309 VTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHV 368
           V  DL +CV ++N+  PEHL I T +A EL   I  AG++F+G ++PE+ GDY +G NH 
Sbjct: 309 VASDLGECVRLANELAPEHLEIATNDAMELARQIRHAGAIFIGHFTPEAMGDYLAGPNHT 368

Query: 369 LPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVN 428
           LPT G     S LG+ +F KR ++  L+ +G S LA+    LA AE L AH+ +V +R+ 
Sbjct: 369 LPTGGSARFYSPLGVENFMKRTSLISLNAKGISELANACMELAEAEGLGAHRRSVVVRLE 428

Query: 429 ALK 431
           ALK
Sbjct: 429 ALK 431


>UniRef50_P00815 Histidinol dehydrogenase n=17 Tax=cellular organisms
           RepID=HIS2_YEAST
          Length = 799

 Score =  551 bits (1420), Expect = e-155,   Method: Composition-based stats.
 Identities = 194/430 (45%), Positives = 269/430 (62%), Gaps = 10/430 (2%)

Query: 10  NSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVS 69
            +      ++ L RP    SE I   VN I++NV+ +G+ AL EY+ KFD   ++   ++
Sbjct: 363 KASDKVGVQKALSRPIQKTSE-IMHLVNPIIENVRDKGNSALLEYTEKFDGVKLSNPVLN 421

Query: 70  AEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPV-DVETQPGVRCQQVTRPVASVG 128
           A       E L++E+K+A+ ++++N+  FH AQ      +VETQPGV C +  RP+  VG
Sbjct: 422 APFPEEYFEGLTEEMKEALDLSIENVRKFHAAQLPTETLEVETQPGVLCSRFPRPIEKVG 481

Query: 129 LYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP-----PIADEILYAAQLCGVQDVFN 183
           LYIPGG+A L ST LML  PA +A CK++V  SPP      ++ E++Y A+  G   +  
Sbjct: 482 LYIPGGTAILPSTALMLGVPAQVAQCKEIVFASPPRKSDGKVSPEVVYVAEKVGASKIVL 541

Query: 184 VGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDG-AAIDMPAGPSEVLVI 242
            GGAQA+AA+A+GTE++PKVDKI GPGN FVT AK  V        +IDMPAGPSEVLVI
Sbjct: 542 AGGAQAVAAMAYGTETIPKVDKILGPGNQFVTAAKMYVQNDTQALCSIDMPAGPSEVLVI 601

Query: 243 ADSGATPDFVASDLLSQAEHGPDSQVILLTP--AADMARRVAEAVERQLAELPRAETARQ 300
           AD  A  DFVASDLLSQAEHG DSQVIL+    +    + + +AV  Q  +LPR +  R+
Sbjct: 602 ADEDADVDFVASDLLSQAEHGIDSQVILVGVNLSEKKIQEIQDAVHNQALQLPRVDIVRK 661

Query: 301 ALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGD 360
            +  S +++     + +E+SNQY PEHLI+Q  NA + V  + +AGSVF+G ++PES GD
Sbjct: 662 CIAHSTIVLCDGYEEALEMSNQYAPEHLILQIANANDYVKLVDNAGSVFVGAYTPESCGD 721

Query: 361 YASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHK 420
           Y+SGTNH LPTYGY    S    A FQK +T Q ++ EG   +   +  +A  E L  H+
Sbjct: 722 YSSGTNHTLPTYGYARQYSGANTATFQKFITAQNITPEGLENIGRAVMCVAKKEGLDGHR 781

Query: 421 NAVTLRVNAL 430
           NAV +R++ L
Sbjct: 782 NAVKIRMSKL 791


>UniRef50_C9LTV1 Histidinol dehydrogenase n=1 Tax=Selenomonas sputigena ATCC 35185
           RepID=C9LTV1_9FIRM
          Length = 449

 Score =  550 bits (1418), Expect = e-155,   Method: Composition-based stats.
 Identities = 164/451 (36%), Positives = 247/451 (54%), Gaps = 26/451 (5%)

Query: 5   TIIDWNSCTAEQQRQLLMRP---AISASESITRTVNDI--------------LDNVKARG 47
            I+       ++ R+LL++P    +  +  I      I              +++V+  G
Sbjct: 2   KIVSAKELGKDKIRKLLVKPPFDEVQLNPKIREANRKIFGADLTAAEVAVRIVEDVRRHG 61

Query: 48  DEALREYSAKFDKTT--VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLP 105
           DEA+ +Y+   D T       +VS EE A A +     +  ++  A  N+ ++H  QK  
Sbjct: 62  DEAVIKYTKLIDGTDFSPEDFQVSEEEFAEAEKNADPAIVASLQRAAHNVRSYHEEQKAN 121

Query: 106 PVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP- 164
                 + G    Q   P+   G+Y+PGG+A   S+VLM A PA++AG  ++++  PP  
Sbjct: 122 SWLTYREKGSILGQSLIPLDRAGIYVPGGTAAYPSSVLMNAVPAAVAGVGEIIMMVPPKN 181

Query: 165 --IADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVS 222
             I   +L AA++ GV  V+ +GGAQAIAA+A+GT ++P+VDKI GPGN FVT AK+ V 
Sbjct: 182 GKINPYVLLAAKIAGVSKVYKIGGAQAIAAMAYGTATIPRVDKITGPGNIFVTLAKKAVY 241

Query: 223 QRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVA 282
              D   IDM AGPSE+L++AD  A P + A+D+LSQAEH   +  IL+T +A +A  V 
Sbjct: 242 GHCD---IDMLAGPSEILIVADETADPAYTAADMLSQAEHDTLASSILITTSAKLAHEVE 298

Query: 283 EAVERQLAELPRAETARQALNASR-LIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDS 341
             +E QL  LPR   AR ++  +  +++  D+ + +E +N   PEH+ + T+   EL+  
Sbjct: 299 ALLEEQLKGLPRENIARASIENNGLIVIADDIMEALEYANISAPEHMELLTKQPFELLPY 358

Query: 342 ITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFS 401
           +  AG+VFLG +SPE  GDY +G NHVLPT G     S L +  F KR ++   +K+   
Sbjct: 359 VRHAGAVFLGAYSPEPLGDYFAGPNHVLPTGGTARFYSVLNVETFMKRTSIISYTKDALH 418

Query: 402 ALASTIETLAAAERLTAHKNAVTLRVNALKE 432
            + + I  LA AE L AH NAV LR    K+
Sbjct: 419 DVEADIIRLAEAEGLHAHANAVRLRSKERKD 449


>UniRef50_C0QG33 Histidinol dehydrogenase n=4 Tax=Deltaproteobacteria
           RepID=C0QG33_DESAH
          Length = 432

 Score =  549 bits (1415), Expect = e-155,   Method: Composition-based stats.
 Identities = 177/434 (40%), Positives = 249/434 (57%), Gaps = 13/434 (2%)

Query: 5   TIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFD--KTT 62
            I  + S   EQ+    ++  +  +    R V   +++V+ RGD+AL EY+ +FD  + T
Sbjct: 2   KIYTYPSPEGEQRICDTLKRGLGFTPENQRAVEAYIEDVRTRGDQALVEYTNQFDSSQVT 61

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
              LKVS +EI  A   +  +  +A+  AV  + TFH+ Q+        + GV   Q+  
Sbjct: 62  RDTLKVSQQEIEEAKTLVDSDFSRALDRAVDQLGTFHSRQRQNSWIDTPRNGVMVGQMVN 121

Query: 123 PVASVGLYIPG---GSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQL 175
           PV + G+Y PG   G  PL S+VLM   PA +AG K   L +PP     I   +L AA  
Sbjct: 122 PVDAAGIYAPGAKGGKTPLVSSVLMGGIPARVAGVKSCCLMTPPMENGKINPYMLVAADR 181

Query: 176 CGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAG 235
            G+  +F  G A AIAALAFGTESVPKVD I GPGN FVT AK+ VS  +    IDM AG
Sbjct: 182 VGINAIFKAGSAWAIAALAFGTESVPKVDVIVGPGNIFVTLAKKIVSGIV---GIDMIAG 238

Query: 236 PSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRA 295
           PSE+L+IAD GA PD +A+DLLSQAEH P +  IL+T + +MA R   A+E Q+  L R 
Sbjct: 239 PSEILIIADKGANPDHIAADLLSQAEHDPMASAILVTDSMEMATRTKAALEIQVKALGRR 298

Query: 296 ETARQALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWS 354
           + A+++++    ++   D+   + ++N+  PEHL +   N  + V  I +AG+VFLG ++
Sbjct: 299 QIAQRSIDDFGAIMKVPDIDTAIALANRLAPEHLELIVDNPFDQVGKIKNAGAVFLGPYT 358

Query: 355 PESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAE 414
           PE  GDY +G NHVLPT G     S+LG+ +F KR ++   SKE F   A  +  LA  E
Sbjct: 359 PEPMGDYIAGPNHVLPTAGTARFSSALGVDNFTKRTSLINYSKEAFDREAQDVMVLANIE 418

Query: 415 RLTAHKNAVTLRVN 428
            L AH N+V +R  
Sbjct: 419 GLGAHANSVRIRTK 432


>UniRef50_B2KCM4 Histidinol dehydrogenase n=1 Tax=Elusimicrobium minutum Pei191
           RepID=B2KCM4_ELUMP
          Length = 429

 Score =  548 bits (1414), Expect = e-154,   Method: Composition-based stats.
 Identities = 198/432 (45%), Positives = 280/432 (64%), Gaps = 9/432 (2%)

Query: 5   TIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVT 64
            I ++ + T ++ + L  R  +   E + + V +    V  RGD+A++E +A FD  T++
Sbjct: 2   KIYNYATLTKKEIKALSERSYL-MPEKLKQAVWETGLQVMKRGDKAIKELTAAFDGVTLS 60

Query: 65  ALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQ-KLPPVDVETQPGVRCQQVTRP 123
           +LKVS +E   A + +S+ELK A+  A +NI  FH +Q K     +ET  G+ C +  + 
Sbjct: 61  SLKVSVKEFKQAEKLVSNELKDAIKTASENIAKFHKSQLKTKEPVIETSKGIECWREFKA 120

Query: 124 VASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQ 179
           + + GLY+PGGSAPLFSTVLMLA PA IAGCKKV +C+PP     IA EIL+AA+  GV 
Sbjct: 121 LGTAGLYVPGGSAPLFSTVLMLAVPAKIAGCKKVYICTPPCKNGLIAPEILFAAKTAGVD 180

Query: 180 DVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEV 239
           +V+ +GGAQA+ A+A+GT++VPK DKIFGPGN +VT+AK +VS      AIDMPAGPSEV
Sbjct: 181 EVYKIGGAQAVFAMAYGTQTVPKADKIFGPGNQYVTQAKMEVSS---FTAIDMPAGPSEV 237

Query: 240 LVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETAR 299
           L+IA+      + A+D+LSQAEHGPDSQ +L   + +  + +   V+ QL +L R   A 
Sbjct: 238 LIIAEESTNASYAAADILSQAEHGPDSQAVLACSSKNKIKEIIAEVDAQLKKLGRKSIAA 297

Query: 300 QALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAG 359
           +AL  S ++ T++  + VE SN Y PEHLI+  ++ ++ + S+ +AGSVF G  + ES G
Sbjct: 298 KALGKSFIMQTRNTKESVEFSNIYAPEHLILNFKDWKKYLTSVQNAGSVFCGTLATESFG 357

Query: 360 DYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAH 419
           DYASGTNH LPT G+  +   L    F K +T Q +S +G   L  T+E +A AE LTAH
Sbjct: 358 DYASGTNHTLPTSGFAKSFGGLNTQSFGKWITYQTVSAQGLRGLGKTVEIMAEAEGLTAH 417

Query: 420 KNAVTLRVNALK 431
           KNAVT+R+   K
Sbjct: 418 KNAVTIRIENEK 429


>UniRef50_Q1Q2D0 Histidinol dehydrogenase n=1 Tax=Candidatus Kuenenia
           stuttgartiensis RepID=Q1Q2D0_9BACT
          Length = 439

 Score =  545 bits (1404), Expect = e-153,   Method: Composition-based stats.
 Identities = 164/415 (39%), Positives = 256/415 (61%), Gaps = 11/415 (2%)

Query: 26  ISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA--LKVSAEEIAAASERLSDE 83
           +++S  I  TV  I+ +VK  GD+A+  Y  +FDK  ++    +V  EEI  A + ++ +
Sbjct: 25  LNSSSDIRTTVLKIIQDVKKNGDKAIAAYGKRFDKAPLSPEQFRVKEEEIEDAYKYVTGK 84

Query: 84  LKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVL 143
             +A+ +A+KNI+T+    ++  V      GV    +  P+ S G+Y+PGG+A   STVL
Sbjct: 85  FIKAIRLAIKNIQTYQNHIRIQNVKPLRSKGVILDTIYTPIDSAGIYVPGGAASYPSTVL 144

Query: 144 MLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQDVFNVGGAQAIAALAFGTES 199
           M A PA +AG +K+V+ SPP     I  E L AA+  GV +++ +GG QAIAALAFGT++
Sbjct: 145 MNAIPAQVAGVEKIVMVSPPKEDGNIPPERLVAAKEAGVSEIYKIGGVQAIAALAFGTKT 204

Query: 200 VPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQ 259
           +P VDKI GPGN FVT AK+++      A IDM AGPSEVL+IAD+ A P ++ASDLLSQ
Sbjct: 205 IPSVDKIVGPGNVFVTLAKKEIFGY---AGIDMLAGPSEVLIIADNHANPSYIASDLLSQ 261

Query: 260 AEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVE 318
           AEH P    +L+T +  +A++V   +  Q+  L R+    + L     + +TK++ +C+ 
Sbjct: 262 AEHTPG-ISLLVTSSKLLAKQVLAEITLQIKTLSRSAGTNECLCKYGVIFITKNMNECIA 320

Query: 319 ISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATC 378
           +SN   PEHL I T+N + ++  I  AG+VF+GD++P + GDY +G +HVLPT G     
Sbjct: 321 LSNAIAPEHLQIMTQNPKAVLSGIKHAGAVFVGDYTPVALGDYIAGPSHVLPTGGTARFS 380

Query: 379 SSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNALKEQ 433
           S L + DF KR +V   S+    ++   +  ++A+E L AH  +V +R+++ +++
Sbjct: 381 SGLSVNDFIKRTSVITYSQSALRSVQQDVSEISASEGLDAHAKSVKIRLDSGRKK 435


>UniRef50_D0RRH1 Histidinol dehydrogenase n=1 Tax=alpha proteobacterium HIMB114
           RepID=D0RRH1_9RICK
          Length = 429

 Score =  545 bits (1404), Expect = e-153,   Method: Composition-based stats.
 Identities = 158/430 (36%), Positives = 244/430 (56%), Gaps = 9/430 (2%)

Query: 5   TIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVT 64
            I++  +   ++   L++      S +  + V  I+ ++K  GD AL +Y+ +FDK    
Sbjct: 2   KILNTKNKLFKKNFDLVLSSKRIQSNNSQKIVKKIISDIKKNGDLALIKYTKRFDKVNFG 61

Query: 65  ALKVSAEEIAAASERL--SDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
             K+  ++   + +       +K+++ +A   I  FH  Q       + + G +      
Sbjct: 62  PSKIKLDDKLISKKIKKLDINIKKSIDLAFNRITKFHKKQVHKGFKFKDKLGNQLGYKIL 121

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCGVQ 179
           P+  VG+Y+PGG+A   ST+LM + PA +AG K +    P P   I   +LYAA+ C ++
Sbjct: 122 PLDKVGVYVPGGTASYPSTLLMNSIPAMVAGVKNIYCVMPTPKDEINAGVLYAAKKCKIK 181

Query: 180 DVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEV 239
            +F +GGAQA+AAL +GT++VPKVDKI GPGN FV  AK++V   +    IDM AGPSE+
Sbjct: 182 SIFRIGGAQAVAALTYGTKNVPKVDKIVGPGNIFVATAKKEVFGTV---GIDMVAGPSEI 238

Query: 240 LVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETAR 299
            VIAD     D+ A DLLSQAEH   SQ ILLT +   A++V+  V++ L  LPR + A 
Sbjct: 239 TVIADDRNRADWTAVDLLSQAEHDVLSQSILLTTSEKFAKQVSLEVKKILKTLPRKKIAS 298

Query: 300 QAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESA 358
           +++ N   ++V K+  + V+ +N   PEHL I+ + + +L   I +AGS+FLG++SPE+ 
Sbjct: 299 KSIKNYGCIVVCKNKKELVDYANIIAPEHLEIKIKGSEKLEKQIKNAGSIFLGEFSPEAI 358

Query: 359 GDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTA 418
           GDY +G NHVLPT G     S L + DF KR ++ + +K G   +      LA  E L A
Sbjct: 359 GDYLAGPNHVLPTSGSARFASGLSVNDFLKRTSLIKCTKRGIEKIGQMAINLANYEGLHA 418

Query: 419 HKNAVTLRVN 428
           H  +V+ R+ 
Sbjct: 419 HALSVSKRIK 428


>UniRef50_C9KKX1 Histidinol dehydrogenase n=1 Tax=Mitsuokella multacida DSM 20544
           RepID=C9KKX1_9FIRM
          Length = 447

 Score =  544 bits (1402), Expect = e-153,   Method: Composition-based stats.
 Identities = 157/402 (39%), Positives = 236/402 (58%), Gaps = 9/402 (2%)

Query: 34  RTVNDILDNVKARGDEALREYSAKFDKTT--VTALKVSAEEIAAASERLSDELKQAMAVA 91
             V  I+ +V+  GD A+  Y+   D+         V+  E  AA +     + +++  A
Sbjct: 48  ELVRQIVGDVRREGDAAVIRYTHLIDRVDYKPEDFLVTEAEYEAAEKAADPAVVESLRKA 107

Query: 92  VKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASI 151
            +N+  +H  QK        + G    Q   P+  VG+Y+PGG+A   S+V+M A PAS+
Sbjct: 108 AENVRRYHQEQKPNSWMTYREKGSILGQSIIPLDRVGIYVPGGTAAYPSSVIMNAVPASV 167

Query: 152 AGCKKVVLCSPPP---IADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFG 208
           AG  ++++  PP    I   +L AA+  GV+ ++ +GGAQAIAA+AFGTE++P+VDKI G
Sbjct: 168 AGVGEIIMMVPPKNGKINPYVLIAARAAGVKKIYKIGGAQAIAAMAFGTETIPRVDKITG 227

Query: 209 PGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQV 268
           PGN FVT AK++V   +D   IDM AGPSE+L++AD  A P + A+D+LSQAEH P +  
Sbjct: 228 PGNIFVTLAKKEVYGHVD---IDMLAGPSEILIVADKTADPVYTAADMLSQAEHDPLASS 284

Query: 269 ILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVT-KDLAQCVEISNQYGPEH 327
           I++T  A++A +VA+  E+QLA LPR E A+ +++ + LIV   D+ Q +  +N   PEH
Sbjct: 285 IVITDDAELAEKVAKEAEKQLAALPRREIAQASIDRNGLIVVADDMMQAMRFANVSAPEH 344

Query: 328 LIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQ 387
           + + T    +L+  +  AG+VFLG +SPE  GDY +G NHVLPT G     S L +  F 
Sbjct: 345 MELLTAQPFQLLPYVRHAGAVFLGAYSPEPLGDYFAGPNHVLPTGGTARYYSVLNVETFM 404

Query: 388 KRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNA 429
           KR ++   ++   S ++  I  LA  E L AH NA+ +R   
Sbjct: 405 KRTSIISYTQPALSDVSEDIIRLAETEGLQAHANAIRIRREQ 446


>UniRef50_C4V2I6 Histidinol dehydrogenase n=1 Tax=Selenomonas flueggei ATCC 43531
           RepID=C4V2I6_9FIRM
          Length = 448

 Score =  541 bits (1395), Expect = e-152,   Method: Composition-based stats.
 Identities = 162/403 (40%), Positives = 244/403 (60%), Gaps = 9/403 (2%)

Query: 34  RTVNDILDNVKARGDEALREYSAKFDKTTVTA--LKVSAEEIAAASERLSDELKQAMAVA 91
             V+ I+ +V++ GD+AL  Y+   D   +++  + VS  E+ AA+++    +  ++  A
Sbjct: 48  ELVHHIVRDVRSGGDQALLRYTKLLDGLDLSSTDIMVSESELQAAADQADAAVLASLERA 107

Query: 92  VKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASI 151
            KNI  FH  QK          G    Q   P++ VG+Y+PGG+A   S+VLM A PA +
Sbjct: 108 AKNIFAFHEEQKPKSWMTYRAHGSILGQEVIPLSRVGIYVPGGTAAYPSSVLMNAIPAIV 167

Query: 152 AGCKKVVLCSPPP---IADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFG 208
           AG   +++  P     +   +L AA + G++ +F VGGAQAIAA+A+GTES+P+VDKI G
Sbjct: 168 AGVDDIIMSVPTKGGVLNPYVLAAAHMLGIKKIFRVGGAQAIAAMAYGTESIPRVDKITG 227

Query: 209 PGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQV 268
           PGN FVT AK++V   +D   IDM AGPSE+L++AD  A+P ++A+D+LSQAEH P +  
Sbjct: 228 PGNLFVTLAKKEVYGYVD---IDMLAGPSEILILADEEASPKYIAADMLSQAEHDPLASS 284

Query: 269 ILLTPAADMARRVAEAVERQLAELPRAETARQALN-ASRLIVTKDLAQCVEISNQYGPEH 327
           IL+T +AD+A  V   ++ QL  LPR ETA  +L    R+IVT+++ Q V ++N  GPEH
Sbjct: 285 ILITDSADLASNVRCEIQDQLQSLPRMETASASLERNGRIIVTENIQQSVHLANYSGPEH 344

Query: 328 LIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQ 387
           + +  ++A  L+  I  AG+VF+G +SPE  GDY +G NHVLPT G     S L +  F 
Sbjct: 345 IELLVKDAFHLLPEIRCAGAVFVGSYSPEPLGDYFAGPNHVLPTGGTARFYSVLNVETFM 404

Query: 388 KRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNAL 430
           KR ++   +++    ++  I  LA  E L AH  A+  R + +
Sbjct: 405 KRTSIISYTRKALDEVSDDIIRLAETEGLEAHARAIRTRRDNI 447


>UniRef50_Q2PPB3 Histidine biosynthesis trifunctional protein n=12 Tax=Phaeosphaeria
           RepID=Q2PPB3_PHANO
          Length = 881

 Score =  541 bits (1395), Expect = e-152,   Method: Composition-based stats.
 Identities = 199/423 (47%), Positives = 265/423 (62%), Gaps = 8/423 (1%)

Query: 13  TAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEE 72
           T+E     L RP+  ++  I      I+D VK RGD AL EY+ KF+K T     V    
Sbjct: 456 TSETIAAALQRPSQKSTGKIIGICRPIIDAVKTRGDAALLEYTHKFEKATSLTSPVLRAP 515

Query: 73  IAAASERLSDELKQAMAVAVKNIETFHTAQKL-PPVDVETQPGVRCQQVTRPVASVGLYI 131
                 +L+ E  +A+ V+ +NI  FH AQ+   P+ VET PGV C +  RP+  VGLY+
Sbjct: 516 FPPELMQLAPETAKAIDVSFENIRKFHAAQREEKPLVVETMPGVVCSRFARPIERVGLYV 575

Query: 132 PGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQDVFNVGGA 187
           PGG+A L ST LML  PA +AGCKK+VL +PP     +  E++YAA   G + +   GGA
Sbjct: 576 PGGTAVLPSTALMLGVPAMVAGCKKIVLATPPRSNGKVTPEVVYAAHKVGAEMIVLAGGA 635

Query: 188 QAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLD-GAAIDMPAGPSEVLVIADSG 246
           QA+AA+A+GTESV KVDKI GPGN FVT AK  VS   + G +IDMPAGPSE+LVIAD+ 
Sbjct: 636 QAVAAMAYGTESVSKVDKILGPGNQFVTAAKMHVSNDTNAGVSIDMPAGPSELLVIADAS 695

Query: 247 ATPDFVASDLLSQAEHGPDSQVILLTP--AADMARRVAEAVERQLAELPRAETARQALNA 304
           A P FVASDLLSQAEHG DSQVIL+           + + + +Q   LPR +  R A+  
Sbjct: 696 ANPAFVASDLLSQAEHGVDSQVILIAVGLNEAQLTAIEDELHKQANALPRVDIVRGAIEH 755

Query: 305 SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASG 364
           S  +    + + +E+SNQY PEHLI+Q  NA ++V+ + +AGSVF+G+W+PES GDY++G
Sbjct: 756 SLTLAASTIEEALELSNQYAPEHLILQVANADKVVELVENAGSVFIGEWTPESVGDYSAG 815

Query: 365 TNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVT 424
            NH LPTYGY    S + LA + K +T   L+KEG   +   +  LA  E L AH+ AV+
Sbjct: 816 VNHSLPTYGYAKQYSGVNLASYVKHITSAHLTKEGLQNVGPAVMELARVEELEAHRRAVS 875

Query: 425 LRV 427
           LR+
Sbjct: 876 LRL 878


>UniRef50_B3WED5 Histidinol dehydrogenase n=21 Tax=Bacilli RepID=B3WED5_LACCB
          Length = 430

 Score =  541 bits (1394), Expect = e-152,   Method: Composition-based stats.
 Identities = 177/426 (41%), Positives = 248/426 (58%), Gaps = 7/426 (1%)

Query: 11  SCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSA 70
           + +  +Q+  + R A++ +  +   V  I+  V+A GD ALR YS K D  TV   +V  
Sbjct: 7   TLSQLKQQVDIRRTAVAQNTDVQTIVQAIIAKVRAEGDSALRTYSNKLDHVTVNDFQVDQ 66

Query: 71  EEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLY 130
             I AA  +L  +L +A+ +A  NI ++H  +           G+   Q   P+A+VGLY
Sbjct: 67  ALIDAAPAQLPAKLLKALQLAKANITSYHQNEIERGFVDTPNSGIIRGQKITPLAAVGLY 126

Query: 131 IPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCGVQDVFNVGGA 187
           +PGG+A   ST+LM A PA +AG KK+V+ +PP    +   +L AA L GV  ++ VGGA
Sbjct: 127 VPGGTAAYPSTILMTAIPAKLAGVKKIVMVTPPQPDGLNPVVLAAANLAGVDAIYQVGGA 186

Query: 188 QAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGA 247
           QAIAALA+GTES+P+VDKI GPGN +V EAK+QV   +   AIDM AGPSE+ +IAD  A
Sbjct: 187 QAIAALAYGTESIPRVDKIMGPGNRYVAEAKKQVFGNV---AIDMIAGPSEIGIIADESA 243

Query: 248 TPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNA-SR 306
            P  +A+DLLSQAEH P+++ +++T +  +A  V+E ++ QL  LPR   AR A+     
Sbjct: 244 DPIRLAADLLSQAEHDPNARAMMVTTSEKLASAVSEQIDIQLPTLPRESIARAAIENQGF 303

Query: 307 LIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTN 366
           + +   +     + N   PEHL +Q  +    +  I +AGSVFLG  + E  GDY +G N
Sbjct: 304 IAIVATINDAFSLMNTIAPEHLEVQLPDPITYLAQIQNAGSVFLGQNAAEPVGDYVAGPN 363

Query: 367 HVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
           HVLPT G     S LG+ DF KR    + S E  ++ A  I TLA AE L  H  A+  R
Sbjct: 364 HVLPTAGSARFFSPLGVYDFVKRTQFIQYSSEALASQADAIVTLAQAEGLDGHAEAIIKR 423

Query: 427 VNALKE 432
           V A KE
Sbjct: 424 VPAAKE 429


>UniRef50_Q5FS83 Histidinol dehydrogenase n=3 Tax=Bacteria RepID=HISX_GLUOX
          Length = 430

 Score =  541 bits (1394), Expect = e-152,   Method: Composition-based stats.
 Identities = 177/429 (41%), Positives = 252/429 (58%), Gaps = 9/429 (2%)

Query: 7   IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV--T 64
           +D ++    +    L+    S   S+   V  IL +V++RGDEAL +Y+A+FD+ T+   
Sbjct: 4   LDTSAAGFSEDFATLLAARGSDERSVAEPVRAILADVRSRGDEALCDYTARFDRLTLPAE 63

Query: 65  ALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPV 124
            L++SAEEIA+ + R+  +L  A+  A + IETFH AQ    +D   + G+R      P+
Sbjct: 64  KLRISAEEIASEAARVPADLMDALRTAARRIETFHAAQMPKDLDFTDEDGIRLGMRWTPL 123

Query: 125 ASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCGVQDV 181
            +VGLY+PGG A   S+VLM A PA +AG K++ +C P P   +   +L AAQLCGV+++
Sbjct: 124 DAVGLYVPGGKAAYPSSVLMNALPARVAGVKRLAMCVPSPDGVLNPLVLAAAQLCGVEEI 183

Query: 182 FNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLV 241
           + +GGAQA+ A+AFGT+ +  VD+I GPGNA+V EAKRQV   +    ID  AGPSEV+V
Sbjct: 184 YRIGGAQAVGAMAFGTDLIAPVDRIVGPGNAYVAEAKRQVFGHV---GIDSIAGPSEVVV 240

Query: 242 IADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQA 301
           +AD    P  VA DLL+QAEH   +Q IL+T  A  A R AEAV ++L  LPR   A ++
Sbjct: 241 VADGQNDPRLVALDLLAQAEHDEQAQAILITTDAAFAERAAEAVRKELETLPRTAIASKS 300

Query: 302 L-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGD 360
             +   +IV + L +  EI N   PEHL +     R+    I  AG++F+G + PE+ GD
Sbjct: 301 WEDHGAIIVVRSLEEAAEIVNALAPEHLEVMLDAPRDFSAMIRHAGAIFMGRYCPEAVGD 360

Query: 361 YASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHK 420
           Y  G NHVLPT       S L + DF KR T  E  + G   +      LA AE L AH 
Sbjct: 361 YVGGPNHVLPTSRTARFASGLSVFDFIKRTTTIEADEAGLRRIGPAGVALAKAEGLDAHA 420

Query: 421 NAVTLRVNA 429
            ++++R+  
Sbjct: 421 LSLSVRLEK 429


>UniRef50_Q5ZW87 Histidinol dehydrogenase n=6 Tax=Legionella RepID=HISX_LEGPH
          Length = 431

 Score =  540 bits (1392), Expect = e-152,   Method: Composition-based stats.
 Identities = 191/435 (43%), Positives = 277/435 (63%), Gaps = 9/435 (2%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
             TI +W   +   ++  L RP    S +I   V +I++ V+  GD+AL + + +FD+  
Sbjct: 1   MLTIKNWQLLSENDKKLCLSRPRQ--SSAIKENVLEIINQVQLSGDKALYDLTKQFDRVN 58

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
           +  L+V  E+I  A   +      A+  A+  I ++H +      ++ T  G+  + V R
Sbjct: 59  LQYLQVPQEKIEQA--NIPKNALNAITQAIGTISSYHQSLLPENTEISTASGITIRNVYR 116

Query: 123 PVASVGLYIPGG-SAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCG 177
           P+  VGLY+PGG   PL S++LM A PA +AGC   VLC+PP     I + IL AA+LCG
Sbjct: 117 PIQKVGLYVPGGNKTPLVSSLLMQAIPAKVAGCPIKVLCTPPDAEGEINEHILVAARLCG 176

Query: 178 VQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPS 237
           +  ++ +GGAQAIAA+A+GTESV KVDKIFGPGN++VT+AK  V+   DGAAIDMPAGPS
Sbjct: 177 IDTIYAIGGAQAIAAMAYGTESVIKVDKIFGPGNSYVTQAKTLVAIDADGAAIDMPAGPS 236

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAET 297
           EV+++AD+ A P+F+A+DLL+QAEHGPDSQVIL+    ++A +V + +E Q++ L R E 
Sbjct: 237 EVMILADTEANPEFIAADLLAQAEHGPDSQVILICDECELANQVNQQLEIQMSYLSRIEF 296

Query: 298 ARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPES 357
            +++L  SR+I+  + ++ ++I N Y PEHLII  +N    V+ I +AG+VFLG W+ E+
Sbjct: 297 IKRSLANSRIIICSNQSEQLDIINSYAPEHLIINRKNPEPWVEKIVAAGTVFLGSWAAET 356

Query: 358 AGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLT 417
            GDY +G+NHVLPT G+    S L   DF  R TVQ +++E    L     TLA  E L 
Sbjct: 357 MGDYVTGSNHVLPTSGFARNHSGLSTLDFMTRFTVQAINQEAIRNLGPAAMTLAELEGLD 416

Query: 418 AHKNAVTLRVNALKE 432
           AH NAV +R+N L +
Sbjct: 417 AHANAVQIRLNTLGD 431


>UniRef50_D2RJQ0 Histidinol dehydrogenase n=7 Tax=Firmicutes RepID=D2RJQ0_ACIFE
          Length = 448

 Score =  539 bits (1390), Expect = e-152,   Method: Composition-based stats.
 Identities = 176/450 (39%), Positives = 257/450 (57%), Gaps = 27/450 (6%)

Query: 5   TIIDWNSCTAEQQRQLLMRPAISA---SESITRTVND--------------ILDNVKARG 47
            + D    TAE+  +LL + +      S  +   V                I+++++ +G
Sbjct: 2   KVYDERKSTAEEISRLLEKKSFDEVKLSPKVAAAVEKMFGRPLTAAEEVDIIVNDIRNKG 61

Query: 48  DEALREYSAKFDKTTVTA--LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLP 105
           DEAL EY+ K D   +    ++V+ EE A A + + ++   A+  A+ N+  FH  Q   
Sbjct: 62  DEALFEYTKKLDGADLRPATIRVTEEEFAEAEKAVDEKTMGAIRRAIANVRKFHEEQLPK 121

Query: 106 PVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP-- 163
                   G    Q   PV SVG+Y+PGG+A   S+V+M A PA +AG  ++ + +P   
Sbjct: 122 TWLTPRAYGSFLGQKMTPVDSVGIYVPGGTAAYPSSVIMNAVPAKVAGVPRIAMAAPAGR 181

Query: 164 --PIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQV 221
              +   +L  A+  G+ +++ +GGAQAIAALAFGTE++PKV+KI GPGN FVT AK+ V
Sbjct: 182 DGKMNPYVLATAKEIGITEIYKMGGAQAIAALAFGTETIPKVEKITGPGNIFVTLAKKAV 241

Query: 222 SQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRV 281
              +D   IDM AGPSE+L++AD  A   ++A+DLLSQAEH P +  IL+T   D+A +V
Sbjct: 242 YGHVD---IDMLAGPSEILIVADKTADYQYLAADLLSQAEHDPLACAILITDDEDLAGKV 298

Query: 282 AEAVERQLAELPRAETARQALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVD 340
           AE VE QL +LPR E A Q+L    ++I+ KD+   VE++N   PEH+ I TR    LV 
Sbjct: 299 AEEVEVQLQKLPRKEIAAQSLAVQGKIILAKDMDTVVEMANISAPEHMEINTREPFALVP 358

Query: 341 SITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGF 400
            I +AG++FLG +SPE  GDY +G NH+LPT G     S L +  F K+ ++   +KE  
Sbjct: 359 RIRNAGAIFLGAYSPEPLGDYYAGPNHILPTGGTARFYSVLNVETFMKKTSIISYTKEAL 418

Query: 401 SALASTIETLAAAERLTAHKNAVTLRVNAL 430
           +  A  I  +A AE L AH NA+ +R  AL
Sbjct: 419 AEAADDIIAMAEAEGLQAHANAIRIRKGAL 448


>UniRef50_Q3AR25 Histidinol dehydrogenase n=13 Tax=Bacteria RepID=HISX_CHLCH
          Length = 428

 Score =  539 bits (1389), Expect = e-152,   Method: Composition-based stats.
 Identities = 150/425 (35%), Positives = 227/425 (53%), Gaps = 10/425 (2%)

Query: 13  TAEQQRQLLMR--PAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSA 70
             ++   L  R    +S  E+  + V++IL  V+ +GD A+  Y+ +F    +T+++V  
Sbjct: 7   FPQEASALQERLVRHVSFDEAAHKAVDEILAKVRQQGDRAVLNYTEQFQGVRLTSMQVDE 66

Query: 71  EEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLY 130
           E I  A       L   +  A  NI  FH  +       E + GV   Q  RP+    LY
Sbjct: 67  EAIEMAYRHADPSLIATLHEAYANIVRFHEHEVERSFFYEAEGGVLLGQRVRPMERAMLY 126

Query: 131 IPGGSAPLFSTVLMLATPASIAGCKKVVLCSP----PPIADEILYAAQLCGVQDVFNVGG 186
           +PGG A   S++LM A PA +AG  ++ + +P      +   IL AA++ G+  ++ +GG
Sbjct: 127 VPGGKAAYPSSLLMNAAPAKVAGVCEIAVTTPCDATGVVNPTILAAAKVAGISSIYKIGG 186

Query: 187 AQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSG 246
           AQA+AA A+GTES+PKVD I GPGN +V  AK+QV   +   AID  AGPSEV++IAD  
Sbjct: 187 AQAVAAFAYGTESIPKVDIITGPGNKYVALAKKQVFGHV---AIDSIAGPSEVVIIADES 243

Query: 247 ATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAE-TARQALNAS 305
           A  +FVA D+ +QAEH PD+  +L+T +   A+ V +AV   L  + R E  A   L+  
Sbjct: 244 AHAEFVALDMFAQAEHDPDASAVLITTSESFAQAVQQAVASLLPTMLRHETIASSLLHNG 303

Query: 306 RLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGT 365
            +++   L     +S+   PEHL +      +++  +  AG++F+G +S E+ GDY +G 
Sbjct: 304 AMVLVPSLDDACAVSDMLAPEHLELHVVQPWDILPKLKHAGAIFMGSYSCETIGDYFAGP 363

Query: 366 NHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTL 425
           NH LPT G     S L + DF K  ++   S E   +  + I   A AE L AH  AV +
Sbjct: 364 NHTLPTSGTARFFSPLSVRDFVKHTSIISYSPEQLRSKGAQIAAFADAEGLQAHAEAVRV 423

Query: 426 RVNAL 430
           R+  L
Sbjct: 424 RLKTL 428


>UniRef50_C7LV94 Histidinol dehydrogenase n=6 Tax=Desulfovibrionales
           RepID=C7LV94_DESBD
          Length = 436

 Score =  537 bits (1385), Expect = e-151,   Method: Composition-based stats.
 Identities = 160/438 (36%), Positives = 236/438 (53%), Gaps = 19/438 (4%)

Query: 1   MSFNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDK 60
           + + +  DW +  +   R+       +  +++   V DIL  V+ RGDEA+ EY+ +FD 
Sbjct: 6   LEYTSPNDWTAIASWMARR------DAGEDNVEPLVRDILAQVRERGDEAVAEYTRRFDC 59

Query: 61  TTVTA--LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQ 118
            +++A  L V   +I  A E +  E    +  A  NI  FH  QK         PG    
Sbjct: 60  PSLSAAGLPVPKADIGRALELIPAEDAAIIREAAANIRDFHLRQKQNSWITTPAPGTTLG 119

Query: 119 QVTRPVASVGLYIPGGSA---PLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILY 171
           Q+  PV   GLY+PGG     PL S++LM A PA +AG   + + SPP     +   IL 
Sbjct: 120 QLVLPVDRAGLYVPGGQGGETPLISSLLMNAIPAQVAGVGAICVVSPPRKDGTLNPYILA 179

Query: 172 AAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAID 231
            A + G+  +F  G A AIAALA+GT S+P+VD I GPGN FVT AKR +  ++    ID
Sbjct: 180 TAAILGIDTIFMCGSAWAIAALAYGTASIPRVDVIAGPGNIFVTTAKRLLVGQV---GID 236

Query: 232 MPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAE 291
           M AGPSE+ ++ADS A P ++A+D+LSQAEH P +  IL++    +   V + + RQL  
Sbjct: 237 MIAGPSEIAILADSTANPKWLAADMLSQAEHDPLASSILISADQQLLEEVKKELARQLPA 296

Query: 292 LPRAETARQAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFL 350
           LPR E A ++L   S LI   DL   +++ N+  PEH  +   +   LV ++ +AG+VF+
Sbjct: 297 LPRQEIASKSLSEWSALIHVPDLEMGMDLINRLAPEHFELSVADPWALVGAVRNAGAVFM 356

Query: 351 GDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETL 410
           G  +PE  GDY +G NHVLPT       S+L +  F K+ ++    +   ++  S +  L
Sbjct: 357 GHSTPEPVGDYFAGPNHVLPTLSTARFSSALSVDTFCKKTSLICTDQAYMNSHGSKVARL 416

Query: 411 AAAERLTAHKNAVTLRVN 428
           A  E L AH  +V  R+ 
Sbjct: 417 ARLEGLEAHARSVEQRLE 434


>UniRef50_B2A652 Histidinol dehydrogenase n=1 Tax=Natranaerobius thermophilus
           JW/NM-WN-LF RepID=B2A652_NATTJ
          Length = 428

 Score =  537 bits (1384), Expect = e-151,   Method: Composition-based stats.
 Identities = 165/421 (39%), Positives = 245/421 (58%), Gaps = 11/421 (2%)

Query: 16  QQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAA 75
           ++ +L  + A         TV  I+D V+  GD+AL E +   D  +++ L+VS E +  
Sbjct: 5   KEAKLASQKAKFEDVETRNTVTKIIDQVRTNGDKALFELTQSLDNCSLSKLEVSQEYMKQ 64

Query: 76  ASERLSDELKQAMAVAVKNIETFHTAQK--LPPVDVETQPGVRCQQVTRPVASVGLYIPG 133
             + L+D+ K+A+  A   IE F + Q      ++ E  PGV+     +P++S G Y+P 
Sbjct: 65  CYDNLTDKTKEALNFAKDQIEFFASQQLAGFKEIECENIPGVKLGYKIKPISSCGCYVPA 124

Query: 134 GSAPLFSTVLMLATPASIAGCKKVVLCSPP-----PIADEILYAAQLCGVQDVFNVGGAQ 188
           G  PL S+ LM   PA +AG +++V  +PP      I  E+L A  L GV +V+ VGGA 
Sbjct: 125 GRYPLPSSALMSIVPARVAGVERIVAIAPPVRKYGGIHPELLAAMYLAGVDEVYIVGGAH 184

Query: 189 AIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGAT 248
            IAALA GTE++ KVD I GPGN +VTEAKRQ++  +    ID  AGPSEVL+IAD+ A+
Sbjct: 185 GIAALALGTETISKVDFIVGPGNKYVTEAKRQLNGIV---GIDQLAGPSEVLIIADNTAS 241

Query: 249 PDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRL 307
              VA+DLL+QAEH PD+  +L+T +  +A+ V + + RQL EL   ETA ++  +   +
Sbjct: 242 STNVAADLLAQAEHDPDAVCVLVTTSEQLAKEVNQEIHRQLDELLTWETAAKSWEDYGEI 301

Query: 308 IVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNH 367
           I+  +L Q +EIS+Q  PEHL + T N   +++ +   GS+F+G+W+  + GDY SGTNH
Sbjct: 302 ILVDNLDQAIEISDQMAPEHLQLMTDNNSNIMEMVNHYGSLFVGEWASVAFGDYVSGTNH 361

Query: 368 VLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRV 427
           +LPT       S L +  F K  + Q L++ G   L+     LA  E L AHK +  LR 
Sbjct: 362 ILPTGNSARFSSGLSVGKFLKMSSYQVLTETGAHELSDKCMHLAELEGLEAHKKSAELRA 421

Query: 428 N 428
           +
Sbjct: 422 D 422


>UniRef50_B3TCH3 Putative Histidinol dehydrogenase n=1 Tax=uncultured marine
           microorganism HF4000_APKG10K24 RepID=B3TCH3_9ZZZZ
          Length = 444

 Score =  536 bits (1382), Expect = e-151,   Method: Composition-based stats.
 Identities = 160/422 (37%), Positives = 246/422 (58%), Gaps = 13/422 (3%)

Query: 18  RQLLMRPAISASESI--TRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAA 75
           + +L R   +  E +   ++V  +L +V+  GD A+R YS   D   +++ KV  E++A 
Sbjct: 25  KAVLDRTHQAFGEDVSPEQSVLKMLQDVRQDGDAAVRRYSKLLDGVELSSFKVEKEQLAQ 84

Query: 76  ASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGS 135
           A+  +S EL++++ +A + I  FH A        E        Q+ RP+  VGLY PGG+
Sbjct: 85  AAASVSTELRESLELAAERIRQFHQAVMPKDWLDEEGG---LGQLVRPLERVGLYAPGGT 141

Query: 136 APLFSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQDVFNVGGAQAIA 191
           A   STVLM A PA +AG  +V+LC+P      +   +L AA++ GV  V+ +GG  AI 
Sbjct: 142 AAYPSTVLMTAIPARVAGVNEVILCTPARPGEALNPAVLVAAEISGVDTVYQIGGVPAIG 201

Query: 192 ALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDF 251
           A+A+GT+SVPKVDKI GPGN FV  AK+ V  ++D   ID   GP+E +VIAD  A P F
Sbjct: 202 AMAYGTDSVPKVDKICGPGNVFVAYAKKLVQGQVD---IDGVFGPTETVVIADESADPGF 258

Query: 252 VASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALN-ASRLIVT 310
            A+DL+ QAEH P +  IL+T + D+  RV   ++ QL    R + ARQAL    R+++ 
Sbjct: 259 CAADLIGQAEHDPLATAILITDSQDLIDRVERELDEQLNIQLRGDLARQALERQGRIVLV 318

Query: 311 KDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLP 370
           + +A+ VE++++  PEH+ +  ++  +   ++  AG +FLG++SPE  GDY +G +HV+P
Sbjct: 319 ESVAEAVELADRIAPEHMCLMVQDPWKWAGTVKHAGGLFLGEYSPEVMGDYVAGPSHVMP 378

Query: 371 TYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNAL 430
           T G     S+L +  F + M V  LS + F  L      +A AE L  H  AV +R++ L
Sbjct: 379 TGGTARFSSALSVHQFLRTMPVVSLSADDFQKLGPAAIEIAKAEGLDGHATAVRMRLDKL 438

Query: 431 KE 432
           ++
Sbjct: 439 QK 440


>UniRef50_C1PFR7 Histidinol dehydrogenase n=1 Tax=Bacillus coagulans 36D1
           RepID=C1PFR7_BACCO
          Length = 427

 Score =  534 bits (1377), Expect = e-150,   Method: Composition-based stats.
 Identities = 151/405 (37%), Positives = 229/405 (56%), Gaps = 8/405 (1%)

Query: 29  SESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAM 88
            E + RT  ++L++++  GD A+++Y+AKFD     + +V  EE   A   +  ++  A+
Sbjct: 25  DEGVLRTAKEVLEDIRLNGDAAVKKYTAKFDGEVPESWEVLPEERKQAWHEVPQDVISAL 84

Query: 89  AVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATP 148
             A +NI  FH  Q      +E    +   Q+ RPV   G+Y+PGG+A   S+VLM A P
Sbjct: 85  QKAAENIRRFHAKQLQNSRIMEMNENIISGQLFRPVEKAGIYVPGGTACYPSSVLMNAIP 144

Query: 149 ASIAGCKKVVLCSP----PPIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVD 204
           A +AG ++V++ +P      IA  +  AA + GV  ++ +GG QAI ALA+GTE++PKVD
Sbjct: 145 AVLAGVEEVIMATPARNGTKIAPVLSVAADIAGVGTIYKLGGIQAIGALAYGTETIPKVD 204

Query: 205 KIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGP 264
           KI GPGNA+V  AK  V   +    IDM AGPSEV +IAD  A P ++A+DL++QAEH  
Sbjct: 205 KIVGPGNAYVAAAKSLVYGTV---GIDMIAGPSEVAIIADENANPVYIAADLIAQAEHDE 261

Query: 265 DSQVILLTPAADMARRVAEAVERQLAELPRAETARQALN-ASRLIVTKDLAQCVEISNQY 323
            ++  L T +  +      A+E+QL  LPR +    ++   S  ++ + + +   +SN+ 
Sbjct: 262 RARTFLFTTSQKLINETKSALEKQLVVLPRRDIGEVSIKMQSAAVLVESIDEAFALSNRL 321

Query: 324 GPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGL 383
            PEHL IQ  N    +  + +AGSVFLG+ +PE+ GDY  G NH+LPT G     S L +
Sbjct: 322 APEHLEIQVENPLLQLSKVKNAGSVFLGENTPEAIGDYYGGPNHILPTSGTARFSSGLSV 381

Query: 384 ADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVN 428
            DF K++T     ++     A  +  +A  E+L  H  AV  RV 
Sbjct: 382 DDFYKKITYLYYGEKALQQAAPDVMAIATEEQLAGHARAVQKRVK 426


>UniRef50_P62457 Histidinol dehydrogenase n=27 Tax=cellular organisms
           RepID=HISX_DESVH
          Length = 436

 Score =  532 bits (1372), Expect = e-150,   Method: Composition-based stats.
 Identities = 171/410 (41%), Positives = 234/410 (57%), Gaps = 13/410 (3%)

Query: 27  SASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA--LKVSAEEIAAASERLSDEL 84
              +++   V DIL  V+++GDEAL EY+ +FD    T   L V++EE+A A   +  + 
Sbjct: 26  DPDDAVEPVVRDILAAVRSKGDEALAEYTRRFDCPDFTPALLHVTSEEVAQAVASVPADD 85

Query: 85  KQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSA---PLFST 141
              +  A  NI +FH AQK     V    G    Q   PV   GLY+PGG     PL S+
Sbjct: 86  IAIIRQAADNIRSFHEAQKERSWFVTHDDGTILGQKVTPVDRAGLYVPGGKGGDTPLLSS 145

Query: 142 VLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQDVFNVGGAQAIAALAFGT 197
           +LM A PA +AG   + + SPP     +   +L AA + G+ D+   G A A+AA AFGT
Sbjct: 146 LLMNAIPAQVAGVTSITVASPPRPDGTLNPHLLAAAHILGITDIIRAGSAWAVAAFAFGT 205

Query: 198 ESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLL 257
           +++  VD I GPGN FVT AKR V  R+   AIDM AGPSE+L++AD+ A PD+VA+D+L
Sbjct: 206 QTIAPVDVIAGPGNIFVTTAKRMVQGRV---AIDMIAGPSEILILADATARPDWVAADML 262

Query: 258 SQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQC 316
           SQAEH P +  IL+T    +A  V   +ERQLA LPRA+ AR+AL +   ++V  D+   
Sbjct: 263 SQAEHDPLASSILVTTEPALAEAVTAELERQLATLPRADIARKALADWGAVVVVPDMDVA 322

Query: 317 VEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTA 376
           V I+N+  PEHL + T    EL  S+  AG++FLG +SPE  GDY +G NHVLPT G   
Sbjct: 323 VAIANRVAPEHLEVLTAQPWELAGSLRHAGALFLGPYSPEPLGDYFAGPNHVLPTMGTAR 382

Query: 377 TCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
             S+L +  F KR ++   S+      A  +  LA  E L AH  +   R
Sbjct: 383 FSSALSVQTFCKRTSIIAASRAFAERNADAVARLARLEGLEAHARSAASR 432


>UniRef50_Q186D5 Histidinol dehydrogenase n=9 Tax=Bacteria RepID=Q186D5_CLOD6
          Length = 421

 Score =  531 bits (1370), Expect = e-149,   Method: Composition-based stats.
 Identities = 158/407 (38%), Positives = 233/407 (57%), Gaps = 12/407 (2%)

Query: 32  ITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAMAVA 91
           +   V+ I+++++   D AL++Y+ KFD+ T    +++ EEI  A + + DE    + +A
Sbjct: 18  LREQVSSIIEDIRNNKDVALKKYNEKFDRNTRDEFRITKEEIKEAYKHVDDEFINNLKIA 77

Query: 92  VKNIETFHTAQKL---PPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATP 148
            KNI  F  AQKL    P + E  PGV   Q   P+ S   Y+PGG  PLFST LML  P
Sbjct: 78  AKNIREFAKAQKLSFENPFEKEIYPGVILGQTNIPIESCLAYVPGGQYPLFSTALMLIIP 137

Query: 149 ASIAGCKKVVLCSPP-----PIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKV 203
           A +AG K++V CSP       I  + L A  + G  +++  GG QAIAA  +GTE +  V
Sbjct: 138 AKVAGVKRIVACSPTMKNTEKINPKTLVAMDIAGADEIYATGGVQAIAAFTYGTEKINPV 197

Query: 204 DKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHG 263
           D I GPGN FVTEAKRQ   ++    ID  AGPSEVL+IAD  + P ++A+DLL+Q EH 
Sbjct: 198 DIIVGPGNKFVTEAKRQCYGQV---GIDFVAGPSEVLIIADETSNPVYIAADLLAQCEHD 254

Query: 264 PDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVEISNQ 322
            +++ ILLT + ++A++V + +E  L +LP  + +  +  N   +I+  D+ + ++ISN 
Sbjct: 255 LNARGILLTNSLEVAQKVEKNIESMLKDLPTKDISYSSWENNGEIILVDDMEEAIKISNF 314

Query: 323 YGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLG 382
           Y PEHL +      ++ D +T+ GS+F+G+ S E  GDY SGTNH LPT   +     + 
Sbjct: 315 YAPEHLEVAVNEYNDICDRLTNYGSLFIGNLSAEVFGDYVSGTNHTLPTLKASRYTGGVW 374

Query: 383 LADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNA 429
           +  F K  T Q  +++   +LA   E LA  E L AH  A  +R   
Sbjct: 375 VGTFIKTCTKQIFNEKAIQSLAPVAEKLAKEEGLYAHAKAAEVRFKK 421


>UniRef50_C3XDE7 Histidinol dehydrogenase n=1 Tax=Helicobacter bilis ATCC 43879
           RepID=C3XDE7_9HELI
          Length = 452

 Score =  531 bits (1368), Expect = e-149,   Method: Composition-based stats.
 Identities = 156/455 (34%), Positives = 242/455 (53%), Gaps = 28/455 (6%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              I++ +    E +   L+  A +  +SI   V   L ++K RG++AL +   K+D   
Sbjct: 1   MIKILNIHDKDFETEFNTLLARANTDMDSIIPEVLKTLQDIKQRGEDALLDIVRKYDSWN 60

Query: 63  V---TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQ 119
                 LK++ E+   A + L  + K A+ +A   I TFH            +      Q
Sbjct: 61  PQTFNDLKIAEEDTFNAYKNLDSKTKDALQIAHDRIYTFHAKNAPKGFIYHDEYANMLGQ 120

Query: 120 VTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLC 176
              P+   G+YIPGG A   S++LM A PA +AG K++++ SP P   I + +L A  LC
Sbjct: 121 NIMPIQRAGIYIPGGKAFYPSSLLMNAIPAKVAGVKEIIMASPTPNNHINELVLAAMYLC 180

Query: 177 GVQDVFNVGGAQAIAALAFG--------------TES----VPKVDKIFGPGNAFVTEAK 218
           G+++ + +GG  AI   A+G              T++      KVD I GPGN +V  AK
Sbjct: 181 GIKEGYKIGGIGAIGMFAYGFGETKWSKDSLFSHTKTTQKGFKKVDVITGPGNIYVATAK 240

Query: 219 RQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMA 278
           + V   ++   IDM AGPSE+ +IADS A  D++A D+LSQAEH   +  IL+T   D+A
Sbjct: 241 KLVFGEVN---IDMIAGPSEIGIIADSHANSDYLAIDMLSQAEHDSMASAILITDNKDLA 297

Query: 279 RRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARE 337
           + VA+ ++ +L  L R + A++++     +I+ ++L Q   + N   PEHL I T+    
Sbjct: 298 KEVAQKIDTKLTHLMRKDIAQKSIQERGAIIIVENLKQAAMLMNAIAPEHLEIVTQEPFS 357

Query: 338 LVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSK 397
           L+  I +AG+VFLG ++PE+ GDY +G NH LPT G     S LG+  F  R ++   SK
Sbjct: 358 LLGEIKAAGAVFLGHYTPEAIGDYLAGPNHTLPTGGSARFFSPLGVEHFCTRSSLISFSK 417

Query: 398 EGFSALASTIETLAAAERLTAHKNAVTLRVNALKE 432
           +G   LA+    LA  E L AHK +V  R++++K+
Sbjct: 418 QGIKNLANPCAILAETEGLEAHKLSVISRLDSMKD 452


>UniRef50_Q3J079 Histidinol dehydrogenase 1 n=26 Tax=Proteobacteria
           RepID=HISX1_RHOS4
          Length = 434

 Score =  530 bits (1366), Expect = e-149,   Method: Composition-based stats.
 Identities = 171/432 (39%), Positives = 242/432 (56%), Gaps = 9/432 (2%)

Query: 7   IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTAL 66
           +D      E     L+      S  +   V  I+ +V+ARGD A+ E +A+FD+  +T  
Sbjct: 5   LDTRRPGFEADFTALLGMKREDSPDVDAVVAGIIADVRARGDAAVIELTARFDRLELTPE 64

Query: 67  KV--SAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPV 124
           ++  S  EI A    +S E + A+ +A + I  +H  Q           G        P+
Sbjct: 65  RLAFSEAEIEAEIATVSAEDRAALELAAERIRAYHARQMPENARWTDAAGAELGWRWGPI 124

Query: 125 ASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCGVQDV 181
           AS GLY+PGG A   S+VLM A PA +AG +++V+  P P   +   +L AA+L GV  V
Sbjct: 125 ASAGLYVPGGLASYPSSVLMNAIPARVAGVERLVVACPTPGGVVNPLVLLAARLAGVDAV 184

Query: 182 FNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLV 241
           + +GGAQA+AALA+GTE++  VDKI GPGNA+V  AKR+V  R+    IDM AGPSE+LV
Sbjct: 185 YRIGGAQAVAALAYGTETIRPVDKITGPGNAYVAAAKRRVFGRV---GIDMIAGPSEILV 241

Query: 242 IADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQA 301
           IA+    PD++A DLLSQAEH   +Q IL+TP   + R V +AVE +L  L R   A  +
Sbjct: 242 IAEGAVDPDWIALDLLSQAEHDESAQSILVTPDEALGRAVVQAVEARLETLERRAIAGAS 301

Query: 302 L-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGD 360
             +   +IVT+DL +   +S++  PEHL +   +   L   I  AG++FLG W+PE+ GD
Sbjct: 302 WRDYGAVIVTRDLEEAAALSDRVAPEHLELCVADPEALAARIRHAGAIFLGGWTPEAIGD 361

Query: 361 YASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHK 420
           Y  G NHVLPT       S L + DF KR T+  ++     A+    E LA +E L AH 
Sbjct: 362 YVGGPNHVLPTARSARFSSGLSVMDFLKRTTLARMTPAALRAVGPAAERLAISESLEAHG 421

Query: 421 NAVTLRVNALKE 432
            +V  R++ L E
Sbjct: 422 LSVRARLDRLNE 433


>UniRef50_Q46WL2 Histidinol dehydrogenase 1 n=202 Tax=Bacteria RepID=HISX1_RALEJ
          Length = 445

 Score =  530 bits (1366), Expect = e-149,   Method: Composition-based stats.
 Identities = 173/434 (39%), Positives = 244/434 (56%), Gaps = 14/434 (3%)

Query: 7   IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT---V 63
           +D +     Q  + ++       E+I R V  IL +VK RGD A+ EY+ +FD+     +
Sbjct: 14  LDSSDPRFAQALREVLAFEAGEDEAIDRAVAQILADVKDRGDAAVLEYTQRFDRVEAASM 73

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLP----PVDVETQPGVRCQQ 119
            AL++S  E+ AA E L  + + A+  A   +  +H  QK+       +     G    Q
Sbjct: 74  GALEISQSELEAALEDLEPKRRAALEAAAARVRAYHEKQKIECGSHSWEYTEADGTMLGQ 133

Query: 120 VTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLC 176
              P+  VG+Y+PGG A   S+VLM A PA +AG K++++  P P     + +L AAQ+ 
Sbjct: 134 KVTPLDRVGIYVPGGKAAYPSSVLMNAIPARVAGVKEIIMVVPTPGGVRNELVLAAAQIA 193

Query: 177 GVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGP 236
           GV  VF +GGAQA+ ALA+GT ++P+VDKI GPGNA+V  AKR+V   +    IDM AGP
Sbjct: 194 GVDRVFTIGGAQAVGALAYGTATLPQVDKIVGPGNAYVAAAKRRVFGTV---GIDMIAGP 250

Query: 237 SEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAE 296
           SE+LVI D    PD+VA DL SQAEH   +Q ILL P AD   +V  +++RQL  +PR E
Sbjct: 251 SEILVICDGTTDPDWVAMDLFSQAEHDELAQSILLCPDADYIAQVEASIQRQLDSMPRRE 310

Query: 297 TARQALNA-SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSP 355
               +++    LI  +D+ +  EI+N   PEHL I   N R+  + I  AG++FLG ++ 
Sbjct: 311 VIAASISGRGALIKVRDMEEACEIANAIAPEHLEISAENPRQWSEKIRHAGAIFLGRYTS 370

Query: 356 ESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAER 415
           ES GDY +G NHVLPT       S LG+ DFQKR ++ E+S+ G   L      LA  E 
Sbjct: 371 ESLGDYCAGPNHVLPTSRTARFSSPLGVYDFQKRSSLIEVSEGGAQMLGQIAAELAYGEG 430

Query: 416 LTAHKNAVTLRVNA 429
           L AH  +   R   
Sbjct: 431 LQAHARSAEYRFKR 444


>UniRef50_Q313T7 Histidinol dehydrogenase n=7 Tax=Deltaproteobacteria
           RepID=HISX_DESDG
          Length = 434

 Score =  529 bits (1363), Expect = e-148,   Method: Composition-based stats.
 Identities = 167/438 (38%), Positives = 249/438 (56%), Gaps = 14/438 (3%)

Query: 1   MSFNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFD- 59
           M   T+   +    +  R +L     +   S+   V +I+D +++ GD AL  Y+ +FD 
Sbjct: 1   MPCRTLTYSSEADWQGIRDMLC-GRENPENSVEPVVREIMDAIRSDGDAALAGYTRRFDC 59

Query: 60  -KTTVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQ 118
                ++L+V+ + I  A+  +     Q +  A  NI  FH+AQK     +    G    
Sbjct: 60  PDFDPSSLRVAPDAIEKAAREIPRHDLQIITEAADNIRHFHSAQKEEAWFITRPDGTVLG 119

Query: 119 QVTRPVASVGLYIPGGSA---PLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILY 171
           Q+TRPV S GLY+PGG     PL S++LM A PA +AG  ++ + +PP     +   IL 
Sbjct: 120 QMTRPVDSAGLYVPGGQGGNTPLISSLLMNAVPAQVAGVPRIAVTTPPRKDGTLNPYILA 179

Query: 172 AAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAID 231
           AA + G+ +++  G A A+AALA+GT+++  VD I GPGN FVT AKR +   +    ID
Sbjct: 180 AAHVLGLDEIYCAGSAWAVAALAYGTQTIAPVDFIAGPGNIFVTTAKRMLIGTV---GID 236

Query: 232 MPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAE 291
           M AGPSE+L+IADS A    VA+D+LSQAEH P +  IL+TP+  +A  V   +E+Q+  
Sbjct: 237 MIAGPSEILIIADSQADAAHVAADMLSQAEHDPLASAILVTPSPQLAAAVHTELEKQVTG 296

Query: 292 LPRAETARQAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFL 350
           L RA+ AR +L + S ++VT DL   VE+SN+  PEHL +  ++   L+ SI +AG++F+
Sbjct: 297 LDRADIARASLRDWSAIVVTPDLNSAVELSNKVAPEHLELLVQDTWGLLGSIRNAGAIFM 356

Query: 351 GDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETL 410
           G  SPE  GDY +G NHVLPT G     S+L +  F K+ ++   S+      A+ I  L
Sbjct: 357 GPHSPEPVGDYFAGPNHVLPTMGTARFSSALSVQSFCKKSSIIAASQTFTQTNAAKIARL 416

Query: 411 AAAERLTAHKNAVTLRVN 428
           A  E L AH  +V  R++
Sbjct: 417 ARLEGLEAHARSVESRLS 434


>UniRef50_D1YWF4 Histidinol dehydrogenase n=1 Tax=Methanocella paludicola SANAE
           RepID=D1YWF4_METPS
          Length = 423

 Score =  528 bits (1361), Expect = e-148,   Method: Composition-based stats.
 Identities = 166/429 (38%), Positives = 237/429 (55%), Gaps = 13/429 (3%)

Query: 6   IIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA 65
           I            ++  R   ++  S+  T   + D V+  GD A+R+Y+ +FD   +  
Sbjct: 2   IKQLYGVDDAALDEVFKRR--TSISSVMDTAKKVADEVREGGDAAVRKYTKQFDGVDLRD 59

Query: 66  LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPP--VDVETQPGVRCQQVTRP 123
           L+V+ +E+  A E +  E    +  A+ NIE FH  Q+        E  PG+R  Q   P
Sbjct: 60  LEVTDDEMYNAVELIDYETIGHLEKAIDNIEAFHALQRPSGDMWLTEISPGIRLGQKFTP 119

Query: 124 VASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQ 179
           +  +G Y+PGG+    ST LML  PA +AG  +++ C+PP     I    L A  + G  
Sbjct: 120 LERIGAYVPGGTGSYPSTALMLIVPAQVAGVSEIIACTPPRKDGTIHPLTLTALDMAGAD 179

Query: 180 DVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEV 239
            +F VGG QAIAA+A+GT+S+PKV+KI GPGN +VT AK  V    D A IDMPAGPSE+
Sbjct: 180 RIFKVGGVQAIAAMAYGTQSIPKVEKIVGPGNIYVTAAKMYVR---DAAEIDMPAGPSEI 236

Query: 240 LVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETAR 299
           +VIAD  A P F+ASD+++QAEH  ++  ILLTP+  +A  V   +ERQ    PR +   
Sbjct: 237 VVIADDTAIPSFIASDMIAQAEHDVNAMSILLTPSEMLAESVELEIERQKENAPRRQIID 296

Query: 300 QALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAG 359
           +A     + V  DL   VE+ N+  PEH+ I  R+    ++ + +AG+V++GD++P +AG
Sbjct: 297 KA--GMGIYVLDDLDAAVEVCNRIAPEHVEIMVRDPMSTLNKVRNAGTVYVGDYAPVAAG 354

Query: 360 DYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAH 419
           DYASG NHVLPT GY    S +    F K  +VQ + K G   +  TI  LA  E   AH
Sbjct: 355 DYASGANHVLPTGGYAKVFSGMNTMQFIKTTSVQVIEKGGLEGIKDTITALAEIEGFDAH 414

Query: 420 KNAVTLRVN 428
             +V  R  
Sbjct: 415 ARSVYKRFE 423


>UniRef50_Q4P7D9 Putative uncharacterized protein n=3 Tax=Eukaryota
           RepID=Q4P7D9_USTMA
          Length = 896

 Score =  527 bits (1359), Expect = e-148,   Method: Composition-based stats.
 Identities = 206/458 (44%), Positives = 276/458 (60%), Gaps = 34/458 (7%)

Query: 7   IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVT-A 65
             +   +A Q+++LL RPA+  +E +      IL +VK RGD AL E + KFDK  +T A
Sbjct: 441 YRYEDLSAAQRKELLKRPALR-TEQVMDICRPILRSVKERGDAALLELTEKFDKAKLTNA 499

Query: 66  LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLP-------------------- 105
           +++      +   ++  E+K A+ +A  NI  FH AQK                      
Sbjct: 500 VRLPPFVDDSVMAQIKPEVKVAIDIAYNNIYKFHKAQKTTFGNKSAGATGSGSADGSEGA 559

Query: 106 ---PVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSP 162
               ++VET PGV C++  RP+ SVGLY+PGGSA L ST LML  PA +A C  VV+ +P
Sbjct: 560 QDGVLEVETMPGVVCRRFARPIESVGLYVPGGSAVLPSTALMLGVPAQVARCPTVVIATP 619

Query: 163 P----PIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAK 218
           P     I+ E+LY A       +   GGAQA+AALA+GTES PKVDKI GPGN FVT AK
Sbjct: 620 PRADGSISPEVLYCASKVNASAILCAGGAQAVAALAYGTESCPKVDKIVGPGNQFVTAAK 679

Query: 219 RQVSQRLDG-AAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILL---TPA 274
             V    D   +IDMPAGPSEVLVIAD  A   FVASDLLSQAEHGPDSQV+L+     +
Sbjct: 680 MLVQNETDAIVSIDMPAGPSEVLVIADREADAAFVASDLLSQAEHGPDSQVVLVGIALSS 739

Query: 275 ADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRN 334
           +++A  +   V+RQ   LPR +  RQA++ S  ++  D A  +E SN Y PEHLI+QTR+
Sbjct: 740 SELA-AIEAEVDRQARALPRVDVVRQAIDKSVTVIVPDRATAMEWSNAYAPEHLILQTRD 798

Query: 335 ARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQE 394
           A  LV+ + +AGS+F+G WSPES GDY SGTNH LPT  Y  + S + +A F+K +T Q 
Sbjct: 799 AESLVECVQNAGSIFVGPWSPESCGDYMSGTNHSLPTAAYAKSYSGVNVATFEKCITSQS 858

Query: 395 LSKEGFSALASTIETLAAAERLTAHKNAVTLRVNALKE 432
           L+++G    A  +  LA  E L AH  AV +R++ ++ 
Sbjct: 859 LTQQGLKGFAQNVIDLAMCEGLQAHAMAVKIRLDRIQS 896


>UniRef50_Q9P777 Histidinol dehydrogenase n=71 Tax=cellular organisms
           RepID=HISX_SCHPO
          Length = 439

 Score =  525 bits (1353), Expect = e-147,   Method: Composition-based stats.
 Identities = 193/427 (45%), Positives = 267/427 (62%), Gaps = 9/427 (2%)

Query: 7   IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTAL 66
               + TAE++ +LL RP  + ++ I   V  I+++VK+RG+ +L +Y++KF+K  + + 
Sbjct: 11  YRAAALTAEERTRLLARPIQN-TQKIRTIVQPIIEDVKSRGEASLIDYASKFEKVQLKS- 68

Query: 67  KVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVAS 126
            V          ++S  +K+ + +A  NI  FH++Q  P + V+T  GV CQ+++RP+  
Sbjct: 69  AVLKAPFDDDLMKISPMIKEDIDIAFNNIFAFHSSQLRPTIAVQTMRGVVCQRMSRPINR 128

Query: 127 VGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSP----PPIADEILYAAQLCGVQDVF 182
           VGLYIPGG+A L ST LML  PA +AGC  VV+ +P      +A EI+Y A   G + + 
Sbjct: 129 VGLYIPGGTAVLPSTALMLGVPAKVAGCPHVVISTPVRKDGTVAPEIVYIANKIGAEAII 188

Query: 183 NVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDG-AAIDMPAGPSEVLV 241
             GGAQAIAA+A+G   VPKV+KIFGPGN FVT AK  V        AID+PAGPSEVLV
Sbjct: 189 LAGGAQAIAAMAYGISGVPKVNKIFGPGNQFVTAAKMHVQNDYGALVAIDLPAGPSEVLV 248

Query: 242 IADSGATPDFVASDLLSQAEHGPDSQVILLTPA--ADMARRVAEAVERQLAELPRAETAR 299
           IAD    P+ VA DLLSQAEHG DSQ+ILLT +   +M  R+ +A+      L R+   +
Sbjct: 249 IADETCNPESVALDLLSQAEHGLDSQIILLTVSLSPEMFDRIQKAINDHALRLSRSYIIK 308

Query: 300 QALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAG 359
            A+  S ++   ++ Q  E SN YGPEHL++  +NA   +  I +AGSVF+G WSP S G
Sbjct: 309 HAIKKSVIVQVDNVDQAFEWSNLYGPEHLVLHLKNASSYIPKIDNAGSVFVGPWSPVSMG 368

Query: 360 DYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAH 419
           DYASGTNH LPTYGY ++ S +    F K +T QEL++EG   L  T+  LA  E LTAH
Sbjct: 369 DYASGTNHTLPTYGYASSYSGVSTDSFLKYITTQELTEEGIQRLGPTVIRLAELEGLTAH 428

Query: 420 KNAVTLR 426
            +AV +R
Sbjct: 429 ADAVRVR 435


>UniRef50_A9A0A6 Histidinol dehydrogenase n=2 Tax=Desulfobacteraceae
           RepID=A9A0A6_DESOH
          Length = 434

 Score =  522 bits (1345), Expect = e-146,   Method: Composition-based stats.
 Identities = 165/433 (38%), Positives = 249/433 (57%), Gaps = 15/433 (3%)

Query: 9   WNSCTAEQQRQL--LMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV--T 64
           + S T E  R+L  ++   +  +      V  I+ +VK  GD+AL  Y+ +FD   +  +
Sbjct: 4   YTSGTPEADRRLDRIINRGLDYTPEQLHQVAAIVADVKKNGDKALERYTRQFDAPKLAAS 63

Query: 65  ALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPV 124
             +V+A E+A A++ +     +A+  A+  +  FH          E +PGV   +   PV
Sbjct: 64  GFRVTAAEMAGAAKEVDRSFVKAINRAIGQVSEFHAMGLEKTWTAEPRPGVVVGKKVTPV 123

Query: 125 ASVGLYIPG---GSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCG 177
            S G+Y+PG   G  PL STVLM A PA  AG +++V+ +PP     +   +L AA+  G
Sbjct: 124 DSAGIYVPGATGGRTPLVSTVLMGAIPAKTAGVRRIVMVTPPRQDGTVNPHLLVAAKKVG 183

Query: 178 VQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPS 237
           V +++ VG A AIAALA GT+++ +VD I GPGN +V  AK+ V+  +    IDM AGPS
Sbjct: 184 VHEIYKVGSAWAIAALAHGTKTIARVDMIAGPGNIYVALAKKIVAGTV---GIDMMAGPS 240

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAET 297
           E+LV+AD  A P ++A+DLLSQAEH   S  +L+T +  +AR V++ V+RQ   + R + 
Sbjct: 241 EILVVADGSADPRYIAADLLSQAEHDALSAAVLVTTSMKVARAVSDEVKRQTTGISRWQI 300

Query: 298 ARQALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPE 356
           AR+AL     + V K   +   + N++ PEHL + T+N  + +D I +AG+VFLG ++PE
Sbjct: 301 ARKALAAYGAVFVVKSKKEAFALVNRFAPEHLELHTKNPEKDLDQIRNAGAVFLGPYTPE 360

Query: 357 SAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERL 416
             GDY +G NH LPT G     S+L  A F KR ++   SK  F + A+ +  +AA E L
Sbjct: 361 PIGDYVAGPNHTLPTSGCARFASALSTAHFLKRTSIVSYSKAAFLSEAADVMRIAAVEGL 420

Query: 417 TAHKNAVTLRVNA 429
            AH NAV +R+  
Sbjct: 421 DAHANAVGVRLEE 433


>UniRef50_Q87C29 Histidinol dehydrogenase n=66 Tax=cellular organisms
           RepID=HISX_XYLFT
          Length = 431

 Score =  521 bits (1344), Expect = e-146,   Method: Composition-based stats.
 Identities = 216/427 (50%), Positives = 281/427 (65%), Gaps = 5/427 (1%)

Query: 5   TIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVT 64
            IIDWN      Q + L RPA + +      V  +++ V+  GD ALR+ +A+FD   + 
Sbjct: 2   KIIDWNQLDTAAQAKTLTRPAQTIATQTREAVTALIEQVRRGGDTALRDITARFDGVDLA 61

Query: 65  ALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPV 124
             +V+A E+AAA+  ++ EL+ AM  A   IE FH A       VET PGV C+++ RP+
Sbjct: 62  TFEVTAAELAAAATAVAPELQHAMQTAAARIEAFHRAGMTNDYRVETAPGVVCERLVRPI 121

Query: 125 ASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPI----ADEILYAAQLCGVQD 180
           A VGLY+P GSAPLFST LML  PA +AGC++VVLC+PP         +L AA+L GV  
Sbjct: 122 ARVGLYVPAGSAPLFSTALMLGVPARLAGCREVVLCTPPSKDGRANPAVLLAARLTGVTR 181

Query: 181 VFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVL 240
           VF +GGAQAIAA+A+GT SVP  DK+FGPGN+FVTEAK+Q++ +    AIDMPAGPSEVL
Sbjct: 182 VFTLGGAQAIAAMAYGTASVPTCDKVFGPGNSFVTEAKQQLA-QAGVVAIDMPAGPSEVL 240

Query: 241 VIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQ 300
           VIAD+ A P F+A+DLLSQAEHGPDSQV+LL+ +  +   V  A+  QL +L RAE ARQ
Sbjct: 241 VIADAAANPAFIAADLLSQAEHGPDSQVLLLSDSDALMTAVQNALALQLQQLSRAEIARQ 300

Query: 301 ALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGD 360
           AL  SR I    L    +ISN+Y PEHLI+  R  R  +  + +AGSVFLGD++PE+ GD
Sbjct: 301 ALAHSRFIKVATLETAFDISNRYAPEHLILALRQPRAWLHRVAAAGSVFLGDYTPEALGD 360

Query: 361 YASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHK 420
           Y SGTNHVLPT G     S + ++ FQ  ++VQ  S+ G + +     TLA AE L AH 
Sbjct: 361 YCSGTNHVLPTGGAARAYSGVSVSSFQNMISVQAASRSGIAEIGGCALTLARAEGLDAHA 420

Query: 421 NAVTLRV 427
           NAV LR+
Sbjct: 421 NAVALRM 427


>UniRef50_B9KYT3 Histidinol dehydrogenase n=1 Tax=Thermomicrobium roseum DSM 5159
           RepID=B9KYT3_THERP
          Length = 448

 Score =  521 bits (1343), Expect = e-146,   Method: Composition-based stats.
 Identities = 161/403 (39%), Positives = 236/403 (58%), Gaps = 9/403 (2%)

Query: 34  RTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAMAVAVK 93
           + V  I+D+V+++GD+A+R Y+  FD   +     + EE   A   ++ EL+ A+  A  
Sbjct: 48  QVVERIIDDVRSQGDDAVRRYTLAFDGAHLDTFLATPEEFLRARRAITPELEAALRFARD 107

Query: 94  NIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAG 153
            I  FH            + G    Q+ RPV  VG+Y+PGG APL S++LM A PA +AG
Sbjct: 108 RIVAFHRRAIPRSWIEFDETGAF-GQLVRPVDRVGIYVPGGRAPLPSSLLMTAIPAQLAG 166

Query: 154 CKKVVLCSPP----PIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGP 209
            + +V+C+PP     I+  +L AA+L G++ VF +GGAQAIAALA+GT++VP VD + GP
Sbjct: 167 VRDIVVCTPPGRDGTISPAVLAAAELLGIERVFKIGGAQAIAALAYGTQTVPAVDIVAGP 226

Query: 210 GNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVI 269
           GN FV  AKR V   +    ID   GP+E L+IAD  A P   A+DLL+QAEH P +  I
Sbjct: 227 GNLFVVLAKRLVYGDV---GIDQLPGPTETLLIADEQADPVLCAADLLAQAEHDPLACAI 283

Query: 270 LLTPAADMARRVAEAVERQLAELPRAETARQALN-ASRLIVTKDLAQCVEISNQYGPEHL 328
           L+TPA  +A +VA+ +ERQL +L R+E AR AL     +I+  DL +  +++N + PEHL
Sbjct: 284 LITPARTLAHKVAQELERQLQQLDRSEIARAALEANGAIIIVPDLERAFDLANLFAPEHL 343

Query: 329 IIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQK 388
            +  R+    +D +  AG VFLG+ SPE  GDY +G +HV+PT       S + +  F K
Sbjct: 344 CLLVRDPWRYLDRVRHAGGVFLGETSPEVIGDYTAGPSHVMPTGRTARFASPVTVQTFLK 403

Query: 389 RMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNALK 431
             ++  ++ +    L S    LA +E LTAH  A+  R+   +
Sbjct: 404 VTSLVAVAPKALEQLGSPALQLAMSEGLTAHAAAIEHRLERTR 446


>UniRef50_Q3B5E3 Histidinol dehydrogenase n=8 Tax=Chlorobiaceae RepID=HISX_PELLD
          Length = 443

 Score =  520 bits (1340), Expect = e-146,   Method: Composition-based stats.
 Identities = 154/420 (36%), Positives = 229/420 (54%), Gaps = 11/420 (2%)

Query: 18  RQLLMR---PAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIA 74
           R  L R    ++     + R V DIL+ V+ RGD A+ EY+ +F    +T+++V  E+I 
Sbjct: 26  RDALFRQIGRSVDFDPEVQRAVTDILEAVRLRGDMAVLEYTERFQGAVLTSMQVPEEDIL 85

Query: 75  AASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGG 134
            A E       + +  A +NI  FH  +       E + GV   Q   P+    LY+PGG
Sbjct: 86  RAREEADPAFIRVLEEAWENILRFHRHEVENSFFYEGEGGVVLGQRVTPMDRAMLYVPGG 145

Query: 135 SAPLFSTVLMLATPASIAGCKKVVLCSP----PPIADEILYAAQLCGVQDVFNVGGAQAI 190
            A   S+VLM A PA +AG  ++ + +P      ++  IL AA + GV  V+ +GGAQA+
Sbjct: 146 KASYPSSVLMNAAPARVAGVGEIFMTTPCDASGAVSPHILAAASVAGVTSVYRLGGAQAV 205

Query: 191 AALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPD 250
           AA A+GT+++PKVD I GPGN +V  AK+QV   +   AID  AGPSEV+V+AD  A  +
Sbjct: 206 AAFAYGTQTIPKVDIITGPGNKYVALAKKQVFGHV---AIDSIAGPSEVVVVADDDADAE 262

Query: 251 FVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIV 309
           F+  DL +QAEH PD+  +L+TP+  +A  V +    ++  + R E   +AL N   ++V
Sbjct: 263 FITMDLFAQAEHDPDASSVLITPSMRLAEEVRDLAAARVGSMLRGEVIAEALSNNGAIVV 322

Query: 310 TKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVL 369
             D+ +   +S+   PEHL +   +  EL+ SI  AG+VF+G +S E+ GDY +G NH L
Sbjct: 323 VADIEEACRVSDMIAPEHLELHVLHPWELLASIRHAGAVFMGGYSCETVGDYYAGPNHTL 382

Query: 370 PTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNA 429
           PT G     S L + DF K  ++   ++    A    I + A  E L AH  AV  R+  
Sbjct: 383 PTNGTARFFSPLSVRDFVKHTSIISYTRRQIMACGERIASFADHEGLEAHAEAVRARLKK 442


>UniRef50_Q4FQF8 Histidinol dehydrogenase n=6 Tax=Proteobacteria RepID=HISX_PSYA2
          Length = 431

 Score =  520 bits (1340), Expect = e-146,   Method: Composition-based stats.
 Identities = 172/426 (40%), Positives = 244/426 (57%), Gaps = 12/426 (2%)

Query: 10  NSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDK---TTVTAL 66
                + Q   L+        ++  TV+DI+  V+  GD  + E + +FD+   TT  AL
Sbjct: 7   QDADFDSQLTELLAFETVNDATLLTTVDDIIARVRHGGDSVVLELTQQFDQHPATTTQAL 66

Query: 67  KVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVAS 126
           ++S E +A A   L D +K A+  A   ++TFH  Q       E + G R  Q    +  
Sbjct: 67  ELSKEALAEAFANLDDVVKSALITAATRVKTFHERQVQETWQYEDELGNRLGQKVTALDR 126

Query: 127 VGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCGVQDVFN 183
           VG+Y+PGG A   S+VLM A PA +AG K+V++  P P   +   +L AA L  V  VF 
Sbjct: 127 VGIYVPGGLASYPSSVLMNAIPAKVAGVKEVIMVVPAPKGVLNPLVLAAAHLAKVDRVFT 186

Query: 184 VGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIA 243
           +GGAQA+AALA+GTE++P VDKI GPGN +V  AKR V  ++    IDM AGPSEVLV A
Sbjct: 187 IGGAQAVAALAYGTETIPAVDKITGPGNKYVAAAKRAVFGQV---GIDMIAGPSEVLVYA 243

Query: 244 DSGA--TPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQA 301
           +  A    D++A DLLSQAEH   +Q I +T +A   + VA  +E+ LAELP+A+ AR +
Sbjct: 244 EGEAQDRADWLAMDLLSQAEHDRIAQAIFVTTSAQQLKEVAIEIEKALAELPKADIARDS 303

Query: 302 LNA-SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGD 360
           L     LI+ +D  + + + N+  PEHL +   +   L++SI  AG++F+G  +PE+ GD
Sbjct: 304 LKNRGVLILVRDREEGMAVINRVAPEHLELSVDHPDALLNSIRHAGAIFMGRHTPEAIGD 363

Query: 361 YASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHK 420
           Y +G NHVLPT G     S LG+ DFQK+ ++   S+ G   LA T + LA  E L AH 
Sbjct: 364 YCAGPNHVLPTSGTARFSSPLGVYDFQKKSSIIYCSESGSKPLAQTADILAQHEDLEAHA 423

