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    Reference sequence (query): batch____
    Identities normalised by aligned length.
    Colored by: property

    HSP processing: ranked
    Search cycle: 3

                                                                                                          1 [        .         .         .         .         :         .         .         .         .         1         .         .         .         .         :         .         .         .         .         2         .         .         .         .         :         .         .         .         .         3         .         .         .         .         :         .         .         .         .         4         .         .         .         .         :         .         .       ] 478
        batch____                                              bits   E-value  N 100.0%   1:478             MSNNIRIEEDLLGTREVPADAYYGVHTLRAIENFYISNNKISDIPEFVRGMVMVKKAAAMANKELQTIPKSVANAIIAACDEVLNNGKCMDQFPVDVYQGGAGTSVNMNTNEVLANIGLELMGHQKGEYQYLNPNDHVNKCQSTNDAYPTGFRIAVYSSLIKLVDAINQLREGFERKAVEFQDILKMGRTQLQDAVPMTLGQEFRAFSILLKEEVKNIQRTAELLLEVNLGATAIGTGLNTPKEYSPLAVKKLAEVTGFPCVPAEDLIEATSDCGAYVMVHGALKRLAVKMSKICNDLRLLSSGPRAGLNEINLPELQAGSSIMPAKVNPVVPEVVNQVCFKVIGNDTTVTMAAEAGQLQLNVMEPVIGQAMFESVHILTNACYNLLEKCINGITANKEVCEGYVYNSIGIVTYLNPFIGHHNGDIVGKICAETGKSVREVVLERGLLTEAELDDIFSVQNLMHPAYKAKRYTDESEQ
      1 UniRef50_A6LYC0        Fumarate lyase n=4 Tax=Clos...   457    1e-127  1  47.4%   4:478  13:484     ---NFRKENDSIGSKDIPEDVYYGVQSLRAAENFRITG--LFMHPEIINSLAYIKKAAAITNCEVGVLDKKIADAIVKACDEIL-RGNLHEYFIVDPIQGGAGTSLNMNANEVIANRAIEILGGKKGEYSIVHPNDHVNCGQSTNDVIPTAGKITALKLLEHAQSELYRLHDAFSQKAIEFDHIIKMGRTQMQDAVPIRLGQEFKAYSVAIMRDVNRMEKAMDEMRVLNMGGTAIGTGVNADVKYLKRVVPNLSEITGMDLIQAFDLIDSTQNLDSFVAVSGAVKACAVTLSKIANDLRLMSSGPRTGFGEINLPAKQNGSSIMPGKVNPVIPEVVNQVAFNIIGNDTTITMAAEGGQLELNAFEPIIFYCLFQSIDTLTYAVQTFIDNCVKGITANEERCRDLVENSVGIITAICPHVGYSTAASLAKEAIKTGTSIRTLILEAGLLSEDELNEILDPFNMTEPGISGKKSISNELK
      2 UniRef50_B2A2B6        Fumarase n=35 Tax=cellular ...   455    1e-126  1  48.3%   1:472   6:474     VKEITRVECDSLGSKEIPKDAYYGIQSKRAQENFPLSGYRV--HPELIKAMGKVKYASVVANMKTGKMPNKSGEAIKQACEEMSS-GKFFDAIVVEAIQGGAGTSINMNVNEILANRAIEILGHEKGDYDVVSPNTHVNMSQSTNDVVPTSFKLAVITMREDLISKLENLYQTLSKKEQEFDKVIKTGRTHLQDAVPIRLGQEFGAYARFVKRDIERISNSIEALKTVNLGATAVGTGLNADSKYINTAIEELREITGIDLEISDHLVDATQNTDAYVHVSGALKTAALNMSKMANDLRLMSSGPRCGFKEIKLPAVQPGSSIMPGKVNPVIPEVINQICFQVAGNDHTISMASEAGQLELNVMGPVLFRNMFESMEIIANGAHILSEKCIKGIEPNHDRCNELVENSIGIITALNPHIGYETASEIAKEVLETGRSVRDVILEREILTEEEIEDILDPKEMTEPGIAGKKK------
      3 UniRef50_P07954        Fumarate hydratase, mitocho...   453    1e-126  1  38.1%   2:465  47:509     -QNSFRIEYDTFGELKVPNDKYYGAQTVRSTMNFKIGGVTERMPTPVIKAFGILKRAAAEVNQDYG-LDPKIANAIMKAADEV-AEGKLNDHFPLVVWQTGSGTQTNMNVNEVISNRAIEMLGGELGSKIPVHPNDHVNKSQSSNDTFPTAMHIAaiEVHEVLLPGLQKLHDALDAKSKEFAQIIKIGRTHTQDAVPLTLGQEFSGYVQQVKYAMTRIKAAMPRIYELAAGGTAVGTGLNTRIGFAEKVAAKVAALTGLPFVTAPNKFEALAAHDALVELSGAMNTTACSLMKIANDIRFLGSGPRSGLGELILPENEPGSSIMPGKVNPTQCEAMTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMMIKNVLHSARLLGDASVSFTENCVVGIQANTERINKLMNESLMLVTALNPHIGYDKAAKIAKTAHKNGSTLKETAIELGYLTAEQFDEWVKPKDMLGP-------------
      4 UniRef50_Q9ZLI5        Aspartate ammonia-lyase n=3...   451    1e-125  1  56.2%   5:465   1:460     ----MRIEHDFIGQMEISDEVYYGIQTLRASENFFITNDKLCSYPVFIKSFAQVKKAAALANAQLGLIDEKLKIAICHACD-LLVDGKYHDQFIVDMIQGGAGTSTNMNMNEVIANLALEYMGHQKGEYQFCHPNDHVNRSQSTNDAYPSALKIAIYERLSNLVAPMKALRDAFAQKAKEFAHVIKMGRTQLQDAVPMTLGQEFETYALMVDRDIEQVLDARNWVRELNLGGTVIGTGINSHPDYRSLIEKKIQEVTGRPFVMANNLIEATQSTGAYVQVSGVLKRIAVKLSKVCNDLRLLSSGPRAGLNEINLPKMQPGSSIMPGKVNPVIPEVVNQVCFAVIGNDLSVALAAEGGQLQLNVFEPVIAYKLFHSFVILGRAIETLTTKCVEGITANEKICHDYVFNSIGIVTALNPHIGYEKSAMIAKEALKSDRSIYDIALEKKILTKEQLDDIFKPENMLSP-------------
      5 UniRef50_B8DKU3        Fumarate lyase n=90 Tax=Bac...   445    1e-123  1  53.2%   4:465   6:466     ---EYRIERDSLGERKVPAHAYYGVQTLRALENFDVTGLTIGRHPRFVQALASVKKAAALANMELGLLDGDVGQAIVQACREVR-EGRFDEQFVVDIIQGGAGTSVNMNANEVIANRALELMGRTRGEYGVVSPLNHVNLSQSTNDVYPTAFRIALVWYARDLGVSLRELRDAFHAKGEAFADVIKMARTQLQDAVPITLGAEFAAYGVTVGEDIDRLAEVARLLCEVNIGATAVGTGINTVPGYAPLVCDRLADITGLPLSLSPNLVEATSDAGAYVTLSGLLKRVAVKLSKICNDLRLLSSGPFTGLGEISLPAVQPGSSIMPGKVNPVIPELVNQVCQQVIGNDLTVTLAAEAGQLELNVFGPIMACNLFQSLEILTRAARILRVRCVEGITANRERCLELLHGSLGMVTALAPVIGYEAAATVVKDARATGRTPRDLLVERGLMRSEDYDDLMDPAKMLGP-------------
      6 UniRef50_P08417        Fumarate hydratase, mitocho...   444    1e-123  1  37.8%   1:465  24:487     MNSSFRTETDAFGEIHVPADKYWGAQTQRSFQNFKIGGARERMPLPLVHAFGVLKKSAAIVNESLGGLDPKISKAIQQAADEV-ASGKLDDHFPLVVFQTGSGTQSNMNANEVISNRAIEILGGKIGSKQ-VHPNNHCNQSQSSNDTFPTVMHIAASLQIqeLIPELTNLKNALEAKSKEFDHIVKIGRTHLQDATPLTLGQEFSGYVQQVENGIQRVAHSLKTLSFLAQGGTAVGTGLNTKPGFDVKIAEQISKETGLKFQTAPNKFEALAAHDAIVECSGALNTLACSLFKIAQDIRYLGSGPRCGYHELMLPENEPGSSIMPGKVNPTQNEALTQVCVQVMGNNAAITFAGSQGQFELNVFKPVMIANLLNSIRLITDAAYSFRVHCVEGIKANEPRIHELLTKSLMLVTALNPKIGYDAASKVAKNAHKKGITLKESALELGVLTEKEFDEWVVPEHMLGP-------------
      7 UniRef50_C9R7S2        Fumarate lyase n=1 Tax=Ammo...   438    1e-121  1  43.6%   3:477   2:473     --TEYRWERDSLGEKAVPKEAYYGIHALRAKENFPVSGQK--PHRELLWALGVVKQAAASANTAVGLLPPEKGEAIERAAAEF-ASGRFDDQILVDVYAGGAGTPLNMNVNEVIANRALEILGFEKGSYHIIHPLEHVNLSQSTNDVFPTAVKVAAIKLVRRLSQAMARLQGALQRKEKEFASVLKIGRTEMQDAVPITLGQEFGAWAEAVARDWWRLYKVEERLRQVNLGGTAVGTGLNASRRYIQLVAEKLRELTGFGLARAENLVEATQNTDIFAEVSGLVKTAAVNLAKIASDLRFLSSGPRAGIGEIRLPAVQVGSSIMPGKVNPVIPEMVTQVAIQVMANDVAISQACAWGNLELNPFLPLIAHNLLTSMEMLANAALILAERCVEGIEADWERCEELLHRSCGLITAFVPYIGYERAAEIVKEALGKEKRVEEVLLEKGLFTPEEIAAITSPQEVTTPGIAGIRYFVQRK-
      8 UniRef50_B0S039        Aspartate ammonia-lyase n=1...   435    1e-120  1  48.2%   4:478  19:490     ---DYRLESDSVGEKQVPKDAYYGVQSLRGMENFPITGRTL--HEELIYGLTIVKKACAIANHRAGIMREDVKNAIVYACDQILK-GEYHDQFLTDPIQGGAGTTANMNANEVIANIANEKLGGGLGTYEYVHPNDHVNMSQSTNDVFPTAGKIATLRLLIKALNELKQLEISLLNKSVEFDDVLKMGRTQLQDAVPIRLGQEFHAYYSVIKRDIKRIRRSSDQIESINMGATAIGTGVNVDKVYFTNIVPILAELTGFDLHQAEDLIDGTNNLDGLVEISSAVKSTAVSLSKMASDLRLMSSGPKTMVGDIELPPRQNGSSIMPGKVNPVIPEVVNQVVFRIIGNDNTVTMCAEHGQLELNAFEPVLFDSLFESISILTNAVRTFRENCIIGIKPNRQKLSNDVEKSVGIVTALVPHIGYKKSAEIAKRALSTGITVRNIVLDEKILTEDELKEILDPIAMTMPGIAAEYLIKQKQQ
      9 UniRef50_D2LRV9        Aspartate ammonia-lyase n=2...   435    1e-120  1  49.4%   4:473   7:473     ---STRTERDLMGEKEIPADAYYGIQTVRAKENFPITG--YPPHKELIRAFGYVKKAAAKANADVGVLNKNIAEAIIKASDEVI-EGKLNDHFIVDSIQGGAGTSFNMNANEVIANRAIEILGGKKGDYIKVSPNTHVNMAQSTNDTFPTAIHIACLHLSSGLIRSLNDLIESMRKKEREFDDVIKMGRTHLQDAVPIRLGQEFGSYRRLLSRDLGRIKRSVDLLYEVNMGATAVGTGLNAMPEYIEKVTEHLAAMTSMPLHRAEDLVDATQNTDAYTQLSSAMKILAINLSKIANDLRLMSSGPRTGINEINLPPRQAGSSIMPGKVNPVMCEVINQISFQVIGNDHTISLASEAGQLELNVMEPVLVFNLLQSFTILQNGMKVFRDFAIEGMTANIEHCKELVERSVGIITAINPHVGYETAARVAKEAITTNRPVREICHERGLLSEEELERILDPNEMTNPGIAARELI-----
     10 UniRef50_D2EG45        Fumarate lyase n=2 Tax=Cand...   434    1e-120  1  45.6%   3:465   2:461     --ENYRIEKDYLGEVKVPYDAYWGVQTQRAMDNFPISG--LRPIKNYTYAIIRIKKAAALANSEAGLLDKKKAKAIIEACDEILK-GKYDDQFLVDVYQAGEGTSNNMNANEVIANIAIEKLKGKKGDYSIIHPNDDVNMGQSSNDVIPTAIKLAAIELSNKLIDSLKELQTAFYKKAKEFDKIIKSGRTHLMDAAPIRLGQEFGAWADLIKDSILRIQAAKNELKKINLGGTAVGTGINADSRYTKNAIAYLSKFINERLVQAKDLPEVTESPSDLFNLSSALSVLSTDLIKIANDLRLMNSGPITGLAEISLPAVQPGSSIMPGKVNPSVAEMVDMVSFRVLGDSHTIELATQAGQFELNVMEPIINYCLLHDLIILGNACKVFSEKAINGIKVNKEHIAEMVEKTPGIGLALNPYIGYEKAAEVVKEAIKTNKSIPQLVKEKKLLSEKDFKEVFDPFNLTWP-------------
     11 UniRef50_Q92PB6        Fumarate hydratase class II...   433    1e-120  1  37.9%   3:466   2:463     --TSTRTETDTFGPIEVASDRYWGAQAQRSLGNFKIGWEK--QPLAIVRALGIVKQAAARANMALGRLDPAIGDAIVKAAQEVI-DGKLDEHFPLVVWQTGSGTQSNMNANEVVSNRAIELLGGVMGSKKPVHPNDHVNMSQSSNDTYPTAMHIACAEriHDLLPALKHLHKALEEKVKAFDHIIKIGRTHTQDATPLTLGQEFSGYAAQVASSIKRIEMTLPGLCELAQGGTAVGTGLNAPVGFAEKVAEEIAAITGIGFTSAPNKFEALAAHDSMVFSHGAINATAAALFKIANDIRFLGSGPRSGLGELSLPENEPGSSIMPGKVNPTQCEALTQVCVQVFGNHAALTFAGSQGHFELNVYNPLMAYNFLQSVQLLADAAISFTDNCVVGIEAREDNIKAALDRSLMLVTALAPKIGYDNAAKIAKTAHKNGTTLREEAVGGGYVTDEEFDAVVRPETMIGPA------------
     12 UniRef50_B0WME6        Aspartate ammonia lyase n=1...   429    1e-118  1  36.6%   4:465  42:480     ---GFRTESDTFGELKVPNDKYYGAQTVRSTMNFPIGGPTERMPQPVITAMGILKKAAALVNKEYG-LDPKVADAIALAADDVISGKLYDDHFPLVIWQTGSGTQSNMNVNEVISNRAIELMGGTLGSKTPVHPNDHVNKSQSSNDTFPTAIHivARELTGNLKPAIQTLHDALKAKSDEFKDIIKIGRTHTQDAVPLTLGQEFSGYVQQMEFALQRIEACLPRVYMLALGGTAVGTGLNTRIGFAEKCAAKISELTGLPFVTAPNKFEALAARDAMVEVSGCLNTIAVSCMKIANDIRFLGSGPRCGLGELSLPENEPGSSIMPGKVNPTQCEAMTMVCAQVMGNNVAVTVGGSN-----------------------ADSARTFSKNCVVGIQANRANIDKIMNESLMLVTALNPHIGYDKAAKIAKTAHKEGTTLKQAALKLGYLNEQQFNEWVRPENMLGP-------------
     13 UniRef50_C9KQJ0        Aspartate ammonia-lyase n=1...   427    1e-118  1  45.0%   5:468   1:461     ----MRKEHDFIGELEVPDEVYYGVQTMRAIDNFHITGQTI--DPDFVQSIARVKKAAAMANMATGRLDKKIGEALIEAADEII-DGKLLDQFPVDPIQGGAGTSINMNMNEVLCNRALEIIGQPKGRYDIISPNNHANMAQSTNDSFPTSIKVCLSHKAKKLTAALDRLATELEKKSEEYKDVLKMGRTHLQDAVPITLGQEMGMYASAVRRGIRRIDHAIDEIHVMNMGGTAVGTGLNAEPAYIKKVAETLSEVTGEKYVTADNMIDATNNTDGFSDVSSAMKTTALVLIKMANDFRLMASGPRCGLNELKLPKRQPGSSIMPGKVNPVIAEVLDQACYQVIGNDLAVSMGVENGQFELNVMEPVMAFNMFNSMKYMTNAVNTFVDKLLIGLEPNREQCQKWLDNSVGVVTALLPHIGYENSAMLAKEAYNTGKPIRQVIMEKGLLSREKMEHILSPRQMTTPGIA----------
     14 UniRef50_C3PG94        Aspartate ammonia-lyase n=7...   427    1e-118  1  65.3%   6:475  41:510     -----RTETDLLGSVEVPSDAYYGVHTLRAIENFQISYVTINTIPDFIRGMVQVKKATAMANRRLHVLPKKKAEAIIWACDQILEEGRCMDQFPLDVFQGGAGTSLNMNTNEVVANLALEYLGEEKGSYDVINPNDDVNMSQSTNDAYPTGFRLGIYYAMEDLIERIDTLQAAFHAKGNEFVDILKMGRTQLQDAVPMTLGDEFKAFAHNLAEEQAILRDAQKRLLEINLGATAIGTGVNTPAGYRHQVTAALSEVTGLEIKTARDLIEATSDCGAYVLLHSTIKRAAMKLAKICNDLRLLSSGPRAGLAEINLPPRQAGSSIMPGKVNPVIPEVVNQVCFKIFGNDHVVTMAAEAGQLQLNVMEPVIGEALFQSIRIMGNAVDTLREKCVVGITANADVCRAYVENSIGIVTYLNPFIGHHNGDMIAKESLKTGKGVKELVLEKGLLDEETLNKVLSVENLMHPEFRGQLYIDE---
     15 UniRef50_C8P032        Aspartate ammonia-lyase n=1...   424    1e-117  1  44.8%   2:465   7:467     -NQNVRIEYDSLGSVKVPKDALYGAQTVRALQNFQITGRHVNDMMYL--ALAQVKKACALANKSVGELDGPRCDAIVFACDEIIS-GKYKEAFITDAIQGGAGTSMNMNVNEIIANRAAQILNRPIGVYDYIHPNDHVNRAQSTNDIIPTAGKLTVLNLGLLLVEEMIFLADTFHAKALEFSNIIKVGRTHLQDAVLISMGQVFHSYESVVRRDIQRLKQSLSEMQVINLGATAVGTGINSVEGYREHAVTHLSRITGKSFVSAEDLVDATKHVDGFANVHGSLKTFAVGLSRICNDIRMMASGPKVGFNEIFLPEKQPGSSIMPGKVNPVIPEVVNQVCFQVIGNDATVTLAAEAGQMELNVFEPVLFDNLFESLEILRHACATLRIHAIQDIKVNEHRIQDYVEHSLAMATALVKYLGYEKVSEITKQALKENKSLKTLVLEQGLMSEAEVDEALKPESMIHP-------------
     16 UniRef50_C5B2U6        Aspartate ammonia-lyase (As...   423    1e-117  1  53.7%   2:465 100:563     -GAKTRSEHDLLGDGEVPADALWGIHTKRAVANFPITGVSVGHYPELVRALALVKQAAARSNHRLGYLPKGKAKIIEEACTLVATDPTYAESFVVDAIQGGAGTSTNMNANEVIANVGLRLMGKAPGDYAALHPNDDVNMAQSTNDAYPTALRLAVIFATQPLVKALDDLAYAFKSKAVEFADVLKMGRTQLQDAVPMTLGQEFDGFHATIKEDVARLTEIVGLFREVNLGATAIGTGINADPRYAALAVEELSRLSGQPMVLASNLIEATSDLGAFVLFSGVLKRVAVKLSKICNDLRLLSSGPRTGFGEIRLPAVQAGSSIMPGKVNPVIPEVVNQVAYMVIGHDLTVTLCAEGGQLQLNAFEPTIGYCVLSSLRMLTAAIDTLTKRCIDGIEADRERCRSLVQGSIGLVTALAPTLGYEASSRIARRALKENRAVADLVLEEGLLTEAQLNGLLELEAMTHP-------------
     17 UniRef50_Q59200        Aspartate ammonia-lyase n=1...   422    1e-116  1  64.5%   1:465  52:516     VQKKFRIESDLLGELQIPSHAYYGVHTLRAVDNFQISRTTINHVPDFIRGMVQVKKAAALANRRLHTLPAQKAEAIVWACDQILIEERCMDQFPIDVFQGGAGTSLNMNTNEVVANLALEFLGHEKGEYHILHPMDDVNMSQSTNDSYPTGFRLGIYAGLQTLIAEIDELQVAFRHKGNEFVDIIKMGRTQLQDAVPMSLGEEFRAFAHNLAEEQTVLREAANRLLEVNLGATAIGTGVNTPAGYRHQVVAALSEVTGLELKSARDLIEATSDTGAYVHAHSAIKRAAMKLSKICNDLRLLSSGPRAGLNEINLPPRQAGSSIMPAKVNPVIPEVVNQVCFKVFGNDLTVTMAAEAGQLQLNVMEPVIGESLFQSLRILGNAAKTLREKCVVGITANADVCRAYVDNSIGIITYLNPFLGHDIGDQIGKEAAETGRPVRELILEKKLMDEKTLEAVLSKENLMHP-------------
     18 UniRef50_B1I0U7        Fumarate lyase n=21 Tax=Bac...   418    1e-115  1  45.9%   4:478  10:481     ---DTRTEKDPLGEVAVPREAYYGVHTWRARENFAVSGLAV--HPELIRALALVKKAAAMANVEAGLLDDRRGAAISRAAEEL-AEGRWRDQIIVDALQGGAGTSTNMNVNEVIANRAIELLGGEKGDYGIVHPLDHVNLGQSTNDVYPTALRIAAIGLGRGLAQAMAVLQGALQAKEKEFGAILKIGRTQLQEAVPVTLGQEFGAWAEAVARDWWRLYKAEERLRQVNLGGTAVGTGLNADRRYAYRVVEILRELTGFGLARAENTFEATQNADIFAEVSGFLKAAAVNLAKISADLRLLASGPRAGLGEIKLPPVQAGSSIMPGKYNPVVPEMVTQTAFQVMANDLAVSLAAASGQLELNAFLPLIAHNLLQSFTILTGAAGTLAEKCIRGITADPERCRRLLDTSQGVITAFVPYLGYEQAAAVVERAIRTQRPLTEILVEEGLFTLEEVEAIMRPEELTTPGVAGARYFQRQKR
     19 UniRef50_Q8TS07        Fumarate hydratase class II...   415    1e-114  1  36.9%   2:464  13:473     -ATGKRKESDSLGEVEVPADHYWGAQTQRSLIHFSIGDDY--MPKEVYHAYGYVKKAAALVNEAAGIIPPWKAELIARVADEVIA-GKLDSEFPLYVWQTGSGTQSNMNVNEVISNRAIQLVGGSLGSKHPVHPNDDVNMSQSSNDTFPTAMHIavLEFSNRLIPAVTVLEESIWAKAREWVDIVKIGRTHLQDATPLTVGQEWSGYATQLDDALAFVKHSLRGLYRLAIGGTAVGTGINTPPDFGEKVADEIARLTGHPFVTAPNKFAAQGSLDAMVTSSAALRTLAVALMKIANDLQWLGSGPRSGLHELILPSDEPGSSIMPGKVNPTQEEAMLMVCIQVIGEDNAVAFAGSQGNFELNAMCPIIINNVLHSARTLGDACVKFREYGINGIMLDRSRIDKFVGTSLMLVTALSPVIGYDKASAIVQRALDENTTLREAAVKGGFISAEDFDRIVDPKKMVG--------------
     20 UniRef50_P07346        Aspartate ammonia-lyase n=1...   415    1e-114  1  57.1%   2:465   8:471     -AASFRTEKDLLGVLEVPAQAYYGIQTLRAVNNFRLSGVPISHYPKLVVGLAMVKQAAADANRELGQLSERKHAAISEACARLI-RGDFHEEFVVDMIQGGAGTSTNMNANEVIANIALEAMGHQKGEYQYLHPNNDVNMAQSTNDAYPTAIRLGLLLGHDALLASLDSLIQAFAAKGAEFSHVLKMGRTQLQDAVPMTLGQEFRAFATTLGEDLARLKTLAPELleVNLGGTAIGTGINADPRYQALAVQRLATISGQPLVPAADLIEATSDMGAFVLFSGMLKRTAVKLSKICNDLRLLSSGPRTGINEINLPARQPGSSIMPGKVNPVIPEAVNQVAFQVIGNDLALTMAAEGGQLQLNVMEPLIAFKIFDSIRLLQRAMDMLREHCIVGITANEARCRELVEHSIGLVTALNPYIGYENATRIARIALESGRGVLELVREEGLLDDAMLDDILRPENMIAP-------------
     21 UniRef50_Q65DB2        L-aspartase n=5 Tax=Bacteri...   414    1e-114  1  48.6%   5:471   7:470     ----YRTEKDFLGEKKIPADVYYGIQTLRAAENFPITGYKI--HEEMIKALAVVKKAAALANMETKRLYKGLGDAIVQAADEIL-EGKLHDQFIVDPIQGGAGTSMNMNANEVIGNRALELLGHNKGEYIHLSPNTHVNMSQSTNDVFPTAIHISTLKLLEKLLDTMEYMLDAFKKKARDFDHVIKMGRTHLQDAVPIRLGQEFEAYSRVIERDIKRIKQSRQHLYEVNMGATAVGTGLNADPRYIENVVKHLAEISGLPLVGADHLVDATQNTDAYTEVSAALKVCMMNMSKIANDLRLMASGPRAGLAEISLPARQPGSSIMPGKVNPVMAELINQIAFQVIGNDHTICLASEAGQLELNVMEPVLVFNLLQSISIMNNGFRSFTDHCVAGIEANEKRLKAYVEKSAGVITAVNPHLGYEAAARIAREAILTGQSVRDLCLQNDVLTEEELDLILNPYEMTKPGIAGAE-------
     22 UniRef50_B1MWT6        Aspartate ammonia-lyase n=6...   411    1e-113  1  46.2%   5:463   1:457     ----MRIESDSLGQLNIPQSTYYGIHTQRALNNFPISKAS--THPELIRAFIEIKQAAAQTNATSGNLNRSVAKHIVSATKILLNQPIDTTMFPISDIQGGAGTSTNMNVNEVIANLALEKVGRQRGDYQFIHPNDHVNMGQSTNDTYPSAGKIALIRLLAPLLNELTQLIDALGNKADEFSTTYKMGRTQLQDAVPMTLGNSFHAWLKPLLRDNLRIQSARDSLYYLNMGGSAIGSGINVSYHYQVHIVPNLAGITKLPLKQAHDLFDATQNLDSFVALSGTLKTLAVNLSKIANDLRLLSSGPRSGLLEINLPAKQAGSSIMPGKVNPVIPEVVNQVAFEYFGFDATVTAAAEAGQLELNAFEPIVFKSLFTGIEHLTAAMATLRINAIDGITSNKNRLAQDIDLSVSFATAMAPIVGYQLAAKMAKESLRTGKSLRQIAEKKNCFTPEELAHIFKVEDIV---------------
     23 UniRef50_B4SPD1        Fumarate lyase n=7 Tax=Bact...   411    1e-113  1  39.2%   2:463   6:462     -SKGFRIEHDSMGELQVPADALWGAQTQRAVQNFPVSGQR--MPRGFIRALGLVKGAAAGVNAELGHLPKNVAKAIQTAAAEVAT-GEWDAHFPIDVYQTGSGTSSNMNANEVIATLANRA---GKAGKTSVHPNDHVNQGQSSNDVIPTALRvaVLATHEQLLPALVHLRKTLDKKGRSLRKVVKTGRTHLMDAMPLTFEQEFGAWSAQLASAQERIEDSLKRVRRLPLGGTAIGTGINADPRFGTQVAKALKQQTGFKFDSAENKFEGLAAQDDAVELSGQLNALAVALIKIANDLRWMNAGPLAGLGEIELPALQPGSSIMPGKVNPVIPEATVMACAQVIGHHTAITVAGQTGNFQLNVTLPLIAVNLLDGIGLLANVSTLLADSAIAGLKVREDRVAEALARNPILVTALNPIIGYEKAAAIAKRAYKEQRPVLDVALEDSGLAEAELRRLLDPTALT---------------
     24 UniRef50_C1F6I6        Aspartate ammonia-lyase n=1...   411    1e-113  1  43.7%   3:478   2:473     --TELRKEKDSLGFVEVPANAYYGAQTARAVENYPISGMR--AHPQLIRAFGMVKQAAAEANQELGLVEAPRAEAIRKAAQEVM-DGKWNAEFVVDVFQAGAGVSFHMNTNEVIANRANEILGGKLGEYAQVHPNDHVNYGQSTNDVFPTGMRVATLLALETLYPVLDKLAATFEAKAKEFHDVMKSGRTHMQDAVPIRLGQEFAAYGLAIEKGKKFLTLAADSLRELGLGGSAVGTGINTHPDYRAKAVAALSRISGQKLTPAADMRWAMQSNACMADVSAALRGIALEVIRISNDLRLISSGPNTGYAEIYLPSLQPGSSIMPGKINPVMPELAAMVSFQVVGNDTAVAMAVQAGQLELNVMMPTMAYSVLQSITILANMLRQFNDRCVAGITANAERCAQYAQSTVSLATALNPYIGYAKAAEIVKESVATGQSIISIARSKGLLSEQEISEILDPVRMTEPQYPL-DAAKERDK
     25 UniRef50_Q3A7R0        Fumarase n=14 Tax=cellular ...   410    1e-113  1  41.1%   3:472   2:468     --TATRIEKDSMGTMEVPASALYGAQTARALANFPISGQRFSRP--FIHALGLIKRYAAQANLELGMLDEQRATAIMQAADEVI-NGELDEHFVLDIFQTGSGTSTNMNANEVIANRAAQILGQAAGSR-AVHPNDHVNLGQSSNDVIPTAMHIAAALEIrsLVKALFDMQEALGEKALAFNDIIKIGRTHLQDATPVRLGQVFSGYARQLALAIRGIERAQDDLLELALGGTAVGTGLNAHPQFATRAIAAISDQTGLEFREASNHFEAQAAKDAVVAASGALKRGACALFKIANDIRLLGSGPRCGIGELQLPPVQPGSSIMPGKVNPVMAESLMQVCAQVIGNDAAIALGGLSGNFELNVMMPVMAHNLLQSITLLTNASTQFTRRCLQGLEADRARCESLVEQSLAMCTALAPVIGYDQAADIAKQAFASGRTVREVALEQQVLPEEKLAQVLDPRPMTEPGIPGKTR------
     26 UniRef50_D2UDT9        Probable fumarate hydratase...   410    1e-113  1  38.4%   1:464   1:462     MSEKYRVEHDSMGELQVPIDALWGAQTQRAVQNFPISGR--PMPRGFIRALGLIKAAAAGVNAELELLPKAVAKAIQAAALEV-ADGRHDAQFPVDIYQTGSGTSSNMNANEVIATLASRAAKSGAKATSAVHPNDHVNLGQSSNDVVPTAIRvaLLAAQEQLLPALKHLRKVIDKRARQLERVVKTGRTHLMDAMPLTFGQEFGAWSAQLASAQERVSDSLKRLRRLPLGGTAIGTGINADPRFGGKVAKALSTLTDCKFESADNKFEGLAAQDDAVELSGQLNALAVALIKIANDLRWMNAGPLAGLGEIELPALQPGSSIMPGKVNPVIPEATVMVCAQVIGHHTAITVAGQTGNFQLNVTLPLIAANLLESIQLLSNVSRRLADSAIAGLRVREERVREALERNPILVTALNPIIGYEKAAAIAKRAYKENRPVLDVAAEDSGLSKDALRRLLDPAALTE--------------
     27 UniRef50_C5C2S8        Fumarate lyase n=10 Tax=Bac...   409    1e-112  1  53.6%   2:464  17:478     -SGLTRTEHDLLGDRQVPLEAYYGVHSVRAVENFPISGVRLRRLTELINAIAAVKQASALTNAELGLLPQEKADAIVEACQEIRA-GALHDHFVVDVIQGGAGTSTNMNANEVVANRGLEVLGYARGRYEFLHPVDDVNRSQSTNDVYPTAAKVATYVAIGGLLDALETLQRSFAAKAVEFADVVAMGRTQLQDAVPMTLGQEFGAYAETIDEDRRRLAEARALITEINLGGTAVGTGLNAPREYPELARAHLAEITGIPLVTSPDLVEATQDAGAFVQLSGVLKRIAVKLSKTCNDLRLLSSGPRAGFGDITLPAVQAGSSIMPGKVNPVIPEVVNQVAFEVIGNDVTITMAAEAGQLQLNAFEPVIVHRLFMSIDRLRNASLVLASKCVDGIVANREHLRREVLHSIGLATALNPYIGYAAATALAQEALATGAGVAELALEHGLVEPDVLAQILAPENLVG--------------
     28 UniRef50_UPI0001C16C0E Fumarate lyase n=2 Tax=Nost...   407    1e-112  1  47.2%   1:462   1:461     MSndFRIERDSMGDRQIPNNVYYGIQTQRALENFPISG--IKPLASYVDACLYIKKATAIVNGELSCIPLDISKAIVQATDEIL-GGKLRDQFVVDVYQAGAGTSHHMNINEVLANRALEILGDEKGNYQRVSPNDHVNYGQSTNDVIPTAIRLGGLLALTqlHPVLEKAIATLEAKAVEFQHIVKSGRTHLQDAVPVRLGENFRAWSHILSEHQNRIYTASGDLMVLGLGGSAAGTGMNTHPEYRKRVVEVLSQLLEIPLEPAPHLMAVMQSMGAFVNTSGAVRNLAQDMVKISHDLRLMDSGPKTGFKEIQLPPVQPGSSIMPGKYNPVMAEMTSMVCFQVMGYDQAIALAAQAGQLELNVMMPLIAYNLIHSIEILGNTIRALTDNCIQGIIANRERCLGYAEGSLALVTALNTHIGYLNAAAVAKESLETGKSLRQIVLERGLMTEEQLALVLDLEQM----------------
     29 UniRef50_Q87DC2        Fumarate hydratase class II...   406    1e-112  1  39.3%   2:464   8:462     -SDRYRIEHDSMGDLRVPIDALWGAQTQRAIENFPISGRS--MPQGFIHALGFIKAAAAKVNAELGLLPKSMAKEIEAAALDVAA-GRYDAEFPVDIYQTGSGTSSNMNANEVIATLA------MRATKGPIHPNDHVNLGQSSNDVVPTAIRISATLAVqrLLPALKHLRKMINKRARGLGSVVKTGRTHLMDAMPLTFAQEFGAWSAQIVSAEARLNDTLKRLHRLPLGGTAIGTGINTDPHFGRNAVKVLSALTGIHFESANNKFEGLAAQDDLVELSGQFNTLAVALMKIANDLRWMNAGPLAGLGEIELPALQPGSSIMPGKVNPVIPEAVVMVASQVIGHHTAVTVAGQSGNFQLNVTLPLIAYNLLESATLLGNVVMLLADKVIVGLKVRQDRVQEVLERNPILVTALNPIIGYEKAAVIAKRAYKEHRPVLEVACEESNLNPVELARLLDPAALTE--------------
     30 UniRef50_Q7UNE6        Fumarate hydratase FumC n=4...   403    1e-111  1  37.0%   3:467  71:543     --TDFRTERDSMGEVRVPQNAYYGAQTQRAVENFPVSGWQL--PPSMIAAMGRVKLACGIANRDLGKlsDGQVESMLSAAKEV-AEGQLADQFPVDVFQTGSGTSSNMNINEVLSNRAIEIDGGDraEEKSIHPNDHINMGQSTNDTFPTAIHVAAAYEIerLLPALRRMHESLTEKAQAWDKIIKIGRTHLMDATPLRLGQEFGGFARQIELSIARAEAARDAVLELPVGGTAVGSGINTHPEFGARVAASLSEQTGIAFIEAVNHFEGNANRDGLVDSHGGLKCVAQTLLGLANNIRWLGSGPRCGFYEVKLPTRQPGSSIMPGKVNPVMCESLMQVAARVIGNDTCMtsGGCGGNFQLNIMMPVMAHTILESIELLAGGVTAFIDFCLDGMEPNEEACEASVEQSLSMCTSLNPLIGYEQAAALAKEAFKSGQTIRELCKEKGILADDVLTEALDPWKMTEPQA-----------
     31 UniRef50_Q7V024        Fumarate hydratase class II...   403    1e-111  1  35.9%   1:463   1:461     MTKNFRFEKDSMGQIKVPSEALWGAQTQRSIINFSIGEELI--PIELIYSLTVIKRAAAISNFKLGLINNVKKDLIIEACTEIL-DGKHDSQFPLKIWQTGSGTQTNMNINEVISNIAALKTNSGLGSHHPIHPNDDVNKSQSTNDTFPAAIQivVTQIIKKLVPSIKELTKVLDSKSNKWKDLIKIGRTHFQDAVPISLGQEVSAWSKQLKDAEDALIISLNELCFLPLGGTAVGTGINCPKDFSKESIKSISEYTGLFFYKSKNHFSLMASHDRLAQVMGQIKILASALFKISNDIKILSSGPRSGIYELIIPKNEPGSSIMPGKVNPTQCEALSMVCTQVMGFEYAVSIANASGTLQMNEYKPLIGFNILTSIKLLNHAISNFRLKLVEGIQPNPKTIKANLENSLMLVTALVPKIGYEKAAEIANLAFNESINLKEATIKLGYLTANEFEDAINTNKMI---------------
     32 UniRef50_A7I3J5        Aspartate ammonia-lyase (As...   401    1e-110  1  49.2%   5:465   3:462     ----TRKEHDFIGELEISDDVYYGVQTFRALENFHMTGRRIKDYPFFVKAFAQIKKAAALANKEVGVLEAKKADAIAKAADRVIA-GEFLDQFVVDMVQGGAGTSTNMNANEVITNVALEMMGHKKGEYKYLHPNDNTNLGQSTNDTYPSSIKVATYAKMTDLLKAMEVLKKELEAKAKEYKDMIKMGRTELEDAVPTTLGNSFNAFASYIKSDIAAVKNARELMTYLNMGATAIGTGINCHPDYKFVVEKKLSEITGTEFKAAPDFIAATQDTADFVQVSGALKTAAVRLSKIANDLRLMNSGPRCGLGEIDLPKMQPGSSIMPGKVNPVIAEVVGEACYEVIGNDVTIMLCSERGEFELNAFEPGIAYALFNSLVILENAYITLANKAIKDIKAKPEACLKAVLNSVGIVTAFNPVIGYENSASIAKEALNTGKSVGEIAIERGLLTKEEVDKLLDPKSMLNP-------------
     33 UniRef50_D2R695        Fumarate lyase n=4 Tax=Plan...   401    1e-110  1  40.8%   3:465   2:472     --SEYRVERDSMGEVQVPAQAYYSAQTQRAVENFPISGWPL--PAALVHAMGLVKLACATANRDLGKldDQQVAALLEACREV-ADGKLDKEFPVDVFQTGSGTSSNMNTNEVIANRAIEILGGNRFEKepIHPNDHVNMGQSTNDIFPTAIHVAVAMQIkdLIPALERFQNVLATKAAEWDKIIKIGRTHLADATPLRLGQEIGGLARQMEMSIQRAKRAIDSVLELPAGGTAVGTGINTHPEFGRRVAEALSRETSIPFVEAVNHFEGNAQRDGLVECSGQLRTIASTLFNVSNNIRWLGSGPRCGFYEIQLPDRQPGSSIMPGKVNPVMCESMMQVAARVIGNDATVAfgATGGQFQLNIMMPVMGLATLESVKLLAASCRAFVDFCALEMEANPEACEAAVEKSLAMVTSLNPHIGYENAAAMAKKAFKTGKTIRELCREDGVLPESTLREALDPWSMTEP-------------
     34 UniRef50_Q043Y6        Fumarase n=61 Tax=Bacilli R...   400    1e-110  1  36.3%   1:463   2:458     VKKGYRVESDTLGPVEIPEKALWGPQTQRSKDNFHTGAL---MPIGIIRALLQIKLAAAQANIEAGTETEEKGRAIIEAIHQLLdnEELQPYFPLHVYQTGSGTQTNMNVNEVVAN-----LANQNHPGLNILPNDDVNMGQSSNDTFPTAMNLVATQALDDLKPSVKHLIKELKAKQDEYWTTVKVGRTHLQDAVPLTFGQELSGYVAALNHDLAYINELEETLYELPIGGTAVGTGLNAAPGMAEDISERLSRKYGHQFDVKTNKFFGLANHSGLNVVHGALKALAADMFKIAQDIRFLGSGPRAGLGELNLPANEPGSSIMPGKVNPTQAEAVTMACLRVFGNDTTITMAASQGNFEMNVFKLVMIAAFLESANVLSGTISSFANKMIHGMTVNKERMAKDVTDSLMTVTALSPHIGYHEAATIAQTAAKENTTLRTAALKSGLVTKEQYDKWMKPITMT---------------
     35 UniRef50_D2Q852        Aspartate ammonia-lyase n=2...   399    1e-110  1  47.7%   2:464  18:479     -AHQTRIEHDCIGSAEIPAEAYWGIHTLRAIDNFPVSGITVSDHPELIRAYAQVKQACARANGELSNINAYQAALIDRACEDV-ASGELNDQFPVDVLQGGAGTSTNMNVNEVIANRALELGHHARGEYDIIHPNDTVNKSQSTNDTYPAACRLALIGASGMLVDRTSQLVDAFHTLSERTMPIVKIGRTQLQDAVPMTFGQEFGGFASQLDADARLLSSQQTPLAVVNLGGTAIGTGICADARFRERAIRHLAELTDLPIRAADDSVGATSDVGDFVTLSGAIKRTALHLGKIANDLRLLASGPRAGFEEIHLPARQAGSSIMPGKVNPVIPECVNQCVFMIMGMDATISCAAEAGQLQLNAFEPVMLHALLTGMHTLANAMDTLREHCVSGITVNEQAGMDEVMRSSSLATALIGYIGYERAMTIAQEALVRNTTVREIAQKEKVLSPELLDSILDPHNLTH--------------
     36 UniRef50_D2L8A8        Fumarate lyase n=1 Tax=Desu...   398    1e-109  1  42.4%   5:471   1:464     ----MRQESDALGAKPLPEGALYGIHTLRAVENFPVSGQRLF--PEFLRAFALVKAACALANQETGHLDALRAEAIVAACREV-ADGRHDAQFPVDPFQGGAGTSTNMNVNEVVANRALELLGRAPGDYAFLSPLGHVNLHQSTNDTFPTALRVAALWLLKDLEAETARLQEAFQTKEAAFAHVVKVGRTELMDAVPLTLGMEFGAFAEALSRDRWRIFKCRERIKQVPLGGTAIGTGLGAPRDFIFRAAEHLRTLTGLPVSRAENLIDATANADPFVEVSGILSAFAANLLKISSDLRLLASGPATGIGEITLPALQAGSSIMPGKVNPVIPECVGQVALRVMANHQALTLAAGLGQLQINQFMPLLAHSLLESLRLLVQAARLFTDKCLAGITAGEARCRELVEKSHALATVLVPALGYAAVSRLLAEADAAGRPLAEHLAAKGMLAPEDAAALLAPKRMRKLGYETQD-------
     37 UniRef50_Q1IN60        Fumarase n=10 Tax=Bacteria ...   398    1e-109  1  46.2%   5:465   3:460     ----TRQEKDSLGYKDVPADAYYGIQTARAVENYPISGMR--AHATLIRAIAMVKQAAAEANLELDLIDARVAEALILAAKEMQ-EGRWDDQFVVDVFQAGAGVSFHINANEVIANRAEELTGGKLGEYKIVHPNDHVNYGQSTNDVFPTAMRLATLLELEKLYPVLDGLASAFGAKGKEFHDILKSGRTHMQDAVPMRLGQEFAAYAGAVRRAEKSVREQSELLRELGLGGSAVGTGINTHPEYREKAIRNLARISGQKLVVADDMRYAMQSNLAMASVSSALRNLSLEIIRISNDLRLIASGPNTGLAEINLPALQPGSSIMPGKINPVMPELAAMVCFQVIGNDTAVAFAVQAGQLELNVMMPTMAYSVLQSVTILTNMVRVFTEKCVIGITANAKRNEMYAQSTVSLATALNPYIGYAKAAEIAKESVATGRTIIEIAREKKYLSEEQIKEILDPAQMTEP-------------
     38 UniRef50_C9M5I1        Fumarate hydratase, class I...   395    1e-108  1  34.8%   4:466   2:458     ---EYRMEHDTLGSVEVPANRLWGAQTQRSLQNFPIGNESDRMPREIIKALLIIKAACAKINRQFGLVPQDIADAVASAALRLYENTPWED-FPLQVWQTGSGTQTNMNVNEVIARVASDAIGR------PVHPNDHVNRSQSTNDVFPSAVHLalLLAERRLLPAGENLAKRLESKARRYSRLIKIGRTHMQDATPVTLGQEIGGWAASVRRNLGMIAMSLELLRPLALGGTAVGTGLNAPANFGLLVATELTEFLGTRILSERNKFHALSSRGELCAFHGVVRTLAADVFKIACDVRLLASGPRCGFGELVLPANEPGSSIMPGKVNPTQCEAITQIAIQIMANDVAVSIASSQGTLELNTYMPLLARNVLSSCQLLADGMQSFAERCIVGITANEKQISRFVGQSLMVATALTPVLGYEKVAALAKLAYENDSSIRETVLADGALTAEQYDQLMMMDRLVGRS------------
     39 UniRef50_D2LUT1        Fumarate lyase n=1 Tax=Baci...   394    1e-108  1  41.8%   2:463   3:460     -SNEYRTERDPLGKVKIPKRAYYGSQTQRAIENFQISNKHL--PRSFIKAQGIIKVAAAKVNIDLGMLTKNLGEAIITASEEVI-NGEWDDQFVVDVYQAGAGTSQNMNANEVIANRANEILNKGTH-AERIHPNDHVNMSQSTNDTFPTALNIAALEGIHelIPAIDQLQQALNRKSEELMSVLKSGRTHLHDAVPMKLGQEFAGYAETIRSLYEEIKQNSEELYEIGLGGNAIGTKVNLHESYAKKVIAEVSKRTNYPFREPTNIFSFMQNRNAPLRVMGSLKELSVHLIKITSDLRLLSSGPRTGLAEITLPSVQPGSTIMPGKVNPAILEMTHMVCCQVIGYESTLSTAVMSGQLEINVMMPIIAYTLLESIHILANAITSLVEKCITGIKANEATCRKWMEESLSLVTGLSPSMGYDLASEIGQQAEEENKTIKQILIDKGLNTKENI-SAIDPSNFI---------------
     40 UniRef50_C8W2Y3        Fumarate lyase n=3 Tax=Clos...   393    1e-108  1  42.0%   3:478   2:474     --TNYRVEKDLLGELKLPRAAYYGINSLRASQNFAVSGYGVN--KHLLRALAEVKLAAAQANLQASLLPAETARAICSAAQEV-AEGGLAEQFIVDALQGGAGTSTNMNMNEVLANRAIELLGGQKGDYDLVHPLNKVNLSQSTNDTYPTALRIAAIRLVLDLSEALAELQTSLQEKEAQFAGILKLGRTELQDALPITLGQEFGAFAEAIARDRWRLYKVEERLRQINLGGTAIGTGLNAPRRYIYQVVEELRQITGLGLARAENMVDLTQNADIFAEVSGLVKAAAVNLCKIAGDLMLLAAGPAGGLAEINLPPRQAGSSIMPGKVNPVILEAVIQVSWQVMGADQTICQACAGGRLELNAFLPLIAHNLLHVLEMLAKTARVLNSECIRGITANEERCRRWLEESNVLVTALVPYIGYEQATSLAQQAREENKTIVELVQARNLLTIEECQIIAAPRELTRPGIAGARQLANRFK
     41 UniRef50_Q0BTB3        Fumarate hydratase n=4 Tax=...   393    1e-107  1  37.4%   6:470  35:497     -----RQEFDSMGTVMVPANRYWGAQTQRSLKHFSIGNDK--MPKEVYHAYGYVKKAAAIVNTKAGRLADWRAKVIIQAAEETIA-GKLDDNFPLYVWQTGSGTQSNMNVNEVLSNRAIQLLGGTLGAQAPVHPNDHVNMGQSSNDTFPTAMHIATVLELdvLLPQAEAFAASLEAKASQWMNVVKTGRTHLQDAVPLTVGQEWSGYAQQVRDAIANVVASKAGLYKLAAGGTAVGTGLNAPKGFGHDIAQTIAELTGKPFITAPNKFSAQGSLDAMVATSAALRGLAVALMKIANDIRWLASGPRCGLGELLLPQNEPGSSIMPGKVNPTQCEAMVMVCIQVIGEDNAVAFAGSQGNFELNAMRPIIINNVLHSARILGDMCEKMRVYSIEGTELNRARIDASVDQSLMLVTALSPVIGYDNAAHIAEAANADGSTLREAALKSGKVDEATFNRVVDPQKLVGEGVAGA--------
     42 UniRef50_A9WAB2        Fumarate lyase n=19 Tax=Bac...   392    1e-107  1  44.9%   1:470  13:480     MAEGYRIERDSLGEMQVPANALYGAQTQRAVLNFPVSGMR--PYPAFVWAQTMIKRAAAEVNRDLGLLDPQIANAIIQAAEEVLA-GQHADQFVVDPFQAGAGTSHNMNVNEVLANRANQILGYSLDdkKPVSPNDHVNMAQSTNDTIPTAIRLGCLWRLPELIAAIDDLADALEQKAIEFDDVVKSGRTHLQDAVPVRLGQEFGAYAKAVRNDMERIVTAANRLRRLGIGGTATGTGLNAHPEYHSRMVAKLSELTGHELVSSGNLFESMQSMADPADFSASLRTLCITLGRIANDFRLLSSGPATGLDEIRLPAVQPGSSIMPGKVNPVLAEMLNMACYHVQGCDLTVALAAQAGQLELNVMMPIIAHNLFEMMHVLIGAINAFTTKCVVGITANREKAAGWLAKNAILVTALNPVIGYLNGAAVAKEAMATGKTIKEVVVEKGLLTAEQVDELLDVRKMTEGGIQGI--------
     43 UniRef50_C7RF85        Fumarate lyase n=2 Tax=Anae...   392    1e-107  1  37.8%   4:463   2:454     ---DKRIERDSLGEIEVDNDKYWGAQTQRSFMNFPKGLDL--MPKEEIRALTLIKKAAAIVNFELGKIDEERKNLIVYAADRIL-DGDFDDQFPLTVWQTGSGTQSNMNVNEVIAHIANEKCGENL-----IHPNDHVNKSQSSNDTFPTAMHMalNLLENELLPEIDEFIGGIESKAKEFEGIIKTGRTHLQDATPIALSSEIRAYSEIIRRDKAALIDLMEDLRRLPIGGTAVGTGLNAPEAYSSKMISTLEKLSGLRLIEDSNKFVGLSSKQAMARVHSALKVLAEDLNKIANDLRFLSCGPRTGIGELILPTNEPGSSIMPGKVNPTQVEMMTMVAIQVMANDTAISIANASGQLELNTYMPLVIYNMVKSIKLLTKAMTSFRIHLIEGLVANKEKIEENLDKSLMLVTSLSPLIGYDKAAELAKFAHKNNLSLREANKELGFVSDTDFVKTVDPREMI---------------
     44 UniRef50_B8DTH4        Aspartate ammonia-lyase n=1...   392    1e-107  1  43.4%   2:462  29:488     -AAETRLEHDVIGTMEIPADVYWGIHTQRAMGNFTVTGIADGSHTALIRAYATVKRACAIANYQLGMLDARKAHHIEQACLEI-ENGALADQFPVDVLQGGAGTSLNMNMNEVIANRALELAGKPRGDYGYIHPNDDVNRSQSTNDTYPAACRLAILQGLKPLREATQRLREAFHMQADRHSNDIKIGRTQLQDAVPMTYGQEIHAWASFLATDLEAMNTLAKRLCVFNLGATAIGTGICADLRFRHTATTVLAEITDLPITAASDPVAAVTDTSSYIEASAVLKNLAVHLKKAADDLRLLNSGPRCGFGDLTVPPRQAGSSIMPGKINPVIPECVDQCCFTIFGMDVTVNWACAEGQLQLNAFDPLIIHEILTAMTIAINAMDMFRTKCVDGLRINVEQGRRDAEMSPSICAALNGKIGYEQAMSIAKEAVATGKSVREVAGERTDADRTELDSLLDIAAM----------------
     45 UniRef50_Q7U8I1        Fumarate hydratase class II...   388    1e-106  1  35.9%   1:465   1:463     MGQPMRQEHDSIGGVDVPAAALWGAQTQRSLNNFAIGHQKI--PAELIHALARIKQCCAAVNGRHGLLNDQQVALIERAGQAIQT-GQQDDHFPLSVWQTGSGTQTNMNVNEVISNLAAQESGENLGSHRPLHPNDHINRSQSTNDVFPAAIHVAAALQLqeLLPELKRLIASLDAKAVAWQDIIKIGRTHLQDAVPLRLGDEVSAWRDRLSDGAHWLTTAHQDLLALPLGGTAVGSGLNTPDRFAHEVCAELASRTGSDFQPADNLFAVMAGHDSLVQTMAQLRRLAVTLLTIANDIRLLACGPRAGLGELLLPANEPGSSIMPGKVNPTQCEAMAMVCTQVIGMDAAVAAAGAGGHLQMNVYKPLIGYNLIEGIRLLQDACRCFRLNLLTGMEADRDRIAFYVERSLMLVTALTPEIGYEKACAIAQHAHRDGLTLREAAMQSGAITDERFDQLIDPAAMASP-------------
     46 UniRef50_C7DHL7        Fumarate lyase n=1 Tax=Cand...   386    1e-106  1  41.3%   4:463   2:459     ---PYRTERDVLGKVKIDSSSYYGSETKRAIDNFPVSGITVSPD--FIHYYALIKKAAAKANLKSGKLSQERASAIIKAAEEV-ASGKFADQFPVDVFQAGAGTSTNMNLNEVIANRAIELLGGRKGDYKKVHPNDHVNMSQSTNDTYHAAMRVAANATMRrlIPALKALAATFQKKAAEFRNVVKIGRTHLQDAVPITLGDEMSGYYGAIEYAIEGLEQSLAQLSELPLGGTAVGTGINISKDYKANVIRELSAITRIKFKPARHMYATMQQEYAELAASNAIKTAAITLGKIANDIRLLGSGPRAGLNELILPPVQPGSSIMPGKINPSMAEMLNMVCFEVYGNACTIEQACSGGQLELNVFMPIIAFDMLYSIKILSNAVNAFNSRCARGIKANTKAINANLERNLSLATALSPYIGYAKAADIAAKAYREGKTVKEVCLAEGIMPKQELDRILNPKNLV---------------
     47 UniRef50_C4JP97        Fumarate hydratase n=16 Tax...   383    1e-105  1  31.4%   1:465  76:500     MASGTRTETDAFGEVQVPGDKYWGAQTQRSLGNFDINQPQDRMPPAIVRAFGILKGAAATV---------------------------------------------NMRYGLVISNRAIEILGGTMGSKKPVHPNDHVNMSASSNDTFPTVMHIavLETEETLLPALKSLREALQKKVERFEKLIKIGRTHLQDATPLTLGQEFSGYVAQLDRNIDRIQNTLPDLRLLAQGGTAVGTGLNTFKGFDEAIAEEVTKMTGTEFKTSPNKFEVLAAHDAIVEASGSLNTLACSLFKIAQDIRYLGSGPRCGLGELILPENEPGSSIMPGKVNPTQCEALTMVCSQVMGNHVAATVGGMSGQFELNVFKPLMIRNLLHSIRILGDGMKSFEKNLVVGLEADEKRIGSLLHESLMLVTCLNPVIGYDMASKVAKNAHKKGLTLKQSAMELKALSEEDFdeLLFPMDLISP-------------
     48 UniRef50_Q8FQP8        Fumarate hydratase class II...   383    1e-105  1  40.1%   2:462   7:464     -EQEFRIEHDTMGEVKVPAQALWRAQTQRAVENFPISGRGLES--AQIRAMGLLKAACAQVNKDSGALDAAKADAIIAAGKEIAT-GKHDAEFPIDVFQTGSGTSSNMNTNEVIASIA-------KANGTEVHPNDDVNMGQSSNDTFPTATHVAATEavNDLIPGLKVLHESLAKKANEWDSVVKSGRTHLMDAVPVTLGQEFGGYARQIQLGIERIEATLPRLGELAIGGTAVGTGINTSADFGGKVVAELVELTGvqLQEAANHFEAQANRDALVEFSGAMRVVAVSLYKIANDIRLMGSGPLTGLGEIQLPDLQPGSSIMPGKVNPVLCETATQVSAQVIGNDAAVAFAGSQGQFELNVFIPVMARNVLESARLLANTARVFATRLVDGIVPNEEHMKQLAESSPSIVTPLNSAIGYEAAAKVAKAALAEGKTIRQTVIDMgkLTEEELDKRLDVLAM----------------
     49 UniRef50_C5CDV4        Fumarate lyase n=1 Tax=Kosm...   383    1e-105  1  39.5%   5:457   1:448     ----MRIEKDALGKLEIPDDVYWGIHTARALKNFPSTGEKI--DEEFIRCYGYIKKSAAFLNKKLGFLETKIADAVIQAADELIS-GSLMKWVVVDPLCGGAGTSINMNINEVIANRATEILGGKLGEY-IVHPLDHVNLHQSTNDTFPTAGKMATIALLKQLVENVTNLQDSLQKKEAEYRKMIKPARTQLMDAVPISLGQEFGAMAEAISRDRWRLYKVEERIRMVNLGGTAVGTGIAADRKYVLSIVETLRTVSGIKIAKAENLIDATQNMDVFAEIHGLLKALATNLIKISNDIRLLGSGPGSAIGEIKLPKLQAGSSIMPGKINPVIPEYVVQLSLAVLGHDAIINFAVSSGNLELNAFVPEIIHYTLKSLRFLTIAANSLANYILK-IEANPEKMRENLLSSSAILTPLITTYGYDKVQEWIELSSKTGKNLWEIVKDSLGEEAEKFKAKL---------------------
     50 UniRef50_Q72B70        Aspartate ammonia-lyase, pu...   383    1e-104  1  41.9%   2:466   6:467     -QDAIRIEHDLLGDCAVPRTALHGAHTQRALSNVALSGRPL--HPEIIRAFGAVKRACARTNMNLGHLSREVAEAIIMACDEL-EDGGLGEHIVVDALQGGAGTSANMNVNEVLANRAEEMLGGTRGQYQLVDPLAHVNLHQSTNDVFPTAVRIAALRLLARLEPAIAALQSAFQTHEASFAQVVRLGRTQLQDAVPMTFGAACGAWAEALSRDRWRVFKCSERLRVVNLGGTAIGTGIAAPRSYILSVVDRLREDTGLPLARAENLMDATQNVDAFVEVSGILKAHASNLLKLSSDLRLLASGPGGGIGEVVLPPVQAGSSIMPGKVNPVVCETVAQAAMQATANDLAITLSAQHGQLELNAFMPLIADALLHGIELLTNACDLFRTRCVEGLHPDTETCARHVSTSTATLTALVPEIGYAAASEMARHMREHGTDVFGAAKATGLIDEDRLARLLSPERLVALG------------
     51 UniRef50_C4QFA0        Fumarate hydratase n=1 Tax=...   382    1e-104  1  34.5%   2:462   6:488     -SQRLRVVEDSLGKINVPLERYYGAQTARSLGNFNVCTRSDTMPLQIVYSLAMIKEVAACTNFKLGRISSKLSDAIVKACREVYH-GQHDNEFPLVIWQTGSGTQTNMNVNEVLSSRASELIDGSRSSRLTVHPNDHVNLGQSSNDIFPTAMNLSIaeTAWKVLPSLNHLINVLKIKMHEFMNVIKIGRTHMQDAVPMSVGQELSGYVSQLQQAVDSIKSQLPLICHLAVGGTAVGTGLNCSKGFDEELCVSLTQLTdlIFKPAENKFAALAGHDALLQLSGCFNTTATALMRLSNDFCLLSSGPNCGLSEFVLPANEPGSSIMPGkvNPTQCESLRMVCLQIMGNHFTTSMAASQGQLELNVCKPLIAANLLHTCELLTDSTRCFADKCVRDLQLNREKIQEYVDKSLMLVTVLTPHIGYDLSAKLVQHASKFKKGLRESAIELNLLCGEKFDEIVKPMEM----------------
     52 UniRef50_B4IYT9        GH16362 n=2 Tax=Drosophila ...   380    1e-104  1  31.3%   3:465  21:483     --GDTRLEYDDIGAVNIPLDRIFGPTTMRSVMNIPIGGMEERIPRPIIIAMGILKKAGAEVNKEFG-LDSCISGAISSAADDVISGKLYDehFPLTIWQTGAGNQTNVNVNEVIGNRAIEIMGGQLGSNYPVDPNLHVNMSQNPNDCFASATNITVAMQleKLFPSLRLIIDALEKKEILWKNVIKVGRAHLMDEVPLTLGQEFSGYKQMMINCQTRLYSSMERLYQLSLGAATLCETPNCQPDFGYQCVKEIEVITGLPFVSAPNMHEALGARDSLIEVHGELNCIAVSTMKIANDIRFLGSGPRCGLGELILPSNEPGSSIMPGKVNPTQCEALTMICAQVMGNQVAVTVGGFNGHFELNSFMPLIASNVLRSIELLSDGLQAFVANCLEGAKPNSNKIDKFLKNSLMLATALNPYIGYNKTVQLATAALQNGTTLKQEALKIG-ISEFEFESWVRPSEMLGP-------------
     53 UniRef50_D1BPM6        Fumarate lyase n=3 Tax=Veil...   380    1e-104  1  38.5%   4:458   2:449     ---ETRIEYDSMGPVEVDARRIYGPQTQRSFNNFKIGDHRI--PIEQIKALALVKKACALTNAKCGAVTEEKAKLIAQVVDEIV-DGKWDEEFPLTVFQTGSGTQTNMNVNEVIAHRA-----KQLDESNPLHPNDDVNRGQSTNDTFPTAMHICAyeITKRVIPALDGLIESFEKLQKKGKGLQKVGRTHLQDATFIMVDQEISAFVDGLKTAKTMLVQNADHLLDVALGGTAVGTGVNTPKGYLDVMETVLPEVTGAPFRVKNNKFQGLALKDAFMMAHGALNTLATTLFKIANDVRFLGSGPRCGYGEWHLPENEPGSSIMPGKVNPTQCEALTMVCAQVFGHNTTMTLCAGSGAFQLNVYMPIMIYDFVESCRLLADAMNSFTTHCIDGVEFVPEKLNFFVEQSLMIATSLTPYIGYDKSAKVVKEAYKRGCSIKEIILEEKLMTEDEFAEAVR--------------------
     54 UniRef50_C8P033        Fumarate hydratase, class I...   379    1e-103  1  33.3%   9:465   5:454     --------EDKFGKIDIPEGALWGVNTQRSLQNFPIGQET--MPESLIEALIVLKKVSAKVHRVHHKMDEDIAKVIVEACDYLL-DGDLKEAFPLSIWQTGSGTQTNMNVNEVIAH-----LANTRFHGHHVHPNDHVNQGQSSNDIFPSAMHISTVLLVksLMLSLEDMIETFDALIDQYGLVMKTGRTHLQDATPITFGQELGAWRHMYQEGLDQLNQCLESLQPLAMGATAVGTGLNSYEGFDQAICDELNQMYHESFRPSVNKFHAISSKDSFVFLQGALAAIASNSLKMANDIRFLASGPRCGLGEISMPENEAGSSIMPGKVNPTQCEALMMVCAQVMGNQTAVTVGAALGNFQLNTFMPLIIHNTTQSICLLSDALNSFNLRCLQGIEVDKEKMSDNLHKSLMTATFLNRKFGYDHTAKIVNQAHQEGKSIKTVVVESGAMGDDEFDAFFDYQKMIQP-------------
     55 UniRef50_Q7U0N6        Fumarate hydratase class II...   378    1e-103  1  39.5%   2:462   7:463     -SANYRIEHDTMGEVRVPAKALWRAQTQRAVENFPISGRGL--ERTQIRALGLLKGACAQVNSDLGLLAPEKADA-IIAAAAEIADGQHDDQFPIDVFQTGSGTSSNMNTNEVIASIAAK-------GGVTLHPNDDVNMSQSSNDTFPTATHIAATEavAHLIPALQQLHDALAAKALDWHTVVKSGRTHLMDAVPVTLGQEFSGYARQIEAGIERVRACLPRLGELAIGGTAVGTGLNAPDDFGVRVVAVLVAQTGleLRTAANSFEAQAARDGLVEASGALRTIAVSLTKIANDIRWMGSGPLTGLAEIQLPDLQPGSSIMPGKVNPVLPEAVTQVAAQVIGNDAAIAWGGANGAFELNVYIPMMARNILESFKLLTNVSRLFAQRCIAGLTANVEHLRRLAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIRQTVIDRGLIGdeDLDRRLDVLAM----------------
