BLASTP 2.2.22 [Sep-27-2009]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.


Reference for composition-based statistics:
Schaffer, Alejandro A., L. Aravind, Thomas L. Madden,
Sergei Shavirin, John L. Spouge, Yuri I. Wolf,  
Eugene V. Koonin, and Stephen F. Altschul (2001), 
"Improving the accuracy of PSI-BLAST protein database searches with 
composition-based statistics and other refinements",  Nucleic Acids Res. 29:2994-3005.

Query= batch____
         (434 letters)

Database: uniref50.fasta 
           3,077,464 sequences; 1,040,396,356 total letters

Searching..................................................done


Results from round 1


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

UniRef50_Q5E638 Histidinol dehydrogenase n=29 Tax=Bacteria RepID...   607   e-172
UniRef50_Q4QN74 Histidinol dehydrogenase n=38 Tax=cellular organ...   585   e-165
UniRef50_Q492K3 Histidinol dehydrogenase n=542 Tax=Proteobacteri...   585   e-165
UniRef50_P62456 Histidinol dehydrogenase n=127 Tax=Bacteria RepI...   582   e-165
UniRef50_D1PYE8 Histidinol dehydrogenase n=2 Tax=Prevotella RepI...   580   e-164
UniRef50_P59398 Histidinol dehydrogenase n=5 Tax=Buchnera aphidi...   579   e-164
UniRef50_O26327 Histidinol dehydrogenase n=6 Tax=Euryarchaeota R...   576   e-163
UniRef50_UPI00019859BD PREDICTED: hypothetical protein n=1 Tax=V...   574   e-162
UniRef50_Q8R882 Histidinol dehydrogenase n=7 Tax=Clostridia RepI...   573   e-162
UniRef50_D1IQ57 Histidinol dehydrogenase (Fragment) n=1 Tax=Viti...   573   e-162
UniRef50_Q39YP7 Histidinol dehydrogenase n=54 Tax=Bacteria RepID...   572   e-162
UniRef50_Q465R4 Histidinol dehydrogenase n=7 Tax=Euryarchaeota R...   571   e-161
UniRef50_Q58851 Histidinol dehydrogenase n=16 Tax=Euryarchaeota ...   569   e-161
UniRef50_Q722Y3 Histidinol dehydrogenase n=20 Tax=Firmicutes Rep...   568   e-160
UniRef50_A8RCE7 Putative uncharacterized protein n=1 Tax=Eubacte...   567   e-160
UniRef50_Q9C5U8 Histidinol dehydrogenase, chloroplastic n=34 Tax...   566   e-160
UniRef50_Q02136 Histidinol dehydrogenase n=9 Tax=Bacteria RepID=...   565   e-159
UniRef50_Q30TA4 Histidinol dehydrogenase n=16 Tax=Epsilonproteob...   564   e-159
UniRef50_D1CF70 Histidinol dehydrogenase n=1 Tax=Thermobaculum t...   564   e-159
UniRef50_Q8YSM8 Histidinol dehydrogenase 1 n=16 Tax=Bacteria Rep...   561   e-158
UniRef50_C0GFZ9 Histidinol dehydrogenase n=1 Tax=Dethiobacter al...   560   e-158
UniRef50_Q46J19 Histidinol dehydrogenase n=60 Tax=Bacteria RepID...   559   e-158
UniRef50_C6Y3G2 Histidinol dehydrogenase n=6 Tax=cellular organi...   559   e-158
UniRef50_Q6FEC8 Histidinol dehydrogenase n=50 Tax=Bacteria RepID...   557   e-157
UniRef50_B0TY46 Histidinol dehydrogenase n=2 Tax=Francisella phi...   557   e-157
UniRef50_Q4ZNV9 Histidinol dehydrogenase n=116 Tax=Bacteria RepI...   554   e-156
UniRef50_P59399 Histidinol dehydrogenase n=14 Tax=Bacteria RepID...   553   e-156
UniRef50_D0RRH1 Histidinol dehydrogenase n=1 Tax=alpha proteobac...   552   e-156
UniRef50_D0JBA3 Histidinol dehydrogenase n=2 Tax=Blattabacterium...   552   e-156
UniRef50_A9NV24 Histidinol dehydrogenase n=2 Tax=Spermatophyta R...   552   e-156
UniRef50_B9D1F9 Histidinol dehydrogenase n=2 Tax=Campylobacter R...   550   e-155
UniRef50_P00815 Histidinol dehydrogenase n=17 Tax=cellular organ...   550   e-155
UniRef50_Q2NHT1 HisD n=1 Tax=Methanosphaera stadtmanae DSM 3091 ...   548   e-154
UniRef50_C9LTV1 Histidinol dehydrogenase n=1 Tax=Selenomonas spu...   547   e-154
UniRef50_C0QG33 Histidinol dehydrogenase n=4 Tax=Deltaproteobact...   545   e-153
UniRef50_C9KKX1 Histidinol dehydrogenase n=1 Tax=Mitsuokella mul...   544   e-153
UniRef50_B2KCM4 Histidinol dehydrogenase n=1 Tax=Elusimicrobium ...   543   e-153
UniRef50_Q5FS83 Histidinol dehydrogenase n=3 Tax=Bacteria RepID=...   542   e-152
UniRef50_Q1Q2D0 Histidinol dehydrogenase n=1 Tax=Candidatus Kuen...   541   e-152
UniRef50_D2RJQ0 Histidinol dehydrogenase n=7 Tax=Firmicutes RepI...   539   e-152
UniRef50_B2A652 Histidinol dehydrogenase n=1 Tax=Natranaerobius ...   538   e-151
UniRef50_B3WED5 Histidinol dehydrogenase n=21 Tax=Bacilli RepID=...   538   e-151
UniRef50_C4V2I6 Histidinol dehydrogenase n=1 Tax=Selenomonas flu...   537   e-151
UniRef50_C3XDE7 Histidinol dehydrogenase n=1 Tax=Helicobacter bi...   537   e-151
UniRef50_Q2PPB3 Histidine biosynthesis trifunctional protein n=1...   537   e-151
UniRef50_Q3J079 Histidinol dehydrogenase 1 n=26 Tax=Proteobacter...   536   e-151
UniRef50_B3TCH3 Putative Histidinol dehydrogenase n=1 Tax=uncult...   536   e-151
UniRef50_C1PFR7 Histidinol dehydrogenase n=1 Tax=Bacillus coagul...   535   e-151
UniRef50_Q3AR25 Histidinol dehydrogenase n=13 Tax=Bacteria RepID...   535   e-150
UniRef50_Q313T7 Histidinol dehydrogenase n=7 Tax=Deltaproteobact...   534   e-150
UniRef50_Q186D5 Histidinol dehydrogenase n=9 Tax=Bacteria RepID=...   533   e-150
UniRef50_Q46WL2 Histidinol dehydrogenase 1 n=202 Tax=Bacteria Re...   531   e-149
UniRef50_Q5ZW87 Histidinol dehydrogenase n=6 Tax=Legionella RepI...   530   e-149
UniRef50_C7LV94 Histidinol dehydrogenase n=6 Tax=Desulfovibriona...   530   e-149
UniRef50_P62457 Histidinol dehydrogenase n=27 Tax=cellular organ...   529   e-149
UniRef50_D1YWF4 Histidinol dehydrogenase n=1 Tax=Methanocella pa...   528   e-148
UniRef50_Q4FQF8 Histidinol dehydrogenase n=6 Tax=Proteobacteria ...   527   e-148
UniRef50_A9A0A6 Histidinol dehydrogenase n=2 Tax=Desulfobacterac...   523   e-147
UniRef50_Q9X0D1 Histidinol dehydrogenase n=6 Tax=Thermotogaceae ...   522   e-147
UniRef50_B9KYT3 Histidinol dehydrogenase n=1 Tax=Thermomicrobium...   521   e-146
UniRef50_Q9P777 Histidinol dehydrogenase n=71 Tax=cellular organ...   518   e-145
UniRef50_Q3B5E3 Histidinol dehydrogenase n=8 Tax=Chlorobiaceae R...   517   e-145
UniRef50_Q4P7D9 Putative uncharacterized protein n=3 Tax=Eukaryo...   515   e-144
UniRef50_Q87C29 Histidinol dehydrogenase n=66 Tax=cellular organ...   515   e-144
UniRef50_Q3ZXL7 Histidinol dehydrogenase n=5 Tax=Dehalococcoides...   515   e-144
UniRef50_B3DXR9 Histidinol dehydrogenase n=1 Tax=Methylacidiphil...   513   e-144
UniRef50_A5D1M4 Histidinol dehydrogenase n=1 Tax=Pelotomaculum t...   511   e-143
UniRef50_A3EUM9 Histidinol dehydrogenase n=3 Tax=Leptospirillum ...   510   e-143
UniRef50_C7NG13 Histidinol dehydrogenase n=2 Tax=Bacteria RepID=...   510   e-143
UniRef50_C8WUX6 Histidinol dehydrogenase n=2 Tax=Alicyclobacillu...   506   e-142
UniRef50_P62460 Histidinol dehydrogenase n=15 Tax=Bacteria RepID...   506   e-142
UniRef50_Q4A044 Histidinol dehydrogenase n=62 Tax=Staphylococcus...   501   e-140
UniRef50_Q4FNE2 Histidinol dehydrogenase 1 n=3 Tax=Candidatus Pe...   501   e-140
UniRef50_C9RN89 Histidinol dehydrogenase n=1 Tax=Fibrobacter suc...   500   e-140
UniRef50_D0LM64 Histidinol dehydrogenase n=2 Tax=Nannocystineae ...   500   e-140
UniRef50_B1YL14 Histidinol dehydrogenase n=1 Tax=Exiguobacterium...   499   e-139
UniRef50_Q01ZU1 Histidinol dehydrogenase n=1 Tax=Candidatus Soli...   497   e-139
UniRef50_UPI00016BFCCC histidinol dehydrogenase n=1 Tax=Epulopis...   493   e-138
UniRef50_C4L171 Histidinol dehydrogenase n=1 Tax=Exiguobacterium...   492   e-137
UniRef50_Q5WIU9 Histidinol dehydrogenase 1 n=52 Tax=cellular org...   491   e-137
UniRef50_Q67KH6 Histidinol dehydrogenase n=1 Tax=Symbiobacterium...   491   e-137
UniRef50_B1H0F0 Histidinol dehydrogenase n=1 Tax=uncultured Term...   489   e-137
UniRef50_D1N997 Histidinol dehydrogenase n=2 Tax=Lentisphaerae R...   487   e-136
UniRef50_Q7UX39 Histidinol dehydrogenase n=6 Tax=Planctomycetace...   486   e-136
UniRef50_A6UA68 Histidinol dehydrogenase n=4 Tax=Proteobacteria ...   486   e-136
UniRef50_Q8TXG3 Histidinol dehydrogenase n=1 Tax=Methanopyrus ka...   485   e-135
UniRef50_Q483H8 Histidinol dehydrogenase 2 n=15 Tax=Proteobacter...   485   e-135
UniRef50_A1ZJE8 Histidinol dehydrogenase n=1 Tax=Microscilla mar...   483   e-135
UniRef50_UPI00017455E1 Histidinol dehydrogenase n=1 Tax=Verrucom...   482   e-134
UniRef50_B3T638 Histidinol dehydrogenase n=1 Tax=uncultured mari...   482   e-134
UniRef50_C0G418 Histidinol dehydrogenase n=2 Tax=Rhizobiales Rep...   481   e-134
UniRef50_Q13I58 Histidinol dehydrogenase n=22 Tax=cellular organ...   481   e-134
UniRef50_P73058 Histidinol dehydrogenase 1 n=11 Tax=Cyanobacteri...   479   e-133
UniRef50_D0XPF3 Histidinol dehydrogenase n=1 Tax=Brevundimonas s...   476   e-132
UniRef50_Q4JW59 Histidinol dehydrogenase n=104 Tax=Actinobacteri...   474   e-132
UniRef50_B4W8G9 Histidinol dehydrogenase n=2 Tax=Caulobacteracea...   472   e-131
UniRef50_A4QA32 Histidinol dehydrogenase n=16 Tax=cellular organ...   471   e-131
UniRef50_Q64EP7 Histidinol dehydrogenase n=2 Tax=environmental s...   471   e-131
UniRef50_D2RSH8 Histidinol dehydrogenase n=1 Tax=Haloterrigena t...   470   e-131
UniRef50_Q1AX10 Histidinol dehydrogenase n=1 Tax=Rubrobacter xyl...   469   e-131
UniRef50_A3Q131 Histidinol dehydrogenase n=6 Tax=Mycobacterium R...   469   e-131
UniRef50_A9A5X6 Histidinol dehydrogenase n=2 Tax=Thaumarchaeota ...   468   e-130
UniRef50_D1B7M0 Histidinol dehydrogenase n=2 Tax=Bacteria RepID=...   468   e-130
UniRef50_B2UMH6 Histidinol dehydrogenase n=3 Tax=Verrucomicrobia...   466   e-130
UniRef50_B6A0U7 Histidinol dehydrogenase n=1 Tax=Rhizobium legum...   464   e-129
UniRef50_B0S9F2 Histidinol dehydrogenase n=6 Tax=Leptospira RepI...   464   e-129
UniRef50_D2R570 Histidinol dehydrogenase n=1 Tax=Pirellula stale...   463   e-129
UniRef50_Q2HFX2 Putative uncharacterized protein n=1 Tax=Chaetom...   463   e-129
UniRef50_Q3IQR5 Histidinol dehydrogenase n=10 Tax=Halobacteriace...   463   e-129
UniRef50_Q5JFR5 Histidinol dehydrogenase n=9 Tax=cellular organi...   461   e-128
UniRef50_C1FAE2 Histidinol dehydrogenase n=1 Tax=Acidobacterium ...   461   e-128
UniRef50_Q82AA6 Histidinol dehydrogenase n=29 Tax=Actinobacterid...   461   e-128
UniRef50_C0GVA3 Histidinol dehydrogenase n=1 Tax=Desulfonatronos...   457   e-127
UniRef50_Q5YYQ0 Histidinol dehydrogenase n=8 Tax=Actinomycetales...   456   e-127
UniRef50_Q1D4L9 Histidinol dehydrogenase n=2 Tax=Cystobacterinea...   456   e-126
UniRef50_B8E2C3 Histidinol dehydrogenase n=1 Tax=Dictyoglomus tu...   455   e-126
UniRef50_B5YE85 Histidinol dehydrogenase n=1 Tax=Dictyoglomus th...   454   e-126
UniRef50_O33775 Histidinol dehydrogenase n=12 Tax=Sulfolobaceae ...   450   e-125
UniRef50_Q1IKB6 Histidinol dehydrogenase n=1 Tax=Candidatus Kori...   445   e-123
UniRef50_Q46N53 Histidinol dehydrogenase 2 n=50 Tax=root RepID=H...   444   e-123
UniRef50_C7LZ86 Histidinol dehydrogenase n=1 Tax=Acidimicrobium ...   441   e-122
UniRef50_A9G5W4 HisD protein n=1 Tax=Sorangium cellulosum 'So ce...   438   e-121
UniRef50_Q0AP81 Histidinol dehydrogenase, Histidinol-phosphatase...   436   e-121
UniRef50_A0R401 Histidinol dehydrogenase n=2 Tax=Actinomycetales...   431   e-119
UniRef50_C7RAI8 Histidinol dehydrogenase n=1 Tax=Kangiella koree...   426   e-118
UniRef50_B1ZNB2 Histidinol dehydrogenase n=3 Tax=Verrucomicrobia...   424   e-117
UniRef50_C1A4M1 Histidinol dehydrogenase n=1 Tax=Gemmatimonas au...   419   e-116
UniRef50_C9SQK1 Histidine biosynthesis trifunctional protein n=1...   412   e-113
UniRef50_B5YLM0 Histidinol dehydrogenase n=1 Tax=Thalassiosira p...   404   e-111
UniRef50_UPI0001C3165E histidinol dehydrogenase n=1 Tax=Conexiba...   388   e-106
UniRef50_C6UN35 Histidinal/histidinol dehydrogenase n=1 Tax=Cand...   380   e-104
UniRef50_A8M914 Histidinol dehydrogenase n=1 Tax=Caldivirga maqu...   378   e-103
UniRef50_B7FPZ7 Histidinol dehydrogenase (Fragment) n=3 Tax=Euka...   377   e-103
UniRef50_A8A9G5 Histidinol dehydrogenase n=1 Tax=Ignicoccus hosp...   341   3e-92
UniRef50_B9NIZ3 Histidinol dehydrogenase n=1 Tax=Populus trichoc...   327   8e-88
UniRef50_P72946 Putative histidinol dehydrogenase 2 n=1 Tax=Syne...   319   1e-85
UniRef50_Q8ZY17 Histidinol dehydrogenase n=5 Tax=Thermoproteacea...   298   3e-79
UniRef50_B8NVQ6 Histidinol dehydrogenase, putative n=1 Tax=Asper...   224   5e-57
UniRef50_UPI0001909A69 histidinol dehydrogenase n=1 Tax=Rhizobiu...   211   3e-53
UniRef50_C5GHZ5 Histidinol dehydrogenase n=2 Tax=Ajellomyces der...   209   2e-52
UniRef50_C7H2J0 Histidinol dehydrogenase n=1 Tax=Faecalibacteriu...   205   2e-51
UniRef50_A3J633 Histidinol dehydrogenase (Fragment) n=1 Tax=Flav...   159   2e-37
UniRef50_B4CYY3 NAD+ oxidoreductase n=1 Tax=Chthoniobacter flavu...   133   1e-29
UniRef50_UPI0001696B01 histidinol dehydrogenase n=2 Tax=Listeria...   120   1e-25
UniRef50_D1ND55 Histidinol dehydrogenase (Fragment) n=1 Tax=Haem...   111   6e-23
UniRef50_D1KBK9 Histidinol dehydrogenase n=1 Tax=uncultured SUP0...    96   3e-18
UniRef50_C7ZHH7 Putative uncharacterized protein n=1 Tax=Nectria...    81   7e-14
UniRef50_UPI00016988E7 histidinol dehydrogenase n=1 Tax=Endorift...    66   2e-09
UniRef50_C0S8B7 Histidinol dehydrogenase n=1 Tax=Paracoccidioide...    63   2e-08
UniRef50_D2MHU6 Putative uncharacterized protein (Fragment) n=1 ...    58   7e-07
UniRef50_C8S5L7 Putative uncharacterized protein n=1 Tax=Rhodoba...    54   1e-05
UniRef50_B8FPV4 Putative cell wall binding repeat 2-containing p...    41   0.096

>UniRef50_Q5E638 Histidinol dehydrogenase n=29 Tax=Bacteria RepID=HISX_VIBF1
          Length = 439

 Score =  607 bits (1567), Expect = e-172,   Method: Composition-based stats.
 Identities = 275/429 (64%), Positives = 328/429 (76%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
              + W S +  QQ  +L RPAI+   +IT  V  +++ VK  GD  +   + KFD    
Sbjct: 1   MKTLVWQSLSDSQQDTVLQRPAITEGANITAAVTSVINTVKQEGDAGVFALTEKFDGVKP 60

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRP 123
            +++VS  EI AAS+RLS+E+K A+  A  NI  FH AQK  PV VETQPGV C+Q+T P
Sbjct: 61  DSIRVSNAEIEAASDRLSEEMKTALKQAYSNISKFHQAQKPQPVKVETQPGVICEQITMP 120

Query: 124 VASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVFN 183
           +  VGLYIPGGSAPL STVLML  PA IAGC KVVLCSPPPIADEILY A+LC + +V+N
Sbjct: 121 INKVGLYIPGGSAPLPSTVLMLGIPAQIAGCHKVVLCSPPPIADEILYVAKLCKIDEVYN 180

Query: 184 VGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIA 243
           +GGAQA+AA+A+GTESV KVDKIFGPGNA+VTEAKRQVS    GAAIDMPAGPSEVLVIA
Sbjct: 181 IGGAQAVAAMAYGTESVSKVDKIFGPGNAYVTEAKRQVSNDFRGAAIDMPAGPSEVLVIA 240

Query: 244 DSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALN 303
           D  A PDF+A+DLLSQAEHGPDSQV+L+TP+  +A +VA+AVERQL EL R + ARQAL 
Sbjct: 241 DESADPDFIAADLLSQAEHGPDSQVVLVTPSPIIADQVADAVERQLKELSREDIARQALG 300

Query: 304 ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYAS 363
           +S LIV   L QCV ISN YGPEHLI+QT+N REL+  + +AGS+FLGD+SPESAGDYAS
Sbjct: 301 SSLLIVADSLTQCVSISNFYGPEHLIVQTKNPRELLPLLDNAGSIFLGDYSPESAGDYAS 360

Query: 364 GTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAV 423
           GTNHVLPTYGYT T SSLGLADF KRMTVQEL+ +G   LA T+ T+A AE L AHK AV
Sbjct: 361 GTNHVLPTYGYTRTYSSLGLADFSKRMTVQELTADGLKGLAPTVVTMAEAEGLDAHKRAV 420

Query: 424 TLRVNALKE 432
           T+R+  L +
Sbjct: 421 TIRIEKLAQ 429


>UniRef50_Q4QN74 Histidinol dehydrogenase n=38 Tax=cellular organisms
           RepID=HISX_HAEI8
          Length = 427

 Score =  585 bits (1509), Expect = e-165,   Method: Composition-based stats.
 Identities = 274/429 (63%), Positives = 330/429 (76%), Gaps = 3/429 (0%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
             TII WN  +  ++R+++MRP     E+I + VN I +NV   GD AL E   KFD   
Sbjct: 1   MQTII-WNHLSETEKRKVIMRPVQQNGENIQQAVNAIRENVAYNGDRALFELCEKFDGVK 59

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
           +  L VSA+EI AAS R+S +L+ A+  A  NIE FH AQ+   +D+E Q GVRCQ VTR
Sbjct: 60  LDKLIVSADEIQAASSRISVKLRNAIEQAKTNIEAFHKAQQNQEIDLEIQEGVRCQVVTR 119

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVF 182
           P++ VGLYIPGGSAPLFSTVLMLA PA IAGCKK+VLCSPPPI+DEILY A LCGV+ ++
Sbjct: 120 PISCVGLYIPGGSAPLFSTVLMLAIPAKIAGCKKIVLCSPPPISDEILYTAHLCGVETIY 179

Query: 183 NVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVI 242
            +GGAQA+ A+A GTESV KVDKIFGPGNAFVTEAKRQV+Q  +  AIDMPAGPSEVLVI
Sbjct: 180 AIGGAQAVFAMAQGTESVAKVDKIFGPGNAFVTEAKRQVAQ--NSTAIDMPAGPSEVLVI 237

Query: 243 ADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL 302
           AD  A P+FVASDLLSQAEHG DSQVIL+     +A+  A A+ERQLA LPRAETAR+AL
Sbjct: 238 ADESADPEFVASDLLSQAEHGADSQVILVATCETLAKETALAIERQLALLPRAETARKAL 297

Query: 303 NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYA 362
           N SR+ + + L Q VEISN+Y PEHLI+QT+NAR+L+  + +AGS+FLG +SPES GDYA
Sbjct: 298 NHSRIFIAESLEQAVEISNEYAPEHLIVQTKNARKLLPYLDNAGSIFLGAYSPESMGDYA 357

Query: 363 SGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNA 422
           SGTNHVLPTYGYT T SSLGLADF KRMTVQEL+ +GF  LA T+E +A AE+L AHK A
Sbjct: 358 SGTNHVLPTYGYTKTYSSLGLADFSKRMTVQELTPKGFKNLAETVEVMAEAEQLAAHKMA 417

Query: 423 VTLRVNALK 431
           V++R+  L 
Sbjct: 418 VSVRLAKLN 426


>UniRef50_Q492K3 Histidinol dehydrogenase n=542 Tax=Proteobacteria RepID=HISX_BLOPB
          Length = 443

 Score =  585 bits (1508), Expect = e-165,   Method: Composition-based stats.
 Identities = 232/427 (54%), Positives = 305/427 (71%)

Query: 7   IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTAL 66
           I WN C+  +Q++LL RP  +    I   V +IL  V   GD AL +++  FD    T L
Sbjct: 10  IYWNDCSKSEQKKLLTRPINNKLNDIYINVKNILTKVYNEGDRALFKFNFDFDNVQTTQL 69

Query: 67  KVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVAS 126
           ++  E I  +   LS+E+KQA+  A+ NI  FH AQ    + VET PGV CQQ+ RP+  
Sbjct: 70  QIPTEIIMNSGRNLSNEIKQAIHTAMTNITRFHQAQCYSEIIVETLPGVYCQQIIRPLNI 129

Query: 127 VGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVFNVGG 186
           VGLY+PGG+APL STV+ML  PA IA CK+V+LCSPPPI D I+Y AQLCG+ +++ +GG
Sbjct: 130 VGLYVPGGTAPLLSTVMMLGVPARIAKCKRVILCSPPPIPDVIIYTAQLCGIDEIYQIGG 189

Query: 187 AQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSG 246
           +Q+IAA+ FGTES+PKVDKIFGPGN +VTEAKRQ++   +GAAIDM AGPSE+L+IAD+ 
Sbjct: 190 SQSIAAMGFGTESIPKVDKIFGPGNIWVTEAKRQINLAPNGAAIDMLAGPSEILIIADNT 249

Query: 247 ATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASR 306
           A P F+A+DLLSQ+EHGPDS  IL+TP + +A +  + + +QL  LPR +  R  L  SR
Sbjct: 250 ANPIFIAADLLSQSEHGPDSHAILITPYSCIAEKTKKELHKQLKILPRNDIVRNVLLNSR 309

Query: 307 LIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTN 366
           +I+T +L +C  ISN Y PEHLIIQ  NA + +  IT+AGS+FLG+WSPE+AGDYASG N
Sbjct: 310 MIITNNLMECFSISNSYAPEHLIIQIENASDYLHYITNAGSIFLGNWSPETAGDYASGPN 369

Query: 367 HVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
           HVLPTYG     S LG+ DFQKRM+VQ+L++ G   L+STI TL   E+L AH+ A+T R
Sbjct: 370 HVLPTYGRAVATSGLGVIDFQKRMSVQQLTQNGLLQLSSTITTLTQIEQLKAHEYAITHR 429

Query: 427 VNALKEQ 433
           +N +KEQ
Sbjct: 430 INYIKEQ 436


>UniRef50_P62456 Histidinol dehydrogenase n=127 Tax=Bacteria RepID=HISX_BACC1
          Length = 429

 Score =  582 bits (1501), Expect = e-165,   Method: Composition-based stats.
 Identities = 169/417 (40%), Positives = 250/417 (59%), Gaps = 7/417 (1%)

Query: 19  QLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASE 78
           +LL   A    E++ R V++I+ NV+  GDEAL  Y+ KFD   +   +VS EE   AS 
Sbjct: 16  KLLRENANIIEETVQRNVSEIVRNVRESGDEALSFYTKKFDGVKIKEFRVSEEEEKRASM 75

Query: 79  RLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPL 138
            + +   +A+  A KNI ++H  QK   +      G+   Q+ RP+ +VG+Y+PGG+A  
Sbjct: 76  FVENSFLEALQEAKKNIISYHEKQKRQSMFDCASEGIIRGQIIRPLENVGVYVPGGTASY 135

Query: 139 FSTVLMLATPASIAGCKKVVLCSPP---PIADEILYAAQLCGVQDVFNVGGAQAIAALAF 195
            S+VLM   PA +AG KK+V+ +PP    I   IL AA L GV +++ +GGAQAIAALA+
Sbjct: 136 PSSVLMNVLPAKLAGVKKIVMVTPPREGGIDPHILVAASLAGVDEIYTIGGAQAIAALAY 195

Query: 196 GTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASD 255
           GTES+PKVDKI GPGN +V  AKR+V   ++   IDM AGPSE++VIAD      ++A+D
Sbjct: 196 GTESIPKVDKIVGPGNLYVALAKREVYGIVN---IDMIAGPSEIVVIADETGNAKYIAAD 252

Query: 256 LLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALN-ASRLIVTKDLA 314
           LLSQAEH   +  I +T   ++A++V + +ERQL  LPR+E AR+++N    + +   + 
Sbjct: 253 LLSQAEHDERATAICITTNIELAKKVEKEIERQLETLPRSEIARESINRNGAIFIVPSID 312

Query: 315 QCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGY 374
           + +++SN+  PEHL +  +     +  +  AGS+FLG ++PE  GDY +G NHVLPT G 
Sbjct: 313 EALQLSNEIAPEHLELHIKEPMNALAYVKHAGSIFLGPYAPEPLGDYLAGPNHVLPTSGT 372

Query: 375 TATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNALK 431
               S L + DF K+ +    ++E    +   I  LA  E L AH  A+ +R    +
Sbjct: 373 ARFFSPLSVDDFVKKSSFLSYTEEALRDVQHHIVELANKEGLHAHARAIQIRFEEEE 429


>UniRef50_D1PYE8 Histidinol dehydrogenase n=2 Tax=Prevotella RepID=D1PYE8_9BACT
          Length = 444

 Score =  580 bits (1496), Expect = e-164,   Method: Composition-based stats.
 Identities = 212/432 (49%), Positives = 287/432 (66%), Gaps = 9/432 (2%)

Query: 6   IIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA 65
           II +   +  +  ++L RP +  S  +  TVN+IL +VK+RGDEA+R Y A FD+  +  
Sbjct: 3   IIKYPPKS--EWSRILKRPHLDVS-QLNETVNEILSDVKSRGDEAVRHYEALFDQADLGD 59

Query: 66  LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVA 125
           L VS EEI  A   +S +LK+A+ +A  NI  FH +Q      VET  GV C Q +  + 
Sbjct: 60  LTVSDEEIDEAMSMVSTDLKEALELAYHNISKFHESQLFHGKMVETAQGVVCWQKSVAIE 119

Query: 126 SVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQDV 181
            VGLYIPGG+APLFSTVLMLATPA IAGCK +VLC+PP     I   IL AA + GV  +
Sbjct: 120 KVGLYIPGGTAPLFSTVLMLATPAKIAGCKDIVLCTPPNHDGKIHPAILVAAHIAGVDRI 179

Query: 182 FNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLV 241
           F  GG QAI A+A+GT+++PKV KIFGPGN +V  AK+QVS  L   AIDMPAGPSEV V
Sbjct: 180 FKAGGVQAIGAMAYGTQTIPKVYKIFGPGNQYVMAAKQQVS--LHDVAIDMPAGPSEVCV 237

Query: 242 IADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQA 301
           IAD G+  +FVA+DLLSQAEHG DSQV+L++ + ++   V   VERQL  LPR E A  A
Sbjct: 238 IADEGSNAEFVAADLLSQAEHGSDSQVMLISTSDNLITEVRSQVERQLENLPRREIASDA 297

Query: 302 LNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDY 361
           L  S+ ++  D+ + + +SN+Y PEHLI+ T N  E+ D + +AGSVF+G WS ESAGDY
Sbjct: 298 LKNSKFVLVHDMDEAMRLSNEYAPEHLILSTGNFEEMADKVVNAGSVFMGKWSCESAGDY 357

Query: 362 ASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKN 421
           ASGTNH LPT+ Y    S + L  + +++T Q+LS+ G S++ + +  +A  E L AH +
Sbjct: 358 ASGTNHTLPTHQYALAYSGVNLDSYCRKITFQQLSENGVSSIGNAVVRMAEDEGLEAHAH 417

Query: 422 AVTLRVNALKEQ 433
           A+ +R+  + ++
Sbjct: 418 AMRIRLKKVDDK 429


>UniRef50_P59398 Histidinol dehydrogenase n=5 Tax=Buchnera aphidicola
           RepID=HISX_BUCBP
          Length = 435

 Score =  579 bits (1494), Expect = e-164,   Method: Composition-based stats.
 Identities = 215/431 (49%), Positives = 305/431 (70%)

Query: 2   SFNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKT 61
            +  II W SC+ +++R++L RP ++ +  I   V +I+ NVK  GD+AL +Y+  FDK 
Sbjct: 3   VYIPIIYWKSCSEKEKREILFRPVVNDNSQIKEVVKEIITNVKNSGDKALYDYTKTFDKI 62

Query: 62  TVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVT 121
            + +++VS  EI  +   +++E++++++VA  NI+ FH  Q    V++E QPGV C+Q+ 
Sbjct: 63  RLESIQVSYGEIVDSDSFVNEEIQKSISVAKNNIKIFHEKQTHNVVNIEIQPGVFCRQII 122

Query: 122 RPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDV 181
           RP+ SVGLYIPGG APL STVLMLA PA I GCK ++LCSPPPI  EILYA+++CG+ ++
Sbjct: 123 RPIQSVGLYIPGGCAPLVSTVLMLAIPAKIVGCKNIILCSPPPITKEILYASKICGIHNI 182

Query: 182 FNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLV 241
           F VGGAQAIAA+AFGT+++PKV+KIFGPGN +VTEAK Q++  L+  +IDM AGPSE+L+
Sbjct: 183 FQVGGAQAIAAMAFGTKTIPKVNKIFGPGNVYVTEAKLQINALLNDLSIDMLAGPSEILI 242

Query: 242 IADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQA 301
           IAD  A    +ASD LSQ EHG  SQ IL+TP+ D+A  V   +  QL  L R +   ++
Sbjct: 243 IADFKANACIIASDFLSQMEHGIYSQAILVTPSYDLACNVIFEINIQLKNLSRKKVINKS 302

Query: 302 LNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDY 361
           L  SR+IVTK L +C EISN Y PEHLIIQ  N+  L+  + +AGS+FLG WS  ++GDY
Sbjct: 303 LKYSRIIVTKTLLECFEISNLYAPEHLIIQCENSNRLLVYVINAGSIFLGRWSAVASGDY 362

Query: 362 ASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKN 421
            +GTNHVLPTYG     S L + DFQK ++VQ+L ++G   ++S+I +L+  ER+ AH N
Sbjct: 363 VTGTNHVLPTYGSAIVNSGLTVMDFQKIISVQKLDQQGLIDVSSSIISLSEVERMDAHTN 422

Query: 422 AVTLRVNALKE 432
           ++  R+ AL++
Sbjct: 423 SIKQRLIALQD 433


>UniRef50_O26327 Histidinol dehydrogenase n=6 Tax=Euryarchaeota RepID=HISX_METTH
          Length = 426

 Score =  576 bits (1485), Expect = e-163,   Method: Composition-based stats.
 Identities = 181/430 (42%), Positives = 256/430 (59%), Gaps = 9/430 (2%)

Query: 5   TIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVT 64
            ++        +  +L+ R  +     +   V DI+  V+  GD+ALRE + +FD  TV 
Sbjct: 1   MLMKITEFDYRRISELVERARLDVD-DVLGPVADIISMVRDGGDDALRELTGRFDGVTVE 59

Query: 65  ALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPV 124
             +VS EEI  A + L   +K+A+  A  NIE FH  Q       E +PGV   Q+ RP+
Sbjct: 60  NFRVSREEIEEAHKNLEPGVKEALREAASNIEEFHRMQMPSGWMSEVRPGVMAGQLVRPI 119

Query: 125 ASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQD 180
            SVG YIPGG A   ST+LM   PA IAG +++V C+PP     + D +L AA + G  +
Sbjct: 120 DSVGCYIPGGRAVYPSTILMTVIPARIAGVERIVCCTPPAQDGSVPDAVLVAADMAGASE 179

Query: 181 VFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVL 240
           ++ VGGAQA+AA+A+GTE++  VDKI GPGN FVT AK+ V   +D   ID PAGPSEVL
Sbjct: 180 IYRVGGAQAVAAMAYGTETIRPVDKIVGPGNIFVTAAKKLVYGEVD---IDFPAGPSEVL 236

Query: 241 VIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQ 300
           +IAD  A+P+++A ++L+QAEH P +  +L+T + D+A  V E V   +  + RA   R+
Sbjct: 237 IIADETASPEYIALEILAQAEHDPQAASVLVTDSRDLALEVKEMVHENIKYMERANIIRE 296

Query: 301 ALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAG 359
           +L     +++T D+ + V+ SN Y PEHL+I T +  E ++ I +AGS+FLG+ SP +AG
Sbjct: 297 SLERYGMIVLTADIDEAVDFSNAYAPEHLVIMTDSPEETLEGIRNAGSIFLGELSPVAAG 356

Query: 360 DYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAH 419
           DY SGTNHVLPT G     S L    F K+ TVQ ++KEG   L  T+  LA  E L AH
Sbjct: 357 DYGSGTNHVLPTSGCARMYSGLSTESFIKKPTVQRITKEGLRNLQGTVLKLAEYEGLHAH 416

Query: 420 KNAVTLRVNA 429
             +   R+  
Sbjct: 417 AESFRRRLRD 426


>UniRef50_UPI00019859BD PREDICTED: hypothetical protein n=1 Tax=Vitis vinifera
           RepID=UPI00019859BD
          Length = 524

 Score =  574 bits (1480), Expect = e-162,   Method: Composition-based stats.
 Identities = 207/435 (47%), Positives = 272/435 (62%), Gaps = 8/435 (1%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
                 +  +  +   L  RP I  S SI   V+ I+D+V++RGD A+++Y+ +FDK  +
Sbjct: 87  MKSYRLSELSQAEVNSLKARPRIDFS-SIFNVVHPIVDDVRSRGDAAVKDYTTRFDKVEL 145

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRP 123
             L  +  E+      L   +K+A  VA  NI  FH AQK     VE   GV+C++V R 
Sbjct: 146 DRLIENVAELPD--PELDAGIKEAFDVAYDNIFAFHAAQKSAEKIVENMKGVKCKRVARS 203

Query: 124 VASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQ 179
           +ASVGLY+PGG+A L ST LML+ PA IAGCK VVL +PP     I  E+LY A+  GV 
Sbjct: 204 IASVGLYVPGGTAVLPSTALMLSVPAQIAGCKTVVLATPPSQDGGICKEVLYCAKKAGVT 263

Query: 180 DVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEV 239
            +   GGAQAIAA+A+GT S PKV+KIFGPGN +VT AK  +       +IDMPAGPSEV
Sbjct: 264 HILKAGGAQAIAAMAWGTTSCPKVEKIFGPGNQYVTAAKMILQNSEAMVSIDMPAGPSEV 323

Query: 240 LVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADM-ARRVAEAVERQLAELPRAETA 298
           LVIAD  A P  +A+DLLSQAEHGPDSQV+L+     +  R + E + +Q   LPR E A
Sbjct: 324 LVIADKHANPVHIAADLLSQAEHGPDSQVVLVIAGDGVDLRAIEEEISKQCQSLPRGEFA 383

Query: 299 RQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESA 358
            +AL+ S  +  +++ + +  SN Y PEHLII  ++A +  + I +AGSVFLG W+PES 
Sbjct: 384 SKALSHSFTVFARNMVEAISFSNLYAPEHLIINVKDAEKWENFIENAGSVFLGQWTPESV 443

Query: 359 GDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTA 418
           GDYASGTNHVLPTYGY      L L  F K MTVQ L++EG   L   +E +A  E L A
Sbjct: 444 GDYASGTNHVLPTYGYARMYGGLSLDSFLKYMTVQSLTEEGLRKLGPYVEAMAEVEGLEA 503

Query: 419 HKNAVTLRVNALKEQ 433
           HK AVTLR+  ++ +
Sbjct: 504 HKRAVTLRLQDIEAR 518


>UniRef50_Q8R882 Histidinol dehydrogenase n=7 Tax=Clostridia RepID=HISX_THETN
          Length = 430

 Score =  573 bits (1479), Expect = e-162,   Method: Composition-based stats.
 Identities = 180/431 (41%), Positives = 266/431 (61%), Gaps = 10/431 (2%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              + D+           +   +   ++ I + V DI++NV+ R D+AL EY+  +D   
Sbjct: 1   MIEMFDFTKEVDIGIFNKIQNRSKLENKEIAKRVEDIIENVRERKDKALFEYTYMYDGIN 60

Query: 63  VTA--LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQV 120
           + +  +KV  EEI  A E + ++  +A+  A+KNI  FH  QK     ++ + G+   QV
Sbjct: 61  LNSETVKVKEEEIKRAYEEVKEDFLKALDKAIKNITEFHEKQKEKTW-MDFKEGIVYGQV 119

Query: 121 TRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCG 177
            RP++SVG+Y+PGG+A   S+VLM   PA +AG +++V+ SP     I+  +L AA   G
Sbjct: 120 LRPLSSVGIYVPGGTASYPSSVLMNGIPAKVAGVERIVMVSPAGKKGISPYVLVAADKIG 179

Query: 178 VQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPS 237
           +++++ +GGAQA+AALAFGTES+PKVDKI GPGN +V  AKR +   +D   IDM AGPS
Sbjct: 180 IKEIYKIGGAQAVAALAFGTESIPKVDKIVGPGNIYVAMAKRALYGYVD---IDMVAGPS 236

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAET 297
           E+LVIAD  A+P +VA+DLLSQAEH   +  IL+T + ++A +V + +ERQ+  L R E 
Sbjct: 237 EILVIADESASPKYVAADLLSQAEHDVMASSILVTTSKELAEKVKKEIERQMEYLERKEI 296

Query: 298 ARQALNA-SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPE 356
             ++L     +IV  +L + + I+N+  PEHL +   N  E++  I +AG+VFLG++SPE
Sbjct: 297 IAESLKNFGAIIVIDNLKEAIGIANEIAPEHLELVIENPFEILGEIKNAGAVFLGEFSPE 356

Query: 357 SAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERL 416
             GDY +G NHVLPT G     S L + DF K+M V   SKE  S++   + TLA AE L
Sbjct: 357 PLGDYLAGPNHVLPTSGTARFFSPLSVRDFVKKMNVLYYSKEALSSVKDDVITLAEAEEL 416

Query: 417 TAHKNAVTLRV 427
           TAH N+V +R 
Sbjct: 417 TAHANSVKVRF 427


>UniRef50_D1IQ57 Histidinol dehydrogenase (Fragment) n=1 Tax=Vitis vinifera
           RepID=D1IQ57_VITVI
          Length = 546

 Score =  573 bits (1477), Expect = e-162,   Method: Composition-based stats.
 Identities = 207/435 (47%), Positives = 272/435 (62%), Gaps = 8/435 (1%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
                 +  +  +   L  RP I  S SI   V+ I+D+V++RGD A+++Y+ +FDK  +
Sbjct: 109 MKSYRLSELSQAEVNSLKARPRIDFS-SIFNVVHPIVDDVRSRGDAAVKDYTTRFDKVEL 167

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRP 123
             L  +  E+      L   +K+A  VA  NI  FH AQK     VE   GV+C++V R 
Sbjct: 168 DRLIENVAELPD--PELDAGIKEAFDVAYDNIFAFHAAQKSAEKIVENMKGVKCKRVARS 225

Query: 124 VASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQ 179
           +ASVGLY+PGG+A L ST LML+ PA IAGCK VVL +PP     I  E+LY A+  GV 
Sbjct: 226 IASVGLYVPGGTAVLPSTALMLSVPAQIAGCKTVVLATPPSQDGGICKEVLYCAKKAGVT 285

Query: 180 DVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEV 239
            +   GGAQAIAA+A+GT S PKV+KIFGPGN +VT AK  +       +IDMPAGPSEV
Sbjct: 286 HILKAGGAQAIAAMAWGTTSCPKVEKIFGPGNQYVTAAKMILQNSEAMVSIDMPAGPSEV 345

Query: 240 LVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADM-ARRVAEAVERQLAELPRAETA 298
           LVIAD  A P  +A+DLLSQAEHGPDSQV+L+     +  R + E + +Q   LPR E A
Sbjct: 346 LVIADKHANPVHIAADLLSQAEHGPDSQVVLVIAGDGVDLRAIEEEISKQCQSLPRGEFA 405

Query: 299 RQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESA 358
            +AL+ S  +  +++ + +  SN Y PEHLII  ++A +  + I +AGSVFLG W+PES 
Sbjct: 406 SKALSHSFTVFARNMVEAISFSNLYAPEHLIINVKDAEKWENFIENAGSVFLGQWTPESV 465

Query: 359 GDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTA 418
           GDYASGTNHVLPTYGY      L L  F K MTVQ L++EG   L   +E +A  E L A
Sbjct: 466 GDYASGTNHVLPTYGYARMYGGLSLDSFLKYMTVQSLTEEGLRKLGPYVEAMAEVEGLEA 525

Query: 419 HKNAVTLRVNALKEQ 433
           HK AVTLR+  ++ +
Sbjct: 526 HKRAVTLRLQDIEAR 540


>UniRef50_Q39YP7 Histidinol dehydrogenase n=54 Tax=Bacteria RepID=HISX_GEOMG
          Length = 436

 Score =  572 bits (1476), Expect = e-162,   Method: Composition-based stats.
 Identities = 172/437 (39%), Positives = 251/437 (57%), Gaps = 10/437 (2%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT- 62
              +D      + +   ++         + + V DI+ +V+ARGDEAL EY+ +FD+   
Sbjct: 1   MKFLDIRDTNFDMEFAAILARGEETGREVEQVVLDIIADVRARGDEALLEYTRRFDRLEA 60

Query: 63  --VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQV 120
             V +L+V+ +E+  A  R+ DE   A+ +AV+ +  FH  QK        +P +   Q+
Sbjct: 61  DSVASLQVTEDEVDYAFARVKDEEIAALKLAVERVARFHEKQKQETWLSTGEPDILLGQM 120

Query: 121 TRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCG 177
             P+  VG+Y+PGG A   S+V+M A PA +AG  +VV+ +P P   I   +L AA+  G
Sbjct: 121 VTPLERVGIYVPGGKASYPSSVIMNAVPARVAGVGEVVMVAPTPGGEINPHVLVAARFSG 180

Query: 178 VQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPS 237
           V  +F +GGAQA+AALA+GT +VPKVDKI GPGN +V  AK+ V  ++    IDM AGPS
Sbjct: 181 VDRIFRLGGAQAVAALAYGTATVPKVDKITGPGNIYVATAKKLVFGQV---GIDMIAGPS 237

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAET 297
           E+LVI D   TP  +A+DLLSQAEH   +  IL+T       RVA  VERQLAEL R   
Sbjct: 238 EILVINDGSGTPAHIAADLLSQAEHDELASSILITTDRGFGERVAAEVERQLAELSRETI 297

Query: 298 ARQALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPE 356
           AR++      +IV   L + +  SN+  PEHL +   N  +++  I +AG++FLG ++PE
Sbjct: 298 ARRSWETYGAVIVAGSLDEAIAFSNRIAPEHLELAVTNPFDVLPKIRNAGAIFLGHFTPE 357

Query: 357 SAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERL 416
           +AGDY +G NH LPT G     S L + DF K+ ++   S+ G + L   I  +A  E L
Sbjct: 358 AAGDYLAGPNHTLPTGGTARFFSPLSVDDFVKKSSIVYFSESGLNRLGGGIVRIAELEGL 417

Query: 417 TAHKNAVTLRVNALKEQ 433
            AH  +V++R+    E 
Sbjct: 418 EAHGRSVSVRLKGEGEA 434


>UniRef50_Q465R4 Histidinol dehydrogenase n=7 Tax=Euryarchaeota RepID=HISX_METBF
          Length = 433

 Score =  571 bits (1472), Expect = e-161,   Method: Composition-based stats.
 Identities = 182/432 (42%), Positives = 252/432 (58%), Gaps = 10/432 (2%)

Query: 1   MSFNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDK 60
           M        +  +  + ++LL R   S  E + +TV+ +L +V+ +GD ALREY+AKFDK
Sbjct: 1   MVMMLFKKLSDVSEAEMQKLLSRG--SGLEDVAKTVSTVLSDVRTKGDSALREYTAKFDK 58

Query: 61  TTVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLP-PVDVETQPGVRCQQ 119
             +    VS EE   A   +S EL   +  A  NI  FH AQ       +E +PG+   Q
Sbjct: 59  VELANFGVSEEEFQQALSGISPELLDHLKSAAANIRAFHEAQLPKATWFMELKPGIVLGQ 118

Query: 120 VTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQL 175
              P+ SVG Y PGG A   STVLM   PA +AG ++V++C+PP     +    L AA++
Sbjct: 119 KATPLESVGAYAPGGRASYPSTVLMTVIPARVAGVEQVIVCTPPRPDGSVHPLTLAAAKV 178

Query: 176 CGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAG 235
            G   VF +GG QAI ++A+GTE+VPKVDKI GPGN FVT AK Q+    D A ID PAG
Sbjct: 179 AGADKVFKLGGVQAIGSMAYGTETVPKVDKIVGPGNVFVTAAKMQIR---DVAEIDFPAG 235

Query: 236 PSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRA 295
           PSEVL+IAD  A    VASD+L+Q+EH P+S  IL+T +  +A  V   V  Q  +  R+
Sbjct: 236 PSEVLIIADESADAVMVASDILAQSEHDPNSVSILVTGSDTLAEAVKREVLVQAEQAARS 295

Query: 296 ETARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSP 355
              + +L  + +++   L QC+  SN++ PEHL I   +   ++D I +AGS+F+G++SP
Sbjct: 296 SIIKSSLENAAILIADSLEQCIGFSNKFAPEHLEIMVADPDFVLDRIKNAGSIFIGNYSP 355

Query: 356 ESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAER 415
              GDYASGTNHVLPT GY    S L +  F K  ++Q +SK G  +L  T+  LA  E 
Sbjct: 356 VPVGDYASGTNHVLPTSGYARVYSGLNINHFIKYSSIQRISKSGLESLKETVIALAEEEG 415

Query: 416 LTAHKNAVTLRV 427
           L AH +A+  R 
Sbjct: 416 LQAHADAIRTRF 427


>UniRef50_Q58851 Histidinol dehydrogenase n=16 Tax=Euryarchaeota RepID=HISX_METJA
          Length = 429

 Score =  569 bits (1468), Expect = e-161,   Method: Composition-based stats.
 Identities = 176/433 (40%), Positives = 250/433 (57%), Gaps = 9/433 (2%)

Query: 1   MSFNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDK 60
           M    II       +++ + ++    +  E I  TV +IL +VK +GDEAL+ Y+ KFD 
Sbjct: 1   MVTGMIIKKIKELTKEEEEKIINRNKANFEEILPTVMEILKDVKEKGDEALKYYTKKFDG 60

Query: 61  TTVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQ-PGVRCQQ 119
             +   KV+ EEI  A   +  ++ +A+  A +NI  FH  Q     D+  +  G+   Q
Sbjct: 61  VEIEDFKVTDEEIEEAYNSVDYKVVEAIERAKENIYFFHKKQMEQIKDLNVENNGIILGQ 120

Query: 120 VTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPI----ADEILYAAQL 175
           V R +  VG Y+PGG A   STVLM   PA +AGC+++ + SPP          L A  +
Sbjct: 121 VVRAIEKVGCYVPGGRAFYPSTVLMTTIPAKVAGCEEIYITSPPTKDGKGNPATLIAGDI 180

Query: 176 CGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAG 235
            GV  ++ VGG QAI ALA+GTE++PKVD I GPGN +VT AK+ V   +   AID  AG
Sbjct: 181 VGVSAIYKVGGVQAIGALAYGTETIPKVDIIVGPGNIYVTTAKKMVYGEV---AIDFLAG 237

Query: 236 PSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRA 295
           PSEVL+IAD  A  +FVA D ++QAEH P++  ++ T +   A  +   +  ++ +  R 
Sbjct: 238 PSEVLIIADETANAEFVALDFIAQAEHDPNASCVITTTSEKKAEEIKNKIFEEIEKAERK 297

Query: 296 ETARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSP 355
           E   +AL  S +++  DL +C+E SN+Y PEHL I T+N  E+++ I  AGSVFLG++SP
Sbjct: 298 EIILKALENSAILI-GDLEECIEFSNKYAPEHLEILTKNPEEVLNKIKHAGSVFLGEYSP 356

Query: 356 ESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAER 415
              GDYASGTNHVLPT  +    S L +  F K++T Q+L KE    +A  + TLA AE 
Sbjct: 357 VPVGDYASGTNHVLPTSQFARMSSGLNVETFLKKITYQKLDKESLKNIADIVITLAEAEG 416

Query: 416 LTAHKNAVTLRVN 428
           L  H  AV  R+ 
Sbjct: 417 LFGHAEAVRRRLK 429


>UniRef50_Q722Y3 Histidinol dehydrogenase n=20 Tax=Firmicutes RepID=HISX_LISMF
          Length = 427

 Score =  568 bits (1465), Expect = e-160,   Method: Composition-based stats.
 Identities = 171/421 (40%), Positives = 246/421 (58%), Gaps = 7/421 (1%)

Query: 15  EQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIA 74
           E   +L +    + S  +   V  I++ VK  GD+AL ++++KFD   +T L+V A +I 
Sbjct: 10  ELLNELKIETDTNTSIQVETEVKTIIEKVKTAGDQALFDFTSKFDGVGLTELRVPAADIQ 69

Query: 75  AASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGG 134
           AAS ++      A+  A  NIE+FH+ QK        + GV   Q+ RP+ +VG+Y+PGG
Sbjct: 70  AASAKIEPAFLDALQQAKVNIESFHSKQKQHAFLDSEKDGVIRGQLIRPLETVGVYVPGG 129

Query: 135 SAPLFSTVLMLATPASIAGCKKVVLCSPP---PIADEILYAAQLCGVQDVFNVGGAQAIA 191
           +A   S+VLM   PA IAG K++V+ +PP    I   +L +AQL GV +++ VGGA  IA
Sbjct: 130 TAAYPSSVLMNVLPAKIAGVKRIVMITPPGENGINPYVLASAQLAGVDEIYQVGGAHGIA 189

Query: 192 ALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDF 251
           ALA GTES+PKVDKI GPGN +V  AKR+V   +D   IDM AGPSE++V+AD  A P F
Sbjct: 190 ALAHGTESIPKVDKIVGPGNIYVATAKREVFGLVD---IDMIAGPSEIVVLADENANPAF 246

Query: 252 VASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALN-ASRLIVT 310
           +A+DLLSQAEH   ++ IL+T +  +A      +++QL  LPR   A++++    ++I+ 
Sbjct: 247 IAADLLSQAEHDILARAILITTSKKIAEETQNEIDKQLENLPRKAIAQKSIETRGKIIIA 306

Query: 311 KDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLP 370
               +  +I N+  PEHL +Q  N    +  I +AGS+FLG ++ E  GDY +G NHVLP
Sbjct: 307 ATTQEMFDIMNEIAPEHLEVQLENPMNYLYQIKNAGSIFLGSYASEPLGDYFAGPNHVLP 366

Query: 371 TYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNAL 430
           T G     S LG+ DF KR      +KE  +     I  LA  E L AH  A+ +R    
Sbjct: 367 TSGTAKFFSPLGVEDFTKRSAFISYTKEALAKEKDAIVLLAKKEGLDAHAKAIQIRFEEE 426

Query: 431 K 431
            
Sbjct: 427 N 427


>UniRef50_A8RCE7 Putative uncharacterized protein n=1 Tax=Eubacterium dolichum DSM
           3991 RepID=A8RCE7_9FIRM
          Length = 427

 Score =  567 bits (1462), Expect = e-160,   Method: Composition-based stats.
 Identities = 177/429 (41%), Positives = 255/429 (59%), Gaps = 10/429 (2%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
               ++       Q +  +    +  + ++   V+ IL++V+  GDEA+  Y+ +FD   
Sbjct: 1   MLKQLNIEQID--QLQSYIEERRVVMNPALIGRVSAILEDVRMHGDEAVLRYTKQFDGME 58

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
           +  L+VS+EE+ A ++  + E +++M  A +NI  +H AQ      +E + G+   Q   
Sbjct: 59  LNKLRVSSEELNAQADLCTPEFRRSMQQAKENILFYHQAQISKGYRLEKEMGIYLGQRVL 118

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGV 178
           P+ SVG+Y+PGGSA   S+VLM A PA +AG K++V+ +PP     I   I  AA+L G+
Sbjct: 119 PLDSVGIYVPGGSAQYPSSVLMNALPARLAGVKRIVMLTPPSKEGSIHTNIALAAKLVGI 178

Query: 179 QDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSE 238
            +V+ VGGAQ IAALA+GT+S+ KVDKI GPGN +V  AK+ V   +D   IDM AGPSE
Sbjct: 179 DEVYKVGGAQGIAALAYGTQSIAKVDKIVGPGNVYVACAKKLVFGDVD---IDMIAGPSE 235

Query: 239 VLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETA 298
           +LVI D GA P ++A+DLLSQAEH P +  +LL  + +M   V + +++Q   LPR +  
Sbjct: 236 ILVIGDEGANPKWIAADLLSQAEHDPQASAVLLAVSQNMVDAVKQELQKQTRCLPRQKII 295

Query: 299 RQALNASRL-IVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPES 357
            ++L    L +V + L QCV+ISNQ  PEHL +      EL+  +  AGSVFLG  + ES
Sbjct: 296 HESLENYGLALVCESLQQCVDISNQIAPEHLELMVDKPEELLPLVRHAGSVFLGYATCES 355

Query: 358 AGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLT 417
            GDY  GTNHVLPT G     + LG+  F K+ +    S E   A   +I TLA AE+L 
Sbjct: 356 VGDYFGGTNHVLPTGGTARFFNPLGVDSFVKKSSYLHYSIEALQAYGDSIITLAEAEQLQ 415

Query: 418 AHKNAVTLR 426
           AH NAV +R
Sbjct: 416 AHANAVKVR 424


>UniRef50_Q9C5U8 Histidinol dehydrogenase, chloroplastic n=34 Tax=cellular organisms
           RepID=HISX_ARATH
          Length = 466

 Score =  566 bits (1459), Expect = e-160,   Method: Composition-based stats.
 Identities = 209/435 (48%), Positives = 274/435 (62%), Gaps = 8/435 (1%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
                 +  ++ Q   L  RP I  S SI  TVN I+D V++ GD A++EY+ +FDK  +
Sbjct: 32  MKSYRLSELSSSQVDSLKSRPRIDFS-SIFATVNPIIDAVRSNGDNAVKEYTERFDKVQL 90

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRP 123
             +     E+  +   L   +K+A  VA  NI  FH AQK     VE   GVRC++V+R 
Sbjct: 91  NKVVEDMSEL--SVPELDSNVKEAFDVAYDNIYAFHLAQKSTEKSVENMKGVRCKRVSRS 148

Query: 124 VASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQ 179
           + SVGLY+PGG+A L ST LMLA PA IAGCK VVL +PP     I  E+LY A+  GV 
Sbjct: 149 IGSVGLYVPGGTAVLPSTALMLAIPAQIAGCKTVVLATPPSKDGSICKEVLYCAKRAGVT 208

Query: 180 DVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEV 239
            +   GGAQAIAA+A+GT+S PKV+KIFGPGN +VT AK  +       +IDMPAGPSEV
Sbjct: 209 HILKAGGAQAIAAMAWGTDSCPKVEKIFGPGNQYVTAAKMILQNSEAMVSIDMPAGPSEV 268

Query: 240 LVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADM-ARRVAEAVERQLAELPRAETA 298
           LVIAD  A+P ++A+DLLSQAEHGPDSQV+L+     +    + E + +Q   LPR E A
Sbjct: 269 LVIADEHASPVYIAADLLSQAEHGPDSQVVLVVVGDSVDLNAIEEEIAKQCKSLPRGEFA 328

Query: 299 RQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESA 358
            +AL+ S  +  +D+ + +  SN Y PEHLII  ++A +    I +AGSVF+G W+PES 
Sbjct: 329 SKALSHSFTVFARDMIEAISFSNLYAPEHLIINVKDAEKWEGLIENAGSVFIGPWTPESV 388

Query: 359 GDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTA 418
           GDYASGTNHVLPTYGY    S + L  F K MTVQ L++EG   L   + T+A  E L A
Sbjct: 389 GDYASGTNHVLPTYGYARMYSGVSLDSFLKFMTVQSLTEEGLRNLGPYVATMAEIEGLDA 448

Query: 419 HKNAVTLRVNALKEQ 433
           HK AVTLR+  ++ +
Sbjct: 449 HKRAVTLRLKDIEAK 463


>UniRef50_Q02136 Histidinol dehydrogenase n=9 Tax=Bacteria RepID=HISX_LACLA
          Length = 431

 Score =  565 bits (1456), Expect = e-159,   Method: Composition-based stats.
 Identities = 164/435 (37%), Positives = 250/435 (57%), Gaps = 11/435 (2%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDK-- 60
               ID+     E+  +         S+ + +TV  I+ +++  GD AL  Y+ KFD   
Sbjct: 1   MLKQIDYQGKL-EEIAEKFQGRKTEVSKEVNKTVQQIVADIQKNGDTALFNYAKKFDGYD 59

Query: 61  TTVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQV 120
              + L V+  E  A  E++ ++  + +      IE FH  Q     ++  + GV   Q+
Sbjct: 60  VNTSNLLVTRMEREAGLEQIDEDYFRILRRTKSQIEEFHKHQLGNSWNIFKENGVIMGQI 119

Query: 121 TRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSP----PPIADEILYAAQLC 176
            RP+  V LY+PGG+A   STV+M A PA +AG K++++ +P      +   IL AA++C
Sbjct: 120 ARPLERVALYVPGGTAAYPSTVIMNAVPALLAGVKEIIMITPVKADGKVNPNILAAAEVC 179

Query: 177 GVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGP 236
           G++ ++ VGGAQ +AA+A+GTES+PKVDKI GPGN FV  AK+     +D   IDM AGP
Sbjct: 180 GIETIYKVGGAQGVAAVAYGTESIPKVDKIVGPGNIFVATAKKICYGVVD---IDMIAGP 236

Query: 237 SEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAE 296
           SEVLVIAD  A P ++A+DL++QAEH   +  IL+T +  + ++V E + RQ+  L R E
Sbjct: 237 SEVLVIADKTAKPKYIAADLMAQAEHDKLASAILVTTSEKLVQQVDEELNRQVQNLERRE 296

Query: 297 TARQAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSP 355
               ++ N    IV K++    ++SNQ  PEHL + T      +  I +AGS+F+G+++P
Sbjct: 297 IIESSIRNYGGAIVVKNIDDAFDVSNQLAPEHLEVLTSEPLTQLPKIKNAGSIFIGEYTP 356

Query: 356 ESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAER 415
           E  GDY SG+NHVLPT G     S LG+ +F K +T     KE  +     +ET A +E 
Sbjct: 357 EPLGDYMSGSNHVLPTGGTAKFYSGLGVYNFIKYLTYSYYPKEVLADFKEDVETFAKSEG 416

Query: 416 LTAHKNAVTLRVNAL 430
           LTAH N++++R + +
Sbjct: 417 LTAHANSISVRFDEM 431


>UniRef50_Q30TA4 Histidinol dehydrogenase n=16 Tax=Epsilonproteobacteria
           RepID=HISX_SULDN
          Length = 430

 Score =  564 bits (1455), Expect = e-159,   Method: Composition-based stats.
 Identities = 164/432 (37%), Positives = 249/432 (57%), Gaps = 11/432 (2%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
                  NS    + ++LL R  +  +  ++ TV  I+D +K+  ++AL+E+  KFDK T
Sbjct: 1   MIFTTSKNSSFKAEFKELLERGKMDIAH-VSATVGTIIDEIKSNKNQALKEHITKFDKWT 59

Query: 63  V---TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQ 119
                 LK+S E ++ A E L   LK A+ ++   I+ +H  QK      +   G    Q
Sbjct: 60  PVSDEDLKISTESMSRAYENLDKALKAALHLSYDRIKAYHEKQKPRSWFDDEPNGTILGQ 119

Query: 120 VTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLC 176
              PV S GLYIPGG A   S++LM   PA +AG + +V+C+P P     + +L A  LC
Sbjct: 120 RVTPVDSAGLYIPGGKAAYPSSLLMNVIPAQVAGVQNIVVCTPTPENEPNELLLAACHLC 179

Query: 177 GVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGP 236
           GV +V+ VGGA AIAA+A+GTE++PKVD I GPGN FV  AK+ V   ++   IDM AGP
Sbjct: 180 GVSEVYKVGGASAIAAMAYGTETIPKVDVITGPGNIFVATAKKMVFGDVN---IDMIAGP 236

Query: 237 SEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAE 296
           SE+ ++AD  A P  +A D+LSQAEH   +  IL+TP+  +A  +   +E  L  LPR +
Sbjct: 237 SEIGILADDSANPSHMAVDMLSQAEHDEMASSILITPSQKLADAIKAEIENWLKILPRQK 296

Query: 297 TARQALNA-SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSP 355
            AR+++     +IVT D+ + +++ N+  PEHL + T +  EL+  I  AG++FLG  +P
Sbjct: 297 IARESIEKRGAIIVTSDMQEAIDLMNEIAPEHLEVATLSPFELLPLIKHAGAIFLGHNTP 356

Query: 356 ESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAER 415
           E+ GDY +G NH LPT G     S LG+ +F K+ ++   S +  + +      +A  E 
Sbjct: 357 EAVGDYMAGPNHTLPTGGTAKFFSPLGVENFMKKTSIISFSAKAINEIGEECALIAKIEG 416

Query: 416 LTAHKNAVTLRV 427
           LTAH+ ++ +R+
Sbjct: 417 LTAHEQSIRVRL 428


>UniRef50_D1CF70 Histidinol dehydrogenase n=1 Tax=Thermobaculum terrenum ATCC
           BAA-798 RepID=D1CF70_THET1
          Length = 433

 Score =  564 bits (1454), Expect = e-159,   Method: Composition-based stats.
 Identities = 186/427 (43%), Positives = 273/427 (63%), Gaps = 9/427 (2%)

Query: 7   IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTAL 66
           I     + E++R+L  R   + S  +T  V  I+++V+ +GDE++REY+ +FD   + +L
Sbjct: 10  IRLADLSPEERRRLTHRSG-AISMDVTSVVRQIVEDVRQKGDESVREYTERFDGVKLDSL 68

Query: 67  KVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVAS 126
           +V   EI  A +R+   L +AM++A  NI  FH+AQ  P   VET PGV+  +V RP+  
Sbjct: 69  EVPRVEIETALDRIDQHLAEAMSIAASNIRAFHSAQIHPEPVVETSPGVKVWRVWRPIER 128

Query: 127 VGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQDVF 182
           VG+Y+PGG A   STVLM A PAS+AGC ++VLC+PP     + +  L AA L GV  VF
Sbjct: 129 VGVYVPGGGARYPSTVLMHAVPASVAGCSEIVLCTPPGPDGKVPEATLAAAALSGVTRVF 188

Query: 183 NVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVI 242
           ++GGAQAIAA+A+GT+++P V KIFGPGN +VT AK  V   +D   ID PAGPSE+++I
Sbjct: 189 SIGGAQAIAAMAYGTQTIPPVQKIFGPGNVYVTAAKMLVFGDVD---IDKPAGPSELVII 245

Query: 243 ADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL 302
           AD  A P   A+DL++Q+EH PD+  +L+T +  +A  V   + RQL +LP  +    + 
Sbjct: 246 ADDTADPRETAADLIAQSEHAPDNASVLVTTSESLAEAVLSELTRQLEDLPNRDRVISSF 305

Query: 303 -NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDY 361
            +   +++ +DLAQ V   N+Y PEHL I T + RE+++ I +AGS+FLG +SP  AGDY
Sbjct: 306 RSNGFILLVEDLAQAVGFVNEYAPEHLQIVTVSPREILEGINNAGSIFLGRYSPVPAGDY 365

Query: 362 ASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKN 421
           A G+NHVLPT G   T   L   +F K + VQEL++EG  ++++ +  +A AE L  H  
Sbjct: 366 AVGSNHVLPTSGSARTFGPLSTEEFGKWVQVQELTQEGLRSISNAVTAMARAENLEGHAR 425

Query: 422 AVTLRVN 428
           A+ +R +
Sbjct: 426 AIEVRFS 432


>UniRef50_Q8YSM8 Histidinol dehydrogenase 1 n=16 Tax=Bacteria RepID=HISX1_ANASP
          Length = 431

 Score =  561 bits (1447), Expect = e-158,   Method: Composition-based stats.
 Identities = 174/431 (40%), Positives = 256/431 (59%), Gaps = 7/431 (1%)

Query: 6   IIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA 65
           ++         + Q L+     A+  ++ TV DIL +VKARGD A++EY+++FD     +
Sbjct: 3   VLKTTDKEFSPRFQSLVSDRREATVDVSGTVRDILAHVKARGDAAVQEYTSRFDHYRPHS 62

Query: 66  LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVA 125
             +SA  IA  + + SDE+K A+ +A + I +FH  Q    +      GV+       ++
Sbjct: 63  HHLSAAFIAEQAAKCSDEVKAALELAAERISSFHQKQLPQDIGYTDTAGVKLGLNWVALS 122

Query: 126 SVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCGVQDVF 182
            VG+Y+PGG A   S+VLM A PA IAG +++V+  P P   I   +L AAQ+ GV +++
Sbjct: 123 QVGIYVPGGRASYPSSVLMNALPAKIAGVERIVMTVPMPHGEINPAVLAAAQVAGVTEIY 182

Query: 183 NVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVI 242
           ++GGAQA+ ALA+GTE++  VDKI GPGNA+V EAKRQV   +    ID  AGPSE+LV+
Sbjct: 183 SIGGAQAVGALAYGTETITPVDKIVGPGNAYVAEAKRQVFGTV---GIDSIAGPSEILVV 239

Query: 243 ADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL 302
           AD    P+++A DLLSQAEH P +Q IL+T +   A++V  AVE+ L  LP  + A  + 
Sbjct: 240 ADRQNNPEWIAWDLLSQAEHDPSAQSILITDSESFAQQVIAAVEQILTTLPSQKVASSSW 299

Query: 303 -NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDY 361
            N   +I+ +DLA+ + + NQ  PEH+ +   N + L   I  AGS+FLG ++PE+ GDY
Sbjct: 300 QNHGAVIIVRDLAESIPLLNQLAPEHVELCVDNPQLLASQIKCAGSLFLGRYTPEAIGDY 359

Query: 362 ASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKN 421
             G NHVLPT       S L + DF KR+T  E ++     +  +  TLA  E L AH  
Sbjct: 360 LGGPNHVLPTSRSARFASGLSVYDFLKRITYLECNQAALQKIGQSAVTLAETEGLPAHAG 419

Query: 422 AVTLRVNALKE 432
           +V +R+  LK+
Sbjct: 420 SVAVRLQGLKD 430


>UniRef50_C0GFZ9 Histidinol dehydrogenase n=1 Tax=Dethiobacter alkaliphilus AHT 1
           RepID=C0GFZ9_9FIRM
          Length = 432

 Score =  560 bits (1445), Expect = e-158,   Method: Composition-based stats.
 Identities = 183/431 (42%), Positives = 244/431 (56%), Gaps = 8/431 (1%)

Query: 9   WNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKV 68
                    R+   R         T+ V DIL  V  RGDEA+ EY+ KFD   +  L V
Sbjct: 2   LREFDGRTFRETFTRAGFDDYPEATQAVRDILAEVNQRGDEAVLEYTRKFDGVELETLLV 61

Query: 69  SAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVG 128
           S EE AAA E +  E++Q++  A +NI  FH  Q           GV   Q    V   G
Sbjct: 62  SEEEFAAAEEAVDPEVRQSLVEAAENIRDFHRRQVQNSWLEHQADGVALGQRVTAVEKAG 121

Query: 129 LYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQDVFNV 184
            Y+PGG A   S+VLM   PA +AG +KVVL +PP     I    L AA++ G   V+  
Sbjct: 122 AYVPGGGAAYPSSVLMTVIPARVAGVEKVVLVTPPQAGGEINPYTLVAAKIAGADAVYKC 181

Query: 185 GGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIAD 244
           GGAQA+AALA+GTE+VPKVDKI GPGN +VT AKR+VS  +    IDM AGPSEVLV+AD
Sbjct: 182 GGAQAVAALAYGTETVPKVDKIVGPGNLYVTLAKREVSGMV---GIDMLAGPSEVLVVAD 238

Query: 245 SGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-N 303
           + A  DFVA+DLLSQAEH   +    +T +A +A  + + ++RQ A+L R + AR++L  
Sbjct: 239 ASARADFVAADLLSQAEHDVMAASYCVTTSARLALDLQKELKRQCAQLERCDVARESLQQ 298

Query: 304 ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYAS 363
              L++   L + +EI N+  PEHL +Q     E +  + +AG+VF+G ++PE  GDY +
Sbjct: 299 QGALVIVDSLDEALEIVNELAPEHLELQLSEPWEALGKVKNAGAVFVGPYTPEPVGDYWA 358

Query: 364 GTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAV 423
           G NHVLPT G     S L + DF K+ +V   S +     A  IE LA  E LTAH  AV
Sbjct: 359 GPNHVLPTAGAGRFSSVLSVDDFVKKTSVIYYSPQALLKSAQKIEGLARVEGLTAHGQAV 418

Query: 424 TLRVNALKEQA 434
            +R   L+E+ 
Sbjct: 419 KIRREYLEEKG 429


>UniRef50_Q46J19 Histidinol dehydrogenase n=60 Tax=Bacteria RepID=HISX_PROMT
          Length = 449

 Score =  559 bits (1441), Expect = e-158,   Method: Composition-based stats.
 Identities = 164/433 (37%), Positives = 252/433 (58%), Gaps = 10/433 (2%)

Query: 4   NTIIDWNSCTAE--QQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKT 61
            TI   NS      + R++  R + +  +   + V+DIL NV+ RGDEAL EY+++FD  
Sbjct: 18  LTIKTANSIDQAQFELRKITERTSGTVQDEAIKVVDDILKNVRERGDEALTEYTSRFDGF 77

Query: 62  TVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVT 121
                +VS++ I  A E    EL+ ++ +A K IE FH+ Q    +      G    +  
Sbjct: 78  LTEKFQVSSDLILKAWEETPRELQDSLLLAKKRIEKFHSLQVPKNITYTGPNGETLGRRW 137

Query: 122 RPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCG 177
            PV   G+Y+PGG A   STVLM A PA +AG  ++++ SP      I   +L AA + G
Sbjct: 138 SPVEKAGIYVPGGRAAYPSTVLMNAIPAYVAGVNQIIMVSPANSQGEINQTVLAAAHITG 197

Query: 178 VQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPS 237
           +  +F +GGAQAI ALA GTES+PKVD I GPGN +VT AK++V  ++    ID  AGPS
Sbjct: 198 INKIFRLGGAQAICALASGTESIPKVDVITGPGNIYVTLAKKKVYGKV---GIDSLAGPS 254

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAET 297
           E+L+IAD  A  + VASD+L+Q+EH P +  IL+T    +A ++   + RQL   PR + 
Sbjct: 255 EILIIADQSAKLEHVASDMLAQSEHDPLASAILITTNTKLAEKLPAEINRQLINHPRLKI 314

Query: 298 ARQAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPE 356
            ++++ N   +++  DL  C ++S+ + PEHL +   + ++L +SI +AG++F+G WSPE
Sbjct: 315 CQESISNWGLIVLCDDLETCAQLSDTFAPEHLELLVEDPKKLSESINNAGAIFMGPWSPE 374

Query: 357 SAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERL 416
           + GDY  G NH LPT G      +LG+  F K  ++ + SKE F+   + +  LA +E L
Sbjct: 375 AIGDYLGGPNHTLPTSGTARFAGALGVETFMKNTSLIDFSKEAFNENKNAVVQLANSEGL 434

Query: 417 TAHKNAVTLRVNA 429
            +H  ++ +R + 
Sbjct: 435 HSHAESIRIRDSK 447


>UniRef50_C6Y3G2 Histidinol dehydrogenase n=6 Tax=cellular organisms
           RepID=C6Y3G2_PEDHD
          Length = 430

 Score =  559 bits (1441), Expect = e-158,   Method: Composition-based stats.
 Identities = 198/432 (45%), Positives = 277/432 (64%), Gaps = 6/432 (1%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
             I  +   T ++  ++ +R  +    +I   V  I++ VK  GD+AL +Y+  FD+  +
Sbjct: 1   MKIYSYKDLTKQEVEEICLR-QLEDDVNIQERVKSIVERVKMEGDKALFDYALSFDQIRL 59

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRP 123
             L +  +EI   +  +  E K A+  A +NI+TFH +Q L    VET PGV C + TR 
Sbjct: 60  EELFIDQQEIMTIAATIPAEAKAAIDTAYQNIKTFHASQLLQEDKVETMPGVTCWRETRA 119

Query: 124 VASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIAD----EILYAAQLCGVQ 179
           +  VGLYIPGG+A L ST LML  PA +AGCK++V+CSPP         + Y A L G++
Sbjct: 120 IERVGLYIPGGTAVLPSTFLMLGIPAVLAGCKEIVVCSPPQKDGKTNCYLAYVATLLGIE 179

Query: 180 DVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEV 239
            ++ VGGAQA+AA+A+GT SVPKVDK+FGPGN +VT+AK+ +       AIDMPAGPSEV
Sbjct: 180 RIYLVGGAQAVAAMAYGTASVPKVDKVFGPGNRYVTQAKQLIQGNT-MTAIDMPAGPSEV 238

Query: 240 LVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETAR 299
           LV+AD  A P ++ASDLL+QAEHG DSQ IL+  ++ +     E +  QL  LPRA  A 
Sbjct: 239 LVLADETAIPSYIASDLLAQAEHGIDSQTILVATSSKIIDETMEQLALQLQVLPRAAFAT 298

Query: 300 QALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAG 359
           +A+  S  ++  DL + ++ SN Y PEHLI+ T N   L+  I++AGSVFLG+ +PESAG
Sbjct: 299 KAIENSYSVLVNDLEEGMKFSNVYAPEHLILATDNCERLIPLISNAGSVFLGNLTPESAG 358

Query: 360 DYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAH 419
           DYASGTNH LPT GY    S + +  F K++T Q ++ +G   + +T+E LAAAE L AH
Sbjct: 359 DYASGTNHTLPTSGYARAYSGVSMDSFMKKITFQHITTQGLRHIGNTVEVLAAAEGLDAH 418

Query: 420 KNAVTLRVNALK 431
           KNAV++R+ +L 
Sbjct: 419 KNAVSIRLKSLD 430


>UniRef50_Q6FEC8 Histidinol dehydrogenase n=50 Tax=Bacteria RepID=HISX_ACIAD
          Length = 430

 Score =  557 bits (1435), Expect = e-157,   Method: Composition-based stats.
 Identities = 162/433 (37%), Positives = 246/433 (56%), Gaps = 10/433 (2%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKT- 61
               +     + +Q    L+         + +TV+ I+ +V+  GDE + + + +FD+  
Sbjct: 1   MMRRLSTQDQSFKQVFADLLAFETVNDPELLKTVDQIIADVRQYGDEHVLKLTQQFDRHP 60

Query: 62  --TVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQ 119
               + L+++ E++  A E L+ E+++A+ +A + I +FH AQK          G    Q
Sbjct: 61  AHQFSDLELTQEQLKTAFEALTAEIREALELAAERIRSFHQAQKQEGWSYVDALGNTLGQ 120

Query: 120 VTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLC 176
              P+  VG+Y+PGG A   S+VLM A PA +AG  ++++  P P   +   +L AA L 
Sbjct: 121 KVTPLDRVGIYVPGGLASYPSSVLMNAIPAHVAGVPEIIMVVPAPNGELNSLVLAAAYLA 180

Query: 177 GVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGP 236
           GV  +F +GGAQA+AALA+GT+++P VDKI GPGN FV  AKR V  ++    IDM AGP
Sbjct: 181 GVSRIFTIGGAQAVAALAYGTQTIPAVDKITGPGNRFVAAAKRAVFGQV---GIDMIAGP 237

Query: 237 SEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAE 296
           SE+LV A+      ++A DLLSQAEH   +Q I +TP   +   VA+A+E  LA LP+A+
Sbjct: 238 SEILVYAEGQNNAKWLAMDLLSQAEHDTVAQAIFITPDEALLDEVAQAIEEHLAALPKAD 297

Query: 297 TARQALNA-SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSP 355
            AR ++     L++ KD  + +E+ NQ  PEHL +    +  +   I  AG++F+G ++P
Sbjct: 298 IARTSIANRGALVLVKDRDEAIELINQVAPEHLELCLDESEAMSQKIRHAGAIFMGRYTP 357

Query: 356 ESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAER 415
           E+ GDY +G NHVLPT G     S LG+ DFQKR ++   S+EG  +LA   + LA  E 
Sbjct: 358 EAIGDYCAGPNHVLPTSGTARFSSPLGVYDFQKRSSLIMCSQEGVKSLAKAADVLAQQEN 417

Query: 416 LTAHKNAVTLRVN 428
           L AH  +   R  
Sbjct: 418 LDAHARSARYRYQ 430


>UniRef50_B0TY46 Histidinol dehydrogenase n=2 Tax=Francisella philomiragia
           RepID=B0TY46_FRAP2
          Length = 432

 Score =  557 bits (1435), Expect = e-157,   Method: Composition-based stats.
 Identities = 191/432 (44%), Positives = 276/432 (63%), Gaps = 4/432 (0%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              I +W   +  +Q +LL RP  +   S+   V +IL+ VK  GD+AL E++++FD   
Sbjct: 1   MIEIYNWQELSLVKQAELLSRPVSANKASLVAGVRNILNAVKQNGDKALLEFTSRFDGVD 60

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
           +  ++VSA EI  A   +S +  + +  ++  I  +H   K      +T  GV C+++ +
Sbjct: 61  LDNIEVSAHEIKEAYSLVSQDDIELVKNSIARISNYHEVMKPKTTVCDTNDGVVCKKIYK 120

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSP----PPIADEILYAAQLCGV 178
           P+  VGLY+PGGSAPL ST++MLA PA IAGCK++ + +P      I   IL AA +C V
Sbjct: 121 PIEKVGLYVPGGSAPLVSTLIMLAAPAQIAGCKEIYVTTPCDKEGNIHPLILIAADICKV 180

Query: 179 QDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSE 238
             ++ +GGAQAIAALA+GTE+V KV+KI+GPGN++VTEAK+QVS    GAAID+PAGPSE
Sbjct: 181 SKIYKLGGAQAIAALAYGTETVTKVNKIYGPGNSWVTEAKQQVSNDSQGAAIDLPAGPSE 240

Query: 239 VLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETA 298
           VLV+AD  A   FVA+DLL+QAEHG DSQ +L+T +  +A +V + V +Q +   R    
Sbjct: 241 VLVVADEVADARFVAADLLAQAEHGTDSQALLITTSQILADKVRDEVSKQTSTAQRKAII 300

Query: 299 RQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESA 358
            +AL  S +IV   L+Q + I+N+Y  EHLI+    A   +DSI +AG+VF+G W+ E+ 
Sbjct: 301 EKALENSAIIVVDTLSQAINIANEYASEHLILNIETADNYIDSIENAGAVFVGPWAAEAL 360

Query: 359 GDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTA 418
           GDY +G+NHVLPTYGY    S L   DF K +++Q +SK+G   +      LA  E L A
Sbjct: 361 GDYITGSNHVLPTYGYAKAYSGLATIDFMKAISIQNVSKQGIKNIGQIAMRLADIEGLKA 420

Query: 419 HKNAVTLRVNAL 430
           H+NA+ +R+ +L
Sbjct: 421 HENAIAIRLESL 432


>UniRef50_Q4ZNV9 Histidinol dehydrogenase n=116 Tax=Bacteria RepID=HISX_PSEU2
          Length = 448

 Score =  554 bits (1429), Expect = e-156,   Method: Composition-based stats.
 Identities = 165/428 (38%), Positives = 240/428 (56%), Gaps = 10/428 (2%)

Query: 7   IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDK---TTV 63
           +D       +    L+     + +S+ + V DI+  V+ RGD AL E++ KFD     ++
Sbjct: 10  LDAADPDFARHLDHLLSWESVSDDSVNQRVLDIIKAVRERGDAALVEFTQKFDGLQVASM 69

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRP 123
             L +  E +  A  R++   ++A+  A + + ++H  QK          G    Q   P
Sbjct: 70  ADLILPRERLELALTRITPGQREALEKAAERVRSYHEKQKQDSWSYTEADGTVLGQKVTP 129

Query: 124 VASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCGVQD 180
           +   GLY+PGG A   S+VLM A PA +AG  +VV+  P P   I + +L AA + GV  
Sbjct: 130 LDRAGLYVPGGKASYPSSVLMNAIPAKVAGVTEVVMVVPTPRGEINELVLAAACIAGVDR 189

Query: 181 VFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVL 240
           VF +GGAQA+AALA+GTESVPKVDK+ GPGN +V  AKR V  ++    IDM AGPSE+L
Sbjct: 190 VFTIGGAQAVAALAYGTESVPKVDKVVGPGNIYVATAKRHVFGQV---GIDMIAGPSEIL 246

Query: 241 VIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQ 300
           V+ D    PD++A DL SQAEH  D+Q IL++P A+   +VA ++ R L  + RA     
Sbjct: 247 VVCDGQTDPDWIAMDLFSQAEHDEDAQAILVSPDAEFLDKVAASITRLLPTMERAAIVET 306

Query: 301 ALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAG 359
           ++N    LI   D+AQ +E++N+  PEHL +   +    +  I  AG++F+G  + E+ G
Sbjct: 307 SINGRGALIKVADMAQAIEVANRIAPEHLELSVADPEAWLPQIRHAGAIFMGRHTSEALG 366

Query: 360 DYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAH 419
           DY +G NHVLPT G     S LG+ DFQKR ++   S +G S L  T   LA  E L+ H
Sbjct: 367 DYCAGPNHVLPTSGTARFSSPLGVYDFQKRSSIIYCSPQGASELGKTASVLARGESLSGH 426

Query: 420 KNAVTLRV 427
             +   R+
Sbjct: 427 ARSAEYRI 434


>UniRef50_P59399 Histidinol dehydrogenase n=14 Tax=Bacteria RepID=HISX_LACPL
          Length = 428

 Score =  553 bits (1426), Expect = e-156,   Method: Composition-based stats.
 Identities = 175/429 (40%), Positives = 250/429 (58%), Gaps = 9/429 (2%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
             II+     A  +R +  +        +   V +I+ NV   GD A+++Y  +FDK T+
Sbjct: 1   MKIIN--EDLASLKRLVQTKTQQLTDLKVESAVREIIANVIKNGDAAVKDYETQFDKVTL 58

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRP 123
           T  K+S   I  A   L  ++K A+ +A +NI +FH  +K        QPGV   Q   P
Sbjct: 59  TDFKLSQTVIDDAYNNLDPQVKDALLLAKRNITSFHEKEKATGFIDAEQPGVLRGQKLMP 118

Query: 124 VASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP---PIADEILYAAQLCGVQD 180
           +  VGLY+PGG+A   ST+LM A PA IAG  +V++ +PP    I   +L AA++ GV  
Sbjct: 119 LNRVGLYVPGGTAAYPSTLLMSALPAKIAGVNEVIMVTPPQVDGINPAVLAAAKIAGVDA 178

Query: 181 VFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVL 240
           ++ VGGAQAIAALA+GTES+P VDKI GPGN FV  AK+QV  ++   AIDM AGPSE+ 
Sbjct: 179 IYQVGGAQAIAALAYGTESIPAVDKIIGPGNIFVATAKKQVFGQV---AIDMVAGPSEIG 235

Query: 241 VIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQ 300
           ++AD  A P  +A+DLLSQAEH   ++ IL+T +AD+A+ V++ V  QL  LPR   A  
Sbjct: 236 ILADDSADPRQLAADLLSQAEHDRRARPILITDSADLAQAVSDNVTSQLKVLPREAIATD 295

Query: 301 AL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAG 359
           A+     + V   + +  ++ N   PEHL +Q +N  + ++ I +AGSVFLG ++ E  G
Sbjct: 296 AVNEKGFIAVVAKIEEMFDLMNTVAPEHLEVQLKNPTQYLNLIKNAGSVFLGRYASEPLG 355

Query: 360 DYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAH 419
           DY +G NH+LPT G     S LG+ DF KR +  + +K+  +  A  I TLA  E L  H
Sbjct: 356 DYVAGPNHILPTSGTARFSSPLGVYDFVKRTSFIQYTKDALAKEAPAITTLARVEGLEGH 415

Query: 420 KNAVTLRVN 428
             A+  R +
Sbjct: 416 ARAIESRFD 424


>UniRef50_D0RRH1 Histidinol dehydrogenase n=1 Tax=alpha proteobacterium HIMB114
           RepID=D0RRH1_9RICK
          Length = 429

 Score =  552 bits (1424), Expect = e-156,   Method: Composition-based stats.
 Identities = 159/431 (36%), Positives = 247/431 (57%), Gaps = 9/431 (2%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT- 62
             I++  +   ++   L++      S +  + V  I+ ++K  GD AL +Y+ +FDK   
Sbjct: 1   MKILNTKNKLFKKNFDLVLSSKRIQSNNSQKIVKKIISDIKKNGDLALIKYTKRFDKVNF 60

Query: 63  -VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVT 121
             + +K+  + I+   ++L   +K+++ +A   I  FH  Q       + + G +     
Sbjct: 61  GPSKIKLDDKLISKKIKKLDINIKKSIDLAFNRITKFHKKQVHKGFKFKDKLGNQLGYKI 120

Query: 122 RPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCGV 178
            P+  VG+Y+PGG+A   ST+LM + PA +AG K +    P P   I   +LYAA+ C +
Sbjct: 121 LPLDKVGVYVPGGTASYPSTLLMNSIPAMVAGVKNIYCVMPTPKDEINAGVLYAAKKCKI 180

Query: 179 QDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSE 238
           + +F +GGAQA+AAL +GT++VPKVDKI GPGN FV  AK++V   +    IDM AGPSE
Sbjct: 181 KSIFRIGGAQAVAALTYGTKNVPKVDKIVGPGNIFVATAKKEVFGTV---GIDMVAGPSE 237

Query: 239 VLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETA 298
           + VIAD     D+ A DLLSQAEH   SQ ILLT +   A++V+  V++ L  LPR + A
Sbjct: 238 ITVIADDRNRADWTAVDLLSQAEHDVLSQSILLTTSEKFAKQVSLEVKKILKTLPRKKIA 297

Query: 299 RQALNA-SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPES 357
            +++     ++V K+  + V+ +N   PEHL I+ + + +L   I +AGS+FLG++SPE+
Sbjct: 298 SKSIKNYGCIVVCKNKKELVDYANIIAPEHLEIKIKGSEKLEKQIKNAGSIFLGEFSPEA 357

Query: 358 AGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLT 417
            GDY +G NHVLPT G     S L + DF KR ++ + +K G   +      LA  E L 
Sbjct: 358 IGDYLAGPNHVLPTSGSARFASGLSVNDFLKRTSLIKCTKRGIEKIGQMAINLANYEGLH 417

Query: 418 AHKNAVTLRVN 428
           AH  +V+ R+ 
Sbjct: 418 AHALSVSKRIK 428


>UniRef50_D0JBA3 Histidinol dehydrogenase n=2 Tax=Blattabacterium RepID=D0JBA3_BLASB
          Length = 435

 Score =  552 bits (1424), Expect = e-156,   Method: Composition-based stats.
 Identities = 185/430 (43%), Positives = 270/430 (62%), Gaps = 7/430 (1%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
           N I  +   T +  + +L R +   S  +T  V  I++NVK  GD A++ Y+ K+D   +
Sbjct: 3   NMIQVYIHPTYKTCQSILNRSSEKISH-LTDLVLSIINNVKNNGDTAVKTYTRKYDHVDI 61

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRP 123
             ++V+ E+   A+ ++S  L++++ +A KNIE FH  Q      +E   GV C + + P
Sbjct: 62  KHIQVTEEDFQKANMKVSSHLRKSIEIAYKNIECFHKKQIHEESKIEVSTGVFCWRKSVP 121

Query: 124 VASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQ 179
           +  VG YIPGGSAPL STVLML  P  +AGCK +VLCSPP     I   +LY A+  G+ 
Sbjct: 122 IEKVGFYIPGGSAPLLSTVLMLGVPGKLAGCKNIVLCSPPNKNGEIHPSVLYTAKYVGIN 181

Query: 180 DVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEV 239
            ++ VGG QAIAA+A+GTES+P V KIFGPGN +VT AK+ VSQ+    +IDMPAGPSEV
Sbjct: 182 QIYKVGGVQAIAAMAYGTESIPSVYKIFGPGNCYVTIAKQIVSQK-GIVSIDMPAGPSEV 240

Query: 240 LVIADSGATPDFVASDLLSQAEHGPDSQVILLT-PAADMARRVAEAVERQLAELPRAETA 298
           +++AD  A P +VASDLLSQ+EH P+S ++L+T        +V E +++Q   L + +  
Sbjct: 241 VIMADDEANPKYVASDLLSQSEHDPESYILLVTINNKSWIEKVKEELKKQFYHLSKKKIL 300

Query: 299 RQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESA 358
            +    S+++V   L +C+   NQ  PEHLII   N     + + +AGSVFLG++SP S 
Sbjct: 301 LKIFRKSKIVVFSSLEECMNFINQVAPEHLIINCNNVSYWSEKVINAGSVFLGNYSPVSI 360

Query: 359 GDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTA 418
           GDYASGTNHVLPTYGY  + S + +  F K++T Q++SK+G   L+  +  L++ E L A
Sbjct: 361 GDYASGTNHVLPTYGYAKSYSGVSVDSFVKKITFQKISKKGLQNLSECVNVLSSEEGLIA 420

Query: 419 HKNAVTLRVN 428
           HK ++ +R+ 
Sbjct: 421 HKKSIDIRLK 430


>UniRef50_A9NV24 Histidinol dehydrogenase n=2 Tax=Spermatophyta RepID=A9NV24_PICSI
          Length = 491

 Score =  552 bits (1423), Expect = e-156,   Method: Composition-based stats.
 Identities = 197/443 (44%), Positives = 265/443 (59%), Gaps = 15/443 (3%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
                     + Q   L  RP I  S S+   V  I+++V+ RGD A+ +Y+ KFD   +
Sbjct: 50  MKTYRLADLHSTQIDHLKARPRIDFS-SMFGVVGPIIEDVRKRGDVAVIDYTTKFDGVNL 108

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQP-------GVR 116
             +     ++     +L   ++ A  VA  NI  FH AQ+ P   VE          GV 
Sbjct: 109 DKVVECVADLPD--PKLDSAVQAAFDVAYDNIRAFHAAQRNPERVVENMKVGSVLGRGVM 166

Query: 117 CQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYA 172
           C++V R + SVGLY+PGG+A L ST LMLA PA +AGC+ ++L SPP     I  E+LY 
Sbjct: 167 CKRVARSIDSVGLYVPGGTAVLPSTALMLAVPAQLAGCRIIILASPPRPDGSICKEVLYC 226

Query: 173 AQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDM 232
           A+  GV  +   GGAQAI+A+A+GT S PKV+KI GPGN +VT AK  +       +IDM
Sbjct: 227 AKKAGVTHILKAGGAQAISAMAWGTTSCPKVEKILGPGNQYVTAAKMILQNSEAMISIDM 286

Query: 233 PAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADM-ARRVAEAVERQLAE 291
           PAGPSEVLVIAD  A P ++A+DLLSQAEHGPDSQV+L+     +    +   +E+Q   
Sbjct: 287 PAGPSEVLVIADKHANPVYIAADLLSQAEHGPDSQVVLVLVGEGVNLDEIEMELEKQCKS 346

Query: 292 LPRAETARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLG 351
           LPR + A +AL  S  ++ ++ A+ +  SN Y PEHLII   +A + VD I +AGSVFLG
Sbjct: 347 LPRGQFAAKALTHSFTVLARNKAEAISFSNLYAPEHLIINVEDADQWVDYIENAGSVFLG 406

Query: 352 DWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLA 411
            WSPES GDYASGTNHVLPTYGY      + L  F K +TVQ L++EG  +L   +  +A
Sbjct: 407 RWSPESIGDYASGTNHVLPTYGYARMYGGVSLDSFMKYITVQSLTEEGLKSLGPHVVKMA 466

Query: 412 AAERLTAHKNAVTLRVNALKEQA 434
             E L AHK AVTLR+  ++ ++
Sbjct: 467 EVEGLEAHKRAVTLRLQDIETRS 489


>UniRef50_B9D1F9 Histidinol dehydrogenase n=2 Tax=Campylobacter RepID=B9D1F9_WOLRE
          Length = 431

 Score =  550 bits (1418), Expect = e-155,   Method: Composition-based stats.
 Identities = 159/434 (36%), Positives = 246/434 (56%), Gaps = 9/434 (2%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
              +  ++   +     L+  +     ++T  V+ IL++V+ARGDEAL E   KFD+   
Sbjct: 1   MKFLLTSNENFKDYFAALVNRSNGDMSAVTPAVSQILEDVRARGDEALFEQIEKFDRWKP 60

Query: 64  T--ALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVT 121
              +LK+  EE+  A + +   L+ A+ +A + I+++H            + GV      
Sbjct: 61  DTNSLKIGTEEMQKAYDGIDSCLRNALNLAFERIKSYHEKSLPKTWMEHDEHGVLLGAKY 120

Query: 122 RPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSP---PPIADEILYAAQLCGV 178
            P+   GLYIPGG A   S++LM A PA +AG  ++ +C+P     +   +L A  +CG+
Sbjct: 121 TPLDRAGLYIPGGKAAYPSSLLMNAVPALVAGVGEIAVCTPAVGGKVNTLLLAAMHICGI 180

Query: 179 QDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSE 238
           ++ + VGGA A+AA+A+GT+++ K D I GPGN +V  AK+ V   ++   IDM AGPSE
Sbjct: 181 KEAYKVGGASAVAAMAYGTQTIKKTDVITGPGNIYVATAKKLVYGEVN---IDMIAGPSE 237