Query: 421 NAVTLR 426
            +   R
Sbjct: 424 RSARYR 429


>UniRef50_C7NG13 Histidinol dehydrogenase n=2 Tax=Bacteria RepID=C7NG13_KYTSD
          Length = 439

 Score =  519 bits (1338), Expect = e-146,   Method: Composition-based stats.
 Identities = 218/433 (50%), Positives = 285/433 (65%), Gaps = 4/433 (0%)

Query: 6   IIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA 65
           ++DWN+    ++   L RPA +  E +T  V ++LD V+ARG +A+  Y+ +FD      
Sbjct: 3   VLDWNALDDSERTAALERPAQAVGEQVTAAVAEVLDAVRARGADAVVGYTERFDGVGREH 62

Query: 66  LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVA 125
           L +S  EI  A E++ D ++ A+A A   + TFH    L P  V+T PG+RC+++ RPV 
Sbjct: 63  LLLSEAEIDRAVEQVPDAVRAAIAQAAATLRTFHAPGALSPFAVDTAPGMRCERIVRPVR 122

Query: 126 SVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPI----ADEILYAAQLCGVQDV 181
           +VGLY+P GSAPL ST LML  PA +AGC +VV+C+PP         ++ A    G++ +
Sbjct: 123 TVGLYVPAGSAPLPSTALMLGVPAVLAGCPEVVVCTPPTAQGTADPSVVAACVEVGIRRI 182

Query: 182 FNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLV 241
             VGGAQA+ A+AFG   +P+ DKIFGPGN+FVTEAKRQV+    G  ID+PAGPSE LV
Sbjct: 183 AVVGGAQAVGAMAFGAGPIPRCDKIFGPGNSFVTEAKRQVAGMQGGPGIDLPAGPSEQLV 242

Query: 242 IADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQA 301
           IAD+GA P +VA+DLLSQAEHGPDSQV+ ++   D+  +VA  VERQ AELPRA+    A
Sbjct: 243 IADAGANPVWVAADLLSQAEHGPDSQVVCVSDDRDLLEQVAAEVERQAAELPRAQIVAGA 302

Query: 302 LNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDY 361
           L ASRL++  DL Q V +SN Y PEHLI+  R  REL+  IT+AGS+FLGD +PES GDY
Sbjct: 303 LTASRLVLVDDLDQAVAVSNAYAPEHLILAVRAPRELLAGITAAGSIFLGDHTPESLGDY 362

Query: 362 ASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKN 421
            SGTNHVLPT G       + LA FQ  +TVQE S    + L +T  TLA AE L AH  
Sbjct: 363 CSGTNHVLPTSGAARYTGGVNLASFQLSITVQEASPRALAQLGATAVTLARAEGLEAHAR 422

Query: 422 AVTLRVNALKEQA 434
           AVT RV+A +  A
Sbjct: 423 AVTRRVDASEAAA 435


>UniRef50_Q3ZXL7 Histidinol dehydrogenase n=5 Tax=Dehalococcoides RepID=HISX_DEHSC
          Length = 436

 Score =  518 bits (1334), Expect = e-145,   Method: Composition-based stats.
 Identities = 160/422 (37%), Positives = 243/422 (57%), Gaps = 14/422 (3%)

Query: 12  CTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAE 71
               ++ +L  R  +       + VN I+ +V+ +GDEA+  Y+ KFD+  ++ L+V   
Sbjct: 24  LDETERTELARRLGVDP----EKAVNGIIADVRKQGDEAVLGYTLKFDRANLSKLEVGQP 79

Query: 72  EIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYI 131
           EI  A+  +  EL +A+ +A   I  +H  QK      +T   ++ +Q+ RP+  VGLY+
Sbjct: 80  EIQQAASEIPAELFEALQLAASQIRAYHRFQKEAVW--KTAEIMQGKQLIRPLERVGLYV 137

Query: 132 PGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEI----LYAAQLCGVQDVFNVGGA 187
           PGG A   STVLM A PA  AG K+++L +PP    +I    L AAQ+ GV  +F  GGA
Sbjct: 138 PGGKAFYPSTVLMTAIPAREAGVKEIILVTPPGANGKIPAPTLAAAQIAGVDRIFACGGA 197

Query: 188 QAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGA 247
           QA+AALAFGT+S+PKVDKI GPGN FVT AK+ V   +D   ID   GPSEVL++AD  A
Sbjct: 198 QAVAALAFGTKSIPKVDKICGPGNIFVTLAKKAVFGVVD---IDGLQGPSEVLIVADQYA 254

Query: 248 TPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRL 307
             ++ ASD+L+QAEH   +  IL+T + D+A RV + VE +     R +  +Q+L  + L
Sbjct: 255 NAEYCASDILAQAEHDALASSILITTSEDLANRVNDIVESKADTCSRRDIIKQSLRDNGL 314

Query: 308 I-VTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTN 366
           I V  ++ + ++++N Y  EHL +  +++ + +  I  AG +F G+ +    GDY +G +
Sbjct: 315 IAVVDNINEAIKLANMYAAEHLCLLVKDSEKYLTQINHAGCIFYGEKASVVMGDYVAGPS 374

Query: 367 HVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
           H LPT G     S L + DF K + + ++ K+  + L     T+A AE L  H  AV  R
Sbjct: 375 HALPTSGTARFSSPLNILDFVKYIDIVKVDKQDIAKLGQAAATIAKAEGLECHAEAVLKR 434

Query: 427 VN 428
           + 
Sbjct: 435 LE 436


>UniRef50_Q9X0D1 Histidinol dehydrogenase n=6 Tax=Thermotogaceae RepID=HISX_THEMA
          Length = 428

 Score =  517 bits (1333), Expect = e-145,   Method: Composition-based stats.
 Identities = 150/419 (35%), Positives = 243/419 (57%), Gaps = 14/419 (3%)

Query: 21  LMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDK--TTVTALKVSAEEIAAASE 78
           L++  + +   +  TV +I+  VK  GD AL E+  +F+K    +  L+V+ +EI+ A  
Sbjct: 15  LLKQRMESVSQVEETVKEIIRRVKEEGDRALEEFLKRFEKHPVGIENLRVTEKEISEA-- 72

Query: 79  RLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPL 138
           ++ +E  + + + +++++ FH  Q+       T+ G    ++  P+ SVG+Y+PGG  P 
Sbjct: 73  QVEEEFVETIKIVIEDLKEFHRRQEERSFFFTTKGGSFLGEMVVPLESVGIYVPGGKVPY 132

Query: 139 FSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQDVFNVGGAQAIAALA 194
           FST+LM A PA +AG +++ + +PP     I+  IL   ++ G+++++ +GGA A+AAL 
Sbjct: 133 FSTLLMCAVPAIVAGVERIAVTTPPNENGGISPYILKTCEILGLKEIYRMGGAHAVAALT 192

Query: 195 FGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVAS 254
           +GTE+V  VDKI GPG  FVT AK+ V   +    ID  AGPSE+ ++ D  A  D +A+
Sbjct: 193 YGTETVKPVDKIVGPGGVFVTLAKKHVYGDV---GIDSIAGPSEIAIVTDGSADLDLIAA 249

Query: 255 DLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELP--RAETARQALNA-SRLIVTK 311
           D LSQAEH  ++  +++T + ++  ++ + +ER L  LP  R +TAR +      +I+T 
Sbjct: 250 DFLSQAEHDENAMSVVITTSKEVFEKLPQVIERHLEALPEERRKTARISTENFGTIILTD 309

Query: 312 DLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPT 371
            L +  EISN   PEHL +   N  E +  I +AGSVFLG ++ ES GDY +G NHVLPT
Sbjct: 310 SLKRAFEISNLIAPEHLEVLVENPFEPLGHIKNAGSVFLGKYTCESVGDYGAGPNHVLPT 369

Query: 372 YGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNAL 430
           +      S L ++DF K++ +  LS+E F   +     +A  E   AH  A+ +R   L
Sbjct: 370 FRSARFSSGLRVSDFTKKIFITHLSEEDFRRKSELYSKMARWEGFEAHARAIDVRREKL 428


>UniRef50_A5D1M4 Histidinol dehydrogenase n=1 Tax=Pelotomaculum thermopropionicum SI
           RepID=A5D1M4_PELTS
          Length = 437

 Score =  511 bits (1317), Expect = e-143,   Method: Composition-based stats.
 Identities = 154/440 (35%), Positives = 241/440 (54%), Gaps = 14/440 (3%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
           +  +      +AE   +++ R  +  ++S+   V  ++ +VK+RGD+AL +Y+ +FD  T
Sbjct: 2   YIQVFRLKEMSAEDYNRIMKRSEVE-TDSVIGEVKKVIADVKSRGDDALVDYTREFDGIT 60

Query: 63  VTA--LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPP-VDVETQPGVRCQQ 119
           ++A  ++VS EEI  A  ++  E  +A+     N+  FH AQ       +E  PG+   Q
Sbjct: 61  ISAEKIRVSPEEIKEAYHKVDRETVEAIKTLAGNVRRFHAAQMPNKMWSMEVSPGLVAGQ 120

Query: 120 VTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSP----PPIADEILYAAQL 175
           V  P+  VG Y+PGG     S V+M   PA +AG  +V++C+P      +    L A  +
Sbjct: 121 VIIPLDRVGCYVPGGRGWFPSAVMMSVLPARVAGVPEVIVCTPSAPDGSVPPGTLVACDI 180

Query: 176 CGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAG 235
           CG   VF +GG+QA+AA+A+GT++VPKVDKI GPG+ +V  A + +   ++   I   AG
Sbjct: 181 CGADAVFRIGGSQAVAAMAYGTQTVPKVDKIVGPGSKWVLAAFKLLYGEVE---IGTHAG 237

Query: 236 PSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELP-- 293
           P E L+IAD  A P+F A+D+  QAEHG DS  +L+T   ++A  V + + R +  L   
Sbjct: 238 PGEGLIIADETADPEFAAADICIQAEHGLDSAGVLVTHVEELAWAVQKKIARHIERLNEY 297

Query: 294 RAETARQALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGD 352
           R     ++L     +I+T  L + +  +N Y  EHL I TR+   ++  I +AG ++LG 
Sbjct: 298 RKNFVVESLKKYGAIIITSSLEESIAFANDYAVEHLEIMTRDPLHVMQKIKNAGGIYLGH 357

Query: 353 WSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAA 412
           ++P S G + SG NHVLPT         L  ADF K +T + LS+EG ++L   +  LA 
Sbjct: 358 YTPLSCGCFGSGPNHVLPTGRKAKVSGGLKTADFYKAVTFEYLSREGLASLKDAMVKLAE 417

Query: 413 AERLTAHKNAVTLRVNALKE 432
            E   AH NA+  R    + 
Sbjct: 418 YEGFPAHGNAILERFAREQS 437


>UniRef50_B3DXR9 Histidinol dehydrogenase n=1 Tax=Methylacidiphilum infernorum V4
           RepID=B3DXR9_METI4
          Length = 426

 Score =  510 bits (1314), Expect = e-143,   Method: Composition-based stats.
 Identities = 150/430 (34%), Positives = 251/430 (58%), Gaps = 8/430 (1%)

Query: 1   MSFNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDK 60
           M    I+ +     +Q+++ L R  +  S+ I +TV  +L+ +   GD+A+  Y+ +FDK
Sbjct: 3   MIDFKILRFGDLNWQQEKKGLSRFYLP-SKEIEQTVRRVLEEIIRNGDKAVSLYTEQFDK 61

Query: 61  TTVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQV 120
            +++     A  I   + +   ++  A+  A +NI  F  A K     +  + G R  + 
Sbjct: 62  QSISP---GAFRITEKAPQPPKDVVDALRWAKRNILCFAKANKPKNWSITNREGARVGEY 118

Query: 121 TRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQD 180
             P   +G+Y+PGG+APL ST LM    A  AG K++V+CSPPP+   + ++    G  +
Sbjct: 119 YTPFRRIGVYVPGGTAPLISTALMTVCFAKAAGVKEIVVCSPPPVNPILHFSIIYSGATE 178

Query: 181 VFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVL 240
           ++ +GG QAI ALA+GTES+PKV+KIFGPGNA+V EAKRQV   +   +ID+  GPSE+ 
Sbjct: 179 IYRIGGIQAIGALAYGTESIPKVEKIFGPGNAYVVEAKRQV---IGPVSIDLLPGPSEIA 235

Query: 241 VIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQ 300
           V A   A P+F+A+DLL+QAEHGP S+++ ++P   +   V  A+ RQL  L R +  ++
Sbjct: 236 VFASWPANPEFIAADLLAQAEHGPSSKILFVSPENSLLESVIGAINRQLPSLKRQQILKE 295

Query: 301 AL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAG 359
            L + +  +  + + + + + N + PEHL +Q   A++ +    + G+++LG +S  +AG
Sbjct: 296 VLTDHAYFVQVRSIDEGIGLINDFAPEHLSLQIPGAKKYLAQFKNCGAIYLGPYSAVAAG 355

Query: 360 DYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAH 419
           D+ +G +H LPT G   + S L ++ F ++ +V E SK+    ++S +ET A  E L AH
Sbjct: 356 DFLAGPSHTLPTGGAAKSFSGLTMSHFYRKTSVVEYSKKALCRVSSLLETFARIESLDAH 415

Query: 420 KNAVTLRVNA 429
             ++T+R  +
Sbjct: 416 GASITIRKES 425


>UniRef50_Q01ZU1 Histidinol dehydrogenase n=1 Tax=Candidatus Solibacter usitatus
           Ellin6076 RepID=Q01ZU1_SOLUE
          Length = 423

 Score =  508 bits (1310), Expect = e-142,   Method: Composition-based stats.
 Identities = 168/417 (40%), Positives = 247/417 (59%), Gaps = 10/417 (2%)

Query: 12  CTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAE 71
             ++    LL R A   +E+    V  IL+ V+ RGD AL +Y+ +FD+    +++V   
Sbjct: 5   LESKDVGHLLKRKAARFTEA-EAVVTPILEAVRKRGDRALMDYARQFDQLQRKSVRVPEG 63

Query: 72  EIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYI 131
           E+ AA + L+ E + A+  A  NI  +   Q     +     G++  Q+ RP+ +V  YI
Sbjct: 64  ELLAARDGLTPEFRGAIETAAPNIRAYAGRQMPREWNRSFGAGLQLGQLVRPLDAVAAYI 123

Query: 132 PGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVFNVGGAQAIA 191
           P G  PL STV+M   PA +AG   + +  P P+A E+   A + GV++VF +GGAQAIA
Sbjct: 124 PAGRYPLPSTVMMTVIPAQVAGVPNICIACPKPVA-EVYGTAAMLGVRNVFQMGGAQAIA 182

Query: 192 ALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDF 251
           A AFGT +VP+ D+I GPGN +V  AK+ ++  +    ID  AGP+E+L+IA  G  P  
Sbjct: 183 AFAFGTRTVPRADRIVGPGNIYVAAAKKLLAGEV---GIDFIAGPTEILIIAADG-DPRH 238

Query: 252 VASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVT 310
            A+D+L+QAEH  D+  ILLT +  +A  V+  +ERQLA LP A  A +++   S +I+ 
Sbjct: 239 FAADMLAQAEHDVDASAILLTTSKRLAAAVSRELERQLAILPTAPVASKSIAKNSAIILV 298

Query: 311 KDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLP 370
           + L + +EISN++ PEHL I       L+  +  AGSVF+G +SPE+AGDYASG NHVLP
Sbjct: 299 RSLDEALEISNRFAPEHLSIPDA---SLLPGVRHAGSVFVGPYSPEAAGDYASGPNHVLP 355

Query: 371 TYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRV 427
           T G       L + D+ K ++VQ L++     LA +I TLA AE L AH  +V +R+
Sbjct: 356 TSGAARQRGGLSVTDYVKVISVQNLTEPALRRLAPSITTLARAEGLEAHARSVEVRL 412


>UniRef50_A3EUM9 Histidinol dehydrogenase n=3 Tax=Leptospirillum RepID=A3EUM9_9BACT
          Length = 445

 Score =  508 bits (1308), Expect = e-142,   Method: Composition-based stats.
 Identities = 156/422 (36%), Positives = 239/422 (56%), Gaps = 11/422 (2%)

Query: 20  LLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT--VTALKVSAEEIAAAS 77
           +  R   S  E++   V+ IL +++  GD AL  Y+ + D     +  L+VS   +  + 
Sbjct: 24  IFQRGRDSEGETLRARVSSILGDIRREGDVALLRYARELDGFRGELKDLRVSPGRMEESF 83

Query: 78  ERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAP 137
             L  E+++A+  A   IE FH A +   +        +   + RP+  VG+Y+PGG+A 
Sbjct: 84  GALPSEIRKALVFAKDRIEEFHGALREKGLSGLASRPGKGGVLVRPLHRVGVYVPGGTAA 143

Query: 138 LFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCGVQDVFNVGGAQAIAALA 194
             STVLM A  A +AG K++V  SP     I D IL A  +CGVQDV+ VGG  AIAA+A
Sbjct: 144 YPSTVLMTAVVAKVAGVKQIVGVSPAGPGGIPDAILAAFHVCGVQDVYQVGGVHAIAAMA 203

Query: 195 FGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVAS 254
           +GT ++P+VDKI GPGN +V EAKRQV   +D   IDM AGP+E+L++AD  A P+++A+
Sbjct: 204 YGTGTIPRVDKIVGPGNRYVAEAKRQVFGDVD---IDMVAGPTEILILADDSARPEWLAA 260

Query: 255 DLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDL 313
           D+++QAEH   +  +L+     +A+ V  A+ERQ++ LPR + A ++L     ++V   +
Sbjct: 261 DMIAQAEHDTRASAVLILTDMTLAKAVVLALERQISSLPRQKIAEESLLKYGFILVVPSV 320

Query: 314 AQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYG 373
              VEIS+   PEHL +Q RN  + +  I +AG+VFLG    E+ GDY  G +HVLPT G
Sbjct: 321 QVAVEISDLVAPEHLELQVRNPEKWLGLIQNAGAVFLGSEMAEAFGDYCFGPSHVLPTNG 380

Query: 374 YTATCSSLGLADFQKRMTVQE--LSKEGFSALASTIETLAAAERLTAHKNAVTLRVNALK 431
                S + +  F KR ++ E   S++    +      LA  E L  H  +   R+  ++
Sbjct: 381 SARFSSPVSIETFTKRTSLLEGFRSRQELEDVVRNSALLARLEGLEGHARSALARLENVQ 440

Query: 432 EQ 433
           ++
Sbjct: 441 KE 442


>UniRef50_C9RN89 Histidinol dehydrogenase n=1 Tax=Fibrobacter succinogenes subsp.
           succinogenes S85 RepID=C9RN89_FIBSS
          Length = 429

 Score =  504 bits (1298), Expect = e-141,   Method: Composition-based stats.
 Identities = 164/424 (38%), Positives = 239/424 (56%), Gaps = 14/424 (3%)

Query: 14  AEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEI 73
           +++  ++  R  ++ S+ I   V DIL ++K  G     EY+ KFD      L+VS  EI
Sbjct: 10  SQEIDRICGR-EVAPSKEIHDKVMDILADIKNGGYAKAVEYAQKFDGLKGKNLRVSEAEI 68

Query: 74  AAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPG 133
             ++ +   E+++A+  A+KN+  FH  Q      +E + GV   Q  RP+  VGLY+PG
Sbjct: 69  KKSAAKCPPEMQRALKQAIKNVRDFHVNQMEDSWLMEGKDGVVLGQRIRPMKRVGLYVPG 128

Query: 134 GSAPLFSTVLMLATPASIAGCKKVVLCSP--PPIADEILYAAQLCGVQDVFNVGGAQAIA 191
           G+    STV+M A PA +AG K +V+ +P    I   + +     G+ +V+++GGAQAI 
Sbjct: 129 GAGIYPSTVIMNAVPAIVAGVKDIVVVTPIKGEINRAVAFVLCELGITEVYHIGGAQAIG 188

Query: 192 ALAFGTES------VPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADS 245
            LA+G +       V +VDKI GPGN F   AK++V   +D   IDM AGPSEVLV+AD+
Sbjct: 189 MLAYGAKDGKGKVVVERVDKIVGPGNVFAAVAKKEVFGIVD---IDMVAGPSEVLVLADN 245

Query: 246 GATPDFVASDLLSQAEHGPD-SQVILLTPAADMARRVAEAVERQLAELPRAETARQALNA 304
              PDFVA+DLLSQAEHG      I +T   + A+ ++E V+ Q+   P+ E  ++ L+ 
Sbjct: 246 TCDPDFVAADLLSQAEHGSGFEAAICITDNMETAQMISECVDIQVENSPKRELLQKVLDN 305

Query: 305 -SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYAS 363
             R++V KD    V I+N   PEH+ I T  A  +   I +AG+VF+G WS E  GDY +
Sbjct: 306 FGRILVVKDWFDGVAIANAIAPEHMEIMTDEAESMAAQIENAGAVFIGPWSSEPVGDYFA 365

Query: 364 GTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAV 423
           G NHVLPT G     S LG+ DF KRM++ + S++     A  I  +A  E    H  AV
Sbjct: 366 GPNHVLPTNGTGRFFSPLGVYDFLKRMSIIKYSEKAIKKNAKAIAVVANEEGFIHHAAAV 425

Query: 424 TLRV 427
             R+
Sbjct: 426 LKRL 429


>UniRef50_P62460 Histidinol dehydrogenase n=15 Tax=Bacteria RepID=HISX_THET2
          Length = 412

 Score =  504 bits (1298), Expect = e-141,   Method: Composition-based stats.
 Identities = 172/413 (41%), Positives = 241/413 (58%), Gaps = 6/413 (1%)

Query: 14  AEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEI 73
           AE+ R    R  +S   ++   V  IL+ V+  GDEAL  +S   D   V   +V     
Sbjct: 5   AEEVRARFARRGLSFDPTVEEIVRGILEAVREEGDEALDRFSRDLDGYPVE--EVPKRAW 62

Query: 74  AAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPG 133
             A E L ++L+ A+  A + IE F+  +      +  + G    Q+ RP+  VG+Y+PG
Sbjct: 63  REAYEDLDEDLRDALETARERIEAFYREEARGGF-LRAEGGGVLAQLVRPLERVGVYVPG 121

Query: 134 GSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVFNVGGAQAIAAL 193
           GSAPL ST+LM   PA +AG ++V++ SPP +   +L AA + G   +F +GGAQAIAAL
Sbjct: 122 GSAPLLSTLLMTVVPAKVAGVREVIVASPPKVHPGVLAAAWVAGADRLFAMGGAQAIAAL 181

Query: 194 AFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVA 253
           A+GT  VP+VDKI GPGN +V  AKR V   +    ID  AGP+E ++IAD  A+P  +A
Sbjct: 182 AYGTGRVPRVDKIVGPGNRYVVAAKRLVYGTV---GIDGLAGPTETMIIADGSASPRLLA 238

Query: 254 SDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDL 313
           +DLL+QAEHGPDS+  LL+P   +  RV   + RQL +LPRAE ARQAL    L++TKDL
Sbjct: 239 ADLLAQAEHGPDSEPWLLSPDRALLERVEAELSRQLQDLPRAEVARQALEKGGLVLTKDL 298

Query: 314 AQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYG 373
            +   ++N Y PEHL +   +    ++ + +AG VFLG+ SPE+ GDY +G +HV+PT G
Sbjct: 299 EEAFALANLYAPEHLSLALSDPLPWLEKVQNAGGVFLGEGSPEALGDYIAGPSHVMPTSG 358

Query: 374 YTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
                  L + DF K + V  LS+     LA     LA AE L  H  ++ LR
Sbjct: 359 TARFQGGLAVRDFLKVIPVVGLSEGAARELAKKGALLARAEGLEGHARSLDLR 411


>UniRef50_C8WUX6 Histidinol dehydrogenase n=2 Tax=Alicyclobacillus acidocaldarius
           RepID=C8WUX6_ALIAD
          Length = 426

 Score =  503 bits (1296), Expect = e-141,   Method: Composition-based stats.
 Identities = 171/421 (40%), Positives = 243/421 (57%), Gaps = 9/421 (2%)

Query: 16  QQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAA 75
           +Q     R        +   V  I++ V+  GD+ALR  +   D      L+V  E + A
Sbjct: 10  EQASFNWRRTTGRDADVWEKVERIVEEVRVGGDDALRRLTRALDGVD-APLRVPPEAMEA 68

Query: 76  ASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGS 135
           A   L  E+++A+A A + I  FH AQ    + +  + G   + + RP+  VG+Y PGG 
Sbjct: 69  AFRALRAEVREALARAAERIRRFHEAQLPNDIVIRGEDGETLEMLWRPLHRVGVYAPGGR 128

Query: 136 APLFSTVLMLATPASIAGCKKVVLCSPPPI----ADEILYAAQLCGVQDVFNVGGAQAIA 191
           A   STVLM   PA +AG + + L SPP         +L AA L GV++++ VGGAQA+A
Sbjct: 129 AAYPSTVLMDVIPAQVAGVRSIALVSPPGPDGLPHPAVLAAAHLVGVEEMYAVGGAQAVA 188

Query: 192 ALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDF 251
           ALA+GTE++ +VDKI GPGN +V  AKR V   +    ID  AGP+EV+V+AD  A P +
Sbjct: 189 ALAYGTETIARVDKIVGPGNVYVATAKRMVMGDV---GIDSIAGPTEVVVVADETANPAY 245

Query: 252 VASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALN-ASRLIVT 310
           VA+DLL+QAEH  ++  + L+P+ ++   V   + RQLA LPR + AR+AL     L+  
Sbjct: 246 VAADLLAQAEHDVEAGAVCLSPSRELLENVHAEIVRQLAALPRRDIAREALERHGALVHV 305

Query: 311 KDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLP 370
           K L   V + N   PEH+ + T N R +++ + +AG+VFLG ++PE  GDY +GTNHVLP
Sbjct: 306 KSLDDAVVLVNDMAPEHVEVVTENPRRVLNGLRTAGAVFLGPYTPEPVGDYFAGTNHVLP 365

Query: 371 TYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNAL 430
           T+G     S LG  DF +RMT    + E  +  A  IE LA AE LTAH+ AV +R   L
Sbjct: 366 THGSARFSSGLGTLDFMRRMTAATYTAETIARHAPYIEALAEAESLTAHREAVRIRREEL 425

Query: 431 K 431
           +
Sbjct: 426 R 426


>UniRef50_D0LM64 Histidinol dehydrogenase n=2 Tax=Nannocystineae RepID=D0LM64_HALO1
          Length = 438

 Score =  502 bits (1293), Expect = e-140,   Method: Composition-based stats.
 Identities = 180/426 (42%), Positives = 255/426 (59%), Gaps = 12/426 (2%)

Query: 13  TAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV---TALKVS 69
            + + R LL R + S +  + R V DIL  V+ARGDEA+R ++ KFD  +    ++ ++ 
Sbjct: 13  DSRELRALLER-STSFASEVERAVADILAEVRARGDEAVRAFTEKFDGRSPRAGSSYEIP 71

Query: 70  AEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVE---TQPGVRCQQVTRPVAS 126
             +   A   L+ E+  A+  A + +  FH  Q       +      G+R      P++ 
Sbjct: 72  PGDWRRAKGELAPEVLAALEQAAERVRAFHARQAEVDRAADFSLDGGGMRLDLRIDPLSR 131

Query: 127 VGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVFNVGG 186
           VG+Y+PGG+A   S+VLM A PA IAG  ++++ +P   + E L AA L GV  VF +GG
Sbjct: 132 VGIYVPGGTARYPSSVLMTAIPARIAGVDEIIMVTP-GASKETLAAAALAGVDRVFEIGG 190

Query: 187 AQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSG 246
           AQA+AALA+GTESVP+VDKI GPGN +V  AKRQV   +D   ID  AGPSEVL++AD  
Sbjct: 191 AQAVAALAYGTESVPRVDKIVGPGNQWVAAAKRQVFGVVD---IDSVAGPSEVLILADDS 247

Query: 247 ATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NAS 305
           A P +VA+DLL+QAEH P +  +L T +  +A  V E + RQLA+LPRA+ AR AL N  
Sbjct: 248 ANPRWVAADLLAQAEHDPLAHPVLATTSPALADAVDEELARQLADLPRADIARTALANQG 307

Query: 306 RLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGT 365
             ++  D    V  +N+Y PEHL +  R  R ++  + +AG++F+G  + E+AGDY +G 
Sbjct: 308 AAVLVPDQGAAVAFANRYAPEHLELHLREPRAVLGQLRTAGAIFVGALAAEAAGDYMAGP 367

Query: 366 NHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTL 425
           NHVLPT G     S LG+ DF+K  ++ E   E   A A  I  LAA E L AH  ++TL
Sbjct: 368 NHVLPTGGAARYASPLGVYDFRKHTSIIEYQAEAVLAQADAIAALAAVEGLDAHGRSMTL 427

Query: 426 RVNALK 431
           R +AL+
Sbjct: 428 RRDALR 433


>UniRef50_B1YL14 Histidinol dehydrogenase n=1 Tax=Exiguobacterium sibiricum 255-15
           RepID=B1YL14_EXIS2
          Length = 405

 Score =  498 bits (1283), Expect = e-139,   Method: Composition-based stats.
 Identities = 162/403 (40%), Positives = 236/403 (58%), Gaps = 6/403 (1%)

Query: 27  SASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQ 86
           S      + V  IL+ V   GD A+R Y+++FD+  +T  ++   +I  A ++    L  
Sbjct: 8   SVDRETEQAVRSILEQVANDGDAAVRRYTSEFDRVDLTDFRLDETKIQEAFDQADPNLVD 67

Query: 87  AMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLA 146
           ++ +    +  +H  +    +++     V  +Q   PV SVG+Y+PGG+A   STVLM A
Sbjct: 68  SLKLMATRLVEWHEQELPSDIELVEAD-VTRRQRFVPVDSVGIYVPGGAASYPSTVLMNA 126

Query: 147 TPASIAGCKKVVLCSP-PPIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDK 205
            PA +AG ++VV+ +P   ++ E+L AA++ GV +++ +GGAQA+AAL FGTES+  VD 
Sbjct: 127 IPAKVAGVERVVMVTPVTGLSMEVLVAAKIAGVTEIYTIGGAQAVAALTFGTESIQAVDL 186

Query: 206 IFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPD 265
           I GPGN FV EAKRQV   +    ID  AGPSEV+VIAD  A PD +A+DLL+QAEH  D
Sbjct: 187 IVGPGNRFVAEAKRQVYGIV---GIDSVAGPSEVVVIADETAHPDRIAADLLAQAEHDRD 243

Query: 266 SQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQCVEISNQYGP 325
           +  I   P   M   V   +ER+L +LPR E AR+A+    + V   L   +E +N+   
Sbjct: 244 AVAIAFVPTEAMKADVDANIERRLQQLPRQEIARRAMENGGVFVA-SLDDAIEEANRLAA 302

Query: 326 EHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLAD 385
           EHL +   N +E+V  I  AG +FLG  +PE+ GDY +GTNHVLPT G     S L    
Sbjct: 303 EHLELAVANPQEVVKLIRHAGMIFLGHETPETLGDYVAGTNHVLPTSGTARFASGLSART 362

Query: 386 FQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVN 428
           F +  T+ E ++EG + LA+  +T+A  E L AH  A+ +R N
Sbjct: 363 FLRHQTMLEATREGVARLANAAKTVARVEGLEAHAQAIEVREN 405


>UniRef50_Q4A044 Histidinol dehydrogenase n=62 Tax=Staphylococcus RepID=HISX_STAS1
          Length = 423

 Score =  496 bits (1279), Expect = e-139,   Method: Composition-based stats.
 Identities = 144/419 (34%), Positives = 239/419 (57%), Gaps = 14/419 (3%)

Query: 18  RQLLMRPAISAS---ESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIA 74
           + L ++  ++ S   E +   V DI +NV+  GD+ALR Y+ +FD+     L+V+ + + 
Sbjct: 5   KTLFLKKYLNQSSLNEDLYPIVKDICENVRLHGDDALRNYNQQFDQVETCNLEVAYQTLE 64

Query: 75  AASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGG 134
            A  RL  +L++A+  +   I+++  + K      + Q    C ++  P+  VG+Y+PGG
Sbjct: 65  NAYNRLDSDLREALQQSHARIQSYQESIK----WTKQQGTSDCYELYHPLERVGVYVPGG 120

Query: 135 SAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCGVQDVFNVGGAQAIA 191
            A   STVLM  T A +AG K + + +PP    I D +L A  + GV +V+ VGGAQ+IA
Sbjct: 121 KASYPSTVLMTVTLAKVAGVKNISVVTPPQLNGIPDIVLAACYIAGVDNVYQVGGAQSIA 180

Query: 192 ALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDF 251
           ALA+GTE++PKVDKI GPGN FV  AK+ +  ++    ID  AGPSE+ +I D  A  D 
Sbjct: 181 ALAYGTETLPKVDKIVGPGNQFVAYAKKYLFGQV---GIDQIAGPSEIALIIDDSADLDA 237

Query: 252 VASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALN-ASRLIVT 310
           +A D+ +QAEH   ++  +++    + +++ + ++  L ++ R    + +LN    LI  
Sbjct: 238 IAYDVFAQAEHDELARTFVISEDEALLKQLEQKIQHILPQIERQSIVQASLNDNHFLIHV 297

Query: 311 KDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLP 370
            + ++  ++ NQ  PEH  IQT +  + ++ +   G++FLG +SPE  GDY +G +HVLP
Sbjct: 298 NNFSEACDLMNQIAPEHASIQTVSPHDYLNHVRYVGALFLGYYSPEVIGDYVAGPSHVLP 357

Query: 371 TYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNA 429
           T       + L + DF  R +V +LSK+ F  +  T   LA  E+L  H+ ++ +R + 
Sbjct: 358 TNQTARFTNGLSVNDFLTRHSVIDLSKDTFDTVELTARKLAHVEQLYNHEQSIEIRTSK 416


>UniRef50_UPI00016BFCCC histidinol dehydrogenase n=1 Tax=Epulopiscium sp. 'N.t. morphotype
           B' RepID=UPI00016BFCCC
          Length = 419

 Score =  495 bits (1276), Expect = e-138,   Method: Composition-based stats.
 Identities = 170/413 (41%), Positives = 241/413 (58%), Gaps = 9/413 (2%)

Query: 21  LMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERL 80
           +++ +   S  I R   +I++ VK  GD+AL +Y+ KFD+  +T+L VS +E+  A E +
Sbjct: 11  ILKHSAEISPQIERDAQEIVETVKRLGDQALFDYALKFDRAQLTSLLVSEQELKDAYEXI 70

Query: 81  SDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFS 140
            D+L   +  A KNIE FH  Q      VE + G+   Q   P+  VG+YIPGG A   S
Sbjct: 71  DDDLLGVIRRAKKNIEDFHKRQITNSFMVE-KDGIIMGQRVTPIERVGIYIPGGXAVYPS 129

Query: 141 TVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQDVFNVGGAQAIAALAFG 196
           +VLM   PA +AGC  + + +PP     +A EIL    + GV  VF +GGA AIAALA+G
Sbjct: 130 SVLMNVIPAKLAGCSYISVVTPPREDGTVAKEILAICAMLGVDQVFKIGGAGAIAALAYG 189

Query: 197 TESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDL 256
           TESV  V KI GPGNA+V  AK+ V  ++    IDM AGPSE+L+IAD    P  +A+D+
Sbjct: 190 TESVLPVYKITGPGNAYVAAAKKAVFGKV---GIDMIAGPSEILIIADEKQXPKIIAADM 246

Query: 257 LSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALN-ASRLIVTKDLAQ 315
           LSQAEH   ++ ILLT + ++A  VA  +E QL++LP+ + AR +++    ++V   L++
Sbjct: 247 LSQAEHDMLARAILLTTSKEIAEEVATEIEIQLSKLPKEKIARPSIDDNGLIVVCDTLSE 306

Query: 316 CVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYT 375
           C  ISN   PEHL I   NA   +  I +AGSVFLG ++PE+ GDY +G NH LPT   +
Sbjct: 307 CFAISNDLAPEHLEIMLDNAISYLPEIKNAGSVFLGRYTPEAVGDYYAGVNHTLPTNQTS 366

Query: 376 ATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVN 428
              S+L +  F K+ T  + ++E        I   A  E L AH  +V  R  
Sbjct: 367 KFSSALSVDTFVKKSTFVQYTEEMLQKYKDDIVLFAKHEGLDAHARSVQSRFQ 419


>UniRef50_C4L171 Histidinol dehydrogenase n=1 Tax=Exiguobacterium sp. AT1b
           RepID=C4L171_EXISA
          Length = 405

 Score =  494 bits (1272), Expect = e-138,   Method: Composition-based stats.
 Identities = 148/405 (36%), Positives = 237/405 (58%), Gaps = 14/405 (3%)

Query: 30  ESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLS-DELKQAM 88
           E+    V  I+++++ARGDEAL +++ +FD       ++ + ++A+ +  ++  EL +A+
Sbjct: 11  EAWAEAVKPIVESIEARGDEALLKWTKQFDGVD----RIESVDLASFNPPVAYAELTEAL 66

Query: 89  AVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATP 148
           ++A + I TFH  Q       E     R  +   P+ SVG+Y+PGG+A   S+VLM   P
Sbjct: 67  SLAAERIRTFHARQVRQDDVFEDT-MFRLGRRYMPLDSVGVYVPGGTAVYPSSVLMNIIP 125

Query: 149 ASIAGCKKVVLCSPPP---IADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDK 205
           A +AG K+VV+ +PP    I   +L AA++ G  + F +GGAQA+AALA+GTE++  VDK
Sbjct: 126 AKVAGVKRVVMVTPPKADGIDISLLIAAKIAGADECFLIGGAQAVAALAYGTETIRPVDK 185

Query: 206 IFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPD 265
           I GPGNA+V  AK  VS  +    ID  AGPSEVL+IAD  A P +VA+DLL+QAEH  +
Sbjct: 186 IVGPGNAYVATAKALVSHIV---GIDSVAGPSEVLIIADETANPKWVAADLLAQAEHDVE 242

Query: 266 SQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQCVEISNQYGP 325
           +  I +  +  +  ++ + +ERQL +LPR + AR++L     ++ + +   +E +N    
Sbjct: 243 ATAIAIVTSETLRDQIEQELERQLVQLPRQDIARESLKRGG-VLYRTIEDAIEYANTMAA 301

Query: 326 EHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLAD 385
           EH+ +  ++   L+ +I   GS FLG  + E+ GDY +G NHVLPT G     S L + D
Sbjct: 302 EHVQLAVKDPEVLMRAIRHGGSFFLGHEAAEAFGDYIAGPNHVLPTSGTARFSSGLSVDD 361

Query: 386 FQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNAL 430
           F +R T  E+++     +      +A  E+L  H  A+ +R+  +
Sbjct: 362 FYRRQTFLEMTELD-ETITKAAIRIAKQEQLEGHARAMAVRMEDV 405


>UniRef50_Q5WIU9 Histidinol dehydrogenase 1 n=52 Tax=cellular organisms
           RepID=HISX1_BACSK
          Length = 424

 Score =  491 bits (1266), Expect = e-137,   Method: Composition-based stats.
 Identities = 147/412 (35%), Positives = 220/412 (53%), Gaps = 9/412 (2%)

Query: 27  SASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQ 86
            +   + +TV  ++  ++  G+ A+RE S +FD       ++SAEEI      + D++K 
Sbjct: 16  DSHGKVEQTVASLIARIEKEGETAVRELSRQFDNWDPEQFRLSAEEIEKIVRSVPDQVKA 75

Query: 87  AMAVAVKNIETFHTAQK--LPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLM 144
            +  A + I  F   Q+  +  ++VET+PGV       PV SVG YIPGG  P+ ++  M
Sbjct: 76  DICFAQEQIRHFAEQQRASIQDIEVETRPGVFLGHKNIPVNSVGCYIPGGRYPMVASSHM 135

Query: 145 LATPASIAGCKKVVLCSPP---PIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVP 201
               A +AG K+V+ C+PP    I    + A    G  +++ +GG QA+ A+A GTE++ 
Sbjct: 136 SILTAKVAGVKRVIGCTPPINGEIPAATVTAMHFAGADEIYILGGVQAMTAMAVGTETIE 195

Query: 202 KVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAE 261
            VD + GPGNAFV EAKRQ+  R+    ID+ AGP+EVL+IAD  A  + VA+DLL QAE
Sbjct: 196 AVDMLVGPGNAFVAEAKRQLFGRV---GIDLFAGPTEVLIIADDTADGEMVATDLLGQAE 252

Query: 262 HGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALN-ASRLIVTKDLAQCVEIS 320
           HGP S   L+T +  +A      +ERQL  LP A+ A+ A      +I+  DLA+ V  +
Sbjct: 253 HGPTSPAALITTSKKLAEETVAEIERQLQTLPTADVAKVAWEEHGMIILVDDLAEAVVEA 312

Query: 321 NQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSS 380
           ++   EH+ + T N    +D +T+ G++FLG  +  + GD   GTNH LPT         
Sbjct: 313 DKLAYEHVQVLTENPNYFLDHMTNYGALFLGPETNVAYGDKVIGTNHTLPTKKAAKYTGG 372

Query: 381 LGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNALKE 432
           L +  F K  T Q  + E  + +    E L   E    HK   +LRV    +
Sbjct: 373 LWVGKFLKNCTYQRCTPEASAEIGRIAERLCELEGFIGHKAQASLRVKRYGK 424


>UniRef50_Q483H8 Histidinol dehydrogenase 2 n=15 Tax=Proteobacteria
           RepID=HISX2_COLP3
          Length = 446

 Score =  490 bits (1262), Expect = e-137,   Method: Composition-based stats.
 Identities = 150/441 (34%), Positives = 234/441 (53%), Gaps = 16/441 (3%)

Query: 5   TIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDK--TT 62
            I   +  +AEQ+ +LL R   S  ++    V  I++NVK  GD+AL EY+ KFDK   +
Sbjct: 6   KIHRLSDLSAEQRNKLLQR-TESNLDNFIDIVKPIIENVKLNGDKALSEYAKKFDKAEVS 64

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVE-TQPGVRCQQVT 121
              ++V+  E   A   + +E+ Q ++ ++ NI+ FH AQ    + ++  +PG       
Sbjct: 65  TDQIQVTQAEFDEAFTLVDEEVIQTLSYSIDNIKKFHEAQMPEEMWMKQIRPGCYAGDRF 124

Query: 122 RPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCG 177
            P+ +V  YIP G     S  +M A PA +AG    ++ +PP     +    L  A+L G
Sbjct: 125 TPINAVACYIPRGKGSFPSVAIMTAVPAIVAGVPTAIIITPPGTDGKVDAATLVVAKLVG 184

Query: 178 VQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPS 237
           +  VF  GGAQ IAA+A+GT +VPK DK+ GPG+ FV  AK+ ++  +       PAGPS
Sbjct: 185 IDKVFKCGGAQGIAAVAYGTNTVPKCDKVVGPGSPFVVAAKKLLADIIHPGT---PAGPS 241

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPR--A 295
           E +V+AD  A P   A DLL +AEHGPDS   L+T + ++A +   A+      + R   
Sbjct: 242 EAIVLADDTANPKLAALDLLVEAEHGPDSSAFLVTNSKELAEQAQVAINEYWQHMDRLRV 301

Query: 296 ETARQAL--NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDW 353
           + +   L  +   +++T    + V+  N Y  EHL+I +++  + +  I +AG + LG+ 
Sbjct: 302 DFSSTVLSGDNGGIVLTSTFEEAVDFCNDYAAEHLLILSKSPFDHLGKIINAGEILLGEN 361

Query: 354 SPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAA 413
           +P S  +Y  G N VLPT     T S L + D+ K  ++  L++EG+  LA      A  
Sbjct: 362 TPISIANYTLGPNAVLPTSMAAKTASPLSVFDYLKSCSIGYLTREGYEELAPHTYRFAKY 421

Query: 414 ERLTAHKNAVT-LRVNALKEQ 433
           E   AH NAV+ LR  A+K +
Sbjct: 422 EGFDAHANAVSHLRDEAIKSE 442


>UniRef50_A6UA68 Histidinol dehydrogenase n=4 Tax=Proteobacteria RepID=A6UA68_SINMW
          Length = 432

 Score =  487 bits (1255), Expect = e-136,   Method: Composition-based stats.
 Identities = 155/409 (37%), Positives = 223/409 (54%), Gaps = 6/409 (1%)

Query: 23  RPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSD 82
           R A+S +  + +TV +I+ NV+ RGD A+REYSA FDK  +   +VS EE   A   L  
Sbjct: 20  RDAVSDTAPVEKTVKEIIANVRERGDAAVREYSAAFDKVELEKFEVSQEERLKAVAELDP 79

Query: 83  ELKQAMAVAVKNIETFHTAQKLP--PVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFS 140
           + ++    A+ N+  F  AQ     P+++ET PG+       P+  VG Y+PGG  PL S
Sbjct: 80  QTREDTEFAIANVRAFAEAQLKTILPLEIETLPGLHLGHRVIPIEIVGCYVPGGRYPLLS 139

Query: 141 TVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESV 200
             +M   PA +AGC +V+ C PP     ++    L G   +F VGGAQAIAA+A GTE++
Sbjct: 140 APVMTIVPAKVAGCDQVIACLPPNAHPAMIAGCHLSGADRIFRVGGAQAIAAMASGTETI 199

Query: 201 PKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQA 260
           P VDKI GPGNAFV EAKRQV  ++    ID  AGPSE+ ++AD       +A+DLL+QA
Sbjct: 200 PAVDKIVGPGNAFVNEAKRQVFGQV---GIDQLAGPSEIFIVADETGKAAMIATDLLAQA 256

Query: 261 EHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVEI 319
           EH   ++V L+T    +A      VE+QL +L  A  A  A  +   + V +D    +  
Sbjct: 257 EHDVRTRVGLITTDRKLAEETLVEVEKQLQDLSTANVASVAWKDYGEITVCEDETTMIAY 316

Query: 320 SNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCS 379
           S+    EHL + TR+ +     + + GS+F+G+ +     D   GTNH LPT        
Sbjct: 317 SDYIAAEHLQVHTRDPQATARKLRNYGSLFIGELASVVYSDKCCGTNHTLPTMAAGRYTG 376

Query: 380 SLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVN 428
            L +  + K  T Q L + G +A+A      +A ERL  H+ A  LR++
Sbjct: 377 GLWVGSYLKTCTHQWLDERGVAAVAPAAVRQSATERLEGHRRAAALRLS 425


>UniRef50_B1H0F0 Histidinol dehydrogenase n=1 Tax=uncultured Termite group 1
           bacterium phylotype Rs-D17 RepID=B1H0F0_UNCTG
          Length = 419

 Score =  487 bits (1254), Expect = e-136,   Method: Composition-based stats.
 Identities = 144/411 (35%), Positives = 237/411 (57%), Gaps = 22/411 (5%)

Query: 21  LMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA--LKVSAEEIAAASE 78
           +++     ++ I+  V+DI++++K  GDEA+ +Y  KFD   ++    +VS + I  A++
Sbjct: 9   IIKTNQMDAKQISIYVSDIIEDIKNNGDEAVFKYLKKFDNVDLSKKGYRVSQKVIDDAAK 68

Query: 79  RLSDELKQAMAVAVKNIETFHTAQK--LPPVDVETQPGVRCQQVTRPVASVGLYIPGGSA 136
           R+  +LK  +  +  NI  +H  ++  +       + G++  Q  RPV SVGLY+PGG  
Sbjct: 69  RIPKQLKNVIKSSYSNILAYHKYERSQIKKRWNYVKNGLKIGQFYRPVESVGLYVPGGRF 128

Query: 137 PLFSTVLMLATPASIAGCKKVVLCSPPP-IADEILYAAQLCGVQDVFNVGGAQAIAALAF 195
           P  STV+M A PA  AG K++V+ +PP  + D +L++A+LCG+++++ +GG  A+ ALA+
Sbjct: 129 PYPSTVIMTAVPAMAAGVKRIVMVTPPKNMNDAVLFSAKLCGIKEIYCIGGVMAVGALAY 188

Query: 196 GTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASD 255
           GT+++ KVD I GPGNA+V EAK+QV  R+    ID  AGP+EV +IAD     D+V +D
Sbjct: 189 GTKTLKKVDMIVGPGNAYVNEAKKQVFGRV---GIDSLAGPTEVAIIADKDVPTDYVVAD 245

Query: 256 LLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQ 315
           +++Q EH P ++  LL  +A     + + + ++  +  R E                L +
Sbjct: 246 VMAQVEHDPLAKTYLLCESAKKMSEIEKLLPKEALKQLRTELC-------------SLNK 292

Query: 316 CVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYT 375
            V+I N   PEHL +  +N + L+ ++ +AG+VF+G  +P ++GDY +G +HVLPT G  
Sbjct: 293 AVDIVNNIAPEHLELLVKNYQILLKNVRNAGAVFVGYQTPTASGDYWAGPSHVLPTNGSA 352

Query: 376 ATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
              S L +  F KR    E++K    A   TI   A AE +  HK +  +R
Sbjct: 353 KFSSGLSVMTFLKRSAYIEMNKNNKKAYK-TIADFAQAENMQYHKKSAEVR 402


>UniRef50_Q8TXG3 Histidinol dehydrogenase n=1 Tax=Methanopyrus kandleri
           RepID=HISX_METKA
          Length = 431

 Score =  487 bits (1254), Expect = e-136,   Method: Composition-based stats.
 Identities = 169/408 (41%), Positives = 229/408 (56%), Gaps = 11/408 (2%)

Query: 31  SITRTVNDILDNVKARGDEALREYSAKFDKTTVT--ALKVSAEEIAAASERLSDELKQAM 88
            +   V  I ++V  RGDEAL EY+ +FD   +    L+VS ++   A E + +   +A+
Sbjct: 25  EVLPDVERIFEDVVERGDEALLEYTERFDGVKLEAEDLRVSEDDFEVARELVDERTVEAL 84

Query: 89  AVAVKNIETFHTAQKLP-PVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLAT 147
             A   IE FH               G  C    RP+  VG Y+PGG A   ST LM   
Sbjct: 85  EEAAHRIEEFHRKTLPRVDRITFDVEGTECGLTLRPIPRVGCYVPGGRAAYPSTALMTVI 144

Query: 148 PASIAGCKKVVLCSPPPIA-----DEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPK 202
           PA +AGC++VV+C+PP         E+L A ++ G   V+ VGGAQAIAALA GTE+V +
Sbjct: 145 PARVAGCREVVVCTPPADNDVRASPEVLVAVEIAGADAVYRVGGAQAIAALAAGTETVLR 204

Query: 203 VDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEH 262
           VDKI GPGN +VT AK     R     +DMPAGPSEV VIAD  A PD++A DL++QAEH
Sbjct: 205 VDKIVGPGNVYVTAAKLLAYSR-GLTDVDMPAGPSEVFVIADDSANPDWLARDLIAQAEH 263

Query: 263 GPDSQVILLTPAADMARRVAEAVERQL-AELPRAETARQALNASRLIVT-KDLAQCVEIS 320
            P +  +L T + ++AR V E VE  L A + R E   +AL+ +  IV    L +CV ++
Sbjct: 264 DPHAAAVLATDSEEIARAVKERVEELLDAGIEREEIVLKALDRNGWIVVLDSLEECVRLA 323

Query: 321 NQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSS 380
           N+Y PEHL +   N  EL+  + +AG+VF+G  +    GDYA+G NHVLPT G+     +
Sbjct: 324 NRYAPEHLQLCVENPEELLQDVENAGAVFVGHLTAVPFGDYATGPNHVLPTGGFARARGA 383

Query: 381 LGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVN 428
           LG  DF K + +Q L +     LA  +E LA  E L  H  AV  R +
Sbjct: 384 LGTWDFVKIIPIQRLREGDVERLAPIVEELAEREGLPNHAEAVRARRS 431


>UniRef50_Q7UX39 Histidinol dehydrogenase n=6 Tax=Planctomycetaceae RepID=HISX_RHOBA
          Length = 460

 Score =  486 bits (1252), Expect = e-136,   Method: Composition-based stats.
 Identities = 154/402 (38%), Positives = 227/402 (56%), Gaps = 11/402 (2%)

Query: 34  RTVNDILDNVKARGDEALREYSAKFDKTTVTA--LKVSAEEIAAASERLSDELKQAMAVA 91
             V  I  +V+++G EAL  Y+   D   +TA  L+V  E++ AA      +L + +   
Sbjct: 63  EVVETICKDVQSQGTEALLRYTKSLDGAELTADTLRVPEEDLKAAHAVADPKLIETIGRI 122

Query: 92  VKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASI 151
             NI TF +A     V +  +PGV   Q   P+  VG+ +PGG+A   STV+M A PA +
Sbjct: 123 RDNIATFQSAILHRDVTITPRPGVSLTQRYVPIPRVGICVPGGAAAYPSTVMMTAIPAQV 182

Query: 152 AGCKKVVLCSPPP----IADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIF 207
           AG  ++ + +PP        ++L      G+++V+  GGAQA+AA+A+G +++P VDKI 
Sbjct: 183 AGVDEIAVVAPPTPFGAYNTDMLATCHELGIKEVYRCGGAQAVAAMAYGCDALPAVDKIV 242

Query: 208 GPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQ 267
           GPGN FV  AK+ V   +D   ID  AGPSEV+VIAD  A   FVASDLL+QAEH P S 
Sbjct: 243 GPGNLFVALAKKHVFGTVD---IDSFAGPSEVIVIADESANAAFVASDLLAQAEHSPGS- 298

Query: 268 VILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVEISNQYGPE 326
            IL+T    +   V   + RQL EL R + AR AL +   L++ +D     E+++ + PE
Sbjct: 299 AILITWDESLLTSVQAELSRQLGELERGDLARDALSDFGALVLARDADHACELTDSFAPE 358

Query: 327 HLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADF 386
           HL I+TR    L+  I  +G+ FLG  +P + GDYA+G +HVLPT G     + L    F
Sbjct: 359 HLQIETREPESLIAKIRHSGAAFLGHHTPVALGDYAAGPSHVLPTGGTCRWAAGLSANSF 418

Query: 387 QKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVN 428
            +  +V +  +   SA+A  + T+A  E LTAH  ++++R  
Sbjct: 419 LRSGSVTQFDQSALSAIAQDVITVAEKEGLTAHARSISIRTE 460


>UniRef50_P73058 Histidinol dehydrogenase 1 n=11 Tax=Cyanobacteria RepID=HISX1_SYNY3
          Length = 434

 Score =  485 bits (1250), Expect = e-135,   Method: Composition-based stats.
 Identities = 162/438 (36%), Positives = 249/438 (56%), Gaps = 14/438 (3%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFD--K 60
              I+  +  T +Q  QL  R   +  +++     ++++ VK  GD  +  YS +FD   
Sbjct: 1   MTRILKLSHLTPQQLNQLKRRSEQNIDQAL-AIAKEVIEQVKMEGDAGVLHYSRQFDFAG 59

Query: 61  TTVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDV-ETQPGVRCQQ 119
            T   L+VS  E A A + +  EL++A+  A +NIE  H  Q  PP+ + E +PGV   +
Sbjct: 60  ATAENLRVSEAEFAEAEKLVDPELRRAVEHAFRNIEKVHAGQMPPPMHLAEIEPGVFAGE 119

Query: 120 VTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQL 175
              P+ +VGLY+P G     S +LMLA PA +AG KK+V+C+PP     +    L  A++
Sbjct: 120 KITPLPTVGLYVPRGKGAFPSMMLMLAVPARVAGVKKIVVCTPPDKEGKVEPVSLVTARM 179

Query: 176 CGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAG 235
            GV +V+ +GG QA+AA+A+GT++V KVDK+ GP + +   AKR +S  +D   + +PAG
Sbjct: 180 AGVDEVYKLGGVQALAAIAYGTKTVSKVDKLIGPCSIYGAAAKRLLSGIVD---VGLPAG 236

Query: 236 PSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELP-- 293
           PSE +V+AD    P   A DLL +AEHG DS  +L+T +A +A +    +   L +LP  
Sbjct: 237 PSESIVLADETTDPKLAALDLLIEAEHGSDSAALLVTHSASLAEKALGYLGEYLEKLPPW 296

Query: 294 RAETARQAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGD 352
           R +     L +   +++T  L   ++  N Y PEHL + T +  +LV  I +AG + LG+
Sbjct: 297 RKKFCEDGLGSYGGILLTDSLQASLDFINDYAPEHLQVLTADPLKLVGKIDNAGEILLGN 356

Query: 353 WSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAA 412
           ++P SA  YA G N VLPT G+  + S++ + DF KR T+  L++EGF+ +  T+ TLA 
Sbjct: 357 YTPSSAATYAIGVNAVLPTGGFARSYSAVSVFDFLKRSTLAYLTEEGFAGVKETVTTLAD 416

Query: 413 AERLTAHKNAVTLRVNAL 430
            E   AH  A+  R N L
Sbjct: 417 YEDFPAHALAIRERENLL 434


>UniRef50_A1ZJE8 Histidinol dehydrogenase n=1 Tax=Microscilla marina ATCC 23134
           RepID=A1ZJE8_9SPHI
          Length = 429

 Score =  485 bits (1250), Expect = e-135,   Method: Composition-based stats.
 Identities = 169/424 (39%), Positives = 260/424 (61%), Gaps = 9/424 (2%)

Query: 14  AEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEI 73
            E   +L  R      E++ + V  IL  V+  GD+ALR +  K+D+  +   +++ EE+
Sbjct: 9   KEDWSKLQER-TFETYEALEKAVRPILRRVQREGDKALRSFVFKYDRVRIKRFQLTPEEL 67

Query: 74  AAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPG 133
           A AS  +SDELK+A+ VA  NI TFH  Q      +ET  GV   Q   P+A VGLY+P 
Sbjct: 68  AEASNHVSDELKEAINVAKYNIATFHLTQTKAVKKIETTEGVFSWQKNVPIAKVGLYVPS 127

Query: 134 -GSAPLFSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQDVFNVGGAQ 188
            G APL+S +LM+   A+IAGCK+++LCS       I   ILY A L  ++ V+ VGG Q
Sbjct: 128 TGDAPLYSHILMMGILANIAGCKEIILCSAANHEGRIHPIILYTAHLLNIKKVYRVGGVQ 187

Query: 189 AIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGAT 248
           AIAA+A+GTE++PKVDKIFGP N +V+ AK+ VS+  +  AIDMP GPSE+  +AD    
Sbjct: 188 AIAAMAYGTETIPKVDKIFGPSNEYVSTAKQLVSK--NDVAIDMPVGPSELCYVADQSTN 245

Query: 249 PDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELP-RAETARQALNASRL 307
           P + A+D+L+ AE    +Q+++LT A ++A ++   V++QL ELP + E A++    +++
Sbjct: 246 PVYAAADILAHAEQSSHNQLVVLTNAEEVADKIQAEVDKQLNELPLKKEVAKEVFKNAKI 305

Query: 308 IVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNH 367
           IV K   + +  +N+Y PE+L++   NA  + D IT+A S+ LG  +P + G YA+G NH
Sbjct: 306 IVFKSNVESIAFANEYAPENLVLAIDNAEAVGDRITNASSIHLGHLTPPAVGYYAAGPNH 365

Query: 368 VLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRV 427
           +LP+ G+  + S L +  F K++  Q+++  G   + ST+ T++ AE L   KN++  R+
Sbjct: 366 ILPSNGFARSYSGLSVDSFVKKINFQQVTPLGLQNVGSTVATMSEAEELLGRKNSIIKRL 425

Query: 428 NALK 431
             L 
Sbjct: 426 ELLD 429


>UniRef50_Q4FNE2 Histidinol dehydrogenase 1 n=3 Tax=Candidatus Pelagibacter
           RepID=HISX1_PELUB
          Length = 428

 Score =  484 bits (1247), Expect = e-135,   Method: Composition-based stats.
 Identities = 144/431 (33%), Positives = 244/431 (56%), Gaps = 8/431 (1%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              I+D  +   ++    L+    +  +  + +V  I+ +VK  GD+A+ +Y  +F+K +
Sbjct: 1   MIKILDSKNKNFDKTLDALLSKRKNKVQLNSVSVIKIIKDVKKNGDKAILKYEKRFNKNS 60

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
           +  +  S ++I  A + L  ++K+A+ +A   I  FH+ QK   +    +   + +    
Sbjct: 61  I--IAPSIKQINRAIQSLDQKVKKAIDLAYDRIYKFHSLQKFKNISYTDKLKNKLEYKYV 118

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPI---ADEILYAAQLCGVQ 179
           P+ SV +Y+PG +A   S+VLM A PA +AG K++V+ +P         +LYAA+ C ++
Sbjct: 119 PIESVAIYVPGSTASYPSSVLMNAVPAIVAGVKRLVMVNPGQKGKQNPAVLYAAKKCKIK 178

Query: 180 DVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEV 239
           +++++GG  AIAA+A+GT+ + KVDKI GPGN++V  AK++V   +      M AGPSEV
Sbjct: 179 EIYSIGGPSAIAAVAYGTKKIKKVDKIIGPGNSYVAAAKKEVFGDVGIEG--MIAGPSEV 236

Query: 240 LVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETAR 299
            ++ D  + P+++ASDL+ QAEH   +Q IL++    + ++V   +  QL ELPRA  A+
Sbjct: 237 TIVCDKFSNPEWIASDLIGQAEHDNLAQCILISKDKSIIKKVNYEIINQLKELPRAVIAK 296

Query: 300 QAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESA 358
            +L N   LI      + +   N+  PEHL + T+N +++V  I +AGS+ LG ++  + 
Sbjct: 297 NSLLNNGILIYMPSDQKIINTVNKIAPEHLELNTKNYKKVVSKIKNAGSICLGKYAVMAM 356

Query: 359 GDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTA 418
            DY  G+NHVLPT       S + + +F KR++   LSK+G   L  ++ TLA  E L  
Sbjct: 357 TDYNVGSNHVLPTNSSARYSSGVSVNEFYKRISYINLSKKGIETLGPSVITLANYEGLVG 416

Query: 419 HKNAVTLRVNA 429
           H  +V  R+  
Sbjct: 417 HAKSVEKRIRR 427


>UniRef50_B3T638 Histidinol dehydrogenase n=1 Tax=uncultured marine crenarchaeote
           HF4000_ANIW141N1 RepID=B3T638_9ARCH
          Length = 434

 Score =  483 bits (1243), Expect = e-135,   Method: Composition-based stats.
 Identities = 157/422 (37%), Positives = 240/422 (56%), Gaps = 21/422 (4%)

Query: 24  PAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDE 83
                SE   +TV  IL++V+  GD A+++Y  KF+    + L+VS +EI  A E     
Sbjct: 17  RRQKTSEKDRKTVQAILNDVRKNGDSAVKKYERKFNGRKTSQLRVSNKEIGEAEELPDPT 76

Query: 84  LKQAMAVAVKNIETFH----TAQKL--------PPVDVETQPGVRCQQVTRPVASVGLYI 131
                 + ++  + +       QKL         P      P ++ ++   P+ SVG YI
Sbjct: 77  DNIWTKLYLQEWDLYWNLSGRKQKLRKGGFCYEKPYFWGGLP-LKTEKRFVPIPSVGCYI 135

Query: 132 PGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQDVFNVGGA 187
           PGG A   S+V+M   PA IAG K++V+ SPP     I    + AA +CGV +++ VGGA
Sbjct: 136 PGGQARYPSSVVMSVLPAKIAGVKRIVIVSPPGRDGKIDPLTISAAAMCGVTEIYKVGGA 195

Query: 188 QAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGA 247
           QAI ALA+GT+S+PKVDKI GPG  FV+ AK  VS++    +IDM AGP+E+ ++AD+ +
Sbjct: 196 QAIGALAYGTKSIPKVDKIVGPGGKFVSIAKAIVSEQ---TSIDMIAGPTELGIMADTSS 252

Query: 248 TPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASR 306
            P+ VA DL+SQAEH  D+   ++T +  +A+++ +++E+ +    R+   R++L     
Sbjct: 253 DPELVALDLISQAEHSKDTMCFVITQSKIIAKQIQKSIEKLIPGTERSSIIRESLTKNGF 312

Query: 307 LIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTN 366
           + V K+  + +E++N+  PEHL +  +NAR L   IT AG + +G  +P SA DY  GTN
Sbjct: 313 IAVCKNENEMIELANKIAPEHLELMVKNARSLSKKITGAGLLLIGKNTPSSASDYILGTN 372

Query: 367 HVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
           H+LPT G+  T   L + DF K  T+ E  K    AL+S ++ L  AE L  H  AV  R
Sbjct: 373 HILPTNGFGRTRGGLSVLDFLKLQTIVESKKSTLKALSSDLKALTDAEGLPNHYKAVKRR 432

Query: 427 VN 428
           ++
Sbjct: 433 LD 434


>UniRef50_Q13I58 Histidinol dehydrogenase n=22 Tax=cellular organisms
           RepID=Q13I58_BURXL
          Length = 443

 Score =  482 bits (1241), Expect = e-134,   Method: Composition-based stats.
 Identities = 141/424 (33%), Positives = 211/424 (49%), Gaps = 10/424 (2%)

Query: 17  QRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAA 76
           +R         +   +   V  I+ +++ +GDEA+REYS KFD       ++S  EI  A
Sbjct: 10  KRGRTAAGKSDSDAKVRAIVESIIQHIEEKGDEAVREYSRKFDNWDPGDFRLSRPEIETA 69

Query: 77  SERLSDELKQAMAVAVKNIETFHTAQK--LPPVDVETQPGVRCQQVTRPVASVGLYIPGG 134
            ++LS    + +A A   +  F   Q+  +  V+ ET PGV       P+ +VG YIPGG
Sbjct: 70  RKQLSAREIEDIAFAQTQVRNFARIQRDSMRDVETETLPGVVLGHKHIPMNAVGCYIPGG 129

Query: 135 SAPLFSTVLMLATPASIAGCKKVVLCSPP---PIADEILYAAQLCGVQDVFNVGGAQAIA 191
             PL ++  M    A +AG  +VV  +PP        I+ A  + G  ++  +GG QA+ 
Sbjct: 130 KYPLLASAHMSVLTAKVAGVARVVSTAPPYQGKPHPAIVTAMDMAGADEILVLGGIQAVV 189

Query: 192 ALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDF 251
           A+A GT +V  VD + GPGN FV EAKRQ+  R+    ID+ AGP+E LVIAD     + 
Sbjct: 190 AMAVGTPTVAPVDMLVGPGNMFVAEAKRQLYGRV---GIDLFAGPTETLVIADESVDGEL 246

Query: 252 VASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVT 310
            A DLL QAEHG  S  ILLT +  +AR     +ERQL  LP A  A Q+  +   +IV 
Sbjct: 247 CAVDLLGQAEHGATSPSILLTNSEKLARDTLAEIERQLKILPTASIAAQSWADCGEVIVC 306

Query: 311 KDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLP 370
               + +++++    EH+ + T +    ++++T+ G++FLG  +  S GD   GTNH LP
Sbjct: 307 DTYEEMLQVADDIASEHVQVMTEDPDFFLNNMTNYGALFLGPRTNVSFGDKVIGTNHTLP 366

Query: 371 TYGYTATCSSLGLADFQKRMTVQEL-SKEGFSALASTIETLAAAERLTAHKNAVTLRVNA 429
           T         L +  F K  T Q + + E  + +      L   E    H     +RV  
Sbjct: 367 TNRSARYTGGLWVGKFLKTCTYQRVTTNEASAIIGEYCSRLCHMENFAGHGEQANIRVRR 426

Query: 430 LKEQ 433
              +
Sbjct: 427 YGNR 430


>UniRef50_UPI00017455E1 Histidinol dehydrogenase n=1 Tax=Verrucomicrobium spinosum DSM 4136
           RepID=UPI00017455E1
          Length = 428

 Score =  481 bits (1240), Expect = e-134,   Method: Composition-based stats.
 Identities = 161/428 (37%), Positives = 242/428 (56%), Gaps = 11/428 (2%)

Query: 6   IIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA 65
           I+ +           L R A  AS+ +   V  ++ +++  GD+AL E + KFD  T+TA
Sbjct: 3   ILRYTDAAYADALCRLNRRA-EASDRVRDVVAAVIADIRQNGDKALLELTQKFDGATLTA 61

Query: 66  --LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRP 123
             L VS EE+AAA   L+ E++ A+  +++N+ TF          +  + G    +V  P
Sbjct: 62  EQLVVSTEEVAAAVASLTPEVRAALDASLRNVTTFAHQSLRKDWSMINEQGAEVGEVYHP 121

Query: 124 VASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLC----GVQ 179
              VG+Y+PGG+APL ST +M    A+ AG  ++V+CSP     ++           G  
Sbjct: 122 FERVGVYVPGGTAPLVSTAIMTVAIAAAAGVPEIVVCSPCGKDGKVNANLLAALSLAGAT 181

Query: 180 DVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEV 239
           +++ VGG+QAIAA+AFGTE++  V KIFGPGN++V EAKRQV   +   ++D+  GPSEV
Sbjct: 182 EIYRVGGSQAIAAMAFGTETIKPVTKIFGPGNSYVVEAKRQVFGVV---SVDLLPGPSEV 238

Query: 240 LVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETAR 299
           +V+ADS A P F+A+DLL+QAEHG DS V  LT    +   V   VE Q  +L R E  R
Sbjct: 239 MVLADSSANPAFIAADLLAQAEHGKDSGVAFLTDDETLLNAVVSQVETQGQKLTRQEMVR 298

Query: 300 QALNAS-RLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESA 358
             L+    L++   L +  EI N Y PEHL + T    +++  I +AG++FLG++SP + 
Sbjct: 299 SVLDKECFLMLVPTLEEGAEIVNNYAPEHLSLITAREHDILPLIRTAGAIFLGNYSPVAV 358

Query: 359 GDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTA 418
           GD+ +G +H LPT G   +   L +  FQKR ++  LSKE  +     +   +  E L A
Sbjct: 359 GDFLAGPSHTLPTGGAGKSFPGLTVDMFQKRTSIVRLSKEACAKSEPIVRVFSEIEGLDA 418

Query: 419 HKNAVTLR 426
           H  +V++R
Sbjct: 419 HGLSVSVR 426


>UniRef50_D0XPF3 Histidinol dehydrogenase n=1 Tax=Brevundimonas subvibrioides ATCC
           15264 RepID=D0XPF3_9CAUL
          Length = 440

 Score =  481 bits (1239), Expect = e-134,   Method: Composition-based stats.
 Identities = 176/429 (41%), Positives = 251/429 (58%), Gaps = 9/429 (2%)

Query: 7   IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTAL 66
           IDW S   + +   L RP+  +   +   V+ I + V   G  A+ +++ + D      +
Sbjct: 9   IDWASLDGQGRFDALARPSRRSERDVQDVVSGIFEQVALSGGLAVTQFAERIDGFKPRRI 68

Query: 67  KVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPV-DVETQPGVRCQQVTRPVA 125
            ++ E +AAA + L     +A+ VA +N+  FH A K      VET PGV+ + V RP+ 
Sbjct: 69  AITPEAVAAARDALPPADTRALRVAAENVRVFHQATKPEDTAFVETTPGVKSKLVWRPIG 128

Query: 126 SVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQDV 181
           + G+Y+PGG+APLFS++LM A PA +AG    V+ +PP     +   ++ AA    +  +
Sbjct: 129 AAGIYVPGGTAPLFSSLLMQAIPAEVAGVTTRVVVTPPAKDGSVHPAMILAAAEANLDAI 188

Query: 182 FNVGGAQAIAALAFGT----ESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPS 237
           + +GGAQAIAAL +G       +P  DK+FGPGNA+V EAKR  +   +G ++DMPAGPS
Sbjct: 189 WLIGGAQAIAALTYGAVLDDGEIPACDKLFGPGNAYVAEAKRYAAALPNGPSVDMPAGPS 248

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAET 297
           E+LVIAD    P+  A+DLLSQAEH  D+QVIL+   A     +   VE QL  LPRA+ 
Sbjct: 249 ELLVIADRFCDPEIAAADLLSQAEHDADAQVILVCERAATIDAILAEVEEQLTTLPRADI 308

Query: 298 ARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPES 357
           AR +L+ +R I+  D+A+   +SN YGPEHL IQ  +A  LV SI +AG+VF+G W+ E+
Sbjct: 309 ARASLSEARAILVSDMAEACAVSNLYGPEHLAIQAEDAEALVASIRAAGAVFVGRWAAET 368

Query: 358 AGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLT 417
            GDYA+G +HVLPT G   T   +  A F   M+VQ +++ G   L      LA  E L 
Sbjct: 369 LGDYAAGPSHVLPTDGGARTLGGITTASFMTSMSVQTVTEAGAERLGPIAARLARLEGLE 428

Query: 418 AHKNAVTLR 426
           AH  A  LR
Sbjct: 429 AHARAADLR 437


>UniRef50_Q67KH6 Histidinol dehydrogenase n=1 Tax=Symbiobacterium thermophilum
           RepID=HISX_SYMTH
          Length = 439

 Score =  481 bits (1238), Expect = e-134,   Method: Composition-based stats.
 Identities = 163/429 (37%), Positives = 234/429 (54%), Gaps = 12/429 (2%)

Query: 14  AEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA--LKVSAE 71
            +   + L R        I   V  IL+ V+  GD AL  ++ +FD   + A  L+V+  
Sbjct: 7   PQAFLEFLNRRRTEFYPEIEAQVRAILERVRREGDGALYAFTRQFDGADLEATGLRVTEA 66

Query: 72  EIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYI 131
           E   A   +S   + A+ VAV+NI  FH  Q           G    Q   PV   G+Y+
Sbjct: 67  EYREAEAAVSAAFRAALQVAVENIAAFHRPQVPTSWFTTRPDGTIVGQRVTPVDRAGVYV 126

Query: 132 PGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQDVFNVGGA 187
           PGGSAPLFS +LM A PA +AG  +V++C+PP     I   +L AA+  GV+DV+ VGGA
Sbjct: 127 PGGSAPLFSCLLMTAIPAVVAGVPEVIVCTPPDRNGRIDPHMLVAARAAGVKDVYKVGGA 186

Query: 188 QAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGA 247
           QAI A+A+GT +VP+VDKI GPGN +VT AK+ V   +    IDM AGP+EV+ + D   
Sbjct: 187 QAIGAMAYGTATVPRVDKIAGPGNYYVTLAKKLVFGPV---GIDMLAGPTEVMAVDDGSV 243

Query: 248 TPDFVASDLLSQAEHGPDSQVILLTPA-ADMARRVAEAVERQLAELPRAETARQALNA-S 305
             +++A+DLLSQAEH P+  VIL+T A  +    V  A+ R  A LPRAET R+++    
Sbjct: 244 DAEWLAADLLSQAEH-PNGMVILVTTAGPERIAAVGAAMARHTAALPRAETIRRSVAELG 302

Query: 306 RLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGT 365
             +    L +  ++ N  GPEHL +   +    +  +  AGS+FLG W+PE+ GDY +G 
Sbjct: 303 AALAVDTLEEAADLVNAVGPEHLEVGVADPWAFLPLVRHAGSIFLGRWTPEAMGDYIAGP 362

Query: 366 NHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTL 425
           ++V+PT G     S + +  F KR  V   S+  F A A     LA  E L AH  ++ +
Sbjct: 363 SNVIPTEGTARYASPVCVETFIKRSAVTCYSEAAFRAQAPHAVRLALTEDLLAHAASMQI 422

Query: 426 RVNALKEQA 434
           R+     ++
Sbjct: 423 RLAKPDGES 431


>UniRef50_B4W8G9 Histidinol dehydrogenase n=2 Tax=Caulobacteraceae
           RepID=B4W8G9_9CAUL
          Length = 435

 Score =  480 bits (1237), Expect = e-134,   Method: Composition-based stats.
 Identities = 193/433 (44%), Positives = 261/433 (60%), Gaps = 9/433 (2%)

Query: 5   TIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVT 64
            +IDW+S  A  +R  L RPA   +  +T  V  ILD+V+ARG  A+ ++  K DK    
Sbjct: 2   KLIDWSSLDAAGKRAALARPAQRTAGDVTDVVRTILDDVRARGGAAVTDWCLKLDKAPPR 61

Query: 65  ALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPV-DVETQPGVRCQQVTRP 123
            + ++ E +A A   L     +A+ +A +N+  FH A K      +ET PGVR +   RP
Sbjct: 62  RIAITPEAVAEARNALPPGDVRALRMAAENVRVFHQATKPEDTPFIETTPGVRSKLAWRP 121

Query: 124 VASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQ 179
           +AS GLYIPGG+APLFS++LMLA PA +AG  + V  +PP     I   ++ AA    + 
Sbjct: 122 IASAGLYIPGGTAPLFSSLLMLAIPAGVAGVGERVAVTPPDKNGGIHPAMILAAAEAELD 181

Query: 180 DVFNVGGAQAIAALAFGTE----SVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAG 235
            ++ +GGAQAIAAL FG E     +P  DK+FGPGNA+V EAK+Q S    G A+DMPAG
Sbjct: 182 AIWLMGGAQAIAALTFGVELEDGIIPACDKLFGPGNAYVAEAKKQASALPGGPAVDMPAG 241

Query: 236 PSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRA 295
           PSE++VI D  A P+  A+DLLSQAEH  D+QVIL++ +      +   VE Q+A LPR 
Sbjct: 242 PSELMVIVDRDAAPEIAAADLLSQAEHDADAQVILVSTSRATIDYILSEVEVQVAALPRE 301

Query: 296 ETARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSP 355
             AR +LN +R I+ +DL    E++N YGPEHL IQ  +   LVDSI +AG+VF+G ++ 
Sbjct: 302 AIARASLNEARAILVRDLDAAAEVANLYGPEHLAIQIDDPEPLVDSIKAAGAVFVGRFAA 361

Query: 356 ESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAER 415
           E+ GDYA+G +HVLPT G   T   +  A F   M+VQ +S+ G  ALA     LA  E 
Sbjct: 362 ETLGDYAAGPSHVLPTDGGARTLGGVTTASFMTTMSVQLVSEAGARALAPIAARLARMEG 421

Query: 416 LTAHKNAVTLRVN 428
           L AH  A  LR  
Sbjct: 422 LEAHARAADLRAE 434


>UniRef50_D1N997 Histidinol dehydrogenase n=2 Tax=Lentisphaerae RepID=D1N997_9BACT
          Length = 431

 Score =  479 bits (1235), Expect = e-134,   Method: Composition-based stats.
 Identities = 170/436 (38%), Positives = 239/436 (54%), Gaps = 13/436 (2%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              +   ++      ++L  RP  S    I      I+ +VKA GD AL  Y+AKFD   
Sbjct: 1   MKKLYFGSADFEADLKKLYDRP--SYPPEIEAQAAAIIADVKAEGDAALVRYAAKFDHAE 58

Query: 63  VTA--LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQV 120
           +T    +V+ +EIAAA ++L   LK A+  A++ +  F             +PGV   + 
Sbjct: 59  LTPAQFRVTGDEIAAAEKQLPARLKSAIRTALRQVRDFAKLTIPKGWTASPRPGVTLGEK 118

Query: 121 TRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLC 176
             P+  VG+YIPGG+APL STVL  A  A  A  K++V  +PP     +   +LYA +L 
Sbjct: 119 FEPLDRVGVYIPGGTAPLVSTVLHTAGIAGAAKVKEIVAVTPPGRDGKVHPAVLYAMKLA 178

Query: 177 GVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGP 236
           GV +++ +GG   +AALA GTE++ KV+KI GPGNA+VT AK+ +  ++   AIDM AGP
Sbjct: 179 GVTEIYRLGGVYGVAALACGTETIAKVEKIVGPGNAYVTAAKKLLYGQV---AIDMVAGP 235

Query: 237 SEVLVIADSGATPDFVASDLLSQAEHGP-DSQVILLTPAADMARRVAEAVERQLAELPRA 295
           SE+LVIAD  A P F+A+DLLSQAEHG    Q +L+T    M  RV     RQ A LPR 
Sbjct: 236 SEILVIADETADPSFIAADLLSQAEHGSGLEQAVLVTTDKAMIDRVEAEFLRQKATLPRL 295

Query: 296 ETARQALNAS-RLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWS 354
            T  +       LI T DL     I++ Y PEHL IQT    ++   IT+AG++FLG W+
Sbjct: 296 ATVDRVQEHGLFLIHTPDLDTAAAIASSYAPEHLEIQTARPEQVARKITAAGAMFLGKWT 355

Query: 355 PESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAE 414
           PE  GD+ +G +HVLPT       + L    F +R ++ + ++       S +E  A  E
Sbjct: 356 PEPVGDFCAGPSHVLPTASSARYFNGLETVSFFRRSSIVKYTEAAIRREVSMVEAFAEME 415

Query: 415 RLTAHKNAVTLRVNAL 430
            L AH  + T+RV  L
Sbjct: 416 GLAAHGRSGTIRVKPL 431


>UniRef50_Q64EP7 Histidinol dehydrogenase n=2 Tax=environmental samples
           RepID=Q64EP7_9ARCH
          Length = 419

 Score =  478 bits (1232), Expect = e-133,   Method: Composition-based stats.
 Identities = 172/410 (41%), Positives = 241/410 (58%), Gaps = 26/410 (6%)

Query: 31  SITRTVNDILDNVKARGDEALREYSAKFDKTTV---TALKVSAEEIAAASERLSDELKQA 87
           ++   VN+I+  VK+RGD AL +Y+ KFD         L+V   EI  A   + D L ++
Sbjct: 23  AVMPLVNEIIAEVKSRGDRALLDYTEKFDGVKFLRQKDLEVRRSEIEDAKRNVDDHLLRS 82

Query: 88  MAVAVKNIETFHTAQKL-----PPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTV 142
           +  A + I+ FH  QK         D     G+       P+  VG Y+P   A  FST 
Sbjct: 83  IEKASEAIKKFHYRQKRRVEVEKGEDKGGTEGMFIDNTYVPLDVVGAYVP---ASYFSTA 139

Query: 143 LMLATPASIAGCKKVVLCSPPPIADEI-----LYAAQLCGVQDVFNVGGAQAIAALAFGT 197
           LM   PA IAG + +++C+PP     +     L AA+L G   +F VGGAQAIAALAFGT
Sbjct: 140 LMCVIPAKIAGVRNILVCTPPGKDGAVDSLTLLAAAELAGATRIFKVGGAQAIAALAFGT 199

Query: 198 ESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLL 257
           E++PKV KI GPGN +VT AK   + R  G  ID PAGPSE+++IAD  A P F+ +D+L
Sbjct: 200 ETIPKVQKIVGPGNVYVTAAKM--AARAQGVEIDFPAGPSEIIIIADETANPLFIVADML 257

Query: 258 SQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQCV 317
           +QAEHG  S+ +LLT +A    R+A  VERQ+    R E   +    + +I+  D+ +C+
Sbjct: 258 AQAEHGAKSKAVLLTDSA----RIAAEVERQI----RTEAGDEEGEQNGIILGDDIGECI 309

Query: 318 EISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTAT 377
           E++N+Y PEHL I  R  +E++  I +AGSVF+GD+SP +AGDYA+G NHVLPT GY  +
Sbjct: 310 ELANEYAPEHLEIMVREPKEVLKRIKNAGSVFVGDYSPVAAGDYATGANHVLPTAGYAKS 369

Query: 378 CSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRV 427
            S L +  F +RMTVQ L KEG + +   +  ++ AE +  H  +V  R 
Sbjct: 370 FSGLDVHHFMRRMTVQWLDKEGLAKIKDVVVKMSRAEGMEKHAQSVEARF 419


>UniRef50_Q4JW59 Histidinol dehydrogenase n=104 Tax=Actinobacteria (class)
           RepID=HISX_CORJK
          Length = 450

 Score =  473 bits (1219), Expect = e-132,   Method: Composition-based stats.
 Identities = 158/436 (36%), Positives = 233/436 (53%), Gaps = 15/436 (3%)

Query: 10  NSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVS 69
            + T  + R  L R      +S+  TV  I+D V+  G  A  E   +FD  T  +++V 
Sbjct: 16  QAPTTAELRHRLPRGGTDV-DSVIPTVAPIVDQVREGGARAALEIGQRFDGVTPDSVRVP 74

Query: 70  AEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGL 129
           AE I AA   L+D++  A+  A+K +  FH+A +     VE  PG    +   PV  VGL
Sbjct: 75  AEVIDAAVGTLADDVIAALEEAIKRVRAFHSAIRPEDKQVEVAPGGIVTERFIPVQRVGL 134

Query: 130 YIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPI----ADEILYAAQLCGVQDVFNVG 185
           Y PGG+A   S+V+M   PA  AG + +V+ SPP         +L A +L GV +V+ VG
Sbjct: 135 YAPGGNAVYPSSVIMNVVPAQEAGVESLVVASPPQEGGWPHPTVLAACKLLGVDEVWAVG 194