     56 UniRef50_B7HRS6        Argininosuccinate lyase n=6...   377    1e-103  1  19.4%  20:478   2:453     -------------------SKLWGGRFTEEAEAWVefGASISFDQQLVNQDINGSIAHVTMLAKQGIVTKEEAEKIKIGLQYLLEEAKQNKL---------HFSVEAEDIHLNIEKMLIEKIG---------EVGGKLHTGRSRNDQVATDMHLYLNEKVEHIIKATKQLQTVLVHQAENNIETIMPGYTHLQRAQPISFAHHILAYFWMLERDVNRYEDSLKRINISPLGAGALAGTT------FPIDREYSAELLGFNGI-YENSLDAVSDRDFILEFLSNSSMLMMHLSRFCEELILWSSQEFQFIE--MSDQYATGSSIMPQKKNPDMAELIRGKTGRVYGNLFSLLTVMKGLPLAYNKDLQEDKEGMFDTVK-TVEGCLHIMAGMLETMTVNKEKMGQAvsNATEIADYLapFRQAHevGKLVLHCTQKGIYLVDVPLEtsSLFEEDLYEVLSPYAAvgTGFEQIEKALEKAK
     57 UniRef50_A9BSS6        Fumarate lyase n=3 Tax=Prot...   375    1e-102  1  34.7%   2:468  13:477     -QAHTRIEHDAFGPVHIPADRLWGAQTQRALELFTIGEER--FPQGLYRAFGLQKLAAARANRRLGVLDDERGAAIEAAAAELR-DGLLDAHFPLTIWQTGSGTQTNMNANEVIANRANQMLGQPPGTRSPVHPNDHANASQSSNDSFPTVMHLaaLELRDHLLPALEQLQQRLQERALAFAGVLKVARTHLMDAVPMTLGQSFETFAHQVGHGIHRLQATQPRLWSLAQGGTAAGTGLNAPSGFDRVFCEEIQALTGLAVTPNPCKFEGMAAHDALIEVSGALNVVAGSLAKMANDIRLLGSGPRCGLGELVFPDDGLSSSIMPGKRNPTVAEVVVQAAYQAMGHHLTVTLAGSAGHFELNVAKPVLIHHLLRAMLALGDASRVFAEKLVAGLQAHTERLEQQVSHSLLQATALNPVLGYDAVARITREAMARGIAPRQAAVALGLITAAEYDRLVDLRAMAGLPPA----------
     58 UniRef50_C6VJS2        Aspartate ammonia-lyase n=1...   374    1e-102  1  43.7%   5:478   1:466     ----MRIEADCIGKLAVPDDALYGIHTLRAVHNFPITTEL--MHPLIMQSLVQIKKAAASVNAAAGTLSNDKAHAIIAACNQLLL-GRYADNFIVPAIQGGAGTSANMNVNEVVANLAHRLM-----PAVAVHPNDDVNQSQSTNDTFPTAGKMALCMQLPGLLTALSRLVQTLLVKSQRYQDAIKVGRTQLEDAVPTTYGRTFHAYYQLFKRDLTRVRQAGEHLRIVNLGGTAIGTGINATHTYQQQILVKLNQNTDLDLVAAPDLIDATQNCDLFVEFSAAMKTLAVDLSKFSNDLRLLASGPQAGFGELNLPAQQAGSSIMPGKINPVIPEVVNQVAFEVIGHDTTVTMAAEAGQLELNAFEPIMLRALLTSEQHLQQALTTLVDHCVRQLTVNRQRCADQVAHSAITATVLAPYLGYETTTALIKEALTTNQAIPELLHRRRLLSDALVEQLFSPAGLTQPRPEVIEQLRAVAK
     59 UniRef50_A9A1H7        Fumarate lyase n=4 Tax=Arch...   374    1e-102  1  41.2%   4:457   2:452     ---KFRLDQDSLGKVKIPSDAYYGAFTGRAIKQYHVTGNT--SHENLIKSFVMIKRSAAVANMKTKAIDTKRGKAIVSACDKILA-GKHVDQFVVDMINSGAGTAFNMNSNEVISNVALEILRKKKGQYEFLHPNDHVNMSQSSNDTYPTAMHVAILMNLKETIPAIDILIKSLSKKAKQFSSFKKIGRTHLMDALPVTLGSEFAAYVTSITKARNELVASQKELQNVALGGTAVGSGANTPKGYRKIAIAELGKISKLPLRPEKDMQHGLQSKYAVANCSGALRNLALEIGKLANDIRLMASGPIAGLAEIGIPAVHAGSSIMPGKVNPSLAECMNMICFNIIGNDTAVSYAAQGGQFELNVMLPGMLKCMLESTDMIKNFLPIFSANLIDGLTANKDKLRADIENSPVIVTLLTPKIGYLKSAELFKESLKTGKTIRELVVSKKLMTNKEIDSLF---------------------
     60 UniRef50_C0N7P0        Lyase superfamily n=1 Tax=M...   372    1e-101  1  37.4%  14:465   4:449     -------------SSHISQHAKWGKQTTIALKHFRVGTET--FPAELLHAYGMVKYCAAAVNQQQDLISSDIASAIMTAAQALIK-GELDQHFPLSVWQSGSGTQTNMNVNEVLANIAN----HNLASSNSVHANDHCNRSQSTNDSFPTALHIACTLLirELLPALERLAQRFSEKADTWHSLLKSGRTHLQDATPITLGQEFSAFAFQIKQATTSIKQQLTVISELTIGGTAVGTGVNTVSGFSEAFCQQLNDLTGLQFQPTQNHFASQASHDAVVQLSGSLNTLATALNKIASDIRLLASGPRCGLAELHLPANEPGSSIMPGKVNPSQCEMLNMVCAQVMGNHTTITVAGAQGQLQLNTFKPVMAYNILQSLRLLTDAIVSFDTFCVQGIQANTPQLAAMMDKSLMLVTVLTPLIGYDKAAEIVKIAAQNNTTLREEVLNAGLLTQNEFDQLIRPEQMVSP-------------
     61 UniRef50_C1FHH1        Aspartate ammonia-lyase n=6...   371    1e-101  1  47.9%  17:465   3:449     ----------------IPADALYGIATARAMDNYDISGVKVRDYPEFIRAFAHVKRACATANGRLGLLPGDVVDAIVAACDELIQSDRHHAHFAVDMVQGGAGTSTNMCANEIIANLAAIHLGEPVGDYSRVHPNDHVNMCQSTNDAYPSAAKLAVVFKHVAVTHALEDLIASLRKKAIEFEHVVKMGRTQLQDAVPMTLGQEFRSFASSLAADLTFMQRNVDQLYELNLGGTAIGTKICADASFAEASVAALSEQTRLPLRSPEDFIEASSSTSSFLLFSNILRRVAVKVSKICNDLRLLSSGPRCGFNEINLPAAAPGSSIMPGKINPVIPEVMNQVCFQVIGTDHTIASASEAAQLQLNVFEPIIIYNLLNNMNLMERGLNTLRTKCIDGITANPERCKELVDNSIGIVTALLPLLGYKKATAVAKEALETGRPVAEI--ASRFADPREVAEMLRPEAMTHP-------------
     62 UniRef50_Q58339        Adenylosuccinate lyase n=23...   370    1e-101  1  19.3%  18:478  17:458     -----------------PIDYRYGTPEMR----------KVWEEENKLEKMLKVEAALAKAQAELGLIPKEAAEEINKKASTKYVKL--------------------ERVKEIEKQTKHDVVarALAEVCEGNAGEYIHFGATSNDIVDTANSLLIKESIEIIEDKLKQLRDILLDKAEEHKYTVCVGRTHGQHAIPTTYGMRFALWAAEIDRHLERLKEAKKRICVS-MITGAVGTMAAMGEKGLE-VHKRVAEILGLEPVLISNQVIQ---RDRHAEFVFLLALIAQTLNKIGVTVRSMQRTEIGELEEEFDPTKQTGSSTMPHKRNPITFEQICGLS-RVIKSLCIAEMDNIPLWEERDLTNSSAERCIFAEVCVLTDHILTLAIKGVKKLKVNKENVERNLELTKGLIMalarGMGRQTAHEIVRqaYEEKRHLKDILLEnkYITKEELEELMNPKTYIGLAPQIVDEVIKTLK
     63 UniRef50_Q978Q5        Fumarase n=4 Tax=Thermoplas...   369    1e-100  1  42.6%   5:457   1:450     ----MRTERDVIGEIQLEDTVFYGINTARAKENFRITG--LTSDSDHIVSIAQIKKAAAMANAEAGALDKEKAEFIEKACDEIIS-GRYHDQFVIDVYQAGAGTSFNMNANEVIANVALTLMGKNKGDYSVIHPNDHVNMSQSTNDVYPTMMRLTVTKKVKKLKEAISDLIESLEKKSKELRGIPKPGRTHLQDAAPVTVGLEFSAYAYAIKKDRDEITDALDYIMELNIGGTAVGTGINTSKNYQENVVKHIAEITRENFRKSSNLMGIMQFMTDFSRVMNAVTNLALDIEKIANDIRLLYSGPGTGIHEIIIPAVQQGSSIMPGKINPSIAEAMNMICHSVIGAQQAVNMSVQAGQLELNVMMPNIDYELTRSIDIMRNGLIMFKEKLIDGIKANVNTCREHLANSFGSAALLNPYLGYDNVAKIVREAVETGKSIKSLVLATGKITEEQYMKIM---------------------
     64 UniRef50_A3Y7G3        Hypothetical aspartate ammo...   369    1e-100  1  40.6%   5:465   1:458     ----MRIEHDALGERQLEETLYYGIQTLRAKENFDISGKTISNIPSFVESIIQIKKAAAMANHKAQVLDENLCKAICQAADEMLANPD-PANFVVDIYHGGGGTSANMNINEVLANRANEIMTGHKG-YDQVHPNTHVNMGQSTNDVIPAAMKMAVFNSLNDLESVLTNFVISLQKKETEFNDVVKLGRTCFQDALPTTLGQQFSGYRNGFERMISELHDIKASCLELPLSATAVGTEFGTFPGYKSFLFSALEEVTQTRWTVEHNLFDGLQNADIWIKVSAIIKAIALNLNKLAGDLRLMSSGPRAGLGEITIPAVQPGSSIMPGKINPVMPEMAMQVYFRVLGNDLAITRACE-GELDLNVWESLILNCVSESCDLLGACMPLLASKCIDGIKANAEKCQQDAENSLALSTVIATLFDYQTASKLAKQADAEKKTIKQVVIESGILSPTEAERYLSPLTMTSP-------------
     65 UniRef50_D1SP80        Argininosuccinate lyase n=1...   368    1e-100  1  18.6%  12:478  34:492     -----------FGemNILRRGRLGNSIKEDVAKYTTS---LSFDKEIFEADILCDIAHVIMLYEQGIIKKDDAKKIIEGLKEIYKKGMENLNLDPSLD----------DIHMVIENELIKKLGE--------DVAGRMHTGRSRNDEVATDLRIALREKVLMIAKSLIEMLKDILELAEEHKETLTVGYTHLQHAQPTTFAHHLLSYVSAIERDILRLLDAYKRINISPLGCGAMATT------GFKINRDRTKELLGFD-ALIENSMDGVSARDFIVETMADLAILGTNLSKICEELILFSTYEFGTVE--IANEFCSTSSIMPQKKNPDVAEIARAKLSKLNGNLVTALTILKALPNTYNRDLQEISPHLWDSVYTTIDTI-KMVHGMLKTIKVNKERMKELANANYSTATELapFRTAhiVGEVVRRSIEEKKDMIEIIYenLKVGDEKIKKALDPYENvgPAPKEVERRIKAFK
     66 UniRef50_Q010D6        Fumarase (ISS) n=3 Tax=cell...   368    1e-100  1  35.1%   2:465  80:517     -EGETRRESDTMGVVDVPMHKLWGAQTQRSLENFKIGGEK--MPIAIVRSLAIVKYAAATVNEREGRL-------------LGSCEDHWMNTFPLVRVPNRIGTQTNMNLNEVICN-------------SPIHPNDHVNMSQSSNDTFPTAMSIATAHEveRLIPALKMLQEALHVKVLAWGDIVKIGRTHLQDAVPITLAQEFSGYEQQVKNSLLRAKGALVHLLELAIGGTAVGTGLNAPPRFGENMAAEISMLTGLPFVSAPNKFEALAAHDAQSTLSGMLKTIAISLLKIANDIRLLGSGPRAGLGELCLPENEPGSSIMPGKVNPTQCESLMQVCAQVIGNDLAVTIGGSasHFELNVAKPLIAHNNLNSIALLSDSLESFTKNCVVGIEPNMERIDALMRSSLMLVTSLVPKIGYDKAAKISKKAHAEGLTLREAGVQLGLLTNEQFDEWIRPDEMTRP-------------
     67 UniRef50_A6UW73        Argininosuccinate lyase n=1...   364     3e-99  1  19.0%  16:474   7:456     ---------------NILRRGRLGSSTKKEVMNYMTS---LSFDKEIFESDIFCDIAHTKMLMEQNIILEEDGIKIINELKKIYNNGMDCLNLDPSLD----------DIHMVIESELIKNLGE--------DVAGRMHTGRSRNDEVATDLRMALRDKILTILKLLINMQKNILNLAKEHKETLTIGYTHLQHAQPITFGHHLLSYASPMERDILRLIDTYKRVNICPLGSGAFATT------GFNINRNATKELLGFDSV-IENSMDGVASRDFILETMANLSILGTNLSKICEEMVLFSSCEFGTIDLAN--EYTSTSSIMPQKKNPDVAEIARAKLSTLNGNLVTVLTILKALPNTYNRDLQEISPHLWDSVYTTIDT-LKIIDGMISTIKVNADRMKELTEKNYSTATELapFRTAhiVGEVVRLSIENNKNMNEVIRdnLKLDDSKIEKALNPMENvgPAPEEVERAI----
     68 UniRef50_Q3A9W6        Argininosuccinate lyase n=4...   362     2e-98  1  18.6%  21:478   2:452     --------------------KLWGGrtDREMRDFHAS---IHFDWRLYEEDIRGSIAHVTMLARQGIITNEEKEKIIGALTEILEEIKAGKVD---------FSPEAEDIHLNIETLLIKKIG---------DVGKKVHTGRSRNDQVALDTRLYVKKEGTAIIALIKELQETLINLAEGHLNTIMPGYTHLQRAQPVTLAHHLLAYFWMFDRDRSRFYDCLKRADRSPLGAGALAGTT------LPLDREFVSELLGFNGV-CENSLDAVSDRDYILEFLFAAATTMMHLSRFSEEIVLWNSKEFSFVE--IDDRYATGSSMMPQKKNPDAAELIRGKTGRVYGNLMAVLTMMKGLPLAYNKDMQEDKEPLFDTVDTL-KGSLRVFTGMLKTIKFNQGAMYKAALKGFLNATDlvPFREAHRigELVLKAEKTGRELLELSLDesPLIEEDIYEKLKIENVlgPAPQAVIEQLRQAR
     69 UniRef50_Q58201        Argininosuccinate lyase n=3...   361     4e-98  1  18.3%  15:478   1:455     --------------MNILRRGRLGNSIKEDVAKYTTS---LSFDKEIFEADILCDIAHVIMLYEQGIIKKEDAKKIIEGLKEIYKKGMENLNLDPSLD----------DIHMVIESELIKKLGE--------DVAGRMHTGRSRNDEVATDLRIALREKVLIIAKSLIKMLKDILELAEKHKETLIVGYTHLQHAQPVTFAHHLLSYVSAIERDILRLLDAYKRINISPLGCGAMATT------GFKINRERTKELLGFD-ALIENSMDGVSARDFILETMADLAILGTNLSKICEELILFSTYEFGTIE--IANEFCSTSSIMPQKKNPDVAEIARAKLSKLNGNLVTALTILKALPNTYNRDLQEISPHLWDSVYTTIDTI-KMVHGMLKTIKINKERMEELAKANYSTATELapFRTAhiVGEVVRRSIEEKKDMIEVIYenLKVDEEKIKKALDPYENvgPAPEEVEKRIKVFR
     70 UniRef50_Q0AGL1        Argininosuccinate lyase n=9...   360     5e-98  1  16.1%  19:478   8:456     ------------------WSGRFSEPVALLVQRYTAS---VGFDYRLAEYDIQGSFAHARMLAATNIIPQTDLEAIEKGLTQIWEEIKNGQFEWQ---------LEQEDVHLNIERRLTALTG---------DAGKRLHTARSRNDQVATDIRLYLRAAIDEIIDLIYGLQYVLLDLAEQHAATIMPGFTHLQVAQPVSFGHHLLAYYEMLLRDGQRLQDCRKRVNQLPLGAAALAGTS------YPIDREQVARELGFDDI-CHNSLDAVSDRDFAIEFCASAALIMMHLSRLSEELILWMSPAFGFIR--IADRFCTGSSIMPQKKNPDVPELVRGKTGRINGHLVALLTLMKSQPLAYNKDNQEDKEPLFDTVDTLKDT-LTIYADMLAGLQVNPQAMRQAALRGYATATDLapFRDAHevAQAVRFAENKRCDLGELSLAdsAIIEQDVFEVLTLEGSlgTAPEQVRAAICRAR
     71 UniRef50_Q8E271        Argininosuccinate lyase n=1...   360     1e-97  1  15.7%  19:476   4:451     ------------------NHKLWGGRFESSLEKWVefGASISFDQKLAPYDMKASMAHVTMLGKTDIISQEEAGLIKDGLKILQDKYRAGQL---------TFSISNEDIHMNIESLLTAEIG---------EVAGKLHTARSRNDQVATDMHLYLKDKLQEMMKKLLHLRTTLVNLAENHIYTVMPGYTHLQHAQPISFGHHLMAYYNMFTRDTERLEFNMKHTNLSPLGAAALAGTT------FPIDRHMTTRLLDFE-KPYSNSLDAVSDRDFIIEFLSNASILMMHLSRFCEEIINWCSYEYQFI--TLSDTFSTGSSIMPQKKNPDMAELIRGKTGRVYGNLFSLLTVMKSLPLAYNKDLQEDKEGMFDSVETVSIAI-EIMANMLETMTVNEHImeTDFSNATELADYlvPFRKAHevGKLVLECSKNGSYLQDIPleISELIENDIYEILTAKTAvsLGGTGFDQVKKQ--
     72 UniRef50_B5YAL3        Argininosuccinate lyase n=1...   359     1e-97  1  16.3%  19:478   4:451     ------------------WGSRWRKSLEEVVEDFTYS---LYFDKRLWKVDLLGTLAHVVMLNKIGIISQEELAVLKDEIKNLYLEISNNPDLIRDS----------EDIHTFVEESLTKRIG---------DIGKKIHTGRSRNDQVILDLRLYLREETCDIAELLINLRKVLLELSEKFISTPMPGYTHLQQAQPVTLSHYFLAYDAMFSRDLQRLEDIYKRVDVLPLGSGALAGST------IPLDREYTAELLNFSKIS-DNSMDAVSDRDFVLEFLFFSALTYNHLSRLAEEIILWATKEFSFVKLP--EEYSTGSSMMPQKRNPDVAELTRGKCGKLIGNLVNMFTIMKGLPLSYNRDLQEDKPSLFSSIDEL-KIALRVWIGFLPKIEFDTERMyeDFLFATDIAEYlvPFREAHkvGEVVRFCEENNKKFRELSLEEWrlFDRDIFDLLNPEsyGSPNPVINKDVIKKRE
     73 UniRef50_Q30VF1        Aspartate ammonia-lyase, pu...   358     2e-97  1  38.6%   5:462   1:455     ----MRTEHDALGSRELPADALYGIHTLRAAENFPVSPYRLAPP--LIRALAQVKLACARTNARLGYLDNRLAEAIETACLEII-GGSHQDSFITDPFQGGAGTSANMNMNEVVANRACQLLGGVPGQHSLVSPLNHVNMHQSTNDVFPTALRVAMLHELTALEKETAALQAQLQQLEAAHQDTLRLGRTQLQDAVPMTFGMTFGAWAEAVARDRWRVFKSRERIRQVSLGGTAIGTGLGAPRDYILKAADTLRSVTGLKLSRAENLVDATQNTDQLVEVSAILKALAANLLKISTDLRLLGSGPCAGLGELKLPAMQAGSTIMPGKVNPVIAEAVSQAALRVLANDGLAAHASAMGTLELNQFMPLLAHTLLESLHLMRSSVTLLNNRCMQGLEPQAEQAQSHVGRSAALAAVLVPLAGHTAVEQMLHTARTTGTPFARVAAQALCVPEDNIRSLLAPERM----------------
     74 UniRef50_A7X0H4        Argininosuccinate lyase n=6...   358     2e-97  1  16.1%  19:472   6:435     ------------------WGGRFEVQPEEWVDDFNAS---ITFDQTLIDQDIEGSIAHATMLANQGIISQQDSEQIIQGLKSIQHDYHQDQIQ---------FSASLEDIHLNIEHELIKRIG---------DAGGKLHTGRSRNDQVATDMHLYTKKQVQDIIALIKSLQSVIVDIASNNVDTIMPGYTHLQRAQPISFAHHIMTYFWMLQRDQQRFEDSLKRIDINPLGAAALSGTT------YPIDRHETTALLNF-GSLYENSLDAVSDRDYIIETLHNISLTMVHLSRFAEEIIFWSTDEAKFI--TLSDAFSTGSSIMPQKKNPDMAELIRGKVGRTTGHLMSMLMTLKGLPLAYNKDMQEDKEGLFDAV-HTIKGSLRIFEGMIQTMTINKERlkEDFSNATELADYLvpFRTAHevGKIVLECIQQGHYLLDVPLATYQQHHSSIDA--DIYDYLQPENCLKRR------
     75 UniRef50_C9KK95        Argininosuccinate lyase n=1...   357     5e-97  1  17.3%  19:463   6:432     ------------------WGGRFSKSTDEMINEFQAS---INFDKRMYHEDIAGSIAHATMLAKCGIITDEDRDKIVAGLKDILQKIEKGNFE---------FSVDLEDIHMNIEKRLTDAIG---------EAGGRLHTARSRNDQVALDTHMYVRREIVAVQKEIENLQRALVETAEKYSDVIMPGYTHLQRAQPILFSHHLLAYFGMLSRDFARFEGVYKRADIMPLGAGALAGTT------FPIDREFVQKQLNFDSI-YTNSLDAVSDRDYIMEFLAAASILMVHLSRLSEETILWCSREFHFVE--LDDAHCTGSSMMPQKKNPDVSELVRGKTGRVIGHLMAMLTTVKGLPLAYNKDLQEDKEGIFDAID-TVKFSLAVYAQLIRGMKVRKDVMkeDFSNATDLADYLvpFRKAHAvgQAVHDCIEKGIYLEDMSLEdsPLFGADIKEAISPETCV---------------
     76 UniRef50_B8E0N3        Argininosuccinate lyase n=1...   357     5e-97  1  16.1%  19:478   4:451     ------------------WGSRWRKPLDKTVEDFTYS---LDFDKRLWKADLTGTLAHVIMLNKIGVISEEELKTLKKEIKNLYLEILNNPDLIRDS----------EDVHTFIEENLTKKIG---------DIGKKIHTGRSRNDQVVLDLRLYLKEEACNIAELLIDLRKVLFDLSEKFINVPMPGYTHLQQAQPVTLAHYFLAYDAMFSRDLERLEDIYKRIDVMPLGSGALAGSN------IPLDREYTAKLLRFSKIS-DNSMDAVSDRDFVLEFLFFSALVYTHLSRLAEEIILWSTKEFSFIRLP--EEYSTGSSMMPQKRNPDVAELTRGKTGKVIGNLVNMFTVVKGLPLSYNRDLQEDKPSLFSSVDELKIT-LKVWTGFLSHIEFNIDGMyeDFLFATDIAEYLvpFREAHkvGEIVRFCEENNKKFRDLSLEDWrlFDESVFSLLTPEsyGSPNPDINREVIKKRR
     77 UniRef50_Q51404        Fumarate hydratase class II...   356     7e-97  1  35.6%   3:463   2:454     --TDTRIERDSMGELAVPATALYGAQTQRAVNNFPVSGQR--MPQAFVRALLLAKAAAARANVSLQQLDAPMGEAIADTCLQLLQE-DFMQHFPVDVFQTGSGTSSNMNANEVVATLASRRLGGK------VNPNDHVNCGQSSNDIIPSTIHiaALEISERLLPALRHLEQTIQSKAGEVHAYVKTGRTHLMDAMPVRMSQVLGGWAQQVRQAGVHIESVLPALQQLAQGGTAVGTGINAHPRFAERFSQELNDLTGLAFRPGDDFFALIGSQDTAVAASGQLKTLAVTLMKLANDLRWMNSGPLAGLGEIELEALQPGSSIMPGKVNPVIPEATAMVAAQVIGNDAAIAVAGQSGNFELNVMLPLVADNLLHSIQLLANVSRLLADKAIASFKVNQGKLSEALARNPILVTALNPIIGYQKAAEIAKQAYREGRPIIDVALENTDLDRARLEVLLDPEKLT---------------
     78 UniRef50_Q2JXY9        Argininosuccinate lyase n=5...   355     2e-96  1  18.2%  18:478  12:462     -----------------PWSGRFAGSLHPRIARFNAS---IGFDIRLLPYDVAGSLAHVQMLGACGILSREEAEQIRQGLEQIEKEVAEGIFQP---------DPEAEDVHYAVERRLVALVG---------EVGKKLHTGRSRNDQVATDLRLYLRDEIDTIRQALWELRGVLLDLASQHVETILPGYTHLQRAQPISLAHHLLAYEEMLWRDWQRLGRVREEVNVCPLGSGALAGTS------LPIDRQLVAHLLGFERISA-NSLDAVSDRDYLVEFHAAASLILVHLSRLSEELILWATQEFGFVALT--DACATGSSLMPQKKNPDVLELVRGKTGRVFGHLQALLVTLKGLPLAYNKDLQEDKEGLFDTVD-TVKACLEAMTILleGIQFQTQRMeeDFSNATDVADYLvpFRAAHdvGQIVRTCVAEGILLKDLPLERwrAFEEDIFAAIDPRQVvgTGFAVVREALQRAQ
     79 UniRef50_A6DXB5        Fumarate hydratase n=2 Tax=...   355     3e-96  1  38.5%   5:458   3:455     ----YRTESDSLGDVQLPDDTLYGSNTARALENFAGMGLPLSAYPDFMRAMALVKRAAAMANQEVGALASDVADAIIAACDEIVA-GGHADQFPTALLEGSGGTSTNMNFNEVIANRAGQILGDKPGCYVRVNPNDHVNCSQSTNDALPTAVKLACVLTGPSITAAIEILISALRVKADETNDMLRTGRTCMQAAQPMTWGQYFLGHASALSRALTAVQSAVETLRTVPMGGTAIGTGLGAFPGYRRAIAPALSEVFGMEIRLAEDPFDAMHAADGFVRLSAELRNLSAIMAKLAADLVILGSDGASGLGELRLPPVQPGSSIMAGKVNPVIPMTVQQVWMRVHGHDAAIAIAAQSGQMEINHFEPLIALSLFEQMALITAAAQRFAARCIVGLEVDEDRSYLNLAQSFGVSTVFLKELGYTRVSAMAKRALAEGKPLADIAVEDGLLSKTDIRDVLR--------------------
     80 UniRef50_D2RIU2        Argininosuccinate lyase n=4...   354     3e-96  1  17.8%  19:478   7:463     ------------------WGGRFSKDTNALVDAFNAS---IDYDKRLYHEDIRGSIAHAHMLAKVGIISQEDAAAIEKGLKEILAEIQAGKFD---------FSTQLEDIHMNIEAALTDKIG---------DAGARLHTARSRNDQVALDMHMYMKREVTEIMDLLIAFEEALLTMAEKHLKTLMPGYTHLQRAQPITFAHHMLAYFNMLRRDFRRLQGVWDGADIMPLGAGAVAGTT------LPIDRFQVAEELHFS-QVYGNSMDAVSDRDYVLEFLSFASLLMMHLSRLSEEMCLWSSTEFGFIE--LDDAFATGSSMMPQKKNPDISELVRGKTGRVYGHLTALLTTLKGLPLAYNKDLQEDKEGFFDAID-TVKFSLQVYRDMILSTKVNKERMAEAvsNATDLADYLvpFRKAHavGKAVAKAIAEHKLLGQLTLEesPLFEKDLLECLKPENCvgPAPqgKEAVEEQKK
     81 UniRef50_A4XKG3        Argininosuccinate lyase n=4...   354     4e-96  1  17.8%  19:472   7:436     ------------------WQGRFSKDTARIFDEFNAS---IMVDINLFEYDVMGSVAHVKMLSKCDIIPEDEGKLIVNTLYEILNDFKEGKIE---------FDMSDEDVHMLIEKELIKRIGQV---------GKKVHTARSRNDQVVLDERLFCREKNLYLQELIKNLIDTIIKLAEENIDTIMPGFTHLQKAQPVLFSHYILAYAQMLKRDLLRFRQNFISINLNPLGSAALAGTT------FDIDRFFVADQLEFDGV-TENSIDTVSDRDFILEMLFNIAMLQMHLSRLAEDFIIFNTDEFRFIE--LDDAFCSGSSIMPQKKNPDALELIRGKTGRTFGNLIGLLTVLKALPLSYNKDMQEDKEFLFDSIDTAEKS-LIIVNEILKTLKVNKENMLLACKSGFINATDLAdfRDAhvVGNIVKYCIENNKSLEELSTEEFKRFCDKIEE--DVFKFISLENCIKRR------
     82 UniRef50_A0LEB1        Argininosuccinate lyase n=1...   353     6e-96  1  19.1%  19:473   6:436     ------------------WQGRFDQPTNRQVEDYTAS---IHFDNRLYRYDIEGSIAHCRMLAQCKIISHDDASLIVQGLGEIRRELERGKL---------HLGSSNEDIHMAIEQELMRKIG---------EVGGKLHTARSRNDQVALDVRLYMRDTLLQCRGLILQTQKVLVSCAEENLGVVMPGFTHLQHAQPILLSHHLMAYYEMLKRDDERFEQCFHRTNVLPLGSAALAGTT------FPIDMEWTAKYLNFPRV-TSNSIDAVSDRDYLIEFGAASAMLMMHVSRLAEELILWSSTEFDFIE--ISDAFCTGSSIMPQKKNPDVPELMRGKTGRVYGNLMALLTLTKALPLAYNRDLQEDKEPVFDTADTII-STLRLLSRLIPEIRFHRERMGEMAIQGFTLATDlvPFraHHIVGQIVQYCLKNRKQLHDCTVEELKTFHKTIDQ--DVFPFLEVAGAIDQRV-----
     83 UniRef50_A9KQ51        Argininosuccinate lyase n=4...   352     1e-95  1  15.2%  19:478   4:449     ------------------WGGRFTKETNQLVHNFNAS---ISFDQKFYVQDIRGSIAHVTMLAKQGILNDEEKNKIIDGLNGIRDDIESGSLVI---------DSTYEDIHSFVEAHLISRIE---------EIGKKLHTGRSRNDQVALDMKLYTRDEITVLDELLRDLLFELYSLMKEHTETYMPGFTHLQKAQPITLSHHMSAYFEMFRRDRDRLSDIFKRMNTCPLGAGALAGTT------YPLDRAYTASLLSFT-EPTRNSMDSVSDRDYLIELLSALSTIMMHLSRFSEEIIIWNTNEYRFVE--IDDAYSTGSSIMPQKKNPDIAELVRGKTGRVYGALMSLLTTMKGLPLAYNKDMQEDKELTFDAID-TVKGCLSLFTGMIRTMKFNRDTMKASatNATDAADYlvAFRDAhiIGHLVLTCIEKNCSIEDLSlaISPVFKEDIYDAISLKTCVeiGGPGVDAMNEVIK
     84 UniRef50_O27580        Adenylosuccinate lyase n=14...   352     2e-95  1  20.0%  18:478   5:446     -----------------PVEFRYGTPEMR----------VIWEAENKLQKMLDVEAALAQAEGELGIIPAEAASEIVRKA--------------------STEFVTLERVNEIERDTKHDilVKALAEQCEGDAGEYVHFGATSNDIVDTSNSLLLRDSISVLRDKLTRVLEVLLALADENRDRVCIGRTHGQHALPTTYGMKFAIWADEIHRQLERLDACSERLCV-GMMTGAVGTTAALGEEGLE-VHERVSEILGLRPVLISNQVVQ---RDNHAEFIMVLANIATTLDKIALEIRNLQRTEIMEVGEKFDPEKQVGSSTMPHKMNPITAERICGIA-RVIRSYVVAALENNPLWHERDLTNSSSERIILPEACILTDYILKLTLDVLCNLVFYPENIKRNLEFTGGLIMAerRGMGRQTAYAAVreASRTGRSLRDVVLERsyLTVEDLEEIMNPETYIGSARRMVERVLEESQ
     85 UniRef50_Q1Q5N1        Strongly similar to arginin...   352     2e-95  1  18.2%  19:475   6:451     ------------------WGGRFTEQTKASVESFTES---ISFDWRLYKFDIEGSIAHATMLAQRKIITEKEKKEIIKGLEIILAEMNAGTF---------KFKKNLEDIHMNIESALIERIG---------EPAKKLHTARSRNDQVALDLRLWVREQILITSNYLTLVQQGLVKKGKEYFGAIMPGFTHMQHAQPILLSHYLLAYVEMFERDEKRLADCAKRLNESPLGACALAGTT------LPTDPMITAKLLNFGSI-CQNSIDAVSDRDFCMEYVFALSLISMHLSRLCEEWIIWCNDEFSFID--ISDAYCTGSSIMPQKKNPDVLELIRGKCGRVYSHLTTLLTLFKGLPLSYNRDMQEDKVAVFDAAE-TVHSMLNIFAELIANTRFNSERMKLACENGFSDATAlvPFRKAHevGNIVRECVRLNRKIKDLDLehSHLIKKDVFQVIGVENCvsSAPRLVKNRLA---
     86 UniRef50_B3QN90        Argininosuccinate lyase n=3...   351     2e-95  1  19.5%   9:455   2:426     --------SDQSKQKELLWQSRFSEPFDREALQFSSS---VHVDGLLYREDIQGSIAHATMLGEEGIISAGESEQIVEGLKAVEKEIESGELVPVW---------EDEDIHTVIENRLKELIG---------PAAGKLHSGRSRNDQVATDTRLYLRRNIDRLVGLLEAMQSTLLDKAERYKSTIMFGYTHLQRAQPMSAGHYYMAWHSMFGRDAERLADLRKRANISPLGAAAFAGST------LPLNPARSAELLEFDGVFA-NSIDAVSDRDLVIEFVSACSMIMMHLSRFSEDVILWTSAEFNYLS--ISDAFATGSSIMPQKKNADIAELVRGKTGRVYGNLMNLLTIMKGLPLSYNRDMQEDKPPLFDTAE-TTASSLSVFRRMIEKTWLNEERlaEDLSLATEIAEYLvpFRDAHRigKIVAYAIEKSKTLPTISLDEYRTFSESFDE-----------------------
     87 UniRef50_B9MRP4        Argininosuccinate lyase n=4...   350     8e-95  1  16.3%  19:472   7:436     ------------------WEGRFSKSTAQIFDLFNAS---IMTDIKLFEYDILGSVAHVKMLAKCNIIREDEAKLIIDSLYQILEDFKLGKI---------VFGISDEDVHMLIEKELIKRIG---------EVGKKVHTARSRNDQVALDERLFCREKNLYLQELIKTLINTITTLAEENIDVIMPGFTHLQKAQPILFSHYILAYAQMLKRDLLRLRHNYSMTNSSPLGSAALAGTT------FEIDRFFVASELGFESV-TENSVDTVSDRDFILEMLFSLAMIQMHLSRLAEDFIIFNTDEFKFIE--LDDSFCSGSSIMPQKKNPDALELIRGKTGRVYADLIGLLTVLKGLPLSYNKDLQEDKEFLFDSIE-TVEMSLIVINEILKTLKIDKENmkSGFINATDLADYlvPFRDAhiVGNIVKYCIESDKTLEDLSLEEYKRFCEKIQE--DVYQFIKIETCVNRR------
     88 UniRef50_C0EVA8        Putative uncharacterized pr...   350     9e-95  1  39.9%   5:430   1:450     ----MRLEKDTLGEKYLTDETVYGINTQRAVENFPLSHKKVNLH--LIHAMLLVKKAAAKTYENleDIEKEKYQAIVAACDELLLKTEEdaLFVTQALQGGAGTSTNMNVNEVIANIALKHLGKNYGDYNCIHPLDDVNRGQSTNDVYPTALRIASIFLIRKLSDACAALQTSLQEKENAFQDIEKLGRTEWMDAVPITLGEEFGACAQAIARDRWRIYKVEERLRQVNLGGTAVGLSDNAQHKYRFRVIEELRRLTGLGLAAAEYPMDLTQNNDVFVEVSGLLKALAVNLMKIANDFRIMNSGPGGGIGELHLKAMQQGSTIMPGKVNPVIPEMTMQCAMRIIANDTAITMAAAHGEFELNAFLPLIADSLLESLELAERAVTIFREKCVETIEPDVENCKKHLEQSYAFATAYTPKLGYETVAKIIKE------------------------------------------------
     89 UniRef50_A4W487        Argininosuccinate lyase n=2...   348     3e-94  1  18.6%  19:458   3:428     ------------------AKKLWGGRFEASLEEWVefGASIRFDQKLAKYDIQGSLAHVKMLGQTRIISQAEAQVIQAGLEELLEEYEAGKL---------VFDIRNEDIHMNIESLLTEKIG---------SVAGKLHTARSRNDQVATDMHLYLKDTLFQVVDKLTNLRQILVDLAQEHVETIMPGYTHLQHAQPISFAQHLLAYYNMFSRDSERFAFNMQHTNVSPLGAAALAGTT------FPIDRQMTSDLMGFA-KPYSNSLDAVSDRDFILEFLSNASILMMHMSRLCEEIINWCSYEYQFV--TLSDTFSTGSSIMPQKKNPDMAELIRGKTGRVYGNLVGLLTVMKSLPLTYNKDLQEDKEGMFDTAETVLISI-DILAGMLKTMTVHKERmeKDFSNATELADYLapFRQAHevGKLVLECSKAGHYLQDVsqAISPLIQADIYDALS--------------------
     90 UniRef50_B2A8E3        Argininosuccinate lyase n=1...   348     3e-94  1  16.9%  19:457   5:421     ------------------WGGRFSKQTDQLVDEFNAS---IEFDNRLIFYDLLGSQAHVKMLFQQGIIDTTDYKQITEGLDIIWKEAEQDKLE---------FNLSDEDIHMSIEKRLIELKG---------EVGKKLHTARSRNDQVAVDMNMFLCDKAIKLVNELLQNMSVIKELSEQHTKTYMPGYTHLQRAQPTTLGHHMLNYFWKFQRDASRLIDFRNRADLSPLGSGAFAGT------GFNISRRSTRKDLGFT-QQFENSMDAVSSRDLSLEFIFCLSSIMINLSRLAEELILWSTKEFDFIE--LDDAFATGSSIMPQKKNPDVPELIRGKTGRVVGHLTALATTYKGLPMAYNKDFQEDKEGLFDSLD-TVESSLKLTSKILSTMTIKTKNMEKAlsNATDIADYLapFRDAHavGQLVKHCQEHNKLFYQLTEQELDISFKQIADSL---------------------
     91 UniRef50_Q3SM68        Argininosuccinate lyase n=1...   345     2e-93  1  16.6%  19:469  12:451     ------------------WSGRFSEPVSEIVKRYTAS---IPFDYRLAEFDIQGSLAHAAMLHHVGVLSADDLAAIRGGMGELLEEIRAGRFAW---------SLDKEDVHLNIEAALTAKIG---------DAGKRLHTGRSRNDQVATDIRLYLRDAIDRILAGLKACQTSLVDLAEAHADTVMPGFTHLQVAQPVTFGHHLLAYFEMLARDAERMADCRRRVNRLPLGAAALAGTS------YPIDRAYVARELGFEAV-CENSLDAVSDRDFAIEFAAAAALVMTHLSRLSEELILWMSPRFGFID--LADRFCTGSSIMPQKKNPDVPELVRGKTGRVNGHLVALLTLMKGQPLAYNKDNQEDKEPLFDTVDTLADT-LAIYADMLRGVTVKPDAMHAAVMQGFATATDLapFRDAHevARAVRVADESGRDLADLPLDesPIIGDDVYALLTLEGSlgTAPAQ---------
     92 UniRef50_B4H329        GL13348 n=4 Tax=cellular or...   345     2e-93  1  40.1%   2:363 149:511     -EGKFRMEKDTFGELKVPAEMLFGAQTMRSKINFPIGDIGERMPMPVIQAMGILKKACAEVNKDYG-LDGKISDAVSCACDDVIskFYKRGHFPLVIWQTGSGTQTNMNTNEVISNAAIKAMGGELGSKKPVHPNDHVNKSQSSNDTFPAAIHISVGMEleRLIPSLTHLRDALKCKSEDFKDIIKIGRTHLMDAVPLTLGQEFSGYAQQLSYGLDRINGCLPRVYELALGGTAVGTGLNTHKGFAEKVSKRIADLTCLPFVKAPNFFEALGARDAMVEVHGVLNTIAVSLMKIANDIRLLGSGPRCGLGELMLPENEPGSSIMPGKVNPTQCESITMICAQVMGNQVAVSIGGATGHFELNV-------------------------------------------------------------------------------------------------------------------
     93 UniRef50_B8FH31        Argininosuccinate lyase n=8...   343     1e-92  1  18.8%  18:469   6:439     -----------------PWDGRFAEKTDDMVEAFTSS---IQVDKRLYAHDITGSIAHARTLAEAGVITSDEADAMEKGLRQVKGEIEAGNFKYDDSL---------EDIHMHIESRLTEILG---------PTAAKLHTGRSRNDQIALDNRLYLRDETRRIIAMLHELRQAIVDSAQAHLDYFVPGYTHLQRAQPVLLSHHLMAYYEMFTRDSDRFTDALYRINVMPLGSAALAGTT------FPLDREYTASLLGFEGV-TQNSMDAVSDRDFIMEFLSDASICMVHLSRMSEELVLWSSSEFAFLNMP--DAFATGSSIMPQKKNPDVPELVRGKTGRVVGSLMAILTTMKSLPMAYNRDMQEDKPPLFDAVDTL-KACVAMFARMVPKLEFNRRNmnQGFLNATDMADYlvPFREAhiVGRAVAYALDRGRELHEISLNDLRKfeKDLYEALTVEHVVERRRTI---------
     94 UniRef50_Q0TTA6        Argininosuccinate lyase n=6...   342     2e-92  1  18.0%  21:454   2:417     --------------------KLWGGRFTHQVDDlnTFNSSISFDSRMYKEDIIGSIAHVTMLGEEKIIPKEDSKKIASGLYEILNKLNQGVLKI---------DNSSEDIHSFIESTLTDYIG---------EEGKKLHTGRSRNDQVTLDTKLYLKGYIKILICEILNLEKTLLNLSSENKETIMPGYTHMQKAQPITFAHHILAYSEMFKRDISRLLDCYKRLDEMPLGSGALATTT------YPINREKVANLLGFSKVTL-NSLDSVSDRDYAIETLSCLSLLMMHLSRFSEEIIIWSTDEFKFIE--LDDSYSTGSSIMPQKKNPDVAELVRGKTGRVYGDLMTLLTVMKGLPLAYNKDMQEDKEALFDGLDTTLLSIKTF-NGMIKTMKINKSIMKTSAsnATDVADYLVkfRDAHevGNLILYCIDEGKSIDNLSLSEFKTFSNKFE------------------------
     95 UniRef50_Q9LEU8        Argininosuccinate lyase (At...   340     6e-92  1  18.9%  10:463  51:487     ---------DDTASKEV---KLWGGRFEESveKVEKFTESISFDKVLYKQDIMGSKAHASMLAHQGLITDSDKDSILRGLDDIERQIEANKFEWRTDR---------EDVHMNIEAALTDLIG---------EPAKKLHTARSRNDQVATDFRLWCRDAIDTIIVKIRNLQRALVELALKNEALIVPGYTHLQRAQPVLLPHVLLTFVEQLERDAGRYVDCRARLNFSPLGACALAGT------GLPIDRFMTANALGFT-EPMRNSIDAVSDRDFVLEFLYTNANTGIHLSRLGEEWVLWASEEFGFM--TPSDSVSTGSSIMPQKKNPDPMELVRGKSARVIGDLVTVLTLCKGLPLAYNRDFQEDKEPMFDSTKTIM-GMIDVSAEFAQNVTFNEDRIKKSllDATTLADYLvpFrsHDIVGKLVGVCVSKGCELQNLSLEesPVFEEDVFGFLGVENSV---------------
     96 UniRef50_C1TNB5        Argininosuccinate lyase n=1...   340     7e-92  1  17.8%  19:478   2:450     ------------------WKGRFSQETDRKVQAFSQS---LDLDWRLARWDIRGSLAHAEMLAKQDLISQEELEAIRSGFQEIMDEIERGDFIPDESL---------EDVHMNLEHRLTEKIG---------DAGARLHTGRSRNDQVGTTMRLYVKDVLCQVKSGMIDLMDALLNRAESHRETIVPGYTHLQQAQPVSMGHLWMAYFQSFSRDLKRLEFAMDEADECPLGCGALAGST------LPLDREYTAEALGFS-RLCENSMDGVGQRDYIFDALSFSTMFAVHCSRMAEDLIIYSSAEFGWLKLP--DAFCTGSSMMPQKKNPDVLELVRGRTGQMIGHLVDILATLKGLPMTYDRDLQEDKRGLFSSFDVLSH-VLGVLPSLVRAIEVDADRAAESFADGLALATDvvPFraHHRVGSLVGWCVREERSLFDLTLEDFEDfdENLLSLVDLEAAvgTGFRQVSRQIERGR
     97 UniRef50_Q7MH73        Probable acetyltransferase ...   340     9e-92  1  17.3%  21:477   2:452     --------------------ALWGGrtQAADTRFKDFNDSLRFDYRLAEQDIVGSIAWSKALLSVNVLSKEEQQKLEFALNELKLEVMEDPHQILHSDA--------EDIHSWVEQQLIGKVG---------DLGKKLHTGRSRNDQVATDLKLWCRQQGHQLLLGLDKLQTQMVNVAKQHQATVLPGYTHLQRAQPVTFAHWCLAYVEMFERDYSRLSDALTRLDTCPLGSGALAGTA------YPIDREQLAQDLGFR-RATRNSLDSVSDRDHVMELMSVASISMLHLSRLAEDMIFYNSGESGFIE--LADTVTSGSSLMPQKKNPDALELIRGKTGRVYGSLAGMMMTVKALPLAYNKDMQEDKEGLFDALDTWNDCM-EMAALCFDGIKVNGERTLEAaaNSTELADYLvpFREAHhvGVAVVGAIAQGCALEELSLEqsPVIEADVYQILTIESClgVSPKQVAYAVEQA-
     98 UniRef50_UPI0001C4209A argininosuccinate lyase Arg...   337     5e-91  1  19.5%  36:471  18:453     -----------------------------------VYTSSLEFDRFIFDADIRCNYAHTSMLKAQGIIDSEIADKILDALDKLSEEGFDALEFDHSV----------EDVHMAVENYVTKLVG---------PEAGFMHTAKSRNDQVATDIRLLLRDRISEIQIAILEFIEGILELAKEHKETVMIGYTHLQHAQPITLAHHLMAHAQALKRDYQRLDDTYKRVNLNPLGSAAMATTS------FPIDRELTTRLLGFD-DYLENSMDGVSSRDHIAEAVFDLTALCTTLSKICEELVLWSTYEFGIVS--MADEYSSTSSIMPQKKNPDVAEVARSKCAIVNGELMTILTILKAIPYTYNRDLQEITPHLWNACDVAYDT-LKITNHMLLTVTFNTERCLELAGANFATATDLapFRTAHkvGRIVNEAVAEGLNPSevADELGflDDDLIHNALNPIENvgPSPEMVQ-------
     99 UniRef50_P73257        Argininosuccinate lyase n=2...   336     8e-91  1  16.7%  19:478   6:455     ------------------WSDRFEGTLHPAIALFNAS---IGFDIELIEYDLDGSIAHGKMLAKTGIISPGEAEQLVQGLEQIRQEYRAGNFNPG---------VDQEDVHFAVERRLTELVG---------DVGKKLHTARSRNDQVGTDVRLYLRAQIDDIRQRLRDFQAVLLQLAETNVETLIPGYTHLQRAQPVSLAHHLLAYFQMAQRDWQRLGEIRARTNVSPLGSGALAGTT------FPIDRHYSAELLGFAGV-YANSLDGVSDRDFAIEFLNAASLIMVHLSRLSEEMILWASQEFSFISLT--DSCATGSSIMPQKKNPDVPELIRGKAGRVMGHLQGMLVLMKGLPLAYNKDLQEDKEALFDAVKTVQVSLEAMTILLDEGIVFRQERLAEAvsNATDVADYlvPFREAYnvGKVVKTSLAAGKLLKDLTLAEwpAFEEDIYQAITPQQVvgTGFEQVKMAIANAK
    100 UniRef50_B1GYN4        Argininosuccinate lyase n=1...   336     9e-91  1  14.5%  31:478   1:442     ------------------------------MQNFDQFIGSFSFDNRLAEVDIAGSIAHTKMLIKTKIISASDGRKIVSGLTSILKDIGKGWKFPEE-----------EDIHYAVERELIRRIG---------PVGGKMHTARSRNDQVVADLRIYLKQEIGIVENLINNFQKVLVEKAGENIDVVMPGFTHLQPAQPVLAAHHLLAYAWMMQRDRERLADCYKRTDVLPLGSAALAGTS------FNIDRQYTAKLLDFENIS-ENSLDAVSDRDFAAEFVFCVSLTALHLTRFCEEMILWMNPEFGYI--TIDDKFTSGSSIMPQKRNPDCAEVIRGKSGRIFGDLIALLTIIKSLPLAYNRDLQEDKPPVFDALDN-IKMCLEVISEMTESLEFVGERALKSTEKGFIAATEivPFRAAhiVKDIVLYCRKNSKTLNELSIEesKIFKKDIFKYLDAKnyGGTSerQIDNIKQKLK
    101 UniRef50_B4U6T9        Argininosuccinate lyase n=3...   336     9e-91  1  16.7%  19:455   5:415     ------------------WSGRFKEDTSKDVELFTES---ISFDKALAMYDLEQDFAHLEALLKAGVISKDSYENIKSGLKKIKQEIEKNEFY---------FDISKEDIHMNIESRLYELIG---------EDAKKLHTGRSRNDQVNTDLRLYLKDHILKIFELLKALKQQLVLKAKEYEDLIMPGYTHLQRAQPVLVAHYLLSFKEAFLRDSQRLIDAYRRIDTLTLGSGALAG------ADFPLDRFLEASILNFSKIS-RNSMDAVADRDFAIEYMFCLSSIAMHLSRMAEDFIIFNTEEFKFIDLP--DSLCTGSSIMPQKKNPDVLELIRGKAGRVYANLINLMVNLKGLPMTYNRDLQEDKEPIFDATNTILNS-LKMMILIIKDIRFRQNIEAGNLLLATDLANYLvpFREAHhvGNIVAYAIENQKPLESLTKEELNNFSKAFDK-----------------------
    102 UniRef50_C0GQD4        Argininosuccinate lyase n=1...   336     1e-90  1  18.1%  14:478   5:455     -------------EKQKLWGGRFTSATSSLVEDFTQS---LDFDRFLALHDLEGSRAHARMLAHAGIISEDELQQILSGLDRIENELEQDEFTW---------DPGLEDVHMNIEKRLTDLIGA---------PGQKLHTGRSRNDQVALDFRLYTAAALQEWQQVLKELIQALTRQAQAHRDTLIPGYTHLQPAQPVCLAQHLLAYARMFMRDHERIEDALPRVKVSPLGAAALAGTT------YPLQPEQVAEHVGFEYVF-KNSMDAVSDRDFVLEGLFIASMIMMHLSRLGEEIILWSNPGFGFIILP--DAYSTGSSIMPQKKNPDVAELVRGKTGGVYGRLMALLTTMKALPLTYNRDMQEDKEPFI-EAHRSVSSSLRVMAGMIAQTEFDRERMFGAllNATELADYLvpFRQAHHigRLVAFAEEKGLGLEDIDLDtsEIVDSDVYHVLDYQQavTPGGTGPDSVDEQIR
    103 UniRef50_Q2GFQ7        Argininosuccinate lyase n=6...   336     1e-90  1  17.7%  22:478   5:455     ---------------------LWGGRFTVSPSDikKINESISFDKILYEEDISGSIAHCKMLVNQKIISKYEGQLIIHGLEVIQNQISSGTFE---------FSTDLEDIHMNIEHHLKKMIG---------NIAGKLHTARSRNDQVATDFKLWIRKSIVKLETLLHELQQTILNIAEANYDTIMPGFTHLQIAQPVTLGHHLMAYFEMLKRDCSRWQDLHKRMNQCPAGSAALAGTS------FPIDRHFIAQELKFDS-PTENSIDAVSDRDYVIEFLSNASICIMHLSRLAEEIILWCSYNFKFI--TLSDNITTGSSIMPQKKNPDAAELIRGKTGRIFASLNQILVVMKGLPLAYSKDMQEDKEPVFDAANNLML-CIEAMNSMLNNITINKSNMLKAAEHDYSTATDLADWlsHETTGQIVKLAEQNHCKLHELTLEqpSIT-EDVFSILSVKnyGGTAPANVIEAIKRGK
    104 UniRef50_P24058        Argininosuccinate lyase n=4...   332     2e-89  1  17.2%  19:478  11:455     ------------------WGGRFSGSTDPIMEKLNSS---IAYDQRLSEVDIQGSMAYAKALEKAGILTKTELEKILSGLEKISEEWSKGVFVV---------KQSDEDIHTANERRLKELIG---------DIAGKLHTGRSRNDQVVTDLKLFMKNSLSIISTHLLQLIKTLVERAAIEIDVILPGYTHLQKAQPIRWSQFLLSHAVALTRDSERLGEVKKRINVLPLGSGALAG------NPLDIDREMLRSELEFASISL-NSMDAISERDFVVEFLSFATLLMIHLSKMAEDLIIYSTSEFGFL--TLSDAFSTGSSLMPQKKNPDSLELIRSKAGRVFGRLASILMVLKGLPSTYNKDLQEDKEAVFDVVDTLT-AVLQVATGVISTLQISKENMEKAlmLATDLALYlvPFRQAHTagKAVHLAETKGITINKLSLEdkSISPqdVSQVFnvEQYTALAGTAKSSVTTQIE
    105 UniRef50_A7HJN0        Fumarate lyase n=4 Tax=Ther...   331     3e-89  1  38.9%   4:466   2:457     ---NCRTEKDYLGECLIPEDAYYGVTTQRALELFPSTGEIL--DDKFIWAYFMIKKSAAILNSQLGYLDNQIAQAIQKACDEWE---KLKSYIVVDPLSGGAGTSVNLNINEVIANRATELLGGKKGEY-IVNPYNHVNLHQSTNDTFVTAGKIAVIVRLRELVEAVIKLQEKIQEKEKEFYSIRTIARTQLMDGVPILMGQQFGAWADALARDRWRLNKVEERIRSVNIGGTAIGTGIGAPKEYVLKIVDVLRQVTNVKIAKSENLIDATQNLDVFVEIHGLIKALGVNLFKISNDIRLLGSGPNAAIGELELPKVQIGSSIMPGKVNPVIPEYVMQLVLAVFGHDEAISHATAQGNLQLNQFAPLIVHYTLKSMQFLSKACNSLSDY-IAQIKVKEEKCKEHLKKSTANLTPLINYFGYERVAEKI---VETNWDIeeLLAKEEGISSQELVKKLNIDKMTGLG------------
    106 UniRef50_A1TNJ5        Argininosuccinate lyase n=5...   331     3e-89  1  17.0%   9:478  11:481     --------QDQLATKAQAWSALFSEPMSDLVKRYTSS---VFFDKRLWQADIAGSLAHADMLAAQGIISADDHAAIRRGMATITQEIESGAFEW---------KLDLEDVHLNIEARLTQLVG---------DAGKRLHTGRSRNDQVATDVRLWLRGEIDMIADLLKELQRSLVDVAEQNVEVILPGFTHLQVAQPVSFAHHMLAYVEMFARDAERMQDVRRRTNVLPLGSAALAGTT------YPLDRERVARTLGMEGV-CQNSLDAVSDRDFAIEFTAAASLCMVHVSRLSEELIIWMSQNFGFIR--IADRFTTGSSIMPQKKNPDVPELARGKTGRVVGHLMGLITLMKGQPLAYNKDNQEDKEPLFDTVDTLKDT-LRIFAEMvgGITVNPQAMEQAAQKGYATATDLapFRDAHevAHAVKAATSHGVDLSELPLthPAIGKDVFDAllNARNTlgTAPAQVRTQLARHR
    107 UniRef50_B7GJB1        Aspartate ammonia-lyase n=1...   331     4e-89  1  36.6%   6:434   5:432     -----RIEEDFIGKMEIPADALYGIHTARTVQNISFSGKKLFQYPEYIHALAFVKKAAALANVEAGLLSVAIKEAIVWACDEIL-DNRYHESFVIDVLHGGGGIGTNMNMNEVIANLANEKLGGRRGTYHPVHHTEHVNRSQSTSDVCHTANRIAVILSFQSLGKQLEMCIQVMNELSKKFNHVETMSRTCLQDAMKVRVGESFRSYAAMLKRRLHWLSVSVNCLYQINLGGTVIGSGVGAPQHYRDVVVQKLCEVSNLPLQHRENLFDAAQHIDDLAAVSKELHLLASCLIKVAKDLRLRSSGPEGGFGEIVLPAVQAGSSFFPGKINPIVPETMIQCCFQVLGCDRVVQATLEHGELDLNVFEGIACINILDAMKMLERALASFIENCLLGIEVNEQRCKQLANSLIPAIVELKEKFGYSTVARWMKEKSRE--------------------------------------------
    108 UniRef50_O66856        Adenylosuccinate lyase n=36...   331     4e-89  1  18.7%  41:463  13:421     ----------------------------------------VWSEVNKFKKWLDVEIAVCRAWAKLGKIPRDALKKIEEKT------------YVDKKVVEKIKEKEKVFKHDVLAFV-------SVIAEQVGEEGRYIHMGLTSSDVVDTALALLIREAIDIILKDIDKVMEEIKRLAFEHKDTLMMGRTHGVHAEPYTFGLKMCVWYDEMRRQKERLLFARENVLYGKI-SGAVGTYSNIPPE----VEKLALEELGLKIEPASTQIV---HRDRHAQLLTTLGLIASSLEKFATEIRHLQRTEVLEVLE-PFTKGQRGSSAMPHKKNPIHSERICGLA-RVIRANSIPAMEDVVLWHERDISHSSVERVILPDSFIALDYILNLFYEILKGLVVNKERMRKNMELSKGLYAslSRDYAYDIVQRCAMKAWESDKTFKETLLEDpyLTEEEIEKALDPWEFL---------------
    109 UniRef50_B4HEE0        GM24753 n=6 Tax=cellular or...   330     6e-89  1  29.2%   4:466   8:410     ---ETRQESDTLGPMEVPMDRYYGAQTMRCLINFRIGGEEERMPRQIIQAMGMLKKAAAETNQEFG-LDPKLSTAISNAADDVIS-------------------------------------GKLYDEGHFPLPIWQTGSGTQSN----------------------MNSNEVIGNRAIE----LLGGRIGTKDPvpTTIAANAApyAQKLTNGLQRIDAVLPRVYQLALGGTAVGTGLNTRRGFAEKCVKRIAQLSGLPFVVAPNFFEALACRDAMVEVHGALNVLAVSLMKVTNDIRFLGSGPRCGLGELFLPENEPGSSIMPGKVNPTQCEAMTMICAQVMGNHVAVSVGGANGHFELNVFKPLIASNVLRSIKLLADGCISFNCNCVKGIKPNKEKLAKIVNESLMLVTALNPHIGYDKSAQIAKAAHKNGTTLKVEALNAG-ISEKDFNEWVRPEKMLGPS------------
    110 UniRef50_A9V8F9        Predicted protein n=1 Tax=M...   330     9e-89  1  17.5%  21:478  22:494     --------------------KLWGGRFTGAVdlMEEFNASINVDRRMYRQDIVGSQAYARAIAKVGLITEDERDALITGLDQVLAEWANNQF---------VLQPNDEDIHTANERRLKELAG---------PVAGKLHTGRSRNDQVATDMRLWLRDELTELIDLLKAFVASSIERAAADIDVLMPGYTHLQaaQPIRWSHWVLSHAWAMQRDIERLTDLRKRVNVMPLGSGALAG------HPFGIDRQALAQDLGFDAISF-NSLDATSGRDFVAEFLFAATMVNIHLSKWAEDLCNYSSKEFGFV--QLSDAYSTGSSLMPQKKNPDSLELIRGKAGTTFGSCAGFLMTLKGLPSTYNKDLQEDKSAMfpAVVSLTRSCVQIATGVLSTLRINPEQMRAALslATDLAYYlvPFREAhlSGQCVARAEEKKCSLNELTLEDFQAIHPKFEADvsVDQYSASGGTGRTAVLEQIE
    111 UniRef50_B2S8N8        Argininosuccinate lyase n=4...   329     1e-88  1  17.1%  23:472  11:454     ----------------------WGGRFASGPDAIMEenASIGFDRKLYAQDIQGSLAHAAMLAKTGIIAAEDHKQIENGLKTIRKEIEEGKF---------TFSRKLEDIHMNIEARLAELIG---------PAAGRLHTARSRNDQVAVDFRLWVKQELEKTAAALKNLIEAFLERAEEHAATVMPGFTHLQTAQPVTFGHHCMAYVEMFGRDLSRVRDAIERIDESPLGAAALAGT------GFPIDRHMTAKALGFR-EPTRNSLDSVSDRDYALEFLSLAAICAGHLSRLAEEIVIWSTPQFNFVR--LSDAFSTGSSIMPQKKNPDAAELVRAKTGRINGSLVALLTIMKGLPLAYSKDMQEDKEQVFDAAENLELAIAA-MAGMVRDLTVNVAAMKKAAGSGYSTATDLapFREAHHvgRAVALAESRKVDLAKLSLEElpAITAEVFGYLTVEKSvgTAPQEVRR------
    112 UniRef50_B6WBB2        Putative uncharacterized pr...   329     1e-88  1  36.5%   4:403   2:392     ---KFRQEEDSLGIVNVPADHFWGAQTERSLENFPQEVEK--MPHSQIMAIASIKRCAAIVNNREEKLDDKKKDLIVDACDRILK-GEFDEEFPLTVWQTGSGTQTNMNVNEVISHIANE-------NEKIIHPNDHVNMSQSSNDVFPTAMHLStkNLSDKLLKELPKTIEAIKKLEEDNKDIIKTGRTHLQDATPVKLSQEISAWRTCLERDLKVLEEVKEELTYLAIGGTAVGTGINAEKEFGDEMAKELSELYEFEFKSDENKFYQLSSKSALVNVHGTIKALATDLYKIANDIRFLSCGPRCGISELTIPANEPGSSIMPGKVNPTQVESITMICIKIMANDFAISMANTQGQLQLNAYMPLIIHSMDNSITLLSKSLKCFREKLLEGLVANEKNIEK---------------------------------------------------------------------------
    113 UniRef50_B3T9V2        Putative Lyase n=1 Tax=uncu...   328     2e-88  1  19.7%  23:473   8:434     ----------------------YTTHTFQSASHYTVS---VGYDRRLASYDIRASVAHAQMLARQEIIPQSDSDAIVRGLGEVHQEMEDGTFPWRDEL---------EDVHMNIERRLHELIG---------EPAARLPTARSRNDQVATATRLYVRDAIEATMARVHRLQGTLLDLAEAHATVLMPGYTHLQRAQPVLLAHHLLAYVEMLERDTGRLADCLSRANVLPLGSGALAG------VPYAIDREFLARELGFETVSA-NSMDAVSDRDYLVELLASASICMMHCSRMAEELVLWSSQEFGFIR--LGDEWITGSSMMPQKRNPDFAELARGKTGRVYGHLVGLLTVLKGLPLSYNRDLQEDKEALFDTVETL-DATLEVFAGMLGSVEVNAERMRSAAEDGSLLATDlvPFRTAHAAVrlCELAAQDGRPLQELTLEEYRRFSPAFDA--DVFQLTALTSVAARAV-----
