BLASTP 2.2.22 [Sep-27-2009]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.


Reference for compositional score matrix adjustment: Altschul, Stephen F., 
John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis,
Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches
using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109.


Reference for composition-based statistics starting in round 2:
Schaffer, Alejandro A., L. Aravind, Thomas L. Madden,
Sergei Shavirin, John L. Spouge, Yuri I. Wolf,  
Eugene V. Koonin, and Stephen F. Altschul (2001), 
"Improving the accuracy of PSI-BLAST protein database searches with 
composition-based statistics and other refinements",  Nucleic Acids Res. 29:2994-3005.

Query= batch____
         (219 letters)

Database: uniref50.fasta 
           3,077,464 sequences; 1,040,396,356 total letters

Searching..................................................done


Results from round 1


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

UniRef50_P0AA37 Ribosomal large subunit pseudouridine synthase A...   456   e-127
UniRef50_A3MZ33 Pseudouridine synthase n=9 Tax=Proteobacteria Re...   290   3e-77
UniRef50_P59831 Ribosomal large subunit pseudouridine synthase A...   284   1e-75
UniRef50_B8K915 Pseudouridine synthase n=5 Tax=Vibrio RepID=B8K9...   257   2e-67
UniRef50_A7K2Y9 Pseudouridine synthase n=4 Tax=Vibrio RepID=A7K2...   256   3e-67
UniRef50_Q8DCG0 Ribosomal large subunit pseudouridine synthase A...   252   8e-66
UniRef50_C7LVL1 Pseudouridine synthase n=5 Tax=Proteobacteria Re...   233   5e-60
UniRef50_Q28K21 Pseudouridine synthase n=11 Tax=Proteobacteria R...   225   1e-57
UniRef50_Q2CAH0 Pseudouridine synthase n=3 Tax=Proteobacteria Re...   223   2e-57
UniRef50_A9CFZ5 Pseudouridine synthase n=3 Tax=Rhizobiales RepID...   221   1e-56
UniRef50_A0YGE0 Pseudouridine synthase n=1 Tax=marine gamma prot...   210   2e-53
UniRef50_B1Y046 Pseudouridine synthase n=43 Tax=Proteobacteria R...   208   1e-52
UniRef50_Q0VQA6 Pseudouridine synthase n=7 Tax=Gammaproteobacter...   206   6e-52
UniRef50_A4VJG2 Pseudouridine synthase n=18 Tax=Bacteria RepID=A...   206   6e-52
UniRef50_Q31HX2 Pseudouridine synthase n=1 Tax=Thiomicrospira cr...   200   3e-50
UniRef50_Q12L72 Pseudouridine synthase n=17 Tax=Shewanella RepID...   191   2e-47
UniRef50_C5BU65 Pseudouridine synthase for 23S rRNA and tRNAphe ...   191   2e-47
UniRef50_Q489H0 Pseudouridine synthase n=3 Tax=Gammaproteobacter...   187   2e-46
UniRef50_B7I1Q3 Dual specificity pseudouridine synthase n=17 Tax...   179   8e-44
UniRef50_A9BWX6 Pseudouridine synthase n=2 Tax=Comamonadaceae Re...   176   3e-43
UniRef50_A6VZC6 Pseudouridine synthase n=2 Tax=Marinomonas RepID...   176   7e-43
UniRef50_B0VCN8 Pseudouridine synthase n=16 Tax=Acinetobacter Re...   176   7e-43
UniRef50_A8UMR7 Pseudouridine synthase n=1 Tax=Flavobacteriales ...   174   1e-42
UniRef50_D0KW62 Pseudouridine synthase n=1 Tax=Halothiobacillus ...   174   1e-42
UniRef50_Q12RE8 Pseudouridine synthase n=83 Tax=Bacteria RepID=Q...   169   7e-41
UniRef50_Q6FCX9 Pseudouridine synthase n=1 Tax=Acinetobacter sp....   165   1e-39
UniRef50_C8Q1E7 Pseudouridine synthase n=1 Tax=Enhydrobacter aer...   164   2e-39
UniRef50_A0Y082 Pseudouridine synthase n=2 Tax=Alteromonadales R...   161   1e-38
UniRef50_Q26D11 Pseudouridine synthase n=2 Tax=Flavobacteria Rep...   161   2e-38
UniRef50_B7VRG6 Pseudouridine synthase n=4 Tax=Vibrionales RepID...   159   5e-38
UniRef50_C7PHX6 Pseudouridine synthase n=1 Tax=Chitinophaga pine...   159   7e-38
UniRef50_A6LDZ7 Pseudouridine synthase n=26 Tax=Bacteroidales Re...   158   1e-37
UniRef50_Q6AIJ2 Probable ribosomal large subunit pseudouridine s...   156   5e-37
UniRef50_A6TAT3 Pseudouridine synthase n=57 Tax=Bacteria RepID=A...   154   2e-36
UniRef50_C7QW59 Pseudouridine synthase n=5 Tax=Cyanobacteria Rep...   154   2e-36
UniRef50_D1PU24 Pseudouridine synthase n=1 Tax=Prevotella bergen...   154   2e-36
UniRef50_Q5E092 Pseudouridine synthase n=3 Tax=Aliivibrio RepID=...   154   2e-36
UniRef50_Q0F1Z5 Pseudouridine synthase n=1 Tax=Mariprofundus fer...   154   3e-36
UniRef50_Q1CZL9 Pseudouridine synthase n=5 Tax=Proteobacteria Re...   153   4e-36
UniRef50_B7BE87 Pseudouridine synthase n=8 Tax=Bacteroidales Rep...   152   8e-36
UniRef50_B1XN95 Pseudouridine synthase n=1 Tax=Synechococcus sp....   152   9e-36
UniRef50_A5WHV7 Pseudouridine synthase n=3 Tax=Psychrobacter Rep...   152   9e-36
UniRef50_D1PDP7 Pseudouridine synthase n=1 Tax=Prevotella copri ...   151   1e-35
UniRef50_C1AE05 Pseudouridine synthase n=1 Tax=Gemmatimonas aura...   148   1e-34
UniRef50_A5ZGG0 Pseudouridine synthase n=4 Tax=Bacteroides RepID...   148   1e-34
UniRef50_C5VJ38 Pseudouridine synthase n=2 Tax=Prevotella RepID=...   148   1e-34
UniRef50_D1W0M0 Pseudouridine synthase n=1 Tax=Prevotella timone...   145   7e-34
UniRef50_B2J8D4 Pseudouridine synthase n=7 Tax=Cyanobacteria Rep...   145   1e-33
UniRef50_D0P480 Ribosomal large subunit pseudouridine synthase A...   145   1e-33
UniRef50_C6BRU5 Pseudouridine synthase n=1 Tax=Desulfovibrio sal...   144   2e-33
UniRef50_B0JGC2 Pseudouridine synthase n=2 Tax=Microcystis aerug...   143   4e-33
UniRef50_Q31NG5 Pseudouridine synthase n=2 Tax=Synechococcus elo...   142   6e-33
UniRef50_B1ZYX0 Pseudouridine synthase n=4 Tax=Verrucomicrobia R...   140   3e-32
UniRef50_A6FXR5 Pseudouridine synthase n=1 Tax=Plesiocystis paci...   134   2e-30
UniRef50_D1QMM7 Pseudouridine synthase n=1 Tax=Prevotella oris F...   134   2e-30
UniRef50_B8J173 Pseudouridine synthase, RluA family n=2 Tax=Desu...   132   1e-29
UniRef50_C2HWY8 Pseudouridine synthase n=2 Tax=Vibrio cholerae R...   131   2e-29
UniRef50_D1XZI5 Pseudouridine synthase n=1 Tax=Prevotella bivia ...   127   3e-28
UniRef50_Q82WZ5 Ribosomal large subunit pseudouridine synthase D...   127   3e-28
UniRef50_C7LWM1 Pseudouridine synthase, RluA family n=1 Tax=Desu...   126   5e-28
UniRef50_B8CCD9 Predicted protein (Fragment) n=2 Tax=Thalassiosi...   126   6e-28
UniRef50_C4XSN0 Ribosomal large subunit pseudouridine synthase D...   125   7e-28
UniRef50_Q1MQ60 Pseudouridylate synthases, 23S RNA-specific n=1 ...   125   9e-28
UniRef50_UPI00016B2413 ribosomal large subunit pseudouridine syn...   125   1e-27
UniRef50_Q0BUM2 Pseudouridine synthase n=12 Tax=Acetobacteraceae...   125   1e-27
UniRef50_Q2RQY9 Pseudouridine synthase n=3 Tax=Alphaproteobacter...   124   2e-27
UniRef50_C1ZGS9 Pseudouridine synthase n=1 Tax=Planctomyces limn...   124   2e-27
UniRef50_B4UM41 Pseudouridine synthase, RluA family n=4 Tax=Anae...   123   4e-27
UniRef50_Q1ILA4 Pseudouridine synthase n=1 Tax=Candidatus Koriba...   122   1e-26
UniRef50_A6C0W7 Pseudouridine synthase n=1 Tax=Planctomyces mari...   122   1e-26
UniRef50_D0XS67 Pseudouridine synthase n=1 Tax=Brevundimonas sub...   122   1e-26
UniRef50_C0QAZ3 RluD1 n=1 Tax=Desulfobacterium autotrophicum HRM...   121   2e-26
UniRef50_Q9KQH0 Ribosomal large subunit pseudouridine synthase C...   121   2e-26
UniRef50_Q8ZQ16 Ribosomal large subunit pseudouridine synthase C...   121   2e-26
UniRef50_B2UL66 Pseudouridine synthase n=2 Tax=Verrucomicrobiace...   121   2e-26
UniRef50_Q1DCE5 Pseudouridine synthase, RluA family n=2 Tax=Cyst...   120   3e-26
UniRef50_C6J6E3 Pseudouridine synthase n=2 Tax=Bacillales RepID=...   120   3e-26
UniRef50_Q0IBH1 Pseudouridine synthase n=11 Tax=Cyanobacteria Re...   120   4e-26
UniRef50_B8CWM0 Pseudouridine synthase n=1 Tax=Halothermothrix o...   120   5e-26
UniRef50_Q8XYX8 Ribosomal large subunit pseudouridine synthase D...   119   6e-26
UniRef50_Q3ABZ7 Pseudouridine synthase n=2 Tax=Bacteria RepID=Q3...   119   7e-26
UniRef50_A0L9J0 Pseudouridine synthase n=1 Tax=Magnetococcus sp....   119   9e-26
UniRef50_C8NEP8 Pseudouridine synthase n=1 Tax=Granulicatella ad...   119   9e-26
UniRef50_B9Y836 Pseudouridine synthase n=3 Tax=Firmicutes RepID=...   119   1e-25
UniRef50_Q2W2D5 Pseudouridine synthase n=39 Tax=Bacteria RepID=Q...   119   1e-25
UniRef50_A7HM17 Pseudouridine synthase n=2 Tax=Thermotogaceae Re...   118   1e-25
UniRef50_A3ZV48 Pseudouridine synthase n=1 Tax=Blastopirellula m...   118   1e-25
UniRef50_Q057L6 Pseudouridine synthase n=1 Tax=Buchnera aphidico...   118   2e-25
UniRef50_A9NGF1 Pseudouridine synthase n=1 Tax=Acholeplasma laid...   118   2e-25
UniRef50_A6NQQ9 Pseudouridine synthase n=1 Tax=Bacteroides capil...   117   2e-25
UniRef50_B7G8W7 Predicted protein (Fragment) n=1 Tax=Phaeodactyl...   117   2e-25
UniRef50_C6BSG2 Pseudouridine synthase, RluA family n=1 Tax=Desu...   117   2e-25
UniRef50_Q2G4F0 Pseudouridine synthase n=12 Tax=Alphaproteobacte...   117   3e-25
UniRef50_B5Y592 Predicted protein (Fragment) n=1 Tax=Phaeodactyl...   117   3e-25
UniRef50_B8GX34 Pseudouridine synthase n=7 Tax=Caulobacteraceae ...   117   3e-25
UniRef50_A9BMW0 Pseudouridine synthase n=10 Tax=Comamonadaceae R...   117   3e-25
UniRef50_C7RM94 Pseudouridine synthase n=11 Tax=Proteobacteria R...   117   3e-25
UniRef50_D2BIX0 Pseudouridine synthase n=5 Tax=Dehalococcoides R...   116   5e-25
UniRef50_A9BFW4 Pseudouridine synthase n=8 Tax=Thermotogaceae Re...   116   5e-25
UniRef50_P70870 Ribosomal large subunit pseudouridine synthase D...   116   5e-25
UniRef50_D1PCC3 Pseudouridine synthase n=1 Tax=Prevotella copri ...   116   6e-25
UniRef50_A1URK8 Pseudouridine synthase n=2 Tax=Bartonella RepID=...   115   7e-25
UniRef50_C4FYR8 Pseudouridine synthase n=1 Tax=Abiotrophia defec...   115   8e-25
UniRef50_D1Y3Y9 Pseudouridine synthase n=1 Tax=Pyramidobacter pi...   115   8e-25
UniRef50_A1AW00 Pseudouridine synthase n=2 Tax=sulfur-oxidizing ...   115   8e-25
UniRef50_Q492Q1 Pseudouridine synthase n=2 Tax=Candidatus Blochm...   115   9e-25
UniRef50_B8BQ07 Predicted protein n=1 Tax=Thalassiosira pseudona...   115   9e-25
UniRef50_D0MK65 Pseudouridine synthase n=1 Tax=Rhodothermus mari...   115   1e-24
UniRef50_A3EQJ0 Pseudouridine synthase n=1 Tax=Leptospirillum ru...   115   1e-24
UniRef50_B5YAZ5 Pseudouridine synthase n=2 Tax=Dictyoglomus RepI...   115   1e-24
UniRef50_Q6AJM1 Pseudouridine synthase n=1 Tax=Desulfotalea psyc...   115   1e-24
UniRef50_B0T2G2 Pseudouridine synthase n=6 Tax=Caulobacteraceae ...   115   1e-24
UniRef50_P59838 Ribosomal large subunit pseudouridine synthase D...   114   2e-24
UniRef50_A6GP31 Pseudouridine synthase n=1 Tax=Limnobacter sp. M...   114   2e-24
UniRef50_C0Z877 Pseudouridine synthase n=1 Tax=Brevibacillus bre...   114   2e-24
UniRef50_B9L028 Pseudouridine synthase n=2 Tax=Thermomicrobia (c...   114   2e-24
UniRef50_Q89AH2 Ribosomal large subunit pseudouridine synthase C...   114   3e-24
UniRef50_A5EX53 Pseudouridine synthase n=1 Tax=Dichelobacter nod...   114   3e-24
UniRef50_A7HV45 Pseudouridine synthase n=56 Tax=Alphaproteobacte...   114   3e-24
UniRef50_D1BAB3 Pseudouridine synthase n=1 Tax=Thermanaerovibrio...   114   3e-24
UniRef50_Q0F3G4 Pseudouridine synthase n=1 Tax=Mariprofundus fer...   114   3e-24
UniRef50_A6DUC9 Pseudouridine synthase n=1 Tax=Lentisphaera aran...   114   3e-24
UniRef50_D2L0S2 Pseudouridine synthase, RluA family n=1 Tax=Desu...   113   4e-24
UniRef50_B6AN83 Pseudouridine synthase n=2 Tax=Leptospirillum Re...   113   4e-24
UniRef50_C6CWL6 Pseudouridine synthase n=2 Tax=Paenibacillus Rep...   113   4e-24
UniRef50_Q2LWV4 Pseudouridine synthase n=1 Tax=Syntrophus acidit...   113   4e-24
UniRef50_A6FJ39 Pseudouridine synthase n=1 Tax=Moritella sp. PE3...   113   5e-24
UniRef50_C9M5C8 Pseudouridine synthase n=1 Tax=Jonquetella anthr...   113   6e-24
UniRef50_A8ZXZ8 Pseudouridine synthase n=1 Tax=Desulfococcus ole...   112   6e-24
UniRef50_B6IQX5 Pseudouridine synthase n=1 Tax=Rhodospirillum ce...   112   6e-24
UniRef50_A5WFS2 Pseudouridine synthase n=3 Tax=Psychrobacter Rep...   112   7e-24
UniRef50_B7HGW1 Pseudouridine synthase n=52 Tax=Bacillales RepID...   112   9e-24
UniRef50_Q30SZ1 Pseudouridine synthase n=2 Tax=Proteobacteria Re...   112   9e-24
UniRef50_A4RT55 Predicted protein (Fragment) n=3 Tax=Chlorophyta...   112   1e-23
UniRef50_B9MS57 Pseudouridine synthase n=1 Tax=Anaerocellum ther...   112   1e-23
UniRef50_Q9JVB6 Ribosomal large subunit pseudouridine synthase D...   112   1e-23
UniRef50_C6WV38 Pseudouridine synthase n=3 Tax=Proteobacteria Re...   111   1e-23
UniRef50_Q1Q689 Similar to ribosomal large subunit pseudouridine...   111   2e-23
UniRef50_D0KVM5 Pseudouridine synthase n=11 Tax=Proteobacteria R...   110   3e-23
UniRef50_A9IQ66 Pseudouridine synthase n=5 Tax=Bacteria RepID=A9...   110   3e-23
UniRef50_P65834 Ribosomal large subunit pseudouridine synthase D...   110   3e-23
UniRef50_Q1RJX7 Ribosomal large subunit pseudouridine synthase C...   110   4e-23
UniRef50_Q28US1 Pseudouridine synthase n=43 Tax=Rhodobacterales ...   110   4e-23
UniRef50_C0ZCK6 Pseudouridine synthase n=1 Tax=Brevibacillus bre...   110   4e-23
UniRef50_D1RB31 Pseudouridine synthase n=1 Tax=Parachlamydia aca...   110   4e-23
UniRef50_A8MF48 Pseudouridine synthase n=12 Tax=Clostridiaceae R...   110   5e-23
UniRef50_C7GZW0 Pseudouridine synthase n=1 Tax=Eubacterium saphe...   110   5e-23
UniRef50_Q38VN9 Pseudouridine synthase n=1 Tax=Lactobacillus sak...   109   5e-23
UniRef50_D1N7N8 Pseudouridine synthase, RluA family n=1 Tax=Vict...   109   5e-23
UniRef50_P74346 Uncharacterized RNA pseudouridine synthase slr16...   109   6e-23
UniRef50_B8DF66 Pseudouridine synthase n=18 Tax=Listeria RepID=B...   109   7e-23
UniRef50_D2QJH0 Pseudouridine synthase, RluA family n=3 Tax=Bact...   109   7e-23
UniRef50_C7PP03 Pseudouridine synthase n=1 Tax=Chitinophaga pine...   109   7e-23
UniRef50_UPI0001C42CC7 hypothetical protein BpOF4_01845 n=1 Tax=...   109   8e-23
UniRef50_A4J1I1 Pseudouridine synthase n=1 Tax=Desulfotomaculum ...   109   8e-23
UniRef50_B7FU02 Predicted protein (Fragment) n=1 Tax=Phaeodactyl...   109   8e-23
UniRef50_B8FT16 Pseudouridine synthase n=70 Tax=Bacteria RepID=B...   108   9e-23
UniRef50_A0LPH5 Pseudouridine synthase n=1 Tax=Syntrophobacter f...   108   9e-23
UniRef50_C4FWV7 Pseudouridine synthase n=2 Tax=Firmicutes RepID=...   108   1e-22
UniRef50_D2R4N0 Pseudouridine synthase, RluA family n=1 Tax=Pire...   108   1e-22
UniRef50_A6SXT6 Pseudouridine synthase n=1 Tax=Janthinobacterium...   108   1e-22
UniRef50_Q0BYW5 Pseudouridine synthase family protein n=1 Tax=Hy...   108   1e-22
UniRef50_D1U4S9 Pseudouridine synthase, RluA family n=1 Tax=Desu...   108   1e-22
UniRef50_C1TRW2 Pseudouridine synthase n=1 Tax=Dethiosulfovibrio...   108   1e-22
UniRef50_P50513 Ribosomal large subunit pseudouridine synthase D...   108   1e-22
UniRef50_C8QZ10 Pseudouridine synthase n=1 Tax=Desulfurivibrio a...   108   2e-22
UniRef50_Q87AR7 Ribosomal large subunit pseudouridine synthase D...   107   2e-22
UniRef50_D0LUH1 Pseudouridine synthase n=1 Tax=Haliangium ochrac...   107   2e-22
UniRef50_Q83G23 Pseudouridine synthase n=2 Tax=Tropheryma whippl...   107   2e-22
UniRef50_Q38Y05 Pseudouridine synthase, 23S-rRNA-specific n=1 Ta...   107   2e-22
UniRef50_A0LBW6 Pseudouridine synthase n=1 Tax=Magnetococcus sp....   107   2e-22
UniRef50_Q5PAD0 Pseudouridine synthase n=5 Tax=Anaplasma RepID=Q...   107   2e-22
UniRef50_Q211J3 Pseudouridine synthase n=81 Tax=Alphaproteobacte...   107   2e-22
UniRef50_A9B3Z2 Pseudouridine synthase n=1 Tax=Herpetosiphon aur...   107   3e-22
UniRef50_Q312A0 Pseudouridine synthase, RluD n=6 Tax=Bacteria Re...   107   3e-22
UniRef50_B5YKV0 Pseudouridine synthase n=1 Tax=Thermodesulfovibr...   107   3e-22
UniRef50_B5JHH9 Pseudouridine synthase n=1 Tax=Verrucomicrobiae ...   107   3e-22
UniRef50_Q8ZFU1 Ribosomal large subunit pseudouridine synthase C...   107   3e-22
UniRef50_D1Y726 Ribosomal large subunit pseudouridine synthase D...   107   3e-22
UniRef50_Q47417 tRNA pseudouridine synthase C n=252 Tax=cellular...   107   3e-22
UniRef50_C7LR44 Pseudouridine synthase n=6 Tax=Bacteria RepID=C7...   107   3e-22
UniRef50_O31613 Uncharacterized RNA pseudouridine synthase yjbO ...   107   4e-22
UniRef50_Q5QZ45 Pseudouridine synthase n=2 Tax=Gammaproteobacter...   107   4e-22
UniRef50_C9KPZ8 Pseudouridine synthase n=1 Tax=Mitsuokella multa...   107   4e-22
UniRef50_D1RB93 Pseudouridine synthase n=1 Tax=Parachlamydia aca...   107   4e-22
UniRef50_C8PW17 Pseudouridine synthase n=5 Tax=Moraxellaceae Rep...   107   4e-22
UniRef50_B8FLB4 Pseudouridine synthase n=2 Tax=Bacteria RepID=B8...   107   4e-22
UniRef50_Q5Z213 Pseudouridine synthase n=2 Tax=Actinomycetales R...   106   5e-22
UniRef50_C6VIZ5 Pseudouridine synthase n=3 Tax=Lactobacillus pla...   106   5e-22
UniRef50_C9RQF0 Pseudouridine synthase, RluA family n=1 Tax=Fibr...   106   5e-22
UniRef50_C0GNZ6 Pseudouridine synthase, RluA family n=1 Tax=Desu...   106   6e-22
UniRef50_C8WW59 Pseudouridine synthase n=2 Tax=Alicyclobacillus ...   106   6e-22
UniRef50_B1ZRU1 Pseudouridine synthase n=2 Tax=Opitutaceae RepID...   106   7e-22
UniRef50_C8PQT2 Ribosomal large subunit pseudouridine synthase D...   106   7e-22
UniRef50_B2KBB0 Pseudouridine synthase n=1 Tax=Elusimicrobium mi...   105   7e-22
UniRef50_A3VN52 Ribosomal large subunit pseudouridine synthase C...   105   8e-22
UniRef50_A4XKV9 Pseudouridine synthase n=1 Tax=Caldicellulosirup...   105   8e-22
UniRef50_O50310 Uncharacterized RNA pseudouridine synthase Cpar_...   105   8e-22
UniRef50_C1A885 Pseudouridine synthase n=1 Tax=Gemmatimonas aura...   105   9e-22
UniRef50_A6G930 Pseudouridine synthase n=1 Tax=Plesiocystis paci...   105   9e-22
UniRef50_A1K5H7 Pseudouridine synthase n=5 Tax=Proteobacteria Re...   105   9e-22
UniRef50_B1I3F8 Pseudouridine synthase n=2 Tax=Bacteria RepID=B1...   105   9e-22
UniRef50_C0MA80 Pseudouridine synthase n=6 Tax=Streptococcus Rep...   105   9e-22
UniRef50_B1H073 Ribosomal large subunit pseudouridine synthase C...   105   9e-22
UniRef50_A4FXG9 Pseudouridine synthase, RluA family n=5 Tax=Meth...   105   1e-21
UniRef50_B9DS29 Pseudouridine synthase n=85 Tax=Firmicutes RepID...   105   1e-21
UniRef50_B9JWI8 Pseudouridine synthase n=1 Tax=Agrobacterium vit...   105   1e-21
UniRef50_B7P2L1 Ribosomal pseudouridine synthase, putative n=1 T...   105   1e-21
UniRef50_D1CBT6 Pseudouridine synthase n=1 Tax=Thermobaculum ter...   105   1e-21
UniRef50_B8CWB7 Pseudouridine synthase n=1 Tax=Halothermothrix o...   105   1e-21
UniRef50_C1FEQ4 Predicted protein n=2 Tax=Micromonas RepID=C1FEQ...   105   1e-21
UniRef50_D2R760 Pseudouridine synthase, RluA family n=2 Tax=Plan...   105   1e-21
UniRef50_Q4FN11 Pseudouridine synthase n=4 Tax=Bacteria RepID=Q4...   105   1e-21
UniRef50_C1E6N6 Pseudouridine synthase n=2 Tax=Micromonas RepID=...   105   1e-21
UniRef50_C6XFD0 Pseudouridine synthase n=1 Tax=Candidatus Liberi...   105   1e-21
UniRef50_C8W9Q3 Pseudouridine synthase n=2 Tax=Atopobium RepID=C...   105   1e-21
UniRef50_C9LM35 Pseudouridine synthase n=1 Tax=Dialister invisus...   105   1e-21
UniRef50_Q1J0S8 Pseudouridine synthase n=7 Tax=Deinococci RepID=...   105   1e-21
UniRef50_C6VVP1 Pseudouridine synthase n=4 Tax=Bacteroidetes Rep...   105   2e-21
UniRef50_B2A2J2 Pseudouridine synthase n=1 Tax=Natranaerobius th...   104   2e-21
UniRef50_D0MJ49 Pseudouridine synthase n=2 Tax=Bacteria RepID=D0...   104   2e-21
UniRef50_C6VN18 Pseudouridine synthase n=3 Tax=Lactobacillus pla...   104   2e-21
UniRef50_P0A5T2 Uncharacterized RNA pseudouridine synthase Rv154...   104   2e-21
UniRef50_A8IAL9 Pseudouridine synthase n=2 Tax=Xanthobacteraceae...   104   2e-21
UniRef50_A3I3R5 Ribosomal large subunit pseudouridine synthase n...   104   2e-21
UniRef50_C9KIU1 Pseudouridine synthase n=3 Tax=Veillonellaceae R...   104   2e-21
UniRef50_Q2SS88 Pseudouridine synthase n=4 Tax=Mollicutes RepID=...   104   2e-21
UniRef50_C8P137 Pseudouridine synthase n=1 Tax=Erysipelothrix rh...   104   2e-21
UniRef50_D0LU78 Pseudouridine synthase n=1 Tax=Haliangium ochrac...   104   2e-21
UniRef50_B9XHZ1 Pseudouridine synthase, RluA family n=2 Tax=Verr...   104   3e-21
UniRef50_C1CWT3 Pseudouridine synthase n=1 Tax=Deinococcus deser...   104   3e-21
UniRef50_C0QPR5 Pseudouridine synthase n=4 Tax=Hydrogenothermace...   104   3e-21
UniRef50_Q0F3G2 Possible pseudouridine synthase n=1 Tax=Mariprof...   103   3e-21
UniRef50_B9XS18 Pseudouridine synthase n=1 Tax=bacterium Ellin51...   103   3e-21
UniRef50_Q1AVY4 Pseudouridine synthase n=2 Tax=Rubrobacteridae R...   103   3e-21
UniRef50_C8X1I9 Pseudouridine synthase, RluA family n=1 Tax=Desu...   103   3e-21
UniRef50_Q1WS68 Pseudouridine synthase n=2 Tax=Lactobacillus sal...   103   3e-21
UniRef50_A4CVN5 Pseudouridine synthase n=1 Tax=Synechococcus sp....   103   3e-21
UniRef50_UPI000178A5E6 pseudouridine synthase, RluA family n=1 T...   103   3e-21
UniRef50_A7NB61 Pseudouridine synthase n=18 Tax=Francisella RepI...   103   4e-21
UniRef50_Q1VZ16 Pseudouridine synthase n=1 Tax=Psychroflexus tor...   103   4e-21
UniRef50_B8I750 Pseudouridine synthase, RluA family n=2 Tax=Clos...   103   4e-21
UniRef50_Q6MEC0 Pseudouridine synthase n=1 Tax=Candidatus Protoc...   103   4e-21
UniRef50_C7LZI3 Pseudouridine synthase n=1 Tax=Acidimicrobium fe...   103   5e-21
UniRef50_Q7UHX8 Pseudouridine synthase n=1 Tax=Rhodopirellula ba...   103   5e-21
UniRef50_C7TK72 Ribosomal large subunit 23S pseudouridine syntha...   103   5e-21
UniRef50_C0BNA6 Pseudouridine synthase n=7 Tax=Bacteroidetes Rep...   103   5e-21
UniRef50_Q45826 Uncharacterized RNA pseudouridine synthase Caur_...   103   5e-21
UniRef50_A6TSZ4 Pseudouridine synthase n=1 Tax=Alkaliphilus meta...   102   6e-21
UniRef50_B1H0R5 Pseudouridine synthase n=1 Tax=uncultured Termit...   102   6e-21

>UniRef50_P0AA37 Ribosomal large subunit pseudouridine synthase A n=205
           Tax=Proteobacteria RepID=RLUA_ECOLI
          Length = 219

 Score =  456 bits (1173), Expect = e-127,   Method: Compositional matrix adjust.
 Identities = 219/219 (100%), Positives = 219/219 (100%)

Query: 1   MGMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESV 60
           MGMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESV
Sbjct: 1   MGMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESV 60

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP
Sbjct: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120

Query: 121 NRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRF 180
           NRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRF
Sbjct: 121 NRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRF 180

Query: 181 YASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
           YASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF
Sbjct: 181 YASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219


>UniRef50_A3MZ33 Pseudouridine synthase n=9 Tax=Proteobacteria RepID=A3MZ33_ACTP2
          Length = 237

 Score =  290 bits (741), Expect = 3e-77,   Method: Compositional matrix adjust.
 Identities = 136/222 (61%), Positives = 170/222 (76%), Gaps = 3/222 (1%)

Query: 1   MGMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESV 60
           M +  Y+PP EP+L  +Y+D+HI+V+NKPSGLLSVPG   E+ DS MTR+Q+ Y   E  
Sbjct: 16  MALIEYHPPLEPFLTEVYRDNHILVINKPSGLLSVPGNRPEYYDSAMTRVQQKYGFTEPA 75

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPA---EGLVDLPLIC 117
           HRLDMATSG+++ AL+KAAE+ELKRQFR+REPKK Y+A +WG         G ++ PLIC
Sbjct: 76  HRLDMATSGILLFALSKAAEKELKRQFRDREPKKHYIALLWGKLGEKVGDTGEMNFPLIC 135

Query: 118 DWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILG 177
           DW NRP+QK+CYE GK A T YEV+ +  +NT RV L PITGRSHQLRVH LALGHPILG
Sbjct: 136 DWENRPRQKICYERGKKAITHYEVLAHLPNNTTRVKLTPITGRSHQLRVHSLALGHPILG 195

Query: 178 DRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
           D+FYASP A++++PRL LHAE L+ITHP  G +MTF A  +F
Sbjct: 196 DKFYASPLAKSLSPRLCLHAESLSITHPITGEAMTFTAQTEF 237


>UniRef50_P59831 Ribosomal large subunit pseudouridine synthase A n=20
           Tax=Proteobacteria RepID=RLUA_HAEDU
          Length = 222

 Score =  284 bits (727), Expect = 1e-75,   Method: Compositional matrix adjust.
 Identities = 135/222 (60%), Positives = 167/222 (75%), Gaps = 3/222 (1%)

Query: 1   MGMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESV 60
           M +  Y+PP  P+L  +Y+D+HI+V+NKPSGLLSVPG   E+ DSVMTR+Q+ Y  AE  
Sbjct: 1   MALIEYHPPLNPFLEEVYRDNHIVVINKPSGLLSVPGNRPEYYDSVMTRVQQRYGFAEPA 60

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSP---AEGLVDLPLIC 117
           HRLDMATSG+I++AL+K AE+ELKRQFR+REPKK Y+A +WG         G ++ PLIC
Sbjct: 61  HRLDMATSGIILLALSKVAEKELKRQFRDREPKKHYIALLWGKLGDRVGQTGEINFPLIC 120

Query: 118 DWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILG 177
           DW NRP+QK+CYE GK A T YEV+E+ A+NT RV   PITGRSHQLRVH LALGHPI+G
Sbjct: 121 DWENRPRQKICYERGKKATTHYEVLEHLANNTTRVKFTPITGRSHQLRVHSLALGHPIIG 180

Query: 178 DRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
           D+FYA+P A+++APRL LHAE LTI HP     MTF     F
Sbjct: 181 DKFYANPLAKSLAPRLCLHAESLTIAHPISAELMTFNTEPTF 222


>UniRef50_B8K915 Pseudouridine synthase n=5 Tax=Vibrio RepID=B8K915_VIBPA
          Length = 254

 Score =  257 bits (656), Expect = 2e-67,   Method: Compositional matrix adjust.
 Identities = 125/219 (57%), Positives = 157/219 (71%), Gaps = 1/219 (0%)

Query: 1   MGMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESV 60
           M M  YNPP+EPW+ I+++D+HI+V NKPSGLLSVPGRLEEH DS+ +R+   YP  + V
Sbjct: 10  MAMTEYNPPREPWVDIVFEDEHILVANKPSGLLSVPGRLEEHYDSLWSRLVAIYPDIQVV 69

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLDM TSG++++A  K AER LK+QF+ R   K Y ARVWGHP+   G +DLPLICDWP
Sbjct: 70  HRLDMDTSGLMLLAKHKEAERSLKKQFQYRLTHKVYYARVWGHPTNDNGEIDLPLICDWP 129

Query: 121 NRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRF 180
           NRP+Q VC++ GKP++T Y+VV+   + T+ V L PITGRSHQLRVHM ALGHPI+GD F
Sbjct: 130 NRPRQIVCFDDGKPSKTLYQVVK-REERTSIVRLLPITGRSHQLRVHMQALGHPIVGDEF 188

Query: 181 YASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
           Y+  EA   + RL LHA  L+  HP          P DF
Sbjct: 189 YSEGEAFEFSDRLELHAAELSFYHPHSEALQCAFVPCDF 227


>UniRef50_A7K2Y9 Pseudouridine synthase n=4 Tax=Vibrio RepID=A7K2Y9_VIBSE
          Length = 250

 Score =  256 bits (655), Expect = 3e-67,   Method: Compositional matrix adjust.
 Identities = 122/223 (54%), Positives = 161/223 (72%), Gaps = 4/223 (1%)

Query: 1   MGMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESV 60
           M M  Y PP +PW+ I+++DD I+ VNKPSGLLSVPGRL EH DS+ +R++  +P+ + V
Sbjct: 1   MAMLEYTPPTDPWVDIVFEDDDILAVNKPSGLLSVPGRLAEHYDSMWSRLKEVHPEIQVV 60

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLDM+TSG++++A  K +ER LK+QF+ R   K Y ARVWGH  P EG +DLPLICDWP
Sbjct: 61  HRLDMSTSGLMLLAKNKPSERALKKQFQYRLTHKVYYARVWGHVEPQEGNIDLPLICDWP 120

Query: 121 NRPKQKVCYETGKPAQTEYEVV--EYAADNTARVVLK--PITGRSHQLRVHMLALGHPIL 176
           NRP+QKVC++ GKP+QT ++VV  E  +D T   V++  PITGRSHQLRVH++A+GH I+
Sbjct: 121 NRPRQKVCFDDGKPSQTLFQVVKREVHSDGTHTTVVRLLPITGRSHQLRVHLMAIGHAIV 180

Query: 177 GDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
           GD FYA+ EA   + RL LHA  L+  HPA     +   P DF
Sbjct: 181 GDEFYATEEAYQFSERLELHAAELSFYHPATDQLSSIFVPCDF 223


>UniRef50_Q8DCG0 Ribosomal large subunit pseudouridine synthase A n=82
           Tax=Proteobacteria RepID=RLUA_VIBVU
          Length = 250

 Score =  252 bits (643), Expect = 8e-66,   Method: Compositional matrix adjust.
 Identities = 122/223 (54%), Positives = 153/223 (68%), Gaps = 4/223 (1%)

Query: 1   MGMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESV 60
           M M  Y PP +PW  I+++DDHI+ VNKPSGLLSVPGRL EH DS+ +R+Q  YP+ + V
Sbjct: 1   MAMLEYLPPTDPWTEIIFEDDHILAVNKPSGLLSVPGRLPEHHDSMWSRLQEQYPEIQVV 60

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLDM+TSG++V A  K AE  LK+QF+ R   K Y ARVWGH     G++DLPLICDWP
Sbjct: 61  HRLDMSTSGLMVFAKNKRAEAALKKQFQYRLTHKVYYARVWGHVEADSGMIDLPLICDWP 120

Query: 121 NRPKQKVCYETGKPAQTEYEVV--EYAADNTARVVLK--PITGRSHQLRVHMLALGHPIL 176
           NRP QKVC+E GKP+QT ++V   E  A+     +++  P+TGRSHQLRVHM ALGHPI+
Sbjct: 121 NRPMQKVCHEHGKPSQTAFQVAKREVHANGAQTTIMRLLPVTGRSHQLRVHMQALGHPIV 180

Query: 177 GDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
           GD FYA  +A   + RL LHA  L+  HP      +   P DF
Sbjct: 181 GDEFYAQGDAFTFSERLELHAAELSFYHPKSHWLRSLFVPCDF 223


>UniRef50_C7LVL1 Pseudouridine synthase n=5 Tax=Proteobacteria RepID=C7LVL1_DESBD
          Length = 234

 Score =  233 bits (593), Expect = 5e-60,   Method: Compositional matrix adjust.
 Identities = 120/214 (56%), Positives = 154/214 (71%), Gaps = 4/214 (1%)

Query: 6   YNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDM 65
           Y+PP EP L ++++D  ++VVNKPSGLLSVPGR  E  DSV++R++  +  A++VHRLD+
Sbjct: 8   YDPPTEPRLAVIHEDRDMVVVNKPSGLLSVPGRTPELFDSVLSRVREIHRGAQAVHRLDL 67

Query: 66  ATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQ 125
            TSGV+VVA  + AE  L++QF++R  +K Y+ARV G  S   G VDLPLICDWPNRP Q
Sbjct: 68  GTSGVLVVATRRKAETILRQQFQDRLTRKLYLARVQGVMSEDSGQVDLPLICDWPNRPMQ 127

Query: 126 KVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPE 185
            VC++TGKPA T+Y+V+E   ++T  V+L+P TGRSHQLRVHM +LGHPILGD  Y   E
Sbjct: 128 MVCHDTGKPALTDYQVLESDGESTL-VLLRPHTGRSHQLRVHMASLGHPILGDNLYG--E 184

Query: 186 ARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
            R    RLLLHA  L + HP  G   TF AP DF
Sbjct: 185 QRP-GERLLLHASQLGLYHPYSGEWTTFHAPCDF 217


>UniRef50_Q28K21 Pseudouridine synthase n=11 Tax=Proteobacteria RepID=Q28K21_JANSC
          Length = 217

 Score =  225 bits (573), Expect = 1e-57,   Method: Compositional matrix adjust.
 Identities = 118/214 (55%), Positives = 149/214 (69%), Gaps = 3/214 (1%)

Query: 6   YNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDM 65
           Y PP +P L I+++D  +++VNKP+GLLSVPG+ E   D ++ R++  +P+   VHRLDM
Sbjct: 7   YAPPTDP-LDIIHEDHDLLLVNKPAGLLSVPGKGEHLSDCLIARLKIAFPEVLLVHRLDM 65

Query: 66  ATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQ 125
            TSGV+V A T  A+R L  QF +R  KK YVARVWG  +  +G +DLPLI DWPNRP Q
Sbjct: 66  DTSGVMVFARTPHAQRHLGLQFEKRHTKKAYVARVWGEVTDKDGHIDLPLIVDWPNRPLQ 125

Query: 126 KVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPE 185
            V +ETGKPAQT++  +    D T R+ L P TGRSHQLRVHMLA+GHPILGD FYA+  
Sbjct: 126 HVNHETGKPAQTDWRRIR-VEDGTTRMRLFPKTGRSHQLRVHMLAIGHPILGDPFYATGP 184

Query: 186 ARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
           A A  PRL+LHAE L + HP  G  MTF+A   F
Sbjct: 185 ALAF-PRLMLHAESLKLRHPDGGIGMTFRARVPF 217


>UniRef50_Q2CAH0 Pseudouridine synthase n=3 Tax=Proteobacteria RepID=Q2CAH0_9RHOB
          Length = 215

 Score =  223 bits (569), Expect = 2e-57,   Method: Compositional matrix adjust.
 Identities = 119/216 (55%), Positives = 148/216 (68%), Gaps = 3/216 (1%)

Query: 4   ENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRL 63
            +Y+PP  P L +L++D  +++V+KP+GLLSVPG+ E   D ++ R+Q  +P A  VHRL
Sbjct: 3   SDYDPPDVP-LAVLHEDHEVVLVDKPAGLLSVPGKGEHLADCLLARVQAAFPTALLVHRL 61

Query: 64  DMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRP 123
           D  TSGV++ ALT  A+R L  QF +R+ +K YVARV G  +   G VDLPLI DWPNRP
Sbjct: 62  DRDTSGVMIFALTPHAQRHLGLQFEKRQTRKTYVARVAGRIADKTGTVDLPLIVDWPNRP 121

Query: 124 KQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYAS 183
           KQ V +E GKPA T++ VV  A+D   RV L P TGRSHQLRVHMLALGHPILGD FYA 
Sbjct: 122 KQMVDHENGKPAVTDWRVVR-ASDAETRVRLFPKTGRSHQLRVHMLALGHPILGDPFYAE 180

Query: 184 PEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
             ARA  PR++LH+E L   HP  G  M   APA F
Sbjct: 181 GPARAH-PRMMLHSETLQFRHPDGGRGMRITAPAPF 215


>UniRef50_A9CFZ5 Pseudouridine synthase n=3 Tax=Rhizobiales RepID=A9CFZ5_AGRT5
          Length = 222

 Score =  221 bits (564), Expect = 1e-56,   Method: Compositional matrix adjust.
 Identities = 108/214 (50%), Positives = 148/214 (69%), Gaps = 1/214 (0%)

Query: 6   YNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDM 65
           YNPP +PWL I+++DD ++V++KPSGLLSVPGR     DS+MTR+Q+ +P+A  ++RLD 
Sbjct: 10  YNPPLDPWLTIVHRDDDLLVLDKPSGLLSVPGRDPALSDSLMTRVQKQFPKALMINRLDK 69

Query: 66  ATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQ 125
            TSG+++++L + A   +  QF +RE +K YVA VWG  +  EG VDLPL  D  N+P+ 
Sbjct: 70  DTSGIVLMSLNRKAHAAIAAQFEKRETRKSYVAIVWGTVAGEEGEVDLPLAIDPDNKPRH 129

Query: 126 KVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPE 185
           +V +E GKPAQ+ + V+E       R+ L P+TGR+HQLRVHM ALGHPILGD FYA  E
Sbjct: 130 RVDHENGKPAQSLWRVLERLPLPATRLALTPLTGRTHQLRVHMKALGHPILGDEFYAEGE 189

Query: 186 ARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
           A   APRL+LHA+ +   HP  G  +T+  P  F
Sbjct: 190 ALTAAPRLMLHAQEVGFRHPD-GRDVTYTVPCPF 222


>UniRef50_A0YGE0 Pseudouridine synthase n=1 Tax=marine gamma proteobacterium
           HTCC2143 RepID=A0YGE0_9GAMM
          Length = 221

 Score =  210 bits (535), Expect = 2e-53,   Method: Compositional matrix adjust.
 Identities = 105/196 (53%), Positives = 134/196 (68%)

Query: 16  ILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDMATSGVIVVAL 75
           IL+ DD +++VNKP+GLLSVPGR   +KD ++TR+QR Y  A  VHRLDM TSG++V+AL
Sbjct: 17  ILFTDDDLLLVNKPAGLLSVPGRHPANKDCLITRVQRQYADARIVHRLDMDTSGIMVLAL 76

Query: 76  TKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYETGKPA 135
           +  + R L + F ER+  K+Y A V+G       L+DLPL+CDWPNRP+QKV +  GK A
Sbjct: 77  SADSHRALSQLFAERKIIKEYEANVYGTIIDDHRLIDLPLLCDWPNRPRQKVDFHHGKNA 136

Query: 136 QTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARAMAPRLLL 195
           QT  E V    D   RV+LKP+TGRSHQLRVH+  +GHPILG  FYA   A +MA RL L
Sbjct: 137 QTWVERVSQHPDGWTRVLLKPVTGRSHQLRVHLAEIGHPILGCEFYAHQRAVSMADRLQL 196

Query: 196 HAEMLTITHPAYGNSM 211
           HA  L   HP  G ++
Sbjct: 197 HATKLEFCHPNSGETI 212


>UniRef50_B1Y046 Pseudouridine synthase n=43 Tax=Proteobacteria RepID=B1Y046_LEPCP
          Length = 256

 Score =  208 bits (529), Expect = 1e-52,   Method: Compositional matrix adjust.
 Identities = 111/218 (50%), Positives = 137/218 (62%), Gaps = 7/218 (3%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDMATS 68
           P EP + IL+ DD ++VV KP+GLLSVPGR E  +D V  R+Q  +P A  VHRLDMATS
Sbjct: 39  PSEPLIDILHHDDSLLVVRKPAGLLSVPGRGEHLQDCVAARVQAIWPDALIVHRLDMATS 98

Query: 69  GVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVC 128
           G++V+A   AA+R L   F  R   KQYVA V G  +   G VDLPL  DWPNRP+QKV 
Sbjct: 99  GLMVMARGPAAQRALGSAFEHRSVTKQYVAVVAGDVAGDAGSVDLPLCADWPNRPRQKVD 158

Query: 129 YETGKPAQTEYEVVEYAADNT-------ARVVLKPITGRSHQLRVHMLALGHPILGDRFY 181
              G+P+ T +     A + +        R+ L+P+TGRSHQLRVH+LALGHPILGD  Y
Sbjct: 159 AAMGRPSLTHWRRATPAHEGSTTGDIDRTRLELEPVTGRSHQLRVHLLALGHPILGDTLY 218

Query: 182 ASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
           A    + MAPRLLLHA  + + HPA G    F  P  F
Sbjct: 219 APDAVQRMAPRLLLHASRIALPHPAGGGICVFSDPPAF 256


>UniRef50_Q0VQA6 Pseudouridine synthase n=7 Tax=Gammaproteobacteria
           RepID=Q0VQA6_ALCBS
          Length = 229

 Score =  206 bits (523), Expect = 6e-52,   Method: Compositional matrix adjust.
 Identities = 104/204 (50%), Positives = 133/204 (65%), Gaps = 1/204 (0%)

Query: 17  LYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDMATSGVIVVALT 76
           +Y+D+H++++NKP+ LLSVPGR  E+KD  + R+Q+ YP    VHRLD+ TSG++V  LT
Sbjct: 26  IYRDEHLLLINKPAYLLSVPGRAPENKDCAIRRLQQRYPDIRLVHRLDLDTSGIMVFGLT 85

Query: 77  KAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYETGKPAQ 136
             A+ +L R F+ R  KK+Y A V G      G +DLPLI DWP RP QKVC+ETGK A 
Sbjct: 86  AFAQSKLSRLFQLRTVKKRYQAIVHGLVEKNAGSIDLPLIADWPKRPLQKVCHETGKNAL 145

Query: 137 TEYEVVEY-AADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARAMAPRLLL 195
           T Y V+E     N  R+ L P+TGRSHQLR+H   LGHPI+G   YA  E  A++PRLLL
Sbjct: 146 THYRVLERDIPGNRTRLALSPVTGRSHQLRIHCRELGHPIIGCDMYAPAEIEALSPRLLL 205

Query: 196 HAEMLTITHPAYGNSMTFKAPADF 219
           HAE L   HP  G    F +P  F
Sbjct: 206 HAEWLAFNHPLTGLWQEFTSPCPF 229


>UniRef50_A4VJG2 Pseudouridine synthase n=18 Tax=Bacteria RepID=A4VJG2_PSEU5
          Length = 244

 Score =  206 bits (523), Expect = 6e-52,   Method: Compositional matrix adjust.
 Identities = 106/205 (51%), Positives = 141/205 (68%), Gaps = 2/205 (0%)

Query: 16  ILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRD-YPQAESVHRLDMATSGVIVVA 74
           I++QD  ++V++KP+ LLSVPGR E+++D ++TR+Q + YP+A  VHRLD  TSG+IV+A
Sbjct: 41  IVHQDAALLVIDKPTLLLSVPGRAEDNRDCLVTRLQENGYPEARIVHRLDWETSGLIVLA 100

Query: 75  LTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYETGKP 134
               + REL RQF +RE +K Y A  WG P    G +DLPL  D P +P+  V  E GK 
Sbjct: 101 RDADSHRELSRQFHDRETEKAYTALCWGQPDADSGSIDLPLRYDPPTKPRHVVDPELGKH 160

Query: 135 AQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARAMAPRLL 194
           A T + V+E   D++ RV L PITGRSHQLRVHML++GHP+LGDR YA  +A     RL 
Sbjct: 161 ALTFWRVLERCGDHS-RVELTPITGRSHQLRVHMLSIGHPLLGDRLYAHEQALRAHERLC 219

Query: 195 LHAEMLTITHPAYGNSMTFKAPADF 219
           LHA MLT+THP  G  + F++PA F
Sbjct: 220 LHASMLTLTHPQTGARLRFESPAPF 244


>UniRef50_Q31HX2 Pseudouridine synthase n=1 Tax=Thiomicrospira crunogena XCL-2
           RepID=Q31HX2_THICR
          Length = 241

 Score =  200 bits (508), Expect = 3e-50,   Method: Compositional matrix adjust.
 Identities = 100/212 (47%), Positives = 140/212 (66%), Gaps = 3/212 (1%)

Query: 8   PPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDMAT 67
           P Q  W  +LY+DD I+VVNKP+GLLSVPG+  + + +++ ++Q+  P A  VHRLDM T
Sbjct: 23  PFQLDW--VLYEDDDIIVVNKPAGLLSVPGKDLDPEMNLLAQVQKHVPTALIVHRLDMDT 80

Query: 68  SGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKV 127
           SG++++A  KA+ R L  QF++R  +K Y A  +G PS ++G ++LP+ CDW NRP Q +
Sbjct: 81  SGIMILAKHKASHRHLSIQFQDRLTEKTYQAICFGKPSTSQGHLNLPMRCDWENRPLQII 140

Query: 128 CYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEAR 187
             + GK A T +++     DN   V L P+TGRSHQLR+HM  LGHPILGD  YA P++ 
Sbjct: 141 DLKQGKAASTHWKLTA-QYDNAFEVNLTPVTGRSHQLRLHMKMLGHPILGDNLYADPQSF 199

Query: 188 AMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
           A + RLLLHA  L +THP    +M F+ P   
Sbjct: 200 AASKRLLLHAASLKVTHPVTKKTMLFEHPTSL 231


>UniRef50_Q12L72 Pseudouridine synthase n=17 Tax=Shewanella RepID=Q12L72_SHEDO
          Length = 230

 Score =  191 bits (484), Expect = 2e-47,   Method: Compositional matrix adjust.
 Identities = 105/205 (51%), Positives = 133/205 (64%), Gaps = 2/205 (0%)

Query: 1   MGMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESV 60
           M + NY PP  PWL I Y D  I+V+NKPSGLLS PGR  E  D+ +TR+QR YP+   +
Sbjct: 14  MQVFNYQPPSIPWLDIRYLDRDIIVINKPSGLLSNPGRAPETYDTAITRLQRLYPETILI 73

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLD  TSG+++ A  K AE  LK QF+ R+ KK Y+A V G     +G V+ PL  D  
Sbjct: 74  HRLDCDTSGIMIFARNKKAESNLKTQFQNRQAKKVYIAEVSGCFEHQDGKVNFPLGPDPM 133

Query: 121 NRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRF 180
             P Q+V  E+GKPA T Y ++E+ A +T+ V LKP TGR+HQLRVHM ALGH I+GD F
Sbjct: 134 TPPFQQVI-ESGKPALTYYRLLEHRA-STSLVELKPHTGRTHQLRVHMKALGHTIIGDEF 191

Query: 181 YASPEARAMAPRLLLHAEMLTITHP 205
           Y      A + RL LHA+ LT+ HP
Sbjct: 192 YGDETVIAASHRLNLHAQSLTLLHP 216


>UniRef50_C5BU65 Pseudouridine synthase for 23S rRNA and tRNAphe n=1
           Tax=Teredinibacter turnerae T7901 RepID=C5BU65_TERTT
          Length = 208

 Score =  191 bits (484), Expect = 2e-47,   Method: Compositional matrix adjust.
 Identities = 100/207 (48%), Positives = 126/207 (60%), Gaps = 3/207 (1%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDMATSGVIVV 73
           L I+YQDDHI+ +NKP+GLL+VPG      D+   ++   +P +  VHRLDMATSG+++ 
Sbjct: 4   LAIIYQDDHIIAINKPAGLLTVPGLAT--PDNAFDQLVHQHPNSRVVHRLDMATSGLVIF 61

Query: 74  ALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYETGK 133
             +  +     R F +R+  K Y A V G  +   G + LPLICDWPNRPKQKV  E GK
Sbjct: 62  PQSHESLVRFGRLFEQRKMTKTYTATVAGIVAEDRGEITLPLICDWPNRPKQKVDLEQGK 121

Query: 134 PAQTEYEVVEYAAD-NTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARAMAPR 192
            A T+Y+V+E   D  T R+ L PITGRSHQLRVHM  LGHPILGD FYA    +  + R
Sbjct: 122 HAHTQYKVLERRLDLQTTRIELTPITGRSHQLRVHMQQLGHPILGDAFYAPDAIQQASDR 181

Query: 193 LLLHAEMLTITHPAYGNSMTFKAPADF 219
           LLLHA  L   HP      +     DF
Sbjct: 182 LLLHATTLEFVHPFTQCPTSIHCEPDF 208


>UniRef50_Q489H0 Pseudouridine synthase n=3 Tax=Gammaproteobacteria
           RepID=Q489H0_COLP3
          Length = 567

 Score =  187 bits (476), Expect = 2e-46,   Method: Compositional matrix adjust.
 Identities = 101/219 (46%), Positives = 142/219 (64%), Gaps = 14/219 (6%)

Query: 7   NPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES---VHRL 63
           NP +   L I++QD+H++VVNKP+GLLSVPG+    KDSV TRI+  +PQA     VHRL
Sbjct: 357 NPAEGIDLEIVFQDEHVVVVNKPAGLLSVPGK--SIKDSVYTRIKTQFPQASGGLIVHRL 414

Query: 64  DMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRP 123
           DMATSG++++AL + A + L++QF  +E  K+YVA + G      G + LPL  D+ +RP
Sbjct: 415 DMATSGLLMLALNERAHKHLQQQFMNKEINKRYVATIEGKLEKTSGEICLPLRGDFDDRP 474

Query: 124 KQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHML---ALGHPILGDRF 180
           KQ VC+E GK A+T ++++E   DNT+++ L PITGR+HQLR+H      L  PI+GD  
Sbjct: 475 KQMVCHEHGKYAETHWQLIE-EVDNTSKLFLYPITGRTHQLRMHCAHPDGLNLPIIGDSL 533

Query: 181 YASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
           Y        A RL LHA+ L+ THP     +TF+   +F
Sbjct: 534 YGHS-----ADRLHLHAQRLSFTHPITKELLTFEVAENF 567


>UniRef50_B7I1Q3 Dual specificity pseudouridine synthase n=17 Tax=Acinetobacter
           RepID=B7I1Q3_ACIB5
          Length = 229

 Score =  179 bits (453), Expect = 8e-44,   Method: Compositional matrix adjust.
 Identities = 92/202 (45%), Positives = 129/202 (63%), Gaps = 2/202 (0%)

Query: 19  QDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDMATSGVIVVALTKA 78
           +DD ++VV+KP+GLLSV GRL EH DS   R+   +P A+  HRLDMATSG+++ A  + 
Sbjct: 29  EDDDLIVVDKPAGLLSVMGRLPEHHDSAYLRVLEKFPLAKVTHRLDMATSGLLMFAKHRD 88

Query: 79  AERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYETGKPAQTE 138
           AE  + + F+ R  KK Y+A V G     EG V++PLI DW NRP+Q V +E GK A+T 
Sbjct: 89  AEVAVSKMFQARTVKKHYIALVQGQVK-QEGRVEVPLITDWENRPRQIVHFELGKHAKTL 147

Query: 139 YEVVEY-AADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARAMAPRLLLHA 197
           ++ + Y    + +RV+L+P+TGRSHQLRVHM+ +GHPI+GD+ Y     R    R+ LHA
Sbjct: 148 FQPLVYDETTDQSRVLLEPVTGRSHQLRVHMMHIGHPIMGDKLYHPEPKRFHLNRMALHA 207

Query: 198 EMLTITHPAYGNSMTFKAPADF 219
             L   HP  G  +  ++   F
Sbjct: 208 AYLAFQHPLKGTDVVIESQVPF 229


>UniRef50_A9BWX6 Pseudouridine synthase n=2 Tax=Comamonadaceae RepID=A9BWX6_DELAS
          Length = 245

 Score =  176 bits (447), Expect = 3e-43,   Method: Compositional matrix adjust.
 Identities = 93/212 (43%), Positives = 131/212 (61%), Gaps = 8/212 (3%)

Query: 16  ILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDMATSGVIVVAL 75
            LY+D  ++V++KPSGLL VPGR  + +D +  R  + +P A  VHRLD ATSG++V+A 
Sbjct: 34  CLYEDAELLVLDKPSGLLCVPGRGPDKQDCLSGRALQRWPDALVVHRLDQATSGLVVMAR 93

Query: 76  TKAAERELKRQFREREPKKQYVARVWGHPSPAEG----LVDLPLICDWPNRPKQKVCYET 131
           + A++R L   F +R   K YVA V G P+  +      +DLP+  DW  RP + +    
Sbjct: 94  SLASQRLLSEAFAQRRVHKLYVAVVAGRPAAQQADAWQSIDLPIAADWERRPLRIIDALQ 153

Query: 132 GKPAQTEYEVVEYAADN----TARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEAR 187
           GKP+QT +  +  A +     T RV L+P+TGR+HQLRVHM ALGH ILGD  YA    +
Sbjct: 154 GKPSQTLWRAMPAATEGHDTPTTRVQLQPVTGRTHQLRVHMAALGHAILGDALYADAAVQ 213

Query: 188 AMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
           A++PRLLLHA  L + HP  G ++ F++   F
Sbjct: 214 ALSPRLLLHAHQLELAHPLSGQTLRFESAVPF 245


>UniRef50_A6VZC6 Pseudouridine synthase n=2 Tax=Marinomonas RepID=A6VZC6_MARMS
          Length = 212

 Score =  176 bits (445), Expect = 7e-43,   Method: Compositional matrix adjust.
 Identities = 99/207 (47%), Positives = 130/207 (62%), Gaps = 4/207 (1%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDMATSGVIVV 73
           L ILY+D+   V+NKP+  LSVPGR  +  DS++ R +  + +A ++HRLD ATSG+I+V
Sbjct: 9   LEILYEDEWFAVINKPANCLSVPGRGPDKLDSILYRAECLFGEAFAIHRLDEATSGLILV 68

Query: 74  ALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCY-ETG 132
           A T   ++ +   FRERE +K+Y A + GH    +G V  PL CDWPNRP+Q +C  E  
Sbjct: 69  AKTHECQKRMYAHFREREVQKEYRALLRGHLLGEKGEVRKPLRCDWPNRPRQIICTDEWS 128

Query: 133 KPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARAMAPR 192
           K + T +E + Y  +NT RV L P TGRSHQLRVHM +LGH I+GD FY  PE +   PR
Sbjct: 129 KDSITYWEKMAY-ENNTTRVRLVPFTGRSHQLRVHMQSLGHSIIGDEFY-DPEFQN-DPR 185

Query: 193 LLLHAEMLTITHPAYGNSMTFKAPADF 219
           LLLHA  L   HP     + F A   F
Sbjct: 186 LLLHAYRLEFRHPFTKAWIAFVAACPF 212


>UniRef50_B0VCN8 Pseudouridine synthase n=16 Tax=Acinetobacter RepID=B0VCN8_ACIBY
          Length = 212

 Score =  176 bits (445), Expect = 7e-43,   Method: Compositional matrix adjust.
 Identities = 95/207 (45%), Positives = 129/207 (62%), Gaps = 6/207 (2%)

Query: 16  ILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDMATSGVIVVAL 75
           ++Y+DD  MV++KPS +LSVPG+ + H DSV+TR+    P+   +HRLD  TSG++V  L
Sbjct: 9   LIYRDDDFMVIHKPSDILSVPGKGDLH-DSVLTRLVAIEPRTLLIHRLDRDTSGILVFGL 67

Query: 76  TKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYETGKPA 135
           +K  +  + RQF++R+  K Y A V GH    EG VD+P++ D    P   V     KPA
Sbjct: 68  SKRGQSAIARQFQDRQTSKIYEALVAGHLE-GEGTVDIPVVYDPSRPPLHIVDASHNKPA 126

Query: 136 QTEYEVVEY---AADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARAMAPR 192
            T ++ +E+         RV L PITGRSHQLRVHM  LGHPI+GD  YA+PE + + PR
Sbjct: 127 LTHWQAIEHFQIQGQPVTRVKLTPITGRSHQLRVHMQYLGHPIVGDTLYAAPE-QLLVPR 185

Query: 193 LLLHAEMLTITHPAYGNSMTFKAPADF 219
           L LHA+ L+  HP  G S+TF  P  F
Sbjct: 186 LCLHAKQLSFNHPVTGESLTFNCPVPF 212


>UniRef50_A8UMR7 Pseudouridine synthase n=1 Tax=Flavobacteriales bacterium ALC-1
           RepID=A8UMR7_9FLAO
          Length = 561

 Score =  174 bits (442), Expect = 1e-42,   Method: Compositional matrix adjust.
 Identities = 98/212 (46%), Positives = 133/212 (62%), Gaps = 14/212 (6%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES---VHRLDMATSGV 70
           L I+Y+DD ++V+NKP   LSVPG+    KDSV+TR+Q   P A     +HRLDM+TSG+
Sbjct: 358 LEIIYEDDFLVVLNKPHEFLSVPGKT--IKDSVLTRMQNYLPDATGPLLLHRLDMSTSGL 415

Query: 71  IVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYE 130
           ++VA  +   + L++QF +R  KK+YVA + G   P+EG +DLPL  D  NRP+Q VC E
Sbjct: 416 LLVAKNERTHKNLQKQFIKRIVKKRYVALLNGKLEPSEGTIDLPLRVDLNNRPRQLVCDE 475

Query: 131 TGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHML---ALGHPILGDRFYASPEAR 187
            GK A+T+YEV+E   +N  R+   PITGR+HQLRVH      L  PI+GD  Y +    
Sbjct: 476 HGKLAKTKYEVIE-IKNNKTRIHFYPITGRTHQLRVHAAHYKGLNMPIIGDDLYGTA--- 531

Query: 188 AMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
             + RL LHAEML+  HP     ++F   A F
Sbjct: 532 --SNRLHLHAEMLSFEHPVKREWVSFSCKAPF 561


>UniRef50_D0KW62 Pseudouridine synthase n=1 Tax=Halothiobacillus neapolitanus c2
           RepID=D0KW62_HALNC
          Length = 222

 Score =  174 bits (442), Expect = 1e-42,   Method: Compositional matrix adjust.
 Identities = 94/209 (44%), Positives = 135/209 (64%), Gaps = 4/209 (1%)

Query: 11  EPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDMATSGV 70
           EPW ++    D  +++ KP+ +L+ PG+     DS++TR+ +++P+A  VHRLD  TSGV
Sbjct: 18  EPWRLLAETAD-FLIIAKPTRMLTQPGKEAHKTDSLITRVNQEFPEARIVHRLDWDTSGV 76

Query: 71  IVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYE 130
           +V+A    A R L   F++R  KK Y+A V   P+P +GL+D P+  D  +RP+ ++  E
Sbjct: 77  MVLARHARAHRALSIAFQDRRTKKCYIAHVDRAPAPPQGLIDRPIGSDREHRPRYRIDEE 136

Query: 131 TGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARAMA 190
            G+P+QT Y V+   AD  AR+ L+PITGRSHQLRVH+L++GHPI GD  Y  P A+  A
Sbjct: 137 QGRPSQTRYVVLNETAD-FARLALEPITGRSHQLRVHLLSIGHPIQGDTLY-HPHAQNHA 194

Query: 191 PRLLLHAEMLTITHPAYGNSMTFKAPADF 219
            RL+LHAE L+   PA G + TF  P  F
Sbjct: 195 -RLMLHAESLSFPDPASGITQTFSDPVPF 222


>UniRef50_Q12RE8 Pseudouridine synthase n=83 Tax=Bacteria RepID=Q12RE8_SHEDO
          Length = 593

 Score =  169 bits (428), Expect = 7e-41,   Method: Compositional matrix adjust.
 Identities = 96/223 (43%), Positives = 136/223 (60%), Gaps = 18/223 (8%)

Query: 7   NPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES---VHRL 63
           NP  +  + ++YQD+H++V++KP+  LSVPG+     DSV TRI RD+P A     VHRL
Sbjct: 379 NPADDKQITVIYQDEHLLVISKPAEFLSVPGK--NISDSVHTRIIRDFPSASGPIIVHRL 436

Query: 64  DMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWG----HPSPAEGLVDLPLICDW 119
           DM+TSG++V+AL K A   L++QF  R   K+Y+A + G      +  EG++ LPL  D 
Sbjct: 437 DMSTSGLMVIALNKEAHESLQKQFILRTVTKRYIALLDGLLPNRTAGDEGIISLPLRGDL 496

Query: 120 PNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHML---ALGHPIL 176
            +RP+Q VC+E GK A+T +++++     T +V L P TGR+HQLRVH      L  PI+
Sbjct: 497 DDRPRQLVCHEHGKSAETRWQIIDIQQGRT-KVFLYPKTGRTHQLRVHCAHSQGLHLPIV 555

Query: 177 GDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
           GD  Y        A RL LHAE L+ THP    ++ F+  ADF
Sbjct: 556 GDDHYG-----VRASRLHLHAESLSFTHPQSREALHFQLDADF 593


>UniRef50_Q6FCX9 Pseudouridine synthase n=1 Tax=Acinetobacter sp. ADP1
           RepID=Q6FCX9_ACIAD
          Length = 214

 Score =  165 bits (417), Expect = 1e-39,   Method: Compositional matrix adjust.
 Identities = 89/207 (42%), Positives = 125/207 (60%), Gaps = 4/207 (1%)

Query: 16  ILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDMATSGVIVVAL 75
           ++++D+  MV++KP+G+LSVPG+ +   DS++ R+    P+   +HRLD  TSG++V  L
Sbjct: 9   LIHRDNDFMVIHKPAGILSVPGKGDALFDSLLVRLVEIEPKTLLIHRLDRDTSGILVFGL 68

Query: 76  TKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYETGKPA 135
            K A+  + RQF+ER+  K Y A V G     EGL+D+P++ D    P         KPA
Sbjct: 69  NKMAQSAISRQFQERQTDKIYQALVVGEVY-GEGLIDVPVVYDAARPPLHIADPAHHKPA 127

Query: 136 QTEYEVVEYAADN---TARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARAMAPR 192
           QTE++ +E    N     R+ L PITGRSHQLRVHM  +GHPI+GD  YAS   + +  R
Sbjct: 128 QTEWQALEQFELNGKMVTRMRLTPITGRSHQLRVHMQYIGHPIVGDTLYASLADQQLVSR 187

Query: 193 LLLHAEMLTITHPAYGNSMTFKAPADF 219
           L LHAE L+  HP  G  +TF  P  F
Sbjct: 188 LCLHAEQLSFYHPKTGELVTFHCPVPF 214


>UniRef50_C8Q1E7 Pseudouridine synthase n=1 Tax=Enhydrobacter aerosaccus SK60
           RepID=C8Q1E7_9GAMM
          Length = 243

 Score =  164 bits (415), Expect = 2e-39,   Method: Compositional matrix adjust.
 Identities = 93/212 (43%), Positives = 130/212 (61%), Gaps = 10/212 (4%)

Query: 15  VILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDMATSGVIVVA 74
           V LY+DD I V++KP GLLSV G+  E K S+ +R+ +  P  + +HRLDM TSG+I+ A
Sbjct: 35  VTLYRDDDIWVIDKPHGLLSVDGK--ELKVSLQSRLLKADPNVKLIHRLDMDTSGIIIFA 92

Query: 75  LTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYETGKP 134
               A+  + +QF +R P K+Y A VWG P P +G +D+P+  D P +PK  V     K 
Sbjct: 93  RHSEAQTHISKQFIDRIPSKEYQALVWGTP-PQQGEIDVPVRYDPPQKPKHIVDMSWDKR 151

Query: 135 AQTEYEVVEY---AADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYA----SPEAR 187
           A T+YE + +        +RV L P+TGRSHQLRVHML +GH +LGD  YA    + +A 
Sbjct: 152 AYTKYETLHHELREGKAVSRVALYPVTGRSHQLRVHMLHIGHVMLGDPIYAQDVLNGQAF 211

Query: 188 AMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
            ++PRL LHA  L + HP  G  M +++P  F
Sbjct: 212 DLSPRLCLHARKLRLKHPNTGVWMEWESPVPF 243


>UniRef50_A0Y082 Pseudouridine synthase n=2 Tax=Alteromonadales RepID=A0Y082_9GAMM
          Length = 235

 Score =  161 bits (408), Expect = 1e-38,   Method: Compositional matrix adjust.
 Identities = 86/212 (40%), Positives = 124/212 (58%), Gaps = 8/212 (3%)

Query: 16  ILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRD-------YPQAESVHRLDMATS 68
           ILYQD+ I+V+NKPSGLLS+ G+  E+ DSV  R+          + +A+ VHRLD+ TS
Sbjct: 24  ILYQDNDILVINKPSGLLSLSGKNSENWDSVHYRLVNGQKGLTPAFLKAKLVHRLDLGTS 83

Query: 69  GVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVC 128
           G+++V+L   + + L +QF+ R  KK YVA + G  S   G +D P+  D    P+ K+C
Sbjct: 84  GIMLVSLNDVSSKHLNKQFQLRSVKKHYVAVLQGCISEDRGQIDAPIAKDTQLFPRVKIC 143

Query: 129 YETGKPAQTEYEVVEYAADNTARVV-LKPITGRSHQLRVHMLALGHPILGDRFYASPEAR 187
              GKPA TE+ V++  A+     V   P+TGR+HQLR+H   +GHPILG   Y S  + 
Sbjct: 144 KLEGKPAVTEFNVIKRLANPVRTYVHFSPLTGRTHQLRIHSHFIGHPILGCDLYKSAHSE 203

Query: 188 AMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
            ++ RL LHA  L   HP    ++    P+ F
Sbjct: 204 KLSKRLQLHASDLFFEHPTTNQAIHIHCPSPF 235


>UniRef50_Q26D11 Pseudouridine synthase n=2 Tax=Flavobacteria RepID=Q26D11_9BACT
          Length = 561

 Score =  161 bits (407), Expect = 2e-38,   Method: Compositional matrix adjust.
 Identities = 94/219 (42%), Positives = 126/219 (57%), Gaps = 14/219 (6%)

Query: 7   NPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES---VHRL 63
           NP  +  + ++Y+DD I++VNKP   LSVPG+    KDSV +R++  YP A     VHRL
Sbjct: 351 NPGIDKTMEVIYEDDAIIIVNKPEEFLSVPGKT--IKDSVYSRLKELYPDATGPILVHRL 408

Query: 64  DMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRP 123
           DM+TSG++V          ++ QF  R   K+YVA + G     EG+++LPL  D  NRP
Sbjct: 409 DMSTSGILVATKNLEYYHFIQEQFINRTISKRYVALLNGVLENNEGMIELPLRVDLDNRP 468

Query: 124 KQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHML---ALGHPILGDRF 180
            Q VCYE GK A+T+Y+V+E     T  V   PITGR+HQLRVH      L  PI+GD  
Sbjct: 469 TQLVCYEYGKSARTKYQVLERREKETL-VHFYPITGRTHQLRVHAAHASGLNAPIVGDDL 527

Query: 181 YASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
           Y +        RL LHAE +   HP    +++FKAP  F
Sbjct: 528 YGTA-----TNRLHLHAEFIKFIHPITHKTVSFKAPVPF 561


>UniRef50_B7VRG6 Pseudouridine synthase n=4 Tax=Vibrionales RepID=B7VRG6_VIBSL
          Length = 563

 Score =  159 bits (403), Expect = 5e-38,   Method: Compositional matrix adjust.
 Identities = 92/219 (42%), Positives = 127/219 (57%), Gaps = 14/219 (6%)

Query: 7   NPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES---VHRL 63
           NP       I+Y+DD I+VVNKP   LSVPG+  E  DSV TRI+  YP A     +HRL
Sbjct: 353 NPAVGKSFDIVYEDDEIVVVNKPEEFLSVPGKFIE--DSVYTRIKARYPDATGPLIIHRL 410

Query: 64  DMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRP 123
           DM+TSG++++ALT  + + +++QF +R  +K+Y A + G      G + LPL  D  +RP
Sbjct: 411 DMSTSGLLILALTAESNKHIQKQFIDRTVEKRYTALLDGEIDGKSGDISLPLRGDITDRP 470

Query: 124 KQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHML---ALGHPILGDRF 180
           +Q VC+E G+ A+T +E V    +   +V L P TGR+HQLRVH      LG PI GD  
Sbjct: 471 RQLVCHEHGRNAETHWEAVS-TNNGKTKVHLYPKTGRTHQLRVHCAHPSGLGVPIRGDDL 529

Query: 181 YASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
           Y          RL LHA  L + HP  G  + F+ P++F
Sbjct: 530 YGYKR-----ERLHLHAGYLKLIHPTTGEWIEFEVPSEF 563


>UniRef50_C7PHX6 Pseudouridine synthase n=1 Tax=Chitinophaga pinensis DSM 2588
           RepID=C7PHX6_CHIPD
          Length = 570

 Score =  159 bits (402), Expect = 7e-38,   Method: Compositional matrix adjust.
 Identities = 94/212 (44%), Positives = 128/212 (60%), Gaps = 15/212 (7%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAE--SVHRLDMATSGVI 71
           L I+YQD+ ++VVNKPSGL SVPG   +  DSV TR++      E   VHRLDM TSG++
Sbjct: 368 LDIIYQDESVVVVNKPSGLRSVPGVTIQ--DSVYTRLKHALGDIEPLIVHRLDMDTSGLL 425

Query: 72  VVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYET 131
           VVA T+AA + ++RQF +R   K+Y A +      +EG +DLPL  D  NRP+Q VC+ T
Sbjct: 426 VVAKTQAAHKHIQRQFLQRTVSKRYTALLSKVIDTSEGEIDLPLTADLFNRPRQIVCFTT 485

Query: 132 GKPAQTEYEVV-EYAADNTARVVLKPITGRSHQLRVHM---LALGHPILGDRFYASPEAR 187
           GK + T ++VV  Y A    ++   P+TGR+HQLR+H    L L  PI+GD  Y +    
Sbjct: 486 GKKSVTRWKVVTRYQA--MTKIDFWPLTGRTHQLRMHSAHPLGLNAPIVGDDLYGTA--- 540

Query: 188 AMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
             A R+ LHA  +  THP     ++F AP  F
Sbjct: 541 --AERMYLHAAHIEFTHPLSRQRISFDAPVTF 570


>UniRef50_A6LDZ7 Pseudouridine synthase n=26 Tax=Bacteroidales RepID=A6LDZ7_PARD8
          Length = 549

 Score =  158 bits (399), Expect = 1e-37,   Method: Compositional matrix adjust.
 Identities = 98/215 (45%), Positives = 128/215 (59%), Gaps = 15/215 (6%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES---VHRLDMA 66
           +E  L ILY+DD+++V+NKP G+LSVPG+ +   DSV  R+   YP+A     VHRLDMA
Sbjct: 336 RETKLDILYEDDYLLVINKPEGMLSVPGKGD--ADSVYQRLSILYPEATGPIIVHRLDMA 393

Query: 67  TSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQK 126
           TSG+++ A TK A + L+ QF+ R  +K+Y+A + G     EG + LPL  D  +RP+Q 
Sbjct: 394 TSGLLLAAKTKEAHQNLQAQFKNRTIQKRYIALLEGEVPQDEGEIRLPLCPDPLDRPRQI 453

Query: 127 VCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHM---LALGHPILGDRFYAS 183
           V  E GKPA T Y V+E  +  T  +   P TGR+HQLRVH    L L  PILGD  Y  
Sbjct: 454 VSEEFGKPALTHYRVLERTSGKTL-IAFYPQTGRTHQLRVHAAHPLGLHCPILGDELYGR 512

Query: 184 PEARAMAPRLLLHAEMLTITHPAYGNSMTF-KAPA 217
                 A RL LHAE L  THP     +   K+PA
Sbjct: 513 -----KAERLYLHAEYLAFTHPITSERIEIQKSPA 542


>UniRef50_Q6AIJ2 Probable ribosomal large subunit pseudouridine synthase A n=1
           Tax=Desulfotalea psychrophila RepID=Q6AIJ2_DESPS
          Length = 211

 Score =  156 bits (394), Expect = 5e-37,   Method: Compositional matrix adjust.
 Identities = 90/212 (42%), Positives = 122/212 (57%), Gaps = 10/212 (4%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES---VHRLDMATSGV 70
           L I+Y+DDH++VV KP GLLSVPGR  E+ D V +R+Q   P+  +   VHRLDM TSG+
Sbjct: 4   LKIIYRDDHLVVVIKPGGLLSVPGRGPENSDCVSSRLQAKIPEMITQPAVHRLDMYTSGL 63

Query: 71  IVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYE 130
           +V A++K   R L  QF+E++  K+Y A + G      G + LP   D  NRP Q + Y+
Sbjct: 64  MVYAVSKEIHRALSIQFQEQQVDKKYTALLEGCLQEVSGEIRLPFRVDLDNRPIQILDYQ 123

Query: 131 TGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHML---ALGHPILGDRFYASPEAR 187
            GK   T +  ++   +   RV   P+TGR+HQLRVH      LG PI+GD FY S    
Sbjct: 124 HGKMGITLWRKMD-EKNGITRVEFTPMTGRTHQLRVHAAHAKGLGIPIIGDSFYGSGRD- 181

Query: 188 AMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
                ++LHA  L+ THP  G  + FK   DF
Sbjct: 182 --GDEMMLHAHQLSFTHPIIGEKLYFKNDPDF 211


>UniRef50_A6TAT3 Pseudouridine synthase n=57 Tax=Bacteria RepID=A6TAT3_KLEP7
          Length = 263

 Score =  154 bits (390), Expect = 2e-36,   Method: Compositional matrix adjust.
 Identities = 87/222 (39%), Positives = 122/222 (54%), Gaps = 10/222 (4%)

Query: 8   PPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDMAT 67
           PP    + +LYQD+H++++NKP+GLLS+ G+   + DSV  R+ + YP    VHRLD  T
Sbjct: 42  PPCREQITLLYQDEHLVLINKPAGLLSLSGKDPRNLDSVHHRLVQRYPGCTLVHRLDFGT 101

Query: 68  SGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKV 127
           SG++V+A  K     L +QF +R   K Y A + GH +  EG+V+  +  D    P+  +
Sbjct: 102 SGLMVIARNKGINALLCQQFSQRTVDKVYTALLCGHLAEDEGIVEAAIAKDPARFPRMAL 161

Query: 128 CYETGKPAQTEYEVVE--YAADN------TARVVLKPITGRSHQLRVHMLALGHPILGDR 179
           C   GKPA++ Y V++  Y A          RV L P TGR+HQLR+H   LG+PILG  
Sbjct: 162 CARHGKPARSRYRVIDRLYQAREGERALALTRVTLTPETGRTHQLRIHCQLLGYPILGCD 221

Query: 180 FYASPE--ARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
            Y   E      APRL+LHA  L   HP     M  +  + F
Sbjct: 222 LYGGRELPGTEQAPRLMLHASELRFVHPVSHEPMHIQQASPF 263


>UniRef50_C7QW59 Pseudouridine synthase n=5 Tax=Cyanobacteria RepID=C7QW59_CYAP0
          Length = 551

 Score =  154 bits (389), Expect = 2e-36,   Method: Compositional matrix adjust.
 Identities = 88/210 (41%), Positives = 125/210 (59%), Gaps = 10/210 (4%)

Query: 2   GMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAE--- 58
           G+ N     +  + ++Y+D  I+ ++KPSGLLSVPGR  E  DSV+TR+Q   P A+   
Sbjct: 332 GLGNNQSFFKSEIKVIYEDQWIIAIDKPSGLLSVPGRYFETFDSVLTRLQNSLPDAQELR 391

Query: 59  SVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICD 118
           +VHRLD  TSG++++A  +   R L +QF +R+ +K Y A + G     EG++ LPL  D
Sbjct: 392 TVHRLDQDTSGILLLARDRYTHRHLSQQFAQRKVEKIYEAILAGSVMMNEGVIQLPLWGD 451

Query: 119 WPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHML---ALGHPI 175
             NRP QKV +E GKP+ T+++V+    +N  R+   P+TGR+HQ+RVH +    LG  I
Sbjct: 452 PNNRPYQKVDWELGKPSITQFKVIT-TQENLTRIQFIPLTGRTHQIRVHAVDTQGLGSVI 510

Query: 176 LGDRFYASPEARAMAPRLLLHAEMLTITHP 205
           LGD  Y      A   RL LHA  L   HP
Sbjct: 511 LGDYLYG---CNAGVSRLHLHARELKFEHP 537


>UniRef50_D1PU24 Pseudouridine synthase n=1 Tax=Prevotella bergensis DSM 17361
           RepID=D1PU24_9BACT
          Length = 421

 Score =  154 bits (389), Expect = 2e-36,   Method: Compositional matrix adjust.
 Identities = 97/212 (45%), Positives = 125/212 (58%), Gaps = 18/212 (8%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES---VHRLDMATSGV 70
           L I+Y+DD + VV+KP+G+LSVPG+    ++SV+  ++R  P A     VHRLDMATSG+
Sbjct: 222 LKIVYEDDTLCVVDKPAGMLSVPGK--GCRESVLDVMRRRCPDATGALVVHRLDMATSGL 279

Query: 71  IVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYE 130
           +VVA T  A REL+RQF  R  +K+YVA +   P   +G + LPL  D  +RP+Q V   
Sbjct: 280 MVVAKTAEAYRELQRQFATRSVRKRYVAILSRQPREPKGEIALPLRPDLDDRPRQVVDSV 339

Query: 131 TGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHML---ALGHPILGDRFYASPEAR 187
            GKPA T YE++     +  RV L P TGR+HQLRVH      L  PI GD  Y      
Sbjct: 340 YGKPALTHYEII-----DGCRVALYPRTGRTHQLRVHCAHRDGLDSPIKGDELYGR---- 390

Query: 188 AMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
             A RL LHAE L   HPA G  + F + A F
Sbjct: 391 -RAERLYLHAEWLAFRHPATGEEVEFTSVAPF 421


>UniRef50_Q5E092 Pseudouridine synthase n=3 Tax=Aliivibrio RepID=Q5E092_VIBF1
          Length = 576

 Score =  154 bits (389), Expect = 2e-36,   Method: Compositional matrix adjust.
 Identities = 88/212 (41%), Positives = 124/212 (58%), Gaps = 14/212 (6%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES---VHRLDMATSGV 70
           L I+Y+DD +++VNKP   LSV G+     DSV  RIQ  YP A     VHRLDM+TSG+
Sbjct: 373 LEIVYEDDVLVIVNKPVEFLSVSGKYI--SDSVHARIQARYPNATGPLIVHRLDMSTSGL 430

Query: 71  IVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYE 130
           +V+ LT  + +++++QF ER  +K+Y A + G+     G ++LPL  D  +RP+Q V ++
Sbjct: 431 LVLTLTAESNKQVQKQFIERTVEKRYTALLEGNIETDNGTINLPLTGDMEDRPRQMVNHK 490

Query: 131 TGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRV---HMLALGHPILGDRFYASPEAR 187
           +G+ A+T Y+V+      T +V L P TGR+HQLRV   H   L  PI+GD  Y      
Sbjct: 491 SGRKAETHYQVIAQEGKRT-KVHLYPHTGRTHQLRVHCAHQAGLNTPIVGDDLYGFK--- 546

Query: 188 AMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
             A RL LHA  L   HP    ++ F  P DF
Sbjct: 547 --ADRLHLHAGYLKFKHPTTNETVEFSCPEDF 576


>UniRef50_Q0F1Z5 Pseudouridine synthase n=1 Tax=Mariprofundus ferrooxydans PV-1
           RepID=Q0F1Z5_9PROT
          Length = 579

 Score =  154 bits (388), Expect = 3e-36,   Method: Compositional matrix adjust.
 Identities = 90/212 (42%), Positives = 126/212 (59%), Gaps = 16/212 (7%)

Query: 16  ILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES---VHRLDMATSGVIV 72
           I+Y+DD ++VVNKP+GL+S PGR  E ++S+ +R+ + YPQ      VHRLDM TSG+++
Sbjct: 376 IVYEDDQLLVVNKPAGLMSTPGR--EIEESLFSRLAQRYPQIPELTLVHRLDMDTSGLLL 433

Query: 73  VALTKAAERELKRQFREREPKKQYVARVWGH--PSPAEGLVDLPLICDWPNRPKQKVCYE 130
           VA      + L++QF ER  +K Y A +       P +G ++LPL  D  +RP+Q VCY+
Sbjct: 434 VAKDLRTHKRLQKQFIERSVEKCYEAVLVKRLPAQPDQGRIELPLRVDLDDRPRQMVCYQ 493

Query: 131 TGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHML---ALGHPILGDRFYASPEAR 187
            GKPA T ++++    +N  R+   P TGR+HQLRVH      L   I+GD  Y  P   
Sbjct: 494 HGKPATTRWQIIAR-ENNRTRIWFYPETGRTHQLRVHASHRDGLNAAIVGDGLYGLP--- 549

Query: 188 AMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
             A RL+LHA  L  THP     M F+ PA F
Sbjct: 550 --AERLMLHARRLCFTHPVSREPMVFELPAPF 579


>UniRef50_Q1CZL9 Pseudouridine synthase n=5 Tax=Proteobacteria RepID=Q1CZL9_MYXXD
          Length = 559

 Score =  153 bits (387), Expect = 4e-36,   Method: Compositional matrix adjust.
 Identities = 92/212 (43%), Positives = 124/212 (58%), Gaps = 12/212 (5%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESV---HRLDMATSGV 70
           L I+++D+ ++VV KP GLLSVP +    +DSV+ R++   P+A      HRLD+ TSG+
Sbjct: 354 LDIVFEDEWLVVVEKPEGLLSVPAKDVSVEDSVLARLRARAPEAAGTMLAHRLDLDTSGL 413

Query: 71  IVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYE 130
           +V A        L+RQF  RE  K+Y A V G+     G +D P+  D  +RP+Q     
Sbjct: 414 LVAAKDARTYAALQRQFAGREVHKRYAAWVEGNVQGERGTIDFPMRVDLDDRPRQIHDPV 473

Query: 131 TGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHM---LALGHPILGDRFYASPEAR 187
            GKPA TE+ V+E +   T +V L P+TGR+HQLRVH    L LG PI+GDR Y  P   
Sbjct: 474 HGKPAVTEWHVLERSHGRT-KVALFPLTGRTHQLRVHAAHPLGLGAPIVGDRLYGHP--- 529

Query: 188 AMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
              PRL LHAE L+  HP  G  +T + PA F
Sbjct: 530 --GPRLHLHAEALSFQHPVTGQRLTLERPAPF 559


>UniRef50_B7BE87 Pseudouridine synthase n=8 Tax=Bacteroidales RepID=B7BE87_9PORP
          Length = 551

 Score =  152 bits (384), Expect = 8e-36,   Method: Compositional matrix adjust.
 Identities = 97/218 (44%), Positives = 125/218 (57%), Gaps = 19/218 (8%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES---VHRLDMATSGV 70
           L I+Y+D+ ++VVNKP+G+LSVPG+ +   DSV  R++R YP A     VHRLDMATSG+
Sbjct: 337 LEIVYEDESLLVVNKPAGMLSVPGKSD--VDSVYQRVRRMYPGATGPMVVHRLDMATSGL 394

Query: 71  IVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYE 130
           ++VA TK   + L+ QF+ R   K+YVA + G     EG ++LPL  D  +RP+Q V   
Sbjct: 395 MLVAKTKEVHQNLQAQFKNRTVCKRYVAWLDGIVEEKEGHLELPLRPDPEDRPRQVVDVV 454

Query: 131 TGKPAQTEYEVVEYAADNTAR------VVLKPITGRSHQLRVHM---LALGHPILGDRFY 181
            GKPA T+Y V+ Y             V   P TGR+HQLRVH    L L  PI+GD  Y
Sbjct: 455 HGKPAVTDYRVLRYGGCKGGLRTTPTVVSFVPKTGRTHQLRVHSAHPLGLNAPIVGDELY 514

Query: 182 ASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
                   A RL LHAE L  THP  G  M  +  A F
Sbjct: 515 GKK-----ADRLYLHAEYLGFTHPVSGVYMEVEKEAGF 547


>UniRef50_B1XN95 Pseudouridine synthase n=1 Tax=Synechococcus sp. PCC 7002
           RepID=B1XN95_SYNP2
          Length = 538

 Score =  152 bits (384), Expect = 9e-36,   Method: Compositional matrix adjust.
 Identities = 87/209 (41%), Positives = 127/209 (60%), Gaps = 12/209 (5%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDMATSGVIVV 73
           L I+Y+D  ++ ++KP+GL S+PGR  +  DS  +R++RDY     VHRLD  TSG+++ 
Sbjct: 339 LEIIYEDHSLIAIHKPAGLPSIPGRSSQTYDSAFSRLRRDYQDIFLVHRLDQDTSGILLF 398

Query: 74  ALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYETGK 133
           A     +++L+ QFR R+  K+Y A +       EG++ LPL  D  +RP+QKV  + GK
Sbjct: 399 AKNAETQQDLQTQFRRRKIHKEYEALLEEKIQRPEGMITLPLWADPGDRPRQKVDAQRGK 458

Query: 134 PAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHML---ALGHPILGDRFYASPEARAMA 190
           P++T +  +     ++ R+ LKPITGR+HQLRVH      L +PILGDR Y +   RA A
Sbjct: 459 PSETYFVKL-----DSHRLKLKPITGRTHQLRVHCAHPNGLNNPILGDRLYGN---RA-A 509

Query: 191 PRLLLHAEMLTITHPAYGNSMTFKAPADF 219
           PRL L A  LT  HP   N  T ++  +F
Sbjct: 510 PRLHLQATALTFMHPETKNPHTIQSAPEF 538


>UniRef50_A5WHV7 Pseudouridine synthase n=3 Tax=Psychrobacter RepID=A5WHV7_PSYWF
          Length = 237

 Score =  152 bits (383), Expect = 9e-36,   Method: Compositional matrix adjust.
 Identities = 85/210 (40%), Positives = 131/210 (62%), Gaps = 7/210 (3%)

Query: 15  VILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDMATSGVIVVA 74
           V +Y+D+ +++V+KP+GLLS+ G+  + K S+++R++R  P+ + +HRLDM TSG+++ A
Sbjct: 30  VTVYEDEDLLLVDKPAGLLSIDGK--DLKVSLLSRLERANPEVKLIHRLDMDTSGLMIFA 87

Query: 75  LTKAAERELKRQFREREPKKQYVARVWGHPS--PAEGLVDLPLICDWPNRPKQKVCYETG 132
             K A+  + +QF ER P+K+Y A V G  +    +G +++P+  +   +PK     E  
Sbjct: 88  KNKQAQTHISKQFIERIPQKEYQAIVQGTLAIPGKKGEINIPVRYEPSIKPKHVADPEWK 147

Query: 133 KPAQTEYEVVEYAADN---TARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARAM 189
           K A T YEV+ +         RV L P+TGRSHQLRVHM+ LGH I+GD  YA  EA ++
Sbjct: 148 KHALTHYEVLHHELRKGRPVTRVALHPVTGRSHQLRVHMVHLGHVIIGDPIYAEGEALSL 207

Query: 190 APRLLLHAEMLTITHPAYGNSMTFKAPADF 219
           APRL LHA  L + HP     M +++   F
Sbjct: 208 APRLNLHAHKLRLKHPTMNTWMAWESAVPF 237


>UniRef50_D1PDP7 Pseudouridine synthase n=1 Tax=Prevotella copri DSM 18205
           RepID=D1PDP7_9BACT
          Length = 556

 Score =  151 bits (382), Expect = 1e-35,   Method: Compositional matrix adjust.
 Identities = 94/220 (42%), Positives = 124/220 (56%), Gaps = 22/220 (10%)

Query: 17  LYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES---VHRLDMATSGVIVV 73
           LY+D  + V+ KP GLLSVPG+ +  + SV   ++R Y +A     VHRLDMATSG++++
Sbjct: 342 LYEDRELAVIYKPEGLLSVPGK-DAAQPSVYALMRRKYQEATGPLIVHRLDMATSGLMII 400

Query: 74  ALTKAAERELKRQFREREPKKQYVARVWGHPSPA-----------EGLVDLPLICDWPNR 122
           A T+ A   L+++F     +K+YVA V G    +            G + LPLI D+ +R
Sbjct: 401 AKTEFAYHRLQKEFLNHRVQKKYVAIVCGKDKESCNRILKEAEGGRGYISLPLIADFLDR 460

Query: 123 PKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHML---ALGHPILGDR 179
           P+Q V  E GK A TEYEV+E   D   R+ L P TGR+HQLRVH      L  PI+GD 
Sbjct: 461 PRQMVNREQGKEAITEYEVLERIDDTHLRLALYPKTGRTHQLRVHCAHQEGLNAPIIGDP 520

Query: 180 FYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
            Y +      A RL LHAE +T  HP  G  MT    ADF
Sbjct: 521 LYGNEP----ATRLHLHAEEITFEHPMTGKKMTVTRKADF 556


>UniRef50_C1AE05 Pseudouridine synthase n=1 Tax=Gemmatimonas aurantiaca T-27
           RepID=C1AE05_GEMAT
          Length = 476

 Score =  148 bits (374), Expect = 1e-34,   Method: Compositional matrix adjust.
 Identities = 94/217 (43%), Positives = 121/217 (55%), Gaps = 10/217 (4%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES---VHRLDM 65
           P EP   ++Y+DDH++VVNKPSG+L+VPGR    +D VMTR++  YP A     VHRLD+
Sbjct: 264 PNEP--AVVYEDDHLLVVNKPSGMLTVPGRGPTMQDCVMTRLRARYPDATGQMVVHRLDL 321

Query: 66  ATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQ 125
            TSG+++ A        L+R F  RE  K YVA + G  +   G + LPL  D  +RP+ 
Sbjct: 322 DTSGLLLAAKDPITASALQRLFSLREIDKHYVAWLDGVVTDDHGHIHLPLRMDVDDRPRN 381

Query: 126 KVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHML---ALGHPILGDRFYA 182
                 GKPA TE++V+    D   RV   P TGR+HQLRVH      L  PI+GDR Y 
Sbjct: 382 IHDPVFGKPAHTEWQVMAR-TDGRTRVRFTPHTGRTHQLRVHAAHPDGLDAPIVGDRLYG 440

Query: 183 SPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
              A     RL LHAE L   HP  G  +  + PA F
Sbjct: 441 R-TAPDEDERLQLHAERLAFVHPVSGAKVVVEQPAPF 476


>UniRef50_A5ZGG0 Pseudouridine synthase n=4 Tax=Bacteroides RepID=A5ZGG0_9BACE
          Length = 590

 Score =  148 bits (373), Expect = 1e-34,   Method: Compositional matrix adjust.
 Identities = 95/247 (38%), Positives = 132/247 (53%), Gaps = 41/247 (16%)

Query: 7   NPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES---VHRL 63
           N  ++  L I+++D+ ++VVNKPSG+LSVPG+ EE  DSV  R++  YP A     VHRL
Sbjct: 351 NTHKDTELEIVFEDEWLVVVNKPSGMLSVPGK-EEDMDSVYHRLKEKYPDATGPMIVHRL 409

Query: 64  DMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWG--------------------- 102
           DMATSG+++VA TK   + L+ QF  R  KK+Y+A + G                     
Sbjct: 410 DMATSGLLLVAKTKEVHQHLQAQFENRSIKKRYIALLDGCITETEETTNQTTGNTRKTEK 469

Query: 103 -------HPSPAEGLVDLPLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLK 155
                    +   G ++LPL  +  +RP Q V  E GK A TEY+++  +  +T R+   
Sbjct: 470 VRATEVISTTGKVGRIELPLCPNPLDRPCQSVDEEHGKEAITEYQIITNSEKHT-RIAFC 528

Query: 156 PITGRSHQLRVHML---ALGHPILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMT 212
           P+TGR+HQLRVH      L  PILGD  Y        A RL LHAE +   HP YG+ + 
Sbjct: 529 PLTGRTHQLRVHAAHPKGLNCPILGDELYGKK-----ADRLYLHAEYIEFRHPIYGDIIC 583

Query: 213 FKAPADF 219
            +   DF
Sbjct: 584 IQKEPDF 590


>UniRef50_C5VJ38 Pseudouridine synthase n=2 Tax=Prevotella RepID=C5VJ38_9BACT
          Length = 571

 Score =  148 bits (373), Expect = 1e-34,   Method: Compositional matrix adjust.
 Identities = 93/216 (43%), Positives = 121/216 (56%), Gaps = 18/216 (8%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGR-LEEHKDSVMTRIQRDYPQAESVHRLDMATSGVIV 72
           L ILY+DD++ VV KPSGLLS+PG+  +    S++    +    A  VHRLDMATSG++V
Sbjct: 360 LQILYEDDYLAVVVKPSGLLSIPGKGCQASIYSILCERWKGKSDAFMVHRLDMATSGLLV 419

Query: 73  VALTKAAERELKRQFREREPKKQYVA----RVWGHPSPAEGLVDLPLICDWPNRPKQKVC 128
           VA T    + L+ QF  R  KK+YVA     +     PAEG ++LPL  D  +RP+Q+V 
Sbjct: 420 VARTSEVHKALQAQFIGRTVKKKYVALLPLSILEKQLPAEGRIELPLSPDPDDRPRQRVD 479

Query: 129 YETGKPAQTEYEVVEYA-----ADNTARVVLKPITGRSHQLRVHML---ALGHPILGDRF 180
              GKPA TEY ++        A    ++ L P+TGR+HQLRVH      LG PI+GD  
Sbjct: 480 RTNGKPAITEYRLIGKTTYGKEALEAVKIALYPLTGRTHQLRVHCAHPDGLGTPIIGDNL 539

Query: 181 YASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
           Y        A RL LHA  L  THP     M+F  P
Sbjct: 540 YGQ-----RAERLWLHATHLEFTHPITQERMSFDTP 570


>UniRef50_D1W0M0 Pseudouridine synthase n=1 Tax=Prevotella timonensis CRIS 5C-B1
           RepID=D1W0M0_9BACT
          Length = 566

 Score =  145 bits (367), Expect = 7e-34,   Method: Compositional matrix adjust.
 Identities = 95/218 (43%), Positives = 126/218 (57%), Gaps = 16/218 (7%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAE---SVHRLDMA 66
           Q   L ++Y+DD ++VV+KP+G+LSVPGR    + SV + ++   P +    SVHRLDMA
Sbjct: 347 QHSQLHVVYEDDALIVVDKPAGILSVPGR--SQRPSVYSILRSQMPSSVELFSVHRLDMA 404

Query: 67  TSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQK 126
           TSG++++A      R L+RQFR    +K+Y+A + G  S  EG+V LPL  D  +RP+Q 
Sbjct: 405 TSGLLILAKNSVVYRHLQRQFRTHHIQKEYIAILEGALSQREGVVTLPLRPDPFDRPRQV 464

Query: 127 VCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHML---ALGHPILGDRFYAS 183
           V +E GK A T Y V+      T  V L P TGR+HQLR+H      L  PILGD  Y  
Sbjct: 465 VDWEHGKKAVTSYRVLNVRHGKTW-VALFPETGRTHQLRMHCAHAEGLNCPILGDPLYGH 523

Query: 184 PEARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
                 A RL LHA  +T  HP  G  +T  A  PADF
Sbjct: 524 -----HANRLYLHATSITFEHPISGQLLTLHAQPPADF 556


>UniRef50_B2J8D4 Pseudouridine synthase n=7 Tax=Cyanobacteria RepID=B2J8D4_NOSP7
          Length = 575

 Score =  145 bits (366), Expect = 1e-33,   Method: Compositional matrix adjust.
 Identities = 90/216 (41%), Positives = 131/216 (60%), Gaps = 10/216 (4%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQA---ESVHRLDMA 66
           +E  L I+Y+D+ ++ VNKP GLLSVPGR  + +DSV++R++   P      SVHRLD  
Sbjct: 364 EEVTLPIIYEDEWLIAVNKPPGLLSVPGRYRDRQDSVLSRLRHLLPDGMALASVHRLDQE 423

Query: 67  TSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQK 126
           TSG++++A  +   ++L +QF++R+  K Y A + G     +G++DLPL  D  NRP QK
Sbjct: 424 TSGILLLARDRQTHKQLSQQFQQRQVHKVYEAILSGVAIAEKGVIDLPLWGDPENRPYQK 483

Query: 127 VCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVH---MLALGHPILGDRFYAS 183
           V ++ GKP+ T+++V+    D T R+   P+TGR+HQLRVH   +  LG  ILGDR Y  
Sbjct: 484 VDWQNGKPSLTQFQVISREQDYT-RIEFTPLTGRTHQLRVHAADVRGLGITILGDRLYGC 542

Query: 184 PEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
               A+  RL LHA  L   HP    ++  KA   F
Sbjct: 543 D---AVTSRLYLHARELDFEHPQLKKTLYLKAITLF 575


>UniRef50_D0P480 Ribosomal large subunit pseudouridine synthase A, putative n=1
           Tax=Phytophthora infestans T30-4 RepID=D0P480_PHYIN
          Length = 363

 Score =  145 bits (365), Expect = 1e-33,   Method: Compositional matrix adjust.
 Identities = 92/221 (41%), Positives = 123/221 (55%), Gaps = 17/221 (7%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDMATSGVIVV 73
           L IL++DD ++VVNKP+ +LSV G   +   SV   + R YP A  VHRLD  TSG++VV
Sbjct: 117 LKILFRDDAVIVVNKPANILSVDGTDPDALMSVHRCVARVYPNARMVHRLDQETSGLLVV 176

Query: 74  ALTKAAERELKRQFREREPKKQYVARVWG-------HPSPAEGLVDLPLICDWPNRPKQK 126
           ALTK+A + L  QFR+R   K YVARV G         S +   V +P+         Q 
Sbjct: 177 ALTKSAAQSLNAQFRDRSVDKTYVARVDGWMMNDLEEKSESPRRVQIPMEKHLTKSLIQH 236

Query: 127 VCYE------TGKPAQTEYEVV---EYAADNTARVV-LKPITGRSHQLRVHMLALGHPIL 176
           V  +      +   + TEY V+   E   D  + +V LKP+TG++HQLR+HM  LGHPIL
Sbjct: 237 VVSDREVDPSSSLWSTTEYSVLSRDESGDDRKSTLVELKPVTGKTHQLRLHMQHLGHPIL 296

Query: 177 GDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPA 217
           GD  Y+       A RL LHA  L+ THP     +TF++P 
Sbjct: 297 GDSLYSPDVVYHRASRLCLHAAKLSFTHPVTNERLTFESPC 337


>UniRef50_C6BRU5 Pseudouridine synthase n=1 Tax=Desulfovibrio salexigens DSM 2638
           RepID=C6BRU5_DESAD
          Length = 214

 Score =  144 bits (364), Expect = 2e-33,   Method: Compositional matrix adjust.
 Identities = 91/215 (42%), Positives = 121/215 (56%), Gaps = 10/215 (4%)

Query: 11  EPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAE---SVHRLDMAT 67
           E  L I+Y D  I+VVNKPSGLLSVPGR  E++D V+TR+Q+ +P+     +VHRLDM T
Sbjct: 4   EKLLDIVYADRKIVVVNKPSGLLSVPGRGPENQDCVVTRVQKMFPECRKFPAVHRLDMDT 63

Query: 68  SGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKV 127
           SG++V+ LT  A REL  QF++R+ KK+Y A + G      G++++    D  NRP Q  
Sbjct: 64  SGLLVLGLTARAVRELMEQFQKRQVKKRYEALLEGIVKEDSGVIEMAFRLDPYNRPYQVY 123

Query: 128 CYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHML---ALGHPILGDRFYASP 184
               GK   T +  +    +   RV   P+TGR+HQLRVH      LG PI+GDR Y S 
Sbjct: 124 DPIHGKLGITHWRKLG-VENGMTRVEFTPLTGRTHQLRVHSAHPQGLGCPIVGDRLYGSG 182

Query: 185 EARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
                  +L LHA  L   HP     M F+    F
Sbjct: 183 TEPG---QLKLHAGYLCFEHPKTKEKMEFEIAPLF 214


>UniRef50_B0JGC2 Pseudouridine synthase n=2 Tax=Microcystis aeruginosa
           RepID=B0JGC2_MICAN
          Length = 501

 Score =  143 bits (361), Expect = 4e-33,   Method: Compositional matrix adjust.
 Identities = 83/207 (40%), Positives = 121/207 (58%), Gaps = 6/207 (2%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDMATSGVIVV 73
           L I+Y+D+ I+ +NKP+GLLSV GR ++ +D+V+ R +R       VHRLD  TSG++++
Sbjct: 300 LEIIYEDEGIIAINKPAGLLSVAGRYQDSQDAVVNRFRRQGKNLIPVHRLDRETSGILLL 359

Query: 74  ALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYETGK 133
           A +    R L +QF+ RE +K Y A +        G++DLPL  +  NRP Q V ++ GK
Sbjct: 360 AKSLDIYRCLSQQFQRREVEKIYEAILSEIIERESGIIDLPLWGNPQNRPYQTVDWQRGK 419

Query: 134 PAQTEYEVVEYAADNTARVVLKPITGRSHQLRVH-MLALGHPILGDRFYASPEARAMAPR 192
            +QT ++VV     N +R+   P TGR+HQ+RVH    LG  ILGDR Y   +    + R
Sbjct: 420 ASQTYFKVVGKEG-NYSRLEFIPYTGRTHQIRVHSQQGLGIGILGDRLYNGKQ----SDR 474

Query: 193 LLLHAEMLTITHPAYGNSMTFKAPADF 219
           L LHA+ L+  HP   N +    P  F
Sbjct: 475 LHLHAKQLSFRHPQTENKLDLIIPTPF 501


>UniRef50_Q31NG5 Pseudouridine synthase n=2 Tax=Synechococcus elongatus
           RepID=Q31NG5_SYNE7
          Length = 543

 Score =  142 bits (359), Expect = 6e-33,   Method: Compositional matrix adjust.
 Identities = 83/199 (41%), Positives = 113/199 (56%), Gaps = 12/199 (6%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES---VHRLDMATSGV 70
           L ILY+D  ++ + KP+GLLSVPG     + S +  +++ +P   +   VHRLD ATSG+
Sbjct: 338 LPILYEDADLLAIIKPAGLLSVPGTRGLQQASAIQLLRQQFPDLPTYCVVHRLDQATSGI 397

Query: 71  IVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYE 130
           ++VA  +  +  L  QFR R+  K Y A + G P    G +DLPL  DW  RP Q V  +
Sbjct: 398 LLVARNRPTQVALFEQFRRRQVHKVYEALLEGQPDCTAGTIDLPLRPDWTRRPYQLVDRD 457

Query: 131 TGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHML---ALGHPILGDRFYASPEAR 187
            G+PA T Y  ++   D   R+ L+PITGR+HQLRVHM     LG PILGD  Y      
Sbjct: 458 RGRPALTYYRCIDQTGDR-CRMELEPITGRTHQLRVHMAHPEGLGQPILGDDLYGQS--- 513

Query: 188 AMAPRLLLHAEMLTITHPA 206
             + RL LHA  +   HP+
Sbjct: 514 --SDRLYLHARSIRFRHPS 530


>UniRef50_B1ZYX0 Pseudouridine synthase n=4 Tax=Verrucomicrobia RepID=B1ZYX0_OPITP
          Length = 311

 Score =  140 bits (353), Expect = 3e-32,   Method: Compositional matrix adjust.
 Identities = 89/216 (41%), Positives = 123/216 (56%), Gaps = 15/216 (6%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES----------VHRL 63
           L +L++D H++ VNK +G++  PG +   +D+++  +      + S          VHRL
Sbjct: 80  LTVLFEDKHMLAVNKAAGMVVHPG-VATSEDTLVHALLAHCAGSLSGIGGVERPGIVHRL 138

Query: 64  DMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRP 123
           D  T+GVIVVA T AA R L  QF  R  KK+YVA V G P    G +D   I   P   
Sbjct: 139 DKETTGVIVVAKTDAAHRALADQFATRTLKKEYVALVAGVPRLLSGSIDRA-IARHPVHR 197

Query: 124 KQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYA- 182
            +    E G+PA+T++E+VE   D  A V  +  TGR+HQ+RVH+ +LGHPILGD  Y  
Sbjct: 198 HRMTVGEGGRPARTDWELVEAFGDIGALVRCRIFTGRTHQIRVHLKSLGHPILGDALYGW 257

Query: 183 SPEAR-AMAP-RLLLHAEMLTITHPAYGNSMTFKAP 216
            PE R A  P R++LHAE L +THP  G  +  +AP
Sbjct: 258 KPEPRLATQPARVMLHAEHLVLTHPISGKELDLRAP 293


>UniRef50_A6FXR5 Pseudouridine synthase n=1 Tax=Plesiocystis pacifica SIR-1
           RepID=A6FXR5_9DELT
          Length = 509

 Score =  134 bits (338), Expect = 2e-30,   Method: Compositional matrix adjust.
 Identities = 92/245 (37%), Positives = 130/245 (53%), Gaps = 46/245 (18%)

Query: 16  ILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQ----------------RDYPQAES 59
           ++Y+DD ++VV+KP G+LSVPGR    +DSV  R++                +  P A S
Sbjct: 270 VVYEDDDLLVVDKPPGMLSVPGRGPRRRDSVEYRLKARANPDAIEAAVAAQSKSKPPAGS 329

Query: 60  -----------------VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWG 102
                            VHRLD+ATSG+++ A  + A   L+RQF  R+  K+YVA V G
Sbjct: 330 EARTAAGPRLDQLWPRLVHRLDLATSGLLIAAKHREAYVALQRQFSSRQIGKRYVALVRG 389

Query: 103 HPSP----AEGLVDLPLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTA-RVVLKPI 157
            P P      G ++LPL  D  +RP+QKV    GK A+T ++++ +  ++ A RV L P 
Sbjct: 390 -PLPDALGEGGEIELPLARDLDDRPRQKVDRREGKVARTRWQLLAHEPEHAASRVALYPH 448

Query: 158 TGRSHQLRVHML---ALGHPILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFK 214
           TGR+HQLR+H      L  P++GD  Y   E      RL+LHAE LT  HP  G  M  +
Sbjct: 449 TGRTHQLRLHAAHPEGLDAPLVGDLLYGYGE----GARLMLHAERLTFLHPTRGEPMELR 504

Query: 215 APADF 219
           +P  F
Sbjct: 505 SPCPF 509


>UniRef50_D1QMM7 Pseudouridine synthase n=1 Tax=Prevotella oris F0302
           RepID=D1QMM7_9BACT
          Length = 522

 Score =  134 bits (337), Expect = 2e-30,   Method: Compositional matrix adjust.
 Identities = 85/210 (40%), Positives = 122/210 (58%), Gaps = 19/210 (9%)

Query: 17  LYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES---VHRLDMATSGVIVV 73
           +Y+D  I+VV KP+G+LSVPG+    +++V + +++ +P+A     VHRLDMATSG++VV
Sbjct: 325 IYEDKDIVVVCKPAGMLSVPGK--SLRENVRSLVRQRHPEATGPMIVHRLDMATSGLLVV 382

Query: 74  ALTKAAERELKRQFREREPKKQYVARVWG-HPSPAEGLVDLPLICDWPNRPKQKVCYETG 132
           AL   +  +L+RQF E   +K+YVA +   H     G + LPL  D  +RP+Q V    G
Sbjct: 383 ALNLKSYIDLQRQFEEHSVQKRYVALLSRPHHGARSGQISLPLRPDLYDRPRQIVDAVHG 442

Query: 133 KPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHML---ALGHPILGDRFYASPEARAM 189
           + A T Y+          R+ L P+TGR+HQLR+H      L +PI GD  Y + +    
Sbjct: 443 RKAVTNYQQT-----GENRMNLYPLTGRTHQLRMHCAHADGLNNPIKGDELYGTRDE--- 494

Query: 190 APRLLLHAEMLTITHPAYGNSMTFKAPADF 219
             RL LHAE L+  HP  G  M F+  ADF
Sbjct: 495 --RLYLHAEELSFVHPGTGKRMHFECHADF 522


>UniRef50_B8J173 Pseudouridine synthase, RluA family n=2 Tax=Desulfovibrio
           RepID=B8J173_DESDA
          Length = 525

 Score =  132 bits (331), Expect = 1e-29,   Method: Compositional matrix adjust.
 Identities = 91/224 (40%), Positives = 122/224 (54%), Gaps = 23/224 (10%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLL-----SVPGRLEEHKDSVMTRIQRDYPQAES---- 59
           P+E  L +L+QDDH++V NKP+GL      S P      + +++ R+   +PQ       
Sbjct: 75  PEEGHLELLWQDDHLVVCNKPAGLTVHPCPSCP------EQTLVQRLLGRFPQLSRLEGQ 128

Query: 60  ----VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPL 115
               VHRLD  TSG++VVALT+A    L   F ER+  K+Y+A V G P P EG    PL
Sbjct: 129 RPGIVHRLDKDTSGLLVVALTEADCLALAAAFAERQVHKEYLALVSGLP-PLEGQCREPL 187

Query: 116 ICDWPNRPKQKVCYET--GKPAQTEYEVVEYAADNTARVVLKPI-TGRSHQLRVHMLALG 172
                 + K  V  E   G+ A TE+  +    D +  ++   I TGR+HQ+RVHM  LG
Sbjct: 188 GRHPTAKIKMAVVPEDQGGRNAFTEWRRLWNTDDGSVSLLAVRIHTGRTHQIRVHMTHLG 247

Query: 173 HPILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
           +P+LGDR YA    + MAPR +LHA  L  THPA G  M F  P
Sbjct: 248 YPLLGDRLYAPKAVQNMAPRQMLHAWRLGFTHPASGEDMRFTCP 291


>UniRef50_C2HWY8 Pseudouridine synthase n=2 Tax=Vibrio cholerae RepID=C2HWY8_VIBCH
          Length = 177

 Score =  131 bits (329), Expect = 2e-29,   Method: Compositional matrix adjust.
 Identities = 62/118 (52%), Positives = 81/118 (68%)

Query: 1   MGMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESV 60
           M M  YNPP+EPW+ ++Y+D+HI+  NKPSGLLSVPGR  EH DS+  R+    P  + V
Sbjct: 1   MAMTEYNPPKEPWIDVIYEDEHIIAANKPSGLLSVPGRPVEHYDSMWARLVDYCPDVKVV 60

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICD 118
           HRLDM+TSG+I+ A  K  E  LK+QF+ R   K Y ARVWG     EG V+LP++C+
Sbjct: 61  HRLDMSTSGLILFAKGKHMESALKKQFQYRLTHKIYYARVWGVMEQDEGEVNLPIVCN 118


>UniRef50_D1XZI5 Pseudouridine synthase n=1 Tax=Prevotella bivia JCVIHMP010
           RepID=D1XZI5_9BACT
          Length = 577

 Score =  127 bits (319), Expect = 3e-28,   Method: Compositional matrix adjust.
 Identities = 84/212 (39%), Positives = 117/212 (55%), Gaps = 19/212 (8%)

Query: 16  ILYQDDHIMVVNKPSGLLSVPGR-LEEHKDSVMTRIQRDYPQAESVHRLDMATSGVIVVA 74
           IL++D+++ V++KP+GLLSVPG+ L     +++ +  +   +   VHRLDM TSG++VVA
Sbjct: 364 ILFEDNYLAVIDKPAGLLSVPGKKLATSVYALLKQKWQGRCKPYMVHRLDMDTSGLMVVA 423

Query: 75  LTKAAERELKRQFREREPKKQYVA----RVWGHPSPAEGLVDLPLICDWPNRPKQKVCYE 130
                  +L++QF  R   K+Y A     +     P +G + LPL  D  +RP+QKV  E
Sbjct: 424 KQAHVYHDLQQQFINRTVNKRYTAFLPLSLLDKNLPPKGKIILPLTADLFDRPRQKVDKE 483

Query: 131 TGKPAQTEYEVV------EYAADNTARVVLKPITGRSHQLRVHML---ALGHPILGDRFY 181
            GK A T YE+V      E       RV+L P TGR+HQLRVH      LG PI+GD  Y
Sbjct: 484 VGKIAITTYEIVGKTHYGERLKQLAVRVLLYPHTGRTHQLRVHCAHSEGLGTPIIGDNLY 543

Query: 182 ASPEARAMAPRLLLHAEMLTITHPAYGNSMTF 213
            +      A RL L+A+ L   HP     MTF
Sbjct: 544 GNK-----ANRLHLYADRLRFVHPITHKEMTF 570


>UniRef50_Q82WZ5 Ribosomal large subunit pseudouridine synthase D n=2
           Tax=Nitrosomonas RepID=RLUD_NITEU
          Length = 344

 Score =  127 bits (318), Expect = 3e-28,   Method: Compositional matrix adjust.
 Identities = 79/216 (36%), Positives = 122/216 (56%), Gaps = 17/216 (7%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR-----DYPQAESVHRLDMATS 68
           L IL++DDH+++++KP+GL+  PG    H   +   +         P+A  VHRLD  T+
Sbjct: 109 LKILFEDDHLIIIDKPAGLVVHPGNGNWHGTLLNALLNHAPQLSQVPRAGIVHRLDKDTT 168

Query: 69  GVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVC 128
           G++VVA T  A+ +L RQ ++R  K+ Y+A V G     +G+VD P I   P    +   
Sbjct: 169 GLLVVAKTIEAQFDLARQLQQRTVKRHYLALVLGKLE-KDGVVDAP-IGRHPIHRTRMAV 226

Query: 129 YETGKPAQTEYEVVE-YAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFY------ 181
            + GKPA+T Y V+E + A       L+  TGR+HQ+RVH+L++GHP+ GD  Y      
Sbjct: 227 VQNGKPARTHYRVLEKFTASTLLHCSLE--TGRTHQIRVHLLSIGHPLAGDPVYGRTSPD 284

Query: 182 -ASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
            ++ +A    PR  LHA  L +THP  G  + +++P
Sbjct: 285 PSTADAVVRLPRQALHAWQLELTHPHSGQILLWESP 320


>UniRef50_C7LWM1 Pseudouridine synthase, RluA family n=1 Tax=Desulfomicrobium
           baculatum DSM 4028 RepID=C7LWM1_DESBD
          Length = 526

 Score =  126 bits (316), Expect = 5e-28,   Method: Compositional matrix adjust.
 Identities = 82/217 (37%), Positives = 121/217 (55%), Gaps = 11/217 (5%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES--------V 60
           P +  L + + D+ ++VVNK   +   P      + +++ R+   +P   S        V
Sbjct: 77  PDDGPLNVFFADEDLVVVNKTPAMTVHPAP-SVAEPTLVHRVAHHFPALLSQSGERPGIV 135

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLD  TSG+IV+AL+++A   L + F  RE  K+Y+A V G P  + G V L L     
Sbjct: 136 HRLDKDTSGLIVLALSESARLSLTQAFASREVYKEYLALVAGVPD-SSGTVSLALGRHPS 194