Query: 186 GAQAIAALAFGT-----ESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVL 240
           GAQA+A LA G+     E +  VD + GPGN FVT AKR     +    ID  AGP+E+ 
Sbjct: 195 GAQAVALLAHGSTAEGGEELEPVDMVTGPGNIFVTAAKRLCRSVV---GIDSEAGPTEIA 251

Query: 241 VIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQ 300
           V+AD  A    +A DL+SQAEH   +  +L+T +  +A  V   +  +      +E   +
Sbjct: 252 VLADESANAVEIAYDLISQAEHDTMAASVLITDSEKLADEVVAEMNERYHITENSERVAE 311

Query: 301 ALN--ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESA 358
           AL+   S +++  D+A  +  +N YG EHL I T +A  +   IT+AG++F+G +SP   
Sbjct: 312 ALSGQQSGVVLVDDIAAGIRAANAYGAEHLEIHTEDAHGVAAQITNAGAIFIGRFSPVPL 371

Query: 359 GDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTA 418
           GDYA+G+NHVLPT G     S L    F K + V + ++EG   +A T+ TL+ +E L A
Sbjct: 372 GDYAAGSNHVLPTSGTARHSSGLSTLTFLKSVHVIDYNEEGLRGVADTVITLSKSEGLPA 431

Query: 419 HKNAVTLRVNALKEQA 434
           H  A++ R +      
Sbjct: 432 HGEAISARTSTANTNG 447


>UniRef50_A9A5X6 Histidinol dehydrogenase n=2 Tax=Thaumarchaeota RepID=A9A5X6_NITMS
          Length = 420

 Score =  472 bits (1216), Expect = e-131,   Method: Composition-based stats.
 Identities = 149/416 (35%), Positives = 233/416 (56%), Gaps = 10/416 (2%)

Query: 18  RQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAAS 77
            Q L +     S    + V  IL +VK  GD A+++Y  KF    V++L+VS  +IA+A 
Sbjct: 10  EQFLKKIGTKDSSKNQKIVKSILKDVKKNGDVAVKKYEKKFS-AKVSSLRVSQRDIASAY 68

Query: 78  ERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQ-PGVRCQQVTRPVASVGLYIPGGSA 136
            ++S E   A+ +A   +    +A +    D+  +  G +  +   P+ SVG Y+PGG+A
Sbjct: 69  FKVSKEDISAIKLAKSRLSKAESAVRRQFKDITIKSNGTKLSKSFVPIDSVGCYVPGGAA 128

Query: 137 PLFSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQDVFNVGGAQAIAA 192
              S+ +M   PA IAG K++V+ SPP     I    + AA LCG  +++  GG Q+IAA
Sbjct: 129 RYPSSAIMSVVPAKIAGVKRIVVVSPPNSSGNIDPLTIVAADLCGATEIYKTGGVQSIAA 188

Query: 193 LAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFV 252
           L +GT S+ KV+KI GPG AFVT AK  VS  +   +IDM AGP+E+ ++ DS A  D  
Sbjct: 189 LTYGTRSIKKVNKIVGPGGAFVTLAKYLVSNIV---SIDMMAGPTELGIVIDSAADVDVA 245

Query: 253 ASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKD 312
           A DL+SQAEH  D+    LT +  +A+++  +V  +L ++ R +  + +L ++  I    
Sbjct: 246 ALDLISQAEHSSDTFCYALTTSNSIAKKIQSSVNSKLKDIQRVKIVKSSLESNGFIGVCK 305

Query: 313 LAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTY 372
            +  ++I+N   PEHL I ++N ++  + I + G +  G  SP SA DY  G+NH+LPT 
Sbjct: 306 PSDIIDIANDLAPEHLEIISKNPKKW-NKIKNPGLILYGKNSPSSASDYLLGSNHILPTN 364

Query: 373 GYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVN 428
           G+  T  SL + DF K +T  E +K+    ++ +++ L  AE L  H  AV  R+ 
Sbjct: 365 GFGKTRGSLSVLDFVKLLTKIETTKKDLQKISKSMKNLTLAEGLPNHYEAVRGRLK 420


>UniRef50_A3Q131 Histidinol dehydrogenase n=6 Tax=Mycobacterium RepID=A3Q131_MYCSJ
          Length = 474

 Score =  471 bits (1213), Expect = e-131,   Method: Composition-based stats.
 Identities = 156/463 (33%), Positives = 226/463 (48%), Gaps = 47/463 (10%)

Query: 10  NSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVS 69
            + +  Q R  L R  +   +++   V  I++ V  RG EA  EY   FD     +++V 
Sbjct: 16  RTLSTAQLRSALPRGGVDV-DAVVPKVRPIVEAVAERGAEAALEYGEAFDGVRPASVRVP 74

Query: 70  AEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGL 129
           AE +A+A   L  +++ A+ VA+      H  Q+         PG    +   P+  VGL
Sbjct: 75  AERLASALAELDPDVRAALQVAIDRARAVHADQRRTDTTTTLAPGATVTERWVPLERVGL 134

Query: 130 YIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPI------ADEILYAAQLCGVQDVFN 183
           Y+PGG+A   S+V+M   PA  AG   +V+ SPP           IL AA L GV +V+ 
Sbjct: 135 YVPGGNAVYPSSVVMNVVPAQTAGVDSLVIASPPQADHGGLPHPTILAAAALLGVDEVWA 194

Query: 184 VGGAQAIAALAFGTESV-----------------------------------PKVDKIFG 208
           VGGAQA+A LA+G   +                                     VD I G
Sbjct: 195 VGGAQAVALLAYGGTDIDGTGASGAPGDGTGASGAPGDGTGASGAPGDVTELAPVDMITG 254

Query: 209 PGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQV 268
           PGN +VT AKR    ++    ID  AGP+E+ V+AD  A P  VA+DL+SQAEH   +  
Sbjct: 255 PGNIYVTAAKRICRSQV---GIDAEAGPTEIAVLADHTADPVHVAADLISQAEHDEMAAS 311

Query: 269 ILLTPAADMARRVAEAVERQLAELPRAETARQAL--NASRLIVTKDLAQCVEISNQYGPE 326
           +L+T + D+A  +   + RQL      E    AL    S +++  DL   V + N Y  E
Sbjct: 312 VLVTTSPDLADAIDRELRRQLETTVHRERVSTALTGEQSAIVLVDDLDAGVRVVNAYAAE 371

Query: 327 HLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADF 386
           HL IQT +A E+   I SAG++F+G ++P S GDY +G+NHVLPT G     S L +  F
Sbjct: 372 HLEIQTVDAAEVAGRIRSAGAIFVGPYAPVSLGDYCAGSNHVLPTAGCARHSSGLSVQTF 431

Query: 387 QKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNA 429
            + + V + ++     ++  + TLA AE L AH  AV  R  +
Sbjct: 432 LRGIHVVDYTEAALKDVSGYVITLAQAENLPAHGEAVRRRFES 474


>UniRef50_Q1AX10 Histidinol dehydrogenase n=1 Tax=Rubrobacter xylanophilus DSM 9941
           RepID=Q1AX10_RUBXD
          Length = 418

 Score =  471 bits (1212), Expect = e-131,   Method: Composition-based stats.
 Identities = 160/427 (37%), Positives = 230/427 (53%), Gaps = 20/427 (4%)

Query: 7   IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTAL 66
           +D     A +  + L RP    S  +   V  +++ V+ RGDEAL EY  +FD      L
Sbjct: 5   LDARGLDAREVVRRLRRPRGFLSREVRAAVRQVVEEVRERGDEALLEYGERFDGVRPDPL 64

Query: 67  KVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVAS 126
           +V  EEI  A   L  EL +A   A++N+  FH  +     ++E + G R  Q  RP+  
Sbjct: 65  RVPREEIERARAALPGELAEAFRTAIENVRRFHERELDRSWELE-RGGARLGQRVRPLRR 123

Query: 127 VGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQDVF 182
            G+Y+PGG     ST++M A PA +AG +++ +C+PP         +L  A L G+ +V+
Sbjct: 124 AGIYVPGGHGAYPSTLVMTAVPAQVAGVEELCVCTPPGPDGRANPRLLAVAGLLGIGEVY 183

Query: 183 NVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVI 242
             GGAQA+AA+AFGTESVP+VDKI GPGN +VT AK +V   +    +D P GPSE++V+
Sbjct: 184 AAGGAQAVAAMAFGTESVPRVDKIVGPGNDYVTAAKLEVFGEV---GVDAPQGPSELVVV 240

Query: 243 ADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL 302
           AD  A P+ VA DL++QAEH   +  +LLTP+  +A  V    E  L+  P         
Sbjct: 241 ADGSARPERVALDLMAQAEHLSGATSVLLTPSGALASGV----EPLLSGRPSEHIT---- 292

Query: 303 NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYA 362
               L++ +DL Q +EISN Y PEH+ +    A   ++ + +AG V +GD SP +  DYA
Sbjct: 293 ----LVLVRDLEQALEISNLYAPEHVHLNCEGAGAALERVEAAGLVAVGDLSPVALSDYA 348

Query: 363 SGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNA 422
           +G +H LPT G     S+LG  DF  R+     S+E    L   +E LA  E    H  +
Sbjct: 349 AGPSHALPTGGTARWASALGTHDFLTRINHMRFSREALRELGPHVERLARMEGFENHAAS 408

Query: 423 VTLRVNA 429
           V  R   
Sbjct: 409 VAARREK 415


>UniRef50_B0S9F2 Histidinol dehydrogenase n=6 Tax=Leptospira RepID=HISX_LEPBA
          Length = 430

 Score =  469 bits (1209), Expect = e-131,   Method: Composition-based stats.
 Identities = 167/423 (39%), Positives = 235/423 (55%), Gaps = 14/423 (3%)

Query: 18  RQLLMRPAISASESITRTVN---DILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIA 74
           ++L  R    A E +T   +    IL++V+ +GD+AL  Y+  FD   ++ L +  ++I 
Sbjct: 13  KELYSRFLQGAREDLTTATDRILPILESVRTQGDQALFSYTEMFDGIKLSQLTIDPKKIK 72

Query: 75  AASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGG 134
                + ++ K+A   A  NIE FH  QK      +   G R      P+ S+ +Y PGG
Sbjct: 73  T---NVDEKTKEAFLRAKSNIEAFHMEQKRESWS-KVIDGNRLGVKYTPIPSLAVYAPGG 128

Query: 135 SAPLFSTVLMLATPASIAGCKKVVLCSPPPIA--DEILY-AAQLCGVQDVFNVGGAQAIA 191
            A   S+VLM   PA IAG   + L +PP      EIL   AQ+  +  +  VGGAQ IA
Sbjct: 129 KALYPSSVLMGIIPAKIAGVPSIQLITPPQKDGIPEILVWLAQIMDIDRIVTVGGAQGIA 188

Query: 192 ALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDF 251
           A A+GTESVPK + I GPGNA+V  AK  +S +     I+ PAGPSEV +IAD  A P +
Sbjct: 189 AAAYGTESVPKSEFIVGPGNAYVAAAKSYLSGQ-GLIGIESPAGPSEVCIIADENANPKW 247

Query: 252 VASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQA--LNASRLIV 309
           +A D+LSQAEHG DS  ILLT    +A+RV+E +E   +E P+    +Q      S ++V
Sbjct: 248 IACDMLSQAEHGEDSSAILLTTDLTLAKRVSEELEIAFSERPKRLQMKQTAIYENSSILV 307

Query: 310 TKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVL 369
              L  C+  SN+  PEHL IQT++   +   I  AGSVFLG +SP + GDY SGTNH+L
Sbjct: 308 FPTLDDCIWFSNELAPEHLEIQTKDYESVFAKIEHAGSVFLGPYSPVAMGDYISGTNHIL 367

Query: 370 PTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERL-TAHKNAVTLRVN 428
           PT   +   SSLG+  F KR+T QE++KE    L   ++ ++  E L   H  +V +R  
Sbjct: 368 PTARGSRIYSSLGVDTFLKRVTFQEVTKESLENLYPFVKLMSELEGLDEEHGTSVKVRTR 427

Query: 429 ALK 431
             +
Sbjct: 428 QFQ 430


>UniRef50_A4QA32 Histidinol dehydrogenase n=16 Tax=cellular organisms
           RepID=A4QA32_CORGB
          Length = 408

 Score =  469 bits (1209), Expect = e-131,   Method: Composition-based stats.
 Identities = 137/395 (34%), Positives = 212/395 (53%), Gaps = 10/395 (2%)

Query: 39  ILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETF 98
           ++ +++ARGDEA+REYS KFD     +  V  E++    +R+ +++ + +      +   
Sbjct: 1   MIADIRARGDEAVREYSLKFDNYGPDSFLVQGEQLQEILDRVPEQVIEDIKFVQDQVRKV 60

Query: 99  HTAQKLP--PVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKK 156
             AQ       ++ET PGV   Q   P+ S G Y+PGG  PL ++  M    A +AG K+
Sbjct: 61  AQAQLQSMGEFEIETLPGVHIGQKNVPIDSAGAYVPGGKYPLLASAHMTILTAKVAGVKR 120

Query: 157 VVLCSP---PPIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAF 213
           VV C+P     + D  + A  L G  +++ +GG QAIAA+A GTE++  V  I GPGNAF
Sbjct: 121 VVACTPLIQGEVPDATVAAMHLAGADEIYLLGGIQAIAAMAIGTETIKPVSIIAGPGNAF 180

Query: 214 VTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTP 273
           V EAKRQ+   +    ID+ AGP+E L++AD    P   A DLLSQAEHGPDS  +L++ 
Sbjct: 181 VAEAKRQLFGEV---GIDLLAGPTETLIVADETTDPFIAAVDLLSQAEHGPDSPAVLIST 237

Query: 274 AADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQT 332
              +A +V + +   L E+P  + A  A  +   + V + +     +++++  EH+ I T
Sbjct: 238 DRAVAEQVIDHINELLPEMPTKDYAEVAWRDWGEVHVVESIEDAFSLADKFASEHVQILT 297

Query: 333 RNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTV 392
            + R  +D +   G++FLG+ +  S GD   GTNHVLPT G       L +  + + +T 
Sbjct: 298 ASPRRALDEMKHYGALFLGEGTCVSYGDKVIGTNHVLPTRGAARYTGGLWVGKYVRTITY 357

Query: 393 QELSKEGFSA-LASTIETLAAAERLTAHKNAVTLR 426
           QE++ E  SA         A  ER   H  +  +R
Sbjct: 358 QEVTNEDSSAFFGELCGRAARVERFEGHARSGDVR 392


>UniRef50_D2R570 Histidinol dehydrogenase n=1 Tax=Pirellula staleyi DSM 6068
           RepID=D2R570_9PLAN
          Length = 454

 Score =  468 bits (1205), Expect = e-130,   Method: Composition-based stats.
 Identities = 159/403 (39%), Positives = 227/403 (56%), Gaps = 12/403 (2%)

Query: 33  TRTVNDILDNVKARGDEALREYSAKFDKTTVTA--LKVSAEEIAAASERLSDELKQAMAV 90
           T  V  I  +V+ RG  A+ +YS K D+  +T   ++VS  E+ AA          A+A 
Sbjct: 57  TEVVETICRDVRERGIAAVLDYSKKLDRADLTPETIRVSQAELDAAHAAADPAFLAAIAR 116

Query: 91  AVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPAS 150
             +NI  F TA     V+V  + GV  +Q  +P+  +G+ +PGG+A   STVLM A PA 
Sbjct: 117 IQQNILEFQTAILHKEVEVR-RNGVVLRQRYQPLERIGICVPGGAAAYPSTVLMTAVPAQ 175

Query: 151 IAGCKKVVLCSPPPI----ADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKI 206
            AG  ++V+ +PP        ++L   +  GV +V+ +GGAQ +AALA+G E +PKVDKI
Sbjct: 176 AAGVSQIVVIAPPTDFGANNRDVLATCKAIGVTEVYRMGGAQGVAALAYGVEGIPKVDKI 235

Query: 207 FGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDS 266
            GPGN FV  AKR V   +D   ID  AGPSEV+VI+D     DF A+DLL+QAEH P +
Sbjct: 236 VGPGNLFVALAKRHVYGEVD---IDSIAGPSEVVVISDETTRADFTAADLLAQAEHAPGA 292

Query: 267 QVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVEISNQYGP 325
             IL+T +          +ER +  + R+E   Q+L +   LI+     +   ++++  P
Sbjct: 293 S-ILITWSRTALEATKRELERLVQTISRSELTLQSLRDFGCLILVDSPEEACRVTSEIAP 351

Query: 326 EHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLAD 385
           EHL I T NA  L+  I +AG+ FLG++SP + GDYA+G +HVLPT G     S L    
Sbjct: 352 EHLHIATENAGALLAKIRNAGATFLGNYSPVALGDYAAGPSHVLPTGGTARWASGLSANH 411

Query: 386 FQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVN 428
           F +  +V + S E    +A  I+ LA  E LTAH+ +V LRV 
Sbjct: 412 FLRSSSVIDYSAEALRDIAPAIQMLADKEGLTAHRLSVDLRVE 454


>UniRef50_Q2HFX2 Putative uncharacterized protein n=1 Tax=Chaetomium globosum
           RepID=Q2HFX2_CHAGB
          Length = 817

 Score =  468 bits (1205), Expect = e-130,   Method: Composition-based stats.
 Identities = 188/421 (44%), Positives = 245/421 (58%), Gaps = 34/421 (8%)

Query: 24  PAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALK--------VSAEEIAA 75
           P  +A E IT  V D+    +   DEALR  S K   T +  +         V       
Sbjct: 419 PKEAAPERITMKVFDMATASRKELDEALRRPSQKSSDTIMKIITPIIDDTSPVLKAPFPE 478

Query: 76  ASERLSDELKQAMAVAVKNIETFHTAQKL-PPVDVETQPGVRCQQVTRPVASVGLYIPGG 134
           +  +L  E  +AM V+ +NI  FH AQK   P+ VET PGV C + +RP  +VGLY+PGG
Sbjct: 479 SLMQLPTETIKAMDVSFENIRKFHAAQKEEKPLQVETIPGVVCSRFSRPPEAVGLYVPGG 538

Query: 135 SAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVFNVGGAQAIAALA 194
           +A L ST  ML  PA +A CKK+VL SPP                       + A+AA+A
Sbjct: 539 TAVLPSTAFMLGVPAMVAACKKIVLASPP----------------------RSDAVAAMA 576

Query: 195 FGTESVPKVDKIFGPGNAFVTEAKRQVSQRLD-GAAIDMPAGPSEVLVIADSGATPDFVA 253
           +GTESV KVDKI GPGN FVT AK  VS   + G  IDMPAGPSEVLVIAD  A P FVA
Sbjct: 577 YGTESVSKVDKILGPGNQFVTAAKMFVSNDTNAGVGIDMPAGPSEVLVIADKDANPAFVA 636

Query: 254 SDLLSQAEHGPDSQVILLTPAADMAR--RVAEAVERQLAELPRAETARQALNASRLIVTK 311
           SDLLSQAEHG DSQVIL+      A+   + + V +Q   LPR +  R ++  S  +  K
Sbjct: 637 SDLLSQAEHGVDSQVILIAIDLTDAQLLAIEDEVHKQAMALPRVDIVRGSIAHSLTVRVK 696

Query: 312 DLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPT 371
            + + +EISNQY PEHLI+Q ++A  +VD + +AGSVF+G+W+PES GDY++G NH LPT
Sbjct: 697 TVDEAMEISNQYAPEHLILQIKDAESVVDKVMNAGSVFIGEWTPESVGDYSAGVNHSLPT 756

Query: 372 YGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNALK 431
           YGY    S + LA F K +T   L+ EG   +   +  LA  E L AH+ AV++R+  + 
Sbjct: 757 YGYAKQYSGVNLASFVKHITSSNLTAEGLRNVGEAVMQLAKVEELEAHRRAVSIRLAHMD 816

Query: 432 E 432
           +
Sbjct: 817 Q 817


>UniRef50_D2RSH8 Histidinol dehydrogenase n=1 Tax=Haloterrigena turkmenica DSM 5511
           RepID=D2RSH8_9EURY
          Length = 432

 Score =  468 bits (1205), Expect = e-130,   Method: Composition-based stats.
 Identities = 161/422 (38%), Positives = 239/422 (56%), Gaps = 10/422 (2%)

Query: 11  SCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSA 70
                 +     R   +  ++I+  V +I+D V   GD A+RE++++FD   +  + ++ 
Sbjct: 10  DLGPADRTAFFDR--DAGIDAISDDVREIVDRVHEEGDVAVREFTSEFDDVELGNIDIT- 66

Query: 71  EEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLY 130
           +    A E L  ++++A+  A  N+  FH AQ       E  PG    +  RP+  VG+Y
Sbjct: 67  DACERAYEDLEGDVREAIETAADNVREFHEAQLPEDWRREFGPGRELGRRFRPIERVGVY 126

Query: 131 IPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP--PIADEILYAAQLCGVQDVFNVGGAQ 188
           +PGGSA   S+ +M   PA +AG   V + +PP   +    L A  + G   V++VGGAQ
Sbjct: 127 VPGGSAAYPSSAIMGVVPAVVAGVDHVAVVTPPADELNPVTLAAIHVAGADAVYSVGGAQ 186

Query: 189 AIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGAT 248
           AIA LA+GTE++ +V KI GPGN +VT AK  V   ++   ID  AGPSEV+V+AD  A 
Sbjct: 187 AIAGLAYGTETITRVQKIVGPGNKWVTAAKAAVRGDVE---IDFLAGPSEVVVVADETAD 243

Query: 249 PDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNA--SR 306
           PD VA++L++QAEH P++ V+ +T  A+ A  VA AV+ Q     R +  R A     S 
Sbjct: 244 PDLVAAELVAQAEHDPNASVVAVTDDAETADAVAAAVDGQTEARKREDVIRGAFENDASG 303

Query: 307 LIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTN 366
           +++ + +++ +  + +Y PEHL I   +   +++ I SAGSVFLG  +P +AGDYASGTN
Sbjct: 304 VLLARSMSEAILFTEEYAPEHLSIIADDEESILERIDSAGSVFLGPNTPVAAGDYASGTN 363

Query: 367 HVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
           HVLPT G       L +  F +  TVQ LS EG + +  TI TLA AE L AH  +V  R
Sbjct: 364 HVLPTNGGARVTGGLSIETFLRSTTVQRLSAEGLADIGDTITTLADAEGLEAHAESVRQR 423

Query: 427 VN 428
           + 
Sbjct: 424 LE 425


>UniRef50_B6A0U7 Histidinol dehydrogenase n=1 Tax=Rhizobium leguminosarum bv.
           trifolii WSM2304 RepID=B6A0U7_RHILW
          Length = 448

 Score =  467 bits (1203), Expect = e-130,   Method: Composition-based stats.
 Identities = 164/442 (37%), Positives = 237/442 (53%), Gaps = 16/442 (3%)

Query: 5   TIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV- 63
           +I   ++    Q++ LL R     S  I + VN I++ V+  GD AL +++ +FDK  V 
Sbjct: 7   SIHTLSALDDAQRKALLQRTESDLSAFIDK-VNPIIEAVRIDGDAALADFARQFDKAQVA 65

Query: 64  -TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDV-ETQPGVRCQQVT 121
              L+ + EE +AA   +  EL   +  A  NI  FH  Q    + + ET  GV      
Sbjct: 66  ADQLRATTEEFSAARASIDPELITTLEFAAGNIRHFHEKQMPETLVLHETHRGVLVGDRW 125

Query: 122 RPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCG 177
             + SV  Y+P G     S+VLM A PA +AG +KVV+ +PP     +    L AA++ G
Sbjct: 126 NAIDSVACYVPRGKGSFPSSVLMTAIPAKVAGVRKVVIITPPGPDGTVDPATLVAAEIAG 185

Query: 178 VQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPS 237
           V DVF  GGAQAIAA+AFGT++VPK DK+ GPG+ +V  AK+Q+S  +D  +   PAGPS
Sbjct: 186 VSDVFKCGGAQAIAAVAFGTQTVPKCDKVVGPGSPWVVAAKKQLSSLIDPGS---PAGPS 242

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELP--RA 295
           E+++ +D     + VA DL  ++EHGPDS V  +T  AD A  VA  V    + +   RA
Sbjct: 243 ELIIFSDGSVPAELVALDLCVESEHGPDSSVFFVTDNADFANAVASCVPALWSRMGNIRA 302

Query: 296 ETARQALNA--SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDW 353
           + ++  L+     +++ +  A  +   N Y PEHL +   NA + +     AG + LG  
Sbjct: 303 QYSKTVLSGPRGGIVIARTRADALAFVNDYAPEHLAVLADNAWQYLACFEHAGEILLGPH 362

Query: 354 SPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAA 413
           S  S  ++  G +HVLPT G   T S L + DF KR ++  LSKE +   A+  E LA  
Sbjct: 363 SAISVANFVLGPSHVLPTGGAAKTTSPLSVFDFLKRTSIASLSKEAYGGFAAHAERLARY 422

Query: 414 ERLTAHKNAV-TLRVNALKEQA 434
           E    H NAV T+R  AL+  A
Sbjct: 423 EGFDGHANAVSTIRDEALRSAA 444


>UniRef50_Q3IQR5 Histidinol dehydrogenase n=10 Tax=Halobacteriaceae RepID=HISX_NATPD
          Length = 422

 Score =  465 bits (1198), Expect = e-129,   Method: Composition-based stats.
 Identities = 169/422 (40%), Positives = 237/422 (56%), Gaps = 11/422 (2%)

Query: 11  SCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSA 70
             + E +  L  R   +  E    +V DI+  V+  GD ALR Y+ +FD   +  L V+ 
Sbjct: 8   DLSPEARAALFER--DAGIEDARESVRDIIGRVREEGDVALRSYAKEFDDVDIGTLAVT- 64

Query: 71  EEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLY 130
           +E   A + L D+L+ A+  A +NI TFH  Q       E   G    +  RP+  VG+Y
Sbjct: 65  DEAERAYDDLDDDLRDAIETAAENIRTFHERQVPDDW-REQFDGRELGRRYRPLERVGVY 123

Query: 131 IPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP--PIADEILYAAQLCGVQDVFNVGGAQ 188
            PGG+A   S+VLM   PA +AG   V + +PP   +    L AA + G   V+ VGGAQ
Sbjct: 124 APGGTAAYPSSVLMGVIPAVVAGVDHVAVATPPAEELPAATLAAAHVAGADAVYQVGGAQ 183

Query: 189 AIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGAT 248
           AIAALA+GTESV  V K+ GPGN +VT AK +V   ++   ID  AGPSE+LV+ D  A 
Sbjct: 184 AIAALAYGTESVSAVQKVVGPGNRWVTAAKAEVRGDVE---IDFLAGPSELLVVCDDTAD 240

Query: 249 PDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNA--SR 306
           P+ +A+D+++QAEH P++ V+ ++     A  VA+A ERQ     R E    AL    S 
Sbjct: 241 PELIAADMVAQAEHDPNASVVCVSDDEATAEAVADACERQATARERTEAIESALENDASA 300

Query: 307 LIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTN 366
           ++  + +++ V  + +Y  EHL I   +   L+D I SAGSVFLG +SP + GDYASGTN
Sbjct: 301 VLCARSMSEAVLFAEEYAAEHLSIVAADEEALLDRIDSAGSVFLGGFSPVAVGDYASGTN 360

Query: 367 HVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
           HVLPT G       L +  F +  TVQ+L ++  S+L  T+ TLA AE L AH  +V  R
Sbjct: 361 HVLPTGGLAKVAGGLSVDHFVRSTTVQKLDEDALSSLRETVTTLARAEGLEAHAESVDKR 420

Query: 427 VN 428
            +
Sbjct: 421 FD 422


>UniRef50_D1B7M0 Histidinol dehydrogenase n=2 Tax=Bacteria RepID=D1B7M0_THEAS
          Length = 424

 Score =  465 bits (1197), Expect = e-129,   Method: Composition-based stats.
 Identities = 162/417 (38%), Positives = 236/417 (56%), Gaps = 13/417 (3%)

Query: 19  QLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASE 78
           ++  R + S    ++  V  I+D V   GD A+ E S   D+++  ++ V  EE+  A  
Sbjct: 8   RVKDRASSSDLYGVSHEVRRIIDWVVLHGDRAVLEGSRLHDRSSRDSILVPVEELQRAHR 67

Query: 79  RLSDELKQAMAVAVKNIETFHTAQK---LPPVDVETQPGVRCQQVTRPVASVGLYIPGGS 135
            +  EL +A+  A  N+ETF   QK   +P  + E + GV       PV S G+YIPGGS
Sbjct: 68  SMDPELLEAVRYAASNVETFAQRQKGALMPLEESEVRDGVYLGHRVVPVDSCGIYIPGGS 127

Query: 136 APLFSTVLMLATPASIAGCKKVVLCSP-----PPIADEILYAAQLCGVQDVFNVGGAQAI 190
            PL ST +MLA PA +AG  ++  C+P           +L      GV +V+  GGA A+
Sbjct: 128 YPLISTAVMLAVPARVAGVGRICACTPVRRGTNSPDPSVLGTLYELGVTEVYAAGGAYAV 187

Query: 191 AALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPD 250
           AA+A GTES+P VD I GPGN +VTEAKRQ   ++    ID  AGPSEVL+IA  G  PD
Sbjct: 188 AAMAHGTESIPPVDVIVGPGNKYVTEAKRQCFGKV---GIDFVAGPSEVLIIAQEG-DPD 243

Query: 251 FVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIV 309
           F+A DLL+QAEH PD++ +L+T +  +AR+V + VE  L E+  +  AR +  +   ++ 
Sbjct: 244 FIAWDLLAQAEHDPDAKGVLVTTSPALARQVMDRVETILGEIVTSPVARSSWEDHGEVLA 303

Query: 310 TKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVL 369
            + + + VE SN+  PEHL +  ++    +  + + G++F+G+ S E  GDYASG+NH L
Sbjct: 304 AEGMDEAVEFSNRMAPEHLELMVQDPDRWIPRLRNYGALFIGEHSAEVFGDYASGSNHTL 363

Query: 370 PTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
           PT G +     L +  F K +T Q +++EG   LA     LA AE L AH+ A   R
Sbjct: 364 PTAGASRYTGGLWVGTFLKVLTSQRVTREGARELARVSALLAQAEGLMAHRGAALAR 420


>UniRef50_B2UMH6 Histidinol dehydrogenase n=3 Tax=Verrucomicrobia RepID=B2UMH6_AKKM8
          Length = 432

 Score =  463 bits (1191), Expect = e-129,   Method: Composition-based stats.
 Identities = 159/424 (37%), Positives = 242/424 (57%), Gaps = 12/424 (2%)

Query: 10  NSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV--TALK 67
           ++C  E +R++  R     S  +  TVN I+ +V  RGDEAL +Y+A+FDK  +  ++L 
Sbjct: 8   DTCFDEMKRRMNRRALPEDS--VRDTVNAIIRDVSVRGDEALFDYAARFDKAHLDSSSLF 65

Query: 68  VSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASV 127
           V+  E+A A   + + +K+A+AV++ NI  F    +          GV   +   P   V
Sbjct: 66  VTEAELAEAEAMVEESVKEAIAVSLANIHYFSDRSRRRDWSGVNAQGVEVAERFLPYDRV 125

Query: 128 GLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSP----PPIADEILYAAQLCGVQDVFN 183
           G+YIPGG APL ST +M    A  AG +++V  +P      +   +LYA +  G  ++  
Sbjct: 126 GIYIPGGKAPLVSTSIMTGGFAQAAGVREIVAATPCGPDGRVNPALLYALKASGATEIVK 185

Query: 184 VGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIA 243
           +GGAQAIAALA GTESV  V+KIFGPGN FV EAKRQ+   +   AID+  GPSEV+V+A
Sbjct: 186 IGGAQAIAALALGTESVRPVEKIFGPGNRFVVEAKRQL---VGAVAIDLLPGPSEVMVLA 242

Query: 244 DSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALN 303
           D  A  +F+A+DLL+Q EHGPDS V+ +T +  +  +V   VERQ A L R    R+ L+
Sbjct: 243 DDTADAEFLAADLLAQGEHGPDSVVVFVTTSKALLEQVEAEVERQAALLSRGSIIREVLD 302

Query: 304 ASRL-IVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYA 362
                 +   + + VE+ N + PEHL++ TR+   +++ I +AG+++ G  S  + GD+ 
Sbjct: 303 KHAYGFLVSSIQEGVELVNAFAPEHLVLVTRDEEAVLNGIRTAGAIYAGSLSTVACGDFL 362

Query: 363 SGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNA 422
           +G +H LPT G   + S L    FQ+R +V  + +      A  +   A  E L AH ++
Sbjct: 363 AGPSHTLPTGGAGKSFSGLRADQFQRRTSVVRMDRNAVLNSAPYVAEFARVEGLDAHNHS 422

Query: 423 VTLR 426
           + +R
Sbjct: 423 IQVR 426


>UniRef50_C1FAE2 Histidinol dehydrogenase n=1 Tax=Acidobacterium capsulatum ATCC
           51196 RepID=C1FAE2_ACIC5
          Length = 428

 Score =  460 bits (1185), Expect = e-128,   Method: Composition-based stats.
 Identities = 166/423 (39%), Positives = 237/423 (56%), Gaps = 16/423 (3%)

Query: 14  AEQQRQLLMR---PAISASESITRTVNDILDNVKARGDEALREYSAKFDK-TTVTALKVS 69
           A+  +  L R    + ++ E        I+  V+  GD AL  Y AKFD       L++ 
Sbjct: 11  AQAAQDFLSRLLTGSEASYERALPAAQRIVQGVRRGGDAALLRYRAKFDGIAASEPLRIP 70

Query: 70  AEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGL 129
           AEE+ AA +  + ELK A+  A KNI  F   Q+     ++  PGV   Q   P+ +VG 
Sbjct: 71  AEEMEAAWKATTAELKAALKQAAKNIRRFAQKQRPRDFTLQMAPGVTAGQKVIPLEAVGC 130

Query: 130 YIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVFNVGGAQA 189
           Y+P G  PL ST+LM A PA +AG +++V  SP P A E L AA + GV + + +GGAQA
Sbjct: 131 YVPSGRYPLPSTLLMTAIPAQVAGVRRIVAVSPRP-AKETLAAAHMLGVAEFYRIGGAQA 189

Query: 190 IAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATP 249
           +AALA+GT S+ +V KI GPGNA+VT AK+ VS       IDM AGP+E+ VIA    T 
Sbjct: 190 VAALAYGTASIERVGKIVGPGNAYVTAAKKAVSFD---CGIDMLAGPTEI-VIASENGTV 245

Query: 250 DFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLI 308
           + +A+DL++QAEH PD+  IL+T  A + R VA   + +         A+Q++     +I
Sbjct: 246 EGIAADLVAQAEHDPDAIAILVTSNAALGRAVAAKTKLRAQS---NAIAKQSIAANGAVI 302

Query: 309 VTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHV 368
           +T+D+ +   ++NQ   EHL   T ++   +  + +AGSVF+G WS +  GDY SG NH 
Sbjct: 303 LTRDVEEARMLTNQLAAEHL---TVDSSADLAWVRNAGSVFVGRWSSQPLGDYVSGPNHT 359

Query: 369 LPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVN 428
           LPT G       L + D+ K +TVQE S  G   L  +   LA AE L  H +AV +R+ 
Sbjct: 360 LPTSGLARLRGGLSVMDYLKLVTVQEYSATGVRQLGPSAVALAEAEGLVGHADAVRVRLQ 419

Query: 429 ALK 431
           + K
Sbjct: 420 SAK 422


>UniRef50_C0GVA3 Histidinol dehydrogenase n=1 Tax=Desulfonatronospira thiodismutans
           ASO3-1 RepID=C0GVA3_9DELT
          Length = 436

 Score =  459 bits (1182), Expect = e-128,   Method: Composition-based stats.
 Identities = 132/408 (32%), Positives = 202/408 (49%), Gaps = 8/408 (1%)

Query: 29  SESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAM 88
           +  I   V  +LD+++ RG+ A+RE +AK+D  + T   +  E+       + +++K  +
Sbjct: 15  NSRIREAVTFLLDDIRTRGEPAVREMAAKYDGWS-TDFVLQEEKKERLIAMVPEQVKTDI 73

Query: 89  AVAVKNIETFHTAQKL--PPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLA 146
             A   +  F   Q+      +V   PGVR  Q   PV   G Y+PGG      + +M  
Sbjct: 74  RFAHDQVFNFARMQRQSIQDFEVRPHPGVRLGQRVLPVDVAGCYVPGGRFAHACSAIMSV 133

Query: 147 TPASIAGCKKVVLCSPP---PIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKV 203
             A  AG   VV CSPP    IA  + +A  L G   +  +GG Q +AA+A+G  +    
Sbjct: 134 ATAKAAGVPFVVACSPPREESIAPAVAFAMDLAGADVILELGGVQGVAAMAYGYFTNRPA 193

Query: 204 DKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHG 263
           D + GPGNA+V EAK  ++       ID+ AGP+E  +IAD  A P  +A DL+SQAEHG
Sbjct: 194 DILVGPGNAYVAEAKALLAGD-GTCGIDVYAGPTESAIIADRSADPMTIAIDLVSQAEHG 252

Query: 264 PDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVEISNQ 322
           PDS V L T   D+A +V   V R +A++P     + A  +   +I+  +  +   + + 
Sbjct: 253 PDSPVWLFTDCRDLAYQVLNLVPRVIADMPDPHVPKTAWADFGEIILCNNRDEICRVCDT 312

Query: 323 YGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLG 382
           Y PEH+ I   +    ++S+ S GS+FLG+ S  + GD  SGTNH+LPT         L 
Sbjct: 313 YAPEHVQILAADPDWWLESLRSYGSLFLGEGSSVAHGDKCSGTNHILPTRKAAQHSGGLS 372

Query: 383 LADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNAL 430
           +  F K  T QE+  E     ++    L+  E +  H  +   R+   
Sbjct: 373 VHKFLKISTYQEIDTEASKRFSAVASRLSRVEGMEGHARSCDWRLTKF 420


>UniRef50_Q5YYQ0 Histidinol dehydrogenase n=8 Tax=Actinomycetales RepID=HISX_NOCFA
          Length = 445

 Score =  459 bits (1182), Expect = e-128,   Method: Composition-based stats.
 Identities = 159/434 (36%), Positives = 233/434 (53%), Gaps = 17/434 (3%)

Query: 10  NSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVS 69
            + +  + R  L R  +   +S+   V  +++ V+ RG  A  E+  KFD      ++V 
Sbjct: 15  RTPSTAELRAALPRGGVDV-DSVLHHVRPVVEAVRERGAAAALEFGEKFDGVVPATVRVP 73

Query: 70  AEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGL 129
           A E+A A + L   ++ A+  ++      H  Q+      E  PG    +   PVA VGL
Sbjct: 74  AAELARALDELDPAVRAALEESIARARRVHADQRRTDTTTEVVPGGTVTERWVPVARVGL 133

Query: 130 YIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIA------DEILYAAQLCGVQDVFN 183
           Y+PGG+A   S+V+M   PA  AG   +V+ SPP           IL AA L GV++V+ 
Sbjct: 134 YVPGGNAVYPSSVVMNVVPAQTAGVGSLVVASPPQANFGGLPHPTILAAAALLGVEEVWA 193

Query: 184 VGGAQAIAALAFG---TESVP--KVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSE 238
           VGGAQA+A L++G   T+  P   VD I GPGN +VT AKR     +    ID  AGP+E
Sbjct: 194 VGGAQAVALLSYGGTDTDGAPLDPVDLITGPGNIYVTAAKRLCRGLV---GIDAEAGPTE 250

Query: 239 VLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETA 298
           + ++AD+ A P  VA+DL+SQAEH   +  +L+T +  +A  V  A+  QLA +  AE  
Sbjct: 251 IAILADATADPAHVAADLISQAEHDVLAASVLVTDSVALADAVDAALTAQLAVVKHAERV 310

Query: 299 RQAL--NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPE 356
           R AL    S  ++  D+ Q + + + Y  EHL IQT +A  +   + SAG+VF+G ++P 
Sbjct: 311 RTALTGKQSGTVLVDDITQGLRVVDAYAAEHLEIQTADASAVAARVRSAGAVFVGPYAPV 370

Query: 357 SAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERL 416
           S GDY +G+NHVLPT G     S L +  F + + V E ++     +A  +  LA AE L
Sbjct: 371 SLGDYCAGSNHVLPTAGCARHSSGLSVQTFLRGIHVVEYTEAALKDVAGHVVALADAEDL 430

Query: 417 TAHKNAVTLRVNAL 430
            AH  AVT+R  AL
Sbjct: 431 PAHGQAVTVRFEAL 444


>UniRef50_Q82AA6 Histidinol dehydrogenase n=29 Tax=Actinobacteridae RepID=HISX_STRAW
          Length = 441

 Score =  459 bits (1181), Expect = e-127,   Method: Composition-based stats.
 Identities = 149/423 (35%), Positives = 228/423 (53%), Gaps = 13/423 (3%)

Query: 14  AEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEI 73
               R LL R     S ++ + V  I + V  RGD AL +++ KFD   + +++V A  +
Sbjct: 15  GSALRDLLPRADFDVSAALEK-VRPICEAVHHRGDAALIDFAEKFDGVRLESVRVPARAL 73

Query: 74  AAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPG 133
           A A E+L   ++ A+  +++     H  Q+      +  PG    +   PV  VGLY PG
Sbjct: 74  ADALEQLDPAVRAALEESIRRARLVHREQRRTTHTTQVVPGGSVTEKWVPVDRVGLYAPG 133

Query: 134 GSAPLFSTVLMLATPASIAGCKKVVLCSPPPI------ADEILYAAQLCGVQDVFNVGGA 187
           G +   S+V+M   PA  AG + + L SP            IL A  L GV +V+  GGA
Sbjct: 134 GRSVYPSSVVMNVVPAQEAGVESIALASPAQAEFGGLPHPTILAACALLGVDEVYAAGGA 193

Query: 188 QAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGA 247
            A+A  A+GTES    D + GPGN +V  AKR  + ++    ID  AGP+E+ V+ADS A
Sbjct: 194 TAVAMFAYGTESCAPADMVTGPGNIWVAAAKRYFTGKI---GIDAEAGPTEIAVLADSTA 250

Query: 248 TPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPR-AETARQALN--A 304
            P  VASDL+SQAEH P +  +L+T + ++A  V + +E Q+A      +    AL    
Sbjct: 251 DPVHVASDLISQAEHDPLAAAVLVTDSVELADAVEKELEPQVAATKHIDDRIVPALKGRQ 310

Query: 305 SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASG 364
           S +++   + + + + + YG EHL IQT +A  + D + +AG++F+G W+P S GDYA+G
Sbjct: 311 SAIVLVDGVDEGLRVVDAYGAEHLEIQTADAAAVADRVRNAGAIFIGPWAPVSLGDYAAG 370

Query: 365 TNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVT 424
           +NHVLPT G     S L +  F + + + + +K+  + +A  + TLA AE L AH  A+ 
Sbjct: 371 SNHVLPTGGCACHSSGLSVQSFLRGIHIVDYTKDALADVAHHVVTLAEAEDLPAHGAAIK 430

Query: 425 LRV 427
            R 
Sbjct: 431 ARF 433


>UniRef50_C0G418 Histidinol dehydrogenase n=2 Tax=Rhizobiales RepID=C0G418_9RHIZ
          Length = 444

 Score =  458 bits (1180), Expect = e-127,   Method: Composition-based stats.
 Identities = 155/411 (37%), Positives = 218/411 (53%), Gaps = 14/411 (3%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
             T +       EQ+    +      SE + R V +I+D V+  GD AL +YS +FD+  
Sbjct: 1   MVTTLRQTDPDFEQKFAAFLSGKREVSEDVDRAVREIVDRVRREGDSALLDYSRRFDRID 60

Query: 63  VTA--LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQV 120
           +    + V+  EI AA +       +A+ +A   IE  H  Q           GV     
Sbjct: 61  LEKTGIAVTEAEIDAAFDAAPASTVEALKLARDRIEKHHARQLPKDDRYTDALGVELGSR 120

Query: 121 TRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCG 177
              + +VGLY+PGG+A   S+VLM A PA +AG  ++V+  P P   +   +L AA+L G
Sbjct: 121 WTAIEAVGLYVPGGTASYPSSVLMNAMPAKVAGVDRIVMVVPAPDGNLNPLVLVAARLAG 180

Query: 178 VQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPS 237
           V +++ VGGAQAIAALA+GTE++  V KI GPGNA+V  AKR V   +    IDM AGPS
Sbjct: 181 VSEIYRVGGAQAIAALAYGTETIRPVAKIVGPGNAYVAAAKRIVFGTV---GIDMIAGPS 237

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAET 297
           EVL++AD    PD++A+DLL+QAEH   +Q IL+T     A  V EAVERQL  L R ET
Sbjct: 238 EVLIVADKDNNPDWIAADLLAQAEHDTAAQSILMTNDEAFAHAVEEAVERQLHTLARTET 297

Query: 298 ARQAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPE 356
           A  +  +   +I+ KD    + ++N+   EHL I   +A   V  I +AGS+F+G ++P 
Sbjct: 298 ASASWRDFGAVILVKDFEDAIPLANRIAAEHLEIAVADAEAFVPRIRNAGSIFIGGYTPG 357

Query: 357 SAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQEL-SKEGFSALAST 406
           S      G   + P     A C  L L  F  R+    L S+ G  A + T
Sbjct: 358 SDRRLCGG---LQPCAANGALCPFL-LRPFGARLYEAHLASQAGLRAASRT 404


>UniRef50_Q5JFR5 Histidinol dehydrogenase n=9 Tax=cellular organisms
           RepID=HISX_PYRKO
          Length = 376

 Score =  458 bits (1179), Expect = e-127,   Method: Composition-based stats.
 Identities = 151/400 (37%), Positives = 229/400 (57%), Gaps = 29/400 (7%)

Query: 30  ESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAMA 89
           + +   V +IL++++ RG EALREYS +FD  +    +VS  E   A E + +E K+ + 
Sbjct: 2   KGLEEYVREILEDIRRRGLEALREYSERFDNYS-GPFRVSEGEFEEAEELVPEEDKRVIE 60

Query: 90  VAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPA 149
             ++ +  +H  Q    V++  + G     + RP+  +G+Y+PGG  PL ST++M+  PA
Sbjct: 61  ETMERLWEYHARQ-FRDVELYIKRGSLYGLIYRPIGRIGIYVPGGK-PLPSTLMMVGIPA 118

Query: 150 SIAGCKKVVLCSPPP---IADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKI 206
            IAG +++ + +PP    +   +LY A+L G+++V+ +GG  AIAA+A+G   + +VDKI
Sbjct: 119 RIAGVREIAVTTPPKDGKVNPYVLYVAKLLGIEEVYKLGGVGAIAAMAYGV-GMRRVDKI 177

Query: 207 FGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDS 266
           FGPGN FV EAKRQV   +    ID  AGPSE+ VIAD  A  D+V +DLLSQ EHG DS
Sbjct: 178 FGPGNRFVNEAKRQVFGIV---GIDSLAGPSEIAVIADESADKDYVLADLLSQLEHGKDS 234

Query: 267 QVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQCVEISNQYGPE 326
           +  LLT + ++A               R            +++ ++L +C E +N+  PE
Sbjct: 235 KAWLLTTSRELAD-----------YCSREGI--------EVLLCRNLEECAEKANEIAPE 275

Query: 327 HLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADF 386
           HL I T N  ELVD I +AG+++LG ++P  A DY  G NHVLPT G       L + DF
Sbjct: 276 HLEIITENPEELVDLIENAGAIYLGPYTPVPAADYFLGVNHVLPTGGAARFSGVLTVMDF 335

Query: 387 QKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
            K +T+  +S+E F A       LA  E + AH+ ++ +R
Sbjct: 336 MKPITLARVSREEFLAYRRLGMRLAEIEGMEAHRRSLEVR 375


>UniRef50_Q1D4L9 Histidinol dehydrogenase n=2 Tax=Cystobacterineae
           RepID=Q1D4L9_MYXXD
          Length = 437

 Score =  455 bits (1172), Expect = e-126,   Method: Composition-based stats.
 Identities = 172/422 (40%), Positives = 243/422 (57%), Gaps = 9/422 (2%)

Query: 10  NSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVS 69
           ++   E  R+LL R A  +   +   V +I+  V+A GD+AL E + +FD+  +TAL+V 
Sbjct: 17  SALAREDVRRLLDR-ATGSDARVALRVREIIARVRAEGDQALFELARQFDRVELTALEVP 75

Query: 70  AEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGL 129
            E  AAA   L   ++ A+A A +NI   H  QK   V+VET+PGV   +   P+  VG+
Sbjct: 76  REVCAAALAGLEPSVRDALARAARNIALAHAPQKPQWVEVETEPGVLVGRRPDPLGRVGV 135

Query: 130 YIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQDVFNVG 185
           Y PGG A   S+VLM   PA +AG  +V++CSPP         +L AA L G   VF++G
Sbjct: 136 YAPGGRAVYPSSVLMGVVPAKVAGVGEVIVCSPPGPDGLPHPSVLAAASLAGADRVFSLG 195

Query: 186 GAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADS 245
           GA A+AA+A GTESVP+VD+I GPGNA+V EAK QV   +   AI+ PAGPSE+LV+AD 
Sbjct: 196 GAGAVAAMAHGTESVPRVDRIVGPGNAYVAEAKLQV---VGAVAIEAPAGPSEILVVADD 252

Query: 246 GATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNA- 304
            A P  VA ++L+QAEH P++  + L     +A  +A  VERQ     R E    AL + 
Sbjct: 253 TANPAAVAREMLAQAEHDPEAACVTLALGDALADAIAAEVERQAERAKRWEIVTSALGSR 312

Query: 305 SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASG 364
             ++    L +       + PEHL+I T + RE +  + +AG+VFLG+ S  + GDY +G
Sbjct: 313 GAVLTVASLEEAWPFVADFAPEHLLIATASPREDLGQVRNAGTVFLGERSSVAYGDYMTG 372

Query: 365 TNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVT 424
           +NHVLPT G     S L L DF +  T Q ++    ++LA  +  LA +E L AH +A  
Sbjct: 373 SNHVLPTAGLARAYSGLNLLDFYRWTTYQRVAPTAAASLAEDVGRLADSEGLFAHADAAR 432

Query: 425 LR 426
             
Sbjct: 433 AW 434


>UniRef50_B8E2C3 Histidinol dehydrogenase n=1 Tax=Dictyoglomus turgidum DSM 6724
           RepID=B8E2C3_DICTD
          Length = 417

 Score =  454 bits (1169), Expect = e-126,   Method: Composition-based stats.
 Identities = 126/411 (30%), Positives = 214/411 (52%), Gaps = 19/411 (4%)

Query: 21  LMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA--LKVSAEEIAAASE 78
           L+R   S  + + + V+ I++ ++ +GD AL  +S KFD         K+S  EI     
Sbjct: 14  LLRMEESKVKEVEKEVDFIVEEIRTKGDLALHNFSLKFDNYDSKKYGFKISVPEID---- 69

Query: 79  RLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPL 138
            LS++   A+ V ++ ++ ++  +       +    +   Q+  PV SV LY+PGG A  
Sbjct: 70  -LSNDFATAIKVMIERVKNYYIHEYKNSWFYKDGESI-LGQLIVPVDSVLLYVPGGKASY 127

Query: 139 FSTVLMLATPASIAGCKKVVLCSPPPI--ADEILYAAQLCGVQDVFNVGGAQAIAALAFG 196
            STV+M   PA IAG K + + +PP       +LY  +L G+++++ +GGA AI+A A+G
Sbjct: 128 PSTVVMGLIPAMIAGVKNLYVTTPPSKREDRNLLYTLRLLGIKELYVLGGAHAISAFAYG 187

Query: 197 TESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIAD---SGATPDFVA 253
           TES+PKVD I GPGN +V  AK++V   ++   ID   GPSE+LV  +          + 
Sbjct: 188 TESIPKVDMIIGPGNLYVALAKKRVFGDVN---IDGIFGPSEILVWINYRGKDLNLRKIV 244

Query: 254 SDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDL 313
            D L+Q EH P  +  ++ P  ++  +V   ++ ++    R +  ++A+  S LI+ +D 
Sbjct: 245 CDFLAQLEHSPYDRGWMILP-EELLDKVMGLIKEEVEGSGRGDILKEAIKNSFLIIEEDE 303

Query: 314 AQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYG 373
            + + + NQ  PEHL I   +    +  I +AG++F+   S    GD+ +G +H+LPT G
Sbjct: 304 ERAINLINQIAPEHLEIIDFSGERHIPYIKNAGAIFINHSS--IFGDFIAGPSHILPTGG 361

Query: 374 YTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVT 424
                S L +  F KR++  +LS +    LA     +A  E    H+ ++ 
Sbjct: 362 SAKFSSGLSVNSFLKRISFVKLSAKEQKILAEYGSIIAREEGFYMHEKSLR 412


>UniRef50_Q1IKB6 Histidinol dehydrogenase n=1 Tax=Candidatus Koribacter versatilis
           Ellin345 RepID=Q1IKB6_ACIBL
          Length = 415

 Score =  453 bits (1166), Expect = e-126,   Method: Composition-based stats.
 Identities = 177/408 (43%), Positives = 249/408 (61%), Gaps = 14/408 (3%)

Query: 21  LMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKT-TVTALKVSAEEIAAASER 79
           L    ++ +  +   V  I+ +V+  GD ALR Y++K D      AL+VS EE+ +A + 
Sbjct: 16  LAARGMADASRVEPVVRKIVVDVRKNGDAALRRYASKLDGLGKTAALRVSTEELKSAWDA 75

Query: 80  LSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLF 139
              E KQA+  A KNIE F   Q       +   G+   Q+ RP+ SVG Y+PGG  PL 
Sbjct: 76  TRSEFKQAIRAAAKNIERFARWQMPKSWTRDAGDGIELGQIIRPIESVGCYVPGGRYPLP 135

Query: 140 STVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTES 199
           STVLM   PA +AG ++VV+ SP P A E L AA L GV + + +GGAQA+AALA+GTES
Sbjct: 136 STVLMTVVPARVAGVERVVVVSPNP-ARETLAAAYLLGVGEFYRIGGAQAVAALAYGTES 194

Query: 200 VPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQ 259
           V +V KI GPGN FVT AK+ V+      AIDM AGP+E  ++++ G    F+A+DL++Q
Sbjct: 195 VERVAKIVGPGNIFVTTAKKLVAFD---CAIDMLAGPTEAAIVSERG-NARFIAADLVAQ 250

Query: 260 AEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALN-ASRLIVTKDLAQCVE 318
           AEH P++ V   T +  +A  V + V    A   +   AR+AL     + V +D+AQ +E
Sbjct: 251 AEHDPETMVAFFTTSPSLADAVKKQVALLAA---KNTIARKALATRGYIFVAQDIAQAME 307

Query: 319 ISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATC 378
            +NQ+  EHL +      +L+++++SAGSVF+GD+S +S GDYASG NHVLPT G     
Sbjct: 308 AANQFASEHLTVD----EDLLETVSSAGSVFVGDYSAQSFGDYASGPNHVLPTGGLARVR 363

Query: 379 SSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
             L + D+ K +TVQ++S++G  ALA   ETLAAAE L AH  +V +R
Sbjct: 364 GGLSVLDYVKIITVQKISRKGLRALAPIAETLAAAEGLVAHGQSVAIR 411


>UniRef50_B5YE85 Histidinol dehydrogenase n=1 Tax=Dictyoglomus thermophilum H-6-12
           RepID=B5YE85_DICT6
          Length = 416

 Score =  449 bits (1156), Expect = e-125,   Method: Composition-based stats.
 Identities = 126/410 (30%), Positives = 214/410 (52%), Gaps = 18/410 (4%)

Query: 21  LMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA--LKVSAEEIAAASE 78
            +R   S  + I + V  I++ VK +GD AL ++S ++D         K++  +I     
Sbjct: 14  FLRIEDSKIKEIEKNVEFIIEEVKTKGDLALYDFSLRYDNYDSRKYGFKINVPDID---- 69

Query: 79  RLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPL 138
            LS +   A+ V ++ ++ ++  +       +    +   Q+  PV SV LY+PGG A  
Sbjct: 70  -LSTDFAVAIKVMIERVKNYYMHEYKNSWFYKDGESIF-GQLVVPVDSVLLYVPGGRASY 127

Query: 139 FSTVLMLATPASIAGCKKVVLCSPPPI--ADEILYAAQLCGVQDVFNVGGAQAIAALAFG 196
            STV+M   PA IAG K + + +PP       +LY  ++ G+++++ +GGA AI+A A+G
Sbjct: 128 PSTVVMGLVPAIIAGVKNLYVTTPPSKRDDKNLLYTLRILGIKELYLLGGAHAISAFAYG 187

Query: 197 TESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVI--ADSGATPDFVAS 254
           TES+PKVD I GPGN +V  AK++V   ++   ID   GPSEVLV    D       V  
Sbjct: 188 TESIPKVDMIIGPGNLYVALAKKKVFGDVN---IDGIFGPSEVLVWVNYDKDLNLRKVVC 244

Query: 255 DLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLA 314
           D L+Q EH P  +  ++  + ++   + E +++++ +  R +  +++L  S LI+ ++  
Sbjct: 245 DFLAQLEHSPYDRGWIIV-SENLVYDLLELIKKEVEDSERGDILKESLKNSFLIIEENEK 303

Query: 315 QCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGY 374
             + + NQ GPEHL I        +  I +AG++F+   S    GD+ +G +H+LPT G 
Sbjct: 304 NAINLINQIGPEHLEIIDPFGERYIPYIKNAGAIFINHSS--IFGDFIAGPSHILPTGGS 361

Query: 375 TATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVT 424
               S L +  F KR++  +LS +    LA    T+A  E    H+ ++ 
Sbjct: 362 AKFSSGLSVNSFLKRISFVKLSTQDQKILAKYGSTIAREEGFYMHEKSLR 411


>UniRef50_O33775 Histidinol dehydrogenase n=12 Tax=Sulfolobaceae RepID=HISX_SULSO
          Length = 398

 Score =  446 bits (1147), Expect = e-124,   Method: Composition-based stats.
 Identities = 139/403 (34%), Positives = 218/403 (54%), Gaps = 23/403 (5%)

Query: 30  ESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAMA 89
             +   V DI+++VK +GD AL E + K DK  +  +K   EE+   + +L  ++KQA+ 
Sbjct: 15  SRVIPVVKDIIESVKTKGDNALYELTEKLDKVKIDNIKAREEELKTQASKLDPKVKQAID 74

Query: 90  VAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPA 149
            A + ++ FH    +PP       G+    + R +  +G+Y+P G     ST+LM   PA
Sbjct: 75  TAYEQLKAFHEM-LVPPNIGGGYQGISFGVIWRSIEKIGIYVPSGKYSYPSTLLMAGIPA 133

Query: 150 SIAGCKKVVLCSPPP----IADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDK 205
            +A  K++ + SPP     +   + Y A   GV +V+ +GGAQAIAALAFGTESV KV K
Sbjct: 134 KVAKVKEIYVASPPTQEGTVNPALAYVAIKLGVNEVYKIGGAQAIAALAFGTESVKKVYK 193

Query: 206 IFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPD 265
           I GPGN +V  AK  VS  +    ID   GP+E+++IAD  A  ++VA D+ +QAEHGPD
Sbjct: 194 IVGPGNVYVQAAKYLVSSVV---GIDGIEGPTELVIIADETAKAEYVALDMKAQAEHGPD 250

Query: 266 SQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQCVEISNQYGP 325
           + ++LL+   ++ RRV E +             +       +I TK+L + +EI+N+  P
Sbjct: 251 TYIVLLSNDDELIRRVEEKI-------------KNDKKIYYIIKTKNLDEAIEIANKIAP 297

Query: 326 EHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLAD 385
           EHL +  ++A  L+D I +AG++ LG+ +P +  DY +G NH+LPT G+      + + D
Sbjct: 298 EHLSLYVKDAYTLMDKIVNAGAISLGN-TPPAIIDYVAGPNHILPTNGWAKIRGGITVYD 356

Query: 386 FQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVN 428
           F K      + ++    L     +LA  E    H  ++  R  
Sbjct: 357 FIKPTMYANV-RDINKQLLEASISLANYEGFIIHGKSIGARYE 398


>UniRef50_Q46N53 Histidinol dehydrogenase 2 n=50 Tax=root RepID=HISX2_RALEJ
          Length = 436

 Score =  443 bits (1139), Expect = e-123,   Method: Composition-based stats.
 Identities = 137/417 (32%), Positives = 214/417 (51%), Gaps = 13/417 (3%)

Query: 22  MRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLS 81
            +   + + +  + V ++L  ++ARG +A+R+Y+ + D  +   + ++ ++I   ++ + 
Sbjct: 9   EKTPQTETATAQKVVTEMLAEIQARGKDAVRQYAKQLDGWS-GDIVLTPDQIREQTKDVP 67

Query: 82  DELKQAMAVAVKNIETFHTAQK--LPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLF 139
             ++  +  A++ +  F  AQ+  L    VE  PGV   Q   PV  VG Y P G     
Sbjct: 68  AGVRADIDFAIRQVTDFALAQRESLKEFSVELHPGVTAGQRVLPVNVVGCYAPAGRYAHI 127

Query: 140 STVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQDVFNVGGAQAIAALAF 195
           ++  M    A  AG K VV CS P     I   +LYA Q  G   +  +GG QAIA++A+
Sbjct: 128 ASAYMGVATAKAAGVKTVVACSSPFRGQGIHPHVLYAFQAAGADVIMALGGVQAIASMAY 187

Query: 196 GTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASD 255
           G  +    D + GPGN FV EAKR +  ++    ID+ AGPSEV VIAD  A P  VASD
Sbjct: 188 GLFTGKPADVVVGPGNKFVAEAKRSLYGQV---GIDVFAGPSEVAVIADETADPAIVASD 244

Query: 256 LLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPR--AETARQAL-NASRLIVTKD 312
           L+ QAEHG +S   L T + D+A RV   V   +A+LP    + A  A  +   +I+   
Sbjct: 245 LVGQAEHGHESPAWLFTTSRDLADRVMALVPELIAKLPPTARDAATAAWRDYGEVILCGT 304

Query: 313 LAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTY 372
             + VEIS++Y  EHL + T +    + ++T  GS+FLG+ +  + GD  SG NHVLPT 
Sbjct: 305 REEVVEISDRYASEHLEVHTADLDWWLANLTCYGSLFLGEETTVAFGDKTSGPNHVLPTK 364

Query: 373 GYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNA 429
           G       L +  F K +T Q++++E    +      ++  E + AH      R+  
Sbjct: 365 GAARYSGGLSVHKFMKTLTWQQMTREATRQIGQVTARISRLEGMEAHARTADDRMAK 421


>UniRef50_C7LZ86 Histidinol dehydrogenase n=1 Tax=Acidimicrobium ferrooxidans DSM
           10331 RepID=C7LZ86_ACIFD
          Length = 432

 Score =  439 bits (1130), Expect = e-122,   Method: Composition-based stats.
 Identities = 157/434 (36%), Positives = 225/434 (51%), Gaps = 9/434 (2%)

Query: 1   MSFNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDK 60
           M+  T++D    T   +R  L   A+   E     V +I+ +V+  GD AL + + +FD 
Sbjct: 1   MASLTLVDLRETTGALRRDDLPGVALPV-EGPRALVREIVQSVRTGGDGALADLTERFDG 59

Query: 61  TTVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQV 120
               AL +  E +AAA ERL   L +A+ VA   +   + A++     +    G+  ++ 
Sbjct: 60  VRPRALVLGREAMAAAYERLDRRLAEALRVARDRVREAYEAERPAASSL-VADGIEVRRR 118

Query: 121 TRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLC 176
             PV   G Y+PGG A   S+V+  AT A +AG + VV+ +PP     + D  L A  L 
Sbjct: 119 IVPVERAGCYVPGGQARYPSSVVHTATVARVAGVRDVVVATPPLPDGGLDDATLAACHLA 178

Query: 177 GVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGP 236
           GV  V   GGAQA+AALA+GTES+ +VD I GPGN FV+ AK++V+  +        AGP
Sbjct: 179 GVDTVLLAGGAQAVAALAYGTESLERVDVIVGPGNLFVSLAKQEVAADVGVPG--AFAGP 236

Query: 237 SEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAE 296
           SEV+V+AD    P   A D+  QAEHGP     L+T  A  A +V E +   +   PR  
Sbjct: 237 SEVVVVADGSLEPRVAAIDVAVQAEHGPHGLAWLVTWDARWAEQVLEELAAYVEASPRRA 296

Query: 297 TARQALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSP 355
                L     L + +D  Q   +++   PEHL +    A    D +  AG VF+G  + 
Sbjct: 297 QLESTLEAHGYLALVRDRDQARLVADAIAPEHLELLYDQAVRDADRVRHAGVVFVGRAAS 356

Query: 356 ESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAER 415
            + GDY +G +HVLPT G     S LGL DFQ+R+ V E+  E  S L   +E LA AE 
Sbjct: 357 AAFGDYVAGPSHVLPTAGTARFASVLGLEDFQRRLHVVEVHDEALSRLGWAVEALADAEG 416

Query: 416 LTAHKNAVTLRVNA 429
           L AH +++ +R  A
Sbjct: 417 LVAHADSIRIRREA 430


>UniRef50_Q0AP81 Histidinol dehydrogenase, Histidinol-phosphatase n=10 Tax=Bacteria
           RepID=Q0AP81_MARMM
          Length = 631

 Score =  439 bits (1129), Expect = e-121,   Method: Composition-based stats.
 Identities = 188/431 (43%), Positives = 259/431 (60%), Gaps = 6/431 (1%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              I++W   + E + + L RPA S+S        DI+D ++ +GDEA+R Y+ + D   
Sbjct: 1   MLDILNWTDASPEARTRALTRPASSSSAGPAA--RDIVDAIRDQGDEAVRAYAKRLDGYA 58

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
               +V    + AA   L     +A+  A   +  FH  Q      VET PGV   +   
Sbjct: 59  PGDFRVPEGVLKAARAALDPRDAEAIKAAADAVRRFHVQQGYRGYSVETWPGVTASRRAT 118

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGV 178
           PV +  LY+P GSAPL S+++MLA PA +AG  ++V+ +PP     +   +L AA L G+
Sbjct: 119 PVDTAALYVPAGSAPLVSSLIMLAIPAQLAGVPRIVVVAPPAGDGGVNPALLAAADLLGL 178

Query: 179 QDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSE 238
            +V+ +GGAQAIAAL+FG   +P+ DKIFGPGNA+V  AK  VS    G A+D+PAGPSE
Sbjct: 179 DEVYAIGGAQAIAALSFGAAGLPRADKIFGPGNAYVAAAKAYVSSLPGGPAVDLPAGPSE 238

Query: 239 VLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETA 298
           V+VIAD  A PD VASDLLSQAEH P +QV+L+   A  A RV  +V + L +LPRA  A
Sbjct: 239 VMVIADETADPDLVASDLLSQAEHDPSAQVMLVCFDAATADRVTASVAKLLEDLPRAAIA 298

Query: 299 RQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESA 358
           R+AL AS ++V   +   ++I+N Y PEHLI+Q  +A  L+  +  AGS+F+G W+PE+A
Sbjct: 299 REALAASAILVCDSVDDAIDIANIYAPEHLILQAESAERLLAGVRHAGSIFVGAWTPEAA 358

Query: 359 GDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTA 418
           GDYA+G NH LPT G       + +  FQK  T+   S+ G  ALA T+E LAA E+L A
Sbjct: 359 GDYAAGPNHTLPTAGAARAHGGVSVESFQKTTTILRASEAGAVALAPTVERLAALEQLDA 418

Query: 419 HKNAVTLRVNA 429
           H  A+ LR   
Sbjct: 419 HGLAMRLRRER 429


>UniRef50_A0R401 Histidinol dehydrogenase n=2 Tax=Actinomycetales RepID=A0R401_MYCS2
          Length = 451

 Score =  434 bits (1117), Expect = e-120,   Method: Composition-based stats.
 Identities = 153/419 (36%), Positives = 229/419 (54%), Gaps = 12/419 (2%)

Query: 24  PAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDE 83
           P       +   V+ +L +++ RG +A+R Y+ + D  +   L++ A+E+  + + L  +
Sbjct: 25  PPAQRDPKVVERVSQMLLDIERRGLDAVRAYARELDGWS-GPLEIGADELRKSGDALPAD 83

Query: 84  LKQAMAVAVKNIETFHTAQK--LPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFST 141
           L++A+ +  +    F  AQ+  L   ++E  PGV       PV  VG Y+P G  PL ++
Sbjct: 84  LREALELGYERTNRFAVAQRARLTDFEIELAPGVTGGVQYVPVNRVGAYLPAGRFPLLAS 143

Query: 142 VLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQDVFNVGGAQAIAALAFGT 197
             M    A  AG   V+ C+PP         +LY A L     VF VGG QA+ A+AFG 
Sbjct: 144 AFMTVGVAKAAGVPTVLACTPPSGEHGAHPAVLYGAYLSRADSVFAVGGVQALGAMAFGL 203

Query: 198 ESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLL 257
                VD + G GNAFVTEAKRQ+  R+    ID+ AGPSEV V+AD  A P++VA+DLL
Sbjct: 204 IGDGPVDMLVGAGNAFVTEAKRQLFGRV---GIDLLAGPSEVAVLADETADPEWVAADLL 260

Query: 258 SQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQC 316
            QAEHGP+S   L+T +  + RRV EA++RQL  L   E A  A  +   ++V  D  Q 
Sbjct: 261 GQAEHGPNSPAALITTSETLGRRVIEAIDRQLETLATREVAGPAWRDFGSVLVASDAEQA 320

Query: 317 VEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDY-ASGTNHVLPTYGYT 375
             I++  GPEHL +QT +    +  + + GS+FLG WS  +  D   +GTNHVLPT    
Sbjct: 321 AAIADVLGPEHLEVQTADDDYFLKRLRNYGSLFLGRWSTVAYSDKGIAGTNHVLPTGKTA 380

Query: 376 ATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNALKEQA 434
              + L ++ F K +T Q  ++E  +ALA  +E ++A E L AH+   T+R+  +   +
Sbjct: 381 RYNAGLSVSRFVKPLTYQRAAREATAALAPAVERISAFEGLAAHEATATIRIEEIGRDS 439


>UniRef50_A9G5W4 HisD protein n=1 Tax=Sorangium cellulosum 'So ce 56'
           RepID=A9G5W4_SORC5
          Length = 460

 Score =  431 bits (1110), Expect = e-119,   Method: Composition-based stats.
 Identities = 161/432 (37%), Positives = 222/432 (51%), Gaps = 28/432 (6%)

Query: 20  LLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTAL-KVSAEEIA---- 74
            L         ++T  V +I+DNV+  G  A+  Y  KF++ T  AL + +  E      
Sbjct: 18  ALRTRGTGDLANVTPAVTEIIDNVRRGGTSAVLGYIEKFERRTSKALVRHAGPEAEGGFG 77

Query: 75  --AASERLSDELKQAMAVAVKNIETFHTAQK----------------LPPVDVETQPGVR 116
              A  RLS E++ A+  A   I  +H  Q+                L       + GV 
Sbjct: 78  GAEALARLSPEVRAALETAAARIARYHERQRDAGDLGPANVTANGPALQAGFSYEEEGVL 137

Query: 117 CQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLC 176
                RP+  VG+Y PGG A   S+VLM A PA IAG +++VL SP    D  L AA L 
Sbjct: 138 LGMRVRPLRRVGVYAPGGKARYPSSVLMSAIPARIAGVREIVLASP-SADDATLAAAHLS 196

Query: 177 GVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGP 236
           GV  + + GGAQAIAA+A+G   +  VDKI GPGNA+V  AK+ V   +   +ID   GP
Sbjct: 197 GVTTLLDSGGAQAIAAMAYGLPELAPVDKIVGPGNAYVACAKKLVFGDV---SIDGITGP 253

Query: 237 SEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAE 296
           SE+L +AD  A P  VA+DLLSQAEH   S  +L T +A +A  VA  ++  L EL R  
Sbjct: 254 SEILALADESADPRLVAADLLSQAEHDEASYALLATTSAKLAEAVARELDAALPELTRRA 313

Query: 297 TARQALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSP 355
             + +L+  +  +V    A+  EI++Q   EH+     +A  L   I + G+  LGD +P
Sbjct: 314 IVQASLSTHAAALVVGSRARLAEIADQLAVEHVAFHVADAEGLFSEIGTLGAALLGDLTP 373

Query: 356 ESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAER 415
            +AGDY +G +HVLPT G     + LG+ DF  R ++   S     A    IE LA AE 
Sbjct: 374 VAAGDYLAGPSHVLPTGGSARFGAPLGVYDFVTRASLIRYSSAALRAQGPIIEKLALAEG 433

Query: 416 LTAHKNAVTLRV 427
           L AH  AV+LR+
Sbjct: 434 LQAHARAVSLRL 445


>UniRef50_C7RAI8 Histidinol dehydrogenase n=1 Tax=Kangiella koreensis DSM 16069
           RepID=C7RAI8_KANKD
          Length = 405

 Score =  429 bits (1105), Expect = e-119,   Method: Composition-based stats.
 Identities = 134/409 (32%), Positives = 214/409 (52%), Gaps = 22/409 (5%)

Query: 22  MRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLS 81
            RP ++ S  + + V  +L  ++  GD A+   S +FD      +++           L 
Sbjct: 14  KRPNLTQSPELFQQVAKLLKEIETGGDLAIDNLSKRFDGFQPRKIELRPYRDYE----LE 69

Query: 82  DELKQAMAVAVKNIETFHTAQK--LPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLF 139
            +L  ++  A + IE F   QK  L P  +E   GV   Q   P+ ++G YIPGG  PL 
Sbjct: 70  PQLLNSIEQAAQRIEAFCQLQKGSLQPQQIEEASGVFGFQ-YSPIEAIGAYIPGGRFPLI 128

Query: 140 STVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTES 199
           ST LM   PA +AGC++ V CSP  +   IL AA L G  + + +GGAQA+AA+A+G ++
Sbjct: 129 STALMTLIPARVAGCQRRVACSP-SVHPAILAAASLAGATEFWQIGGAQAVAAMAYGYQT 187

Query: 200 VPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQ 259
           +  V  + GPGN +V  AK+ +  R+    ID+ AGPSE+L++ADS A  +++ +D+ +Q
Sbjct: 188 MLPVQMVVGPGNQYVNVAKQLLQSRIK---IDVAAGPSELLILADSNANQEWLIADMAAQ 244

Query: 260 AEHGPDSQVILLTPAADMARRVAEAV--ERQLAELPRAETARQALNASRLIVTKDLAQCV 317
           AEH P +Q +L++      + + + +    +L  L + E          L+   D    +
Sbjct: 245 AEHDPQAQSVLVSDDIAFLQSIGQQLTANDELNNLLKGEQI-------VLLQANDCEAMI 297

Query: 318 EISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTAT 377
             SN+Y PEHL++   + R    S+   GS+F+G  S  + GDY +G NH LPT G    
Sbjct: 298 RFSNRYAPEHLLL--ADERIASQSLKHYGSLFIGQNSAVAFGDYCAGPNHTLPTMGSANR 355

Query: 378 CSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
            S L +  F    + Q+++ +G   LA     LA AE+L  H+ ++ +R
Sbjct: 356 SSGLCVQSFMNIQSYQQINDQGRIQLAEIGRPLAEAEQLVWHERSMQVR 404


>UniRef50_C1A4M1 Histidinol dehydrogenase n=1 Tax=Gemmatimonas aurantiaca T-27
           RepID=C1A4M1_GEMAT
          Length = 816

 Score =  422 bits (1086), Expect = e-116,   Method: Composition-based stats.
 Identities = 154/428 (35%), Positives = 238/428 (55%), Gaps = 15/428 (3%)

Query: 8   DWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALK 67
            W+      +R L  R A +   +I    + ++D V+  GD AL + + +FD  T+  L+
Sbjct: 12  SWDRLDNATRRALEDR-ASTVDPTIRERTSAVIDAVRRTGDAALIDMARRFDGATLETLE 70

Query: 68  VSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASV 127
           V   E   A   L   L+Q++  A +NI T H A          +PG+   +   P+  V
Sbjct: 71  VPRAEWDRALAALDPALRQSLERAARNIATVHRAFLPTITRSTPEPGITVVRRPDPLGRV 130

Query: 128 GLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIAD----EILYAAQLCGVQDVFN 183
           G+Y PGG A   S++LM A PA +AG  ++++C+PP         +L AA L  V  VF 
Sbjct: 131 GIYAPGGRAAYPSSLLMGAVPARVAGVGEIIVCTPPGPDGRPADVVLAAAALANVDRVFA 190

Query: 184 VGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIA 243
           VGGA AIAA+A GT SVP+VD+I GPGNA+V EAK Q+   +   AID PAGPSE+LV+A
Sbjct: 191 VGGAGAIAAMALGTASVPRVDRIMGPGNAYVAEAKLQL---VSAVAIDAPAGPSELLVLA 247

Query: 244 DSGATPDFVASDLLSQAEHGPDSQVILL----TPAADMARRVAEAVERQLAELPRAETAR 299
           D+ A  + +A ++L+QAEH PD+ V+ +    +  + +A RV  A++ QLA  PRA+  R
Sbjct: 248 DASADANTIAREMLAQAEHDPDAAVLAVIVDHSATSSLATRVETALQTQLASAPRADVMR 307

Query: 300 QALNA-SRLIVTKDLAQCVEISNQYGPEHLIIQTRNA--RELVDSITSAGSVFLGDWSPE 356
            AL A   ++    + + +  +N++  EHL++   +     ++ ++ +AG++F+G  S  
Sbjct: 308 AALGARGGVVHMTSMDEAITFANRWAAEHLLLLVDDTQRDRVLAALRNAGTIFVGASSSV 367

Query: 357 SAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERL 416
           + GDY +G NHVLPT G   + S L   DF +  T QE++    ++L++ +   A AE L
Sbjct: 368 AFGDYMTGANHVLPTAGAARSYSGLSTLDFVRWTTWQEVTPAAAASLSADVGRFADAEGL 427

Query: 417 TAHKNAVT 424
            AH     
Sbjct: 428 PAHAATAR 435


>UniRef50_B1ZNB2 Histidinol dehydrogenase n=3 Tax=Verrucomicrobia RepID=B1ZNB2_OPITP
          Length = 431

 Score =  422 bits (1086), Expect = e-116,   Method: Composition-based stats.
 Identities = 152/431 (35%), Positives = 233/431 (54%), Gaps = 14/431 (3%)

Query: 6   IIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVT- 64
           I+   S T +       R  +     IT +V  IL +V+ RGDEA+  Y+AKFD   +  
Sbjct: 3   ILHHASKTFDADVADFCRTTM-VPREITESVAAILADVRERGDEAVVYYAAKFDGAKLRA 61

Query: 65  -ALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRP 123
             L+V   ++  A++RL    ++A+  A  +I  ++          +   G    +   P
Sbjct: 62  RDLRVKPSDLTVAAKRLPAAERRALVAARDSIMDYNRRGLPRGWTAKNPHGAMVGEKFDP 121

Query: 124 VASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSP----PPIADEILYAAQLCGVQ 179
           +  VGLY+PGG  PL STVLM  T A IA C +VV+ +P      IAD +L A  L GV 
Sbjct: 122 LRRVGLYVPGGQVPLVSTVLMTVTLAKIAQCPQVVVFTPCNAEGKIADGLLAALHLLGVD 181

Query: 180 DVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEV 239
           +V+ VGG QAI A+AFGT ++P VDKIFGPGNA+  EA RQV   +    ++   GPSE+
Sbjct: 182 EVYRVGGVQAIGAMAFGTTTIPPVDKIFGPGNAYTCEAMRQVFGIV---GVNGLPGPSEL 238

Query: 240 LVIADSGATPDFVASDLLSQAEHGPDS-QVILLTPAADMARRVAEAVERQLAELPRAETA 298
           +VIAD  A  D+ A+DLL+QAEHG    +V L+  ++ +   +   +  QL  L R+E  
Sbjct: 239 MVIADDTARADYAAADLLAQAEHGSGREKVYLVATSSRVITEIVNEMNGQLQTLTRSEKT 298

Query: 299 RQALNASRL-IVTKDLAQCVEISNQYGPEHLIIQTRNA--RELVDSITSAGSVFLGDWSP 355
           ++ L    L I    + Q   ++N   PEHL +    A  ++L  ++T+AG++ +G+ +P
Sbjct: 299 QRVLEQGFLAIEVGSMQQAAAVANYVAPEHLELLVSEAAVKQLTKAVTTAGAIMIGNETP 358

Query: 356 ESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAER 415
            + GD+ +G +HVLPT       S + ++DF +R ++    ++     A  +   AA ER
Sbjct: 359 TALGDFTAGPSHVLPTGRAGRFFSGMRVSDFLRRTSLVRYDRKSVRKGAPVVAAFAAMER 418

Query: 416 LTAHKNAVTLR 426
           L AH  +V +R
Sbjct: 419 LDAHGRSVKIR 429


>UniRef50_C9SQK1 Histidine biosynthesis trifunctional protein n=1 Tax=Verticillium
           albo-atrum VaMs.102 RepID=C9SQK1_VERA1
          Length = 699

 Score =  411 bits (1056), Expect = e-113,   Method: Composition-based stats.
 Identities = 159/434 (36%), Positives = 222/434 (51%), Gaps = 79/434 (18%)

Query: 7   IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTAL 66
            D +  +A +  ++L RP+  + E+I   V  I+D V++ GD+A+  Y+ KF+K T    
Sbjct: 338 YDASKVSAAEVTEVLKRPSQKSPEAILNIVKPIIDEVRSGGDKAVLSYTHKFEKATSLTS 397

Query: 67  KVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKL-PPVDVETQPGVRCQQVTRPVA 125
            V        + +LS E  +A+ ++ +NI  FH AQK   P+ VET PGV C +++RP+ 
Sbjct: 398 PVLRAPFPEEAMKLSKESIKAIDISFENIRKFHAAQKEDKPLHVETMPGVVCSRMSRPIE 457

Query: 126 SVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIA----DEILYAAQLCGVQDV 181
            VGLYIPGG+A L ST LML  PA +AGCKK+V  SPP        EI+Y A   G + +
Sbjct: 458 RVGLYIPGGTAVLPSTALMLGVPAMVAGCKKIVFASPPRADGSLTPEIVYVAHKVGAESI 517

Query: 182 FNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLD-GAAIDMPAGPSEVL 240
              GGAQA+AALA+GTESVPKVDKI GPGN FVT AK  VS   + G +IDMPAGPSEV 
Sbjct: 518 VLAGGAQAVAALAYGTESVPKVDKILGPGNQFVTAAKMFVSNDTNAGVSIDMPAGPSEVR 577

Query: 241 VIADS-GATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETAR 299
            I ++   + D+    L+ Q ++ P                               E A+
Sbjct: 578 DIDEAMRISNDYAPEHLILQLKNAP-------------------------------EVAQ 606

Query: 300 QALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAG 359
             +NA  + +                                         G+W+PES G
Sbjct: 607 MVMNAGSIFI-----------------------------------------GEWTPESVG 625

Query: 360 DYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAH 419
           DY++G NH LPTYG+    S + L  F K +T   L+ EG   + S +  LA  E L AH
Sbjct: 626 DYSAGVNHSLPTYGFAKQYSGVNLGSFVKHITSSNLTAEGLRNVGSAVMQLAKVEELEAH 685

Query: 420 KNAVTLRVNALKEQ 433
           + AV +R+N L ++
Sbjct: 686 RRAVEIRLNYLDKK 699


>UniRef50_B5YLM0 Histidinol dehydrogenase n=1 Tax=Thalassiosira pseudonana CCMP1335
           RepID=B5YLM0_THAPS
          Length = 441

 Score =  407 bits (1048), Expect = e-112,   Method: Composition-based stats.
 Identities = 140/396 (35%), Positives = 204/396 (51%), Gaps = 22/396 (5%)

Query: 49  EALREYSAKFDKTTV--TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPP 106
           +AL   + +        ++  VS+ +   A + LSDE ++++      ++ F  AQ+   
Sbjct: 48  KALISIARRLSDILPASSSYTVSSAQCKEAFDSLSDEDRRSLLNIHARVKLFADAQRGSV 107

Query: 107 VDVETQ-PGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPI 165
           VDVE   PG +      P  + G Y PGG  PL S+VLM    A  AGC  VVL SP P 
Sbjct: 108 VDVEVDIPGGKAGHTVSPCRAAGCYAPGGRYPLPSSVLMTVVTARSAGCPYVVLASPRP- 166

Query: 166 ADEILYAAQLCGVQDVFNVGGAQAIAALAFGTE------------SVPKVDKIFGPGNAF 213
           A   L AA + G   V  VGGAQAI  +A+G +            ++P  D I GPGN +
Sbjct: 167 APITLAAAHVAGADVVLCVGGAQAIGCMAYGVDEYDGEDGGTKVDAIPACDVIVGPGNKW 226