    114 UniRef50_B8DQ99        Fumarate hydratase, class I...   328     3e-88  1  37.0%   6:462  44:519     -----RLERDSMGLVEVEQGRLWGAQTQRSLDNFRIGTDR--MPLAVVHALARIKKAAALVNRDLGLLPPPpaEAIARAADEVLA-GQHDDHFPLSVWQTGSGTQTNMNVNEVLANRATQLlgGHPHIHPPIHPNDHVNRCQSSNDAFPAAMHLAAALALRDDlpGVRHLRDALRAKAAACADIVKIGRTHLQDAVPLTLGDEMSGWAAQLDACLEGLDAAMPHLCRLALGGTAVGTGLNAHPAFAPRAIALLADMTGLPLVPAPNPFAALAAHDGLVLTSGALRALATALLKIANDVRWLASGPRCGIGELRLPENEPGSSIMPGKVNPTQCEALTMVAVQVMGLDVAVGMAGSQGNFELNVFKPLIIHNVLTSMRLLADGCRSFADHAVAGMQPDRAGIAAHVGRSLMLVTALAPVVGYDRAAQAAHRAHAQGITLREACLEMQLLDGAAFDAAVDPLRM----------------
    115 UniRef50_C6DDR5        Fumarate lyase n=17 Tax=cel...   328     4e-88  1  17.3%  39:478  21:447     --------------------------------------RAIFDDRELIRKYVEVEIALANAQARCGVIPEDAAAEITASCNADTLDFELLRHE-----TEIVGYPILPLVHQI--------------SKQAGHSGGYVHWGATTQDIMDTAVVLQIRDAFALIEADIDALRSILAGLAARYRNTPMAGRTHLQQALPITFGYKAAIWLDMFDRHAERLAQLRPRVLVGEF-AGAAGTLASLGDKGLAVQKALMAE-LGLGVPTST----WHVARDGFAEAVNLLAVITGSLGKIGYDVMLMASNEFGELYE-PFVKGRGASSTMPQKRNPISSELMLACAKGV-RQQAGLMLDAMVQDLERATGPWHAEWIAIPESFILSAGALHQAKFMLNGLIVDEKMMLKNLNMTNGlmMGLAPYIGRQEAHDIVYDAceKGGTLADVLNasSRLDPKLINDLTNPVNYLGSAPEMVDQVLNKTE
    116 UniRef50_B0T2T7        Argininosuccinate lyase n=9...   326     7e-88  1  17.0%  19:478   2:451     ------------------WGGRFSAKPAELMQAINVS---IGFDKRLWAQDLAGSRAHARMLISQGVIARDDGEEILKGLDAIEGEIVAGAFPFRD---------EYEDIHMNIEARLRELIG---------PTAGRLHTARSRNDQVAVDFRLWVREACDRSAAQLEALQKALVAQAEQYADALMPGFTHLQPAQPVTFGHHLMAYVEMFGRDASRFRDARVRMNECPLGAAALAGS------PFPIDRHATAASLGFD-RPTANSLDSVSARDFALEALSAASICATHLSRLAEEIVLWTTPMFGFVKLT--DAFTTGSSIMPQKKNPDAAELVRAKVGRILGSLTTLTVVMKGLPLAYSKDMQEDKVPTFEAFDALELSLLA-MAGMVSDLTPNTEKMAAAAGAGFSTATDLapFRDAHHvgSAVKAAETLGVDLAELSLADLRAIEpdIYTVLTPasYGGTAPAQVRAQIARWK
    117 UniRef50_B9KWU0        Fumarate lyase n=1 Tax=Rhod...   325     2e-87  1  32.6%   6:462   4:458     -----RLEEDAFGAVEILEGRLWGAQTQRALAVFGASGPRL--PVAVIRAFAAQKAAAARANLALGMLDAERAGLILAAC-ERLGQGAFDDHFPLPVWQTGSGTQTNMNVNEVLANAANMAAGQGPGTRAPVHPNDHVNRSQSSNDSFPTVMQIavAEARGRLAPELDRMAVALEERAAAFAGIPRLGRTHLNDAVPVPLSQGFAASAAEMRRSARRLSAALDELLALPQGGTAAGSGLNAPEGFDRAFCAALSEATGEAFRPAAVKVEGMAGHDALLGLSAVCEALAVALTRLCNDVRHLAAGPHAGTGELSLPDDGLTSSIMPGKRNATLAEALVQVCQHVAGCHETVSRAAASGVWDLNVSKPVLIHALLGAMEALAQGMEGFRLHCLAGIEPRRARLADNLARSMMAATALTPRLGYDRVAGLIRRAEAQGLTLRAACLAEGILGPEAFDRLVDPERM----------------
    118 UniRef50_B8IZS3        Argininosuccinate lyase n=1...   325     2e-87  1  16.2%  23:472   7:436     ----------------------WGGRFAEGpeAVAQYTDSQSYDRALYAQDIRASQAHARMLGRQGVITPEEAQLLVEGLDRVREEIRSDSFIW---------KPELEDVHMNIEARLTEIMG---------NVGKKLHTGRSRNDQVGLSFRLFVADRLETWRQRAAALCAILVQRATEHAGDILPGCTHLQPAQPVSLAHHLLAYAWMFRRDAMRLGDCLDRVRISPLGAAALAGTT------YPLDPQSVAKDVGFDGI-YGNSMDAVSDRDFVLEALFGGSTIMMHLSRLCEEIILWANPAFGFVRLP--DSYSTGSSIMPQKKNPDVAELMRGKTGRVYGSLMGMLTIMKGLPLAYNRDMQEDKEGFLD-ADRTVEASLRLMAGMMEEIAFRTDRMREACKAGFLNATELapFREAHHvgQCVAAAEKQAKGLEDLTLPEMQALEPRIGE--DVYAILDYAAAVQRR------
    119 UniRef50_UPI0001BC40C5 argininosuccinate lyase n=1...   325     3e-87  1  16.7%  20:463   5:430     -------------------SKRFHQKANAQLLQFHSS---ISFDKRLAKEDILGSIAHVKALSHAKILSIEEADTIQKNLKEILEDIEN---------QKFPFSEEFEDIHMNIEHELIRRIG---------DVGKKLHTGRSRNDQVALDMKLFVRSELRSVIELLQNLVKSLLSLAEQHLESYMPAFTHLQKAQASTFAHYLMAYVEMFFRDIQKMKNTLELLNYCPLGAAALTGTT------YPIDRDLTSSLLHFK-APTNNSLDSVSDRDYLLDSMHNFSLTMMHLSRFCEELILFSSQDYGYIE--ISDDFSTGSSIMPQKKNPDAAELIRGKTGRVFGHLFALFTTMKSLPLAYNKDLQEDKEAFFDSLD-TTKACLSIFTEMLLKIQVHPKRMKEACYQGYIEATDIapFRDAYavGAMVKAANEEDSIFQNWTLAksSLFQEDIFQMISLETMI---------------
    120 UniRef50_A7GXA8        Argininosuccinate lyase n=7...   324     4e-87  1  18.5%  19:455   9:425     ------------------WSGRFSGESSELLEEFNAS---IGFDKNLYREDIAGSKAHAKMLGACGILKPEEAAAIVAGLDAVLAQIEEGKFE---------FKTADEDIHMAVEKRLSELIG--------SELGGRLHTARSRNDQVALDFRLYVLRQNEQIARQIREFIATLTSLASAHLDTLMPGYTHLQHAQPVSLAYHLLAYAFMFKRDFERFISSHERNNLCPLGSAALAGTPH------PIRRELVAQELNFAGI-TQNAMDSVSDRDFALEILFNISVLMTHASRLCEELILWSSQEFGFV--TISDAYSTGSSIMPQKKNPDVAELIRGKTGRANGNLIALLTTMKGLPLAYNKDMQEDKEGVFDSVRTAT-SSLAILNAMMKEAKFNEQNMLAATKkaTDLADYlvPFRTAhiTGKAVAHAENLGVDLSELDAAQLKSVDENLDE-----------------------
    121 UniRef50_D1B689        Argininosuccinate lyase n=1...   324     6e-87  1  16.4%  19:475   2:447     ------------------WKGRFRGETDVRVRDFTQS---LDLDWCLAEDDIRGSLAHARMLERVGIISQEDLRRIEEGLSEILEEIRNGSFEPDPAL---------EDVHMNVEARLTAKVG---------PSGAKLHSGRSRNDQVATAVRLHLRRRLKELKGALGGLLKVLLELSERHQEVIVPGYTHLQQAQPISLGHYWMSHFWAFLRDGDRLDLALMSISRCPLGSGALAGST------LPLDRFMVARELGFEG-PTQNSLDSVAQRDALLDAHYFCVSCALHWSRLCEDLIIYASREFGWLDLP--DQFCTGSSMMPQKKNPDVLELSRGKASGVLGRFVDLACMVKGLPLTYNRDLQEDKRGLFESLS-VTGSVLEVLSALLERVEVDQTRAMECFSDGLALATDvvPFREAhkVGRLVRWCVDQGRRLHGllDEIMRFIpeDLLPLLDIrtYGGTSPSEVRRQRE---
    122 UniRef50_Q960C6        SD07650p n=12 Tax=melanogas...   323     6e-87  1  16.8%  11:463  30:471     ----------PIGSiqIPEskMWGGrtEGPHEALHSLNNSLPYDSRLYADDLDASKAYAEALHRAGLINAAEADKLVKNLELLRFDWIEGTVKIL---------PGDEDVHTVNERLLVEITG---------ELGQRLHTGRSRNDQVVTDMKLWLRKAIRETLGRLSRIIETATRQAELHLGVLMPGYTHLQRAQTVQFSHWLLSHAFALREDGQRLLELRDRANVLPLGSGALAG------NPLGIDRLWLAERLGFSGVTA-NSMHAVGDRDFVVDFIYCCSMVSLHLSRLAEDLIIYSTTEFDFIK--LADGFSSGSSLMPQKRNPDSLELIRGMAGVITANLTGIMMTIKGTPSTYNKDLQYDKQFCFQSFDKLSQ-VLEVTDGVLQTIQVKQESMEAALS-TDMLATdgVPFRQAHhiGRVVSEAEKRGVDITDLPLGdsPLFGSDIVAVADYSNNV---------------
    123 UniRef50_B0SHK4        Argininosuccinate lyase n=6...   323     9e-87  1  17.9%  19:438   3:405     ------------------EKKLWGGRFDAAPSSLMiiGESISFDQELYRHDIEGSISHSRMLRRIGILSESEQRKIETGLGQIKKEIDSGKFE---------FKIENEDIHMSIESRLTELLG---------DLGKKLHTGRSRNDQVSQDVRLYIKSEMHSILILVYDLLTVWLKKAEAHTKTIIPGYTHLQIAQPIRASHYFLSHFWANVRDFEDFYSAFERADELVLGSGALAGVN------YETDREYLRKDLNLA-RMSENSMDAVSQRDHIFKFLFASSQFMVHASRFCEEIILYTSQEFSYFKLP--DHLTTGSSIMPQKKNPDVAELIRGKAGRVIGNLTHLLVMLKGTPLSYNRDFQEDKIPLFDTVKQ-IKICTEGIRDMVEGIQIFPENATRSLRNGFSTATDLapFRSAHevGELVKHCSMKGYDL----------------------------------------
    124 UniRef50_D0CMJ0        Argininosuccinate lyase n=1...   323     1e-86  1  17.8%  23:478  31:477     ----------------------WSDRFEQGLHPfeEFNASIGFDLTLLQEDLDGSIAHARMLASVGVITEGEAEQLVEGLDTVRAEAASGSFQPGLA---------DEDVHFAVERRLIALLG---------SVGKKLHTGRSRNDQVGTDLRLWLRRRLDGLDQDLQRLQGALLTQADRHRRTMIPGYTHLQRAQPLCLAHHLLAYVEMLQRDRERLQDVRKRVNICPLGAAALAGT------PVPIDRQCTAKELGFSAV-YANSLDAVSDRDFCVEFSAAASLVMVHLSRLAEEVIAWASEEFGFVR--LSDRCATGSSLMPQKKNPDVPELVRGKTGRVFGHLQGLLTMIKGLPLAYNKDFQEDKEALFDAFRTTRDCVEAMAILFEEGLDFRVERleQDFSNATDVADYlvPFraYQLVGAVVRRCLDQRCLLRDLDleLHPAFEADLHDALAPRAVVAagGTGFERVDEQLQ
    125 UniRef50_C4L7S8        Argininosuccinate lyase n=2...   323     1e-86  1  15.7%  21:472   2:434     --------------------ALWGGRfqAADTRFKQFNDSLRFDYRLAEQDIVGSIGWSKALVSVGILTAEEQAKLEVALLALKAEVEADPEQILRSDA--------EDIHSWVEGKLIERVG---------DLGKKLHTGRSRNDQVATDLKLWCKQQGNLLLDSIHGLQTKLVATARQYQTTVLPGYTHLQRAQPVTFSHWALAYVEMLDRDYSRLQDALKRLNTSPLGSGALAGTA------YAIDRQVLALDLGFD-RATRNSLDSVSDRDHVIELMSSAALSMIHLSRFAEDLIFYASGEAGFIE--LSDKVTSGSSLMPQKKNPDALELIRGKTGRVAGALNGMLMTLKALPLAYNKDMQEDKEGLFDALDTW-HDCLDMAQLVLEDLKVNEPVTKAAAMGGYSNATELapFREAHhvGEAVVYAITQQKPLEDLSVAEFKQFNAVIAD--DVYPILSLESTLAKR------
    126 UniRef50_P04424        Argininosuccinate lyase n=1...   322     2e-86  1  16.4%  21:447   7:414     --------------------KLWGGRFVGAVDPIMefNASIAYDRHLWEVDVQGSKAYSRGLEKAGLLTKAEMDQILHGLDKVAEEWAQGTF---------KLNSNDEDIHTANERRLKELIGAT---------AGKLHTGRSRNDQVVTDLRLWMRQTCSTLSGLLWELIRTMVDRAEAERDVLFPGYTHLQRAQPIRWSHWILSHAVALTRDSERLLEVRKRINVLPLGSGAIAG------NPLGVDRELLRAELNFGAITL-NSMDATSERDFVAEFLFWASLCMTHLSRMAEDLILYCTKEFSFV--QLSDAYSTGSSLMPQKKNPDSLELIRSKAGRVFGRCAGLLMTLKGLPSTYNKDLQEDKEAVF-EVSDTMSAVLQVATGVISTLQIHQENMGQALslATDLAYYLvpFRQAHEagKAVFMAETKGVALNQLSLQELQ-------------------------------
    127 UniRef50_B5IFZ5        Adenylosuccinate lyase n=2 ...   322     2e-86  1  16.5%  18:477   5:436     -----------------PLDYRYGRDEVK----------KIFSEESKLRYMLLVEYTLMKAHAHFGNIPEYCAKAAKEAMDKVEL----------------------ERVKKIEKEIKHDVMAMVKAYAecGECGKYVHLGATSNDIIDTATALQLKDLFRYIERDFELLENALAELAAKYKNTVMLGRTHGQAAVPITFGLKTAVFLAEILRHHERFEELKKRVLVGKMI-GAVGTGAALGDGALEIQ-EFVMKELGIGYEEASTQLVG---RDRYVELVSFFSSLATSLEKFATEIRNLQRSEIGEVMEKFDVEKQVGSSTMAQKRNPITAENICGLARIIRGFL-TPMHESAILWHERDLTNSSAERFIIPHTSILIDDIMVKAANLFNNLEINEERMLENIRSNEEVmeAIIIFlsRQDAHEKLRQVSMQPGKFRENLMKDNELreGKIEELLNPKNYIGSAEKIVDNILERK-
    128 UniRef50_C8VJ67        Arginosuccinate lyase (Euro...   321     3e-86  1  14.0%  12:476   1:455     -----------MSAPKVAENMLWGGRFTQGLdlMVQYNESLPYDRILWKQDIAGSIAFARANTKSGILSAHEFSEIERGFKQIAEEWSTNTFVV---------KPNDEDIHTANERRLSEIIGK--------EIGGKLHTGRSRNEQIATDLRLWLRDELRKLDAFLSDLIKVSIARAESEIDYIMPGYTHLQKAQPVRWSHWLLSHATAFADELKRLREVTKRVNRSPLGTGALAG------NPFHIDREAMAKELGFEGLLY-NSMNAVGDRDFAMETMQWGSSFMLKISRWAEDLIIYSSLEFGFVR--LSDAYSTGSSLMPQKKNADSLELLRGKAGRAFGHMAGLMCTIKGLPTTYNKDLQESVEPLLDHIKTVGDSI-QIATGVLSTLTTIPEKMAAAlmLATEFADYlvPFrgHHISGRVVQLAEKHGVPMDQLSLEQLkrFGDDIQECLDYERAVELKDAikRAVLEQ--
    129 UniRef50_B8E0W0        Adenylosuccinate lyase n=1 ...   321     4e-86  1  18.4%  39:472  11:427     --------------------------------------REIWSDEHRYFLWWKVEEAVLEARAKFGEIPYEILKKIKEKARFSVEEIIEIEKE---------------NNHEMIAFLTNVA-------QYVGEGSEYIHQGLTSSDVMDTAFSLQIIEALNLIEDDLKRLMEEIKKKAIQYKNLPMMGRTHGMHAEPITLGFKFLSWWSELKRDLERLRVAKENISFGKF-SGVVGTLAHLS----PKIEEEACKILGLKPEPVATQVIP---RDRHAEVIYALSMIASTCERIALEIRHLQKTEVGELEE-PFREKQKGSSAMPHKRNPVLSERICGLS-RVIRGYINSALENIPLWHERDISHSSVERVIFPDSTSLTDYILNLLIGIINNLRINEERIKENMSmsQNLLLALTEkvAYGWVQEDAFRAVEQKRDFMDIVLEdeYLSEEEIKQCFSPEVFLKNIDVIFER------
    130 UniRef50_A3EQW2        Argininosuccinate lyase n=3...   321     4e-86  1  17.2%  13:478   7:462     ------------GNSEKLWGGRFSEPTDREVEMFTQS---ISFDRALWRQDIKGSRAHAAMLLKVGLLAHEEERRIQEGLSRIEEEMTNGTFPYRD---------EYEDIHMNIEKRLFELVG---------TPAQKLHTARSRNDQVSLDLRLYVIDRSREMAGLLAEFIRVLIGQSRRMRDLILPGYTHLQQAQPISAGYYFMAHAERLLRDRQRFLEIDRRLNLSPLGSGALAGTT------LPIDRNHVARSLGFSGV-TGNGLDAVSDRDFVADFLHAAVMLSLHLSGWAEEWILWSTREFGFVRIP--DRYMTGSSMMPQKRNPDVLELIRGKTGRVIGHYMGLATILKGLPLSYNRDLQEDKEHLFDAAETVRQSV-TLFSRIAGESVLDGERLREAldMAEDLVREGVPFREAHavGRIVAYCERERRKLASLTDEesPAFPEQYARVLTPENAvgPAPEQVerIREIER
    131 UniRef50_P39461        Fumarate hydratase class II...   321     5e-86  1  33.2%  27:466   4:434     --------------------------TDTAPKLFMNTGTK--FPRRIIWSMGVLKKSCAKVNADLGLLDKKIADSIIKASDDLI-DGKLDDKIVLDVFQTGSGTGLNMNVNEVIAEVA------SSYSNLKVHPNDHVNFGQSSNDTVPTAIRIavAEVTNRLLPALQQIISSLNKKAEEYKDVIKAGRTHLRDALPVTLGQELSAYADAFQHEHEQVMNILEYVKELPIGGTATGTGLNSHPEFQERVINEINRITGLGFKPA-NRFRAMRLLTDLLLLSGALRNIAVDLYRLGQDIRLMFSGPLTGLNEIDLPTQeaGSSIMPGKTNPVTVEATLLISAQVVGLDHANQFASMLGEFELSMGIPLVGYNIVTQVNFISEALEKMSRLVIDGMVANVEKMKRYAESSPSLITIVSPVIGYDKATEIGKK-LNKGMSIREALRELGY-SDNEINKILDLSKLVKPG------------
    132 UniRef50_C8X3L5        Argininosuccinate lyase n=2...   320     1e-85  1  15.3%  19:463   3:433     ------------------EQKLWGGRfaRTDSLVEQYTASVETDKHFAVQDIAGSKAHAAMLAAQGILTREEAQTLRNGLDQVADEILQGSFEWRDDL---------EDVHMNVEKRLTDIVG---------ETGQKLHTGRSRNDQVALGFRLLVSERVTAWQGHLCGVIQALVEQARQHVQTILPGYTHLQPAQPVSLAQHLLAYATMFQRDWERLNDAQKRIRVSPLGAAALAGTT------YPLDPQAVADELGFETVFA-NSMDAVADRDFVLEPLFGASCIAMHLSRLCEEIVLWANPGFGFVRLP--DAFATGSSIMPQKKNPDVAEIMRGKTGHVYGALMGLLTTLKGLPLTYNRDLQEDKAPFL-EADRTVGLSLEIMARMVPELEFLPEPMRRafLNATEFADYLvpFRQAHHigQAVAAAERAQCGLEDLSLAqsPLVDEDIYAVLDYAAAV---------------
    133 UniRef50_A9WJR8        Argininosuccinate lyase n=5...   319     1e-85  1  16.1%  19:478   6:454     ------------------WGGRFSEPTAAEMRRFN---DSFHFDVRLAEVDIAGSIAWAGALLQAGLINETEHADLVRGLELVRAEFANGSF---------VAAAGDEDIHTAVERRLRELIG---------DAALKLHTGRSRNDQVATDMRLYTIGIARQLDRRLRDLQLALLAQAEQHTATVMPGYTHLQRAQPITFGHWCLAYVEMFARDRSRLNDAIRRMRVLPLGAGALAGNS------LGVERERLTELLDEFDELSANSLDAVSDRDFVAEVLFACALIGVHLSRLAEDVILYASAEFGFLE--LADAYSTGSSLMPQKKNPDSMELLRGKSGRLLGNLVALLTVLKGLPLTYNKDMQEDKEPLFDSFDTL-DLGLQVAAAAIATMTVRPEraLDDAMLATDLADElvPFRVAhkVGQLVQRALTRGVSLRQLPLADYQAVEPSLDaiYDvaSYGGTAPQRVREQCARWR
    134 UniRef50_A1BG31        Argininosuccinate lyase n=9...   318     2e-85  1  18.4%  14:463   4:435     -------------KKELLWQSRFSEPFDRDALRFSSS---VHIDKALFREDIEGSIAHVTMLAEQDIISDAECADLVQGLREIEEELASGTLVPHW---------EDEDIHTVIENRLKEKIGQT---------AGKIHSGRSRNDQVATDTRLYLRKKIAELQDAVQAMQQMLIGKAETYKETIIFGYTHLQRAQPISAGHYYLAWFSMFRRDRERLRDLLRRVNISPLGAAAFAGST------LPLNPARTAELLAFDDIF-SNSIDAVSDRDILIEFISACSIMMMHLSRFAEDLILWSSYEFGYLE--ISDAFATGSSLMPQKKNADIAELVRGKTGRVYGNLVSMLTIMKGLPLSYNRDMQEDKQPLFDTAETTISSM-RIFTKLIGHTTLKVERLreDLSLATEIAEYLvpFREAHRigKIVTFSIGEGITLPRITLEqsPLFDSAIYDSLKPEASV---------------
    135 UniRef50_B7IJ66        Adenylosuccinate lyase n=4 ...   318     2e-85  1  15.4%  39:473  21:443     --------------------------------------RTNFSDENLIQLWLNSEVALAKAEAKLGIIPQNAATNIANAADQNKLDFNK--------------------IREGMKKTGHPFVahEFESLCDEESRKYIHWGATTQDIIDTGLTLQIKGAHELIYNQTQEILKICLRLSQQYKSTVMPGRTLGQHALPITFGYKISIWSDELGRHLERLQQGADRYLVGQLG-GAVGTLASLGAQGLA-VRKEYVKNLNL----IEPLVSWHTSRDRFAEFSMILNMIGATTAKVAEEIISLQGTEIREVEEGYH-SGKVGSSTMPHKRNPMTCSYIVGLTKIVNRK-STLAIDSMIQKHERDVTFWQSEWSYISEICITLSGALEQLKNVLTNLIVNEEQMKKNLFLTKGlmLELGKIIGRTTAheLTMRAFEEDKDLKDILLEdkYFSDEEINSLTNPESYTGLSEKFVDDV-----
    136 UniRef50_B5YF29        Adenylosuccinate lyase n=1 ...   316     8e-85  1  18.2%  39:472  11:427     --------------------------------------RDLWSDEHRYALWWKVEEAVLEARARLGEIPFEVLKNIKERVRFSVEEIR---------------EIEKENNHEMIAFLTNVA-------QYVGEGSEYIHQGLTSSDVMDTAFSLQIIEALNFIEDDLIKLMEEVKKKAIKYKDLPMMGRTHGMHAEPITLGFKFLGWWAELKRDLERLKKAKENISFGKF-SGVVGTLAHLS----PKVEEEACKILGLRPEPVATQVIP---RDRHAEVIYALSMIASTCERMALEIRHLQRTEVGELEE-PFREKQKGSSAMPHKRNPVLSERICGLS-RVIRGYISSALENIPLWHERDISHSSVERVIFPDATSLTDYILNLLIGIVRDLRVNEERIRENMMmsQNVLLALTEkvLRDVAYVWIQeaMEQKRDFMEIVLEDsyLSREEIERCFSPEIFLKNIDVIFER------
    137 UniRef50_Q49YV3        Adenylosuccinate lyase n=82...   316     9e-85  1  16.4%  41:473  13:428     ----------------------------------------IWTDQNRYEAWLEVEILACEAWSKLGDIPAEDVKKIRENAK---------------VDVARAQEIEQETRHDVVAFTRQV-------SETLGEERKWVHYGLTSTDVVDTALSYVIKQANEIIKKDLERFIDVLAQKAKDYKYTLMMGRTHGVHAEPTTFGVKMALWYTEMKRNLERFKQVRKEIEVGKM-SGAVGTFANIPPE----IEAYVCEHLGLDAAPVSTQ---TLQRDRHAYYVATLALISTSMEKFAVEIRNLQKTETREVEEA-FAKGQKGSSAMPHKRNPIGSENITGIA-RVIRGYVTTAYENVPLWHERDISHSSAERIMLPDVTIALDYGLNRFTNIVERLTVFEDNMLANIDKTFGLIYslAREAAYDKVQPKAMESWETKTPFRTLIEEDalLTKEDLDECFNPKHHLNQVDTIFQRA-----
    138 UniRef50_Q66J94        MGC81570 protein n=4 Tax=Eu...   316     1e-84  1  17.6%  20:463   6:410     -------------------NKLWGGRfdPIMEMFNCS---VNYDQRMWSADIRGSQAYVKALEKAGLVSKSEMEQIISGLDKIHDEWSSGTF---------VLTKGDEDIHTANERRLKELIG---------EVAGKLHTGRSRNDQVVTDMRLWLRDSCSTLYTHLTRLIQTMVERAAIEVNILFPGYTHMQRAQPIRWSHWILSHAVALSRDAERLGEVKKRVNVLPLGSGAIAG------NPLGVDRELLCK----------------------AEFLFWASLCMTHLSKMSEDLIIYSTKEFGFV--TLSDSYSTGSSLMPQKKNPDSLELIRGKTGRVFGRCSGFLTTLKGLPSTYNKDLQEDKEAMFDVYDTVC-AVLQVASGVIATLQINKEAMEKALslSTDIAYYLvpFRQAHGvgKVVQLAETKGMSVDKLTLelKSISPLFSDDVSKVWNYT---------------
    139 UniRef50_A1B109        Aspartate ammonia-lyase n=1...   316     1e-84  1  41.8%   5:451   8:452     ----TRIESDELGSRRLPGEALYGINTLRAAENFPVSGMKIGSLAPLIRAMALTKKAAAAANYRLGKLSARKAEVIGRVCDELMA-GQHAGHFVIDVFQGGGGTSSHMNLNEVIANRGLELMGRACGQYEHLHPIRDVNRSQSTTDVHATALRIALMQGAPGLERALLALAEAFAGKAQEFGGILKLARTHLQDAAPMTLGEEFHAFSTALRHEAARIWPASQGLAGLNLGGTMVGTGLAAQPDFAETVIAELQRLTELPLRRDDDLVCAAWNSAGLVQFSSLLRGIAVTLSKIANDLRLLSSGPRGGIGEISLPAVQPGSPLIAGKVNPVIPEMVSQVAFHVAGADVAVGMAAEAGQLQRNAFEPLMAHCLLTSLGMIESAARIFAERCVQDIRAAPEACAGNLSAPGTLAAGLVPLVGRAAAADI-SEAVARGEDLGALLRGQGLASGD---------------------------
    140 UniRef50_Q59092        3-carboxy-cis,cis-muconate ...   315     2e-84  1  17.8%  40:478  16:447     ---------------------------------------EIFSDRALVSYMVEAEVALAQAQAQVGVIPQSAATVIERAAKTAI------DKIDFDALATATGLAGNIAIPFVKQLTAIVKDADE-------DAARYVHWGATSQDILDTACILQCRDALAIVQNQVQQCYETALSQAQTYRHQVMMGRTWLQQALPITLGHKLARWASAFKRDLDRINAIKARVLVAQLG-GAVGSLASLQDQG-SIVVEAYAKQLKLG----QTACTWHGERDRIVEIASVLGIITGNVGKMARDWSLMMQTEIAEVFEPTA-KGRGGSSTMPHKRNPVAAASVLAAANRVPALMSSIYQ-SMVQEHERSLGAWHAEWLSLPEIFQLTAGALERTLDVLKGMEVNAENMHQNIemAEAVMMALAPHMGRLNAHHVvkTAVAEQKHLKDIISqkQYFNPSQLDEIFKPESYLGNIQDQIDAVLQEAK
    141 UniRef50_B4KEY6        GI12353 n=3 Tax=Endopterygo...   315     3e-84  1  17.5%  19:463  19:444     ------------------WGGRFSEQPHEALQELNIS---LPYDARLYADDLDGSKAYAEALMRAGHLNAAECDKLVKNLELIRYDW---------VEHLIKFEASDEDVHTVNERLLVELTG---------DLGQRLHTGRSRNDQVVTDMKLWLRKAIRETLGRLRQLIEAIVRQAEAHLGILMPGYTHLQRAQPVQFSHWLLSHAFALREDCQRLTELRDRSNVLPLGSGALAG------NPLGIDRAWLAERLGFAGV-TGNSMHAVGDRDFVVDFIYCCSMVSLHLSRLAEDLIIYSTKEFDFIK--IADTFSSGSSLMPQKRNPDSLELIRGISGLITSNLTGIMMTIKGTPSTYNKDLQFDKQYCFQAYDKLTQS-LNIAVGVVETMKVQRHQMESALS-SDMLATdgVPFraHHHIGCVVALAEQRGVDITEVPLGELqaFGADIASVADYGHNV---------------
    142 UniRef50_A9IZG7        Argininosuccinate lyase n=2...   315     3e-84  1  17.5%  23:457  11:428     ----------------------WGGRfaGPAAVMEEINASIDVDQKLYRQDIEGSLSHAAMLAQTKIILQSDYEKISHGLKIILQEIEEGDF---------VFSRNLEDIHMNIEARLSALIG---------PVAGRLHTARSRNDQVAVDFRLWVRETLQKIAQALKQLIKQLLILAEQHVKTYMPGFTHLQLAQPVTLGHYMMAYVEMFGRDLSRMRDASERMNESPLGAAALAGTS------FPIDRFMTAQALGFR-EPTRNSIDSVSDRDFALEFLSAGALCAMHLSRLAEEIILWSSEQFRFIY--LSDAFSTGSSIMPQKRNPDAAELVRAKTGRLNGALMGLLTVMKGLPLAYSKDMQEDKEYVFDGALSLELS-LAAMTGMIADLEVNKKAMKQAADLGYATATDFapFREAHhtGQAMALAEKKQCRLQDLSLDELQAICPDINATL---------------------
    143 UniRef50_C1DFC3        Adenylosuccinate lyase n=1 ...   314     4e-84  1  15.9%  39:478  21:448     --------------------------------------RRIFSDETTVQRWLDVEAALAKVQGELGIIPRAAADEIRRKARVELIDLGALKAEMDRTAHP------------------IVPLLRAIKRVCDGDAGEYVHWGATTQDIVDSGTVLQLRDGLEEIERDLRGLLDNLLKLAATHRDRVMVGRSHGQQALPITFGFKVAVWAEEIRRDLQRLDQMRERVLVGQF-AGAVGTLSALGEHGIA-VQEGLFRELGLGC----PSIAWHVSRDSLAELASVLAIATGSVGKIAHEIYALQKTELGELEEPFSP-GKVGSSTMPHKRNPAACETVVALA-RVVRSIVPLALEGVLAEHERDKIVLQTEREYLARLFGLSHAAIAKTRAIAAGLTVRGAHMEENLYrsEAVMMRLSDALGRQEAHEIvmEVFEREGTLKEALLADPllSPEEIDALLDPKAYTGLAGAFVDRVTARRQ
    144 UniRef50_O28041        Adenylosuccinate lyase n=5 ...   314     5e-84  1  18.1%  18:475   5:437     -----------------PIDYRYGTPEMK----------RIWSEDSKIKRMVRVEMALLRALAKKGYLS----------------------EEEAKEAKKKAYSVTPERVKEIEAEIKHDIMALVKAITEAT-GCRWVHFGATSNDIIDTATALQLRDSLKILEVKIKRLAKVLADKALEYKDVVCLGRTHGQAALPTTYGFRFALWAAEVARHYIRLQQMKDRLLVGQM-SGAVGTQAAFGKDGFEI-EEEVMRLLNLKPALISSQIIP---RDSYCEYLEFLANLAATLEKIALNFRLLQRAEVGELME-KFEAKQVGSSTMPHKRNPIDCENVCGLARVVRG-FVEPQHQSAILWEERDLTNSSAERITLVESTVLADHILTKMIKVVSSVSLNLENIRRNLEmsEAVMIEMtrGVGRQEAHEILRQAaeNNSSLLDELLKdkYFKEDELREILKPENYLGTARERVERVVR---
    145 UniRef50_B3E105        Argininosuccinate lyase n=1...   313     1e-83  1  16.7%  19:472   4:449     ------------------NKALWGGRfeKPSSLFLQFSQSVSFDWRLYKQDIKGSIAHARMLEKIGIIDPKESEEIQRGLTEILEEIEEGQFKWSTQL---------EDIHMNIESALI----------NKTKAGLKLHTGRSRNDQIATTMRLWVKEEVQKILSLLSRLQAVLVLWAEENIEVVIPGYTHLQKAQVVSLAHQILAYVEMLERDKEKFKECYNNTDVLVLGSGALAGSS------IELDREYVANLLGFSRIS-QNSMDGVSDRDFVLDFLYGASTLGIHLSRFAEDMVLWSSSEWGFLELP--DAFSSGSSLMPNKKNPDCFELLRGKSARLISNLNRLSILLKSLPLTYNRDMQEDKEPLFDSAD-TVESCLEMLIAMIPKLKIKKSLCLKqlLFATDIADWLvpFraHHKVGELIGYCQKNSLSLAAVPSAVLDAIHPELSkfFDPHKSLepNPDLVRK------
    146 UniRef50_A2Q840        Contig An01c0080, complete ...   313     1e-83  1  14.4%  35:477  45:477     ----------------------------------TEEIRKVFDDEAYIKRCMDAEAALARAQSRCDVIPSQIGEMVTRKLRESKLDMERL------------------RYETEIVGYPILPLVRQLSAICGDEAGKYVHWGATTQDIMDLASVLQMKEGLDIVEHHLKKVISTLRGLSVKYKDTPMAGRTHLQHALPVTFGYKCAVWLSGFQRHLERLEQLKDRCLLVQFGGAAGSMASLGTGDDGLRVRKALAEELGLTDPP----ITWHVARDGIAEITNFLALMGGSMGKLALDIIIMSSNELGEVSEPFVP-HRGASSTMPQKRNPISSEVILA-ASKILRSNAGLVLDGMVADFERASGPWHLEWVAIPESFVIAVGALSQTQFALSGLCVHSQKMLENLHSTKGlmMGLAPHVGRQQAheACRESIEANQSLLECLMKksKMSEERLSQLYDPVNYLGASTRMVEDVLAVD-
    147 UniRef50_O42889        Uncharacterized protein C8E...   313     1e-83  1  15.8%  38:475  20:445     -------------------------------------IRKIWSDENRTQEYLNWEAALARAEASLGIIPKYAGEEIQRVCKVENIDFSKLEEETINIGYPVLG------------------VVHQLANLCSGDSGKYCHWGATTQDVTDSATVRQMIDSFKIIKGYLEKAIELATVLVIKHRETTMAGRSNLQQAVPITFGFKMARFVATLRRHHQRLCELLPRVSVLEFG-GACGTLASLENKGL-MVQQKLAEELGL----LQPEIAWHTERDRIAEAGCFLGMLTGTLAKFATDIKLLMQTEVAEVFE-PFKANRGSSSTMPQKRNPISCVYITASTSFV-RQGVAALLDAMVEDHERATGAWEIEWIVLPDVFVHTVGTLKQTVFLLEGLEVHPSRMNENLSisEAVMMALAPKLGRDEAHDLVYrsIQENKPLVELLLAEryLSKEEVTSLLNPENYLGSTFEMIERALQ---
    148 UniRef50_A4SIM6        Argininosuccinate lyase n=1...   312     1e-83  1  16.0%  21:475   2:437     --------------------ALWGGRfqGADSRFKQFNDSLRFDYRLAEQDIQGSMAWAKALVKVGVLTADEQGKLQQAMEVLLASVQQDPHQILNSDA--------EDIHSWVESQLIAAVG---------DLGKKLHTGRSRNDQVATDLKLWCKAQGELLLGSISALQAGLVASARANQAAVLPGYTHLQRAQPVTFAHWALAYVEMLERDYSRLQDALKRLDTSPLGCGALAGTA------YAIDREALALDMGFGGA-TRNSLDSVSDRDHVVELMHVASLSMTHLSRFAEDLIFYNTGEAGFVE--LSDAVTSGSSLMPQKKNPDALELIRGKTGRVVGAQMGMLMSLKALPLAYNKDMQEDKEGLFDALDTW-HDCLDMAALVLIDLKVNVERTKAAAQGGYANATELapFREAHhvGETVVYALEVKKPLEDLSLPEFQRFSPVIGE--DVYPNLELEATLAKRVAK---
    149 UniRef50_A9H6Y6        Fumarate lyase n=7 Tax=cell...   312     2e-83  1  17.4%  39:475  21:444     --------------------------------------RKIWSDSGRTEQYLAVEAALSEVQGRLGIIPADAAKKIASVCL-----LEKIDMVRLADETAEIGYPVLPLVHQI--------------QSLAGDAGDWCHWGATTQDITDTATVLQIKASLDVVADLLERCIAAASGLARAHRDLPMVGRSNLQQAVPITFGFKMARLAACLLRHRERLAELRPRIEVLEFG-GACGTLASLGDRGLD-VQKVLADTLGLARPP----ITWHTDRDSIAETACFLGLVTGTLSKFATDLKTMMMTEVNEAAE-PFVLNRGSSSTMPQKRNPISCCYITACAASV-RQSTAALLGSMDADHERATGPWEIEWIELPRIFSLASGALSQAAFVIEGLEVNGDRMAANLgmSEAVMMALAPKIGRGQAhkVCRAALEQNRSLAEMLKADDAVTEqqIDHLTDPARYLGCAGEMIDAVLA---
    150 UniRef50_B4MKH2        GK17051 n=1 Tax=Drosophila ...   311     2e-83  1  28.9%   1:457   1:446     MENHRrlERDALGSLEVPNDRYFGAQTMRSSLQYHIGGQEERVPRAVIQAMGIVKKAAAEVSQEFG-LDPEISSSIAKAADEVITGQLYDehFPLHIWQSGSGAQTNMNVNEVISARANEIMG---GTQDPVHLYDHVNNLHSSNDTYPTAIHIAviELTHRLKPALTLLHDSVKAKSTGCNKIIMMGHIKtkDAGPTTLSQNFSDYAHQLSNCLERLEAVLPRVWQLRMGETTAGTGHSIRKGFAGKCIERIAQITSLPFAKTANFMESLGARDAMVEVHGALNTIAASIMKIANGVRFLCLDPRNGLSET-----EGGS---PG--NLSHCEVLTMICVQVMGNHVAVTIGGNNGHFELNAFKPLVASNVLRSIKLLTDGCISFNDNCLRAINDNKENVAKMMGDSLMLASTLEPHVGFERACQLAASALMNGTTLKDECLRIG-ISETQINDWL---------------------
    151 UniRef50_P74384        Adenylosuccinate lyase n=8 ...   311     3e-83  1  16.6%  40:474  12:430     ---------------------------------------KIWTDTYKLQTWLDVEIAVCEAQAELGYIPQAAVDEIKAKAK-----------------------FDPQRVLEIEAEVRHDVIAFLTNVNEYvdAGRYIHLGLTSSDVLDTALALQLVASLDLILEQLEKLIQAIRYQAQQHRYTVMVGRSHGIHAEPITFGFKLAGWLAEVLRNRDRLVRVAQSIAVGKI-SGAVGTYANID----PKVEAIACQKLGLEPDTASTQVI---SRDRHAEYVQQLALLAASLERFAVEIRNLQRTDVLEVEE-YFSKGQKGSSAMPHKRNPIRSERLTGMARLVRGHAVA-ALENVALWHERDISHSSVERVAFPDCCILTHFMLKETTDLVKNLLVYPENMKRNMNVYGGVilALVEkmNREDAYRVVQGSatEGGNFEELVRAdaLLSAEEIDQCFDPQQHLTNLAEIYSRLD----
    152 UniRef50_Q5LZ30        Adenylosuccinate lyase, put...   311     3e-83  1  15.5%  32:476  12:446     -------------------------------NNftPAIRSIWSDDNKISKQLAVEAALAKIEGDLGIIPKSAADKIVEKAK--------VDNFDFLSLQKESA----EKRHSLIA------LIHALQEEVGGKEGEFVHYGVTTQDIVDTGIMLQTKEAYNIILDHTKDLISTLAKLTKEHRSTLMIGRTHGIHAIPITFGFKLSIWLDELLRSQRRLKQLLENDVFVGSISGAVGSYASFFGRGRE-VEKAVLKELGL----AVPNISWQPSRDRFSEFASVLGIFSGTLGKIGRELFTLMKTEIDEVHE-PFKKGEVGSSTMPQKRNPALIEGLASLTQPVFK-DVDLMFQSLLIDGERDAIHWRNEWVALPEITSYLDAQIVNATYILSGLKVNQDKMLDNLNksERIMFEVGLKLGKQTAHEIVYqaLEENKDFIDLVYSDERvtKEDILSWVDPKNNIGECLEKVDEVLSQ--
    153 UniRef50_C0CW88        Putative uncharacterized pr...   310     6e-83  1  16.8%  39:478  21:448     --------------------------------------RTIFDDRTIIQNFLDIEKALAQVQGEMGIIPKEAADEICKKGFVENLDIGEIEAGIVKVGHS------------------LVPILRNFQKKCDSGYGEYIHLGATTQDILDTGFMMSVKRGFEAVYRDALEAEEAVLDLVDRYADTVMAGRTHGQQAIPITFGYKAAVWASELRRDIERMEDCRKRCFVGQL-SGAVGSMAGFGENGREISRRVI-EALGLD----VPDISWHVSRDRLAEIVSVLATLGCTFGKIGQEIVYLQGTETGEAAE-GFVHGAVGSSTMPHKRNPVAPEALQTLS-RLAKAGMGATFDSMYQFHERDGASWKIEWMSVNETVMLVGGVAAKGKKLLKNLDVFPERMKANLdmSEPVMLELGKKIGKQTAHEVVYeaFEEQADFKAKLLENEVvtEAELDALLDPERYTGDCAAIAREVSASIR
    154 UniRef50_B1ZZY3        Argininosuccinate lyase n=6...   310     6e-83  1  18.1%  16:463   3:441     ---------------KTSSQATWGGRFTAAPADLmqFSESVSFDRRLAPFDIAGSKAHSAMLAHVGLITAAERDAIHAGLDAILAEIKAGKFKW---------EVKLEDVHMNIEQALTRRV----------PAAAKLHTARSRNDQVATDMRLWFKHACGVLAQKIAGAQRALLEVATANRTVLIPGYTHLQRAQPVFLAHHLFAWIEMLDRDGARFRDVAEHANWCPLGAGAIAGTT------LPIDREFTARALGfrPQVTQNSMDTVADRDLFIEFAAACALFGVHVSRIAEDLILWSSAEFKFAELP--DAFCTGSSLMPQKKNPDACELLRGKSARLQGNLHTLLTLTKGLPLTYNRDLQEDKPPVFDSFDQTAL-CADVLAGTVTGMKIQVERCAAAVSDPALLATDlvPFREAHHagAVVRLAEKNNAALNQIPTEEmpAFEEDWAEVFDLGRAL---------------
    155 UniRef50_B4U5U1        Adenylosuccinate lyase n=2 ...   308     2e-82  1  17.2%  39:473  11:431     --------------------------------------AEIFSNLNKYKKWLEVELSVLYAMAELGIIPKEAYKVIDSKAY--------------------VDESVEKKIDEYERIYKHDVLAFVSAIGelGEYSKYFHMGLTSSDILDTALSLVLKDAIDSIIIDIDIVLELLKEKAFRYKDSVMMGRTHGVHAEPISVGLKFASWYDELKRQKERLQVAKKDVLKGKI-SGAVGTFSNVDPE----VEKIALQKLGLEPEPAPTQIV---HRDRHAYLMSVLSLIGSSLEKFATEIRHYQKTEVLEMEE-PFSESQRGSSAMPHKKNPIHAERICGLA-RVMRANMIAAFENIALWHERDISHSSAERIIIPDTFIGLDYMFGLFEYILKGLKVNTDRMLKNMDISKglVYLMQKGVDRDSAYDIVKRCAMRSWdfKDALLEdkYLTKEDLDKIMDPYEFIKHRDYIFKRV-----
    156 UniRef50_C9KN76        Adenylosuccinate lyase n=1 ...   308     3e-82  1  15.8%  40:477  22:446     ---------------------------------------EVFSEKSWVQKWLDTEAALAQAQGELGVIPKEKADIIVKYAKADLIDIPSIGEG-------------------YKSSITIVPLLNAFKKILPEHAGEYVHWGATSQDIVDTGMVLLERDAYDIILRDAKACLKAILKLVKKYRDTPEAGRTHVVHAIPITFGYKAAVWADELGRQIERFEGMKKRVFVGEM-AGAVGTLASQPEKGLETQQRMF-EILGLE----VPTIAWHVARDNQAEFASMLALLAGTLGRIAHEIFTLQRTEILELEEPFF-MGKVGSSTMPHKRNPAVLENVLALLRNVRGIAPTV-VESMVSENERDWGCFISEWEAIPRACELMATALHKTKYILENLIVYEKHMERnlMMSECVMMHLARKLghHIVYNACMEAYEKEIPLKDVLMkeDAFTEEEIDYMLNPHNYLGLAPVFCDRVLAKY-
    157 UniRef50_D1JDZ4        Argininosuccinate lyase n=1...   308     4e-82  1  19.0%  38:478  11:458     -------------------------------------IQSLESDRWLFYADLLVDKAHVVMLKERGIIKKEEAAEILKFLTKIKEKDFIELELP-----------SYEDLHTAIESVLIREIGEAM--------GGRMHIGRSRNDEVATCIRIALRDELLELMKEVNYLRRALIEKAAENVDTLIPGYTHLQHAQATTFAHQYLAHADALARDFSRLLNAYEHTNLCPLGAAAFAST------GFPIDRAKTTKLLGFNSIL-ENSMDAVSSRDFIIESISCFSNLMTNLSRLAEEIILWSTSEFDFIRVPV--EYVTGSSIMPQKRNPDYAELIRARAGTVYGCLMSVLSICKALPYSYNRDLQEVTPHLFKATEYTTASVL-VMTGMVKGLELKKDKLEKQTQIGFISATELADTIVrrTAHKIVSRLAEEgrRIDELalSEIGLTERKVKEALNIASNigPAKREVLRMIDRRK
    158 UniRef50_D2R2G4        Argininosuccinate lyase n=1...   307     5e-82  1  16.8%  20:478   7:454     -------------------SGVFSKATDRRVELFTES---VSFDRRLYAHDILGSCAHATMLAKVGILTSDECEQICTTLKAIGSEIESGNFPIRTEL---------EDIHMHIEQALIDRLG---------DVGRKLHTGRSRNDQVSTDLRLWVRDALDRVDGLLANLQRAFVGRCDADFDVILPGYTHLQRAQPVLAPHYWLAYAEKFARDRARVADCRKRTNICSLGVAALAGTT------LPIDRFETARLLGFD-EVAANSLDVSSDRDFVLESAFVLSMISAHLSTWAEEWILWSTAEFNFLKLPHD--FCTGSSIMPQKINPDVLELTRGKTGRVIGNLQTLLVLIKGLPLAYNRDLQEDKPAIFDSFD-TVEICLELAAPLVAGATLLRDSINERLDRGHLDATTLmpQRTAHhvGTLVKMAMAEGKRLSDLPASEY----EKLDSRLDarSYGSTAPVEVRRQIDRWK
    159 UniRef50_A1TS34        Adenylosuccinate lyase n=2 ...   306     9e-82  1  15.7%  19:478  11:448     ------------------LQHLWGTDELR----------TIFGEENRVQKWLDFEAALAAAQAEMGIIPAAAAREIAEKARVENIDIAKMSAEIRRIKHS------------------LVPALRQLQAACSRENGEWVHYGATTQDVVDTGVALQLKEFHAVAMRDLQAVGRELARLAVAHRDVPMAGRTHGVQALPITFGHKCALWLDELGRHHERLVQAAPRVLV-GMLAGAVGSQASLGPKAIELEERMLGK-LGLG----VPAISWAPARDRFAEYTNLLAMLGSTLSKIGNELFNMQRNEFGEVEE-GFSEGKLGSSTMPHKRNPTSAENLAGLS-RPLRYNAAMMVEGMVSESERDGIAWKMEWKAVPECCMIAGAMLFQAKNLLAGLKVNADVMAANLDksERVMLELSERVGKQTAHEWIYEASMHGItfADAMRQHklLTDAEIQDLTDPAGYLGQCGTSVDRVVAAQK
    160 UniRef50_D2RG73        Argininosuccinate lyase n=1...   306     1e-81  1  19.4%  19:477   2:436     ------------------LRSRFKKQMDPLALEFTSS---IDQDRYIFYYDILVDLAHVLGLLKCGHISRDDAKAIIRALLEIRDKGY------------EAIPKEYEDVHEAIEAEVTKL----------TQAGKKMHTARSRNDEVATCLRMFARDRLLSIASAILDLRRVLLKRAEESIDVIMPGFTHLQYAQPTRLSHHILAYHDMLKRDFDRVIETFRRVNLSPLGACAFAGTS------FELDRNYTAELLGFDGV-VENSCDAVASRDFLIESVFVATQLMLTLSRMAEEIVLWCS-EFDFIDLP--EEYASTSSIMPQKKNPDVAELIRAKAGRLIGNLTGVMSIYKAMPLTYNRDFQEMNEILFKSLEI-ADLSTILMAGMFEKIVFKTDVMREKVLKSFTVASEIADRLTkrDAHRIVGRAVAEG-DLSKVLDIAKEMsdVKVDLDVSVEEVvgTSKSEVLRMIEDR-
    161 UniRef50_D1SZ88        Adenylosuccinate lyase n=1 ...   306     2e-81  1  15.9%  19:476  11:446     ------------------LQHLWSTDEVRA----------IFGEENRVQKWLDVEAALASAQADMGIIPRDAAREIADKARVRHIDIGRMSADIRRIRHS------------------LVPALRQLQAACSADHGEWIHYGATTQDVIDTGVALQLKEFHAVALRDMRAVGRELARLAVEHRDTLMAGRTHGVQALPITFGHKCAVWLDELGRHHERLVQAAPRVLV-GMLAGAVGSQAAFGPNAAE-LEERVLRRLGLGVPP----ISWAPARDRFAEYANLLALIGGTLSKIGNELFNMQRDECDEVEE-GFPEGKLGSSTMPHKRNPVSAENLAGLS-RPLRYSAAMMVEGMVQESERDGIAWKVEWKALPEACMIAGAMLFQARHLLAGLKVNAAAMAANLGrsERVMLELSARVGKQTAHEWIYEASMHGItfAEAMRHHelLTEDEIHDLTDPAGYLGQCGPAVDRVVAA--
    162 UniRef50_D0U617        Argininosuccinate lyase n=2...   305     2e-81  1  16.8%  19:453  10:426     ------------------WHGRFSSGPAEELLAFTES---LSFDKRLWKDDIVGSLAHVKGLGHAGILPLSEVAQIESALHQVASEFVNGTFQFVA---------GEEDIHTSIERRVTQIAG---------PVGGKVHTGRSRNDQCVTALRLWTKRELAALAERLIALCDVLTQRADlsDGVYLPGYTHVQRAQPVLLAHHLMAHAWAFTRDIDRLISTIKRADVSPLGAGALAGSS------LPLDPNFTAREMGFADRF-SNSLDAVSDRDFVAEALFDLALIGTHLSRIGEEWVLWTSEEFGFA--TLDDRYATGSSMLPQKKNADIAELARGKAGRLIGNLTGLLTTLKGLPLAYNRDLQEDKEPLFDSYDQVSLAV-GALTGMIQTATFNSDRMREAAdsATDLAEYLvpFRQAHavGELVQKAISGSQSLQQLVADSPEFDADAL-------------------------
    163 UniRef50_C6CGJ3        Adenylosuccinate lyase n=11...   305     2e-81  1  16.5%  39:475  21:444     --------------------------------------RAVWSEQNRLTRQVDVEIALALAEGELGVIPQDAADTIASHANASALNIEEIAQDAVRMKHSLMPTIA-------------------AIQKQCGEAGEYIHYGVTTQDVVDTATVLQLSQAFDIVVRDTRLVAIELKRLAKKHQHTLMTGRTHGMQALPTTFGFKLAVWLDEFVRHLQRLNEIRDRVLVGNI-NGAIGTYASFGELGPEIERHTLAR-LGLN----TPNIGWQSARDRFSEYASVAVLVSGTLGKIGNELYNLMRTEINEIEE-PFSEGKIGSTTMPHKRNPAALEGLASLTAPLFKS-AALIHESMKVEHERDAMSWRAEWIALPEINIYLSAQLQNALGILRGMSVNEKQMRANLdlSEKVMFEIGKLLGKQTAHHLVYeaFEQNREFKALLLEHPVLsaDTLDAWLDPANYVGSAPQKVDEVIR---
    164 UniRef50_Q7UK64        Argininosuccinate lyase n=5...   304     3e-81  1  16.7%  20:475   7:438     -------------------SGVFQAETDARLEAYAES---ISFDSRLYEHDIRGSIAHANMLREVGLLTEDEFKLIRDTLETIRGELDRGELPMR---------FELEDIHMHVEQALIDRIG---------DTGRKLHTARSRNDQVSTDTRMWIRQSLDEIDALLVDLQSAFLSRCENDFDIILPAYTHLQRAQPVLAPHYWLAYIEKLERDRQRIADCRKRVNQCSLGIAAVAGTT------LPIDRQHTASALDFEGITA-NSLDTSSDRDFVVESTFVMSLIASHLSGWAEEWILWSTVEFDFIQIPQ--AFCTGSSIMPQKVNPDTLELTRGKSARVMGALQTLMLLIKNLPLAYNRDLQEDKPPLFDAFD-TTRAMLELAAPIVRGAELKRESIAARIEKGYLDATTLMEWmaHHLVGAIVSEAMQQGVTLSDLPLETYQKLSDQIDE--SVYEVLGTSNAIAAFRSE---
    165 UniRef50_Q2PYG7        Argininosuccinate lyase n=1...   304     4e-81  1  18.7%  16:459   5:426     ---------------NTLWHGRFAGGPAEALQKLN---DSLPFDQRMFREDIAGSRSHVRMLESVGLINKEELDAIMAALLQVENEIAEGTIRWAA---------NDEDIHTAVERRATEL----------APAAAKMHTGRSRNDQVANDVRLFVKSEVDDLVSLAFELIAVIRTRAEehAeiYLPGYTHMQQAQPVSLAHHLAAYCWMLLRDVDRLKDAKRRTDVSVLGAGALAGSS------LPLNPAFTAADLGFD-QLFENSLDAVSDRDFVADVLYALTTLGIHLSKLGEELVIWASSEFAFI--TLDDAFSTGSSMMPQKKNPDIAELARGKAGRLIGNLTGFLATQKGLPLAYNKDLQEDKEPLFDSCDTARLTLLAL-RGMIQTLDFNAEAMKLAADSPYAAATDLapFRDAHavGGLVRDSLAGAKSFAELVRDHPNLGHEA-QKLLEP-------------------
    166 UniRef50_Q6L0V1        Adenylosuccinate lyase n=4 ...   304     5e-81  1  17.3%  18:474   5:439     -----------------PIDYRYGRD----------NVKYIFSEENRMRLMLRVEAALAQAEYEYNIISRDAFLDIKNAVDSNSVRI--------------------ERVHEIESRIHHDTMALVEALTEQCSAGkfVHFGVTSNDIIDTATAMQIKSAVKIIKDDIKNLMKTLIKLIDENKDSVMVGRTHGQHASPITFGLKLSVYLDEMSRHLKRLTEAGDRI-VAGKISGPVGTGASLGKDSIEIQ-NRVCEILGIKSEIASSQIVC---RDRYIEYLSIINNIATSLEKFATEIRNLQRPEINEVSEYFDERSQVGSSSMPSKRNPIVSENISSLC-RFIRSLIIPEYEAAVIWHERDLANSALERFTIPYASVLIDYVLYNMNDVFSHLYINKEEMLreFIMSESIVRALtsGMPRQEAHEFVreAYKNNKSLKSSLIslKYIDEKTLEAAMDPVKFTGQAVSICNNVI----
    167 UniRef50_C9KQG3        Adenylosuccinate lyase n=1 ...   304     6e-81  1  17.2%  40:463  12:418     ---------------------------------------HLWSIENEWQQILNVEMAACDAMAELGEIPKEAAKNIRAKAKFDVN-----------------------RIHEIESVTHHDIIAFLTNVAENvdDSKYIHKGLTSSDVKDTAYCMMMRDACTIILDDLKKFREVLRRRAKEFKHTPCIGRTHGIHAEPMTFGLKLLLWSAEIERDIERMEHAKKIVSVCKL-SGAVGTYSNID----PKIEQMVGKKLGLTPVRLATQVIQ---RDRHAEFVTSIAICSSTLEKIATEVRNLQRTDIRE-AEEYFSPGQKGSSAMPHKRNPINCERISGMARLNRGNAVA-ALEDITLWHERDISHSSVERVILPDSSINLDYCTQKLTDIIDKLLVYPDKMLHDMNRTGGLilSVVDkvLREDAYKWVQRnwMEGQDFRTSVENDpyLTKEEIDDCFDYKYFL---------------
    168 UniRef50_Q0AM30        Argininosuccinate lyase n=7...   303     8e-81  1  17.4%  20:455  15:433     -------------------SAMWGGRFSAGPSamEAINASIDIDQRMADQDIDGSLAHSRMLAATGVISSADAAAIQRGLEQVRSEIHAGDFPWSKAL---------EDVHMNVEARLKEIIG---------EPAGRLHTARSRNDQVATDFRLWLRDACDRIDAMLAAYQTALVKQAETHADQVMPGFTHLQTAQPVSLGHHLLSYVEVAQRDRGRFADARKRLNESPLGCAALAGTA------FPIDREMTASDLGFD-RPMANSLDGVAARDFALEVLSAASICAVNLSRFAEEIVLWCTRRFGFA--TLSDAWSTGSSIMPQKRNPDAAELVRAKPGRIIGSLTGLLTVVKGLPLAYSKDLQEDKAPVFQAIDDLELALLS-MAGMAGDLSFFPEALEEAAGEAYSDATDLapFRDAHHigSIVKLAEARGVPLAELSLAEMQSVEPAIDE-----------------------
    169 UniRef50_C6HWT1        Argininosuccinate lyase n=1...   303     1e-80  1  17.1%  14:474   5:458     -------------SKEIPSSKPWGGrtDKDVERFTES---ISFDGRLFREDIRGSRAHARMLARVGLLTPEELGQILQGLDRVEEEFSAGRVELRSDW---------EDIHMHVEKRLV---------HHAGAAGLKIHTARSRNDQVALDLRLFVRRAAEDLIDALDRLLRATLMKGYGYRDLILPAYTHTQQAQPVSGGYYFGAYAERLLRDRKRLRGVIDSAGLSPLGSGALAGTT------LPIDREFVASELGFSGV-TQNGLDTVGDRDFVADFLHALSLLMVHLSGWSEEWILWSTREFGMVRLP--DRLLTGSSMMPQKKNPDILELIRGKAGRVVGDYTGLLVLLKGLPLSYNRDLQEDKEALFDAVDTVAGSLL-MMRLAVEGMAFETARIEEILSKTELLATDivPFREAHavGRIVAHAAAKNLTLEALPDSDLALFFDRfsSTLSPAGSvgPAPETVLRRL----
    170 UniRef50_C1A4N7        Argininosuccinate lyase n=1...   303     1e-80  1  17.2%  20:478  16:465     -------------------HKLWGGRFAGGPslLDAINRSIGTDFRLWPHDVRLSQAWAAGLGHAGVLTQDESLALQQGLDRVAQRIADGAQPV----------ATDEDIHTMIDRLLHEEAG---------TVASKLHTGRSRNDQVATASRLWTMDACQKLDAAIRELQQALLTQAETLTDAILPAYTHLQRAQPVSGTHWLLSHFWPLDRDRTRLANAARGTATLPLGSGAIAGSA------FPIPRTLIKDTLGFAAIS-PNSIDATGDRDFVAETLFACTMTAVHCSRIAEDLIIYGSSEFGFVKF--GDGFSTGSSMMPQKRNPDVFELARGSGARVLGDLVSLLGTIKGLPSGYSKDLQDDKRALFNAVDLLFL-VLPAMAGAISELRFNRDRMRNAVsmATDLADYLVkfREAhaVGSLVRQAEEAGIEMTDIPLEAfaLFGDDARDALGAEASlgTGPNAVARQLEQAR