Query: 121 NRPKQKVCYETGKPAQTEYEVVEYAADNTARVV-LKPITGRSHQLRVHMLALGHPILGDR 179
            + +  V    G+ A+T +E++  AAD +A +V ++ +TGR+HQ+RVHM ALGHP+LGD 
Sbjct: 195 IKTRMAVVERGGRAAETRFELLWSAADRSASLVRVRIMTGRTHQIRVHMAALGHPLLGDA 254

Query: 180 FYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
            YA  +  A APR +LHA  L   HP    SM F AP
Sbjct: 255 VYADKQTAARAPRQMLHAWQLRFEHPRSFESMEFCAP 291


>UniRef50_B8CCD9 Predicted protein (Fragment) n=2 Tax=Thalassiosira pseudonana
           RepID=B8CCD9_THAPS
          Length = 337

 Score =  126 bits (316), Expect = 6e-28,   Method: Compositional matrix adjust.
 Identities = 82/249 (32%), Positives = 128/249 (51%), Gaps = 46/249 (18%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES-------VHRLDMA 66
           L ++Y+D+HI+V+NKPSG+L+VPG+     +  + ++  +    ES       VHRL M 
Sbjct: 92  LDVVYEDEHIVVINKPSGVLTVPGK---DDNPSLNKVVFERFGCESNRMDKMVVHRLGMD 148

Query: 67  TSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDW------P 120
           TSG++V A T +A REL   FR R+  ++Y A V GH +   G +DL L+ D+       
Sbjct: 149 TSGLVVFARTNSALRELNSLFRTRKVTRKYEALVCGHLAKDSGDIDLSLMRDYEALIGLD 208

Query: 121 NRPKQKVCYETGKPAQTEYEVV---EYAADNTARVVLKPITGRSHQLRVHMLALGHPILG 177
           +    K   E+ K + T++EV+   E       R+ L  I+GR+HQL VH  A+GHPI+G
Sbjct: 209 SGEVGKKLLESPKESMTKFEVISKEEMNGKKVTRIALTSISGRTHQLNVHCAAIGHPIVG 268

Query: 178 DRFY-----ASPE---------------------ARAMAPR-LLLHAEMLTITHPAYGNS 210
           D  Y     A+P                      A A+A + + +HA+ ++  HP    +
Sbjct: 269 DTVYGFGGEAAPNGGLEESDLPEDRASEALQKDIAEAVAGKPMCVHAKSISFDHPVTKEA 328

Query: 211 MTFKAPADF 219
           ++F   A F
Sbjct: 329 LSFDCAAPF 337


>UniRef50_C4XSN0 Ribosomal large subunit pseudouridine synthase D/dephospho-CoA
           kinase n=1 Tax=Desulfovibrio magneticus RS-1
           RepID=C4XSN0_DESMR
          Length = 554

 Score =  125 bits (315), Expect = 7e-28,   Method: Compositional matrix adjust.
 Identities = 81/228 (35%), Positives = 126/228 (55%), Gaps = 24/228 (10%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES--------VHRLDM 65
           L +LY D  ++V+NKP+GL   P    +   +++ R+   +P   +        VHRLD 
Sbjct: 93  LKLLYLDGDVLVLNKPAGLTIHPAS-SQPDGTLVNRLLHHFPDMRAMAGDRPGIVHRLDK 151

Query: 66  ATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQ 125
            TSG+++VA T++A   L   F ER   K Y+A V G P  ++G+++LP+  D  +  K 
Sbjct: 152 DTSGLLLVAQTESARLALAADFAERRVAKTYLALVHGRPERSDGVIELPVGRDPKHPTKM 211

Query: 126 KVCYETGKPAQTEYEVVEYAADNTARVVLKPI-TGRSHQLRVHMLALGHPILGDRFYASP 184
            V  + G+ A++ +++   A D TA ++   I TGR+HQ+RVHM A+GHPI+GD  Y + 
Sbjct: 212 AVVAKGGREAKSSWKLAWTAPDGTASLLEVAIATGRTHQIRVHMAAMGHPIVGDAVYGAR 271

Query: 185 E-----------ARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
           +           AR +A R +LHA  L  +HP  G  ++F    PADF
Sbjct: 272 QHSDWTRRGGAMAR-LAKRQMLHAWKLAFSHPGTGEELSFCQPPPADF 318


>UniRef50_Q1MQ60 Pseudouridylate synthases, 23S RNA-specific n=1 Tax=Lawsonia
           intracellularis PHE/MN1-00 RepID=Q1MQ60_LAWIP
          Length = 541

 Score =  125 bits (314), Expect = 9e-28,   Method: Compositional matrix adjust.
 Identities = 79/222 (35%), Positives = 121/222 (54%), Gaps = 20/222 (9%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES--------V 60
           P+E +L IL+ D+H+ ++NKP GL   P      + +++ R+ + +P+           V
Sbjct: 78  PEEGFLEILFSDEHLAIINKPPGLTVHPAP-SCQESTLVHRLLKYFPKLIEQGGLRPGIV 136

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HR+D  TSG++ +ALT+    +L + F +R+  K+Y+A V G PS  EG + +PL  D  
Sbjct: 137 HRIDKDTSGLLCIALTEDTRLKLSKIFLDRKINKEYLALVHGVPS-MEGYIAVPLGRD-- 193

Query: 121 NRPKQKVCYET---GKPAQTEYEVVEYAADNTARVVLKPI-TGRSHQLRVHMLALGHPIL 176
             PK KV       GKPA TE+ V+    ++   ++   I TGR+HQ+RVHM  +GHP++
Sbjct: 194 --PKTKVKVAVNPKGKPAHTEWRVLHRGKNDVYSILALTIQTGRTHQIRVHMKHIGHPLV 251

Query: 177 GDRFYASPEARAM--APRLLLHAEMLTITHPAYGNSMTFKAP 216
           GD+ YA           R +LHA  L+  HP  G  M F  P
Sbjct: 252 GDKLYAGGHVNKTFQCNRQMLHAWKLSFEHPITGKKMNFLCP 293


>UniRef50_UPI00016B2413 ribosomal large subunit pseudouridine synthase, RluD subfamily
           protein n=3 Tax=candidate division TM7
           RepID=UPI00016B2413
          Length = 379

 Score =  125 bits (314), Expect = 1e-27,   Method: Compositional matrix adjust.
 Identities = 81/207 (39%), Positives = 113/207 (54%), Gaps = 13/207 (6%)

Query: 17  LYQDDHIMVVNKPSGLLS-VPGRLEEHKDSV-----MTRIQRDYPQAESVHRLDMATSGV 70
           +Y+D+ I+V+NKP+G+L+   G + E   +      +T  + D  +   +HRLD  TSGV
Sbjct: 177 IYEDNDIIVINKPAGMLTHAKGAIAEEFTAADIVKPITNYKADTNRPGIIHRLDRNTSGV 236

Query: 71  IVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYE 130
           +++     A  ++++QF +R  KK Y A V G P   + L+DLP I   P+RP       
Sbjct: 237 LLMVKNSDAASKIQKQFSQRTVKKTYYAIVCGIPYQHKALIDLP-IERNPSRPSTFRVGV 295

Query: 131 TGKPAQTEYEVV-EYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARAM 189
            GK AQT YEV       N + + L+P TGR+HQLRVHM  L  PILGD  Y    A   
Sbjct: 296 NGKSAQTSYEVERSIIKKNISLIKLQPKTGRTHQLRVHMQYLNTPILGDLVYGGKPAE-- 353

Query: 190 APRLLLHAEMLTITHPAYGNSMTFKAP 216
             R+ LHAE L +T  + G    FKAP
Sbjct: 354 --RMFLHAESLEVTLLS-GERKVFKAP 377


>UniRef50_Q0BUM2 Pseudouridine synthase n=12 Tax=Acetobacteraceae RepID=Q0BUM2_GRABC
          Length = 366

 Score =  125 bits (313), Expect = 1e-27,   Method: Compositional matrix adjust.
 Identities = 89/218 (40%), Positives = 116/218 (53%), Gaps = 25/218 (11%)

Query: 11  EPWLVILYQDDHIMVVNKPSGLLSVPG-RLEEHKDSVMT--RIQRDYPQAESVHRLDMAT 67
           E W  ILY+DDH++V+NKPSGL S  G  +  H D ++   R  RD  +   VHRLD  T
Sbjct: 122 ESW--ILYKDDHLIVLNKPSGLPSQGGPGITRHLDGLLDGLRFGRD-DRPRLVHRLDRDT 178

Query: 68  SGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKV 127
           SGVIV+A +     +L   FR RE +K Y A V G P P EG +D PL+    N   + V
Sbjct: 179 SGVIVIARSPGVAAKLAALFRTRETEKVYWAVVAGRPVPVEGRIDRPLLRQ--NDRNEPV 236

Query: 128 CYETGK-----PAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYA 182
                K      A T+Y  +++AA   A + L+P+TGR HQLRVH  A+  PILGD  Y 
Sbjct: 237 VLADRKDRDKVTAITDYRTLDHAARKLAWLELRPLTGRMHQLRVHCAAMDAPILGDERYG 296

Query: 183 S------------PEARAMAPRLLLHAEMLTITHPAYG 208
           S                 ++ RL LHA  L++ HPA G
Sbjct: 297 SWRNTDERGVRNTALVEGLSRRLHLHARRLSLPHPAGG 334


>UniRef50_Q2RQY9 Pseudouridine synthase n=3 Tax=Alphaproteobacteria
           RepID=Q2RQY9_RHORT
          Length = 330

 Score =  124 bits (312), Expect = 2e-27,   Method: Compositional matrix adjust.
 Identities = 82/200 (41%), Positives = 108/200 (54%), Gaps = 6/200 (3%)

Query: 15  VILYQDDHIMVVNKPSGLLSVPGR-LEEHKDSVMTRIQRDYPQAESVHRLDMATSGVIVV 73
            IL++D H++V+NK +GL    G     H D ++  +         VHRLD  TSGV+V+
Sbjct: 95  AILHEDAHLIVINKEAGLAVQGGTGTPHHLDGMLESLADGGETPRLVHRLDKDTSGVLVL 154

Query: 74  ALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQ-KVCYETG 132
           A T+AA R L   FR RE  K Y A V G P   +G +   L      R ++ ++  E G
Sbjct: 155 ARTQAAARALTSAFRSREALKVYWAIVVGRPPMLQGTIKGALAKVAGGRGERMEINEEEG 214

Query: 133 KPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASP----EARA 188
           K A T++ VV+ AA   A V L P TGR+HQLRVH L +G PILGD  Y  P    E   
Sbjct: 215 KRAVTDFRVVDQAAKACAWVELHPRTGRTHQLRVHCLEMGTPILGDGKYGGPGAFLEGTE 274

Query: 189 MAPRLLLHAEMLTITHPAYG 208
           +  R+ LHA  L + HPA G
Sbjct: 275 LPKRMHLHARALALPHPAGG 294


>UniRef50_C1ZGS9 Pseudouridine synthase n=1 Tax=Planctomyces limnophilus DSM 3776
           RepID=C1ZGS9_PLALI
          Length = 345

 Score =  124 bits (312), Expect = 2e-27,   Method: Compositional matrix adjust.
 Identities = 90/240 (37%), Positives = 121/240 (50%), Gaps = 32/240 (13%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGR----------LEEHKDSVMTRIQRDYPQAE 58
           P++  L ILY D+++ V+NK + ++  PGR          L+ H DS ++ +   Y +A 
Sbjct: 86  PEDIPLDILYDDEYLCVINKTANMIVHPGRGNYRGTLAGALQFHFDS-LSDVAGQY-RAG 143

Query: 59  SVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICD 118
            VHRLD  TSGV+VVA      + L RQF ER  +K+Y A VWG        V+  +   
Sbjct: 144 IVHRLDRDTSGVLVVAKDNTVHQHLSRQFEERSVEKEYHAIVWGEMQFDADYVETYVRVS 203

Query: 119 WPNRPKQKVC--YETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPIL 176
           + NR +  VC   +  + A T YEV +     T  V L+P TGR+HQLRVHM  LGHPI+
Sbjct: 204 FRNRERMMVCPPGDNARQAATFYEVQQRFRGFTY-VKLQPQTGRTHQLRVHMHHLGHPII 262

Query: 177 GDRFY-------------ASPEA--RAMAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
            DR Y              +PE     +  R  LHA  L   HP     M F+A  PADF
Sbjct: 263 ADRLYEGKTCVKLSDILPETPEEADETLIDRQALHARRLAFNHPVTKKRMVFEAPLPADF 322


>UniRef50_B4UM41 Pseudouridine synthase, RluA family n=4 Tax=Anaeromyxobacter
           RepID=B4UM41_ANASK
          Length = 302

 Score =  123 bits (309), Expect = 4e-27,   Method: Compositional matrix adjust.
 Identities = 87/214 (40%), Positives = 110/214 (51%), Gaps = 18/214 (8%)

Query: 16  ILYQDDHIMVVNKPSGLLSVP------GRLEEHKDSVMTRIQRDYPQAESVHRLDMATSG 69
           +LY D  +  V+KP+G+ + P      G L E   +++            VHRLD  TSG
Sbjct: 83  LLYADADLCAVDKPAGVPAQPTLTTDRGALPELVSALLG------APVTLVHRLDRETSG 136

Query: 70  VIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCY 129
           V V A T+ A   L   FR   P+K Y+A     PSPAEG V L L  D P RP  +   
Sbjct: 137 VTVFARTRDAAAALAEAFRTGTPEKTYLALCARAPSPAEGRVALALGKD-PARPGLRRVD 195

Query: 130 ETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPE--AR 187
             G PA T Y  +  A    ARV  +P TGR+HQ+RVH+ ALG P+LGD  Y  P     
Sbjct: 196 PAGDPAATRYRTLREAPGG-ARVEARPETGRTHQIRVHLAALGAPLLGDARYGGPRRVGE 254

Query: 188 AMAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
              PR++LHA  L + HPA G  M F+A  P DF
Sbjct: 255 VAVPRVMLHATRLELPHPATGARMVFEAEPPEDF 288


>UniRef50_Q1ILA4 Pseudouridine synthase n=1 Tax=Candidatus Koribacter versatilis
           Ellin345 RepID=Q1ILA4_ACIBL
          Length = 333

 Score =  122 bits (305), Expect = 1e-26,   Method: Compositional matrix adjust.
 Identities = 86/240 (35%), Positives = 122/240 (50%), Gaps = 31/240 (12%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLS--VPGRLEEHKDS---VMTRIQRDYPQAES---- 59
           P++  L ++Y+DD + V+NKP+G++     G  EE ++    V   + R    +E     
Sbjct: 77  PEDIPLDVVYEDDDLAVINKPAGMMVHVGAGATEEERNRGTLVNALLYRFRALSEVGGDM 136

Query: 60  ----VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPL 115
               VHRLD  TSG+IVVA    A R+L  QF  R   K+YVA V G P   +G ++LP+
Sbjct: 137 RPGIVHRLDKETSGLIVVAKNDVAHRKLAEQFSSRRVHKKYVALVHGWPKKLKGTINLPI 196

Query: 116 ICDWPNRPKQKVCYETGKPAQTEYEV---VEYAADNTARVVLKPITGRSHQLRVHMLALG 172
             D   R +       G+ A + YEV   +E      A V +K  TGR+HQ+RVHM +LG
Sbjct: 197 ARDMSRRTRMTTRGSGGRDALSHYEVKEKIESPYGKFALVEVKIETGRTHQIRVHMASLG 256

Query: 173 HPILGDRFYASP-EAR------------AMAPRLLLHAEMLTITHPAYGNSMTF--KAPA 217
           HP++GD  Y +P E R            A   R  LHA  + +  PA G ++ F  K PA
Sbjct: 257 HPVVGDTLYGAPGELRVTKALKGMPSKMASLERNFLHAAEIELQQPATGKALRFVTKVPA 316


>UniRef50_A6C0W7 Pseudouridine synthase n=1 Tax=Planctomyces maris DSM 8797
           RepID=A6C0W7_9PLAN
          Length = 342

 Score =  122 bits (305), Expect = 1e-26,   Method: Compositional matrix adjust.
 Identities = 88/245 (35%), Positives = 121/245 (49%), Gaps = 36/245 (14%)

Query: 4   ENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESV--- 60
           +N  PP++  + I+Y+DD I ++NKPS ++  PG+   +  ++   +Q  + Q   V   
Sbjct: 83  DNRLPPEDIPIDIVYEDDWIAIINKPSDMIVHPGK-GNYAGTLAGALQYHFDQLSDVAGQ 141

Query: 61  ------HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLP 114
                 HRLD  TSG++VVA       +L  QF +R+ +K+Y A VWG        +D  
Sbjct: 142 YRPGIVHRLDRNTSGIMVVAKDNQVHAKLSAQFEKRDVQKEYRAIVWGRMEFDTDYID-T 200

Query: 115 LICDWPN-RPKQKVCYETG--KPAQTEYEVVE-YAADNTARVVLKPITGRSHQLRVHMLA 170
            +C  P  R K  VC E G  + A T YEV+E Y A    R  LKP TGR+HQLRVHM  
Sbjct: 201 FMCVHPRAREKMIVCDEGGNARNAFTYYEVIERYQAFTYVR--LKPRTGRTHQLRVHMQH 258

Query: 171 LGHPILGDRFY-------------------ASPEARAMAPRLLLHAEMLTITHPAYGNSM 211
           +GH I+ DR Y                   A  E+  +  R  LHA  L   HP  G  M
Sbjct: 259 IGHSIVADRVYGGHKSLKMKSLGIQAEADAAELESDVLIERQALHAYCLEFFHPQSGKPM 318

Query: 212 TFKAP 216
            F+AP
Sbjct: 319 KFEAP 323


>UniRef50_D0XS67 Pseudouridine synthase n=1 Tax=Brevundimonas subvibrioides ATCC
           15264 RepID=D0XS67_9CAUL
          Length = 350

 Score =  122 bits (305), Expect = 1e-26,   Method: Compositional matrix adjust.
 Identities = 77/213 (36%), Positives = 116/213 (54%), Gaps = 16/213 (7%)

Query: 15  VILYQDDHIMVVNKPSGLLSVPG-RLEEHKDSVMTRIQRDYPQAESVHRLDMATSGVIVV 73
           +++Y+DD ++ +NKP GL    G +   H D +++       +   VHRLD  TSGV+++
Sbjct: 112 MVIYEDDLVIALNKPWGLAVQGGTKTTRHVDRLLSAWGEGMERPRLVHRLDRDTSGVLLL 171

Query: 74  ALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPL----ICDW----PNRPKQ 125
                A + L   F  R+ KK Y A V G P PA+G + + L    I D+    P  PK 
Sbjct: 172 GKGPEAAKRLAGAFARRQAKKTYWAIVMGLPKPADGQISVHLKKSGINDYEIMRPADPKD 231

Query: 126 KVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPE 185
                  +PA+T Y V+ +AA   + + L+P TGR+HQLR HM A+GHPILGD  Y    
Sbjct: 232 PGA----EPAETAYAVISHAAQRASWMALRPFTGRTHQLRAHMKAIGHPILGDPKYGDDA 287

Query: 186 ARAMAP--RLLLHAEMLTITHPAYGNSMTFKAP 216
           +  ++   +L LHA  + + HPA G ++  +AP
Sbjct: 288 STQLSGPLKLQLHARRIELDHPA-GGTLVVEAP 319


>UniRef50_C0QAZ3 RluD1 n=1 Tax=Desulfobacterium autotrophicum HRM2
           RepID=C0QAZ3_DESAH
          Length = 313

 Score =  121 bits (303), Expect = 2e-26,   Method: Compositional matrix adjust.
 Identities = 81/216 (37%), Positives = 117/216 (54%), Gaps = 16/216 (7%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP-----------QAESVHR 62
           L  L++D  I+VVNKP+G++  PG       +++  +   +P           +   VHR
Sbjct: 81  LDFLHEDQWIVVVNKPAGMVVHPG-AGNSSGTLLNALLHHFPSLTDTHCDPPLRGGIVHR 139

Query: 63  LDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNR 122
           LD  TSG IVVA +K A   L+++FR R  +K+Y+A   G  +  +G + LP+     +R
Sbjct: 140 LDKDTSGTIVVAKSKKAYEFLQKEFRFRRVEKRYIALATGIITETQGRITLPIGRHPIHR 199

Query: 123 PKQKVCYETGKPAQTEYEVVEYAADNT-ARVVLKPITGRSHQLRVHMLALGHPILGDRFY 181
            +  V  E  +PA+T + V+   A +T   V LK  TGR+HQ+RVH  ALGHP+ GDR Y
Sbjct: 200 KRMAVNTERARPAETLWRVLGQMAGHTLLDVGLK--TGRTHQIRVHFRALGHPLAGDRVY 257

Query: 182 A-SPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
               +  A APR +LHA  L   HP  G  + F AP
Sbjct: 258 GFRGKQSARAPRQMLHAGTLGFRHPWSGKRVEFTAP 293


>UniRef50_Q9KQH0 Ribosomal large subunit pseudouridine synthase C n=59
           Tax=Proteobacteria RepID=RLUC_VIBCH
          Length = 315

 Score =  121 bits (303), Expect = 2e-26,   Method: Compositional matrix adjust.
 Identities = 78/211 (36%), Positives = 119/211 (56%), Gaps = 13/211 (6%)

Query: 16  ILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQA---ESVHRLDMATSGVIV 72
           I+Y+DDH++++NKPSG  +V G    H  ++   ++   PQA   E VHR+D  TSG+++
Sbjct: 97  IVYEDDHLLILNKPSGT-AVHGGSGLHFGAIEA-LRALRPQARFLELVHRIDRDTSGILL 154

Query: 73  VALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYETG 132
           VA  ++A R L+ QFRE+  +K Y A V GH      +V+ PL+ +  N   +      G
Sbjct: 155 VAKKRSALRHLQAQFREKTVQKYYYALVMGHWDAECKVVNAPLLKNEVNSIVR--VNPNG 212

Query: 133 KPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPI-----LGDRFYASPEAR 187
           KP++T + ++E  A+ T  V   P+TGR+HQ+RVH   +GHPI      GDR + +  A+
Sbjct: 213 KPSETRFRILEKFAEATL-VQASPVTGRTHQIRVHTQYMGHPIAWDDRYGDRRFDAYTAQ 271

Query: 188 AMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
               RL LHA  +   HPA    +   AP +
Sbjct: 272 FGIERLFLHAANIQFVHPASEKKLEIHAPLE 302


>UniRef50_Q8ZQ16 Ribosomal large subunit pseudouridine synthase C n=110
           Tax=Gammaproteobacteria RepID=RLUC_SALTY
          Length = 319

 Score =  121 bits (303), Expect = 2e-26,   Method: Compositional matrix adjust.
 Identities = 85/215 (39%), Positives = 112/215 (52%), Gaps = 14/215 (6%)

Query: 15  VILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQA---ESVHRLDMATSGVI 71
           VILY+DDHI+V+NKPSG     G        V+  ++   P+A   E VHRLD  TSGV+
Sbjct: 94  VILYEDDHILVLNKPSGTAVHGG--SGLSFGVIEGLRALRPEARFLELVHRLDRDTSGVL 151

Query: 72  VVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKV-CYE 130
           +VA  ++A R L  Q RE+  +K Y+A V G        V  PL+ +     ++ V   +
Sbjct: 152 LVAKKRSALRSLHEQLREKGMQKDYLALVRGQWQSHVKTVQAPLLKNILQSGERIVRVSQ 211

Query: 131 TGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYAS------- 183
            GKP++T ++V E  A  T  V   P+TGR+HQ+RVH    GHPI  D  Y         
Sbjct: 212 EGKPSETRFKVEERYAFATL-VRCSPVTGRTHQIRVHTQYAGHPIAFDDRYGDREFDQQL 270

Query: 184 PEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
            EA     RL LHA  L  THP  G  M  +AP D
Sbjct: 271 TEAGTGLKRLFLHAAALKFTHPGTGEVMRIEAPMD 305


>UniRef50_B2UL66 Pseudouridine synthase n=2 Tax=Verrucomicrobiaceae
           RepID=B2UL66_AKKM8
          Length = 323

 Score =  121 bits (303), Expect = 2e-26,   Method: Compositional matrix adjust.
 Identities = 82/219 (37%), Positives = 115/219 (52%), Gaps = 11/219 (5%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYPQAESV 60
           PQ+  L ILY+D+ ++V+NK SG++  P         V   +             +   V
Sbjct: 72  PQDIPLDILYEDEDVVVINKESGMVVHPAAGNPDGTIVNALLHHCGDLSGIGGVERPGIV 131

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLD  TSG +V+A    A + L  QF  R  +K+Y+A V G PS + G V   +     
Sbjct: 132 HRLDKDTSGCLVIAKNDGAHQSLTAQFAARSTEKRYLAVVQGIPSQSSGTVFTHIGRHPV 191

Query: 121 NRPKQKVCY-ETGKPAQTEYEVVEYAADNTARVVLKPI-TGRSHQLRVHMLALGHPILGD 178
           NR K  V    +GK A T+Y+++       + +VL  + TGR+HQ+RVHML LGHP++GD
Sbjct: 192 NRLKMAVVNPGSGKAAITDYDLLCADPSTDSSLVLCTLHTGRTHQIRVHMLYLGHPLIGD 251

Query: 179 RFYASPEARAMAP-RLLLHAEMLTITHPAYGNSMTFKAP 216
             YA P  +   P RL+LHA  L   HP  G  M F+AP
Sbjct: 252 PIYAKPARQKAKPGRLMLHAWRLGFDHPRTGKRMDFEAP 290


>UniRef50_Q1DCE5 Pseudouridine synthase, RluA family n=2 Tax=Cystobacterineae
           RepID=Q1DCE5_MYXXD
          Length = 310

 Score =  120 bits (301), Expect = 3e-26,   Method: Compositional matrix adjust.
 Identities = 89/216 (41%), Positives = 115/216 (53%), Gaps = 15/216 (6%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVP--GRLEEH-KDSVMTRIQRDYPQAESVHRLDM 65
           P  P L +LY+D  ++ V+KP+G+ + P  GR+ +   D V  ++ R    A  VHRLD 
Sbjct: 77  PPAPELRVLYEDADVIAVDKPAGVSAQPTEGRVGDSLVDLVGAKLGR---PAGLVHRLDR 133

Query: 66  ATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQ 125
            TSGV V   T  A   L  +FRE   +K+YVA   G   P  G VDLPL  D P+RP +
Sbjct: 134 ETSGVTVFGKTAEATSALAAEFREGRARKRYVA-ATGPGLPPSGTVDLPLSKD-PSRPGR 191

Query: 126 --KVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYAS 183
                   G PA T++  +         V L P TGR+HQLR H+ ALG PILGD  Y  
Sbjct: 192 WRATRAANGVPALTDFHTLSSGPAFCV-VELLPHTGRTHQLRAHLTALGAPILGDARYGG 250

Query: 184 PEARA---MAPRLLLHAEMLTITHPAYGNSMTFKAP 216
             ARA    APR LLHA+ L + HP  G  +  +AP
Sbjct: 251 -AARAEGVEAPRCLLHAQALELGHPRTGKLLRIEAP 285


>UniRef50_C6J6E3 Pseudouridine synthase n=2 Tax=Bacillales RepID=C6J6E3_9BACL
          Length = 321

 Score =  120 bits (301), Expect = 3e-26,   Method: Compositional matrix adjust.
 Identities = 79/221 (35%), Positives = 114/221 (51%), Gaps = 25/221 (11%)

Query: 16  ILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES-------VHRLDMATS 68
           I+Y+D+ +++VNK +GL+  P     H    +      Y Q +        VHRLD  TS
Sbjct: 87  IVYEDEALLIVNKAAGLIVHP--THGHYTGTLANGVVYYWQEKGEKFRFRPVHRLDQETS 144

Query: 69  GVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVC 128
           G+I +A      + +  Q    E  K+Y A V G P+  EG +D P+  D P  P +++ 
Sbjct: 145 GLIAIAKNAYVHQHISEQLIAGEVTKKYTALVHGCPAVPEGTIDGPIDRD-PAEPHRRIV 203

Query: 129 YETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPE--- 185
             +G P+ T Y+V E   D  ARV L+  TGR+HQ+RVHM ++GHP++GD+FY  P    
Sbjct: 204 TPSGYPSLTYYKVAEAYGDG-ARVELRLGTGRTHQIRVHMTSIGHPLIGDKFYGMPGLAE 262

Query: 186 ----ARAMAPRL-------LLHAEMLTITHPAYGNSMTFKA 215
               AR    RL        LHA  L   HP  G ++TFK+
Sbjct: 263 LPAPARERIARLDAAIGRQALHASELGFRHPLTGEALTFKS 303


>UniRef50_Q0IBH1 Pseudouridine synthase n=11 Tax=Cyanobacteria RepID=Q0IBH1_SYNS3
          Length = 220

 Score =  120 bits (300), Expect = 4e-26,   Method: Compositional matrix adjust.
 Identities = 75/193 (38%), Positives = 104/193 (53%), Gaps = 2/193 (1%)

Query: 23  IMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDMATSGVIVVALTKAAERE 82
            +VV KPSGLLS PG  +   DS++TR+Q   P+   VHRLD  TSG++++A    + + 
Sbjct: 25  FLVVEKPSGLLSQPGLGDSQSDSLITRLQAVRPELRLVHRLDRDTSGLLLLARDPESLKV 84

Query: 83  LKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYETGKPAQTEYEVV 142
           L   F ER+  K Y A V GHP    G V LPL       P +      G+   T +   
Sbjct: 85  LGGLFAERKVHKFYAADVHGHPKSRSGAVRLPL-ARLSAHPPRYGPRRDGRSCLTLWRCA 143

Query: 143 EYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARAMAPRLLLHAEMLTI 202
           +  +D + R+ L P TGRSHQLR H+ A+G PI+GD  YAS    +   RL LHA  L+ 
Sbjct: 144 QMGSDRS-RLWLAPRTGRSHQLRAHLAAIGLPIIGDPIYASSGLGSPGERLHLHALGLSF 202

Query: 203 THPAYGNSMTFKA 215
           + P  G  +  ++
Sbjct: 203 SDPFSGQRIRVRS 215


>UniRef50_B8CWM0 Pseudouridine synthase n=1 Tax=Halothermothrix orenii H 168
           RepID=B8CWM0_HALOH
          Length = 308

 Score =  120 bits (300), Expect = 5e-26,   Method: Compositional matrix adjust.
 Identities = 83/224 (37%), Positives = 118/224 (52%), Gaps = 17/224 (7%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLS--VPGRLEE--------HKDSVMTRIQRDYPQAE 58
           P E  L I+Y+D  I+V+NK +GL+    PG  E         + D++ T    + P   
Sbjct: 77  PVEMDLDIIYEDKDILVLNKNAGLVVHPAPGNHENTLVNALIAYCDNLSTISGVNRPGI- 135

Query: 59  SVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICD 118
            VHRLD  TSGV+V+A    + R+L  QF++R+ KK Y   + G     EG +D P+  D
Sbjct: 136 -VHRLDKDTSGVMVIAKNDISHRKLVEQFKQRKTKKYYRTLLKGELPYKEGKIDAPIGRD 194

Query: 119 WPNRPKQKVCYETGKPAQTEYEVVEYAADNT-ARVVLKPITGRSHQLRVHMLALGHPILG 177
             +R K  V  +  K A T ++V+E+  D++   V LK  TGR+HQ+RVH   +G P++G
Sbjct: 195 PHDRKKMAVTRKNSKKAVTYFKVLEFFRDHSYVEVELK--TGRTHQIRVHFSYMGFPVVG 252

Query: 178 DRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
           D  Y     R  A R LLHA  L   HP     + +KA  P DF
Sbjct: 253 DSIYGKKRNRLQATRQLLHAYRLGFYHPRNDKWVEYKASLPDDF 296


>UniRef50_Q8XYX8 Ribosomal large subunit pseudouridine synthase D n=94
           Tax=Proteobacteria RepID=RLUD_RALSO
          Length = 358

 Score =  119 bits (299), Expect = 6e-26,   Method: Compositional matrix adjust.
 Identities = 82/223 (36%), Positives = 120/223 (53%), Gaps = 23/223 (10%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES------VHRLDMAT 67
           L ++Y+DD ++V+NKP+GL+  P        +V+  +   YPQA        VHRLD  T
Sbjct: 116 LDVVYEDDTLLVINKPAGLVVHPA-AGNWSGTVLNGLLHRYPQAAGLPRAGIVHRLDKET 174

Query: 68  SGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKV 127
           SG++VVA T  A+ +L RQ + R  K+ Y+A VWG  +P  G +D P+  D  +R +  +
Sbjct: 175 SGLMVVARTLPAQTDLVRQLQARTVKRTYLALVWGE-TPEAGTIDAPIGRDPRDRTRMAI 233

Query: 128 C-YETGKPAQTEYEVVEYAADNTARVVLKPI---TGRSHQLRVHMLALGHPILGDRFYAS 183
               +GKPA+T ++ ++      A+V L      TGR+HQ+RVH  + GHP+LGD  Y  
Sbjct: 234 IETASGKPARTHFKTLDVVDLGRAQVSLVQCQLETGRTHQIRVHFESEGHPLLGDPVYTR 293

Query: 184 PEARA-----MAP------RLLLHAEMLTITHPAYGNSMTFKA 215
              R       AP      R  LHA  L + HPA G S+ + A
Sbjct: 294 NFRRGRPQTIKAPLPAPFARQALHAVRLGLVHPASGQSVHWHA 336


>UniRef50_Q3ABZ7 Pseudouridine synthase n=2 Tax=Bacteria RepID=Q3ABZ7_CARHZ
          Length = 305

 Score =  119 bits (298), Expect = 7e-26,   Method: Compositional matrix adjust.
 Identities = 77/218 (35%), Positives = 112/218 (51%), Gaps = 13/218 (5%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES--------- 59
           P+E  L I+Y+D+ ++VVNK +G++  P   E + D  +      + Q  S         
Sbjct: 77  PEEIPLDIVYEDEDLVVVNKKAGMVVHPA--EGNWDGTLVNALLYHCQNLSGIGGVLRPG 134

Query: 60  -VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICD 118
            VHRLD  TSG++VVA    A + L  Q +E++  ++Y   V G+    EG++DLP I  
Sbjct: 135 IVHRLDKDTSGLLVVAKNDLAHQSLAEQIKEKKAVREYWTIVHGYLKNKEGIIDLP-IGR 193

Query: 119 WPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGD 178
            P   ++      GK AQT Y+V+E        +  K +TGR+HQ+RVH   LGHP+LGD
Sbjct: 194 HPRDRQKMAVVSNGKTAQTVYKVLEEFNKGFTLIQAKLLTGRTHQIRVHFSYLGHPVLGD 253

Query: 179 RFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
             Y          R +LHA  L+  HP  G  + F AP
Sbjct: 254 PKYGHQNNPFGVKRQMLHAIKLSFIHPRSGELLEFTAP 291


>UniRef50_A0L9J0 Pseudouridine synthase n=1 Tax=Magnetococcus sp. MC-1
           RepID=A0L9J0_MAGSM
          Length = 332

 Score =  119 bits (297), Expect = 9e-26,   Method: Compositional matrix adjust.
 Identities = 84/243 (34%), Positives = 120/243 (49%), Gaps = 36/243 (14%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR----DYPQAE------ 58
           P+E  L IL++D+H++V+NKP+G++  PG    H   V   +      D P         
Sbjct: 82  PEEIALEILFEDEHLIVLNKPAGMVVHPGAGVNHGTLVNALLYHCGTPDNPHGGLSGIGG 141

Query: 59  -----SVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDL 113
                 VHRLD  TSG++V A    A   L RQF +R   ++Y+A   G P PA+G ++ 
Sbjct: 142 VIRPGIVHRLDKETSGIMVAAKQDHAHIHLSRQFEQRTIGRRYLALTRGIPQPAQGRIEG 201

Query: 114 PLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGH 173
            +     +R K  V  + G+ A T Y+V+E      A +  +  +GR+HQ+RVHM  +GH
Sbjct: 202 AIGRHPIHRTKMAVVEQGGRAAATRYKVLE-PLGQFALIRCRLESGRTHQIRVHMTHIGH 260

Query: 174 PILGDRFYASPEARAMAP---------------RLLLHAEMLTITHPAYGNSMTFKA--P 216
           P++GD  Y    A+  AP               R  LHA  LT  HP  G  M+FK   P
Sbjct: 261 PLVGDPLYG---AQHKAPSHWPPLHRQRFDQFQRQALHAHTLTFIHPHTGEEMSFKRPPP 317

Query: 217 ADF 219
           ADF
Sbjct: 318 ADF 320


>UniRef50_C8NEP8 Pseudouridine synthase n=1 Tax=Granulicatella adiacens ATCC 49175
           RepID=C8NEP8_9LACT
          Length = 308

 Score =  119 bits (297), Expect = 9e-26,   Method: Compositional matrix adjust.
 Identities = 75/223 (33%), Positives = 117/223 (52%), Gaps = 14/223 (6%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGR----------LEEHKDSVMTRIQRDYPQAE 58
           P+   L I+++DD ++VVNKPSG++  P +          L  H +S+      +  +  
Sbjct: 75  PENIPLDIVFEDDSLIVVNKPSGMVVHPSKGHYSGTLVNALLYHSNSLSDSTSEEIYRPG 134

Query: 59  SVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICD 118
            VHR+D  TSG++V+A      ++L  Q  E +  ++Y+A V GH +   G+VD PL   
Sbjct: 135 LVHRIDKDTSGLLVIAKNNDVHQKLAEQIAENKMNREYIAIVDGHFAHETGVVDAPLSRH 194

Query: 119 WPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGD 178
             NR K +V  + GK A T +EV++  +D  + V  +  TGR+HQ+R HM  + HPI+ D
Sbjct: 195 QTNRLK-RVVEKGGKNAITHFEVLDSFSD-YSLVSCRLETGRTHQIRAHMEFIKHPIVND 252

Query: 179 RFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
             Y      A      LHA  L+ THP  G ++ F+   P +F
Sbjct: 253 PLYHPKGKNATEFGQFLHARTLSFTHPLTGETLNFQVEPPKEF 295


>UniRef50_B9Y836 Pseudouridine synthase n=3 Tax=Firmicutes RepID=B9Y836_9FIRM
          Length = 307

 Score =  119 bits (297), Expect = 1e-25,   Method: Compositional matrix adjust.
 Identities = 81/222 (36%), Positives = 114/222 (51%), Gaps = 22/222 (9%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPG------------RLEEHKDSVMTRIQRDYPQ 56
           PQE  L ++Y+D  ++V+NKP GL+  PG                H  S +  + R    
Sbjct: 75  PQEMALNVVYEDHDVIVINKPKGLVVHPGPGNPDHTLVNGLLWHCHDLSGINGVLR---- 130

Query: 57  AESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLI 116
              VHR+D  TSG+IV      A + L +Q  E+   +QY A V G  +   G +D P+ 
Sbjct: 131 PGIVHRIDKDTSGLIVACKNDNAHQSLAKQLAEKTAGRQYYALVHGVINHEYGTIDAPIG 190

Query: 117 CDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPIL 176
            D  +R K  V  +  +PA T ++VVE   DN   V  +  TGR+HQ+RVHM  +G PI+
Sbjct: 191 RDEKDRQKMAVTEKNSRPAITHFKVVE-RFDNYTLVSCRLETGRTHQIRVHMQYIGFPIV 249

Query: 177 GDRFYASPEARAMAPR--LLLHAEMLTITHPAYGNSMTFKAP 216
           GD  Y+    R   P    +LHA  L+ THP+ G  MTF+AP
Sbjct: 250 GDPKYS---LRKTLPTQGQMLHAYQLSFTHPSTGERMTFEAP 288


>UniRef50_Q2W2D5 Pseudouridine synthase n=39 Tax=Bacteria RepID=Q2W2D5_MAGSA
          Length = 505

 Score =  119 bits (297), Expect = 1e-25,   Method: Compositional matrix adjust.
 Identities = 78/231 (33%), Positives = 119/231 (51%), Gaps = 25/231 (10%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLL--SVPGRLEE--------HKDSVMTRIQRDYPQAE 58
           PQ+  L ++Y+D+ ++V++KP+G++    PG  +E        H    +  I     +  
Sbjct: 260 PQDIALTVVYEDEDLIVIDKPAGMVVHPAPGNPDETLVNALLAHCGESLAGIG-GVKRPG 318

Query: 59  SVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICD 118
            VHR+D  TSG++V A T AA R L  QF     ++ Y A VWG PSP +G ++  +  +
Sbjct: 319 IVHRIDKDTSGLLVAAKTDAAHRGLATQFAAHTLERAYWALVWGTPSPRQGEIEGNIGRN 378

Query: 119 WPNRPKQKVCYETGKPAQTEYEVVE-YAADNTARVVLKPITGRSHQLRVHMLALGHPILG 177
             +R K  V    GKPA T Y V++ +A    + V  +  TGR+HQ+RVHM   GHP++G
Sbjct: 379 PNDRKKMAVVKSGGKPALTRYRVLKSFAGGAVSLVECRLATGRTHQIRVHMTTQGHPLVG 438

Query: 178 DRFYAS----------PEARAMA---PRLLLHAEMLTITHPAYGNSMTFKA 215
           D  Y            PE +      PR  LHA +L  +HP  G  + F++
Sbjct: 439 DPVYGRIRGHKGVVLPPEVKTALIQFPRQALHAYLLGFSHPTKGYDVRFES 489


>UniRef50_A7HM17 Pseudouridine synthase n=2 Tax=Thermotogaceae RepID=A7HM17_FERNB
          Length = 314

 Score =  118 bits (296), Expect = 1e-25,   Method: Compositional matrix adjust.
 Identities = 83/228 (36%), Positives = 118/228 (51%), Gaps = 21/228 (9%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVP-----------GRLEEHKD-SVMTRIQRDYPQ 56
           P++  L I+Y+D  I+V+NK  G+++ P           G L   KD   +  + R    
Sbjct: 74  PEDIPLDIIYEDRDILVINKQPGIITHPIPSHTSGTIVNGVLYHCKDLQGIGGVLR---- 129

Query: 57  AESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLI 116
              VHRLD  TSGV+V+A    A + L +QF++R  +K Y+  V G P   EG +++ + 
Sbjct: 130 PGIVHRLDKDTSGVMVIAKNDLAHQSLTKQFKDRLTEKLYICLVKGVPKRKEGDIEINIA 189

Query: 117 CDWPNRPKQKVC-YETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPI 175
            +   R K  V   E GKPA T Y+VV    D  A V   P TGR+HQ+RVHM  +GHP+
Sbjct: 190 RNPVLRVKMTVTNSEYGKPALTHYKVVREFGDIAALVFAYPKTGRTHQIRVHMKYIGHPL 249

Query: 176 LGDRFYASPEARAM--APRLLLHAEMLTITHPAYGNSMTF--KAPADF 219
           +GD  Y   +   +    R +LHA  L+  HP  G  + F  K P DF
Sbjct: 250 MGDEVYGRAKEDEIFGIKRQMLHALSLSFYHPRTGEKVKFIAKIPQDF 297


>UniRef50_A3ZV48 Pseudouridine synthase n=1 Tax=Blastopirellula marina DSM 3645
           RepID=A3ZV48_9PLAN
          Length = 281

 Score =  118 bits (295), Expect = 1e-25,   Method: Compositional matrix adjust.
 Identities = 82/226 (36%), Positives = 115/226 (50%), Gaps = 25/226 (11%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES---------VHRLD 64
           L I+YQDD I V+NKP+G+++ P +    K ++   ++  +PQ  +         VHRLD
Sbjct: 39  LDIIYQDDRIAVINKPAGMITHPAK-GHWKGTLTEGLKGQFPQLSTIGGPTRPGIVHRLD 97

Query: 65  MATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPK 124
             TSGVIV+A   AA   LK QF++R  +K+Y A V G P     L++ P+      R +
Sbjct: 98  RDTSGVIVIAKDDAAHEFLKTQFQDRLTEKEYFAMVIGAPDRDRDLINEPVGPHPKIRER 157

Query: 125 QKV--CYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYA 182
             +    + GK AQT YEV+E      A   L P TGR+HQ+RVH++  GHP+L D  Y 
Sbjct: 158 MAIRRGDDEGKDAQTFYEVLERYQGFAAIKAL-PKTGRTHQIRVHLMHAGHPVLCDPLYG 216

Query: 183 S------------PEARAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
           S             +   +  R  LHA  + I HP  G    F AP
Sbjct: 217 SRRFLSLGELQHDDDRTVLLNRTALHAHRIAIAHPDDGEIREFIAP 262


>UniRef50_Q057L6 Pseudouridine synthase n=1 Tax=Buchnera aphidicola str. Cc (Cinara
           cedri) RepID=Q057L6_BUCCC
          Length = 317

 Score =  118 bits (295), Expect = 2e-25,   Method: Compositional matrix adjust.
 Identities = 70/210 (33%), Positives = 116/210 (55%), Gaps = 8/210 (3%)

Query: 16  ILYQDDHIMVVNKPSGLLSVPGR-LEEHKDSVMTRIQRDYPQAESVHRLDMATSGVIVVA 74
           IL++D+ +++ NKP G     G  +      +  +I+ D    E VHR+D  TSG+++++
Sbjct: 94  ILFEDNDLIIFNKPYGFAVHGGSGISYGVIEIFRKIRSDLKFLELVHRIDKETSGILILS 153

Query: 75  LTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVC-YETGK 133
             ++  +++    RE++  K+Y+A + G+ S    +V LPL+     + K+KVC ++ GK
Sbjct: 154 KKRSILKKMHINLREKKIYKEYLAILHGYWSKKNKIVKLPLLKKKNIKQKKKVCVHKEGK 213

Query: 134 PAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARAMA--- 190
            AQT +E+ +Y  +N   V + PITGR+HQ+RVH    GHPI+ D  Y   E +      
Sbjct: 214 LAQTNFEIKKY-LNNKTLVKIIPITGRTHQIRVHTAQFGHPIVFDNRYGKIEKKKKKIIK 272

Query: 191 --PRLLLHAEMLTITHPAYGNSMTFKAPAD 218
              RLLLHA  ++  HP    + +  AP D
Sbjct: 273 KNSRLLLHAFKVSFLHPRNNENFSITAPLD 302


>UniRef50_A9NGF1 Pseudouridine synthase n=1 Tax=Acholeplasma laidlawii PG-8A
           RepID=A9NGF1_ACHLI
          Length = 297

 Score =  118 bits (295), Expect = 2e-25,   Method: Compositional matrix adjust.
 Identities = 81/226 (35%), Positives = 117/226 (51%), Gaps = 18/226 (7%)

Query: 4   ENYNP--PQEPWLVILYQDDHIMVVNKPSGLLSVPGR----------LEEHKDSVMTRIQ 51
           E  NP  P+   L I+Y+DD IMV+NKP GL+  P            L  H D++ T   
Sbjct: 64  EETNPLKPKNIDLNIVYEDDDIMVINKPKGLVVHPSETFSETTLVSGLLHHTDTLST--H 121

Query: 52  RDYPQAESV-HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGL 110
            D P    + HR+D  TSG+I+VA T  A + L +  +  + K++Y+A V G     +G+
Sbjct: 122 NDDPLRPGILHRIDKDTSGLILVAKTNEAHKILAQDLKSHDIKREYIALVEGVLDHNKGV 181

Query: 111 VDLPLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLA 170
           +D P I   P    +     TGKPA T +EV+    D+T  +  K  TGR+HQ+RVH+  
Sbjct: 182 IDAP-IARHPKIRTKMAVVATGKPAITHFEVMRTFRDHTL-LHCKLETGRTHQIRVHLAY 239

Query: 171 LGHPILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
           + HP+ GD  Y + +A+ +    LLHA  L   HP     M  +AP
Sbjct: 240 IKHPVTGDPLYGT-KAKILKDGQLLHAFRLEFVHPITKKVMMLEAP 284


>UniRef50_A6NQQ9 Pseudouridine synthase n=1 Tax=Bacteroides capillosus ATCC 29799
           RepID=A6NQQ9_9BACE
          Length = 300

 Score =  117 bits (294), Expect = 2e-25,   Method: Compositional matrix adjust.
 Identities = 79/214 (36%), Positives = 111/214 (51%), Gaps = 20/214 (9%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES-------VHRLDMA 66
           L I+YQD  ++V+NK  G+   PG    H    +     DY + +        VHRLD  
Sbjct: 84  LDIVYQDQDVLVLNKAPGVAVHPG--PGHYSDTIGNFLMDYYRKQGILADFHPVHRLDRG 141

Query: 67  TSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQK 126
           TSG+++VAL   A+  LK Q      ++ Y+A   G P+P  G++D P+      R +  
Sbjct: 142 TSGLLLVALHGHAQEVLKEQLHSPSFRRVYLAVCEGAPNPPSGVIDAPI-----GRLEGS 196

Query: 127 VCYETGKP----AQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYA 182
           V   T +P    A T Y  +    D  A V L+  TGR+HQ+RVHM  LGHP+ GD  Y 
Sbjct: 197 VLARTVRPDGQRAVTHYRTLRTVNDR-ALVRLELETGRTHQIRVHMAHLGHPLTGDFLYG 255

Query: 183 SPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
           + E +++ PR  LHA  L+ THP  G +M F AP
Sbjct: 256 T-EDQSLIPRPALHAAELSFTHPITGKTMAFTAP 288


>UniRef50_B7G8W7 Predicted protein (Fragment) n=1 Tax=Phaeodactylum tricornutum CCAP
           1055/1 RepID=B7G8W7_PHATR
          Length = 235

 Score =  117 bits (294), Expect = 2e-25,   Method: Compositional matrix adjust.
 Identities = 83/241 (34%), Positives = 117/241 (48%), Gaps = 41/241 (17%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES------VHRLDMAT 67
           L I+Y D  I+VVNKP  +L+VPG     +  V+  +   + +A        VHRLDMAT
Sbjct: 1   LQIVYHDSDIVVVNKPPDVLTVPG--IHSRSCVLDLVHDRFGEAVQDKAHMIVHRLDMAT 58

Query: 68  SGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKV 127
           SG+++   T    + ++  FR+R   K Y A + GH    +G +DLPL  D    P  ++
Sbjct: 59  SGIVLFGRTLNITKRMQAIFRDRLVLKTYQALLMGHFPIDKGTIDLPLQRDHEYPPFMRI 118

Query: 128 CYETG------------------------KPAQTEYEVVEYAADNT---ARVVLKPITGR 160
              T                         KP+QT + V+  +  N     R+ L P+TGR
Sbjct: 119 STPTSEADAVQAVKDLQQHGWKKLIRKKPKPSQTSFRVLARSFRNGLPFTRMELVPVTGR 178

Query: 161 SHQLRVHMLALGHPILGDRFYAS--PEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           +HQLRVH  ALG+PI+GD  Y    P  +AM     LHA +L   HP  G  + F+A  D
Sbjct: 179 THQLRVHCAALGYPIVGDPTYDEYVPNEKAMC----LHAALLQCEHPTTGMPIVFEASPD 234

Query: 219 F 219
           F
Sbjct: 235 F 235


>UniRef50_C6BSG2 Pseudouridine synthase, RluA family n=1 Tax=Desulfovibrio
           salexigens DSM 2638 RepID=C6BSG2_DESAD
          Length = 549

 Score =  117 bits (293), Expect = 2e-25,   Method: Compositional matrix adjust.
 Identities = 81/232 (34%), Positives = 120/232 (51%), Gaps = 22/232 (9%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES--------V 60
           P+E  L I+Y D  I V+NKP+GL + P        +++ R+   +P+           V
Sbjct: 89  PEELPLEIIYNDGKIAVINKPAGLTTHPAP-SCPTGTLVHRMIHHFPEIRDMDEWRPGIV 147

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLD  TSG+I VAL +     +   F +RE  K Y+A V G P    G +D P+     
Sbjct: 148 HRLDKFTSGLITVALNEHDRLAMSTAFADREVNKAYLAIVHGVPKREFGEIDQPMGRHPV 207

Query: 121 NRPKQKVCYETGKPAQTEYEVV-EYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDR 179
           ++ K  V  + G+ A++EYEV+    A   + V +K  TGR+HQ+RVHM  +GHP++GD+
Sbjct: 208 HKTKMAVVLKGGRDARSEYEVLWSDPAGRASLVKVKIYTGRTHQIRVHMAHIGHPLVGDQ 267

Query: 180 FYAS----------PEARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
            Y S          P+   +A R +LHA  L+ THP     ++F    P DF
Sbjct: 268 VYGSMPHAIWEQDQPQLAKLAERQMLHAYSLSFTHPDSEEELSFTQAPPEDF 319


>UniRef50_Q2G4F0 Pseudouridine synthase n=12 Tax=Alphaproteobacteria
           RepID=Q2G4F0_NOVAD
          Length = 436

 Score =  117 bits (293), Expect = 3e-25,   Method: Compositional matrix adjust.
 Identities = 76/210 (36%), Positives = 116/210 (55%), Gaps = 10/210 (4%)

Query: 15  VILYQDDHIMVVNKPSGLLSVPGR-LEEHKDSVMTR-IQRDYPQAESVHRLDMATSGVIV 72
           ++L +D   +V+NKP GL +  G    EH D ++   +     +   VHRLD  TSGV++
Sbjct: 103 MVLEKDRAAIVLNKPPGLATQGGSGTHEHVDGLLDAYVNEGEARPRLVHRLDKDTSGVLL 162

Query: 73  VALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYE-- 130
           +A T  +     ++F  R  +K Y A V G P   +GL++LPL    P    +K+  +  
Sbjct: 163 IARTPGSAAFFSKRFSCRSARKIYWALVVGVPDVKDGLIELPL-AKQPGTGGEKMMVDES 221

Query: 131 -TGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEA--- 186
             G+ A++ Y V+  A +  A V L+P+TGR+HQLRVHM A+GHPI+GD  Y    A   
Sbjct: 222 GQGQSARSRYRVISRAGNAAAWVELQPLTGRTHQLRVHMAAIGHPIVGDGKYGGQAAFLT 281

Query: 187 RAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
            +++ ++ LHA  L I HP  G+ +   AP
Sbjct: 282 GSISRKMHLHARRLRIEHP-EGDMIDVTAP 310


>UniRef50_B5Y592 Predicted protein (Fragment) n=1 Tax=Phaeodactylum tricornutum CCAP
           1055/1 RepID=B5Y592_PHATR
          Length = 175

 Score =  117 bits (293), Expect = 3e-25,   Method: Compositional matrix adjust.
 Identities = 73/175 (41%), Positives = 102/175 (58%), Gaps = 7/175 (4%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPG--RLEEHKDSVMTRIQRDYPQAES--VHRLDMATSG 69
           L I+++D+HI+VV+KPSG+L+VP    +     +V    Q      +   VHRL M TSG
Sbjct: 1   LKIVHEDEHIIVVDKPSGVLTVPSDKNVPSLAQAVFDHCQPTEVTLDQMVVHRLGMDTSG 60

Query: 70  VIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCY 129
           +IV+A T    R++   FR R+  +QY A V GH     GL+ LPL+ D+ + P  +   
Sbjct: 61  LIVLAKTMDTVRQMNALFRTRKITRQYEALVVGHLPQHGGLISLPLMRDYEHPPYMRKLL 120

Query: 130 ETGKPAQTEYEVVEYA-ADNT--ARVVLKPITGRSHQLRVHMLALGHPILGDRFY 181
           E  K + T+YEVV     D T  +RV L  I+GR+HQL VH+ A GHPI+GD  Y
Sbjct: 121 EMPKESLTKYEVVNREDMDGTPVSRVALTSISGRTHQLNVHLAAFGHPIVGDSVY 175


>UniRef50_B8GX34 Pseudouridine synthase n=7 Tax=Caulobacteraceae RepID=B8GX34_CAUCN
          Length = 331

 Score =  117 bits (293), Expect = 3e-25,   Method: Compositional matrix adjust.
 Identities = 72/205 (35%), Positives = 115/205 (56%), Gaps = 15/205 (7%)

Query: 15  VILYQDDHIMVVNKPSGLLSVPG-RLEEHKDSVMTRIQRDYPQAESVHRLDMATSGVIVV 73
           ++LY+D+ ++ +NKP+GL    G +  +H D +++       +   VHRLD  TSGV+++
Sbjct: 92  LVLYEDEEVLALNKPAGLAVQGGTKTTKHIDKLLSAWGEGVDRPRLVHRLDRDTSGVLLL 151

Query: 74  ALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPL----ICDW----PNRPKQ 125
             T +A   L   F +R+ +K Y A V G+P P EG+++L L    + D     P +PK 
Sbjct: 152 GKTPSAAARLSGAFAKRKAQKTYWAIVAGNPHPTEGVMELHLAKRGVGDRELVVPAQPKD 211

Query: 126 KVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPE 185
                  +PA+TE+  +  A      + L+P TGR+HQLR HM A+GHPILGD  Y   +
Sbjct: 212 ----PDAQPAETEFVTISRAGPRVTWMALRPHTGRTHQLRAHMKAMGHPILGDPKYGDEK 267

Query: 186 ARAMAP--RLLLHAEMLTITHPAYG 208
           +  ++   +L LHA  + + HP+ G
Sbjct: 268 SAPLSEGLKLQLHARSILLPHPSAG 292


>UniRef50_A9BMW0 Pseudouridine synthase n=10 Tax=Comamonadaceae RepID=A9BMW0_DELAS
          Length = 356

 Score =  117 bits (292), Expect = 3e-25,   Method: Compositional matrix adjust.
 Identities = 82/220 (37%), Positives = 123/220 (55%), Gaps = 17/220 (7%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLS--VPGRLEEHK-DSVMTR--IQRDYPQAESVHRL 63
           P++  L ++Y+D+H++VVNKP+GL+    PG       + ++ R    R+ P+A  VHRL
Sbjct: 120 PEDMALDVVYEDEHLLVVNKPAGLVVHPAPGNWTGTLLNGLLGRDPKAREVPRAGIVHRL 179

Query: 64  DMATSGVIVVALTKAAERELKRQFREREPKKQYVA---RVWGHPSPAEGLVDLPLICDWP 120
           D  TSG++VVA ++AA   L      R+  +QY+A   + WG     E  VD P+  D  
Sbjct: 180 DKDTSGLMVVARSRAAMDALVAMIAARDVSRQYLALAHKAWGPRKHRE--VDAPIGRDPR 237

Query: 121 NRPKQKV---CYETGKPAQTEYEVVEYAADNTARVVLKPI-TGRSHQLRVHMLALGHPIL 176
           NR +  V       GK A+T+ +++  A +    +V   + TGR+HQ+RVHM +LGHP++
Sbjct: 238 NRLRMAVVDLAQHAGKTARTDIDLL--AGNEEVSLVRCTLHTGRTHQIRVHMASLGHPLV 295

Query: 177 GDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
            D  Y   EA  MA R  LHA  L  THP  G ++  +AP
Sbjct: 296 ADAVYGGKEAGGMA-RQALHAFRLAFTHPMTGQALVLRAP 334


>UniRef50_C7RM94 Pseudouridine synthase n=11 Tax=Proteobacteria RepID=C7RM94_9PROT
          Length = 375

 Score =  117 bits (292), Expect = 3e-25,   Method: Compositional matrix adjust.
 Identities = 82/226 (36%), Positives = 125/226 (55%), Gaps = 18/226 (7%)

Query: 7   NPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ------AESV 60
           + P+E  L I+++DD ++V++K +GL+  PG     + +++  +    PQ      A  V
Sbjct: 100 SAPEEIPLRIVFEDDTLIVLDKQAGLVVHPGS-GNWRGTLLNGLLHHAPQLARVPRAGIV 158

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLD  T+G++VVA T  A+ +L RQ + R  K+ Y A V G    A G+VD P I   P
Sbjct: 159 HRLDKDTTGLMVVAKTLEAQTDLVRQLQARSVKRCYQALVRGIVEGA-GIVDAP-IGRHP 216

Query: 121 NRPKQKVCYETGKPAQTEYEVVE-YAADNTARVVLKPITGRSHQLRVHMLALGHPILGDR 179
               +      G+PA+T Y V+E + A       L+  TGR+HQ+RVHM ++ HP++GD 
Sbjct: 217 TVRTRMAVVSGGRPARTHYRVLERFVACTLIECALE--TGRTHQIRVHMTSIAHPLVGDP 274

Query: 180 FYASPEAR----AMAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
            Y    +R    A+ PR  LHA  L + HPA G +M +++  PAD 
Sbjct: 275 IYGGGASRVPQGAVFPRQALHACRLALVHPASGKAMLWRSGVPADM 320


>UniRef50_D2BIX0 Pseudouridine synthase n=5 Tax=Dehalococcoides RepID=D2BIX0_DEHSV
          Length = 302

 Score =  116 bits (291), Expect = 5e-25,   Method: Compositional matrix adjust.
 Identities = 77/213 (36%), Positives = 113/213 (53%), Gaps = 16/213 (7%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKD-SVMTRIQRDYPQAES---------VHRL 63
           L I++QD  ++++NKP GL   P     H D +++  +    P+ E          VHRL
Sbjct: 80  LEIIFQDKDLLLINKPPGLTVHPA--PGHPDHTLINGVLALEPKMEDFDDPLRPGIVHRL 137

Query: 64  DMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRP 123
           D  TSG+++VA  +     L  QF+ER  +K Y+  V G   PAEG ++ PL  D  NR 
Sbjct: 138 DKDTSGLLLVAKNRETLANLSAQFKERTVRKYYLTLVKGELHPAEGFIEAPLGRDPQNRQ 197

Query: 124 KQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYAS 183
           K  V    G+ A+T Y+V+ Y     + + +K  TGR+HQ+RVH  A+GHP+ GD  Y  
Sbjct: 198 KIAVV-SNGRHARTGYKVLRY-IQGYSLLEVKLETGRTHQIRVHFAAIGHPVAGDAIYGQ 255

Query: 184 PEARAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
            E      R  LHA  L+ T P+ G ++ F +P
Sbjct: 256 KE--TWLKRQFLHAHRLSFTLPSNGQTVEFTSP 286


>UniRef50_A9BFW4 Pseudouridine synthase n=8 Tax=Thermotogaceae RepID=A9BFW4_PETMO
          Length = 319

 Score =  116 bits (291), Expect = 5e-25,   Method: Compositional matrix adjust.
 Identities = 86/231 (37%), Positives = 119/231 (51%), Gaps = 17/231 (7%)

Query: 4   ENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVP------GRLEE---HKDSVMTRIQRDY 54
           EN  P   P L ILY+D+ ++V+NKP+GL+  P      G L     H    + +  +D 
Sbjct: 76  ENILPENIP-LNILYEDEELIVINKPAGLIVHPTPSIKTGTLVNALMHHVKDLDKTMQDP 134

Query: 55  PQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLP 114
            +   VHRLD  TSGV+VVA    +   L ++F+ER+  K Y+A V G     EG ++LP
Sbjct: 135 NRLGIVHRLDKETSGVLVVAKNAFSHHLLSKEFKERKTMKYYLAIVEGTLKEKEGEINLP 194

Query: 115 LICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHP 174
           L      R K+ V Y  GK A TEY+ ++   D    V ++  TGR+HQ+RVH   +G+P
Sbjct: 195 LGRHPILRHKRAVVY-NGKEAITEYKTLKEFGDLATLVWIRLRTGRTHQIRVHFKYIGNP 253

Query: 175 ILGDRFYASP--EARAMAP--RLLLHAEMLTITHPAYGNSMTFKAPA--DF 219
           ++GD  Y     E     P  R +LHA  L   HP     M F AP   DF
Sbjct: 254 LIGDSLYGKNKIEKNLQIPVGRQMLHALKLGFYHPKTKEWMEFLAPLPDDF 304


>UniRef50_P70870 Ribosomal large subunit pseudouridine synthase D n=23 Tax=Borrelia
           RepID=RLUD_BORBU
          Length = 326

 Score =  116 bits (291), Expect = 5e-25,   Method: Compositional matrix adjust.
 Identities = 74/208 (35%), Positives = 107/208 (51%), Gaps = 19/208 (9%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPG----------RLEEHKDSVMTRIQRDYPQAE 58
           P    + I+Y+D +++V+NKP G+LS PG           L  H  S+      +  +  
Sbjct: 79  PSNIPIAIIYEDSNVIVLNKPQGILSHPGISHWDDTVVNFLLYHIKSLKINFNEEKIRPG 138

Query: 59  SVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICD 118
            VHRLD  TSGV++ A   +  R L +QF+++   K Y+A V G+ +   G ++  +  D
Sbjct: 139 IVHRLDKDTSGVLICAKNISTLRFLAQQFKDKRTNKVYIAIVKGNFNSFFGSIESFIDRD 198

Query: 119 WPNRPKQKVCYETGKPAQTEYEVV----EYAADNTARVVLKPITGRSHQLRVHMLALGHP 174
             NR K  V  + GK A TEY ++    EY+      + LKP TGR+HQLRVHM  L  P
Sbjct: 199 KHNRKKFSVSKDRGKKALTEYRLLLNFGEYSL-----LALKPKTGRTHQLRVHMKYLNFP 253

Query: 175 ILGDRFYASPEARAMAPRLLLHAEMLTI 202
           ILGD  Y   +       L+LH+  L I
Sbjct: 254 ILGDEVYGRVDGSLKKITLMLHSYKLEI 281


>UniRef50_D1PCC3 Pseudouridine synthase n=1 Tax=Prevotella copri DSM 18205
           RepID=D1PCC3_9BACT
          Length = 387

 Score =  116 bits (290), Expect = 6e-25,   Method: Compositional matrix adjust.
 Identities = 79/242 (32%), Positives = 115/242 (47%), Gaps = 33/242 (13%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSV---------MTRIQRDYPQAES 59
           P+E  + ++Y+DD +MVVNK +G++  PG    H   +         M     + P+   
Sbjct: 126 PEEIAINVVYEDDQLMVVNKEAGMVVHPGAGNFHGTLIQAVAWHLRDMPEFDANDPEVGL 185

Query: 60  VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDW 119
           VHR+D  TSG++VVA T  A+  L +QF  +   + Y A VWG+    EG ++  +  D 
Sbjct: 186 VHRIDKDTSGLLVVAKTPTAKNALGKQFFNKTTHRSYNALVWGNIVEDEGRIEGNIGRDP 245

Query: 120 PNRPKQKVC---YETGKPAQTEYEVVE-YAADNTARVVLKPITGRSHQLRVHMLALGHPI 175
            NR + KV       GK A T Y+V+E +      + VL+  TGR+HQ+R HM  +GHP+
Sbjct: 246 KNRLRMKVFDPDSGIGKTAVTHYKVLERFGYTTLVQCVLE--TGRTHQIRAHMKHIGHPL 303

Query: 176 LGDRFYASPE----------------ARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PA 217
             D  Y   E                   + PR  LHA+ L   HP     M F +  P 
Sbjct: 304 FMDETYGGTEILRGQRSSSYKAFIQNCFKLCPRQALHAKTLGFVHPTTKQQMDFDSEWPN 363

Query: 218 DF 219
           DF
Sbjct: 364 DF 365


>UniRef50_A1URK8 Pseudouridine synthase n=2 Tax=Bartonella RepID=A1URK8_BARBK
          Length = 336

 Score =  115 bits (289), Expect = 7e-25,   Method: Compositional matrix adjust.
 Identities = 85/241 (35%), Positives = 114/241 (47%), Gaps = 41/241 (17%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES------------VH 61
           L IL++DDHI+VVNKP+GL+  PG        V   I   Y   +S            VH
Sbjct: 80  LHILFEDDHIIVVNKPAGLVVHPGHGNWTGTLVNALI---YHCGDSLSGIGGVRRPGIVH 136

Query: 62  RLDMATSGVIVVALTKAAERELKRQF----REREPKKQYVARVWGHPSPAEGLVDLPLIC 117
           RLD  TSGVIVVA    A + L  QF    R     ++Y A +WG P+   G++   L  
Sbjct: 137 RLDKNTSGVIVVAKNDLAHKGLSAQFSDHGRTGVLDRRYHALIWGSPNRNIGVITASLGR 196

Query: 118 DWPNRPKQKVCYE---TGKPAQTEYEVVEYAADNTARVVLKPI------TGRSHQLRVHM 168
              +R KQ V +      + A T + V+E       ++    +      TGR+HQ+RVHM
Sbjct: 197 ARYDRTKQAVIHSHNIYARHAVTHFSVIEKYQTCADKIPFASLLECRLETGRTHQIRVHM 256

Query: 169 LALGHPILGDRFYASP-------------EARAMAPRLLLHAEMLTITHPAYGNSMTFKA 215
             +GHP++GD  Y +              EA  +  R  LHA  LT  HPA GN M+F A
Sbjct: 257 AHIGHPLVGDTVYGNAFKTKSNRFDSTIKEAIDLFNRQALHAASLTFEHPAKGNIMSFSA 316

Query: 216 P 216
           P
Sbjct: 317 P 317


>UniRef50_C4FYR8 Pseudouridine synthase n=1 Tax=Abiotrophia defectiva ATCC 49176
           RepID=C4FYR8_ABIDE
          Length = 326

 Score =  115 bits (289), Expect = 8e-25,   Method: Compositional matrix adjust.
 Identities = 75/222 (33%), Positives = 114/222 (51%), Gaps = 16/222 (7%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGR----------LEEHKDSVMTRIQRDYPQAE 58
           P+   L ILY+D+ ++++NKP G++  P            L  H    ++ I  +  +  
Sbjct: 94  PENIPLDILYEDEDVILINKPKGMVVHPAAGHYTGTLVNALMYHCRDNLSGINGEL-RPG 152

Query: 59  SVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICD 118
            VHR+DM T+GVI+      + R +  Q +E   K++Y A V+G     EG ++  +   
Sbjct: 153 IVHRIDMDTTGVIIACKNDVSHRIIAEQLKEHSIKRKYQAIVYGVFKDEEGRIEGSIGRS 212

Query: 119 WPNRPKQKVCYETGKPAQTEYEVV-EYAA---DNTARVVLKPITGRSHQLRVHMLALGHP 174
             +R K  V  + GKPA T Y V+  Y +   +N A +  +  TGR+HQ+RVHM ++GHP
Sbjct: 213 KTDRKKMAVIPD-GKPAVTHYRVIRNYTSPNGNNFAHIECELETGRTHQIRVHMTSIGHP 271

Query: 175 ILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
           +LGD  Y + +         LHAEML   HP  G  M F AP
Sbjct: 272 LLGDEIYGAAKNPFKLDGQALHAEMLGFVHPRTGEYMEFHAP 313


>UniRef50_D1Y3Y9 Pseudouridine synthase n=1 Tax=Pyramidobacter piscolens W5455
           RepID=D1Y3Y9_9BACT
          Length = 345

 Score =  115 bits (289), Expect = 8e-25,   Method: Compositional matrix adjust.
 Identities = 79/213 (37%), Positives = 114/213 (53%), Gaps = 16/213 (7%)

Query: 16  ILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES---------VHRLDMA 66
           ++Y+DD ++VVNKP+G++  PG       +++  +   YP+            VHRLD+ 
Sbjct: 118 VVYEDDDVIVVNKPAGVVVHPG-AGRPDGTLVNGLMFRYPEIGRIGDSVRPGIVHRLDVG 176

Query: 67  TSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQK 126
           TSG++VVA + AA R L   F+  E  K+Y+    G     EG VD P+  D  NR K  
Sbjct: 177 TSGLMVVARSDAAFRGLTEAFQAHEVLKEYLGLGVGALKAPEGTVDAPIGRDPRNRLKMC 236

Query: 127 VCYETGKPAQTEYEVV-EYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYA--S 183
           V ++ G+ A T+Y+V+   A  N  RV L   TGR+HQ+RVHM ALG  + GD  Y    
Sbjct: 237 VSWD-GRDAVTDYKVLWTRARCNLIRVRLH--TGRTHQIRVHMRALGCSLDGDTLYGPKD 293

Query: 184 PEARAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
           P    +  R+ LH+  L   HP  G  + F+AP
Sbjct: 294 PAQHILKDRVFLHSWRLGFRHPVSGERLEFRAP 326


>UniRef50_A1AW00 Pseudouridine synthase n=2 Tax=sulfur-oxidizing symbionts
           RepID=A1AW00_RUTMC
          Length = 314

 Score =  115 bits (289), Expect = 8e-25,   Method: Compositional matrix adjust.
 Identities = 80/229 (34%), Positives = 122/229 (53%), Gaps = 30/229 (13%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPG---------RLEEHKDSVMTRIQRDYPQAESV 60
           Q+  + ++Y+D+ I++VNKP  L++ PG             H DS +  + R    A  V
Sbjct: 76  QDIVIDVVYEDEAIIIVNKPVNLVTHPGVSNWTGTLANALLHYDSSLANLDR----AGIV 131

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLD  TSG++VVA ++ A++ L RQ +     ++Y A V+GH     G VD P+  D  
Sbjct: 132 HRLDKNTSGLMVVARSEYAQKYLTRQLQTHSISREYSAIVYGHMISG-GTVDKPIGRDPK 190

Query: 121 NRPKQKVCYETGKPAQTEYEVVEYAADNT-ARVVLKPITGRSHQLRVHMLALGHPILGDR 179
           +R +Q V  E+GK A T Y V+E  A +T  +V+L+  TGR+HQ+RVH+  +GHP++ D 
Sbjct: 191 DRIRQTVT-ESGKDALTHYRVIERFAHHTHVKVMLE--TGRTHQIRVHLSFIGHPLIADP 247

Query: 180 FYAS------------PEARAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
            Y                +     R  LHA+ LT+ HP     M++K P
Sbjct: 248 MYGGKIRFPKKADKQLKNSLKNFNRQTLHAKKLTLIHPTSTELMSWKVP 296


>UniRef50_Q492Q1 Pseudouridine synthase n=2 Tax=Candidatus Blochmannia
           RepID=Q492Q1_BLOPB
          Length = 338

 Score =  115 bits (289), Expect = 9e-25,   Method: Compositional matrix adjust.
 Identities = 74/213 (34%), Positives = 111/213 (52%), Gaps = 13/213 (6%)

Query: 15  VILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQA---ESVHRLDMATSGVI 71
           +I+Y+DD+++ +NKP+G+ +  G     K  V+  ++   P+A   E VHRLD  TSGV+
Sbjct: 93  IIIYEDDYLLALNKPTGVAAHGG--SGLKFGVIEGLRALRPKAQFLELVHRLDRETSGVL 150

Query: 72  VVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCY-- 129
           +VA  + A   L  Q R +  KK+Y+A V G  +    +V +PL          +V Y  
Sbjct: 151 LVAKRRTALVYLHEQLRLQNMKKEYLALVHGRWNVNLQIVSVPLFKKNTLLNSSRVVYID 210

Query: 130 -ETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEA-- 186
            E GK + T +++ EY  +    + +KPITGR+HQ+RVH     HPI+GD  Y   ++  
Sbjct: 211 SENGKFSTTHFQIKEYFDNVATFLAIKPITGRTHQIRVHTQYASHPIVGDNRYGDYQSNT 270

Query: 187 ---RAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
              R    RL LHA +L   HP         AP
Sbjct: 271 RFKRFGFNRLFLHASILRFIHPKTKKKFHIHAP 303


>UniRef50_B8BQ07 Predicted protein n=1 Tax=Thalassiosira pseudonana CCMP1335
           RepID=B8BQ07_THAPS
          Length = 246

 Score =  115 bits (288), Expect = 9e-25,   Method: Compositional matrix adjust.
 Identities = 82/233 (35%), Positives = 113/233 (48%), Gaps = 26/233 (11%)

Query: 7   NPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDMA 66
           N P    + +LY DD I+V++KP+ L SVPG      D+      +   Q   VHRLD  
Sbjct: 14  NVPPHLTIRVLYSDDDIVVIDKPANLRSVPGHASNSPDA--DDGSKSKYQLHVVHRLDCQ 71

Query: 67  TSGVIVVALTKAAERELKRQFRERE-PKKQYVARVWGHP-----SPAEGLVDLPLICDWP 120
           TSG++VVA    A  +L   +RER+  +K Y+A     P       +EG +DLPL     
Sbjct: 72  TSGIMVVARNSTAASKLCHAWRERDIVQKTYLAYCQRWPPYHDEQLSEGTIDLPLAASRT 131

Query: 121 NRPKQKV--CYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGD 178
            R K +V    + GKP ++E   VE   DN   + LKPITGR+HQLR+H   +G  I+GD
Sbjct: 132 ERIKWEVRALEDGGKPLKSEL-TVERDNDNGVVLELKPITGRTHQLRIHCATIGSGIVGD 190

Query: 179 RFYASPEARAMAPR---------------LLLHAEMLTITHPAYGNSMTFKAP 216
             Y          +               L LHA  L   HP+ G+ +TF +P
Sbjct: 191 SLYGDSPVEWFGDKPQHGQQTISQSDTQTLRLHAHKLVFPHPSTGSEVTFVSP 243


>UniRef50_D0MK65 Pseudouridine synthase n=1 Tax=Rhodothermus marinus DSM 4252
           RepID=D0MK65_RHOM4
          Length = 235

 Score =  115 bits (288), Expect = 1e-24,   Method: Compositional matrix adjust.
 Identities = 75/208 (36%), Positives = 105/208 (50%), Gaps = 13/208 (6%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES-----VHRLDMATS 68
           L ILY+DD ++ V+KP GL ++P R     D      +R    A       VHRLD   S
Sbjct: 3   LPILYEDDDLLAVHKPEGLAAIPER-----DPSRPSARRLLEAARGERLWVVHRLDKEAS 57

Query: 69  GVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVC 128
           GV++ A    A R +   F +R+ +K Y A V G   P +G +  P+      R    V 
Sbjct: 58  GVLLFARNAEAHRYMNTLFEQRQVRKVYRALVHGRLEPGQGQIRAPIRMYGSGR--MGVD 115

Query: 129 YETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARA 188
            E GKP++T Y V+EY  +  + +   P+TGR HQ+RVH   +GHPI+GD  Y     + 
Sbjct: 116 PERGKPSETRYRVLEYLDEAYSLIEALPLTGRRHQIRVHCYHIGHPIVGDPRYGDRSVQQ 175

Query: 189 MAPRLLLHAEMLTITHPAYGNSMTFKAP 216
             PRL+LHA  +   HP  G  +   AP
Sbjct: 176 RYPRLMLHALSIRFRHPN-GQELEIVAP 202


>UniRef50_A3EQJ0 Pseudouridine synthase n=1 Tax=Leptospirillum rubarum
           RepID=A3EQJ0_9BACT
          Length = 339

 Score =  115 bits (287), Expect = 1e-24,   Method: Compositional matrix adjust.
 Identities = 79/229 (34%), Positives = 120/229 (52%), Gaps = 22/229 (9%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVP------GRL-------------EEHKDSVMTR 49
           P+   L ILY+D+ ++V++KP GL+  P      G L             E+ K      
Sbjct: 90  PENIRLEILYEDEDLIVISKPPGLVVHPAPGHSSGTLVNGLLFHFQSQGDEQKKGEPEEE 149

Query: 50  IQRDYP-QAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAE 108
            + + P +A  VHRLD  TSGV+VV  T++   +L  QF++R   K+Y+A V G      
Sbjct: 150 EEAERPLRAGLVHRLDQDTSGVMVVGKTESVVLDLMNQFKDRSVSKKYLALVKGILPKKR 209

Query: 109 GLVDLPLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHM 168
           G ++ P+     +R K+    + GKP+ T Y V+E   +N + + +  +TGR+HQ+RVH 
Sbjct: 210 GEINAPIGRSTHDR-KKFTVRQDGKPSVTRYRVLETYHENYSLLEVTLLTGRTHQIRVHF 268

Query: 169 LALGHPILGDRFYASPEARAMA-PRLLLHAEMLTITHPAYGNSMTFKAP 216
             LG P+LGD  Y S        PR +LHA  L+  HP+  + M F+AP
Sbjct: 269 RYLGFPLLGDAVYGSKGTENKNFPRQMLHAWKLSFQHPSSNSKMEFEAP 317


>UniRef50_B5YAZ5 Pseudouridine synthase n=2 Tax=Dictyoglomus RepID=B5YAZ5_DICT6
          Length = 226

 Score =  115 bits (287), Expect = 1e-24,   Method: Compositional matrix adjust.
 Identities = 75/217 (34%), Positives = 111/217 (51%), Gaps = 17/217 (7%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES----------VHRL 63
           L ++Y+D+H++VVNKP+G+L V G +   K + +  I + Y + +           VHRL
Sbjct: 7   LEVIYEDNHLLVVNKPAGIL-VQGDIT--KSTTLLEISKAYIKEKYKKPGNVFLAIVHRL 63

Query: 64  DMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRP 123
           D   SGV++ A    +   L   FRER+ +K+Y+A   G     +G +   L+     R 
Sbjct: 64  DKPVSGVVIFARNSKSAGRLSEAFRERKVEKEYIALCKGIFKVKKGTISESLLWVEKERK 123

Query: 124 KQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYAS 183
            +    +  K A T YEV+E    N + V L P TGR HQLR H+  +GHPILGD  Y  
Sbjct: 124 ARVSQDDKSKNAITHYEVLE-EFKNLSLVRLIPETGRKHQLRAHLSYIGHPILGDEKYGG 182

Query: 184 PEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPA-DF 219
              R    R+ LH + + + HP   + M F+A   DF
Sbjct: 183 --GRIFKDRIFLHCKKMAVPHPVRKDIMEFEAKIPDF 217


>UniRef50_Q6AJM1 Pseudouridine synthase n=1 Tax=Desulfotalea psychrophila
           RepID=Q6AJM1_DESPS
          Length = 327

 Score =  115 bits (287), Expect = 1e-24,   Method: Compositional matrix adjust.
 Identities = 77/219 (35%), Positives = 109/219 (49%), Gaps = 11/219 (5%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYPQAESV 60
           PQ+     +Y+DD ++V++KP G++  PG        V   +          D  +   V
Sbjct: 90  PQQVDFESIYEDDSLLVLSKPPGIVVHPGNGNTEGTLVHGLLYHCREIGGVGDAIRPGIV 149

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLD  TSG +VVA  + + R L   F+ER+  K Y A V G P   EG +  P+     
Sbjct: 150 HRLDKDTSGAMVVAKDERSLRTLVDSFKERQVYKVYHALVCGIPKKYEGRIVAPIGRHSV 209

Query: 121 NRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPI---TGRSHQLRVHMLALGHPILG 177
           +R K  +   TGK A T ++VVE          L  +   TGR+HQ+RVHM ++G PI G
Sbjct: 210 HRQKMAISERTGKFAATNWQVVEVFETKDGPYSLLRVHIETGRTHQIRVHMSSIGCPIAG 269

Query: 178 DRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
           D+ Y S        R +LHA  L + HP  G +M+F AP
Sbjct: 270 DQVYGSKRQNPAFARQMLHASRLRLPHPVTGRTMSFTAP 308


>UniRef50_B0T2G2 Pseudouridine synthase n=6 Tax=Caulobacteraceae RepID=B0T2G2_CAUSK
          Length = 286

 Score =  115 bits (287), Expect = 1e-24,   Method: Compositional matrix adjust.
 Identities = 78/203 (38%), Positives = 108/203 (53%), Gaps = 10/203 (4%)

Query: 15  VILYQDDHIMVVNKPSGLLSVPGRLEEH--KDSVMTRIQRDYPQAESVHRLDMATSGVIV 72
           +++++DD + V+NKP+GL S  GR++ H   D +    +RD P+   +HRLD  TSGVI+
Sbjct: 53  LVIHEDDSVFVLNKPAGLSSQGGRIQAHTLDDLLWALARRDRPRPRLIHRLDRDTSGVIL 112

Query: 73  VALTKAAERELKRQFREREPKKQYVARVW-GHPSPAEGLVDLPLICDWPNRPK-QKVC-- 128
            A TK A   L +    +  +K Y A V  G P P  G +D PL  +   R    +VC  
Sbjct: 113 TARTKPAATFLGKALMGKRFRKTYWAIVTPGAPEPRGGQIDSPLRRESIGREAYMRVCEA 172

Query: 129 -YETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASP--E 185
            +   + A++ Y  +  A +  A V L P TGR HQLRVHM ++G PI GD  Y      
Sbjct: 173 DHPDAETARSRYRTLA-ATEGAALVELSPDTGRMHQLRVHMASIGRPIAGDSRYGGALML 231

Query: 186 ARAMAPRLLLHAEMLTITHPAYG 208
             A  PRL+LHA  L   HP  G
Sbjct: 232 GGAPVPRLMLHAANLVFPHPEGG 254


>UniRef50_P59838 Ribosomal large subunit pseudouridine synthase D n=3
           Tax=Gammaproteobacteria RepID=RLUD_BLOFL
          Length = 321

 Score =  114 bits (286), Expect = 2e-24,   Method: Compositional matrix adjust.
 Identities = 80/230 (34%), Positives = 122/230 (53%), Gaps = 26/230 (11%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP-------QAESVH 61
           PQ   L I+Y+D+ I+V+NK S ++  PG +  ++ +V+  +   YP       QA  V 
Sbjct: 81  PQNIPLNIIYEDNDILVINKASNMVVHPG-IGHYQGTVLNALLYRYPSILKISKQAGIVQ 139

Query: 62  RLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPN 121
           RLD  T+G++++A T +A   L R F+ R+  K+Y A V+G  +   G+V+ P+   +  
Sbjct: 140 RLDKDTTGLMIIAKTVSAYDNLLRSFKLRKVVKEYDAIVYGKFTSNAGVVNQPMRRHFAK 199

Query: 122 RPKQKVCYETGKPAQTEYEVV-EYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRF 180
           R    V Y TGK A T Y VV E+ A +  R+ LK  TGR+HQ+RVHM  + HP++GD+ 
Sbjct: 200 RTFMSVHY-TGKSAVTYYSVVEEFKAHSRVRINLK--TGRTHQIRVHMAYINHPLVGDQK 256

Query: 181 YASP----EARAMAPRL----------LLHAEMLTITHPAYGNSMTFKAP 216
           Y       + + M+  L           LHA  L + HP     M + AP
Sbjct: 257 YKGNFSVFDIKKMSDELNNYLLDFNRQALHACTLQLLHPITQVQMKWNAP 306


>UniRef50_A6GP31 Pseudouridine synthase n=1 Tax=Limnobacter sp. MED105
           RepID=A6GP31_9BURK
          Length = 335

 Score =  114 bits (286), Expect = 2e-24,   Method: Compositional matrix adjust.
 Identities = 74/212 (34%), Positives = 116/212 (54%), Gaps = 11/212 (5%)

Query: 16  ILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--DYPQAESVHRLDMATSGVIVV 73
           IL++D+H++VVNKPSG+    G           R  R   +   E VHR+D  TSG++++
Sbjct: 106 ILFEDEHLLVVNKPSGMAVHGGSGSSFGLIECIRALRAETHQDLELVHRIDRETSGILII 165

Query: 74  ALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCY-ETG 132
           +  ++A R+L+ Q R R  KK Y   V GH   A   VDLPL+    +  + +V   E+G
Sbjct: 166 SKKRSALRKLQEQLRARSWKKYYKTLVLGHWPEALRQVDLPLLKTQSSEKEARVFVDESG 225

Query: 133 KPAQTEYEVVE-YAADNTARVVLKP--ITGRSHQLRVHMLALGHPILGDRFYASPE---- 185
             A T+++V++ Y +  ++  +++   +TGR+HQ+RVH  A   PI GD  Y + E    
Sbjct: 226 DKACTKFKVIQCYKSSYSSFTLIQAQILTGRTHQIRVHTSANKFPIAGDDRYGNFEMNKQ 285

Query: 186 -ARAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
            AR    R+ LHA  L + HPA   ++  +AP
Sbjct: 286 LARQGLKRMFLHAARLQLVHPATNETIVLEAP 317


>UniRef50_C0Z877 Pseudouridine synthase n=1 Tax=Brevibacillus brevis NBRC 100599
           RepID=C0Z877_BREBN
          Length = 310

 Score =  114 bits (286), Expect = 2e-24,   Method: Compositional matrix adjust.
 Identities = 77/220 (35%), Positives = 117/220 (53%), Gaps = 15/220 (6%)

Query: 4   ENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRI------QRDYPQA 57
           E  N P  P + ILY+DDH+++ NKP+G++  P  +++  D+++  +      + +    
Sbjct: 85  EGPNTPM-PSIDILYEDDHLLIANKPAGMMVHP--IKQETDTLVHALAAVLAARGEQTSV 141

Query: 58  ESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLIC 117
             VHRLD  TSG I+VA +    +   R  RE    ++Y+A   G  S   G +D P+  
Sbjct: 142 HPVHRLDKDTSGAILVAKSSYGHQLADRLLREGGIHREYLAVASGVLSEGAGTIDAPIGR 201

Query: 118 DWPNRPKQKVCYETGKPAQTEYEVVEYAADNT-ARVVLKPITGRSHQLRVHMLALGHPIL 176
           D    P ++   E+G PA T YEV + + + T ARV L+  TGR+HQ+RVH   +GHP+ 
Sbjct: 202 D-ARHPTKRRVVESGDPAITHYEVQQTSEEMTLARVWLE--TGRTHQIRVHFAHIGHPLA 258

Query: 177 GDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
           GD  Y    AR +  R  LHA  L+  HP     +  +AP
Sbjct: 259 GDTMYGG--ARGLLRRQALHASKLSFLHPLLEKEIVVEAP 296


>UniRef50_B9L028 Pseudouridine synthase n=2 Tax=Thermomicrobia (class)
           RepID=B9L028_THERP
          Length = 322

 Score =  114 bits (285), Expect = 2e-24,   Method: Compositional matrix adjust.
 Identities = 82/232 (35%), Positives = 117/232 (50%), Gaps = 21/232 (9%)

Query: 3   MENYNPPQEPW---------LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSV--MTRIQ 51
           +E Y PP EP          + ++Y+DD I+V +KP G+++ P    EH   V  +  I+
Sbjct: 68  LEVYLPPVEPPTDLEPEFLPIPVIYEDDDIIVFDKPPGIVTHPAPGHEHGTLVNALKAIR 127

Query: 52  RDYPQAES-----VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSP 106
            D     S     VHRLD  TSG++VVA T+AA   L  Q++ R   K+Y A V G   P
Sbjct: 128 PDLQVQPSHRPGIVHRLDKDTSGLLVVAKTEAARLALLEQWQSRSVVKKYTALVHGVVEP 187

Query: 107 AEGLVDLPLICDWPNRPKQKVCYETGKPAQTEYEVVE-YAADNTARVVLKPITGRSHQLR 165
             G +D P+  D   R K  V    G+PA T + V+E +       V ++  TGR+HQ+R
Sbjct: 188 DSGTIDAPISRDPVERTKMAV-VSWGRPAITHFRVLERFRCATLLDVTIE--TGRTHQIR 244

Query: 166 VHMLALGHPILGDRFYASPEARAM-APRLLLHAEMLTITHPAYGNSMTFKAP 216
           VH   +GHP++GD  Y       +  PR  LHA  L   HP  G ++  + P
Sbjct: 245 VHCAFIGHPVVGDSQYGGHRPFCVPVPRQFLHARYLRFVHPTTGQAIELETP 296


>UniRef50_Q89AH2 Ribosomal large subunit pseudouridine synthase C n=5 Tax=Buchnera
           aphidicola RepID=RLUC_BUCBP
          Length = 315

 Score =  114 bits (285), Expect = 3e-24,   Method: Compositional matrix adjust.
 Identities = 73/213 (34%), Positives = 113/213 (53%), Gaps = 9/213 (4%)

Query: 15  VILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ-AESVHRLDMATSGVIVV 73
           +ILY+D++ +++NKPSG+    G    +      RI R Y +  + VHRLD  TSGV+++
Sbjct: 94  MILYEDNYFLILNKPSGMSVHSGSGINYGMIENLRILRPYNRYLDLVHRLDRDTSGVLII 153

Query: 74  ALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYE-TG 132
           A  ++  R L  Q RE++ KK+YVA V G        +  PL+     + K  V  +  G
Sbjct: 154 AKKRSILRNLHEQLREKKIKKKYVALVHGVWPDILKSISKPLLKTSSRKNKNIVKIDPKG 213

Query: 133 KPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASP------EA 186
           K + T + + +    NT  + + PITGR+HQ+RVH+L L +PI+ D  Y         + 
Sbjct: 214 KESITHFNIKKKYTKNTL-ISITPITGRTHQIRVHLLHLNYPIVLDAKYGIKKLDYFIKN 272

Query: 187 RAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
           +    RLLLHAE +   HP    ++   AP D+
Sbjct: 273 KFNINRLLLHAESINFFHPKRKKNILITAPLDY 305


>UniRef50_A5EX53 Pseudouridine synthase n=1 Tax=Dichelobacter nodosus VCS1703A
           RepID=A5EX53_DICNV
          Length = 322

 Score =  114 bits (284), Expect = 3e-24,   Method: Compositional matrix adjust.
 Identities = 80/222 (36%), Positives = 119/222 (53%), Gaps = 24/222 (10%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES------VHRLDMAT 67
           L ILY DD I+V+NKP+GL+  P  +  H ++++  +   +PQ +       VHRLD  T
Sbjct: 86  LNILYADDDIIVINKPAGLVVHPA-VGNHDNTLLNALLYHFPQTKHLPRSGIVHRLDKDT 144

Query: 68  SGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKV 127
           SG +V+A +  A  +L RQ + R   + Y+A V+G+ +  +  +DLP+     +R K  V
Sbjct: 145 SGAMVIAHSARAHTDLVRQLQNRSMGRIYLALVYGYITAGDT-IDLPIGRHAKDRLKMAV 203

Query: 128 CYETGKPAQTEYEVVE-YAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYAS--- 183
             + GKPA T Y + E +      RV L+  TGR+HQ+RVH+    HP++GD+ Y +   
Sbjct: 204 RPD-GKPAITHYRIEERWQTLTLLRVQLE--TGRTHQIRVHLSHHRHPLVGDKLYGARPF 260

Query: 184 ---------PEARAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
                     +A A  PR  LHA  L + HPA    M F AP
Sbjct: 261 LASSLTELQRQALAEFPRQALHAVELHLHHPATNEIMRFTAP 302


>UniRef50_A7HV45 Pseudouridine synthase n=56 Tax=Alphaproteobacteria
           RepID=A7HV45_PARL1
          Length = 482

 Score =  114 bits (284), Expect = 3e-24,   Method: Compositional matrix adjust.
 Identities = 88/236 (37%), Positives = 115/236 (48%), Gaps = 34/236 (14%)

Query: 14  LVILYQDDHIMVVNKPSGLLS--VPGR--------LEEHKDSVMTRIQRDYPQAESVHRL 63
           L I+Y+D  ++VV KP+GL+    PG         L  H    ++ I  +  +   VHRL
Sbjct: 226 LEIVYEDADLIVVMKPAGLVVHPAPGNPDMTLVNALVAHCGETLSGIGGEK-RPGIVHRL 284

Query: 64  DMATSGVIVVALTKAAERELKRQF----REREPKKQYVARVWGHPSPAEGLVDLPLICDW 119
           D  TSG++VVA T  A + L  QF    R+ +  + Y A  WG P   +G VD  +    
Sbjct: 285 DKETSGLMVVAKTDRAHQGLSAQFAAHGRDGKLTRAYTALTWGVPQTRKGTVDANIARSS 344

Query: 120 PNRPKQKVCYE-----TGKPAQTEYEV-VEYAADNTARVVLKPITGRSHQLRVHMLALGH 173
            NR K     +      G+ A T Y V  +YA    A V  +  TGR+HQ+RVHM ALGH
Sbjct: 345 HNRSKMATVRDRGEETGGRIAITHYTVKTDYADGLVAEVECRLETGRTHQIRVHMTALGH 404

Query: 174 PILGDRFYA----------SPEARAMAPRL---LLHAEMLTITHPAYGNSMTFKAP 216
           P+LGD  Y           SPEA+A   RL    LHA  L   HP  G  M+F AP
Sbjct: 405 PLLGDATYGTGMKSRKSKLSPEAQAALERLNRQALHAHHLGFEHPVAGEKMSFDAP 460


>UniRef50_D1BAB3 Pseudouridine synthase n=1 Tax=Thermanaerovibrio acidaminovorans
           DSM 6589 RepID=D1BAB3_THEAS
          Length = 320

 Score =  114 bits (284), Expect = 3e-24,   Method: Compositional matrix adjust.
 Identities = 80/218 (36%), Positives = 110/218 (50%), Gaps = 14/218 (6%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES--------- 59
           PQ+    ++YQD  ++VV+KP+GL+  P         V   + R YP             
Sbjct: 91  PQDVPFRVVYQDQDLVVVDKPAGLVVHPAPGHWRGTLVHGLLYR-YPDLMELNGVKRPGI 149

Query: 60  VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDW 119
           VHRLD  TSG++VVA    A   L R F++R   K Y+A   G     EG V LP+  D 
Sbjct: 150 VHRLDATTSGLMVVARNGLAMEGLVRAFKDRRVGKVYLAMAAGTLR-GEGSVSLPIGRDP 208

Query: 120 PNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDR 179
            NR K+  C   G+ A T Y V+ ++    + V  +  TGR+HQ+RVHM +LGHP++GDR
Sbjct: 209 DNR-KRMACVPWGREALTRYRVI-WSRGGYSLVACQIKTGRTHQIRVHMRSLGHPLVGDR 266

Query: 180 FYASPEARAM-APRLLLHAEMLTITHPAYGNSMTFKAP 216
            Y  P        R+ LH+  L   HP  G  M+F  P
Sbjct: 267 IYGGPCPEGFPLGRVFLHSWRLEFDHPRTGAPMSFICP 304


>UniRef50_Q0F3G4 Pseudouridine synthase n=1 Tax=Mariprofundus ferrooxydans PV-1
           RepID=Q0F3G4_9PROT
          Length = 315

 Score =  114 bits (284), Expect = 3e-24,   Method: Compositional matrix adjust.
 Identities = 79/210 (37%), Positives = 105/210 (50%), Gaps = 9/210 (4%)

Query: 16  ILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDMATSGVIVVAL 75
           +LY+DD ++VVNKP+G++   G   E       +  R        HRLD  TSGV+++A 
Sbjct: 96  VLYEDDSLLVVNKPAGMVVHGGSGHEAGLIEALKQSRGLDDLRLAHRLDRDTSGVLLMAK 155

Query: 76  TKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVC-YETGKP 134
              A R L   FRER+ +K Y A + GHP    G +   L        ++ V   E GK 
Sbjct: 156 HLDALRRLTESFRERDMQKTYFALIAGHPYAHAGRMSSNLAKGVVRGGERMVVDSEEGKA 215

Query: 135 AQTEYEV-VEYAADNT--ARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARAM-- 189
           + T+Y+V +EY       A V L P +GR+HQLRV +   GHPILGD  Y      A   
Sbjct: 216 SVTDYQVMIEYERHGFPYAMVALNPHSGRTHQLRVQLQHEGHPILGDGKYGEKAQLAAYK 275

Query: 190 ---APRLLLHAEMLTITHPAYGNSMTFKAP 216
                 L+LHA  L  THP  G S+  KAP
Sbjct: 276 SLGGKGLMLHAWRLRFTHPVSGKSLECKAP 305


>UniRef50_A6DUC9 Pseudouridine synthase n=1 Tax=Lentisphaera araneosa HTCC2155
           RepID=A6DUC9_9BACT
          Length = 323

 Score =  114 bits (284), Expect = 3e-24,   Method: Compositional matrix adjust.
 Identities = 79/223 (35%), Positives = 113/223 (50%), Gaps = 17/223 (7%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES--------- 59
           P++  L I+Y+DD I+VVNKP+G++  PG        V   + RD     +         
Sbjct: 85  PEDIELDIIYEDDDILVVNKPAGMVVHPGAGNYTGTLVNALLGRDLDTFSAMDDGSSRPG 144

Query: 60  -VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICD 118
            VHRLD  TSGVI+VA +     +L R F  R+ +K YVA   G        +   +   
Sbjct: 145 IVHRLDKETSGVIIVAKSAKNLDKLSRSFARRDVEKYYVALCRGTIRVGRDTITSHIGRS 204

Query: 119 WPNRPKQKVCYET--GKPAQTEYEVVEYAADNTARVV-LKPITGRSHQLRVHMLALGHPI 175
             NR K +   ++  GK A + Y+V+  A +N A +V LK  TGR+HQ+RVHM  + HP+
Sbjct: 205 RSNRQKMENTNDSNRGKEAISHYKVL--ADNNGATLVKLKIDTGRTHQIRVHMSGINHPV 262

Query: 176 LGDRFYA--SPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
           +GD+ Y     + +    R +LHA    I HP     MTF AP
Sbjct: 263 VGDKLYGVRRLDEKESPDRHILHAWRTRIIHPGTQEIMTFTAP 305


>UniRef50_D2L0S2 Pseudouridine synthase, RluA family n=1 Tax=Desulfovibrio sp.
           FW1012B RepID=D2L0S2_9DELT
          Length = 558

 Score =  113 bits (283), Expect = 4e-24,   Method: Compositional matrix adjust.
 Identities = 79/224 (35%), Positives = 113/224 (50%), Gaps = 24/224 (10%)

Query: 14  LVILYQDDHIMVVNKPSGLLS--VPGRLEEHKDSVMTRIQRDYPQAES--------VHRL 63
           L +LY D  + V++KP GL     PG  E    +++ R+   +P            VHRL
Sbjct: 91  LRVLYADKELAVLDKPPGLTVHPAPGLPE---GTLVNRLLHHFPGLREMAGERPGIVHRL 147

Query: 64  DMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRP 123
           D  TSG+++VALT+     L   F  R+  K Y+A V G P    G + LP+  D   R 
Sbjct: 148 DKDTSGLLMVALTEPVRLALAADFAARQVHKTYLALVHGRPDGKGGDIRLPIGRDPKYRT 207

Query: 124 KQKVCYETGKPAQTEYEVVEYAADNTARVV-LKPITGRSHQLRVHMLALGHPILGDRFYA 182
           K  V ++ G+PA + +  V  A D TA ++ +   TGR+HQ+RVHM A+GHPI+GD  Y 
Sbjct: 208 KMAVPHKGGRPAHSRWRPVWTAPDGTASLLEVTIFTGRTHQIRVHMAAIGHPIIGDAVYG 267

Query: 183 SPEARA----------MAPRLLLHAEMLTITHPAYGNSMTFKAP 216
             +  A          +A R +LHA  L+ THP      +F  P
Sbjct: 268 PHQHAAWKRRGGAIARLASRQMLHAWKLSFTHPVLKEPRSFTCP 311


>UniRef50_B6AN83 Pseudouridine synthase n=2 Tax=Leptospirillum RepID=B6AN83_9BACT
          Length = 340

 Score =  113 bits (283), Expect = 4e-24,   Method: Compositional matrix adjust.
 Identities = 82/230 (35%), Positives = 119/230 (51%), Gaps = 24/230 (10%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVP------GRL-------------EEHKDSVMTR 49
           P++  L ILY+DD ++V++KP GL+  P      G L             E+ K      
Sbjct: 90  PEDIHLEILYEDDDLIVISKPPGLVVHPAPGHASGTLVNGLLFHFQSQGDEQKKGEPEEE 149

Query: 50  IQRDYP-QAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAE 108
            + + P +A  VHRLD  TSGV+VV  ++    +L  QF++R   K+Y+A V G      
Sbjct: 150 EEAERPLRAGLVHRLDQDTSGVMVVGKSETVVLDLMNQFKDRSVSKKYLALVKGILPKKR 209

Query: 109 GLVDLPLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHM 168
           G ++ P+     +R K  V  + GKP+ T Y V+E   +N + + +  +TGR+HQ+RVH 
Sbjct: 210 GEINAPIGRSTHDRKKFAV-RQDGKPSLTRYRVLETYHENYSLLEVTLLTGRTHQIRVHF 268

Query: 169 LALGHPILGDRFYASP--EARAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
             LG P+LGD  Y S   E R   PR +LHA  L   HP     M F+AP
Sbjct: 269 RHLGFPLLGDAVYGSKGMENRNF-PRQMLHAWKLAFQHPRSAAKMEFEAP 317


>UniRef50_C6CWL6 Pseudouridine synthase n=2 Tax=Paenibacillus RepID=C6CWL6_PAESJ
          Length = 316

 Score =  113 bits (283), Expect = 4e-24,   Method: Compositional matrix adjust.
 Identities = 72/210 (34%), Positives = 113/210 (53%), Gaps = 16/210 (7%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMT-------RIQRDYPQAESVH 61
           PQ+  L I+++DD+++VVNKP+G++  P +   H  + +        +++ +  +   VH
Sbjct: 84  PQDLPLSIVFEDDYLLVVNKPAGIIVHPTK--GHYTNTLANGIVHHWQVRGERVRFRPVH 141

Query: 62  RLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPN 121
           RLD  TSG++V+A      ++L  Q +     K Y A V+G PSPA+G V  P+  + P 
Sbjct: 142 RLDEDTSGLVVIAKNPYIHQQLSEQLQAGTIMKIYCAYVYGTPSPADGTVGAPIDRN-PE 200

Query: 122 RPKQKVCYETGKPAQTEYEVVE-YAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRF 180
            P  ++    G P+ T Y+    +     ++V LK  TGR+HQ+RVHM  +G P++GD  
Sbjct: 201 DPHVRIVTPEGYPSVTHYKTAAVFGGGQASKVRLKLETGRTHQIRVHMKHIGCPLIGDGM 260

Query: 181 YA-----SPEARAMAPRLLLHAEMLTITHP 205
           Y        E    A R  LHAE L +THP
Sbjct: 261 YGLQTGKVDEWETAAGRQALHAETLGLTHP 290


>UniRef50_Q2LWV4 Pseudouridine synthase n=1 Tax=Syntrophus aciditrophicus SB
           RepID=Q2LWV4_SYNAS
          Length = 333

 Score =  113 bits (283), Expect = 4e-24,   Method: Compositional matrix adjust.
 Identities = 80/229 (34%), Positives = 114/229 (49%), Gaps = 23/229 (10%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVP--GRLEEHKDSVMTRIQRDYPQAESV------ 60
           PQ+  L ILY+D  ++V++KP+GL+  P  G +     + +    RD      V      
Sbjct: 80  PQDIPLSILYEDHDLLVLDKPAGLVVHPAAGHVSGTLVNALLFHCRDLAGIGGVMRPGIV 139

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLD  TSG++VVA T AA + L  QF++ +  K Y A V+G P    G +DLP+     
Sbjct: 140 HRLDKDTSGLLVVAKTDAAHQGLALQFKKHQVGKTYQALVYGDPREKTGQIDLPVGRHPV 199

Query: 121 NRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRF 180
            R K       GK A T + + E     T  + +  +TGR+HQ+RVH+ A+GHP++GD  
Sbjct: 200 ERKKMSTKSRRGKEAATRWRIAERFGVATL-LNVDIVTGRTHQIRVHLAAIGHPVVGDAV 258

Query: 181 YASPEARAMA-------------PRLLLHAEMLTITHPAYGNSMTFKAP 216
           Y S + RA                R  LHA  L+ THP     + F AP
Sbjct: 259 YGSSK-RATTLTDPAVKGRLKEMSRQALHAARLSFTHPVTHKILEFHAP 306


>UniRef50_A6FJ39 Pseudouridine synthase n=1 Tax=Moritella sp. PE36
           RepID=A6FJ39_9GAMM
          Length = 238

 Score =  113 bits (282), Expect = 5e-24,   Method: Compositional matrix adjust.
 Identities = 79/213 (37%), Positives = 118/213 (55%), Gaps = 21/213 (9%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES------VHRLDMAT 67
           L ILY D+ ++V+NKP+GLLSV     E+K   +  +++    A++      VHRLD  T
Sbjct: 29  LEILYSDNDLVVINKPAGLLSVAS-ANENKQHALAILRKQLSHAKNSVALWPVHRLDRDT 87

Query: 68  SGVIVVALTKAAERELKRQFRE--REPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQ 125
           SGV++ A +    RE++    E     +K Y+A V G P P++G +D PL  D P + + 
Sbjct: 88  SGVLMFATS----REMRDAVNEGWSGAEKTYLAVVEGSPKPSQGRIDQPLRMD-PEKYQM 142

Query: 126 KVC-YETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASP 184
            V  +   K A T ++ +    + T  + +K  TGR HQ+RVHM  LGH ++GD  Y + 
Sbjct: 143 IVGPHSEAKNAVTHFKTLRTVKELTL-LEVKLETGRQHQIRVHMAWLGHSVIGDPRYGTD 201

Query: 185 EARAMAPRLLLHAEMLTITHPAYGNSMTFKAPA 217
                 PR+ LHA  L+IT P  G  +TF+APA
Sbjct: 202 -----GPRMGLHALSLSITRPNTGKRLTFEAPA 229


>UniRef50_C9M5C8 Pseudouridine synthase n=1 Tax=Jonquetella anthropi E3_33 E1
           RepID=C9M5C8_9BACT
          Length = 276

 Score =  113 bits (282), Expect = 6e-24,   Method: Compositional matrix adjust.
 Identities = 81/203 (39%), Positives = 114/203 (56%), Gaps = 19/203 (9%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ-----AESVHRLDMATS 68
           L +LY+ D ++V+NKP+GLLS P    + +DSV TR    Y       A+ VHRLD  TS
Sbjct: 49  LDVLYRSDSVLVINKPAGLLSQPD--TKGEDSVATRAL-GYASDPAFGAQLVHRLDRNTS 105

Query: 69  GVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVC 128
           GV+++AL   A R L   F+ER   K Y+A V G   P+ G +D PL+ D P++   +V 
Sbjct: 106 GVMILALDGQALRSLMVCFKERTANKTYLALVSGQLPPS-GQIDAPLLKD-PDKKLVRVA 163

Query: 129 YETGKPAQTEYEVVEYAADNTARVV-LKPITGRSHQLRVHMLALGHPILGD----RFYAS 183
              G+ A T +     A D    +  ++ +TGR+HQ+RVHM  +GHPILGD     F A 
Sbjct: 164 -SNGERAVTRFR--RLATDGQFSLAEVEILTGRTHQIRVHMNHIGHPILGDAKYGDFSAK 220

Query: 184 PEARAMAPRL-LLHAEMLTITHP 205
           P+ R +  R  +LHA  L +  P
Sbjct: 221 PQVRRLGIRRPMLHATCLVVNSP 243


>UniRef50_A8ZXZ8 Pseudouridine synthase n=1 Tax=Desulfococcus oleovorans Hxd3
           RepID=A8ZXZ8_DESOH
          Length = 329

 Score =  112 bits (281), Expect = 6e-24,   Method: Compositional matrix adjust.
 Identities = 83/232 (35%), Positives = 115/232 (49%), Gaps = 27/232 (11%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPG----------RLEEHKDSVMTRIQRDYPQAE 58
           P+   L +L++D  ++VVNKP GL+  P           RL  H  ++ T  + D P   
Sbjct: 77  PEPAPLPLLFEDAFLLVVNKPPGLVVHPAPGHEGGTLVNRLLHHFPAIGTVGEPDRPGI- 135

Query: 59  SVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICD 118
            VHRLD  TSG +VVA T AA + L   F+ R+ +K Y+A V+G      G+V LP+   
Sbjct: 136 -VHRLDRNTSGALVVAKTAAAHQALSDMFKSRQVRKTYLALVYGQMKSTGGVVTLPIGRH 194

Query: 119 WPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGD 178
              R K  V     +PA+T ++V +   D +  + L+  TGR+HQ+RVH  AL  P++GD
Sbjct: 195 SLERKKMSVSSPQARPAETRWKVRKAFVDASL-LELEIHTGRTHQIRVHCTALQRPVVGD 253

Query: 179 RFY--------------ASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
             Y              AS E    A R +LHA  L   HP  G  M F AP
Sbjct: 254 PTYPCKWTRKRQHFSSRASFELLNAAGRQMLHAWRLEFDHPVTGAPMCFTAP 305


>UniRef50_B6IQX5 Pseudouridine synthase n=1 Tax=Rhodospirillum centenum SW
           RepID=B6IQX5_RHOCS
          Length = 336

 Score =  112 bits (281), Expect = 6e-24,   Method: Compositional matrix adjust.
 Identities = 80/201 (39%), Positives = 115/201 (57%), Gaps = 8/201 (3%)

Query: 16  ILYQDDHIMVVNKPSGLLSVPGRLE-EHKDSVMTRIQRDYP-QAESVHRLDMATSGVIVV 73
           +L++D  ++V++KP+GL +  G  + +H D+++  ++ +   + + VHRLD  TSG +V+
Sbjct: 101 VLFRDHDVIVLDKPAGLATQGGTNQVKHLDAMLDALKFEAEGRPKLVHRLDKDTSGCLVL 160

Query: 74  ALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYET-G 132
           A + AA  +L   FR RE +K Y A   G P P +G +DLP+  +   R ++    E  G
Sbjct: 161 ARSAAAAAKLTAAFRSREARKIYWAVTVGVPKPMKGRIDLPVAKEAGTRGERMTVDEDEG 220

Query: 133 KPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASP----EARA 188
             A T Y V+E+A    A V L P TGR+HQLRVHM ALG PILGD  YA      E   
Sbjct: 221 VHAITYYTVLEHAHKQAAFVALWPRTGRTHQLRVHMAALGTPILGDGKYAGQGAFLEGAG 280

Query: 189 MAPRLL-LHAEMLTITHPAYG 208
             PR L LHA  + + HP  G
Sbjct: 281 DLPRQLHLHARRIILPHPRGG 301


>UniRef50_A5WFS2 Pseudouridine synthase n=3 Tax=Psychrobacter RepID=A5WFS2_PSYWF
          Length = 420

 Score =  112 bits (281), Expect = 7e-24,   Method: Compositional matrix adjust.
 Identities = 79/229 (34%), Positives = 117/229 (51%), Gaps = 20/229 (8%)

Query: 7   NPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRI-----QRDYPQAESVH 61
           + P++  L I+Y+DD ++V+NKP G++  PG        V   +     Q   P+A  VH
Sbjct: 174 DQPEDIKLDIIYEDDSVIVINKPVGMVVHPGAGNWSGTLVNGLLYHYPNQAHLPRAGLVH 233

Query: 62  RLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGH-PSPA-EGLVDLPLICDW 119
           R+D  TSG++V+  TKAA+ EL+ Q +++   + Y   V G  PS A +  +D P+    
Sbjct: 234 RIDKNTSGLLVIGKTKAAQLELQEQLKDKSVYRHYQCVVAGDAPSLARQRTIDAPIGRHR 293

Query: 120 PNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDR 179
             R K  V   TGK A T    +   +D  + + ++  TGR+HQ+RVH+  +GHPI+GD 
Sbjct: 294 TQRTKMTVT-STGKTAITHIMKITPLSDTYSLLDVRLETGRTHQIRVHLSHIGHPIIGDD 352

Query: 180 FYA---------SPEARAMA---PRLLLHAEMLTITHPAYGNSMTFKAP 216
            Y          +PE R      PR  LHA  L   HP  G S+   AP
Sbjct: 353 IYGNRQQLRAGLTPEQRQAIQSFPRQALHAYKLGFIHPETGESIELTAP 401


>UniRef50_B7HGW1 Pseudouridine synthase n=52 Tax=Bacillales RepID=B7HGW1_BACC4
          Length = 297

 Score =  112 bits (280), Expect = 9e-24,   Method: Compositional matrix adjust.
 Identities = 74/215 (34%), Positives = 117/215 (54%), Gaps = 15/215 (6%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEH-KDSVMTRIQRDYPQ---AESVH---RLDMA 66
           L I+Y+DD ++++NK + + ++P R  EH   SV   +   Y +   A +VH   RLD  
Sbjct: 82  LCIIYEDDAVLIINKEANMSTIPSR--EHPAGSVANALLSHYDKQHLASTVHIVTRLDRD 139

Query: 67  TSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQK 126
           TSG++++A  +     L +Q +++  K+ Y A V G     EG++D P+     +  ++ 
Sbjct: 140 TSGLMLIAKNRFVHHLLSKQHQQKAVKRTYEAIVHGKIVEREGMIDAPIGRKSDSIIERT 199

Query: 127 VCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEA 186
           VC E G+ A T ++V++     T  V L+  TGR+HQ+RVHM  +GHP+LGD  Y     
Sbjct: 200 VC-EDGQRAVTHFKVIDSTYHKT-HVALELETGRTHQIRVHMAHVGHPLLGDSLYGGR-- 255

Query: 187 RAMAPRLLLHAEMLTITHPAYGNSMTF--KAPADF 219
           R    R  LH++ LT  HP     M+F  K P+D 
Sbjct: 256 RDEMKRQALHSKSLTFYHPILEKEMSFTIKLPSDM 290


>UniRef50_Q30SZ1 Pseudouridine synthase n=2 Tax=Proteobacteria RepID=Q30SZ1_SULDN
          Length = 241

 Score =  112 bits (280), Expect = 9e-24,   Method: Compositional matrix adjust.
 Identities = 77/228 (33%), Positives = 113/228 (49%), Gaps = 28/228 (12%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRD------YPQAESVHRLDMAT 67
           L ILYQD+H++ +NKPSGLL     ++ H+     +  R+      YP    +HRLD  T
Sbjct: 2   LEILYQDEHLVAINKPSGLLVHRSPIDRHETEFAIQTLRNQLGRFVYP----IHRLDKPT 57

Query: 68  SGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPN------ 121
           SGV++ AL K + + +  +F   E KK Y+A V G+ +   G +D  L   +        
Sbjct: 58  SGVLLFALDKESAKIMGEKFMAHEAKKSYIAVVRGY-TLQSGEIDYALSIKFDKIADKDS 116

Query: 122 ----RPKQKVC-YETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPIL 176
                P++ +  Y+     + ++EV +Y     + V L P+TGR HQLR HM  + H IL
Sbjct: 117 SSDKEPQEALTHYKRLATVELDFEVGKYDKTRYSLVKLNPLTGRKHQLRRHMKHISHHIL 176

Query: 177 GDRFYASPEARAM------APRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           GD  Y   E   +        R+LLHA  L I+HP     +  KAP D
Sbjct: 177 GDTKYGRGEHNKLIRQEFGCHRMLLHAIALEISHPYTKELLYIKAPLD 224


>UniRef50_A4RT55 Predicted protein (Fragment) n=3 Tax=Chlorophyta RepID=A4RT55_OSTLU
          Length = 332

 Score =  112 bits (280), Expect = 1e-23,   Method: Compositional matrix adjust.
 Identities = 88/268 (32%), Positives = 126/268 (47%), Gaps = 59/268 (22%)

Query: 11  EPW--LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR-DYP--------QAES 59
           EPW  L I+++D+ ++VVNK +G+++ P    E    V   +   D P        QA S
Sbjct: 65  EPWVKLDIVHEDESVLVVNKAAGMVTHPSAGHESGTLVNAVLGHCDLPELVVPTGNQALS 124

Query: 60  -------------------------VHRLDMATSGVIVVALTKAAERELKRQFREREPKK 94
                                    VHRLD  TSGV+VVA   +A   L  QF  R  ++
Sbjct: 125 DDDEDDEDAVDEDEGARDGMIRPGIVHRLDKGTSGVMVVAKDASAHNSLCEQFAARVVRR 184

Query: 95  QYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVV- 153
           +YVA + G PSP++G ++ P+  D  +R +  V    G+ A + YEV+   A+  A +V 
Sbjct: 185 KYVAILSGVPSPSKGRIEAPIGRDPRDRLRMAVTQGGGRFAASNYEVIATLANGNASLVE 244

Query: 154 LKPITGRSHQLRVHMLALGHPILGDRFYAS-----------------PEARAMAP---RL 193
            +  TGR+HQ+RVH   +GHPILGD  Y                    EA+A+     R 
Sbjct: 245 WRLETGRTHQIRVHAKHIGHPILGDDTYGGGGGAAVSALSRYGVFDVKEAKALMSTIDRP 304

Query: 194 LLHAEMLTITHPAYGNSMTFKA--PADF 219
           +LHA  L  THP  G ++ F    P DF
Sbjct: 305 MLHARTLGFTHPQSGEALDFSRDPPEDF 332


>UniRef50_B9MS57 Pseudouridine synthase n=1 Tax=Anaerocellum thermophilum DSM 6725
           RepID=B9MS57_ANATD
          Length = 293

 Score =  112 bits (279), Expect = 1e-23,   Method: Compositional matrix adjust.
 Identities = 69/208 (33%), Positives = 114/208 (54%), Gaps = 12/208 (5%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES-----VHRL 63
           P E  + ILY+D+  + VNKPSGL S P +   + D++   ++  Y  +++     ++RL
Sbjct: 72  PVEGSIDILYEDNFFLFVNKPSGLPSHPSK-GHYFDTIANYVEY-YLNSKNLTSHIINRL 129

Query: 64  DMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRP 123
           D  TSG++V A        +  +F +R   K Y+A V G  +   GL++ P+     +  
Sbjct: 130 DKDTSGIVVFAKNSYFHSIVSYEFEKRRVDKTYIAIVHGILTKKSGLIEKPI--KRSDDG 187