Query: 214 VTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTP 273
           VT AK  V+       IDM AGPSEVLVI D  A  + VA+DL++QAEH   ++ IL++ 
Sbjct: 227 VTAAKSIVNGH---CGIDMLAGPSEVLVICDHTANAEIVAADLIAQAEHDVVARAILVSD 283

Query: 274 AADMARRVAEAVERQLAELP--RAETARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQ 331
              +  +V + VE+Q+  LP     TA++AL  S  I+ KD+ +C+ +S++  PEHL IQ
Sbjct: 284 DKTVIDKVDQEVEKQVECLPEPNRSTAKEALKQSFSILCKDIDECIAMSDKLAPEHLEIQ 343

Query: 332 TRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMT 391
           T N++ +    ++ G +F+G  + E  GDY +G NH LPT G       L + +F +  T
Sbjct: 344 TLNSQSVGMKCSNYGGLFIGTHAAEVLGDYGAGPNHTLPTGGTGRYTGGLSVFNFLRIRT 403

Query: 392 VQELSKEG-FSALASTIETLAAAERLTAHKNAVTLR 426
              + +EG    +      +A  E L  H  A   R
Sbjct: 404 WMRIDEEGKSQEMVEDSVRMARLEGLEGHARAAEKR 439


>UniRef50_UPI0001C3165E histidinol dehydrogenase n=1 Tax=Conexibacter woesei DSM 14684
           RepID=UPI0001C3165E
          Length = 426

 Score =  394 bits (1012), Expect = e-108,   Method: Composition-based stats.
 Identities = 146/414 (35%), Positives = 208/414 (50%), Gaps = 18/414 (4%)

Query: 22  MRPAISASESITRTVNDILDNVKARGDEALREYSAKFD--KTTVTALKVSAEEIAAASER 79
           +R  + A+ SI   V  I+ +V+ RGD A+ E +   D       AL+VS  E+ AA + 
Sbjct: 21  LRRLVPAAASIADPVAAIVADVRDRGDAAVLELTRAHDTGGAEPKALRVSQSELDAALDS 80

Query: 80  LSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLF 139
           L  +++  + VA +N+            +V    G   +    PV    +Y+PGG AP  
Sbjct: 81  LDADVRAGLEVAAQNVGVVAAIGLDDEREVTLGHGQTVRLREVPVRRAAVYVPGGRAPYP 140

Query: 140 STVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQDVFNVGGAQAIAALAF 195
           STVLM    A  AG ++VVLCSPP     +   IL AA L G  +V+ +GGAQAI ALA 
Sbjct: 141 STVLMGVVTAVTAGVEEVVLCSPPGPDGDLNPAILAAAALAGATEVYRMGGAQAIGALAH 200

Query: 196 GTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASD 255
           GT +V  VD I GPGN +V EAKRQVS       ID  AGPS+++V+ D GA     A D
Sbjct: 201 GTATVAPVDLIVGPGNLWVQEAKRQVSAA-GLVGIDGFAGPSDLMVVLDRGADVRLAALD 259

Query: 256 LLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQ 315
           L +QAEHG DS V+ ++P         +A+   L+ +P             L+ T  L  
Sbjct: 260 LRAQAEHGSDSLVLAVSPDG----AALDALSEGLSVVPEPGV-------GALVETASLED 308

Query: 316 CVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYT 375
            + ++N + PEHL +    A  L   + +AG +F+G     + GDY +G+NH LPT G  
Sbjct: 309 ALALANAFAPEHLELIGAGAEALAPEVRNAGCLFVGPGGATAFGDYVAGSNHTLPTDGAA 368

Query: 376 ATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNA 429
              S L    F++RMT   +  E  + LA     +A AE    H  ++  R+  
Sbjct: 369 RFASGLSARHFRRRMTEVRIPLEAATTLAPAGAAIARAEGFELHAQSMEARMRE 422


>UniRef50_B7FPZ7 Histidinol dehydrogenase (Fragment) n=3 Tax=Eukaryota
           RepID=B7FPZ7_PHATR
          Length = 347

 Score =  379 bits (974), Expect = e-103,   Method: Composition-based stats.
 Identities = 135/338 (39%), Positives = 183/338 (54%), Gaps = 10/338 (2%)

Query: 95  IETFHTAQKLPPVDVE-TQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAG 153
           +  F T Q+   VD E   PG +  Q  RP  + G Y PGG  PL S+V+M A  A  AG
Sbjct: 1   VLAFATMQRSSVVDKEMDIPGGKAGQTVRPCGAAGCYAPGGRYPLPSSVIMTAVTARAAG 60

Query: 154 CKKVVLCSPPPIADEILYAAQLCGVQDVFNVGGAQAIAALAFGT--ESVPKVDKIFGPGN 211
           C+ VVL SP P A   L AA L G      VGGAQAIA++A+G     VP+ D I GPGN
Sbjct: 61  CETVVLSSPKP-APITLAAAYLSGADHFLCVGGAQAIASMAYGIVDSDVPRCDVICGPGN 119

Query: 212 AFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILL 271
            +VT AK  V+       IDM AGPSEVLVI D  A P+ VA+DL++QAEH   ++ ILL
Sbjct: 120 KWVTAAKSIVNGH---CGIDMLAGPSEVLVICDDTANPEIVAADLIAQAEHDVVARAILL 176

Query: 272 TPAADMARRVAEAVERQLAELP--RAETARQALNASRLIVTKDLAQCVEISNQYGPEHLI 329
           + +  +  +V E V +Q+  LP     TA +AL  S  +  + L QC+ IS+   PEHL 
Sbjct: 177 STSDAIIEQVDENVSKQIEALPEPNRSTALEALKQSFAVKCESLEQCIAISDDIAPEHLE 236

Query: 330 IQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKR 389
           IQTR+A ++ ++  + G +F+G+ + E  GDY +G NH LPT G       L + +F + 
Sbjct: 237 IQTRDAMKVGEACNNYGGLFIGEHAAEVLGDYGAGPNHTLPTGGTGRYTGGLSVFNFLRV 296

Query: 390 MTVQELS-KEGFSALASTIETLAAAERLTAHKNAVTLR 426
            T   +        + +    +A  E L  H  A   R
Sbjct: 297 RTWMRVDNAAASQTMVNDSIIMARLEGLEGHARAAETR 334


>UniRef50_A8M914 Histidinol dehydrogenase n=1 Tax=Caldivirga maquilingensis IC-167
           RepID=A8M914_CALMQ
          Length = 399

 Score =  374 bits (961), Expect = e-102,   Method: Composition-based stats.
 Identities = 131/414 (31%), Positives = 209/414 (50%), Gaps = 31/414 (7%)

Query: 21  LMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERL 80
           L+R A    + +   V  I+++VK  GDEAL   +++ D   ++++++S  E+ A +  +
Sbjct: 11  LLRKATDMDQYV-DRVRGIINDVKEHGDEALLRLTSELDGVKLSSIELSQSELRALASGI 69

Query: 81  SDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFS 140
              +++A+   + ++E+F+T  K    +   + G+R      P++ VGLY+P G    FS
Sbjct: 70  EPRVREALDEVMASVESFNTGVKPRDFEDYHR-GLRRGVKWVPLSRVGLYVPKG---YFS 125

Query: 141 TVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQDVFNVGGAQAIAALAFG 196
           T++M    A +AG ++++  +PP     I  EI Y A       VF VGGAQA+AALAFG
Sbjct: 126 TLVMTGVLAKVAGVEEIIAVTPPRRDGLIDPEIAYVALRLNA-RVFRVGGAQAVAALAFG 184

Query: 197 TESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDL 256
           TESVP+VDKI GPGNA+V  AK  VS  +    ID   GP+E++  AD G  P  VA DL
Sbjct: 185 TESVPRVDKIIGPGNAYVQAAKLLVSSHV---GIDGVEGPTELVTCADPGIKPITVALDL 241

Query: 257 LSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQC 316
            +Q EH   +  +++T +      + + + + L   P               +  + ++C
Sbjct: 242 AAQLEHA-GAVGVVVTWSEGYLTAIEDELSK-LTNAP-----------YFSTLVNEPSEC 288

Query: 317 VEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTA 376
           V + N+  PEH  I     +  ++ I +AG+V +   +P +  DYA+G +HVLPT G   
Sbjct: 289 VNVINEVAPEHASIW--GVKIPIEGIRNAGAVSI--MAPSALVDYAAGPSHVLPTGGSAR 344

Query: 377 TCSSLGLADFQKRMTVQE-LSKEGFSALASTIETLAAAERLTAHKNAVTLRVNA 429
               L   DF K +   E  S +    L      L   E    H  A+T  +N 
Sbjct: 345 WRGVLTPMDFMKPIAYVEPTSGDEARRLGELGAVLGLREGFRRHSEALTNWINE 398


>UniRef50_C6UN35 Histidinal/histidinol dehydrogenase n=1 Tax=Candidatus Hodgkinia
           cicadicola Dsem RepID=C6UN35_HODCD
          Length = 428

 Score =  364 bits (936), Expect = 3e-99,   Method: Composition-based stats.
 Identities = 137/408 (33%), Positives = 196/408 (48%), Gaps = 11/408 (2%)

Query: 25  AISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDEL 84
               S  +      I   V A  D+AL  Y+ + D      L+ +  +I    E +  + 
Sbjct: 23  RARVSARVKAVAEKISQTVSAYADKALMAYNLRLDGCASRLLRFAP-DID--LETVDVKA 79

Query: 85  KQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLM 144
             ++ +A+  +   H+ Q      V    G +      PV+SVG+Y+PGG+A   S+V+M
Sbjct: 80  LFSLKLALDRVAALHSLQLPSSCCVRDALGAKLGFRWTPVSSVGVYVPGGTASYLSSVIM 139

Query: 145 LATPASIAGCKKVVLCSPPPI---ADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVP 201
              PA IAG   + L +P          +  A+LCGV  V+  GGA A+AAL+ GT +V 
Sbjct: 140 CCVPARIAGVGHISLATPYSKLANKPLFMACAKLCGVACVYPFGGAHAVAALSVGTRAVR 199

Query: 202 KVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAE 261
           KVDKI GPGNAFV  AK     R+    +D  AGPSE +++AD  A    +A D L Q E
Sbjct: 200 KVDKIVGPGNAFVAAAKALAQGRV---GVDCLAGPSEAVIVADGVADAWTLAVDSLCQLE 256

Query: 262 HGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRL-IVTKDLAQCVEIS 320
           H  D+   ++  +A++A RV   V   +    R  TA ++ +A  + +V   +A      
Sbjct: 257 HASDALTAVVVSSAELASRVRANVALLVRSARRRRTAERSWSAGGVSVVCCCVADAAATV 316

Query: 321 NQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSS 380
           N    EH+        +L+  +TSAG+VFLG  SP   GDY  GTNH LPT       S 
Sbjct: 317 NALASEHVQACVLKPAKLLTKLTSAGAVFLGGGSPIVVGDYVGGTNHTLPTASGAKFASG 376

Query: 381 LGLADFQKRMTVQEL-SKEGFSALASTIETLAAAERLTAHKNAVTLRV 427
           L + DF KR  V  L +     ALA      A+AE L+ H  A   R+
Sbjct: 377 LSVLDFMKRTYVTWLPTARPMLALAPACAACASAEGLSCHALASASRL 424


>UniRef50_A8A9G5 Histidinol dehydrogenase n=1 Tax=Ignicoccus hospitalis KIN4/I
           RepID=A8A9G5_IGNH4
          Length = 404

 Score =  347 bits (892), Expect = 4e-94,   Method: Composition-based stats.
 Identities = 129/410 (31%), Positives = 197/410 (48%), Gaps = 34/410 (8%)

Query: 23  RPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSD 82
           R ++   E + + V  ++  VKARG EA+++Y+  FD      + +S E+ A+ S+   +
Sbjct: 26  RGSLDLWEYVEK-VMPVVKEVKARGLEAVKKYNKAFDNYE-GCVSLSQEDFASYSK---E 80

Query: 83  ELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTV 142
            L       ++ +  FH  Q  P     +  GVR   + RPV  +G Y+PGG  P  ST 
Sbjct: 81  SLVSLFEEVLEQLSAFHK-QTAPKDSAFSSKGVRAVTLWRPVERLGAYVPGGLYPYPSTA 139

Query: 143 LMLATPASIAGCKKVVLCSPPPIA-DEILYAAQLC-GVQDVFNVGGAQAIAALAFGTESV 200
           LM A  A   G K+V + +PP  A  E++ +A L   V  V   GGA  ++ALA+    V
Sbjct: 140 LMTAGVAKALGVKEVTVATPPKFATSEVMASAFLASKVDSVLAAGGAHGVSALAY----V 195

Query: 201 PKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQA 260
               K+ GPG  +V  AK  VS  +    IDM AGP+E+ VIADS A P+ VA D+L+QA
Sbjct: 196 AGAHKVVGPGGPYVQAAKLLVSVDVP---IDMIAGPTELAVIADSSADPEEVAYDMLAQA 252

Query: 261 EHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQCVEIS 320
           EHGP S  +L++    +   V + V+             +        V +DL +   + 
Sbjct: 253 EHGPTSFALLVSTDEGLVLEVEKRVK-----------GEEVEGGLYATVVRDLEEAKRLV 301

Query: 321 NQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSS 380
           ++  PEH+ +        V     AG+      +P    DY++G NHVLPT G+      
Sbjct: 302 SELAPEHVSVYAETYEPPV-----AGAASF--KAPSPFLDYSAGPNHVLPTSGWAKARGP 354

Query: 381 LGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNAL 430
           LG  DF +  T+ E+  E    L    E LA  E +  H  A+  +++ +
Sbjct: 355 LGPVDFMRWTTLVEVFPEAADLLKLAAE-LARLEGMKYHAKAIEYKLSKI 403


>UniRef50_B9NIZ3 Histidinol dehydrogenase n=1 Tax=Populus trichocarpa
           RepID=B9NIZ3_POPTR
          Length = 394

 Score =  329 bits (845), Expect = 9e-89,   Method: Composition-based stats.
 Identities = 111/257 (43%), Positives = 154/257 (59%), Gaps = 12/257 (4%)

Query: 25  AISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVT---ALKVSAEEIAAASERLS 81
           +     +I + V DIL +V+ RGD A+ EY+A+FD   V    AL+++  E+ AA + L 
Sbjct: 132 SADTDAAIEQRVADILADVQKRGDAAVLEYTARFDGLQVEGMAALELTQAELKAAFDSLG 191

Query: 82  DELKQAMAVAVKNIETFHTAQKL---PPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPL 138
           DE + A+  A + + T+H AQK             G    Q   P+  VG+Y+PGG A  
Sbjct: 192 DEQRDALTAAAQRVRTYHEAQKRASGESWSYRDADGTLLGQKVTPLDRVGIYVPGGKAAY 251

Query: 139 FSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCGVQDVFNVGGAQAIAALAF 195
            S+VLM A PA +AG +++++  P P       +L AA + GV   F +GGAQA+AALA+
Sbjct: 252 PSSVLMNAIPAHVAGVQEIIMVVPTPRGEKNALVLAAAYVAGVTRGFTIGGAQAVAALAY 311

Query: 196 GTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASD 255
           GT ++PKVDKI GPGNA+V  AK++V   +    IDM AGPSE+LV+AD    PD+VA D
Sbjct: 312 GTATIPKVDKITGPGNAYVASAKKRVFGTV---GIDMIAGPSEILVLADGSTPPDWVAMD 368

Query: 256 LLSQAEHGPDSQVILLT 272
           L SQAEH   +Q ILL 
Sbjct: 369 LFSQAEHDELAQSILLC 385


>UniRef50_P72946 Putative histidinol dehydrogenase 2 n=1 Tax=Synechocystis sp. PCC
           6803 RepID=HISX2_SYNY3
          Length = 409

 Score =  298 bits (765), Expect = 2e-79,   Method: Composition-based stats.
 Identities = 99/382 (25%), Positives = 164/382 (42%), Gaps = 20/382 (5%)

Query: 15  EQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIA 74
           ++ R+L  RP  S    + + V             A  E+ A  D       +VS  E+ 
Sbjct: 13  QELRRLHHRPVPSPWPVMAQVV-------------AAMEHWAAMD--QDAPPRVSGAELD 57

Query: 75  AASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGG 134
           AA +R+S E    +  A   +E  +  Q         + G    Q   PV   G Y+   
Sbjct: 58  AAYQRISQEKLSVIRQACAALEQVYRPQLPKTQVSFPEDGTVRGQRFYPVRRAGFYLEAK 117

Query: 135 SAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVFNVGGAQAIAALA 194
                  +L     A   G  + VL +   I+  IL AAQ  G+++++   G  AIA L 
Sbjct: 118 RGDALGNLLRQGMLAKTVGVAERVLVTE-TISSTILVAAQEMGIEEIYLAAGVPAIAMLT 176

Query: 195 FGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVAS 254
           +G +++  V+ I G G   V  AK+ VS  +    ID     + ++V+AD  A   ++A 
Sbjct: 177 WGAKNIAPVESITGAGCPRVMAAKQLVSGVV---TIDQTLARTNLMVLADGEANGQWLAL 233

Query: 255 DLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLI-VTKDL 313
           DLL+ AE  P++  +LLT   ++   V ++V R   E   +    +AL    L+ + +DL
Sbjct: 234 DLLAHAEQYPNASAVLLTDRLELGEEVIQSVNRYCREQEHSVHTEKALAHYGLVAIVEDL 293

Query: 314 AQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYG 373
             C    N++ P  L++   +   +V+ +  A  +++G  SP   G Y SG N +    G
Sbjct: 294 EACGSWINEFCPHILLLAMEDPWTMVEKVQRAREIYIGHRSPSILGHYLSGANRLQTQDG 353

Query: 374 YTATCSSLGLADFQKRMTVQEL 395
             AT S L    F +   + + 
Sbjct: 354 AMATASELAFHCFLRSSQLLDY 375


>UniRef50_Q8ZY17 Histidinol dehydrogenase n=5 Tax=Thermoproteaceae RepID=HISX_PYRAE
          Length = 368

 Score =  297 bits (760), Expect = 8e-79,   Method: Composition-based stats.
 Identities = 108/398 (27%), Positives = 178/398 (44%), Gaps = 34/398 (8%)

Query: 28  ASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQA 87
               +  +V  I+D+V++ G +A  EYS + D        V+         +  D    +
Sbjct: 4   FPREVLESVWKIVDDVQSGGLKAALEYSKRLDGVAPEPHLVTP-------RQGGDPEVVS 56

Query: 88  MAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLAT 147
            A+A         ++  PP  V+   G+  Q + +PV    LY+P   A   ST++MLA 
Sbjct: 57  AALAAAKSLEALYSRISPPAAVDFYGGILRQILWKPVRRAALYVP---ARYISTLVMLAV 113

Query: 148 PASIAGCKKVVLCSPP-PIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKI 206
           PA +AG ++V + +PP  +++E+L  A+  GV+ V  +GG   +A   F       VD +
Sbjct: 114 PARLAGVEEVYVVTPPRGVSEELLAVAKELGVKAVLALGGPHGLAYAVFHM----GVDVV 169

Query: 207 FGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDS 266
            GPG  +V  AK  +SQ +    ID   GP+E+++ A  G  P+      L+Q EHGP S
Sbjct: 170 AGPGGLYVQAAKYILSQYV---GIDGIEGPTELVIYA-EGVPPEVAVRGALAQLEHGPTS 225

Query: 267 QVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQCVEISNQYGPE 326
              LL+P  ++ ++  E   R+            ++   ++     + + V   ++  PE
Sbjct: 226 FAYLLSPDGELLKKAEELYVRERT---------SSMGPLKVKKVGGIDEAVSFIDEIAPE 276

Query: 327 HLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADF 386
           HL +  R  RE+   + + G+V +   SP    DY +G +HVLPT G       +    F
Sbjct: 277 HLEVWGR--REVAYRVRNVGAVSVNMPSPYL--DYVAGISHVLPTGGTARWRGVITPLAF 332

Query: 387 QKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVT 424
            K + + E   E    L      LA  E    H  A+ 
Sbjct: 333 MKPIGIAEAVGE--LTLREAARKLAEYEGFKYHGEALR 368


>UniRef50_B8NVQ6 Histidinol dehydrogenase, putative n=1 Tax=Aspergillus flavus
           NRRL3357 RepID=B8NVQ6_ASPFN
          Length = 224

 Score =  229 bits (586), Expect = 1e-58,   Method: Composition-based stats.
 Identities = 78/247 (31%), Positives = 113/247 (45%), Gaps = 39/247 (15%)

Query: 187 AQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSG 246
             A+AA+A GTE++ KVD + G GN FV E KRQ+   +    ID+ AGP+EVLV+AD  
Sbjct: 11  VPAVAAIAVGTETIRKVDFLAGTGNRFVAEGKRQLFGEV---GIDLFAGPTEVLVLADET 67

Query: 247 ATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLA--ELPRAETARQALNA 304
           A P  VA DL+SQA HGPD+  +L+T    + R   E V + L+  +L   + A+ + +A
Sbjct: 68  ADPFTVAMDLISQAGHGPDTPAVLITTCPKVGRETIEIVNKLLSATDLSTPDVAKVSWDA 127

Query: 305 -SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYAS 363
              +I+   L +  E+ + Y  E + +                                 
Sbjct: 128 FGEVIIVDTLEELWELGDHYASEQVQVI-------------------------------- 155

Query: 364 GTNHVLPTYGYTATCSSLGLADFQKRMTVQELS-KEGFSALASTIETLAAAERLTAHKNA 422
           GTNH+LPT         L +  + K  T QE++  E    L       A  ER  A   +
Sbjct: 156 GTNHILPTRTTARYTGGLWVGKYLKTCTYQEVTLPESSGKLGRLCGRAARPERFEAPARS 215

Query: 423 VTLRVNA 429
             LR N 
Sbjct: 216 GDLRANR 222


>UniRef50_UPI0001909A69 histidinol dehydrogenase n=1 Tax=Rhizobium etli IE4771
           RepID=UPI0001909A69
          Length = 287

 Score =  206 bits (524), Expect = 2e-51,   Method: Composition-based stats.
 Identities = 65/178 (36%), Positives = 94/178 (52%), Gaps = 6/178 (3%)

Query: 20  LLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA---LKVSAEEIAAA 76
           L +      SE +      I+D+VKARGD AL    A   +   +    ++V+ EEI AA
Sbjct: 31  LFLTTKREVSEDVNAVARAIIDDVKARGDVALCRIFADIRRHRFSPPVPMRVTPEEIDAA 90

Query: 77  SERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSA 136
            E +  E+  A+ +A   IE+ H  Q       E   GVR       + +VGLY+PGG+A
Sbjct: 91  VEAVPSEVLGALKLAALRIESHHRRQLPKDDIYEDDLGVRLGSRWTAIEAVGLYVPGGTA 150

Query: 137 PLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCGVQDVFNVGGAQAIA 191
              S+VLM A PA +AG  ++V+  P     +   +L AA+L GV +++ VGGAQAIA
Sbjct: 151 SYPSSVLMNAVPAKVAGVDRIVIAVPATGGAVNPAVLAAARLAGVTEIYRVGGAQAIA 208


>UniRef50_C7H2J0 Histidinol dehydrogenase n=1 Tax=Faecalibacterium prausnitzii
           A2-165 RepID=C7H2J0_9FIRM
          Length = 162

 Score =  201 bits (513), Expect = 3e-50,   Method: Composition-based stats.
 Identities = 51/165 (30%), Positives = 85/165 (51%), Gaps = 4/165 (2%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              + +++    E+    ++   I A +++   V+ I+  V+ARGDEAL+EY+ KFD   
Sbjct: 1   MIKLYNFDELRPEE----ILNRDIRAEKNVEDVVDGIIAEVRARGDEALKEYALKFDGAK 56

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
           +  L+V+  EI  A   +     + +  A  NIE+FH  Q      +  +PG+   Q   
Sbjct: 57  IDDLQVTQAEIDEAFANMDPYFLETLREAAANIESFHRQQVHKNFVINEKPGIVLGQKYT 116

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIAD 167
           P+   G+Y+PGG+A   STVLM   PA +AG  ++V+ +P     
Sbjct: 117 PIEKAGVYVPGGTAAYPSTVLMDVIPAKVAGVSEIVMTTPAGKDG 161


>UniRef50_C5GHZ5 Histidinol dehydrogenase n=2 Tax=Ajellomyces dermatitidis
           RepID=C5GHZ5_AJEDR
          Length = 281

 Score =  187 bits (476), Expect = 7e-46,   Method: Composition-based stats.
 Identities = 72/270 (26%), Positives = 116/270 (42%), Gaps = 63/270 (23%)

Query: 65  ALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPV 124
           + K+S  +I AA  ++S++  + +  A  N                         +   V
Sbjct: 2   SFKLSEGDIEAAVVKVSEQTIKDIKEAQAN-----------------------GYIW--V 36

Query: 125 ASVGLYIPGGSAPLFSTVLMLATP---ASIAGCKKVVLCSPP---PIADEILYAAQLCGV 178
             + L +  G   L S+          + +AG   V +C+PP    I +       L G 
Sbjct: 37  RRIFLLVQLGRRFLPSSFHTQEVQFCNSKVAGVNHVTMCTPPINGKIPNATTATTHLVGA 96

Query: 179 QDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSE 238
            ++F +GGAQAIA +A GTES+ KVD I   G                   +D+ AGP+E
Sbjct: 97  NEIFILGGAQAIAGMAVGTESIRKVDSIAEIG-------------------VDLFAGPTE 137

Query: 239 VLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETA 298
           V             A+ LLSQAEHGPDS  +L+T + D A++V   ++R L  L  A  A
Sbjct: 138 V------------PATHLLSQAEHGPDSPAVLITTSEDSAKQVMTLIDRFLETLSTAAIA 185

Query: 299 RQALNASR-LIVTKDLAQCVEISNQYGPEH 327
             A  + R +++   + +   + ++Y  +H
Sbjct: 186 STAWRSFREVVIVDSIDEAYALGDEYAFDH 215


>UniRef50_A3J633 Histidinol dehydrogenase (Fragment) n=1 Tax=Flavobacteria bacterium
           BAL38 RepID=A3J633_9FLAO
          Length = 136

 Score =  157 bits (398), Expect = 7e-37,   Method: Composition-based stats.
 Identities = 57/140 (40%), Positives = 83/140 (59%), Gaps = 4/140 (2%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              I +      E   ++  RP  + S  +  TV  I   V+ +G++A+ +Y++ FD  T
Sbjct: 1   MKKIYN---PQPETWLEICKRPTQTFS-DVEETVKQIFKKVQQKGNKAIAKYTSFFDGVT 56

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
           +  ++V+ EEI  A + ++ ELK+A+ +A  NIE FH AQK   + VET  GV C Q  R
Sbjct: 57  LENIQVTPEEIELAKKEVATELKKAIQLAKSNIEQFHAAQKTDKIVVETTIGVTCWQEKR 116

Query: 123 PVASVGLYIPGGSAPLFSTV 142
           P+  VGLYIPGG+APLFSTV
Sbjct: 117 PIQKVGLYIPGGTAPLFSTV 136


>UniRef50_B4CYY3 NAD+ oxidoreductase n=1 Tax=Chthoniobacter flavus Ellin428
           RepID=B4CYY3_9BACT
          Length = 162

 Score =  134 bits (339), Expect = 5e-30,   Method: Composition-based stats.
 Identities = 38/129 (29%), Positives = 66/129 (51%), Gaps = 8/129 (6%)

Query: 22  MRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA--LKVSAEEIAAASER 79
           ++ +  A   + +TV D+L+ ++  GD AL E++ +F    +TA  L+V+ +       +
Sbjct: 18  LKRSAEAHPQVRKTVQDVLEAIRTEGDSALLEFTERFGGPRLTAKQLRVTGK------PK 71

Query: 80  LSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLF 139
           +  E K+A+A A  N+  F          ++   G    +   P   VG+Y+PGG+APL 
Sbjct: 72  VDAETKEAVATAHANVLAFARKSLRENWTMKNAQGGLVGERFDPFKRVGIYVPGGTAPLV 131

Query: 140 STVLMLATP 148
           ST +M  TP
Sbjct: 132 STAVMTVTP 140


>UniRef50_UPI0001696B01 histidinol dehydrogenase n=2 Tax=Listeria monocytogenes
           RepID=UPI0001696B01
          Length = 123

 Score =  119 bits (298), Expect = 3e-25,   Method: Composition-based stats.
 Identities = 38/114 (33%), Positives = 61/114 (53%)

Query: 15  EQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIA 74
           E   +L +    + S  +   V  I++ VK  GD+AL ++++KFD   +T L+V A +I 
Sbjct: 10  ELLNELKIETDTNTSIQVETEVKTIIEKVKTAGDQALFDFTSKFDGVGLTELRVPAADIQ 69

Query: 75  AASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVG 128
           AAS ++      A+  A  NIE+FH+ QK        + GV   Q+ RP+ +VG
Sbjct: 70  AASAKIEPAFLDALQQAKVNIESFHSKQKQHAFLDSEKDGVIRGQLIRPLETVG 123


>UniRef50_D1ND55 Histidinol dehydrogenase (Fragment) n=1 Tax=Haemophilus influenzae
           HK1212 RepID=D1ND55_HAEIN
          Length = 104

 Score =  117 bits (294), Expect = 8e-25,   Method: Composition-based stats.
 Identities = 43/105 (40%), Positives = 61/105 (58%), Gaps = 1/105 (0%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
             TII WN  +  ++R+++MRP     ++I + VN I +NV   GD AL E   KFD   
Sbjct: 1   MQTII-WNHLSETEKRKVIMRPVQQNGKNIQQAVNAIRENVAYNGDRALFELCEKFDGVK 59

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPV 107
           +  L VS +EI AAS R+S +L+ A+  A  NIE FH AQ+   +
Sbjct: 60  LDKLIVSVDEIQAASSRISVKLRNAIEQAKTNIEAFHKAQQNQEI 104


>UniRef50_D1KBK9 Histidinol dehydrogenase n=1 Tax=uncultured SUP05 cluster bacterium
           RepID=D1KBK9_9GAMM
          Length = 146

 Score = 82.9 bits (204), Expect = 2e-14,   Method: Composition-based stats.
 Identities = 27/115 (23%), Positives = 53/115 (46%), Gaps = 4/115 (3%)

Query: 10  NSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDK---TTVTAL 66
                +++   L+     +S  I +TV+DI+ N++  GD+AL +Y+ KFD    + ++AL
Sbjct: 8   QQADFQEKLSKLLAWESVSSTDIAQTVDDIIANIRQNGDQALIDYTNKFDGMDVSDISAL 67

Query: 67  KVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQP-GVRCQQV 120
            V    +  A + L+++ K A+  A   +  +    K   +   T+  G      
Sbjct: 68  TVDQSALKKAFDSLAEKEKTALQSAADRVRDYPPKNKSKTLGTYTEDNGTLLGSK 122


>UniRef50_C7ZHH7 Putative uncharacterized protein n=1 Tax=Nectria haematococca mpVI
           77-13-4 RepID=C7ZHH7_NECH7
          Length = 337

 Score = 76.3 bits (187), Expect = 2e-12,   Method: Composition-based stats.
 Identities = 19/69 (27%), Positives = 26/69 (37%), Gaps = 1/69 (1%)

Query: 362 ASGTNHVLPTYGYTATCSSLGLADFQKRMTVQE-LSKEGFSALASTIETLAAAERLTAHK 420
             G+NHVLPT         L +  F K  T QE + +     +       + AE    H 
Sbjct: 54  CIGSNHVLPTRKVGNYTGGLWVGKFLKTQTYQEIVDERASGEMGRLCGRCSRAENFEVHA 113

Query: 421 NAVTLRVNA 429
            +  LRV  
Sbjct: 114 RSGDLRVKK 122


>UniRef50_C0S8B7 Histidinol dehydrogenase n=1 Tax=Paracoccidioides brasiliensis Pb03
           RepID=C0S8B7_PARBP
          Length = 227

 Score = 62.4 bits (151), Expect = 3e-08,   Method: Composition-based stats.
 Identities = 27/103 (26%), Positives = 41/103 (39%), Gaps = 32/103 (31%)

Query: 239 VLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETA 298
           VL++A + A    +A+DLLSQAEH PDS  ++ T A D  +            L      
Sbjct: 128 VLIVAGNKADRFTIATDLLSQAEHSPDSPAVIFTTAEDAGK------------LETRY-- 173

Query: 299 RQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDS 341
                               ++++Y  EH+ I T+  RE    
Sbjct: 174 ------------------FRLADEYAFEHVQILTQPPREAGAR 198



 Score = 44.7 bits (105), Expect = 0.006,   Method: Composition-based stats.
 Identities = 13/43 (30%), Positives = 24/43 (55%), Gaps = 1/43 (2%)

Query: 37 NDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASER 79
            +++++++ GD A+R  S KFD    T  K S ++I A   +
Sbjct: 34 KRVIEDIRSNGDSAVRH-STKFDHWEPTPFKPSDDDIQAVIAK 75


>UniRef50_UPI00016988E7 histidinol dehydrogenase n=1 Tax=Endoriftia persephone
          'Hot96_1+Hot96_2' RepID=UPI00016988E7
          Length = 102

 Score = 57.4 bits (138), Expect = 1e-06,   Method: Composition-based stats.
 Identities = 16/73 (21%), Positives = 36/73 (49%), Gaps = 3/73 (4%)

Query: 10 NSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA---L 66
          +    + +   L+     +  ++  TVN+I+  +++RGD AL E++++FD     +   L
Sbjct: 10 SDADFQSRLDALLAWESVSDRAVNDTVNNIIAEIRSRGDAALVEFTSRFDGWQAASAADL 69

Query: 67 KVSAEEIAAASER 79
          ++    +  A E 
Sbjct: 70 ELPLSRLEQAWEH 82


>UniRef50_C8S5L7 Putative uncharacterized protein n=1 Tax=Rhodobacter sp. SW2
           RepID=C8S5L7_9RHOB
          Length = 151

 Score = 53.2 bits (127), Expect = 2e-05,   Method: Composition-based stats.
 Identities = 22/71 (30%), Positives = 36/71 (50%), Gaps = 3/71 (4%)

Query: 254 SDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELP---RAETARQALNASRLIVT 310
           +DL+ QAEHG +S V L+T    +A RV   V   +  LP   RA  A    + + +I+ 
Sbjct: 18  ADLVGQAEHGYNSPVWLVTSDRGLAARVTALVPELIVALPEPNRASAAAAWADLAEVILC 77

Query: 311 KDLAQCVEISN 321
           +D  +   + +
Sbjct: 78  EDAEEMARVFD 88


>UniRef50_D2MHU6 Putative uncharacterized protein (Fragment) n=1 Tax=Candidatus
          Poribacteria sp. WGA-A3 RepID=D2MHU6_9BACT
          Length = 74

 Score = 53.2 bits (127), Expect = 2e-05,   Method: Composition-based stats.
 Identities = 21/72 (29%), Positives = 31/72 (43%), Gaps = 3/72 (4%)

Query: 3  FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
           N I   +    E   ++  R A      I   V  IL NV+  GD A+  Y  KFD  T
Sbjct: 2  MNVISSKDKTYPEALAEVCNRAACQ-HAKIEGRVKRILKNVERNGDAAVSRYVKKFDGLT 60

Query: 63 VTA--LKVSAEE 72
          ++    +VS++ 
Sbjct: 61 LSPKKFRVSSKR 72


>UniRef50_B8FPV4 Putative cell wall binding repeat 2-containing protein n=2
           Tax=Desulfitobacterium hafniense RepID=B8FPV4_DESHD
          Length = 530

 Score = 41.6 bits (97), Expect = 0.058,   Method: Composition-based stats.
 Identities = 33/150 (22%), Positives = 60/150 (40%), Gaps = 26/150 (17%)

Query: 144 MLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVFNVGGAQAIAA------LAFGT 197
           M+A P S      +++ S   +++E+L+     G + V+ +GG  AI+A        FG 
Sbjct: 262 MVAVPLSKKYDAPILMTSSQRLSNEVLHEILNLGAETVYMIGGTGAISAEIESELQTFGI 321

Query: 198 ESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLL 257
            +     ++ G  N + T A+           I    GPS+ + +A     PD +A    
Sbjct: 322 TT----QRLAGA-NRYDTAAQ-----------IAELVGPSDRVYLAYGYGEPDAIAVSSF 365

Query: 258 SQAEHGPDSQVILLTPAADMARRVAEAVER 287
           + A        ILLT    +       +++
Sbjct: 366 AAA----QGASILLTDTHSLPEETQNRLKQ 391


Searching..................................................done


Results from round 3


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value
Sequences used in model and found again:

UniRef50_Q5E638 Histidinol dehydrogenase n=29 Tax=Bacteria RepID...   607   e-172
UniRef50_Q4QN74 Histidinol dehydrogenase n=38 Tax=cellular organ...   585   e-165
UniRef50_Q492K3 Histidinol dehydrogenase n=542 Tax=Proteobacteri...   585   e-165
UniRef50_P62456 Histidinol dehydrogenase n=127 Tax=Bacteria RepI...   582   e-165
UniRef50_D1PYE8 Histidinol dehydrogenase n=2 Tax=Prevotella RepI...   580   e-164
UniRef50_P59398 Histidinol dehydrogenase n=5 Tax=Buchnera aphidi...   579   e-164
UniRef50_O26327 Histidinol dehydrogenase n=6 Tax=Euryarchaeota R...   576   e-163
UniRef50_UPI00019859BD PREDICTED: hypothetical protein n=1 Tax=V...   574   e-162
UniRef50_Q8R882 Histidinol dehydrogenase n=7 Tax=Clostridia RepI...   573   e-162
UniRef50_D1IQ57 Histidinol dehydrogenase (Fragment) n=1 Tax=Viti...   573   e-162
UniRef50_Q39YP7 Histidinol dehydrogenase n=54 Tax=Bacteria RepID...   572   e-162
UniRef50_Q465R4 Histidinol dehydrogenase n=7 Tax=Euryarchaeota R...   571   e-161
UniRef50_Q58851 Histidinol dehydrogenase n=16 Tax=Euryarchaeota ...   569   e-161
UniRef50_Q722Y3 Histidinol dehydrogenase n=20 Tax=Firmicutes Rep...   568   e-160
UniRef50_A8RCE7 Putative uncharacterized protein n=1 Tax=Eubacte...   567   e-160
UniRef50_Q9C5U8 Histidinol dehydrogenase, chloroplastic n=34 Tax...   566   e-160
UniRef50_Q02136 Histidinol dehydrogenase n=9 Tax=Bacteria RepID=...   565   e-159
UniRef50_Q30TA4 Histidinol dehydrogenase n=16 Tax=Epsilonproteob...   564   e-159
UniRef50_D1CF70 Histidinol dehydrogenase n=1 Tax=Thermobaculum t...   564   e-159
UniRef50_Q8YSM8 Histidinol dehydrogenase 1 n=16 Tax=Bacteria Rep...   561   e-158
UniRef50_C0GFZ9 Histidinol dehydrogenase n=1 Tax=Dethiobacter al...   560   e-158
UniRef50_Q46J19 Histidinol dehydrogenase n=60 Tax=Bacteria RepID...   559   e-158
UniRef50_C6Y3G2 Histidinol dehydrogenase n=6 Tax=cellular organi...   559   e-158
UniRef50_Q6FEC8 Histidinol dehydrogenase n=50 Tax=Bacteria RepID...   557   e-157
UniRef50_B0TY46 Histidinol dehydrogenase n=2 Tax=Francisella phi...   557   e-157
UniRef50_Q4ZNV9 Histidinol dehydrogenase n=116 Tax=Bacteria RepI...   554   e-156
UniRef50_P59399 Histidinol dehydrogenase n=14 Tax=Bacteria RepID...   553   e-156
UniRef50_D0RRH1 Histidinol dehydrogenase n=1 Tax=alpha proteobac...   552   e-156
UniRef50_D0JBA3 Histidinol dehydrogenase n=2 Tax=Blattabacterium...   552   e-156
UniRef50_A9NV24 Histidinol dehydrogenase n=2 Tax=Spermatophyta R...   552   e-156
UniRef50_B9D1F9 Histidinol dehydrogenase n=2 Tax=Campylobacter R...   550   e-155
UniRef50_P00815 Histidinol dehydrogenase n=17 Tax=cellular organ...   550   e-155
UniRef50_Q2NHT1 HisD n=1 Tax=Methanosphaera stadtmanae DSM 3091 ...   548   e-154
UniRef50_C9LTV1 Histidinol dehydrogenase n=1 Tax=Selenomonas spu...   547   e-154
UniRef50_C0QG33 Histidinol dehydrogenase n=4 Tax=Deltaproteobact...   545   e-153
UniRef50_C9KKX1 Histidinol dehydrogenase n=1 Tax=Mitsuokella mul...   544   e-153
UniRef50_B2KCM4 Histidinol dehydrogenase n=1 Tax=Elusimicrobium ...   543   e-153
UniRef50_Q5FS83 Histidinol dehydrogenase n=3 Tax=Bacteria RepID=...   542   e-152
UniRef50_Q1Q2D0 Histidinol dehydrogenase n=1 Tax=Candidatus Kuen...   541   e-152
UniRef50_D2RJQ0 Histidinol dehydrogenase n=7 Tax=Firmicutes RepI...   539   e-152
UniRef50_B2A652 Histidinol dehydrogenase n=1 Tax=Natranaerobius ...   538   e-151
UniRef50_B3WED5 Histidinol dehydrogenase n=21 Tax=Bacilli RepID=...   538   e-151
UniRef50_C4V2I6 Histidinol dehydrogenase n=1 Tax=Selenomonas flu...   537   e-151
UniRef50_C3XDE7 Histidinol dehydrogenase n=1 Tax=Helicobacter bi...   537   e-151
UniRef50_Q2PPB3 Histidine biosynthesis trifunctional protein n=1...   537   e-151
UniRef50_Q3J079 Histidinol dehydrogenase 1 n=26 Tax=Proteobacter...   536   e-151
UniRef50_B3TCH3 Putative Histidinol dehydrogenase n=1 Tax=uncult...   536   e-151
UniRef50_C1PFR7 Histidinol dehydrogenase n=1 Tax=Bacillus coagul...   535   e-151
UniRef50_Q3AR25 Histidinol dehydrogenase n=13 Tax=Bacteria RepID...   535   e-150
UniRef50_Q313T7 Histidinol dehydrogenase n=7 Tax=Deltaproteobact...   534   e-150
UniRef50_Q186D5 Histidinol dehydrogenase n=9 Tax=Bacteria RepID=...   533   e-150
UniRef50_Q46WL2 Histidinol dehydrogenase 1 n=202 Tax=Bacteria Re...   531   e-149
UniRef50_Q5ZW87 Histidinol dehydrogenase n=6 Tax=Legionella RepI...   530   e-149
UniRef50_C7LV94 Histidinol dehydrogenase n=6 Tax=Desulfovibriona...   530   e-149
UniRef50_P62457 Histidinol dehydrogenase n=27 Tax=cellular organ...   529   e-149
UniRef50_D1YWF4 Histidinol dehydrogenase n=1 Tax=Methanocella pa...   528   e-148
UniRef50_Q4FQF8 Histidinol dehydrogenase n=6 Tax=Proteobacteria ...   527   e-148
UniRef50_A9A0A6 Histidinol dehydrogenase n=2 Tax=Desulfobacterac...   523   e-147
UniRef50_Q9X0D1 Histidinol dehydrogenase n=6 Tax=Thermotogaceae ...   522   e-147
UniRef50_B9KYT3 Histidinol dehydrogenase n=1 Tax=Thermomicrobium...   521   e-146
UniRef50_Q9P777 Histidinol dehydrogenase n=71 Tax=cellular organ...   518   e-145
UniRef50_Q3B5E3 Histidinol dehydrogenase n=8 Tax=Chlorobiaceae R...   517   e-145
UniRef50_Q4P7D9 Putative uncharacterized protein n=3 Tax=Eukaryo...   515   e-144
UniRef50_Q87C29 Histidinol dehydrogenase n=66 Tax=cellular organ...   515   e-144
UniRef50_Q3ZXL7 Histidinol dehydrogenase n=5 Tax=Dehalococcoides...   515   e-144
UniRef50_B3DXR9 Histidinol dehydrogenase n=1 Tax=Methylacidiphil...   513   e-144
UniRef50_A5D1M4 Histidinol dehydrogenase n=1 Tax=Pelotomaculum t...   511   e-143
UniRef50_A3EUM9 Histidinol dehydrogenase n=3 Tax=Leptospirillum ...   510   e-143
UniRef50_C7NG13 Histidinol dehydrogenase n=2 Tax=Bacteria RepID=...   510   e-143
UniRef50_C8WUX6 Histidinol dehydrogenase n=2 Tax=Alicyclobacillu...   506   e-142
UniRef50_P62460 Histidinol dehydrogenase n=15 Tax=Bacteria RepID...   506   e-142
UniRef50_Q4A044 Histidinol dehydrogenase n=62 Tax=Staphylococcus...   501   e-140
UniRef50_Q4FNE2 Histidinol dehydrogenase 1 n=3 Tax=Candidatus Pe...   501   e-140
UniRef50_C9RN89 Histidinol dehydrogenase n=1 Tax=Fibrobacter suc...   500   e-140
UniRef50_D0LM64 Histidinol dehydrogenase n=2 Tax=Nannocystineae ...   500   e-140
UniRef50_B1YL14 Histidinol dehydrogenase n=1 Tax=Exiguobacterium...   499   e-139
UniRef50_Q01ZU1 Histidinol dehydrogenase n=1 Tax=Candidatus Soli...   497   e-139
UniRef50_UPI00016BFCCC histidinol dehydrogenase n=1 Tax=Epulopis...   493   e-138
UniRef50_C4L171 Histidinol dehydrogenase n=1 Tax=Exiguobacterium...   492   e-137
UniRef50_Q5WIU9 Histidinol dehydrogenase 1 n=52 Tax=cellular org...   491   e-137
UniRef50_Q67KH6 Histidinol dehydrogenase n=1 Tax=Symbiobacterium...   491   e-137
UniRef50_B1H0F0 Histidinol dehydrogenase n=1 Tax=uncultured Term...   489   e-137
UniRef50_D1N997 Histidinol dehydrogenase n=2 Tax=Lentisphaerae R...   487   e-136
UniRef50_Q7UX39 Histidinol dehydrogenase n=6 Tax=Planctomycetace...   486   e-136
UniRef50_A6UA68 Histidinol dehydrogenase n=4 Tax=Proteobacteria ...   486   e-136
UniRef50_Q8TXG3 Histidinol dehydrogenase n=1 Tax=Methanopyrus ka...   485   e-135
UniRef50_Q483H8 Histidinol dehydrogenase 2 n=15 Tax=Proteobacter...   485   e-135
UniRef50_A1ZJE8 Histidinol dehydrogenase n=1 Tax=Microscilla mar...   483   e-135
UniRef50_UPI00017455E1 Histidinol dehydrogenase n=1 Tax=Verrucom...   482   e-134
UniRef50_B3T638 Histidinol dehydrogenase n=1 Tax=uncultured mari...   482   e-134
UniRef50_C0G418 Histidinol dehydrogenase n=2 Tax=Rhizobiales Rep...   481   e-134
UniRef50_Q13I58 Histidinol dehydrogenase n=22 Tax=cellular organ...   481   e-134
UniRef50_P73058 Histidinol dehydrogenase 1 n=11 Tax=Cyanobacteri...   479   e-133
UniRef50_D0XPF3 Histidinol dehydrogenase n=1 Tax=Brevundimonas s...   476   e-132
UniRef50_Q4JW59 Histidinol dehydrogenase n=104 Tax=Actinobacteri...   474   e-132
UniRef50_B4W8G9 Histidinol dehydrogenase n=2 Tax=Caulobacteracea...   472   e-131
UniRef50_A4QA32 Histidinol dehydrogenase n=16 Tax=cellular organ...   471   e-131
UniRef50_Q64EP7 Histidinol dehydrogenase n=2 Tax=environmental s...   471   e-131
UniRef50_D2RSH8 Histidinol dehydrogenase n=1 Tax=Haloterrigena t...   470   e-131
UniRef50_Q1AX10 Histidinol dehydrogenase n=1 Tax=Rubrobacter xyl...   469   e-131
UniRef50_A3Q131 Histidinol dehydrogenase n=6 Tax=Mycobacterium R...   469   e-131
UniRef50_A9A5X6 Histidinol dehydrogenase n=2 Tax=Thaumarchaeota ...   468   e-130
UniRef50_D1B7M0 Histidinol dehydrogenase n=2 Tax=Bacteria RepID=...   468   e-130
UniRef50_B2UMH6 Histidinol dehydrogenase n=3 Tax=Verrucomicrobia...   466   e-130
UniRef50_B6A0U7 Histidinol dehydrogenase n=1 Tax=Rhizobium legum...   464   e-129
UniRef50_B0S9F2 Histidinol dehydrogenase n=6 Tax=Leptospira RepI...   464   e-129
UniRef50_D2R570 Histidinol dehydrogenase n=1 Tax=Pirellula stale...   463   e-129
UniRef50_Q2HFX2 Putative uncharacterized protein n=1 Tax=Chaetom...   463   e-129
UniRef50_Q3IQR5 Histidinol dehydrogenase n=10 Tax=Halobacteriace...   463   e-129
UniRef50_Q5JFR5 Histidinol dehydrogenase n=9 Tax=cellular organi...   461   e-128
UniRef50_C1FAE2 Histidinol dehydrogenase n=1 Tax=Acidobacterium ...   461   e-128
UniRef50_Q82AA6 Histidinol dehydrogenase n=29 Tax=Actinobacterid...   461   e-128
UniRef50_C0GVA3 Histidinol dehydrogenase n=1 Tax=Desulfonatronos...   457   e-127
UniRef50_Q5YYQ0 Histidinol dehydrogenase n=8 Tax=Actinomycetales...   456   e-127
UniRef50_Q1D4L9 Histidinol dehydrogenase n=2 Tax=Cystobacterinea...   456   e-126
UniRef50_B8E2C3 Histidinol dehydrogenase n=1 Tax=Dictyoglomus tu...   455   e-126
UniRef50_B5YE85 Histidinol dehydrogenase n=1 Tax=Dictyoglomus th...   454   e-126
UniRef50_O33775 Histidinol dehydrogenase n=12 Tax=Sulfolobaceae ...   450   e-125
UniRef50_Q1IKB6 Histidinol dehydrogenase n=1 Tax=Candidatus Kori...   445   e-123
UniRef50_Q46N53 Histidinol dehydrogenase 2 n=50 Tax=root RepID=H...   444   e-123
UniRef50_C7LZ86 Histidinol dehydrogenase n=1 Tax=Acidimicrobium ...   441   e-122
UniRef50_A9G5W4 HisD protein n=1 Tax=Sorangium cellulosum 'So ce...   438   e-121
UniRef50_Q0AP81 Histidinol dehydrogenase, Histidinol-phosphatase...   436   e-121
UniRef50_A0R401 Histidinol dehydrogenase n=2 Tax=Actinomycetales...   431   e-119
UniRef50_C7RAI8 Histidinol dehydrogenase n=1 Tax=Kangiella koree...   426   e-118
UniRef50_B1ZNB2 Histidinol dehydrogenase n=3 Tax=Verrucomicrobia...   424   e-117
UniRef50_C1A4M1 Histidinol dehydrogenase n=1 Tax=Gemmatimonas au...   419   e-116
UniRef50_C9SQK1 Histidine biosynthesis trifunctional protein n=1...   412   e-113
UniRef50_B5YLM0 Histidinol dehydrogenase n=1 Tax=Thalassiosira p...   404   e-111
UniRef50_UPI0001C3165E histidinol dehydrogenase n=1 Tax=Conexiba...   388   e-106
UniRef50_C6UN35 Histidinal/histidinol dehydrogenase n=1 Tax=Cand...   380   e-104
UniRef50_A8M914 Histidinol dehydrogenase n=1 Tax=Caldivirga maqu...   378   e-103
UniRef50_B7FPZ7 Histidinol dehydrogenase (Fragment) n=3 Tax=Euka...   377   e-103
UniRef50_A8A9G5 Histidinol dehydrogenase n=1 Tax=Ignicoccus hosp...   341   3e-92
UniRef50_B9NIZ3 Histidinol dehydrogenase n=1 Tax=Populus trichoc...   327   8e-88
UniRef50_P72946 Putative histidinol dehydrogenase 2 n=1 Tax=Syne...   319   1e-85
UniRef50_Q8ZY17 Histidinol dehydrogenase n=5 Tax=Thermoproteacea...   298   3e-79
UniRef50_B8NVQ6 Histidinol dehydrogenase, putative n=1 Tax=Asper...   224   5e-57
UniRef50_UPI0001909A69 histidinol dehydrogenase n=1 Tax=Rhizobiu...   211   3e-53
UniRef50_C5GHZ5 Histidinol dehydrogenase n=2 Tax=Ajellomyces der...   209   2e-52
UniRef50_C7H2J0 Histidinol dehydrogenase n=1 Tax=Faecalibacteriu...   205   2e-51
UniRef50_A3J633 Histidinol dehydrogenase (Fragment) n=1 Tax=Flav...   159   2e-37
UniRef50_B4CYY3 NAD+ oxidoreductase n=1 Tax=Chthoniobacter flavu...   133   1e-29
UniRef50_UPI0001696B01 histidinol dehydrogenase n=2 Tax=Listeria...   120   1e-25
UniRef50_D1ND55 Histidinol dehydrogenase (Fragment) n=1 Tax=Haem...   111   6e-23
UniRef50_D1KBK9 Histidinol dehydrogenase n=1 Tax=uncultured SUP0...    96   3e-18
UniRef50_C7ZHH7 Putative uncharacterized protein n=1 Tax=Nectria...    81   7e-14
UniRef50_UPI00016988E7 histidinol dehydrogenase n=1 Tax=Endorift...    66   2e-09
UniRef50_C0S8B7 Histidinol dehydrogenase n=1 Tax=Paracoccidioide...    63   2e-08
UniRef50_D2MHU6 Putative uncharacterized protein (Fragment) n=1 ...    58   7e-07
UniRef50_C8S5L7 Putative uncharacterized protein n=1 Tax=Rhodoba...    54   1e-05

Sequences not found previously or not previously below threshold:

UniRef50_B8FPV4 Putative cell wall binding repeat 2-containing p...    41   0.096


CONVERGED!
>UniRef50_Q5E638 Histidinol dehydrogenase n=29 Tax=Bacteria RepID=HISX_VIBF1
          Length = 439

 Score =  607 bits (1567), Expect = e-172,   Method: Composition-based stats.
 Identities = 275/429 (64%), Positives = 328/429 (76%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
              + W S +  QQ  +L RPAI+   +IT  V  +++ VK  GD  +   + KFD    
Sbjct: 1   MKTLVWQSLSDSQQDTVLQRPAITEGANITAAVTSVINTVKQEGDAGVFALTEKFDGVKP 60

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRP 123
            +++VS  EI AAS+RLS+E+K A+  A  NI  FH AQK  PV VETQPGV C+Q+T P
Sbjct: 61  DSIRVSNAEIEAASDRLSEEMKTALKQAYSNISKFHQAQKPQPVKVETQPGVICEQITMP 120

Query: 124 VASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVFN 183
           +  VGLYIPGGSAPL STVLML  PA IAGC KVVLCSPPPIADEILY A+LC + +V+N
Sbjct: 121 INKVGLYIPGGSAPLPSTVLMLGIPAQIAGCHKVVLCSPPPIADEILYVAKLCKIDEVYN 180

Query: 184 VGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIA 243
           +GGAQA+AA+A+GTESV KVDKIFGPGNA+VTEAKRQVS    GAAIDMPAGPSEVLVIA
Sbjct: 181 IGGAQAVAAMAYGTESVSKVDKIFGPGNAYVTEAKRQVSNDFRGAAIDMPAGPSEVLVIA 240

Query: 244 DSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALN 303
           D  A PDF+A+DLLSQAEHGPDSQV+L+TP+  +A +VA+AVERQL EL R + ARQAL 
Sbjct: 241 DESADPDFIAADLLSQAEHGPDSQVVLVTPSPIIADQVADAVERQLKELSREDIARQALG 300

Query: 304 ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYAS 363
           +S LIV   L QCV ISN YGPEHLI+QT+N REL+  + +AGS+FLGD+SPESAGDYAS
Sbjct: 301 SSLLIVADSLTQCVSISNFYGPEHLIVQTKNPRELLPLLDNAGSIFLGDYSPESAGDYAS 360

Query: 364 GTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAV 423
           GTNHVLPTYGYT T SSLGLADF KRMTVQEL+ +G   LA T+ T+A AE L AHK AV
Sbjct: 361 GTNHVLPTYGYTRTYSSLGLADFSKRMTVQELTADGLKGLAPTVVTMAEAEGLDAHKRAV 420

Query: 424 TLRVNALKE 432
           T+R+  L +
Sbjct: 421 TIRIEKLAQ 429


>UniRef50_Q4QN74 Histidinol dehydrogenase n=38 Tax=cellular organisms
           RepID=HISX_HAEI8
          Length = 427

 Score =  585 bits (1509), Expect = e-165,   Method: Composition-based stats.
 Identities = 274/429 (63%), Positives = 330/429 (76%), Gaps = 3/429 (0%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
             TII WN  +  ++R+++MRP     E+I + VN I +NV   GD AL E   KFD   
Sbjct: 1   MQTII-WNHLSETEKRKVIMRPVQQNGENIQQAVNAIRENVAYNGDRALFELCEKFDGVK 59

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
           +  L VSA+EI AAS R+S +L+ A+  A  NIE FH AQ+   +D+E Q GVRCQ VTR
Sbjct: 60  LDKLIVSADEIQAASSRISVKLRNAIEQAKTNIEAFHKAQQNQEIDLEIQEGVRCQVVTR 119

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVF 182
           P++ VGLYIPGGSAPLFSTVLMLA PA IAGCKK+VLCSPPPI+DEILY A LCGV+ ++
Sbjct: 120 PISCVGLYIPGGSAPLFSTVLMLAIPAKIAGCKKIVLCSPPPISDEILYTAHLCGVETIY 179

Query: 183 NVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVI 242
            +GGAQA+ A+A GTESV KVDKIFGPGNAFVTEAKRQV+Q  +  AIDMPAGPSEVLVI
Sbjct: 180 AIGGAQAVFAMAQGTESVAKVDKIFGPGNAFVTEAKRQVAQ--NSTAIDMPAGPSEVLVI 237

Query: 243 ADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL 302
           AD  A P+FVASDLLSQAEHG DSQVIL+     +A+  A A+ERQLA LPRAETAR+AL
Sbjct: 238 ADESADPEFVASDLLSQAEHGADSQVILVATCETLAKETALAIERQLALLPRAETARKAL 297

Query: 303 NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYA 362
           N SR+ + + L Q VEISN+Y PEHLI+QT+NAR+L+  + +AGS+FLG +SPES GDYA
Sbjct: 298 NHSRIFIAESLEQAVEISNEYAPEHLIVQTKNARKLLPYLDNAGSIFLGAYSPESMGDYA 357

Query: 363 SGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNA 422
           SGTNHVLPTYGYT T SSLGLADF KRMTVQEL+ +GF  LA T+E +A AE+L AHK A
Sbjct: 358 SGTNHVLPTYGYTKTYSSLGLADFSKRMTVQELTPKGFKNLAETVEVMAEAEQLAAHKMA 417

Query: 423 VTLRVNALK 431
           V++R+  L 
Sbjct: 418 VSVRLAKLN 426


>UniRef50_Q492K3 Histidinol dehydrogenase n=542 Tax=Proteobacteria RepID=HISX_BLOPB
          Length = 443

 Score =  585 bits (1508), Expect = e-165,   Method: Composition-based stats.
 Identities = 232/427 (54%), Positives = 305/427 (71%)

Query: 7   IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTAL 66
           I WN C+  +Q++LL RP  +    I   V +IL  V   GD AL +++  FD    T L
Sbjct: 10  IYWNDCSKSEQKKLLTRPINNKLNDIYINVKNILTKVYNEGDRALFKFNFDFDNVQTTQL 69

Query: 67  KVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVAS 126
           ++  E I  +   LS+E+KQA+  A+ NI  FH AQ    + VET PGV CQQ+ RP+  
Sbjct: 70  QIPTEIIMNSGRNLSNEIKQAIHTAMTNITRFHQAQCYSEIIVETLPGVYCQQIIRPLNI 129

Query: 127 VGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVFNVGG 186
           VGLY+PGG+APL STV+ML  PA IA CK+V+LCSPPPI D I+Y AQLCG+ +++ +GG
Sbjct: 130 VGLYVPGGTAPLLSTVMMLGVPARIAKCKRVILCSPPPIPDVIIYTAQLCGIDEIYQIGG 189

Query: 187 AQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSG 246
           +Q+IAA+ FGTES+PKVDKIFGPGN +VTEAKRQ++   +GAAIDM AGPSE+L+IAD+ 
Sbjct: 190 SQSIAAMGFGTESIPKVDKIFGPGNIWVTEAKRQINLAPNGAAIDMLAGPSEILIIADNT 249

Query: 247 ATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASR 306
           A P F+A+DLLSQ+EHGPDS  IL+TP + +A +  + + +QL  LPR +  R  L  SR
Sbjct: 250 ANPIFIAADLLSQSEHGPDSHAILITPYSCIAEKTKKELHKQLKILPRNDIVRNVLLNSR 309

Query: 307 LIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTN 366
           +I+T +L +C  ISN Y PEHLIIQ  NA + +  IT+AGS+FLG+WSPE+AGDYASG N
Sbjct: 310 MIITNNLMECFSISNSYAPEHLIIQIENASDYLHYITNAGSIFLGNWSPETAGDYASGPN 369

Query: 367 HVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
           HVLPTYG     S LG+ DFQKRM+VQ+L++ G   L+STI TL   E+L AH+ A+T R
Sbjct: 370 HVLPTYGRAVATSGLGVIDFQKRMSVQQLTQNGLLQLSSTITTLTQIEQLKAHEYAITHR 429

Query: 427 VNALKEQ 433
           +N +KEQ
Sbjct: 430 INYIKEQ 436


>UniRef50_P62456 Histidinol dehydrogenase n=127 Tax=Bacteria RepID=HISX_BACC1
          Length = 429

 Score =  582 bits (1501), Expect = e-165,   Method: Composition-based stats.
 Identities = 169/417 (40%), Positives = 250/417 (59%), Gaps = 7/417 (1%)

Query: 19  QLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASE 78
           +LL   A    E++ R V++I+ NV+  GDEAL  Y+ KFD   +   +VS EE   AS 
Sbjct: 16  KLLRENANIIEETVQRNVSEIVRNVRESGDEALSFYTKKFDGVKIKEFRVSEEEEKRASM 75

Query: 79  RLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPL 138
            + +   +A+  A KNI ++H  QK   +      G+   Q+ RP+ +VG+Y+PGG+A  
Sbjct: 76  FVENSFLEALQEAKKNIISYHEKQKRQSMFDCASEGIIRGQIIRPLENVGVYVPGGTASY 135

Query: 139 FSTVLMLATPASIAGCKKVVLCSPP---PIADEILYAAQLCGVQDVFNVGGAQAIAALAF 195
            S+VLM   PA +AG KK+V+ +PP    I   IL AA L GV +++ +GGAQAIAALA+
Sbjct: 136 PSSVLMNVLPAKLAGVKKIVMVTPPREGGIDPHILVAASLAGVDEIYTIGGAQAIAALAY 195

Query: 196 GTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASD 255
           GTES+PKVDKI GPGN +V  AKR+V   ++   IDM AGPSE++VIAD      ++A+D
Sbjct: 196 GTESIPKVDKIVGPGNLYVALAKREVYGIVN---IDMIAGPSEIVVIADETGNAKYIAAD 252

Query: 256 LLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALN-ASRLIVTKDLA 314
           LLSQAEH   +  I +T   ++A++V + +ERQL  LPR+E AR+++N    + +   + 
Sbjct: 253 LLSQAEHDERATAICITTNIELAKKVEKEIERQLETLPRSEIARESINRNGAIFIVPSID 312

Query: 315 QCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGY 374
           + +++SN+  PEHL +  +     +  +  AGS+FLG ++PE  GDY +G NHVLPT G 
Sbjct: 313 EALQLSNEIAPEHLELHIKEPMNALAYVKHAGSIFLGPYAPEPLGDYLAGPNHVLPTSGT 372

Query: 375 TATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNALK 431
               S L + DF K+ +    ++E    +   I  LA  E L AH  A+ +R    +
Sbjct: 373 ARFFSPLSVDDFVKKSSFLSYTEEALRDVQHHIVELANKEGLHAHARAIQIRFEEEE 429


>UniRef50_D1PYE8 Histidinol dehydrogenase n=2 Tax=Prevotella RepID=D1PYE8_9BACT
          Length = 444

 Score =  580 bits (1496), Expect = e-164,   Method: Composition-based stats.
 Identities = 212/432 (49%), Positives = 287/432 (66%), Gaps = 9/432 (2%)

Query: 6   IIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA 65
           II +   +  +  ++L RP +  S  +  TVN+IL +VK+RGDEA+R Y A FD+  +  
Sbjct: 3   IIKYPPKS--EWSRILKRPHLDVS-QLNETVNEILSDVKSRGDEAVRHYEALFDQADLGD 59

Query: 66  LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVA 125
           L VS EEI  A   +S +LK+A+ +A  NI  FH +Q      VET  GV C Q +  + 
Sbjct: 60  LTVSDEEIDEAMSMVSTDLKEALELAYHNISKFHESQLFHGKMVETAQGVVCWQKSVAIE 119

Query: 126 SVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQDV 181
            VGLYIPGG+APLFSTVLMLATPA IAGCK +VLC+PP     I   IL AA + GV  +
Sbjct: 120 KVGLYIPGGTAPLFSTVLMLATPAKIAGCKDIVLCTPPNHDGKIHPAILVAAHIAGVDRI 179

Query: 182 FNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLV 241
           F  GG QAI A+A+GT+++PKV KIFGPGN +V  AK+QVS  L   AIDMPAGPSEV V
Sbjct: 180 FKAGGVQAIGAMAYGTQTIPKVYKIFGPGNQYVMAAKQQVS--LHDVAIDMPAGPSEVCV 237

Query: 242 IADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQA 301
           IAD G+  +FVA+DLLSQAEHG DSQV+L++ + ++   V   VERQL  LPR E A  A
Sbjct: 238 IADEGSNAEFVAADLLSQAEHGSDSQVMLISTSDNLITEVRSQVERQLENLPRREIASDA 297

Query: 302 LNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDY 361
           L  S+ ++  D+ + + +SN+Y PEHLI+ T N  E+ D + +AGSVF+G WS ESAGDY
Sbjct: 298 LKNSKFVLVHDMDEAMRLSNEYAPEHLILSTGNFEEMADKVVNAGSVFMGKWSCESAGDY 357

Query: 362 ASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKN 421
           ASGTNH LPT+ Y    S + L  + +++T Q+LS+ G S++ + +  +A  E L AH +
Sbjct: 358 ASGTNHTLPTHQYALAYSGVNLDSYCRKITFQQLSENGVSSIGNAVVRMAEDEGLEAHAH 417

Query: 422 AVTLRVNALKEQ 433
           A+ +R+  + ++
Sbjct: 418 AMRIRLKKVDDK 429


>UniRef50_P59398 Histidinol dehydrogenase n=5 Tax=Buchnera aphidicola
           RepID=HISX_BUCBP
          Length = 435

 Score =  579 bits (1494), Expect = e-164,   Method: Composition-based stats.
 Identities = 215/431 (49%), Positives = 305/431 (70%)

Query: 2   SFNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKT 61
            +  II W SC+ +++R++L RP ++ +  I   V +I+ NVK  GD+AL +Y+  FDK 
Sbjct: 3   VYIPIIYWKSCSEKEKREILFRPVVNDNSQIKEVVKEIITNVKNSGDKALYDYTKTFDKI 62

Query: 62  TVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVT 121
            + +++VS  EI  +   +++E++++++VA  NI+ FH  Q    V++E QPGV C+Q+ 
Sbjct: 63  RLESIQVSYGEIVDSDSFVNEEIQKSISVAKNNIKIFHEKQTHNVVNIEIQPGVFCRQII 122

Query: 122 RPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDV 181
           RP+ SVGLYIPGG APL STVLMLA PA I GCK ++LCSPPPI  EILYA+++CG+ ++
Sbjct: 123 RPIQSVGLYIPGGCAPLVSTVLMLAIPAKIVGCKNIILCSPPPITKEILYASKICGIHNI 182

Query: 182 FNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLV 241
           F VGGAQAIAA+AFGT+++PKV+KIFGPGN +VTEAK Q++  L+  +IDM AGPSE+L+
Sbjct: 183 FQVGGAQAIAAMAFGTKTIPKVNKIFGPGNVYVTEAKLQINALLNDLSIDMLAGPSEILI 242

Query: 242 IADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQA 301
           IAD  A    +ASD LSQ EHG  SQ IL+TP+ D+A  V   +  QL  L R +   ++
Sbjct: 243 IADFKANACIIASDFLSQMEHGIYSQAILVTPSYDLACNVIFEINIQLKNLSRKKVINKS 302

Query: 302 LNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDY 361
           L  SR+IVTK L +C EISN Y PEHLIIQ  N+  L+  + +AGS+FLG WS  ++GDY
Sbjct: 303 LKYSRIIVTKTLLECFEISNLYAPEHLIIQCENSNRLLVYVINAGSIFLGRWSAVASGDY 362

Query: 362 ASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKN 421
            +GTNHVLPTYG     S L + DFQK ++VQ+L ++G   ++S+I +L+  ER+ AH N
Sbjct: 363 VTGTNHVLPTYGSAIVNSGLTVMDFQKIISVQKLDQQGLIDVSSSIISLSEVERMDAHTN 422

Query: 422 AVTLRVNALKE 432
           ++  R+ AL++
Sbjct: 423 SIKQRLIALQD 433


>UniRef50_O26327 Histidinol dehydrogenase n=6 Tax=Euryarchaeota RepID=HISX_METTH
          Length = 426

 Score =  576 bits (1485), Expect = e-163,   Method: Composition-based stats.
 Identities = 181/430 (42%), Positives = 256/430 (59%), Gaps = 9/430 (2%)

Query: 5   TIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVT 64
            ++        +  +L+ R  +     +   V DI+  V+  GD+ALRE + +FD  TV 
Sbjct: 1   MLMKITEFDYRRISELVERARLDVD-DVLGPVADIISMVRDGGDDALRELTGRFDGVTVE 59

Query: 65  ALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPV 124
             +VS EEI  A + L   +K+A+  A  NIE FH  Q       E +PGV   Q+ RP+
Sbjct: 60  NFRVSREEIEEAHKNLEPGVKEALREAASNIEEFHRMQMPSGWMSEVRPGVMAGQLVRPI 119

Query: 125 ASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQD 180
            SVG YIPGG A   ST+LM   PA IAG +++V C+PP     + D +L AA + G  +
Sbjct: 120 DSVGCYIPGGRAVYPSTILMTVIPARIAGVERIVCCTPPAQDGSVPDAVLVAADMAGASE 179

Query: 181 VFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVL 240
           ++ VGGAQA+AA+A+GTE++  VDKI GPGN FVT AK+ V   +D   ID PAGPSEVL
Sbjct: 180 IYRVGGAQAVAAMAYGTETIRPVDKIVGPGNIFVTAAKKLVYGEVD---IDFPAGPSEVL 236

Query: 241 VIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQ 300
           +IAD  A+P+++A ++L+QAEH P +  +L+T + D+A  V E V   +  + RA   R+
Sbjct: 237 IIADETASPEYIALEILAQAEHDPQAASVLVTDSRDLALEVKEMVHENIKYMERANIIRE 296

Query: 301 ALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAG 359
           +L     +++T D+ + V+ SN Y PEHL+I T +  E ++ I +AGS+FLG+ SP +AG
Sbjct: 297 SLERYGMIVLTADIDEAVDFSNAYAPEHLVIMTDSPEETLEGIRNAGSIFLGELSPVAAG 356

Query: 360 DYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAH 419
           DY SGTNHVLPT G     S L    F K+ TVQ ++KEG   L  T+  LA  E L AH
Sbjct: 357 DYGSGTNHVLPTSGCARMYSGLSTESFIKKPTVQRITKEGLRNLQGTVLKLAEYEGLHAH 416

Query: 420 KNAVTLRVNA 429
             +   R+  
Sbjct: 417 AESFRRRLRD 426


>UniRef50_UPI00019859BD PREDICTED: hypothetical protein n=1 Tax=Vitis vinifera
           RepID=UPI00019859BD
          Length = 524

 Score =  574 bits (1480), Expect = e-162,   Method: Composition-based stats.
 Identities = 207/435 (47%), Positives = 272/435 (62%), Gaps = 8/435 (1%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
                 +  +  +   L  RP I  S SI   V+ I+D+V++RGD A+++Y+ +FDK  +
Sbjct: 87  MKSYRLSELSQAEVNSLKARPRIDFS-SIFNVVHPIVDDVRSRGDAAVKDYTTRFDKVEL 145

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRP 123
             L  +  E+      L   +K+A  VA  NI  FH AQK     VE   GV+C++V R 
Sbjct: 146 DRLIENVAELPD--PELDAGIKEAFDVAYDNIFAFHAAQKSAEKIVENMKGVKCKRVARS 203

Query: 124 VASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQ 179
           +ASVGLY+PGG+A L ST LML+ PA IAGCK VVL +PP     I  E+LY A+  GV 
Sbjct: 204 IASVGLYVPGGTAVLPSTALMLSVPAQIAGCKTVVLATPPSQDGGICKEVLYCAKKAGVT 263

Query: 180 DVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEV 239
            +   GGAQAIAA+A+GT S PKV+KIFGPGN +VT AK  +       +IDMPAGPSEV
Sbjct: 264 HILKAGGAQAIAAMAWGTTSCPKVEKIFGPGNQYVTAAKMILQNSEAMVSIDMPAGPSEV 323

Query: 240 LVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADM-ARRVAEAVERQLAELPRAETA 298
           LVIAD  A P  +A+DLLSQAEHGPDSQV+L+     +  R + E + +Q   LPR E A
Sbjct: 324 LVIADKHANPVHIAADLLSQAEHGPDSQVVLVIAGDGVDLRAIEEEISKQCQSLPRGEFA 383

Query: 299 RQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESA 358
            +AL+ S  +  +++ + +  SN Y PEHLII  ++A +  + I +AGSVFLG W+PES 
Sbjct: 384 SKALSHSFTVFARNMVEAISFSNLYAPEHLIINVKDAEKWENFIENAGSVFLGQWTPESV 443

Query: 359 GDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTA 418
           GDYASGTNHVLPTYGY      L L  F K MTVQ L++EG   L   +E +A  E L A
Sbjct: 444 GDYASGTNHVLPTYGYARMYGGLSLDSFLKYMTVQSLTEEGLRKLGPYVEAMAEVEGLEA 503

Query: 419 HKNAVTLRVNALKEQ 433
           HK AVTLR+  ++ +
Sbjct: 504 HKRAVTLRLQDIEAR 518


>UniRef50_Q8R882 Histidinol dehydrogenase n=7 Tax=Clostridia RepID=HISX_THETN
          Length = 430

 Score =  573 bits (1479), Expect = e-162,   Method: Composition-based stats.
 Identities = 180/431 (41%), Positives = 266/431 (61%), Gaps = 10/431 (2%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              + D+           +   +   ++ I + V DI++NV+ R D+AL EY+  +D   
Sbjct: 1   MIEMFDFTKEVDIGIFNKIQNRSKLENKEIAKRVEDIIENVRERKDKALFEYTYMYDGIN 60

Query: 63  VTA--LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQV 120
           + +  +KV  EEI  A E + ++  +A+  A+KNI  FH  QK     ++ + G+   QV
Sbjct: 61  LNSETVKVKEEEIKRAYEEVKEDFLKALDKAIKNITEFHEKQKEKTW-MDFKEGIVYGQV 119

Query: 121 TRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCG 177
            RP++SVG+Y+PGG+A   S+VLM   PA +AG +++V+ SP     I+  +L AA   G
Sbjct: 120 LRPLSSVGIYVPGGTASYPSSVLMNGIPAKVAGVERIVMVSPAGKKGISPYVLVAADKIG 179

Query: 178 VQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPS 237
           +++++ +GGAQA+AALAFGTES+PKVDKI GPGN +V  AKR +   +D   IDM AGPS
Sbjct: 180 IKEIYKIGGAQAVAALAFGTESIPKVDKIVGPGNIYVAMAKRALYGYVD---IDMVAGPS 236

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAET 297
           E+LVIAD  A+P +VA+DLLSQAEH   +  IL+T + ++A +V + +ERQ+  L R E 
Sbjct: 237 EILVIADESASPKYVAADLLSQAEHDVMASSILVTTSKELAEKVKKEIERQMEYLERKEI 296

Query: 298 ARQALNA-SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPE 356
             ++L     +IV  +L + + I+N+  PEHL +   N  E++  I +AG+VFLG++SPE
Sbjct: 297 IAESLKNFGAIIVIDNLKEAIGIANEIAPEHLELVIENPFEILGEIKNAGAVFLGEFSPE 356

Query: 357 SAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERL 416
             GDY +G NHVLPT G     S L + DF K+M V   SKE  S++   + TLA AE L
Sbjct: 357 PLGDYLAGPNHVLPTSGTARFFSPLSVRDFVKKMNVLYYSKEALSSVKDDVITLAEAEEL 416

Query: 417 TAHKNAVTLRV 427
           TAH N+V +R 
Sbjct: 417 TAHANSVKVRF 427


>UniRef50_D1IQ57 Histidinol dehydrogenase (Fragment) n=1 Tax=Vitis vinifera
           RepID=D1IQ57_VITVI
          Length = 546

 Score =  573 bits (1477), Expect = e-162,   Method: Composition-based stats.
 Identities = 207/435 (47%), Positives = 272/435 (62%), Gaps = 8/435 (1%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
                 +  +  +   L  RP I  S SI   V+ I+D+V++RGD A+++Y+ +FDK  +
Sbjct: 109 MKSYRLSELSQAEVNSLKARPRIDFS-SIFNVVHPIVDDVRSRGDAAVKDYTTRFDKVEL 167

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRP 123
             L  +  E+      L   +K+A  VA  NI  FH AQK     VE   GV+C++V R 
Sbjct: 168 DRLIENVAELPD--PELDAGIKEAFDVAYDNIFAFHAAQKSAEKIVENMKGVKCKRVARS 225

Query: 124 VASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQ 179
           +ASVGLY+PGG+A L ST LML+ PA IAGCK VVL +PP     I  E+LY A+  GV 
Sbjct: 226 IASVGLYVPGGTAVLPSTALMLSVPAQIAGCKTVVLATPPSQDGGICKEVLYCAKKAGVT 285

Query: 180 DVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEV 239
            +   GGAQAIAA+A+GT S PKV+KIFGPGN +VT AK  +       +IDMPAGPSEV
Sbjct: 286 HILKAGGAQAIAAMAWGTTSCPKVEKIFGPGNQYVTAAKMILQNSEAMVSIDMPAGPSEV 345

Query: 240 LVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADM-ARRVAEAVERQLAELPRAETA 298
           LVIAD  A P  +A+DLLSQAEHGPDSQV+L+     +  R + E + +Q   LPR E A
Sbjct: 346 LVIADKHANPVHIAADLLSQAEHGPDSQVVLVIAGDGVDLRAIEEEISKQCQSLPRGEFA 405

Query: 299 RQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESA 358
            +AL+ S  +  +++ + +  SN Y PEHLII  ++A +  + I +AGSVFLG W+PES 
Sbjct: 406 SKALSHSFTVFARNMVEAISFSNLYAPEHLIINVKDAEKWENFIENAGSVFLGQWTPESV 465

Query: 359 GDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTA 418
           GDYASGTNHVLPTYGY      L L  F K MTVQ L++EG   L   +E +A  E L A
Sbjct: 466 GDYASGTNHVLPTYGYARMYGGLSLDSFLKYMTVQSLTEEGLRKLGPYVEAMAEVEGLEA 525

Query: 419 HKNAVTLRVNALKEQ 433
           HK AVTLR+  ++ +
Sbjct: 526 HKRAVTLRLQDIEAR 540


>UniRef50_Q39YP7 Histidinol dehydrogenase n=54 Tax=Bacteria RepID=HISX_GEOMG
          Length = 436

 Score =  572 bits (1476), Expect = e-162,   Method: Composition-based stats.
 Identities = 172/437 (39%), Positives = 251/437 (57%), Gaps = 10/437 (2%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT- 62
              +D      + +   ++         + + V DI+ +V+ARGDEAL EY+ +FD+   
Sbjct: 1   MKFLDIRDTNFDMEFAAILARGEETGREVEQVVLDIIADVRARGDEALLEYTRRFDRLEA 60

Query: 63  --VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQV 120
             V +L+V+ +E+  A  R+ DE   A+ +AV+ +  FH  QK        +P +   Q+
Sbjct: 61  DSVASLQVTEDEVDYAFARVKDEEIAALKLAVERVARFHEKQKQETWLSTGEPDILLGQM 120

Query: 121 TRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCG 177
             P+  VG+Y+PGG A   S+V+M A PA +AG  +VV+ +P P   I   +L AA+  G
Sbjct: 121 VTPLERVGIYVPGGKASYPSSVIMNAVPARVAGVGEVVMVAPTPGGEINPHVLVAARFSG 180

Query: 178 VQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPS 237
           V  +F +GGAQA+AALA+GT +VPKVDKI GPGN +V  AK+ V  ++    IDM AGPS
Sbjct: 181 VDRIFRLGGAQAVAALAYGTATVPKVDKITGPGNIYVATAKKLVFGQV---GIDMIAGPS 237

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAET 297
           E+LVI D   TP  +A+DLLSQAEH   +  IL+T       RVA  VERQLAEL R   
Sbjct: 238 EILVINDGSGTPAHIAADLLSQAEHDELASSILITTDRGFGERVAAEVERQLAELSRETI 297

Query: 298 ARQALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPE 356
           AR++      +IV   L + +  SN+  PEHL +   N  +++  I +AG++FLG ++PE
Sbjct: 298 ARRSWETYGAVIVAGSLDEAIAFSNRIAPEHLELAVTNPFDVLPKIRNAGAIFLGHFTPE 357

Query: 357 SAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERL 416
           +AGDY +G NH LPT G     S L + DF K+ ++   S+ G + L   I  +A  E L
Sbjct: 358 AAGDYLAGPNHTLPTGGTARFFSPLSVDDFVKKSSIVYFSESGLNRLGGGIVRIAELEGL 417

Query: 417 TAHKNAVTLRVNALKEQ 433
            AH  +V++R+    E 
Sbjct: 418 EAHGRSVSVRLKGEGEA 434


>UniRef50_Q465R4 Histidinol dehydrogenase n=7 Tax=Euryarchaeota RepID=HISX_METBF
          Length = 433

 Score =  571 bits (1472), Expect = e-161,   Method: Composition-based stats.
 Identities = 182/432 (42%), Positives = 252/432 (58%), Gaps = 10/432 (2%)

Query: 1   MSFNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDK 60
           M        +  +  + ++LL R   S  E + +TV+ +L +V+ +GD ALREY+AKFDK
Sbjct: 1   MVMMLFKKLSDVSEAEMQKLLSRG--SGLEDVAKTVSTVLSDVRTKGDSALREYTAKFDK 58

Query: 61  TTVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLP-PVDVETQPGVRCQQ 119
             +    VS EE   A   +S EL   +  A  NI  FH AQ       +E +PG+   Q
Sbjct: 59  VELANFGVSEEEFQQALSGISPELLDHLKSAAANIRAFHEAQLPKATWFMELKPGIVLGQ 118

Query: 120 VTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQL 175
              P+ SVG Y PGG A   STVLM   PA +AG ++V++C+PP     +    L AA++
Sbjct: 119 KATPLESVGAYAPGGRASYPSTVLMTVIPARVAGVEQVIVCTPPRPDGSVHPLTLAAAKV 178

Query: 176 CGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAG 235
            G   VF +GG QAI ++A+GTE+VPKVDKI GPGN FVT AK Q+    D A ID PAG
Sbjct: 179 AGADKVFKLGGVQAIGSMAYGTETVPKVDKIVGPGNVFVTAAKMQIR---DVAEIDFPAG 235

Query: 236 PSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRA 295
           PSEVL+IAD  A    VASD+L+Q+EH P+S  IL+T +  +A  V   V  Q  +  R+
Sbjct: 236 PSEVLIIADESADAVMVASDILAQSEHDPNSVSILVTGSDTLAEAVKREVLVQAEQAARS 295

Query: 296 ETARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSP 355
              + +L  + +++   L QC+  SN++ PEHL I   +   ++D I +AGS+F+G++SP
Sbjct: 296 SIIKSSLENAAILIADSLEQCIGFSNKFAPEHLEIMVADPDFVLDRIKNAGSIFIGNYSP 355

Query: 356 ESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAER 415
              GDYASGTNHVLPT GY    S L +  F K  ++Q +SK G  +L  T+  LA  E 
Sbjct: 356 VPVGDYASGTNHVLPTSGYARVYSGLNINHFIKYSSIQRISKSGLESLKETVIALAEEEG 415