    171 UniRef50_A9A331        Argininosuccinate lyase n=3...   302     2e-80  1  15.9%  37:477  17:435     ------------------------------------YVSSIDDDAAITFYDIVGSQAHVLMLYQQKIITKSDAKKILSSLESLKDE-------------TFDSSSGAEDIHELIEALVIKRAG--------MSSGGKMHTARSRNDQVVLDIRMKIRDDINIICNCLLDTIEALVSVAKNHQKTIMPLYTHLQQAQAGLFSHYLLAHADVLSRDFQRLYGTFERINQSPLGAGPVGGTS------ISIDRRSTAKMLGFDDV-VENSIDATSTRDFVAEYVSMVSILMTNLSKIAEDFVIWSTSEFSFIE--LSDEFTSPSSVMPQKKNPDILELTRGKTSEVIGNLTAILTTVKGLASGYGRDLQQIKSSIWSTSKISISALLIF-KSMLLTLKVNEKQMKKVTESSNLIALDIapFRVTHkaGSLTQLAHLSKKPISKLTPSD--IKKSVADTKVDPKLVLesSITVVSSLKERK-
    172 UniRef50_A6V1S9        Probable lyase n=7 Tax=Pseu...   301     4e-80  1  16.8%  39:473  21:444     --------------------------------------AAIFSDANQVQKWLDVERALAATQAELGLIPHEAAQEIARVAR--------VERFDLAALGRESLETGHLLVPTIRA----------LARACEGGRGEYVHYGVTTQDILDTGLILQVKEAWGHALGLLHSIRGHLLALALRHRHTPMVARTHGQQALPTTFGYKVAVWVDEIDRHLARFDEARERVLVGNL-TGAVGTLAAFGAQGFEIQRRTLAR-LGLGAPLTS----WHSARDRVLEAAWLLVQVSLTLGRVATEVYHLQRSEIDELREPARP-GQVGSSTMPHKQNPSTVDLISALSRLVRSQMVALTDAAFQL-HERDGTTWRIEWAALPELFVYAGALLTRMEALleGLEVREERMRANLdlSERVMLALAGQFGKQSAHELLHesARQGVPFREALLAHPRlpAQTLEALLDPLGYVGLAADMVDLV-----
    173 UniRef50_C9RPR5        Argininosuccinate lyase n=1...   300     9e-80  1  17.6%  19:444  12:414     ------------------WTGRFASGMAQSMVDLSFS---LQFDAELIEEDIEGSIGHGKGLVESGVLSKADYKKICDGLKSILDDYHAGKNLWCD---------SDEDIHMAVERVLTERIGAL---------GKKIHTGRSRNDQVCTDFKLYMRHRAAEIRQLEIELMETVLDLSKKYFGKMMPGYTHLQQAQPIYFSHYLMSMFFAVSRDVKRLDNFLELHSQLPLGSGAMAGSA------FPYHRALVAEALGFKDVS-PNSIDAVSHRDMMLEFNADLAIIANTMSRYAEDFVNWSSSEFGYL--TLHDAFSSGSSMMPQKKNPDSMELIRGKSGRMLGNFTALYTLAKGAPLSYSRDLQEDKEPVFDSVHN-VKVILRVMKEALETARFNFETMHAKmdLADLLVEAGVPFRDAHhvGSLVGDAARAGKQFTELSDE----------------------------------
    174 UniRef50_Q9X0I0        Adenylosuccinate lyase n=11...   299     1e-79  1  16.0%  31:475   2:430     ------------------------------VERYSLSPMklWTEEAKYRRWLEVELAVTRAYEELGMIPKGVTERIRNNAKIDVELFKK------------IEEKTNHDVVAFVEGIGSMI----------GEDSRFFHYGLTSSDVLDTANSLALVEAGKILLESLKEFCDVLWEVANRYKHTPTIGRTHGVHAEPTSFGLKVLGWYSEMKRNVQRLERAIEEVSYGKI-SGAVGNYANVPPE----VEEKALSYLGLKPEPVSTQVVP---RDRHAFYLSTLAIVAAGIERIAVEIRHLQRTEVLEVEE-PFRKGQRGSSAMPHKKNPITCERLTGLS-RMMRAYVDPSLENIALWHERDISHSSVERYVFPDATQTLYYMIVTATNVVRNMKVNEERMKKNIDLTKGLVFslTRKEAYDIVQRNALKTWNSEKHFLEYLLEdkLVTKEELEELFDISYYLKHVDHIFERFEK---
    175 UniRef50_C3MRJ0        Adenylosuccinate lyase n=14...   299     1e-79  1  15.6%  18:478  24:460     -----------------PLEWRYGSNEMR----------KLFSRGEILKRRIQVEIALLKALSKYGLVKEEDIQKVEKA----------------------SLTIRPEEVDELESKIGHDVMAMVVLMAesGDSGRYVHFGATSYDIVDTAYALIFRDAIRLVKRKIMEILEIMISLAIKYKDLVMVGRTHGQHALPITLGFKIANYIYEFSRSLERLNEVEKRIVKGKI-AGAVGTMAAWGNIGLEI-EENIMKLLELRPHEISTQ---VAPRDAFAELTSDLAILASQCDRFALEVRELMRPEINEISEGV--EGRVGSSTMPQKENPVTSEKIGGLA-KVLRSLVVASLENIPLWHERDLTNSSSERIVISHEFLIIDEILDSMTNLLRNLRVNFENIEKNLNLTKGQIMAEskGMKRHEAHQYVnkVRQTGKTLLEVCLEdsYFSKQELENVFNPKNYLGSYDKLIERAIGYAK
    176 UniRef50_Q0W7A4        Argininosuccinate lyase n=8...   298     3e-79  1  18.6%  16:478   6:461     ---------------DILRRGRLAAEKKKEVGEFTAS---IPADRWLFPSDLLVDKAHTVMLARQGIIAKEDAAAILKALAAIEHEGVDAVNIP-----------AFEDVHMAIESKLIKAVGE--------NAGGRMHSGRSRNDEVATCIRISARKELLGLMADLQDLRSALLALAEEHKETLMPGFTHLQHAQPTTLAHHMLAHASSFGRDFERLADALKFVNISPLGSAAFAST------GYNLDRDLTAKLLGFD-RPMDNSMDGVSARDFILDLTSRMAIIEVNLSRLADELVLWSTSEFGFIE--LSDTYASTSSIMPQKKNPDVLELVRGRSGTVIGHMMAAFTIVKGLPYSYNSDLQEVTPQLLRAFEI-TRSSVRIMAGAIQTITVKKEEMRRKSTMGFTTATEIADTIVrrTAHGIVGRLAREGgsLADVDRaeMGLTEKMVEEAKDPWSNvgPALKTVEKKISTER
    177 UniRef50_UPI0001C3166B argininosuccinate lyase n=1...   298     3e-79  1  18.5%  34:476  12:443     ---------------------------------FQQLNASIGFDWRLGPYDVDLSRAHAKMLAAQGIIGQDDRDALLRALDSVEQELQDGSF---------PFEPDDEDIHMAIERRITQLAGRV---------GGKLHTARSRNDQVATDMALFTRAHAQAAQEAIRGLMRALVATAERHLDWRMPGYTHLQRAQPVYLSHHLLAYVWMLARDLEKFAAVEQATARLPLGAGALAGVN------FDTDRQLVARELGFAGV-AENSIDAVSNRDFVLDYLAAAATCGTHLSRLGAEIVLWSSSEFAFAE--VSDAWASGSSIMPQKKNPDAAELLRAKAPRIAGHFVALQGTMHALPLTYNKDMQEDKEHLFDAVDTL-ELCLAAAAGMIEGIAFDRERMAEAASDEFPAATDVapFREChvVAGLVKQAVDSGRTLTEliREQSELLDGEYYEVLRGERWLEsgGTSLRRVREQ--
    178 UniRef50_A9A3T9        Adenylosuccinate lyase n=3 ...   298     3e-79  1  15.8%  17:478   4:446     ----------------LPIdgRYGTKEM----------MEIFSEQNKVDYQLQIEGAAAISQSEIGMIPKTVGRKIFKTAN--------------------SGKITAKRIKQLEAKSDHdaLVESLSEKCTKDARPWIHYGLTSNDLVDTSNSMQMRDALLIIEPKVAKIASILAKKAVKHSKVPAVGRTHGQHASIISFGLKFANWAAEMAKHVERIEEIKKRILICKTL-GVVGTGSLMGAKSLEVQRRA-AKRLKLFPAEVTTQVVP---RERYAEYVFELALIGATLEKIAIEIRNLQRTEIGEVAEQ-FKKGQMGSSAVPVKRNPIKSERVSSLSKLV-RSQVALSFENIPLWHERDLSNSANERFVIPTVSILVDEMLETMTRIVSNLLVNEKRIVDNLYITKgvLEAlvpfVAYRDVQRVAFLANDKGMLYKDAIKNDkkLTDKEIDAIFSPEKHLGASPKIISNVNQSVQ
    179 UniRef50_D2BHS6        Adenylosuccinate lyase n=7 ...   297     6e-79  1  13.6%  39:473  11:427     --------------------------------------KKVWSDESKFAYWLDIEIAVCEAWAKMGAISREDITKIKLARLNFK------------------------RMEELLKETHHDMTAFLGSVAEsgEESRFIHMGMTSSDVMDTALSLQLVEASKILNNGVKDLINALAAKAMEYKYTVQVGRTHGVHAEPISFGLKLALWMEEMKRNRQRLAEATKAITVGKM-SGAVGTYATLSPE----IEEIACKKLGLSPASISNQVIQ---RDRHAQYMTTLAIIAGSLEKFATEIRALQKTECHE-AEEPFEKGQTGSSAMPHKKNPELCERICGIARIIRGYSVT-AMENQPLWHERDISHSSTERVIMPDGCLLIDYALHIFTNVIKGLNVFPEQMEKNLNLTGGlmLAlnKGLSRQQAYKMVQRNAmqGEdfMNLLKADAevTSAEIDELFDYKFYLRYIDDIFSRV-----
    180 UniRef50_Q1ER98        Argininosuccinate lyase n=1...   297     7e-79  1  15.1%  23:471  10:442     ----------------------YRSRLKGSleHVLAYLSSMDEDTSLLPYDIVGSEAHSIMLYEQGLINKDELARILEALESAKG---------ISADELRSMKERYEDVHEALEAYVIGKAG--------IDAGGKMHTARSRNDQVTLDLRMKVRDDITAIEYAILEVVDALLARAKECIDAVMPMYTHLQHAQIGSFSHYLLAYVDMLLRDVDRLESCYARVNLSPLGSSAIGGTS------LQVNRDRVANLLGFNGI-VENSIDATSSRDFLLEFCSCLCITMLDLSRMAEDMVLWSSSEFNYIE--LSDELASTSSVMPQKKNPCPLELMRARASTVLGLLASIMGIVRSLPSGYSRDLQESKRIAFD-VFKIVYESLLIMRQVVSGIIVKRKDMLNAAEKSYAiaEELVKRRghRLVGAIVAYANSHDKNLRDLSMDDLklDPFRIDK--DSMDMVEAISSIVR-------
    181 UniRef50_Q1DAL5        Adenylosuccinate lyase n=4 ...   296     9e-79  1  14.2%  40:461  12:411     ---------------------------------------SLWSDEARYSRWRDVELAALEGMVEAGLAPREALQD----CLARAGDFTPGDAAK---------------IEEIERTTKHDVIAFLTFMEERVGpaRWLHLGMTSSDVLDTSLALTLRDALDLILKDVDRVMAAVEKRAFEHKHTLQMGRSHGIHAEPITFGHKLAIWYDELRRARTRLEHARDVIAVGKI-SGAVGTFAHLP----PAVEEHVCRKLGLKPAPASSQVVQ---RDRHAEFFTALALLGSSIEKFAVEIRHLQRTEVRE-AEEPFTAGQKGSSAMPHKRNPILSENLTGLARLLRGYAVS-AMEDVALWHERDISHSSVERVIGPDATILADFMLIRFARLMEDLRVYPEQMKKNLdnSQRLLLELARkmDRQAAYVIVQRNaeEGLDFRQALLAD-----EDLRKMMTPEE-----------------
    182 UniRef50_D0U661        Argininosuccinate lyase n=1...   296     1e-78  1  17.6%  21:470   2:444     --------------------ALWGGRFTQGPEefALS-RSVHFDWRLAPYDLRSSKAHLAVLKKSGLIAATDADAIAAALNELSADVVLGSFVAID---------SDEDVHSALERGLTEKIGVL---------GGAIRAGRSRNDQVTTDLRLFSIDHMLEVAHLITLLQTAILEKASEYVNDPAPGFTHIQHAQPVSFGHELAKHAHAFARDLDRINDWLARTSVSSLGAGALAGSS------LALEPAFTAQNLGFDSSFA-NSIDAVSDRDYVAEALFICAMIGSHLSRIGEEWTLWASQEFAWAK--VADAYSTGSSIMPQKKNPDMAEIARGKSGRLVGNLMSVLTMLKGLPFAYNRDLQEDKEPLFDSIDTLLL-VLPAVTGMIATTDFDRDKMALAAPSGFSLATEVADyiAHEAAGKCVAMCESSDRQLHQLTDAEFLQIHPQLddVLTVHGAigTAPVLV--------
    183 UniRef50_B7LRV7        3-carboxy-cis,cis-muconate ...   294     3e-78  1  16.5%  42:478  18:445     -----------------------------------------FTDECLLQGMLDFEAALALAQARCGVIPPSA--------VAAIAAACRAENIDVQALGGDAALAGNLAIPLVKQLTAQV-------KKNNAAAARYVHWGATSQDVIDTGLILQLRQALQLTQQSVNQLLATFAEQVFRYQKTVMPGRTWMQQALPVTLGLKLAGTLDALLRWQVRLEELLPRVLVLQFGGAA-GTLASLKQDALP-VAAELAKVLGLTLPDLP----WHTQRDRLLEIAAWYAGTGATLAKFAQDFALLMQTEVAEVSE-PAVAGRGGSSAMPHKRNPVICASILTAAQRTPG-LMATLYASQLQQHERALGGWQAEWETLPELIMLTGNIIAQSQELVQGMQVYPQKMRENLDITHGLLmaLAEFIGKQDAHHLvrQAIEQQHALYDVLVNDTRItaTQIKNLLEPTAATGSAQVFIDRVLARYK
    184 UniRef50_Q1IIZ3        Argininosuccinate lyase n=1...   294     3e-78  1  14.2%  21:478   2:450     --------------------KMWSGRFSQSLdeFESWQRSLPFDKKLLRHEVAASGAHATALAKAGVLSSEELALIKSGLAQIARDGAPDADDP-----------SIEDVHHFVESRLIEIAG---------EVGRKLHTGRSRNEQIATDLRLYVREQIDETTLLIADVIAALIERAESVGEAAMPSYTHLQRAEPVLIAHWLLAYAEMFFRDITRLADCRKRANLCPLGSAAVAGT------FVALDRGYIATLLGFD-APTANSIDATSDRDFAIEFVQSLSVIGLHLSRMAEEMILFATTEFGFLQLP--EQFATGSSAMPQKKNPDSLELVRGKSAALLAHAMQLAVTLKALPLAYNKDMQETQQPVFASAEECI-AMLRITAGFLRAVKFNTAVMHTAASTGYMNAMAAapFRRAHeiGAAVKLAVEKHCELHDLSADdgIAADDSFYAALQLPAVlgTAPNQVSTALKAAK
    185 UniRef50_A7GVW1        Adenylosuccinate lyase n=27...   294     5e-78  1  15.7%  42:473  14:440     -----------------------------------------WSVQAKYDTWLEVELAAVKAWNKLGFITDADCEKICKNAK-----------------------FDVMRIDEIEKTTKHDVIAFLTSVSEsgEESRFVHYGMTSSDCIDTAAALQIKGSLELIIEDVQNLLSAVKSRAMEHKNTLMVGRSHGIHGEPITFGLVLAIWYDEIKRALKLITDAKEVASYGKL-SGAMGNLAHAPMEF----EELTCELLRLRPAPASNQVIQ---RDRYAHVISAIAILAATCEKIAIAIRHYQRTEVYE-AEEYFSPGQKGSSAMPHKRNPVLSENITGLCRML-RSYVTPALENVALWHERDISHSSVERFILPDAFVTADFMLARLANLIQNLVVYPENMMKNLNLTGGLvlEL-PKRgrEDAYKIvkKAIDEGGhlQNLLADEEllSEDEIKACFDYGYYTKNVDRIFGRV-----
    186 UniRef50_A5CSI8        Argininosuccinate lyase n=1...   293     1e-77  1  15.5%  21:477  16:463     --------------------ALWGGRFapSPELVALS-RSTHFDWQLAPYDIAGSRAHARALASAGYLSDAERQAMLQALDTLEDRVRSGALVASEA---------DEDVHGALERGLMDIAG--------TELGGKLRAGRSRNDQIATLVRMYLRDHAAVIHAMLVQLVDALAAQAEAAGGAIMPGRTHLQHAQPVLLAHHLLAHCWPLVRDLERLADWDARADVSPYGSGALAGST------LGLDAGAVARDLGFA-RSSENSIDGTAARDVVAEFAFVLAQVGIDLSRLSEEIILWNTREFGFV--TLSDSFSTGSSIMPQKKNPDIAELARGKSGRLIGNLSGLLATLKGLPLAYNRDLQEDKEPVFDSVQTL-EVLLPAFTGMIATLRFDTDRMAELAPQGFSLATDVAefRDAHEvgELVKAAESRGVGLEDLTDDDLrvSppEVREVLSIEGSvgAGGTARVRVDEQR-
    187 UniRef50_Q5HT21        Adenylosuccinate lyase n=22...   292     2e-77  1  16.2%  23:478  16:449     ----------------------WSTQEMRA----------IFCEQNRIQKWLDVEAALAKAQAKLKIIPKKAADEIAKKA--------HYKFMDMDFIFAEYKKTKHPLVPTV----------RGLEKACDDNLGEYVHFGVTTQDVIDTGLVLQFKEAMILVKSELKAIAKALAKLAKTHKNTAMMGRTLALQALPITFGHKVAIWLSELDRHFERILELEKRLYVGSI-VGAVGTKASLSDECNE-VEKLTLENLGLD----VPNISWQPARDRFIELGFVLGNINATFNKIAHEILILSHNEIDEVAE-PFGKGQVGSSTMPHKRNPAVSENAVTVSNAFKANL-AILSDIERHEHERDGQVWKMEWKLLPEMFLMLSVVLANMKFALSDLEVKKDKMLKNLnlAERVMFALSDHYGKQHAHEIVYEniEKQKTFKEVLLADKRVseKEIDALLDASTYVGYAPKLVDEFLAKIK
    188 UniRef50_Q6SPG4        AttA n=1 Tax=Photorhabdus t...   291     3e-77  1  15.7%  19:478   2:456     ------------------AEKLWGGRfdRSVLKYTLTTDI---DSRLIRYDIWGSMAHLAMLNNGEIVSKEAAGKIFSALLKLYESNERGTL---------TLDPELEDVHLNIESLVIREIG--------SEYGGRLHTARSRNDQVVTDTRMYLRVELLDIQKNLYSFVNTLLKLSDECTHKIAIGYTHLQPAQPISLAFWYSCYASMFLRDLARLESAFNVTNLNVLGACALAGTS------FPIDREITSKLLGFDRELM-HSLDATSSRDFVLQTASTFAILMSNFSRLAEEIVIWNSHEFGLLA--IDDTFATGSSIMPQKKNPVVAELVKGRVGRIYGVLMQLLTMVKGVTLGYNCDLQEDKPMLWDAIDIIKNTTSILHQH-IENSDYKSDRAEELCWKNFSTVTELapFREAHHlgLLTQKLSTEAMDMRnlAQQSIALSEKEIHDCVSPIKVMeaGSTGPDRVKEMVK
    189 UniRef50_Q5WHY3        Argininosuccinate lyase 1 n...   291     4e-77  1  15.5%  33:478  17:462     --------------------------------LFKPSIRSDLKHH--YSYLLKINSVHLFMLKSEGIISDEAASKIHSVLTHLQVTGKEA----------LSINPALEDLYFNVEAYIIEQTG--------PEIGGQMHTGRSRNDILATVTRMRIREEMLEIYELVCTLRRTLIDLATEHTSTLMTGYTHLQPAEPITFAHYLSALLHGFERDFTRLYNCYAHINKSPLGSCALASTT------FSINRKFTMELLGFA-DLLENSLDGIASRDYALEALSALSIFSNSLSRFAQDLYTWCSYEFGYLE--VGHSVAVISSIMPQKKNPVTLEHIKAKAGHIQGALVSSLSVLKNTLYSHSRDTSMESMKYTWEAINETKAAIRLMIKTLQTLTVHKDNMAATTRQNFSTVTELasFraHHIVAEIVNETLNQgrAIKQVTAKTVSVTKEFVEQALDPERNigSAPVEVARQLQQLE
    190 UniRef50_Q024Z9        Adenylosuccinate lyase n=59...   291     4e-77  1  16.7%  40:476  12:436     ---------------------------------------RIWSDQNKFQQWLEVELAASEALAELGVVPAGAARLLREHA---------------GFDVARIHEIEKEVKHDVIAFTT--AVAETMKARGHAEASRWFHYGLTSNDVVDTAQALCLQQASAILLKDLAGLREVLKRRALEFQHTVQIGRTHGVHAEPITFGLKLAIWYEEAGRNLARLSAAAEDVRVGKT-SGAVGTFGHIDPET----EEMICARLNLKPAPVASQVIQ---RDRHANFVAALALTTALCEKIALEVRHLQRTEVRE-AEEYFAKGQKGSSAMPHKRNPVTCEQICGLARVVRGN-VTPALEDVALWHERDISHSSVERVILPDSTILTDYLLEKTTKLVDQLLVYPERMRRNLDLTRGLVFSgaAGMLREQAYRLVqrAWEEEGDFRAAIEADPdlTRDKIAEAFSLERQLRNIDKIFTRVFGR--
    191 UniRef50_Q2FR16        Argininosuccinate lyase n=4...   291     5e-77  1  16.3%  32:478  17:460     -------------------------------EDIESLLSSMEADRNIASSDVLVDMAHLVMLTRQQIVHEDHAKTLMKELLCMYESGVPAEAFD----------PSYEDIHAGIETILTRKTGG--------DVGGRLHIGRSRNDEVATCLRIRTRDIILDQLEALTRLRSVLLSVAADHITTVMPGFTHLQHAQPVTLAHHLLAYEQMFSRDFDRLFDALRRVNCSPLGSAALAST------GYPLDRPFTADLLGFDRILV-NSMDAVASRDFAEETLACDTMLLTNISRFCEELIIWSSAFVQFVN--LDDRYCSTSSIMPQKKNPDVAEILRSRTGTILGSFVSAITIVKGLPMAYNRDLQDLNPHLWRGITGVRRDI-DLLAGMVESATFNRERMAEEAGRGGTTTTELADTLVRetAHHIVGKAVKDgeEFYGKTLSSLGVTQKNIDSALSVSTSlgPAPDAvdALAERRK
    192 UniRef50_Q024T3        Argininosuccinate lyase n=1...   290     6e-77  1  13.2%  21:461   2:428     --------------------KLWGGRFESGpeVFERFSGSLDFDRRLIDCDIRGSQAFARALENVGILTATERAQIVEAFDSIRAESLSPAFY---------EGATDEDVHTLVIRKLKERAGAV---------ADKIHTGRSRNEQVSLDTRMWLREESTDLQAQLFAVMGRLLDLAEMYPHAIIPGYTHMRRAQAVLWPHYLLAYFEMFLRDWHRFGDARRRANVLPLGSGALAGS------GFPLDREAMAQNLGFEGI-TQNSMDVSGDRDFALDFLYACTVTMIHLSRLAEDWILYSSEEFGWLE--LGDGVTSGSSLMPQKKNPDSLELIRGKSGRVVGCLTSLLVTMKGLPMTYNRDMQEDKIPIFDAADQLSGSLL-MTSAVIESTRLNPARPAAAAEESWVVATDLAEALArhQAHQIVgeSVRANKKPSDWTAEEMHAFAPefAALLNPAE-----------------
    193 UniRef50_Q4FNK3        Argininosuccinate lyase n=3...   290     7e-77  1  15.1%  21:431   9:402     --------------------AIWGSRIKkaSTLFQKVGNSIDIDKKLFQEDILGSIAHVEMLFRQKIISFKIKNKIIFGLNKIEKEILKNKFE---------YNKKYEDIHMNIEKRLFQIIG---------EEAGYVHTARSRNDQVITDFKMWTTSATKEINKNLDNIIKTILKISEKNIETIMPGFTHLKNAQAVSFAHYLMSYVEMFNRDKKRFTYNLESLSENPLGVAALTGTS------FNIDRNFTSKKLGFK-RPTNNSIDTVADRDFVLDFLYSASVCSMHISRIAEELIIWNSDGFNLI--TLSDKVVTGSSIMPQKKNPDLLEYLRGKTGTVYGNLFSMLTILKGLPISYFKDLQDDKEILFKSNEILNNSI-AILNEVLKNLKPNKQQMLDLANSGYITATDLapFraYQTTASIVNYA-----------------------------------------------
    194 UniRef50_D2QNX9        3-carboxy-cis,cis-muconate ...   290     9e-77  1  17.6%  39:476  14:434     --------------------------------------QSLLSEETTVAHMLRFEAALATAQANNGLIPTPSAERIAACCTVELLDWERLKKDI--ALSGNAAIPLVKQLTEVVRKR-------------DEEAAGFVHLGATSQDVVDTATVLTIKSVLDWLDDKLSALANRLIALTQAHRQTVMIGRTLLQQAKPITFGLKTALWLDGLGRSQQRLAACRQRVLVLQL-AGAVGSRNASIPD---AVHQETANLLGL-----ESSVSWHTQRDNIAELAAVMGILSGSLAKIANDVMLLMQTEIAEVLEGKA-AGKGSSSTMPHKRNPVTTTAILANANRVP-NLVATMLSAMPQEHERSAGRWHSEWDVLTDIMQLTAGSVERSLELLDNLEVDSQRMRQNLELTNGLilALAPKLGKATAHELVEkaIAEQKHLKDVLREQA-IDVADLDKLFKPENSLGQALEIIDFILHR--
    195 UniRef50_B8GH19        Argininosuccinate lyase n=1...   289     1e-76  1  18.9%  44:478  29:458     -------------------------------------------DHWIAEADVLVDIAHLLMLYRQGIIEPEPAAAVMDVLLRFSADGVPEEAFDEQ----------FEDIHAGIESLLIAEVG--------IEQGGRLHIGRSRNDEVATCLRLRLCEELLVIGDAVNGLCEVLVSLAGEHTHSVMPGFTHLQHAQPTTLAHHLLSYAQAFSRDLERLLSTYQRVNRSPLGAAAFAST------GYPIDREFTATMLGFSGVL-ENSMDAVSTRDFALEALADCAILMVNASRCCEELILWSSSLVRFV--QLDDAYCSTSSIMPQKKNPDTLEIMRARAGSVIGASTAALSIVKALPMSYNRDLQQLTPHLWEGIGD-AGASIRILAGALSTATFNTERMETEAGRGFSTATELADMMVRetAHHIVGRAVRSgvSLKKAATGESilTEEKVQAALDPVHGigPAVASVSTAIETLQ
    196 UniRef50_A7H771        Argininosuccinate lyase n=4...   289     1e-76  1  16.5%  40:476  36:464     ---------------------------------------SIQDDGALYAEDIRGSQAHVTMLAEQGIVPKASARRIVAALDQVRAEFAAGKIRLDPAL---------EDVHTHVERRLGELVGA---------DAGYLHAGRSRNDQVALDERLFIVAACERCDAALGRLQRALVARAREHEKTILPGYTHLQRAQPVSLAHHLLAHVEAFARDRDRLADVRRRAAVSPLGSGALAGTT------LPLDREATAKALGLAGV-TQNSLDAVSDRDSAIELLFACALAAVHLSRVGEEIVLWTTKEFGFM--TLADAFATGSSLMPQKKNPDVGELARGRAGRAIGDLVALLAIVKSLPLSYNRDMQEDKRPLIGGPDALVLTADAV-GGAIETATFHADRMEEALGSGEALATdgVPFREAHEagKAAAFSSAEGRPLAKLTADEwpAFQKDVLRCFDARKSlaPGPRQVARQLAR--
    197 UniRef50_Q0SJY5        Probable adenylosuccinate l...   288     3e-76  1  16.6%  38:476  54:480     -------------------------------------QRAIFDGPQRLQGWLDVERALAQTQAELGIIPAEAAQRISAHCQS--------DLFDINKLRQHVNATQHPIVPMVNA----------LEKLVGTEFGQFVHYGATSQDIMDSGQALQLRQSLQGIERDVAAATKAAASLALKHRNTTQVGRTHGQHAVPISFGLKAATWVDELQRLQTRIAESRDRILTVQIFGAA-GSMAGYGDRAFE-VKAGVASRLGL----TEPVAPWHATRDRIAELGSLMALLAGVSERIAAEVIRLQSTEFGELVEPLQPGH-IGSSTMPQKRNPHLSEGIVAKA-RIAQSLSAGLLRNGAHQHERDMGAWAVEWLTVPELMVGSGAMAADLNHLLEGLQVNAECMRRNVgnAESLMMILDSSIGRDHAheLTRSADLQNLNFSEVATADErlSQDQIMKALDPAQYLGFAPEVADRVSRA--
    198 UniRef50_C0CW77        Putative uncharacterized pr...   287     5e-76  1  17.1%   7:473   1:435     ------MEEEYYGSRDVQEDVFGGANT--------------------IQKMMDVEAALAWAECEVGLVPEQYAGEIQKKCSVELLDEAVYA--------------------EARRTTGHPLMGMLRAYkcSKEAGEYIHYGATTQDISDTALILQLREAWDIVEDKTRRLRKILAGKAREYRSLVMIGRTNDQQAMPITLGFKISTWIDELDRCLERMAQGRERIFVGQF-AGAVGTMASLEQNG-PRVQKLLFERLNL----AAPKISWFATRDRLAEFTFDLAMICGAVGRMGNEVYNEQRSEVNELAEGYA-QGKVGSSTMPHKRNPFLPGRLAGR-GRIAGTLVMRAMQCLENTNERDCRTLCIEPYHLKEICCLADGTLDIALELFGQMEVHEDQIGHNLEisEALMMRLAEVYGRMEAHELVYeaIGQKRQLKELALADSrlTEEELENLMRPEHYTGLAEHFVDQV-----
    199 UniRef50_D1NTX5        Argininosuccinate lyase n=2...   287     5e-76  1  15.5%  21:472  13:450     --------------------ALWGGRFspSPELARLSKSTQF-DWRLADDDIAGSRAHARALGHAGLLTQDELARMEAALDELQRQVDSGEFAPIEDDEDEAT-----------------ALERGLLAITGDELGGKLRAGRSRNDQIATLIRMWMRRKARVIASDVLDLCDALMAQANAAGKTVMPGRTHMQHAQPVLLAHQLMAHVWPLLRDVSRLRDWDARCDASPYGSGALAG------NTLGLDPTMVARELGFSTV-TSNSIDGTAARDLVAEFAFINAMIGVDLSRLSEEIIIWNTQEFAFV--TLHDSYSTGSSIMPQKKNPDIAELARGKAGRLIGDLTGLMATLKGLPTAYARDLQEDKEAVFDQVDTL-EVVLPAFTGMVRTMQFDHERLEEQAPTGFALATDivPFRHAHElgACVKIAEGRGQELWDLTDDDYivFADFldIAVQVRDVLSTAGSVAAR------
    200 UniRef50_C9QH62        Aspartate ammonia-lyase n=1...   287     5e-76  1  29.0%   4:444   2:442     ---QYRIEVDNIGEVRIPVLLPYGAQTQRALNLYPVDNQklGDYASLINAVLRIKLASARVNREIGEMDPVLSLNVENTCQSILENYQR-ELFPVHAFHGGGGISVNMNVNEVVANIvhSYYAQPYGTYSPAHPNDAINMNHSTSDCLQTASHLAAIEALDRLDTTTERLIYALEYLMANHSDSSKLARTCMQDAVTIEFKQFWGGYLASLRTYQMHLKACRNDLQAVNLSGNIIGRSGDCSTAYAERCIAVLSDVIGIELRKSDNLFQSSQSFDAQIHCVSQVENLAGFIIKIAKDLRLMSSGPEGGLSEITLPAVQAGSSAMPGKVNPTIPEFAIQSAMQAQGHCYSSKQAHIHGELDYNPWGMLLITNLLDAIDHLEKGISVLTEKCIFGIEVNSETQSRNESALVPLVVRVKSKIGYKATLDHVKEA-KNSTELKETLQE----------------------------------
    201 UniRef50_C7M0R6        Argininosuccinate lyase n=1...   287     7e-76  1  16.3%  19:454   4:417     ------------------WQHRMGAPPADALLSFTES---LSIDERLWREDLEGSRAHVEGLHHAGLLDDDELETLLGALRAVEAELGEGTFVVV---------PSDEDIHTAIERRVTELAG---------DVGAKLHTGRSRNDQVATDLRLWARDALAEVAGGLIGFADVLRELAESAGSAVMPGYTHLQRAQPIPVAQWLLAHAWAVERDIARVLDALVRMDVSPLGAGALAGST------LPLDPPWVAARLGFSRSFA-NSVDAVSDRDFVAEGIFAITMAGVHLSRLAEEIVLFTTEEFRFIR--LDDAYATGSSMLPQKKNPDIAELSRAKAGRYIGDLVTILTVLKGLPLTYNRDLQEDKQPLFDAVDQFRLE-LSAMQGLLATMTFDFDAMRQAASSAydVAEYLvpFRRAHAVAalVRDSLERHVALAELVAAHPQLGEEAVR------------------------
    202 UniRef50_C8WK16        Adenylosuccinate lyase n=12...   287     8e-76  1  18.7%  40:477  26:460     ---------------------------------------AIWELENKFNIWKEIEVLACEAQAELGkiTKEEAAWIRAHADFTVERID---------------EIEKVTNHDVIAFTTNMAEYIDADVPEGTEpsRWVHYGMTSSDLGDTALSYQITQAIDIILEDIKQLGETCKRRAFEFQETLCVGRTHGIHAEPMTFGMKFGSWAWALKRAQTRMEEARKVAATGAI-SGAVGTYSSID----PFVEQYVCERLGLAADPLSTQVLA---RDRHAQVMAGLAVTASTLESIAMQVRLLQQSDVIE-AEEPFAKGQKGSSAMPHKRNPITAERVCGLARTVKSNAQ-VAFDNVALWYERDISHSGAERVALADSFIALDYMFGKMQWMLDGLQTYPAKMEHNLWRTKGLilALVdgISREDAYVIVQRNAMkgPTYRENLEADPelSAEVLDEIFDPWDFLTRKDVVFDRLKELE-
    203 UniRef50_B3T6G2        Putative Lyase n=2 Tax=root...   286     1e-75  1  15.0%  18:478   5:445     -----------------PLDYRYGRDEAK----------HIWSREGRHARHLEVERALVWAHCQLGRVSAEDYDKIADIADP--------------------GIVTADRVDEIEQETRHDIMALTKAMAEAAGEAGwiHLGATSNDIVDSAVALQIKDSIAMQRDMLKQLITTMCDIAERERDTVMLGRTHGQAAVPITFGLKVAVWVDEFARHLERLDELATRATTGKFL-GAVGTGAAQGEDAFELQ-DLIMTELGLGIPVATTQVVG---RDRYIEWVGWMANVATSVEKVLQEVRNLQRSEIAEVAEAFDAEKQVGSSTMAHKRNPITSENACGLA-RIVRAMIVPSYENALLWHERDLANSSAERFTLSHSMILLDDILAKSDWVLSNLVVDSQRMRANIDAQQGLVmaLVDkvPREDAHEILRRASTegVNLEEVCSKIPLISdaELRSLFEPEGYLGHSGRIVDMAVSKAR
    204 UniRef50_Q1LG43        3-carboxy-cis,cis-muconate ...   286     1e-75  1  16.9%  40:478  48:482     ---------------------------------------EVFSDTGTVRRMLDAEAALARAEAQCGVIPATAAAVITEVCGRV-------DVIDLEALAQAAVSAGNLAIPFVKQLTAAV-------TQRDADAGRYVHWGATSQDIIDTALVLQLRDALREIVVDLLRAGDACATLAATHRATPMVARTWLQHALPTTFGCKAGGWLDALRRDLTRLDHVGAQVRVIQFGGAA-GTLASLGDDAPAVAARFAAEL-----QLDVPALPWHAHRDRLVEVATALGMLTGTLGKMARDVSLMMQTEVGEVAEPSGP-GRGGSSTMPHKRNPVGCAAVLTAATRVPP-LVATMLAGMTQEHERALGGWQAEWDTLPQIVTLAAGALRQMADVASGLEVDEARMRANLDITHGlmLELGRRIGRLQAHHLVEQASRraRTLAEDANHAGLLDDAALDRLSDPAQYAGQSERFTDAAVAAWQ
    205 UniRef50_B0S952        Adenylosuccinate lyase n=13...   286     1e-75  1  16.4%  40:473  12:430     ---------------------------------------AIWELENKFKIWTDIEIYACEARANRGEVPKEDLETIKQKAKFNVDE-----------------------ILEIESKVHHDVIAYLTNLNSYIGPAghVHFGLTSSDVGDTALCVQMVQAMDLLIQRTETLLETTKQKAKEYKDLPCIGRSHGIHAEPMTLGLKFALFFAEMTRNLERMKDAREQVAVGKL-SGAVGTYSNIDLE----IEEYVLNKLGLKVDPIATQVI---SRDRHAFYMSVLGVVAASLDRMATEIRLLQKTEGREVEE-PFAKGQKGSSAMPHKRNPVVCERISGIS-RVIRSNVNVGLQNVGLWHERDISHSSAERIVLPDSTIALDYILEKMNFVLKGLHVYPDATERTLNVTRGLilWLIEkiTREDAYLIVQENAmqSKNLRDLLKQDPrlKDSDLDEIFQIKPYLERIPLIFKRL-----
    206 UniRef50_C4KY42        Argininosuccinate lyase n=1...   286     1e-75  1  17.0%  18:463   8:434     -----------------PWAGRFSQTMTDSLVAFNTS---LPLETRLFEADIDGTAAHVEMLHATGLLETAEHEALARALDEIRAAWRAGEIRLSPAL---------EDIHMNLETLLVDKLG---------ELGKKTHTARSRNDQQASAQRLYFMRSTRELVDAIDALQRAILEHGERHDALVMPSYTHLQRAEFTYYAHWLATYVVMLERDRSRFVDALARADQCPLGACASTGTS------LPIDRRRSASRLGFR-EPTLHSIDSVSDRDYLVEFCSHAANLMIHLSRLSEELISFTSQEFGFIA--LADGYCTGSSIMPQKKNPDVPELVRGKAASVIGNAMSLMALLKALPLGYNKDLQEDKTAWFAALDNCM-SSLAILTELVRTMAPVPDRMRQATLGGHIIATEYapFREAHrvGELVKTADARGVDVSALpaEASPLFGDDIGR-VTVEDMV---------------
    207 UniRef50_C6I121        Adenylosuccinate lyase n=1 ...   286     2e-75  1  13.6%  41:474  13:432     ----------------------------------------LFETEHRLKTWLSVERAVVSTLARHGKVDPEGARAVAETAVRI--------------DIPRMEAIEAETRHDVIAFLTMV------SEQLPEKGRAVLHFGMTSTDLVDTAQNLLVRDALHIVADELRRFVGILREKALLYRTTLMVGRSHGIHGEPIVFGLKFLSWFAEFSRHAERLSRVRETMAVGKL-SGAMGTAVNID----PALEEEILGRLGLAVEPVATQVV---SRDRHAELFSVLAGIGSSLERVAVEIRHLQRTEVGE-AEEPFRAGQKGSSAMPHKRNPVGSENITGLA-RLLRSYSVAALENVALWHERDISHSSVERVILPDAFCLIDYMLDRMGTILRDLVVYPERMKRNLEASGGLvlELVdgLPREEAYRIVQDAAmeGGLFRERLVAHPDFPKGEidRAFDPLRFTHNVSGIYRRVL----
    208 UniRef50_A7IQF6        Fumarate lyase n=3 Tax=Xant...   283     1e-74  1  14.8%  39:478  21:451     --------------------------------------QALFDDAPRTRRWLDLLGTLAEVEGEFGLIPETSAAAIVAACRDVVLDDDFFARFAAGYRATGHSTAGLIDV---------------IRQRYPESVSEWFYFGATVQDITDSWLMLVLGEARALILADLDRSIAAATALCRAHRDTVMVGRTHGQQGLPITFGFKVAGWLAELRRHRQRFEEIAGRMGIGQLCGG-VGSLSALGRHGLEVQRA-FCERIGLRPPLTS----WTASRDVLVEWAQLLTLVAGTADRIGHEVYSLQRDEVGEVREGAAGE-QIGSITMPHKRNPEIAEHL-GTLSRVVRANTSVLAESLPHDHERDGRSWKLEWHAVPELTMAAGKAVRLLGQMLSNLEVRADRMHANLEasEGLMLALACKLGKQTAHRLVHQAaqEGQAFREVVGHDPvlTGADIERIFNAGLQTAQCQALVDRVLAGSE
    209 UniRef50_Q5SI61        Adenylosuccinate lyase n=4 ...   282     2e-74  1  16.5%  39:463  11:424     --------------------------------------ARLWSEESRYRMWARVEAYALEAWEALGEVPKGLSARLLAKLEEKPLDGAFAR-----------------RVAELEAVTRHDLVAFTRALAedEEVGRYLHLGLTSSDIVDTAQNALLVEALGLVLEELKGVEEALKALALRHKHTPAIARTHGVHAEPTSFGLRFLSFLAAFQRDEERLKRARETIGV-AMLSGSVGNYAHVPPE----VEAHVASRLGLRPEPLSTQVVP---RDRHAEVMAALAILGGNIERVAVELRHLQRTEVLEAQE-PFHEGQTGSSSMPHKKNPVGLENLTGVARLLRGYL-FPALEDIALWHERDISHSSVERVILPDATTLAHYALRRLKGILEGLEVFEENLARNLDLTRGLVYsiARGLSRNKAYALVqrSWKEGKSFLELLEADppLKGKELRALFDPKPFL---------------
    210 UniRef50_C1F4E8        Argininosuccinate lyase n=1...   282     2e-74  1  16.4%  21:478   2:458     --------------------KMWSGRFREPLdaFDHWQRSLQFDWQLLPEEVAASKAHALALEAAGVLTAGEREALHNALDLVTSRFHAPDG---SGPSWVMSNQEAEDIHHFVELQLVATVG---------DLGLKLHTGRSRNEQIATDLRLFVRSRAQMLQAYLGTWAEILVARAQQMGNAAMPAYTHLQRAEPVLVAHWLLAYAEMLLRDASRLEDCVRRLNYCPLGSGAVAG------ATLALDRGIASQALNFA-APTANSMDATSDRDFVLEFLQALTGIALHASRFAEEITLYATAEFGFVDLP--EAYSTGSSAMPQKKNPDLTELVRAKVGRINGAAQAVTLLLKGLPLAYNKDMQETQEPLF-QATIATHQMLHLLAKFTHALQFRTDHMQAACenAMAAATYLvpFRKAHevGHAVRLGLDKGCELAGLSLDELrlSPEflESTLDCHDVlgTARAQVQASLEAMQ
    211 UniRef50_Q1MPM6        Adenylosuccinate lyase n=7 ...   282     2e-74  1  16.5%  40:463  12:418     ---------------------------------------RIWTLNNRYQTWLRVELAVCLAWNKLGVISDDAFKTI----------------------QERAVIDVN-RILEIESITHHDVIAFLTALEEQIGpaRFIHLGCTSSDIVDTATSLLLIEAGELILKGFDKLLTSIESLALKHQGLLCMGRTHGVHAEPTTFALKFANFFAEIQRDKERFVQAFNGIHVGKF-SGAVGTYTFLTPE----VETIACDILGLKPDTISTQVIQ---RDRHAEYFTALAITAGSIERLCVELRHLQRTEVREVEE-GFQKGQKGSSAMPHKKNPISAENMTGLSRLIRGNVLA-ALENQALWHERDISHSSVERVIMPDTTILMDYIFHRLSGILDELIVLPENIECNMQASFGllNALIegMGRQEAYVSVQrsWETKQPFQEVIMDdsCLGQEMLEKLFDTSFYL---------------
    212 UniRef50_C1XI32        Adenylosuccinate lyase n=3 ...   282     2e-74  1  14.6%  39:463  11:429     --------------------------------------RALWSEARKYQAWAEVEILVMEAWESLGQVPIGTAKQLREALQKKPLDVSFA---------RRVEEIEAETRHDIVAFTRALTEWVEDAQGSSPEVARWLHLGLTSTDVVDTAQNVLLDEALGLIEQELDKVLTALKHLAVRYKHLPAVGRTHGVHAEPTSFGLRFLAFYAALLRDRERLGRAREGIRV-AMISGSVGNYAHVE----PAVEAWVARKLGFQIEPASSQVVP---RDRHAELMGALAILGANLERVAVELRHLQRTEVLETQE-PFSYKQTGSSSMPHKKNPVALENISGLARLLRSNLQAEL-ENVALWHERDISHSSVERVILPDTTTLAHYMLRRLGRVLEGLVVFEENIQRNLERTRGLvlLIEAGLDRTAAYEIVqrSWAAGQDFRALLEADppLKGGALAQAFDPGYFL---------------
    213 UniRef50_O29379        Argininosuccinate lyase n=2...   281     5e-74  1  17.8%  40:478  21:446     ---------------------------------------SIEHDKNIFLYDILVDVAHVLTLKKGGYLSEEEAKEIILALKKVKDSGFREDWP-------------YEDVHEAIEAEVTKI----------TPHGAKMHTGRSRNDEVATCLRMFARDHLLNLAEAILNALDVLIKKAEK-SHFLMPGFTHLQYAQPTRLSHHLLAYHDMLSRDFERAIEAFRRVNKSPLGSAAFAST------GYSLDRVYAARLLGFDGV-VEHSEDAVASRDFVIESIFVAAEAMLSISRIAEEIVLFSS-EFGFITLP--DEFSSTSSIMPQKKNPDIAELLRANAGKIAGNLTSAMMIYKATPFSYNRDFQEMN-PLLYESLKRTHLAVEVFASMMGKIKFNPEITERKASKGFATATElvPFRMAHrvGRLAAKELetASDVNSAAKELGvvRDEDVLEALDVEKVvgTSKAEVERMIKARK
    214 UniRef50_Q11IU4        Adenylosuccinate lyase n=24...   280     7e-74  1  16.0%  40:477  12:435     ---------------------------------------SIWSPETRFRIWFEIEAHAADAMAKLGIVPQEAARTIWEK--------------------GGNATFDIDRIDEIERETKHDVIAFLTHLSEIVGpaRFVHQGMTSSDVLDTCLNVQLVRASDILLDDLDRLLEVLKKRAFEHKDTVTIGRSHGIHAEPTTFGIKLAQAYAEFSRCRERLEHAREEVATCAI-SGAVGTFANID----PRVEEHVAEKMGLKPEPVSTQVIP---RDRHAMFFATLAVIASSIERLATEIRHLQRTEVLE-AEEYFSPGQKGSSAMPHKRNPVLSENLTGLARMV-RSYAMPAMENVALWHERDISHSSVERMIGPDATVTLDFALVRLTGLMEKLVVYPENMLRNLDRFRGLvlALTqgVSREDAYRLVQrvWEHGADFQQELLADKdlSEAEIREKFDLGYHTKHVDTIFKRVFGKA-
    215 UniRef50_Q6MLQ8        PurB protein n=1 Tax=Bdello...   279     1e-73  1  16.5%  41:458   4:403     ----------------------------------------LWDADHKFGKMMEVEIAVAQVQSQLGIIPKNAAKIIAQKAR-----------------------FNVKRISEIERETKHDVIAFVSNLAENVGpgKFIHYGMTSSDVLDTAFSLQVREAGVVLMKSIVALEKSLKTLVTKHAETLCAGRTHGMFAEPTTFGFKMAGFLAEAQRNKKRVKAALDNMMICKL-SGAVGTYSSQ----APKIESLVAKKLKLKTETIATQVIP---RDRHAEMLSALALFGTGLERLAVELRHLQRSDVAEVTE-GFTKGQKGSSAMPHKKNPISAENITGLSRLLRGYAIAG-FENVALWHERDISHSSVERVVFPDAFIVADYACNRMSILLDGLDVNKKRMMDNIESSQglLALIQKGMIREEAYALVQrsLSYGEHLKDKLLVdkLLKPKEIDEIFT--------------------
    216 UniRef50_Q2H905        Putative uncharacterized pr...   279     2e-73  1  14.0%  22:465  14:412     ---------------------LWGGRFTGAIdlMHKYNASIRYDQALYKEDILGSVAFARANWKAGIISEDEFQAIERGLLQVMEEWKQGTFAIM---------PNDEDIHTANERRLGEVIGK--------DIAGKLHTGRSRNEQVVCDMRMWLRDRIREIDSQLVAFLKVIITRAESEIDYIMPGYTHLQRAQPVRWSQWLMSHAAAFKQDLERLRQVFERVNLSPLGCGALAG------NPFRIDRNAIAEELGFSGITL-NSMNTSADRDFLLDFLVWNSIFTNHISRWAEDLVIYSTSEFSFVR--LADAYSTGSSLMPNKHNADSLELLRGKSG-----------------------------PCFRSNGWVNDGI---ANGVIATLKVRPERMAAALDKT-MLATDIapFREAHHigRVVAQSEQQEISMDKLTLEQLQAIdaDIAEAFEYETSVEA-------------
    217 UniRef50_Q9ZKA2        Adenylosuccinate lyase n=23...   279     2e-73  1  16.6%  39:473  11:438     --------------------------------------KALWNEQTKFETYLEVEKAVVRAWNKLGQIQDSDCEKICLKAAFNL-----------------------ERIKEIEKTTKHDLIAFTTCVAEsgEESRFFHYGITSSDCIDTAMALLMTKSLKLIQKGVKNLYETLKNRALEHQDTLMVGRSHGVFGEPITFGLVLALFADEIKRHLKALDLTMEFISVGAI-SGAMGNFAHAPLE----LEELACGFLGLKTANISNQVIQ---RDRYARLACDLALLASSCEKIAVNIRHLQRSEVYEVEEA-FSAGQKGSSAMPHKRNPILSENITGLC-RVIRSFTTPMLENVALWHERDMSHSSVERFALPDLFITSDFMLSRLNSVIENLVVYPKNMLKNLALSGGLvlElkKGLSREESYSIVQENAmeNLFLNALLNDekYLNESEIRACFDYSYYTKNVGAIFKRV-----
    218 UniRef50_A8IK84        Argininosuccinate lyase n=4...   279     2e-73  1  19.4%  26:478  19:471     -------------------------ETAQEICDF-IYLPRLADFARGFPYLTAINQAHILMLDAQALIPSDAAKTLAEALLQMEENGPSAIALDPQR----------EDAYFNYEAHLIGKVG--------LDIGGRAHTARSRNDILATMDRMRCRDLVIALLDALAELRQTAAEQAARYVDVVMPGYTHLQPAQPMTYGFYLAGVAEALERDAERLAGAYGRVDRCPLGAGAFAGT------PYGIDRSETARLLGFPAVVDST-LDAVASRDFIFEVLGSLSILAATWSRIAQDYFLWSTDEFRFIEFP--DSVAGTSSIMPQKKNPIVLEFLKGKAGHIIGHYAGAVSILRATNFTHSGDANRESISFFWGAADDCLTSLKLLRLIIRTASPRREVMLKRARENFSSATDLADAiaHHIVGAVVRDALDHDLTADRISLdeIALSEEDVHASLDPRISvgPAEEGVRMVLGKVQ
    219 UniRef50_D2RAR8        Argininosuccinate lyase n=1...   278     2e-73  1  15.1%  21:476  25:476     --------------------ALWGGRFSSGPseLTKLSKSTQFDWRLADDDIAGSRAHAHALHRAGLLNEKEYADLSCALDELQKRVDDETFAPIE---------EDEDEATALERGLLEIAGN--------ELGGKLRAGRSRNDQIAALIRMFLRRHARVIASLLLSVCQALLNQSKNAKDAVMPGRTHMQHAQPILLAHQLMAHVWPLLRDVNRFIDWDLRADESPYGAGALAG------NTLGLNPEEVAKELGFSKV-CANSIDATASRDLVAEFSFIAAMIGVDISRLSEEIIIWNTQEFAFVR--LDDAYSTGSSIMPQKKNPDIAELARGKAGRLIGDLTGLMATLKGLPTAYARDLQEDKEAVFDQIDTL-EVLLPAFAGMVETMKFDLNRLYEQSSTGFALATDivPFRNAHTLSGlvKRAEGIGGDLADLSDDdgFVDSAeiRTILTSAGSvgRGGTAFARVKEQ--
    220 UniRef50_Q5U9J2        Fumarate lyase n=2 Tax=Noca...   278     3e-73  1  16.9%  21:475  13:445     --------------------HLWGTDELR----------RLFDDEGRIQSWLEILAALAEAQAEFGIVPEDAARSIRENADVRRLDLVRVGELTRSTGHSTLG------------------LIRCFQEILPSSAREWVYYGATVQDVSDTWTSIVLQHVALVLDRDLARAERAARRLAETYADTVMCGRTHGQPGLPITFGFKAAVWASEVARHRERVAQGAARWGVAQLG-GALGTMEFWGEQALPLL-DSFASRLGLKAPD----IAWLTSRDRIAEFVGLLGMVTATLGKIGQEVYQLQRPELGEVRE-GLHRGVVGSITMPHKVNPEISEHLVTLA-RIVRSKVGPALEAMLHEHERDGRAWKAEWIFLPEACILTGATLSMSCQLLEELEIDEDRMMANLemSEPVMRELSPLLGKHVAHELVhrGREQGVGFEEVLLadGLLSADEIRKALDPVAAVGSAPEFVRRVLA---
    221 UniRef50_Q13PC6        Putative lyase n=1 Tax=Burk...   278     3e-73  1  15.5%  39:476  19:442     --------------------------------------RTIFSDDTRVANYLKIEVALAKVEAGLGVIPQDAWRDIEQKSHSFEIDWERFRID--------------------VEAVGYPVMPFVTQLAecGESGEYLHWGSTTRDITDTSFVLQLREALGVLAADLDKVRRKLREMTARHRSTLMIARTHGKHALPSTFGFRCAVWYSEVERQCERLAALRAEPFVGQFG-GAIGTLAAVGPRGLEVQSALMAE-LGLGTAE----IAWFASRDRVSEVVFRIASIAQSMASIAKSLVIMTRDELAEASE-GGGEQRGTSSAMPHKHNTVVPELVI-VHGKMATQQVAIVMESMVQDFERD-WQGHFETIAVPQTFQHAHAAVTQMHTVLSGLILHEDRMRANLdmAESVMMALAPKLghHAISRLCNQALAEDRPLGEVLRADpyLGEHELADALDPAGYIGLATQVVDNVLKA--
    222 UniRef50_Q3KCB2        Argininosuccinate lyase 1 n...   278     3e-73  1  15.9%  20:478   6:457     -------------------DRLWGARFkaALAALSRCPERYF---RLTPYDLAGSKAHAGELQRAGLLDEQETRTMIEALDGIGADFAAGRIAP---------TLDDEDVHTFIERLLTERLGAL---------GGKLRAGRSRNDQTANDLRLFLRDHVRTLAVEVLALQTALVDQAEQHVESICPGFTHLQQAQPIVFAHHLLAHAQSMLRDVQRLMDWDARTSLSPLG------AAAMAGSAIARQPQQSAKEMGYAGV-CENSIDAVASRDHVAEFLFIASMLGINISRLAEEFCLWSSRQFRWVD--LDDAYATGSSIMPQKKNPDIAELARGKAGRLIGNLTGLLSTLKSLPLSYNRDLSEDKNGVLDSVDTLLL-VLPAMAGMVATMTVNVEELRRQAPLGFTLATEVADWlaHEITGALVQACEKHDLELWEASPadPRLT-ADVRDSLTLEAAigTAPQQVREQIGRLK
    223 UniRef50_D2TK81        3-carboxy-cis,cis-muconate ...   278     4e-73  1  16.5%  42:478  17:444     -----------------------------------------FSDYQRLQGMLDFEAALARAQAACGVIPASAVAPISRACR--------AGRFDMVALAESAQAAGNLAIPMVRQLTALVR-------AEDPAAAGYVHWGATSQDAIDTGLVLQLRAALSDTQTQLRLVIDSFARQALRYQHTVMPGRTWMQQALPVTWGLKLAGTLDALLRWESRLEQLLPRSLVLQFGGAA-GTLASLKQDALP-VAERLAQELDLTLPDTP----WHTQRDRLLEVGAWYAGVGATLGKFAQDFALLMQTEVAEVSE-PVAAGRGGSSTMPHKRNPVSCAAILTAMQRTPGLMAT-LYNCQLQQHERALGGWQAEWEVLPEIMMLVGHVMQETQRLVQDMQVFAQKMRENLAITNGLLmaLATFTGKQQAHHLihQAATSQRSLLSLLLQEPQVteSQLTSLLDPAGAIGSAEHFIQRVLTRYK
    224 UniRef50_A4AHM6        Argininosuccinate lyase n=6...   276     1e-72  1  16.0%  22:477  12:458     ---------------------LWGARFapSPELARLS-KSTHFDWQLAQYDLAGSRAHAKALAAAGYLDGSELETMLDALQSLSEAVADGSFTSLE---------SEEDVHAALERGLIERAG--------AEVGGKLRAGRSRNDQIATLVRLYLLDHAGAIAAMVVDLIDAIVAQSEKHNSAIMPGRTHLQHAQPVLLAHHLLAHAWPLVRTLERLRDWKARASTSPYGSGALAGST------LGLDPALVARELGLA-RPTENSIDATASRDVVAEFAFITAQLGIDISRLSEEIILWNTREFDFV--QLDDAYSTGSSIMPQKKNPDIAELARGKAGRLIGNLTGLLATLKALPLAYNRDLQEDKEPVFDSVETL-EVLLPAFTGMIATLRFNTARMAELAPQGFSLATDvvPFREAHEigSLVRFCEEKSLELHEPSDDDYAAISpaVRAVLTVEGSvgVGGTAPIRVAEQR-
    225 UniRef50_Q9I6Q8        3-carboxy-cis,cis-muconate ...   276     1e-72  1  18.9%  16:475   3:447     ---------------DVPANQLFDAYFMAAPM------RAVFSDRGRLQGMLDFEAALARAEARTGVVPATAVAPIEAACRAELYDPLALAEAV--------ATAGNSAIPLVKALGRQVAAG-------DAEAERYVHLGATSQDAMDSGLVLQLRRALALLEQDLQRLAEVLADQAERHADTPLAGRTWLQHATPVTLGMKLAGLLGALTRHRQRLRELRPRLLVLQFG-GASGTLAALGEQALP-VAAALAEELGLALPEQP----WHTQRDRLVEFASVLGLVAGSLGKFGRDVSLLMQTEAGEVFE-PAGAGRGGSSTMPHKRNPVSSAVLIAAATRAPG-LVSTLFAAMPQEHERSLGLWHAEWETLPELCCLVAGALQQAIGLLEGLEVDAQRMRRNLGLTHGLVlaLARRIGREAAHHLvrRAVEQRRELRAVLGEEARVSAeeLDRLLDPAHYLGQARAWVERALA---
    226 UniRef50_D1B0U9        Adenylosuccinate lyase n=12...   276     1e-72  1  17.1%  42:463  14:430     -----------------------------------------WTIEAKYDAWLKVEKAATKAWNKLGLIPDSDCEKIVNNAKFDIA-----------------------RIDEIEKVTRHDVIAFLTSVADsgEESRWVHYGMTSSDCIDTAVALQMRDSLHVIIDDVKILMESLKKRAMEHKMTLMVGRSHGIHGEPITFGLVLAIWYEEIKRSLTNLENVMDVISVGQI-SGAMGNMAHSPIELEELVCEELGL----KPAPVSNQVIQ---RDRYAALMNALALLASSCEKIAVAVRHYQRTEVYECEE-FFEQGQKGSSAMPHKRNPVLSENITGLC-RMIRSYAIPAMENVALWHERDISHSSVERFILPDGFITTDFMLHRLNSVISKLVVYPENMMKNLNLTGGLvlEllKGVSREDAYKIVQraLNENKelQNLLSDeaKLSEEEIRECFDYMYYT---------------
    227 UniRef50_Q7TUR9        Fumarate lyase:Adenylosucci...   276     2e-72  1  15.0%  40:458  12:414     ---------------------------------------EIWTDRAKYQSWLDVEIAACEANCQLGKIPAAEMQQIRERA-----------------------TFEPQRILEIEAEVRHDVIAFLTNVNEHvdAGRYIHVGMTSSDVLDTGLALQLKNSVALLKQELGSLQEAIRSLAVEHKGTVMIGRSHAIHGEPITFGFKLAGWLAETMRNAERLERLERDVAVGQI-SGAMGTYANTD----PKVEQLTCERLCLIPDTASTQVI---SRDRHADYVQTLALVGASLDRFATEIRNLQRTDVLEVEE-SFAKGQKGSSAMPHKRNPIRAERISGLA-RVLRSYVVAALENVALWHERDISHSSTERMMLPDCSVTLHFMLREMTQVVQGLGIYPANMRRNMNIYGGVvlALVegMSREDAYSVVQRNatEGGNFRANLEADPEVsaKALAECFS--------------------
    228 UniRef50_B3E0C7        Adenylosuccinate lyase n=1 ...   275     2e-72  1  14.6%  41:472  13:427     ----------------------------------------VWSEEKRIEHWIKIERLVLEALASCGVVPKEEIQGI-----------------------PETVSVSIEEIKKREENLQHEILAFLEPLAdlGAAGRYLHFGLTSSDILDTTFALQLKEASELLLADIEKLIQRVEQKAVQYAFCPMMGRTHGVFAEPTTYGLKLLQMREEFKRAYGRLLAAQEEI-IHGMISGAVGTYAHLD----PRVEKIVLDKLGLKAEAVSSQVIP---RDRHAFFLNCIALVGCSIERWATEFRHLQRSEVLEVEE-PFKAGQKGSSAMPHKKNPILCERLCGLARLLRGYALS-AMENVALWHERDISHSSVERVAFPDATLLLDYMLFLLTGIVENQKVYPNRMMDnlYASEGIMLALVKkmSRKEAYEAVQQawEKGKPLSVYAQSHplLSPKEIEALCSLESYLSNVAFIFER------