Query: 239 VLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETA 298
           + VIAD  A P  +A DLLSQAEH   +  +L+TP       V   +  ++  L R   A
Sbjct: 238 ICVIADESADPRHIAVDLLSQAEHDEMASAVLITPNQAFGAAVQRHINEEIKTLARQPIA 297

Query: 299 RQALNA-SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPES 357
           + +++    +IV  DL +CV ++N+  PEHL I T +A EL   I  AG++F+G ++PE+
Sbjct: 298 QASIDKKGAIIVASDLGECVRLANELAPEHLEIATNDAMELARQIRHAGAIFIGHFTPEA 357

Query: 358 AGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLT 417
            GDY +G NH LPT G     S LG+ +F KR ++  L+ +G S LA+    LA AE L 
Sbjct: 358 MGDYLAGPNHTLPTGGSARFYSPLGVENFMKRTSLISLNAKGISELANACMELAEAEGLG 417

Query: 418 AHKNAVTLRVNALK 431
           AH+ +V +R+ ALK
Sbjct: 418 AHRRSVVVRLEALK 431


>UniRef50_P00815 Histidinol dehydrogenase n=17 Tax=cellular organisms
           RepID=HIS2_YEAST
          Length = 799

 Score =  550 bits (1417), Expect = e-155,   Method: Composition-based stats.
 Identities = 194/431 (45%), Positives = 269/431 (62%), Gaps = 10/431 (2%)

Query: 10  NSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVS 69
            +      ++ L RP    SE I   VN I++NV+ +G+ AL EY+ KFD   ++   ++
Sbjct: 363 KASDKVGVQKALSRPIQKTSE-IMHLVNPIIENVRDKGNSALLEYTEKFDGVKLSNPVLN 421

Query: 70  AEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPV-DVETQPGVRCQQVTRPVASVG 128
           A       E L++E+K+A+ ++++N+  FH AQ      +VETQPGV C +  RP+  VG
Sbjct: 422 APFPEEYFEGLTEEMKEALDLSIENVRKFHAAQLPTETLEVETQPGVLCSRFPRPIEKVG 481

Query: 129 LYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP-----PIADEILYAAQLCGVQDVFN 183
           LYIPGG+A L ST LML  PA +A CK++V  SPP      ++ E++Y A+  G   +  
Sbjct: 482 LYIPGGTAILPSTALMLGVPAQVAQCKEIVFASPPRKSDGKVSPEVVYVAEKVGASKIVL 541

Query: 184 VGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDG-AAIDMPAGPSEVLVI 242
            GGAQA+AA+A+GTE++PKVDKI GPGN FVT AK  V        +IDMPAGPSEVLVI
Sbjct: 542 AGGAQAVAAMAYGTETIPKVDKILGPGNQFVTAAKMYVQNDTQALCSIDMPAGPSEVLVI 601

Query: 243 ADSGATPDFVASDLLSQAEHGPDSQVILLTP--AADMARRVAEAVERQLAELPRAETARQ 300
           AD  A  DFVASDLLSQAEHG DSQVIL+    +    + + +AV  Q  +LPR +  R+
Sbjct: 602 ADEDADVDFVASDLLSQAEHGIDSQVILVGVNLSEKKIQEIQDAVHNQALQLPRVDIVRK 661

Query: 301 ALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGD 360
            +  S +++     + +E+SNQY PEHLI+Q  NA + V  + +AGSVF+G ++PES GD
Sbjct: 662 CIAHSTIVLCDGYEEALEMSNQYAPEHLILQIANANDYVKLVDNAGSVFVGAYTPESCGD 721

Query: 361 YASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHK 420
           Y+SGTNH LPTYGY    S    A FQK +T Q ++ EG   +   +  +A  E L  H+
Sbjct: 722 YSSGTNHTLPTYGYARQYSGANTATFQKFITAQNITPEGLENIGRAVMCVAKKEGLDGHR 781

Query: 421 NAVTLRVNALK 431
           NAV +R++ L 
Sbjct: 782 NAVKIRMSKLG 792


>UniRef50_Q2NHT1 HisD n=1 Tax=Methanosphaera stadtmanae DSM 3091 RepID=Q2NHT1_METST
          Length = 407

 Score =  548 bits (1413), Expect = e-154,   Method: Composition-based stats.
 Identities = 164/409 (40%), Positives = 252/409 (61%), Gaps = 8/409 (1%)

Query: 28  ASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQA 87
            S  + + V +I+ NV    D+AL +Y+ KFDK  ++  KV  E I  + E +S +L++A
Sbjct: 2   NSSDVIQPVQEIIANVCENKDKALHDYTLKFDKADISDFKVPVETIKQSVENISPKLRKA 61

Query: 88  MAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLAT 147
           +  A +NI  FH AQ      +  + GV+  Q+ RP++ VG YIPGG A   S++LM   
Sbjct: 62  LEDAAENISKFHKAQIPSDWTMTVKDGVKAGQIIRPLSRVGCYIPGGRAAYPSSILMTVI 121

Query: 148 PASIAGCKKVVLCSPPP----IADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKV 203
           PA IAG ++++ C+PP     ++DEIL AA + GV D++ VGGAQAIAA+A+ T+++P V
Sbjct: 122 PAKIAGVEEIICCTPPDKDGCVSDEILAAAYIAGVTDIYMVGGAQAIAAMAYSTQTIPSV 181

Query: 204 DKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHG 263
           DKI GPGN FV  AK+ V   +D   I+ PAGPSE+L + D  A P+++A++LL+QAEH 
Sbjct: 182 DKIVGPGNIFVATAKKLVYGDVD---IEFPAGPSEMLALVDETANPEYIATELLAQAEHD 238

Query: 264 PDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVEISNQ 322
           P++  IL++ + ++A++  E V   L    R++   ++L     ++V   +   ++ +N 
Sbjct: 239 PNAATILVSTSKEVAQKTVEHVMEYLKTQKRSDIIEESLSKYGHVLVASSMEDAIDFTNA 298

Query: 323 YGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLG 382
           Y PEHL+I T++  + ++SI +AGS+FLG+ +P + GDY SGTNHVLPT G     S L 
Sbjct: 299 YAPEHLVIVTKDHYKTLESINNAGSIFLGNLTPVAGGDYGSGTNHVLPTSGGARMYSGLS 358

Query: 383 LADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNALK 431
              F K+ T+QELS EG   +   +  LA AE L AH  ++  R   ++
Sbjct: 359 AESFLKKPTIQELSPEGVKNIKDMVINLAEAEGLYAHALSIKKRAEDME 407


>UniRef50_C9LTV1 Histidinol dehydrogenase n=1 Tax=Selenomonas sputigena ATCC 35185
           RepID=C9LTV1_9FIRM
          Length = 449

 Score =  547 bits (1411), Expect = e-154,   Method: Composition-based stats.
 Identities = 164/452 (36%), Positives = 246/452 (54%), Gaps = 26/452 (5%)

Query: 4   NTIIDWNSCTAEQQRQLLMRP---AISASESITRTVNDI--------------LDNVKAR 46
             I+       ++ R+LL++P    +  +  I      I              +++V+  
Sbjct: 1   MKIVSAKELGKDKIRKLLVKPPFDEVQLNPKIREANRKIFGADLTAAEVAVRIVEDVRRH 60

Query: 47  GDEALREYSAKFDKTT--VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKL 104
           GDEA+ +Y+   D T       +VS EE A A +     +  ++  A  N+ ++H  QK 
Sbjct: 61  GDEAVIKYTKLIDGTDFSPEDFQVSEEEFAEAEKNADPAIVASLQRAAHNVRSYHEEQKA 120

Query: 105 PPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP 164
                  + G    Q   P+   G+Y+PGG+A   S+VLM A PA++AG  ++++  PP 
Sbjct: 121 NSWLTYREKGSILGQSLIPLDRAGIYVPGGTAAYPSSVLMNAVPAAVAGVGEIIMMVPPK 180

Query: 165 ---IADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQV 221
              I   +L AA++ GV  V+ +GGAQAIAA+A+GT ++P+VDKI GPGN FVT AK+ V
Sbjct: 181 NGKINPYVLLAAKIAGVSKVYKIGGAQAIAAMAYGTATIPRVDKITGPGNIFVTLAKKAV 240

Query: 222 SQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRV 281
               D   IDM AGPSE+L++AD  A P + A+D+LSQAEH   +  IL+T +A +A  V
Sbjct: 241 YGHCD---IDMLAGPSEILIVADETADPAYTAADMLSQAEHDTLASSILITTSAKLAHEV 297

Query: 282 AEAVERQLAELPRAETARQALNA-SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVD 340
              +E QL  LPR   AR ++     +++  D+ + +E +N   PEH+ + T+   EL+ 
Sbjct: 298 EALLEEQLKGLPRENIARASIENNGLIVIADDIMEALEYANISAPEHMELLTKQPFELLP 357

Query: 341 SITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGF 400
            +  AG+VFLG +SPE  GDY +G NHVLPT G     S L +  F KR ++   +K+  
Sbjct: 358 YVRHAGAVFLGAYSPEPLGDYFAGPNHVLPTGGTARFYSVLNVETFMKRTSIISYTKDAL 417

Query: 401 SALASTIETLAAAERLTAHKNAVTLRVNALKE 432
             + + I  LA AE L AH NAV LR    K+
Sbjct: 418 HDVEADIIRLAEAEGLHAHANAVRLRSKERKD 449


>UniRef50_C0QG33 Histidinol dehydrogenase n=4 Tax=Deltaproteobacteria
           RepID=C0QG33_DESAH
          Length = 432

 Score =  545 bits (1405), Expect = e-153,   Method: Composition-based stats.
 Identities = 177/435 (40%), Positives = 249/435 (57%), Gaps = 13/435 (2%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFD--KT 61
             I  + S   EQ+    ++  +  +    R V   +++V+ RGD+AL EY+ +FD  + 
Sbjct: 1   MKIYTYPSPEGEQRICDTLKRGLGFTPENQRAVEAYIEDVRTRGDQALVEYTNQFDSSQV 60

Query: 62  TVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVT 121
           T   LKVS +EI  A   +  +  +A+  AV  + TFH+ Q+        + GV   Q+ 
Sbjct: 61  TRDTLKVSQQEIEEAKTLVDSDFSRALDRAVDQLGTFHSRQRQNSWIDTPRNGVMVGQMV 120

Query: 122 RPVASVGLYIPG---GSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQ 174
            PV + G+Y PG   G  PL S+VLM   PA +AG K   L +PP     I   +L AA 
Sbjct: 121 NPVDAAGIYAPGAKGGKTPLVSSVLMGGIPARVAGVKSCCLMTPPMENGKINPYMLVAAD 180

Query: 175 LCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPA 234
             G+  +F  G A AIAALAFGTESVPKVD I GPGN FVT AK+ VS  +    IDM A
Sbjct: 181 RVGINAIFKAGSAWAIAALAFGTESVPKVDVIVGPGNIFVTLAKKIVSGIV---GIDMIA 237

Query: 235 GPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPR 294
           GPSE+L+IAD GA PD +A+DLLSQAEH P +  IL+T + +MA R   A+E Q+  L R
Sbjct: 238 GPSEILIIADKGANPDHIAADLLSQAEHDPMASAILVTDSMEMATRTKAALEIQVKALGR 297

Query: 295 AETARQALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDW 353
            + A+++++    ++   D+   + ++N+  PEHL +   N  + V  I +AG+VFLG +
Sbjct: 298 RQIAQRSIDDFGAIMKVPDIDTAIALANRLAPEHLELIVDNPFDQVGKIKNAGAVFLGPY 357

Query: 354 SPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAA 413
           +PE  GDY +G NHVLPT G     S+LG+ +F KR ++   SKE F   A  +  LA  
Sbjct: 358 TPEPMGDYIAGPNHVLPTAGTARFSSALGVDNFTKRTSLINYSKEAFDREAQDVMVLANI 417

Query: 414 ERLTAHKNAVTLRVN 428
           E L AH N+V +R  
Sbjct: 418 EGLGAHANSVRIRTK 432


>UniRef50_C9KKX1 Histidinol dehydrogenase n=1 Tax=Mitsuokella multacida DSM 20544
           RepID=C9KKX1_9FIRM
          Length = 447

 Score =  544 bits (1403), Expect = e-153,   Method: Composition-based stats.
 Identities = 156/433 (36%), Positives = 242/433 (55%), Gaps = 9/433 (2%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
             T   ++      + +   +       +    V  I+ +V+  GD A+  Y+   D+  
Sbjct: 17  MLTKASFDEVELSPKIREANKKTFGRDMTAAELVRQIVGDVRREGDAAVIRYTHLIDRVD 76

Query: 63  --VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQV 120
                  V+  E  AA +     + +++  A +N+  +H  QK        + G    Q 
Sbjct: 77  YKPEDFLVTEAEYEAAEKAADPAVVESLRKAAENVRRYHQEQKPNSWMTYREKGSILGQS 136

Query: 121 TRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCG 177
             P+  VG+Y+PGG+A   S+V+M A PAS+AG  ++++  PP    I   +L AA+  G
Sbjct: 137 IIPLDRVGIYVPGGTAAYPSSVIMNAVPASVAGVGEIIMMVPPKNGKINPYVLIAARAAG 196

Query: 178 VQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPS 237
           V+ ++ +GGAQAIAA+AFGTE++P+VDKI GPGN FVT AK++V   +D   IDM AGPS
Sbjct: 197 VKKIYKIGGAQAIAAMAFGTETIPRVDKITGPGNIFVTLAKKEVYGHVD---IDMLAGPS 253

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAET 297
           E+L++AD  A P + A+D+LSQAEH P +  I++T  A++A +VA+  E+QLA LPR E 
Sbjct: 254 EILIVADKTADPVYTAADMLSQAEHDPLASSIVITDDAELAEKVAKEAEKQLAALPRREI 313

Query: 298 ARQALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPE 356
           A+ +++    ++V  D+ Q +  +N   PEH+ + T    +L+  +  AG+VFLG +SPE
Sbjct: 314 AQASIDRNGLIVVADDMMQAMRFANVSAPEHMELLTAQPFQLLPYVRHAGAVFLGAYSPE 373

Query: 357 SAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERL 416
             GDY +G NHVLPT G     S L +  F KR ++   ++   S ++  I  LA  E L
Sbjct: 374 PLGDYFAGPNHVLPTGGTARYYSVLNVETFMKRTSIISYTQPALSDVSEDIIRLAETEGL 433

Query: 417 TAHKNAVTLRVNA 429
            AH NA+ +R   
Sbjct: 434 QAHANAIRIRREQ 446


>UniRef50_B2KCM4 Histidinol dehydrogenase n=1 Tax=Elusimicrobium minutum Pei191
           RepID=B2KCM4_ELUMP
          Length = 429

 Score =  543 bits (1401), Expect = e-153,   Method: Composition-based stats.
 Identities = 198/433 (45%), Positives = 280/433 (64%), Gaps = 9/433 (2%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
             I ++ + T ++ + L  R  +   E + + V +    V  RGD+A++E +A FD  T+
Sbjct: 1   MKIYNYATLTKKEIKALSERSYL-MPEKLKQAVWETGLQVMKRGDKAIKELTAAFDGVTL 59

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQ-KLPPVDVETQPGVRCQQVTR 122
           ++LKVS +E   A + +S+ELK A+  A +NI  FH +Q K     +ET  G+ C +  +
Sbjct: 60  SSLKVSVKEFKQAEKLVSNELKDAIKTASENIAKFHKSQLKTKEPVIETSKGIECWREFK 119

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGV 178
            + + GLY+PGGSAPLFSTVLMLA PA IAGCKKV +C+PP     IA EIL+AA+  GV
Sbjct: 120 ALGTAGLYVPGGSAPLFSTVLMLAVPAKIAGCKKVYICTPPCKNGLIAPEILFAAKTAGV 179

Query: 179 QDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSE 238
            +V+ +GGAQA+ A+A+GT++VPK DKIFGPGN +VT+AK +VS      AIDMPAGPSE
Sbjct: 180 DEVYKIGGAQAVFAMAYGTQTVPKADKIFGPGNQYVTQAKMEVSS---FTAIDMPAGPSE 236

Query: 239 VLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETA 298
           VL+IA+      + A+D+LSQAEHGPDSQ +L   + +  + +   V+ QL +L R   A
Sbjct: 237 VLIIAEESTNASYAAADILSQAEHGPDSQAVLACSSKNKIKEIIAEVDAQLKKLGRKSIA 296

Query: 299 RQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESA 358
            +AL  S ++ T++  + VE SN Y PEHLI+  ++ ++ + S+ +AGSVF G  + ES 
Sbjct: 297 AKALGKSFIMQTRNTKESVEFSNIYAPEHLILNFKDWKKYLTSVQNAGSVFCGTLATESF 356

Query: 359 GDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTA 418
           GDYASGTNH LPT G+  +   L    F K +T Q +S +G   L  T+E +A AE LTA
Sbjct: 357 GDYASGTNHTLPTSGFAKSFGGLNTQSFGKWITYQTVSAQGLRGLGKTVEIMAEAEGLTA 416

Query: 419 HKNAVTLRVNALK 431
           HKNAVT+R+   K
Sbjct: 417 HKNAVTIRIENEK 429


>UniRef50_Q5FS83 Histidinol dehydrogenase n=3 Tax=Bacteria RepID=HISX_GLUOX
          Length = 430

 Score =  542 bits (1396), Expect = e-152,   Method: Composition-based stats.
 Identities = 177/432 (40%), Positives = 252/432 (58%), Gaps = 9/432 (2%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
              +D ++    +    L+    S   S+   V  IL +V++RGDEAL +Y+A+FD+ T+
Sbjct: 1   MKRLDTSAAGFSEDFATLLAARGSDERSVAEPVRAILADVRSRGDEALCDYTARFDRLTL 60

Query: 64  --TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVT 121
               L++SAEEIA+ + R+  +L  A+  A + IETFH AQ    +D   + G+R     
Sbjct: 61  PAEKLRISAEEIASEAARVPADLMDALRTAARRIETFHAAQMPKDLDFTDEDGIRLGMRW 120

Query: 122 RPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCGV 178
            P+ +VGLY+PGG A   S+VLM A PA +AG K++ +C P P   +   +L AAQLCGV
Sbjct: 121 TPLDAVGLYVPGGKAAYPSSVLMNALPARVAGVKRLAMCVPSPDGVLNPLVLAAAQLCGV 180

Query: 179 QDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSE 238
           ++++ +GGAQA+ A+AFGT+ +  VD+I GPGNA+V EAKRQV   +    ID  AGPSE
Sbjct: 181 EEIYRIGGAQAVGAMAFGTDLIAPVDRIVGPGNAYVAEAKRQVFGHV---GIDSIAGPSE 237

Query: 239 VLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETA 298
           V+V+AD    P  VA DLL+QAEH   +Q IL+T  A  A R AEAV ++L  LPR   A
Sbjct: 238 VVVVADGQNDPRLVALDLLAQAEHDEQAQAILITTDAAFAERAAEAVRKELETLPRTAIA 297

Query: 299 RQAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPES 357
            ++  +   +IV + L +  EI N   PEHL +     R+    I  AG++F+G + PE+
Sbjct: 298 SKSWEDHGAIIVVRSLEEAAEIVNALAPEHLEVMLDAPRDFSAMIRHAGAIFMGRYCPEA 357

Query: 358 AGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLT 417
            GDY  G NHVLPT       S L + DF KR T  E  + G   +      LA AE L 
Sbjct: 358 VGDYVGGPNHVLPTSRTARFASGLSVFDFIKRTTTIEADEAGLRRIGPAGVALAKAEGLD 417

Query: 418 AHKNAVTLRVNA 429
           AH  ++++R+  
Sbjct: 418 AHALSLSVRLEK 429


>UniRef50_Q1Q2D0 Histidinol dehydrogenase n=1 Tax=Candidatus Kuenenia
           stuttgartiensis RepID=Q1Q2D0_9BACT
          Length = 439

 Score =  541 bits (1394), Expect = e-152,   Method: Composition-based stats.
 Identities = 167/439 (38%), Positives = 264/439 (60%), Gaps = 13/439 (2%)

Query: 4   NTIIDWNSCTAEQQRQLLMRP--AISASESITRTVNDILDNVKARGDEALREYSAKFDKT 61
             I+    C A  + + + +    +++S  I  TV  I+ +VK  GD+A+  Y  +FDK 
Sbjct: 1   MRILKTWECDASLEIEKIKQGLDPLNSSSDIRTTVLKIIQDVKKNGDKAIAAYGKRFDKA 60

Query: 62  TVTA--LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQ 119
            ++    +V  EEI  A + ++ +  +A+ +A+KNI+T+    ++  V      GV    
Sbjct: 61  PLSPEQFRVKEEEIEDAYKYVTGKFIKAIRLAIKNIQTYQNHIRIQNVKPLRSKGVILDT 120

Query: 120 VTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQL 175
           +  P+ S G+Y+PGG+A   STVLM A PA +AG +K+V+ SPP     I  E L AA+ 
Sbjct: 121 IYTPIDSAGIYVPGGAASYPSTVLMNAIPAQVAGVEKIVMVSPPKEDGNIPPERLVAAKE 180

Query: 176 CGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAG 235
            GV +++ +GG QAIAALAFGT+++P VDKI GPGN FVT AK+++      A IDM AG
Sbjct: 181 AGVSEIYKIGGVQAIAALAFGTKTIPSVDKIVGPGNVFVTLAKKEIFGY---AGIDMLAG 237

Query: 236 PSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRA 295
           PSEVL+IAD+ A P ++ASDLLSQAEH P    +L+T +  +A++V   +  Q+  L R+
Sbjct: 238 PSEVLIIADNHANPSYIASDLLSQAEHTPG-ISLLVTSSKLLAKQVLAEITLQIKTLSRS 296

Query: 296 ETARQAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWS 354
               + L     + +TK++ +C+ +SN   PEHL I T+N + ++  I  AG+VF+GD++
Sbjct: 297 AGTNECLCKYGVIFITKNMNECIALSNAIAPEHLQIMTQNPKAVLSGIKHAGAVFVGDYT 356

Query: 355 PESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAE 414
           P + GDY +G +HVLPT G     S L + DF KR +V   S+    ++   +  ++A+E
Sbjct: 357 PVALGDYIAGPSHVLPTGGTARFSSGLSVNDFIKRTSVITYSQSALRSVQQDVSEISASE 416

Query: 415 RLTAHKNAVTLRVNALKEQ 433
            L AH  +V +R+++ +++
Sbjct: 417 GLDAHAKSVKIRLDSGRKK 435


>UniRef50_D2RJQ0 Histidinol dehydrogenase n=7 Tax=Firmicutes RepID=D2RJQ0_ACIFE
          Length = 448

 Score =  539 bits (1389), Expect = e-152,   Method: Composition-based stats.
 Identities = 176/451 (39%), Positives = 257/451 (56%), Gaps = 27/451 (5%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISA---SESITRTVND--------------ILDNVKAR 46
             + D    TAE+  +LL + +      S  +   V                I+++++ +
Sbjct: 1   MKVYDERKSTAEEISRLLEKKSFDEVKLSPKVAAAVEKMFGRPLTAAEEVDIIVNDIRNK 60

Query: 47  GDEALREYSAKFDKTTVTA--LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKL 104
           GDEAL EY+ K D   +    ++V+ EE A A + + ++   A+  A+ N+  FH  Q  
Sbjct: 61  GDEALFEYTKKLDGADLRPATIRVTEEEFAEAEKAVDEKTMGAIRRAIANVRKFHEEQLP 120

Query: 105 PPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSP-- 162
                    G    Q   PV SVG+Y+PGG+A   S+V+M A PA +AG  ++ + +P  
Sbjct: 121 KTWLTPRAYGSFLGQKMTPVDSVGIYVPGGTAAYPSSVIMNAVPAKVAGVPRIAMAAPAG 180

Query: 163 --PPIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQ 220
               +   +L  A+  G+ +++ +GGAQAIAALAFGTE++PKV+KI GPGN FVT AK+ 
Sbjct: 181 RDGKMNPYVLATAKEIGITEIYKMGGAQAIAALAFGTETIPKVEKITGPGNIFVTLAKKA 240

Query: 221 VSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARR 280
           V   +D   IDM AGPSE+L++AD  A   ++A+DLLSQAEH P +  IL+T   D+A +
Sbjct: 241 VYGHVD---IDMLAGPSEILIVADKTADYQYLAADLLSQAEHDPLACAILITDDEDLAGK 297

Query: 281 VAEAVERQLAELPRAETARQALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELV 339
           VAE VE QL +LPR E A Q+L    ++I+ KD+   VE++N   PEH+ I TR    LV
Sbjct: 298 VAEEVEVQLQKLPRKEIAAQSLAVQGKIILAKDMDTVVEMANISAPEHMEINTREPFALV 357

Query: 340 DSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEG 399
             I +AG++FLG +SPE  GDY +G NH+LPT G     S L +  F K+ ++   +KE 
Sbjct: 358 PRIRNAGAIFLGAYSPEPLGDYYAGPNHILPTGGTARFYSVLNVETFMKKTSIISYTKEA 417

Query: 400 FSALASTIETLAAAERLTAHKNAVTLRVNAL 430
            +  A  I  +A AE L AH NA+ +R  AL
Sbjct: 418 LAEAADDIIAMAEAEGLQAHANAIRIRKGAL 448


>UniRef50_B2A652 Histidinol dehydrogenase n=1 Tax=Natranaerobius thermophilus
           JW/NM-WN-LF RepID=B2A652_NATTJ
          Length = 428

 Score =  538 bits (1386), Expect = e-151,   Method: Composition-based stats.
 Identities = 165/421 (39%), Positives = 245/421 (58%), Gaps = 11/421 (2%)

Query: 16  QQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAA 75
           ++ +L  + A         TV  I+D V+  GD+AL E +   D  +++ L+VS E +  
Sbjct: 5   KEAKLASQKAKFEDVETRNTVTKIIDQVRTNGDKALFELTQSLDNCSLSKLEVSQEYMKQ 64

Query: 76  ASERLSDELKQAMAVAVKNIETFHTAQK--LPPVDVETQPGVRCQQVTRPVASVGLYIPG 133
             + L+D+ K+A+  A   IE F + Q      ++ E  PGV+     +P++S G Y+P 
Sbjct: 65  CYDNLTDKTKEALNFAKDQIEFFASQQLAGFKEIECENIPGVKLGYKIKPISSCGCYVPA 124

Query: 134 GSAPLFSTVLMLATPASIAGCKKVVLCSPP-----PIADEILYAAQLCGVQDVFNVGGAQ 188
           G  PL S+ LM   PA +AG +++V  +PP      I  E+L A  L GV +V+ VGGA 
Sbjct: 125 GRYPLPSSALMSIVPARVAGVERIVAIAPPVRKYGGIHPELLAAMYLAGVDEVYIVGGAH 184

Query: 189 AIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGAT 248
            IAALA GTE++ KVD I GPGN +VTEAKRQ++  +    ID  AGPSEVL+IAD+ A+
Sbjct: 185 GIAALALGTETISKVDFIVGPGNKYVTEAKRQLNGIV---GIDQLAGPSEVLIIADNTAS 241

Query: 249 PDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRL 307
              VA+DLL+QAEH PD+  +L+T +  +A+ V + + RQL EL   ETA ++  +   +
Sbjct: 242 STNVAADLLAQAEHDPDAVCVLVTTSEQLAKEVNQEIHRQLDELLTWETAAKSWEDYGEI 301

Query: 308 IVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNH 367
           I+  +L Q +EIS+Q  PEHL + T N   +++ +   GS+F+G+W+  + GDY SGTNH
Sbjct: 302 ILVDNLDQAIEISDQMAPEHLQLMTDNNSNIMEMVNHYGSLFVGEWASVAFGDYVSGTNH 361

Query: 368 VLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRV 427
           +LPT       S L +  F K  + Q L++ G   L+     LA  E L AHK +  LR 
Sbjct: 362 ILPTGNSARFSSGLSVGKFLKMSSYQVLTETGAHELSDKCMHLAELEGLEAHKKSAELRA 421

Query: 428 N 428
           +
Sbjct: 422 D 422


>UniRef50_B3WED5 Histidinol dehydrogenase n=21 Tax=Bacilli RepID=B3WED5_LACCB
          Length = 430

 Score =  538 bits (1386), Expect = e-151,   Method: Composition-based stats.
 Identities = 178/433 (41%), Positives = 250/433 (57%), Gaps = 8/433 (1%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
             I+   + +  +Q+  + R A++ +  +   V  I+  V+A GD ALR YS K D  TV
Sbjct: 1   MKIL-TGTLSQLKQQVDIRRTAVAQNTDVQTIVQAIIAKVRAEGDSALRTYSNKLDHVTV 59

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRP 123
              +V    I AA  +L  +L +A+ +A  NI ++H  +           G+   Q   P
Sbjct: 60  NDFQVDQALIDAAPAQLPAKLLKALQLAKANITSYHQNEIERGFVDTPNSGIIRGQKITP 119

Query: 124 VASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP---PIADEILYAAQLCGVQD 180
           +A+VGLY+PGG+A   ST+LM A PA +AG KK+V+ +PP    +   +L AA L GV  
Sbjct: 120 LAAVGLYVPGGTAAYPSTILMTAIPAKLAGVKKIVMVTPPQPDGLNPVVLAAANLAGVDA 179

Query: 181 VFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVL 240
           ++ VGGAQAIAALA+GTES+P+VDKI GPGN +V EAK+QV   +   AIDM AGPSE+ 
Sbjct: 180 IYQVGGAQAIAALAYGTESIPRVDKIMGPGNRYVAEAKKQVFGNV---AIDMIAGPSEIG 236

Query: 241 VIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQ 300
           +IAD  A P  +A+DLLSQAEH P+++ +++T +  +A  V+E ++ QL  LPR   AR 
Sbjct: 237 IIADESADPIRLAADLLSQAEHDPNARAMMVTTSEKLASAVSEQIDIQLPTLPRESIARA 296

Query: 301 ALNA-SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAG 359
           A+     + +   +     + N   PEHL +Q  +    +  I +AGSVFLG  + E  G
Sbjct: 297 AIENQGFIAIVATINDAFSLMNTIAPEHLEVQLPDPITYLAQIQNAGSVFLGQNAAEPVG 356

Query: 360 DYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAH 419
           DY +G NHVLPT G     S LG+ DF KR    + S E  ++ A  I TLA AE L  H
Sbjct: 357 DYVAGPNHVLPTAGSARFFSPLGVYDFVKRTQFIQYSSEALASQADAIVTLAQAEGLDGH 416

Query: 420 KNAVTLRVNALKE 432
             A+  RV A KE
Sbjct: 417 AEAIIKRVPAAKE 429


>UniRef50_C4V2I6 Histidinol dehydrogenase n=1 Tax=Selenomonas flueggei ATCC 43531
           RepID=C4V2I6_9FIRM
          Length = 448

 Score =  537 bits (1385), Expect = e-151,   Method: Composition-based stats.
 Identities = 165/434 (38%), Positives = 250/434 (57%), Gaps = 11/434 (2%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
                D     A  + +         + S    V+ I+ +V++ GD+AL  Y+   D   
Sbjct: 19  MKKAFDEIELGASMRAKNQEIFGEDLTAS--ELVHHIVRDVRSGGDQALLRYTKLLDGLD 76

Query: 63  VTA--LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQV 120
           +++  + VS  E+ AA+++    +  ++  A KNI  FH  QK          G    Q 
Sbjct: 77  LSSTDIMVSESELQAAADQADAAVLASLERAAKNIFAFHEEQKPKSWMTYRAHGSILGQE 136

Query: 121 TRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCG 177
             P++ VG+Y+PGG+A   S+VLM A PA +AG   +++  P     +   +L AA + G
Sbjct: 137 VIPLSRVGIYVPGGTAAYPSSVLMNAIPAIVAGVDDIIMSVPTKGGVLNPYVLAAAHMLG 196

Query: 178 VQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPS 237
           ++ +F VGGAQAIAA+A+GTES+P+VDKI GPGN FVT AK++V   +D   IDM AGPS
Sbjct: 197 IKKIFRVGGAQAIAAMAYGTESIPRVDKITGPGNLFVTLAKKEVYGYVD---IDMLAGPS 253

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAET 297
           E+L++AD  A+P ++A+D+LSQAEH P +  IL+T +AD+A  V   ++ QL  LPR ET
Sbjct: 254 EILILADEEASPKYIAADMLSQAEHDPLASSILITDSADLASNVRCEIQDQLQSLPRMET 313

Query: 298 ARQALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPE 356
           A  +L    R+IVT+++ Q V ++N  GPEH+ +  ++A  L+  I  AG+VF+G +SPE
Sbjct: 314 ASASLERNGRIIVTENIQQSVHLANYSGPEHIELLVKDAFHLLPEIRCAGAVFVGSYSPE 373

Query: 357 SAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERL 416
             GDY +G NHVLPT G     S L +  F KR ++   +++    ++  I  LA  E L
Sbjct: 374 PLGDYFAGPNHVLPTGGTARFYSVLNVETFMKRTSIISYTRKALDEVSDDIIRLAETEGL 433

Query: 417 TAHKNAVTLRVNAL 430
            AH  A+  R + +
Sbjct: 434 EAHARAIRTRRDNI 447


>UniRef50_C3XDE7 Histidinol dehydrogenase n=1 Tax=Helicobacter bilis ATCC 43879
           RepID=C3XDE7_9HELI
          Length = 452

 Score =  537 bits (1384), Expect = e-151,   Method: Composition-based stats.
 Identities = 156/455 (34%), Positives = 242/455 (53%), Gaps = 28/455 (6%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              I++ +    E +   L+  A +  +SI   V   L ++K RG++AL +   K+D   
Sbjct: 1   MIKILNIHDKDFETEFNTLLARANTDMDSIIPEVLKTLQDIKQRGEDALLDIVRKYDSWN 60

Query: 63  V---TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQ 119
                 LK++ E+   A + L  + K A+ +A   I TFH            +      Q
Sbjct: 61  PQTFNDLKIAEEDTFNAYKNLDSKTKDALQIAHDRIYTFHAKNAPKGFIYHDEYANMLGQ 120

Query: 120 VTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLC 176
              P+   G+YIPGG A   S++LM A PA +AG K++++ SP P   I + +L A  LC
Sbjct: 121 NIMPIQRAGIYIPGGKAFYPSSLLMNAIPAKVAGVKEIIMASPTPNNHINELVLAAMYLC 180

Query: 177 GVQDVFNVGGAQAIAALAFG--------------TES----VPKVDKIFGPGNAFVTEAK 218
           G+++ + +GG  AI   A+G              T++      KVD I GPGN +V  AK
Sbjct: 181 GIKEGYKIGGIGAIGMFAYGFGETKWSKDSLFSHTKTTQKGFKKVDVITGPGNIYVATAK 240

Query: 219 RQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMA 278
           + V   ++   IDM AGPSE+ +IADS A  D++A D+LSQAEH   +  IL+T   D+A
Sbjct: 241 KLVFGEVN---IDMIAGPSEIGIIADSHANSDYLAIDMLSQAEHDSMASAILITDNKDLA 297

Query: 279 RRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARE 337
           + VA+ ++ +L  L R + A++++     +I+ ++L Q   + N   PEHL I T+    
Sbjct: 298 KEVAQKIDTKLTHLMRKDIAQKSIQERGAIIIVENLKQAAMLMNAIAPEHLEIVTQEPFS 357

Query: 338 LVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSK 397
           L+  I +AG+VFLG ++PE+ GDY +G NH LPT G     S LG+  F  R ++   SK
Sbjct: 358 LLGEIKAAGAVFLGHYTPEAIGDYLAGPNHTLPTGGSARFFSPLGVEHFCTRSSLISFSK 417

Query: 398 EGFSALASTIETLAAAERLTAHKNAVTLRVNALKE 432
           +G   LA+    LA  E L AHK +V  R++++K+
Sbjct: 418 QGIKNLANPCAILAETEGLEAHKLSVISRLDSMKD 452


>UniRef50_Q2PPB3 Histidine biosynthesis trifunctional protein n=12 Tax=Phaeosphaeria
           RepID=Q2PPB3_PHANO
          Length = 881

 Score =  537 bits (1384), Expect = e-151,   Method: Composition-based stats.
 Identities = 199/432 (46%), Positives = 265/432 (61%), Gaps = 8/432 (1%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
                    T+E     L RP+  ++  I      I+D VK RGD AL EY+ KF+K T 
Sbjct: 447 MKRYVTAQETSETIAAALQRPSQKSTGKIIGICRPIIDAVKTRGDAALLEYTHKFEKATS 506

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKL-PPVDVETQPGVRCQQVTR 122
               V          +L+ E  +A+ V+ +NI  FH AQ+   P+ VET PGV C +  R
Sbjct: 507 LTSPVLRAPFPPELMQLAPETAKAIDVSFENIRKFHAAQREEKPLVVETMPGVVCSRFAR 566

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGV 178
           P+  VGLY+PGG+A L ST LML  PA +AGCKK+VL +PP     +  E++YAA   G 
Sbjct: 567 PIERVGLYVPGGTAVLPSTALMLGVPAMVAGCKKIVLATPPRSNGKVTPEVVYAAHKVGA 626

Query: 179 QDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLD-GAAIDMPAGPS 237
           + +   GGAQA+AA+A+GTESV KVDKI GPGN FVT AK  VS   + G +IDMPAGPS
Sbjct: 627 EMIVLAGGAQAVAAMAYGTESVSKVDKILGPGNQFVTAAKMHVSNDTNAGVSIDMPAGPS 686

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTP--AADMARRVAEAVERQLAELPRA 295
           E+LVIAD+ A P FVASDLLSQAEHG DSQVIL+           + + + +Q   LPR 
Sbjct: 687 ELLVIADASANPAFVASDLLSQAEHGVDSQVILIAVGLNEAQLTAIEDELHKQANALPRV 746

Query: 296 ETARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSP 355
           +  R A+  S  +    + + +E+SNQY PEHLI+Q  NA ++V+ + +AGSVF+G+W+P
Sbjct: 747 DIVRGAIEHSLTLAASTIEEALELSNQYAPEHLILQVANADKVVELVENAGSVFIGEWTP 806

Query: 356 ESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAER 415
           ES GDY++G NH LPTYGY    S + LA + K +T   L+KEG   +   +  LA  E 
Sbjct: 807 ESVGDYSAGVNHSLPTYGYAKQYSGVNLASYVKHITSAHLTKEGLQNVGPAVMELARVEE 866

Query: 416 LTAHKNAVTLRV 427
           L AH+ AV+LR+
Sbjct: 867 LEAHRRAVSLRL 878


>UniRef50_Q3J079 Histidinol dehydrogenase 1 n=26 Tax=Proteobacteria
           RepID=HISX1_RHOS4
          Length = 434

 Score =  536 bits (1382), Expect = e-151,   Method: Composition-based stats.
 Identities = 171/436 (39%), Positives = 242/436 (55%), Gaps = 9/436 (2%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
               +D      E     L+      S  +   V  I+ +V+ARGD A+ E +A+FD+  
Sbjct: 1   MPQFLDTRRPGFEADFTALLGMKREDSPDVDAVVAGIIADVRARGDAAVIELTARFDRLE 60

Query: 63  VTALKV--SAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQV 120
           +T  ++  S  EI A    +S E + A+ +A + I  +H  Q           G      
Sbjct: 61  LTPERLAFSEAEIEAEIATVSAEDRAALELAAERIRAYHARQMPENARWTDAAGAELGWR 120

Query: 121 TRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCG 177
             P+AS GLY+PGG A   S+VLM A PA +AG +++V+  P P   +   +L AA+L G
Sbjct: 121 WGPIASAGLYVPGGLASYPSSVLMNAIPARVAGVERLVVACPTPGGVVNPLVLLAARLAG 180

Query: 178 VQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPS 237
           V  V+ +GGAQA+AALA+GTE++  VDKI GPGNA+V  AKR+V  R+    IDM AGPS
Sbjct: 181 VDAVYRIGGAQAVAALAYGTETIRPVDKITGPGNAYVAAAKRRVFGRV---GIDMIAGPS 237

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAET 297
           E+LVIA+    PD++A DLLSQAEH   +Q IL+TP   + R V +AVE +L  L R   
Sbjct: 238 EILVIAEGAVDPDWIALDLLSQAEHDESAQSILVTPDEALGRAVVQAVEARLETLERRAI 297

Query: 298 ARQAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPE 356
           A  +  +   +IVT+DL +   +S++  PEHL +   +   L   I  AG++FLG W+PE
Sbjct: 298 AGASWRDYGAVIVTRDLEEAAALSDRVAPEHLELCVADPEALAARIRHAGAIFLGGWTPE 357

Query: 357 SAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERL 416
           + GDY  G NHVLPT       S L + DF KR T+  ++     A+    E LA +E L
Sbjct: 358 AIGDYVGGPNHVLPTARSARFSSGLSVMDFLKRTTLARMTPAALRAVGPAAERLAISESL 417

Query: 417 TAHKNAVTLRVNALKE 432
            AH  +V  R++ L E
Sbjct: 418 EAHGLSVRARLDRLNE 433


>UniRef50_B3TCH3 Putative Histidinol dehydrogenase n=1 Tax=uncultured marine
           microorganism HF4000_APKG10K24 RepID=B3TCH3_9ZZZZ
          Length = 444

 Score =  536 bits (1382), Expect = e-151,   Method: Composition-based stats.
 Identities = 159/434 (36%), Positives = 244/434 (56%), Gaps = 13/434 (2%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
              +D +        +         S    ++V  +L +V+  GD A+R YS   D   +
Sbjct: 15  IDPLDLSDLPKAVLDRTHQAFGEDVSPE--QSVLKMLQDVRQDGDAAVRRYSKLLDGVEL 72

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRP 123
           ++ KV  E++A A+  +S EL++++ +A + I  FH A        E        Q+ RP
Sbjct: 73  SSFKVEKEQLAQAAASVSTELRESLELAAERIRQFHQAVMPKDWLDEEGG---LGQLVRP 129

Query: 124 VASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQ 179
           +  VGLY PGG+A   STVLM A PA +AG  +V+LC+P      +   +L AA++ GV 
Sbjct: 130 LERVGLYAPGGTAAYPSTVLMTAIPARVAGVNEVILCTPARPGEALNPAVLVAAEISGVD 189

Query: 180 DVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEV 239
            V+ +GG  AI A+A+GT+SVPKVDKI GPGN FV  AK+ V  ++D   ID   GP+E 
Sbjct: 190 TVYQIGGVPAIGAMAYGTDSVPKVDKICGPGNVFVAYAKKLVQGQVD---IDGVFGPTET 246

Query: 240 LVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETAR 299
           +VIAD  A P F A+DL+ QAEH P +  IL+T + D+  RV   ++ QL    R + AR
Sbjct: 247 VVIADESADPGFCAADLIGQAEHDPLATAILITDSQDLIDRVERELDEQLNIQLRGDLAR 306

Query: 300 QALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESA 358
           QAL    R+++ + +A+ VE++++  PEH+ +  ++  +   ++  AG +FLG++SPE  
Sbjct: 307 QALERQGRIVLVESVAEAVELADRIAPEHMCLMVQDPWKWAGTVKHAGGLFLGEYSPEVM 366

Query: 359 GDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTA 418
           GDY +G +HV+PT G     S+L +  F + M V  LS + F  L      +A AE L  
Sbjct: 367 GDYVAGPSHVMPTGGTARFSSALSVHQFLRTMPVVSLSADDFQKLGPAAIEIAKAEGLDG 426

Query: 419 HKNAVTLRVNALKE 432
           H  AV +R++ L++
Sbjct: 427 HATAVRMRLDKLQK 440


>UniRef50_C1PFR7 Histidinol dehydrogenase n=1 Tax=Bacillus coagulans 36D1
           RepID=C1PFR7_BACCO
          Length = 427

 Score =  535 bits (1380), Expect = e-151,   Method: Composition-based stats.
 Identities = 152/429 (35%), Positives = 234/429 (54%), Gaps = 8/429 (1%)

Query: 5   TIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVT 64
            I ++      +        +    E + RT  ++L++++  GD A+++Y+AKFD     
Sbjct: 1   MIREYTKEAFAETFLQSKNKSGVHDEGVLRTAKEVLEDIRLNGDAAVKKYTAKFDGEVPE 60

Query: 65  ALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPV 124
           + +V  EE   A   +  ++  A+  A +NI  FH  Q      +E    +   Q+ RPV
Sbjct: 61  SWEVLPEERKQAWHEVPQDVISALQKAAENIRRFHAKQLQNSRIMEMNENIISGQLFRPV 120

Query: 125 ASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQD 180
              G+Y+PGG+A   S+VLM A PA +AG ++V++ +P      IA  +  AA + GV  
Sbjct: 121 EKAGIYVPGGTACYPSSVLMNAIPAVLAGVEEVIMATPARNGTKIAPVLSVAADIAGVGT 180

Query: 181 VFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVL 240
           ++ +GG QAI ALA+GTE++PKVDKI GPGNA+V  AK  V   +    IDM AGPSEV 
Sbjct: 181 IYKLGGIQAIGALAYGTETIPKVDKIVGPGNAYVAAAKSLVYGTV---GIDMIAGPSEVA 237

Query: 241 VIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQ 300
           +IAD  A P ++A+DL++QAEH   ++  L T +  +      A+E+QL  LPR +    
Sbjct: 238 IIADENANPVYIAADLIAQAEHDERARTFLFTTSQKLINETKSALEKQLVVLPRRDIGEV 297

Query: 301 ALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAG 359
           ++   S  ++ + + +   +SN+  PEHL IQ  N    +  + +AGSVFLG+ +PE+ G
Sbjct: 298 SIKMQSAAVLVESIDEAFALSNRLAPEHLEIQVENPLLQLSKVKNAGSVFLGENTPEAIG 357

Query: 360 DYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAH 419
           DY  G NH+LPT G     S L + DF K++T     ++     A  +  +A  E+L  H
Sbjct: 358 DYYGGPNHILPTSGTARFSSGLSVDDFYKKITYLYYGEKALQQAAPDVMAIATEEQLAGH 417

Query: 420 KNAVTLRVN 428
             AV  RV 
Sbjct: 418 ARAVQKRVK 426


>UniRef50_Q3AR25 Histidinol dehydrogenase n=13 Tax=Bacteria RepID=HISX_CHLCH
          Length = 428

 Score =  535 bits (1380), Expect = e-150,   Method: Composition-based stats.
 Identities = 150/435 (34%), Positives = 228/435 (52%), Gaps = 14/435 (3%)

Query: 3   FNTIIDWNSCTAEQQRQLLMR--PAISASESITRTVNDILDNVKARGDEALREYSAKFDK 60
              +        ++   L  R    +S  E+  + V++IL  V+ +GD A+  Y+ +F  
Sbjct: 1   MLPLYR----FPQEASALQERLVRHVSFDEAAHKAVDEILAKVRQQGDRAVLNYTEQFQG 56

Query: 61  TTVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQV 120
             +T+++V  E I  A       L   +  A  NI  FH  +       E + GV   Q 
Sbjct: 57  VRLTSMQVDEEAIEMAYRHADPSLIATLHEAYANIVRFHEHEVERSFFYEAEGGVLLGQR 116

Query: 121 TRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSP----PPIADEILYAAQLC 176
            RP+    LY+PGG A   S++LM A PA +AG  ++ + +P      +   IL AA++ 
Sbjct: 117 VRPMERAMLYVPGGKAAYPSSLLMNAAPAKVAGVCEIAVTTPCDATGVVNPTILAAAKVA 176

Query: 177 GVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGP 236
           G+  ++ +GGAQA+AA A+GTES+PKVD I GPGN +V  AK+QV   +   AID  AGP
Sbjct: 177 GISSIYKIGGAQAVAAFAYGTESIPKVDIITGPGNKYVALAKKQVFGHV---AIDSIAGP 233

Query: 237 SEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAE 296
           SEV++IAD  A  +FVA D+ +QAEH PD+  +L+T +   A+ V +AV   L  + R E
Sbjct: 234 SEVVIIADESAHAEFVALDMFAQAEHDPDASAVLITTSESFAQAVQQAVASLLPTMLRHE 293

Query: 297 -TARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSP 355
             A   L+   +++   L     +S+   PEHL +      +++  +  AG++F+G +S 
Sbjct: 294 TIASSLLHNGAMVLVPSLDDACAVSDMLAPEHLELHVVQPWDILPKLKHAGAIFMGSYSC 353

Query: 356 ESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAER 415
           E+ GDY +G NH LPT G     S L + DF K  ++   S E   +  + I   A AE 
Sbjct: 354 ETIGDYFAGPNHTLPTSGTARFFSPLSVRDFVKHTSIISYSPEQLRSKGAQIAAFADAEG 413

Query: 416 LTAHKNAVTLRVNAL 430
           L AH  AV +R+  L
Sbjct: 414 LQAHAEAVRVRLKTL 428


>UniRef50_Q313T7 Histidinol dehydrogenase n=7 Tax=Deltaproteobacteria
           RepID=HISX_DESDG
          Length = 434

 Score =  534 bits (1377), Expect = e-150,   Method: Composition-based stats.
 Identities = 167/438 (38%), Positives = 249/438 (56%), Gaps = 14/438 (3%)

Query: 1   MSFNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFD- 59
           M   T+   +    +  R +L     +   S+   V +I+D +++ GD AL  Y+ +FD 
Sbjct: 1   MPCRTLTYSSEADWQGIRDMLC-GRENPENSVEPVVREIMDAIRSDGDAALAGYTRRFDC 59

Query: 60  -KTTVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQ 118
                ++L+V+ + I  A+  +     Q +  A  NI  FH+AQK     +    G    
Sbjct: 60  PDFDPSSLRVAPDAIEKAAREIPRHDLQIITEAADNIRHFHSAQKEEAWFITRPDGTVLG 119

Query: 119 QVTRPVASVGLYIPGGSA---PLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILY 171
           Q+TRPV S GLY+PGG     PL S++LM A PA +AG  ++ + +PP     +   IL 
Sbjct: 120 QMTRPVDSAGLYVPGGQGGNTPLISSLLMNAVPAQVAGVPRIAVTTPPRKDGTLNPYILA 179

Query: 172 AAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAID 231
           AA + G+ +++  G A A+AALA+GT+++  VD I GPGN FVT AKR +   +    ID
Sbjct: 180 AAHVLGLDEIYCAGSAWAVAALAYGTQTIAPVDFIAGPGNIFVTTAKRMLIGTV---GID 236

Query: 232 MPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAE 291
           M AGPSE+L+IADS A    VA+D+LSQAEH P +  IL+TP+  +A  V   +E+Q+  
Sbjct: 237 MIAGPSEILIIADSQADAAHVAADMLSQAEHDPLASAILVTPSPQLAAAVHTELEKQVTG 296

Query: 292 LPRAETARQAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFL 350
           L RA+ AR +L + S ++VT DL   VE+SN+  PEHL +  ++   L+ SI +AG++F+
Sbjct: 297 LDRADIARASLRDWSAIVVTPDLNSAVELSNKVAPEHLELLVQDTWGLLGSIRNAGAIFM 356

Query: 351 GDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETL 410
           G  SPE  GDY +G NHVLPT G     S+L +  F K+ ++   S+      A+ I  L
Sbjct: 357 GPHSPEPVGDYFAGPNHVLPTMGTARFSSALSVQSFCKKSSIIAASQTFTQTNAAKIARL 416

Query: 411 AAAERLTAHKNAVTLRVN 428
           A  E L AH  +V  R++
Sbjct: 417 ARLEGLEAHARSVESRLS 434


>UniRef50_Q186D5 Histidinol dehydrogenase n=9 Tax=Bacteria RepID=Q186D5_CLOD6
          Length = 421

 Score =  533 bits (1374), Expect = e-150,   Method: Composition-based stats.
 Identities = 156/407 (38%), Positives = 231/407 (56%), Gaps = 12/407 (2%)

Query: 32  ITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAMAVA 91
           +   V+ I+++++   D AL++Y+ KFD+ T    +++ EEI  A + + DE    + +A
Sbjct: 18  LREQVSSIIEDIRNNKDVALKKYNEKFDRNTRDEFRITKEEIKEAYKHVDDEFINNLKIA 77

Query: 92  VKNIETFHTAQK---LPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATP 148
            KNI  F  AQK     P + E  PGV   Q   P+ S   Y+PGG  PLFST LML  P
Sbjct: 78  AKNIREFAKAQKLSFENPFEKEIYPGVILGQTNIPIESCLAYVPGGQYPLFSTALMLIIP 137

Query: 149 ASIAGCKKVVLCSPP-----PIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKV 203
           A +AG K++V CSP       I  + L A  + G  +++  GG QAIAA  +GTE +  V
Sbjct: 138 AKVAGVKRIVACSPTMKNTEKINPKTLVAMDIAGADEIYATGGVQAIAAFTYGTEKINPV 197

Query: 204 DKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHG 263
           D I GPGN FVTEAKRQ   ++    ID  AGPSEVL+IAD  + P ++A+DLL+Q EH 
Sbjct: 198 DIIVGPGNKFVTEAKRQCYGQV---GIDFVAGPSEVLIIADETSNPVYIAADLLAQCEHD 254

Query: 264 PDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNA-SRLIVTKDLAQCVEISNQ 322
            +++ ILLT + ++A++V + +E  L +LP  + +  +      +I+  D+ + ++ISN 
Sbjct: 255 LNARGILLTNSLEVAQKVEKNIESMLKDLPTKDISYSSWENNGEIILVDDMEEAIKISNF 314

Query: 323 YGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLG 382
           Y PEHL +      ++ D +T+ GS+F+G+ S E  GDY SGTNH LPT   +     + 
Sbjct: 315 YAPEHLEVAVNEYNDICDRLTNYGSLFIGNLSAEVFGDYVSGTNHTLPTLKASRYTGGVW 374

Query: 383 LADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNA 429
           +  F K  T Q  +++   +LA   E LA  E L AH  A  +R   
Sbjct: 375 VGTFIKTCTKQIFNEKAIQSLAPVAEKLAKEEGLYAHAKAAEVRFKK 421


>UniRef50_Q46WL2 Histidinol dehydrogenase 1 n=202 Tax=Bacteria RepID=HISX1_RALEJ
          Length = 445

 Score =  531 bits (1370), Expect = e-149,   Method: Composition-based stats.
 Identities = 173/434 (39%), Positives = 243/434 (55%), Gaps = 14/434 (3%)

Query: 7   IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT---V 63
           +D +     Q  + ++       E+I R V  IL +VK RGD A+ EY+ +FD+     +
Sbjct: 14  LDSSDPRFAQALREVLAFEAGEDEAIDRAVAQILADVKDRGDAAVLEYTQRFDRVEAASM 73

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQK----LPPVDVETQPGVRCQQ 119
            AL++S  E+ AA E L  + + A+  A   +  +H  QK        +     G    Q
Sbjct: 74  GALEISQSELEAALEDLEPKRRAALEAAAARVRAYHEKQKIECGSHSWEYTEADGTMLGQ 133

Query: 120 VTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLC 176
              P+  VG+Y+PGG A   S+VLM A PA +AG K++++  P P     + +L AAQ+ 
Sbjct: 134 KVTPLDRVGIYVPGGKAAYPSSVLMNAIPARVAGVKEIIMVVPTPGGVRNELVLAAAQIA 193

Query: 177 GVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGP 236
           GV  VF +GGAQA+ ALA+GT ++P+VDKI GPGNA+V  AKR+V   +    IDM AGP
Sbjct: 194 GVDRVFTIGGAQAVGALAYGTATLPQVDKIVGPGNAYVAAAKRRVFGTV---GIDMIAGP 250

Query: 237 SEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAE 296
           SE+LVI D    PD+VA DL SQAEH   +Q ILL P AD   +V  +++RQL  +PR E
Sbjct: 251 SEILVICDGTTDPDWVAMDLFSQAEHDELAQSILLCPDADYIAQVEASIQRQLDSMPRRE 310

Query: 297 TARQALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSP 355
               +++    LI  +D+ +  EI+N   PEHL I   N R+  + I  AG++FLG ++ 
Sbjct: 311 VIAASISGRGALIKVRDMEEACEIANAIAPEHLEISAENPRQWSEKIRHAGAIFLGRYTS 370

Query: 356 ESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAER 415
           ES GDY +G NHVLPT       S LG+ DFQKR ++ E+S+ G   L      LA  E 
Sbjct: 371 ESLGDYCAGPNHVLPTSRTARFSSPLGVYDFQKRSSLIEVSEGGAQMLGQIAAELAYGEG 430

Query: 416 LTAHKNAVTLRVNA 429
           L AH  +   R   
Sbjct: 431 LQAHARSAEYRFKR 444


>UniRef50_Q5ZW87 Histidinol dehydrogenase n=6 Tax=Legionella RepID=HISX_LEGPH
          Length = 431

 Score =  530 bits (1366), Expect = e-149,   Method: Composition-based stats.
 Identities = 191/435 (43%), Positives = 277/435 (63%), Gaps = 9/435 (2%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
             TI +W   +   ++  L RP    S +I   V +I++ V+  GD+AL + + +FD+  
Sbjct: 1   MLTIKNWQLLSENDKKLCLSRPRQ--SSAIKENVLEIINQVQLSGDKALYDLTKQFDRVN 58

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
           +  L+V  E+I  A   +      A+  A+  I ++H +      ++ T  G+  + V R
Sbjct: 59  LQYLQVPQEKIEQA--NIPKNALNAITQAIGTISSYHQSLLPENTEISTASGITIRNVYR 116

Query: 123 PVASVGLYIPGG-SAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCG 177
           P+  VGLY+PGG   PL S++LM A PA +AGC   VLC+PP     I + IL AA+LCG
Sbjct: 117 PIQKVGLYVPGGNKTPLVSSLLMQAIPAKVAGCPIKVLCTPPDAEGEINEHILVAARLCG 176

Query: 178 VQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPS 237
           +  ++ +GGAQAIAA+A+GTESV KVDKIFGPGN++VT+AK  V+   DGAAIDMPAGPS
Sbjct: 177 IDTIYAIGGAQAIAAMAYGTESVIKVDKIFGPGNSYVTQAKTLVAIDADGAAIDMPAGPS 236

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAET 297
           EV+++AD+ A P+F+A+DLL+QAEHGPDSQVIL+    ++A +V + +E Q++ L R E 
Sbjct: 237 EVMILADTEANPEFIAADLLAQAEHGPDSQVILICDECELANQVNQQLEIQMSYLSRIEF 296

Query: 298 ARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPES 357
            +++L  SR+I+  + ++ ++I N Y PEHLII  +N    V+ I +AG+VFLG W+ E+
Sbjct: 297 IKRSLANSRIIICSNQSEQLDIINSYAPEHLIINRKNPEPWVEKIVAAGTVFLGSWAAET 356

Query: 358 AGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLT 417
            GDY +G+NHVLPT G+    S L   DF  R TVQ +++E    L     TLA  E L 
Sbjct: 357 MGDYVTGSNHVLPTSGFARNHSGLSTLDFMTRFTVQAINQEAIRNLGPAAMTLAELEGLD 416

Query: 418 AHKNAVTLRVNALKE 432
           AH NAV +R+N L +
Sbjct: 417 AHANAVQIRLNTLGD 431


>UniRef50_C7LV94 Histidinol dehydrogenase n=6 Tax=Desulfovibrionales
           RepID=C7LV94_DESBD
          Length = 436

 Score =  530 bits (1365), Expect = e-149,   Method: Composition-based stats.
 Identities = 159/435 (36%), Positives = 232/435 (53%), Gaps = 13/435 (2%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
              +++ S          M    +  +++   V DIL  V+ RGDEA+ EY+ +FD  ++
Sbjct: 3   LRFLEYTSPNDWTAIASWMARRDAGEDNVEPLVRDILAQVRERGDEAVAEYTRRFDCPSL 62

Query: 64  TA--LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVT 121
           +A  L V   +I  A E +  E    +  A  NI  FH  QK         PG    Q+ 
Sbjct: 63  SAAGLPVPKADIGRALELIPAEDAAIIREAAANIRDFHLRQKQNSWITTPAPGTTLGQLV 122

Query: 122 RPVASVGLYIPGGSA---PLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQ 174
            PV   GLY+PGG     PL S++LM A PA +AG   + + SPP     +   IL  A 
Sbjct: 123 LPVDRAGLYVPGGQGGETPLISSLLMNAIPAQVAGVGAICVVSPPRKDGTLNPYILATAA 182

Query: 175 LCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPA 234
           + G+  +F  G A AIAALA+GT S+P+VD I GPGN FVT AKR +  ++    IDM A
Sbjct: 183 ILGIDTIFMCGSAWAIAALAYGTASIPRVDVIAGPGNIFVTTAKRLLVGQV---GIDMIA 239

Query: 235 GPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPR 294
           GPSE+ ++ADS A P ++A+D+LSQAEH P +  IL++    +   V + + RQL  LPR
Sbjct: 240 GPSEIAILADSTANPKWLAADMLSQAEHDPLASSILISADQQLLEEVKKELARQLPALPR 299

Query: 295 AETARQAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDW 353
            E A ++L   S LI   DL   +++ N+  PEH  +   +   LV ++ +AG+VF+G  
Sbjct: 300 QEIASKSLSEWSALIHVPDLEMGMDLINRLAPEHFELSVADPWALVGAVRNAGAVFMGHS 359

Query: 354 SPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAA 413
           +PE  GDY +G NHVLPT       S+L +  F K+ ++    +   ++  S +  LA  
Sbjct: 360 TPEPVGDYFAGPNHVLPTLSTARFSSALSVDTFCKKTSLICTDQAYMNSHGSKVARLARL 419

Query: 414 ERLTAHKNAVTLRVN 428
           E L AH  +V  R+ 
Sbjct: 420 EGLEAHARSVEQRLE 434


>UniRef50_P62457 Histidinol dehydrogenase n=27 Tax=cellular organisms
           RepID=HISX_DESVH
          Length = 436

 Score =  529 bits (1364), Expect = e-149,   Method: Composition-based stats.
 Identities = 173/432 (40%), Positives = 239/432 (55%), Gaps = 13/432 (3%)

Query: 5   TIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVT 64
            I+   S         ++       +++   V DIL  V+++GDEAL EY+ +FD    T
Sbjct: 4   RILTLQSEAQWPLLGDMLAGRYDPDDAVEPVVRDILAAVRSKGDEALAEYTRRFDCPDFT 63

Query: 65  A--LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
              L V++EE+A A   +  +    +  A  NI +FH AQK     V    G    Q   
Sbjct: 64  PALLHVTSEEVAQAVASVPADDIAIIRQAADNIRSFHEAQKERSWFVTHDDGTILGQKVT 123

Query: 123 PVASVGLYIPGGSA---PLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQL 175
           PV   GLY+PGG     PL S++LM A PA +AG   + + SPP     +   +L AA +
Sbjct: 124 PVDRAGLYVPGGKGGDTPLLSSLLMNAIPAQVAGVTSITVASPPRPDGTLNPHLLAAAHI 183

Query: 176 CGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAG 235
            G+ D+   G A A+AA AFGT+++  VD I GPGN FVT AKR V  R+   AIDM AG
Sbjct: 184 LGITDIIRAGSAWAVAAFAFGTQTIAPVDVIAGPGNIFVTTAKRMVQGRV---AIDMIAG 240

Query: 236 PSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRA 295
           PSE+L++AD+ A PD+VA+D+LSQAEH P +  IL+T    +A  V   +ERQLA LPRA
Sbjct: 241 PSEILILADATARPDWVAADMLSQAEHDPLASSILVTTEPALAEAVTAELERQLATLPRA 300

Query: 296 ETARQAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWS 354
           + AR+AL +   ++V  D+   V I+N+  PEHL + T    EL  S+  AG++FLG +S
Sbjct: 301 DIARKALADWGAVVVVPDMDVAVAIANRVAPEHLEVLTAQPWELAGSLRHAGALFLGPYS 360

Query: 355 PESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAE 414
           PE  GDY +G NHVLPT G     S+L +  F KR ++   S+      A  +  LA  E
Sbjct: 361 PEPLGDYFAGPNHVLPTMGTARFSSALSVQTFCKRTSIIAASRAFAERNADAVARLARLE 420

Query: 415 RLTAHKNAVTLR 426
            L AH  +   R
Sbjct: 421 GLEAHARSAASR 432


>UniRef50_D1YWF4 Histidinol dehydrogenase n=1 Tax=Methanocella paludicola SANAE
           RepID=D1YWF4_METPS
          Length = 423

 Score =  528 bits (1362), Expect = e-148,   Method: Composition-based stats.
 Identities = 166/430 (38%), Positives = 236/430 (54%), Gaps = 13/430 (3%)

Query: 5   TIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVT 64
            I            ++  R    +S  +  T   + D V+  GD A+R+Y+ +FD   + 
Sbjct: 1   MIKQLYGVDDAALDEVFKRRTSISS--VMDTAKKVADEVREGGDAAVRKYTKQFDGVDLR 58

Query: 65  ALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPP--VDVETQPGVRCQQVTR 122
            L+V+ +E+  A E +  E    +  A+ NIE FH  Q+        E  PG+R  Q   
Sbjct: 59  DLEVTDDEMYNAVELIDYETIGHLEKAIDNIEAFHALQRPSGDMWLTEISPGIRLGQKFT 118

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGV 178
           P+  +G Y+PGG+    ST LML  PA +AG  +++ C+PP     I    L A  + G 
Sbjct: 119 PLERIGAYVPGGTGSYPSTALMLIVPAQVAGVSEIIACTPPRKDGTIHPLTLTALDMAGA 178

Query: 179 QDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSE 238
             +F VGG QAIAA+A+GT+S+PKV+KI GPGN +VT AK  V    D A IDMPAGPSE
Sbjct: 179 DRIFKVGGVQAIAAMAYGTQSIPKVEKIVGPGNIYVTAAKMYVR---DAAEIDMPAGPSE 235

Query: 239 VLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETA 298
           ++VIAD  A P F+ASD+++QAEH  ++  ILLTP+  +A  V   +ERQ    PR +  
Sbjct: 236 IVVIADDTAIPSFIASDMIAQAEHDVNAMSILLTPSEMLAESVELEIERQKENAPRRQII 295

Query: 299 RQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESA 358
            +A     + V  DL   VE+ N+  PEH+ I  R+    ++ + +AG+V++GD++P +A
Sbjct: 296 DKA--GMGIYVLDDLDAAVEVCNRIAPEHVEIMVRDPMSTLNKVRNAGTVYVGDYAPVAA 353

Query: 359 GDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTA 418
           GDYASG NHVLPT GY    S +    F K  +VQ + K G   +  TI  LA  E   A
Sbjct: 354 GDYASGANHVLPTGGYAKVFSGMNTMQFIKTTSVQVIEKGGLEGIKDTITALAEIEGFDA 413

Query: 419 HKNAVTLRVN 428
           H  +V  R  
Sbjct: 414 HARSVYKRFE 423


>UniRef50_Q4FQF8 Histidinol dehydrogenase n=6 Tax=Proteobacteria RepID=HISX_PSYA2
          Length = 431

 Score =  527 bits (1359), Expect = e-148,   Method: Composition-based stats.
 Identities = 171/431 (39%), Positives = 244/431 (56%), Gaps = 12/431 (2%)

Query: 7   IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKT---TV 63
           +       + Q   L+        ++  TV+DI+  V+  GD  + E + +FD+    T 
Sbjct: 4   LSTQDADFDSQLTELLAFETVNDATLLTTVDDIIARVRHGGDSVVLELTQQFDQHPATTT 63

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRP 123
            AL++S E +A A   L D +K A+  A   ++TFH  Q       E + G R  Q    
Sbjct: 64  QALELSKEALAEAFANLDDVVKSALITAATRVKTFHERQVQETWQYEDELGNRLGQKVTA 123

Query: 124 VASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCGVQD 180
           +  VG+Y+PGG A   S+VLM A PA +AG K+V++  P P   +   +L AA L  V  
Sbjct: 124 LDRVGIYVPGGLASYPSSVLMNAIPAKVAGVKEVIMVVPAPKGVLNPLVLAAAHLAKVDR 183

Query: 181 VFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVL 240
           VF +GGAQA+AALA+GTE++P VDKI GPGN +V  AKR V  ++    IDM AGPSEVL
Sbjct: 184 VFTIGGAQAVAALAYGTETIPAVDKITGPGNKYVAAAKRAVFGQV---GIDMIAGPSEVL 240

Query: 241 VIADSGA--TPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETA 298
           V A+  A    D++A DLLSQAEH   +Q I +T +A   + VA  +E+ LAELP+A+ A
Sbjct: 241 VYAEGEAQDRADWLAMDLLSQAEHDRIAQAIFVTTSAQQLKEVAIEIEKALAELPKADIA 300

Query: 299 RQALNA-SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPES 357
           R +L     LI+ +D  + + + N+  PEHL +   +   L++SI  AG++F+G  +PE+
Sbjct: 301 RDSLKNRGVLILVRDREEGMAVINRVAPEHLELSVDHPDALLNSIRHAGAIFMGRHTPEA 360

Query: 358 AGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLT 417
            GDY +G NHVLPT G     S LG+ DFQK+ ++   S+ G   LA T + LA  E L 
Sbjct: 361 IGDYCAGPNHVLPTSGTARFSSPLGVYDFQKKSSIIYCSESGSKPLAQTADILAQHEDLE 420

Query: 418 AHKNAVTLRVN 428
           AH  +   R  
Sbjct: 421 AHARSARYRYQ 431


>UniRef50_A9A0A6 Histidinol dehydrogenase n=2 Tax=Desulfobacteraceae
           RepID=A9A0A6_DESOH
          Length = 434

 Score =  523 bits (1348), Expect = e-147,   Method: Composition-based stats.
 Identities = 163/436 (37%), Positives = 248/436 (56%), Gaps = 13/436 (2%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
             I    +  A+++   ++   +  +      V  I+ +VK  GD+AL  Y+ +FD   +
Sbjct: 1   MKIYTSGTPEADRRLDRIINRGLDYTPEQLHQVAAIVADVKKNGDKALERYTRQFDAPKL 60

Query: 64  TA--LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVT 121
            A   +V+A E+A A++ +     +A+  A+  +  FH          E +PGV   +  
Sbjct: 61  AASGFRVTAAEMAGAAKEVDRSFVKAINRAIGQVSEFHAMGLEKTWTAEPRPGVVVGKKV 120

Query: 122 RPVASVGLYIPG---GSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQ 174
            PV S G+Y+PG   G  PL STVLM A PA  AG +++V+ +PP     +   +L AA+
Sbjct: 121 TPVDSAGIYVPGATGGRTPLVSTVLMGAIPAKTAGVRRIVMVTPPRQDGTVNPHLLVAAK 180

Query: 175 LCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPA 234
             GV +++ VG A AIAALA GT+++ +VD I GPGN +V  AK+ V+  +    IDM A
Sbjct: 181 KVGVHEIYKVGSAWAIAALAHGTKTIARVDMIAGPGNIYVALAKKIVAGTV---GIDMMA 237

Query: 235 GPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPR 294
           GPSE+LV+AD  A P ++A+DLLSQAEH   S  +L+T +  +AR V++ V+RQ   + R
Sbjct: 238 GPSEILVVADGSADPRYIAADLLSQAEHDALSAAVLVTTSMKVARAVSDEVKRQTTGISR 297

Query: 295 AETARQALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDW 353
            + AR+AL     + V K   +   + N++ PEHL + T+N  + +D I +AG+VFLG +
Sbjct: 298 WQIARKALAAYGAVFVVKSKKEAFALVNRFAPEHLELHTKNPEKDLDQIRNAGAVFLGPY 357

Query: 354 SPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAA 413
           +PE  GDY +G NH LPT G     S+L  A F KR ++   SK  F + A+ +  +AA 
Sbjct: 358 TPEPIGDYVAGPNHTLPTSGCARFASALSTAHFLKRTSIVSYSKAAFLSEAADVMRIAAV 417

Query: 414 ERLTAHKNAVTLRVNA 429
           E L AH NAV +R+  
Sbjct: 418 EGLDAHANAVGVRLEE 433


>UniRef50_Q9X0D1 Histidinol dehydrogenase n=6 Tax=Thermotogaceae RepID=HISX_THEMA
          Length = 428

 Score =  522 bits (1346), Expect = e-147,   Method: Composition-based stats.
 Identities = 154/430 (35%), Positives = 248/430 (57%), Gaps = 15/430 (3%)

Query: 10  NSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDK--TTVTALK 67
           N+   ++  +LL +   S S  +  TV +I+  VK  GD AL E+  +F+K    +  L+
Sbjct: 5   NNPGDKEVLRLLKQRMESVS-QVEETVKEIIRRVKEEGDRALEEFLKRFEKHPVGIENLR 63

Query: 68  VSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASV 127
           V+ +EI+ A  ++ +E  + + + +++++ FH  Q+       T+ G    ++  P+ SV
Sbjct: 64  VTEKEISEA--QVEEEFVETIKIVIEDLKEFHRRQEERSFFFTTKGGSFLGEMVVPLESV 121

Query: 128 GLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQDVFN 183
           G+Y+PGG  P FST+LM A PA +AG +++ + +PP     I+  IL   ++ G+++++ 
Sbjct: 122 GIYVPGGKVPYFSTLLMCAVPAIVAGVERIAVTTPPNENGGISPYILKTCEILGLKEIYR 181

Query: 184 VGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIA 243
           +GGA A+AAL +GTE+V  VDKI GPG  FVT AK+ V   +    ID  AGPSE+ ++ 
Sbjct: 182 MGGAHAVAALTYGTETVKPVDKIVGPGGVFVTLAKKHVYGDV---GIDSIAGPSEIAIVT 238

Query: 244 DSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELP--RAETARQA 301
           D  A  D +A+D LSQAEH  ++  +++T + ++  ++ + +ER L  LP  R +TAR +
Sbjct: 239 DGSADLDLIAADFLSQAEHDENAMSVVITTSKEVFEKLPQVIERHLEALPEERRKTARIS 298

Query: 302 LNA-SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGD 360
                 +I+T  L +  EISN   PEHL +   N  E +  I +AGSVFLG ++ ES GD
Sbjct: 299 TENFGTIILTDSLKRAFEISNLIAPEHLEVLVENPFEPLGHIKNAGSVFLGKYTCESVGD 358

Query: 361 YASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHK 420
           Y +G NHVLPT+      S L ++DF K++ +  LS+E F   +     +A  E   AH 
Sbjct: 359 YGAGPNHVLPTFRSARFSSGLRVSDFTKKIFITHLSEEDFRRKSELYSKMARWEGFEAHA 418

Query: 421 NAVTLRVNAL 430
            A+ +R   L
Sbjct: 419 RAIDVRREKL 428


>UniRef50_B9KYT3 Histidinol dehydrogenase n=1 Tax=Thermomicrobium roseum DSM 5159
           RepID=B9KYT3_THERP
          Length = 448

 Score =  521 bits (1342), Expect = e-146,   Method: Composition-based stats.
 Identities = 162/414 (39%), Positives = 238/414 (57%), Gaps = 9/414 (2%)

Query: 23  RPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSD 82
           R       +  + V  I+D+V+++GD+A+R Y+  FD   +     + EE   A   ++ 
Sbjct: 37  RAVFGGDLTPLQVVERIIDDVRSQGDDAVRRYTLAFDGAHLDTFLATPEEFLRARRAITP 96

Query: 83  ELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTV 142
           EL+ A+  A   I  FH            + G    Q+ RPV  VG+Y+PGG APL S++
Sbjct: 97  ELEAALRFARDRIVAFHRRAIPRSWIEFDETGAF-GQLVRPVDRVGIYVPGGRAPLPSSL 155

Query: 143 LMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQDVFNVGGAQAIAALAFGTE 198
           LM A PA +AG + +V+C+PP     I+  +L AA+L G++ VF +GGAQAIAALA+GT+
Sbjct: 156 LMTAIPAQLAGVRDIVVCTPPGRDGTISPAVLAAAELLGIERVFKIGGAQAIAALAYGTQ 215

Query: 199 SVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLS 258
           +VP VD + GPGN FV  AKR V   +    ID   GP+E L+IAD  A P   A+DLL+
Sbjct: 216 TVPAVDIVAGPGNLFVVLAKRLVYGDV---GIDQLPGPTETLLIADEQADPVLCAADLLA 272

Query: 259 QAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALN-ASRLIVTKDLAQCV 317
           QAEH P +  IL+TPA  +A +VA+ +ERQL +L R+E AR AL     +I+  DL +  
Sbjct: 273 QAEHDPLACAILITPARTLAHKVAQELERQLQQLDRSEIARAALEANGAIIIVPDLERAF 332

Query: 318 EISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTAT 377
           +++N + PEHL +  R+    +D +  AG VFLG+ SPE  GDY +G +HV+PT      
Sbjct: 333 DLANLFAPEHLCLLVRDPWRYLDRVRHAGGVFLGETSPEVIGDYTAGPSHVMPTGRTARF 392

Query: 378 CSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNALK 431
            S + +  F K  ++  ++ +    L S    LA +E LTAH  A+  R+   +
Sbjct: 393 ASPVTVQTFLKVTSLVAVAPKALEQLGSPALQLAMSEGLTAHAAAIEHRLERTR 446


>UniRef50_Q9P777 Histidinol dehydrogenase n=71 Tax=cellular organisms
           RepID=HISX_SCHPO
          Length = 439

 Score =  518 bits (1335), Expect = e-145,   Method: Composition-based stats.
 Identities = 193/427 (45%), Positives = 267/427 (62%), Gaps = 9/427 (2%)

Query: 7   IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTAL 66
               + TAE++ +LL RP  + ++ I   V  I+++VK+RG+ +L +Y++KF+K  + + 
Sbjct: 11  YRAAALTAEERTRLLARPIQN-TQKIRTIVQPIIEDVKSRGEASLIDYASKFEKVQLKS- 68

Query: 67  KVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVAS 126
            V          ++S  +K+ + +A  NI  FH++Q  P + V+T  GV CQ+++RP+  
Sbjct: 69  AVLKAPFDDDLMKISPMIKEDIDIAFNNIFAFHSSQLRPTIAVQTMRGVVCQRMSRPINR 128

Query: 127 VGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSP----PPIADEILYAAQLCGVQDVF 182
           VGLYIPGG+A L ST LML  PA +AGC  VV+ +P      +A EI+Y A   G + + 
Sbjct: 129 VGLYIPGGTAVLPSTALMLGVPAKVAGCPHVVISTPVRKDGTVAPEIVYIANKIGAEAII 188

Query: 183 NVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDG-AAIDMPAGPSEVLV 241
             GGAQAIAA+A+G   VPKV+KIFGPGN FVT AK  V        AID+PAGPSEVLV
Sbjct: 189 LAGGAQAIAAMAYGISGVPKVNKIFGPGNQFVTAAKMHVQNDYGALVAIDLPAGPSEVLV 248

Query: 242 IADSGATPDFVASDLLSQAEHGPDSQVILLTPA--ADMARRVAEAVERQLAELPRAETAR 299
           IAD    P+ VA DLLSQAEHG DSQ+ILLT +   +M  R+ +A+      L R+   +
Sbjct: 249 IADETCNPESVALDLLSQAEHGLDSQIILLTVSLSPEMFDRIQKAINDHALRLSRSYIIK 308

Query: 300 QALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAG 359
            A+  S ++   ++ Q  E SN YGPEHL++  +NA   +  I +AGSVF+G WSP S G
Sbjct: 309 HAIKKSVIVQVDNVDQAFEWSNLYGPEHLVLHLKNASSYIPKIDNAGSVFVGPWSPVSMG 368

Query: 360 DYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAH 419
           DYASGTNH LPTYGY ++ S +    F K +T QEL++EG   L  T+  LA  E LTAH
Sbjct: 369 DYASGTNHTLPTYGYASSYSGVSTDSFLKYITTQELTEEGIQRLGPTVIRLAELEGLTAH 428

Query: 420 KNAVTLR 426
            +AV +R
Sbjct: 429 ADAVRVR 435


>UniRef50_Q3B5E3 Histidinol dehydrogenase n=8 Tax=Chlorobiaceae RepID=HISX_PELLD
          Length = 443

 Score =  517 bits (1332), Expect = e-145,   Method: Composition-based stats.
 Identities = 152/434 (35%), Positives = 234/434 (53%), Gaps = 10/434 (2%)

Query: 1   MSFNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDK 60
           ++   +  +     +   + + R ++     + R V DIL+ V+ RGD A+ EY+ +F  
Sbjct: 14  VAVLKLYRFLD-DRDALFRQIGR-SVDFDPEVQRAVTDILEAVRLRGDMAVLEYTERFQG 71

Query: 61  TTVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQV 120
             +T+++V  E+I  A E       + +  A +NI  FH  +       E + GV   Q 
Sbjct: 72  AVLTSMQVPEEDILRAREEADPAFIRVLEEAWENILRFHRHEVENSFFYEGEGGVVLGQR 131

Query: 121 TRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSP----PPIADEILYAAQLC 176
             P+    LY+PGG A   S+VLM A PA +AG  ++ + +P      ++  IL AA + 
Sbjct: 132 VTPMDRAMLYVPGGKASYPSSVLMNAAPARVAGVGEIFMTTPCDASGAVSPHILAAASVA 191

Query: 177 GVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGP 236
           GV  V+ +GGAQA+AA A+GT+++PKVD I GPGN +V  AK+QV   +   AID  AGP
Sbjct: 192 GVTSVYRLGGAQAVAAFAYGTQTIPKVDIITGPGNKYVALAKKQVFGHV---AIDSIAGP 248

Query: 237 SEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAE 296
           SEV+V+AD  A  +F+  DL +QAEH PD+  +L+TP+  +A  V +    ++  + R E
Sbjct: 249 SEVVVVADDDADAEFITMDLFAQAEHDPDASSVLITPSMRLAEEVRDLAAARVGSMLRGE 308

Query: 297 TARQAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSP 355
              +AL N   ++V  D+ +   +S+   PEHL +   +  EL+ SI  AG+VF+G +S 
Sbjct: 309 VIAEALSNNGAIVVVADIEEACRVSDMIAPEHLELHVLHPWELLASIRHAGAVFMGGYSC 368

Query: 356 ESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAER 415
           E+ GDY +G NH LPT G     S L + DF K  ++   ++    A    I + A  E 
Sbjct: 369 ETVGDYYAGPNHTLPTNGTARFFSPLSVRDFVKHTSIISYTRRQIMACGERIASFADHEG 428

Query: 416 LTAHKNAVTLRVNA 429
           L AH  AV  R+  
Sbjct: 429 LEAHAEAVRARLKK 442


>UniRef50_Q4P7D9 Putative uncharacterized protein n=3 Tax=Eukaryota
           RepID=Q4P7D9_USTMA
          Length = 896

 Score =  515 bits (1327), Expect = e-144,   Method: Composition-based stats.
 Identities = 206/463 (44%), Positives = 276/463 (59%), Gaps = 36/463 (7%)

Query: 4   NTI--IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKT 61
             I    +   +A Q+++LL RPA+  +E +      IL +VK RGD AL E + KFDK 
Sbjct: 436 IKIQSYRYEDLSAAQRKELLKRPALR-TEQVMDICRPILRSVKERGDAALLELTEKFDKA 494

Query: 62  TVTA-LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLP--------------- 105
            +T  +++      +   ++  E+K A+ +A  NI  FH AQK                 
Sbjct: 495 KLTNAVRLPPFVDDSVMAQIKPEVKVAIDIAYNNIYKFHKAQKTTFGNKSAGATGSGSAD 554

Query: 106 --------PVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKV 157
                    ++VET PGV C++  RP+ SVGLY+PGGSA L ST LML  PA +A C  V
Sbjct: 555 GSEGAQDGVLEVETMPGVVCRRFARPIESVGLYVPGGSAVLPSTALMLGVPAQVARCPTV 614

Query: 158 VLCSPP----PIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAF 213
           V+ +PP     I+ E+LY A       +   GGAQA+AALA+GTES PKVDKI GPGN F
Sbjct: 615 VIATPPRADGSISPEVLYCASKVNASAILCAGGAQAVAALAYGTESCPKVDKIVGPGNQF 674

Query: 214 VTEAKRQVSQRLDG-AAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILL- 271
           VT AK  V    D   +IDMPAGPSEVLVIAD  A   FVASDLLSQAEHGPDSQV+L+ 
Sbjct: 675 VTAAKMLVQNETDAIVSIDMPAGPSEVLVIADREADAAFVASDLLSQAEHGPDSQVVLVG 734

Query: 272 --TPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQCVEISNQYGPEHLI 329
               ++++A  +   V+RQ   LPR +  RQA++ S  ++  D A  +E SN Y PEHLI
Sbjct: 735 IALSSSELA-AIEAEVDRQARALPRVDVVRQAIDKSVTVIVPDRATAMEWSNAYAPEHLI 793

Query: 330 IQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKR 389
           +QTR+A  LV+ + +AGS+F+G WSPES GDY SGTNH LPT  Y  + S + +A F+K 
Sbjct: 794 LQTRDAESLVECVQNAGSIFVGPWSPESCGDYMSGTNHSLPTAAYAKSYSGVNVATFEKC 853

Query: 390 MTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNALKE 432
           +T Q L+++G    A  +  LA  E L AH  AV +R++ ++ 
Sbjct: 854 ITSQSLTQQGLKGFAQNVIDLAMCEGLQAHAMAVKIRLDRIQS 896


>UniRef50_Q87C29 Histidinol dehydrogenase n=66 Tax=cellular organisms
           RepID=HISX_XYLFT
          Length = 431

 Score =  515 bits (1327), Expect = e-144,   Method: Composition-based stats.
 Identities = 216/428 (50%), Positives = 281/428 (65%), Gaps = 5/428 (1%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
             IIDWN      Q + L RPA + +      V  +++ V+  GD ALR+ +A+FD   +
Sbjct: 1   MKIIDWNQLDTAAQAKTLTRPAQTIATQTREAVTALIEQVRRGGDTALRDITARFDGVDL 60

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRP 123
              +V+A E+AAA+  ++ EL+ AM  A   IE FH A       VET PGV C+++ RP
Sbjct: 61  ATFEVTAAELAAAATAVAPELQHAMQTAAARIEAFHRAGMTNDYRVETAPGVVCERLVRP 120

Query: 124 VASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPI----ADEILYAAQLCGVQ 179
           +A VGLY+P GSAPLFST LML  PA +AGC++VVLC+PP         +L AA+L GV 
Sbjct: 121 IARVGLYVPAGSAPLFSTALMLGVPARLAGCREVVLCTPPSKDGRANPAVLLAARLTGVT 180

Query: 180 DVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEV 239
            VF +GGAQAIAA+A+GT SVP  DK+FGPGN+FVTEAK+Q++ +    AIDMPAGPSEV
Sbjct: 181 RVFTLGGAQAIAAMAYGTASVPTCDKVFGPGNSFVTEAKQQLA-QAGVVAIDMPAGPSEV 239

Query: 240 LVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETAR 299
           LVIAD+ A P F+A+DLLSQAEHGPDSQV+LL+ +  +   V  A+  QL +L RAE AR
Sbjct: 240 LVIADAAANPAFIAADLLSQAEHGPDSQVLLLSDSDALMTAVQNALALQLQQLSRAEIAR 299

Query: 300 QALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAG 359
           QAL  SR I    L    +ISN+Y PEHLI+  R  R  +  + +AGSVFLGD++PE+ G
Sbjct: 300 QALAHSRFIKVATLETAFDISNRYAPEHLILALRQPRAWLHRVAAAGSVFLGDYTPEALG 359

Query: 360 DYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAH 419
           DY SGTNHVLPT G     S + ++ FQ  ++VQ  S+ G + +     TLA AE L AH
Sbjct: 360 DYCSGTNHVLPTGGAARAYSGVSVSSFQNMISVQAASRSGIAEIGGCALTLARAEGLDAH 419

Query: 420 KNAVTLRV 427
            NAV LR+
Sbjct: 420 ANAVALRM 427


>UniRef50_Q3ZXL7 Histidinol dehydrogenase n=5 Tax=Dehalococcoides RepID=HISX_DEHSC
          Length = 436

 Score =  515 bits (1326), Expect = e-144,   Method: Composition-based stats.
 Identities = 158/422 (37%), Positives = 241/422 (57%), Gaps = 14/422 (3%)

Query: 12  CTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAE 71
               ++ +L  R  +       + VN I+ +V+ +GDEA+  Y+ KFD+  ++ L+V   
Sbjct: 24  LDETERTELARRLGVDP----EKAVNGIIADVRKQGDEAVLGYTLKFDRANLSKLEVGQP 79

Query: 72  EIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYI 131
           EI  A+  +  EL +A+ +A   I  +H  QK      +T   ++ +Q+ RP+  VGLY+
Sbjct: 80  EIQQAASEIPAELFEALQLAASQIRAYHRFQKEAVW--KTAEIMQGKQLIRPLERVGLYV 137

Query: 132 PGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQDVFNVGGA 187
           PGG A   STVLM A PA  AG K+++L +PP     I    L AAQ+ GV  +F  GGA
Sbjct: 138 PGGKAFYPSTVLMTAIPAREAGVKEIILVTPPGANGKIPAPTLAAAQIAGVDRIFACGGA 197

Query: 188 QAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGA 247
           QA+AALAFGT+S+PKVDKI GPGN FVT AK+ V   +D   ID   GPSEVL++AD  A
Sbjct: 198 QAVAALAFGTKSIPKVDKICGPGNIFVTLAKKAVFGVVD---IDGLQGPSEVLIVADQYA 254

Query: 248 TPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASR 306
             ++ ASD+L+QAEH   +  IL+T + D+A RV + VE +     R +  +Q+L +   
Sbjct: 255 NAEYCASDILAQAEHDALASSILITTSEDLANRVNDIVESKADTCSRRDIIKQSLRDNGL 314

Query: 307 LIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTN 366
           + V  ++ + ++++N Y  EHL +  +++ + +  I  AG +F G+ +    GDY +G +
Sbjct: 315 IAVVDNINEAIKLANMYAAEHLCLLVKDSEKYLTQINHAGCIFYGEKASVVMGDYVAGPS 374

Query: 367 HVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
           H LPT G     S L + DF K + + ++ K+  + L     T+A AE L  H  AV  R
Sbjct: 375 HALPTSGTARFSSPLNILDFVKYIDIVKVDKQDIAKLGQAAATIAKAEGLECHAEAVLKR 434

Query: 427 VN 428
           + 
Sbjct: 435 LE 436


>UniRef50_B3DXR9 Histidinol dehydrogenase n=1 Tax=Methylacidiphilum infernorum V4
           RepID=B3DXR9_METI4
          Length = 426

 Score =  513 bits (1321), Expect = e-144,   Method: Composition-based stats.
 Identities = 150/430 (34%), Positives = 251/430 (58%), Gaps = 8/430 (1%)

Query: 1   MSFNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDK 60
           M    I+ +     +Q+++ L R  +  S+ I +TV  +L+ +   GD+A+  Y+ +FDK
Sbjct: 3   MIDFKILRFGDLNWQQEKKGLSRFYL-PSKEIEQTVRRVLEEIIRNGDKAVSLYTEQFDK 61

Query: 61  TTVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQV 120
            +++     A  I   + +   ++  A+  A +NI  F  A K     +  + G R  + 
Sbjct: 62  QSISP---GAFRITEKAPQPPKDVVDALRWAKRNILCFAKANKPKNWSITNREGARVGEY 118

Query: 121 TRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQD 180
             P   +G+Y+PGG+APL ST LM    A  AG K++V+CSPPP+   + ++    G  +
Sbjct: 119 YTPFRRIGVYVPGGTAPLISTALMTVCFAKAAGVKEIVVCSPPPVNPILHFSIIYSGATE 178

Query: 181 VFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVL 240
           ++ +GG QAI ALA+GTES+PKV+KIFGPGNA+V EAKRQV   +   +ID+  GPSE+ 
Sbjct: 179 IYRIGGIQAIGALAYGTESIPKVEKIFGPGNAYVVEAKRQVIGPV---SIDLLPGPSEIA 235

Query: 241 VIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQ 300
           V A   A P+F+A+DLL+QAEHGP S+++ ++P   +   V  A+ RQL  L R +  ++
Sbjct: 236 VFASWPANPEFIAADLLAQAEHGPSSKILFVSPENSLLESVIGAINRQLPSLKRQQILKE 295

Query: 301 AL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAG 359
            L + +  +  + + + + + N + PEHL +Q   A++ +    + G+++LG +S  +AG
Sbjct: 296 VLTDHAYFVQVRSIDEGIGLINDFAPEHLSLQIPGAKKYLAQFKNCGAIYLGPYSAVAAG 355

Query: 360 DYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAH 419
           D+ +G +H LPT G   + S L ++ F ++ +V E SK+    ++S +ET A  E L AH
Sbjct: 356 DFLAGPSHTLPTGGAAKSFSGLTMSHFYRKTSVVEYSKKALCRVSSLLETFARIESLDAH 415

Query: 420 KNAVTLRVNA 429
             ++T+R  +
Sbjct: 416 GASITIRKES 425


>UniRef50_A5D1M4 Histidinol dehydrogenase n=1 Tax=Pelotomaculum thermopropionicum SI
           RepID=A5D1M4_PELTS
          Length = 437

 Score =  511 bits (1316), Expect = e-143,   Method: Composition-based stats.
 Identities = 153/440 (34%), Positives = 238/440 (54%), Gaps = 14/440 (3%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
           +  +      +AE   +++ R  +    S+   V  ++ +VK+RGD+AL +Y+ +FD  T
Sbjct: 2   YIQVFRLKEMSAEDYNRIMKRSEVETD-SVIGEVKKVIADVKSRGDDALVDYTREFDGIT 60

Query: 63  VT--ALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPP-VDVETQPGVRCQQ 119
           ++   ++VS EEI  A  ++  E  +A+     N+  FH AQ       +E  PG+   Q
Sbjct: 61  ISAEKIRVSPEEIKEAYHKVDRETVEAIKTLAGNVRRFHAAQMPNKMWSMEVSPGLVAGQ 120

Query: 120 VTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSP----PPIADEILYAAQL 175
           V  P+  VG Y+PGG     S V+M   PA +AG  +V++C+P      +    L A  +
Sbjct: 121 VIIPLDRVGCYVPGGRGWFPSAVMMSVLPARVAGVPEVIVCTPSAPDGSVPPGTLVACDI 180

Query: 176 CGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAG 235
           CG   VF +GG+QA+AA+A+GT++VPKVDKI GPG+ +V  A + +   ++   I   AG
Sbjct: 181 CGADAVFRIGGSQAVAAMAYGTQTVPKVDKIVGPGSKWVLAAFKLLYGEVE---IGTHAG 237

Query: 236 PSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELP-- 293
           P E L+IAD  A P+F A+D+  QAEHG DS  +L+T   ++A  V + + R +  L   
Sbjct: 238 PGEGLIIADETADPEFAAADICIQAEHGLDSAGVLVTHVEELAWAVQKKIARHIERLNEY 297

Query: 294 RAETARQALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGD 352
           R     ++L     +I+T  L + +  +N Y  EHL I TR+   ++  I +AG ++LG 
Sbjct: 298 RKNFVVESLKKYGAIIITSSLEESIAFANDYAVEHLEIMTRDPLHVMQKIKNAGGIYLGH 357

Query: 353 WSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAA 412
           ++P S G + SG NHVLPT         L  ADF K +T + LS+EG ++L   +  LA 
Sbjct: 358 YTPLSCGCFGSGPNHVLPTGRKAKVSGGLKTADFYKAVTFEYLSREGLASLKDAMVKLAE 417

Query: 413 AERLTAHKNAVTLRVNALKE 432
            E   AH NA+  R    + 
Sbjct: 418 YEGFPAHGNAILERFAREQS 437


>UniRef50_A3EUM9 Histidinol dehydrogenase n=3 Tax=Leptospirillum RepID=A3EUM9_9BACT
          Length = 445

 Score =  510 bits (1315), Expect = e-143,   Method: Composition-based stats.
 Identities = 156/422 (36%), Positives = 239/422 (56%), Gaps = 11/422 (2%)

Query: 20  LLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT--VTALKVSAEEIAAAS 77
           +  R   S  E++   V+ IL +++  GD AL  Y+ + D     +  L+VS   +  + 
Sbjct: 24  IFQRGRDSEGETLRARVSSILGDIRREGDVALLRYARELDGFRGELKDLRVSPGRMEESF 83

Query: 78  ERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAP 137
             L  E+++A+  A   IE FH A +   +        +   + RP+  VG+Y+PGG+A 
Sbjct: 84  GALPSEIRKALVFAKDRIEEFHGALREKGLSGLASRPGKGGVLVRPLHRVGVYVPGGTAA 143

Query: 138 LFSTVLMLATPASIAGCKKVVLCSP---PPIADEILYAAQLCGVQDVFNVGGAQAIAALA 194
             STVLM A  A +AG K++V  SP     I D IL A  +CGVQDV+ VGG  AIAA+A
Sbjct: 144 YPSTVLMTAVVAKVAGVKQIVGVSPAGPGGIPDAILAAFHVCGVQDVYQVGGVHAIAAMA 203

Query: 195 FGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVAS 254
           +GT ++P+VDKI GPGN +V EAKRQV   +D   IDM AGP+E+L++AD  A P+++A+
Sbjct: 204 YGTGTIPRVDKIVGPGNRYVAEAKRQVFGDVD---IDMVAGPTEILILADDSARPEWLAA 260