Query: 416 LTAHKNAVTLRV 427
           L AH +A+  R 
Sbjct: 416 LQAHADAIRTRF 427


>UniRef50_Q58851 Histidinol dehydrogenase n=16 Tax=Euryarchaeota RepID=HISX_METJA
          Length = 429

 Score =  569 bits (1468), Expect = e-161,   Method: Composition-based stats.
 Identities = 176/433 (40%), Positives = 250/433 (57%), Gaps = 9/433 (2%)

Query: 1   MSFNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDK 60
           M    II       +++ + ++    +  E I  TV +IL +VK +GDEAL+ Y+ KFD 
Sbjct: 1   MVTGMIIKKIKELTKEEEEKIINRNKANFEEILPTVMEILKDVKEKGDEALKYYTKKFDG 60

Query: 61  TTVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQ-PGVRCQQ 119
             +   KV+ EEI  A   +  ++ +A+  A +NI  FH  Q     D+  +  G+   Q
Sbjct: 61  VEIEDFKVTDEEIEEAYNSVDYKVVEAIERAKENIYFFHKKQMEQIKDLNVENNGIILGQ 120

Query: 120 VTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPI----ADEILYAAQL 175
           V R +  VG Y+PGG A   STVLM   PA +AGC+++ + SPP          L A  +
Sbjct: 121 VVRAIEKVGCYVPGGRAFYPSTVLMTTIPAKVAGCEEIYITSPPTKDGKGNPATLIAGDI 180

Query: 176 CGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAG 235
            GV  ++ VGG QAI ALA+GTE++PKVD I GPGN +VT AK+ V   +   AID  AG
Sbjct: 181 VGVSAIYKVGGVQAIGALAYGTETIPKVDIIVGPGNIYVTTAKKMVYGEV---AIDFLAG 237

Query: 236 PSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRA 295
           PSEVL+IAD  A  +FVA D ++QAEH P++  ++ T +   A  +   +  ++ +  R 
Sbjct: 238 PSEVLIIADETANAEFVALDFIAQAEHDPNASCVITTTSEKKAEEIKNKIFEEIEKAERK 297

Query: 296 ETARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSP 355
           E   +AL  S +++  DL +C+E SN+Y PEHL I T+N  E+++ I  AGSVFLG++SP
Sbjct: 298 EIILKALENSAILI-GDLEECIEFSNKYAPEHLEILTKNPEEVLNKIKHAGSVFLGEYSP 356

Query: 356 ESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAER 415
              GDYASGTNHVLPT  +    S L +  F K++T Q+L KE    +A  + TLA AE 
Sbjct: 357 VPVGDYASGTNHVLPTSQFARMSSGLNVETFLKKITYQKLDKESLKNIADIVITLAEAEG 416

Query: 416 LTAHKNAVTLRVN 428
           L  H  AV  R+ 
Sbjct: 417 LFGHAEAVRRRLK 429


>UniRef50_Q722Y3 Histidinol dehydrogenase n=20 Tax=Firmicutes RepID=HISX_LISMF
          Length = 427

 Score =  568 bits (1465), Expect = e-160,   Method: Composition-based stats.
 Identities = 171/421 (40%), Positives = 246/421 (58%), Gaps = 7/421 (1%)

Query: 15  EQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIA 74
           E   +L +    + S  +   V  I++ VK  GD+AL ++++KFD   +T L+V A +I 
Sbjct: 10  ELLNELKIETDTNTSIQVETEVKTIIEKVKTAGDQALFDFTSKFDGVGLTELRVPAADIQ 69

Query: 75  AASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGG 134
           AAS ++      A+  A  NIE+FH+ QK        + GV   Q+ RP+ +VG+Y+PGG
Sbjct: 70  AASAKIEPAFLDALQQAKVNIESFHSKQKQHAFLDSEKDGVIRGQLIRPLETVGVYVPGG 129

Query: 135 SAPLFSTVLMLATPASIAGCKKVVLCSPP---PIADEILYAAQLCGVQDVFNVGGAQAIA 191
           +A   S+VLM   PA IAG K++V+ +PP    I   +L +AQL GV +++ VGGA  IA
Sbjct: 130 TAAYPSSVLMNVLPAKIAGVKRIVMITPPGENGINPYVLASAQLAGVDEIYQVGGAHGIA 189

Query: 192 ALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDF 251
           ALA GTES+PKVDKI GPGN +V  AKR+V   +D   IDM AGPSE++V+AD  A P F
Sbjct: 190 ALAHGTESIPKVDKIVGPGNIYVATAKREVFGLVD---IDMIAGPSEIVVLADENANPAF 246

Query: 252 VASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALN-ASRLIVT 310
           +A+DLLSQAEH   ++ IL+T +  +A      +++QL  LPR   A++++    ++I+ 
Sbjct: 247 IAADLLSQAEHDILARAILITTSKKIAEETQNEIDKQLENLPRKAIAQKSIETRGKIIIA 306

Query: 311 KDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLP 370
               +  +I N+  PEHL +Q  N    +  I +AGS+FLG ++ E  GDY +G NHVLP
Sbjct: 307 ATTQEMFDIMNEIAPEHLEVQLENPMNYLYQIKNAGSIFLGSYASEPLGDYFAGPNHVLP 366

Query: 371 TYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNAL 430
           T G     S LG+ DF KR      +KE  +     I  LA  E L AH  A+ +R    
Sbjct: 367 TSGTAKFFSPLGVEDFTKRSAFISYTKEALAKEKDAIVLLAKKEGLDAHAKAIQIRFEEE 426

Query: 431 K 431
            
Sbjct: 427 N 427


>UniRef50_A8RCE7 Putative uncharacterized protein n=1 Tax=Eubacterium dolichum DSM
           3991 RepID=A8RCE7_9FIRM
          Length = 427

 Score =  567 bits (1462), Expect = e-160,   Method: Composition-based stats.
 Identities = 177/429 (41%), Positives = 255/429 (59%), Gaps = 10/429 (2%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
               ++       Q +  +    +  + ++   V+ IL++V+  GDEA+  Y+ +FD   
Sbjct: 1   MLKQLNIEQID--QLQSYIEERRVVMNPALIGRVSAILEDVRMHGDEAVLRYTKQFDGME 58

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
           +  L+VS+EE+ A ++  + E +++M  A +NI  +H AQ      +E + G+   Q   
Sbjct: 59  LNKLRVSSEELNAQADLCTPEFRRSMQQAKENILFYHQAQISKGYRLEKEMGIYLGQRVL 118

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGV 178
           P+ SVG+Y+PGGSA   S+VLM A PA +AG K++V+ +PP     I   I  AA+L G+
Sbjct: 119 PLDSVGIYVPGGSAQYPSSVLMNALPARLAGVKRIVMLTPPSKEGSIHTNIALAAKLVGI 178

Query: 179 QDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSE 238
            +V+ VGGAQ IAALA+GT+S+ KVDKI GPGN +V  AK+ V   +D   IDM AGPSE
Sbjct: 179 DEVYKVGGAQGIAALAYGTQSIAKVDKIVGPGNVYVACAKKLVFGDVD---IDMIAGPSE 235

Query: 239 VLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETA 298
           +LVI D GA P ++A+DLLSQAEH P +  +LL  + +M   V + +++Q   LPR +  
Sbjct: 236 ILVIGDEGANPKWIAADLLSQAEHDPQASAVLLAVSQNMVDAVKQELQKQTRCLPRQKII 295

Query: 299 RQALNASRL-IVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPES 357
            ++L    L +V + L QCV+ISNQ  PEHL +      EL+  +  AGSVFLG  + ES
Sbjct: 296 HESLENYGLALVCESLQQCVDISNQIAPEHLELMVDKPEELLPLVRHAGSVFLGYATCES 355

Query: 358 AGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLT 417
            GDY  GTNHVLPT G     + LG+  F K+ +    S E   A   +I TLA AE+L 
Sbjct: 356 VGDYFGGTNHVLPTGGTARFFNPLGVDSFVKKSSYLHYSIEALQAYGDSIITLAEAEQLQ 415

Query: 418 AHKNAVTLR 426
           AH NAV +R
Sbjct: 416 AHANAVKVR 424


>UniRef50_Q9C5U8 Histidinol dehydrogenase, chloroplastic n=34 Tax=cellular organisms
           RepID=HISX_ARATH
          Length = 466

 Score =  566 bits (1459), Expect = e-160,   Method: Composition-based stats.
 Identities = 209/435 (48%), Positives = 274/435 (62%), Gaps = 8/435 (1%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
                 +  ++ Q   L  RP I  S SI  TVN I+D V++ GD A++EY+ +FDK  +
Sbjct: 32  MKSYRLSELSSSQVDSLKSRPRIDFS-SIFATVNPIIDAVRSNGDNAVKEYTERFDKVQL 90

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRP 123
             +     E+  +   L   +K+A  VA  NI  FH AQK     VE   GVRC++V+R 
Sbjct: 91  NKVVEDMSEL--SVPELDSNVKEAFDVAYDNIYAFHLAQKSTEKSVENMKGVRCKRVSRS 148

Query: 124 VASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQ 179
           + SVGLY+PGG+A L ST LMLA PA IAGCK VVL +PP     I  E+LY A+  GV 
Sbjct: 149 IGSVGLYVPGGTAVLPSTALMLAIPAQIAGCKTVVLATPPSKDGSICKEVLYCAKRAGVT 208

Query: 180 DVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEV 239
            +   GGAQAIAA+A+GT+S PKV+KIFGPGN +VT AK  +       +IDMPAGPSEV
Sbjct: 209 HILKAGGAQAIAAMAWGTDSCPKVEKIFGPGNQYVTAAKMILQNSEAMVSIDMPAGPSEV 268

Query: 240 LVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADM-ARRVAEAVERQLAELPRAETA 298
           LVIAD  A+P ++A+DLLSQAEHGPDSQV+L+     +    + E + +Q   LPR E A
Sbjct: 269 LVIADEHASPVYIAADLLSQAEHGPDSQVVLVVVGDSVDLNAIEEEIAKQCKSLPRGEFA 328

Query: 299 RQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESA 358
            +AL+ S  +  +D+ + +  SN Y PEHLII  ++A +    I +AGSVF+G W+PES 
Sbjct: 329 SKALSHSFTVFARDMIEAISFSNLYAPEHLIINVKDAEKWEGLIENAGSVFIGPWTPESV 388

Query: 359 GDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTA 418
           GDYASGTNHVLPTYGY    S + L  F K MTVQ L++EG   L   + T+A  E L A
Sbjct: 389 GDYASGTNHVLPTYGYARMYSGVSLDSFLKFMTVQSLTEEGLRNLGPYVATMAEIEGLDA 448

Query: 419 HKNAVTLRVNALKEQ 433
           HK AVTLR+  ++ +
Sbjct: 449 HKRAVTLRLKDIEAK 463


>UniRef50_Q02136 Histidinol dehydrogenase n=9 Tax=Bacteria RepID=HISX_LACLA
          Length = 431

 Score =  565 bits (1456), Expect = e-159,   Method: Composition-based stats.
 Identities = 164/435 (37%), Positives = 250/435 (57%), Gaps = 11/435 (2%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDK-- 60
               ID+     E+  +         S+ + +TV  I+ +++  GD AL  Y+ KFD   
Sbjct: 1   MLKQIDYQGKL-EEIAEKFQGRKTEVSKEVNKTVQQIVADIQKNGDTALFNYAKKFDGYD 59

Query: 61  TTVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQV 120
              + L V+  E  A  E++ ++  + +      IE FH  Q     ++  + GV   Q+
Sbjct: 60  VNTSNLLVTRMEREAGLEQIDEDYFRILRRTKSQIEEFHKHQLGNSWNIFKENGVIMGQI 119

Query: 121 TRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSP----PPIADEILYAAQLC 176
            RP+  V LY+PGG+A   STV+M A PA +AG K++++ +P      +   IL AA++C
Sbjct: 120 ARPLERVALYVPGGTAAYPSTVIMNAVPALLAGVKEIIMITPVKADGKVNPNILAAAEVC 179

Query: 177 GVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGP 236
           G++ ++ VGGAQ +AA+A+GTES+PKVDKI GPGN FV  AK+     +D   IDM AGP
Sbjct: 180 GIETIYKVGGAQGVAAVAYGTESIPKVDKIVGPGNIFVATAKKICYGVVD---IDMIAGP 236

Query: 237 SEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAE 296
           SEVLVIAD  A P ++A+DL++QAEH   +  IL+T +  + ++V E + RQ+  L R E
Sbjct: 237 SEVLVIADKTAKPKYIAADLMAQAEHDKLASAILVTTSEKLVQQVDEELNRQVQNLERRE 296

Query: 297 TARQAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSP 355
               ++ N    IV K++    ++SNQ  PEHL + T      +  I +AGS+F+G+++P
Sbjct: 297 IIESSIRNYGGAIVVKNIDDAFDVSNQLAPEHLEVLTSEPLTQLPKIKNAGSIFIGEYTP 356

Query: 356 ESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAER 415
           E  GDY SG+NHVLPT G     S LG+ +F K +T     KE  +     +ET A +E 
Sbjct: 357 EPLGDYMSGSNHVLPTGGTAKFYSGLGVYNFIKYLTYSYYPKEVLADFKEDVETFAKSEG 416

Query: 416 LTAHKNAVTLRVNAL 430
           LTAH N++++R + +
Sbjct: 417 LTAHANSISVRFDEM 431


>UniRef50_Q30TA4 Histidinol dehydrogenase n=16 Tax=Epsilonproteobacteria
           RepID=HISX_SULDN
          Length = 430

 Score =  564 bits (1455), Expect = e-159,   Method: Composition-based stats.
 Identities = 164/432 (37%), Positives = 249/432 (57%), Gaps = 11/432 (2%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
                  NS    + ++LL R  +  +  ++ TV  I+D +K+  ++AL+E+  KFDK T
Sbjct: 1   MIFTTSKNSSFKAEFKELLERGKMDIAH-VSATVGTIIDEIKSNKNQALKEHITKFDKWT 59

Query: 63  V---TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQ 119
                 LK+S E ++ A E L   LK A+ ++   I+ +H  QK      +   G    Q
Sbjct: 60  PVSDEDLKISTESMSRAYENLDKALKAALHLSYDRIKAYHEKQKPRSWFDDEPNGTILGQ 119

Query: 120 VTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLC 176
              PV S GLYIPGG A   S++LM   PA +AG + +V+C+P P     + +L A  LC
Sbjct: 120 RVTPVDSAGLYIPGGKAAYPSSLLMNVIPAQVAGVQNIVVCTPTPENEPNELLLAACHLC 179

Query: 177 GVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGP 236
           GV +V+ VGGA AIAA+A+GTE++PKVD I GPGN FV  AK+ V   ++   IDM AGP
Sbjct: 180 GVSEVYKVGGASAIAAMAYGTETIPKVDVITGPGNIFVATAKKMVFGDVN---IDMIAGP 236

Query: 237 SEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAE 296
           SE+ ++AD  A P  +A D+LSQAEH   +  IL+TP+  +A  +   +E  L  LPR +
Sbjct: 237 SEIGILADDSANPSHMAVDMLSQAEHDEMASSILITPSQKLADAIKAEIENWLKILPRQK 296

Query: 297 TARQALNA-SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSP 355
            AR+++     +IVT D+ + +++ N+  PEHL + T +  EL+  I  AG++FLG  +P
Sbjct: 297 IARESIEKRGAIIVTSDMQEAIDLMNEIAPEHLEVATLSPFELLPLIKHAGAIFLGHNTP 356

Query: 356 ESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAER 415
           E+ GDY +G NH LPT G     S LG+ +F K+ ++   S +  + +      +A  E 
Sbjct: 357 EAVGDYMAGPNHTLPTGGTAKFFSPLGVENFMKKTSIISFSAKAINEIGEECALIAKIEG 416

Query: 416 LTAHKNAVTLRV 427
           LTAH+ ++ +R+
Sbjct: 417 LTAHEQSIRVRL 428


>UniRef50_D1CF70 Histidinol dehydrogenase n=1 Tax=Thermobaculum terrenum ATCC
           BAA-798 RepID=D1CF70_THET1
          Length = 433

 Score =  564 bits (1454), Expect = e-159,   Method: Composition-based stats.
 Identities = 186/427 (43%), Positives = 273/427 (63%), Gaps = 9/427 (2%)

Query: 7   IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTAL 66
           I     + E++R+L  R   + S  +T  V  I+++V+ +GDE++REY+ +FD   + +L
Sbjct: 10  IRLADLSPEERRRLTHRSG-AISMDVTSVVRQIVEDVRQKGDESVREYTERFDGVKLDSL 68

Query: 67  KVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVAS 126
           +V   EI  A +R+   L +AM++A  NI  FH+AQ  P   VET PGV+  +V RP+  
Sbjct: 69  EVPRVEIETALDRIDQHLAEAMSIAASNIRAFHSAQIHPEPVVETSPGVKVWRVWRPIER 128

Query: 127 VGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQDVF 182
           VG+Y+PGG A   STVLM A PAS+AGC ++VLC+PP     + +  L AA L GV  VF
Sbjct: 129 VGVYVPGGGARYPSTVLMHAVPASVAGCSEIVLCTPPGPDGKVPEATLAAAALSGVTRVF 188

Query: 183 NVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVI 242
           ++GGAQAIAA+A+GT+++P V KIFGPGN +VT AK  V   +D   ID PAGPSE+++I
Sbjct: 189 SIGGAQAIAAMAYGTQTIPPVQKIFGPGNVYVTAAKMLVFGDVD---IDKPAGPSELVII 245

Query: 243 ADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL 302
           AD  A P   A+DL++Q+EH PD+  +L+T +  +A  V   + RQL +LP  +    + 
Sbjct: 246 ADDTADPRETAADLIAQSEHAPDNASVLVTTSESLAEAVLSELTRQLEDLPNRDRVISSF 305

Query: 303 -NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDY 361
            +   +++ +DLAQ V   N+Y PEHL I T + RE+++ I +AGS+FLG +SP  AGDY
Sbjct: 306 RSNGFILLVEDLAQAVGFVNEYAPEHLQIVTVSPREILEGINNAGSIFLGRYSPVPAGDY 365

Query: 362 ASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKN 421
           A G+NHVLPT G   T   L   +F K + VQEL++EG  ++++ +  +A AE L  H  
Sbjct: 366 AVGSNHVLPTSGSARTFGPLSTEEFGKWVQVQELTQEGLRSISNAVTAMARAENLEGHAR 425

Query: 422 AVTLRVN 428
           A+ +R +
Sbjct: 426 AIEVRFS 432


>UniRef50_Q8YSM8 Histidinol dehydrogenase 1 n=16 Tax=Bacteria RepID=HISX1_ANASP
          Length = 431

 Score =  561 bits (1447), Expect = e-158,   Method: Composition-based stats.
 Identities = 174/431 (40%), Positives = 256/431 (59%), Gaps = 7/431 (1%)

Query: 6   IIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA 65
           ++         + Q L+     A+  ++ TV DIL +VKARGD A++EY+++FD     +
Sbjct: 3   VLKTTDKEFSPRFQSLVSDRREATVDVSGTVRDILAHVKARGDAAVQEYTSRFDHYRPHS 62

Query: 66  LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVA 125
             +SA  IA  + + SDE+K A+ +A + I +FH  Q    +      GV+       ++
Sbjct: 63  HHLSAAFIAEQAAKCSDEVKAALELAAERISSFHQKQLPQDIGYTDTAGVKLGLNWVALS 122

Query: 126 SVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCGVQDVF 182
            VG+Y+PGG A   S+VLM A PA IAG +++V+  P P   I   +L AAQ+ GV +++
Sbjct: 123 QVGIYVPGGRASYPSSVLMNALPAKIAGVERIVMTVPMPHGEINPAVLAAAQVAGVTEIY 182

Query: 183 NVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVI 242
           ++GGAQA+ ALA+GTE++  VDKI GPGNA+V EAKRQV   +    ID  AGPSE+LV+
Sbjct: 183 SIGGAQAVGALAYGTETITPVDKIVGPGNAYVAEAKRQVFGTV---GIDSIAGPSEILVV 239

Query: 243 ADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL 302
           AD    P+++A DLLSQAEH P +Q IL+T +   A++V  AVE+ L  LP  + A  + 
Sbjct: 240 ADRQNNPEWIAWDLLSQAEHDPSAQSILITDSESFAQQVIAAVEQILTTLPSQKVASSSW 299

Query: 303 -NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDY 361
            N   +I+ +DLA+ + + NQ  PEH+ +   N + L   I  AGS+FLG ++PE+ GDY
Sbjct: 300 QNHGAVIIVRDLAESIPLLNQLAPEHVELCVDNPQLLASQIKCAGSLFLGRYTPEAIGDY 359

Query: 362 ASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKN 421
             G NHVLPT       S L + DF KR+T  E ++     +  +  TLA  E L AH  
Sbjct: 360 LGGPNHVLPTSRSARFASGLSVYDFLKRITYLECNQAALQKIGQSAVTLAETEGLPAHAG 419

Query: 422 AVTLRVNALKE 432
           +V +R+  LK+
Sbjct: 420 SVAVRLQGLKD 430


>UniRef50_C0GFZ9 Histidinol dehydrogenase n=1 Tax=Dethiobacter alkaliphilus AHT 1
           RepID=C0GFZ9_9FIRM
          Length = 432

 Score =  560 bits (1445), Expect = e-158,   Method: Composition-based stats.
 Identities = 183/431 (42%), Positives = 244/431 (56%), Gaps = 8/431 (1%)

Query: 9   WNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKV 68
                    R+   R         T+ V DIL  V  RGDEA+ EY+ KFD   +  L V
Sbjct: 2   LREFDGRTFRETFTRAGFDDYPEATQAVRDILAEVNQRGDEAVLEYTRKFDGVELETLLV 61

Query: 69  SAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVG 128
           S EE AAA E +  E++Q++  A +NI  FH  Q           GV   Q    V   G
Sbjct: 62  SEEEFAAAEEAVDPEVRQSLVEAAENIRDFHRRQVQNSWLEHQADGVALGQRVTAVEKAG 121

Query: 129 LYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQDVFNV 184
            Y+PGG A   S+VLM   PA +AG +KVVL +PP     I    L AA++ G   V+  
Sbjct: 122 AYVPGGGAAYPSSVLMTVIPARVAGVEKVVLVTPPQAGGEINPYTLVAAKIAGADAVYKC 181

Query: 185 GGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIAD 244
           GGAQA+AALA+GTE+VPKVDKI GPGN +VT AKR+VS  +    IDM AGPSEVLV+AD
Sbjct: 182 GGAQAVAALAYGTETVPKVDKIVGPGNLYVTLAKREVSGMV---GIDMLAGPSEVLVVAD 238

Query: 245 SGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-N 303
           + A  DFVA+DLLSQAEH   +    +T +A +A  + + ++RQ A+L R + AR++L  
Sbjct: 239 ASARADFVAADLLSQAEHDVMAASYCVTTSARLALDLQKELKRQCAQLERCDVARESLQQ 298

Query: 304 ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYAS 363
              L++   L + +EI N+  PEHL +Q     E +  + +AG+VF+G ++PE  GDY +
Sbjct: 299 QGALVIVDSLDEALEIVNELAPEHLELQLSEPWEALGKVKNAGAVFVGPYTPEPVGDYWA 358

Query: 364 GTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAV 423
           G NHVLPT G     S L + DF K+ +V   S +     A  IE LA  E LTAH  AV
Sbjct: 359 GPNHVLPTAGAGRFSSVLSVDDFVKKTSVIYYSPQALLKSAQKIEGLARVEGLTAHGQAV 418

Query: 424 TLRVNALKEQA 434
            +R   L+E+ 
Sbjct: 419 KIRREYLEEKG 429


>UniRef50_Q46J19 Histidinol dehydrogenase n=60 Tax=Bacteria RepID=HISX_PROMT
          Length = 449

 Score =  559 bits (1441), Expect = e-158,   Method: Composition-based stats.
 Identities = 164/433 (37%), Positives = 252/433 (58%), Gaps = 10/433 (2%)

Query: 4   NTIIDWNSCTAE--QQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKT 61
            TI   NS      + R++  R + +  +   + V+DIL NV+ RGDEAL EY+++FD  
Sbjct: 18  LTIKTANSIDQAQFELRKITERTSGTVQDEAIKVVDDILKNVRERGDEALTEYTSRFDGF 77

Query: 62  TVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVT 121
                +VS++ I  A E    EL+ ++ +A K IE FH+ Q    +      G    +  
Sbjct: 78  LTEKFQVSSDLILKAWEETPRELQDSLLLAKKRIEKFHSLQVPKNITYTGPNGETLGRRW 137

Query: 122 RPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCG 177
            PV   G+Y+PGG A   STVLM A PA +AG  ++++ SP      I   +L AA + G
Sbjct: 138 SPVEKAGIYVPGGRAAYPSTVLMNAIPAYVAGVNQIIMVSPANSQGEINQTVLAAAHITG 197

Query: 178 VQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPS 237
           +  +F +GGAQAI ALA GTES+PKVD I GPGN +VT AK++V  ++    ID  AGPS
Sbjct: 198 INKIFRLGGAQAICALASGTESIPKVDVITGPGNIYVTLAKKKVYGKV---GIDSLAGPS 254

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAET 297
           E+L+IAD  A  + VASD+L+Q+EH P +  IL+T    +A ++   + RQL   PR + 
Sbjct: 255 EILIIADQSAKLEHVASDMLAQSEHDPLASAILITTNTKLAEKLPAEINRQLINHPRLKI 314

Query: 298 ARQAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPE 356
            ++++ N   +++  DL  C ++S+ + PEHL +   + ++L +SI +AG++F+G WSPE
Sbjct: 315 CQESISNWGLIVLCDDLETCAQLSDTFAPEHLELLVEDPKKLSESINNAGAIFMGPWSPE 374

Query: 357 SAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERL 416
           + GDY  G NH LPT G      +LG+  F K  ++ + SKE F+   + +  LA +E L
Sbjct: 375 AIGDYLGGPNHTLPTSGTARFAGALGVETFMKNTSLIDFSKEAFNENKNAVVQLANSEGL 434

Query: 417 TAHKNAVTLRVNA 429
            +H  ++ +R + 
Sbjct: 435 HSHAESIRIRDSK 447


>UniRef50_C6Y3G2 Histidinol dehydrogenase n=6 Tax=cellular organisms
           RepID=C6Y3G2_PEDHD
          Length = 430

 Score =  559 bits (1441), Expect = e-158,   Method: Composition-based stats.
 Identities = 198/432 (45%), Positives = 277/432 (64%), Gaps = 6/432 (1%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
             I  +   T ++  ++ +R  +    +I   V  I++ VK  GD+AL +Y+  FD+  +
Sbjct: 1   MKIYSYKDLTKQEVEEICLR-QLEDDVNIQERVKSIVERVKMEGDKALFDYALSFDQIRL 59

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRP 123
             L +  +EI   +  +  E K A+  A +NI+TFH +Q L    VET PGV C + TR 
Sbjct: 60  EELFIDQQEIMTIAATIPAEAKAAIDTAYQNIKTFHASQLLQEDKVETMPGVTCWRETRA 119

Query: 124 VASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIAD----EILYAAQLCGVQ 179
           +  VGLYIPGG+A L ST LML  PA +AGCK++V+CSPP         + Y A L G++
Sbjct: 120 IERVGLYIPGGTAVLPSTFLMLGIPAVLAGCKEIVVCSPPQKDGKTNCYLAYVATLLGIE 179

Query: 180 DVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEV 239
            ++ VGGAQA+AA+A+GT SVPKVDK+FGPGN +VT+AK+ +       AIDMPAGPSEV
Sbjct: 180 RIYLVGGAQAVAAMAYGTASVPKVDKVFGPGNRYVTQAKQLIQGNT-MTAIDMPAGPSEV 238

Query: 240 LVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETAR 299
           LV+AD  A P ++ASDLL+QAEHG DSQ IL+  ++ +     E +  QL  LPRA  A 
Sbjct: 239 LVLADETAIPSYIASDLLAQAEHGIDSQTILVATSSKIIDETMEQLALQLQVLPRAAFAT 298

Query: 300 QALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAG 359
           +A+  S  ++  DL + ++ SN Y PEHLI+ T N   L+  I++AGSVFLG+ +PESAG
Sbjct: 299 KAIENSYSVLVNDLEEGMKFSNVYAPEHLILATDNCERLIPLISNAGSVFLGNLTPESAG 358

Query: 360 DYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAH 419
           DYASGTNH LPT GY    S + +  F K++T Q ++ +G   + +T+E LAAAE L AH
Sbjct: 359 DYASGTNHTLPTSGYARAYSGVSMDSFMKKITFQHITTQGLRHIGNTVEVLAAAEGLDAH 418

Query: 420 KNAVTLRVNALK 431
           KNAV++R+ +L 
Sbjct: 419 KNAVSIRLKSLD 430


>UniRef50_Q6FEC8 Histidinol dehydrogenase n=50 Tax=Bacteria RepID=HISX_ACIAD
          Length = 430

 Score =  557 bits (1435), Expect = e-157,   Method: Composition-based stats.
 Identities = 162/433 (37%), Positives = 246/433 (56%), Gaps = 10/433 (2%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKT- 61
               +     + +Q    L+         + +TV+ I+ +V+  GDE + + + +FD+  
Sbjct: 1   MMRRLSTQDQSFKQVFADLLAFETVNDPELLKTVDQIIADVRQYGDEHVLKLTQQFDRHP 60

Query: 62  --TVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQ 119
               + L+++ E++  A E L+ E+++A+ +A + I +FH AQK          G    Q
Sbjct: 61  AHQFSDLELTQEQLKTAFEALTAEIREALELAAERIRSFHQAQKQEGWSYVDALGNTLGQ 120

Query: 120 VTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLC 176
              P+  VG+Y+PGG A   S+VLM A PA +AG  ++++  P P   +   +L AA L 
Sbjct: 121 KVTPLDRVGIYVPGGLASYPSSVLMNAIPAHVAGVPEIIMVVPAPNGELNSLVLAAAYLA 180

Query: 177 GVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGP 236
           GV  +F +GGAQA+AALA+GT+++P VDKI GPGN FV  AKR V  ++    IDM AGP
Sbjct: 181 GVSRIFTIGGAQAVAALAYGTQTIPAVDKITGPGNRFVAAAKRAVFGQV---GIDMIAGP 237

Query: 237 SEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAE 296
           SE+LV A+      ++A DLLSQAEH   +Q I +TP   +   VA+A+E  LA LP+A+
Sbjct: 238 SEILVYAEGQNNAKWLAMDLLSQAEHDTVAQAIFITPDEALLDEVAQAIEEHLAALPKAD 297

Query: 297 TARQALNA-SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSP 355
            AR ++     L++ KD  + +E+ NQ  PEHL +    +  +   I  AG++F+G ++P
Sbjct: 298 IARTSIANRGALVLVKDRDEAIELINQVAPEHLELCLDESEAMSQKIRHAGAIFMGRYTP 357

Query: 356 ESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAER 415
           E+ GDY +G NHVLPT G     S LG+ DFQKR ++   S+EG  +LA   + LA  E 
Sbjct: 358 EAIGDYCAGPNHVLPTSGTARFSSPLGVYDFQKRSSLIMCSQEGVKSLAKAADVLAQQEN 417

Query: 416 LTAHKNAVTLRVN 428
           L AH  +   R  
Sbjct: 418 LDAHARSARYRYQ 430


>UniRef50_B0TY46 Histidinol dehydrogenase n=2 Tax=Francisella philomiragia
           RepID=B0TY46_FRAP2
          Length = 432

 Score =  557 bits (1435), Expect = e-157,   Method: Composition-based stats.
 Identities = 191/432 (44%), Positives = 276/432 (63%), Gaps = 4/432 (0%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              I +W   +  +Q +LL RP  +   S+   V +IL+ VK  GD+AL E++++FD   
Sbjct: 1   MIEIYNWQELSLVKQAELLSRPVSANKASLVAGVRNILNAVKQNGDKALLEFTSRFDGVD 60

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
           +  ++VSA EI  A   +S +  + +  ++  I  +H   K      +T  GV C+++ +
Sbjct: 61  LDNIEVSAHEIKEAYSLVSQDDIELVKNSIARISNYHEVMKPKTTVCDTNDGVVCKKIYK 120

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSP----PPIADEILYAAQLCGV 178
           P+  VGLY+PGGSAPL ST++MLA PA IAGCK++ + +P      I   IL AA +C V
Sbjct: 121 PIEKVGLYVPGGSAPLVSTLIMLAAPAQIAGCKEIYVTTPCDKEGNIHPLILIAADICKV 180

Query: 179 QDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSE 238
             ++ +GGAQAIAALA+GTE+V KV+KI+GPGN++VTEAK+QVS    GAAID+PAGPSE
Sbjct: 181 SKIYKLGGAQAIAALAYGTETVTKVNKIYGPGNSWVTEAKQQVSNDSQGAAIDLPAGPSE 240

Query: 239 VLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETA 298
           VLV+AD  A   FVA+DLL+QAEHG DSQ +L+T +  +A +V + V +Q +   R    
Sbjct: 241 VLVVADEVADARFVAADLLAQAEHGTDSQALLITTSQILADKVRDEVSKQTSTAQRKAII 300

Query: 299 RQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESA 358
            +AL  S +IV   L+Q + I+N+Y  EHLI+    A   +DSI +AG+VF+G W+ E+ 
Sbjct: 301 EKALENSAIIVVDTLSQAINIANEYASEHLILNIETADNYIDSIENAGAVFVGPWAAEAL 360

Query: 359 GDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTA 418
           GDY +G+NHVLPTYGY    S L   DF K +++Q +SK+G   +      LA  E L A
Sbjct: 361 GDYITGSNHVLPTYGYAKAYSGLATIDFMKAISIQNVSKQGIKNIGQIAMRLADIEGLKA 420

Query: 419 HKNAVTLRVNAL 430
           H+NA+ +R+ +L
Sbjct: 421 HENAIAIRLESL 432


>UniRef50_Q4ZNV9 Histidinol dehydrogenase n=116 Tax=Bacteria RepID=HISX_PSEU2
          Length = 448

 Score =  554 bits (1429), Expect = e-156,   Method: Composition-based stats.
 Identities = 165/428 (38%), Positives = 240/428 (56%), Gaps = 10/428 (2%)

Query: 7   IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDK---TTV 63
           +D       +    L+     + +S+ + V DI+  V+ RGD AL E++ KFD     ++
Sbjct: 10  LDAADPDFARHLDHLLSWESVSDDSVNQRVLDIIKAVRERGDAALVEFTQKFDGLQVASM 69

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRP 123
             L +  E +  A  R++   ++A+  A + + ++H  QK          G    Q   P
Sbjct: 70  ADLILPRERLELALTRITPGQREALEKAAERVRSYHEKQKQDSWSYTEADGTVLGQKVTP 129

Query: 124 VASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCGVQD 180
           +   GLY+PGG A   S+VLM A PA +AG  +VV+  P P   I + +L AA + GV  
Sbjct: 130 LDRAGLYVPGGKASYPSSVLMNAIPAKVAGVTEVVMVVPTPRGEINELVLAAACIAGVDR 189

Query: 181 VFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVL 240
           VF +GGAQA+AALA+GTESVPKVDK+ GPGN +V  AKR V  ++    IDM AGPSE+L
Sbjct: 190 VFTIGGAQAVAALAYGTESVPKVDKVVGPGNIYVATAKRHVFGQV---GIDMIAGPSEIL 246

Query: 241 VIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQ 300
           V+ D    PD++A DL SQAEH  D+Q IL++P A+   +VA ++ R L  + RA     
Sbjct: 247 VVCDGQTDPDWIAMDLFSQAEHDEDAQAILVSPDAEFLDKVAASITRLLPTMERAAIVET 306

Query: 301 ALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAG 359
           ++N    LI   D+AQ +E++N+  PEHL +   +    +  I  AG++F+G  + E+ G
Sbjct: 307 SINGRGALIKVADMAQAIEVANRIAPEHLELSVADPEAWLPQIRHAGAIFMGRHTSEALG 366

Query: 360 DYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAH 419
           DY +G NHVLPT G     S LG+ DFQKR ++   S +G S L  T   LA  E L+ H
Sbjct: 367 DYCAGPNHVLPTSGTARFSSPLGVYDFQKRSSIIYCSPQGASELGKTASVLARGESLSGH 426

Query: 420 KNAVTLRV 427
             +   R+
Sbjct: 427 ARSAEYRI 434


>UniRef50_P59399 Histidinol dehydrogenase n=14 Tax=Bacteria RepID=HISX_LACPL
          Length = 428

 Score =  553 bits (1426), Expect = e-156,   Method: Composition-based stats.
 Identities = 175/429 (40%), Positives = 250/429 (58%), Gaps = 9/429 (2%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
             II+     A  +R +  +        +   V +I+ NV   GD A+++Y  +FDK T+
Sbjct: 1   MKIIN--EDLASLKRLVQTKTQQLTDLKVESAVREIIANVIKNGDAAVKDYETQFDKVTL 58

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRP 123
           T  K+S   I  A   L  ++K A+ +A +NI +FH  +K        QPGV   Q   P
Sbjct: 59  TDFKLSQTVIDDAYNNLDPQVKDALLLAKRNITSFHEKEKATGFIDAEQPGVLRGQKLMP 118

Query: 124 VASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP---PIADEILYAAQLCGVQD 180
           +  VGLY+PGG+A   ST+LM A PA IAG  +V++ +PP    I   +L AA++ GV  
Sbjct: 119 LNRVGLYVPGGTAAYPSTLLMSALPAKIAGVNEVIMVTPPQVDGINPAVLAAAKIAGVDA 178

Query: 181 VFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVL 240
           ++ VGGAQAIAALA+GTES+P VDKI GPGN FV  AK+QV  ++   AIDM AGPSE+ 
Sbjct: 179 IYQVGGAQAIAALAYGTESIPAVDKIIGPGNIFVATAKKQVFGQV---AIDMVAGPSEIG 235

Query: 241 VIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQ 300
           ++AD  A P  +A+DLLSQAEH   ++ IL+T +AD+A+ V++ V  QL  LPR   A  
Sbjct: 236 ILADDSADPRQLAADLLSQAEHDRRARPILITDSADLAQAVSDNVTSQLKVLPREAIATD 295

Query: 301 AL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAG 359
           A+     + V   + +  ++ N   PEHL +Q +N  + ++ I +AGSVFLG ++ E  G
Sbjct: 296 AVNEKGFIAVVAKIEEMFDLMNTVAPEHLEVQLKNPTQYLNLIKNAGSVFLGRYASEPLG 355

Query: 360 DYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAH 419
           DY +G NH+LPT G     S LG+ DF KR +  + +K+  +  A  I TLA  E L  H
Sbjct: 356 DYVAGPNHILPTSGTARFSSPLGVYDFVKRTSFIQYTKDALAKEAPAITTLARVEGLEGH 415

Query: 420 KNAVTLRVN 428
             A+  R +
Sbjct: 416 ARAIESRFD 424


>UniRef50_D0RRH1 Histidinol dehydrogenase n=1 Tax=alpha proteobacterium HIMB114
           RepID=D0RRH1_9RICK
          Length = 429

 Score =  552 bits (1424), Expect = e-156,   Method: Composition-based stats.
 Identities = 159/431 (36%), Positives = 247/431 (57%), Gaps = 9/431 (2%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT- 62
             I++  +   ++   L++      S +  + V  I+ ++K  GD AL +Y+ +FDK   
Sbjct: 1   MKILNTKNKLFKKNFDLVLSSKRIQSNNSQKIVKKIISDIKKNGDLALIKYTKRFDKVNF 60

Query: 63  -VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVT 121
             + +K+  + I+   ++L   +K+++ +A   I  FH  Q       + + G +     
Sbjct: 61  GPSKIKLDDKLISKKIKKLDINIKKSIDLAFNRITKFHKKQVHKGFKFKDKLGNQLGYKI 120

Query: 122 RPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCGV 178
            P+  VG+Y+PGG+A   ST+LM + PA +AG K +    P P   I   +LYAA+ C +
Sbjct: 121 LPLDKVGVYVPGGTASYPSTLLMNSIPAMVAGVKNIYCVMPTPKDEINAGVLYAAKKCKI 180

Query: 179 QDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSE 238
           + +F +GGAQA+AAL +GT++VPKVDKI GPGN FV  AK++V   +    IDM AGPSE
Sbjct: 181 KSIFRIGGAQAVAALTYGTKNVPKVDKIVGPGNIFVATAKKEVFGTV---GIDMVAGPSE 237

Query: 239 VLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETA 298
           + VIAD     D+ A DLLSQAEH   SQ ILLT +   A++V+  V++ L  LPR + A
Sbjct: 238 ITVIADDRNRADWTAVDLLSQAEHDVLSQSILLTTSEKFAKQVSLEVKKILKTLPRKKIA 297

Query: 299 RQALNA-SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPES 357
            +++     ++V K+  + V+ +N   PEHL I+ + + +L   I +AGS+FLG++SPE+
Sbjct: 298 SKSIKNYGCIVVCKNKKELVDYANIIAPEHLEIKIKGSEKLEKQIKNAGSIFLGEFSPEA 357

Query: 358 AGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLT 417
            GDY +G NHVLPT G     S L + DF KR ++ + +K G   +      LA  E L 
Sbjct: 358 IGDYLAGPNHVLPTSGSARFASGLSVNDFLKRTSLIKCTKRGIEKIGQMAINLANYEGLH 417

Query: 418 AHKNAVTLRVN 428
           AH  +V+ R+ 
Sbjct: 418 AHALSVSKRIK 428


>UniRef50_D0JBA3 Histidinol dehydrogenase n=2 Tax=Blattabacterium RepID=D0JBA3_BLASB
          Length = 435

 Score =  552 bits (1424), Expect = e-156,   Method: Composition-based stats.
 Identities = 185/430 (43%), Positives = 270/430 (62%), Gaps = 7/430 (1%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
           N I  +   T +  + +L R +   S  +T  V  I++NVK  GD A++ Y+ K+D   +
Sbjct: 3   NMIQVYIHPTYKTCQSILNRSSEKISH-LTDLVLSIINNVKNNGDTAVKTYTRKYDHVDI 61

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRP 123
             ++V+ E+   A+ ++S  L++++ +A KNIE FH  Q      +E   GV C + + P
Sbjct: 62  KHIQVTEEDFQKANMKVSSHLRKSIEIAYKNIECFHKKQIHEESKIEVSTGVFCWRKSVP 121

Query: 124 VASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQ 179
           +  VG YIPGGSAPL STVLML  P  +AGCK +VLCSPP     I   +LY A+  G+ 
Sbjct: 122 IEKVGFYIPGGSAPLLSTVLMLGVPGKLAGCKNIVLCSPPNKNGEIHPSVLYTAKYVGIN 181

Query: 180 DVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEV 239
            ++ VGG QAIAA+A+GTES+P V KIFGPGN +VT AK+ VSQ+    +IDMPAGPSEV
Sbjct: 182 QIYKVGGVQAIAAMAYGTESIPSVYKIFGPGNCYVTIAKQIVSQK-GIVSIDMPAGPSEV 240

Query: 240 LVIADSGATPDFVASDLLSQAEHGPDSQVILLT-PAADMARRVAEAVERQLAELPRAETA 298
           +++AD  A P +VASDLLSQ+EH P+S ++L+T        +V E +++Q   L + +  
Sbjct: 241 VIMADDEANPKYVASDLLSQSEHDPESYILLVTINNKSWIEKVKEELKKQFYHLSKKKIL 300

Query: 299 RQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESA 358
            +    S+++V   L +C+   NQ  PEHLII   N     + + +AGSVFLG++SP S 
Sbjct: 301 LKIFRKSKIVVFSSLEECMNFINQVAPEHLIINCNNVSYWSEKVINAGSVFLGNYSPVSI 360

Query: 359 GDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTA 418
           GDYASGTNHVLPTYGY  + S + +  F K++T Q++SK+G   L+  +  L++ E L A
Sbjct: 361 GDYASGTNHVLPTYGYAKSYSGVSVDSFVKKITFQKISKKGLQNLSECVNVLSSEEGLIA 420

Query: 419 HKNAVTLRVN 428
           HK ++ +R+ 
Sbjct: 421 HKKSIDIRLK 430


>UniRef50_A9NV24 Histidinol dehydrogenase n=2 Tax=Spermatophyta RepID=A9NV24_PICSI
          Length = 491

 Score =  552 bits (1423), Expect = e-156,   Method: Composition-based stats.
 Identities = 197/443 (44%), Positives = 265/443 (59%), Gaps = 15/443 (3%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
                     + Q   L  RP I  S S+   V  I+++V+ RGD A+ +Y+ KFD   +
Sbjct: 50  MKTYRLADLHSTQIDHLKARPRIDFS-SMFGVVGPIIEDVRKRGDVAVIDYTTKFDGVNL 108

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQP-------GVR 116
             +     ++     +L   ++ A  VA  NI  FH AQ+ P   VE          GV 
Sbjct: 109 DKVVECVADLPD--PKLDSAVQAAFDVAYDNIRAFHAAQRNPERVVENMKVGSVLGRGVM 166

Query: 117 CQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYA 172
           C++V R + SVGLY+PGG+A L ST LMLA PA +AGC+ ++L SPP     I  E+LY 
Sbjct: 167 CKRVARSIDSVGLYVPGGTAVLPSTALMLAVPAQLAGCRIIILASPPRPDGSICKEVLYC 226

Query: 173 AQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDM 232
           A+  GV  +   GGAQAI+A+A+GT S PKV+KI GPGN +VT AK  +       +IDM
Sbjct: 227 AKKAGVTHILKAGGAQAISAMAWGTTSCPKVEKILGPGNQYVTAAKMILQNSEAMISIDM 286

Query: 233 PAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADM-ARRVAEAVERQLAE 291
           PAGPSEVLVIAD  A P ++A+DLLSQAEHGPDSQV+L+     +    +   +E+Q   
Sbjct: 287 PAGPSEVLVIADKHANPVYIAADLLSQAEHGPDSQVVLVLVGEGVNLDEIEMELEKQCKS 346

Query: 292 LPRAETARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLG 351
           LPR + A +AL  S  ++ ++ A+ +  SN Y PEHLII   +A + VD I +AGSVFLG
Sbjct: 347 LPRGQFAAKALTHSFTVLARNKAEAISFSNLYAPEHLIINVEDADQWVDYIENAGSVFLG 406

Query: 352 DWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLA 411
            WSPES GDYASGTNHVLPTYGY      + L  F K +TVQ L++EG  +L   +  +A
Sbjct: 407 RWSPESIGDYASGTNHVLPTYGYARMYGGVSLDSFMKYITVQSLTEEGLKSLGPHVVKMA 466

Query: 412 AAERLTAHKNAVTLRVNALKEQA 434
             E L AHK AVTLR+  ++ ++
Sbjct: 467 EVEGLEAHKRAVTLRLQDIETRS 489


>UniRef50_B9D1F9 Histidinol dehydrogenase n=2 Tax=Campylobacter RepID=B9D1F9_WOLRE
          Length = 431

 Score =  550 bits (1418), Expect = e-155,   Method: Composition-based stats.
 Identities = 159/434 (36%), Positives = 246/434 (56%), Gaps = 9/434 (2%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
              +  ++   +     L+  +     ++T  V+ IL++V+ARGDEAL E   KFD+   
Sbjct: 1   MKFLLTSNENFKDYFAALVNRSNGDMSAVTPAVSQILEDVRARGDEALFEQIEKFDRWKP 60

Query: 64  T--ALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVT 121
              +LK+  EE+  A + +   L+ A+ +A + I+++H            + GV      
Sbjct: 61  DTNSLKIGTEEMQKAYDGIDSCLRNALNLAFERIKSYHEKSLPKTWMEHDEHGVLLGAKY 120

Query: 122 RPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSP---PPIADEILYAAQLCGV 178
            P+   GLYIPGG A   S++LM A PA +AG  ++ +C+P     +   +L A  +CG+
Sbjct: 121 TPLDRAGLYIPGGKAAYPSSLLMNAVPALVAGVGEIAVCTPAVGGKVNTLLLAAMHICGI 180

Query: 179 QDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSE 238
           ++ + VGGA A+AA+A+GT+++ K D I GPGN +V  AK+ V   ++   IDM AGPSE
Sbjct: 181 KEAYKVGGASAVAAMAYGTQTIKKTDVITGPGNIYVATAKKLVYGEVN---IDMIAGPSE 237

Query: 239 VLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETA 298
           + VIAD  A P  +A DLLSQAEH   +  +L+TP       V   +  ++  L R   A
Sbjct: 238 ICVIADESADPRHIAVDLLSQAEHDEMASAVLITPNQAFGAAVQRHINEEIKTLARQPIA 297

Query: 299 RQALNA-SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPES 357
           + +++    +IV  DL +CV ++N+  PEHL I T +A EL   I  AG++F+G ++PE+
Sbjct: 298 QASIDKKGAIIVASDLGECVRLANELAPEHLEIATNDAMELARQIRHAGAIFIGHFTPEA 357

Query: 358 AGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLT 417
            GDY +G NH LPT G     S LG+ +F KR ++  L+ +G S LA+    LA AE L 
Sbjct: 358 MGDYLAGPNHTLPTGGSARFYSPLGVENFMKRTSLISLNAKGISELANACMELAEAEGLG 417

Query: 418 AHKNAVTLRVNALK 431
           AH+ +V +R+ ALK
Sbjct: 418 AHRRSVVVRLEALK 431


>UniRef50_P00815 Histidinol dehydrogenase n=17 Tax=cellular organisms
           RepID=HIS2_YEAST
          Length = 799

 Score =  550 bits (1417), Expect = e-155,   Method: Composition-based stats.
 Identities = 194/431 (45%), Positives = 269/431 (62%), Gaps = 10/431 (2%)

Query: 10  NSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVS 69
            +      ++ L RP    SE I   VN I++NV+ +G+ AL EY+ KFD   ++   ++
Sbjct: 363 KASDKVGVQKALSRPIQKTSE-IMHLVNPIIENVRDKGNSALLEYTEKFDGVKLSNPVLN 421

Query: 70  AEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPV-DVETQPGVRCQQVTRPVASVG 128
           A       E L++E+K+A+ ++++N+  FH AQ      +VETQPGV C +  RP+  VG
Sbjct: 422 APFPEEYFEGLTEEMKEALDLSIENVRKFHAAQLPTETLEVETQPGVLCSRFPRPIEKVG 481

Query: 129 LYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP-----PIADEILYAAQLCGVQDVFN 183
           LYIPGG+A L ST LML  PA +A CK++V  SPP      ++ E++Y A+  G   +  
Sbjct: 482 LYIPGGTAILPSTALMLGVPAQVAQCKEIVFASPPRKSDGKVSPEVVYVAEKVGASKIVL 541

Query: 184 VGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDG-AAIDMPAGPSEVLVI 242
            GGAQA+AA+A+GTE++PKVDKI GPGN FVT AK  V        +IDMPAGPSEVLVI
Sbjct: 542 AGGAQAVAAMAYGTETIPKVDKILGPGNQFVTAAKMYVQNDTQALCSIDMPAGPSEVLVI 601

Query: 243 ADSGATPDFVASDLLSQAEHGPDSQVILLTP--AADMARRVAEAVERQLAELPRAETARQ 300
           AD  A  DFVASDLLSQAEHG DSQVIL+    +    + + +AV  Q  +LPR +  R+
Sbjct: 602 ADEDADVDFVASDLLSQAEHGIDSQVILVGVNLSEKKIQEIQDAVHNQALQLPRVDIVRK 661

Query: 301 ALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGD 360
            +  S +++     + +E+SNQY PEHLI+Q  NA + V  + +AGSVF+G ++PES GD
Sbjct: 662 CIAHSTIVLCDGYEEALEMSNQYAPEHLILQIANANDYVKLVDNAGSVFVGAYTPESCGD 721

Query: 361 YASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHK 420
           Y+SGTNH LPTYGY    S    A FQK +T Q ++ EG   +   +  +A  E L  H+
Sbjct: 722 YSSGTNHTLPTYGYARQYSGANTATFQKFITAQNITPEGLENIGRAVMCVAKKEGLDGHR 781

Query: 421 NAVTLRVNALK 431
           NAV +R++ L 
Sbjct: 782 NAVKIRMSKLG 792


>UniRef50_Q2NHT1 HisD n=1 Tax=Methanosphaera stadtmanae DSM 3091 RepID=Q2NHT1_METST
          Length = 407

 Score =  548 bits (1413), Expect = e-154,   Method: Composition-based stats.
 Identities = 164/409 (40%), Positives = 252/409 (61%), Gaps = 8/409 (1%)

Query: 28  ASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQA 87
            S  + + V +I+ NV    D+AL +Y+ KFDK  ++  KV  E I  + E +S +L++A
Sbjct: 2   NSSDVIQPVQEIIANVCENKDKALHDYTLKFDKADISDFKVPVETIKQSVENISPKLRKA 61

Query: 88  MAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLAT 147
           +  A +NI  FH AQ      +  + GV+  Q+ RP++ VG YIPGG A   S++LM   
Sbjct: 62  LEDAAENISKFHKAQIPSDWTMTVKDGVKAGQIIRPLSRVGCYIPGGRAAYPSSILMTVI 121

Query: 148 PASIAGCKKVVLCSPPP----IADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKV 203
           PA IAG ++++ C+PP     ++DEIL AA + GV D++ VGGAQAIAA+A+ T+++P V
Sbjct: 122 PAKIAGVEEIICCTPPDKDGCVSDEILAAAYIAGVTDIYMVGGAQAIAAMAYSTQTIPSV 181

Query: 204 DKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHG 263
           DKI GPGN FV  AK+ V   +D   I+ PAGPSE+L + D  A P+++A++LL+QAEH 
Sbjct: 182 DKIVGPGNIFVATAKKLVYGDVD---IEFPAGPSEMLALVDETANPEYIATELLAQAEHD 238

Query: 264 PDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVEISNQ 322
           P++  IL++ + ++A++  E V   L    R++   ++L     ++V   +   ++ +N 
Sbjct: 239 PNAATILVSTSKEVAQKTVEHVMEYLKTQKRSDIIEESLSKYGHVLVASSMEDAIDFTNA 298

Query: 323 YGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLG 382
           Y PEHL+I T++  + ++SI +AGS+FLG+ +P + GDY SGTNHVLPT G     S L 
Sbjct: 299 YAPEHLVIVTKDHYKTLESINNAGSIFLGNLTPVAGGDYGSGTNHVLPTSGGARMYSGLS 358

Query: 383 LADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNALK 431
              F K+ T+QELS EG   +   +  LA AE L AH  ++  R   ++
Sbjct: 359 AESFLKKPTIQELSPEGVKNIKDMVINLAEAEGLYAHALSIKKRAEDME 407


>UniRef50_C9LTV1 Histidinol dehydrogenase n=1 Tax=Selenomonas sputigena ATCC 35185
           RepID=C9LTV1_9FIRM
          Length = 449

 Score =  547 bits (1411), Expect = e-154,   Method: Composition-based stats.
 Identities = 164/452 (36%), Positives = 246/452 (54%), Gaps = 26/452 (5%)

Query: 4   NTIIDWNSCTAEQQRQLLMRP---AISASESITRTVNDI--------------LDNVKAR 46
             I+       ++ R+LL++P    +  +  I      I              +++V+  
Sbjct: 1   MKIVSAKELGKDKIRKLLVKPPFDEVQLNPKIREANRKIFGADLTAAEVAVRIVEDVRRH 60

Query: 47  GDEALREYSAKFDKTT--VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKL 104
           GDEA+ +Y+   D T       +VS EE A A +     +  ++  A  N+ ++H  QK 
Sbjct: 61  GDEAVIKYTKLIDGTDFSPEDFQVSEEEFAEAEKNADPAIVASLQRAAHNVRSYHEEQKA 120

Query: 105 PPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP 164
                  + G    Q   P+   G+Y+PGG+A   S+VLM A PA++AG  ++++  PP 
Sbjct: 121 NSWLTYREKGSILGQSLIPLDRAGIYVPGGTAAYPSSVLMNAVPAAVAGVGEIIMMVPPK 180

Query: 165 ---IADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQV 221
              I   +L AA++ GV  V+ +GGAQAIAA+A+GT ++P+VDKI GPGN FVT AK+ V
Sbjct: 181 NGKINPYVLLAAKIAGVSKVYKIGGAQAIAAMAYGTATIPRVDKITGPGNIFVTLAKKAV 240

Query: 222 SQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRV 281
               D   IDM AGPSE+L++AD  A P + A+D+LSQAEH   +  IL+T +A +A  V
Sbjct: 241 YGHCD---IDMLAGPSEILIVADETADPAYTAADMLSQAEHDTLASSILITTSAKLAHEV 297

Query: 282 AEAVERQLAELPRAETARQALNA-SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVD 340
              +E QL  LPR   AR ++     +++  D+ + +E +N   PEH+ + T+   EL+ 
Sbjct: 298 EALLEEQLKGLPRENIARASIENNGLIVIADDIMEALEYANISAPEHMELLTKQPFELLP 357

Query: 341 SITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGF 400
            +  AG+VFLG +SPE  GDY +G NHVLPT G     S L +  F KR ++   +K+  
Sbjct: 358 YVRHAGAVFLGAYSPEPLGDYFAGPNHVLPTGGTARFYSVLNVETFMKRTSIISYTKDAL 417

Query: 401 SALASTIETLAAAERLTAHKNAVTLRVNALKE 432
             + + I  LA AE L AH NAV LR    K+
Sbjct: 418 HDVEADIIRLAEAEGLHAHANAVRLRSKERKD 449


>UniRef50_C0QG33 Histidinol dehydrogenase n=4 Tax=Deltaproteobacteria
           RepID=C0QG33_DESAH
          Length = 432

 Score =  545 bits (1405), Expect = e-153,   Method: Composition-based stats.
 Identities = 177/435 (40%), Positives = 249/435 (57%), Gaps = 13/435 (2%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFD--KT 61
             I  + S   EQ+    ++  +  +    R V   +++V+ RGD+AL EY+ +FD  + 
Sbjct: 1   MKIYTYPSPEGEQRICDTLKRGLGFTPENQRAVEAYIEDVRTRGDQALVEYTNQFDSSQV 60

Query: 62  TVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVT 121
           T   LKVS +EI  A   +  +  +A+  AV  + TFH+ Q+        + GV   Q+ 
Sbjct: 61  TRDTLKVSQQEIEEAKTLVDSDFSRALDRAVDQLGTFHSRQRQNSWIDTPRNGVMVGQMV 120

Query: 122 RPVASVGLYIPG---GSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQ 174
            PV + G+Y PG   G  PL S+VLM   PA +AG K   L +PP     I   +L AA 
Sbjct: 121 NPVDAAGIYAPGAKGGKTPLVSSVLMGGIPARVAGVKSCCLMTPPMENGKINPYMLVAAD 180

Query: 175 LCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPA 234
             G+  +F  G A AIAALAFGTESVPKVD I GPGN FVT AK+ VS  +    IDM A
Sbjct: 181 RVGINAIFKAGSAWAIAALAFGTESVPKVDVIVGPGNIFVTLAKKIVSGIV---GIDMIA 237

Query: 235 GPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPR 294
           GPSE+L+IAD GA PD +A+DLLSQAEH P +  IL+T + +MA R   A+E Q+  L R
Sbjct: 238 GPSEILIIADKGANPDHIAADLLSQAEHDPMASAILVTDSMEMATRTKAALEIQVKALGR 297

Query: 295 AETARQALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDW 353
            + A+++++    ++   D+   + ++N+  PEHL +   N  + V  I +AG+VFLG +
Sbjct: 298 RQIAQRSIDDFGAIMKVPDIDTAIALANRLAPEHLELIVDNPFDQVGKIKNAGAVFLGPY 357

Query: 354 SPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAA 413
           +PE  GDY +G NHVLPT G     S+LG+ +F KR ++   SKE F   A  +  LA  
Sbjct: 358 TPEPMGDYIAGPNHVLPTAGTARFSSALGVDNFTKRTSLINYSKEAFDREAQDVMVLANI 417

Query: 414 ERLTAHKNAVTLRVN 428
           E L AH N+V +R  
Sbjct: 418 EGLGAHANSVRIRTK 432


>UniRef50_C9KKX1 Histidinol dehydrogenase n=1 Tax=Mitsuokella multacida DSM 20544
           RepID=C9KKX1_9FIRM
          Length = 447

 Score =  544 bits (1403), Expect = e-153,   Method: Composition-based stats.
 Identities = 156/433 (36%), Positives = 242/433 (55%), Gaps = 9/433 (2%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
             T   ++      + +   +       +    V  I+ +V+  GD A+  Y+   D+  
Sbjct: 17  MLTKASFDEVELSPKIREANKKTFGRDMTAAELVRQIVGDVRREGDAAVIRYTHLIDRVD 76

Query: 63  --VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQV 120
                  V+  E  AA +     + +++  A +N+  +H  QK        + G    Q 
Sbjct: 77  YKPEDFLVTEAEYEAAEKAADPAVVESLRKAAENVRRYHQEQKPNSWMTYREKGSILGQS 136

Query: 121 TRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCG 177
             P+  VG+Y+PGG+A   S+V+M A PAS+AG  ++++  PP    I   +L AA+  G
Sbjct: 137 IIPLDRVGIYVPGGTAAYPSSVIMNAVPASVAGVGEIIMMVPPKNGKINPYVLIAARAAG 196

Query: 178 VQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPS 237
           V+ ++ +GGAQAIAA+AFGTE++P+VDKI GPGN FVT AK++V   +D   IDM AGPS
Sbjct: 197 VKKIYKIGGAQAIAAMAFGTETIPRVDKITGPGNIFVTLAKKEVYGHVD---IDMLAGPS 253

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAET 297
           E+L++AD  A P + A+D+LSQAEH P +  I++T  A++A +VA+  E+QLA LPR E 
Sbjct: 254 EILIVADKTADPVYTAADMLSQAEHDPLASSIVITDDAELAEKVAKEAEKQLAALPRREI 313

Query: 298 ARQALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPE 356
           A+ +++    ++V  D+ Q +  +N   PEH+ + T    +L+  +  AG+VFLG +SPE
Sbjct: 314 AQASIDRNGLIVVADDMMQAMRFANVSAPEHMELLTAQPFQLLPYVRHAGAVFLGAYSPE 373

Query: 357 SAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERL 416
             GDY +G NHVLPT G     S L +  F KR ++   ++   S ++  I  LA  E L
Sbjct: 374 PLGDYFAGPNHVLPTGGTARYYSVLNVETFMKRTSIISYTQPALSDVSEDIIRLAETEGL 433

Query: 417 TAHKNAVTLRVNA 429
            AH NA+ +R   
Sbjct: 434 QAHANAIRIRREQ 446


>UniRef50_B2KCM4 Histidinol dehydrogenase n=1 Tax=Elusimicrobium minutum Pei191
           RepID=B2KCM4_ELUMP
          Length = 429

 Score =  543 bits (1401), Expect = e-153,   Method: Composition-based stats.
 Identities = 198/433 (45%), Positives = 280/433 (64%), Gaps = 9/433 (2%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
             I ++ + T ++ + L  R  +   E + + V +    V  RGD+A++E +A FD  T+
Sbjct: 1   MKIYNYATLTKKEIKALSERSYL-MPEKLKQAVWETGLQVMKRGDKAIKELTAAFDGVTL 59

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQ-KLPPVDVETQPGVRCQQVTR 122
           ++LKVS +E   A + +S+ELK A+  A +NI  FH +Q K     +ET  G+ C +  +
Sbjct: 60  SSLKVSVKEFKQAEKLVSNELKDAIKTASENIAKFHKSQLKTKEPVIETSKGIECWREFK 119

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGV 178
            + + GLY+PGGSAPLFSTVLMLA PA IAGCKKV +C+PP     IA EIL+AA+  GV
Sbjct: 120 ALGTAGLYVPGGSAPLFSTVLMLAVPAKIAGCKKVYICTPPCKNGLIAPEILFAAKTAGV 179

Query: 179 QDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSE 238
            +V+ +GGAQA+ A+A+GT++VPK DKIFGPGN +VT+AK +VS      AIDMPAGPSE
Sbjct: 180 DEVYKIGGAQAVFAMAYGTQTVPKADKIFGPGNQYVTQAKMEVSS---FTAIDMPAGPSE 236

Query: 239 VLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETA 298
           VL+IA+      + A+D+LSQAEHGPDSQ +L   + +  + +   V+ QL +L R   A
Sbjct: 237 VLIIAEESTNASYAAADILSQAEHGPDSQAVLACSSKNKIKEIIAEVDAQLKKLGRKSIA 296

Query: 299 RQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESA 358
            +AL  S ++ T++  + VE SN Y PEHLI+  ++ ++ + S+ +AGSVF G  + ES 
Sbjct: 297 AKALGKSFIMQTRNTKESVEFSNIYAPEHLILNFKDWKKYLTSVQNAGSVFCGTLATESF 356

Query: 359 GDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTA 418
           GDYASGTNH LPT G+  +   L    F K +T Q +S +G   L  T+E +A AE LTA
Sbjct: 357 GDYASGTNHTLPTSGFAKSFGGLNTQSFGKWITYQTVSAQGLRGLGKTVEIMAEAEGLTA 416

Query: 419 HKNAVTLRVNALK 431
           HKNAVT+R+   K
Sbjct: 417 HKNAVTIRIENEK 429


>UniRef50_Q5FS83 Histidinol dehydrogenase n=3 Tax=Bacteria RepID=HISX_GLUOX
          Length = 430

 Score =  542 bits (1396), Expect = e-152,   Method: Composition-based stats.
 Identities = 177/432 (40%), Positives = 252/432 (58%), Gaps = 9/432 (2%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
              +D ++    +    L+    S   S+   V  IL +V++RGDEAL +Y+A+FD+ T+
Sbjct: 1   MKRLDTSAAGFSEDFATLLAARGSDERSVAEPVRAILADVRSRGDEALCDYTARFDRLTL 60

Query: 64  --TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVT 121
               L++SAEEIA+ + R+  +L  A+  A + IETFH AQ    +D   + G+R     
Sbjct: 61  PAEKLRISAEEIASEAARVPADLMDALRTAARRIETFHAAQMPKDLDFTDEDGIRLGMRW 120

Query: 122 RPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCGV 178
            P+ +VGLY+PGG A   S+VLM A PA +AG K++ +C P P   +   +L AAQLCGV
Sbjct: 121 TPLDAVGLYVPGGKAAYPSSVLMNALPARVAGVKRLAMCVPSPDGVLNPLVLAAAQLCGV 180

Query: 179 QDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSE 238
           ++++ +GGAQA+ A+AFGT+ +  VD+I GPGNA+V EAKRQV   +    ID  AGPSE
Sbjct: 181 EEIYRIGGAQAVGAMAFGTDLIAPVDRIVGPGNAYVAEAKRQVFGHV---GIDSIAGPSE 237

Query: 239 VLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETA 298
           V+V+AD    P  VA DLL+QAEH   +Q IL+T  A  A R AEAV ++L  LPR   A
Sbjct: 238 VVVVADGQNDPRLVALDLLAQAEHDEQAQAILITTDAAFAERAAEAVRKELETLPRTAIA 297

Query: 299 RQAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPES 357
            ++  +   +IV + L +  EI N   PEHL +     R+    I  AG++F+G + PE+
Sbjct: 298 SKSWEDHGAIIVVRSLEEAAEIVNALAPEHLEVMLDAPRDFSAMIRHAGAIFMGRYCPEA 357

Query: 358 AGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLT 417
            GDY  G NHVLPT       S L + DF KR T  E  + G   +      LA AE L 
Sbjct: 358 VGDYVGGPNHVLPTSRTARFASGLSVFDFIKRTTTIEADEAGLRRIGPAGVALAKAEGLD 417

Query: 418 AHKNAVTLRVNA 429
           AH  ++++R+  
Sbjct: 418 AHALSLSVRLEK 429


>UniRef50_Q1Q2D0 Histidinol dehydrogenase n=1 Tax=Candidatus Kuenenia
           stuttgartiensis RepID=Q1Q2D0_9BACT
          Length = 439

 Score =  541 bits (1394), Expect = e-152,   Method: Composition-based stats.
 Identities = 167/439 (38%), Positives = 264/439 (60%), Gaps = 13/439 (2%)

Query: 4   NTIIDWNSCTAEQQRQLLMRP--AISASESITRTVNDILDNVKARGDEALREYSAKFDKT 61
             I+    C A  + + + +    +++S  I  TV  I+ +VK  GD+A+  Y  +FDK 
Sbjct: 1   MRILKTWECDASLEIEKIKQGLDPLNSSSDIRTTVLKIIQDVKKNGDKAIAAYGKRFDKA 60

Query: 62  TVTA--LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQ 119
            ++    +V  EEI  A + ++ +  +A+ +A+KNI+T+    ++  V      GV    
Sbjct: 61  PLSPEQFRVKEEEIEDAYKYVTGKFIKAIRLAIKNIQTYQNHIRIQNVKPLRSKGVILDT 120

Query: 120 VTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQL 175
           +  P+ S G+Y+PGG+A   STVLM A PA +AG +K+V+ SPP     I  E L AA+ 
Sbjct: 121 IYTPIDSAGIYVPGGAASYPSTVLMNAIPAQVAGVEKIVMVSPPKEDGNIPPERLVAAKE 180

Query: 176 CGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAG 235
            GV +++ +GG QAIAALAFGT+++P VDKI GPGN FVT AK+++      A IDM AG
Sbjct: 181 AGVSEIYKIGGVQAIAALAFGTKTIPSVDKIVGPGNVFVTLAKKEIFGY---AGIDMLAG 237

Query: 236 PSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRA 295
           PSEVL+IAD+ A P ++ASDLLSQAEH P    +L+T +  +A++V   +  Q+  L R+
Sbjct: 238 PSEVLIIADNHANPSYIASDLLSQAEHTPG-ISLLVTSSKLLAKQVLAEITLQIKTLSRS 296

Query: 296 ETARQAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWS 354
               + L     + +TK++ +C+ +SN   PEHL I T+N + ++  I  AG+VF+GD++
Sbjct: 297 AGTNECLCKYGVIFITKNMNECIALSNAIAPEHLQIMTQNPKAVLSGIKHAGAVFVGDYT 356

Query: 355 PESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAE 414
           P + GDY +G +HVLPT G     S L + DF KR +V   S+    ++   +  ++A+E
Sbjct: 357 PVALGDYIAGPSHVLPTGGTARFSSGLSVNDFIKRTSVITYSQSALRSVQQDVSEISASE 416

Query: 415 RLTAHKNAVTLRVNALKEQ 433
            L AH  +V +R+++ +++
Sbjct: 417 GLDAHAKSVKIRLDSGRKK 435


>UniRef50_D2RJQ0 Histidinol dehydrogenase n=7 Tax=Firmicutes RepID=D2RJQ0_ACIFE
          Length = 448

 Score =  539 bits (1389), Expect = e-152,   Method: Composition-based stats.
 Identities = 176/451 (39%), Positives = 257/451 (56%), Gaps = 27/451 (5%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISA---SESITRTVND--------------ILDNVKAR 46
             + D    TAE+  +LL + +      S  +   V                I+++++ +
Sbjct: 1   MKVYDERKSTAEEISRLLEKKSFDEVKLSPKVAAAVEKMFGRPLTAAEEVDIIVNDIRNK 60

Query: 47  GDEALREYSAKFDKTTVTA--LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKL 104
           GDEAL EY+ K D   +    ++V+ EE A A + + ++   A+  A+ N+  FH  Q  
Sbjct: 61  GDEALFEYTKKLDGADLRPATIRVTEEEFAEAEKAVDEKTMGAIRRAIANVRKFHEEQLP 120

Query: 105 PPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSP-- 162
                    G    Q   PV SVG+Y+PGG+A   S+V+M A PA +AG  ++ + +P  
Sbjct: 121 KTWLTPRAYGSFLGQKMTPVDSVGIYVPGGTAAYPSSVIMNAVPAKVAGVPRIAMAAPAG 180

Query: 163 --PPIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQ 220
               +   +L  A+  G+ +++ +GGAQAIAALAFGTE++PKV+KI GPGN FVT AK+ 
Sbjct: 181 RDGKMNPYVLATAKEIGITEIYKMGGAQAIAALAFGTETIPKVEKITGPGNIFVTLAKKA 240

Query: 221 VSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARR 280
           V   +D   IDM AGPSE+L++AD  A   ++A+DLLSQAEH P +  IL+T   D+A +
Sbjct: 241 VYGHVD---IDMLAGPSEILIVADKTADYQYLAADLLSQAEHDPLACAILITDDEDLAGK 297

Query: 281 VAEAVERQLAELPRAETARQALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELV 339
           VAE VE QL +LPR E A Q+L    ++I+ KD+   VE++N   PEH+ I TR    LV
Sbjct: 298 VAEEVEVQLQKLPRKEIAAQSLAVQGKIILAKDMDTVVEMANISAPEHMEINTREPFALV 357

Query: 340 DSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEG 399
             I +AG++FLG +SPE  GDY +G NH+LPT G     S L +  F K+ ++   +KE 
Sbjct: 358 PRIRNAGAIFLGAYSPEPLGDYYAGPNHILPTGGTARFYSVLNVETFMKKTSIISYTKEA 417

Query: 400 FSALASTIETLAAAERLTAHKNAVTLRVNAL 430
            +  A  I  +A AE L AH NA+ +R  AL
Sbjct: 418 LAEAADDIIAMAEAEGLQAHANAIRIRKGAL 448


>UniRef50_B2A652 Histidinol dehydrogenase n=1 Tax=Natranaerobius thermophilus
           JW/NM-WN-LF RepID=B2A652_NATTJ
          Length = 428

 Score =  538 bits (1386), Expect = e-151,   Method: Composition-based stats.
 Identities = 165/421 (39%), Positives = 245/421 (58%), Gaps = 11/421 (2%)

Query: 16  QQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAA 75
           ++ +L  + A         TV  I+D V+  GD+AL E +   D  +++ L+VS E +  
Sbjct: 5   KEAKLASQKAKFEDVETRNTVTKIIDQVRTNGDKALFELTQSLDNCSLSKLEVSQEYMKQ 64

Query: 76  ASERLSDELKQAMAVAVKNIETFHTAQK--LPPVDVETQPGVRCQQVTRPVASVGLYIPG 133
             + L+D+ K+A+  A   IE F + Q      ++ E  PGV+     +P++S G Y+P 
Sbjct: 65  CYDNLTDKTKEALNFAKDQIEFFASQQLAGFKEIECENIPGVKLGYKIKPISSCGCYVPA 124

Query: 134 GSAPLFSTVLMLATPASIAGCKKVVLCSPP-----PIADEILYAAQLCGVQDVFNVGGAQ 188
           G  PL S+ LM   PA +AG +++V  +PP      I  E+L A  L GV +V+ VGGA 
Sbjct: 125 GRYPLPSSALMSIVPARVAGVERIVAIAPPVRKYGGIHPELLAAMYLAGVDEVYIVGGAH 184

Query: 189 AIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGAT 248
            IAALA GTE++ KVD I GPGN +VTEAKRQ++  +    ID  AGPSEVL+IAD+ A+
Sbjct: 185 GIAALALGTETISKVDFIVGPGNKYVTEAKRQLNGIV---GIDQLAGPSEVLIIADNTAS 241

Query: 249 PDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRL 307
              VA+DLL+QAEH PD+  +L+T +  +A+ V + + RQL EL   ETA ++  +   +
Sbjct: 242 STNVAADLLAQAEHDPDAVCVLVTTSEQLAKEVNQEIHRQLDELLTWETAAKSWEDYGEI 301

Query: 308 IVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNH 367
           I+  +L Q +EIS+Q  PEHL + T N   +++ +   GS+F+G+W+  + GDY SGTNH
Sbjct: 302 ILVDNLDQAIEISDQMAPEHLQLMTDNNSNIMEMVNHYGSLFVGEWASVAFGDYVSGTNH 361

Query: 368 VLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRV 427
           +LPT       S L +  F K  + Q L++ G   L+     LA  E L AHK +  LR 
Sbjct: 362 ILPTGNSARFSSGLSVGKFLKMSSYQVLTETGAHELSDKCMHLAELEGLEAHKKSAELRA 421

Query: 428 N 428
           +
Sbjct: 422 D 422


>UniRef50_B3WED5 Histidinol dehydrogenase n=21 Tax=Bacilli RepID=B3WED5_LACCB
          Length = 430

 Score =  538 bits (1386), Expect = e-151,   Method: Composition-based stats.
 Identities = 178/433 (41%), Positives = 250/433 (57%), Gaps = 8/433 (1%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
             I+   + +  +Q+  + R A++ +  +   V  I+  V+A GD ALR YS K D  TV
Sbjct: 1   MKIL-TGTLSQLKQQVDIRRTAVAQNTDVQTIVQAIIAKVRAEGDSALRTYSNKLDHVTV 59

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRP 123
              +V    I AA  +L  +L +A+ +A  NI ++H  +           G+   Q   P
Sbjct: 60  NDFQVDQALIDAAPAQLPAKLLKALQLAKANITSYHQNEIERGFVDTPNSGIIRGQKITP 119

Query: 124 VASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP---PIADEILYAAQLCGVQD 180
           +A+VGLY+PGG+A   ST+LM A PA +AG KK+V+ +PP    +   +L AA L GV  
Sbjct: 120 LAAVGLYVPGGTAAYPSTILMTAIPAKLAGVKKIVMVTPPQPDGLNPVVLAAANLAGVDA 179

Query: 181 VFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVL 240
           ++ VGGAQAIAALA+GTES+P+VDKI GPGN +V EAK+QV   +   AIDM AGPSE+ 
Sbjct: 180 IYQVGGAQAIAALAYGTESIPRVDKIMGPGNRYVAEAKKQVFGNV---AIDMIAGPSEIG 236

Query: 241 VIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQ 300
           +IAD  A P  +A+DLLSQAEH P+++ +++T +  +A  V+E ++ QL  LPR   AR 
Sbjct: 237 IIADESADPIRLAADLLSQAEHDPNARAMMVTTSEKLASAVSEQIDIQLPTLPRESIARA 296

Query: 301 ALNA-SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAG 359
           A+     + +   +     + N   PEHL +Q  +    +  I +AGSVFLG  + E  G
Sbjct: 297 AIENQGFIAIVATINDAFSLMNTIAPEHLEVQLPDPITYLAQIQNAGSVFLGQNAAEPVG 356

Query: 360 DYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAH 419
           DY +G NHVLPT G     S LG+ DF KR    + S E  ++ A  I TLA AE L  H
Sbjct: 357 DYVAGPNHVLPTAGSARFFSPLGVYDFVKRTQFIQYSSEALASQADAIVTLAQAEGLDGH 416

Query: 420 KNAVTLRVNALKE 432
             A+  RV A KE
Sbjct: 417 AEAIIKRVPAAKE 429


>UniRef50_C4V2I6 Histidinol dehydrogenase n=1 Tax=Selenomonas flueggei ATCC 43531
           RepID=C4V2I6_9FIRM
          Length = 448

 Score =  537 bits (1385), Expect = e-151,   Method: Composition-based stats.
 Identities = 165/434 (38%), Positives = 250/434 (57%), Gaps = 11/434 (2%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
                D     A  + +         + S    V+ I+ +V++ GD+AL  Y+   D   
Sbjct: 19  MKKAFDEIELGASMRAKNQEIFGEDLTAS--ELVHHIVRDVRSGGDQALLRYTKLLDGLD 76

Query: 63  VTA--LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQV 120
           +++  + VS  E+ AA+++    +  ++  A KNI  FH  QK          G    Q 
Sbjct: 77  LSSTDIMVSESELQAAADQADAAVLASLERAAKNIFAFHEEQKPKSWMTYRAHGSILGQE 136

Query: 121 TRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCG 177
             P++ VG+Y+PGG+A   S+VLM A PA +AG   +++  P     +   +L AA + G
Sbjct: 137 VIPLSRVGIYVPGGTAAYPSSVLMNAIPAIVAGVDDIIMSVPTKGGVLNPYVLAAAHMLG 196

Query: 178 VQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPS 237
           ++ +F VGGAQAIAA+A+GTES+P+VDKI GPGN FVT AK++V   +D   IDM AGPS
Sbjct: 197 IKKIFRVGGAQAIAAMAYGTESIPRVDKITGPGNLFVTLAKKEVYGYVD---IDMLAGPS 253

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAET 297
           E+L++AD  A+P ++A+D+LSQAEH P +  IL+T +AD+A  V   ++ QL  LPR ET
Sbjct: 254 EILILADEEASPKYIAADMLSQAEHDPLASSILITDSADLASNVRCEIQDQLQSLPRMET 313

Query: 298 ARQALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPE 356
           A  +L    R+IVT+++ Q V ++N  GPEH+ +  ++A  L+  I  AG+VF+G +SPE
Sbjct: 314 ASASLERNGRIIVTENIQQSVHLANYSGPEHIELLVKDAFHLLPEIRCAGAVFVGSYSPE 373

Query: 357 SAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERL 416
             GDY +G NHVLPT G     S L +  F KR ++   +++    ++  I  LA  E L
Sbjct: 374 PLGDYFAGPNHVLPTGGTARFYSVLNVETFMKRTSIISYTRKALDEVSDDIIRLAETEGL 433

Query: 417 TAHKNAVTLRVNAL 430
            AH  A+  R + +
Sbjct: 434 EAHARAIRTRRDNI 447


>UniRef50_C3XDE7 Histidinol dehydrogenase n=1 Tax=Helicobacter bilis ATCC 43879
           RepID=C3XDE7_9HELI
          Length = 452

 Score =  537 bits (1384), Expect = e-151,   Method: Composition-based stats.
 Identities = 156/455 (34%), Positives = 242/455 (53%), Gaps = 28/455 (6%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              I++ +    E +   L+  A +  +SI   V   L ++K RG++AL +   K+D   
Sbjct: 1   MIKILNIHDKDFETEFNTLLARANTDMDSIIPEVLKTLQDIKQRGEDALLDIVRKYDSWN 60

Query: 63  V---TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQ 119
                 LK++ E+   A + L  + K A+ +A   I TFH            +      Q
Sbjct: 61  PQTFNDLKIAEEDTFNAYKNLDSKTKDALQIAHDRIYTFHAKNAPKGFIYHDEYANMLGQ 120

Query: 120 VTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLC 176
              P+   G+YIPGG A   S++LM A PA +AG K++++ SP P   I + +L A  LC
Sbjct: 121 NIMPIQRAGIYIPGGKAFYPSSLLMNAIPAKVAGVKEIIMASPTPNNHINELVLAAMYLC 180

Query: 177 GVQDVFNVGGAQAIAALAFG--------------TES----VPKVDKIFGPGNAFVTEAK 218
           G+++ + +GG  AI   A+G              T++      KVD I GPGN +V  AK
Sbjct: 181 GIKEGYKIGGIGAIGMFAYGFGETKWSKDSLFSHTKTTQKGFKKVDVITGPGNIYVATAK 240

Query: 219 RQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMA 278
           + V   ++   IDM AGPSE+ +IADS A  D++A D+LSQAEH   +  IL+T   D+A
Sbjct: 241 KLVFGEVN---IDMIAGPSEIGIIADSHANSDYLAIDMLSQAEHDSMASAILITDNKDLA 297

Query: 279 RRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARE 337
           + VA+ ++ +L  L R + A++++     +I+ ++L Q   + N   PEHL I T+    
Sbjct: 298 KEVAQKIDTKLTHLMRKDIAQKSIQERGAIIIVENLKQAAMLMNAIAPEHLEIVTQEPFS 357

Query: 338 LVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSK 397
           L+  I +AG+VFLG ++PE+ GDY +G NH LPT G     S LG+  F  R ++   SK
Sbjct: 358 LLGEIKAAGAVFLGHYTPEAIGDYLAGPNHTLPTGGSARFFSPLGVEHFCTRSSLISFSK 417

Query: 398 EGFSALASTIETLAAAERLTAHKNAVTLRVNALKE 432
           +G   LA+    LA  E L AHK +V  R++++K+
Sbjct: 418 QGIKNLANPCAILAETEGLEAHKLSVISRLDSMKD 452


>UniRef50_Q2PPB3 Histidine biosynthesis trifunctional protein n=12 Tax=Phaeosphaeria
           RepID=Q2PPB3_PHANO
          Length = 881

 Score =  537 bits (1384), Expect = e-151,   Method: Composition-based stats.
 Identities = 199/432 (46%), Positives = 265/432 (61%), Gaps = 8/432 (1%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
                    T+E     L RP+  ++  I      I+D VK RGD AL EY+ KF+K T 
Sbjct: 447 MKRYVTAQETSETIAAALQRPSQKSTGKIIGICRPIIDAVKTRGDAALLEYTHKFEKATS 506

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKL-PPVDVETQPGVRCQQVTR 122
               V          +L+ E  +A+ V+ +NI  FH AQ+   P+ VET PGV C +  R
Sbjct: 507 LTSPVLRAPFPPELMQLAPETAKAIDVSFENIRKFHAAQREEKPLVVETMPGVVCSRFAR 566