    229 UniRef50_A6V1T0        Probable lyase n=6 Tax=Pseu...   275     2e-72  1  15.6%  35:476  50:478     ----------------------------------PVSRRIFCSHCRL-QRWLDVEAALALAQADVGIIPREAALEIARAARLSAVDLRQIAEGVATTGHS------------------LMPLLGALQKNCGASAREYVHFGATTQDIQDTAQSLEMRDVLDETERALDRLLERLATLASGKRDALMVARTHSIPALPTTFGLKVAGWIDELLRHRERLGEARKRILVVQLFGG-VGTMAAFGAEAMALL-ERFASRLALDVPLA----GWHVSRDRVTEFVSTLAMVTASLARIADEIRTLNRWEIGEL-EVGWTQQQIGSSTMPHKRNPEGCEQVVVLA-RLAKAQVMLALDAMILEHERDYRGTRLEWCAVADVSHYALMAMSLLDDTIGGLTVHDEAMARTADatEAFVFEMAKQLgyEIIFEITQACQRKRIPMRQALESDPRVskETLARLFEPRTHLGMAGTIVDNVLDR--
    230 UniRef50_Q1L4A4        Iminodisuccinate carbon-nit...   275     3e-72  1  16.4%  35:478  20:465     ----------------------------------HIYGPRLARDFTrfAYLTEVNQAHLLMLHKTGLVSPEVARKLANGLQQMEAEGPASVTLD----------PAKEDPYFNYEARLMTVTGR--------DIGGRLHMARSRNDIAATIDRMRARSIVLDTIEALGRVRKVALQRASEFADAVMPGYTHLQPAQPITFGFYLSAVAETLGRDMDRLHAALPRIDAMPLGAGALAGT------RFPIDRQVTADGLGF-GSLVHNTLDAVASRDFAWEAMSAMAIIALTWGRVAQDFYVWSTPEFGLLSFP--DRVASTSSIMPQKKNPAVLEYLRGKSAHIVGLLTTSLMTVKGTHFTHTGDSSRESIRSFWECCEETARCLSLFELVVGSVEPKRLNMLRRVTLDFSVATDLADGlaHHVVGGLVRMALDAGQslTSAMLDRAAVdeDKLRQYLDPVESvgPAPSEVHLAIQRQR
    231 UniRef50_Q2ITS2        Adenylosuccinate lyase n=16...   273     1e-71  1  13.8%  39:473  34:454     --------------------------------------AAIWEPLTRFKIWFEIEAHASDAQAALGVIPKEAAETIWAKGKDAAFDVA--------------------RIDEIEREVKHDVIAFLTHLAEFVGpsRFVHQGMTSSDVLDTCFNVQLVRASDILLADLDKVLAALKTRAFEHKMTPSIGRSHGIHAEPVTFGLKMAYAYAEFSRARDRLVAARKEVATCAI-SGSVGTFAHID----PRVEEHVAKAMGLAVEPVSTQVIP---RDRHAMYFATLGVIASSVERLATELRHLQRTEVLE-AEEYFSEGQKGSSSMPHKRNPVLTENLTGLARMV-RAYAMPAMENVVLWHERDISHSSAERMIAPDSTVTLDFALNRLAGVIEKLVVYPDNMAKNLDrsQRLLTALTQKgsREESYKLVQrvWRGEGDFLTLLKKDpyMSDAEIEEQFDLGYHLKHVDTIFRRV-----
    232 UniRef50_C1B6A8        Putative aspartate ammonia-...   273     2e-71  1  38.3%  22:423  27:421     ---------------------LYGEQTTLSLNNFPGPGRTFGDVPAFVRNYARVKLAAAQANHALGVLDSIRRDAIVTACREI-ASGDHPTQFPSALLLGGGGTTTNMNVNEVIAARATLLAG------VTVHPNDHVNASQSTNDSYPTAMALTVLELAEPPLEALDELVTALENKATEFDDTRHLGRTCLRDAVSLSAGQSHRAQAAAIRRTADGLRVAVGAMRSVPLGATAVGTGLGAPDGYRELAITELAAASGLDLRPAPDLFDALAHLDPYADIAAAGARTGMTMAKVAADIRLLSSGPTGGFGDLTIPAVQAGSSIMPAKVNPAIPEYVMQLSYRIRGAAHTIEFAVSAGELELNVMEPVIVDALVTIFDDLTAAAISFARRCVNGITWHGPRREENLAGAFDSWVTLSATAGYEA-------------------------------------------------------
    233 UniRef50_A8TRW1        Fumarate lyase n=1 Tax=alph...   272     2e-71  1  14.8%  41:478  22:442     ----------------------------------------LFDDDATVRAMAQVEASLARAEAKLGIVPQAAAERITEA----------TEGFVPDLEALGEGSEQ--------AGVAVIAFVQQFRVHVGGDAAQWVHFGATSQDIVDTALILQLRDALELISKRLDRVIAALATLADTHRNTVMAARTRYQQALPTSFGLKCAGWLMPLVRCRQRLTELRPRLLMVQFGGAA-GTLAALGDKGIAVM-EGMAADLDLACPPTP----WHTQRDGITEFGSWLSLVTGALGKLGQDAVLMAQTEVGELDESAGGGRGGS-STMPQKTNPVTGEALVA-AARLNATLLGNLHQGQIQEHERGGVGWQMEWATLPTMVVTSGAALAKTEALLGRLAVGIERMRANleNGLILAeaLAEYMPRPDAQALVKQAArdGGHLVDALRSRTTAT-VDWGRLRDPACYLGCNDALIDRALVAVR
    234 UniRef50_C0QEF7        Fumarate lyase (DEAD box) n...   271     5e-71  1  27.8%  22:464   3:438     ---------------------LYGEETKKALILFGPGQTA----REMIRAYGEVKLAAIRAQQEsgLYPGDYFPLLEETAKEII-EGQLDAQFPLPLSQGGAGTSFHMNLCEVLS----EGTNRKYKGDFKAHPLDHLARFQSTNDTFPTAVTLMTFRYLEQVEQKVVCLQEQLVSRETLYEEWLMCGRTELQDALPMTLGQLYSAWAGPVERDRWRLNKLKERLRTIPLGGTAIGTGYSAPRNYVFSAEKHLRRITGLPLCRSQNLCDQVAHTDNLAECAAGLGLCADNLYKMCSDMLLYSSSLSGEIR---HKEMQYGSTIMPDKSNPVLLELIRGLSMECASSAALIREYSRSGQMQLNANLPFLAEQMIRLFHSLTRALDCAAGPLMDALEPDREKMEARLAVSPALLNTLKDVLGYSRLKEliKAASPSNRdlILWLNQNTGLSKAFLHDKFNYFNLTG--------------
    235 UniRef50_A7EF71        Putative uncharacterized pr...   270     9e-71  1  12.0%  19:469  15:417     ------------------ENMLWGGRFTGGLDPLMVsnESIYYDRAFHTQDILGSIAWARANHKNGILTEAEFAAIESGLKQVEEEWVAGTFKIVP--------GVDEDIHTANERRLGEIIGK--------EIGGKLHTGRSRNEQVATDMRLWLRDELKKIESFLVDYLKVVAARSENEIEHIMPGYTHLQRAQPIRWSHWMLSYGLAFATDLQRLREVIKRVNRSPLGCGALAG------NPFNIDREAMAKELGFEGLLW-NSMSAVGDRDFVVETMQWGATLMSHLSRWAEDLIIYGTGEFSFVR--LADAYSTG-----------------------------------GLPSTYNKDLQESVEPMLDHIKTVGDSI-QIATGVLSTLTINPEKMKASLdlATDLADYlvPFRehHISGQVVAYSEKTKIPMDQLTYDQLkrFKEDVSECFDYEKSVEARQAA---------
    236 UniRef50_Q2RWH5        Adenylosuccinate lyase n=13...   269     1e-70  1  14.5%  39:473  11:433     --------------------------------------AAIWAPENRFRIWFQIEAHACDALAAIGVIPAEAAKTVWEKGDLPYTPERVA------------------RIDAIEAEVKHDVIAFLTELSEHvePARFIHQGMTSSDVLDTCLAVQLTQAADLLLEDIDALLAALRTRAFEHKMTVCMGRSHGIHAEPVTMGLKFAGFHAEFQRARTRLVAARGEIATCAI-SGAVGTFANID----PRVEEHVAAKLGLLPEPLSTQVIP---RDRHAQFFAVLGVIASSVERAALEIRHLQRTEVREVEE-FFSKGQKGSSAMPHKRNPVLTENLTGLARMV-RAYALPAMENVALWHERDISHSSVERMIGPDATVTLDFALARLTGVFTNLVIYPEAIDRTLNQMGGLvlALTqgVSREEAYRIVQRNAMeqGGLLDRLKADakLTPEALEELFDLGYHTKHVDTIFRRV-----
    237 UniRef50_D1CE80        Argininosuccinate lyase n=1...   269     1e-70  1  15.6%  20:467   2:414     -------------------SKLwgYKLDETIERFEIGHD-LAFDNELVEVDVYGSIAHAEMLNRIGILTDDELQTLKQGLGRILDLYRQGQFFM---------TPADEDIHTKIENFLV---------REYGDVGKKIHTARSRNDQVLVDLRLYAKAKILELESALLQCAESLVEFASKHEHVPMPGYTHMQRAMLSSVGTWAGAFAEALLDDLKLLETAYELNDQSPLGSAASYG------VPLPIDRQYVADKLGFAKVQNNVLYAQNARGKFEALVVQAISQIMLDLSKLAQDILLFTTAEYGFF--TISDSFVTGSSIMPQKKNLSMMELIRAKANMALGYQQQMMSVLSGLPSGYNKDYQETKKPFMEAIQLALDS-LKVAELTISNLSPNKDKLLAAC--TPElaT--------DKAYELVQ----QGMPFRDAYrnLDKLEGADPEESLKKRTHIGASG-----------
    238 UniRef50_B1HXH3        Argininosuccinate lyase 2 n...   269     1e-70  1  17.3%  46:478  37:471     ---------------------------------------------NFLTIMLQINIAHLKMLEEQGLVKKEEAKQIGAALKKI----------DLNYYRLEDYSPQYEDLFFRIENKLIELAG---------DVAGNLHIGRSRNDMGIAIYRMTLRQKLLLLMRELLTLRDDLIAAAEEHVDTIMIGYTHTQQAQPTTFAHYLKAVIDQLERDFERMQHVYKTVNRSSMGAAALTTT------GFNINRERMRDLLAFDDI-IENAWDAVAGADYIAEAASIVQLAALNLGRTSQDFLLWATQEFN--AFTLASPYVQISSIMPQKRNPVSIEHTRSLLSAVVGDASTVLQMVHNTPFGDIVDTEDDMQPYLWRAIDRLVGIYKLFGSLVVTMDVNKKKLRNRAENSFANVTELADTLVrrQAHSIVSKCIksEESLASltGKELNISEEDFYKTLQPESFvgPAPATMKAALEQAK
    239 UniRef50_A8M7B1        Fumarate lyase n=1 Tax=Sali...   269     1e-70  1  14.6%  35:478  33:464     ----------------------------------TSGSRRIYCDVCRKQRWLDIEAALAQAQGELGMIPARAVAGIVSAARLECIDLDAVQAEIDRSGHSLVG------------------LLRVLQVACPDDTGEYIHFGATTQDIQDTGQALEMRDTLDELTREIAAILASLVELAEQHAGTVAVGRTHARAALPMSFGLKVASWIDELLRHTERLATARSRVVVAQLFG--GAGTMAGFGGGGVVLLERFAARLGL----AVPTLGWHVARDRVVEFVTTLAMVSGTLGRVADEIRTIGRPEFGEVTE-PWRYGKVGSSTMPHKRNPERCEQVVVMA-KLAAAQAGIAFTAMVGDHERDARALRVEWACVPDVSHYTLAACEIVRELVTGLTVHEDRLRVNAqaTERLMLALGRQLghERVYELSQTAHDTGRPLrdCADLRDLVDERELDVIFDPSQYLGASTDLTHRALAEAR
    240 UniRef50_C0VS79        3-carboxy-cis,cis-muconate ...   269     2e-70  1  16.4%  39:470  21:438     --------------------------------------EKIWLEPAVVQNIVTVEVTLAKVQGELGMLPADASQKISQ----------FSTIRPELVEKVEAGKIGNPLIAALDA----------LRSEIPDAYRGWVHYGATSQDILDTARALQIKQSLDWLEEQLTELENLISSLTKEHSSTLMVARTNGQHALPTTLGMRFARWLAELRRCQSRLSDVRSRALLIQF-SGAAGTYASMGNQGLEI-AERMAKELGLVFEAVP----WHASRDSITELCCALAIYGQSLAKIAEDLFDMQRTDLMEARE-SMDAHASGSSTMPQKLNPFSTMKISVGARLAAGMAATVLTQPPGS-FERDHRQLEVERDALPQIFVAVEGAAQKLNKLLPRLSFSKENLSQalLLTESLMMHLAPILGQEKAHQLLQDFSaqGTSFEEFLSSHPEVKKkdWDWLTDPKSYLGLSESIA--------
    241 UniRef50_B4RI44        Fumarate hydratase, class I...   268     3e-70  1  29.4%  44:465  44:454     -------------------------------------------PPALIRALGEVRAAAALANRDCGALDQARSEALARAALQVSVQPPDAWSRPLWQDGGGAGLAYPLD-----AAILEVARGHADIRPEDVRRHQCV-------DAVQTALHMAALRLWEtlSPALAHLTGLLEQKAAAWSDLIKIGRTHLQDAAPLTLGQEVSGWLQQVRNGRSRLSAAAEDLLAVPFGQGCVGTGAGVPAGFAASAIRRLAERTGLALRPSPDALADLTGPGRIAFFHAALATLATALFKISSDVRLLASGPAAGFNELRLPETGLPCSSLPGKTNPDAAEALAQVCVQVIGADGAVSLAASQGQFESNGFLPLLAFNVLRSATLLADAIRVFADHGVAGLKPRTDVLAFNVAQSVMLVTALAPHIGYDVAAKIARDAYQRKVSLREAALASGVVDAETYERLVRPERMLGP-------------
    242 UniRef50_Q5WG84        Adenylosuccinate lyase n=4 ...   268     3e-70  1  16.1%  37:478  16:445     ------------------------------------GLKNLFTEKEKYKTWLLFESALAEAQAEYGLIPKKAAQEIKEAAKLENLDLEEMDRIYKEIGHGF------------------VPFLKVLVKACPPDSGKYVHYGITTQNIQQSSQLYILKKAHMIFMRLIGEILENLSILASDNKHTVMPGRTHGRHAIPITYGYKVSAWISELISCHQRMAEAEKRVFQV-MMGGAVGTFSSMPEIGIN-VQNRVAALVGMYPMTVPSRNINT----HKLEYMSNLALLANCCHKIAEEVYSTTLEEIAEVSE-GFSKGTVGSSTMPHKINPKLAKGIIANAQKLYS-LPSIGMYSAARPYEGDSSSYMLFEGLLEESMELMTEILIRCEELTRTLTVHKERMLHnlDNSEYVMMKLAEKLGKDQAheIAMKTAAEGQEFYDNLRENKQvtDKEIKHMIEPGNYTGLAAHLAEKEAERAK
    243 UniRef50_D0MJ53        Argininosuccinate lyase n=1...   268     5e-70  1  14.6%  19:478   3:425     ------------------WDK--GQSVAAWVQRFTVGEDYRW-DTLLLPYDIEGTRAHAAGLHRIGILSDEEFRAVSEALDALKAEVAAGRVVVR---------PEDEDAHTVIETYLTKRLG---------DTGKKIHTGRSRNDQVLTAIRLFLKDGLREAGRRVARLVEQLCELGTAYNDALMPGYTHLQQAMPSTAGLWALGYAELLLSDLAALRHAFDQVDVSPLGSAA-----GYGVPFLELPREEVARRLGFRALQLHVTAVQLSRGKLELHAAHALVQVGATLNRIASDLVLFNSQEFGFVELP--PECCTGSSIMPQKQNPDVPELVRAGYHRLLAEMNVLLTLPANLPSGYHRDLQLTKEAVVRCVLH-AHDLLTAMVQLLPGLRFRRDRMQAACTPAL-LATAEALRRVAEGvrEAYRQAAA-------ALDSLPQPDPETVLRAYRVDGYPGRGRP--DRLLEQLR
    244 UniRef50_Q9Z4S3        Argininosuccinate lyase n=8...   267     6e-70  1  15.3%  20:443   3:387     -------------------EKLwgYTVDEEVEKFTVGDDYI-VDMRIIKYDIKASIVHSKMLQRTGLLTQEEQKKIEEALNELLHLVEEGKFQI---------KPEDEDCHTAIENFLVKKLG---------ETGKKIHTARSRNDQVLTALRLMYKDELKKIKDLVVELQKSLDGFIERFGQIKFAGFTHTRKAMPTDFATWAGALRDALQDDLKLLETVYDIIDQSPLGTGAGYG------VPIEVDREFTAKELGFSRVQWNPIYTQNSRGKFEYLLLHVLSQISYDLNRFASDIIFFSLPEIGFLKLP--KELCTGSSIMPHKINPDPLELVRAYHHFVVSRMVMAVSLPSNLILGYHRDLQLLKKPVIESIDVVKN-ILRIMKIIFDRIEVDREK-------SEDSITEEV--LATHRVYELVK----KGIPFRDAYR-----------------------------------
    245 UniRef50_Q8U705        Argininosuccinate lyase 2 n...   267     8e-70  1  16.8%  45:478  33:469     --------------------------------------------NHHVDGFRRIDRAHLVMLRETGILDAETAAKIAGALEDIDRTIEPSEL---------VYTGEVEDFFFLIEKELKARIG--------VDVAGRLHTARSRNDIDHTLFKIGLKDKIDTLTAKARVLLKALIDAAERNQSTLIVAYTHGQPAQPTTFGHYLSAAIEVLIRDIERFTEARHIVDLSPMGAAAITTS------GFPIDRARVAELLGFA-APLRNSYSCIAAVDYTTATYGAIELMFLHLGRLIQDFQFWTSFEVGQIYVPN--SLVQISSIMPQKRNPVPIEHLRHLASQTFGRARTMLDVMHNTPFTDMNDSEGETQSMGYEAFASAGRVLDLLASLVGQISIDPERVDQNIRRSCITITELAdfRQAHEIAATVAkaLKGDLpfSGLTGRETGIDEEKFRQIVSPEHFvgPAPEPMREAFAAYR
    246 UniRef50_P30566        Adenylosuccinate lyase n=48...   266     1e-69  1  14.4%  14:477  12:464     -------------SYRSPLASRYASPEM----------CFVFSDRYKFRTWRQLWLWLAEAEQTLGliTDEQIQEMKSNLENIDFKMAA----------------------EEEKRLRHDVMAHVHTfhCCPKAAGIIHLGATSCYVGDNTDLIILRNALDLLLPKLARVISRLADFAKERASLPTLGFTHFQPAQLTTVGKRCCLWIQDLCMDLQNLKRVRDDLRFRGVKGTT-GTQASfdDHKVEQLDKMVTEKAGFKRAFIITG--QTYTRKVDIEVLSVLASLGASVHKICTDIRLLANLKEM---EEPFEKQQIGSSAMPYKRNPMRSERCCSLARHLMTLVMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTILNTLQNISEGLVVYPKVIERrfMATENIIMAMVKAGghEKIRVLSQQAaqEGgdLIERIQVDAYFSpsQLDHLLDPSSFTGRASQQVQRFLEEE-
    247 UniRef50_B6CWI9        ToyF n=1 Tax=Streptomyces r...   266     2e-69  1  13.3%  15:471   1:429     --------------MTTPIdgRYGSPRMRA----------LFTDRARYEAFVRVEGALATAQGRYGVIPR--------------------EAAEAIAEQARTHRCSLERVAALEETSRHELFAAVQEFAESCGAHgwVHYGATSSDILDTALALQLTEAIALLEEDLRDLLTALLARIDAVGDHVMIGRTHGQQAQPVTLGFKLAIVLDRFVRCLERLAQAKERV-VMGKIAGAVGSLAGIGAHGPEVQRETLRE-LGLPEPAVCAQAVA---RDRIAEFFCWAGLTAACLEDLATEVRNLQRTEIGEVAEPFAEGGQIGSSAMPHKRNPVQSERICSLA-RLVRSLVGPALENVTSWHERDLANSANERFTLPEACVLLDEMLTTATYVIDGLRVFPDRMRHNLEHSHnlLLLVQRGMDRLAAYRLLQeaTGEDGDMVDALLAHPRLAGR-----LDAEEVRRLAAAGAD-------
    248 UniRef50_B1NME2        Putative ArgH n=1 Tax=uncul...   265     3e-69  1  15.5%  22:465   4:432     ---------------------LWSGRFDSAPDAAaeFGASFRFDRRLFEDDVTGSLAWARALAQAGVLAADEARQIEDALTAILESGRSDPAFVDGP---------DEDVHSFVERVLVERLG---------DAGRRLHTGRSRNEQVSLDLRLYLRRRIPLLQQAAAGVIEALAAQAASAGDALMPSFTHFRPAQPVLVAHFFLSHAAPLRRDFARLQAARDECDALPLGSGAIAGTA------YAVDVDALARDLGFSRI-VDNSMDASSDRDFAATFLYACAMTMVHLSRLAEDLIIFCGDEHRFFE--LSDALSTGSSMMPQKKNPDPLELVRGKTGRAIGHLVGMLTTIKGLPTGYNKDLQEDKEAVFGAEDTLA-GSLAVGRSVVAGLTLNRDRAASAAslATDVADYlvPFRRAHevGALVRKLIAERREFESLSADEWRAASddVAARVTPAVSVGA-------------
    249 UniRef50_Q7MJB9        Adenylosuccinate lyase n=6 ...   264     4e-69  1  15.1%  41:478  33:455     ----------------------------------------VWSDENLIRTWLTFETKIAEAQAELGLIPHSAASAIKQVCDIRHLDWARLAQDTQTVG------------------MAIKPLVDQLSEQGNDEVKQYLHWGCTTQDLLDTSLAMRLKQTLHIVRQQLVALGDQLASMALHHKRTVMVARTNAMDALPTTWGLQVSGYLQEITRHLTRLDELYPRVTT-GLYGGAVGNLSSIGSHGLAVRQRLFAKL-----ELTEPKGLGNASLDNIVELIQFFALIHGTLCRIANDTELMGRAALGEVCE---GESGGGSSTMPHKANPRAANMIQTLSR--MGwyASGAPNLMDQQDVRAASMRVLNWSLVPEASLAVSTALERGERLVANLIVNQDKMRSNFsmSEAVMMKAAEKVGRSMGYSCVKMAIaeQGDLAQILKQNpiLTDQEIDAACDPQHYLGCNDALIDETVELYR
    250 UniRef50_P21265        Adenylosuccinate lyase n=16...   264     7e-69  1  14.5%   8:477   7:465     -------EEDPLARYRSPLVSRYAS----AEMGFN------FSERKKFGTWRRLWLYLAQAEKSLGliTDEQIKEMEANLDNI---------------------DFKMAAEEEKKLRHDVMAHVHTFAHCCPKAAAIIHLGATSCYVGDNTDLIVLRDGFNLLLPKLARVISRLADFAETHADLPTLGFTHYQPAQLTTVGKRCCLWIQDLCMDLQNLERARDDLRFRGVKGTT-GTQASfdHSKVEELDRLVTAKAGFKRSYMVTG--QTYSRKVDIEVLSVLASLGASVHKICTDIRLLAN--LKEIEE-PFEKDQIGSSAMPYKRNPMRSERCCSLARHLMTLVLDPLQTASVQWFERTLDDSANRRVCLAEAFLTADIILSTLQNISEGLVVYPkrIRQElmATENIIMAMVKAGghEKIRVLSQQAAaeGgdFIARVRADPYFSpeHLDSLLDPSSFTGRAPQQVAKFLKEE-
    251 UniRef50_Q1YSL1        Adenylosuccinate lyase (Pur...   263     8e-69  1  15.3%  39:475  36:460     --------------------------------------AEIFSRQYQVQRLLDIEAALARVQADLNIIPDWAAEELTRKAQ--------VSNVPLDQL------------KEERARVRHSMVSLLNIWQHSIEGgeYMHYGATTVDIFNTAMVLQLYDASAVLLDQLRLLENIMIGLADEYKATPMIGRTLGQHALPITFGKKVSSWLGENRRNIERLKAVRTQIAQSTIMKGAVGSYLGLGDKGMEI-ERGVARELGLKAPIVS---DWHPARDVFADYALTLALISKSYGRIGNELFLLNMTDIGETEEI-LPETAVGSSTMPHKKNPKVPDKLIHYSRFIPRLAEVILDDVVNS-FER--DDSSGARVVVEEITKQAASMLEDAFYALSNLTVKTSQMKANLEKTRGLImaLADKIGKTTahELALLALNTNITLREAIELSPDisKKKLDELLDAKTYLGLAVEQVEAVIA---
    252 UniRef50_Q2SR97        Adenylosuccinate lyase n=5 ...   263     1e-68  1  14.8%  41:458  13:414     ----------------------------------------IWSDENKYNTWLKVEQLVCQAWAKLGYINKQDILKINNNLK---------------VDLNRMLEIEQETKHDVVAFTR-------MLSEQLDSESKWIHLGITSTDIVDTAQNYLIKQSNQIVDNELKNICDTLKELAFEHKNTLIMGRTHGMYGEPTSLGLKFALWFDEFQRHIKRFKLAKSDIQVVKI-SGSMGNYANLE----PIIEEYVANKLDMNVDSLSTQVCQ---RDRHIFLVEVLANIASTLEKISTEIRLLQRSDVNELAEGFL-KNQKGSSSMPHKKNPISSENVAGLS-RYIKSIVNIVLENNNLWHERDISHSSNERIYLPDIFNLIVYILKRMNETLTNLVINQSQMLNHIKQafILLNYKNVTReyDLIQQITFKCFKDQSDFKDEVLKSsyVSIQQLEELFD--------------------
    253 UniRef50_Q8NNY1        Adenylosuccinate lyase n=2 ...   263     1e-68  1  15.6%  52:469   1:405     ---------------------------------------------------MAAERALSTAQARHGVITEDDAAQINQAAVLSNIDREKLWEDAKNVGYPILG------------------LVRQIASHLPEGPNGRVHYGATTQVIMDTGLVLQMTASLNALDKQIVRLGNALAARAEEHKDTVMPGRTHAQQAIPTTFGATLATFLDQIRRQRERLEEALERVRVISLFGA--GGNNAAQGEQAATVRAEMARLLDLK----DPVVSWHVERDVLGDFGWVCSTLCGSMAKFGRNIVDLSRTEIGEVFEPYN-SHRGASSMMPQKVNPISSELMIGIS-VVAGALTSTLPRLQESGHERAAGEWQGEWLVIPTLANLAGAALDEAIVVAEGMRVDTDRMSSNLAFAGGLIMalAPALGREKAHDLVYEASTKTREEHTTLAEELPIIAVqvEDLlqPADYVGEAQSM---------
    254 UniRef50_Q480B6        Adenylosuccinate lyase n=32...   263     1e-68  1  13.8%  18:474  11:456     -----------------PVDGRYGSKVK--------SLRSIFSEFGLIKYRVTVEVRWLQKLAATSAIAEVPaeQANDVLNNIVANFSEEDALTIKKIEA----TTNHDVKAVEYFLKDKIA----DNAELNAVTEFIHFACTSEDINNLSHALMLTDCRevLLPEMDNILAAMKALAIEYKTIPMMCRTHGQPASPSTLGKEMANVYVRLQRQREQIANVE----MLGKINGAVGNYNAHLSAYPEVDWHEYANelGLSFNAFTTQIEPH---DYIAELFDAIARFNTILIDFDRDIWGYIA--MGHFKQKTI-AGEIGSSTMPHKVNPIDFENSEGNLGIANALFTHLSQKLPISRWQRDLTDSTVLRNLGVGFAHTMIAYGATLKG-ISKLEVNEANLAAELDSNWelAEPVQTVMryEKLKELTRGKRVNGDSMRAFilELPEHAKAQLCE-MTPASYIGRAVAFIDELK----
    255 UniRef50_Q5LI10        Argininosuccinate lyase n=3...   263     1e-68  1  17.0%  19:423   2:387     ------------------AQKLwsVEVNKDIERFTVGRDRE-MDLYLAKHDVLGSMAHITMLESIGLLTKEELAQLLTELKDIYASAERGEFVIEE---------GVEDVHSQVELMLTRRLG---------DVGKKIHSGRSRNDQVLLDLKLFTRTQIREVAEAVEQLFHVLIRQSERYKNVLMPGYTHLQIAMPSSFGLWFGAYAESLVDDMLFLQAAFKMCNKNPLGSAAGYGSS------FPLNRTMTTELLGFDSLNYNVVYAQMGRGKMERNVAFALATLAGTISKLAFDACIFNSQNFGFVKLP--DECTTGSSIMPHKKNPDVFELTRAKCNKLQSLPQQIMMIANNLPSGYFRDLQIIKEVFLPAFQELKD-CLQMTTYIMNEIKVNEHILDDdvEEVNRLAREGMPFRDAYK-------------------------------------------------------
    256 UniRef50_D1AEI5        Adenylosuccinate lyase n=7 ...   263     1e-68  1  15.6%  40:475  12:434     ---------------------------------------RVWSDAHKYELWCRVETLVVEAHAQAGTIPAEVVEPIRKA-----------------------PPPTPERVREIEAVTQHDVIAFLTAWaePREAAAYVHFGMTSSDLLDTALAVQLVEATDILLEKADRLVAVLRDHALEHRNTLRVGRTHGIHGEPDVWGHRVADFAFAMARSRDRLRRAREAVGVMAI-SGAVGTYSNID----PAVERYVAERLGLKPADVSTQVV---MRDGISEWISALAIMATVCEAIALEVRHGQRTEVRELWE-PFGKGQKGSSAMPHKKNPIMSERLAGLA-RIVRAQIVPVLEGIPLWHERDISHSSTERIALPDASIALDYMLNLTIKLMSGLVVDAERMRANLESTGGLilELVegMSrdEAYPLVQKawETGTPFRETLRKHAalDEARLDEVCRPERFVERLGPVFDRLAA---
    257 UniRef50_A6KYN9        Argininosuccinate lyase n=2...   263     1e-68  1  16.3%  19:423   2:387     ------------------AQKLwnVRVNEEIDRFTVGRDRE-MDLYLAKHDVLGSMAHITMLESIGLLTAGELEMLLAELKNIYASAEKGEFVIED---------GIEDVHSQVELMLTRKLG---------DVGKKIHSGRSRNDQVLVDLKLFTRAELKEVAEEVEQLFHVLISQSNTYKDVLMPGYTHLQIAMPSSFGLWFGAYAESLVDDMMFLQAAFKMCNRNPLGSAAGYGSS------FPLDREMTTRLLGFDSMDYNVVYAQMGRGKMERNVAFALASIAGTVSKMAFDACMFSSQNFGFVKLP--DECTTGSSIMPHKKNPDVFELTRAKCNKLQALPQQIMMIMNNLPSGYFRDLQIIKEVFLPAFREL-KECLQMAAYIMDKIKINEHILDDnvEEVNRLASEGMPFRDAYK-------------------------------------------------------
    258 UniRef50_D2RUT8        Argininosuccinate lyase n=1...   263     2e-68  1  16.6%  40:478  63:522     ---------------------------------------SLAADERIFEADLEVDRAHTVMLAEQGIVEDDVAGQILTALDAIEVDGHDS-------------LPDGEDVHEAIETAVIERIGAE---------GGKMHTARSRNDEVAACIRYRLREDVLESIETTLALRESLVAVAEAHAETIMPGYTHLQPAQPTTVAHWALAYEGAVRRDTARLLEAYGRINESPLGGAAFAGTT------FDIDRERTAELLGFDGGPaeNSMDASSSRDFLLEATQALSTHATTLSGLAEDVVIFANRGFVDLS----DDYSSTSSIMPQKKNPDTLELVRAVAGDAAGGVQGLTTTLKGLPRAYNRDLQRATTHAWDTVDAVTEAS-EVAAGAVATADWNEETLAAEAGEGFSTATGVADLLAarTAHELVAHAAenGADyrDVLGeeSLVDPDAVEEALDPAASvgPAPEAVADQLELAR
    259 UniRef50_Q67KR2        Argininosuccinate lyase n=3...   262     2e-68  1  18.2%  29:474  48:495     ----------------------------RSYAEAVLSPIYDSAKHELLEPMMAIHRAHLVMLVEQGLVDAGTARKILAGLASI----------DLGEVAASRYDGRYEDLFFYVEDLTLKAAG---------EEAGNLHIARSRNDMGVTMYRMVLRKHLLDAIEAAQLLHRVLLRFAAEEADTVMLAHTHTQQAQPTTLGHWLTAAADVLERDIARMQAAYERANRSPMGAAALSTS------GFPISRERVAELLGFDG-LVENSYDAIAGADYVSEAAAAVQLTALHTGRMVQDLLLWCTQEYGALR--VADPYVQTSSIMPQKRNPVSLEHARTLLSYTAGRAQTVLQMLHNTPFGDIVDTEDEMQPNLWAALSTLRSVFRLLANVVGTAEVNRDLLLERARASFANVTELapFRTAhvVAALVKAAEARgrDVRdvLGRPLGVPAEKLRLALDPVHFvgVAPAEVRRML----
    260 UniRef50_A0M369        Argininosuccinate lyase n=1...   262     2e-68  1  17.3%  21:396   2:351     --------------------KLwgISIDKQIEKFTVGNDRE-LDMHLAEYDIQASKAHAKMLGKVGILEKDEVETILTELEVLKKQLENGLFHIEE---------DFEDVHSKIEFELTKKLG---------DTGKKIHTARSRNDQVLVAQQLYFKENLQQISEKAKELIEVLLGLADEHKEKLLPGYTHLQVAMPSSFGLWFSAYAELLIDDLYLLEAGLKIVDQNPLGSAAGYGSS------FPIDREFTTRELGFSTQKFNVVAAQMSRGKCERTVTSNIASLANTLSRLAMDICLYMSQNFDFITFP--DELTTGSSIMPHKKNPDVFELVRGKCNKLQAIANEMILITNNLPSGYHRDFQLIKENSIYSVEN-MKEILDVFTHSIAQIKV----------------------------------------------------------------------------------
    261 UniRef50_C3MHA8        Adenylosuccinate lyase n=1 ...   261     3e-68  1  18.0%  34:473  15:439     ---------------------------------FSEVAIDIWSDEATLQAWLDVEAALALAQAKLVLIPPEPAERIAACCD--------AKGFDYERLSKEIAFAQHPFVP----------VLKQLEELCGEPAAGFIHWGATTQNIFDTAIALQLKKTHLHLIAVLERTEERLKGLAFEHRQTLQAGRTHGQHALPMTFGFKVAGWHEEIRRSRERL-AARGKTSFLAYFGGAIGTFAAMDGKGRA-VEDEAARLLGLQPARLP----LRSSFDRVTDYLAALAVLAGSIHKIAQDIVFMQRSEIGEIEEA-FHMGKVGSSTMAQKRNPSAALVLVSLCRMLEGRLPMVL-AAMVRMDEGDSSATNIADIVVGEIAVLAASIAEGADRVLSGLHVNAEKMRRNLDLSRGlmMQLSPRIGRHKAHHLLYEaaMEGTAFSQTlmKDAGLADVELD--LSPDDYLGEIGEIIEDL-----
    262 UniRef50_A6F014        Fumarate lyase n=1 Tax=Mari...   261     3e-68  1  15.6%  43:445  27:409     ------------------------------------------SDQAQIKAMLKVEGQLALAQADVGLIPQEAADAINQATQLLEPDLVALAAGVAS------------------AGVPVPALVKALKKTLSQDFARWVHFGATSQDIVDTALILNCRELIKIYRQRLLEAIRLCVQLAEAHRGTLIAGRTRTQQAIPMSFGLKVANWIAPLLRQFERLEELVPRLLKVQLG-GAVGSLAAMG-DGADAVVKNLADRLSLQNAP-----SWHAQRDSLVEFSGWLAMTTGILGKMAEDWLRMAQTEVGELRF----SNGGGSSTMPQKCNPVNAEIMVTMARQNAG-LAGQMQQCMLHEHERSGYAWTQEWLLLPQMLMGTAVSLRHCLEGLESLEISAENVETNIAKSHGLifALAAHMSREDASRYVAEACetGQHLFEVLKAL---------------------------------
    263 UniRef50_Q93JQ9        Argininosuccinate lyase n=1...   260     7e-68  1  15.0%  20:478   3:456     -------------------EKLWGGRftDITDDVLRYTETASVDSRMLEHDLWQNIAHVLMLGRAGINTEPDTKALLAGL---------LDMESSRADGGLQLDVRQEDVHLNTEFMLIERIG---------PVGGRMHTARSRNDQVQTDARMVTREWLLDASEELLMFVQDLLGCPESEREAVLPGYTHSQAAQPISVAFWKAAHAQALLRDASRLMDAWKRININPLGACALAGTT------FALDRDYTSRLLGFD-APMVNALDATSTRDWTVEVAGAAASGAVNLSRMQEEIVTWSSNEYA-LAEV-HDSFATGSSIMPQKKNPVVAELARGKSGRAVGALVQLLVMEKSVGLGYSCDLQEDKPVYWGALDTYLDTIRLCRRQNLHTA-FDGARGRALCWDNFSTATEivPFRTAHRigDLVNAALGGGHTLRNVaeHDIDISEVDMKQICDprSYISAGSTGPTRVSEQQE
    264 UniRef50_A0RGU8        Argininosuccinate lyase n=8...   260     1e-67  1  18.5%  42:478  38:474     -----------------------------------------FQRNYLLKDMFQVHKAHIVMLTEENLMKKEEAKFILHALKKVEEIPEE----------QLLYTEQHEDLFFLVE--------HLISQEAKSDFVSNMHIGRSRNDMGVTMYRMSLRRYVLRLMEHHLLLQESILQLATDHKGTIMPAYTHTQPAQPTTFGHYTLAIYDTMQRDLERMKKTYKLLNQSPMGAAALSTTS------FPIKRERVADLLGFTNV-IENSYDAVAGADYLLEVSSLLMVMMTNTSRWIHDFLLLATKEYDGI--TVARPYVQISSIMPQKRNPVSIEHARAITSSALGEAFTVFQMIHNTPFGDIVDTEDDLQPYLYKGIEKAIRVFCILNAVIRTMKVEEDTLKRRSYKHAITITDFapFraHHAASVIANMSLEQKKELHELclQEkqLLEKEWEEIISPEAFigPSKKEMERMINNRK
    265 UniRef50_A3UHH3        Probable lyase n=1 Tax=Ocea...   260     1e-67  1  15.0%  38:478  62:490     -------------------------------------IEAVFSTQALNAQVLRLEAALARAQAQEGVIPQSA--------ADAITAAAIPDNIPQDAL----------DAEYDVVRHRMVALLNVLRRSLDEDSANYLHYGATTVDLYDSAAMLQMREAVLALIADLRVIELQLIELAERYKSTPMIGRTLGQHALPLTYGKSVSGYIGENRRHIDRLADLLDRIDRSIIMKGAVGSYLGLGPEG-QRVEARMAQELGL---PAPYPDDWHASRDVFAEFALVQSMMAHTWARFGQEVFLLQMTDIGAVVEER-PGGAVGSSTMPHKVNPSLSEALIQ-HGRVIPRLAEIVQDDMINFFERDNT-SRPNRAVGD-VAIATEDMLGDASRLISRLRVNEARMAETLELSEgiVFAIQDDLGrhRLRDLAADASETGVSLREALESDPDlaPGELDALLNPRTYLGLDAALVDAVIAQAR
    266 UniRef50_A4WYP6        Argininosuccinate lyase n=5...   258     3e-67  1  16.5%  12:478  20:487     -----------YGQMHVLQDVTFSVATG---ERIVVCGPSGSGKSTMIRCINRLEE-HQSGPIRVgvIPADCARDLLRGVATIRAEGPGAIDLDPQ----------FEDSYFAFENRLGQIAGR--------GVAGWLHVGRSRNDIGATLDRMAVRETCLALLAEMEATRRACLEAAGRHVLTVMPGYTHLQPAQPITFGYYLANVAQGMEREHERLAAVLDRADACPLGSAALAGTS------FPIDRDETAALLGFA-RPAVPGLDAVASRDFVTELLWAVTSAQVLFSRVAQDLYTFTTWEFGALSFP--DRVAGTSSIMPQKKNMLPLEYFRAEAGRSIGALAGALSAVKGSNYSIGLDSVREGVADAWPAFARFRAALPLLRLILETATPDAEKLLQRCKANFSTATDLADGlaHHVVGRAVQRVLATGGGAEDLTVerFDLPEERLRRWMDPVEAvgTAPEVVTAMLARME
    267 UniRef50_A9NHU6        Adenylosuccinate lyase n=2 ...   258     3e-67  1  13.8%  39:458  11:412     --------------------------------------ETLWSDQNRYDTFLTIELAVAKAWYLLGKYDETTYNKLTKA------------------------TFDLESIYALEIETKHDMIAFTRTVSKSLGAEkwLHYGLTSTDVVDSALALILRQANQAIRSKINKLLSVLKQKAYTYKDQPTIGRTHGIHAEITSFGLKFALWYSDLKRLLSVFDAACKNIEVIKI-SGAVGNYAA----NTPQLEKTVSRLLDIASADISTQVLQ---RDRHANYISSIALLGSELEKIATEIRHLSRTEVSEVNE-YFSVDQKGSSAMPHKKNPVSSENISGLS-RVLRGYVLTAFENINLWHERDISHSSAERIILADATTLIDYMLDRITNTLSNLEVHALKLQNNIDITGGIVFslTRDHAYDLVQKIATDAMSNQKDFKTELLKskFMTPDELDKAFD--------------------
    268 UniRef50_Q1L4A5        Iminodisuccinate carbon-nit...   258     4e-67  1  17.8%  36:478  18:463     -----------------------------------IGPRLFGNLDRDFLEMSKVNRAHVVMLAEANVLAPDVAVGLLEGLARIDERGLSSLEL-------------NPDREELYFNLEHALI-----EDVGADVGGRLHTARSRNDLYATVMRIKVRGYSVQMSHLLLDLVEAVIAKASAEMKTVMTGYTHGQPGQPITAGHYLSGISEALLRDAARILEGYDRINLNPLGACALATTT------FPIDRNRTGELLGFDG-LIENSLDAVGSRDYVPELIFGFAMAATTVSRFCADLHIWYMAEFNYIG--IDDSIAGTSSIMPQKKNPSPIEHLKAKASHLYGALMTSLAAQRGAFFTHGREVGTESTSGFGEAVKQFEAVAELAGAVVNGLVFNRERLIEAVDSNFSTMTELAdfRDAHkvGAIAREASLKKLeaSSVIGNAPQLTSDELRTALDARRGvgPSERSVSKMLADQE
    269 UniRef50_C6JQT1        Lyase n=7 Tax=Bacteria RepI...   258     5e-67  1  16.1%  37:478  16:450     ------------------------------------GIKELVSKEAKYQAWLNIEAALAKAQSEFGIIPKKAAENIEKAAKIEYIDFKLMDEIYKKIGHGFVPFI----------KVFIKACDEISGENESS---KYIHYGVTTQNIQQSGQLIILKQVHEKYLLICSKILENLAELAERNKDSVMAGRTHGKHATPITYGYKVSVWISDILASVERMKEVEKRVFKI-MMGGAVGAF-NTSGETGRKVQNRVAEILGMYSMEVPSRN--ITSHKE--EYIMGLALLANNCHKIAEEVYTTSIEEYGEVSEAY-EEGTVGSSTMPQKINPKLAKGIIANSQKLYS-IVPMGLYSGSRPFEADSSSYMLFDAALEEAMELITEVLLRTEELTRTIQIFKERMYQnlDNSEYIMMKIAERLGKDKAHSIIYesETEHKDYLQLLKENEVIseEDIKNMLKPENYIGLSSELAEEMAEKAR
    270 UniRef50_B6HHB0        Pc20g14240 protein n=8 Tax=...   257     6e-67  1  15.3%  16:473   9:457     ---------------QTPLNSRYASNEMK----------YLFSPRKRFSTWRELWTWLAEAQKELGliSAEAIEQMKAH------QVIQDDEFAVAA--------------EEEKRRRHDVMAHVHAFgvAPAAAGIIHWGATSCYCTDNADLILLRDGLDILIPKLAVVVDKLSQFAQKYKDLPCLGFTHGQPAQLVTVGKRACLWIQDLLMDLRNLERARDDLRFRGVKGTT-GTQASfdHAKVESLDELVTEKAGFSSAFIISS--QTYSRKIDVDVGNALGSFGATCERIGIDIRHLAM--LKEVEE-PFEKDQIGSSAMAYKRNPMRSERLCSLGRHLQNLPKDGLDTYSAQWFERSLDDSAIRRISIPELYLTADACLILLNNVSSGFVVYPEVIKRHVnaTENIIMavAKGLSRQDAHEEIrnVKKQGkdLIERIRRTAFFNppQLDTLLDASTFVGRAPQQVEKF-----
    271 UniRef50_P44797        Adenylosuccinate lyase n=56...   257     8e-67  1  13.6%  18:473  11:455     -----------------PLDGRYQDKVTPL--------RAIFSEFGLMKFRVAVEVRWLQKLASTADIT--EVPPFSTQANAFLDGIVANFNEADAARIKEIERTTNHDVKAVEYFLKEKIQNEV----ELVKVSEFIHFACTSEDINNLSHALMLSTARDeiLPEWQKLIDEITRLAEEYKTIPLLSRTHGQPASPSTVGKEMANVVYRLKRQFKQLQNAE----ILGKINGAVGNYNAHLSAYPNIDWHKFSEelGIQWNPYTTQIEPH---DYITEFFDAVVRFNTIIIDFDRD--LWGYIALNHFKQRTI-AGEIGSSTMPHKVNPIDFENSEGNLGLANAVMTHLGQKLPISRWQRDLTDSTVLRNLGVGLGYCLIAYASTRKG-ISKLEVNQPHLLEELNQNWelAEPIQTVMryEKLKELTRGKRVTEQAMREFIDKLDIPQEEKLrqKLTPATYIGAAVELVEKL-----
    272 UniRef50_B1L6M1        Adenylosuccinate lyase n=1 ...   256     2e-66  1  15.7%  18:469   5:437     -----------------PIDSRYGSELMRA----------IFRQENRIKLMARVEALYARALAERGFIPK----------------------EAAEAIERAAEEVTPEDVRAEEALVKHETMALVRasKRAGRYGEYLHLGLTSNDVLDTVMGVQIRQAGSIILRSSASLLEKIVKRGEESLDIVCLGRTHGVVADPIPLSMKFALWSYYVRRSIARFMDSLNEASVGKL-RGAVGTAAalGIKDPLEVESEVLAALGLSPPEITTQVVP---RDRLAHLILSMSLFSSALDTIANEIRNLHRTEISEVKE-HFEERQVGSSTMPHKMNPINSEKVCGLA-RLMRSLAIAALENVVLEHERDLTNSSVERAILPEAFLILEEQINTLSAVIENLEIDRVRIGENLEksERLMIWLVKklGRQEAHEIVrrSHRSGRRFIDEVLADESLspEEIEAIFSPRSYLGLGREL---------
    273 UniRef50_C2EBC5        Possible aspartate ammonia-...   256     2e-66  1  41.4% 187:471   1:285     ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MGRTQLEDAVPTTFGKEFHAYYRVLMRDHKRIEAASASLLEVPLGGTAIGTSICATQEYCDAVVPELRRLSGMPLTQAEDLSDAVQNTDCYVALSSAYKNLATDLIKITNDLRLLGSGPQAGLHELELPKVQAGSSIMPGKVNPVIPEVCAQAAFQVVGNDAAIALASSSGQLELNAFEPVMFDDLFEDASLLRGALLTLKKNCLDHLKVNEQRCAEMAAHSAGLATALSPTIGYRAAAKIAQEAVATGESIEVLLKEKINIPDSKIKELLNPQNLLQPANSSVK-------
    274 UniRef50_D0LZ81        Adenylosuccinate lyase n=6 ...   255     3e-66  1  13.7%  39:477  11:430     --------------------------------------AALWSDAARFETWLEVELAVCEAMEQTGIVPA-------------GQAAEARARAAGKLDPARILEIEKTTRHDVIAFLTHV-------EELAGEPARWLHFGMTSSDVLDTALALTCRRALERVEAGIDGLRQALARRAREHAHTPVIGRSHGIHAEPITAGLVFARWHAELGRAQARVERARAAISVGKI-AGAVGVYGNIEPGIEAAALGA-------LGLAPETVATQVVARDRHAELLCALALLGTAIEQIAVGVRHWQRTELGE-AEEGFGAGQKGSSAMPHKKNPILSENLTGLA-RLLRAYAGAAFENVALWHERDISHSSVERVSLPDATILADFMLARCQRVIDNLVVHPERMRENLErsEAVLLALVRarAYEMVQRCALAAHAGEGDFRQLLGADSdlSENALDAAFDLDHHL----RHVDLILERA-
    275 UniRef50_Q05911        Adenylosuccinate lyase n=68...   254     4e-66  1  15.0%  17:477   9:461     ----------------TPLSSRYASKEMSAT----------FSLRNRFSTWRKLWLNLAIAEKELGlvTDEAIEQMRKHVEITDDEIAKASAQ--------------------EAIVRHDVMAHVHTFGecPAAAGIIHLGATSCFVTDNADLIFIRDAYDIIIPKLVNVINRLAKFAMEYKDLPVLGWTHFQPAQLTTLGKRATLWIQELLWDLRNFERARNDIGLRGVKGTT-GTQASfnHDKVEALDERVTELLGFDKVYPVTG--QTYSRKIDIDVLAPLSSFAATAHKMATDIRLLAN--LKEVEE-PFEKSQIGSSAMAYKRNPMRCERVCSLARHLGSLFSDAVQTASVQWFERTLDDSAIRRISLPSAFLTADILLSTLLNISSGLVVYPKVIERrfMATENIIMAMVEKNasHQAAAVVKEEGGEN-DLIERVKRDEFFKpeELDSLLEPSTFVGRAPQQVEKFVQKD-
    276 UniRef50_Q123L3        Argininosuccinate lyase n=2...   254     4e-66  1  14.6%  20:478  20:475     -------------------EARLSAPPAARLVKYH-DLPGLEREKKQFQEFVAVDMAHTTMLVEEGIISTAAGRAILQQLLAIRR--MEPADFPTDVRKGSFLLQ----------------IESYLFAAIGEDVGGQMHTGRSRIDQGATVRRLYKRNRMLDVMDQLNGLQDAIAQQARRHARTIMPGYTHLQHAQPWVFGHYLLSFSSRLHDSFERLAQAYGRVNRNPLGAVGLAGTS------WPLNRMRTTALLGFDGLVENSKLGREAY--YAAEAIGALAFVMADLNDLATDLHLWSSTEFGLVE--SDDSYCGTSSIFPQKKNPAGLETIKKAAGSAVTWLATALATFRA---EGTGDQAMRELPLIDEALATTEGMLDLFTGVIETLIVHDDRMAESLSGSwnLADVIVRERghHIVARVVRNCIAQGTAPADLTSaeLRLGDEAVRDALDPRRFVEtaPLQVARLLAHAQ
    277 UniRef50_D1W006        Adenylosuccinate lyase n=2 ...   254     6e-66  1  14.1%  18:464 107:543     -----------------PIDGRYRSKTVALADYF--------SEYALIRYRIRVEIEYFIALCE---LPLPQLQNFNHSLFPRLRDIYQKFDETSAQRVKDIEQVTNHDVKAVEYFLKEEF----DKIGGLETYKEFIHFGLTSQDINNTSVPLSIKEALHEVlpCIEELIEQLEAYAAQWKDVPMLAKTHGQPASPTRLGKELMVYVYRLREQLMLLETCKMSAKF----GGATGNYNAHHVAYPAIDWkfVQEKLGLQREQYTTQI---SNYDHMGAFFDALRRINTIVLDMDRDFWMYISMEY---FKQKIKAGEVGSSAMPHKVNPIDFENSEGNLGMSNAILQFLAQKLPVSRLQRDLTDSTVLRNVGVPIGHTMIALQSTLKG-LRKLILNEDKLYQDLDKTWavAEAIQTILRREAyyEALKALTRTNQQMTEQTIHelDVSDEIKKELmtPHNYTG--------------
    278 UniRef50_A4X707        Adenylosuccinate lyase n=3 ...   254     7e-66  1  14.9%  41:463  13:410     ----------------------------------------LWSDDARYATWSKVELLATQAQAMLGRVPEPALADIQQA-----------------------RVPSVARVAEHERQRDHEILAFLAaeNIPADSARWVHLGMTSYDLVDTALGATLARACDVLLEAVVRLRGVLVDQALAHWETVCIGRTHGMHAEPTTLGHKLAGFAFATDRSVRRLRAARSEVAVGTI-SGSVGTYALID----PFVEEHVCAELGLGVEPAPSQVVA---RDRHAQLLHALATLGACVEQLATEVRLLSRSEVREVEERRTAGYQ-GSSAMPHKRNPTASERLVGLARLLRG-YAGTTLENVALWHERDLSHSSVERVVLPDAMIVAHYQTSRAADLVAGLEVFPDRMRAMVEGNGglADLLAGGIERERAYRSVQAAAngDGDFATLLRAEG------IDValRPERFL---------------
    279 UniRef50_Q2S0F5        Argininosuccinate lyase n=2...   253     9e-66  1  17.2%  27:427  14:395     --------------------------TDDWAHRFTVGDDYEW-DRLLLPYDVRASRAHAWGLRQIDVLSETEWTRIGDALDALLDAFEAGDVTV---------TPEDEDCHTVIERFVTERAGA---------AGEKLHTGRSRNDQVLAALRLYLRDALAAIGGRAAALADALCELATRHPDVLMPGYTHLQRAMPSTAALWTLGYAETLAGDLDALRHARRRINVSPLGSAA-----GYGVPVIDLPREAVADRLGFRAVQTHATAVQLSRGKHALAVGHACTQVGATCNRLASDLVLFATAEFDFVDLP--PEHCTGSSIMPQKQNPDVLELARAYHHRLAAQMQSLATGPSNLPGGYHRDLQLTKAAVLRSVEMTSD-VLTALAEVVRGVTFNPERTRAACarALERVAEGVPFraYQQAADA---------------------------------------------------
    280 UniRef50_Q0SH25        3-carboxy-cis,cis-muconate ...   253     9e-66  1  18.3%  40:475  23:440     ---------------------------------------ALLSDRAWVTALVEVEGALARAEAKCDVIPAASADAISSVFARVVAEGSVDVGALGVAAAAGG--------NPVIP--LVKLLRSEVAAADLGVSGSHVHKGATSQDILDTALMLLCRRSGAHILASLDEAVVCAEALARAQRDTPIAGRTLGQQALPTTFGVLAAGWMTALHRASRALFDALDGLPV-QLGGAA-GTSAALYPHGLD-VADVLADELGLARQDVP----WHTDRTRIALLASALGTAAGAVSKIATDLVFLSSTEVGEVSEGSP----GGSSAMPHKRNPVAAIAARAAARRTPG-LVATILGSMDHEQQRAAGAWHAEWETLTDLLRLTGGAVARIADSLGGLNVHPDAMARNLDITGglAERVTGALSadNARALVTAACETGHPLDEDPGLLEYLQADEIRALLDPAGYLGHAHDIVDRALE---
    281 UniRef50_Q8KTQ9        Argininosuccinate lyase n=1...   252     1e-65  1  15.7%  19:457   2:419     ------------------WSGRFSSPVCAPVQSFTAS---VGFDRAMCHCDAAVLAAHCRSLYLRRVMSIADLADVERGLSEVAMGARAGAISWRPEL---------EDVHRNVEHVLTELVGK---------AGRMAHTGKSRNDQVSTTARVWLRHMAGAAICRVEELERALAARSRACLNTMMPGLTHMQVAQPVTAAHYLTAYRCMLSRDRSRLVRCTRGACVLTLGSGALAGTNHGG------DRYTTADMLGLHCVS-PNSLDAVSDRDFVMEYALCCAVLMVHMSRLAEDMIAWSSSIVGFA--VLGDALCTGSSIMPQKKNPDILELVRAKAAVLIGGAMGIMAVMKAQGLAYNRDNQEDKAVLLGASRAVTRS-LSVMALAVRSLRLNKSRLRRRLESSFAIATDLAdfRdhEAVARAVGVAIRAGHalRALPLCSRGVVPPLLAARL---------------------
    282 UniRef50_A8RJS2        Putative uncharacterized pr...   252     2e-65  1  15.8%  22:463  26:459     ---------------------RLSTQPSDSVCKYIYMPILQDDMEHSYQNLLLTHISHILMLCEQKLISQEDGK---NALDFIVPLMDMHP-------QTIGFNPLNEDYFLNFEQYLISHLG--------IDLAGKIYTGRSRNDMTPTVMRMSIRDSMLAVYERLLALIRRLLALAEENQGRIITGYTHCMPAQPITLDHYFLAIAEALVRDMDRLLSAYQNLNRSPLGACAMAGTS------FPINREYTAQLLGFDGI-ITNTLDAVATRDYLLELAADFSTLGSTLSRFAQDLYLWSTAEFNYVSF--SDAYSCCSSIMPQKKNPLSIEHIKSKSSHLTSTYLDIAMCLKGTSYGHCRDLFECMPPFWDAVEQVT-GMLELSIGTLQDITFHYDRMEFTASMNDSILTDMapFRSAHNI--IASAVRAQgiTLKQllGHDTTLTESEWASLQSPRSSV---------------
    283 UniRef50_C7MPV5        3-carboxy-cis,cis-muconate ...   252     3e-65  1  17.0%  44:478  32:454     -------------------------------------------DAAWLRAMLDFEAALAAAQADAGLIDRLHAERIERACHHNGHDDY--DIAELGRAARGAGNPAAPLVRAITERV-------------EGAAARYVHWGATSQDVVDTAAMLVAARARMALLADVEACTETLAELADEHAATVQVARTLSQHALPTTFGLVAAGWLTSLDTAAERLQAVR---LPVQFG-GAVGTLASLGESGVEVLAALAA-----RLGLAEPALPWHTDRTPVAELAGALGGLAGAVSGVARSIVTLTQTDVGELREQG-PPGSGGSSTMPHKRNPVAAVSALACAKQAPG-LVADLLAAMEHENQRASGAWHAEWWPLIQLWRVCGSAVHWLRTSLDRLRVDAERMRQNLDRGGGVltELAPVVGRLAAHDAvhRALDEGVPLADVLVDDPllSRERIERLLDPADYLGAAPVFVRRALEKYR
    284 UniRef50_B5Y8W3        Adenylosuccinate lyase n=1 ...   251     3e-65  1  16.5%  35:477   9:426     ----------------------------------DSSIENIWNEDNRYDLFYEVELAYLKAEAMLGKIPADIPDYLERNRPSFSAEEIENEEKI--------------TRHEVVAFINVV-------SRKLDKYTEYFHRGLTSSDIMDTVFSLQIKQSLRHINALTDETIKVLTEKADQFKHNACAGRTHGVHAEPYFFGLRFLTVAVALKRSLNMLAALEQSIP--GKLSGALGIYTNLDPD----IESEFLRILGLSALPVSTQIVP---RDVYAPVLFYLALEASILDKLAQDMRILQITEIGEAQEE-FKRGQAGSSAMPHKRNPVRWERISGLS-RVLRSQVNVALENVSLWFERDISHSSTERIVYPLCFDLIAFMLKETKSLVSNSVFDSSRMLANMSNSKNlaLSlqQKLGREAAYKRVQDLSreAEDFIEALRSSGLLSEEELQSITDVSDL----HAKVDLIYERA-
    285 UniRef50_Q8U483        Argininosuccinate lyase n=1...   251     3e-65  1  18.1%  37:451  17:388     ------------------------------------YISSMEEDREIVEEVIECLIAHVKGLIHSKLIPEEEGEKILKALEELRASKEAL------------FSIEAEDIHEAIEIYLKEKLGKT---------GGYLPLGRSRNDHVVCALRLKAKKALVEEIGLILELRKALIKKAEENVYTLMPLFTHLQPAQPSTFAHYLSAIIEELEDITKILFSGLGIVDKSSLGAGAIGGTSVL------LDRGYMGGIL--FSDIITNSLYATSSRTFLLYSCFLSVLISIALSRIAEDFVIFSTPNFGYIKLPN--EHLSTSSMMPQKKNPVTMEVARAWAGEAIGHLVAMMSILKALPSGYNLDMQEVNKHAF-ALFSGTIKTLKIFVDAMKRVEVNKENMKKDCDIFPILATDYAEKI-----------AMNTGRPYREVYMEVASIIGE---------------------------