Query: 255 DLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDL 313
           D+++QAEH   +  +L+     +A+ V  A+ERQ++ LPR + A ++L     ++V   +
Sbjct: 261 DMIAQAEHDTRASAVLILTDMTLAKAVVLALERQISSLPRQKIAEESLLKYGFILVVPSV 320

Query: 314 AQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYG 373
              VEIS+   PEHL +Q RN  + +  I +AG+VFLG    E+ GDY  G +HVLPT G
Sbjct: 321 QVAVEISDLVAPEHLELQVRNPEKWLGLIQNAGAVFLGSEMAEAFGDYCFGPSHVLPTNG 380

Query: 374 YTATCSSLGLADFQKRMTVQE--LSKEGFSALASTIETLAAAERLTAHKNAVTLRVNALK 431
                S + +  F KR ++ E   S++    +      LA  E L  H  +   R+  ++
Sbjct: 381 SARFSSPVSIETFTKRTSLLEGFRSRQELEDVVRNSALLARLEGLEGHARSALARLENVQ 440

Query: 432 EQ 433
           ++
Sbjct: 441 KE 442


>UniRef50_C7NG13 Histidinol dehydrogenase n=2 Tax=Bacteria RepID=C7NG13_KYTSD
          Length = 439

 Score =  510 bits (1315), Expect = e-143,   Method: Composition-based stats.
 Identities = 218/435 (50%), Positives = 285/435 (65%), Gaps = 4/435 (0%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
             ++DWN+    ++   L RPA +  E +T  V ++LD V+ARG +A+  Y+ +FD    
Sbjct: 1   MRVLDWNALDDSERTAALERPAQAVGEQVTAAVAEVLDAVRARGADAVVGYTERFDGVGR 60

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRP 123
             L +S  EI  A E++ D ++ A+A A   + TFH    L P  V+T PG+RC+++ RP
Sbjct: 61  EHLLLSEAEIDRAVEQVPDAVRAAIAQAAATLRTFHAPGALSPFAVDTAPGMRCERIVRP 120

Query: 124 VASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPI----ADEILYAAQLCGVQ 179
           V +VGLY+P GSAPL ST LML  PA +AGC +VV+C+PP         ++ A    G++
Sbjct: 121 VRTVGLYVPAGSAPLPSTALMLGVPAVLAGCPEVVVCTPPTAQGTADPSVVAACVEVGIR 180

Query: 180 DVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEV 239
            +  VGGAQA+ A+AFG   +P+ DKIFGPGN+FVTEAKRQV+    G  ID+PAGPSE 
Sbjct: 181 RIAVVGGAQAVGAMAFGAGPIPRCDKIFGPGNSFVTEAKRQVAGMQGGPGIDLPAGPSEQ 240

Query: 240 LVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETAR 299
           LVIAD+GA P +VA+DLLSQAEHGPDSQV+ ++   D+  +VA  VERQ AELPRA+   
Sbjct: 241 LVIADAGANPVWVAADLLSQAEHGPDSQVVCVSDDRDLLEQVAAEVERQAAELPRAQIVA 300

Query: 300 QALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAG 359
            AL ASRL++  DL Q V +SN Y PEHLI+  R  REL+  IT+AGS+FLGD +PES G
Sbjct: 301 GALTASRLVLVDDLDQAVAVSNAYAPEHLILAVRAPRELLAGITAAGSIFLGDHTPESLG 360

Query: 360 DYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAH 419
           DY SGTNHVLPT G       + LA FQ  +TVQE S    + L +T  TLA AE L AH
Sbjct: 361 DYCSGTNHVLPTSGAARYTGGVNLASFQLSITVQEASPRALAQLGATAVTLARAEGLEAH 420

Query: 420 KNAVTLRVNALKEQA 434
             AVT RV+A +  A
Sbjct: 421 ARAVTRRVDASEAAA 435


>UniRef50_C8WUX6 Histidinol dehydrogenase n=2 Tax=Alicyclobacillus acidocaldarius
           RepID=C8WUX6_ALIAD
          Length = 426

 Score =  506 bits (1305), Expect = e-142,   Method: Composition-based stats.
 Identities = 171/430 (39%), Positives = 245/430 (56%), Gaps = 9/430 (2%)

Query: 7   IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTAL 66
           +  +     +Q     R        +   V  I++ V+  GD+ALR  +   D      L
Sbjct: 1   MRLDRVDVIEQASFNWRRTTGRDADVWEKVERIVEEVRVGGDDALRRLTRALDGVD-APL 59

Query: 67  KVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVAS 126
           +V  E + AA   L  E+++A+A A + I  FH AQ    + +  + G   + + RP+  
Sbjct: 60  RVPPEAMEAAFRALRAEVREALARAAERIRRFHEAQLPNDIVIRGEDGETLEMLWRPLHR 119

Query: 127 VGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPI----ADEILYAAQLCGVQDVF 182
           VG+Y PGG A   STVLM   PA +AG + + L SPP         +L AA L GV++++
Sbjct: 120 VGVYAPGGRAAYPSTVLMDVIPAQVAGVRSIALVSPPGPDGLPHPAVLAAAHLVGVEEMY 179

Query: 183 NVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVI 242
            VGGAQA+AALA+GTE++ +VDKI GPGN +V  AKR V   +    ID  AGP+EV+V+
Sbjct: 180 AVGGAQAVAALAYGTETIARVDKIVGPGNVYVATAKRMVMGDV---GIDSIAGPTEVVVV 236

Query: 243 ADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL 302
           AD  A P +VA+DLL+QAEH  ++  + L+P+ ++   V   + RQLA LPR + AR+AL
Sbjct: 237 ADETANPAYVAADLLAQAEHDVEAGAVCLSPSRELLENVHAEIVRQLAALPRRDIAREAL 296

Query: 303 N-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDY 361
                L+  K L   V + N   PEH+ + T N R +++ + +AG+VFLG ++PE  GDY
Sbjct: 297 ERHGALVHVKSLDDAVVLVNDMAPEHVEVVTENPRRVLNGLRTAGAVFLGPYTPEPVGDY 356

Query: 362 ASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKN 421
            +GTNHVLPT+G     S LG  DF +RMT    + E  +  A  IE LA AE LTAH+ 
Sbjct: 357 FAGTNHVLPTHGSARFSSGLGTLDFMRRMTAATYTAETIARHAPYIEALAEAESLTAHRE 416

Query: 422 AVTLRVNALK 431
           AV +R   L+
Sbjct: 417 AVRIRREELR 426


>UniRef50_P62460 Histidinol dehydrogenase n=15 Tax=Bacteria RepID=HISX_THET2
          Length = 412

 Score =  506 bits (1303), Expect = e-142,   Method: Composition-based stats.
 Identities = 172/414 (41%), Positives = 241/414 (58%), Gaps = 6/414 (1%)

Query: 14  AEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEI 73
           AE+ R    R  +S   ++   V  IL+ V+  GDEAL  +S   D   V   +V     
Sbjct: 5   AEEVRARFARRGLSFDPTVEEIVRGILEAVREEGDEALDRFSRDLDGYPVE--EVPKRAW 62

Query: 74  AAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPG 133
             A E L ++L+ A+  A + IE F+  +      +  + G    Q+ RP+  VG+Y+PG
Sbjct: 63  REAYEDLDEDLRDALETARERIEAFYREEARGGF-LRAEGGGVLAQLVRPLERVGVYVPG 121

Query: 134 GSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVFNVGGAQAIAAL 193
           GSAPL ST+LM   PA +AG ++V++ SPP +   +L AA + G   +F +GGAQAIAAL
Sbjct: 122 GSAPLLSTLLMTVVPAKVAGVREVIVASPPKVHPGVLAAAWVAGADRLFAMGGAQAIAAL 181

Query: 194 AFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVA 253
           A+GT  VP+VDKI GPGN +V  AKR V   +    ID  AGP+E ++IAD  A+P  +A
Sbjct: 182 AYGTGRVPRVDKIVGPGNRYVVAAKRLVYGTV---GIDGLAGPTETMIIADGSASPRLLA 238

Query: 254 SDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDL 313
           +DLL+QAEHGPDS+  LL+P   +  RV   + RQL +LPRAE ARQAL    L++TKDL
Sbjct: 239 ADLLAQAEHGPDSEPWLLSPDRALLERVEAELSRQLQDLPRAEVARQALEKGGLVLTKDL 298

Query: 314 AQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYG 373
            +   ++N Y PEHL +   +    ++ + +AG VFLG+ SPE+ GDY +G +HV+PT G
Sbjct: 299 EEAFALANLYAPEHLSLALSDPLPWLEKVQNAGGVFLGEGSPEALGDYIAGPSHVMPTSG 358

Query: 374 YTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRV 427
                  L + DF K + V  LS+     LA     LA AE L  H  ++ LR 
Sbjct: 359 TARFQGGLAVRDFLKVIPVVGLSEGAARELAKKGALLARAEGLEGHARSLDLRR 412


>UniRef50_Q4A044 Histidinol dehydrogenase n=62 Tax=Staphylococcus RepID=HISX_STAS1
          Length = 423

 Score =  501 bits (1291), Expect = e-140,   Method: Composition-based stats.
 Identities = 142/408 (34%), Positives = 234/408 (57%), Gaps = 11/408 (2%)

Query: 26  ISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELK 85
            S +E +   V DI +NV+  GD+ALR Y+ +FD+     L+V+ + +  A  RL  +L+
Sbjct: 16  SSLNEDLYPIVKDICENVRLHGDDALRNYNQQFDQVETCNLEVAYQTLENAYNRLDSDLR 75

Query: 86  QAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLML 145
           +A+  +   I+++  + K      + Q    C ++  P+  VG+Y+PGG A   STVLM 
Sbjct: 76  EALQQSHARIQSYQESIK----WTKQQGTSDCYELYHPLERVGVYVPGGKASYPSTVLMT 131

Query: 146 ATPASIAGCKKVVLCSPP---PIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPK 202
            T A +AG K + + +PP    I D +L A  + GV +V+ VGGAQ+IAALA+GTE++PK
Sbjct: 132 VTLAKVAGVKNISVVTPPQLNGIPDIVLAACYIAGVDNVYQVGGAQSIAALAYGTETLPK 191

Query: 203 VDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEH 262
           VDKI GPGN FV  AK+ +  ++    ID  AGPSE+ +I D  A  D +A D+ +QAEH
Sbjct: 192 VDKIVGPGNQFVAYAKKYLFGQV---GIDQIAGPSEIALIIDDSADLDAIAYDVFAQAEH 248

Query: 263 GPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVEISN 321
              ++  +++    + +++ + ++  L ++ R    + +L +   LI   + ++  ++ N
Sbjct: 249 DELARTFVISEDEALLKQLEQKIQHILPQIERQSIVQASLNDNHFLIHVNNFSEACDLMN 308

Query: 322 QYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSL 381
           Q  PEH  IQT +  + ++ +   G++FLG +SPE  GDY +G +HVLPT       + L
Sbjct: 309 QIAPEHASIQTVSPHDYLNHVRYVGALFLGYYSPEVIGDYVAGPSHVLPTNQTARFTNGL 368

Query: 382 GLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNA 429
            + DF  R +V +LSK+ F  +  T   LA  E+L  H+ ++ +R + 
Sbjct: 369 SVNDFLTRHSVIDLSKDTFDTVELTARKLAHVEQLYNHEQSIEIRTSK 416


>UniRef50_Q4FNE2 Histidinol dehydrogenase 1 n=3 Tax=Candidatus Pelagibacter
           RepID=HISX1_PELUB
          Length = 428

 Score =  501 bits (1291), Expect = e-140,   Method: Composition-based stats.
 Identities = 144/431 (33%), Positives = 244/431 (56%), Gaps = 8/431 (1%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              I+D  +   ++    L+    +  +  + +V  I+ +VK  GD+A+ +Y  +F+K +
Sbjct: 1   MIKILDSKNKNFDKTLDALLSKRKNKVQLNSVSVIKIIKDVKKNGDKAILKYEKRFNKNS 60

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
           +  +  S ++I  A + L  ++K+A+ +A   I  FH+ QK   +    +   + +    
Sbjct: 61  I--IAPSIKQINRAIQSLDQKVKKAIDLAYDRIYKFHSLQKFKNISYTDKLKNKLEYKYV 118

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPI---ADEILYAAQLCGVQ 179
           P+ SV +Y+PG +A   S+VLM A PA +AG K++V+ +P         +LYAA+ C ++
Sbjct: 119 PIESVAIYVPGSTASYPSSVLMNAVPAIVAGVKRLVMVNPGQKGKQNPAVLYAAKKCKIK 178

Query: 180 DVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEV 239
           +++++GG  AIAA+A+GT+ + KVDKI GPGN++V  AK++V   +      M AGPSEV
Sbjct: 179 EIYSIGGPSAIAAVAYGTKKIKKVDKIIGPGNSYVAAAKKEVFGDVGIEG--MIAGPSEV 236

Query: 240 LVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETAR 299
            ++ D  + P+++ASDL+ QAEH   +Q IL++    + ++V   +  QL ELPRA  A+
Sbjct: 237 TIVCDKFSNPEWIASDLIGQAEHDNLAQCILISKDKSIIKKVNYEIINQLKELPRAVIAK 296

Query: 300 QAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESA 358
            +L N   LI      + +   N+  PEHL + T+N +++V  I +AGS+ LG ++  + 
Sbjct: 297 NSLLNNGILIYMPSDQKIINTVNKIAPEHLELNTKNYKKVVSKIKNAGSICLGKYAVMAM 356

Query: 359 GDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTA 418
            DY  G+NHVLPT       S + + +F KR++   LSK+G   L  ++ TLA  E L  
Sbjct: 357 TDYNVGSNHVLPTNSSARYSSGVSVNEFYKRISYINLSKKGIETLGPSVITLANYEGLVG 416

Query: 419 HKNAVTLRVNA 429
           H  +V  R+  
Sbjct: 417 HAKSVEKRIRR 427


>UniRef50_C9RN89 Histidinol dehydrogenase n=1 Tax=Fibrobacter succinogenes subsp.
           succinogenes S85 RepID=C9RN89_FIBSS
          Length = 429

 Score =  500 bits (1289), Expect = e-140,   Method: Composition-based stats.
 Identities = 165/434 (38%), Positives = 241/434 (55%), Gaps = 15/434 (3%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
             I+     + ++  ++  R  ++ S+ I   V DIL ++K  G     EY+ KFD    
Sbjct: 1   MKIVKVTPKS-QEIDRICGR-EVAPSKEIHDKVMDILADIKNGGYAKAVEYAQKFDGLKG 58

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRP 123
             L+VS  EI  ++ +   E+++A+  A+KN+  FH  Q      +E + GV   Q  RP
Sbjct: 59  KNLRVSEAEIKKSAAKCPPEMQRALKQAIKNVRDFHVNQMEDSWLMEGKDGVVLGQRIRP 118

Query: 124 VASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSP--PPIADEILYAAQLCGVQDV 181
           +  VGLY+PGG+    STV+M A PA +AG K +V+ +P    I   + +     G+ +V
Sbjct: 119 MKRVGLYVPGGAGIYPSTVIMNAVPAIVAGVKDIVVVTPIKGEINRAVAFVLCELGITEV 178

Query: 182 FNVGGAQAIAALAFGTES------VPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAG 235
           +++GGAQAI  LA+G +       V +VDKI GPGN F   AK++V   +D   IDM AG
Sbjct: 179 YHIGGAQAIGMLAYGAKDGKGKVVVERVDKIVGPGNVFAAVAKKEVFGIVD---IDMVAG 235

Query: 236 PSEVLVIADSGATPDFVASDLLSQAEHGPD-SQVILLTPAADMARRVAEAVERQLAELPR 294
           PSEVLV+AD+   PDFVA+DLLSQAEHG      I +T   + A+ ++E V+ Q+   P+
Sbjct: 236 PSEVLVLADNTCDPDFVAADLLSQAEHGSGFEAAICITDNMETAQMISECVDIQVENSPK 295

Query: 295 AETARQALNA-SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDW 353
            E  ++ L+   R++V KD    V I+N   PEH+ I T  A  +   I +AG+VF+G W
Sbjct: 296 RELLQKVLDNFGRILVVKDWFDGVAIANAIAPEHMEIMTDEAESMAAQIENAGAVFIGPW 355

Query: 354 SPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAA 413
           S E  GDY +G NHVLPT G     S LG+ DF KRM++ + S++     A  I  +A  
Sbjct: 356 SSEPVGDYFAGPNHVLPTNGTGRFFSPLGVYDFLKRMSIIKYSEKAIKKNAKAIAVVANE 415

Query: 414 ERLTAHKNAVTLRV 427
           E    H  AV  R+
Sbjct: 416 EGFIHHAAAVLKRL 429


>UniRef50_D0LM64 Histidinol dehydrogenase n=2 Tax=Nannocystineae RepID=D0LM64_HALO1
          Length = 438

 Score =  500 bits (1289), Expect = e-140,   Method: Composition-based stats.
 Identities = 181/440 (41%), Positives = 256/440 (58%), Gaps = 12/440 (2%)

Query: 1   MSFNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDK 60
           M    I       + + R LL R + S +  + R V DIL  V+ARGDEA+R ++ KFD 
Sbjct: 1   MILKRIPLDAGGDSRELRALLER-STSFASEVERAVADILAEVRARGDEAVRAFTEKFDG 59

Query: 61  TTV---TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVE---TQPG 114
            +    ++ ++   +   A   L+ E+  A+  A + +  FH  Q       +      G
Sbjct: 60  RSPRAGSSYEIPPGDWRRAKGELAPEVLAALEQAAERVRAFHARQAEVDRAADFSLDGGG 119

Query: 115 VRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQ 174
           +R      P++ VG+Y+PGG+A   S+VLM A PA IAG  ++++ +P   + E L AA 
Sbjct: 120 MRLDLRIDPLSRVGIYVPGGTARYPSSVLMTAIPARIAGVDEIIMVTP-GASKETLAAAA 178

Query: 175 LCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPA 234
           L GV  VF +GGAQA+AALA+GTESVP+VDKI GPGN +V  AKRQV   +D   ID  A
Sbjct: 179 LAGVDRVFEIGGAQAVAALAYGTESVPRVDKIVGPGNQWVAAAKRQVFGVVD---IDSVA 235

Query: 235 GPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPR 294
           GPSEVL++AD  A P +VA+DLL+QAEH P +  +L T +  +A  V E + RQLA+LPR
Sbjct: 236 GPSEVLILADDSANPRWVAADLLAQAEHDPLAHPVLATTSPALADAVDEELARQLADLPR 295

Query: 295 AETARQALNA-SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDW 353
           A+ AR AL      ++  D    V  +N+Y PEHL +  R  R ++  + +AG++F+G  
Sbjct: 296 ADIARTALANQGAAVLVPDQGAAVAFANRYAPEHLELHLREPRAVLGQLRTAGAIFVGAL 355

Query: 354 SPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAA 413
           + E+AGDY +G NHVLPT G     S LG+ DF+K  ++ E   E   A A  I  LAA 
Sbjct: 356 AAEAAGDYMAGPNHVLPTGGAARYASPLGVYDFRKHTSIIEYQAEAVLAQADAIAALAAV 415

Query: 414 ERLTAHKNAVTLRVNALKEQ 433
           E L AH  ++TLR +AL+  
Sbjct: 416 EGLDAHGRSMTLRRDALRAA 435


>UniRef50_B1YL14 Histidinol dehydrogenase n=1 Tax=Exiguobacterium sibiricum 255-15
           RepID=B1YL14_EXIS2
          Length = 405

 Score =  499 bits (1285), Expect = e-139,   Method: Composition-based stats.
 Identities = 161/401 (40%), Positives = 235/401 (58%), Gaps = 6/401 (1%)

Query: 27  SASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQ 86
           S      + V  IL+ V   GD A+R Y+++FD+  +T  ++   +I  A ++    L  
Sbjct: 8   SVDRETEQAVRSILEQVANDGDAAVRRYTSEFDRVDLTDFRLDETKIQEAFDQADPNLVD 67

Query: 87  AMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLA 146
           ++ +    +  +H  +    +++     V  +Q   PV SVG+Y+PGG+A   STVLM A
Sbjct: 68  SLKLMATRLVEWHEQELPSDIELVEAD-VTRRQRFVPVDSVGIYVPGGAASYPSTVLMNA 126

Query: 147 TPASIAGCKKVVLCSP-PPIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDK 205
            PA +AG ++VV+ +P   ++ E+L AA++ GV +++ +GGAQA+AAL FGTES+  VD 
Sbjct: 127 IPAKVAGVERVVMVTPVTGLSMEVLVAAKIAGVTEIYTIGGAQAVAALTFGTESIQAVDL 186

Query: 206 IFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPD 265
           I GPGN FV EAKRQV   +    ID  AGPSEV+VIAD  A PD +A+DLL+QAEH  D
Sbjct: 187 IVGPGNRFVAEAKRQVYGIV---GIDSVAGPSEVVVIADETAHPDRIAADLLAQAEHDRD 243

Query: 266 SQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQCVEISNQYGP 325
           +  I   P   M   V   +ER+L +LPR E AR+A+    + V   L   +E +N+   
Sbjct: 244 AVAIAFVPTEAMKADVDANIERRLQQLPRQEIARRAMENGGVFVA-SLDDAIEEANRLAA 302

Query: 326 EHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLAD 385
           EHL +   N +E+V  I  AG +FLG  +PE+ GDY +GTNHVLPT G     S L    
Sbjct: 303 EHLELAVANPQEVVKLIRHAGMIFLGHETPETLGDYVAGTNHVLPTSGTARFASGLSART 362

Query: 386 FQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
           F +  T+ E ++EG + LA+  +T+A  E L AH  A+ +R
Sbjct: 363 FLRHQTMLEATREGVARLANAAKTVARVEGLEAHAQAIEVR 403


>UniRef50_Q01ZU1 Histidinol dehydrogenase n=1 Tax=Candidatus Solibacter usitatus
           Ellin6076 RepID=Q01ZU1_SOLUE
          Length = 423

 Score =  497 bits (1280), Expect = e-139,   Method: Composition-based stats.
 Identities = 168/428 (39%), Positives = 248/428 (57%), Gaps = 15/428 (3%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              I++           LL R A   +E+    V  IL+ V+ RGD AL +Y+ +FD+  
Sbjct: 1   MIRILESKDVG-----HLLKRKAARFTEA-EAVVTPILEAVRKRGDRALMDYARQFDQLQ 54

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
             +++V   E+ AA + L+ E + A+  A  NI  +   Q     +     G++  Q+ R
Sbjct: 55  RKSVRVPEGELLAARDGLTPEFRGAIETAAPNIRAYAGRQMPREWNRSFGAGLQLGQLVR 114

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVF 182
           P+ +V  YIP G  PL STV+M   PA +AG   + +  P P+A E+   A + GV++VF
Sbjct: 115 PLDAVAAYIPAGRYPLPSTVMMTVIPAQVAGVPNICIACPKPVA-EVYGTAAMLGVRNVF 173

Query: 183 NVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVI 242
            +GGAQAIAA AFGT +VP+ D+I GPGN +V  AK+ ++  +    ID  AGP+E+L+I
Sbjct: 174 QMGGAQAIAAFAFGTRTVPRADRIVGPGNIYVAAAKKLLAGEV---GIDFIAGPTEILII 230

Query: 243 ADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL 302
           A +   P   A+D+L+QAEH  D+  ILLT +  +A  V+  +ERQLA LP A  A +++
Sbjct: 231 A-ADGDPRHFAADMLAQAEHDVDASAILLTTSKRLAAAVSRELERQLAILPTAPVASKSI 289

Query: 303 -NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDY 361
              S +I+ + L + +EISN++ PEHL I       L+  +  AGSVF+G +SPE+AGDY
Sbjct: 290 AKNSAIILVRSLDEALEISNRFAPEHLSIPDA---SLLPGVRHAGSVFVGPYSPEAAGDY 346

Query: 362 ASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKN 421
           ASG NHVLPT G       L + D+ K ++VQ L++     LA +I TLA AE L AH  
Sbjct: 347 ASGPNHVLPTSGAARQRGGLSVTDYVKVISVQNLTEPALRRLAPSITTLARAEGLEAHAR 406

Query: 422 AVTLRVNA 429
           +V +R+  
Sbjct: 407 SVEVRLTR 414


>UniRef50_UPI00016BFCCC histidinol dehydrogenase n=1 Tax=Epulopiscium sp. 'N.t. morphotype
           B' RepID=UPI00016BFCCC
          Length = 419

 Score =  493 bits (1270), Expect = e-138,   Method: Composition-based stats.
 Identities = 172/431 (39%), Positives = 245/431 (56%), Gaps = 17/431 (3%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              I+D        +   +++ +   S  I R   +I++ VK  GD+AL +Y+ KFD+  
Sbjct: 1   MIKIVD--------KNTEILKHSAEISPQIERDAQEIVETVKRLGDQALFDYALKFDRAQ 52

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
           +T+L VS +E+  A E + D+L   +  A KNIE FH  Q      VE + G+   Q   
Sbjct: 53  LTSLLVSEQELKDAYEXIDDDLLGVIRRAKKNIEDFHKRQITNSFMVE-KDGIIMGQRVT 111

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGV 178
           P+  VG+YIPGG A   S+VLM   PA +AGC  + + +PP     +A EIL    + GV
Sbjct: 112 PIERVGIYIPGGXAVYPSSVLMNVIPAKLAGCSYISVVTPPREDGTVAKEILAICAMLGV 171

Query: 179 QDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSE 238
             VF +GGA AIAALA+GTESV  V KI GPGNA+V  AK+ V  ++    IDM AGPSE
Sbjct: 172 DQVFKIGGAGAIAALAYGTESVLPVYKITGPGNAYVAAAKKAVFGKV---GIDMIAGPSE 228

Query: 239 VLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETA 298
           +L+IAD    P  +A+D+LSQAEH   ++ ILLT + ++A  VA  +E QL++LP+ + A
Sbjct: 229 ILIIADEKQXPKIIAADMLSQAEHDMLARAILLTTSKEIAEEVATEIEIQLSKLPKEKIA 288

Query: 299 RQALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPES 357
           R +++    ++V   L++C  ISN   PEHL I   NA   +  I +AGSVFLG ++PE+
Sbjct: 289 RPSIDDNGLIVVCDTLSECFAISNDLAPEHLEIMLDNAISYLPEIKNAGSVFLGRYTPEA 348

Query: 358 AGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLT 417
            GDY +G NH LPT   +   S+L +  F K+ T  + ++E        I   A  E L 
Sbjct: 349 VGDYYAGVNHTLPTNQTSKFSSALSVDTFVKKSTFVQYTEEMLQKYKDDIVLFAKHEGLD 408

Query: 418 AHKNAVTLRVN 428
           AH  +V  R  
Sbjct: 409 AHARSVQSRFQ 419


>UniRef50_C4L171 Histidinol dehydrogenase n=1 Tax=Exiguobacterium sp. AT1b
           RepID=C4L171_EXISA
          Length = 405

 Score =  492 bits (1268), Expect = e-137,   Method: Composition-based stats.
 Identities = 148/405 (36%), Positives = 237/405 (58%), Gaps = 14/405 (3%)

Query: 30  ESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLS-DELKQAM 88
           E+    V  I+++++ARGDEAL +++ +FD       ++ + ++A+ +  ++  EL +A+
Sbjct: 11  EAWAEAVKPIVESIEARGDEALLKWTKQFDGVD----RIESVDLASFNPPVAYAELTEAL 66

Query: 89  AVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATP 148
           ++A + I TFH  Q       E     R  +   P+ SVG+Y+PGG+A   S+VLM   P
Sbjct: 67  SLAAERIRTFHARQVRQDDVFEDTM-FRLGRRYMPLDSVGVYVPGGTAVYPSSVLMNIIP 125

Query: 149 ASIAGCKKVVLCSPPP---IADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDK 205
           A +AG K+VV+ +PP    I   +L AA++ G  + F +GGAQA+AALA+GTE++  VDK
Sbjct: 126 AKVAGVKRVVMVTPPKADGIDISLLIAAKIAGADECFLIGGAQAVAALAYGTETIRPVDK 185

Query: 206 IFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPD 265
           I GPGNA+V  AK  VS  +    ID  AGPSEVL+IAD  A P +VA+DLL+QAEH  +
Sbjct: 186 IVGPGNAYVATAKALVSHIV---GIDSVAGPSEVLIIADETANPKWVAADLLAQAEHDVE 242

Query: 266 SQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQCVEISNQYGP 325
           +  I +  +  +  ++ + +ERQL +LPR + AR++L     ++ + +   +E +N    
Sbjct: 243 ATAIAIVTSETLRDQIEQELERQLVQLPRQDIARESLKRGG-VLYRTIEDAIEYANTMAA 301

Query: 326 EHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLAD 385
           EH+ +  ++   L+ +I   GS FLG  + E+ GDY +G NHVLPT G     S L + D
Sbjct: 302 EHVQLAVKDPEVLMRAIRHGGSFFLGHEAAEAFGDYIAGPNHVLPTSGTARFSSGLSVDD 361

Query: 386 FQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNAL 430
           F +R T  E+++     +      +A  E+L  H  A+ +R+  +
Sbjct: 362 FYRRQTFLEMTELD-ETITKAAIRIAKQEQLEGHARAMAVRMEDV 405


>UniRef50_Q5WIU9 Histidinol dehydrogenase 1 n=52 Tax=cellular organisms
           RepID=HISX1_BACSK
          Length = 424

 Score =  491 bits (1266), Expect = e-137,   Method: Composition-based stats.
 Identities = 147/412 (35%), Positives = 220/412 (53%), Gaps = 9/412 (2%)

Query: 27  SASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQ 86
            +   + +TV  ++  ++  G+ A+RE S +FD       ++SAEEI      + D++K 
Sbjct: 16  DSHGKVEQTVASLIARIEKEGETAVRELSRQFDNWDPEQFRLSAEEIEKIVRSVPDQVKA 75

Query: 87  AMAVAVKNIETFHTAQK--LPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLM 144
            +  A + I  F   Q+  +  ++VET+PGV       PV SVG YIPGG  P+ ++  M
Sbjct: 76  DICFAQEQIRHFAEQQRASIQDIEVETRPGVFLGHKNIPVNSVGCYIPGGRYPMVASSHM 135

Query: 145 LATPASIAGCKKVVLCSPP---PIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVP 201
               A +AG K+V+ C+PP    I    + A    G  +++ +GG QA+ A+A GTE++ 
Sbjct: 136 SILTAKVAGVKRVIGCTPPINGEIPAATVTAMHFAGADEIYILGGVQAMTAMAVGTETIE 195

Query: 202 KVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAE 261
            VD + GPGNAFV EAKRQ+  R+    ID+ AGP+EVL+IAD  A  + VA+DLL QAE
Sbjct: 196 AVDMLVGPGNAFVAEAKRQLFGRV---GIDLFAGPTEVLIIADDTADGEMVATDLLGQAE 252

Query: 262 HGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALN-ASRLIVTKDLAQCVEIS 320
           HGP S   L+T +  +A      +ERQL  LP A+ A+ A      +I+  DLA+ V  +
Sbjct: 253 HGPTSPAALITTSKKLAEETVAEIERQLQTLPTADVAKVAWEEHGMIILVDDLAEAVVEA 312

Query: 321 NQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSS 380
           ++   EH+ + T N    +D +T+ G++FLG  +  + GD   GTNH LPT         
Sbjct: 313 DKLAYEHVQVLTENPNYFLDHMTNYGALFLGPETNVAYGDKVIGTNHTLPTKKAAKYTGG 372

Query: 381 LGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNALKE 432
           L +  F K  T Q  + E  + +    E L   E    HK   +LRV    +
Sbjct: 373 LWVGKFLKNCTYQRCTPEASAEIGRIAERLCELEGFIGHKAQASLRVKRYGK 424


>UniRef50_Q67KH6 Histidinol dehydrogenase n=1 Tax=Symbiobacterium thermophilum
           RepID=HISX_SYMTH
          Length = 439

 Score =  491 bits (1265), Expect = e-137,   Method: Composition-based stats.
 Identities = 163/430 (37%), Positives = 234/430 (54%), Gaps = 12/430 (2%)

Query: 13  TAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA--LKVSA 70
             +   + L R        I   V  IL+ V+  GD AL  ++ +FD   + A  L+V+ 
Sbjct: 6   EPQAFLEFLNRRRTEFYPEIEAQVRAILERVRREGDGALYAFTRQFDGADLEATGLRVTE 65

Query: 71  EEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLY 130
            E   A   +S   + A+ VAV+NI  FH  Q           G    Q   PV   G+Y
Sbjct: 66  AEYREAEAAVSAAFRAALQVAVENIAAFHRPQVPTSWFTTRPDGTIVGQRVTPVDRAGVY 125

Query: 131 IPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQDVFNVGG 186
           +PGGSAPLFS +LM A PA +AG  +V++C+PP     I   +L AA+  GV+DV+ VGG
Sbjct: 126 VPGGSAPLFSCLLMTAIPAVVAGVPEVIVCTPPDRNGRIDPHMLVAARAAGVKDVYKVGG 185

Query: 187 AQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSG 246
           AQAI A+A+GT +VP+VDKI GPGN +VT AK+ V   +    IDM AGP+EV+ + D  
Sbjct: 186 AQAIGAMAYGTATVPRVDKIAGPGNYYVTLAKKLVFGPV---GIDMLAGPTEVMAVDDGS 242

Query: 247 ATPDFVASDLLSQAEHGPDSQVILLTPA-ADMARRVAEAVERQLAELPRAETARQAL-NA 304
              +++A+DLLSQAEH P+  VIL+T A  +    V  A+ R  A LPRAET R+++   
Sbjct: 243 VDAEWLAADLLSQAEH-PNGMVILVTTAGPERIAAVGAAMARHTAALPRAETIRRSVAEL 301

Query: 305 SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASG 364
              +    L +  ++ N  GPEHL +   +    +  +  AGS+FLG W+PE+ GDY +G
Sbjct: 302 GAALAVDTLEEAADLVNAVGPEHLEVGVADPWAFLPLVRHAGSIFLGRWTPEAMGDYIAG 361

Query: 365 TNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVT 424
            ++V+PT G     S + +  F KR  V   S+  F A A     LA  E L AH  ++ 
Sbjct: 362 PSNVIPTEGTARYASPVCVETFIKRSAVTCYSEAAFRAQAPHAVRLALTEDLLAHAASMQ 421

Query: 425 LRVNALKEQA 434
           +R+     ++
Sbjct: 422 IRLAKPDGES 431


>UniRef50_B1H0F0 Histidinol dehydrogenase n=1 Tax=uncultured Termite group 1
           bacterium phylotype Rs-D17 RepID=B1H0F0_UNCTG
          Length = 419

 Score =  489 bits (1260), Expect = e-137,   Method: Composition-based stats.
 Identities = 144/411 (35%), Positives = 236/411 (57%), Gaps = 22/411 (5%)

Query: 21  LMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA--LKVSAEEIAAASE 78
           +++     ++ I+  V+DI++++K  GDEA+ +Y  KFD   ++    +VS + I  A++
Sbjct: 9   IIKTNQMDAKQISIYVSDIIEDIKNNGDEAVFKYLKKFDNVDLSKKGYRVSQKVIDDAAK 68

Query: 79  RLSDELKQAMAVAVKNIETFHTAQKL--PPVDVETQPGVRCQQVTRPVASVGLYIPGGSA 136
           R+  +LK  +  +  NI  +H  ++          + G++  Q  RPV SVGLY+PGG  
Sbjct: 69  RIPKQLKNVIKSSYSNILAYHKYERSQIKKRWNYVKNGLKIGQFYRPVESVGLYVPGGRF 128

Query: 137 PLFSTVLMLATPASIAGCKKVVLCSPPP-IADEILYAAQLCGVQDVFNVGGAQAIAALAF 195
           P  STV+M A PA  AG K++V+ +PP  + D +L++A+LCG+++++ +GG  A+ ALA+
Sbjct: 129 PYPSTVIMTAVPAMAAGVKRIVMVTPPKNMNDAVLFSAKLCGIKEIYCIGGVMAVGALAY 188

Query: 196 GTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASD 255
           GT+++ KVD I GPGNA+V EAK+QV  R+    ID  AGP+EV +IAD     D+V +D
Sbjct: 189 GTKTLKKVDMIVGPGNAYVNEAKKQVFGRV---GIDSLAGPTEVAIIADKDVPTDYVVAD 245

Query: 256 LLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQ 315
           +++Q EH P ++  LL  +A     + + + ++  +  R E                L +
Sbjct: 246 VMAQVEHDPLAKTYLLCESAKKMSEIEKLLPKEALKQLRTELC-------------SLNK 292

Query: 316 CVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYT 375
            V+I N   PEHL +  +N + L+ ++ +AG+VF+G  +P ++GDY +G +HVLPT G  
Sbjct: 293 AVDIVNNIAPEHLELLVKNYQILLKNVRNAGAVFVGYQTPTASGDYWAGPSHVLPTNGSA 352

Query: 376 ATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
              S L +  F KR    E++K    A   TI   A AE +  HK +  +R
Sbjct: 353 KFSSGLSVMTFLKRSAYIEMNKNNKKAYK-TIADFAQAENMQYHKKSAEVR 402


>UniRef50_D1N997 Histidinol dehydrogenase n=2 Tax=Lentisphaerae RepID=D1N997_9BACT
          Length = 431

 Score =  487 bits (1255), Expect = e-136,   Method: Composition-based stats.
 Identities = 170/436 (38%), Positives = 239/436 (54%), Gaps = 13/436 (2%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              +   ++      ++L  RP  S    I      I+ +VKA GD AL  Y+AKFD   
Sbjct: 1   MKKLYFGSADFEADLKKLYDRP--SYPPEIEAQAAAIIADVKAEGDAALVRYAAKFDHAE 58

Query: 63  VTA--LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQV 120
           +T    +V+ +EIAAA ++L   LK A+  A++ +  F             +PGV   + 
Sbjct: 59  LTPAQFRVTGDEIAAAEKQLPARLKSAIRTALRQVRDFAKLTIPKGWTASPRPGVTLGEK 118

Query: 121 TRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLC 176
             P+  VG+YIPGG+APL STVL  A  A  A  K++V  +PP     +   +LYA +L 
Sbjct: 119 FEPLDRVGVYIPGGTAPLVSTVLHTAGIAGAAKVKEIVAVTPPGRDGKVHPAVLYAMKLA 178

Query: 177 GVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGP 236
           GV +++ +GG   +AALA GTE++ KV+KI GPGNA+VT AK+ +  ++   AIDM AGP
Sbjct: 179 GVTEIYRLGGVYGVAALACGTETIAKVEKIVGPGNAYVTAAKKLLYGQV---AIDMVAGP 235

Query: 237 SEVLVIADSGATPDFVASDLLSQAEHGPD-SQVILLTPAADMARRVAEAVERQLAELPRA 295
           SE+LVIAD  A P F+A+DLLSQAEHG    Q +L+T    M  RV     RQ A LPR 
Sbjct: 236 SEILVIADETADPSFIAADLLSQAEHGSGLEQAVLVTTDKAMIDRVEAEFLRQKATLPRL 295

Query: 296 ETARQALNAS-RLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWS 354
            T  +       LI T DL     I++ Y PEHL IQT    ++   IT+AG++FLG W+
Sbjct: 296 ATVDRVQEHGLFLIHTPDLDTAAAIASSYAPEHLEIQTARPEQVARKITAAGAMFLGKWT 355

Query: 355 PESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAE 414
           PE  GD+ +G +HVLPT       + L    F +R ++ + ++       S +E  A  E
Sbjct: 356 PEPVGDFCAGPSHVLPTASSARYFNGLETVSFFRRSSIVKYTEAAIRREVSMVEAFAEME 415

Query: 415 RLTAHKNAVTLRVNAL 430
            L AH  + T+RV  L
Sbjct: 416 GLAAHGRSGTIRVKPL 431


>UniRef50_Q7UX39 Histidinol dehydrogenase n=6 Tax=Planctomycetaceae RepID=HISX_RHOBA
          Length = 460

 Score =  486 bits (1252), Expect = e-136,   Method: Composition-based stats.
 Identities = 152/402 (37%), Positives = 225/402 (55%), Gaps = 11/402 (2%)

Query: 34  RTVNDILDNVKARGDEALREYSAKFDKTTV--TALKVSAEEIAAASERLSDELKQAMAVA 91
             V  I  +V+++G EAL  Y+   D   +    L+V  E++ AA      +L + +   
Sbjct: 63  EVVETICKDVQSQGTEALLRYTKSLDGAELTADTLRVPEEDLKAAHAVADPKLIETIGRI 122

Query: 92  VKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASI 151
             NI TF +A     V +  +PGV   Q   P+  VG+ +PGG+A   STV+M A PA +
Sbjct: 123 RDNIATFQSAILHRDVTITPRPGVSLTQRYVPIPRVGICVPGGAAAYPSTVMMTAIPAQV 182

Query: 152 AGCKKVVLCSPPPI----ADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIF 207
           AG  ++ + +PP        ++L      G+++V+  GGAQA+AA+A+G +++P VDKI 
Sbjct: 183 AGVDEIAVVAPPTPFGAYNTDMLATCHELGIKEVYRCGGAQAVAAMAYGCDALPAVDKIV 242

Query: 208 GPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQ 267
           GPGN FV  AK+ V   +D   ID  AGPSEV+VIAD  A   FVASDLL+QAEH P S 
Sbjct: 243 GPGNLFVALAKKHVFGTVD---IDSFAGPSEVIVIADESANAAFVASDLLAQAEHSPGS- 298

Query: 268 VILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVEISNQYGPE 326
            IL+T    +   V   + RQL EL R + AR AL +   L++ +D     E+++ + PE
Sbjct: 299 AILITWDESLLTSVQAELSRQLGELERGDLARDALSDFGALVLARDADHACELTDSFAPE 358

Query: 327 HLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADF 386
           HL I+TR    L+  I  +G+ FLG  +P + GDYA+G +HVLPT G     + L    F
Sbjct: 359 HLQIETREPESLIAKIRHSGAAFLGHHTPVALGDYAAGPSHVLPTGGTCRWAAGLSANSF 418

Query: 387 QKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVN 428
            +  +V +  +   SA+A  + T+A  E LTAH  ++++R  
Sbjct: 419 LRSGSVTQFDQSALSAIAQDVITVAEKEGLTAHARSISIRTE 460


>UniRef50_A6UA68 Histidinol dehydrogenase n=4 Tax=Proteobacteria RepID=A6UA68_SINMW
          Length = 432

 Score =  486 bits (1251), Expect = e-136,   Method: Composition-based stats.
 Identities = 155/409 (37%), Positives = 223/409 (54%), Gaps = 6/409 (1%)

Query: 23  RPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSD 82
           R A+S +  + +TV +I+ NV+ RGD A+REYSA FDK  +   +VS EE   A   L  
Sbjct: 20  RDAVSDTAPVEKTVKEIIANVRERGDAAVREYSAAFDKVELEKFEVSQEERLKAVAELDP 79

Query: 83  ELKQAMAVAVKNIETFHTAQKLP--PVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFS 140
           + ++    A+ N+  F  AQ     P+++ET PG+       P+  VG Y+PGG  PL S
Sbjct: 80  QTREDTEFAIANVRAFAEAQLKTILPLEIETLPGLHLGHRVIPIEIVGCYVPGGRYPLLS 139

Query: 141 TVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESV 200
             +M   PA +AGC +V+ C PP     ++    L G   +F VGGAQAIAA+A GTE++
Sbjct: 140 APVMTIVPAKVAGCDQVIACLPPNAHPAMIAGCHLSGADRIFRVGGAQAIAAMASGTETI 199

Query: 201 PKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQA 260
           P VDKI GPGNAFV EAKRQV  ++    ID  AGPSE+ ++AD       +A+DLL+QA
Sbjct: 200 PAVDKIVGPGNAFVNEAKRQVFGQV---GIDQLAGPSEIFIVADETGKAAMIATDLLAQA 256

Query: 261 EHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVEI 319
           EH   ++V L+T    +A      VE+QL +L  A  A  A  +   + V +D    +  
Sbjct: 257 EHDVRTRVGLITTDRKLAEETLVEVEKQLQDLSTANVASVAWKDYGEITVCEDETTMIAY 316

Query: 320 SNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCS 379
           S+    EHL + TR+ +     + + GS+F+G+ +     D   GTNH LPT        
Sbjct: 317 SDYIAAEHLQVHTRDPQATARKLRNYGSLFIGELASVVYSDKCCGTNHTLPTMAAGRYTG 376

Query: 380 SLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVN 428
            L +  + K  T Q L + G +A+A      +A ERL  H+ A  LR++
Sbjct: 377 GLWVGSYLKTCTHQWLDERGVAAVAPAAVRQSATERLEGHRRAAALRLS 425


>UniRef50_Q8TXG3 Histidinol dehydrogenase n=1 Tax=Methanopyrus kandleri
           RepID=HISX_METKA
          Length = 431

 Score =  485 bits (1249), Expect = e-135,   Method: Composition-based stats.
 Identities = 168/408 (41%), Positives = 230/408 (56%), Gaps = 11/408 (2%)

Query: 31  SITRTVNDILDNVKARGDEALREYSAKFDKTTVT--ALKVSAEEIAAASERLSDELKQAM 88
            +   V  I ++V  RGDEAL EY+ +FD   +    L+VS ++   A E + +   +A+
Sbjct: 25  EVLPDVERIFEDVVERGDEALLEYTERFDGVKLEAEDLRVSEDDFEVARELVDERTVEAL 84

Query: 89  AVAVKNIETFHTAQKLP-PVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLAT 147
             A   IE FH               G  C    RP+  VG Y+PGG A   ST LM   
Sbjct: 85  EEAAHRIEEFHRKTLPRVDRITFDVEGTECGLTLRPIPRVGCYVPGGRAAYPSTALMTVI 144

Query: 148 PASIAGCKKVVLCSPP-----PIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPK 202
           PA +AGC++VV+C+PP       + E+L A ++ G   V+ VGGAQAIAALA GTE+V +
Sbjct: 145 PARVAGCREVVVCTPPADNDVRASPEVLVAVEIAGADAVYRVGGAQAIAALAAGTETVLR 204

Query: 203 VDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEH 262
           VDKI GPGN +VT AK     R     +DMPAGPSEV VIAD  A PD++A DL++QAEH
Sbjct: 205 VDKIVGPGNVYVTAAKLLAYSR-GLTDVDMPAGPSEVFVIADDSANPDWLARDLIAQAEH 263

Query: 263 GPDSQVILLTPAADMARRVAEAVERQL-AELPRAETARQALN-ASRLIVTKDLAQCVEIS 320
            P +  +L T + ++AR V E VE  L A + R E   +AL+    ++V   L +CV ++
Sbjct: 264 DPHAAAVLATDSEEIARAVKERVEELLDAGIEREEIVLKALDRNGWIVVLDSLEECVRLA 323

Query: 321 NQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSS 380
           N+Y PEHL +   N  EL+  + +AG+VF+G  +    GDYA+G NHVLPT G+     +
Sbjct: 324 NRYAPEHLQLCVENPEELLQDVENAGAVFVGHLTAVPFGDYATGPNHVLPTGGFARARGA 383

Query: 381 LGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVN 428
           LG  DF K + +Q L +     LA  +E LA  E L  H  AV  R +
Sbjct: 384 LGTWDFVKIIPIQRLREGDVERLAPIVEELAEREGLPNHAEAVRARRS 431


>UniRef50_Q483H8 Histidinol dehydrogenase 2 n=15 Tax=Proteobacteria
           RepID=HISX2_COLP3
          Length = 446

 Score =  485 bits (1248), Expect = e-135,   Method: Composition-based stats.
 Identities = 150/442 (33%), Positives = 231/442 (52%), Gaps = 16/442 (3%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDK--T 61
             I   +  +AEQ+ +LL R   +    I   V  I++NVK  GD+AL EY+ KFDK   
Sbjct: 5   VKIHRLSDLSAEQRNKLLQRTESNLDNFI-DIVKPIIENVKLNGDKALSEYAKKFDKAEV 63

Query: 62  TVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPP-VDVETQPGVRCQQV 120
           +   ++V+  E   A   + +E+ Q ++ ++ NI+ FH AQ        + +PG      
Sbjct: 64  STDQIQVTQAEFDEAFTLVDEEVIQTLSYSIDNIKKFHEAQMPEEMWMKQIRPGCYAGDR 123

Query: 121 TRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLC 176
             P+ +V  YIP G     S  +M A PA +AG    ++ +PP     +    L  A+L 
Sbjct: 124 FTPINAVACYIPRGKGSFPSVAIMTAVPAIVAGVPTAIIITPPGTDGKVDAATLVVAKLV 183

Query: 177 GVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGP 236
           G+  VF  GGAQ IAA+A+GT +VPK DK+ GPG+ FV  AK+ ++  +       PAGP
Sbjct: 184 GIDKVFKCGGAQGIAAVAYGTNTVPKCDKVVGPGSPFVVAAKKLLADIIHPGT---PAGP 240

Query: 237 SEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPR-- 294
           SE +V+AD  A P   A DLL +AEHGPDS   L+T + ++A +   A+      + R  
Sbjct: 241 SEAIVLADDTANPKLAALDLLVEAEHGPDSSAFLVTNSKELAEQAQVAINEYWQHMDRLR 300

Query: 295 AETARQAL--NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGD 352
            + +   L  +   +++T    + V+  N Y  EHL+I +++  + +  I +AG + LG+
Sbjct: 301 VDFSSTVLSGDNGGIVLTSTFEEAVDFCNDYAAEHLLILSKSPFDHLGKIINAGEILLGE 360

Query: 353 WSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAA 412
            +P S  +Y  G N VLPT     T S L + D+ K  ++  L++EG+  LA      A 
Sbjct: 361 NTPISIANYTLGPNAVLPTSMAAKTASPLSVFDYLKSCSIGYLTREGYEELAPHTYRFAK 420

Query: 413 AERLTAHKNAVT-LRVNALKEQ 433
            E   AH NAV+ LR  A+K +
Sbjct: 421 YEGFDAHANAVSHLRDEAIKSE 442


>UniRef50_A1ZJE8 Histidinol dehydrogenase n=1 Tax=Microscilla marina ATCC 23134
           RepID=A1ZJE8_9SPHI
          Length = 429

 Score =  483 bits (1245), Expect = e-135,   Method: Composition-based stats.
 Identities = 171/435 (39%), Positives = 262/435 (60%), Gaps = 12/435 (2%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              II       E   +L  R      E++ + V  IL  V+  GD+ALR +  K+D+  
Sbjct: 1   MEKIIY---PHKEDWSKLQERT-FETYEALEKAVRPILRRVQREGDKALRSFVFKYDRVR 56

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
           +   +++ EE+A AS  +SDELK+A+ VA  NI TFH  Q      +ET  GV   Q   
Sbjct: 57  IKRFQLTPEELAEASNHVSDELKEAINVAKYNIATFHLTQTKAVKKIETTEGVFSWQKNV 116

Query: 123 PVASVGLYIPG-GSAPLFSTVLMLATPASIAGCKKVVLCS----PPPIADEILYAAQLCG 177
           P+A VGLY+P  G APL+S +LM+   A+IAGCK+++LCS       I   ILY A L  
Sbjct: 117 PIAKVGLYVPSTGDAPLYSHILMMGILANIAGCKEIILCSAANHEGRIHPIILYTAHLLN 176

Query: 178 VQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPS 237
           ++ V+ VGG QAIAA+A+GTE++PKVDKIFGP N +V+ AK+ VS+  +  AIDMP GPS
Sbjct: 177 IKKVYRVGGVQAIAAMAYGTETIPKVDKIFGPSNEYVSTAKQLVSK--NDVAIDMPVGPS 234

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELP-RAE 296
           E+  +AD    P + A+D+L+ AE    +Q+++LT A ++A ++   V++QL ELP + E
Sbjct: 235 ELCYVADQSTNPVYAAADILAHAEQSSHNQLVVLTNAEEVADKIQAEVDKQLNELPLKKE 294

Query: 297 TARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPE 356
            A++    +++IV K   + +  +N+Y PE+L++   NA  + D IT+A S+ LG  +P 
Sbjct: 295 VAKEVFKNAKIIVFKSNVESIAFANEYAPENLVLAIDNAEAVGDRITNASSIHLGHLTPP 354

Query: 357 SAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERL 416
           + G YA+G NH+LP+ G+  + S L +  F K++  Q+++  G   + ST+ T++ AE L
Sbjct: 355 AVGYYAAGPNHILPSNGFARSYSGLSVDSFVKKINFQQVTPLGLQNVGSTVATMSEAEEL 414

Query: 417 TAHKNAVTLRVNALK 431
              KN++  R+  L 
Sbjct: 415 LGRKNSIIKRLELLD 429


>UniRef50_UPI00017455E1 Histidinol dehydrogenase n=1 Tax=Verrucomicrobium spinosum DSM 4136
           RepID=UPI00017455E1
          Length = 428

 Score =  482 bits (1241), Expect = e-134,   Method: Composition-based stats.
 Identities = 158/430 (36%), Positives = 240/430 (55%), Gaps = 11/430 (2%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
             I+ +           L R A + S+ +   V  ++ +++  GD+AL E + KFD  T+
Sbjct: 1   MRILRYTDAAYADALCRLNRRAEA-SDRVRDVVAAVIADIRQNGDKALLELTQKFDGATL 59

Query: 64  --TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVT 121
               L VS EE+AAA   L+ E++ A+  +++N+ TF          +  + G    +V 
Sbjct: 60  TAEQLVVSTEEVAAAVASLTPEVRAALDASLRNVTTFAHQSLRKDWSMINEQGAEVGEVY 119

Query: 122 RPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLC----G 177
            P   VG+Y+PGG+APL ST +M    A+ AG  ++V+CSP     ++           G
Sbjct: 120 HPFERVGVYVPGGTAPLVSTAIMTVAIAAAAGVPEIVVCSPCGKDGKVNANLLAALSLAG 179

Query: 178 VQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPS 237
             +++ VGG+QAIAA+AFGTE++  V KIFGPGN++V EAKRQV   +   ++D+  GPS
Sbjct: 180 ATEIYRVGGSQAIAAMAFGTETIKPVTKIFGPGNSYVVEAKRQVFGVV---SVDLLPGPS 236

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAET 297
           EV+V+ADS A P F+A+DLL+QAEHG DS V  LT    +   V   VE Q  +L R E 
Sbjct: 237 EVMVLADSSANPAFIAADLLAQAEHGKDSGVAFLTDDETLLNAVVSQVETQGQKLTRQEM 296

Query: 298 ARQALNAS-RLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPE 356
            R  L+    L++   L +  EI N Y PEHL + T    +++  I +AG++FLG++SP 
Sbjct: 297 VRSVLDKECFLMLVPTLEEGAEIVNNYAPEHLSLITAREHDILPLIRTAGAIFLGNYSPV 356

Query: 357 SAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERL 416
           + GD+ +G +H LPT G   +   L +  FQKR ++  LSKE  +     +   +  E L
Sbjct: 357 AVGDFLAGPSHTLPTGGAGKSFPGLTVDMFQKRTSIVRLSKEACAKSEPIVRVFSEIEGL 416

Query: 417 TAHKNAVTLR 426
            AH  +V++R
Sbjct: 417 DAHGLSVSVR 426


>UniRef50_B3T638 Histidinol dehydrogenase n=1 Tax=uncultured marine crenarchaeote
           HF4000_ANIW141N1 RepID=B3T638_9ARCH
          Length = 434

 Score =  482 bits (1241), Expect = e-134,   Method: Composition-based stats.
 Identities = 157/443 (35%), Positives = 243/443 (54%), Gaps = 26/443 (5%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              I+   +  +      +       SE   +TV  IL++V+  GD A+++Y  KF+   
Sbjct: 1   MIKILQVRNVDS-----FVEYRRQKTSEKDRKTVQAILNDVRKNGDSAVKKYERKFNGRK 55

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFH----TAQK--------LPPVDVE 110
            + L+VS +EI  A E           + ++  + +       QK          P    
Sbjct: 56  TSQLRVSNKEIGEAEELPDPTDNIWTKLYLQEWDLYWNLSGRKQKLRKGGFCYEKPYFWG 115

Query: 111 TQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIA 166
             P ++ ++   P+ SVG YIPGG A   S+V+M   PA IAG K++V+ SPP     I 
Sbjct: 116 GLP-LKTEKRFVPIPSVGCYIPGGQARYPSSVVMSVLPAKIAGVKRIVIVSPPGRDGKID 174

Query: 167 DEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLD 226
              + AA +CGV +++ VGGAQAI ALA+GT+S+PKVDKI GPG  FV+ AK  VS   +
Sbjct: 175 PLTISAAAMCGVTEIYKVGGAQAIGALAYGTKSIPKVDKIVGPGGKFVSIAKAIVS---E 231

Query: 227 GAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVE 286
             +IDM AGP+E+ ++AD+ + P+ VA DL+SQAEH  D+   ++T +  +A+++ +++E
Sbjct: 232 QTSIDMIAGPTELGIMADTSSDPELVALDLISQAEHSKDTMCFVITQSKIIAKQIQKSIE 291

Query: 287 RQLAELPRAETARQAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSA 345
           + +    R+   R++L     + V K+  + +E++N+  PEHL +  +NAR L   IT A
Sbjct: 292 KLIPGTERSSIIRESLTKNGFIAVCKNENEMIELANKIAPEHLELMVKNARSLSKKITGA 351

Query: 346 GSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALAS 405
           G + +G  +P SA DY  GTNH+LPT G+  T   L + DF K  T+ E  K    AL+S
Sbjct: 352 GLLLIGKNTPSSASDYILGTNHILPTNGFGRTRGGLSVLDFLKLQTIVESKKSTLKALSS 411

Query: 406 TIETLAAAERLTAHKNAVTLRVN 428
            ++ L  AE L  H  AV  R++
Sbjct: 412 DLKALTDAEGLPNHYKAVKRRLD 434


>UniRef50_C0G418 Histidinol dehydrogenase n=2 Tax=Rhizobiales RepID=C0G418_9RHIZ
          Length = 444

 Score =  481 bits (1240), Expect = e-134,   Method: Composition-based stats.
 Identities = 155/411 (37%), Positives = 218/411 (53%), Gaps = 14/411 (3%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
             T +       EQ+    +      SE + R V +I+D V+  GD AL +YS +FD+  
Sbjct: 1   MVTTLRQTDPDFEQKFAAFLSGKREVSEDVDRAVREIVDRVRREGDSALLDYSRRFDRID 60

Query: 63  VTA--LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQV 120
           +    + V+  EI AA +       +A+ +A   IE  H  Q           GV     
Sbjct: 61  LEKTGIAVTEAEIDAAFDAAPASTVEALKLARDRIEKHHARQLPKDDRYTDALGVELGSR 120

Query: 121 TRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCG 177
              + +VGLY+PGG+A   S+VLM A PA +AG  ++V+  P P   +   +L AA+L G
Sbjct: 121 WTAIEAVGLYVPGGTASYPSSVLMNAMPAKVAGVDRIVMVVPAPDGNLNPLVLVAARLAG 180

Query: 178 VQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPS 237
           V +++ VGGAQAIAALA+GTE++  V KI GPGNA+V  AKR V   +    IDM AGPS
Sbjct: 181 VSEIYRVGGAQAIAALAYGTETIRPVAKIVGPGNAYVAAAKRIVFGTV---GIDMIAGPS 237

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAET 297
           EVL++AD    PD++A+DLL+QAEH   +Q IL+T     A  V EAVERQL  L R ET
Sbjct: 238 EVLIVADKDNNPDWIAADLLAQAEHDTAAQSILMTNDEAFAHAVEEAVERQLHTLARTET 297

Query: 298 ARQAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPE 356
           A  +  +   +I+ KD    + ++N+   EHL I   +A   V  I +AGS+F+G ++P 
Sbjct: 298 ASASWRDFGAVILVKDFEDAIPLANRIAAEHLEIAVADAEAFVPRIRNAGSIFIGGYTPG 357

Query: 357 SAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQEL-SKEGFSALAST 406
           S      G   + P     A C  L L  F  R+    L S+ G  A + T
Sbjct: 358 SDRRLCGG---LQPCAANGALCPFL-LRPFGARLYEAHLASQAGLRAASRT 404


>UniRef50_Q13I58 Histidinol dehydrogenase n=22 Tax=cellular organisms
           RepID=Q13I58_BURXL
          Length = 443

 Score =  481 bits (1239), Expect = e-134,   Method: Composition-based stats.
 Identities = 141/424 (33%), Positives = 211/424 (49%), Gaps = 10/424 (2%)

Query: 17  QRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAA 76
           +R         +   +   V  I+ +++ +GDEA+REYS KFD       ++S  EI  A
Sbjct: 10  KRGRTAAGKSDSDAKVRAIVESIIQHIEEKGDEAVREYSRKFDNWDPGDFRLSRPEIETA 69

Query: 77  SERLSDELKQAMAVAVKNIETFHTAQK--LPPVDVETQPGVRCQQVTRPVASVGLYIPGG 134
            ++LS    + +A A   +  F   Q+  +  V+ ET PGV       P+ +VG YIPGG
Sbjct: 70  RKQLSAREIEDIAFAQTQVRNFARIQRDSMRDVETETLPGVVLGHKHIPMNAVGCYIPGG 129

Query: 135 SAPLFSTVLMLATPASIAGCKKVVLCSPP---PIADEILYAAQLCGVQDVFNVGGAQAIA 191
             PL ++  M    A +AG  +VV  +PP        I+ A  + G  ++  +GG QA+ 
Sbjct: 130 KYPLLASAHMSVLTAKVAGVARVVSTAPPYQGKPHPAIVTAMDMAGADEILVLGGIQAVV 189

Query: 192 ALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDF 251
           A+A GT +V  VD + GPGN FV EAKRQ+  R+    ID+ AGP+E LVIAD     + 
Sbjct: 190 AMAVGTPTVAPVDMLVGPGNMFVAEAKRQLYGRV---GIDLFAGPTETLVIADESVDGEL 246

Query: 252 VASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVT 310
            A DLL QAEHG  S  ILLT +  +AR     +ERQL  LP A  A Q+  +   +IV 
Sbjct: 247 CAVDLLGQAEHGATSPSILLTNSEKLARDTLAEIERQLKILPTASIAAQSWADCGEVIVC 306

Query: 311 KDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLP 370
               + +++++    EH+ + T +    ++++T+ G++FLG  +  S GD   GTNH LP
Sbjct: 307 DTYEEMLQVADDIASEHVQVMTEDPDFFLNNMTNYGALFLGPRTNVSFGDKVIGTNHTLP 366

Query: 371 TYGYTATCSSLGLADFQKRMTVQEL-SKEGFSALASTIETLAAAERLTAHKNAVTLRVNA 429
           T         L +  F K  T Q + + E  + +      L   E    H     +RV  
Sbjct: 367 TNRSARYTGGLWVGKFLKTCTYQRVTTNEASAIIGEYCSRLCHMENFAGHGEQANIRVRR 426

Query: 430 LKEQ 433
              +
Sbjct: 427 YGNR 430


>UniRef50_P73058 Histidinol dehydrogenase 1 n=11 Tax=Cyanobacteria RepID=HISX1_SYNY3
          Length = 434

 Score =  479 bits (1233), Expect = e-133,   Method: Composition-based stats.
 Identities = 162/438 (36%), Positives = 249/438 (56%), Gaps = 14/438 (3%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFD--K 60
              I+  +  T +Q  QL  R   +  +++     ++++ VK  GD  +  YS +FD   
Sbjct: 1   MTRILKLSHLTPQQLNQLKRRSEQNIDQAL-AIAKEVIEQVKMEGDAGVLHYSRQFDFAG 59

Query: 61  TTVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDV-ETQPGVRCQQ 119
            T   L+VS  E A A + +  EL++A+  A +NIE  H  Q  PP+ + E +PGV   +
Sbjct: 60  ATAENLRVSEAEFAEAEKLVDPELRRAVEHAFRNIEKVHAGQMPPPMHLAEIEPGVFAGE 119

Query: 120 VTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQL 175
              P+ +VGLY+P G     S +LMLA PA +AG KK+V+C+PP     +    L  A++
Sbjct: 120 KITPLPTVGLYVPRGKGAFPSMMLMLAVPARVAGVKKIVVCTPPDKEGKVEPVSLVTARM 179

Query: 176 CGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAG 235
            GV +V+ +GG QA+AA+A+GT++V KVDK+ GP + +   AKR +S  +D   + +PAG
Sbjct: 180 AGVDEVYKLGGVQALAAIAYGTKTVSKVDKLIGPCSIYGAAAKRLLSGIVD---VGLPAG 236

Query: 236 PSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELP-- 293
           PSE +V+AD    P   A DLL +AEHG DS  +L+T +A +A +    +   L +LP  
Sbjct: 237 PSESIVLADETTDPKLAALDLLIEAEHGSDSAALLVTHSASLAEKALGYLGEYLEKLPPW 296

Query: 294 RAETARQAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGD 352
           R +     L +   +++T  L   ++  N Y PEHL + T +  +LV  I +AG + LG+
Sbjct: 297 RKKFCEDGLGSYGGILLTDSLQASLDFINDYAPEHLQVLTADPLKLVGKIDNAGEILLGN 356

Query: 353 WSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAA 412
           ++P SA  YA G N VLPT G+  + S++ + DF KR T+  L++EGF+ +  T+ TLA 
Sbjct: 357 YTPSSAATYAIGVNAVLPTGGFARSYSAVSVFDFLKRSTLAYLTEEGFAGVKETVTTLAD 416

Query: 413 AERLTAHKNAVTLRVNAL 430
            E   AH  A+  R N L
Sbjct: 417 YEDFPAHALAIRERENLL 434


>UniRef50_D0XPF3 Histidinol dehydrogenase n=1 Tax=Brevundimonas subvibrioides ATCC
           15264 RepID=D0XPF3_9CAUL
          Length = 440

 Score =  476 bits (1225), Expect = e-132,   Method: Composition-based stats.
 Identities = 176/432 (40%), Positives = 251/432 (58%), Gaps = 9/432 (2%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
              IDW S   + +   L RP+  +   +   V+ I + V   G  A+ +++ + D    
Sbjct: 6   IKRIDWASLDGQGRFDALARPSRRSERDVQDVVSGIFEQVALSGGLAVTQFAERIDGFKP 65

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPV-DVETQPGVRCQQVTR 122
             + ++ E +AAA + L     +A+ VA +N+  FH A K      VET PGV+ + V R
Sbjct: 66  RRIAITPEAVAAARDALPPADTRALRVAAENVRVFHQATKPEDTAFVETTPGVKSKLVWR 125

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGV 178
           P+ + G+Y+PGG+APLFS++LM A PA +AG    V+ +PP     +   ++ AA    +
Sbjct: 126 PIGAAGIYVPGGTAPLFSSLLMQAIPAEVAGVTTRVVVTPPAKDGSVHPAMILAAAEANL 185

Query: 179 QDVFNVGGAQAIAALAFGT----ESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPA 234
             ++ +GGAQAIAAL +G       +P  DK+FGPGNA+V EAKR  +   +G ++DMPA
Sbjct: 186 DAIWLIGGAQAIAALTYGAVLDDGEIPACDKLFGPGNAYVAEAKRYAAALPNGPSVDMPA 245

Query: 235 GPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPR 294
           GPSE+LVIAD    P+  A+DLLSQAEH  D+QVIL+   A     +   VE QL  LPR
Sbjct: 246 GPSELLVIADRFCDPEIAAADLLSQAEHDADAQVILVCERAATIDAILAEVEEQLTTLPR 305

Query: 295 AETARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWS 354
           A+ AR +L+ +R I+  D+A+   +SN YGPEHL IQ  +A  LV SI +AG+VF+G W+
Sbjct: 306 ADIARASLSEARAILVSDMAEACAVSNLYGPEHLAIQAEDAEALVASIRAAGAVFVGRWA 365

Query: 355 PESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAE 414
            E+ GDYA+G +HVLPT G   T   +  A F   M+VQ +++ G   L      LA  E
Sbjct: 366 AETLGDYAAGPSHVLPTDGGARTLGGITTASFMTSMSVQTVTEAGAERLGPIAARLARLE 425

Query: 415 RLTAHKNAVTLR 426
            L AH  A  LR
Sbjct: 426 GLEAHARAADLR 437


>UniRef50_Q4JW59 Histidinol dehydrogenase n=104 Tax=Actinobacteria (class)
           RepID=HISX_CORJK
          Length = 450

 Score =  474 bits (1222), Expect = e-132,   Method: Composition-based stats.
 Identities = 158/439 (35%), Positives = 233/439 (53%), Gaps = 15/439 (3%)

Query: 7   IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTAL 66
           +   + T  + R  L R       S+  TV  I+D V+  G  A  E   +FD  T  ++
Sbjct: 13  LRGQAPTTAELRHRLPRGGTDVD-SVIPTVAPIVDQVREGGARAALEIGQRFDGVTPDSV 71

Query: 67  KVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVAS 126
           +V AE I AA   L+D++  A+  A+K +  FH+A +     VE  PG    +   PV  
Sbjct: 72  RVPAEVIDAAVGTLADDVIAALEEAIKRVRAFHSAIRPEDKQVEVAPGGIVTERFIPVQR 131

Query: 127 VGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQDVF 182
           VGLY PGG+A   S+V+M   PA  AG + +V+ SPP         +L A +L GV +V+
Sbjct: 132 VGLYAPGGNAVYPSSVIMNVVPAQEAGVESLVVASPPQEGGWPHPTVLAACKLLGVDEVW 191

Query: 183 NVGGAQAIAALAFGT-----ESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPS 237
            VGGAQA+A LA G+     E +  VD + GPGN FVT AKR     +    ID  AGP+
Sbjct: 192 AVGGAQAVALLAHGSTAEGGEELEPVDMVTGPGNIFVTAAKRLCRSVV---GIDSEAGPT 248

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAET 297
           E+ V+AD  A    +A DL+SQAEH   +  +L+T +  +A  V   +  +      +E 
Sbjct: 249 EIAVLADESANAVEIAYDLISQAEHDTMAASVLITDSEKLADEVVAEMNERYHITENSER 308

Query: 298 ARQALN--ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSP 355
             +AL+   S +++  D+A  +  +N YG EHL I T +A  +   IT+AG++F+G +SP
Sbjct: 309 VAEALSGQQSGVVLVDDIAAGIRAANAYGAEHLEIHTEDAHGVAAQITNAGAIFIGRFSP 368

Query: 356 ESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAER 415
              GDYA+G+NHVLPT G     S L    F K + V + ++EG   +A T+ TL+ +E 
Sbjct: 369 VPLGDYAAGSNHVLPTSGTARHSSGLSTLTFLKSVHVIDYNEEGLRGVADTVITLSKSEG 428

Query: 416 LTAHKNAVTLRVNALKEQA 434
           L AH  A++ R +      
Sbjct: 429 LPAHGEAISARTSTANTNG 447


>UniRef50_B4W8G9 Histidinol dehydrogenase n=2 Tax=Caulobacteraceae
           RepID=B4W8G9_9CAUL
          Length = 435

 Score =  472 bits (1216), Expect = e-131,   Method: Composition-based stats.
 Identities = 193/434 (44%), Positives = 261/434 (60%), Gaps = 9/434 (2%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
             +IDW+S  A  +R  L RPA   +  +T  V  ILD+V+ARG  A+ ++  K DK   
Sbjct: 1   MKLIDWSSLDAAGKRAALARPAQRTAGDVTDVVRTILDDVRARGGAAVTDWCLKLDKAPP 60

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPV-DVETQPGVRCQQVTR 122
             + ++ E +A A   L     +A+ +A +N+  FH A K      +ET PGVR +   R
Sbjct: 61  RRIAITPEAVAEARNALPPGDVRALRMAAENVRVFHQATKPEDTPFIETTPGVRSKLAWR 120

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGV 178
           P+AS GLYIPGG+APLFS++LMLA PA +AG  + V  +PP     I   ++ AA    +
Sbjct: 121 PIASAGLYIPGGTAPLFSSLLMLAIPAGVAGVGERVAVTPPDKNGGIHPAMILAAAEAEL 180

Query: 179 QDVFNVGGAQAIAALAFGTE----SVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPA 234
             ++ +GGAQAIAAL FG E     +P  DK+FGPGNA+V EAK+Q S    G A+DMPA
Sbjct: 181 DAIWLMGGAQAIAALTFGVELEDGIIPACDKLFGPGNAYVAEAKKQASALPGGPAVDMPA 240

Query: 235 GPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPR 294
           GPSE++VI D  A P+  A+DLLSQAEH  D+QVIL++ +      +   VE Q+A LPR
Sbjct: 241 GPSELMVIVDRDAAPEIAAADLLSQAEHDADAQVILVSTSRATIDYILSEVEVQVAALPR 300

Query: 295 AETARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWS 354
              AR +LN +R I+ +DL    E++N YGPEHL IQ  +   LVDSI +AG+VF+G ++
Sbjct: 301 EAIARASLNEARAILVRDLDAAAEVANLYGPEHLAIQIDDPEPLVDSIKAAGAVFVGRFA 360

Query: 355 PESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAE 414
            E+ GDYA+G +HVLPT G   T   +  A F   M+VQ +S+ G  ALA     LA  E
Sbjct: 361 AETLGDYAAGPSHVLPTDGGARTLGGVTTASFMTTMSVQLVSEAGARALAPIAARLARME 420

Query: 415 RLTAHKNAVTLRVN 428
            L AH  A  LR  
Sbjct: 421 GLEAHARAADLRAE 434


>UniRef50_A4QA32 Histidinol dehydrogenase n=16 Tax=cellular organisms
           RepID=A4QA32_CORGB
          Length = 408

 Score =  471 bits (1214), Expect = e-131,   Method: Composition-based stats.
 Identities = 138/403 (34%), Positives = 213/403 (52%), Gaps = 10/403 (2%)

Query: 39  ILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETF 98
           ++ +++ARGDEA+REYS KFD     +  V  E++    +R+ +++ + +      +   
Sbjct: 1   MIADIRARGDEAVREYSLKFDNYGPDSFLVQGEQLQEILDRVPEQVIEDIKFVQDQVRKV 60

Query: 99  HTAQKLP--PVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKK 156
             AQ       ++ET PGV   Q   P+ S G Y+PGG  PL ++  M    A +AG K+
Sbjct: 61  AQAQLQSMGEFEIETLPGVHIGQKNVPIDSAGAYVPGGKYPLLASAHMTILTAKVAGVKR 120

Query: 157 VVLCSP---PPIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAF 213
           VV C+P     + D  + A  L G  +++ +GG QAIAA+A GTE++  V  I GPGNAF
Sbjct: 121 VVACTPLIQGEVPDATVAAMHLAGADEIYLLGGIQAIAAMAIGTETIKPVSIIAGPGNAF 180

Query: 214 VTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTP 273
           V EAKRQ+   +    ID+ AGP+E L++AD    P   A DLLSQAEHGPDS  +L++ 
Sbjct: 181 VAEAKRQLFGEV---GIDLLAGPTETLIVADETTDPFIAAVDLLSQAEHGPDSPAVLIST 237

Query: 274 AADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQT 332
              +A +V + +   L E+P  + A  A  +   + V + +     +++++  EH+ I T
Sbjct: 238 DRAVAEQVIDHINELLPEMPTKDYAEVAWRDWGEVHVVESIEDAFSLADKFASEHVQILT 297

Query: 333 RNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTV 392
            + R  +D +   G++FLG+ +  S GD   GTNHVLPT G       L +  + + +T 
Sbjct: 298 ASPRRALDEMKHYGALFLGEGTCVSYGDKVIGTNHVLPTRGAARYTGGLWVGKYVRTITY 357

Query: 393 QELSKEGFSA-LASTIETLAAAERLTAHKNAVTLRVNALKEQA 434
           QE++ E  SA         A  ER   H  +  +R       A
Sbjct: 358 QEVTNEDSSAFFGELCGRAARVERFEGHARSGDVRAAKYAGAA 400


>UniRef50_Q64EP7 Histidinol dehydrogenase n=2 Tax=environmental samples
           RepID=Q64EP7_9ARCH
          Length = 419

 Score =  471 bits (1214), Expect = e-131,   Method: Composition-based stats.
 Identities = 172/425 (40%), Positives = 245/425 (57%), Gaps = 28/425 (6%)

Query: 16  QQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV---TALKVSAEE 72
           + +    R       ++   VN+I+  VK+RGD AL +Y+ KFD         L+V   E
Sbjct: 10  ETKDFFDRGL--DLTAVMPLVNEIIAEVKSRGDRALLDYTEKFDGVKFLRQKDLEVRRSE 67

Query: 73  IAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQP-----GVRCQQVTRPVASV 127
           I  A   + D L +++  A + I+ FH  QK      + +      G+       P+  V
Sbjct: 68  IEDAKRNVDDHLLRSIEKASEAIKKFHYRQKRRVEVEKGEDKGGTEGMFIDNTYVPLDVV 127

Query: 128 GLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEI-----LYAAQLCGVQDVF 182
           G Y+P   A  FST LM   PA IAG + +++C+PP     +     L AA+L G   +F
Sbjct: 128 GAYVP---ASYFSTALMCVIPAKIAGVRNILVCTPPGKDGAVDSLTLLAAAELAGATRIF 184

Query: 183 NVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVI 242
            VGGAQAIAALAFGTE++PKV KI GPGN +VT AK   + R  G  ID PAGPSE+++I
Sbjct: 185 KVGGAQAIAALAFGTETIPKVQKIVGPGNVYVTAAKM--AARAQGVEIDFPAGPSEIIII 242

Query: 243 ADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL 302
           AD  A P F+ +D+L+QAEHG  S+ +LLT +A    R+A  VERQ+    R E   +  
Sbjct: 243 ADETANPLFIVADMLAQAEHGAKSKAVLLTDSA----RIAAEVERQI----RTEAGDEEG 294

Query: 303 NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYA 362
             + +I+  D+ +C+E++N+Y PEHL I  R  +E++  I +AGSVF+GD+SP +AGDYA
Sbjct: 295 EQNGIILGDDIGECIELANEYAPEHLEIMVREPKEVLKRIKNAGSVFVGDYSPVAAGDYA 354

Query: 363 SGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNA 422
           +G NHVLPT GY  + S L +  F +RMTVQ L KEG + +   +  ++ AE +  H  +
Sbjct: 355 TGANHVLPTAGYAKSFSGLDVHHFMRRMTVQWLDKEGLAKIKDVVVKMSRAEGMEKHAQS 414

Query: 423 VTLRV 427
           V  R 
Sbjct: 415 VEARF 419


>UniRef50_D2RSH8 Histidinol dehydrogenase n=1 Tax=Haloterrigena turkmenica DSM 5511
           RepID=D2RSH8_9EURY
          Length = 432

 Score =  470 bits (1210), Expect = e-131,   Method: Composition-based stats.
 Identities = 161/430 (37%), Positives = 240/430 (55%), Gaps = 10/430 (2%)

Query: 9   WNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKV 68
                   +     R   +  ++I+  V +I+D V   GD A+RE++++FD   +  + +
Sbjct: 8   LADLGPADRTAFFDR--DAGIDAISDDVREIVDRVHEEGDVAVREFTSEFDDVELGNIDI 65

Query: 69  SAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVG 128
           + +    A E L  ++++A+  A  N+  FH AQ       E  PG    +  RP+  VG
Sbjct: 66  T-DACERAYEDLEGDVREAIETAADNVREFHEAQLPEDWRREFGPGRELGRRFRPIERVG 124

Query: 129 LYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP--PIADEILYAAQLCGVQDVFNVGG 186
           +Y+PGGSA   S+ +M   PA +AG   V + +PP   +    L A  + G   V++VGG
Sbjct: 125 VYVPGGSAAYPSSAIMGVVPAVVAGVDHVAVVTPPADELNPVTLAAIHVAGADAVYSVGG 184

Query: 187 AQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSG 246
           AQAIA LA+GTE++ +V KI GPGN +VT AK  V   ++   ID  AGPSEV+V+AD  
Sbjct: 185 AQAIAGLAYGTETITRVQKIVGPGNKWVTAAKAAVRGDVE---IDFLAGPSEVVVVADET 241

Query: 247 ATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNA-- 304
           A PD VA++L++QAEH P++ V+ +T  A+ A  VA AV+ Q     R +  R A     
Sbjct: 242 ADPDLVAAELVAQAEHDPNASVVAVTDDAETADAVAAAVDGQTEARKREDVIRGAFENDA 301

Query: 305 SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASG 364
           S +++ + +++ +  + +Y PEHL I   +   +++ I SAGSVFLG  +P +AGDYASG
Sbjct: 302 SGVLLARSMSEAILFTEEYAPEHLSIIADDEESILERIDSAGSVFLGPNTPVAAGDYASG 361

Query: 365 TNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVT 424
           TNHVLPT G       L +  F +  TVQ LS EG + +  TI TLA AE L AH  +V 
Sbjct: 362 TNHVLPTNGGARVTGGLSIETFLRSTTVQRLSAEGLADIGDTITTLADAEGLEAHAESVR 421

Query: 425 LRVNALKEQA 434
            R+   +   
Sbjct: 422 QRLEDREGDG 431


>UniRef50_Q1AX10 Histidinol dehydrogenase n=1 Tax=Rubrobacter xylanophilus DSM 9941
           RepID=Q1AX10_RUBXD
          Length = 418

 Score =  469 bits (1209), Expect = e-131,   Method: Composition-based stats.
 Identities = 160/429 (37%), Positives = 231/429 (53%), Gaps = 20/429 (4%)

Query: 7   IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTAL 66
           +D     A +  + L RP    S  +   V  +++ V+ RGDEAL EY  +FD      L
Sbjct: 5   LDARGLDAREVVRRLRRPRGFLSREVRAAVRQVVEEVRERGDEALLEYGERFDGVRPDPL 64

Query: 67  KVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVAS 126
           +V  EEI  A   L  EL +A   A++N+  FH  +     ++E + G R  Q  RP+  
Sbjct: 65  RVPREEIERARAALPGELAEAFRTAIENVRRFHERELDRSWELE-RGGARLGQRVRPLRR 123

Query: 127 VGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQDVF 182
            G+Y+PGG     ST++M A PA +AG +++ +C+PP         +L  A L G+ +V+
Sbjct: 124 AGIYVPGGHGAYPSTLVMTAVPAQVAGVEELCVCTPPGPDGRANPRLLAVAGLLGIGEVY 183

Query: 183 NVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVI 242
             GGAQA+AA+AFGTESVP+VDKI GPGN +VT AK +V   +    +D P GPSE++V+
Sbjct: 184 AAGGAQAVAAMAFGTESVPRVDKIVGPGNDYVTAAKLEVFGEV---GVDAPQGPSELVVV 240

Query: 243 ADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL 302
           AD  A P+ VA DL++QAEH   +  +LLTP+  +A  V    E  L+  P         
Sbjct: 241 ADGSARPERVALDLMAQAEHLSGATSVLLTPSGALASGV----EPLLSGRPSEHIT---- 292

Query: 303 NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYA 362
               L++ +DL Q +EISN Y PEH+ +    A   ++ + +AG V +GD SP +  DYA
Sbjct: 293 ----LVLVRDLEQALEISNLYAPEHVHLNCEGAGAALERVEAAGLVAVGDLSPVALSDYA 348

Query: 363 SGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNA 422
           +G +H LPT G     S+LG  DF  R+     S+E    L   +E LA  E    H  +
Sbjct: 349 AGPSHALPTGGTARWASALGTHDFLTRINHMRFSREALRELGPHVERLARMEGFENHAAS 408

Query: 423 VTLRVNALK 431
           V  R    +
Sbjct: 409 VAARREKEE 417


>UniRef50_A3Q131 Histidinol dehydrogenase n=6 Tax=Mycobacterium RepID=A3Q131_MYCSJ
          Length = 474

 Score =  469 bits (1208), Expect = e-131,   Method: Composition-based stats.
 Identities = 157/473 (33%), Positives = 228/473 (48%), Gaps = 48/473 (10%)

Query: 1   MSFNTI-IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFD 59
           ++   I +   + +  Q R  L R  +     +   V  I++ V  RG EA  EY   FD
Sbjct: 6   VTMARIDLRGRTLSTAQLRSALPRGGVDVDAVV-PKVRPIVEAVAERGAEAALEYGEAFD 64

Query: 60  KTTVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQ 119
                +++V AE +A+A   L  +++ A+ VA+      H  Q+         PG    +
Sbjct: 65  GVRPASVRVPAERLASALAELDPDVRAALQVAIDRARAVHADQRRTDTTTTLAPGATVTE 124

Query: 120 VTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPI------ADEILYAA 173
              P+  VGLY+PGG+A   S+V+M   PA  AG   +V+ SPP           IL AA
Sbjct: 125 RWVPLERVGLYVPGGNAVYPSSVVMNVVPAQTAGVDSLVIASPPQADHGGLPHPTILAAA 184

Query: 174 QLCGVQDVFNVGGAQAIAALAFGTESV--------------------------------- 200
            L GV +V+ VGGAQA+A LA+G   +                                 
Sbjct: 185 ALLGVDEVWAVGGAQAVALLAYGGTDIDGTGASGAPGDGTGASGAPGDGTGASGAPGDVT 244

Query: 201 --PKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLS 258
               VD I GPGN +VT AKR    ++    ID  AGP+E+ V+AD  A P  VA+DL+S
Sbjct: 245 ELAPVDMITGPGNIYVTAAKRICRSQV---GIDAEAGPTEIAVLADHTADPVHVAADLIS 301

Query: 259 QAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL--NASRLIVTKDLAQC 316
           QAEH   +  +L+T + D+A  +   + RQL      E    AL    S +++  DL   
Sbjct: 302 QAEHDEMAASVLVTTSPDLADAIDRELRRQLETTVHRERVSTALTGEQSAIVLVDDLDAG 361

Query: 317 VEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTA 376
           V + N Y  EHL IQT +A E+   I SAG++F+G ++P S GDY +G+NHVLPT G   
Sbjct: 362 VRVVNAYAAEHLEIQTVDAAEVAGRIRSAGAIFVGPYAPVSLGDYCAGSNHVLPTAGCAR 421

Query: 377 TCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNA 429
             S L +  F + + V + ++     ++  + TLA AE L AH  AV  R  +
Sbjct: 422 HSSGLSVQTFLRGIHVVDYTEAALKDVSGYVITLAQAENLPAHGEAVRRRFES 474


>UniRef50_A9A5X6 Histidinol dehydrogenase n=2 Tax=Thaumarchaeota RepID=A9A5X6_NITMS
          Length = 420

 Score =  468 bits (1206), Expect = e-130,   Method: Composition-based stats.
 Identities = 152/430 (35%), Positives = 237/430 (55%), Gaps = 15/430 (3%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
             II  N+       Q L +     S    + V  IL +VK  GD A+++Y  KF    V
Sbjct: 1   MKIISINNTE-----QFLKKIGTKDSSKNQKIVKSILKDVKKNGDVAVKKYEKKFS-AKV 54

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQ-PGVRCQQVTR 122
           ++L+VS  +IA+A  ++S E   A+ +A   +    +A +    D+  +  G +  +   
Sbjct: 55  SSLRVSQRDIASAYFKVSKEDISAIKLAKSRLSKAESAVRRQFKDITIKSNGTKLSKSFV 114

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGV 178
           P+ SVG Y+PGG+A   S+ +M   PA IAG K++V+ SPP     I    + AA LCG 
Sbjct: 115 PIDSVGCYVPGGAARYPSSAIMSVVPAKIAGVKRIVVVSPPNSSGNIDPLTIVAADLCGA 174

Query: 179 QDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSE 238
            +++  GG Q+IAAL +GT S+ KV+KI GPG AFVT AK  VS  +   +IDM AGP+E
Sbjct: 175 TEIYKTGGVQSIAALTYGTRSIKKVNKIVGPGGAFVTLAKYLVSNIV---SIDMMAGPTE 231

Query: 239 VLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETA 298
           + ++ DS A  D  A DL+SQAEH  D+    LT +  +A+++  +V  +L ++ R +  
Sbjct: 232 LGIVIDSAADVDVAALDLISQAEHSSDTFCYALTTSNSIAKKIQSSVNSKLKDIQRVKIV 291

Query: 299 RQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESA 358
           + +L ++  I     +  ++I+N   PEHL I ++N ++  + I + G +  G  SP SA
Sbjct: 292 KSSLESNGFIGVCKPSDIIDIANDLAPEHLEIISKNPKKW-NKIKNPGLILYGKNSPSSA 350

Query: 359 GDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTA 418
            DY  G+NH+LPT G+  T  SL + DF K +T  E +K+    ++ +++ L  AE L  
Sbjct: 351 SDYLLGSNHILPTNGFGKTRGSLSVLDFVKLLTKIETTKKDLQKISKSMKNLTLAEGLPN 410

Query: 419 HKNAVTLRVN 428
           H  AV  R+ 
Sbjct: 411 HYEAVRGRLK 420


>UniRef50_D1B7M0 Histidinol dehydrogenase n=2 Tax=Bacteria RepID=D1B7M0_THEAS
          Length = 424

 Score =  468 bits (1205), Expect = e-130,   Method: Composition-based stats.
 Identities = 162/420 (38%), Positives = 236/420 (56%), Gaps = 13/420 (3%)

Query: 19  QLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASE 78
           ++  R + S    ++  V  I+D V   GD A+ E S   D+++  ++ V  EE+  A  
Sbjct: 8   RVKDRASSSDLYGVSHEVRRIIDWVVLHGDRAVLEGSRLHDRSSRDSILVPVEELQRAHR 67

Query: 79  RLSDELKQAMAVAVKNIETFHTAQK---LPPVDVETQPGVRCQQVTRPVASVGLYIPGGS 135
            +  EL +A+  A  N+ETF   QK   +P  + E + GV       PV S G+YIPGGS
Sbjct: 68  SMDPELLEAVRYAASNVETFAQRQKGALMPLEESEVRDGVYLGHRVVPVDSCGIYIPGGS 127

Query: 136 APLFSTVLMLATPASIAGCKKVVLCSP-----PPIADEILYAAQLCGVQDVFNVGGAQAI 190
            PL ST +MLA PA +AG  ++  C+P           +L      GV +V+  GGA A+
Sbjct: 128 YPLISTAVMLAVPARVAGVGRICACTPVRRGTNSPDPSVLGTLYELGVTEVYAAGGAYAV 187

Query: 191 AALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPD 250
           AA+A GTES+P VD I GPGN +VTEAKRQ   ++    ID  AGPSEVL+IA  G  PD
Sbjct: 188 AAMAHGTESIPPVDVIVGPGNKYVTEAKRQCFGKV---GIDFVAGPSEVLIIAQEG-DPD 243

Query: 251 FVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIV 309
           F+A DLL+QAEH PD++ +L+T +  +AR+V + VE  L E+  +  AR +  +   ++ 
Sbjct: 244 FIAWDLLAQAEHDPDAKGVLVTTSPALARQVMDRVETILGEIVTSPVARSSWEDHGEVLA 303

Query: 310 TKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVL 369
            + + + VE SN+  PEHL +  ++    +  + + G++F+G+ S E  GDYASG+NH L
Sbjct: 304 AEGMDEAVEFSNRMAPEHLELMVQDPDRWIPRLRNYGALFIGEHSAEVFGDYASGSNHTL 363

Query: 370 PTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNA 429
           PT G +     L +  F K +T Q +++EG   LA     LA AE L AH+ A   R   
Sbjct: 364 PTAGASRYTGGLWVGTFLKVLTSQRVTREGARELARVSALLAQAEGLMAHRGAALARSRK 423


>UniRef50_B2UMH6 Histidinol dehydrogenase n=3 Tax=Verrucomicrobia RepID=B2UMH6_AKKM8
          Length = 432

 Score =  466 bits (1200), Expect = e-130,   Method: Composition-based stats.
 Identities = 158/436 (36%), Positives = 246/436 (56%), Gaps = 11/436 (2%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
             I   +    ++ ++ + R A+   +S+  TVN I+ +V  RGDEAL +Y+A+FDK  +
Sbjct: 1   MKIYRPSDTCFDEMKRRMNRRAL-PEDSVRDTVNAIIRDVSVRGDEALFDYAARFDKAHL 59

Query: 64  --TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVT 121
             ++L V+  E+A A   + + +K+A+AV++ NI  F    +          GV   +  
Sbjct: 60  DSSSLFVTEAELAEAEAMVEESVKEAIAVSLANIHYFSDRSRRRDWSGVNAQGVEVAERF 119

Query: 122 RPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSP----PPIADEILYAAQLCG 177
            P   VG+YIPGG APL ST +M    A  AG +++V  +P      +   +LYA +  G
Sbjct: 120 LPYDRVGIYIPGGKAPLVSTSIMTGGFAQAAGVREIVAATPCGPDGRVNPALLYALKASG 179

Query: 178 VQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPS 237
             ++  +GGAQAIAALA GTESV  V+KIFGPGN FV EAKRQ+   +   AID+  GPS
Sbjct: 180 ATEIVKIGGAQAIAALALGTESVRPVEKIFGPGNRFVVEAKRQL---VGAVAIDLLPGPS 236

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAET 297
           EV+V+AD  A  +F+A+DLL+Q EHGPDS V+ +T +  +  +V   VERQ A L R   
Sbjct: 237 EVMVLADDTADAEFLAADLLAQGEHGPDSVVVFVTTSKALLEQVEAEVERQAALLSRGSI 296

Query: 298 ARQALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPE 356
            R+ L+  +   +   + + VE+ N + PEHL++ TR+   +++ I +AG+++ G  S  
Sbjct: 297 IREVLDKHAYGFLVSSIQEGVELVNAFAPEHLVLVTRDEEAVLNGIRTAGAIYAGSLSTV 356

Query: 357 SAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERL 416
           + GD+ +G +H LPT G   + S L    FQ+R +V  + +      A  +   A  E L
Sbjct: 357 ACGDFLAGPSHTLPTGGAGKSFSGLRADQFQRRTSVVRMDRNAVLNSAPYVAEFARVEGL 416

Query: 417 TAHKNAVTLRVNALKE 432
            AH +++ +R   +  
Sbjct: 417 DAHNHSIQVRAARVDR 432


>UniRef50_B6A0U7 Histidinol dehydrogenase n=1 Tax=Rhizobium leguminosarum bv.
           trifolii WSM2304 RepID=B6A0U7_RHILW
          Length = 448

 Score =  464 bits (1196), Expect = e-129,   Method: Composition-based stats.
 Identities = 164/443 (37%), Positives = 236/443 (53%), Gaps = 16/443 (3%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
            +I   ++    Q++ LL R     S  I   VN I++ V+  GD AL +++ +FDK  V
Sbjct: 6   VSIHTLSALDDAQRKALLQRTESDLSAFI-DKVNPIIEAVRIDGDAALADFARQFDKAQV 64

Query: 64  --TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDV-ETQPGVRCQQV 120
               L+ + EE +AA   +  EL   +  A  NI  FH  Q    + + ET  GV     
Sbjct: 65  AADQLRATTEEFSAARASIDPELITTLEFAAGNIRHFHEKQMPETLVLHETHRGVLVGDR 124

Query: 121 TRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLC 176
              + SV  Y+P G     S+VLM A PA +AG +KVV+ +PP     +    L AA++ 
Sbjct: 125 WNAIDSVACYVPRGKGSFPSSVLMTAIPAKVAGVRKVVIITPPGPDGTVDPATLVAAEIA 184

Query: 177 GVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGP 236
           GV DVF  GGAQAIAA+AFGT++VPK DK+ GPG+ +V  AK+Q+S  +D  +   PAGP
Sbjct: 185 GVSDVFKCGGAQAIAAVAFGTQTVPKCDKVVGPGSPWVVAAKKQLSSLIDPGS---PAGP 241

Query: 237 SEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELP--R 294
           SE+++ +D     + VA DL  ++EHGPDS V  +T  AD A  VA  V    + +   R
Sbjct: 242 SELIIFSDGSVPAELVALDLCVESEHGPDSSVFFVTDNADFANAVASCVPALWSRMGNIR 301

Query: 295 AETARQALN--ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGD 352
           A+ ++  L+     +++ +  A  +   N Y PEHL +   NA + +     AG + LG 
Sbjct: 302 AQYSKTVLSGPRGGIVIARTRADALAFVNDYAPEHLAVLADNAWQYLACFEHAGEILLGP 361

Query: 353 WSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAA 412
            S  S  ++  G +HVLPT G   T S L + DF KR ++  LSKE +   A+  E LA 
Sbjct: 362 HSAISVANFVLGPSHVLPTGGAAKTTSPLSVFDFLKRTSIASLSKEAYGGFAAHAERLAR 421

Query: 413 AERLTAHKNAV-TLRVNALKEQA 434
            E    H NAV T+R  AL+  A
Sbjct: 422 YEGFDGHANAVSTIRDEALRSAA 444


>UniRef50_B0S9F2 Histidinol dehydrogenase n=6 Tax=Leptospira RepID=HISX_LEPBA
          Length = 430

 Score =  464 bits (1195), Expect = e-129,   Method: Composition-based stats.
 Identities = 164/427 (38%), Positives = 235/427 (55%), Gaps = 11/427 (2%)

Query: 11  SCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSA 70
              +++     ++ A     + T  +  IL++V+ +GD+AL  Y+  FD   ++ L +  
Sbjct: 9   DRNSKELYSRFLQGAREDLTTATDRILPILESVRTQGDQALFSYTEMFDGIKLSQLTIDP 68