Query: 124 KQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYAS 183
            ++  ++ G  A T YEV++ + +N + + LKPITGR+HQLRVH+ ++GHPI+GD  Y  
Sbjct: 188 IKREIHQDGSFASTYYEVID-SFENFSVLKLKPITGRTHQLRVHLSSIGHPIVGDYIYG- 245

Query: 184 PEARAMAPRLLLHAEMLTITHPAYGNSM 211
            E +     LLLHA  ++       N +
Sbjct: 246 -EEKTQNTPLLLHAYSISFNFKLINNKV 272


>UniRef50_Q9JVB6 Ribosomal large subunit pseudouridine synthase D n=39
           Tax=Proteobacteria RepID=RLUD_NEIMA
          Length = 374

 Score =  112 bits (279), Expect = 1e-23,   Method: Compositional matrix adjust.
 Identities = 83/225 (36%), Positives = 119/225 (52%), Gaps = 21/225 (9%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVP------GRLEEHKDSVMTRIQRDYPQAESVHR 62
           P+   L I+Y+DD ++VVNKP+GL+  P      G L     +    + +  P+A  VHR
Sbjct: 100 PEPMALDIVYEDDTVIVVNKPAGLVVHPAAGNWTGTLLNGLLAHCPELSQ-IPRAGIVHR 158

Query: 63  LDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNR 122
           LD  TSG++VVA T  A+  L  Q +ER  K+ Y A   G   P +G ++  +  D  NR
Sbjct: 159 LDKETSGLMVVAKTLPAQNSLVWQLQERTVKRIYRAVANG-IVPFDGKIETQIGRDPHNR 217

Query: 123 PKQKVCYETGKPAQTEYEVVE-YAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFY 181
            K  V    GKPA T  +V+E Y A +     L+  TGR+HQ+RVHM    HP+ GD  Y
Sbjct: 218 LKMAVVKFGGKPAVTHVKVLERYLAHSYIECSLE--TGRTHQIRVHMREANHPLAGDPVY 275

Query: 182 ASPE----------ARAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
            +P            +++  R  LHA  L+ THP  G +++F+AP
Sbjct: 276 GNPRHPCGDTVKEAVKSLGARQALHAYRLSFTHPESGETVSFEAP 320


>UniRef50_C6WV38 Pseudouridine synthase n=3 Tax=Proteobacteria RepID=C6WV38_METML
          Length = 368

 Score =  111 bits (278), Expect = 1e-23,   Method: Compositional matrix adjust.
 Identities = 85/222 (38%), Positives = 115/222 (51%), Gaps = 27/222 (12%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQ-------RDYPQAESVHRLDMA 66
           L I+Y+DDHI+VVNKP+G++  P     + D  +            D P+A  VHRLD  
Sbjct: 90  LDIVYEDDHILVVNKPAGMVVHPA--AGNWDGTLLNALLFHAPQLHDVPRAGIVHRLDKE 147

Query: 67  TSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQK 126
           TSG++VVA T  A+  L RQ + R  K++Y A VWG      G+VD PL  D  +R K  
Sbjct: 148 TSGLLVVAKTLNAQTHLVRQLQARTVKREYRAIVWGQLW-RNGVVDQPLGRDPRSRTKMA 206

Query: 127 VCYETGKPAQTEYEVVE-YAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPE 185
           +    GKPA T YE++E ++     R  L+  TGR+HQ+RVHM  L  P++GD  Y    
Sbjct: 207 IN-RMGKPAITRYEILERFSVQTYLRCNLE--TGRTHQIRVHMQHLKAPLVGDPVYGFRG 263

Query: 186 ---ARAMAPRL----------LLHAEMLTITHPAYGNSMTFK 214
               RAM   L           LHA  L + HPA    M ++
Sbjct: 264 IVPIRAMTQTLRDAVSQFHRQALHAIKLGLVHPATNEFMEWQ 305


>UniRef50_Q1Q689 Similar to ribosomal large subunit pseudouridine synthase D n=1
           Tax=Candidatus Kuenenia stuttgartiensis
           RepID=Q1Q689_9BACT
          Length = 335

 Score =  111 bits (277), Expect = 2e-23,   Method: Compositional matrix adjust.
 Identities = 74/232 (31%), Positives = 113/232 (48%), Gaps = 28/232 (12%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES--------- 59
           P++  L I+Y+DD++M++NKP  ++  P     H    +      Y Q  S         
Sbjct: 86  PEDIPLNIIYEDDYLMLINKPYDMVVHPA--GGHPSGTLVNAVTFYCQNLSQINGPLKAG 143

Query: 60  -VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICD 118
            VHRLD  TSGV++V  + A    +  QF +R  KK+Y A V G  +     +++P+   
Sbjct: 144 IVHRLDRDTSGVMLVIKSDAVHSHIAMQFEKRLVKKEYFAVVEGEVAFDSNEINMPIGRH 203

Query: 119 WPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGD 178
             +R K  V  +TGK A + YEV+E     T  V + P TGR+HQ+RVHM A+GHP++ D
Sbjct: 204 RVDRQKMAVRRDTGKNATSVYEVIERFRGYTL-VKIMPKTGRTHQIRVHMQAIGHPVVAD 262

Query: 179 RFYA---------------SPEARAMAPRLLLHAEMLTITHPAYGNSMTFKA 215
             Y+               +P+  ++  R  LHA  +   HP     M F+ 
Sbjct: 263 EMYSKYNACFRSDLLGKERAPDEGSIIERQALHAHRIEFFHPILNKQMAFQV 314


>UniRef50_D0KVM5 Pseudouridine synthase n=11 Tax=Proteobacteria RepID=D0KVM5_HALNC
          Length = 340

 Score =  110 bits (275), Expect = 3e-23,   Method: Compositional matrix adjust.
 Identities = 85/226 (37%), Positives = 116/226 (51%), Gaps = 22/226 (9%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRD-----YPQAESVHRL 63
           PQ+  L I+Y+DD I+V+NK   ++  P         V   +  D      P+A  VHRL
Sbjct: 76  PQDIPLDIIYEDDAIIVLNKSPDIVVHPAAGNPDGTLVNALLFHDPSLVSVPRAGVVHRL 135

Query: 64  DMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRP 123
           D  TSGV+VVA T AA + L      R+ +++Y   V GH   A G VD P+     +R 
Sbjct: 136 DKQTSGVMVVAKTLAAHKILVENLAARKIRREYDTVVMGH-VVAGGTVDAPIGRHPRDRQ 194

Query: 124 KQKVCYETGKPAQTEYEVVEYAADNT-ARVVLKPITGRSHQLRVHMLALGHPILGDRFYA 182
           +Q V   TGK A T Y V+++  + T  RV L+  TGR+HQ+RVHM  + HP++GD  Y 
Sbjct: 195 RQAVT-ATGKRAVTHYRVLQHYGEQTWLRVQLE--TGRTHQIRVHMAHIRHPVIGDPVYG 251

Query: 183 S-----PEARAMAPRLL-------LHAEMLTITHPAYGNSMTFKAP 216
                 P A      +L       LHA  LT+ HP  G  M F+AP
Sbjct: 252 GRPRIPPRASTALIDVLRHFERQALHARYLTLAHPVTGTQMRFEAP 297


>UniRef50_A9IQ66 Pseudouridine synthase n=5 Tax=Bacteria RepID=A9IQ66_BART1
          Length = 334

 Score =  110 bits (275), Expect = 3e-23,   Method: Compositional matrix adjust.
 Identities = 82/239 (34%), Positives = 118/239 (49%), Gaps = 37/239 (15%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGR----------LEEHKDSVMTRIQRDYPQAESVHRL 63
           L ILY+DDH++V+NKP+GL+  PG           L  H  + ++ I     +   VHRL
Sbjct: 81  LDILYEDDHVIVINKPAGLVVHPGNGNWTGTLVNALIYHCGNSLSGIG-GVKRPGVVHRL 139

Query: 64  DMATSGVIVVALTKAAERELKRQF----REREPKKQYVARVWGHPSPAEGLVDLPLICDW 119
           D  TSGV+VVA    A + L  QF    R     ++Y A +WG P      +D  L    
Sbjct: 140 DKNTSGVMVVAKNDLAHKSLSAQFSDHGRTCALDRRYHALIWGTPHRNVWTIDASLGRSP 199

Query: 120 PNRPKQKVCYET---GKPAQTEYEVVE---YAADNTARVVLKPI---TGRSHQLRVHMLA 170
            NR KQ V ++     + A T + ++E     AD+T+   L      TGR+HQ+RVHM  
Sbjct: 200 HNRTKQAVVHKQTPHARHAVTHFSLLEKYGTHADSTSFASLLECRLETGRTHQIRVHMAH 259

Query: 171 LGHPILGDRFYASP---EARAMAPRL----------LLHAEMLTITHPAYGNSMTFKAP 216
           +GHP++GD  Y +    ++  + P L           LHA  LT  HP+ G  ++F AP
Sbjct: 260 IGHPLIGDTVYGNAFKTKSNTLNPTLKNAIDQFNRHALHAASLTFEHPSSGKVISFSAP 318


>UniRef50_P65834 Ribosomal large subunit pseudouridine synthase D n=321
           Tax=Gammaproteobacteria RepID=RLUD_ECOL6
          Length = 326

 Score =  110 bits (275), Expect = 3e-23,   Method: Compositional matrix adjust.
 Identities = 81/225 (36%), Positives = 116/225 (51%), Gaps = 20/225 (8%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQ-----RDYPQAESVHRL 63
           PQ+  L I+Y+D+ I+V+NKP  L+  PG        +   +       D P+A  VHRL
Sbjct: 79  PQDIPLDIVYEDEDIIVINKPRDLVVHPGAGNPDGTVLNALLHYYPPIADVPRAGIVHRL 138

Query: 64  DMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRP 123
           D  T+G++VVA T  A+  L    + RE  ++Y A   GH + A G VD P I   P + 
Sbjct: 139 DKDTTGLMVVAKTVPAQTRLVESLQRREITREYEAVAIGHMT-AGGTVDEP-ISRHPTKR 196

Query: 124 KQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYAS 183
                +  GKPA T Y ++E+   +T R+ L+  TGR+HQ+RVHM  + HP++GD  Y  
Sbjct: 197 THMAVHPMGKPAVTHYRIMEHFRVHT-RLRLRLETGRTHQIRVHMAHITHPLVGDPVYGG 255

Query: 184 ----PEARAMA--------PRLLLHAEMLTITHPAYGNSMTFKAP 216
               P+  + A         R  LHA ML + HP  G  M + AP
Sbjct: 256 RPRPPKGASEAFISTLRKFDRQALHATMLRLYHPISGIEMEWHAP 300


>UniRef50_Q1RJX7 Ribosomal large subunit pseudouridine synthase C n=14
           Tax=Rickettsia RepID=RLUC_RICBR
          Length = 301

 Score =  110 bits (275), Expect = 4e-23,   Method: Compositional matrix adjust.
 Identities = 62/202 (30%), Positives = 106/202 (52%), Gaps = 2/202 (0%)

Query: 16  ILYQDDHIMVVNKPSGLLSVPG-RLEEHKDSVMTRIQRDYPQAESVHRLDMATSGVIVVA 74
           ++Y+DD+I+ +NKP+GL +  G ++    DS +  +       + VHRLD  TSG++++A
Sbjct: 91  LIYEDDNIIAINKPAGLATQGGSKINLSVDSALKYLNSQGADFKLVHRLDKETSGLLLIA 150

Query: 75  LTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPK-QKVCYETGK 133
               +  +L   F+E+  +K Y+A  +G P   +G V   +     + PK   +    GK
Sbjct: 151 KNYVSSVKLHDAFKEKLVEKTYLAVTYGKPIKDQGEVKTNIEKSKGSIPKITDINDNNGK 210

Query: 134 PAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARAMAPRL 193
            A T Y++++   +N   V   PITGR HQLR+H   LG PI GD  Y + +    +  +
Sbjct: 211 LAITYYKLLKSLTNNLFLVEFIPITGRMHQLRLHAKLLGCPIFGDNKYGNDKLMPYSKYM 270

Query: 194 LLHAEMLTITHPAYGNSMTFKA 215
            LHA  + ++   +G  +  +A
Sbjct: 271 FLHANNIVLSKKVFGKEVNLEA 292


>UniRef50_Q28US1 Pseudouridine synthase n=43 Tax=Rhodobacterales RepID=Q28US1_JANSC
          Length = 354

 Score =  110 bits (275), Expect = 4e-23,   Method: Compositional matrix adjust.
 Identities = 77/231 (33%), Positives = 109/231 (47%), Gaps = 32/231 (13%)

Query: 15  VILYQDDHIMVVNKPSGLLSVPGRLEE-HKDSVMTRIQ---RDYPQAESVHRLDMATSGV 70
            ++Y+DDHI+ +NKP+GL +  G  +  H D +   ++    D P+   VHRLD  TSGV
Sbjct: 98  AVIYRDDHIIAINKPAGLPTQGGTGQSRHVDGLAEALKFGLEDKPRL--VHRLDKDTSGV 155

Query: 71  IVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNR-------- 122
           +++A T+   + L   FR R  +K Y A V G P P  G + L L+   P          
Sbjct: 156 LLMARTRMGAKALTDAFRLRSTRKIYWAAVAGSPLPRMGTIKLGLV-KAPGHGRGGENEK 214

Query: 123 ----PKQKVCYETG-KPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILG 177
               P  ++    G K A+T+Y V+           L PITGR+HQLR HM  +GHPI+G
Sbjct: 215 MRAVPVDEIAQVDGAKRAETDYAVMSNLGGRVCWCALVPITGRTHQLRAHMAEIGHPIIG 274

Query: 178 DRFYASPEARAMAP------------RLLLHAEMLTITHPAYGNSMTFKAP 216
           D  Y       +              +L LHA  L+  HP  G  +   AP
Sbjct: 275 DGKYGGSGQENLGDGWGAQLGGEISRKLHLHARSLSFRHPMTGAQVNLVAP 325


>UniRef50_C0ZCK6 Pseudouridine synthase n=1 Tax=Brevibacillus brevis NBRC 100599
           RepID=C0ZCK6_BREBN
          Length = 302

 Score =  110 bits (274), Expect = 4e-23,   Method: Compositional matrix adjust.
 Identities = 78/206 (37%), Positives = 104/206 (50%), Gaps = 9/206 (4%)

Query: 16  ILYQDDHIMVVNKPSGLLSVPGRLEEH---KDSVMTRIQRDYPQAE--SVHRLDMATSGV 70
           ILY+DDH+++VNKP GLL  P     H      V     R   +A+   VHRLD  TSGV
Sbjct: 88  ILYEDDHLLIVNKPVGLLLHPTERYHHVTLDHLVSGHFFRTGLEAKVRHVHRLDQDTSGV 147

Query: 71  IVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYE 130
           ++ A    A   L    RER  K+ YVA V G      G ++ P+  D  +  +++V   
Sbjct: 148 VLYAKHPWASALLDEMLRERTIKRTYVAYVSGQMPKERGKINEPIGKDRNHGTRRRVT-P 206

Query: 131 TGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARAMA 190
            G PA T Y+V E     T +V  +  TGR+HQ+RVH   +GHP+LGD  Y     R + 
Sbjct: 207 NGDPAITHYQVKERFQTAT-KVECQLETGRTHQIRVHFSHIGHPLLGDELYGG--KRELI 263

Query: 191 PRLLLHAEMLTITHPAYGNSMTFKAP 216
            R  LHA +L   HP  G  +   AP
Sbjct: 264 KRQALHAAVLKFEHPFGGEVIEVTAP 289


>UniRef50_D1RB31 Pseudouridine synthase n=1 Tax=Parachlamydia acanthamoebae str.
           Hall's coccus RepID=D1RB31_9CHLA
          Length = 319

 Score =  110 bits (274), Expect = 4e-23,   Method: Compositional matrix adjust.
 Identities = 79/221 (35%), Positives = 114/221 (51%), Gaps = 18/221 (8%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLS--VPGR--------LEEHKDSVMTRIQRDYPQAE 58
           P++  L ILY+D+H++++NKP G++    PG         L  H    ++    D  +  
Sbjct: 82  PEQIPLNILYEDEHLLIINKPVGMVVHPAPGNWTGTFVNALLYHCGYSLSDASVDSIRPG 141

Query: 59  SVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICD 118
            VHRLD  TSGV+V A T + +++L   F  R+  K+Y A   G+P   E  ++ P I  
Sbjct: 142 IVHRLDKETSGVLVAAKTLSVQQKLMELFAARQVYKEYWAICLGNPGNCE--LNWP-IGR 198

Query: 119 WPNRPKQKVCYETGKPAQTEYEVVEYAAD-NTARVVLKPITGRSHQLRVHMLALGHPILG 177
            P   KQ    E GK A T  E +E   +   A+++L   TGR+HQ+RVH+   GHPILG
Sbjct: 199 HPIHRKQMTVREDGKEALTFCETLEVGNEICLAKLILS--TGRTHQIRVHLKHKGHPILG 256

Query: 178 DRFYASPEA--RAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
           D  Y S +   R  A R +LHA  L   HP     +  +AP
Sbjct: 257 DSIYGSKQVNMRYRAERQMLHARKLAFIHPITQQKIEVEAP 297


>UniRef50_A8MF48 Pseudouridine synthase n=12 Tax=Clostridiaceae RepID=A8MF48_ALKOO
          Length = 305

 Score =  110 bits (274), Expect = 5e-23,   Method: Compositional matrix adjust.
 Identities = 72/212 (33%), Positives = 115/212 (54%), Gaps = 14/212 (6%)

Query: 17  LYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES-------VHRLDMATSG 69
           +Y+D  +++VNK  G+++ P +   H D  +      Y +++        V+RLDM TSG
Sbjct: 89  VYEDVDLILVNKEPGIVTHPTK--SHPDWTIANGAALYLKSKGIDCKVRFVNRLDMDTSG 146

Query: 70  VIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCY 129
           ++++A    A   L  Q +E   +K+Y+A VWG     EG ++ P+     +  K +V  
Sbjct: 147 LLIIAKNAYAHHVLSEQMQEDRIEKKYIAFVWGVIKEDEGRIEAPIYRTTMDSIK-RVVD 205

Query: 130 ETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARAM 189
           E G+ + TE++V+E    N   V +K +TGR+HQ+RVHM  LGHP++GD  Y   +A  +
Sbjct: 206 ERGQESITEFKVLERYK-NATMVEVKLLTGRTHQIRVHMEHLGHPLIGDTLYGKEDAE-L 263

Query: 190 APRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
             R  LHAE L    P +  ++  KA  PAD 
Sbjct: 264 IDRQALHAEYLRFWQPRFKRAIEVKADLPADL 295


>UniRef50_C7GZW0 Pseudouridine synthase n=1 Tax=Eubacterium saphenum ATCC 49989
           RepID=C7GZW0_9FIRM
          Length = 318

 Score =  110 bits (274), Expect = 5e-23,   Method: Compositional matrix adjust.
 Identities = 66/197 (33%), Positives = 114/197 (57%), Gaps = 13/197 (6%)

Query: 17  LYQDDHIMVVNKPSGLLSVPGRLEEHKDSV------MTRIQRDYPQAESVHRLDMATSGV 70
           +Y+D+H++V++KP+G++  P    E           M  +  ++ +   ++RLDM T+G+
Sbjct: 99  VYEDEHLLVIDKPAGIVVHPTHGYEENTIAHALIHYMDTVGEEF-KIRFINRLDMDTTGL 157

Query: 71  IVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYE 130
           +++A  +  +  +  + +    +K+Y+A V G P   EG++D P I      P+++V  E
Sbjct: 158 LMIAKNQFIQNAVVSEMKRGNVEKRYLAVVHGLPCNREGIIDAP-IKAVEGEPRRQVM-E 215

Query: 131 TGKPAQTEYEVVEYAAD-NTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARAM 189
            GKP+ TEY+VV  + + N + + ++  TGR+HQ+RVH+  +G PILGD FY   E+   
Sbjct: 216 GGKPSITEYKVVGVSDELNVSFLDVRLHTGRTHQIRVHLKHIGCPILGDEFYGGKES--- 272

Query: 190 APRLLLHAEMLTITHPA 206
           A R LLH+  L  THP 
Sbjct: 273 ADRQLLHSRYLRFTHPV 289


>UniRef50_Q38VN9 Pseudouridine synthase n=1 Tax=Lactobacillus sakei subsp. sakei 23K
           RepID=Q38VN9_LACSS
          Length = 306

 Score =  109 bits (273), Expect = 5e-23,   Method: Compositional matrix adjust.
 Identities = 80/224 (35%), Positives = 113/224 (50%), Gaps = 29/224 (12%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDY---PQAES-----VHRLDM 65
           L I Y+DDH ++V+KP+ + S+P     H ++ M    + Y    QAES     V RLD 
Sbjct: 78  LKIAYEDDHFLIVDKPAFVASLPA--PNHPNNTMANFVKQYLIDEQAESLAVHVVTRLDR 135

Query: 66  ATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRP-- 123
            TSG+++      A   L RQ + +E +K Y+A   G         DLP    W +RP  
Sbjct: 136 DTSGLMMFTKHGFAHSLLDRQLQSKELQKTYIAIASGDMRE-----DLPQHA-WIDRPIK 189

Query: 124 ------KQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILG 177
                  ++V  E GK + TEY    +  D    V LK +TGR+HQ+RVH  +LGH ++G
Sbjct: 190 RSEEFYMRRVVGEGGKRSLTEYWQAAHG-DGATLVKLKLLTGRTHQIRVHFASLGHSLIG 248

Query: 178 DRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
           D  Y   E+  + PR  LH   LT  HP    ++T K+  PADF
Sbjct: 249 DNLYG--ESNDLLPRQALHCRQLTFYHPFEERTITVKSPVPADF 290


>UniRef50_D1N7N8 Pseudouridine synthase, RluA family n=1 Tax=Victivallis vadensis
           ATCC BAA-548 RepID=D1N7N8_9BACT
          Length = 323

 Score =  109 bits (273), Expect = 5e-23,   Method: Compositional matrix adjust.
 Identities = 86/218 (39%), Positives = 112/218 (51%), Gaps = 20/218 (9%)

Query: 16  ILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ-AES----------VHRLD 64
           ILY+DD ++V++KP+G++  P        +V+  +   YPQ AE           VHRLD
Sbjct: 85  ILYEDDVMLVIDKPAGVVVHPA-AGNPTGTVVNALLGRYPQLAEQLACTTSRPGIVHRLD 143

Query: 65  MATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP-NRP 123
             TSG + VA T  A+ +L   F  RE +K Y+A   G P    G +   LI   P +R 
Sbjct: 144 KDTSGCLAVAKTANAQFKLSTAFAGRETRKTYLAITRGVPIRRSGELS-TLIGRHPVSRQ 202

Query: 124 KQKVCYETGKPAQTEYEVVEYAA--DNTARVVL--KPITGRSHQLRVHMLALGHPILGDR 179
           K  V    GK A T Y V EY    D     VL  + +TGR+HQ+RVH+ +LG P+LGD 
Sbjct: 203 KMAVVERNGKLAITRYRV-EYTGMLDGVEIGVLAVRILTGRTHQIRVHLASLGVPVLGDA 261

Query: 180 FYASPE-ARAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
            Y     A A   R LLHA  L + HPA G  M F AP
Sbjct: 262 VYGGARTAVAGVERQLLHAWKLCVPHPATGTPMEFTAP 299


>UniRef50_P74346 Uncharacterized RNA pseudouridine synthase slr1629 n=19
           Tax=Bacteria RepID=Y1629_SYNY3
          Length = 327

 Score =  109 bits (273), Expect = 6e-23,   Method: Compositional matrix adjust.
 Identities = 73/216 (33%), Positives = 114/216 (52%), Gaps = 16/216 (7%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKD-SVMTRIQRDYPQAES---------VHRL 63
           L ILY+D+ ++++NKP+GL+  PG    H D +V+  +    P             VHRL
Sbjct: 98  LDILYEDEQLIIINKPAGLVVHPG--PGHPDGTVVNALLAHCPDLAGIGGVQRPGIVHRL 155

Query: 64  DMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRP 123
           D  T+G +VVA T+ A   L+ Q +E+  ++ Y   V+G P   +G V+LP+     +R 
Sbjct: 156 DKDTTGAMVVAKTELALHNLQVQLKEKTARRLYWGIVYGSPKEIQGTVNLPVGRHPGDRQ 215

Query: 124 KQKV--CYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFY 181
           K  +    + G+ A T + ++E    N + +  +  TGR+HQ+RVH   +GHP++GD  Y
Sbjct: 216 KMGIVPVEKGGREAVTHWRLLERIG-NHSWLEFQLETGRTHQIRVHSKQMGHPLVGDNLY 274

Query: 182 ASP-EARAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
            SP       P   LHA  L++ HP  G  +T  AP
Sbjct: 275 TSPGSVNVNLPGQALHAHQLSLIHPVSGEIITAIAP 310


>UniRef50_B8DF66 Pseudouridine synthase n=18 Tax=Listeria RepID=B8DF66_LISMH
          Length = 289

 Score =  109 bits (272), Expect = 7e-23,   Method: Compositional matrix adjust.
 Identities = 77/218 (35%), Positives = 113/218 (51%), Gaps = 14/218 (6%)

Query: 8   PPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR------DYPQAESVH 61
           P  E  L I+Y+DD ++VVNKP  + +      E  D+    +Q           A +VH
Sbjct: 72  PTYEYDLEIIYEDDFLLVVNKPVDMKTHANDSYE-TDTCANAVQYYLEKTGQDANALAVH 130

Query: 62  RLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPN 121
           RLD  TSG+++ A  K A   L  Q   R   + Y+A V G        ++ P+  D  +
Sbjct: 131 RLDQTTSGLVLFAKNKLAIAGLSWQMENRAIHRTYLAAVDGTWGLVMQTINKPIGEDRHH 190

Query: 122 RPKQKVCYETGKPAQTEYEVVEYAAD-NTARVVLKPITGRSHQLRVHMLALGHPILGDRF 180
             ++++    G+PA T  +V+E   + NT+ V  +  TGR+HQ+RVH+  +GHPI+GD  
Sbjct: 191 GSRRQIS-PYGQPAVTHVKVLENDNEKNTSLVECQIETGRTHQIRVHLSGIGHPIIGDTL 249

Query: 181 Y-ASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPA 217
           Y  SP A     R++LHAE L + HP  G  M F APA
Sbjct: 250 YGGSPRAN----RIMLHAEKLHLNHPFKGKEMNFSAPA 283


>UniRef50_D2QJH0 Pseudouridine synthase, RluA family n=3 Tax=Bacteria
           RepID=D2QJH0_9SPHI
          Length = 308

 Score =  109 bits (272), Expect = 7e-23,   Method: Compositional matrix adjust.
 Identities = 72/214 (33%), Positives = 109/214 (50%), Gaps = 20/214 (9%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES-------VHRLDMA 66
           L ILY+D  ++V+NK +GLLS+    E  +D     I  +Y + E+       +HRLD  
Sbjct: 89  LTILYEDQFLIVINKQAGLLSMATNKE--RDRTAYGILSEYTKKENPKNKIFIIHRLDRE 146

Query: 67  TSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQK 126
           TSGV++ A ++  +R ++  +     ++ YVA V G P P +G      I  +    K  
Sbjct: 147 TSGVMMFAKSEKVQRLMQESWNATTKERTYVALVEGIPEPPQG-----TITSYLRESKAL 201

Query: 127 VCYETGKPAQTEYEVVEYAADNT----ARVVLKPITGRSHQLRVHMLALGHPILGDRFYA 182
           + Y +  P   +  +  Y    T    A + L+  TGR +Q+RVHM  +GHP+ GD  Y 
Sbjct: 202 IVYSSQNPDTGQLSITNYTVTKTGNGYALLELELETGRKNQIRVHMQDIGHPVAGDEKYG 261

Query: 183 SPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
           + E+  +  RL LHAE+L   HP  G  M F AP
Sbjct: 262 A-ESDPIG-RLGLHAEVLAFEHPITGVPMRFDAP 293


>UniRef50_C7PP03 Pseudouridine synthase n=1 Tax=Chitinophaga pinensis DSM 2588
           RepID=C7PP03_CHIPD
          Length = 247

 Score =  109 bits (272), Expect = 7e-23,   Method: Compositional matrix adjust.
 Identities = 64/169 (37%), Positives = 95/169 (56%), Gaps = 2/169 (1%)

Query: 15  VILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDMATSGVIVVA 74
           +I+ +    +++NKP+G+L++P R +   DS+   +++ Y +  +VHRLD  TSGVI+ A
Sbjct: 6   IIIKETADFVILNKPAGMLTIPDRHDNQLDSLQGLLKKHYGEIFTVHRLDKDTSGVILFA 65

Query: 75  LTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYETGKP 134
             + A +   + F  R  KK Y   V G   P  G VD   I + P    + V    GK 
Sbjct: 66  KNEVAHKYYSQLFEGRNVKKFYKGLVNGQLHPETGSVD-EAIMEHPTIKGRMVTNRKGKN 124

Query: 135 AQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYAS 183
           AQT+Y+V+E A    + V L+  TGR+HQ+RVHM  LGHPI  D  Y +
Sbjct: 125 AQTDYQVLE-AFGLYSLVQLQIHTGRTHQIRVHMKHLGHPIAVDELYGT 172


>UniRef50_UPI0001C42CC7 hypothetical protein BpOF4_01845 n=1 Tax=Bacillus pseudofirmus OF4
           RepID=UPI0001C42CC7
          Length = 322

 Score =  109 bits (272), Expect = 8e-23,   Method: Compositional matrix adjust.
 Identities = 73/212 (34%), Positives = 110/212 (51%), Gaps = 17/212 (8%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAE-------SVHRLDMA 66
           L I Y+DDH++V+NKP G+ ++P R  EH    +      Y ++        +V+RLD  
Sbjct: 105 LDIHYEDDHLLVINKPQGMPTIPSR--EHPSRTLANAVMGYYESHHIPFTFHAVNRLDRD 162

Query: 67  TSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQK 126
           TSG++VVA    A  +L +  R  + K+ Y+A   G   P EG +  P I   P+   ++
Sbjct: 163 TSGLLVVAKHGLAHDQLSKGQRAGKLKRYYLALAEGFVQPREGTIHAP-IKRRPSSIIER 221

Query: 127 VCYETGKPAQTEYEVVEYAADNTA--RVVLKPITGRSHQLRVHMLALGHPILGDRFYASP 184
           +    G+ A T Y+V+    DN A   V +   TGR+HQ+RVH   LGHP+LGD  Y   
Sbjct: 222 MVAADGQEAITHYKVIN---DNQAYSEVEINLETGRTHQIRVHFAHLGHPLLGDDLYGG- 277

Query: 185 EARAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
            +  +  R  LH + + + HP  G  + F AP
Sbjct: 278 -SIELLARQALHCQRVELIHPFTGKHLHFSAP 308


>UniRef50_A4J1I1 Pseudouridine synthase n=1 Tax=Desulfotomaculum reducens MI-1
           RepID=A4J1I1_DESRM
          Length = 303

 Score =  109 bits (272), Expect = 8e-23,   Method: Compositional matrix adjust.
 Identities = 75/219 (34%), Positives = 117/219 (53%), Gaps = 15/219 (6%)

Query: 6   YNPPQEPWLVILYQDDHIMVVNKPSGLLSVP------GRLEEHKDSVMTRIQRD-YPQAE 58
           Y PP+   L I+ +D+ I +VNK  G+   P      G L      V   ++ +  P   
Sbjct: 75  YLPPEPLDLSIISEDEDIALVNKQPGMCVHPTLAYPSGTLAN--GLVYHWLENNPAPTFH 132

Query: 59  SVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPL-IC 117
           +V+R+D  TSG+++VA    + ++L  Q + ++  + YVA V G      G +DLPL  C
Sbjct: 133 AVNRIDRNTSGLVLVAKNSYSAQKLFLQRKRKQLARSYVALVHGKIVQRNGYIDLPLEKC 192

Query: 118 DWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILG 177
           +     +Q     TG+ A T +EV++Y  D T  + L P TGR+HQ+RVH+  LGHP++G
Sbjct: 193 EGKTTKRQ--ISSTGQQALTRFEVLQYITDCTL-IRLMPETGRTHQIRVHLSHLGHPLVG 249

Query: 178 DRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
           D  Y    + A   R  LHA+ ++  HP  G+ M+F+ P
Sbjct: 250 DTLYGG--SIAQIGRHCLHADKISFLHPRTGHPMSFQIP 286


>UniRef50_B7FU02 Predicted protein (Fragment) n=1 Tax=Phaeodactylum tricornutum CCAP
           1055/1 RepID=B7FU02_PHATR
          Length = 240

 Score =  109 bits (272), Expect = 8e-23,   Method: Compositional matrix adjust.
 Identities = 91/241 (37%), Positives = 118/241 (48%), Gaps = 36/241 (14%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPG-RLEEHKDSVMTRIQR---DYPQAESVHRLDMATSG 69
           L ILY D+HI VVNKPSG+LSVPG R      +++  I     D  Q   VHR+DM TSG
Sbjct: 1   LHILYCDEHICVVNKPSGILSVPGPRRNPSIANLVYEILNPPIDIDQM-VVHRIDMDTSG 59

Query: 70  VIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGL-VDLPLICDWPNRPKQKVC 128
           V+V ALT+ A R+L   FR R  KK Y A + GH   A  + +D+ L  D  + P  +  
Sbjct: 60  VLVFALTELALRQLHDDFRSRRVKKTYEALLAGHFRKATQVEIDVALERDPYHPPFMRRY 119

Query: 129 YETGKPAQTE------YEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYA 182
           +E  + A         Y+    A    +RV + P TGR+HQLRVH  ALG+PI+GD  Y 
Sbjct: 120 WEPQRSATYSRQFSQIYQPSAQAHLPVSRVHMSPHTGRTHQLRVHAAALGYPIIGDDIYG 179

Query: 183 ----------SPEARAMAPRLL--------------LHAEMLTITHPAYGNSMTFKAPAD 218
                     S     + P  +              LHA+ L I HP  G  M F+  A 
Sbjct: 180 FEGEGDCGVNSTILDQLIPNRMSLHQQLQELQLPLCLHAKQLCIFHPFSGAPMIFECEAP 239

Query: 219 F 219
           F
Sbjct: 240 F 240


>UniRef50_B8FT16 Pseudouridine synthase n=70 Tax=Bacteria RepID=B8FT16_DESHD
          Length = 334

 Score =  108 bits (271), Expect = 9e-23,   Method: Compositional matrix adjust.
 Identities = 74/212 (34%), Positives = 107/212 (50%), Gaps = 9/212 (4%)

Query: 14  LVILYQDDHIMVVNKPSGLLS--VPGRLEEHKDSVMTRIQRDYPQAESV------HRLDM 65
           L ILY+D+ ++VVNK  G++    PG   +   + +    R+      V      HR+D 
Sbjct: 107 LEILYEDEDVLVVNKSQGMVVHPAPGAWTKTLVNALLYHCRNLSGINGVLRPGIVHRIDK 166

Query: 66  ATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQ 125
            TSG++VVA    A + L  Q +     ++Y+A V G      G V+ P+  D  +R K 
Sbjct: 167 DTSGLLVVAKNDLAHQGLAEQIKAHSMARRYLAIVHGVVFEPSGTVEAPIGRDPADRKKM 226

Query: 126 KVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPE 185
            V ++  K A T YEV+E   D T  +  +  TGR+HQ+RVHM  L HP+LGD  Y   +
Sbjct: 227 AVVFQNAKEAVTHYEVLERFRDFTL-LEARLETGRTHQIRVHMAYLKHPVLGDPLYGPRK 285

Query: 186 ARAMAPRLLLHAEMLTITHPAYGNSMTFKAPA 217
                   +LHA++L   HP  G  M F APA
Sbjct: 286 NPFGLQGQMLHAQLLGFQHPRSGEYMEFSAPA 317


>UniRef50_A0LPH5 Pseudouridine synthase n=1 Tax=Syntrophobacter fumaroxidans MPOB
           RepID=A0LPH5_SYNFM
          Length = 344

 Score =  108 bits (271), Expect = 9e-23,   Method: Compositional matrix adjust.
 Identities = 79/238 (33%), Positives = 125/238 (52%), Gaps = 25/238 (10%)

Query: 1   MGMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSV------MTRI-QRD 53
           +G ++  P   P L IL++DD ++V+NK  G++  PG   E    V       +R+  R 
Sbjct: 75  VGEDSLQPRPMP-LEILFEDDDVLVLNKAPGVIVHPGAGHEEGTLVHGLLAHCSRLASRG 133

Query: 54  YPQAES-VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVD 112
            P+    VHRLD  TSG ++VA ++ A  EL RQF+  E  K+Y+A V+G  + A G + 
Sbjct: 134 APRRPGIVHRLDRGTSGALMVAKSERAYLELIRQFKHHEVGKEYLALVYGTMAGASGEIR 193

Query: 113 LPLICDWPNRPKQKVCYETGKPAQTEYEV-VEYAADNTARVVLKPITGRSHQLRVHMLAL 171
             +     +R +  V  + G+ A ++++V V +   +  RVV+K  TGR+HQ+RVH+  +
Sbjct: 194 TGMGRHPVDRKRMAVLEKGGREAVSQWKVAVAWGEVSLLRVVIK--TGRTHQIRVHLSHM 251

Query: 172 GHPILGDRFYASPEARAMA-------------PRLLLHAEMLTITHPAYGNSMTFKAP 216
            HP++GD  Y   + +A A              R +LHA  L   HP  G  ++F AP
Sbjct: 252 QHPVVGDETYGGGKRKARAVKSDVLRELLMEVDRQMLHAVGLAFRHPVSGADLSFTAP 309


>UniRef50_C4FWV7 Pseudouridine synthase n=2 Tax=Firmicutes RepID=C4FWV7_9FIRM
          Length = 309

 Score =  108 bits (271), Expect = 1e-22,   Method: Compositional matrix adjust.
 Identities = 77/223 (34%), Positives = 116/223 (52%), Gaps = 17/223 (7%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVP--GRLEE-------HKDSVMTRIQRDYPQAES 59
           P+   L I+Y+D+ I+V+NKP+GL+  P  G L+        H  +       D+ +   
Sbjct: 76  PEAMDLDIIYEDEDILVINKPAGLVVHPSKGHLKGTLVNGLLHYLNGNLSTGSDFYRPGI 135

Query: 60  VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDW 119
           VHR+D  TSG++VVA   AA + L  Q    + ++ Y+A V G     +G ++ PL  D 
Sbjct: 136 VHRIDKDTSGLLVVAKHNAAHQALADQLLNHDMRRSYIALVHGQVKAPQGTIEAPLQRDP 195

Query: 120 PNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDR 179
            NR +  V  E GK A T ++V+E   +N   + L+  TGR+HQ+RVH+  +GHP++GD 
Sbjct: 196 ANRLRWTVAKE-GKYALTRFQVME-NFENATLLDLELETGRTHQIRVHLEFIGHPLVGDP 253

Query: 180 FYASPEARAMAPRL------LLHAEMLTITHPAYGNSMTFKAP 216
            Y           +      LLHA  L + HP  G  + FKAP
Sbjct: 254 VYRKGLDHIKGSLVHDMTGQLLHAYALKLQHPRSGEWLEFKAP 296


>UniRef50_D2R4N0 Pseudouridine synthase, RluA family n=1 Tax=Pirellula staleyi DSM
           6068 RepID=D2R4N0_9PLAN
          Length = 313

 Score =  108 bits (270), Expect = 1e-22,   Method: Compositional matrix adjust.
 Identities = 73/211 (34%), Positives = 112/211 (53%), Gaps = 13/211 (6%)

Query: 16  ILYQDDHIMVVNKPSGLLSVP------GRLEEHKDSVMTRIQRDYPQAESVHRLDMATSG 69
           I+Y+D H++VV KP+ LL+VP      G L E   + +  + R    A  VHRLD   SG
Sbjct: 89  IVYEDRHLIVVEKPAALLTVPTPKNDRGTLLERVANYVKIVSRG-KGAFQVHRLDRGVSG 147

Query: 70  VIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCY 129
           +++   T    + L+ QF   +P+++YVA V G     EG+++  L  D           
Sbjct: 148 LLIFGKTTELAQMLRDQFAMHKPEREYVAIVRGKLDKPEGMIESFLATDRDLNRYSTDDE 207

Query: 130 ETGKPAQTEYEVV-EYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEA-- 186
             G+ A T Y V+ E A  +  +V L+  TGR +Q+RVH    GHP++GD+ Y + EA  
Sbjct: 208 SIGQHAVTHYRVIEELAGASVVQVWLE--TGRRNQIRVHFAEAGHPLIGDQRYRADEAAD 265

Query: 187 -RAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
            R    R+ LHA +L ++HP  G  + F++P
Sbjct: 266 TRWTHARIALHARLLGLSHPMTGEPLRFESP 296


>UniRef50_A6SXT6 Pseudouridine synthase n=1 Tax=Janthinobacterium sp. Marseille
           RepID=A6SXT6_JANMA
          Length = 342

 Score =  108 bits (270), Expect = 1e-22,   Method: Compositional matrix adjust.
 Identities = 75/223 (33%), Positives = 117/223 (52%), Gaps = 14/223 (6%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVP------GRLEEHKDSVMTRIQRDYPQAESVHR 62
           P+   L I+++D  ++V+NKP+GL+  P      G L       +  I    P+A  VHR
Sbjct: 110 PEAMDLAIVHEDAEMLVINKPAGLVVHPAAGNWSGTLLNGLLHYLPSIS-GVPRAGIVHR 168

Query: 63  LDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNR 122
           LD  TSG++VVA T  A  +L RQ + R  K++Y+A VWG P+   G +D  +     +R
Sbjct: 169 LDKDTSGLMVVAKTLIAHTDLVRQLQARTVKREYLALVWGTPN-ITGKIDASIGRHARDR 227

Query: 123 PKQKVCYE-TGKPAQTEYEVVEYAADN---TARVVLKPITGRSHQLRVHMLALGHPILGD 178
            K  V    T KPA T ++ +     +    + ++ +  TGR+HQ+RVHM ++G  ++GD
Sbjct: 228 IKMAVSENLTAKPAVTHFQRLATGMLDGRPVSLMLCRLETGRTHQIRVHMQSIGFALVGD 287

Query: 179 RFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
             Y       + PR  LHA  L + HP  G ++ + +  P DF
Sbjct: 288 GLYGKQHLTTVFPRQALHARRLGLIHPVSGEAVEWSSELPQDF 330


>UniRef50_Q0BYW5 Pseudouridine synthase family protein n=1 Tax=Hyphomonas neptunium
           ATCC 15444 RepID=Q0BYW5_HYPNA
          Length = 244

 Score =  108 bits (270), Expect = 1e-22,   Method: Compositional matrix adjust.
 Identities = 79/214 (36%), Positives = 120/214 (56%), Gaps = 13/214 (6%)

Query: 15  VILYQDDHIMVVNKPSGLLSVPGRL--EEHKDSVMTRIQRDYPQAESVHRLDMATSGVIV 72
           +++++D  I+  NKP G+ S  G    +   D +    + +  +   VHRLD  TSGV++
Sbjct: 21  LLIHEDAAILGFNKPPGMASQGGSSVGQSLDDLLWAFAKSNGKRPRLVHRLDQGTSGVML 80

Query: 73  VALTKAAERELKRQFREREPKKQYVARVWGHPSPAE-GLVDLPLI-CDWPNRPKQ---KV 127
            A T+ A   L   F  R+ +K Y+A V G   PAE G++D  L+  +   RP+    K 
Sbjct: 81  TARTQPAAAFLSAAFAGRDAQKTYLALVKGKLPPAEHGVIDASLVKVEEGGRPRMILAKP 140

Query: 128 CYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEAR 187
             +  +PA+T + V+    D+ A + L P TGR HQ+RVH+++LG PILGD  Y   E +
Sbjct: 141 SRKGAQPARTGWAVLARNEDH-ALMQLTPETGRMHQIRVHLMSLGCPILGDGLYG--EGQ 197

Query: 188 AMAPRLLLHAEMLTITHPAYGNSMTFKAPA--DF 219
           A APR++LHA  L + HP  G ++T +AP   DF
Sbjct: 198 ATAPRVMLHAARLEVPHP-EGGTLTLEAPVPEDF 230


>UniRef50_D1U4S9 Pseudouridine synthase, RluA family n=1 Tax=Desulfovibrio
           aespoeensis Aspo-2 RepID=D1U4S9_9DELT
          Length = 596

 Score =  108 bits (270), Expect = 1e-22,   Method: Compositional matrix adjust.
 Identities = 78/231 (33%), Positives = 113/231 (48%), Gaps = 26/231 (11%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES------------VH 61
           L ++++D H+ V++K +GL + P   E     V   + R +P   S            VH
Sbjct: 99  LEVVFEDAHVAVIDKRAGLTTHPAPGEPGPTLVNHLLHR-WPDVASDISGMDRQRPGIVH 157

Query: 62  RLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPN 121
           RLD  TSG++VVALT+     L   F  R  +K Y+A V G P+   G +D P+      
Sbjct: 158 RLDKDTSGLMVVALTEGDRLRLAADFAGRRVRKVYLAVVLGRPAQPAGTIDAPMGRHPSQ 217

Query: 122 RPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPI-TGRSHQLRVHMLALGHPILGDRF 180
           + +  V    G+ A ++Y V+       A +V   I TGR+HQ+RVHM  +GHP+LGD  
Sbjct: 218 KTRMAVVARGGREAVSDYRVLWTGPRGLASLVAVRIHTGRTHQIRVHMAHIGHPLLGDSA 277

Query: 181 YASPEA----------RAMAPRLLLHAEMLTITHPAYGNSMTF--KAPADF 219
           Y   E             +APR +LHA  L+  HPA    +T   + PADF
Sbjct: 278 YGPRENVEWSRRPDRLAGLAPRQMLHAFHLSFRHPATCERVTLWRRPPADF 328


>UniRef50_C1TRW2 Pseudouridine synthase n=1 Tax=Dethiosulfovibrio peptidovorans DSM
           11002 RepID=C1TRW2_9BACT
          Length = 305

 Score =  108 bits (270), Expect = 1e-22,   Method: Compositional matrix adjust.
 Identities = 79/214 (36%), Positives = 123/214 (57%), Gaps = 20/214 (9%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTR--IQRDYPQAESVHRLDMATSGVI 71
           LV +Y+D+ + VV+KP+GLLS P +  +  DSV+TR  +     Q ++V+RLD  TSG++
Sbjct: 79  LVTVYRDESLWVVSKPAGLLSQPDK--KGGDSVVTRAFLPGSSFQPQAVNRLDRNTSGIM 136

Query: 72  VVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYET 131
           V+ALT  + R+L  ++R+ E +K Y+A V G   P EG +D PL  D  +    KV  ++
Sbjct: 137 VLALTGESLRDLSSRWRDGEMEKVYLALVVGDL-PEEGSIDAPLSKDGSS---NKVFVDS 192

Query: 132 -GKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARAM- 189
            G+ + T Y  +  +    +  ++  ITGRSHQ+RVHM  +GHP+LGD  Y       + 
Sbjct: 193 KGQSSLTLYRRLA-SGGGLSLCLVTLITGRSHQIRVHMSHIGHPVLGDVKYGDRALNGVK 251

Query: 190 -APRLLLHAEMLTITHPAYG------NSMTFKAP 216
            A R +LHA   +++ P         +S TF+ P
Sbjct: 252 GAKRPMLHA--FSVSFPDMSGDLSSLSSKTFRTP 283


>UniRef50_P50513 Ribosomal large subunit pseudouridine synthase D n=8
           Tax=Sphingomonadales RepID=RLUD_ZYMMO
          Length = 317

 Score =  108 bits (269), Expect = 1e-22,   Method: Compositional matrix adjust.
 Identities = 79/228 (34%), Positives = 114/228 (50%), Gaps = 21/228 (9%)

Query: 6   YNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGR----------LEEHKDSVMTRIQRDYP 55
           +N PQ+  L I+++D+H++VVNKP+G++  P            L  H    ++ I     
Sbjct: 74  HNEPQDIPLEIVFEDEHLLVVNKPAGMVVHPAAGNYDNTLVNALLYHCAGKLSGIG-GVA 132

Query: 56  QAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPL 115
           +   VHR+D  TSG++VVA T  A   L  QF +    ++Y A V GHPS  +G VD PL
Sbjct: 133 RPGIVHRIDKDTSGLLVVAKTDPAHAGLAAQFADHSINRRYRAIVDGHPS-LQGHVDAPL 191

Query: 116 ICDWPNRPKQKVCYET-GKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHP 174
                NR K  +  +  GK A T Y ++     N + +  +  TGR+HQ+RVHM ++GH 
Sbjct: 192 ARSSVNRQKMAIVSDGRGKRAVTHYRMIT-PLKNASLIECRLETGRTHQVRVHMSSIGHS 250

Query: 175 ILGDRFYASPEARAMA-------PRLLLHAEMLTITHPAYGNSMTFKA 215
           +LGD  Y   +    A        R  LHA  L   HP  G  + F A
Sbjct: 251 LLGDPVYGRSKKAHHALLQSLAFQRQALHAAHLGFIHPISGKQVDFDA 298


>UniRef50_C8QZ10 Pseudouridine synthase n=1 Tax=Desulfurivibrio alkaliphilus AHT2
           RepID=C8QZ10_9DELT
          Length = 324

 Score =  108 bits (269), Expect = 2e-22,   Method: Compositional matrix adjust.
 Identities = 78/213 (36%), Positives = 105/213 (49%), Gaps = 15/213 (7%)

Query: 17  LYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES----------VHRLDMA 66
           LY+D+ I+V+ KP GL+  P   + H+   +      + +  S          VHRLD  
Sbjct: 96  LYEDEDILVLVKPPGLVVHPA--DGHRQGTLVHGLLHHCRNLSGISGQLRPGIVHRLDKD 153

Query: 67  TSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQK 126
           TSG +VVA    A   L +QF+ RE +K Y A + G  +   G V LP+     +R K  
Sbjct: 154 TSGCLVVAKNDLAHHNLVQQFKGREVEKTYQALLRGILAEDTGQVVLPIGRHPVHRKKMA 213

Query: 127 VCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEA 186
           V  E G+ A T + V +  +     V L   TGR+HQ+RVHM ALGHP+ GDR Y     
Sbjct: 214 VRREGGREAVTHWRVRQRFSAGYTLVELLLETGRTHQIRVHMAALGHPLAGDRLYGRNPE 273

Query: 187 RAM---APRLLLHAEMLTITHPAYGNSMTFKAP 216
           + M     R  LHA  L   HP  G  +TF AP
Sbjct: 274 KDMPYGIDRQWLHAWRLAFNHPRSGRRLTFTAP 306


>UniRef50_Q87AR7 Ribosomal large subunit pseudouridine synthase D n=18
           Tax=Gammaproteobacteria RepID=RLUD_XYLFT
          Length = 331

 Score =  107 bits (268), Expect = 2e-22,   Method: Compositional matrix adjust.
 Identities = 84/225 (37%), Positives = 115/225 (51%), Gaps = 20/225 (8%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRD-----YPQAESVHRL 63
           PQ+  L ILY+D+H+ V+NKP+GL+  PG        V   + RD      P+A  VHRL
Sbjct: 85  PQDIPLDILYEDEHVFVINKPAGLVVHPGAGNPDGTLVNALLHRDPALAAVPRAGVVHRL 144

Query: 64  DMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRP 123
           D  TSGV+VVA T  A+  L  Q   R+  +QY+A V      + G V+  +     +R 
Sbjct: 145 DKDTSGVMVVARTLQAQTALVEQLSSRQVHRQYLAVVVS-ALVSGGTVNAAIERHPRDRL 203

Query: 124 KQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYAS 183
           + +V  +TGK A T Y + E    +TA +  +  TGR+HQ+RVHM  L HPI+GDR Y  
Sbjct: 204 RMEVS-DTGKEAVTHYRLRERFRAHTA-LECRLDTGRTHQIRVHMAHLRHPIVGDRLYGG 261

Query: 184 ----PEARAMA--------PRLLLHAEMLTITHPAYGNSMTFKAP 216
               P+    A         R  LHAE+L   HP     +   AP
Sbjct: 262 SLKLPKGGTDALVAMLRGFKRQALHAEVLEFLHPVRALPVRIVAP 306


>UniRef50_D0LUH1 Pseudouridine synthase n=1 Tax=Haliangium ochraceum DSM 14365
           RepID=D0LUH1_HALO1
          Length = 303

 Score =  107 bits (268), Expect = 2e-22,   Method: Compositional matrix adjust.
 Identities = 69/211 (32%), Positives = 111/211 (52%), Gaps = 19/211 (9%)

Query: 12  PWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDMATSGVI 71
           P   I+++D  ++VV+KP+GLLS P   E    ++   ++    +   VHR+D+ TSG++
Sbjct: 94  PRFKIVFEDRDLVVVDKPAGLLSAPT-PESDLGNLAALLRERRERVYVVHRIDLQTSGLL 152

Query: 72  VVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYET 131
           V A T+ A + L  +FRE + ++ Y A V G P      +DLPL                
Sbjct: 153 VFAKTRRANQHLSERFREHQIERAYTAVVAGAPVEDTFTIDLPL---------------R 197

Query: 132 GKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARAMA- 190
           G+ A T  +V++   +  A +  +  TGR+HQ+R+H L  G+P+LGD  Y    +  +  
Sbjct: 198 GRRATTHLQVLQRIGERAAVLDARLETGRTHQIRLHCLQRGYPVLGDPQYGERMSDELTP 257

Query: 191 PRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
           PR+ LHA +L   HP  G +  F++  PAD 
Sbjct: 258 PRMALHARVLGFEHPRSGEARRFESELPADL 288


>UniRef50_Q83G23 Pseudouridine synthase n=2 Tax=Tropheryma whipplei
           RepID=Q83G23_TROWT
          Length = 303

 Score =  107 bits (268), Expect = 2e-22,   Method: Compositional matrix adjust.
 Identities = 73/210 (34%), Positives = 115/210 (54%), Gaps = 10/210 (4%)

Query: 14  LVILYQDDHIMVVNKPSGLLS--VPGRLEEHKDSVMTRIQRDY-PQAES--VHRLDMATS 68
           L ++Y DD + V++KP+G+ +   PG         ++ +     PQ     VHRLD  TS
Sbjct: 76  LRVIYSDDDLFVIDKPAGVAAHASPGWCGPTVTGCLSGLLAACGPQDRQGIVHRLDANTS 135

Query: 69  GVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVC 128
           G++V+A +  A   LK  FR+R   K+Y A V G+P P+ G+++ P+  D  +R +  + 
Sbjct: 136 GLMVLAKSDLAYHNLKAAFRDRAIHKRYKALVQGYPDPSSGVINAPIGRDLKHRDRFCID 195

Query: 129 YETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGD-RFYASP--E 185
           Y +G+ A T+Y   E     T  + + P TGR+HQ+RVH  AL HP++GD ++ A P   
Sbjct: 196 Y-SGRDAVTQYSTEEVYPGFTL-LSVAPKTGRTHQIRVHFSALRHPLVGDVKYGADPVFS 253

Query: 186 ARAMAPRLLLHAEMLTITHPAYGNSMTFKA 215
            +    R  LHA  L+ THP  G  + F++
Sbjct: 254 QKVNLKRQWLHAYHLSFTHPVSGVFVEFES 283


>UniRef50_Q38Y05 Pseudouridine synthase, 23S-rRNA-specific n=1 Tax=Lactobacillus
           sakei subsp. sakei 23K RepID=Q38Y05_LACSS
          Length = 296

 Score =  107 bits (268), Expect = 2e-22,   Method: Compositional matrix adjust.
 Identities = 71/220 (32%), Positives = 111/220 (50%), Gaps = 9/220 (4%)

Query: 3   MENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHK---DSVMTRIQRDYPQAES 59
           ++NY         +L++ D +++VNKP+G+ + P R  E+    + V   + +   +A  
Sbjct: 72  VQNYELDATQSFSVLFESDDLLIVNKPAGIKTHPNRPGENGTLMNQVAFYLAQQGKKAYM 131

Query: 60  VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWG--HPSPAEGLVDLPLIC 117
           VHR+D ATSG +++  T      L RQ  +++  +QY+A V    H       ++ P+  
Sbjct: 132 VHRIDEATSGTLLIGKTPIVIGILNRQLSQKKMARQYIAIVDDPKHELAEHATINSPIGV 191

Query: 118 DWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILG 177
           D  N  ++ V Y  G  A T Y V+      TA + +   TGR+HQ+RVH+ ++GHPILG
Sbjct: 192 DPENDRQRCVDYINGLSAITHYRVLSRKGA-TAVLAVDLETGRTHQIRVHLASIGHPILG 250

Query: 178 DRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPA 217
           D  Y   +     PRLLLH + L  T P      T  AP 
Sbjct: 251 DPLYNPTDT---TPRLLLHGQTLRYTEPYTDQPRTVTAPV 287


>UniRef50_A0LBW6 Pseudouridine synthase n=1 Tax=Magnetococcus sp. MC-1
           RepID=A0LBW6_MAGSM
          Length = 224

 Score =  107 bits (268), Expect = 2e-22,   Method: Compositional matrix adjust.
 Identities = 79/205 (38%), Positives = 108/205 (52%), Gaps = 10/205 (4%)

Query: 16  ILYQDDHIMVVNKPSGL--LSVPGRLEEHKDSV-MTRIQRDYPQAESVHRLDMATSGVIV 72
           IL+ D  +++ NKP+ +     PG  E   D +     +R  P A +VHRLD ATSG +V
Sbjct: 13  ILHMDADLLIFNKPNRMPIYRGPGGGETLADHLPQLCFERGKPPA-AVHRLDSATSGCLV 71

Query: 73  VALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLI-CDWPNRPKQKVCYET 131
           +   K   R L   F +   +K Y A V G P   +GL++LPL    WP RP+ KV    
Sbjct: 72  LGRHKGMRRSLSNLFAQGGVEKLYWAVVQGRPLMDQGLIELPLQDVGWPGRPRVKV-RMG 130

Query: 132 GKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARAMAP 191
           GK  +T ++V+ Y  + T  + L P TGR+HQLRVH  A+G PI+GD  Y    A    P
Sbjct: 131 GKWGRTLFQVMGYGQNETL-LALMPQTGRTHQLRVHCAAMGCPIVGDPLYGG--AACDGP 187

Query: 192 RLLLHAEMLTITHPAYGNSMTFKAP 216
            + LHA  + + H A   S T  AP
Sbjct: 188 PMHLHARRI-LLHGAIQQSFTAPAP 211


>UniRef50_Q5PAD0 Pseudouridine synthase n=5 Tax=Anaplasma RepID=Q5PAD0_ANAMM
          Length = 327

 Score =  107 bits (268), Expect = 2e-22,   Method: Compositional matrix adjust.
 Identities = 71/232 (30%), Positives = 112/232 (48%), Gaps = 20/232 (8%)

Query: 7   NPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEH---KDSVMTRIQRDYPQAES---- 59
           +P  +  L ++Y+D  ++V++K   +   PG   EH    ++++ R         S    
Sbjct: 75  SPNYDIDLKVVYEDHDVIVIDKDPYIAVHPGNGIEHHTITNALLARFGAGLQSVGSSSRP 134

Query: 60  --VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLIC 117
             VHRLD  TSG++V A T+ A   L  +   +  KK+Y+A  WG P P  G++   +  
Sbjct: 135 GIVHRLDKDTSGLMVAAKTENAYYRLSEELANQGFKKEYLAVAWGIPCPKRGVIHTNIRV 194

Query: 118 DWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILG 177
              +    +     GKPA+TEYEV +   +  + +     TGR+HQ+RVHM  +GH I+G
Sbjct: 195 KRSDITMMEAANSGGKPAKTEYEVEQELGEVASLIRCTLHTGRTHQIRVHMSHIGHSIVG 254

Query: 178 DRFYASPEARAMAP----------RLLLHAEMLTITHPAYGNSMTFKA-PAD 218
           D+ Y     + M            R  LHA +L   HP+ G  + F + PAD
Sbjct: 255 DQKYGKNCKKCMRSGVPPDVKNFRRQALHASLLGFRHPSTGKYIEFTSKPAD 306


>UniRef50_Q211J3 Pseudouridine synthase n=81 Tax=Alphaproteobacteria
           RepID=Q211J3_RHOPB
          Length = 501

 Score =  107 bits (268), Expect = 2e-22,   Method: Compositional matrix adjust.
 Identities = 79/212 (37%), Positives = 106/212 (50%), Gaps = 11/212 (5%)

Query: 15  VILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES--VHRLDMATSGVIV 72
           +ILY+D  +MV+NKP+GL    G        +M  + RD    +   VHRLD  T+G ++
Sbjct: 263 MILYEDADVMVLNKPAGLAVQGGSGTTRHVDLMLEVMRDAKGQKPRLVHRLDKETAGCLL 322

Query: 73  VALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYETG 132
           +A T+ A   L   FRER  +K Y A V G P P +G +   L  +           E G
Sbjct: 323 IAKTRFAATALTGAFRERSARKVYWALVAGVPKPKQGRISTYLAKEESEDDTIMRIAEHG 382

Query: 133 KP----AQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEA-- 186
                 A T Y VVE +A   A V LKP+TGR+HQLR HM  +GH I+GD  Y + E   
Sbjct: 383 DEGASHAVTYYAVVETSASKLAWVSLKPVTGRTHQLRAHMAHIGHAIVGDPKYFNIENWQ 442

Query: 187 --RAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
               +  RL L A  + I HP  G ++   AP
Sbjct: 443 LPGGLQNRLHLLARRIVIPHP-RGGTIDVSAP 473


>UniRef50_A9B3Z2 Pseudouridine synthase n=1 Tax=Herpetosiphon aurantiacus ATCC 23779
           RepID=A9B3Z2_HERA2
          Length = 560

 Score =  107 bits (267), Expect = 3e-22,   Method: Compositional matrix adjust.
 Identities = 75/208 (36%), Positives = 113/208 (54%), Gaps = 13/208 (6%)

Query: 16  ILYQDDHIMVVNKPSGLLSVPGR----LEEHKDSVMTRIQRDYPQAESVH-RLDMATSGV 70
           ILY+D+ I+V+NKP+G+ +   +    L + + ++  ++Q +Y    ++H RLD  TSGV
Sbjct: 5   ILYRDEQILVINKPTGVATHAPQGDLALTDVERALRAQLQLEYL---AIHQRLDRDTSGV 61

Query: 71  IVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYE 130
           ++ AL  AA   L   F E   +K Y A V+G P   +G++D  L        +    ++
Sbjct: 62  MLFALDPAANANLATAFAEHTIEKTYQALVYGVPIQTQGVIDAALAPAGDGMIQVASAHD 121

Query: 131 T-GKPAQTEYEVVEYAADNTARVV-LKPITGRSHQLRVHMLALGHPILGDRFYASPEARA 188
              + A T Y V+  + D    ++ L+P TGR+HQLRVH   LGHPI+GD  Y    A  
Sbjct: 122 RRAQSAITHYRVLVSSPDQRFSLLELQPKTGRTHQLRVHCECLGHPIVGDPLYDVARA-- 179

Query: 189 MAPRLLLHAEMLTITHPAYGNSMTFKAP 216
            APRL+LHA  L  THP     +  +AP
Sbjct: 180 -APRLMLHASELRFTHPLTQQPLHIQAP 206


>UniRef50_Q312A0 Pseudouridine synthase, RluD n=6 Tax=Bacteria RepID=Q312A0_DESDG
          Length = 578

 Score =  107 bits (267), Expect = 3e-22,   Method: Compositional matrix adjust.
 Identities = 76/236 (32%), Positives = 116/236 (49%), Gaps = 27/236 (11%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES--------V 60
           P+E  L +LY+D H++V+NKP+GL   P      + +++ R+   +P+ E+        V
Sbjct: 114 PEEGELEVLYRDAHMLVINKPAGLTVHPAP-SCPEGTLVHRLLHHFPELEAQEGFRPGIV 172

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HR+D  TSG++++ALT+ A   L   F  R   K+Y+A V G P    G +D P +   P
Sbjct: 173 HRIDKDTSGLLLIALTEKARLALSDAFAGRRIHKEYLALVKGIPEGDSGEIDAP-VGRHP 231

Query: 121 NRPKQKVCYETGKPAQTEYEVV---EYAADNTA--RVVLKPITGRSHQLRVHMLALGHPI 175
               +      G+ A + + V+    +    T    V ++  TGR+HQ+RVHM   GHP+
Sbjct: 232 THKTRMAVVRGGREALSTWRVLLADPHGGGGTGWTLVAVRIHTGRTHQIRVHMQHTGHPL 291

Query: 176 LGDRFYA----------SPEARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
            GD  Y           +P     A R +LHA  ++  HP  G  M F    PADF
Sbjct: 292 WGDALYGGMPGREELQTTPALAQTATRQMLHAWKISFDHPVTGAPMQFTLPPPADF 347


>UniRef50_B5YKV0 Pseudouridine synthase n=1 Tax=Thermodesulfovibrio yellowstonii DSM
           11347 RepID=B5YKV0_THEYD
          Length = 315

 Score =  107 bits (267), Expect = 3e-22,   Method: Compositional matrix adjust.
 Identities = 70/223 (31%), Positives = 118/223 (52%), Gaps = 20/223 (8%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKD-SVMTRIQRDYPQAESV------- 60
           PQ   + ++Y+DD+++V++KP+G++  P     H D ++M  +     +  +V       
Sbjct: 77  PQNIPIQVIYKDDYLIVLSKPAGMVVYP--CAGHPDGTLMNALAYHVKKLANVGAPFRPG 134

Query: 61  --HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICD 118
             HRLD  TSGV+VVAL      +L   F++RE KK+Y+A V+G      G +  P+   
Sbjct: 135 IVHRLDKDTSGVMVVALDDETYYKLVEAFKKREIKKEYLALVYGQLR-GSGKITTPVGRA 193

Query: 119 WPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGD 178
             +R K  +  +  K A TE+EV++    N   + +K +TGR+HQ+RVH  ++GHP++GD
Sbjct: 194 IYDRKKMSIKSKKAKEAITEWEVIK-NFKNYTFLKVKILTGRTHQIRVHFSSIGHPVIGD 252

Query: 179 RFYASP------EARAMAPRLLLHAEMLTITHPAYGNSMTFKA 215
           + Y           +    R +LHA  + + HP     + F+A
Sbjct: 253 KTYGRKTYIEIGNKKIPVSRQMLHAHKIELIHPITEKLLQFEA 295


>UniRef50_B5JHH9 Pseudouridine synthase n=1 Tax=Verrucomicrobiae bacterium DG1235
           RepID=B5JHH9_9BACT
          Length = 324

 Score =  107 bits (267), Expect = 3e-22,   Method: Compositional matrix adjust.
 Identities = 79/233 (33%), Positives = 117/233 (50%), Gaps = 24/233 (10%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDY-----PQAES---- 59
           P+ P   I+Y D+HI+VVNK +GL++VP   E  +   + R+  DY     P A++    
Sbjct: 82  PKIPDAAIVYFDEHIVVVNKAAGLMTVP-HPESDETETLDRLVNDYLRIRDPDAKTNRAS 140

Query: 60  ---VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDL--- 113
              VHR+D  TSG++V A T  A+R L  QFR    +++Y+A V G          L   
Sbjct: 141 LGVVHRIDKDTSGLVVFARTFLAKRALSEQFRAHSIERRYLAIVHGELKAQSIRTHLVRE 200

Query: 114 ---PLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLA 170
               L    P         E G+ A T  +VVE  A  T  V  +  TGR+HQ+R+H+  
Sbjct: 201 TGDGLRGSAPKGATNSEGEELGRLAITHVDVVERLAGATL-VSCRIETGRTHQIRIHLSE 259

Query: 171 LGHPILGDRFYASPEARAMAP--RLLLHAEMLTITHPAYGNSMTFK--APADF 219
           +GHPI+G++ Y       + P  R +LHA  L   HP  G +++++  A  DF
Sbjct: 260 IGHPIVGEKVYIRGFEGELIPANRAMLHAAELGFIHPGSGEAVSWQEEASKDF 312


>UniRef50_Q8ZFU1 Ribosomal large subunit pseudouridine synthase C n=102
           Tax=Gammaproteobacteria RepID=RLUC_YERPE
          Length = 320

 Score =  107 bits (267), Expect = 3e-22,   Method: Compositional matrix adjust.
 Identities = 75/212 (35%), Positives = 110/212 (51%), Gaps = 12/212 (5%)

Query: 16  ILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQA---ESVHRLDMATSGVIV 72
           IL++DD+++V+NKPSG     G        V+  ++   P+A   E VHRLD  TSGV++
Sbjct: 95  ILFEDDYLLVLNKPSGTAVHGG--SGLSFGVIEGLRALRPEARFLELVHRLDRDTSGVLL 152

Query: 73  VALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYET- 131
           VA  ++A R L  Q R +  +K Y+A V G        +  PL+ +     ++ V   + 
Sbjct: 153 VAKKRSALRSLHEQLRLKSMQKDYLALVRGQWQSHCKAIQAPLLKNIMQSGERVVKVSSE 212

Query: 132 GKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARAMAP 191
           GKP++T ++ +E   ++   V   P+TGR+HQ+RVH L  GHPI  D  Y   E      
Sbjct: 213 GKPSETRFK-IEERFEHATLVKASPVTGRTHQIRVHALHAGHPIAFDDRYGYREFDQQLQ 271

Query: 192 -----RLLLHAEMLTITHPAYGNSMTFKAPAD 218
                RL LHA  L   HP  G +M  +AP D
Sbjct: 272 GTGLHRLFLHAAALRFEHPNTGETMRIEAPLD 303


>UniRef50_D1Y726 Ribosomal large subunit pseudouridine synthase D n=1
           Tax=Pyramidobacter piscolens W5455 RepID=D1Y726_9BACT
          Length = 315

 Score =  107 bits (267), Expect = 3e-22,   Method: Compositional matrix adjust.
 Identities = 91/231 (39%), Positives = 130/231 (56%), Gaps = 26/231 (11%)

Query: 3   MENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTR-----IQRDYPQA 57
           M +  P + P L ++Y D  +MVVNKP+GLLS P    E  DSV+TR     +  ++P  
Sbjct: 75  MPDGTPRRLP-LDVIYSDRCVMVVNKPAGLLSQPDVKGE--DSVVTRALGYAVDPEFP-P 130

Query: 58  ESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLIC 117
           + VHRLD  TSGV+ +AL     R L   F+ R   K+Y A V G   P  G +D+PL+ 
Sbjct: 131 QLVHRLDRNTSGVMALALDGPTTRALMECFKARRADKRYWAIVIGE-LPERGRIDVPLLK 189

Query: 118 DWPNRPKQKVCYE-TGKPAQTEYE-VVEYAADNTARVVLKPITGRSHQLRVHMLALGHPI 175
           D     K+ V  +  G+ A TEY+ +    A + A V L  +TGR+HQ+RVHM  +GHP+
Sbjct: 190 D---ADKKLVRVDPKGERAVTEYKRLTSSGAFSLAEVHL--LTGRTHQIRVHMNHVGHPL 244

Query: 176 LGD----RFYASPEARAMA-PRLLLHAEMLTITH-PAYGNSM---TFKAPA 217
           LGD     F +  + R++   R +LHA  LT+   PA+ + +   TF+APA
Sbjct: 245 LGDVKYGDFGSKGQLRSLGVKRPMLHARSLTLNGLPAFLSHLEGKTFRAPA 295


>UniRef50_Q47417 tRNA pseudouridine synthase C n=252 Tax=cellular organisms
           RepID=TRUC_PECCC
          Length = 376

 Score =  107 bits (266), Expect = 3e-22,   Method: Compositional matrix adjust.
 Identities = 80/224 (35%), Positives = 111/224 (49%), Gaps = 20/224 (8%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDY--PQAESVHRLDMATSGVI 71
           L I+YQD+H++ VNKPSG L     L+  +  V+ +  RD       +VHRLD  TSGV+
Sbjct: 116 LEIIYQDEHLVAVNKPSGWLVHRSWLDRKEKVVVMQTVRDQIGQHVYTVHRLDRPTSGVL 175

Query: 72  VVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPL------ICDW---PNR 122
           ++AL+    R L +QF   + +K Y A V G+    +G++D  L      I D    P++
Sbjct: 176 LLALSSEVARALSQQFESHQMQKTYHAVVRGY-VLDDGVIDYALTEELDKIADKFTNPDK 234

Query: 123 PKQKVCYETGKPAQTEYEVV--EYAADNTARVVLKPITGRSHQLRVHMLALGHPILGD-- 178
             Q         AQ E  V    Y     + + LKP TGR HQLR HM  + HPI+GD  
Sbjct: 235 APQPAVTHYRSLAQAEMPVAIGRYPTARYSLMELKPQTGRKHQLRRHMSHIHHPIIGDTA 294

Query: 179 ----RFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
               R     E+     RL+LHA  L + HP  G  +T +A  D
Sbjct: 295 HGDLRHNRGMESHFSCGRLMLHASELQLNHPVSGQPLTLQARWD 338


>UniRef50_C7LR44 Pseudouridine synthase n=6 Tax=Bacteria RepID=C7LR44_DESBD
          Length = 243

 Score =  107 bits (266), Expect = 3e-22,   Method: Compositional matrix adjust.
 Identities = 76/213 (35%), Positives = 108/213 (50%), Gaps = 14/213 (6%)

Query: 12  PWLVILYQDDHIMVVNKPSGLLSVPGRLEEHK-------DSVMTRIQRDYPQAESVHRLD 64
           P LVI+Y+D  I+VVNKP+G+L++    E+ +       D V     +   +   VHRLD
Sbjct: 14  PGLVIIYEDRDIIVVNKPAGMLTMATETEKTRTAYYALTDYVRKGNAKSRYRIFIVHRLD 73

Query: 65  MATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPK 124
             TSG+++ A T+ A+R L+ Q+ +    K Y A V G    A G++   L+    ++  
Sbjct: 74  RETSGIVLFAKTEVAKRTLQDQWED--TTKIYAAVVHGQMGKASGMLSSHLVESGVHKVY 131

Query: 125 QKVCYETGKPAQTEYEVV-EYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYAS 183
                  GK A+T + V+ E    +   V L  +TGR HQ+RV M   GHPI GD+ Y  
Sbjct: 132 ATRDAALGKLARTAWTVLKERGGYSLLDVTL--LTGRKHQIRVQMADAGHPIAGDKKYGV 189

Query: 184 PEARAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
                   RL LHA  +T  HP  G SMT  AP
Sbjct: 190 KG--DTFSRLALHARSITFAHPFSGRSMTLDAP 220


>UniRef50_O31613 Uncharacterized RNA pseudouridine synthase yjbO n=53
           Tax=Bacillaceae RepID=YJBO_BACSU
          Length = 283

 Score =  107 bits (266), Expect = 4e-22,   Method: Compositional matrix adjust.
 Identities = 75/210 (35%), Positives = 105/210 (50%), Gaps = 13/210 (6%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVH-------RLDMA 66
           L ILY+D+H++V+NK   + S+P R  EH    +     D+ Q   V        RLD  
Sbjct: 66  LDILYEDEHVLVINKQPYVSSIPSR--EHPSGSIANGIIDHYQTTGVRATVHLVTRLDRD 123

Query: 67  TSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQK 126
           TSG+++VA  + A   L    +    K++Y A V G  +  EG VD P I   P+   ++
Sbjct: 124 TSGIMLVAKHRFAHSILSSAQKNGLVKRRYAAVVHGRMAQMEGTVDAP-IGRHPDSIIER 182

Query: 127 VCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEA 186
                G+ A T +  V  A D+   V L+  TGR+HQ+RVHM  LGHP+ GD  Y     
Sbjct: 183 TVTPDGQKAVTHF-YVTCANDDMTSVALQLETGRTHQIRVHMSYLGHPLCGDTLYGG--T 239

Query: 187 RAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
           R    R  LH+E L+  HP    +M F AP
Sbjct: 240 RQEIGRQALHSEHLSFIHPLTQENMRFHAP 269


>UniRef50_Q5QZ45 Pseudouridine synthase n=2 Tax=Gammaproteobacteria
           RepID=Q5QZ45_IDILO
          Length = 315

 Score =  107 bits (266), Expect = 4e-22,   Method: Compositional matrix adjust.
 Identities = 73/210 (34%), Positives = 108/210 (51%), Gaps = 8/210 (3%)

Query: 16  ILYQDDHIMVVNKPSGLLSVPGR-LEEHKDSVMTRIQRDYPQAESVHRLDMATSGVIVVA 74
           ILY+DD +M++NKPSG+    G  L+      +  ++      E VHR+D  TSG+++VA
Sbjct: 94  ILYEDDALMLINKPSGVAVHGGSGLQFGLIEGLRALRPKEKSLELVHRIDRDTSGLLLVA 153

Query: 75  LTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYET-GK 133
             ++  R L  Q R +E  KQY+A V G        V+ PL  +     ++ V  +  GK
Sbjct: 154 KKRSVLRSLHEQLRNKEMNKQYLALVRGQWQKRVRSVEAPLKKNTLKSGERIVRVDAEGK 213

Query: 134 PAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPI-----LGDRFYASPEARA 188
            + T + + +   + T  V   P+TGR+HQ+RVH L  GHPI      GD  + +  +R 
Sbjct: 214 ASLTRFRIQQRYKEGTL-VEASPVTGRTHQIRVHALHAGHPIAKDPKYGDTDFDNTMSRL 272

Query: 189 MAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
              RL LHA  L   HP  G  + F+AP D
Sbjct: 273 GLNRLFLHAWQLRFLHPVTGKEVAFEAPLD 302


>UniRef50_C9KPZ8 Pseudouridine synthase n=1 Tax=Mitsuokella multacida DSM 20544
           RepID=C9KPZ8_9FIRM
          Length = 308

 Score =  107 bits (266), Expect = 4e-22,   Method: Compositional matrix adjust.
 Identities = 79/220 (35%), Positives = 113/220 (51%), Gaps = 16/220 (7%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGR-----------LEEHKDSVMTRIQRDYPQA 57
           P++  L ILY+D  I+V+NK  G++  P             L   KD  ++ I  +  + 
Sbjct: 75  PEDIPLDILYEDSDIIVINKARGMVVHPATGIYTGTLVNALLYHCKD--LSGINGEI-RP 131

Query: 58  ESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLIC 117
             VHRLD  TSGV+V A   AA  +L  Q R +   + Y A V G+     G++   +  
Sbjct: 132 GIVHRLDKDTSGVMVAAKNDAAHLDLAEQIRTKAAHRIYRAIVCGNIREEAGVIKGDIGR 191

Query: 118 DWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILG 177
              +R K  + +E GKPA T + V+E     T  V  +  TGR+HQ+RVHM ++GHP+LG
Sbjct: 192 HPTDRKKMAIVHEHGKPAVTHFRVLERFGAYTL-VECRLETGRTHQIRVHMASIGHPVLG 250

Query: 178 DRFYASPEARAMAPR-LLLHAEMLTITHPAYGNSMTFKAP 216
           D  Y   +A   A +   LH+  LT+THP     MTF AP
Sbjct: 251 DPKYGPRKACPFAIKGQALHSLQLTLTHPRTREVMTFTAP 290


>UniRef50_D1RB93 Pseudouridine synthase n=1 Tax=Parachlamydia acanthamoebae str.
           Hall's coccus RepID=D1RB93_9CHLA
          Length = 283

 Score =  107 bits (266), Expect = 4e-22,   Method: Compositional matrix adjust.
 Identities = 72/206 (34%), Positives = 104/206 (50%), Gaps = 10/206 (4%)

Query: 16  ILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP-QAESVHRLDMATSGVIVVA 74
           ILY+D H++V+ KP+GLLSV    ++ K +     +R  P +   VHRLD  TSGV++ A
Sbjct: 70  ILYEDAHLVVIEKPAGLLSVATNFDKAKTAHAFLKERYRPRKVYVVHRLDQDTSGVMLFA 129

Query: 75  LTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYETGKP 134
           LT  A   LK  F + +  ++Y A V G  +  EG     L  D     K  V + T  P
Sbjct: 130 LTGEAFFGLKALFADHDIDREYTAVVHGKMTQQEGTWQSYLYED-----KAYVVHSTQDP 184

Query: 135 AQTEYEVVEY----AADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARAMA 190
            + E  +  +    A  + + + LK  TG+ +Q+RVH    G PI+GD+ Y       + 
Sbjct: 185 DKGELAITHFKTVEARTHFSLLNLKLETGKKNQIRVHCEDHGFPIVGDKKYGGEGESHIT 244

Query: 191 PRLLLHAEMLTITHPAYGNSMTFKAP 216
            RL LHA  L   HP Y   M+F +P
Sbjct: 245 KRLCLHAHHLGFVHPIYKKEMSFDSP 270


>UniRef50_C8PW17 Pseudouridine synthase n=5 Tax=Moraxellaceae RepID=C8PW17_9GAMM
          Length = 365

 Score =  107 bits (266), Expect = 4e-22,   Method: Compositional matrix adjust.
 Identities = 75/219 (34%), Positives = 112/219 (51%), Gaps = 18/219 (8%)

Query: 16  ILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDMATSGVIVVAL 75
           I+Y+D+ ++V+NKPSG+    G  E        R        E VHR+D  TSG++++A 
Sbjct: 141 IVYEDEGLIVLNKPSGMAVHGGSGESFGVIEAMREATGKKYLELVHRIDKDTSGLLMIAK 200

Query: 76  TKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLIC----------DWPNRPKQ 125
            ++  + L+   RE+  +K Y+  V G  S     +D PL+               R K 
Sbjct: 201 KRSTLKTLQEHLREKTLQKTYLCLVVGWISSETQTIDKPLLKYTLPATQEGKSGERRVKV 260

Query: 126 KVCYETGKPAQTEYEVVEYAADNTARVVL---KPITGRSHQLRVHMLALGHPILGDRFYA 182
            V  E  KP+QT+  V++    N  +V L   KP+TGR+HQ+RVH+ ++GHP+LGD  Y 
Sbjct: 261 DVKSEDSKPSQTQINVLQKFELNGQKVSLIEAKPLTGRTHQIRVHLASIGHPLLGDDKYN 320

Query: 183 SPEARA--MAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
              A+   M  RL LHA  L I  P Y  ++T + P D 
Sbjct: 321 PNVAKGDKMVRRLCLHAYQLAI--PEY-ETITAELPVDM 356


>UniRef50_B8FLB4 Pseudouridine synthase n=2 Tax=Bacteria RepID=B8FLB4_DESAA
          Length = 321

 Score =  107 bits (266), Expect = 4e-22,   Method: Compositional matrix adjust.
 Identities = 83/232 (35%), Positives = 114/232 (49%), Gaps = 31/232 (13%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLS--VPGR---------LEEHKD-SVMTRIQRDYPQA 57
           Q+  L ILY+D  I+ VNKP G++    PG          L   KD S +  +QR     
Sbjct: 79  QDMDLAILYEDRDIVAVNKPPGMVVHPAPGHSSNTLVNALLAHCKDLSGIGGVQR----P 134

Query: 58  ESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLIC 117
             VHRLD  TSGVI+ A   AA   L  Q  +R  +K Y+A   G      G++DLPL  
Sbjct: 135 GIVHRLDKETSGVILAAKNDAAHAGLSEQLAQRRVEKFYLALAHGVIKEDTGVIDLPLAR 194

Query: 118 DWPNRPKQKVCY-ETGKPAQTEYEVVEYAADNT-ARVVLKPITGRSHQLRVHMLALGHPI 175
              +R +  V     G+ A + + V E   D T  +V +K  TGR+HQ+RVH+ AL HP+
Sbjct: 195 HPSDRKRMHVSTPAKGREALSLWTVKERFLDATYVKVQIK--TGRTHQIRVHLAALHHPV 252

Query: 176 LGDRFYASPEARAMAP-----------RLLLHAEMLTITHPAYGNSMTFKAP 216
           +GD  Y   + R   P           R +LHA +++ THP  G  +T  AP
Sbjct: 253 IGDTVYGGRKKRGRLPASVLGKAPPPERQMLHAHIVSFTHPVTGEKLTLTAP 304


>UniRef50_Q5Z213 Pseudouridine synthase n=2 Tax=Actinomycetales RepID=Q5Z213_NOCFA
          Length = 260

 Score =  106 bits (265), Expect = 5e-22,   Method: Compositional matrix adjust.
 Identities = 70/209 (33%), Positives = 110/209 (52%), Gaps = 26/209 (12%)

Query: 16  ILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDMATSGVIVVAL 75
           +L +DD ++ +NKP+G+ SV G  E H   ++        +   VHR+D  TSG++++A 
Sbjct: 13  LLAEDDAVLALNKPAGI-SVTG--ERHDTDIVELAAGAGERLFPVHRIDKVTSGLVLLAK 69

Query: 76  TKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNR-----PKQKVCYE 130
             AA   L RQF +R  +K Y+A V G   P  G+++LPL     NR     P++ +  E
Sbjct: 70  DLAAHGTLTRQFTKRTAEKAYLAVVAGGGLPDRGVIELPLSVGRKNRVRIAAPRESIRAE 129

Query: 131 TGK--------------PAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPIL 176
            G+              P++TE+  +   AD T  + L+P+TGR HQ+RVH+  +GH I+
Sbjct: 130 DGRWFVDDADLLAVKNYPSRTEFVTLARTADRTV-LALRPVTGRRHQIRVHLAWIGHAIV 188

Query: 177 GDRFYASPEARAMAPRLLLHAEMLTITHP 205
           GD  +   +  A  PR  LH+  L +  P
Sbjct: 189 GDPLF---DKSAAHPRAHLHSWRLVLDAP 214


>UniRef50_C6VIZ5 Pseudouridine synthase n=3 Tax=Lactobacillus plantarum
           RepID=C6VIZ5_LACPJ
          Length = 300

 Score =  106 bits (265), Expect = 5e-22,   Method: Compositional matrix adjust.
 Identities = 77/216 (35%), Positives = 111/216 (51%), Gaps = 6/216 (2%)

Query: 4   ENYNPPQEPWLVILYQDDHIMVVNKPSGLLS---VPGRLEEHKDSVMTRIQRDYPQAESV 60
            NY         ILYQ+  ++VV+KP+G+ S    PG      + +   +Q        V
Sbjct: 74  SNYIAAATAPATILYQNSDLLVVDKPAGVKSHPNQPGETGSILNDLAATLQPTQQVPYMV 133

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLD  TSG ++VAL       L R   +++ ++ Y A V GH +   G    P+  D  
Sbjct: 134 HRLDQMTSGAMLVALNPVVVPILDRLISDKQIRRTYYAWVRGHFATPTGHFTAPIGHDAT 193

Query: 121 NRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRF 180
           ++ K+ V     +PA T+YEV    A  +  V L   TGR+HQLRVH+ A  HPI+GD  
Sbjct: 194 DKRKRWVNTADAQPALTDYEVCATTAHQSL-VKLTLHTGRTHQLRVHLAASDHPIIGDPL 252

Query: 181 YASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
           Y S +A + APRL+LHA++L +  P     +T  AP
Sbjct: 253 YDS-QAES-APRLMLHAQLLDLQLPFSTTRVTVPAP 286


>UniRef50_C9RQF0 Pseudouridine synthase, RluA family n=1 Tax=Fibrobacter
           succinogenes subsp. succinogenes S85 RepID=C9RQF0_FIBSS
          Length = 424

 Score =  106 bits (265), Expect = 5e-22,   Method: Compositional matrix adjust.
 Identities = 77/236 (32%), Positives = 114/236 (48%), Gaps = 29/236 (12%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES--------- 59
           P++  L I+Y+DD I+V+NKP  L+  PG     K ++   +   + +  S         
Sbjct: 73  PEDIPLNIVYEDDDIVVINKPRNLVVHPGN-GVSKGTLAAALLYHFKENLSTVNGPLRPG 131

Query: 60  -VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICD 118
            VHRLD  T G++VVA   AA R L  Q   R   + Y A VWG P   EG +D P+  +
Sbjct: 132 IVHRLDKDTPGLMVVAKNDAAHRHLAHQLETRTLHRTYNALVWGCPRDLEGTIDAPIGRN 191

Query: 119 WPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGD 178
             NR K  V  + GK ++T Y   ++ A  T  + L+  +GR+HQ+RVH    GHP++GD
Sbjct: 192 PKNRLKMAVV-KGGKESRTHYVAKQFFAIATL-LELQLESGRTHQIRVHSRYTGHPVVGD 249

Query: 179 RFY----------------ASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
             Y                 + +   +AP  LL A  + + HP     +TFK P +
Sbjct: 250 PLYDGRDESLNRVPPLMKPVAEKVLEIAPAQLLQAVKIELIHPRTNKKLTFKVPME 305


>UniRef50_C0GNZ6 Pseudouridine synthase, RluA family n=1 Tax=Desulfonatronospira
           thiodismutans ASO3-1 RepID=C0GNZ6_9DELT
          Length = 535

 Score =  106 bits (264), Expect = 6e-22,   Method: Compositional matrix adjust.
 Identities = 76/227 (33%), Positives = 113/227 (49%), Gaps = 22/227 (9%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVM--------TRIQRDYPQAESVHRLDM 65
           L I+Y D  ++V+NKP+GL   P   +     V          R+  D  +   VHRLD 
Sbjct: 83  LDIVYMDREMVVLNKPAGLSVHPSSSDPAPTLVHYLLYACPGLRLMTDRQRPGIVHRLDK 142

Query: 66  ATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQ 125
            T+G++V AL + A+ +L  QF  R   K Y+A V G     EG++++PL  D  +R + 
Sbjct: 143 DTTGLMVAALNQEAKEDLAGQFAGRRVHKTYLALVCGALKQDEGIINVPLARDQQSRARV 202

Query: 126 KVCYETGKPAQTEYEVVEYAADNTARVV-LKPITGRSHQLRVHMLALGHPILGDRFYASP 184
               E G+ A+T Y+V++        +V ++  TGR+HQ+RVH   L HP+LGDR Y   
Sbjct: 203 APSRE-GRSARTAYKVLKRDPSGLWSLVQVQIFTGRTHQIRVHFSHLNHPVLGDRIYGGT 261

Query: 185 E----------ARAMAPRLLLHAEMLTITHPAYGNSMTF--KAPADF 219
           +             +A R LLH+  L I HP     + F  + P DF
Sbjct: 262 DWDRFGWKKRFLSRLAKRQLLHSSCLGIMHPVSRQWLEFISRPPRDF 308


>UniRef50_C8WW59 Pseudouridine synthase n=2 Tax=Alicyclobacillus acidocaldarius
           RepID=C8WW59_ALIAD
          Length = 314

 Score =  106 bits (264), Expect = 6e-22,   Method: Compositional matrix adjust.
 Identities = 76/216 (35%), Positives = 112/216 (51%), Gaps = 14/216 (6%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP--------QAESVHRLDM 65
            V+ Y+DD ++VV+KP G++  PG        V   + R  P        +   VHR+D 
Sbjct: 89  FVVAYEDDDVIVVDKPRGVVVHPGAGHMRGTLVNGLLARGTPLCTLAGALRPGVVHRIDK 148

Query: 66  ATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQ 125
            TSG++V A +  A R L   FR  + +++YVA   G     EG +D+P+  D  +R + 
Sbjct: 149 DTSGLVVFAKSDRAYRALVEAFRAHDVEREYVAIAHGRMPHREGTIDMPIARDPADRQRM 208

Query: 126 KVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPE 185
            V  + GK A T +EV+E  A   + + L+  TGR+HQ+RVH+ A+GHPI GD  Y  P 
Sbjct: 209 AV-RQGGKRAVTHFEVLESFA-KYSYLRLRLETGRTHQIRVHLAAIGHPIAGDPVYG-PR 265

Query: 186 ARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
                    LHA  L  THP  G  + F++  P+D 
Sbjct: 266 HTLPIDGQALHARTLGFTHPD-GRRLRFESAVPSDM 300


>UniRef50_B1ZRU1 Pseudouridine synthase n=2 Tax=Opitutaceae RepID=B1ZRU1_OPITP
          Length = 268

 Score =  106 bits (264), Expect = 7e-22,   Method: Compositional matrix adjust.
 Identities = 80/237 (33%), Positives = 115/237 (48%), Gaps = 37/237 (15%)

Query: 16  ILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQA-ESVHRLDMATSGVIVVA 74
           IL++DD ++  +KPSGLL  P R ++ ++++M  +   +     +VHRLD  TSG+++ A
Sbjct: 6   ILFEDDAMIAFDKPSGLLIAPDRWDKQRENLMGLVHARFGHGVANVHRLDADTSGLLLCA 65

Query: 75  LTKAAERELKRQFREREPKKQYVARVWGHP------------SPAEGL-----VDLPLIC 117
            TK A   L  QF+ +  +K Y++ V   P              A GL     VDL L  
Sbjct: 66  KTKPALDFLSGQFQAKTVQKTYLSLVVVLPPEEAMKVVKPIRDDAGGLPDAFQVDLALGQ 125

Query: 118 DWPNRPKQKVCY-ETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPIL 176
           D     + +V     GK   T++ V+E      A V   P TGR+HQ+RVH+ A G PIL
Sbjct: 126 DERQPGRMRVFKGRGGKDCVTDFRVLERFG-RFALVSCHPQTGRTHQIRVHLAAAGAPIL 184

Query: 177 GDRFYASPEARAMAP-----------------RLLLHAEMLTITHPAYGNSMTFKAP 216
            D FY +PE + +                   RL LHA  LT  HPA    +T +AP
Sbjct: 185 NDPFYGNPEIKLLLSDLKRRYKGRDEEKPLIDRLALHASELTFRHPATRELLTLQAP 241


>UniRef50_C8PQT2 Ribosomal large subunit pseudouridine synthase D n=1 Tax=Treponema
           vincentii ATCC 35580 RepID=C8PQT2_9SPIO
          Length = 246

 Score =  106 bits (264), Expect = 7e-22,   Method: Compositional matrix adjust.
 Identities = 73/226 (32%), Positives = 104/226 (46%), Gaps = 25/226 (11%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAE-------SVHRLDMA 66
             ++Y DD ++ VNK +GLL    R +     +   IQ++ PQ         +VHR+D  
Sbjct: 6   FTLIYADDDMVAVNKAAGLLVAADRWDAEAPRLDLLIQKELPQIAPSCNKLYAVHRIDKD 65

Query: 67  TSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQK 126
           TSG+++ AL   A R L   F+ RE KK Y   + G  S  +  VDLPL  D     +  
Sbjct: 66  TSGILLYALNAEAHRTLNTAFQNREIKKTYRLLIHGRVSEEQFTVDLPLRADGDALHRTV 125

Query: 127 VCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPE- 185
           V    GK A T + V+E      + +   P+TGR+HQ+R H+ A G+PI+ D  Y S + 
Sbjct: 126 VDKRRGKEAVTHFTVLE-TFRQFSLLEACPVTGRTHQIRAHLAAAGYPIVCDSLYGSGKP 184

Query: 186 ----------------ARAMAPRLLLHAEMLTITHPAYGNSMTFKA 215
                            + +  RL LHA  L   HP  G    F A
Sbjct: 185 VLLSELKQRWRGDVYTEQPLIGRLALHAYRLEGVHPRSGQPFAFTA 230


>UniRef50_B2KBB0 Pseudouridine synthase n=1 Tax=Elusimicrobium minutum Pei191
           RepID=B2KBB0_ELUMP
          Length = 299

 Score =  105 bits (263), Expect = 7e-22,   Method: Compositional matrix adjust.
 Identities = 73/224 (32%), Positives = 118/224 (52%), Gaps = 27/224 (12%)

Query: 15  VILYQDDHIMVVNKPSGLLSVPGR--LEEH-------KDSVMTRI--------QRDYPQA 57
           +I+++D ++ V+NKPSG+L  P     EE+       ++++++ I        ++   +A
Sbjct: 76  LIIFEDKNMFVINKPSGMLVHPQSPVWEENPAAAFIGEETLVSLILANPPKNFEKGITRA 135

Query: 58  ESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLIC 117
             VHRLD  TSGV+++A     +  +   F  RE  K Y A V G     +G++++P+  
Sbjct: 136 GLVHRLDKDTSGVMIIAKNSKTQDAMVEMFANREMHKTYEAIVCGVVPDDKGIINVPIGR 195

Query: 118 DWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILG 177
               + K     E G+ A TEY V++   +  + + L P+TGR++QLRVHM  LG+P+LG
Sbjct: 196 VTGGKIK---ASELGREAVTEYSVLQRK-ETVSLMKLHPVTGRTNQLRVHMSWLGYPVLG 251

Query: 178 DRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
           D  Y      A APRL+LH++     HP     + F    P DF
Sbjct: 252 DWLYKG----ATAPRLMLHSKSAEFEHPFTSKPVKFTVAPPKDF 291


>UniRef50_A3VN52 Ribosomal large subunit pseudouridine synthase C n=1
           Tax=Parvularcula bermudensis HTCC2503 RepID=A3VN52_9PROT
          Length = 324

 Score =  105 bits (263), Expect = 8e-22,   Method: Compositional matrix adjust.
 Identities = 63/174 (36%), Positives = 95/174 (54%), Gaps = 3/174 (1%)

Query: 15  VILYQDDHIMVVNKPSGLLSVPG-RLEEHKDSVMTRIQRDYPQAESVHRLDMATSGVIVV 73
           +++Y+DD I+ +NKP+GL    G +   H D ++        +   VHRLD  T GV+++
Sbjct: 96  LVIYEDDDILALNKPAGLAVQGGAKTLIHIDGMLDVFGEGEARPRLVHRLDRDTGGVLLL 155

Query: 74  ALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPL-ICDWPNRPKQKVCYETG 132
           A ++A    L   F++    K Y A   G P P  G +D+ +     P R K +   E G
Sbjct: 156 AKSRAVAATLSLAFQQHRIGKTYWAITKGVPHPLFGRIDMRIEKAGEPGREKMR-GTEQG 214

Query: 133 KPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEA 186
           + A T+Y+ VE A    A + L+P TGR+HQ+RVH+ A+G PI+GDR Y    A
Sbjct: 215 QSALTDYQTVETAGQKAAFLALRPHTGRTHQIRVHLSAIGTPIVGDRKYGGAGA 268


>UniRef50_A4XKV9 Pseudouridine synthase n=1 Tax=Caldicellulosiruptor saccharolyticus
           DSM 8903 RepID=A4XKV9_CALS8
          Length = 292

 Score =  105 bits (263), Expect = 8e-22,   Method: Compositional matrix adjust.
 Identities = 64/185 (34%), Positives = 102/185 (55%), Gaps = 8/185 (4%)

Query: 16  ILYQDDHIMVVNKPSGLLSVPGR---LEEHKDSVMTRIQRDYPQAESVHRLDMATSGVIV 72
           IL++D   + VNKPSG+ S P +    +   ++V   +      +  ++RLD  TSG++V
Sbjct: 79  ILFEDQFFLFVNKPSGIPSHPSKGHYFDTLANNVEWYLNSQGVTSHIINRLDKDTSGIVV 138

Query: 73  VALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYETG 132
            A        +  +F +R  +K Y+A V G  +   G ++ P+     N   ++   E G
Sbjct: 139 FAKNSYFHSIVSSEFEKRTIEKTYIAVVDGILTKKSGFIEKPI--SRSNDGIKREINEDG 196

Query: 133 KPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARAMAPR 192
             A T YEVV+Y  +N + + LKPITGR+HQLRVH+ ++G+PI+GD  Y + + +     
Sbjct: 197 DYAITYYEVVDYK-NNYSILKLKPITGRTHQLRVHLASIGYPIVGDVLYGTGKNKNFP-- 253

Query: 193 LLLHA 197
           LLLHA
Sbjct: 254 LLLHA 258


>UniRef50_O50310 Uncharacterized RNA pseudouridine synthase Cpar_0723 n=13
           Tax=Chlorobiaceae RepID=Y723_CHLP8
          Length = 327

 Score =  105 bits (263), Expect = 8e-22,   Method: Compositional matrix adjust.
 Identities = 79/240 (32%), Positives = 115/240 (47%), Gaps = 37/240 (15%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVP------GRLEEHKDSVMTRIQRDYPQAES--- 59
           P++  + ILY+DD +MV++K +G++  P      G L    ++++  + +D  + +    
Sbjct: 72  PEDIPITILYEDDDLMVIDKEAGMVVHPAFGNWTGTL---ANAILHHLGKDADELDKTEM 128

Query: 60  ----VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPL 115
               VHRLD  TSG+I++A    A  +L RQF  R+ +K Y A VWG P    G +   +
Sbjct: 129 RPGIVHRLDKDTSGLIIIAKNPTALHKLARQFANRQVEKVYKAIVWGVPKAESGTIKTNI 188

Query: 116 ICDWPNRP-KQKVCYE--TGKPAQTEYEVVE-YAADNTARVVLKPITGRSHQLRVHMLAL 171
                NR       YE   GK A T+Y+VVE     +   V L   TGR+HQ+RVH+  L
Sbjct: 189 GRSHKNRKVMANFPYEGAEGKHAITDYQVVEDLGYFSLMDVTLH--TGRTHQIRVHLQHL 246

Query: 172 GHPILGDRFYASPEARA---------------MAPRLLLHAEMLTITHPAYGNSMTFKAP 216
           GH ILGD  Y     R                +  R  LHA+ L    P  G  ++F AP
Sbjct: 247 GHSILGDETYGGATPRTLPFSKSEPFTRNLLELMSRQALHAQTLRFRQPTTGEPLSFSAP 306


>UniRef50_C1A885 Pseudouridine synthase n=1 Tax=Gemmatimonas aurantiaca T-27
           RepID=C1A885_GEMAT
          Length = 329

 Score =  105 bits (263), Expect = 9e-22,   Method: Compositional matrix adjust.
 Identities = 69/216 (31%), Positives = 113/216 (52%), Gaps = 16/216 (7%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES--------VHRLDM 65
           L ++Y+D+H++VV+K +G++  P         V   + R  P AE         VHRLD 
Sbjct: 83  LDVVYEDEHLLVVDKAAGMVVHPAPGNWTGTLVNALLGRGEPLAEGGGEDRAGLVHRLDK 142

Query: 66  ATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQ 125
            TSG++VVA + AA R L      R+  ++Y A  WGH +     V+ P+  D  +R + 
Sbjct: 143 DTSGLLVVAKSDAAHRTLSSALAARQVTRRYAAVCWGHLAEERITVEKPIARDPRDRTRM 202

Query: 126 KVCYETGKPAQTEY-EVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASP 184
            +  ++GK ++T++  +  + + +  R  L   TGR+HQ+RVH+ + GHP++GD  Y   
Sbjct: 203 AIV-QSGKASRTDFTRLARFDSVDLLRAHLH--TGRTHQIRVHLASTGHPVVGDDTYGGG 259

Query: 185 EARAMA----PRLLLHAEMLTITHPAYGNSMTFKAP 216
             R +A     R  LHA  L   HP  G+ +  ++P
Sbjct: 260 GGRRLALLPPRRHFLHAAWLRFRHPISGDLIDLRSP 295


>UniRef50_A6G930 Pseudouridine synthase n=1 Tax=Plesiocystis pacifica SIR-1
           RepID=A6G930_9DELT
          Length = 356

 Score =  105 bits (263), Expect = 9e-22,   Method: Compositional matrix adjust.
 Identities = 81/241 (33%), Positives = 122/241 (50%), Gaps = 34/241 (14%)

Query: 9   PQEPWLV----ILYQDDHIMVVNKPSGLLSVP-GRLEEHKDSVMTRIQRDYPQA--ESVH 61
           P+EP ++    ++++D  ++V++KP  L   P  R   H  + + R +R  P+   E  H
Sbjct: 98  PEEPAVILDYGVVHEDPDVLVLDKPGNLPVHPTARYHRHTLTALMR-RRLGPKHGWEMAH 156

Query: 62  RLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEG--LVDLPLICDW 119
           R+D  TSGVI+    KA+  ++K  F  RE  K+Y+A V G     EG  L+D+PL    
Sbjct: 157 RIDRETSGVIIFGRRKASGPKIKGSFFRREVHKEYLAIVLGRLELPEGPRLIDMPLGSAV 216

Query: 120 PNRPKQKV----CYETGKPAQTEYEVVEYAADNTARVVLK---PITGRSHQLRVHMLALG 172
            ++   K+      E G PAQT  EV+ +       + L    P TGR+HQ+RVH+  +G
Sbjct: 217 GSKIMIKMGPRPVDEGGLPAQTTIEVLAHGEHRGQPITLVRCLPRTGRTHQIRVHLAEIG 276

Query: 173 HPILGDRFYASP-----------------EARAMAPRLLLHAEMLTITHPAYGNSMTFKA 215
           HPILGD+ YA+                  EAR    R  LHA  L++ HP  G+ + + A
Sbjct: 277 HPILGDKLYAAEEDEFLAVVEDGEPVAELEARLGLWRQALHARALSLPHPTTGDGVRYVA 336

Query: 216 P 216
           P
Sbjct: 337 P 337


>UniRef50_A1K5H7 Pseudouridine synthase n=5 Tax=Proteobacteria RepID=A1K5H7_AZOSB
          Length = 260

 Score =  105 bits (263), Expect = 9e-22,   Method: Compositional matrix adjust.
 Identities = 75/213 (35%), Positives = 107/213 (50%), Gaps = 24/213 (11%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDY--PQAESVHRLDMATSGVI 71
           L ILYQD+H++ ++KPSGLL     L+ H++    ++ RD        VHRLD  TSGV+
Sbjct: 2   LEILYQDEHLVAIHKPSGLLVHRSALDAHEERFAVQLLRDQLGRHVHPVHRLDKGTSGVL 61

Query: 72  VVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYE- 130
           V AL +     L  QF  R  +KQYVA V GHP+ A G +D PL   +   P + V  + 
Sbjct: 62  VFALDRDTAGRLATQFETRAVRKQYVAIVRGHPAEA-GTIDHPLSRRFD--PVEHVAEDK 118

Query: 131 --TGKPAQTEYE----------VVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGD 178
               +PA T +           V  Y     A + L+P TGR HQ+R H+  + HPI+GD
Sbjct: 119 VFAPQPAITRFRRLATAELPWAVDRYPTSRYALLALEPETGRRHQIRRHLKHISHPIIGD 178

Query: 179 RFYASPEARAM------APRLLLHAEMLTITHP 205
             +   +   M      + R+LL    + + HP
Sbjct: 179 STFGKGKHNRMFQAHFGSERMLLACTDIELRHP 211


>UniRef50_B1I3F8 Pseudouridine synthase n=2 Tax=Bacteria RepID=B1I3F8_DESAP
          Length = 309

 Score =  105 bits (263), Expect = 9e-22,   Method: Compositional matrix adjust.
 Identities = 73/216 (33%), Positives = 104/216 (48%), Gaps = 9/216 (4%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVP--GRLEEHKDSVMTRIQRDYPQAES------V 60
           P+   L + ++D  ++VVNKP GL+  P  G       + +    RD            V
Sbjct: 76  PEAIPLEVCFEDPDVLVVNKPRGLVVHPAVGHYSGTLVNALLHHCRDLSGINGILRPGIV 135

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLD  TSG+++VA   AA   L  Q ++R   ++Y A V G P    G VD P+     
Sbjct: 136 HRLDRDTSGLLMVAKNDAAHLALAGQLKDRAVLRRYTALVHGRPRRETGTVDAPIGRHPR 195

Query: 121 NRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRF 180
           +R +  V   +G+ A+T Y VV    D  + + L   TGR+HQ+RVHM  +GHP++GD  
Sbjct: 196 DRQRMAVTPRSGRAARTHYRVVRR-FDKFSLLELTLDTGRTHQIRVHMAHVGHPLVGDLK 254

Query: 181 YASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
           Y             LHA  L   HP  G  + F+AP
Sbjct: 255 YGHARPELGLEGQFLHAGTLGFRHPRTGEVLVFEAP 290


>UniRef50_C0MA80 Pseudouridine synthase n=6 Tax=Streptococcus RepID=C0MA80_STRE4
          Length = 300

 Score =  105 bits (263), Expect = 9e-22,   Method: Compositional matrix adjust.
 Identities = 69/202 (34%), Positives = 104/202 (51%), Gaps = 16/202 (7%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTR---IQRDYP--QAESVHRLDMATS 68
           L I+Y+D+H +++NKP+G  S+P  +  +  +   +   I++DYP  Q   V RLD  TS
Sbjct: 76  LDIVYEDEHFLILNKPAGYASIPSAIHSNTIANFIKAYYIKQDYPNKQVHIVTRLDRDTS 135

Query: 69  GVIVVALTKAAERELKRQFREREPKKQYVARVWGHPS-PAEGLVDLPLICDWPNRPKQKV 127
           G+++ A    A   L +Q ++R   K+Y A V G    P +G +  P+      R    +
Sbjct: 136 GLMLFAKHGYAHARLDKQLQQRAINKRYYALVCGQERLPDQGEIIAPI-----GRTDDSI 190

Query: 128 CYET----GKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYAS 183
              T    GK A+T Y+V+    +N + V +   TGR+HQ+RVH   LG P+LGD  Y  
Sbjct: 191 ITRTVTPKGKYAKTSYKVIARYPENVSLVDITLHTGRTHQIRVHFAHLGFPLLGDDLYGG 250

Query: 184 PEARAMAPRLLLHAEMLTITHP 205
                M  R  LH   L+ THP
Sbjct: 251 RLDLGMT-RQALHCHHLSFTHP 271


>UniRef50_B1H073 Ribosomal large subunit pseudouridine synthase C n=1 Tax=uncultured
           Termite group 1 bacterium phylotype Rs-D17
           RepID=B1H073_UNCTG
          Length = 238

 Score =  105 bits (262), Expect = 9e-22,   Method: Compositional matrix adjust.
 Identities = 72/220 (32%), Positives = 110/220 (50%), Gaps = 26/220 (11%)

Query: 16  ILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAE--SVHRLDMATSGVIVV 73
           I+YQD++I+VVNKPSG+  +PGR   +++  +  I R+  + +   VH +D   SGV+V 
Sbjct: 7   IIYQDENILVVNKPSGMFVIPGR-NIYENKTLVEILRNQLKQKLWVVHIIDRDASGVLVF 65

Query: 74  ALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYETGK 133
           A      R +  QF   + +K+Y+A + G     EG ++ PLI    N         TGK
Sbjct: 66  AKNPETHRNISVQFENSKIRKKYIALLSGVLEENEGTINKPLIISGKNVR----IDITGK 121

Query: 134 PAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGD--------------- 178
            + T+++V+E     T    L P+T + HQ+R+H  +LGHP+  D               
Sbjct: 122 ESITDFKVLENFRSYTLVNAL-PLTVKRHQIRIHFWSLGHPLAIDGEYGTLDPIFLSSFK 180

Query: 179 RFYASPEARAMAP---RLLLHAEMLTITHPAYGNSMTFKA 215
           R Y   + +   P   RL LHA  LT+  P  G   TF+A
Sbjct: 181 RGYKIKKGKTENPLISRLTLHAAALTLILPGSGEEKTFEA 220


>UniRef50_A4FXG9 Pseudouridine synthase, RluA family n=5 Tax=Methanococcus
           RepID=A4FXG9_METM5
          Length = 298

 Score =  105 bits (262), Expect = 1e-21,   Method: Compositional matrix adjust.
 Identities = 60/225 (26%), Positives = 120/225 (53%), Gaps = 21/225 (9%)

Query: 2   GMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGR----------LEEHKDSVMTRIQ 51
           G+ N +P ++  L ++Y+DD +++V+KP  ++  P +          +  H+     +I 
Sbjct: 71  GINNIDP-EKLLLCVIYEDDDLLIVDKPKNMVVHPTKNVLSGTLANAISNHQ-----KIN 124

Query: 52  RDYPQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLV 111
               +   V+RLDM T+G++++A    + ++L +Q  E   +K Y+  V GH    EG++
Sbjct: 125 NQNYKIRFVNRLDMDTTGLLIIAKNSYSHQQLAKQMDEGILEKIYIVVVNGHLDSKEGVI 184

Query: 112 DLPLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLAL 171
           +  +  D  +   ++     GK ++T+Y+V+E   +N + + +K +TGR+HQ+RVH+ + 
Sbjct: 185 EDSI--DLNDDGIKRELSTFGKISKTKYKVIE-EFNNVSVLEIKLLTGRTHQIRVHLSSF 241

Query: 172 GHPILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
           G+ I+GD  Y   +   +  R  LH+ +L   HP    +M  ++ 
Sbjct: 242 GNNIIGDTLYG--KTADLIERQALHSHILRFIHPITKENMEIRSK 284


>UniRef50_B9DS29 Pseudouridine synthase n=85 Tax=Firmicutes RepID=B9DS29_STRU0
          Length = 301

 Score =  105 bits (262), Expect = 1e-21,   Method: Compositional matrix adjust.
 Identities = 76/219 (34%), Positives = 109/219 (49%), Gaps = 20/219 (9%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRI-----QRDYP--QAESVHRLDMA 66
           L I+Y+DDH +V+NKP G  S+P  +  H +++   I     +++YP  Q   V RLD  
Sbjct: 76  LDIVYEDDHFLVLNKPVGYASIPSAI--HSNTIANFIKAYYFEQNYPNKQVHIVTRLDRD 133

Query: 67  TSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQK 126
           TSG+++ A    A   L +Q ++R  +K+Y A V G+      L D   I +   R K  
Sbjct: 134 TSGLMLFAKHGYAHARLDKQLQKRSIEKRYFALVSGNGQ----LPDFGEIVEPIGRSKDS 189

Query: 127 VCYET----GKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYA 182
           +   T    GK A+T YEVV   A+N   V +K  TGR+HQ+RVH   +G P+LGD  Y 
Sbjct: 190 IITRTVDPMGKYAKTTYEVVARFAENVHLVDIKLHTGRTHQIRVHFSHIGFPLLGDDLYG 249

Query: 183 SPEARAMAPRLLLHAEMLTITHPAYGNSM--TFKAPADF 219
                 +  R  LH   L+  +P   N    T     DF
Sbjct: 250 GRMDLGI-ERQALHCHFLSFFNPFTENESIHTINLTEDF 287


>UniRef50_B9JWI8 Pseudouridine synthase n=1 Tax=Agrobacterium vitis S4
           RepID=B9JWI8_AGRVS
          Length = 330

 Score =  105 bits (262), Expect = 1e-21,   Method: Compositional matrix adjust.
 Identities = 76/215 (35%), Positives = 115/215 (53%), Gaps = 16/215 (7%)

Query: 15  VILYQDDHIMVVNKPSGLLSVPGR-LEEHKDSVM---TRIQRDYPQAESVHRLDMATSGV 70
           ++L++D+ + V+NKP+GL    G  L  H D ++   T  + + P+   VHRLD  TSGV
Sbjct: 96  MLLHEDEKVFVLNKPAGLAVQGGSGLNRHIDQMLEAWTSKKGEKPRL--VHRLDRDTSGV 153

Query: 71  IVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYE 130
           +VVA T+ A ++L   FRER+ KK Y A V G P   +  +   ++ +      +     
Sbjct: 154 LVVARTRGAAQKLTAAFRERDTKKTYWALVKGVPRKHDDKISTWVVKEQTEDGDRMRIAR 213

Query: 131 TGKP----AQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEA 186
            G+     A + Y V+E AA + A + ++P TGR+HQLR+H L +GHPI+GD  Y   + 
Sbjct: 214 HGEDGADHAVSYYRVLETAAQSLAWLEMEPYTGRTHQLRLHALHIGHPIIGDPKYYIDDP 273

Query: 187 R-----AMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
                  +  RL LHA  + I HP  G  +   AP
Sbjct: 274 NWDFPGGVQKRLHLHARHIDIPHPD-GGRLRITAP 307


>UniRef50_B7P2L1 Ribosomal pseudouridine synthase, putative n=1 Tax=Ixodes
           scapularis RepID=B7P2L1_IXOSC
          Length = 263

 Score =  105 bits (262), Expect = 1e-21,   Method: Compositional matrix adjust.
 Identities = 79/239 (33%), Positives = 120/239 (50%), Gaps = 27/239 (11%)

Query: 3   MENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQA----- 57
           ME+ +   E  + +L+   H +VV+KP+ ++    R +EH  +V T ++R +P+      
Sbjct: 1   MEDNHGISERSICVLHLSPHFVVVDKPADVVINTQRPDEHPVTVETLLKRLHPELVDTGV 60

Query: 58  ----ESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDL 113
                  HRLD +TSGV+ +AL K + R  +R F +R  KK YVA + GH      LVD 
Sbjct: 61  HHSFRFCHRLDFSTSGVLCLALHKQSARSAQRAFHQRLAKKYYVAILEGHVRDDHVLVDS 120

Query: 114 PLICDWPNRPKQKVCYE------TGKPAQTEYEVV---EYAADNTARVVLKPITGRSHQL 164
           P+  D   +   K+C        + + AQT   V+           +V+L+P+TGR HQL
Sbjct: 121 PIGEDKRPQHSHKMCTADKDYCVSPRGAQTRLLVLWRGLLKGRPATKVLLRPVTGRRHQL 180

Query: 165 RVHMLALGHPILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAP----ADF 219
           RVH  +LGH I+GD  Y      A + R+ LHA  L +  P    ++  + P    ADF
Sbjct: 181 RVHCASLGHTIVGDFTYGED---ASSRRMFLHACRLVL--PTEVETLDVETPDPFAADF 234


>UniRef50_D1CBT6 Pseudouridine synthase n=1 Tax=Thermobaculum terrenum ATCC BAA-798
           RepID=D1CBT6_THET1
          Length = 313

 Score =  105 bits (262), Expect = 1e-21,   Method: Compositional matrix adjust.
 Identities = 71/200 (35%), Positives = 100/200 (50%), Gaps = 12/200 (6%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES--------VHRLDM 65
           L ++Y+DD I+V++KP+G++  P         V   I R YP            VHRLD 
Sbjct: 91  LRVVYEDDKIIVIDKPAGMVVHPSPGHYDNTLVNALIAR-YPDLLKQPTDRPGIVHRLDK 149

Query: 66  ATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQ 125
            TSG+I+VA        L+ Q + R+  K+Y     G   P EG ++ P+  D  +R K 
Sbjct: 150 DTSGLIIVARDLDTLNYLQGQMKARKIFKEYTLLCCGALDPPEGRIEAPIGRDLRDRTKM 209

Query: 126 KVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPE 185
            V    GK A TEY  ++     T   + +PITGR+HQ+RVH  A+GHPI GD  Y +  
Sbjct: 210 SVI-AGGKEAVTEYSTIQSLGKYTL-AIARPITGRTHQIRVHFAAIGHPIAGDPIYGNCR 267

Query: 186 ARAMAPRLLLHAEMLTITHP 205
              +  R  LHA  L +  P
Sbjct: 268 LEGLN-RQFLHASRLGVVMP 286


>UniRef50_B8CWB7 Pseudouridine synthase n=1 Tax=Halothermothrix orenii H 168
           RepID=B8CWB7_HALOH
          Length = 310

 Score =  105 bits (262), Expect = 1e-21,   Method: Compositional matrix adjust.
 Identities = 69/218 (31%), Positives = 114/218 (52%), Gaps = 8/218 (3%)

Query: 4   ENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSV-----MTRIQRDYPQAE 58
           + Y  P    L I+Y+D H++V+NKP+ +L  P  +E+    V       R Q +Y    
Sbjct: 83  KTYYDPAPLDLDIIYEDRHLLVINKPANMLVHPTPVEKSNTIVNGVLYHMRNQGNYNLVR 142

Query: 59  SVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICD 118
            +HRLD  T+G++++A  + A   +  QF+     ++Y+A V G+    +  ++ P+   
Sbjct: 143 PIHRLDRNTTGLLLIAKNQYAHNYITHQFQNNNIHREYLAFVHGNVEFKKESINAPIGKT 202

Query: 119 WPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGD 178
             +  K+KV +  GK A T  +VV+      + + +K  TGR+HQ+RVH+  LGHP+LGD
Sbjct: 203 RDSLIKRKVDHTLGKRAVTHIKVVK-PGGLISLIRVKLETGRTHQIRVHLSHLGHPLLGD 261

Query: 179 RFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
             Y   +   +  R  LH+  +T   P     +TFKAP
Sbjct: 262 TLYGGED--ILIKRPALHSYKVTCCLPFKHKEVTFKAP 297


>UniRef50_C1FEQ4 Predicted protein n=2 Tax=Micromonas RepID=C1FEQ4_9CHLO
          Length = 357

 Score =  105 bits (262), Expect = 1e-21,   Method: Compositional matrix adjust.
 Identities = 79/250 (31%), Positives = 119/250 (47%), Gaps = 39/250 (15%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLL----------SVPGRLEEHKDSVMTRIQR-----D 53
           P+   L ++++DDH++VVNKP G++          S+   L  H +    R        D
Sbjct: 98  PENIPLDVVFEDDHLVVVNKPPGMVVHPSAGHAGGSLVNALLFHCNERSNRGDDASKMID 157