    286 UniRef50_Q5ZXD1        Adenylosuccinate lyase n=29...   251     5e-65  1  12.5%  18:473  11:455     -----------------PIDGRYVNKT-RALSPY-------FSEFALTYYRLMVEIKWFESLAANDTIP--EVPALDNKARKFLSDLISNFNESEAEKIKEFEKQTNHDVKAVEYYLQDKFQENEQLKSCVA----FIHFACTSEDINNLAYALMIKQAIAQVipTIAEIMGSITLLGKQHADVAMLSRTHGQPATPTTMGKELVNFVARLKRPQQQLAEVLIPAKFN----GAVGNYNAHVAAYPEVDWRKHCasLGLSFNAYTTQIEPH---DGIAEVSQIMVRINNILLDYTQDIWSYIS--LGYFKQKTIAE-EVGSSTMPHKVNPIDFENAEGNLGLSNALFIHFANKLTQSRMQRDLSDSTVLRNLGVAFSYSLIAYHSVAKGN-DKLQINKSALQKDLSENWelAEAIQTVmaYEQLKELTRGQMIDAENLKKFIKTLS-IPEEAKAEllTPETYTGLATQLVKAF-----
    287 UniRef50_C6WMX3        3-carboxy-cis,cis-muconate ...   251     5e-65  1  16.3%  37:478  16:458     ------------------------------------GVDGLLDDRAWLRAMITTEVALARAQARLGVVPEAAAET--------IAAAADPDAFDWPGLVEGVHATGNPVVAFVSQLTAIVRAADTAAPATGPSAADHVHRGSTSQDVLDTATMLLCRDALRRLRTDLLATAAALAALAGRHRDTPMAGRTLTQHAVPITFGLKAAGWLAQVLDAVERVEAVLDGGLPVSLGGAA-GTLAAYGedGDPLdvEPFAAELGLAPQ----ALPWHSARTPIADVASVLAFASGALGRLAADVAVLSRTEIGEVAEPAEP-GRGASSAMPQKRNPVHATAILTAARQVPA-LVSVLHQCLVVEDERSAGGWHAEWQPLREALRLVLGAARNAAALTAGLRAFPDRMRENLALTGGAvaRLTPVLGKVETKRLLTEATasGRplPDWllAGAGPDLEALRALCDPRGYTGASGALVDRAVERWR
    288 UniRef50_D2RX70        Adenylosuccinate lyase n=1 ...   251     5e-65  1  15.3%  18:474  12:461     -----------------PLDGRYSSRTAPL--------SPYASEAALMRARVRVEVEYLVALADLEATPLELDLEEREHLRGLYKHFAEEDARLIKKLEtgEFEATNHDVKAVEYFVRHELPA-------DSDASAWIHFGLTSEDVNNLAHRLLVRDAVDelLPELYEVRDALAEMAREHQDLPMLARTHGQPATPTTFGKEMAVYASRLARATGRIRRATDDLR--GKLGGASGTYAAHHAAYPEVDWPAFAEelGLEFEPLTTQVNPC---DDLATLFDAFRGANDVLLDLDLDIWLYVSDRYLG---QEAVEGETGSSTMPHKVNPIDFENSEGNLSKANSDLTFLADYVTTSRLQRDLSDSTVKRNIGAAFAHCLIGYTKAAAG-LEKVVPTERVMREDLESTPEIIGEAVQTiaYERVKAVTRGKDVTIEDFREMFDDLEV--DEDVReaLTPTDYVGVASDLVDDLE----
    289 UniRef50_A8S1Z4        Putative uncharacterized pr...   250     1e-64  1  18.0%  23:478  30:482     ----------------------YPGKALVAMELEPGYERAKNRMLPYIQA---INEAHLIMLMEQGIVDENSGNVILKALGELDQEFYKNT----------VYDGRYEDLYFYMESKLIEA---------TDGIAGNLHLARSRNDMCVTWSHMAVRDGLLQAMEQFLYLKNAIVLFAEEHKDTLYVIHTHTQHAQPGLLGHYFLGAADMLERDFKRLCRAYDAVNQSPMGAAAVTTT------GFPVSRERVAELAGFSGM-IENAYDAIGNSDYLTQTASALGLCALDMGRIVTDLLLWATQEMNMIH--VADGYISISSIMPQKRNPIALEHLRSSLSVLKGMADTVLTGFLKSPYGDISDYEDIEDSVFGCLELFQKNV-QLFRAVISTLEVNKELLESRAYESFSVVTDIapFRKAHsvSFLVKKAGTMDYNLKNISEehEFFGEPfiSQCINPWHFvgTGDKAMKSMIDRAK
    290 UniRef50_Q23FJ3        Adenylosuccinate lyase fami...   249     2e-64  1  12.6%  18:470  35:481     -----------------PLDGRY--------EKNIVSLKEYFSEKALIKYRINVEVEWLSFLIEKNMVKNERGESIKISPLDLVHLDAIQQKFDIekRVKEIESITNHDVKAVEYYIK----EQLEKIPVFNQVKEYVHFCCTSEDINNLAYSLMLNDanKILLKTLEEVQTNLISMAENNSAVPMLSRTHGQVASPTTVGKELANFAYRANRQINQIKNAKFSAKLN----GAVGNFNAHIFAYPEFDWSSLSQelGLEFNPYSTQIEPH---DSIAEFYNTLSLLNTIYIGFSRDMWNYIS---IGYFKQRSKKSEVGSSTMPHKVNPIDYENCEGNLGMANSVMKHFSEKLPISRFQRDLSDSTVMRNHGIAFGYSVVGYKSLLKG-LDKVEVNNQKLQEDLNQHWelAEPIQTVMryELLKDMTrkSVVTKEDLHSLIHKLKVPADVklD--LTPGTYIGNAEQMA--------
    291 UniRef50_Q9UX32        Argininosuccinate lyase n=9...   248     4e-64  1  19.1%  23:430   6:376     ----------------------WGSEKDEVVN----YTSSVDSDREIIEEVKLTMKAHVISLYLTGYLGKETARKILVALNEFKEIG-----------------QGYEDIHEALEDFLIKKVG---------EDAGWIGLGRSRNDHVATALRLRLRNKLIELLTDINSLRKILLDKAKEHITTIFPSYTHLQLAQPTTFAHYLTYIEEELASRWEIIFSTLKQVNKSPLGSGAIVGTN------VKIDREKEAELLGFDSIIYNT-LSATSSRADILSTISELTVLMVVLSRIAEDLIFFSSNKLIKLP----DSHVSTSSLMPQKRNPVTMEILRAKAAESIGMLTSLLSIYKGLPTGYNLDLQEMNKYYWLVINY-TKSSIGVLSSLFSQIQVNKINIDES-SLATDDAELlvPYRsyFEIAKKVRE------------------------------------------------
    292 UniRef50_C9SS79        Argininosuccinate lyase n=1...   248     4e-64  1  14.1%  10:464   4:445     ---------DNMKAHASLTESRLGTKASRLLIT-HVNKLELDDELISIKEYVLTDLAHAVMLTRAGIFDAQHGASIVQALVKLH---------DSDTYAVLAPDPEVGTLGLQIEKYLEKVLG---------PRGRDIQRGRSRIDQKATNWRLINRASLTDVIRELVDLATEILATADRHTGVLMPGYTHMQHSQPTTMDHYLNAHYWAVSRSLDRLYDAYDRLNVCPLGGAAYSGTS------WPINRDSTSTYLGFDRPILNARDAGFAAIDMGAELAGVLAGTLSTISRLASDLNYWSSSEVNLVR--IDAALCGTSSMMPQKRNPMVLERIRGLAGVAVGWAASHLGVMHTATST-DVD-QSYVHNLLPGQCIETVGAIALLREVLATAEFDVPAMRISAGQHWSTASALAdfRDAHevARLVEAHERAGceLRGKLIDDAflSESDVRSILDPVSFVE--------------
    293 UniRef50_Q4J8F0        Argininosuccinate lyase n=3...   247     5e-64  1  18.0%  21:436   4:380     --------------------RRWGSD-----KDFVISYTSSnsDKEIVEEVKLTLKAHVIELYLSNYISKDTAKKIIRAINSFKDYP----------------SSGYEDVHEALEDYIIKNIG---------EEGGWVGLGRSRNDHVATALRLRTREYIFDIMEELYLLRKSLIEQAKKNLNTIMPSYTHFQPAQPTTLAHYFMYLEEELNTPWEALFNSLKLINRSPLGSGAIVGSN------VKIDRKREAELLGFDDVLYNT-ISSTSSRIDFINAISSLTLLMLVLSRFAEDMILLSSMFVNIIKLP--DSHVSTSSLMPQKRNSVTMEILRTKVGECYGDLSSLMMIYKGLPSGYNLDLQEMNKHYWNCIKHVIPSI-HITRDIIQNIQI------KNFGEIQGlaTDLAEEMayRKAYIDVANKIKAGT------------------------------------------
    294 UniRef50_Q1J3Z8        3-carboxy-cis,cis-muconate ...   246     1e-63  1  16.4%  39:478  21:443     --------------------------------------AALFTDEVYVRRLLTVEGALASVQGRLGIIPPESAEAILH----------LTQTFSPDLASLRAGLLTD--------GVPVSALLAQLRPALPAAARDHLHFGATTQDIVDTAFVLAAREALRVLRRELLAVGDRLAELSQAQAQTLMPGRTHSQQALPVTFGLKAAGWLTPLTRHLERLRELEGRLYVVSFGGAA-GTLAALGDRGLAVADALAA-----ELDLAAPPTPWHTQRDTVFELAAWLAGVGTSLGKLAQDVILLAQSEVGEVREGGGGGG---SSTMPQKQNPITSEVILAAASTNAGLLAAVA-RSGVQEHERGTHGWQVEWLTVPQMLGLIGAALAHTRRLLDGLEVQAARMAHNVAASHGLMlaLTAVLPKEEAKALIrqALAGEGHLVGLVRERLGPRGARVdaALTEAHTLGSTFNLIDRAIRHYR
    295 UniRef50_B6A0Z2        Aspartate ammonia-lyase n=1...   246     1e-63  1  47.8%   6:298   5:297     -----RIETDLIGPLPIPANALYGVHTRRAELNFNVSGMRLSDFPELIQSMAMVKKAAALTNHDLGLLNAEKCQAICEAADDLIELNEIEHNFPVDMMQGGAGTSTNMNVNEVLTNIALHKLGAYLGDYSTLHPNDDVNLSQSTNDVYPTALRLTILRACDALVSSQVELRDAFRAKSYEFRDALKIGRTQLQDAVPMTAGQEFEAFAELIDEDISQVYAVCRLLKEVNLGGSAIGTSINVPTGFTAIACGHLSKISGLQVIPARNLIEATSDTGGYVSFSGVLKRIGALHGSLQIDI------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
    296 UniRef50_Q11FP8        Argininosuccinate lyase n=2...   246     1e-63  1  14.7%  41:463  27:442     ----------------------------------------IAQDIEMFDAYLAVDLAHVIMLADRGIIGPDPARALVGVLSKLRSDG--PASIKIDASFGGFLLQVERHIASV----------------SGPDAAGMLQLGRSRIDQNAAVARVYARNSLISVMNQLVDLQGVVLDRAREWKAVIMPGYTHLQHAQPWVLGHYLLGQHDVFQRDFQRLVGVYGRTNLGSLGGVALSGTS------WPIDRRYTAELLGHAGIVRNSKDAGNFVMDHQPELAAMLSILMSALGRLASELYIWSSWEFGLVE--LDESLCGTSSIMPQKKNPYALERIRALAGEAIGWLPGQL-GLFKTPTTSDCDRSFS--SGITPCFKATRWGLLLMSEALRTMRIDENRMRERAGAFWSTASNLADlrAHHVVGALVKTAVADGLRPSdvLSRSLDFTDEQISTALNSAEFV---------------
    297 UniRef50_A6X1U1        Argininosuccinate lyase n=2...   246     1e-63  1  17.3%  51:478  39:469     --------------------------------------------------FRRIDRAHLVMLTETGILDRAQAAAIAGALEAIDNEIDPSKL---------TYTGEVEDFFFLIEKELKARIG--------ADTAGRLHTARSRNDIDHTLFKLGLKARIDTLMTQARNLLDAMIAAAEREKETLIVAYTHGQPAQPSTFGHYLSAAVEVLIRDMERMEATRAIVNLSPMGAAAITTS------GFPIDRARVASLLGFA-APLPNSYSCIAAVDYITSTYSALELMFVHLGRLIQDFQFWTSFEVGQIYVPN--AFVQISSIMPQKRNPVPIEHMRHLASQTMGRARTVLDVMHNTPFTDMNDSEGETQAMGYEAFASAGRVLDLLAAFIGAIRIDPARVAENIRRSCITITELAdfRQAHEIAARVARAVVAMgaFRESAGREPSFGREKFEELVSPQHFvgPAPTAMNAALARHK
    298 UniRef50_B8D0M6        Adenylosuccinate lyase n=2 ...   246     1e-63  1  16.3%  18:478  11:457     -----------------PLDHRYSLKKD----LFNDLGKY-FSEKATIYFQARVELALVKALAGRGVCSFDVVKEVEEAVKGIKVGE----------------------VYEEEARTRhrALVNCIRKKISAEARPFVHLSATSFDIVDTANSLRYKEATEKLipALERLLEQWLNLAEQERDTLQIGRTHGQHAEPLTFGLVMAYYASRLHERIVNLEKVVSSL--CGKMAGAVgnASSLFFEDPEEFEKEVLKELGLKPAPVSTQIVP---PEYMTDYVHSLITVFGVLADFSDDMRHLQRTEIGETGE-YFAKDQVGSSTMPHKRNPINYENVKSMWKTFMPRMVTMYLDQLS-EHQRDLTNSASGRFIAEIASGLMMTVDRLY-KVSSRMKINSRKMKnnLSKNMIIAEPLYIFlgHPDAHEYVrkADKEGKDLVELIKADkkLDKRQKDILYNPEQYTGIARERTEEIVTKIR
    299 UniRef50_B1L394        Argininosuccinate lyase n=1...   245     3e-63  1  20.0%  35:478   9:418     ----------------------------------TEFISSIDSDRRIFRATVLTALAHQIHLFESGLLPKEAALTISLLLEALDKEDEILSRD-------------FEDVHEALESWVIERAGNL---------GGWLAYGKSRNDQVATALRYVTIRELISLLWEINRLRDSLIDAALMNLEKRIPAFTHLQPAQPSTVSHYLLSIEYELFHHYRSIWHvrEIVDLCPLGSGPAAGSS------VPMDRGRLADLLGFSGVESNTLL-ATGSRSFETIVLGILSSLMVVLSRVCEDLIIWSTPNFGLVELP--DDHVSTSSIMPQKRNPVTLEVIRAKAGEVMGCHFTVLSVMKGLPSGYNLDIQETNEPFLRAID-TTKGSLKVLSDLIRRSRFRES--ESEITLAQFIAEELVRRRgyREAHSiaSTLRESGWDLRKAVHSLGL----ELPSSYEVKVRGGPNPESLKGELEARR
    300 UniRef50_A7AM59        Adenylosuccinate lyase, put...   245     3e-63  1  13.5%   9:476   5:460     --------RDSIVHFVSPLDTRYRNSSSAIGEHL--------SEYALSRNRIFVEVSWLRFLVSEGLTNVTKLDESSDAYLSEICNFKPDDMGSITAIDKRV----NHDVKATEYYIRDKL--KSSGLPQLISLEPWVHMFCTSEDINSPAYSMGIRDCIEKVipTILRIIETVATFATENAGKPMLSRTHGQPASPTTFGKEFAVYVHRLSRQY---CKYLDQIDYMAKFGGAVGNFNAHKIAFPDKNWPDLAKdlHLSYQDYSTQIECH---DYISEVSDHISRVNTILKDLCVDMWLYTSYD---LIKLRGVQGEVGSSTMPHKINPIDWENAEGNIGLANSLFHYFSTKLPNSRMQRDLSDSTVLRNVGVAFCHSYLAYLSIL-KAFSRISVNESRALEELDANWVVLSelQIHlgYEKMLSLTRTGCVSKETMKDIISDNCG-NNTDLKS-LTPSKYIGYAESLALELNKR--
    301 UniRef50_B6KC85        Adenylosuccinate lyase, put...   243     9e-63  1  16.3%  18:478  27:489     -----------------PLDGRYAKKVaaAVSEFSLVQKRAFVMSE--------WLACLATNARVQRQSAADASESPAPFPSLSEEGKAaqMGRFSMDDVRRVKEVEKTANHDLKAVEYVLKGKLETSEATMPLAALTHFGCTSEDVNNLSWALCFKEATehLLPAVDDLAASLHMRAVEFAEVPMLSLTHGQPATPSTFGKEIANFEWRVKNAIKRVRDVEFRGKYN----GAVGCFNALVVADAKVAWPEVaeSLGLTYQPYSTQIEQH---DWIAELCDALARLNSILLDFSRDMWLYISRDVLKLRVV---AGEVGSSTMPHKVNPIDFENAEGNLELANALLRFLSTKLPVSRMQRDLSDSTVLRNVGVAFGHCLVAYES-AKKGLDRVDVNSEKMLKELDENWAvvQTLLRKRGVRNAYEKLKSAteRMQDIVETCSKDLLPEDLEILRSLTPATYTGLAPELAKKVGETME
    302 UniRef50_Q11KV9        Argininosuccinate lyase n=1...   242     2e-62  1  15.8%  15:463   3:440     --------------INVPDATRIGRATGAKaeLYDFDAAALTLTSAVFPYDSQIHRAHVVMLTEQGILTVEESATILSGLAQVDELAATDGSLRTYLPYEAALKRT------------------------IGSVAGKMHIGRSRNDLANAGKRMFLRDQLLRTIEAVIGYREAVVHKAADHLDTVMVVYTQRKEAQPITLGHYLMAISENLAKNLDRYRELYARINLCPLGAAATAGT------GWPLNRDRTSALLGFDG-LVVNSIEGVAGWDHVAEHAFVNAVFLSGLSRLASEIQLWSTDEY-QVAE-LDASFAGTSSIMPQKKNPDSLERSRKAAFAAMGPLVGILTSLNAIEYQYSAARVELEPRSIDALIAATHA----MTGVVRTLHPNKERMRQYAAENYSTMTDLTdgIDYREAHEIVAhaIEKGIkvQEAAVAQTgvSADDIKDALDPWQNV---------------
    303 UniRef50_B5WSC5        Argininosuccinate lyase n=1...   242     2e-62  1  17.0%  48:465  34:446     -----------------------------------------------LPLLTEINQAHVVMLHDTGLLERETASSLLAVVDDLAVAGPAAFTLD----------ASLEDVYFNYEAEVIRRLGQ--------DIGGRLHTARSRNDLQSTLDRMRARQVALSLIDGNLSLRRSLIRQATRYTDCVMPGYTHLQHAQPITYGFYLSAVERGLQRDFDRLLGAFHRLNECPLGAGAMAGTT------FPVDRHAVSALLGFS-APVAHALDAVASKDPLLELLCAALFVATTFGRLAQDFYLMSTFEFSTLTLP--DSLAITSSIMPQKKNQAVLEFLKGRQSHLLGALVTGFASFRAAPYSHALDSNADSLHWLWQAVDELVETIPVMDQVISRATPNSQRMAKLAGANFSTATDLADLlaHHITGRVVRLAIDAGLGVADIPPedISLSREEIADALDPRAAVER-------------
    304 UniRef50_Q12CF4        3-carboxy-cis,cis-muconate ...   242     3e-62  1  16.2%  42:441  18:404     -----------------------------------------FSERNFLDAMLRFEGSLARAQASVGLIPEAVAQSISGTCKVELFDVAK-----IVRESGRAGSIAIPLVKSLKETVGL----------FNKDAAGFVHFGSTSQDVIDTALALVTRNALNLIEADVHKAVAALLVLAGRHAADPVLARTLMQPASVTSFGLKCAGWAAPLVRSLQRLQATAGNALSVQLG-GAVGTLAQMQKAggPQVIAHMASELKLRA----PSCAWHTQRDEWVALGCELGLLVGSLGKIAKDIALMGQYEVGEVAEPTEP-GRGGSSAMPHKRNPVACMVALAAAQRAPQR-VAALLAAMPQEHERALGNWQAELAEWPGLLMSAHGSARAMAQALPGLQVDTQRMRANLDALRAVleWFSPGLARHAAELTQAQVLAHTQALAAL-------------------------------------
    305 UniRef50_B0U0M0        Argininosuccinate lyase n=2...   242     3e-62  1  16.3%  19:447   2:393     ------------------NKKLWQTETDKlvEKYTVGQDYI-LDQKLLKYDLQASLAHAKMLYKMKVITKDELNLLKKGLQEIQELLSNNEFRI---------TQDQEDGHTAIEQYL---------CTHYGEVGKKIHTGRSRNDQSLVMLRLFMIDKIQFLEKTIQENIYTLRSKASKFKNIPMPGYTHMQKAMPTTVATWLGSFADALADTLLLISATSKVINQNPLGS-ASGFGISNFKH----DKEYTTELLGFNRTQDNPIYCACSRGYFEKLALQTFSNPISIYSRFANDMMLFTMAEFDYFSLSN--SYTTGSSIMPQKRNYDLFEIMRGNAKLYQGYLQQITSIIDSVPSGYNRDYQLTKLPFFEAITLIEDTAL-LFNSTIKDLNVHIDKLEQAM--TPDlaT--------EEVYKLV----EQGLSFRDAYVAIKL-------------------------------
    306 UniRef50_C7M1W3        Adenylosuccinate lyase n=1 ...   241     3e-62  1  15.0%  38:476  10:433     -------------------------------------IARLFADEARLGRWIAVELAVTDALGALGEIPAEDAARLRQLAPTPDEAFVEAVNDR-----------------ERITHHDTAAFVDVLQARIADPAARWIHFGLTSSDVVDTALSLALVHATDRVLELVDGLADTLRVRALETRDLVCLGRTHGMAAEPTTFGAKLALFWLALERARARLVAARETISVGKL-SGAVGTYSALS----PAIERHALEALGLR----PTSATQVIPRDRHADVVWALAALGAVLETIALEVRHLARSEVGEVAE-PFAVGQKGSSAMPHKRNPVLAERLSGMA-RLARSAVVPALEDVALWHERDISHSSVERVMLPDAFHVACYGTSLATRIVAGLTVHPEAMAQNLAATRGLvlALvrGMARDDAYRIVQAAAaeDVPFLDALADDppLSPGELAELASAERLVANLAPLFARLEEA--
    307 UniRef50_C3RQ82        Adenylosuccinate lyase n=4 ...   241     3e-62  1  11.8%   6:471   4:460     -----RMEKQEFECLTlpLDGRYSGVKDALGEYF--------SEYALVKYRVFVEIQWLKFL-------------IENVESDVLAKFDLQDMDKLTTISSEFNYDSFARIKEIENTTRHDVKAVEYFIDEKVDALGfvHIGCTSEDINNTSYACMLKYGLKDvlPKAKEFAAIIDKWAEEHSNDAMLAHTHGQPATPTTIGKEFKVYAYRFLSSIENVEAVKIKAKFN----GATGNYSAILTAFPNEDWQVLaeYLGLTFNPLTTQIE---SHDYTCHILDGIRHFNNVLVDFDVDMWLYISMEY--FKQIPV-KGEVGSSTMPHKVNPIRFENSEANIDMSNNICIALSNKLPKSRMQRDLSDSSSQRNLGLAFGYSLQAINETMNG-LAKCVVNKDKLASDLNEKWelAEPIQTMlaYDTLKALTRGKSISKEDILKFAESLDILSDQDRQTLVdpASYIGLAKELAK-------
    308 UniRef50_C3XBD5        Adenylosuccinate lyase n=2 ...   241     4e-62  1  13.8%  18:473  11:475     -----------------PLDGRYVRKTGAL--------RPILSEAGFMRHRVKVEIAWLKALSKAGF---SEIRPFSDVTNKFLDALVNDFAVDDAARIKDIEAITNHDVKAVEylQARPITVDAIVTDELKTAAEFIHFACTSEDINNTSHGMMIKAARDEvlPALNAVIEQLRSIAHQNASLSMLARTHGQTASPTTLGKEIANIVSRLQRAAGKIAAVE----IMGKMNGAVGNYNAHFSAYPDFDWENFSrsLGLTFNEYTIQIEPH---DYIAELFDAIARANTILIDLNRDIWSYIS---LGYFKQITKAGEVGSSTMPHKVNPIDFENSEGNLGMANALLKHMSEKLPISRWQRDLTDSTVLRNIGMALGYTVLAYDSCLRG-LNKLEVNAERITHDLEDAWelAEPVQTVMryEQLKALTRGKGIEKQDLQEFIRNL-DLPQSAKNELltPASYTGIATKLAEKI-----
    309 UniRef50_A3MSF0        Fumarate lyase n=5 Tax=Ther...   241     4e-62  1  16.3%  18:433   8:383     -----------------PFDWRYGSEEVRA----------LFTPQAFIDAYVEVERALVCALEELGVAERGCCEAVGKA------------------------SVSAEEVYELEKKTGHDV-LSLVLLLEEKSGCRFVHFGATSNDVIDTAWALLVRRALGHIKRKVNAVGGELASLAARYRRLEMVGRTHGQWAEPITLGFKFANYYYELHIAC-RLLALAEDLMRAKLG-GAVGTMAAWGELG-PAVRERVAQRLGLPYHPISTQ---VAPRETFAVLASALAVLSSVFERLAVEVRELSRPEIGEVVE-----RGGGSSAMPHKANPTTSERIVSLA-RYVRSLVSVALENVALWHERDLTNSANERVWIPQAILAVDEILDSAARLLKSIHVDEGRIRENLEKALPYILtiKEGLPRAEAYKRAREVRA---------------------------------------------
    310 UniRef50_A8F694        Fumarate lyase n=1 Tax=Ther...   241     5e-62  1  19.4%  47:464  22:425     ----------------------------------------------MIDHYHQLNKAHLLMLHKCRILPDDVVFKIATGLKKLQ----------------------NEKVKELPENvlVLLFEKKLGDLIGEDVAGFLHTARSRNDIDATIFRMALRNVLIQFEKELLNLIKQFIRKAGQNIDTVFLLYTHGQPAQPSSFAHYLLAFSGELTQVSKKLIETFDIVNECPMGAGAITTT------GFSIDRNLVSNYLGFN-RPLENSYQAISTSHWITLPGALLRNLMIDITRFIQDIMHKSSSEVGVLQFPN--ELVQISSIMPQKRNPVVLEHLRLRANMAANAFSNIENVFLNVPYQdnENGDFVLREFLNAMDI-SNQVLILLSEMVEKVIVRTDRVREIAAqsTELADELVrgISFRKAHLIVSEVVKTGLNfkEHLKEKpeINPEEFQHILSCEHFIE--------------
    311 UniRef50_Q492R4        Adenylosuccinate lyase n=3 ...   241     5e-62  1  13.7%  18:470  12:453     -----------------PIDGRYYKQTD--------SLRNIFSEFSFLKFRVQIEIYWLKKLANTIAITepPFTQIES---DFLNKLTINFNIKDAERIKEIEKITNHDLKAIEYFLKEKI----NILPNLKKISEFIHFACTSDDINNLAYGLMLTNTKKTvlPIWKQIINEIKKMSINYKDIPVLSRTHGQPATPSTIGKEMANIAYRLIRQYHQL----KSIKILGKMNGAVGNYNAHVIAYPEINWRKFSEelGMKWNPYTTQIEPH---DYIAELSDCIARFNTILINFNRDIWGYIA---LNYFKQNHSNTTIGSSTMPYKVNPINFENSEGNLGLANAMFNHFSAKLPISRWQRDLSDSTVLRNLGMAMGYALIAYHSILKG-IKTLTVNKEHVLTELNKNWilSEAIQTVMRRHNIHE-SYECTKQFINNTEiiESLPLPATEKIrqKITPLDYIGLAAVMA--------
    312 UniRef50_Q83FF1        Adenylosuccinate lyase n=7 ...   241     6e-62  1  15.7%   1:472   1:457     MSED---EYDSLS----PLDGRYG-PAVRALRGFL-------SESALIRERIRVEIGWVFFLWR---------KAVFGLAEPTKEDERFLSSIVHDAHKNI------PRVKKIEERIQHDVKAVEIFLRelGNIVELLHFACTSEDINNLAYALNMKAAleVILPSIDELIGHLEKMSQKYAGDAMLARTHGQPATPTTLGKELLVFVYRLKRQRKNLEDVQ----FLGKFSGATGTFSAHCVAAPNYPWQEWAKefGLIYNPITTQIEPH---DWQCELLERVGHICRILHNLATDMWSYIS--FGYFQQGFISE-SVGSSTMPHKVNPIRFENAEANLEMACGIISCIVASLSTSRLQRDLSDSSVQRNIGVALGHSLVAIDNLKRG-LAGIRLNKNRLTEDLNNNWeiAEAVQTTIryERLKDFTRNKKITKHTLDEFITNL-DLSEHAKKRllTPSKYTGLAERMVQA------
    313 UniRef50_UPI0001AF22AB 3-carboxymuconate cycloisom...   241     6e-62  1  15.9%  43:476  27:477     ------------------------------------------DDRAWLQAMLDAEAALARAQSTLGTVPP--------GAAAAITEAARAELFDVRALALAARETANPVVPLVRELTRLVALG-------DPAAAEYVHRGSTSQDVFDTGAMLVSARVARLLLADLRRTADALYDLAAAHRDTPMAGRTLALHAVPTTFGLKAAGWRDLVLDAADRVAGVLEGGLPVSLGGAAggTSAGLdgGYLDALNGAFAAETGLARQRTP----WHSLRTPVADLAAALAFTTGALGKIAVDVQSMVRTEVDEVAE-PAVAGRGRSSAMPHKRNPVLATLIRSAALQVPA-LAAGLTQCMLAEDERSPGVWHAEWPLLRGCLRLAGGAAHTAVELAEGLVVRPDRMRDNlmASERVAAALASGLGRGRAQELLAEASatGRPLAEVLAALPglDPRVLSVLLDPLGYTGAAGPLVDRALER--
    314 UniRef50_B8LE99        Adenylosuccinate lyase n=1 ...   240     7e-62  1  15.0%  18:477  27:475     -----------------PLVSRYATKEMSAV----------FSPAMKFTTWRKLWLALATSEKELGiiSDEQLQQMKDNLYNI--DFAKAD--------------------EYESKFRHDVMGHVHAFGEVAeaMPIIHLGATSCYVGDNTDIIQLKEALKLVQRKLVQTIAILKDFAEKHKDLPTLGFTHYQPAQLTTVGKRCTLWIQDLLMDYERVTYELENLPMRGVKGTT-GTQanGDHDKVKQLNEKVCAMMGF--TKCVPVSGQTYTRKIDYHILSLLSGIAQSAYKMCGDIRLLAN--LKEVEE-PFAKNQIGSSAMAYKRNPMRSERVCSLSRYVMSLPPSAANTHANQWFERTLDDSAIRRIILPEGFLAVDVVLNLLMNIADGMVVWPNVVEKHVMEELPFMATEVILmeAIRVHSMAAGAVVKGedLMERIAADSLFAadKLDELVDPKLFIGRANVQVDDFLTDE-
    315 UniRef50_D2QE84        Argininosuccinate lyase n=3...   240     1e-61  1  15.6%  21:430   2:394     --------------------KLwgVSTAEQIERFTVGRDRE-MDLYLAPFDVLGNLAHAHMLETIGLLSTDELTMLNTELKTIYQQIQAGQFEIEE---------GIEDVHSQVELMLTRVLG---------DVGKKIHSGRSRNDQVLVDMKLFSRDRLWRVAEAVRTVFDRLVSRSEQHKDDLLPGYTHLQIAMPSSFGLWFGAYAEALADDMLTLQTAYRLANRNPLGSGAGYGSS------FPLNRSLTTELLGFEGMHVNVVYAQMSRGKTEQTALTALAAVAATLSRMAMDICLYNSQNFSFLTLP--DALTTGSSIMPHKKNPDVAELLRAKTNRLKALPMEVTLVMSNLPSGYHRDMQLLKEILMPAFDEILD-CLEITDFMLEHLQVKANLLDesVERVNELVLQGVPFraYRTVGKEIAE------------------------------------------------
    316 UniRef50_UPI0001AF729D fumarate lyase n=1 Tax=Myco...   239     2e-61  1  15.7%  39:464  25:429     --------------------------------------RAILGERGLLARFLQVEAELAAAQADLDMIPAEVAPALRAV---------TPDHLDIARLAARTQAAGYP----------IVGLVEQLAAIVPDGLGQYAHWGATTQDIMDTAAVLQIVAALDVIERDLLHTLAALTTLETQHGSELMVGRSQLQHALPITFGYRVACWTAPLLRHLDRLAELRPRVAVVQLG-GAVGSLASMAPHGLDI-RRELARRLGL----AAPSISWHATRDRFVEVVAWAAQVAASLGKIGLDIVVGSQTELAELSEPSAPGRGV-SSTMPQKRNPIGSQQLI-RAARLTRSYLDLALDGAVADCERATAVWSLEWHTVAPALAVCGGAVRTAADVLAGLHVDSAAMAANLdmAESVMMRLAPVLGRQAAHdlVTASLESGESFATLVARR----DPKLADAVTPAAYLG--------------
    317 UniRef50_C7LJX3        Putative fumarate hydratase...   239     2e-61  1  34.3%   5:412   3:376     ----FRIEKDSLGTIEVSNKKYWGAQTERSKINFKI-GKKYSMPIEIISGLAYLKKAAAITNYELGFLSKKKKKIITKVCDEIL-EGKLNNNFPLVIWQTGSGTQTNININEVISNRAHVLSGKKLGEGIsiNPNEDVNKSQSSNDAFTTAMHIayKILIEKTIPGIKKLRNSLKLKSFDYKNIIKIGRTHLAP----SLGQEFSAYVSQLDKVIKELKNIINNILELAC-------------RFDLKVVNYISNLTGFEFKTAKNKL---SSHETIVITHGILKNLAISLFKISNDIRMMSS--VIGDGEIIIPSPSG-------KINPIQCEAFCMVSIKVIGNDTTISLASGSG-----VCKPVIGSNFLESAKLIGEACFSFSKNCISGINPNIPRIKKLLNQSLNLI------------------------------------------------------------------
    318 UniRef50_B0R3B3        Adenylosuccinate lyase n=10...   238     3e-61  1  15.4%  18:471  12:456     -----------------PLDGRYSGRTDAL--------APYVSEAALMRARVEVEAEYVLALADLDAVPLELVGDERTALRDAYKTFDAADADLVKRIETEGALGHAATNHDVKA------VEYFLREHAPARAHSWIHFGLTSEDVNNLAYRLLVDGAITAVlpELRGLRDDLVSFAHDYADLPMLARTHGQPATPTTFGKEMAVYAARLGRALARITDAVDGLT--GKLAGASGTWAAHTAAFPDVDWRSFAArlGLAYAEPTTQVNPC---DDLTAVFDAVAGANGVLEDLAVDAWLYVSQRYLG---QDAADGETGSSTMPHKVNPIDFENAEGNLAKANSDLGFLGDSLTTSRLQRDLSDSTVKRNIGAAFAHCLLAYRKLGDG-LDAVTPNEAVLREDLRANPEVIGEAVQTigHDDAYERVKALTRGErdFKELF-ASLDIDADTRDEllTPERYVGVAADIAR-------
    319 UniRef50_D2R2V1        Adenylosuccinate lyase n=6 ...   238     3e-61  1  14.2%  18:475   9:453     -----------------PLNTRYASAEM----------SRLFSDQRKFSTWRRLWVILAEAEHEMGlvSREQIEEMKAQVDNIDFQVAAA----------------------YEKKLRHDVMAHVHTFGDLCPGapIIHLGATSCYVTDNTDLILMREALELIARRLAVVIDALGKFATTHRELPCLGFTHLQPAQPTTVGKRATLWIYDLALDLAEIEHRIESLRARSVKGTT-GTQASfdHAKVRQLEAMVAERMGFSGSYAVTG--QTYTRKVDAQIVDTLSGVAQSAHKLASDLRLLASRKEM---EEPFEANQIGSSAMAYKRNPMRSERVCALARFVMSLQSSPAATLATQWMERTLDDSANRRLVIPQAFLGIDAVLLLLTNISSGLVVYPKTIAANLnaSENLMMAAVERGgrQELHEVIRAHsqEGKplLERLRGEPAFAGVDLAAAMNPRDFVGRAPEQVDEFVA---
    320 UniRef50_B2SEM1        Adenylosuccinate lyase n=19...   238     4e-61  1  14.9%  40:462  12:409     ---------------------------------------KIWADENKYAKMLEVELAILEALEDR-MVPKGTAAEIRARAQ-----------------------IRPERVDEIEKVTKHDIIAFCTSIAetAETGKFFHFGVTSSDIIDSALSLQIRDSMSYVIKDLEALCDSLLTKAEETKEIITMGRSHGMFAEPMSFGQKFLGAYVEFKRRLKDLKDFQKDGLTVQF-SGAVGNYCILTTE----DEKKAADILGLPVEEVSTQVIP---RDRIAKLISIHGLIASAIERLAVEIRHLHRSDVLEVYE-GFSKGQKGSSTMPHKKNPISTENLTGMARML-RSHVSIALENCVLWHERDISHSSAERFYLPDNFGIMVYALRRMKNTIDNLVVQRDIIEDRVRSTSAYLSSftPFM-REDCYKIVQQvlKQGESF---SKKLQKVMHDEHNIILDILEM----------------
    321 UniRef50_Q54J34        Adenylosuccinate lyase n=59...   238     4e-61  1  13.1%  18:469  17:466     -----------------PIDGRYWGQVQVLSEYF--------SEYALIKYRVQVEIEylSKLSELKPLNAVNKEDDHKKLRDIYLQFKESDAQKIKQIE----KTTNHDIKAVEYFIKEKM---HTELQYSEVVTEFIHFGLTSQDINNTAIPLSIVESVEklIPQLKQSiePLRQFAQQWKSIPMLARTHGQPATPTTVGKELMVFIERLENQINHLEQSVPHTCK---FGGATGNLNAHKVSYPAIDweKFVKVLhlKRMRFTTQIE---HYDNVASLLDAFKRINTILIDLCRDIWTYISMEY---FNQKLVKGEVGSSTMPHKVNPIDFENAEGNMGVANALYEHLSAKLPISRLQRDLTDSTVLRSIGVPFSHSILSFKSIQRG-LSKLVLNEANIAKDLDANWAVveAIQTILryEALKELTRVSGSKKITESDIQTFIDSLspDDIkkLITPFNYIGIIPDF---------
    322 UniRef50_Q981V0        Argininosuccinate lyase 2 n...   238     4e-61  1  13.6%  18:464 438:867     -----------------PGEGRWALHPEAMKLLAP--PIEISRDGRLLQHQAAIDEAHLVMLADQGLVSQAAAADLLKHILDLQDEG-------FQSLEGRDAPRGVYLAYEAE-----------LAARAGPEKAGWLHLARSRNDLNATISLLVLREAACSISQQIGIAQGALLQRVEEASSLVAPLYSQYQIALPGSPGHYLLGVFFALGRERQRLHSLLEDIRNCPMGAGAGGGTS------MPIDPLKTASLLGFE-EPSFNSLDAVASRDHHLHGLSIFASISTLLSRVAQDLQVWTTREFALIDVPRN--LAGGSSMLPQKKNPFLLEHIKGSASTVIGAYVSAATATCKAPFSNSIEVSNYGCSPLRLSEEALQRALILTSLIVKGMSFNVRSMRDHLEDGSS-MTAIapFREAhqIGEIAQrcATQRRS--ELASQLAGVFPVSLEECRDALQFGG--------------
    323 UniRef50_C0QI65        PurB n=1 Tax=Desulfobacteri...   237     5e-61  1  14.3%  19:478  18:463     ------------------LDGRYKALTVELGE--------IFSEFGLIQHRVYVEIEWLKflKDLALVKVDPF--LLEKLDRFTIDFTEADAAVVKKIER----TTNHDVKAVEYFVK-----ERLESAGLSPLKEWVHFACTSDDINNISYALMLKKGKKVVADFLETLLKALEETGLKHKSVPMMGRTHGQPATPTTVGKEFINFAWRIRHELFILQGATVQAKIN----GATGNYNAHYFVYPEIDwrFLGQSLGLEPLLFTTQINPNASLSFIL---HSLVRSAAIIIDFDRDMWGYIS---LGYFRQQLKAGETGSSTMPHKVNPIDFENSEGNMGLAIAMMDHLAVKLQKSRFQRDLSDSTVLRSLGSALGYYVIGVKNALKGM-GKIAVDPSAMVRDLEANPelAEPFQTAMryERLKDLTRGKRIGRRELDGFVDGLEKV-PEDFrkALSVPQYTGLAEHLVDLYFQREK
    324 UniRef50_Q8TXN9        Argininosuccinate lyase n=1...   237     6e-61  1  21.2%  33:461  20:435     --------------------------------DFAELSSSLEQDREIFHCDVWNSVVHAVSLWEAGRIDRSTAAGIVEGLVTVLEEG--PDRLPEDA----------EDVHEAIESRLHEVVG---------EEAGWLQLGRSRNDQVATSVRMRLRERALDLSRELVGLGRALLDLAREHAEVPIAGYTHLKRAQPCTIGFWMSTYAAAVARSARGLLRV-PGMDECPLGCSA------FPGSTVPVDRHREAALLGFR-KPARHCGEATALRGPILEFLGRLATAASELTRLAGDLIQLCSDELGVVE--PPDELSSTSSVMPHKKNPDALELVRAELTVVAGLKGLGDAVHGKLPMFYNRDLQVLNGLLWDSVNRF-ELCVRVLRKVVEGLDVDEEAARGTVLGSHAAAVDLAefREAHkvGRVSARLDREGVPmeELEREGVKLRVEEVREVLSLKR-----------------
    325 UniRef50_Q1M9E8        Putative fumarate lyase-fam...   237     6e-61  1  45.2% 185:456  57:326     ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VKVGRTQLQDAAPVTAGKEFEAFAEFIDEDIVQVHYASKLLKEINLCGSASGTAINVPSGFAQAVCDHLSQKSGYRLIPARNFIEATSDTGGF--VSFVLEGIAFNLTKICNDLRLLSSGPRGGLGEIRLPPVQAGSSIMPGKGNPFIPEMMNQISFQVIGNDLTVTLAASAGQLQLNAMEPVIVLNILQSMRMLTRGMVILMERCIDGIEVDVDRCQALLDQSIVLAKPLAKLIGYSKAADLTKKALVEKRNLRDVVEEERGLTESQVHQI----------------------
    326 UniRef50_A8ACF4        Argininosuccinate lyase n=1...   237     6e-61  1  14.8%  29:454  13:403     ----------------------------RWLADF---ISSLHFDKDICPYVIDVLIVHINELERKGYVSSEDAKTLKELLEQFDCSADFD---------------GYEDIHEAIEYYLIERTG----------AAKQINLGKSRNDQVATAIRLRVREELLESATALYHLLKALYAKAKLHEEVFFPTFTHLQPAQPANFGLFLTNFAEEIVDSFGLLEVALEITDKCPLGAAAAAGST------VDLDRRRRCEELCFKDLAYNTLY-ATTSRDFALVSLGALASLSIPLLRFVEDVFVYATPPFSLIRVPLDHAG--TSSIMPHKKNPATLEVVRAELSKLLGHYVSAFSILKGLTSGYNLDLQQLT-PLLWQAFKTFRKSVIVITDFLWKMEVNEERAKEFLrlAADLAEYLvkGLTFRDAYATVARALKEHND--DLARAAEGLVGDEWK------------------------
    327 UniRef50_Q1R0U7        3-carboxy-cis,cis-muconate ...   237     9e-61  1  16.3%  37:478  14:444     ------------------------------------TGREKCSAQDLVVAMLDVELALAAEQERLDMLPK--------GTTETLGEYLTTEVFDIEALADDTAKGGNAAIPFV----------KQAKAALPDTLKPYFHRGATSQDIVDSALMLLLKPRLARCRRLLTASIDDGRSLMVAHRDTTMIGRTLMQQALPITFGAKVGQWAWGLHQAGERLDDVLTGGLYVQFG-GAVGVHSGLDDAGVAIM-TGMASRLGL----AEPWLPWHTDRQPIHSLGCAIDAVAVAAEKVALDVALLTQTEIGELAE-PAEAGVGESSSMPHKRNPVGCARIRAAARQIHAAL-SVLTNAGAQPLERGLGEWHAEWAPMLDAALLLEGALETLQHLLSGLEVNDQVMARNLGVTGGAIMalQSILSNDEARRVAREASEngVDYAEALLAhsAIDADALRQAVRPESYIGSSRCLVERVIERLR
    328 UniRef50_A1QZL0        Adenylosuccinate lyase n=10...   236     1e-60  1  14.9%  18:474   7:453     -----------------PLKSRYASKEM----------LYIFSPKFKYTTWRKLWYNLALVQKELGiiSNKQLNKLSKHIENI----------------------DFELVKKYESKFQHEVMAHLYAYADLadARKILHLGVTSAYLMDNTDLVQIKEALLLIENKLLKLINTLKKFSIKHKNLVTLAYTHLQEAQLTTLGKRSSLWLQSLIFDFEELKFIMSNMRFRGVKGT-VGNQSSFKELFASNFEKvlAKKMGFDKVYQITS--QTYDRKFDSSILNFLSNLAQSAHKITNDIRFMQH--LKEIEE-HFEPHQIGSSAMPYKRNPIYSERIASLAKFIMSLQSSGGFIAATQWLERTLDDSACKRLNIPQAFLAADATLILLSKVFNNIRVNKKMIEKHV-KTEmlMKATKNGGDRQILHekVKENIYSGTTENDLIkqSFKLTSKDIDEILNPNENIGFASYQVENFI----
    329 UniRef50_Q3IME1        Argininosuccinate lyase n=1...   236     1e-60  1  16.4%  40:477  28:452     ---------------------------------------SLAADERIFEADLAVDRAHVVMLDEQDIIGTDDAAAILGALDDVEA-------------AGHGSLTDGEDVHAAIETAVIERVG---------DRGGKMHTARSRNDEVAACIRYRLREDVLAAVEATLEAREMLLDVAGDHTETVMPGFTHLQPAQPTTVAHYLHSYASALARDTERLLDAYGRINRSPLGAAAFAGT------PFDIDRERTAELLGFDGV-VRNSMDAASARDFLVETTAAAAGLATTLSGLAEDLVVFSKAGYVEL----DDAYASTSSIMPQKKNPDTMELVRATAGDTAAGLNALLTILKGLPRAYNRDLQRAHPHAFEALDAVTEA-TEVAAGAVATADWKEPALSEAAGEGFSTATGVADLLAMetAHELVARAAEAGGDYAALSAAAEDidKAAVEAALDPESSvgPAPESMAAALSAA-
    330 UniRef50_Q11FS3        Argininosuccinate lyase n=2...   236     1e-60  1  15.1%  20:477  20:469     -------------------DARLGKKPADRLQR-HYLQATLKREENKFDQIIAVDQAHAVMLTEQGIIPRATGTALLVQLSKLRREDVGID---------------------VMRGSMLLQIEGHLASKTGNEAAGALSTGRSRIDQGATFRRLYERQAIIAVLTELIDLEAAVIAQAANHIDTIMPGYTHLQPSQPWVFGHYLLGVAERLDIDLVRLERAYAAVNLCPLG--TVGGSGST----WPLDRHRVASLLGFDGIVEN----ARLGRdyTGDIAAAASMLMATLNDLATDLQLWSMQEFGFVE--LDAGYCGTSSIFPQKKNPVALEGVRSAAAGAVQWVGNVLAVSRGVG---SGDLALRGAAFLDTALQSTAQMCDLMTGVMETLIVHKDRMAERAGEGGTTASNLADTlaHHAVGRFVRVCLERNLPLTGvlADQPRLSDEQLAVALDPAGFvgVAPEEVARLHAAA-
    331 UniRef50_B2KEG4        Adenylosuccinate lyase n=1 ...   235     3e-60  1  14.2%  18:474   8:463     -----------------PLDGRYKSKLSAL--------SHYMGEAALSGQRVNVEIEYFKALAGLGLKNFPKLKESEVKILNSILPLSEADLVTIKDIEFRGykATNHDVKAIEYFLKLR-----LGASSLKNRLEWIHFALTSEDINSISYALMLRDGVevLLPELKKIHKELTDLSKKYASTIILARTHGQAAVPTTFGKEFKVFEYRLRRQIKQLE---KQQISCKLG-GAVGNFNAHFAAFDKVNWHSFAkiSGFnlNEVSTQID---SHDTYAELFDNVKRANTILLDFCQDMWRYISDDYI---KQRPVEGEVGSSTMPQKVNPIDFENAEGNIGLANALFGYFSSKLPVSRLQRDLSDSTVSRNFAVAFGYSVVAYSAILKG-LGKISVNTQKCAQALHEHPEVLAEGVQTipYEKLKALTRGKKIDNEVLRRFI-EDLDVSKEVKDKllSLEQYTGIAAKLAKGLK----
    332 UniRef50_B9KWU3        Adenylosuccinate lyase n=1 ...   235     3e-60  1  17.0%  37:477  19:448     ------------------------------------GSRELFAPEAVYQAWLDIEAAVALVQGEMGLIPAEAAATIARTARVACLDMERVERDYVRQRHP-----------------LMPLLGELVRK--CGEAGRYVHWGLATQNIQQTGTLFLALRGHRILLAVLDEILGHLGRLATAHADTPMAGRTHGQHAVPITLGFKFAIWIDELLQARERLRSVEARVFTVTMG-GAVGAFSALGARGPE-MQDRVAERLGMHSMSLPSR----SNRTHMCEYVQLLALCASSFHKIAEEVAQSSSVEYAELFEVHSDGV-IGSSTMPQKVNPKISMGLMANCQKLYA-LSSMMLQTAHRPFEGDACANVIYDNGTAEAMELATAIFIRAEALVAGLRADPARMEENLHssESIMMKLAPAMGRGEAHDLVYRAAMESRefFERLSeaEILFEeqGRPRLKAEGHFGLSPEIARDFGARA-
    333 UniRef50_Q8K9Q7        Adenylosuccinate lyase n=31...   235     4e-60  1  11.6%  18:474  11:456     -----------------PIDGRYSNSTKLL--------RNIFSEFGFLKYRLYVEIQWLKKLINMHQI--LEIKKVEKTDILFLDNIFETFNEEDAISVKNIEKETNHDVKALEYFLRKKL----SQSKKLSPFLEFVHFLCTSEDINNIAYALMIKNARDEilPLWKKIINFLKNASFQYRNNSLLSLTHGQPATPSTMGKEMVNFYYRMQRQYHKL----KKIEILGKINGTTGNYNAHLVAYPKVNWHAVSKelGIFWNPYTTQIEPH---DYIAELFGCVSLFNNILIDSNRDIWGYIS--LNYFKQKLIDQ-EIGSSIMPHKINPIDFENSEGNLGLSNALMNHMINKLPISRWQRDLSDSTVLRNIGVVFAYSIIAYNSVLLGT-NKLTINTSQLLKNLDNNWslSEAIQTVmaYEKLKKLTRGKKIEKVDIHKFIDKlpKIEKERLKKI-SPSNYIGAASQIIDEIK----
    334 UniRef50_D1C6A6        Argininosuccinate lyase n=1...   234     4e-60  1  13.9%  19:434   2:395     ------------------ATKLwgYDLNPEIEAFEVGDDVVY-DNRLILADVLGSIAHAAGLTKVGLLTRDEFAALRSALAAIAEEAAAGTFRV---------EPGDEDVHTKIEHALTARTG---------EPGKKIHTARSRNDQVIVDLRLFLKQEAPRVERAILDCADALLSLAERHRLTPMPGYTHMQRAMLSSVGVWAGAYLEALLDDLTLLDAALDLNDQCPLGSAASYG------VPFPIDRRYVSDLLGFRAPQRNVLYAQNARGKFEAAVVQALSQVMLDLSKLAQDILLFTTAEFGFF--TIGAEFTTGSSIMPQKKNLGAMEMLRAKGSVMLAYQQQIMTVLAGLPSGYNMDYQETKRPFIDALDLTARAA-RVAALTVRNLEPNEQALLAAcdAAYELVAEGVPFRD---AYRRVGTALET--------------------------------------------
    335 UniRef50_Q1AVN7        3-carboxy-cis,cis-muconate ...   234     5e-60  1  16.4%  46:478  23:443     ---------------------------------------------AWLRAMLEAEGALARAGARAGVVPPEAAEEISRRCRELELDPEELGERGRA------------------AGNPVPALVKELTAAVPGEAARHVHRGATSQDITDTAAMLISREALGLILRELDGVCAACARLAEEHRETLVAGRTLLQQALPTTFGLKAAGWLVAALEARRVLREARERGLAAQLGGAA-GTLASLGERGTRVLREY-ARLLALP----EPALPWHAARFRVAELGGALALAAGTLHKVALDVILMAQTEVGEAAEPSGGGRGGS-STLPHKRNPILSVVASANARRVQ-DLARTLYGSLAQEHERAAGAWHAEWEALSGALALTGGAAAAVREALEGLEVRPGRMAENLAVTEGLILAeaERLGRLEAHELvrRVAEGGGTLREEILAEPrlSEEEIEGALDPARYLGAADEFVDRALEMYR
    336 UniRef50_D2KUG3        Adenylosuccinate lyase n=2 ...   233     1e-59  1  15.7%  18:475   7:455     -----------------PLESRYASKEM----------LYIFSPKFKYTTWRKLWYNLALTQKELGiiSQEQLDKLKKHIENI----------------------NFEVVEQYEKKFKHEVMAHLYAYADLadARKILHLGVTSAFLIDNTDLIQIKEALFLIKNNLKNTIKTLNNFSIKYKSLATLAYTHLQEAQLTTLGKRSCLWLQSLIFDFKELNFILSNLCFRGVKGT-VGNQSSFKELFSSNFEkrLAQKMGFNKVYAITS--QTYDRKIDSSILNFLSNLSQSTHKITNDIRFLQH--LKEIEE-HFEEKQIGSSAMPYKRNPIHSERIASLSKFIMSLQTSGGFIAATQWLERTLDDSACKRLNIPQAFLATDAILTLLNRIFHTIKVNEKIIEQhlLTEDILMKATKNGSDRQILHEkvKENIYLGknLIKLILNDkkLTPKDIDEILNPNENIGFASSQvdFIKE---
    337 UniRef50_UPI0001B4C156 argininosuccinate lyase n=1...   232     2e-59  1  17.6%  20:463   7:436     -------------------DGRLGASPAAALVD-HVNAVELDDEVAAAEHFAKIDLAHALMLTQQRVFAPEQGRPLVAALLRLL---------DGDAEKVLAGDAAVGTITLQLERHLEEECG---------PAGLDIQRARSRIDQKATGVRMADRAALLHVMRELLRLGEVLLDAGAAYDAVIAPGYTHLQHAQPTTLGHYFNAHYWTVSRNLARMAQLYERLNECPLGGAA------HSGTDWPIDREATAAYLGFARPVRNARDAGLSALDAGAELAAVLGLTLSGVSRCASDLFYWSSSEVALVR--LHPSLCGTSSMMPQKRNPIVLERIRGLAGDAAGWTASQLGVLHFATSTD--ADQGYVHNRMPGYCHETAGAIHLLAQSVATLEVDAERLRRSAERHWSTASALAdfRDAHevARFVTAHEAAGATEGTidLADGPltPDQLRHLLDVQSFV---------------
    338 UniRef50_A8M4P0        Fumarate lyase n=2 Tax=Acti...   232     3e-59  1  15.5%  39:477  27:471     --------------------------------------EAVTSDEAWLAAMVEFEAALATAQARLGAVPDGTAAAIRAAGESGRLDLVELARL------------GREAANPVVGFVKHLT---GLVASTAPEAAGHVHAGSTSQDVLDSAAMLVATRALCLVRDDLARIRTALTELARDHRGTAAVARTLTQHAVPTTFGTKAATWLTLICDAHERVNALLRQGLPVSMGGAA-GTLAAYHDHLTarLATLVADELGL----ARPTLPWHAARTPIADLAAVLNFVGGALGKFAADVLVLSRTEIAEVAEPAAV-GRGQSSAMPQKRNPVLSVLVATAARQIP-VYALVLGQSMVAEDERSSGAWHAEWQPLRECLRLAAGASHTAAELAQGVVVATERIRVNLSLTGslSVALGQELGRQRAKEAVTRAVRDTeaLRHALNEAGLVDgdSLDELLDPEGYLGAAAPLVDRAVHRA-
    339 UniRef50_A5G255        Fumarate lyase n=1 Tax=Acid...   232     3e-59  1  14.6%  41:471  16:434     ----------------------------------------LFSRQSVWQSWLDVESALAATQAELGMIPAEAAREIAARARLETIGEAALAADIAKTRAP------------------VVSLVRLLSRACAGEAGGFVHWGATTQNVVQTGRVLLMRRAHAALMRRLAAILDRLAGFAEAEAGTVTVARTNIRHALPITFGFKAGGWIEEFLRHEERFREAAPRVFRAQWG-GAVGAMHAVGEAGPELNR-RLAARLGLGWHEIPSR----AGLDTFAEYVLLLGMFAATCGKIARDLYVMMSDEFGEVIEDLGEEV-IGSSTMPHKVNSKIAVHVIALSARV-RAQVPLALEAMQPSFEGDGANNQMLSALIDQACPLAYELAAQMDELLAAIRLRPAAIGRNLAMSGAfmMALAPLLGRTVAHDIvaEAVETGGDLATLIAAAprVDAAMVRDALDPSSYIGQSVALAR-------
    340 UniRef50_Q08Q17        Argininosuccinate lyase n=1...   231     3e-59  1  17.8%  61:475   1:419     ------------------------------------------------------------MLARRGILAPEPAARLLSLNRELAHRLASGEELFPPPPSHRG---------------LYLLYEGEYISRLGGEVGGAAHVARSRNDINATVTRMRLRPALAEVLRQGMLLASQLERLGVAHAQTLMSAFTHLQPAQPATFGHYLGGVLSELLRTLDWIAGAYDTLNRCPMGAAavGTS-------FPIDTTIVAELLGFES-PLGNSLDAVGSRDYVVQVLSGLALLGTLLTRMSADLQTWASSAYGFLGWP--DELVSTSSIMPQKRNAFVLENIRGQAVKATGFLMNTLMGLKSTSFTNSVEVSSEATSPVWPALEAARTALVLMELLMSNVIVQPEPMRRFLVGQDTTMTALADHlaHDVVGRLVNLKREPELtlATTLGREVSLDEAELAQVLEPEGCvgPAPEAVRAHLA---
    341 UniRef50_Q02CF9        3-carboxy-cis,cis-muconate ...   231     6e-59  1  13.4%  40:478  18:427     ---------------------------------------KVFSDTSVLQAMLDFEAALARAEARCGVIPASAVTA-----IAAAAIAEGFDLSELTRLSLRAGTPAIPLVKMLTARVR----------AIDPVAAGFVHWGATSQDVADTALVLLLRQAVPILQADHERTMAALHGLSERNAGAVMLGRTLLQPASPVTFGLKAAGWYAALRRGWDRVSSRFDEALCLQFG-GASGTLASLDDRGMS-VGEALASELALREPDAP----WHGYRDRLAALMAALTIYTATLGKIALDVALLMQFEVGEAFEPGGEGRGGS-SSMPQKRNPTACMLTLAAAKRVPGLL-ADFVVGMVVEHERALGGWQAEWPLVYGIVQSAAIALESMAEVCDGLNVDVAKMRANVESTKGAIFalTPELGREVARRQVEDAIRETG------------SPPDLPGLRDPEQYLGSAEAFRKRQMQGDK
    342 UniRef50_Q89AM3        Adenylosuccinate lyase n=2 ...   231     7e-59  1  12.8%  18:471  11:451     -----------------PIDGRYSSKV--------IKLRNIFSEYAFLKFRVTIELLWLKKISLLQEFKIVYNKDVLNCLDRIIDNFSKKDALEIKILE----KKTNHDVKS-IEYFLQKKIFKCLGNH---DILGLVHFGCTSEDINNLAYALMLksRRDIILPLWNKIIFEIKKIALLHHNVPMLSRTHGQPATPSTIGKELINFAYRLERQLKQF----KNIEILGKINGSTGNYNALHFSHSSVDWHKISQelGLFWNPYTTQIEPH---DFISEFFSCLARVNTILINFNRDIWGYISLQY-FNQTPKLDE--IGSSVMPHKINPIDFENSEGNLGLSNAIISHLIEKLPISRWQRDLSDSTVLRNVGTVIAYSIIAYDSIILG-LKKLKVNTSRLLQDLNHHWelAEPIQTVMryNELKNITRGKRVT-SDIILKYVNSLKIPRNEKEKllTPENYLGLSSKLVK-------
    343 UniRef50_D2RAU9        Adenylosuccinate lyase n=1 ...   229     2e-58  1  14.6%  17:474  13:480     ----------------TPLDGRYHNQTSTLVEYL--------SEPALNRERMRVEVEWMILLAN-GY-EANQFQPIVKGVNPLTDEECspENFDAeaRHAAHEAITHHDVKAVEYYilDEAENKLGHATELSNLKTLVHFSCTSEDINNLSIARCVKQalNVYRPNLEAIVDYLVKNANEYRDLSMLSLTHGQPATPTTLGKELAVFAYRLRRQLRHL-DTQEYLGKLN---GATGTFGAHLAAFPEVDweFVENRMGLQWNPLTTQIE---SHDWQAELYSTVSHINHILHNLAVDVWMYISR---GIFVQVPVKGATGSSTMPHKVNPIRFENAEANLEISCSLFDTLCATLTESRWQRDLTDSTTQRNVG-SAFGYALLALNNLLGGLKSIHPNKEFMAKELDENWEvaEEIAGvrPYEQVKELMRGHHISQSDVEEFIKSRNFDANTAArqAMTPESYTGFASQLVDFID----