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGV 178
           P+  VGLY+PGG+A L ST LML  PA +AGCKK+VL +PP     +  E++YAA   G 
Sbjct: 567 PIERVGLYVPGGTAVLPSTALMLGVPAMVAGCKKIVLATPPRSNGKVTPEVVYAAHKVGA 626

Query: 179 QDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLD-GAAIDMPAGPS 237
           + +   GGAQA+AA+A+GTESV KVDKI GPGN FVT AK  VS   + G +IDMPAGPS
Sbjct: 627 EMIVLAGGAQAVAAMAYGTESVSKVDKILGPGNQFVTAAKMHVSNDTNAGVSIDMPAGPS 686

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTP--AADMARRVAEAVERQLAELPRA 295
           E+LVIAD+ A P FVASDLLSQAEHG DSQVIL+           + + + +Q   LPR 
Sbjct: 687 ELLVIADASANPAFVASDLLSQAEHGVDSQVILIAVGLNEAQLTAIEDELHKQANALPRV 746

Query: 296 ETARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSP 355
           +  R A+  S  +    + + +E+SNQY PEHLI+Q  NA ++V+ + +AGSVF+G+W+P
Sbjct: 747 DIVRGAIEHSLTLAASTIEEALELSNQYAPEHLILQVANADKVVELVENAGSVFIGEWTP 806

Query: 356 ESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAER 415
           ES GDY++G NH LPTYGY    S + LA + K +T   L+KEG   +   +  LA  E 
Sbjct: 807 ESVGDYSAGVNHSLPTYGYAKQYSGVNLASYVKHITSAHLTKEGLQNVGPAVMELARVEE 866

Query: 416 LTAHKNAVTLRV 427
           L AH+ AV+LR+
Sbjct: 867 LEAHRRAVSLRL 878


>UniRef50_Q3J079 Histidinol dehydrogenase 1 n=26 Tax=Proteobacteria
           RepID=HISX1_RHOS4
          Length = 434

 Score =  536 bits (1382), Expect = e-151,   Method: Composition-based stats.
 Identities = 171/436 (39%), Positives = 242/436 (55%), Gaps = 9/436 (2%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
               +D      E     L+      S  +   V  I+ +V+ARGD A+ E +A+FD+  
Sbjct: 1   MPQFLDTRRPGFEADFTALLGMKREDSPDVDAVVAGIIADVRARGDAAVIELTARFDRLE 60

Query: 63  VTALKV--SAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQV 120
           +T  ++  S  EI A    +S E + A+ +A + I  +H  Q           G      
Sbjct: 61  LTPERLAFSEAEIEAEIATVSAEDRAALELAAERIRAYHARQMPENARWTDAAGAELGWR 120

Query: 121 TRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCG 177
             P+AS GLY+PGG A   S+VLM A PA +AG +++V+  P P   +   +L AA+L G
Sbjct: 121 WGPIASAGLYVPGGLASYPSSVLMNAIPARVAGVERLVVACPTPGGVVNPLVLLAARLAG 180

Query: 178 VQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPS 237
           V  V+ +GGAQA+AALA+GTE++  VDKI GPGNA+V  AKR+V  R+    IDM AGPS
Sbjct: 181 VDAVYRIGGAQAVAALAYGTETIRPVDKITGPGNAYVAAAKRRVFGRV---GIDMIAGPS 237

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAET 297
           E+LVIA+    PD++A DLLSQAEH   +Q IL+TP   + R V +AVE +L  L R   
Sbjct: 238 EILVIAEGAVDPDWIALDLLSQAEHDESAQSILVTPDEALGRAVVQAVEARLETLERRAI 297

Query: 298 ARQAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPE 356
           A  +  +   +IVT+DL +   +S++  PEHL +   +   L   I  AG++FLG W+PE
Sbjct: 298 AGASWRDYGAVIVTRDLEEAAALSDRVAPEHLELCVADPEALAARIRHAGAIFLGGWTPE 357

Query: 357 SAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERL 416
           + GDY  G NHVLPT       S L + DF KR T+  ++     A+    E LA +E L
Sbjct: 358 AIGDYVGGPNHVLPTARSARFSSGLSVMDFLKRTTLARMTPAALRAVGPAAERLAISESL 417

Query: 417 TAHKNAVTLRVNALKE 432
            AH  +V  R++ L E
Sbjct: 418 EAHGLSVRARLDRLNE 433


>UniRef50_B3TCH3 Putative Histidinol dehydrogenase n=1 Tax=uncultured marine
           microorganism HF4000_APKG10K24 RepID=B3TCH3_9ZZZZ
          Length = 444

 Score =  536 bits (1382), Expect = e-151,   Method: Composition-based stats.
 Identities = 159/434 (36%), Positives = 244/434 (56%), Gaps = 13/434 (2%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
              +D +        +         S    ++V  +L +V+  GD A+R YS   D   +
Sbjct: 15  IDPLDLSDLPKAVLDRTHQAFGEDVSPE--QSVLKMLQDVRQDGDAAVRRYSKLLDGVEL 72

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRP 123
           ++ KV  E++A A+  +S EL++++ +A + I  FH A        E        Q+ RP
Sbjct: 73  SSFKVEKEQLAQAAASVSTELRESLELAAERIRQFHQAVMPKDWLDEEGG---LGQLVRP 129

Query: 124 VASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQ 179
           +  VGLY PGG+A   STVLM A PA +AG  +V+LC+P      +   +L AA++ GV 
Sbjct: 130 LERVGLYAPGGTAAYPSTVLMTAIPARVAGVNEVILCTPARPGEALNPAVLVAAEISGVD 189

Query: 180 DVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEV 239
            V+ +GG  AI A+A+GT+SVPKVDKI GPGN FV  AK+ V  ++D   ID   GP+E 
Sbjct: 190 TVYQIGGVPAIGAMAYGTDSVPKVDKICGPGNVFVAYAKKLVQGQVD---IDGVFGPTET 246

Query: 240 LVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETAR 299
           +VIAD  A P F A+DL+ QAEH P +  IL+T + D+  RV   ++ QL    R + AR
Sbjct: 247 VVIADESADPGFCAADLIGQAEHDPLATAILITDSQDLIDRVERELDEQLNIQLRGDLAR 306

Query: 300 QALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESA 358
           QAL    R+++ + +A+ VE++++  PEH+ +  ++  +   ++  AG +FLG++SPE  
Sbjct: 307 QALERQGRIVLVESVAEAVELADRIAPEHMCLMVQDPWKWAGTVKHAGGLFLGEYSPEVM 366

Query: 359 GDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTA 418
           GDY +G +HV+PT G     S+L +  F + M V  LS + F  L      +A AE L  
Sbjct: 367 GDYVAGPSHVMPTGGTARFSSALSVHQFLRTMPVVSLSADDFQKLGPAAIEIAKAEGLDG 426

Query: 419 HKNAVTLRVNALKE 432
           H  AV +R++ L++
Sbjct: 427 HATAVRMRLDKLQK 440


>UniRef50_C1PFR7 Histidinol dehydrogenase n=1 Tax=Bacillus coagulans 36D1
           RepID=C1PFR7_BACCO
          Length = 427

 Score =  535 bits (1380), Expect = e-151,   Method: Composition-based stats.
 Identities = 152/429 (35%), Positives = 234/429 (54%), Gaps = 8/429 (1%)

Query: 5   TIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVT 64
            I ++      +        +    E + RT  ++L++++  GD A+++Y+AKFD     
Sbjct: 1   MIREYTKEAFAETFLQSKNKSGVHDEGVLRTAKEVLEDIRLNGDAAVKKYTAKFDGEVPE 60

Query: 65  ALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPV 124
           + +V  EE   A   +  ++  A+  A +NI  FH  Q      +E    +   Q+ RPV
Sbjct: 61  SWEVLPEERKQAWHEVPQDVISALQKAAENIRRFHAKQLQNSRIMEMNENIISGQLFRPV 120

Query: 125 ASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQD 180
              G+Y+PGG+A   S+VLM A PA +AG ++V++ +P      IA  +  AA + GV  
Sbjct: 121 EKAGIYVPGGTACYPSSVLMNAIPAVLAGVEEVIMATPARNGTKIAPVLSVAADIAGVGT 180

Query: 181 VFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVL 240
           ++ +GG QAI ALA+GTE++PKVDKI GPGNA+V  AK  V   +    IDM AGPSEV 
Sbjct: 181 IYKLGGIQAIGALAYGTETIPKVDKIVGPGNAYVAAAKSLVYGTV---GIDMIAGPSEVA 237

Query: 241 VIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQ 300
           +IAD  A P ++A+DL++QAEH   ++  L T +  +      A+E+QL  LPR +    
Sbjct: 238 IIADENANPVYIAADLIAQAEHDERARTFLFTTSQKLINETKSALEKQLVVLPRRDIGEV 297

Query: 301 ALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAG 359
           ++   S  ++ + + +   +SN+  PEHL IQ  N    +  + +AGSVFLG+ +PE+ G
Sbjct: 298 SIKMQSAAVLVESIDEAFALSNRLAPEHLEIQVENPLLQLSKVKNAGSVFLGENTPEAIG 357

Query: 360 DYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAH 419
           DY  G NH+LPT G     S L + DF K++T     ++     A  +  +A  E+L  H
Sbjct: 358 DYYGGPNHILPTSGTARFSSGLSVDDFYKKITYLYYGEKALQQAAPDVMAIATEEQLAGH 417

Query: 420 KNAVTLRVN 428
             AV  RV 
Sbjct: 418 ARAVQKRVK 426


>UniRef50_Q3AR25 Histidinol dehydrogenase n=13 Tax=Bacteria RepID=HISX_CHLCH
          Length = 428

 Score =  535 bits (1380), Expect = e-150,   Method: Composition-based stats.
 Identities = 150/435 (34%), Positives = 228/435 (52%), Gaps = 14/435 (3%)

Query: 3   FNTIIDWNSCTAEQQRQLLMR--PAISASESITRTVNDILDNVKARGDEALREYSAKFDK 60
              +        ++   L  R    +S  E+  + V++IL  V+ +GD A+  Y+ +F  
Sbjct: 1   MLPLYR----FPQEASALQERLVRHVSFDEAAHKAVDEILAKVRQQGDRAVLNYTEQFQG 56

Query: 61  TTVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQV 120
             +T+++V  E I  A       L   +  A  NI  FH  +       E + GV   Q 
Sbjct: 57  VRLTSMQVDEEAIEMAYRHADPSLIATLHEAYANIVRFHEHEVERSFFYEAEGGVLLGQR 116

Query: 121 TRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSP----PPIADEILYAAQLC 176
            RP+    LY+PGG A   S++LM A PA +AG  ++ + +P      +   IL AA++ 
Sbjct: 117 VRPMERAMLYVPGGKAAYPSSLLMNAAPAKVAGVCEIAVTTPCDATGVVNPTILAAAKVA 176

Query: 177 GVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGP 236
           G+  ++ +GGAQA+AA A+GTES+PKVD I GPGN +V  AK+QV   +   AID  AGP
Sbjct: 177 GISSIYKIGGAQAVAAFAYGTESIPKVDIITGPGNKYVALAKKQVFGHV---AIDSIAGP 233

Query: 237 SEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAE 296
           SEV++IAD  A  +FVA D+ +QAEH PD+  +L+T +   A+ V +AV   L  + R E
Sbjct: 234 SEVVIIADESAHAEFVALDMFAQAEHDPDASAVLITTSESFAQAVQQAVASLLPTMLRHE 293

Query: 297 -TARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSP 355
             A   L+   +++   L     +S+   PEHL +      +++  +  AG++F+G +S 
Sbjct: 294 TIASSLLHNGAMVLVPSLDDACAVSDMLAPEHLELHVVQPWDILPKLKHAGAIFMGSYSC 353

Query: 356 ESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAER 415
           E+ GDY +G NH LPT G     S L + DF K  ++   S E   +  + I   A AE 
Sbjct: 354 ETIGDYFAGPNHTLPTSGTARFFSPLSVRDFVKHTSIISYSPEQLRSKGAQIAAFADAEG 413

Query: 416 LTAHKNAVTLRVNAL 430
           L AH  AV +R+  L
Sbjct: 414 LQAHAEAVRVRLKTL 428


>UniRef50_Q313T7 Histidinol dehydrogenase n=7 Tax=Deltaproteobacteria
           RepID=HISX_DESDG
          Length = 434

 Score =  534 bits (1377), Expect = e-150,   Method: Composition-based stats.
 Identities = 167/438 (38%), Positives = 249/438 (56%), Gaps = 14/438 (3%)

Query: 1   MSFNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFD- 59
           M   T+   +    +  R +L     +   S+   V +I+D +++ GD AL  Y+ +FD 
Sbjct: 1   MPCRTLTYSSEADWQGIRDMLC-GRENPENSVEPVVREIMDAIRSDGDAALAGYTRRFDC 59

Query: 60  -KTTVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQ 118
                ++L+V+ + I  A+  +     Q +  A  NI  FH+AQK     +    G    
Sbjct: 60  PDFDPSSLRVAPDAIEKAAREIPRHDLQIITEAADNIRHFHSAQKEEAWFITRPDGTVLG 119

Query: 119 QVTRPVASVGLYIPGGSA---PLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILY 171
           Q+TRPV S GLY+PGG     PL S++LM A PA +AG  ++ + +PP     +   IL 
Sbjct: 120 QMTRPVDSAGLYVPGGQGGNTPLISSLLMNAVPAQVAGVPRIAVTTPPRKDGTLNPYILA 179

Query: 172 AAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAID 231
           AA + G+ +++  G A A+AALA+GT+++  VD I GPGN FVT AKR +   +    ID
Sbjct: 180 AAHVLGLDEIYCAGSAWAVAALAYGTQTIAPVDFIAGPGNIFVTTAKRMLIGTV---GID 236

Query: 232 MPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAE 291
           M AGPSE+L+IADS A    VA+D+LSQAEH P +  IL+TP+  +A  V   +E+Q+  
Sbjct: 237 MIAGPSEILIIADSQADAAHVAADMLSQAEHDPLASAILVTPSPQLAAAVHTELEKQVTG 296

Query: 292 LPRAETARQAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFL 350
           L RA+ AR +L + S ++VT DL   VE+SN+  PEHL +  ++   L+ SI +AG++F+
Sbjct: 297 LDRADIARASLRDWSAIVVTPDLNSAVELSNKVAPEHLELLVQDTWGLLGSIRNAGAIFM 356

Query: 351 GDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETL 410
           G  SPE  GDY +G NHVLPT G     S+L +  F K+ ++   S+      A+ I  L
Sbjct: 357 GPHSPEPVGDYFAGPNHVLPTMGTARFSSALSVQSFCKKSSIIAASQTFTQTNAAKIARL 416

Query: 411 AAAERLTAHKNAVTLRVN 428
           A  E L AH  +V  R++
Sbjct: 417 ARLEGLEAHARSVESRLS 434


>UniRef50_Q186D5 Histidinol dehydrogenase n=9 Tax=Bacteria RepID=Q186D5_CLOD6
          Length = 421

 Score =  533 bits (1374), Expect = e-150,   Method: Composition-based stats.
 Identities = 156/407 (38%), Positives = 231/407 (56%), Gaps = 12/407 (2%)

Query: 32  ITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAMAVA 91
           +   V+ I+++++   D AL++Y+ KFD+ T    +++ EEI  A + + DE    + +A
Sbjct: 18  LREQVSSIIEDIRNNKDVALKKYNEKFDRNTRDEFRITKEEIKEAYKHVDDEFINNLKIA 77

Query: 92  VKNIETFHTAQK---LPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATP 148
            KNI  F  AQK     P + E  PGV   Q   P+ S   Y+PGG  PLFST LML  P
Sbjct: 78  AKNIREFAKAQKLSFENPFEKEIYPGVILGQTNIPIESCLAYVPGGQYPLFSTALMLIIP 137

Query: 149 ASIAGCKKVVLCSPP-----PIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKV 203
           A +AG K++V CSP       I  + L A  + G  +++  GG QAIAA  +GTE +  V
Sbjct: 138 AKVAGVKRIVACSPTMKNTEKINPKTLVAMDIAGADEIYATGGVQAIAAFTYGTEKINPV 197

Query: 204 DKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHG 263
           D I GPGN FVTEAKRQ   ++    ID  AGPSEVL+IAD  + P ++A+DLL+Q EH 
Sbjct: 198 DIIVGPGNKFVTEAKRQCYGQV---GIDFVAGPSEVLIIADETSNPVYIAADLLAQCEHD 254

Query: 264 PDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNA-SRLIVTKDLAQCVEISNQ 322
            +++ ILLT + ++A++V + +E  L +LP  + +  +      +I+  D+ + ++ISN 
Sbjct: 255 LNARGILLTNSLEVAQKVEKNIESMLKDLPTKDISYSSWENNGEIILVDDMEEAIKISNF 314

Query: 323 YGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLG 382
           Y PEHL +      ++ D +T+ GS+F+G+ S E  GDY SGTNH LPT   +     + 
Sbjct: 315 YAPEHLEVAVNEYNDICDRLTNYGSLFIGNLSAEVFGDYVSGTNHTLPTLKASRYTGGVW 374

Query: 383 LADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNA 429
           +  F K  T Q  +++   +LA   E LA  E L AH  A  +R   
Sbjct: 375 VGTFIKTCTKQIFNEKAIQSLAPVAEKLAKEEGLYAHAKAAEVRFKK 421


>UniRef50_Q46WL2 Histidinol dehydrogenase 1 n=202 Tax=Bacteria RepID=HISX1_RALEJ
          Length = 445

 Score =  531 bits (1370), Expect = e-149,   Method: Composition-based stats.
 Identities = 173/434 (39%), Positives = 243/434 (55%), Gaps = 14/434 (3%)

Query: 7   IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT---V 63
           +D +     Q  + ++       E+I R V  IL +VK RGD A+ EY+ +FD+     +
Sbjct: 14  LDSSDPRFAQALREVLAFEAGEDEAIDRAVAQILADVKDRGDAAVLEYTQRFDRVEAASM 73

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQK----LPPVDVETQPGVRCQQ 119
            AL++S  E+ AA E L  + + A+  A   +  +H  QK        +     G    Q
Sbjct: 74  GALEISQSELEAALEDLEPKRRAALEAAAARVRAYHEKQKIECGSHSWEYTEADGTMLGQ 133

Query: 120 VTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLC 176
              P+  VG+Y+PGG A   S+VLM A PA +AG K++++  P P     + +L AAQ+ 
Sbjct: 134 KVTPLDRVGIYVPGGKAAYPSSVLMNAIPARVAGVKEIIMVVPTPGGVRNELVLAAAQIA 193

Query: 177 GVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGP 236
           GV  VF +GGAQA+ ALA+GT ++P+VDKI GPGNA+V  AKR+V   +    IDM AGP
Sbjct: 194 GVDRVFTIGGAQAVGALAYGTATLPQVDKIVGPGNAYVAAAKRRVFGTV---GIDMIAGP 250

Query: 237 SEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAE 296
           SE+LVI D    PD+VA DL SQAEH   +Q ILL P AD   +V  +++RQL  +PR E
Sbjct: 251 SEILVICDGTTDPDWVAMDLFSQAEHDELAQSILLCPDADYIAQVEASIQRQLDSMPRRE 310

Query: 297 TARQALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSP 355
               +++    LI  +D+ +  EI+N   PEHL I   N R+  + I  AG++FLG ++ 
Sbjct: 311 VIAASISGRGALIKVRDMEEACEIANAIAPEHLEISAENPRQWSEKIRHAGAIFLGRYTS 370

Query: 356 ESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAER 415
           ES GDY +G NHVLPT       S LG+ DFQKR ++ E+S+ G   L      LA  E 
Sbjct: 371 ESLGDYCAGPNHVLPTSRTARFSSPLGVYDFQKRSSLIEVSEGGAQMLGQIAAELAYGEG 430

Query: 416 LTAHKNAVTLRVNA 429
           L AH  +   R   
Sbjct: 431 LQAHARSAEYRFKR 444


>UniRef50_Q5ZW87 Histidinol dehydrogenase n=6 Tax=Legionella RepID=HISX_LEGPH
          Length = 431

 Score =  530 bits (1366), Expect = e-149,   Method: Composition-based stats.
 Identities = 191/435 (43%), Positives = 277/435 (63%), Gaps = 9/435 (2%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
             TI +W   +   ++  L RP    S +I   V +I++ V+  GD+AL + + +FD+  
Sbjct: 1   MLTIKNWQLLSENDKKLCLSRPRQ--SSAIKENVLEIINQVQLSGDKALYDLTKQFDRVN 58

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
           +  L+V  E+I  A   +      A+  A+  I ++H +      ++ T  G+  + V R
Sbjct: 59  LQYLQVPQEKIEQA--NIPKNALNAITQAIGTISSYHQSLLPENTEISTASGITIRNVYR 116

Query: 123 PVASVGLYIPGG-SAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCG 177
           P+  VGLY+PGG   PL S++LM A PA +AGC   VLC+PP     I + IL AA+LCG
Sbjct: 117 PIQKVGLYVPGGNKTPLVSSLLMQAIPAKVAGCPIKVLCTPPDAEGEINEHILVAARLCG 176

Query: 178 VQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPS 237
           +  ++ +GGAQAIAA+A+GTESV KVDKIFGPGN++VT+AK  V+   DGAAIDMPAGPS
Sbjct: 177 IDTIYAIGGAQAIAAMAYGTESVIKVDKIFGPGNSYVTQAKTLVAIDADGAAIDMPAGPS 236

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAET 297
           EV+++AD+ A P+F+A+DLL+QAEHGPDSQVIL+    ++A +V + +E Q++ L R E 
Sbjct: 237 EVMILADTEANPEFIAADLLAQAEHGPDSQVILICDECELANQVNQQLEIQMSYLSRIEF 296

Query: 298 ARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPES 357
            +++L  SR+I+  + ++ ++I N Y PEHLII  +N    V+ I +AG+VFLG W+ E+
Sbjct: 297 IKRSLANSRIIICSNQSEQLDIINSYAPEHLIINRKNPEPWVEKIVAAGTVFLGSWAAET 356

Query: 358 AGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLT 417
            GDY +G+NHVLPT G+    S L   DF  R TVQ +++E    L     TLA  E L 
Sbjct: 357 MGDYVTGSNHVLPTSGFARNHSGLSTLDFMTRFTVQAINQEAIRNLGPAAMTLAELEGLD 416

Query: 418 AHKNAVTLRVNALKE 432
           AH NAV +R+N L +
Sbjct: 417 AHANAVQIRLNTLGD 431


>UniRef50_C7LV94 Histidinol dehydrogenase n=6 Tax=Desulfovibrionales
           RepID=C7LV94_DESBD
          Length = 436

 Score =  530 bits (1365), Expect = e-149,   Method: Composition-based stats.
 Identities = 159/435 (36%), Positives = 232/435 (53%), Gaps = 13/435 (2%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
              +++ S          M    +  +++   V DIL  V+ RGDEA+ EY+ +FD  ++
Sbjct: 3   LRFLEYTSPNDWTAIASWMARRDAGEDNVEPLVRDILAQVRERGDEAVAEYTRRFDCPSL 62

Query: 64  TA--LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVT 121
           +A  L V   +I  A E +  E    +  A  NI  FH  QK         PG    Q+ 
Sbjct: 63  SAAGLPVPKADIGRALELIPAEDAAIIREAAANIRDFHLRQKQNSWITTPAPGTTLGQLV 122

Query: 122 RPVASVGLYIPGGSA---PLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQ 174
            PV   GLY+PGG     PL S++LM A PA +AG   + + SPP     +   IL  A 
Sbjct: 123 LPVDRAGLYVPGGQGGETPLISSLLMNAIPAQVAGVGAICVVSPPRKDGTLNPYILATAA 182

Query: 175 LCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPA 234
           + G+  +F  G A AIAALA+GT S+P+VD I GPGN FVT AKR +  ++    IDM A
Sbjct: 183 ILGIDTIFMCGSAWAIAALAYGTASIPRVDVIAGPGNIFVTTAKRLLVGQV---GIDMIA 239

Query: 235 GPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPR 294
           GPSE+ ++ADS A P ++A+D+LSQAEH P +  IL++    +   V + + RQL  LPR
Sbjct: 240 GPSEIAILADSTANPKWLAADMLSQAEHDPLASSILISADQQLLEEVKKELARQLPALPR 299

Query: 295 AETARQAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDW 353
            E A ++L   S LI   DL   +++ N+  PEH  +   +   LV ++ +AG+VF+G  
Sbjct: 300 QEIASKSLSEWSALIHVPDLEMGMDLINRLAPEHFELSVADPWALVGAVRNAGAVFMGHS 359

Query: 354 SPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAA 413
           +PE  GDY +G NHVLPT       S+L +  F K+ ++    +   ++  S +  LA  
Sbjct: 360 TPEPVGDYFAGPNHVLPTLSTARFSSALSVDTFCKKTSLICTDQAYMNSHGSKVARLARL 419

Query: 414 ERLTAHKNAVTLRVN 428
           E L AH  +V  R+ 
Sbjct: 420 EGLEAHARSVEQRLE 434


>UniRef50_P62457 Histidinol dehydrogenase n=27 Tax=cellular organisms
           RepID=HISX_DESVH
          Length = 436

 Score =  529 bits (1364), Expect = e-149,   Method: Composition-based stats.
 Identities = 173/432 (40%), Positives = 239/432 (55%), Gaps = 13/432 (3%)

Query: 5   TIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVT 64
            I+   S         ++       +++   V DIL  V+++GDEAL EY+ +FD    T
Sbjct: 4   RILTLQSEAQWPLLGDMLAGRYDPDDAVEPVVRDILAAVRSKGDEALAEYTRRFDCPDFT 63

Query: 65  A--LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
              L V++EE+A A   +  +    +  A  NI +FH AQK     V    G    Q   
Sbjct: 64  PALLHVTSEEVAQAVASVPADDIAIIRQAADNIRSFHEAQKERSWFVTHDDGTILGQKVT 123

Query: 123 PVASVGLYIPGGSA---PLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQL 175
           PV   GLY+PGG     PL S++LM A PA +AG   + + SPP     +   +L AA +
Sbjct: 124 PVDRAGLYVPGGKGGDTPLLSSLLMNAIPAQVAGVTSITVASPPRPDGTLNPHLLAAAHI 183

Query: 176 CGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAG 235
            G+ D+   G A A+AA AFGT+++  VD I GPGN FVT AKR V  R+   AIDM AG
Sbjct: 184 LGITDIIRAGSAWAVAAFAFGTQTIAPVDVIAGPGNIFVTTAKRMVQGRV---AIDMIAG 240

Query: 236 PSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRA 295
           PSE+L++AD+ A PD+VA+D+LSQAEH P +  IL+T    +A  V   +ERQLA LPRA
Sbjct: 241 PSEILILADATARPDWVAADMLSQAEHDPLASSILVTTEPALAEAVTAELERQLATLPRA 300

Query: 296 ETARQAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWS 354
           + AR+AL +   ++V  D+   V I+N+  PEHL + T    EL  S+  AG++FLG +S
Sbjct: 301 DIARKALADWGAVVVVPDMDVAVAIANRVAPEHLEVLTAQPWELAGSLRHAGALFLGPYS 360

Query: 355 PESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAE 414
           PE  GDY +G NHVLPT G     S+L +  F KR ++   S+      A  +  LA  E
Sbjct: 361 PEPLGDYFAGPNHVLPTMGTARFSSALSVQTFCKRTSIIAASRAFAERNADAVARLARLE 420

Query: 415 RLTAHKNAVTLR 426
            L AH  +   R
Sbjct: 421 GLEAHARSAASR 432


>UniRef50_D1YWF4 Histidinol dehydrogenase n=1 Tax=Methanocella paludicola SANAE
           RepID=D1YWF4_METPS
          Length = 423

 Score =  528 bits (1362), Expect = e-148,   Method: Composition-based stats.
 Identities = 166/430 (38%), Positives = 236/430 (54%), Gaps = 13/430 (3%)

Query: 5   TIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVT 64
            I            ++  R    +S  +  T   + D V+  GD A+R+Y+ +FD   + 
Sbjct: 1   MIKQLYGVDDAALDEVFKRRTSISS--VMDTAKKVADEVREGGDAAVRKYTKQFDGVDLR 58

Query: 65  ALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPP--VDVETQPGVRCQQVTR 122
            L+V+ +E+  A E +  E    +  A+ NIE FH  Q+        E  PG+R  Q   
Sbjct: 59  DLEVTDDEMYNAVELIDYETIGHLEKAIDNIEAFHALQRPSGDMWLTEISPGIRLGQKFT 118

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGV 178
           P+  +G Y+PGG+    ST LML  PA +AG  +++ C+PP     I    L A  + G 
Sbjct: 119 PLERIGAYVPGGTGSYPSTALMLIVPAQVAGVSEIIACTPPRKDGTIHPLTLTALDMAGA 178

Query: 179 QDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSE 238
             +F VGG QAIAA+A+GT+S+PKV+KI GPGN +VT AK  V    D A IDMPAGPSE
Sbjct: 179 DRIFKVGGVQAIAAMAYGTQSIPKVEKIVGPGNIYVTAAKMYVR---DAAEIDMPAGPSE 235

Query: 239 VLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETA 298
           ++VIAD  A P F+ASD+++QAEH  ++  ILLTP+  +A  V   +ERQ    PR +  
Sbjct: 236 IVVIADDTAIPSFIASDMIAQAEHDVNAMSILLTPSEMLAESVELEIERQKENAPRRQII 295

Query: 299 RQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESA 358
            +A     + V  DL   VE+ N+  PEH+ I  R+    ++ + +AG+V++GD++P +A
Sbjct: 296 DKA--GMGIYVLDDLDAAVEVCNRIAPEHVEIMVRDPMSTLNKVRNAGTVYVGDYAPVAA 353

Query: 359 GDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTA 418
           GDYASG NHVLPT GY    S +    F K  +VQ + K G   +  TI  LA  E   A
Sbjct: 354 GDYASGANHVLPTGGYAKVFSGMNTMQFIKTTSVQVIEKGGLEGIKDTITALAEIEGFDA 413

Query: 419 HKNAVTLRVN 428
           H  +V  R  
Sbjct: 414 HARSVYKRFE 423


>UniRef50_Q4FQF8 Histidinol dehydrogenase n=6 Tax=Proteobacteria RepID=HISX_PSYA2
          Length = 431

 Score =  527 bits (1359), Expect = e-148,   Method: Composition-based stats.
 Identities = 171/431 (39%), Positives = 244/431 (56%), Gaps = 12/431 (2%)

Query: 7   IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKT---TV 63
           +       + Q   L+        ++  TV+DI+  V+  GD  + E + +FD+    T 
Sbjct: 4   LSTQDADFDSQLTELLAFETVNDATLLTTVDDIIARVRHGGDSVVLELTQQFDQHPATTT 63

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRP 123
            AL++S E +A A   L D +K A+  A   ++TFH  Q       E + G R  Q    
Sbjct: 64  QALELSKEALAEAFANLDDVVKSALITAATRVKTFHERQVQETWQYEDELGNRLGQKVTA 123

Query: 124 VASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCGVQD 180
           +  VG+Y+PGG A   S+VLM A PA +AG K+V++  P P   +   +L AA L  V  
Sbjct: 124 LDRVGIYVPGGLASYPSSVLMNAIPAKVAGVKEVIMVVPAPKGVLNPLVLAAAHLAKVDR 183

Query: 181 VFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVL 240
           VF +GGAQA+AALA+GTE++P VDKI GPGN +V  AKR V  ++    IDM AGPSEVL
Sbjct: 184 VFTIGGAQAVAALAYGTETIPAVDKITGPGNKYVAAAKRAVFGQV---GIDMIAGPSEVL 240

Query: 241 VIADSGA--TPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETA 298
           V A+  A    D++A DLLSQAEH   +Q I +T +A   + VA  +E+ LAELP+A+ A
Sbjct: 241 VYAEGEAQDRADWLAMDLLSQAEHDRIAQAIFVTTSAQQLKEVAIEIEKALAELPKADIA 300

Query: 299 RQALNA-SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPES 357
           R +L     LI+ +D  + + + N+  PEHL +   +   L++SI  AG++F+G  +PE+
Sbjct: 301 RDSLKNRGVLILVRDREEGMAVINRVAPEHLELSVDHPDALLNSIRHAGAIFMGRHTPEA 360

Query: 358 AGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLT 417
            GDY +G NHVLPT G     S LG+ DFQK+ ++   S+ G   LA T + LA  E L 
Sbjct: 361 IGDYCAGPNHVLPTSGTARFSSPLGVYDFQKKSSIIYCSESGSKPLAQTADILAQHEDLE 420

Query: 418 AHKNAVTLRVN 428
           AH  +   R  
Sbjct: 421 AHARSARYRYQ 431


>UniRef50_A9A0A6 Histidinol dehydrogenase n=2 Tax=Desulfobacteraceae
           RepID=A9A0A6_DESOH
          Length = 434

 Score =  523 bits (1348), Expect = e-147,   Method: Composition-based stats.
 Identities = 163/436 (37%), Positives = 248/436 (56%), Gaps = 13/436 (2%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
             I    +  A+++   ++   +  +      V  I+ +VK  GD+AL  Y+ +FD   +
Sbjct: 1   MKIYTSGTPEADRRLDRIINRGLDYTPEQLHQVAAIVADVKKNGDKALERYTRQFDAPKL 60

Query: 64  TA--LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVT 121
            A   +V+A E+A A++ +     +A+  A+  +  FH          E +PGV   +  
Sbjct: 61  AASGFRVTAAEMAGAAKEVDRSFVKAINRAIGQVSEFHAMGLEKTWTAEPRPGVVVGKKV 120

Query: 122 RPVASVGLYIPG---GSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQ 174
            PV S G+Y+PG   G  PL STVLM A PA  AG +++V+ +PP     +   +L AA+
Sbjct: 121 TPVDSAGIYVPGATGGRTPLVSTVLMGAIPAKTAGVRRIVMVTPPRQDGTVNPHLLVAAK 180

Query: 175 LCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPA 234
             GV +++ VG A AIAALA GT+++ +VD I GPGN +V  AK+ V+  +    IDM A
Sbjct: 181 KVGVHEIYKVGSAWAIAALAHGTKTIARVDMIAGPGNIYVALAKKIVAGTV---GIDMMA 237

Query: 235 GPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPR 294
           GPSE+LV+AD  A P ++A+DLLSQAEH   S  +L+T +  +AR V++ V+RQ   + R
Sbjct: 238 GPSEILVVADGSADPRYIAADLLSQAEHDALSAAVLVTTSMKVARAVSDEVKRQTTGISR 297

Query: 295 AETARQALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDW 353
            + AR+AL     + V K   +   + N++ PEHL + T+N  + +D I +AG+VFLG +
Sbjct: 298 WQIARKALAAYGAVFVVKSKKEAFALVNRFAPEHLELHTKNPEKDLDQIRNAGAVFLGPY 357

Query: 354 SPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAA 413
           +PE  GDY +G NH LPT G     S+L  A F KR ++   SK  F + A+ +  +AA 
Sbjct: 358 TPEPIGDYVAGPNHTLPTSGCARFASALSTAHFLKRTSIVSYSKAAFLSEAADVMRIAAV 417

Query: 414 ERLTAHKNAVTLRVNA 429
           E L AH NAV +R+  
Sbjct: 418 EGLDAHANAVGVRLEE 433


>UniRef50_Q9X0D1 Histidinol dehydrogenase n=6 Tax=Thermotogaceae RepID=HISX_THEMA
          Length = 428

 Score =  522 bits (1346), Expect = e-147,   Method: Composition-based stats.
 Identities = 154/430 (35%), Positives = 248/430 (57%), Gaps = 15/430 (3%)

Query: 10  NSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDK--TTVTALK 67
           N+   ++  +LL +   S S  +  TV +I+  VK  GD AL E+  +F+K    +  L+
Sbjct: 5   NNPGDKEVLRLLKQRMESVS-QVEETVKEIIRRVKEEGDRALEEFLKRFEKHPVGIENLR 63

Query: 68  VSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASV 127
           V+ +EI+ A  ++ +E  + + + +++++ FH  Q+       T+ G    ++  P+ SV
Sbjct: 64  VTEKEISEA--QVEEEFVETIKIVIEDLKEFHRRQEERSFFFTTKGGSFLGEMVVPLESV 121

Query: 128 GLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQDVFN 183
           G+Y+PGG  P FST+LM A PA +AG +++ + +PP     I+  IL   ++ G+++++ 
Sbjct: 122 GIYVPGGKVPYFSTLLMCAVPAIVAGVERIAVTTPPNENGGISPYILKTCEILGLKEIYR 181

Query: 184 VGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIA 243
           +GGA A+AAL +GTE+V  VDKI GPG  FVT AK+ V   +    ID  AGPSE+ ++ 
Sbjct: 182 MGGAHAVAALTYGTETVKPVDKIVGPGGVFVTLAKKHVYGDV---GIDSIAGPSEIAIVT 238

Query: 244 DSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELP--RAETARQA 301
           D  A  D +A+D LSQAEH  ++  +++T + ++  ++ + +ER L  LP  R +TAR +
Sbjct: 239 DGSADLDLIAADFLSQAEHDENAMSVVITTSKEVFEKLPQVIERHLEALPEERRKTARIS 298

Query: 302 LNA-SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGD 360
                 +I+T  L +  EISN   PEHL +   N  E +  I +AGSVFLG ++ ES GD
Sbjct: 299 TENFGTIILTDSLKRAFEISNLIAPEHLEVLVENPFEPLGHIKNAGSVFLGKYTCESVGD 358

Query: 361 YASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHK 420
           Y +G NHVLPT+      S L ++DF K++ +  LS+E F   +     +A  E   AH 
Sbjct: 359 YGAGPNHVLPTFRSARFSSGLRVSDFTKKIFITHLSEEDFRRKSELYSKMARWEGFEAHA 418

Query: 421 NAVTLRVNAL 430
            A+ +R   L
Sbjct: 419 RAIDVRREKL 428


>UniRef50_B9KYT3 Histidinol dehydrogenase n=1 Tax=Thermomicrobium roseum DSM 5159
           RepID=B9KYT3_THERP
          Length = 448

 Score =  521 bits (1342), Expect = e-146,   Method: Composition-based stats.
 Identities = 162/414 (39%), Positives = 238/414 (57%), Gaps = 9/414 (2%)

Query: 23  RPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSD 82
           R       +  + V  I+D+V+++GD+A+R Y+  FD   +     + EE   A   ++ 
Sbjct: 37  RAVFGGDLTPLQVVERIIDDVRSQGDDAVRRYTLAFDGAHLDTFLATPEEFLRARRAITP 96

Query: 83  ELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTV 142
           EL+ A+  A   I  FH            + G    Q+ RPV  VG+Y+PGG APL S++
Sbjct: 97  ELEAALRFARDRIVAFHRRAIPRSWIEFDETGAF-GQLVRPVDRVGIYVPGGRAPLPSSL 155

Query: 143 LMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQDVFNVGGAQAIAALAFGTE 198
           LM A PA +AG + +V+C+PP     I+  +L AA+L G++ VF +GGAQAIAALA+GT+
Sbjct: 156 LMTAIPAQLAGVRDIVVCTPPGRDGTISPAVLAAAELLGIERVFKIGGAQAIAALAYGTQ 215

Query: 199 SVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLS 258
           +VP VD + GPGN FV  AKR V   +    ID   GP+E L+IAD  A P   A+DLL+
Sbjct: 216 TVPAVDIVAGPGNLFVVLAKRLVYGDV---GIDQLPGPTETLLIADEQADPVLCAADLLA 272

Query: 259 QAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALN-ASRLIVTKDLAQCV 317
           QAEH P +  IL+TPA  +A +VA+ +ERQL +L R+E AR AL     +I+  DL +  
Sbjct: 273 QAEHDPLACAILITPARTLAHKVAQELERQLQQLDRSEIARAALEANGAIIIVPDLERAF 332

Query: 318 EISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTAT 377
           +++N + PEHL +  R+    +D +  AG VFLG+ SPE  GDY +G +HV+PT      
Sbjct: 333 DLANLFAPEHLCLLVRDPWRYLDRVRHAGGVFLGETSPEVIGDYTAGPSHVMPTGRTARF 392

Query: 378 CSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNALK 431
            S + +  F K  ++  ++ +    L S    LA +E LTAH  A+  R+   +
Sbjct: 393 ASPVTVQTFLKVTSLVAVAPKALEQLGSPALQLAMSEGLTAHAAAIEHRLERTR 446


>UniRef50_Q9P777 Histidinol dehydrogenase n=71 Tax=cellular organisms
           RepID=HISX_SCHPO
          Length = 439

 Score =  518 bits (1335), Expect = e-145,   Method: Composition-based stats.
 Identities = 193/427 (45%), Positives = 267/427 (62%), Gaps = 9/427 (2%)

Query: 7   IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTAL 66
               + TAE++ +LL RP  + ++ I   V  I+++VK+RG+ +L +Y++KF+K  + + 
Sbjct: 11  YRAAALTAEERTRLLARPIQN-TQKIRTIVQPIIEDVKSRGEASLIDYASKFEKVQLKS- 68

Query: 67  KVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVAS 126
            V          ++S  +K+ + +A  NI  FH++Q  P + V+T  GV CQ+++RP+  
Sbjct: 69  AVLKAPFDDDLMKISPMIKEDIDIAFNNIFAFHSSQLRPTIAVQTMRGVVCQRMSRPINR 128

Query: 127 VGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSP----PPIADEILYAAQLCGVQDVF 182
           VGLYIPGG+A L ST LML  PA +AGC  VV+ +P      +A EI+Y A   G + + 
Sbjct: 129 VGLYIPGGTAVLPSTALMLGVPAKVAGCPHVVISTPVRKDGTVAPEIVYIANKIGAEAII 188

Query: 183 NVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDG-AAIDMPAGPSEVLV 241
             GGAQAIAA+A+G   VPKV+KIFGPGN FVT AK  V        AID+PAGPSEVLV
Sbjct: 189 LAGGAQAIAAMAYGISGVPKVNKIFGPGNQFVTAAKMHVQNDYGALVAIDLPAGPSEVLV 248

Query: 242 IADSGATPDFVASDLLSQAEHGPDSQVILLTPA--ADMARRVAEAVERQLAELPRAETAR 299
           IAD    P+ VA DLLSQAEHG DSQ+ILLT +   +M  R+ +A+      L R+   +
Sbjct: 249 IADETCNPESVALDLLSQAEHGLDSQIILLTVSLSPEMFDRIQKAINDHALRLSRSYIIK 308

Query: 300 QALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAG 359
            A+  S ++   ++ Q  E SN YGPEHL++  +NA   +  I +AGSVF+G WSP S G
Sbjct: 309 HAIKKSVIVQVDNVDQAFEWSNLYGPEHLVLHLKNASSYIPKIDNAGSVFVGPWSPVSMG 368

Query: 360 DYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAH 419
           DYASGTNH LPTYGY ++ S +    F K +T QEL++EG   L  T+  LA  E LTAH
Sbjct: 369 DYASGTNHTLPTYGYASSYSGVSTDSFLKYITTQELTEEGIQRLGPTVIRLAELEGLTAH 428

Query: 420 KNAVTLR 426
            +AV +R
Sbjct: 429 ADAVRVR 435


>UniRef50_Q3B5E3 Histidinol dehydrogenase n=8 Tax=Chlorobiaceae RepID=HISX_PELLD
          Length = 443

 Score =  517 bits (1332), Expect = e-145,   Method: Composition-based stats.
 Identities = 152/434 (35%), Positives = 234/434 (53%), Gaps = 10/434 (2%)

Query: 1   MSFNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDK 60
           ++   +  +     +   + + R ++     + R V DIL+ V+ RGD A+ EY+ +F  
Sbjct: 14  VAVLKLYRFLD-DRDALFRQIGR-SVDFDPEVQRAVTDILEAVRLRGDMAVLEYTERFQG 71

Query: 61  TTVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQV 120
             +T+++V  E+I  A E       + +  A +NI  FH  +       E + GV   Q 
Sbjct: 72  AVLTSMQVPEEDILRAREEADPAFIRVLEEAWENILRFHRHEVENSFFYEGEGGVVLGQR 131

Query: 121 TRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSP----PPIADEILYAAQLC 176
             P+    LY+PGG A   S+VLM A PA +AG  ++ + +P      ++  IL AA + 
Sbjct: 132 VTPMDRAMLYVPGGKASYPSSVLMNAAPARVAGVGEIFMTTPCDASGAVSPHILAAASVA 191

Query: 177 GVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGP 236
           GV  V+ +GGAQA+AA A+GT+++PKVD I GPGN +V  AK+QV   +   AID  AGP
Sbjct: 192 GVTSVYRLGGAQAVAAFAYGTQTIPKVDIITGPGNKYVALAKKQVFGHV---AIDSIAGP 248

Query: 237 SEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAE 296
           SEV+V+AD  A  +F+  DL +QAEH PD+  +L+TP+  +A  V +    ++  + R E
Sbjct: 249 SEVVVVADDDADAEFITMDLFAQAEHDPDASSVLITPSMRLAEEVRDLAAARVGSMLRGE 308

Query: 297 TARQAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSP 355
              +AL N   ++V  D+ +   +S+   PEHL +   +  EL+ SI  AG+VF+G +S 
Sbjct: 309 VIAEALSNNGAIVVVADIEEACRVSDMIAPEHLELHVLHPWELLASIRHAGAVFMGGYSC 368

Query: 356 ESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAER 415
           E+ GDY +G NH LPT G     S L + DF K  ++   ++    A    I + A  E 
Sbjct: 369 ETVGDYYAGPNHTLPTNGTARFFSPLSVRDFVKHTSIISYTRRQIMACGERIASFADHEG 428

Query: 416 LTAHKNAVTLRVNA 429
           L AH  AV  R+  
Sbjct: 429 LEAHAEAVRARLKK 442


>UniRef50_Q4P7D9 Putative uncharacterized protein n=3 Tax=Eukaryota
           RepID=Q4P7D9_USTMA
          Length = 896

 Score =  515 bits (1327), Expect = e-144,   Method: Composition-based stats.
 Identities = 206/463 (44%), Positives = 276/463 (59%), Gaps = 36/463 (7%)

Query: 4   NTI--IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKT 61
             I    +   +A Q+++LL RPA+  +E +      IL +VK RGD AL E + KFDK 
Sbjct: 436 IKIQSYRYEDLSAAQRKELLKRPALR-TEQVMDICRPILRSVKERGDAALLELTEKFDKA 494

Query: 62  TVTA-LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLP--------------- 105
            +T  +++      +   ++  E+K A+ +A  NI  FH AQK                 
Sbjct: 495 KLTNAVRLPPFVDDSVMAQIKPEVKVAIDIAYNNIYKFHKAQKTTFGNKSAGATGSGSAD 554

Query: 106 --------PVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKV 157
                    ++VET PGV C++  RP+ SVGLY+PGGSA L ST LML  PA +A C  V
Sbjct: 555 GSEGAQDGVLEVETMPGVVCRRFARPIESVGLYVPGGSAVLPSTALMLGVPAQVARCPTV 614

Query: 158 VLCSPP----PIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAF 213
           V+ +PP     I+ E+LY A       +   GGAQA+AALA+GTES PKVDKI GPGN F
Sbjct: 615 VIATPPRADGSISPEVLYCASKVNASAILCAGGAQAVAALAYGTESCPKVDKIVGPGNQF 674

Query: 214 VTEAKRQVSQRLDG-AAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILL- 271
           VT AK  V    D   +IDMPAGPSEVLVIAD  A   FVASDLLSQAEHGPDSQV+L+ 
Sbjct: 675 VTAAKMLVQNETDAIVSIDMPAGPSEVLVIADREADAAFVASDLLSQAEHGPDSQVVLVG 734

Query: 272 --TPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQCVEISNQYGPEHLI 329
               ++++A  +   V+RQ   LPR +  RQA++ S  ++  D A  +E SN Y PEHLI
Sbjct: 735 IALSSSELA-AIEAEVDRQARALPRVDVVRQAIDKSVTVIVPDRATAMEWSNAYAPEHLI 793

Query: 330 IQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKR 389
           +QTR+A  LV+ + +AGS+F+G WSPES GDY SGTNH LPT  Y  + S + +A F+K 
Sbjct: 794 LQTRDAESLVECVQNAGSIFVGPWSPESCGDYMSGTNHSLPTAAYAKSYSGVNVATFEKC 853

Query: 390 MTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNALKE 432
           +T Q L+++G    A  +  LA  E L AH  AV +R++ ++ 
Sbjct: 854 ITSQSLTQQGLKGFAQNVIDLAMCEGLQAHAMAVKIRLDRIQS 896


>UniRef50_Q87C29 Histidinol dehydrogenase n=66 Tax=cellular organisms
           RepID=HISX_XYLFT
          Length = 431

 Score =  515 bits (1327), Expect = e-144,   Method: Composition-based stats.
 Identities = 216/428 (50%), Positives = 281/428 (65%), Gaps = 5/428 (1%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
             IIDWN      Q + L RPA + +      V  +++ V+  GD ALR+ +A+FD   +
Sbjct: 1   MKIIDWNQLDTAAQAKTLTRPAQTIATQTREAVTALIEQVRRGGDTALRDITARFDGVDL 60

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRP 123
              +V+A E+AAA+  ++ EL+ AM  A   IE FH A       VET PGV C+++ RP
Sbjct: 61  ATFEVTAAELAAAATAVAPELQHAMQTAAARIEAFHRAGMTNDYRVETAPGVVCERLVRP 120

Query: 124 VASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPI----ADEILYAAQLCGVQ 179
           +A VGLY+P GSAPLFST LML  PA +AGC++VVLC+PP         +L AA+L GV 
Sbjct: 121 IARVGLYVPAGSAPLFSTALMLGVPARLAGCREVVLCTPPSKDGRANPAVLLAARLTGVT 180

Query: 180 DVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEV 239
            VF +GGAQAIAA+A+GT SVP  DK+FGPGN+FVTEAK+Q++ +    AIDMPAGPSEV
Sbjct: 181 RVFTLGGAQAIAAMAYGTASVPTCDKVFGPGNSFVTEAKQQLA-QAGVVAIDMPAGPSEV 239

Query: 240 LVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETAR 299
           LVIAD+ A P F+A+DLLSQAEHGPDSQV+LL+ +  +   V  A+  QL +L RAE AR
Sbjct: 240 LVIADAAANPAFIAADLLSQAEHGPDSQVLLLSDSDALMTAVQNALALQLQQLSRAEIAR 299

Query: 300 QALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAG 359
           QAL  SR I    L    +ISN+Y PEHLI+  R  R  +  + +AGSVFLGD++PE+ G
Sbjct: 300 QALAHSRFIKVATLETAFDISNRYAPEHLILALRQPRAWLHRVAAAGSVFLGDYTPEALG 359

Query: 360 DYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAH 419
           DY SGTNHVLPT G     S + ++ FQ  ++VQ  S+ G + +     TLA AE L AH
Sbjct: 360 DYCSGTNHVLPTGGAARAYSGVSVSSFQNMISVQAASRSGIAEIGGCALTLARAEGLDAH 419

Query: 420 KNAVTLRV 427
            NAV LR+
Sbjct: 420 ANAVALRM 427


>UniRef50_Q3ZXL7 Histidinol dehydrogenase n=5 Tax=Dehalococcoides RepID=HISX_DEHSC
          Length = 436

 Score =  515 bits (1326), Expect = e-144,   Method: Composition-based stats.
 Identities = 158/422 (37%), Positives = 241/422 (57%), Gaps = 14/422 (3%)

Query: 12  CTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAE 71
               ++ +L  R  +       + VN I+ +V+ +GDEA+  Y+ KFD+  ++ L+V   
Sbjct: 24  LDETERTELARRLGVDP----EKAVNGIIADVRKQGDEAVLGYTLKFDRANLSKLEVGQP 79

Query: 72  EIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYI 131
           EI  A+  +  EL +A+ +A   I  +H  QK      +T   ++ +Q+ RP+  VGLY+
Sbjct: 80  EIQQAASEIPAELFEALQLAASQIRAYHRFQKEAVW--KTAEIMQGKQLIRPLERVGLYV 137

Query: 132 PGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQDVFNVGGA 187
           PGG A   STVLM A PA  AG K+++L +PP     I    L AAQ+ GV  +F  GGA
Sbjct: 138 PGGKAFYPSTVLMTAIPAREAGVKEIILVTPPGANGKIPAPTLAAAQIAGVDRIFACGGA 197

Query: 188 QAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGA 247
           QA+AALAFGT+S+PKVDKI GPGN FVT AK+ V   +D   ID   GPSEVL++AD  A
Sbjct: 198 QAVAALAFGTKSIPKVDKICGPGNIFVTLAKKAVFGVVD---IDGLQGPSEVLIVADQYA 254

Query: 248 TPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASR 306
             ++ ASD+L+QAEH   +  IL+T + D+A RV + VE +     R +  +Q+L +   
Sbjct: 255 NAEYCASDILAQAEHDALASSILITTSEDLANRVNDIVESKADTCSRRDIIKQSLRDNGL 314

Query: 307 LIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTN 366
           + V  ++ + ++++N Y  EHL +  +++ + +  I  AG +F G+ +    GDY +G +
Sbjct: 315 IAVVDNINEAIKLANMYAAEHLCLLVKDSEKYLTQINHAGCIFYGEKASVVMGDYVAGPS 374

Query: 367 HVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
           H LPT G     S L + DF K + + ++ K+  + L     T+A AE L  H  AV  R
Sbjct: 375 HALPTSGTARFSSPLNILDFVKYIDIVKVDKQDIAKLGQAAATIAKAEGLECHAEAVLKR 434

Query: 427 VN 428
           + 
Sbjct: 435 LE 436


>UniRef50_B3DXR9 Histidinol dehydrogenase n=1 Tax=Methylacidiphilum infernorum V4
           RepID=B3DXR9_METI4
          Length = 426

 Score =  513 bits (1321), Expect = e-144,   Method: Composition-based stats.
 Identities = 150/430 (34%), Positives = 251/430 (58%), Gaps = 8/430 (1%)

Query: 1   MSFNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDK 60
           M    I+ +     +Q+++ L R  +  S+ I +TV  +L+ +   GD+A+  Y+ +FDK
Sbjct: 3   MIDFKILRFGDLNWQQEKKGLSRFYL-PSKEIEQTVRRVLEEIIRNGDKAVSLYTEQFDK 61

Query: 61  TTVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQV 120
            +++     A  I   + +   ++  A+  A +NI  F  A K     +  + G R  + 
Sbjct: 62  QSISP---GAFRITEKAPQPPKDVVDALRWAKRNILCFAKANKPKNWSITNREGARVGEY 118

Query: 121 TRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQD 180
             P   +G+Y+PGG+APL ST LM    A  AG K++V+CSPPP+   + ++    G  +
Sbjct: 119 YTPFRRIGVYVPGGTAPLISTALMTVCFAKAAGVKEIVVCSPPPVNPILHFSIIYSGATE 178

Query: 181 VFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVL 240
           ++ +GG QAI ALA+GTES+PKV+KIFGPGNA+V EAKRQV   +   +ID+  GPSE+ 
Sbjct: 179 IYRIGGIQAIGALAYGTESIPKVEKIFGPGNAYVVEAKRQVIGPV---SIDLLPGPSEIA 235

Query: 241 VIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQ 300
           V A   A P+F+A+DLL+QAEHGP S+++ ++P   +   V  A+ RQL  L R +  ++
Sbjct: 236 VFASWPANPEFIAADLLAQAEHGPSSKILFVSPENSLLESVIGAINRQLPSLKRQQILKE 295

Query: 301 AL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAG 359
            L + +  +  + + + + + N + PEHL +Q   A++ +    + G+++LG +S  +AG
Sbjct: 296 VLTDHAYFVQVRSIDEGIGLINDFAPEHLSLQIPGAKKYLAQFKNCGAIYLGPYSAVAAG 355

Query: 360 DYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAH 419
           D+ +G +H LPT G   + S L ++ F ++ +V E SK+    ++S +ET A  E L AH
Sbjct: 356 DFLAGPSHTLPTGGAAKSFSGLTMSHFYRKTSVVEYSKKALCRVSSLLETFARIESLDAH 415

Query: 420 KNAVTLRVNA 429
             ++T+R  +
Sbjct: 416 GASITIRKES 425


>UniRef50_A5D1M4 Histidinol dehydrogenase n=1 Tax=Pelotomaculum thermopropionicum SI
           RepID=A5D1M4_PELTS
          Length = 437

 Score =  511 bits (1316), Expect = e-143,   Method: Composition-based stats.
 Identities = 153/440 (34%), Positives = 238/440 (54%), Gaps = 14/440 (3%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
           +  +      +AE   +++ R  +    S+   V  ++ +VK+RGD+AL +Y+ +FD  T
Sbjct: 2   YIQVFRLKEMSAEDYNRIMKRSEVETD-SVIGEVKKVIADVKSRGDDALVDYTREFDGIT 60

Query: 63  VT--ALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPP-VDVETQPGVRCQQ 119
           ++   ++VS EEI  A  ++  E  +A+     N+  FH AQ       +E  PG+   Q
Sbjct: 61  ISAEKIRVSPEEIKEAYHKVDRETVEAIKTLAGNVRRFHAAQMPNKMWSMEVSPGLVAGQ 120

Query: 120 VTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSP----PPIADEILYAAQL 175
           V  P+  VG Y+PGG     S V+M   PA +AG  +V++C+P      +    L A  +
Sbjct: 121 VIIPLDRVGCYVPGGRGWFPSAVMMSVLPARVAGVPEVIVCTPSAPDGSVPPGTLVACDI 180

Query: 176 CGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAG 235
           CG   VF +GG+QA+AA+A+GT++VPKVDKI GPG+ +V  A + +   ++   I   AG
Sbjct: 181 CGADAVFRIGGSQAVAAMAYGTQTVPKVDKIVGPGSKWVLAAFKLLYGEVE---IGTHAG 237

Query: 236 PSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELP-- 293
           P E L+IAD  A P+F A+D+  QAEHG DS  +L+T   ++A  V + + R +  L   
Sbjct: 238 PGEGLIIADETADPEFAAADICIQAEHGLDSAGVLVTHVEELAWAVQKKIARHIERLNEY 297

Query: 294 RAETARQALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGD 352
           R     ++L     +I+T  L + +  +N Y  EHL I TR+   ++  I +AG ++LG 
Sbjct: 298 RKNFVVESLKKYGAIIITSSLEESIAFANDYAVEHLEIMTRDPLHVMQKIKNAGGIYLGH 357

Query: 353 WSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAA 412
           ++P S G + SG NHVLPT         L  ADF K +T + LS+EG ++L   +  LA 
Sbjct: 358 YTPLSCGCFGSGPNHVLPTGRKAKVSGGLKTADFYKAVTFEYLSREGLASLKDAMVKLAE 417

Query: 413 AERLTAHKNAVTLRVNALKE 432
            E   AH NA+  R    + 
Sbjct: 418 YEGFPAHGNAILERFAREQS 437


>UniRef50_A3EUM9 Histidinol dehydrogenase n=3 Tax=Leptospirillum RepID=A3EUM9_9BACT
          Length = 445

 Score =  510 bits (1315), Expect = e-143,   Method: Composition-based stats.
 Identities = 156/422 (36%), Positives = 239/422 (56%), Gaps = 11/422 (2%)

Query: 20  LLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT--VTALKVSAEEIAAAS 77
           +  R   S  E++   V+ IL +++  GD AL  Y+ + D     +  L+VS   +  + 
Sbjct: 24  IFQRGRDSEGETLRARVSSILGDIRREGDVALLRYARELDGFRGELKDLRVSPGRMEESF 83

Query: 78  ERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAP 137
             L  E+++A+  A   IE FH A +   +        +   + RP+  VG+Y+PGG+A 
Sbjct: 84  GALPSEIRKALVFAKDRIEEFHGALREKGLSGLASRPGKGGVLVRPLHRVGVYVPGGTAA 143

Query: 138 LFSTVLMLATPASIAGCKKVVLCSP---PPIADEILYAAQLCGVQDVFNVGGAQAIAALA 194
             STVLM A  A +AG K++V  SP     I D IL A  +CGVQDV+ VGG  AIAA+A
Sbjct: 144 YPSTVLMTAVVAKVAGVKQIVGVSPAGPGGIPDAILAAFHVCGVQDVYQVGGVHAIAAMA 203

Query: 195 FGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVAS 254
           +GT ++P+VDKI GPGN +V EAKRQV   +D   IDM AGP+E+L++AD  A P+++A+
Sbjct: 204 YGTGTIPRVDKIVGPGNRYVAEAKRQVFGDVD---IDMVAGPTEILILADDSARPEWLAA 260

Query: 255 DLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDL 313
           D+++QAEH   +  +L+     +A+ V  A+ERQ++ LPR + A ++L     ++V   +
Sbjct: 261 DMIAQAEHDTRASAVLILTDMTLAKAVVLALERQISSLPRQKIAEESLLKYGFILVVPSV 320

Query: 314 AQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYG 373
              VEIS+   PEHL +Q RN  + +  I +AG+VFLG    E+ GDY  G +HVLPT G
Sbjct: 321 QVAVEISDLVAPEHLELQVRNPEKWLGLIQNAGAVFLGSEMAEAFGDYCFGPSHVLPTNG 380

Query: 374 YTATCSSLGLADFQKRMTVQE--LSKEGFSALASTIETLAAAERLTAHKNAVTLRVNALK 431
                S + +  F KR ++ E   S++    +      LA  E L  H  +   R+  ++
Sbjct: 381 SARFSSPVSIETFTKRTSLLEGFRSRQELEDVVRNSALLARLEGLEGHARSALARLENVQ 440

Query: 432 EQ 433
           ++
Sbjct: 441 KE 442


>UniRef50_C7NG13 Histidinol dehydrogenase n=2 Tax=Bacteria RepID=C7NG13_KYTSD
          Length = 439

 Score =  510 bits (1315), Expect = e-143,   Method: Composition-based stats.
 Identities = 218/435 (50%), Positives = 285/435 (65%), Gaps = 4/435 (0%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
             ++DWN+    ++   L RPA +  E +T  V ++LD V+ARG +A+  Y+ +FD    
Sbjct: 1   MRVLDWNALDDSERTAALERPAQAVGEQVTAAVAEVLDAVRARGADAVVGYTERFDGVGR 60

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRP 123
             L +S  EI  A E++ D ++ A+A A   + TFH    L P  V+T PG+RC+++ RP
Sbjct: 61  EHLLLSEAEIDRAVEQVPDAVRAAIAQAAATLRTFHAPGALSPFAVDTAPGMRCERIVRP 120

Query: 124 VASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPI----ADEILYAAQLCGVQ 179
           V +VGLY+P GSAPL ST LML  PA +AGC +VV+C+PP         ++ A    G++
Sbjct: 121 VRTVGLYVPAGSAPLPSTALMLGVPAVLAGCPEVVVCTPPTAQGTADPSVVAACVEVGIR 180

Query: 180 DVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEV 239
            +  VGGAQA+ A+AFG   +P+ DKIFGPGN+FVTEAKRQV+    G  ID+PAGPSE 
Sbjct: 181 RIAVVGGAQAVGAMAFGAGPIPRCDKIFGPGNSFVTEAKRQVAGMQGGPGIDLPAGPSEQ 240

Query: 240 LVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETAR 299
           LVIAD+GA P +VA+DLLSQAEHGPDSQV+ ++   D+  +VA  VERQ AELPRA+   
Sbjct: 241 LVIADAGANPVWVAADLLSQAEHGPDSQVVCVSDDRDLLEQVAAEVERQAAELPRAQIVA 300

Query: 300 QALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAG 359
            AL ASRL++  DL Q V +SN Y PEHLI+  R  REL+  IT+AGS+FLGD +PES G
Sbjct: 301 GALTASRLVLVDDLDQAVAVSNAYAPEHLILAVRAPRELLAGITAAGSIFLGDHTPESLG 360

Query: 360 DYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAH 419
           DY SGTNHVLPT G       + LA FQ  +TVQE S    + L +T  TLA AE L AH
Sbjct: 361 DYCSGTNHVLPTSGAARYTGGVNLASFQLSITVQEASPRALAQLGATAVTLARAEGLEAH 420

Query: 420 KNAVTLRVNALKEQA 434
             AVT RV+A +  A
Sbjct: 421 ARAVTRRVDASEAAA 435


>UniRef50_C8WUX6 Histidinol dehydrogenase n=2 Tax=Alicyclobacillus acidocaldarius
           RepID=C8WUX6_ALIAD
          Length = 426

 Score =  506 bits (1305), Expect = e-142,   Method: Composition-based stats.
 Identities = 171/430 (39%), Positives = 245/430 (56%), Gaps = 9/430 (2%)

Query: 7   IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTAL 66
           +  +     +Q     R        +   V  I++ V+  GD+ALR  +   D      L
Sbjct: 1   MRLDRVDVIEQASFNWRRTTGRDADVWEKVERIVEEVRVGGDDALRRLTRALDGVD-APL 59

Query: 67  KVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVAS 126
           +V  E + AA   L  E+++A+A A + I  FH AQ    + +  + G   + + RP+  
Sbjct: 60  RVPPEAMEAAFRALRAEVREALARAAERIRRFHEAQLPNDIVIRGEDGETLEMLWRPLHR 119

Query: 127 VGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPI----ADEILYAAQLCGVQDVF 182
           VG+Y PGG A   STVLM   PA +AG + + L SPP         +L AA L GV++++
Sbjct: 120 VGVYAPGGRAAYPSTVLMDVIPAQVAGVRSIALVSPPGPDGLPHPAVLAAAHLVGVEEMY 179

Query: 183 NVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVI 242
            VGGAQA+AALA+GTE++ +VDKI GPGN +V  AKR V   +    ID  AGP+EV+V+
Sbjct: 180 AVGGAQAVAALAYGTETIARVDKIVGPGNVYVATAKRMVMGDV---GIDSIAGPTEVVVV 236

Query: 243 ADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL 302
           AD  A P +VA+DLL+QAEH  ++  + L+P+ ++   V   + RQLA LPR + AR+AL
Sbjct: 237 ADETANPAYVAADLLAQAEHDVEAGAVCLSPSRELLENVHAEIVRQLAALPRRDIAREAL 296

Query: 303 N-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDY 361
                L+  K L   V + N   PEH+ + T N R +++ + +AG+VFLG ++PE  GDY
Sbjct: 297 ERHGALVHVKSLDDAVVLVNDMAPEHVEVVTENPRRVLNGLRTAGAVFLGPYTPEPVGDY 356

Query: 362 ASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKN 421
            +GTNHVLPT+G     S LG  DF +RMT    + E  +  A  IE LA AE LTAH+ 
Sbjct: 357 FAGTNHVLPTHGSARFSSGLGTLDFMRRMTAATYTAETIARHAPYIEALAEAESLTAHRE 416

Query: 422 AVTLRVNALK 431
           AV +R   L+
Sbjct: 417 AVRIRREELR 426


>UniRef50_P62460 Histidinol dehydrogenase n=15 Tax=Bacteria RepID=HISX_THET2
          Length = 412

 Score =  506 bits (1303), Expect = e-142,   Method: Composition-based stats.
 Identities = 172/414 (41%), Positives = 241/414 (58%), Gaps = 6/414 (1%)

Query: 14  AEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEI 73
           AE+ R    R  +S   ++   V  IL+ V+  GDEAL  +S   D   V   +V     
Sbjct: 5   AEEVRARFARRGLSFDPTVEEIVRGILEAVREEGDEALDRFSRDLDGYPVE--EVPKRAW 62

Query: 74  AAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPG 133
             A E L ++L+ A+  A + IE F+  +      +  + G    Q+ RP+  VG+Y+PG
Sbjct: 63  REAYEDLDEDLRDALETARERIEAFYREEARGGF-LRAEGGGVLAQLVRPLERVGVYVPG 121

Query: 134 GSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVFNVGGAQAIAAL 193
           GSAPL ST+LM   PA +AG ++V++ SPP +   +L AA + G   +F +GGAQAIAAL
Sbjct: 122 GSAPLLSTLLMTVVPAKVAGVREVIVASPPKVHPGVLAAAWVAGADRLFAMGGAQAIAAL 181

Query: 194 AFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVA 253
           A+GT  VP+VDKI GPGN +V  AKR V   +    ID  AGP+E ++IAD  A+P  +A
Sbjct: 182 AYGTGRVPRVDKIVGPGNRYVVAAKRLVYGTV---GIDGLAGPTETMIIADGSASPRLLA 238

Query: 254 SDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDL 313
           +DLL+QAEHGPDS+  LL+P   +  RV   + RQL +LPRAE ARQAL    L++TKDL
Sbjct: 239 ADLLAQAEHGPDSEPWLLSPDRALLERVEAELSRQLQDLPRAEVARQALEKGGLVLTKDL 298

Query: 314 AQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYG 373
            +   ++N Y PEHL +   +    ++ + +AG VFLG+ SPE+ GDY +G +HV+PT G
Sbjct: 299 EEAFALANLYAPEHLSLALSDPLPWLEKVQNAGGVFLGEGSPEALGDYIAGPSHVMPTSG 358

Query: 374 YTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRV 427
                  L + DF K + V  LS+     LA     LA AE L  H  ++ LR 
Sbjct: 359 TARFQGGLAVRDFLKVIPVVGLSEGAARELAKKGALLARAEGLEGHARSLDLRR 412


>UniRef50_Q4A044 Histidinol dehydrogenase n=62 Tax=Staphylococcus RepID=HISX_STAS1
          Length = 423

 Score =  501 bits (1291), Expect = e-140,   Method: Composition-based stats.
 Identities = 142/408 (34%), Positives = 234/408 (57%), Gaps = 11/408 (2%)

Query: 26  ISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELK 85
            S +E +   V DI +NV+  GD+ALR Y+ +FD+     L+V+ + +  A  RL  +L+
Sbjct: 16  SSLNEDLYPIVKDICENVRLHGDDALRNYNQQFDQVETCNLEVAYQTLENAYNRLDSDLR 75

Query: 86  QAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLML 145
           +A+  +   I+++  + K      + Q    C ++  P+  VG+Y+PGG A   STVLM 
Sbjct: 76  EALQQSHARIQSYQESIK----WTKQQGTSDCYELYHPLERVGVYVPGGKASYPSTVLMT 131

Query: 146 ATPASIAGCKKVVLCSPP---PIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPK 202
            T A +AG K + + +PP    I D +L A  + GV +V+ VGGAQ+IAALA+GTE++PK
Sbjct: 132 VTLAKVAGVKNISVVTPPQLNGIPDIVLAACYIAGVDNVYQVGGAQSIAALAYGTETLPK 191

Query: 203 VDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEH 262
           VDKI GPGN FV  AK+ +  ++    ID  AGPSE+ +I D  A  D +A D+ +QAEH
Sbjct: 192 VDKIVGPGNQFVAYAKKYLFGQV---GIDQIAGPSEIALIIDDSADLDAIAYDVFAQAEH 248

Query: 263 GPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVEISN 321
              ++  +++    + +++ + ++  L ++ R    + +L +   LI   + ++  ++ N
Sbjct: 249 DELARTFVISEDEALLKQLEQKIQHILPQIERQSIVQASLNDNHFLIHVNNFSEACDLMN 308

Query: 322 QYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSL 381
           Q  PEH  IQT +  + ++ +   G++FLG +SPE  GDY +G +HVLPT       + L
Sbjct: 309 QIAPEHASIQTVSPHDYLNHVRYVGALFLGYYSPEVIGDYVAGPSHVLPTNQTARFTNGL 368

Query: 382 GLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNA 429
            + DF  R +V +LSK+ F  +  T   LA  E+L  H+ ++ +R + 
Sbjct: 369 SVNDFLTRHSVIDLSKDTFDTVELTARKLAHVEQLYNHEQSIEIRTSK 416


>UniRef50_Q4FNE2 Histidinol dehydrogenase 1 n=3 Tax=Candidatus Pelagibacter
           RepID=HISX1_PELUB
          Length = 428

 Score =  501 bits (1291), Expect = e-140,   Method: Composition-based stats.
 Identities = 144/431 (33%), Positives = 244/431 (56%), Gaps = 8/431 (1%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              I+D  +   ++    L+    +  +  + +V  I+ +VK  GD+A+ +Y  +F+K +
Sbjct: 1   MIKILDSKNKNFDKTLDALLSKRKNKVQLNSVSVIKIIKDVKKNGDKAILKYEKRFNKNS 60

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
           +  +  S ++I  A + L  ++K+A+ +A   I  FH+ QK   +    +   + +    
Sbjct: 61  I--IAPSIKQINRAIQSLDQKVKKAIDLAYDRIYKFHSLQKFKNISYTDKLKNKLEYKYV 118

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPI---ADEILYAAQLCGVQ 179
           P+ SV +Y+PG +A   S+VLM A PA +AG K++V+ +P         +LYAA+ C ++
Sbjct: 119 PIESVAIYVPGSTASYPSSVLMNAVPAIVAGVKRLVMVNPGQKGKQNPAVLYAAKKCKIK 178

Query: 180 DVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEV 239
           +++++GG  AIAA+A+GT+ + KVDKI GPGN++V  AK++V   +      M AGPSEV
Sbjct: 179 EIYSIGGPSAIAAVAYGTKKIKKVDKIIGPGNSYVAAAKKEVFGDVGIEG--MIAGPSEV 236

Query: 240 LVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETAR 299
            ++ D  + P+++ASDL+ QAEH   +Q IL++    + ++V   +  QL ELPRA  A+
Sbjct: 237 TIVCDKFSNPEWIASDLIGQAEHDNLAQCILISKDKSIIKKVNYEIINQLKELPRAVIAK 296

Query: 300 QAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESA 358
            +L N   LI      + +   N+  PEHL + T+N +++V  I +AGS+ LG ++  + 
Sbjct: 297 NSLLNNGILIYMPSDQKIINTVNKIAPEHLELNTKNYKKVVSKIKNAGSICLGKYAVMAM 356

Query: 359 GDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTA 418
            DY  G+NHVLPT       S + + +F KR++   LSK+G   L  ++ TLA  E L  
Sbjct: 357 TDYNVGSNHVLPTNSSARYSSGVSVNEFYKRISYINLSKKGIETLGPSVITLANYEGLVG 416

Query: 419 HKNAVTLRVNA 429
           H  +V  R+  
Sbjct: 417 HAKSVEKRIRR 427


>UniRef50_C9RN89 Histidinol dehydrogenase n=1 Tax=Fibrobacter succinogenes subsp.
           succinogenes S85 RepID=C9RN89_FIBSS
          Length = 429

 Score =  500 bits (1289), Expect = e-140,   Method: Composition-based stats.
 Identities = 165/434 (38%), Positives = 241/434 (55%), Gaps = 15/434 (3%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
             I+     + ++  ++  R  ++ S+ I   V DIL ++K  G     EY+ KFD    
Sbjct: 1   MKIVKVTPKS-QEIDRICGR-EVAPSKEIHDKVMDILADIKNGGYAKAVEYAQKFDGLKG 58

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRP 123
             L+VS  EI  ++ +   E+++A+  A+KN+  FH  Q      +E + GV   Q  RP
Sbjct: 59  KNLRVSEAEIKKSAAKCPPEMQRALKQAIKNVRDFHVNQMEDSWLMEGKDGVVLGQRIRP 118

Query: 124 VASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSP--PPIADEILYAAQLCGVQDV 181
           +  VGLY+PGG+    STV+M A PA +AG K +V+ +P    I   + +     G+ +V
Sbjct: 119 MKRVGLYVPGGAGIYPSTVIMNAVPAIVAGVKDIVVVTPIKGEINRAVAFVLCELGITEV 178

Query: 182 FNVGGAQAIAALAFGTES------VPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAG 235
           +++GGAQAI  LA+G +       V +VDKI GPGN F   AK++V   +D   IDM AG
Sbjct: 179 YHIGGAQAIGMLAYGAKDGKGKVVVERVDKIVGPGNVFAAVAKKEVFGIVD---IDMVAG 235

Query: 236 PSEVLVIADSGATPDFVASDLLSQAEHGPD-SQVILLTPAADMARRVAEAVERQLAELPR 294
           PSEVLV+AD+   PDFVA+DLLSQAEHG      I +T   + A+ ++E V+ Q+   P+
Sbjct: 236 PSEVLVLADNTCDPDFVAADLLSQAEHGSGFEAAICITDNMETAQMISECVDIQVENSPK 295

Query: 295 AETARQALNA-SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDW 353
            E  ++ L+   R++V KD    V I+N   PEH+ I T  A  +   I +AG+VF+G W
Sbjct: 296 RELLQKVLDNFGRILVVKDWFDGVAIANAIAPEHMEIMTDEAESMAAQIENAGAVFIGPW 355

Query: 354 SPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAA 413
           S E  GDY +G NHVLPT G     S LG+ DF KRM++ + S++     A  I  +A  
Sbjct: 356 SSEPVGDYFAGPNHVLPTNGTGRFFSPLGVYDFLKRMSIIKYSEKAIKKNAKAIAVVANE 415

Query: 414 ERLTAHKNAVTLRV 427
           E    H  AV  R+
Sbjct: 416 EGFIHHAAAVLKRL 429


>UniRef50_D0LM64 Histidinol dehydrogenase n=2 Tax=Nannocystineae RepID=D0LM64_HALO1
          Length = 438

 Score =  500 bits (1289), Expect = e-140,   Method: Composition-based stats.
 Identities = 181/440 (41%), Positives = 256/440 (58%), Gaps = 12/440 (2%)

Query: 1   MSFNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDK 60
           M    I       + + R LL R + S +  + R V DIL  V+ARGDEA+R ++ KFD 
Sbjct: 1   MILKRIPLDAGGDSRELRALLER-STSFASEVERAVADILAEVRARGDEAVRAFTEKFDG 59

Query: 61  TTV---TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVE---TQPG 114
            +    ++ ++   +   A   L+ E+  A+  A + +  FH  Q       +      G
Sbjct: 60  RSPRAGSSYEIPPGDWRRAKGELAPEVLAALEQAAERVRAFHARQAEVDRAADFSLDGGG 119

Query: 115 VRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQ 174
           +R      P++ VG+Y+PGG+A   S+VLM A PA IAG  ++++ +P   + E L AA 
Sbjct: 120 MRLDLRIDPLSRVGIYVPGGTARYPSSVLMTAIPARIAGVDEIIMVTP-GASKETLAAAA 178

Query: 175 LCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPA 234
           L GV  VF +GGAQA+AALA+GTESVP+VDKI GPGN +V  AKRQV   +D   ID  A
Sbjct: 179 LAGVDRVFEIGGAQAVAALAYGTESVPRVDKIVGPGNQWVAAAKRQVFGVVD---IDSVA 235

Query: 235 GPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPR 294
           GPSEVL++AD  A P +VA+DLL+QAEH P +  +L T +  +A  V E + RQLA+LPR
Sbjct: 236 GPSEVLILADDSANPRWVAADLLAQAEHDPLAHPVLATTSPALADAVDEELARQLADLPR 295

Query: 295 AETARQALNA-SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDW 353
           A+ AR AL      ++  D    V  +N+Y PEHL +  R  R ++  + +AG++F+G  
Sbjct: 296 ADIARTALANQGAAVLVPDQGAAVAFANRYAPEHLELHLREPRAVLGQLRTAGAIFVGAL 355

Query: 354 SPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAA 413
           + E+AGDY +G NHVLPT G     S LG+ DF+K  ++ E   E   A A  I  LAA 
Sbjct: 356 AAEAAGDYMAGPNHVLPTGGAARYASPLGVYDFRKHTSIIEYQAEAVLAQADAIAALAAV 415

Query: 414 ERLTAHKNAVTLRVNALKEQ 433
           E L AH  ++TLR +AL+  
Sbjct: 416 EGLDAHGRSMTLRRDALRAA 435


>UniRef50_B1YL14 Histidinol dehydrogenase n=1 Tax=Exiguobacterium sibiricum 255-15
           RepID=B1YL14_EXIS2
          Length = 405

 Score =  499 bits (1285), Expect = e-139,   Method: Composition-based stats.
 Identities = 161/401 (40%), Positives = 235/401 (58%), Gaps = 6/401 (1%)

Query: 27  SASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQ 86
           S      + V  IL+ V   GD A+R Y+++FD+  +T  ++   +I  A ++    L  
Sbjct: 8   SVDRETEQAVRSILEQVANDGDAAVRRYTSEFDRVDLTDFRLDETKIQEAFDQADPNLVD 67

Query: 87  AMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLA 146
           ++ +    +  +H  +    +++     V  +Q   PV SVG+Y+PGG+A   STVLM A
Sbjct: 68  SLKLMATRLVEWHEQELPSDIELVEAD-VTRRQRFVPVDSVGIYVPGGAASYPSTVLMNA 126

Query: 147 TPASIAGCKKVVLCSP-PPIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDK 205
            PA +AG ++VV+ +P   ++ E+L AA++ GV +++ +GGAQA+AAL FGTES+  VD 
Sbjct: 127 IPAKVAGVERVVMVTPVTGLSMEVLVAAKIAGVTEIYTIGGAQAVAALTFGTESIQAVDL 186

Query: 206 IFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPD 265
           I GPGN FV EAKRQV   +    ID  AGPSEV+VIAD  A PD +A+DLL+QAEH  D
Sbjct: 187 IVGPGNRFVAEAKRQVYGIV---GIDSVAGPSEVVVIADETAHPDRIAADLLAQAEHDRD 243

Query: 266 SQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQCVEISNQYGP 325
           +  I   P   M   V   +ER+L +LPR E AR+A+    + V   L   +E +N+   
Sbjct: 244 AVAIAFVPTEAMKADVDANIERRLQQLPRQEIARRAMENGGVFVA-SLDDAIEEANRLAA 302

Query: 326 EHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLAD 385
           EHL +   N +E+V  I  AG +FLG  +PE+ GDY +GTNHVLPT G     S L    
Sbjct: 303 EHLELAVANPQEVVKLIRHAGMIFLGHETPETLGDYVAGTNHVLPTSGTARFASGLSART 362

Query: 386 FQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
           F +  T+ E ++EG + LA+  +T+A  E L AH  A+ +R
Sbjct: 363 FLRHQTMLEATREGVARLANAAKTVARVEGLEAHAQAIEVR 403


>UniRef50_Q01ZU1 Histidinol dehydrogenase n=1 Tax=Candidatus Solibacter usitatus
           Ellin6076 RepID=Q01ZU1_SOLUE
          Length = 423

 Score =  497 bits (1280), Expect = e-139,   Method: Composition-based stats.
 Identities = 168/428 (39%), Positives = 248/428 (57%), Gaps = 15/428 (3%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              I++           LL R A   +E+    V  IL+ V+ RGD AL +Y+ +FD+  
Sbjct: 1   MIRILESKDVG-----HLLKRKAARFTEA-EAVVTPILEAVRKRGDRALMDYARQFDQLQ 54

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
             +++V   E+ AA + L+ E + A+  A  NI  +   Q     +     G++  Q+ R
Sbjct: 55  RKSVRVPEGELLAARDGLTPEFRGAIETAAPNIRAYAGRQMPREWNRSFGAGLQLGQLVR 114

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVF 182
           P+ +V  YIP G  PL STV+M   PA +AG   + +  P P+A E+   A + GV++VF
Sbjct: 115 PLDAVAAYIPAGRYPLPSTVMMTVIPAQVAGVPNICIACPKPVA-EVYGTAAMLGVRNVF 173

Query: 183 NVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVI 242
            +GGAQAIAA AFGT +VP+ D+I GPGN +V  AK+ ++  +    ID  AGP+E+L+I
Sbjct: 174 QMGGAQAIAAFAFGTRTVPRADRIVGPGNIYVAAAKKLLAGEV---GIDFIAGPTEILII 230

Query: 243 ADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL 302
           A +   P   A+D+L+QAEH  D+  ILLT +  +A  V+  +ERQLA LP A  A +++
Sbjct: 231 A-ADGDPRHFAADMLAQAEHDVDASAILLTTSKRLAAAVSRELERQLAILPTAPVASKSI 289

Query: 303 -NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDY 361
              S +I+ + L + +EISN++ PEHL I       L+  +  AGSVF+G +SPE+AGDY
Sbjct: 290 AKNSAIILVRSLDEALEISNRFAPEHLSIPDA---SLLPGVRHAGSVFVGPYSPEAAGDY 346

Query: 362 ASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKN 421
           ASG NHVLPT G       L + D+ K ++VQ L++     LA +I TLA AE L AH  
Sbjct: 347 ASGPNHVLPTSGAARQRGGLSVTDYVKVISVQNLTEPALRRLAPSITTLARAEGLEAHAR 406

Query: 422 AVTLRVNA 429
           +V +R+  
Sbjct: 407 SVEVRLTR 414


>UniRef50_UPI00016BFCCC histidinol dehydrogenase n=1 Tax=Epulopiscium sp. 'N.t. morphotype
           B' RepID=UPI00016BFCCC
          Length = 419

 Score =  493 bits (1270), Expect = e-138,   Method: Composition-based stats.
 Identities = 172/431 (39%), Positives = 245/431 (56%), Gaps = 17/431 (3%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              I+D        +   +++ +   S  I R   +I++ VK  GD+AL +Y+ KFD+  
Sbjct: 1   MIKIVD--------KNTEILKHSAEISPQIERDAQEIVETVKRLGDQALFDYALKFDRAQ 52