Query: 71  EEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLY 130
           ++I      + ++ K+A   A  NIE FH  QK      +   G R      P+ S+ +Y
Sbjct: 69  KKIKT---NVDEKTKEAFLRAKSNIEAFHMEQKRESWS-KVIDGNRLGVKYTPIPSLAVY 124

Query: 131 IPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIA--DEILY-AAQLCGVQDVFNVGGA 187
            PGG A   S+VLM   PA IAG   + L +PP      EIL   AQ+  +  +  VGGA
Sbjct: 125 APGGKALYPSSVLMGIIPAKIAGVPSIQLITPPQKDGIPEILVWLAQIMDIDRIVTVGGA 184

Query: 188 QAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGA 247
           Q IAA A+GTESVPK + I GPGNA+V  AK  +S +     I+ PAGPSEV +IAD  A
Sbjct: 185 QGIAAAAYGTESVPKSEFIVGPGNAYVAAAKSYLSGQ-GLIGIESPAGPSEVCIIADENA 243

Query: 248 TPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQA--LNAS 305
            P ++A D+LSQAEHG DS  ILLT    +A+RV+E +E   +E P+    +Q      S
Sbjct: 244 NPKWIACDMLSQAEHGEDSSAILLTTDLTLAKRVSEELEIAFSERPKRLQMKQTAIYENS 303

Query: 306 RLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGT 365
            ++V   L  C+  SN+  PEHL IQT++   +   I  AGSVFLG +SP + GDY SGT
Sbjct: 304 SILVFPTLDDCIWFSNELAPEHLEIQTKDYESVFAKIEHAGSVFLGPYSPVAMGDYISGT 363

Query: 366 NHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERL-TAHKNAVT 424
           NH+LPT   +   SSLG+  F KR+T QE++KE    L   ++ ++  E L   H  +V 
Sbjct: 364 NHILPTARGSRIYSSLGVDTFLKRVTFQEVTKESLENLYPFVKLMSELEGLDEEHGTSVK 423

Query: 425 LRVNALK 431
           +R    +
Sbjct: 424 VRTRQFQ 430


>UniRef50_D2R570 Histidinol dehydrogenase n=1 Tax=Pirellula staleyi DSM 6068
           RepID=D2R570_9PLAN
          Length = 454

 Score =  463 bits (1193), Expect = e-129,   Method: Composition-based stats.
 Identities = 159/403 (39%), Positives = 227/403 (56%), Gaps = 12/403 (2%)

Query: 33  TRTVNDILDNVKARGDEALREYSAKFDKTTVTA--LKVSAEEIAAASERLSDELKQAMAV 90
           T  V  I  +V+ RG  A+ +YS K D+  +T   ++VS  E+ AA          A+A 
Sbjct: 57  TEVVETICRDVRERGIAAVLDYSKKLDRADLTPETIRVSQAELDAAHAAADPAFLAAIAR 116

Query: 91  AVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPAS 150
             +NI  F TA     V+V  + GV  +Q  +P+  +G+ +PGG+A   STVLM A PA 
Sbjct: 117 IQQNILEFQTAILHKEVEVR-RNGVVLRQRYQPLERIGICVPGGAAAYPSTVLMTAVPAQ 175

Query: 151 IAGCKKVVLCSPPPI----ADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKI 206
            AG  ++V+ +PP        ++L   +  GV +V+ +GGAQ +AALA+G E +PKVDKI
Sbjct: 176 AAGVSQIVVIAPPTDFGANNRDVLATCKAIGVTEVYRMGGAQGVAALAYGVEGIPKVDKI 235

Query: 207 FGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDS 266
            GPGN FV  AKR V   +D   ID  AGPSEV+VI+D     DF A+DLL+QAEH P +
Sbjct: 236 VGPGNLFVALAKRHVYGEVD---IDSIAGPSEVVVISDETTRADFTAADLLAQAEHAPGA 292

Query: 267 QVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVEISNQYGP 325
             IL+T +          +ER +  + R+E   Q+L +   LI+     +   ++++  P
Sbjct: 293 -SILITWSRTALEATKRELERLVQTISRSELTLQSLRDFGCLILVDSPEEACRVTSEIAP 351

Query: 326 EHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLAD 385
           EHL I T NA  L+  I +AG+ FLG++SP + GDYA+G +HVLPT G     S L    
Sbjct: 352 EHLHIATENAGALLAKIRNAGATFLGNYSPVALGDYAAGPSHVLPTGGTARWASGLSANH 411

Query: 386 FQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVN 428
           F +  +V + S E    +A  I+ LA  E LTAH+ +V LRV 
Sbjct: 412 FLRSSSVIDYSAEALRDIAPAIQMLADKEGLTAHRLSVDLRVE 454


>UniRef50_Q2HFX2 Putative uncharacterized protein n=1 Tax=Chaetomium globosum
           RepID=Q2HFX2_CHAGB
          Length = 817

 Score =  463 bits (1193), Expect = e-129,   Method: Composition-based stats.
 Identities = 188/421 (44%), Positives = 245/421 (58%), Gaps = 34/421 (8%)

Query: 24  PAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALK--------VSAEEIAA 75
           P  +A E IT  V D+    +   DEALR  S K   T +  +         V       
Sbjct: 419 PKEAAPERITMKVFDMATASRKELDEALRRPSQKSSDTIMKIITPIIDDTSPVLKAPFPE 478

Query: 76  ASERLSDELKQAMAVAVKNIETFHTAQKL-PPVDVETQPGVRCQQVTRPVASVGLYIPGG 134
           +  +L  E  +AM V+ +NI  FH AQK   P+ VET PGV C + +RP  +VGLY+PGG
Sbjct: 479 SLMQLPTETIKAMDVSFENIRKFHAAQKEEKPLQVETIPGVVCSRFSRPPEAVGLYVPGG 538

Query: 135 SAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVFNVGGAQAIAALA 194
           +A L ST  ML  PA +A CKK+VL SPP                       + A+AA+A
Sbjct: 539 TAVLPSTAFMLGVPAMVAACKKIVLASPPR----------------------SDAVAAMA 576

Query: 195 FGTESVPKVDKIFGPGNAFVTEAKRQVSQRLD-GAAIDMPAGPSEVLVIADSGATPDFVA 253
           +GTESV KVDKI GPGN FVT AK  VS   + G  IDMPAGPSEVLVIAD  A P FVA
Sbjct: 577 YGTESVSKVDKILGPGNQFVTAAKMFVSNDTNAGVGIDMPAGPSEVLVIADKDANPAFVA 636

Query: 254 SDLLSQAEHGPDSQVILLTPAADMAR--RVAEAVERQLAELPRAETARQALNASRLIVTK 311
           SDLLSQAEHG DSQVIL+      A+   + + V +Q   LPR +  R ++  S  +  K
Sbjct: 637 SDLLSQAEHGVDSQVILIAIDLTDAQLLAIEDEVHKQAMALPRVDIVRGSIAHSLTVRVK 696

Query: 312 DLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPT 371
            + + +EISNQY PEHLI+Q ++A  +VD + +AGSVF+G+W+PES GDY++G NH LPT
Sbjct: 697 TVDEAMEISNQYAPEHLILQIKDAESVVDKVMNAGSVFIGEWTPESVGDYSAGVNHSLPT 756

Query: 372 YGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNALK 431
           YGY    S + LA F K +T   L+ EG   +   +  LA  E L AH+ AV++R+  + 
Sbjct: 757 YGYAKQYSGVNLASFVKHITSSNLTAEGLRNVGEAVMQLAKVEELEAHRRAVSIRLAHMD 816

Query: 432 E 432
           +
Sbjct: 817 Q 817


>UniRef50_Q3IQR5 Histidinol dehydrogenase n=10 Tax=Halobacteriaceae RepID=HISX_NATPD
          Length = 422

 Score =  463 bits (1191), Expect = e-129,   Method: Composition-based stats.
 Identities = 169/423 (39%), Positives = 237/423 (56%), Gaps = 11/423 (2%)

Query: 10  NSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVS 69
              + E +  L  R   +  E    +V DI+  V+  GD ALR Y+ +FD   +  L V+
Sbjct: 7   ADLSPEARAALFER--DAGIEDARESVRDIIGRVREEGDVALRSYAKEFDDVDIGTLAVT 64

Query: 70  AEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGL 129
            +E   A + L D+L+ A+  A +NI TFH  Q       E   G    +  RP+  VG+
Sbjct: 65  -DEAERAYDDLDDDLRDAIETAAENIRTFHERQVPDDWR-EQFDGRELGRRYRPLERVGV 122

Query: 130 YIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP--PIADEILYAAQLCGVQDVFNVGGA 187
           Y PGG+A   S+VLM   PA +AG   V + +PP   +    L AA + G   V+ VGGA
Sbjct: 123 YAPGGTAAYPSSVLMGVIPAVVAGVDHVAVATPPAEELPAATLAAAHVAGADAVYQVGGA 182

Query: 188 QAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGA 247
           QAIAALA+GTESV  V K+ GPGN +VT AK +V   ++   ID  AGPSE+LV+ D  A
Sbjct: 183 QAIAALAYGTESVSAVQKVVGPGNRWVTAAKAEVRGDVE---IDFLAGPSELLVVCDDTA 239

Query: 248 TPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNA--S 305
            P+ +A+D+++QAEH P++ V+ ++     A  VA+A ERQ     R E    AL    S
Sbjct: 240 DPELIAADMVAQAEHDPNASVVCVSDDEATAEAVADACERQATARERTEAIESALENDAS 299

Query: 306 RLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGT 365
            ++  + +++ V  + +Y  EHL I   +   L+D I SAGSVFLG +SP + GDYASGT
Sbjct: 300 AVLCARSMSEAVLFAEEYAAEHLSIVAADEEALLDRIDSAGSVFLGGFSPVAVGDYASGT 359

Query: 366 NHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTL 425
           NHVLPT G       L +  F +  TVQ+L ++  S+L  T+ TLA AE L AH  +V  
Sbjct: 360 NHVLPTGGLAKVAGGLSVDHFVRSTTVQKLDEDALSSLRETVTTLARAEGLEAHAESVDK 419

Query: 426 RVN 428
           R +
Sbjct: 420 RFD 422


>UniRef50_Q5JFR5 Histidinol dehydrogenase n=9 Tax=cellular organisms
           RepID=HISX_PYRKO
          Length = 376

 Score =  461 bits (1188), Expect = e-128,   Method: Composition-based stats.
 Identities = 151/401 (37%), Positives = 229/401 (57%), Gaps = 29/401 (7%)

Query: 30  ESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAMA 89
           + +   V +IL++++ RG EALREYS +FD  +    +VS  E   A E + +E K+ + 
Sbjct: 2   KGLEEYVREILEDIRRRGLEALREYSERFDNYS-GPFRVSEGEFEEAEELVPEEDKRVIE 60

Query: 90  VAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPA 149
             ++ +  +H  Q    V++  + G     + RP+  +G+Y+PGG  PL ST++M+  PA
Sbjct: 61  ETMERLWEYHARQ-FRDVELYIKRGSLYGLIYRPIGRIGIYVPGGK-PLPSTLMMVGIPA 118

Query: 150 SIAGCKKVVLCSPPP---IADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKI 206
            IAG +++ + +PP    +   +LY A+L G+++V+ +GG  AIAA+A+G   + +VDKI
Sbjct: 119 RIAGVREIAVTTPPKDGKVNPYVLYVAKLLGIEEVYKLGGVGAIAAMAYGV-GMRRVDKI 177

Query: 207 FGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDS 266
           FGPGN FV EAKRQV   +    ID  AGPSE+ VIAD  A  D+V +DLLSQ EHG DS
Sbjct: 178 FGPGNRFVNEAKRQVFGIV---GIDSLAGPSEIAVIADESADKDYVLADLLSQLEHGKDS 234

Query: 267 QVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQCVEISNQYGPE 326
           +  LLT + ++A               R            +++ ++L +C E +N+  PE
Sbjct: 235 KAWLLTTSRELAD-----------YCSREGI--------EVLLCRNLEECAEKANEIAPE 275

Query: 327 HLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADF 386
           HL I T N  ELVD I +AG+++LG ++P  A DY  G NHVLPT G       L + DF
Sbjct: 276 HLEIITENPEELVDLIENAGAIYLGPYTPVPAADYFLGVNHVLPTGGAARFSGVLTVMDF 335

Query: 387 QKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRV 427
            K +T+  +S+E F A       LA  E + AH+ ++ +R 
Sbjct: 336 MKPITLARVSREEFLAYRRLGMRLAEIEGMEAHRRSLEVRR 376


>UniRef50_C1FAE2 Histidinol dehydrogenase n=1 Tax=Acidobacterium capsulatum ATCC
           51196 RepID=C1FAE2_ACIC5
          Length = 428

 Score =  461 bits (1186), Expect = e-128,   Method: Composition-based stats.
 Identities = 166/433 (38%), Positives = 239/433 (55%), Gaps = 16/433 (3%)

Query: 4   NTIIDWNSCTAEQQRQLLMR---PAISASESITRTVNDILDNVKARGDEALREYSAKFDK 60
             ++      A+  +  L R    + ++ E        I+  V+  GD AL  Y AKFD 
Sbjct: 1   MRVLSTRGRGAQAAQDFLSRLLTGSEASYERALPAAQRIVQGVRRGGDAALLRYRAKFDG 60

Query: 61  -TTVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQ 119
                 L++ AEE+ AA +  + ELK A+  A KNI  F   Q+     ++  PGV   Q
Sbjct: 61  IAASEPLRIPAEEMEAAWKATTAELKAALKQAAKNIRRFAQKQRPRDFTLQMAPGVTAGQ 120

Query: 120 VTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQ 179
              P+ +VG Y+P G  PL ST+LM A PA +AG +++V  SP P A E L AA + GV 
Sbjct: 121 KVIPLEAVGCYVPSGRYPLPSTLLMTAIPAQVAGVRRIVAVSPRP-AKETLAAAHMLGVA 179

Query: 180 DVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEV 239
           + + +GGAQA+AALA+GT S+ +V KI GPGNA+VT AK+ VS       IDM AGP+E+
Sbjct: 180 EFYRIGGAQAVAALAYGTASIERVGKIVGPGNAYVTAAKKAVSFD---CGIDMLAGPTEI 236

Query: 240 LVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETAR 299
            VIA    T + +A+DL++QAEH PD+  IL+T  A + R VA   + +         A+
Sbjct: 237 -VIASENGTVEGIAADLVAQAEHDPDAIAILVTSNAALGRAVAAKTKLRAQS---NAIAK 292

Query: 300 QAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESA 358
           Q++     +I+T+D+ +   ++NQ   EHL   T ++   +  + +AGSVF+G WS +  
Sbjct: 293 QSIAANGAVILTRDVEEARMLTNQLAAEHL---TVDSSADLAWVRNAGSVFVGRWSSQPL 349

Query: 359 GDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTA 418
           GDY SG NH LPT G       L + D+ K +TVQE S  G   L  +   LA AE L  
Sbjct: 350 GDYVSGPNHTLPTSGLARLRGGLSVMDYLKLVTVQEYSATGVRQLGPSAVALAEAEGLVG 409

Query: 419 HKNAVTLRVNALK 431
           H +AV +R+ + K
Sbjct: 410 HADAVRVRLQSAK 422


>UniRef50_Q82AA6 Histidinol dehydrogenase n=29 Tax=Actinobacteridae RepID=HISX_STRAW
          Length = 441

 Score =  461 bits (1186), Expect = e-128,   Method: Composition-based stats.
 Identities = 149/425 (35%), Positives = 228/425 (53%), Gaps = 13/425 (3%)

Query: 12  CTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAE 71
                 R LL R     S ++ + V  I + V  RGD AL +++ KFD   + +++V A 
Sbjct: 13  PEGSALRDLLPRADFDVSAALEK-VRPICEAVHHRGDAALIDFAEKFDGVRLESVRVPAR 71

Query: 72  EIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYI 131
            +A A E+L   ++ A+  +++     H  Q+      +  PG    +   PV  VGLY 
Sbjct: 72  ALADALEQLDPAVRAALEESIRRARLVHREQRRTTHTTQVVPGGSVTEKWVPVDRVGLYA 131

Query: 132 PGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPI------ADEILYAAQLCGVQDVFNVG 185
           PGG +   S+V+M   PA  AG + + L SP            IL A  L GV +V+  G
Sbjct: 132 PGGRSVYPSSVVMNVVPAQEAGVESIALASPAQAEFGGLPHPTILAACALLGVDEVYAAG 191

Query: 186 GAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADS 245
           GA A+A  A+GTES    D + GPGN +V  AKR  + ++    ID  AGP+E+ V+ADS
Sbjct: 192 GATAVAMFAYGTESCAPADMVTGPGNIWVAAAKRYFTGKI---GIDAEAGPTEIAVLADS 248

Query: 246 GATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPR-AETARQALN- 303
            A P  VASDL+SQAEH P +  +L+T + ++A  V + +E Q+A      +    AL  
Sbjct: 249 TADPVHVASDLISQAEHDPLAAAVLVTDSVELADAVEKELEPQVAATKHIDDRIVPALKG 308

Query: 304 -ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYA 362
             S +++   + + + + + YG EHL IQT +A  + D + +AG++F+G W+P S GDYA
Sbjct: 309 RQSAIVLVDGVDEGLRVVDAYGAEHLEIQTADAAAVADRVRNAGAIFIGPWAPVSLGDYA 368

Query: 363 SGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNA 422
           +G+NHVLPT G     S L +  F + + + + +K+  + +A  + TLA AE L AH  A
Sbjct: 369 AGSNHVLPTGGCACHSSGLSVQSFLRGIHIVDYTKDALADVAHHVVTLAEAEDLPAHGAA 428

Query: 423 VTLRV 427
           +  R 
Sbjct: 429 IKARF 433


>UniRef50_C0GVA3 Histidinol dehydrogenase n=1 Tax=Desulfonatronospira thiodismutans
           ASO3-1 RepID=C0GVA3_9DELT
          Length = 436

 Score =  457 bits (1177), Expect = e-127,   Method: Composition-based stats.
 Identities = 132/408 (32%), Positives = 202/408 (49%), Gaps = 8/408 (1%)

Query: 29  SESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAM 88
           +  I   V  +LD+++ RG+ A+RE +AK+D  + T   +  E+       + +++K  +
Sbjct: 15  NSRIREAVTFLLDDIRTRGEPAVREMAAKYDGWS-TDFVLQEEKKERLIAMVPEQVKTDI 73

Query: 89  AVAVKNIETFHTAQKL--PPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLA 146
             A   +  F   Q+      +V   PGVR  Q   PV   G Y+PGG      + +M  
Sbjct: 74  RFAHDQVFNFARMQRQSIQDFEVRPHPGVRLGQRVLPVDVAGCYVPGGRFAHACSAIMSV 133

Query: 147 TPASIAGCKKVVLCSPP---PIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKV 203
             A  AG   VV CSPP    IA  + +A  L G   +  +GG Q +AA+A+G  +    
Sbjct: 134 ATAKAAGVPFVVACSPPREESIAPAVAFAMDLAGADVILELGGVQGVAAMAYGYFTNRPA 193

Query: 204 DKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHG 263
           D + GPGNA+V EAK  ++       ID+ AGP+E  +IAD  A P  +A DL+SQAEHG
Sbjct: 194 DILVGPGNAYVAEAKALLAGD-GTCGIDVYAGPTESAIIADRSADPMTIAIDLVSQAEHG 252

Query: 264 PDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVEISNQ 322
           PDS V L T   D+A +V   V R +A++P     + A  +   +I+  +  +   + + 
Sbjct: 253 PDSPVWLFTDCRDLAYQVLNLVPRVIADMPDPHVPKTAWADFGEIILCNNRDEICRVCDT 312

Query: 323 YGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLG 382
           Y PEH+ I   +    ++S+ S GS+FLG+ S  + GD  SGTNH+LPT         L 
Sbjct: 313 YAPEHVQILAADPDWWLESLRSYGSLFLGEGSSVAHGDKCSGTNHILPTRKAAQHSGGLS 372

Query: 383 LADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNAL 430
           +  F K  T QE+  E     ++    L+  E +  H  +   R+   
Sbjct: 373 VHKFLKISTYQEIDTEASKRFSAVASRLSRVEGMEGHARSCDWRLTKF 420


>UniRef50_Q5YYQ0 Histidinol dehydrogenase n=8 Tax=Actinomycetales RepID=HISX_NOCFA
          Length = 445

 Score =  456 bits (1175), Expect = e-127,   Method: Composition-based stats.
 Identities = 159/437 (36%), Positives = 233/437 (53%), Gaps = 17/437 (3%)

Query: 7   IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTAL 66
           +   + +  + R  L R  +    S+   V  +++ V+ RG  A  E+  KFD      +
Sbjct: 12  LRGRTPSTAELRAALPRGGVDVD-SVLHHVRPVVEAVRERGAAAALEFGEKFDGVVPATV 70

Query: 67  KVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVAS 126
           +V A E+A A + L   ++ A+  ++      H  Q+      E  PG    +   PVA 
Sbjct: 71  RVPAAELARALDELDPAVRAALEESIARARRVHADQRRTDTTTEVVPGGTVTERWVPVAR 130

Query: 127 VGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPI------ADEILYAAQLCGVQD 180
           VGLY+PGG+A   S+V+M   PA  AG   +V+ SPP           IL AA L GV++
Sbjct: 131 VGLYVPGGNAVYPSSVVMNVVPAQTAGVGSLVVASPPQANFGGLPHPTILAAAALLGVEE 190

Query: 181 VFNVGGAQAIAALAFG---TESVP--KVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAG 235
           V+ VGGAQA+A L++G   T+  P   VD I GPGN +VT AKR     +    ID  AG
Sbjct: 191 VWAVGGAQAVALLSYGGTDTDGAPLDPVDLITGPGNIYVTAAKRLCRGLV---GIDAEAG 247

Query: 236 PSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRA 295
           P+E+ ++AD+ A P  VA+DL+SQAEH   +  +L+T +  +A  V  A+  QLA +  A
Sbjct: 248 PTEIAILADATADPAHVAADLISQAEHDVLAASVLVTDSVALADAVDAALTAQLAVVKHA 307

Query: 296 ETARQAL--NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDW 353
           E  R AL    S  ++  D+ Q + + + Y  EHL IQT +A  +   + SAG+VF+G +
Sbjct: 308 ERVRTALTGKQSGTVLVDDITQGLRVVDAYAAEHLEIQTADASAVAARVRSAGAVFVGPY 367

Query: 354 SPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAA 413
           +P S GDY +G+NHVLPT G     S L +  F + + V E ++     +A  +  LA A
Sbjct: 368 APVSLGDYCAGSNHVLPTAGCARHSSGLSVQTFLRGIHVVEYTEAALKDVAGHVVALADA 427

Query: 414 ERLTAHKNAVTLRVNAL 430
           E L AH  AVT+R  AL
Sbjct: 428 EDLPAHGQAVTVRFEAL 444


>UniRef50_Q1D4L9 Histidinol dehydrogenase n=2 Tax=Cystobacterineae
           RepID=Q1D4L9_MYXXD
          Length = 437

 Score =  456 bits (1173), Expect = e-126,   Method: Composition-based stats.
 Identities = 172/423 (40%), Positives = 243/423 (57%), Gaps = 9/423 (2%)

Query: 9   WNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKV 68
            ++   E  R+LL R A  +   +   V +I+  V+A GD+AL E + +FD+  +TAL+V
Sbjct: 16  LSALAREDVRRLLDR-ATGSDARVALRVREIIARVRAEGDQALFELARQFDRVELTALEV 74

Query: 69  SAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVG 128
             E  AAA   L   ++ A+A A +NI   H  QK   V+VET+PGV   +   P+  VG
Sbjct: 75  PREVCAAALAGLEPSVRDALARAARNIALAHAPQKPQWVEVETEPGVLVGRRPDPLGRVG 134

Query: 129 LYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQDVFNV 184
           +Y PGG A   S+VLM   PA +AG  +V++CSPP         +L AA L G   VF++
Sbjct: 135 VYAPGGRAVYPSSVLMGVVPAKVAGVGEVIVCSPPGPDGLPHPSVLAAASLAGADRVFSL 194

Query: 185 GGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIAD 244
           GGA A+AA+A GTESVP+VD+I GPGNA+V EAK QV   +   AI+ PAGPSE+LV+AD
Sbjct: 195 GGAGAVAAMAHGTESVPRVDRIVGPGNAYVAEAKLQV---VGAVAIEAPAGPSEILVVAD 251

Query: 245 SGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-N 303
             A P  VA ++L+QAEH P++  + L     +A  +A  VERQ     R E    AL +
Sbjct: 252 DTANPAAVAREMLAQAEHDPEAACVTLALGDALADAIAAEVERQAERAKRWEIVTSALGS 311

Query: 304 ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYAS 363
              ++    L +       + PEHL+I T + RE +  + +AG+VFLG+ S  + GDY +
Sbjct: 312 RGAVLTVASLEEAWPFVADFAPEHLLIATASPREDLGQVRNAGTVFLGERSSVAYGDYMT 371

Query: 364 GTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAV 423
           G+NHVLPT G     S L L DF +  T Q ++    ++LA  +  LA +E L AH +A 
Sbjct: 372 GSNHVLPTAGLARAYSGLNLLDFYRWTTYQRVAPTAAASLAEDVGRLADSEGLFAHADAA 431

Query: 424 TLR 426
              
Sbjct: 432 RAW 434


>UniRef50_B8E2C3 Histidinol dehydrogenase n=1 Tax=Dictyoglomus turgidum DSM 6724
           RepID=B8E2C3_DICTD
          Length = 417

 Score =  455 bits (1171), Expect = e-126,   Method: Composition-based stats.
 Identities = 126/411 (30%), Positives = 214/411 (52%), Gaps = 19/411 (4%)

Query: 21  LMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA--LKVSAEEIAAASE 78
           L+R   S  + + + V+ I++ ++ +GD AL  +S KFD         K+S  EI     
Sbjct: 14  LLRMEESKVKEVEKEVDFIVEEIRTKGDLALHNFSLKFDNYDSKKYGFKISVPEID---- 69

Query: 79  RLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPL 138
            LS++   A+ V ++ ++ ++  +       +    +   Q+  PV SV LY+PGG A  
Sbjct: 70  -LSNDFATAIKVMIERVKNYYIHEYKNSWFYKDGESI-LGQLIVPVDSVLLYVPGGKASY 127

Query: 139 FSTVLMLATPASIAGCKKVVLCSPPPI--ADEILYAAQLCGVQDVFNVGGAQAIAALAFG 196
            STV+M   PA IAG K + + +PP       +LY  +L G+++++ +GGA AI+A A+G
Sbjct: 128 PSTVVMGLIPAMIAGVKNLYVTTPPSKREDRNLLYTLRLLGIKELYVLGGAHAISAFAYG 187

Query: 197 TESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIAD---SGATPDFVA 253
           TES+PKVD I GPGN +V  AK++V   ++   ID   GPSE+LV  +          + 
Sbjct: 188 TESIPKVDMIIGPGNLYVALAKKRVFGDVN---IDGIFGPSEILVWINYRGKDLNLRKIV 244

Query: 254 SDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDL 313
            D L+Q EH P  +  ++ P  ++  +V   ++ ++    R +  ++A+  S LI+ +D 
Sbjct: 245 CDFLAQLEHSPYDRGWMILP-EELLDKVMGLIKEEVEGSGRGDILKEAIKNSFLIIEEDE 303

Query: 314 AQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYG 373
            + + + NQ  PEHL I   +    +  I +AG++F+   S    GD+ +G +H+LPT G
Sbjct: 304 ERAINLINQIAPEHLEIIDFSGERHIPYIKNAGAIFINHSS--IFGDFIAGPSHILPTGG 361

Query: 374 YTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVT 424
                S L +  F KR++  +LS +    LA     +A  E    H+ ++ 
Sbjct: 362 SAKFSSGLSVNSFLKRISFVKLSAKEQKILAEYGSIIAREEGFYMHEKSLR 412


>UniRef50_B5YE85 Histidinol dehydrogenase n=1 Tax=Dictyoglomus thermophilum H-6-12
           RepID=B5YE85_DICT6
          Length = 416

 Score =  454 bits (1170), Expect = e-126,   Method: Composition-based stats.
 Identities = 127/428 (29%), Positives = 216/428 (50%), Gaps = 23/428 (5%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              +I              +R   S  + I + V  I++ VK +GD AL ++S ++D   
Sbjct: 1   MINVIRGKDFDPN-----FLRIEDSKIKEIEKNVEFIIEEVKTKGDLALYDFSLRYDNYD 55

Query: 63  VTA--LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQV 120
                 K++  +I      LS +   A+ V ++ ++ ++  +       +    +   Q+
Sbjct: 56  SRKYGFKINVPDID-----LSTDFAVAIKVMIERVKNYYMHEYKNSWFYKDGESIF-GQL 109

Query: 121 TRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPI--ADEILYAAQLCGV 178
             PV SV LY+PGG A   STV+M   PA IAG K + + +PP       +LY  ++ G+
Sbjct: 110 VVPVDSVLLYVPGGRASYPSTVVMGLVPAIIAGVKNLYVTTPPSKRDDKNLLYTLRILGI 169

Query: 179 QDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSE 238
           ++++ +GGA AI+A A+GTES+PKVD I GPGN +V  AK++V   ++   ID   GPSE
Sbjct: 170 KELYLLGGAHAISAFAYGTESIPKVDMIIGPGNLYVALAKKKVFGDVN---IDGIFGPSE 226

Query: 239 VLVIA--DSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAE 296
           VLV    D       V  D L+Q EH P  +  ++  + ++   + E +++++ +  R +
Sbjct: 227 VLVWVNYDKDLNLRKVVCDFLAQLEHSPYDRGWIIV-SENLVYDLLELIKKEVEDSERGD 285

Query: 297 TARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPE 356
             +++L  S LI+ ++    + + NQ GPEHL I        +  I +AG++F+   S  
Sbjct: 286 ILKESLKNSFLIIEENEKNAINLINQIGPEHLEIIDPFGERYIPYIKNAGAIFINHSS-- 343

Query: 357 SAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERL 416
             GD+ +G +H+LPT G     S L +  F KR++  +LS +    LA    T+A  E  
Sbjct: 344 IFGDFIAGPSHILPTGGSAKFSSGLSVNSFLKRISFVKLSTQDQKILAKYGSTIAREEGF 403

Query: 417 TAHKNAVT 424
             H+ ++ 
Sbjct: 404 YMHEKSLR 411


>UniRef50_O33775 Histidinol dehydrogenase n=12 Tax=Sulfolobaceae RepID=HISX_SULSO
          Length = 398

 Score =  450 bits (1158), Expect = e-125,   Method: Composition-based stats.
 Identities = 139/412 (33%), Positives = 219/412 (53%), Gaps = 23/412 (5%)

Query: 21  LMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERL 80
           L     +    +   V DI+++VK +GD AL E + K DK  +  +K   EE+   + +L
Sbjct: 6   LPNERPNDFSRVIPVVKDIIESVKTKGDNALYELTEKLDKVKIDNIKAREEELKTQASKL 65

Query: 81  SDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFS 140
             ++KQA+  A + ++ FH     P +      G+    + R +  +G+Y+P G     S
Sbjct: 66  DPKVKQAIDTAYEQLKAFHEMLVPPNI-GGGYQGISFGVIWRSIEKIGIYVPSGKYSYPS 124

Query: 141 TVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQDVFNVGGAQAIAALAFG 196
           T+LM   PA +A  K++ + SPP     +   + Y A   GV +V+ +GGAQAIAALAFG
Sbjct: 125 TLLMAGIPAKVAKVKEIYVASPPTQEGTVNPALAYVAIKLGVNEVYKIGGAQAIAALAFG 184

Query: 197 TESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDL 256
           TESV KV KI GPGN +V  AK  VS  +    ID   GP+E+++IAD  A  ++VA D+
Sbjct: 185 TESVKKVYKIVGPGNVYVQAAKYLVSSVV---GIDGIEGPTELVIIADETAKAEYVALDM 241

Query: 257 LSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQC 316
            +QAEHGPD+ ++LL+   ++ RRV E +             +       +I TK+L + 
Sbjct: 242 KAQAEHGPDTYIVLLSNDDELIRRVEEKI-------------KNDKKIYYIIKTKNLDEA 288

Query: 317 VEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTA 376
           +EI+N+  PEHL +  ++A  L+D I +AG++ LG+ +P +  DY +G NH+LPT G+  
Sbjct: 289 IEIANKIAPEHLSLYVKDAYTLMDKIVNAGAISLGN-TPPAIIDYVAGPNHILPTNGWAK 347

Query: 377 TCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVN 428
               + + DF K      + ++    L     +LA  E    H  ++  R  
Sbjct: 348 IRGGITVYDFIKPTMYANV-RDINKQLLEASISLANYEGFIIHGKSIGARYE 398


>UniRef50_Q1IKB6 Histidinol dehydrogenase n=1 Tax=Candidatus Koribacter versatilis
           Ellin345 RepID=Q1IKB6_ACIBL
          Length = 415

 Score =  445 bits (1146), Expect = e-123,   Method: Composition-based stats.
 Identities = 177/426 (41%), Positives = 250/426 (58%), Gaps = 16/426 (3%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKT-T 62
             I+     +       L    ++ +  +   V  I+ +V+  GD ALR Y++K D    
Sbjct: 1   MRILRLEKSSG--LLAKLAARGMADASRVEPVVRKIVVDVRKNGDAALRRYASKLDGLGK 58

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
             AL+VS EE+ +A +    E KQA+  A KNIE F   Q       +   G+   Q+ R
Sbjct: 59  TAALRVSTEELKSAWDATRSEFKQAIRAAAKNIERFARWQMPKSWTRDAGDGIELGQIIR 118

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVF 182
           P+ SVG Y+PGG  PL STVLM   PA +AG ++VV+ SP P A E L AA L GV + +
Sbjct: 119 PIESVGCYVPGGRYPLPSTVLMTVVPARVAGVERVVVVSPNP-ARETLAAAYLLGVGEFY 177

Query: 183 NVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVI 242
            +GGAQA+AALA+GTESV +V KI GPGN FVT AK+ V+      AIDM AGP+E  ++
Sbjct: 178 RIGGAQAVAALAYGTESVERVAKIVGPGNIFVTTAKKLVAFD---CAIDMLAGPTEAAIV 234

Query: 243 ADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL 302
           +       F+A+DL++QAEH P++ V   T +  +A  V + V    A   +   AR+AL
Sbjct: 235 S-ERGNARFIAADLVAQAEHDPETMVAFFTTSPSLADAVKKQVALLAA---KNTIARKAL 290

Query: 303 N-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDY 361
                + V +D+AQ +E +NQ+  EHL +      +L+++++SAGSVF+GD+S +S GDY
Sbjct: 291 ATRGYIFVAQDIAQAMEAANQFASEHLTVD----EDLLETVSSAGSVFVGDYSAQSFGDY 346

Query: 362 ASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKN 421
           ASG NHVLPT G       L + D+ K +TVQ++S++G  ALA   ETLAAAE L AH  
Sbjct: 347 ASGPNHVLPTGGLARVRGGLSVLDYVKIITVQKISRKGLRALAPIAETLAAAEGLVAHGQ 406

Query: 422 AVTLRV 427
           +V +R 
Sbjct: 407 SVAIRR 412


>UniRef50_Q46N53 Histidinol dehydrogenase 2 n=50 Tax=root RepID=HISX2_RALEJ
          Length = 436

 Score =  444 bits (1144), Expect = e-123,   Method: Composition-based stats.
 Identities = 136/418 (32%), Positives = 213/418 (50%), Gaps = 13/418 (3%)

Query: 22  MRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLS 81
            +   + + +  + V ++L  ++ARG +A+R+Y+ + D  +   + ++ ++I   ++ + 
Sbjct: 9   EKTPQTETATAQKVVTEMLAEIQARGKDAVRQYAKQLDGWS-GDIVLTPDQIREQTKDVP 67

Query: 82  DELKQAMAVAVKNIETFHTAQKL--PPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLF 139
             ++  +  A++ +  F  AQ+       VE  PGV   Q   PV  VG Y P G     
Sbjct: 68  AGVRADIDFAIRQVTDFALAQRESLKEFSVELHPGVTAGQRVLPVNVVGCYAPAGRYAHI 127

Query: 140 STVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQDVFNVGGAQAIAALAF 195
           ++  M    A  AG K VV CS P     I   +LYA Q  G   +  +GG QAIA++A+
Sbjct: 128 ASAYMGVATAKAAGVKTVVACSSPFRGQGIHPHVLYAFQAAGADVIMALGGVQAIASMAY 187

Query: 196 GTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASD 255
           G  +    D + GPGN FV EAKR +  ++    ID+ AGPSEV VIAD  A P  VASD
Sbjct: 188 GLFTGKPADVVVGPGNKFVAEAKRSLYGQV---GIDVFAGPSEVAVIADETADPAIVASD 244

Query: 256 LLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPR--AETARQAL-NASRLIVTKD 312
           L+ QAEHG +S   L T + D+A RV   V   +A+LP    + A  A  +   +I+   
Sbjct: 245 LVGQAEHGHESPAWLFTTSRDLADRVMALVPELIAKLPPTARDAATAAWRDYGEVILCGT 304

Query: 313 LAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTY 372
             + VEIS++Y  EHL + T +    + ++T  GS+FLG+ +  + GD  SG NHVLPT 
Sbjct: 305 REEVVEISDRYASEHLEVHTADLDWWLANLTCYGSLFLGEETTVAFGDKTSGPNHVLPTK 364

Query: 373 GYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNAL 430
           G       L +  F K +T Q++++E    +      ++  E + AH      R+   
Sbjct: 365 GAARYSGGLSVHKFMKTLTWQQMTREATRQIGQVTARISRLEGMEAHARTADDRMAKY 422


>UniRef50_C7LZ86 Histidinol dehydrogenase n=1 Tax=Acidimicrobium ferrooxidans DSM
           10331 RepID=C7LZ86_ACIFD
          Length = 432

 Score =  441 bits (1134), Expect = e-122,   Method: Composition-based stats.
 Identities = 156/434 (35%), Positives = 223/434 (51%), Gaps = 9/434 (2%)

Query: 1   MSFNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDK 60
           M+  T++D    T   +R  L        E     V +I+ +V+  GD AL + + +FD 
Sbjct: 1   MASLTLVDLRETTGALRRDDLP-GVALPVEGPRALVREIVQSVRTGGDGALADLTERFDG 59

Query: 61  TTVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQV 120
               AL +  E +AAA ERL   L +A+ VA   +   + A++     +    G+  ++ 
Sbjct: 60  VRPRALVLGREAMAAAYERLDRRLAEALRVARDRVREAYEAERPAASSL-VADGIEVRRR 118

Query: 121 TRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLC 176
             PV   G Y+PGG A   S+V+  AT A +AG + VV+ +PP     + D  L A  L 
Sbjct: 119 IVPVERAGCYVPGGQARYPSSVVHTATVARVAGVRDVVVATPPLPDGGLDDATLAACHLA 178

Query: 177 GVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGP 236
           GV  V   GGAQA+AALA+GTES+ +VD I GPGN FV+ AK++V+  +        AGP
Sbjct: 179 GVDTVLLAGGAQAVAALAYGTESLERVDVIVGPGNLFVSLAKQEVAADVGVPG--AFAGP 236

Query: 237 SEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAE 296
           SEV+V+AD    P   A D+  QAEHGP     L+T  A  A +V E +   +   PR  
Sbjct: 237 SEVVVVADGSLEPRVAAIDVAVQAEHGPHGLAWLVTWDARWAEQVLEELAAYVEASPRRA 296

Query: 297 TARQALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSP 355
                L     L + +D  Q   +++   PEHL +    A    D +  AG VF+G  + 
Sbjct: 297 QLESTLEAHGYLALVRDRDQARLVADAIAPEHLELLYDQAVRDADRVRHAGVVFVGRAAS 356

Query: 356 ESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAER 415
            + GDY +G +HVLPT G     S LGL DFQ+R+ V E+  E  S L   +E LA AE 
Sbjct: 357 AAFGDYVAGPSHVLPTAGTARFASVLGLEDFQRRLHVVEVHDEALSRLGWAVEALADAEG 416

Query: 416 LTAHKNAVTLRVNA 429
           L AH +++ +R  A
Sbjct: 417 LVAHADSIRIRREA 430


>UniRef50_A9G5W4 HisD protein n=1 Tax=Sorangium cellulosum 'So ce 56'
           RepID=A9G5W4_SORC5
          Length = 460

 Score =  438 bits (1128), Expect = e-121,   Method: Composition-based stats.
 Identities = 164/451 (36%), Positives = 226/451 (50%), Gaps = 28/451 (6%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              I    S   E     L         ++T  V +I+DNV+  G  A+  Y  KF++ T
Sbjct: 1   MLPIYIEGSPQFESTLSALRTRGTGDLANVTPAVTEIIDNVRRGGTSAVLGYIEKFERRT 60

Query: 63  VTAL-KVSAEEIA------AASERLSDELKQAMAVAVKNIETFHTAQK------------ 103
             AL + +  E         A  RLS E++ A+  A   I  +H  Q+            
Sbjct: 61  SKALVRHAGPEAEGGFGGAEALARLSPEVRAALETAAARIARYHERQRDAGDLGPANVTA 120

Query: 104 ----LPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVL 159
               L       + GV      RP+  VG+Y PGG A   S+VLM A PA IAG +++VL
Sbjct: 121 NGPALQAGFSYEEEGVLLGMRVRPLRRVGVYAPGGKARYPSSVLMSAIPARIAGVREIVL 180

Query: 160 CSPPPIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKR 219
            SP    D  L AA L GV  + + GGAQAIAA+A+G   +  VDKI GPGNA+V  AK+
Sbjct: 181 ASP-SADDATLAAAHLSGVTTLLDSGGAQAIAAMAYGLPELAPVDKIVGPGNAYVACAKK 239

Query: 220 QVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMAR 279
            V   +   +ID   GPSE+L +AD  A P  VA+DLLSQAEH   S  +L T +A +A 
Sbjct: 240 LVFGDV---SIDGITGPSEILALADESADPRLVAADLLSQAEHDEASYALLATTSAKLAE 296

Query: 280 RVAEAVERQLAELPRAETARQALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNAREL 338
            VA  ++  L EL R    + +L+  +  +V    A+  EI++Q   EH+     +A  L
Sbjct: 297 AVARELDAALPELTRRAIVQASLSTHAAALVVGSRARLAEIADQLAVEHVAFHVADAEGL 356

Query: 339 VDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKE 398
              I + G+  LGD +P +AGDY +G +HVLPT G     + LG+ DF  R ++   S  
Sbjct: 357 FSEIGTLGAALLGDLTPVAAGDYLAGPSHVLPTGGSARFGAPLGVYDFVTRASLIRYSSA 416

Query: 399 GFSALASTIETLAAAERLTAHKNAVTLRVNA 429
              A    IE LA AE L AH  AV+LR+ +
Sbjct: 417 ALRAQGPIIEKLALAEGLQAHARAVSLRLAS 447


>UniRef50_Q0AP81 Histidinol dehydrogenase, Histidinol-phosphatase n=10 Tax=Bacteria
           RepID=Q0AP81_MARMM
          Length = 631

 Score =  436 bits (1123), Expect = e-121,   Method: Composition-based stats.
 Identities = 188/434 (43%), Positives = 259/434 (59%), Gaps = 6/434 (1%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              I++W   + E + + L RPA S+S        DI+D ++ +GDEA+R Y+ + D   
Sbjct: 1   MLDILNWTDASPEARTRALTRPASSSSAGPAA--RDIVDAIRDQGDEAVRAYAKRLDGYA 58

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
               +V    + AA   L     +A+  A   +  FH  Q      VET PGV   +   
Sbjct: 59  PGDFRVPEGVLKAARAALDPRDAEAIKAAADAVRRFHVQQGYRGYSVETWPGVTASRRAT 118

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGV 178
           PV +  LY+P GSAPL S+++MLA PA +AG  ++V+ +PP     +   +L AA L G+
Sbjct: 119 PVDTAALYVPAGSAPLVSSLIMLAIPAQLAGVPRIVVVAPPAGDGGVNPALLAAADLLGL 178

Query: 179 QDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSE 238
            +V+ +GGAQAIAAL+FG   +P+ DKIFGPGNA+V  AK  VS    G A+D+PAGPSE
Sbjct: 179 DEVYAIGGAQAIAALSFGAAGLPRADKIFGPGNAYVAAAKAYVSSLPGGPAVDLPAGPSE 238

Query: 239 VLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETA 298
           V+VIAD  A PD VASDLLSQAEH P +QV+L+   A  A RV  +V + L +LPRA  A
Sbjct: 239 VMVIADETADPDLVASDLLSQAEHDPSAQVMLVCFDAATADRVTASVAKLLEDLPRAAIA 298

Query: 299 RQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESA 358
           R+AL AS ++V   +   ++I+N Y PEHLI+Q  +A  L+  +  AGS+F+G W+PE+A
Sbjct: 299 REALAASAILVCDSVDDAIDIANIYAPEHLILQAESAERLLAGVRHAGSIFVGAWTPEAA 358

Query: 359 GDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTA 418
           GDYA+G NH LPT G       + +  FQK  T+   S+ G  ALA T+E LAA E+L A
Sbjct: 359 GDYAAGPNHTLPTAGAARAHGGVSVESFQKTTTILRASEAGAVALAPTVERLAALEQLDA 418

Query: 419 HKNAVTLRVNALKE 432
           H  A+ LR      
Sbjct: 419 HGLAMRLRRERANT 432


>UniRef50_A0R401 Histidinol dehydrogenase n=2 Tax=Actinomycetales RepID=A0R401_MYCS2
          Length = 451

 Score =  431 bits (1109), Expect = e-119,   Method: Composition-based stats.
 Identities = 152/419 (36%), Positives = 228/419 (54%), Gaps = 12/419 (2%)

Query: 24  PAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDE 83
           P       +   V+ +L +++ RG +A+R Y+ + D  +   L++ A+E+  + + L  +
Sbjct: 25  PPAQRDPKVVERVSQMLLDIERRGLDAVRAYARELDGWS-GPLEIGADELRKSGDALPAD 83

Query: 84  LKQAMAVAVKNIETFHTAQKLP--PVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFST 141
           L++A+ +  +    F  AQ+      ++E  PGV       PV  VG Y+P G  PL ++
Sbjct: 84  LREALELGYERTNRFAVAQRARLTDFEIELAPGVTGGVQYVPVNRVGAYLPAGRFPLLAS 143

Query: 142 VLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQDVFNVGGAQAIAALAFGT 197
             M    A  AG   V+ C+PP         +LY A L     VF VGG QA+ A+AFG 
Sbjct: 144 AFMTVGVAKAAGVPTVLACTPPSGEHGAHPAVLYGAYLSRADSVFAVGGVQALGAMAFGL 203

Query: 198 ESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLL 257
                VD + G GNAFVTEAKRQ+  R+    ID+ AGPSEV V+AD  A P++VA+DLL
Sbjct: 204 IGDGPVDMLVGAGNAFVTEAKRQLFGRV---GIDLLAGPSEVAVLADETADPEWVAADLL 260

Query: 258 SQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQC 316
            QAEHGP+S   L+T +  + RRV EA++RQL  L   E A  A  +   ++V  D  Q 
Sbjct: 261 GQAEHGPNSPAALITTSETLGRRVIEAIDRQLETLATREVAGPAWRDFGSVLVASDAEQA 320

Query: 317 VEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDY-ASGTNHVLPTYGYT 375
             I++  GPEHL +QT +    +  + + GS+FLG WS  +  D   +GTNHVLPT    
Sbjct: 321 AAIADVLGPEHLEVQTADDDYFLKRLRNYGSLFLGRWSTVAYSDKGIAGTNHVLPTGKTA 380

Query: 376 ATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNALKEQA 434
              + L ++ F K +T Q  ++E  +ALA  +E ++A E L AH+   T+R+  +   +
Sbjct: 381 RYNAGLSVSRFVKPLTYQRAAREATAALAPAVERISAFEGLAAHEATATIRIEEIGRDS 439


>UniRef50_C7RAI8 Histidinol dehydrogenase n=1 Tax=Kangiella koreensis DSM 16069
           RepID=C7RAI8_KANKD
          Length = 405

 Score =  426 bits (1097), Expect = e-118,   Method: Composition-based stats.
 Identities = 134/421 (31%), Positives = 216/421 (51%), Gaps = 22/421 (5%)

Query: 10  NSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVS 69
              +  +      RP ++ S  + + V  +L  ++  GD A+   S +FD      +++ 
Sbjct: 2   ADKSYIECASNWKRPNLTQSPELFQQVAKLLKEIETGGDLAIDNLSKRFDGFQPRKIELR 61

Query: 70  AEEIAAASERLSDELKQAMAVAVKNIETFHTAQK--LPPVDVETQPGVRCQQVTRPVASV 127
                     L  +L  ++  A + IE F   QK  L P  +E   GV   Q   P+ ++
Sbjct: 62  PYRDYE----LEPQLLNSIEQAAQRIEAFCQLQKGSLQPQQIEEASGVFGFQ-YSPIEAI 116

Query: 128 GLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVFNVGGA 187
           G YIPGG  PL ST LM   PA +AGC++ V CSP  +   IL AA L G  + + +GGA
Sbjct: 117 GAYIPGGRFPLISTALMTLIPARVAGCQRRVACSP-SVHPAILAAASLAGATEFWQIGGA 175

Query: 188 QAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGA 247
           QA+AA+A+G +++  V  + GPGN +V  AK+ +  R+    ID+ AGPSE+L++ADS A
Sbjct: 176 QAVAAMAYGYQTMLPVQMVVGPGNQYVNVAKQLLQSRIK---IDVAAGPSELLILADSNA 232

Query: 248 TPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAV--ERQLAELPRAETARQALNAS 305
             +++ +D+ +QAEH P +Q +L++      + + + +    +L  L + E         
Sbjct: 233 NQEWLIADMAAQAEHDPQAQSVLVSDDIAFLQSIGQQLTANDELNNLLKGEQI------- 285

Query: 306 RLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGT 365
            L+   D    +  SN+Y PEHL++   + R    S+   GS+F+G  S  + GDY +G 
Sbjct: 286 VLLQANDCEAMIRFSNRYAPEHLLL--ADERIASQSLKHYGSLFIGQNSAVAFGDYCAGP 343

Query: 366 NHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTL 425
           NH LPT G     S L +  F    + Q+++ +G   LA     LA AE+L  H+ ++ +
Sbjct: 344 NHTLPTMGSANRSSGLCVQSFMNIQSYQQINDQGRIQLAEIGRPLAEAEQLVWHERSMQV 403

Query: 426 R 426
           R
Sbjct: 404 R 404


>UniRef50_B1ZNB2 Histidinol dehydrogenase n=3 Tax=Verrucomicrobia RepID=B1ZNB2_OPITP
          Length = 431

 Score =  424 bits (1090), Expect = e-117,   Method: Composition-based stats.
 Identities = 152/433 (35%), Positives = 233/433 (53%), Gaps = 14/433 (3%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
             I+   S T +       R  +     IT +V  IL +V+ RGDEA+  Y+AKFD   +
Sbjct: 1   MRILHHASKTFDADVADFCRTTM-VPREITESVAAILADVRERGDEAVVYYAAKFDGAKL 59

Query: 64  T--ALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVT 121
               L+V   ++  A++RL    ++A+  A  +I  ++          +   G    +  
Sbjct: 60  RARDLRVKPSDLTVAAKRLPAAERRALVAARDSIMDYNRRGLPRGWTAKNPHGAMVGEKF 119

Query: 122 RPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSP----PPIADEILYAAQLCG 177
            P+  VGLY+PGG  PL STVLM  T A IA C +VV+ +P      IAD +L A  L G
Sbjct: 120 DPLRRVGLYVPGGQVPLVSTVLMTVTLAKIAQCPQVVVFTPCNAEGKIADGLLAALHLLG 179

Query: 178 VQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPS 237
           V +V+ VGG QAI A+AFGT ++P VDKIFGPGNA+  EA RQV   +    ++   GPS
Sbjct: 180 VDEVYRVGGVQAIGAMAFGTTTIPPVDKIFGPGNAYTCEAMRQVFGIV---GVNGLPGPS 236

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPD-SQVILLTPAADMARRVAEAVERQLAELPRAE 296
           E++VIAD  A  D+ A+DLL+QAEHG    +V L+  ++ +   +   +  QL  L R+E
Sbjct: 237 ELMVIADDTARADYAAADLLAQAEHGSGREKVYLVATSSRVITEIVNEMNGQLQTLTRSE 296

Query: 297 TARQALNASRL-IVTKDLAQCVEISNQYGPEHLIIQTRNA--RELVDSITSAGSVFLGDW 353
             ++ L    L I    + Q   ++N   PEHL +    A  ++L  ++T+AG++ +G+ 
Sbjct: 297 KTQRVLEQGFLAIEVGSMQQAAAVANYVAPEHLELLVSEAAVKQLTKAVTTAGAIMIGNE 356

Query: 354 SPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAA 413
           +P + GD+ +G +HVLPT       S + ++DF +R ++    ++     A  +   AA 
Sbjct: 357 TPTALGDFTAGPSHVLPTGRAGRFFSGMRVSDFLRRTSLVRYDRKSVRKGAPVVAAFAAM 416

Query: 414 ERLTAHKNAVTLR 426
           ERL AH  +V +R
Sbjct: 417 ERLDAHGRSVKIR 429


>UniRef50_C1A4M1 Histidinol dehydrogenase n=1 Tax=Gemmatimonas aurantiaca T-27
           RepID=C1A4M1_GEMAT
          Length = 816

 Score =  419 bits (1079), Expect = e-116,   Method: Composition-based stats.
 Identities = 154/430 (35%), Positives = 237/430 (55%), Gaps = 15/430 (3%)

Query: 8   DWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALK 67
            W+      +R L  R A +   +I    + ++D V+  GD AL + + +FD  T+  L+
Sbjct: 12  SWDRLDNATRRALEDR-ASTVDPTIRERTSAVIDAVRRTGDAALIDMARRFDGATLETLE 70

Query: 68  VSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASV 127
           V   E   A   L   L+Q++  A +NI T H A          +PG+   +   P+  V
Sbjct: 71  VPRAEWDRALAALDPALRQSLERAARNIATVHRAFLPTITRSTPEPGITVVRRPDPLGRV 130

Query: 128 GLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIAD----EILYAAQLCGVQDVFN 183
           G+Y PGG A   S++LM A PA +AG  ++++C+PP         +L AA L  V  VF 
Sbjct: 131 GIYAPGGRAAYPSSLLMGAVPARVAGVGEIIVCTPPGPDGRPADVVLAAAALANVDRVFA 190

Query: 184 VGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIA 243
           VGGA AIAA+A GT SVP+VD+I GPGNA+V EAK Q+   +   AID PAGPSE+LV+A
Sbjct: 191 VGGAGAIAAMALGTASVPRVDRIMGPGNAYVAEAKLQL---VSAVAIDAPAGPSELLVLA 247

Query: 244 DSGATPDFVASDLLSQAEHGPDSQVILLTPA----ADMARRVAEAVERQLAELPRAETAR 299
           D+ A  + +A ++L+QAEH PD+ V+ +       + +A RV  A++ QLA  PRA+  R
Sbjct: 248 DASADANTIAREMLAQAEHDPDAAVLAVIVDHSATSSLATRVETALQTQLASAPRADVMR 307

Query: 300 QALNA-SRLIVTKDLAQCVEISNQYGPEHLIIQTRNA--RELVDSITSAGSVFLGDWSPE 356
            AL A   ++    + + +  +N++  EHL++   +     ++ ++ +AG++F+G  S  
Sbjct: 308 AALGARGGVVHMTSMDEAITFANRWAAEHLLLLVDDTQRDRVLAALRNAGTIFVGASSSV 367

Query: 357 SAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERL 416
           + GDY +G NHVLPT G   + S L   DF +  T QE++    ++L++ +   A AE L
Sbjct: 368 AFGDYMTGANHVLPTAGAARSYSGLSTLDFVRWTTWQEVTPAAAASLSADVGRFADAEGL 427

Query: 417 TAHKNAVTLR 426
            AH       
Sbjct: 428 PAHAATARTW 437


>UniRef50_C9SQK1 Histidine biosynthesis trifunctional protein n=1 Tax=Verticillium
           albo-atrum VaMs.102 RepID=C9SQK1_VERA1
          Length = 699

 Score =  412 bits (1061), Expect = e-113,   Method: Composition-based stats.
 Identities = 160/434 (36%), Positives = 223/434 (51%), Gaps = 79/434 (18%)

Query: 7   IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTAL 66
            D +  +A +  ++L RP+  + E+I   V  I+D V++ GD+A+  Y+ KF+K T    
Sbjct: 338 YDASKVSAAEVTEVLKRPSQKSPEAILNIVKPIIDEVRSGGDKAVLSYTHKFEKATSLTS 397

Query: 67  KVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKL-PPVDVETQPGVRCQQVTRPVA 125
            V        + +LS E  +A+ ++ +NI  FH AQK   P+ VET PGV C +++RP+ 
Sbjct: 398 PVLRAPFPEEAMKLSKESIKAIDISFENIRKFHAAQKEDKPLHVETMPGVVCSRMSRPIE 457

Query: 126 SVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIA----DEILYAAQLCGVQDV 181
            VGLYIPGG+A L ST LML  PA +AGCKK+V  SPP        EI+Y A   G + +
Sbjct: 458 RVGLYIPGGTAVLPSTALMLGVPAMVAGCKKIVFASPPRADGSLTPEIVYVAHKVGAESI 517

Query: 182 FNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLD-GAAIDMPAGPSEVL 240
              GGAQA+AALA+GTESVPKVDKI GPGN FVT AK  VS   + G +IDMPAGPSEV 
Sbjct: 518 VLAGGAQAVAALAYGTESVPKVDKILGPGNQFVTAAKMFVSNDTNAGVSIDMPAGPSEVR 577

Query: 241 VIADS-GATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETAR 299
            I ++   + D+    L+ Q ++ P                               E A+
Sbjct: 578 DIDEAMRISNDYAPEHLILQLKNAP-------------------------------EVAQ 606

Query: 300 QALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAG 359
             +NA  +                                         F+G+W+PES G
Sbjct: 607 MVMNAGSI-----------------------------------------FIGEWTPESVG 625

Query: 360 DYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAH 419
           DY++G NH LPTYG+    S + L  F K +T   L+ EG   + S +  LA  E L AH
Sbjct: 626 DYSAGVNHSLPTYGFAKQYSGVNLGSFVKHITSSNLTAEGLRNVGSAVMQLAKVEELEAH 685

Query: 420 KNAVTLRVNALKEQ 433
           + AV +R+N L ++
Sbjct: 686 RRAVEIRLNYLDKK 699


>UniRef50_B5YLM0 Histidinol dehydrogenase n=1 Tax=Thalassiosira pseudonana CCMP1335
           RepID=B5YLM0_THAPS
          Length = 441

 Score =  404 bits (1040), Expect = e-111,   Method: Composition-based stats.
 Identities = 140/397 (35%), Positives = 204/397 (51%), Gaps = 22/397 (5%)

Query: 49  EALREYSAKFDKTTV--TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPP 106
           +AL   + +        ++  VS+ +   A + LSDE ++++      ++ F  AQ+   
Sbjct: 48  KALISIARRLSDILPASSSYTVSSAQCKEAFDSLSDEDRRSLLNIHARVKLFADAQRGSV 107

Query: 107 VDVE-TQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPI 165
           VDVE   PG +      P  + G Y PGG  PL S+VLM    A  AGC  VVL SP P 
Sbjct: 108 VDVEVDIPGGKAGHTVSPCRAAGCYAPGGRYPLPSSVLMTVVTARSAGCPYVVLASPRP- 166

Query: 166 ADEILYAAQLCGVQDVFNVGGAQAIAALAFGTE------------SVPKVDKIFGPGNAF 213
           A   L AA + G   V  VGGAQAI  +A+G +            ++P  D I GPGN +
Sbjct: 167 APITLAAAHVAGADVVLCVGGAQAIGCMAYGVDEYDGEDGGTKVDAIPACDVIVGPGNKW 226

Query: 214 VTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTP 273
           VT AK  V+       IDM AGPSEVLVI D  A  + VA+DL++QAEH   ++ IL++ 
Sbjct: 227 VTAAKSIVNGH---CGIDMLAGPSEVLVICDHTANAEIVAADLIAQAEHDVVARAILVSD 283

Query: 274 AADMARRVAEAVERQLAELP--RAETARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQ 331
              +  +V + VE+Q+  LP     TA++AL  S  I+ KD+ +C+ +S++  PEHL IQ
Sbjct: 284 DKTVIDKVDQEVEKQVECLPEPNRSTAKEALKQSFSILCKDIDECIAMSDKLAPEHLEIQ 343

Query: 332 TRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMT 391
           T N++ +    ++ G +F+G  + E  GDY +G NH LPT G       L + +F +  T
Sbjct: 344 TLNSQSVGMKCSNYGGLFIGTHAAEVLGDYGAGPNHTLPTGGTGRYTGGLSVFNFLRIRT 403

Query: 392 VQELSKEG-FSALASTIETLAAAERLTAHKNAVTLRV 427
              + +EG    +      +A  E L  H  A   R 
Sbjct: 404 WMRIDEEGKSQEMVEDSVRMARLEGLEGHARAAEKRR 440


>UniRef50_UPI0001C3165E histidinol dehydrogenase n=1 Tax=Conexibacter woesei DSM 14684
           RepID=UPI0001C3165E
          Length = 426

 Score =  388 bits (997), Expect = e-106,   Method: Composition-based stats.
 Identities = 145/414 (35%), Positives = 206/414 (49%), Gaps = 18/414 (4%)

Query: 22  MRPAISASESITRTVNDILDNVKARGDEALREYSAKFD--KTTVTALKVSAEEIAAASER 79
           +R  + A+ SI   V  I+ +V+ RGD A+ E +   D       AL+VS  E+ AA + 
Sbjct: 21  LRRLVPAAASIADPVAAIVADVRDRGDAAVLELTRAHDTGGAEPKALRVSQSELDAALDS 80

Query: 80  LSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLF 139
           L  +++  + VA +N+            +V    G   +    PV    +Y+PGG AP  
Sbjct: 81  LDADVRAGLEVAAQNVGVVAAIGLDDEREVTLGHGQTVRLREVPVRRAAVYVPGGRAPYP 140

Query: 140 STVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQDVFNVGGAQAIAALAF 195
           STVLM    A  AG ++VVLCSPP     +   IL AA L G  +V+ +GGAQAI ALA 
Sbjct: 141 STVLMGVVTAVTAGVEEVVLCSPPGPDGDLNPAILAAAALAGATEVYRMGGAQAIGALAH 200

Query: 196 GTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASD 255
           GT +V  VD I GPGN +V EAKRQVS       ID  AGPS+++V+ D GA     A D
Sbjct: 201 GTATVAPVDLIVGPGNLWVQEAKRQVSA-AGLVGIDGFAGPSDLMVVLDRGADVRLAALD 259

Query: 256 LLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQ 315
           L +QAEHG DS V+ ++P           +   L+ +P             L+ T  L  
Sbjct: 260 LRAQAEHGSDSLVLAVSPDGAALDA----LSEGLSVVPEPGV-------GALVETASLED 308

Query: 316 CVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYT 375
            + ++N + PEHL +    A  L   + +AG +F+G     + GDY +G+NH LPT G  
Sbjct: 309 ALALANAFAPEHLELIGAGAEALAPEVRNAGCLFVGPGGATAFGDYVAGSNHTLPTDGAA 368

Query: 376 ATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNA 429
              S L    F++RMT   +  E  + LA     +A AE    H  ++  R+  
Sbjct: 369 RFASGLSARHFRRRMTEVRIPLEAATTLAPAGAAIARAEGFELHAQSMEARMRE 422


>UniRef50_C6UN35 Histidinal/histidinol dehydrogenase n=1 Tax=Candidatus Hodgkinia
           cicadicola Dsem RepID=C6UN35_HODCD
          Length = 428

 Score =  380 bits (977), Expect = e-104,   Method: Composition-based stats.
 Identities = 138/426 (32%), Positives = 203/426 (47%), Gaps = 11/426 (2%)

Query: 7   IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTAL 66
           +  +S    +  + ++      S  +      I   V A  D+AL  Y+ + D      L
Sbjct: 5   LRSDSPGFGEFVKGVIASRARVSARVKAVAEKISQTVSAYADKALMAYNLRLDGCASRLL 64

Query: 67  KVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVAS 126
           + +  +I    E +  +   ++ +A+  +   H+ Q      V    G +      PV+S
Sbjct: 65  RFAP-DID--LETVDVKALFSLKLALDRVAALHSLQLPSSCCVRDALGAKLGFRWTPVSS 121

Query: 127 VGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPI---ADEILYAAQLCGVQDVFN 183
           VG+Y+PGG+A   S+V+M   PA IAG   + L +P          +  A+LCGV  V+ 
Sbjct: 122 VGVYVPGGTASYLSSVIMCCVPARIAGVGHISLATPYSKLANKPLFMACAKLCGVACVYP 181

Query: 184 VGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIA 243
            GGA A+AAL+ GT +V KVDKI GPGNAFV  AK     R+    +D  AGPSE +++A
Sbjct: 182 FGGAHAVAALSVGTRAVRKVDKIVGPGNAFVAAAKALAQGRV---GVDCLAGPSEAVIVA 238

Query: 244 DSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALN 303
           D  A    +A D L Q EH  D+   ++  +A++A RV   V   +    R  TA ++ +
Sbjct: 239 DGVADAWTLAVDSLCQLEHASDALTAVVVSSAELASRVRANVALLVRSARRRRTAERSWS 298

Query: 304 ASRL-IVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYA 362
           A  + +V   +A      N    EH+        +L+  +TSAG+VFLG  SP   GDY 
Sbjct: 299 AGGVSVVCCCVADAAATVNALASEHVQACVLKPAKLLTKLTSAGAVFLGGGSPIVVGDYV 358

Query: 363 SGTNHVLPTYGYTATCSSLGLADFQKRMTVQEL-SKEGFSALASTIETLAAAERLTAHKN 421
            GTNH LPT       S L + DF KR  V  L +     ALA      A+AE L+ H  
Sbjct: 359 GGTNHTLPTASGAKFASGLSVLDFMKRTYVTWLPTARPMLALAPACAACASAEGLSCHAL 418

Query: 422 AVTLRV 427
           A   R+
Sbjct: 419 ASASRL 424


>UniRef50_A8M914 Histidinol dehydrogenase n=1 Tax=Caldivirga maquilingensis IC-167
           RepID=A8M914_CALMQ
          Length = 399

 Score =  378 bits (971), Expect = e-103,   Method: Composition-based stats.
 Identities = 131/414 (31%), Positives = 209/414 (50%), Gaps = 31/414 (7%)

Query: 21  LMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERL 80
           L+R A    + +   V  I+++VK  GDEAL   +++ D   ++++++S  E+ A +  +
Sbjct: 11  LLRKATDMDQYV-DRVRGIINDVKEHGDEALLRLTSELDGVKLSSIELSQSELRALASGI 69

Query: 81  SDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFS 140
              +++A+   + ++E+F+T  K    +   + G+R      P++ VGLY+P G    FS
Sbjct: 70  EPRVREALDEVMASVESFNTGVKPRDFEDYHR-GLRRGVKWVPLSRVGLYVPKG---YFS 125

Query: 141 TVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQDVFNVGGAQAIAALAFG 196
           T++M    A +AG ++++  +PP     I  EI Y A       VF VGGAQA+AALAFG
Sbjct: 126 TLVMTGVLAKVAGVEEIIAVTPPRRDGLIDPEIAYVALRLNA-RVFRVGGAQAVAALAFG 184

Query: 197 TESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDL 256
           TESVP+VDKI GPGNA+V  AK  VS  +    ID   GP+E++  AD G  P  VA DL
Sbjct: 185 TESVPRVDKIIGPGNAYVQAAKLLVSSHV---GIDGVEGPTELVTCADPGIKPITVALDL 241

Query: 257 LSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQC 316
            +Q EH   +  +++T +      + + + + L   P               +  + ++C
Sbjct: 242 AAQLEHA-GAVGVVVTWSEGYLTAIEDELSK-LTNAP-----------YFSTLVNEPSEC 288

Query: 317 VEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTA 376
           V + N+  PEH  I     +  ++ I +AG+V +   +P +  DYA+G +HVLPT G   
Sbjct: 289 VNVINEVAPEHASIW--GVKIPIEGIRNAGAVSI--MAPSALVDYAAGPSHVLPTGGSAR 344

Query: 377 TCSSLGLADFQKRMTVQE-LSKEGFSALASTIETLAAAERLTAHKNAVTLRVNA 429
               L   DF K +   E  S +    L      L   E    H  A+T  +N 
Sbjct: 345 WRGVLTPMDFMKPIAYVEPTSGDEARRLGELGAVLGLREGFRRHSEALTNWINE 398


>UniRef50_B7FPZ7 Histidinol dehydrogenase (Fragment) n=3 Tax=Eukaryota
           RepID=B7FPZ7_PHATR
          Length = 347

 Score =  377 bits (968), Expect = e-103,   Method: Composition-based stats.
 Identities = 134/338 (39%), Positives = 182/338 (53%), Gaps = 10/338 (2%)

Query: 95  IETFHTAQKLPPVDVE-TQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAG 153
           +  F T Q+   VD E   PG +  Q  RP  + G Y PGG  PL S+V+M A  A  AG
Sbjct: 1   VLAFATMQRSSVVDKEMDIPGGKAGQTVRPCGAAGCYAPGGRYPLPSSVIMTAVTARAAG 60

Query: 154 CKKVVLCSPPPIADEILYAAQLCGVQDVFNVGGAQAIAALAFGT--ESVPKVDKIFGPGN 211
           C+ VVL SP   A   L AA L G      VGGAQAIA++A+G     VP+ D I GPGN
Sbjct: 61  CETVVLSSP-KPAPITLAAAYLSGADHFLCVGGAQAIASMAYGIVDSDVPRCDVICGPGN 119

Query: 212 AFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILL 271
            +VT AK  V+       IDM AGPSEVLVI D  A P+ VA+DL++QAEH   ++ ILL
Sbjct: 120 KWVTAAKSIVNGH---CGIDMLAGPSEVLVICDDTANPEIVAADLIAQAEHDVVARAILL 176

Query: 272 TPAADMARRVAEAVERQLAELP--RAETARQALNASRLIVTKDLAQCVEISNQYGPEHLI 329
           + +  +  +V E V +Q+  LP     TA +AL  S  +  + L QC+ IS+   PEHL 
Sbjct: 177 STSDAIIEQVDENVSKQIEALPEPNRSTALEALKQSFAVKCESLEQCIAISDDIAPEHLE 236

Query: 330 IQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKR 389
           IQTR+A ++ ++  + G +F+G+ + E  GDY +G NH LPT G       L + +F + 
Sbjct: 237 IQTRDAMKVGEACNNYGGLFIGEHAAEVLGDYGAGPNHTLPTGGTGRYTGGLSVFNFLRV 296

Query: 390 MTVQELS-KEGFSALASTIETLAAAERLTAHKNAVTLR 426
            T   +        + +    +A  E L  H  A   R
Sbjct: 297 RTWMRVDNAAASQTMVNDSIIMARLEGLEGHARAAETR 334


>UniRef50_A8A9G5 Histidinol dehydrogenase n=1 Tax=Ignicoccus hospitalis KIN4/I
           RepID=A8A9G5_IGNH4
          Length = 404

 Score =  341 bits (876), Expect = 3e-92,   Method: Composition-based stats.
 Identities = 126/410 (30%), Positives = 195/410 (47%), Gaps = 34/410 (8%)

Query: 23  RPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSD 82
           R ++   E + + V  ++  VKARG EA+++Y+  FD      + +S E+ A+ S+   +
Sbjct: 26  RGSLDLWEYVEK-VMPVVKEVKARGLEAVKKYNKAFDNYE-GCVSLSQEDFASYSK---E 80

Query: 83  ELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTV 142
            L       ++ +  FH           +  GVR   + RPV  +G Y+PGG  P  ST 
Sbjct: 81  SLVSLFEEVLEQLSAFHKQTAPKD-SAFSSKGVRAVTLWRPVERLGAYVPGGLYPYPSTA 139

Query: 143 LMLATPASIAGCKKVVLCSPPPIA-DEILYAAQLC-GVQDVFNVGGAQAIAALAFGTESV 200
           LM A  A   G K+V + +PP  A  E++ +A L   V  V   GGA  ++ALA+    V
Sbjct: 140 LMTAGVAKALGVKEVTVATPPKFATSEVMASAFLASKVDSVLAAGGAHGVSALAY----V 195

Query: 201 PKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQA 260
               K+ GPG  +V  AK  VS  +    IDM AGP+E+ VIADS A P+ VA D+L+QA
Sbjct: 196 AGAHKVVGPGGPYVQAAKLLVSVDVP---IDMIAGPTELAVIADSSADPEEVAYDMLAQA 252

Query: 261 EHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQCVEIS 320
           EHGP S  +L++    +   V + V+             +        V +DL +   + 
Sbjct: 253 EHGPTSFALLVSTDEGLVLEVEKRVK-----------GEEVEGGLYATVVRDLEEAKRLV 301

Query: 321 NQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSS 380
           ++  PEH+ +        V     AG+      +P    DY++G NHVLPT G+      
Sbjct: 302 SELAPEHVSVYAETYEPPV-----AGAASF--KAPSPFLDYSAGPNHVLPTSGWAKARGP 354

Query: 381 LGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNAL 430
           LG  DF +  T+ E+  E  + L      LA  E +  H  A+  +++ +
Sbjct: 355 LGPVDFMRWTTLVEVFPEA-ADLLKLAAELARLEGMKYHAKAIEYKLSKI 403


>UniRef50_B9NIZ3 Histidinol dehydrogenase n=1 Tax=Populus trichocarpa
           RepID=B9NIZ3_POPTR
          Length = 394

 Score =  327 bits (838), Expect = 8e-88,   Method: Composition-based stats.
 Identities = 112/275 (40%), Positives = 157/275 (57%), Gaps = 12/275 (4%)

Query: 7   IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVT-- 64
           +       E      +  +     +I + V DIL +V+ RGD A+ EY+A+FD   V   
Sbjct: 114 LSTADANFEHDFAQRLHWSADTDAAIEQRVADILADVQKRGDAAVLEYTARFDGLQVEGM 173

Query: 65  -ALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKL---PPVDVETQPGVRCQQV 120
            AL+++  E+ AA + L DE + A+  A + + T+H AQK             G    Q 
Sbjct: 174 AALELTQAELKAAFDSLGDEQRDALTAAAQRVRTYHEAQKRASGESWSYRDADGTLLGQK 233

Query: 121 TRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCG 177
             P+  VG+Y+PGG A   S+VLM A PA +AG +++++  P P       +L AA + G
Sbjct: 234 VTPLDRVGIYVPGGKAAYPSSVLMNAIPAHVAGVQEIIMVVPTPRGEKNALVLAAAYVAG 293

Query: 178 VQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPS 237
           V   F +GGAQA+AALA+GT ++PKVDKI GPGNA+V  AK++V   +    IDM AGPS
Sbjct: 294 VTRGFTIGGAQAVAALAYGTATIPKVDKITGPGNAYVASAKKRVFGTV---GIDMIAGPS 350

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPDSQVILLT 272
           E+LV+AD    PD+VA DL SQAEH   +Q ILL 
Sbjct: 351 EILVLADGSTPPDWVAMDLFSQAEHDELAQSILLC 385


>UniRef50_P72946 Putative histidinol dehydrogenase 2 n=1 Tax=Synechocystis sp. PCC
           6803 RepID=HISX2_SYNY3
          Length = 409

 Score =  319 bits (818), Expect = 1e-85,   Method: Composition-based stats.
 Identities = 100/394 (25%), Positives = 167/394 (42%), Gaps = 20/394 (5%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              +I  +    ++ R+L  RP  S    + + V             A  E+ A  D   
Sbjct: 1   MLRLITQSGDIVQELRRLHHRPVPSPWPVMAQVV-------------AAMEHWAAMD--Q 45

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
               +VS  E+ AA +R+S E    +  A   +E  +  Q         + G    Q   
Sbjct: 46  DAPPRVSGAELDAAYQRISQEKLSVIRQACAALEQVYRPQLPKTQVSFPEDGTVRGQRFY 105

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVF 182
           PV   G Y+          +L     A   G  + VL +   I+  IL AAQ  G+++++
Sbjct: 106 PVRRAGFYLEAKRGDALGNLLRQGMLAKTVGVAERVLVTE-TISSTILVAAQEMGIEEIY 164

Query: 183 NVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVI 242
              G  AIA L +G +++  V+ I G G   V  AK+ VS  +    ID     + ++V+
Sbjct: 165 LAAGVPAIAMLTWGAKNIAPVESITGAGCPRVMAAKQLVSGVV---TIDQTLARTNLMVL 221

Query: 243 ADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL 302
           AD  A   ++A DLL+ AE  P++  +LLT   ++   V ++V R   E   +    +AL
Sbjct: 222 ADGEANGQWLALDLLAHAEQYPNASAVLLTDRLELGEEVIQSVNRYCREQEHSVHTEKAL 281

Query: 303 NASRLI-VTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDY 361
               L+ + +DL  C    N++ P  L++   +   +V+ +  A  +++G  SP   G Y
Sbjct: 282 AHYGLVAIVEDLEACGSWINEFCPHILLLAMEDPWTMVEKVQRAREIYIGHRSPSILGHY 341

Query: 362 ASGTNHVLPTYGYTATCSSLGLADFQKRMTVQEL 395
            SG N +    G  AT S L    F +   + + 
Sbjct: 342 LSGANRLQTQDGAMATASELAFHCFLRSSQLLDY 375


>UniRef50_Q8ZY17 Histidinol dehydrogenase n=5 Tax=Thermoproteaceae RepID=HISX_PYRAE
          Length = 368

 Score =  298 bits (764), Expect = 3e-79,   Method: Composition-based stats.
 Identities = 109/400 (27%), Positives = 180/400 (45%), Gaps = 34/400 (8%)

Query: 26  ISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELK 85
                 +  +V  I+D+V++ G +A  EYS + D        V+  +          E+ 
Sbjct: 2   RGFPREVLESVWKIVDDVQSGGLKAALEYSKRLDGVAPEPHLVTPRQ------GGDPEVV 55

Query: 86  QAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLML 145
            A   A K++E  ++    PP  V+   G+  Q + +PV    LY+P   A   ST++ML
Sbjct: 56  SAALAAAKSLEALYSR-ISPPAAVDFYGGILRQILWKPVRRAALYVP---ARYISTLVML 111

Query: 146 ATPASIAGCKKVVLCSPP-PIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVD 204
           A PA +AG ++V + +PP  +++E+L  A+  GV+ V  +GG   +A   F       VD
Sbjct: 112 AVPARLAGVEEVYVVTPPRGVSEELLAVAKELGVKAVLALGGPHGLAYAVFHM----GVD 167

Query: 205 KIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGP 264
            + GPG  +V  AK  +SQ +    ID   GP+E+++ A  G  P+      L+Q EHGP
Sbjct: 168 VVAGPGGLYVQAAKYILSQYV---GIDGIEGPTELVIYA-EGVPPEVAVRGALAQLEHGP 223

Query: 265 DSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQCVEISNQYG 324
            S   LL+P  ++ ++  E   R+            ++   ++     + + V   ++  
Sbjct: 224 TSFAYLLSPDGELLKKAEELYVRERT---------SSMGPLKVKKVGGIDEAVSFIDEIA 274

Query: 325 PEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLA 384
           PEHL +  R  RE+   + + G+V +    P    DY +G +HVLPT G       +   
Sbjct: 275 PEHLEVWGR--REVAYRVRNVGAVSVNM--PSPYLDYVAGISHVLPTGGTARWRGVITPL 330

Query: 385 DFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVT 424
            F K + + E   E    L      LA  E    H  A+ 
Sbjct: 331 AFMKPIGIAEAVGE--LTLREAARKLAEYEGFKYHGEALR 368


>UniRef50_B8NVQ6 Histidinol dehydrogenase, putative n=1 Tax=Aspergillus flavus
           NRRL3357 RepID=B8NVQ6_ASPFN
          Length = 224

 Score =  224 bits (572), Expect = 5e-57,   Method: Composition-based stats.
 Identities = 78/247 (31%), Positives = 113/247 (45%), Gaps = 39/247 (15%)

Query: 187 AQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSG 246
             A+AA+A GTE++ KVD + G GN FV E KRQ+   +    ID+ AGP+EVLV+AD  
Sbjct: 11  VPAVAAIAVGTETIRKVDFLAGTGNRFVAEGKRQLFGEV---GIDLFAGPTEVLVLADET 67

Query: 247 ATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLA--ELPRAETARQALNA 304
           A P  VA DL+SQA HGPD+  +L+T    + R   E V + L+  +L   + A+ + +A
Sbjct: 68  ADPFTVAMDLISQAGHGPDTPAVLITTCPKVGRETIEIVNKLLSATDLSTPDVAKVSWDA 127

Query: 305 -SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYAS 363
              +I+   L +  E+ + Y  E + +                                 
Sbjct: 128 FGEVIIVDTLEELWELGDHYASEQVQVI-------------------------------- 155

Query: 364 GTNHVLPTYGYTATCSSLGLADFQKRMTVQELS-KEGFSALASTIETLAAAERLTAHKNA 422
           GTNH+LPT         L +  + K  T QE++  E    L       A  ER  A   +
Sbjct: 156 GTNHILPTRTTARYTGGLWVGKYLKTCTYQEVTLPESSGKLGRLCGRAARPERFEAPARS 215

Query: 423 VTLRVNA 429
             LR N 
Sbjct: 216 GDLRANR 222


>UniRef50_UPI0001909A69 histidinol dehydrogenase n=1 Tax=Rhizobium etli IE4771
           RepID=UPI0001909A69
          Length = 287

 Score =  211 bits (539), Expect = 3e-53,   Method: Composition-based stats.
 Identities = 65/178 (36%), Positives = 94/178 (52%), Gaps = 6/178 (3%)

Query: 20  LLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA---LKVSAEEIAAA 76
           L +      SE +      I+D+VKARGD AL    A   +   +    ++V+ EEI AA
Sbjct: 31  LFLTTKREVSEDVNAVARAIIDDVKARGDVALCRIFADIRRHRFSPPVPMRVTPEEIDAA 90

Query: 77  SERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSA 136
            E +  E+  A+ +A   IE+ H  Q       E   GVR       + +VGLY+PGG+A
Sbjct: 91  VEAVPSEVLGALKLAALRIESHHRRQLPKDDIYEDDLGVRLGSRWTAIEAVGLYVPGGTA 150

Query: 137 PLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCGVQDVFNVGGAQAIA 191
              S+VLM A PA +AG  ++V+  P     +   +L AA+L GV +++ VGGAQAIA
Sbjct: 151 SYPSSVLMNAVPAKVAGVDRIVIAVPATGGAVNPAVLAAARLAGVTEIYRVGGAQAIA 208


>UniRef50_C5GHZ5 Histidinol dehydrogenase n=2 Tax=Ajellomyces dermatitidis
           RepID=C5GHZ5_AJEDR
          Length = 281

 Score =  209 bits (532), Expect = 2e-52,   Method: Composition-based stats.
 Identities = 72/270 (26%), Positives = 116/270 (42%), Gaps = 63/270 (23%)

Query: 65  ALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPV 124
           + K+S  +I AA  ++S++  + +  A  N                         +   V
Sbjct: 2   SFKLSEGDIEAAVVKVSEQTIKDIKEAQAN-----------------------GYIW--V 36

Query: 125 ASVGLYIPGGSAPLFSTVLMLATP---ASIAGCKKVVLCSPP---PIADEILYAAQLCGV 178
             + L +  G   L S+          + +AG   V +C+PP    I +       L G 
Sbjct: 37  RRIFLLVQLGRRFLPSSFHTQEVQFCNSKVAGVNHVTMCTPPINGKIPNATTATTHLVGA 96

Query: 179 QDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSE 238
            ++F +GGAQAIA +A GTES+ KVD I   G                   +D+ AGP+E
Sbjct: 97  NEIFILGGAQAIAGMAVGTESIRKVDSIAEIG-------------------VDLFAGPTE 137

Query: 239 VLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETA 298
           V             A+ LLSQAEHGPDS  +L+T + D A++V   ++R L  L  A  A
Sbjct: 138 V------------PATHLLSQAEHGPDSPAVLITTSEDSAKQVMTLIDRFLETLSTAAIA 185

Query: 299 RQALNASR-LIVTKDLAQCVEISNQYGPEH 327
             A  + R +++   + +   + ++Y  +H
Sbjct: 186 STAWRSFREVVIVDSIDEAYALGDEYAFDH 215


>UniRef50_C7H2J0 Histidinol dehydrogenase n=1 Tax=Faecalibacterium prausnitzii
           A2-165 RepID=C7H2J0_9FIRM
          Length = 162

 Score =  205 bits (523), Expect = 2e-51,   Method: Composition-based stats.
 Identities = 51/164 (31%), Positives = 84/164 (51%), Gaps = 4/164 (2%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              + +++    E+     +   I A +++   V+ I+  V+ARGDEAL+EY+ KFD   
Sbjct: 1   MIKLYNFDELRPEEI----LNRDIRAEKNVEDVVDGIIAEVRARGDEALKEYALKFDGAK 56

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
           +  L+V+  EI  A   +     + +  A  NIE+FH  Q      +  +PG+   Q   
Sbjct: 57  IDDLQVTQAEIDEAFANMDPYFLETLREAAANIESFHRQQVHKNFVINEKPGIVLGQKYT 116

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIA 166
           P+   G+Y+PGG+A   STVLM   PA +AG  ++V+ +P    
Sbjct: 117 PIEKAGVYVPGGTAAYPSTVLMDVIPAKVAGVSEIVMTTPAGKD 160


>UniRef50_A3J633 Histidinol dehydrogenase (Fragment) n=1 Tax=Flavobacteria bacterium
           BAL38 RepID=A3J633_9FLAO
          Length = 136

 Score =  159 bits (403), Expect = 2e-37,   Method: Composition-based stats.
 Identities = 57/140 (40%), Positives = 83/140 (59%), Gaps = 4/140 (2%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              I +      E   ++  RP  + S  +  TV  I   V+ +G++A+ +Y++ FD  T
Sbjct: 1   MKKIYN---PQPETWLEICKRPTQTFS-DVEETVKQIFKKVQQKGNKAIAKYTSFFDGVT 56

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
           +  ++V+ EEI  A + ++ ELK+A+ +A  NIE FH AQK   + VET  GV C Q  R
Sbjct: 57  LENIQVTPEEIELAKKEVATELKKAIQLAKSNIEQFHAAQKTDKIVVETTIGVTCWQEKR 116

Query: 123 PVASVGLYIPGGSAPLFSTV 142
           P+  VGLYIPGG+APLFSTV
Sbjct: 117 PIQKVGLYIPGGTAPLFSTV 136


>UniRef50_B4CYY3 NAD+ oxidoreductase n=1 Tax=Chthoniobacter flavus Ellin428
           RepID=B4CYY3_9BACT
          Length = 162

 Score =  133 bits (336), Expect = 1e-29,   Method: Composition-based stats.
 Identities = 40/147 (27%), Positives = 68/147 (46%), Gaps = 9/147 (6%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
              +  NS   +     L R A +    + +TV D+L+ ++  GD AL E++ +F    +
Sbjct: 1   MRTLRHNSPGFKSSLNSLKRSAEA-HPQVRKTVQDVLEAIRTEGDSALLEFTERFGGPRL 59

Query: 64  --TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVT 121
               L+V+ +       ++  E K+A+A A  N+  F          ++   G    +  
Sbjct: 60  TAKQLRVTGK------PKVDAETKEAVATAHANVLAFARKSLRENWTMKNAQGGLVGERF 113

Query: 122 RPVASVGLYIPGGSAPLFSTVLMLATP 148
            P   VG+Y+PGG+APL ST +M  TP
Sbjct: 114 DPFKRVGIYVPGGTAPLVSTAVMTVTP 140


>UniRef50_UPI0001696B01 histidinol dehydrogenase n=2 Tax=Listeria monocytogenes
           RepID=UPI0001696B01
          Length = 123

 Score =  120 bits (302), Expect = 1e-25,   Method: Composition-based stats.
 Identities = 38/114 (33%), Positives = 61/114 (53%)

Query: 15  EQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIA 74
           E   +L +    + S  +   V  I++ VK  GD+AL ++++KFD   +T L+V A +I 
Sbjct: 10  ELLNELKIETDTNTSIQVETEVKTIIEKVKTAGDQALFDFTSKFDGVGLTELRVPAADIQ 69

Query: 75  AASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVG 128
           AAS ++      A+  A  NIE+FH+ QK        + GV   Q+ RP+ +VG
Sbjct: 70  AASAKIEPAFLDALQQAKVNIESFHSKQKQHAFLDSEKDGVIRGQLIRPLETVG 123


>UniRef50_D1ND55 Histidinol dehydrogenase (Fragment) n=1 Tax=Haemophilus influenzae
           HK1212 RepID=D1ND55_HAEIN
          Length = 104

 Score =  111 bits (278), Expect = 6e-23,   Method: Composition-based stats.
 Identities = 43/105 (40%), Positives = 61/105 (58%), Gaps = 1/105 (0%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
             TII WN  +  ++R+++MRP     ++I + VN I +NV   GD AL E   KFD   
Sbjct: 1   MQTII-WNHLSETEKRKVIMRPVQQNGKNIQQAVNAIRENVAYNGDRALFELCEKFDGVK 59

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPV 107
           +  L VS +EI AAS R+S +L+ A+  A  NIE FH AQ+   +
Sbjct: 60  LDKLIVSVDEIQAASSRISVKLRNAIEQAKTNIEAFHKAQQNQEI 104


>UniRef50_D1KBK9 Histidinol dehydrogenase n=1 Tax=uncultured SUP05 cluster bacterium
           RepID=D1KBK9_9GAMM
          Length = 146

 Score = 95.9 bits (238), Expect = 3e-18,   Method: Composition-based stats.
 Identities = 27/122 (22%), Positives = 52/122 (42%), Gaps = 4/122 (3%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
               +       +++   L+     +S  I +TV+DI+ N++  GD+AL +Y+ KFD   
Sbjct: 1   MIARLSTQQADFQEKLSKLLAWESVSSTDIAQTVDDIIANIRQNGDQALIDYTNKFDGMD 60

Query: 63  VTA---LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQP-GVRCQ 118
           V+    L V    +  A + L+++ K A+  A   +  +    K   +   T+  G    
Sbjct: 61  VSDISALTVDQSALKKAFDSLAEKEKTALQSAADRVRDYPPKNKSKTLGTYTEDNGTLLG 120

Query: 119 QV 120
             
Sbjct: 121 SK 122


>UniRef50_C7ZHH7 Putative uncharacterized protein n=1 Tax=Nectria haematococca mpVI
           77-13-4 RepID=C7ZHH7_NECH7
          Length = 337

 Score = 81.3 bits (200), Expect = 7e-14,   Method: Composition-based stats.
 Identities = 19/70 (27%), Positives = 26/70 (37%), Gaps = 1/70 (1%)

Query: 362 ASGTNHVLPTYGYTATCSSLGLADFQKRMTVQE-LSKEGFSALASTIETLAAAERLTAHK 420
             G+NHVLPT         L +  F K  T QE + +     +       + AE    H 
Sbjct: 54  CIGSNHVLPTRKVGNYTGGLWVGKFLKTQTYQEIVDERASGEMGRLCGRCSRAENFEVHA 113

Query: 421 NAVTLRVNAL 430
            +  LRV   
Sbjct: 114 RSGDLRVKKY 123


>UniRef50_UPI00016988E7 histidinol dehydrogenase n=1 Tax=Endoriftia persephone
          'Hot96_1+Hot96_2' RepID=UPI00016988E7
          Length = 102

 Score = 66.3 bits (161), Expect = 2e-09,   Method: Composition-based stats.
 Identities = 18/82 (21%), Positives = 39/82 (47%), Gaps = 3/82 (3%)

Query: 1  MSFNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDK 60
          MS    +  +    + +   L+     +  ++  TVN+I+  +++RGD AL E++++FD 
Sbjct: 1  MSEIRQLSSSDADFQSRLDALLAWESVSDRAVNDTVNNIIAEIRSRGDAALVEFTSRFDG 60

Query: 61 TTVTA---LKVSAEEIAAASER 79
              +   L++    +  A E 
Sbjct: 61 WQAASAADLELPLSRLEQAWEH 82


>UniRef50_C0S8B7 Histidinol dehydrogenase n=1 Tax=Paracoccidioides brasiliensis Pb03
           RepID=C0S8B7_PARBP
          Length = 227

 Score = 62.8 bits (152), Expect = 2e-08,   Method: Composition-based stats.
 Identities = 27/103 (26%), Positives = 41/103 (39%), Gaps = 32/103 (31%)

Query: 239 VLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETA 298
           VL++A + A    +A+DLLSQAEH PDS  ++ T A D  +            L      
Sbjct: 128 VLIVAGNKADRFTIATDLLSQAEHSPDSPAVIFTTAEDAGK------------LETRY-- 173

Query: 299 RQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDS 341
                               ++++Y  EH+ I T+  RE    
Sbjct: 174 ------------------FRLADEYAFEHVQILTQPPREAGAR 198



 Score = 44.3 bits (104), Expect = 0.009,   Method: Composition-based stats.
 Identities = 13/43 (30%), Positives = 25/43 (58%), Gaps = 1/43 (2%)

Query: 37 NDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASER 79
            +++++++ GD A+R +S KFD    T  K S ++I A   +
Sbjct: 34 KRVIEDIRSNGDSAVR-HSTKFDHWEPTPFKPSDDDIQAVIAK 75


>UniRef50_D2MHU6 Putative uncharacterized protein (Fragment) n=1 Tax=Candidatus
          Poribacteria sp. WGA-A3 RepID=D2MHU6_9BACT
          Length = 74

 Score = 57.8 bits (139), Expect = 7e-07,   Method: Composition-based stats.
 Identities = 19/72 (26%), Positives = 29/72 (40%), Gaps = 2/72 (2%)

Query: 3  FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
             +I     T  +    +   A      I   V  IL NV+  GD A+  Y  KFD  T
Sbjct: 1  MMNVISSKDKTYPEALAEVCNRAACQHAKIEGRVKRILKNVERNGDAAVSRYVKKFDGLT 60

Query: 63 VTA--LKVSAEE 72
          ++    +VS++ 
Sbjct: 61 LSPKKFRVSSKR 72


>UniRef50_C8S5L7 Putative uncharacterized protein n=1 Tax=Rhodobacter sp. SW2
           RepID=C8S5L7_9RHOB
          Length = 151

 Score = 54.0 bits (129), Expect = 1e-05,   Method: Composition-based stats.
 Identities = 22/73 (30%), Positives = 36/73 (49%), Gaps = 3/73 (4%)

Query: 252 VASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELP---RAETARQALNASRLI 308
             +DL+ QAEHG +S V L+T    +A RV   V   +  LP   RA  A    + + +I
Sbjct: 16  ATADLVGQAEHGYNSPVWLVTSDRGLAARVTALVPELIVALPEPNRASAAAAWADLAEVI 75

Query: 309 VTKDLAQCVEISN 321
           + +D  +   + +
Sbjct: 76  LCEDAEEMARVFD 88


>UniRef50_B8FPV4 Putative cell wall binding repeat 2-containing protein n=2
           Tax=Desulfitobacterium hafniense RepID=B8FPV4_DESHD
          Length = 530

 Score = 40.9 bits (95), Expect = 0.096,   Method: Composition-based stats.
 Identities = 29/136 (21%), Positives = 55/136 (40%), Gaps = 26/136 (19%)

Query: 157 VVLCSPPPIADEILYAAQLCGVQDVFNVGGAQAIAA------LAFGTESVPKVDKIFGPG 210
           +++ S   +++E+L+     G + V+ +GG  AI+A        FG  +     ++ G  
Sbjct: 275 ILMTSSQRLSNEVLHEILNLGAETVYMIGGTGAISAEIESELQTFGITT----QRLAGA- 329

Query: 211 NAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVIL 270
           N + T A+           I    GPS+ + +A     PD +A    + A+       IL
Sbjct: 330 NRYDTAAQ-----------IAELVGPSDRVYLAYGYGEPDAIAVSSFAAAQ----GASIL 374

Query: 271 LTPAADMARRVAEAVE 286
           LT    +       ++
Sbjct: 375 LTDTHSLPEETQNRLK 390


Searching..................................................done


Results from round 2


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value
Sequences used in model and found again:

UniRef50_Q5E638 Histidinol dehydrogenase n=29 Tax=Bacteria RepID...   612   e-174
UniRef50_P62456 Histidinol dehydrogenase n=127 Tax=Bacteria RepI...   586   e-166
UniRef50_Q4QN74 Histidinol dehydrogenase n=38 Tax=cellular organ...   585   e-166
UniRef50_Q8R882 Histidinol dehydrogenase n=7 Tax=Clostridia RepI...   584   e-165
UniRef50_D1PYE8 Histidinol dehydrogenase n=2 Tax=Prevotella RepI...   583   e-165
UniRef50_Q492K3 Histidinol dehydrogenase n=542 Tax=Proteobacteri...   582   e-165
UniRef50_O26327 Histidinol dehydrogenase n=6 Tax=Euryarchaeota R...   580   e-164
UniRef50_UPI00019859BD PREDICTED: hypothetical protein n=1 Tax=V...   580   e-164
UniRef50_Q39YP7 Histidinol dehydrogenase n=54 Tax=Bacteria RepID...   579   e-164
UniRef50_Q58851 Histidinol dehydrogenase n=16 Tax=Euryarchaeota ...   579   e-164
UniRef50_D1IQ57 Histidinol dehydrogenase (Fragment) n=1 Tax=Viti...   578   e-163
UniRef50_Q465R4 Histidinol dehydrogenase n=7 Tax=Euryarchaeota R...   578   e-163
UniRef50_P59398 Histidinol dehydrogenase n=5 Tax=Buchnera aphidi...   577   e-163
UniRef50_Q722Y3 Histidinol dehydrogenase n=20 Tax=Firmicutes Rep...   575   e-162
UniRef50_A8RCE7 Putative uncharacterized protein n=1 Tax=Eubacte...   574   e-162
UniRef50_Q02136 Histidinol dehydrogenase n=9 Tax=Bacteria RepID=...   571   e-161
UniRef50_Q9C5U8 Histidinol dehydrogenase, chloroplastic n=34 Tax...   570   e-161
UniRef50_Q30TA4 Histidinol dehydrogenase n=16 Tax=Epsilonproteob...   570   e-161
UniRef50_Q6FEC8 Histidinol dehydrogenase n=50 Tax=Bacteria RepID...   568   e-161
UniRef50_Q8YSM8 Histidinol dehydrogenase 1 n=16 Tax=Bacteria Rep...   568   e-160
UniRef50_D1CF70 Histidinol dehydrogenase n=1 Tax=Thermobaculum t...   568   e-160
UniRef50_Q4ZNV9 Histidinol dehydrogenase n=116 Tax=Bacteria RepI...   565   e-159
UniRef50_C0GFZ9 Histidinol dehydrogenase n=1 Tax=Dethiobacter al...   564   e-159
UniRef50_Q46J19 Histidinol dehydrogenase n=60 Tax=Bacteria RepID...   563   e-159
UniRef50_P59399 Histidinol dehydrogenase n=14 Tax=Bacteria RepID...   561   e-158
UniRef50_C6Y3G2 Histidinol dehydrogenase n=6 Tax=cellular organi...   561   e-158
UniRef50_B9D1F9 Histidinol dehydrogenase n=2 Tax=Campylobacter R...   560   e-158
UniRef50_B0TY46 Histidinol dehydrogenase n=2 Tax=Francisella phi...   559   e-158
UniRef50_D0RRH1 Histidinol dehydrogenase n=1 Tax=alpha proteobac...   557   e-157
UniRef50_A9NV24 Histidinol dehydrogenase n=2 Tax=Spermatophyta R...   557   e-157
UniRef50_D0JBA3 Histidinol dehydrogenase n=2 Tax=Blattabacterium...   554   e-156
UniRef50_C9LTV1 Histidinol dehydrogenase n=1 Tax=Selenomonas spu...   553   e-156
UniRef50_C9KKX1 Histidinol dehydrogenase n=1 Tax=Mitsuokella mul...   553   e-156
UniRef50_P00815 Histidinol dehydrogenase n=17 Tax=cellular organ...   552   e-156
UniRef50_Q2NHT1 HisD n=1 Tax=Methanosphaera stadtmanae DSM 3091 ...   552   e-155
UniRef50_Q5FS83 Histidinol dehydrogenase n=3 Tax=Bacteria RepID=...   551   e-155
UniRef50_Q1Q2D0 Histidinol dehydrogenase n=1 Tax=Candidatus Kuen...   550   e-155
UniRef50_C0QG33 Histidinol dehydrogenase n=4 Tax=Deltaproteobact...   550   e-155
UniRef50_B2KCM4 Histidinol dehydrogenase n=1 Tax=Elusimicrobium ...   547   e-154
UniRef50_Q2PPB3 Histidine biosynthesis trifunctional protein n=1...   547   e-154
UniRef50_B3WED5 Histidinol dehydrogenase n=21 Tax=Bacilli RepID=...   544   e-153
UniRef50_C4V2I6 Histidinol dehydrogenase n=1 Tax=Selenomonas flu...   544   e-153
UniRef50_D2RJQ0 Histidinol dehydrogenase n=7 Tax=Firmicutes RepI...   543   e-153
UniRef50_C1PFR7 Histidinol dehydrogenase n=1 Tax=Bacillus coagul...   543   e-153
UniRef50_B2A652 Histidinol dehydrogenase n=1 Tax=Natranaerobius ...   543   e-153
UniRef50_C3XDE7 Histidinol dehydrogenase n=1 Tax=Helicobacter bi...   542   e-153
UniRef50_Q46WL2 Histidinol dehydrogenase 1 n=202 Tax=Bacteria Re...   541   e-152
UniRef50_Q3J079 Histidinol dehydrogenase 1 n=26 Tax=Proteobacter...   540   e-152
UniRef50_B3TCH3 Putative Histidinol dehydrogenase n=1 Tax=uncult...   540   e-152
UniRef50_Q3AR25 Histidinol dehydrogenase n=13 Tax=Bacteria RepID...   540   e-152
UniRef50_C7LV94 Histidinol dehydrogenase n=6 Tax=Desulfovibriona...   538   e-151
UniRef50_Q4FQF8 Histidinol dehydrogenase n=6 Tax=Proteobacteria ...   538   e-151
UniRef50_P62457 Histidinol dehydrogenase n=27 Tax=cellular organ...   538   e-151
UniRef50_Q186D5 Histidinol dehydrogenase n=9 Tax=Bacteria RepID=...   537   e-151
UniRef50_Q313T7 Histidinol dehydrogenase n=7 Tax=Deltaproteobact...   536   e-151
UniRef50_D1YWF4 Histidinol dehydrogenase n=1 Tax=Methanocella pa...   532   e-149
UniRef50_A9A0A6 Histidinol dehydrogenase n=2 Tax=Desulfobacterac...   530   e-149
UniRef50_Q5ZW87 Histidinol dehydrogenase n=6 Tax=Legionella RepI...   530   e-149
UniRef50_Q9X0D1 Histidinol dehydrogenase n=6 Tax=Thermotogaceae ...   530   e-149
UniRef50_B9KYT3 Histidinol dehydrogenase n=1 Tax=Thermomicrobium...   526   e-148
UniRef50_Q3B5E3 Histidinol dehydrogenase n=8 Tax=Chlorobiaceae R...   523   e-147
UniRef50_Q87C29 Histidinol dehydrogenase n=66 Tax=cellular organ...   519   e-146
UniRef50_Q3ZXL7 Histidinol dehydrogenase n=5 Tax=Dehalococcoides...   519   e-146
UniRef50_Q9P777 Histidinol dehydrogenase n=71 Tax=cellular organ...   519   e-145
UniRef50_B3DXR9 Histidinol dehydrogenase n=1 Tax=Methylacidiphil...   516   e-145
UniRef50_Q4P7D9 Putative uncharacterized protein n=3 Tax=Eukaryo...   516   e-145
UniRef50_A3EUM9 Histidinol dehydrogenase n=3 Tax=Leptospirillum ...   515   e-144
UniRef50_C7NG13 Histidinol dehydrogenase n=2 Tax=Bacteria RepID=...   513   e-144
UniRef50_A5D1M4 Histidinol dehydrogenase n=1 Tax=Pelotomaculum t...   513   e-144
UniRef50_C8WUX6 Histidinol dehydrogenase n=2 Tax=Alicyclobacillu...   512   e-144
UniRef50_P62460 Histidinol dehydrogenase n=15 Tax=Bacteria RepID...   511   e-143
UniRef50_Q4FNE2 Histidinol dehydrogenase 1 n=3 Tax=Candidatus Pe...   507   e-142
UniRef50_D0LM64 Histidinol dehydrogenase n=2 Tax=Nannocystineae ...   506   e-142
UniRef50_Q4A044 Histidinol dehydrogenase n=62 Tax=Staphylococcus...   506   e-142
UniRef50_C9RN89 Histidinol dehydrogenase n=1 Tax=Fibrobacter suc...   506   e-142
UniRef50_Q01ZU1 Histidinol dehydrogenase n=1 Tax=Candidatus Soli...   503   e-141
UniRef50_B1YL14 Histidinol dehydrogenase n=1 Tax=Exiguobacterium...   501   e-140
UniRef50_UPI00016BFCCC histidinol dehydrogenase n=1 Tax=Epulopis...   498   e-139
UniRef50_Q5WIU9 Histidinol dehydrogenase 1 n=52 Tax=cellular org...   496   e-139
UniRef50_C4L171 Histidinol dehydrogenase n=1 Tax=Exiguobacterium...   496   e-139
UniRef50_Q67KH6 Histidinol dehydrogenase n=1 Tax=Symbiobacterium...   495   e-138
UniRef50_B1H0F0 Histidinol dehydrogenase n=1 Tax=uncultured Term...   493   e-138
UniRef50_Q7UX39 Histidinol dehydrogenase n=6 Tax=Planctomycetace...   490   e-137
UniRef50_B3T638 Histidinol dehydrogenase n=1 Tax=uncultured mari...   490   e-137
UniRef50_Q8TXG3 Histidinol dehydrogenase n=1 Tax=Methanopyrus ka...   490   e-137
UniRef50_UPI00017455E1 Histidinol dehydrogenase n=1 Tax=Verrucom...   489   e-137
UniRef50_A6UA68 Histidinol dehydrogenase n=4 Tax=Proteobacteria ...   489   e-137
UniRef50_D1N997 Histidinol dehydrogenase n=2 Tax=Lentisphaerae R...   489   e-137
UniRef50_A1ZJE8 Histidinol dehydrogenase n=1 Tax=Microscilla mar...   488   e-136
UniRef50_Q483H8 Histidinol dehydrogenase 2 n=15 Tax=Proteobacter...   487   e-136
UniRef50_Q13I58 Histidinol dehydrogenase n=22 Tax=cellular organ...   486   e-136
UniRef50_C0G418 Histidinol dehydrogenase n=2 Tax=Rhizobiales Rep...   486   e-136
UniRef50_P73058 Histidinol dehydrogenase 1 n=11 Tax=Cyanobacteri...   481   e-134
UniRef50_Q4JW59 Histidinol dehydrogenase n=104 Tax=Actinobacteri...   480   e-134
UniRef50_D0XPF3 Histidinol dehydrogenase n=1 Tax=Brevundimonas s...   480   e-134
UniRef50_A4QA32 Histidinol dehydrogenase n=16 Tax=cellular organ...   478   e-133
UniRef50_Q64EP7 Histidinol dehydrogenase n=2 Tax=environmental s...   476   e-133
UniRef50_B4W8G9 Histidinol dehydrogenase n=2 Tax=Caulobacteracea...   476   e-132
UniRef50_A9A5X6 Histidinol dehydrogenase n=2 Tax=Thaumarchaeota ...   475   e-132
UniRef50_A3Q131 Histidinol dehydrogenase n=6 Tax=Mycobacterium R...   475   e-132
UniRef50_B2UMH6 Histidinol dehydrogenase n=3 Tax=Verrucomicrobia...   475   e-132
UniRef50_Q1AX10 Histidinol dehydrogenase n=1 Tax=Rubrobacter xyl...   475   e-132
UniRef50_D2RSH8 Histidinol dehydrogenase n=1 Tax=Haloterrigena t...   474   e-132
UniRef50_B0S9F2 Histidinol dehydrogenase n=6 Tax=Leptospira RepI...   473   e-132
UniRef50_D1B7M0 Histidinol dehydrogenase n=2 Tax=Bacteria RepID=...   472   e-131
UniRef50_C1FAE2 Histidinol dehydrogenase n=1 Tax=Acidobacterium ...   470   e-131
UniRef50_Q2HFX2 Putative uncharacterized protein n=1 Tax=Chaetom...   467   e-130
UniRef50_B6A0U7 Histidinol dehydrogenase n=1 Tax=Rhizobium legum...   466   e-130
UniRef50_D2R570 Histidinol dehydrogenase n=1 Tax=Pirellula stale...   466   e-130
UniRef50_Q82AA6 Histidinol dehydrogenase n=29 Tax=Actinobacterid...   466   e-130
UniRef50_Q5JFR5 Histidinol dehydrogenase n=9 Tax=cellular organi...   466   e-129
UniRef50_Q3IQR5 Histidinol dehydrogenase n=10 Tax=Halobacteriace...   464   e-129
UniRef50_Q5YYQ0 Histidinol dehydrogenase n=8 Tax=Actinomycetales...   461   e-128
UniRef50_C0GVA3 Histidinol dehydrogenase n=1 Tax=Desulfonatronos...   461   e-128
UniRef50_B8E2C3 Histidinol dehydrogenase n=1 Tax=Dictyoglomus tu...   459   e-128
UniRef50_Q1D4L9 Histidinol dehydrogenase n=2 Tax=Cystobacterinea...   458   e-127
UniRef50_B5YE85 Histidinol dehydrogenase n=1 Tax=Dictyoglomus th...   458   e-127
UniRef50_Q1IKB6 Histidinol dehydrogenase n=1 Tax=Candidatus Kori...   454   e-126
UniRef50_O33775 Histidinol dehydrogenase n=12 Tax=Sulfolobaceae ...   454   e-126
UniRef50_Q46N53 Histidinol dehydrogenase 2 n=50 Tax=root RepID=H...   450   e-125
UniRef50_A9G5W4 HisD protein n=1 Tax=Sorangium cellulosum 'So ce...   446   e-123
UniRef50_C7LZ86 Histidinol dehydrogenase n=1 Tax=Acidimicrobium ...   444   e-123
UniRef50_Q0AP81 Histidinol dehydrogenase, Histidinol-phosphatase...   438   e-121
UniRef50_A0R401 Histidinol dehydrogenase n=2 Tax=Actinomycetales...   436   e-120
UniRef50_C7RAI8 Histidinol dehydrogenase n=1 Tax=Kangiella koree...   436   e-120
UniRef50_B1ZNB2 Histidinol dehydrogenase n=3 Tax=Verrucomicrobia...   429   e-119
UniRef50_C1A4M1 Histidinol dehydrogenase n=1 Tax=Gemmatimonas au...   422   e-116
UniRef50_C9SQK1 Histidine biosynthesis trifunctional protein n=1...   420   e-116
UniRef50_B5YLM0 Histidinol dehydrogenase n=1 Tax=Thalassiosira p...   408   e-112
UniRef50_UPI0001C3165E histidinol dehydrogenase n=1 Tax=Conexiba...   390   e-107
UniRef50_C6UN35 Histidinal/histidinol dehydrogenase n=1 Tax=Cand...   388   e-106
UniRef50_A8M914 Histidinol dehydrogenase n=1 Tax=Caldivirga maqu...   382   e-104
UniRef50_B7FPZ7 Histidinol dehydrogenase (Fragment) n=3 Tax=Euka...   379   e-104
UniRef50_A8A9G5 Histidinol dehydrogenase n=1 Tax=Ignicoccus hosp...   344   4e-93
UniRef50_B9NIZ3 Histidinol dehydrogenase n=1 Tax=Populus trichoc...   332   2e-89
UniRef50_P72946 Putative histidinol dehydrogenase 2 n=1 Tax=Syne...   327   4e-88
UniRef50_Q8ZY17 Histidinol dehydrogenase n=5 Tax=Thermoproteacea...   298   2e-79
UniRef50_B8NVQ6 Histidinol dehydrogenase, putative n=1 Tax=Asper...   226   2e-57
UniRef50_UPI0001909A69 histidinol dehydrogenase n=1 Tax=Rhizobiu...   211   3e-53
UniRef50_C5GHZ5 Histidinol dehydrogenase n=2 Tax=Ajellomyces der...   211   6e-53
UniRef50_C7H2J0 Histidinol dehydrogenase n=1 Tax=Faecalibacteriu...   207   7e-52
UniRef50_A3J633 Histidinol dehydrogenase (Fragment) n=1 Tax=Flav...   158   4e-37
UniRef50_B4CYY3 NAD+ oxidoreductase n=1 Tax=Chthoniobacter flavu...   142   2e-32
UniRef50_UPI0001696B01 histidinol dehydrogenase n=2 Tax=Listeria...   123   1e-26
UniRef50_D1ND55 Histidinol dehydrogenase (Fragment) n=1 Tax=Haem...   109   2e-22
UniRef50_D1KBK9 Histidinol dehydrogenase n=1 Tax=uncultured SUP0...   102   4e-20
UniRef50_C7ZHH7 Putative uncharacterized protein n=1 Tax=Nectria...    82   3e-14
UniRef50_UPI00016988E7 histidinol dehydrogenase n=1 Tax=Endorift...    73   2e-11
UniRef50_D2MHU6 Putative uncharacterized protein (Fragment) n=1 ...    65   4e-09
UniRef50_C0S8B7 Histidinol dehydrogenase n=1 Tax=Paracoccidioide...    63   2e-08
UniRef50_C8S5L7 Putative uncharacterized protein n=1 Tax=Rhodoba...    55   5e-06

Sequences not found previously or not previously below threshold:

UniRef50_B8FPV4 Putative cell wall binding repeat 2-containing p...    42   0.058


CONVERGED!
>UniRef50_Q5E638 Histidinol dehydrogenase n=29 Tax=Bacteria RepID=HISX_VIBF1
          Length = 439

 Score =  612 bits (1579), Expect = e-174,   Method: Composition-based stats.
 Identities = 275/429 (64%), Positives = 328/429 (76%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
              + W S +  QQ  +L RPAI+   +IT  V  +++ VK  GD  +   + KFD    
Sbjct: 1   MKTLVWQSLSDSQQDTVLQRPAITEGANITAAVTSVINTVKQEGDAGVFALTEKFDGVKP 60

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRP 123
            +++VS  EI AAS+RLS+E+K A+  A  NI  FH AQK  PV VETQPGV C+Q+T P
Sbjct: 61  DSIRVSNAEIEAASDRLSEEMKTALKQAYSNISKFHQAQKPQPVKVETQPGVICEQITMP 120

Query: 124 VASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVFN 183
           +  VGLYIPGGSAPL STVLML  PA IAGC KVVLCSPPPIADEILY A+LC + +V+N
Sbjct: 121 INKVGLYIPGGSAPLPSTVLMLGIPAQIAGCHKVVLCSPPPIADEILYVAKLCKIDEVYN 180

Query: 184 VGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIA 243
           +GGAQA+AA+A+GTESV KVDKIFGPGNA+VTEAKRQVS    GAAIDMPAGPSEVLVIA
Sbjct: 181 IGGAQAVAAMAYGTESVSKVDKIFGPGNAYVTEAKRQVSNDFRGAAIDMPAGPSEVLVIA 240

Query: 244 DSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALN 303
           D  A PDF+A+DLLSQAEHGPDSQV+L+TP+  +A +VA+AVERQL EL R + ARQAL 
Sbjct: 241 DESADPDFIAADLLSQAEHGPDSQVVLVTPSPIIADQVADAVERQLKELSREDIARQALG 300

Query: 304 ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYAS 363
           +S LIV   L QCV ISN YGPEHLI+QT+N REL+  + +AGS+FLGD+SPESAGDYAS
Sbjct: 301 SSLLIVADSLTQCVSISNFYGPEHLIVQTKNPRELLPLLDNAGSIFLGDYSPESAGDYAS 360

Query: 364 GTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAV 423
           GTNHVLPTYGYT T SSLGLADF KRMTVQEL+ +G   LA T+ T+A AE L AHK AV
Sbjct: 361 GTNHVLPTYGYTRTYSSLGLADFSKRMTVQELTADGLKGLAPTVVTMAEAEGLDAHKRAV 420

Query: 424 TLRVNALKE 432
           T+R+  L +
Sbjct: 421 TIRIEKLAQ 429


>UniRef50_P62456 Histidinol dehydrogenase n=127 Tax=Bacteria RepID=HISX_BACC1
          Length = 429

 Score =  586 bits (1512), Expect = e-166,   Method: Composition-based stats.
 Identities = 169/419 (40%), Positives = 251/419 (59%), Gaps = 7/419 (1%)

Query: 17  QRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAA 76
           + +LL   A    E++ R V++I+ NV+  GDEAL  Y+ KFD   +   +VS EE   A
Sbjct: 14  KIKLLRENANIIEETVQRNVSEIVRNVRESGDEALSFYTKKFDGVKIKEFRVSEEEEKRA 73

Query: 77  SERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSA 136
           S  + +   +A+  A KNI ++H  QK   +      G+   Q+ RP+ +VG+Y+PGG+A
Sbjct: 74  SMFVENSFLEALQEAKKNIISYHEKQKRQSMFDCASEGIIRGQIIRPLENVGVYVPGGTA 133

Query: 137 PLFSTVLMLATPASIAGCKKVVLCSPP---PIADEILYAAQLCGVQDVFNVGGAQAIAAL 193
              S+VLM   PA +AG KK+V+ +PP    I   IL AA L GV +++ +GGAQAIAAL
Sbjct: 134 SYPSSVLMNVLPAKLAGVKKIVMVTPPREGGIDPHILVAASLAGVDEIYTIGGAQAIAAL 193

Query: 194 AFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVA 253
           A+GTES+PKVDKI GPGN +V  AKR+V   ++   IDM AGPSE++VIAD      ++A
Sbjct: 194 AYGTESIPKVDKIVGPGNLYVALAKREVYGIVN---IDMIAGPSEIVVIADETGNAKYIA 250

Query: 254 SDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALN-ASRLIVTKD 312
           +DLLSQAEH   +  I +T   ++A++V + +ERQL  LPR+E AR+++N    + +   
Sbjct: 251 ADLLSQAEHDERATAICITTNIELAKKVEKEIERQLETLPRSEIARESINRNGAIFIVPS 310

Query: 313 LAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTY 372
           + + +++SN+  PEHL +  +     +  +  AGS+FLG ++PE  GDY +G NHVLPT 
Sbjct: 311 IDEALQLSNEIAPEHLELHIKEPMNALAYVKHAGSIFLGPYAPEPLGDYLAGPNHVLPTS 370

Query: 373 GYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNALK 431
           G     S L + DF K+ +    ++E    +   I  LA  E L AH  A+ +R    +
Sbjct: 371 GTARFFSPLSVDDFVKKSSFLSYTEEALRDVQHHIVELANKEGLHAHARAIQIRFEEEE 429


>UniRef50_Q4QN74 Histidinol dehydrogenase n=38 Tax=cellular organisms
           RepID=HISX_HAEI8
          Length = 427

 Score =  585 bits (1510), Expect = e-166,   Method: Composition-based stats.
 Identities = 272/428 (63%), Positives = 328/428 (76%), Gaps = 2/428 (0%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
              I WN  +  ++R+++MRP     E+I + VN I +NV   GD AL E   KFD   +
Sbjct: 1   MQTIIWNHLSETEKRKVIMRPVQQNGENIQQAVNAIRENVAYNGDRALFELCEKFDGVKL 60

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRP 123
             L VSA+EI AAS R+S +L+ A+  A  NIE FH AQ+   +D+E Q GVRCQ VTRP
Sbjct: 61  DKLIVSADEIQAASSRISVKLRNAIEQAKTNIEAFHKAQQNQEIDLEIQEGVRCQVVTRP 120

Query: 124 VASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVFN 183
           ++ VGLYIPGGSAPLFSTVLMLA PA IAGCKK+VLCSPPPI+DEILY A LCGV+ ++ 
Sbjct: 121 ISCVGLYIPGGSAPLFSTVLMLAIPAKIAGCKKIVLCSPPPISDEILYTAHLCGVETIYA 180

Query: 184 VGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIA 243
           +GGAQA+ A+A GTESV KVDKIFGPGNAFVTEAKRQV+Q  +  AIDMPAGPSEVLVIA
Sbjct: 181 IGGAQAVFAMAQGTESVAKVDKIFGPGNAFVTEAKRQVAQ--NSTAIDMPAGPSEVLVIA 238

Query: 244 DSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALN 303
           D  A P+FVASDLLSQAEHG DSQVIL+     +A+  A A+ERQLA LPRAETAR+ALN
Sbjct: 239 DESADPEFVASDLLSQAEHGADSQVILVATCETLAKETALAIERQLALLPRAETARKALN 298

Query: 304 ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYAS 363
            SR+ + + L Q VEISN+Y PEHLI+QT+NAR+L+  + +AGS+FLG +SPES GDYAS
Sbjct: 299 HSRIFIAESLEQAVEISNEYAPEHLIVQTKNARKLLPYLDNAGSIFLGAYSPESMGDYAS 358

Query: 364 GTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAV 423
           GTNHVLPTYGYT T SSLGLADF KRMTVQEL+ +GF  LA T+E +A AE+L AHK AV
Sbjct: 359 GTNHVLPTYGYTKTYSSLGLADFSKRMTVQELTPKGFKNLAETVEVMAEAEQLAAHKMAV 418

Query: 424 TLRVNALK 431
           ++R+  L 
Sbjct: 419 SVRLAKLN 426


>UniRef50_Q8R882 Histidinol dehydrogenase n=7 Tax=Clostridia RepID=HISX_THETN
          Length = 430

 Score =  584 bits (1506), Expect = e-165,   Method: Composition-based stats.
 Identities = 180/431 (41%), Positives = 266/431 (61%), Gaps = 10/431 (2%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              + D+           +   +   ++ I + V DI++NV+ R D+AL EY+  +D   
Sbjct: 1   MIEMFDFTKEVDIGIFNKIQNRSKLENKEIAKRVEDIIENVRERKDKALFEYTYMYDGIN 60

Query: 63  VTA--LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQV 120
           + +  +KV  EEI  A E + ++  +A+  A+KNI  FH  QK     ++ + G+   QV
Sbjct: 61  LNSETVKVKEEEIKRAYEEVKEDFLKALDKAIKNITEFHEKQKEKTW-MDFKEGIVYGQV 119

Query: 121 TRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCG 177
            RP++SVG+Y+PGG+A   S+VLM   PA +AG +++V+ SP     I+  +L AA   G
Sbjct: 120 LRPLSSVGIYVPGGTASYPSSVLMNGIPAKVAGVERIVMVSPAGKKGISPYVLVAADKIG 179

Query: 178 VQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPS 237
           +++++ +GGAQA+AALAFGTES+PKVDKI GPGN +V  AKR +   +D   IDM AGPS
Sbjct: 180 IKEIYKIGGAQAVAALAFGTESIPKVDKIVGPGNIYVAMAKRALYGYVD---IDMVAGPS 236

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAET 297
           E+LVIAD  A+P +VA+DLLSQAEH   +  IL+T + ++A +V + +ERQ+  L R E 
Sbjct: 237 EILVIADESASPKYVAADLLSQAEHDVMASSILVTTSKELAEKVKKEIERQMEYLERKEI 296

Query: 298 ARQALNA-SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPE 356
             ++L     +IV  +L + + I+N+  PEHL +   N  E++  I +AG+VFLG++SPE
Sbjct: 297 IAESLKNFGAIIVIDNLKEAIGIANEIAPEHLELVIENPFEILGEIKNAGAVFLGEFSPE 356

Query: 357 SAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERL 416
             GDY +G NHVLPT G     S L + DF K+M V   SKE  S++   + TLA AE L
Sbjct: 357 PLGDYLAGPNHVLPTSGTARFFSPLSVRDFVKKMNVLYYSKEALSSVKDDVITLAEAEEL 416

Query: 417 TAHKNAVTLRV 427
           TAH N+V +R 
Sbjct: 417 TAHANSVKVRF 427


>UniRef50_D1PYE8 Histidinol dehydrogenase n=2 Tax=Prevotella RepID=D1PYE8_9BACT
          Length = 444

 Score =  583 bits (1504), Expect = e-165,   Method: Composition-based stats.
 Identities = 212/434 (48%), Positives = 286/434 (65%), Gaps = 9/434 (2%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
             II +      +  ++L RP +  S  +  TVN+IL +VK+RGDEA+R Y A FD+  +
Sbjct: 1   MHIIKY--PPKSEWSRILKRPHLDVS-QLNETVNEILSDVKSRGDEAVRHYEALFDQADL 57

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRP 123
             L VS EEI  A   +S +LK+A+ +A  NI  FH +Q      VET  GV C Q +  
Sbjct: 58  GDLTVSDEEIDEAMSMVSTDLKEALELAYHNISKFHESQLFHGKMVETAQGVVCWQKSVA 117

Query: 124 VASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQ 179
           +  VGLYIPGG+APLFSTVLMLATPA IAGCK +VLC+PP     I   IL AA + GV 
Sbjct: 118 IEKVGLYIPGGTAPLFSTVLMLATPAKIAGCKDIVLCTPPNHDGKIHPAILVAAHIAGVD 177

Query: 180 DVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEV 239
            +F  GG QAI A+A+GT+++PKV KIFGPGN +V  AK+QVS  L   AIDMPAGPSEV
Sbjct: 178 RIFKAGGVQAIGAMAYGTQTIPKVYKIFGPGNQYVMAAKQQVS--LHDVAIDMPAGPSEV 235

Query: 240 LVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETAR 299
            VIAD G+  +FVA+DLLSQAEHG DSQV+L++ + ++   V   VERQL  LPR E A 
Sbjct: 236 CVIADEGSNAEFVAADLLSQAEHGSDSQVMLISTSDNLITEVRSQVERQLENLPRREIAS 295

Query: 300 QALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAG 359
            AL  S+ ++  D+ + + +SN+Y PEHLI+ T N  E+ D + +AGSVF+G WS ESAG
Sbjct: 296 DALKNSKFVLVHDMDEAMRLSNEYAPEHLILSTGNFEEMADKVVNAGSVFMGKWSCESAG 355

Query: 360 DYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAH 419
           DYASGTNH LPT+ Y    S + L  + +++T Q+LS+ G S++ + +  +A  E L AH
Sbjct: 356 DYASGTNHTLPTHQYALAYSGVNLDSYCRKITFQQLSENGVSSIGNAVVRMAEDEGLEAH 415

Query: 420 KNAVTLRVNALKEQ 433
            +A+ +R+  + ++
Sbjct: 416 AHAMRIRLKKVDDK 429


>UniRef50_Q492K3 Histidinol dehydrogenase n=542 Tax=Proteobacteria RepID=HISX_BLOPB
          Length = 443

 Score =  582 bits (1501), Expect = e-165,   Method: Composition-based stats.
 Identities = 232/427 (54%), Positives = 305/427 (71%)

Query: 7   IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTAL 66
           I WN C+  +Q++LL RP  +    I   V +IL  V   GD AL +++  FD    T L
Sbjct: 10  IYWNDCSKSEQKKLLTRPINNKLNDIYINVKNILTKVYNEGDRALFKFNFDFDNVQTTQL 69

Query: 67  KVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVAS 126
           ++  E I  +   LS+E+KQA+  A+ NI  FH AQ    + VET PGV CQQ+ RP+  
Sbjct: 70  QIPTEIIMNSGRNLSNEIKQAIHTAMTNITRFHQAQCYSEIIVETLPGVYCQQIIRPLNI 129

Query: 127 VGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVFNVGG 186
           VGLY+PGG+APL STV+ML  PA IA CK+V+LCSPPPI D I+Y AQLCG+ +++ +GG
Sbjct: 130 VGLYVPGGTAPLLSTVMMLGVPARIAKCKRVILCSPPPIPDVIIYTAQLCGIDEIYQIGG 189

Query: 187 AQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSG 246
           +Q+IAA+ FGTES+PKVDKIFGPGN +VTEAKRQ++   +GAAIDM AGPSE+L+IAD+ 
Sbjct: 190 SQSIAAMGFGTESIPKVDKIFGPGNIWVTEAKRQINLAPNGAAIDMLAGPSEILIIADNT 249

Query: 247 ATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASR 306
           A P F+A+DLLSQ+EHGPDS  IL+TP + +A +  + + +QL  LPR +  R  L  SR
Sbjct: 250 ANPIFIAADLLSQSEHGPDSHAILITPYSCIAEKTKKELHKQLKILPRNDIVRNVLLNSR 309

Query: 307 LIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTN 366
           +I+T +L +C  ISN Y PEHLIIQ  NA + +  IT+AGS+FLG+WSPE+AGDYASG N
Sbjct: 310 MIITNNLMECFSISNSYAPEHLIIQIENASDYLHYITNAGSIFLGNWSPETAGDYASGPN 369

Query: 367 HVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
           HVLPTYG     S LG+ DFQKRM+VQ+L++ G   L+STI TL   E+L AH+ A+T R
Sbjct: 370 HVLPTYGRAVATSGLGVIDFQKRMSVQQLTQNGLLQLSSTITTLTQIEQLKAHEYAITHR 429

Query: 427 VNALKEQ 433
           +N +KEQ
Sbjct: 430 INYIKEQ 436


>UniRef50_O26327 Histidinol dehydrogenase n=6 Tax=Euryarchaeota RepID=HISX_METTH
          Length = 426

 Score =  580 bits (1495), Expect = e-164,   Method: Composition-based stats.
 Identities = 181/430 (42%), Positives = 256/430 (59%), Gaps = 9/430 (2%)

Query: 5   TIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVT 64
            ++        +  +L+ R  +     +   V DI+  V+  GD+ALRE + +FD  TV 
Sbjct: 1   MLMKITEFDYRRISELVERARLDVD-DVLGPVADIISMVRDGGDDALRELTGRFDGVTVE 59

Query: 65  ALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPV 124
             +VS EEI  A + L   +K+A+  A  NIE FH  Q       E +PGV   Q+ RP+
Sbjct: 60  NFRVSREEIEEAHKNLEPGVKEALREAASNIEEFHRMQMPSGWMSEVRPGVMAGQLVRPI 119

Query: 125 ASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQD 180
            SVG YIPGG A   ST+LM   PA IAG +++V C+PP     + D +L AA + G  +
Sbjct: 120 DSVGCYIPGGRAVYPSTILMTVIPARIAGVERIVCCTPPAQDGSVPDAVLVAADMAGASE 179

Query: 181 VFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVL 240
           ++ VGGAQA+AA+A+GTE++  VDKI GPGN FVT AK+ V   +D   ID PAGPSEVL
Sbjct: 180 IYRVGGAQAVAAMAYGTETIRPVDKIVGPGNIFVTAAKKLVYGEVD---IDFPAGPSEVL 236

Query: 241 VIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQ 300
           +IAD  A+P+++A ++L+QAEH P +  +L+T + D+A  V E V   +  + RA   R+
Sbjct: 237 IIADETASPEYIALEILAQAEHDPQAASVLVTDSRDLALEVKEMVHENIKYMERANIIRE 296

Query: 301 ALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAG 359
           +L     +++T D+ + V+ SN Y PEHL+I T +  E ++ I +AGS+FLG+ SP +AG
Sbjct: 297 SLERYGMIVLTADIDEAVDFSNAYAPEHLVIMTDSPEETLEGIRNAGSIFLGELSPVAAG 356

Query: 360 DYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAH 419
           DY SGTNHVLPT G     S L    F K+ TVQ ++KEG   L  T+  LA  E L AH
Sbjct: 357 DYGSGTNHVLPTSGCARMYSGLSTESFIKKPTVQRITKEGLRNLQGTVLKLAEYEGLHAH 416

Query: 420 KNAVTLRVNA 429
             +   R+  
Sbjct: 417 AESFRRRLRD 426


>UniRef50_UPI00019859BD PREDICTED: hypothetical protein n=1 Tax=Vitis vinifera
           RepID=UPI00019859BD
          Length = 524

 Score =  580 bits (1495), Expect = e-164,   Method: Composition-based stats.
 Identities = 207/435 (47%), Positives = 272/435 (62%), Gaps = 8/435 (1%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
                 +  +  +   L  RP I  S SI   V+ I+D+V++RGD A+++Y+ +FDK  +
Sbjct: 87  MKSYRLSELSQAEVNSLKARPRIDFS-SIFNVVHPIVDDVRSRGDAAVKDYTTRFDKVEL 145

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRP 123
             L  +  E+      L   +K+A  VA  NI  FH AQK     VE   GV+C++V R 
Sbjct: 146 DRLIENVAELPD--PELDAGIKEAFDVAYDNIFAFHAAQKSAEKIVENMKGVKCKRVARS 203

Query: 124 VASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQ 179
           +ASVGLY+PGG+A L ST LML+ PA IAGCK VVL +PP     I  E+LY A+  GV 
Sbjct: 204 IASVGLYVPGGTAVLPSTALMLSVPAQIAGCKTVVLATPPSQDGGICKEVLYCAKKAGVT 263

Query: 180 DVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEV 239
            +   GGAQAIAA+A+GT S PKV+KIFGPGN +VT AK  +       +IDMPAGPSEV
Sbjct: 264 HILKAGGAQAIAAMAWGTTSCPKVEKIFGPGNQYVTAAKMILQNSEAMVSIDMPAGPSEV 323

Query: 240 LVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADM-ARRVAEAVERQLAELPRAETA 298
           LVIAD  A P  +A+DLLSQAEHGPDSQV+L+     +  R + E + +Q   LPR E A
Sbjct: 324 LVIADKHANPVHIAADLLSQAEHGPDSQVVLVIAGDGVDLRAIEEEISKQCQSLPRGEFA 383

Query: 299 RQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESA 358
            +AL+ S  +  +++ + +  SN Y PEHLII  ++A +  + I +AGSVFLG W+PES 
Sbjct: 384 SKALSHSFTVFARNMVEAISFSNLYAPEHLIINVKDAEKWENFIENAGSVFLGQWTPESV 443

Query: 359 GDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTA 418
           GDYASGTNHVLPTYGY      L L  F K MTVQ L++EG   L   +E +A  E L A
Sbjct: 444 GDYASGTNHVLPTYGYARMYGGLSLDSFLKYMTVQSLTEEGLRKLGPYVEAMAEVEGLEA 503

Query: 419 HKNAVTLRVNALKEQ 433
           HK AVTLR+  ++ +
Sbjct: 504 HKRAVTLRLQDIEAR 518


>UniRef50_Q39YP7 Histidinol dehydrogenase n=54 Tax=Bacteria RepID=HISX_GEOMG
          Length = 436

 Score =  579 bits (1493), Expect = e-164,   Method: Composition-based stats.
 Identities = 172/437 (39%), Positives = 251/437 (57%), Gaps = 10/437 (2%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT- 62
              +D      + +   ++         + + V DI+ +V+ARGDEAL EY+ +FD+   
Sbjct: 1   MKFLDIRDTNFDMEFAAILARGEETGREVEQVVLDIIADVRARGDEALLEYTRRFDRLEA 60

Query: 63  --VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQV 120
             V +L+V+ +E+  A  R+ DE   A+ +AV+ +  FH  QK        +P +   Q+
Sbjct: 61  DSVASLQVTEDEVDYAFARVKDEEIAALKLAVERVARFHEKQKQETWLSTGEPDILLGQM 120

Query: 121 TRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCG 177
             P+  VG+Y+PGG A   S+V+M A PA +AG  +VV+ +P P   I   +L AA+  G
Sbjct: 121 VTPLERVGIYVPGGKASYPSSVIMNAVPARVAGVGEVVMVAPTPGGEINPHVLVAARFSG 180

Query: 178 VQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPS 237
           V  +F +GGAQA+AALA+GT +VPKVDKI GPGN +V  AK+ V  ++    IDM AGPS
Sbjct: 181 VDRIFRLGGAQAVAALAYGTATVPKVDKITGPGNIYVATAKKLVFGQV---GIDMIAGPS 237

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAET 297
           E+LVI D   TP  +A+DLLSQAEH   +  IL+T       RVA  VERQLAEL R   
Sbjct: 238 EILVINDGSGTPAHIAADLLSQAEHDELASSILITTDRGFGERVAAEVERQLAELSRETI 297

Query: 298 ARQALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPE 356
           AR++      +IV   L + +  SN+  PEHL +   N  +++  I +AG++FLG ++PE
Sbjct: 298 ARRSWETYGAVIVAGSLDEAIAFSNRIAPEHLELAVTNPFDVLPKIRNAGAIFLGHFTPE 357

Query: 357 SAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERL 416
           +AGDY +G NH LPT G     S L + DF K+ ++   S+ G + L   I  +A  E L
Sbjct: 358 AAGDYLAGPNHTLPTGGTARFFSPLSVDDFVKKSSIVYFSESGLNRLGGGIVRIAELEGL 417

Query: 417 TAHKNAVTLRVNALKEQ 433
            AH  +V++R+    E 
Sbjct: 418 EAHGRSVSVRLKGEGEA 434


>UniRef50_Q58851 Histidinol dehydrogenase n=16 Tax=Euryarchaeota RepID=HISX_METJA
          Length = 429

 Score =  579 bits (1493), Expect = e-164,   Method: Composition-based stats.
 Identities = 176/433 (40%), Positives = 250/433 (57%), Gaps = 9/433 (2%)

Query: 1   MSFNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDK 60
           M    II       +++ + ++    +  E I  TV +IL +VK +GDEAL+ Y+ KFD 
Sbjct: 1   MVTGMIIKKIKELTKEEEEKIINRNKANFEEILPTVMEILKDVKEKGDEALKYYTKKFDG 60

Query: 61  TTVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQP-GVRCQQ 119
             +   KV+ EEI  A   +  ++ +A+  A +NI  FH  Q     D+  +  G+   Q
Sbjct: 61  VEIEDFKVTDEEIEEAYNSVDYKVVEAIERAKENIYFFHKKQMEQIKDLNVENNGIILGQ 120

Query: 120 VTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPI----ADEILYAAQL 175
           V R +  VG Y+PGG A   STVLM   PA +AGC+++ + SPP          L A  +
Sbjct: 121 VVRAIEKVGCYVPGGRAFYPSTVLMTTIPAKVAGCEEIYITSPPTKDGKGNPATLIAGDI 180

Query: 176 CGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAG 235
            GV  ++ VGG QAI ALA+GTE++PKVD I GPGN +VT AK+ V   +   AID  AG
Sbjct: 181 VGVSAIYKVGGVQAIGALAYGTETIPKVDIIVGPGNIYVTTAKKMVYGEV---AIDFLAG 237

Query: 236 PSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRA 295
           PSEVL+IAD  A  +FVA D ++QAEH P++  ++ T +   A  +   +  ++ +  R 
Sbjct: 238 PSEVLIIADETANAEFVALDFIAQAEHDPNASCVITTTSEKKAEEIKNKIFEEIEKAERK 297

Query: 296 ETARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSP 355
           E   +AL  S +++  DL +C+E SN+Y PEHL I T+N  E+++ I  AGSVFLG++SP
Sbjct: 298 EIILKALENSAILI-GDLEECIEFSNKYAPEHLEILTKNPEEVLNKIKHAGSVFLGEYSP 356

Query: 356 ESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAER 415
              GDYASGTNHVLPT  +    S L +  F K++T Q+L KE    +A  + TLA AE 
Sbjct: 357 VPVGDYASGTNHVLPTSQFARMSSGLNVETFLKKITYQKLDKESLKNIADIVITLAEAEG 416

Query: 416 LTAHKNAVTLRVN 428
           L  H  AV  R+ 
Sbjct: 417 LFGHAEAVRRRLK 429


>UniRef50_D1IQ57 Histidinol dehydrogenase (Fragment) n=1 Tax=Vitis vinifera
           RepID=D1IQ57_VITVI
          Length = 546

 Score =  578 bits (1491), Expect = e-163,   Method: Composition-based stats.
 Identities = 207/435 (47%), Positives = 272/435 (62%), Gaps = 8/435 (1%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
                 +  +  +   L  RP I  S SI   V+ I+D+V++RGD A+++Y+ +FDK  +
Sbjct: 109 MKSYRLSELSQAEVNSLKARPRIDFS-SIFNVVHPIVDDVRSRGDAAVKDYTTRFDKVEL 167

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRP 123
             L  +  E+      L   +K+A  VA  NI  FH AQK     VE   GV+C++V R 
Sbjct: 168 DRLIENVAELPD--PELDAGIKEAFDVAYDNIFAFHAAQKSAEKIVENMKGVKCKRVARS 225

Query: 124 VASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQ 179
           +ASVGLY+PGG+A L ST LML+ PA IAGCK VVL +PP     I  E+LY A+  GV 
Sbjct: 226 IASVGLYVPGGTAVLPSTALMLSVPAQIAGCKTVVLATPPSQDGGICKEVLYCAKKAGVT 285

Query: 180 DVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEV 239
            +   GGAQAIAA+A+GT S PKV+KIFGPGN +VT AK  +       +IDMPAGPSEV
Sbjct: 286 HILKAGGAQAIAAMAWGTTSCPKVEKIFGPGNQYVTAAKMILQNSEAMVSIDMPAGPSEV 345

Query: 240 LVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADM-ARRVAEAVERQLAELPRAETA 298
           LVIAD  A P  +A+DLLSQAEHGPDSQV+L+     +  R + E + +Q   LPR E A
Sbjct: 346 LVIADKHANPVHIAADLLSQAEHGPDSQVVLVIAGDGVDLRAIEEEISKQCQSLPRGEFA 405

Query: 299 RQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESA 358
            +AL+ S  +  +++ + +  SN Y PEHLII  ++A +  + I +AGSVFLG W+PES 
Sbjct: 406 SKALSHSFTVFARNMVEAISFSNLYAPEHLIINVKDAEKWENFIENAGSVFLGQWTPESV 465

Query: 359 GDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTA 418
           GDYASGTNHVLPTYGY      L L  F K MTVQ L++EG   L   +E +A  E L A
Sbjct: 466 GDYASGTNHVLPTYGYARMYGGLSLDSFLKYMTVQSLTEEGLRKLGPYVEAMAEVEGLEA 525

Query: 419 HKNAVTLRVNALKEQ 433
           HK AVTLR+  ++ +
Sbjct: 526 HKRAVTLRLQDIEAR 540


>UniRef50_Q465R4 Histidinol dehydrogenase n=7 Tax=Euryarchaeota RepID=HISX_METBF
          Length = 433

 Score =  578 bits (1490), Expect = e-163,   Method: Composition-based stats.
 Identities = 182/432 (42%), Positives = 252/432 (58%), Gaps = 10/432 (2%)

Query: 1   MSFNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDK 60
           M        +  +  + ++LL R   S  E + +TV+ +L +V+ +GD ALREY+AKFDK
Sbjct: 1   MVMMLFKKLSDVSEAEMQKLLSRG--SGLEDVAKTVSTVLSDVRTKGDSALREYTAKFDK 58

Query: 61  TTVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLP-PVDVETQPGVRCQQ 119
             +    VS EE   A   +S EL   +  A  NI  FH AQ       +E +PG+   Q
Sbjct: 59  VELANFGVSEEEFQQALSGISPELLDHLKSAAANIRAFHEAQLPKATWFMELKPGIVLGQ 118

Query: 120 VTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQL 175
              P+ SVG Y PGG A   STVLM   PA +AG ++V++C+PP     +    L AA++
Sbjct: 119 KATPLESVGAYAPGGRASYPSTVLMTVIPARVAGVEQVIVCTPPRPDGSVHPLTLAAAKV 178

Query: 176 CGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAG 235
            G   VF +GG QAI ++A+GTE+VPKVDKI GPGN FVT AK Q+    D A ID PAG
Sbjct: 179 AGADKVFKLGGVQAIGSMAYGTETVPKVDKIVGPGNVFVTAAKMQIR---DVAEIDFPAG 235

Query: 236 PSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRA 295
           PSEVL+IAD  A    VASD+L+Q+EH P+S  IL+T +  +A  V   V  Q  +  R+
Sbjct: 236 PSEVLIIADESADAVMVASDILAQSEHDPNSVSILVTGSDTLAEAVKREVLVQAEQAARS 295

Query: 296 ETARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSP 355
              + +L  + +++   L QC+  SN++ PEHL I   +   ++D I +AGS+F+G++SP
Sbjct: 296 SIIKSSLENAAILIADSLEQCIGFSNKFAPEHLEIMVADPDFVLDRIKNAGSIFIGNYSP 355

Query: 356 ESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAER 415
              GDYASGTNHVLPT GY    S L +  F K  ++Q +SK G  +L  T+  LA  E 
Sbjct: 356 VPVGDYASGTNHVLPTSGYARVYSGLNINHFIKYSSIQRISKSGLESLKETVIALAEEEG 415

Query: 416 LTAHKNAVTLRV 427
           L AH +A+  R 
Sbjct: 416 LQAHADAIRTRF 427


>UniRef50_P59398 Histidinol dehydrogenase n=5 Tax=Buchnera aphidicola
           RepID=HISX_BUCBP
          Length = 435

 Score =  577 bits (1488), Expect = e-163,   Method: Composition-based stats.
 Identities = 215/431 (49%), Positives = 305/431 (70%)

Query: 2   SFNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKT 61
            +  II W SC+ +++R++L RP ++ +  I   V +I+ NVK  GD+AL +Y+  FDK 
Sbjct: 3   VYIPIIYWKSCSEKEKREILFRPVVNDNSQIKEVVKEIITNVKNSGDKALYDYTKTFDKI 62

Query: 62  TVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVT 121
            + +++VS  EI  +   +++E++++++VA  NI+ FH  Q    V++E QPGV C+Q+ 
Sbjct: 63  RLESIQVSYGEIVDSDSFVNEEIQKSISVAKNNIKIFHEKQTHNVVNIEIQPGVFCRQII 122

Query: 122 RPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDV 181
           RP+ SVGLYIPGG APL STVLMLA PA I GCK ++LCSPPPI  EILYA+++CG+ ++
Sbjct: 123 RPIQSVGLYIPGGCAPLVSTVLMLAIPAKIVGCKNIILCSPPPITKEILYASKICGIHNI 182

Query: 182 FNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLV 241
           F VGGAQAIAA+AFGT+++PKV+KIFGPGN +VTEAK Q++  L+  +IDM AGPSE+L+
Sbjct: 183 FQVGGAQAIAAMAFGTKTIPKVNKIFGPGNVYVTEAKLQINALLNDLSIDMLAGPSEILI 242

Query: 242 IADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQA 301
           IAD  A    +ASD LSQ EHG  SQ IL+TP+ D+A  V   +  QL  L R +   ++
Sbjct: 243 IADFKANACIIASDFLSQMEHGIYSQAILVTPSYDLACNVIFEINIQLKNLSRKKVINKS 302

Query: 302 LNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDY 361
           L  SR+IVTK L +C EISN Y PEHLIIQ  N+  L+  + +AGS+FLG WS  ++GDY
Sbjct: 303 LKYSRIIVTKTLLECFEISNLYAPEHLIIQCENSNRLLVYVINAGSIFLGRWSAVASGDY 362

Query: 362 ASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKN 421
            +GTNHVLPTYG     S L + DFQK ++VQ+L ++G   ++S+I +L+  ER+ AH N
Sbjct: 363 VTGTNHVLPTYGSAIVNSGLTVMDFQKIISVQKLDQQGLIDVSSSIISLSEVERMDAHTN 422

Query: 422 AVTLRVNALKE 432
           ++  R+ AL++
Sbjct: 423 SIKQRLIALQD 433


>UniRef50_Q722Y3 Histidinol dehydrogenase n=20 Tax=Firmicutes RepID=HISX_LISMF
          Length = 427

 Score =  575 bits (1483), Expect = e-162,   Method: Composition-based stats.
 Identities = 172/432 (39%), Positives = 248/432 (57%), Gaps = 9/432 (2%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
             I+       E   +L +    + S  +   V  I++ VK  GD+AL ++++KFD   +
Sbjct: 1   MKILTGT--VNELLNELKIETDTNTSIQVETEVKTIIEKVKTAGDQALFDFTSKFDGVGL 58

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRP 123
           T L+V A +I AAS ++      A+  A  NIE+FH+ QK        + GV   Q+ RP
Sbjct: 59  TELRVPAADIQAASAKIEPAFLDALQQAKVNIESFHSKQKQHAFLDSEKDGVIRGQLIRP 118

Query: 124 VASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP---PIADEILYAAQLCGVQD 180
           + +VG+Y+PGG+A   S+VLM   PA IAG K++V+ +PP    I   +L +AQL GV +
Sbjct: 119 LETVGVYVPGGTAAYPSSVLMNVLPAKIAGVKRIVMITPPGENGINPYVLASAQLAGVDE 178

Query: 181 VFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVL 240
           ++ VGGA  IAALA GTES+PKVDKI GPGN +V  AKR+V   +D   IDM AGPSE++
Sbjct: 179 IYQVGGAHGIAALAHGTESIPKVDKIVGPGNIYVATAKREVFGLVD---IDMIAGPSEIV 235

Query: 241 VIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQ 300
           V+AD  A P F+A+DLLSQAEH   ++ IL+T +  +A      +++QL  LPR   A++
Sbjct: 236 VLADENANPAFIAADLLSQAEHDILARAILITTSKKIAEETQNEIDKQLENLPRKAIAQK 295

Query: 301 ALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAG 359
           ++    ++I+     +  +I N+  PEHL +Q  N    +  I +AGS+FLG ++ E  G
Sbjct: 296 SIETRGKIIIAATTQEMFDIMNEIAPEHLEVQLENPMNYLYQIKNAGSIFLGSYASEPLG 355

Query: 360 DYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAH 419
           DY +G NHVLPT G     S LG+ DF KR      +KE  +     I  LA  E L AH
Sbjct: 356 DYFAGPNHVLPTSGTAKFFSPLGVEDFTKRSAFISYTKEALAKEKDAIVLLAKKEGLDAH 415

Query: 420 KNAVTLRVNALK 431
             A+ +R     
Sbjct: 416 AKAIQIRFEEEN 427


>UniRef50_A8RCE7 Putative uncharacterized protein n=1 Tax=Eubacterium dolichum DSM
           3991 RepID=A8RCE7_9FIRM
          Length = 427

 Score =  574 bits (1480), Expect = e-162,   Method: Composition-based stats.
 Identities = 177/429 (41%), Positives = 255/429 (59%), Gaps = 10/429 (2%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
               ++       Q +  +    +  + ++   V+ IL++V+  GDEA+  Y+ +FD   
Sbjct: 1   MLKQLNIEQID--QLQSYIEERRVVMNPALIGRVSAILEDVRMHGDEAVLRYTKQFDGME 58

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
           +  L+VS+EE+ A ++  + E +++M  A +NI  +H AQ      +E + G+   Q   
Sbjct: 59  LNKLRVSSEELNAQADLCTPEFRRSMQQAKENILFYHQAQISKGYRLEKEMGIYLGQRVL 118

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGV 178
           P+ SVG+Y+PGGSA   S+VLM A PA +AG K++V+ +PP     I   I  AA+L G+
Sbjct: 119 PLDSVGIYVPGGSAQYPSSVLMNALPARLAGVKRIVMLTPPSKEGSIHTNIALAAKLVGI 178

Query: 179 QDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSE 238
            +V+ VGGAQ IAALA+GT+S+ KVDKI GPGN +V  AK+ V   +D   IDM AGPSE
Sbjct: 179 DEVYKVGGAQGIAALAYGTQSIAKVDKIVGPGNVYVACAKKLVFGDVD---IDMIAGPSE 235

Query: 239 VLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETA 298
           +LVI D GA P ++A+DLLSQAEH P +  +LL  + +M   V + +++Q   LPR +  
Sbjct: 236 ILVIGDEGANPKWIAADLLSQAEHDPQASAVLLAVSQNMVDAVKQELQKQTRCLPRQKII 295

Query: 299 RQALNASRL-IVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPES 357
            ++L    L +V + L QCV+ISNQ  PEHL +      EL+  +  AGSVFLG  + ES
Sbjct: 296 HESLENYGLALVCESLQQCVDISNQIAPEHLELMVDKPEELLPLVRHAGSVFLGYATCES 355

Query: 358 AGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLT 417
            GDY  GTNHVLPT G     + LG+  F K+ +    S E   A   +I TLA AE+L 
Sbjct: 356 VGDYFGGTNHVLPTGGTARFFNPLGVDSFVKKSSYLHYSIEALQAYGDSIITLAEAEQLQ 415

Query: 418 AHKNAVTLR 426
           AH NAV +R
Sbjct: 416 AHANAVKVR 424


>UniRef50_Q02136 Histidinol dehydrogenase n=9 Tax=Bacteria RepID=HISX_LACLA
          Length = 431

 Score =  571 bits (1472), Expect = e-161,   Method: Composition-based stats.
 Identities = 164/435 (37%), Positives = 250/435 (57%), Gaps = 11/435 (2%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDK-- 60
               ID+     E+  +         S+ + +TV  I+ +++  GD AL  Y+ KFD   
Sbjct: 1   MLKQIDYQGK-LEEIAEKFQGRKTEVSKEVNKTVQQIVADIQKNGDTALFNYAKKFDGYD 59

Query: 61  TTVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQV 120
              + L V+  E  A  E++ ++  + +      IE FH  Q     ++  + GV   Q+
Sbjct: 60  VNTSNLLVTRMEREAGLEQIDEDYFRILRRTKSQIEEFHKHQLGNSWNIFKENGVIMGQI 119

Query: 121 TRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSP----PPIADEILYAAQLC 176
            RP+  V LY+PGG+A   STV+M A PA +AG K++++ +P      +   IL AA++C
Sbjct: 120 ARPLERVALYVPGGTAAYPSTVIMNAVPALLAGVKEIIMITPVKADGKVNPNILAAAEVC 179

Query: 177 GVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGP 236
           G++ ++ VGGAQ +AA+A+GTES+PKVDKI GPGN FV  AK+     +D   IDM AGP
Sbjct: 180 GIETIYKVGGAQGVAAVAYGTESIPKVDKIVGPGNIFVATAKKICYGVVD---IDMIAGP 236

Query: 237 SEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAE 296
           SEVLVIAD  A P ++A+DL++QAEH   +  IL+T +  + ++V E + RQ+  L R E
Sbjct: 237 SEVLVIADKTAKPKYIAADLMAQAEHDKLASAILVTTSEKLVQQVDEELNRQVQNLERRE 296

Query: 297 TARQAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSP 355
               ++ N    IV K++    ++SNQ  PEHL + T      +  I +AGS+F+G+++P
Sbjct: 297 IIESSIRNYGGAIVVKNIDDAFDVSNQLAPEHLEVLTSEPLTQLPKIKNAGSIFIGEYTP 356

Query: 356 ESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAER 415
           E  GDY SG+NHVLPT G     S LG+ +F K +T     KE  +     +ET A +E 
Sbjct: 357 EPLGDYMSGSNHVLPTGGTAKFYSGLGVYNFIKYLTYSYYPKEVLADFKEDVETFAKSEG 416

Query: 416 LTAHKNAVTLRVNAL 430
           LTAH N++++R + +
Sbjct: 417 LTAHANSISVRFDEM 431


>UniRef50_Q9C5U8 Histidinol dehydrogenase, chloroplastic n=34 Tax=cellular organisms
           RepID=HISX_ARATH
          Length = 466

 Score =  570 bits (1471), Expect = e-161,   Method: Composition-based stats.
 Identities = 209/435 (48%), Positives = 274/435 (62%), Gaps = 8/435 (1%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
                 +  ++ Q   L  RP I  S SI  TVN I+D V++ GD A++EY+ +FDK  +
Sbjct: 32  MKSYRLSELSSSQVDSLKSRPRIDFS-SIFATVNPIIDAVRSNGDNAVKEYTERFDKVQL 90

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRP 123
             +     E+  +   L   +K+A  VA  NI  FH AQK     VE   GVRC++V+R 
Sbjct: 91  NKVVEDMSEL--SVPELDSNVKEAFDVAYDNIYAFHLAQKSTEKSVENMKGVRCKRVSRS 148

Query: 124 VASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQ 179
           + SVGLY+PGG+A L ST LMLA PA IAGCK VVL +PP     I  E+LY A+  GV 
Sbjct: 149 IGSVGLYVPGGTAVLPSTALMLAIPAQIAGCKTVVLATPPSKDGSICKEVLYCAKRAGVT 208

Query: 180 DVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEV 239
            +   GGAQAIAA+A+GT+S PKV+KIFGPGN +VT AK  +       +IDMPAGPSEV
Sbjct: 209 HILKAGGAQAIAAMAWGTDSCPKVEKIFGPGNQYVTAAKMILQNSEAMVSIDMPAGPSEV 268

Query: 240 LVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADM-ARRVAEAVERQLAELPRAETA 298
           LVIAD  A+P ++A+DLLSQAEHGPDSQV+L+     +    + E + +Q   LPR E A
Sbjct: 269 LVIADEHASPVYIAADLLSQAEHGPDSQVVLVVVGDSVDLNAIEEEIAKQCKSLPRGEFA 328

Query: 299 RQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESA 358
            +AL+ S  +  +D+ + +  SN Y PEHLII  ++A +    I +AGSVF+G W+PES 
Sbjct: 329 SKALSHSFTVFARDMIEAISFSNLYAPEHLIINVKDAEKWEGLIENAGSVFIGPWTPESV 388

Query: 359 GDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTA 418
           GDYASGTNHVLPTYGY    S + L  F K MTVQ L++EG   L   + T+A  E L A
Sbjct: 389 GDYASGTNHVLPTYGYARMYSGVSLDSFLKFMTVQSLTEEGLRNLGPYVATMAEIEGLDA 448

Query: 419 HKNAVTLRVNALKEQ 433
           HK AVTLR+  ++ +
Sbjct: 449 HKRAVTLRLKDIEAK 463


>UniRef50_Q30TA4 Histidinol dehydrogenase n=16 Tax=Epsilonproteobacteria
           RepID=HISX_SULDN
          Length = 430

 Score =  570 bits (1470), Expect = e-161,   Method: Composition-based stats.
 Identities = 164/432 (37%), Positives = 249/432 (57%), Gaps = 11/432 (2%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
                  NS    + ++LL R  +  +  ++ TV  I+D +K+  ++AL+E+  KFDK T
Sbjct: 1   MIFTTSKNSSFKAEFKELLERGKMDIAH-VSATVGTIIDEIKSNKNQALKEHITKFDKWT 59

Query: 63  V---TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQ 119
                 LK+S E ++ A E L   LK A+ ++   I+ +H  QK      +   G    Q
Sbjct: 60  PVSDEDLKISTESMSRAYENLDKALKAALHLSYDRIKAYHEKQKPRSWFDDEPNGTILGQ 119

Query: 120 VTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLC 176
              PV S GLYIPGG A   S++LM   PA +AG + +V+C+P P     + +L A  LC
Sbjct: 120 RVTPVDSAGLYIPGGKAAYPSSLLMNVIPAQVAGVQNIVVCTPTPENEPNELLLAACHLC 179

Query: 177 GVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGP 236
           GV +V+ VGGA AIAA+A+GTE++PKVD I GPGN FV  AK+ V   ++   IDM AGP
Sbjct: 180 GVSEVYKVGGASAIAAMAYGTETIPKVDVITGPGNIFVATAKKMVFGDVN---IDMIAGP 236

Query: 237 SEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAE 296
           SE+ ++AD  A P  +A D+LSQAEH   +  IL+TP+  +A  +   +E  L  LPR +
Sbjct: 237 SEIGILADDSANPSHMAVDMLSQAEHDEMASSILITPSQKLADAIKAEIENWLKILPRQK 296

Query: 297 TARQALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSP 355
            AR+++     +IVT D+ + +++ N+  PEHL + T +  EL+  I  AG++FLG  +P
Sbjct: 297 IARESIEKRGAIIVTSDMQEAIDLMNEIAPEHLEVATLSPFELLPLIKHAGAIFLGHNTP 356

Query: 356 ESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAER 415
           E+ GDY +G NH LPT G     S LG+ +F K+ ++   S +  + +      +A  E 
Sbjct: 357 EAVGDYMAGPNHTLPTGGTAKFFSPLGVENFMKKTSIISFSAKAINEIGEECALIAKIEG 416

Query: 416 LTAHKNAVTLRV 427
           LTAH+ ++ +R+
Sbjct: 417 LTAHEQSIRVRL 428


>UniRef50_Q6FEC8 Histidinol dehydrogenase n=50 Tax=Bacteria RepID=HISX_ACIAD
          Length = 430

 Score =  568 bits (1466), Expect = e-161,   Method: Composition-based stats.
 Identities = 162/433 (37%), Positives = 246/433 (56%), Gaps = 10/433 (2%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKT- 61
               +     + +Q    L+         + +TV+ I+ +V+  GDE + + + +FD+  
Sbjct: 1   MMRRLSTQDQSFKQVFADLLAFETVNDPELLKTVDQIIADVRQYGDEHVLKLTQQFDRHP 60

Query: 62  --TVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQ 119
               + L+++ E++  A E L+ E+++A+ +A + I +FH AQK          G    Q
Sbjct: 61  AHQFSDLELTQEQLKTAFEALTAEIREALELAAERIRSFHQAQKQEGWSYVDALGNTLGQ 120

Query: 120 VTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLC 176
              P+  VG+Y+PGG A   S+VLM A PA +AG  ++++  P P   +   +L AA L 
Sbjct: 121 KVTPLDRVGIYVPGGLASYPSSVLMNAIPAHVAGVPEIIMVVPAPNGELNSLVLAAAYLA 180

Query: 177 GVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGP 236
           GV  +F +GGAQA+AALA+GT+++P VDKI GPGN FV  AKR V  ++    IDM AGP
Sbjct: 181 GVSRIFTIGGAQAVAALAYGTQTIPAVDKITGPGNRFVAAAKRAVFGQV---GIDMIAGP 237

Query: 237 SEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAE 296
           SE+LV A+      ++A DLLSQAEH   +Q I +TP   +   VA+A+E  LA LP+A+
Sbjct: 238 SEILVYAEGQNNAKWLAMDLLSQAEHDTVAQAIFITPDEALLDEVAQAIEEHLAALPKAD 297

Query: 297 TARQALNA-SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSP 355
            AR ++     L++ KD  + +E+ NQ  PEHL +    +  +   I  AG++F+G ++P
Sbjct: 298 IARTSIANRGALVLVKDRDEAIELINQVAPEHLELCLDESEAMSQKIRHAGAIFMGRYTP 357

Query: 356 ESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAER 415
           E+ GDY +G NHVLPT G     S LG+ DFQKR ++   S+EG  +LA   + LA  E 
Sbjct: 358 EAIGDYCAGPNHVLPTSGTARFSSPLGVYDFQKRSSLIMCSQEGVKSLAKAADVLAQQEN 417

Query: 416 LTAHKNAVTLRVN 428
           L AH  +   R  
Sbjct: 418 LDAHARSARYRYQ 430


>UniRef50_Q8YSM8 Histidinol dehydrogenase 1 n=16 Tax=Bacteria RepID=HISX1_ANASP
          Length = 431

 Score =  568 bits (1464), Expect = e-160,   Method: Composition-based stats.
 Identities = 173/433 (39%), Positives = 255/433 (58%), Gaps = 7/433 (1%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
             ++         + Q L+     A+  ++ TV DIL +VKARGD A++EY+++FD    
Sbjct: 1   MLVLKTTDKEFSPRFQSLVSDRREATVDVSGTVRDILAHVKARGDAAVQEYTSRFDHYRP 60

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRP 123
            +  +SA  IA  + + SDE+K A+ +A + I +FH  Q    +      GV+       
Sbjct: 61  HSHHLSAAFIAEQAAKCSDEVKAALELAAERISSFHQKQLPQDIGYTDTAGVKLGLNWVA 120

Query: 124 VASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSP---PPIADEILYAAQLCGVQD 180
           ++ VG+Y+PGG A   S+VLM A PA IAG +++V+  P     I   +L AAQ+ GV +
Sbjct: 121 LSQVGIYVPGGRASYPSSVLMNALPAKIAGVERIVMTVPMPHGEINPAVLAAAQVAGVTE 180

Query: 181 VFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVL 240
           ++++GGAQA+ ALA+GTE++  VDKI GPGNA+V EAKRQV   +    ID  AGPSE+L
Sbjct: 181 IYSIGGAQAVGALAYGTETITPVDKIVGPGNAYVAEAKRQVFGTV---GIDSIAGPSEIL 237

Query: 241 VIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQ 300
           V+AD    P+++A DLLSQAEH P +Q IL+T +   A++V  AVE+ L  LP  + A  
Sbjct: 238 VVADRQNNPEWIAWDLLSQAEHDPSAQSILITDSESFAQQVIAAVEQILTTLPSQKVASS 297

Query: 301 AL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAG 359
           +  N   +I+ +DLA+ + + NQ  PEH+ +   N + L   I  AGS+FLG ++PE+ G
Sbjct: 298 SWQNHGAVIIVRDLAESIPLLNQLAPEHVELCVDNPQLLASQIKCAGSLFLGRYTPEAIG 357

Query: 360 DYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAH 419
           DY  G NHVLPT       S L + DF KR+T  E ++     +  +  TLA  E L AH
Sbjct: 358 DYLGGPNHVLPTSRSARFASGLSVYDFLKRITYLECNQAALQKIGQSAVTLAETEGLPAH 417

Query: 420 KNAVTLRVNALKE 432
             +V +R+  LK+
Sbjct: 418 AGSVAVRLQGLKD 430


>UniRef50_D1CF70 Histidinol dehydrogenase n=1 Tax=Thermobaculum terrenum ATCC
           BAA-798 RepID=D1CF70_THET1
          Length = 433

 Score =  568 bits (1464), Expect = e-160,   Method: Composition-based stats.
 Identities = 186/429 (43%), Positives = 273/429 (63%), Gaps = 9/429 (2%)

Query: 5   TIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVT 64
             I     + E++R+L  R   + S  +T  V  I+++V+ +GDE++REY+ +FD   + 
Sbjct: 8   RTIRLADLSPEERRRLTHRSG-AISMDVTSVVRQIVEDVRQKGDESVREYTERFDGVKLD 66

Query: 65  ALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPV 124
           +L+V   EI  A +R+   L +AM++A  NI  FH+AQ  P   VET PGV+  +V RP+
Sbjct: 67  SLEVPRVEIETALDRIDQHLAEAMSIAASNIRAFHSAQIHPEPVVETSPGVKVWRVWRPI 126

Query: 125 ASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQD 180
             VG+Y+PGG A   STVLM A PAS+AGC ++VLC+PP     + +  L AA L GV  
Sbjct: 127 ERVGVYVPGGGARYPSTVLMHAVPASVAGCSEIVLCTPPGPDGKVPEATLAAAALSGVTR 186

Query: 181 VFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVL 240
           VF++GGAQAIAA+A+GT+++P V KIFGPGN +VT AK  V   +D   ID PAGPSE++
Sbjct: 187 VFSIGGAQAIAAMAYGTQTIPPVQKIFGPGNVYVTAAKMLVFGDVD---IDKPAGPSELV 243

Query: 241 VIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQ 300
           +IAD  A P   A+DL++Q+EH PD+  +L+T +  +A  V   + RQL +LP  +    
Sbjct: 244 IIADDTADPRETAADLIAQSEHAPDNASVLVTTSESLAEAVLSELTRQLEDLPNRDRVIS 303

Query: 301 AL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAG 359
           +  +   +++ +DLAQ V   N+Y PEHL I T + RE+++ I +AGS+FLG +SP  AG
Sbjct: 304 SFRSNGFILLVEDLAQAVGFVNEYAPEHLQIVTVSPREILEGINNAGSIFLGRYSPVPAG 363

Query: 360 DYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAH 419
           DYA G+NHVLPT G   T   L   +F K + VQEL++EG  ++++ +  +A AE L  H
Sbjct: 364 DYAVGSNHVLPTSGSARTFGPLSTEEFGKWVQVQELTQEGLRSISNAVTAMARAENLEGH 423

Query: 420 KNAVTLRVN 428
             A+ +R +
Sbjct: 424 ARAIEVRFS 432


>UniRef50_Q4ZNV9 Histidinol dehydrogenase n=116 Tax=Bacteria RepID=HISX_PSEU2
          Length = 448

 Score =  565 bits (1456), Expect = e-159,   Method: Composition-based stats.
 Identities = 165/435 (37%), Positives = 240/435 (55%), Gaps = 10/435 (2%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDK--- 60
              +D       +    L+     + +S+ + V DI+  V+ RGD AL E++ KFD    
Sbjct: 7   IRRLDAADPDFARHLDHLLSWESVSDDSVNQRVLDIIKAVRERGDAALVEFTQKFDGLQV 66

Query: 61  TTVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQV 120
            ++  L +  E +  A  R++   ++A+  A + + ++H  QK          G    Q 
Sbjct: 67  ASMADLILPRERLELALTRITPGQREALEKAAERVRSYHEKQKQDSWSYTEADGTVLGQK 126

Query: 121 TRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCG 177
             P+   GLY+PGG A   S+VLM A PA +AG  +VV+  P P   I + +L AA + G
Sbjct: 127 VTPLDRAGLYVPGGKASYPSSVLMNAIPAKVAGVTEVVMVVPTPRGEINELVLAAACIAG 186

Query: 178 VQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPS 237
           V  VF +GGAQA+AALA+GTESVPKVDK+ GPGN +V  AKR V  ++    IDM AGPS
Sbjct: 187 VDRVFTIGGAQAVAALAYGTESVPKVDKVVGPGNIYVATAKRHVFGQV---GIDMIAGPS 243

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAET 297
           E+LV+ D    PD++A DL SQAEH  D+Q IL++P A+   +VA ++ R L  + RA  
Sbjct: 244 EILVVCDGQTDPDWIAMDLFSQAEHDEDAQAILVSPDAEFLDKVAASITRLLPTMERAAI 303

Query: 298 ARQALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPE 356
              ++N    LI   D+AQ +E++N+  PEHL +   +    +  I  AG++F+G  + E
Sbjct: 304 VETSINGRGALIKVADMAQAIEVANRIAPEHLELSVADPEAWLPQIRHAGAIFMGRHTSE 363

Query: 357 SAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERL 416
           + GDY +G NHVLPT G     S LG+ DFQKR ++   S +G S L  T   LA  E L
Sbjct: 364 ALGDYCAGPNHVLPTSGTARFSSPLGVYDFQKRSSIIYCSPQGASELGKTASVLARGESL 423

Query: 417 TAHKNAVTLRVNALK 431
           + H  +   R+    
Sbjct: 424 SGHARSAEYRITDPD 438


>UniRef50_C0GFZ9 Histidinol dehydrogenase n=1 Tax=Dethiobacter alkaliphilus AHT 1
           RepID=C0GFZ9_9FIRM
          Length = 432

 Score =  564 bits (1455), Expect = e-159,   Method: Composition-based stats.
 Identities = 183/431 (42%), Positives = 244/431 (56%), Gaps = 8/431 (1%)

Query: 9   WNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKV 68
                    R+   R         T+ V DIL  V  RGDEA+ EY+ KFD   +  L V
Sbjct: 2   LREFDGRTFRETFTRAGFDDYPEATQAVRDILAEVNQRGDEAVLEYTRKFDGVELETLLV 61

Query: 69  SAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVG 128
           S EE AAA E +  E++Q++  A +NI  FH  Q           GV   Q    V   G
Sbjct: 62  SEEEFAAAEEAVDPEVRQSLVEAAENIRDFHRRQVQNSWLEHQADGVALGQRVTAVEKAG 121

Query: 129 LYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQDVFNV 184
            Y+PGG A   S+VLM   PA +AG +KVVL +PP     I    L AA++ G   V+  
Sbjct: 122 AYVPGGGAAYPSSVLMTVIPARVAGVEKVVLVTPPQAGGEINPYTLVAAKIAGADAVYKC 181

Query: 185 GGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIAD 244
           GGAQA+AALA+GTE+VPKVDKI GPGN +VT AKR+VS  +    IDM AGPSEVLV+AD
Sbjct: 182 GGAQAVAALAYGTETVPKVDKIVGPGNLYVTLAKREVSGMV---GIDMLAGPSEVLVVAD 238

Query: 245 SGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-N 303
           + A  DFVA+DLLSQAEH   +    +T +A +A  + + ++RQ A+L R + AR++L  
Sbjct: 239 ASARADFVAADLLSQAEHDVMAASYCVTTSARLALDLQKELKRQCAQLERCDVARESLQQ 298

Query: 304 ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYAS 363
              L++   L + +EI N+  PEHL +Q     E +  + +AG+VF+G ++PE  GDY +
Sbjct: 299 QGALVIVDSLDEALEIVNELAPEHLELQLSEPWEALGKVKNAGAVFVGPYTPEPVGDYWA 358

Query: 364 GTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAV 423
           G NHVLPT G     S L + DF K+ +V   S +     A  IE LA  E LTAH  AV
Sbjct: 359 GPNHVLPTAGAGRFSSVLSVDDFVKKTSVIYYSPQALLKSAQKIEGLARVEGLTAHGQAV 418

Query: 424 TLRVNALKEQA 434
            +R   L+E+ 
Sbjct: 419 KIRREYLEEKG 429


>UniRef50_Q46J19 Histidinol dehydrogenase n=60 Tax=Bacteria RepID=HISX_PROMT
          Length = 449

 Score =  563 bits (1452), Expect = e-159,   Method: Composition-based stats.
 Identities = 159/431 (36%), Positives = 249/431 (57%), Gaps = 8/431 (1%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
               +       + R++  R + +  +   + V+DIL NV+ RGDEAL EY+++FD    
Sbjct: 20  IKTANSIDQAQFELRKITERTSGTVQDEAIKVVDDILKNVRERGDEALTEYTSRFDGFLT 79

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRP 123
              +VS++ I  A E    EL+ ++ +A K IE FH+ Q    +      G    +   P
Sbjct: 80  EKFQVSSDLILKAWEETPRELQDSLLLAKKRIEKFHSLQVPKNITYTGPNGETLGRRWSP 139

Query: 124 VASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSP----PPIADEILYAAQLCGVQ 179
           V   G+Y+PGG A   STVLM A PA +AG  ++++ SP      I   +L AA + G+ 
Sbjct: 140 VEKAGIYVPGGRAAYPSTVLMNAIPAYVAGVNQIIMVSPANSQGEINQTVLAAAHITGIN 199

Query: 180 DVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEV 239
            +F +GGAQAI ALA GTES+PKVD I GPGN +VT AK++V  ++    ID  AGPSE+
Sbjct: 200 KIFRLGGAQAICALASGTESIPKVDVITGPGNIYVTLAKKKVYGKV---GIDSLAGPSEI 256

Query: 240 LVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETAR 299
           L+IAD  A  + VASD+L+Q+EH P +  IL+T    +A ++   + RQL   PR +  +
Sbjct: 257 LIIADQSAKLEHVASDMLAQSEHDPLASAILITTNTKLAEKLPAEINRQLINHPRLKICQ 316

Query: 300 QALNA-SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESA 358
           ++++    +++  DL  C ++S+ + PEHL +   + ++L +SI +AG++F+G WSPE+ 
Sbjct: 317 ESISNWGLIVLCDDLETCAQLSDTFAPEHLELLVEDPKKLSESINNAGAIFMGPWSPEAI 376

Query: 359 GDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTA 418
           GDY  G NH LPT G      +LG+  F K  ++ + SKE F+   + +  LA +E L +
Sbjct: 377 GDYLGGPNHTLPTSGTARFAGALGVETFMKNTSLIDFSKEAFNENKNAVVQLANSEGLHS 436

Query: 419 HKNAVTLRVNA 429
           H  ++ +R + 
Sbjct: 437 HAESIRIRDSK 447


>UniRef50_P59399 Histidinol dehydrogenase n=14 Tax=Bacteria RepID=HISX_LACPL
          Length = 428

 Score =  561 bits (1447), Expect = e-158,   Method: Composition-based stats.
 Identities = 175/431 (40%), Positives = 250/431 (58%), Gaps = 9/431 (2%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
             II+     A  +R +  +        +   V +I+ NV   GD A+++Y  +FDK T+
Sbjct: 1   MKIIN--EDLASLKRLVQTKTQQLTDLKVESAVREIIANVIKNGDAAVKDYETQFDKVTL 58

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRP 123
           T  K+S   I  A   L  ++K A+ +A +NI +FH  +K        QPGV   Q   P
Sbjct: 59  TDFKLSQTVIDDAYNNLDPQVKDALLLAKRNITSFHEKEKATGFIDAEQPGVLRGQKLMP 118

Query: 124 VASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP---PIADEILYAAQLCGVQD 180
           +  VGLY+PGG+A   ST+LM A PA IAG  +V++ +PP    I   +L AA++ GV  
Sbjct: 119 LNRVGLYVPGGTAAYPSTLLMSALPAKIAGVNEVIMVTPPQVDGINPAVLAAAKIAGVDA 178

Query: 181 VFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVL 240
           ++ VGGAQAIAALA+GTES+P VDKI GPGN FV  AK+QV  ++   AIDM AGPSE+ 
Sbjct: 179 IYQVGGAQAIAALAYGTESIPAVDKIIGPGNIFVATAKKQVFGQV---AIDMVAGPSEIG 235

Query: 241 VIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQ 300
           ++AD  A P  +A+DLLSQAEH   ++ IL+T +AD+A+ V++ V  QL  LPR   A  
Sbjct: 236 ILADDSADPRQLAADLLSQAEHDRRARPILITDSADLAQAVSDNVTSQLKVLPREAIATD 295

Query: 301 AL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAG 359
           A+     + V   + +  ++ N   PEHL +Q +N  + ++ I +AGSVFLG ++ E  G
Sbjct: 296 AVNEKGFIAVVAKIEEMFDLMNTVAPEHLEVQLKNPTQYLNLIKNAGSVFLGRYASEPLG 355

Query: 360 DYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAH 419
           DY +G NH+LPT G     S LG+ DF KR +  + +K+  +  A  I TLA  E L  H
Sbjct: 356 DYVAGPNHILPTSGTARFSSPLGVYDFVKRTSFIQYTKDALAKEAPAITTLARVEGLEGH 415

Query: 420 KNAVTLRVNAL 430
             A+  R +  
Sbjct: 416 ARAIESRFDTY 426


>UniRef50_C6Y3G2 Histidinol dehydrogenase n=6 Tax=cellular organisms
           RepID=C6Y3G2_PEDHD
          Length = 430

 Score =  561 bits (1447), Expect = e-158,   Method: Composition-based stats.
 Identities = 198/432 (45%), Positives = 277/432 (64%), Gaps = 6/432 (1%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
             I  +   T ++  ++ +R  +    +I   V  I++ VK  GD+AL +Y+  FD+  +
Sbjct: 1   MKIYSYKDLTKQEVEEICLR-QLEDDVNIQERVKSIVERVKMEGDKALFDYALSFDQIRL 59

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRP 123
             L +  +EI   +  +  E K A+  A +NI+TFH +Q L    VET PGV C + TR 
Sbjct: 60  EELFIDQQEIMTIAATIPAEAKAAIDTAYQNIKTFHASQLLQEDKVETMPGVTCWRETRA 119

Query: 124 VASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIAD----EILYAAQLCGVQ 179
           +  VGLYIPGG+A L ST LML  PA +AGCK++V+CSPP         + Y A L G++
Sbjct: 120 IERVGLYIPGGTAVLPSTFLMLGIPAVLAGCKEIVVCSPPQKDGKTNCYLAYVATLLGIE 179

Query: 180 DVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEV 239
            ++ VGGAQA+AA+A+GT SVPKVDK+FGPGN +VT+AK+ +       AIDMPAGPSEV
Sbjct: 180 RIYLVGGAQAVAAMAYGTASVPKVDKVFGPGNRYVTQAKQLIQGNT-MTAIDMPAGPSEV 238

Query: 240 LVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETAR 299
           LV+AD  A P ++ASDLL+QAEHG DSQ IL+  ++ +     E +  QL  LPRA  A 
Sbjct: 239 LVLADETAIPSYIASDLLAQAEHGIDSQTILVATSSKIIDETMEQLALQLQVLPRAAFAT 298

Query: 300 QALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAG 359
           +A+  S  ++  DL + ++ SN Y PEHLI+ T N   L+  I++AGSVFLG+ +PESAG
Sbjct: 299 KAIENSYSVLVNDLEEGMKFSNVYAPEHLILATDNCERLIPLISNAGSVFLGNLTPESAG 358

Query: 360 DYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAH 419
           DYASGTNH LPT GY    S + +  F K++T Q ++ +G   + +T+E LAAAE L AH
Sbjct: 359 DYASGTNHTLPTSGYARAYSGVSMDSFMKKITFQHITTQGLRHIGNTVEVLAAAEGLDAH 418

Query: 420 KNAVTLRVNALK 431
           KNAV++R+ +L 
Sbjct: 419 KNAVSIRLKSLD 430


>UniRef50_B9D1F9 Histidinol dehydrogenase n=2 Tax=Campylobacter RepID=B9D1F9_WOLRE
          Length = 431

 Score =  560 bits (1445), Expect = e-158,   Method: Composition-based stats.
 Identities = 159/434 (36%), Positives = 246/434 (56%), Gaps = 9/434 (2%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
              +  ++   +     L+  +     ++T  V+ IL++V+ARGDEAL E   KFD+   
Sbjct: 1   MKFLLTSNENFKDYFAALVNRSNGDMSAVTPAVSQILEDVRARGDEALFEQIEKFDRWKP 60

Query: 64  T--ALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVT 121
              +LK+  EE+  A + +   L+ A+ +A + I+++H            + GV      
Sbjct: 61  DTNSLKIGTEEMQKAYDGIDSCLRNALNLAFERIKSYHEKSLPKTWMEHDEHGVLLGAKY 120

Query: 122 RPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSP---PPIADEILYAAQLCGV 178
            P+   GLYIPGG A   S++LM A PA +AG  ++ +C+P     +   +L A  +CG+
Sbjct: 121 TPLDRAGLYIPGGKAAYPSSLLMNAVPALVAGVGEIAVCTPAVGGKVNTLLLAAMHICGI 180

Query: 179 QDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSE 238
           ++ + VGGA A+AA+A+GT+++ K D I GPGN +V  AK+ V   ++   IDM AGPSE
Sbjct: 181 KEAYKVGGASAVAAMAYGTQTIKKTDVITGPGNIYVATAKKLVYGEVN---IDMIAGPSE 237

Query: 239 VLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETA 298
           + VIAD  A P  +A DLLSQAEH   +  +L+TP       V   +  ++  L R   A
Sbjct: 238 ICVIADESADPRHIAVDLLSQAEHDEMASAVLITPNQAFGAAVQRHINEEIKTLARQPIA 297

Query: 299 RQALNA-SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPES 357
           + +++    +IV  DL +CV ++N+  PEHL I T +A EL   I  AG++F+G ++PE+
Sbjct: 298 QASIDKKGAIIVASDLGECVRLANELAPEHLEIATNDAMELARQIRHAGAIFIGHFTPEA 357

Query: 358 AGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLT 417
            GDY +G NH LPT G     S LG+ +F KR ++  L+ +G S LA+    LA AE L 
Sbjct: 358 MGDYLAGPNHTLPTGGSARFYSPLGVENFMKRTSLISLNAKGISELANACMELAEAEGLG 417

Query: 418 AHKNAVTLRVNALK 431
           AH+ +V +R+ ALK
Sbjct: 418 AHRRSVVVRLEALK 431


>UniRef50_B0TY46 Histidinol dehydrogenase n=2 Tax=Francisella philomiragia
           RepID=B0TY46_FRAP2
          Length = 432

 Score =  559 bits (1441), Expect = e-158,   Method: Composition-based stats.
 Identities = 191/432 (44%), Positives = 276/432 (63%), Gaps = 4/432 (0%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              I +W   +  +Q +LL RP  +   S+   V +IL+ VK  GD+AL E++++FD   
Sbjct: 1   MIEIYNWQELSLVKQAELLSRPVSANKASLVAGVRNILNAVKQNGDKALLEFTSRFDGVD 60

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
           +  ++VSA EI  A   +S +  + +  ++  I  +H   K      +T  GV C+++ +
Sbjct: 61  LDNIEVSAHEIKEAYSLVSQDDIELVKNSIARISNYHEVMKPKTTVCDTNDGVVCKKIYK 120

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSP----PPIADEILYAAQLCGV 178
           P+  VGLY+PGGSAPL ST++MLA PA IAGCK++ + +P      I   IL AA +C V
Sbjct: 121 PIEKVGLYVPGGSAPLVSTLIMLAAPAQIAGCKEIYVTTPCDKEGNIHPLILIAADICKV 180

Query: 179 QDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSE 238
             ++ +GGAQAIAALA+GTE+V KV+KI+GPGN++VTEAK+QVS    GAAID+PAGPSE
Sbjct: 181 SKIYKLGGAQAIAALAYGTETVTKVNKIYGPGNSWVTEAKQQVSNDSQGAAIDLPAGPSE 240

Query: 239 VLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETA 298
           VLV+AD  A   FVA+DLL+QAEHG DSQ +L+T +  +A +V + V +Q +   R    
Sbjct: 241 VLVVADEVADARFVAADLLAQAEHGTDSQALLITTSQILADKVRDEVSKQTSTAQRKAII 300

Query: 299 RQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESA 358
            +AL  S +IV   L+Q + I+N+Y  EHLI+    A   +DSI +AG+VF+G W+ E+ 
Sbjct: 301 EKALENSAIIVVDTLSQAINIANEYASEHLILNIETADNYIDSIENAGAVFVGPWAAEAL 360

Query: 359 GDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTA 418
           GDY +G+NHVLPTYGY    S L   DF K +++Q +SK+G   +      LA  E L A
Sbjct: 361 GDYITGSNHVLPTYGYAKAYSGLATIDFMKAISIQNVSKQGIKNIGQIAMRLADIEGLKA 420

Query: 419 HKNAVTLRVNAL 430
           H+NA+ +R+ +L
Sbjct: 421 HENAIAIRLESL 432


>UniRef50_D0RRH1 Histidinol dehydrogenase n=1 Tax=alpha proteobacterium HIMB114
           RepID=D0RRH1_9RICK
          Length = 429

 Score =  557 bits (1436), Expect = e-157,   Method: Composition-based stats.
 Identities = 159/431 (36%), Positives = 247/431 (57%), Gaps = 9/431 (2%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT- 62
             I++  +   ++   L++      S +  + V  I+ ++K  GD AL +Y+ +FDK   
Sbjct: 1   MKILNTKNKLFKKNFDLVLSSKRIQSNNSQKIVKKIISDIKKNGDLALIKYTKRFDKVNF 60

Query: 63  -VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVT 121
             + +K+  + I+   ++L   +K+++ +A   I  FH  Q       + + G +     
Sbjct: 61  GPSKIKLDDKLISKKIKKLDINIKKSIDLAFNRITKFHKKQVHKGFKFKDKLGNQLGYKI 120

Query: 122 RPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCGV 178
            P+  VG+Y+PGG+A   ST+LM + PA +AG K +    P P   I   +LYAA+ C +
Sbjct: 121 LPLDKVGVYVPGGTASYPSTLLMNSIPAMVAGVKNIYCVMPTPKDEINAGVLYAAKKCKI 180

Query: 179 QDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSE 238
           + +F +GGAQA+AAL +GT++VPKVDKI GPGN FV  AK++V   +    IDM AGPSE
Sbjct: 181 KSIFRIGGAQAVAALTYGTKNVPKVDKIVGPGNIFVATAKKEVFGTV---GIDMVAGPSE 237

Query: 239 VLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETA 298
           + VIAD     D+ A DLLSQAEH   SQ ILLT +   A++V+  V++ L  LPR + A
Sbjct: 238 ITVIADDRNRADWTAVDLLSQAEHDVLSQSILLTTSEKFAKQVSLEVKKILKTLPRKKIA 297

Query: 299 RQALNA-SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPES 357
            +++     ++V K+  + V+ +N   PEHL I+ + + +L   I +AGS+FLG++SPE+
Sbjct: 298 SKSIKNYGCIVVCKNKKELVDYANIIAPEHLEIKIKGSEKLEKQIKNAGSIFLGEFSPEA 357

Query: 358 AGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLT 417
            GDY +G NHVLPT G     S L + DF KR ++ + +K G   +      LA  E L 
Sbjct: 358 IGDYLAGPNHVLPTSGSARFASGLSVNDFLKRTSLIKCTKRGIEKIGQMAINLANYEGLH 417

Query: 418 AHKNAVTLRVN 428
           AH  +V+ R+ 
Sbjct: 418 AHALSVSKRIK 428


>UniRef50_A9NV24 Histidinol dehydrogenase n=2 Tax=Spermatophyta RepID=A9NV24_PICSI
          Length = 491

 Score =  557 bits (1435), Expect = e-157,   Method: Composition-based stats.
 Identities = 197/443 (44%), Positives = 265/443 (59%), Gaps = 15/443 (3%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
                     + Q   L  RP I  S S+   V  I+++V+ RGD A+ +Y+ KFD   +
Sbjct: 50  MKTYRLADLHSTQIDHLKARPRIDFS-SMFGVVGPIIEDVRKRGDVAVIDYTTKFDGVNL 108

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQP-------GVR 116
             +     ++     +L   ++ A  VA  NI  FH AQ+ P   VE          GV 
Sbjct: 109 DKVVECVADLPD--PKLDSAVQAAFDVAYDNIRAFHAAQRNPERVVENMKVGSVLGRGVM 166

Query: 117 CQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYA 172
           C++V R + SVGLY+PGG+A L ST LMLA PA +AGC+ ++L SPP     I  E+LY 
Sbjct: 167 CKRVARSIDSVGLYVPGGTAVLPSTALMLAVPAQLAGCRIIILASPPRPDGSICKEVLYC 226

Query: 173 AQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDM 232
           A+  GV  +   GGAQAI+A+A+GT S PKV+KI GPGN +VT AK  +       +IDM
Sbjct: 227 AKKAGVTHILKAGGAQAISAMAWGTTSCPKVEKILGPGNQYVTAAKMILQNSEAMISIDM 286

Query: 233 PAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADM-ARRVAEAVERQLAE 291
           PAGPSEVLVIAD  A P ++A+DLLSQAEHGPDSQV+L+     +    +   +E+Q   
Sbjct: 287 PAGPSEVLVIADKHANPVYIAADLLSQAEHGPDSQVVLVLVGEGVNLDEIEMELEKQCKS 346

Query: 292 LPRAETARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLG 351
           LPR + A +AL  S  ++ ++ A+ +  SN Y PEHLII   +A + VD I +AGSVFLG
Sbjct: 347 LPRGQFAAKALTHSFTVLARNKAEAISFSNLYAPEHLIINVEDADQWVDYIENAGSVFLG 406

Query: 352 DWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLA 411
            WSPES GDYASGTNHVLPTYGY      + L  F K +TVQ L++EG  +L   +  +A
Sbjct: 407 RWSPESIGDYASGTNHVLPTYGYARMYGGVSLDSFMKYITVQSLTEEGLKSLGPHVVKMA 466

Query: 412 AAERLTAHKNAVTLRVNALKEQA 434
             E L AHK AVTLR+  ++ ++
Sbjct: 467 EVEGLEAHKRAVTLRLQDIETRS 489


>UniRef50_D0JBA3 Histidinol dehydrogenase n=2 Tax=Blattabacterium RepID=D0JBA3_BLASB
          Length = 435

 Score =  554 bits (1428), Expect = e-156,   Method: Composition-based stats.
 Identities = 183/431 (42%), Positives = 268/431 (62%), Gaps = 9/431 (2%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              +      T +  + +L R +   S  +T  V  I++NVK  GD A++ Y+ K+D   
Sbjct: 4   MIQVY--IHPTYKTCQSILNRSSEKISH-LTDLVLSIINNVKNNGDTAVKTYTRKYDHVD 60

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
           +  ++V+ E+   A+ ++S  L++++ +A KNIE FH  Q      +E   GV C + + 
Sbjct: 61  IKHIQVTEEDFQKANMKVSSHLRKSIEIAYKNIECFHKKQIHEESKIEVSTGVFCWRKSV 120

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGV 178
           P+  VG YIPGGSAPL STVLML  P  +AGCK +VLCSPP     I   +LY A+  G+
Sbjct: 121 PIEKVGFYIPGGSAPLLSTVLMLGVPGKLAGCKNIVLCSPPNKNGEIHPSVLYTAKYVGI 180

Query: 179 QDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSE 238
             ++ VGG QAIAA+A+GTES+P V KIFGPGN +VT AK+ VSQ+    +IDMPAGPSE
Sbjct: 181 NQIYKVGGVQAIAAMAYGTESIPSVYKIFGPGNCYVTIAKQIVSQK-GIVSIDMPAGPSE 239

Query: 239 VLVIADSGATPDFVASDLLSQAEHGPDSQVILLT-PAADMARRVAEAVERQLAELPRAET 297
           V+++AD  A P +VASDLLSQ+EH P+S ++L+T        +V E +++Q   L + + 
Sbjct: 240 VVIMADDEANPKYVASDLLSQSEHDPESYILLVTINNKSWIEKVKEELKKQFYHLSKKKI 299

Query: 298 ARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPES 357
             +    S+++V   L +C+   NQ  PEHLII   N     + + +AGSVFLG++SP S
Sbjct: 300 LLKIFRKSKIVVFSSLEECMNFINQVAPEHLIINCNNVSYWSEKVINAGSVFLGNYSPVS 359

Query: 358 AGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLT 417
            GDYASGTNHVLPTYGY  + S + +  F K++T Q++SK+G   L+  +  L++ E L 
Sbjct: 360 IGDYASGTNHVLPTYGYAKSYSGVSVDSFVKKITFQKISKKGLQNLSECVNVLSSEEGLI 419

Query: 418 AHKNAVTLRVN 428
           AHK ++ +R+ 
Sbjct: 420 AHKKSIDIRLK 430


>UniRef50_C9LTV1 Histidinol dehydrogenase n=1 Tax=Selenomonas sputigena ATCC 35185
           RepID=C9LTV1_9FIRM
          Length = 449

 Score =  553 bits (1427), Expect = e-156,   Method: Composition-based stats.
 Identities = 164/452 (36%), Positives = 245/452 (54%), Gaps = 26/452 (5%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISA---SESITRTVNDI--------------LDNVKAR 46
             I+       ++ R+LL++P       +  I      I              +++V+  
Sbjct: 1   MKIVSAKELGKDKIRKLLVKPPFDEVQLNPKIREANRKIFGADLTAAEVAVRIVEDVRRH 60