    344 UniRef50_C3BDI7        Argininosuccinate lyase n=1...   228     4e-58  1  14.1%  45:478  38:464     --------------------------------------------QYFLNGYILIEKVMLLEYQRMKLIKKKSVDEIFTLLNQINQETLCADL-----------TNNMSDIAFAIEQFVNQRI---------SEPVPAWHMDRSRNDFQACAQLMFAREQVFLIIEDLFEFIDVVHHVSELTSSMLMPGYTHYQAAQIISPGFYLSAVTEQVIELLKNLLFIYNRINKSPLGSGAMSGLE------LEWDRQNMAKMLGFDNIQ-NHALISVASREWALRVAGELSTFSVFLSRFVTDLIQWGSGEYGFIDLP--DQLSGISSAMPQKKNFTILERIRGKTSHISTYYLDLIMGQRNTAFTNLVEISKEANSNLITLFKTTRSILKIFTTVMENIEFKEERMKEICIngFALalTLHEGIPYREAQAIvkPSEVNYKLLEQVCQDQGylSENLIRKAFDpqNLIGKNTAGATSPKEVMK
    345 UniRef50_A6G9Y4        Argininosuccinate lyase n=1...   228     4e-58  1  17.2%  33:461  17:426     --------------------------------KFLEWQTSLPVDRRLLEVDVAGSVAHVEGLVAGGLVTREEGDTLQAALRSL----------PGKVARGEVELPLEEDVHMAVEVWLRATVG---------EVADKLHTGRSRNDQVATDLKLWVRSAVNRLLAGLEGLEAAIEAWNEAQGDTPMPAYTHRQVAIPVLARLWiaALGEPLARDRRLLAVVEDEIADSPLGAGAIGG------NTLPIDPWVPARELRFSSPP-RNPMDAVGSRDHGLTLAFACARISQHLARFCADVVELSSDGLVTLS----GAVACGSSMMPHKRNPDLFELVRGQAALRQGELVALMTTFQGLGTGYHRDLQQDKQVLFACVDGTV-ACLEMIALGIRNLELMPERCVTALERGDAIATDLTEAlaYRQIGALVATQRAAGKRLVDLRAEELEAapASLLDHLDVKA-----------------
    346 UniRef50_D2Q9D5        PurB Adenylosuccinate lyase...   227     5e-58  1  16.0%  17:473  17:483     ----------------TPLDGRYHQQTAPLVEYL--------SEPALNRERMRVEVEWMILLAneGNGFKTIVPGIKPLTDEEQarAIPEDFGAEGIAQHAAHEatHHDVKAVEYYilDKAAETLGHETQLTELKTLVHFACTSEDINNLSIARCVKNGIENvlPGAQAIVDHLAEKAEEYRDKAMLSLTHGQPATPTTLGKELAVYVYRLSRQLNKVRNQE----YLGKINGATGTFGAHLAACPDVDweFVTNRMGLTWNPLTTQIE---SHDWQAELYGTISHTNRILHNLCVDVWMYISR---GVFAQVPVKGATGSSTMPHKVNPIRFENAEANLEISCSLLDTLSATLVESRWQRDLTDSTTQRNIGSALGYSVLALNNLMGG-LNSIHPNDIAIQAELDANWEvaCELAGLPGMDKPYEKVKE-LMRGHEISQDAVER-FIDEQSFDeaLTPATYTGVASRLVDFA-----
    347 UniRef50_D1BFI0        Adenylosuccinate lyase n=4 ...   227     5e-58  1  14.7%  18:474  26:488     -----------------PLDGRYRSTVAPLVDHL--------SEAALNRERLHVEVEWLVALTdtPVVPG--APSLSDAEKAYLRDVVATFSGDGIAEMAEIERETVHDVKAVEYFLKRRLAAalGDATVLPGVGELVHFACTSEDVNNLSYALMVRGAVQQvlPAATALVEQISEMAREHASVPMLSRTHGQPATPTTVGKELAVLAHRLRRQVRRVEGAE----YLGKLNGATGTyaAVPGTDWPAVSKAFVEGLGLTWNPLTTQIE---SHDWQSELYADIARFNRILHNLATDVWTYIS--LGFFKQIPVP-GATGSSTMPHKVNPIRFENAEANLEISCALLDTLSATLVTSRMQRDLTDSTTQRNIGPAFGHSLLAIDNVRRG-LKALAVNGDLLADDLDANWEvaMRAASVAgyERLKELTRGHRIDGDDLRAFVAGLGLPDDLAArsAMTPGSYVGLAEQLVAEYL----
    348 UniRef50_C2PYS8        Argininosuccinate lyase n=2...   227     6e-58  1  14.1%  19:473   5:441     ------------------LTGRISATPARLLHEEVLEPQFRYEVEYLLPAYIQIEQVMLLEYVRMCWITAKEGQEISQILQSITSGGLVAD------------PVNNmdIAFGIERLV---------ESSLSVPVPCWHMDRSRNDFQACAQLIFGRAQWLELMQNLIELIESMDILANQYREVGMPGYTHYQSAQIITPGFYLSTINQELLQTLKRWIRVYDDMNQCPLGSGAMAG------VELDWDRDRLASLLGFHQVRL-TALAAVASREWVLQASSELSIFSVLISRFTTDLMQWGSSEMNFINLP--DELSGISSAMPQKKNFPILERIRGKSAHLSSFYLDMVLGQRNTPFTNLVETSKEAGTHLLTMFRTTKSLLRLLKTVIDHLSFNEEQmkRDFFGGFTLANLLttGIPYRKAQVIVGRYiaSQRSLMPMEGDERLLQeeEGYEVSDLSDILTTAFDIRKNL-----
    349 UniRef50_A8MCU5        Argininosuccinate lyase n=1...   227     6e-58  1  16.5%  37:448  18:407     ------------------------------------YTSSLLDDAEIYRETILALITHVNELNKVGVLPSNEAEAIIKALRSLAKEPYKP-------------SDEYEDVHEYIEAVLIHRLG---------DAGGWIGLGRSRNDHVATALRLRLRKLIIELASSIIELRRVVLNKAIETADTVIIGTTHRQPAQVTTLGHYM-LYLDELSRdlTSLLSIYEVVNKSPLGSGPLAGTM------VKLNRVREAEELAFNGI-VENTVYATGSRYFMLASASITVSYLVELGRFINNIEMWLMPQLNYITLE--PSHLATSSIMPHKRNPATLEVFRARIGEAVGHLVSMYSIERPVEAGYQLDLQEETRHAWLIMRIAIDGV-GMITDLLRGIKVNEGRVKEDLVKYPVTAAEYvpFRNAHrvAVMIKEGKNPGINPTEAIRGKEVL------------------------------
    350 UniRef50_A7GZH7        Ribose-phosphate pyrophosph...   227     8e-58  1  40.3% 198:465   1:268     -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTFGQYFSGYVSFVKRMEAKFKALLDEASELPLGATAIGTSLSVHEGYLSKVYEKLNLVTGKKFKMEENLFDGLQNADFYIEISANLKRLATTLSKIATDFRILSSGPRAGINELNLPAVQPGSSIMPGKVNPVIPELINQIGYQICGNDVAITMAVEGGELDLNVWEPVIIKNLCESFKLLQNGLIIFANKCIDGLEPNEQICAKFANDSTALSTIISSIFGYKVGTKVARKAFEEDKSVKEVVLELKILKPDEADEVLDTFVMIYP-------------
    351 UniRef50_A6DT96        Argininosuccinate lyase n=1...   227     9e-58  1  14.0%  41:476  26:426     ----------------------------------------LDYDNKLLPWDIIALISHGRMLAKCELISASDAELIETHLQEMKQEALDGTLKMLPEI---------EDCHSLIEDELIKRAG---------DAGKQLYMARSRNDQVVSATRLFGKDKLIKIKHTLKSFIEELLNLASKYETTPMPGYTHTQRAMPSSIGLWASSFAEILINQKETIDAAISLNDVNVLGSAAGYGT------DFPIDREFVTKDLGLARTQVNSLSCQLSRGQVECQTLQSLWGTMFVINRLANDMVWMTSAEFDFLD--VGKSCTTGSSIMPNKKNLDPCEIIRSRYHLFTGQISQAQGVISNLFSGYNSDYQETK-GVFMEGLTLVEESLEAMGIVISNTDIKEERLLSFFSK-DIYATDL------------VNRQVIEGKTFRDAYIekKSLDTVELE---DPYENVkpGNPGVDILKER--
    352 UniRef50_Q7W582        Putative argininosuccinate ...   226     1e-57  1  16.3%  44:478  33:465     -------------------------------------------HEDLFHAMSRVNLAHAVMLRDRNLIPPEAARALVALMAELFERGPSSVAL------------------EAGAGDLYPQIEAHAAALLGADVAGYLQLGRSRGDVIPSAMRLKLRIKLMRLLASVLALREAILDRAVERADTIMPAYTHWQQSQIMTVGHFLGRFSAWLERDTQRLFECVSRHNLSVLGSagVGTS-------VRVDRAMTAAWLGHDEPTLSTG-DGTNAWDYMIEPVSVAALLCSHLARLTGNFILWHTQEFGMVR--LSDAFCTASTYLPHKRNPEPLETVKVFAEQVQGALATVYLMA------RNEDWPHSLInaINGALTLSGDAADLTGAIMRDISFDPARMRELLDLSYATASEVapFREAHevGTAVRACMADGRavRDAArdLPPIDDAQLAACIDPGNFvgTAPAEVRRVLAVWR
    353 UniRef50_B2AVP6        Predicted CDS Pa_7_2220 n=1...   226     2e-57  1  15.4%  17:471   9:495     ----------------TPLSTRYASQEM----------MTIFSARERASTWRQLWVWLAEAERELGliPEDAIQEMRENVRVSDEAFDKARefRHDVMarGKGDDVNGGRYRMRQRLLDISIWGLRVVMVSFdgWGWMWLG--RWNMTDNADLIFQKKALDLILPKLAKVIQNLQVFALKYKDLPTLGFTHYQPAQLITVGKRAAQWIQELMMDLEDIETVRDRLQFRGAQGTTgaTFLELFEGNADKIveILCKKAGFP--SAYPISTQTYTRKVDLRVANAVCALGATAQRICSDIRHLANLKEM---EEPFEKSQIGSSAMAYKRNPMRSERITALGRKLARLPADFTATFETQWFERTLDDSAIRRMDIPEMFLLADSILLALDNVTNGIVLYPSVIRSRIdaTESILMKLAThvSRQEAHEEVrdVVKQQgdLLERIKKTEFFRPvdIDSLVDPKLFIGNCPKIVE-------
    354 UniRef50_C7Z8U2        Putative uncharacterized pr...   224     4e-57  1  14.1%  41:472  46:480     ----------------------------------------LFSQRSRHSTWRKLWLGLAESEKELGiiSAEALEEMRAHLIVTDSDFEVA------------------RVEEKI--RRHDVMAHVHAfaVAPSAAGIIHYGATSCYVTDNAELILMREAMDLLLKKLAKVISNLSAFALKWKEEPTLAYTHLQAAQLITVGKRAAQWVQDLMFDLESMEQVRKDLKFRGAQVGTTGTQASFLehGDSAKCDKLNDLLcfDFPACYDVSTQTYTRKVDLVVANAVAGLGATAQKICGDIRHLAHWKEI---EEPFEKSQIGSSAMAYKRNPMRSERVYSLARELMSKPTNFANTLSDQWAERTLDDSAIRRIDIPEMFLLAEAILIGLDNISDGLVVYPKRINARVQetETIIMRLvqGASRQEAHEEIrlSHEAGYEVKNEGKPNDLVArgELDNMLKAELYTGRSAEIVDK------
    355 UniRef50_D1A3W6        3-carboxy-cis,cis-muconate ...   223     1e-56  1  16.8%  44:437  21:380     -------------------------------------------DEAWLRALLDAEIALARAQARLGLIPA------DAPAAVARAAGRITDAGRLAVQARRSGNPVVPIAAELRA------------------ATPHAHHGATSQDIADTAAMLVASRTRALILRDLDRTCAALAGLAERHRDTPMAGRTLGRPALPVTFGLKAAGWLLGCLQARRRLAQVR---LPVQLGGAA-GTMSGYGERAVELLP-LYAAETGLD----EPVLPWHTVRTPVVELGAALAQTAGALGKFATDVMLLSQEEVGEVAEPAAP-GRGGSSAMPHKRNPVLSTLIRSAALQVPAQVAVLLTAQGGAAHERPAGEWHAEWQPLRECLRLTGGAAETAAELAAGLQVFPDRMRQALDRLVQTLRAHGSGTGLGSAQALVDRALAHYRT-----------------------------------------
    356 UniRef50_Q161F2        3-carboxy-cis,cis-muconate ...   222     2e-56  1  14.6%  33:476  14:437     --------------------------------LFPVGEtrLFSDSAAIRAMLLVEGALAKAQGKLGIIPETSAAAIHRATLEIQIDP---GALATSTGQNGVCVPGLVDA--------------FRAEMNAPEHAQFVHWGATSQDIIDTALMLRLRQALALAESDLSELLSRLAAAAEEHATTPMAARTYGQVATPTTWGAVVAQWGMPLADALDALPHLRQSSLFVSL-SGASGTSAALGAQAPD-LRRALAAGLGLQDPERS----WHTDRTPLLRISDWLGHVATILGSMGSSLNGLAASGIDEVAF----DRRGASSTMPQKQNPIAATGLVALSNQSCA-LRAGMTSAAQHRHQRDGTAWFSEWMLLPQIVLTTASALQIATGLAGEVQPNVAQMQAGLETGNGlaEALspRPQAQAakALCAQAVAEGASLPDLARAAYPHLPQTLFQA---GHQLGQAPEEARAFAAR--
    357 UniRef50_D1NU88        Adenylosuccinate lyase n=1 ...   222     3e-56  1  14.4%  17:474  13:480     ----------------TPLDGRYRKQTAPLVEYL--------SEPALNRERMRVEVEWMILLAnqGVKptDEEQAYLRAIPETFDDEGIERHAAHEAI-------THHDVKAVEYYIDDElaEVLGHPTQLTELKTLVHFACTSEDINNLSYARCVKNAMEQvlPSAKAITAHLMGKAEEFAELPMLSLTHGQPATPTTLGKELAVYVYRINRQIRHIESQE----YLGKINGATGTFGAHLAAYPDVDweFVTNRMGLTWNPLTTQIE---SHDWQAELYGTVSHANRIMHNLCVDVWMYISR---GVFAQVPVKGATGSSTMPHKVNPIRFENAEANFELSCALLDTLSATLVESRWQRDLTDSTTQRNIGSALGYSLLALDNLLGG-LQSIHPDQATMQAELDANWEvaCELAGlrPYEKVKELMRGHRINQDDVQRFI-DSLQFDEQTAARllTPASYVGVAADLISFAE----
    358 UniRef50_Q7KWJ4        Adenylosuccinate lyase n=63...   221     5e-56  1  13.1%  18:474  13:461     -----------------PIDGRYKRSCQEVSEYF--------SEYALIKYRIIVEIKWLLFLNDKEYFFPKVSEKSLSNITSIMELINDNDILRVKKIEEE----TNHDVKAVEYFIREKL--ESLKNEEITKVIPYVHYLCTSEDINNIAYGLCLYNCIHNIIIPNIQNidKLKEFSFNYSDVSLLSKTHGQPASPTTFGKEMSNYYYRLYKHINKLKNIEIYVKFN----GAVGNFNAHKVCDPNIDwyFIETYFNLHFSLYCTQI---QDHDYICEISDTLARLNYTLIDLSVDMWLYISSNVLKLKVI---QKEIGSSTMPHKVNPIDFENAEGNLHLANSLFKLFSSKLPISRLQRDLSDSTVLRNLGSSFAYSLISYKSLLRG-LNKIDVDQNVMNEQLNQNwtLAEPIQIImsYEQLKNFTRGKSIDKQCMYQFIQQnsHLPKNAIDEllTPHNYLGYASYLSKNVE----
    359 UniRef50_UPI000050F815 3-carboxy-cis,cis-muconate ...   221     6e-56  1  14.8%  43:475  24:448     ------------------------------------------DDVALVSALGDVETAWINAQAHAGLISADARAEAVEAIAA-TTRSLLADSAELETLAADAESGGNPVIPFLKAVR----------SPLGEDASRALHKGLTSQDVMDSALGLLMARVARQTHARLDVIAELLVGLSEAHADTVCLARTLTQPALPTTFGLKIASWAAEVHE----VQSLTPRIDYVQVGGAA-GTRAaaGTQTETLLREFHVQLRGPDAALTSIPVPWHTDRVRVLNWASHLTQCVTVGASIARDVLIGTRPEVGELAL----AATGGSSAMPQKLNPTSAVLLHRNGMRAPGLMATLTSTAAEAIEERSDGAWHAEWPALSELMGLAVSSLIMLQTMVEGLSVNPEAMRKNVDAagIFAERLNIAFGDRLSKAEVQEIINPGgaLTAALEKHPTEDEETLDLafSPENYLGDAEDIRQSIIA---
    360 UniRef50_A0P1F3        3-carboxy-cis,cis-muconate ...   221     7e-56  1  16.2%  40:478  22:435     ---------------------------------------RLLDDGSDVAHMIAFERALATVQGRLEIIPAQAAREISEKLAGVHIEPARLEAGTRS------------------AGVPVPALVAELRKQLSADAGAWLHWGATSQDVIDTAMVLQAKVALEILGARLEKLIDTLERQSARHADQLMAGRTRSQVATPITLGYRIAQWAHPLIDAENALPALRSAVLRVQFG-GASGINSAIAPDGT-TVSTALALELGLEDSP-----SWHVNRTPILALAGWLQQLTSALAKMAGDLALSGRTDIAELA----SGTGGGSSTMPQKANPVQAETI-QVLNSIAIAAQAGLAAAASPLEERDGTAWPLEWHFLPQMLLAAGAALVHAEDLATSLQAHEANLAATLAANPEIMAETASfvSRAEAKDLVAAAAKDPAPFAEALARLAPVS-LDWQKELDPHQVVAPAKDMSDRIFQARR
    361 UniRef50_Q1D262        Argininosuccinate lyase n=2...   220     7e-56  1  17.0%  10:461   3:402     ---------DTLWGKGLPLDA--------AIHRFTVGNDPV-VDLALAPHDALGSAAHARMLARVGLLKDAEAKSLVTALKALHDEARAGTFVIR---------PEQEDGHTALEAALVERVG---------EPGKRIHLGRSRNDQVQLALRLLLREEVLTLGARAAELAGAFLDFAQAHKDVALPGYTHLRRAMPSTFGLWGMAFAEGLLEELEALRGVWARLDRCPLGAAA------GFGVPLPIDREYVAALLGFSRVQRSPIDVQNGRGRHESAVLGWACSVAGTLEKWLWDVQLYSMDEFGFLGLP--DAYTTGSSIMPQKKNPDVVELARGRCRELRGLAHQVEAVAGGLPSSYHRDFQLLKSPTLTALG-STRELLDVLTRLVPALQVKADAAARASDDTL---------YAAHHAYALV----AQGQAFRDAYKQ---VGRELVEGTFRPDR-----------------
    362 UniRef50_A1RR78        Argininosuccinate lyase n=5...   220     8e-56  1  18.6%  32:456  13:416     -------------------------------ELIKRYTSSIKDDVEIAEEVIKVMEAHVKHLAEVGIMPKEAADAILKTLKEATPEQLLSSEF--------------EDIHEALEKWLIDRLGE--------ETAGWVGLGRSRNDHVAAAIRLAALRKASALRKNVEKMRCILAKKALEYADCAMPSFTHFQPAQAITFGHYLLAVDELAAEFLHVLKAVEKLLKRSPLGAGPAGGT------RTPIDRERLAKLAGFEDV-VENALYASGSRFFALALASAVVSFLTELSRTVDDLIRWNSPLVGYVAAP--DSHVSTSSIMPHKRNLVTLEVFRARAAEALGHLTALNAVVMKIGLGYSLDLQEATRHLWAVLNMATEGV-EIFIDFLEKMSFNCVKAREDAEraETIALSGVPFraYFQLAKEIKEGTARLMSIEEALQrrGSANPEEVKKA----------------------
    363 UniRef50_A3KFG3        DabB n=2 Tax=Actinomycetale...   220     1e-55  1  16.1%  54:445  38:411     -----------------------------------------------------VDLAHVIMLAEQKLLPADVAGRLLERITELRGTGFAAMVDVPAP------------------RGLYLAYENLLTAELGTEVGGKLHTGRSRNDIKATTTALRLREQVTALAAELLRLQAILLNRARVHAGTVMPIYTHFQPAMPVTYGYYLTGLALAVGRDVLGLRQVLAGLDRSPLGAGAVAGT------DLPIEPARTAELLGFAGPPV-HATDAVASRDGVLRALAAAATAGVTLSRLGTDLQLWSTQEFGFLVFP--DRLVGGSSAMPQKRNAFLLEHVKAAAGGAIGAWTAAASTMKSAPFTNSIEVGTEAVGGSGAALAALSDAVQLAQVLVSGAQPDAARMLQRTGEGFVTATVivPFRAAHhvGAAVRAAVDAGETELPAIAEL---------------------------------
    364 UniRef50_C7R360        Adenylosuccinate lyase n=9 ...   220     1e-55  1  12.5%  19:475  21:483     ------------------LDGRYRGAIAPLVDHL--------SEAALNRERLHVEVEWLITLTntGPiaPTLTDAEKDYLRAIVTSFDADGITELASIERETVHDVKA-VEYYIKRRIADAPTHLGANTSLPAVSELVHFACTSEDINNLSYALMVKGAVTQvlPAARALADQVAAMAHEHKSVPMLSRTHGQPATPTTLGKELAVLAHRLRRQITRIEHDE----YLGKLNGATGTFGAHSVALPDVEWPQVseHLGLTWNPLTTQIE---SHDWQAELYSDVARYNRILHNLATDVWTYIS--LGFFTQIPVP-GATGSSTMPHKVNPIRFENAEANLEISCALLDVLASTLVTSRMQRDLTDSSSQRNIGSAFGHSLLAIDNVARG-LDRLAVAESVLRGDLDANWEvaVAGVDGMdyERLKELTRGQRIGSADLIAFVRGLGLPPQdeRLAALTPATYVGLAQELVETYLE---
    365 UniRef50_C1XGT7        Argininosuccinate lyase n=2...   219     2e-55  1  16.8%  42:469  18:432     -----------------------------------------FAKEHLGDHFFDALTAYALGLGKLGIV---EAKEAAWALSQLRKDPIPG------------FSGQLEDVFFTIDFYLRERFG--------SEVASALRRGLSRNDLDLTVFRAYACERLLRVLTSLSDLRRELLGLGQNHRQTLLTAYTHHRPAQPTTLGHYLTGVENLLSRDYQRLRSAFQTTDKCPLGASTLAGS------PYPVDRKALAQWLGFGG-TLEHTYDAIAAGDWALEIAYALAGMATSLSRLVADLLFWAEQG----GFLVAEKISQGSSIMPQKVNPVVLEHVRGFLAELMGGPTTLGHLNYSTPFGDVNDHGPGVLEPLYNLFYAAEGAVALLRVALQESRFVPEVLAQGLRDRSVLASELVDVlaYPKVQGMLRELSSKGRTVAELGLDDLqfGDPELLQALEPERFigAAPEA---------
    366 UniRef50_A8M9J3        Adenylosuccinate lyase doma...   219     3e-55  1  14.2%  18:475   6:444     -----------------PLDARY--------RNELKGYHEVASEDAFIMYRAKVELLYLEFlsKLGLV-----KPINDEEKRRLRGIRLSSGDVNEVRRLEDELGHDVKALEYVLRGRLKAIG-------LEDYAHLIHLGLTSEDVNNLAMGIMIKRIleYLIPSLVDLGKVLVNLSNKYADTPMLARTHGQPATPTTFGKEIAYHSHRLCSWISTLINLKINGKVAGASGSMASFTMIAQLDWPRELMNFVSS-LGLEPTPVATQILPP---DNLNHIIAAVGLTSYSLINLAQDMWMYSM-----LGYIKFKGRVIGSSTMPHKVNPVDLENAEGNLKLGASMLMEISKILQSSRLQRDLSDSTIKRNLGLAMGYVVLGSRRLRKFM-EGIEVNEEALTNDLNNHWEVLSEAVQVraYEKSLKLFRVPRMSMSDYINAIKELGVNDELLLN--LRPSNYIGYASVIARNIAE---
    367 UniRef50_C1D231        Putative argininosuccinate ...   218     4e-55  1  16.2%  46:478  21:440     ---------------------------------------------HLLPHLFDALTAHALMLSQCEV---EHAAEAAGHLRNLRKKPFPP------------YDPRIEDVFFTLDAALTDR---------DPAAAGALRTALSRNDLDMTIYRLSARMRLMRAISRILTLRQTILTLAEREVETIIVAYTHHQPAQPTTFAHYLTAVENNLARDTERMFGALGRLNLSPMGAVALGGTS------FPINRTMTAELLAFD-RPIENTYDAVSASDWQVELASIITITSTTLSRVLYDLLFWASRGLI----VLPDGLVQGSSVMPQKRNPVALEHARTKFSKAIGMTQSIILSSHNVPFGDINDPGPDMQPSLHSMWQEFREGVELMTVSLASPRLNRDLWLLEAQHGESAVTELADAMTRhrIKRLLSDLHAEERPLYTVTINDldLSEAELRSALDPAAFigPAPQVMRGELRQAQ
    368 UniRef50_A6G4E8        Adenylosuccinate lyase n=2 ...   217     7e-55  1  15.4%  14:475   6:457     -------------KYESPLSSRYA--TKAMLANF--------SDRRRALLWRDLWIALARAESALGL---------------------PVSQAQIEALVAARETIDFERVAEIEASLRHDVMAHvfGDVAGPEAAKIIHLGATSCFVTDNAELVMIREGLELLMDRLYTCLTQLRSFAQTWRAEPIQAYTHFQPAQLTTVGKRACLWAQDLAFDLETLEQLVARLPMRGVKGTT-GTQASfpNAAIRELDRRVCEAMGFDRSIAVSG--QTYTRKIDTWVVSALADVAGSAAKFASDMRLLAHEREL---EEPFGKKQIGSSAMAYKRNPMRSERINALARFVHSLATSPRETHGNQWLERTLDDSANRRLVITEAFLATDAILNLVVDVTAGIVVNPAMLAKNMADELPFMATENVLmdRQALHETIRqkAGRGNDLMARMQEDPELGPHVDAGALDASRYVGRSPAQVDDYLA---
    369 UniRef50_C0WN00        3-carboxy-cis,cis-muconate ...   217     8e-55  1  10.6%  39:461  21:432     --------------------------------------RAVWSDENRLKIVCKVETAVAYAMSKNKKMPLSAYEEIKEKIVPENYDMTKLRLSAARAGHFLAGFVSY------------------SQQLFEDGGGQYLHYGAASEDVEDTCYVLQLKQADKIIMDYLVKFGSVLYDLADKYKKTINVAMAHRTYSSPSTLGFKLGIILNELDYLMRRLDSLSDFTFAGSLTG--VEGLSTMVGDNYDQVETDFCDYLDLQ----VPEMYWHTQRERFTEYCHVLTMIAQMLGKLGKDLLTMSQTQVGEFQEAYAPGRQ-GSTVIPTVREPYMCEAIV-NLSTIIRNEMPLMYDTMQVSGEKDTAVWRDIYVVLPEMTMYLSGQLNYATTILKTGKFDTKRMAENfmYSGALMMALAKkmGRQDAHelVrkADEENKLLKDLFYSdkYLSRQDLDKVMSPEA-----------------
    370 UniRef50_B1LWD9        Fumarate lyase n=2 Tax=Bact...   216     1e-54  1  17.6%  53:478  31:461     ----------------------------------------------------QINRASLVMTVETGIVPRALGATIARALDRVAADAAKPGAERPDDY----------------------LRIEPLITAIAGADATRMHSGRSRQDIIPTVLKLEQRDRLLNLAKALDETRAALLTVAEREADTIVPAYTNGVQAQPTTLGHIYLGYAAVLARDADRLRETWARLNLSPLGAAALGTSS------FPVNRERLAALLGFD-APVENSYdqLAPMDMGIELTGLAANLATTAGSFAQDLYAQYHQTRPWI-LLREGALTGPSSIMPQKRNPVALYSLRMKASDVVGAAQAFVIMAHNVDSGMPDYKRNQAEPPGRTLAEAAE-MCRRWTHVLDGLVVDRARAADEVAADYSTTTElvPFrgHHFASELVSYGRSHDLRPADllTPDLPLDEARFRAALSARGMigPQPAEVRRMLGAAQ
    371 UniRef50_D0WKE9        Adenylosuccinate lyase n=1 ...   214     6e-54  1  14.3%  18:470   6:461     -----------------PLDGRY-RETVAPLTAFL-------SEAALNRARIAVEVEWLIFLSQNEVFPGAPVVSEADVAYLRAIPQKFGEAEIAEHAAIEAETKHDVKAVEYLIKRRMEAAPDVVgnTALPSLTEMVHALCTSEDVNNLAYALCIKGAVTDvfPAALKLHDALAELAHAHADLPMLSRTHGQTATPTTVGKEMAVFAHRLSRQLRRIASA----DYLGKINGATGTFGAHVAALPDVDWPALseGLGLVWNPLTTQIEPH---DWQADLFSDVVHANRIAHNLATDMWTYIS--LDYFHQNLAAQGTTGSSTMPHKVNPIRFENAEANLEVSSALFETLAETLVTSRLQRDLTDSTTQRNIGVAFGHSLLALDNLVRG-LAGVDPNPQRLAEDLDASWEVLGegATGMgyERLKELTRGRKVTAEDMREAIASLGMPDDVAAraALTPAGYTGLAARLV--------
    372 UniRef50_B9P6D5        Predicted protein n=1 Tax=P...   214     7e-54  1  15.9%  42:444 259:646     -----------------------------------------FADARWLDALLRFESALAQAQADCGLVPRPAAEAIARACAQAPLTCEGVVEQARASGALG---------------LAVVRPLQQWLQAHAPEGLPWLHWGATTQDAVDTAQALLTQQALQALLAELGALQCALQALARTHAATPMLARSLLQPAQITSFGFKCAQSAAAVGRSIEQFERLATAALCVQLG-GAVGNGAVLGSHRAE-VEQALARRMGLSACGRS----WHTQRDDWMRLAMEAAVCGGSLAKLAKDWSLMSQYEVGEVSEAP---RGSTSSAMPHKRNPVHLMQAVAQAQAVPP-LAALLLGCMAQAHERALGEWQSEVAHWPDLWRHVHGAAAALRQAAQSLQVHPQRMLGHVRGLHGLVfaMAPWTGKPEALAAVeqALEQGRELRLLLAE----------------------------------
    373 UniRef50_A0K2D1        3-carboxy-cis,cis-muconate ...   214     8e-54  1  13.9%  37:476  22:467     ------------------------------------SVAVLTGDRAVLAAILAVEAGWASVLEKAGLAPAG------------SAAVVDAAADVDRYDVAGIAVRAQGGANPVIPLLADLRAEVKALDTESVGALRAVHASLTSQDVLDSALMLLARNAVTALMTDVRAITTALAVFAEQHADTLCVGRSLTQHSLPFTFGLKAAQWFHGLAAAARRLEAvqTGGAAGTLAAGTVLTKGSVDTPFD--LSGNLAAHLGLAVAPGP----WHTNRLAVTSLGDALAAVTDALGKIAGDVLFLSRPEVGELAEPRAAGRGV-SSAMPQKQNPVLSVLVRSAALQAPGQAAQLHLAAANFNDERPDGAWHSEWPAFRQLLRLALGAAGHLRELAEGLQVFPAAMRRNLELSGPLLlaVAPLlgKQQLQDVVDRTleQSGTYRRLLReaSALSDEQLEELLDPASYLGQAGEISRRILAA--
    374 UniRef50_Q3JSA0        Argininosuccinate lyase dom...   213     1e-53  1  16.0%  46:463 463:842     ---------------------------------------------AELDAFAAIDEAHLLMLVDAGICDRARAATVLAELARQRDAKFAAIADAIAPRGTYA------------------LYEQLLIERVGIDAGGAVHTARSRNDINACVAKLRAREWFDTCGGKLWRVRAAIVDKAQHTLDWPLPTYSQYQAAQPGSFGYYLWSVETALRRDQAALERLDEELAVCPLGAGAGAGT------DFPIRPGVSAALLGFA-RSFDSALDAVASRDLVLHFLAAIAIASTTLSRLAHDLQLWTMRETDFLALP--DELSGGSSLMPQKKNPYLLEIVKGKLAHVAGALNAAVFASQRTPFSNSVEIGTEMLAPCADAVQAFGESCDLLRLMVSGVTGDPAKMRAAAEAGLVSAT--------QVANALVR---ETDISFHAAHRQIGALITQALDAHEDPAAAL---------------
    375 UniRef50_C9Z894        Putative 3-carboxy-cis,cis-...   213     1e-53  1  16.1%  44:477  26:484     -------------------------------------------DTAYLRALLDAEAALTRAQAALGLVPAAAGPAVTSAADAAAFDARSLAE--------RARGGGNPVIP----------LVADLTEAVGDPYGPYVHRGATSQDIMDTATMLVAARTLDLILADLGRTESALAALAAAHRDTVMPGRTLTQHAVPTTFGLKAAGWRSLVLDARDRLAVVRASLPA-QLGGAasGTENAAAGTGAeaLVAAYAREVGLR----EPELPWHTLRTPVADLAGALAFAAGALGKVAADVLVLARTEIAEVAE----GSGGGSSAMPHKANPVRSTLIAAAARRAP-QLAAALYGALAAEDERPAGAWHAEWEPLRDLLRLAGGAARDAVDLARGLRVDADVMRAHLDLTHglAAELAPVLGRARAKElaRRVHAEGRPLGELLSEEPELsgLDLADLVDPRRYTGSAATLTDRALERR-
    376 UniRef50_C6HSD2        Adenylosuccinate lyase n=1 ...   211     5e-53  1  13.9%   8:473   3:428     -------ENDTY---QTPLASRYASNEMK----------TIFSARTRSTTWRKLWIWLAEAEKELGviSDEAIAQMKANVLMTDNCFKVAA--------------------EEEKRRRHDVMAHVYAFGQVAPAagIIHLGATSCYCTDNSDLISIRDALDLVRPKLATVIHKLSQFAVEYKDMPTLGYTHYQPAQLITVGRRAAQWVQDLLMDLEDIERARNDLRFRGAQGTT-GTQASfdRAKVDKLNEIICTKAGFPSCY--PISTQTYSRKVDLRVANAISALGTTVQRITGDIRHLAAQKEM---EEPLRKIKLG--RLPWRINGILC---------------------AANWFERTLDDSAIRRITIPEMFLSADAILIAMDNVVSGLVVYPARIRKlfMATENIMMKMVS-LGkhQASDVVKNQGGKN-DLIERMKKSKFLAPvdLDQLLDPMNFIGRCPEQVEKF-----
    377 UniRef50_UPI0001692E4A aspartate ammonia-lyase n=1...   210     9e-53  1  40.7% 222:457   1:236     -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MDDLLEIGIGGNAVGTGIHTHPKYAELMTEEIARRTGRPFRSTANRFAFMQNPSAALRVSGLLREIAVHLIKMTSDLRLLNSGLHTGLAEINLPAVQPGSSIMPGKVNPVLPEMTYMVCSQVIGNDTAIQTAMIGGQLEINVMMPVIAHNVLFSISILSRTMKSLSTKCLKGIEANREQSRWWMEQSLSLVTLLNPVIGYDHASRLAKQSLQERKPLKEVVLASGVINEVEWNQLV---------------------
    378 UniRef50_Q3MNP2        Beta-carboxy-cis,cis-mucona...   210     1e-52  1  13.8%  44:420  20:370     -------------------------------------------DAALVGAMLQVEVAWLRALARVGAVDSDLAGQVAKVTQDWEVDMAALAAESEAAGN------------------AVVPLVRLFQEAVGQDAARVVHRGLTSQDVVDTALVLLARDALVRMGDDLAATSRALAALAGRHRSTLMVGRTLTQHAVPITFGLKAAQWLAGVLDAVAQVDDILGTLPV--QCGGAAGTLALVGELTDeaAARAFADELALDW----PGVPWHTNRSVITRIGSAVVSTCDALGVVAADVSTLSRPEIGELREGTV-AGRGGSSTMPHKRNPVLSVLIRSVALQAPLLGAQLHLAAAQAVDERPDGAWHSEWPALVRLLEAGVTSASQAAELTAGLEVDGKRMGDRVAAA---ADELLSERG----------------------------------------------------------
    379 UniRef50_Q73MK9        Adenylosuccinate lyase, put...   209     1e-52  1  14.1%  18:478  12:477     -----------------PIDHRYSLPQGGLYDELSvsEEAGIVYCAMAE-MAIVKAHLKIAEEKKGSLLPKLSGELEKTLDDIALNI-----DPSEVYEEEHKTQHN-----------IRALVNVLKKKVPENTAPLVHLGATSADILDTAFSMRIRDaiKVIIPLLKKTELLLCDIAEREAETPQVGRTHGQHAVPITFGYAVSEYVARLGKSILKMEDLVKDLR--GKFAGAVGAYNAAsvSDPMRFEKIYLDYLGLKPSEYSHQLV---EPEYMLRLLLEANIAFGIIANLADDLRNLQRTEIGEVFE-YFSATQVGSSTMPQKRNPWNSEHVKSLWKAFSPRIMSFYMD-QISEHQRDLSNSASQRFI---ADYLTGLALAfmNSILKGLQADRENMLKNLLQGGgiLLAECGVSDAHEvrKITLAAENQKISFYEALKAEEKVFaeRLKElfdpERYRGLANVKAKALAEKYK
    380 UniRef50_B0U8T5        Fumarate lyase n=5 Tax=Prot...   209     1e-52  1  16.2%  39:471  21:436     --------------------------------------RTVFADEARVAAMLRAEAALARAEAALGLVPDALAPALEA------IPPASLDPVALGRGTALSGVPVIPFVKAVQAALPAPLEAG-------------FHKGTTTQDIADTALVLQLRDALDLVRDDLLAILAGLSDLARRHRETPCVGRTYGQQAAPVTFGAKAAIWALGVAELAGDLPRLRGKVLTASLG-GPVGTLAGLKEQ-ADAVGEGFAGELALRYDPAP----WHTRRARIAQTGTWLTLVMGALAKFATDVAFLASTEVGEVAEPHVP-GRGGSSAMPHKRNPVSSTVILA-AFSAAKGQVLPLLDGMAAAQERPAGAWHAEWHALPCLFGLASGALREARALAEGLVPDPGRMRANLDLTRGLLFADAAAagHRLVEEAAGAVRDGRGTLAEVLAARPETAGIDLGPAFDLAPAIRAGARTAD-------
    381 UniRef50_B2GIK4        3-carboxy-cis,cis-muconate ...   207     8e-52  1  16.7%  39:476  14:483     --------------------------------------QELLDDRAVVCAILAVEDAWVAAQHREGLVSAEEAAAAHAAVDRVGTDPHHLRELVTASEGGG-----NPVIPVLGAYRRAV-------EQVLGRPLPAVHASLTSQDVMDTALAHLLSSVRRRVVGDLTRAGDALAELVRRHRGTPMVARTLTQHALPTTFGLKAAGWLAAVDDAAD---EVSARVRLPLSCGGAAGTLAAtpLDPTQRLLHHWAGQLGLEVPDAP----WHTTRTPVVRAAGALAEVAAALSRLANDVLLLSRPEIGELREPTAP-GRGASSAMPQKQNPVLSVLLKRTALLAPGLASGVLAGAGAAVDERPDGGWHAEWPALGELAELTAAASSHAAELAEGLTVDAPRMARNLAdaEPLAVALAPmrGADTARQLVRDAVrtERLAEAVAASDGAVAPPGVDalTDPRAHLGAAPQLCDRAVAR--
    382 UniRef50_Q7CV75        3-carboxy-cis,cis-muconate ...   206     1e-51  1  13.8%  40:394  22:345     ---------------------------------------ELFSARADIDAMIRFETALAQAQVGTGIISEDVAKAIVSGLSEFAADMTALRHGV------------------AKDGVVVPELVRQMRAAVAGKAAEKVHFGATSQDVIDTSLMLRLKMATEIIAARLGRLIDALGDIAARDGHNALTGYTRMQAAIGITVADRAASWIAPLERHLLRLETFAQSGFALQFGGAA--GTLEKLGDNAGAVRADLAMRLGLA-----DKQQWQSQRDGIAEFGNILSLVTGTLGKFGQDIALMA-----EIGTEIRLSGGGGSSAMPHKQNPVNAETLAALA-RFNAVQISALHQSLVHEQERSGAGWMLEWLSLPQMVTATGASLLIAERLAAQI------------------------------------------------------------------------------------
    383 UniRef50_A9WJB9        Adenylosuccinate lyase n=3 ...   206     1e-51  1  14.4%  18:476  14:460     -----------------PLDGRYRADVA--------SLASFFSEAALFRYRVRVEVEYLIFLSRARGIhpPLTPPQQAALRALYRQFGDDDALAIAAWDRRV----NHDVKAVEY-----WLRERLTTLGLTGHLEAVHFALTSEDVNNLAYALMVKEARevLLPALESLLERIRQLADEEAATPMLARTHGQPATPTTFGKEMNVFFMRLRRAINDMMA----IKITGKLNGASGVFAAHHVALPQIDwrAFVRSLDLEPILLTTQIEPH---DTLAALCDALKRIGAILTDLSQDCWRYISD---GYLVQAARAGEVGSSTMPHKVNPIDFENAEGNLALAGALLELFSRKLPVSRLQRDLSDSTVLRNLGLAFGYCLLAYQRLLRG-LQKVAVDRARLRRDLDAHPelAEAIQTILRReePYELLK-SFSRGRALTAEDIadSLLVSDAVrqALAPAAYIGLAVKLAQLRDEA--
    384 UniRef50_C1DL35        L-aspartate-like protein n=...   205     2e-51  1  16.0%  42:478  57:496     -----------------------------------------PSEADQFAWINKINKASIVMLVEEGIVTPQMGRKIAGGIrtVDQAGRPGGKRPGDVLQ--------------IERIMIDDIG---------PEASLVHSGRSRQDILATYRLATLRRQVLDYAAAMNATRQRLLDIAARNADTLVPAYTNGVQAMPITYAHYLLAYAASFDRDAQRIRELYARLNRSPMGSAVLANSA------WPLNRERLARLLGFDEVR-ENSLdqVSSYDIPIEAVDIAANSAIRVGALIGDIHTQYHQIRPWL--LLDEGSTYTSSAMPQKRNPGLLMRVRESASDTVGLAEAVTLRAHNVTTGM-----TDYKFAFDSlfDAATDMFKGMDNVLDALTINAARAREELENEWTTSMElvPFrgHSFASLIVEEARNEGYVPNTFPYADapLDEAAFRASLSPENMvgPQPAEVQRMLAGAR
    385 UniRef50_UPI0001B4D944 3-carboxymuconate cycloisom...   205     2e-51  1  17.5%  78:477   4:439     -----------------------------------------------------------------------------RAAAETISRLARAELLDVRALALAARETANPVVGVVQALSRVV-------EREDPAAAEYVHRGSTSQDVLDTGAMLVAARTLRIIRADLGRAAEALAELAGTHRDTLMAGRTLAMHAVPTTFGVKAAGWRQLLLDADRRLELVLVALPVS-LGGSA-GTLAGYVerYVAELTEAFGAETGLAAGPA---MPWHALRTPIADLAAALAFTAGALGKLAVDVQSLTRTEVGEVAEPSVAGRGV-SSAMPQKRNPVLATLVRSAALQVP-VLAAGLTQCLVTEDERSAGPWHAEWQLLRECLRLTGGAAHTAVELAAGLEVRPERMRQNVAlsERLAAALAPRLGKAAAKRLLSMATesGRPLPEVLAHLPElaPKELDRLCDPAGYTGAAGALVDRALARQ-
    386 UniRef50_Q21774        Adenylosuccinate lyase n=3 ...   205     2e-51  1  13.7%  40:477  23:458     ---------------------------------------SILSETNKATLWRQLWIWLAEAEKELGL--------------------KQVTQDAIDEMKSNRDVFDWPFIRSEERKLKHDVMAHNHAFGKLCpaAGIIHLGATSCFVQDNADLIAYRDSIDHILKRFATVIDRLAAFSLKNKEVVTVGRTHYQTASLVTVGKRGVLWAQELLMAFQSLSEFRDKMRFRGIK-GATGTQDSfdESKVEALDELVTKKANFSNRFLITG--QTYSRQQDSQLVFSLSLLGAAAKKVCTDIRVLQA--FGELLE-PFEKDQIGSSAMPYKKNPMKSERCCALSRKLINAPQEALTILADQGLERTLDDSAGRRMLIPDVLLTAEALLTTLQNIFEGLSVQTDNVKkgLEKAMMMLTE--EGVDRQQAHAVIRKTALEAKQLQATQKVDIrmADPFFDSVRdpINFTGRCVSQTESFIAKE-
    387 UniRef50_A1B7S2        Fumarate lyase n=1 Tax=Para...   205     4e-51  1  14.5%  39:473  17:430     --------------------------------------AAILSDRSAILAMLRVEVALARAQADLGAIPAAAAEVIAKAAEALDPDPAELAAAVARAGITAQP---------VIAALK----------SAAGEAGAFAHYGATSQDIVDTALALQLVAALDLLGGRLDRLTALLVQKAADHADLPIPARTRHQIAAPTTLGAKIAVWHGMAARNRQRLDELRPRLLLVSLHGAA--GTEAALAGHGPALRASMAAALGLG----VPAGPWHAARDGIAELAGWLSLVTGALGKMGLDLVQLGQSEIAEVAAGAGGG----SSTMPQKQNPVAAEALATLARLNAGDLAGMHQALVHAQ-ERDGIALGLEWNLLPGMLERSAAALRIACDLAGTLVPRPDRIAaaADRGRMAAEalAQTLPRAEALRIVAQALAqgGEAPTLADALARLAprDWAEALRPENLTGAAPDQARAA-----
    388 UniRef50_C4LH41        Adenylosuccinate lyase n=31...   204     5e-51  1  15.5%  41:478  54:489     ----------------------------------------LWSPEHKIIMERRLWIAVLRAQKELGvvPDEAIEAYESVIDRIDLDSIAARERV--------------TRHDVKARI---------EEFNALAGYEHIHMGMTSRDLTENVEQLQVHRSLEHVRDRMVAVLRALADCAVRYRDQVMAGRSHNVAAQATTLGKRFASAANEILVAYERLENLISRYPLRGIK-GPMGTsvGGDETKLEQLENSVSEYLGISRRF--DSVGQVYPRSLDLDVISALVQLGAGPSSLSMTIRLMAGNE---LVTEGFKEGQVGSSAMPHKMNARSCERIGGLQIILRGYQTMAADLAGQQWNEGDVFCSVVRRVALPDAFFAFDGMVETLLTVLKEFGAFPAMIDKELErtRILMASIRAGLGRETAHEIIKeaVATALDMReaADDRLPLNREQLDAAidRHAFIGAAGSQVDRVVARVK
    389 UniRef50_C4DQU1        Adenylosuccinate lyase n=1 ...   203     1e-50  1  18.1% 119:478  49:449     ----------------------------------------------------------------------------------------------------------------------VVPLVNTLAEAVPLEVRGWVHYGATSQDIMDTAMMLVAHRATAVIVDNLAHAAEAAASLTERHRDTLLIGRTLGQHAAPTTFGAVAAGWLSGIDAARDQLRSARFELAA-QLG-GPVGTLEPYGTQGLRVLAD-FAHRLGL----ADPGLPWHTERTRVTRLASALATGAGTLAKVAHDVSVLGSSDVGELRE----GSGGGSSAMPHKHNPADSVLVLANVRRTPGLAAT-MFAALESELQRPAGAWQSEWQTLSQLLRCCGGASSRASSLLSGLRVDTGRMRSHLDATGGlaDQLAPALGRREAHELIADLAARAetFREFLDADphLTAAELDAACDPTACLPAARALVDRALARHR
    390 UniRef50_Q28RT3        3-carboxy-ciscis-muconate c...   203     1e-50  1  14.0%  39:467  21:423     --------------------------------------ARLLSDSAEVRAMMLVLGALAKVQGAAGVIPEISGAFLHRATMEIQIDPMGLAGANGVVVPG--------------------LVAAMRDALEAPEHAQYLHWGATSQDIQDTAQSLRLRQVLALMEGRLRDLLTVLTDLAEAHAETPQAARTYGQFAVPSSFGALVAGWGWPVIRLLERLPDLRDYALCVSL-SGAAGTASQLGPDPAALRAALAE-----ALGLSDPKQSWHADRARIIEIAGWLSGAAVAMGKIGEDVLRLSRSDVGEVRI----GGAGASSTMPQKQNPVAASALVALARMAPAQVAAMSVPHGEA---RDGAAWFTEWLTLPPLVSASARASALAIDLARNITADADAMAAHLqhAETLSFALTATLRraEVKRLTKEAIAHNRPLPDLVTedAPLPP------LTPPQSLGQAP-----------
    391 UniRef50_Q11F19        Argininosuccinate lyase n=2...   202     3e-50  1  14.5%  47:475  35:449     ----------------------------------------------KLEAVHAFDKAHLVMLVEQGLVGRQDGALMLSALRHMEKEGAVAT----RMRVGGALHSG----------------EYYLTERLGPKLGGTIHLGRSSADLAGVSRRIVLRTAVLSMARQLIDVQLTILNTAPDHLDCIIPAYTHGQPAQPTTYAHWLMMWANVFHRDTQRLLGGLDRLNLSPAGA-AVATGT-----DFAIDRSRVATLLGFDGILVNT-MDATLSNDVFAEYVSIFSLLCANMGRLAEDLLFWSTQEAGIA--VIPDRFCDTSSIMSQKRNPSFLHELRAMGAEAASTLLLVSGTEFGTTGQSVHARKTAENAVWALVGKIIKR-LPQMADLIASTEIDPQRAMRLTENSWsvASALVRHLghHVVSILVRLATERRLPPDQvaLAEAQIAAEDLDG-FDIADAVDVRAFVERRTNE---
    392 UniRef50_A3XE63        3-carboxy-cis,cis-muconate ...   200     7e-50  1  18.0%  35:395  17:345     ----------------------------------DQTIAAEFGVDAFLARMCRFEVAWTRALEAAGQITRFEADAAVEVIAQSSWRDYSAASD--------------------KDGLPVPGLVASLREGRETRVASAIHTGATSQDVIDTAMVLTCLNVLDELEDRLATLVDRLETLLDASRDLPLMARTRMQAAVPATVGLRVSSWLRPLVDHQSRIQALRQDLAKVQVG-GAVG-KRDTPADHAELVAEHVAHALGLSLGPV-----WHTDRTSLVGFGHWLTLVSGSLGKIGQDIALMTQQ---GVDEIVLDGG-GGSSAMPHKQNPVLAEAIVALSRFV-AHQQGLLAQSMIHEQERSGSALALEWMTLPAMAEATGASLRHTDGLIASIK-----------------------------------------------------------------------------------
    393 UniRef50_Q2P2F7        Argininosuccinate lyase n=2...   200     7e-50  1  16.6%  24:457  10:424     -----------------------GVAVDAKIQSFLAGDDVI-LDREFFLHDIAASKAHAQGLQHIGILSPQELDGLSEQLDLLAEDFRGGAF---------VLDEQYEDCHSAIEARLTERLG---------DAGRKIHTGRSRNDQILVATRLWLKDKLQRVATLSAEIAKVALDRAQAEAELPVPGYTHIQRAVVSSAGMWWAGWAEAFIDNAVRATDTLQLVDSNPLG-TAAGYGVNL-----PLDRAHTTAELGFARLQVSPIYAQLSRGKYELAALEALGSATLDLRRIAWDVSLFTSGEFAFVALP--AQYTTGSSIMPNKRNPDVIELMRATHASVAA-ARTEIEQLLSLPSGYHRDLQSSKGAIVHGFGRGLAALELLPALLANL-EWRPDKLRAAID-SGMYATdgVPFREAYKAAAEASDTAGQGRTPEGSLAArgAAADLQLDVLL---------------------
    394 UniRef50_A4JPB5        Argininosuccinate lyase n=2...   200     9e-50  1  16.0%  51:424 410:764     --------------------------------------------------LLAIEKAHLIMLREQGILSAEQFRSLREAVTTLEANPALLSEHVSGRGDYFDYEQYVID-------------------RCGRDTGGMIQAARSRNDINATHLLLTVRQALSHVTRRVVDLGETLARRAADSAEVLLPIYSQYQTAMPGSAGHYLVAQCEILLGTLDALASLRDGLGSSALGACAGAGTT------FVTDPRRTAVLLGFSTGPL-NSLSAITDKNPALRCACLLTELSSNLNRIATDLQLWSMREIAIVTLP--DGMYGGSSNMPQKRNPYLLEWLRLGHDRIAGYCATALSSLSHLPTGNSYQASRTAVETVSEMSGLVIDMLSVLVYSIDGIRFDANAARRAIDMGNAGAtrMASFRDAHAA------------------------------------------------------
    395 UniRef50_UPI0001AF7079 PcaB n=2 Tax=Mycobacterium ...   200     1e-49  1  13.3%  43:411  17:368     ------------------------------------------SDESLLRSMVAVESAWLGALADAGLAPIDRAGADLRHL---------VGEHDCELLAVTAEDGGNPVI----------GLVSLLRDRALPVVAPWIHRGLTSQDVLDTSLMLGMRSVADHVITQLAQQITTLSALAGAHRGTPMVARTLTQHAAPTTFGAKAAVWLNGVVDAYLRLGALVTPAQF----GGAVGTWSAtpAELAERVIRSATTTLGLRVR-----LPWHTTRTPVTAAADALVGCTDCWGRIAADVITMVRPEIAELGEPAGGPR-GGSSSMPHKRNPVLSILIRRAAVAAPHLAATLHTAAALANDERPDGSWHVEWDTLRTLARRTVVAGSQCGELLAGLDVHTSRMVQNLSAADVL-------------------------------------------------------------------
    396 UniRef50_C4JT38        Adenylosuccinate lyase n=1 ...   198     5e-49  1  14.5%   8:477   5:441     -------EFDVY---QSPLNTRYCSTEMK----------HLFSARKRFSTWRKLWTWLAEAEQELGiiSNEALEQLRAH------------QTITDQELADAAVEEKRRRHDVMAHV------HVYGQTCPA-AAPIIHLGATSCYVTDNADFI--------VSTQLTQISLTL---------------SLGQPAQLTTVGKRMCLFITDLLMDLENFEHAKKSLLSWFRGcgTTGTQASfqHELVERLDQLVTEKAGFHKAFTITS--QTYTRKVDTNIINYLGEFGATCERIGGDIRRLAAMKEM---EEPFEKDQIGSSAMAYKRNPMRSERLCSLGRHLQCLTQNGLTNYAAQWFERSLDDSANRRITLPEAFLTADACLILLDNISNGLVVYEKVIASRvmATENIIMALARhvSrhQAAAVVKNEGGQN-DLIERIKRTPFFApdELDGLLNPSSFTGRAPQQVEKFITEE-
    397 UniRef50_A7IQF5        Fumarate lyase n=3 Tax=Xant...   197     8e-49  1  13.6%  39:472  34:463     --------------------------------------EEVSGQGPLAPYLHLVEFAHVITLSERGVIPRAPARELVGALLDLHAGGSTGA----------------------VAELGDLYTNHEAQVAQRTKAVGWLGTARARREALTTAYHLLVRERLLALGTSLARLGRALAVTALTHADDVMPDYTYLQAAQPTSFGHYVLGFAAPVMRDLERLQSLYGRADLCPAGCGSMNGSVAFQ------DRAALAQRLGFSG-PLAHGRDAMWQADLAIEAMALSVAASVGLDRLAEDLMIFATAEFGLVR--LSDRHSRASKILPQKRNPYALAFVRGLANRLIGVAAGVAASGRTPTGQMDNRMQS--YGAVPEALDACAKAADLMAEVIGALTFDAARARALLADGACFASDlvDFRSAhlVGRLVTRLEQEGRTLASLSQSepAVPDGLLAEAFDPKAClgAAPAQVRR------
    398 UniRef50_A0QIE8        3-carboxy-cis,cis-muconate ...   197     1e-48  1  14.1%  44:411  18:368     -------------------------------------------DAALLDAMVAVESAWLAALTGAGLAPADCAAAGLRNL---------VAGNDFETLAVGAEDGGNPVI----------GLVRLLRERADPAVAPWIHRGLTSQDVLDTALMLGVRALADDLIAELREQIRVLSGLTDRHRATHMVARTLTQHAAPTTFGAKAAGWLNGVLDAFDNVIALVTPVQIGGAAGtaLRTGTVDPAAVSVELARGTAAALGLAPRP-----PWHTARAPITAAADALVGCTDSWGRIAADVVTLARPEIGELGE-PATATRGGSSSMPHKRNPVLSVLIRRAAIAGPPLAATLHTAAALAGDERPDGAWHAEWDTLRTLGRRTAVAASQCTELLAGLSVHAARIAENLAAADVL-------------------------------------------------------------------
    399 UniRef50_Q1GJ78        Fumarate lyase n=4 Tax=Bact...   194     9e-48  1  14.0%  40:395  22:348     ---------------------------------------ALFEGAATADAFLAYEMALTRAAAEVGQIDIGLAQRALAAMVDFTPDVAELQSDLSADG------------------MAVPGYVRQLKAHVGAECVAAVHPGATSQDLIDTAQALALRAANEIYISRLTTLIDALRDLEETHGDNRLMGRTRMQAALPISAGHRISSWISPLVRHTSRLEILRPEVEALQFG-GPVGDGQRSQPH-----AAAMADHMGKALGLRAPERCWHTERDSLVTYAGWLSALTGSLGKFGQDVCLMVQQGVDALAQ----AGGGSSSAMAHKQNPVTAEMLVTLS-RYNAGQVALMHQASVHEQERSGAMWTLEWMVLPAMMTCTGAALRLATRQVQAIT-----------------------------------------------------------------------------------
    400 UniRef50_C8NQR2        3-carboxy-cis,cis-muconate ...   194     9e-48  1  17.1%  43:405  20:346     ------------------------------------------SDEAFLTGLFTVEAALSVAAARAGALSDAEAATAVETIR--------NYQPDLEEISRQSAEGANPTIPVVKALKAIDPTG--------------IHPGATSQDIIDTSLMLCLRDATGEIIADLGELAELLAELTRTHRDTPMMAHTLGQQAVPTTVGCITAGWLQAVLRSRAALQELRFEVSY----GGAAGTMTATHPHGFAIQDE-LAAELGLH----NSGLVWHSDRIPVTTIAAALATAAGAVRKIAGDVIFLSASEISELREAQP----GGSSAMPHKANPAAAIACDGYARRVPGLLATLFDALDC-RLQRGTGSWHAEWQTIRELAAATASAVGRCRRSIDGIVVDTGRMREHL-------------------------------------------------------------------------
    401 UniRef50_A2BJL5        Argininosuccinate lyase n=1...   193     1e-47  1  17.9%  37:467  20:410     ------------------------------------YTSSIGHDNEIYTYVVYILIAHTLHLYRRGIIPRRAACLTLRVLLEALEKKP-----------GELLGPGYEDVFEALEDWLAQKTGGESA---------YIWIGRSRNDHVSAALRLYTINKIIDTLYWLLQARLRLIELAEKHRGAPVLFHTHQQPSQLATLDCLLLAWEEALASAYKLLYSVIGLVDRSPLGASAGAGTLA------PIDPEELARLTGFSGVL-GNSLYATGSRLDVTAAALAATALLVEASRIAENLVLLSTPYVSAVRIP--ESHVATSSIMPHKRNPVTLEVLRARAARAAGLAAGLLAIQKGLPYGYNLDLQEAN-PLLYTILRDAAESSRILADLFSSMEFDLERLSKLAESYIAWGAELAELL-----------ALRTGMPLREAYReaMKLRDGKISELFQKLGVTSPSE-----------