Query: 54  YPQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDL 113
            P+   VHR+D  TSG++V+A   AA+  L+ QF  R  +++Y+A V G P+   G +D 
Sbjct: 158 VPRLGVVHRIDKGTSGLLVMAKDAAAQAGLQTQFANRSVRRRYLAIVLGTPARESGRIDA 217

Query: 114 PLICDWPNRPKQKVCY-ETGKPAQTEYEV-VEYAADNTARVVLKPITGRSHQLRVHMLAL 171
           P+  D  +R K  +    TG+ A + + V       N + V  +  TGR+HQ+RVH   +
Sbjct: 218 PIGRDPADRLKMAIVRGATGRQAISNFGVRARLVRGNASLVEWQLETGRTHQIRVHAREM 277

Query: 172 GHPILGDRFY--------------------ASPEARAMAPRLLLHAEMLTITHPAYGNSM 211
           GHPI+GD  Y                    A+ E  A   R +LHA  L   HP  G  +
Sbjct: 278 GHPIVGDEAYGGGGSAAAEFLRRDGAMSAAAAREIVAKCARPMLHARSLGFRHPVTGEEI 337

Query: 212 TFKA--PADF 219
           +F    P DF
Sbjct: 338 SFAVEPPPDF 347


>UniRef50_D2R760 Pseudouridine synthase, RluA family n=2 Tax=Planctomycetaceae
           RepID=D2R760_9PLAN
          Length = 603

 Score =  105 bits (261), Expect = 1e-21,   Method: Compositional matrix adjust.
 Identities = 72/212 (33%), Positives = 111/212 (52%), Gaps = 12/212 (5%)

Query: 16  ILYQDDHIMVVNKPSGL-LSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDMATSGVIVVA 74
           ++Y+D+ I VV+KP+ L L   GR   +    + R   D  +   VHRLD  TSG+++ A
Sbjct: 381 VVYEDEAIAVVHKPAPLPLHASGRFHRNTLEWILREIYDPQKPRPVHRLDANTSGLVLFA 440

Query: 75  LTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYETGKP 134
            T+   + L++QF + + +K Y+A V GHP     +   P+  +      + V  E G P
Sbjct: 441 RTRHFAKLLQQQFTQGKVEKFYLALVSGHPVEDRFVSTAPISAEAGVFGSRSVDEEAGLP 500

Query: 135 AQTEYEVV--EYAADN--TARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARAMA 190
           A+T +EV+     AD    A V  +PITGR++Q+RVH+  LGHPI+G++ Y + +     
Sbjct: 501 AETRFEVLARTTTADGKPVALVRCQPITGRTNQIRVHLWQLGHPIMGEQSYLADQKHGTT 560

Query: 191 -------PRLLLHAEMLTITHPAYGNSMTFKA 215
                  P L L A  L+  HP     MTF +
Sbjct: 561 QTHTVDDPPLCLLAHQLSFQHPVSRERMTFTS 592


>UniRef50_Q4FN11 Pseudouridine synthase n=4 Tax=Bacteria RepID=Q4FN11_PELUB
          Length = 326

 Score =  105 bits (261), Expect = 1e-21,   Method: Compositional matrix adjust.
 Identities = 72/234 (30%), Positives = 106/234 (45%), Gaps = 29/234 (12%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGR-----------LEEHKDSVMTRIQRDYPQA 57
           P    L I+Y+DD ++++NKP+G++  PG            +  +KDS+ T      P  
Sbjct: 77  PYNFKLQIVYEDDDLLIINKPAGIIMHPGAGNYDETIVNALMHYNKDSLSTIGDELRPGI 136

Query: 58  ESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLIC 117
             VHR+D  TSG+IV+A        L  QF E    + Y   +WG   P+ G +D  +  
Sbjct: 137 --VHRIDKDTSGLIVIAKNNETHENLSHQFSEHTITRVYQLLIWGKLRPSSGKIDTFITR 194

Query: 118 DWPNRPKQKVCYETGKPAQTEYEVVE-YAADNTARVVL---KPITGRSHQLRVHMLALGH 173
              NR   +V    GK A T Y+ +E +  D T  + L   +  TGR+HQ+RVHM  +G+
Sbjct: 195 SSKNRQMMEVSNSKGKRAITNYKTIEIFENDKTPTLSLVECRLETGRTHQIRVHMTHMGN 254

Query: 174 PILGDRFYASPEARAMA------------PRLLLHAEMLTITHPAYGNSMTFKA 215
            I+GD  Y     +                R  LHA+ L   HP     M F +
Sbjct: 255 SIMGDGKYKKKYKKLKNIDTNLENLIYKLDRQFLHAQTLGFIHPRTNEEMVFTS 308


>UniRef50_C1E6N6 Pseudouridine synthase n=2 Tax=Micromonas RepID=C1E6N6_9CHLO
          Length = 363

 Score =  105 bits (261), Expect = 1e-21,   Method: Compositional matrix adjust.
 Identities = 78/226 (34%), Positives = 116/226 (51%), Gaps = 29/226 (12%)

Query: 16  ILYQDDHIMVVNKPSGLL-----SVPGRLEEHKD-----SVMTRIQRDYPQAESV---HR 62
           ++++D    VVNKP  +        PG++          SV   ++R YP  ++V   H+
Sbjct: 132 LVHEDADYAVVNKPWCVRLDTPRGWPGKVRFTPKYPGDLSVEDWLERRYPDWDTVRFCHQ 191

Query: 63  LDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNR 122
           LD ATSGV+V A  K A     + FRER  +K Y+A V+GHP   E  VD+P+  D P+ 
Sbjct: 192 LDNATSGVLVAASNKRAAGAAAKLFRERRARKTYLAIVFGHPEQDEWTVDVPMGRD-PDD 250

Query: 123 PK---QKVCYETGKPAQTEYEVVEYAADN---------TARVVLKPITGRSHQLRVHMLA 170
           PK   ++V  E GK  +T + V++    N          ++V + P+TGR HQ+R+H+  
Sbjct: 251 PKGFRERVDPEHGKACETRFRVLKRGRLNLRGKFEGVPVSKVEVTPVTGRRHQIRLHLQF 310

Query: 171 LGHPILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
            GHPI+GD  Y+       + R  LHA  LT+       +M F AP
Sbjct: 311 SGHPIVGDNAYSQD---TDSFRTFLHAHKLTLPFDEPRGTMQFVAP 353


>UniRef50_C6XFD0 Pseudouridine synthase n=1 Tax=Candidatus Liberibacter asiaticus
           str. psy62 RepID=C6XFD0_LIBAP
          Length = 340

 Score =  105 bits (261), Expect = 1e-21,   Method: Compositional matrix adjust.
 Identities = 80/237 (33%), Positives = 114/237 (48%), Gaps = 35/237 (14%)

Query: 14  LVILYQDDHIMVVNKPSGLLS--VPGR--------LEEHKDSVMTRIQRDYPQAESVHRL 63
           L ILY+DD I+V+NKP+GL+    PG         L  H  + ++ I     +   VHRL
Sbjct: 90  LDILYEDDDIIVINKPAGLVVHPAPGNWTGTLVNALLYHCHNNLSSIN-GVKRPGIVHRL 148

Query: 64  DMATSGVIVVALTKAAERELKRQF----REREPKKQYVARVWGHPSPAEGLVDLPLICDW 119
           D  T+GV+VVA    A ++L  QF    +    K+ Y A VWG P P  G+++ PL    
Sbjct: 149 DKDTTGVMVVAKNDLAHQKLSEQFVDHGKSTRLKRAYYAMVWGIPLPDSGIINAPLGRCK 208

Query: 120 PNRPKQKVCY---ETGKPAQTEYEVVE-YAADNTARVVLKPI---TGRSHQLRVHMLALG 172
            NR ++ V     +T   A T Y+ +E Y  ++   V L      TGR+HQ+RVHM   G
Sbjct: 209 SNRLRRAVKGIDDKTADSAITHYQTIEIYNKNSNFAVSLLKCHLETGRTHQIRVHMAHKG 268

Query: 173 HPILGDRFYA-------------SPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
           +P++GD  Y              +  A     R  LHA  L+ +HP     M F+ P
Sbjct: 269 NPLIGDPLYGKGFKTKANIVNNNAKSAILSLARQALHAHSLSFSHPRNNQDMDFQVP 325


>UniRef50_C8W9Q3 Pseudouridine synthase n=2 Tax=Atopobium RepID=C8W9Q3_ATOPD
          Length = 246

 Score =  105 bits (261), Expect = 1e-21,   Method: Compositional matrix adjust.
 Identities = 62/222 (27%), Positives = 116/222 (52%), Gaps = 21/222 (9%)

Query: 14  LVILYQDDHIMVVNKPSGLL---------SVPGRLEEHKDSVMTRIQRDYPQAESVHRLD 64
           L  LYQDD+++ VNKP+G++         S+   + E   ++ +  + D  Q ++++RLD
Sbjct: 10  LEFLYQDDYLLAVNKPAGMIVHSDGTNEPSLTDLVCEKLCALESSNKIDLSQVQALNRLD 69

Query: 65  MATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPK 124
             T+G+++ +L K  + +  +    +E  K+Y+A V G     + L+D  +  D  +  K
Sbjct: 70  KETTGIVLFSLKKETQPQFDQLIASKELSKEYLAVVKGDFGLNKLLIDKAIGKDRHDAQK 129

Query: 125 QKVCYETGKPAQTEYEVVEYAADNTARV----VLKPITGRSHQLRVHMLALGHPILGDRF 180
            ++  +TGKP+QTE  +++ A+    ++    ++  +TGR HQ+RVH+ +LG P++GD  
Sbjct: 130 MRIS-DTGKPSQTEVRLIKVASSAQGQIQSLLLVNLLTGRKHQIRVHLSSLGFPLVGDVL 188

Query: 181 YASPEARAMAPR-------LLLHAEMLTITHPAYGNSMTFKA 215
           Y    +     +       L+LHA  +   HP  G  +  K 
Sbjct: 189 YGGMSSLQRKTKKKHRPQPLMLHAYRIGFIHPVTGAKIVIKT 230


>UniRef50_C9LM35 Pseudouridine synthase n=1 Tax=Dialister invisus DSM 15470
           RepID=C9LM35_9FIRM
          Length = 308

 Score =  105 bits (261), Expect = 1e-21,   Method: Compositional matrix adjust.
 Identities = 70/213 (32%), Positives = 107/213 (50%), Gaps = 10/213 (4%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESV---------HRLD 64
           L ILY+D+ ++V+NK  G++  PG        V   +     Q  SV         HRLD
Sbjct: 80  LDILYEDNDMIVINKRRGVVVHPGAGNTEGTLVNALLFHCGEQLRSVGDPERPGIVHRLD 139

Query: 65  MATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPK 124
             TSGV+V A ++ A   L+++    + ++ Y+A V G      G++ LPL     +R K
Sbjct: 140 KDTSGVMVAAKSERAYGILQKEIASHKAQRCYIALVHGQMEGDTGVIRLPLGRSTKDRMK 199

Query: 125 QKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASP 184
             V +ETG+PA T + V+EY   + + +  K  TGR+HQ+RVHM  + H ++ D  Y   
Sbjct: 200 WDVLHETGRPAVTHFHVIEYLP-HYSWIECKLETGRTHQIRVHMAHIRHAVVNDPLYGWK 258

Query: 185 EARAMAPRLLLHAEMLTITHPAYGNSMTFKAPA 217
           +         LH+  L + HP  G  M F+AP 
Sbjct: 259 KDHFPIKGQALHSHTLELCHPITGEVMHFEAPV 291


>UniRef50_Q1J0S8 Pseudouridine synthase n=7 Tax=Deinococci RepID=Q1J0S8_DEIGD
          Length = 341

 Score =  105 bits (261), Expect = 1e-21,   Method: Compositional matrix adjust.
 Identities = 79/227 (34%), Positives = 110/227 (48%), Gaps = 23/227 (10%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR----DYPQAES----- 59
           P+   L +LY+D+H++ VNKP G+++ P         V   + R    + P A       
Sbjct: 92  PEAVPLDVLYEDEHLIAVNKPPGMVTHPAPGVTSGTLVNALLGRLTLPEQPGAVGPDGYR 151

Query: 60  ---VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVA---RVWGHPSPAEGLVDL 113
              VHRLD  TSGVIVVA T  A   L   F++R   K Y+A    +W    P    V+ 
Sbjct: 152 PGIVHRLDKDTSGVIVVAKTVEAHARLAAAFKDRSTHKTYLAIAAGMWKAQGPVS--VNA 209

Query: 114 PLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVL----KPITGRSHQLRVHML 169
           P+      R +  V     + AQT +  +    D   R +     +P TGR+HQ+RVH+ 
Sbjct: 210 PVGRHPTARQRMTVGGVGPREAQTLFTPLATHPDGHGRTLALVRAQPHTGRTHQIRVHLA 269

Query: 170 ALGHPILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
            LG PILGD  Y    A A+ PR  LHA+ LT+ HP  G ++   AP
Sbjct: 270 HLGSPILGDAVYG--RASAVMPRHALHAQFLTLPHPVTGETLHLHAP 314


>UniRef50_C6VVP1 Pseudouridine synthase n=4 Tax=Bacteroidetes RepID=C6VVP1_DYAFD
          Length = 228

 Score =  105 bits (261), Expect = 2e-21,   Method: Compositional matrix adjust.
 Identities = 72/215 (33%), Positives = 105/215 (48%), Gaps = 17/215 (7%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRD------YPQAESVHRLDMAT 67
           L ILY+ D ++ +NKP+GLL     +    D    ++ RD      YP     HRLD  T
Sbjct: 4   LEILYRSDDLVAINKPNGLLVHRSPIASDADVFAVQLLRDQLSQKVYP----AHRLDRKT 59

Query: 68  SGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKV 127
           SGV++ AL +    E++ +F E E  K Y A V GH +   G +D PL  D         
Sbjct: 60  SGVLLFALNENVNSEMQGKFMEGEITKTYHAIVRGHTAD-RGEIDYPLKRDDGVTQDAVT 118

Query: 128 CYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEAR 187
            +ET   A+  + + ++A    + V L P+TGR HQLR HM  + HPI+GDR +   +  
Sbjct: 119 HFETLARAEVPFALGKHATSRYSLVQLNPLTGRMHQLRKHMAHIMHPIIGDRPHGCNKQN 178

Query: 188 AMAP------RLLLHAEMLTITHPAYGNSMTFKAP 216
                     +++LHA  +   HP  G  +T  AP
Sbjct: 179 RFFKEELGMIQMMLHAVSVEFVHPVSGQHVTIVAP 213


>UniRef50_B2A2J2 Pseudouridine synthase n=1 Tax=Natranaerobius thermophilus
           JW/NM-WN-LF RepID=B2A2J2_NATTJ
          Length = 328

 Score =  104 bits (260), Expect = 2e-21,   Method: Compositional matrix adjust.
 Identities = 73/224 (32%), Positives = 113/224 (50%), Gaps = 18/224 (8%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRI---------QRDYPQAES 59
           PQ   L I+Y+D++++VVNKP  ++  PG    ++D+++  +            Y +   
Sbjct: 86  PQSIPLDIVYEDEYLLVVNKPRNMVVHPG-AGNYRDTMVNALLYHCQNLSDGTSYERPGI 144

Query: 60  VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDW 119
           VHRLD  TSG++VVA        L  + + R   + Y+A V G  S  +  +DLP+  D 
Sbjct: 145 VHRLDKDTSGLLVVAKQNETHDILSEEIKNRRVARTYLALVIGDFSKKKATIDLPIGRDP 204

Query: 120 PNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPI--TGRSHQLRVHMLALGHPILG 177
            NR K  V +  GK A T+ E++    +      LK    TGR+HQ+RVH+  LG+P+LG
Sbjct: 205 RNRKKMAVVH-GGKRAITKVEMLRSFQNPEKISYLKCSLETGRTHQIRVHLSHLGYPLLG 263

Query: 178 DRFYASPEARAM-----APRLLLHAEMLTITHPAYGNSMTFKAP 216
           D  Y     + +          LH+  L  THP +  +M F+AP
Sbjct: 264 DPVYRGKTGKNVDIDKNLTGQALHSFSLAFTHPVFKKTMVFRAP 307


>UniRef50_D0MJ49 Pseudouridine synthase n=2 Tax=Bacteria RepID=D0MJ49_RHOM4
          Length = 355

 Score =  104 bits (260), Expect = 2e-21,   Method: Compositional matrix adjust.
 Identities = 84/254 (33%), Positives = 112/254 (44%), Gaps = 52/254 (20%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVM-------------------------- 47
           L I+Y+D +++VVNK +GL+  P R       V                           
Sbjct: 86  LDIVYEDPYLIVVNKQAGLVVHPARGNRSGTLVNALLYYIGSGPVRFDEEDDLPEDDEIG 145

Query: 48  --------TRIQRDYPQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVAR 99
                   T  + + P+   VHRLD  T+G+IVVA        L RQF  R   + Y+A 
Sbjct: 146 LSMVSTGPTEAKLEAPRPGIVHRLDKDTTGLIVVAKDDVTHTGLARQFEHRTIARTYLAI 205

Query: 100 VWGHPSPAEGLVDLPLICDWPNRPKQKVC-YETGKPAQTEYEVVEYAADNTARVVLKPIT 158
           VWG P P  G ++  +  D  +R +  V   + GK A T YEVVE A    A V  K  T
Sbjct: 206 VWGVPDPPRGRIEAAIGRDPRDRQRMAVVPDDRGKRAVTHYEVVE-ALPAAALVRFKLET 264

Query: 159 GRSHQLRVHMLALGHPILGDRFYA---------SPEARAMAPRLL-------LHAEMLTI 202
           GR+HQ+RVH   +GHP+LGD  Y          +P  RA   +L        LHA  L  
Sbjct: 265 GRTHQIRVHARHIGHPVLGDPTYGGRTIRYGPHTPRRRAFYDQLFARLTRQALHAHTLGF 324

Query: 203 THPAYGNSMTFKAP 216
            HP  G  + F+AP
Sbjct: 325 RHPRTGEWLEFEAP 338


>UniRef50_C6VN18 Pseudouridine synthase n=3 Tax=Lactobacillus plantarum
           RepID=C6VN18_LACPJ
          Length = 293

 Score =  104 bits (260), Expect = 2e-21,   Method: Compositional matrix adjust.
 Identities = 76/216 (35%), Positives = 113/216 (52%), Gaps = 19/216 (8%)

Query: 16  ILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES-------VHRLDMATS 68
           I Y+D + +V+NKP+GL SVPG      D+++ RI+     + +       + RLD  TS
Sbjct: 79  IEYEDANWLVLNKPAGLTSVPGP-SNRTDTLVNRIKGYLIASHASNQRPHLITRLDRDTS 137

Query: 69  GVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPL--ICDWPNRPKQK 126
           G+++VA  + A+  L       +  K Y A + G  +PA G +D P+  + D P R    
Sbjct: 138 GLVLVAKHRVAQGMLTEPRIAAQLVKTYQAWIEGTITPASGTIDRPIGRVADSPRR---- 193

Query: 127 VCYETGKPAQTEYEV-VEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPE 185
           V    G+ A T Y+V  +    N +R+ L+ +TGR+HQ+RVH+ ALGHP+LGD  Y    
Sbjct: 194 VVTTAGQRAITTYQVEADQLQHNVSRLRLELVTGRTHQIRVHLTALGHPLLGDTLYGG-- 251

Query: 186 ARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
             A   R  LHA  L    P    ++ F+A  PAD 
Sbjct: 252 NLAWIQRQALHAASLQFFDPFSEQTLHFEAALPADL 287


>UniRef50_P0A5T2 Uncharacterized RNA pseudouridine synthase Rv1540/MT1592 n=131
           Tax=Actinobacteria (class) RepID=Y1540_MYCTU
          Length = 308

 Score =  104 bits (260), Expect = 2e-21,   Method: Compositional matrix adjust.
 Identities = 78/217 (35%), Positives = 112/217 (51%), Gaps = 19/217 (8%)

Query: 14  LVILYQDDHIMVVNKPSGLL----------SVPGRLEEHKDSVMTRIQRDYPQAESVHRL 63
           + ILY DD I+ V+KP+ +           +V G L      + T     + +   VHRL
Sbjct: 81  MTILYSDDDIVAVDKPAAVAAHASVGWTGPTVLGGLAAAGYRITT--SGVHERQGIVHRL 138

Query: 64  DMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRP 123
           D+ TSGV+VVA+++ A   LKR F+ R   K+Y A V GHP P+ G +D P+     +  
Sbjct: 139 DVGTSGVMVVAISERAYTVLKRAFKYRTVDKRYHALVQGHPDPSSGTIDAPIGRHRGHEW 198

Query: 124 KQKVCYETGKPAQTEYEVVE-YAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFY- 181
           K  +  + G+ + T Y+ +E + A +   V L+  TGR+HQ+RVH  AL HP  GD  Y 
Sbjct: 199 KFAIT-KNGRHSLTHYDTLEAFVAASLLDVHLE--TGRTHQIRVHFAALHHPCCGDLVYG 255

Query: 182 ASPE--ARAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
           A P+   R    R  LHA  L   HPA G  +   +P
Sbjct: 256 ADPKLAKRLGLDRQWLHARSLAFAHPADGRRVEIVSP 292


>UniRef50_A8IAL9 Pseudouridine synthase n=2 Tax=Xanthobacteraceae RepID=A8IAL9_AZOC5
          Length = 384

 Score =  104 bits (259), Expect = 2e-21,   Method: Compositional matrix adjust.
 Identities = 71/211 (33%), Positives = 111/211 (52%), Gaps = 10/211 (4%)

Query: 15  VILYQDDHIMVVNKPSGLLSVPGRLE-EHKDSVMTRIQ-RDYPQAESVHRLDMATSGVIV 72
           +IL++D  ++V+NKPSG+    G     H D ++  ++ +D  +   VHR+D  T+G ++
Sbjct: 147 IILFEDKDVLVLNKPSGIAVQGGSGTFRHIDGMLDALRAKDGQKPRLVHRIDKDTAGCLL 206

Query: 73  VALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCY--- 129
           +A  + +  +L + FR RE +K Y A V G P P +G +   L  +     + +V     
Sbjct: 207 IAKNRLSAAQLAKNFRSREARKIYWALVPGVPKPRQGRISTYLARE-EAEERMRVARHGE 265

Query: 130 ETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEA--- 186
           E    A T Y VVE+AA   + + LKP+TGR+HQ+R H+  + HPI+GD  Y + E    
Sbjct: 266 EDASHAVTYYAVVEHAAQKMSWLSLKPVTGRTHQIRAHLAHIHHPIVGDPKYFNIENWEL 325

Query: 187 -RAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
              +  RL L A  L I HP     +   AP
Sbjct: 326 PGGLQNRLHLLARRLVIPHPRGEGMIDVSAP 356


>UniRef50_A3I3R5 Ribosomal large subunit pseudouridine synthase n=2 Tax=Bacillaceae
           RepID=A3I3R5_9BACI
          Length = 279

 Score =  104 bits (259), Expect = 2e-21,   Method: Compositional matrix adjust.
 Identities = 70/215 (32%), Positives = 110/215 (51%), Gaps = 10/215 (4%)

Query: 5   NYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHK---DSVMTRIQRDYPQ-AESV 60
           +Y P     + I+Y+DDH ++V+KP G+ + P    +     + V+  IQ+     AE V
Sbjct: 67  SYKPTPVCAIDIVYEDDHCLIVSKPKGMATHPNDDRDTHTCMNHVIAHIQQQGGMYAEHV 126

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLD  T G+++VA    A+    R   E+   + Y A V G+   + G +   +  D  
Sbjct: 127 HRLDKGTQGLLLVAKHPLAKSIFDRMIEEKSIIRTYAAEVQGNIRSSSGTISESIGKD-R 185

Query: 121 NRPKQKVCYETGKPAQTEYEVVE-YAADNTARVVLKPITGRSHQLRVHMLALGHPILGDR 179
           +   ++V  +TG+ A T YEVV  Y       ++L+  TGR+HQ+RVH+  +GHPI+GD 
Sbjct: 186 HHASRRVVSKTGQHAVTHYEVVSRYKNSCVVHLILE--TGRTHQIRVHLAYIGHPIIGDT 243

Query: 180 FYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFK 214
            Y + E   ++    LHA  L   HP     +T K
Sbjct: 244 MYGARE--TVSDDYELHAIQLEFDHPFLNKRITVK 276


>UniRef50_C9KIU1 Pseudouridine synthase n=3 Tax=Veillonellaceae RepID=C9KIU1_9FIRM
          Length = 296

 Score =  104 bits (259), Expect = 2e-21,   Method: Compositional matrix adjust.
 Identities = 75/216 (34%), Positives = 117/216 (54%), Gaps = 14/216 (6%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHK---DSVMT--RIQRDYPQAESVHRL 63
           P++  L I Y+DD++++VNKP+G L  P   E H    ++V+   +   ++     VHRL
Sbjct: 73  PEDLPLDIRYEDDYLLIVNKPAGQLVHPTTKEAHGTLGNAVLYWYKAHGEHHAYHPVHRL 132

Query: 64  DMATSGVIVVALTKAAERELKRQFREREPK---KQYVARVWGHPSPAEGLVDLPLICDWP 120
           D  TSG++++A  K  + + K   R  E K   ++Y+A + G  +P EGL+D P+    P
Sbjct: 133 DRNTSGLVLIA--KVPQVQYKLTPRHGEGKLFHREYLALIEGELTPPEGLIDAPIARALP 190

Query: 121 NRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRF 180
           +   +KV  + G+ A+T Y+ V+      + + L   TGR+HQ+RVH+  LGHP+LGD  
Sbjct: 191 SIILRKVSPD-GQTARTHYDTVQTDG-KLSLIHLVLDTGRTHQIRVHLAHLGHPLLGDDL 248

Query: 181 YASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
           Y    AR    R  LHA  L   HP  G  +  + P
Sbjct: 249 YGGNLAR--IKRQALHAARLHFRHPMTGAEIDVQVP 282


>UniRef50_Q2SS88 Pseudouridine synthase n=4 Tax=Mollicutes RepID=Q2SS88_MYCCT
          Length = 322

 Score =  104 bits (259), Expect = 2e-21,   Method: Compositional matrix adjust.
 Identities = 66/221 (29%), Positives = 104/221 (47%), Gaps = 11/221 (4%)

Query: 5   NYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES----- 59
           N    ++  L I+YQDD ++V+NK + +   P  L    ++++  +     +  S     
Sbjct: 86  NITKNKDIDLNIIYQDDDLLVINKQNNITVHPS-LNNTNNTIVNALLASDVELSSINGEL 144

Query: 60  ----VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPL 115
               VHR+D  T+G+++VA      + L   F+  +  K+Y+A V G   P +GL+D P+
Sbjct: 145 RPGIVHRIDKQTTGLLIVAKNDKTHKLLSEMFKNHQIYKEYLAIVTGVIKPNKGLIDAPI 204

Query: 116 ICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPI 175
                +R K  V  +  K A T +EVVE    NT  +  +  TGR+HQ+RVH   + HP+
Sbjct: 205 GRSQTDRKKMSVTAKNSKHAITTFEVVERFLKNTL-IKCQIQTGRTHQIRVHFNYINHPV 263

Query: 176 LGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
           L D  Y             LHA  L  THP     +   +P
Sbjct: 264 LNDPIYGKKHQEFTDFGQYLHAYKLKFTHPITKKEIELISP 304


>UniRef50_C8P137 Pseudouridine synthase n=1 Tax=Erysipelothrix rhusiopathiae ATCC
           19414 RepID=C8P137_ERYRH
          Length = 291

 Score =  104 bits (259), Expect = 2e-21,   Method: Compositional matrix adjust.
 Identities = 79/224 (35%), Positives = 122/224 (54%), Gaps = 25/224 (11%)

Query: 5   NYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES----- 59
           ++N  ++  L ILY+D  I+VV+KP  LL+V  R EE   +   R+  DY + +      
Sbjct: 62  SHNQQRDTPLQILYEDKDILVVDKPYKLLTVSNRKEEELTAF--RLASDYVKKQDSKNRI 119

Query: 60  --VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLV--DLPL 115
             VHRLD  TSGV++ A ++  +R  + ++ E   ++ YVA V       EG+V  D  +
Sbjct: 120 FVVHRLDQDTSGVLMFAKSEYVKRLYQDKWSELVDERLYVAIV-------EGVVPKDKDV 172

Query: 116 ICDWPNRPKQKVCYET--GKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGH 173
           I  +  + K    Y T  G+ A T YEV++   +NT  + ++  TGR +Q+RVHM  +GH
Sbjct: 173 IRSFLRQNKTTHMYSTSSGQEAITNYEVIKRTENNTI-LKIQIDTGRKNQIRVHMNDIGH 231

Query: 174 PILGDRFYASPEARAM-APRLLLHAEMLTITHPAYGNSMTFKAP 216
           PI+GD+ Y   +A+     RL LHA  L + +P     MTF +P
Sbjct: 232 PIIGDKKY---DAKTNPLKRLGLHAYRLRVMNPKTKKMMTFVSP 272


>UniRef50_D0LU78 Pseudouridine synthase n=1 Tax=Haliangium ochraceum DSM 14365
           RepID=D0LU78_HALO1
          Length = 369

 Score =  104 bits (259), Expect = 2e-21,   Method: Compositional matrix adjust.
 Identities = 78/241 (32%), Positives = 115/241 (47%), Gaps = 33/241 (13%)

Query: 7   NPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQA--ESVHRLD 64
            PP    + +LY D H++V++KP+GL  V      + +++   +   +P    +  HRLD
Sbjct: 101 EPPCPRTIGVLYSDPHMLVIDKPAGL-PVHASARFYFNTLTRVLGERFPGQPMQICHRLD 159

Query: 65  MATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEG----------LVDLP 114
             TSG +VVA  K     LK  F ++   K Y+A VWG P   +G          ++DLP
Sbjct: 160 RETSGALVVARGKPEAARLKGAFADKRAHKTYLALVWGDPPWPDGAWDSAPEDDAIIDLP 219

Query: 115 L--ICDWPNRPKQKVCYETGK-PAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLAL 171
           L  + D   R K ++    G  P+ T   V+E      A V   P+TGR HQ+R H+ A 
Sbjct: 220 LGLVADESARIKIRMEVRAGALPSLTRVRVLERRG-RAALVRCLPLTGRQHQIRAHLAAC 278

Query: 172 GHPILGDRFYASPE-------ARAMAPRLL---------LHAEMLTITHPAYGNSMTFKA 215
           GHPI+GD+ YA  +        R M P LL         LHA  + + HP  G  +  ++
Sbjct: 279 GHPIVGDKLYAHGDDVFAAYCDRGMTPELLERVRLPRQALHAAAIALPHPFEGRQVRAES 338

Query: 216 P 216
           P
Sbjct: 339 P 339


>UniRef50_B9XHZ1 Pseudouridine synthase, RluA family n=2 Tax=Verrucomicrobiales
           RepID=B9XHZ1_9BACT
          Length = 599

 Score =  104 bits (259), Expect = 3e-21,   Method: Compositional matrix adjust.
 Identities = 68/210 (32%), Positives = 109/210 (51%), Gaps = 10/210 (4%)

Query: 16  ILYQDDHIMVVNKPSGL-LSVPGRLEEHKDSVMTRIQRDYPQA-ESVHRLDMATSGVIVV 73
           IL++D+ ++V+NKP+ L +   GR   +    +   Q  +PQ   + HRLD  TSGV++V
Sbjct: 381 ILHEDEALIVLNKPAPLPMHAGGRFNRNTLEYILH-QVYHPQKPRAAHRLDANTSGVVLV 439

Query: 74  ALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYETGK 133
             T+     L+ QF   E  K Y+ +V G P       + P+  +      ++V +E G 
Sbjct: 440 TRTRHFASHLQPQFAHGEVGKFYLVKVQGTPKEDSFSCNAPISAEPSEAGAREVDFEEGL 499

Query: 134 PAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFY-------ASPEA 186
           P++TE+ V++  AD T  +  +P+TGR++Q+RVH+  +G P+ GD  Y        +   
Sbjct: 500 PSRTEFRVLQRNADGTTLLEARPLTGRTNQIRVHLWQMGLPVCGDPVYLPGNKLGETQTL 559

Query: 187 RAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
           R     L LHA  +T  HP +   M F AP
Sbjct: 560 RVEDAPLCLHAWRVTFLHPLHRQRMEFTAP 589


>UniRef50_C1CWT3 Pseudouridine synthase n=1 Tax=Deinococcus deserti VCD115
           RepID=C1CWT3_DEIDV
          Length = 321

 Score =  104 bits (259), Expect = 3e-21,   Method: Compositional matrix adjust.
 Identities = 79/223 (35%), Positives = 111/223 (49%), Gaps = 23/223 (10%)

Query: 14  LVILYQDDHIMVVNKPSGLLS--VPGRLEEH-KDSVMTRI----QRDYPQAES-----VH 61
           L ++Y+DD+++ VNKP G+++   PG L     ++++ R+    Q DY          VH
Sbjct: 77  LDVIYEDDYLIAVNKPPGMVTHPAPGVLSGTLVNALLGRMPLPEQPDYDSEAGYRPGIVH 136

Query: 62  RLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARV---WGHPSPAEGLVDLPLICD 118
           RLD  TSGVIVVA T  A   L   F++RE +K Y+A     W    PA   V+ P+   
Sbjct: 137 RLDKDTSGVIVVAKTVGAHARLAAAFKDRETRKTYLAIAAGQWRADGPAR--VEAPIGRH 194

Query: 119 WPNRPKQKVCYETGKPAQTEYEVVEYAADNTAR----VVLKPITGRSHQLRVHMLALGHP 174
              R +  V     + AQT +  +    D   R    V  +P TGR+HQ+RVH+  LG P
Sbjct: 195 PVQRQRMTVGGANPREAQTLFTPLAAHPDGHGRTLALVRAQPRTGRTHQIRVHLAHLGSP 254

Query: 175 ILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPA 217
           ILGD  Y       +  R  LHA  L++ HP  G  +   APA
Sbjct: 255 ILGDAVYGRSSETML--RHALHAHFLSVPHPGTGRLLHLHAPA 295


>UniRef50_C0QPR5 Pseudouridine synthase n=4 Tax=Hydrogenothermaceae
           RepID=C0QPR5_PERMH
          Length = 319

 Score =  104 bits (259), Expect = 3e-21,   Method: Compositional matrix adjust.
 Identities = 70/215 (32%), Positives = 112/215 (52%), Gaps = 19/215 (8%)

Query: 16  ILYQDDHIMVVNKPSGLLS--VPGRLEEHKDSVMTRIQRDYPQ------AESVHRLDMAT 67
           IL++D+ I VV KP+G++    PG       + +    R+  +      A  VHRLD  T
Sbjct: 87  ILFEDEDIAVVYKPAGMVVHPSPGHTSGTLVNALLYHFRNISEYGGKERAGIVHRLDKDT 146

Query: 68  SGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKV 127
           +G++++A ++ A +EL++QF+ER   K+Y+A V G      G +DLP+     NR K   
Sbjct: 147 AGLMIIAKSEFAHKELQKQFQERTVDKRYIAVVTGIVQNDHGFIDLPIGRSIYNRKKMGT 206

Query: 128 CYETGKPAQTEYEVVEYA-ADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYA---- 182
                + A TEY V   +  +N   V +K  TGR+HQ+RVH  A+GHP+  D+ Y     
Sbjct: 207 EATNLRDALTEYWVKNRSEKENLTVVDIKLHTGRTHQIRVHFSAIGHPLFNDKVYGFKKS 266

Query: 183 ---SPEARAMAPRLLLHAEM---LTITHPAYGNSM 211
              S + R+++ + L HA +   +   HP  G  +
Sbjct: 267 QLRSEKMRSISDQTLYHALLAYRIAFDHPRTGEKI 301


>UniRef50_Q0F3G2 Possible pseudouridine synthase n=1 Tax=Mariprofundus ferrooxydans
           PV-1 RepID=Q0F3G2_9PROT
          Length = 325

 Score =  103 bits (258), Expect = 3e-21,   Method: Compositional matrix adjust.
 Identities = 75/228 (32%), Positives = 117/228 (51%), Gaps = 22/228 (9%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQ--RDYPQAESV------ 60
           P++  L IL++D+H++V+NKP+G++  P    +H   V   +   +  P    V      
Sbjct: 83  PEDLPLDILFEDEHLIVLNKPAGIVVHPSHGHDHGTLVHALLHHCKTLPGINGVERPGIV 142

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLD  TSG +V+A ++   + L   F E    +QY+A   G PS     ++LP I   P
Sbjct: 143 HRLDKDTSGSLVIAKSEVVHQRLSEMFAEHNLNRQYIAWCRGVPSWRVKCIELP-IGRHP 201

Query: 121 NRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRF 180
           ++ ++    ++G+ + T+   VE+     +++ L   TGR+HQ+RVHM     P+LGD  
Sbjct: 202 HQRQKMAVTDSGRESITD-AAVEHIFGPFSQMRLTLHTGRTHQIRVHMAHENLPVLGDPV 260

Query: 181 YAS--------PE----ARAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
           YA         PE    A A   R  LHAE+L   HP  G  M+F+AP
Sbjct: 261 YARSYHPGREIPEPARHAIATLSRQALHAELLEFDHPISGEPMSFRAP 308


>UniRef50_B9XS18 Pseudouridine synthase n=1 Tax=bacterium Ellin514
           RepID=B9XS18_9BACT
          Length = 536

 Score =  103 bits (258), Expect = 3e-21,   Method: Compositional matrix adjust.
 Identities = 74/217 (34%), Positives = 110/217 (50%), Gaps = 18/217 (8%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLS-VPGRLEEHKDSVMTRIQRDYPQAES---VHRLDM 65
           +E   +IL++D+H++VVNKP+G+ +  P       + +   ++   P+  S   VHRLD 
Sbjct: 6   EEAGRLILFEDEHLLVVNKPAGMNTHAPSPYA--GEGIYEWLKHREPRWASLAIVHRLDK 63

Query: 66  ATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLIC---DWPNR 122
            TSGV+V   T  A R L  QF     +K+Y+       S     +   L+     + +R
Sbjct: 64  ETSGVMVFGKTTVANRSLTEQFTNHSIRKKYLLLTDKVVSSQTSTMVSCLVRVGEKYLSR 123

Query: 123 PKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYA 182
           P     +  G+ A+T +EV+  A   T  V  +PITGR+HQ+RVH    G PILGD  Y 
Sbjct: 124 P----VHAGGEKAETHFEVITKAEGGTL-VEAEPITGRTHQIRVHAAEQGFPILGDALYG 178

Query: 183 SPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
             +    A R+ LHA  L + HP     MTF+A  +F
Sbjct: 179 GTK----ASRVCLHAAELKLKHPGTNAEMTFRAEPNF 211


>UniRef50_Q1AVY4 Pseudouridine synthase n=2 Tax=Rubrobacteridae RepID=Q1AVY4_RUBXD
          Length = 305

 Score =  103 bits (258), Expect = 3e-21,   Method: Compositional matrix adjust.
 Identities = 81/209 (38%), Positives = 111/209 (53%), Gaps = 16/209 (7%)

Query: 16  ILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES------VHRLDMATSG 69
           IL++D+HI VV+KP+G++  PG        V   + R     E       VHRLD  TSG
Sbjct: 78  ILFEDEHIAVVDKPAGMVVHPGAGNRSGTLVNALLGRGIAGGEDPERPGIVHRLDRDTSG 137

Query: 70  VIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCY 129
           ++VVA  + A   L      R  ++ Y A V G   P  G VD P+  D P  P   +  
Sbjct: 138 LMVVAKGEPAYSRLVEMLAARRVRRVYRALVVGEGLPPSGTVDSPVGRD-PENPAL-MAA 195

Query: 130 ETGKPAQTEYEVVEYAADNTA-RVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARA 188
             G+PA T +EV+  AA +T  RV L+  TGR+HQ+RVH+ A+G+P+  D  Y     RA
Sbjct: 196 GVGRPAVTHFEVLGEAAGHTMLRVRLE--TGRTHQIRVHLSAIGYPVYADPLY----GRA 249

Query: 189 M-APRLLLHAEMLTITHPAYGNSMTFKAP 216
           +   RL LHAE L+  HPA G  + F +P
Sbjct: 250 VPGRRLWLHAERLSFEHPAEGRPLDFFSP 278


>UniRef50_C8X1I9 Pseudouridine synthase, RluA family n=1 Tax=Desulfohalobium
           retbaense DSM 5692 RepID=C8X1I9_DESRD
          Length = 547

 Score =  103 bits (258), Expect = 3e-21,   Method: Compositional matrix adjust.
 Identities = 76/213 (35%), Positives = 111/213 (52%), Gaps = 21/213 (9%)

Query: 16  ILYQDDHIMVVNKPSGLLSVPGR------LEEHKDSVMTRIQR-DYPQAESVHRLDMATS 68
           ++Y D  ++VVNK +G+   PG       L  H  ++   + R D  +   VHRLD  TS
Sbjct: 93  VVYSDPDVVVVNKAAGVTVHPGTGCESGTLVHHLAALYPELARFDGERPGVVHRLDKDTS 152

Query: 69  GVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVC 128
           G++ VAL ++A   L R F  RE  K+Y+  V G P  AEG VD PL  D  ++ +  V 
Sbjct: 153 GLLTVALNESARLALTRSFARREVDKEYLTLVHGRPE-AEGTVDHPLGRDPQSKIRMAVV 211

Query: 129 YETGKPAQTEYEVVEYAADNTARVV-LKPITGRSHQLRVHMLALGHPILGDRFYASPEAR 187
              GK A T ++ V  + D    ++ ++ +TGR+HQ+RVHM  LG P++GD  Y  P+A+
Sbjct: 212 PRGGKEALTRFKRVWTSPDGRVSLLRVRILTGRTHQIRVHMAYLGFPLVGDALYG-PQAQ 270

Query: 188 A-----------MAPRLLLHAEMLTITHPAYGN 209
           A           +A   +LHA  L   HP  G 
Sbjct: 271 AAFQRSRPLLARLAKHHMLHAWRLAFPHPRSGR 303


>UniRef50_Q1WS68 Pseudouridine synthase n=2 Tax=Lactobacillus salivarius
           RepID=Q1WS68_LACS1
          Length = 304

 Score =  103 bits (258), Expect = 3e-21,   Method: Compositional matrix adjust.
 Identities = 72/207 (34%), Positives = 106/207 (51%), Gaps = 15/207 (7%)

Query: 16  ILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES-----VHRLDMATSGV 70
           I++++D ++VVNKP G+ S P   + ++   +      Y  A       VHRLDM TSG 
Sbjct: 88  IIFENDDLLVVNKPQGIKSHPN--QPYETGTLVNYIAGYLDARDEHPYMVHRLDMLTSGA 145

Query: 71  IVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYE 130
           ++VA        L R       K+ Y+A   G     EG++DLP+  D  ++ K+KV   
Sbjct: 146 MIVAKNPVVVPILTRLISTHTIKRDYLAITEGIFDQKEGVIDLPIGKDENDKRKRKVDGI 205

Query: 131 TGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFY--ASPEARA 188
              PA+T Y+V++   +N+  V L+  TGR+HQLRVH+ A+GHPI+GD  Y   S E   
Sbjct: 206 GALPARTRYQVIKEFENNSV-VYLRLETGRTHQLRVHLSAMGHPIVGDVLYNHVSEEKHM 264

Query: 189 MAPRLLLHAEMLTITHPAYGNSMTFKA 215
           M     LH     +T P     +  KA
Sbjct: 265 M-----LHGYKQKLTLPFSMRELELKA 286


>UniRef50_A4CVN5 Pseudouridine synthase n=1 Tax=Synechococcus sp. WH 7805
           RepID=A4CVN5_SYNPV
          Length = 215

 Score =  103 bits (258), Expect = 3e-21,   Method: Compositional matrix adjust.
 Identities = 72/180 (40%), Positives = 95/180 (52%), Gaps = 9/180 (5%)

Query: 21  DH--IMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDMATSGVIVVALTKA 78
           DH  +MVV+KP+GLL  PG     +DS+++R+Q   P    VHRLD  TSG++++A    
Sbjct: 16  DHPRLMVVDKPAGLLCQPGLGSHQQDSLISRLQLACPALRLVHRLDRDTSGLVLLAKDPD 75

Query: 79  AERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYETGKPAQTE 138
             R L   F  R  +K YVA V G      GL+ LPL      +P     +  GK   T 
Sbjct: 76  MLRLLGMFFASRRVRKLYVADVQGQMKNVSGLIGLPL-ARLKRQPPTYGVHPGGKACVTL 134

Query: 139 YEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEA-----RAMAPRL 193
           +  ++    +T R+ L P TGRSHQLR H+ AL HPI+GD  Y    A     RAMA R 
Sbjct: 135 WRRLKLMESST-RLWLCPRTGRSHQLRAHLAALHHPIIGDPIYNPGCAVGLRLRAMALRF 193


>UniRef50_UPI000178A5E6 pseudouridine synthase, RluA family n=1 Tax=Geobacillus sp.
           Y412MC10 RepID=UPI000178A5E6
          Length = 302

 Score =  103 bits (258), Expect = 3e-21,   Method: Compositional matrix adjust.
 Identities = 72/210 (34%), Positives = 109/210 (51%), Gaps = 14/210 (6%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVH-------RLDMA 66
           L +LY+DD  +VVNKP+GL   P    E +++ +  +   Y +AE +H       RLD  
Sbjct: 82  LQVLYEDDFCLVVNKPAGLAVHPD--NESRETTLNHVVAAYYEAEGIHAAVRHIHRLDKD 139

Query: 67  TSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQK 126
           T+G ++ A  + A+ +L    RE++  + Y A V G  S     +DLP+  D  +  +++
Sbjct: 140 TTGPVLYAKNEYAQLKLDEAMREKKIVRMYAAIVQGRVSQELKRIDLPIGKDRYHASRRR 199

Query: 127 VCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEA 186
           V   TG+ A T     E A    + + ++  TGR+HQ+RVH+  +GHP+LGD  Y  P  
Sbjct: 200 VSL-TGQAAITHILSAE-AYPKASLLHIRLETGRTHQIRVHLSHMGHPLLGDVLYGGPGT 257

Query: 187 RAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
            A   R  LH E L   HP  G S+   AP
Sbjct: 258 FA---RQALHGERLLFHHPFTGESIEVPAP 284


>UniRef50_A7NB61 Pseudouridine synthase n=18 Tax=Francisella RepID=A7NB61_FRATF
          Length = 332

 Score =  103 bits (257), Expect = 4e-21,   Method: Compositional matrix adjust.
 Identities = 72/219 (32%), Positives = 110/219 (50%), Gaps = 26/219 (11%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGR-----------LEEHKDSVMTRIQRDYPQAESVHR 62
           L I+++DD I+V++KP  ++  PG            L  +KD      Q   P+A  VHR
Sbjct: 88  LKIIFEDDDIIVIDKPVNMIVHPGAGNPTGTVSNALLHRYKD------QDKLPRAGIVHR 141

Query: 63  LDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNR 122
           LD  TSG++V A +  A   L +Q  ER+  ++Y+A V G     +G ++ P+  D  NR
Sbjct: 142 LDKDTSGLMVAAKSSIAYHNLVQQLAERKVSRKYLAIVEGEIY-QQGTINQPIGRDPTNR 200

Query: 123 PKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYA 182
            K  + Y  GK A T Y  +E   D    +  +  TGR+HQ+RVHM ++ HP++GD+ Y 
Sbjct: 201 TKMAINYR-GKEAITYYTPIE-VYDGFTLIECQLETGRTHQIRVHMKSIKHPLVGDQTYN 258

Query: 183 SPEAR------AMAPRLLLHAEMLTITHPAYGNSMTFKA 215
               +       +  R  LHA  L+  HP     + FK+
Sbjct: 259 KSSTKLEKLAITIPTRQALHAYKLSFIHPTTAKMVKFKS 297


>UniRef50_Q1VZ16 Pseudouridine synthase n=1 Tax=Psychroflexus torquis ATCC 700755
           RepID=Q1VZ16_9FLAO
          Length = 292

 Score =  103 bits (257), Expect = 4e-21,   Method: Compositional matrix adjust.
 Identities = 71/213 (33%), Positives = 113/213 (53%), Gaps = 32/213 (15%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVM----TRIQRD---YPQAESVHRLDMA 66
           L ++++DD + VVNKP G  +     +  ++++     T  ++D   YPQ   VHRLD  
Sbjct: 87  LKVIFEDDSMAVVNKPEGYPTNGNYFKTIENALTYNLKTSSEKDKLPYPQP--VHRLDNP 144

Query: 67  TSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDL-PLICDWPNRPKQ 125
           TSG++++A T +++  L   F   +  K Y+A V GH    EGL D+  L  D       
Sbjct: 145 TSGLLIIAKTLSSKSYLSVLFEHNKVHKIYLAIVEGH---FEGLSDIISLDID------- 194

Query: 126 KVCYETGKPAQTEYEV---VEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYA 182
                 GK + T Y V    +   D  + + LKP +GR+HQLR+H+  +GHPI+GD+ Y 
Sbjct: 195 ------GKQSSTNYGVEKMFKINQDEFSLLSLKPSSGRTHQLRIHLSKIGHPIVGDKTYG 248

Query: 183 SPEARAMAPRLLLHAEMLTITHPAYGNSMTFKA 215
           S     ++ +L+LHA  L + HP    S++F+ 
Sbjct: 249 S---LTLSNKLMLHASSLELRHPKTDKSLSFET 278


>UniRef50_B8I750 Pseudouridine synthase, RluA family n=2 Tax=Clostridium
           RepID=B8I750_CLOCE
          Length = 299

 Score =  103 bits (257), Expect = 4e-21,   Method: Compositional matrix adjust.
 Identities = 72/221 (32%), Positives = 111/221 (50%), Gaps = 14/221 (6%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESV-------H 61
           PQ+  L ++Y+D+ ++V+NK SG++  P     H D+ +      Y + + V        
Sbjct: 74  PQDIPLDVIYEDECMLVLNKQSGIVVHPTSY--HPDNTIANGIVYYLKQKGVTKKVRPVS 131

Query: 62  RLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPN 121
           RLD  TSG+I+ A  +  +  L +Q      KK+Y+  V G P   EG ++LP I   P 
Sbjct: 132 RLDRETSGIIIFAKNQFTQEMLIQQMHNNLFKKEYLGIVQGIPQNNEGTINLP-IARKPG 190

Query: 122 RPKQKVCYETGKPAQTEYEVVE-YAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRF 180
               +   E G P+ T Y++++ + + N+A +  K  TGR+HQ+RVH  A+G PI GD  
Sbjct: 191 SIMLRHISEEGAPSITHYKILKTFPSHNSALLSFKLETGRTHQIRVHCKAMGFPIYGDTL 250

Query: 181 YASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
           Y S        R  LH+    I HP     + FKA  P+D 
Sbjct: 251 Y-SDNTNLFISRQALHSYRTEIIHPVTLKGVIFKAELPSDI 290


>UniRef50_Q6MEC0 Pseudouridine synthase n=1 Tax=Candidatus Protochlamydia
           amoebophila UWE25 RepID=Q6MEC0_PARUW
          Length = 318

 Score =  103 bits (257), Expect = 4e-21,   Method: Compositional matrix adjust.
 Identities = 76/218 (34%), Positives = 113/218 (51%), Gaps = 14/218 (6%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLS--VPGRLE-EHKDSVMTRIQR-----DYPQAESV 60
           P+   L ILY+D+H++V+NKP+G++    PG       ++++   Q+     D  +   V
Sbjct: 82  PENIPLSILYEDEHLLVINKPAGMVVHPAPGNWSGTFVNALLYYCQKLPLLPDTIRPGIV 141

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLD  TSG++V A T   +++L   F  R+  K Y+A   G P  A+G +  P I   P
Sbjct: 142 HRLDKGTSGLLVAAKTLETQQKLIELFASRKVYKAYLAICIGRP--ADGEIQAP-IGRHP 198

Query: 121 NRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRF 180
              KQ     TGKPA +  + + ++ D  + V ++  TGR+HQ+RVHM   G PILGD  
Sbjct: 199 IHRKQMAVIPTGKPAISFCKTLGWS-DKLSFVQIEIATGRTHQIRVHMKYRGSPILGDPL 257

Query: 181 YA--SPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
           Y   S       P  LLHA +L   HP    ++ F  P
Sbjct: 258 YGQISLNQYYSVPHQLLHAAVLRFQHPISLENLEFCTP 295


>UniRef50_C7LZI3 Pseudouridine synthase n=1 Tax=Acidimicrobium ferrooxidans DSM
           10331 RepID=C7LZI3_ACIFD
          Length = 309

 Score =  103 bits (257), Expect = 5e-21,   Method: Compositional matrix adjust.
 Identities = 71/201 (35%), Positives = 105/201 (52%), Gaps = 15/201 (7%)

Query: 15  VILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES----------VHRLD 64
           V+ Y+DD + V++KP+GL+     L + + SV       +P   +          VHRLD
Sbjct: 79  VVCYEDDDVAVIDKPAGLIVHRTHLRDVRPSVADWALERWPSLRALPGDPLRRGLVHRLD 138

Query: 65  MATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPK 124
             TSG++V+AL+  A   L+R   + E +++Y A V G P P    ++ PL  D  +  +
Sbjct: 139 RGTSGLMVIALSAGAYESLRRAVHDHEVERRYRALVVGVP-PQAARIEAPLGRDLRDLSR 197

Query: 125 QKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASP 184
             V    G+ A+T+  VV +  D T+ V L   TGR+HQ+RVH+ A+GHPI+GD  Y  P
Sbjct: 198 VAVV-SGGRDARTQLRVVWHGPD-TSLVELTLETGRTHQIRVHLSAIGHPIVGDEVYGVP 255

Query: 185 EARAMAPRLLLHAEMLTITHP 205
                 P   LHA  L   HP
Sbjct: 256 YGGLERP--FLHATALAFEHP 274


>UniRef50_Q7UHX8 Pseudouridine synthase n=1 Tax=Rhodopirellula baltica
           RepID=Q7UHX8_RHOBA
          Length = 334

 Score =  103 bits (256), Expect = 5e-21,   Method: Compositional matrix adjust.
 Identities = 83/244 (34%), Positives = 113/244 (46%), Gaps = 37/244 (15%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGR---LEEHKDSVMTRIQR-----DYPQAESV 60
           P+   L ILY+DD ++V+NKP+G++  P R         ++  R Q         +   V
Sbjct: 74  PENIPLDILYEDDGLVVINKPAGMVVHPARGNWTGTLTSALAFRFQSLSDVGGPTRPGIV 133

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLD  TSGVIVVA   A    L  Q+ +R  +K+Y A  +G        +   +     
Sbjct: 134 HRLDRDTSGVIVVAKNNAVHLNLAAQWHDRLVQKEYTAITFGRLDRDRDWIHASIGRHPY 193

Query: 121 NRPKQKV--CYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGD 178
            R KQ +   + T K A T YEVVE     T RV ++P TGR+HQ+RVH+  +G PIL D
Sbjct: 194 QRDKQAIREGHATSKTASTFYEVVERHGRVT-RVDVRPKTGRTHQIRVHLAHIGCPILCD 252

Query: 179 RFYA-------------------------SPEARA-MAPRLLLHAEMLTITHPAYGNSMT 212
           R Y                          +PE    +  R  LHA+ LT T+P  G  MT
Sbjct: 253 RLYGGHSELSRSQIRRLAGTEVATPGVKPTPEGEEILLSRQALHAKALTFTNPQTGKEMT 312

Query: 213 FKAP 216
             AP
Sbjct: 313 LTAP 316


>UniRef50_C7TK72 Ribosomal large subunit 23S pseudouridine synthase D n=8
           Tax=Lactobacillus RepID=C7TK72_LACRL
          Length = 278

 Score =  103 bits (256), Expect = 5e-21,   Method: Compositional matrix adjust.
 Identities = 73/216 (33%), Positives = 118/216 (54%), Gaps = 15/216 (6%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR---DYPQAESVHRLDM 65
           P+ P L   Y+DD +++V+KP+G+ + P +  E   ++M +       +P A   HRLDM
Sbjct: 71  PETPHLNTRYEDDDLLIVDKPAGMKTHPNQPGE-TGTLMNQAAAYLAPFP-ALITHRLDM 128

Query: 66  ATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPS--PAEGLVDLPLICDWPNRP 123
           ATSG++V+A    A+  + RQ   +   + Y+A V   PS  P +G +  P+  D P+  
Sbjct: 129 ATSGLLVIAKNPLAQAIINRQLTTKTMHRDYLAVV---PSGIPEKGTIQAPIGHD-PDDK 184

Query: 124 KQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYAS 183
           ++++    G  A T Y  +   AD TA + L   TGR+HQ+RVH+ ++G PI+GD  YA+
Sbjct: 185 RKRMIRADGAFAVTHYHRIAETAD-TATIELNLETGRTHQIRVHLASIGFPIIGDPLYAA 243

Query: 184 PEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
            E    A R+ LHA  + +  P     +T  +P+ F
Sbjct: 244 TET---ATRMQLHAFRVRLIRPLTIEPLTVTSPSPF 276


>UniRef50_C0BNA6 Pseudouridine synthase n=7 Tax=Bacteroidetes RepID=C0BNA6_9BACT
          Length = 379

 Score =  103 bits (256), Expect = 5e-21,   Method: Compositional matrix adjust.
 Identities = 79/238 (33%), Positives = 113/238 (47%), Gaps = 36/238 (15%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQ------RDYPQAES--- 59
           P++  L ++Y+D  +MVVNKP G++  PG    H +   T I       +D P       
Sbjct: 127 PEDIPLDVVYEDSDLMVVNKPPGMVVHPG----HGNYSGTLINALLFHVKDLPLNADERP 182

Query: 60  --VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLIC 117
             VHR+D  TSG++VVA T  A   L +QF ++  +++YVA VWG+    +G V   +  
Sbjct: 183 GLVHRIDKDTSGLLVVAKTAKAMTHLAKQFFDKTSEREYVAIVWGNVEEEQGTVRGHIGR 242

Query: 118 DWPNRPKQKVC--YETGKPAQTEYEVVEYAADNT-ARVVLKPITGRSHQLRVHMLALGHP 174
              NR +  V    + GK A T Y+V+E     T    VL+  TGR+HQ+R HM  +GH 
Sbjct: 243 HPKNRLQMAVFPDGDQGKEAVTHYKVMERLGYVTLVSCVLE--TGRTHQIRAHMKHIGHT 300

Query: 175 ILGDRFYASPE----------------ARAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
           +  D  Y   +                A    PR  LHA+ L   HP+ G  M F  P
Sbjct: 301 LFNDERYGGEKILKGTTFTKYKQFVDNAFKALPRQALHAKTLGFVHPSSGELMRFNTP 358


>UniRef50_Q45826 Uncharacterized RNA pseudouridine synthase Caur_0901 n=5
           Tax=Chloroflexi (class) RepID=Y901_CHLAA
          Length = 316

 Score =  103 bits (256), Expect = 5e-21,   Method: Compositional matrix adjust.
 Identities = 74/211 (35%), Positives = 109/211 (51%), Gaps = 12/211 (5%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP--------QAESVHRLDM 65
           L ++Y+D  I V+NKP+G++  P         V   + R YP        +   VHRLD 
Sbjct: 91  LDVVYEDADIAVINKPAGMVVHPAPGHPRGTLVNALLAR-YPDLAIGGELRPGIVHRLDR 149

Query: 66  ATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQ 125
            TSG++V+A    A R L  Q + R  +K Y A V G P P  G +D P+  D  +R + 
Sbjct: 150 DTSGLLVIARHDQAMRSLVDQQQARRMRKIYQALVIGRP-PETGTIDAPIGRDPRDRLRM 208

Query: 126 KVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPE 185
            V  + G+PA+T Y +++   D +  + ++  TGR+HQ+RVH+  LG+PI+GD  Y    
Sbjct: 209 AVVPD-GRPARTHYRLLDTFGDYSL-LEVQLETGRTHQIRVHLRHLGYPIVGDPVYGPRR 266

Query: 186 ARAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
           +     R  LHA  L + HP  G    F AP
Sbjct: 267 SHLHLSRQFLHAAYLGLVHPRSGRWQEFTAP 297


>UniRef50_A6TSZ4 Pseudouridine synthase n=1 Tax=Alkaliphilus metalliredigens QYMF
           RepID=A6TSZ4_ALKMQ
          Length = 308

 Score =  102 bits (255), Expect = 6e-21,   Method: Compositional matrix adjust.
 Identities = 69/220 (31%), Positives = 114/220 (51%), Gaps = 14/220 (6%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESV-------H 61
           PQE    ++Y+D  ++V+NK  G++S P +   H    +    ++Y + + V       +
Sbjct: 81  PQEIPFNVVYEDIDVIVINKEPGIVSHPTK--SHPKDTIANAAQNYLEKKGVACRIRFVN 138

Query: 62  RLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPN 121
           RLDM TSG++V+A        + +Q +  E  K+YVA V G     EG +D   I    +
Sbjct: 139 RLDMDTSGLLVIAKNPYTHHIMSQQMKANEITKKYVAFVKGVVVANEGEID-GAIYRSSD 197

Query: 122 RPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFY 181
              ++V  + G+ + T++ V+E  AD T  + +  +TGR+HQ+RVHM ++GHP+LGD  Y
Sbjct: 198 ETIKRVVDDRGQQSLTKFTVLERYADATM-LEVSLLTGRTHQIRVHMESIGHPMLGDHLY 256

Query: 182 ASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
              +   +  R  LHA  L+   P Y   +  +A  P D 
Sbjct: 257 GYVDTE-LIRRQALHASYLSFLQPRYKEKIEVRASLPKDL 295


>UniRef50_B1H0R5 Pseudouridine synthase n=1 Tax=uncultured Termite group 1 bacterium
           phylotype Rs-D17 RepID=B1H0R5_UNCTG
          Length = 296

 Score =  102 bits (255), Expect = 6e-21,   Method: Compositional matrix adjust.
 Identities = 69/198 (34%), Positives = 102/198 (51%), Gaps = 9/198 (4%)

Query: 24  MVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES----VHRLDMATSGVIVVALTKAA 79
           +VVNK SG++  P     H    +      Y   +     +HRLD  TSGVIV A T+ A
Sbjct: 88  VVVNKRSGIVVHPS--YGHLSGTLLNALMGYSAGKYNPYLIHRLDKDTSGVIVFAKTEKA 145

Query: 80  ERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYETGKPAQTEY 139
           +  + +Q ++R  KK Y A V G  +   G++  PL     NR    V     K A TE+
Sbjct: 146 KISISKQLQKRVVKKIYYAAVKGVIAENRGIIKAPLGRSPKNRKLVSVNPLAKKVAITEF 205

Query: 140 EVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARAM--APRLLLHA 197
           +V+E   D T  + ++ ITGR+HQ+R HM  + HP++GD+ Y  P    +    R +LHA
Sbjct: 206 KVIERKDDYTL-LKVRIITGRTHQIRSHMKYINHPVIGDKQYGGPGTIGLKRCERQMLHA 264

Query: 198 EMLTITHPAYGNSMTFKA 215
             +T THP+   ++ F A
Sbjct: 265 HNITFTHPSTSKTVKFIA 282


Searching..................................................done


Results from round 2


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value
Sequences used in model and found again:

UniRef50_P0AA37 Ribosomal large subunit pseudouridine synthase A...   363   2e-99
UniRef50_B8K915 Pseudouridine synthase n=5 Tax=Vibrio RepID=B8K9...   316   3e-85
UniRef50_Q3ABZ7 Pseudouridine synthase n=2 Tax=Bacteria RepID=Q3...   307   2e-82
UniRef50_Q8DCG0 Ribosomal large subunit pseudouridine synthase A...   306   4e-82
UniRef50_B0TGQ0 Pseudouridine synthase n=44 Tax=Bacteria RepID=B...   305   7e-82
UniRef50_A3MZ33 Pseudouridine synthase n=9 Tax=Proteobacteria Re...   304   2e-81
UniRef50_A7K2Y9 Pseudouridine synthase n=4 Tax=Vibrio RepID=A7K2...   304   2e-81
UniRef50_B8FT16 Pseudouridine synthase n=70 Tax=Bacteria RepID=B...   303   3e-81
UniRef50_B9Y836 Pseudouridine synthase n=3 Tax=Firmicutes RepID=...   299   4e-80
UniRef50_A9CFZ5 Pseudouridine synthase n=3 Tax=Rhizobiales RepID...   295   1e-78
UniRef50_B2UL66 Pseudouridine synthase n=2 Tax=Verrucomicrobiace...   294   1e-78
UniRef50_C4FYR8 Pseudouridine synthase n=1 Tax=Abiotrophia defec...   293   3e-78
UniRef50_A9BFW4 Pseudouridine synthase n=8 Tax=Thermotogaceae Re...   292   4e-78
UniRef50_C7LVL1 Pseudouridine synthase n=5 Tax=Proteobacteria Re...   292   5e-78
UniRef50_C9KPZ8 Pseudouridine synthase n=1 Tax=Mitsuokella multa...   292   6e-78
UniRef50_B8CWM0 Pseudouridine synthase n=1 Tax=Halothermothrix o...   291   9e-78
UniRef50_Q82WZ5 Ribosomal large subunit pseudouridine synthase D...   291   1e-77
UniRef50_P59831 Ribosomal large subunit pseudouridine synthase A...   291   2e-77
UniRef50_C7NAV5 Pseudouridine synthase n=5 Tax=Fusobacteriaceae ...   290   3e-77
UniRef50_Q9JVB6 Ribosomal large subunit pseudouridine synthase D...   289   5e-77
UniRef50_A7HM17 Pseudouridine synthase n=2 Tax=Thermotogaceae Re...   289   7e-77
UniRef50_A3EQJ0 Pseudouridine synthase n=1 Tax=Leptospirillum ru...   288   7e-77
UniRef50_Q6AJM1 Pseudouridine synthase n=1 Tax=Desulfotalea psyc...   287   2e-76
UniRef50_C8NEP8 Pseudouridine synthase n=1 Tax=Granulicatella ad...   287   2e-76
UniRef50_Q45826 Uncharacterized RNA pseudouridine synthase Caur_...   286   3e-76
UniRef50_Q2CAH0 Pseudouridine synthase n=3 Tax=Proteobacteria Re...   286   3e-76
UniRef50_B1I3F8 Pseudouridine synthase n=2 Tax=Bacteria RepID=B1...   285   6e-76
UniRef50_Q2W2D5 Pseudouridine synthase n=39 Tax=Bacteria RepID=Q...   285   6e-76
UniRef50_B6AN83 Pseudouridine synthase n=2 Tax=Leptospirillum Re...   284   1e-75
UniRef50_C8QZ10 Pseudouridine synthase n=1 Tax=Desulfurivibrio a...   284   1e-75
UniRef50_C6XFD0 Pseudouridine synthase n=1 Tax=Candidatus Liberi...   284   2e-75
UniRef50_D1PCC3 Pseudouridine synthase n=1 Tax=Prevotella copri ...   284   2e-75
UniRef50_C9LM35 Pseudouridine synthase n=1 Tax=Dialister invisus...   283   2e-75
UniRef50_Q489H0 Pseudouridine synthase n=3 Tax=Gammaproteobacter...   283   3e-75
UniRef50_P50513 Ribosomal large subunit pseudouridine synthase D...   283   4e-75
UniRef50_C0BNA6 Pseudouridine synthase n=7 Tax=Bacteroidetes Rep...   282   4e-75
UniRef50_B9L028 Pseudouridine synthase n=2 Tax=Thermomicrobia (c...   282   5e-75
UniRef50_B2A2J2 Pseudouridine synthase n=1 Tax=Natranaerobius th...   282   7e-75
UniRef50_Q1MQ60 Pseudouridylate synthases, 23S RNA-specific n=1 ...   282   8e-75
UniRef50_C6BSG2 Pseudouridine synthase, RluA family n=1 Tax=Desu...   280   2e-74
UniRef50_Q2SS88 Pseudouridine synthase n=4 Tax=Mollicutes RepID=...   280   2e-74
UniRef50_A6LDZ7 Pseudouridine synthase n=26 Tax=Bacteroidales Re...   280   2e-74
UniRef50_D2BIX0 Pseudouridine synthase n=5 Tax=Dehalococcoides R...   280   3e-74
UniRef50_A0L9J0 Pseudouridine synthase n=1 Tax=Magnetococcus sp....   279   4e-74
UniRef50_C4FWV7 Pseudouridine synthase n=2 Tax=Firmicutes RepID=...   279   7e-74
UniRef50_A9NGF1 Pseudouridine synthase n=1 Tax=Acholeplasma laid...   278   8e-74
UniRef50_B8E0R4 Pseudouridine synthase n=1 Tax=Dictyoglomus turg...   278   8e-74
UniRef50_A7NB61 Pseudouridine synthase n=18 Tax=Francisella RepI...   278   1e-73
UniRef50_D1ANU4 Pseudouridine synthase n=14 Tax=Fusobacteriaceae...   278   1e-73
UniRef50_Q28K21 Pseudouridine synthase n=11 Tax=Proteobacteria R...   278   1e-73
UniRef50_Q0VQA6 Pseudouridine synthase n=7 Tax=Gammaproteobacter...   278   1e-73
UniRef50_A6C0W7 Pseudouridine synthase n=1 Tax=Planctomyces mari...   277   1e-73
UniRef50_A9BMW0 Pseudouridine synthase n=10 Tax=Comamonadaceae R...   277   1e-73
UniRef50_A6SXT6 Pseudouridine synthase n=1 Tax=Janthinobacterium...   277   1e-73
UniRef50_A9IQ66 Pseudouridine synthase n=5 Tax=Bacteria RepID=A9...   277   2e-73
UniRef50_Q3A0C2 Pseudouridine synthase n=13 Tax=Bacteria RepID=Q...   277   2e-73
UniRef50_Q2LWV4 Pseudouridine synthase n=1 Tax=Syntrophus acidit...   277   3e-73
UniRef50_Q312A0 Pseudouridine synthase, RluD n=6 Tax=Bacteria Re...   276   4e-73
UniRef50_C7RM94 Pseudouridine synthase n=11 Tax=Proteobacteria R...   276   4e-73
UniRef50_A6DUC9 Pseudouridine synthase n=1 Tax=Lentisphaera aran...   275   5e-73
UniRef50_A4VJG2 Pseudouridine synthase n=18 Tax=Bacteria RepID=A...   275   5e-73
UniRef50_A5WFS2 Pseudouridine synthase n=3 Tax=Psychrobacter Rep...   275   5e-73
UniRef50_B9JRD0 Pseudouridine synthase n=1 Tax=Agrobacterium vit...   275   5e-73
UniRef50_A7HV45 Pseudouridine synthase n=56 Tax=Alphaproteobacte...   275   8e-73
UniRef50_Q12L72 Pseudouridine synthase n=17 Tax=Shewanella RepID...   274   1e-72
UniRef50_D0MJ49 Pseudouridine synthase n=2 Tax=Bacteria RepID=D0...   274   1e-72
UniRef50_A3M2Y1 Pseudouridine synthase n=18 Tax=Gammaproteobacte...   274   1e-72
UniRef50_Q1ILA4 Pseudouridine synthase n=1 Tax=Candidatus Koriba...   274   1e-72
UniRef50_B8FLB4 Pseudouridine synthase n=2 Tax=Bacteria RepID=B8...   274   2e-72
UniRef50_D1RB31 Pseudouridine synthase n=1 Tax=Parachlamydia aca...   274   2e-72
UniRef50_C6WV38 Pseudouridine synthase n=3 Tax=Proteobacteria Re...   274   2e-72
UniRef50_A1URK8 Pseudouridine synthase n=2 Tax=Bartonella RepID=...   273   3e-72
UniRef50_O50310 Uncharacterized RNA pseudouridine synthase Cpar_...   273   4e-72
UniRef50_B7BE87 Pseudouridine synthase n=8 Tax=Bacteroidales Rep...   272   4e-72
UniRef50_B8J173 Pseudouridine synthase, RluA family n=2 Tax=Desu...   272   6e-72
UniRef50_D2L0S2 Pseudouridine synthase, RluA family n=1 Tax=Desu...   272   7e-72
UniRef50_C8PVB8 Pseudouridine synthase n=2 Tax=Moraxellaceae Rep...   271   9e-72
UniRef50_Q3AVX8 Pseudouridine synthase n=40 Tax=cellular organis...   271   1e-71
UniRef50_B2RIT5 Pseudouridine synthase n=80 Tax=root RepID=B2RIT...   271   1e-71
UniRef50_Q87AR7 Ribosomal large subunit pseudouridine synthase D...   270   2e-71
UniRef50_C4XSN0 Ribosomal large subunit pseudouridine synthase D...   270   2e-71
UniRef50_Q8XYX8 Ribosomal large subunit pseudouridine synthase D...   270   3e-71
UniRef50_P74346 Uncharacterized RNA pseudouridine synthase slr16...   270   3e-71
UniRef50_D0RPR1 Pseudouridine synthase n=1 Tax=alpha proteobacte...   269   4e-71
UniRef50_C8WW59 Pseudouridine synthase n=2 Tax=Alicyclobacillus ...   269   5e-71
UniRef50_Q31HX2 Pseudouridine synthase n=1 Tax=Thiomicrospira cr...   269   5e-71
UniRef50_D1U4S9 Pseudouridine synthase, RluA family n=1 Tax=Desu...   269   6e-71
UniRef50_A8GQ59 Pseudouridine synthase n=15 Tax=Rickettsia RepID...   269   6e-71
UniRef50_C0QAZ3 RluD1 n=1 Tax=Desulfobacterium autotrophicum HRM...   269   6e-71
UniRef50_A5GW76 Pseudouridine synthase n=1 Tax=Synechococcus sp....   269   7e-71
UniRef50_A8ZXZ8 Pseudouridine synthase n=1 Tax=Desulfococcus ole...   268   9e-71
UniRef50_P65834 Ribosomal large subunit pseudouridine synthase D...   268   1e-70
UniRef50_D1VS73 Pseudouridine synthase n=1 Tax=Peptoniphilus lac...   267   2e-70
UniRef50_B8GZR6 Pseudouridine synthase n=2 Tax=Caulobacter vibri...   267   3e-70
UniRef50_D0KVM5 Pseudouridine synthase n=11 Tax=Proteobacteria R...   267   3e-70
UniRef50_C7H7W3 Ribosomal large subunit pseudouridine synthase D...   266   3e-70
UniRef50_P54604 Uncharacterized RNA pseudouridine synthase yhcT ...   266   3e-70
UniRef50_C1FEQ4 Predicted protein n=2 Tax=Micromonas RepID=C1FEQ...   266   3e-70
UniRef50_D1BAB3 Pseudouridine synthase n=1 Tax=Thermanaerovibrio...   266   3e-70
UniRef50_C8P3R0 Pseudouridine synthase n=1 Tax=Erysipelothrix rh...   266   4e-70
UniRef50_C5VRN0 Pseudouridine synthase n=1 Tax=Clostridium botul...   266   4e-70
UniRef50_C6CWL6 Pseudouridine synthase n=2 Tax=Paenibacillus Rep...   265   5e-70
UniRef50_D1Y3Y9 Pseudouridine synthase n=1 Tax=Pyramidobacter pi...   265   5e-70
UniRef50_A4WSV2 Pseudouridine synthase n=41 Tax=Alphaproteobacte...   265   5e-70
UniRef50_C6XNC0 Pseudouridine synthase n=1 Tax=Hirschia baltica ...   265   5e-70
UniRef50_A0YGE0 Pseudouridine synthase n=1 Tax=marine gamma prot...   265   6e-70
UniRef50_Q01Q94 Pseudouridine synthase n=1 Tax=Candidatus Soliba...   265   7e-70
UniRef50_C9RQF0 Pseudouridine synthase, RluA family n=1 Tax=Fibr...   265   7e-70
UniRef50_B1XN95 Pseudouridine synthase n=1 Tax=Synechococcus sp....   265   7e-70
UniRef50_C7LWM1 Pseudouridine synthase, RluA family n=1 Tax=Desu...   265   1e-69
UniRef50_A5EX53 Pseudouridine synthase n=1 Tax=Dichelobacter nod...   265   1e-69
UniRef50_D1PDP7 Pseudouridine synthase n=1 Tax=Prevotella copri ...   264   1e-69
UniRef50_Q1Q689 Similar to ribosomal large subunit pseudouridine...   264   1e-69
UniRef50_C1ZGS9 Pseudouridine synthase n=1 Tax=Planctomyces limn...   264   1e-69
UniRef50_UPI0001C42CC7 hypothetical protein BpOF4_01845 n=1 Tax=...   264   2e-69
UniRef50_C5BU65 Pseudouridine synthase for 23S rRNA and tRNAphe ...   263   3e-69
UniRef50_Q6MEC0 Pseudouridine synthase n=1 Tax=Candidatus Protoc...   263   3e-69
UniRef50_B7GEZ0 Pseudouridine synthase n=7 Tax=Bacillaceae RepID...   263   3e-69
UniRef50_B1ZYX0 Pseudouridine synthase n=4 Tax=Verrucomicrobia R...   263   3e-69
UniRef50_D1W0M0 Pseudouridine synthase n=1 Tax=Prevotella timone...   263   4e-69
UniRef50_B9YI75 Pseudouridine synthase, RluA family n=1 Tax='Nos...   263   4e-69
UniRef50_Q5PAD0 Pseudouridine synthase n=5 Tax=Anaplasma RepID=Q...   262   4e-69
UniRef50_C0QPR5 Pseudouridine synthase n=4 Tax=Hydrogenothermace...   262   6e-69
UniRef50_C8S0A2 Pseudouridine synthase n=1 Tax=Rhodobacter sp. S...   262   6e-69
UniRef50_Q5E092 Pseudouridine synthase n=3 Tax=Aliivibrio RepID=...   262   7e-69
UniRef50_A8UMR7 Pseudouridine synthase n=1 Tax=Flavobacteriales ...   262   8e-69
UniRef50_Q13E92 Pseudouridine synthase n=28 Tax=Alphaproteobacte...   262   8e-69
UniRef50_Q7UHX8 Pseudouridine synthase n=1 Tax=Rhodopirellula ba...   261   1e-68
UniRef50_B0VJ94 Pseudouridine synthase n=1 Tax=Candidatus Cloaca...   261   1e-68
UniRef50_C7QW59 Pseudouridine synthase n=5 Tax=Cyanobacteria Rep...   261   1e-68
UniRef50_Q1CZL9 Pseudouridine synthase n=5 Tax=Proteobacteria Re...   260   2e-68
UniRef50_A3RGY8 Pseudouridine synthase n=1 Tax=uncultured bacter...   260   2e-68
UniRef50_C6LL16 Pseudouridine synthase n=3 Tax=Clostridiales Rep...   260   2e-68
UniRef50_C6J6E3 Pseudouridine synthase n=2 Tax=Bacillales RepID=...   260   2e-68
UniRef50_C1F7V3 Pseudouridine synthase n=1 Tax=Acidobacterium ca...   260   2e-68
UniRef50_B5YKV0 Pseudouridine synthase n=1 Tax=Thermodesulfovibr...   260   2e-68
UniRef50_C0ZH07 Pseudouridine synthase n=1 Tax=Brevibacillus bre...   260   2e-68
UniRef50_Q1J0S8 Pseudouridine synthase n=7 Tax=Deinococci RepID=...   260   2e-68
UniRef50_C6JBH1 Pseudouridine synthase n=1 Tax=Ruminococcus sp. ...   260   2e-68
UniRef50_A6NQQ9 Pseudouridine synthase n=1 Tax=Bacteroides capil...   260   2e-68
UniRef50_O67638 Uncharacterized RNA pseudouridine synthase aq_17...   260   2e-68
UniRef50_C1A885 Pseudouridine synthase n=1 Tax=Gemmatimonas aura...   260   2e-68
UniRef50_B0JGC2 Pseudouridine synthase n=2 Tax=Microcystis aerug...   260   3e-68
UniRef50_Q26D11 Pseudouridine synthase n=2 Tax=Flavobacteria Rep...   260   3e-68
UniRef50_Q0F3G2 Possible pseudouridine synthase n=1 Tax=Mariprof...   260   3e-68
UniRef50_B7VRG6 Pseudouridine synthase n=4 Tax=Vibrionales RepID...   259   4e-68
UniRef50_Q2S3B7 Pseudouridine synthase n=1 Tax=Salinibacter rube...   259   4e-68
UniRef50_Q0F1Z5 Pseudouridine synthase n=1 Tax=Mariprofundus fer...   259   5e-68
UniRef50_Q4FN11 Pseudouridine synthase n=4 Tax=Bacteria RepID=Q4...   259   5e-68
UniRef50_Q2GGY1 Pseudouridine synthase n=13 Tax=Rickettsiales Re...   259   5e-68
UniRef50_D2R7T3 Pseudouridine synthase, RluA family n=1 Tax=Pire...   259   6e-68
UniRef50_C0ZCK6 Pseudouridine synthase n=1 Tax=Brevibacillus bre...   259   6e-68
UniRef50_A6VZC6 Pseudouridine synthase n=2 Tax=Marinomonas RepID...   259   6e-68
UniRef50_B7GLK3 Pseudouridine synthase n=11 Tax=Bacillaceae RepI...   258   1e-67
UniRef50_C1AE05 Pseudouridine synthase n=1 Tax=Gemmatimonas aura...   258   1e-67
UniRef50_C1SM47 Pseudouridine synthase n=1 Tax=Denitrovibrio ace...   258   1e-67
UniRef50_A5ZGG0 Pseudouridine synthase n=4 Tax=Bacteroides RepID...   258   1e-67
UniRef50_Q03WF6 Pseudouridine synthase n=9 Tax=Firmicutes RepID=...   258   1e-67
UniRef50_A1AW00 Pseudouridine synthase n=2 Tax=sulfur-oxidizing ...   258   1e-67
UniRef50_B6BTN1 Pseudouridine synthase n=2 Tax=Betaproteobacteri...   257   1e-67
UniRef50_A1HR26 Pseudouridine synthase, RluA family n=1 Tax=Ther...   257   2e-67
UniRef50_A0Q1S9 Pseudouridine synthase n=32 Tax=Clostridium RepI...   257   2e-67
UniRef50_A0LPH5 Pseudouridine synthase n=1 Tax=Syntrophobacter f...   257   2e-67
UniRef50_C0GNZ6 Pseudouridine synthase, RluA family n=1 Tax=Desu...   257   2e-67
UniRef50_Q2NIN6 Pseudouridine synthase n=4 Tax=Candidatus Phytop...   257   2e-67
UniRef50_C5VJ38 Pseudouridine synthase n=2 Tax=Prevotella RepID=...   257   2e-67
UniRef50_A8MF48 Pseudouridine synthase n=12 Tax=Clostridiaceae R...   257   3e-67
UniRef50_B8CWB7 Pseudouridine synthase n=1 Tax=Halothermothrix o...   257   3e-67
UniRef50_B1Y046 Pseudouridine synthase n=43 Tax=Proteobacteria R...   256   3e-67
UniRef50_A9BWX6 Pseudouridine synthase n=2 Tax=Comamonadaceae Re...   256   4e-67
UniRef50_C7PHX6 Pseudouridine synthase n=1 Tax=Chitinophaga pine...   256   4e-67
UniRef50_B3DV48 Pseudouridine synthase n=1 Tax=Methylacidiphilum...   256   4e-67
UniRef50_A4RT55 Predicted protein (Fragment) n=3 Tax=Chlorophyta...   256   4e-67
UniRef50_C2W5F3 Pseudouridine synthase n=4 Tax=Bacillus RepID=C2...   256   4e-67
UniRef50_Q6FCX9 Pseudouridine synthase n=1 Tax=Acinetobacter sp....   256   4e-67
UniRef50_C8X1I9 Pseudouridine synthase, RluA family n=1 Tax=Desu...   256   4e-67
UniRef50_Q63E77 Pseudouridine synthase n=73 Tax=Bacillaceae RepI...   255   5e-67
UniRef50_C5J6Q2 Pseudouridine synthase n=1 Tax=Mycoplasma conjun...   255   7e-67
UniRef50_C9M7B4 Pseudouridine synthase n=1 Tax=Jonquetella anthr...   255   7e-67
UniRef50_B0VCN8 Pseudouridine synthase n=16 Tax=Acinetobacter Re...   255   7e-67
UniRef50_A6TAT3 Pseudouridine synthase n=57 Tax=Bacteria RepID=A...   255   8e-67
UniRef50_D1PU24 Pseudouridine synthase n=1 Tax=Prevotella bergen...   255   1e-66
UniRef50_B8DF66 Pseudouridine synthase n=18 Tax=Listeria RepID=B...   255   1e-66
UniRef50_B7HGW1 Pseudouridine synthase n=52 Tax=Bacillales RepID...   254   1e-66
UniRef50_D0MK65 Pseudouridine synthase n=1 Tax=Rhodothermus mari...   254   1e-66
UniRef50_A5VJ18 Pseudouridine synthase, RluA family n=13 Tax=Lac...   254   1e-66
UniRef50_Q31NG5 Pseudouridine synthase n=2 Tax=Synechococcus elo...   254   1e-66
UniRef50_D1N7N8 Pseudouridine synthase, RluA family n=1 Tax=Vict...   254   1e-66
UniRef50_A5IBH6 Pseudouridine synthase n=6 Tax=Legionella RepID=...   254   1e-66
UniRef50_Q0BWH2 Pseudouridine synthase n=3 Tax=Alphaproteobacter...   254   1e-66
UniRef50_C0Z877 Pseudouridine synthase n=1 Tax=Brevibacillus bre...   254   1e-66
UniRef50_C0MA80 Pseudouridine synthase n=6 Tax=Streptococcus Rep...   254   2e-66
UniRef50_B6J6C4 Pseudouridine synthase n=7 Tax=Coxiella burnetii...   254   2e-66
UniRef50_P59838 Ribosomal large subunit pseudouridine synthase D...   253   2e-66
UniRef50_O31613 Uncharacterized RNA pseudouridine synthase yjbO ...   253   3e-66
UniRef50_D1CBT6 Pseudouridine synthase n=1 Tax=Thermobaculum ter...   253   4e-66
UniRef50_C1CWT3 Pseudouridine synthase n=1 Tax=Deinococcus deser...   252   5e-66
UniRef50_UPI00016C3FBA ribosomal large subunit pseudouridine syn...   252   7e-66
UniRef50_Q6MGX8 Pseudouridine synthase n=1 Tax=Bdellovibrio bact...   252   7e-66
UniRef50_D1AV01 Pseudouridine synthase n=2 Tax=Bacteria RepID=D1...   251   1e-65
UniRef50_B8FTI5 Pseudouridine synthase n=2 Tax=Desulfitobacteriu...   251   1e-65
UniRef50_C6BRU5 Pseudouridine synthase n=1 Tax=Desulfovibrio sal...   251   1e-65
UniRef50_Q8ERS8 Pseudouridine synthase n=2 Tax=Bacillaceae RepID...   251   1e-65
UniRef50_Q8K9E9 Ribosomal large subunit pseudouridine synthase D...   250   2e-65
UniRef50_B7I1Q3 Dual specificity pseudouridine synthase n=17 Tax...   250   2e-65
UniRef50_Q8ZQ16 Ribosomal large subunit pseudouridine synthase C...   250   2e-65
UniRef50_B2KBB0 Pseudouridine synthase n=1 Tax=Elusimicrobium mi...   250   2e-65
UniRef50_Q14NK8 Probable pseudouridine synthase d protein n=1 Ta...   250   2e-65
UniRef50_A6FXR5 Pseudouridine synthase n=1 Tax=Plesiocystis paci...   250   3e-65
UniRef50_A4J479 Pseudouridine synthase n=1 Tax=Desulfotomaculum ...   250   3e-65
UniRef50_C5RBB6 23S rRNA pseudouridylate synthase RluD n=1 Tax=W...   249   4e-65
UniRef50_B4U613 Pseudouridine synthase, RluA family n=1 Tax=Hydr...   249   4e-65
UniRef50_Q1WS43 Pseudouridine synthase n=3 Tax=Lactobacillus Rep...   249   5e-65
UniRef50_C8NZX3 Pseudouridine synthase n=1 Tax=Erysipelothrix rh...   249   5e-65
UniRef50_Q12RE8 Pseudouridine synthase n=83 Tax=Bacteria RepID=Q...   249   5e-65
UniRef50_D2M2K8 Pseudouridine synthase, RluA family n=1 Tax=Baci...   249   7e-65
UniRef50_C5WJF2 Pseudouridine synthase n=104 Tax=Lactobacillales...   248   9e-65
UniRef50_A0Y082 Pseudouridine synthase n=2 Tax=Alteromonadales R...   248   9e-65
UniRef50_Q83G23 Pseudouridine synthase n=2 Tax=Tropheryma whippl...   248   1e-64
UniRef50_C7GZW0 Pseudouridine synthase n=1 Tax=Eubacterium saphe...   248   1e-64
UniRef50_C2L1H2 Pseudouridine synthase n=1 Tax=Oribacterium sinu...   247   1e-64
UniRef50_A8RHQ2 Pseudouridine synthase n=2 Tax=Clostridium RepID...   247   1e-64
UniRef50_D0P480 Ribosomal large subunit pseudouridine synthase A...   247   2e-64
UniRef50_D2RBY1 Pseudouridine synthase, RluA family n=1 Tax=Gard...   247   2e-64
UniRef50_A6TSZ4 Pseudouridine synthase n=1 Tax=Alkaliphilus meta...   247   3e-64
UniRef50_B9DS29 Pseudouridine synthase n=85 Tax=Firmicutes RepID...   246   4e-64
UniRef50_Q5QZ45 Pseudouridine synthase n=2 Tax=Gammaproteobacter...   245   6e-64
UniRef50_B1XXM0 Pseudouridine synthase n=6 Tax=Burkholderiales R...   245   6e-64
UniRef50_A4J1I1 Pseudouridine synthase n=1 Tax=Desulfotomaculum ...   245   6e-64
UniRef50_Q9KQH0 Ribosomal large subunit pseudouridine synthase C...   245   8e-64
UniRef50_C0EHV8 Putative uncharacterized protein n=1 Tax=Clostri...   245   9e-64
UniRef50_P70870 Ribosomal large subunit pseudouridine synthase D...   244   1e-63
UniRef50_C9KIU1 Pseudouridine synthase n=3 Tax=Veillonellaceae R...   244   1e-63
UniRef50_B5YAZ5 Pseudouridine synthase n=2 Tax=Dictyoglomus RepI...   244   1e-63
UniRef50_C8Q1E7 Pseudouridine synthase n=1 Tax=Enhydrobacter aer...   244   1e-63
UniRef50_Q38W13 Pseudouridine synthase n=4 Tax=Lactobacillus Rep...   244   2e-63
UniRef50_C4V3I7 Pseudouridine synthase n=1 Tax=Selenomonas flueg...   244   2e-63
UniRef50_B2J8D4 Pseudouridine synthase n=7 Tax=Cyanobacteria Rep...   244   2e-63
UniRef50_Q8ZFU1 Ribosomal large subunit pseudouridine synthase C...   244   2e-63
UniRef50_D1XZI5 Pseudouridine synthase n=1 Tax=Prevotella bivia ...   244   2e-63
UniRef50_A9IIW7 Pseudouridine synthase n=5 Tax=Bordetella RepID=...   244   2e-63
UniRef50_Q0F3G4 Pseudouridine synthase n=1 Tax=Mariprofundus fer...   243   3e-63
UniRef50_Q2RQY9 Pseudouridine synthase n=3 Tax=Alphaproteobacter...   243   3e-63

Sequences not found previously or not previously below threshold:

UniRef50_Q49WX8 Pseudouridine synthase n=1 Tax=Staphylococcus sa...   268   8e-71
UniRef50_D0J9U5 Pseudouridine synthase n=2 Tax=Blattabacterium R...   265   8e-70
UniRef50_C0QV86 Pseudouridine synthase n=2 Tax=Brachyspira RepID...   260   2e-68
UniRef50_C4XFS9 Pseudouridine synthase n=2 Tax=Mycoplasma RepID=...   257   2e-67
UniRef50_B0K860 Pseudouridine synthase n=11 Tax=Thermoanaerobact...   250   3e-65
UniRef50_A5IZB6 Pseudouridine synthase n=4 Tax=Mycoplasma RepID=...   248   9e-65
UniRef50_A5ZUU7 Pseudouridine synthase n=1 Tax=Ruminococcus obeu...   246   4e-64

>UniRef50_P0AA37 Ribosomal large subunit pseudouridine synthase A n=205
           Tax=Proteobacteria RepID=RLUA_ECOLI
          Length = 219

 Score =  363 bits (933), Expect = 2e-99,   Method: Composition-based stats.
 Identities = 219/219 (100%), Positives = 219/219 (100%)

Query: 1   MGMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESV 60
           MGMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESV
Sbjct: 1   MGMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESV 60

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP
Sbjct: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120

Query: 121 NRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRF 180
           NRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRF
Sbjct: 121 NRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRF 180

Query: 181 YASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
           YASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF
Sbjct: 181 YASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219


>UniRef50_B8K915 Pseudouridine synthase n=5 Tax=Vibrio RepID=B8K915_VIBPA
          Length = 254

 Score =  316 bits (812), Expect = 3e-85,   Method: Composition-based stats.
 Identities = 125/219 (57%), Positives = 157/219 (71%), Gaps = 1/219 (0%)

Query: 1   MGMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESV 60
           M M  YNPP+EPW+ I+++D+HI+V NKPSGLLSVPGRLEEH DS+ +R+   YP  + V
Sbjct: 10  MAMTEYNPPREPWVDIVFEDEHILVANKPSGLLSVPGRLEEHYDSLWSRLVAIYPDIQVV 69

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLDM TSG++++A  K AER LK+QF+ R   K Y ARVWGHP+   G +DLPLICDWP
Sbjct: 70  HRLDMDTSGLMLLAKHKEAERSLKKQFQYRLTHKVYYARVWGHPTNDNGEIDLPLICDWP 129

Query: 121 NRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRF 180
           NRP+Q VC++ GKP++T Y+VV+   + T+ V L PITGRSHQLRVHM ALGHPI+GD F
Sbjct: 130 NRPRQIVCFDDGKPSKTLYQVVKR-EERTSIVRLLPITGRSHQLRVHMQALGHPIVGDEF 188

Query: 181 YASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
           Y+  EA   + RL LHA  L+  HP          P DF
Sbjct: 189 YSEGEAFEFSDRLELHAAELSFYHPHSEALQCAFVPCDF 227


>UniRef50_Q3ABZ7 Pseudouridine synthase n=2 Tax=Bacteria RepID=Q3ABZ7_CARHZ
          Length = 305

 Score =  307 bits (787), Expect = 2e-82,   Method: Composition-based stats.
 Identities = 75/218 (34%), Positives = 109/218 (50%), Gaps = 9/218 (4%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYPQAESV 60
           P+E  L I+Y+D+ ++VVNK +G++  P         V   +             +   V
Sbjct: 77  PEEIPLDIVYEDEDLVVVNKKAGMVVHPAEGNWDGTLVNALLYHCQNLSGIGGVLRPGIV 136

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLD  TSG++VVA    A + L  Q +E++  ++Y   V G+    EG++DLP+     
Sbjct: 137 HRLDKDTSGLLVVAKNDLAHQSLAEQIKEKKAVREYWTIVHGYLKNKEGIIDLPIGRHPR 196

Query: 121 NRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRF 180
           +R K  V    GK AQT Y+V+E        +  K +TGR+HQ+RVH   LGHP+LGD  
Sbjct: 197 DRQKMAVV-SNGKTAQTVYKVLEEFNKGFTLIQAKLLTGRTHQIRVHFSYLGHPVLGDPK 255

Query: 181 YASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           Y          R +LHA  L+  HP  G  + F AP  
Sbjct: 256 YGHQNNPFGVKRQMLHAIKLSFIHPRSGELLEFTAPLP 293


>UniRef50_Q8DCG0 Ribosomal large subunit pseudouridine synthase A n=82
           Tax=Proteobacteria RepID=RLUA_VIBVU
          Length = 250

 Score =  306 bits (785), Expect = 4e-82,   Method: Composition-based stats.
 Identities = 122/223 (54%), Positives = 151/223 (67%), Gaps = 4/223 (1%)

Query: 1   MGMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESV 60
           M M  Y PP +PW  I+++DDHI+ VNKPSGLLSVPGRL EH DS+ +R+Q  YP+ + V
Sbjct: 1   MAMLEYLPPTDPWTEIIFEDDHILAVNKPSGLLSVPGRLPEHHDSMWSRLQEQYPEIQVV 60

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLDM+TSG++V A  K AE  LK+QF+ R   K Y ARVWGH     G++DLPLICDWP
Sbjct: 61  HRLDMSTSGLMVFAKNKRAEAALKKQFQYRLTHKVYYARVWGHVEADSGMIDLPLICDWP 120

Query: 121 NRPKQKVCYETGKPAQTEYEVVEY----AADNTARVVLKPITGRSHQLRVHMLALGHPIL 176
           NRP QKVC+E GKP+QT ++V +         T  + L P+TGRSHQLRVHM ALGHPI+
Sbjct: 121 NRPMQKVCHEHGKPSQTAFQVAKREVHANGAQTTIMRLLPVTGRSHQLRVHMQALGHPIV 180

Query: 177 GDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
           GD FYA  +A   + RL LHA  L+  HP      +   P DF
Sbjct: 181 GDEFYAQGDAFTFSERLELHAAELSFYHPKSHWLRSLFVPCDF 223


>UniRef50_B0TGQ0 Pseudouridine synthase n=44 Tax=Bacteria RepID=B0TGQ0_HELMI
          Length = 369

 Score =  305 bits (782), Expect = 7e-82,   Method: Composition-based stats.
 Identities = 70/222 (31%), Positives = 104/222 (46%), Gaps = 12/222 (5%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYPQAESV 60
           P++  L I++QD  I V+NKP+GL+  P         V   +             +   V
Sbjct: 107 PEDIPLEIIFQDADIAVINKPAGLVVHPAEGHWSGTLVNALLYHIKDLSGINGELRPGIV 166

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HR+D  TSG++VVA    A   L  Q ++   +++Y+A V G      G V+ P+  D  
Sbjct: 167 HRIDKDTSGLLVVAKNDRAHIHLTEQVKDHRVRREYLAVVHGVIGAETGRVEAPIGRDPK 226

Query: 121 NRPKQKVCYETGKPAQTEYEVV-EYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDR 179
           +R +  V    GK A T + V+  Y     + +  +  TGR+HQ+RVH+  +GHP+ GD 
Sbjct: 227 DRQRMAVI-AGGKSAITHFRVLARYPEQGFSLLHCRLETGRTHQIRVHLAHIGHPVAGDP 285

Query: 180 FYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
            Y   +A        LHA  L   HP  G  M F+A  P  F
Sbjct: 286 KYGPRKAAFGLTGQALHAWKLEFVHPRSGEPMRFQADPPEPF 327


>UniRef50_A3MZ33 Pseudouridine synthase n=9 Tax=Proteobacteria RepID=A3MZ33_ACTP2
          Length = 237

 Score =  304 bits (780), Expect = 2e-81,   Method: Composition-based stats.
 Identities = 136/222 (61%), Positives = 170/222 (76%), Gaps = 3/222 (1%)

Query: 1   MGMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESV 60
           M +  Y+PP EP+L  +Y+D+HI+V+NKPSGLLSVPG   E+ DS MTR+Q+ Y   E  
Sbjct: 16  MALIEYHPPLEPFLTEVYRDNHILVINKPSGLLSVPGNRPEYYDSAMTRVQQKYGFTEPA 75

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSP---AEGLVDLPLIC 117
           HRLDMATSG+++ AL+KAAE+ELKRQFR+REPKK Y+A +WG         G ++ PLIC
Sbjct: 76  HRLDMATSGILLFALSKAAEKELKRQFRDREPKKHYIALLWGKLGEKVGDTGEMNFPLIC 135

Query: 118 DWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILG 177
           DW NRP+QK+CYE GK A T YEV+ +  +NT RV L PITGRSHQLRVH LALGHPILG
Sbjct: 136 DWENRPRQKICYERGKKAITHYEVLAHLPNNTTRVKLTPITGRSHQLRVHSLALGHPILG 195

Query: 178 DRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
           D+FYASP A++++PRL LHAE L+ITHP  G +MTF A  +F
Sbjct: 196 DKFYASPLAKSLSPRLCLHAESLSITHPITGEAMTFTAQTEF 237


>UniRef50_A7K2Y9 Pseudouridine synthase n=4 Tax=Vibrio RepID=A7K2Y9_VIBSE
          Length = 250

 Score =  304 bits (779), Expect = 2e-81,   Method: Composition-based stats.
 Identities = 121/223 (54%), Positives = 159/223 (71%), Gaps = 4/223 (1%)

Query: 1   MGMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESV 60
           M M  Y PP +PW+ I+++DD I+ VNKPSGLLSVPGRL EH DS+ +R++  +P+ + V
Sbjct: 1   MAMLEYTPPTDPWVDIVFEDDDILAVNKPSGLLSVPGRLAEHYDSMWSRLKEVHPEIQVV 60

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLDM+TSG++++A  K +ER LK+QF+ R   K Y ARVWGH  P EG +DLPLICDWP
Sbjct: 61  HRLDMSTSGLMLLAKNKPSERALKKQFQYRLTHKVYYARVWGHVEPQEGNIDLPLICDWP 120

Query: 121 NRPKQKVCYETGKPAQTEYEVVEYA----ADNTARVVLKPITGRSHQLRVHMLALGHPIL 176
           NRP+QKVC++ GKP+QT ++VV+        +T  V L PITGRSHQLRVH++A+GH I+
Sbjct: 121 NRPRQKVCFDDGKPSQTLFQVVKREVHSDGTHTTVVRLLPITGRSHQLRVHLMAIGHAIV 180

Query: 177 GDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
           GD FYA+ EA   + RL LHA  L+  HPA     +   P DF
Sbjct: 181 GDEFYATEEAYQFSERLELHAAELSFYHPATDQLSSIFVPCDF 223


>UniRef50_B8FT16 Pseudouridine synthase n=70 Tax=Bacteria RepID=B8FT16_DESHD
          Length = 334

 Score =  303 bits (777), Expect = 3e-81,   Method: Composition-based stats.
 Identities = 73/216 (33%), Positives = 105/216 (48%), Gaps = 9/216 (4%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYPQAESVH 61
           +   L ILY+D+ ++VVNK  G++  P      K  V   +             +   VH
Sbjct: 103 ENIPLEILYEDEDVLVVNKSQGMVVHPAPGAWTKTLVNALLYHCRNLSGINGVLRPGIVH 162

Query: 62  RLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPN 121
           R+D  TSG++VVA    A + L  Q +     ++Y+A V G      G V+ P+  D  +
Sbjct: 163 RIDKDTSGLLVVAKNDLAHQGLAEQIKAHSMARRYLAIVHGVVFEPSGTVEAPIGRDPAD 222

Query: 122 RPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFY 181
           R K  V ++  K A T YEV+E   D    +  +  TGR+HQ+RVHM  L HP+LGD  Y
Sbjct: 223 RKKMAVVFQNAKEAVTHYEVLERFRD-FTLLEARLETGRTHQIRVHMAYLKHPVLGDPLY 281

Query: 182 ASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPA 217
              +        +LHA++L   HP  G  M F APA
Sbjct: 282 GPRKNPFGLQGQMLHAQLLGFQHPRSGEYMEFSAPA 317


>UniRef50_B9Y836 Pseudouridine synthase n=3 Tax=Firmicutes RepID=B9Y836_9FIRM
          Length = 307

 Score =  299 bits (768), Expect = 4e-80,   Method: Composition-based stats.
 Identities = 77/218 (35%), Positives = 111/218 (50%), Gaps = 10/218 (4%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYPQAESV 60
           PQE  L ++Y+D  ++V+NKP GL+  PG        V   +             +   V
Sbjct: 75  PQEMALNVVYEDHDVIVINKPKGLVVHPGPGNPDHTLVNGLLWHCHDLSGINGVLRPGIV 134

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HR+D  TSG+IV      A + L +Q  E+   +QY A V G  +   G +D P+  D  
Sbjct: 135 HRIDKDTSGLIVACKNDNAHQSLAKQLAEKTAGRQYYALVHGVINHEYGTIDAPIGRDEK 194

Query: 121 NRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRF 180
           +R K  V  +  +PA T ++VVE   DN   V  +  TGR+HQ+RVHM  +G PI+GD  
Sbjct: 195 DRQKMAVTEKNSRPAITHFKVVERF-DNYTLVSCRLETGRTHQIRVHMQYIGFPIVGDPK 253

Query: 181 YASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           Y+  +        +LHA  L+ THP+ G  MTF+AP  
Sbjct: 254 YSLRKTLPT-QGQMLHAYQLSFTHPSTGERMTFEAPLP 290


>UniRef50_A9CFZ5 Pseudouridine synthase n=3 Tax=Rhizobiales RepID=A9CFZ5_AGRT5
          Length = 222

 Score =  295 bits (756), Expect = 1e-78,   Method: Composition-based stats.
 Identities = 108/214 (50%), Positives = 148/214 (69%), Gaps = 1/214 (0%)

Query: 6   YNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDM 65
           YNPP +PWL I+++DD ++V++KPSGLLSVPGR     DS+MTR+Q+ +P+A  ++RLD 
Sbjct: 10  YNPPLDPWLTIVHRDDDLLVLDKPSGLLSVPGRDPALSDSLMTRVQKQFPKALMINRLDK 69

Query: 66  ATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQ 125
            TSG+++++L + A   +  QF +RE +K YVA VWG  +  EG VDLPL  D  N+P+ 
Sbjct: 70  DTSGIVLMSLNRKAHAAIAAQFEKRETRKSYVAIVWGTVAGEEGEVDLPLAIDPDNKPRH 129

Query: 126 KVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPE 185
           +V +E GKPAQ+ + V+E       R+ L P+TGR+HQLRVHM ALGHPILGD FYA  E
Sbjct: 130 RVDHENGKPAQSLWRVLERLPLPATRLALTPLTGRTHQLRVHMKALGHPILGDEFYAEGE 189

Query: 186 ARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
           A   APRL+LHA+ +   HP  G  +T+  P  F
Sbjct: 190 ALTAAPRLMLHAQEVGFRHP-DGRDVTYTVPCPF 222


>UniRef50_B2UL66 Pseudouridine synthase n=2 Tax=Verrucomicrobiaceae
           RepID=B2UL66_AKKM8
          Length = 323

 Score =  294 bits (754), Expect = 1e-78,   Method: Composition-based stats.
 Identities = 81/221 (36%), Positives = 115/221 (52%), Gaps = 11/221 (4%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYPQAESV 60
           PQ+  L ILY+D+ ++V+NK SG++  P         V   +             +   V
Sbjct: 72  PQDIPLDILYEDEDVVVINKESGMVVHPAAGNPDGTIVNALLHHCGDLSGIGGVERPGIV 131

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLD  TSG +V+A    A + L  QF  R  +K+Y+A V G PS + G V   +     
Sbjct: 132 HRLDKDTSGCLVIAKNDGAHQSLTAQFAARSTEKRYLAVVQGIPSQSSGTVFTHIGRHPV 191

Query: 121 NRPKQKVCYET-GKPAQTEYEVV-EYAADNTARVVLKPITGRSHQLRVHMLALGHPILGD 178
           NR K  V     GK A T+Y+++    + +++ V+    TGR+HQ+RVHML LGHP++GD
Sbjct: 192 NRLKMAVVNPGSGKAAITDYDLLCADPSTDSSLVLCTLHTGRTHQIRVHMLYLGHPLIGD 251

Query: 179 RFYASPEARAMAP-RLLLHAEMLTITHPAYGNSMTFKAPAD 218
             YA P  +   P RL+LHA  L   HP  G  M F+AP  
Sbjct: 252 PIYAKPARQKAKPGRLMLHAWRLGFDHPRTGKRMDFEAPVP 292


>UniRef50_C4FYR8 Pseudouridine synthase n=1 Tax=Abiotrophia defectiva ATCC 49176
           RepID=C4FYR8_ABIDE
          Length = 326

 Score =  293 bits (751), Expect = 3e-78,   Method: Composition-based stats.
 Identities = 72/223 (32%), Positives = 107/223 (47%), Gaps = 14/223 (6%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR---------DYPQAES 59
           P+   L ILY+D+ ++++NKP G++  P         V   +              +   
Sbjct: 94  PENIPLDILYEDEDVILINKPKGMVVHPAAGHYTGTLVNALMYHCRDNLSGINGELRPGI 153

Query: 60  VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDW 119
           VHR+DM T+GVI+      + R +  Q +E   K++Y A V+G     EG ++  +    
Sbjct: 154 VHRIDMDTTGVIIACKNDVSHRIIAEQLKEHSIKRKYQAIVYGVFKDEEGRIEGSIGRSK 213

Query: 120 PNRPKQKVCYETGKPAQTEYEVVEYA----ADNTARVVLKPITGRSHQLRVHMLALGHPI 175
            +R K  V    GKPA T Y V+        +N A +  +  TGR+HQ+RVHM ++GHP+
Sbjct: 214 TDRKKMAVI-PDGKPAVTHYRVIRNYTSPNGNNFAHIECELETGRTHQIRVHMTSIGHPL 272

Query: 176 LGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           LGD  Y + +         LHAEML   HP  G  M F AP  
Sbjct: 273 LGDEIYGAAKNPFKLDGQALHAEMLGFVHPRTGEYMEFHAPLP 315


>UniRef50_A9BFW4 Pseudouridine synthase n=8 Tax=Thermotogaceae RepID=A9BFW4_PETMO
          Length = 319

 Score =  292 bits (750), Expect = 4e-78,   Method: Composition-based stats.
 Identities = 78/228 (34%), Positives = 112/228 (49%), Gaps = 14/228 (6%)

Query: 4   ENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR---------DY 54
           E    P+   L ILY+D+ ++V+NKP+GL+  P    +    V   +           D 
Sbjct: 75  EENILPENIPLNILYEDEELIVINKPAGLIVHPTPSIKTGTLVNALMHHVKDLDKTMQDP 134

Query: 55  PQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLP 114
            +   VHRLD  TSGV+VVA    +   L ++F+ER+  K Y+A V G     EG ++LP
Sbjct: 135 NRLGIVHRLDKETSGVLVVAKNAFSHHLLSKEFKERKTMKYYLAIVEGTLKEKEGEINLP 194

Query: 115 LICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHP 174
           L      R K+ V Y  GK A TEY+ ++   D    V ++  TGR+HQ+RVH   +G+P
Sbjct: 195 LGRHPILRHKRAVVY-NGKEAITEYKTLKEFGDLATLVWIRLRTGRTHQIRVHFKYIGNP 253

Query: 175 ILGDRFYASPEARAMAP----RLLLHAEMLTITHPAYGNSMTFKAPAD 218
           ++GD  Y   +          R +LHA  L   HP     M F AP  
Sbjct: 254 LIGDSLYGKNKIEKNLQIPVGRQMLHALKLGFYHPKTKEWMEFLAPLP 301


>UniRef50_C7LVL1 Pseudouridine synthase n=5 Tax=Proteobacteria RepID=C7LVL1_DESBD
          Length = 234

 Score =  292 bits (749), Expect = 5e-78,   Method: Composition-based stats.
 Identities = 118/214 (55%), Positives = 153/214 (71%), Gaps = 4/214 (1%)

Query: 6   YNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDM 65
           Y+PP EP L ++++D  ++VVNKPSGLLSVPGR  E  DSV++R++  +  A++VHRLD+
Sbjct: 8   YDPPTEPRLAVIHEDRDMVVVNKPSGLLSVPGRTPELFDSVLSRVREIHRGAQAVHRLDL 67

Query: 66  ATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQ 125
            TSGV+VVA  + AE  L++QF++R  +K Y+ARV G  S   G VDLPLICDWPNRP Q
Sbjct: 68  GTSGVLVVATRRKAETILRQQFQDRLTRKLYLARVQGVMSEDSGQVDLPLICDWPNRPMQ 127

Query: 126 KVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPE 185
            VC++TGKPA T+Y+V+E   ++T  V+L+P TGRSHQLRVHM +LGHPILGD  Y    
Sbjct: 128 MVCHDTGKPALTDYQVLESDGEST-LVLLRPHTGRSHQLRVHMASLGHPILGDNLYG--- 183

Query: 186 ARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
            +    RLLLHA  L + HP  G   TF AP DF
Sbjct: 184 EQRPGERLLLHASQLGLYHPYSGEWTTFHAPCDF 217


>UniRef50_C9KPZ8 Pseudouridine synthase n=1 Tax=Mitsuokella multacida DSM 20544
           RepID=C9KPZ8_9FIRM
          Length = 308

 Score =  292 bits (748), Expect = 6e-78,   Method: Composition-based stats.
 Identities = 75/219 (34%), Positives = 106/219 (48%), Gaps = 10/219 (4%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYPQAESV 60
           P++  L ILY+D  I+V+NK  G++  P         V   +             +   V
Sbjct: 75  PEDIPLDILYEDSDIIVINKARGMVVHPATGIYTGTLVNALLYHCKDLSGINGEIRPGIV 134

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLD  TSGV+V A   AA  +L  Q R +   + Y A V G+     G++   +     
Sbjct: 135 HRLDKDTSGVMVAAKNDAAHLDLAEQIRTKAAHRIYRAIVCGNIREEAGVIKGDIGRHPT 194

Query: 121 NRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRF 180
           +R K  + +E GKPA T + V+E        V  +  TGR+HQ+RVHM ++GHP+LGD  
Sbjct: 195 DRKKMAIVHEHGKPAVTHFRVLERFGA-YTLVECRLETGRTHQIRVHMASIGHPVLGDPK 253

Query: 181 YASPEARAMA-PRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           Y   +A   A     LH+  LT+THP     MTF AP  
Sbjct: 254 YGPRKACPFAIKGQALHSLQLTLTHPRTREVMTFTAPLP 292


>UniRef50_B8CWM0 Pseudouridine synthase n=1 Tax=Halothermothrix orenii H 168
           RepID=B8CWM0_HALOH
          Length = 308

 Score =  291 bits (747), Expect = 9e-78,   Method: Composition-based stats.
 Identities = 77/228 (33%), Positives = 119/228 (52%), Gaps = 13/228 (5%)

Query: 3   MENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDY-------- 54
            ++   P E  L I+Y+D  I+V+NK +GL+  P     H+++++  +            
Sbjct: 71  EDSGIKPVEMDLDIIYEDKDILVLNKNAGLVVHPAPG-NHENTLVNALIAYCDNLSTISG 129

Query: 55  -PQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDL 113
             +   VHRLD  TSGV+V+A    + R+L  QF++R+ KK Y   + G     EG +D 
Sbjct: 130 VNRPGIVHRLDKDTSGVMVIAKNDISHRKLVEQFKQRKTKKYYRTLLKGELPYKEGKIDA 189

Query: 114 PLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGH 173
           P+  D  +R K  V  +  K A T ++V+E+  D+ + V ++  TGR+HQ+RVH   +G 
Sbjct: 190 PIGRDPHDRKKMAVTRKNSKKAVTYFKVLEFFRDH-SYVEVELKTGRTHQIRVHFSYMGF 248

Query: 174 PILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
           P++GD  Y     R  A R LLHA  L   HP     + +KA  P DF
Sbjct: 249 PVVGDSIYGKKRNRLQATRQLLHAYRLGFYHPRNDKWVEYKASLPDDF 296


>UniRef50_Q82WZ5 Ribosomal large subunit pseudouridine synthase D n=2
           Tax=Nitrosomonas RepID=RLUD_NITEU
          Length = 344

 Score =  291 bits (746), Expect = 1e-77,   Method: Composition-based stats.
 Identities = 78/221 (35%), Positives = 122/221 (55%), Gaps = 15/221 (6%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR-----DYPQAESVHRLD 64
           +   L IL++DDH+++++KP+GL+  PG    H   +   +         P+A  VHRLD
Sbjct: 105 EAIPLKILFEDDHLIIIDKPAGLVVHPGNGNWHGTLLNALLNHAPQLSQVPRAGIVHRLD 164

Query: 65  MATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPK 124
             T+G++VVA T  A+ +L RQ ++R  K+ Y+A V G      G+VD P+     +R +
Sbjct: 165 KDTTGLLVVAKTIEAQFDLARQLQQRTVKRHYLALVLGKLEKD-GVVDAPIGRHPIHRTR 223

Query: 125 QKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYA-- 182
             V  + GKPA+T Y V+E    +T  +     TGR+HQ+RVH+L++GHP+ GD  Y   
Sbjct: 224 MAVV-QNGKPARTHYRVLEKFTAST-LLHCSLETGRTHQIRVHLLSIGHPLAGDPVYGRT 281

Query: 183 -----SPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
                + +A    PR  LHA  L +THP  G  + +++P  
Sbjct: 282 SPDPSTADAVVRLPRQALHAWQLELTHPHSGQILLWESPLP 322


>UniRef50_P59831 Ribosomal large subunit pseudouridine synthase A n=20
           Tax=Proteobacteria RepID=RLUA_HAEDU
          Length = 222

 Score =  291 bits (745), Expect = 2e-77,   Method: Composition-based stats.
 Identities = 135/222 (60%), Positives = 167/222 (75%), Gaps = 3/222 (1%)

Query: 1   MGMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESV 60
           M +  Y+PP  P+L  +Y+D+HI+V+NKPSGLLSVPG   E+ DSVMTR+Q+ Y  AE  
Sbjct: 1   MALIEYHPPLNPFLEEVYRDNHIVVINKPSGLLSVPGNRPEYYDSVMTRVQQRYGFAEPA 60

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSP---AEGLVDLPLIC 117
           HRLDMATSG+I++AL+K AE+ELKRQFR+REPKK Y+A +WG         G ++ PLIC
Sbjct: 61  HRLDMATSGIILLALSKVAEKELKRQFRDREPKKHYIALLWGKLGDRVGQTGEINFPLIC 120

Query: 118 DWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILG 177
           DW NRP+QK+CYE GK A T YEV+E+ A+NT RV   PITGRSHQLRVH LALGHPI+G
Sbjct: 121 DWENRPRQKICYERGKKATTHYEVLEHLANNTTRVKFTPITGRSHQLRVHSLALGHPIIG 180

Query: 178 DRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
           D+FYA+P A+++APRL LHAE LTI HP     MTF     F
Sbjct: 181 DKFYANPLAKSLAPRLCLHAESLTIAHPISAELMTFNTEPTF 222


>UniRef50_C7NAV5 Pseudouridine synthase n=5 Tax=Fusobacteriaceae RepID=C7NAV5_LEPBD
          Length = 326

 Score =  290 bits (743), Expect = 3e-77,   Method: Composition-based stats.
 Identities = 69/223 (30%), Positives = 107/223 (47%), Gaps = 16/223 (7%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYPQAESV 60
           P+   + I+Y+D+ + V+NK +G++  P         V   +             +   V
Sbjct: 94  PENIDIEIIYEDNDLAVINKKAGIVVHPANGHYSGTLVNAILYHIKDLSGINGEIRPGIV 153

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLD  TSG++++A    A  +L + F ++  KK Y+A + G  +   G +   +  D  
Sbjct: 154 HRLDKDTSGLLIIAKNDKAHLKLSQMFHDKTVKKIYLAILKGKLNQKSGRIVTQIGRDKN 213

Query: 121 NRPKQKVCYE--TGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGD 178
           +R K  V  +  +GK A T YEV+    +    V +   TGR+HQ+RVHM  LG+PILGD
Sbjct: 214 DRKKMTVINDLNSGKTAITNYEVISQ-TEKFTLVKVHIETGRTHQIRVHMKHLGYPILGD 272

Query: 179 RFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
             Y   +      R +LHA  L   HP    ++ F A  P DF
Sbjct: 273 SVYGRTDTE---KRQMLHAYKLEFQHPITEENLEFIAKLPEDF 312


>UniRef50_Q9JVB6 Ribosomal large subunit pseudouridine synthase D n=39
           Tax=Proteobacteria RepID=RLUD_NEIMA
          Length = 374

 Score =  289 bits (741), Expect = 5e-77,   Method: Composition-based stats.
 Identities = 77/225 (34%), Positives = 112/225 (49%), Gaps = 17/225 (7%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR-----DYPQAESVHRL 63
           P+   L I+Y+DD ++VVNKP+GL+  P         +   +         P+A  VHRL
Sbjct: 100 PEPMALDIVYEDDTVIVVNKPAGLVVHPAAGNWTGTLLNGLLAHCPELSQIPRAGIVHRL 159

Query: 64  DMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRP 123
           D  TSG++VVA T  A+  L  Q +ER  K+ Y A   G      G ++  +  D  NR 
Sbjct: 160 DKETSGLMVVAKTLPAQNSLVWQLQERTVKRIYRAVANGIVPFD-GKIETQIGRDPHNRL 218