Query: 47  GDEALREYSAKFDKTT--VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKL 104
           GDEA+ +Y+   D T       +VS EE A A +     +  ++  A  N+ ++H  QK 
Sbjct: 61  GDEAVIKYTKLIDGTDFSPEDFQVSEEEFAEAEKNADPAIVASLQRAAHNVRSYHEEQKA 120

Query: 105 PPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP 164
                  + G    Q   P+   G+Y+PGG+A   S+VLM A PA++AG  ++++  PP 
Sbjct: 121 NSWLTYREKGSILGQSLIPLDRAGIYVPGGTAAYPSSVLMNAVPAAVAGVGEIIMMVPPK 180

Query: 165 ---IADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQV 221
              I   +L AA++ GV  V+ +GGAQAIAA+A+GT ++P+VDKI GPGN FVT AK+ V
Sbjct: 181 NGKINPYVLLAAKIAGVSKVYKIGGAQAIAAMAYGTATIPRVDKITGPGNIFVTLAKKAV 240

Query: 222 SQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRV 281
               D   IDM AGPSE+L++AD  A P + A+D+LSQAEH   +  IL+T +A +A  V
Sbjct: 241 YGHCD---IDMLAGPSEILIVADETADPAYTAADMLSQAEHDTLASSILITTSAKLAHEV 297

Query: 282 AEAVERQLAELPRAETARQALNA-SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVD 340
              +E QL  LPR   AR ++     +++  D+ + +E +N   PEH+ + T+   EL+ 
Sbjct: 298 EALLEEQLKGLPRENIARASIENNGLIVIADDIMEALEYANISAPEHMELLTKQPFELLP 357

Query: 341 SITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGF 400
            +  AG+VFLG +SPE  GDY +G NHVLPT G     S L +  F KR ++   +K+  
Sbjct: 358 YVRHAGAVFLGAYSPEPLGDYFAGPNHVLPTGGTARFYSVLNVETFMKRTSIISYTKDAL 417

Query: 401 SALASTIETLAAAERLTAHKNAVTLRVNALKE 432
             + + I  LA AE L AH NAV LR    K+
Sbjct: 418 HDVEADIIRLAEAEGLHAHANAVRLRSKERKD 449


>UniRef50_C9KKX1 Histidinol dehydrogenase n=1 Tax=Mitsuokella multacida DSM 20544
           RepID=C9KKX1_9FIRM
          Length = 447

 Score =  553 bits (1426), Expect = e-156,   Method: Composition-based stats.
 Identities = 156/433 (36%), Positives = 242/433 (55%), Gaps = 9/433 (2%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
             T   ++      + +   +       +    V  I+ +V+  GD A+  Y+   D+  
Sbjct: 17  MLTKASFDEVELSPKIREANKKTFGRDMTAAELVRQIVGDVRREGDAAVIRYTHLIDRVD 76

Query: 63  --VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQV 120
                  V+  E  AA +     + +++  A +N+  +H  QK        + G    Q 
Sbjct: 77  YKPEDFLVTEAEYEAAEKAADPAVVESLRKAAENVRRYHQEQKPNSWMTYREKGSILGQS 136

Query: 121 TRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCG 177
             P+  VG+Y+PGG+A   S+V+M A PAS+AG  ++++  PP    I   +L AA+  G
Sbjct: 137 IIPLDRVGIYVPGGTAAYPSSVIMNAVPASVAGVGEIIMMVPPKNGKINPYVLIAARAAG 196

Query: 178 VQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPS 237
           V+ ++ +GGAQAIAA+AFGTE++P+VDKI GPGN FVT AK++V   +D   IDM AGPS
Sbjct: 197 VKKIYKIGGAQAIAAMAFGTETIPRVDKITGPGNIFVTLAKKEVYGHVD---IDMLAGPS 253

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAET 297
           E+L++AD  A P + A+D+LSQAEH P +  I++T  A++A +VA+  E+QLA LPR E 
Sbjct: 254 EILIVADKTADPVYTAADMLSQAEHDPLASSIVITDDAELAEKVAKEAEKQLAALPRREI 313

Query: 298 ARQALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPE 356
           A+ +++    ++V  D+ Q +  +N   PEH+ + T    +L+  +  AG+VFLG +SPE
Sbjct: 314 AQASIDRNGLIVVADDMMQAMRFANVSAPEHMELLTAQPFQLLPYVRHAGAVFLGAYSPE 373

Query: 357 SAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERL 416
             GDY +G NHVLPT G     S L +  F KR ++   ++   S ++  I  LA  E L
Sbjct: 374 PLGDYFAGPNHVLPTGGTARYYSVLNVETFMKRTSIISYTQPALSDVSEDIIRLAETEGL 433

Query: 417 TAHKNAVTLRVNA 429
            AH NA+ +R   
Sbjct: 434 QAHANAIRIRREQ 446


>UniRef50_P00815 Histidinol dehydrogenase n=17 Tax=cellular organisms
           RepID=HIS2_YEAST
          Length = 799

 Score =  552 bits (1423), Expect = e-156,   Method: Composition-based stats.
 Identities = 194/431 (45%), Positives = 269/431 (62%), Gaps = 10/431 (2%)

Query: 10  NSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVS 69
            +      ++ L RP    SE I   VN I++NV+ +G+ AL EY+ KFD   ++   ++
Sbjct: 363 KASDKVGVQKALSRPIQKTSE-IMHLVNPIIENVRDKGNSALLEYTEKFDGVKLSNPVLN 421

Query: 70  AEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPV-DVETQPGVRCQQVTRPVASVG 128
           A       E L++E+K+A+ ++++N+  FH AQ      +VETQPGV C +  RP+  VG
Sbjct: 422 APFPEEYFEGLTEEMKEALDLSIENVRKFHAAQLPTETLEVETQPGVLCSRFPRPIEKVG 481

Query: 129 LYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP-----PIADEILYAAQLCGVQDVFN 183
           LYIPGG+A L ST LML  PA +A CK++V  SPP      ++ E++Y A+  G   +  
Sbjct: 482 LYIPGGTAILPSTALMLGVPAQVAQCKEIVFASPPRKSDGKVSPEVVYVAEKVGASKIVL 541

Query: 184 VGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDG-AAIDMPAGPSEVLVI 242
            GGAQA+AA+A+GTE++PKVDKI GPGN FVT AK  V        +IDMPAGPSEVLVI
Sbjct: 542 AGGAQAVAAMAYGTETIPKVDKILGPGNQFVTAAKMYVQNDTQALCSIDMPAGPSEVLVI 601

Query: 243 ADSGATPDFVASDLLSQAEHGPDSQVILLTP--AADMARRVAEAVERQLAELPRAETARQ 300
           AD  A  DFVASDLLSQAEHG DSQVIL+    +    + + +AV  Q  +LPR +  R+
Sbjct: 602 ADEDADVDFVASDLLSQAEHGIDSQVILVGVNLSEKKIQEIQDAVHNQALQLPRVDIVRK 661

Query: 301 ALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGD 360
            +  S +++     + +E+SNQY PEHLI+Q  NA + V  + +AGSVF+G ++PES GD
Sbjct: 662 CIAHSTIVLCDGYEEALEMSNQYAPEHLILQIANANDYVKLVDNAGSVFVGAYTPESCGD 721

Query: 361 YASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHK 420
           Y+SGTNH LPTYGY    S    A FQK +T Q ++ EG   +   +  +A  E L  H+
Sbjct: 722 YSSGTNHTLPTYGYARQYSGANTATFQKFITAQNITPEGLENIGRAVMCVAKKEGLDGHR 781

Query: 421 NAVTLRVNALK 431
           NAV +R++ L 
Sbjct: 782 NAVKIRMSKLG 792


>UniRef50_Q2NHT1 HisD n=1 Tax=Methanosphaera stadtmanae DSM 3091 RepID=Q2NHT1_METST
          Length = 407

 Score =  552 bits (1422), Expect = e-155,   Method: Composition-based stats.
 Identities = 164/409 (40%), Positives = 252/409 (61%), Gaps = 8/409 (1%)

Query: 28  ASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQA 87
            S  + + V +I+ NV    D+AL +Y+ KFDK  ++  KV  E I  + E +S +L++A
Sbjct: 2   NSSDVIQPVQEIIANVCENKDKALHDYTLKFDKADISDFKVPVETIKQSVENISPKLRKA 61

Query: 88  MAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLAT 147
           +  A +NI  FH AQ      +  + GV+  Q+ RP++ VG YIPGG A   S++LM   
Sbjct: 62  LEDAAENISKFHKAQIPSDWTMTVKDGVKAGQIIRPLSRVGCYIPGGRAAYPSSILMTVI 121

Query: 148 PASIAGCKKVVLCSPPP----IADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKV 203
           PA IAG ++++ C+PP     ++DEIL AA + GV D++ VGGAQAIAA+A+ T+++P V
Sbjct: 122 PAKIAGVEEIICCTPPDKDGCVSDEILAAAYIAGVTDIYMVGGAQAIAAMAYSTQTIPSV 181

Query: 204 DKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHG 263
           DKI GPGN FV  AK+ V   +D   I+ PAGPSE+L + D  A P+++A++LL+QAEH 
Sbjct: 182 DKIVGPGNIFVATAKKLVYGDVD---IEFPAGPSEMLALVDETANPEYIATELLAQAEHD 238

Query: 264 PDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVEISNQ 322
           P++  IL++ + ++A++  E V   L    R++   ++L     ++V   +   ++ +N 
Sbjct: 239 PNAATILVSTSKEVAQKTVEHVMEYLKTQKRSDIIEESLSKYGHVLVASSMEDAIDFTNA 298

Query: 323 YGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLG 382
           Y PEHL+I T++  + ++SI +AGS+FLG+ +P + GDY SGTNHVLPT G     S L 
Sbjct: 299 YAPEHLVIVTKDHYKTLESINNAGSIFLGNLTPVAGGDYGSGTNHVLPTSGGARMYSGLS 358

Query: 383 LADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNALK 431
              F K+ T+QELS EG   +   +  LA AE L AH  ++  R   ++
Sbjct: 359 AESFLKKPTIQELSPEGVKNIKDMVINLAEAEGLYAHALSIKKRAEDME 407


>UniRef50_Q5FS83 Histidinol dehydrogenase n=3 Tax=Bacteria RepID=HISX_GLUOX
          Length = 430

 Score =  551 bits (1420), Expect = e-155,   Method: Composition-based stats.
 Identities = 177/432 (40%), Positives = 252/432 (58%), Gaps = 9/432 (2%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
              +D ++    +    L+    S   S+   V  IL +V++RGDEAL +Y+A+FD+ T+
Sbjct: 1   MKRLDTSAAGFSEDFATLLAARGSDERSVAEPVRAILADVRSRGDEALCDYTARFDRLTL 60

Query: 64  --TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVT 121
               L++SAEEIA+ + R+  +L  A+  A + IETFH AQ    +D   + G+R     
Sbjct: 61  PAEKLRISAEEIASEAARVPADLMDALRTAARRIETFHAAQMPKDLDFTDEDGIRLGMRW 120

Query: 122 RPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCGV 178
            P+ +VGLY+PGG A   S+VLM A PA +AG K++ +C P P   +   +L AAQLCGV
Sbjct: 121 TPLDAVGLYVPGGKAAYPSSVLMNALPARVAGVKRLAMCVPSPDGVLNPLVLAAAQLCGV 180

Query: 179 QDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSE 238
           ++++ +GGAQA+ A+AFGT+ +  VD+I GPGNA+V EAKRQV   +    ID  AGPSE
Sbjct: 181 EEIYRIGGAQAVGAMAFGTDLIAPVDRIVGPGNAYVAEAKRQVFGHV---GIDSIAGPSE 237

Query: 239 VLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETA 298
           V+V+AD    P  VA DLL+QAEH   +Q IL+T  A  A R AEAV ++L  LPR   A
Sbjct: 238 VVVVADGQNDPRLVALDLLAQAEHDEQAQAILITTDAAFAERAAEAVRKELETLPRTAIA 297

Query: 299 RQAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPES 357
            ++  +   +IV + L +  EI N   PEHL +     R+    I  AG++F+G + PE+
Sbjct: 298 SKSWEDHGAIIVVRSLEEAAEIVNALAPEHLEVMLDAPRDFSAMIRHAGAIFMGRYCPEA 357

Query: 358 AGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLT 417
            GDY  G NHVLPT       S L + DF KR T  E  + G   +      LA AE L 
Sbjct: 358 VGDYVGGPNHVLPTSRTARFASGLSVFDFIKRTTTIEADEAGLRRIGPAGVALAKAEGLD 417

Query: 418 AHKNAVTLRVNA 429
           AH  ++++R+  
Sbjct: 418 AHALSLSVRLEK 429


>UniRef50_Q1Q2D0 Histidinol dehydrogenase n=1 Tax=Candidatus Kuenenia
           stuttgartiensis RepID=Q1Q2D0_9BACT
          Length = 439

 Score =  550 bits (1419), Expect = e-155,   Method: Composition-based stats.
 Identities = 167/439 (38%), Positives = 263/439 (59%), Gaps = 13/439 (2%)

Query: 4   NTIIDWNSCTAEQQRQLLMRP--AISASESITRTVNDILDNVKARGDEALREYSAKFDKT 61
             I+    C A  + + + +    +++S  I  TV  I+ +VK  GD+A+  Y  +FDK 
Sbjct: 1   MRILKTWECDASLEIEKIKQGLDPLNSSSDIRTTVLKIIQDVKKNGDKAIAAYGKRFDKA 60

Query: 62  --TVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQ 119
             +    +V  EEI  A + ++ +  +A+ +A+KNI+T+    ++  V      GV    
Sbjct: 61  PLSPEQFRVKEEEIEDAYKYVTGKFIKAIRLAIKNIQTYQNHIRIQNVKPLRSKGVILDT 120

Query: 120 VTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQL 175
           +  P+ S G+Y+PGG+A   STVLM A PA +AG +K+V+ SPP     I  E L AA+ 
Sbjct: 121 IYTPIDSAGIYVPGGAASYPSTVLMNAIPAQVAGVEKIVMVSPPKEDGNIPPERLVAAKE 180

Query: 176 CGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAG 235
            GV +++ +GG QAIAALAFGT+++P VDKI GPGN FVT AK+++      A IDM AG
Sbjct: 181 AGVSEIYKIGGVQAIAALAFGTKTIPSVDKIVGPGNVFVTLAKKEIFGY---AGIDMLAG 237

Query: 236 PSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRA 295
           PSEVL+IAD+ A P ++ASDLLSQAEH P    +L+T +  +A++V   +  Q+  L R+
Sbjct: 238 PSEVLIIADNHANPSYIASDLLSQAEHTPG-ISLLVTSSKLLAKQVLAEITLQIKTLSRS 296

Query: 296 ETARQAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWS 354
               + L     + +TK++ +C+ +SN   PEHL I T+N + ++  I  AG+VF+GD++
Sbjct: 297 AGTNECLCKYGVIFITKNMNECIALSNAIAPEHLQIMTQNPKAVLSGIKHAGAVFVGDYT 356

Query: 355 PESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAE 414
           P + GDY +G +HVLPT G     S L + DF KR +V   S+    ++   +  ++A+E
Sbjct: 357 PVALGDYIAGPSHVLPTGGTARFSSGLSVNDFIKRTSVITYSQSALRSVQQDVSEISASE 416

Query: 415 RLTAHKNAVTLRVNALKEQ 433
            L AH  +V +R+++ +++
Sbjct: 417 GLDAHAKSVKIRLDSGRKK 435


>UniRef50_C0QG33 Histidinol dehydrogenase n=4 Tax=Deltaproteobacteria
           RepID=C0QG33_DESAH
          Length = 432

 Score =  550 bits (1418), Expect = e-155,   Method: Composition-based stats.
 Identities = 177/435 (40%), Positives = 249/435 (57%), Gaps = 13/435 (2%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFD--KT 61
             I  + S   EQ+    ++  +  +    R V   +++V+ RGD+AL EY+ +FD  + 
Sbjct: 1   MKIYTYPSPEGEQRICDTLKRGLGFTPENQRAVEAYIEDVRTRGDQALVEYTNQFDSSQV 60

Query: 62  TVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVT 121
           T   LKVS +EI  A   +  +  +A+  AV  + TFH+ Q+        + GV   Q+ 
Sbjct: 61  TRDTLKVSQQEIEEAKTLVDSDFSRALDRAVDQLGTFHSRQRQNSWIDTPRNGVMVGQMV 120

Query: 122 RPVASVGLYIPG---GSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQ 174
            PV + G+Y PG   G  PL S+VLM   PA +AG K   L +PP     I   +L AA 
Sbjct: 121 NPVDAAGIYAPGAKGGKTPLVSSVLMGGIPARVAGVKSCCLMTPPMENGKINPYMLVAAD 180

Query: 175 LCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPA 234
             G+  +F  G A AIAALAFGTESVPKVD I GPGN FVT AK+ VS  +    IDM A
Sbjct: 181 RVGINAIFKAGSAWAIAALAFGTESVPKVDVIVGPGNIFVTLAKKIVSGIV---GIDMIA 237

Query: 235 GPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPR 294
           GPSE+L+IAD GA PD +A+DLLSQAEH P +  IL+T + +MA R   A+E Q+  L R
Sbjct: 238 GPSEILIIADKGANPDHIAADLLSQAEHDPMASAILVTDSMEMATRTKAALEIQVKALGR 297

Query: 295 AETARQALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDW 353
            + A+++++    ++   D+   + ++N+  PEHL +   N  + V  I +AG+VFLG +
Sbjct: 298 RQIAQRSIDDFGAIMKVPDIDTAIALANRLAPEHLELIVDNPFDQVGKIKNAGAVFLGPY 357

Query: 354 SPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAA 413
           +PE  GDY +G NHVLPT G     S+LG+ +F KR ++   SKE F   A  +  LA  
Sbjct: 358 TPEPMGDYIAGPNHVLPTAGTARFSSALGVDNFTKRTSLINYSKEAFDREAQDVMVLANI 417

Query: 414 ERLTAHKNAVTLRVN 428
           E L AH N+V +R  
Sbjct: 418 EGLGAHANSVRIRTK 432


>UniRef50_B2KCM4 Histidinol dehydrogenase n=1 Tax=Elusimicrobium minutum Pei191
           RepID=B2KCM4_ELUMP
          Length = 429

 Score =  547 bits (1410), Expect = e-154,   Method: Composition-based stats.
 Identities = 198/433 (45%), Positives = 280/433 (64%), Gaps = 9/433 (2%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
             I ++ + T ++ + L  R  +   E + + V +    V  RGD+A++E +A FD  T+
Sbjct: 1   MKIYNYATLTKKEIKALSERSYL-MPEKLKQAVWETGLQVMKRGDKAIKELTAAFDGVTL 59

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQ-KLPPVDVETQPGVRCQQVTR 122
           ++LKVS +E   A + +S+ELK A+  A +NI  FH +Q K     +ET  G+ C +  +
Sbjct: 60  SSLKVSVKEFKQAEKLVSNELKDAIKTASENIAKFHKSQLKTKEPVIETSKGIECWREFK 119

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGV 178
            + + GLY+PGGSAPLFSTVLMLA PA IAGCKKV +C+PP     IA EIL+AA+  GV
Sbjct: 120 ALGTAGLYVPGGSAPLFSTVLMLAVPAKIAGCKKVYICTPPCKNGLIAPEILFAAKTAGV 179

Query: 179 QDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSE 238
            +V+ +GGAQA+ A+A+GT++VPK DKIFGPGN +VT+AK +VS      AIDMPAGPSE
Sbjct: 180 DEVYKIGGAQAVFAMAYGTQTVPKADKIFGPGNQYVTQAKMEVSS---FTAIDMPAGPSE 236

Query: 239 VLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETA 298
           VL+IA+      + A+D+LSQAEHGPDSQ +L   + +  + +   V+ QL +L R   A
Sbjct: 237 VLIIAEESTNASYAAADILSQAEHGPDSQAVLACSSKNKIKEIIAEVDAQLKKLGRKSIA 296

Query: 299 RQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESA 358
            +AL  S ++ T++  + VE SN Y PEHLI+  ++ ++ + S+ +AGSVF G  + ES 
Sbjct: 297 AKALGKSFIMQTRNTKESVEFSNIYAPEHLILNFKDWKKYLTSVQNAGSVFCGTLATESF 356

Query: 359 GDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTA 418
           GDYASGTNH LPT G+  +   L    F K +T Q +S +G   L  T+E +A AE LTA
Sbjct: 357 GDYASGTNHTLPTSGFAKSFGGLNTQSFGKWITYQTVSAQGLRGLGKTVEIMAEAEGLTA 416

Query: 419 HKNAVTLRVNALK 431
           HKNAVT+R+   K
Sbjct: 417 HKNAVTIRIENEK 429


>UniRef50_Q2PPB3 Histidine biosynthesis trifunctional protein n=12 Tax=Phaeosphaeria
           RepID=Q2PPB3_PHANO
          Length = 881

 Score =  547 bits (1409), Expect = e-154,   Method: Composition-based stats.
 Identities = 199/432 (46%), Positives = 265/432 (61%), Gaps = 8/432 (1%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
                    T+E     L RP+  ++  I      I+D VK RGD AL EY+ KF+K T 
Sbjct: 447 MKRYVTAQETSETIAAALQRPSQKSTGKIIGICRPIIDAVKTRGDAALLEYTHKFEKATS 506

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKL-PPVDVETQPGVRCQQVTR 122
               V          +L+ E  +A+ V+ +NI  FH AQ+   P+ VET PGV C +  R
Sbjct: 507 LTSPVLRAPFPPELMQLAPETAKAIDVSFENIRKFHAAQREEKPLVVETMPGVVCSRFAR 566

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGV 178
           P+  VGLY+PGG+A L ST LML  PA +AGCKK+VL +PP     +  E++YAA   G 
Sbjct: 567 PIERVGLYVPGGTAVLPSTALMLGVPAMVAGCKKIVLATPPRSNGKVTPEVVYAAHKVGA 626

Query: 179 QDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLD-GAAIDMPAGPS 237
           + +   GGAQA+AA+A+GTESV KVDKI GPGN FVT AK  VS   + G +IDMPAGPS
Sbjct: 627 EMIVLAGGAQAVAAMAYGTESVSKVDKILGPGNQFVTAAKMHVSNDTNAGVSIDMPAGPS 686

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTP--AADMARRVAEAVERQLAELPRA 295
           E+LVIAD+ A P FVASDLLSQAEHG DSQVIL+           + + + +Q   LPR 
Sbjct: 687 ELLVIADASANPAFVASDLLSQAEHGVDSQVILIAVGLNEAQLTAIEDELHKQANALPRV 746

Query: 296 ETARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSP 355
           +  R A+  S  +    + + +E+SNQY PEHLI+Q  NA ++V+ + +AGSVF+G+W+P
Sbjct: 747 DIVRGAIEHSLTLAASTIEEALELSNQYAPEHLILQVANADKVVELVENAGSVFIGEWTP 806

Query: 356 ESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAER 415
           ES GDY++G NH LPTYGY    S + LA + K +T   L+KEG   +   +  LA  E 
Sbjct: 807 ESVGDYSAGVNHSLPTYGYAKQYSGVNLASYVKHITSAHLTKEGLQNVGPAVMELARVEE 866

Query: 416 LTAHKNAVTLRV 427
           L AH+ AV+LR+
Sbjct: 867 LEAHRRAVSLRL 878


>UniRef50_B3WED5 Histidinol dehydrogenase n=21 Tax=Bacilli RepID=B3WED5_LACCB
          Length = 430

 Score =  544 bits (1402), Expect = e-153,   Method: Composition-based stats.
 Identities = 178/433 (41%), Positives = 249/433 (57%), Gaps = 8/433 (1%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
             I+     +  +Q+  + R A++ +  +   V  I+  V+A GD ALR YS K D  TV
Sbjct: 1   MKILTGT-LSQLKQQVDIRRTAVAQNTDVQTIVQAIIAKVRAEGDSALRTYSNKLDHVTV 59

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRP 123
              +V    I AA  +L  +L +A+ +A  NI ++H  +           G+   Q   P
Sbjct: 60  NDFQVDQALIDAAPAQLPAKLLKALQLAKANITSYHQNEIERGFVDTPNSGIIRGQKITP 119

Query: 124 VASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP---PIADEILYAAQLCGVQD 180
           +A+VGLY+PGG+A   ST+LM A PA +AG KK+V+ +PP    +   +L AA L GV  
Sbjct: 120 LAAVGLYVPGGTAAYPSTILMTAIPAKLAGVKKIVMVTPPQPDGLNPVVLAAANLAGVDA 179

Query: 181 VFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVL 240
           ++ VGGAQAIAALA+GTES+P+VDKI GPGN +V EAK+QV   +   AIDM AGPSE+ 
Sbjct: 180 IYQVGGAQAIAALAYGTESIPRVDKIMGPGNRYVAEAKKQVFGNV---AIDMIAGPSEIG 236

Query: 241 VIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQ 300
           +IAD  A P  +A+DLLSQAEH P+++ +++T +  +A  V+E ++ QL  LPR   AR 
Sbjct: 237 IIADESADPIRLAADLLSQAEHDPNARAMMVTTSEKLASAVSEQIDIQLPTLPRESIARA 296

Query: 301 ALNA-SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAG 359
           A+     + +   +     + N   PEHL +Q  +    +  I +AGSVFLG  + E  G
Sbjct: 297 AIENQGFIAIVATINDAFSLMNTIAPEHLEVQLPDPITYLAQIQNAGSVFLGQNAAEPVG 356

Query: 360 DYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAH 419
           DY +G NHVLPT G     S LG+ DF KR    + S E  ++ A  I TLA AE L  H
Sbjct: 357 DYVAGPNHVLPTAGSARFFSPLGVYDFVKRTQFIQYSSEALASQADAIVTLAQAEGLDGH 416

Query: 420 KNAVTLRVNALKE 432
             A+  RV A KE
Sbjct: 417 AEAIIKRVPAAKE 429


>UniRef50_C4V2I6 Histidinol dehydrogenase n=1 Tax=Selenomonas flueggei ATCC 43531
           RepID=C4V2I6_9FIRM
          Length = 448

 Score =  544 bits (1402), Expect = e-153,   Method: Composition-based stats.
 Identities = 165/434 (38%), Positives = 250/434 (57%), Gaps = 11/434 (2%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
                D     A  + +         + S    V+ I+ +V++ GD+AL  Y+   D   
Sbjct: 19  MKKAFDEIELGASMRAKNQEIFGEDLTAS--ELVHHIVRDVRSGGDQALLRYTKLLDGLD 76

Query: 63  VTA--LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQV 120
           +++  + VS  E+ AA+++    +  ++  A KNI  FH  QK          G    Q 
Sbjct: 77  LSSTDIMVSESELQAAADQADAAVLASLERAAKNIFAFHEEQKPKSWMTYRAHGSILGQE 136

Query: 121 TRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCG 177
             P++ VG+Y+PGG+A   S+VLM A PA +AG   +++  P     +   +L AA + G
Sbjct: 137 VIPLSRVGIYVPGGTAAYPSSVLMNAIPAIVAGVDDIIMSVPTKGGVLNPYVLAAAHMLG 196

Query: 178 VQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPS 237
           ++ +F VGGAQAIAA+A+GTES+P+VDKI GPGN FVT AK++V   +D   IDM AGPS
Sbjct: 197 IKKIFRVGGAQAIAAMAYGTESIPRVDKITGPGNLFVTLAKKEVYGYVD---IDMLAGPS 253

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAET 297
           E+L++AD  A+P ++A+D+LSQAEH P +  IL+T +AD+A  V   ++ QL  LPR ET
Sbjct: 254 EILILADEEASPKYIAADMLSQAEHDPLASSILITDSADLASNVRCEIQDQLQSLPRMET 313

Query: 298 ARQALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPE 356
           A  +L    R+IVT+++ Q V ++N  GPEH+ +  ++A  L+  I  AG+VF+G +SPE
Sbjct: 314 ASASLERNGRIIVTENIQQSVHLANYSGPEHIELLVKDAFHLLPEIRCAGAVFVGSYSPE 373

Query: 357 SAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERL 416
             GDY +G NHVLPT G     S L +  F KR ++   +++    ++  I  LA  E L
Sbjct: 374 PLGDYFAGPNHVLPTGGTARFYSVLNVETFMKRTSIISYTRKALDEVSDDIIRLAETEGL 433

Query: 417 TAHKNAVTLRVNAL 430
            AH  A+  R + +
Sbjct: 434 EAHARAIRTRRDNI 447


>UniRef50_D2RJQ0 Histidinol dehydrogenase n=7 Tax=Firmicutes RepID=D2RJQ0_ACIFE
          Length = 448

 Score =  543 bits (1401), Expect = e-153,   Method: Composition-based stats.
 Identities = 174/447 (38%), Positives = 255/447 (57%), Gaps = 27/447 (6%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISA---SESITRTVND--------------ILDNVKAR 46
             + D    TAE+  +LL + +      S  +   V                I+++++ +
Sbjct: 1   MKVYDERKSTAEEISRLLEKKSFDEVKLSPKVAAAVEKMFGRPLTAAEEVDIIVNDIRNK 60

Query: 47  GDEALREYSAKFDKTTVTA--LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKL 104
           GDEAL EY+ K D   +    ++V+ EE A A + + ++   A+  A+ N+  FH  Q  
Sbjct: 61  GDEALFEYTKKLDGADLRPATIRVTEEEFAEAEKAVDEKTMGAIRRAIANVRKFHEEQLP 120

Query: 105 PPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSP-- 162
                    G    Q   PV SVG+Y+PGG+A   S+V+M A PA +AG  ++ + +P  
Sbjct: 121 KTWLTPRAYGSFLGQKMTPVDSVGIYVPGGTAAYPSSVIMNAVPAKVAGVPRIAMAAPAG 180

Query: 163 --PPIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQ 220
               +   +L  A+  G+ +++ +GGAQAIAALAFGTE++PKV+KI GPGN FVT AK+ 
Sbjct: 181 RDGKMNPYVLATAKEIGITEIYKMGGAQAIAALAFGTETIPKVEKITGPGNIFVTLAKKA 240

Query: 221 VSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARR 280
           V   +D   IDM AGPSE+L++AD  A   ++A+DLLSQAEH P +  IL+T   D+A +
Sbjct: 241 VYGHVD---IDMLAGPSEILIVADKTADYQYLAADLLSQAEHDPLACAILITDDEDLAGK 297

Query: 281 VAEAVERQLAELPRAETARQALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELV 339
           VAE VE QL +LPR E A Q+L    ++I+ KD+   VE++N   PEH+ I TR    LV
Sbjct: 298 VAEEVEVQLQKLPRKEIAAQSLAVQGKIILAKDMDTVVEMANISAPEHMEINTREPFALV 357

Query: 340 DSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEG 399
             I +AG++FLG +SPE  GDY +G NH+LPT G     S L +  F K+ ++   +KE 
Sbjct: 358 PRIRNAGAIFLGAYSPEPLGDYYAGPNHILPTGGTARFYSVLNVETFMKKTSIISYTKEA 417

Query: 400 FSALASTIETLAAAERLTAHKNAVTLR 426
            +  A  I  +A AE L AH NA+ +R
Sbjct: 418 LAEAADDIIAMAEAEGLQAHANAIRIR 444


>UniRef50_C1PFR7 Histidinol dehydrogenase n=1 Tax=Bacillus coagulans 36D1
           RepID=C1PFR7_BACCO
          Length = 427

 Score =  543 bits (1401), Expect = e-153,   Method: Composition-based stats.
 Identities = 152/429 (35%), Positives = 234/429 (54%), Gaps = 8/429 (1%)

Query: 5   TIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVT 64
            I ++      +        +    E + RT  ++L++++  GD A+++Y+AKFD     
Sbjct: 1   MIREYTKEAFAETFLQSKNKSGVHDEGVLRTAKEVLEDIRLNGDAAVKKYTAKFDGEVPE 60

Query: 65  ALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPV 124
           + +V  EE   A   +  ++  A+  A +NI  FH  Q      +E    +   Q+ RPV
Sbjct: 61  SWEVLPEERKQAWHEVPQDVISALQKAAENIRRFHAKQLQNSRIMEMNENIISGQLFRPV 120

Query: 125 ASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSP----PPIADEILYAAQLCGVQD 180
              G+Y+PGG+A   S+VLM A PA +AG ++V++ +P      IA  +  AA + GV  
Sbjct: 121 EKAGIYVPGGTACYPSSVLMNAIPAVLAGVEEVIMATPARNGTKIAPVLSVAADIAGVGT 180

Query: 181 VFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVL 240
           ++ +GG QAI ALA+GTE++PKVDKI GPGNA+V  AK  V   +    IDM AGPSEV 
Sbjct: 181 IYKLGGIQAIGALAYGTETIPKVDKIVGPGNAYVAAAKSLVYGTV---GIDMIAGPSEVA 237

Query: 241 VIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQ 300
           +IAD  A P ++A+DL++QAEH   ++  L T +  +      A+E+QL  LPR +    
Sbjct: 238 IIADENANPVYIAADLIAQAEHDERARTFLFTTSQKLINETKSALEKQLVVLPRRDIGEV 297

Query: 301 ALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAG 359
           ++   S  ++ + + +   +SN+  PEHL IQ  N    +  + +AGSVFLG+ +PE+ G
Sbjct: 298 SIKMQSAAVLVESIDEAFALSNRLAPEHLEIQVENPLLQLSKVKNAGSVFLGENTPEAIG 357

Query: 360 DYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAH 419
           DY  G NH+LPT G     S L + DF K++T     ++     A  +  +A  E+L  H
Sbjct: 358 DYYGGPNHILPTSGTARFSSGLSVDDFYKKITYLYYGEKALQQAAPDVMAIATEEQLAGH 417

Query: 420 KNAVTLRVN 428
             AV  RV 
Sbjct: 418 ARAVQKRVK 426


>UniRef50_B2A652 Histidinol dehydrogenase n=1 Tax=Natranaerobius thermophilus
           JW/NM-WN-LF RepID=B2A652_NATTJ
          Length = 428

 Score =  543 bits (1401), Expect = e-153,   Method: Composition-based stats.
 Identities = 165/421 (39%), Positives = 245/421 (58%), Gaps = 11/421 (2%)

Query: 16  QQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAA 75
           ++ +L  + A         TV  I+D V+  GD+AL E +   D  +++ L+VS E +  
Sbjct: 5   KEAKLASQKAKFEDVETRNTVTKIIDQVRTNGDKALFELTQSLDNCSLSKLEVSQEYMKQ 64

Query: 76  ASERLSDELKQAMAVAVKNIETFHTAQK--LPPVDVETQPGVRCQQVTRPVASVGLYIPG 133
             + L+D+ K+A+  A   IE F + Q      ++ E  PGV+     +P++S G Y+P 
Sbjct: 65  CYDNLTDKTKEALNFAKDQIEFFASQQLAGFKEIECENIPGVKLGYKIKPISSCGCYVPA 124

Query: 134 GSAPLFSTVLMLATPASIAGCKKVVLCSPP-----PIADEILYAAQLCGVQDVFNVGGAQ 188
           G  PL S+ LM   PA +AG +++V  +PP      I  E+L A  L GV +V+ VGGA 
Sbjct: 125 GRYPLPSSALMSIVPARVAGVERIVAIAPPVRKYGGIHPELLAAMYLAGVDEVYIVGGAH 184

Query: 189 AIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGAT 248
            IAALA GTE++ KVD I GPGN +VTEAKRQ++  +    ID  AGPSEVL+IAD+ A+
Sbjct: 185 GIAALALGTETISKVDFIVGPGNKYVTEAKRQLNGIV---GIDQLAGPSEVLIIADNTAS 241

Query: 249 PDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRL 307
              VA+DLL+QAEH PD+  +L+T +  +A+ V + + RQL EL   ETA ++  +   +
Sbjct: 242 STNVAADLLAQAEHDPDAVCVLVTTSEQLAKEVNQEIHRQLDELLTWETAAKSWEDYGEI 301

Query: 308 IVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNH 367
           I+  +L Q +EIS+Q  PEHL + T N   +++ +   GS+F+G+W+  + GDY SGTNH
Sbjct: 302 ILVDNLDQAIEISDQMAPEHLQLMTDNNSNIMEMVNHYGSLFVGEWASVAFGDYVSGTNH 361

Query: 368 VLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRV 427
           +LPT       S L +  F K  + Q L++ G   L+     LA  E L AHK +  LR 
Sbjct: 362 ILPTGNSARFSSGLSVGKFLKMSSYQVLTETGAHELSDKCMHLAELEGLEAHKKSAELRA 421

Query: 428 N 428
           +
Sbjct: 422 D 422


>UniRef50_C3XDE7 Histidinol dehydrogenase n=1 Tax=Helicobacter bilis ATCC 43879
           RepID=C3XDE7_9HELI
          Length = 452

 Score =  542 bits (1398), Expect = e-153,   Method: Composition-based stats.
 Identities = 156/455 (34%), Positives = 242/455 (53%), Gaps = 28/455 (6%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              I++ +    E +   L+  A +  +SI   V   L ++K RG++AL +   K+D   
Sbjct: 1   MIKILNIHDKDFETEFNTLLARANTDMDSIIPEVLKTLQDIKQRGEDALLDIVRKYDSWN 60

Query: 63  V---TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQ 119
                 LK++ E+   A + L  + K A+ +A   I TFH            +      Q
Sbjct: 61  PQTFNDLKIAEEDTFNAYKNLDSKTKDALQIAHDRIYTFHAKNAPKGFIYHDEYANMLGQ 120

Query: 120 VTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLC 176
              P+   G+YIPGG A   S++LM A PA +AG K++++ SP P   I + +L A  LC
Sbjct: 121 NIMPIQRAGIYIPGGKAFYPSSLLMNAIPAKVAGVKEIIMASPTPNNHINELVLAAMYLC 180

Query: 177 GVQDVFNVGGAQAIAALAFG--------------TES----VPKVDKIFGPGNAFVTEAK 218
           G+++ + +GG  AI   A+G              T++      KVD I GPGN +V  AK
Sbjct: 181 GIKEGYKIGGIGAIGMFAYGFGETKWSKDSLFSHTKTTQKGFKKVDVITGPGNIYVATAK 240

Query: 219 RQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMA 278
           + V   ++   IDM AGPSE+ +IADS A  D++A D+LSQAEH   +  IL+T   D+A
Sbjct: 241 KLVFGEVN---IDMIAGPSEIGIIADSHANSDYLAIDMLSQAEHDSMASAILITDNKDLA 297

Query: 279 RRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARE 337
           + VA+ ++ +L  L R + A++++     +I+ ++L Q   + N   PEHL I T+    
Sbjct: 298 KEVAQKIDTKLTHLMRKDIAQKSIQERGAIIIVENLKQAAMLMNAIAPEHLEIVTQEPFS 357

Query: 338 LVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSK 397
           L+  I +AG+VFLG ++PE+ GDY +G NH LPT G     S LG+  F  R ++   SK
Sbjct: 358 LLGEIKAAGAVFLGHYTPEAIGDYLAGPNHTLPTGGSARFFSPLGVEHFCTRSSLISFSK 417

Query: 398 EGFSALASTIETLAAAERLTAHKNAVTLRVNALKE 432
           +G   LA+    LA  E L AHK +V  R++++K+
Sbjct: 418 QGIKNLANPCAILAETEGLEAHKLSVISRLDSMKD 452


>UniRef50_Q46WL2 Histidinol dehydrogenase 1 n=202 Tax=Bacteria RepID=HISX1_RALEJ
          Length = 445

 Score =  541 bits (1395), Expect = e-152,   Method: Composition-based stats.
 Identities = 172/439 (39%), Positives = 244/439 (55%), Gaps = 14/439 (3%)

Query: 2   SFNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKT 61
                +D +     Q  + ++       E+I R V  IL +VK RGD A+ EY+ +FD+ 
Sbjct: 9   VSIRRLDSSDPRFAQALREVLAFEAGEDEAIDRAVAQILADVKDRGDAAVLEYTQRFDRV 68

Query: 62  T---VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQK----LPPVDVETQPG 114
               + AL++S  E+ AA E L  + + A+  A   +  +H  QK        +     G
Sbjct: 69  EAASMGALEISQSELEAALEDLEPKRRAALEAAAARVRAYHEKQKIECGSHSWEYTEADG 128

Query: 115 VRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLC--SPPPI-ADEILY 171
               Q   P+  VG+Y+PGG A   S+VLM A PA +AG K++++   +P  +  + +L 
Sbjct: 129 TMLGQKVTPLDRVGIYVPGGKAAYPSSVLMNAIPARVAGVKEIIMVVPTPGGVRNELVLA 188

Query: 172 AAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAID 231
           AAQ+ GV  VF +GGAQA+ ALA+GT ++P+VDKI GPGNA+V  AKR+V   +    ID
Sbjct: 189 AAQIAGVDRVFTIGGAQAVGALAYGTATLPQVDKIVGPGNAYVAAAKRRVFGTV---GID 245

Query: 232 MPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAE 291
           M AGPSE+LVI D    PD+VA DL SQAEH   +Q ILL P AD   +V  +++RQL  
Sbjct: 246 MIAGPSEILVICDGTTDPDWVAMDLFSQAEHDELAQSILLCPDADYIAQVEASIQRQLDS 305

Query: 292 LPRAETARQALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFL 350
           +PR E    +++    LI  +D+ +  EI+N   PEHL I   N R+  + I  AG++FL
Sbjct: 306 MPRREVIAASISGRGALIKVRDMEEACEIANAIAPEHLEISAENPRQWSEKIRHAGAIFL 365

Query: 351 GDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETL 410
           G ++ ES GDY +G NHVLPT       S LG+ DFQKR ++ E+S+ G   L      L
Sbjct: 366 GRYTSESLGDYCAGPNHVLPTSRTARFSSPLGVYDFQKRSSLIEVSEGGAQMLGQIAAEL 425

Query: 411 AAAERLTAHKNAVTLRVNA 429
           A  E L AH  +   R   
Sbjct: 426 AYGEGLQAHARSAEYRFKR 444


>UniRef50_Q3J079 Histidinol dehydrogenase 1 n=26 Tax=Proteobacteria
           RepID=HISX1_RHOS4
          Length = 434

 Score =  540 bits (1393), Expect = e-152,   Method: Composition-based stats.
 Identities = 171/436 (39%), Positives = 242/436 (55%), Gaps = 9/436 (2%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
               +D      E     L+      S  +   V  I+ +V+ARGD A+ E +A+FD+  
Sbjct: 1   MPQFLDTRRPGFEADFTALLGMKREDSPDVDAVVAGIIADVRARGDAAVIELTARFDRLE 60

Query: 63  VTALKV--SAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQV 120
           +T  ++  S  EI A    +S E + A+ +A + I  +H  Q           G      
Sbjct: 61  LTPERLAFSEAEIEAEIATVSAEDRAALELAAERIRAYHARQMPENARWTDAAGAELGWR 120

Query: 121 TRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCG 177
             P+AS GLY+PGG A   S+VLM A PA +AG +++V+  P P   +   +L AA+L G
Sbjct: 121 WGPIASAGLYVPGGLASYPSSVLMNAIPARVAGVERLVVACPTPGGVVNPLVLLAARLAG 180

Query: 178 VQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPS 237
           V  V+ +GGAQA+AALA+GTE++  VDKI GPGNA+V  AKR+V  R+    IDM AGPS
Sbjct: 181 VDAVYRIGGAQAVAALAYGTETIRPVDKITGPGNAYVAAAKRRVFGRV---GIDMIAGPS 237

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAET 297
           E+LVIA+    PD++A DLLSQAEH   +Q IL+TP   + R V +AVE +L  L R   
Sbjct: 238 EILVIAEGAVDPDWIALDLLSQAEHDESAQSILVTPDEALGRAVVQAVEARLETLERRAI 297

Query: 298 ARQAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPE 356
           A  +  +   +IVT+DL +   +S++  PEHL +   +   L   I  AG++FLG W+PE
Sbjct: 298 AGASWRDYGAVIVTRDLEEAAALSDRVAPEHLELCVADPEALAARIRHAGAIFLGGWTPE 357

Query: 357 SAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERL 416
           + GDY  G NHVLPT       S L + DF KR T+  ++     A+    E LA +E L
Sbjct: 358 AIGDYVGGPNHVLPTARSARFSSGLSVMDFLKRTTLARMTPAALRAVGPAAERLAISESL 417

Query: 417 TAHKNAVTLRVNALKE 432
            AH  +V  R++ L E
Sbjct: 418 EAHGLSVRARLDRLNE 433


>UniRef50_B3TCH3 Putative Histidinol dehydrogenase n=1 Tax=uncultured marine
           microorganism HF4000_APKG10K24 RepID=B3TCH3_9ZZZZ
          Length = 444

 Score =  540 bits (1391), Expect = e-152,   Method: Composition-based stats.
 Identities = 159/436 (36%), Positives = 244/436 (55%), Gaps = 13/436 (2%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
              +D +        +         S    ++V  +L +V+  GD A+R YS   D   +
Sbjct: 15  IDPLDLSDLPKAVLDRTHQAFGEDVSPE--QSVLKMLQDVRQDGDAAVRRYSKLLDGVEL 72

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRP 123
           ++ KV  E++A A+  +S EL++++ +A + I  FH A        E        Q+ RP
Sbjct: 73  SSFKVEKEQLAQAAASVSTELRESLELAAERIRQFHQAVMPKDWLDEEGG---LGQLVRP 129

Query: 124 VASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQ 179
           +  VGLY PGG+A   STVLM A PA +AG  +V+LC+P      +   +L AA++ GV 
Sbjct: 130 LERVGLYAPGGTAAYPSTVLMTAIPARVAGVNEVILCTPARPGEALNPAVLVAAEISGVD 189

Query: 180 DVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEV 239
            V+ +GG  AI A+A+GT+SVPKVDKI GPGN FV  AK+ V  ++D   ID   GP+E 
Sbjct: 190 TVYQIGGVPAIGAMAYGTDSVPKVDKICGPGNVFVAYAKKLVQGQVD---IDGVFGPTET 246

Query: 240 LVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETAR 299
           +VIAD  A P F A+DL+ QAEH P +  IL+T + D+  RV   ++ QL    R + AR
Sbjct: 247 VVIADESADPGFCAADLIGQAEHDPLATAILITDSQDLIDRVERELDEQLNIQLRGDLAR 306

Query: 300 QALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESA 358
           QAL    R+++ + +A+ VE++++  PEH+ +  ++  +   ++  AG +FLG++SPE  
Sbjct: 307 QALERQGRIVLVESVAEAVELADRIAPEHMCLMVQDPWKWAGTVKHAGGLFLGEYSPEVM 366

Query: 359 GDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTA 418
           GDY +G +HV+PT G     S+L +  F + M V  LS + F  L      +A AE L  
Sbjct: 367 GDYVAGPSHVMPTGGTARFSSALSVHQFLRTMPVVSLSADDFQKLGPAAIEIAKAEGLDG 426

Query: 419 HKNAVTLRVNALKEQA 434
           H  AV +R++ L++  
Sbjct: 427 HATAVRMRLDKLQKLG 442


>UniRef50_Q3AR25 Histidinol dehydrogenase n=13 Tax=Bacteria RepID=HISX_CHLCH
          Length = 428

 Score =  540 bits (1391), Expect = e-152,   Method: Composition-based stats.
 Identities = 150/433 (34%), Positives = 230/433 (53%), Gaps = 10/433 (2%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              +  +    +  Q +L+    +S  E+  + V++IL  V+ +GD A+  Y+ +F    
Sbjct: 1   MLPLYRFPQEASALQERLV--RHVSFDEAAHKAVDEILAKVRQQGDRAVLNYTEQFQGVR 58

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
           +T+++V  E I  A       L   +  A  NI  FH  +       E + GV   Q  R
Sbjct: 59  LTSMQVDEEAIEMAYRHADPSLIATLHEAYANIVRFHEHEVERSFFYEAEGGVLLGQRVR 118

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSP----PPIADEILYAAQLCGV 178
           P+    LY+PGG A   S++LM A PA +AG  ++ + +P      +   IL AA++ G+
Sbjct: 119 PMERAMLYVPGGKAAYPSSLLMNAAPAKVAGVCEIAVTTPCDATGVVNPTILAAAKVAGI 178

Query: 179 QDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSE 238
             ++ +GGAQA+AA A+GTES+PKVD I GPGN +V  AK+QV   +   AID  AGPSE
Sbjct: 179 SSIYKIGGAQAVAAFAYGTESIPKVDIITGPGNKYVALAKKQVFGHV---AIDSIAGPSE 235

Query: 239 VLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAE-T 297
           V++IAD  A  +FVA D+ +QAEH PD+  +L+T +   A+ V +AV   L  + R E  
Sbjct: 236 VVIIADESAHAEFVALDMFAQAEHDPDASAVLITTSESFAQAVQQAVASLLPTMLRHETI 295

Query: 298 ARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPES 357
           A   L+   +++   L     +S+   PEHL +      +++  +  AG++F+G +S E+
Sbjct: 296 ASSLLHNGAMVLVPSLDDACAVSDMLAPEHLELHVVQPWDILPKLKHAGAIFMGSYSCET 355

Query: 358 AGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLT 417
            GDY +G NH LPT G     S L + DF K  ++   S E   +  + I   A AE L 
Sbjct: 356 IGDYFAGPNHTLPTSGTARFFSPLSVRDFVKHTSIISYSPEQLRSKGAQIAAFADAEGLQ 415

Query: 418 AHKNAVTLRVNAL 430
           AH  AV +R+  L
Sbjct: 416 AHAEAVRVRLKTL 428


>UniRef50_C7LV94 Histidinol dehydrogenase n=6 Tax=Desulfovibrionales
           RepID=C7LV94_DESBD
          Length = 436

 Score =  538 bits (1388), Expect = e-151,   Method: Composition-based stats.
 Identities = 159/435 (36%), Positives = 232/435 (53%), Gaps = 13/435 (2%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
              +++ S          M    +  +++   V DIL  V+ RGDEA+ EY+ +FD  ++
Sbjct: 3   LRFLEYTSPNDWTAIASWMARRDAGEDNVEPLVRDILAQVRERGDEAVAEYTRRFDCPSL 62

Query: 64  TA--LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVT 121
           +A  L V   +I  A E +  E    +  A  NI  FH  QK         PG    Q+ 
Sbjct: 63  SAAGLPVPKADIGRALELIPAEDAAIIREAAANIRDFHLRQKQNSWITTPAPGTTLGQLV 122

Query: 122 RPVASVGLYIPGGSA---PLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQ 174
            PV   GLY+PGG     PL S++LM A PA +AG   + + SPP     +   IL  A 
Sbjct: 123 LPVDRAGLYVPGGQGGETPLISSLLMNAIPAQVAGVGAICVVSPPRKDGTLNPYILATAA 182

Query: 175 LCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPA 234
           + G+  +F  G A AIAALA+GT S+P+VD I GPGN FVT AKR +  ++    IDM A
Sbjct: 183 ILGIDTIFMCGSAWAIAALAYGTASIPRVDVIAGPGNIFVTTAKRLLVGQV---GIDMIA 239

Query: 235 GPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPR 294
           GPSE+ ++ADS A P ++A+D+LSQAEH P +  IL++    +   V + + RQL  LPR
Sbjct: 240 GPSEIAILADSTANPKWLAADMLSQAEHDPLASSILISADQQLLEEVKKELARQLPALPR 299

Query: 295 AETARQAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDW 353
            E A ++L   S LI   DL   +++ N+  PEH  +   +   LV ++ +AG+VF+G  
Sbjct: 300 QEIASKSLSEWSALIHVPDLEMGMDLINRLAPEHFELSVADPWALVGAVRNAGAVFMGHS 359

Query: 354 SPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAA 413
           +PE  GDY +G NHVLPT       S+L +  F K+ ++    +   ++  S +  LA  
Sbjct: 360 TPEPVGDYFAGPNHVLPTLSTARFSSALSVDTFCKKTSLICTDQAYMNSHGSKVARLARL 419

Query: 414 ERLTAHKNAVTLRVN 428
           E L AH  +V  R+ 
Sbjct: 420 EGLEAHARSVEQRLE 434


>UniRef50_Q4FQF8 Histidinol dehydrogenase n=6 Tax=Proteobacteria RepID=HISX_PSYA2
          Length = 431

 Score =  538 bits (1387), Expect = e-151,   Method: Composition-based stats.
 Identities = 171/434 (39%), Positives = 244/434 (56%), Gaps = 12/434 (2%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKT-- 61
              +       + Q   L+        ++  TV+DI+  V+  GD  + E + +FD+   
Sbjct: 1   MRQLSTQDADFDSQLTELLAFETVNDATLLTTVDDIIARVRHGGDSVVLELTQQFDQHPA 60

Query: 62  -TVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQV 120
            T  AL++S E +A A   L D +K A+  A   ++TFH  Q       E + G R  Q 
Sbjct: 61  TTTQALELSKEALAEAFANLDDVVKSALITAATRVKTFHERQVQETWQYEDELGNRLGQK 120

Query: 121 TRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCG 177
              +  VG+Y+PGG A   S+VLM A PA +AG K+V++  P P   +   +L AA L  
Sbjct: 121 VTALDRVGIYVPGGLASYPSSVLMNAIPAKVAGVKEVIMVVPAPKGVLNPLVLAAAHLAK 180

Query: 178 VQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPS 237
           V  VF +GGAQA+AALA+GTE++P VDKI GPGN +V  AKR V  ++    IDM AGPS
Sbjct: 181 VDRVFTIGGAQAVAALAYGTETIPAVDKITGPGNKYVAAAKRAVFGQV---GIDMIAGPS 237

Query: 238 EVLVIADSGA--TPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRA 295
           EVLV A+  A    D++A DLLSQAEH   +Q I +T +A   + VA  +E+ LAELP+A
Sbjct: 238 EVLVYAEGEAQDRADWLAMDLLSQAEHDRIAQAIFVTTSAQQLKEVAIEIEKALAELPKA 297

Query: 296 ETARQALNA-SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWS 354
           + AR +L     LI+ +D  + + + N+  PEHL +   +   L++SI  AG++F+G  +
Sbjct: 298 DIARDSLKNRGVLILVRDREEGMAVINRVAPEHLELSVDHPDALLNSIRHAGAIFMGRHT 357

Query: 355 PESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAE 414
           PE+ GDY +G NHVLPT G     S LG+ DFQK+ ++   S+ G   LA T + LA  E
Sbjct: 358 PEAIGDYCAGPNHVLPTSGTARFSSPLGVYDFQKKSSIIYCSESGSKPLAQTADILAQHE 417

Query: 415 RLTAHKNAVTLRVN 428
            L AH  +   R  
Sbjct: 418 DLEAHARSARYRYQ 431


>UniRef50_P62457 Histidinol dehydrogenase n=27 Tax=cellular organisms
           RepID=HISX_DESVH
          Length = 436

 Score =  538 bits (1387), Expect = e-151,   Method: Composition-based stats.
 Identities = 173/432 (40%), Positives = 239/432 (55%), Gaps = 13/432 (3%)

Query: 5   TIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVT 64
            I+   S         ++       +++   V DIL  V+++GDEAL EY+ +FD    T
Sbjct: 4   RILTLQSEAQWPLLGDMLAGRYDPDDAVEPVVRDILAAVRSKGDEALAEYTRRFDCPDFT 63

Query: 65  A--LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
              L V++EE+A A   +  +    +  A  NI +FH AQK     V    G    Q   
Sbjct: 64  PALLHVTSEEVAQAVASVPADDIAIIRQAADNIRSFHEAQKERSWFVTHDDGTILGQKVT 123

Query: 123 PVASVGLYIPGGSA---PLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQL 175
           PV   GLY+PGG     PL S++LM A PA +AG   + + SPP     +   +L AA +
Sbjct: 124 PVDRAGLYVPGGKGGDTPLLSSLLMNAIPAQVAGVTSITVASPPRPDGTLNPHLLAAAHI 183

Query: 176 CGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAG 235
            G+ D+   G A A+AA AFGT+++  VD I GPGN FVT AKR V  R+   AIDM AG
Sbjct: 184 LGITDIIRAGSAWAVAAFAFGTQTIAPVDVIAGPGNIFVTTAKRMVQGRV---AIDMIAG 240

Query: 236 PSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRA 295
           PSE+L++AD+ A PD+VA+D+LSQAEH P +  IL+T    +A  V   +ERQLA LPRA
Sbjct: 241 PSEILILADATARPDWVAADMLSQAEHDPLASSILVTTEPALAEAVTAELERQLATLPRA 300

Query: 296 ETARQAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWS 354
           + AR+AL +   ++V  D+   V I+N+  PEHL + T    EL  S+  AG++FLG +S
Sbjct: 301 DIARKALADWGAVVVVPDMDVAVAIANRVAPEHLEVLTAQPWELAGSLRHAGALFLGPYS 360

Query: 355 PESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAE 414
           PE  GDY +G NHVLPT G     S+L +  F KR ++   S+      A  +  LA  E
Sbjct: 361 PEPLGDYFAGPNHVLPTMGTARFSSALSVQTFCKRTSIIAASRAFAERNADAVARLARLE 420

Query: 415 RLTAHKNAVTLR 426
            L AH  +   R
Sbjct: 421 GLEAHARSAASR 432


>UniRef50_Q186D5 Histidinol dehydrogenase n=9 Tax=Bacteria RepID=Q186D5_CLOD6
          Length = 421

 Score =  537 bits (1385), Expect = e-151,   Method: Composition-based stats.
 Identities = 158/415 (38%), Positives = 232/415 (55%), Gaps = 13/415 (3%)

Query: 25  AISASESI-TRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDE 83
                E I    V+ I+++++   D AL++Y+ KFD+ T    +++ EEI  A + + DE
Sbjct: 10  KEKVDEKILREQVSSIIEDIRNNKDVALKKYNEKFDRNTRDEFRITKEEIKEAYKHVDDE 69

Query: 84  LKQAMAVAVKNIETFHTAQK---LPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFS 140
               + +A KNI  F  AQK     P + E  PGV   Q   P+ S   Y+PGG  PLFS
Sbjct: 70  FINNLKIAAKNIREFAKAQKLSFENPFEKEIYPGVILGQTNIPIESCLAYVPGGQYPLFS 129

Query: 141 TVLMLATPASIAGCKKVVLCSPP-----PIADEILYAAQLCGVQDVFNVGGAQAIAALAF 195
           T LML  PA +AG K++V CSP       I  + L A  + G  +++  GG QAIAA  +
Sbjct: 130 TALMLIIPAKVAGVKRIVACSPTMKNTEKINPKTLVAMDIAGADEIYATGGVQAIAAFTY 189

Query: 196 GTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASD 255
           GTE +  VD I GPGN FVTEAKRQ   ++    ID  AGPSEVL+IAD  + P ++A+D
Sbjct: 190 GTEKINPVDIIVGPGNKFVTEAKRQCYGQV---GIDFVAGPSEVLIIADETSNPVYIAAD 246

Query: 256 LLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNA-SRLIVTKDLA 314
           LL+Q EH  +++ ILLT + ++A++V + +E  L +LP  + +  +      +I+  D+ 
Sbjct: 247 LLAQCEHDLNARGILLTNSLEVAQKVEKNIESMLKDLPTKDISYSSWENNGEIILVDDME 306

Query: 315 QCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGY 374
           + ++ISN Y PEHL +      ++ D +T+ GS+F+G+ S E  GDY SGTNH LPT   
Sbjct: 307 EAIKISNFYAPEHLEVAVNEYNDICDRLTNYGSLFIGNLSAEVFGDYVSGTNHTLPTLKA 366

Query: 375 TATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNA 429
           +     + +  F K  T Q  +++   +LA   E LA  E L AH  A  +R   
Sbjct: 367 SRYTGGVWVGTFIKTCTKQIFNEKAIQSLAPVAEKLAKEEGLYAHAKAAEVRFKK 421


>UniRef50_Q313T7 Histidinol dehydrogenase n=7 Tax=Deltaproteobacteria
           RepID=HISX_DESDG
          Length = 434

 Score =  536 bits (1382), Expect = e-151,   Method: Composition-based stats.
 Identities = 167/438 (38%), Positives = 249/438 (56%), Gaps = 14/438 (3%)

Query: 1   MSFNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFD- 59
           M   T+   +    +  R +L     +   S+   V +I+D +++ GD AL  Y+ +FD 
Sbjct: 1   MPCRTLTYSSEADWQGIRDMLC-GRENPENSVEPVVREIMDAIRSDGDAALAGYTRRFDC 59

Query: 60  -KTTVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQ 118
                ++L+V+ + I  A+  +     Q +  A  NI  FH+AQK     +    G    
Sbjct: 60  PDFDPSSLRVAPDAIEKAAREIPRHDLQIITEAADNIRHFHSAQKEEAWFITRPDGTVLG 119

Query: 119 QVTRPVASVGLYIPGGSA---PLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILY 171
           Q+TRPV S GLY+PGG     PL S++LM A PA +AG  ++ + +PP     +   IL 
Sbjct: 120 QMTRPVDSAGLYVPGGQGGNTPLISSLLMNAVPAQVAGVPRIAVTTPPRKDGTLNPYILA 179

Query: 172 AAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAID 231
           AA + G+ +++  G A A+AALA+GT+++  VD I GPGN FVT AKR +   +    ID
Sbjct: 180 AAHVLGLDEIYCAGSAWAVAALAYGTQTIAPVDFIAGPGNIFVTTAKRMLIGTV---GID 236

Query: 232 MPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAE 291
           M AGPSE+L+IADS A    VA+D+LSQAEH P +  IL+TP+  +A  V   +E+Q+  
Sbjct: 237 MIAGPSEILIIADSQADAAHVAADMLSQAEHDPLASAILVTPSPQLAAAVHTELEKQVTG 296

Query: 292 LPRAETARQAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFL 350
           L RA+ AR +L + S ++VT DL   VE+SN+  PEHL +  ++   L+ SI +AG++F+
Sbjct: 297 LDRADIARASLRDWSAIVVTPDLNSAVELSNKVAPEHLELLVQDTWGLLGSIRNAGAIFM 356

Query: 351 GDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETL 410
           G  SPE  GDY +G NHVLPT G     S+L +  F K+ ++   S+      A+ I  L
Sbjct: 357 GPHSPEPVGDYFAGPNHVLPTMGTARFSSALSVQSFCKKSSIIAASQTFTQTNAAKIARL 416

Query: 411 AAAERLTAHKNAVTLRVN 428
           A  E L AH  +V  R++
Sbjct: 417 ARLEGLEAHARSVESRLS 434


>UniRef50_D1YWF4 Histidinol dehydrogenase n=1 Tax=Methanocella paludicola SANAE
           RepID=D1YWF4_METPS
          Length = 423

 Score =  532 bits (1370), Expect = e-149,   Method: Composition-based stats.
 Identities = 165/432 (38%), Positives = 236/432 (54%), Gaps = 15/432 (3%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
               +           ++  R    +S  +  T   + D V+  GD A+R+Y+ +FD   
Sbjct: 1   MIKQLY--GVDDAALDEVFKRRTSISS--VMDTAKKVADEVREGGDAAVRKYTKQFDGVD 56

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPP--VDVETQPGVRCQQV 120
           +  L+V+ +E+  A E +  E    +  A+ NIE FH  Q+        E  PG+R  Q 
Sbjct: 57  LRDLEVTDDEMYNAVELIDYETIGHLEKAIDNIEAFHALQRPSGDMWLTEISPGIRLGQK 116

Query: 121 TRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLC 176
             P+  +G Y+PGG+    ST LML  PA +AG  +++ C+PP     I    L A  + 
Sbjct: 117 FTPLERIGAYVPGGTGSYPSTALMLIVPAQVAGVSEIIACTPPRKDGTIHPLTLTALDMA 176

Query: 177 GVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGP 236
           G   +F VGG QAIAA+A+GT+S+PKV+KI GPGN +VT AK  V    D A IDMPAGP
Sbjct: 177 GADRIFKVGGVQAIAAMAYGTQSIPKVEKIVGPGNIYVTAAKMYVR---DAAEIDMPAGP 233

Query: 237 SEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAE 296
           SE++VIAD  A P F+ASD+++QAEH  ++  ILLTP+  +A  V   +ERQ    PR +
Sbjct: 234 SEIVVIADDTAIPSFIASDMIAQAEHDVNAMSILLTPSEMLAESVELEIERQKENAPRRQ 293

Query: 297 TARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPE 356
              +A     + V  DL   VE+ N+  PEH+ I  R+    ++ + +AG+V++GD++P 
Sbjct: 294 IIDKA--GMGIYVLDDLDAAVEVCNRIAPEHVEIMVRDPMSTLNKVRNAGTVYVGDYAPV 351

Query: 357 SAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERL 416
           +AGDYASG NHVLPT GY    S +    F K  +VQ + K G   +  TI  LA  E  
Sbjct: 352 AAGDYASGANHVLPTGGYAKVFSGMNTMQFIKTTSVQVIEKGGLEGIKDTITALAEIEGF 411

Query: 417 TAHKNAVTLRVN 428
            AH  +V  R  
Sbjct: 412 DAHARSVYKRFE 423


>UniRef50_A9A0A6 Histidinol dehydrogenase n=2 Tax=Desulfobacteraceae
           RepID=A9A0A6_DESOH
          Length = 434

 Score =  530 bits (1365), Expect = e-149,   Method: Composition-based stats.
 Identities = 163/436 (37%), Positives = 248/436 (56%), Gaps = 13/436 (2%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
             I    +  A+++   ++   +  +      V  I+ +VK  GD+AL  Y+ +FD   +
Sbjct: 1   MKIYTSGTPEADRRLDRIINRGLDYTPEQLHQVAAIVADVKKNGDKALERYTRQFDAPKL 60

Query: 64  TA--LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVT 121
            A   +V+A E+A A++ +     +A+  A+  +  FH          E +PGV   +  
Sbjct: 61  AASGFRVTAAEMAGAAKEVDRSFVKAINRAIGQVSEFHAMGLEKTWTAEPRPGVVVGKKV 120

Query: 122 RPVASVGLYIPG---GSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQ 174
            PV S G+Y+PG   G  PL STVLM A PA  AG +++V+ +PP     +   +L AA+
Sbjct: 121 TPVDSAGIYVPGATGGRTPLVSTVLMGAIPAKTAGVRRIVMVTPPRQDGTVNPHLLVAAK 180

Query: 175 LCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPA 234
             GV +++ VG A AIAALA GT+++ +VD I GPGN +V  AK+ V+  +    IDM A
Sbjct: 181 KVGVHEIYKVGSAWAIAALAHGTKTIARVDMIAGPGNIYVALAKKIVAGTV---GIDMMA 237

Query: 235 GPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPR 294
           GPSE+LV+AD  A P ++A+DLLSQAEH   S  +L+T +  +AR V++ V+RQ   + R
Sbjct: 238 GPSEILVVADGSADPRYIAADLLSQAEHDALSAAVLVTTSMKVARAVSDEVKRQTTGISR 297

Query: 295 AETARQALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDW 353
            + AR+AL     + V K   +   + N++ PEHL + T+N  + +D I +AG+VFLG +
Sbjct: 298 WQIARKALAAYGAVFVVKSKKEAFALVNRFAPEHLELHTKNPEKDLDQIRNAGAVFLGPY 357

Query: 354 SPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAA 413
           +PE  GDY +G NH LPT G     S+L  A F KR ++   SK  F + A+ +  +AA 
Sbjct: 358 TPEPIGDYVAGPNHTLPTSGCARFASALSTAHFLKRTSIVSYSKAAFLSEAADVMRIAAV 417

Query: 414 ERLTAHKNAVTLRVNA 429
           E L AH NAV +R+  
Sbjct: 418 EGLDAHANAVGVRLEE 433


>UniRef50_Q5ZW87 Histidinol dehydrogenase n=6 Tax=Legionella RepID=HISX_LEGPH
          Length = 431

 Score =  530 bits (1365), Expect = e-149,   Method: Composition-based stats.
 Identities = 191/435 (43%), Positives = 277/435 (63%), Gaps = 9/435 (2%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
             TI +W   +   ++  L RP    S +I   V +I++ V+  GD+AL + + +FD+  
Sbjct: 1   MLTIKNWQLLSENDKKLCLSRPRQ--SSAIKENVLEIINQVQLSGDKALYDLTKQFDRVN 58

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
           +  L+V  E+I  A   +      A+  A+  I ++H +      ++ T  G+  + V R
Sbjct: 59  LQYLQVPQEKIEQA--NIPKNALNAITQAIGTISSYHQSLLPENTEISTASGITIRNVYR 116

Query: 123 PVASVGLYIPGG-SAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCG 177
           P+  VGLY+PGG   PL S++LM A PA +AGC   VLC+PP     I + IL AA+LCG
Sbjct: 117 PIQKVGLYVPGGNKTPLVSSLLMQAIPAKVAGCPIKVLCTPPDAEGEINEHILVAARLCG 176

Query: 178 VQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPS 237
           +  ++ +GGAQAIAA+A+GTESV KVDKIFGPGN++VT+AK  V+   DGAAIDMPAGPS
Sbjct: 177 IDTIYAIGGAQAIAAMAYGTESVIKVDKIFGPGNSYVTQAKTLVAIDADGAAIDMPAGPS 236

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAET 297
           EV+++AD+ A P+F+A+DLL+QAEHGPDSQVIL+    ++A +V + +E Q++ L R E 
Sbjct: 237 EVMILADTEANPEFIAADLLAQAEHGPDSQVILICDECELANQVNQQLEIQMSYLSRIEF 296

Query: 298 ARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPES 357
            +++L  SR+I+  + ++ ++I N Y PEHLII  +N    V+ I +AG+VFLG W+ E+
Sbjct: 297 IKRSLANSRIIICSNQSEQLDIINSYAPEHLIINRKNPEPWVEKIVAAGTVFLGSWAAET 356

Query: 358 AGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLT 417
            GDY +G+NHVLPT G+    S L   DF  R TVQ +++E    L     TLA  E L 
Sbjct: 357 MGDYVTGSNHVLPTSGFARNHSGLSTLDFMTRFTVQAINQEAIRNLGPAAMTLAELEGLD 416

Query: 418 AHKNAVTLRVNALKE 432
           AH NAV +R+N L +
Sbjct: 417 AHANAVQIRLNTLGD 431


>UniRef50_Q9X0D1 Histidinol dehydrogenase n=6 Tax=Thermotogaceae RepID=HISX_THEMA
          Length = 428

 Score =  530 bits (1365), Expect = e-149,   Method: Composition-based stats.
 Identities = 155/439 (35%), Positives = 249/439 (56%), Gaps = 20/439 (4%)

Query: 1   MSFNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDK 60
           M        N+   ++  +LL +   S S  +  TV +I+  VK  GD AL E+  +F+K
Sbjct: 1   MILM-----NNPGDKEVLRLLKQRMESVS-QVEETVKEIIRRVKEEGDRALEEFLKRFEK 54

Query: 61  --TTVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQ 118
               +  L+V+ +EI+ A  ++ +E  + + + +++++ FH  Q+       T+ G    
Sbjct: 55  HPVGIENLRVTEKEISEA--QVEEEFVETIKIVIEDLKEFHRRQEERSFFFTTKGGSFLG 112

Query: 119 QVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQ 174
           ++  P+ SVG+Y+PGG  P FST+LM A PA +AG +++ + +PP     I+  IL   +
Sbjct: 113 EMVVPLESVGIYVPGGKVPYFSTLLMCAVPAIVAGVERIAVTTPPNENGGISPYILKTCE 172

Query: 175 LCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPA 234
           + G+++++ +GGA A+AAL +GTE+V  VDKI GPG  FVT AK+ V   +    ID  A
Sbjct: 173 ILGLKEIYRMGGAHAVAALTYGTETVKPVDKIVGPGGVFVTLAKKHVYGDV---GIDSIA 229

Query: 235 GPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELP- 293
           GPSE+ ++ D  A  D +A+D LSQAEH  ++  +++T + ++  ++ + +ER L  LP 
Sbjct: 230 GPSEIAIVTDGSADLDLIAADFLSQAEHDENAMSVVITTSKEVFEKLPQVIERHLEALPE 289

Query: 294 -RAETARQALNA-SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLG 351
            R +TAR +      +I+T  L +  EISN   PEHL +   N  E +  I +AGSVFLG
Sbjct: 290 ERRKTARISTENFGTIILTDSLKRAFEISNLIAPEHLEVLVENPFEPLGHIKNAGSVFLG 349

Query: 352 DWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLA 411
            ++ ES GDY +G NHVLPT+      S L ++DF K++ +  LS+E F   +     +A
Sbjct: 350 KYTCESVGDYGAGPNHVLPTFRSARFSSGLRVSDFTKKIFITHLSEEDFRRKSELYSKMA 409

Query: 412 AAERLTAHKNAVTLRVNAL 430
             E   AH  A+ +R   L
Sbjct: 410 RWEGFEAHARAIDVRREKL 428


>UniRef50_B9KYT3 Histidinol dehydrogenase n=1 Tax=Thermomicrobium roseum DSM 5159
           RepID=B9KYT3_THERP
          Length = 448

 Score =  526 bits (1355), Expect = e-148,   Method: Composition-based stats.
 Identities = 162/414 (39%), Positives = 238/414 (57%), Gaps = 9/414 (2%)

Query: 23  RPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSD 82
           R       +  + V  I+D+V+++GD+A+R Y+  FD   +     + EE   A   ++ 
Sbjct: 37  RAVFGGDLTPLQVVERIIDDVRSQGDDAVRRYTLAFDGAHLDTFLATPEEFLRARRAITP 96

Query: 83  ELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTV 142
           EL+ A+  A   I  FH            + G    Q+ RPV  VG+Y+PGG APL S++
Sbjct: 97  ELEAALRFARDRIVAFHRRAIPRSWIEFDETGAF-GQLVRPVDRVGIYVPGGRAPLPSSL 155

Query: 143 LMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQDVFNVGGAQAIAALAFGTE 198
           LM A PA +AG + +V+C+PP     I+  +L AA+L G++ VF +GGAQAIAALA+GT+
Sbjct: 156 LMTAIPAQLAGVRDIVVCTPPGRDGTISPAVLAAAELLGIERVFKIGGAQAIAALAYGTQ 215

Query: 199 SVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLS 258
           +VP VD + GPGN FV  AKR V   +    ID   GP+E L+IAD  A P   A+DLL+
Sbjct: 216 TVPAVDIVAGPGNLFVVLAKRLVYGDV---GIDQLPGPTETLLIADEQADPVLCAADLLA 272

Query: 259 QAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALN-ASRLIVTKDLAQCV 317
           QAEH P +  IL+TPA  +A +VA+ +ERQL +L R+E AR AL     +I+  DL +  
Sbjct: 273 QAEHDPLACAILITPARTLAHKVAQELERQLQQLDRSEIARAALEANGAIIIVPDLERAF 332

Query: 318 EISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTAT 377
           +++N + PEHL +  R+    +D +  AG VFLG+ SPE  GDY +G +HV+PT      
Sbjct: 333 DLANLFAPEHLCLLVRDPWRYLDRVRHAGGVFLGETSPEVIGDYTAGPSHVMPTGRTARF 392

Query: 378 CSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNALK 431
            S + +  F K  ++  ++ +    L S    LA +E LTAH  A+  R+   +
Sbjct: 393 ASPVTVQTFLKVTSLVAVAPKALEQLGSPALQLAMSEGLTAHAAAIEHRLERTR 446


>UniRef50_Q3B5E3 Histidinol dehydrogenase n=8 Tax=Chlorobiaceae RepID=HISX_PELLD
          Length = 443

 Score =  523 bits (1347), Expect = e-147,   Method: Composition-based stats.
 Identities = 152/434 (35%), Positives = 234/434 (53%), Gaps = 10/434 (2%)

Query: 1   MSFNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDK 60
           ++   +  +     +   + + R ++     + R V DIL+ V+ RGD A+ EY+ +F  
Sbjct: 14  VAVLKLYRFLD-DRDALFRQIGR-SVDFDPEVQRAVTDILEAVRLRGDMAVLEYTERFQG 71

Query: 61  TTVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQV 120
             +T+++V  E+I  A E       + +  A +NI  FH  +       E + GV   Q 
Sbjct: 72  AVLTSMQVPEEDILRAREEADPAFIRVLEEAWENILRFHRHEVENSFFYEGEGGVVLGQR 131

Query: 121 TRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSP----PPIADEILYAAQLC 176
             P+    LY+PGG A   S+VLM A PA +AG  ++ + +P      ++  IL AA + 
Sbjct: 132 VTPMDRAMLYVPGGKASYPSSVLMNAAPARVAGVGEIFMTTPCDASGAVSPHILAAASVA 191

Query: 177 GVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGP 236
           GV  V+ +GGAQA+AA A+GT+++PKVD I GPGN +V  AK+QV   +   AID  AGP
Sbjct: 192 GVTSVYRLGGAQAVAAFAYGTQTIPKVDIITGPGNKYVALAKKQVFGHV---AIDSIAGP 248

Query: 237 SEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAE 296
           SEV+V+AD  A  +F+  DL +QAEH PD+  +L+TP+  +A  V +    ++  + R E
Sbjct: 249 SEVVVVADDDADAEFITMDLFAQAEHDPDASSVLITPSMRLAEEVRDLAAARVGSMLRGE 308

Query: 297 TARQAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSP 355
              +AL N   ++V  D+ +   +S+   PEHL +   +  EL+ SI  AG+VF+G +S 
Sbjct: 309 VIAEALSNNGAIVVVADIEEACRVSDMIAPEHLELHVLHPWELLASIRHAGAVFMGGYSC 368

Query: 356 ESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAER 415
           E+ GDY +G NH LPT G     S L + DF K  ++   ++    A    I + A  E 
Sbjct: 369 ETVGDYYAGPNHTLPTNGTARFFSPLSVRDFVKHTSIISYTRRQIMACGERIASFADHEG 428

Query: 416 LTAHKNAVTLRVNA 429
           L AH  AV  R+  
Sbjct: 429 LEAHAEAVRARLKK 442


>UniRef50_Q87C29 Histidinol dehydrogenase n=66 Tax=cellular organisms
           RepID=HISX_XYLFT
          Length = 431

 Score =  519 bits (1337), Expect = e-146,   Method: Composition-based stats.
 Identities = 216/428 (50%), Positives = 281/428 (65%), Gaps = 5/428 (1%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
             IIDWN      Q + L RPA + +      V  +++ V+  GD ALR+ +A+FD   +
Sbjct: 1   MKIIDWNQLDTAAQAKTLTRPAQTIATQTREAVTALIEQVRRGGDTALRDITARFDGVDL 60

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRP 123
              +V+A E+AAA+  ++ EL+ AM  A   IE FH A       VET PGV C+++ RP
Sbjct: 61  ATFEVTAAELAAAATAVAPELQHAMQTAAARIEAFHRAGMTNDYRVETAPGVVCERLVRP 120

Query: 124 VASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPI----ADEILYAAQLCGVQ 179
           +A VGLY+P GSAPLFST LML  PA +AGC++VVLC+PP         +L AA+L GV 
Sbjct: 121 IARVGLYVPAGSAPLFSTALMLGVPARLAGCREVVLCTPPSKDGRANPAVLLAARLTGVT 180

Query: 180 DVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEV 239
            VF +GGAQAIAA+A+GT SVP  DK+FGPGN+FVTEAK+Q++ +    AIDMPAGPSEV
Sbjct: 181 RVFTLGGAQAIAAMAYGTASVPTCDKVFGPGNSFVTEAKQQLA-QAGVVAIDMPAGPSEV 239

Query: 240 LVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETAR 299
           LVIAD+ A P F+A+DLLSQAEHGPDSQV+LL+ +  +   V  A+  QL +L RAE AR
Sbjct: 240 LVIADAAANPAFIAADLLSQAEHGPDSQVLLLSDSDALMTAVQNALALQLQQLSRAEIAR 299

Query: 300 QALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAG 359
           QAL  SR I    L    +ISN+Y PEHLI+  R  R  +  + +AGSVFLGD++PE+ G
Sbjct: 300 QALAHSRFIKVATLETAFDISNRYAPEHLILALRQPRAWLHRVAAAGSVFLGDYTPEALG 359

Query: 360 DYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAH 419
           DY SGTNHVLPT G     S + ++ FQ  ++VQ  S+ G + +     TLA AE L AH
Sbjct: 360 DYCSGTNHVLPTGGAARAYSGVSVSSFQNMISVQAASRSGIAEIGGCALTLARAEGLDAH 419

Query: 420 KNAVTLRV 427
            NAV LR+
Sbjct: 420 ANAVALRM 427


>UniRef50_Q3ZXL7 Histidinol dehydrogenase n=5 Tax=Dehalococcoides RepID=HISX_DEHSC
          Length = 436

 Score =  519 bits (1337), Expect = e-146,   Method: Composition-based stats.
 Identities = 158/422 (37%), Positives = 241/422 (57%), Gaps = 14/422 (3%)

Query: 12  CTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAE 71
               ++ +L  R  +       + VN I+ +V+ +GDEA+  Y+ KFD+  ++ L+V   
Sbjct: 24  LDETERTELARRLGVDP----EKAVNGIIADVRKQGDEAVLGYTLKFDRANLSKLEVGQP 79

Query: 72  EIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYI 131
           EI  A+  +  EL +A+ +A   I  +H  QK      +T   ++ +Q+ RP+  VGLY+
Sbjct: 80  EIQQAASEIPAELFEALQLAASQIRAYHRFQKEAVW--KTAEIMQGKQLIRPLERVGLYV 137

Query: 132 PGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQDVFNVGGA 187
           PGG A   STVLM A PA  AG K+++L +PP     I    L AAQ+ GV  +F  GGA
Sbjct: 138 PGGKAFYPSTVLMTAIPAREAGVKEIILVTPPGANGKIPAPTLAAAQIAGVDRIFACGGA 197

Query: 188 QAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGA 247
           QA+AALAFGT+S+PKVDKI GPGN FVT AK+ V   +D   ID   GPSEVL++AD  A
Sbjct: 198 QAVAALAFGTKSIPKVDKICGPGNIFVTLAKKAVFGVVD---IDGLQGPSEVLIVADQYA 254

Query: 248 TPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASR 306
             ++ ASD+L+QAEH   +  IL+T + D+A RV + VE +     R +  +Q+L +   
Sbjct: 255 NAEYCASDILAQAEHDALASSILITTSEDLANRVNDIVESKADTCSRRDIIKQSLRDNGL 314

Query: 307 LIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTN 366
           + V  ++ + ++++N Y  EHL +  +++ + +  I  AG +F G+ +    GDY +G +
Sbjct: 315 IAVVDNINEAIKLANMYAAEHLCLLVKDSEKYLTQINHAGCIFYGEKASVVMGDYVAGPS 374

Query: 367 HVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
           H LPT G     S L + DF K + + ++ K+  + L     T+A AE L  H  AV  R
Sbjct: 375 HALPTSGTARFSSPLNILDFVKYIDIVKVDKQDIAKLGQAAATIAKAEGLECHAEAVLKR 434

Query: 427 VN 428
           + 
Sbjct: 435 LE 436


>UniRef50_Q9P777 Histidinol dehydrogenase n=71 Tax=cellular organisms
           RepID=HISX_SCHPO
          Length = 439

 Score =  519 bits (1337), Expect = e-145,   Method: Composition-based stats.
 Identities = 193/427 (45%), Positives = 267/427 (62%), Gaps = 9/427 (2%)

Query: 7   IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTAL 66
               + TAE++ +LL RP  + ++ I   V  I+++VK+RG+ +L +Y++KF+K  + + 
Sbjct: 11  YRAAALTAEERTRLLARPIQN-TQKIRTIVQPIIEDVKSRGEASLIDYASKFEKVQLKS- 68

Query: 67  KVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVAS 126
            V          ++S  +K+ + +A  NI  FH++Q  P + V+T  GV CQ+++RP+  
Sbjct: 69  AVLKAPFDDDLMKISPMIKEDIDIAFNNIFAFHSSQLRPTIAVQTMRGVVCQRMSRPINR 128

Query: 127 VGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSP----PPIADEILYAAQLCGVQDVF 182
           VGLYIPGG+A L ST LML  PA +AGC  VV+ +P      +A EI+Y A   G + + 
Sbjct: 129 VGLYIPGGTAVLPSTALMLGVPAKVAGCPHVVISTPVRKDGTVAPEIVYIANKIGAEAII 188

Query: 183 NVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDG-AAIDMPAGPSEVLV 241
             GGAQAIAA+A+G   VPKV+KIFGPGN FVT AK  V        AID+PAGPSEVLV
Sbjct: 189 LAGGAQAIAAMAYGISGVPKVNKIFGPGNQFVTAAKMHVQNDYGALVAIDLPAGPSEVLV 248

Query: 242 IADSGATPDFVASDLLSQAEHGPDSQVILLTPA--ADMARRVAEAVERQLAELPRAETAR 299
           IAD    P+ VA DLLSQAEHG DSQ+ILLT +   +M  R+ +A+      L R+   +
Sbjct: 249 IADETCNPESVALDLLSQAEHGLDSQIILLTVSLSPEMFDRIQKAINDHALRLSRSYIIK 308

Query: 300 QALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAG 359
            A+  S ++   ++ Q  E SN YGPEHL++  +NA   +  I +AGSVF+G WSP S G
Sbjct: 309 HAIKKSVIVQVDNVDQAFEWSNLYGPEHLVLHLKNASSYIPKIDNAGSVFVGPWSPVSMG 368

Query: 360 DYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAH 419
           DYASGTNH LPTYGY ++ S +    F K +T QEL++EG   L  T+  LA  E LTAH
Sbjct: 369 DYASGTNHTLPTYGYASSYSGVSTDSFLKYITTQELTEEGIQRLGPTVIRLAELEGLTAH 428

Query: 420 KNAVTLR 426
            +AV +R
Sbjct: 429 ADAVRVR 435


>UniRef50_B3DXR9 Histidinol dehydrogenase n=1 Tax=Methylacidiphilum infernorum V4
           RepID=B3DXR9_METI4
          Length = 426

 Score =  516 bits (1330), Expect = e-145,   Method: Composition-based stats.
 Identities = 150/430 (34%), Positives = 251/430 (58%), Gaps = 8/430 (1%)

Query: 1   MSFNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDK 60
           M    I+ +     +Q+++ L R  +  S+ I +TV  +L+ +   GD+A+  Y+ +FDK
Sbjct: 3   MIDFKILRFGDLNWQQEKKGLSRFYL-PSKEIEQTVRRVLEEIIRNGDKAVSLYTEQFDK 61

Query: 61  TTVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQV 120
            +++     A  I   + +   ++  A+  A +NI  F  A K     +  + G R  + 
Sbjct: 62  QSISP---GAFRITEKAPQPPKDVVDALRWAKRNILCFAKANKPKNWSITNREGARVGEY 118

Query: 121 TRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQD 180
             P   +G+Y+PGG+APL ST LM    A  AG K++V+CSPPP+   + ++    G  +
Sbjct: 119 YTPFRRIGVYVPGGTAPLISTALMTVCFAKAAGVKEIVVCSPPPVNPILHFSIIYSGATE 178

Query: 181 VFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVL 240
           ++ +GG QAI ALA+GTES+PKV+KIFGPGNA+V EAKRQV   +   +ID+  GPSE+ 
Sbjct: 179 IYRIGGIQAIGALAYGTESIPKVEKIFGPGNAYVVEAKRQVIGPV---SIDLLPGPSEIA 235

Query: 241 VIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQ 300
           V A   A P+F+A+DLL+QAEHGP S+++ ++P   +   V  A+ RQL  L R +  ++
Sbjct: 236 VFASWPANPEFIAADLLAQAEHGPSSKILFVSPENSLLESVIGAINRQLPSLKRQQILKE 295

Query: 301 AL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAG 359
            L + +  +  + + + + + N + PEHL +Q   A++ +    + G+++LG +S  +AG
Sbjct: 296 VLTDHAYFVQVRSIDEGIGLINDFAPEHLSLQIPGAKKYLAQFKNCGAIYLGPYSAVAAG 355

Query: 360 DYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAH 419
           D+ +G +H LPT G   + S L ++ F ++ +V E SK+    ++S +ET A  E L AH
Sbjct: 356 DFLAGPSHTLPTGGAAKSFSGLTMSHFYRKTSVVEYSKKALCRVSSLLETFARIESLDAH 415

Query: 420 KNAVTLRVNA 429
             ++T+R  +
Sbjct: 416 GASITIRKES 425


>UniRef50_Q4P7D9 Putative uncharacterized protein n=3 Tax=Eukaryota
           RepID=Q4P7D9_USTMA
          Length = 896

 Score =  516 bits (1330), Expect = e-145,   Method: Composition-based stats.
 Identities = 205/461 (44%), Positives = 275/461 (59%), Gaps = 34/461 (7%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
                +   +A Q+++LL RPA+  +E +      IL +VK RGD AL E + KFDK  +
Sbjct: 438 IQSYRYEDLSAAQRKELLKRPALR-TEQVMDICRPILRSVKERGDAALLELTEKFDKAKL 496

Query: 64  TA-LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLP----------------- 105
           T  +++      +   ++  E+K A+ +A  NI  FH AQK                   
Sbjct: 497 TNAVRLPPFVDDSVMAQIKPEVKVAIDIAYNNIYKFHKAQKTTFGNKSAGATGSGSADGS 556

Query: 106 ------PVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVL 159
                  ++VET PGV C++  RP+ SVGLY+PGGSA L ST LML  PA +A C  VV+
Sbjct: 557 EGAQDGVLEVETMPGVVCRRFARPIESVGLYVPGGSAVLPSTALMLGVPAQVARCPTVVI 616

Query: 160 CSPP----PIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVT 215
            +PP     I+ E+LY A       +   GGAQA+AALA+GTES PKVDKI GPGN FVT
Sbjct: 617 ATPPRADGSISPEVLYCASKVNASAILCAGGAQAVAALAYGTESCPKVDKIVGPGNQFVT 676

Query: 216 EAKRQVSQRLDG-AAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILL--- 271
            AK  V    D   +IDMPAGPSEVLVIAD  A   FVASDLLSQAEHGPDSQV+L+   
Sbjct: 677 AAKMLVQNETDAIVSIDMPAGPSEVLVIADREADAAFVASDLLSQAEHGPDSQVVLVGIA 736

Query: 272 TPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQ 331
             ++++A  +   V+RQ   LPR +  RQA++ S  ++  D A  +E SN Y PEHLI+Q
Sbjct: 737 LSSSELA-AIEAEVDRQARALPRVDVVRQAIDKSVTVIVPDRATAMEWSNAYAPEHLILQ 795

Query: 332 TRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMT 391
           TR+A  LV+ + +AGS+F+G WSPES GDY SGTNH LPT  Y  + S + +A F+K +T
Sbjct: 796 TRDAESLVECVQNAGSIFVGPWSPESCGDYMSGTNHSLPTAAYAKSYSGVNVATFEKCIT 855

Query: 392 VQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNALKE 432
            Q L+++G    A  +  LA  E L AH  AV +R++ ++ 
Sbjct: 856 SQSLTQQGLKGFAQNVIDLAMCEGLQAHAMAVKIRLDRIQS 896


>UniRef50_A3EUM9 Histidinol dehydrogenase n=3 Tax=Leptospirillum RepID=A3EUM9_9BACT
          Length = 445

 Score =  515 bits (1327), Expect = e-144,   Method: Composition-based stats.
 Identities = 156/422 (36%), Positives = 239/422 (56%), Gaps = 11/422 (2%)

Query: 20  LLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT--VTALKVSAEEIAAAS 77
           +  R   S  E++   V+ IL +++  GD AL  Y+ + D     +  L+VS   +  + 
Sbjct: 24  IFQRGRDSEGETLRARVSSILGDIRREGDVALLRYARELDGFRGELKDLRVSPGRMEESF 83

Query: 78  ERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAP 137
             L  E+++A+  A   IE FH A +   +        +   + RP+  VG+Y+PGG+A 
Sbjct: 84  GALPSEIRKALVFAKDRIEEFHGALREKGLSGLASRPGKGGVLVRPLHRVGVYVPGGTAA 143

Query: 138 LFSTVLMLATPASIAGCKKVVLCSP---PPIADEILYAAQLCGVQDVFNVGGAQAIAALA 194
             STVLM A  A +AG K++V  SP     I D IL A  +CGVQDV+ VGG  AIAA+A
Sbjct: 144 YPSTVLMTAVVAKVAGVKQIVGVSPAGPGGIPDAILAAFHVCGVQDVYQVGGVHAIAAMA 203

Query: 195 FGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVAS 254
           +GT ++P+VDKI GPGN +V EAKRQV   +D   IDM AGP+E+L++AD  A P+++A+
Sbjct: 204 YGTGTIPRVDKIVGPGNRYVAEAKRQVFGDVD---IDMVAGPTEILILADDSARPEWLAA 260

Query: 255 DLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDL 313
           D+++QAEH   +  +L+     +A+ V  A+ERQ++ LPR + A ++L     ++V   +
Sbjct: 261 DMIAQAEHDTRASAVLILTDMTLAKAVVLALERQISSLPRQKIAEESLLKYGFILVVPSV 320

Query: 314 AQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYG 373
              VEIS+   PEHL +Q RN  + +  I +AG+VFLG    E+ GDY  G +HVLPT G
Sbjct: 321 QVAVEISDLVAPEHLELQVRNPEKWLGLIQNAGAVFLGSEMAEAFGDYCFGPSHVLPTNG 380

Query: 374 YTATCSSLGLADFQKRMTVQE--LSKEGFSALASTIETLAAAERLTAHKNAVTLRVNALK 431
                S + +  F KR ++ E   S++    +      LA  E L  H  +   R+  ++
Sbjct: 381 SARFSSPVSIETFTKRTSLLEGFRSRQELEDVVRNSALLARLEGLEGHARSALARLENVQ 440

Query: 432 EQ 433
           ++
Sbjct: 441 KE 442


>UniRef50_C7NG13 Histidinol dehydrogenase n=2 Tax=Bacteria RepID=C7NG13_KYTSD
          Length = 439

 Score =  513 bits (1323), Expect = e-144,   Method: Composition-based stats.
 Identities = 218/435 (50%), Positives = 285/435 (65%), Gaps = 4/435 (0%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
             ++DWN+    ++   L RPA +  E +T  V ++LD V+ARG +A+  Y+ +FD    
Sbjct: 1   MRVLDWNALDDSERTAALERPAQAVGEQVTAAVAEVLDAVRARGADAVVGYTERFDGVGR 60

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRP 123
             L +S  EI  A E++ D ++ A+A A   + TFH    L P  V+T PG+RC+++ RP
Sbjct: 61  EHLLLSEAEIDRAVEQVPDAVRAAIAQAAATLRTFHAPGALSPFAVDTAPGMRCERIVRP 120

Query: 124 VASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPI----ADEILYAAQLCGVQ 179
           V +VGLY+P GSAPL ST LML  PA +AGC +VV+C+PP         ++ A    G++
Sbjct: 121 VRTVGLYVPAGSAPLPSTALMLGVPAVLAGCPEVVVCTPPTAQGTADPSVVAACVEVGIR 180

Query: 180 DVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEV 239
            +  VGGAQA+ A+AFG   +P+ DKIFGPGN+FVTEAKRQV+    G  ID+PAGPSE 
Sbjct: 181 RIAVVGGAQAVGAMAFGAGPIPRCDKIFGPGNSFVTEAKRQVAGMQGGPGIDLPAGPSEQ 240

Query: 240 LVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETAR 299
           LVIAD+GA P +VA+DLLSQAEHGPDSQV+ ++   D+  +VA  VERQ AELPRA+   
Sbjct: 241 LVIADAGANPVWVAADLLSQAEHGPDSQVVCVSDDRDLLEQVAAEVERQAAELPRAQIVA 300

Query: 300 QALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAG 359
            AL ASRL++  DL Q V +SN Y PEHLI+  R  REL+  IT+AGS+FLGD +PES G
Sbjct: 301 GALTASRLVLVDDLDQAVAVSNAYAPEHLILAVRAPRELLAGITAAGSIFLGDHTPESLG 360

Query: 360 DYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAH 419
           DY SGTNHVLPT G       + LA FQ  +TVQE S    + L +T  TLA AE L AH
Sbjct: 361 DYCSGTNHVLPTSGAARYTGGVNLASFQLSITVQEASPRALAQLGATAVTLARAEGLEAH 420

Query: 420 KNAVTLRVNALKEQA 434
             AVT RV+A +  A
Sbjct: 421 ARAVTRRVDASEAAA 435


>UniRef50_A5D1M4 Histidinol dehydrogenase n=1 Tax=Pelotomaculum thermopropionicum SI
           RepID=A5D1M4_PELTS
          Length = 437

 Score =  513 bits (1321), Expect = e-144,   Method: Composition-based stats.
 Identities = 153/440 (34%), Positives = 237/440 (53%), Gaps = 14/440 (3%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
           +  +      +AE   +++ R  +    S+   V  ++ +VK+RGD+AL +Y+ +FD  T
Sbjct: 2   YIQVFRLKEMSAEDYNRIMKRSEVETD-SVIGEVKKVIADVKSRGDDALVDYTREFDGIT 60

Query: 63  V--TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPP-VDVETQPGVRCQQ 119
           +    ++VS EEI  A  ++  E  +A+     N+  FH AQ       +E  PG+   Q
Sbjct: 61  ISAEKIRVSPEEIKEAYHKVDRETVEAIKTLAGNVRRFHAAQMPNKMWSMEVSPGLVAGQ 120