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
           +T+L VS +E+  A E + D+L   +  A KNIE FH  Q      VE + G+   Q   
Sbjct: 53  LTSLLVSEQELKDAYEXIDDDLLGVIRRAKKNIEDFHKRQITNSFMVE-KDGIIMGQRVT 111

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGV 178
           P+  VG+YIPGG A   S+VLM   PA +AGC  + + +PP     +A EIL    + GV
Sbjct: 112 PIERVGIYIPGGXAVYPSSVLMNVIPAKLAGCSYISVVTPPREDGTVAKEILAICAMLGV 171

Query: 179 QDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSE 238
             VF +GGA AIAALA+GTESV  V KI GPGNA+V  AK+ V  ++    IDM AGPSE
Sbjct: 172 DQVFKIGGAGAIAALAYGTESVLPVYKITGPGNAYVAAAKKAVFGKV---GIDMIAGPSE 228

Query: 239 VLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETA 298
           +L+IAD    P  +A+D+LSQAEH   ++ ILLT + ++A  VA  +E QL++LP+ + A
Sbjct: 229 ILIIADEKQXPKIIAADMLSQAEHDMLARAILLTTSKEIAEEVATEIEIQLSKLPKEKIA 288

Query: 299 RQALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPES 357
           R +++    ++V   L++C  ISN   PEHL I   NA   +  I +AGSVFLG ++PE+
Sbjct: 289 RPSIDDNGLIVVCDTLSECFAISNDLAPEHLEIMLDNAISYLPEIKNAGSVFLGRYTPEA 348

Query: 358 AGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLT 417
            GDY +G NH LPT   +   S+L +  F K+ T  + ++E        I   A  E L 
Sbjct: 349 VGDYYAGVNHTLPTNQTSKFSSALSVDTFVKKSTFVQYTEEMLQKYKDDIVLFAKHEGLD 408

Query: 418 AHKNAVTLRVN 428
           AH  +V  R  
Sbjct: 409 AHARSVQSRFQ 419


>UniRef50_C4L171 Histidinol dehydrogenase n=1 Tax=Exiguobacterium sp. AT1b
           RepID=C4L171_EXISA
          Length = 405

 Score =  492 bits (1268), Expect = e-137,   Method: Composition-based stats.
 Identities = 148/405 (36%), Positives = 237/405 (58%), Gaps = 14/405 (3%)

Query: 30  ESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLS-DELKQAM 88
           E+    V  I+++++ARGDEAL +++ +FD       ++ + ++A+ +  ++  EL +A+
Sbjct: 11  EAWAEAVKPIVESIEARGDEALLKWTKQFDGVD----RIESVDLASFNPPVAYAELTEAL 66

Query: 89  AVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATP 148
           ++A + I TFH  Q       E     R  +   P+ SVG+Y+PGG+A   S+VLM   P
Sbjct: 67  SLAAERIRTFHARQVRQDDVFEDTM-FRLGRRYMPLDSVGVYVPGGTAVYPSSVLMNIIP 125

Query: 149 ASIAGCKKVVLCSPPP---IADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDK 205
           A +AG K+VV+ +PP    I   +L AA++ G  + F +GGAQA+AALA+GTE++  VDK
Sbjct: 126 AKVAGVKRVVMVTPPKADGIDISLLIAAKIAGADECFLIGGAQAVAALAYGTETIRPVDK 185

Query: 206 IFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPD 265
           I GPGNA+V  AK  VS  +    ID  AGPSEVL+IAD  A P +VA+DLL+QAEH  +
Sbjct: 186 IVGPGNAYVATAKALVSHIV---GIDSVAGPSEVLIIADETANPKWVAADLLAQAEHDVE 242

Query: 266 SQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQCVEISNQYGP 325
           +  I +  +  +  ++ + +ERQL +LPR + AR++L     ++ + +   +E +N    
Sbjct: 243 ATAIAIVTSETLRDQIEQELERQLVQLPRQDIARESLKRGG-VLYRTIEDAIEYANTMAA 301

Query: 326 EHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLAD 385
           EH+ +  ++   L+ +I   GS FLG  + E+ GDY +G NHVLPT G     S L + D
Sbjct: 302 EHVQLAVKDPEVLMRAIRHGGSFFLGHEAAEAFGDYIAGPNHVLPTSGTARFSSGLSVDD 361

Query: 386 FQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNAL 430
           F +R T  E+++     +      +A  E+L  H  A+ +R+  +
Sbjct: 362 FYRRQTFLEMTELD-ETITKAAIRIAKQEQLEGHARAMAVRMEDV 405


>UniRef50_Q5WIU9 Histidinol dehydrogenase 1 n=52 Tax=cellular organisms
           RepID=HISX1_BACSK
          Length = 424

 Score =  491 bits (1266), Expect = e-137,   Method: Composition-based stats.
 Identities = 147/412 (35%), Positives = 220/412 (53%), Gaps = 9/412 (2%)

Query: 27  SASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQ 86
            +   + +TV  ++  ++  G+ A+RE S +FD       ++SAEEI      + D++K 
Sbjct: 16  DSHGKVEQTVASLIARIEKEGETAVRELSRQFDNWDPEQFRLSAEEIEKIVRSVPDQVKA 75

Query: 87  AMAVAVKNIETFHTAQK--LPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLM 144
            +  A + I  F   Q+  +  ++VET+PGV       PV SVG YIPGG  P+ ++  M
Sbjct: 76  DICFAQEQIRHFAEQQRASIQDIEVETRPGVFLGHKNIPVNSVGCYIPGGRYPMVASSHM 135

Query: 145 LATPASIAGCKKVVLCSPP---PIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVP 201
               A +AG K+V+ C+PP    I    + A    G  +++ +GG QA+ A+A GTE++ 
Sbjct: 136 SILTAKVAGVKRVIGCTPPINGEIPAATVTAMHFAGADEIYILGGVQAMTAMAVGTETIE 195

Query: 202 KVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAE 261
            VD + GPGNAFV EAKRQ+  R+    ID+ AGP+EVL+IAD  A  + VA+DLL QAE
Sbjct: 196 AVDMLVGPGNAFVAEAKRQLFGRV---GIDLFAGPTEVLIIADDTADGEMVATDLLGQAE 252

Query: 262 HGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALN-ASRLIVTKDLAQCVEIS 320
           HGP S   L+T +  +A      +ERQL  LP A+ A+ A      +I+  DLA+ V  +
Sbjct: 253 HGPTSPAALITTSKKLAEETVAEIERQLQTLPTADVAKVAWEEHGMIILVDDLAEAVVEA 312

Query: 321 NQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSS 380
           ++   EH+ + T N    +D +T+ G++FLG  +  + GD   GTNH LPT         
Sbjct: 313 DKLAYEHVQVLTENPNYFLDHMTNYGALFLGPETNVAYGDKVIGTNHTLPTKKAAKYTGG 372

Query: 381 LGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNALKE 432
           L +  F K  T Q  + E  + +    E L   E    HK   +LRV    +
Sbjct: 373 LWVGKFLKNCTYQRCTPEASAEIGRIAERLCELEGFIGHKAQASLRVKRYGK 424


>UniRef50_Q67KH6 Histidinol dehydrogenase n=1 Tax=Symbiobacterium thermophilum
           RepID=HISX_SYMTH
          Length = 439

 Score =  491 bits (1265), Expect = e-137,   Method: Composition-based stats.
 Identities = 163/430 (37%), Positives = 234/430 (54%), Gaps = 12/430 (2%)

Query: 13  TAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA--LKVSA 70
             +   + L R        I   V  IL+ V+  GD AL  ++ +FD   + A  L+V+ 
Sbjct: 6   EPQAFLEFLNRRRTEFYPEIEAQVRAILERVRREGDGALYAFTRQFDGADLEATGLRVTE 65

Query: 71  EEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLY 130
            E   A   +S   + A+ VAV+NI  FH  Q           G    Q   PV   G+Y
Sbjct: 66  AEYREAEAAVSAAFRAALQVAVENIAAFHRPQVPTSWFTTRPDGTIVGQRVTPVDRAGVY 125

Query: 131 IPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQDVFNVGG 186
           +PGGSAPLFS +LM A PA +AG  +V++C+PP     I   +L AA+  GV+DV+ VGG
Sbjct: 126 VPGGSAPLFSCLLMTAIPAVVAGVPEVIVCTPPDRNGRIDPHMLVAARAAGVKDVYKVGG 185

Query: 187 AQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSG 246
           AQAI A+A+GT +VP+VDKI GPGN +VT AK+ V   +    IDM AGP+EV+ + D  
Sbjct: 186 AQAIGAMAYGTATVPRVDKIAGPGNYYVTLAKKLVFGPV---GIDMLAGPTEVMAVDDGS 242

Query: 247 ATPDFVASDLLSQAEHGPDSQVILLTPA-ADMARRVAEAVERQLAELPRAETARQAL-NA 304
              +++A+DLLSQAEH P+  VIL+T A  +    V  A+ R  A LPRAET R+++   
Sbjct: 243 VDAEWLAADLLSQAEH-PNGMVILVTTAGPERIAAVGAAMARHTAALPRAETIRRSVAEL 301

Query: 305 SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASG 364
              +    L +  ++ N  GPEHL +   +    +  +  AGS+FLG W+PE+ GDY +G
Sbjct: 302 GAALAVDTLEEAADLVNAVGPEHLEVGVADPWAFLPLVRHAGSIFLGRWTPEAMGDYIAG 361

Query: 365 TNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVT 424
            ++V+PT G     S + +  F KR  V   S+  F A A     LA  E L AH  ++ 
Sbjct: 362 PSNVIPTEGTARYASPVCVETFIKRSAVTCYSEAAFRAQAPHAVRLALTEDLLAHAASMQ 421

Query: 425 LRVNALKEQA 434
           +R+     ++
Sbjct: 422 IRLAKPDGES 431


>UniRef50_B1H0F0 Histidinol dehydrogenase n=1 Tax=uncultured Termite group 1
           bacterium phylotype Rs-D17 RepID=B1H0F0_UNCTG
          Length = 419

 Score =  489 bits (1260), Expect = e-137,   Method: Composition-based stats.
 Identities = 144/411 (35%), Positives = 236/411 (57%), Gaps = 22/411 (5%)

Query: 21  LMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA--LKVSAEEIAAASE 78
           +++     ++ I+  V+DI++++K  GDEA+ +Y  KFD   ++    +VS + I  A++
Sbjct: 9   IIKTNQMDAKQISIYVSDIIEDIKNNGDEAVFKYLKKFDNVDLSKKGYRVSQKVIDDAAK 68

Query: 79  RLSDELKQAMAVAVKNIETFHTAQKL--PPVDVETQPGVRCQQVTRPVASVGLYIPGGSA 136
           R+  +LK  +  +  NI  +H  ++          + G++  Q  RPV SVGLY+PGG  
Sbjct: 69  RIPKQLKNVIKSSYSNILAYHKYERSQIKKRWNYVKNGLKIGQFYRPVESVGLYVPGGRF 128

Query: 137 PLFSTVLMLATPASIAGCKKVVLCSPPP-IADEILYAAQLCGVQDVFNVGGAQAIAALAF 195
           P  STV+M A PA  AG K++V+ +PP  + D +L++A+LCG+++++ +GG  A+ ALA+
Sbjct: 129 PYPSTVIMTAVPAMAAGVKRIVMVTPPKNMNDAVLFSAKLCGIKEIYCIGGVMAVGALAY 188

Query: 196 GTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASD 255
           GT+++ KVD I GPGNA+V EAK+QV  R+    ID  AGP+EV +IAD     D+V +D
Sbjct: 189 GTKTLKKVDMIVGPGNAYVNEAKKQVFGRV---GIDSLAGPTEVAIIADKDVPTDYVVAD 245

Query: 256 LLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQ 315
           +++Q EH P ++  LL  +A     + + + ++  +  R E                L +
Sbjct: 246 VMAQVEHDPLAKTYLLCESAKKMSEIEKLLPKEALKQLRTELC-------------SLNK 292

Query: 316 CVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYT 375
            V+I N   PEHL +  +N + L+ ++ +AG+VF+G  +P ++GDY +G +HVLPT G  
Sbjct: 293 AVDIVNNIAPEHLELLVKNYQILLKNVRNAGAVFVGYQTPTASGDYWAGPSHVLPTNGSA 352

Query: 376 ATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
              S L +  F KR    E++K    A   TI   A AE +  HK +  +R
Sbjct: 353 KFSSGLSVMTFLKRSAYIEMNKNNKKAYK-TIADFAQAENMQYHKKSAEVR 402


>UniRef50_D1N997 Histidinol dehydrogenase n=2 Tax=Lentisphaerae RepID=D1N997_9BACT
          Length = 431

 Score =  487 bits (1255), Expect = e-136,   Method: Composition-based stats.
 Identities = 170/436 (38%), Positives = 239/436 (54%), Gaps = 13/436 (2%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              +   ++      ++L  RP  S    I      I+ +VKA GD AL  Y+AKFD   
Sbjct: 1   MKKLYFGSADFEADLKKLYDRP--SYPPEIEAQAAAIIADVKAEGDAALVRYAAKFDHAE 58

Query: 63  VTA--LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQV 120
           +T    +V+ +EIAAA ++L   LK A+  A++ +  F             +PGV   + 
Sbjct: 59  LTPAQFRVTGDEIAAAEKQLPARLKSAIRTALRQVRDFAKLTIPKGWTASPRPGVTLGEK 118

Query: 121 TRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLC 176
             P+  VG+YIPGG+APL STVL  A  A  A  K++V  +PP     +   +LYA +L 
Sbjct: 119 FEPLDRVGVYIPGGTAPLVSTVLHTAGIAGAAKVKEIVAVTPPGRDGKVHPAVLYAMKLA 178

Query: 177 GVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGP 236
           GV +++ +GG   +AALA GTE++ KV+KI GPGNA+VT AK+ +  ++   AIDM AGP
Sbjct: 179 GVTEIYRLGGVYGVAALACGTETIAKVEKIVGPGNAYVTAAKKLLYGQV---AIDMVAGP 235

Query: 237 SEVLVIADSGATPDFVASDLLSQAEHGPD-SQVILLTPAADMARRVAEAVERQLAELPRA 295
           SE+LVIAD  A P F+A+DLLSQAEHG    Q +L+T    M  RV     RQ A LPR 
Sbjct: 236 SEILVIADETADPSFIAADLLSQAEHGSGLEQAVLVTTDKAMIDRVEAEFLRQKATLPRL 295

Query: 296 ETARQALNAS-RLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWS 354
            T  +       LI T DL     I++ Y PEHL IQT    ++   IT+AG++FLG W+
Sbjct: 296 ATVDRVQEHGLFLIHTPDLDTAAAIASSYAPEHLEIQTARPEQVARKITAAGAMFLGKWT 355

Query: 355 PESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAE 414
           PE  GD+ +G +HVLPT       + L    F +R ++ + ++       S +E  A  E
Sbjct: 356 PEPVGDFCAGPSHVLPTASSARYFNGLETVSFFRRSSIVKYTEAAIRREVSMVEAFAEME 415

Query: 415 RLTAHKNAVTLRVNAL 430
            L AH  + T+RV  L
Sbjct: 416 GLAAHGRSGTIRVKPL 431


>UniRef50_Q7UX39 Histidinol dehydrogenase n=6 Tax=Planctomycetaceae RepID=HISX_RHOBA
          Length = 460

 Score =  486 bits (1252), Expect = e-136,   Method: Composition-based stats.
 Identities = 152/402 (37%), Positives = 225/402 (55%), Gaps = 11/402 (2%)

Query: 34  RTVNDILDNVKARGDEALREYSAKFDKTTV--TALKVSAEEIAAASERLSDELKQAMAVA 91
             V  I  +V+++G EAL  Y+   D   +    L+V  E++ AA      +L + +   
Sbjct: 63  EVVETICKDVQSQGTEALLRYTKSLDGAELTADTLRVPEEDLKAAHAVADPKLIETIGRI 122

Query: 92  VKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASI 151
             NI TF +A     V +  +PGV   Q   P+  VG+ +PGG+A   STV+M A PA +
Sbjct: 123 RDNIATFQSAILHRDVTITPRPGVSLTQRYVPIPRVGICVPGGAAAYPSTVMMTAIPAQV 182

Query: 152 AGCKKVVLCSPPPI----ADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIF 207
           AG  ++ + +PP        ++L      G+++V+  GGAQA+AA+A+G +++P VDKI 
Sbjct: 183 AGVDEIAVVAPPTPFGAYNTDMLATCHELGIKEVYRCGGAQAVAAMAYGCDALPAVDKIV 242

Query: 208 GPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQ 267
           GPGN FV  AK+ V   +D   ID  AGPSEV+VIAD  A   FVASDLL+QAEH P S 
Sbjct: 243 GPGNLFVALAKKHVFGTVD---IDSFAGPSEVIVIADESANAAFVASDLLAQAEHSPGS- 298

Query: 268 VILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVEISNQYGPE 326
            IL+T    +   V   + RQL EL R + AR AL +   L++ +D     E+++ + PE
Sbjct: 299 AILITWDESLLTSVQAELSRQLGELERGDLARDALSDFGALVLARDADHACELTDSFAPE 358

Query: 327 HLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADF 386
           HL I+TR    L+  I  +G+ FLG  +P + GDYA+G +HVLPT G     + L    F
Sbjct: 359 HLQIETREPESLIAKIRHSGAAFLGHHTPVALGDYAAGPSHVLPTGGTCRWAAGLSANSF 418

Query: 387 QKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVN 428
            +  +V +  +   SA+A  + T+A  E LTAH  ++++R  
Sbjct: 419 LRSGSVTQFDQSALSAIAQDVITVAEKEGLTAHARSISIRTE 460


>UniRef50_A6UA68 Histidinol dehydrogenase n=4 Tax=Proteobacteria RepID=A6UA68_SINMW
          Length = 432

 Score =  486 bits (1251), Expect = e-136,   Method: Composition-based stats.
 Identities = 155/409 (37%), Positives = 223/409 (54%), Gaps = 6/409 (1%)

Query: 23  RPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSD 82
           R A+S +  + +TV +I+ NV+ RGD A+REYSA FDK  +   +VS EE   A   L  
Sbjct: 20  RDAVSDTAPVEKTVKEIIANVRERGDAAVREYSAAFDKVELEKFEVSQEERLKAVAELDP 79

Query: 83  ELKQAMAVAVKNIETFHTAQKLP--PVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFS 140
           + ++    A+ N+  F  AQ     P+++ET PG+       P+  VG Y+PGG  PL S
Sbjct: 80  QTREDTEFAIANVRAFAEAQLKTILPLEIETLPGLHLGHRVIPIEIVGCYVPGGRYPLLS 139

Query: 141 TVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESV 200
             +M   PA +AGC +V+ C PP     ++    L G   +F VGGAQAIAA+A GTE++
Sbjct: 140 APVMTIVPAKVAGCDQVIACLPPNAHPAMIAGCHLSGADRIFRVGGAQAIAAMASGTETI 199

Query: 201 PKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQA 260
           P VDKI GPGNAFV EAKRQV  ++    ID  AGPSE+ ++AD       +A+DLL+QA
Sbjct: 200 PAVDKIVGPGNAFVNEAKRQVFGQV---GIDQLAGPSEIFIVADETGKAAMIATDLLAQA 256

Query: 261 EHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVEI 319
           EH   ++V L+T    +A      VE+QL +L  A  A  A  +   + V +D    +  
Sbjct: 257 EHDVRTRVGLITTDRKLAEETLVEVEKQLQDLSTANVASVAWKDYGEITVCEDETTMIAY 316

Query: 320 SNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCS 379
           S+    EHL + TR+ +     + + GS+F+G+ +     D   GTNH LPT        
Sbjct: 317 SDYIAAEHLQVHTRDPQATARKLRNYGSLFIGELASVVYSDKCCGTNHTLPTMAAGRYTG 376

Query: 380 SLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVN 428
            L +  + K  T Q L + G +A+A      +A ERL  H+ A  LR++
Sbjct: 377 GLWVGSYLKTCTHQWLDERGVAAVAPAAVRQSATERLEGHRRAAALRLS 425


>UniRef50_Q8TXG3 Histidinol dehydrogenase n=1 Tax=Methanopyrus kandleri
           RepID=HISX_METKA
          Length = 431

 Score =  485 bits (1249), Expect = e-135,   Method: Composition-based stats.
 Identities = 168/408 (41%), Positives = 230/408 (56%), Gaps = 11/408 (2%)

Query: 31  SITRTVNDILDNVKARGDEALREYSAKFDKTTVT--ALKVSAEEIAAASERLSDELKQAM 88
            +   V  I ++V  RGDEAL EY+ +FD   +    L+VS ++   A E + +   +A+
Sbjct: 25  EVLPDVERIFEDVVERGDEALLEYTERFDGVKLEAEDLRVSEDDFEVARELVDERTVEAL 84

Query: 89  AVAVKNIETFHTAQKLP-PVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLAT 147
             A   IE FH               G  C    RP+  VG Y+PGG A   ST LM   
Sbjct: 85  EEAAHRIEEFHRKTLPRVDRITFDVEGTECGLTLRPIPRVGCYVPGGRAAYPSTALMTVI 144

Query: 148 PASIAGCKKVVLCSPP-----PIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPK 202
           PA +AGC++VV+C+PP       + E+L A ++ G   V+ VGGAQAIAALA GTE+V +
Sbjct: 145 PARVAGCREVVVCTPPADNDVRASPEVLVAVEIAGADAVYRVGGAQAIAALAAGTETVLR 204

Query: 203 VDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEH 262
           VDKI GPGN +VT AK     R     +DMPAGPSEV VIAD  A PD++A DL++QAEH
Sbjct: 205 VDKIVGPGNVYVTAAKLLAYSR-GLTDVDMPAGPSEVFVIADDSANPDWLARDLIAQAEH 263

Query: 263 GPDSQVILLTPAADMARRVAEAVERQL-AELPRAETARQALN-ASRLIVTKDLAQCVEIS 320
            P +  +L T + ++AR V E VE  L A + R E   +AL+    ++V   L +CV ++
Sbjct: 264 DPHAAAVLATDSEEIARAVKERVEELLDAGIEREEIVLKALDRNGWIVVLDSLEECVRLA 323

Query: 321 NQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSS 380
           N+Y PEHL +   N  EL+  + +AG+VF+G  +    GDYA+G NHVLPT G+     +
Sbjct: 324 NRYAPEHLQLCVENPEELLQDVENAGAVFVGHLTAVPFGDYATGPNHVLPTGGFARARGA 383

Query: 381 LGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVN 428
           LG  DF K + +Q L +     LA  +E LA  E L  H  AV  R +
Sbjct: 384 LGTWDFVKIIPIQRLREGDVERLAPIVEELAEREGLPNHAEAVRARRS 431


>UniRef50_Q483H8 Histidinol dehydrogenase 2 n=15 Tax=Proteobacteria
           RepID=HISX2_COLP3
          Length = 446

 Score =  485 bits (1248), Expect = e-135,   Method: Composition-based stats.
 Identities = 150/442 (33%), Positives = 231/442 (52%), Gaps = 16/442 (3%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDK--T 61
             I   +  +AEQ+ +LL R   +    I   V  I++NVK  GD+AL EY+ KFDK   
Sbjct: 5   VKIHRLSDLSAEQRNKLLQRTESNLDNFI-DIVKPIIENVKLNGDKALSEYAKKFDKAEV 63

Query: 62  TVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPP-VDVETQPGVRCQQV 120
           +   ++V+  E   A   + +E+ Q ++ ++ NI+ FH AQ        + +PG      
Sbjct: 64  STDQIQVTQAEFDEAFTLVDEEVIQTLSYSIDNIKKFHEAQMPEEMWMKQIRPGCYAGDR 123

Query: 121 TRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLC 176
             P+ +V  YIP G     S  +M A PA +AG    ++ +PP     +    L  A+L 
Sbjct: 124 FTPINAVACYIPRGKGSFPSVAIMTAVPAIVAGVPTAIIITPPGTDGKVDAATLVVAKLV 183

Query: 177 GVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGP 236
           G+  VF  GGAQ IAA+A+GT +VPK DK+ GPG+ FV  AK+ ++  +       PAGP
Sbjct: 184 GIDKVFKCGGAQGIAAVAYGTNTVPKCDKVVGPGSPFVVAAKKLLADIIHPGT---PAGP 240

Query: 237 SEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPR-- 294
           SE +V+AD  A P   A DLL +AEHGPDS   L+T + ++A +   A+      + R  
Sbjct: 241 SEAIVLADDTANPKLAALDLLVEAEHGPDSSAFLVTNSKELAEQAQVAINEYWQHMDRLR 300

Query: 295 AETARQAL--NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGD 352
            + +   L  +   +++T    + V+  N Y  EHL+I +++  + +  I +AG + LG+
Sbjct: 301 VDFSSTVLSGDNGGIVLTSTFEEAVDFCNDYAAEHLLILSKSPFDHLGKIINAGEILLGE 360

Query: 353 WSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAA 412
            +P S  +Y  G N VLPT     T S L + D+ K  ++  L++EG+  LA      A 
Sbjct: 361 NTPISIANYTLGPNAVLPTSMAAKTASPLSVFDYLKSCSIGYLTREGYEELAPHTYRFAK 420

Query: 413 AERLTAHKNAVT-LRVNALKEQ 433
            E   AH NAV+ LR  A+K +
Sbjct: 421 YEGFDAHANAVSHLRDEAIKSE 442


>UniRef50_A1ZJE8 Histidinol dehydrogenase n=1 Tax=Microscilla marina ATCC 23134
           RepID=A1ZJE8_9SPHI
          Length = 429

 Score =  483 bits (1245), Expect = e-135,   Method: Composition-based stats.
 Identities = 171/435 (39%), Positives = 262/435 (60%), Gaps = 12/435 (2%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              II       E   +L  R      E++ + V  IL  V+  GD+ALR +  K+D+  
Sbjct: 1   MEKIIY---PHKEDWSKLQERT-FETYEALEKAVRPILRRVQREGDKALRSFVFKYDRVR 56

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
           +   +++ EE+A AS  +SDELK+A+ VA  NI TFH  Q      +ET  GV   Q   
Sbjct: 57  IKRFQLTPEELAEASNHVSDELKEAINVAKYNIATFHLTQTKAVKKIETTEGVFSWQKNV 116

Query: 123 PVASVGLYIPG-GSAPLFSTVLMLATPASIAGCKKVVLCS----PPPIADEILYAAQLCG 177
           P+A VGLY+P  G APL+S +LM+   A+IAGCK+++LCS       I   ILY A L  
Sbjct: 117 PIAKVGLYVPSTGDAPLYSHILMMGILANIAGCKEIILCSAANHEGRIHPIILYTAHLLN 176

Query: 178 VQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPS 237
           ++ V+ VGG QAIAA+A+GTE++PKVDKIFGP N +V+ AK+ VS+  +  AIDMP GPS
Sbjct: 177 IKKVYRVGGVQAIAAMAYGTETIPKVDKIFGPSNEYVSTAKQLVSK--NDVAIDMPVGPS 234

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELP-RAE 296
           E+  +AD    P + A+D+L+ AE    +Q+++LT A ++A ++   V++QL ELP + E
Sbjct: 235 ELCYVADQSTNPVYAAADILAHAEQSSHNQLVVLTNAEEVADKIQAEVDKQLNELPLKKE 294

Query: 297 TARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPE 356
            A++    +++IV K   + +  +N+Y PE+L++   NA  + D IT+A S+ LG  +P 
Sbjct: 295 VAKEVFKNAKIIVFKSNVESIAFANEYAPENLVLAIDNAEAVGDRITNASSIHLGHLTPP 354

Query: 357 SAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERL 416
           + G YA+G NH+LP+ G+  + S L +  F K++  Q+++  G   + ST+ T++ AE L
Sbjct: 355 AVGYYAAGPNHILPSNGFARSYSGLSVDSFVKKINFQQVTPLGLQNVGSTVATMSEAEEL 414

Query: 417 TAHKNAVTLRVNALK 431
              KN++  R+  L 
Sbjct: 415 LGRKNSIIKRLELLD 429


>UniRef50_UPI00017455E1 Histidinol dehydrogenase n=1 Tax=Verrucomicrobium spinosum DSM 4136
           RepID=UPI00017455E1
          Length = 428

 Score =  482 bits (1241), Expect = e-134,   Method: Composition-based stats.
 Identities = 158/430 (36%), Positives = 240/430 (55%), Gaps = 11/430 (2%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
             I+ +           L R A + S+ +   V  ++ +++  GD+AL E + KFD  T+
Sbjct: 1   MRILRYTDAAYADALCRLNRRAEA-SDRVRDVVAAVIADIRQNGDKALLELTQKFDGATL 59

Query: 64  --TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVT 121
               L VS EE+AAA   L+ E++ A+  +++N+ TF          +  + G    +V 
Sbjct: 60  TAEQLVVSTEEVAAAVASLTPEVRAALDASLRNVTTFAHQSLRKDWSMINEQGAEVGEVY 119

Query: 122 RPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLC----G 177
            P   VG+Y+PGG+APL ST +M    A+ AG  ++V+CSP     ++           G
Sbjct: 120 HPFERVGVYVPGGTAPLVSTAIMTVAIAAAAGVPEIVVCSPCGKDGKVNANLLAALSLAG 179

Query: 178 VQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPS 237
             +++ VGG+QAIAA+AFGTE++  V KIFGPGN++V EAKRQV   +   ++D+  GPS
Sbjct: 180 ATEIYRVGGSQAIAAMAFGTETIKPVTKIFGPGNSYVVEAKRQVFGVV---SVDLLPGPS 236

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAET 297
           EV+V+ADS A P F+A+DLL+QAEHG DS V  LT    +   V   VE Q  +L R E 
Sbjct: 237 EVMVLADSSANPAFIAADLLAQAEHGKDSGVAFLTDDETLLNAVVSQVETQGQKLTRQEM 296

Query: 298 ARQALNAS-RLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPE 356
            R  L+    L++   L +  EI N Y PEHL + T    +++  I +AG++FLG++SP 
Sbjct: 297 VRSVLDKECFLMLVPTLEEGAEIVNNYAPEHLSLITAREHDILPLIRTAGAIFLGNYSPV 356

Query: 357 SAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERL 416
           + GD+ +G +H LPT G   +   L +  FQKR ++  LSKE  +     +   +  E L
Sbjct: 357 AVGDFLAGPSHTLPTGGAGKSFPGLTVDMFQKRTSIVRLSKEACAKSEPIVRVFSEIEGL 416

Query: 417 TAHKNAVTLR 426
            AH  +V++R
Sbjct: 417 DAHGLSVSVR 426


>UniRef50_B3T638 Histidinol dehydrogenase n=1 Tax=uncultured marine crenarchaeote
           HF4000_ANIW141N1 RepID=B3T638_9ARCH
          Length = 434

 Score =  482 bits (1241), Expect = e-134,   Method: Composition-based stats.
 Identities = 157/443 (35%), Positives = 243/443 (54%), Gaps = 26/443 (5%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              I+   +  +      +       SE   +TV  IL++V+  GD A+++Y  KF+   
Sbjct: 1   MIKILQVRNVDS-----FVEYRRQKTSEKDRKTVQAILNDVRKNGDSAVKKYERKFNGRK 55

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFH----TAQK--------LPPVDVE 110
            + L+VS +EI  A E           + ++  + +       QK          P    
Sbjct: 56  TSQLRVSNKEIGEAEELPDPTDNIWTKLYLQEWDLYWNLSGRKQKLRKGGFCYEKPYFWG 115

Query: 111 TQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIA 166
             P ++ ++   P+ SVG YIPGG A   S+V+M   PA IAG K++V+ SPP     I 
Sbjct: 116 GLP-LKTEKRFVPIPSVGCYIPGGQARYPSSVVMSVLPAKIAGVKRIVIVSPPGRDGKID 174

Query: 167 DEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLD 226
              + AA +CGV +++ VGGAQAI ALA+GT+S+PKVDKI GPG  FV+ AK  VS   +
Sbjct: 175 PLTISAAAMCGVTEIYKVGGAQAIGALAYGTKSIPKVDKIVGPGGKFVSIAKAIVS---E 231

Query: 227 GAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVE 286
             +IDM AGP+E+ ++AD+ + P+ VA DL+SQAEH  D+   ++T +  +A+++ +++E
Sbjct: 232 QTSIDMIAGPTELGIMADTSSDPELVALDLISQAEHSKDTMCFVITQSKIIAKQIQKSIE 291

Query: 287 RQLAELPRAETARQAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSA 345
           + +    R+   R++L     + V K+  + +E++N+  PEHL +  +NAR L   IT A
Sbjct: 292 KLIPGTERSSIIRESLTKNGFIAVCKNENEMIELANKIAPEHLELMVKNARSLSKKITGA 351

Query: 346 GSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALAS 405
           G + +G  +P SA DY  GTNH+LPT G+  T   L + DF K  T+ E  K    AL+S
Sbjct: 352 GLLLIGKNTPSSASDYILGTNHILPTNGFGRTRGGLSVLDFLKLQTIVESKKSTLKALSS 411

Query: 406 TIETLAAAERLTAHKNAVTLRVN 428
            ++ L  AE L  H  AV  R++
Sbjct: 412 DLKALTDAEGLPNHYKAVKRRLD 434


>UniRef50_C0G418 Histidinol dehydrogenase n=2 Tax=Rhizobiales RepID=C0G418_9RHIZ
          Length = 444

 Score =  481 bits (1240), Expect = e-134,   Method: Composition-based stats.
 Identities = 155/411 (37%), Positives = 218/411 (53%), Gaps = 14/411 (3%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
             T +       EQ+    +      SE + R V +I+D V+  GD AL +YS +FD+  
Sbjct: 1   MVTTLRQTDPDFEQKFAAFLSGKREVSEDVDRAVREIVDRVRREGDSALLDYSRRFDRID 60

Query: 63  VTA--LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQV 120
           +    + V+  EI AA +       +A+ +A   IE  H  Q           GV     
Sbjct: 61  LEKTGIAVTEAEIDAAFDAAPASTVEALKLARDRIEKHHARQLPKDDRYTDALGVELGSR 120

Query: 121 TRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCG 177
              + +VGLY+PGG+A   S+VLM A PA +AG  ++V+  P P   +   +L AA+L G
Sbjct: 121 WTAIEAVGLYVPGGTASYPSSVLMNAMPAKVAGVDRIVMVVPAPDGNLNPLVLVAARLAG 180

Query: 178 VQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPS 237
           V +++ VGGAQAIAALA+GTE++  V KI GPGNA+V  AKR V   +    IDM AGPS
Sbjct: 181 VSEIYRVGGAQAIAALAYGTETIRPVAKIVGPGNAYVAAAKRIVFGTV---GIDMIAGPS 237

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAET 297
           EVL++AD    PD++A+DLL+QAEH   +Q IL+T     A  V EAVERQL  L R ET
Sbjct: 238 EVLIVADKDNNPDWIAADLLAQAEHDTAAQSILMTNDEAFAHAVEEAVERQLHTLARTET 297

Query: 298 ARQAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPE 356
           A  +  +   +I+ KD    + ++N+   EHL I   +A   V  I +AGS+F+G ++P 
Sbjct: 298 ASASWRDFGAVILVKDFEDAIPLANRIAAEHLEIAVADAEAFVPRIRNAGSIFIGGYTPG 357

Query: 357 SAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQEL-SKEGFSALAST 406
           S      G   + P     A C  L L  F  R+    L S+ G  A + T
Sbjct: 358 SDRRLCGG---LQPCAANGALCPFL-LRPFGARLYEAHLASQAGLRAASRT 404


>UniRef50_Q13I58 Histidinol dehydrogenase n=22 Tax=cellular organisms
           RepID=Q13I58_BURXL
          Length = 443

 Score =  481 bits (1239), Expect = e-134,   Method: Composition-based stats.
 Identities = 141/424 (33%), Positives = 211/424 (49%), Gaps = 10/424 (2%)

Query: 17  QRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAA 76
           +R         +   +   V  I+ +++ +GDEA+REYS KFD       ++S  EI  A
Sbjct: 10  KRGRTAAGKSDSDAKVRAIVESIIQHIEEKGDEAVREYSRKFDNWDPGDFRLSRPEIETA 69

Query: 77  SERLSDELKQAMAVAVKNIETFHTAQK--LPPVDVETQPGVRCQQVTRPVASVGLYIPGG 134
            ++LS    + +A A   +  F   Q+  +  V+ ET PGV       P+ +VG YIPGG
Sbjct: 70  RKQLSAREIEDIAFAQTQVRNFARIQRDSMRDVETETLPGVVLGHKHIPMNAVGCYIPGG 129

Query: 135 SAPLFSTVLMLATPASIAGCKKVVLCSPP---PIADEILYAAQLCGVQDVFNVGGAQAIA 191
             PL ++  M    A +AG  +VV  +PP        I+ A  + G  ++  +GG QA+ 
Sbjct: 130 KYPLLASAHMSVLTAKVAGVARVVSTAPPYQGKPHPAIVTAMDMAGADEILVLGGIQAVV 189

Query: 192 ALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDF 251
           A+A GT +V  VD + GPGN FV EAKRQ+  R+    ID+ AGP+E LVIAD     + 
Sbjct: 190 AMAVGTPTVAPVDMLVGPGNMFVAEAKRQLYGRV---GIDLFAGPTETLVIADESVDGEL 246

Query: 252 VASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVT 310
            A DLL QAEHG  S  ILLT +  +AR     +ERQL  LP A  A Q+  +   +IV 
Sbjct: 247 CAVDLLGQAEHGATSPSILLTNSEKLARDTLAEIERQLKILPTASIAAQSWADCGEVIVC 306

Query: 311 KDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLP 370
               + +++++    EH+ + T +    ++++T+ G++FLG  +  S GD   GTNH LP
Sbjct: 307 DTYEEMLQVADDIASEHVQVMTEDPDFFLNNMTNYGALFLGPRTNVSFGDKVIGTNHTLP 366

Query: 371 TYGYTATCSSLGLADFQKRMTVQEL-SKEGFSALASTIETLAAAERLTAHKNAVTLRVNA 429
           T         L +  F K  T Q + + E  + +      L   E    H     +RV  
Sbjct: 367 TNRSARYTGGLWVGKFLKTCTYQRVTTNEASAIIGEYCSRLCHMENFAGHGEQANIRVRR 426

Query: 430 LKEQ 433
              +
Sbjct: 427 YGNR 430


>UniRef50_P73058 Histidinol dehydrogenase 1 n=11 Tax=Cyanobacteria RepID=HISX1_SYNY3
          Length = 434

 Score =  479 bits (1233), Expect = e-133,   Method: Composition-based stats.
 Identities = 162/438 (36%), Positives = 249/438 (56%), Gaps = 14/438 (3%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFD--K 60
              I+  +  T +Q  QL  R   +  +++     ++++ VK  GD  +  YS +FD   
Sbjct: 1   MTRILKLSHLTPQQLNQLKRRSEQNIDQAL-AIAKEVIEQVKMEGDAGVLHYSRQFDFAG 59

Query: 61  TTVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDV-ETQPGVRCQQ 119
            T   L+VS  E A A + +  EL++A+  A +NIE  H  Q  PP+ + E +PGV   +
Sbjct: 60  ATAENLRVSEAEFAEAEKLVDPELRRAVEHAFRNIEKVHAGQMPPPMHLAEIEPGVFAGE 119

Query: 120 VTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQL 175
              P+ +VGLY+P G     S +LMLA PA +AG KK+V+C+PP     +    L  A++
Sbjct: 120 KITPLPTVGLYVPRGKGAFPSMMLMLAVPARVAGVKKIVVCTPPDKEGKVEPVSLVTARM 179

Query: 176 CGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAG 235
            GV +V+ +GG QA+AA+A+GT++V KVDK+ GP + +   AKR +S  +D   + +PAG
Sbjct: 180 AGVDEVYKLGGVQALAAIAYGTKTVSKVDKLIGPCSIYGAAAKRLLSGIVD---VGLPAG 236

Query: 236 PSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELP-- 293
           PSE +V+AD    P   A DLL +AEHG DS  +L+T +A +A +    +   L +LP  
Sbjct: 237 PSESIVLADETTDPKLAALDLLIEAEHGSDSAALLVTHSASLAEKALGYLGEYLEKLPPW 296

Query: 294 RAETARQAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGD 352
           R +     L +   +++T  L   ++  N Y PEHL + T +  +LV  I +AG + LG+
Sbjct: 297 RKKFCEDGLGSYGGILLTDSLQASLDFINDYAPEHLQVLTADPLKLVGKIDNAGEILLGN 356

Query: 353 WSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAA 412
           ++P SA  YA G N VLPT G+  + S++ + DF KR T+  L++EGF+ +  T+ TLA 
Sbjct: 357 YTPSSAATYAIGVNAVLPTGGFARSYSAVSVFDFLKRSTLAYLTEEGFAGVKETVTTLAD 416

Query: 413 AERLTAHKNAVTLRVNAL 430
            E   AH  A+  R N L
Sbjct: 417 YEDFPAHALAIRERENLL 434


>UniRef50_D0XPF3 Histidinol dehydrogenase n=1 Tax=Brevundimonas subvibrioides ATCC
           15264 RepID=D0XPF3_9CAUL
          Length = 440

 Score =  476 bits (1225), Expect = e-132,   Method: Composition-based stats.
 Identities = 176/432 (40%), Positives = 251/432 (58%), Gaps = 9/432 (2%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
              IDW S   + +   L RP+  +   +   V+ I + V   G  A+ +++ + D    
Sbjct: 6   IKRIDWASLDGQGRFDALARPSRRSERDVQDVVSGIFEQVALSGGLAVTQFAERIDGFKP 65

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPV-DVETQPGVRCQQVTR 122
             + ++ E +AAA + L     +A+ VA +N+  FH A K      VET PGV+ + V R
Sbjct: 66  RRIAITPEAVAAARDALPPADTRALRVAAENVRVFHQATKPEDTAFVETTPGVKSKLVWR 125

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGV 178
           P+ + G+Y+PGG+APLFS++LM A PA +AG    V+ +PP     +   ++ AA    +
Sbjct: 126 PIGAAGIYVPGGTAPLFSSLLMQAIPAEVAGVTTRVVVTPPAKDGSVHPAMILAAAEANL 185

Query: 179 QDVFNVGGAQAIAALAFGT----ESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPA 234
             ++ +GGAQAIAAL +G       +P  DK+FGPGNA+V EAKR  +   +G ++DMPA
Sbjct: 186 DAIWLIGGAQAIAALTYGAVLDDGEIPACDKLFGPGNAYVAEAKRYAAALPNGPSVDMPA 245

Query: 235 GPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPR 294
           GPSE+LVIAD    P+  A+DLLSQAEH  D+QVIL+   A     +   VE QL  LPR
Sbjct: 246 GPSELLVIADRFCDPEIAAADLLSQAEHDADAQVILVCERAATIDAILAEVEEQLTTLPR 305

Query: 295 AETARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWS 354
           A+ AR +L+ +R I+  D+A+   +SN YGPEHL IQ  +A  LV SI +AG+VF+G W+
Sbjct: 306 ADIARASLSEARAILVSDMAEACAVSNLYGPEHLAIQAEDAEALVASIRAAGAVFVGRWA 365

Query: 355 PESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAE 414
            E+ GDYA+G +HVLPT G   T   +  A F   M+VQ +++ G   L      LA  E
Sbjct: 366 AETLGDYAAGPSHVLPTDGGARTLGGITTASFMTSMSVQTVTEAGAERLGPIAARLARLE 425

Query: 415 RLTAHKNAVTLR 426
            L AH  A  LR
Sbjct: 426 GLEAHARAADLR 437


>UniRef50_Q4JW59 Histidinol dehydrogenase n=104 Tax=Actinobacteria (class)
           RepID=HISX_CORJK
          Length = 450

 Score =  474 bits (1222), Expect = e-132,   Method: Composition-based stats.
 Identities = 158/439 (35%), Positives = 233/439 (53%), Gaps = 15/439 (3%)

Query: 7   IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTAL 66
           +   + T  + R  L R       S+  TV  I+D V+  G  A  E   +FD  T  ++
Sbjct: 13  LRGQAPTTAELRHRLPRGGTDVD-SVIPTVAPIVDQVREGGARAALEIGQRFDGVTPDSV 71

Query: 67  KVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVAS 126
           +V AE I AA   L+D++  A+  A+K +  FH+A +     VE  PG    +   PV  
Sbjct: 72  RVPAEVIDAAVGTLADDVIAALEEAIKRVRAFHSAIRPEDKQVEVAPGGIVTERFIPVQR 131

Query: 127 VGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQDVF 182
           VGLY PGG+A   S+V+M   PA  AG + +V+ SPP         +L A +L GV +V+
Sbjct: 132 VGLYAPGGNAVYPSSVIMNVVPAQEAGVESLVVASPPQEGGWPHPTVLAACKLLGVDEVW 191

Query: 183 NVGGAQAIAALAFGT-----ESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPS 237
            VGGAQA+A LA G+     E +  VD + GPGN FVT AKR     +    ID  AGP+
Sbjct: 192 AVGGAQAVALLAHGSTAEGGEELEPVDMVTGPGNIFVTAAKRLCRSVV---GIDSEAGPT 248

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAET 297
           E+ V+AD  A    +A DL+SQAEH   +  +L+T +  +A  V   +  +      +E 
Sbjct: 249 EIAVLADESANAVEIAYDLISQAEHDTMAASVLITDSEKLADEVVAEMNERYHITENSER 308

Query: 298 ARQALN--ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSP 355
             +AL+   S +++  D+A  +  +N YG EHL I T +A  +   IT+AG++F+G +SP
Sbjct: 309 VAEALSGQQSGVVLVDDIAAGIRAANAYGAEHLEIHTEDAHGVAAQITNAGAIFIGRFSP 368

Query: 356 ESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAER 415
              GDYA+G+NHVLPT G     S L    F K + V + ++EG   +A T+ TL+ +E 
Sbjct: 369 VPLGDYAAGSNHVLPTSGTARHSSGLSTLTFLKSVHVIDYNEEGLRGVADTVITLSKSEG 428

Query: 416 LTAHKNAVTLRVNALKEQA 434
           L AH  A++ R +      
Sbjct: 429 LPAHGEAISARTSTANTNG 447


>UniRef50_B4W8G9 Histidinol dehydrogenase n=2 Tax=Caulobacteraceae
           RepID=B4W8G9_9CAUL
          Length = 435

 Score =  472 bits (1216), Expect = e-131,   Method: Composition-based stats.
 Identities = 193/434 (44%), Positives = 261/434 (60%), Gaps = 9/434 (2%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
             +IDW+S  A  +R  L RPA   +  +T  V  ILD+V+ARG  A+ ++  K DK   
Sbjct: 1   MKLIDWSSLDAAGKRAALARPAQRTAGDVTDVVRTILDDVRARGGAAVTDWCLKLDKAPP 60

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPV-DVETQPGVRCQQVTR 122
             + ++ E +A A   L     +A+ +A +N+  FH A K      +ET PGVR +   R
Sbjct: 61  RRIAITPEAVAEARNALPPGDVRALRMAAENVRVFHQATKPEDTPFIETTPGVRSKLAWR 120

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGV 178
           P+AS GLYIPGG+APLFS++LMLA PA +AG  + V  +PP     I   ++ AA    +
Sbjct: 121 PIASAGLYIPGGTAPLFSSLLMLAIPAGVAGVGERVAVTPPDKNGGIHPAMILAAAEAEL 180

Query: 179 QDVFNVGGAQAIAALAFGTE----SVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPA 234
             ++ +GGAQAIAAL FG E     +P  DK+FGPGNA+V EAK+Q S    G A+DMPA
Sbjct: 181 DAIWLMGGAQAIAALTFGVELEDGIIPACDKLFGPGNAYVAEAKKQASALPGGPAVDMPA 240

Query: 235 GPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPR 294
           GPSE++VI D  A P+  A+DLLSQAEH  D+QVIL++ +      +   VE Q+A LPR
Sbjct: 241 GPSELMVIVDRDAAPEIAAADLLSQAEHDADAQVILVSTSRATIDYILSEVEVQVAALPR 300

Query: 295 AETARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWS 354
              AR +LN +R I+ +DL    E++N YGPEHL IQ  +   LVDSI +AG+VF+G ++
Sbjct: 301 EAIARASLNEARAILVRDLDAAAEVANLYGPEHLAIQIDDPEPLVDSIKAAGAVFVGRFA 360

Query: 355 PESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAE 414
            E+ GDYA+G +HVLPT G   T   +  A F   M+VQ +S+ G  ALA     LA  E
Sbjct: 361 AETLGDYAAGPSHVLPTDGGARTLGGVTTASFMTTMSVQLVSEAGARALAPIAARLARME 420

Query: 415 RLTAHKNAVTLRVN 428
            L AH  A  LR  
Sbjct: 421 GLEAHARAADLRAE 434


>UniRef50_A4QA32 Histidinol dehydrogenase n=16 Tax=cellular organisms
           RepID=A4QA32_CORGB
          Length = 408

 Score =  471 bits (1214), Expect = e-131,   Method: Composition-based stats.
 Identities = 138/403 (34%), Positives = 213/403 (52%), Gaps = 10/403 (2%)

Query: 39  ILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETF 98
           ++ +++ARGDEA+REYS KFD     +  V  E++    +R+ +++ + +      +   
Sbjct: 1   MIADIRARGDEAVREYSLKFDNYGPDSFLVQGEQLQEILDRVPEQVIEDIKFVQDQVRKV 60

Query: 99  HTAQKLP--PVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKK 156
             AQ       ++ET PGV   Q   P+ S G Y+PGG  PL ++  M    A +AG K+
Sbjct: 61  AQAQLQSMGEFEIETLPGVHIGQKNVPIDSAGAYVPGGKYPLLASAHMTILTAKVAGVKR 120

Query: 157 VVLCSP---PPIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAF 213
           VV C+P     + D  + A  L G  +++ +GG QAIAA+A GTE++  V  I GPGNAF
Sbjct: 121 VVACTPLIQGEVPDATVAAMHLAGADEIYLLGGIQAIAAMAIGTETIKPVSIIAGPGNAF 180

Query: 214 VTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTP 273
           V EAKRQ+   +    ID+ AGP+E L++AD    P   A DLLSQAEHGPDS  +L++ 
Sbjct: 181 VAEAKRQLFGEV---GIDLLAGPTETLIVADETTDPFIAAVDLLSQAEHGPDSPAVLIST 237

Query: 274 AADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQT 332
              +A +V + +   L E+P  + A  A  +   + V + +     +++++  EH+ I T
Sbjct: 238 DRAVAEQVIDHINELLPEMPTKDYAEVAWRDWGEVHVVESIEDAFSLADKFASEHVQILT 297

Query: 333 RNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTV 392
            + R  +D +   G++FLG+ +  S GD   GTNHVLPT G       L +  + + +T 
Sbjct: 298 ASPRRALDEMKHYGALFLGEGTCVSYGDKVIGTNHVLPTRGAARYTGGLWVGKYVRTITY 357

Query: 393 QELSKEGFSA-LASTIETLAAAERLTAHKNAVTLRVNALKEQA 434
           QE++ E  SA         A  ER   H  +  +R       A
Sbjct: 358 QEVTNEDSSAFFGELCGRAARVERFEGHARSGDVRAAKYAGAA 400


>UniRef50_Q64EP7 Histidinol dehydrogenase n=2 Tax=environmental samples
           RepID=Q64EP7_9ARCH
          Length = 419

 Score =  471 bits (1214), Expect = e-131,   Method: Composition-based stats.
 Identities = 172/425 (40%), Positives = 245/425 (57%), Gaps = 28/425 (6%)

Query: 16  QQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV---TALKVSAEE 72
           + +    R       ++   VN+I+  VK+RGD AL +Y+ KFD         L+V   E
Sbjct: 10  ETKDFFDRGL--DLTAVMPLVNEIIAEVKSRGDRALLDYTEKFDGVKFLRQKDLEVRRSE 67

Query: 73  IAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQP-----GVRCQQVTRPVASV 127
           I  A   + D L +++  A + I+ FH  QK      + +      G+       P+  V
Sbjct: 68  IEDAKRNVDDHLLRSIEKASEAIKKFHYRQKRRVEVEKGEDKGGTEGMFIDNTYVPLDVV 127

Query: 128 GLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEI-----LYAAQLCGVQDVF 182
           G Y+P   A  FST LM   PA IAG + +++C+PP     +     L AA+L G   +F
Sbjct: 128 GAYVP---ASYFSTALMCVIPAKIAGVRNILVCTPPGKDGAVDSLTLLAAAELAGATRIF 184

Query: 183 NVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVI 242
            VGGAQAIAALAFGTE++PKV KI GPGN +VT AK   + R  G  ID PAGPSE+++I
Sbjct: 185 KVGGAQAIAALAFGTETIPKVQKIVGPGNVYVTAAKM--AARAQGVEIDFPAGPSEIIII 242

Query: 243 ADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL 302
           AD  A P F+ +D+L+QAEHG  S+ +LLT +A    R+A  VERQ+    R E   +  
Sbjct: 243 ADETANPLFIVADMLAQAEHGAKSKAVLLTDSA----RIAAEVERQI----RTEAGDEEG 294

Query: 303 NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYA 362
             + +I+  D+ +C+E++N+Y PEHL I  R  +E++  I +AGSVF+GD+SP +AGDYA
Sbjct: 295 EQNGIILGDDIGECIELANEYAPEHLEIMVREPKEVLKRIKNAGSVFVGDYSPVAAGDYA 354

Query: 363 SGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNA 422
           +G NHVLPT GY  + S L +  F +RMTVQ L KEG + +   +  ++ AE +  H  +
Sbjct: 355 TGANHVLPTAGYAKSFSGLDVHHFMRRMTVQWLDKEGLAKIKDVVVKMSRAEGMEKHAQS 414

Query: 423 VTLRV 427
           V  R 
Sbjct: 415 VEARF 419


>UniRef50_D2RSH8 Histidinol dehydrogenase n=1 Tax=Haloterrigena turkmenica DSM 5511
           RepID=D2RSH8_9EURY
          Length = 432

 Score =  470 bits (1210), Expect = e-131,   Method: Composition-based stats.
 Identities = 161/430 (37%), Positives = 240/430 (55%), Gaps = 10/430 (2%)

Query: 9   WNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKV 68
                   +     R   +  ++I+  V +I+D V   GD A+RE++++FD   +  + +
Sbjct: 8   LADLGPADRTAFFDR--DAGIDAISDDVREIVDRVHEEGDVAVREFTSEFDDVELGNIDI 65

Query: 69  SAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVG 128
           + +    A E L  ++++A+  A  N+  FH AQ       E  PG    +  RP+  VG
Sbjct: 66  T-DACERAYEDLEGDVREAIETAADNVREFHEAQLPEDWRREFGPGRELGRRFRPIERVG 124

Query: 129 LYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP--PIADEILYAAQLCGVQDVFNVGG 186
           +Y+PGGSA   S+ +M   PA +AG   V + +PP   +    L A  + G   V++VGG
Sbjct: 125 VYVPGGSAAYPSSAIMGVVPAVVAGVDHVAVVTPPADELNPVTLAAIHVAGADAVYSVGG 184

Query: 187 AQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSG 246
           AQAIA LA+GTE++ +V KI GPGN +VT AK  V   ++   ID  AGPSEV+V+AD  
Sbjct: 185 AQAIAGLAYGTETITRVQKIVGPGNKWVTAAKAAVRGDVE---IDFLAGPSEVVVVADET 241

Query: 247 ATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNA-- 304
           A PD VA++L++QAEH P++ V+ +T  A+ A  VA AV+ Q     R +  R A     
Sbjct: 242 ADPDLVAAELVAQAEHDPNASVVAVTDDAETADAVAAAVDGQTEARKREDVIRGAFENDA 301

Query: 305 SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASG 364
           S +++ + +++ +  + +Y PEHL I   +   +++ I SAGSVFLG  +P +AGDYASG
Sbjct: 302 SGVLLARSMSEAILFTEEYAPEHLSIIADDEESILERIDSAGSVFLGPNTPVAAGDYASG 361

Query: 365 TNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVT 424
           TNHVLPT G       L +  F +  TVQ LS EG + +  TI TLA AE L AH  +V 
Sbjct: 362 TNHVLPTNGGARVTGGLSIETFLRSTTVQRLSAEGLADIGDTITTLADAEGLEAHAESVR 421

Query: 425 LRVNALKEQA 434
            R+   +   
Sbjct: 422 QRLEDREGDG 431


>UniRef50_Q1AX10 Histidinol dehydrogenase n=1 Tax=Rubrobacter xylanophilus DSM 9941
           RepID=Q1AX10_RUBXD
          Length = 418

 Score =  469 bits (1209), Expect = e-131,   Method: Composition-based stats.
 Identities = 160/429 (37%), Positives = 231/429 (53%), Gaps = 20/429 (4%)

Query: 7   IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTAL 66
           +D     A +  + L RP    S  +   V  +++ V+ RGDEAL EY  +FD      L
Sbjct: 5   LDARGLDAREVVRRLRRPRGFLSREVRAAVRQVVEEVRERGDEALLEYGERFDGVRPDPL 64

Query: 67  KVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVAS 126
           +V  EEI  A   L  EL +A   A++N+  FH  +     ++E + G R  Q  RP+  
Sbjct: 65  RVPREEIERARAALPGELAEAFRTAIENVRRFHERELDRSWELE-RGGARLGQRVRPLRR 123

Query: 127 VGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQDVF 182
            G+Y+PGG     ST++M A PA +AG +++ +C+PP         +L  A L G+ +V+
Sbjct: 124 AGIYVPGGHGAYPSTLVMTAVPAQVAGVEELCVCTPPGPDGRANPRLLAVAGLLGIGEVY 183

Query: 183 NVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVI 242
             GGAQA+AA+AFGTESVP+VDKI GPGN +VT AK +V   +    +D P GPSE++V+
Sbjct: 184 AAGGAQAVAAMAFGTESVPRVDKIVGPGNDYVTAAKLEVFGEV---GVDAPQGPSELVVV 240

Query: 243 ADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL 302
           AD  A P+ VA DL++QAEH   +  +LLTP+  +A  V    E  L+  P         
Sbjct: 241 ADGSARPERVALDLMAQAEHLSGATSVLLTPSGALASGV----EPLLSGRPSEHIT---- 292

Query: 303 NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYA 362
               L++ +DL Q +EISN Y PEH+ +    A   ++ + +AG V +GD SP +  DYA
Sbjct: 293 ----LVLVRDLEQALEISNLYAPEHVHLNCEGAGAALERVEAAGLVAVGDLSPVALSDYA 348

Query: 363 SGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNA 422
           +G +H LPT G     S+LG  DF  R+     S+E    L   +E LA  E    H  +
Sbjct: 349 AGPSHALPTGGTARWASALGTHDFLTRINHMRFSREALRELGPHVERLARMEGFENHAAS 408

Query: 423 VTLRVNALK 431
           V  R    +
Sbjct: 409 VAARREKEE 417


>UniRef50_A3Q131 Histidinol dehydrogenase n=6 Tax=Mycobacterium RepID=A3Q131_MYCSJ
          Length = 474

 Score =  469 bits (1208), Expect = e-131,   Method: Composition-based stats.
 Identities = 157/473 (33%), Positives = 228/473 (48%), Gaps = 48/473 (10%)

Query: 1   MSFNTI-IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFD 59
           ++   I +   + +  Q R  L R  +     +   V  I++ V  RG EA  EY   FD
Sbjct: 6   VTMARIDLRGRTLSTAQLRSALPRGGVDVDAVV-PKVRPIVEAVAERGAEAALEYGEAFD 64

Query: 60  KTTVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQ 119
                +++V AE +A+A   L  +++ A+ VA+      H  Q+         PG    +
Sbjct: 65  GVRPASVRVPAERLASALAELDPDVRAALQVAIDRARAVHADQRRTDTTTTLAPGATVTE 124

Query: 120 VTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPI------ADEILYAA 173
              P+  VGLY+PGG+A   S+V+M   PA  AG   +V+ SPP           IL AA
Sbjct: 125 RWVPLERVGLYVPGGNAVYPSSVVMNVVPAQTAGVDSLVIASPPQADHGGLPHPTILAAA 184

Query: 174 QLCGVQDVFNVGGAQAIAALAFGTESV--------------------------------- 200
            L GV +V+ VGGAQA+A LA+G   +                                 
Sbjct: 185 ALLGVDEVWAVGGAQAVALLAYGGTDIDGTGASGAPGDGTGASGAPGDGTGASGAPGDVT 244

Query: 201 --PKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLS 258
               VD I GPGN +VT AKR    ++    ID  AGP+E+ V+AD  A P  VA+DL+S
Sbjct: 245 ELAPVDMITGPGNIYVTAAKRICRSQV---GIDAEAGPTEIAVLADHTADPVHVAADLIS 301

Query: 259 QAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL--NASRLIVTKDLAQC 316
           QAEH   +  +L+T + D+A  +   + RQL      E    AL    S +++  DL   
Sbjct: 302 QAEHDEMAASVLVTTSPDLADAIDRELRRQLETTVHRERVSTALTGEQSAIVLVDDLDAG 361

Query: 317 VEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTA 376
           V + N Y  EHL IQT +A E+   I SAG++F+G ++P S GDY +G+NHVLPT G   
Sbjct: 362 VRVVNAYAAEHLEIQTVDAAEVAGRIRSAGAIFVGPYAPVSLGDYCAGSNHVLPTAGCAR 421

Query: 377 TCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNA 429
             S L +  F + + V + ++     ++  + TLA AE L AH  AV  R  +
Sbjct: 422 HSSGLSVQTFLRGIHVVDYTEAALKDVSGYVITLAQAENLPAHGEAVRRRFES 474


>UniRef50_A9A5X6 Histidinol dehydrogenase n=2 Tax=Thaumarchaeota RepID=A9A5X6_NITMS
          Length = 420

 Score =  468 bits (1206), Expect = e-130,   Method: Composition-based stats.
 Identities = 152/430 (35%), Positives = 237/430 (55%), Gaps = 15/430 (3%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
             II  N+       Q L +     S    + V  IL +VK  GD A+++Y  KF    V
Sbjct: 1   MKIISINNTE-----QFLKKIGTKDSSKNQKIVKSILKDVKKNGDVAVKKYEKKFS-AKV 54

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQ-PGVRCQQVTR 122
           ++L+VS  +IA+A  ++S E   A+ +A   +    +A +    D+  +  G +  +   
Sbjct: 55  SSLRVSQRDIASAYFKVSKEDISAIKLAKSRLSKAESAVRRQFKDITIKSNGTKLSKSFV 114

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGV 178
           P+ SVG Y+PGG+A   S+ +M   PA IAG K++V+ SPP     I    + AA LCG 
Sbjct: 115 PIDSVGCYVPGGAARYPSSAIMSVVPAKIAGVKRIVVVSPPNSSGNIDPLTIVAADLCGA 174

Query: 179 QDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSE 238
            +++  GG Q+IAAL +GT S+ KV+KI GPG AFVT AK  VS  +   +IDM AGP+E
Sbjct: 175 TEIYKTGGVQSIAALTYGTRSIKKVNKIVGPGGAFVTLAKYLVSNIV---SIDMMAGPTE 231

Query: 239 VLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETA 298
           + ++ DS A  D  A DL+SQAEH  D+    LT +  +A+++  +V  +L ++ R +  
Sbjct: 232 LGIVIDSAADVDVAALDLISQAEHSSDTFCYALTTSNSIAKKIQSSVNSKLKDIQRVKIV 291

Query: 299 RQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESA 358
           + +L ++  I     +  ++I+N   PEHL I ++N ++  + I + G +  G  SP SA
Sbjct: 292 KSSLESNGFIGVCKPSDIIDIANDLAPEHLEIISKNPKKW-NKIKNPGLILYGKNSPSSA 350

Query: 359 GDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTA 418
            DY  G+NH+LPT G+  T  SL + DF K +T  E +K+    ++ +++ L  AE L  
Sbjct: 351 SDYLLGSNHILPTNGFGKTRGSLSVLDFVKLLTKIETTKKDLQKISKSMKNLTLAEGLPN 410

Query: 419 HKNAVTLRVN 428
           H  AV  R+ 
Sbjct: 411 HYEAVRGRLK 420


>UniRef50_D1B7M0 Histidinol dehydrogenase n=2 Tax=Bacteria RepID=D1B7M0_THEAS
          Length = 424

 Score =  468 bits (1205), Expect = e-130,   Method: Composition-based stats.
 Identities = 162/420 (38%), Positives = 236/420 (56%), Gaps = 13/420 (3%)

Query: 19  QLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASE 78
           ++  R + S    ++  V  I+D V   GD A+ E S   D+++  ++ V  EE+  A  
Sbjct: 8   RVKDRASSSDLYGVSHEVRRIIDWVVLHGDRAVLEGSRLHDRSSRDSILVPVEELQRAHR 67

Query: 79  RLSDELKQAMAVAVKNIETFHTAQK---LPPVDVETQPGVRCQQVTRPVASVGLYIPGGS 135
            +  EL +A+  A  N+ETF   QK   +P  + E + GV       PV S G+YIPGGS
Sbjct: 68  SMDPELLEAVRYAASNVETFAQRQKGALMPLEESEVRDGVYLGHRVVPVDSCGIYIPGGS 127

Query: 136 APLFSTVLMLATPASIAGCKKVVLCSP-----PPIADEILYAAQLCGVQDVFNVGGAQAI 190
            PL ST +MLA PA +AG  ++  C+P           +L      GV +V+  GGA A+
Sbjct: 128 YPLISTAVMLAVPARVAGVGRICACTPVRRGTNSPDPSVLGTLYELGVTEVYAAGGAYAV 187

Query: 191 AALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPD 250
           AA+A GTES+P VD I GPGN +VTEAKRQ   ++    ID  AGPSEVL+IA  G  PD
Sbjct: 188 AAMAHGTESIPPVDVIVGPGNKYVTEAKRQCFGKV---GIDFVAGPSEVLIIAQEG-DPD 243

Query: 251 FVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIV 309
           F+A DLL+QAEH PD++ +L+T +  +AR+V + VE  L E+  +  AR +  +   ++ 
Sbjct: 244 FIAWDLLAQAEHDPDAKGVLVTTSPALARQVMDRVETILGEIVTSPVARSSWEDHGEVLA 303

Query: 310 TKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVL 369
            + + + VE SN+  PEHL +  ++    +  + + G++F+G+ S E  GDYASG+NH L
Sbjct: 304 AEGMDEAVEFSNRMAPEHLELMVQDPDRWIPRLRNYGALFIGEHSAEVFGDYASGSNHTL 363

Query: 370 PTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNA 429
           PT G +     L +  F K +T Q +++EG   LA     LA AE L AH+ A   R   
Sbjct: 364 PTAGASRYTGGLWVGTFLKVLTSQRVTREGARELARVSALLAQAEGLMAHRGAALARSRK 423


>UniRef50_B2UMH6 Histidinol dehydrogenase n=3 Tax=Verrucomicrobia RepID=B2UMH6_AKKM8
          Length = 432

 Score =  466 bits (1200), Expect = e-130,   Method: Composition-based stats.
 Identities = 158/436 (36%), Positives = 246/436 (56%), Gaps = 11/436 (2%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
             I   +    ++ ++ + R A+   +S+  TVN I+ +V  RGDEAL +Y+A+FDK  +
Sbjct: 1   MKIYRPSDTCFDEMKRRMNRRAL-PEDSVRDTVNAIIRDVSVRGDEALFDYAARFDKAHL 59

Query: 64  --TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVT 121
             ++L V+  E+A A   + + +K+A+AV++ NI  F    +          GV   +  
Sbjct: 60  DSSSLFVTEAELAEAEAMVEESVKEAIAVSLANIHYFSDRSRRRDWSGVNAQGVEVAERF 119

Query: 122 RPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSP----PPIADEILYAAQLCG 177
            P   VG+YIPGG APL ST +M    A  AG +++V  +P      +   +LYA +  G
Sbjct: 120 LPYDRVGIYIPGGKAPLVSTSIMTGGFAQAAGVREIVAATPCGPDGRVNPALLYALKASG 179

Query: 178 VQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPS 237
             ++  +GGAQAIAALA GTESV  V+KIFGPGN FV EAKRQ+   +   AID+  GPS
Sbjct: 180 ATEIVKIGGAQAIAALALGTESVRPVEKIFGPGNRFVVEAKRQL---VGAVAIDLLPGPS 236

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAET 297
           EV+V+AD  A  +F+A+DLL+Q EHGPDS V+ +T +  +  +V   VERQ A L R   
Sbjct: 237 EVMVLADDTADAEFLAADLLAQGEHGPDSVVVFVTTSKALLEQVEAEVERQAALLSRGSI 296

Query: 298 ARQALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPE 356
            R+ L+  +   +   + + VE+ N + PEHL++ TR+   +++ I +AG+++ G  S  
Sbjct: 297 IREVLDKHAYGFLVSSIQEGVELVNAFAPEHLVLVTRDEEAVLNGIRTAGAIYAGSLSTV 356

Query: 357 SAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERL 416
           + GD+ +G +H LPT G   + S L    FQ+R +V  + +      A  +   A  E L
Sbjct: 357 ACGDFLAGPSHTLPTGGAGKSFSGLRADQFQRRTSVVRMDRNAVLNSAPYVAEFARVEGL 416

Query: 417 TAHKNAVTLRVNALKE 432
            AH +++ +R   +  
Sbjct: 417 DAHNHSIQVRAARVDR 432


>UniRef50_B6A0U7 Histidinol dehydrogenase n=1 Tax=Rhizobium leguminosarum bv.
           trifolii WSM2304 RepID=B6A0U7_RHILW
          Length = 448

 Score =  464 bits (1196), Expect = e-129,   Method: Composition-based stats.
 Identities = 164/443 (37%), Positives = 236/443 (53%), Gaps = 16/443 (3%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
            +I   ++    Q++ LL R     S  I   VN I++ V+  GD AL +++ +FDK  V
Sbjct: 6   VSIHTLSALDDAQRKALLQRTESDLSAFI-DKVNPIIEAVRIDGDAALADFARQFDKAQV 64

Query: 64  --TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDV-ETQPGVRCQQV 120
               L+ + EE +AA   +  EL   +  A  NI  FH  Q    + + ET  GV     
Sbjct: 65  AADQLRATTEEFSAARASIDPELITTLEFAAGNIRHFHEKQMPETLVLHETHRGVLVGDR 124

Query: 121 TRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLC 176
              + SV  Y+P G     S+VLM A PA +AG +KVV+ +PP     +    L AA++ 
Sbjct: 125 WNAIDSVACYVPRGKGSFPSSVLMTAIPAKVAGVRKVVIITPPGPDGTVDPATLVAAEIA 184

Query: 177 GVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGP 236
           GV DVF  GGAQAIAA+AFGT++VPK DK+ GPG+ +V  AK+Q+S  +D  +   PAGP
Sbjct: 185 GVSDVFKCGGAQAIAAVAFGTQTVPKCDKVVGPGSPWVVAAKKQLSSLIDPGS---PAGP 241

Query: 237 SEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELP--R 294
           SE+++ +D     + VA DL  ++EHGPDS V  +T  AD A  VA  V    + +   R
Sbjct: 242 SELIIFSDGSVPAELVALDLCVESEHGPDSSVFFVTDNADFANAVASCVPALWSRMGNIR 301

Query: 295 AETARQALN--ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGD 352
           A+ ++  L+     +++ +  A  +   N Y PEHL +   NA + +     AG + LG 
Sbjct: 302 AQYSKTVLSGPRGGIVIARTRADALAFVNDYAPEHLAVLADNAWQYLACFEHAGEILLGP 361

Query: 353 WSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAA 412
            S  S  ++  G +HVLPT G   T S L + DF KR ++  LSKE +   A+  E LA 
Sbjct: 362 HSAISVANFVLGPSHVLPTGGAAKTTSPLSVFDFLKRTSIASLSKEAYGGFAAHAERLAR 421

Query: 413 AERLTAHKNAV-TLRVNALKEQA 434
            E    H NAV T+R  AL+  A
Sbjct: 422 YEGFDGHANAVSTIRDEALRSAA 444


>UniRef50_B0S9F2 Histidinol dehydrogenase n=6 Tax=Leptospira RepID=HISX_LEPBA
          Length = 430

 Score =  464 bits (1195), Expect = e-129,   Method: Composition-based stats.
 Identities = 164/427 (38%), Positives = 235/427 (55%), Gaps = 11/427 (2%)

Query: 11  SCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSA 70
              +++     ++ A     + T  +  IL++V+ +GD+AL  Y+  FD   ++ L +  
Sbjct: 9   DRNSKELYSRFLQGAREDLTTATDRILPILESVRTQGDQALFSYTEMFDGIKLSQLTIDP 68

Query: 71  EEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLY 130
           ++I      + ++ K+A   A  NIE FH  QK      +   G R      P+ S+ +Y
Sbjct: 69  KKIKT---NVDEKTKEAFLRAKSNIEAFHMEQKRESWS-KVIDGNRLGVKYTPIPSLAVY 124

Query: 131 IPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIA--DEILY-AAQLCGVQDVFNVGGA 187
            PGG A   S+VLM   PA IAG   + L +PP      EIL   AQ+  +  +  VGGA
Sbjct: 125 APGGKALYPSSVLMGIIPAKIAGVPSIQLITPPQKDGIPEILVWLAQIMDIDRIVTVGGA 184

Query: 188 QAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGA 247
           Q IAA A+GTESVPK + I GPGNA+V  AK  +S +     I+ PAGPSEV +IAD  A
Sbjct: 185 QGIAAAAYGTESVPKSEFIVGPGNAYVAAAKSYLSGQ-GLIGIESPAGPSEVCIIADENA 243

Query: 248 TPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQA--LNAS 305
            P ++A D+LSQAEHG DS  ILLT    +A+RV+E +E   +E P+    +Q      S
Sbjct: 244 NPKWIACDMLSQAEHGEDSSAILLTTDLTLAKRVSEELEIAFSERPKRLQMKQTAIYENS 303

Query: 306 RLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGT 365
            ++V   L  C+  SN+  PEHL IQT++   +   I  AGSVFLG +SP + GDY SGT
Sbjct: 304 SILVFPTLDDCIWFSNELAPEHLEIQTKDYESVFAKIEHAGSVFLGPYSPVAMGDYISGT 363

Query: 366 NHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERL-TAHKNAVT 424
           NH+LPT   +   SSLG+  F KR+T QE++KE    L   ++ ++  E L   H  +V 
Sbjct: 364 NHILPTARGSRIYSSLGVDTFLKRVTFQEVTKESLENLYPFVKLMSELEGLDEEHGTSVK 423

Query: 425 LRVNALK 431
           +R    +
Sbjct: 424 VRTRQFQ 430


>UniRef50_D2R570 Histidinol dehydrogenase n=1 Tax=Pirellula staleyi DSM 6068
           RepID=D2R570_9PLAN
          Length = 454

 Score =  463 bits (1193), Expect = e-129,   Method: Composition-based stats.
 Identities = 159/403 (39%), Positives = 227/403 (56%), Gaps = 12/403 (2%)

Query: 33  TRTVNDILDNVKARGDEALREYSAKFDKTTVTA--LKVSAEEIAAASERLSDELKQAMAV 90
           T  V  I  +V+ RG  A+ +YS K D+  +T   ++VS  E+ AA          A+A 
Sbjct: 57  TEVVETICRDVRERGIAAVLDYSKKLDRADLTPETIRVSQAELDAAHAAADPAFLAAIAR 116

Query: 91  AVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPAS 150
             +NI  F TA     V+V  + GV  +Q  +P+  +G+ +PGG+A   STVLM A PA 
Sbjct: 117 IQQNILEFQTAILHKEVEVR-RNGVVLRQRYQPLERIGICVPGGAAAYPSTVLMTAVPAQ 175

Query: 151 IAGCKKVVLCSPPPI----ADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKI 206
            AG  ++V+ +PP        ++L   +  GV +V+ +GGAQ +AALA+G E +PKVDKI
Sbjct: 176 AAGVSQIVVIAPPTDFGANNRDVLATCKAIGVTEVYRMGGAQGVAALAYGVEGIPKVDKI 235

Query: 207 FGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDS 266
            GPGN FV  AKR V   +D   ID  AGPSEV+VI+D     DF A+DLL+QAEH P +
Sbjct: 236 VGPGNLFVALAKRHVYGEVD---IDSIAGPSEVVVISDETTRADFTAADLLAQAEHAPGA 292

Query: 267 QVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVEISNQYGP 325
             IL+T +          +ER +  + R+E   Q+L +   LI+     +   ++++  P
Sbjct: 293 -SILITWSRTALEATKRELERLVQTISRSELTLQSLRDFGCLILVDSPEEACRVTSEIAP 351

Query: 326 EHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLAD 385
           EHL I T NA  L+  I +AG+ FLG++SP + GDYA+G +HVLPT G     S L    
Sbjct: 352 EHLHIATENAGALLAKIRNAGATFLGNYSPVALGDYAAGPSHVLPTGGTARWASGLSANH 411

Query: 386 FQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVN 428
           F +  +V + S E    +A  I+ LA  E LTAH+ +V LRV 
Sbjct: 412 FLRSSSVIDYSAEALRDIAPAIQMLADKEGLTAHRLSVDLRVE 454


>UniRef50_Q2HFX2 Putative uncharacterized protein n=1 Tax=Chaetomium globosum
           RepID=Q2HFX2_CHAGB
          Length = 817

 Score =  463 bits (1193), Expect = e-129,   Method: Composition-based stats.
 Identities = 188/421 (44%), Positives = 245/421 (58%), Gaps = 34/421 (8%)

Query: 24  PAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALK--------VSAEEIAA 75
           P  +A E IT  V D+    +   DEALR  S K   T +  +         V       
Sbjct: 419 PKEAAPERITMKVFDMATASRKELDEALRRPSQKSSDTIMKIITPIIDDTSPVLKAPFPE 478

Query: 76  ASERLSDELKQAMAVAVKNIETFHTAQKL-PPVDVETQPGVRCQQVTRPVASVGLYIPGG 134
           +  +L  E  +AM V+ +NI  FH AQK   P+ VET PGV C + +RP  +VGLY+PGG
Sbjct: 479 SLMQLPTETIKAMDVSFENIRKFHAAQKEEKPLQVETIPGVVCSRFSRPPEAVGLYVPGG 538

Query: 135 SAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVFNVGGAQAIAALA 194
           +A L ST  ML  PA +A CKK+VL SPP                       + A+AA+A
Sbjct: 539 TAVLPSTAFMLGVPAMVAACKKIVLASPPR----------------------SDAVAAMA 576

Query: 195 FGTESVPKVDKIFGPGNAFVTEAKRQVSQRLD-GAAIDMPAGPSEVLVIADSGATPDFVA 253
           +GTESV KVDKI GPGN FVT AK  VS   + G  IDMPAGPSEVLVIAD  A P FVA
Sbjct: 577 YGTESVSKVDKILGPGNQFVTAAKMFVSNDTNAGVGIDMPAGPSEVLVIADKDANPAFVA 636

Query: 254 SDLLSQAEHGPDSQVILLTPAADMAR--RVAEAVERQLAELPRAETARQALNASRLIVTK 311
           SDLLSQAEHG DSQVIL+      A+   + + V +Q   LPR +  R ++  S  +  K
Sbjct: 637 SDLLSQAEHGVDSQVILIAIDLTDAQLLAIEDEVHKQAMALPRVDIVRGSIAHSLTVRVK 696

Query: 312 DLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPT 371
            + + +EISNQY PEHLI+Q ++A  +VD + +AGSVF+G+W+PES GDY++G NH LPT
Sbjct: 697 TVDEAMEISNQYAPEHLILQIKDAESVVDKVMNAGSVFIGEWTPESVGDYSAGVNHSLPT 756

Query: 372 YGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNALK 431
           YGY    S + LA F K +T   L+ EG   +   +  LA  E L AH+ AV++R+  + 
Sbjct: 757 YGYAKQYSGVNLASFVKHITSSNLTAEGLRNVGEAVMQLAKVEELEAHRRAVSIRLAHMD 816

Query: 432 E 432
           +
Sbjct: 817 Q 817


>UniRef50_Q3IQR5 Histidinol dehydrogenase n=10 Tax=Halobacteriaceae RepID=HISX_NATPD
          Length = 422

 Score =  463 bits (1191), Expect = e-129,   Method: Composition-based stats.
 Identities = 169/423 (39%), Positives = 237/423 (56%), Gaps = 11/423 (2%)

Query: 10  NSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVS 69
              + E +  L  R   +  E    +V DI+  V+  GD ALR Y+ +FD   +  L V+
Sbjct: 7   ADLSPEARAALFER--DAGIEDARESVRDIIGRVREEGDVALRSYAKEFDDVDIGTLAVT 64

Query: 70  AEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGL 129
            +E   A + L D+L+ A+  A +NI TFH  Q       E   G    +  RP+  VG+
Sbjct: 65  -DEAERAYDDLDDDLRDAIETAAENIRTFHERQVPDDWR-EQFDGRELGRRYRPLERVGV 122

Query: 130 YIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP--PIADEILYAAQLCGVQDVFNVGGA 187
           Y PGG+A   S+VLM   PA +AG   V + +PP   +    L AA + G   V+ VGGA
Sbjct: 123 YAPGGTAAYPSSVLMGVIPAVVAGVDHVAVATPPAEELPAATLAAAHVAGADAVYQVGGA 182

Query: 188 QAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGA 247
           QAIAALA+GTESV  V K+ GPGN +VT AK +V   ++   ID  AGPSE+LV+ D  A
Sbjct: 183 QAIAALAYGTESVSAVQKVVGPGNRWVTAAKAEVRGDVE---IDFLAGPSELLVVCDDTA 239

Query: 248 TPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNA--S 305
            P+ +A+D+++QAEH P++ V+ ++     A  VA+A ERQ     R E    AL    S
Sbjct: 240 DPELIAADMVAQAEHDPNASVVCVSDDEATAEAVADACERQATARERTEAIESALENDAS 299

Query: 306 RLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGT 365
            ++  + +++ V  + +Y  EHL I   +   L+D I SAGSVFLG +SP + GDYASGT
Sbjct: 300 AVLCARSMSEAVLFAEEYAAEHLSIVAADEEALLDRIDSAGSVFLGGFSPVAVGDYASGT 359

Query: 366 NHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTL 425
           NHVLPT G       L +  F +  TVQ+L ++  S+L  T+ TLA AE L AH  +V  
Sbjct: 360 NHVLPTGGLAKVAGGLSVDHFVRSTTVQKLDEDALSSLRETVTTLARAEGLEAHAESVDK 419

Query: 426 RVN 428
           R +
Sbjct: 420 RFD 422


>UniRef50_Q5JFR5 Histidinol dehydrogenase n=9 Tax=cellular organisms
           RepID=HISX_PYRKO
          Length = 376

 Score =  461 bits (1188), Expect = e-128,   Method: Composition-based stats.
 Identities = 151/401 (37%), Positives = 229/401 (57%), Gaps = 29/401 (7%)

Query: 30  ESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAMA 89
           + +   V +IL++++ RG EALREYS +FD  +    +VS  E   A E + +E K+ + 
Sbjct: 2   KGLEEYVREILEDIRRRGLEALREYSERFDNYS-GPFRVSEGEFEEAEELVPEEDKRVIE 60

Query: 90  VAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPA 149
             ++ +  +H  Q    V++  + G     + RP+  +G+Y+PGG  PL ST++M+  PA
Sbjct: 61  ETMERLWEYHARQ-FRDVELYIKRGSLYGLIYRPIGRIGIYVPGGK-PLPSTLMMVGIPA 118

Query: 150 SIAGCKKVVLCSPPP---IADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKI 206
            IAG +++ + +PP    +   +LY A+L G+++V+ +GG  AIAA+A+G   + +VDKI
Sbjct: 119 RIAGVREIAVTTPPKDGKVNPYVLYVAKLLGIEEVYKLGGVGAIAAMAYGV-GMRRVDKI 177

Query: 207 FGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDS 266
           FGPGN FV EAKRQV   +    ID  AGPSE+ VIAD  A  D+V +DLLSQ EHG DS
Sbjct: 178 FGPGNRFVNEAKRQVFGIV---GIDSLAGPSEIAVIADESADKDYVLADLLSQLEHGKDS 234

Query: 267 QVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQCVEISNQYGPE 326
           +  LLT + ++A               R            +++ ++L +C E +N+  PE
Sbjct: 235 KAWLLTTSRELAD-----------YCSREGI--------EVLLCRNLEECAEKANEIAPE 275

Query: 327 HLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADF 386
           HL I T N  ELVD I +AG+++LG ++P  A DY  G NHVLPT G       L + DF
Sbjct: 276 HLEIITENPEELVDLIENAGAIYLGPYTPVPAADYFLGVNHVLPTGGAARFSGVLTVMDF 335

Query: 387 QKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRV 427
            K +T+  +S+E F A       LA  E + AH+ ++ +R 
Sbjct: 336 MKPITLARVSREEFLAYRRLGMRLAEIEGMEAHRRSLEVRR 376