Query: 124 KQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYAS 183
           K  V    GKPA T  +V+E    + + +     TGR+HQ+RVHM    HP+ GD  Y +
Sbjct: 219 KMAVVKFGGKPAVTHVKVLERYLAH-SYIECSLETGRTHQIRVHMREANHPLAGDPVYGN 277

Query: 184 PEA----------RAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           P            +++  R  LHA  L+ THP  G +++F+AP  
Sbjct: 278 PRHPCGDTVKEAVKSLGARQALHAYRLSFTHPESGETVSFEAPIP 322


>UniRef50_A7HM17 Pseudouridine synthase n=2 Tax=Thermotogaceae RepID=A7HM17_FERNB
          Length = 314

 Score =  289 bits (740), Expect = 7e-77,   Method: Composition-based stats.
 Identities = 79/224 (35%), Positives = 114/224 (50%), Gaps = 13/224 (5%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYPQAESV 60
           P++  L I+Y+D  I+V+NK  G+++ P         V   +             +   V
Sbjct: 74  PEDIPLDIIYEDRDILVINKQPGIITHPIPSHTSGTIVNGVLYHCKDLQGIGGVLRPGIV 133

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLD  TSGV+V+A    A + L +QF++R  +K Y+  V G P   EG +++ +  +  
Sbjct: 134 HRLDKDTSGVMVIAKNDLAHQSLTKQFKDRLTEKLYICLVKGVPKRKEGDIEINIARNPV 193

Query: 121 NRPKQKVC-YETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDR 179
            R K  V   E GKPA T Y+VV    D  A V   P TGR+HQ+RVHM  +GHP++GD 
Sbjct: 194 LRVKMTVTNSEYGKPALTHYKVVREFGDIAALVFAYPKTGRTHQIRVHMKYIGHPLMGDE 253

Query: 180 FYASPEARAM--APRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
            Y   +   +    R +LHA  L+  HP  G  + F A  P DF
Sbjct: 254 VYGRAKEDEIFGIKRQMLHALSLSFYHPRTGEKVKFIAKIPQDF 297


>UniRef50_A3EQJ0 Pseudouridine synthase n=1 Tax=Leptospirillum rubarum
           RepID=A3EQJ0_9BACT
          Length = 339

 Score =  288 bits (739), Expect = 7e-77,   Method: Composition-based stats.
 Identities = 77/235 (32%), Positives = 119/235 (50%), Gaps = 26/235 (11%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP------------- 55
           P+   L ILY+D+ ++V++KP GL+  P        +++  +   +              
Sbjct: 90  PENIRLEILYEDEDLIVISKPPGLVVHPAPGHSSG-TLVNGLLFHFQSQGDEQKKGEPEE 148

Query: 56  --------QAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPA 107
                   +A  VHRLD  TSGV+VV  T++   +L  QF++R   K+Y+A V G     
Sbjct: 149 EEEAERPLRAGLVHRLDQDTSGVMVVGKTESVVLDLMNQFKDRSVSKKYLALVKGILPKK 208

Query: 108 EGLVDLPLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVH 167
            G ++ P+     +R K  V  + GKP+ T Y V+E   +N + + +  +TGR+HQ+RVH
Sbjct: 209 RGEINAPIGRSTHDRKKFTV-RQDGKPSVTRYRVLETYHENYSLLEVTLLTGRTHQIRVH 267

Query: 168 MLALGHPILGDRFYASP-EARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
              LG P+LGD  Y S        PR +LHA  L+  HP+  + M F+A  P DF
Sbjct: 268 FRYLGFPLLGDAVYGSKGTENKNFPRQMLHAWKLSFQHPSSNSKMEFEAPLPPDF 322


>UniRef50_Q6AJM1 Pseudouridine synthase n=1 Tax=Desulfotalea psychrophila
           RepID=Q6AJM1_DESPS
          Length = 327

 Score =  287 bits (735), Expect = 2e-76,   Method: Composition-based stats.
 Identities = 78/225 (34%), Positives = 112/225 (49%), Gaps = 13/225 (5%)

Query: 8   PPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYPQAES 59
            PQ+     +Y+DD ++V++KP G++  PG        V   +          D  +   
Sbjct: 89  EPQQVDFESIYEDDSLLVLSKPPGIVVHPGNGNTEGTLVHGLLYHCREIGGVGDAIRPGI 148

Query: 60  VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDW 119
           VHRLD  TSG +VVA  + + R L   F+ER+  K Y A V G P   EG +  P+    
Sbjct: 149 VHRLDKDTSGAMVVAKDERSLRTLVDSFKERQVYKVYHALVCGIPKKYEGRIVAPIGRHS 208

Query: 120 PNRPKQKVCYETGKPAQTEYEVVEYAADN---TARVVLKPITGRSHQLRVHMLALGHPIL 176
            +R K  +   TGK A T ++VVE         + + +   TGR+HQ+RVHM ++G PI 
Sbjct: 209 VHRQKMAISERTGKFAATNWQVVEVFETKDGPYSLLRVHIETGRTHQIRVHMSSIGCPIA 268

Query: 177 GDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPA--DF 219
           GD+ Y S        R +LHA  L + HP  G +M+F AP   DF
Sbjct: 269 GDQVYGSKRQNPAFARQMLHASRLRLPHPVTGRTMSFTAPLWQDF 313


>UniRef50_C8NEP8 Pseudouridine synthase n=1 Tax=Granulicatella adiacens ATCC 49175
           RepID=C8NEP8_9LACT
          Length = 308

 Score =  287 bits (735), Expect = 2e-76,   Method: Composition-based stats.
 Identities = 73/223 (32%), Positives = 114/223 (51%), Gaps = 14/223 (6%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR----------DYPQAE 58
           P+   L I+++DD ++VVNKPSG++  P +       V   +            +  +  
Sbjct: 75  PENIPLDIVFEDDSLIVVNKPSGMVVHPSKGHYSGTLVNALLYHSNSLSDSTSEEIYRPG 134

Query: 59  SVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICD 118
            VHR+D  TSG++V+A      ++L  Q  E +  ++Y+A V GH +   G+VD PL   
Sbjct: 135 LVHRIDKDTSGLLVIAKNNDVHQKLAEQIAENKMNREYIAIVDGHFAHETGVVDAPLSRH 194

Query: 119 WPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGD 178
             NR K+ V  + GK A T +EV++  +D  + V  +  TGR+HQ+R HM  + HPI+ D
Sbjct: 195 QTNRLKR-VVEKGGKNAITHFEVLDSFSD-YSLVSCRLETGRTHQIRAHMEFIKHPIVND 252

Query: 179 RFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
             Y      A      LHA  L+ THP  G ++ F+   P +F
Sbjct: 253 PLYHPKGKNATEFGQFLHARTLSFTHPLTGETLNFQVEPPKEF 295


>UniRef50_Q45826 Uncharacterized RNA pseudouridine synthase Caur_0901 n=5
           Tax=Chloroflexi (class) RepID=Y901_CHLAA
          Length = 316

 Score =  286 bits (734), Expect = 3e-76,   Method: Composition-based stats.
 Identities = 72/216 (33%), Positives = 107/216 (49%), Gaps = 10/216 (4%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRD-------YPQAESVHR 62
           +   L ++Y+D  I V+NKP+G++  P         V   + R          +   VHR
Sbjct: 87  EPIPLDVVYEDADIAVINKPAGMVVHPAPGHPRGTLVNALLARYPDLAIGGELRPGIVHR 146

Query: 63  LDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNR 122
           LD  TSG++V+A    A R L  Q + R  +K Y A V G P P  G +D P+  D  +R
Sbjct: 147 LDRDTSGLLVIARHDQAMRSLVDQQQARRMRKIYQALVIGRP-PETGTIDAPIGRDPRDR 205

Query: 123 PKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYA 182
            +  V    G+PA+T Y +++   D  + + ++  TGR+HQ+RVH+  LG+PI+GD  Y 
Sbjct: 206 LRMAVV-PDGRPARTHYRLLDTFGD-YSLLEVQLETGRTHQIRVHLRHLGYPIVGDPVYG 263

Query: 183 SPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
              +     R  LHA  L + HP  G    F AP  
Sbjct: 264 PRRSHLHLSRQFLHAAYLGLVHPRSGRWQEFTAPLP 299


>UniRef50_Q2CAH0 Pseudouridine synthase n=3 Tax=Proteobacteria RepID=Q2CAH0_9RHOB
          Length = 215

 Score =  286 bits (733), Expect = 3e-76,   Method: Composition-based stats.
 Identities = 118/215 (54%), Positives = 148/215 (68%), Gaps = 3/215 (1%)

Query: 5   NYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLD 64
           +Y+PP +  L +L++D  +++V+KP+GLLSVPG+ E   D ++ R+Q  +P A  VHRLD
Sbjct: 4   DYDPP-DVPLAVLHEDHEVVLVDKPAGLLSVPGKGEHLADCLLARVQAAFPTALLVHRLD 62

Query: 65  MATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPK 124
             TSGV++ ALT  A+R L  QF +R+ +K YVARV G  +   G VDLPLI DWPNRPK
Sbjct: 63  RDTSGVMIFALTPHAQRHLGLQFEKRQTRKTYVARVAGRIADKTGTVDLPLIVDWPNRPK 122

Query: 125 QKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASP 184
           Q V +E GKPA T++ VV  A+D   RV L P TGRSHQLRVHMLALGHPILGD FYA  
Sbjct: 123 QMVDHENGKPAVTDWRVV-RASDAETRVRLFPKTGRSHQLRVHMLALGHPILGDPFYAEG 181

Query: 185 EARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
            ARA  PR++LH+E L   HP  G  M   APA F
Sbjct: 182 PARAH-PRMMLHSETLQFRHPDGGRGMRITAPAPF 215


>UniRef50_B1I3F8 Pseudouridine synthase n=2 Tax=Bacteria RepID=B1I3F8_DESAP
          Length = 309

 Score =  285 bits (732), Expect = 6e-76,   Method: Composition-based stats.
 Identities = 71/219 (32%), Positives = 102/219 (46%), Gaps = 9/219 (4%)

Query: 8   PPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYPQAES 59
            P+   L + ++D  ++VVNKP GL+  P         V   +             +   
Sbjct: 75  EPEAIPLEVCFEDPDVLVVNKPRGLVVHPAVGHYSGTLVNALLHHCRDLSGINGILRPGI 134

Query: 60  VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDW 119
           VHRLD  TSG+++VA   AA   L  Q ++R   ++Y A V G P    G VD P+    
Sbjct: 135 VHRLDRDTSGLLMVAKNDAAHLALAGQLKDRAVLRRYTALVHGRPRRETGTVDAPIGRHP 194

Query: 120 PNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDR 179
            +R +  V   +G+ A+T Y VV    D  + + L   TGR+HQ+RVHM  +GHP++GD 
Sbjct: 195 RDRQRMAVTPRSGRAARTHYRVVRRF-DKFSLLELTLDTGRTHQIRVHMAHVGHPLVGDL 253

Query: 180 FYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
            Y             LHA  L   HP  G  + F+AP  
Sbjct: 254 KYGHARPELGLEGQFLHAGTLGFRHPRTGEVLVFEAPLP 292


>UniRef50_Q2W2D5 Pseudouridine synthase n=39 Tax=Bacteria RepID=Q2W2D5_MAGSA
          Length = 505

 Score =  285 bits (731), Expect = 6e-76,   Method: Composition-based stats.
 Identities = 76/236 (32%), Positives = 115/236 (48%), Gaps = 25/236 (10%)

Query: 8   PPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR---------DYPQAE 58
            PQ+  L ++Y+D+ ++V++KP+G++  P      +  V   +              +  
Sbjct: 259 EPQDIALTVVYEDEDLIVIDKPAGMVVHPAPGNPDETLVNALLAHCGESLAGIGGVKRPG 318

Query: 59  SVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICD 118
            VHR+D  TSG++V A T AA R L  QF     ++ Y A VWG PSP +G ++  +  +
Sbjct: 319 IVHRIDKDTSGLLVAAKTDAAHRGLATQFAAHTLERAYWALVWGTPSPRQGEIEGNIGRN 378

Query: 119 WPNRPKQKVCYETGKPAQTEYEVVEYAADNT-ARVVLKPITGRSHQLRVHMLALGHPILG 177
             +R K  V    GKPA T Y V++  A    + V  +  TGR+HQ+RVHM   GHP++G
Sbjct: 379 PNDRKKMAVVKSGGKPALTRYRVLKSFAGGAVSLVECRLATGRTHQIRVHMTTQGHPLVG 438

Query: 178 DRFYAS-------------PEARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PAD 218
           D  Y                 A    PR  LHA +L  +HP  G  + F++  P D
Sbjct: 439 DPVYGRIRGHKGVVLPPEVKTALIQFPRQALHAYLLGFSHPTKGYDVRFESGMPLD 494


>UniRef50_B6AN83 Pseudouridine synthase n=2 Tax=Leptospirillum RepID=B6AN83_9BACT
          Length = 340

 Score =  284 bits (729), Expect = 1e-75,   Method: Composition-based stats.
 Identities = 77/235 (32%), Positives = 116/235 (49%), Gaps = 26/235 (11%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP------------- 55
           P++  L ILY+DD ++V++KP GL+  P        +++  +   +              
Sbjct: 90  PEDIHLEILYEDDDLIVISKPPGLVVHPAPGHASG-TLVNGLLFHFQSQGDEQKKGEPEE 148

Query: 56  --------QAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPA 107
                   +A  VHRLD  TSGV+VV  ++    +L  QF++R   K+Y+A V G     
Sbjct: 149 EEEAERPLRAGLVHRLDQDTSGVMVVGKSETVVLDLMNQFKDRSVSKKYLALVKGILPKK 208

Query: 108 EGLVDLPLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVH 167
            G ++ P+     +R K  V  + GKP+ T Y V+E   +N + + +  +TGR+HQ+RVH
Sbjct: 209 RGEINAPIGRSTHDRKKFAV-RQDGKPSLTRYRVLETYHENYSLLEVTLLTGRTHQIRVH 267

Query: 168 MLALGHPILGDRFYASP-EARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
              LG P+LGD  Y S        PR +LHA  L   HP     M F+A  P DF
Sbjct: 268 FRHLGFPLLGDAVYGSKGMENRNFPRQMLHAWKLAFQHPRSAAKMEFEAPLPPDF 322


>UniRef50_C8QZ10 Pseudouridine synthase n=1 Tax=Desulfurivibrio alkaliphilus AHT2
           RepID=C8QZ10_9DELT
          Length = 324

 Score =  284 bits (729), Expect = 1e-75,   Method: Composition-based stats.
 Identities = 78/219 (35%), Positives = 103/219 (47%), Gaps = 11/219 (5%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYPQAESVH 61
           +E     LY+D+ I+V+ KP GL+  P         V   +             +   VH
Sbjct: 89  EEVEFTPLYEDEDILVLVKPPGLVVHPADGHRQGTLVHGLLHHCRNLSGISGQLRPGIVH 148

Query: 62  RLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPN 121
           RLD  TSG +VVA    A   L +QF+ RE +K Y A + G  +   G V LP+     +
Sbjct: 149 RLDKDTSGCLVVAKNDLAHHNLVQQFKGREVEKTYQALLRGILAEDTGQVVLPIGRHPVH 208

Query: 122 RPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFY 181
           R K  V  E G+ A T + V +  +     V L   TGR+HQ+RVHM ALGHP+ GDR Y
Sbjct: 209 RKKMAVRREGGREAVTHWRVRQRFSAGYTLVELLLETGRTHQIRVHMAALGHPLAGDRLY 268

Query: 182 ASPEARAM---APRLLLHAEMLTITHPAYGNSMTFKAPA 217
                + M     R  LHA  L   HP  G  +TF AP 
Sbjct: 269 GRNPEKDMPYGIDRQWLHAWRLAFNHPRSGRRLTFTAPL 307


>UniRef50_C6XFD0 Pseudouridine synthase n=1 Tax=Candidatus Liberibacter asiaticus
           str. psy62 RepID=C6XFD0_LIBAP
          Length = 340

 Score =  284 bits (728), Expect = 2e-75,   Method: Composition-based stats.
 Identities = 75/242 (30%), Positives = 107/242 (44%), Gaps = 33/242 (13%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR---------DYPQAESV 60
           +   L ILY+DD I+V+NKP+GL+  P         V   +              +   V
Sbjct: 86  ENIPLDILYEDDDIIVINKPAGLVVHPAPGNWTGTLVNALLYHCHNNLSSINGVKRPGIV 145

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFRER----EPKKQYVARVWGHPSPAEGLVDLPLI 116
           HRLD  T+GV+VVA    A ++L  QF +       K+ Y A VWG P P  G+++ PL 
Sbjct: 146 HRLDKDTTGVMVVAKNDLAHQKLSEQFVDHGKSTRLKRAYYAMVWGIPLPDSGIINAPLG 205

Query: 117 CDWPNRPKQKV---CYETGKPAQTEYEVVEYAADN----TARVVLKPITGRSHQLRVHML 169
               NR ++ V     +T   A T Y+ +E    N     + +     TGR+HQ+RVHM 
Sbjct: 206 RCKSNRLRRAVKGIDDKTADSAITHYQTIEIYNKNSNFAVSLLKCHLETGRTHQIRVHMA 265

Query: 170 ALGHPILGDRFYAS-------------PEARAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
             G+P++GD  Y                 A     R  LHA  L+ +HP     M F+ P
Sbjct: 266 HKGNPLIGDPLYGKGFKTKANIVNNNAKSAILSLARQALHAHSLSFSHPRNNQDMDFQVP 325

Query: 217 AD 218
             
Sbjct: 326 IP 327


>UniRef50_D1PCC3 Pseudouridine synthase n=1 Tax=Prevotella copri DSM 18205
           RepID=D1PCC3_9BACT
          Length = 387

 Score =  284 bits (727), Expect = 2e-75,   Method: Composition-based stats.
 Identities = 79/246 (32%), Positives = 112/246 (45%), Gaps = 31/246 (12%)

Query: 4   ENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMT---------RIQRDY 54
           E    P+E  + ++Y+DD +MVVNK +G++  PG    H   +               + 
Sbjct: 121 ETSIKPEEIAINVVYEDDQLMVVNKEAGMVVHPGAGNFHGTLIQAVAWHLRDMPEFDAND 180

Query: 55  PQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLP 114
           P+   VHR+D  TSG++VVA T  A+  L +QF  +   + Y A VWG+    EG ++  
Sbjct: 181 PEVGLVHRIDKDTSGLLVVAKTPTAKNALGKQFFNKTTHRSYNALVWGNIVEDEGRIEGN 240

Query: 115 LICDWPNRPKQKVCYET---GKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLAL 171
           +  D  NR + KV       GK A T Y+V+E     T  V     TGR+HQ+R HM  +
Sbjct: 241 IGRDPKNRLRMKVFDPDSGIGKTAVTHYKVLERFG-YTTLVQCVLETGRTHQIRAHMKHI 299

Query: 172 GHPILGDRFYASPEAR----------------AMAPRLLLHAEMLTITHPAYGNSMTFKA 215
           GHP+  D  Y   E                   + PR  LHA+ L   HP     M F +
Sbjct: 300 GHPLFMDETYGGTEILRGQRSSSYKAFIQNCFKLCPRQALHAKTLGFVHPTTKQQMDFDS 359

Query: 216 --PADF 219
             P DF
Sbjct: 360 EWPNDF 365


>UniRef50_C9LM35 Pseudouridine synthase n=1 Tax=Dialister invisus DSM 15470
           RepID=C9LM35_9FIRM
          Length = 308

 Score =  283 bits (726), Expect = 2e-75,   Method: Composition-based stats.
 Identities = 70/218 (32%), Positives = 108/218 (49%), Gaps = 10/218 (4%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRI---------QRDYPQAESV 60
           Q   L ILY+D+ ++V+NK  G++  PG        V   +           D  +   V
Sbjct: 76  QNIPLDILYEDNDMIVINKRRGVVVHPGAGNTEGTLVNALLFHCGEQLRSVGDPERPGIV 135

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLD  TSGV+V A ++ A   L+++    + ++ Y+A V G      G++ LPL     
Sbjct: 136 HRLDKDTSGVMVAAKSERAYGILQKEIASHKAQRCYIALVHGQMEGDTGVIRLPLGRSTK 195

Query: 121 NRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRF 180
           +R K  V +ETG+PA T + V+EY   + + +  K  TGR+HQ+RVHM  + H ++ D  
Sbjct: 196 DRMKWDVLHETGRPAVTHFHVIEYLP-HYSWIECKLETGRTHQIRVHMAHIRHAVVNDPL 254

Query: 181 YASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           Y   +         LH+  L + HP  G  M F+AP  
Sbjct: 255 YGWKKDHFPIKGQALHSHTLELCHPITGEVMHFEAPVP 292


>UniRef50_Q489H0 Pseudouridine synthase n=3 Tax=Gammaproteobacteria
           RepID=Q489H0_COLP3
          Length = 567

 Score =  283 bits (725), Expect = 3e-75,   Method: Composition-based stats.
 Identities = 101/220 (45%), Positives = 142/220 (64%), Gaps = 14/220 (6%)

Query: 6   YNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAE---SVHR 62
            NP +   L I++QD+H++VVNKP+GLLSVPG+    KDSV TRI+  +PQA     VHR
Sbjct: 356 INPAEGIDLEIVFQDEHVVVVNKPAGLLSVPGK--SIKDSVYTRIKTQFPQASGGLIVHR 413

Query: 63  LDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNR 122
           LDMATSG++++AL + A + L++QF  +E  K+YVA + G      G + LPL  D+ +R
Sbjct: 414 LDMATSGLLMLALNERAHKHLQQQFMNKEINKRYVATIEGKLEKTSGEICLPLRGDFDDR 473

Query: 123 PKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLA---LGHPILGDR 179
           PKQ VC+E GK A+T ++++E   DNT+++ L PITGR+HQLR+H      L  PI+GD 
Sbjct: 474 PKQMVCHEHGKYAETHWQLIEEV-DNTSKLFLYPITGRTHQLRMHCAHPDGLNLPIIGDS 532

Query: 180 FYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
            Y        A RL LHA+ L+ THP     +TF+   +F
Sbjct: 533 LYGHS-----ADRLHLHAQRLSFTHPITKELLTFEVAENF 567


>UniRef50_P50513 Ribosomal large subunit pseudouridine synthase D n=8
           Tax=Sphingomonadales RepID=RLUD_ZYMMO
          Length = 317

 Score =  283 bits (725), Expect = 4e-75,   Method: Composition-based stats.
 Identities = 79/233 (33%), Positives = 113/233 (48%), Gaps = 21/233 (9%)

Query: 6   YNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR---------DYPQ 56
           +N PQ+  L I+++D+H++VVNKP+G++  P         V   +              +
Sbjct: 74  HNEPQDIPLEIVFEDEHLLVVNKPAGMVVHPAAGNYDNTLVNALLYHCAGKLSGIGGVAR 133

Query: 57  AESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLI 116
              VHR+D  TSG++VVA T  A   L  QF +    ++Y A V GHPS  +G VD PL 
Sbjct: 134 PGIVHRIDKDTSGLLVVAKTDPAHAGLAAQFADHSINRRYRAIVDGHPS-LQGHVDAPLA 192

Query: 117 CDWPNRPKQKVCYET-GKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPI 175
               NR K  +  +  GK A T Y ++     N + +  +  TGR+HQ+RVHM ++GH +
Sbjct: 193 RSSVNRQKMAIVSDGRGKRAVTHYRMI-TPLKNASLIECRLETGRTHQVRVHMSSIGHSL 251

Query: 176 LGDRFYASPEARAMA-------PRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
           LGD  Y   +    A        R  LHA  L   HP  G  + F A  P D 
Sbjct: 252 LGDPVYGRSKKAHHALLQSLAFQRQALHAAHLGFIHPISGKQVDFDAEMPQDM 304


>UniRef50_C0BNA6 Pseudouridine synthase n=7 Tax=Bacteroidetes RepID=C0BNA6_9BACT
          Length = 379

 Score =  282 bits (724), Expect = 4e-75,   Method: Composition-based stats.
 Identities = 75/240 (31%), Positives = 110/240 (45%), Gaps = 26/240 (10%)

Query: 4   ENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRI--QRDYP-----Q 56
           E    P++  L ++Y+D  +MVVNKP G++  PG        +   +   +D P     +
Sbjct: 122 EFLLTPEDIPLDVVYEDSDLMVVNKPPGMVVHPGHGNYSGTLINALLFHVKDLPLNADER 181

Query: 57  AESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLI 116
              VHR+D  TSG++VVA T  A   L +QF ++  +++YVA VWG+    +G V   + 
Sbjct: 182 PGLVHRIDKDTSGLLVVAKTAKAMTHLAKQFFDKTSEREYVAIVWGNVEEEQGTVRGHIG 241

Query: 117 CDWPNRPKQKV--CYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHP 174
               NR +  V    + GK A T Y+V+E        V     TGR+HQ+R HM  +GH 
Sbjct: 242 RHPKNRLQMAVFPDGDQGKEAVTHYKVMERLG-YVTLVSCVLETGRTHQIRAHMKHIGHT 300

Query: 175 ILGDRFYASPE----------------ARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           +  D  Y   +                A    PR  LHA+ L   HP+ G  M F  P  
Sbjct: 301 LFNDERYGGEKILKGTTFTKYKQFVDNAFKALPRQALHAKTLGFVHPSSGELMRFNTPIP 360


>UniRef50_B9L028 Pseudouridine synthase n=2 Tax=Thermomicrobia (class)
           RepID=B9L028_THERP
          Length = 322

 Score =  282 bits (724), Expect = 5e-75,   Method: Composition-based stats.
 Identities = 78/234 (33%), Positives = 115/234 (49%), Gaps = 21/234 (8%)

Query: 3   MENYNPPQEPW---------LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRD 53
           +E Y PP EP          + ++Y+DD I+V +KP G+++ P    EH  +++  ++  
Sbjct: 68  LEVYLPPVEPPTDLEPEFLPIPVIYEDDDIIVFDKPPGIVTHPAPGHEHG-TLVNALKAI 126

Query: 54  YP--------QAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPS 105
            P        +   VHRLD  TSG++VVA T+AA   L  Q++ R   K+Y A V G   
Sbjct: 127 RPDLQVQPSHRPGIVHRLDKDTSGLLVVAKTEAARLALLEQWQSRSVVKKYTALVHGVVE 186

Query: 106 PAEGLVDLPLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLR 165
           P  G +D P+  D   R K  V    G+PA T + V+E        + +   TGR+HQ+R
Sbjct: 187 PDSGTIDAPISRDPVERTKMAVV-SWGRPAITHFRVLERFR-CATLLDVTIETGRTHQIR 244

Query: 166 VHMLALGHPILGDRFYAS-PEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           VH   +GHP++GD  Y          PR  LHA  L   HP  G ++  + P  
Sbjct: 245 VHCAFIGHPVVGDSQYGGHRPFCVPVPRQFLHARYLRFVHPTTGQAIELETPLP 298


>UniRef50_B2A2J2 Pseudouridine synthase n=1 Tax=Natranaerobius thermophilus
           JW/NM-WN-LF RepID=B2A2J2_NATTJ
          Length = 328

 Score =  282 bits (722), Expect = 7e-75,   Method: Composition-based stats.
 Identities = 71/226 (31%), Positives = 113/226 (50%), Gaps = 18/226 (7%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRD---------YPQAES 59
           PQ   L I+Y+D++++VVNKP  ++  PG    ++D+++  +            Y +   
Sbjct: 86  PQSIPLDIVYEDEYLLVVNKPRNMVVHPGAG-NYRDTMVNALLYHCQNLSDGTSYERPGI 144

Query: 60  VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDW 119
           VHRLD  TSG++VVA        L  + + R   + Y+A V G  S  +  +DLP+  D 
Sbjct: 145 VHRLDKDTSGLLVVAKQNETHDILSEEIKNRRVARTYLALVIGDFSKKKATIDLPIGRDP 204

Query: 120 PNRPKQKVCYETGKPAQTEYEVVEYA--ADNTARVVLKPITGRSHQLRVHMLALGHPILG 177
            NR K  V +  GK A T+ E++      +  + +     TGR+HQ+RVH+  LG+P+LG
Sbjct: 205 RNRKKMAVVH-GGKRAITKVEMLRSFQNPEKISYLKCSLETGRTHQIRVHLSHLGYPLLG 263

Query: 178 DRFYASPEARAM-----APRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           D  Y     + +          LH+  L  THP +  +M F+AP  
Sbjct: 264 DPVYRGKTGKNVDIDKNLTGQALHSFSLAFTHPVFKKTMVFRAPLP 309


>UniRef50_Q1MQ60 Pseudouridylate synthases, 23S RNA-specific n=1 Tax=Lawsonia
           intracellularis PHE/MN1-00 RepID=Q1MQ60_LAWIP
          Length = 541

 Score =  282 bits (722), Expect = 8e-75,   Method: Composition-based stats.
 Identities = 77/221 (34%), Positives = 120/221 (54%), Gaps = 14/221 (6%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP--------QAESV 60
           P+E +L IL+ D+H+ ++NKP GL   P      + +++ R+ + +P        +   V
Sbjct: 78  PEEGFLEILFSDEHLAIINKPPGLTVHPAP-SCQESTLVHRLLKYFPKLIEQGGLRPGIV 136

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HR+D  TSG++ +ALT+    +L + F +R+  K+Y+A V G PS  EG + +PL  D  
Sbjct: 137 HRIDKDTSGLLCIALTEDTRLKLSKIFLDRKINKEYLALVHGVPS-MEGYIAVPLGRDPK 195

Query: 121 NRPKQKVCYETGKPAQTEYEVVEYAADN-TARVVLKPITGRSHQLRVHMLALGHPILGDR 179
            + K  V    GKPA TE+ V+    ++  + + L   TGR+HQ+RVHM  +GHP++GD+
Sbjct: 196 TKVKVAV-NPKGKPAHTEWRVLHRGKNDVYSILALTIQTGRTHQIRVHMKHIGHPLVGDK 254

Query: 180 FYASPEARAM--APRLLLHAEMLTITHPAYGNSMTFKAPAD 218
            YA           R +LHA  L+  HP  G  M F  P  
Sbjct: 255 LYAGGHVNKTFQCNRQMLHAWKLSFEHPITGKKMNFLCPPP 295


>UniRef50_C6BSG2 Pseudouridine synthase, RluA family n=1 Tax=Desulfovibrio
           salexigens DSM 2638 RepID=C6BSG2_DESAD
          Length = 549

 Score =  280 bits (719), Expect = 2e-74,   Method: Composition-based stats.
 Identities = 81/232 (34%), Positives = 120/232 (51%), Gaps = 22/232 (9%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP--------QAESV 60
           P+E  L I+Y D  I V+NKP+GL + P        +++ R+   +P        +   V
Sbjct: 89  PEELPLEIIYNDGKIAVINKPAGLTTHPAPSCPTG-TLVHRMIHHFPEIRDMDEWRPGIV 147

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLD  TSG+I VAL +     +   F +RE  K Y+A V G P    G +D P+     
Sbjct: 148 HRLDKFTSGLITVALNEHDRLAMSTAFADREVNKAYLAIVHGVPKREFGEIDQPMGRHPV 207

Query: 121 NRPKQKVCYETGKPAQTEYEVVEY-AADNTARVVLKPITGRSHQLRVHMLALGHPILGDR 179
           ++ K  V  + G+ A++EYEV+    A   + V +K  TGR+HQ+RVHM  +GHP++GD+
Sbjct: 208 HKTKMAVVLKGGRDARSEYEVLWSDPAGRASLVKVKIYTGRTHQIRVHMAHIGHPLVGDQ 267

Query: 180 FYAS----------PEARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
            Y S          P+   +A R +LHA  L+ THP     ++F    P DF
Sbjct: 268 VYGSMPHAIWEQDQPQLAKLAERQMLHAYSLSFTHPDSEEELSFTQAPPEDF 319


>UniRef50_Q2SS88 Pseudouridine synthase n=4 Tax=Mollicutes RepID=Q2SS88_MYCCT
          Length = 322

 Score =  280 bits (718), Expect = 2e-74,   Method: Composition-based stats.
 Identities = 66/222 (29%), Positives = 101/222 (45%), Gaps = 9/222 (4%)

Query: 5   NYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP--------Q 56
           N    ++  L I+YQDD ++V+NK + +   P     +   V   +  D          +
Sbjct: 86  NITKNKDIDLNIIYQDDDLLVINKQNNITVHPSLNNTNNTIVNALLASDVELSSINGELR 145

Query: 57  AESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLI 116
              VHR+D  T+G+++VA      + L   F+  +  K+Y+A V G   P +GL+D P+ 
Sbjct: 146 PGIVHRIDKQTTGLLIVAKNDKTHKLLSEMFKNHQIYKEYLAIVTGVIKPNKGLIDAPIG 205

Query: 117 CDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPIL 176
               +R K  V  +  K A T +EVVE    NT  +  +  TGR+HQ+RVH   + HP+L
Sbjct: 206 RSQTDRKKMSVTAKNSKHAITTFEVVERFLKNT-LIKCQIQTGRTHQIRVHFNYINHPVL 264

Query: 177 GDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
            D  Y             LHA  L  THP     +   +P  
Sbjct: 265 NDPIYGKKHQEFTDFGQYLHAYKLKFTHPITKKEIELISPLP 306


>UniRef50_A6LDZ7 Pseudouridine synthase n=26 Tax=Bacteroidales RepID=A6LDZ7_PARD8
          Length = 549

 Score =  280 bits (718), Expect = 2e-74,   Method: Composition-based stats.
 Identities = 97/215 (45%), Positives = 127/215 (59%), Gaps = 15/215 (6%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAE---SVHRLDMA 66
           +E  L ILY+DD+++V+NKP G+LSVPG+ +   DSV  R+   YP+A     VHRLDMA
Sbjct: 336 RETKLDILYEDDYLLVINKPEGMLSVPGKGD--ADSVYQRLSILYPEATGPIIVHRLDMA 393

Query: 67  TSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQK 126
           TSG+++ A TK A + L+ QF+ R  +K+Y+A + G     EG + LPL  D  +RP+Q 
Sbjct: 394 TSGLLLAAKTKEAHQNLQAQFKNRTIQKRYIALLEGEVPQDEGEIRLPLCPDPLDRPRQI 453

Query: 127 VCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLA---LGHPILGDRFYAS 183
           V  E GKPA T Y V+E  +  T  +   P TGR+HQLRVH      L  PILGD  Y  
Sbjct: 454 VSEEFGKPALTHYRVLERTSGKT-LIAFYPQTGRTHQLRVHAAHPLGLHCPILGDELYGR 512

Query: 184 PEARAMAPRLLLHAEMLTITHPAYGNSMTF-KAPA 217
                 A RL LHAE L  THP     +   K+PA
Sbjct: 513 K-----AERLYLHAEYLAFTHPITSERIEIQKSPA 542


>UniRef50_D2BIX0 Pseudouridine synthase n=5 Tax=Dehalococcoides RepID=D2BIX0_DEHSV
          Length = 302

 Score =  280 bits (717), Expect = 3e-74,   Method: Composition-based stats.
 Identities = 74/218 (33%), Positives = 112/218 (51%), Gaps = 14/218 (6%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP---------QAESV 60
           ++  L I++QD  ++++NKP GL   P        +++  +    P         +   V
Sbjct: 76  EDIPLEIIFQDKDLLLINKPPGLTVHPAPGHPDH-TLINGVLALEPKMEDFDDPLRPGIV 134

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLD  TSG+++VA  +     L  QF+ER  +K Y+  V G   PAEG ++ PL  D  
Sbjct: 135 HRLDKDTSGLLLVAKNRETLANLSAQFKERTVRKYYLTLVKGELHPAEGFIEAPLGRDPQ 194

Query: 121 NRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRF 180
           NR K  V    G+ A+T Y+V+ Y     + + +K  TGR+HQ+RVH  A+GHP+ GD  
Sbjct: 195 NRQKIAVV-SNGRHARTGYKVLRYI-QGYSLLEVKLETGRTHQIRVHFAAIGHPVAGDAI 252

Query: 181 YASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           Y   E      R  LHA  L+ T P+ G ++ F +P  
Sbjct: 253 YGQKET--WLKRQFLHAHRLSFTLPSNGQTVEFTSPLP 288


>UniRef50_A0L9J0 Pseudouridine synthase n=1 Tax=Magnetococcus sp. MC-1
           RepID=A0L9J0_MAGSM
          Length = 332

 Score =  279 bits (716), Expect = 4e-74,   Method: Composition-based stats.
 Identities = 76/237 (32%), Positives = 114/237 (48%), Gaps = 28/237 (11%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR---------------D 53
           P+E  L IL++D+H++V+NKP+G++  PG    H   V   +                  
Sbjct: 82  PEEIALEILFEDEHLIVLNKPAGMVVHPGAGVNHGTLVNALLYHCGTPDNPHGGLSGIGG 141

Query: 54  YPQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDL 113
             +   VHRLD  TSG++V A    A   L RQF +R   ++Y+A   G P PA+G ++ 
Sbjct: 142 VIRPGIVHRLDKETSGIMVAAKQDHAHIHLSRQFEQRTIGRRYLALTRGIPQPAQGRIEG 201

Query: 114 PLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGH 173
            +     +R K  V  + G+ A T Y+V+E      A +  +  +GR+HQ+RVHM  +GH
Sbjct: 202 AIGRHPIHRTKMAVVEQGGRAAATRYKVLEPLGQ-FALIRCRLESGRTHQIRVHMTHIGH 260

Query: 174 PILGDRFYAS------------PEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           P++GD  Y +             +      R  LHA  LT  HP  G  M+FK P  
Sbjct: 261 PLVGDPLYGAQHKAPSHWPPLHRQRFDQFQRQALHAHTLTFIHPHTGEEMSFKRPPP 317


>UniRef50_C4FWV7 Pseudouridine synthase n=2 Tax=Firmicutes RepID=C4FWV7_9FIRM
          Length = 309

 Score =  279 bits (714), Expect = 7e-74,   Method: Composition-based stats.
 Identities = 75/233 (32%), Positives = 116/233 (49%), Gaps = 17/233 (7%)

Query: 1   MGMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR-------- 52
           +  ++   P+   L I+Y+D+ I+V+NKP+GL+  P +       V   +          
Sbjct: 68  VEEDSLPEPEAMDLDIIYEDEDILVINKPAGLVVHPSKGHLKGTLVNGLLHYLNGNLSTG 127

Query: 53  -DYPQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLV 111
            D+ +   VHR+D  TSG++VVA   AA + L  Q    + ++ Y+A V G     +G +
Sbjct: 128 SDFYRPGIVHRIDKDTSGLLVVAKHNAAHQALADQLLNHDMRRSYIALVHGQVKAPQGTI 187

Query: 112 DLPLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLAL 171
           + PL  D  NR +  V  E GK A T ++V+E   +N   + L+  TGR+HQ+RVH+  +
Sbjct: 188 EAPLQRDPANRLRWTVAKE-GKYALTRFQVMENF-ENATLLDLELETGRTHQIRVHLEFI 245

Query: 172 GHPILGDRFYASPEARAMAP------RLLLHAEMLTITHPAYGNSMTFKAPAD 218
           GHP++GD  Y                  LLHA  L + HP  G  + FKAP  
Sbjct: 246 GHPLVGDPVYRKGLDHIKGSLVHDMTGQLLHAYALKLQHPRSGEWLEFKAPLP 298


>UniRef50_A9NGF1 Pseudouridine synthase n=1 Tax=Acholeplasma laidlawii PG-8A
           RepID=A9NGF1_ACHLI
          Length = 297

 Score =  278 bits (713), Expect = 8e-74,   Method: Composition-based stats.
 Identities = 76/226 (33%), Positives = 112/226 (49%), Gaps = 12/226 (5%)

Query: 2   GMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------- 52
              N   P+   L I+Y+DD IMV+NKP GL+  P         V   +           
Sbjct: 64  EETNPLKPKNIDLNIVYEDDDIMVINKPKGLVVHPSETFSETTLVSGLLHHTDTLSTHND 123

Query: 53  DYPQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVD 112
           D  +   +HR+D  TSG+I+VA T  A + L +  +  + K++Y+A V G     +G++D
Sbjct: 124 DPLRPGILHRIDKDTSGLILVAKTNEAHKILAQDLKSHDIKREYIALVEGVLDHNKGVID 183

Query: 113 LPLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALG 172
            P+      R K  V   TGKPA T +EV+    D+T  +  K  TGR+HQ+RVH+  + 
Sbjct: 184 APIARHPKIRTKMAVV-ATGKPAITHFEVMRTFRDHT-LLHCKLETGRTHQIRVHLAYIK 241

Query: 173 HPILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           HP+ GD  Y + +A+ +    LLHA  L   HP     M  +AP  
Sbjct: 242 HPVTGDPLYGT-KAKILKDGQLLHAFRLEFVHPITKKVMMLEAPLP 286


>UniRef50_B8E0R4 Pseudouridine synthase n=1 Tax=Dictyoglomus turgidum DSM 6724
           RepID=B8E0R4_DICTD
          Length = 303

 Score =  278 bits (713), Expect = 8e-74,   Method: Composition-based stats.
 Identities = 63/227 (27%), Positives = 109/227 (48%), Gaps = 12/227 (5%)

Query: 3   MENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DY 54
           +E    PQ+  + I+Y+D+ ++++NKP G++  P     +   V   + R          
Sbjct: 68  VETEVKPQDIPIEIVYEDEDMVIINKPKGMVVHPAHGHYNDTLVNALLYRVKDLSGIGGE 127

Query: 55  PQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLP 114
            +   +HRLD  T+G++++A    + ++L  Q + R  ++ Y A   G     E  ++ P
Sbjct: 128 LRPGIIHRLDKDTTGLLIIAKNDLSHQKLSEQLKNRTLRRTYWALCEGEIPWEEKRIEAP 187

Query: 115 LICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHP 174
           +     NR K  +    GK A T ++V+E        +     TGR+HQ+RVH+  LG P
Sbjct: 188 IGRHPINRKKMAIV-PYGKIAITNFKVLERFK-GYTLISADLETGRTHQIRVHISHLGFP 245

Query: 175 ILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFK--APADF 219
           I+GD  Y   + +      LLHA+ ++  HP  G  M F+   P +F
Sbjct: 246 IVGDEVYGRIDKKFGVKGQLLHAKKVSFIHPTKGIPMEFEIDLPEEF 292


>UniRef50_A7NB61 Pseudouridine synthase n=18 Tax=Francisella RepID=A7NB61_FRATF
          Length = 332

 Score =  278 bits (712), Expect = 1e-73,   Method: Composition-based stats.
 Identities = 71/223 (31%), Positives = 111/223 (49%), Gaps = 16/223 (7%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRD-----YPQAESVHRLD 64
           ++  L I+++DD I+V++KP  ++  PG            + R       P+A  VHRLD
Sbjct: 84  EDINLKIIFEDDDIIVIDKPVNMIVHPGAGNPTGTVSNALLHRYKDQDKLPRAGIVHRLD 143

Query: 65  MATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPK 124
             TSG++V A +  A   L +Q  ER+  ++Y+A V G     +G ++ P+  D  NR K
Sbjct: 144 KDTSGLMVAAKSSIAYHNLVQQLAERKVSRKYLAIVEGEIYQ-QGTINQPIGRDPTNRTK 202

Query: 125 QKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASP 184
             + Y  GK A T Y  +E   D    +  +  TGR+HQ+RVHM ++ HP++GD+ Y   
Sbjct: 203 MAINYR-GKEAITYYTPIE-VYDGFTLIECQLETGRTHQIRVHMKSIKHPLVGDQTYNKS 260

Query: 185 EAR------AMAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
             +       +  R  LHA  L+  HP     + FK+  P D 
Sbjct: 261 STKLEKLAITIPTRQALHAYKLSFIHPTTAKMVKFKSKLPEDM 303


>UniRef50_D1ANU4 Pseudouridine synthase n=14 Tax=Fusobacteriaceae RepID=D1ANU4_SEBTE
          Length = 305

 Score =  278 bits (712), Expect = 1e-73,   Method: Composition-based stats.
 Identities = 67/221 (30%), Positives = 104/221 (47%), Gaps = 13/221 (5%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYPQAESV 60
           P+   + ILY+D  I V++K +G++  P    E    V   +             +   V
Sbjct: 72  PENINIKILYEDSDIAVIDKEAGIVVHPSHGHESGTLVNAVMYHIKDLSGINGEIRPGIV 131

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLD  TSG++++A    A   L   F     +K Y+A + G  +   G ++  +  D  
Sbjct: 132 HRLDKDTSGLLIIAKNDTAHLRLSEMFGSSGIRKTYIAILKGKINKESGKLETLIGRDPK 191

Query: 121 NRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRF 180
           +R K  V    GK A T ++V++   +  + V +   TGR+HQ+RVHM  LG+P+LGD  
Sbjct: 192 DRKKMAVVKTNGKTAITYFQVLD-KNEKFSLVKVNIQTGRTHQIRVHMKYLGYPVLGDSV 250

Query: 181 YASPEARAMAPRLLLHAEMLTITHPAYGNSMTF--KAPADF 219
           Y       +A R +LHA  L   HP    +M    + P DF
Sbjct: 251 YGRD--NKIAGRQMLHAYKLEFLHPVTQKAMKIISELPQDF 289


>UniRef50_Q28K21 Pseudouridine synthase n=11 Tax=Proteobacteria RepID=Q28K21_JANSC
          Length = 217

 Score =  278 bits (712), Expect = 1e-73,   Method: Composition-based stats.
 Identities = 117/214 (54%), Positives = 148/214 (69%), Gaps = 3/214 (1%)

Query: 6   YNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDM 65
           Y PP +  L I+++D  +++VNKP+GLLSVPG+ E   D ++ R++  +P+   VHRLDM
Sbjct: 7   YAPPTD-PLDIIHEDHDLLLVNKPAGLLSVPGKGEHLSDCLIARLKIAFPEVLLVHRLDM 65

Query: 66  ATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQ 125
            TSGV+V A T  A+R L  QF +R  KK YVARVWG  +  +G +DLPLI DWPNRP Q
Sbjct: 66  DTSGVMVFARTPHAQRHLGLQFEKRHTKKAYVARVWGEVTDKDGHIDLPLIVDWPNRPLQ 125

Query: 126 KVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPE 185
            V +ETGKPAQT++  +    D T R+ L P TGRSHQLRVHMLA+GHPILGD FYA+  
Sbjct: 126 HVNHETGKPAQTDWRRI-RVEDGTTRMRLFPKTGRSHQLRVHMLAIGHPILGDPFYATGP 184

Query: 186 ARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
           A A  PRL+LHAE L + HP  G  MTF+A   F
Sbjct: 185 ALAF-PRLMLHAESLKLRHPDGGIGMTFRARVPF 217


>UniRef50_Q0VQA6 Pseudouridine synthase n=7 Tax=Gammaproteobacteria
           RepID=Q0VQA6_ALCBS
          Length = 229

 Score =  278 bits (712), Expect = 1e-73,   Method: Composition-based stats.
 Identities = 104/204 (50%), Positives = 133/204 (65%), Gaps = 1/204 (0%)

Query: 17  LYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDMATSGVIVVALT 76
           +Y+D+H++++NKP+ LLSVPGR  E+KD  + R+Q+ YP    VHRLD+ TSG++V  LT
Sbjct: 26  IYRDEHLLLINKPAYLLSVPGRAPENKDCAIRRLQQRYPDIRLVHRLDLDTSGIMVFGLT 85

Query: 77  KAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYETGKPAQ 136
             A+ +L R F+ R  KK+Y A V G      G +DLPLI DWP RP QKVC+ETGK A 
Sbjct: 86  AFAQSKLSRLFQLRTVKKRYQAIVHGLVEKNAGSIDLPLIADWPKRPLQKVCHETGKNAL 145

Query: 137 TEYEVVEYA-ADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARAMAPRLLL 195
           T Y V+E     N  R+ L P+TGRSHQLR+H   LGHPI+G   YA  E  A++PRLLL
Sbjct: 146 THYRVLERDIPGNRTRLALSPVTGRSHQLRIHCRELGHPIIGCDMYAPAEIEALSPRLLL 205

Query: 196 HAEMLTITHPAYGNSMTFKAPADF 219
           HAE L   HP  G    F +P  F
Sbjct: 206 HAEWLAFNHPLTGLWQEFTSPCPF 229


>UniRef50_A6C0W7 Pseudouridine synthase n=1 Tax=Planctomyces maris DSM 8797
           RepID=A6C0W7_9PLAN
          Length = 342

 Score =  277 bits (711), Expect = 1e-73,   Method: Composition-based stats.
 Identities = 82/245 (33%), Positives = 116/245 (47%), Gaps = 32/245 (13%)

Query: 4   ENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDY--------- 54
           +N  PP++  + I+Y+DD I ++NKPS ++  PG+   +  ++   +Q  +         
Sbjct: 83  DNRLPPEDIPIDIVYEDDWIAIINKPSDMIVHPGKG-NYAGTLAGALQYHFDQLSDVAGQ 141

Query: 55  PQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLP 114
            +   VHRLD  TSG++VVA       +L  QF +R+ +K+Y A VWG        +D  
Sbjct: 142 YRPGIVHRLDRNTSGIMVVAKDNQVHAKLSAQFEKRDVQKEYRAIVWGRMEFDTDYIDTF 201

Query: 115 LICDWPNRPKQKVCYETG--KPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALG 172
           +      R K  VC E G  + A T YEV+E        V LKP TGR+HQLRVHM  +G
Sbjct: 202 MCVHPRAREKMIVCDEGGNARNAFTYYEVIERY-QAFTYVRLKPRTGRTHQLRVHMQHIG 260

Query: 173 HPILGDRFYASP-------------------EARAMAPRLLLHAEMLTITHPAYGNSMTF 213
           H I+ DR Y                      E+  +  R  LHA  L   HP  G  M F
Sbjct: 261 HSIVADRVYGGHKSLKMKSLGIQAEADAAELESDVLIERQALHAYCLEFFHPQSGKPMKF 320

Query: 214 KAPAD 218
           +AP  
Sbjct: 321 EAPLP 325


>UniRef50_A9BMW0 Pseudouridine synthase n=10 Tax=Comamonadaceae RepID=A9BMW0_DELAS
          Length = 356

 Score =  277 bits (711), Expect = 1e-73,   Method: Composition-based stats.
 Identities = 78/219 (35%), Positives = 115/219 (52%), Gaps = 11/219 (5%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRD-----YPQAESVHRL 63
           P++  L ++Y+D+H++VVNKP+GL+  P         +   + RD      P+A  VHRL
Sbjct: 120 PEDMALDVVYEDEHLLVVNKPAGLVVHPAPGNWTGTLLNGLLGRDPKAREVPRAGIVHRL 179

Query: 64  DMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSP-AEGLVDLPLICDWPNR 122
           D  TSG++VVA ++AA   L      R+  +QY+A       P     VD P+  D  NR
Sbjct: 180 DKDTSGLMVVARSRAAMDALVAMIAARDVSRQYLALAHKAWGPRKHREVDAPIGRDPRNR 239

Query: 123 PKQKVCY---ETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDR 179
            +  V       GK A+T+ +++    +  + V     TGR+HQ+RVHM +LGHP++ D 
Sbjct: 240 LRMAVVDLAQHAGKTARTDIDLLA-GNEEVSLVRCTLHTGRTHQIRVHMASLGHPLVADA 298

Query: 180 FYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
            Y   EA  MA R  LHA  L  THP  G ++  +AP  
Sbjct: 299 VYGGKEAGGMA-RQALHAFRLAFTHPMTGQALVLRAPLP 336


>UniRef50_A6SXT6 Pseudouridine synthase n=1 Tax=Janthinobacterium sp. Marseille
           RepID=A6SXT6_JANMA
          Length = 342

 Score =  277 bits (711), Expect = 1e-73,   Method: Composition-based stats.
 Identities = 72/222 (32%), Positives = 114/222 (51%), Gaps = 12/222 (5%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR-----DYPQAESVHRL 63
           P+   L I+++D  ++V+NKP+GL+  P         +   +         P+A  VHRL
Sbjct: 110 PEAMDLAIVHEDAEMLVINKPAGLVVHPAAGNWSGTLLNGLLHYLPSISGVPRAGIVHRL 169

Query: 64  DMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRP 123
           D  TSG++VVA T  A  +L RQ + R  K++Y+A VWG P+   G +D  +     +R 
Sbjct: 170 DKDTSGLMVVAKTLIAHTDLVRQLQARTVKREYLALVWGTPNI-TGKIDASIGRHARDRI 228

Query: 124 KQKVCYE-TGKPAQTEYEVVEYA---ADNTARVVLKPITGRSHQLRVHMLALGHPILGDR 179
           K  V    T KPA T ++ +          + ++ +  TGR+HQ+RVHM ++G  ++GD 
Sbjct: 229 KMAVSENLTAKPAVTHFQRLATGMLDGRPVSLMLCRLETGRTHQIRVHMQSIGFALVGDG 288

Query: 180 FYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
            Y       + PR  LHA  L + HP  G ++ + +  P DF
Sbjct: 289 LYGKQHLTTVFPRQALHARRLGLIHPVSGEAVEWSSELPQDF 330


>UniRef50_A9IQ66 Pseudouridine synthase n=5 Tax=Bacteria RepID=A9IQ66_BART1
          Length = 334

 Score =  277 bits (710), Expect = 2e-73,   Method: Composition-based stats.
 Identities = 76/244 (31%), Positives = 109/244 (44%), Gaps = 35/244 (14%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR---------DYPQAESV 60
           +   L ILY+DDH++V+NKP+GL+  PG        V   I              +   V
Sbjct: 77  EAIALDILYEDDHVIVINKPAGLVVHPGNGNWTGTLVNALIYHCGNSLSGIGGVKRPGVV 136

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFRER----EPKKQYVARVWGHPSPAEGLVDLPLI 116
           HRLD  TSGV+VVA    A + L  QF +        ++Y A +WG P      +D  L 
Sbjct: 137 HRLDKNTSGVMVVAKNDLAHKSLSAQFSDHGRTCALDRRYHALIWGTPHRNVWTIDASLG 196

Query: 117 CDWPNRPKQKVCY---ETGKPAQTEYEVVEYAADNT------ARVVLKPITGRSHQLRVH 167
               NR KQ V +      + A T + ++E    +       + +  +  TGR+HQ+RVH
Sbjct: 197 RSPHNRTKQAVVHKQTPHARHAVTHFSLLEKYGTHADSTSFASLLECRLETGRTHQIRVH 256

Query: 168 MLALGHPILGDRFYAS-------------PEARAMAPRLLLHAEMLTITHPAYGNSMTFK 214
           M  +GHP++GD  Y +               A     R  LHA  LT  HP+ G  ++F 
Sbjct: 257 MAHIGHPLIGDTVYGNAFKTKSNTLNPTLKNAIDQFNRHALHAASLTFEHPSSGKVISFS 316

Query: 215 APAD 218
           AP  
Sbjct: 317 APLP 320


>UniRef50_Q3A0C2 Pseudouridine synthase n=13 Tax=Bacteria RepID=Q3A0C2_PELCD
          Length = 326

 Score =  277 bits (709), Expect = 2e-73,   Method: Composition-based stats.
 Identities = 68/230 (29%), Positives = 101/230 (43%), Gaps = 21/230 (9%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYPQAESVH 61
           ++  LVILY+D H++V++KP G++  P         V   +             +   VH
Sbjct: 77  EDIPLVILYEDRHLIVIDKPPGMVVHPAPGHYQGTLVNALLHHCQDLSGIGGELRPGIVH 136

Query: 62  RLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPN 121
           RLD  TSGV+V   T +A + L  QF+     ++Y+A + G  +   G +D P+     +
Sbjct: 137 RLDKDTSGVMVATKTDSAHQSLAAQFKAHSITRRYIALIHGVLTGDRGSIDRPIGRHPTH 196

Query: 122 RPKQKVCYETGKPAQTEYEVVEYA-ADNTARVVLKPITGRSHQLRVHMLALGHPILGDRF 180
           R K      TG+ A T + V+     D    V L   TGR+HQ+RVH     HP+LGD  
Sbjct: 197 RKKMSTTCRTGRHAVTHWRVLRRFDDDRLTLVELALETGRTHQIRVHFSEQQHPLLGDPV 256

Query: 181 YASP------------EARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           Y               +      R  LHA +L   HP  G  + F +P  
Sbjct: 257 YGGSGRLKTINDPQLLKRAKALGRQALHARLLGFQHPETGKYLEFSSPLP 306


>UniRef50_Q2LWV4 Pseudouridine synthase n=1 Tax=Syntrophus aciditrophicus SB
           RepID=Q2LWV4_SYNAS
          Length = 333

 Score =  277 bits (709), Expect = 3e-73,   Method: Composition-based stats.
 Identities = 75/230 (32%), Positives = 108/230 (46%), Gaps = 21/230 (9%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYPQAESV 60
           PQ+  L ILY+D  ++V++KP+GL+  P         V   +             +   V
Sbjct: 80  PQDIPLSILYEDHDLLVLDKPAGLVVHPAAGHVSGTLVNALLFHCRDLAGIGGVMRPGIV 139

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLD  TSG++VVA T AA + L  QF++ +  K Y A V+G P    G +DLP+     
Sbjct: 140 HRLDKDTSGLLVVAKTDAAHQGLALQFKKHQVGKTYQALVYGDPREKTGQIDLPVGRHPV 199

Query: 121 NRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRF 180
            R K       GK A T + + E        + +  +TGR+HQ+RVH+ A+GHP++GD  
Sbjct: 200 ERKKMSTKSRRGKEAATRWRIAERFGV-ATLLNVDIVTGRTHQIRVHLAAIGHPVVGDAV 258

Query: 181 YASPEARAMA------------PRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           Y S +                  R  LHA  L+ THP     + F AP  
Sbjct: 259 YGSSKRATTLTDPAVKGRLKEMSRQALHAARLSFTHPVTHKILEFHAPLP 308


>UniRef50_Q312A0 Pseudouridine synthase, RluD n=6 Tax=Bacteria RepID=Q312A0_DESDG
          Length = 578

 Score =  276 bits (707), Expect = 4e-73,   Method: Composition-based stats.
 Identities = 74/236 (31%), Positives = 113/236 (47%), Gaps = 27/236 (11%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP--------QAESV 60
           P+E  L +LY+D H++V+NKP+GL   P      + +++ R+   +P        +   V
Sbjct: 114 PEEGELEVLYRDAHMLVINKPAGLTVHPAP-SCPEGTLVHRLLHHFPELEAQEGFRPGIV 172

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HR+D  TSG++++ALT+ A   L   F  R   K+Y+A V G P    G +D P+     
Sbjct: 173 HRIDKDTSGLLLIALTEKARLALSDAFAGRRIHKEYLALVKGIPEGDSGEIDAPVGRHPT 232

Query: 121 NRPKQKVCYETGKPAQTEYEVV-----EYAADNTARVVLKPITGRSHQLRVHMLALGHPI 175
           ++ +  V    G+ A + + V+              V ++  TGR+HQ+RVHM   GHP+
Sbjct: 233 HKTRMAVVR-GGREALSTWRVLLADPHGGGGTGWTLVAVRIHTGRTHQIRVHMQHTGHPL 291

Query: 176 LGDRFYASPEARA----------MAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
            GD  Y     R            A R +LHA  ++  HP  G  M F    PADF
Sbjct: 292 WGDALYGGMPGREELQTTPALAQTATRQMLHAWKISFDHPVTGAPMQFTLPPPADF 347


>UniRef50_C7RM94 Pseudouridine synthase n=11 Tax=Proteobacteria RepID=C7RM94_9PROT
          Length = 375

 Score =  276 bits (707), Expect = 4e-73,   Method: Composition-based stats.
 Identities = 80/222 (36%), Positives = 120/222 (54%), Gaps = 14/222 (6%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR-----DYPQAESVHRL 63
           P+E  L I+++DD ++V++K +GL+  PG        +   +         P+A  VHRL
Sbjct: 102 PEEIPLRIVFEDDTLIVLDKQAGLVVHPGSGNWRGTLLNGLLHHAPQLARVPRAGIVHRL 161

Query: 64  DMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRP 123
           D  T+G++VVA T  A+ +L RQ + R  K+ Y A V G    A G+VD P+      R 
Sbjct: 162 DKDTTGLMVVAKTLEAQTDLVRQLQARSVKRCYQALVRGIVEGA-GIVDAPIGRHPTVRT 220

Query: 124 KQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYAS 183
           +  V    G+PA+T Y V+E     T  +     TGR+HQ+RVHM ++ HP++GD  Y  
Sbjct: 221 RMAVV-SGGRPARTHYRVLERFVACT-LIECALETGRTHQIRVHMTSIAHPLVGDPIYGG 278

Query: 184 PEAR----AMAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
             +R    A+ PR  LHA  L + HPA G +M +++  PAD 
Sbjct: 279 GASRVPQGAVFPRQALHACRLALVHPASGKAMLWRSGVPADM 320


>UniRef50_A6DUC9 Pseudouridine synthase n=1 Tax=Lentisphaera araneosa HTCC2155
           RepID=A6DUC9_9BACT
          Length = 323

 Score =  275 bits (706), Expect = 5e-73,   Method: Composition-based stats.
 Identities = 79/234 (33%), Positives = 113/234 (48%), Gaps = 17/234 (7%)

Query: 2   GMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDY------- 54
             E+   P++  L I+Y+DD I+VVNKP+G++  PG        V   + RD        
Sbjct: 78  ADESTLLPEDIELDIIYEDDDILVVNKPAGMVVHPGAGNYTGTLVNALLGRDLDTFSAMD 137

Query: 55  ---PQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLV 111
               +   VHRLD  TSGVI+VA +     +L R F  R+ +K YVA   G        +
Sbjct: 138 DGSSRPGIVHRLDKETSGVIIVAKSAKNLDKLSRSFARRDVEKYYVALCRGTIRVGRDTI 197

Query: 112 DLPLICDWPNRPKQKVCYET--GKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHML 169
              +     NR K +   ++  GK A + Y+V+    +    V LK  TGR+HQ+RVHM 
Sbjct: 198 TSHIGRSRSNRQKMENTNDSNRGKEAISHYKVLA-DNNGATLVKLKIDTGRTHQIRVHMS 256

Query: 170 ALGHPILGDRFYASP--EARAMAPRLLLHAEMLTITHPAYGNSMTFKAPA--DF 219
            + HP++GD+ Y     + +    R +LHA    I HP     MTF AP   DF
Sbjct: 257 GINHPVVGDKLYGVRRLDEKESPDRHILHAWRTRIIHPGTQEIMTFTAPLHDDF 310


>UniRef50_A4VJG2 Pseudouridine synthase n=18 Tax=Bacteria RepID=A4VJG2_PSEU5
          Length = 244

 Score =  275 bits (706), Expect = 5e-73,   Method: Composition-based stats.
 Identities = 106/207 (51%), Positives = 141/207 (68%), Gaps = 2/207 (0%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR-DYPQAESVHRLDMATSGVIV 72
           + I++QD  ++V++KP+ LLSVPGR E+++D ++TR+Q   YP+A  VHRLD  TSG+IV
Sbjct: 39  IQIVHQDAALLVIDKPTLLLSVPGRAEDNRDCLVTRLQENGYPEARIVHRLDWETSGLIV 98

Query: 73  VALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYETG 132
           +A    + REL RQF +RE +K Y A  WG P    G +DLPL  D P +P+  V  E G
Sbjct: 99  LARDADSHRELSRQFHDRETEKAYTALCWGQPDADSGSIDLPLRYDPPTKPRHVVDPELG 158

Query: 133 KPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARAMAPR 192
           K A T + V+E   D+ +RV L PITGRSHQLRVHML++GHP+LGDR YA  +A     R
Sbjct: 159 KHALTFWRVLERCGDH-SRVELTPITGRSHQLRVHMLSIGHPLLGDRLYAHEQALRAHER 217

Query: 193 LLLHAEMLTITHPAYGNSMTFKAPADF 219
           L LHA MLT+THP  G  + F++PA F
Sbjct: 218 LCLHASMLTLTHPQTGARLRFESPAPF 244


>UniRef50_A5WFS2 Pseudouridine synthase n=3 Tax=Psychrobacter RepID=A5WFS2_PSYWF
          Length = 420

 Score =  275 bits (706), Expect = 5e-73,   Method: Composition-based stats.
 Identities = 74/231 (32%), Positives = 113/231 (48%), Gaps = 20/231 (8%)

Query: 7   NPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRI-----QRDYPQAESVH 61
           + P++  L I+Y+DD ++V+NKP G++  PG        V   +     Q   P+A  VH
Sbjct: 174 DQPEDIKLDIIYEDDSVIVINKPVGMVVHPGAGNWSGTLVNGLLYHYPNQAHLPRAGLVH 233

Query: 62  RLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSP--AEGLVDLPLICDW 119
           R+D  TSG++V+  TKAA+ EL+ Q +++   + Y   V G       +  +D P+    
Sbjct: 234 RIDKNTSGLLVIGKTKAAQLELQEQLKDKSVYRHYQCVVAGDAPSLARQRTIDAPIGRHR 293

Query: 120 PNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDR 179
             R K  V   TGK A T    +   +D  + + ++  TGR+HQ+RVH+  +GHPI+GD 
Sbjct: 294 TQRTKMTV-TSTGKTAITHIMKITPLSDTYSLLDVRLETGRTHQIRVHLSHIGHPIIGDD 352

Query: 180 FYAS------------PEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
            Y +             +A    PR  LHA  L   HP  G S+   AP  
Sbjct: 353 IYGNRQQLRAGLTPEQRQAIQSFPRQALHAYKLGFIHPETGESIELTAPLP 403


>UniRef50_B9JRD0 Pseudouridine synthase n=1 Tax=Agrobacterium vitis S4
           RepID=B9JRD0_AGRVS
          Length = 342

 Score =  275 bits (706), Expect = 5e-73,   Method: Composition-based stats.
 Identities = 74/243 (30%), Positives = 107/243 (44%), Gaps = 34/243 (13%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR---------DYPQAESV 60
           ++  L +LY+D  ++V++KP+GL+  PG        V   I              +   V
Sbjct: 86  EDIPLTVLYEDKDLIVLSKPAGLVVHPGAGNWTGTLVNALIHHCGDSLSGIGGVKRPGIV 145

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFRERE----PKKQYVARVWGHPSPAEGLVDLPLI 116
           HRLD  TSGV+VVA    A R L  QF +       ++ Y A VWG P    G +D  L 
Sbjct: 146 HRLDKETSGVMVVAKNDIAHRHLADQFADHGRSGPLERAYQALVWGRPRGLRGTIDAALG 205

Query: 117 C--DWPNRPKQKVCYETGKPAQTEYEVVEYAADN------TARVVLKPITGRSHQLRVHM 168
              D   R  ++   +  + A T Y+V+E   +        + V  +  TGR+HQ+RVHM
Sbjct: 206 RAGDRTKRTVKREDTDDAREAITHYQVMERYGEKPDATCLASLVECRLETGRTHQIRVHM 265

Query: 169 LALGHPILGDRFYA-------------SPEARAMAPRLLLHAEMLTITHPAYGNSMTFKA 215
             +GHP++GD  Y              +        R  LHA +L   HP  G+ M F A
Sbjct: 266 AHIGHPLIGDPEYGAAFKTKANLLPDAAKAIVTNFHRQALHAYLLAFEHPTTGDVMHFAA 325

Query: 216 PAD 218
           P  
Sbjct: 326 PIP 328


>UniRef50_A7HV45 Pseudouridine synthase n=56 Tax=Alphaproteobacteria
           RepID=A7HV45_PARL1
          Length = 482

 Score =  275 bits (704), Expect = 8e-73,   Method: Composition-based stats.
 Identities = 81/241 (33%), Positives = 106/241 (43%), Gaps = 32/241 (13%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR---------DYPQAESV 60
           Q   L I+Y+D  ++VV KP+GL+  P         V   +              +   V
Sbjct: 222 QAIPLEIVYEDADLIVVMKPAGLVVHPAPGNPDMTLVNALVAHCGETLSGIGGEKRPGIV 281

Query: 61  HRLDMATSGVIVVALTKAAERELKRQF----REREPKKQYVARVWGHPSPAEGLVDLPLI 116
           HRLD  TSG++VVA T  A + L  QF    R+ +  + Y A  WG P   +G VD  + 
Sbjct: 282 HRLDKETSGLMVVAKTDRAHQGLSAQFAAHGRDGKLTRAYTALTWGVPQTRKGTVDANIA 341

Query: 117 CDWPNRPKQKVCYETGKP-----AQTEYEV-VEYAADNTARVVLKPITGRSHQLRVHMLA 170
               NR K     + G+      A T Y V  +YA    A V  +  TGR+HQ+RVHM A
Sbjct: 342 RSSHNRSKMATVRDRGEETGGRIAITHYTVKTDYADGLVAEVECRLETGRTHQIRVHMTA 401

Query: 171 LGHPILGDRFYASP-------------EARAMAPRLLLHAEMLTITHPAYGNSMTFKAPA 217
           LGHP+LGD  Y +               A     R  LHA  L   HP  G  M+F AP 
Sbjct: 402 LGHPLLGDATYGTGMKSRKSKLSPEAQAALERLNRQALHAHHLGFEHPVAGEKMSFDAPL 461

Query: 218 D 218
            
Sbjct: 462 P 462


>UniRef50_Q12L72 Pseudouridine synthase n=17 Tax=Shewanella RepID=Q12L72_SHEDO
          Length = 230

 Score =  274 bits (703), Expect = 1e-72,   Method: Composition-based stats.
 Identities = 107/219 (48%), Positives = 136/219 (62%), Gaps = 2/219 (0%)

Query: 1   MGMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESV 60
           M + NY PP  PWL I Y D  I+V+NKPSGLLS PGR  E  D+ +TR+QR YP+   +
Sbjct: 14  MQVFNYQPPSIPWLDIRYLDRDIIVINKPSGLLSNPGRAPETYDTAITRLQRLYPETILI 73

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLD  TSG+++ A  K AE  LK QF+ R+ KK Y+A V G     +G V+ PL  D  
Sbjct: 74  HRLDCDTSGIMIFARNKKAESNLKTQFQNRQAKKVYIAEVSGCFEHQDGKVNFPLGPDPM 133

Query: 121 NRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRF 180
             P Q+V  E+GKPA T Y ++E+ A  T+ V LKP TGR+HQLRVHM ALGH I+GD F
Sbjct: 134 TPPFQQVI-ESGKPALTYYRLLEHRAS-TSLVELKPHTGRTHQLRVHMKALGHTIIGDEF 191

Query: 181 YASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
           Y      A + RL LHA+ LT+ HP     + F +   F
Sbjct: 192 YGDETVIAASHRLNLHAQSLTLLHPFKQIEIQFFSQHPF 230


>UniRef50_D0MJ49 Pseudouridine synthase n=2 Tax=Bacteria RepID=D0MJ49_RHOM4
          Length = 355

 Score =  274 bits (703), Expect = 1e-72,   Method: Composition-based stats.
 Identities = 81/256 (31%), Positives = 108/256 (42%), Gaps = 52/256 (20%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRI----------------------- 50
           L I+Y+D +++VVNK +GL+  P R       V   +                       
Sbjct: 86  LDIVYEDPYLIVVNKQAGLVVHPARGNRSGTLVNALLYYIGSGPVRFDEEDDLPEDDEIG 145

Query: 51  -----------QRDYPQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVAR 99
                      + + P+   VHRLD  T+G+IVVA        L RQF  R   + Y+A 
Sbjct: 146 LSMVSTGPTEAKLEAPRPGIVHRLDKDTTGLIVVAKDDVTHTGLARQFEHRTIARTYLAI 205

Query: 100 VWGHPSPAEGLVDLPLICDWPNRPKQKVCYET-GKPAQTEYEVVEYAADNTARVVLKPIT 158
           VWG P P  G ++  +  D  +R +  V  +  GK A T YEVVE      A V  K  T
Sbjct: 206 VWGVPDPPRGRIEAAIGRDPRDRQRMAVVPDDRGKRAVTHYEVVEALPA-AALVRFKLET 264

Query: 159 GRSHQLRVHMLALGHPILGDRFYASPEAR----------------AMAPRLLLHAEMLTI 202
           GR+HQ+RVH   +GHP+LGD  Y     R                A   R  LHA  L  
Sbjct: 265 GRTHQIRVHARHIGHPVLGDPTYGGRTIRYGPHTPRRRAFYDQLFARLTRQALHAHTLGF 324

Query: 203 THPAYGNSMTFKAPAD 218
            HP  G  + F+AP  
Sbjct: 325 RHPRTGEWLEFEAPLP 340


>UniRef50_A3M2Y1 Pseudouridine synthase n=18 Tax=Gammaproteobacteria
           RepID=A3M2Y1_ACIBT
          Length = 350

 Score =  274 bits (703), Expect = 1e-72,   Method: Composition-based stats.
 Identities = 73/238 (30%), Positives = 112/238 (47%), Gaps = 22/238 (9%)

Query: 1   MGMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR-----DYP 55
           +  +  + P+   L I+Y+D+ I+V+NKP G++  PG        V   +       +  
Sbjct: 102 LEAQTNSQPENIPLDIVYEDEDILVINKPVGMVVHPGAGNTSSTLVNALLYHSPKSAELS 161

Query: 56  QAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPL 115
           +A  VHR+D  TSG++VVA    A+  L +Q  ++   + Y    +G+   A G +D P+
Sbjct: 162 RAGLVHRIDKDTSGLLVVAKNLEAQFSLSKQLGDKSVYRIYDLVTYGNII-AGGTIDEPI 220

Query: 116 ICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPI 175
                +R K  +    G+ A T Y V E   D   RV  +  TGR+HQ+RVH   +GH +
Sbjct: 221 KRHPVDRVKMAIL-PGGRDAVTHYNVKERFRD-FTRVQAQLETGRTHQIRVHFSYIGHGL 278

Query: 176 LGDRFYASP------------EARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
           +GD+ Y +             E      R  LHA  L + HP  G  M F+A  P DF
Sbjct: 279 VGDQVYMNRVRIPAGASELLIETLRGFKRQALHAAKLGLKHPRTGEEMLFEAPWPEDF 336


>UniRef50_Q1ILA4 Pseudouridine synthase n=1 Tax=Candidatus Koribacter versatilis
           Ellin345 RepID=Q1ILA4_ACIBL
          Length = 333

 Score =  274 bits (703), Expect = 1e-72,   Method: Composition-based stats.
 Identities = 76/239 (31%), Positives = 117/239 (48%), Gaps = 29/239 (12%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRL----EEHKDSVMTRIQRDYP--------- 55
           P++  L ++Y+DD + V+NKP+G++   G      E ++ +++  +   +          
Sbjct: 77  PEDIPLDVVYEDDDLAVINKPAGMMVHVGAGATEEERNRGTLVNALLYRFRALSEVGGDM 136

Query: 56  QAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPL 115
           +   VHRLD  TSG+IVVA    A R+L  QF  R   K+YVA V G P   +G ++LP+
Sbjct: 137 RPGIVHRLDKETSGLIVVAKNDVAHRKLAEQFSSRRVHKKYVALVHGWPKKLKGTINLPI 196

Query: 116 ICDWPNRPKQKVCYETGKPAQTEYEV---VEYAADNTARVVLKPITGRSHQLRVHMLALG 172
             D   R +       G+ A + YEV   +E      A V +K  TGR+HQ+RVHM +LG
Sbjct: 197 ARDMSRRTRMTTRGSGGRDALSHYEVKEKIESPYGKFALVEVKIETGRTHQIRVHMASLG 256

Query: 173 HPILGDRFYASPEARAMAP-------------RLLLHAEMLTITHPAYGNSMTFKAPAD 218
           HP++GD  Y +P    +               R  LHA  + +  PA G ++ F     
Sbjct: 257 HPVVGDTLYGAPGELRVTKALKGMPSKMASLERNFLHAAEIELQQPATGKALRFVTKVP 315


>UniRef50_B8FLB4 Pseudouridine synthase n=2 Tax=Bacteria RepID=B8FLB4_DESAA
          Length = 321

 Score =  274 bits (701), Expect = 2e-72,   Method: Composition-based stats.
 Identities = 75/229 (32%), Positives = 106/229 (46%), Gaps = 21/229 (9%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYPQAESVH 61
           Q+  L ILY+D  I+ VNKP G++  P         V   +             +   VH
Sbjct: 79  QDMDLAILYEDRDIVAVNKPPGMVVHPAPGHSSNTLVNALLAHCKDLSGIGGVQRPGIVH 138

Query: 62  RLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPN 121
           RLD  TSGVI+ A   AA   L  Q  +R  +K Y+A   G      G++DLPL     +
Sbjct: 139 RLDKETSGVILAAKNDAAHAGLSEQLAQRRVEKFYLALAHGVIKEDTGVIDLPLARHPSD 198

Query: 122 RPKQKVCYE-TGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRF 180
           R +  V     G+ A + + V E   D    V ++  TGR+HQ+RVH+ AL HP++GD  
Sbjct: 199 RKRMHVSTPAKGREALSLWTVKERFLD-ATYVKVQIKTGRTHQIRVHLAALHHPVIGDTV 257

Query: 181 YASPEARAMAP-----------RLLLHAEMLTITHPAYGNSMTFKAPAD 218
           Y   + R   P           R +LHA +++ THP  G  +T  AP  
Sbjct: 258 YGGRKKRGRLPASVLGKAPPPERQMLHAHIVSFTHPVTGEKLTLTAPLP 306


>UniRef50_D1RB31 Pseudouridine synthase n=1 Tax=Parachlamydia acanthamoebae str.
           Hall's coccus RepID=D1RB31_9CHLA
          Length = 319

 Score =  274 bits (701), Expect = 2e-72,   Method: Composition-based stats.
 Identities = 75/222 (33%), Positives = 108/222 (48%), Gaps = 16/222 (7%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR----------DYPQAE 58
           P++  L ILY+D+H++++NKP G++  P         V   +            D  +  
Sbjct: 82  PEQIPLNILYEDEHLLIINKPVGMVVHPAPGNWTGTFVNALLYHCGYSLSDASVDSIRPG 141

Query: 59  SVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICD 118
            VHRLD  TSGV+V A T + +++L   F  R+  K+Y A   G+P   E  ++ P+   
Sbjct: 142 IVHRLDKETSGVLVAAKTLSVQQKLMELFAARQVYKEYWAICLGNPGNCE--LNWPIGRH 199

Query: 119 WPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGD 178
             +R KQ    E GK A T  E +E   +      L   TGR+HQ+RVH+   GHPILGD
Sbjct: 200 PIHR-KQMTVREDGKEALTFCETLE-VGNEICLAKLILSTGRTHQIRVHLKHKGHPILGD 257

Query: 179 RFYASPE--ARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
             Y S +   R  A R +LHA  L   HP     +  +AP  
Sbjct: 258 SIYGSKQVNMRYRAERQMLHARKLAFIHPITQQKIEVEAPLP 299


>UniRef50_C6WV38 Pseudouridine synthase n=3 Tax=Proteobacteria RepID=C6WV38_METML
          Length = 368

 Score =  274 bits (701), Expect = 2e-72,   Method: Composition-based stats.
 Identities = 82/223 (36%), Positives = 114/223 (51%), Gaps = 21/223 (9%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRI-----QRDYPQAESVHRLD 64
           Q+  L I+Y+DDHI+VVNKP+G++  P         +   +       D P+A  VHRLD
Sbjct: 86  QDIPLDIVYEDDHILVVNKPAGMVVHPAAGNWDGTLLNALLFHAPQLHDVPRAGIVHRLD 145

Query: 65  MATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPK 124
             TSG++VVA T  A+  L RQ + R  K++Y A VWG      G+VD PL  D  +R K
Sbjct: 146 KETSGLLVVAKTLNAQTHLVRQLQARTVKREYRAIVWGQL-WRNGVVDQPLGRDPRSRTK 204

Query: 125 QKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYAS- 183
             +    GKPA T YE++E  +  T  +     TGR+HQ+RVHM  L  P++GD  Y   
Sbjct: 205 MAI-NRMGKPAITRYEILERFSVQT-YLRCNLETGRTHQIRVHMQHLKAPLVGDPVYGFR 262

Query: 184 ------------PEARAMAPRLLLHAEMLTITHPAYGNSMTFK 214
                        +A +   R  LHA  L + HPA    M ++
Sbjct: 263 GIVPIRAMTQTLRDAVSQFHRQALHAIKLGLVHPATNEFMEWQ 305


>UniRef50_A1URK8 Pseudouridine synthase n=2 Tax=Bartonella RepID=A1URK8_BARBK
          Length = 336

 Score =  273 bits (700), Expect = 3e-72,   Method: Composition-based stats.
 Identities = 82/244 (33%), Positives = 113/244 (46%), Gaps = 35/244 (14%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR---------DYPQAESV 60
           +   L IL++DDHI+VVNKP+GL+  PG        V   I              +   V
Sbjct: 76  EAIPLHILFEDDHIIVVNKPAGLVVHPGHGNWTGTLVNALIYHCGDSLSGIGGVRRPGIV 135

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFRER----EPKKQYVARVWGHPSPAEGLVDLPLI 116
           HRLD  TSGVIVVA    A + L  QF +        ++Y A +WG P+   G++   L 
Sbjct: 136 HRLDKNTSGVIVVAKNDLAHKGLSAQFSDHGRTGVLDRRYHALIWGSPNRNIGVITASLG 195

Query: 117 CDWPNRPKQKVCYET---GKPAQTEYEVVEYAAD------NTARVVLKPITGRSHQLRVH 167
               +R KQ V +      + A T + V+E            + +  +  TGR+HQ+RVH
Sbjct: 196 RARYDRTKQAVIHSHNIYARHAVTHFSVIEKYQTCADKIPFASLLECRLETGRTHQIRVH 255

Query: 168 MLALGHPILGDRFYAS-------------PEARAMAPRLLLHAEMLTITHPAYGNSMTFK 214
           M  +GHP++GD  Y +              EA  +  R  LHA  LT  HPA GN M+F 
Sbjct: 256 MAHIGHPLVGDTVYGNAFKTKSNRFDSTIKEAIDLFNRQALHAASLTFEHPAKGNIMSFS 315

Query: 215 APAD 218
           AP  
Sbjct: 316 APLP 319


>UniRef50_O50310 Uncharacterized RNA pseudouridine synthase Cpar_0723 n=13
           Tax=Chlorobiaceae RepID=Y723_CHLP8
          Length = 327

 Score =  273 bits (699), Expect = 4e-72,   Method: Composition-based stats.
 Identities = 72/238 (30%), Positives = 104/238 (43%), Gaps = 29/238 (12%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP----------QAE 58
           P++  + ILY+DD +MV++K +G++  P             +               +  
Sbjct: 72  PEDIPITILYEDDDLMVIDKEAGMVVHPAFGNWTGTLANAILHHLGKDADELDKTEMRPG 131

Query: 59  SVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICD 118
            VHRLD  TSG+I++A    A  +L RQF  R+ +K Y A VWG P    G +   +   
Sbjct: 132 IVHRLDKDTSGLIIIAKNPTALHKLARQFANRQVEKVYKAIVWGVPKAESGTIKTNIGRS 191

Query: 119 WPNRPKQKVCY---ETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPI 175
             NR            GK A T+Y+VVE      + + +   TGR+HQ+RVH+  LGH I
Sbjct: 192 HKNRKVMANFPYEGAEGKHAITDYQVVEDLG-YFSLMDVTLHTGRTHQIRVHLQHLGHSI 250

Query: 176 LGDRFYASPEARA---------------MAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           LGD  Y     R                +  R  LHA+ L    P  G  ++F AP  
Sbjct: 251 LGDETYGGATPRTLPFSKSEPFTRNLLELMSRQALHAQTLRFRQPTTGEPLSFSAPLP 308


>UniRef50_B7BE87 Pseudouridine synthase n=8 Tax=Bacteroidales RepID=B7BE87_9PORP
          Length = 551

 Score =  272 bits (698), Expect = 4e-72,   Method: Composition-based stats.
 Identities = 96/222 (43%), Positives = 126/222 (56%), Gaps = 19/222 (8%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAE---SVHRLDMA 66
           ++  L I+Y+D+ ++VVNKP+G+LSVPG+ +   DSV  R++R YP A     VHRLDMA
Sbjct: 333 RDAELEIVYEDESLLVVNKPAGMLSVPGKSD--VDSVYQRVRRMYPGATGPMVVHRLDMA 390

Query: 67  TSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQK 126
           TSG+++VA TK   + L+ QF+ R   K+YVA + G     EG ++LPL  D  +RP+Q 
Sbjct: 391 TSGLMLVAKTKEVHQNLQAQFKNRTVCKRYVAWLDGIVEEKEGHLELPLRPDPEDRPRQV 450

Query: 127 VCYETGKPAQTEYEVVEYAADNTAR------VVLKPITGRSHQLRVHMLA---LGHPILG 177
           V    GKPA T+Y V+ Y             V   P TGR+HQLRVH      L  PI+G
Sbjct: 451 VDVVHGKPAVTDYRVLRYGGCKGGLRTTPTVVSFVPKTGRTHQLRVHSAHPLGLNAPIVG 510

Query: 178 DRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
           D  Y        A RL LHAE L  THP  G  M  +  A F
Sbjct: 511 DELYGKK-----ADRLYLHAEYLGFTHPVSGVYMEVEKEAGF 547


>UniRef50_B8J173 Pseudouridine synthase, RluA family n=2 Tax=Desulfovibrio
           RepID=B8J173_DESDA
          Length = 525

 Score =  272 bits (697), Expect = 6e-72,   Method: Composition-based stats.
 Identities = 87/221 (39%), Positives = 120/221 (54%), Gaps = 13/221 (5%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP--------QAESV 60
           P+E  L +L+QDDH++V NKP+GL   P      + +++ R+   +P        +   V
Sbjct: 75  PEEGHLELLWQDDHLVVCNKPAGLTVHPCP-SCPEQTLVQRLLGRFPQLSRLEGQRPGIV 133

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLD  TSG++VVALT+A    L   F ER+  K+Y+A V G   P EG    PL     
Sbjct: 134 HRLDKDTSGLLVVALTEADCLALAAAFAERQVHKEYLALVSG-LPPLEGQCREPLGRHPT 192

Query: 121 NRPKQKVCYET--GKPAQTEYEVVEYAADN-TARVVLKPITGRSHQLRVHMLALGHPILG 177
            + K  V  E   G+ A TE+  +    D   + + ++  TGR+HQ+RVHM  LG+P+LG
Sbjct: 193 AKIKMAVVPEDQGGRNAFTEWRRLWNTDDGSVSLLAVRIHTGRTHQIRVHMTHLGYPLLG 252

Query: 178 DRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           DR YA    + MAPR +LHA  L  THPA G  M F  P  
Sbjct: 253 DRLYAPKAVQNMAPRQMLHAWRLGFTHPASGEDMRFTCPPP 293


>UniRef50_D2L0S2 Pseudouridine synthase, RluA family n=1 Tax=Desulfovibrio sp.
           FW1012B RepID=D2L0S2_9DELT
          Length = 558

 Score =  272 bits (696), Expect = 7e-72,   Method: Composition-based stats.
 Identities = 75/228 (32%), Positives = 111/228 (48%), Gaps = 20/228 (8%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP--------QAESVH 61
           +   L +LY D  + V++KP GL   P      + +++ R+   +P        +   VH
Sbjct: 87  EAGSLRVLYADKELAVLDKPPGLTVHPAPGLP-EGTLVNRLLHHFPGLREMAGERPGIVH 145

Query: 62  RLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPN 121
           RLD  TSG+++VALT+     L   F  R+  K Y+A V G P    G + LP+  D   
Sbjct: 146 RLDKDTSGLLMVALTEPVRLALAADFAARQVHKTYLALVHGRPDGKGGDIRLPIGRDPKY 205

Query: 122 RPKQKVCYETGKPAQTEYEVVEYAADNT-ARVVLKPITGRSHQLRVHMLALGHPILGDRF 180
           R K  V ++ G+PA + +  V  A D T + + +   TGR+HQ+RVHM A+GHPI+GD  
Sbjct: 206 RTKMAVPHKGGRPAHSRWRPVWTAPDGTASLLEVTIFTGRTHQIRVHMAAIGHPIIGDAV 265

Query: 181 YA----------SPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           Y                 +A R +LHA  L+ THP      +F  P  
Sbjct: 266 YGPHQHAAWKRRGGAIARLASRQMLHAWKLSFTHPVLKEPRSFTCPPP 313


>UniRef50_C8PVB8 Pseudouridine synthase n=2 Tax=Moraxellaceae RepID=C8PVB8_9GAMM
          Length = 380

 Score =  271 bits (695), Expect = 9e-72,   Method: Composition-based stats.
 Identities = 72/235 (30%), Positives = 108/235 (45%), Gaps = 25/235 (10%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRI-----QRDYPQAESVHRL 63
           P+   L ILY+D+ ++V+NKP GL+  PG        V   +      R  P+A  VHR+
Sbjct: 138 PENIPLDILYEDEAVLVINKPVGLVVHPGAGNGSGTLVNALLFHYPDSRTLPRAGLVHRI 197

Query: 64  DMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSP--AEGLVDLPLICDWPN 121
           D  TSG++V+A    ++  L  Q +++   + Y A V    +       +D P+      
Sbjct: 198 DKETSGLMVIAKDSQSQLHLINQLKDKSVYRLYQAIVLASAAELARHRTIDAPIGRHPTQ 257

Query: 122 RPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFY 181
           R K  V   +GKPA T  E +   +D  + V ++  TGR+HQ+RVH+  LG P+LGD  Y
Sbjct: 258 RTKMAVV-SSGKPAVTHLEKITAISDAVSLVSVRLETGRTHQIRVHLSNLGFPLLGDPLY 316

Query: 182 ASPEARAMA---------------PRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
            +    A+                 R  LHA  L   HP  G  +  +A  P D 
Sbjct: 317 GAARKNAILLKTLDDDQKHIVQQFQRQALHAYELGFIHPKTGEPIKVQARLPEDM 371


>UniRef50_Q3AVX8 Pseudouridine synthase n=40 Tax=cellular organisms
           RepID=Q3AVX8_SYNS9
          Length = 339

 Score =  271 bits (695), Expect = 1e-71,   Method: Composition-based stats.
 Identities = 72/224 (32%), Positives = 113/224 (50%), Gaps = 13/224 (5%)

Query: 6   YNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP---------Q 56
           Y  PQ   L +L++D+HI+V+NK +GL   P    +   +++  +    P         +
Sbjct: 98  YLKPQPMDLDVLFEDEHIIVLNKSAGLTVHPAPGNKDG-TLVNGLLHHCPDLPGISGKLR 156

Query: 57  AESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLI 116
              VHRLD  TSG IVVA ++ A  +L+ Q ++R   ++Y A V G P    G +   + 
Sbjct: 157 PGIVHRLDKDTSGCIVVAKSQEALVKLQVQIQKRVASREYFAVVHGVPDGDSGTIIGAVG 216

Query: 117 CDWPNRPKQKVC-YETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPI 175
               +R K  V   E+G+ A+T + ++E   D  + +  K  TGR+HQ+RVH   + HP+
Sbjct: 217 RHPVDRKKYAVVSDESGRYARTHWTLIERFGD-YSLLRFKLDTGRTHQIRVHCAHINHPV 275

Query: 176 LGDRFYAS-PEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           +GD  Y+   +     P   LHA  L + HP  G  M F+AP  
Sbjct: 276 VGDPTYSRCRKLPLDLPGQALHAVQLGLDHPITGERMVFEAPLP 319


>UniRef50_B2RIT5 Pseudouridine synthase n=80 Tax=root RepID=B2RIT5_PORG3
          Length = 365

 Score =  271 bits (695), Expect = 1e-71,   Method: Composition-based stats.
 Identities = 76/240 (31%), Positives = 113/240 (47%), Gaps = 31/240 (12%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSV--MTRIQRDYPQ-------AES 59
           P++  L I+Y+DD ++V+NKP+GL+  PG        V  +    R+ P+          
Sbjct: 105 PEDIPLDIVYEDDVLLVINKPAGLVVHPGHGNYTGTLVNALAYYLREDPEYDPMDPSLGL 164

Query: 60  VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDW 119
           VHR+D  TSG++VVA    A+ +L +QF  +   + Y A VWG      G +   +  D 
Sbjct: 165 VHRIDKDTSGLLVVAKRAEAKSDLCKQFYYKTTHRSYRALVWGRFDYPIGTITGNIGRDL 224

Query: 120 PNRPKQKVCYET---GKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPIL 176
            +R +  V       GKPA T Y+V+E  A   + +  +  TGR+HQ+R HM  +GH + 
Sbjct: 225 KDRLQMAVFPPDGDIGKPAVTHYQVLEELA-YVSWIECRLETGRTHQIRAHMKHIGHTLF 283

Query: 177 GDRFYASPE----------------ARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PAD 218
            D  Y   +                  A+ PR  LHA+ L   HP  G  M F +  PAD
Sbjct: 284 ADERYGGDQILRGNNTANYRRFVQNCLAICPRQALHAKTLGFRHPVTGVEMQFDSDIPAD 343


>UniRef50_Q87AR7 Ribosomal large subunit pseudouridine synthase D n=18
           Tax=Gammaproteobacteria RepID=RLUD_XYLFT
          Length = 331

 Score =  270 bits (693), Expect = 2e-71,   Method: Composition-based stats.
 Identities = 82/227 (36%), Positives = 110/227 (48%), Gaps = 20/227 (8%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRD-----YPQAESVHRL 63
           PQ+  L ILY+D+H+ V+NKP+GL+  PG        V   + RD      P+A  VHRL
Sbjct: 85  PQDIPLDILYEDEHVFVINKPAGLVVHPGAGNPDGTLVNALLHRDPALAAVPRAGVVHRL 144

Query: 64  DMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRP 123
           D  TSGV+VVA T  A+  L  Q   R+  +QY+A V        G V+  +     +R 
Sbjct: 145 DKDTSGVMVVARTLQAQTALVEQLSSRQVHRQYLAVVVSALVSG-GTVNAAIERHPRDRL 203

Query: 124 KQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYAS 183
           + +V  +TGK A T Y + E    +TA    +  TGR+HQ+RVHM  L HPI+GDR Y  
Sbjct: 204 RMEV-SDTGKEAVTHYRLRERFRAHTAL-ECRLDTGRTHQIRVHMAHLRHPIVGDRLYGG 261

Query: 184 P------------EARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
                               R  LHAE+L   HP     +   AP  
Sbjct: 262 SLKLPKGGTDALVAMLRGFKRQALHAEVLEFLHPVRALPVRIVAPVP 308


>UniRef50_C4XSN0 Ribosomal large subunit pseudouridine synthase D/dephospho-CoA
           kinase n=1 Tax=Desulfovibrio magneticus RS-1
           RepID=C4XSN0_DESMR
          Length = 554

 Score =  270 bits (692), Expect = 2e-71,   Method: Composition-based stats.
 Identities = 77/231 (33%), Positives = 125/231 (54%), Gaps = 22/231 (9%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP--------QAESVH 61
           ++  L +LY D  ++V+NKP+GL   P   +    +++ R+   +P        +   VH
Sbjct: 89  EDGELKLLYLDGDVLVLNKPAGLTIHPASSQPDG-TLVNRLLHHFPDMRAMAGDRPGIVH 147

Query: 62  RLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPN 121
           RLD  TSG+++VA T++A   L   F ER   K Y+A V G P  ++G+++LP+  D  +
Sbjct: 148 RLDKDTSGLLLVAQTESARLALAADFAERRVAKTYLALVHGRPERSDGVIELPVGRDPKH 207

Query: 122 RPKQKVCYETGKPAQTEYEVVEYAADNT-ARVVLKPITGRSHQLRVHMLALGHPILGDRF 180
             K  V  + G+ A++ +++   A D T + + +   TGR+HQ+RVHM A+GHPI+GD  
Sbjct: 208 PTKMAVVAKGGREAKSSWKLAWTAPDGTASLLEVAIATGRTHQIRVHMAAMGHPIVGDAV 267

Query: 181 YASPEAR----------AMAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
           Y + +             +A R +LHA  L  +HP  G  ++F    PADF
Sbjct: 268 YGARQHSDWTRRGGAMARLAKRQMLHAWKLAFSHPGTGEELSFCQPPPADF 318


>UniRef50_Q8XYX8 Ribosomal large subunit pseudouridine synthase D n=94
           Tax=Proteobacteria RepID=RLUD_RALSO
          Length = 358

 Score =  270 bits (691), Expect = 3e-71,   Method: Composition-based stats.
 Identities = 83/237 (35%), Positives = 123/237 (51%), Gaps = 23/237 (9%)

Query: 4   ENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRD-----YPQAE 58
           EN    +   L ++Y+DD ++V+NKP+GL+  P         +   + R       P+A 
Sbjct: 106 ENAFVAEPVDLDVVYEDDTLLVINKPAGLVVHPAAGNWSGTVLNGLLHRYPQAAGLPRAG 165

Query: 59  SVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICD 118
            VHRLD  TSG++VVA T  A+ +L RQ + R  K+ Y+A VWG  +P  G +D P+  D
Sbjct: 166 IVHRLDKETSGLMVVARTLPAQTDLVRQLQARTVKRTYLALVWGE-TPEAGTIDAPIGRD 224

Query: 119 WPNRPKQKVC-YETGKPAQTEYE---VVEYAADNTARVVLKPITGRSHQLRVHMLALGHP 174
             +R +  +    +GKPA+T ++   VV+      + V  +  TGR+HQ+RVH  + GHP
Sbjct: 225 PRDRTRMAIIETASGKPARTHFKTLDVVDLGRAQVSLVQCQLETGRTHQIRVHFESEGHP 284

Query: 175 ILGDRFY------ASPEA-----RAMAPRLLLHAEMLTITHPAYGNSMTFKA--PAD 218
           +LGD  Y        P+       A   R  LHA  L + HPA G S+ + A  P D
Sbjct: 285 LLGDPVYTRNFRRGRPQTIKAPLPAPFARQALHAVRLGLVHPASGQSVHWHAGVPDD 341


>UniRef50_P74346 Uncharacterized RNA pseudouridine synthase slr1629 n=19
           Tax=Bacteria RepID=Y1629_SYNY3
          Length = 327

 Score =  270 bits (691), Expect = 3e-71,   Method: Composition-based stats.
 Identities = 70/220 (31%), Positives = 113/220 (51%), Gaps = 12/220 (5%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYPQAESVH 61
           Q   L ILY+D+ ++++NKP+GL+  PG        V   +             +   VH
Sbjct: 94  QNIPLDILYEDEQLIIINKPAGLVVHPGPGHPDGTVVNALLAHCPDLAGIGGVQRPGIVH 153

Query: 62  RLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPN 121
           RLD  T+G +VVA T+ A   L+ Q +E+  ++ Y   V+G P   +G V+LP+     +
Sbjct: 154 RLDKDTTGAMVVAKTELALHNLQVQLKEKTARRLYWGIVYGSPKEIQGTVNLPVGRHPGD 213

Query: 122 RPKQKVCY--ETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDR 179
           R K  +    + G+ A T + ++E   ++ + +  +  TGR+HQ+RVH   +GHP++GD 
Sbjct: 214 RQKMGIVPVEKGGREAVTHWRLLERIGNH-SWLEFQLETGRTHQIRVHSKQMGHPLVGDN 272

Query: 180 FYASPEA-RAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
            Y SP +     P   LHA  L++ HP  G  +T  AP  
Sbjct: 273 LYTSPGSVNVNLPGQALHAHQLSLIHPVSGEIITAIAPMP 312


>UniRef50_D0RPR1 Pseudouridine synthase n=1 Tax=alpha proteobacterium HIMB114
           RepID=D0RPR1_9RICK
          Length = 325

 Score =  269 bits (690), Expect = 4e-71,   Method: Composition-based stats.
 Identities = 70/238 (29%), Positives = 108/238 (45%), Gaps = 29/238 (12%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP----------QAE 58
           P++  L I+++D  I++++KP G++  PG    ++D+++  +               +  
Sbjct: 76  PKKMDLNIIFEDQDIIIIDKPIGMVVHPGAG-NYEDTMVNGLLYHCKNNLSGMNGEDRPG 134

Query: 59  SVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICD 118
            VHR+D  TSG++VVA    A   + +QF E   K+ Y+  V+G   P  G ++  +  +
Sbjct: 135 IVHRIDKDTSGLLVVAKNDQAHAFIAKQFEEHSIKRSYLVFVYGILRPLHGKIETLIGRN 194

Query: 119 WPNRPKQKVCYETGKPAQTEYEVVEYAADN----TARVVLKPITGRSHQLRVHMLALGHP 174
             NR K       GK A T YE +E    N     + V     TGR+HQ+RVHM   G+P
Sbjct: 195 KTNRQKMSADVIRGKDAITNYETLEVFKGNKIPDISLVKCILETGRTHQIRVHMSHKGNP 254

Query: 175 ILGDRFYASP------------EARAMAPRLLLHAEMLTITHPAYGNSMTF--KAPAD 218
           ILGD+ Y               E      R  LHA  L   HP     + F  + P D
Sbjct: 255 ILGDQTYGKKIKKIRGIDQEFEEILKSLKRQALHAHTLGFIHPTTNEEVFFASELPDD 312


>UniRef50_C8WW59 Pseudouridine synthase n=2 Tax=Alicyclobacillus acidocaldarius
           RepID=C8WW59_ALIAD
          Length = 314

 Score =  269 bits (689), Expect = 5e-71,   Method: Composition-based stats.
 Identities = 78/231 (33%), Positives = 116/231 (50%), Gaps = 24/231 (10%)

Query: 9   PQEPWLVIL----------YQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP--- 55
           P+E  L ++          Y+DD ++VV+KP G++  PG        V   + R  P   
Sbjct: 74  PEEEPLELVPDDGVPFVVAYEDDDVIVVDKPRGVVVHPGAGHMRGTLVNGLLARGTPLCT 133

Query: 56  -----QAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGL 110
                +   VHR+D  TSG++V A +  A R L   FR  + +++YVA   G     EG 
Sbjct: 134 LAGALRPGVVHRIDKDTSGLVVFAKSDRAYRALVEAFRAHDVEREYVAIAHGRMPHREGT 193

Query: 111 VDLPLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLA 170
           +D+P+  D  +R +  V  + GK A T +EV+E  A   + + L+  TGR+HQ+RVH+ A
Sbjct: 194 IDMPIARDPADRQRMAV-RQGGKRAVTHFEVLESFA-KYSYLRLRLETGRTHQIRVHLAA 251

Query: 171 LGHPILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
           +GHPI GD  Y  P          LHA  L  THP  G  + F++  P+D 
Sbjct: 252 IGHPIAGDPVYG-PRHTLPIDGQALHARTLGFTHP-DGRRLRFESAVPSDM 300


>UniRef50_Q31HX2 Pseudouridine synthase n=1 Tax=Thiomicrospira crunogena XCL-2
           RepID=Q31HX2_THICR
          Length = 241

 Score =  269 bits (689), Expect = 5e-71,   Method: Composition-based stats.
 Identities = 97/201 (48%), Positives = 137/201 (68%), Gaps = 1/201 (0%)

Query: 16  ILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDMATSGVIVVAL 75
           +LY+DD I+VVNKP+GLLSVPG+  + + +++ ++Q+  P A  VHRLDM TSG++++A 
Sbjct: 29  VLYEDDDIIVVNKPAGLLSVPGKDLDPEMNLLAQVQKHVPTALIVHRLDMDTSGIMILAK 88

Query: 76  TKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYETGKPA 135
            KA+ R L  QF++R  +K Y A  +G PS ++G ++LP+ CDW NRP Q +  + GK A
Sbjct: 89  HKASHRHLSIQFQDRLTEKTYQAICFGKPSTSQGHLNLPMRCDWENRPLQIIDLKQGKAA 148

Query: 136 QTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARAMAPRLLL 195
            T ++ +    DN   V L P+TGRSHQLR+HM  LGHPILGD  YA P++ A + RLLL
Sbjct: 149 STHWK-LTAQYDNAFEVNLTPVTGRSHQLRLHMKMLGHPILGDNLYADPQSFAASKRLLL 207

Query: 196 HAEMLTITHPAYGNSMTFKAP 216
           HA  L +THP    +M F+ P
Sbjct: 208 HAASLKVTHPVTKKTMLFEHP 228


>UniRef50_D1U4S9 Pseudouridine synthase, RluA family n=1 Tax=Desulfovibrio
           aespoeensis Aspo-2 RepID=D1U4S9_9DELT
          Length = 596

 Score =  269 bits (689), Expect = 6e-71,   Method: Composition-based stats.
 Identities = 75/231 (32%), Positives = 112/231 (48%), Gaps = 24/231 (10%)

Query: 13  WLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR-----------DYPQAESVH 61
            L ++++D H+ V++K +GL + P   E     V   + R           D  +   VH
Sbjct: 98  ELEVVFEDAHVAVIDKRAGLTTHPAPGEPGPTLVNHLLHRWPDVASDISGMDRQRPGIVH 157

Query: 62  RLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPN 121
           RLD  TSG++VVALT+     L   F  R  +K Y+A V G P+   G +D P+      
Sbjct: 158 RLDKDTSGLMVVALTEGDRLRLAADFAGRRVRKVYLAVVLGRPAQPAGTIDAPMGRHPSQ 217

Query: 122 RPKQKVCYETGKPAQTEYEVVEYAADN-TARVVLKPITGRSHQLRVHMLALGHPILGDRF 180
           + +  V    G+ A ++Y V+        + V ++  TGR+HQ+RVHM  +GHP+LGD  
Sbjct: 218 KTRMAVVARGGREAVSDYRVLWTGPRGLASLVAVRIHTGRTHQIRVHMAHIGHPLLGDSA 277

Query: 181 YASPEA----------RAMAPRLLLHAEMLTITHPAYGNSMTF--KAPADF 219
           Y   E             +APR +LHA  L+  HPA    +T   + PADF
Sbjct: 278 YGPRENVEWSRRPDRLAGLAPRQMLHAFHLSFRHPATCERVTLWRRPPADF 328


>UniRef50_A8GQ59 Pseudouridine synthase n=15 Tax=Rickettsia RepID=A8GQ59_RICAH
          Length = 329

 Score =  269 bits (688), Expect = 6e-71,   Method: Composition-based stats.
 Identities = 66/233 (28%), Positives = 106/233 (45%), Gaps = 25/233 (10%)

Query: 11  EPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRD---------YPQAESVH 61
              L I+Y+DD ++V+NK +G+   PG    H D+++  +              +   VH
Sbjct: 76  NIALDIIYEDDDLIVINKAAGMTVHPGAGH-HDDTLVNALLYHTKNLSDIGSAARPGIVH 134

Query: 62  RLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPN 121
           RLD  T+G++VVA    A   L  Q  +R+  ++Y A VWG  +P  G++   +      
Sbjct: 135 RLDKDTTGLMVVAKNNKAHMLLANQIEQRQVIRKYKALVWGVINPLAGVIKNNIGRSRVE 194

Query: 122 RPKQKVCYETGKPAQTEYEVVEYAADNT-ARVVLKPITGRSHQLRVHMLALGHPILGDRF 180
           R K  +    GK A T Y+ +E     T + V  +  TGR+HQ+RV +  + H ++GD+ 
Sbjct: 195 RQKMSILKYGGKEAVTHYKTLELFYGGTISMVECRLNTGRTHQIRVQLSHVKHSVVGDQT 254

Query: 181 YASPEARAM------------APRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
           Y + + +                R  LH+  L+ THP     M F    P D 
Sbjct: 255 YGNNDRKIAHSSPALKAKLIDFKRQALHSWYLSFTHPTSNKIMEFSCELPRDM 307


>UniRef50_C0QAZ3 RluD1 n=1 Tax=Desulfobacterium autotrophicum HRM2
           RepID=C0QAZ3_DESAH
          Length = 313

 Score =  269 bits (688), Expect = 6e-71,   Method: Composition-based stats.
 Identities = 78/221 (35%), Positives = 117/221 (52%), Gaps = 14/221 (6%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP-----------QAE 58
           +   L  L++D  I+VVNKP+G++  PG       +++  +   +P           +  
Sbjct: 77  ESISLDFLHEDQWIVVVNKPAGMVVHPGAGNSSG-TLLNALLHHFPSLTDTHCDPPLRGG 135

Query: 59  SVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICD 118
            VHRLD  TSG IVVA +K A   L+++FR R  +K+Y+A   G  +  +G + LP+   
Sbjct: 136 IVHRLDKDTSGTIVVAKSKKAYEFLQKEFRFRRVEKRYIALATGIITETQGRITLPIGRH 195

Query: 119 WPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGD 178
             +R +  V  E  +PA+T + V+   A +T  + +   TGR+HQ+RVH  ALGHP+ GD
Sbjct: 196 PIHRKRMAVNTERARPAETLWRVLGQMAGHT-LLDVGLKTGRTHQIRVHFRALGHPLAGD 254

Query: 179 RFYA-SPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           R Y    +  A APR +LHA  L   HP  G  + F AP  
Sbjct: 255 RVYGFRGKQSARAPRQMLHAGTLGFRHPWSGKRVEFTAPLP 295


>UniRef50_A5GW76 Pseudouridine synthase n=1 Tax=Synechococcus sp. RCC307
           RepID=A5GW76_SYNR3
          Length = 316

 Score =  269 bits (688), Expect = 7e-71,   Method: Composition-based stats.
 Identities = 68/224 (30%), Positives = 112/224 (50%), Gaps = 13/224 (5%)

Query: 6   YNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP---------Q 56
           Y  P+   L +L++D+H++V+NKP+GL   P    +   +++  +    P         +
Sbjct: 80  YLQPEPMDLDVLFEDEHLIVINKPAGLTVHPAPGNKDG-TLVNGLLHHCPDLPGISGKLR 138

Query: 57  AESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLI 116
              VHRLD  T+G IV+A ++ A  +L+ Q ++R   ++Y+A V G P+   G +   + 
Sbjct: 139 PGIVHRLDKDTTGCIVIAKSQQALVKLQVQIQKRVASREYLAVVHGVPAGESGTIVGAIG 198

Query: 117 CDWPNRPKQKVC-YETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPI 175
               +R K  V   + G+ A T + + E   D  + +  K  TGR+HQ+RVH     HP+
Sbjct: 199 RHPVDRKKYAVVSSDNGRYACTHWSLQERLGD-YSLLRFKLDTGRTHQIRVHCAHRNHPV 257

Query: 176 LGDRFYAS-PEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           +GD  Y+   +     P   LHA  L + HP  G  M F+AP  
Sbjct: 258 VGDPTYSRCRKLPIELPGQALHAVQLGLDHPITGERMVFEAPLP 301


>UniRef50_Q49WX8 Pseudouridine synthase n=1 Tax=Staphylococcus saprophyticus subsp.
           saprophyticus ATCC 15305 RepID=Q49WX8_STAS1
          Length = 305

 Score =  268 bits (687), Expect = 8e-71,   Method: Composition-based stats.
 Identities = 64/221 (28%), Positives = 101/221 (45%), Gaps = 13/221 (5%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYPQAESV 60
           P+   L I Y+DD + +V KP G++  P         V   + +           +   V
Sbjct: 76  PENLNLDIYYEDDDVAIVYKPKGMVVHPSAGHYTGTLVNGLMYQMKNLSGINGEIRPGIV 135

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HR+D  TSG+++VA    A R L  Q   +   ++YVA V G      G VD P+  +  
Sbjct: 136 HRIDKDTSGLLMVAKNDVAHRSLVDQLVNKTVTRKYVALVHGKIPHDYGTVDAPIGRNKN 195

Query: 121 NRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRF 180
           +R    V  + GK A T + V+E+  +    +  +  TGR+HQ+RVHM  +G+P++GD  
Sbjct: 196 DRQSMDVV-DDGKEAVTHFNVLEHF-NKYTLIECQLETGRTHQIRVHMKYIGYPLVGDPK 253

Query: 181 YASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
           Y   +   +     LHA ++   HP     +      P DF
Sbjct: 254 YGPKKTLDIG-GQALHAGIIGFEHPVTHEYIEKSTALPEDF 293


>UniRef50_A8ZXZ8 Pseudouridine synthase n=1 Tax=Desulfococcus oleovorans Hxd3
           RepID=A8ZXZ8_DESOH
          Length = 329

 Score =  268 bits (687), Expect = 9e-71,   Method: Composition-based stats.
 Identities = 80/232 (34%), Positives = 115/232 (49%), Gaps = 25/232 (10%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP---------QAES 59
           P+   L +L++D  ++VVNKP GL+  P    E   +++ R+   +P         +   
Sbjct: 77  PEPAPLPLLFEDAFLLVVNKPPGLVVHPAPGHE-GGTLVNRLLHHFPAIGTVGEPDRPGI 135

Query: 60  VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDW 119
           VHRLD  TSG +VVA T AA + L   F+ R+ +K Y+A V+G      G+V LP+    
Sbjct: 136 VHRLDRNTSGALVVAKTAAAHQALSDMFKSRQVRKTYLALVYGQMKSTGGVVTLPIGRHS 195

Query: 120 PNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDR 179
             R K  V     +PA+T ++V +   D  + + L+  TGR+HQ+RVH  AL  P++GD 
Sbjct: 196 LERKKMSVSSPQARPAETRWKVRKAFVD-ASLLELEIHTGRTHQIRVHCTALQRPVVGDP 254

Query: 180 FY--------------ASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPA 217
            Y              AS E    A R +LHA  L   HP  G  M F AP 
Sbjct: 255 TYPCKWTRKRQHFSSRASFELLNAAGRQMLHAWRLEFDHPVTGAPMCFTAPL 306


>UniRef50_P65834 Ribosomal large subunit pseudouridine synthase D n=321
           Tax=Gammaproteobacteria RepID=RLUD_ECOL6
          Length = 326

 Score =  268 bits (686), Expect = 1e-70,   Method: Composition-based stats.
 Identities = 80/235 (34%), Positives = 114/235 (48%), Gaps = 20/235 (8%)

Query: 1   MGMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQ-----RDYP 55
           +  E    PQ+  L I+Y+D+ I+V+NKP  L+  PG        +   +       D P
Sbjct: 71  IEEEARFEPQDIPLDIVYEDEDIIVINKPRDLVVHPGAGNPDGTVLNALLHYYPPIADVP 130

Query: 56  QAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPL 115
           +A  VHRLD  T+G++VVA T  A+  L    + RE  ++Y A   GH + A G VD P+
Sbjct: 131 RAGIVHRLDKDTTGLMVVAKTVPAQTRLVESLQRREITREYEAVAIGHMT-AGGTVDEPI 189

Query: 116 ICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPI 175
                 R    V +  GKPA T Y ++E+   +T R+ L+  TGR+HQ+RVHM  + HP+
Sbjct: 190 SRHPTKRTHMAV-HPMGKPAVTHYRIMEHFRVHT-RLRLRLETGRTHQIRVHMAHITHPL 247

Query: 176 LGDRFYASP------------EARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           +GD  Y                      R  LHA ML + HP  G  M + AP  
Sbjct: 248 VGDPVYGGRPRPPKGASEAFISTLRKFDRQALHATMLRLYHPISGIEMEWHAPIP 302


>UniRef50_D1VS73 Pseudouridine synthase n=1 Tax=Peptoniphilus lacrimalis 315-B
           RepID=D1VS73_9FIRM
          Length = 295

 Score =  267 bits (684), Expect = 2e-70,   Method: Composition-based stats.
 Identities = 62/213 (29%), Positives = 107/213 (50%), Gaps = 11/213 (5%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYPQAESVH 61
           ++    ++Y+D++I V++KP  L+   G        V   + +        D  +   VH
Sbjct: 71  EKIDFNVIYEDEYIAVISKPQDLVVHIGAGNSSGTLVNGLLYKFKNQLSDLDPLRPGIVH 130

Query: 62  RLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPN 121
           RLD  TSG++++A    A   L  QF+  + KK Y+A V G  +P  G++  P+  +  +
Sbjct: 131 RLDKNTSGLMIIAKNNQAHINLVDQFKNSQIKKYYLAIVHGK-TPESGIIAEPIGRNPND 189

Query: 122 RPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFY 181
           R K  V Y+  K A T+Y+ ++   +  + + +  +TGR+HQ+RVHM  +G+P+LGD  Y
Sbjct: 190 RKKMAVVYKNSKQAITKYKKLKEFQE-YSLLNINLLTGRTHQIRVHMAYIGYPVLGDIIY 248

Query: 182 ASPEARAMAPRLLLHAEMLTITHPAYGNSMTFK 214
               +     + +LH+  L   HP     M F 
Sbjct: 249 GRKNSLK-IDKQMLHSYKLIFNHPITNQKMEFT 280


>UniRef50_B8GZR6 Pseudouridine synthase n=2 Tax=Caulobacter vibrioides
           RepID=B8GZR6_CAUCN
          Length = 342

 Score =  267 bits (683), Expect = 3e-70,   Method: Composition-based stats.
 Identities = 72/228 (31%), Positives = 100/228 (43%), Gaps = 22/228 (9%)

Query: 13  WLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR---------DYPQAESVHRL 63
            L ILY+D H++VV+K +G+   P     +   V   +              +   VHRL
Sbjct: 102 PLSILYEDAHLIVVDKAAGMAVHPAPGTYNGTLVNALLHHCGASLSGVGGVARPGIVHRL 161

Query: 64  DMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRP 123
           D  TSGV+V A + AA R L   F   +  + YVA   G P+P  G +   +     +R 
Sbjct: 162 DKDTSGVMVAAKSDAAHRGLSTLFATHDIDRLYVALTRGAPNPPTGTIQTQIGRSPGDRK 221

Query: 124 KQKVCYETGKPAQTEYEVVEYAADN----TARVVLKPITGRSHQLRVHMLALGHPILGDR 179
           K  V    G+ A T Y V            ARV  +  TGR+HQ+RVHM + G P LGD 
Sbjct: 222 KMAVLRAGGREAITHYRVEAAFGPADRPLAARVACRLETGRTHQIRVHMASKGSPCLGDP 281

Query: 180 FYASPE---------ARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
            Y + +           A   R  LHA +L   HP  G ++ F+ P  
Sbjct: 282 VYGAAQPAAAVRERIEAAGLRRQALHAAVLGFVHPITGETLRFETPLP 329


>UniRef50_D0KVM5 Pseudouridine synthase n=11 Tax=Proteobacteria RepID=D0KVM5_HALNC
          Length = 340

 Score =  267 bits (683), Expect = 3e-70,   Method: Composition-based stats.
 Identities = 80/227 (35%), Positives = 113/227 (49%), Gaps = 20/227 (8%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRD-----YPQAESVHRL 63
           PQ+  L I+Y+DD I+V+NK   ++  P         V   +  D      P+A  VHRL
Sbjct: 76  PQDIPLDIIYEDDAIIVLNKSPDIVVHPAAGNPDGTLVNALLFHDPSLVSVPRAGVVHRL 135

Query: 64  DMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRP 123
           D  TSGV+VVA T AA + L      R+ +++Y   V GH   A G VD P+     +R 
Sbjct: 136 DKQTSGVMVVAKTLAAHKILVENLAARKIRREYDTVVMGHVV-AGGTVDAPIGRHPRDRQ 194

Query: 124 KQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYAS 183
           +Q V   TGK A T Y V+++  + T  + ++  TGR+HQ+RVHM  + HP++GD  Y  
Sbjct: 195 RQAV-TATGKRAVTHYRVLQHYGEQT-WLRVQLETGRTHQIRVHMAHIRHPVIGDPVYGG 252

Query: 184 P------------EARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
                        +      R  LHA  LT+ HP  G  M F+AP  
Sbjct: 253 RPRIPPRASTALIDVLRHFERQALHARYLTLAHPVTGTQMRFEAPMP 299


>UniRef50_C7H7W3 Ribosomal large subunit pseudouridine synthase D n=2
           Tax=Faecalibacterium prausnitzii RepID=C7H7W3_9FIRM
          Length = 314

 Score =  266 bits (682), Expect = 3e-70,   Method: Composition-based stats.
 Identities = 67/222 (30%), Positives = 98/222 (44%), Gaps = 13/222 (5%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR---------DYPQAES 59
           PQE  L I+Y+D H++VVNKP G++  P         V   +              +   
Sbjct: 75  PQEIPLDIIYEDAHLLVVNKPKGMVVHPAPGNPDGTLVNALLWHCKGSLSGIGGEIRPGI 134

Query: 60  VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDW 119
           VHR+D  TSG++VVA   A    L +Q      ++ Y   V+G  +  EG V+  L    
Sbjct: 135 VHRVDKDTSGLLVVAKDDATHIGLSQQMAVHSVERAYNTIVYGGFAQDEGFVESNLGRSK 194

Query: 120 PNRPKQKV---CYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPIL 176
            +R K  V        K A T Y+V+E   +    +  +  TGR+HQ+RVHM ++ HP+ 
Sbjct: 195 TDRKKMAVYPASEPHTKYAYTGYKVLERLGE-FTMLECRLKTGRTHQIRVHMASIHHPVA 253