Query: 120 VTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSP----PPIADEILYAAQL 175
           V  P+  VG Y+PGG     S V+M   PA +AG  +V++C+P      +    L A  +
Sbjct: 121 VIIPLDRVGCYVPGGRGWFPSAVMMSVLPARVAGVPEVIVCTPSAPDGSVPPGTLVACDI 180

Query: 176 CGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAG 235
           CG   VF +GG+QA+AA+A+GT++VPKVDKI GPG+ +V  A + +   ++   I   AG
Sbjct: 181 CGADAVFRIGGSQAVAAMAYGTQTVPKVDKIVGPGSKWVLAAFKLLYGEVE---IGTHAG 237

Query: 236 PSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELP-- 293
           P E L+IAD  A P+F A+D+  QAEHG DS  +L+T   ++A  V + + R +  L   
Sbjct: 238 PGEGLIIADETADPEFAAADICIQAEHGLDSAGVLVTHVEELAWAVQKKIARHIERLNEY 297

Query: 294 RAETARQALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGD 352
           R     ++L     +I+T  L + +  +N Y  EHL I TR+   ++  I +AG ++LG 
Sbjct: 298 RKNFVVESLKKYGAIIITSSLEESIAFANDYAVEHLEIMTRDPLHVMQKIKNAGGIYLGH 357

Query: 353 WSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAA 412
           ++P S G + SG NHVLPT         L  ADF K +T + LS+EG ++L   +  LA 
Sbjct: 358 YTPLSCGCFGSGPNHVLPTGRKAKVSGGLKTADFYKAVTFEYLSREGLASLKDAMVKLAE 417

Query: 413 AERLTAHKNAVTLRVNALKE 432
            E   AH NA+  R    + 
Sbjct: 418 YEGFPAHGNAILERFAREQS 437


>UniRef50_C8WUX6 Histidinol dehydrogenase n=2 Tax=Alicyclobacillus acidocaldarius
           RepID=C8WUX6_ALIAD
          Length = 426

 Score =  512 bits (1320), Expect = e-144,   Method: Composition-based stats.
 Identities = 171/430 (39%), Positives = 245/430 (56%), Gaps = 9/430 (2%)

Query: 7   IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTAL 66
           +  +     +Q     R        +   V  I++ V+  GD+ALR  +   D      L
Sbjct: 1   MRLDRVDVIEQASFNWRRTTGRDADVWEKVERIVEEVRVGGDDALRRLTRALDGVD-APL 59

Query: 67  KVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVAS 126
           +V  E + AA   L  E+++A+A A + I  FH AQ    + +  + G   + + RP+  
Sbjct: 60  RVPPEAMEAAFRALRAEVREALARAAERIRRFHEAQLPNDIVIRGEDGETLEMLWRPLHR 119

Query: 127 VGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPI----ADEILYAAQLCGVQDVF 182
           VG+Y PGG A   STVLM   PA +AG + + L SPP         +L AA L GV++++
Sbjct: 120 VGVYAPGGRAAYPSTVLMDVIPAQVAGVRSIALVSPPGPDGLPHPAVLAAAHLVGVEEMY 179

Query: 183 NVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVI 242
            VGGAQA+AALA+GTE++ +VDKI GPGN +V  AKR V   +    ID  AGP+EV+V+
Sbjct: 180 AVGGAQAVAALAYGTETIARVDKIVGPGNVYVATAKRMVMGDV---GIDSIAGPTEVVVV 236

Query: 243 ADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL 302
           AD  A P +VA+DLL+QAEH  ++  + L+P+ ++   V   + RQLA LPR + AR+AL
Sbjct: 237 ADETANPAYVAADLLAQAEHDVEAGAVCLSPSRELLENVHAEIVRQLAALPRRDIAREAL 296

Query: 303 N-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDY 361
                L+  K L   V + N   PEH+ + T N R +++ + +AG+VFLG ++PE  GDY
Sbjct: 297 ERHGALVHVKSLDDAVVLVNDMAPEHVEVVTENPRRVLNGLRTAGAVFLGPYTPEPVGDY 356

Query: 362 ASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKN 421
            +GTNHVLPT+G     S LG  DF +RMT    + E  +  A  IE LA AE LTAH+ 
Sbjct: 357 FAGTNHVLPTHGSARFSSGLGTLDFMRRMTAATYTAETIARHAPYIEALAEAESLTAHRE 416

Query: 422 AVTLRVNALK 431
           AV +R   L+
Sbjct: 417 AVRIRREELR 426


>UniRef50_P62460 Histidinol dehydrogenase n=15 Tax=Bacteria RepID=HISX_THET2
          Length = 412

 Score =  511 bits (1316), Expect = e-143,   Method: Composition-based stats.
 Identities = 172/414 (41%), Positives = 241/414 (58%), Gaps = 6/414 (1%)

Query: 14  AEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEI 73
           AE+ R    R  +S   ++   V  IL+ V+  GDEAL  +S   D   V   +V     
Sbjct: 5   AEEVRARFARRGLSFDPTVEEIVRGILEAVREEGDEALDRFSRDLDGYPVE--EVPKRAW 62

Query: 74  AAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPG 133
             A E L ++L+ A+  A + IE F+  +      +  + G    Q+ RP+  VG+Y+PG
Sbjct: 63  REAYEDLDEDLRDALETARERIEAFYREEARGGF-LRAEGGGVLAQLVRPLERVGVYVPG 121

Query: 134 GSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVFNVGGAQAIAAL 193
           GSAPL ST+LM   PA +AG ++V++ SPP +   +L AA + G   +F +GGAQAIAAL
Sbjct: 122 GSAPLLSTLLMTVVPAKVAGVREVIVASPPKVHPGVLAAAWVAGADRLFAMGGAQAIAAL 181

Query: 194 AFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVA 253
           A+GT  VP+VDKI GPGN +V  AKR V   +    ID  AGP+E ++IAD  A+P  +A
Sbjct: 182 AYGTGRVPRVDKIVGPGNRYVVAAKRLVYGTV---GIDGLAGPTETMIIADGSASPRLLA 238

Query: 254 SDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDL 313
           +DLL+QAEHGPDS+  LL+P   +  RV   + RQL +LPRAE ARQAL    L++TKDL
Sbjct: 239 ADLLAQAEHGPDSEPWLLSPDRALLERVEAELSRQLQDLPRAEVARQALEKGGLVLTKDL 298

Query: 314 AQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYG 373
            +   ++N Y PEHL +   +    ++ + +AG VFLG+ SPE+ GDY +G +HV+PT G
Sbjct: 299 EEAFALANLYAPEHLSLALSDPLPWLEKVQNAGGVFLGEGSPEALGDYIAGPSHVMPTSG 358

Query: 374 YTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRV 427
                  L + DF K + V  LS+     LA     LA AE L  H  ++ LR 
Sbjct: 359 TARFQGGLAVRDFLKVIPVVGLSEGAARELAKKGALLARAEGLEGHARSLDLRR 412


>UniRef50_Q4FNE2 Histidinol dehydrogenase 1 n=3 Tax=Candidatus Pelagibacter
           RepID=HISX1_PELUB
          Length = 428

 Score =  507 bits (1306), Expect = e-142,   Method: Composition-based stats.
 Identities = 144/431 (33%), Positives = 244/431 (56%), Gaps = 8/431 (1%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              I+D  +   ++    L+    +  +  + +V  I+ +VK  GD+A+ +Y  +F+K +
Sbjct: 1   MIKILDSKNKNFDKTLDALLSKRKNKVQLNSVSVIKIIKDVKKNGDKAILKYEKRFNKNS 60

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
           +  +  S ++I  A + L  ++K+A+ +A   I  FH+ QK   +    +   + +    
Sbjct: 61  I--IAPSIKQINRAIQSLDQKVKKAIDLAYDRIYKFHSLQKFKNISYTDKLKNKLEYKYV 118

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPI---ADEILYAAQLCGVQ 179
           P+ SV +Y+PG +A   S+VLM A PA +AG K++V+ +P         +LYAA+ C ++
Sbjct: 119 PIESVAIYVPGSTASYPSSVLMNAVPAIVAGVKRLVMVNPGQKGKQNPAVLYAAKKCKIK 178

Query: 180 DVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEV 239
           +++++GG  AIAA+A+GT+ + KVDKI GPGN++V  AK++V   +      M AGPSEV
Sbjct: 179 EIYSIGGPSAIAAVAYGTKKIKKVDKIIGPGNSYVAAAKKEVFGDVGIEG--MIAGPSEV 236

Query: 240 LVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETAR 299
            ++ D  + P+++ASDL+ QAEH   +Q IL++    + ++V   +  QL ELPRA  A+
Sbjct: 237 TIVCDKFSNPEWIASDLIGQAEHDNLAQCILISKDKSIIKKVNYEIINQLKELPRAVIAK 296

Query: 300 QAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESA 358
            +L N   LI      + +   N+  PEHL + T+N +++V  I +AGS+ LG ++  + 
Sbjct: 297 NSLLNNGILIYMPSDQKIINTVNKIAPEHLELNTKNYKKVVSKIKNAGSICLGKYAVMAM 356

Query: 359 GDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTA 418
            DY  G+NHVLPT       S + + +F KR++   LSK+G   L  ++ TLA  E L  
Sbjct: 357 TDYNVGSNHVLPTNSSARYSSGVSVNEFYKRISYINLSKKGIETLGPSVITLANYEGLVG 416

Query: 419 HKNAVTLRVNA 429
           H  +V  R+  
Sbjct: 417 HAKSVEKRIRR 427


>UniRef50_D0LM64 Histidinol dehydrogenase n=2 Tax=Nannocystineae RepID=D0LM64_HALO1
          Length = 438

 Score =  506 bits (1304), Expect = e-142,   Method: Composition-based stats.
 Identities = 181/440 (41%), Positives = 256/440 (58%), Gaps = 12/440 (2%)

Query: 1   MSFNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDK 60
           M    I       + + R LL R + S +  + R V DIL  V+ARGDEA+R ++ KFD 
Sbjct: 1   MILKRIPLDAGGDSRELRALLER-STSFASEVERAVADILAEVRARGDEAVRAFTEKFDG 59

Query: 61  TTV---TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVE---TQPG 114
            +    ++ ++   +   A   L+ E+  A+  A + +  FH  Q       +      G
Sbjct: 60  RSPRAGSSYEIPPGDWRRAKGELAPEVLAALEQAAERVRAFHARQAEVDRAADFSLDGGG 119

Query: 115 VRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQ 174
           +R      P++ VG+Y+PGG+A   S+VLM A PA IAG  ++++ +P   + E L AA 
Sbjct: 120 MRLDLRIDPLSRVGIYVPGGTARYPSSVLMTAIPARIAGVDEIIMVTP-GASKETLAAAA 178

Query: 175 LCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPA 234
           L GV  VF +GGAQA+AALA+GTESVP+VDKI GPGN +V  AKRQV   +D   ID  A
Sbjct: 179 LAGVDRVFEIGGAQAVAALAYGTESVPRVDKIVGPGNQWVAAAKRQVFGVVD---IDSVA 235

Query: 235 GPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPR 294
           GPSEVL++AD  A P +VA+DLL+QAEH P +  +L T +  +A  V E + RQLA+LPR
Sbjct: 236 GPSEVLILADDSANPRWVAADLLAQAEHDPLAHPVLATTSPALADAVDEELARQLADLPR 295

Query: 295 AETARQALNA-SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDW 353
           A+ AR AL      ++  D    V  +N+Y PEHL +  R  R ++  + +AG++F+G  
Sbjct: 296 ADIARTALANQGAAVLVPDQGAAVAFANRYAPEHLELHLREPRAVLGQLRTAGAIFVGAL 355

Query: 354 SPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAA 413
           + E+AGDY +G NHVLPT G     S LG+ DF+K  ++ E   E   A A  I  LAA 
Sbjct: 356 AAEAAGDYMAGPNHVLPTGGAARYASPLGVYDFRKHTSIIEYQAEAVLAQADAIAALAAV 415

Query: 414 ERLTAHKNAVTLRVNALKEQ 433
           E L AH  ++TLR +AL+  
Sbjct: 416 EGLDAHGRSMTLRRDALRAA 435


>UniRef50_Q4A044 Histidinol dehydrogenase n=62 Tax=Staphylococcus RepID=HISX_STAS1
          Length = 423

 Score =  506 bits (1304), Expect = e-142,   Method: Composition-based stats.
 Identities = 142/408 (34%), Positives = 234/408 (57%), Gaps = 11/408 (2%)

Query: 26  ISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELK 85
            S +E +   V DI +NV+  GD+ALR Y+ +FD+     L+V+ + +  A  RL  +L+
Sbjct: 16  SSLNEDLYPIVKDICENVRLHGDDALRNYNQQFDQVETCNLEVAYQTLENAYNRLDSDLR 75

Query: 86  QAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLML 145
           +A+  +   I+++  + K      + Q    C ++  P+  VG+Y+PGG A   STVLM 
Sbjct: 76  EALQQSHARIQSYQESIK----WTKQQGTSDCYELYHPLERVGVYVPGGKASYPSTVLMT 131

Query: 146 ATPASIAGCKKVVLCSPP---PIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPK 202
            T A +AG K + + +PP    I D +L A  + GV +V+ VGGAQ+IAALA+GTE++PK
Sbjct: 132 VTLAKVAGVKNISVVTPPQLNGIPDIVLAACYIAGVDNVYQVGGAQSIAALAYGTETLPK 191

Query: 203 VDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEH 262
           VDKI GPGN FV  AK+ +  ++    ID  AGPSE+ +I D  A  D +A D+ +QAEH
Sbjct: 192 VDKIVGPGNQFVAYAKKYLFGQV---GIDQIAGPSEIALIIDDSADLDAIAYDVFAQAEH 248

Query: 263 GPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVEISN 321
              ++  +++    + +++ + ++  L ++ R    + +L +   LI   + ++  ++ N
Sbjct: 249 DELARTFVISEDEALLKQLEQKIQHILPQIERQSIVQASLNDNHFLIHVNNFSEACDLMN 308

Query: 322 QYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSL 381
           Q  PEH  IQT +  + ++ +   G++FLG +SPE  GDY +G +HVLPT       + L
Sbjct: 309 QIAPEHASIQTVSPHDYLNHVRYVGALFLGYYSPEVIGDYVAGPSHVLPTNQTARFTNGL 368

Query: 382 GLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNA 429
            + DF  R +V +LSK+ F  +  T   LA  E+L  H+ ++ +R + 
Sbjct: 369 SVNDFLTRHSVIDLSKDTFDTVELTARKLAHVEQLYNHEQSIEIRTSK 416


>UniRef50_C9RN89 Histidinol dehydrogenase n=1 Tax=Fibrobacter succinogenes subsp.
           succinogenes S85 RepID=C9RN89_FIBSS
          Length = 429

 Score =  506 bits (1304), Expect = e-142,   Method: Composition-based stats.
 Identities = 165/434 (38%), Positives = 241/434 (55%), Gaps = 15/434 (3%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
             I+     + ++  ++  R  ++ S+ I   V DIL ++K  G     EY+ KFD    
Sbjct: 1   MKIVKVTPKS-QEIDRICGR-EVAPSKEIHDKVMDILADIKNGGYAKAVEYAQKFDGLKG 58

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRP 123
             L+VS  EI  ++ +   E+++A+  A+KN+  FH  Q      +E + GV   Q  RP
Sbjct: 59  KNLRVSEAEIKKSAAKCPPEMQRALKQAIKNVRDFHVNQMEDSWLMEGKDGVVLGQRIRP 118

Query: 124 VASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSP--PPIADEILYAAQLCGVQDV 181
           +  VGLY+PGG+    STV+M A PA +AG K +V+ +P    I   + +     G+ +V
Sbjct: 119 MKRVGLYVPGGAGIYPSTVIMNAVPAIVAGVKDIVVVTPIKGEINRAVAFVLCELGITEV 178

Query: 182 FNVGGAQAIAALAFGTES------VPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAG 235
           +++GGAQAI  LA+G +       V +VDKI GPGN F   AK++V   +D   IDM AG
Sbjct: 179 YHIGGAQAIGMLAYGAKDGKGKVVVERVDKIVGPGNVFAAVAKKEVFGIVD---IDMVAG 235

Query: 236 PSEVLVIADSGATPDFVASDLLSQAEHGPD-SQVILLTPAADMARRVAEAVERQLAELPR 294
           PSEVLV+AD+   PDFVA+DLLSQAEHG      I +T   + A+ ++E V+ Q+   P+
Sbjct: 236 PSEVLVLADNTCDPDFVAADLLSQAEHGSGFEAAICITDNMETAQMISECVDIQVENSPK 295

Query: 295 AETARQALNA-SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDW 353
            E  ++ L+   R++V KD    V I+N   PEH+ I T  A  +   I +AG+VF+G W
Sbjct: 296 RELLQKVLDNFGRILVVKDWFDGVAIANAIAPEHMEIMTDEAESMAAQIENAGAVFIGPW 355

Query: 354 SPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAA 413
           S E  GDY +G NHVLPT G     S LG+ DF KRM++ + S++     A  I  +A  
Sbjct: 356 SSEPVGDYFAGPNHVLPTNGTGRFFSPLGVYDFLKRMSIIKYSEKAIKKNAKAIAVVANE 415

Query: 414 ERLTAHKNAVTLRV 427
           E    H  AV  R+
Sbjct: 416 EGFIHHAAAVLKRL 429


>UniRef50_Q01ZU1 Histidinol dehydrogenase n=1 Tax=Candidatus Solibacter usitatus
           Ellin6076 RepID=Q01ZU1_SOLUE
          Length = 423

 Score =  503 bits (1297), Expect = e-141,   Method: Composition-based stats.
 Identities = 168/428 (39%), Positives = 248/428 (57%), Gaps = 15/428 (3%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              I++           LL R A   +E+    V  IL+ V+ RGD AL +Y+ +FD+  
Sbjct: 1   MIRILESKDVG-----HLLKRKAARFTEA-EAVVTPILEAVRKRGDRALMDYARQFDQLQ 54

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
             +++V   E+ AA + L+ E + A+  A  NI  +   Q     +     G++  Q+ R
Sbjct: 55  RKSVRVPEGELLAARDGLTPEFRGAIETAAPNIRAYAGRQMPREWNRSFGAGLQLGQLVR 114

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVF 182
           P+ +V  YIP G  PL STV+M   PA +AG   + +  P P+A E+   A + GV++VF
Sbjct: 115 PLDAVAAYIPAGRYPLPSTVMMTVIPAQVAGVPNICIACPKPVA-EVYGTAAMLGVRNVF 173

Query: 183 NVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVI 242
            +GGAQAIAA AFGT +VP+ D+I GPGN +V  AK+ ++  +    ID  AGP+E+L+I
Sbjct: 174 QMGGAQAIAAFAFGTRTVPRADRIVGPGNIYVAAAKKLLAGEV---GIDFIAGPTEILII 230

Query: 243 ADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL 302
           A +   P   A+D+L+QAEH  D+  ILLT +  +A  V+  +ERQLA LP A  A +++
Sbjct: 231 A-ADGDPRHFAADMLAQAEHDVDASAILLTTSKRLAAAVSRELERQLAILPTAPVASKSI 289

Query: 303 -NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDY 361
              S +I+ + L + +EISN++ PEHL I       L+  +  AGSVF+G +SPE+AGDY
Sbjct: 290 AKNSAIILVRSLDEALEISNRFAPEHLSIPDA---SLLPGVRHAGSVFVGPYSPEAAGDY 346

Query: 362 ASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKN 421
           ASG NHVLPT G       L + D+ K ++VQ L++     LA +I TLA AE L AH  
Sbjct: 347 ASGPNHVLPTSGAARQRGGLSVTDYVKVISVQNLTEPALRRLAPSITTLARAEGLEAHAR 406

Query: 422 AVTLRVNA 429
           +V +R+  
Sbjct: 407 SVEVRLTR 414


>UniRef50_B1YL14 Histidinol dehydrogenase n=1 Tax=Exiguobacterium sibiricum 255-15
           RepID=B1YL14_EXIS2
          Length = 405

 Score =  501 bits (1291), Expect = e-140,   Method: Composition-based stats.
 Identities = 161/401 (40%), Positives = 235/401 (58%), Gaps = 6/401 (1%)

Query: 27  SASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQ 86
           S      + V  IL+ V   GD A+R Y+++FD+  +T  ++   +I  A ++    L  
Sbjct: 8   SVDRETEQAVRSILEQVANDGDAAVRRYTSEFDRVDLTDFRLDETKIQEAFDQADPNLVD 67

Query: 87  AMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLA 146
           ++ +    +  +H  +    +++     V  +Q   PV SVG+Y+PGG+A   STVLM A
Sbjct: 68  SLKLMATRLVEWHEQELPSDIELVEAD-VTRRQRFVPVDSVGIYVPGGAASYPSTVLMNA 126

Query: 147 TPASIAGCKKVVLCSP-PPIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDK 205
            PA +AG ++VV+ +P   ++ E+L AA++ GV +++ +GGAQA+AAL FGTES+  VD 
Sbjct: 127 IPAKVAGVERVVMVTPVTGLSMEVLVAAKIAGVTEIYTIGGAQAVAALTFGTESIQAVDL 186

Query: 206 IFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPD 265
           I GPGN FV EAKRQV   +    ID  AGPSEV+VIAD  A PD +A+DLL+QAEH  D
Sbjct: 187 IVGPGNRFVAEAKRQVYGIV---GIDSVAGPSEVVVIADETAHPDRIAADLLAQAEHDRD 243

Query: 266 SQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQCVEISNQYGP 325
           +  I   P   M   V   +ER+L +LPR E AR+A+    + V   L   +E +N+   
Sbjct: 244 AVAIAFVPTEAMKADVDANIERRLQQLPRQEIARRAMENGGVFVA-SLDDAIEEANRLAA 302

Query: 326 EHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLAD 385
           EHL +   N +E+V  I  AG +FLG  +PE+ GDY +GTNHVLPT G     S L    
Sbjct: 303 EHLELAVANPQEVVKLIRHAGMIFLGHETPETLGDYVAGTNHVLPTSGTARFASGLSART 362

Query: 386 FQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLR 426
           F +  T+ E ++EG + LA+  +T+A  E L AH  A+ +R
Sbjct: 363 FLRHQTMLEATREGVARLANAAKTVARVEGLEAHAQAIEVR 403


>UniRef50_UPI00016BFCCC histidinol dehydrogenase n=1 Tax=Epulopiscium sp. 'N.t. morphotype
           B' RepID=UPI00016BFCCC
          Length = 419

 Score =  498 bits (1282), Expect = e-139,   Method: Composition-based stats.
 Identities = 173/431 (40%), Positives = 246/431 (57%), Gaps = 17/431 (3%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              I+D N+         +++ +   S  I R   +I++ VK  GD+AL +Y+ KFD+  
Sbjct: 1   MIKIVDKNTE--------ILKHSAEISPQIERDAQEIVETVKRLGDQALFDYALKFDRAQ 52

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
           +T+L VS +E+  A E + D+L   +  A KNIE FH  Q      VE + G+   Q   
Sbjct: 53  LTSLLVSEQELKDAYEXIDDDLLGVIRRAKKNIEDFHKRQITNSFMVE-KDGIIMGQRVT 111

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGV 178
           P+  VG+YIPGG A   S+VLM   PA +AGC  + + +PP     +A EIL    + GV
Sbjct: 112 PIERVGIYIPGGXAVYPSSVLMNVIPAKLAGCSYISVVTPPREDGTVAKEILAICAMLGV 171

Query: 179 QDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSE 238
             VF +GGA AIAALA+GTESV  V KI GPGNA+V  AK+ V  ++    IDM AGPSE
Sbjct: 172 DQVFKIGGAGAIAALAYGTESVLPVYKITGPGNAYVAAAKKAVFGKV---GIDMIAGPSE 228

Query: 239 VLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETA 298
           +L+IAD    P  +A+D+LSQAEH   ++ ILLT + ++A  VA  +E QL++LP+ + A
Sbjct: 229 ILIIADEKQXPKIIAADMLSQAEHDMLARAILLTTSKEIAEEVATEIEIQLSKLPKEKIA 288

Query: 299 RQALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPES 357
           R +++    ++V   L++C  ISN   PEHL I   NA   +  I +AGSVFLG ++PE+
Sbjct: 289 RPSIDDNGLIVVCDTLSECFAISNDLAPEHLEIMLDNAISYLPEIKNAGSVFLGRYTPEA 348

Query: 358 AGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLT 417
            GDY +G NH LPT   +   S+L +  F K+ T  + ++E        I   A  E L 
Sbjct: 349 VGDYYAGVNHTLPTNQTSKFSSALSVDTFVKKSTFVQYTEEMLQKYKDDIVLFAKHEGLD 408

Query: 418 AHKNAVTLRVN 428
           AH  +V  R  
Sbjct: 409 AHARSVQSRFQ 419


>UniRef50_Q5WIU9 Histidinol dehydrogenase 1 n=52 Tax=cellular organisms
           RepID=HISX1_BACSK
          Length = 424

 Score =  496 bits (1279), Expect = e-139,   Method: Composition-based stats.
 Identities = 147/413 (35%), Positives = 219/413 (53%), Gaps = 9/413 (2%)

Query: 26  ISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELK 85
             +   + +TV  ++  ++  G+ A+RE S +FD       ++SAEEI      + D++K
Sbjct: 15  KDSHGKVEQTVASLIARIEKEGETAVRELSRQFDNWDPEQFRLSAEEIEKIVRSVPDQVK 74

Query: 86  QAMAVAVKNIETFHTAQKL--PPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVL 143
             +  A + I  F   Q+     ++VET+PGV       PV SVG YIPGG  P+ ++  
Sbjct: 75  ADICFAQEQIRHFAEQQRASIQDIEVETRPGVFLGHKNIPVNSVGCYIPGGRYPMVASSH 134

Query: 144 MLATPASIAGCKKVVLCSPP---PIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESV 200
           M    A +AG K+V+ C+PP    I    + A    G  +++ +GG QA+ A+A GTE++
Sbjct: 135 MSILTAKVAGVKRVIGCTPPINGEIPAATVTAMHFAGADEIYILGGVQAMTAMAVGTETI 194

Query: 201 PKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQA 260
             VD + GPGNAFV EAKRQ+  R+    ID+ AGP+EVL+IAD  A  + VA+DLL QA
Sbjct: 195 EAVDMLVGPGNAFVAEAKRQLFGRV---GIDLFAGPTEVLIIADDTADGEMVATDLLGQA 251

Query: 261 EHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALN-ASRLIVTKDLAQCVEI 319
           EHGP S   L+T +  +A      +ERQL  LP A+ A+ A      +I+  DLA+ V  
Sbjct: 252 EHGPTSPAALITTSKKLAEETVAEIERQLQTLPTADVAKVAWEEHGMIILVDDLAEAVVE 311

Query: 320 SNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCS 379
           +++   EH+ + T N    +D +T+ G++FLG  +  + GD   GTNH LPT        
Sbjct: 312 ADKLAYEHVQVLTENPNYFLDHMTNYGALFLGPETNVAYGDKVIGTNHTLPTKKAAKYTG 371

Query: 380 SLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNALKE 432
            L +  F K  T Q  + E  + +    E L   E    HK   +LRV    +
Sbjct: 372 GLWVGKFLKNCTYQRCTPEASAEIGRIAERLCELEGFIGHKAQASLRVKRYGK 424


>UniRef50_C4L171 Histidinol dehydrogenase n=1 Tax=Exiguobacterium sp. AT1b
           RepID=C4L171_EXISA
          Length = 405

 Score =  496 bits (1278), Expect = e-139,   Method: Composition-based stats.
 Identities = 148/405 (36%), Positives = 237/405 (58%), Gaps = 14/405 (3%)

Query: 30  ESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLS-DELKQAM 88
           E+    V  I+++++ARGDEAL +++ +FD       ++ + ++A+ +  ++  EL +A+
Sbjct: 11  EAWAEAVKPIVESIEARGDEALLKWTKQFDGVD----RIESVDLASFNPPVAYAELTEAL 66

Query: 89  AVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATP 148
           ++A + I TFH  Q       E     R  +   P+ SVG+Y+PGG+A   S+VLM   P
Sbjct: 67  SLAAERIRTFHARQVRQDDVFEDTM-FRLGRRYMPLDSVGVYVPGGTAVYPSSVLMNIIP 125

Query: 149 ASIAGCKKVVLCSPPP---IADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDK 205
           A +AG K+VV+ +PP    I   +L AA++ G  + F +GGAQA+AALA+GTE++  VDK
Sbjct: 126 AKVAGVKRVVMVTPPKADGIDISLLIAAKIAGADECFLIGGAQAVAALAYGTETIRPVDK 185

Query: 206 IFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPD 265
           I GPGNA+V  AK  VS  +    ID  AGPSEVL+IAD  A P +VA+DLL+QAEH  +
Sbjct: 186 IVGPGNAYVATAKALVSHIV---GIDSVAGPSEVLIIADETANPKWVAADLLAQAEHDVE 242

Query: 266 SQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQCVEISNQYGP 325
           +  I +  +  +  ++ + +ERQL +LPR + AR++L     ++ + +   +E +N    
Sbjct: 243 ATAIAIVTSETLRDQIEQELERQLVQLPRQDIARESLKRGG-VLYRTIEDAIEYANTMAA 301

Query: 326 EHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLAD 385
           EH+ +  ++   L+ +I   GS FLG  + E+ GDY +G NHVLPT G     S L + D
Sbjct: 302 EHVQLAVKDPEVLMRAIRHGGSFFLGHEAAEAFGDYIAGPNHVLPTSGTARFSSGLSVDD 361

Query: 386 FQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNAL 430
           F +R T  E+++     +      +A  E+L  H  A+ +R+  +
Sbjct: 362 FYRRQTFLEMTELD-ETITKAAIRIAKQEQLEGHARAMAVRMEDV 405


>UniRef50_Q67KH6 Histidinol dehydrogenase n=1 Tax=Symbiobacterium thermophilum
           RepID=HISX_SYMTH
          Length = 439

 Score =  495 bits (1274), Expect = e-138,   Method: Composition-based stats.
 Identities = 163/430 (37%), Positives = 234/430 (54%), Gaps = 12/430 (2%)

Query: 13  TAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA--LKVSA 70
             +   + L R        I   V  IL+ V+  GD AL  ++ +FD   + A  L+V+ 
Sbjct: 6   EPQAFLEFLNRRRTEFYPEIEAQVRAILERVRREGDGALYAFTRQFDGADLEATGLRVTE 65

Query: 71  EEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLY 130
            E   A   +S   + A+ VAV+NI  FH  Q           G    Q   PV   G+Y
Sbjct: 66  AEYREAEAAVSAAFRAALQVAVENIAAFHRPQVPTSWFTTRPDGTIVGQRVTPVDRAGVY 125

Query: 131 IPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQDVFNVGG 186
           +PGGSAPLFS +LM A PA +AG  +V++C+PP     I   +L AA+  GV+DV+ VGG
Sbjct: 126 VPGGSAPLFSCLLMTAIPAVVAGVPEVIVCTPPDRNGRIDPHMLVAARAAGVKDVYKVGG 185

Query: 187 AQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSG 246
           AQAI A+A+GT +VP+VDKI GPGN +VT AK+ V   +    IDM AGP+EV+ + D  
Sbjct: 186 AQAIGAMAYGTATVPRVDKIAGPGNYYVTLAKKLVFGPV---GIDMLAGPTEVMAVDDGS 242

Query: 247 ATPDFVASDLLSQAEHGPDSQVILLTPA-ADMARRVAEAVERQLAELPRAETARQAL-NA 304
              +++A+DLLSQAEH P+  VIL+T A  +    V  A+ R  A LPRAET R+++   
Sbjct: 243 VDAEWLAADLLSQAEH-PNGMVILVTTAGPERIAAVGAAMARHTAALPRAETIRRSVAEL 301

Query: 305 SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASG 364
              +    L +  ++ N  GPEHL +   +    +  +  AGS+FLG W+PE+ GDY +G
Sbjct: 302 GAALAVDTLEEAADLVNAVGPEHLEVGVADPWAFLPLVRHAGSIFLGRWTPEAMGDYIAG 361

Query: 365 TNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVT 424
            ++V+PT G     S + +  F KR  V   S+  F A A     LA  E L AH  ++ 
Sbjct: 362 PSNVIPTEGTARYASPVCVETFIKRSAVTCYSEAAFRAQAPHAVRLALTEDLLAHAASMQ 421

Query: 425 LRVNALKEQA 434
           +R+     ++
Sbjct: 422 IRLAKPDGES 431


>UniRef50_B1H0F0 Histidinol dehydrogenase n=1 Tax=uncultured Termite group 1
           bacterium phylotype Rs-D17 RepID=B1H0F0_UNCTG
          Length = 419

 Score =  493 bits (1269), Expect = e-138,   Method: Composition-based stats.
 Identities = 144/412 (34%), Positives = 236/412 (57%), Gaps = 22/412 (5%)

Query: 21  LMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA--LKVSAEEIAAASE 78
           +++     ++ I+  V+DI++++K  GDEA+ +Y  KFD   ++    +VS + I  A++
Sbjct: 9   IIKTNQMDAKQISIYVSDIIEDIKNNGDEAVFKYLKKFDNVDLSKKGYRVSQKVIDDAAK 68

Query: 79  RLSDELKQAMAVAVKNIETFHTAQKL--PPVDVETQPGVRCQQVTRPVASVGLYIPGGSA 136
           R+  +LK  +  +  NI  +H  ++          + G++  Q  RPV SVGLY+PGG  
Sbjct: 69  RIPKQLKNVIKSSYSNILAYHKYERSQIKKRWNYVKNGLKIGQFYRPVESVGLYVPGGRF 128

Query: 137 PLFSTVLMLATPASIAGCKKVVLCSPPP-IADEILYAAQLCGVQDVFNVGGAQAIAALAF 195
           P  STV+M A PA  AG K++V+ +PP  + D +L++A+LCG+++++ +GG  A+ ALA+
Sbjct: 129 PYPSTVIMTAVPAMAAGVKRIVMVTPPKNMNDAVLFSAKLCGIKEIYCIGGVMAVGALAY 188

Query: 196 GTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASD 255
           GT+++ KVD I GPGNA+V EAK+QV  R+    ID  AGP+EV +IAD     D+V +D
Sbjct: 189 GTKTLKKVDMIVGPGNAYVNEAKKQVFGRV---GIDSLAGPTEVAIIADKDVPTDYVVAD 245

Query: 256 LLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQ 315
           +++Q EH P ++  LL  +A     + + + ++  +  R E                L +
Sbjct: 246 VMAQVEHDPLAKTYLLCESAKKMSEIEKLLPKEALKQLRTELC-------------SLNK 292

Query: 316 CVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYT 375
            V+I N   PEHL +  +N + L+ ++ +AG+VF+G  +P ++GDY +G +HVLPT G  
Sbjct: 293 AVDIVNNIAPEHLELLVKNYQILLKNVRNAGAVFVGYQTPTASGDYWAGPSHVLPTNGSA 352

Query: 376 ATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRV 427
              S L +  F KR    E++K    A   TI   A AE +  HK +  +R 
Sbjct: 353 KFSSGLSVMTFLKRSAYIEMNKNNKKAYK-TIADFAQAENMQYHKKSAEVRY 403


>UniRef50_Q7UX39 Histidinol dehydrogenase n=6 Tax=Planctomycetaceae RepID=HISX_RHOBA
          Length = 460

 Score =  490 bits (1263), Expect = e-137,   Method: Composition-based stats.
 Identities = 152/402 (37%), Positives = 225/402 (55%), Gaps = 11/402 (2%)

Query: 34  RTVNDILDNVKARGDEALREYSAKFDKTTV--TALKVSAEEIAAASERLSDELKQAMAVA 91
             V  I  +V+++G EAL  Y+   D   +    L+V  E++ AA      +L + +   
Sbjct: 63  EVVETICKDVQSQGTEALLRYTKSLDGAELTADTLRVPEEDLKAAHAVADPKLIETIGRI 122

Query: 92  VKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASI 151
             NI TF +A     V +  +PGV   Q   P+  VG+ +PGG+A   STV+M A PA +
Sbjct: 123 RDNIATFQSAILHRDVTITPRPGVSLTQRYVPIPRVGICVPGGAAAYPSTVMMTAIPAQV 182

Query: 152 AGCKKVVLCSPPPI----ADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIF 207
           AG  ++ + +PP        ++L      G+++V+  GGAQA+AA+A+G +++P VDKI 
Sbjct: 183 AGVDEIAVVAPPTPFGAYNTDMLATCHELGIKEVYRCGGAQAVAAMAYGCDALPAVDKIV 242

Query: 208 GPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQ 267
           GPGN FV  AK+ V   +D   ID  AGPSEV+VIAD  A   FVASDLL+QAEH P S 
Sbjct: 243 GPGNLFVALAKKHVFGTVD---IDSFAGPSEVIVIADESANAAFVASDLLAQAEHSPGS- 298

Query: 268 VILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVEISNQYGPE 326
            IL+T    +   V   + RQL EL R + AR AL +   L++ +D     E+++ + PE
Sbjct: 299 AILITWDESLLTSVQAELSRQLGELERGDLARDALSDFGALVLARDADHACELTDSFAPE 358

Query: 327 HLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADF 386
           HL I+TR    L+  I  +G+ FLG  +P + GDYA+G +HVLPT G     + L    F
Sbjct: 359 HLQIETREPESLIAKIRHSGAAFLGHHTPVALGDYAAGPSHVLPTGGTCRWAAGLSANSF 418

Query: 387 QKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVN 428
            +  +V +  +   SA+A  + T+A  E LTAH  ++++R  
Sbjct: 419 LRSGSVTQFDQSALSAIAQDVITVAEKEGLTAHARSISIRTE 460


>UniRef50_B3T638 Histidinol dehydrogenase n=1 Tax=uncultured marine crenarchaeote
           HF4000_ANIW141N1 RepID=B3T638_9ARCH
          Length = 434

 Score =  490 bits (1262), Expect = e-137,   Method: Composition-based stats.
 Identities = 157/443 (35%), Positives = 242/443 (54%), Gaps = 26/443 (5%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              I+   +         +       SE   +TV  IL++V+  GD A+++Y  KF+   
Sbjct: 1   MIKILQVRNVD-----SFVEYRRQKTSEKDRKTVQAILNDVRKNGDSAVKKYERKFNGRK 55

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFH----TAQK--------LPPVDVE 110
            + L+VS +EI  A E           + ++  + +       QK          P    
Sbjct: 56  TSQLRVSNKEIGEAEELPDPTDNIWTKLYLQEWDLYWNLSGRKQKLRKGGFCYEKPYFWG 115

Query: 111 TQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIA 166
             P ++ ++   P+ SVG YIPGG A   S+V+M   PA IAG K++V+ SPP     I 
Sbjct: 116 GLP-LKTEKRFVPIPSVGCYIPGGQARYPSSVVMSVLPAKIAGVKRIVIVSPPGRDGKID 174

Query: 167 DEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLD 226
              + AA +CGV +++ VGGAQAI ALA+GT+S+PKVDKI GPG  FV+ AK  VS   +
Sbjct: 175 PLTISAAAMCGVTEIYKVGGAQAIGALAYGTKSIPKVDKIVGPGGKFVSIAKAIVS---E 231

Query: 227 GAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVE 286
             +IDM AGP+E+ ++AD+ + P+ VA DL+SQAEH  D+   ++T +  +A+++ +++E
Sbjct: 232 QTSIDMIAGPTELGIMADTSSDPELVALDLISQAEHSKDTMCFVITQSKIIAKQIQKSIE 291

Query: 287 RQLAELPRAETARQAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSA 345
           + +    R+   R++L     + V K+  + +E++N+  PEHL +  +NAR L   IT A
Sbjct: 292 KLIPGTERSSIIRESLTKNGFIAVCKNENEMIELANKIAPEHLELMVKNARSLSKKITGA 351

Query: 346 GSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALAS 405
           G + +G  +P SA DY  GTNH+LPT G+  T   L + DF K  T+ E  K    AL+S
Sbjct: 352 GLLLIGKNTPSSASDYILGTNHILPTNGFGRTRGGLSVLDFLKLQTIVESKKSTLKALSS 411

Query: 406 TIETLAAAERLTAHKNAVTLRVN 428
            ++ L  AE L  H  AV  R++
Sbjct: 412 DLKALTDAEGLPNHYKAVKRRLD 434


>UniRef50_Q8TXG3 Histidinol dehydrogenase n=1 Tax=Methanopyrus kandleri
           RepID=HISX_METKA
          Length = 431

 Score =  490 bits (1262), Expect = e-137,   Method: Composition-based stats.
 Identities = 168/414 (40%), Positives = 231/414 (55%), Gaps = 11/414 (2%)

Query: 25  AISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVT--ALKVSAEEIAAASERLSD 82
           +      +   V  I ++V  RGDEAL EY+ +FD   +    L+VS ++   A E + +
Sbjct: 19  SEMDVTEVLPDVERIFEDVVERGDEALLEYTERFDGVKLEAEDLRVSEDDFEVARELVDE 78

Query: 83  ELKQAMAVAVKNIETFHTAQKLP-PVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFST 141
              +A+  A   IE FH               G  C    RP+  VG Y+PGG A   ST
Sbjct: 79  RTVEALEEAAHRIEEFHRKTLPRVDRITFDVEGTECGLTLRPIPRVGCYVPGGRAAYPST 138

Query: 142 VLMLATPASIAGCKKVVLCSPP-----PIADEILYAAQLCGVQDVFNVGGAQAIAALAFG 196
            LM   PA +AGC++VV+C+PP       + E+L A ++ G   V+ VGGAQAIAALA G
Sbjct: 139 ALMTVIPARVAGCREVVVCTPPADNDVRASPEVLVAVEIAGADAVYRVGGAQAIAALAAG 198

Query: 197 TESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDL 256
           TE+V +VDKI GPGN +VT AK     R     +DMPAGPSEV VIAD  A PD++A DL
Sbjct: 199 TETVLRVDKIVGPGNVYVTAAKLLAYSR-GLTDVDMPAGPSEVFVIADDSANPDWLARDL 257

Query: 257 LSQAEHGPDSQVILLTPAADMARRVAEAVERQL-AELPRAETARQALN-ASRLIVTKDLA 314
           ++QAEH P +  +L T + ++AR V E VE  L A + R E   +AL+    ++V   L 
Sbjct: 258 IAQAEHDPHAAAVLATDSEEIARAVKERVEELLDAGIEREEIVLKALDRNGWIVVLDSLE 317

Query: 315 QCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGY 374
           +CV ++N+Y PEHL +   N  EL+  + +AG+VF+G  +    GDYA+G NHVLPT G+
Sbjct: 318 ECVRLANRYAPEHLQLCVENPEELLQDVENAGAVFVGHLTAVPFGDYATGPNHVLPTGGF 377

Query: 375 TATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVN 428
                +LG  DF K + +Q L +     LA  +E LA  E L  H  AV  R +
Sbjct: 378 ARARGALGTWDFVKIIPIQRLREGDVERLAPIVEELAEREGLPNHAEAVRARRS 431


>UniRef50_UPI00017455E1 Histidinol dehydrogenase n=1 Tax=Verrucomicrobium spinosum DSM 4136
           RepID=UPI00017455E1
          Length = 428

 Score =  489 bits (1260), Expect = e-137,   Method: Composition-based stats.
 Identities = 157/430 (36%), Positives = 239/430 (55%), Gaps = 11/430 (2%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
             I+ +           L R A ++   +   V  ++ +++  GD+AL E + KFD  T+
Sbjct: 1   MRILRYTDAAYADALCRLNRRAEASD-RVRDVVAAVIADIRQNGDKALLELTQKFDGATL 59

Query: 64  --TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVT 121
               L VS EE+AAA   L+ E++ A+  +++N+ TF          +  + G    +V 
Sbjct: 60  TAEQLVVSTEEVAAAVASLTPEVRAALDASLRNVTTFAHQSLRKDWSMINEQGAEVGEVY 119

Query: 122 RPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLC----G 177
            P   VG+Y+PGG+APL ST +M    A+ AG  ++V+CSP     ++           G
Sbjct: 120 HPFERVGVYVPGGTAPLVSTAIMTVAIAAAAGVPEIVVCSPCGKDGKVNANLLAALSLAG 179

Query: 178 VQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPS 237
             +++ VGG+QAIAA+AFGTE++  V KIFGPGN++V EAKRQV   +   ++D+  GPS
Sbjct: 180 ATEIYRVGGSQAIAAMAFGTETIKPVTKIFGPGNSYVVEAKRQVFGVV---SVDLLPGPS 236

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAET 297
           EV+V+ADS A P F+A+DLL+QAEHG DS V  LT    +   V   VE Q  +L R E 
Sbjct: 237 EVMVLADSSANPAFIAADLLAQAEHGKDSGVAFLTDDETLLNAVVSQVETQGQKLTRQEM 296

Query: 298 ARQALNAS-RLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPE 356
            R  L+    L++   L +  EI N Y PEHL + T    +++  I +AG++FLG++SP 
Sbjct: 297 VRSVLDKECFLMLVPTLEEGAEIVNNYAPEHLSLITAREHDILPLIRTAGAIFLGNYSPV 356

Query: 357 SAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERL 416
           + GD+ +G +H LPT G   +   L +  FQKR ++  LSKE  +     +   +  E L
Sbjct: 357 AVGDFLAGPSHTLPTGGAGKSFPGLTVDMFQKRTSIVRLSKEACAKSEPIVRVFSEIEGL 416

Query: 417 TAHKNAVTLR 426
            AH  +V++R
Sbjct: 417 DAHGLSVSVR 426


>UniRef50_A6UA68 Histidinol dehydrogenase n=4 Tax=Proteobacteria RepID=A6UA68_SINMW
          Length = 432

 Score =  489 bits (1260), Expect = e-137,   Method: Composition-based stats.
 Identities = 156/415 (37%), Positives = 225/415 (54%), Gaps = 6/415 (1%)

Query: 23  RPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSD 82
           R A+S +  + +TV +I+ NV+ RGD A+REYSA FDK  +   +VS EE   A   L  
Sbjct: 20  RDAVSDTAPVEKTVKEIIANVRERGDAAVREYSAAFDKVELEKFEVSQEERLKAVAELDP 79

Query: 83  ELKQAMAVAVKNIETFHTAQKLP--PVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFS 140
           + ++    A+ N+  F  AQ     P+++ET PG+       P+  VG Y+PGG  PL S
Sbjct: 80  QTREDTEFAIANVRAFAEAQLKTILPLEIETLPGLHLGHRVIPIEIVGCYVPGGRYPLLS 139

Query: 141 TVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESV 200
             +M   PA +AGC +V+ C PP     ++    L G   +F VGGAQAIAA+A GTE++
Sbjct: 140 APVMTIVPAKVAGCDQVIACLPPNAHPAMIAGCHLSGADRIFRVGGAQAIAAMASGTETI 199

Query: 201 PKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQA 260
           P VDKI GPGNAFV EAKRQV  ++    ID  AGPSE+ ++AD       +A+DLL+QA
Sbjct: 200 PAVDKIVGPGNAFVNEAKRQVFGQV---GIDQLAGPSEIFIVADETGKAAMIATDLLAQA 256

Query: 261 EHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVEI 319
           EH   ++V L+T    +A      VE+QL +L  A  A  A  +   + V +D    +  
Sbjct: 257 EHDVRTRVGLITTDRKLAEETLVEVEKQLQDLSTANVASVAWKDYGEITVCEDETTMIAY 316

Query: 320 SNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCS 379
           S+    EHL + TR+ +     + + GS+F+G+ +     D   GTNH LPT        
Sbjct: 317 SDYIAAEHLQVHTRDPQATARKLRNYGSLFIGELASVVYSDKCCGTNHTLPTMAAGRYTG 376

Query: 380 SLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNALKEQA 434
            L +  + K  T Q L + G +A+A      +A ERL  H+ A  LR++  +  A
Sbjct: 377 GLWVGSYLKTCTHQWLDERGVAAVAPAAVRQSATERLEGHRRAAALRLSPQQFAA 431


>UniRef50_D1N997 Histidinol dehydrogenase n=2 Tax=Lentisphaerae RepID=D1N997_9BACT
          Length = 431

 Score =  489 bits (1259), Expect = e-137,   Method: Composition-based stats.
 Identities = 170/436 (38%), Positives = 239/436 (54%), Gaps = 13/436 (2%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              +   ++      ++L  RP  S    I      I+ +VKA GD AL  Y+AKFD   
Sbjct: 1   MKKLYFGSADFEADLKKLYDRP--SYPPEIEAQAAAIIADVKAEGDAALVRYAAKFDHAE 58

Query: 63  VTA--LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQV 120
           +T    +V+ +EIAAA ++L   LK A+  A++ +  F             +PGV   + 
Sbjct: 59  LTPAQFRVTGDEIAAAEKQLPARLKSAIRTALRQVRDFAKLTIPKGWTASPRPGVTLGEK 118

Query: 121 TRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLC 176
             P+  VG+YIPGG+APL STVL  A  A  A  K++V  +PP     +   +LYA +L 
Sbjct: 119 FEPLDRVGVYIPGGTAPLVSTVLHTAGIAGAAKVKEIVAVTPPGRDGKVHPAVLYAMKLA 178

Query: 177 GVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGP 236
           GV +++ +GG   +AALA GTE++ KV+KI GPGNA+VT AK+ +  ++   AIDM AGP
Sbjct: 179 GVTEIYRLGGVYGVAALACGTETIAKVEKIVGPGNAYVTAAKKLLYGQV---AIDMVAGP 235

Query: 237 SEVLVIADSGATPDFVASDLLSQAEHGPD-SQVILLTPAADMARRVAEAVERQLAELPRA 295
           SE+LVIAD  A P F+A+DLLSQAEHG    Q +L+T    M  RV     RQ A LPR 
Sbjct: 236 SEILVIADETADPSFIAADLLSQAEHGSGLEQAVLVTTDKAMIDRVEAEFLRQKATLPRL 295

Query: 296 ETARQALNAS-RLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWS 354
            T  +       LI T DL     I++ Y PEHL IQT    ++   IT+AG++FLG W+
Sbjct: 296 ATVDRVQEHGLFLIHTPDLDTAAAIASSYAPEHLEIQTARPEQVARKITAAGAMFLGKWT 355

Query: 355 PESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAE 414
           PE  GD+ +G +HVLPT       + L    F +R ++ + ++       S +E  A  E
Sbjct: 356 PEPVGDFCAGPSHVLPTASSARYFNGLETVSFFRRSSIVKYTEAAIRREVSMVEAFAEME 415

Query: 415 RLTAHKNAVTLRVNAL 430
            L AH  + T+RV  L
Sbjct: 416 GLAAHGRSGTIRVKPL 431


>UniRef50_A1ZJE8 Histidinol dehydrogenase n=1 Tax=Microscilla marina ATCC 23134
           RepID=A1ZJE8_9SPHI
          Length = 429

 Score =  488 bits (1256), Expect = e-136,   Method: Composition-based stats.
 Identities = 168/435 (38%), Positives = 262/435 (60%), Gaps = 12/435 (2%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              II  +     + ++          E++ + V  IL  V+  GD+ALR +  K+D+  
Sbjct: 1   MEKIIYPHKEDWSKLQE----RTFETYEALEKAVRPILRRVQREGDKALRSFVFKYDRVR 56

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
           +   +++ EE+A AS  +SDELK+A+ VA  NI TFH  Q      +ET  GV   Q   
Sbjct: 57  IKRFQLTPEELAEASNHVSDELKEAINVAKYNIATFHLTQTKAVKKIETTEGVFSWQKNV 116

Query: 123 PVASVGLYIPG-GSAPLFSTVLMLATPASIAGCKKVVLCS----PPPIADEILYAAQLCG 177
           P+A VGLY+P  G APL+S +LM+   A+IAGCK+++LCS       I   ILY A L  
Sbjct: 117 PIAKVGLYVPSTGDAPLYSHILMMGILANIAGCKEIILCSAANHEGRIHPIILYTAHLLN 176

Query: 178 VQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPS 237
           ++ V+ VGG QAIAA+A+GTE++PKVDKIFGP N +V+ AK+ VS+  +  AIDMP GPS
Sbjct: 177 IKKVYRVGGVQAIAAMAYGTETIPKVDKIFGPSNEYVSTAKQLVSK--NDVAIDMPVGPS 234

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELP-RAE 296
           E+  +AD    P + A+D+L+ AE    +Q+++LT A ++A ++   V++QL ELP + E
Sbjct: 235 ELCYVADQSTNPVYAAADILAHAEQSSHNQLVVLTNAEEVADKIQAEVDKQLNELPLKKE 294

Query: 297 TARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPE 356
            A++    +++IV K   + +  +N+Y PE+L++   NA  + D IT+A S+ LG  +P 
Sbjct: 295 VAKEVFKNAKIIVFKSNVESIAFANEYAPENLVLAIDNAEAVGDRITNASSIHLGHLTPP 354

Query: 357 SAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERL 416
           + G YA+G NH+LP+ G+  + S L +  F K++  Q+++  G   + ST+ T++ AE L
Sbjct: 355 AVGYYAAGPNHILPSNGFARSYSGLSVDSFVKKINFQQVTPLGLQNVGSTVATMSEAEEL 414

Query: 417 TAHKNAVTLRVNALK 431
              KN++  R+  L 
Sbjct: 415 LGRKNSIIKRLELLD 429


>UniRef50_Q483H8 Histidinol dehydrogenase 2 n=15 Tax=Proteobacteria
           RepID=HISX2_COLP3
          Length = 446

 Score =  487 bits (1254), Expect = e-136,   Method: Composition-based stats.
 Identities = 150/441 (34%), Positives = 231/441 (52%), Gaps = 16/441 (3%)

Query: 5   TIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDK--TT 62
            I   +  +AEQ+ +LL R   +    I   V  I++NVK  GD+AL EY+ KFDK   +
Sbjct: 6   KIHRLSDLSAEQRNKLLQRTESNLDNFI-DIVKPIIENVKLNGDKALSEYAKKFDKAEVS 64

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPP-VDVETQPGVRCQQVT 121
              ++V+  E   A   + +E+ Q ++ ++ NI+ FH AQ        + +PG       
Sbjct: 65  TDQIQVTQAEFDEAFTLVDEEVIQTLSYSIDNIKKFHEAQMPEEMWMKQIRPGCYAGDRF 124

Query: 122 RPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCG 177
            P+ +V  YIP G     S  +M A PA +AG    ++ +PP     +    L  A+L G
Sbjct: 125 TPINAVACYIPRGKGSFPSVAIMTAVPAIVAGVPTAIIITPPGTDGKVDAATLVVAKLVG 184

Query: 178 VQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPS 237
           +  VF  GGAQ IAA+A+GT +VPK DK+ GPG+ FV  AK+ ++  +       PAGPS
Sbjct: 185 IDKVFKCGGAQGIAAVAYGTNTVPKCDKVVGPGSPFVVAAKKLLADIIHPGT---PAGPS 241

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPR--A 295
           E +V+AD  A P   A DLL +AEHGPDS   L+T + ++A +   A+      + R   
Sbjct: 242 EAIVLADDTANPKLAALDLLVEAEHGPDSSAFLVTNSKELAEQAQVAINEYWQHMDRLRV 301

Query: 296 ETARQAL--NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDW 353
           + +   L  +   +++T    + V+  N Y  EHL+I +++  + +  I +AG + LG+ 
Sbjct: 302 DFSSTVLSGDNGGIVLTSTFEEAVDFCNDYAAEHLLILSKSPFDHLGKIINAGEILLGEN 361

Query: 354 SPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAA 413
           +P S  +Y  G N VLPT     T S L + D+ K  ++  L++EG+  LA      A  
Sbjct: 362 TPISIANYTLGPNAVLPTSMAAKTASPLSVFDYLKSCSIGYLTREGYEELAPHTYRFAKY 421

Query: 414 ERLTAHKNAVT-LRVNALKEQ 433
           E   AH NAV+ LR  A+K +
Sbjct: 422 EGFDAHANAVSHLRDEAIKSE 442


>UniRef50_Q13I58 Histidinol dehydrogenase n=22 Tax=cellular organisms
           RepID=Q13I58_BURXL
          Length = 443

 Score =  486 bits (1252), Expect = e-136,   Method: Composition-based stats.
 Identities = 141/424 (33%), Positives = 211/424 (49%), Gaps = 10/424 (2%)

Query: 17  QRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAA 76
           +R         +   +   V  I+ +++ +GDEA+REYS KFD       ++S  EI  A
Sbjct: 10  KRGRTAAGKSDSDAKVRAIVESIIQHIEEKGDEAVREYSRKFDNWDPGDFRLSRPEIETA 69

Query: 77  SERLSDELKQAMAVAVKNIETFHTAQK--LPPVDVETQPGVRCQQVTRPVASVGLYIPGG 134
            ++LS    + +A A   +  F   Q+  +  V+ ET PGV       P+ +VG YIPGG
Sbjct: 70  RKQLSAREIEDIAFAQTQVRNFARIQRDSMRDVETETLPGVVLGHKHIPMNAVGCYIPGG 129

Query: 135 SAPLFSTVLMLATPASIAGCKKVVLCSPP---PIADEILYAAQLCGVQDVFNVGGAQAIA 191
             PL ++  M    A +AG  +VV  +PP        I+ A  + G  ++  +GG QA+ 
Sbjct: 130 KYPLLASAHMSVLTAKVAGVARVVSTAPPYQGKPHPAIVTAMDMAGADEILVLGGIQAVV 189

Query: 192 ALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDF 251
           A+A GT +V  VD + GPGN FV EAKRQ+  R+    ID+ AGP+E LVIAD     + 
Sbjct: 190 AMAVGTPTVAPVDMLVGPGNMFVAEAKRQLYGRV---GIDLFAGPTETLVIADESVDGEL 246

Query: 252 VASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVT 310
            A DLL QAEHG  S  ILLT +  +AR     +ERQL  LP A  A Q+  +   +IV 
Sbjct: 247 CAVDLLGQAEHGATSPSILLTNSEKLARDTLAEIERQLKILPTASIAAQSWADCGEVIVC 306

Query: 311 KDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLP 370
               + +++++    EH+ + T +    ++++T+ G++FLG  +  S GD   GTNH LP
Sbjct: 307 DTYEEMLQVADDIASEHVQVMTEDPDFFLNNMTNYGALFLGPRTNVSFGDKVIGTNHTLP 366

Query: 371 TYGYTATCSSLGLADFQKRMTVQEL-SKEGFSALASTIETLAAAERLTAHKNAVTLRVNA 429
           T         L +  F K  T Q + + E  + +      L   E    H     +RV  
Sbjct: 367 TNRSARYTGGLWVGKFLKTCTYQRVTTNEASAIIGEYCSRLCHMENFAGHGEQANIRVRR 426

Query: 430 LKEQ 433
              +
Sbjct: 427 YGNR 430


>UniRef50_C0G418 Histidinol dehydrogenase n=2 Tax=Rhizobiales RepID=C0G418_9RHIZ
          Length = 444

 Score =  486 bits (1251), Expect = e-136,   Method: Composition-based stats.
 Identities = 155/411 (37%), Positives = 218/411 (53%), Gaps = 14/411 (3%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
             T +       EQ+    +      SE + R V +I+D V+  GD AL +YS +FD+  
Sbjct: 1   MVTTLRQTDPDFEQKFAAFLSGKREVSEDVDRAVREIVDRVRREGDSALLDYSRRFDRID 60

Query: 63  VTA--LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQV 120
           +    + V+  EI AA +       +A+ +A   IE  H  Q           GV     
Sbjct: 61  LEKTGIAVTEAEIDAAFDAAPASTVEALKLARDRIEKHHARQLPKDDRYTDALGVELGSR 120

Query: 121 TRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCG 177
              + +VGLY+PGG+A   S+VLM A PA +AG  ++V+  P P   +   +L AA+L G
Sbjct: 121 WTAIEAVGLYVPGGTASYPSSVLMNAMPAKVAGVDRIVMVVPAPDGNLNPLVLVAARLAG 180

Query: 178 VQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPS 237
           V +++ VGGAQAIAALA+GTE++  V KI GPGNA+V  AKR V   +    IDM AGPS
Sbjct: 181 VSEIYRVGGAQAIAALAYGTETIRPVAKIVGPGNAYVAAAKRIVFGTV---GIDMIAGPS 237

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAET 297
           EVL++AD    PD++A+DLL+QAEH   +Q IL+T     A  V EAVERQL  L R ET
Sbjct: 238 EVLIVADKDNNPDWIAADLLAQAEHDTAAQSILMTNDEAFAHAVEEAVERQLHTLARTET 297

Query: 298 ARQAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPE 356
           A  +  +   +I+ KD    + ++N+   EHL I   +A   V  I +AGS+F+G ++P 
Sbjct: 298 ASASWRDFGAVILVKDFEDAIPLANRIAAEHLEIAVADAEAFVPRIRNAGSIFIGGYTPG 357

Query: 357 SAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQEL-SKEGFSALAST 406
           S      G   + P     A C  L L  F  R+    L S+ G  A + T
Sbjct: 358 SDRRLCGG---LQPCAANGALCPFL-LRPFGARLYEAHLASQAGLRAASRT 404


>UniRef50_P73058 Histidinol dehydrogenase 1 n=11 Tax=Cyanobacteria RepID=HISX1_SYNY3
          Length = 434

 Score =  481 bits (1238), Expect = e-134,   Method: Composition-based stats.
 Identities = 160/434 (36%), Positives = 247/434 (56%), Gaps = 14/434 (3%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFD--K 60
              I+  +  T +Q  QL  R   +  +++     ++++ VK  GD  +  YS +FD   
Sbjct: 1   MTRILKLSHLTPQQLNQLKRRSEQNIDQAL-AIAKEVIEQVKMEGDAGVLHYSRQFDFAG 59

Query: 61  TTVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDV-ETQPGVRCQQ 119
            T   L+VS  E A A + +  EL++A+  A +NIE  H  Q  PP+ + E +PGV   +
Sbjct: 60  ATAENLRVSEAEFAEAEKLVDPELRRAVEHAFRNIEKVHAGQMPPPMHLAEIEPGVFAGE 119

Query: 120 VTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQL 175
              P+ +VGLY+P G     S +LMLA PA +AG KK+V+C+PP     +    L  A++
Sbjct: 120 KITPLPTVGLYVPRGKGAFPSMMLMLAVPARVAGVKKIVVCTPPDKEGKVEPVSLVTARM 179

Query: 176 CGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAG 235
            GV +V+ +GG QA+AA+A+GT++V KVDK+ GP + +   AKR +S  +D   + +PAG
Sbjct: 180 AGVDEVYKLGGVQALAAIAYGTKTVSKVDKLIGPCSIYGAAAKRLLSGIVD---VGLPAG 236

Query: 236 PSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELP-- 293
           PSE +V+AD    P   A DLL +AEHG DS  +L+T +A +A +    +   L +LP  
Sbjct: 237 PSESIVLADETTDPKLAALDLLIEAEHGSDSAALLVTHSASLAEKALGYLGEYLEKLPPW 296

Query: 294 RAETARQAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGD 352
           R +     L +   +++T  L   ++  N Y PEHL + T +  +LV  I +AG + LG+
Sbjct: 297 RKKFCEDGLGSYGGILLTDSLQASLDFINDYAPEHLQVLTADPLKLVGKIDNAGEILLGN 356

Query: 353 WSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAA 412
           ++P SA  YA G N VLPT G+  + S++ + DF KR T+  L++EGF+ +  T+ TLA 
Sbjct: 357 YTPSSAATYAIGVNAVLPTGGFARSYSAVSVFDFLKRSTLAYLTEEGFAGVKETVTTLAD 416

Query: 413 AERLTAHKNAVTLR 426
            E   AH  A+  R
Sbjct: 417 YEDFPAHALAIRER 430


>UniRef50_Q4JW59 Histidinol dehydrogenase n=104 Tax=Actinobacteria (class)
           RepID=HISX_CORJK
          Length = 450

 Score =  480 bits (1237), Expect = e-134,   Method: Composition-based stats.
 Identities = 158/439 (35%), Positives = 233/439 (53%), Gaps = 15/439 (3%)

Query: 7   IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTAL 66
           +   + T  + R  L R       S+  TV  I+D V+  G  A  E   +FD  T  ++
Sbjct: 13  LRGQAPTTAELRHRLPRGGTDVD-SVIPTVAPIVDQVREGGARAALEIGQRFDGVTPDSV 71

Query: 67  KVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVAS 126
           +V AE I AA   L+D++  A+  A+K +  FH+A +     VE  PG    +   PV  
Sbjct: 72  RVPAEVIDAAVGTLADDVIAALEEAIKRVRAFHSAIRPEDKQVEVAPGGIVTERFIPVQR 131

Query: 127 VGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQDVF 182
           VGLY PGG+A   S+V+M   PA  AG + +V+ SPP         +L A +L GV +V+
Sbjct: 132 VGLYAPGGNAVYPSSVIMNVVPAQEAGVESLVVASPPQEGGWPHPTVLAACKLLGVDEVW 191

Query: 183 NVGGAQAIAALAFGT-----ESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPS 237
            VGGAQA+A LA G+     E +  VD + GPGN FVT AKR     +    ID  AGP+
Sbjct: 192 AVGGAQAVALLAHGSTAEGGEELEPVDMVTGPGNIFVTAAKRLCRSVV---GIDSEAGPT 248

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAET 297
           E+ V+AD  A    +A DL+SQAEH   +  +L+T +  +A  V   +  +      +E 
Sbjct: 249 EIAVLADESANAVEIAYDLISQAEHDTMAASVLITDSEKLADEVVAEMNERYHITENSER 308

Query: 298 ARQALN--ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSP 355
             +AL+   S +++  D+A  +  +N YG EHL I T +A  +   IT+AG++F+G +SP
Sbjct: 309 VAEALSGQQSGVVLVDDIAAGIRAANAYGAEHLEIHTEDAHGVAAQITNAGAIFIGRFSP 368

Query: 356 ESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAER 415
              GDYA+G+NHVLPT G     S L    F K + V + ++EG   +A T+ TL+ +E 
Sbjct: 369 VPLGDYAAGSNHVLPTSGTARHSSGLSTLTFLKSVHVIDYNEEGLRGVADTVITLSKSEG 428

Query: 416 LTAHKNAVTLRVNALKEQA 434
           L AH  A++ R +      
Sbjct: 429 LPAHGEAISARTSTANTNG 447


>UniRef50_D0XPF3 Histidinol dehydrogenase n=1 Tax=Brevundimonas subvibrioides ATCC
           15264 RepID=D0XPF3_9CAUL
          Length = 440

 Score =  480 bits (1235), Expect = e-134,   Method: Composition-based stats.
 Identities = 176/432 (40%), Positives = 251/432 (58%), Gaps = 9/432 (2%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
              IDW S   + +   L RP+  +   +   V+ I + V   G  A+ +++ + D    
Sbjct: 6   IKRIDWASLDGQGRFDALARPSRRSERDVQDVVSGIFEQVALSGGLAVTQFAERIDGFKP 65

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPV-DVETQPGVRCQQVTR 122
             + ++ E +AAA + L     +A+ VA +N+  FH A K      VET PGV+ + V R
Sbjct: 66  RRIAITPEAVAAARDALPPADTRALRVAAENVRVFHQATKPEDTAFVETTPGVKSKLVWR 125

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGV 178
           P+ + G+Y+PGG+APLFS++LM A PA +AG    V+ +PP     +   ++ AA    +
Sbjct: 126 PIGAAGIYVPGGTAPLFSSLLMQAIPAEVAGVTTRVVVTPPAKDGSVHPAMILAAAEANL 185

Query: 179 QDVFNVGGAQAIAALAFGT----ESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPA 234
             ++ +GGAQAIAAL +G       +P  DK+FGPGNA+V EAKR  +   +G ++DMPA
Sbjct: 186 DAIWLIGGAQAIAALTYGAVLDDGEIPACDKLFGPGNAYVAEAKRYAAALPNGPSVDMPA 245

Query: 235 GPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPR 294
           GPSE+LVIAD    P+  A+DLLSQAEH  D+QVIL+   A     +   VE QL  LPR
Sbjct: 246 GPSELLVIADRFCDPEIAAADLLSQAEHDADAQVILVCERAATIDAILAEVEEQLTTLPR 305

Query: 295 AETARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWS 354
           A+ AR +L+ +R I+  D+A+   +SN YGPEHL IQ  +A  LV SI +AG+VF+G W+
Sbjct: 306 ADIARASLSEARAILVSDMAEACAVSNLYGPEHLAIQAEDAEALVASIRAAGAVFVGRWA 365

Query: 355 PESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAE 414
            E+ GDYA+G +HVLPT G   T   +  A F   M+VQ +++ G   L      LA  E
Sbjct: 366 AETLGDYAAGPSHVLPTDGGARTLGGITTASFMTSMSVQTVTEAGAERLGPIAARLARLE 425

Query: 415 RLTAHKNAVTLR 426
            L AH  A  LR
Sbjct: 426 GLEAHARAADLR 437


>UniRef50_A4QA32 Histidinol dehydrogenase n=16 Tax=cellular organisms
           RepID=A4QA32_CORGB
          Length = 408

 Score =  478 bits (1232), Expect = e-133,   Method: Composition-based stats.
 Identities = 138/403 (34%), Positives = 213/403 (52%), Gaps = 10/403 (2%)

Query: 39  ILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETF 98
           ++ +++ARGDEA+REYS KFD     +  V  E++    +R+ +++ + +      +   
Sbjct: 1   MIADIRARGDEAVREYSLKFDNYGPDSFLVQGEQLQEILDRVPEQVIEDIKFVQDQVRKV 60

Query: 99  HTAQKLP--PVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKK 156
             AQ       ++ET PGV   Q   P+ S G Y+PGG  PL ++  M    A +AG K+
Sbjct: 61  AQAQLQSMGEFEIETLPGVHIGQKNVPIDSAGAYVPGGKYPLLASAHMTILTAKVAGVKR 120

Query: 157 VVLCSP---PPIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAF 213
           VV C+P     + D  + A  L G  +++ +GG QAIAA+A GTE++  V  I GPGNAF
Sbjct: 121 VVACTPLIQGEVPDATVAAMHLAGADEIYLLGGIQAIAAMAIGTETIKPVSIIAGPGNAF 180

Query: 214 VTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTP 273
           V EAKRQ+   +    ID+ AGP+E L++AD    P   A DLLSQAEHGPDS  +L++ 
Sbjct: 181 VAEAKRQLFGEV---GIDLLAGPTETLIVADETTDPFIAAVDLLSQAEHGPDSPAVLIST 237

Query: 274 AADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQT 332
              +A +V + +   L E+P  + A  A  +   + V + +     +++++  EH+ I T
Sbjct: 238 DRAVAEQVIDHINELLPEMPTKDYAEVAWRDWGEVHVVESIEDAFSLADKFASEHVQILT 297

Query: 333 RNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTV 392
            + R  +D +   G++FLG+ +  S GD   GTNHVLPT G       L +  + + +T 
Sbjct: 298 ASPRRALDEMKHYGALFLGEGTCVSYGDKVIGTNHVLPTRGAARYTGGLWVGKYVRTITY 357

Query: 393 QELSKEGFSA-LASTIETLAAAERLTAHKNAVTLRVNALKEQA 434
           QE++ E  SA         A  ER   H  +  +R       A
Sbjct: 358 QEVTNEDSSAFFGELCGRAARVERFEGHARSGDVRAAKYAGAA 400


>UniRef50_Q64EP7 Histidinol dehydrogenase n=2 Tax=environmental samples
           RepID=Q64EP7_9ARCH
          Length = 419

 Score =  476 bits (1225), Expect = e-133,   Method: Composition-based stats.
 Identities = 172/438 (39%), Positives = 246/438 (56%), Gaps = 32/438 (7%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
               +        + +    R       ++   VN+I+  VK+RGD AL +Y+ KFD   
Sbjct: 1   MIKKLK----EVYETKDFFDRG--LDLTAVMPLVNEIIAEVKSRGDRALLDYTEKFDGVK 54

Query: 63  V---TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQP-----G 114
                 L+V   EI  A   + D L +++  A + I+ FH  QK      + +      G
Sbjct: 55  FLRQKDLEVRRSEIEDAKRNVDDHLLRSIEKASEAIKKFHYRQKRRVEVEKGEDKGGTEG 114

Query: 115 VRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEI----- 169
           +       P+  VG Y+P   A  FST LM   PA IAG + +++C+PP     +     
Sbjct: 115 MFIDNTYVPLDVVGAYVP---ASYFSTALMCVIPAKIAGVRNILVCTPPGKDGAVDSLTL 171

Query: 170 LYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAA 229
           L AA+L G   +F VGGAQAIAALAFGTE++PKV KI GPGN +VT AK   + R  G  
Sbjct: 172 LAAAELAGATRIFKVGGAQAIAALAFGTETIPKVQKIVGPGNVYVTAAKM--AARAQGVE 229

Query: 230 IDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQL 289
           ID PAGPSE+++IAD  A P F+ +D+L+QAEHG  S+ +LLT +A    R+A  VERQ+
Sbjct: 230 IDFPAGPSEIIIIADETANPLFIVADMLAQAEHGAKSKAVLLTDSA----RIAAEVERQI 285

Query: 290 AELPRAETARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVF 349
               R E   +    + +I+  D+ +C+E++N+Y PEHL I  R  +E++  I +AGSVF
Sbjct: 286 ----RTEAGDEEGEQNGIILGDDIGECIELANEYAPEHLEIMVREPKEVLKRIKNAGSVF 341

Query: 350 LGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIET 409
           +GD+SP +AGDYA+G NHVLPT GY  + S L +  F +RMTVQ L KEG + +   +  
Sbjct: 342 VGDYSPVAAGDYATGANHVLPTAGYAKSFSGLDVHHFMRRMTVQWLDKEGLAKIKDVVVK 401

Query: 410 LAAAERLTAHKNAVTLRV 427
           ++ AE +  H  +V  R 
Sbjct: 402 MSRAEGMEKHAQSVEARF 419


>UniRef50_B4W8G9 Histidinol dehydrogenase n=2 Tax=Caulobacteraceae
           RepID=B4W8G9_9CAUL
          Length = 435

 Score =  476 bits (1225), Expect = e-132,   Method: Composition-based stats.
 Identities = 193/434 (44%), Positives = 261/434 (60%), Gaps = 9/434 (2%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
             +IDW+S  A  +R  L RPA   +  +T  V  ILD+V+ARG  A+ ++  K DK   
Sbjct: 1   MKLIDWSSLDAAGKRAALARPAQRTAGDVTDVVRTILDDVRARGGAAVTDWCLKLDKAPP 60

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPV-DVETQPGVRCQQVTR 122
             + ++ E +A A   L     +A+ +A +N+  FH A K      +ET PGVR +   R
Sbjct: 61  RRIAITPEAVAEARNALPPGDVRALRMAAENVRVFHQATKPEDTPFIETTPGVRSKLAWR 120

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGV 178
           P+AS GLYIPGG+APLFS++LMLA PA +AG  + V  +PP     I   ++ AA    +
Sbjct: 121 PIASAGLYIPGGTAPLFSSLLMLAIPAGVAGVGERVAVTPPDKNGGIHPAMILAAAEAEL 180

Query: 179 QDVFNVGGAQAIAALAFGTE----SVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPA 234
             ++ +GGAQAIAAL FG E     +P  DK+FGPGNA+V EAK+Q S    G A+DMPA
Sbjct: 181 DAIWLMGGAQAIAALTFGVELEDGIIPACDKLFGPGNAYVAEAKKQASALPGGPAVDMPA 240

Query: 235 GPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPR 294
           GPSE++VI D  A P+  A+DLLSQAEH  D+QVIL++ +      +   VE Q+A LPR
Sbjct: 241 GPSELMVIVDRDAAPEIAAADLLSQAEHDADAQVILVSTSRATIDYILSEVEVQVAALPR 300

Query: 295 AETARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWS 354
              AR +LN +R I+ +DL    E++N YGPEHL IQ  +   LVDSI +AG+VF+G ++
Sbjct: 301 EAIARASLNEARAILVRDLDAAAEVANLYGPEHLAIQIDDPEPLVDSIKAAGAVFVGRFA 360

Query: 355 PESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAE 414
            E+ GDYA+G +HVLPT G   T   +  A F   M+VQ +S+ G  ALA     LA  E
Sbjct: 361 AETLGDYAAGPSHVLPTDGGARTLGGVTTASFMTTMSVQLVSEAGARALAPIAARLARME 420

Query: 415 RLTAHKNAVTLRVN 428
            L AH  A  LR  
Sbjct: 421 GLEAHARAADLRAE 434


>UniRef50_A9A5X6 Histidinol dehydrogenase n=2 Tax=Thaumarchaeota RepID=A9A5X6_NITMS
          Length = 420

 Score =  475 bits (1224), Expect = e-132,   Method: Composition-based stats.
 Identities = 152/430 (35%), Positives = 237/430 (55%), Gaps = 15/430 (3%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
             II  N+       Q L +     S    + V  IL +VK  GD A+++Y  KF    V
Sbjct: 1   MKIISINNTE-----QFLKKIGTKDSSKNQKIVKSILKDVKKNGDVAVKKYEKKFS-AKV 54

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQ-PGVRCQQVTR 122
           ++L+VS  +IA+A  ++S E   A+ +A   +    +A +    D+  +  G +  +   
Sbjct: 55  SSLRVSQRDIASAYFKVSKEDISAIKLAKSRLSKAESAVRRQFKDITIKSNGTKLSKSFV 114

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGV 178
           P+ SVG Y+PGG+A   S+ +M   PA IAG K++V+ SPP     I    + AA LCG 
Sbjct: 115 PIDSVGCYVPGGAARYPSSAIMSVVPAKIAGVKRIVVVSPPNSSGNIDPLTIVAADLCGA 174

Query: 179 QDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSE 238
            +++  GG Q+IAAL +GT S+ KV+KI GPG AFVT AK  VS  +   +IDM AGP+E
Sbjct: 175 TEIYKTGGVQSIAALTYGTRSIKKVNKIVGPGGAFVTLAKYLVSNIV---SIDMMAGPTE 231

Query: 239 VLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETA 298
           + ++ DS A  D  A DL+SQAEH  D+    LT +  +A+++  +V  +L ++ R +  
Sbjct: 232 LGIVIDSAADVDVAALDLISQAEHSSDTFCYALTTSNSIAKKIQSSVNSKLKDIQRVKIV 291

Query: 299 RQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESA 358
           + +L ++  I     +  ++I+N   PEHL I ++N ++  + I + G +  G  SP SA
Sbjct: 292 KSSLESNGFIGVCKPSDIIDIANDLAPEHLEIISKNPKKW-NKIKNPGLILYGKNSPSSA 350

Query: 359 GDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTA 418
            DY  G+NH+LPT G+  T  SL + DF K +T  E +K+    ++ +++ L  AE L  
Sbjct: 351 SDYLLGSNHILPTNGFGKTRGSLSVLDFVKLLTKIETTKKDLQKISKSMKNLTLAEGLPN 410

Query: 419 HKNAVTLRVN 428
           H  AV  R+ 
Sbjct: 411 HYEAVRGRLK 420


>UniRef50_A3Q131 Histidinol dehydrogenase n=6 Tax=Mycobacterium RepID=A3Q131_MYCSJ
          Length = 474

 Score =  475 bits (1224), Expect = e-132,   Method: Composition-based stats.
 Identities = 157/473 (33%), Positives = 228/473 (48%), Gaps = 48/473 (10%)

Query: 1   MSFNTI-IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFD 59
           ++   I +   + +  Q R  L R  +     +   V  I++ V  RG EA  EY   FD
Sbjct: 6   VTMARIDLRGRTLSTAQLRSALPRGGVDVDAVV-PKVRPIVEAVAERGAEAALEYGEAFD 64

Query: 60  KTTVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQ 119
                +++V AE +A+A   L  +++ A+ VA+      H  Q+         PG    +
Sbjct: 65  GVRPASVRVPAERLASALAELDPDVRAALQVAIDRARAVHADQRRTDTTTTLAPGATVTE 124

Query: 120 VTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP------IADEILYAA 173
              P+  VGLY+PGG+A   S+V+M   PA  AG   +V+ SPP           IL AA
Sbjct: 125 RWVPLERVGLYVPGGNAVYPSSVVMNVVPAQTAGVDSLVIASPPQADHGGLPHPTILAAA 184

Query: 174 QLCGVQDVFNVGGAQAIAALAFGTESV--------------------------------- 200
            L GV +V+ VGGAQA+A LA+G   +                                 
Sbjct: 185 ALLGVDEVWAVGGAQAVALLAYGGTDIDGTGASGAPGDGTGASGAPGDGTGASGAPGDVT 244

Query: 201 --PKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLS 258
               VD I GPGN +VT AKR    ++    ID  AGP+E+ V+AD  A P  VA+DL+S
Sbjct: 245 ELAPVDMITGPGNIYVTAAKRICRSQV---GIDAEAGPTEIAVLADHTADPVHVAADLIS 301

Query: 259 QAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL--NASRLIVTKDLAQC 316
           QAEH   +  +L+T + D+A  +   + RQL      E    AL    S +++  DL   
Sbjct: 302 QAEHDEMAASVLVTTSPDLADAIDRELRRQLETTVHRERVSTALTGEQSAIVLVDDLDAG 361

Query: 317 VEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTA 376
           V + N Y  EHL IQT +A E+   I SAG++F+G ++P S GDY +G+NHVLPT G   
Sbjct: 362 VRVVNAYAAEHLEIQTVDAAEVAGRIRSAGAIFVGPYAPVSLGDYCAGSNHVLPTAGCAR 421

Query: 377 TCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNA 429
             S L +  F + + V + ++     ++  + TLA AE L AH  AV  R  +
Sbjct: 422 HSSGLSVQTFLRGIHVVDYTEAALKDVSGYVITLAQAENLPAHGEAVRRRFES 474


>UniRef50_B2UMH6 Histidinol dehydrogenase n=3 Tax=Verrucomicrobia RepID=B2UMH6_AKKM8
          Length = 432

 Score =  475 bits (1224), Expect = e-132,   Method: Composition-based stats.
 Identities = 158/436 (36%), Positives = 246/436 (56%), Gaps = 11/436 (2%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
             I   +    ++ ++ + R A+   +S+  TVN I+ +V  RGDEAL +Y+A+FDK  +
Sbjct: 1   MKIYRPSDTCFDEMKRRMNRRAL-PEDSVRDTVNAIIRDVSVRGDEALFDYAARFDKAHL 59

Query: 64  --TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVT 121
             ++L V+  E+A A   + + +K+A+AV++ NI  F    +          GV   +  
Sbjct: 60  DSSSLFVTEAELAEAEAMVEESVKEAIAVSLANIHYFSDRSRRRDWSGVNAQGVEVAERF 119

Query: 122 RPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSP----PPIADEILYAAQLCG 177
            P   VG+YIPGG APL ST +M    A  AG +++V  +P      +   +LYA +  G
Sbjct: 120 LPYDRVGIYIPGGKAPLVSTSIMTGGFAQAAGVREIVAATPCGPDGRVNPALLYALKASG 179

Query: 178 VQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPS 237
             ++  +GGAQAIAALA GTESV  V+KIFGPGN FV EAKRQ+   +   AID+  GPS
Sbjct: 180 ATEIVKIGGAQAIAALALGTESVRPVEKIFGPGNRFVVEAKRQL---VGAVAIDLLPGPS 236

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAET 297
           EV+V+AD  A  +F+A+DLL+Q EHGPDS V+ +T +  +  +V   VERQ A L R   
Sbjct: 237 EVMVLADDTADAEFLAADLLAQGEHGPDSVVVFVTTSKALLEQVEAEVERQAALLSRGSI 296

Query: 298 ARQALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPE 356
            R+ L+  +   +   + + VE+ N + PEHL++ TR+   +++ I +AG+++ G  S  
Sbjct: 297 IREVLDKHAYGFLVSSIQEGVELVNAFAPEHLVLVTRDEEAVLNGIRTAGAIYAGSLSTV 356

Query: 357 SAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERL 416
           + GD+ +G +H LPT G   + S L    FQ+R +V  + +      A  +   A  E L
Sbjct: 357 ACGDFLAGPSHTLPTGGAGKSFSGLRADQFQRRTSVVRMDRNAVLNSAPYVAEFARVEGL 416

Query: 417 TAHKNAVTLRVNALKE 432
            AH +++ +R   +  
Sbjct: 417 DAHNHSIQVRAARVDR 432


>UniRef50_Q1AX10 Histidinol dehydrogenase n=1 Tax=Rubrobacter xylanophilus DSM 9941
           RepID=Q1AX10_RUBXD
          Length = 418

 Score =  475 bits (1223), Expect = e-132,   Method: Composition-based stats.
 Identities = 160/434 (36%), Positives = 231/434 (53%), Gaps = 20/434 (4%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
               +D     A +  + L RP    S  +   V  +++ V+ RGDEAL EY  +FD   
Sbjct: 1   MAARLDARGLDAREVVRRLRRPRGFLSREVRAAVRQVVEEVRERGDEALLEYGERFDGVR 60

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
              L+V  EEI  A   L  EL +A   A++N+  FH  +     ++E + G R  Q  R
Sbjct: 61  PDPLRVPREEIERARAALPGELAEAFRTAIENVRRFHERELDRSWELE-RGGARLGQRVR 119

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPI----ADEILYAAQLCGV 178
           P+   G+Y+PGG     ST++M A PA +AG +++ +C+PP         +L  A L G+
Sbjct: 120 PLRRAGIYVPGGHGAYPSTLVMTAVPAQVAGVEELCVCTPPGPDGRANPRLLAVAGLLGI 179

Query: 179 QDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSE 238
            +V+  GGAQA+AA+AFGTESVP+VDKI GPGN +VT AK +V   +    +D P GPSE
Sbjct: 180 GEVYAAGGAQAVAAMAFGTESVPRVDKIVGPGNDYVTAAKLEVFGEV---GVDAPQGPSE 236

Query: 239 VLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETA 298
           ++V+AD  A P+ VA DL++QAEH   +  +LLTP+  +A  V    E  L+  P     
Sbjct: 237 LVVVADGSARPERVALDLMAQAEHLSGATSVLLTPSGALASGV----EPLLSGRPSEHIT 292

Query: 299 RQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESA 358
                   L++ +DL Q +EISN Y PEH+ +    A   ++ + +AG V +GD SP + 
Sbjct: 293 --------LVLVRDLEQALEISNLYAPEHVHLNCEGAGAALERVEAAGLVAVGDLSPVAL 344

Query: 359 GDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTA 418
            DYA+G +H LPT G     S+LG  DF  R+     S+E    L   +E LA  E    
Sbjct: 345 SDYAAGPSHALPTGGTARWASALGTHDFLTRINHMRFSREALRELGPHVERLARMEGFEN 404

Query: 419 HKNAVTLRVNALKE 432
           H  +V  R    + 
Sbjct: 405 HAASVAARREKEEG 418


>UniRef50_D2RSH8 Histidinol dehydrogenase n=1 Tax=Haloterrigena turkmenica DSM 5511
           RepID=D2RSH8_9EURY
          Length = 432

 Score =  474 bits (1220), Expect = e-132,   Method: Composition-based stats.
 Identities = 161/430 (37%), Positives = 239/430 (55%), Gaps = 10/430 (2%)

Query: 9   WNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKV 68
                   +     R   +  ++I+  V +I+D V   GD A+RE++++FD   +  + +
Sbjct: 8   LADLGPADRTAFFDR--DAGIDAISDDVREIVDRVHEEGDVAVREFTSEFDDVELGNIDI 65

Query: 69  SAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVG 128
           +      A E L  ++++A+  A  N+  FH AQ       E  PG    +  RP+  VG
Sbjct: 66  TDA-CERAYEDLEGDVREAIETAADNVREFHEAQLPEDWRREFGPGRELGRRFRPIERVG 124

Query: 129 LYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP--PIADEILYAAQLCGVQDVFNVGG 186
           +Y+PGGSA   S+ +M   PA +AG   V + +PP   +    L A  + G   V++VGG
Sbjct: 125 VYVPGGSAAYPSSAIMGVVPAVVAGVDHVAVVTPPADELNPVTLAAIHVAGADAVYSVGG 184

Query: 187 AQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSG 246
           AQAIA LA+GTE++ +V KI GPGN +VT AK  V   ++   ID  AGPSEV+V+AD  
Sbjct: 185 AQAIAGLAYGTETITRVQKIVGPGNKWVTAAKAAVRGDVE---IDFLAGPSEVVVVADET 241

Query: 247 ATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNA-- 304
           A PD VA++L++QAEH P++ V+ +T  A+ A  VA AV+ Q     R +  R A     
Sbjct: 242 ADPDLVAAELVAQAEHDPNASVVAVTDDAETADAVAAAVDGQTEARKREDVIRGAFENDA 301

Query: 305 SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASG 364
           S +++ + +++ +  + +Y PEHL I   +   +++ I SAGSVFLG  +P +AGDYASG
Sbjct: 302 SGVLLARSMSEAILFTEEYAPEHLSIIADDEESILERIDSAGSVFLGPNTPVAAGDYASG 361

Query: 365 TNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVT 424
           TNHVLPT G       L +  F +  TVQ LS EG + +  TI TLA AE L AH  +V 
Sbjct: 362 TNHVLPTNGGARVTGGLSIETFLRSTTVQRLSAEGLADIGDTITTLADAEGLEAHAESVR 421

Query: 425 LRVNALKEQA 434
            R+   +   
Sbjct: 422 QRLEDREGDG 431


>UniRef50_B0S9F2 Histidinol dehydrogenase n=6 Tax=Leptospira RepID=HISX_LEPBA
          Length = 430

 Score =  473 bits (1217), Expect = e-132,   Method: Composition-based stats.
 Identities = 164/427 (38%), Positives = 235/427 (55%), Gaps = 11/427 (2%)

Query: 11  SCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSA 70
              +++     ++ A     + T  +  IL++V+ +GD+AL  Y+  FD   ++ L +  
Sbjct: 9   DRNSKELYSRFLQGAREDLTTATDRILPILESVRTQGDQALFSYTEMFDGIKLSQLTIDP 68

Query: 71  EEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLY 130
           ++I      + ++ K+A   A  NIE FH  QK      +   G R      P+ S+ +Y
Sbjct: 69  KKIKT---NVDEKTKEAFLRAKSNIEAFHMEQKRESWS-KVIDGNRLGVKYTPIPSLAVY 124

Query: 131 IPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIA--DEILY-AAQLCGVQDVFNVGGA 187
            PGG A   S+VLM   PA IAG   + L +PP      EIL   AQ+  +  +  VGGA
Sbjct: 125 APGGKALYPSSVLMGIIPAKIAGVPSIQLITPPQKDGIPEILVWLAQIMDIDRIVTVGGA 184

Query: 188 QAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGA 247
           Q IAA A+GTESVPK + I GPGNA+V  AK  +S +     I+ PAGPSEV +IAD  A
Sbjct: 185 QGIAAAAYGTESVPKSEFIVGPGNAYVAAAKSYLSGQ-GLIGIESPAGPSEVCIIADENA 243

Query: 248 TPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQA--LNAS 305
            P ++A D+LSQAEHG DS  ILLT    +A+RV+E +E   +E P+    +Q      S
Sbjct: 244 NPKWIACDMLSQAEHGEDSSAILLTTDLTLAKRVSEELEIAFSERPKRLQMKQTAIYENS 303

Query: 306 RLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGT 365
            ++V   L  C+  SN+  PEHL IQT++   +   I  AGSVFLG +SP + GDY SGT
Sbjct: 304 SILVFPTLDDCIWFSNELAPEHLEIQTKDYESVFAKIEHAGSVFLGPYSPVAMGDYISGT 363

Query: 366 NHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERL-TAHKNAVT 424
           NH+LPT   +   SSLG+  F KR+T QE++KE    L   ++ ++  E L   H  +V 
Sbjct: 364 NHILPTARGSRIYSSLGVDTFLKRVTFQEVTKESLENLYPFVKLMSELEGLDEEHGTSVK 423

Query: 425 LRVNALK 431
           +R    +
Sbjct: 424 VRTRQFQ 430


>UniRef50_D1B7M0 Histidinol dehydrogenase n=2 Tax=Bacteria RepID=D1B7M0_THEAS
          Length = 424

 Score =  472 bits (1215), Expect = e-131,   Method: Composition-based stats.
 Identities = 162/420 (38%), Positives = 236/420 (56%), Gaps = 13/420 (3%)

Query: 19  QLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASE 78
           ++  R + S    ++  V  I+D V   GD A+ E S   D+++  ++ V  EE+  A  
Sbjct: 8   RVKDRASSSDLYGVSHEVRRIIDWVVLHGDRAVLEGSRLHDRSSRDSILVPVEELQRAHR 67

Query: 79  RLSDELKQAMAVAVKNIETFHTAQK---LPPVDVETQPGVRCQQVTRPVASVGLYIPGGS 135
            +  EL +A+  A  N+ETF   QK   +P  + E + GV       PV S G+YIPGGS
Sbjct: 68  SMDPELLEAVRYAASNVETFAQRQKGALMPLEESEVRDGVYLGHRVVPVDSCGIYIPGGS 127

Query: 136 APLFSTVLMLATPASIAGCKKVVLCSP-----PPIADEILYAAQLCGVQDVFNVGGAQAI 190
            PL ST +MLA PA +AG  ++  C+P           +L      GV +V+  GGA A+
Sbjct: 128 YPLISTAVMLAVPARVAGVGRICACTPVRRGTNSPDPSVLGTLYELGVTEVYAAGGAYAV 187

Query: 191 AALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPD 250
           AA+A GTES+P VD I GPGN +VTEAKRQ   ++    ID  AGPSEVL+IA  G  PD
Sbjct: 188 AAMAHGTESIPPVDVIVGPGNKYVTEAKRQCFGKV---GIDFVAGPSEVLIIAQEG-DPD 243

Query: 251 FVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIV 309
           F+A DLL+QAEH PD++ +L+T +  +AR+V + VE  L E+  +  AR +  +   ++ 
Sbjct: 244 FIAWDLLAQAEHDPDAKGVLVTTSPALARQVMDRVETILGEIVTSPVARSSWEDHGEVLA 303

Query: 310 TKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVL 369
            + + + VE SN+  PEHL +  ++    +  + + G++F+G+ S E  GDYASG+NH L
Sbjct: 304 AEGMDEAVEFSNRMAPEHLELMVQDPDRWIPRLRNYGALFIGEHSAEVFGDYASGSNHTL 363

Query: 370 PTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNA 429
           PT G +     L +  F K +T Q +++EG   LA     LA AE L AH+ A   R   
Sbjct: 364 PTAGASRYTGGLWVGTFLKVLTSQRVTREGARELARVSALLAQAEGLMAHRGAALARSRK 423


>UniRef50_C1FAE2 Histidinol dehydrogenase n=1 Tax=Acidobacterium capsulatum ATCC
           51196 RepID=C1FAE2_ACIC5
          Length = 428

 Score =  470 bits (1210), Expect = e-131,   Method: Composition-based stats.
 Identities = 165/433 (38%), Positives = 238/433 (54%), Gaps = 16/433 (3%)

Query: 4   NTIIDWNSCTAEQQRQLLMR---PAISASESITRTVNDILDNVKARGDEALREYSAKFDK 60
             ++      A+  +  L R    + ++ E        I+  V+  GD AL  Y AKFD 
Sbjct: 1   MRVLSTRGRGAQAAQDFLSRLLTGSEASYERALPAAQRIVQGVRRGGDAALLRYRAKFDG 60

Query: 61  -TTVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQ 119
                 L++ AEE+ AA +  + ELK A+  A KNI  F   Q+     ++  PGV   Q
Sbjct: 61  IAASEPLRIPAEEMEAAWKATTAELKAALKQAAKNIRRFAQKQRPRDFTLQMAPGVTAGQ 120

Query: 120 VTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQ 179
              P+ +VG Y+P G  PL ST+LM A PA +AG +++V  SP   A E L AA + GV 
Sbjct: 121 KVIPLEAVGCYVPSGRYPLPSTLLMTAIPAQVAGVRRIVAVSP-RPAKETLAAAHMLGVA 179

Query: 180 DVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEV 239
           + + +GGAQA+AALA+GT S+ +V KI GPGNA+VT AK+ VS       IDM AGP+E+
Sbjct: 180 EFYRIGGAQAVAALAYGTASIERVGKIVGPGNAYVTAAKKAVSFD---CGIDMLAGPTEI 236

Query: 240 LVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETAR 299
            VIA    T + +A+DL++QAEH PD+  IL+T  A + R VA   + +         A+
Sbjct: 237 -VIASENGTVEGIAADLVAQAEHDPDAIAILVTSNAALGRAVAAKTKLRAQS---NAIAK 292

Query: 300 QAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESA 358
           Q++     +I+T+D+ +   ++NQ   EHL   T ++   +  + +AGSVF+G WS +  
Sbjct: 293 QSIAANGAVILTRDVEEARMLTNQLAAEHL---TVDSSADLAWVRNAGSVFVGRWSSQPL 349

Query: 359 GDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTA 418
           GDY SG NH LPT G       L + D+ K +TVQE S  G   L  +   LA AE L  
Sbjct: 350 GDYVSGPNHTLPTSGLARLRGGLSVMDYLKLVTVQEYSATGVRQLGPSAVALAEAEGLVG 409

Query: 419 HKNAVTLRVNALK 431
           H +AV +R+ + K
Sbjct: 410 HADAVRVRLQSAK 422


>UniRef50_Q2HFX2 Putative uncharacterized protein n=1 Tax=Chaetomium globosum
           RepID=Q2HFX2_CHAGB
          Length = 817