    402 UniRef50_C6WLF2        Fumarate lyase n=5 Tax=Bact...   192     2e-47  1  14.6%  19:463   4:440     ------------------LTGRLSAAPSTLLDAEVLRPQFEHEVRRLLPHYVAVERVLALEYRRMGLLTEEQAADVLGLLARVRPDELAADPEANLSDIAFALERHVER--------------------GAARPVPNWHVDRSRNDLQACAQLMAARDRLAALAGQVLGMAAAARRVAARHLDTPMPGCTHYQAAQVTTPGFHLAALGERLLHTSRRLLATFDGTDACPLGAGALTGQ------HLPWDRERMAALLGFT-RPGGSALTDVASRAFVAEITAELSLFGITASRFATDLITWAGAGHGFVDLP--DELSGISSAMPQKKNFPVLERIRGRTAHLTSCHVDVALAQRGTPYTNLVEVSKEAGAQFHDALDTAGSVVRLFTAVLDGLVFRADRMRAACErgFALATLlvPWRRAQvaGRYVVAALERGLplAAVAEADGVTApaLLAEAFDVDASL---------------
    403 UniRef50_B9NWJ1        3-carboxy-cis,cis-muconate ...   192     3e-47  1  15.4%  46:395  28:348     ---------------------------------------------AQLDAMLDVEAAYPKALAQCNLCQKDLADRAVHHIRSV----------PLSIDDLRIGTKRD--------GLAIPQLVRQLRANADADVAAVIHTGLTSQDVMDTALILTLKAANQLFRQRLEQLEQTLTDLDRRFGENKMTGRTRMQLAHGIRVHDRLGIWQRPLVEHQCRLTEIESRLLRIQLG-GAVGDRAAWQGAG-QNVADALAKLLDLAPAGT----AWHSDRSALVEYAGWLALVTGSLGKIGQDISLMAQQGI----EEISIAGGGSSSAMPHKQNPIGAELLVAMA-RFNATLVAGMQHSMVHEQERSGAAWTLEWMLLPQMVMATGSALNAASDICARIT-----------------------------------------------------------------------------------
    404 UniRef50_A3ML08        Argininosuccinate lyase dom...   191     4e-47  1  14.4%  44:445 473:857     -------------------------------------------PLAELDHLFDLNEAHLVMLGATRIVAPERVRPLLDAHRRLRRAGYAPLLARPRPRG----------LYMLVEAYLIETLGE--------DVGGVLQTGRSRNDINAATTKLHLRDATSRAFDALWRLRRSLVFKASANVDCAFPIYSQYQPALPGTLAHQLLAFDGALAHETHALFALFQHIDVCPLG------AGAGGGTTLPIDPEFVCRLLGFE-QPAPNSLDAVANRSGVVHFLSAMNAIGLVLSRLAQDLQIWTTAEFALVSLP--AALTGGSSMLPQKKNPFLVEFVKSRAGVPFGALASCSAALGKTPYTNSFEAGSPMNGLIAQACAAIEDAAAVAVLLIDGLEAAQARIDAHLRDTGVVAMAVadFRSAhrVAQAVRDSAAQGRSSHDALAAL---------------------------------
    405 UniRef50_A1TNJ1        Argininosuccinate lyase n=7...   191     5e-47  1  14.2%  48:478  65:499     -----------------------------------------------FFWLGEINKASAVINIDQGLLDKSLAPLVHGGISKVLADGNRPGGKRPRLVITF-------------EPLLIEAAGPQITL---------LHAGRSSQDMLSTVRAAMLRDQMLQLAEALNQTTATMVRLADRHQATVVPNYTNGVAAQPNSYGHYLLGLASGLDRDAQRIREAYARIDRSPMGTTVLNGTS------WPLDRQRMADYLGFS-ATVDNAYDavSAVDQPVEAGAIVMAIALHAGSFIEDVMTQYAQPRPWILLQEGGGNTYVSSAMPQKRNPGLLNATRRDASQALTLGMGAAIQAHNIPPGM--QDPKEARNN-TAMVQSAIDVLRQWDRILGALVIDPQRALEELnaSQELADVLmpFrgHHFASEAVGYAKAKDIKPLDFPYAEapMDEAEFRATLDPVAIvgPQPAEMARMLKAAQ
    406 UniRef50_C2ANG7        Adenylosuccinate lyase n=1 ...   190     8e-47  1  16.6%  43:471  21:433     ------------------------------------------DDTAVIGALLEAEVAW------IGVLDGVESE---RAAALVVESRRSAGAFDPTRLASAARSGGNPVIPLVAELR------------EYLGSAMPVHRGLTSQDVMDTALMMLARRVADEVAEDLAAVSAALARLADEYADTSQVGRTLGQFAVPITFGAKVAGWRQGIDGAARRLAAAGTPVQ----CGGAAGTNAAVVAMGVDPVqaQWARKLAL-----TPSEPWHTSRGPVAELGDALAAVCAAAGRIANDVIQASRPEVGELAESAVDRG--GSSTMPHKRNPVLSVLIRAAALSAPGHAGVLQLAAGQAEDERSTGAWHAEWPALRSLLRLALGTAESLRELCEHLRVFPDRMAQR-------VTAAAPLLVSERLMIVLAERARGGRalReiSGAVPGLTAAELDELLAVDGYLGTAPQRAR-------
    407 UniRef50_B6R3I0        3-carboxy-cis,cis-muconate ...   190     1e-46  1  14.2%  39:396  21:349     --------------------------------------QSAFSLEATLQHYLAYEVALTNALSEHALILPEAKEAILKGC-----EGFEPDLAALKAGVAKDG-------------LLIPAFIAQLRARIGEPHAAACHKTSTSQDVMDTTLALTLKQVSQILASRLAAVIGALETLKSANAEHTLMGRTRMQVALPITAGDRIATWIAPLKRYQQKLEDIAKQVSVLQYG-GPVGTSSTQGEHAEAIASQMAAEllG-----VPNQ-SWHTQRDNLVDYANVLSMISGSLGKLGADVTLMAQQGVGEIRLT----GGGNSSAMAHKHNPINAELLVTLA-RYNSTQVSAMHSALVHEQERSGAAWALEWMTLPGICMATGAGLQSALKLLQQTEW----------------------------------------------------------------------------------
    408 UniRef50_A1TFG6        Adenylosuccinate lyase n=71...   189     2e-46  1  15.6%  40:476  37:471     ---------------------------------------AIWSPEAKIVAERRLWLAVLKAQAELGvvPDGVVADYERVLEEVDLASIAARERVLR--------------HDVKARI---------EEFNALAGHEHVHKGMTSRDLTENVEQLQIRRSLELVHARGIAVVARLAERAALYRDLVMAGRSHNVAAQATTLGKRFASAAEELLVALQRVRELIDRYPLRGIK-GPMGtlFDGDTDRLADLERRVAGFLGFTDIF--TSVGQVYPRSLDHDVVSALVQLGAGPSSMAHTIRLMAGHE---LVTEGFAPGQVGSSAMPHKMNTRSCERVNGLQVVLRGYASMTAELAGAQWNEGDVFCSVVRRVALPDAFFALDGQTETFLTVLDEFGAYPAVIQRELDrtRILIAAVRAGVGRETAHEVIKeaMREKgdLLDRLAADppLDRQALDAAldKQVFTGAAGDQVDRVVAA--
    409 UniRef50_B6WB77        Putative uncharacterized pr...   188     3e-46  1  20.2% 205:456   1:253     ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MAHFQRFKRDSEKFMELFKRLQENPLGACAMAGTT------LPTDRFITTKLLGFD-KPTENAMDTVGNRDNIMDYLYLSSLTMTHISSIAEEFVVFNSQEFSFID--IDDGYCTGSSIMPQKKNPDLAELARGKVGRNIGNLINLLTVVKGTFLTFNKDFQEDKEALFDSIKTLNMSLLIF-EKMLEGSHFKEEVLKKHLeeATDIAEYLvpFRSAHevGNLVKYCENNNKDFSQINKKDLEifPVKLDDL----------------------
    410 UniRef50_C7MHE6        Argininosuccinate lyase n=1...   187     7e-46  1  16.5%  48:478  44:464     -----------------------------------------------LPAMVEASLAHVVMLRETGALTEQRADRLLGGLLTLWRRwaQPGEDWRPRVTSHPFDGSVEDPYYYLEQQLAAACGISTSDLD-------VQLARSRNDLDAGVFRMILRRGILDLAELLLQAVRDLEEAAARTVDALLIGHTHRRPAQPTTIAHVLSGLAEAFLSQAEELLSVYDEMNVSPLGSAAFTGT------DIAIDAQRVADLLGFSSSFTA-SYEAVAGAEHFMRLAGLHARIASTGARWARVLQEWMN--LGWVRMP--DEFTQGSSIMPQKKNPVVLEHLVSMSGAANGETNAVYTTIAAGWYEDSNNATTDVQKHLWSSTERIIRFVRLIDGLTLEIEpdEDIVRSGaaVAEALATHSVPWRSAHDV---VGTLFRQGDptWDEGQVEAALAEAAIDDDGRLRDLVLSSGRDPRRILEREQ
    411 UniRef50_O49514        Adenylosuccinate lyase - li...   187     1e-45  1  14.2%  18:476  77:462     -----------------PLDGRYWSKVKDL--------ASSLSEFGLIYFRVFVEIKWLLKLSN---IPetEVPSFSKEAQSFLQGIIDGFSIDDALEIKKIERVTNHDVKAVEYFLKQK----CESQPEIAKVLEFFHFACTSEDINNLSHALMLQEALsvILPTMDELIKSISLIAKNFAYVPMLSRTHGQPATPTTLGKEMANFAVRLSEERRYLSETKIKGKF----AGAVGNYNAHISAYSNIDWPHVSEelGLTFNPYVTQ---------------------------------------------TTKAGEIGSSTMPHKVNPIDFENSEGNLGKANAELTFLSMKLPISRMQRDLTDSTVLRNMGGALGHSLLAYKSAIQG-IGKLQV----MRR----------YGVPE-PYEKLKELTRGKAVNEETIRTFIKGLELPSEAK-DQllTPHTYVGAAAALALAVDEA--
    412 UniRef50_D1VC10        Fumarate lyase n=1 Tax=Fran...   185     2e-45  1  14.4%  46:414  20:367     ---------------------------------------------AWLTAMARVEQAWLDALARAGVAPASA---------ELTGLVGPAELAAVARAAEDAGNP-------------VPALVALWRERAVGPGAPWVHRGLTSQDVIDTSLVLLLRDVVDRIRAQQRDQVGALAALAHTHRGTLLAGRTLTQHAVPTTFGLKAAGWLTGVLDAAE----ALDRVALPAQFGGAAGTLSAahADPVAAVSGAVADAT--AALGLRPARPWHTTRTTFTALGDALVAGTDAWGRIATDVATLSRPEIGELAEPAVP-GRGGSSTMPHKRNPVLSVLIRRAALTAPALASTLHLAAALAGDERPDGAWHTEWPTLRDLARRAVVAASHTSELLRGLEVDTARMRATARAAWPLLTA----------------------------------------------------------------
    413 UniRef50_A9HXU4        3-carboxy-cis,cis-muconate ...   185     3e-45  1  15.0%  35:442  19:411     ----------------------------------PAGDIGLFSDQQWLDALLRFEAALARAQASAGLVPASAAAA-----IARACASIELNRADFVERARGTGAFGIGLVDPIRAFLA----------SHDPAALPCLHWGTTTQDAVDTAHAVLTKTALAALLDELQKLAAALRALAHAHAATPMMARSLLQPAQVTSFGFKCAQSAGALQRSASQLCTLAPHALCVQLG-GAVGNRAAMGHR-AAQVELVLAAELGL----WASGQSWHTQRDAWMRLAMEASVCAGSLSKLARDWSLMSQFEVGELAEAP---RGRTSSAMPHKRNSVHCMQAIALTQPVPG-LAASLLGAMTQAHERAMGEWQAELSVWAPLWRRVHGAAAALRLAADGLRVDAARMQSHIDasEACTDALAPITGREAAQqlAPQALAQRQPLSALL------------------------------------
    414 UniRef50_A3VZD3        3-carboxy-cis,cis-muconate ...   182     3e-44  1  11.1%  40:390  21:340     ---------------------------------------ALWSPETQLHHMLRFEAEWSRALGHVGRIDARTADETARHILTTTPDLTALAAG------------------TARDGLPIPALVRLLKATAPDPTA--VHQGATSQDVLDTALALTLQATTKLLDHRLASLQSALADLDTRFGSNPLMGRTRMQAAMPIRVTDRLRPWITPLTTHRSRLARATDGVALLQFGGAA-GDRAAMGADAPRIAAHLAA-----ALGLGNPPTCWHATREGLADYASTLSLISGTLAKMGQDVALMAQQGIDEIHLT----GTGTSSAMPHKQNPILAELLVTL-GRFNAVQVSALHHAAIHEQERSGTAWALEWMVLPQMAQATGRALTAALDL----------------------------------------------------------------------------------------
    415 UniRef50_Q3DQ38        Argininosuccinate lyase (Ar...   180     1e-43  1  13.2%  19:252   4:214     ------------------NHKLWGGRFESSLEKWVefGASISFDQKLAPYDMKASMAHVTMLGKTDIISQEEAGLIKDGLKILQDKYRAGQL---------TFSISNEDIHMNIESLLTAEIG---------EVAGKLHTARSRNDQVATDMHLYLKDKLQEMMKKLLHLRTTLVNLAENHIYTVMPGYTHLQHAQPISFGHHLMAYYNMFTRDTERLEFNMKHTNLSPLGAAALAGTT------FPIDRPY----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
    416 UniRef50_D1S4X8        Argininosuccinate lyase n=1...   180     1e-43  1  16.3%  42:471  19:443     -----------------------------------------HHVAHLYPAMVTASKAHVVMLAEQGLISDDAAATMLRGLVALAADRPEELEYD----------GSVEDVYYTLEKRLAAAAGIEVSQLS-------VQLARSRNDLDAGVFRMVLRDQLLQVLDALLATGRTVLDRADRHADVVITGYTHRRPAQPTSIGHVFAGYAEALAGEAAAYAGLLDEMNRSPLGSCAFAGT------DLDISPRRLADLLGFD-QLIVNSYEAVAGADHLVRVATLNAQALATGARLARTLMDWLSWGWV----VTPGEFTQGSSIMPQKRNPVVLEHLVSMAGAAAADAASVLNNVGAAWWEDSNNATTDVQSRLWDGDDRAYRFFSLLGGLIDKLDPQRPPSGEEiaAADALARHGVPFRGAHslGRLVrtAADLGLALDDAAVRDLLAAAVRPELVLRRAQADGPGEAAVR-------
    417 UniRef50_UPI000185BF09 adenylosuccinate lyase n=1 ...   177     7e-43  1  15.6%  37:471  19:451     ------------------------------------TLAELWSPEYKIILERKLWIAVLKAQVARGivPEGTIEAYEKVIDQVDLDSIAARERI--------------TRHDVKARI---------EEFCDLAGTEHIHKGMTSRDLTENVEQLQVLQSLKVVRDKAVAVAARTAEKASEYQSLVMAGRSHNVAAQATTLGKRFASAADEMLLGIERVEDLVSRYPLRGIK-GPMGtlLDGDESALASLENEIAEGLGFDRVF--DSVGQVYPRTLDFDALSALVELGAGPASLATTIRLMAGNETVT---EGFKEGQVGSSAMPHKMNARSCERVHGFQVILRGYMTMISEYAGTQWNEGDVSCSVVRRVALPDAFFAMDGMFETFLTVLSEFGAFPAMIDRELErtKILMAAVRAGMGREEAHEIIKeaVATALDMREKGAEQNLTERLAADERfnRHAFIGAAESQVD-------
    418 UniRef50_Q2K050        3-carboxy-cis,cis-muconate ...   177     7e-43  1  15.8%  42:395  35:354     -----------------------------------------FSAEADIRAMLSFEAALARAEAAHGLIPAEAARKIAEACTGFSPDLASLRSA------------------MAKDGVVVPDFVKQLRAKVGEEAGKNLHLGATSQDVIDTSLMIRLKAVVFLFAGRLSAIIAALEGLDRQFGGNRLMGHTRMQAAIAISVSDRLNVWRAPLATYRDRLT---EQSFPVQFGGAA-GTLDKLGPQG-PAVRASLAQELGL-----SDTRQWQSARLPIADIAGLFASISGSLGKIGQDIALLA--EMGGEIEV---SGGGASSAMAHKQNPVAAEVLVSLA-RFNATALSGIHQSLIHEQERSGAAWTLEWLLLPQMTMGTAASLRLARELTGNIK-----------------------------------------------------------------------------------
    419 UniRef50_A8NWV8        Adenylosuccinate lyase, put...   176     2e-42  1  14.5%  41:469  28:414     ----------------------------------------ILSERNRVLIWRQMWIWLAEGEMQLGL--------------------KQVTEEAIEEMKKSKEVIDWGTIRREEKRIKHDVMAHTYAFGkcPKAKGIIHLGATSCFVQDNADLIVQRQATDYILKKLAVCLSRMDDFAEKTKDIVTVGRTHYQTASLVTVGKRAAMWAQELLMVFTKLEHFRENMRFRGVK-GATGTQDSfdEAKVDKLDELIMKSAGFASRFYISG--QTYSRQQDCDLVNIFALLGAATKKICTDIRILQA--FGEVFE-PFESEQVGSSAMPYKRNPIKSERVSSLARKLMSAPQ----------------------------------------HIVEGLTVDKERIEYnlEKAMMLLTEEGADraYEKIREVTLAAKETQK--RERVDLESILANVFFDKVRdpLCFTGRSSSQ---------
    420 UniRef50_B7AAC8        Argininosuccinate lyase n=1...   175     2e-42  1  17.8%  46:478  22:425     ---------------------------------------------ALVPHFFDALTAYALELARLGL---PHAKEAVAALRELRTLPLP------------SFTGEVEDVFFSIQ--------AQLAEHWGEEVAGAVRRGLSRNDLDLTVFRAYLRDRTLALLGDLLRLRRAVLRLAARVEGVVVVLYTHHRPAQPSTLDHYLLGVESLLSRDTERLFRALSNVNRSPLGASALAG------CPYPVDRRRLAALLGFEG-PVENTLDAVASGDYALELAAALQTLGASLSRLLTDLLFWAGRGAFLVGE----GLSQGSSLMPQKQNPVVLEHARIYAGRLMGSLEALAFLNHNTPFTDLNDHST---GVLEPLAAALEAGEAALELT-------RAALEEGAFVQKALMEELSPEV---LASEAVDLLVRKGIPLPEAYreLLGVDREELLSWVSLPAFlgVGPKARAQALSRAK
    421 UniRef50_UPI000038E105 argininosuccinate lyase n=1...   175     3e-42  1  16.0%  21:408   2:358     --------------------KIWSGSAAPESGnyRIMLEkiDVDKYLIPYEILSLMAYNLNIYERNISDRNNSKATLKELLSLYNRKISLD-------------PDLEDVHGNIENIAI---------RETNGAANNMRMFMSRNEQVHTDVNFFLIDILLEYEKIIYNTITGLEKL---TQNGIMPGYTHYRQGMPVTFQTYVDFIKNIMVYNFNNIDSILNELKELPLGYG-SGFGSMSDANF-----KEVAEYMGMKKQIKNPLFSFMLYSDNYIKVLSAINSFLIDISRIFQDMIIFSGDEMKIIELP--AGYVTGSSLMPNKVNPDFLEIFQGYAAKSISLMNLLYSGTINKTTGYHRDFQILKDEVIPFMVEL-KCVLNGFPELFSGIKFNKEASERIIGNS----------------------------------------------------------------------
    422 UniRef50_B0SV88        3-carboxy-cis,cis-muconate ...   174     5e-42  1  14.8%  40:397  17:349     ---------------------------------------AVFGDEALLRAALRFEAGLAQAQAEACL------IAAEDAEAIAAACVALPDIADLAQAAAHAGTLAIPLVALLRERLAT----------ASPRAAALLHKGATSQDLADTALMLQAKAGAALIRIETERLVTALTALTQAHATTPMLGRTLLQGALPITFGLKTAGWLQGVVGALARFE-TETAAIQLQLG-GATGSLAGLDGKAIEI-AERLAAILDLPAAVTP----WHARREGLAGLASALAILTGAVGKIAGDIALLAQNEVAEAFEPRV-AGRGGSSAMAHKRNPTGCQTALTAAIRAPHLAATILSALP-QQHERGLGGWQAEGPVLADLFQLAHGALAAMAPVVEGLEVD---------------------------------------------------------------------------------
    423 UniRef50_C4RMS6        Argininosuccinate lyase n=1...   174     1e-41  1  16.4%  38:408  16:357     -------------------------------------PTYDHHVGYLFAAMVRASQAHVVMLTERGLIPAERAARLLRGLAELRADTGPAPEFD----------GTFEDTYHLLEKRLADACGVPASELD-------VQMARSRNDLDAGVFRMLLRDQLTGVLDRVLATGATALAAAERYAEVVITGYAHRRPAQPTTIGHALAGYAEALAGQAVAYADLIDALNISPLGSCAFAGT------DLDIDPARVAELLGFAG-LVTNSYEAVAGADHLVRVGTLNARSLATGARLARTLTDWLTW-----RWVTTPGDFTQGSIMPQKRNPVVLEHLVSYAGATAADAASVLNNVGAAWWEDSNNATTDVQVRLWESNDRTYRFFALLGGFLAEIEPLEPPSREEIVAS----------------------------------------------------------------------
    424 UniRef50_A4EGL0        3-carboxy-cis,cis-muconate ...   170     7e-41  1  16.2%  39:395  20:342     --------------------------------------ASIFEPEAELKRLLRIEAAWMRALGEIDGIDAS---------DHIAASIEAAQIDPQALKAG-----------MTEDGVPIPILVRLLRKHLRPDQATHVHQGLTSQDVVDTSLILALVQVLSLLKERLGLLDQHLAEKQRAFGNRSITAFTRMQPAMETTVHEVIDRWRQPFAELIEDLSDLQNKVGVLQWG-GPIGARAHVQADALG---ASFAQHLGLK----DPGRDWHTDRTVIVKVTQLLCRIATVTGKIGDDIVLFA---ITGSDHITFEGGQ--SSAMPHKNNPVKAEALVALADFAAGLAATALRSARHEGF-RSGRAWMLEWLTLPQLCVTAGAGVRLAKHTLHDIT-----------------------------------------------------------------------------------
    425 UniRef50_A8HWY4        3-carboxy-cis,cis-muconate ...   170     1e-40  1  14.9%  48:390  30:338     -----------------------------------------------IRAMLAFEAALARAEAIHGLIPAEAAETIATVCVQFQPDVAALARGVASDG------------------VVVPALVRALRAAVGPEAAPHVHRGATSQDVIDTSLMLRLKPLAARFCTRLGAILARLAALDAAFGERALMGHTRMQAALPITVSDRLRSWSGPLAPLMLRL----DRLSFPVQFGGAVGTLEGLEGKG-AQVRAALAAELDLEDTP-----QWHSTRTVITDLGHLLALITGGLGKMGQDIALMAQA-----GDDITLSGGGGSSAMPHKQNPVAAETLVALA-RFNAVQASALQQAMVHEQERSGAAWTLEWLTLPHMLAATGAALRHAEAL----------------------------------------------------------------------------------------
    426 UniRef50_D2SFW6        3-carboxy-cis,cis-muconate ...   169     3e-40  1  13.9%  43:475  18:431     ------------------------------------------SDDAWFRALLDVEAALARAAARTGVVPTTAA-------DAVAAACAHPERLDLATVVARAADAGNP----------VPPLVRVLQDAVGERDAVAVHVGATSQDVLDTALLLMARNAVAAVDADLAAAADTTADLAHVHRDDVLAGRTLMQQALPTTFGLKAAGWLAGLDGARLRLAEVVASLPV--QYGGAVGTLAASGGAGV-VVRAALAEELQL----TSTAVPWFTVRLPIADLAGALGAAAGVVATVAVDVVLLAQT--EVAEVVEVGEGRGGSSAMPHKRNPVAAISARACARRAPG-LVATLLSAMEQEHERAAGAWHSEWPTLTELLSTVGSAASWLAESLRGLRPDPPRMAATAAAAAEGPLalGKGAAHDAAAAAVREARDGGRPLAEVVAARTDVDVRAVLAAGRPD--VGEAGAQVDTALA---
    427 UniRef50_A9DHF9        3-carboxy-cis,cis-muconate ...   167     7e-40  1  12.9%  38:394  18:345     -------------------------------------IAALFCDQAQLASFARFESALLLGLAKAGRIDKQDAAALIAQIK---------TFAPATGRIAEAAVSDGVPVPEYV---------RQLRNHVSGPGAEKLHFGATSQDLVDTATIETLAKTISILSKRLDQLITALEAMTARDGNNALKAITRMQEALNIRASSRLAGWRLPLEALRDRLPAVREQVMVLQFG-GAVGDLQTLSDD-ADTVAKAIASDLGLRW----PGHSWQTSRAPLIAAASWMTELSGALGKIGQDAAIMALRGKSDLEL----SGGGTSSAMPHKQNPVAAERLVAFA-RFNASQMGAMHQAQLHEMERSGAAMTLEWMILPQICETAGAGLTAAIALMQSI------------------------------------------------------------------------------------
    428 UniRef50_UPI0001B4D80D 3-carboxy-cis,cis-muconate ...   167     1e-39  1  18.0%  44:349  36:317     -------------------------------------------DRAYLRALLDAEAALTRAQAALGLAPAEAA-------DAVGAVAADPAAFDARSLAERARGGGNPVIP----------LVADLTKAVGEPYGPYVHRGATSQDILDTATMLVAARTLDLLLPDLARTERALARLAAEHRDTPMPGRTLTQHAVPTVFGLKAAGWRALVLDARDRITAVRDALPA-QLGGAA-GTLAAfgATDPTALPAAYAGELGLRA----PVLPWHTLRTPIADLAGTLAFTAGALGKIAVDVLTLSRTETGEVAEGGGGGSSA----MPHKANPVRSTLIAAAARRAPQLAAT---------------------------------------------------------------------------------------------------------------------------------
    429 UniRef50_D0REI0        Fumarate lyase n=1 Tax=Bruc...   165     3e-39  1  15.8%  40:350  23:300     ---------------------------------------SLFTAYADIAAMLKFEAALAGAQADLGIIPAHAAERIMSATETMEPDLAQLEHG------------------TARDGVVVPALVRNLRKTVGEDVAAHVHFGATSQDVIDTSLMLRLARVRDILVARIEQLSERFNWLETTFGQNDLTAYTRMQPAISTTVADRVESWRAPFSDYAQRLAALQ---FPLQFGGAA--GTLEKFVGKGAKLRAELAKRLGLEDRP-----QWHSQRAFIADFGHLLSLVTGSLGKFGQDIALMA-----ELRDEISLSGGGGSSAMPHKQNPVRAELLVTLHGSMPCRFQGC--------------------------------------------------------------------------------------------------------------------------------
    430 UniRef50_Q97A54        Argininosuccinate lyase n=1...   161     5e-38  1  12.6%  32:436   1:389     -------------------------------MKIWQGGAAKPSEYDPMEYLVKLDVSADTILEKYEIInaYHYELIKIGIINEEDGKCLLNALIKAYEGKITIDVKDEDVHTAIENWV---------KGLCPKNWENLRLFLSRNEQVHADMILYLLDSFYKMNKIFQSCIEKTIGV---NGEGYLPGYTHFQQAMPFTFKSFMNSVLLLLERNILNVHDFFQKIRINVYGYG-SGYGSPISAKF-----DKMGELLGLRYDHKNPIFLSSLYPQTLLEASQLIVTIMMPLSRLSSDTINYYSRGIMDIP----DEFTTGSSLMPNKRNPDYLEMIQGLAAESVGVSSSIASIALNKQIGYHRDFQIAKDSIVFLIEKLIAH-LDHLPDLLGRIEFFKEASERAVEnsYATMNAWNAfrWKEAYARIGNMVRENNE------------------------------------------
    431 UniRef50_Q9HKF2        Argininosuccinate lyase rel...   161     6e-38  1  13.6%  21:396   2:344     --------------------KLWSGGIQraDSTVAFVKRDIEAEIYLMKYEILSLIAYHLDLAQRRLITEAESKCIINSLISLLQDSPKID-------------PEQEDAHTAVENAVIERCG---------DMGRNVRLFLSRNEQVHANVLMFTIERCHSIISILLDSIKVLKG---ADLKGLLPGTTHFMPAMPVTAATYSNYIENSLALAIRSIDRSLADASVLPYGYGSGYGSPNSGKL------KVMSEMLGIGPVLKNPMIASSLYQFTIMQISNSIAGLSITLSRIAMDLIEYYRDGYVSLS----DEFTTGSSLMPNKRNPDYLELLQGMAAVSSSVAVMSAMATMNKTSGYHRDFQMLKDSYIDMLNYIEEALLRL-PDLFKGLRF----------------------------------------------------------------------------------
    432 UniRef50_C9S9U9        Fumarate hydratase n=1 Tax=...   159     2e-37  1  34.6% 312:467 217:372     -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LNLPENEPGSSIMPGKVNPTQCEALTMVCAQVMGNHVATTIGGMNGQFELNVYKPLVIRNLLHSVRILSDGMRSFEKNLVVGLAANEQKIASIMQESLMLVTCLNPKIGYDMASKVAKNAHKKGLTLKESAMELNALTEEEFDTLVKPELMVGPAE-----------
    433 UniRef50_Q6PPG9        Probable argininosuccinate ...   157     1e-36  1  19.7% 281:478   1:215     ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LFVCALLMVHLSRLAQELILWSAPEYGYVE--LSDEHTTGSSIMPQKKNPDIAELIRGRSALAIGNLTGMLALLKGLPLTYNRDLQDDKPLLFATLDTVIPSV-TLMRQMLEKARWNTERMRAALQGDFSTATElvPFREAHavGGIVRECLQQGIALEDLTLehHPRFEADALEVIDPMHAigTAPEAVQQQIEQAK
    434 UniRef50_Q6L1N6        Argininosuccinate lyase n=1...   156     1e-36  1  12.4%  21:440   2:376     --------------------KIWSGSAGEELEnfnIIRDDIDADKNMIKYEIINMLAYNVAM--------KAPCSVIKALLDIYKNGIELKLD-------------LEDVHGNIEDFIIRRTGF-----------KNFRMFLSRNEQVHSDLNLFIIDKIIEIEKILYEIIKVIPGF-----NGRIPGYTHYRQAMPMSVNTYINYIKSIFYHHFNNLDSFLMDLREMPLGYG------SGYGSFSPVDFNQVSNLLNMEKNIKNPVYSSLRYIKNIENIVYLISSLAVDISRICQDIIIYSENDIITIP----PEYTTGSSLMPNKINPDYLELFQGISAESISMLSFIMQSELNKTTGYHRDFQIVKDRTISFINNFERIMLGL-KDLLYNIKFNEKNIKNDVYATYNAWLAFKNGMDWKSAYSYAGNKIKNGEVLDE--------------------------------------
    435 UniRef50_Q4UB18        Adenylosuccinate lyase, put...   155     3e-36  1  12.7%  18:473  10:398     -----------------PIDGRYYKYT------FKISDYL--SEYKIISNRILVEVRWLQYLVRLGITP-----------------IKSLSQESINELQNIIALDTKM-MHDVKaeYYIRKRFEVDGTPELKKLITWVHIFCTSEDINSPSYSMGIRDCMNYVVKPLmqIISTLCKLALENARMPMLSRTHGQPAIPTTFGKEVSTFVYRLSYQYKK--------CISNIG------LAMFKISSKYKLWHIL----------------------VYRNLDLNISLIQHKLS----VMILYQNCPIVF--------GEVGSSTMPHKINPIDLENAEGNLGLSNSLFHFFSTKLPMSRMQRDLSDSSVLRNLGVAFAHSVVAYNSILSS-LERMYFDESTSKLEIQENWNILSEPvkMMGheKVLVFTRGFNPSKDEMLKFIEENCGKDSRLL--TLKLEEYLGIAEKLAKNV-----
    436 UniRef50_UPI000187E7E3 hypothetical protein MPER_0...   154     8e-36  1  19.7% 254:451   3:200     -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AEILGLQDPP----ISWHVARDGIAECVSFLSIIGGTLGKIALDLLLLSSSEFGEVQEPFVP-HRGASSTMPQKRNSISSEVILA-CSKLLRQHASTAQDAMVSDLERASGPWHLEWSCVPEAFCAASGALKQTEFVLDGLVVDTQRMLQNLDMSKGlmMGLAPSLGRNAAHDVVYEACKSCIEEVNSTGEQGRLSDK---------------------------
    437 UniRef50_A1SC84        Argininosuccinate lyase n=2...   152     2e-35  1  17.6%  14:423   2:385     -------------SIEVPA-GYLGAesGPAPELIASGYTLETADAPLLHelGLADLAHVLALVEAGVVPASAAKDLARELLQILSTP--PEEFPYDPVYGDAYNS--------RERELESRIG---------DAAGWLHTGRTRREAGRIAFRIALRRKLLDLHDAVGDLALALASAARLHAETLWADTTYLQPAQPSTFGHYLGAFAEETTRHFDRIQAAHRWANRS------PAGSGGVGGSPVLVNRKRDAATLGFDEPGWHTR-DIMWSVDGLVDAVVSATQTAATVDRLAEDLEIFASPAFGYVR--LDASLCRASVLMPQKRNPYALAVIRAGAGVLLGR-TSGLMATQRTPSAR-TDNWLHAYGEVASSVDLATRLVRLGTAVVRSLEVDEEALARAAGAHFTGAADLAESMVLHQ-------------------------------------------------------
    438 UniRef50_C1H6L6        Argininosuccinate lyase n=1...   147     1e-33  1  13.2%  37:347   4:234     ------------------------------------YNESIYFDRAFHAQDIAGSIAFARANVATGILTKDEFASIENGLKQVLEEWRTNAFKIVP--------GVDEDIHTANERRLGEIIGK--------EIAGKLHTGRSRNDQVATDLRLWLRDELRVVETYLVDLLKVIAE------------------------------------RAESDIEYVMPGYTHLQRGQA-------------------------FDG-LIHNSMSAVGDRDFILETMQWGSTLMLHISRWSEDLIIYSTTEFGFVR--LSDAYTTGSSLMPQKKNSVPFRETHHIAGRVVALA-----------------------------------------------------------------------------------------------------------------------------------
    439 UniRef50_C2EB52        Possible aspartate ammonia-...   136     2e-30  1  41.1%   5:172   1:167     ----MRIESDSLGTKAVDDAAYYGIHTERARENFPVTSRPV--DGRLVRNLILVKEACANANAETGRLAADKHRMIVGACEAILDDfrFASELRTPAIQGGAGTSTNMNANEVIANLAAEMAGAKKGTYELIHPNDDVNMAQSTNDVYPTAGHMALVEYTTDLLDQLEKTRR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
    440 UniRef50_C9S992        Argininosuccinate lyase n=1...   131     5e-29  1  13.1%  36:302  11:229     -----------------------------------QYNASIQYDKLLFKEDILGSIAFARANAKSGIISKDEFTEIERGLREVQKEWEADAFVIM---------PNDEDIHTANERRLGEIIGK--------DIAGKLHTGRSRNEQVACDMRLWLRNQIEEIEGHLIALIER---------------------AMPVLWSQHLLSFGFYFANDLERLRETSKRVNRSPLGCGALAG------NGFNIDRDMMAEELGFADILWNSMNAGVPFR----ETHHISGRCVATSEKLGIPMNELS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
    441 UniRef50_C7Q1L9        Fumarate lyase n=2 Tax=Acti...   122     3e-26  1  14.8% 252:474 327:554     -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AFARELGL----AVPELPWHVLRTPVADLGGALAFAVGAMAKVAADVLVLSRTEVGEVAEGAA----GGSSAMPHKANPVRATLIAAA-ARQAPALAAVLFGALVAEDERPAGAWHAEWQPLRELLRLAGGAAEAAAGLVAGLRVLPDRMLDNLHrsERLAAEVSGVLGRGPAKQLLADAADrgTSLEDVLAdkGLISRDRLRRLTDPADYLGAAEALVDRAL----
    442 UniRef50_UPI0000510540 aspartate ammonia-lyase n=1...   119     3e-25  1  51.9%   1:135  24:157     VSTPTRTETDSIGSLEIPAAAYWGVHTARAMENFPIARRPVSVYPDFVRAFACVKQAAARANLEIGALDEQRANLIDAACEEIK-GGRLHDQFTVGVIQGGAGTSTNMNANEVITNRALEIGGHAKGDYSFINPN-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
    443 UniRef50_A5G1E3        3-carboxy-cis,cis-muconate ...   118     6e-25  1  16.3% 138:437 161:450     -----------------------------------------------------------------------------------------------------------------------------------------IHRGGTTQDIVDTGLILQLRDGFLLLEADLDAAAAAAARLARAHAATPMIARTLLQPALPATFGLKAAQWLAALDDARAALRDAARQALRPQLGGAA-GTLDGFGTRADAAATAF-AAALGLDPAPLP----WHTSRAPLARLAATLAAALGTAGKIATDTALMMQAECAE-AAEPAAPGRGGSSAMAHKRNPTLAVAIRAA-ALRAPPLAATLLAALPQEHERAAGAWQAEQSVWPELMRLASGTLAALAELLAGLTVDEAAMARNLAHAP--AASPSPAIPALIEAALAAHARQDRRP-----------------------------------------
    444 UniRef50_B4QQ61        GD12804 n=1 Tax=Drosophila ...   107     1e-21  1  23.2% 342:466  25:148     -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RYYGAQTMRCLINFRIGGEEERMPPLIASNVLRSIKLLADGCISFNCNCVKGIKPNKEKLAKIVNESLMLVTALNPHIGYDKSAQIAKAAHKNGTTLKVEALNAG-ISEKDFNEWVRPEKMLGPS------------
    445 UniRef50_Q069K0        Putative uncharacterized pr...   105     5e-21  1  17.0% 326:478   1:162     -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HKRNPEVCEQIVTLSKLVKANFYTSLDTFI-LEHERDYRGVRTEWVSITDSSMYLSKVLELIKFVLKGLKVNKENINRNLamSESLMFWLSKKIGKSEAheISMDIAENGGSVIDTIKSDYPQFDQEIDFVTDPYKYIGEADKIITNIKTKKR
    446 UniRef50_UPI0001BC98E5 3-carboxy-cis,cis-muconate ...   105     5e-21  1  21.4%  39:206  19:171     --------------------------------------REIFSDEGRVQGMLDFEAALARAQARVGLIPPEVVADIELSCDARL--------FDFDALAIAIGSAGNSAIPLVKAL-------GKQIAARSAEAERYVHMGATSQDVMDSGLILQLRRASVLLERDLTLLADAMAEQAQRHAGTPLAGRTWLQQATPVTLGMKIAG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
    447 UniRef50_A8V5Q2        Adenylosuccinate lyase n=1 ...   104     8e-21  1  13.0%  40:208  12:154     ---------------------------------------HVWSEVNKFQKWLDVEIAICRAWNKLGKIPDKALKEIEEK--------------------TYIDEKVVERIHELDKIYNHDVLAFVTAVAEQveNGRYIHLGITSSDVIDTALGLLMREAIDILLKDIDELLPVLEENAFKYKETVMMGR-------PMEFMQNLWFWA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
    448 UniRef50_UPI0001AF512B 3-carboxy-cis,cis-muconate ...   103     2e-20  1  14.5% 338:475   2:152     -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GAATRSPG-LVATMLAAMPQEHERSLGLWHAEWETLPELCCLVSGSLQQALQVIPGLQVDAERMRINLESTRGLVlaLAQRIGRDAAHHLirRAVEQGAHLRQVLGQNPQVSedELDRLLDPAHYLGQARQWVERAVA---
    449 UniRef50_C9YFZ0        Putative uncharacterized pr...   100     2e-19  1  10.8%  42:393  46:326     -----------------------------------------FGAQRFVAAMLRVEAALAQAQADQGLIPAEAAVSIVGTCKVELFDAPK-----IVRDSAATGSLAQPLVKSLRETVGL----------FNPAAVPFVHFGCTKQDLVDTTMALMTRQVLAVTRGYVQDCVDHLERKANK------------------------PTAAAPLKRALQRLAHSSADALAVQLG----GTMASLGTPGAAIQ-NQVAKTLELG----VPAFPWDTQRDAWLALGCDVALLVGSLGTLARTMVRDAEQEEPAAG----------------------CLVALAMARRAPQRAAGLLTSMPHA-HERGLGFWQADQSDWTQLLMAAHAASWGMAQTLQK-------------------------------------------------------------------------------------
    450 UniRef50_A8HRN2        Predicted protein n=1 Tax=C...    97     1e-18  1  14.2% 267:470  41:241     --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QFRAHPELAAVLEFTHFACT--------SEDINNLSHA----LMLKEAVQGHVGSSTMPHKVNPIDFENSEGNLGLANALMDHLINKLPISRWQRDLTDSTVLRNLGVGIGHALLAYAASLKG-ISKLQIDTARLAADLDNSWelAEPIQTVMryEKLKAFIRGQRVTQESMMTFVDGIDGLPEPAKEQllTPANYIGNAAQQA--------
    451 UniRef50_UPI0001909CE5 aspartate ammonia-lyase n=1...    93     3e-17  1  36.5% 351:465   1:115     --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TMAAEGGQLQLNAFEPVIVFNLLQSISLMTNAFYTLADKCVAGIVANEETCRHSLEAGTALATALTSLIGYEKAAELARQILSTGRTMRELLEEDSSLSASLIEQALEVKSLTQP-------------
    452 UniRef50_Q5ILH9        Plastid argininosuccinate l...    91     1e-16  1  12.4%  19:171  58:189     ------------------WGGRFTGATDPLMEKFNES---LPFDRRMWAEDIRGSQAYAKSLARVGVLTEEEASTLVDGLAAVAEEWAAGTFKVV---------PGDEDIHTANERRLSELVG---------PVGGKLHTGRSRNDQCVTDTRLWLTGAVRELRASLQALI-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
    453 UniRef50_B9XS90        Aspartate ammonia-lyase (As...    87     1e-15  1  37.7% 350:463   1:114     -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MTMAAEAGQLQLNAFEPVMAHVLFENLKWMTAAMTTLRVNCVEGITANRERLAREVDSFVGVITALIPHIGYGPAAKMAKEALASHANIAELVVKSGVLTREQVDTMLSPERLT---------------
    454 UniRef50_B6WB78        Putative uncharacterized pr...    87     2e-15  1  10.8%  22:188   4:153     ---------------------LWSGRFSKAMDEVtlYNESLSFDNVLYPYSILGSLAHVTMLKDCKIIDEDTYKKIKSGLIKVKEKFDKGEVE---------LDIANEDIMMLIEKELTNEIG---------NAGKALHTARSRNDQNALDETLFMREACLETLTRLKNLMEILIKKPRKKAKRLCLA--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
    455 UniRef50_Q1LB63        Fumarate hydratase, class I...    82     4e-14  1  37.5%    2:89    5:90     -SSATRIEKDSLGDVAVPADHLWGAQTERSRQNFRIGSEK--MPPALIEAFAILKLCAARANRELGVLKPDLADAIERAAEEVIGGFKS-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
    456 UniRef50_C2M913        Adenylosuccinate lyase (Fra...    81     8e-14  1  14.6%  18:181   9:157     -----------------PLDGRYASKTAPL--------AAYSSESALIRYRVRIEVEYLIALTQapALSKAITEPKQQALRQLYKEWSTEAAQEVKDIEA----TTNHDVKAVEYYIK-----RHLPQLGLEEIEEYVHFGLTSQDVNNTAFPLMLREALHEvlPTLQQLIEQLRQLANEW---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
    457 UniRef50_UPI0001555948 PREDICTED: similar to MGC81...    81     1e-13  1  19.5% 182:263  88:163     -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------QDVLFPGYTHLQRAQPIRWSHWILSHAVALARDSERLLELRKRVNVLPLGSGAIAG------NPLGVDRELLRKELTFGAIT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
    458 UniRef50_Q5C1G4        SJCHGC07580 protein (Fragme...    78     6e-13  1  12.5%  87:198  72:183     --------------------------------------------------------------------------------------FEITDEQIDEMKKQRDSIDFEIAASEEKARRHDVMAHVYTFALACPKASPIIHLGATSCFVGDNADLIMFRDALNILLPKGARCIDRLTKTAVLHKSLVCLARTHLQAAQPT----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
    459 UniRef50_Q12ZL4        Fumarate lyase-like protein...    77     2e-12  1  41.7%    2:85    3:84     -GSHIRSERDTLGEIEVPEDVYYGPQTVRTINNFKISRQRLPS--SFIRAQAAIKLASARANLEAGKLEPEIAKAIISAASEVRE---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
    460 UniRef50_C6THR4        Putative uncharacterized pr...    72     3e-11  1  30.6%    1:62    1:62     MALSFREERDTFGAIQVPSEKLWGAQTQRSLQNFDIGGPRERMPEPIIRAFGVLKKCAAKVN--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
    461 UniRef50_Q5EGG6        Adenylosuccinate lyase (Fra...    70     2e-10  1  13.8% 338:475   1:158     -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SLAKFIISLQSSGGLIATTQWLERTLDDSACKRLNIPQAFLATDAILILLNQIFSNIKVNERIIEKHVQTEmiLMKATKNGGDRQILHEkvKENLYSGknLIQLILNDkkLTSKDINEILNPNKNIGFASFQvdFIKE---
    462 UniRef50_A4NYC4        Fumarate hydratase n=1 Tax=...    69     4e-10  1  36.8% 108:183    1:77     -----------------------------------------------------------------------------------------------------------MNVNEVVANRAHVINGGKLGEKSIIHPNDDVNKSQSSNDTFPTAMHIAakKVVEHTIPCVERLQKTFAAKSEAFKK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
    463 UniRef50_Q2JGP8        Putative 3-carboxy-cis,cis-...    67     2e-09  1  10.9%  46:421  27:394     ---------------------------------------------AWLRAMLDVEAAVVRAEGRLGLVPAACVAAIDKAVAE-----CSADVERLATGGQWSASPVGGLVATLTETTR----------RIHPAAAEHVHRHLTDADVVAAASLVVATHVLALADADLQRVAAGLAELVDRRrsAVDGAGAPGRAAR--SLPTVAAGWLNDVLDARDRLARLVADGLPAPFE----GILTLQVPAPLAAAREEvaAVFAAEAGLSEPSLPWRGPRTILLDLMAFAVFVTSTAATVSAGMRRwaRPEPAGVRDAAAARHSAA---------AVDVMVISSAIRTPVLVVSLVHDLAAELWNDNDRheWETLRGALRALGGSAHAVAELVEhvTDGLFADPDRYRRAADAETEvaEAGGPGVGR---------------------------------------------------------
    464 UniRef50_C5WMD9        Putative uncharacterized pr...    65     4e-09  1   8.3% 113:196  54:138     ----------------------------------------------------------------------------------------------------------------IRYRVLIEWLLKLSHIPEITEVSEFFHFGCTSEDINNLSHALARKEGINRVmpVMIDICRALCSLATQNSGYPMLVRTHGQQEQ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
    465 UniRef50_A5ATU8        Putative uncharacterized pr...    62     3e-08  1  36.1% 298:369    8:74     ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VILFSXGKSLDLXENKPD-----SSIMPGKVNPTQCEALTMVCAQVMGNHIAAIIGGSNGHFELNVFKPLIA-------------------------------------------------------------------------------------------------------------
    466 UniRef50_Q6VRU4        Alpha-methylacyl-CoA racema...    61     1e-07  1  29.7% 314:387 199:270     -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LAEDTTGSSIVPGKANPRQCEAMAIVAAQVMGFCVAVTVGGGNGHFELDVFKPMMIKNL--CYTQAAGGCFSFL-------------------------------------------------------------------------------------------
    467 UniRef50_Q0FK05        3-carboxy-cis,cis-muconate ...    61     1e-07  1  12.9%  40:178  22:143     ---------------------------------------KLFSDSAEIRAMMIVLGTLAKVQGAAGVIPETAAKAIHRASLELQVDPRGLAEQAARDGSP---------VPALVEAFASLMQAPEYARYLLHDARP--------QDIEDSALMLRLRQALTLYGDELDTLLDQLAALA------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
    468 UniRef50_UPI000174365F argininosuccinate lyase n=1...    58     7e-07  1  17.4% 354:445   1:100     -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKALPLAYNKDMQEDKEGIFDSIDNIKLSI-EIFYLMLNTVTVNDEkmKSGFLNATDVADYlvPFRQAHkvGEIVSYCEDKKIAIDDMNLKN---------------------------------
    469 UniRef50_Q71IK9        Argininosuccinate lyase (Fr...    68     9e-10  1  16.2% 362:478   1:136     -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NKDMQEDKEALFDAIDN-VELCLETFIPMIKTLEANEKAMHQAAQKGFINATDLapFraYHISGQLVALCIDQDTVLEDLPLEtsDLFEEDLYQAIDLHNClgPTPESVQKQVDEVR
    470 UniRef50_B8P663        Predicted protein n=1 Tax=P...    42     0.050  1  15.1%   14:99 183:259     -------------TYQTPLSSRYASKEMA----------YLFSPANRFRAWRKLWLSLAIAEKELGliPDEAIEQMKANLDLDAAQFEIAAQEEKKRRH-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
        consensus/100%                                                                                      ..............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
        consensus/90%                                                                                          ............................................h...h.h...h.....t.t.h.....................................................................hp.s.oppp.......h.hh.....h...h..h.t.h...........h.sho.h..u....hs..h..h...h......h..............s.....................t..t.....................h...h..h...h.phs.ph..h...................SShhstK.Ns.....h........t..............t............h.................h.th....................................................................................
        consensus/80%                                                                                                ....................................thh...h.hphshh.h..p.shls.t.ht.h.t.h......................................................tthlphu.oppD.hssshhh.hht.h..h...h.th.t.h.ths.t..th.h.uhTph..A.Phphu..h..hh..h.pthtph.th...h....h.ssuhus.............t.hst.hsh......s.......ts.hhth...ht.h..th.+hst-hhhhtp..h..h......t.t.sSShMPtKhNP...E.h.th...h.s...thh........thsh........hh.th..hh..h..hhtthhtth.h..t.h.t.h..s..hh..h..hhtht.h.thh.....tt..h.t...t........h.........................
        consensus/70%                                                                                                        ............................thhpt.h.hphAhshh.tphGhlsttthttl.tsht.h.........................th....t.hh..hhh.........pssthl+hutoppD.hssshtlhhtptht.lhttl.tlhpslhthutphtphhh.uhT+hQ.A.Phohuh.hhsaht.ltcshpcltthhtph.h.shtusAhush.........h..thhsp.hGht...h.s.h..h.tpchhhphhthhshhshplt+hup-lhhhtpt.hs.lt....sthpsGSShMPpKhNP.h.Ehhpshshphhu..hshhhhh.sh.hphsht....t..hh.th.hhhtshhthhtthltslphp.pphtttht.s..hh.tls.hhshptstthstts.tpth.h.ph..tt..h..tthtthhp....h.............

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