Query: 177 GDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           GD  Y             LHA+ L   HP  G  + F +   
Sbjct: 254 GDPVYGPHNCITSLHGQCLHAKTLGFIHPITGEHLRFDSELP 295


>UniRef50_P54604 Uncharacterized RNA pseudouridine synthase yhcT n=5 Tax=Bacillus
           RepID=YHCT_BACSU
          Length = 302

 Score =  266 bits (682), Expect = 3e-70,   Method: Composition-based stats.
 Identities = 65/217 (29%), Positives = 109/217 (50%), Gaps = 11/217 (5%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP------QAESVHR 62
           P+   L IL++D+H++++NKP+G+ + P    +   ++   I   Y       +   VHR
Sbjct: 78  PEYGELDILFEDNHMLIINKPAGIATHPNEDGQTG-TLANLIAYHYQINGETCKVRHVHR 136

Query: 63  LDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNR 122
           LD  TSG IV A  + A   L +Q  ++  K+ Y A   G     +G ++ P+  D  + 
Sbjct: 137 LDQDTSGAIVFAKHRLAHAILDQQLEKKTLKRTYTAIAEGKLRTKKGTINSPIGRDRSHP 196

Query: 123 PKQKVCYETGKPAQTEYEVVEYAA-DNTARVVLKPITGRSHQLRVHMLALGHPILGDRFY 181
            +++V    G+ A T ++V+   A +  + V L+  TGR+HQ+RVH+ +LGHP+ GD  Y
Sbjct: 197 TRRRV-SPGGQTAVTHFKVMASNAKERLSLVELELETGRTHQIRVHLASLGHPLTGDSLY 255

Query: 182 ASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
                  +  R  LHA  +   HP     +  +AP  
Sbjct: 256 GGGS--KLLNRQALHANKVQAVHPITDELIVAEAPFP 290


>UniRef50_C1FEQ4 Predicted protein n=2 Tax=Micromonas RepID=C1FEQ4_9CHLO
          Length = 357

 Score =  266 bits (682), Expect = 3e-70,   Method: Composition-based stats.
 Identities = 77/250 (30%), Positives = 117/250 (46%), Gaps = 39/250 (15%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR---------------D 53
           P+   L ++++DDH++VVNKP G++  P         V   +                 D
Sbjct: 98  PENIPLDVVFEDDHLVVVNKPPGMVVHPSAGHAGGSLVNALLFHCNERSNRGDDASKMID 157

Query: 54  YPQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDL 113
            P+   VHR+D  TSG++V+A   AA+  L+ QF  R  +++Y+A V G P+   G +D 
Sbjct: 158 VPRLGVVHRIDKGTSGLLVMAKDAAAQAGLQTQFANRSVRRRYLAIVLGTPARESGRIDA 217

Query: 114 PLICDWPNRPKQKVCY-ETGKPAQTEYEVVEY-AADNTARVVLKPITGRSHQLRVHMLAL 171
           P+  D  +R K  +    TG+ A + + V       N + V  +  TGR+HQ+RVH   +
Sbjct: 218 PIGRDPADRLKMAIVRGATGRQAISNFGVRARLVRGNASLVEWQLETGRTHQIRVHAREM 277

Query: 172 GHPILGDRFY--------------------ASPEARAMAPRLLLHAEMLTITHPAYGNSM 211
           GHPI+GD  Y                    A+ E  A   R +LHA  L   HP  G  +
Sbjct: 278 GHPIVGDEAYGGGGSAAAEFLRRDGAMSAAAAREIVAKCARPMLHARSLGFRHPVTGEEI 337

Query: 212 TF--KAPADF 219
           +F  + P DF
Sbjct: 338 SFAVEPPPDF 347


>UniRef50_D1BAB3 Pseudouridine synthase n=1 Tax=Thermanaerovibrio acidaminovorans
           DSM 6589 RepID=D1BAB3_THEAS
          Length = 320

 Score =  266 bits (682), Expect = 3e-70,   Method: Composition-based stats.
 Identities = 77/221 (34%), Positives = 111/221 (50%), Gaps = 14/221 (6%)

Query: 8   PPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP---------QAE 58
            PQ+    ++YQD  ++VV+KP+GL+  P        +++  +   YP         +  
Sbjct: 90  EPQDVPFRVVYQDQDLVVVDKPAGLVVHPAPGHWRG-TLVHGLLYRYPDLMELNGVKRPG 148

Query: 59  SVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICD 118
            VHRLD  TSG++VVA    A   L R F++R   K Y+A   G     EG V LP+  D
Sbjct: 149 IVHRLDATTSGLMVVARNGLAMEGLVRAFKDRRVGKVYLAMAAGTLR-GEGSVSLPIGRD 207

Query: 119 WPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGD 178
             NR +   C   G+ A T Y V+ ++    + V  +  TGR+HQ+RVHM +LGHP++GD
Sbjct: 208 PDNRKRMA-CVPWGREALTRYRVI-WSRGGYSLVACQIKTGRTHQIRVHMRSLGHPLVGD 265

Query: 179 RFYASPEARAM-APRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           R Y  P        R+ LH+  L   HP  G  M+F  P  
Sbjct: 266 RIYGGPCPEGFPLGRVFLHSWRLEFDHPRTGAPMSFICPLP 306


>UniRef50_C8P3R0 Pseudouridine synthase n=1 Tax=Erysipelothrix rhusiopathiae ATCC
           19414 RepID=C8P3R0_ERYRH
          Length = 308

 Score =  266 bits (681), Expect = 4e-70,   Method: Composition-based stats.
 Identities = 72/219 (32%), Positives = 107/219 (48%), Gaps = 11/219 (5%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRD---------YPQAES 59
           P    L I+Y+DD I+VVNKP GL+  P     ++ +++  +              +   
Sbjct: 78  PVPMDLDIVYEDDAILVVNKPKGLIVHPSPSTLNQPTLVHGLLAHTTQLSDLNGELRPGI 137

Query: 60  VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDW 119
           VHR+D  T+G++VVA T  A   L    ++R   ++YVA V          VD P+  D 
Sbjct: 138 VHRIDKDTTGLLVVAKTNEAHEILVEDLKQRLISREYVAIVHHQFKHQSATVDAPIGRDP 197

Query: 120 PNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDR 179
            NR +  V  +  K A T + + E   D  + +  K  TGR+HQ+RVH   + HPI+GD+
Sbjct: 198 KNRQRMAVTDQNSKQAVTHFYLAERFND-FSVLRCKLDTGRTHQIRVHAQYIKHPIVGDQ 256

Query: 180 FYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
            Y S +         LHA+ LT+THP     MTF+A   
Sbjct: 257 TY-SYKNTWETNGQCLHAQKLTLTHPVSKEVMTFEAELP 294


>UniRef50_C5VRN0 Pseudouridine synthase n=1 Tax=Clostridium botulinum D str. 1873
           RepID=C5VRN0_CLOBO
          Length = 302

 Score =  266 bits (681), Expect = 4e-70,   Method: Composition-based stats.
 Identities = 70/220 (31%), Positives = 114/220 (51%), Gaps = 14/220 (6%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ-------AESVH 61
           P++  L I+Y+D+ I+VVNKP G++  P +   H +  ++     Y            V+
Sbjct: 78  PEKMDLDIIYEDNDIIVVNKPKGIVVHPTK--RHLNGTLSNGVLYYFNDKNENSIVRLVN 135

Query: 62  RLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPN 121
           RLDM TSG++++A    +   L R  ++ +  K+Y+A V G+ +   G++D P+      
Sbjct: 136 RLDMDTSGLVLIAKNAYSHMALSRDMQKDDFVKKYLAIVHGNFNEDSGVIDKPIYRVGEG 195

Query: 122 RPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFY 181
             K+ +  E G+ + T ++V+E    N + V L   TGR+HQ+RVH+ ++GHPI GD  Y
Sbjct: 196 TLKR-IIDERGQRSITLFKVIEQYK-NASLVELTLETGRTHQIRVHLSSIGHPIYGDSLY 253

Query: 182 ASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
              E      R  LHA  L I HP  G  +  ++  P D 
Sbjct: 254 G-EEEPQYIDRQALHAYKLQIPHPKDGKILKLESSLPEDM 292


>UniRef50_C6CWL6 Pseudouridine synthase n=2 Tax=Paenibacillus RepID=C6CWL6_PAESJ
          Length = 316

 Score =  265 bits (680), Expect = 5e-70,   Method: Composition-based stats.
 Identities = 74/224 (33%), Positives = 115/224 (51%), Gaps = 16/224 (7%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP------QAESVHR 62
           PQ+  L I+++DD+++VVNKP+G++  P +   + +++   I   +       +   VHR
Sbjct: 84  PQDLPLSIVFEDDYLLVVNKPAGIIVHPTKGH-YTNTLANGIVHHWQVRGERVRFRPVHR 142

Query: 63  LDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNR 122
           LD  TSG++V+A      ++L  Q +     K Y A V+G PSPA+G V  P+  +  + 
Sbjct: 143 LDEDTSGLVVIAKNPYIHQQLSEQLQAGTIMKIYCAYVYGTPSPADGTVGAPIDRNPED- 201

Query: 123 PKQKVCYETGKPAQTEYEVVEYAADN-TARVVLKPITGRSHQLRVHMLALGHPILGDRFY 181
           P  ++    G P+ T Y+          ++V LK  TGR+HQ+RVHM  +G P++GD  Y
Sbjct: 202 PHVRIVTPEGYPSVTHYKTAAVFGGGQASKVRLKLETGRTHQIRVHMKHIGCPLIGDGMY 261

Query: 182 A-----SPEARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PAD 218
                   E    A R  LHAE L +THP       + A  P D
Sbjct: 262 GLQTGKVDEWETAAGRQALHAETLGLTHPMTKEWSEWTAALPPD 305


>UniRef50_D1Y3Y9 Pseudouridine synthase n=1 Tax=Pyramidobacter piscolens W5455
           RepID=D1Y3Y9_9BACT
          Length = 345

 Score =  265 bits (680), Expect = 5e-70,   Method: Composition-based stats.
 Identities = 76/220 (34%), Positives = 115/220 (52%), Gaps = 14/220 (6%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP---------QAESV 60
           Q+    ++Y+DD ++VVNKP+G++  PG       +++  +   YP         +   V
Sbjct: 112 QDMPFDVVYEDDDVIVVNKPAGVVVHPGAGRPDG-TLVNGLMFRYPEIGRIGDSVRPGIV 170

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLD+ TSG++VVA + AA R L   F+  E  K+Y+    G     EG VD P+  D  
Sbjct: 171 HRLDVGTSGLMVVARSDAAFRGLTEAFQAHEVLKEYLGLGVGALKAPEGTVDAPIGRDPR 230

Query: 121 NRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRF 180
           NR K  V ++ G+ A T+Y+V+   A     + ++  TGR+HQ+RVHM ALG  + GD  
Sbjct: 231 NRLKMCVSWD-GRDAVTDYKVLWTRA-RCNLIRVRLHTGRTHQIRVHMRALGCSLDGDTL 288

Query: 181 YA--SPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           Y    P    +  R+ LH+  L   HP  G  + F+AP  
Sbjct: 289 YGPKDPAQHILKDRVFLHSWRLGFRHPVSGERLEFRAPLP 328


>UniRef50_A4WSV2 Pseudouridine synthase n=41 Tax=Alphaproteobacteria
           RepID=A4WSV2_RHOS5
          Length = 349

 Score =  265 bits (680), Expect = 5e-70,   Method: Composition-based stats.
 Identities = 66/250 (26%), Positives = 109/250 (43%), Gaps = 40/250 (16%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR---------DYPQAES 59
           P+   L ++++D  ++V++KP G++  P   +     V   +              +   
Sbjct: 85  PEAIPLSVVWEDADLIVIDKPVGMVVHPAPGQWTGTLVNALLHHCGASLSGIGGEKRPGI 144

Query: 60  VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAE----------- 108
           VHR+D  TSG++VVA T  A + L  QF     +++Y+A V G P P++           
Sbjct: 145 VHRIDKDTSGLLVVAKTDRAHQGLAAQFEAHTVERRYLALVHGVPEPSDPRLRGIRGVSF 204

Query: 109 -----GLVDLPLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADN--TARVVLKPITGRS 161
                  +   +     +R +Q V +E G+ A T   ++E        A V  +  TGR+
Sbjct: 205 EPGGVLRIATGIARHRTDRQRQAVTFEGGRHAVTRARLLERFGTPPAAALVECRLETGRT 264

Query: 162 HQLRVHMLALGHPILGDRFYASPE-------------ARAMAPRLLLHAEMLTITHPAYG 208
           HQ+RVHM  +GH ++GD+ Y                 A    PR  LHA  L   HP  G
Sbjct: 265 HQIRVHMSHVGHGLIGDQTYGGRRKLSAKAVGAEAAQAAEAFPRQALHAATLGFCHPVTG 324

Query: 209 NSMTFKAPAD 218
             ++F++P  
Sbjct: 325 EDLSFESPLP 334


>UniRef50_C6XNC0 Pseudouridine synthase n=1 Tax=Hirschia baltica ATCC 49814
           RepID=C6XNC0_HIRBI
          Length = 369

 Score =  265 bits (680), Expect = 5e-70,   Method: Composition-based stats.
 Identities = 71/265 (26%), Positives = 108/265 (40%), Gaps = 54/265 (20%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR---------DYPQAES 59
           P++  L +L++D+H++++NKP+GL+  P         V   +              +   
Sbjct: 93  PEDIPLDVLFEDEHLIILNKPAGLVVHPAPGSTSGTLVNALLHHCAGQLPGIGGVARPGI 152

Query: 60  VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDW 119
           VHRLD  TSGV+V A T+ A   L   F+    ++ Y+A   G P P  G ++  +    
Sbjct: 153 VHRLDKDTSGVMVAAKTEFAHTGLSSLFQAHFMERAYLAVTRGAPRPLLGKIETRIARST 212

Query: 120 PNRPKQKVCYE-------------------TGKPAQTEYEVVEYAAD--------NTARV 152
            +R K  V  E                    GK A T Y+V+E                 
Sbjct: 213 TDRKKMAVVRESRLSASAEWHGESEEDYEQKGKHAITNYKVLEQFGRIDATSGLPAATLT 272

Query: 153 VLKPITGRSHQLRVHMLALGHPILGDRFYA----------------SPEARAMAPRLLLH 196
             +  TGR+HQ+RVHM  +G P+LGD+ Y                 +  A     R  LH
Sbjct: 273 ECRLETGRTHQIRVHMAHIGAPLLGDQTYGRYRGLKAHGSGPAFETATHACKEFKRQALH 332

Query: 197 AEMLTITHPAYGNSMTFKA--PADF 219
           A +L   HP  G ++ F+   P D 
Sbjct: 333 AAILGFEHPVTGENLRFEVEPPEDM 357


>UniRef50_A0YGE0 Pseudouridine synthase n=1 Tax=marine gamma proteobacterium
           HTCC2143 RepID=A0YGE0_9GAMM
          Length = 221

 Score =  265 bits (680), Expect = 6e-70,   Method: Composition-based stats.
 Identities = 106/203 (52%), Positives = 136/203 (66%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDMATS 68
           P    + IL+ DD +++VNKP+GLLSVPGR   +KD ++TR+QR Y  A  VHRLDM TS
Sbjct: 10  PCTEDVEILFTDDDLLLVNKPAGLLSVPGRHPANKDCLITRVQRQYADARIVHRLDMDTS 69

Query: 69  GVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVC 128
           G++V+AL+  + R L + F ER+  K+Y A V+G       L+DLPL+CDWPNRP+QKV 
Sbjct: 70  GIMVLALSADSHRALSQLFAERKIIKEYEANVYGTIIDDHRLIDLPLLCDWPNRPRQKVD 129

Query: 129 YETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARA 188
           +  GK AQT  E V    D   RV+LKP+TGRSHQLRVH+  +GHPILG  FYA   A +
Sbjct: 130 FHHGKNAQTWVERVSQHPDGWTRVLLKPVTGRSHQLRVHLAEIGHPILGCEFYAHQRAVS 189

Query: 189 MAPRLLLHAEMLTITHPAYGNSM 211
           MA RL LHA  L   HP  G ++
Sbjct: 190 MADRLQLHATKLEFCHPNSGETI 212


>UniRef50_Q01Q94 Pseudouridine synthase n=1 Tax=Candidatus Solibacter usitatus
           Ellin6076 RepID=Q01Q94_SOLUE
          Length = 296

 Score =  265 bits (679), Expect = 7e-70,   Method: Composition-based stats.
 Identities = 68/217 (31%), Positives = 110/217 (50%), Gaps = 11/217 (5%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYPQAESVH 61
           ++  L ILY+D  ++ ++KP+G++   G        V   + R           +   VH
Sbjct: 73  EDIPLRILYEDADVVAIDKPAGMVVHAGAGVHSGTLVNALLHRFATLSGVGGPLRPGIVH 132

Query: 62  RLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPN 121
           RLD  TSGV++VA   AA ++L  QF  RE +K Y+A V G   P  G ++ P+  D  +
Sbjct: 133 RLDRFTSGVLLVAKNDAAHQKLAAQFSGREIEKVYLALVHGTVKPETGRIERPIARDPVH 192

Query: 122 RPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFY 181
           R +       G+ A +EY V+    D    + ++  TGR+HQ+RVH+ ++ HP++GD  Y
Sbjct: 193 RARMTARLAEGRAAWSEYRVLRRFPD-FTLLEVRIGTGRTHQIRVHLASIRHPVVGDTLY 251

Query: 182 ASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
            +P A+ +  R  LHA  +    P  G  M  ++P  
Sbjct: 252 GAP-AQPLLGRYFLHAHRIRFHLP-SGREMLIESPLP 286


>UniRef50_C9RQF0 Pseudouridine synthase, RluA family n=1 Tax=Fibrobacter
           succinogenes subsp. succinogenes S85 RepID=C9RQF0_FIBSS
          Length = 424

 Score =  265 bits (679), Expect = 7e-70,   Method: Composition-based stats.
 Identities = 75/237 (31%), Positives = 110/237 (46%), Gaps = 29/237 (12%)

Query: 8   PPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP----------QA 57
            P++  L I+Y+DD I+V+NKP  L+  PG     K ++   +   +           + 
Sbjct: 72  EPEDIPLNIVYEDDDIVVINKPRNLVVHPGNGV-SKGTLAAALLYHFKENLSTVNGPLRP 130

Query: 58  ESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLIC 117
             VHRLD  T G++VVA   AA R L  Q   R   + Y A VWG P   EG +D P+  
Sbjct: 131 GIVHRLDKDTPGLMVVAKNDAAHRHLAHQLETRTLHRTYNALVWGCPRDLEGTIDAPIGR 190

Query: 118 DWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILG 177
           +  NR K  V  + GK ++T Y V +        + L+  +GR+HQ+RVH    GHP++G
Sbjct: 191 NPKNRLKMAVV-KGGKESRTHY-VAKQFFAIATLLELQLESGRTHQIRVHSRYTGHPVVG 248

Query: 178 DRFYASPEAR----------------AMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           D  Y   +                   +AP  LL A  + + HP     +TFK P +
Sbjct: 249 DPLYDGRDESLNRVPPLMKPVAEKVLEIAPAQLLQAVKIELIHPRTNKKLTFKVPME 305


>UniRef50_B1XN95 Pseudouridine synthase n=1 Tax=Synechococcus sp. PCC 7002
           RepID=B1XN95_SYNP2
          Length = 538

 Score =  265 bits (679), Expect = 7e-70,   Method: Composition-based stats.
 Identities = 86/219 (39%), Positives = 127/219 (57%), Gaps = 12/219 (5%)

Query: 4   ENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRL 63
           ++     E  L I+Y+D  ++ ++KP+GL S+PGR  +  DS  +R++RDY     VHRL
Sbjct: 329 QDILTIPEIPLEIIYEDHSLIAIHKPAGLPSIPGRSSQTYDSAFSRLRRDYQDIFLVHRL 388

Query: 64  DMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRP 123
           D  TSG+++ A     +++L+ QFR R+  K+Y A +       EG++ LPL  D  +RP
Sbjct: 389 DQDTSGILLFAKNAETQQDLQTQFRRRKIHKEYEALLEEKIQRPEGMITLPLWADPGDRP 448

Query: 124 KQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLA---LGHPILGDRF 180
           +QKV  + GKP++T +  ++       R+ LKPITGR+HQLRVH      L +PILGDR 
Sbjct: 449 RQKVDAQRGKPSETYFVKLDSH-----RLKLKPITGRTHQLRVHCAHPNGLNNPILGDRL 503

Query: 181 YASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
           Y +      APRL L A  LT  HP   N  T ++  +F
Sbjct: 504 YGNR----AAPRLHLQATALTFMHPETKNPHTIQSAPEF 538


>UniRef50_D0J9U5 Pseudouridine synthase n=2 Tax=Blattabacterium RepID=D0J9U5_BLASP
          Length = 344

 Score =  265 bits (679), Expect = 8e-70,   Method: Composition-based stats.
 Identities = 65/238 (27%), Positives = 110/238 (46%), Gaps = 31/238 (13%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP------QAESVHRL 63
           +   L ILY+D+ I+V+NK +G++  PG     K +++  I+  +       +   VHR+
Sbjct: 83  ENIPLNILYEDEDILVINKAAGMVVHPG-FGNEKGTLIHGIKYHFKNNHQLYRLGLVHRI 141

Query: 64  DMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRP 123
           D  T+G++V+A  + A++ L +QF  +  +++Y+A VWG+    EG +   +  D  NR 
Sbjct: 142 DKDTTGLLVLAKNEYAQKYLFQQFISKTIQRKYLALVWGNIQKQEGTISGFIGRDPNNRK 201

Query: 124 KQKVCYET---GKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRF 180
           +  +        + + T Y+V+E        V     TG++HQ+RVH   LGHP+  D  
Sbjct: 202 RMTLFQRNFYRSRYSVTHYKVLERFK-YLTYVSCNLETGKTHQIRVHFKYLGHPLFNDST 260

Query: 181 YASPE-----------------ARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
           Y   +                 +  +  R  LHA  L+  HP       F    P DF
Sbjct: 261 YGGDKIFMKKYLSKKSIDFFKDSLNLLKRQALHAGSLSFIHPK-NRKCHFTCSIPEDF 317


>UniRef50_C7LWM1 Pseudouridine synthase, RluA family n=1 Tax=Desulfomicrobium
           baculatum DSM 4028 RepID=C7LWM1_DESBD
          Length = 526

 Score =  265 bits (678), Expect = 1e-69,   Method: Composition-based stats.
 Identities = 80/219 (36%), Positives = 118/219 (53%), Gaps = 11/219 (5%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP--------QAESV 60
           P +  L + + D+ ++VVNK   +   P        +++ R+   +P        +   V
Sbjct: 77  PDDGPLNVFFADEDLVVVNKTPAMTVHPAPSVAEP-TLVHRVAHHFPALLSQSGERPGIV 135

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLD  TSG+IV+AL+++A   L + F  RE  K+Y+A V G P  + G V L L     
Sbjct: 136 HRLDKDTSGLIVLALSESARLSLTQAFASREVYKEYLALVAGVPD-SSGTVSLALGRHPS 194

Query: 121 NRPKQKVCYETGKPAQTEYEVVEYAADN-TARVVLKPITGRSHQLRVHMLALGHPILGDR 179
            + +  V    G+ A+T +E++  AAD   + V ++ +TGR+HQ+RVHM ALGHP+LGD 
Sbjct: 195 IKTRMAVVERGGRAAETRFELLWSAADRSASLVRVRIMTGRTHQIRVHMAALGHPLLGDA 254

Query: 180 FYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
            YA  +  A APR +LHA  L   HP    SM F AP  
Sbjct: 255 VYADKQTAARAPRQMLHAWQLRFEHPRSFESMEFCAPPP 293


>UniRef50_A5EX53 Pseudouridine synthase n=1 Tax=Dichelobacter nodosus VCS1703A
           RepID=A5EX53_DICNV
          Length = 322

 Score =  265 bits (678), Expect = 1e-69,   Method: Composition-based stats.
 Identities = 77/227 (33%), Positives = 117/227 (51%), Gaps = 22/227 (9%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP------QAESVHRL 63
           Q   L ILY DD I+V+NKP+GL+  P  +  H ++++  +   +P      ++  VHRL
Sbjct: 82  QNLPLNILYADDDIIVINKPAGLVVHPA-VGNHDNTLLNALLYHFPQTKHLPRSGIVHRL 140

Query: 64  DMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRP 123
           D  TSG +V+A +  A  +L RQ + R   + Y+A V+G+ +  +  +DLP+     +R 
Sbjct: 141 DKDTSGAMVIAHSARAHTDLVRQLQNRSMGRIYLALVYGYITAGD-TIDLPIGRHAKDRL 199

Query: 124 KQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYAS 183
           K  V    GKPA T Y + E        + ++  TGR+HQ+RVH+    HP++GD+ Y +
Sbjct: 200 KMAV-RPDGKPAITHYRIEERW-QTLTLLRVQLETGRTHQIRVHLSHHRHPLVGDKLYGA 257

Query: 184 ------------PEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
                        +A A  PR  LHA  L + HPA    M F AP  
Sbjct: 258 RPFLASSLTELQRQALAEFPRQALHAVELHLHHPATNEIMRFTAPLP 304


>UniRef50_D1PDP7 Pseudouridine synthase n=1 Tax=Prevotella copri DSM 18205
           RepID=D1PDP7_9BACT
          Length = 556

 Score =  264 bits (677), Expect = 1e-69,   Method: Composition-based stats.
 Identities = 94/220 (42%), Positives = 121/220 (55%), Gaps = 22/220 (10%)

Query: 17  LYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAE---SVHRLDMATSGVIVV 73
           LY+D  + V+ KP GLLSVPG+      SV   ++R Y +A     VHRLDMATSG++++
Sbjct: 342 LYEDRELAVIYKPEGLLSVPGKDAAQP-SVYALMRRKYQEATGPLIVHRLDMATSGLMII 400

Query: 74  ALTKAAERELKRQFREREPKKQYVARVWGHPSPA-----------EGLVDLPLICDWPNR 122
           A T+ A   L+++F     +K+YVA V G    +            G + LPLI D+ +R
Sbjct: 401 AKTEFAYHRLQKEFLNHRVQKKYVAIVCGKDKESCNRILKEAEGGRGYISLPLIADFLDR 460

Query: 123 PKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLA---LGHPILGDR 179
           P+Q V  E GK A TEYEV+E   D   R+ L P TGR+HQLRVH      L  PI+GD 
Sbjct: 461 PRQMVNREQGKEAITEYEVLERIDDTHLRLALYPKTGRTHQLRVHCAHQEGLNAPIIGDP 520

Query: 180 FYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
            Y        A RL LHAE +T  HP  G  MT    ADF
Sbjct: 521 LYG----NEPATRLHLHAEEITFEHPMTGKKMTVTRKADF 556


>UniRef50_Q1Q689 Similar to ribosomal large subunit pseudouridine synthase D n=1
           Tax=Candidatus Kuenenia stuttgartiensis
           RepID=Q1Q689_9BACT
          Length = 335

 Score =  264 bits (677), Expect = 1e-69,   Method: Composition-based stats.
 Identities = 74/235 (31%), Positives = 113/235 (48%), Gaps = 24/235 (10%)

Query: 3   MENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVM-------TRIQRDYP 55
            E    P++  L I+Y+DD++M++NKP  ++  P         V           Q + P
Sbjct: 80  EETKITPEDIPLNIIYEDDYLMLINKPYDMVVHPAGGHPSGTLVNAVTFYCQNLSQINGP 139

Query: 56  -QAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLP 114
            +A  VHRLD  TSGV++V  + A    +  QF +R  KK+Y A V G  +     +++P
Sbjct: 140 LKAGIVHRLDRDTSGVMLVIKSDAVHSHIAMQFEKRLVKKEYFAVVEGEVAFDSNEINMP 199

Query: 115 LICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHP 174
           +     +R K  V  +TGK A + YEV+E        V + P TGR+HQ+RVHM A+GHP
Sbjct: 200 IGRHRVDRQKMAVRRDTGKNATSVYEVIERFR-GYTLVKIMPKTGRTHQIRVHMQAIGHP 258

Query: 175 ILGDRFYAS---------------PEARAMAPRLLLHAEMLTITHPAYGNSMTFK 214
           ++ D  Y+                P+  ++  R  LHA  +   HP     M F+
Sbjct: 259 VVADEMYSKYNACFRSDLLGKERAPDEGSIIERQALHAHRIEFFHPILNKQMAFQ 313


>UniRef50_C1ZGS9 Pseudouridine synthase n=1 Tax=Planctomyces limnophilus DSM 3776
           RepID=C1ZGS9_PLALI
          Length = 345

 Score =  264 bits (676), Expect = 1e-69,   Method: Composition-based stats.
 Identities = 83/239 (34%), Positives = 115/239 (48%), Gaps = 30/239 (12%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDY---------PQAES 59
           P++  L ILY D+++ V+NK + ++  PGR   ++ ++   +Q  +          +A  
Sbjct: 86  PEDIPLDILYDDEYLCVINKTANMIVHPGRG-NYRGTLAGALQFHFDSLSDVAGQYRAGI 144

Query: 60  VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDW 119
           VHRLD  TSGV+VVA      + L RQF ER  +K+Y A VWG        V+  +   +
Sbjct: 145 VHRLDRDTSGVLVVAKDNTVHQHLSRQFEERSVEKEYHAIVWGEMQFDADYVETYVRVSF 204

Query: 120 PNRPKQKVCY--ETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILG 177
            NR +  VC   +  + A T YEV +        V L+P TGR+HQLRVHM  LGHPI+ 
Sbjct: 205 RNRERMMVCPPGDNARQAATFYEVQQRFR-GFTYVKLQPQTGRTHQLRVHMHHLGHPIIA 263

Query: 178 DRFYASPE---------------ARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
           DR Y                      +  R  LHA  L   HP     M F+A  PADF
Sbjct: 264 DRLYEGKTCVKLSDILPETPEEADETLIDRQALHARRLAFNHPVTKKRMVFEAPLPADF 322


>UniRef50_UPI0001C42CC7 hypothetical protein BpOF4_01845 n=1 Tax=Bacillus pseudofirmus OF4
           RepID=UPI0001C42CC7
          Length = 322

 Score =  264 bits (675), Expect = 2e-69,   Method: Composition-based stats.
 Identities = 73/232 (31%), Positives = 113/232 (48%), Gaps = 22/232 (9%)

Query: 3   MENYNPPQE---------PWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRD 53
           +E Y PP+            L I Y+DDH++V+NKP G+ ++P R  EH    +      
Sbjct: 85  VEVYVPPEPKNESLRPECIPLDIHYEDDHLLVINKPQGMPTIPSR--EHPSRTLANAVMG 142

Query: 54  YPQAES-------VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSP 106
           Y ++         V+RLD  TSG++VVA    A  +L +  R  + K+ Y+A   G   P
Sbjct: 143 YYESHHIPFTFHAVNRLDRDTSGLLVVAKHGLAHDQLSKGQRAGKLKRYYLALAEGFVQP 202

Query: 107 AEGLVDLPLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRV 166
            EG +  P+     +  ++ V  + G+ A T Y+V+       + V +   TGR+HQ+RV
Sbjct: 203 REGTIHAPIKRRPSSIIERMVAAD-GQEAITHYKVI-NDNQAYSEVEINLETGRTHQIRV 260

Query: 167 HMLALGHPILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           H   LGHP+LGD  Y    +  +  R  LH + + + HP  G  + F AP  
Sbjct: 261 HFAHLGHPLLGDDLYGG--SIELLARQALHCQRVELIHPFTGKHLHFSAPLP 310


>UniRef50_C5BU65 Pseudouridine synthase for 23S rRNA and tRNAphe n=1
           Tax=Teredinibacter turnerae T7901 RepID=C5BU65_TERTT
          Length = 208

 Score =  263 bits (674), Expect = 3e-69,   Method: Composition-based stats.
 Identities = 100/208 (48%), Positives = 126/208 (60%), Gaps = 3/208 (1%)

Query: 13  WLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDMATSGVIV 72
            L I+YQDDHI+ +NKP+GLL+VPG      D+   ++   +P +  VHRLDMATSG+++
Sbjct: 3   DLAIIYQDDHIIAINKPAGLLTVPG--LATPDNAFDQLVHQHPNSRVVHRLDMATSGLVI 60

Query: 73  VALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYETG 132
              +  +     R F +R+  K Y A V G  +   G + LPLICDWPNRPKQKV  E G
Sbjct: 61  FPQSHESLVRFGRLFEQRKMTKTYTATVAGIVAEDRGEITLPLICDWPNRPKQKVDLEQG 120

Query: 133 KPAQTEYEVVEYAAD-NTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARAMAP 191
           K A T+Y+V+E   D  T R+ L PITGRSHQLRVHM  LGHPILGD FYA    +  + 
Sbjct: 121 KHAHTQYKVLERRLDLQTTRIELTPITGRSHQLRVHMQQLGHPILGDAFYAPDAIQQASD 180

Query: 192 RLLLHAEMLTITHPAYGNSMTFKAPADF 219
           RLLLHA  L   HP      +     DF
Sbjct: 181 RLLLHATTLEFVHPFTQCPTSIHCEPDF 208


>UniRef50_Q6MEC0 Pseudouridine synthase n=1 Tax=Candidatus Protochlamydia
           amoebophila UWE25 RepID=Q6MEC0_PARUW
          Length = 318

 Score =  263 bits (674), Expect = 3e-69,   Method: Composition-based stats.
 Identities = 73/225 (32%), Positives = 110/225 (48%), Gaps = 14/225 (6%)

Query: 4   ENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRI--------QRDYP 55
           E+   P+   L ILY+D+H++V+NKP+G++  P         V   +          D  
Sbjct: 77  ESNLMPENIPLSILYEDEHLLVINKPAGMVVHPAPGNWSGTFVNALLYYCQKLPLLPDTI 136

Query: 56  QAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPL 115
           +   VHRLD  TSG++V A T   +++L   F  R+  K Y+A   G P  A+G +  P+
Sbjct: 137 RPGIVHRLDKGTSGLLVAAKTLETQQKLIELFASRKVYKAYLAICIGRP--ADGEIQAPI 194

Query: 116 ICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPI 175
                +R +  V   TGKPA +  + + ++ D  + V ++  TGR+HQ+RVHM   G PI
Sbjct: 195 GRHPIHRKQMAVI-PTGKPAISFCKTLGWS-DKLSFVQIEIATGRTHQIRVHMKYRGSPI 252

Query: 176 LGDRFYASPEARAM--APRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           LGD  Y           P  LLHA +L   HP    ++ F  P  
Sbjct: 253 LGDPLYGQISLNQYYSVPHQLLHAAVLRFQHPISLENLEFCTPPP 297


>UniRef50_B7GEZ0 Pseudouridine synthase n=7 Tax=Bacillaceae RepID=B7GEZ0_ANOFW
          Length = 315

 Score =  263 bits (674), Expect = 3e-69,   Method: Composition-based stats.
 Identities = 70/216 (32%), Positives = 111/216 (51%), Gaps = 10/216 (4%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVP---GRLEEHKDSVMTRIQRD--YPQAESVHRL 63
           P    L I+++DDH++VVNK + +   P   G+     ++V    Q +  Y +   +HRL
Sbjct: 91  PTYVPLHIVFEDDHVLVVNKRAHMDVHPTQPGQTNTLANAVAFHFQCEGIYSKVRHIHRL 150

Query: 64  DMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRP 123
           D  TSGVI+ A    A   L +   +R  ++ Y+A V G+    +G ++ P+  D  +  
Sbjct: 151 DRDTSGVILFAKHALAGAILDQYLAKRTIRRTYIALVHGYVKQKKGTIEAPIGRDRHHPT 210

Query: 124 KQKVCYETGKPAQTEYEVVEYAAD-NTARVVLKPITGRSHQLRVHMLALGHPILGDRFYA 182
           +++V  +TG  A T YE ++Y    + + V L   TGR+HQ+RVHM  +GHP++GD  Y 
Sbjct: 211 RRRV-SKTGDTAITHYERLQYDKQKHVSLVRLTLDTGRTHQIRVHMSYIGHPLVGDTLYG 269

Query: 183 SPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
               +    R  LHA  L+  HP     +T  A  D
Sbjct: 270 G---KPWIDRQALHAFSLSFLHPFTEELITCSALPD 302


>UniRef50_B1ZYX0 Pseudouridine synthase n=4 Tax=Verrucomicrobia RepID=B1ZYX0_OPITP
          Length = 311

 Score =  263 bits (673), Expect = 3e-69,   Method: Composition-based stats.
 Identities = 84/221 (38%), Positives = 122/221 (55%), Gaps = 15/221 (6%)

Query: 11  EPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP----------QAESV 60
           +  L +L++D H++ VNK +G++  PG +   +D+++  +               +   V
Sbjct: 77  DIPLTVLFEDKHMLAVNKAAGMVVHPG-VATSEDTLVHALLAHCAGSLSGIGGVERPGIV 135

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLD  T+GVIVVA T AA R L  QF  R  KK+YVA V G P    G +D  +     
Sbjct: 136 HRLDKETTGVIVVAKTDAAHRALADQFATRTLKKEYVALVAGVPRLLSGSIDRAIARHPV 195

Query: 121 NRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRF 180
           +R +  V  E G+PA+T++E+VE   D  A V  +  TGR+HQ+RVH+ +LGHPILGD  
Sbjct: 196 HRHRMTV-GEGGRPARTDWELVEAFGDIGALVRCRIFTGRTHQIRVHLKSLGHPILGDAL 254

Query: 181 YASPEARAMAP---RLLLHAEMLTITHPAYGNSMTFKAPAD 218
           Y       +A    R++LHAE L +THP  G  +  +AP  
Sbjct: 255 YGWKPEPRLATQPARVMLHAEHLVLTHPISGKELDLRAPLP 295


>UniRef50_D1W0M0 Pseudouridine synthase n=1 Tax=Prevotella timonensis CRIS 5C-B1
           RepID=D1W0M0_9BACT
          Length = 566

 Score =  263 bits (673), Expect = 4e-69,   Method: Composition-based stats.
 Identities = 95/218 (43%), Positives = 126/218 (57%), Gaps = 16/218 (7%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP---QAESVHRLDMA 66
           Q   L ++Y+DD ++VV+KP+G+LSVPGR +    SV + ++   P   +  SVHRLDMA
Sbjct: 347 QHSQLHVVYEDDALIVVDKPAGILSVPGRSQR--PSVYSILRSQMPSSVELFSVHRLDMA 404

Query: 67  TSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQK 126
           TSG++++A      R L+RQFR    +K+Y+A + G  S  EG+V LPL  D  +RP+Q 
Sbjct: 405 TSGLLILAKNSVVYRHLQRQFRTHHIQKEYIAILEGALSQREGVVTLPLRPDPFDRPRQV 464

Query: 127 VCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLA---LGHPILGDRFYAS 183
           V +E GK A T Y V+      T  V L P TGR+HQLR+H      L  PILGD  Y  
Sbjct: 465 VDWEHGKKAVTSYRVLNVRHGKT-WVALFPETGRTHQLRMHCAHAEGLNCPILGDPLYGH 523

Query: 184 PEARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
                 A RL LHA  +T  HP  G  +T  A  PADF
Sbjct: 524 -----HANRLYLHATSITFEHPISGQLLTLHAQPPADF 556


>UniRef50_B9YI75 Pseudouridine synthase, RluA family n=1 Tax='Nostoc azollae' 0708
           RepID=B9YI75_ANAAZ
          Length = 329

 Score =  263 bits (673), Expect = 4e-69,   Method: Composition-based stats.
 Identities = 62/220 (28%), Positives = 109/220 (49%), Gaps = 12/220 (5%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYPQAESVH 61
           ++  L ILY+D+ ++++NKP+GL+  P         V   +             +   VH
Sbjct: 95  EDIPLDILYEDEQLLILNKPAGLVVHPAPGHLDGTLVNALLAHCANLPGIGGVQRPGIVH 154

Query: 62  RLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPN 121
           RLD  T+G I +A T  A + L+ Q + +  +++Y+  V+G P    G+++LP+     +
Sbjct: 155 RLDKDTTGAIAIAKTDIAYQHLQAQLQAKTARREYLGVVYGVPKTESGIINLPISRHPQD 214

Query: 122 RPKQKVCY--ETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDR 179
           R K  +    + G+ A T +++ E  + N   +  +  TGR+HQ+RVH   +GHPI+GD 
Sbjct: 215 RKKMAIVPTEQGGRTAITHWQIRERLS-NYTLIHFQLETGRTHQIRVHSAKIGHPIVGDS 273

Query: 180 FYASPEARAM-APRLLLHAEMLTITHPAYGNSMTFKAPAD 218
            Y +  +  +      LHA  L + HP  G+ +   A   
Sbjct: 274 VYGAGRSVGVNLAGHALHAWQLKLQHPISGDWIQVTASPP 313


>UniRef50_Q5PAD0 Pseudouridine synthase n=5 Tax=Anaplasma RepID=Q5PAD0_ANAMM
          Length = 327

 Score =  262 bits (672), Expect = 4e-69,   Method: Composition-based stats.
 Identities = 70/231 (30%), Positives = 110/231 (47%), Gaps = 20/231 (8%)

Query: 8   PPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEH---KDSVMTRIQRDYP------QAE 58
           P  +  L ++Y+D  ++V++K   +   PG   EH    ++++ R            +  
Sbjct: 76  PNYDIDLKVVYEDHDVIVIDKDPYIAVHPGNGIEHHTITNALLARFGAGLQSVGSSSRPG 135

Query: 59  SVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICD 118
            VHRLD  TSG++V A T+ A   L  +   +  KK+Y+A  WG P P  G++   +   
Sbjct: 136 IVHRLDKDTSGLMVAAKTENAYYRLSEELANQGFKKEYLAVAWGIPCPKRGVIHTNIRVK 195

Query: 119 WPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGD 178
             +    +     GKPA+TEYEV +   +  + +     TGR+HQ+RVHM  +GH I+GD
Sbjct: 196 RSDITMMEAANSGGKPAKTEYEVEQELGEVASLIRCTLHTGRTHQIRVHMSHIGHSIVGD 255

Query: 179 RFYAS----------PEARAMAPRLLLHAEMLTITHPAYGNSMTFKA-PAD 218
           + Y            P       R  LHA +L   HP+ G  + F + PAD
Sbjct: 256 QKYGKNCKKCMRSGVPPDVKNFRRQALHASLLGFRHPSTGKYIEFTSKPAD 306


>UniRef50_C0QPR5 Pseudouridine synthase n=4 Tax=Hydrogenothermaceae
           RepID=C0QPR5_PERMH
          Length = 319

 Score =  262 bits (671), Expect = 6e-69,   Method: Composition-based stats.
 Identities = 67/225 (29%), Positives = 109/225 (48%), Gaps = 19/225 (8%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYPQAESV 60
           P+   + IL++D+ I VV KP+G++  P         V   +             +A  V
Sbjct: 80  PENIPVDILFEDEDIAVVYKPAGMVVHPSPGHTSGTLVNALLYHFRNISEYGGKERAGIV 139

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLD  T+G++++A ++ A +EL++QF+ER   K+Y+A V G      G +DLP+     
Sbjct: 140 HRLDKDTAGLMIIAKSEFAHKELQKQFQERTVDKRYIAVVTGIVQNDHGFIDLPIGRSIY 199

Query: 121 NRPKQKVCYETGKPAQTEYEVVEYA-ADNTARVVLKPITGRSHQLRVHMLALGHPILGDR 179
           NR K        + A TEY V   +  +N   V +K  TGR+HQ+RVH  A+GHP+  D+
Sbjct: 200 NRKKMGTEATNLRDALTEYWVKNRSEKENLTVVDIKLHTGRTHQIRVHFSAIGHPLFNDK 259

Query: 180 FYASPEARAMAPRL----------LLHAEMLTITHPAYGNSMTFK 214
            Y   +++  + ++           L A  +   HP  G  +   
Sbjct: 260 VYGFKKSQLRSEKMRSISDQTLYHALLAYRIAFDHPRTGEKIDIT 304


>UniRef50_C8S0A2 Pseudouridine synthase n=1 Tax=Rhodobacter sp. SW2
           RepID=C8S0A2_9RHOB
          Length = 356

 Score =  262 bits (671), Expect = 6e-69,   Method: Composition-based stats.
 Identities = 70/250 (28%), Positives = 105/250 (42%), Gaps = 40/250 (16%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR---------DYPQAES 59
           P++  L ++++D  ++VV+KP G++  P         V   +              +   
Sbjct: 94  PEDIPLTVVWEDADLIVVDKPVGMVVHPAPGSYTGTLVNALLHHCGDTLSGVGGAKRPGI 153

Query: 60  VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPA-------EGL-- 110
           VHR+D  TSG++VVA T  A   L  QF      + Y+A V G P+ A        G+  
Sbjct: 154 VHRIDKDTSGLLVVAKTDRAHHGLAAQFEAHSVTRHYIALVHGAPNAADPRLRGIRGVSF 213

Query: 111 -------VDLPLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADN--TARVVLKPITGRS 161
                  +   L     +R +Q V +++G+ A T   V+E        A V     TGR+
Sbjct: 214 EPGGIVCIATNLARHKTDRQRQAVLFDSGRHAVTRVRVLESYGTPPVAALVECWLETGRT 273

Query: 162 HQLRVHMLALGHPILGDRFYASP-------------EARAMAPRLLLHAEMLTITHPAYG 208
           HQ+RVHM   GH +LGD+ Y                +A    PR  LHA  L   HP  G
Sbjct: 274 HQIRVHMSHAGHALLGDQTYGGRRKVAPKAVGEAVAQAANDFPRQALHAASLGFVHPVSG 333

Query: 209 NSMTFKAPAD 218
             + F +P  
Sbjct: 334 EELLFTSPLP 343


>UniRef50_Q5E092 Pseudouridine synthase n=3 Tax=Aliivibrio RepID=Q5E092_VIBF1
          Length = 576

 Score =  262 bits (670), Expect = 7e-69,   Method: Composition-based stats.
 Identities = 89/218 (40%), Positives = 125/218 (57%), Gaps = 14/218 (6%)

Query: 8   PPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAE---SVHRLD 64
           P     L I+Y+DD +++VNKP   LSV G+     DSV  RIQ  YP A     VHRLD
Sbjct: 367 PSYGKELEIVYEDDVLVIVNKPVEFLSVSGKY--ISDSVHARIQARYPNATGPLIVHRLD 424

Query: 65  MATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPK 124
           M+TSG++V+ LT  + +++++QF ER  +K+Y A + G+     G ++LPL  D  +RP+
Sbjct: 425 MSTSGLLVLTLTAESNKQVQKQFIERTVEKRYTALLEGNIETDNGTINLPLTGDMEDRPR 484

Query: 125 QKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLA---LGHPILGDRFY 181
           Q V +++G+ A+T Y+V+      T +V L P TGR+HQLRVH      L  PI+GD  Y
Sbjct: 485 QMVNHKSGRKAETHYQVIAQEGKRT-KVHLYPHTGRTHQLRVHCAHQAGLNTPIVGDDLY 543

Query: 182 ASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
                   A RL LHA  L   HP    ++ F  P DF
Sbjct: 544 G-----FKADRLHLHAGYLKFKHPTTNETVEFSCPEDF 576


>UniRef50_A8UMR7 Pseudouridine synthase n=1 Tax=Flavobacteriales bacterium ALC-1
           RepID=A8UMR7_9FLAO
          Length = 561

 Score =  262 bits (670), Expect = 8e-69,   Method: Composition-based stats.
 Identities = 98/215 (45%), Positives = 133/215 (61%), Gaps = 14/215 (6%)

Query: 11  EPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAE---SVHRLDMAT 67
              L I+Y+DD ++V+NKP   LSVPG+    KDSV+TR+Q   P A     +HRLDM+T
Sbjct: 355 NGELEIIYEDDFLVVLNKPHEFLSVPGK--TIKDSVLTRMQNYLPDATGPLLLHRLDMST 412

Query: 68  SGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKV 127
           SG+++VA  +   + L++QF +R  KK+YVA + G   P+EG +DLPL  D  NRP+Q V
Sbjct: 413 SGLLLVAKNERTHKNLQKQFIKRIVKKRYVALLNGKLEPSEGTIDLPLRVDLNNRPRQLV 472

Query: 128 CYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLA---LGHPILGDRFYASP 184
           C E GK A+T+YEV+E   +N  R+   PITGR+HQLRVH      L  PI+GD  Y + 
Sbjct: 473 CDEHGKLAKTKYEVIE-IKNNKTRIHFYPITGRTHQLRVHAAHYKGLNMPIIGDDLYGTA 531

Query: 185 EARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
                + RL LHAEML+  HP     ++F   A F
Sbjct: 532 -----SNRLHLHAEMLSFEHPVKREWVSFSCKAPF 561


>UniRef50_Q13E92 Pseudouridine synthase n=28 Tax=Alphaproteobacteria
           RepID=Q13E92_RHOPS
          Length = 426

 Score =  262 bits (670), Expect = 8e-69,   Method: Composition-based stats.
 Identities = 73/242 (30%), Positives = 112/242 (46%), Gaps = 34/242 (14%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR---------DYPQAESV 60
           +   L I+++DD I+V++KP GL+  P    E    V   I              +   V
Sbjct: 174 EAIALEIVHEDDDIIVIDKPRGLVVHPAAGHETGTLVNALIAHCGESLSGIGGVRRPGIV 233

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFRER----EPKKQYVARVWGHPSPAEGLVDLPLI 116
           HRLD  T+G++V A    A + L  QF +     E ++ Y A VWG P+   G +D P+ 
Sbjct: 234 HRLDKDTTGLMVAAKNDRAHQSLSAQFADHGRTGELRRGYYAFVWGAPNRIRGTIDAPID 293

Query: 117 CDWPNRPKQKVCYETGKPAQTEYEVVEYAADN-----TARVVLKPITGRSHQLRVHMLAL 171
                R K  V  + G+ A T +EV+E           + +  +  TGR+HQ+RVH+  +
Sbjct: 294 RHPHAREKMAV-RDGGREAITHWEVLETFTGRSGGEIVSLIACQLETGRTHQIRVHLAHI 352

Query: 172 GHPILGDRFYA-------------SPEARAMAPRLLLHAEMLTITHPAYGNSMTFKA--P 216
           GHP+LGD  Y              +  A     R  LHA +L + HP+ G  + +++  P
Sbjct: 353 GHPLLGDDVYGPHFKTKASQLRPDARAALTDLGRQALHAYLLVLEHPSTGEVVAWESGLP 412

Query: 217 AD 218
           AD
Sbjct: 413 AD 414


>UniRef50_Q7UHX8 Pseudouridine synthase n=1 Tax=Rhodopirellula baltica
           RepID=Q7UHX8_RHOBA
          Length = 334

 Score =  261 bits (669), Expect = 1e-68,   Method: Composition-based stats.
 Identities = 79/246 (32%), Positives = 106/246 (43%), Gaps = 37/246 (15%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYPQAESV 60
           P+   L ILY+DD ++V+NKP+G++  P R             R           +   V
Sbjct: 74  PENIPLDILYEDDGLVVINKPAGMVVHPARGNWTGTLTSALAFRFQSLSDVGGPTRPGIV 133

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLD  TSGVIVVA   A    L  Q+ +R  +K+Y A  +G        +   +     
Sbjct: 134 HRLDRDTSGVIVVAKNNAVHLNLAAQWHDRLVQKEYTAITFGRLDRDRDWIHASIGRHPY 193

Query: 121 NRPKQKVC--YETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGD 178
            R KQ +   + T K A T YEVVE       RV ++P TGR+HQ+RVH+  +G PIL D
Sbjct: 194 QRDKQAIREGHATSKTASTFYEVVERHG-RVTRVDVRPKTGRTHQIRVHLAHIGCPILCD 252

Query: 179 RFYAS--------------------------PEARAMAPRLLLHAEMLTITHPAYGNSMT 212
           R Y                                 +  R  LHA+ LT T+P  G  MT
Sbjct: 253 RLYGGHSELSRSQIRRLAGTEVATPGVKPTPEGEEILLSRQALHAKALTFTNPQTGKEMT 312

Query: 213 FKAPAD 218
             AP  
Sbjct: 313 LTAPLP 318


>UniRef50_B0VJ94 Pseudouridine synthase n=1 Tax=Candidatus Cloacamonas
           acidaminovorans RepID=B0VJ94_9BACT
          Length = 351

 Score =  261 bits (668), Expect = 1e-68,   Method: Composition-based stats.
 Identities = 68/236 (28%), Positives = 103/236 (43%), Gaps = 28/236 (11%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR---------DYPQAES 59
           PQ+  L ++Y+D+++ ++NK +G++  PG        V   + R         ++ +   
Sbjct: 84  PQDIPLDVVYEDEYLAIINKKAGMIVHPGFGNPEGTLVNAILYRFGENLSSGKEFNRPGI 143

Query: 60  VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDW 119
           VHRLD  TSG+I++A       +L   F  RE KK Y A   G P P +G ++  L    
Sbjct: 144 VHRLDRGTSGLIIIAKNDLTHAKLSDMFARREIKKTYFAITTGIPEPEKGEIETYLARSN 203

Query: 120 PNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDR 179
            N P+       G+ A T Y+ ++      A V + P TGR HQ+RVH   + +PILGD 
Sbjct: 204 KN-PRTICVTNEGRYALTHYKTIKTW-HYFALVEINPATGRMHQIRVHFAHIRYPILGDL 261

Query: 180 FYASPEARA-----------------MAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
            Y S                         R  LH+  L   HP  G  ++  AP  
Sbjct: 262 LYNSRRYVQSLVPQNMKKKVTELLVNHLRRQALHSWKLEFFHPITGYPISVSAPIP 317


>UniRef50_C7QW59 Pseudouridine synthase n=5 Tax=Cyanobacteria RepID=C7QW59_CYAP0
          Length = 551

 Score =  261 bits (668), Expect = 1e-68,   Method: Composition-based stats.
 Identities = 89/224 (39%), Positives = 126/224 (56%), Gaps = 10/224 (4%)

Query: 2   GMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQA---E 58
           G+ N     +  + ++Y+D  I+ ++KPSGLLSVPGR  E  DSV+TR+Q   P A    
Sbjct: 332 GLGNNQSFFKSEIKVIYEDQWIIAIDKPSGLLSVPGRYFETFDSVLTRLQNSLPDAQELR 391

Query: 59  SVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICD 118
           +VHRLD  TSG++++A  +   R L +QF +R+ +K Y A + G     EG++ LPL  D
Sbjct: 392 TVHRLDQDTSGILLLARDRYTHRHLSQQFAQRKVEKIYEAILAGSVMMNEGVIQLPLWGD 451

Query: 119 WPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHM---LALGHPI 175
             NRP QKV +E GKP+ T+++V+    +N  R+   P+TGR+HQ+RVH      LG  I
Sbjct: 452 PNNRPYQKVDWELGKPSITQFKVI-TTQENLTRIQFIPLTGRTHQIRVHAVDTQGLGSVI 510

Query: 176 LGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
           LGD  Y      A   RL LHA  L   HP    ++       F
Sbjct: 511 LGDYLYGC---NAGVSRLHLHARELKFEHPQQQKTVHLYLETPF 551


>UniRef50_Q1CZL9 Pseudouridine synthase n=5 Tax=Proteobacteria RepID=Q1CZL9_MYXXD
          Length = 559

 Score =  260 bits (667), Expect = 2e-68,   Method: Composition-based stats.
 Identities = 91/212 (42%), Positives = 123/212 (58%), Gaps = 12/212 (5%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAE---SVHRLDMATSGV 70
           L I+++D+ ++VV KP GLLSVP +    +DSV+ R++   P+A      HRLD+ TSG+
Sbjct: 354 LDIVFEDEWLVVVEKPEGLLSVPAKDVSVEDSVLARLRARAPEAAGTMLAHRLDLDTSGL 413

Query: 71  IVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYE 130
           +V A        L+RQF  RE  K+Y A V G+     G +D P+  D  +RP+Q     
Sbjct: 414 LVAAKDARTYAALQRQFAGREVHKRYAAWVEGNVQGERGTIDFPMRVDLDDRPRQIHDPV 473

Query: 131 TGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLA---LGHPILGDRFYASPEAR 187
            GKPA TE+ V+E +   T +V L P+TGR+HQLRVH      LG PI+GDR Y  P   
Sbjct: 474 HGKPAVTEWHVLERSHGRT-KVALFPLTGRTHQLRVHAAHPLGLGAPIVGDRLYGHP--- 529

Query: 188 AMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
              PRL LHAE L+  HP  G  +T + PA F
Sbjct: 530 --GPRLHLHAEALSFQHPVTGQRLTLERPAPF 559


>UniRef50_A3RGY8 Pseudouridine synthase n=1 Tax=uncultured bacterium
           RepID=A3RGY8_9BACT
          Length = 353

 Score =  260 bits (667), Expect = 2e-68,   Method: Composition-based stats.
 Identities = 78/227 (34%), Positives = 116/227 (51%), Gaps = 19/227 (8%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR-----DYPQAESVHRL 63
           P+   L ++++DD I+V+NKP  L+  P         +   +       D P+A  VHRL
Sbjct: 105 PEPMPLEVIFEDDAILVLNKPPKLVVHPAAGHWSGTLLNGLLAYAPTLIDVPRAGIVHRL 164

Query: 64  DMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRP 123
           D  TSG++VVA T AA+ +L RQ + R   ++Y A V G PS   G++D  +  D  N  
Sbjct: 165 DADTSGLMVVAKTLAAQTDLVRQLQSRTVTREYWALVLGVPSQ-RGVIDAAIGRDPRNPL 223

Query: 124 KQKVC-YETGKPAQTEYEVV---EYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDR 179
           + KV   E  KPA+T Y  +   + A  + + +  +  TGR+HQ+RVH+  +GHP++GD 
Sbjct: 224 RFKVSTTEAAKPARTHYATLDSTKNAGADISWLACRLETGRTHQIRVHLEHVGHPLIGDP 283

Query: 180 FY-------ASPEARAM-APRLLLHAEMLTITHPAYGNSMT-FKAPA 217
            Y         P AR     R  LHA  L + HP     +  F +PA
Sbjct: 284 VYRRRLPPRGEPAARWKEFDRQALHACRLALDHPVSRQRLNWFHSPA 330


>UniRef50_C6LL16 Pseudouridine synthase n=3 Tax=Clostridiales RepID=C6LL16_9FIRM
          Length = 313

 Score =  260 bits (667), Expect = 2e-68,   Method: Composition-based stats.
 Identities = 64/217 (29%), Positives = 106/217 (48%), Gaps = 11/217 (5%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES------VHR 62
           P    L I+Y+D+ ++V++KP+ +   P  +    +++   +   Y           + R
Sbjct: 80  PVPMKLDIVYEDEDLLVIDKPADMPVHPS-IHNFDNTLANGLAYYYESRGEAFVYRCITR 138

Query: 63  LDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNR 122
           LD  T+G+++VA    +   L    + RE  ++Y+A V G  + AEG VD P+     + 
Sbjct: 139 LDRDTTGLLLVAKNMLSGAFLAEMGKRREIHREYLAIVTGK-TEAEGTVDAPIARVEGSV 197

Query: 123 PKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYA 182
            ++ V ++ G+ A T Y  +EY  D  + V LK  TGR+HQ+RVHM  +GHP+ GD  Y 
Sbjct: 198 LERCVDFQRGERAVTHYRTLEY-RDGYSLVRLKLETGRTHQIRVHMKYIGHPLTGDFLYN 256

Query: 183 SPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
                 +     LH+  L   HP  G  M F +   +
Sbjct: 257 PD--YRLMDHQALHSHYLAFRHPITGERMEFTSQPPW 291


>UniRef50_C0QV86 Pseudouridine synthase n=2 Tax=Brachyspira RepID=C0QV86_BRAHW
          Length = 329

 Score =  260 bits (667), Expect = 2e-68,   Method: Composition-based stats.
 Identities = 61/214 (28%), Positives = 104/214 (48%), Gaps = 12/214 (5%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSV--PGRLEEHKDSVMTRIQRDY------PQAESV 60
           P+   L ILY+D +++V+NKP+G+     P  +     + +    +D+       +A  +
Sbjct: 104 PENIDLDILYEDKYLLVINKPAGMSVHCSPSEMSGTLVNALLYKIKDFDFVGNKERAGII 163

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLD  TSG++++         ++ QF+ R  KK Y A V G        ++LP+     
Sbjct: 164 HRLDKDTSGLMIIGKNANIVSSIQEQFKNRTIKKIYHAIVVGVLKDNYIEINLPIGRHHV 223

Query: 121 NRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRF 180
            R K  V  E GK A T  +V++    +T  + +   TGR+HQ+RVH    G P+ GD+ 
Sbjct: 224 YRKKMTV-REDGKEALTHIKVLKRFNSHT-LIEINLKTGRTHQIRVHSSYKGFPVAGDKI 281

Query: 181 YASPEARAMAPRLLLHAEMLTITHPAYGNSMTFK 214
           Y+   ++     L+L A+ +   HP     + F+
Sbjct: 282 YSKSFSKYSG--LMLVAKKIEFMHPITKELLDFE 313


>UniRef50_C6J6E3 Pseudouridine synthase n=2 Tax=Bacillales RepID=C6J6E3_9BACL
          Length = 321

 Score =  260 bits (667), Expect = 2e-68,   Method: Composition-based stats.
 Identities = 77/233 (33%), Positives = 117/233 (50%), Gaps = 25/233 (10%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQA------ESVHR 62
           P+     I+Y+D+ +++VNK +GL+  P     +  ++   +   + +         VHR
Sbjct: 80  PEPIPFDIVYEDEALLIVNKAAGLIVHPTHGH-YTGTLANGVVYYWQEKGEKFRFRPVHR 138

Query: 63  LDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNR 122
           LD  TSG+I +A      + +  Q    E  K+Y A V G P+  EG +D P+  D P  
Sbjct: 139 LDQETSGLIAIAKNAYVHQHISEQLIAGEVTKKYTALVHGCPAVPEGTIDGPIDRD-PAE 197

Query: 123 PKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYA 182
           P +++   +G P+ T Y+V E   D  ARV L+  TGR+HQ+RVHM ++GHP++GD+FY 
Sbjct: 198 PHRRIVTPSGYPSLTYYKVAEAYGDG-ARVELRLGTGRTHQIRVHMTSIGHPLIGDKFYG 256

Query: 183 SP--------------EARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
            P                 A   R  LHA  L   HP  G ++TFK+  P D 
Sbjct: 257 MPGLAELPAPARERIARLDAAIGRQALHASELGFRHPLTGEALTFKSELPEDM 309


>UniRef50_C1F7V3 Pseudouridine synthase n=1 Tax=Acidobacterium capsulatum ATCC 51196
           RepID=C1F7V3_ACIC5
          Length = 355

 Score =  260 bits (667), Expect = 2e-68,   Method: Composition-based stats.
 Identities = 69/244 (28%), Positives = 105/244 (43%), Gaps = 35/244 (14%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLE-----EHKDSVMTRIQRDYP--------Q 56
           ++  L I+Y+D  ++VVNKP+G++   G             V   + R           +
Sbjct: 100 EDIPLDIIYEDKDLIVVNKPAGMMVHAGSGATDSARNRGTLVNALLGRQEKLSKTGGDLR 159

Query: 57  AESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLI 116
              VHRLD  TSG+I+VA   AA + L   F +RE  K Y+A V GH +   G ++  + 
Sbjct: 160 PGIVHRLDKETSGLIIVARNDAAHQRLAEMFSQREIHKTYLALVHGHIAEDRGTINAAIA 219

Query: 117 CDW-PNRPKQKVCYETGKPAQTEYEV---VEYAADNTARVVLKPITGRSHQLRVHMLALG 172
            D            E  + A + Y V   +E        V ++  TGR+HQ+RVH+ ++G
Sbjct: 220 RDVIRRTRMTTRRTEGARTAISHYRVQRRIETRWGKFTLVSVRIETGRTHQIRVHLSSIG 279

Query: 173 HPILGDRFYASPEARAM------------------APRLLLHAEMLTITHPAYGNSMTFK 214
           HP++GD  Y +P    +                   PR  LHA  L   HP     +  +
Sbjct: 280 HPVVGDTHYGAPTTIVLPVANRARRKQLPAPEGLSLPRNFLHAAELKFPHPRSEKPLHLE 339

Query: 215 APAD 218
           AP  
Sbjct: 340 APLP 343


>UniRef50_B5YKV0 Pseudouridine synthase n=1 Tax=Thermodesulfovibrio yellowstonii DSM
           11347 RepID=B5YKV0_THEYD
          Length = 315

 Score =  260 bits (667), Expect = 2e-68,   Method: Composition-based stats.
 Identities = 69/226 (30%), Positives = 115/226 (50%), Gaps = 20/226 (8%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP----------QAE 58
           PQ   + ++Y+DD+++V++KP+G++  P     H D  +      +           +  
Sbjct: 77  PQNIPIQVIYKDDYLIVLSKPAGMVVYP--CAGHPDGTLMNALAYHVKKLANVGAPFRPG 134

Query: 59  SVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICD 118
            VHRLD  TSGV+VVAL      +L   F++RE KK+Y+A V+G      G +  P+   
Sbjct: 135 IVHRLDKDTSGVMVVALDDETYYKLVEAFKKREIKKEYLALVYGQLR-GSGKITTPVGRA 193

Query: 119 WPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGD 178
             +R K  +  +  K A TE+EV++    N   + +K +TGR+HQ+RVH  ++GHP++GD
Sbjct: 194 IYDRKKMSIKSKKAKEAITEWEVIKNFK-NYTFLKVKILTGRTHQIRVHFSSIGHPVIGD 252

Query: 179 RFYASP------EARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           + Y           +    R +LHA  + + HP     + F+A   
Sbjct: 253 KTYGRKTYIEIGNKKIPVSRQMLHAHKIELIHPITEKLLQFEASLP 298


>UniRef50_C0ZH07 Pseudouridine synthase n=1 Tax=Brevibacillus brevis NBRC 100599
           RepID=C0ZH07_BREBN
          Length = 306

 Score =  260 bits (666), Expect = 2e-68,   Method: Composition-based stats.
 Identities = 63/214 (29%), Positives = 106/214 (49%), Gaps = 11/214 (5%)

Query: 11  EPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQA------ESVHRLD 64
           +  L I Y+D+ +MV+ KP+GL+  P        ++   +   + +        +V+RLD
Sbjct: 78  DMPLSIRYEDEDLMVIAKPAGLVVHPT-GNHPSGTLANGMIAYWKKRGENRKFRAVNRLD 136

Query: 65  MATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPK 124
             TSG+++VA  + A  +  R  + R  ++ Y A V G     +G ++ P+     +   
Sbjct: 137 KDTSGLMIVAKNQWAHEQFSRMQQIRTLQRTYRAIVQGIVESDDGTINTPIGLAENSFIT 196

Query: 125 QKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASP 184
           ++V    G+ A T Y V+    +  + V +K  TGR+HQ+RVHM + GHP+ GD  Y   
Sbjct: 197 RQV-RPDGQTAVTHYRVLAR-GEGMSFVEVKLETGRTHQIRVHMSSEGHPLAGDDLYGG- 253

Query: 185 EARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
             R    R  LHA  L+  HP  G +M+++ P  
Sbjct: 254 -EREHIGRQALHAWGLSFVHPRSGLAMSWEEPLP 286


>UniRef50_Q1J0S8 Pseudouridine synthase n=7 Tax=Deinococci RepID=Q1J0S8_DEIGD
          Length = 341

 Score =  260 bits (666), Expect = 2e-68,   Method: Composition-based stats.
 Identities = 78/227 (34%), Positives = 108/227 (47%), Gaps = 19/227 (8%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR------------DYPQ 56
           P+   L +LY+D+H++ VNKP G+++ P         V   + R            D  +
Sbjct: 92  PEAVPLDVLYEDEHLIAVNKPPGMVTHPAPGVTSGTLVNALLGRLTLPEQPGAVGPDGYR 151

Query: 57  AESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGL-VDLPL 115
              VHRLD  TSGVIVVA T  A   L   F++R   K Y+A   G       + V+ P+
Sbjct: 152 PGIVHRLDKDTSGVIVVAKTVEAHARLAAAFKDRSTHKTYLAIAAGMWKAQGPVSVNAPV 211

Query: 116 ICDWPNRPKQKVCYETGKPAQTEYEVVEYAADN----TARVVLKPITGRSHQLRVHMLAL 171
                 R +  V     + AQT +  +    D      A V  +P TGR+HQ+RVH+  L
Sbjct: 212 GRHPTARQRMTVGGVGPREAQTLFTPLATHPDGHGRTLALVRAQPHTGRTHQIRVHLAHL 271

Query: 172 GHPILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           G PILGD  Y    A A+ PR  LHA+ LT+ HP  G ++   AP  
Sbjct: 272 GSPILGDAVYG--RASAVMPRHALHAQFLTLPHPVTGETLHLHAPVP 316


>UniRef50_C6JBH1 Pseudouridine synthase n=1 Tax=Ruminococcus sp. 5_1_39BFAA
           RepID=C6JBH1_9FIRM
          Length = 299

 Score =  260 bits (666), Expect = 2e-68,   Method: Composition-based stats.
 Identities = 64/214 (29%), Positives = 106/214 (49%), Gaps = 11/214 (5%)

Query: 11  EPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES------VHRLD 64
           +  L I+Y+D+ I+V+NKP+ +   P     +++++   I   + +         ++RLD
Sbjct: 78  KMDLNIIYEDEDILVINKPADMPVHPSAG-NYENTLANGIAWYFAEKGEDFVYRCINRLD 136

Query: 65  MATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPK 124
             T+G +++A    +   L  Q ++R+  + Y+A V G   P  G ++ P+     +   
Sbjct: 137 RDTTGALILAKNPLSAAILSVQMKKRQILRTYLALVDG-LLPDSGTINAPIARMEGSVIT 195

Query: 125 QKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASP 184
           ++V + TG+ A T YE +  A    +   L   TGR+HQ+RVHM  +GHP+ GD  Y   
Sbjct: 196 REVNFGTGESAITHYERLA-AGKEYSLAELHLETGRTHQIRVHMKYIGHPLPGDYLYNPD 254

Query: 185 EARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
             R    R  LH+  L  THP  G  M F AP  
Sbjct: 255 YRR--INRQPLHSYQLEFTHPTTGKVMLFTAPLP 286


>UniRef50_A6NQQ9 Pseudouridine synthase n=1 Tax=Bacteroides capillosus ATCC 29799
           RepID=A6NQQ9_9BACE
          Length = 300

 Score =  260 bits (666), Expect = 2e-68,   Method: Composition-based stats.
 Identities = 77/216 (35%), Positives = 112/216 (51%), Gaps = 10/216 (4%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQA------ESVHR 62
           P    L I+YQD  ++V+NK  G+   PG    + D++   +   Y +         VHR
Sbjct: 79  PAPGPLDIVYQDQDVLVLNKAPGVAVHPGPGH-YSDTIGNFLMDYYRKQGILADFHPVHR 137

Query: 63  LDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNR 122
           LD  TSG+++VAL   A+  LK Q      ++ Y+A   G P+P  G++D P+     + 
Sbjct: 138 LDRGTSGLLLVALHGHAQEVLKEQLHSPSFRRVYLAVCEGAPNPPSGVIDAPIGRLEGSV 197

Query: 123 PKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYA 182
             + V    G+ A T Y  +    D  A V L+  TGR+HQ+RVHM  LGHP+ GD  Y 
Sbjct: 198 LARTV-RPDGQRAVTHYRTLRTVNDR-ALVRLELETGRTHQIRVHMAHLGHPLTGDFLYG 255

Query: 183 SPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           + E +++ PR  LHA  L+ THP  G +M F AP  
Sbjct: 256 T-EDQSLIPRPALHAAELSFTHPITGKTMAFTAPLP 290


>UniRef50_O67638 Uncharacterized RNA pseudouridine synthase aq_1758 n=3
           Tax=Aquificaceae RepID=Y1758_AQUAE
          Length = 316

 Score =  260 bits (666), Expect = 2e-68,   Method: Composition-based stats.
 Identities = 74/222 (33%), Positives = 104/222 (46%), Gaps = 17/222 (7%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYPQAESV 60
           P+   + I+Y+D+ I VV KP GL+  P         V   +             +   V
Sbjct: 77  PENIPINIIYEDEDIAVVEKPCGLVVHPSPGYTSGTLVNALLYHIKDLSSIGGVERPGIV 136

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLD  T+GV+V+A    A R L RQF+ER+ +K Y   V G      G +D P+     
Sbjct: 137 HRLDKETAGVMVIAKNNTAHRNLVRQFQERKTEKFYKVLVKGLVKKDYGAIDTPIARHPV 196

Query: 121 NRPKQKVCYETGKPAQTEYEVVEYAADN-TARVVLKPITGRSHQLRVHMLALGHPILGDR 179
           +R +  V  E GK A TEY V++         + +K  TGR+HQ+RVH  ++GHP+LGDR
Sbjct: 197 DRKRFWVRKE-GKEALTEYWVLKRYEKYEITLLKVKIHTGRTHQIRVHFASIGHPVLGDR 255

Query: 180 FYASPEARAMAPRL-------LLHAEMLTITHPAYGNSMTFK 214
            Y    +      L       +L A  L   HP  G  M F+
Sbjct: 256 TYGFKSSSVPKELLSLMGECNMLIAYHLGFYHPTKGEWMVFE 297


>UniRef50_C1A885 Pseudouridine synthase n=1 Tax=Gemmatimonas aurantiaca T-27
           RepID=C1A885_GEMAT
          Length = 329

 Score =  260 bits (666), Expect = 2e-68,   Method: Composition-based stats.
 Identities = 67/221 (30%), Positives = 113/221 (51%), Gaps = 14/221 (6%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP--------QAESVH 61
           ++  L ++Y+D+H++VV+K +G++  P         V   + R  P        +A  VH
Sbjct: 79  EQIPLDVVYEDEHLLVVDKAAGMVVHPAPGNWTGTLVNALLGRGEPLAEGGGEDRAGLVH 138

Query: 62  RLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPN 121
           RLD  TSG++VVA + AA R L      R+  ++Y A  WGH +     V+ P+  D  +
Sbjct: 139 RLDKDTSGLLVVAKSDAAHRTLSSALAARQVTRRYAAVCWGHLAEERITVEKPIARDPRD 198

Query: 122 RPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFY 181
           R +  +  ++GK ++T++  +    D+   +     TGR+HQ+RVH+ + GHP++GD  Y
Sbjct: 199 RTRMAIV-QSGKASRTDFTRLARF-DSVDLLRAHLHTGRTHQIRVHLASTGHPVVGDDTY 256

Query: 182 ASPEARAMA----PRLLLHAEMLTITHPAYGNSMTFKAPAD 218
                R +A     R  LHA  L   HP  G+ +  ++P  
Sbjct: 257 GGGGGRRLALLPPRRHFLHAAWLRFRHPISGDLIDLRSPLP 297


>UniRef50_B0JGC2 Pseudouridine synthase n=2 Tax=Microcystis aeruginosa
           RepID=B0JGC2_MICAN
          Length = 501

 Score =  260 bits (665), Expect = 3e-68,   Method: Composition-based stats.
 Identities = 83/207 (40%), Positives = 121/207 (58%), Gaps = 6/207 (2%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDMATSGVIVV 73
           L I+Y+D+ I+ +NKP+GLLSV GR ++ +D+V+ R +R       VHRLD  TSG++++
Sbjct: 300 LEIIYEDEGIIAINKPAGLLSVAGRYQDSQDAVVNRFRRQGKNLIPVHRLDRETSGILLL 359

Query: 74  ALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYETGK 133
           A +    R L +QF+ RE +K Y A +        G++DLPL  +  NRP Q V ++ GK
Sbjct: 360 AKSLDIYRCLSQQFQRREVEKIYEAILSEIIERESGIIDLPLWGNPQNRPYQTVDWQRGK 419

Query: 134 PAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHM-LALGHPILGDRFYASPEARAMAPR 192
            +QT ++VV     N +R+   P TGR+HQ+RVH    LG  ILGDR Y   ++     R
Sbjct: 420 ASQTYFKVVGKEG-NYSRLEFIPYTGRTHQIRVHSQQGLGIGILGDRLYNGKQS----DR 474

Query: 193 LLLHAEMLTITHPAYGNSMTFKAPADF 219
           L LHA+ L+  HP   N +    P  F
Sbjct: 475 LHLHAKQLSFRHPQTENKLDLIIPTPF 501


>UniRef50_Q26D11 Pseudouridine synthase n=2 Tax=Flavobacteria RepID=Q26D11_9BACT
          Length = 561

 Score =  260 bits (665), Expect = 3e-68,   Method: Composition-based stats.
 Identities = 94/220 (42%), Positives = 126/220 (57%), Gaps = 14/220 (6%)

Query: 6   YNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAE---SVHR 62
            NP  +  + ++Y+DD I++VNKP   LSVPG+    KDSV +R++  YP A     VHR
Sbjct: 350 INPGIDKTMEVIYEDDAIIIVNKPEEFLSVPGK--TIKDSVYSRLKELYPDATGPILVHR 407

Query: 63  LDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNR 122
           LDM+TSG++V          ++ QF  R   K+YVA + G     EG+++LPL  D  NR
Sbjct: 408 LDMSTSGILVATKNLEYYHFIQEQFINRTISKRYVALLNGVLENNEGMIELPLRVDLDNR 467

Query: 123 PKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLA---LGHPILGDR 179
           P Q VCYE GK A+T+Y+V+E     T  V   PITGR+HQLRVH      L  PI+GD 
Sbjct: 468 PTQLVCYEYGKSARTKYQVLERREKET-LVHFYPITGRTHQLRVHAAHASGLNAPIVGDD 526

Query: 180 FYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
            Y +        RL LHAE +   HP    +++FKAP  F
Sbjct: 527 LYGTAT-----NRLHLHAEFIKFIHPITHKTVSFKAPVPF 561


>UniRef50_Q0F3G2 Possible pseudouridine synthase n=1 Tax=Mariprofundus ferrooxydans
           PV-1 RepID=Q0F3G2_9PROT
          Length = 325

 Score =  260 bits (665), Expect = 3e-68,   Method: Composition-based stats.
 Identities = 73/231 (31%), Positives = 113/231 (48%), Gaps = 22/231 (9%)

Query: 8   PPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYPQAES 59
            P++  L IL++D+H++V+NKP+G++  P    +H   V   +             +   
Sbjct: 82  EPEDLPLDILFEDEHLIVLNKPAGIVVHPSHGHDHGTLVHALLHHCKTLPGINGVERPGI 141

Query: 60  VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDW 119
           VHRLD  TSG +V+A ++   + L   F E    +QY+A   G PS     ++LP+    
Sbjct: 142 VHRLDKDTSGSLVIAKSEVVHQRLSEMFAEHNLNRQYIAWCRGVPSWRVKCIELPIGRHP 201

Query: 120 PNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDR 179
             R K  V  ++G+ + T+  V E+     +++ L   TGR+HQ+RVHM     P+LGD 
Sbjct: 202 HQRQKMAV-TDSGRESITDAAV-EHIFGPFSQMRLTLHTGRTHQIRVHMAHENLPVLGDP 259

Query: 180 FYA------------SPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
            YA            +  A A   R  LHAE+L   HP  G  M+F+AP  
Sbjct: 260 VYARSYHPGREIPEPARHAIATLSRQALHAELLEFDHPISGEPMSFRAPLP 310


>UniRef50_B7VRG6 Pseudouridine synthase n=4 Tax=Vibrionales RepID=B7VRG6_VIBSL
          Length = 563

 Score =  259 bits (664), Expect = 4e-68,   Method: Composition-based stats.
 Identities = 93/219 (42%), Positives = 127/219 (57%), Gaps = 14/219 (6%)

Query: 7   NPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAE---SVHRL 63
           NP       I+Y+DD I+VVNKP   LSVPG+  E  DSV TRI+  YP A     +HRL
Sbjct: 353 NPAVGKSFDIVYEDDEIVVVNKPEEFLSVPGKFIE--DSVYTRIKARYPDATGPLIIHRL 410

Query: 64  DMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRP 123
           DM+TSG++++ALT  + + +++QF +R  +K+Y A + G      G + LPL  D  +RP
Sbjct: 411 DMSTSGLLILALTAESNKHIQKQFIDRTVEKRYTALLDGEIDGKSGDISLPLRGDITDRP 470

Query: 124 KQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLA---LGHPILGDRF 180
           +Q VC+E G+ A+T +E V      T +V L P TGR+HQLRVH      LG PI GD  
Sbjct: 471 RQLVCHEHGRNAETHWEAVSTNNGKT-KVHLYPKTGRTHQLRVHCAHPSGLGVPIRGDDL 529

Query: 181 YASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
           Y          RL LHA  L + HP  G  + F+ P++F
Sbjct: 530 YGYKR-----ERLHLHAGYLKLIHPTTGEWIEFEVPSEF 563


>UniRef50_Q2S3B7 Pseudouridine synthase n=1 Tax=Salinibacter ruber DSM 13855
           RepID=Q2S3B7_SALRD
          Length = 349

 Score =  259 bits (664), Expect = 4e-68,   Method: Composition-based stats.
 Identities = 77/263 (29%), Positives = 113/263 (42%), Gaps = 53/263 (20%)

Query: 8   PPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------------- 52
            P+   L ++++ D ++VVNKP+G++  P         V   +                 
Sbjct: 68  EPEAIPLDVVHEGDDLLVVNKPAGMVVHPAPGHRSGTLVHALLHHVDGGEVAADDERDEV 127

Query: 53  -----------------DYP--QAESVHRLDMATSGVIVVALTKAAERELKRQFREREPK 93
                            D+P  +   VHRLD  TSG++VVA    A + L  QF+     
Sbjct: 128 SEDEVGLSLVNALPQSPDHPVVRPGIVHRLDKGTSGLLVVAKRGRAHQPLAEQFKAHTVD 187

Query: 94  KQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYET-GKPAQTEYEVVEYAADNTARV 152
           ++Y A VWG  +P++G ++  +  D  +R +  V  E  GK A+T YE VE  A +T+ V
Sbjct: 188 RRYRAIVWGRFAPSDGTIEGAIGRDPHHRQRMAVVPEDEGKWARTHYETVETHA-HTSVV 246

Query: 153 VLKPITGRSHQLRVHMLALGHPILGDRFYASPEARA----------------MAPRLLLH 196
             +  TGR+HQ+RVH  A GHP+LGD  Y     R                   P   LH
Sbjct: 247 EFELETGRTHQIRVHARAQGHPLLGDPKYGGQRVRYGTQSGTRRTFYDQLFETLPHPALH 306

Query: 197 AEMLTITHPAYGNSMTFKA-PAD 218
           A  L   HP     + F+A P  
Sbjct: 307 AYRLGFDHPTTEERLRFEADPPP 329


>UniRef50_Q0F1Z5 Pseudouridine synthase n=1 Tax=Mariprofundus ferrooxydans PV-1
           RepID=Q0F1Z5_9PROT
          Length = 579

 Score =  259 bits (663), Expect = 5e-68,   Method: Composition-based stats.
 Identities = 90/214 (42%), Positives = 127/214 (59%), Gaps = 16/214 (7%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ---AESVHRLDMATSGV 70
           + I+Y+DD ++VVNKP+GL+S PGR  E ++S+ +R+ + YPQ      VHRLDM TSG+
Sbjct: 374 IEIVYEDDQLLVVNKPAGLMSTPGR--EIEESLFSRLAQRYPQIPELTLVHRLDMDTSGL 431

Query: 71  IVVALTKAAERELKRQFREREPKKQYVARVWGHPS--PAEGLVDLPLICDWPNRPKQKVC 128
           ++VA      + L++QF ER  +K Y A +       P +G ++LPL  D  +RP+Q VC
Sbjct: 432 LLVAKDLRTHKRLQKQFIERSVEKCYEAVLVKRLPAQPDQGRIELPLRVDLDDRPRQMVC 491

Query: 129 YETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLA---LGHPILGDRFYASPE 185
           Y+ GKPA T ++++    + T R+   P TGR+HQLRVH      L   I+GD  Y  P 
Sbjct: 492 YQHGKPATTRWQIIARENNRT-RIWFYPETGRTHQLRVHASHRDGLNAAIVGDGLYGLP- 549

Query: 186 ARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
               A RL+LHA  L  THP     M F+ PA F
Sbjct: 550 ----AERLMLHARRLCFTHPVSREPMVFELPAPF 579


>UniRef50_Q4FN11 Pseudouridine synthase n=4 Tax=Bacteria RepID=Q4FN11_PELUB
          Length = 326

 Score =  259 bits (663), Expect = 5e-68,   Method: Composition-based stats.
 Identities = 67/240 (27%), Positives = 102/240 (42%), Gaps = 31/240 (12%)

Query: 4   ENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQ---------RDY 54
           E    P    L I+Y+DD ++++NKP+G++  PG     +  V   +           D 
Sbjct: 72  EASLKPYNFKLQIVYEDDDLLIINKPAGIIMHPGAGNYDETIVNALMHYNKDSLSTIGDE 131

Query: 55  PQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLP 114
            +   VHR+D  TSG+IV+A        L  QF E    + Y   +WG   P+ G +D  
Sbjct: 132 LRPGIVHRIDKDTSGLIVIAKNNETHENLSHQFSEHTITRVYQLLIWGKLRPSSGKIDTF 191

Query: 115 LICDWPNRPKQKVCYETGKPAQTEYEVVEYAAD----NTARVVLKPITGRSHQLRVHMLA 170
           +     NR   +V    GK A T Y+ +E   +      + V  +  TGR+HQ+RVHM  
Sbjct: 192 ITRSSKNRQMMEVSNSKGKRAITNYKTIEIFENDKTPTLSLVECRLETGRTHQIRVHMTH 251

Query: 171 LGHPILGDRFYASPEARAM---------------APRLLLHAEMLTITHPAYGNSMTFKA 215
           +G+ I+GD      + +                   R  LHA+ L   HP     M F +
Sbjct: 252 MGNSIMGD---GKYKKKYKKLKNIDTNLENLIYKLDRQFLHAQTLGFIHPRTNEEMVFTS 308


>UniRef50_Q2GGY1 Pseudouridine synthase n=13 Tax=Rickettsiales RepID=Q2GGY1_EHRCR
          Length = 337

 Score =  259 bits (663), Expect = 5e-68,   Method: Composition-based stats.
 Identities = 62/240 (25%), Positives = 113/240 (47%), Gaps = 26/240 (10%)

Query: 4   ENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP-------- 55
           +   P     + ++Y+D  I+++NK  G+   PG    + ++++  +   Y         
Sbjct: 86  DTITPNHYIPISVVYEDHDIIIINKAPGITVHPGAGTNN-NTLVNALVAHYGNSLSHVGK 144

Query: 56  --QAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDL 113
             +   +HRLD  TSG++V+A  + +   L     +++ KK+Y+A VWG P+P    +  
Sbjct: 145 ATRPGIIHRLDKDTSGLMVIAKNEKSYYFLSDLLLKKQIKKEYLAVVWGLPNPKSNTIKN 204

Query: 114 PLICDWPNRPKQKVCY--ETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLAL 171
            +     N+    V +    GK A TEY+  +  ++  + +  +  TGR+HQ+RVHM  +
Sbjct: 205 YICVKPNNKQMMTVTHLPHKGKLAITEYQTQKSFSNIASLIKCRIHTGRTHQIRVHMSYI 264

Query: 172 GHPILGDRFYASPEARAM-----------APRLLLHAEMLTITHPAYGNSMTFKA--PAD 218
           G+ I+GD+ Y    ++++             R  LHA  L  THP     + F +  P D
Sbjct: 265 GNSIIGDQKYGKNNSKSVKYAKQSTIINTLKRQALHAYKLGFTHPTSNTYIEFHSYIPND 324


>UniRef50_D2R7T3 Pseudouridine synthase, RluA family n=1 Tax=Pirellula staleyi DSM
           6068 RepID=D2R7T3_9PLAN
          Length = 355

 Score =  259 bits (663), Expect = 6e-68,   Method: Composition-based stats.
 Identities = 72/232 (31%), Positives = 105/232 (45%), Gaps = 23/232 (9%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRI--------QRDYPQAESV 60
           P++  L IL++D+H++ VNKP G++  P R                         +   V
Sbjct: 110 PEKIPLDILFEDEHLIAVNKPPGMVVHPARGHWSGTLTSALAFHFQQLSTVGGQHRPGIV 169

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLD  TSGVI+VA T      L  QF +R   K+Y A   G P     +V  P+     
Sbjct: 170 HRLDRDTSGVIIVAKTDPVHFSLAAQFADRTTAKEYFAITAGVPDRDRDVVSQPIGIHPF 229

Query: 121 NRPKQKVC--YETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGD 178
           +R K  +   + T + A+T + V+E  A + A V   P TGR+HQ+RVH+  +  P+L D
Sbjct: 230 HREKMAIRPGHSTSRDAETMFHVLERFAQHAA-VECLPKTGRTHQIRVHLAHVRTPVLCD 288

Query: 179 RFYAS------------PEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           + Y                   +  R  LHA  L+I HP  G  +T +AP  
Sbjct: 289 KLYGGRAEITQGELVRDGSTEVVLNRQALHARKLSINHPKTGERLTIEAPLP 340


>UniRef50_C0ZCK6 Pseudouridine synthase n=1 Tax=Brevibacillus brevis NBRC 100599
           RepID=C0ZCK6_BREBN
          Length = 302

 Score =  259 bits (662), Expect = 6e-68,   Method: Composition-based stats.
 Identities = 74/211 (35%), Positives = 102/211 (48%), Gaps = 13/211 (6%)

Query: 15  VILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDY-------PQAESVHRLDMAT 67
            ILY+DDH+++VNKP GLL  P     H    +  +   +        +   VHRLD  T
Sbjct: 87  EILYEDDHLLIVNKPVGLLLHPTERYHHVT--LDHLVSGHFFRTGLEAKVRHVHRLDQDT 144

Query: 68  SGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKV 127
           SGV++ A    A   L    RER  K+ YVA V G      G ++ P+  D  +  +++V
Sbjct: 145 SGVVLYAKHPWASALLDEMLRERTIKRTYVAYVSGQMPKERGKINEPIGKDRNHGTRRRV 204

Query: 128 CYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEAR 187
               G PA T Y+V E       +V  +  TGR+HQ+RVH   +GHP+LGD  Y     R
Sbjct: 205 -TPNGDPAITHYQVKERF-QTATKVECQLETGRTHQIRVHFSHIGHPLLGDELYGGK--R 260

Query: 188 AMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
            +  R  LHA +L   HP  G  +   AP  
Sbjct: 261 ELIKRQALHAAVLKFEHPFGGEVIEVTAPLP 291


>UniRef50_A6VZC6 Pseudouridine synthase n=2 Tax=Marinomonas RepID=A6VZC6_MARMS
          Length = 212

 Score =  259 bits (662), Expect = 6e-68,   Method: Composition-based stats.
 Identities = 97/207 (46%), Positives = 127/207 (61%), Gaps = 4/207 (1%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDMATSGVIVV 73
           L ILY+D+   V+NKP+  LSVPGR  +  DS++ R +  + +A ++HRLD ATSG+I+V
Sbjct: 9   LEILYEDEWFAVINKPANCLSVPGRGPDKLDSILYRAECLFGEAFAIHRLDEATSGLILV 68

Query: 74  ALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVC-YETG 132
           A T   ++ +   FRERE +K+Y A + GH    +G V  PL CDWPNRP+Q +C  E  
Sbjct: 69  AKTHECQKRMYAHFREREVQKEYRALLRGHLLGEKGEVRKPLRCDWPNRPRQIICTDEWS 128

Query: 133 KPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARAMAPR 192
           K + T +E + Y  +NT RV L P TGRSHQLRVHM +LGH I+GD FY         PR
Sbjct: 129 KDSITYWEKMAY-ENNTTRVRLVPFTGRSHQLRVHMQSLGHSIIGDEFYDPEFQND--PR 185

Query: 193 LLLHAEMLTITHPAYGNSMTFKAPADF 219
           LLLHA  L   HP     + F A   F
Sbjct: 186 LLLHAYRLEFRHPFTKAWIAFVAACPF 212


>UniRef50_B7GLK3 Pseudouridine synthase n=11 Tax=Bacillaceae RepID=B7GLK3_ANOFW
          Length = 292

 Score =  258 bits (661), Expect = 1e-67,   Method: Composition-based stats.
 Identities = 67/214 (31%), Positives = 108/214 (50%), Gaps = 9/214 (4%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ-----AESVHRLD 64
           +   L I+Y+DD+++V+NKP  + ++P R   H       +     Q        V RLD
Sbjct: 76  EPIPLAIVYEDDYVIVINKPPHMSTIPSREHPHGTLANALLHHYEQQQLQTTVHVVTRLD 135

Query: 65  MATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPK 124
             TSG+++VA  +     L  Q ++   K++Y A   G+     G +D P+     +  +
Sbjct: 136 RDTSGLVLVAKHRHVHHLLSEQQKQGRVKRRYEAVCHGYVIQLVGTIDAPIGRKGDSIIE 195

Query: 125 QKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASP 184
           ++V  + G+ A T YEV++   + T  V ++  TGR+HQ+RVH   +GHP++GD  Y   
Sbjct: 196 REVRLD-GQRAVTHYEVLQQKNEMT-HVSIQLETGRTHQIRVHFSHIGHPLVGDDLYGG- 252

Query: 185 EARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
             R    R  LH+  LT  HP +  +MTF AP  
Sbjct: 253 -LREHIDRQALHSCELTFFHPFFEKTMTFHAPLP 285


>UniRef50_C1AE05 Pseudouridine synthase n=1 Tax=Gemmatimonas aurantiaca T-27
           RepID=C1AE05_GEMAT
          Length = 476

 Score =  258 bits (660), Expect = 1e-67,   Method: Composition-based stats.
 Identities = 94/217 (43%), Positives = 121/217 (55%), Gaps = 10/217 (4%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAE---SVHRLDM 65
           P EP   ++Y+DDH++VVNKPSG+L+VPGR    +D VMTR++  YP A     VHRLD+
Sbjct: 264 PNEPA--VVYEDDHLLVVNKPSGMLTVPGRGPTMQDCVMTRLRARYPDATGQMVVHRLDL 321

Query: 66  ATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQ 125
            TSG+++ A        L+R F  RE  K YVA + G  +   G + LPL  D  +RP+ 
Sbjct: 322 DTSGLLLAAKDPITASALQRLFSLREIDKHYVAWLDGVVTDDHGHIHLPLRMDVDDRPRN 381

Query: 126 KVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLA---LGHPILGDRFYA 182
                 GKPA TE++V+    D   RV   P TGR+HQLRVH      L  PI+GDR Y 
Sbjct: 382 IHDPVFGKPAHTEWQVMAR-TDGRTRVRFTPHTGRTHQLRVHAAHPDGLDAPIVGDRLYG 440

Query: 183 SPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
              A     RL LHAE L   HP  G  +  + PA F
Sbjct: 441 -RTAPDEDERLQLHAERLAFVHPVSGAKVVVEQPAPF 476


>UniRef50_C1SM47 Pseudouridine synthase n=1 Tax=Denitrovibrio acetiphilus DSM 12809
           RepID=C1SM47_9BACT
          Length = 302

 Score =  258 bits (660), Expect = 1e-67,   Method: Composition-based stats.
 Identities = 61/218 (27%), Positives = 108/218 (49%), Gaps = 11/218 (5%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDY-------PQAESVH 61
           P +  + I+Y  D   V+NKP+G+   P       D+++  +  ++        +   VH
Sbjct: 76  PVKMDIEIIYDCDEFAVINKPAGITVHPAPGHAD-DTIVNAMLAEFDITDDNDLRPGIVH 134

Query: 62  RLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPN 121
           RLD  TSG+++VA  + +   L + F +R+  K+Y+A  WG P   E  ++ P+   + +
Sbjct: 135 RLDKDTSGLMIVAKNRKSREVLSKVFADRDIDKRYLAVCWGKPKELEFTIEQPIGRHYKD 194

Query: 122 RPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFY 181
           R +  V  E G+ +++   V++   +N     ++  TGR+HQ+RVHM   G P+ GD  Y
Sbjct: 195 RKRMCV-REDGRYSKSGVRVLKQN-NNAFLAEIRIFTGRTHQIRVHMSHAGFPLAGDVVY 252

Query: 182 ASPEARAM-APRLLLHAEMLTITHPAYGNSMTFKAPAD 218
              ++  +   R  LH+  L    P  G  M F++P  
Sbjct: 253 GHRQSLKLPIKRQALHSFRLAFVSPFTGEDMVFESPLP 290


>UniRef50_A5ZGG0 Pseudouridine synthase n=4 Tax=Bacteroides RepID=A5ZGG0_9BACE
          Length = 590

 Score =  258 bits (660), Expect = 1e-67,   Method: Composition-based stats.
 Identities = 95/247 (38%), Positives = 132/247 (53%), Gaps = 41/247 (16%)

Query: 7   NPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAE---SVHRL 63
           N  ++  L I+++D+ ++VVNKPSG+LSVPG+ EE  DSV  R++  YP A     VHRL
Sbjct: 351 NTHKDTELEIVFEDEWLVVVNKPSGMLSVPGK-EEDMDSVYHRLKEKYPDATGPMIVHRL 409

Query: 64  DMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAE--------------- 108
           DMATSG+++VA TK   + L+ QF  R  KK+Y+A + G  +  E               
Sbjct: 410 DMATSGLLLVAKTKEVHQHLQAQFENRSIKKRYIALLDGCITETEETTNQTTGNTRKTEK 469

Query: 109 -------------GLVDLPLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLK 155
                        G ++LPL  +  +RP Q V  E GK A TEY+++   ++   R+   
Sbjct: 470 VRATEVISTTGKVGRIELPLCPNPLDRPCQSVDEEHGKEAITEYQII-TNSEKHTRIAFC 528

Query: 156 PITGRSHQLRVHMLA---LGHPILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMT 212
           P+TGR+HQLRVH      L  PILGD  Y        A RL LHAE +   HP YG+ + 
Sbjct: 529 PLTGRTHQLRVHAAHPKGLNCPILGDELYGKK-----ADRLYLHAEYIEFRHPIYGDIIC 583

Query: 213 FKAPADF 219
            +   DF
Sbjct: 584 IQKEPDF 590


>UniRef50_Q03WF6 Pseudouridine synthase n=9 Tax=Firmicutes RepID=Q03WF6_LEUMM
          Length = 312

 Score =  258 bits (660), Expect = 1e-67,   Method: Composition-based stats.
 Identities = 61/203 (30%), Positives = 97/203 (47%), Gaps = 11/203 (5%)

Query: 25  VVNKPSGLLSVPGRLEEHKDSVMTRIQR-------DYPQAESVHRLDMATSGVIVVALTK 77
           VVNKP G++  P         V   +            +   VHR+D  TSG+++VA   
Sbjct: 90  VVNKPQGMVVHPAAGHSSGTLVNALLHHSPLSTINGEFRPGIVHRIDRDTSGLLMVAKND 149

Query: 78  AAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYETGKPAQT 137
            A R L  Q +  + ++ Y A V G  +   G ++ P+     +R KQ V  E G+ A T
Sbjct: 150 KAHRSLSEQLKSHKNQRVYYALVRGEFTEDSGTIEAPIGRHKIDRKKQAVI-EGGREAVT 208

Query: 138 EYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPE--ARAMAPRLLL 195
            + V++        + +   TGR+HQ+RVHM  +GHP++GD  Y + +          LL
Sbjct: 209 HFRVLKRYV-GYTLLKVSLETGRTHQIRVHMSYIGHPVVGDPVYGTAQKLDGTQLNGQLL 267

Query: 196 HAEMLTITHPAYGNSMTFKAPAD 218
           HA+ LT+  P  G+ ++F +P  
Sbjct: 268 HAKTLTLEQPTTGDELSFDSPLP 290


>UniRef50_A1AW00 Pseudouridine synthase n=2 Tax=sulfur-oxidizing symbionts
           RepID=A1AW00_RUTMC
          Length = 314

 Score =  258 bits (660), Expect = 1e-67,   Method: Composition-based stats.
 Identities = 76/226 (33%), Positives = 116/226 (51%), Gaps = 20/226 (8%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRD-----YPQAESVHRLD 64
           Q+  + ++Y+D+ I++VNKP  L++ PG            +  D       +A  VHRLD
Sbjct: 76  QDIVIDVVYEDEAIIIVNKPVNLVTHPGVSNWTGTLANALLHYDSSLANLDRAGIVHRLD 135

Query: 65  MATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPK 124
             TSG++VVA ++ A++ L RQ +     ++Y A V+GH     G VD P+  D  +R +
Sbjct: 136 KNTSGLMVVARSEYAQKYLTRQLQTHSISREYSAIVYGHMISG-GTVDKPIGRDPKDRIR 194

Query: 125 QKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYAS- 183
           Q V  E+GK A T Y V+E  A +T  V +   TGR+HQ+RVH+  +GHP++ D  Y   
Sbjct: 195 QTV-TESGKDALTHYRVIERFAHHT-HVKVMLETGRTHQIRVHLSFIGHPLIADPMYGGK 252

Query: 184 -----------PEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
                        +     R  LHA+ LT+ HP     M++K P  
Sbjct: 253 IRFPKKADKQLKNSLKNFNRQTLHAKKLTLIHPTSTELMSWKVPLP 298


>UniRef50_B6BTN1 Pseudouridine synthase n=2 Tax=Betaproteobacteria
           RepID=B6BTN1_9PROT
          Length = 346

 Score =  257 bits (659), Expect = 1e-67,   Method: Composition-based stats.
 Identities = 69/230 (30%), Positives = 105/230 (45%), Gaps = 22/230 (9%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRI-----QRDYPQAESVHRLD 64
           +   L I+Y+DD I+V+NKP  L+  PG    +   +   +         P+   VHRLD
Sbjct: 80  ENISLDIVYEDDDILVLNKPYNLVVHPGSGNANGTLLNGLLYYNKDLEKLPRGGIVHRLD 139

Query: 65  MATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPK 124
             T+G++VVA  + ++  L  Q + +   ++Y A VWG     + ++  P+      R K
Sbjct: 140 KDTTGLMVVAKNEESQNNLISQLQSKSVYREYRAIVWGQIWQNK-VIQKPIGRHPRQRTK 198

Query: 125 QKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASP 184
             V    GK A+T+ E++E    +T  V     TGR+HQ+RVHML    PI+GD+ Y   
Sbjct: 199 MAVTKVNGKDAETKLEILERFNYHT-YVRCLLKTGRTHQIRVHMLDNNSPIVGDKDYGLK 257

Query: 185 -------------EARAMAPRLLLHAEMLTITHPAYGNSM--TFKAPADF 219
                        ++     R  LHA  L + HP     M  T   P D 
Sbjct: 258 KIIPTKNMEMDLLKSIKNFDRQALHAIALGLIHPKTNKEMKWTIDLPEDM 307


>UniRef50_A1HR26 Pseudouridine synthase, RluA family n=1 Tax=Thermosinus
           carboxydivorans Nor1 RepID=A1HR26_9FIRM
          Length = 301

 Score =  257 bits (658), Expect = 2e-67,   Method: Composition-based stats.
 Identities = 71/222 (31%), Positives = 110/222 (49%), Gaps = 10/222 (4%)

Query: 2   GMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQA---- 57
           G ++   P +  L I+Y+DD +++VNKP+GLL  P             +   + +     
Sbjct: 63  GDDSCLTPMKMPLHIVYEDDFLLIVNKPAGLLVHPTSDPTEPTLAHGILYYLHSKGALGA 122

Query: 58  -ESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLI 116
              +HRLD  TSG++ +A     +  L      +  K+ Y+A V G PS   G +D P+ 
Sbjct: 123 FHPIHRLDRNTSGLVAIAKHPHIQHALSG-GGAKGLKRLYLAVVTGIPSSLMGRIDAPIG 181

Query: 117 CDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPIL 176
              PN   ++V    G+PA T Y V+   +   + V L+ +TGR+HQ+RVH+  +GHP+L
Sbjct: 182 RH-PNSIIKRVVRSDGQPAITLYRVLSTFSM-ASLVELELLTGRTHQIRVHLSHIGHPLL 239

Query: 177 GDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           GD  Y    A  +  R  LHA  L+  HPA    +T  +P  
Sbjct: 240 GDDLYGG--ATDLIRRQALHAASLSFRHPATDKVLTLTSPLP 279


>UniRef50_A0Q1S9 Pseudouridine synthase n=32 Tax=Clostridium RepID=A0Q1S9_CLONN
          Length = 301

 Score =  257 bits (658), Expect = 2e-67,   Method: Composition-based stats.
 Identities = 66/219 (30%), Positives = 112/219 (51%), Gaps = 12/219 (5%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ------AESVHR 62
           P++  L ++Y+D  I+V+NKP G++  P +  ++  ++   +   + +         V+R
Sbjct: 78  PEKMHLDVIYEDKDIVVINKPKGIVVHPTKRHQNG-TLSNGVLYYFKEKNENSIVRLVNR 136

Query: 63  LDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNR 122
           LDM TSG++++A    +   L R  ++ +  K Y+A V G+     G+++ P+       
Sbjct: 137 LDMDTSGLVLIAKNAYSHMALSRDMQKDDFVKSYLAIVHGNLKEKSGVINKPIYRVGEG- 195

Query: 123 PKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYA 182
             ++V  E G+ + T ++VVE   D    V L   TGR+HQ+RVH+ ++GHPI GD  Y 
Sbjct: 196 TLRRVIDERGQRSVTRFKVVESYED-ADLVELTLETGRTHQIRVHLSSIGHPIYGDSLYG 254

Query: 183 SPEARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
             E      R  LHA  L I HP  G  +  ++  P D 
Sbjct: 255 -KEEHEYIDRQALHAYKLQIPHPKDGRILKLESDLPDDM 292


>UniRef50_A0LPH5 Pseudouridine synthase n=1 Tax=Syntrophobacter fumaroxidans MPOB
           RepID=A0LPH5_SYNFM
          Length = 344

 Score =  257 bits (658), Expect = 2e-67,   Method: Composition-based stats.
 Identities = 75/239 (31%), Positives = 119/239 (49%), Gaps = 24/239 (10%)

Query: 4   ENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQ-------RDYPQ 56
           E+   P+   L IL++DD ++V+NK  G++  PG   E    V   +        R  P+
Sbjct: 77  EDSLQPRPMPLEILFEDDDVLVLNKAPGVIVHPGAGHEEGTLVHGLLAHCSRLASRGAPR 136

Query: 57  -AESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPL 115
               VHRLD  TSG ++VA ++ A  EL RQF+  E  K+Y+A V+G  + A G +   +
Sbjct: 137 RPGIVHRLDRGTSGALMVAKSERAYLELIRQFKHHEVGKEYLALVYGTMAGASGEIRTGM 196

Query: 116 ICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPI 175
                +R +  V  + G+ A ++++V   A    + + +   TGR+HQ+RVH+  + HP+
Sbjct: 197 GRHPVDRKRMAVLEKGGREAVSQWKV-AVAWGEVSLLRVVIKTGRTHQIRVHLSHMQHPV 255

Query: 176 LGDRFYASPEARAMA-------------PRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
           +GD  Y   + +A A              R +LHA  L   HP  G  ++F A  P DF
Sbjct: 256 VGDETYGGGKRKARAVKSDVLRELLMEVDRQMLHAVGLAFRHPVSGADLSFTAPLPPDF 314


>UniRef50_C4XFS9 Pseudouridine synthase n=2 Tax=Mycoplasma RepID=C4XFS9_MYCFE
          Length = 315

 Score =  257 bits (657), Expect = 2e-67,   Method: Composition-based stats.
 Identities = 57/224 (25%), Positives = 99/224 (44%), Gaps = 18/224 (8%)

Query: 8   PPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP----------QA 57
            P    L I Y+DD ++++NKPS L+  P     + D+++  +   +           + 
Sbjct: 78  EPVNIPLDIKYEDDDLVIINKPSNLVVHPSPGH-YNDTLVNGLLYHFKNNLSNENGLLRP 136

Query: 58  ESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLIC 117
             VHR+D  TSG++++A        L    +  E ++ Y+A V G        ++LP+  
Sbjct: 137 GIVHRIDKDTSGLLIIAKNNKMHNSLTDMLKRHEIERSYLAIVRGLIENPLTKINLPIAR 196

Query: 118 DWPNRPKQKVCYETGKPAQTEYEVVEYA---ADNTARVVLKPITGRSHQLRVHMLALGHP 174
           +  +R K    ++ GK A T   ++++     +  + V  +  TGR+HQ+RVH+  + HP
Sbjct: 197 NTVDR-KMMSVHKEGKEAITFVHLLKHFYLDKEPMSLVRCELKTGRTHQIRVHLSYIKHP 255

Query: 175 ILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           + GD  Y             LHA  L   HP     +   AP  
Sbjct: 256 VYGDPTYGKSVDEFN---QRLHAYKLKFIHPLTKKEICVYAPVP 296


>UniRef50_C0GNZ6 Pseudouridine synthase, RluA family n=1 Tax=Desulfonatronospira
           thiodismutans ASO3-1 RepID=C0GNZ6_9DELT
          Length = 535

 Score =  257 bits (657), Expect = 2e-67,   Method: Composition-based stats.
 Identities = 77/239 (32%), Positives = 114/239 (47%), Gaps = 22/239 (9%)

Query: 2   GMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVM--------TRIQRD 53
                  P    L I+Y D  ++V+NKP+GL   P   +     V          R+  D
Sbjct: 71  EENEDLEPVAGKLDIVYMDREMVVLNKPAGLSVHPSSSDPAPTLVHYLLYACPGLRLMTD 130

Query: 54  YPQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDL 113
             +   VHRLD  T+G++V AL + A+ +L  QF  R   K Y+A V G     EG++++
Sbjct: 131 RQRPGIVHRLDKDTTGLMVAALNQEAKEDLAGQFAGRRVHKTYLALVCGALKQDEGIINV 190

Query: 114 PLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNT-ARVVLKPITGRSHQLRVHMLALG 172
           PL  D  +R +     E G+ A+T Y+V++       + V ++  TGR+HQ+RVH   L 
Sbjct: 191 PLARDQQSRARVAPSRE-GRSARTAYKVLKRDPSGLWSLVQVQIFTGRTHQIRVHFSHLN 249

Query: 173 HPILGDRFYASPEAR----------AMAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
           HP+LGDR Y   +             +A R LLH+  L I HP     + F +  P DF
Sbjct: 250 HPVLGDRIYGGTDWDRFGWKKRFLSRLAKRQLLHSSCLGIMHPVSRQWLEFISRPPRDF 308


>UniRef50_Q2NIN6 Pseudouridine synthase n=4 Tax=Candidatus Phytoplasma
           RepID=Q2NIN6_AYWBP
          Length = 306

 Score =  257 bits (657), Expect = 2e-67,   Method: Composition-based stats.
 Identities = 66/222 (29%), Positives = 111/222 (50%), Gaps = 13/222 (5%)

Query: 5   NYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDY--------PQ 56
           N   PQ   L I+Y+D ++ V+NKP+ L+  P  L   K +++  +   +         +
Sbjct: 73  NLQTPQNLNLDIIYEDPYLAVINKPANLVVHPS-LSFQKTTLVNGLLHQFNTLSHIDTQR 131

Query: 57  AESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLI 116
              VHRLD  T+G+++VA T     +L+  F++R+  K Y A + G     +G++ LP+ 
Sbjct: 132 PGIVHRLDKNTTGLLIVAKTNDVSDKLQIAFQQRKITKIYWALIEG-FLEDKGIIKLPIG 190

Query: 117 CDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPIL 176
            +  NR K +V    GK A T ++ ++  + + + +     TGR+HQLR H   L HPI+
Sbjct: 191 RNNHNRLKMQV-MPDGKTAVTHFKTLQRFS-HFSLMECNLETGRTHQLRAHFSFLKHPIV 248

Query: 177 GDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           GD  Y S           LH+++L   HP    ++  +AP  
Sbjct: 249 GDLLYDSSHHITPL-GQFLHSKILKFNHPITNQNLILEAPLP 289


>UniRef50_C5VJ38 Pseudouridine synthase n=2 Tax=Prevotella RepID=C5VJ38_9BACT
          Length = 571

 Score =  257 bits (657), Expect = 2e-67,   Method: Composition-based stats.
 Identities = 92/217 (42%), Positives = 120/217 (55%), Gaps = 18/217 (8%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRL-EEHKDSVMTRIQRDYPQAESVHRLDMATSGVIV 72
           L ILY+DD++ VV KPSGLLS+PG+  +    S++    +    A  VHRLDMATSG++V
Sbjct: 360 LQILYEDDYLAVVVKPSGLLSIPGKGCQASIYSILCERWKGKSDAFMVHRLDMATSGLLV 419

Query: 73  VALTKAAERELKRQFREREPKKQYVAR----VWGHPSPAEGLVDLPLICDWPNRPKQKVC 128
           VA T    + L+ QF  R  KK+YVA     +     PAEG ++LPL  D  +RP+Q+V 
Sbjct: 420 VARTSEVHKALQAQFIGRTVKKKYVALLPLSILEKQLPAEGRIELPLSPDPDDRPRQRVD 479

Query: 129 YETGKPAQTEYEVVEYAADN-----TARVVLKPITGRSHQLRVHMLA---LGHPILGDRF 180
              GKPA TEY ++             ++ L P+TGR+HQLRVH      LG PI+GD  
Sbjct: 480 RTNGKPAITEYRLIGKTTYGKEALEAVKIALYPLTGRTHQLRVHCAHPDGLGTPIIGDNL 539

Query: 181 YASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPA 217
           Y        A RL LHA  L  THP     M+F  P 
Sbjct: 540 YGQR-----AERLWLHATHLEFTHPITQERMSFDTPL 571


>UniRef50_A8MF48 Pseudouridine synthase n=12 Tax=Clostridiaceae RepID=A8MF48_ALKOO
          Length = 305

 Score =  257 bits (657), Expect = 3e-67,   Method: Composition-based stats.
 Identities = 74/223 (33%), Positives = 119/223 (53%), Gaps = 14/223 (6%)

Query: 5   NYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES----- 59
           N+   Q+     +Y+D  +++VNK  G+++ P +   H D  +      Y +++      
Sbjct: 77  NHFTLQDVPFEAVYEDVDLILVNKEPGIVTHPTK--SHPDWTIANGAALYLKSKGIDCKV 134

Query: 60  --VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLIC 117
             V+RLDM TSG++++A    A   L  Q +E   +K+Y+A VWG     EG ++ P+  
Sbjct: 135 RFVNRLDMDTSGLLIIAKNAYAHHVLSEQMQEDRIEKKYIAFVWGVIKEDEGRIEAPIYR 194

Query: 118 DWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILG 177
              +  K+ V  E G+ + TE++V+E    N   V +K +TGR+HQ+RVHM  LGHP++G
Sbjct: 195 TTMDSIKR-VVDERGQESITEFKVLERYK-NATMVEVKLLTGRTHQIRVHMEHLGHPLIG 252

Query: 178 DRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PAD 218
           D  Y   +A  +  R  LHAE L    P +  ++  KA  PAD
Sbjct: 253 DTLYGKEDAE-LIDRQALHAEYLRFWQPRFKRAIEVKADLPAD 294


>UniRef50_B8CWB7 Pseudouridine synthase n=1 Tax=Halothermothrix orenii H 168
           RepID=B8CWB7_HALOH
          Length = 310

 Score =  257 bits (657), Expect = 3e-67,   Method: Composition-based stats.
 Identities = 69/221 (31%), Positives = 114/221 (51%), Gaps = 8/221 (3%)

Query: 3   MENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMT-----RIQRDYPQA 57
            + Y  P    L I+Y+D H++V+NKP+ +L  P  +E+    V       R Q +Y   
Sbjct: 82  EKTYYDPAPLDLDIIYEDRHLLVINKPANMLVHPTPVEKSNTIVNGVLYHMRNQGNYNLV 141

Query: 58  ESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLIC 117
             +HRLD  T+G++++A  + A   +  QF+     ++Y+A V G+    +  ++ P+  
Sbjct: 142 RPIHRLDRNTTGLLLIAKNQYAHNYITHQFQNNNIHREYLAFVHGNVEFKKESINAPIGK 201

Query: 118 DWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILG 177
              +  K+KV +  GK A T  +VV+      + + +K  TGR+HQ+RVH+  LGHP+LG
Sbjct: 202 TRDSLIKRKVDHTLGKRAVTHIKVVK-PGGLISLIRVKLETGRTHQIRVHLSHLGHPLLG 260

Query: 178 DRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           D  Y   +   +  R  LH+  +T   P     +TFKAP  
Sbjct: 261 DTLYGGEDI--LIKRPALHSYKVTCCLPFKHKEVTFKAPLP 299


>UniRef50_B1Y046 Pseudouridine synthase n=43 Tax=Proteobacteria RepID=B1Y046_LEPCP
          Length = 256

 Score =  256 bits (656), Expect = 3e-67,   Method: Composition-based stats.
 Identities = 111/218 (50%), Positives = 137/218 (62%), Gaps = 7/218 (3%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDMATS 68
           P EP + IL+ DD ++VV KP+GLLSVPGR E  +D V  R+Q  +P A  VHRLDMATS
Sbjct: 39  PSEPLIDILHHDDSLLVVRKPAGLLSVPGRGEHLQDCVAARVQAIWPDALIVHRLDMATS 98

Query: 69  GVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVC 128
           G++V+A   AA+R L   F  R   KQYVA V G  +   G VDLPL  DWPNRP+QKV 
Sbjct: 99  GLMVMARGPAAQRALGSAFEHRSVTKQYVAVVAGDVAGDAGSVDLPLCADWPNRPRQKVD 158

Query: 129 YETGKPAQTEYEVVEYAADNT-------ARVVLKPITGRSHQLRVHMLALGHPILGDRFY 181
              G+P+ T +     A + +        R+ L+P+TGRSHQLRVH+LALGHPILGD  Y
Sbjct: 159 AAMGRPSLTHWRRATPAHEGSTTGDIDRTRLELEPVTGRSHQLRVHLLALGHPILGDTLY 218

Query: 182 ASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
           A    + MAPRLLLHA  + + HPA G    F  P  F
Sbjct: 219 APDAVQRMAPRLLLHASRIALPHPAGGGICVFSDPPAF 256


>UniRef50_A9BWX6 Pseudouridine synthase n=2 Tax=Comamonadaceae RepID=A9BWX6_DELAS
          Length = 245

 Score =  256 bits (656), Expect = 4e-67,   Method: Composition-based stats.
 Identities = 93/211 (44%), Positives = 131/211 (62%), Gaps = 8/211 (3%)

Query: 17  LYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDMATSGVIVVALT 76
           LY+D  ++V++KPSGLL VPGR  + +D +  R  + +P A  VHRLD ATSG++V+A +
Sbjct: 35  LYEDAELLVLDKPSGLLCVPGRGPDKQDCLSGRALQRWPDALVVHRLDQATSGLVVMARS 94

Query: 77  KAAERELKRQFREREPKKQYVARVWGHPSPAE----GLVDLPLICDWPNRPKQKVCYETG 132
            A++R L   F +R   K YVA V G P+  +      +DLP+  DW  RP + +    G
Sbjct: 95  LASQRLLSEAFAQRRVHKLYVAVVAGRPAAQQADAWQSIDLPIAADWERRPLRIIDALQG 154

Query: 133 KPAQTEYEVVEYAADN----TARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARA 188
           KP+QT +  +  A +     T RV L+P+TGR+HQLRVHM ALGH ILGD  YA    +A
Sbjct: 155 KPSQTLWRAMPAATEGHDTPTTRVQLQPVTGRTHQLRVHMAALGHAILGDALYADAAVQA 214

Query: 189 MAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
           ++PRLLLHA  L + HP  G ++ F++   F
Sbjct: 215 LSPRLLLHAHQLELAHPLSGQTLRFESAVPF 245


>UniRef50_C7PHX6 Pseudouridine synthase n=1 Tax=Chitinophaga pinensis DSM 2588
           RepID=C7PHX6_CHIPD
          Length = 570

 Score =  256 bits (656), Expect = 4e-67,   Method: Composition-based stats.
 Identities = 92/212 (43%), Positives = 126/212 (59%), Gaps = 13/212 (6%)

Query: 13  WLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAE--SVHRLDMATSGV 70
            L I+YQD+ ++VVNKPSGL SVPG     +DSV TR++      E   VHRLDM TSG+
Sbjct: 367 ELDIIYQDESVVVVNKPSGLRSVPG--VTIQDSVYTRLKHALGDIEPLIVHRLDMDTSGL 424

Query: 71  IVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYE 130
           +VVA T+AA + ++RQF +R   K+Y A +      +EG +DLPL  D  NRP+Q VC+ 
Sbjct: 425 LVVAKTQAAHKHIQRQFLQRTVSKRYTALLSKVIDTSEGEIDLPLTADLFNRPRQIVCFT 484