 Score =  467 bits (1203), Expect = e-130,   Method: Composition-based stats.
 Identities = 188/421 (44%), Positives = 245/421 (58%), Gaps = 34/421 (8%)

Query: 24  PAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALK--------VSAEEIAA 75
           P  +A E IT  V D+    +   DEALR  S K   T +  +         V       
Sbjct: 419 PKEAAPERITMKVFDMATASRKELDEALRRPSQKSSDTIMKIITPIIDDTSPVLKAPFPE 478

Query: 76  ASERLSDELKQAMAVAVKNIETFHTAQKL-PPVDVETQPGVRCQQVTRPVASVGLYIPGG 134
           +  +L  E  +AM V+ +NI  FH AQK   P+ VET PGV C + +RP  +VGLY+PGG
Sbjct: 479 SLMQLPTETIKAMDVSFENIRKFHAAQKEEKPLQVETIPGVVCSRFSRPPEAVGLYVPGG 538

Query: 135 SAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVFNVGGAQAIAALA 194
           +A L ST  ML  PA +A CKK+VL SPP                       + A+AA+A
Sbjct: 539 TAVLPSTAFMLGVPAMVAACKKIVLASPPR----------------------SDAVAAMA 576

Query: 195 FGTESVPKVDKIFGPGNAFVTEAKRQVSQRLD-GAAIDMPAGPSEVLVIADSGATPDFVA 253
           +GTESV KVDKI GPGN FVT AK  VS   + G  IDMPAGPSEVLVIAD  A P FVA
Sbjct: 577 YGTESVSKVDKILGPGNQFVTAAKMFVSNDTNAGVGIDMPAGPSEVLVIADKDANPAFVA 636

Query: 254 SDLLSQAEHGPDSQVILLTPAADMAR--RVAEAVERQLAELPRAETARQALNASRLIVTK 311
           SDLLSQAEHG DSQVIL+      A+   + + V +Q   LPR +  R ++  S  +  K
Sbjct: 637 SDLLSQAEHGVDSQVILIAIDLTDAQLLAIEDEVHKQAMALPRVDIVRGSIAHSLTVRVK 696

Query: 312 DLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPT 371
            + + +EISNQY PEHLI+Q ++A  +VD + +AGSVF+G+W+PES GDY++G NH LPT
Sbjct: 697 TVDEAMEISNQYAPEHLILQIKDAESVVDKVMNAGSVFIGEWTPESVGDYSAGVNHSLPT 756

Query: 372 YGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNALK 431
           YGY    S + LA F K +T   L+ EG   +   +  LA  E L AH+ AV++R+  + 
Sbjct: 757 YGYAKQYSGVNLASFVKHITSSNLTAEGLRNVGEAVMQLAKVEELEAHRRAVSIRLAHMD 816

Query: 432 E 432
           +
Sbjct: 817 Q 817


>UniRef50_B6A0U7 Histidinol dehydrogenase n=1 Tax=Rhizobium leguminosarum bv.
           trifolii WSM2304 RepID=B6A0U7_RHILW
          Length = 448

 Score =  466 bits (1200), Expect = e-130,   Method: Composition-based stats.
 Identities = 164/441 (37%), Positives = 235/441 (53%), Gaps = 16/441 (3%)

Query: 6   IIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV-- 63
           I   ++    Q++ LL R     S  I   VN I++ V+  GD AL +++ +FDK  V  
Sbjct: 8   IHTLSALDDAQRKALLQRTESDLSAFI-DKVNPIIEAVRIDGDAALADFARQFDKAQVAA 66

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDV-ETQPGVRCQQVTR 122
             L+ + EE +AA   +  EL   +  A  NI  FH  Q    + + ET  GV       
Sbjct: 67  DQLRATTEEFSAARASIDPELITTLEFAAGNIRHFHEKQMPETLVLHETHRGVLVGDRWN 126

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGV 178
            + SV  Y+P G     S+VLM A PA +AG +KVV+ +PP     +    L AA++ GV
Sbjct: 127 AIDSVACYVPRGKGSFPSSVLMTAIPAKVAGVRKVVIITPPGPDGTVDPATLVAAEIAGV 186

Query: 179 QDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSE 238
            DVF  GGAQAIAA+AFGT++VPK DK+ GPG+ +V  AK+Q+S  +D  +   PAGPSE
Sbjct: 187 SDVFKCGGAQAIAAVAFGTQTVPKCDKVVGPGSPWVVAAKKQLSSLIDPGS---PAGPSE 243

Query: 239 VLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELP--RAE 296
           +++ +D     + VA DL  ++EHGPDS V  +T  AD A  VA  V    + +   RA+
Sbjct: 244 LIIFSDGSVPAELVALDLCVESEHGPDSSVFFVTDNADFANAVASCVPALWSRMGNIRAQ 303

Query: 297 TARQALN--ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWS 354
            ++  L+     +++ +  A  +   N Y PEHL +   NA + +     AG + LG  S
Sbjct: 304 YSKTVLSGPRGGIVIARTRADALAFVNDYAPEHLAVLADNAWQYLACFEHAGEILLGPHS 363

Query: 355 PESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAE 414
             S  ++  G +HVLPT G   T S L + DF KR ++  LSKE +   A+  E LA  E
Sbjct: 364 AISVANFVLGPSHVLPTGGAAKTTSPLSVFDFLKRTSIASLSKEAYGGFAAHAERLARYE 423

Query: 415 RLTAHKNAV-TLRVNALKEQA 434
               H NAV T+R  AL+  A
Sbjct: 424 GFDGHANAVSTIRDEALRSAA 444


>UniRef50_D2R570 Histidinol dehydrogenase n=1 Tax=Pirellula staleyi DSM 6068
           RepID=D2R570_9PLAN
          Length = 454

 Score =  466 bits (1199), Expect = e-130,   Method: Composition-based stats.
 Identities = 159/403 (39%), Positives = 227/403 (56%), Gaps = 12/403 (2%)

Query: 33  TRTVNDILDNVKARGDEALREYSAKFDKTTVTA--LKVSAEEIAAASERLSDELKQAMAV 90
           T  V  I  +V+ RG  A+ +YS K D+  +T   ++VS  E+ AA          A+A 
Sbjct: 57  TEVVETICRDVRERGIAAVLDYSKKLDRADLTPETIRVSQAELDAAHAAADPAFLAAIAR 116

Query: 91  AVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPAS 150
             +NI  F TA     V+V  + GV  +Q  +P+  +G+ +PGG+A   STVLM A PA 
Sbjct: 117 IQQNILEFQTAILHKEVEVR-RNGVVLRQRYQPLERIGICVPGGAAAYPSTVLMTAVPAQ 175

Query: 151 IAGCKKVVLCSPPPI----ADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKI 206
            AG  ++V+ +PP        ++L   +  GV +V+ +GGAQ +AALA+G E +PKVDKI
Sbjct: 176 AAGVSQIVVIAPPTDFGANNRDVLATCKAIGVTEVYRMGGAQGVAALAYGVEGIPKVDKI 235

Query: 207 FGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDS 266
            GPGN FV  AKR V   +D   ID  AGPSEV+VI+D     DF A+DLL+QAEH P +
Sbjct: 236 VGPGNLFVALAKRHVYGEVD---IDSIAGPSEVVVISDETTRADFTAADLLAQAEHAPGA 292

Query: 267 QVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQCVEISNQYGP 325
             IL+T +          +ER +  + R+E   Q+L +   LI+     +   ++++  P
Sbjct: 293 -SILITWSRTALEATKRELERLVQTISRSELTLQSLRDFGCLILVDSPEEACRVTSEIAP 351

Query: 326 EHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLAD 385
           EHL I T NA  L+  I +AG+ FLG++SP + GDYA+G +HVLPT G     S L    
Sbjct: 352 EHLHIATENAGALLAKIRNAGATFLGNYSPVALGDYAAGPSHVLPTGGTARWASGLSANH 411

Query: 386 FQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVN 428
           F +  +V + S E    +A  I+ LA  E LTAH+ +V LRV 
Sbjct: 412 FLRSSSVIDYSAEALRDIAPAIQMLADKEGLTAHRLSVDLRVE 454


>UniRef50_Q82AA6 Histidinol dehydrogenase n=29 Tax=Actinobacteridae RepID=HISX_STRAW
          Length = 441

 Score =  466 bits (1199), Expect = e-130,   Method: Composition-based stats.
 Identities = 151/437 (34%), Positives = 231/437 (52%), Gaps = 16/437 (3%)

Query: 3   FNTIIDWNS---CTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFD 59
             + ID            R LL R     S ++ + V  I + V  RGD AL +++ KFD
Sbjct: 1   MISRIDLRGDALPEGSALRDLLPRADFDVSAALEK-VRPICEAVHHRGDAALIDFAEKFD 59

Query: 60  KTTVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQ 119
              + +++V A  +A A E+L   ++ A+  +++     H  Q+      +  PG    +
Sbjct: 60  GVRLESVRVPARALADALEQLDPAVRAALEESIRRARLVHREQRRTTHTTQVVPGGSVTE 119

Query: 120 VTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP------IADEILYAA 173
              PV  VGLY PGG +   S+V+M   PA  AG + + L SP            IL A 
Sbjct: 120 KWVPVDRVGLYAPGGRSVYPSSVVMNVVPAQEAGVESIALASPAQAEFGGLPHPTILAAC 179

Query: 174 QLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMP 233
            L GV +V+  GGA A+A  A+GTES    D + GPGN +V  AKR  + ++    ID  
Sbjct: 180 ALLGVDEVYAAGGATAVAMFAYGTESCAPADMVTGPGNIWVAAAKRYFTGKI---GIDAE 236

Query: 234 AGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELP 293
           AGP+E+ V+ADS A P  VASDL+SQAEH P +  +L+T + ++A  V + +E Q+A   
Sbjct: 237 AGPTEIAVLADSTADPVHVASDLISQAEHDPLAAAVLVTDSVELADAVEKELEPQVAATK 296

Query: 294 R-AETARQALN--ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFL 350
              +    AL    S +++   + + + + + YG EHL IQT +A  + D + +AG++F+
Sbjct: 297 HIDDRIVPALKGRQSAIVLVDGVDEGLRVVDAYGAEHLEIQTADAAAVADRVRNAGAIFI 356

Query: 351 GDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETL 410
           G W+P S GDYA+G+NHVLPT G     S L +  F + + + + +K+  + +A  + TL
Sbjct: 357 GPWAPVSLGDYAAGSNHVLPTGGCACHSSGLSVQSFLRGIHIVDYTKDALADVAHHVVTL 416

Query: 411 AAAERLTAHKNAVTLRV 427
           A AE L AH  A+  R 
Sbjct: 417 AEAEDLPAHGAAIKARF 433


>UniRef50_Q5JFR5 Histidinol dehydrogenase n=9 Tax=cellular organisms
           RepID=HISX_PYRKO
          Length = 376

 Score =  466 bits (1199), Expect = e-129,   Method: Composition-based stats.
 Identities = 151/401 (37%), Positives = 229/401 (57%), Gaps = 29/401 (7%)

Query: 30  ESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELKQAMA 89
           + +   V +IL++++ RG EALREYS +FD  +    +VS  E   A E + +E K+ + 
Sbjct: 2   KGLEEYVREILEDIRRRGLEALREYSERFDNYS-GPFRVSEGEFEEAEELVPEEDKRVIE 60

Query: 90  VAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPA 149
             ++ +  +H  Q    V++  + G     + RP+  +G+Y+PGG  PL ST++M+  PA
Sbjct: 61  ETMERLWEYHARQ-FRDVELYIKRGSLYGLIYRPIGRIGIYVPGGK-PLPSTLMMVGIPA 118

Query: 150 SIAGCKKVVLCSPPP---IADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKI 206
            IAG +++ + +PP    +   +LY A+L G+++V+ +GG  AIAA+A+G   + +VDKI
Sbjct: 119 RIAGVREIAVTTPPKDGKVNPYVLYVAKLLGIEEVYKLGGVGAIAAMAYGV-GMRRVDKI 177

Query: 207 FGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDS 266
           FGPGN FV EAKRQV   +    ID  AGPSE+ VIAD  A  D+V +DLLSQ EHG DS
Sbjct: 178 FGPGNRFVNEAKRQVFGIV---GIDSLAGPSEIAVIADESADKDYVLADLLSQLEHGKDS 234

Query: 267 QVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQCVEISNQYGPE 326
           +  LLT + ++A               R            +++ ++L +C E +N+  PE
Sbjct: 235 KAWLLTTSRELAD-----------YCSREGI--------EVLLCRNLEECAEKANEIAPE 275

Query: 327 HLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADF 386
           HL I T N  ELVD I +AG+++LG ++P  A DY  G NHVLPT G       L + DF
Sbjct: 276 HLEIITENPEELVDLIENAGAIYLGPYTPVPAADYFLGVNHVLPTGGAARFSGVLTVMDF 335

Query: 387 QKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRV 427
            K +T+  +S+E F A       LA  E + AH+ ++ +R 
Sbjct: 336 MKPITLARVSREEFLAYRRLGMRLAEIEGMEAHRRSLEVRR 376


>UniRef50_Q3IQR5 Histidinol dehydrogenase n=10 Tax=Halobacteriaceae RepID=HISX_NATPD
          Length = 422

 Score =  464 bits (1196), Expect = e-129,   Method: Composition-based stats.
 Identities = 169/429 (39%), Positives = 238/429 (55%), Gaps = 11/429 (2%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
             +      + E +  L  R   +  E    +V DI+  V+  GD ALR Y+ +FD   +
Sbjct: 1   MNVSAVADLSPEARAALFER--DAGIEDARESVRDIIGRVREEGDVALRSYAKEFDDVDI 58

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRP 123
             L V+ +E   A + L D+L+ A+  A +NI TFH  Q       E   G    +  RP
Sbjct: 59  GTLAVT-DEAERAYDDLDDDLRDAIETAAENIRTFHERQVPDDWR-EQFDGRELGRRYRP 116

Query: 124 VASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP--PIADEILYAAQLCGVQDV 181
           +  VG+Y PGG+A   S+VLM   PA +AG   V + +PP   +    L AA + G   V
Sbjct: 117 LERVGVYAPGGTAAYPSSVLMGVIPAVVAGVDHVAVATPPAEELPAATLAAAHVAGADAV 176

Query: 182 FNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLV 241
           + VGGAQAIAALA+GTESV  V K+ GPGN +VT AK +V   ++   ID  AGPSE+LV
Sbjct: 177 YQVGGAQAIAALAYGTESVSAVQKVVGPGNRWVTAAKAEVRGDVE---IDFLAGPSELLV 233

Query: 242 IADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQA 301
           + D  A P+ +A+D+++QAEH P++ V+ ++     A  VA+A ERQ     R E    A
Sbjct: 234 VCDDTADPELIAADMVAQAEHDPNASVVCVSDDEATAEAVADACERQATARERTEAIESA 293

Query: 302 LNA--SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAG 359
           L    S ++  + +++ V  + +Y  EHL I   +   L+D I SAGSVFLG +SP + G
Sbjct: 294 LENDASAVLCARSMSEAVLFAEEYAAEHLSIVAADEEALLDRIDSAGSVFLGGFSPVAVG 353

Query: 360 DYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAH 419
           DYASGTNHVLPT G       L +  F +  TVQ+L ++  S+L  T+ TLA AE L AH
Sbjct: 354 DYASGTNHVLPTGGLAKVAGGLSVDHFVRSTTVQKLDEDALSSLRETVTTLARAEGLEAH 413

Query: 420 KNAVTLRVN 428
             +V  R +
Sbjct: 414 AESVDKRFD 422


>UniRef50_Q5YYQ0 Histidinol dehydrogenase n=8 Tax=Actinomycetales RepID=HISX_NOCFA
          Length = 445

 Score =  461 bits (1186), Expect = e-128,   Method: Composition-based stats.
 Identities = 159/437 (36%), Positives = 233/437 (53%), Gaps = 17/437 (3%)

Query: 7   IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTAL 66
           +   + +  + R  L R  +    S+   V  +++ V+ RG  A  E+  KFD      +
Sbjct: 12  LRGRTPSTAELRAALPRGGVDVD-SVLHHVRPVVEAVRERGAAAALEFGEKFDGVVPATV 70

Query: 67  KVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVAS 126
           +V A E+A A + L   ++ A+  ++      H  Q+      E  PG    +   PVA 
Sbjct: 71  RVPAAELARALDELDPAVRAALEESIARARRVHADQRRTDTTTEVVPGGTVTERWVPVAR 130

Query: 127 VGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP------IADEILYAAQLCGVQD 180
           VGLY+PGG+A   S+V+M   PA  AG   +V+ SPP           IL AA L GV++
Sbjct: 131 VGLYVPGGNAVYPSSVVMNVVPAQTAGVGSLVVASPPQANFGGLPHPTILAAAALLGVEE 190

Query: 181 VFNVGGAQAIAALAFG---TESVP--KVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAG 235
           V+ VGGAQA+A L++G   T+  P   VD I GPGN +VT AKR     +    ID  AG
Sbjct: 191 VWAVGGAQAVALLSYGGTDTDGAPLDPVDLITGPGNIYVTAAKRLCRGLV---GIDAEAG 247

Query: 236 PSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRA 295
           P+E+ ++AD+ A P  VA+DL+SQAEH   +  +L+T +  +A  V  A+  QLA +  A
Sbjct: 248 PTEIAILADATADPAHVAADLISQAEHDVLAASVLVTDSVALADAVDAALTAQLAVVKHA 307

Query: 296 ETARQAL--NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDW 353
           E  R AL    S  ++  D+ Q + + + Y  EHL IQT +A  +   + SAG+VF+G +
Sbjct: 308 ERVRTALTGKQSGTVLVDDITQGLRVVDAYAAEHLEIQTADASAVAARVRSAGAVFVGPY 367

Query: 354 SPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAA 413
           +P S GDY +G+NHVLPT G     S L +  F + + V E ++     +A  +  LA A
Sbjct: 368 APVSLGDYCAGSNHVLPTAGCARHSSGLSVQTFLRGIHVVEYTEAALKDVAGHVVALADA 427

Query: 414 ERLTAHKNAVTLRVNAL 430
           E L AH  AVT+R  AL
Sbjct: 428 EDLPAHGQAVTVRFEAL 444


>UniRef50_C0GVA3 Histidinol dehydrogenase n=1 Tax=Desulfonatronospira thiodismutans
           ASO3-1 RepID=C0GVA3_9DELT
          Length = 436

 Score =  461 bits (1186), Expect = e-128,   Method: Composition-based stats.
 Identities = 132/421 (31%), Positives = 205/421 (48%), Gaps = 8/421 (1%)

Query: 16  QQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAA 75
           +  +   +     +  I   V  +LD+++ RG+ A+RE +AK+D  + T   +  E+   
Sbjct: 2   ELVKKAKKSLAYGNSRIREAVTFLLDDIRTRGEPAVREMAAKYDGWS-TDFVLQEEKKER 60

Query: 76  ASERLSDELKQAMAVAVKNIETFHTAQKL--PPVDVETQPGVRCQQVTRPVASVGLYIPG 133
               + +++K  +  A   +  F   Q+      +V   PGVR  Q   PV   G Y+PG
Sbjct: 61  LIAMVPEQVKTDIRFAHDQVFNFARMQRQSIQDFEVRPHPGVRLGQRVLPVDVAGCYVPG 120

Query: 134 GSAPLFSTVLMLATPASIAGCKKVVLCSPP---PIADEILYAAQLCGVQDVFNVGGAQAI 190
           G      + +M    A  AG   VV CSPP    IA  + +A  L G   +  +GG Q +
Sbjct: 121 GRFAHACSAIMSVATAKAAGVPFVVACSPPREESIAPAVAFAMDLAGADVILELGGVQGV 180

Query: 191 AALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPD 250
           AA+A+G  +    D + GPGNA+V EAK  ++       ID+ AGP+E  +IAD  A P 
Sbjct: 181 AAMAYGYFTNRPADILVGPGNAYVAEAKALLAGD-GTCGIDVYAGPTESAIIADRSADPM 239

Query: 251 FVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIV 309
            +A DL+SQAEHGPDS V L T   D+A +V   V R +A++P     + A  +   +I+
Sbjct: 240 TIAIDLVSQAEHGPDSPVWLFTDCRDLAYQVLNLVPRVIADMPDPHVPKTAWADFGEIIL 299

Query: 310 TKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVL 369
             +  +   + + Y PEH+ I   +    ++S+ S GS+FLG+ S  + GD  SGTNH+L
Sbjct: 300 CNNRDEICRVCDTYAPEHVQILAADPDWWLESLRSYGSLFLGEGSSVAHGDKCSGTNHIL 359

Query: 370 PTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNA 429
           PT         L +  F K  T QE+  E     ++    L+  E +  H  +   R+  
Sbjct: 360 PTRKAAQHSGGLSVHKFLKISTYQEIDTEASKRFSAVASRLSRVEGMEGHARSCDWRLTK 419

Query: 430 L 430
            
Sbjct: 420 F 420


>UniRef50_B8E2C3 Histidinol dehydrogenase n=1 Tax=Dictyoglomus turgidum DSM 6724
           RepID=B8E2C3_DICTD
          Length = 417

 Score =  459 bits (1183), Expect = e-128,   Method: Composition-based stats.
 Identities = 127/429 (29%), Positives = 216/429 (50%), Gaps = 24/429 (5%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              +I       +     L+R   S  + + + V+ I++ ++ +GD AL  +S KFD   
Sbjct: 1   MINVIKGLDFNLK-----LLRMEESKVKEVEKEVDFIVEEIRTKGDLALHNFSLKFDNYD 55

Query: 63  VTA--LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQV 120
                 K+S  EI      LS++   A+ V ++ ++ ++  +       +        Q+
Sbjct: 56  SKKYGFKISVPEID-----LSNDFATAIKVMIERVKNYYIHEYKNSWFYKDGE-SILGQL 109

Query: 121 TRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPI--ADEILYAAQLCGV 178
             PV SV LY+PGG A   STV+M   PA IAG K + + +PP       +LY  +L G+
Sbjct: 110 IVPVDSVLLYVPGGKASYPSTVVMGLIPAMIAGVKNLYVTTPPSKREDRNLLYTLRLLGI 169

Query: 179 QDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSE 238
           ++++ +GGA AI+A A+GTES+PKVD I GPGN +V  AK++V   ++   ID   GPSE
Sbjct: 170 KELYVLGGAHAISAFAYGTESIPKVDMIIGPGNLYVALAKKRVFGDVN---IDGIFGPSE 226

Query: 239 VLVIAD---SGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRA 295
           +LV  +          +  D L+Q EH P  +  ++ P  ++  +V   ++ ++    R 
Sbjct: 227 ILVWINYRGKDLNLRKIVCDFLAQLEHSPYDRGWMILP-EELLDKVMGLIKEEVEGSGRG 285

Query: 296 ETARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSP 355
           +  ++A+  S LI+ +D  + + + NQ  PEHL I   +    +  I +AG++F+   S 
Sbjct: 286 DILKEAIKNSFLIIEEDEERAINLINQIAPEHLEIIDFSGERHIPYIKNAGAIFINHSS- 344

Query: 356 ESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAER 415
              GD+ +G +H+LPT G     S L +  F KR++  +LS +    LA     +A  E 
Sbjct: 345 -IFGDFIAGPSHILPTGGSAKFSSGLSVNSFLKRISFVKLSAKEQKILAEYGSIIAREEG 403

Query: 416 LTAHKNAVT 424
              H+ ++ 
Sbjct: 404 FYMHEKSLR 412


>UniRef50_Q1D4L9 Histidinol dehydrogenase n=2 Tax=Cystobacterineae
           RepID=Q1D4L9_MYXXD
          Length = 437

 Score =  458 bits (1180), Expect = e-127,   Method: Composition-based stats.
 Identities = 172/423 (40%), Positives = 243/423 (57%), Gaps = 9/423 (2%)

Query: 9   WNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKV 68
            ++   E  R+LL R A  +   +   V +I+  V+A GD+AL E + +FD+  +TAL+V
Sbjct: 16  LSALAREDVRRLLDR-ATGSDARVALRVREIIARVRAEGDQALFELARQFDRVELTALEV 74

Query: 69  SAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVG 128
             E  AAA   L   ++ A+A A +NI   H  QK   V+VET+PGV   +   P+  VG
Sbjct: 75  PREVCAAALAGLEPSVRDALARAARNIALAHAPQKPQWVEVETEPGVLVGRRPDPLGRVG 134

Query: 129 LYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQDVFNV 184
           +Y PGG A   S+VLM   PA +AG  +V++CSPP         +L AA L G   VF++
Sbjct: 135 VYAPGGRAVYPSSVLMGVVPAKVAGVGEVIVCSPPGPDGLPHPSVLAAASLAGADRVFSL 194

Query: 185 GGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIAD 244
           GGA A+AA+A GTESVP+VD+I GPGNA+V EAK QV   +   AI+ PAGPSE+LV+AD
Sbjct: 195 GGAGAVAAMAHGTESVPRVDRIVGPGNAYVAEAKLQV---VGAVAIEAPAGPSEILVVAD 251

Query: 245 SGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-N 303
             A P  VA ++L+QAEH P++  + L     +A  +A  VERQ     R E    AL +
Sbjct: 252 DTANPAAVAREMLAQAEHDPEAACVTLALGDALADAIAAEVERQAERAKRWEIVTSALGS 311

Query: 304 ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYAS 363
              ++    L +       + PEHL+I T + RE +  + +AG+VFLG+ S  + GDY +
Sbjct: 312 RGAVLTVASLEEAWPFVADFAPEHLLIATASPREDLGQVRNAGTVFLGERSSVAYGDYMT 371

Query: 364 GTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAV 423
           G+NHVLPT G     S L L DF +  T Q ++    ++LA  +  LA +E L AH +A 
Sbjct: 372 GSNHVLPTAGLARAYSGLNLLDFYRWTTYQRVAPTAAASLAEDVGRLADSEGLFAHADAA 431

Query: 424 TLR 426
              
Sbjct: 432 RAW 434


>UniRef50_B5YE85 Histidinol dehydrogenase n=1 Tax=Dictyoglomus thermophilum H-6-12
           RepID=B5YE85_DICT6
          Length = 416

 Score =  458 bits (1178), Expect = e-127,   Method: Composition-based stats.
 Identities = 127/428 (29%), Positives = 216/428 (50%), Gaps = 23/428 (5%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              +I              +R   S  + I + V  I++ VK +GD AL ++S ++D   
Sbjct: 1   MINVIRGKDFDPN-----FLRIEDSKIKEIEKNVEFIIEEVKTKGDLALYDFSLRYDNYD 55

Query: 63  VTA--LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQV 120
                 K++  +I      LS +   A+ V ++ ++ ++  +       +    +   Q+
Sbjct: 56  SRKYGFKINVPDID-----LSTDFAVAIKVMIERVKNYYMHEYKNSWFYKDGESIF-GQL 109

Query: 121 TRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPI--ADEILYAAQLCGV 178
             PV SV LY+PGG A   STV+M   PA IAG K + + +PP       +LY  ++ G+
Sbjct: 110 VVPVDSVLLYVPGGRASYPSTVVMGLVPAIIAGVKNLYVTTPPSKRDDKNLLYTLRILGI 169

Query: 179 QDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSE 238
           ++++ +GGA AI+A A+GTES+PKVD I GPGN +V  AK++V   ++   ID   GPSE
Sbjct: 170 KELYLLGGAHAISAFAYGTESIPKVDMIIGPGNLYVALAKKKVFGDVN---IDGIFGPSE 226

Query: 239 VLVIA--DSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAE 296
           VLV    D       V  D L+Q EH P  +  ++  + ++   + E +++++ +  R +
Sbjct: 227 VLVWVNYDKDLNLRKVVCDFLAQLEHSPYDRGWIIV-SENLVYDLLELIKKEVEDSERGD 285

Query: 297 TARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPE 356
             +++L  S LI+ ++    + + NQ GPEHL I        +  I +AG++F+   S  
Sbjct: 286 ILKESLKNSFLIIEENEKNAINLINQIGPEHLEIIDPFGERYIPYIKNAGAIFINHSS-- 343

Query: 357 SAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERL 416
             GD+ +G +H+LPT G     S L +  F KR++  +LS +    LA    T+A  E  
Sbjct: 344 IFGDFIAGPSHILPTGGSAKFSSGLSVNSFLKRISFVKLSTQDQKILAKYGSTIAREEGF 403

Query: 417 TAHKNAVT 424
             H+ ++ 
Sbjct: 404 YMHEKSLR 411


>UniRef50_Q1IKB6 Histidinol dehydrogenase n=1 Tax=Candidatus Koribacter versatilis
           Ellin345 RepID=Q1IKB6_ACIBL
          Length = 415

 Score =  454 bits (1168), Expect = e-126,   Method: Composition-based stats.
 Identities = 176/427 (41%), Positives = 249/427 (58%), Gaps = 16/427 (3%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKT-T 62
             I+     +       L    ++ +  +   V  I+ +V+  GD ALR Y++K D    
Sbjct: 1   MRILRLEKSSG--LLAKLAARGMADASRVEPVVRKIVVDVRKNGDAALRRYASKLDGLGK 58

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
             AL+VS EE+ +A +    E KQA+  A KNIE F   Q       +   G+   Q+ R
Sbjct: 59  TAALRVSTEELKSAWDATRSEFKQAIRAAAKNIERFARWQMPKSWTRDAGDGIELGQIIR 118

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVF 182
           P+ SVG Y+PGG  PL STVLM   PA +AG ++VV+ SP   A E L AA L GV + +
Sbjct: 119 PIESVGCYVPGGRYPLPSTVLMTVVPARVAGVERVVVVSP-NPARETLAAAYLLGVGEFY 177

Query: 183 NVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVI 242
            +GGAQA+AALA+GTESV +V KI GPGN FVT AK+ V+      AIDM AGP+E  ++
Sbjct: 178 RIGGAQAVAALAYGTESVERVAKIVGPGNIFVTTAKKLVAFD---CAIDMLAGPTEAAIV 234

Query: 243 ADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL 302
           +       F+A+DL++QAEH P++ V   T +  +A  V + V    A   +   AR+AL
Sbjct: 235 S-ERGNARFIAADLVAQAEHDPETMVAFFTTSPSLADAVKKQVALLAA---KNTIARKAL 290

Query: 303 N-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDY 361
                + V +D+AQ +E +NQ+  EHL +      +L+++++SAGSVF+GD+S +S GDY
Sbjct: 291 ATRGYIFVAQDIAQAMEAANQFASEHLTVD----EDLLETVSSAGSVFVGDYSAQSFGDY 346

Query: 362 ASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKN 421
           ASG NHVLPT G       L + D+ K +TVQ++S++G  ALA   ETLAAAE L AH  
Sbjct: 347 ASGPNHVLPTGGLARVRGGLSVLDYVKIITVQKISRKGLRALAPIAETLAAAEGLVAHGQ 406

Query: 422 AVTLRVN 428
           +V +R  
Sbjct: 407 SVAIRRA 413


>UniRef50_O33775 Histidinol dehydrogenase n=12 Tax=Sulfolobaceae RepID=HISX_SULSO
          Length = 398

 Score =  454 bits (1168), Expect = e-126,   Method: Composition-based stats.
 Identities = 139/412 (33%), Positives = 219/412 (53%), Gaps = 23/412 (5%)

Query: 21  LMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERL 80
           L     +    +   V DI+++VK +GD AL E + K DK  +  +K   EE+   + +L
Sbjct: 6   LPNERPNDFSRVIPVVKDIIESVKTKGDNALYELTEKLDKVKIDNIKAREEELKTQASKL 65

Query: 81  SDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFS 140
             ++KQA+  A + ++ FH     P +      G+    + R +  +G+Y+P G     S
Sbjct: 66  DPKVKQAIDTAYEQLKAFHEMLVPPNI-GGGYQGISFGVIWRSIEKIGIYVPSGKYSYPS 124

Query: 141 TVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQDVFNVGGAQAIAALAFG 196
           T+LM   PA +A  K++ + SPP     +   + Y A   GV +V+ +GGAQAIAALAFG
Sbjct: 125 TLLMAGIPAKVAKVKEIYVASPPTQEGTVNPALAYVAIKLGVNEVYKIGGAQAIAALAFG 184

Query: 197 TESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDL 256
           TESV KV KI GPGN +V  AK  VS  +    ID   GP+E+++IAD  A  ++VA D+
Sbjct: 185 TESVKKVYKIVGPGNVYVQAAKYLVSSVV---GIDGIEGPTELVIIADETAKAEYVALDM 241

Query: 257 LSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQC 316
            +QAEHGPD+ ++LL+   ++ RRV E +             +       +I TK+L + 
Sbjct: 242 KAQAEHGPDTYIVLLSNDDELIRRVEEKI-------------KNDKKIYYIIKTKNLDEA 288

Query: 317 VEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTA 376
           +EI+N+  PEHL +  ++A  L+D I +AG++ LG+ +P +  DY +G NH+LPT G+  
Sbjct: 289 IEIANKIAPEHLSLYVKDAYTLMDKIVNAGAISLGN-TPPAIIDYVAGPNHILPTNGWAK 347

Query: 377 TCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVN 428
               + + DF K      + ++    L     +LA  E    H  ++  R  
Sbjct: 348 IRGGITVYDFIKPTMYANV-RDINKQLLEASISLANYEGFIIHGKSIGARYE 398


>UniRef50_Q46N53 Histidinol dehydrogenase 2 n=50 Tax=root RepID=HISX2_RALEJ
          Length = 436

 Score =  450 bits (1158), Expect = e-125,   Method: Composition-based stats.
 Identities = 136/422 (32%), Positives = 214/422 (50%), Gaps = 13/422 (3%)

Query: 18  RQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAAS 77
            +   +   + + +  + V ++L  ++ARG +A+R+Y+ + D  +   + ++ ++I   +
Sbjct: 5   LKKAEKTPQTETATAQKVVTEMLAEIQARGKDAVRQYAKQLDGWS-GDIVLTPDQIREQT 63

Query: 78  ERLSDELKQAMAVAVKNIETFHTAQKL--PPVDVETQPGVRCQQVTRPVASVGLYIPGGS 135
           + +   ++  +  A++ +  F  AQ+       VE  PGV   Q   PV  VG Y P G 
Sbjct: 64  KDVPAGVRADIDFAIRQVTDFALAQRESLKEFSVELHPGVTAGQRVLPVNVVGCYAPAGR 123

Query: 136 APLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQDVFNVGGAQAIA 191
               ++  M    A  AG K VV CS P     I   +LYA Q  G   +  +GG QAIA
Sbjct: 124 YAHIASAYMGVATAKAAGVKTVVACSSPFRGQGIHPHVLYAFQAAGADVIMALGGVQAIA 183

Query: 192 ALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDF 251
           ++A+G  +    D + GPGN FV EAKR +  ++    ID+ AGPSEV VIAD  A P  
Sbjct: 184 SMAYGLFTGKPADVVVGPGNKFVAEAKRSLYGQV---GIDVFAGPSEVAVIADETADPAI 240

Query: 252 VASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPR--AETARQAL-NASRLI 308
           VASDL+ QAEHG +S   L T + D+A RV   V   +A+LP    + A  A  +   +I
Sbjct: 241 VASDLVGQAEHGHESPAWLFTTSRDLADRVMALVPELIAKLPPTARDAATAAWRDYGEVI 300

Query: 309 VTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHV 368
           +     + VEIS++Y  EHL + T +    + ++T  GS+FLG+ +  + GD  SG NHV
Sbjct: 301 LCGTREEVVEISDRYASEHLEVHTADLDWWLANLTCYGSLFLGEETTVAFGDKTSGPNHV 360

Query: 369 LPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVN 428
           LPT G       L +  F K +T Q++++E    +      ++  E + AH      R+ 
Sbjct: 361 LPTKGAARYSGGLSVHKFMKTLTWQQMTREATRQIGQVTARISRLEGMEAHARTADDRMA 420

Query: 429 AL 430
             
Sbjct: 421 KY 422


>UniRef50_A9G5W4 HisD protein n=1 Tax=Sorangium cellulosum 'So ce 56'
           RepID=A9G5W4_SORC5
          Length = 460

 Score =  446 bits (1147), Expect = e-123,   Method: Composition-based stats.
 Identities = 163/451 (36%), Positives = 225/451 (49%), Gaps = 28/451 (6%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              I    S   E     L         ++T  V +I+DNV+  G  A+  Y  KF++ T
Sbjct: 1   MLPIYIEGSPQFESTLSALRTRGTGDLANVTPAVTEIIDNVRRGGTSAVLGYIEKFERRT 60

Query: 63  VTAL-KVSAEEIA------AASERLSDELKQAMAVAVKNIETFHTAQKL----------- 104
             AL + +  E         A  RLS E++ A+  A   I  +H  Q+            
Sbjct: 61  SKALVRHAGPEAEGGFGGAEALARLSPEVRAALETAAARIARYHERQRDAGDLGPANVTA 120

Query: 105 -----PPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVL 159
                       + GV      RP+  VG+Y PGG A   S+VLM A PA IAG +++VL
Sbjct: 121 NGPALQAGFSYEEEGVLLGMRVRPLRRVGVYAPGGKARYPSSVLMSAIPARIAGVREIVL 180

Query: 160 CSPPPIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKR 219
            SP    D  L AA L GV  + + GGAQAIAA+A+G   +  VDKI GPGNA+V  AK+
Sbjct: 181 ASP-SADDATLAAAHLSGVTTLLDSGGAQAIAAMAYGLPELAPVDKIVGPGNAYVACAKK 239

Query: 220 QVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMAR 279
            V   +   +ID   GPSE+L +AD  A P  VA+DLLSQAEH   S  +L T +A +A 
Sbjct: 240 LVFGDV---SIDGITGPSEILALADESADPRLVAADLLSQAEHDEASYALLATTSAKLAE 296

Query: 280 RVAEAVERQLAELPRAETARQALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNAREL 338
            VA  ++  L EL R    + +L+  +  +V    A+  EI++Q   EH+     +A  L
Sbjct: 297 AVARELDAALPELTRRAIVQASLSTHAAALVVGSRARLAEIADQLAVEHVAFHVADAEGL 356

Query: 339 VDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKE 398
              I + G+  LGD +P +AGDY +G +HVLPT G     + LG+ DF  R ++   S  
Sbjct: 357 FSEIGTLGAALLGDLTPVAAGDYLAGPSHVLPTGGSARFGAPLGVYDFVTRASLIRYSSA 416

Query: 399 GFSALASTIETLAAAERLTAHKNAVTLRVNA 429
              A    IE LA AE L AH  AV+LR+ +
Sbjct: 417 ALRAQGPIIEKLALAEGLQAHARAVSLRLAS 447


>UniRef50_C7LZ86 Histidinol dehydrogenase n=1 Tax=Acidimicrobium ferrooxidans DSM
           10331 RepID=C7LZ86_ACIFD
          Length = 432

 Score =  444 bits (1142), Expect = e-123,   Method: Composition-based stats.
 Identities = 156/434 (35%), Positives = 223/434 (51%), Gaps = 9/434 (2%)

Query: 1   MSFNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDK 60
           M+  T++D    T   +R  L        E     V +I+ +V+  GD AL + + +FD 
Sbjct: 1   MASLTLVDLRETTGALRRDDLP-GVALPVEGPRALVREIVQSVRTGGDGALADLTERFDG 59

Query: 61  TTVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQV 120
               AL +  E +AAA ERL   L +A+ VA   +   + A++     +    G+  ++ 
Sbjct: 60  VRPRALVLGREAMAAAYERLDRRLAEALRVARDRVREAYEAERPAASSL-VADGIEVRRR 118

Query: 121 TRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLC 176
             PV   G Y+PGG A   S+V+  AT A +AG + VV+ +PP     + D  L A  L 
Sbjct: 119 IVPVERAGCYVPGGQARYPSSVVHTATVARVAGVRDVVVATPPLPDGGLDDATLAACHLA 178

Query: 177 GVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGP 236
           GV  V   GGAQA+AALA+GTES+ +VD I GPGN FV+ AK++V+  +        AGP
Sbjct: 179 GVDTVLLAGGAQAVAALAYGTESLERVDVIVGPGNLFVSLAKQEVAADVGVPG--AFAGP 236

Query: 237 SEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAE 296
           SEV+V+AD    P   A D+  QAEHGP     L+T  A  A +V E +   +   PR  
Sbjct: 237 SEVVVVADGSLEPRVAAIDVAVQAEHGPHGLAWLVTWDARWAEQVLEELAAYVEASPRRA 296

Query: 297 TARQALN-ASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSP 355
                L     L + +D  Q   +++   PEHL +    A    D +  AG VF+G  + 
Sbjct: 297 QLESTLEAHGYLALVRDRDQARLVADAIAPEHLELLYDQAVRDADRVRHAGVVFVGRAAS 356

Query: 356 ESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAER 415
            + GDY +G +HVLPT G     S LGL DFQ+R+ V E+  E  S L   +E LA AE 
Sbjct: 357 AAFGDYVAGPSHVLPTAGTARFASVLGLEDFQRRLHVVEVHDEALSRLGWAVEALADAEG 416

Query: 416 LTAHKNAVTLRVNA 429
           L AH +++ +R  A
Sbjct: 417 LVAHADSIRIRREA 430


>UniRef50_Q0AP81 Histidinol dehydrogenase, Histidinol-phosphatase n=10 Tax=Bacteria
           RepID=Q0AP81_MARMM
          Length = 631

 Score =  438 bits (1127), Expect = e-121,   Method: Composition-based stats.
 Identities = 188/434 (43%), Positives = 259/434 (59%), Gaps = 6/434 (1%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              I++W   + E + + L RPA S+S        DI+D ++ +GDEA+R Y+ + D   
Sbjct: 1   MLDILNWTDASPEARTRALTRPASSSSAGPAA--RDIVDAIRDQGDEAVRAYAKRLDGYA 58

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
               +V    + AA   L     +A+  A   +  FH  Q      VET PGV   +   
Sbjct: 59  PGDFRVPEGVLKAARAALDPRDAEAIKAAADAVRRFHVQQGYRGYSVETWPGVTASRRAT 118

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGV 178
           PV +  LY+P GSAPL S+++MLA PA +AG  ++V+ +PP     +   +L AA L G+
Sbjct: 119 PVDTAALYVPAGSAPLVSSLIMLAIPAQLAGVPRIVVVAPPAGDGGVNPALLAAADLLGL 178

Query: 179 QDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSE 238
            +V+ +GGAQAIAAL+FG   +P+ DKIFGPGNA+V  AK  VS    G A+D+PAGPSE
Sbjct: 179 DEVYAIGGAQAIAALSFGAAGLPRADKIFGPGNAYVAAAKAYVSSLPGGPAVDLPAGPSE 238

Query: 239 VLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETA 298
           V+VIAD  A PD VASDLLSQAEH P +QV+L+   A  A RV  +V + L +LPRA  A
Sbjct: 239 VMVIADETADPDLVASDLLSQAEHDPSAQVMLVCFDAATADRVTASVAKLLEDLPRAAIA 298

Query: 299 RQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESA 358
           R+AL AS ++V   +   ++I+N Y PEHLI+Q  +A  L+  +  AGS+F+G W+PE+A
Sbjct: 299 REALAASAILVCDSVDDAIDIANIYAPEHLILQAESAERLLAGVRHAGSIFVGAWTPEAA 358

Query: 359 GDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTA 418
           GDYA+G NH LPT G       + +  FQK  T+   S+ G  ALA T+E LAA E+L A
Sbjct: 359 GDYAAGPNHTLPTAGAARAHGGVSVESFQKTTTILRASEAGAVALAPTVERLAALEQLDA 418

Query: 419 HKNAVTLRVNALKE 432
           H  A+ LR      
Sbjct: 419 HGLAMRLRRERANT 432


>UniRef50_A0R401 Histidinol dehydrogenase n=2 Tax=Actinomycetales RepID=A0R401_MYCS2
          Length = 451

 Score =  436 bits (1121), Expect = e-120,   Method: Composition-based stats.
 Identities = 152/419 (36%), Positives = 228/419 (54%), Gaps = 12/419 (2%)

Query: 24  PAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDE 83
           P       +   V+ +L +++ RG +A+R Y+ + D  +   L++ A+E+  + + L  +
Sbjct: 25  PPAQRDPKVVERVSQMLLDIERRGLDAVRAYARELDGWS-GPLEIGADELRKSGDALPAD 83

Query: 84  LKQAMAVAVKNIETFHTAQKLP--PVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFST 141
           L++A+ +  +    F  AQ+      ++E  PGV       PV  VG Y+P G  PL ++
Sbjct: 84  LREALELGYERTNRFAVAQRARLTDFEIELAPGVTGGVQYVPVNRVGAYLPAGRFPLLAS 143

Query: 142 VLMLATPASIAGCKKVVLCSPP----PIADEILYAAQLCGVQDVFNVGGAQAIAALAFGT 197
             M    A  AG   V+ C+PP         +LY A L     VF VGG QA+ A+AFG 
Sbjct: 144 AFMTVGVAKAAGVPTVLACTPPSGEHGAHPAVLYGAYLSRADSVFAVGGVQALGAMAFGL 203

Query: 198 ESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLL 257
                VD + G GNAFVTEAKRQ+  R+    ID+ AGPSEV V+AD  A P++VA+DLL
Sbjct: 204 IGDGPVDMLVGAGNAFVTEAKRQLFGRV---GIDLLAGPSEVAVLADETADPEWVAADLL 260

Query: 258 SQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL-NASRLIVTKDLAQC 316
            QAEHGP+S   L+T +  + RRV EA++RQL  L   E A  A  +   ++V  D  Q 
Sbjct: 261 GQAEHGPNSPAALITTSETLGRRVIEAIDRQLETLATREVAGPAWRDFGSVLVASDAEQA 320

Query: 317 VEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDY-ASGTNHVLPTYGYT 375
             I++  GPEHL +QT +    +  + + GS+FLG WS  +  D   +GTNHVLPT    
Sbjct: 321 AAIADVLGPEHLEVQTADDDYFLKRLRNYGSLFLGRWSTVAYSDKGIAGTNHVLPTGKTA 380

Query: 376 ATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNALKEQA 434
              + L ++ F K +T Q  ++E  +ALA  +E ++A E L AH+   T+R+  +   +
Sbjct: 381 RYNAGLSVSRFVKPLTYQRAAREATAALAPAVERISAFEGLAAHEATATIRIEEIGRDS 439


>UniRef50_C7RAI8 Histidinol dehydrogenase n=1 Tax=Kangiella koreensis DSM 16069
           RepID=C7RAI8_KANKD
          Length = 405

 Score =  436 bits (1121), Expect = e-120,   Method: Composition-based stats.
 Identities = 134/421 (31%), Positives = 216/421 (51%), Gaps = 22/421 (5%)

Query: 10  NSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVS 69
              +  +      RP ++ S  + + V  +L  ++  GD A+   S +FD      +++ 
Sbjct: 2   ADKSYIECASNWKRPNLTQSPELFQQVAKLLKEIETGGDLAIDNLSKRFDGFQPRKIELR 61

Query: 70  AEEIAAASERLSDELKQAMAVAVKNIETFHTAQK--LPPVDVETQPGVRCQQVTRPVASV 127
                     L  +L  ++  A + IE F   QK  L P  +E   GV   Q   P+ ++
Sbjct: 62  PYRDYE----LEPQLLNSIEQAAQRIEAFCQLQKGSLQPQQIEEASGVFGFQ-YSPIEAI 116

Query: 128 GLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVFNVGGA 187
           G YIPGG  PL ST LM   PA +AGC++ V CSP  +   IL AA L G  + + +GGA
Sbjct: 117 GAYIPGGRFPLISTALMTLIPARVAGCQRRVACSP-SVHPAILAAASLAGATEFWQIGGA 175

Query: 188 QAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGA 247
           QA+AA+A+G +++  V  + GPGN +V  AK+ +  R+    ID+ AGPSE+L++ADS A
Sbjct: 176 QAVAAMAYGYQTMLPVQMVVGPGNQYVNVAKQLLQSRIK---IDVAAGPSELLILADSNA 232

Query: 248 TPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAV--ERQLAELPRAETARQALNAS 305
             +++ +D+ +QAEH P +Q +L++      + + + +    +L  L + E         
Sbjct: 233 NQEWLIADMAAQAEHDPQAQSVLVSDDIAFLQSIGQQLTANDELNNLLKGEQI------- 285

Query: 306 RLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGT 365
            L+   D    +  SN+Y PEHL++   + R    S+   GS+F+G  S  + GDY +G 
Sbjct: 286 VLLQANDCEAMIRFSNRYAPEHLLL--ADERIASQSLKHYGSLFIGQNSAVAFGDYCAGP 343

Query: 366 NHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTL 425
           NH LPT G     S L +  F    + Q+++ +G   LA     LA AE+L  H+ ++ +
Sbjct: 344 NHTLPTMGSANRSSGLCVQSFMNIQSYQQINDQGRIQLAEIGRPLAEAEQLVWHERSMQV 403

Query: 426 R 426
           R
Sbjct: 404 R 404


>UniRef50_B1ZNB2 Histidinol dehydrogenase n=3 Tax=Verrucomicrobia RepID=B1ZNB2_OPITP
          Length = 431

 Score =  429 bits (1104), Expect = e-119,   Method: Composition-based stats.
 Identities = 152/433 (35%), Positives = 233/433 (53%), Gaps = 14/433 (3%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
             I+   S T +       R  +     IT +V  IL +V+ RGDEA+  Y+AKFD   +
Sbjct: 1   MRILHHASKTFDADVADFCRTTM-VPREITESVAAILADVRERGDEAVVYYAAKFDGAKL 59

Query: 64  T--ALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVT 121
               L+V   ++  A++RL    ++A+  A  +I  ++          +   G    +  
Sbjct: 60  RARDLRVKPSDLTVAAKRLPAAERRALVAARDSIMDYNRRGLPRGWTAKNPHGAMVGEKF 119

Query: 122 RPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSP----PPIADEILYAAQLCG 177
            P+  VGLY+PGG  PL STVLM  T A IA C +VV+ +P      IAD +L A  L G
Sbjct: 120 DPLRRVGLYVPGGQVPLVSTVLMTVTLAKIAQCPQVVVFTPCNAEGKIADGLLAALHLLG 179

Query: 178 VQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPS 237
           V +V+ VGG QAI A+AFGT ++P VDKIFGPGNA+  EA RQV   +    ++   GPS
Sbjct: 180 VDEVYRVGGVQAIGAMAFGTTTIPPVDKIFGPGNAYTCEAMRQVFGIV---GVNGLPGPS 236

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPD-SQVILLTPAADMARRVAEAVERQLAELPRAE 296
           E++VIAD  A  D+ A+DLL+QAEHG    +V L+  ++ +   +   +  QL  L R+E
Sbjct: 237 ELMVIADDTARADYAAADLLAQAEHGSGREKVYLVATSSRVITEIVNEMNGQLQTLTRSE 296

Query: 297 TARQALNASRL-IVTKDLAQCVEISNQYGPEHLIIQTRNA--RELVDSITSAGSVFLGDW 353
             ++ L    L I    + Q   ++N   PEHL +    A  ++L  ++T+AG++ +G+ 
Sbjct: 297 KTQRVLEQGFLAIEVGSMQQAAAVANYVAPEHLELLVSEAAVKQLTKAVTTAGAIMIGNE 356

Query: 354 SPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAA 413
           +P + GD+ +G +HVLPT       S + ++DF +R ++    ++     A  +   AA 
Sbjct: 357 TPTALGDFTAGPSHVLPTGRAGRFFSGMRVSDFLRRTSLVRYDRKSVRKGAPVVAAFAAM 416

Query: 414 ERLTAHKNAVTLR 426
           ERL AH  +V +R
Sbjct: 417 ERLDAHGRSVKIR 429


>UniRef50_C1A4M1 Histidinol dehydrogenase n=1 Tax=Gemmatimonas aurantiaca T-27
           RepID=C1A4M1_GEMAT
          Length = 816

 Score =  422 bits (1086), Expect = e-116,   Method: Composition-based stats.
 Identities = 154/430 (35%), Positives = 237/430 (55%), Gaps = 15/430 (3%)

Query: 8   DWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALK 67
            W+      +R L  R A +   +I    + ++D V+  GD AL + + +FD  T+  L+
Sbjct: 12  SWDRLDNATRRALEDR-ASTVDPTIRERTSAVIDAVRRTGDAALIDMARRFDGATLETLE 70

Query: 68  VSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASV 127
           V   E   A   L   L+Q++  A +NI T H A          +PG+   +   P+  V
Sbjct: 71  VPRAEWDRALAALDPALRQSLERAARNIATVHRAFLPTITRSTPEPGITVVRRPDPLGRV 130

Query: 128 GLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIA----DEILYAAQLCGVQDVFN 183
           G+Y PGG A   S++LM A PA +AG  ++++C+PP       D +L AA L  V  VF 
Sbjct: 131 GIYAPGGRAAYPSSLLMGAVPARVAGVGEIIVCTPPGPDGRPADVVLAAAALANVDRVFA 190

Query: 184 VGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIA 243
           VGGA AIAA+A GT SVP+VD+I GPGNA+V EAK Q+   +   AID PAGPSE+LV+A
Sbjct: 191 VGGAGAIAAMALGTASVPRVDRIMGPGNAYVAEAKLQL---VSAVAIDAPAGPSELLVLA 247

Query: 244 DSGATPDFVASDLLSQAEHGPDSQVILLTPA----ADMARRVAEAVERQLAELPRAETAR 299
           D+ A  + +A ++L+QAEH PD+ V+ +       + +A RV  A++ QLA  PRA+  R
Sbjct: 248 DASADANTIAREMLAQAEHDPDAAVLAVIVDHSATSSLATRVETALQTQLASAPRADVMR 307

Query: 300 QAL-NASRLIVTKDLAQCVEISNQYGPEHLIIQTRNA--RELVDSITSAGSVFLGDWSPE 356
            AL     ++    + + +  +N++  EHL++   +     ++ ++ +AG++F+G  S  
Sbjct: 308 AALGARGGVVHMTSMDEAITFANRWAAEHLLLLVDDTQRDRVLAALRNAGTIFVGASSSV 367

Query: 357 SAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERL 416
           + GDY +G NHVLPT G   + S L   DF +  T QE++    ++L++ +   A AE L
Sbjct: 368 AFGDYMTGANHVLPTAGAARSYSGLSTLDFVRWTTWQEVTPAAAASLSADVGRFADAEGL 427

Query: 417 TAHKNAVTLR 426
            AH       
Sbjct: 428 PAHAATARTW 437


>UniRef50_C9SQK1 Histidine biosynthesis trifunctional protein n=1 Tax=Verticillium
           albo-atrum VaMs.102 RepID=C9SQK1_VERA1
          Length = 699

 Score =  420 bits (1080), Expect = e-116,   Method: Composition-based stats.
 Identities = 160/439 (36%), Positives = 223/439 (50%), Gaps = 79/439 (17%)

Query: 2   SFNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKT 61
                 D +  +A +  ++L RP+  + E+I   V  I+D V++ GD+A+  Y+ KF+K 
Sbjct: 333 ILMRRYDASKVSAAEVTEVLKRPSQKSPEAILNIVKPIIDEVRSGGDKAVLSYTHKFEKA 392

Query: 62  TVTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKL-PPVDVETQPGVRCQQV 120
           T     V        + +LS E  +A+ ++ +NI  FH AQK   P+ VET PGV C ++
Sbjct: 393 TSLTSPVLRAPFPEEAMKLSKESIKAIDISFENIRKFHAAQKEDKPLHVETMPGVVCSRM 452

Query: 121 TRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIA----DEILYAAQLC 176
           +RP+  VGLYIPGG+A L ST LML  PA +AGCKK+V  SPP        EI+Y A   
Sbjct: 453 SRPIERVGLYIPGGTAVLPSTALMLGVPAMVAGCKKIVFASPPRADGSLTPEIVYVAHKV 512

Query: 177 GVQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLD-GAAIDMPAG 235
           G + +   GGAQA+AALA+GTESVPKVDKI GPGN FVT AK  VS   + G +IDMPAG
Sbjct: 513 GAESIVLAGGAQAVAALAYGTESVPKVDKILGPGNQFVTAAKMFVSNDTNAGVSIDMPAG 572

Query: 236 PSEVLVIADS-GATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPR 294
           PSEV  I ++   + D+    L+ Q ++ P                              
Sbjct: 573 PSEVRDIDEAMRISNDYAPEHLILQLKNAP------------------------------ 602

Query: 295 AETARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWS 354
            E A+  +NA  +                                         F+G+W+
Sbjct: 603 -EVAQMVMNAGSI-----------------------------------------FIGEWT 620

Query: 355 PESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAE 414
           PES GDY++G NH LPTYG+    S + L  F K +T   L+ EG   + S +  LA  E
Sbjct: 621 PESVGDYSAGVNHSLPTYGFAKQYSGVNLGSFVKHITSSNLTAEGLRNVGSAVMQLAKVE 680

Query: 415 RLTAHKNAVTLRVNALKEQ 433
            L AH+ AV +R+N L ++
Sbjct: 681 ELEAHRRAVEIRLNYLDKK 699


>UniRef50_B5YLM0 Histidinol dehydrogenase n=1 Tax=Thalassiosira pseudonana CCMP1335
           RepID=B5YLM0_THAPS
          Length = 441

 Score =  408 bits (1050), Expect = e-112,   Method: Composition-based stats.
 Identities = 139/397 (35%), Positives = 203/397 (51%), Gaps = 22/397 (5%)

Query: 49  EALREYSAKFDKTTV--TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPP 106
           +AL   + +        ++  VS+ +   A + LSDE ++++      ++ F  AQ+   
Sbjct: 48  KALISIARRLSDILPASSSYTVSSAQCKEAFDSLSDEDRRSLLNIHARVKLFADAQRGSV 107

Query: 107 VDVE-TQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPI 165
           VDVE   PG +      P  + G Y PGG  PL S+VLM    A  AGC  VVL SP   
Sbjct: 108 VDVEVDIPGGKAGHTVSPCRAAGCYAPGGRYPLPSSVLMTVVTARSAGCPYVVLASP-RP 166

Query: 166 ADEILYAAQLCGVQDVFNVGGAQAIAALAFGTE------------SVPKVDKIFGPGNAF 213
           A   L AA + G   V  VGGAQAI  +A+G +            ++P  D I GPGN +
Sbjct: 167 APITLAAAHVAGADVVLCVGGAQAIGCMAYGVDEYDGEDGGTKVDAIPACDVIVGPGNKW 226

Query: 214 VTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILLTP 273
           VT AK  V+       IDM AGPSEVLVI D  A  + VA+DL++QAEH   ++ IL++ 
Sbjct: 227 VTAAKSIVNGH---CGIDMLAGPSEVLVICDHTANAEIVAADLIAQAEHDVVARAILVSD 283

Query: 274 AADMARRVAEAVERQLAELP--RAETARQALNASRLIVTKDLAQCVEISNQYGPEHLIIQ 331
              +  +V + VE+Q+  LP     TA++AL  S  I+ KD+ +C+ +S++  PEHL IQ
Sbjct: 284 DKTVIDKVDQEVEKQVECLPEPNRSTAKEALKQSFSILCKDIDECIAMSDKLAPEHLEIQ 343

Query: 332 TRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMT 391
           T N++ +    ++ G +F+G  + E  GDY +G NH LPT G       L + +F +  T
Sbjct: 344 TLNSQSVGMKCSNYGGLFIGTHAAEVLGDYGAGPNHTLPTGGTGRYTGGLSVFNFLRIRT 403

Query: 392 VQELSKEG-FSALASTIETLAAAERLTAHKNAVTLRV 427
              + +EG    +      +A  E L  H  A   R 
Sbjct: 404 WMRIDEEGKSQEMVEDSVRMARLEGLEGHARAAEKRR 440


>UniRef50_UPI0001C3165E histidinol dehydrogenase n=1 Tax=Conexibacter woesei DSM 14684
           RepID=UPI0001C3165E
          Length = 426

 Score =  390 bits (1003), Expect = e-107,   Method: Composition-based stats.
 Identities = 145/414 (35%), Positives = 206/414 (49%), Gaps = 18/414 (4%)

Query: 22  MRPAISASESITRTVNDILDNVKARGDEALREYSAKFD--KTTVTALKVSAEEIAAASER 79
           +R  + A+ SI   V  I+ +V+ RGD A+ E +   D       AL+VS  E+ AA + 
Sbjct: 21  LRRLVPAAASIADPVAAIVADVRDRGDAAVLELTRAHDTGGAEPKALRVSQSELDAALDS 80

Query: 80  LSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLF 139
           L  +++  + VA +N+            +V    G   +    PV    +Y+PGG AP  
Sbjct: 81  LDADVRAGLEVAAQNVGVVAAIGLDDEREVTLGHGQTVRLREVPVRRAAVYVPGGRAPYP 140

Query: 140 STVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQDVFNVGGAQAIAALAF 195
           STVLM    A  AG ++VVLCSPP     +   IL AA L G  +V+ +GGAQAI ALA 
Sbjct: 141 STVLMGVVTAVTAGVEEVVLCSPPGPDGDLNPAILAAAALAGATEVYRMGGAQAIGALAH 200

Query: 196 GTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASD 255
           GT +V  VD I GPGN +V EAKRQVS       ID  AGPS+++V+ D GA     A D
Sbjct: 201 GTATVAPVDLIVGPGNLWVQEAKRQVSA-AGLVGIDGFAGPSDLMVVLDRGADVRLAALD 259

Query: 256 LLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQ 315
           L +QAEHG DS V+ ++P           +   L+ +P             L+ T  L  
Sbjct: 260 LRAQAEHGSDSLVLAVSPDGAALDA----LSEGLSVVPEPGV-------GALVETASLED 308

Query: 316 CVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYT 375
            + ++N + PEHL +    A  L   + +AG +F+G     + GDY +G+NH LPT G  
Sbjct: 309 ALALANAFAPEHLELIGAGAEALAPEVRNAGCLFVGPGGATAFGDYVAGSNHTLPTDGAA 368

Query: 376 ATCSSLGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNA 429
              S L    F++RMT   +  E  + LA     +A AE    H  ++  R+  
Sbjct: 369 RFASGLSARHFRRRMTEVRIPLEAATTLAPAGAAIARAEGFELHAQSMEARMRE 422


>UniRef50_C6UN35 Histidinal/histidinol dehydrogenase n=1 Tax=Candidatus Hodgkinia
           cicadicola Dsem RepID=C6UN35_HODCD
          Length = 428

 Score =  388 bits (997), Expect = e-106,   Method: Composition-based stats.
 Identities = 138/430 (32%), Positives = 204/430 (47%), Gaps = 11/430 (2%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
            +  +  +S    +  + ++      S  +      I   V A  D+AL  Y+ + D   
Sbjct: 1   MSLRLRSDSPGFGEFVKGVIASRARVSARVKAVAEKISQTVSAYADKALMAYNLRLDGCA 60

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
              L+ +  +I    E +  +   ++ +A+  +   H+ Q      V    G +      
Sbjct: 61  SRLLRFAP-DID--LETVDVKALFSLKLALDRVAALHSLQLPSSCCVRDALGAKLGFRWT 117

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPI---ADEILYAAQLCGVQ 179
           PV+SVG+Y+PGG+A   S+V+M   PA IAG   + L +P          +  A+LCGV 
Sbjct: 118 PVSSVGVYVPGGTASYLSSVIMCCVPARIAGVGHISLATPYSKLANKPLFMACAKLCGVA 177

Query: 180 DVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEV 239
            V+  GGA A+AAL+ GT +V KVDKI GPGNAFV  AK     R+    +D  AGPSE 
Sbjct: 178 CVYPFGGAHAVAALSVGTRAVRKVDKIVGPGNAFVAAAKALAQGRV---GVDCLAGPSEA 234

Query: 240 LVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETAR 299
           +++AD  A    +A D L Q EH  D+   ++  +A++A RV   V   +    R  TA 
Sbjct: 235 VIVADGVADAWTLAVDSLCQLEHASDALTAVVVSSAELASRVRANVALLVRSARRRRTAE 294

Query: 300 QALNASRL-IVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESA 358
           ++ +A  + +V   +A      N    EH+        +L+  +TSAG+VFLG  SP   
Sbjct: 295 RSWSAGGVSVVCCCVADAAATVNALASEHVQACVLKPAKLLTKLTSAGAVFLGGGSPIVV 354

Query: 359 GDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQEL-SKEGFSALASTIETLAAAERLT 417
           GDY  GTNH LPT       S L + DF KR  V  L +     ALA      A+AE L+
Sbjct: 355 GDYVGGTNHTLPTASGAKFASGLSVLDFMKRTYVTWLPTARPMLALAPACAACASAEGLS 414

Query: 418 AHKNAVTLRV 427
            H  A   R+
Sbjct: 415 CHALASASRL 424


>UniRef50_A8M914 Histidinol dehydrogenase n=1 Tax=Caldivirga maquilingensis IC-167
           RepID=A8M914_CALMQ
          Length = 399

 Score =  382 bits (981), Expect = e-104,   Method: Composition-based stats.
 Identities = 131/414 (31%), Positives = 209/414 (50%), Gaps = 31/414 (7%)

Query: 21  LMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERL 80
           L+R A    + +   V  I+++VK  GDEAL   +++ D   ++++++S  E+ A +  +
Sbjct: 11  LLRKATDMDQYV-DRVRGIINDVKEHGDEALLRLTSELDGVKLSSIELSQSELRALASGI 69

Query: 81  SDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFS 140
              +++A+   + ++E+F+T  K    +   + G+R      P++ VGLY+P G    FS
Sbjct: 70  EPRVREALDEVMASVESFNTGVKPRDFEDYHR-GLRRGVKWVPLSRVGLYVPKG---YFS 125

Query: 141 TVLMLATPASIAGCKKVVLCSPPP----IADEILYAAQLCGVQDVFNVGGAQAIAALAFG 196
           T++M    A +AG ++++  +PP     I  EI Y A       VF VGGAQA+AALAFG
Sbjct: 126 TLVMTGVLAKVAGVEEIIAVTPPRRDGLIDPEIAYVALRLNA-RVFRVGGAQAVAALAFG 184

Query: 197 TESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDL 256
           TESVP+VDKI GPGNA+V  AK  VS  +    ID   GP+E++  AD G  P  VA DL
Sbjct: 185 TESVPRVDKIIGPGNAYVQAAKLLVSSHV---GIDGVEGPTELVTCADPGIKPITVALDL 241

Query: 257 LSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQC 316
            +Q EH   +  +++T +      + + + + L   P               +  + ++C
Sbjct: 242 AAQLEHA-GAVGVVVTWSEGYLTAIEDELSK-LTNAP-----------YFSTLVNEPSEC 288

Query: 317 VEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTA 376
           V + N+  PEH  I     +  ++ I +AG+V +   +P +  DYA+G +HVLPT G   
Sbjct: 289 VNVINEVAPEHASIW--GVKIPIEGIRNAGAVSI--MAPSALVDYAAGPSHVLPTGGSAR 344

Query: 377 TCSSLGLADFQKRMTVQE-LSKEGFSALASTIETLAAAERLTAHKNAVTLRVNA 429
               L   DF K +   E  S +    L      L   E    H  A+T  +N 
Sbjct: 345 WRGVLTPMDFMKPIAYVEPTSGDEARRLGELGAVLGLREGFRRHSEALTNWINE 398


>UniRef50_B7FPZ7 Histidinol dehydrogenase (Fragment) n=3 Tax=Eukaryota
           RepID=B7FPZ7_PHATR
          Length = 347

 Score =  379 bits (975), Expect = e-104,   Method: Composition-based stats.
 Identities = 134/338 (39%), Positives = 182/338 (53%), Gaps = 10/338 (2%)

Query: 95  IETFHTAQKLPPVDVE-TQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLMLATPASIAG 153
           +  F T Q+   VD E   PG +  Q  RP  + G Y PGG  PL S+V+M A  A  AG
Sbjct: 1   VLAFATMQRSSVVDKEMDIPGGKAGQTVRPCGAAGCYAPGGRYPLPSSVIMTAVTARAAG 60

Query: 154 CKKVVLCSPPPIADEILYAAQLCGVQDVFNVGGAQAIAALAFGT--ESVPKVDKIFGPGN 211
           C+ VVL SP   A   L AA L G      VGGAQAIA++A+G     VP+ D I GPGN
Sbjct: 61  CETVVLSSP-KPAPITLAAAYLSGADHFLCVGGAQAIASMAYGIVDSDVPRCDVICGPGN 119

Query: 212 AFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGPDSQVILL 271
            +VT AK  V+       IDM AGPSEVLVI D  A P+ VA+DL++QAEH   ++ ILL
Sbjct: 120 KWVTAAKSIVNGH---CGIDMLAGPSEVLVICDDTANPEIVAADLIAQAEHDVVARAILL 176

Query: 272 TPAADMARRVAEAVERQLAELP--RAETARQALNASRLIVTKDLAQCVEISNQYGPEHLI 329
           + +  +  +V E V +Q+  LP     TA +AL  S  +  + L QC+ IS+   PEHL 
Sbjct: 177 STSDAIIEQVDENVSKQIEALPEPNRSTALEALKQSFAVKCESLEQCIAISDDIAPEHLE 236

Query: 330 IQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKR 389
           IQTR+A ++ ++  + G +F+G+ + E  GDY +G NH LPT G       L + +F + 
Sbjct: 237 IQTRDAMKVGEACNNYGGLFIGEHAAEVLGDYGAGPNHTLPTGGTGRYTGGLSVFNFLRV 296

Query: 390 MTVQELS-KEGFSALASTIETLAAAERLTAHKNAVTLR 426
            T   +        + +    +A  E L  H  A   R
Sbjct: 297 RTWMRVDNAAASQTMVNDSIIMARLEGLEGHARAAETR 334


>UniRef50_A8A9G5 Histidinol dehydrogenase n=1 Tax=Ignicoccus hospitalis KIN4/I
           RepID=A8A9G5_IGNH4
          Length = 404

 Score =  344 bits (883), Expect = 4e-93,   Method: Composition-based stats.
 Identities = 126/410 (30%), Positives = 195/410 (47%), Gaps = 34/410 (8%)

Query: 23  RPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSD 82
           R ++   E + + V  ++  VKARG EA+++Y+  FD      + +S E+ A+ S+   +
Sbjct: 26  RGSLDLWEYVEK-VMPVVKEVKARGLEAVKKYNKAFDNYE-GCVSLSQEDFASYSK---E 80

Query: 83  ELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTV 142
            L       ++ +  FH           +  GVR   + RPV  +G Y+PGG  P  ST 
Sbjct: 81  SLVSLFEEVLEQLSAFHKQTAPKD-SAFSSKGVRAVTLWRPVERLGAYVPGGLYPYPSTA 139

Query: 143 LMLATPASIAGCKKVVLCSPPPIA-DEILYAAQLC-GVQDVFNVGGAQAIAALAFGTESV 200
           LM A  A   G K+V + +PP  A  E++ +A L   V  V   GGA  ++ALA+    V
Sbjct: 140 LMTAGVAKALGVKEVTVATPPKFATSEVMASAFLASKVDSVLAAGGAHGVSALAY----V 195

Query: 201 PKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQA 260
               K+ GPG  +V  AK  VS  +    IDM AGP+E+ VIADS A P+ VA D+L+QA
Sbjct: 196 AGAHKVVGPGGPYVQAAKLLVSVDVP---IDMIAGPTELAVIADSSADPEEVAYDMLAQA 252

Query: 261 EHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQCVEIS 320
           EHGP S  +L++    +   V + V+             +        V +DL +   + 
Sbjct: 253 EHGPTSFALLVSTDEGLVLEVEKRVK-----------GEEVEGGLYATVVRDLEEAKRLV 301

Query: 321 NQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSS 380
           ++  PEH+ +        V     AG+      +P    DY++G NHVLPT G+      
Sbjct: 302 SELAPEHVSVYAETYEPPV-----AGAASF--KAPSPFLDYSAGPNHVLPTSGWAKARGP 354

Query: 381 LGLADFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVTLRVNAL 430
           LG  DF +  T+ E+  E  + L      LA  E +  H  A+  +++ +
Sbjct: 355 LGPVDFMRWTTLVEVFPEA-ADLLKLAAELARLEGMKYHAKAIEYKLSKI 403


>UniRef50_B9NIZ3 Histidinol dehydrogenase n=1 Tax=Populus trichocarpa
           RepID=B9NIZ3_POPTR
          Length = 394

 Score =  332 bits (851), Expect = 2e-89,   Method: Composition-based stats.
 Identities = 112/275 (40%), Positives = 157/275 (57%), Gaps = 12/275 (4%)

Query: 7   IDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVT-- 64
           +       E      +  +     +I + V DIL +V+ RGD A+ EY+A+FD   V   
Sbjct: 114 LSTADANFEHDFAQRLHWSADTDAAIEQRVADILADVQKRGDAAVLEYTARFDGLQVEGM 173

Query: 65  -ALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKL---PPVDVETQPGVRCQQV 120
            AL+++  E+ AA + L DE + A+  A + + T+H AQK             G    Q 
Sbjct: 174 AALELTQAELKAAFDSLGDEQRDALTAAAQRVRTYHEAQKRASGESWSYRDADGTLLGQK 233

Query: 121 TRPVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCG 177
             P+  VG+Y+PGG A   S+VLM A PA +AG +++++  P P       +L AA + G
Sbjct: 234 VTPLDRVGIYVPGGKAAYPSSVLMNAIPAHVAGVQEIIMVVPTPRGEKNALVLAAAYVAG 293

Query: 178 VQDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPS 237
           V   F +GGAQA+AALA+GT ++PKVDKI GPGNA+V  AK++V   +    IDM AGPS
Sbjct: 294 VTRGFTIGGAQAVAALAYGTATIPKVDKITGPGNAYVASAKKRVFGTV---GIDMIAGPS 350

Query: 238 EVLVIADSGATPDFVASDLLSQAEHGPDSQVILLT 272
           E+LV+AD    PD+VA DL SQAEH   +Q ILL 
Sbjct: 351 EILVLADGSTPPDWVAMDLFSQAEHDELAQSILLC 385


>UniRef50_P72946 Putative histidinol dehydrogenase 2 n=1 Tax=Synechocystis sp. PCC
           6803 RepID=HISX2_SYNY3
          Length = 409

 Score =  327 bits (840), Expect = 4e-88,   Method: Composition-based stats.
 Identities = 100/394 (25%), Positives = 167/394 (42%), Gaps = 20/394 (5%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              +I  +    ++ R+L  RP  S    + + V             A  E+ A  D   
Sbjct: 1   MLRLITQSGDIVQELRRLHHRPVPSPWPVMAQVV-------------AAMEHWAAMD--Q 45

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
               +VS  E+ AA +R+S E    +  A   +E  +  Q         + G    Q   
Sbjct: 46  DAPPRVSGAELDAAYQRISQEKLSVIRQACAALEQVYRPQLPKTQVSFPEDGTVRGQRFY 105

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIADEILYAAQLCGVQDVF 182
           PV   G Y+          +L     A   G  + VL +   I+  IL AAQ  G+++++
Sbjct: 106 PVRRAGFYLEAKRGDALGNLLRQGMLAKTVGVAERVLVTE-TISSTILVAAQEMGIEEIY 164

Query: 183 NVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVI 242
              G  AIA L +G +++  V+ I G G   V  AK+ VS  +    ID     + ++V+
Sbjct: 165 LAAGVPAIAMLTWGAKNIAPVESITGAGCPRVMAAKQLVSGVV---TIDQTLARTNLMVL 221

Query: 243 ADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETARQAL 302
           AD  A   ++A DLL+ AE  P++  +LLT   ++   V ++V R   E   +    +AL
Sbjct: 222 ADGEANGQWLALDLLAHAEQYPNASAVLLTDRLELGEEVIQSVNRYCREQEHSVHTEKAL 281

Query: 303 NASRLI-VTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDY 361
               L+ + +DL  C    N++ P  L++   +   +V+ +  A  +++G  SP   G Y
Sbjct: 282 AHYGLVAIVEDLEACGSWINEFCPHILLLAMEDPWTMVEKVQRAREIYIGHRSPSILGHY 341

Query: 362 ASGTNHVLPTYGYTATCSSLGLADFQKRMTVQEL 395
            SG N +    G  AT S L    F +   + + 
Sbjct: 342 LSGANRLQTQDGAMATASELAFHCFLRSSQLLDY 375


>UniRef50_Q8ZY17 Histidinol dehydrogenase n=5 Tax=Thermoproteaceae RepID=HISX_PYRAE
          Length = 368

 Score =  298 bits (764), Expect = 2e-79,   Method: Composition-based stats.
 Identities = 108/400 (27%), Positives = 179/400 (44%), Gaps = 34/400 (8%)

Query: 26  ISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASERLSDELK 85
                 +  +V  I+D+V++ G +A  EYS + D        V+  +          E+ 
Sbjct: 2   RGFPREVLESVWKIVDDVQSGGLKAALEYSKRLDGVAPEPHLVTPRQ------GGDPEVV 55

Query: 86  QAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSAPLFSTVLML 145
            A   A K++E  ++    P   V+   G+  Q + +PV    LY+P   A   ST++ML
Sbjct: 56  SAALAAAKSLEALYSRISPPA-AVDFYGGILRQILWKPVRRAALYVP---ARYISTLVML 111

Query: 146 ATPASIAGCKKVVLCSPP-PIADEILYAAQLCGVQDVFNVGGAQAIAALAFGTESVPKVD 204
           A PA +AG ++V + +PP  +++E+L  A+  GV+ V  +GG   +A   F       VD
Sbjct: 112 AVPARLAGVEEVYVVTPPRGVSEELLAVAKELGVKAVLALGGPHGLAYAVFHM----GVD 167

Query: 205 KIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSGATPDFVASDLLSQAEHGP 264
            + GPG  +V  AK  +SQ +    ID   GP+E+++ A  G  P+      L+Q EHGP
Sbjct: 168 VVAGPGGLYVQAAKYILSQYV---GIDGIEGPTELVIYA-EGVPPEVAVRGALAQLEHGP 223

Query: 265 DSQVILLTPAADMARRVAEAVERQLAELPRAETARQALNASRLIVTKDLAQCVEISNQYG 324
            S   LL+P  ++ ++  E   R+            ++   ++     + + V   ++  
Sbjct: 224 TSFAYLLSPDGELLKKAEELYVRERT---------SSMGPLKVKKVGGIDEAVSFIDEIA 274

Query: 325 PEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLA 384
           PEHL +  R  RE+   + + G+V +    P    DY +G +HVLPT G       +   
Sbjct: 275 PEHLEVWGR--REVAYRVRNVGAVSVNM--PSPYLDYVAGISHVLPTGGTARWRGVITPL 330

Query: 385 DFQKRMTVQELSKEGFSALASTIETLAAAERLTAHKNAVT 424
            F K + + E   E    L      LA  E    H  A+ 
Sbjct: 331 AFMKPIGIAEAVGE--LTLREAARKLAEYEGFKYHGEALR 368


>UniRef50_B8NVQ6 Histidinol dehydrogenase, putative n=1 Tax=Aspergillus flavus
           NRRL3357 RepID=B8NVQ6_ASPFN
          Length = 224

 Score =  226 bits (576), Expect = 2e-57,   Method: Composition-based stats.
 Identities = 78/247 (31%), Positives = 113/247 (45%), Gaps = 39/247 (15%)

Query: 187 AQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVIADSG 246
             A+AA+A GTE++ KVD + G GN FV E KRQ+   +    ID+ AGP+EVLV+AD  
Sbjct: 11  VPAVAAIAVGTETIRKVDFLAGTGNRFVAEGKRQLFGEV---GIDLFAGPTEVLVLADET 67

Query: 247 ATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLA--ELPRAETARQALNA 304
           A P  VA DL+SQA HGPD+  +L+T    + R   E V + L+  +L   + A+ + +A
Sbjct: 68  ADPFTVAMDLISQAGHGPDTPAVLITTCPKVGRETIEIVNKLLSATDLSTPDVAKVSWDA 127

Query: 305 -SRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDSITSAGSVFLGDWSPESAGDYAS 363
              +I+   L +  E+ + Y  E + +                                 
Sbjct: 128 FGEVIIVDTLEELWELGDHYASEQVQVI-------------------------------- 155

Query: 364 GTNHVLPTYGYTATCSSLGLADFQKRMTVQELS-KEGFSALASTIETLAAAERLTAHKNA 422
           GTNH+LPT         L +  + K  T QE++  E    L       A  ER  A   +
Sbjct: 156 GTNHILPTRTTARYTGGLWVGKYLKTCTYQEVTLPESSGKLGRLCGRAARPERFEAPARS 215

Query: 423 VTLRVNA 429
             LR N 
Sbjct: 216 GDLRANR 222


>UniRef50_UPI0001909A69 histidinol dehydrogenase n=1 Tax=Rhizobium etli IE4771
           RepID=UPI0001909A69
          Length = 287

 Score =  211 bits (539), Expect = 3e-53,   Method: Composition-based stats.
 Identities = 65/178 (36%), Positives = 94/178 (52%), Gaps = 6/178 (3%)

Query: 20  LLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTVTA---LKVSAEEIAAA 76
           L +      SE +      I+D+VKARGD AL    A   +   +    ++V+ EEI AA
Sbjct: 31  LFLTTKREVSEDVNAVARAIIDDVKARGDVALCRIFADIRRHRFSPPVPMRVTPEEIDAA 90

Query: 77  SERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPVASVGLYIPGGSA 136
            E +  E+  A+ +A   IE+ H  Q       E   GVR       + +VGLY+PGG+A
Sbjct: 91  VEAVPSEVLGALKLAALRIESHHRRQLPKDDIYEDDLGVRLGSRWTAIEAVGLYVPGGTA 150

Query: 137 PLFSTVLMLATPASIAGCKKVVLCSPPP---IADEILYAAQLCGVQDVFNVGGAQAIA 191
              S+VLM A PA +AG  ++V+  P     +   +L AA+L GV +++ VGGAQAIA
Sbjct: 151 SYPSSVLMNAVPAKVAGVDRIVIAVPATGGAVNPAVLAAARLAGVTEIYRVGGAQAIA 208


>UniRef50_C5GHZ5 Histidinol dehydrogenase n=2 Tax=Ajellomyces dermatitidis
           RepID=C5GHZ5_AJEDR
          Length = 281

 Score =  211 bits (537), Expect = 6e-53,   Method: Composition-based stats.
 Identities = 71/270 (26%), Positives = 115/270 (42%), Gaps = 63/270 (23%)

Query: 65  ALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRPV 124
           + K+S  +I AA  ++S++  + +  A  N                         +   V
Sbjct: 2   SFKLSEGDIEAAVVKVSEQTIKDIKEAQAN-----------------------GYIW--V 36

Query: 125 ASVGLYIPGGSAPLFSTVLMLATP---ASIAGCKKVVLCSPP---PIADEILYAAQLCGV 178
             + L +  G   L S+          + +AG   V +C+PP    I +       L G 
Sbjct: 37  RRIFLLVQLGRRFLPSSFHTQEVQFCNSKVAGVNHVTMCTPPINGKIPNATTATTHLVGA 96

Query: 179 QDVFNVGGAQAIAALAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSE 238
            ++F +GGAQAIA +A GTES+ KVD I   G                   +D+ AGP+E
Sbjct: 97  NEIFILGGAQAIAGMAVGTESIRKVDSIAEIG-------------------VDLFAGPTE 137

Query: 239 VLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETA 298
           V             A+ LLSQAEHGPDS  +L+T + D A++V   ++R L  L  A  A
Sbjct: 138 V------------PATHLLSQAEHGPDSPAVLITTSEDSAKQVMTLIDRFLETLSTAAIA 185

Query: 299 RQAL-NASRLIVTKDLAQCVEISNQYGPEH 327
             A  +   +++   + +   + ++Y  +H
Sbjct: 186 STAWRSFREVVIVDSIDEAYALGDEYAFDH 215


>UniRef50_C7H2J0 Histidinol dehydrogenase n=1 Tax=Faecalibacterium prausnitzii
           A2-165 RepID=C7H2J0_9FIRM
          Length = 162

 Score =  207 bits (527), Expect = 7e-52,   Method: Composition-based stats.
 Identities = 50/164 (30%), Positives = 82/164 (50%), Gaps = 4/164 (2%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              + +++    E+     +R   +    +   V+ I+  V+ARGDEAL+EY+ KFD   
Sbjct: 1   MIKLYNFDELRPEEILNRDIRAEKN----VEDVVDGIIAEVRARGDEALKEYALKFDGAK 56

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
           +  L+V+  EI  A   +     + +  A  NIE+FH  Q      +  +PG+   Q   
Sbjct: 57  IDDLQVTQAEIDEAFANMDPYFLETLREAAANIESFHRQQVHKNFVINEKPGIVLGQKYT 116

Query: 123 PVASVGLYIPGGSAPLFSTVLMLATPASIAGCKKVVLCSPPPIA 166
           P+   G+Y+PGG+A   STVLM   PA +AG  ++V+ +P    
Sbjct: 117 PIEKAGVYVPGGTAAYPSTVLMDVIPAKVAGVSEIVMTTPAGKD 160


>UniRef50_A3J633 Histidinol dehydrogenase (Fragment) n=1 Tax=Flavobacteria bacterium
           BAL38 RepID=A3J633_9FLAO
          Length = 136

 Score =  158 bits (400), Expect = 4e-37,   Method: Composition-based stats.
 Identities = 57/140 (40%), Positives = 83/140 (59%), Gaps = 4/140 (2%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
              I +      E   ++  RP  + S  +  TV  I   V+ +G++A+ +Y++ FD  T
Sbjct: 1   MKKIYN---PQPETWLEICKRPTQTFS-DVEETVKQIFKKVQQKGNKAIAKYTSFFDGVT 56

Query: 63  VTALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTR 122
           +  ++V+ EEI  A + ++ ELK+A+ +A  NIE FH AQK   + VET  GV C Q  R
Sbjct: 57  LENIQVTPEEIELAKKEVATELKKAIQLAKSNIEQFHAAQKTDKIVVETTIGVTCWQEKR 116

Query: 123 PVASVGLYIPGGSAPLFSTV 142
           P+  VGLYIPGG+APLFSTV
Sbjct: 117 PIQKVGLYIPGGTAPLFSTV 136


>UniRef50_B4CYY3 NAD+ oxidoreductase n=1 Tax=Chthoniobacter flavus Ellin428
           RepID=B4CYY3_9BACT
          Length = 162

 Score =  142 bits (359), Expect = 2e-32,   Method: Composition-based stats.
 Identities = 40/147 (27%), Positives = 68/147 (46%), Gaps = 9/147 (6%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
              +  NS   +     L R A +    + +TV D+L+ ++  GD AL E++ +F    +
Sbjct: 1   MRTLRHNSPGFKSSLNSLKRSAEA-HPQVRKTVQDVLEAIRTEGDSALLEFTERFGGPRL 59

Query: 64  --TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVT 121
               L+V+ +       ++  E K+A+A A  N+  F          ++   G    +  
Sbjct: 60  TAKQLRVTGK------PKVDAETKEAVATAHANVLAFARKSLRENWTMKNAQGGLVGERF 113

Query: 122 RPVASVGLYIPGGSAPLFSTVLMLATP 148
            P   VG+Y+PGG+APL ST +M  TP
Sbjct: 114 DPFKRVGIYVPGGTAPLVSTAVMTVTP 140


>UniRef50_UPI0001696B01 histidinol dehydrogenase n=2 Tax=Listeria monocytogenes
           RepID=UPI0001696B01
          Length = 123

 Score =  123 bits (310), Expect = 1e-26,   Method: Composition-based stats.
 Identities = 39/125 (31%), Positives = 63/125 (50%), Gaps = 2/125 (1%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
             I+       E   +L +    + S  +   V  I++ VK  GD+AL ++++KFD   +
Sbjct: 1   MKILTGT--VNELLNELKIETDTNTSIQVETEVKTIIEKVKTAGDQALFDFTSKFDGVGL 58

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQPGVRCQQVTRP 123
           T L+V A +I AAS ++      A+  A  NIE+FH+ QK        + GV   Q+ RP
Sbjct: 59  TELRVPAADIQAASAKIEPAFLDALQQAKVNIESFHSKQKQHAFLDSEKDGVIRGQLIRP 118

Query: 124 VASVG 128
           + +VG
Sbjct: 119 LETVG 123


>UniRef50_D1ND55 Histidinol dehydrogenase (Fragment) n=1 Tax=Haemophilus influenzae
           HK1212 RepID=D1ND55_HAEIN
          Length = 104

 Score =  109 bits (273), Expect = 2e-22,   Method: Composition-based stats.
 Identities = 41/104 (39%), Positives = 59/104 (56%)

Query: 4   NTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTTV 63
              I WN  +  ++R+++MRP     ++I + VN I +NV   GD AL E   KFD   +
Sbjct: 1   MQTIIWNHLSETEKRKVIMRPVQQNGKNIQQAVNAIRENVAYNGDRALFELCEKFDGVKL 60

Query: 64  TALKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPV 107
             L VS +EI AAS R+S +L+ A+  A  NIE FH AQ+   +
Sbjct: 61  DKLIVSVDEIQAASSRISVKLRNAIEQAKTNIEAFHKAQQNQEI 104


>UniRef50_D1KBK9 Histidinol dehydrogenase n=1 Tax=uncultured SUP05 cluster bacterium
           RepID=D1KBK9_9GAMM
          Length = 146

 Score =  102 bits (254), Expect = 4e-20,   Method: Composition-based stats.
 Identities = 27/122 (22%), Positives = 52/122 (42%), Gaps = 4/122 (3%)

Query: 3   FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
               +       +++   L+     +S  I +TV+DI+ N++  GD+AL +Y+ KFD   
Sbjct: 1   MIARLSTQQADFQEKLSKLLAWESVSSTDIAQTVDDIIANIRQNGDQALIDYTNKFDGMD 60

Query: 63  VTA---LKVSAEEIAAASERLSDELKQAMAVAVKNIETFHTAQKLPPVDVETQP-GVRCQ 118
           V+    L V    +  A + L+++ K A+  A   +  +    K   +   T+  G    
Sbjct: 61  VSDISALTVDQSALKKAFDSLAEKEKTALQSAADRVRDYPPKNKSKTLGTYTEDNGTLLG 120

Query: 119 QV 120
             
Sbjct: 121 SK 122


>UniRef50_C7ZHH7 Putative uncharacterized protein n=1 Tax=Nectria haematococca mpVI
           77-13-4 RepID=C7ZHH7_NECH7
          Length = 337

 Score = 82.1 bits (202), Expect = 3e-14,   Method: Composition-based stats.
 Identities = 19/70 (27%), Positives = 26/70 (37%), Gaps = 1/70 (1%)

Query: 362 ASGTNHVLPTYGYTATCSSLGLADFQKRMTVQE-LSKEGFSALASTIETLAAAERLTAHK 420
             G+NHVLPT         L +  F K  T QE + +     +       + AE    H 
Sbjct: 54  CIGSNHVLPTRKVGNYTGGLWVGKFLKTQTYQEIVDERASGEMGRLCGRCSRAENFEVHA 113

Query: 421 NAVTLRVNAL 430
            +  LRV   
Sbjct: 114 RSGDLRVKKY 123


>UniRef50_UPI00016988E7 histidinol dehydrogenase n=1 Tax=Endoriftia persephone
          'Hot96_1+Hot96_2' RepID=UPI00016988E7
          Length = 102

 Score = 73.2 bits (179), Expect = 2e-11,   Method: Composition-based stats.
 Identities = 18/82 (21%), Positives = 39/82 (47%), Gaps = 3/82 (3%)

Query: 1  MSFNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDK 60
          MS    +  +    + +   L+     +  ++  TVN+I+  +++RGD AL E++++FD 
Sbjct: 1  MSEIRQLSSSDADFQSRLDALLAWESVSDRAVNDTVNNIIAEIRSRGDAALVEFTSRFDG 60

Query: 61 TTVTA---LKVSAEEIAAASER 79
              +   L++    +  A E 
Sbjct: 61 WQAASAADLELPLSRLEQAWEH 82


>UniRef50_D2MHU6 Putative uncharacterized protein (Fragment) n=1 Tax=Candidatus
          Poribacteria sp. WGA-A3 RepID=D2MHU6_9BACT
          Length = 74

 Score = 65.1 bits (158), Expect = 4e-09,   Method: Composition-based stats.
 Identities = 19/72 (26%), Positives = 29/72 (40%), Gaps = 2/72 (2%)

Query: 3  FNTIIDWNSCTAEQQRQLLMRPAISASESITRTVNDILDNVKARGDEALREYSAKFDKTT 62
             +I     T  +    +   A      I   V  IL NV+  GD A+  Y  KFD  T
Sbjct: 1  MMNVISSKDKTYPEALAEVCNRAACQHAKIEGRVKRILKNVERNGDAAVSRYVKKFDGLT 60

Query: 63 VTA--LKVSAEE 72
          ++    +VS++ 
Sbjct: 61 LSPKKFRVSSKR 72


>UniRef50_C0S8B7 Histidinol dehydrogenase n=1 Tax=Paracoccidioides brasiliensis Pb03
           RepID=C0S8B7_PARBP
          Length = 227

 Score = 63.2 bits (153), Expect = 2e-08,   Method: Composition-based stats.
 Identities = 27/103 (26%), Positives = 41/103 (39%), Gaps = 32/103 (31%)

Query: 239 VLVIADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELPRAETA 298
           VL++A + A    +A+DLLSQAEH PDS  ++ T A D  +            L      
Sbjct: 128 VLIVAGNKADRFTIATDLLSQAEHSPDSPAVIFTTAEDAGK------------LETRY-- 173

Query: 299 RQALNASRLIVTKDLAQCVEISNQYGPEHLIIQTRNARELVDS 341
                               ++++Y  EH+ I T+  RE    
Sbjct: 174 ------------------FRLADEYAFEHVQILTQPPREAGAR 198



 Score = 44.3 bits (104), Expect = 0.008,   Method: Composition-based stats.
 Identities = 13/43 (30%), Positives = 25/43 (58%), Gaps = 1/43 (2%)

Query: 37 NDILDNVKARGDEALREYSAKFDKTTVTALKVSAEEIAAASER 79
            +++++++ GD A+R +S KFD    T  K S ++I A   +
Sbjct: 34 KRVIEDIRSNGDSAVR-HSTKFDHWEPTPFKPSDDDIQAVIAK 75


>UniRef50_C8S5L7 Putative uncharacterized protein n=1 Tax=Rhodobacter sp. SW2
           RepID=C8S5L7_9RHOB
          Length = 151

 Score = 55.1 bits (132), Expect = 5e-06,   Method: Composition-based stats.
 Identities = 22/73 (30%), Positives = 36/73 (49%), Gaps = 3/73 (4%)

Query: 252 VASDLLSQAEHGPDSQVILLTPAADMARRVAEAVERQLAELP---RAETARQALNASRLI 308
             +DL+ QAEHG +S V L+T    +A RV   V   +  LP   RA  A    + + +I
Sbjct: 16  ATADLVGQAEHGYNSPVWLVTSDRGLAARVTALVPELIVALPEPNRASAAAAWADLAEVI 75

Query: 309 VTKDLAQCVEISN 321
           + +D  +   + +
Sbjct: 76  LCEDAEEMARVFD 88


>UniRef50_B8FPV4 Putative cell wall binding repeat 2-containing protein n=2
           Tax=Desulfitobacterium hafniense RepID=B8FPV4_DESHD
          Length = 530

 Score = 41.6 bits (97), Expect = 0.058,   Method: Composition-based stats.
 Identities = 34/164 (20%), Positives = 63/164 (38%), Gaps = 38/164 (23%)

Query: 140 STVLML----ATPASIAGCK-------KVVLCSPPPIADEILYAAQLCGVQDVFNVGGAQ 188
           STV++        A +A           +++ S   +++E+L+     G + V+ +GG  
Sbjct: 248 STVILTRDDVVADAMVA-VPLSKKYDAPILMTSSQRLSNEVLHEILNLGAETVYMIGGTG 306

Query: 189 AIAA------LAFGTESVPKVDKIFGPGNAFVTEAKRQVSQRLDGAAIDMPAGPSEVLVI 242
           AI+A        FG  +     ++ G  N + T A+           I    GPS+ + +
Sbjct: 307 AISAEIESELQTFGITT----QRLAGA-NRYDTAAQ-----------IAELVGPSDRVYL 350

Query: 243 ADSGATPDFVASDLLSQAEHGPDSQVILLTPAADMARRVAEAVE 286
           A     PD +A    + A+       ILLT    +       ++
Sbjct: 351 AYGYGEPDAIAVSSFAAAQ----GASILLTDTHSLPEETQNRLK 390


  Database: uniref50.fasta
    Posted date:  Mar 8, 2010 10:38 AM
  Number of letters in database: 1,040,396,356
  Number of sequences in database:  3,077,464
  
Lambda     K      H
   0.312    0.168    0.532 

Lambda     K      H
   0.267   0.0514    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 2,520,569,421
Number of Sequences: 3077464
Number of extensions: 157755600
Number of successful extensions: 377316
Number of sequences better than 1.0e-01: 155
Number of HSP's better than  0.1 without gapping: 302
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 375671
Number of HSP's gapped (non-prelim): 329
length of query: 434
length of database: 1,040,396,356
effective HSP length: 132
effective length of query: 302
effective length of database: 634,171,108
effective search space: 191519674616
effective search space used: 191519674616
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.0 bits)
S2: 95 (40.9 bits)