>UniRef50_C1FAE2 Histidinol dehydrogenase n=1 Tax=Acidobacterium capsulatum ATCC
           51196 RepID=C1FAE2_ACIC5
          Length = 428

 Score =  461 bits (1186), Expect = e-128,   Method: Composition-based stats.
 Identities = 166/433 (38%), Positives = 239/433 (55%), Gaps = 16/433 (3%)

Query: 4   NTIIDWNSCTAEQQRQLLMR---PAISASESITRTVNDILDNVKARGDEALREYSAKFDK 60
             ++      A+  +  L R    + ++ E        I+  V+  GD AL  Y AKFD 
Sbjct: 1   MRVLSTRGRGAQAAQDFLSRLLTGSEASYERALPAAQRIVQGVRRGGDAALLRYRAKFDG 60

Query: 61  -TTVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQ 119
                 L++ AEE+ AA +  + ELK A+  A KNI  F   Q+     ++  PGV   Q
Sbjct: 61  IAASEPLRIPAEEMEAAWKATTAELKAALKQAAKNIRRFAQKQRPRDFTLQMAPGVTAGQ 120

Query: 120 VTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQ 179
              P+ +VG Y+P G  PL ST+LM A PA +AG +++V  SP P A E L AA + GV 
Sbjct: 121 KVIPLEAVGCYVPSGRYPLPSTLLMTAIPAQVAGVRRIVAVSPRP-AKETLAAAHMLGVA 179

Query: 180 DVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEV 239
           + + +GGAQA+AALA+GT S+ +V KI GPGNA+VT AK+ VS       IDM AGP+E+
Sbjct: 180 EFYRIGGAQAVAALAYGTASIERVGKIVGPGNAYVTAAKKAVSFD---CGIDMLAGPTEI 236

Query: 240 LVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETAR 299
            VIA    T + +A+DL++QAEH PD+  IL+T  A + R VA   + +         A+
Sbjct: 237 -VIASENGTVEGIAADLVAQAEHDPDAIAILVTSNAALGRAVAAKTKLRAQS---NAIAK 292

Query: 300 QAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESA 358
           Q++     +I+T+D+ +   ++NQ   EHL   T ++   +  + +AGSVF+G WS +  
Sbjct: 293 QSIAANGAVILTRDVEEARMLTNQLAAEHL---TVDSSADLAWVRNAGSVFVGRWSSQPL 349

Query: 359 GDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTA 418
           GDY SG NH LPT G       L + D+ K +TVQE S  G   L  +   LA AE L  
Sbjct: 350 GDYVSGPNHTLPTSGLARLRGGLSVMDYLKLVTVQEYSATGVRQLGPSAVALAEAEGLVG 409

Query: 419 HKNAVTLRVNALK 431
           H +AV +R+ + K
Sbjct: 410 HADAVRVRLQSAK 422


>UniRef50_Q82AA6 Histidinol dehydrogenase n=29 Tax=Actinobacteridae RepID=HISX_STRAW
          Length = 441

 Score =  461 bits (1186), Expect = e-128,   Method: Composition-based stats.
 Identities = 149/425 (35%), Positives = 228/425 (53%), Gaps = 13/425 (3%)

Query: 12  CTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAE 71
                 R LL R     S ++ + V  I + V  RGD AL +++ KFD   + +++V A 
Sbjct: 13  PEGSALRDLLPRADFDVSAALEK-VRPICEAVHHRGDAALIDFAEKFDGVRLESVRVPAR 71

Query: 72  EIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYI 131
            +A A E+L   ++ A+  +++     H  Q+      +  PG    +   PV  VGLY 
Sbjct: 72  ALADALEQLDPAVRAALEESIRRARLVHREQRRTTHTTQVVPGGSVTEKWVPVDRVGLYA 131

Query: 132 PGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPI------ADEILYAAQLCGVQDVFNVG 185
           PGG +   S+V+M   PA  AG + + L SP            IL A  L GV +V+  G
Sbjct: 132 PGGRSVYPSSVVMNVVPAQEAGVESIALASPAQAEFGGLPHPTILAACALLGVDEVYAAG 191

Query: 186 GAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADS 245
           GA A+A  A+GTES    D + GPGN +V  AKR  + ++    ID  AGP+E+ V+ADS
Sbjct: 192 GATAVAMFAYGTESCAPADMVTGPGNIWVAAAKRYFTGKI---GIDAEAGPTEIAVLADS 248

Query: 246 GATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPR-AETARQALN- 303
            A P  VASDL+SQAEH P +  +L+T + ++A  V + +E Q+A      +    AL  
Sbjct: 249 TADPVHVASDLISQAEHDPLAAAVLVTDSVELADAVEKELEPQVAATKHIDDRIVPALKG 308

Query: 304 -ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYA 362
             S +++   + + + + + YG EHL IQT +A  + D + +AG++F+G W+P S GDYA
Sbjct: 309 RQSAIVLVDGVDEGLRVVDAYGAEHLEIQTADAAAVADRVRNAGAIFIGPWAPVSLGDYA 368

Query: 363 SGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNA 422
           +G+NHVLPT G     S L +  F + + + + +K+  + +A  + TLA AE L AH  A
Sbjct: 369 AGSNHVLPTGGCACHSSGLSVQSFLRGIHIVDYTKDALADVAHHVVTLAEAEDLPAHGAA 428

Query: 423 VTLRV 427
           +  R 
Sbjct: 429 IKARF 433


>UniRef50_C0GVA3 Histidinol dehydrogenase n=1 Tax=Desulfonatronospira thiodismutans
           ASO3-1 RepID=C0GVA3_9DELT
          Length = 436

 Score =  457 bits (1177), Expect = e-127,   Method: Composition-based stats.
 Identities = 132/408 (32%), Positives = 202/408 (49%), Gaps = 8/408 (1%)

Query: 29  SESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAM 88
           +  I   V  +LD+++ RG+ A+RE +AK+D  + T   +  E+       + +++K  +
Sbjct: 15  NSRIREAVTFLLDDIRTRGEPAVREMAAKYDGWS-TDFVLQEEKKERLIAMVPEQVKTDI 73

Query: 89  AVAVKNIETFHTAQKL--PPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLA 146
             A   +  F   Q+      +V   PGVR  Q   PV   G Y+PGG      + +M  
Sbjct: 74  RFAHDQVFNFARMQRQSIQDFEVRPHPGVRLGQRVLPVDVAGCYVPGGRFAHACSAIMSV 133

Query: 147 TPASIAGCKKVVLCSPP---PIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKV 203
             A  AG   VV CSPP    IA  + +A  L G   +  +GG Q +AA+A+G  +    
Sbjct: 134 ATAKAAGVPFVVACSPPREESIAPAVAFAMDLAGADVILELGGVQGVAAMAYGYFTNRPA 193

Query: 204 DKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHG 263
           D + GPGNA+V EAK  ++       ID+ AGP+E  +IAD  A P  +A DL+SQAEHG
Sbjct: 194 DILVGPGNAYVAEAKALLAGD-GTCGIDVYAGPTESAIIADRSADPMTIAIDLVSQAEHG 252

Query: 264 PDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVEISNQ 322
           PDS V L T   D+A +V   V R +A++P     + A  +   +I+  +  +   + + 
Sbjct: 253 PDSPVWLFTDCRDLAYQVLNLVPRVIADMPDPHVPKTAWADFGEIILCNNRDEICRVCDT 312

Query: 323 YGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLG 382
           Y PEH+ I   +    ++S+ S GS+FLG+ S  + GD  SGTNH+LPT         L 
Sbjct: 313 YAPEHVQILAADPDWWLESLRSYGSLFLGEGSSVAHGDKCSGTNHILPTRKAAQHSGGLS 372

Query: 383 LADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNAL 430
           +  F K  T QE+  E     ++    L+  E +  H  +   R+   
Sbjct: 373 VHKFLKISTYQEIDTEASKRFSAVASRLSRVEGMEGHARSCDWRLTKF 420


>UniRef50_Q5YYQ0 Histidinol dehydrogenase n=8 Tax=Actinomycetales RepID=HISX_NOCFA
          Length = 445

 Score =  456 bits (1175), Expect = e-127,   Method: Composition-based stats.
 Identities = 159/437 (36%), Positives = 233/437 (53%), Gaps = 17/437 (3%)

Query: 7   IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTAL 66
           +   + +  + R  L R  +    S+   V  +++ V+ RG  A  E+  KFD      +
Sbjct: 12  LRGRTPSTAELRAALPRGGVDVD-SVLHHVRPVVEAVRERGAAAALEFGEKFDGVVPATV 70

Query: 67  KVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVAS 126
           +V A E+A A + L   ++ A+  ++      H  Q+      E  PG    +   PVA 
Sbjct: 71  RVPAAELARALDELDPAVRAALEESIARARRVHADQRRTDTTTEVVPGGTVTERWVPVAR 130

Query: 127 VGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPI------ADEILYAAQLCGVQD 180
           VGLY+PGG+A   S+V+M   PA  AG   +V+ SPP           IL AA L GV++
Sbjct: 131 VGLYVPGGNAVYPSSVVMNVVPAQTAGVGSLVVASPPQANFGGLPHPTILAAAALLGVEE 190

Query: 181 VFNVGGAQAIAALAFG---TESVP--KVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAG 235
           V+ VGGAQA+A L++G   T+  P   VD I GPGN +VT AKR     +    ID  AG
Sbjct: 191 VWAVGGAQAVALLSYGGTDTDGAPLDPVDLITGPGNIYVTAAKRLCRGLV---GIDAEAG 247

Query: 236 PSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRA 295
           P+E+ ++AD+ A P  VA+DL+SQAEH   +  +L+T +  +A  V  A+  QLA +  A
Sbjct: 248 PTEIAILADATADPAHVAADLISQAEHDVLAASVLVTDSVALADAVDAALTAQLAVVKHA 307

Query: 296 ETARQAL--NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDW 353
           E  R AL    S  ++  D+ Q + + + Y  EHL IQT +A  +   + SAG+VF+G +
Sbjct: 308 ERVRTALTGKQSGTVLVDDITQGLRVVDAYAAEHLEIQTADASAVAARVRSAGAVFVGPY 367

Query: 354 SPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAA 413
           +P S GDY +G+NHVLPT G     S L +  F + + V E ++     +A  +  LA A
Sbjct: 368 APVSLGDYCAGSNHVLPTAGCARHSSGLSVQTFLRGIHVVEYTEAALKDVAGHVVALADA 427

Query: 414 ERLTAHKNAVTLRVNAL 430
           E L AH  AVT+R  AL
Sbjct: 428 EDLPAHGQAVTVRFEAL 444


>UniRef50_Q1D4L9 Histidinol dehydrogenase n=2 Tax=Cystobacterineae
           RepID=Q1D4L9_MYXXD
          Length = 437

 Score =  456 bits (1173), Expect = e-126,   Method: Composition-based stats.
 Identities = 172/423 (40%), Positives = 243/423 (57%), Gaps = 9/423 (2%)

Query: 9   WNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKV 68
            ++   E  R+LL R A  +   +   V +I+  V+A GD+AL E + +FD+  +TAL+V
Sbjct: 16  LSALAREDVRRLLDR-ATGSDARVALRVREIIARVRAEGDQALFELARQFDRVELTALEV 74

Query: 69  SAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVG 128
             E  AAA   L   ++ A+A A +NI   H  QK   V+VET+PGV   +   P+  VG
Sbjct: 75  PREVCAAALAGLEPSVRDALARAARNIALAHAPQKPQWVEVETEPGVLVGRRPDPLGRVG 134

Query: 129 LYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQDVFNV 184
           +Y PGG A   S+VLM   PA +AG  +V++CSPP         +L AA L G   VF++
Sbjct: 135 VYAPGGRAVYPSSVLMGVVPAKVAGVGEVIVCSPPGPDGLPHPSVLAAASLAGADRVFSL 194

Query: 185 GGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIAD 244
           GGA A+AA+A GTESVP+VD+I GPGNA+V EAK QV   +   AI+ PAGPSE+LV+AD
Sbjct: 195 GGAGAVAAMAHGTESVPRVDRIVGPGNAYVAEAKLQV---VGAVAIEAPAGPSEILVVAD 251

Query: 245 SGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-N 303
             A P  VA ++L+QAEH P++  + L     +A  +A  VERQ     R E    AL +
Sbjct: 252 DTANPAAVAREMLAQAEHDPEAACVTLALGDALADAIAAEVERQAERAKRWEIVTSALGS 311

Query: 304 ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYAS 363
              ++    L +       + PEHL+I T + RE +  + +AG+VFLG+ S  + GDY +
Sbjct: 312 RGAVLTVASLEEAWPFVADFAPEHLLIATASPREDLGQVRNAGTVFLGERSSVAYGDYMT 371

Query: 364 GTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAV 423
           G+NHVLPT G     S L L DF +  T Q ++    ++LA  +  LA +E L AH +A 
Sbjct: 372 GSNHVLPTAGLARAYSGLNLLDFYRWTTYQRVAPTAAASLAEDVGRLADSEGLFAHADAA 431

Query: 424 TLR 426
              
Sbjct: 432 RAW 434


>UniRef50_B8E2C3 Histidinol dehydrogenase n=1 Tax=Dictyoglomus turgidum DSM 6724
           RepID=B8E2C3_DICTD
          Length = 417

 Score =  455 bits (1171), Expect = e-126,   Method: Composition-based stats.
 Identities = 126/411 (30%), Positives = 214/411 (52%), Gaps = 19/411 (4%)

Query: 21  LMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA--LKVSAEEIAAASE 78
           L+R   S  + + + V+ I++ ++ +GD AL  +S KFD         K+S  EI     
Sbjct: 14  LLRMEESKVKEVEKEVDFIVEEIRTKGDLALHNFSLKFDNYDSKKYGFKISVPEID---- 69

Query: 79  RLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPL 138
            LS++   A+ V ++ ++ ++  +       +    +   Q+  PV SV LY+PGG A  
Sbjct: 70  -LSNDFATAIKVMIERVKNYYIHEYKNSWFYKDGESI-LGQLIVPVDSVLLYVPGGKASY 127

Query: 139 FSTVLMLATPASIAGCKKVVLCSPPPI--ADEILYAAQLCGVQDVFNVGGAQAIAALAFG 196
            STV+M   PA IAG K + + +PP       +LY  +L G+++++ +GGA AI+A A+G
Sbjct: 128 PSTVVMGLIPAMIAGVKNLYVTTPPSKREDRNLLYTLRLLGIKELYVLGGAHAISAFAYG 187

Query: 197 TESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIAD---SGATPDFVA 253
           TES+PKVD I GPGN +V  AK++V   ++   ID   GPSE+LV  +          + 
Sbjct: 188 TESIPKVDMIIGPGNLYVALAKKRVFGDVN---IDGIFGPSEILVWINYRGKDLNLRKIV 244

Query: 254 SDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDL 313
            D L+Q EH P  +  ++ P  ++  +V   ++ ++    R +  ++A+  S LI+ +D 
Sbjct: 245 CDFLAQLEHSPYDRGWMILP-EELLDKVMGLIKEEVEGSGRGDILKEAIKNSFLIIEEDE 303

Query: 314 AQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYG 373
            + + + NQ  PEHL I   +    +  I +AG++F+   S    GD+ +G +H+LPT G
Sbjct: 304 ERAINLINQIAPEHLEIIDFSGERHIPYIKNAGAIFINHSS--IFGDFIAGPSHILPTGG 361

Query: 374 YTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVT 424
                S L +  F KR++  +LS +    LA     +A  E    H+ ++ 
Sbjct: 362 SAKFSSGLSVNSFLKRISFVKLSAKEQKILAEYGSIIAREEGFYMHEKSLR 412


>UniRef50_B5YE85 Histidinol dehydrogenase n=1 Tax=Dictyoglomus thermophilum H-6-12
           RepID=B5YE85_DICT6
          Length = 416

 Score =  454 bits (1170), Expect = e-126,   Method: Composition-based stats.
 Identities = 127/428 (29%), Positives = 216/428 (50%), Gaps = 23/428 (5%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              +I              +R   S  + I + V  I++ VK +GD AL ++S ++D   
Sbjct: 1   MINVIRGKDFDPN-----FLRIEDSKIKEIEKNVEFIIEEVKTKGDLALYDFSLRYDNYD 55

Query: 63  VTA--LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQV 120
                 K++  +I      LS +   A+ V ++ ++ ++  +       +    +   Q+
Sbjct: 56  SRKYGFKINVPDID-----LSTDFAVAIKVMIERVKNYYMHEYKNSWFYKDGESIF-GQL 109

Query: 121 TRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPI--ADEILYAAQLCGV 178
             PV SV LY+PGG A   STV+M   PA IAG K + + +PP       +LY  ++ G+
Sbjct: 110 VVPVDSVLLYVPGGRASYPSTVVMGLVPAIIAGVKNLYVTTPPSKRDDKNLLYTLRILGI 169

Query: 179 QDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSE 238
           ++++ +GGA AI+A A+GTES+PKVD I GPGN +V  AK++V   ++   ID   GPSE
Sbjct: 170 KELYLLGGAHAISAFAYGTESIPKVDMIIGPGNLYVALAKKKVFGDVN---IDGIFGPSE 226

Query: 239 VLVIA--DSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAE 296
           VLV    D       V  D L+Q EH P  +  ++  + ++   + E +++++ +  R +
Sbjct: 227 VLVWVNYDKDLNLRKVVCDFLAQLEHSPYDRGWIIV-SENLVYDLLELIKKEVEDSERGD 285

Query: 297 TARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPE 356
             +++L  S LI+ ++    + + NQ GPEHL I        +  I +AG++F+   S  
Sbjct: 286 ILKESLKNSFLIIEENEKNAINLINQIGPEHLEIIDPFGERYIPYIKNAGAIFINHSS-- 343

Query: 357 SAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERL 416
             GD+ +G +H+LPT G     S L +  F KR++  +LS +    LA    T+A  E  
Sbjct: 344 IFGDFIAGPSHILPTGGSAKFSSGLSVNSFLKRISFVKLSTQDQKILAKYGSTIAREEGF 403

Query: 417 TAHKNAVT 424
             H+ ++ 
Sbjct: 404 YMHEKSLR 411


>UniRef50_O33775 Histidinol dehydrogenase n=12 Tax=Sulfolobaceae RepID=HISX_SULSO
          Length = 398

 Score =  450 bits (1158), Expect = e-125,   Method: Composition-based stats.
 Identities = 139/412 (33%), Positives = 219/412 (53%), Gaps = 23/412 (5%)

Query: 21  LMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERL 80
           L     +    +   V DI+++VK +GD AL E + K DK  +  +K   EE+   + +L
Sbjct: 6   LPNERPNDFSRVIPVVKDIIESVKTKGDNALYELTEKLDKVKIDNIKAREEELKTQASKL 65

Query: 81  SDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFS 140
             ++KQA+  A + ++ FH     P +      G+    + R +  +G+Y+P G     S
Sbjct: 66  DPKVKQAIDTAYEQLKAFHEMLVPPNI-GGGYQGISFGVIWRSIEKIGIYVPSGKYSYPS 124

Query: 141 TVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQDVFNVGGAQAIAALAFG 196
           T+LM   PA +A  K++ + SPP     +   + Y A   GV +V+ +GGAQAIAALAFG
Sbjct: 125 TLLMAGIPAKVAKVKEIYVASPPTQEGTVNPALAYVAIKLGVNEVYKIGGAQAIAALAFG 184

Query: 197 TESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDL 256
           TESV KV KI GPGN +V  AK  VS  +    ID   GP+E+++IAD  A  ++VA D+
Sbjct: 185 TESVKKVYKIVGPGNVYVQAAKYLVSSVV---GIDGIEGPTELVIIADETAKAEYVALDM 241

Query: 257 LSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQC 316
            +QAEHGPD+ ++LL+   ++ RRV E +             +       +I TK+L + 
Sbjct: 242 KAQAEHGPDTYIVLLSNDDELIRRVEEKI-------------KNDKKIYYIIKTKNLDEA 288

Query: 317 VEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTA 376
           +EI+N+  PEHL +  ++A  L+D I +AG++ LG+ +P +  DY +G NH+LPT G+  
Sbjct: 289 IEIANKIAPEHLSLYVKDAYTLMDKIVNAGAISLGN-TPPAIIDYVAGPNHILPTNGWAK 347

Query: 377 TCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVN 428
               + + DF K      + ++    L     +LA  E    H  ++  R  
Sbjct: 348 IRGGITVYDFIKPTMYANV-RDINKQLLEASISLANYEGFIIHGKSIGARYE 398


>UniRef50_Q1IKB6 Histidinol dehydrogenase n=1 Tax=Candidatus Koribacter versatilis
           Ellin345 RepID=Q1IKB6_ACIBL
          Length = 415

 Score =  445 bits (1146), Expect = e-123,   Method: Composition-based stats.
 Identities = 177/426 (41%), Positives = 250/426 (58%), Gaps = 16/426 (3%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKT-T 62
             I+     +       L    ++ +  +   V  I+ +V+  GD ALR Y++K D    
Sbjct: 1   MRILRLEKSSG--LLAKLAARGMADASRVEPVVRKIVVDVRKNGDAALRRYASKLDGLGK 58

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
             AL+VS EE+ +A +    E KQA+  A KNIE F   Q       +   G+   Q+ R
Sbjct: 59  TAALRVSTEELKSAWDATRSEFKQAIRAAAKNIERFARWQMPKSWTRDAGDGIELGQIIR 118

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVF 182
           P+ SVG Y+PGG  PL STVLM   PA +AG ++VV+ SP P A E L AA L GV + +
Sbjct: 119 PIESVGCYVPGGRYPLPSTVLMTVVPARVAGVERVVVVSPNP-ARETLAAAYLLGVGEFY 177

Query: 183 NVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVI 242
            +GGAQA+AALA+GTESV +V KI GPGN FVT AK+ V+      AIDM AGP+E  ++
Sbjct: 178 RIGGAQAVAALAYGTESVERVAKIVGPGNIFVTTAKKLVAFD---CAIDMLAGPTEAAIV 234

Query: 243 ADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL 302
           +       F+A+DL++QAEH P++ V   T +  +A  V + V    A   +   AR+AL
Sbjct: 235 S-ERGNARFIAADLVAQAEHDPETMVAFFTTSPSLADAVKKQVALLAA---KNTIARKAL 290

Query: 303 N-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDY 361
                + V +D+AQ +E +NQ+  EHL +      +L+++++SAGSVF+GD+S +S GDY
Sbjct: 291 ATRGYIFVAQDIAQAMEAANQFASEHLTVD----EDLLETVSSAGSVFVGDYSAQSFGDY 346

Query: 362 ASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKN 421
           ASG NHVLPT G       L + D+ K +TVQ++S++G  ALA   ETLAAAE L AH  
Sbjct: 347 ASGPNHVLPTGGLARVRGGLSVLDYVKIITVQKISRKGLRALAPIAETLAAAEGLVAHGQ 406

Query: 422 AVTLRV 427
           +V +R 
Sbjct: 407 SVAIRR 412


>UniRef50_Q46N53 Histidinol dehydrogenase 2 n=50 Tax=root RepID=HISX2_RALEJ
          Length = 436

 Score =  444 bits (1144), Expect = e-123,   Method: Composition-based stats.
 Identities = 136/418 (32%), Positives = 213/418 (50%), Gaps = 13/418 (3%)

Query: 22  MRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLS 81
            +   + + +  + V ++L  ++ARG +A+R+Y+ + D  +   + ++ ++I   ++ + 
Sbjct: 9   EKTPQTETATAQKVVTEMLAEIQARGKDAVRQYAKQLDGWS-GDIVLTPDQIREQTKDVP 67

Query: 82  DELKQAMAVAVKNIETFHTAQKL--PPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLF 139
             ++  +  A++ +  F  AQ+       VE  PGV   Q   PV  VG Y P G     
Sbjct: 68  AGVRADIDFAIRQVTDFALAQRESLKEFSVELHPGVTAGQRVLPVNVVGCYAPAGRYAHI 127

Query: 140 STVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQDVFNVGGAQAIAALAF 195
           ++  M    A  AG K VV CS P     I   +LYA Q  G   +  +GG QAIA++A+
Sbjct: 128 ASAYMGVATAKAAGVKTVVACSSPFRGQGIHPHVLYAFQAAGADVIMALGGVQAIASMAY 187

Query: 196 GTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASD 255
           G  +    D + GPGN FV EAKR +  ++    ID+ AGPSEV VIAD  A P  VASD
Sbjct: 188 GLFTGKPADVVVGPGNKFVAEAKRSLYGQV---GIDVFAGPSEVAVIADETADPAIVASD 244

Query: 256 LLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPR--AETARQAL-NASRLIVTKD 312
           L+ QAEHG +S   L T + D+A RV   V   +A+LP    + A  A  +   +I+   
Sbjct: 245 LVGQAEHGHESPAWLFTTSRDLADRVMALVPELIAKLPPTARDAATAAWRDYGEVILCGT 304

Query: 313 LAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTY 372
             + VEIS++Y  EHL + T +    + ++T  GS+FLG+ +  + GD  SG NHVLPT 
Sbjct: 305 REEVVEISDRYASEHLEVHTADLDWWLANLTCYGSLFLGEETTVAFGDKTSGPNHVLPTK 364

Query: 373 GYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNAL 430
           G       L +  F K +T Q++++E    +      ++  E + AH      R+   
Sbjct: 365 GAARYSGGLSVHKFMKTLTWQQMTREATRQIGQVTARISRLEGMEAHARTADDRMAKY 422


>UniRef50_C7LZ86 Histidinol dehydrogenase n=1 Tax=Acidimicrobium ferrooxidans DSM
           10331 RepID=C7LZ86_ACIFD
          Length = 432

 Score =  441 bits (1134), Expect = e-122,   Method: Composition-based stats.
 Identities = 156/434 (35%), Positives = 223/434 (51%), Gaps = 9/434 (2%)

Query: 1   MSFNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDK 60
           M+  T++D    T   +R  L        E     V +I+ +V+  GD AL + + +FD 
Sbjct: 1   MASLTLVDLRETTGALRRDDLP-GVALPVEGPRALVREIVQSVRTGGDGALADLTERFDG 59

Query: 61  TTVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQV 120
               AL +  E +AAA ERL   L +A+ VA   +   + A++     +    G+  ++ 
Sbjct: 60  VRPRALVLGREAMAAAYERLDRRLAEALRVARDRVREAYEAERPAASSL-VADGIEVRRR 118

Query: 121 TRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLC 176
             PV   G Y+PGG A   S+V+  AT A +AG + VV+ +PP     + D  L A  L 
Sbjct: 119 IVPVERAGCYVPGGQARYPSSVVHTATVARVAGVRDVVVATPPLPDGGLDDATLAACHLA 178

Query: 177 GVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGP 236
           GV  V   GGAQA+AALA+GTES+ +VD I GPGN FV+ AK++V+  +        AGP
Sbjct: 179 GVDTVLLAGGAQAVAALAYGTESLERVDVIVGPGNLFVSLAKQEVAADVGVPG--AFAGP 236

Query: 237 SEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAE 296
           SEV+V+AD    P   A D+  QAEHGP     L+T  A  A +V E +   +   PR  
Sbjct: 237 SEVVVVADGSLEPRVAAIDVAVQAEHGPHGLAWLVTWDARWAEQVLEELAAYVEASPRRA 296

Query: 297 TARQALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSP 355
                L     L + +D  Q   +++   PEHL +    A    D +  AG VF+G  + 
Sbjct: 297 QLESTLEAHGYLALVRDRDQARLVADAIAPEHLELLYDQAVRDADRVRHAGVVFVGRAAS 356

Query: 356 ESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAER 415
            + GDY +G +HVLPT G     S LGL DFQ+R+ V E+  E  S L   +E LA AE 
Sbjct: 357 AAFGDYVAGPSHVLPTAGTARFASVLGLEDFQRRLHVVEVHDEALSRLGWAVEALADAEG 416

Query: 416 LTAHKNAVTLRVNA 429
           L AH +++ +R  A
Sbjct: 417 LVAHADSIRIRREA 430


>UniRef50_A9G5W4 HisD protein n=1 Tax=Sorangium cellulosum 'So ce 56'
           RepID=A9G5W4_SORC5
          Length = 460

 Score =  438 bits (1128), Expect = e-121,   Method: Composition-based stats.
 Identities = 164/451 (36%), Positives = 226/451 (50%), Gaps = 28/451 (6%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              I    S   E     L         ++T  V +I+DNV+  G  A+  Y  KF++ T
Sbjct: 1   MLPIYIEGSPQFESTLSALRTRGTGDLANVTPAVTEIIDNVRRGGTSAVLGYIEKFERRT 60

Query: 63  VTAL-KVSAEEIA------AASERLSDELKQAMAVAVKNIETFHTAQK------------ 103
             AL + +  E         A  RLS E++ A+  A   I  +H  Q+            
Sbjct: 61  SKALVRHAGPEAEGGFGGAEALARLSPEVRAALETAAARIARYHERQRDAGDLGPANVTA 120

Query: 104 ----LPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVL 159
               L       + GV      RP+  VG+Y PGG A   S+VLM A PA IAG +++VL
Sbjct: 121 NGPALQAGFSYEEEGVLLGMRVRPLRRVGVYAPGGKARYPSSVLMSAIPARIAGVREIVL 180

Query: 160 CSPPPIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKR 219
            SP    D  L AA L GV  + + GGAQAIAA+A+G   +  VDKI GPGNA+V  AK+
Sbjct: 181 ASP-SADDATLAAAHLSGVTTLLDSGGAQAIAAMAYGLPELAPVDKIVGPGNAYVACAKK 239

Query: 220 QVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMAR 279
            V   +   +ID   GPSE+L +AD  A P  VA+DLLSQAEH   S  +L T +A +A 
Sbjct: 240 LVFGDV---SIDGITGPSEILALADESADPRLVAADLLSQAEHDEASYALLATTSAKLAE 296

Query: 280 RVAEAVERQLAELPRAETARQALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNAREL 338
            VA  ++  L EL R    + +L+  +  +V    A+  EI++Q   EH+     +A  L
Sbjct: 297 AVARELDAALPELTRRAIVQASLSTHAAALVVGSRARLAEIADQLAVEHVAFHVADAEGL 356

Query: 339 VDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKE 398
              I + G+  LGD +P +AGDY +G +HVLPT G     + LG+ DF  R ++   S  
Sbjct: 357 FSEIGTLGAALLGDLTPVAAGDYLAGPSHVLPTGGSARFGAPLGVYDFVTRASLIRYSSA 416

Query: 399 GFSALASTIETLAAAERLTAHKNAVTLRVNA 429
              A    IE LA AE L AH  AV+LR+ +
Sbjct: 417 ALRAQGPIIEKLALAEGLQAHARAVSLRLAS 447


>UniRef50_Q0AP81 Histidinol dehydrogenase, Histidinol-phosphatase n=10 Tax=Bacteria
           RepID=Q0AP81_MARMM
          Length = 631

 Score =  436 bits (1123), Expect = e-121,   Method: Composition-based stats.
 Identities = 188/434 (43%), Positives = 259/434 (59%), Gaps = 6/434 (1%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              I++W   + E + + L RPA S+S        DI+D ++ +GDEA+R Y+ + D   
Sbjct: 1   MLDILNWTDASPEARTRALTRPASSSSAGPAA--RDIVDAIRDQGDEAVRAYAKRLDGYA 58

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
               +V    + AA   L     +A+  A   +  FH  Q      VET PGV   +   
Sbjct: 59  PGDFRVPEGVLKAARAALDPRDAEAIKAAADAVRRFHVQQGYRGYSVETWPGVTASRRAT 118

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGV 178
           PV +  LY+P GSAPL S+++MLA PA +AG  ++V+ +PP     +   +L AA L G+
Sbjct: 119 PVDTAALYVPAGSAPLVSSLIMLAIPAQLAGVPRIVVVAPPAGDGGVNPALLAAADLLGL 178

Query: 179 QDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSE 238
            +V+ +GGAQAIAAL+FG   +P+ DKIFGPGNA+V  AK  VS    G A+D+PAGPSE
Sbjct: 179 DEVYAIGGAQAIAALSFGAAGLPRADKIFGPGNAYVAAAKAYVSSLPGGPAVDLPAGPSE 238

Query: 239 VLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETA 298
           V+VIAD  A PD VASDLLSQAEH P +QV+L+   A  A RV  +V + L +LPRA  A
Sbjct: 239 VMVIADETADPDLVASDLLSQAEHDPSAQVMLVCFDAATADRVTASVAKLLEDLPRAAIA 298

Query: 299 RQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESA 358
           R+AL AS ++V   +   ++I+N Y PEHLI+Q  +A  L+  +  AGS+F+G W+PE+A
Sbjct: 299 REALAASAILVCDSVDDAIDIANIYAPEHLILQAESAERLLAGVRHAGSIFVGAWTPEAA 358

Query: 359 GDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTA 418
           GDYA+G NH LPT G       + +  FQK  T+   S+ G  ALA T+E LAA E+L A
Sbjct: 359 GDYAAGPNHTLPTAGAARAHGGVSVESFQKTTTILRASEAGAVALAPTVERLAALEQLDA 418

Query: 419 HKNAVTLRVNALKE 432
           H  A+ LR      
Sbjct: 419 HGLAMRLRRERANT 432


>UniRef50_A0R401 Histidinol dehydrogenase n=2 Tax=Actinomycetales RepID=A0R401_MYCS2
          Length = 451

 Score =  431 bits (1109), Expect = e-119,   Method: Composition-based stats.
 Identities = 152/419 (36%), Positives = 228/419 (54%), Gaps = 12/419 (2%)

Query: 24  PAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDE 83
           P       +   V+ +L +++ RG +A+R Y+ + D  +   L++ A+E+  + + L  +
Sbjct: 25  PPAQRDPKVVERVSQMLLDIERRGLDAVRAYARELDGWS-GPLEIGADELRKSGDALPAD 83

Query: 84  LKQAMAVAVKNIETFHTAQKLP--PVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFST 141
           L++A+ +  +    F  AQ+      ++E  PGV       PV  VG Y+P G  PL ++
Sbjct: 84  LREALELGYERTNRFAVAQRARLTDFEIELAPGVTGGVQYVPVNRVGAYLPAGRFPLLAS 143

Query: 142 VLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQDVFNVGGAQAIAALAFGT 197
             M    A  AG   V+ C+PP         +LY A L     VF VGG QA+ A+AFG 
Sbjct: 144 AFMTVGVAKAAGVPTVLACTPPSGEHGAHPAVLYGAYLSRADSVFAVGGVQALGAMAFGL 203

Query: 198 ESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLL 257
                VD + G GNAFVTEAKRQ+  R+    ID+ AGPSEV V+AD  A P++VA+DLL
Sbjct: 204 IGDGPVDMLVGAGNAFVTEAKRQLFGRV---GIDLLAGPSEVAVLADETADPEWVAADLL 260

Query: 258 SQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQC 316
            QAEHGP+S   L+T +  + RRV EA++RQL  L   E A  A  +   ++V  D  Q 
Sbjct: 261 GQAEHGPNSPAALITTSETLGRRVIEAIDRQLETLATREVAGPAWRDFGSVLVASDAEQA 320

Query: 317 VEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDY-ASGTNHVLPTYGYT 375
             I++  GPEHL +QT +    +  + + GS+FLG WS  +  D   +GTNHVLPT    
Sbjct: 321 AAIADVLGPEHLEVQTADDDYFLKRLRNYGSLFLGRWSTVAYSDKGIAGTNHVLPTGKTA 380

Query: 376 ATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNALKEQA 434
              + L ++ F K +T Q  ++E  +ALA  +E ++A E L AH+   T+R+  +   +
Sbjct: 381 RYNAGLSVSRFVKPLTYQRAAREATAALAPAVERISAFEGLAAHEATATIRIEEIGRDS 439


>UniRef50_C7RAI8 Histidinol dehydrogenase n=1 Tax=Kangiella koreensis DSM 16069
           RepID=C7RAI8_KANKD
          Length = 405

 Score =  426 bits (1097), Expect = e-118,   Method: Composition-based stats.
 Identities = 134/421 (31%), Positives = 216/421 (51%), Gaps = 22/421 (5%)

Query: 10  NSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVS 69
              +  +      RP ++ S  + + V  +L  ++  GD A+   S +FD      +++ 
Sbjct: 2   ADKSYIECASNWKRPNLTQSPELFQQVAKLLKEIETGGDLAIDNLSKRFDGFQPRKIELR 61

Query: 70  AEEIAAASERLSDELKQAMAVAVKNIETFHTAQK--LPPVDVETQPGVRCQQVTRPVASV 127
                     L  +L  ++  A + IE F   QK  L P  +E   GV   Q   P+ ++
Sbjct: 62  PYRDYE----LEPQLLNSIEQAAQRIEAFCQLQKGSLQPQQIEEASGVFGFQ-YSPIEAI 116

Query: 128 GLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVFNVGGA 187
           G YIPGG  PL ST LM   PA +AGC++ V CSP  +   IL AA L G  + + +GGA
Sbjct: 117 GAYIPGGRFPLISTALMTLIPARVAGCQRRVACSP-SVHPAILAAASLAGATEFWQIGGA 175

Query: 188 QAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGA 247
           QA+AA+A+G +++  V  + GPGN +V  AK+ +  R+    ID+ AGPSE+L++ADS A
Sbjct: 176 QAVAAMAYGYQTMLPVQMVVGPGNQYVNVAKQLLQSRIK---IDVAAGPSELLILADSNA 232

Query: 248 TPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAV--ERQLAELPRAETARQALNAS 305
             +++ +D+ +QAEH P +Q +L++      + + + +    +L  L + E         
Sbjct: 233 NQEWLIADMAAQAEHDPQAQSVLVSDDIAFLQSIGQQLTANDELNNLLKGEQI------- 285

Query: 306 RLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGT 365
            L+   D    +  SN+Y PEHL++   + R    S+   GS+F+G  S  + GDY +G 
Sbjct: 286 VLLQANDCEAMIRFSNRYAPEHLLL--ADERIASQSLKHYGSLFIGQNSAVAFGDYCAGP 343

Query: 366 NHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTL 425
           NH LPT G     S L +  F    + Q+++ +G   LA     LA AE+L  H+ ++ +
Sbjct: 344 NHTLPTMGSANRSSGLCVQSFMNIQSYQQINDQGRIQLAEIGRPLAEAEQLVWHERSMQV 403

Query: 426 R 426
           R
Sbjct: 404 R 404


>UniRef50_B1ZNB2 Histidinol dehydrogenase n=3 Tax=Verrucomicrobia RepID=B1ZNB2_OPITP
          Length = 431

 Score =  424 bits (1090), Expect = e-117,   Method: Composition-based stats.
 Identities = 152/433 (35%), Positives = 233/433 (53%), Gaps = 14/433 (3%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
             I+   S T +       R  +     IT +V  IL +V+ RGDEA+  Y+AKFD   +
Sbjct: 1   MRILHHASKTFDADVADFCRTTM-VPREITESVAAILADVRERGDEAVVYYAAKFDGAKL 59

Query: 64  T--ALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVT 121
               L+V   ++  A++RL    ++A+  A  +I  ++          +   G    +  
Sbjct: 60  RARDLRVKPSDLTVAAKRLPAAERRALVAARDSIMDYNRRGLPRGWTAKNPHGAMVGEKF 119

Query: 122 RPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSP----PPIADEILYAAQLCG 177
            P+  VGLY+PGG  PL STVLM  T A IA C +VV+ +P      IAD +L A  L G
Sbjct: 120 DPLRRVGLYVPGGQVPLVSTVLMTVTLAKIAQCPQVVVFTPCNAEGKIADGLLAALHLLG 179

Query: 178 VQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPS 237
           V +V+ VGG QAI A+AFGT ++P VDKIFGPGNA+  EA RQV   +    ++   GPS
Sbjct: 180 VDEVYRVGGVQAIGAMAFGTTTIPPVDKIFGPGNAYTCEAMRQVFGIV---GVNGLPGPS 236

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPD-SQVILLTPAADMARRVAEAVERQLAELPRAE 296
           E++VIAD  A  D+ A+DLL+QAEHG    +V L+  ++ +   +   +  QL  L R+E
Sbjct: 237 ELMVIADDTARADYAAADLLAQAEHGSGREKVYLVATSSRVITEIVNEMNGQLQTLTRSE 296

Query: 297 TARQALNASRL-IVTKDLAQCVEISNQYGPEHLIIQTRNA--RELVDSITSAGSVFLGDW 353
             ++ L    L I    + Q   ++N   PEHL +    A  ++L  ++T+AG++ +G+ 
Sbjct: 297 KTQRVLEQGFLAIEVGSMQQAAAVANYVAPEHLELLVSEAAVKQLTKAVTTAGAIMIGNE 356

Query: 354 SPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAA 413
           +P + GD+ +G +HVLPT       S + ++DF +R ++    ++     A  +   AA 
Sbjct: 357 TPTALGDFTAGPSHVLPTGRAGRFFSGMRVSDFLRRTSLVRYDRKSVRKGAPVVAAFAAM 416

Query: 414 ERLTAHKNAVTLR 426
           ERL AH  +V +R
Sbjct: 417 ERLDAHGRSVKIR 429


>UniRef50_C1A4M1 Histidinol dehydrogenase n=1 Tax=Gemmatimonas aurantiaca T-27
           RepID=C1A4M1_GEMAT
          Length = 816

 Score =  419 bits (1079), Expect = e-116,   Method: Composition-based stats.
 Identities = 154/430 (35%), Positives = 237/430 (55%), Gaps = 15/430 (3%)

Query: 8   DWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALK 67
            W+      +R L  R A +   +I    + ++D V+  GD AL + + +FD  T+  L+
Sbjct: 12  SWDRLDNATRRALEDR-ASTVDPTIRERTSAVIDAVRRTGDAALIDMARRFDGATLETLE 70

Query: 68  VSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASV 127
           V   E   A   L   L+Q++  A +NI T H A          +PG+   +   P+  V
Sbjct: 71  VPRAEWDRALAALDPALRQSLERAARNIATVHRAFLPTITRSTPEPGITVVRRPDPLGRV 130

Query: 128 GLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIAD----EILYAAQLCGVQDVFN 183
           G+Y PGG A   S++LM A PA +AG  ++++C+PP         +L AA L  V  VF 
Sbjct: 131 GIYAPGGRAAYPSSLLMGAVPARVAGVGEIIVCTPPGPDGRPADVVLAAAALANVDRVFA 190

Query: 184 VGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIA 243
           VGGA AIAA+A GT SVP+VD+I GPGNA+V EAK Q+   +   AID PAGPSE+LV+A
Sbjct: 191 VGGAGAIAAMALGTASVPRVDRIMGPGNAYVAEAKLQL---VSAVAIDAPAGPSELLVLA 247

Query: 244 DSGATPDFVASDLLSQAEHGPDSQVILLTPA----ADMARRVAEAVERQLAELPRAETAR 299
           D+ A  + +A ++L+QAEH PD+ V+ +       + +A RV  A++ QLA  PRA+  R
Sbjct: 248 DASADANTIAREMLAQAEHDPDAAVLAVIVDHSATSSLATRVETALQTQLASAPRADVMR 307

Query: 300 QALNA-SRLIVTKDLAQCVEISNQYGPEHLIIQTRNA--RELVDSITSAGSVFLGDWSPE 356
            AL A   ++    + + +  +N++  EHL++   +     ++ ++ +AG++F+G  S  
Sbjct: 308 AALGARGGVVHMTSMDEAITFANRWAAEHLLLLVDDTQRDRVLAALRNAGTIFVGASSSV 367

Query: 357 SAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERL 416
           + GDY +G NHVLPT G   + S L   DF +  T QE++    ++L++ +   A AE L
Sbjct: 368 AFGDYMTGANHVLPTAGAARSYSGLSTLDFVRWTTWQEVTPAAAASLSADVGRFADAEGL 427

Query: 417 TAHKNAVTLR 426
            AH       
Sbjct: 428 PAHAATARTW 437


>UniRef50_C9SQK1 Histidine biosynthesis trifunctional protein n=1 Tax=Verticillium
           albo-atrum VaMs.102 RepID=C9SQK1_VERA1
          Length = 699

 Score =  412 bits (1061), Expect = e-113,   Method: Composition-based stats.
 Identities = 160/434 (36%), Positives = 223/434 (51%), Gaps = 79/434 (18%)

Query: 7   IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTAL 66
            D +  +A +  ++L RP+  + E+I   V  I+D V++ GD+A+  Y+ KF+K T    
Sbjct: 338 YDASKVSAAEVTEVLKRPSQKSPEAILNIVKPIIDEVRSGGDKAVLSYTHKFEKATSLTS 397

Query: 67  KVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKL-PPVDVETQPGVRCQQVTRPVA 125
            V        + +LS E  +A+ ++ +NI  FH AQK   P+ VET PGV C +++RP+ 
Sbjct: 398 PVLRAPFPEEAMKLSKESIKAIDISFENIRKFHAAQKEDKPLHVETMPGVVCSRMSRPIE 457

Query: 126 SVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIA----DEILYAAQLCGVQDV 181
            VGLYIPGG+A L ST LML  PA +AGCKK+V  SPP        EI+Y A   G + +
Sbjct: 458 RVGLYIPGGTAVLPSTALMLGVPAMVAGCKKIVFASPPRADGSLTPEIVYVAHKVGAESI 517

Query: 182 FNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLD-GAAIDMPAGPSEVL 240
              GGAQA+AALA+GTESVPKVDKI GPGN FVT AK  VS   + G +IDMPAGPSEV 
Sbjct: 518 VLAGGAQAVAALAYGTESVPKVDKILGPGNQFVTAAKMFVSNDTNAGVSIDMPAGPSEVR 577

Query: 241 VIADS-GATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETAR 299
            I ++   + D+    L+ Q ++ P                               E A+
Sbjct: 578 DIDEAMRISNDYAPEHLILQLKNAP-------------------------------EVAQ 606

Query: 300 QALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAG 359
             +NA  +                                         F+G+W+PES G
Sbjct: 607 MVMNAGSI-----------------------------------------FIGEWTPESVG 625

Query: 360 DYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAH 419
           DY++G NH LPTYG+    S + L  F K +T   L+ EG   + S +  LA  E L AH
Sbjct: 626 DYSAGVNHSLPTYGFAKQYSGVNLGSFVKHITSSNLTAEGLRNVGSAVMQLAKVEELEAH 685

Query: 420 KNAVTLRVNALKEQ 433
           + AV +R+N L ++
Sbjct: 686 RRAVEIRLNYLDKK 699


>UniRef50_B5YLM0 Histidinol dehydrogenase n=1 Tax=Thalassiosira pseudonana CCMP1335
           RepID=B5YLM0_THAPS
          Length = 441

 Score =  404 bits (1040), Expect = e-111,   Method: Composition-based stats.
 Identities = 140/397 (35%), Positives = 204/397 (51%), Gaps = 22/397 (5%)

Query: 49  EALREYSAKFDKTTV--TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPP 106
           +AL   + +        ++  VS+ +   A + LSDE ++++      ++ F  AQ+   
Sbjct: 48  KALISIARRLSDILPASSSYTVSSAQCKEAFDSLSDEDRRSLLNIHARVKLFADAQRGSV 107

Query: 107 VDVE-TQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPI 165
           VDVE   PG +      P  + G Y PGG  PL S+VLM    A  AGC  VVL SP P 
Sbjct: 108 VDVEVDIPGGKAGHTVSPCRAAGCYAPGGRYPLPSSVLMTVVTARSAGCPYVVLASPRP- 166

Query: 166 ADEILYAAQLCGVQDVFNVGGAQAIAALAFGTE------------SVPKVDKIFGPGNAF 213
           A   L AA + G   V  VGGAQAI  +A+G +            ++P  D I GPGN +
Sbjct: 167 APITLAAAHVAGADVVLCVGGAQAIGCMAYGVDEYDGEDGGTKVDAIPACDVIVGPGNKW 226

Query: 214 VTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTP 273
           VT AK  V+       IDM AGPSEVLVI D  A  + VA+DL++QAEH   ++ IL++ 
Sbjct: 227 VTAAKSIVNGH---CGIDMLAGPSEVLVICDHTANAEIVAADLIAQAEHDVVARAILVSD 283

Query: 274 AADMARRVAEAVERQLAELP--RAETARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQ 331
              +  +V + VE+Q+  LP     TA++AL  S  I+ KD+ +C+ +S++  PEHL IQ
Sbjct: 284 DKTVIDKVDQEVEKQVECLPEPNRSTAKEALKQSFSILCKDIDECIAMSDKLAPEHLEIQ 343

Query: 332 TRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMT 391
           T N++ +    ++ G +F+G  + E  GDY +G NH LPT G       L + +F +  T
Sbjct: 344 TLNSQSVGMKCSNYGGLFIGTHAAEVLGDYGAGPNHTLPTGGTGRYTGGLSVFNFLRIRT 403

Query: 392 VQELSKEG-FSALASTIETLAAAERLTAHKNAVTLRV 427
              + +EG    +      +A  E L  H  A   R 
Sbjct: 404 WMRIDEEGKSQEMVEDSVRMARLEGLEGHARAAEKRR 440


>UniRef50_UPI0001C3165E histidinol dehydrogenase n=1 Tax=Conexibacter woesei DSM 14684
           RepID=UPI0001C3165E
          Length = 426

 Score =  388 bits (997), Expect = e-106,   Method: Composition-based stats.
 Identities = 145/414 (35%), Positives = 206/414 (49%), Gaps = 18/414 (4%)

Query: 22  MRPAISASESITRTVNDILDNVKARGDEALREYSAKFD--KTTVTALKVSAEEIAAASER 79
           +R  + A+ SI   V  I+ +V+ RGD A+ E +   D       AL+VS  E+ AA + 
Sbjct: 21  LRRLVPAAASIADPVAAIVADVRDRGDAAVLELTRAHDTGGAEPKALRVSQSELDAALDS 80

Query: 80  LSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLF 139
           L  +++  + VA +N+            +V    G   +    PV    +Y+PGG AP  
Sbjct: 81  LDADVRAGLEVAAQNVGVVAAIGLDDEREVTLGHGQTVRLREVPVRRAAVYVPGGRAPYP 140

Query: 140 STVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQDVFNVGGAQAIAALAF 195
           STVLM    A  AG ++VVLCSPP     +   IL AA L G  +V+ +GGAQAI ALA 
Sbjct: 141 STVLMGVVTAVTAGVEEVVLCSPPGPDGDLNPAILAAAALAGATEVYRMGGAQAIGALAH 200

Query: 196 GTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASD 255
           GT +V  VD I GPGN +V EAKRQVS       ID  AGPS+++V+ D GA     A D
Sbjct: 201 GTATVAPVDLIVGPGNLWVQEAKRQVSA-AGLVGIDGFAGPSDLMVVLDRGADVRLAALD 259

Query: 256 LLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQ 315
           L +QAEHG DS V+ ++P           +   L+ +P             L+ T  L  
Sbjct: 260 LRAQAEHGSDSLVLAVSPDGAALDA----LSEGLSVVPEPGV-------GALVETASLED 308

Query: 316 CVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYT 375
            + ++N + PEHL +    A  L   + +AG +F+G     + GDY +G+NH LPT G  
Sbjct: 309 ALALANAFAPEHLELIGAGAEALAPEVRNAGCLFVGPGGATAFGDYVAGSNHTLPTDGAA 368

Query: 376 ATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNA 429
              S L    F++RMT   +  E  + LA     +A AE    H  ++  R+  
Sbjct: 369 RFASGLSARHFRRRMTEVRIPLEAATTLAPAGAAIARAEGFELHAQSMEARMRE 422


>UniRef50_C6UN35 Histidinal/histidinol dehydrogenase n=1 Tax=Candidatus Hodgkinia
           cicadicola Dsem RepID=C6UN35_HODCD
          Length = 428

 Score =  380 bits (977), Expect = e-104,   Method: Composition-based stats.
 Identities = 138/426 (32%), Positives = 203/426 (47%), Gaps = 11/426 (2%)

Query: 7   IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTAL 66
           +  +S    +  + ++      S  +      I   V A  D+AL  Y+ + D      L
Sbjct: 5   LRSDSPGFGEFVKGVIASRARVSARVKAVAEKISQTVSAYADKALMAYNLRLDGCASRLL 64

Query: 67  KVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVAS 126
           + +  +I    E +  +   ++ +A+  +   H+ Q      V    G +      PV+S
Sbjct: 65  RFAP-DID--LETVDVKALFSLKLALDRVAALHSLQLPSSCCVRDALGAKLGFRWTPVSS 121

Query: 127 VGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPI---ADEILYAAQLCGVQDVFN 183
           VG+Y+PGG+A   S+V+M   PA IAG   + L +P          +  A+LCGV  V+ 
Sbjct: 122 VGVYVPGGTASYLSSVIMCCVPARIAGVGHISLATPYSKLANKPLFMACAKLCGVACVYP 181

Query: 184 VGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIA 243
            GGA A+AAL+ GT +V KVDKI GPGNAFV  AK     R+    +D  AGPSE +++A
Sbjct: 182 FGGAHAVAALSVGTRAVRKVDKIVGPGNAFVAAAKALAQGRV---GVDCLAGPSEAVIVA 238

Query: 244 DSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALN 303
           D  A    +A D L Q EH  D+   ++  +A++A RV   V   +    R  TA ++ +
Sbjct: 239 DGVADAWTLAVDSLCQLEHASDALTAVVVSSAELASRVRANVALLVRSARRRRTAERSWS 298

Query: 304 ASRL-IVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYA 362
           A  + +V   +A      N    EH+        +L+  +TSAG+VFLG  SP   GDY 
Sbjct: 299 AGGVSVVCCCVADAAATVNALASEHVQACVLKPAKLLTKLTSAGAVFLGGGSPIVVGDYV 358

Query: 363 SGTNHVLPTYGYTATCSSLGLADFQKRMTVQEL-SKEGFSALASTIETLAAAERLTAHKN 421
            GTNH LPT       S L + DF KR  V  L +     ALA      A+AE L+ H  
Sbjct: 359 GGTNHTLPTASGAKFASGLSVLDFMKRTYVTWLPTARPMLALAPACAACASAEGLSCHAL 418

Query: 422 AVTLRV 427
           A   R+
Sbjct: 419 ASASRL 424


>UniRef50_A8M914 Histidinol dehydrogenase n=1 Tax=Caldivirga maquilingensis IC-167
           RepID=A8M914_CALMQ
          Length = 399

 Score =  378 bits (971), Expect = e-103,   Method: Composition-based stats.
 Identities = 131/414 (31%), Positives = 209/414 (50%), Gaps = 31/414 (7%)

Query: 21  LMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERL 80
           L+R A    + +   V  I+++VK  GDEAL   +++ D   ++++++S  E+ A +  +
Sbjct: 11  LLRKATDMDQYV-DRVRGIINDVKEHGDEALLRLTSELDGVKLSSIELSQSELRALASGI 69

Query: 81  SDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFS 140
              +++A+   + ++E+F+T  K    +   + G+R      P++ VGLY+P G    FS
Sbjct: 70  EPRVREALDEVMASVESFNTGVKPRDFEDYHR-GLRRGVKWVPLSRVGLYVPKG---YFS 125

Query: 141 TVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQDVFNVGGAQAIAALAFG 196
           T++M    A +AG ++++  +PP     I  EI Y A       VF VGGAQA+AALAFG
Sbjct: 126 TLVMTGVLAKVAGVEEIIAVTPPRRDGLIDPEIAYVALRLNA-RVFRVGGAQAVAALAFG 184

Query: 197 TESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDL 256
           TESVP+VDKI GPGNA+V  AK  VS  +    ID   GP+E++  AD G  P  VA DL
Sbjct: 185 TESVPRVDKIIGPGNAYVQAAKLLVSSHV---GIDGVEGPTELVTCADPGIKPITVALDL 241

Query: 257 LSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQC 316
            +Q EH   +  +++T +      + + + + L   P               +  + ++C
Sbjct: 242 AAQLEHA-GAVGVVVTWSEGYLTAIEDELSK-LTNAP-----------YFSTLVNEPSEC 288

Query: 317 VEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTA 376
           V + N+  PEH  I     +  ++ I +AG+V +   +P +  DYA+G +HVLPT G   
Sbjct: 289 VNVINEVAPEHASIW--GVKIPIEGIRNAGAVSI--MAPSALVDYAAGPSHVLPTGGSAR 344

Query: 377 TCSSLGLADFQKRMTVQE-LSKEGFSALASTIETLAAAERLTAHKNAVTLRVNA 429
               L   DF K +   E  S +    L      L   E    H  A+T  +N 
Sbjct: 345 WRGVLTPMDFMKPIAYVEPTSGDEARRLGELGAVLGLREGFRRHSEALTNWINE 398


>UniRef50_B7FPZ7 Histidinol dehydrogenase (Fragment) n=3 Tax=Eukaryota
           RepID=B7FPZ7_PHATR
          Length = 347

 Score =  377 bits (968), Expect = e-103,   Method: Composition-based stats.
 Identities = 134/338 (39%), Positives = 182/338 (53%), Gaps = 10/338 (2%)

Query: 95  IETFHTAQKLPPVDVE-TQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAG 153
           +  F T Q+   VD E   PG +  Q  RP  + G Y PGG  PL S+V+M A  A  AG
Sbjct: 1   VLAFATMQRSSVVDKEMDIPGGKAGQTVRPCGAAGCYAPGGRYPLPSSVIMTAVTARAAG 60

Query: 154 CKKVVLCSPPPIADEILYAAQLCGVQDVFNVGGAQAIAALAFGT--ESVPKVDKIFGPGN 211
           C+ VVL SP   A   L AA L G      VGGAQAIA++A+G     VP+ D I GPGN
Sbjct: 61  CETVVLSSP-KPAPITLAAAYLSGADHFLCVGGAQAIASMAYGIVDSDVPRCDVICGPGN 119

Query: 212 AFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILL 271
            +VT AK  V+       IDM AGPSEVLVI D  A P+ VA+DL++QAEH   ++ ILL
Sbjct: 120 KWVTAAKSIVNGH---CGIDMLAGPSEVLVICDDTANPEIVAADLIAQAEHDVVARAILL 176

Query: 272 TPAADMARRVAEAVERQLAELP--RAETARQALNASRLIVTKDLAQCVEISNQYGPEHLI 329
           + +  +  +V E V +Q+  LP     TA +AL  S  +  + L QC+ IS+   PEHL 
Sbjct: 177 STSDAIIEQVDENVSKQIEALPEPNRSTALEALKQSFAVKCESLEQCIAISDDIAPEHLE 236

Query: 330 IQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKR 389
           IQTR+A ++ ++  + G +F+G+ + E  GDY +G NH LPT G       L + +F + 
Sbjct: 237 IQTRDAMKVGEACNNYGGLFIGEHAAEVLGDYGAGPNHTLPTGGTGRYTGGLSVFNFLRV 296

Query: 390 MTVQELS-KEGFSALASTIETLAAAERLTAHKNAVTLR 426
            T   +        + +    +A  E L  H  A   R
Sbjct: 297 RTWMRVDNAAASQTMVNDSIIMARLEGLEGHARAAETR 334


>UniRef50_A8A9G5 Histidinol dehydrogenase n=1 Tax=Ignicoccus hospitalis KIN4/I
           RepID=A8A9G5_IGNH4
          Length = 404

 Score =  341 bits (876), Expect = 3e-92,   Method: Composition-based stats.
 Identities = 126/410 (30%), Positives = 195/410 (47%), Gaps = 34/410 (8%)

Query: 23  RPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSD 82
           R ++   E + + V  ++  VKARG EA+++Y+  FD      + +S E+ A+ S+   +
Sbjct: 26  RGSLDLWEYVEK-VMPVVKEVKARGLEAVKKYNKAFDNYE-GCVSLSQEDFASYSK---E 80

Query: 83  ELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTV 142
            L       ++ +  FH           +  GVR   + RPV  +G Y+PGG  P  ST 
Sbjct: 81  SLVSLFEEVLEQLSAFHKQTAPKD-SAFSSKGVRAVTLWRPVERLGAYVPGGLYPYPSTA 139

Query: 143 LMLATPASIAGCKKVVLCSPPPIA-DEILYAAQLC-GVQDVFNVGGAQAIAALAFGTESV 200
           LM A  A   G K+V + +PP  A  E++ +A L   V  V   GGA  ++ALA+    V
Sbjct: 140 LMTAGVAKALGVKEVTVATPPKFATSEVMASAFLASKVDSVLAAGGAHGVSALAY----V 195

Query: 201 PKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQA 260
               K+ GPG  +V  AK  VS  +    IDM AGP+E+ VIADS A P+ VA D+L+QA
Sbjct: 196 AGAHKVVGPGGPYVQAAKLLVSVDVP---IDMIAGPTELAVIADSSADPEEVAYDMLAQA 252

Query: 261 EHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQCVEIS 320
           EHGP S  +L++    +   V + V+             +        V +DL +   + 
Sbjct: 253 EHGPTSFALLVSTDEGLVLEVEKRVK-----------GEEVEGGLYATVVRDLEEAKRLV 301

Query: 321 NQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSS 380
           ++  PEH+ +        V     AG+      +P    DY++G NHVLPT G+      
Sbjct: 302 SELAPEHVSVYAETYEPPV-----AGAASF--KAPSPFLDYSAGPNHVLPTSGWAKARGP 354

Query: 381 LGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNAL 430
           LG  DF +  T+ E+  E  + L      LA  E +  H  A+  +++ +
Sbjct: 355 LGPVDFMRWTTLVEVFPEA-ADLLKLAAELARLEGMKYHAKAIEYKLSKI 403


>UniRef50_B9NIZ3 Histidinol dehydrogenase n=1 Tax=Populus trichocarpa
           RepID=B9NIZ3_POPTR
          Length = 394

 Score =  327 bits (838), Expect = 8e-88,   Method: Composition-based stats.
 Identities = 112/275 (40%), Positives = 157/275 (57%), Gaps = 12/275 (4%)

Query: 7   IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVT-- 64
           +       E      +  +     +I + V DIL +V+ RGD A+ EY+A+FD   V   
Sbjct: 114 LSTADANFEHDFAQRLHWSADTDAAIEQRVADILADVQKRGDAAVLEYTARFDGLQVEGM 173

Query: 65  -ALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKL---PPVDVETQPGVRCQQV 120
            AL+++  E+ AA + L DE + A+  A + + T+H AQK             G    Q 
Sbjct: 174 AALELTQAELKAAFDSLGDEQRDALTAAAQRVRTYHEAQKRASGESWSYRDADGTLLGQK 233

Query: 121 TRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCG 177
             P+  VG+Y+PGG A   S+VLM A PA +AG +++++  P P       +L AA + G
Sbjct: 234 VTPLDRVGIYVPGGKAAYPSSVLMNAIPAHVAGVQEIIMVVPTPRGEKNALVLAAAYVAG 293

Query: 178 VQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPS 237
           V   F +GGAQA+AALA+GT ++PKVDKI GPGNA+V  AK++V   +    IDM AGPS
Sbjct: 294 VTRGFTIGGAQAVAALAYGTATIPKVDKITGPGNAYVASAKKRVFGTV---GIDMIAGPS 350

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPDSQVILLT 272
           E+LV+AD    PD+VA DL SQAEH   +Q ILL 
Sbjct: 351 EILVLADGSTPPDWVAMDLFSQAEHDELAQSILLC 385


>UniRef50_P72946 Putative histidinol dehydrogenase 2 n=1 Tax=Synechocystis sp. PCC
           6803 RepID=HISX2_SYNY3
          Length = 409

 Score =  319 bits (818), Expect = 1e-85,   Method: Composition-based stats.
 Identities = 100/394 (25%), Positives = 167/394 (42%), Gaps = 20/394 (5%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              +I  +    ++ R+L  RP  S    + + V             A  E+ A  D   
Sbjct: 1   MLRLITQSGDIVQELRRLHHRPVPSPWPVMAQVV-------------AAMEHWAAMD--Q 45

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
               +VS  E+ AA +R+S E    +  A   +E  +  Q         + G    Q   
Sbjct: 46  DAPPRVSGAELDAAYQRISQEKLSVIRQACAALEQVYRPQLPKTQVSFPEDGTVRGQRFY 105

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVF 182
           PV   G Y+          +L     A   G  + VL +   I+  IL AAQ  G+++++
Sbjct: 106 PVRRAGFYLEAKRGDALGNLLRQGMLAKTVGVAERVLVTE-TISSTILVAAQEMGIEEIY 164

Query: 183 NVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVI 242
              G  AIA L +G +++  V+ I G G   V  AK+ VS  +    ID     + ++V+
Sbjct: 165 LAAGVPAIAMLTWGAKNIAPVESITGAGCPRVMAAKQLVSGVV---TIDQTLARTNLMVL 221

Query: 243 ADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL 302
           AD  A   ++A DLL+ AE  P++  +LLT   ++   V ++V R   E   +    +AL
Sbjct: 222 ADGEANGQWLALDLLAHAEQYPNASAVLLTDRLELGEEVIQSVNRYCREQEHSVHTEKAL 281

Query: 303 NASRLI-VTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDY 361
               L+ + +DL  C    N++ P  L++   +   +V+ +  A  +++G  SP   G Y
Sbjct: 282 AHYGLVAIVEDLEACGSWINEFCPHILLLAMEDPWTMVEKVQRAREIYIGHRSPSILGHY 341

Query: 362 ASGTNHVLPTYGYTATCSSLGLADFQKRMTVQEL 395
            SG N +    G  AT S L    F +   + + 
Sbjct: 342 LSGANRLQTQDGAMATASELAFHCFLRSSQLLDY 375


>UniRef50_Q8ZY17 Histidinol dehydrogenase n=5 Tax=Thermoproteaceae RepID=HISX_PYRAE
          Length = 368

 Score =  298 bits (764), Expect = 3e-79,   Method: Composition-based stats.
 Identities = 109/400 (27%), Positives = 180/400 (45%), Gaps = 34/400 (8%)

Query: 26  ISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELK 85
                 +  +V  I+D+V++ G +A  EYS + D        V+  +          E+ 
Sbjct: 2   RGFPREVLESVWKIVDDVQSGGLKAALEYSKRLDGVAPEPHLVTPRQ------GGDPEVV 55

Query: 86  QAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLML 145
            A   A K++E  ++    PP  V+   G+  Q + +PV    LY+P   A   ST++ML
Sbjct: 56  SAALAAAKSLEALYSR-ISPPAAVDFYGGILRQILWKPVRRAALYVP---ARYISTLVML 111

Query: 146 ATPASIAGCKKVVLCSPP-PIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVD 204
           A PA +AG ++V + +PP  +++E+L  A+  GV+ V  +GG   +A   F       VD
Sbjct: 112 AVPARLAGVEEVYVVTPPRGVSEELLAVAKELGVKAVLALGGPHGLAYAVFHM----GVD 167

Query: 205 KIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGP 264
            + GPG  +V  AK  +SQ +    ID   GP+E+++ A  G  P+      L+Q EHGP
Sbjct: 168 VVAGPGGLYVQAAKYILSQYV---GIDGIEGPTELVIYA-EGVPPEVAVRGALAQLEHGP 223

Query: 265 DSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQCVEISNQYG 324
            S   LL+P  ++ ++  E   R+            ++   ++     + + V   ++  
Sbjct: 224 TSFAYLLSPDGELLKKAEELYVRERT---------SSMGPLKVKKVGGIDEAVSFIDEIA 274

Query: 325 PEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLA 384
           PEHL +  R  RE+   + + G+V +    P    DY +G +HVLPT G       +   
Sbjct: 275 PEHLEVWGR--REVAYRVRNVGAVSVNM--PSPYLDYVAGISHVLPTGGTARWRGVITPL 330

Query: 385 DFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVT 424
            F K + + E   E    L      LA  E    H  A+ 
Sbjct: 331 AFMKPIGIAEAVGE--LTLREAARKLAEYEGFKYHGEALR 368


>UniRef50_B8NVQ6 Histidinol dehydrogenase, putative n=1 Tax=Aspergillus flavus
           NRRL3357 RepID=B8NVQ6_ASPFN
          Length = 224

 Score =  224 bits (572), Expect = 5e-57,   Method: Composition-based stats.
 Identities = 78/247 (31%), Positives = 113/247 (45%), Gaps = 39/247 (15%)

Query: 187 AQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSG 246
             A+AA+A GTE++ KVD + G GN FV E KRQ+   +    ID+ AGP+EVLV+AD  
Sbjct: 11  VPAVAAIAVGTETIRKVDFLAGTGNRFVAEGKRQLFGEV---GIDLFAGPTEVLVLADET 67

Query: 247 ATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLA--ELPRAETARQALNA 304
           A P  VA DL+SQA HGPD+  +L+T    + R   E V + L+  +L   + A+ + +A
Sbjct: 68  ADPFTVAMDLISQAGHGPDTPAVLITTCPKVGRETIEIVNKLLSATDLSTPDVAKVSWDA 127

Query: 305 -SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYAS 363
              +I+   L +  E+ + Y  E + +                                 
Sbjct: 128 FGEVIIVDTLEELWELGDHYASEQVQVI-------------------------------- 155

Query: 364 GTNHVLPTYGYTATCSSLGLADFQKRMTVQELS-KEGFSALASTIETLAAAERLTAHKNA 422
           GTNH+LPT         L +  + K  T QE++  E    L       A  ER  A   +
Sbjct: 156 GTNHILPTRTTARYTGGLWVGKYLKTCTYQEVTLPESSGKLGRLCGRAARPERFEAPARS 215

Query: 423 VTLRVNA 429
             LR N 
Sbjct: 216 GDLRANR 222


>UniRef50_UPI0001909A69 histidinol dehydrogenase n=1 Tax=Rhizobium etli IE4771
           RepID=UPI0001909A69
          Length = 287

 Score =  211 bits (539), Expect = 3e-53,   Method: Composition-based stats.
 Identities = 65/178 (36%), Positives = 94/178 (52%), Gaps = 6/178 (3%)

Query: 20  LLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA---LKVSAEEIAAA 76
           L +      SE +      I+D+VKARGD AL    A   +   +    ++V+ EEI AA
Sbjct: 31  LFLTTKREVSEDVNAVARAIIDDVKARGDVALCRIFADIRRHRFSPPVPMRVTPEEIDAA 90

Query: 77  SERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSA 136
            E +  E+  A+ +A   IE+ H  Q       E   GVR       + +VGLY+PGG+A
Sbjct: 91  VEAVPSEVLGALKLAALRIESHHRRQLPKDDIYEDDLGVRLGSRWTAIEAVGLYVPGGTA 150

Query: 137 PLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCGVQDVFNVGGAQAIA 191
              S+VLM A PA +AG  ++V+  P     +   +L AA+L GV +++ VGGAQAIA
Sbjct: 151 SYPSSVLMNAVPAKVAGVDRIVIAVPATGGAVNPAVLAAARLAGVTEIYRVGGAQAIA 208


>UniRef50_C5GHZ5 Histidinol dehydrogenase n=2 Tax=Ajellomyces dermatitidis
           RepID=C5GHZ5_AJEDR
          Length = 281

 Score =  209 bits (532), Expect = 2e-52,   Method: Composition-based stats.
 Identities = 72/270 (26%), Positives = 116/270 (42%), Gaps = 63/270 (23%)

Query: 65  ALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPV 124
           + K+S  +I AA  ++S++  + +  A  N                         +   V
Sbjct: 2   SFKLSEGDIEAAVVKVSEQTIKDIKEAQAN-----------------------GYIW--V 36

Query: 125 ASVGLYIPGGSAPLFSTVLMLATP---ASIAGCKKVVLCSPP---PIADEILYAAQLCGV 178
             + L +  G   L S+          + +AG   V +C+PP    I +       L G 
Sbjct: 37  RRIFLLVQLGRRFLPSSFHTQEVQFCNSKVAGVNHVTMCTPPINGKIPNATTATTHLVGA 96

Query: 179 QDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSE 238
            ++F +GGAQAIA +A GTES+ KVD I   G                   +D+ AGP+E
Sbjct: 97  NEIFILGGAQAIAGMAVGTESIRKVDSIAEIG-------------------VDLFAGPTE 137

Query: 239 VLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETA 298
           V             A+ LLSQAEHGPDS  +L+T + D A++V   ++R L  L  A  A
Sbjct: 138 V------------PATHLLSQAEHGPDSPAVLITTSEDSAKQVMTLIDRFLETLSTAAIA 185

Query: 299 RQALNASR-LIVTKDLAQCVEISNQYGPEH 327
             A  + R +++   + +   + ++Y  +H
Sbjct: 186 STAWRSFREVVIVDSIDEAYALGDEYAFDH 215


>UniRef50_C7H2J0 Histidinol dehydrogenase n=1 Tax=Faecalibacterium prausnitzii
           A2-165 RepID=C7H2J0_9FIRM
          Length = 162

 Score =  205 bits (523), Expect = 2e-51,   Method: Composition-based stats.
 Identities = 51/164 (31%), Positives = 84/164 (51%), Gaps = 4/164 (2%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              + +++    E+     +   I A +++   V+ I+  V+ARGDEAL+EY+ KFD   
Sbjct: 1   MIKLYNFDELRPEEI----LNRDIRAEKNVEDVVDGIIAEVRARGDEALKEYALKFDGAK 56

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
           +  L+V+  EI  A   +     + +  A  NIE+FH  Q      +  +PG+   Q   
Sbjct: 57  IDDLQVTQAEIDEAFANMDPYFLETLREAAANIESFHRQQVHKNFVINEKPGIVLGQKYT 116

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIA 166
           P+   G+Y+PGG+A   STVLM   PA +AG  ++V+ +P    
Sbjct: 117 PIEKAGVYVPGGTAAYPSTVLMDVIPAKVAGVSEIVMTTPAGKD 160


>UniRef50_A3J633 Histidinol dehydrogenase (Fragment) n=1 Tax=Flavobacteria bacterium
           BAL38 RepID=A3J633_9FLAO
          Length = 136

 Score =  159 bits (403), Expect = 2e-37,   Method: Composition-based stats.
 Identities = 57/140 (40%), Positives = 83/140 (59%), Gaps = 4/140 (2%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              I +      E   ++  RP  + S  +  TV  I   V+ +G++A+ +Y++ FD  T
Sbjct: 1   MKKIYN---PQPETWLEICKRPTQTFS-DVEETVKQIFKKVQQKGNKAIAKYTSFFDGVT 56

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
           +  ++V+ EEI  A + ++ ELK+A+ +A  NIE FH AQK   + VET  GV C Q  R
Sbjct: 57  LENIQVTPEEIELAKKEVATELKKAIQLAKSNIEQFHAAQKTDKIVVETTIGVTCWQEKR 116

Query: 123 PVASVGLYIPGGSAPLFSTV 142
           P+  VGLYIPGG+APLFSTV
Sbjct: 117 PIQKVGLYIPGGTAPLFSTV 136


>UniRef50_B4CYY3 NAD+ oxidoreductase n=1 Tax=Chthoniobacter flavus Ellin428
           RepID=B4CYY3_9BACT
          Length = 162

 Score =  133 bits (336), Expect = 1e-29,   Method: Composition-based stats.
 Identities = 40/147 (27%), Positives = 68/147 (46%), Gaps = 9/147 (6%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
              +  NS   +     L R A +    + +TV D+L+ ++  GD AL E++ +F    +
Sbjct: 1   MRTLRHNSPGFKSSLNSLKRSAEA-HPQVRKTVQDVLEAIRTEGDSALLEFTERFGGPRL 59

Query: 64  --TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVT 121
               L+V+ +       ++  E K+A+A A  N+  F          ++   G    +  
Sbjct: 60  TAKQLRVTGK------PKVDAETKEAVATAHANVLAFARKSLRENWTMKNAQGGLVGERF 113

Query: 122 RPVASVGLYIPGGSAPLFSTVLMLATP 148
            P   VG+Y+PGG+APL ST +M  TP
Sbjct: 114 DPFKRVGIYVPGGTAPLVSTAVMTVTP 140


>UniRef50_UPI0001696B01 histidinol dehydrogenase n=2 Tax=Listeria monocytogenes
           RepID=UPI0001696B01
          Length = 123

 Score =  120 bits (302), Expect = 1e-25,   Method: Composition-based stats.
 Identities = 38/114 (33%), Positives = 61/114 (53%)

Query: 15  EQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIA 74
           E   +L +    + S  +   V  I++ VK  GD+AL ++++KFD   +T L+V A +I 
Sbjct: 10  ELLNELKIETDTNTSIQVETEVKTIIEKVKTAGDQALFDFTSKFDGVGLTELRVPAADIQ 69

Query: 75  AASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVG 128
           AAS ++      A+  A  NIE+FH+ QK        + GV   Q+ RP+ +VG
Sbjct: 70  AASAKIEPAFLDALQQAKVNIESFHSKQKQHAFLDSEKDGVIRGQLIRPLETVG 123


>UniRef50_D1ND55 Histidinol dehydrogenase (Fragment) n=1 Tax=Haemophilus influenzae
           HK1212 RepID=D1ND55_HAEIN
          Length = 104

 Score =  111 bits (278), Expect = 6e-23,   Method: Composition-based stats.
 Identities = 43/105 (40%), Positives = 61/105 (58%), Gaps = 1/105 (0%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
             TII WN  +  ++R+++MRP     ++I + VN I +NV   GD AL E   KFD   
Sbjct: 1   MQTII-WNHLSETEKRKVIMRPVQQNGKNIQQAVNAIRENVAYNGDRALFELCEKFDGVK 59

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPV 107
           +  L VS +EI AAS R+S +L+ A+  A  NIE FH AQ+   +
Sbjct: 60  LDKLIVSVDEIQAASSRISVKLRNAIEQAKTNIEAFHKAQQNQEI 104


>UniRef50_D1KBK9 Histidinol dehydrogenase n=1 Tax=uncultured SUP05 cluster bacterium
           RepID=D1KBK9_9GAMM
          Length = 146

 Score = 95.9 bits (238), Expect = 3e-18,   Method: Composition-based stats.
 Identities = 27/122 (22%), Positives = 52/122 (42%), Gaps = 4/122 (3%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
               +       +++   L+     +S  I +TV+DI+ N++  GD+AL +Y+ KFD   
Sbjct: 1   MIARLSTQQADFQEKLSKLLAWESVSSTDIAQTVDDIIANIRQNGDQALIDYTNKFDGMD 60

Query: 63  VTA---LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQP-GVRCQ 118
           V+    L V    +  A + L+++ K A+  A   +  +    K   +   T+  G    
Sbjct: 61  VSDISALTVDQSALKKAFDSLAEKEKTALQSAADRVRDYPPKNKSKTLGTYTEDNGTLLG 120

Query: 119 QV 120
             
Sbjct: 121 SK 122


>UniRef50_C7ZHH7 Putative uncharacterized protein n=1 Tax=Nectria haematococca mpVI
           77-13-4 RepID=C7ZHH7_NECH7
          Length = 337

 Score = 81.3 bits (200), Expect = 7e-14,   Method: Composition-based stats.
 Identities = 19/70 (27%), Positives = 26/70 (37%), Gaps = 1/70 (1%)

Query: 362 ASGTNHVLPTYGYTATCSSLGLADFQKRMTVQE-LSKEGFSALASTIETLAAAERLTAHK 420
             G+NHVLPT         L +  F K  T QE + +     +       + AE    H 
Sbjct: 54  CIGSNHVLPTRKVGNYTGGLWVGKFLKTQTYQEIVDERASGEMGRLCGRCSRAENFEVHA 113

Query: 421 NAVTLRVNAL 430
            +  LRV   
Sbjct: 114 RSGDLRVKKY 123


>UniRef50_UPI00016988E7 histidinol dehydrogenase n=1 Tax=Endoriftia persephone
          'Hot96_1+Hot96_2' RepID=UPI00016988E7
          Length = 102

 Score = 66.3 bits (161), Expect = 2e-09,   Method: Composition-based stats.
 Identities = 18/82 (21%), Positives = 39/82 (47%), Gaps = 3/82 (3%)

Query: 1  MSFNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDK 60
          MS    +  +    + +   L+     +  ++  TVN+I+  +++RGD AL E++++FD 
Sbjct: 1  MSEIRQLSSSDADFQSRLDALLAWESVSDRAVNDTVNNIIAEIRSRGDAALVEFTSRFDG 60

Query: 61 TTVTA---LKVSAEEIAAASER 79
              +   L++    +  A E 
Sbjct: 61 WQAASAADLELPLSRLEQAWEH 82


>UniRef50_C0S8B7 Histidinol dehydrogenase n=1 Tax=Paracoccidioides brasiliensis Pb03
           RepID=C0S8B7_PARBP
          Length = 227

 Score = 62.8 bits (152), Expect = 2e-08,   Method: Composition-based stats.
 Identities = 27/103 (26%), Positives = 41/103 (39%), Gaps = 32/103 (31%)

Query: 239 VLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETA 298
           VL++A + A    +A+DLLSQAEH PDS  ++ T A D  +            L      
Sbjct: 128 VLIVAGNKADRFTIATDLLSQAEHSPDSPAVIFTTAEDAGK------------LETRY-- 173

Query: 299 RQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDS 341
                               ++++Y  EH+ I T+  RE    
Sbjct: 174 ------------------FRLADEYAFEHVQILTQPPREAGAR 198



 Score = 44.3 bits (104), Expect = 0.009,   Method: Composition-based stats.
 Identities = 13/43 (30%), Positives = 25/43 (58%), Gaps = 1/43 (2%)

Query: 37 NDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASER 79
            +++++++ GD A+R +S KFD    T  K S ++I A   +
Sbjct: 34 KRVIEDIRSNGDSAVR-HSTKFDHWEPTPFKPSDDDIQAVIAK 75


>UniRef50_D2MHU6 Putative uncharacterized protein (Fragment) n=1 Tax=Candidatus
          Poribacteria sp. WGA-A3 RepID=D2MHU6_9BACT
          Length = 74

 Score = 57.8 bits (139), Expect = 7e-07,   Method: Composition-based stats.
 Identities = 19/72 (26%), Positives = 29/72 (40%), Gaps = 2/72 (2%)

Query: 3  FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
             +I     T  +    +   A      I   V  IL NV+  GD A+  Y  KFD  T
Sbjct: 1  MMNVISSKDKTYPEALAEVCNRAACQHAKIEGRVKRILKNVERNGDAAVSRYVKKFDGLT 60

Query: 63 VTA--LKVSAEE 72
          ++    +VS++ 
Sbjct: 61 LSPKKFRVSSKR 72


>UniRef50_C8S5L7 Putative uncharacterized protein n=1 Tax=Rhodobacter sp. SW2
           RepID=C8S5L7_9RHOB
          Length = 151

 Score = 54.0 bits (129), Expect = 1e-05,   Method: Composition-based stats.
 Identities = 22/73 (30%), Positives = 36/73 (49%), Gaps = 3/73 (4%)

Query: 252 VASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELP---RAETARQALNASRLI 308
             +DL+ QAEHG +S V L+T    +A RV   V   +  LP   RA  A    + + +I
Sbjct: 16  ATADLVGQAEHGYNSPVWLVTSDRGLAARVTALVPELIVALPEPNRASAAAAWADLAEVI 75

Query: 309 VTKDLAQCVEISN 321
           + +D  +   + +
Sbjct: 76  LCEDAEEMARVFD 88


>UniRef50_B8FPV4 Putative cell wall binding repeat 2-containing protein n=2
           Tax=Desulfitobacterium hafniense RepID=B8FPV4_DESHD
          Length = 530

 Score = 40.9 bits (95), Expect = 0.096,   Method: Composition-based stats.
 Identities = 29/136 (21%), Positives = 55/136 (40%), Gaps = 26/136 (19%)

Query: 157 VVLCSPPPIADEILYAAQLCGVQDVFNVGGAQAIAA------LAFGTESVPKVDKIFGPG 210
           +++ S   +++E+L+     G + V+ +GG  AI+A        FG  +     ++ G  
Sbjct: 275 ILMTSSQRLSNEVLHEILNLGAETVYMIGGTGAISAEIESELQTFGITT----QRLAGA- 329

Query: 211 NAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVIL 270
           N + T A+           I    GPS+ + +A     PD +A    + A+       IL
Sbjct: 330 NRYDTAAQ-----------IAELVGPSDRVYLAYGYGEPDAIAVSSFAAAQ----GASIL 374

Query: 271 LTPAADMARRVAEAVE 286
           LT    +       ++
Sbjct: 375 LTDTHSLPEETQNRLK 390


  Database: uniref50.fasta
    Posted date:  Mar 8, 2010 10:38 AM
  Number of letters in database: 1,040,396,356
  Number of sequences in database:  3,077,464
  
Lambda     K      H
   0.313    0.169    0.537 

Lambda     K      H
   0.267   0.0516    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 3,302,326,148
Number of Sequences: 3077464
Number of extensions: 183922756
Number of successful extensions: 481131
Number of sequences better than 1.0e-01: 154
Number of HSP's better than  0.1 without gapping: 446
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 478823
Number of HSP's gapped (non-prelim): 487
length of query: 434
length of database: 1,040,396,356
effective HSP length: 132
effective length of query: 302
effective length of database: 634,171,108
effective search space: 191519674616
effective search space used: 191519674616
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.1 bits)
S2: 95 (40.9 bits)