Query: 131 TGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLA---LGHPILGDRFYASPEAR 187
           TGK + T ++VV      T ++   P+TGR+HQLR+H      L  PI+GD  Y +    
Sbjct: 485 TGKKSVTRWKVVTRYQAMT-KIDFWPLTGRTHQLRMHSAHPLGLNAPIVGDDLYGTA--- 540

Query: 188 AMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
             A R+ LHA  +  THP     ++F AP  F
Sbjct: 541 --AERMYLHAAHIEFTHPLSRQRISFDAPVTF 570


>UniRef50_B3DV48 Pseudouridine synthase n=1 Tax=Methylacidiphilum infernorum V4
           RepID=B3DV48_METI4
          Length = 325

 Score =  256 bits (656), Expect = 4e-67,   Method: Composition-based stats.
 Identities = 68/217 (31%), Positives = 106/217 (48%), Gaps = 10/217 (4%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRD--------YPQAESVH 61
           +E  L ILY+D+ I++VNK  G++  P         V + +             +   VH
Sbjct: 87  EEIALEILYEDEEILIVNKQRGMVVHPSCGHWSGTLVNSLLFHYGESLPGSSLLRPGIVH 146

Query: 62  RLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPN 121
           RLD  TSGV+V+A T+ + + L  QF +R  +K Y+              +  +     +
Sbjct: 147 RLDKDTSGVMVIAKTERSLKSLLLQFSQRTVQKVYLCLCKNRFPYLRYSFEANIHRHASD 206

Query: 122 RPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFY 181
           R K  V    GK A+T + ++ +A+   + +  +P++GR+HQ+RVH+  LG PI+GD  Y
Sbjct: 207 RKKMAVHRLKGKTAETRFTLL-FASSQASFLKCEPVSGRTHQIRVHLSHLGFPIIGDPLY 265

Query: 182 ASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
                +   P LLLHA  L I HP  G  + F AP  
Sbjct: 266 GKGVRKYPFP-LLLHAYALKIEHPRSGKKIEFMAPLP 301


>UniRef50_A4RT55 Predicted protein (Fragment) n=3 Tax=Chlorophyta RepID=A4RT55_OSTLU
          Length = 332

 Score =  256 bits (655), Expect = 4e-67,   Method: Composition-based stats.
 Identities = 81/270 (30%), Positives = 120/270 (44%), Gaps = 57/270 (21%)

Query: 7   NPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR-------------- 52
            P     L I+++D+ ++VVNK +G+++ P    E    V   +                
Sbjct: 63  KPEPWVKLDIVHEDESVLVVNKAAGMVTHPSAGHESGTLVNAVLGHCDLPELVVPTGNQA 122

Query: 53  --------------------DYPQAESVHRLDMATSGVIVVALTKAAERELKRQFREREP 92
                                  +   VHRLD  TSGV+VVA   +A   L  QF  R  
Sbjct: 123 LSDDDEDDEDAVDEDEGARDGMIRPGIVHRLDKGTSGVMVVAKDASAHNSLCEQFAARVV 182

Query: 93  KKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYETGKPAQTEYEVVEYAAD-NTAR 151
           +++YVA + G PSP++G ++ P+  D  +R +  V    G+ A + YEV+   A+ N + 
Sbjct: 183 RRKYVAILSGVPSPSKGRIEAPIGRDPRDRLRMAVTQGGGRFAASNYEVIATLANGNASL 242

Query: 152 VVLKPITGRSHQLRVHMLALGHPILGDRFYAS-----------------PEARAM---AP 191
           V  +  TGR+HQ+RVH   +GHPILGD  Y                    EA+A+     
Sbjct: 243 VEWRLETGRTHQIRVHAKHIGHPILGDDTYGGGGGAAVSALSRYGVFDVKEAKALMSTID 302

Query: 192 RLLLHAEMLTITHPAYGNSMTFK--APADF 219
           R +LHA  L  THP  G ++ F    P DF
Sbjct: 303 RPMLHARTLGFTHPQSGEALDFSRDPPEDF 332


>UniRef50_C2W5F3 Pseudouridine synthase n=4 Tax=Bacillus RepID=C2W5F3_BACCE
          Length = 307

 Score =  256 bits (655), Expect = 4e-67,   Method: Composition-based stats.
 Identities = 64/223 (28%), Positives = 105/223 (47%), Gaps = 9/223 (4%)

Query: 2   GMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKD-----SVMTRIQRDYPQ 56
             E    P+   L ++++DDH+++VNKP+ + + P             +   ++Q    +
Sbjct: 73  QEEYGVQPEYGDLEVIFEDDHVLIVNKPAHMDTHPSNKGGTGTLANLVAFHLQMQGVETK 132

Query: 57  AESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLI 116
              +HRLD  T+G +V A    A   + R   ER  K+ Y+A V G     +G++D  + 
Sbjct: 133 VRHIHRLDKDTTGGVVFAKHGIAGVIMDRLLMERNIKRTYLALVEGKVRKKQGIIDEAIG 192

Query: 117 CDWPNRPKQKVCYETGKPAQTEYEVVEYAADN-TARVVLKPITGRSHQLRVHMLALGHPI 175
            D  +  +++V  + G  A T Y++ +Y        V L+  TGR+HQ+RVHM   GHP+
Sbjct: 193 RDRHHATRRRV-SQKGDRAVTHYKIEKYFKKQDVTLVTLQLETGRTHQIRVHMSHSGHPL 251

Query: 176 LGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           +GD  Y         P   LHA  +   HP     +T +AP  
Sbjct: 252 IGDVLYGGQAT--YMPYQALHAMRIHFLHPITKEEITVEAPLP 292


>UniRef50_Q6FCX9 Pseudouridine synthase n=1 Tax=Acinetobacter sp. ADP1
           RepID=Q6FCX9_ACIAD
          Length = 214

 Score =  256 bits (655), Expect = 4e-67,   Method: Composition-based stats.
 Identities = 89/206 (43%), Positives = 124/206 (60%), Gaps = 4/206 (1%)

Query: 17  LYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDMATSGVIVVALT 76
           +++D+  MV++KP+G+LSVPG+ +   DS++ R+    P+   +HRLD  TSG++V  L 
Sbjct: 10  IHRDNDFMVIHKPAGILSVPGKGDALFDSLLVRLVEIEPKTLLIHRLDRDTSGILVFGLN 69

Query: 77  KAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYETGKPAQ 136
           K A+  + RQF+ER+  K Y A V G     EGL+D+P++ D    P         KPAQ
Sbjct: 70  KMAQSAISRQFQERQTDKIYQALVVGEVY-GEGLIDVPVVYDAARPPLHIADPAHHKPAQ 128

Query: 137 TEYEVVEYAADN---TARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARAMAPRL 193
           TE++ +E    N     R+ L PITGRSHQLRVHM  +GHPI+GD  YAS   + +  RL
Sbjct: 129 TEWQALEQFELNGKMVTRMRLTPITGRSHQLRVHMQYIGHPIVGDTLYASLADQQLVSRL 188

Query: 194 LLHAEMLTITHPAYGNSMTFKAPADF 219
            LHAE L+  HP  G  +TF  P  F
Sbjct: 189 CLHAEQLSFYHPKTGELVTFHCPVPF 214


>UniRef50_C8X1I9 Pseudouridine synthase, RluA family n=1 Tax=Desulfohalobium
           retbaense DSM 5692 RepID=C8X1I9_DESRD
          Length = 547

 Score =  256 bits (655), Expect = 4e-67,   Method: Composition-based stats.
 Identities = 75/231 (32%), Positives = 117/231 (50%), Gaps = 21/231 (9%)

Query: 3   MENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP------- 55
           +++   P+   + ++Y D  ++VVNK +G+   PG   E   +++  +   YP       
Sbjct: 80  LQSGIKPEVGPVEVVYSDPDVVVVNKAAGVTVHPGTGCESG-TLVHHLAALYPELARFDG 138

Query: 56  -QAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLP 114
            +   VHRLD  TSG++ VAL ++A   L R F  RE  K+Y+  V G P  AEG VD P
Sbjct: 139 ERPGVVHRLDKDTSGLLTVALNESARLALTRSFARREVDKEYLTLVHGRP-EAEGTVDHP 197

Query: 115 LICDWPNRPKQKVCYETGKPAQTEYEVVEYAAD-NTARVVLKPITGRSHQLRVHMLALGH 173
           L  D  ++ +  V    GK A T ++ V  + D   + + ++ +TGR+HQ+RVHM  LG 
Sbjct: 198 LGRDPQSKIRMAVVPRGGKEALTRFKRVWTSPDGRVSLLRVRILTGRTHQIRVHMAYLGF 257

Query: 174 PILGDRFYAS------PEARAMAPRL----LLHAEMLTITHPAYGNSMTFK 214
           P++GD  Y          +R +  RL    +LHA  L   HP  G  +  +
Sbjct: 258 PLVGDALYGPQAQAAFQRSRPLLARLAKHHMLHAWRLAFPHPRSGRMVCCE 308


>UniRef50_Q63E77 Pseudouridine synthase n=73 Tax=Bacillaceae RepID=Q63E77_BACCZ
          Length = 307

 Score =  255 bits (654), Expect = 5e-67,   Method: Composition-based stats.
 Identities = 68/224 (30%), Positives = 103/224 (45%), Gaps = 9/224 (4%)

Query: 1   MGMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVP---GRLEEHKDSVMTRIQRDYP-- 55
           M  E    P+   L ++Y+DDH+++VNKP  + + P   G +    + V    Q      
Sbjct: 72  MEEEYDVEPEYGELHVVYEDDHVLIVNKPEKMDTHPSEKGGMGTLANLVAFHFQMQGLET 131

Query: 56  QAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPL 115
           +   +HRLD  T+G +V A  + A   + R   ER+ K+ Y A V G     +G +D  +
Sbjct: 132 KVRHIHRLDKDTTGGVVFAKHRIAGAIMDRLLMERKIKRTYAALVEGKVKKKQGTIDAAI 191

Query: 116 ICDWPNRPKQKVCYETGKPAQTEYEVVEYA-ADNTARVVLKPITGRSHQLRVHMLALGHP 174
             D  +  +++V    G  A T Y+V EY    N   V L+  TGR+HQ+RVHM   G+P
Sbjct: 192 GRDRHHATRRRV-SPKGDQAITYYKVEEYFKKQNVTLVTLQLETGRTHQIRVHMSYNGNP 250

Query: 175 ILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           ++GD  Y          R  LHA  +   HP     +    P  
Sbjct: 251 LVGDVLYGGGT--KYMSRQALHAMKINFLHPITKEEIEVDVPFP 292


>UniRef50_C5J6Q2 Pseudouridine synthase n=1 Tax=Mycoplasma conjunctivae HRC/581
           RepID=C5J6Q2_MYCCR
          Length = 306

 Score =  255 bits (653), Expect = 7e-67,   Method: Composition-based stats.
 Identities = 74/238 (31%), Positives = 116/238 (48%), Gaps = 26/238 (10%)

Query: 3   MENYNPPQ------EPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP- 55
           + NY  PQ      +    I+YQD+ I+V+NKP  L+  PG     K +++  +  ++  
Sbjct: 65  LNNYQEPQLKVEAQKVDFEIVYQDNDIIVINKPKNLVVHPGNGNWDK-TLVNGLLHEFAT 123

Query: 56  ---------QAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSP 106
                    +   VHRLD  TSG+++VA    A + L +Q    E +++Y+A V G    
Sbjct: 124 NLSDVNGEIRPGIVHRLDKDTSGLLLVAKNNQAHKYLAKQLENHEIERKYIAIVVGKIPH 183

Query: 107 AEGLVDLPLICDWPNRPKQKVCYETGKPAQTEYEVVE---YAADNTARVVLKPITGRSHQ 163
            +  ++LP+  D  NR K+ V     K A T  E++    Y  ++ + V     TGR+HQ
Sbjct: 184 TKMRINLPIGRDNQNRTKKVVSSFNSKNAITNVELINTFVYKNEHFSIVKCILETGRTHQ 243

Query: 164 LRVHMLALGHPILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
           +RVH+  +G+PI GD  Y   +   +  R  LHA  +T  H   G  M FK   P +F
Sbjct: 244 IRVHLSHIGYPIYGDPVYG-KKIDDLGQR--LHAYEITFKH-LDGRLMNFKTEMPDEF 297


>UniRef50_C9M7B4 Pseudouridine synthase n=1 Tax=Jonquetella anthropi E3_33 E1
           RepID=C9M7B4_9BACT
          Length = 301

 Score =  255 bits (653), Expect = 7e-67,   Method: Composition-based stats.
 Identities = 71/223 (31%), Positives = 112/223 (50%), Gaps = 10/223 (4%)

Query: 4   ENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP------QA 57
           E    PQ+     +Y DD + VV K +G+   PG   +    V   ++   P      + 
Sbjct: 68  EESVVPQDVPFRTVYADDWLAVVEKLAGIAVHPGAGRKDGTLVNGLVKTFGPLPGAGLRP 127

Query: 58  ESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLIC 117
             VHRLD+ TSG++VVA T  A   L+R+F +R  +K Y+A V G    ++G +D P+  
Sbjct: 128 GIVHRLDIGTSGLMVVARTPQAYLFLQREFSQRRVEKTYLALVHGWIPASQGTLDGPIGR 187

Query: 118 DWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILG 177
              +R K  V    G+ A T Y  + +   + +    +  TGR+HQ+RVHM ++G  + G
Sbjct: 188 SRYDRLKMAV-RADGRRAVTRYRTL-WTRGSLSLTACRIETGRTHQIRVHMASIGCYLDG 245

Query: 178 DRFYASPEA--RAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           DR Y   +     +  R+ LHA  L+  HP+ G +M F++P  
Sbjct: 246 DRLYGPKDVSRHFLEGRVFLHAWRLSFHHPSDGRTMNFRSPLP 288


>UniRef50_B0VCN8 Pseudouridine synthase n=16 Tax=Acinetobacter RepID=B0VCN8_ACIBY
          Length = 212

 Score =  255 bits (653), Expect = 7e-67,   Method: Composition-based stats.
 Identities = 95/206 (46%), Positives = 128/206 (62%), Gaps = 6/206 (2%)

Query: 17  LYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDMATSGVIVVALT 76
           +Y+DD  MV++KPS +LSVPG+ + H DSV+TR+    P+   +HRLD  TSG++V  L+
Sbjct: 10  IYRDDDFMVIHKPSDILSVPGKGDLH-DSVLTRLVAIEPRTLLIHRLDRDTSGILVFGLS 68

Query: 77  KAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYETGKPAQ 136
           K  +  + RQF++R+  K Y A V GH    EG VD+P++ D    P   V     KPA 
Sbjct: 69  KRGQSAIARQFQDRQTSKIYEALVAGHL-EGEGTVDIPVVYDPSRPPLHIVDASHNKPAL 127

Query: 137 TEYEVVEYA---ADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARAMAPRL 193
           T ++ +E+         RV L PITGRSHQLRVHM  LGHPI+GD  YA+PE + + PRL
Sbjct: 128 THWQAIEHFQIQGQPVTRVKLTPITGRSHQLRVHMQYLGHPIVGDTLYAAPE-QLLVPRL 186

Query: 194 LLHAEMLTITHPAYGNSMTFKAPADF 219
            LHA+ L+  HP  G S+TF  P  F
Sbjct: 187 CLHAKQLSFNHPVTGESLTFNCPVPF 212


>UniRef50_A6TAT3 Pseudouridine synthase n=57 Tax=Bacteria RepID=A6TAT3_KLEP7
          Length = 263

 Score =  255 bits (653), Expect = 8e-67,   Method: Composition-based stats.
 Identities = 85/222 (38%), Positives = 120/222 (54%), Gaps = 10/222 (4%)

Query: 8   PPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDMAT 67
           PP    + +LYQD+H++++NKP+GLLS+ G+   + DSV  R+ + YP    VHRLD  T
Sbjct: 42  PPCREQITLLYQDEHLVLINKPAGLLSLSGKDPRNLDSVHHRLVQRYPGCTLVHRLDFGT 101

Query: 68  SGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKV 127
           SG++V+A  K     L +QF +R   K Y A + GH +  EG+V+  +  D    P+  +
Sbjct: 102 SGLMVIARNKGINALLCQQFSQRTVDKVYTALLCGHLAEDEGIVEAAIAKDPARFPRMAL 161

Query: 128 CYETGKPAQTEYEVVEYAAD--------NTARVVLKPITGRSHQLRVHMLALGHPILGDR 179
           C   GKPA++ Y V++               RV L P TGR+HQLR+H   LG+PILG  
Sbjct: 162 CARHGKPARSRYRVIDRLYQAREGERALALTRVTLTPETGRTHQLRIHCQLLGYPILGCD 221

Query: 180 FYASPE--ARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
            Y   E      APRL+LHA  L   HP     M  +  + F
Sbjct: 222 LYGGRELPGTEQAPRLMLHASELRFVHPVSHEPMHIQQASPF 263


>UniRef50_D1PU24 Pseudouridine synthase n=1 Tax=Prevotella bergensis DSM 17361
           RepID=D1PU24_9BACT
          Length = 421

 Score =  255 bits (652), Expect = 1e-66,   Method: Composition-based stats.
 Identities = 97/216 (44%), Positives = 126/216 (58%), Gaps = 18/216 (8%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAE---SVHRLDMA 66
           +   L I+Y+DD + VV+KP+G+LSVPG+    ++SV+  ++R  P A     VHRLDMA
Sbjct: 218 ETHELKIVYEDDTLCVVDKPAGMLSVPGKG--CRESVLDVMRRRCPDATGALVVHRLDMA 275

Query: 67  TSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQK 126
           TSG++VVA T  A REL+RQF  R  +K+YVA +   P   +G + LPL  D  +RP+Q 
Sbjct: 276 TSGLMVVAKTAEAYRELQRQFATRSVRKRYVAILSRQPREPKGEIALPLRPDLDDRPRQV 335

Query: 127 VCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLA---LGHPILGDRFYAS 183
           V    GKPA T YE+++       RV L P TGR+HQLRVH      L  PI GD  Y  
Sbjct: 336 VDSVYGKPALTHYEIID-----GCRVALYPRTGRTHQLRVHCAHRDGLDSPIKGDELYGR 390

Query: 184 PEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
                 A RL LHAE L   HPA G  + F + A F
Sbjct: 391 R-----AERLYLHAEWLAFRHPATGEEVEFTSVAPF 421


>UniRef50_B8DF66 Pseudouridine synthase n=18 Tax=Listeria RepID=B8DF66_LISMH
          Length = 289

 Score =  255 bits (652), Expect = 1e-66,   Method: Composition-based stats.
 Identities = 74/217 (34%), Positives = 111/217 (51%), Gaps = 12/217 (5%)

Query: 8   PPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ------AESVH 61
           P  E  L I+Y+DD ++VVNKP  + +         D+    +Q    +      A +VH
Sbjct: 72  PTYEYDLEIIYEDDFLLVVNKPVDMKTH-ANDSYETDTCANAVQYYLEKTGQDANALAVH 130

Query: 62  RLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPN 121
           RLD  TSG+++ A  K A   L  Q   R   + Y+A V G        ++ P+  D  +
Sbjct: 131 RLDQTTSGLVLFAKNKLAIAGLSWQMENRAIHRTYLAAVDGTWGLVMQTINKPIGEDRHH 190

Query: 122 RPKQKVCYETGKPAQTEYEVVEYAAD-NTARVVLKPITGRSHQLRVHMLALGHPILGDRF 180
             ++++    G+PA T  +V+E   + NT+ V  +  TGR+HQ+RVH+  +GHPI+GD  
Sbjct: 191 GSRRQI-SPYGQPAVTHVKVLENDNEKNTSLVECQIETGRTHQIRVHLSGIGHPIIGDTL 249

Query: 181 YASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPA 217
           Y        A R++LHAE L + HP  G  M F APA
Sbjct: 250 YGGS---PRANRIMLHAEKLHLNHPFKGKEMNFSAPA 283


>UniRef50_B7HGW1 Pseudouridine synthase n=52 Tax=Bacillales RepID=B7HGW1_BACC4
          Length = 297

 Score =  254 bits (651), Expect = 1e-66,   Method: Composition-based stats.
 Identities = 70/218 (32%), Positives = 114/218 (52%), Gaps = 13/218 (5%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ------AESVHRL 63
           ++  L I+Y+DD ++++NK + + ++P R E    SV   +   Y +         V RL
Sbjct: 78  EDIPLCIIYEDDAVLIINKEANMSTIPSR-EHPAGSVANALLSHYDKQHLASTVHIVTRL 136

Query: 64  DMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRP 123
           D  TSG++++A  +     L +Q +++  K+ Y A V G     EG++D P+     +  
Sbjct: 137 DRDTSGLMLIAKNRFVHHLLSKQHQQKAVKRTYEAIVHGKIVEREGMIDAPIGRKSDSII 196

Query: 124 KQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYAS 183
           ++ VC E G+ A T ++V++     T  V L+  TGR+HQ+RVHM  +GHP+LGD  Y  
Sbjct: 197 ERTVC-EDGQRAVTHFKVIDSTYHKT-HVALELETGRTHQIRVHMAHVGHPLLGDSLYGG 254

Query: 184 PEARAMAPRLLLHAEMLTITHPAYGNSMTFK--APADF 219
              R    R  LH++ LT  HP     M+F    P+D 
Sbjct: 255 R--RDEMKRQALHSKSLTFYHPILEKEMSFTIKLPSDM 290


>UniRef50_D0MK65 Pseudouridine synthase n=1 Tax=Rhodothermus marinus DSM 4252
           RepID=D0MK65_RHOM4
          Length = 235

 Score =  254 bits (651), Expect = 1e-66,   Method: Composition-based stats.
 Identities = 71/207 (34%), Positives = 103/207 (49%), Gaps = 3/207 (1%)

Query: 12  PWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDMATSGVI 71
             L ILY+DD ++ V+KP GL ++P R      +          +   VHRLD   SGV+
Sbjct: 1   MELPILYEDDDLLAVHKPEGLAAIPERDPSRPSARRLLEAARGERLWVVHRLDKEASGVL 60

Query: 72  VVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYET 131
           + A    A R +   F +R+ +K Y A V G   P +G +  P+        +  V  E 
Sbjct: 61  LFARNAEAHRYMNTLFEQRQVRKVYRALVHGRLEPGQGQIRAPI--RMYGSGRMGVDPER 118

Query: 132 GKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARAMAP 191
           GKP++T Y V+EY  +  + +   P+TGR HQ+RVH   +GHPI+GD  Y     +   P
Sbjct: 119 GKPSETRYRVLEYLDEAYSLIEALPLTGRRHQIRVHCYHIGHPIVGDPRYGDRSVQQRYP 178

Query: 192 RLLLHAEMLTITHPAYGNSMTFKAPAD 218
           RL+LHA  +   HP  G  +   AP  
Sbjct: 179 RLMLHALSIRFRHP-NGQELEIVAPVP 204


>UniRef50_A5VJ18 Pseudouridine synthase, RluA family n=13 Tax=Lactobacillus
           RepID=A5VJ18_LACRD
          Length = 301

 Score =  254 bits (651), Expect = 1e-66,   Method: Composition-based stats.
 Identities = 66/216 (30%), Positives = 106/216 (49%), Gaps = 11/216 (5%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQA-------ESVHR 62
            E  + I+Y+D   +++NKP+G+ +VP       DS++ R++  Y +            R
Sbjct: 74  SEAPIDIIYEDQDFLIMNKPAGVATVPAHNVPVADSLVNRVKGYYKRQNYENQVTHVATR 133

Query: 63  LDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNR 122
           LD  TSG++V    + A   L  Q ++   KK Y+A + G      G +D P+  D  + 
Sbjct: 134 LDRDTSGLVVFPKHRFAHAVLDEQLKKHLVKKNYLALIKGKVPAEHGYIDAPIQRDPNSF 193

Query: 123 PKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYA 182
            K+ V  E GK + TEY   E      + + ++  TGR+HQ+RVH  +LG P++GD+ Y 
Sbjct: 194 VKRMVGKE-GKASVTEYWRQECNVQ-ASLIKIRLHTGRTHQIRVHFASLGFPLIGDKMYG 251

Query: 183 SPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
             E   +  R  LH   L+   P  G ++T  AP  
Sbjct: 252 --EESGLIARQALHCYWLSFYSPFKGKNITVSAPLP 285


>UniRef50_Q31NG5 Pseudouridine synthase n=2 Tax=Synechococcus elongatus
           RepID=Q31NG5_SYNE7
          Length = 543

 Score =  254 bits (651), Expect = 1e-66,   Method: Composition-based stats.
 Identities = 86/221 (38%), Positives = 118/221 (53%), Gaps = 15/221 (6%)

Query: 8   PP---QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQA---ESVH 61
           PP   +   L ILY+D  ++ + KP+GLLSVPG     + S +  +++ +P       VH
Sbjct: 329 PPSSDEPLELPILYEDADLLAIIKPAGLLSVPGTRGLQQASAIQLLRQQFPDLPTYCVVH 388

Query: 62  RLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPN 121
           RLD ATSG+++VA  +  +  L  QFR R+  K Y A + G P    G +DLPL  DW  
Sbjct: 389 RLDQATSGILLVARNRPTQVALFEQFRRRQVHKVYEALLEGQPDCTAGTIDLPLRPDWTR 448

Query: 122 RPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLA---LGHPILGD 178
           RP Q V  + G+PA T Y  ++   D   R+ L+PITGR+HQLRVHM     LG PILGD
Sbjct: 449 RPYQLVDRDRGRPALTYYRCIDQTGDR-CRMELEPITGRTHQLRVHMAHPEGLGQPILGD 507

Query: 179 RFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
             Y        + RL LHA  +   HP+  + +       F
Sbjct: 508 DLYG-----QSSDRLYLHARSIRFRHPSQLDWIQLTTDTPF 543


>UniRef50_D1N7N8 Pseudouridine synthase, RluA family n=1 Tax=Victivallis vadensis
           ATCC BAA-548 RepID=D1N7N8_9BACT
          Length = 323

 Score =  254 bits (651), Expect = 1e-66,   Method: Composition-based stats.
 Identities = 77/222 (34%), Positives = 107/222 (48%), Gaps = 18/222 (8%)

Query: 13  WLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP-----------QAESVH 61
              ILY+DD ++V++KP+G++  P        +V+  +   YP           +   VH
Sbjct: 82  EFPILYEDDVMLVIDKPAGVVVHPAAGNPTG-TVVNALLGRYPQLAEQLACTTSRPGIVH 140

Query: 62  RLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPN 121
           RLD  TSG + VA T  A+ +L   F  RE +K Y+A   G P    G +   +     +
Sbjct: 141 RLDKDTSGCLAVAKTANAQFKLSTAFAGRETRKTYLAITRGVPIRRSGELSTLIGRHPVS 200

Query: 122 RPKQKVCYETGKPAQTEYEVVEYAAD----NTARVVLKPITGRSHQLRVHMLALGHPILG 177
           R K  V    GK A T Y V EY           + ++ +TGR+HQ+RVH+ +LG P+LG
Sbjct: 201 RQKMAVVERNGKLAITRYRV-EYTGMLDGVEIGVLAVRILTGRTHQIRVHLASLGVPVLG 259

Query: 178 DRFYAS-PEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           D  Y     A A   R LLHA  L + HPA G  M F AP  
Sbjct: 260 DAVYGGARTAVAGVERQLLHAWKLCVPHPATGTPMEFTAPPP 301


>UniRef50_A5IBH6 Pseudouridine synthase n=6 Tax=Legionella RepID=A5IBH6_LEGPC
          Length = 321

 Score =  254 bits (651), Expect = 1e-66,   Method: Composition-based stats.
 Identities = 70/234 (29%), Positives = 109/234 (46%), Gaps = 22/234 (9%)

Query: 5   NYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR-----DYPQAES 59
           N   P+   + I+Y+D  ++VVNKP+GL+  PG   +    V   +         P+A  
Sbjct: 78  NLCKPENIPIQIIYEDSEVIVVNKPAGLVVHPGAGNKEHTLVNALLHHCPELQLLPRAGI 137

Query: 60  VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDW 119
           +HRLD  T+G+++VA    +   L RQ + RE K+ Y+  V G+     G +D       
Sbjct: 138 IHRLDKDTTGLLIVAKNLISHTSLIRQMQNREIKRHYLTLVHGYVISG-GTIDTGFGRHP 196

Query: 120 PNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDR 179
            NR K  V  + G+ A T Y + ++  D    + +  +TGR+HQ+RVHM  + HP++GD+
Sbjct: 197 KNRLKMAV-TDFGRQAVTHYNINKHYKD-FTLLNVSLMTGRTHQIRVHMNYINHPVVGDQ 254

Query: 180 FYASP------------EARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
            Y                      R  LHA  ++  HP     +T  A  P DF
Sbjct: 255 LYGGRMKFPPNADEAILSVLKQFKRQALHACSISFCHPVKNTEITLNALLPDDF 308


>UniRef50_Q0BWH2 Pseudouridine synthase n=3 Tax=Alphaproteobacteria
           RepID=Q0BWH2_HYPNA
          Length = 341

 Score =  254 bits (651), Expect = 1e-66,   Method: Composition-based stats.
 Identities = 67/249 (26%), Positives = 101/249 (40%), Gaps = 40/249 (16%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR---------DYPQAESV 60
           +   L IL++D H++++NK +G+   P    +    V   +              +   V
Sbjct: 77  EAIPLEILFEDAHLVILNKAAGMAVHPAPGSQTGTLVNALLHHCQGQLSGIGGVERPGIV 136

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLD  TSGV+V A T++A   L   F   +  + Y A   G P P  G ++  +     
Sbjct: 137 HRLDKLTSGVMVAAKTESAHTGLAALFERHDIDRVYRAVTRGAPRPLSGTIEAAIARSES 196

Query: 121 NRPKQKV----CYETGKPAQTEYEVVEYAADN--------TARVVLKPITGRSHQLRVHM 168
           +R K  V         + A T Y+ VE              A +  +  TGR+HQ+RVHM
Sbjct: 197 DRKKMSVHRNPDSPAARHAVTHYKAVETFGYKDRATRLPAAALLECRLETGRTHQIRVHM 256

Query: 169 LALGHPILGDRFYA-----------SPEARA--------MAPRLLLHAEMLTITHPAYGN 209
              G P++GD  Y              EAR            R  LHA +L   HP  G 
Sbjct: 257 AHSGAPLIGDPVYGRQAGIMAWKAPGSEARYDKALAAARAFSRQALHAAVLGFVHPITGE 316

Query: 210 SMTFKAPAD 218
           ++ ++AP  
Sbjct: 317 TLRYEAPLP 325


>UniRef50_C0Z877 Pseudouridine synthase n=1 Tax=Brevibacillus brevis NBRC 100599
           RepID=C0Z877_BREBN
          Length = 310

 Score =  254 bits (650), Expect = 1e-66,   Method: Composition-based stats.
 Identities = 70/211 (33%), Positives = 106/211 (50%), Gaps = 8/211 (3%)

Query: 12  PWLVILYQDDHIMVVNKPSGLLSVP----GRLEEHKDSVMTRIQRDYPQAESVHRLDMAT 67
           P + ILY+DDH+++ NKP+G++  P         H  + +   + +      VHRLD  T
Sbjct: 92  PSIDILYEDDHLLIANKPAGMMVHPIKQETDTLVHALAAVLAARGEQTSVHPVHRLDKDT 151

Query: 68  SGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKV 127
           SG I+VA +    +   R  RE    ++Y+A   G  S   G +D P+  D  +  K++V
Sbjct: 152 SGAILVAKSSYGHQLADRLLREGGIHREYLAVASGVLSEGAGTIDAPIGRDARHPTKRRV 211

Query: 128 CYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEAR 187
             E+G PA T YEV +  ++      +   TGR+HQ+RVH   +GHP+ GD  Y    AR
Sbjct: 212 V-ESGDPAITHYEV-QQTSEEMTLARVWLETGRTHQIRVHFAHIGHPLAGDTMYGG--AR 267

Query: 188 AMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
            +  R  LHA  L+  HP     +  +AP  
Sbjct: 268 GLLRRQALHASKLSFLHPLLEKEIVVEAPIP 298


>UniRef50_C0MA80 Pseudouridine synthase n=6 Tax=Streptococcus RepID=C0MA80_STRE4
          Length = 300

 Score =  254 bits (650), Expect = 2e-66,   Method: Composition-based stats.
 Identities = 66/206 (32%), Positives = 102/206 (49%), Gaps = 12/206 (5%)

Query: 13  WLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDY-------PQAESVHRLDM 65
            L I+Y+D+H +++NKP+G  S+P  +  H +++   I+  Y        Q   V RLD 
Sbjct: 75  DLDIVYEDEHFLILNKPAGYASIPSAI--HSNTIANFIKAYYIKQDYPNKQVHIVTRLDR 132

Query: 66  ATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPS-PAEGLVDLPLICDWPNRPK 124
            TSG+++ A    A   L +Q ++R   K+Y A V G    P +G +  P+     +   
Sbjct: 133 DTSGLMLFAKHGYAHARLDKQLQQRAINKRYYALVCGQERLPDQGEIIAPIGR-TDDSII 191

Query: 125 QKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASP 184
            +     GK A+T Y+V+    +N + V +   TGR+HQ+RVH   LG P+LGD  Y   
Sbjct: 192 TRTVTPKGKYAKTSYKVIARYPENVSLVDITLHTGRTHQIRVHFAHLGFPLLGDDLYGGR 251

Query: 185 EARAMAPRLLLHAEMLTITHPAYGNS 210
               M  R  LH   L+ THP   + 
Sbjct: 252 LDLGMT-RQALHCHHLSFTHPFTESR 276


>UniRef50_B6J6C4 Pseudouridine synthase n=7 Tax=Coxiella burnetii RepID=B6J6C4_COXB1
          Length = 327

 Score =  254 bits (649), Expect = 2e-66,   Method: Composition-based stats.
 Identities = 66/227 (29%), Positives = 108/227 (47%), Gaps = 20/227 (8%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRD-----YPQAESVHRL 63
           PQ   L ++Y+D+ ++V+NKP GL+  PG     +  +   +  D      P+A  +HRL
Sbjct: 84  PQPIPLDVIYEDETLLVINKPVGLIVHPGAGVRDQTLINALLHYDPSLSVVPRAGIIHRL 143

Query: 64  DMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRP 123
           D  TSG++++A T A+   L +  + R+  ++Y A V G        ++ P+     +R 
Sbjct: 144 DKDTSGLLLIARTLASHHALIKAMKARQIVREYEAIVKGVLISGR-TIEAPVGRHPIHRT 202

Query: 124 KQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYAS 183
           +  V  E G+PA T + +++    +T  + ++  TGR+HQ+RVHM  + HP+ GD  Y S
Sbjct: 203 RMAVV-EFGRPAITHFRIIKRYRAHT-HIRVQLETGRTHQIRVHMAHIHHPLAGDPVYGS 260

Query: 184 ------------PEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
                         A     R  LH   L  +HP     M   AP  
Sbjct: 261 HVGIPVHLSDPLQTALKTLKRQALHGATLQFSHPVDQRPMACHAPLP 307


>UniRef50_P59838 Ribosomal large subunit pseudouridine synthase D n=3
           Tax=Gammaproteobacteria RepID=RLUD_BLOFL
          Length = 321

 Score =  253 bits (648), Expect = 2e-66,   Method: Composition-based stats.
 Identities = 77/231 (33%), Positives = 117/231 (50%), Gaps = 24/231 (10%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP-------QAESVH 61
           PQ   L I+Y+D+ I+V+NK S ++  PG +  ++ +V+  +   YP       QA  V 
Sbjct: 81  PQNIPLNIIYEDNDILVINKASNMVVHPG-IGHYQGTVLNALLYRYPSILKISKQAGIVQ 139

Query: 62  RLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPN 121
           RLD  T+G++++A T +A   L R F+ R+  K+Y A V+G  +   G+V+ P+   +  
Sbjct: 140 RLDKDTTGLMIIAKTVSAYDNLLRSFKLRKVVKEYDAIVYGKFTSNAGVVNQPMRRHFAK 199

Query: 122 RPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFY 181
           R    V Y TGK A T Y VVE    + +RV +   TGR+HQ+RVHM  + HP++GD+ Y
Sbjct: 200 RTFMSVHY-TGKSAVTYYSVVEEFKAH-SRVRINLKTGRTHQIRVHMAYINHPLVGDQKY 257

Query: 182 ASPEARAMAP--------------RLLLHAEMLTITHPAYGNSMTFKAPAD 218
               +                   R  LHA  L + HP     M + AP  
Sbjct: 258 KGNFSVFDIKKMSDELNNYLLDFNRQALHACTLQLLHPITQVQMKWNAPLP 308


>UniRef50_O31613 Uncharacterized RNA pseudouridine synthase yjbO n=53
           Tax=Bacillaceae RepID=YJBO_BACSU
          Length = 283

 Score =  253 bits (648), Expect = 3e-66,   Method: Composition-based stats.
 Identities = 73/215 (33%), Positives = 104/215 (48%), Gaps = 11/215 (5%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDY------PQAESVHRL 63
           +   L ILY+D+H++V+NK   + S+P R      S+   I   Y           V RL
Sbjct: 62  EPVPLDILYEDEHVLVINKQPYVSSIPSREHPSG-SIANGIIDHYQTTGVRATVHLVTRL 120

Query: 64  DMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRP 123
           D  TSG+++VA  + A   L    +    K++Y A V G  +  EG VD P+    P+  
Sbjct: 121 DRDTSGIMLVAKHRFAHSILSSAQKNGLVKRRYAAVVHGRMAQMEGTVDAPIGRH-PDSI 179

Query: 124 KQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYAS 183
            ++     G+ A T + V   A D+   V L+  TGR+HQ+RVHM  LGHP+ GD  Y  
Sbjct: 180 IERTVTPDGQKAVTHFYVT-CANDDMTSVALQLETGRTHQIRVHMSYLGHPLCGDTLYGG 238

Query: 184 PEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
              R    R  LH+E L+  HP    +M F AP  
Sbjct: 239 --TRQEIGRQALHSEHLSFIHPLTQENMRFHAPLP 271


>UniRef50_D1CBT6 Pseudouridine synthase n=1 Tax=Thermobaculum terrenum ATCC BAA-798
           RepID=D1CBT6_THET1
          Length = 313

 Score =  253 bits (647), Expect = 4e-66,   Method: Composition-based stats.
 Identities = 71/218 (32%), Positives = 109/218 (50%), Gaps = 13/218 (5%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP--------QAESV 60
           P    L ++Y+DD I+V++KP+G++  P     + ++++  +   YP        +   V
Sbjct: 86  PSYVDLRVVYEDDKIIVIDKPAGMVVHPSPGH-YDNTLVNALIARYPDLLKQPTDRPGIV 144

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLD  TSG+I+VA        L+ Q + R+  K+Y     G   P EG ++ P+  D  
Sbjct: 145 HRLDKDTSGLIIVARDLDTLNYLQGQMKARKIFKEYTLLCCGALDPPEGRIEAPIGRDLR 204

Query: 121 NRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRF 180
           +R K  V    GK A TEY  ++     T  +  +PITGR+HQ+RVH  A+GHPI GD  
Sbjct: 205 DRTKMSVI-AGGKEAVTEYSTIQSLGKYTLAIA-RPITGRTHQIRVHFAAIGHPIAGDPI 262

Query: 181 YASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           Y +     +  R  LHA  L +  P  G    + +P  
Sbjct: 263 YGNCRLEGL-NRQFLHASRLGVVMP-NGEYKEWHSPLP 298


>UniRef50_C1CWT3 Pseudouridine synthase n=1 Tax=Deinococcus deserti VCD115
           RepID=C1CWT3_DEIDV
          Length = 321

 Score =  252 bits (645), Expect = 5e-66,   Method: Composition-based stats.
 Identities = 73/226 (32%), Positives = 104/226 (46%), Gaps = 19/226 (8%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR------------DYPQA 57
           ++  L ++Y+DD+++ VNKP G+++ P         V   + R               + 
Sbjct: 73  EDLPLDVIYEDDYLIAVNKPPGMVTHPAPGVLSGTLVNALLGRMPLPEQPDYDSEAGYRP 132

Query: 58  ESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAE-GLVDLPLI 116
             VHRLD  TSGVIVVA T  A   L   F++RE +K Y+A   G         V+ P+ 
Sbjct: 133 GIVHRLDKDTSGVIVVAKTVGAHARLAAAFKDRETRKTYLAIAAGQWRADGPARVEAPIG 192

Query: 117 CDWPNRPKQKVCYETGKPAQTEYEVVEYAADN----TARVVLKPITGRSHQLRVHMLALG 172
                R +  V     + AQT +  +    D      A V  +P TGR+HQ+RVH+  LG
Sbjct: 193 RHPVQRQRMTVGGANPREAQTLFTPLAAHPDGHGRTLALVRAQPRTGRTHQIRVHLAHLG 252

Query: 173 HPILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
            PILGD  Y       +  R  LHA  L++ HP  G  +   APA 
Sbjct: 253 SPILGDAVYGRSSETML--RHALHAHFLSVPHPGTGRLLHLHAPAP 296


>UniRef50_UPI00016C3FBA ribosomal large subunit pseudouridine synthase n=1 Tax=Gemmata
           obscuriglobus UQM 2246 RepID=UPI00016C3FBA
          Length = 354

 Score =  252 bits (645), Expect = 7e-66,   Method: Composition-based stats.
 Identities = 72/235 (30%), Positives = 104/235 (44%), Gaps = 26/235 (11%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTR---------IQRDYPQAES 59
           P++  L ILYQD+ + +VNKP+ ++  P +       V                + +A  
Sbjct: 104 PEDIPLDILYQDEWLALVNKPADMVVHPAKGNWSGTLVNALQWHFREHLSTGAGHLRAGI 163

Query: 60  VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDW 119
           VHRLD  TSGVI+VA      R+L  QF  R+  K+YVA   G        ++  L    
Sbjct: 164 VHRLDKDTSGVILVAKDDLTHRDLAMQFESRKVFKEYVAIAAGELERDSDYIEGALKMHP 223

Query: 120 PNRPKQKVCYE-TGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGD 178
            +R K  V  +   K A + YEV+E        V ++P TGR+HQ+RVH+L +G  +L D
Sbjct: 224 YDRLKMIVSTDPDAKHALSYYEVLERFR-GFTLVKVQPRTGRTHQIRVHLLHVGCAVLAD 282

Query: 179 RFYASP---------------EARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           + Y                  E   +  R  LHA  L   HP  G  +  +AP  
Sbjct: 283 KIYGGRAQVKLSEIAPGTPPAEDEVLLGRQALHAFRLRFQHPRTGQWIEAEAPLP 337


>UniRef50_Q6MGX8 Pseudouridine synthase n=1 Tax=Bdellovibrio bacteriovorus
           RepID=Q6MGX8_BDEBA
          Length = 319

 Score =  252 bits (645), Expect = 7e-66,   Method: Composition-based stats.
 Identities = 74/240 (30%), Positives = 99/240 (41%), Gaps = 35/240 (14%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYPQAESV 60
           P +  L +L++D+ ++V+NKP+GL+  P     H   V   I             +   V
Sbjct: 64  PFDLKLDVLFEDEDLIVINKPAGLVVHPAAGHAHDTLVNALIHHTDDLSMKFGEERPGIV 123

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLD  TSG+IV+A    A   L  QF+ER   + Y A   G      G V   L     
Sbjct: 124 HRLDKETSGIIVIAKNDKAHESLTSQFKERSTHRIYYAVCLGTARTLSGSVRSFLARHPV 183

Query: 121 NRPKQKVCYET--------------GKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRV 166
           +R +                     GK A T +EV++      + + LK  TGR+HQ+RV
Sbjct: 184 DRKRYASVLGDDRKPLTDPNDDPGLGKWAVTHFEVLQR-KSGMSYLKLKLETGRTHQIRV 242

Query: 167 HMLALGHPILGDRFYASP------------EARAMAPRLLLHAEMLTITHPAYGNSMTFK 214
           HM   G PI GD  Y +             E     PR LLHA  L  THP     M F 
Sbjct: 243 HMSESGLPIAGDTLYGADRKIKSIEARATQEDLRTLPRFLLHAAELGFTHPRTKERMFFT 302


>UniRef50_D1AV01 Pseudouridine synthase n=2 Tax=Bacteria RepID=D1AV01_STRM9
          Length = 297

 Score =  251 bits (643), Expect = 1e-65,   Method: Composition-based stats.
 Identities = 60/206 (29%), Positives = 102/206 (49%), Gaps = 15/206 (7%)

Query: 17  LYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR---------DYPQAESVHRLDMAT 67
           +Y+D ++ ++NK +G++  P +  E +D+++  I              +   VHRLD  T
Sbjct: 78  VYEDKYLAIINKYAGMVVHPSKGHE-EDTLVNAIMYKIKDLSGINGDLRPGIVHRLDKNT 136

Query: 68  SGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKV 127
           SG+I++A       +L   F+ +E KK Y A V G  +   G ++  +  +  +R K  V
Sbjct: 137 SGLIIIAKDDKTHFKLSEMFKNKEIKKIYYAIVKGKVNKKSGRIETMIGRNPNDRKKMAV 196

Query: 128 CYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEAR 187
             + GK A T +EV++ + +  + + +   TGR+HQ+RVH+     PILGD  Y   +  
Sbjct: 197 V-DNGKLAITNFEVID-SNEKFSLLKVDLETGRTHQIRVHLSHFFFPILGDSVYGRKDE- 253

Query: 188 AMAPRLLLHAEMLTITHPAYGNSMTF 213
               R +LHA ML   HP     +  
Sbjct: 254 --YDRQMLHAYMLNFIHPITLEKIDV 277


>UniRef50_B8FTI5 Pseudouridine synthase n=2 Tax=Desulfitobacterium hafniense
           RepID=B8FTI5_DESHD
          Length = 302

 Score =  251 bits (643), Expect = 1e-65,   Method: Composition-based stats.
 Identities = 67/219 (30%), Positives = 100/219 (45%), Gaps = 9/219 (4%)

Query: 5   NYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDS----VMTRIQRDYPQA-ES 59
           N  P +   L ILY+DD+ + +NKP+G +  P             V   + +   +    
Sbjct: 74  NSIPGENLPLEILYEDDYFIAINKPAGQVVHPTPRYPRGTIGNAVVGYWLAKGEARPFRP 133

Query: 60  VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDW 119
           +HR+D  TSGV+V+   + A +++  Q       K Y   V G     +G +  P+    
Sbjct: 134 IHRIDRNTSGVVVIGKNQFAHQQMAWQHAHGRIHKCYRGIVEGQVMEDQGTIKAPIAL-A 192

Query: 120 PNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDR 179
           P+   Q+     G PA T Y+V+E   D  + +     TGR+HQ+RVH   LGHP+LGD 
Sbjct: 193 PDSFIQRQISPEGSPAVTLYKVLERYQD-ASLLEFILETGRTHQIRVHCQHLGHPLLGDD 251

Query: 180 FYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
            Y    AR    R  LH+ +    HP  G   T +AP  
Sbjct: 252 LYGGNLAR--INRQALHSSIYEFNHPLTGELTTIQAPLP 288


>UniRef50_C6BRU5 Pseudouridine synthase n=1 Tax=Desulfovibrio salexigens DSM 2638
           RepID=C6BRU5_DESAD
          Length = 214

 Score =  251 bits (642), Expect = 1e-65,   Method: Composition-based stats.
 Identities = 91/214 (42%), Positives = 120/214 (56%), Gaps = 11/214 (5%)

Query: 11  EPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAE---SVHRLDMAT 67
           E  L I+Y D  I+VVNKPSGLLSVPGR  E++D V+TR+Q+ +P+     +VHRLDM T
Sbjct: 4   EKLLDIVYADRKIVVVNKPSGLLSVPGRGPENQDCVVTRVQKMFPECRKFPAVHRLDMDT 63

Query: 68  SGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKV 127
           SG++V+ LT  A REL  QF++R+ KK+Y A + G      G++++    D  NRP Q  
Sbjct: 64  SGLLVLGLTARAVRELMEQFQKRQVKKRYEALLEGIVKEDSGVIEMAFRLDPYNRPYQVY 123

Query: 128 CYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLA---LGHPILGDRFYASP 184
               GK   T +  +    +   RV   P+TGR+HQLRVH      LG PI+GDR Y S 
Sbjct: 124 DPIHGKLGITHWRKLG-VENGMTRVEFTPLTGRTHQLRVHSAHPQGLGCPIVGDRLYGSG 182

Query: 185 EARAMAPRLLLHAEMLTITHPAYGNSMTFK-APA 217
                     LHA  L   HP     M F+ AP 
Sbjct: 183 TEPGQLK---LHAGYLCFEHPKTKEKMEFEIAPL 213


>UniRef50_Q8ERS8 Pseudouridine synthase n=2 Tax=Bacillaceae RepID=Q8ERS8_OCEIH
          Length = 322

 Score =  251 bits (642), Expect = 1e-65,   Method: Composition-based stats.
 Identities = 69/219 (31%), Positives = 108/219 (49%), Gaps = 12/219 (5%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ------AESVHR 62
           P++  L I+Y+D + +VVNKP+G   +P     H +++   +   Y +         V R
Sbjct: 98  PEKLPLDIIYEDAYCLVVNKPAGQACLPSMNHRH-NTLANGLTYYYQKNSIPSTVHIVTR 156

Query: 63  LDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNR 122
           LD+ TSG+++VA  +       R  +E    + Y A V G  SP  G+VD P+     + 
Sbjct: 157 LDVNTSGLVLVAKNQYVHSLFSRMQQEGNINRVYEAIVHGEVSPTSGIVDAPIARKEGSI 216

Query: 123 PKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYA 182
            ++ V    GK A+T Y V+ YA    + V +K  TGR+HQ+RVH   LGH + GD  Y 
Sbjct: 217 IERTVDMRNGKYAKTNYRVL-YADSIASWVEIKLETGRTHQIRVHFQYLGHSLYGDNLYG 275

Query: 183 SPEARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
             +   +  R  LH + +T+ HP     +  +A  P D 
Sbjct: 276 GSKDIML--RQALHCKQITMMHPIKNQPIQLEASLPEDM 312


>UniRef50_Q8K9E9 Ribosomal large subunit pseudouridine synthase D n=4 Tax=Buchnera
           aphidicola RepID=RLUD_BUCAP
          Length = 315

 Score =  250 bits (641), Expect = 2e-65,   Method: Composition-based stats.
 Identities = 66/234 (28%), Positives = 111/234 (47%), Gaps = 23/234 (9%)

Query: 6   YNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRD-----YPQAESV 60
            N PQ   L  +Y+D +I+++NKP GL+  PG   +    +   + R       P+   +
Sbjct: 76  INLPQNIALNTIYEDSNILIINKPPGLVVHPGAGNQDGTILNALLYRYTNISSIPRCGII 135

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLD  TSG++V+A T  +  +L    ++R+  ++Y   + G+     G+V+ P++    
Sbjct: 136 HRLDKDTSGLMVIAKTIFSYNKLVTLLKKRKIIRKYQGIIKGNMISG-GIVNYPIMRHPF 194

Query: 121 NRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRF 180
            R         GK + T Y+++     +T  V  +  TGR+HQ+RVHML +G+P+LGD  
Sbjct: 195 KRICMTTD-SLGKKSITHYKIINRFKFHT-HVSFRLETGRTHQIRVHMLHIGYPLLGDPL 252

Query: 181 YASPE-------------ARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
           Y   +              +    R  LHA+ +   HP     M++ A  P D 
Sbjct: 253 YGGIDYGCNYFQENRNIYRKFNLFRQALHADYIEFIHPFTQKVMSWSASLPQDM 306


>UniRef50_B7I1Q3 Dual specificity pseudouridine synthase n=17 Tax=Acinetobacter
           RepID=B7I1Q3_ACIB5
          Length = 229

 Score =  250 bits (641), Expect = 2e-65,   Method: Composition-based stats.
 Identities = 92/202 (45%), Positives = 129/202 (63%), Gaps = 2/202 (0%)

Query: 19  QDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDMATSGVIVVALTKA 78
           +DD ++VV+KP+GLLSV GRL EH DS   R+   +P A+  HRLDMATSG+++ A  + 
Sbjct: 29  EDDDLIVVDKPAGLLSVMGRLPEHHDSAYLRVLEKFPLAKVTHRLDMATSGLLMFAKHRD 88

Query: 79  AERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYETGKPAQTE 138
           AE  + + F+ R  KK Y+A V G     EG V++PLI DW NRP+Q V +E GK A+T 
Sbjct: 89  AEVAVSKMFQARTVKKHYIALVQGQVKQ-EGRVEVPLITDWENRPRQIVHFELGKHAKTL 147

Query: 139 YEVVEY-AADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARAMAPRLLLHA 197
           ++ + Y    + +RV+L+P+TGRSHQLRVHM+ +GHPI+GD+ Y     R    R+ LHA
Sbjct: 148 FQPLVYDETTDQSRVLLEPVTGRSHQLRVHMMHIGHPIMGDKLYHPEPKRFHLNRMALHA 207

Query: 198 EMLTITHPAYGNSMTFKAPADF 219
             L   HP  G  +  ++   F
Sbjct: 208 AYLAFQHPLKGTDVVIESQVPF 229


>UniRef50_Q8ZQ16 Ribosomal large subunit pseudouridine synthase C n=110
           Tax=Gammaproteobacteria RepID=RLUC_SALTY
          Length = 319

 Score =  250 bits (641), Expect = 2e-65,   Method: Composition-based stats.
 Identities = 82/214 (38%), Positives = 109/214 (50%), Gaps = 14/214 (6%)

Query: 16  ILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAE---SVHRLDMATSGVIV 72
           ILY+DDHI+V+NKPSG     G        V+  ++   P+A     VHRLD  TSGV++
Sbjct: 95  ILYEDDHILVLNKPSGTAVHGGSGLSFG--VIEGLRALRPEARFLELVHRLDRDTSGVLL 152

Query: 73  VALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKV-CYET 131
           VA  ++A R L  Q RE+  +K Y+A V G        V  PL+ +     ++ V   + 
Sbjct: 153 VAKKRSALRSLHEQLREKGMQKDYLALVRGQWQSHVKTVQAPLLKNILQSGERIVRVSQE 212

Query: 132 GKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASP------- 184
           GKP++T ++V E  A     V   P+TGR+HQ+RVH    GHPI  D  Y          
Sbjct: 213 GKPSETRFKVEERYA-FATLVRCSPVTGRTHQIRVHTQYAGHPIAFDDRYGDREFDQQLT 271

Query: 185 EARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           EA     RL LHA  L  THP  G  M  +AP D
Sbjct: 272 EAGTGLKRLFLHAAALKFTHPGTGEVMRIEAPMD 305


>UniRef50_B2KBB0 Pseudouridine synthase n=1 Tax=Elusimicrobium minutum Pei191
           RepID=B2KBB0_ELUMP
          Length = 299

 Score =  250 bits (640), Expect = 2e-65,   Method: Composition-based stats.
 Identities = 72/223 (32%), Positives = 114/223 (51%), Gaps = 27/223 (12%)

Query: 16  ILYQDDHIMVVNKPSGLLSVPGRLEEHKD---------SVMTRIQRDYP--------QAE 58
           I+++D ++ V+NKPSG+L  P      ++         ++++ I  + P        +A 
Sbjct: 77  IIFEDKNMFVINKPSGMLVHPQSPVWEENPAAAFIGEETLVSLILANPPKNFEKGITRAG 136

Query: 59  SVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICD 118
            VHRLD  TSGV+++A     +  +   F  RE  K Y A V G     +G++++P+   
Sbjct: 137 LVHRLDKDTSGVMIIAKNSKTQDAMVEMFANREMHKTYEAIVCGVVPDDKGIINVPIGRV 196

Query: 119 WPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGD 178
              + K     E G+ A TEY V++   +  + + L P+TGR++QLRVHM  LG+P+LGD
Sbjct: 197 TGGKIK---ASELGREAVTEYSVLQR-KETVSLMKLHPVTGRTNQLRVHMSWLGYPVLGD 252

Query: 179 RFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
             Y      A APRL+LH++     HP     + F    P DF
Sbjct: 253 WLYKG----ATAPRLMLHSKSAEFEHPFTSKPVKFTVAPPKDF 291


>UniRef50_Q14NK8 Probable pseudouridine synthase d protein n=1 Tax=Spiroplasma citri
           RepID=Q14NK8_SPICI
          Length = 306

 Score =  250 bits (640), Expect = 2e-65,   Method: Composition-based stats.
 Identities = 63/221 (28%), Positives = 106/221 (47%), Gaps = 11/221 (4%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP--------QAESV 60
           P    L ILY+D ++MV++KP+ L+  P    ++   V   + R           +   V
Sbjct: 76  PLAIPLTILYEDSYLMVIDKPNNLVVHPAPGHQNDTLVNALLARGVQWSTASGEQRPGIV 135

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HR+D  T+G +++A       +L++Q + ++ +++Y+A V G        +D P+  D  
Sbjct: 136 HRIDRQTTGTLIIAKNDVVHHQLQQQIQTKQLQRRYLALVHGQIIENRAKIDAPIGRDPN 195

Query: 121 NRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRF 180
           NR K  V  +  K A T   V+E   D    +  +  +GR+HQ+R H+  + HPI+GD  
Sbjct: 196 NRKKMVVTAKNSKKALTNIVVIERFND-YTYIECELESGRTHQIRAHLKYINHPIVGDPL 254

Query: 181 YASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
           Y +   +  +    LHA  L   HP    S+T  A  P +F
Sbjct: 255 YGTVADKKESFGQYLHAYQLRFIHPVTKESLTITAALPQEF 295


>UniRef50_A6FXR5 Pseudouridine synthase n=1 Tax=Plesiocystis pacifica SIR-1
           RepID=A6FXR5_9DELT
          Length = 509

 Score =  250 bits (640), Expect = 3e-65,   Method: Composition-based stats.
 Identities = 88/251 (35%), Positives = 127/251 (50%), Gaps = 45/251 (17%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR---------------- 52
           P +    ++Y+DD ++VV+KP G+LSVPGR    +DSV  R++                 
Sbjct: 264 PDDAP-RVVYEDDDLLVVDKPPGMLSVPGRGPRRRDSVEYRLKARANPDAIEAAVAAQSK 322

Query: 53  -----------------DYPQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQ 95
                            D      VHRLD+ATSG+++ A  + A   L+RQF  R+  K+
Sbjct: 323 SKPPAGSEARTAAGPRLDQLWPRLVHRLDLATSGLLIAAKHREAYVALQRQFSSRQIGKR 382

Query: 96  YVARVWGHPSP---AEGLVDLPLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADN-TAR 151
           YVA V G         G ++LPL  D  +RP+QKV    GK A+T ++++ +  ++  +R
Sbjct: 383 YVALVRGPLPDALGEGGEIELPLARDLDDRPRQKVDRREGKVARTRWQLLAHEPEHAASR 442

Query: 152 VVLKPITGRSHQLRVHMLA---LGHPILGDRFYASPEARAMAPRLLLHAEMLTITHPAYG 208
           V L P TGR+HQLR+H      L  P++GD  Y   E      RL+LHAE LT  HP  G
Sbjct: 443 VALYPHTGRTHQLRLHAAHPEGLDAPLVGDLLYGYGEG----ARLMLHAERLTFLHPTRG 498

Query: 209 NSMTFKAPADF 219
             M  ++P  F
Sbjct: 499 EPMELRSPCPF 509


>UniRef50_A4J479 Pseudouridine synthase n=1 Tax=Desulfotomaculum reducens MI-1
           RepID=A4J479_DESRM
          Length = 303

 Score =  250 bits (639), Expect = 3e-65,   Method: Composition-based stats.
 Identities = 64/213 (30%), Positives = 109/213 (51%), Gaps = 11/213 (5%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQA------ESVHR 62
           P+   L ILY+D H++ VNKP G+L  P    E   ++   +   + Q         VHR
Sbjct: 79  PERMELNILYEDAHLLAVNKPPGMLVHP-LTNETSGTLANGVLYHWLQQGTIDRFRPVHR 137

Query: 63  LDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNR 122
           LD  TSG++++A     +++L+ Q ++ +  ++Y+A V G   P +G++  P+  +  + 
Sbjct: 138 LDRNTSGIVLIARNPYVQQQLQIQMKQGQFVRRYLALVKGKVQPEQGVIQAPIALEEGSF 197

Query: 123 PKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYA 182
            K+ +    GK A + Y+V+    +  + V ++  TGR+HQ+RVHM  +GHP+LGD  Y 
Sbjct: 198 IKRMI-SPAGKEAISHYQVLRTF-NQASLVRVELETGRTHQVRVHMAHMGHPLLGDSLYG 255

Query: 183 SPEARAMAPRLLLHAEMLTITHPAYGNSMTFKA 215
              +     R  LH   L   HP  G+ +    
Sbjct: 256 GDTSN--IKRQALHCAYLAFNHPVQGSRIKISC 286


>UniRef50_B0K860 Pseudouridine synthase n=11 Tax=Thermoanaerobacterales
           RepID=B0K860_THEP3
          Length = 285

 Score =  250 bits (639), Expect = 3e-65,   Method: Composition-based stats.
 Identities = 66/221 (29%), Positives = 111/221 (50%), Gaps = 15/221 (6%)

Query: 4   ENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ------A 57
           ++   P++  L I Y+D+ I++VNKP+ ++  P +  +   ++   +   + +       
Sbjct: 64  DSNIAPEKLDLDICYEDEEILIVNKPANMVVHPTKRYQSG-TLANGVAWYFKEKGLKALI 122

Query: 58  ESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLIC 117
             V+RLD  TSG++V A     +  L+     +   K Y A V G     EG +DLP+  
Sbjct: 123 RPVNRLDRGTSGLVVFAKRPFMQYYLQII---KPMTKLYFAVVEGKM-EGEGRIDLPISR 178

Query: 118 DWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILG 177
              +  ++ V  E G  A T Y+VV+ ++   + + +K  TGR+HQ+RVH+  +GHPI+G
Sbjct: 179 KPQSGIERMV-SEEGDRAITNYKVVK-SSKRFSLLKVKIETGRTHQIRVHLSHIGHPIVG 236

Query: 178 DRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           D  Y S +      R  LHA  LT  HP    S++  +P  
Sbjct: 237 DTLYGSSDD--YIKRQALHAYRLTFVHPLEEKSISVYSPLP 275


>UniRef50_C5RBB6 23S rRNA pseudouridylate synthase RluD n=1 Tax=Weissella
           paramesenteroides ATCC 33313 RepID=C5RBB6_WEIPA
          Length = 305

 Score =  249 bits (638), Expect = 4e-65,   Method: Composition-based stats.
 Identities = 67/216 (31%), Positives = 106/216 (49%), Gaps = 11/216 (5%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ-------AESVHR 62
            +  + ILY+D++ +VV+K +G+ SVPG+ +  + +++ R++               V R
Sbjct: 75  SDLPIKILYEDENWLVVDKVAGVTSVPGKADR-ETTMVNRVKGYLISEGAEDLVPHVVTR 133

Query: 63  LDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNR 122
           LD  TSGV ++A  + A   L +Q +     K+Y A V G      G +D P+     N 
Sbjct: 134 LDRFTSGVALLAKHRFAHGLLDKQLQTHTVDKRYYAIVDGIVPDDHGFIDAPIGR-MDND 192

Query: 123 PKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYA 182
             ++     G+P+QTEY VV    + T  V ++  TGR+HQ+RVH   +GHP++GD  Y 
Sbjct: 193 FIRREVRADGRPSQTEYWVVNRMPNQT-LVKVQLHTGRTHQIRVHFKYIGHPLIGDEIYG 251

Query: 183 SPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
            P  R    R  LHA  L    P        ++P  
Sbjct: 252 GPMDRG-IERQALHAYWLEFYDPFSEIKRHIQSPLP 286


>UniRef50_B4U613 Pseudouridine synthase, RluA family n=1 Tax=Hydrogenobaculum sp.
           Y04AAS1 RepID=B4U613_HYDS0
          Length = 308

 Score =  249 bits (638), Expect = 4e-65,   Method: Composition-based stats.
 Identities = 70/220 (31%), Positives = 106/220 (48%), Gaps = 17/220 (7%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYPQAESVH 61
           Q+  + ILY+D+ + VV KPSG+ S  G   +    V   + +           +   VH
Sbjct: 75  QDIHIDILYEDNDLAVVVKPSGMPSHTGPGHDENTLVNALLAKFGDLSVIGGVERPGIVH 134

Query: 62  RLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPN 121
           RLD  T G++V+A    + ++L   F+ +E  K Y A V+G     E  ++  +     N
Sbjct: 135 RLDRYTHGLMVIAKNDVSHQKLSLMFKNKEVDKHYKAIVYGISRFKEQTIETFIRRHPTN 194

Query: 122 RPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFY 181
           R K +V  E GK A T+Y  +E    N + + +K  TGR+HQ+RVHM  +GHPI+GD  Y
Sbjct: 195 RLKFEVANE-GKLAITKYS-LEKPLKNASLLDIKIYTGRTHQIRVHMSYIGHPIVGDTLY 252

Query: 182 ASPEA-------RAMAPRLLLHAEMLTITHPAYGNSMTFK 214
               +         +  R LL A  L+  HP     M F+
Sbjct: 253 GYKHSYFDKTLEHMIGKRFLLVAYKLSFLHPKSQKPMEFE 292


>UniRef50_Q1WS43 Pseudouridine synthase n=3 Tax=Lactobacillus RepID=Q1WS43_LACS1
          Length = 296

 Score =  249 bits (638), Expect = 5e-65,   Method: Composition-based stats.
 Identities = 70/215 (32%), Positives = 103/215 (47%), Gaps = 13/215 (6%)

Query: 13  WLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ-------AESVHRLDM 65
            L I+Y+D + +VV+KP  L SVPG      D+++ R++    Q          + RLD 
Sbjct: 76  PLDIIYEDSNWLVVDKPPLLSSVPGPSNRT-DTLVNRVKFHLWQQKSKDLVPHVITRLDR 134

Query: 66  ATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQ 125
            TSG+++VA  + A+  + +Q  E    K+Y+A V G  +   G++D PL        + 
Sbjct: 135 DTSGLVLVAKHRFAQGLINKQVEEHSIDKKYLAVVEGIITEKHGIIDKPLGPRENGIGQM 194

Query: 126 KVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPE 185
               +TGK A+TEY V EY  D    V  K  TGR+HQ+R H  ++ H ++GD  Y    
Sbjct: 195 --VTDTGKIAKTEYWVREYLGDKATLVECKLHTGRTHQIRAHFSSINHALVGDELYGGR- 251

Query: 186 ARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PAD 218
                 R  LHA  L    P       FK+  P D
Sbjct: 252 LDWGLERQALHAYQLAYVDPFTQEEKLFKSEMPKD 286


>UniRef50_C8NZX3 Pseudouridine synthase n=1 Tax=Erysipelothrix rhusiopathiae ATCC
           19414 RepID=C8NZX3_ERYRH
          Length = 298

 Score =  249 bits (637), Expect = 5e-65,   Method: Composition-based stats.
 Identities = 67/218 (30%), Positives = 104/218 (47%), Gaps = 10/218 (4%)

Query: 8   PPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR-------DYPQAESV 60
            P +  + ++Y+D++++VVNKP GL+  PG   +  D+++  +          Y +   V
Sbjct: 71  EPVKMDIDVVYEDEYLLVVNKPRGLVVHPGNGVKS-DTLLHGLLYYLNSNCDHYIRPGLV 129

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HR+D  TSG++V+A      + L  Q  ++   + Y A V G    A  L+D P+  D  
Sbjct: 130 HRIDRNTSGLLVIAKDDKTHQFLAEQLLDKTMNRTYYALVHGVLPQAHVLIDAPIGPDKS 189

Query: 121 NRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRF 180
           N     V     KPA+T +E +E    N++ +  K  TGR+HQ+RVH L    P+ GD  
Sbjct: 190 NTKIMTVNQARSKPARTHFEKIETYI-NSSLICCKLETGRTHQIRVHALHANIPLHGDPQ 248

Query: 181 YASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           Y  P +        L A  L   HP Y   M F+ P  
Sbjct: 249 YGHP-SDTDKTGQYLCAARLEFVHPKYLKLMQFEIPLP 285


>UniRef50_Q12RE8 Pseudouridine synthase n=83 Tax=Bacteria RepID=Q12RE8_SHEDO
          Length = 593

 Score =  249 bits (637), Expect = 5e-65,   Method: Composition-based stats.
 Identities = 96/223 (43%), Positives = 135/223 (60%), Gaps = 18/223 (8%)

Query: 7   NPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAE---SVHRL 63
           NP  +  + ++YQD+H++V++KP+  LSVPG+     DSV TRI RD+P A     VHRL
Sbjct: 379 NPADDKQITVIYQDEHLLVISKPAEFLSVPGK--NISDSVHTRIIRDFPSASGPIIVHRL 436

Query: 64  DMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSP----AEGLVDLPLICDW 119
           DM+TSG++V+AL K A   L++QF  R   K+Y+A + G         EG++ LPL  D 
Sbjct: 437 DMSTSGLMVIALNKEAHESLQKQFILRTVTKRYIALLDGLLPNRTAGDEGIISLPLRGDL 496

Query: 120 PNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLA---LGHPIL 176
            +RP+Q VC+E GK A+T +++++     T +V L P TGR+HQLRVH      L  PI+
Sbjct: 497 DDRPRQLVCHEHGKSAETRWQIIDIQQGRT-KVFLYPKTGRTHQLRVHCAHSQGLHLPIV 555

Query: 177 GDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
           GD  Y        A RL LHAE L+ THP    ++ F+  ADF
Sbjct: 556 GDDHYG-----VRASRLHLHAESLSFTHPQSREALHFQLDADF 593


>UniRef50_D2M2K8 Pseudouridine synthase, RluA family n=1 Tax=Bacillus
           cellulosilyticus DSM 2522 RepID=D2M2K8_BACS4
          Length = 298

 Score =  249 bits (636), Expect = 7e-65,   Method: Composition-based stats.
 Identities = 71/216 (32%), Positives = 108/216 (50%), Gaps = 11/216 (5%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES------VHR 62
           P +  L I+++D+H++++NKP  L ++P R  E + S+   I   Y +         V R
Sbjct: 78  PYKIKLHIIFEDEHVIIINKPPHLPTIPTR-NEGEPSLAGAILAYYIENGIPSTFHAVSR 136

Query: 63  LDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNR 122
           LD  TSG+++VA  +       +  +  E K+ YVA V G  S     +DLP+     + 
Sbjct: 137 LDRDTSGLVMVAKHRYMHDLCVKLQKSYEIKRSYVALVEGILSDDYNTIDLPISRKTTSI 196

Query: 123 PKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYA 182
            +++V  E GK A T YEV++  +     + L   TGR+HQ+RVHM A+GHP+LGD  Y 
Sbjct: 197 IEREV-NEFGKSAITHYEVLKRYS-GATLLQLTLETGRTHQIRVHMSAIGHPLLGDTLYG 254

Query: 183 SPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
                    R  LH+  L+  HP      TF  P  
Sbjct: 255 GD--VRYIDRQALHSHQLSFFHPINKREYTFHCPIP 288


>UniRef50_A5IZB6 Pseudouridine synthase n=4 Tax=Mycoplasma RepID=A5IZB6_MYCAP
          Length = 305

 Score =  248 bits (635), Expect = 9e-65,   Method: Composition-based stats.
 Identities = 57/231 (24%), Positives = 104/231 (45%), Gaps = 20/231 (8%)

Query: 4   ENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP-------- 55
           E+     +  L I Y+D++++++NKPSGL+  P       D+++  +   +         
Sbjct: 66  ESNIEAVDMPLDIRYEDEYLLILNKPSGLVVHPAPGH-LNDTLVNALMYHFKNNLSDANG 124

Query: 56  --QAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDL 113
             +   VHR+D  TSG++++A       EL +  +  + K+ Y+A   G        ++L
Sbjct: 125 LLRLGIVHRIDKDTSGLLIIAKDNETHNELAKMLKNHQIKRTYLAICEGILPNKTTKINL 184

Query: 114 PLICDWPNRPKQKVCYETGKPAQTEYEVVEYAA---DNTARVVLKPITGRSHQLRVHMLA 170
           P+  D  NR    + ++ GK + T   +++         + V  +  TGR+HQ+RVH+  
Sbjct: 185 PIQRDTKNRKLMSI-HKDGKSSVTYVHMLKSFYIDNKPYSLVKCELETGRTHQIRVHLAY 243

Query: 171 LGHPILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
           + HP+ GD  Y             LHA  L+  HP     +   +  P +F
Sbjct: 244 IKHPVYGDSIYGKSVDEFN---QRLHAYKLSFMHPVINKLIEVYSDIPKEF 291


>UniRef50_C5WJF2 Pseudouridine synthase n=104 Tax=Lactobacillales RepID=C5WJF2_STRDG
          Length = 341

 Score =  248 bits (635), Expect = 9e-65,   Method: Composition-based stats.
 Identities = 68/202 (33%), Positives = 105/202 (51%), Gaps = 5/202 (2%)

Query: 15  VILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ-AESVHRLDMATSGVIVV 73
             LY+DDH+++VNKP G+ +     E  + +++  +     +    VHRLDM TSGVIV 
Sbjct: 128 DCLYEDDHLIIVNKPEGMKTHGN--EPTELALLNHVSAYTGRTCYVVHRLDMETSGVIVF 185

Query: 74  ALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYETGK 133
           A T      L R   +RE  + Y A V G  S  E     P+     +R K+ V  + G+
Sbjct: 186 AKTPFILPILNRLLEKREISRDYWALVHGTLSSKEVSYREPIGRHRHDRRKRVVDVKQGQ 245

Query: 134 PAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARAMAPRL 193
            A T+ ++++    N + +  +  TGR+HQ+RVH+   GH +LGD  Y+  +A    PRL
Sbjct: 246 KAVTDVKLLKSFKQNVSLINCRLQTGRTHQIRVHLSHHGHALLGDPLYSKGKAE--CPRL 303

Query: 194 LLHAEMLTITHPAYGNSMTFKA 215
           +LHA  L + HP     +  +A
Sbjct: 304 MLHAHQLRLRHPLTQEMICVQA 325


>UniRef50_A0Y082 Pseudouridine synthase n=2 Tax=Alteromonadales RepID=A0Y082_9GAMM
          Length = 235

 Score =  248 bits (635), Expect = 9e-65,   Method: Composition-based stats.
 Identities = 88/226 (38%), Positives = 130/226 (57%), Gaps = 9/226 (3%)

Query: 3   MENYNPPQEPW-LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRD-------Y 54
           ++N+  P+      ILYQD+ I+V+NKPSGLLS+ G+  E+ DSV  R+          +
Sbjct: 10  VDNFIAPKCIDTFSILYQDNDILVINKPSGLLSLSGKNSENWDSVHYRLVNGQKGLTPAF 69

Query: 55  PQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLP 114
            +A+ VHRLD+ TSG+++V+L   + + L +QF+ R  KK YVA + G  S   G +D P
Sbjct: 70  LKAKLVHRLDLGTSGIMLVSLNDVSSKHLNKQFQLRSVKKHYVAVLQGCISEDRGQIDAP 129

Query: 115 LICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNT-ARVVLKPITGRSHQLRVHMLALGH 173
           +  D    P+ K+C   GKPA TE+ V++  A+     V   P+TGR+HQLR+H   +GH
Sbjct: 130 IAKDTQLFPRVKICKLEGKPAVTEFNVIKRLANPVRTYVHFSPLTGRTHQLRIHSHFIGH 189

Query: 174 PILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
           PILG   Y S  +  ++ RL LHA  L   HP    ++    P+ F
Sbjct: 190 PILGCDLYKSAHSEKLSKRLQLHASDLFFEHPTTNQAIHIHCPSPF 235


>UniRef50_Q83G23 Pseudouridine synthase n=2 Tax=Tropheryma whipplei
           RepID=Q83G23_TROWT
          Length = 303

 Score =  248 bits (634), Expect = 1e-64,   Method: Composition-based stats.
 Identities = 69/210 (32%), Positives = 111/210 (52%), Gaps = 10/210 (4%)

Query: 14  LVILYQDDHIMVVNKPSGLLSV--PGRLEEHKDSVMTRIQRDYP---QAESVHRLDMATS 68
           L ++Y DD + V++KP+G+ +   PG         ++ +        +   VHRLD  TS
Sbjct: 76  LRVIYSDDDLFVIDKPAGVAAHASPGWCGPTVTGCLSGLLAACGPQDRQGIVHRLDANTS 135

Query: 69  GVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVC 128
           G++V+A +  A   LK  FR+R   K+Y A V G+P P+ G+++ P+  D  +R +  + 
Sbjct: 136 GLMVLAKSDLAYHNLKAAFRDRAIHKRYKALVQGYPDPSSGVINAPIGRDLKHRDRFCID 195

Query: 129 YETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASP---E 185
           Y +G+ A T+Y   E        + + P TGR+HQ+RVH  AL HP++GD  Y +     
Sbjct: 196 Y-SGRDAVTQYSTEEVYP-GFTLLSVAPKTGRTHQIRVHFSALRHPLVGDVKYGADPVFS 253

Query: 186 ARAMAPRLLLHAEMLTITHPAYGNSMTFKA 215
            +    R  LHA  L+ THP  G  + F++
Sbjct: 254 QKVNLKRQWLHAYHLSFTHPVSGVFVEFES 283


>UniRef50_C7GZW0 Pseudouridine synthase n=1 Tax=Eubacterium saphenum ATCC 49989
           RepID=C7GZW0_9FIRM
          Length = 318

 Score =  248 bits (634), Expect = 1e-64,   Method: Composition-based stats.
 Identities = 69/225 (30%), Positives = 117/225 (52%), Gaps = 14/225 (6%)

Query: 3   MENYNPPQE-PWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQ-----RDYPQ 56
             +Y  P     +  +Y+D+H++V++KP+G++  P    E        I       +  +
Sbjct: 84  ESSYFTPYSGIEINAVYEDEHLLVIDKPAGIVVHPTHGYEENTIAHALIHYMDTVGEEFK 143

Query: 57  AESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLI 116
              ++RLDM T+G++++A  +  +  +  + +    +K+Y+A V G P   EG++D P+ 
Sbjct: 144 IRFINRLDMDTTGLLMIAKNQFIQNAVVSEMKRGNVEKRYLAVVHGLPCNREGIIDAPIK 203

Query: 117 CDWPNRPKQKVCYETGKPAQTEYEVVEYAAD-NTARVVLKPITGRSHQLRVHMLALGHPI 175
                  +Q    E GKP+ TEY+VV  + + N + + ++  TGR+HQ+RVH+  +G PI
Sbjct: 204 AVEGEPRRQ--VMEGGKPSITEYKVVGVSDELNVSFLDVRLHTGRTHQIRVHLKHIGCPI 261

Query: 176 LGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PAD 218
           LGD FY   E+   A R LLH+  L  THP     +   A  P D
Sbjct: 262 LGDEFYGGKES---ADRQLLHSRYLRFTHPVSKKIVELTANLPDD 303


>UniRef50_C2L1H2 Pseudouridine synthase n=1 Tax=Oribacterium sinus F0268
           RepID=C2L1H2_9FIRM
          Length = 335

 Score =  247 bits (633), Expect = 1e-64,   Method: Composition-based stats.
 Identities = 65/253 (25%), Positives = 111/253 (43%), Gaps = 35/253 (13%)

Query: 1   MGMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQA--- 57
           M  EN  PP +  L I+Y+D  I++++KP+ L   P      K      +      +   
Sbjct: 77  MEEENSAPPYDFPLDIVYEDRDILLLDKPARLPCHPSPGHFEKTLAGAIVFYQMQNSSAS 136

Query: 58  ----ESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLV-- 111
                 +HRLD+ TSG+I++A  + A   L +  +E   ++ Y+A   G+P  + G +  
Sbjct: 137 SFVCHFIHRLDLDTSGLILLAKNRLAASVLNKDMKEGRIQRSYLAFCQGNPEFSLGEIQG 196

Query: 112 ------------------DLPLICDWPNRPKQKVCYETGKPAQTEYEVVEYAAD-NTARV 152
                               P+      +  + V ++ G+ A + + V+ Y  + N + +
Sbjct: 197 FTRLEEKKKKEFNYAFAISAPIARVEEEKMLRTVNFQKGQEALSYFNVLNYFPEKNYSLL 256

Query: 153 VLKPITGRSHQLRVHMLALGHPILGDRFYASPEA-----RAMAPRLLLHAEMLTITHPAY 207
            L+  TGR+HQ+RVH+  L  P+LGD  Y + E           R  LH+  ++ THP  
Sbjct: 257 QLQLATGRTHQIRVHLSYLSCPLLGDSLYGNGEESVFSQNIGLSRQALHSYSISFTHPIR 316

Query: 208 GNSMTF--KAPAD 218
              M F  + P D
Sbjct: 317 KEKMFFQRELPPD 329


>UniRef50_A8RHQ2 Pseudouridine synthase n=2 Tax=Clostridium RepID=A8RHQ2_9CLOT
          Length = 287

 Score =  247 bits (633), Expect = 1e-64,   Method: Composition-based stats.
 Identities = 68/220 (30%), Positives = 113/220 (51%), Gaps = 13/220 (5%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQA------ESVHR 62
           P +  L I+Y+D+ I+V+NK +G+   P +   + +++   +   + +         ++R
Sbjct: 64  PVKLPLSIVYEDEDILVINKDAGVPIHPSQGH-YDNTLANAVSWYFHEKGEAFTYRVINR 122

Query: 63  LDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNR 122
           LD  T+G++V+A    +   L  Q   R  +++Y A V GH +P EG VD P+     + 
Sbjct: 123 LDRDTTGLLVLARHMLSACILSEQMTGRRIRREYRAIVLGH-TPEEGTVDSPIARAEGST 181

Query: 123 PKQKVCYETGKPAQTEYEVVEYAADN-TARVVLKPITGRSHQLRVHMLALGHPILGDRFY 181
            +++V +ETG+ A T +  + Y  +   + V L   TGR+HQ+RVHM ++GHP+ GD  Y
Sbjct: 182 IERRVDHETGERAVTHFRTLLYNEEKDLSLVSLSLETGRTHQIRVHMRSIGHPLPGDFLY 241

Query: 182 ASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
                     R  LH+ +L   HP  G  M F A  P D 
Sbjct: 242 CPD--YRYIDRQPLHSYLLRFEHPITGKEMEFTAGLPEDM 279


>UniRef50_D0P480 Ribosomal large subunit pseudouridine synthase A, putative n=1
           Tax=Phytophthora infestans T30-4 RepID=D0P480_PHYIN
          Length = 363

 Score =  247 bits (633), Expect = 2e-64,   Method: Composition-based stats.
 Identities = 90/223 (40%), Positives = 120/223 (53%), Gaps = 17/223 (7%)

Query: 13  WLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDMATSGVIV 72
            L IL++DD ++VVNKP+ +LSV G   +   SV   + R YP A  VHRLD  TSG++V
Sbjct: 116 PLKILFRDDAVIVVNKPANILSVDGTDPDALMSVHRCVARVYPNARMVHRLDQETSGLLV 175

Query: 73  VALTKAAERELKRQFREREPKKQYVARVWGHP-------SPAEGLVDLPLICDWPNRPKQ 125
           VALTK+A + L  QFR+R   K YVARV G         S +   V +P+         Q
Sbjct: 176 VALTKSAAQSLNAQFRDRSVDKTYVARVDGWMMNDLEEKSESPRRVQIPMEKHLTKSLIQ 235

Query: 126 KVCYE------TGKPAQTEYEVVEYAADN----TARVVLKPITGRSHQLRVHMLALGHPI 175
            V  +      +   + TEY V+          +  V LKP+TG++HQLR+HM  LGHPI
Sbjct: 236 HVVSDREVDPSSSLWSTTEYSVLSRDESGDDRKSTLVELKPVTGKTHQLRLHMQHLGHPI 295

Query: 176 LGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           LGD  Y+       A RL LHA  L+ THP     +TF++P  
Sbjct: 296 LGDSLYSPDVVYHRASRLCLHAAKLSFTHPVTNERLTFESPCP 338


>UniRef50_D2RBY1 Pseudouridine synthase, RluA family n=1 Tax=Gardnerella vaginalis
           409-05 RepID=D2RBY1_GARVA
          Length = 321

 Score =  247 bits (632), Expect = 2e-64,   Method: Composition-based stats.
 Identities = 69/230 (30%), Positives = 109/230 (47%), Gaps = 16/230 (6%)

Query: 3   MENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKD--SVMTRI-------QRD 53
            E  N      + I+Y DD ++V++KP G+ S   +          +  +         D
Sbjct: 81  EEQNNESSVCNIPIIYNDDDVVVIDKPVGVASHAAKGWSGPTVPECLEAVGIDIKTTLCD 140

Query: 54  YPQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDL 113
             +   V RLD+ TSG+++V  T  A   +K QF +   KK Y A V G  +  +  +D 
Sbjct: 141 ESRKGIVSRLDVGTSGLMLVCKTDFAYEVMKNQFAKHIVKKTYHALVQGDLAQDKATIDA 200

Query: 114 PLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGH 173
           P+     +  +  +    GKPA T ++V+E  +     V +   TGR+HQ+RVH  ++GH
Sbjct: 201 PIGRAKVSDFRFTI-TSDGKPAVTHWDVLERFSQ-ATLVSVNLETGRTHQIRVHFSSIGH 258

Query: 174 PILGDRFYASPE---ARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PAD 218
           P++GD  Y +      +    R  LH+  LT THP  G S+T K+  P D
Sbjct: 259 PLVGDSMYGANPVLAQKLGLQRQWLHSMELTFTHPRTGKSVTVKSHYPLD 308


>UniRef50_A6TSZ4 Pseudouridine synthase n=1 Tax=Alkaliphilus metalliredigens QYMF
           RepID=A6TSZ4_ALKMQ
          Length = 308

 Score =  247 bits (631), Expect = 3e-64,   Method: Composition-based stats.
 Identities = 69/219 (31%), Positives = 112/219 (51%), Gaps = 12/219 (5%)

Query: 8   PPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES------VH 61
            PQE    ++Y+D  ++V+NK  G++S P +    KD++    Q    +         V+
Sbjct: 80  EPQEIPFNVVYEDIDVIVINKEPGIVSHPTKSHP-KDTIANAAQNYLEKKGVACRIRFVN 138

Query: 62  RLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPN 121
           RLDM TSG++V+A        + +Q +  E  K+YVA V G     EG +D  +     +
Sbjct: 139 RLDMDTSGLLVIAKNPYTHHIMSQQMKANEITKKYVAFVKGVVVANEGEIDGAIYRS-SD 197

Query: 122 RPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFY 181
              ++V  + G+ + T++ V+E  AD T    +  +TGR+HQ+RVHM ++GHP+LGD  Y
Sbjct: 198 ETIKRVVDDRGQQSLTKFTVLERYADATML-EVSLLTGRTHQIRVHMESIGHPMLGDHLY 256

Query: 182 ASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PAD 218
              +   +  R  LHA  L+   P Y   +  +A  P D
Sbjct: 257 GYVDTE-LIRRQALHASYLSFLQPRYKEKIEVRASLPKD 294


>UniRef50_A5ZUU7 Pseudouridine synthase n=1 Tax=Ruminococcus obeum ATCC 29174
           RepID=A5ZUU7_9FIRM
          Length = 293

 Score =  246 bits (629), Expect = 4e-64,   Method: Composition-based stats.
 Identities = 61/216 (28%), Positives = 103/216 (47%), Gaps = 11/216 (5%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES------VHR 62
           P    + +LY+D+ I+VVNKP+ +   P  L  + +++   +               ++R
Sbjct: 76  PTPLNIPVLYEDEDILVVNKPADMPVHPS-LGNYTNTLANGVAAYLETKGESCPFRCINR 134

Query: 63  LDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNR 122
           LD  TSG +++A    +   L  Q R R+  + Y+A V G P    G +  P+     + 
Sbjct: 135 LDRDTSGALILAKNALSAAILSVQMRNRQISRTYLAVVEGIPRQ-SGTISAPISRAADSV 193

Query: 123 PKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYA 182
            ++++ +E G+ A T Y+++E   +N + + +   TGR+HQ+RVHM  +GHP+  D  Y 
Sbjct: 194 IERRIDFENGESAITHYQLLE-VKNNHSLLEIHLETGRTHQIRVHMGYIGHPLPADYLYN 252

Query: 183 SPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
                    R  LH+  L   HP  G  M   AP  
Sbjct: 253 P--VYDTFKRQPLHSLQLKFCHPITGTPMCLMAPVP 286


>UniRef50_B9DS29 Pseudouridine synthase n=85 Tax=Firmicutes RepID=B9DS29_STRU0
          Length = 301

 Score =  246 bits (629), Expect = 4e-64,   Method: Composition-based stats.
 Identities = 69/206 (33%), Positives = 101/206 (49%), Gaps = 12/206 (5%)

Query: 13  WLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDY-------PQAESVHRLDM 65
            L I+Y+DDH +V+NKP G  S+P  +  H +++   I+  Y        Q   V RLD 
Sbjct: 75  PLDIVYEDDHFLVLNKPVGYASIPSAI--HSNTIANFIKAYYFEQNYPNKQVHIVTRLDR 132

Query: 66  ATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPS-PAEGLVDLPLICDWPNRPK 124
            TSG+++ A    A   L +Q ++R  +K+Y A V G+   P  G +  P+     +   
Sbjct: 133 DTSGLMLFAKHGYAHARLDKQLQKRSIEKRYFALVSGNGQLPDFGEIVEPIGRS-KDSII 191

Query: 125 QKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASP 184
            +     GK A+T YEVV   A+N   V +K  TGR+HQ+RVH   +G P+LGD  Y   
Sbjct: 192 TRTVDPMGKYAKTTYEVVARFAENVHLVDIKLHTGRTHQIRVHFSHIGFPLLGDDLYGGR 251

Query: 185 EARAMAPRLLLHAEMLTITHPAYGNS 210
                  R  LH   L+  +P   N 
Sbjct: 252 MDLG-IERQALHCHFLSFFNPFTENE 276


>UniRef50_Q5QZ45 Pseudouridine synthase n=2 Tax=Gammaproteobacteria
           RepID=Q5QZ45_IDILO
          Length = 315

 Score =  245 bits (628), Expect = 6e-64,   Method: Composition-based stats.
 Identities = 73/212 (34%), Positives = 108/212 (50%), Gaps = 12/212 (5%)

Query: 16  ILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ---AESVHRLDMATSGVIV 72
           ILY+DD +M++NKPSG+    G   +    ++  ++   P+    E VHR+D  TSG+++
Sbjct: 94  ILYEDDALMLINKPSGVAVHGGSGLQFG--LIEGLRALRPKEKSLELVHRIDRDTSGLLL 151

Query: 73  VALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKV-CYET 131
           VA  ++  R L  Q R +E  KQY+A V G        V+ PL  +     ++ V     
Sbjct: 152 VAKKRSVLRSLHEQLRNKEMNKQYLALVRGQWQKRVRSVEAPLKKNTLKSGERIVRVDAE 211

Query: 132 GKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPE-----A 186
           GK + T + + +   + T  V   P+TGR+HQ+RVH L  GHPI  D  Y   +     +
Sbjct: 212 GKASLTRFRIQQRYKEGT-LVEASPVTGRTHQIRVHALHAGHPIAKDPKYGDTDFDNTMS 270

Query: 187 RAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           R    RL LHA  L   HP  G  + F+AP D
Sbjct: 271 RLGLNRLFLHAWQLRFLHPVTGKEVAFEAPLD 302


>UniRef50_B1XXM0 Pseudouridine synthase n=6 Tax=Burkholderiales RepID=B1XXM0_LEPCP
          Length = 369

 Score =  245 bits (628), Expect = 6e-64,   Method: Composition-based stats.
 Identities = 66/226 (29%), Positives = 107/226 (47%), Gaps = 23/226 (10%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVM-----TRIQRDYPQAESVHRLD 64
           +   L ++++D H++V++KP+GL+  P         +             P+A  VHRLD
Sbjct: 115 EAMTLAVVHEDAHLLVIDKPAGLVVHPAAGHWSGTLLNGLLAHHAAAAHLPRAGIVHRLD 174

Query: 65  MATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPK 124
             TSG+++VA +  A   L R    R+ K++Y+A V G       ++D PL  D  +R +
Sbjct: 175 KDTSGLMLVAKSLQAHTALVRAIAARDVKREYLALVHGAVMDGLQVIDAPLGRDPVSRVR 234

Query: 125 QKVCYETGKPAQTEYEVVE----------------YAADNTARVVLKPITGRSHQLRVHM 168
             +   +GKPA+T+   +                  A    + V  +  TGR+HQ+RVH+
Sbjct: 235 MAIV-ASGKPARTDVRRLAVAELPGDGVRQLPGATRAPRQVSAVHCQLHTGRTHQIRVHL 293

Query: 169 LALGHPILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFK 214
            + GHP+L D  Y    A  +  R  LHA  L + HP  G  + F+
Sbjct: 294 ASRGHPLLADAMYGGAPAFGL-QRQALHAARLHLLHPIDGRPLAFE 338


>UniRef50_A4J1I1 Pseudouridine synthase n=1 Tax=Desulfotomaculum reducens MI-1
           RepID=A4J1I1_DESRM
          Length = 303

 Score =  245 bits (628), Expect = 6e-64,   Method: Composition-based stats.
 Identities = 72/220 (32%), Positives = 116/220 (52%), Gaps = 11/220 (5%)

Query: 4   ENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDY------PQA 57
             Y PP+   L I+ +D+ I +VNK  G+   P  L     ++   +   +      P  
Sbjct: 73  NQYLPPEPLDLSIISEDEDIALVNKQPGMCVHPT-LAYPSGTLANGLVYHWLENNPAPTF 131

Query: 58  ESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLIC 117
            +V+R+D  TSG+++VA    + ++L  Q + ++  + YVA V G      G +DLPL  
Sbjct: 132 HAVNRIDRNTSGLVLVAKNSYSAQKLFLQRKRKQLARSYVALVHGKIVQRNGYIDLPLEK 191

Query: 118 DWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILG 177
                 K+++   TG+ A T +EV++Y  D T  + L P TGR+HQ+RVH+  LGHP++G
Sbjct: 192 CEGKTTKRQI-SSTGQQALTRFEVLQYITDCT-LIRLMPETGRTHQIRVHLSHLGHPLVG 249

Query: 178 DRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPA 217
           D  Y    A+    R  LHA+ ++  HP  G+ M+F+ P 
Sbjct: 250 DTLYGGSIAQ--IGRHCLHADKISFLHPRTGHPMSFQIPL 287


>UniRef50_Q9KQH0 Ribosomal large subunit pseudouridine synthase C n=59
           Tax=Proteobacteria RepID=RLUC_VIBCH
          Length = 315

 Score =  245 bits (627), Expect = 8e-64,   Method: Composition-based stats.
 Identities = 73/209 (34%), Positives = 108/209 (51%), Gaps = 9/209 (4%)

Query: 16  ILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ-AESVHRLDMATSGVIVVA 74
           I+Y+DDH++++NKPSG     G           R  R   +  E VHR+D  TSG+++VA
Sbjct: 97  IVYEDDHLLILNKPSGTAVHGGSGLHFGAIEALRALRPQARFLELVHRIDRDTSGILLVA 156

Query: 75  LTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYETGKP 134
             ++A R L+ QFRE+  +K Y A V GH      +V+ PL+ +  N   +      GKP
Sbjct: 157 KKRSALRHLQAQFREKTVQKYYYALVMGHWDAECKVVNAPLLKNEVNSIVR--VNPNGKP 214

Query: 135 AQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPE-----ARAM 189
           ++T + ++E  A+    V   P+TGR+HQ+RVH   +GHPI  D  Y         A+  
Sbjct: 215 SETRFRILEKFAE-ATLVQASPVTGRTHQIRVHTQYMGHPIAWDDRYGDRRFDAYTAQFG 273

Query: 190 APRLLLHAEMLTITHPAYGNSMTFKAPAD 218
             RL LHA  +   HPA    +   AP +
Sbjct: 274 IERLFLHAANIQFVHPASEKKLEIHAPLE 302


>UniRef50_C0EHV8 Putative uncharacterized protein n=1 Tax=Clostridium methylpentosum
           DSM 5476 RepID=C0EHV8_9CLOT
          Length = 299

 Score =  245 bits (626), Expect = 9e-64,   Method: Composition-based stats.
 Identities = 68/216 (31%), Positives = 102/216 (47%), Gaps = 10/216 (4%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAE------SVHR 62
           P      I Y+DD +++VNKP+G    P     ++DS+       Y Q         V+R
Sbjct: 75  PVPGPFDIAYEDDDLLLVNKPAGTPVHPSPGH-YEDSLANYSAWQYAQRREQLVFRPVNR 133

Query: 63  LDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNR 122
           LD  TSG++ VA    A+  L +Q      ++ Y A V G PSPA G +DLP+     + 
Sbjct: 134 LDRGTSGLLCVAKNAHAQARLSQQLHTGAFERIYYAVVCGAPSPAAGTIDLPIGRTPGSV 193

Query: 123 PKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYA 182
            K++V  +  + A T YE V         + ++  TGR+HQ+RVH   LG P+ GD  Y 
Sbjct: 194 LKRRVDPQGAR-AVTHYETVRVNGA-YTLLKIRLETGRTHQIRVHFAHLGCPLFGDFLYG 251

Query: 183 SPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           + E R +     LH+  + + HP  G  +    P  
Sbjct: 252 T-ERRDVVEGHALHSGEIRLLHPISGEEIRCSVPLP 286


>UniRef50_P70870 Ribosomal large subunit pseudouridine synthase D n=23 Tax=Borrelia
           RepID=RLUD_BORBU
          Length = 326

 Score =  244 bits (625), Expect = 1e-63,   Method: Composition-based stats.
 Identities = 71/210 (33%), Positives = 108/210 (51%), Gaps = 13/210 (6%)

Query: 5   NYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP--------- 55
           +   P    + I+Y+D +++V+NKP G+LS PG +    D+V+  +              
Sbjct: 75  DCLRPSNIPIAIIYEDSNVIVLNKPQGILSHPG-ISHWDDTVVNFLLYHIKSLKINFNEE 133

Query: 56  --QAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDL 113
             +   VHRLD  TSGV++ A   +  R L +QF+++   K Y+A V G+ +   G ++ 
Sbjct: 134 KIRPGIVHRLDKDTSGVLICAKNISTLRFLAQQFKDKRTNKVYIAIVKGNFNSFFGSIES 193

Query: 114 PLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGH 173
            +  D  NR K  V  + GK A TEY ++    +  + + LKP TGR+HQLRVHM  L  
Sbjct: 194 FIDRDKHNRKKFSVSKDRGKKALTEYRLLLNFGE-YSLLALKPKTGRTHQLRVHMKYLNF 252

Query: 174 PILGDRFYASPEARAMAPRLLLHAEMLTIT 203
           PILGD  Y   +       L+LH+  L I 
Sbjct: 253 PILGDEVYGRVDGSLKKITLMLHSYKLEID 282


>UniRef50_C9KIU1 Pseudouridine synthase n=3 Tax=Veillonellaceae RepID=C9KIU1_9FIRM
          Length = 296

 Score =  244 bits (625), Expect = 1e-63,   Method: Composition-based stats.
 Identities = 71/217 (32%), Positives = 110/217 (50%), Gaps = 10/217 (4%)

Query: 8   PPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRI-----QRDYPQAESVHR 62
            P++  L I Y+DD++++VNKP+G L  P   E H       +       ++     VHR
Sbjct: 72  EPEDLPLDIRYEDDYLLIVNKPAGQLVHPTTKEAHGTLGNAVLYWYKAHGEHHAYHPVHR 131

Query: 63  LDMATSGVIVVALTKAAERELK-RQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPN 121
           LD  TSG++++A     + +L  R    +   ++Y+A + G  +P EGL+D P+    P+
Sbjct: 132 LDRNTSGLVLIAKVPQVQYKLTPRHGEGKLFHREYLALIEGELTPPEGLIDAPIARALPS 191

Query: 122 RPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFY 181
              +KV    G+ A+T Y+ V+      + + L   TGR+HQ+RVH+  LGHP+LGD  Y
Sbjct: 192 IILRKV-SPDGQTARTHYDTVQTDG-KLSLIHLVLDTGRTHQIRVHLAHLGHPLLGDDLY 249

Query: 182 ASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
               AR    R  LHA  L   HP  G  +  + P  
Sbjct: 250 GGNLAR--IKRQALHAARLHFRHPMTGAEIDVQVPLP 284


>UniRef50_B5YAZ5 Pseudouridine synthase n=2 Tax=Dictyoglomus RepID=B5YAZ5_DICT6
          Length = 226

 Score =  244 bits (625), Expect = 1e-63,   Method: Composition-based stats.
 Identities = 73/215 (33%), Positives = 108/215 (50%), Gaps = 13/215 (6%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVM---TRIQRDYPQAE-----SVHRLDM 65
           L ++Y+D+H++VVNKP+G+L   G + +    +      I+  Y +        VHRLD 
Sbjct: 7   LEVIYEDNHLLVVNKPAGILVQ-GDITKSTTLLEISKAYIKEKYKKPGNVFLAIVHRLDK 65

Query: 66  ATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQ 125
             SGV++ A    +   L   FRER+ +K+Y+A   G     +G +   L+     R  +
Sbjct: 66  PVSGVVIFARNSKSAGRLSEAFRERKVEKEYIALCKGIFKVKKGTISESLLWVEKERKAR 125

Query: 126 KVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPE 185
               +  K A T YEV+E    N + V L P TGR HQLR H+  +GHPILGD  Y    
Sbjct: 126 VSQDDKSKNAITHYEVLEEFK-NLSLVRLIPETGRKHQLRAHLSYIGHPILGDEKYGGG- 183

Query: 186 ARAMAPRLLLHAEMLTITHPAYGNSMTFKAP-ADF 219
            R    R+ LH + + + HP   + M F+A   DF
Sbjct: 184 -RIFKDRIFLHCKKMAVPHPVRKDIMEFEAKIPDF 217


>UniRef50_C8Q1E7 Pseudouridine synthase n=1 Tax=Enhydrobacter aerosaccus SK60
           RepID=C8Q1E7_9GAMM
          Length = 243

 Score =  244 bits (625), Expect = 1e-63,   Method: Composition-based stats.
 Identities = 92/210 (43%), Positives = 128/210 (60%), Gaps = 10/210 (4%)

Query: 17  LYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDMATSGVIVVALT 76
           LY+DD I V++KP GLLSV G+  E K S+ +R+ +  P  + +HRLDM TSG+I+ A  
Sbjct: 37  LYRDDDIWVIDKPHGLLSVDGK--ELKVSLQSRLLKADPNVKLIHRLDMDTSGIIIFARH 94

Query: 77  KAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYETGKPAQ 136
             A+  + +QF +R P K+Y A VWG P P +G +D+P+  D P +PK  V     K A 
Sbjct: 95  SEAQTHISKQFIDRIPSKEYQALVWGTP-PQQGEIDVPVRYDPPQKPKHIVDMSWDKRAY 153

Query: 137 TEYEVVE---YAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYA----SPEARAM 189
           T+YE +          +RV L P+TGRSHQLRVHML +GH +LGD  YA    + +A  +
Sbjct: 154 TKYETLHHELREGKAVSRVALYPVTGRSHQLRVHMLHIGHVMLGDPIYAQDVLNGQAFDL 213

Query: 190 APRLLLHAEMLTITHPAYGNSMTFKAPADF 219
           +PRL LHA  L + HP  G  M +++P  F
Sbjct: 214 SPRLCLHARKLRLKHPNTGVWMEWESPVPF 243


>UniRef50_Q38W13 Pseudouridine synthase n=4 Tax=Lactobacillus RepID=Q38W13_LACSS
          Length = 300

 Score =  244 bits (624), Expect = 2e-63,   Method: Composition-based stats.
 Identities = 66/213 (30%), Positives = 109/213 (51%), Gaps = 12/213 (5%)

Query: 13  WLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ-------AESVHRLDM 65
            + +LY+DD+ +VVNKP+GL ++PG      D+++ RI+  + Q          + RLD 
Sbjct: 78  PIKVLYEDDYWLVVNKPAGLATIPGPTNTT-DTLLNRIKGYWQQNGATDLVPHIITRLDF 136

Query: 66  ATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQ 125
            TSG+++ A  + A+  L+ Q  + + +K Y+A V G   P  G +  P+       P++
Sbjct: 137 DTSGIVLAAKHQVAQSLLQPQIEQHQLQKFYLAVVAGTGLPEFGTIKAPIGR-VGVEPRR 195

Query: 126 KVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPE 185
           +V  + G+ A T+Y  +    +    + ++  TGR+HQ+RVH+  L HP++GD+ Y  P 
Sbjct: 196 RVIAD-GQSAWTDYWRLAQD-ERLTVLKVQIHTGRTHQIRVHLSDLDHPLVGDQLYEGPL 253

Query: 186 ARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
                 R  LHA  LT   P       F AP  
Sbjct: 254 G-WGIDRQALHAYQLTFNDPFSQQKRQFTAPIP 285


>UniRef50_C4V3I7 Pseudouridine synthase n=1 Tax=Selenomonas flueggei ATCC 43531
           RepID=C4V3I7_9FIRM
          Length = 294

 Score =  244 bits (623), Expect = 2e-63,   Method: Composition-based stats.
 Identities = 71/219 (32%), Positives = 113/219 (51%), Gaps = 16/219 (7%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP------QAESVHR 62
           P+   L I+Y+DD ++V++KP+G L  P   E H  ++   ++  Y            HR
Sbjct: 72  PESLPLSIIYEDDDLLVLDKPAGQLVHPTTKETHG-TIANAVRGYYAACGVHLDFHPCHR 130

Query: 63  LDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNR 122
           LD  TSG++++A     + ++ +Q      +++Y+A + G  +P EG +D+P+    P+ 
Sbjct: 131 LDRNTSGLLLIAKHPEVQYQIAQQ---NTLRREYLALIAGSLTPPEGCIDVPIARALPSI 187

Query: 123 PKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYA 182
             + V  E GK A T Y  V+      + + L+  TGR+HQ+RVH+  LGHP+LGD  Y 
Sbjct: 188 ILRCVSTE-GKSACTHYVTVQTDG-RYSLLRLQLDTGRTHQIRVHLAHLGHPLLGDDLYG 245

Query: 183 SPEARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
               RA   R  LH+  LT+ HP     +   A  PAD 
Sbjct: 246 G--TRAEIARHALHSAHLTLVHPRTKKMLALSALLPADM 282


>UniRef50_B2J8D4 Pseudouridine synthase n=7 Tax=Cyanobacteria RepID=B2J8D4_NOSP7
          Length = 575

 Score =  244 bits (623), Expect = 2e-63,   Method: Composition-based stats.
 Identities = 88/212 (41%), Positives = 128/212 (60%), Gaps = 10/212 (4%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ---AESVHRLDMA 66
           +E  L I+Y+D+ ++ VNKP GLLSVPGR  + +DSV++R++   P      SVHRLD  
Sbjct: 364 EEVTLPIIYEDEWLIAVNKPPGLLSVPGRYRDRQDSVLSRLRHLLPDGMALASVHRLDQE 423

Query: 67  TSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQK 126
           TSG++++A  +   ++L +QF++R+  K Y A + G     +G++DLPL  D  NRP QK
Sbjct: 424 TSGILLLARDRQTHKQLSQQFQQRQVHKVYEAILSGVAIAEKGVIDLPLWGDPENRPYQK 483

Query: 127 VCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHML---ALGHPILGDRFYAS 183
           V ++ GKP+ T+++V+    D   R+   P+TGR+HQLRVH      LG  ILGDR Y  
Sbjct: 484 VDWQNGKPSLTQFQVISREQD-YTRIEFTPLTGRTHQLRVHAADVRGLGITILGDRLYGC 542

Query: 184 PEARAMAPRLLLHAEMLTITHPAYGNSMTFKA 215
               A+  RL LHA  L   HP    ++  KA
Sbjct: 543 D---AVTSRLYLHARELDFEHPQLKKTLYLKA 571


>UniRef50_Q8ZFU1 Ribosomal large subunit pseudouridine synthase C n=102
           Tax=Gammaproteobacteria RepID=RLUC_YERPE
          Length = 320

 Score =  244 bits (623), Expect = 2e-63,   Method: Composition-based stats.
 Identities = 74/212 (34%), Positives = 108/212 (50%), Gaps = 12/212 (5%)

Query: 16  ILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAE---SVHRLDMATSGVIV 72
           IL++DD+++V+NKPSG     G        V+  ++   P+A     VHRLD  TSGV++
Sbjct: 95  ILFEDDYLLVLNKPSGTAVHGGSGLSFG--VIEGLRALRPEARFLELVHRLDRDTSGVLL 152

Query: 73  VALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKV-CYET 131
           VA  ++A R L  Q R +  +K Y+A V G        +  PL+ +     ++ V     
Sbjct: 153 VAKKRSALRSLHEQLRLKSMQKDYLALVRGQWQSHCKAIQAPLLKNIMQSGERVVKVSSE 212

Query: 132 GKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPE-----A 186
           GKP++T +++ E   ++   V   P+TGR+HQ+RVH L  GHPI  D  Y   E      
Sbjct: 213 GKPSETRFKIEERF-EHATLVKASPVTGRTHQIRVHALHAGHPIAFDDRYGYREFDQQLQ 271

Query: 187 RAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
                RL LHA  L   HP  G +M  +AP D
Sbjct: 272 GTGLHRLFLHAAALRFEHPNTGETMRIEAPLD 303


>UniRef50_D1XZI5 Pseudouridine synthase n=1 Tax=Prevotella bivia JCVIHMP010
           RepID=D1XZI5_9BACT
          Length = 577

 Score =  244 bits (623), Expect = 2e-63,   Method: Composition-based stats.
 Identities = 84/218 (38%), Positives = 118/218 (54%), Gaps = 21/218 (9%)

Query: 12  PWLVILYQDDHIMVVNKPSGLLSVPGR-LEEHKDSVMTRIQRDYPQAESVHRLDMATSGV 70
             + IL++D+++ V++KP+GLLSVPG+ L     +++ +  +   +   VHRLDM TSG+
Sbjct: 360 IEIPILFEDNYLAVIDKPAGLLSVPGKKLATSVYALLKQKWQGRCKPYMVHRLDMDTSGL 419

Query: 71  IVVALTKAAERELKRQFREREPKKQYVA-----RVWGHPSPAEGLVDLPLICDWPNRPKQ 125
           +VVA       +L++QF  R   K+Y A      +  +  P  G + LPL  D  +RP+Q
Sbjct: 420 MVVAKQAHVYHDLQQQFINRTVNKRYTAFLPLSLLDKNLPPK-GKIILPLTADLFDRPRQ 478

Query: 126 KVCYETGKPAQTEYEVV------EYAADNTARVVLKPITGRSHQLRVHMLA---LGHPIL 176
           KV  E GK A T YE+V      E       RV+L P TGR+HQLRVH      LG PI+
Sbjct: 479 KVDKEVGKIAITTYEIVGKTHYGERLKQLAVRVLLYPHTGRTHQLRVHCAHSEGLGTPII 538

Query: 177 GDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFK 214
           GD  Y +      A RL L+A+ L   HP     MTF 
Sbjct: 539 GDNLYGNK-----ANRLHLYADRLRFVHPITHKEMTFS 571


>UniRef50_A9IIW7 Pseudouridine synthase n=5 Tax=Bordetella RepID=A9IIW7_BORPD
          Length = 324

 Score =  244 bits (623), Expect = 2e-63,   Method: Composition-based stats.
 Identities = 72/221 (32%), Positives = 105/221 (47%), Gaps = 14/221 (6%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP------QAESVHR 62
           P+     ++ +    +VV+KP+GL++ PG       +++  +   YP      +A  VHR
Sbjct: 94  PEPIAFAVVAESPDWIVVDKPAGLVTHPGAGNWSG-TLLNGLLHRYPELARVARAGIVHR 152

Query: 63  LDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNR 122
           LD  TSG++VVA  + A+  L RQ + R   ++Y+A   G   P  G VD P+  D    
Sbjct: 153 LDKDTSGLMVVARNELAQTHLVRQLQARSMGREYIALAHGWL-PVAGKVDRPIGRDARVP 211

Query: 123 PKQKVCYETG-KPAQTEYEVVEYAA---DNTARVVLKPITGRSHQLRVHMLALGHPILGD 178
            +  V      KPA T Y  +            V  +  TGR+HQ+RVH+ +LGHP+L D
Sbjct: 212 VRMSVERPIAPKPAITHYAPLRRGRAPDGPVTEVACRLETGRTHQIRVHLASLGHPLLAD 271

Query: 179 RFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKA-PAD 218
             Y      A A R +LHA  L    P  G    F+A P D
Sbjct: 272 TLYGGRLT-AGATRQMLHARALHFDDPGGGGPAAFRADPPD 311


>UniRef50_Q0F3G4 Pseudouridine synthase n=1 Tax=Mariprofundus ferrooxydans PV-1
           RepID=Q0F3G4_9PROT
          Length = 315

 Score =  243 bits (622), Expect = 3e-63,   Method: Composition-based stats.
 Identities = 78/214 (36%), Positives = 104/214 (48%), Gaps = 9/214 (4%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDMATSGVIVV 73
           + +LY+DD ++VVNKP+G++   G   E       +  R        HRLD  TSGV+++
Sbjct: 94  IPVLYEDDSLLVVNKPAGMVVHGGSGHEAGLIEALKQSRGLDDLRLAHRLDRDTSGVLLM 153

Query: 74  ALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRP-KQKVCYETG 132
           A    A R L   FRER+ +K Y A + GHP    G +   L         +  V  E G
Sbjct: 154 AKHLDALRRLTESFRERDMQKTYFALIAGHPYAHAGRMSSNLAKGVVRGGERMVVDSEEG 213

Query: 133 KPAQTEYEVV---EYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARA- 188
           K + T+Y+V+   E      A V L P +GR+HQLRV +   GHPILGD  Y      A 
Sbjct: 214 KASVTDYQVMIEYERHGFPYAMVALNPHSGRTHQLRVQLQHEGHPILGDGKYGEKAQLAA 273

Query: 189 ----MAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
                   L+LHA  L  THP  G S+  KAP  
Sbjct: 274 YKSLGGKGLMLHAWRLRFTHPVSGKSLECKAPWP 307


>UniRef50_Q2RQY9 Pseudouridine synthase n=3 Tax=Alphaproteobacteria
           RepID=Q2RQY9_RHORT
          Length = 330

 Score =  243 bits (622), Expect = 3e-63,   Method: Composition-based stats.
 Identities = 84/209 (40%), Positives = 110/209 (52%), Gaps = 7/209 (3%)

Query: 16  ILYQDDHIMVVNKPSGLLSVPGRL-EEHKDSVMTRIQRDYPQAESVHRLDMATSGVIVVA 74
           IL++D H++V+NK +GL    G     H D ++  +         VHRLD  TSGV+V+A
Sbjct: 96  ILHEDAHLIVINKEAGLAVQGGTGTPHHLDGMLESLADGGETPRLVHRLDKDTSGVLVLA 155

Query: 75  LTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRP-KQKVCYETGK 133
            T+AA R L   FR RE  K Y A V G P   +G +   L      R  + ++  E GK
Sbjct: 156 RTQAAARALTSAFRSREALKVYWAIVVGRPPMLQGTIKGALAKVAGGRGERMEINEEEGK 215

Query: 134 PAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASP----EARAM 189
            A T++ VV+ AA   A V L P TGR+HQLRVH L +G PILGD  Y  P    E   +
Sbjct: 216 RAVTDFRVVDQAAKACAWVELHPRTGRTHQLRVHCLEMGTPILGDGKYGGPGAFLEGTEL 275

Query: 190 APRLLLHAEMLTITHPAYGNSMTFKAPAD 218
             R+ LHA  L + HPA G  +   AP  
Sbjct: 276 PKRMHLHARALALPHPAGG-VLEIIAPPP 303


Searching..................................................done


Results from round 3


                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value
Sequences used in model and found again:

UniRef50_Q3ABZ7 Pseudouridine synthase n=2 Tax=Bacteria RepID=Q3...   345   4e-94
UniRef50_B0TGQ0 Pseudouridine synthase n=44 Tax=Bacteria RepID=B...   342   4e-93
UniRef50_B8FT16 Pseudouridine synthase n=70 Tax=Bacteria RepID=B...   339   6e-92
UniRef50_B9Y836 Pseudouridine synthase n=3 Tax=Firmicutes RepID=...   332   4e-90
UniRef50_C9KPZ8 Pseudouridine synthase n=1 Tax=Mitsuokella multa...   331   1e-89
UniRef50_C4FYR8 Pseudouridine synthase n=1 Tax=Abiotrophia defec...   329   6e-89
UniRef50_A9BFW4 Pseudouridine synthase n=8 Tax=Thermotogaceae Re...   328   9e-89
UniRef50_B2UL66 Pseudouridine synthase n=2 Tax=Verrucomicrobiace...   325   5e-88
UniRef50_P0AA37 Ribosomal large subunit pseudouridine synthase A...   325   7e-88
UniRef50_A3EQJ0 Pseudouridine synthase n=1 Tax=Leptospirillum ru...   324   2e-87
UniRef50_B8CWM0 Pseudouridine synthase n=1 Tax=Halothermothrix o...   324   2e-87
UniRef50_Q9JVB6 Ribosomal large subunit pseudouridine synthase D...   324   2e-87
UniRef50_Q45826 Uncharacterized RNA pseudouridine synthase Caur_...   324   2e-87
UniRef50_C7NAV5 Pseudouridine synthase n=5 Tax=Fusobacteriaceae ...   323   2e-87
UniRef50_C6XFD0 Pseudouridine synthase n=1 Tax=Candidatus Liberi...   323   2e-87
UniRef50_Q82WZ5 Ribosomal large subunit pseudouridine synthase D...   322   4e-87
UniRef50_B1I3F8 Pseudouridine synthase n=2 Tax=Bacteria RepID=B1...   322   6e-87
UniRef50_C8QZ10 Pseudouridine synthase n=1 Tax=Desulfurivibrio a...   322   8e-87
UniRef50_Q6AJM1 Pseudouridine synthase n=1 Tax=Desulfotalea psyc...   321   1e-86
UniRef50_B6AN83 Pseudouridine synthase n=2 Tax=Leptospirillum Re...   320   2e-86
UniRef50_C8NEP8 Pseudouridine synthase n=1 Tax=Granulicatella ad...   320   3e-86
UniRef50_B9L028 Pseudouridine synthase n=2 Tax=Thermomicrobia (c...   318   9e-86
UniRef50_Q2W2D5 Pseudouridine synthase n=39 Tax=Bacteria RepID=Q...   317   2e-85
UniRef50_A7HM17 Pseudouridine synthase n=2 Tax=Thermotogaceae Re...   317   3e-85
UniRef50_B2A2J2 Pseudouridine synthase n=1 Tax=Natranaerobius th...   315   5e-85
UniRef50_P50513 Ribosomal large subunit pseudouridine synthase D...   315   6e-85
UniRef50_C4FWV7 Pseudouridine synthase n=2 Tax=Firmicutes RepID=...   315   7e-85
UniRef50_C9LM35 Pseudouridine synthase n=1 Tax=Dialister invisus...   314   2e-84
UniRef50_C0BNA6 Pseudouridine synthase n=7 Tax=Bacteroidetes Rep...   312   4e-84
UniRef50_B8E0R4 Pseudouridine synthase n=1 Tax=Dictyoglomus turg...   312   7e-84
UniRef50_A9IQ66 Pseudouridine synthase n=5 Tax=Bacteria RepID=A9...   312   7e-84
UniRef50_B9JRD0 Pseudouridine synthase n=1 Tax=Agrobacterium vit...   311   8e-84
UniRef50_Q3A0C2 Pseudouridine synthase n=13 Tax=Bacteria RepID=Q...   311   1e-83
UniRef50_A3M2Y1 Pseudouridine synthase n=18 Tax=Gammaproteobacte...   311   1e-83
UniRef50_Q2SS88 Pseudouridine synthase n=4 Tax=Mollicutes RepID=...   311   1e-83
UniRef50_Q2LWV4 Pseudouridine synthase n=1 Tax=Syntrophus acidit...   311   1e-83
UniRef50_A5WFS2 Pseudouridine synthase n=3 Tax=Psychrobacter Rep...   310   1e-83
UniRef50_B8FLB4 Pseudouridine synthase n=2 Tax=Bacteria RepID=B8...   310   2e-83
UniRef50_D2BIX0 Pseudouridine synthase n=5 Tax=Dehalococcoides R...   309   3e-83
UniRef50_D1ANU4 Pseudouridine synthase n=14 Tax=Fusobacteriaceae...   309   5e-83
UniRef50_A6SXT6 Pseudouridine synthase n=1 Tax=Janthinobacterium...   309   5e-83
UniRef50_A0L9J0 Pseudouridine synthase n=1 Tax=Magnetococcus sp....   309   5e-83
UniRef50_C7RM94 Pseudouridine synthase n=11 Tax=Proteobacteria R...   309   6e-83
UniRef50_Q3AVX8 Pseudouridine synthase n=40 Tax=cellular organis...   308   1e-82
UniRef50_A9NGF1 Pseudouridine synthase n=1 Tax=Acholeplasma laid...   307   2e-82
UniRef50_D1PCC3 Pseudouridine synthase n=1 Tax=Prevotella copri ...   307   2e-82
UniRef50_A6C0W7 Pseudouridine synthase n=1 Tax=Planctomyces mari...   307   2e-82
UniRef50_A9BMW0 Pseudouridine synthase n=10 Tax=Comamonadaceae R...   307   2e-82
UniRef50_D0MJ49 Pseudouridine synthase n=2 Tax=Bacteria RepID=D0...   307   2e-82
UniRef50_Q49WX8 Pseudouridine synthase n=1 Tax=Staphylococcus sa...   307   2e-82
UniRef50_A1URK8 Pseudouridine synthase n=2 Tax=Bartonella RepID=...   306   3e-82
UniRef50_A7NB61 Pseudouridine synthase n=18 Tax=Francisella RepI...   306   3e-82
UniRef50_D1RB31 Pseudouridine synthase n=1 Tax=Parachlamydia aca...   306   3e-82
UniRef50_O50310 Uncharacterized RNA pseudouridine synthase Cpar_...   306   3e-82
UniRef50_A6DUC9 Pseudouridine synthase n=1 Tax=Lentisphaera aran...   305   5e-82
UniRef50_P74346 Uncharacterized RNA pseudouridine synthase slr16...   305   5e-82
UniRef50_A5GW76 Pseudouridine synthase n=1 Tax=Synechococcus sp....   304   1e-81
UniRef50_Q312A0 Pseudouridine synthase, RluD n=6 Tax=Bacteria Re...   304   2e-81
UniRef50_C6WV38 Pseudouridine synthase n=3 Tax=Proteobacteria Re...   304   2e-81
UniRef50_C6BSG2 Pseudouridine synthase, RluA family n=1 Tax=Desu...   303   2e-81
UniRef50_C7H7W3 Ribosomal large subunit pseudouridine synthase D...   303   2e-81
UniRef50_A7HV45 Pseudouridine synthase n=56 Tax=Alphaproteobacte...   303   2e-81
UniRef50_P65834 Ribosomal large subunit pseudouridine synthase D...   303   3e-81
UniRef50_B8K915 Pseudouridine synthase n=5 Tax=Vibrio RepID=B8K9...   303   3e-81
UniRef50_D1BAB3 Pseudouridine synthase n=1 Tax=Thermanaerovibrio...   302   6e-81
UniRef50_C8PVB8 Pseudouridine synthase n=2 Tax=Moraxellaceae Rep...   302   7e-81
UniRef50_D0RPR1 Pseudouridine synthase n=1 Tax=alpha proteobacte...   301   9e-81
UniRef50_D2L0S2 Pseudouridine synthase, RluA family n=1 Tax=Desu...   301   1e-80
UniRef50_Q8XYX8 Ribosomal large subunit pseudouridine synthase D...   301   1e-80
UniRef50_A4WSV2 Pseudouridine synthase n=41 Tax=Alphaproteobacte...   300   2e-80
UniRef50_D1VS73 Pseudouridine synthase n=1 Tax=Peptoniphilus lac...   300   2e-80
UniRef50_Q87AR7 Ribosomal large subunit pseudouridine synthase D...   300   2e-80
UniRef50_C6XNC0 Pseudouridine synthase n=1 Tax=Hirschia baltica ...   300   2e-80
UniRef50_C8WW59 Pseudouridine synthase n=2 Tax=Alicyclobacillus ...   299   4e-80
UniRef50_B8GZR6 Pseudouridine synthase n=2 Tax=Caulobacter vibri...   299   4e-80
UniRef50_B9YI75 Pseudouridine synthase, RluA family n=1 Tax='Nos...   299   4e-80
UniRef50_Q1MQ60 Pseudouridylate synthases, 23S RNA-specific n=1 ...   298   6e-80
UniRef50_C5VRN0 Pseudouridine synthase n=1 Tax=Clostridium botul...   298   6e-80
UniRef50_A8GQ59 Pseudouridine synthase n=15 Tax=Rickettsia RepID...   298   8e-80
UniRef50_D0KVM5 Pseudouridine synthase n=11 Tax=Proteobacteria R...   298   9e-80
UniRef50_Q1ILA4 Pseudouridine synthase n=1 Tax=Candidatus Koriba...   298   1e-79
UniRef50_C9RQF0 Pseudouridine synthase, RluA family n=1 Tax=Fibr...   297   1e-79
UniRef50_C8P3R0 Pseudouridine synthase n=1 Tax=Erysipelothrix rh...   297   2e-79
UniRef50_B5YKV0 Pseudouridine synthase n=1 Tax=Thermodesulfovibr...   297   2e-79
UniRef50_Q01Q94 Pseudouridine synthase n=1 Tax=Candidatus Soliba...   296   3e-79
UniRef50_D1Y3Y9 Pseudouridine synthase n=1 Tax=Pyramidobacter pi...   296   4e-79
UniRef50_C8S0A2 Pseudouridine synthase n=1 Tax=Rhodobacter sp. S...   295   5e-79
UniRef50_P54604 Uncharacterized RNA pseudouridine synthase yhcT ...   295   5e-79
UniRef50_B8J173 Pseudouridine synthase, RluA family n=2 Tax=Desu...   295   5e-79
UniRef50_A8ZXZ8 Pseudouridine synthase n=1 Tax=Desulfococcus ole...   295   6e-79
UniRef50_A5EX53 Pseudouridine synthase n=1 Tax=Dichelobacter nod...   295   6e-79
UniRef50_D1U4S9 Pseudouridine synthase, RluA family n=1 Tax=Desu...   295   1e-78
UniRef50_C4XFS9 Pseudouridine synthase n=2 Tax=Mycoplasma RepID=...   294   1e-78
UniRef50_C0QAZ3 RluD1 n=1 Tax=Desulfobacterium autotrophicum HRM...   294   1e-78
UniRef50_Q8DCG0 Ribosomal large subunit pseudouridine synthase A...   294   2e-78
UniRef50_B2RIT5 Pseudouridine synthase n=80 Tax=root RepID=B2RIT...   294   2e-78
UniRef50_Q6MEC0 Pseudouridine synthase n=1 Tax=Candidatus Protoc...   293   2e-78
UniRef50_O67638 Uncharacterized RNA pseudouridine synthase aq_17...   293   2e-78
UniRef50_A9CFZ5 Pseudouridine synthase n=3 Tax=Rhizobiales RepID...   293   2e-78
UniRef50_Q03WF6 Pseudouridine synthase n=9 Tax=Firmicutes RepID=...   293   2e-78
UniRef50_Q4FN11 Pseudouridine synthase n=4 Tax=Bacteria RepID=Q4...   293   4e-78
UniRef50_C4XSN0 Ribosomal large subunit pseudouridine synthase D...   292   4e-78
UniRef50_C1FEQ4 Predicted protein n=2 Tax=Micromonas RepID=C1FEQ...   292   4e-78
UniRef50_Q13E92 Pseudouridine synthase n=28 Tax=Alphaproteobacte...   292   5e-78
UniRef50_C0QPR5 Pseudouridine synthase n=4 Tax=Hydrogenothermace...   292   6e-78
UniRef50_D0J9U5 Pseudouridine synthase n=2 Tax=Blattabacterium R...   292   6e-78
UniRef50_C0ZH07 Pseudouridine synthase n=1 Tax=Brevibacillus bre...   292   7e-78
UniRef50_B0VJ94 Pseudouridine synthase n=1 Tax=Candidatus Cloaca...   292   8e-78
UniRef50_C1SM47 Pseudouridine synthase n=1 Tax=Denitrovibrio ace...   291   1e-77
UniRef50_Q1Q689 Similar to ribosomal large subunit pseudouridine...   291   1e-77
UniRef50_C6LL16 Pseudouridine synthase n=3 Tax=Clostridiales Rep...   290   2e-77
UniRef50_C6CWL6 Pseudouridine synthase n=2 Tax=Paenibacillus Rep...   290   2e-77
UniRef50_C7LWM1 Pseudouridine synthase, RluA family n=1 Tax=Desu...   290   2e-77
UniRef50_C1A885 Pseudouridine synthase n=1 Tax=Gemmatimonas aura...   290   3e-77
UniRef50_Q0BWH2 Pseudouridine synthase n=3 Tax=Alphaproteobacter...   290   3e-77
UniRef50_A7K2Y9 Pseudouridine synthase n=4 Tax=Vibrio RepID=A7K2...   290   3e-77
UniRef50_A3RGY8 Pseudouridine synthase n=1 Tax=uncultured bacter...   290   3e-77
UniRef50_Q2S3B7 Pseudouridine synthase n=1 Tax=Salinibacter rube...   289   4e-77
UniRef50_B1ZYX0 Pseudouridine synthase n=4 Tax=Verrucomicrobia R...   289   4e-77
UniRef50_A1AW00 Pseudouridine synthase n=2 Tax=sulfur-oxidizing ...   288   6e-77
UniRef50_A3MZ33 Pseudouridine synthase n=9 Tax=Proteobacteria Re...   288   6e-77
UniRef50_D2R7T3 Pseudouridine synthase, RluA family n=1 Tax=Pire...   288   6e-77
UniRef50_C1F7V3 Pseudouridine synthase n=1 Tax=Acidobacterium ca...   288   7e-77
UniRef50_C1ZGS9 Pseudouridine synthase n=1 Tax=Planctomyces limn...   288   7e-77
UniRef50_Q7UHX8 Pseudouridine synthase n=1 Tax=Rhodopirellula ba...   288   8e-77
UniRef50_A6LDZ7 Pseudouridine synthase n=26 Tax=Bacteroidales Re...   288   8e-77
UniRef50_A0Q1S9 Pseudouridine synthase n=32 Tax=Clostridium RepI...   288   8e-77
UniRef50_UPI0001C42CC7 hypothetical protein BpOF4_01845 n=1 Tax=...   288   9e-77
UniRef50_C9M7B4 Pseudouridine synthase n=1 Tax=Jonquetella anthr...   288   1e-76
UniRef50_C0QV86 Pseudouridine synthase n=2 Tax=Brachyspira RepID...   288   1e-76
UniRef50_A5IZB6 Pseudouridine synthase n=4 Tax=Mycoplasma RepID=...   287   1e-76
UniRef50_A0LPH5 Pseudouridine synthase n=1 Tax=Syntrophobacter f...   287   1e-76
UniRef50_Q0F3G2 Possible pseudouridine synthase n=1 Tax=Mariprof...   287   2e-76
UniRef50_B7GLK3 Pseudouridine synthase n=11 Tax=Bacillaceae RepI...   287   2e-76
UniRef50_C6JBH1 Pseudouridine synthase n=1 Tax=Ruminococcus sp. ...   287   2e-76
UniRef50_Q2GGY1 Pseudouridine synthase n=13 Tax=Rickettsiales Re...   287   2e-76
UniRef50_C6J6E3 Pseudouridine synthase n=2 Tax=Bacillales RepID=...   286   3e-76
UniRef50_A6NQQ9 Pseudouridine synthase n=1 Tax=Bacteroides capil...   286   3e-76
UniRef50_B6BTN1 Pseudouridine synthase n=2 Tax=Betaproteobacteri...   286   3e-76
UniRef50_Q63E77 Pseudouridine synthase n=73 Tax=Bacillaceae RepI...   286   3e-76
UniRef50_B7GEZ0 Pseudouridine synthase n=7 Tax=Bacillaceae RepID...   286   3e-76
UniRef50_Q5PAD0 Pseudouridine synthase n=5 Tax=Anaplasma RepID=Q...   286   4e-76
UniRef50_Q2NIN6 Pseudouridine synthase n=4 Tax=Candidatus Phytop...   286   4e-76
UniRef50_A5IBH6 Pseudouridine synthase n=6 Tax=Legionella RepID=...   285   5e-76
UniRef50_Q1J0S8 Pseudouridine synthase n=7 Tax=Deinococci RepID=...   285   5e-76
UniRef50_UPI00016C3FBA ribosomal large subunit pseudouridine syn...   285   7e-76
UniRef50_Q2CAH0 Pseudouridine synthase n=3 Tax=Proteobacteria Re...   285   7e-76
UniRef50_B8CWB7 Pseudouridine synthase n=1 Tax=Halothermothrix o...   285   7e-76
UniRef50_B3DV48 Pseudouridine synthase n=1 Tax=Methylacidiphilum...   285   9e-76
UniRef50_B6J6C4 Pseudouridine synthase n=7 Tax=Coxiella burnetii...   285   1e-75
UniRef50_A1HR26 Pseudouridine synthase, RluA family n=1 Tax=Ther...   284   1e-75
UniRef50_D1N7N8 Pseudouridine synthase, RluA family n=1 Tax=Vict...   284   1e-75
UniRef50_C0GNZ6 Pseudouridine synthase, RluA family n=1 Tax=Desu...   284   1e-75
UniRef50_C5J6Q2 Pseudouridine synthase n=1 Tax=Mycoplasma conjun...   284   2e-75
UniRef50_D1AV01 Pseudouridine synthase n=2 Tax=Bacteria RepID=D1...   283   2e-75
UniRef50_A4RT55 Predicted protein (Fragment) n=3 Tax=Chlorophyta...   283   2e-75
UniRef50_C8X1I9 Pseudouridine synthase, RluA family n=1 Tax=Desu...   283   3e-75
UniRef50_A8MF48 Pseudouridine synthase n=12 Tax=Clostridiaceae R...   283   3e-75
UniRef50_Q489H0 Pseudouridine synthase n=3 Tax=Gammaproteobacter...   282   5e-75
UniRef50_B0K860 Pseudouridine synthase n=11 Tax=Thermoanaerobact...   282   5e-75
UniRef50_C2W5F3 Pseudouridine synthase n=4 Tax=Bacillus RepID=C2...   282   6e-75
UniRef50_Q14NK8 Probable pseudouridine synthase d protein n=1 Ta...   282   6e-75
UniRef50_C0ZCK6 Pseudouridine synthase n=1 Tax=Brevibacillus bre...   282   8e-75
UniRef50_A4VJG2 Pseudouridine synthase n=18 Tax=Bacteria RepID=A...   281   1e-74
UniRef50_Q6MGX8 Pseudouridine synthase n=1 Tax=Bdellovibrio bact...   281   1e-74
UniRef50_A5VJ18 Pseudouridine synthase, RluA family n=13 Tax=Lac...   281   1e-74
UniRef50_C7LVL1 Pseudouridine synthase n=5 Tax=Proteobacteria Re...   280   2e-74
UniRef50_D1CBT6 Pseudouridine synthase n=1 Tax=Thermobaculum ter...   280   2e-74
UniRef50_Q8K9E9 Ribosomal large subunit pseudouridine synthase D...   280   2e-74
UniRef50_C1CWT3 Pseudouridine synthase n=1 Tax=Deinococcus deser...   280   3e-74
UniRef50_B7HGW1 Pseudouridine synthase n=52 Tax=Bacillales RepID...   280   3e-74
UniRef50_B8FTI5 Pseudouridine synthase n=2 Tax=Desulfitobacteriu...   280   3e-74
UniRef50_O31613 Uncharacterized RNA pseudouridine synthase yjbO ...   279   3e-74
UniRef50_P59838 Ribosomal large subunit pseudouridine synthase D...   279   4e-74
UniRef50_D2RBY1 Pseudouridine synthase, RluA family n=1 Tax=Gard...   278   8e-74
UniRef50_B7BE87 Pseudouridine synthase n=8 Tax=Bacteroidales Rep...   278   1e-73
UniRef50_P59831 Ribosomal large subunit pseudouridine synthase A...   277   1e-73
UniRef50_Q28K21 Pseudouridine synthase n=11 Tax=Proteobacteria R...   277   1e-73
UniRef50_C8NZX3 Pseudouridine synthase n=1 Tax=Erysipelothrix rh...   277   2e-73
UniRef50_Q0VQA6 Pseudouridine synthase n=7 Tax=Gammaproteobacter...   276   3e-73
UniRef50_A6TSZ4 Pseudouridine synthase n=1 Tax=Alkaliphilus meta...   275   6e-73
UniRef50_Q8ERS8 Pseudouridine synthase n=2 Tax=Bacillaceae RepID...   275   6e-73
UniRef50_C0EHV8 Putative uncharacterized protein n=1 Tax=Clostri...   275   9e-73
UniRef50_B4U613 Pseudouridine synthase, RluA family n=1 Tax=Hydr...   274   1e-72
UniRef50_C7MN62 Pseudouridine synthase n=8 Tax=Coriobacteriaceae...   274   1e-72
UniRef50_C0MA80 Pseudouridine synthase n=6 Tax=Streptococcus Rep...   274   1e-72
UniRef50_A4J479 Pseudouridine synthase n=1 Tax=Desulfotomaculum ...   274   2e-72
UniRef50_C2D7A7 Pseudouridine synthase n=1 Tax=Atopobium vaginae...   273   3e-72
UniRef50_D2M2K8 Pseudouridine synthase, RluA family n=1 Tax=Baci...   273   3e-72
UniRef50_A3DDK9 Pseudouridine synthase, RluA family n=3 Tax=Clos...   273   4e-72
UniRef50_C5RBB6 23S rRNA pseudouridylate synthase RluD n=1 Tax=W...   273   4e-72
UniRef50_A8RHQ2 Pseudouridine synthase n=2 Tax=Clostridium RepID...   273   4e-72
UniRef50_B8I750 Pseudouridine synthase, RluA family n=2 Tax=Clos...   272   5e-72
UniRef50_C0Z877 Pseudouridine synthase n=1 Tax=Brevibacillus bre...   272   5e-72
UniRef50_C2L1H2 Pseudouridine synthase n=1 Tax=Oribacterium sinu...   272   6e-72
UniRef50_Q1WS43 Pseudouridine synthase n=3 Tax=Lactobacillus Rep...   272   6e-72
UniRef50_B8DF66 Pseudouridine synthase n=18 Tax=Listeria RepID=B...   272   8e-72
UniRef50_A4J9H9 Pseudouridine synthase n=2 Tax=Clostridiales Rep...   272   9e-72
UniRef50_A5ZUU7 Pseudouridine synthase n=1 Tax=Ruminococcus obeu...   271   1e-71
UniRef50_B1XXM0 Pseudouridine synthase n=6 Tax=Burkholderiales R...   271   1e-71
UniRef50_A8UMR7 Pseudouridine synthase n=1 Tax=Flavobacteriales ...   270   2e-71
UniRef50_Q12L72 Pseudouridine synthase n=17 Tax=Shewanella RepID...   270   2e-71
UniRef50_Q89AD9 Ribosomal large subunit pseudouridine synthase D...   270   3e-71
UniRef50_B9DS29 Pseudouridine synthase n=85 Tax=Firmicutes RepID...   269   6e-71
UniRef50_Q5E092 Pseudouridine synthase n=3 Tax=Aliivibrio RepID=...   268   7e-71
UniRef50_D1W0M0 Pseudouridine synthase n=1 Tax=Prevotella timone...   268   7e-71
UniRef50_D0MK65 Pseudouridine synthase n=1 Tax=Rhodothermus mari...   268   8e-71
UniRef50_C5WJF2 Pseudouridine synthase n=104 Tax=Lactobacillales...   268   9e-71
UniRef50_Q1CZL9 Pseudouridine synthase n=5 Tax=Proteobacteria Re...   268   1e-70
UniRef50_B7GAM3 Predicted protein (Fragment) n=1 Tax=Phaeodactyl...   268   1e-70
UniRef50_C7GZW0 Pseudouridine synthase n=1 Tax=Eubacterium saphe...   268   1e-70
UniRef50_Q38W13 Pseudouridine synthase n=4 Tax=Lactobacillus Rep...   268   1e-70
UniRef50_C0E4Q3 Pseudouridine synthase n=2 Tax=Corynebacterium m...   268   1e-70
UniRef50_A9IIW7 Pseudouridine synthase n=5 Tax=Bordetella RepID=...   267   1e-70
UniRef50_B0JGC2 Pseudouridine synthase n=2 Tax=Microcystis aerug...   267   2e-70
UniRef50_B7GQ28 Pseudouridine synthase, RluA family n=21 Tax=Bif...   267   2e-70
UniRef50_B1XN95 Pseudouridine synthase n=1 Tax=Synechococcus sp....   267   2e-70
UniRef50_C8PT91 Ribosomal large subunit pseudouridine synthase D...   267   3e-70
UniRef50_D1PDP7 Pseudouridine synthase n=1 Tax=Prevotella copri ...   267   3e-70
UniRef50_P70870 Ribosomal large subunit pseudouridine synthase D...   266   3e-70
UniRef50_B5Y8D7 Pseudouridine synthase n=1 Tax=Coprothermobacter...   266   3e-70
UniRef50_UPI0001C37137 ribosomal large subunit pseudouridine syn...   266   4e-70
UniRef50_B2KBB0 Pseudouridine synthase n=1 Tax=Elusimicrobium mi...   266   4e-70
UniRef50_Q26D11 Pseudouridine synthase n=2 Tax=Flavobacteria Rep...   266   4e-70
UniRef50_C9KIU1 Pseudouridine synthase n=3 Tax=Veillonellaceae R...   266   4e-70
UniRef50_A0YGE0 Pseudouridine synthase n=1 Tax=marine gamma prot...   266   4e-70
UniRef50_Q31HX2 Pseudouridine synthase n=1 Tax=Thiomicrospira cr...   266   5e-70
UniRef50_Q04XF3 Pseudouridylate synthase, 23S RNA-specific n=4 T...   265   6e-70
UniRef50_Q0F1Z5 Pseudouridine synthase n=1 Tax=Mariprofundus fer...   265   7e-70
UniRef50_A9MGU8 Pseudouridine synthase n=1 Tax=Salmonella enteri...   265   8e-70
UniRef50_C1ZB48 Pseudouridine synthase, RluA family n=1 Tax=Plan...   265   9e-70
UniRef50_A3ZV48 Pseudouridine synthase n=1 Tax=Blastopirellula m...   265   9e-70
UniRef50_C7PHX6 Pseudouridine synthase n=1 Tax=Chitinophaga pine...   265   9e-70
UniRef50_D2EJM0 Pseudouridine synthase n=1 Tax=Pediococcus acidi...   265   1e-69
UniRef50_D0BL50 Pseudouridine synthase n=1 Tax=Granulicatella el...   265   1e-69
UniRef50_A5VLP2 Pseudouridine synthase, RluA family n=13 Tax=Lac...   264   1e-69
UniRef50_D2RJC8 Pseudouridine synthase, RluA family n=2 Tax=Veil...   264   1e-69
UniRef50_D2ELJ1 Pseudouridine synthase n=1 Tax=Pediococcus acidi...   264   2e-69
UniRef50_C0X7U3 Pseudouridine synthase n=21 Tax=Enterococcus fae...   264   2e-69
UniRef50_C1AE05 Pseudouridine synthase n=1 Tax=Gemmatimonas aura...   263   2e-69
UniRef50_C7QW59 Pseudouridine synthase n=5 Tax=Cyanobacteria Rep...   263   2e-69
UniRef50_Q83G23 Pseudouridine synthase n=2 Tax=Tropheryma whippl...   263   2e-69
UniRef50_Q9KQH0 Ribosomal large subunit pseudouridine synthase C...   263   2e-69
UniRef50_Q31NG5 Pseudouridine synthase n=2 Tax=Synechococcus elo...   263   3e-69
UniRef50_Q4A7R4 Pseudouridine synthase n=5 Tax=Mycoplasma hyopne...   263   3e-69
UniRef50_D1PU24 Pseudouridine synthase n=1 Tax=Prevotella bergen...   263   3e-69
UniRef50_Q8ZQ16 Ribosomal large subunit pseudouridine synthase C...   263   3e-69

Sequences not found previously or not previously below threshold:

UniRef50_Q3ECD0 RNA pseudourine synthase 2, chloroplastic n=4 Ta...   274   1e-72
UniRef50_Q5Z8P2 RNA pseudourine synthase 2, chloroplastic n=6 Ta...   273   3e-72
UniRef50_B6TXP4 RNA binding protein n=3 Tax=Poaceae RepID=B6TXP4...   270   2e-71

>UniRef50_Q3ABZ7 Pseudouridine synthase n=2 Tax=Bacteria RepID=Q3ABZ7_CARHZ
          Length = 305

 Score =  345 bits (888), Expect = 4e-94,   Method: Composition-based stats.
 Identities = 76/223 (34%), Positives = 110/223 (49%), Gaps = 9/223 (4%)

Query: 4   ENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYP 55
           E    P+E  L I+Y+D+ ++VVNK +G++  P         V   +             
Sbjct: 72  ELSVKPEEIPLDIVYEDEDLVVVNKKAGMVVHPAEGNWDGTLVNALLYHCQNLSGIGGVL 131

Query: 56  QAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPL 115
           +   VHRLD  TSG++VVA    A + L  Q +E++  ++Y   V G+    EG++DLP+
Sbjct: 132 RPGIVHRLDKDTSGLLVVAKNDLAHQSLAEQIKEKKAVREYWTIVHGYLKNKEGIIDLPI 191

Query: 116 ICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPI 175
                +R K  V    GK AQT Y+V+E        +  K +TGR+HQ+RVH   LGHP+
Sbjct: 192 GRHPRDRQKMAVVS-NGKTAQTVYKVLEEFNKGFTLIQAKLLTGRTHQIRVHFSYLGHPV 250

Query: 176 LGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           LGD  Y          R +LHA  L+  HP  G  + F AP  
Sbjct: 251 LGDPKYGHQNNPFGVKRQMLHAIKLSFIHPRSGELLEFTAPLP 293


>UniRef50_B0TGQ0 Pseudouridine synthase n=44 Tax=Bacteria RepID=B0TGQ0_HELMI
          Length = 369

 Score =  342 bits (880), Expect = 4e-93,   Method: Composition-based stats.
 Identities = 69/222 (31%), Positives = 104/222 (46%), Gaps = 12/222 (5%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYPQAESV 60
           P++  L I++QD  I V+NKP+GL+  P         V   +             +   V
Sbjct: 107 PEDIPLEIIFQDADIAVINKPAGLVVHPAEGHWSGTLVNALLYHIKDLSGINGELRPGIV 166

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HR+D  TSG++VVA    A   L  Q ++   +++Y+A V G      G V+ P+  D  
Sbjct: 167 HRIDKDTSGLLVVAKNDRAHIHLTEQVKDHRVRREYLAVVHGVIGAETGRVEAPIGRDPK 226

Query: 121 NRPKQKVCYETGKPAQTEYEVVEYAAD-NTARVVLKPITGRSHQLRVHMLALGHPILGDR 179
           +R +  V    GK A T + V+    +   + +  +  TGR+HQ+RVH+  +GHP+ GD 
Sbjct: 227 DRQRMAVI-AGGKSAITHFRVLARYPEQGFSLLHCRLETGRTHQIRVHLAHIGHPVAGDP 285

Query: 180 FYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
            Y   +A        LHA  L   HP  G  M F+A  P  F
Sbjct: 286 KYGPRKAAFGLTGQALHAWKLEFVHPRSGEPMRFQADPPEPF 327


>UniRef50_B8FT16 Pseudouridine synthase n=70 Tax=Bacteria RepID=B8FT16_DESHD
          Length = 334

 Score =  339 bits (870), Expect = 6e-92,   Method: Composition-based stats.
 Identities = 74/222 (33%), Positives = 106/222 (47%), Gaps = 9/222 (4%)

Query: 4   ENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYP 55
           E     +   L ILY+D+ ++VVNK  G++  P      K  V   +             
Sbjct: 97  ELKVEAENIPLEILYEDEDVLVVNKSQGMVVHPAPGAWTKTLVNALLYHCRNLSGINGVL 156

Query: 56  QAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPL 115
           +   VHR+D  TSG++VVA    A + L  Q +     ++Y+A V G      G V+ P+
Sbjct: 157 RPGIVHRIDKDTSGLLVVAKNDLAHQGLAEQIKAHSMARRYLAIVHGVVFEPSGTVEAPI 216

Query: 116 ICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPI 175
             D  +R K  V ++  K A T YEV+E   D    +  +  TGR+HQ+RVHM  L HP+
Sbjct: 217 GRDPADRKKMAVVFQNAKEAVTHYEVLERFRD-FTLLEARLETGRTHQIRVHMAYLKHPV 275

Query: 176 LGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPA 217
           LGD  Y   +        +LHA++L   HP  G  M F APA
Sbjct: 276 LGDPLYGPRKNPFGLQGQMLHAQLLGFQHPRSGEYMEFSAPA 317


>UniRef50_B9Y836 Pseudouridine synthase n=3 Tax=Firmicutes RepID=B9Y836_9FIRM
          Length = 307

 Score =  332 bits (854), Expect = 4e-90,   Method: Composition-based stats.
 Identities = 77/219 (35%), Positives = 111/219 (50%), Gaps = 10/219 (4%)

Query: 8   PPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYPQAES 59
            PQE  L ++Y+D  ++V+NKP GL+  PG        V   +             +   
Sbjct: 74  QPQEMALNVVYEDHDVIVINKPKGLVVHPGPGNPDHTLVNGLLWHCHDLSGINGVLRPGI 133

Query: 60  VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDW 119
           VHR+D  TSG+IV      A + L +Q  E+   +QY A V G  +   G +D P+  D 
Sbjct: 134 VHRIDKDTSGLIVACKNDNAHQSLAKQLAEKTAGRQYYALVHGVINHEYGTIDAPIGRDE 193

Query: 120 PNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDR 179
            +R K  V  +  +PA T ++VVE   DN   V  +  TGR+HQ+RVHM  +G PI+GD 
Sbjct: 194 KDRQKMAVTEKNSRPAITHFKVVERF-DNYTLVSCRLETGRTHQIRVHMQYIGFPIVGDP 252

Query: 180 FYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
            Y+  +        +LHA  L+ THP+ G  MTF+AP  
Sbjct: 253 KYSLRKTLPT-QGQMLHAYQLSFTHPSTGERMTFEAPLP 290


>UniRef50_C9KPZ8 Pseudouridine synthase n=1 Tax=Mitsuokella multacida DSM 20544
           RepID=C9KPZ8_9FIRM
          Length = 308

 Score =  331 bits (850), Expect = 1e-89,   Method: Composition-based stats.
 Identities = 74/219 (33%), Positives = 105/219 (47%), Gaps = 10/219 (4%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYPQAESV 60
           P++  L ILY+D  I+V+NK  G++  P         V   +             +   V
Sbjct: 75  PEDIPLDILYEDSDIIVINKARGMVVHPATGIYTGTLVNALLYHCKDLSGINGEIRPGIV 134

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLD  TSGV+V A   AA  +L  Q R +   + Y A V G+     G++   +     
Sbjct: 135 HRLDKDTSGVMVAAKNDAAHLDLAEQIRTKAAHRIYRAIVCGNIREEAGVIKGDIGRHPT 194

Query: 121 NRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRF 180
           +R K  + +E GKPA T + V+E        V  +  TGR+HQ+RVHM ++GHP+LGD  
Sbjct: 195 DRKKMAIVHEHGKPAVTHFRVLERFGA-YTLVECRLETGRTHQIRVHMASIGHPVLGDPK 253

Query: 181 YASPEARAM-APRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           Y   +A         LH+  LT+THP     MTF AP  
Sbjct: 254 YGPRKACPFAIKGQALHSLQLTLTHPRTREVMTFTAPLP 292


>UniRef50_C4FYR8 Pseudouridine synthase n=1 Tax=Abiotrophia defectiva ATCC 49176
           RepID=C4FYR8_ABIDE
          Length = 326

 Score =  329 bits (844), Expect = 6e-89,   Method: Composition-based stats.
 Identities = 73/228 (32%), Positives = 108/228 (47%), Gaps = 14/228 (6%)

Query: 4   ENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR---------DY 54
           E    P+   L ILY+D+ ++++NKP G++  P         V   +             
Sbjct: 89  EAEIIPENIPLDILYEDEDVILINKPKGMVVHPAAGHYTGTLVNALMYHCRDNLSGINGE 148

Query: 55  PQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLP 114
            +   VHR+DM T+GVI+      + R +  Q +E   K++Y A V+G     EG ++  
Sbjct: 149 LRPGIVHRIDMDTTGVIIACKNDVSHRIIAEQLKEHSIKRKYQAIVYGVFKDEEGRIEGS 208

Query: 115 LICDWPNRPKQKVCYETGKPAQTEYEVVEYA----ADNTARVVLKPITGRSHQLRVHMLA 170
           +     +R K  V    GKPA T Y V+        +N A +  +  TGR+HQ+RVHM +
Sbjct: 209 IGRSKTDRKKMAVI-PDGKPAVTHYRVIRNYTSPNGNNFAHIECELETGRTHQIRVHMTS 267

Query: 171 LGHPILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           +GHP+LGD  Y + +         LHAEML   HP  G  M F AP  
Sbjct: 268 IGHPLLGDEIYGAAKNPFKLDGQALHAEMLGFVHPRTGEYMEFHAPLP 315


>UniRef50_A9BFW4 Pseudouridine synthase n=8 Tax=Thermotogaceae RepID=A9BFW4_PETMO
          Length = 319

 Score =  328 bits (842), Expect = 9e-89,   Method: Composition-based stats.
 Identities = 78/228 (34%), Positives = 112/228 (49%), Gaps = 14/228 (6%)

Query: 4   ENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR---------DY 54
           E    P+   L ILY+D+ ++V+NKP+GL+  P    +    V   +           D 
Sbjct: 75  EENILPENIPLNILYEDEELIVINKPAGLIVHPTPSIKTGTLVNALMHHVKDLDKTMQDP 134

Query: 55  PQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLP 114
            +   VHRLD  TSGV+VVA    +   L ++F+ER+  K Y+A V G     EG ++LP
Sbjct: 135 NRLGIVHRLDKETSGVLVVAKNAFSHHLLSKEFKERKTMKYYLAIVEGTLKEKEGEINLP 194

Query: 115 LICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHP 174
           L      R K+ V Y  GK A TEY+ ++   D    V ++  TGR+HQ+RVH   +G+P
Sbjct: 195 LGRHPILRHKRAVVY-NGKEAITEYKTLKEFGDLATLVWIRLRTGRTHQIRVHFKYIGNP 253

Query: 175 ILGDRFYASPEARAMAP----RLLLHAEMLTITHPAYGNSMTFKAPAD 218
           ++GD  Y   +          R +LHA  L   HP     M F AP  
Sbjct: 254 LIGDSLYGKNKIEKNLQIPVGRQMLHALKLGFYHPKTKEWMEFLAPLP 301


>UniRef50_B2UL66 Pseudouridine synthase n=2 Tax=Verrucomicrobiaceae
           RepID=B2UL66_AKKM8
          Length = 323

 Score =  325 bits (836), Expect = 5e-88,   Method: Composition-based stats.
 Identities = 81/222 (36%), Positives = 115/222 (51%), Gaps = 11/222 (4%)

Query: 8   PPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYPQAES 59
            PQ+  L ILY+D+ ++V+NK SG++  P         V   +             +   
Sbjct: 71  QPQDIPLDILYEDEDVVVINKESGMVVHPAAGNPDGTIVNALLHHCGDLSGIGGVERPGI 130

Query: 60  VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDW 119
           VHRLD  TSG +V+A    A + L  QF  R  +K+Y+A V G PS + G V   +    
Sbjct: 131 VHRLDKDTSGCLVIAKNDGAHQSLTAQFAARSTEKRYLAVVQGIPSQSSGTVFTHIGRHP 190

Query: 120 PNRPKQKVCYET-GKPAQTEYEVV-EYAADNTARVVLKPITGRSHQLRVHMLALGHPILG 177
            NR K  V     GK A T+Y+++    + +++ V+    TGR+HQ+RVHML LGHP++G
Sbjct: 191 VNRLKMAVVNPGSGKAAITDYDLLCADPSTDSSLVLCTLHTGRTHQIRVHMLYLGHPLIG 250

Query: 178 DRFYASPEARAMAP-RLLLHAEMLTITHPAYGNSMTFKAPAD 218
           D  YA P  +   P RL+LHA  L   HP  G  M F+AP  
Sbjct: 251 DPIYAKPARQKAKPGRLMLHAWRLGFDHPRTGKRMDFEAPVP 292


>UniRef50_P0AA37 Ribosomal large subunit pseudouridine synthase A n=205
           Tax=Proteobacteria RepID=RLUA_ECOLI
          Length = 219

 Score =  325 bits (835), Expect = 7e-88,   Method: Composition-based stats.
 Identities = 219/219 (100%), Positives = 219/219 (100%)

Query: 1   MGMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESV 60
           MGMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESV
Sbjct: 1   MGMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESV 60

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP
Sbjct: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120

Query: 121 NRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRF 180
           NRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRF
Sbjct: 121 NRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRF 180

Query: 181 YASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
           YASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF
Sbjct: 181 YASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219


>UniRef50_A3EQJ0 Pseudouridine synthase n=1 Tax=Leptospirillum rubarum
           RepID=A3EQJ0_9BACT
          Length = 339

 Score =  324 bits (831), Expect = 2e-87,   Method: Composition-based stats.
 Identities = 76/232 (32%), Positives = 114/232 (49%), Gaps = 22/232 (9%)

Query: 8   PPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------------- 52
            P+   L ILY+D+ ++V++KP GL+  P         V   +                 
Sbjct: 89  QPENIRLEILYEDEDLIVISKPPGLVVHPAPGHSSGTLVNGLLFHFQSQGDEQKKGEPEE 148

Query: 53  -----DYPQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPA 107
                   +A  VHRLD  TSGV+VV  T++   +L  QF++R   K+Y+A V G     
Sbjct: 149 EEEAERPLRAGLVHRLDQDTSGVMVVGKTESVVLDLMNQFKDRSVSKKYLALVKGILPKK 208

Query: 108 EGLVDLPLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVH 167
            G ++ P+     +R K  V  + GKP+ T Y V+E   +N + + +  +TGR+HQ+RVH
Sbjct: 209 RGEINAPIGRSTHDRKKFTV-RQDGKPSVTRYRVLETYHENYSLLEVTLLTGRTHQIRVH 267

Query: 168 MLALGHPILGDRFYASP-EARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
              LG P+LGD  Y S        PR +LHA  L+  HP+  + M F+AP  
Sbjct: 268 FRYLGFPLLGDAVYGSKGTENKNFPRQMLHAWKLSFQHPSSNSKMEFEAPLP 319


>UniRef50_B8CWM0 Pseudouridine synthase n=1 Tax=Halothermothrix orenii H 168
           RepID=B8CWM0_HALOH
          Length = 308

 Score =  324 bits (831), Expect = 2e-87,   Method: Composition-based stats.
 Identities = 75/224 (33%), Positives = 111/224 (49%), Gaps = 9/224 (4%)

Query: 3   MENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DY 54
            ++   P E  L I+Y+D  I+V+NK +GL+  P         V   I            
Sbjct: 71  EDSGIKPVEMDLDIIYEDKDILVLNKNAGLVVHPAPGNHENTLVNALIAYCDNLSTISGV 130

Query: 55  PQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLP 114
            +   VHRLD  TSGV+V+A    + R+L  QF++R+ KK Y   + G     EG +D P
Sbjct: 131 NRPGIVHRLDKDTSGVMVIAKNDISHRKLVEQFKQRKTKKYYRTLLKGELPYKEGKIDAP 190

Query: 115 LICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHP 174
           +  D  +R K  V  +  K A T ++V+E+  D+ + V ++  TGR+HQ+RVH   +G P
Sbjct: 191 IGRDPHDRKKMAVTRKNSKKAVTYFKVLEFFRDH-SYVEVELKTGRTHQIRVHFSYMGFP 249

Query: 175 ILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           ++GD  Y     R  A R LLHA  L   HP     + +KA   
Sbjct: 250 VVGDSIYGKKRNRLQATRQLLHAYRLGFYHPRNDKWVEYKASLP 293


>UniRef50_Q9JVB6 Ribosomal large subunit pseudouridine synthase D n=39
           Tax=Proteobacteria RepID=RLUD_NEIMA
          Length = 374

 Score =  324 bits (831), Expect = 2e-87,   Method: Composition-based stats.
 Identities = 77/232 (33%), Positives = 112/232 (48%), Gaps = 17/232 (7%)

Query: 2   GMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR-----DYPQ 56
                  P+   L I+Y+DD ++VVNKP+GL+  P         +   +         P+
Sbjct: 93  EENLAFVPEPMALDIVYEDDTVIVVNKPAGLVVHPAAGNWTGTLLNGLLAHCPELSQIPR 152

Query: 57  AESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLI 116
           A  VHRLD  TSG++VVA T  A+  L  Q +ER  K+ Y A   G      G ++  + 
Sbjct: 153 AGIVHRLDKETSGLMVVAKTLPAQNSLVWQLQERTVKRIYRAVANGIVPFD-GKIETQIG 211

Query: 117 CDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPIL 176
            D  NR K  V    GKPA T  +V+E    + + +     TGR+HQ+RVHM    HP+ 
Sbjct: 212 RDPHNRLKMAVVKFGGKPAVTHVKVLERYLAH-SYIECSLETGRTHQIRVHMREANHPLA 270

Query: 177 GDRFYASPEA----------RAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           GD  Y +P            +++  R  LHA  L+ THP  G +++F+AP  
Sbjct: 271 GDPVYGNPRHPCGDTVKEAVKSLGARQALHAYRLSFTHPESGETVSFEAPIP 322


>UniRef50_Q45826 Uncharacterized RNA pseudouridine synthase Caur_0901 n=5
           Tax=Chloroflexi (class) RepID=Y901_CHLAA
          Length = 316

 Score =  324 bits (831), Expect = 2e-87,   Method: Composition-based stats.
 Identities = 72/216 (33%), Positives = 107/216 (49%), Gaps = 10/216 (4%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRD-------YPQAESVHR 62
           +   L ++Y+D  I V+NKP+G++  P         V   + R          +   VHR
Sbjct: 87  EPIPLDVVYEDADIAVINKPAGMVVHPAPGHPRGTLVNALLARYPDLAIGGELRPGIVHR 146

Query: 63  LDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNR 122
           LD  TSG++V+A    A R L  Q + R  +K Y A V G P P  G +D P+  D  +R
Sbjct: 147 LDRDTSGLLVIARHDQAMRSLVDQQQARRMRKIYQALVIGRP-PETGTIDAPIGRDPRDR 205

Query: 123 PKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYA 182
            +  V    G+PA+T Y +++   D  + + ++  TGR+HQ+RVH+  LG+PI+GD  Y 
Sbjct: 206 LRMAVV-PDGRPARTHYRLLDTFGD-YSLLEVQLETGRTHQIRVHLRHLGYPIVGDPVYG 263

Query: 183 SPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
              +     R  LHA  L + HP  G    F AP  
Sbjct: 264 PRRSHLHLSRQFLHAAYLGLVHPRSGRWQEFTAPLP 299


>UniRef50_C7NAV5 Pseudouridine synthase n=5 Tax=Fusobacteriaceae RepID=C7NAV5_LEPBD
          Length = 326

 Score =  323 bits (830), Expect = 2e-87,   Method: Composition-based stats.
 Identities = 69/225 (30%), Positives = 107/225 (47%), Gaps = 16/225 (7%)

Query: 7   NPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYPQAE 58
             P+   + I+Y+D+ + V+NK +G++  P         V   +             +  
Sbjct: 92  IKPENIDIEIIYEDNDLAVINKKAGIVVHPANGHYSGTLVNAILYHIKDLSGINGEIRPG 151

Query: 59  SVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICD 118
            VHRLD  TSG++++A    A  +L + F ++  KK Y+A + G  +   G +   +  D
Sbjct: 152 IVHRLDKDTSGLLIIAKNDKAHLKLSQMFHDKTVKKIYLAILKGKLNQKSGRIVTQIGRD 211

Query: 119 WPNRPKQKVCYE--TGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPIL 176
             +R K  V  +  +GK A T YEV+    +    V +   TGR+HQ+RVHM  LG+PIL
Sbjct: 212 KNDRKKMTVINDLNSGKTAITNYEVISQ-TEKFTLVKVHIETGRTHQIRVHMKHLGYPIL 270

Query: 177 GDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
           GD  Y   +      R +LHA  L   HP    ++ F A  P DF
Sbjct: 271 GDSVYGRTDTE---KRQMLHAYKLEFQHPITEENLEFIAKLPEDF 312


>UniRef50_C6XFD0 Pseudouridine synthase n=1 Tax=Candidatus Liberibacter asiaticus
           str. psy62 RepID=C6XFD0_LIBAP
          Length = 340

 Score =  323 bits (830), Expect = 2e-87,   Method: Composition-based stats.
 Identities = 75/242 (30%), Positives = 107/242 (44%), Gaps = 33/242 (13%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR---------DYPQAESV 60
           +   L ILY+DD I+V+NKP+GL+  P         V   +              +   V
Sbjct: 86  ENIPLDILYEDDDIIVINKPAGLVVHPAPGNWTGTLVNALLYHCHNNLSSINGVKRPGIV 145

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFRER----EPKKQYVARVWGHPSPAEGLVDLPLI 116
           HRLD  T+GV+VVA    A ++L  QF +       K+ Y A VWG P P  G+++ PL 
Sbjct: 146 HRLDKDTTGVMVVAKNDLAHQKLSEQFVDHGKSTRLKRAYYAMVWGIPLPDSGIINAPLG 205

Query: 117 CDWPNRPKQKV---CYETGKPAQTEYEVVEYAADN----TARVVLKPITGRSHQLRVHML 169
               NR ++ V     +T   A T Y+ +E    N     + +     TGR+HQ+RVHM 
Sbjct: 206 RCKSNRLRRAVKGIDDKTADSAITHYQTIEIYNKNSNFAVSLLKCHLETGRTHQIRVHMA 265

Query: 170 ALGHPILGDRFYAS-------------PEARAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
             G+P++GD  Y                 A     R  LHA  L+ +HP     M F+ P
Sbjct: 266 HKGNPLIGDPLYGKGFKTKANIVNNNAKSAILSLARQALHAHSLSFSHPRNNQDMDFQVP 325

Query: 217 AD 218
             
Sbjct: 326 IP 327


>UniRef50_Q82WZ5 Ribosomal large subunit pseudouridine synthase D n=2
           Tax=Nitrosomonas RepID=RLUD_NITEU
          Length = 344

 Score =  322 bits (828), Expect = 4e-87,   Method: Composition-based stats.
 Identities = 77/229 (33%), Positives = 122/229 (53%), Gaps = 15/229 (6%)

Query: 2   GMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR-----DYPQ 56
             +  +  +   L IL++DDH+++++KP+GL+  PG    H   +   +         P+
Sbjct: 97  ENDQSHQAEAIPLKILFEDDHLIIIDKPAGLVVHPGNGNWHGTLLNALLNHAPQLSQVPR 156

Query: 57  AESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLI 116
           A  VHRLD  T+G++VVA T  A+ +L RQ ++R  K+ Y+A V G      G+VD P+ 
Sbjct: 157 AGIVHRLDKDTTGLLVVAKTIEAQFDLARQLQQRTVKRHYLALVLGKLEKD-GVVDAPIG 215

Query: 117 CDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPIL 176
               +R +  V  + GKPA+T Y V+E    +   +     TGR+HQ+RVH+L++GHP+ 
Sbjct: 216 RHPIHRTRMAVV-QNGKPARTHYRVLEKFTAS-TLLHCSLETGRTHQIRVHLLSIGHPLA 273

Query: 177 GDRFYAS-------PEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           GD  Y          +A    PR  LHA  L +THP  G  + +++P  
Sbjct: 274 GDPVYGRTSPDPSTADAVVRLPRQALHAWQLELTHPHSGQILLWESPLP 322


>UniRef50_B1I3F8 Pseudouridine synthase n=2 Tax=Bacteria RepID=B1I3F8_DESAP
          Length = 309

 Score =  322 bits (826), Expect = 6e-87,   Method: Composition-based stats.
 Identities = 71/220 (32%), Positives = 102/220 (46%), Gaps = 9/220 (4%)

Query: 7   NPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYPQAE 58
             P+   L + ++D  ++VVNKP GL+  P         V   +             +  
Sbjct: 74  IEPEAIPLEVCFEDPDVLVVNKPRGLVVHPAVGHYSGTLVNALLHHCRDLSGINGILRPG 133

Query: 59  SVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICD 118
            VHRLD  TSG+++VA   AA   L  Q ++R   ++Y A V G P    G VD P+   
Sbjct: 134 IVHRLDRDTSGLLMVAKNDAAHLALAGQLKDRAVLRRYTALVHGRPRRETGTVDAPIGRH 193

Query: 119 WPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGD 178
             +R +  V   +G+ A+T Y VV    D  + + L   TGR+HQ+RVHM  +GHP++GD
Sbjct: 194 PRDRQRMAVTPRSGRAARTHYRVVRRF-DKFSLLELTLDTGRTHQIRVHMAHVGHPLVGD 252

Query: 179 RFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
             Y             LHA  L   HP  G  + F+AP  
Sbjct: 253 LKYGHARPELGLEGQFLHAGTLGFRHPRTGEVLVFEAPLP 292


>UniRef50_C8QZ10 Pseudouridine synthase n=1 Tax=Desulfurivibrio alkaliphilus AHT2
           RepID=C8QZ10_9DELT
          Length = 324

 Score =  322 bits (826), Expect = 8e-87,   Method: Composition-based stats.
 Identities = 77/219 (35%), Positives = 102/219 (46%), Gaps = 11/219 (5%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYPQAESVH 61
           +E     LY+D+ I+V+ KP GL+  P         V   +             +   VH
Sbjct: 89  EEVEFTPLYEDEDILVLVKPPGLVVHPADGHRQGTLVHGLLHHCRNLSGISGQLRPGIVH 148

Query: 62  RLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPN 121
           RLD  TSG +VVA    A   L +QF+ RE +K Y A + G  +   G V LP+     +
Sbjct: 149 RLDKDTSGCLVVAKNDLAHHNLVQQFKGREVEKTYQALLRGILAEDTGQVVLPIGRHPVH 208

Query: 122 RPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFY 181
           R K  V  E G+ A T + V +  +     V L   TGR+HQ+RVHM ALGHP+ GDR Y
Sbjct: 209 RKKMAVRREGGREAVTHWRVRQRFSAGYTLVELLLETGRTHQIRVHMAALGHPLAGDRLY 268

Query: 182 ASPEAR---AMAPRLLLHAEMLTITHPAYGNSMTFKAPA 217
                +       R  LHA  L   HP  G  +TF AP 
Sbjct: 269 GRNPEKDMPYGIDRQWLHAWRLAFNHPRSGRRLTFTAPL 307


>UniRef50_Q6AJM1 Pseudouridine synthase n=1 Tax=Desulfotalea psychrophila
           RepID=Q6AJM1_DESPS
          Length = 327

 Score =  321 bits (824), Expect = 1e-86,   Method: Composition-based stats.
 Identities = 78/227 (34%), Positives = 112/227 (49%), Gaps = 13/227 (5%)

Query: 6   YNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYPQA 57
              PQ+     +Y+DD ++V++KP G++  PG        V   +          D  + 
Sbjct: 87  SLEPQQVDFESIYEDDSLLVLSKPPGIVVHPGNGNTEGTLVHGLLYHCREIGGVGDAIRP 146

Query: 58  ESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLIC 117
             VHRLD  TSG +VVA  + + R L   F+ER+  K Y A V G P   EG +  P+  
Sbjct: 147 GIVHRLDKDTSGAMVVAKDERSLRTLVDSFKERQVYKVYHALVCGIPKKYEGRIVAPIGR 206

Query: 118 DWPNRPKQKVCYETGKPAQTEYEVVEYAADN---TARVVLKPITGRSHQLRVHMLALGHP 174
              +R K  +   TGK A T ++VVE         + + +   TGR+HQ+RVHM ++G P
Sbjct: 207 HSVHRQKMAISERTGKFAATNWQVVEVFETKDGPYSLLRVHIETGRTHQIRVHMSSIGCP 266

Query: 175 ILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPA--DF 219
           I GD+ Y S        R +LHA  L + HP  G +M+F AP   DF
Sbjct: 267 IAGDQVYGSKRQNPAFARQMLHASRLRLPHPVTGRTMSFTAPLWQDF 313


>UniRef50_B6AN83 Pseudouridine synthase n=2 Tax=Leptospirillum RepID=B6AN83_9BACT
          Length = 340

 Score =  320 bits (823), Expect = 2e-86,   Method: Composition-based stats.
 Identities = 76/232 (32%), Positives = 111/232 (47%), Gaps = 22/232 (9%)

Query: 8   PPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------------- 52
            P++  L ILY+DD ++V++KP GL+  P         V   +                 
Sbjct: 89  QPEDIHLEILYEDDDLIVISKPPGLVVHPAPGHASGTLVNGLLFHFQSQGDEQKKGEPEE 148

Query: 53  -----DYPQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPA 107
                   +A  VHRLD  TSGV+VV  ++    +L  QF++R   K+Y+A V G     
Sbjct: 149 EEEAERPLRAGLVHRLDQDTSGVMVVGKSETVVLDLMNQFKDRSVSKKYLALVKGILPKK 208

Query: 108 EGLVDLPLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVH 167
            G ++ P+     +R K  V  + GKP+ T Y V+E   +N + + +  +TGR+HQ+RVH
Sbjct: 209 RGEINAPIGRSTHDRKKFAV-RQDGKPSLTRYRVLETYHENYSLLEVTLLTGRTHQIRVH 267

Query: 168 MLALGHPILGDRFYASPE-ARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
              LG P+LGD  Y S        PR +LHA  L   HP     M F+AP  
Sbjct: 268 FRHLGFPLLGDAVYGSKGMENRNFPRQMLHAWKLAFQHPRSAAKMEFEAPLP 319


>UniRef50_C8NEP8 Pseudouridine synthase n=1 Tax=Granulicatella adiacens ATCC 49175
           RepID=C8NEP8_9LACT
          Length = 308

 Score =  320 bits (821), Expect = 3e-86,   Method: Composition-based stats.
 Identities = 71/222 (31%), Positives = 111/222 (50%), Gaps = 12/222 (5%)

Query: 7   NPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR----------DYPQ 56
             P+   L I+++DD ++VVNKPSG++  P +       V   +            +  +
Sbjct: 73  IQPENIPLDIVFEDDSLIVVNKPSGMVVHPSKGHYSGTLVNALLYHSNSLSDSTSEEIYR 132

Query: 57  AESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLI 116
              VHR+D  TSG++V+A      ++L  Q  E +  ++Y+A V GH +   G+VD PL 
Sbjct: 133 PGLVHRIDKDTSGLLVIAKNNDVHQKLAEQIAENKMNREYIAIVDGHFAHETGVVDAPLS 192

Query: 117 CDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPIL 176
               NR K+ V  + GK A T +EV++  +D  + V  +  TGR+HQ+R HM  + HPI+
Sbjct: 193 RHQTNRLKR-VVEKGGKNAITHFEVLDSFSD-YSLVSCRLETGRTHQIRAHMEFIKHPIV 250

Query: 177 GDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
            D  Y      A      LHA  L+ THP  G ++ F+    
Sbjct: 251 NDPLYHPKGKNATEFGQFLHARTLSFTHPLTGETLNFQVEPP 292


>UniRef50_B9L028 Pseudouridine synthase n=2 Tax=Thermomicrobia (class)
           RepID=B9L028_THERP
          Length = 322

 Score =  318 bits (816), Expect = 9e-86,   Method: Composition-based stats.
 Identities = 75/226 (33%), Positives = 109/226 (48%), Gaps = 10/226 (4%)

Query: 1   MGMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTR--IQRDYP--- 55
           +       P+   + ++Y+DD I+V +KP G+++ P    EH   V     I+ D     
Sbjct: 75  VEPPTDLEPEFLPIPVIYEDDDIIVFDKPPGIVTHPAPGHEHGTLVNALKAIRPDLQVQP 134

Query: 56  --QAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDL 113
             +   VHRLD  TSG++VVA T+AA   L  Q++ R   K+Y A V G   P  G +D 
Sbjct: 135 SHRPGIVHRLDKDTSGLLVVAKTEAARLALLEQWQSRSVVKKYTALVHGVVEPDSGTIDA 194

Query: 114 PLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGH 173
           P+  D   R K  V    G+PA T + V+E        + +   TGR+HQ+RVH   +GH
Sbjct: 195 PISRDPVERTKMAVVS-WGRPAITHFRVLERFRC-ATLLDVTIETGRTHQIRVHCAFIGH 252

Query: 174 PILGDRFYAS-PEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           P++GD  Y          PR  LHA  L   HP  G ++  + P  
Sbjct: 253 PVVGDSQYGGHRPFCVPVPRQFLHARYLRFVHPTTGQAIELETPLP 298


>UniRef50_Q2W2D5 Pseudouridine synthase n=39 Tax=Bacteria RepID=Q2W2D5_MAGSA
          Length = 505

 Score =  317 bits (814), Expect = 2e-85,   Method: Composition-based stats.
 Identities = 76/236 (32%), Positives = 115/236 (48%), Gaps = 25/236 (10%)

Query: 8   PPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR---------DYPQAE 58
            PQ+  L ++Y+D+ ++V++KP+G++  P      +  V   +              +  
Sbjct: 259 EPQDIALTVVYEDEDLIVIDKPAGMVVHPAPGNPDETLVNALLAHCGESLAGIGGVKRPG 318

Query: 59  SVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICD 118
            VHR+D  TSG++V A T AA R L  QF     ++ Y A VWG PSP +G ++  +  +
Sbjct: 319 IVHRIDKDTSGLLVAAKTDAAHRGLATQFAAHTLERAYWALVWGTPSPRQGEIEGNIGRN 378

Query: 119 WPNRPKQKVCYETGKPAQTEYEVVEYAADNT-ARVVLKPITGRSHQLRVHMLALGHPILG 177
             +R K  V    GKPA T Y V++  A    + V  +  TGR+HQ+RVHM   GHP++G
Sbjct: 379 PNDRKKMAVVKSGGKPALTRYRVLKSFAGGAVSLVECRLATGRTHQIRVHMTTQGHPLVG 438

Query: 178 DRFYAS-------------PEARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PAD 218
           D  Y                 A    PR  LHA +L  +HP  G  + F++  P D
Sbjct: 439 DPVYGRIRGHKGVVLPPEVKTALIQFPRQALHAYLLGFSHPTKGYDVRFESGMPLD 494


>UniRef50_A7HM17 Pseudouridine synthase n=2 Tax=Thermotogaceae RepID=A7HM17_FERNB
          Length = 314

 Score =  317 bits (813), Expect = 3e-85,   Method: Composition-based stats.
 Identities = 79/224 (35%), Positives = 113/224 (50%), Gaps = 13/224 (5%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYPQAESV 60
           P++  L I+Y+D  I+V+NK  G+++ P         V   +             +   V
Sbjct: 74  PEDIPLDIIYEDRDILVINKQPGIITHPIPSHTSGTIVNGVLYHCKDLQGIGGVLRPGIV 133

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLD  TSGV+V+A    A + L +QF++R  +K Y+  V G P   EG +++ +  +  
Sbjct: 134 HRLDKDTSGVMVIAKNDLAHQSLTKQFKDRLTEKLYICLVKGVPKRKEGDIEINIARNPV 193

Query: 121 NRPKQKV-CYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDR 179
            R K  V   E GKPA T Y+VV    D  A V   P TGR+HQ+RVHM  +GHP++GD 
Sbjct: 194 LRVKMTVTNSEYGKPALTHYKVVREFGDIAALVFAYPKTGRTHQIRVHMKYIGHPLMGDE 253

Query: 180 FYASPEARA--MAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
            Y   +        R +LHA  L+  HP  G  + F A  P DF
Sbjct: 254 VYGRAKEDEIFGIKRQMLHALSLSFYHPRTGEKVKFIAKIPQDF 297


>UniRef50_B2A2J2 Pseudouridine synthase n=1 Tax=Natranaerobius thermophilus
           JW/NM-WN-LF RepID=B2A2J2_NATTJ
          Length = 328

 Score =  315 bits (810), Expect = 5e-85,   Method: Composition-based stats.
 Identities = 72/233 (30%), Positives = 109/233 (46%), Gaps = 16/233 (6%)

Query: 1   MGMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR-------- 52
           +  E    PQ   L I+Y+D++++VVNKP  ++  PG        V   +          
Sbjct: 78  IQSEITLIPQSIPLDIVYEDEYLLVVNKPRNMVVHPGAGNYRDTMVNALLYHCQNLSDGT 137

Query: 53  DYPQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVD 112
            Y +   VHRLD  TSG++VVA        L  + + R   + Y+A V G  S  +  +D
Sbjct: 138 SYERPGIVHRLDKDTSGLLVVAKQNETHDILSEEIKNRRVARTYLALVIGDFSKKKATID 197

Query: 113 LPLICDWPNRPKQKVCYETGKPAQTEYEVVEYA--ADNTARVVLKPITGRSHQLRVHMLA 170
           LP+  D  NR K  V +  GK A T+ E++      +  + +     TGR+HQ+RVH+  
Sbjct: 198 LPIGRDPRNRKKMAVVH-GGKRAITKVEMLRSFQNPEKISYLKCSLETGRTHQIRVHLSH 256

Query: 171 LGHPILGDRFYASPEAR-----AMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           LG+P+LGD  Y     +            LH+  L  THP +  +M F+AP  
Sbjct: 257 LGYPLLGDPVYRGKTGKNVDIDKNLTGQALHSFSLAFTHPVFKKTMVFRAPLP 309


>UniRef50_P50513 Ribosomal large subunit pseudouridine synthase D n=8
           Tax=Sphingomonadales RepID=RLUD_ZYMMO
          Length = 317

 Score =  315 bits (809), Expect = 6e-85,   Method: Composition-based stats.
 Identities = 76/230 (33%), Positives = 110/230 (47%), Gaps = 19/230 (8%)

Query: 6   YNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR---------DYPQ 56
           +N PQ+  L I+++D+H++VVNKP+G++  P         V   +              +
Sbjct: 74  HNEPQDIPLEIVFEDEHLLVVNKPAGMVVHPAAGNYDNTLVNALLYHCAGKLSGIGGVAR 133

Query: 57  AESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLI 116
              VHR+D  TSG++VVA T  A   L  QF +    ++Y A V GHPS  +G VD PL 
Sbjct: 134 PGIVHRIDKDTSGLLVVAKTDPAHAGLAAQFADHSINRRYRAIVDGHPS-LQGHVDAPLA 192

Query: 117 CDWPNRPKQKVCYET-GKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPI 175
               NR K  +  +  GK A T Y ++     N + +  +  TGR+HQ+RVHM ++GH +
Sbjct: 193 RSSVNRQKMAIVSDGRGKRAVTHYRMI-TPLKNASLIECRLETGRTHQVRVHMSSIGHSL 251

Query: 176 LGDRFYASPE-------ARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           LGD  Y   +             R  LHA  L   HP  G  + F A   
Sbjct: 252 LGDPVYGRSKKAHHALLQSLAFQRQALHAAHLGFIHPISGKQVDFDAEMP 301


>UniRef50_C4FWV7 Pseudouridine synthase n=2 Tax=Firmicutes RepID=C4FWV7_9FIRM
          Length = 309

 Score =  315 bits (809), Expect = 7e-85,   Method: Composition-based stats.
 Identities = 75/233 (32%), Positives = 117/233 (50%), Gaps = 17/233 (7%)

Query: 1   MGMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR-------- 52
           +  ++   P+   L I+Y+D+ I+V+NKP+GL+  P +       V   +          
Sbjct: 68  VEEDSLPEPEAMDLDIIYEDEDILVINKPAGLVVHPSKGHLKGTLVNGLLHYLNGNLSTG 127

Query: 53  -DYPQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLV 111
            D+ +   VHR+D  TSG++VVA   AA + L  Q    + ++ Y+A V G     +G +
Sbjct: 128 SDFYRPGIVHRIDKDTSGLLVVAKHNAAHQALADQLLNHDMRRSYIALVHGQVKAPQGTI 187

Query: 112 DLPLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLAL 171
           + PL  D  NR +  V  E GK A T ++V+E   +N   + L+  TGR+HQ+RVH+  +
Sbjct: 188 EAPLQRDPANRLRWTVAKE-GKYALTRFQVMENF-ENATLLDLELETGRTHQIRVHLEFI 245

Query: 172 GHPILGDRFY--ASPEARAMA----PRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           GHP++GD  Y       +          LLHA  L + HP  G  + FKAP  
Sbjct: 246 GHPLVGDPVYRKGLDHIKGSLVHDMTGQLLHAYALKLQHPRSGEWLEFKAPLP 298


>UniRef50_C9LM35 Pseudouridine synthase n=1 Tax=Dialister invisus DSM 15470
           RepID=C9LM35_9FIRM
          Length = 308

 Score =  314 bits (805), Expect = 2e-84,   Method: Composition-based stats.
 Identities = 70/218 (32%), Positives = 108/218 (49%), Gaps = 10/218 (4%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR---------DYPQAESV 60
           Q   L ILY+D+ ++V+NK  G++  PG        V   +           D  +   V
Sbjct: 76  QNIPLDILYEDNDMIVINKRRGVVVHPGAGNTEGTLVNALLFHCGEQLRSVGDPERPGIV 135

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLD  TSGV+V A ++ A   L+++    + ++ Y+A V G      G++ LPL     
Sbjct: 136 HRLDKDTSGVMVAAKSERAYGILQKEIASHKAQRCYIALVHGQMEGDTGVIRLPLGRSTK 195

Query: 121 NRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRF 180
           +R K  V +ETG+PA T + V+EY   + + +  K  TGR+HQ+RVHM  + H ++ D  
Sbjct: 196 DRMKWDVLHETGRPAVTHFHVIEYLP-HYSWIECKLETGRTHQIRVHMAHIRHAVVNDPL 254

Query: 181 YASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           Y   +         LH+  L + HP  G  M F+AP  
Sbjct: 255 YGWKKDHFPIKGQALHSHTLELCHPITGEVMHFEAPVP 292


>UniRef50_C0BNA6 Pseudouridine synthase n=7 Tax=Bacteroidetes RepID=C0BNA6_9BACT
          Length = 379

 Score =  312 bits (802), Expect = 4e-84,   Method: Composition-based stats.
 Identities = 73/240 (30%), Positives = 107/240 (44%), Gaps = 26/240 (10%)

Query: 4   ENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR-------DYPQ 56
           E    P++  L ++Y+D  +MVVNKP G++  PG        +   +            +
Sbjct: 122 EFLLTPEDIPLDVVYEDSDLMVVNKPPGMVVHPGHGNYSGTLINALLFHVKDLPLNADER 181

Query: 57  AESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLI 116
              VHR+D  TSG++VVA T  A   L +QF ++  +++YVA VWG+    +G V   + 
Sbjct: 182 PGLVHRIDKDTSGLLVVAKTAKAMTHLAKQFFDKTSEREYVAIVWGNVEEEQGTVRGHIG 241

Query: 117 CDWPNRPKQKV--CYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHP 174
               NR +  V    + GK A T Y+V+E        V     TGR+HQ+R HM  +GH 
Sbjct: 242 RHPKNRLQMAVFPDGDQGKEAVTHYKVMERLG-YVTLVSCVLETGRTHQIRAHMKHIGHT 300

Query: 175 ILGDRFYASPE----------------ARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           +  D  Y   +                A    PR  LHA+ L   HP+ G  M F  P  
Sbjct: 301 LFNDERYGGEKILKGTTFTKYKQFVDNAFKALPRQALHAKTLGFVHPSSGELMRFNTPIP 360


>UniRef50_B8E0R4 Pseudouridine synthase n=1 Tax=Dictyoglomus turgidum DSM 6724
           RepID=B8E0R4_DICTD
          Length = 303

 Score =  312 bits (800), Expect = 7e-84,   Method: Composition-based stats.
 Identities = 61/224 (27%), Positives = 106/224 (47%), Gaps = 10/224 (4%)

Query: 3   MENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DY 54
           +E    PQ+  + I+Y+D+ ++++NKP G++  P     +   V   + R          
Sbjct: 68  VETEVKPQDIPIEIVYEDEDMVIINKPKGMVVHPAHGHYNDTLVNALLYRVKDLSGIGGE 127

Query: 55  PQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLP 114
            +   +HRLD  T+G++++A    + ++L  Q + R  ++ Y A   G     E  ++ P
Sbjct: 128 LRPGIIHRLDKDTTGLLIIAKNDLSHQKLSEQLKNRTLRRTYWALCEGEIPWEEKRIEAP 187

Query: 115 LICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHP 174
           +     NR K  +    GK A T ++V+E        +     TGR+HQ+RVH+  LG P
Sbjct: 188 IGRHPINRKKMAIV-PYGKIAITNFKVLERFK-GYTLISADLETGRTHQIRVHISHLGFP 245

Query: 175 ILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           I+GD  Y   + +      LLHA+ ++  HP  G  M F+    
Sbjct: 246 IVGDEVYGRIDKKFGVKGQLLHAKKVSFIHPTKGIPMEFEIDLP 289


>UniRef50_A9IQ66 Pseudouridine synthase n=5 Tax=Bacteria RepID=A9IQ66_BART1
          Length = 334

 Score =  312 bits (800), Expect = 7e-84,   Method: Composition-based stats.
 Identities = 76/244 (31%), Positives = 109/244 (44%), Gaps = 35/244 (14%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR---------DYPQAESV 60
           +   L ILY+DDH++V+NKP+GL+  PG        V   I              +   V
Sbjct: 77  EAIALDILYEDDHVIVINKPAGLVVHPGNGNWTGTLVNALIYHCGNSLSGIGGVKRPGVV 136

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFRER----EPKKQYVARVWGHPSPAEGLVDLPLI 116
           HRLD  TSGV+VVA    A + L  QF +        ++Y A +WG P      +D  L 
Sbjct: 137 HRLDKNTSGVMVVAKNDLAHKSLSAQFSDHGRTCALDRRYHALIWGTPHRNVWTIDASLG 196

Query: 117 CDWPNRPKQKVCY---ETGKPAQTEYEVVEYAADNT------ARVVLKPITGRSHQLRVH 167
               NR KQ V +      + A T + ++E    +       + +  +  TGR+HQ+RVH
Sbjct: 197 RSPHNRTKQAVVHKQTPHARHAVTHFSLLEKYGTHADSTSFASLLECRLETGRTHQIRVH 256

Query: 168 MLALGHPILGDRFYAS-------------PEARAMAPRLLLHAEMLTITHPAYGNSMTFK 214
           M  +GHP++GD  Y +               A     R  LHA  LT  HP+ G  ++F 
Sbjct: 257 MAHIGHPLIGDTVYGNAFKTKSNTLNPTLKNAIDQFNRHALHAASLTFEHPSSGKVISFS 316

Query: 215 APAD 218
           AP  
Sbjct: 317 APLP 320


>UniRef50_B9JRD0 Pseudouridine synthase n=1 Tax=Agrobacterium vitis S4
           RepID=B9JRD0_AGRVS
          Length = 342

 Score =  311 bits (799), Expect = 8e-84,   Method: Composition-based stats.
 Identities = 76/254 (29%), Positives = 109/254 (42%), Gaps = 36/254 (14%)

Query: 1   MGMENYNPP--QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR------ 52
           M       P  ++  L +LY+D  ++V++KP+GL+  PG        V   I        
Sbjct: 75  MPEPEDPEPKGEDIPLTVLYEDKDLIVLSKPAGLVVHPGAGNWTGTLVNALIHHCGDSLS 134

Query: 53  ---DYPQAESVHRLDMATSGVIVVALTKAAERELKRQFRERE----PKKQYVARVWGHPS 105
                 +   VHRLD  TSGV+VVA    A R L  QF +       ++ Y A VWG P 
Sbjct: 135 GIGGVKRPGIVHRLDKETSGVMVVAKNDIAHRHLADQFADHGRSGPLERAYQALVWGRPR 194

Query: 106 PAEGLVDLPLIC--DWPNRPKQKVCYETGKPAQTEYEVVEYAADN------TARVVLKPI 157
              G +D  L    D   R  ++   +  + A T Y+V+E   +        + V  +  
Sbjct: 195 GLRGTIDAALGRAGDRTKRTVKREDTDDAREAITHYQVMERYGEKPDATCLASLVECRLE 254

Query: 158 TGRSHQLRVHMLALGHPILGDRFYA-------------SPEARAMAPRLLLHAEMLTITH 204
           TGR+HQ+RVHM  +GHP++GD  Y              +        R  LHA +L   H
Sbjct: 255 TGRTHQIRVHMAHIGHPLIGDPEYGAAFKTKANLLPDAAKAIVTNFHRQALHAYLLAFEH 314

Query: 205 PAYGNSMTFKAPAD 218
           P  G+ M F AP  
Sbjct: 315 PTTGDVMHFAAPIP 328


>UniRef50_Q3A0C2 Pseudouridine synthase n=13 Tax=Bacteria RepID=Q3A0C2_PELCD
          Length = 326

 Score =  311 bits (799), Expect = 1e-83,   Method: Composition-based stats.
 Identities = 68/230 (29%), Positives = 100/230 (43%), Gaps = 21/230 (9%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYPQAESVH 61
           ++  LVILY+D H++V++KP G++  P         V   +             +   VH
Sbjct: 77  EDIPLVILYEDRHLIVIDKPPGMVVHPAPGHYQGTLVNALLHHCQDLSGIGGELRPGIVH 136

Query: 62  RLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPN 121
           RLD  TSGV+V   T +A + L  QF+     ++Y+A + G  +   G +D P+     +
Sbjct: 137 RLDKDTSGVMVATKTDSAHQSLAAQFKAHSITRRYIALIHGVLTGDRGSIDRPIGRHPTH 196

Query: 122 RPKQKVCYETGKPAQTEYEVVEYA-ADNTARVVLKPITGRSHQLRVHMLALGHPILGDRF 180
           R K      TG+ A T + V+     D    V L   TGR+HQ+RVH     HP+LGD  
Sbjct: 197 RKKMSTTCRTGRHAVTHWRVLRRFDDDRLTLVELALETGRTHQIRVHFSEQQHPLLGDPV 256

Query: 181 YASPEARAMAP------------RLLLHAEMLTITHPAYGNSMTFKAPAD 218
           Y                      R  LHA +L   HP  G  + F +P  
Sbjct: 257 YGGSGRLKTINDPQLLKRAKALGRQALHARLLGFQHPETGKYLEFSSPLP 306


>UniRef50_A3M2Y1 Pseudouridine synthase n=18 Tax=Gammaproteobacteria
           RepID=A3M2Y1_ACIBT
          Length = 350

 Score =  311 bits (798), Expect = 1e-83,   Method: Composition-based stats.
 Identities = 70/235 (29%), Positives = 109/235 (46%), Gaps = 20/235 (8%)

Query: 1   MGMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR-----DYP 55
           +  +  + P+   L I+Y+D+ I+V+NKP G++  PG        V   +       +  
Sbjct: 102 LEAQTNSQPENIPLDIVYEDEDILVINKPVGMVVHPGAGNTSSTLVNALLYHSPKSAELS 161

Query: 56  QAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPL 115
           +A  VHR+D  TSG++VVA    A+  L +Q  ++   + Y    +G+     G +D P+
Sbjct: 162 RAGLVHRIDKDTSGLLVVAKNLEAQFSLSKQLGDKSVYRIYDLVTYGNIIAG-GTIDEPI 220

Query: 116 ICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPI 175
                +R K  +    G+ A T Y V E   D   RV  +  TGR+HQ+RVH   +GH +
Sbjct: 221 KRHPVDRVKMAIL-PGGRDAVTHYNVKERFRD-FTRVQAQLETGRTHQIRVHFSYIGHGL 278

Query: 176 LGDRFYASP------------EARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           +GD+ Y +             E      R  LHA  L + HP  G  M F+AP  
Sbjct: 279 VGDQVYMNRVRIPAGASELLIETLRGFKRQALHAAKLGLKHPRTGEEMLFEAPWP 333


>UniRef50_Q2SS88 Pseudouridine synthase n=4 Tax=Mollicutes RepID=Q2SS88_MYCCT
          Length = 322

 Score =  311 bits (798), Expect = 1e-83,   Method: Composition-based stats.
 Identities = 65/224 (29%), Positives = 100/224 (44%), Gaps = 9/224 (4%)

Query: 3   MENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP------- 55
             N    ++  L I+YQDD ++V+NK + +   P     +   V   +  D         
Sbjct: 84  DPNITKNKDIDLNIIYQDDDLLVINKQNNITVHPSLNNTNNTIVNALLASDVELSSINGE 143

Query: 56  -QAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLP 114
            +   VHR+D  T+G+++VA      + L   F+  +  K+Y+A V G   P +GL+D P
Sbjct: 144 LRPGIVHRIDKQTTGLLIVAKNDKTHKLLSEMFKNHQIYKEYLAIVTGVIKPNKGLIDAP 203

Query: 115 LICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHP 174
           +     +R K  V  +  K A T +EVVE    N   +  +  TGR+HQ+RVH   + HP
Sbjct: 204 IGRSQTDRKKMSVTAKNSKHAITTFEVVERFLKN-TLIKCQIQTGRTHQIRVHFNYINHP 262

Query: 175 ILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           +L D  Y             LHA  L  THP     +   +P  
Sbjct: 263 VLNDPIYGKKHQEFTDFGQYLHAYKLKFTHPITKKEIELISPLP 306


>UniRef50_Q2LWV4 Pseudouridine synthase n=1 Tax=Syntrophus aciditrophicus SB
           RepID=Q2LWV4_SYNAS
          Length = 333

 Score =  311 bits (798), Expect = 1e-83,   Method: Composition-based stats.
 Identities = 75/232 (32%), Positives = 107/232 (46%), Gaps = 21/232 (9%)

Query: 7   NPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYPQAE 58
             PQ+  L ILY+D  ++V++KP+GL+  P         V   +             +  
Sbjct: 78  LIPQDIPLSILYEDHDLLVLDKPAGLVVHPAAGHVSGTLVNALLFHCRDLAGIGGVMRPG 137

Query: 59  SVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICD 118
            VHRLD  TSG++VVA T AA + L  QF++ +  K Y A V+G P    G +DLP+   
Sbjct: 138 IVHRLDKDTSGLLVVAKTDAAHQGLALQFKKHQVGKTYQALVYGDPREKTGQIDLPVGRH 197

Query: 119 WPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGD 178
              R K       GK A T + + E        + +  +TGR+HQ+RVH+ A+GHP++GD
Sbjct: 198 PVERKKMSTKSRRGKEAATRWRIAERFGV-ATLLNVDIVTGRTHQIRVHLAAIGHPVVGD 256

Query: 179 RFYAS------------PEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
             Y S                    R  LHA  L+ THP     + F AP  
Sbjct: 257 AVYGSSKRATTLTDPAVKGRLKEMSRQALHAARLSFTHPVTHKILEFHAPLP 308


>UniRef50_A5WFS2 Pseudouridine synthase n=3 Tax=Psychrobacter RepID=A5WFS2_PSYWF
          Length = 420

 Score =  310 bits (797), Expect = 1e-83,   Method: Composition-based stats.
 Identities = 72/237 (30%), Positives = 112/237 (47%), Gaps = 20/237 (8%)

Query: 1   MGMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRD-----YP 55
           +     + P++  L I+Y+DD ++V+NKP G++  PG        V   +         P
Sbjct: 168 LEQHGSDQPEDIKLDIIYEDDSVIVINKPVGMVVHPGAGNWSGTLVNGLLYHYPNQAHLP 227

Query: 56  QAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPS--PAEGLVDL 113
           +A  VHR+D  TSG++V+  TKAA+ EL+ Q +++   + Y   V G       +  +D 
Sbjct: 228 RAGLVHRIDKNTSGLLVIGKTKAAQLELQEQLKDKSVYRHYQCVVAGDAPSLARQRTIDA 287

Query: 114 PLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGH 173
           P+      R K  V   TGK A T    +   +D  + + ++  TGR+HQ+RVH+  +GH
Sbjct: 288 PIGRHRTQRTKMTV-TSTGKTAITHIMKITPLSDTYSLLDVRLETGRTHQIRVHLSHIGH 346

Query: 174 PILGDRFYASPEARAM------------APRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           PI+GD  Y + +                 PR  LHA  L   HP  G S+   AP  
Sbjct: 347 PIIGDDIYGNRQQLRAGLTPEQRQAIQSFPRQALHAYKLGFIHPETGESIELTAPLP 403


>UniRef50_B8FLB4 Pseudouridine synthase n=2 Tax=Bacteria RepID=B8FLB4_DESAA
          Length = 321

 Score =  310 bits (797), Expect = 2e-83,   Method: Composition-based stats.
 Identities = 75/229 (32%), Positives = 106/229 (46%), Gaps = 21/229 (9%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYPQAESVH 61
           Q+  L ILY+D  I+ VNKP G++  P         V   +             +   VH
Sbjct: 79  QDMDLAILYEDRDIVAVNKPPGMVVHPAPGHSSNTLVNALLAHCKDLSGIGGVQRPGIVH 138

Query: 62  RLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPN 121
           RLD  TSGVI+ A   AA   L  Q  +R  +K Y+A   G      G++DLPL     +
Sbjct: 139 RLDKETSGVILAAKNDAAHAGLSEQLAQRRVEKFYLALAHGVIKEDTGVIDLPLARHPSD 198

Query: 122 RPKQKVCYE-TGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRF 180
           R +  V     G+ A + + V E   D    V ++  TGR+HQ+RVH+ AL HP++GD  
Sbjct: 199 RKRMHVSTPAKGREALSLWTVKERFLD-ATYVKVQIKTGRTHQIRVHLAALHHPVIGDTV 257

Query: 181 YASPEARAMAP-----------RLLLHAEMLTITHPAYGNSMTFKAPAD 218
           Y   + R   P           R +LHA +++ THP  G  +T  AP  
Sbjct: 258 YGGRKKRGRLPASVLGKAPPPERQMLHAHIVSFTHPVTGEKLTLTAPLP 306


>UniRef50_D2BIX0 Pseudouridine synthase n=5 Tax=Dehalococcoides RepID=D2BIX0_DEHSV
          Length = 302

 Score =  309 bits (794), Expect = 3e-83,   Method: Composition-based stats.
 Identities = 74/217 (34%), Positives = 110/217 (50%), Gaps = 12/217 (5%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQ--------RDYPQAESVH 61
           ++  L I++QD  ++++NKP GL   P         +   +          D  +   VH
Sbjct: 76  EDIPLEIIFQDKDLLLINKPPGLTVHPAPGHPDHTLINGVLALEPKMEDFDDPLRPGIVH 135

Query: 62  RLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPN 121
           RLD  TSG+++VA  +     L  QF+ER  +K Y+  V G   PAEG ++ PL  D  N
Sbjct: 136 RLDKDTSGLLLVAKNRETLANLSAQFKERTVRKYYLTLVKGELHPAEGFIEAPLGRDPQN 195

Query: 122 RPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFY 181
           R K  V    G+ A+T Y+V+ Y     + + +K  TGR+HQ+RVH  A+GHP+ GD  Y
Sbjct: 196 RQKIAVVS-NGRHARTGYKVLRYI-QGYSLLEVKLETGRTHQIRVHFAAIGHPVAGDAIY 253

Query: 182 ASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
              E      R  LHA  L+ T P+ G ++ F +P  
Sbjct: 254 GQKET--WLKRQFLHAHRLSFTLPSNGQTVEFTSPLP 288


>UniRef50_D1ANU4 Pseudouridine synthase n=14 Tax=Fusobacteriaceae RepID=D1ANU4_SEBTE
          Length = 305

 Score =  309 bits (793), Expect = 5e-83,   Method: Composition-based stats.
 Identities = 65/225 (28%), Positives = 102/225 (45%), Gaps = 11/225 (4%)

Query: 2   GMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------D 53
             E    P+   + ILY+D  I V++K +G++  P    E    V   +           
Sbjct: 65  EKEIDLVPENINIKILYEDSDIAVIDKEAGIVVHPSHGHESGTLVNAVMYHIKDLSGING 124

Query: 54  YPQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDL 113
             +   VHRLD  TSG++++A    A   L   F     +K Y+A + G  +   G ++ 
Sbjct: 125 EIRPGIVHRLDKDTSGLLIIAKNDTAHLRLSEMFGSSGIRKTYIAILKGKINKESGKLET 184

Query: 114 PLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGH 173
            +  D  +R K  V    GK A T ++V++   +  + V +   TGR+HQ+RVHM  LG+
Sbjct: 185 LIGRDPKDRKKMAVVKTNGKTAITYFQVLDKN-EKFSLVKVNIQTGRTHQIRVHMKYLGY 243

Query: 174 PILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           P+LGD  Y       +A R +LHA  L   HP    +M   +   
Sbjct: 244 PVLGDSVYGRD--NKIAGRQMLHAYKLEFLHPVTQKAMKIISELP 286


>UniRef50_A6SXT6 Pseudouridine synthase n=1 Tax=Janthinobacterium sp. Marseille
           RepID=A6SXT6_JANMA
          Length = 342

 Score =  309 bits (793), Expect = 5e-83,   Method: Composition-based stats.
 Identities = 69/225 (30%), Positives = 111/225 (49%), Gaps = 10/225 (4%)

Query: 3   MENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR-----DYPQA 57
            +    P+   L I+++D  ++V+NKP+GL+  P         +   +         P+A
Sbjct: 104 EDEAFKPEAMDLAIVHEDAEMLVINKPAGLVVHPAAGNWSGTLLNGLLHYLPSISGVPRA 163

Query: 58  ESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLIC 117
             VHRLD  TSG++VVA T  A  +L RQ + R  K++Y+A VWG P    G +D  +  
Sbjct: 164 GIVHRLDKDTSGLMVVAKTLIAHTDLVRQLQARTVKREYLALVWGTP-NITGKIDASIGR 222

Query: 118 DWPNRPKQKVCYE-TGKPAQTEYEVVEY---AADNTARVVLKPITGRSHQLRVHMLALGH 173
              +R K  V    T KPA T ++ +          + ++ +  TGR+HQ+RVHM ++G 
Sbjct: 223 HARDRIKMAVSENLTAKPAVTHFQRLATGMLDGRPVSLMLCRLETGRTHQIRVHMQSIGF 282

Query: 174 PILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
            ++GD  Y       + PR  LHA  L + HP  G ++ + +   
Sbjct: 283 ALVGDGLYGKQHLTTVFPRQALHARRLGLIHPVSGEAVEWSSELP 327


>UniRef50_A0L9J0 Pseudouridine synthase n=1 Tax=Magnetococcus sp. MC-1
           RepID=A0L9J0_MAGSM
          Length = 332

 Score =  309 bits (793), Expect = 5e-83,   Method: Composition-based stats.
 Identities = 76/243 (31%), Positives = 114/243 (46%), Gaps = 28/243 (11%)

Query: 3   MENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR---------- 52
             +   P+E  L IL++D+H++V+NKP+G++  PG    H   V   +            
Sbjct: 76  EPSTALPEEIALEILFEDEHLIVLNKPAGMVVHPGAGVNHGTLVNALLYHCGTPDNPHGG 135

Query: 53  -----DYPQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPA 107
                   +   VHRLD  TSG++V A    A   L RQF +R   ++Y+A   G P PA
Sbjct: 136 LSGIGGVIRPGIVHRLDKETSGIMVAAKQDHAHIHLSRQFEQRTIGRRYLALTRGIPQPA 195

Query: 108 EGLVDLPLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVH 167
           +G ++  +     +R K  V  + G+ A T Y+V+E      A +  +  +GR+HQ+RVH
Sbjct: 196 QGRIEGAIGRHPIHRTKMAVVEQGGRAAATRYKVLEPLGQ-FALIRCRLESGRTHQIRVH 254

Query: 168 MLALGHPILGDRFYA------------SPEARAMAPRLLLHAEMLTITHPAYGNSMTFKA 215
           M  +GHP++GD  Y               +      R  LHA  LT  HP  G  M+FK 
Sbjct: 255 MTHIGHPLVGDPLYGAQHKAPSHWPPLHRQRFDQFQRQALHAHTLTFIHPHTGEEMSFKR 314

Query: 216 PAD 218
           P  
Sbjct: 315 PPP 317


>UniRef50_C7RM94 Pseudouridine synthase n=11 Tax=Proteobacteria RepID=C7RM94_9PROT
          Length = 375

 Score =  309 bits (792), Expect = 6e-83,   Method: Composition-based stats.
 Identities = 77/222 (34%), Positives = 116/222 (52%), Gaps = 14/222 (6%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR-----DYPQAESVHRL 63
           P+E  L I+++DD ++V++K +GL+  PG        +   +         P+A  VHRL
Sbjct: 102 PEEIPLRIVFEDDTLIVLDKQAGLVVHPGSGNWRGTLLNGLLHHAPQLARVPRAGIVHRL 161

Query: 64  DMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRP 123
           D  T+G++VVA T  A+ +L RQ + R  K+ Y A V G      G+VD P+      R 
Sbjct: 162 DKDTTGLMVVAKTLEAQTDLVRQLQARSVKRCYQALVRGIV-EGAGIVDAPIGRHPTVRT 220

Query: 124 KQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYAS 183
           +  V    G+PA+T Y V+E        +     TGR+HQ+RVHM ++ HP++GD  Y  
Sbjct: 221 RMAVVS-GGRPARTHYRVLERFVA-CTLIECALETGRTHQIRVHMTSIAHPLVGDPIYGG 278

Query: 184 PEARAM----APRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
             +R       PR  LHA  L + HPA G +M +++  PAD 
Sbjct: 279 GASRVPQGAVFPRQALHACRLALVHPASGKAMLWRSGVPADM 320


>UniRef50_Q3AVX8 Pseudouridine synthase n=40 Tax=cellular organisms
           RepID=Q3AVX8_SYNS9
          Length = 339

 Score =  308 bits (790), Expect = 1e-82,   Method: Composition-based stats.
 Identities = 72/223 (32%), Positives = 110/223 (49%), Gaps = 11/223 (4%)

Query: 6   YNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYPQA 57
           Y  PQ   L +L++D+HI+V+NK +GL   P    +    V   +             + 
Sbjct: 98  YLKPQPMDLDVLFEDEHIIVLNKSAGLTVHPAPGNKDGTLVNGLLHHCPDLPGISGKLRP 157

Query: 58  ESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLIC 117
             VHRLD  TSG IVVA ++ A  +L+ Q ++R   ++Y A V G P    G +   +  
Sbjct: 158 GIVHRLDKDTSGCIVVAKSQEALVKLQVQIQKRVASREYFAVVHGVPDGDSGTIIGAVGR 217

Query: 118 DWPNRPKQKVC-YETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPIL 176
              +R K  V   E+G+ A+T + ++E   D  + +  K  TGR+HQ+RVH   + HP++
Sbjct: 218 HPVDRKKYAVVSDESGRYARTHWTLIERFGD-YSLLRFKLDTGRTHQIRVHCAHINHPVV 276

Query: 177 GDRFYAS-PEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           GD  Y+   +     P   LHA  L + HP  G  M F+AP  
Sbjct: 277 GDPTYSRCRKLPLDLPGQALHAVQLGLDHPITGERMVFEAPLP 319


>UniRef50_A9NGF1 Pseudouridine synthase n=1 Tax=Acholeplasma laidlawii PG-8A
           RepID=A9NGF1_ACHLI
          Length = 297

 Score =  307 bits (788), Expect = 2e-82,   Method: Composition-based stats.
 Identities = 75/226 (33%), Positives = 110/226 (48%), Gaps = 12/226 (5%)

Query: 2   GMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------- 52
              N   P+   L I+Y+DD IMV+NKP GL+  P         V   +           
Sbjct: 64  EETNPLKPKNIDLNIVYEDDDIMVINKPKGLVVHPSETFSETTLVSGLLHHTDTLSTHND 123

Query: 53  DYPQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVD 112
           D  +   +HR+D  TSG+I+VA T  A + L +  +  + K++Y+A V G     +G++D
Sbjct: 124 DPLRPGILHRIDKDTSGLILVAKTNEAHKILAQDLKSHDIKREYIALVEGVLDHNKGVID 183

Query: 113 LPLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALG 172
            P+      R K  V   TGKPA T +EV+    D+   +  K  TGR+HQ+RVH+  + 
Sbjct: 184 APIARHPKIRTKMAVV-ATGKPAITHFEVMRTFRDH-TLLHCKLETGRTHQIRVHLAYIK 241

Query: 173 HPILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           HP+ GD  Y +  A+ +    LLHA  L   HP     M  +AP  
Sbjct: 242 HPVTGDPLYGTK-AKILKDGQLLHAFRLEFVHPITKKVMMLEAPLP 286


>UniRef50_D1PCC3 Pseudouridine synthase n=1 Tax=Prevotella copri DSM 18205
           RepID=D1PCC3_9BACT
          Length = 387

 Score =  307 bits (788), Expect = 2e-82,   Method: Composition-based stats.
 Identities = 76/243 (31%), Positives = 109/243 (44%), Gaps = 29/243 (11%)

Query: 4   ENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR---------DY 54
           E    P+E  + ++Y+DD +MVVNK +G++  PG    H   +               + 
Sbjct: 121 ETSIKPEEIAINVVYEDDQLMVVNKEAGMVVHPGAGNFHGTLIQAVAWHLRDMPEFDAND 180

Query: 55  PQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLP 114
           P+   VHR+D  TSG++VVA T  A+  L +QF  +   + Y A VWG+    EG ++  
Sbjct: 181 PEVGLVHRIDKDTSGLLVVAKTPTAKNALGKQFFNKTTHRSYNALVWGNIVEDEGRIEGN 240

Query: 115 LICDWPNRPKQKVCYET---GKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLAL 171
           +  D  NR + KV       GK A T Y+V+E     T  V     TGR+HQ+R HM  +
Sbjct: 241 IGRDPKNRLRMKVFDPDSGIGKTAVTHYKVLERFG-YTTLVQCVLETGRTHQIRAHMKHI 299

Query: 172 GHPILGDRFYASPEARA----------------MAPRLLLHAEMLTITHPAYGNSMTFKA 215
           GHP+  D  Y   E                   + PR  LHA+ L   HP     M F +
Sbjct: 300 GHPLFMDETYGGTEILRGQRSSSYKAFIQNCFKLCPRQALHAKTLGFVHPTTKQQMDFDS 359

Query: 216 PAD 218
              
Sbjct: 360 EWP 362


>UniRef50_A6C0W7 Pseudouridine synthase n=1 Tax=Planctomyces maris DSM 8797
           RepID=A6C0W7_9PLAN
          Length = 342

 Score =  307 bits (787), Expect = 2e-82,   Method: Composition-based stats.
 Identities = 81/245 (33%), Positives = 114/245 (46%), Gaps = 32/245 (13%)

Query: 4   ENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDY--------- 54
           +N  PP++  + I+Y+DD I ++NKPS ++  PG+       +   +Q  +         
Sbjct: 83  DNRLPPEDIPIDIVYEDDWIAIINKPSDMIVHPGKGNYAGT-LAGALQYHFDQLSDVAGQ 141

Query: 55  PQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLP 114
            +   VHRLD  TSG++VVA       +L  QF +R+ +K+Y A VWG        +D  
Sbjct: 142 YRPGIVHRLDRNTSGIMVVAKDNQVHAKLSAQFEKRDVQKEYRAIVWGRMEFDTDYIDTF 201

Query: 115 LICDWPNRPKQKVCYETG--KPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALG 172
           +      R K  VC E G  + A T YEV+E        V LKP TGR+HQLRVHM  +G
Sbjct: 202 MCVHPRAREKMIVCDEGGNARNAFTYYEVIERY-QAFTYVRLKPRTGRTHQLRVHMQHIG 260

Query: 173 HPILGDRFYASPEARA-------------------MAPRLLLHAEMLTITHPAYGNSMTF 213
           H I+ DR Y   ++                     +  R  LHA  L   HP  G  M F
Sbjct: 261 HSIVADRVYGGHKSLKMKSLGIQAEADAAELESDVLIERQALHAYCLEFFHPQSGKPMKF 320

Query: 214 KAPAD 218
           +AP  
Sbjct: 321 EAPLP 325


>UniRef50_A9BMW0 Pseudouridine synthase n=10 Tax=Comamonadaceae RepID=A9BMW0_DELAS
          Length = 356

 Score =  307 bits (787), Expect = 2e-82,   Method: Composition-based stats.
 Identities = 78/220 (35%), Positives = 115/220 (52%), Gaps = 11/220 (5%)

Query: 8   PPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRD-----YPQAESVHR 62
            P++  L ++Y+D+H++VVNKP+GL+  P         +   + RD      P+A  VHR
Sbjct: 119 QPEDMALDVVYEDEHLLVVNKPAGLVVHPAPGNWTGTLLNGLLGRDPKAREVPRAGIVHR 178

Query: 63  LDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSP-AEGLVDLPLICDWPN 121
           LD  TSG++VVA ++AA   L      R+  +QY+A       P     VD P+  D  N
Sbjct: 179 LDKDTSGLMVVARSRAAMDALVAMIAARDVSRQYLALAHKAWGPRKHREVDAPIGRDPRN 238

Query: 122 RPKQKVCY---ETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGD 178
           R +  V       GK A+T+ +++    +  + V     TGR+HQ+RVHM +LGHP++ D
Sbjct: 239 RLRMAVVDLAQHAGKTARTDIDLLA-GNEEVSLVRCTLHTGRTHQIRVHMASLGHPLVAD 297

Query: 179 RFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
             Y   EA  MA R  LHA  L  THP  G ++  +AP  
Sbjct: 298 AVYGGKEAGGMA-RQALHAFRLAFTHPMTGQALVLRAPLP 336


>UniRef50_D0MJ49 Pseudouridine synthase n=2 Tax=Bacteria RepID=D0MJ49_RHOM4
          Length = 355

 Score =  307 bits (787), Expect = 2e-82,   Method: Composition-based stats.
 Identities = 80/256 (31%), Positives = 106/256 (41%), Gaps = 52/256 (20%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------------------- 52
           L I+Y+D +++VVNK +GL+  P R       V   +                       
Sbjct: 86  LDIVYEDPYLIVVNKQAGLVVHPARGNRSGTLVNALLYYIGSGPVRFDEEDDLPEDDEIG 145

Query: 53  -------------DYPQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVAR 99
                        + P+   VHRLD  T+G+IVVA        L RQF  R   + Y+A 
Sbjct: 146 LSMVSTGPTEAKLEAPRPGIVHRLDKDTTGLIVVAKDDVTHTGLARQFEHRTIARTYLAI 205

Query: 100 VWGHPSPAEGLVDLPLICDWPNRPKQKVCYET-GKPAQTEYEVVEYAADNTARVVLKPIT 158
           VWG P P  G ++  +  D  +R +  V  +  GK A T YEVVE      A V  K  T
Sbjct: 206 VWGVPDPPRGRIEAAIGRDPRDRQRMAVVPDDRGKRAVTHYEVVEALPA-AALVRFKLET 264

Query: 159 GRSHQLRVHMLALGHPILGDRFYASPEARAM----------------APRLLLHAEMLTI 202
           GR+HQ+RVH   +GHP+LGD  Y     R                    R  LHA  L  
Sbjct: 265 GRTHQIRVHARHIGHPVLGDPTYGGRTIRYGPHTPRRRAFYDQLFARLTRQALHAHTLGF 324

Query: 203 THPAYGNSMTFKAPAD 218
            HP  G  + F+AP  
Sbjct: 325 RHPRTGEWLEFEAPLP 340


>UniRef50_Q49WX8 Pseudouridine synthase n=1 Tax=Staphylococcus saprophyticus subsp.
           saprophyticus ATCC 15305 RepID=Q49WX8_STAS1
          Length = 305

 Score =  307 bits (787), Expect = 2e-82,   Method: Composition-based stats.
 Identities = 62/224 (27%), Positives = 99/224 (44%), Gaps = 11/224 (4%)

Query: 3   MENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DY 54
           +E    P+   L I Y+DD + +V KP G++  P         V   + +          
Sbjct: 70  VEADIQPENLNLDIYYEDDDVAIVYKPKGMVVHPSAGHYTGTLVNGLMYQMKNLSGINGE 129

Query: 55  PQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLP 114
            +   VHR+D  TSG+++VA    A R L  Q   +   ++YVA V G      G VD P
Sbjct: 130 IRPGIVHRIDKDTSGLLMVAKNDVAHRSLVDQLVNKTVTRKYVALVHGKIPHDYGTVDAP 189

Query: 115 LICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHP 174
           +  +  +R    V  + GK A T + V+E+  +    +  +  TGR+HQ+RVHM  +G+P
Sbjct: 190 IGRNKNDRQSMDVV-DDGKEAVTHFNVLEHF-NKYTLIECQLETGRTHQIRVHMKYIGYP 247

Query: 175 ILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           ++GD  Y   +         LHA ++   HP     +       
Sbjct: 248 LVGDPKYGPKKTLD-IGGQALHAGIIGFEHPVTHEYIEKSTALP 290


>UniRef50_A1URK8 Pseudouridine synthase n=2 Tax=Bartonella RepID=A1URK8_BARBK
          Length = 336

 Score =  306 bits (786), Expect = 3e-82,   Method: Composition-based stats.
 Identities = 83/248 (33%), Positives = 114/248 (45%), Gaps = 35/248 (14%)

Query: 6   YNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR---------DYPQ 56
           Y   +   L IL++DDHI+VVNKP+GL+  PG        V   I              +
Sbjct: 72  YPEGEAIPLHILFEDDHIIVVNKPAGLVVHPGHGNWTGTLVNALIYHCGDSLSGIGGVRR 131

Query: 57  AESVHRLDMATSGVIVVALTKAAERELKRQFRER----EPKKQYVARVWGHPSPAEGLVD 112
              VHRLD  TSGVIVVA    A + L  QF +        ++Y A +WG P+   G++ 
Sbjct: 132 PGIVHRLDKNTSGVIVVAKNDLAHKGLSAQFSDHGRTGVLDRRYHALIWGSPNRNIGVIT 191

Query: 113 LPLICDWPNRPKQKVCYET---GKPAQTEYEVVEYAADNT------ARVVLKPITGRSHQ 163
             L     +R KQ V +      + A T + V+E            + +  +  TGR+HQ
Sbjct: 192 ASLGRARYDRTKQAVIHSHNIYARHAVTHFSVIEKYQTCADKIPFASLLECRLETGRTHQ 251

Query: 164 LRVHMLALGHPILGDRFYAS-------------PEARAMAPRLLLHAEMLTITHPAYGNS 210
           +RVHM  +GHP++GD  Y +              EA  +  R  LHA  LT  HPA GN 
Sbjct: 252 IRVHMAHIGHPLVGDTVYGNAFKTKSNRFDSTIKEAIDLFNRQALHAASLTFEHPAKGNI 311

Query: 211 MTFKAPAD 218
           M+F AP  
Sbjct: 312 MSFSAPLP 319


>UniRef50_A7NB61 Pseudouridine synthase n=18 Tax=Francisella RepID=A7NB61_FRATF
          Length = 332

 Score =  306 bits (786), Expect = 3e-82,   Method: Composition-based stats.
 Identities = 69/220 (31%), Positives = 109/220 (49%), Gaps = 14/220 (6%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRD-----YPQAESVHRLD 64
           ++  L I+++DD I+V++KP  ++  PG            + R       P+A  VHRLD
Sbjct: 84  EDINLKIIFEDDDIIVIDKPVNMIVHPGAGNPTGTVSNALLHRYKDQDKLPRAGIVHRLD 143

Query: 65  MATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPK 124
             TSG++V A +  A   L +Q  ER+  ++Y+A V G     +G ++ P+  D  NR K
Sbjct: 144 KDTSGLMVAAKSSIAYHNLVQQLAERKVSRKYLAIVEGEIYQ-QGTINQPIGRDPTNRTK 202

Query: 125 QKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASP 184
             + Y  GK A T Y  +E   D    +  +  TGR+HQ+RVHM ++ HP++GD+ Y   
Sbjct: 203 MAINYR-GKEAITYYTPIEVY-DGFTLIECQLETGRTHQIRVHMKSIKHPLVGDQTYNKS 260

Query: 185 EAR------AMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
             +       +  R  LHA  L+  HP     + FK+   
Sbjct: 261 STKLEKLAITIPTRQALHAYKLSFIHPTTAKMVKFKSKLP 300


>UniRef50_D1RB31 Pseudouridine synthase n=1 Tax=Parachlamydia acanthamoebae str.
           Hall's coccus RepID=D1RB31_9CHLA
          Length = 319

 Score =  306 bits (786), Expect = 3e-82,   Method: Composition-based stats.
 Identities = 74/224 (33%), Positives = 108/224 (48%), Gaps = 16/224 (7%)

Query: 7   NPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR----------DYPQ 56
             P++  L ILY+D+H++++NKP G++  P         V   +            D  +
Sbjct: 80  LIPEQIPLNILYEDEHLLIINKPVGMVVHPAPGNWTGTFVNALLYHCGYSLSDASVDSIR 139

Query: 57  AESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLI 116
              VHRLD  TSGV+V A T + +++L   F  R+  K+Y A   G+P   E  ++ P+ 
Sbjct: 140 PGIVHRLDKETSGVLVAAKTLSVQQKLMELFAARQVYKEYWAICLGNPGNCE--LNWPIG 197

Query: 117 CDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPIL 176
               +R +  V  E GK A T  E +E   +      L   TGR+HQ+RVH+   GHPIL
Sbjct: 198 RHPIHRKQMTV-REDGKEALTFCETLE-VGNEICLAKLILSTGRTHQIRVHLKHKGHPIL 255

Query: 177 GDRFYASPEA--RAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           GD  Y S +   R  A R +LHA  L   HP     +  +AP  
Sbjct: 256 GDSIYGSKQVNMRYRAERQMLHARKLAFIHPITQQKIEVEAPLP 299


>UniRef50_O50310 Uncharacterized RNA pseudouridine synthase Cpar_0723 n=13
           Tax=Chlorobiaceae RepID=Y723_CHLP8
          Length = 327

 Score =  306 bits (786), Expect = 3e-82,   Method: Composition-based stats.
 Identities = 72/240 (30%), Positives = 104/240 (43%), Gaps = 29/240 (12%)

Query: 7   NPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP----------Q 56
             P++  + ILY+DD +MV++K +G++  P             +               +
Sbjct: 70  LAPEDIPITILYEDDDLMVIDKEAGMVVHPAFGNWTGTLANAILHHLGKDADELDKTEMR 129

Query: 57  AESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLI 116
              VHRLD  TSG+I++A    A  +L RQF  R+ +K Y A VWG P    G +   + 
Sbjct: 130 PGIVHRLDKDTSGLIIIAKNPTALHKLARQFANRQVEKVYKAIVWGVPKAESGTIKTNIG 189

Query: 117 CDWPNRPKQK---VCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGH 173
               NR            GK A T+Y+VVE      + + +   TGR+HQ+RVH+  LGH
Sbjct: 190 RSHKNRKVMANFPYEGAEGKHAITDYQVVEDLG-YFSLMDVTLHTGRTHQIRVHLQHLGH 248

Query: 174 PILGDRFYASPEAR---------------AMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
            ILGD  Y     R                +  R  LHA+ L    P  G  ++F AP  
Sbjct: 249 SILGDETYGGATPRTLPFSKSEPFTRNLLELMSRQALHAQTLRFRQPTTGEPLSFSAPLP 308


>UniRef50_A6DUC9 Pseudouridine synthase n=1 Tax=Lentisphaera araneosa HTCC2155
           RepID=A6DUC9_9BACT
          Length = 323

 Score =  305 bits (784), Expect = 5e-82,   Method: Composition-based stats.
 Identities = 79/234 (33%), Positives = 110/234 (47%), Gaps = 17/234 (7%)

Query: 2   GMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDY------- 54
             E+   P++  L I+Y+DD I+VVNKP+G++  PG        V   + RD        
Sbjct: 78  ADESTLLPEDIELDIIYEDDDILVVNKPAGMVVHPGAGNYTGTLVNALLGRDLDTFSAMD 137

Query: 55  ---PQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLV 111
               +   VHRLD  TSGVI+VA +     +L R F  R+ +K YVA   G        +
Sbjct: 138 DGSSRPGIVHRLDKETSGVIIVAKSAKNLDKLSRSFARRDVEKYYVALCRGTIRVGRDTI 197

Query: 112 DLPLICDWPNRPKQ--KVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHML 169
              +     NR K         GK A + Y+V+    +    V LK  TGR+HQ+RVHM 
Sbjct: 198 TSHIGRSRSNRQKMENTNDSNRGKEAISHYKVLA-DNNGATLVKLKIDTGRTHQIRVHMS 256

Query: 170 ALGHPILGDRFYASP--EARAMAPRLLLHAEMLTITHPAYGNSMTFKAPA--DF 219
            + HP++GD+ Y     + +    R +LHA    I HP     MTF AP   DF
Sbjct: 257 GINHPVVGDKLYGVRRLDEKESPDRHILHAWRTRIIHPGTQEIMTFTAPLHDDF 310


>UniRef50_P74346 Uncharacterized RNA pseudouridine synthase slr1629 n=19
           Tax=Bacteria RepID=Y1629_SYNY3
          Length = 327

 Score =  305 bits (784), Expect = 5e-82,   Method: Composition-based stats.
 Identities = 68/220 (30%), Positives = 111/220 (50%), Gaps = 12/220 (5%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYPQAESVH 61
           Q   L ILY+D+ ++++NKP+GL+  PG        V   +             +   VH
Sbjct: 94  QNIPLDILYEDEQLIIINKPAGLVVHPGPGHPDGTVVNALLAHCPDLAGIGGVQRPGIVH 153

Query: 62  RLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPN 121
           RLD  T+G +VVA T+ A   L+ Q +E+  ++ Y   V+G P   +G V+LP+     +
Sbjct: 154 RLDKDTTGAMVVAKTELALHNLQVQLKEKTARRLYWGIVYGSPKEIQGTVNLPVGRHPGD 213

Query: 122 RPKQKVCY--ETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDR 179
           R K  +    + G+ A T + ++E   ++ + +  +  TGR+HQ+RVH   +GHP++GD 
Sbjct: 214 RQKMGIVPVEKGGREAVTHWRLLERIGNH-SWLEFQLETGRTHQIRVHSKQMGHPLVGDN 272

Query: 180 FY-ASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
            Y +        P   LHA  L++ HP  G  +T  AP  
Sbjct: 273 LYTSPGSVNVNLPGQALHAHQLSLIHPVSGEIITAIAPMP 312


>UniRef50_A5GW76 Pseudouridine synthase n=1 Tax=Synechococcus sp. RCC307
           RepID=A5GW76_SYNR3
          Length = 316

 Score =  304 bits (780), Expect = 1e-81,   Method: Composition-based stats.
 Identities = 68/223 (30%), Positives = 109/223 (48%), Gaps = 11/223 (4%)

Query: 6   YNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYPQA 57
           Y  P+   L +L++D+H++V+NKP+GL   P    +    V   +             + 
Sbjct: 80  YLQPEPMDLDVLFEDEHLIVINKPAGLTVHPAPGNKDGTLVNGLLHHCPDLPGISGKLRP 139

Query: 58  ESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLIC 117
             VHRLD  T+G IV+A ++ A  +L+ Q ++R   ++Y+A V G P+   G +   +  
Sbjct: 140 GIVHRLDKDTTGCIVIAKSQQALVKLQVQIQKRVASREYLAVVHGVPAGESGTIVGAIGR 199

Query: 118 DWPNRPKQKVC-YETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPIL 176
              +R K  V   + G+ A T + + E   D  + +  K  TGR+HQ+RVH     HP++
Sbjct: 200 HPVDRKKYAVVSSDNGRYACTHWSLQERLGD-YSLLRFKLDTGRTHQIRVHCAHRNHPVV 258

Query: 177 GDRFYAS-PEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           GD  Y+   +     P   LHA  L + HP  G  M F+AP  
Sbjct: 259 GDPTYSRCRKLPIELPGQALHAVQLGLDHPITGERMVFEAPLP 301


>UniRef50_Q312A0 Pseudouridine synthase, RluD n=6 Tax=Bacteria RepID=Q312A0_DESDG
          Length = 578

 Score =  304 bits (780), Expect = 2e-81,   Method: Composition-based stats.
 Identities = 70/233 (30%), Positives = 107/233 (45%), Gaps = 25/233 (10%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP--------QAESV 60
           P+E  L +LY+D H++V+NKP+GL   P         ++ R+   +P        +   V
Sbjct: 114 PEEGELEVLYRDAHMLVINKPAGLTVHPAPSCPEGT-LVHRLLHHFPELEAQEGFRPGIV 172

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HR+D  TSG++++ALT+ A   L   F  R   K+Y+A V G P    G +D P+     
Sbjct: 173 HRIDKDTSGLLLIALTEKARLALSDAFAGRRIHKEYLALVKGIPEGDSGEIDAPVGRHPT 232

Query: 121 NRPKQKVCYETGKPAQTEYEVVEYA-----ADNTARVVLKPITGRSHQLRVHMLALGHPI 175
           ++ +  V    G+ A + + V+              V ++  TGR+HQ+RVHM   GHP+
Sbjct: 233 HKTRMAVVR-GGREALSTWRVLLADPHGGGGTGWTLVAVRIHTGRTHQIRVHMQHTGHPL 291

Query: 176 LGDRFYASPEARAMAP----------RLLLHAEMLTITHPAYGNSMTFKAPAD 218
            GD  Y     R              R +LHA  ++  HP  G  M F  P  
Sbjct: 292 WGDALYGGMPGREELQTTPALAQTATRQMLHAWKISFDHPVTGAPMQFTLPPP 344


>UniRef50_C6WV38 Pseudouridine synthase n=3 Tax=Proteobacteria RepID=C6WV38_METML
          Length = 368

 Score =  304 bits (780), Expect = 2e-81,   Method: Composition-based stats.
 Identities = 81/223 (36%), Positives = 113/223 (50%), Gaps = 21/223 (9%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRI-----QRDYPQAESVHRLD 64
           Q+  L I+Y+DDHI+VVNKP+G++  P         +   +       D P+A  VHRLD
Sbjct: 86  QDIPLDIVYEDDHILVVNKPAGMVVHPAAGNWDGTLLNALLFHAPQLHDVPRAGIVHRLD 145

Query: 65  MATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPK 124
             TSG++VVA T  A+  L RQ + R  K++Y A VWG      G+VD PL  D  +R K
Sbjct: 146 KETSGLLVVAKTLNAQTHLVRQLQARTVKREYRAIVWGQL-WRNGVVDQPLGRDPRSRTK 204

Query: 125 QKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYAS- 183
             +    GKPA T YE++E  +     +     TGR+HQ+RVHM  L  P++GD  Y   
Sbjct: 205 MAINR-MGKPAITRYEILERFSVQ-TYLRCNLETGRTHQIRVHMQHLKAPLVGDPVYGFR 262

Query: 184 ------------PEARAMAPRLLLHAEMLTITHPAYGNSMTFK 214
                        +A +   R  LHA  L + HPA    M ++
Sbjct: 263 GIVPIRAMTQTLRDAVSQFHRQALHAIKLGLVHPATNEFMEWQ 305


>UniRef50_C6BSG2 Pseudouridine synthase, RluA family n=1 Tax=Desulfovibrio
           salexigens DSM 2638 RepID=C6BSG2_DESAD
          Length = 549

 Score =  303 bits (779), Expect = 2e-81,   Method: Composition-based stats.
 Identities = 82/239 (34%), Positives = 120/239 (50%), Gaps = 22/239 (9%)

Query: 2   GMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP------ 55
                  P+E  L I+Y D  I V+NKP+GL + P         ++ R+   +P      
Sbjct: 82  AELTSLVPEELPLEIIYNDGKIAVINKPAGLTTHPAPSCPTGT-LVHRMIHHFPEIRDMD 140

Query: 56  --QAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDL 113
             +   VHRLD  TSG+I VAL +     +   F +RE  K Y+A V G P    G +D 
Sbjct: 141 EWRPGIVHRLDKFTSGLITVALNEHDRLAMSTAFADREVNKAYLAIVHGVPKREFGEIDQ 200

Query: 114 PLICDWPNRPKQKVCYETGKPAQTEYEVVEY-AADNTARVVLKPITGRSHQLRVHMLALG 172
           P+     ++ K  V  + G+ A++EYEV+    A   + V +K  TGR+HQ+RVHM  +G
Sbjct: 201 PMGRHPVHKTKMAVVLKGGRDARSEYEVLWSDPAGRASLVKVKIYTGRTHQIRVHMAHIG 260

Query: 173 HPILGDRFYAS----------PEARAMAPRLLLHAEMLTITHPAYGNSMTFK-APA-DF 219
           HP++GD+ Y S          P+   +A R +LHA  L+ THP     ++F  AP  DF
Sbjct: 261 HPLVGDQVYGSMPHAIWEQDQPQLAKLAERQMLHAYSLSFTHPDSEEELSFTQAPPEDF 319


>UniRef50_C7H7W3 Ribosomal large subunit pseudouridine synthase D n=2
           Tax=Faecalibacterium prausnitzii RepID=C7H7W3_9FIRM
          Length = 314

 Score =  303 bits (779), Expect = 2e-81,   Method: Composition-based stats.
 Identities = 67/222 (30%), Positives = 98/222 (44%), Gaps = 13/222 (5%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR---------DYPQAES 59
           PQE  L I+Y+D H++VVNKP G++  P         V   +              +   
Sbjct: 75  PQEIPLDIIYEDAHLLVVNKPKGMVVHPAPGNPDGTLVNALLWHCKGSLSGIGGEIRPGI 134

Query: 60  VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDW 119
           VHR+D  TSG++VVA   A    L +Q      ++ Y   V+G  +  EG V+  L    
Sbjct: 135 VHRVDKDTSGLLVVAKDDATHIGLSQQMAVHSVERAYNTIVYGGFAQDEGFVESNLGRSK 194

Query: 120 PNRPKQKV---CYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPIL 176
            +R K  V        K A T Y+V+E   +    +  +  TGR+HQ+RVHM ++ HP+ 
Sbjct: 195 TDRKKMAVYPASEPHTKYAYTGYKVLERLGE-FTMLECRLKTGRTHQIRVHMASIHHPVA 253

Query: 177 GDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           GD  Y             LHA+ L   HP  G  + F +   
Sbjct: 254 GDPVYGPHNCITSLHGQCLHAKTLGFIHPITGEHLRFDSELP 295


>UniRef50_A7HV45 Pseudouridine synthase n=56 Tax=Alphaproteobacteria
           RepID=A7HV45_PARL1
          Length = 482

 Score =  303 bits (779), Expect = 2e-81,   Method: Composition-based stats.
 Identities = 80/241 (33%), Positives = 103/241 (42%), Gaps = 32/241 (13%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR---------DYPQAESV 60
           Q   L I+Y+D  ++VV KP+GL+  P         V   +              +   V
Sbjct: 222 QAIPLEIVYEDADLIVVMKPAGLVVHPAPGNPDMTLVNALVAHCGETLSGIGGEKRPGIV 281

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFRER----EPKKQYVARVWGHPSPAEGLVDLPLI 116
           HRLD  TSG++VVA T  A + L  QF       +  + Y A  WG P   +G VD  + 
Sbjct: 282 HRLDKETSGLMVVAKTDRAHQGLSAQFAAHGRDGKLTRAYTALTWGVPQTRKGTVDANIA 341

Query: 117 CDWPNRPKQKVCYE-----TGKPAQTEYEVVEYAADN-TARVVLKPITGRSHQLRVHMLA 170
               NR K     +      G+ A T Y V    AD   A V  +  TGR+HQ+RVHM A
Sbjct: 342 RSSHNRSKMATVRDRGEETGGRIAITHYTVKTDYADGLVAEVECRLETGRTHQIRVHMTA 401

Query: 171 LGHPILGDRFYASP-------------EARAMAPRLLLHAEMLTITHPAYGNSMTFKAPA 217
           LGHP+LGD  Y +               A     R  LHA  L   HP  G  M+F AP 
Sbjct: 402 LGHPLLGDATYGTGMKSRKSKLSPEAQAALERLNRQALHAHHLGFEHPVAGEKMSFDAPL 461

Query: 218 D 218
            
Sbjct: 462 P 462


>UniRef50_P65834 Ribosomal large subunit pseudouridine synthase D n=321
           Tax=Gammaproteobacteria RepID=RLUD_ECOL6
          Length = 326

 Score =  303 bits (778), Expect = 3e-81,   Method: Composition-based stats.
 Identities = 77/235 (32%), Positives = 111/235 (47%), Gaps = 20/235 (8%)

Query: 1   MGMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRD-----YP 55
           +  E    PQ+  L I+Y+D+ I+V+NKP  L+  PG        +   +         P
Sbjct: 71  IEEEARFEPQDIPLDIVYEDEDIIVINKPRDLVVHPGAGNPDGTVLNALLHYYPPIADVP 130

Query: 56  QAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPL 115
           +A  VHRLD  T+G++VVA T  A+  L    + RE  ++Y A   GH +   G VD P+
Sbjct: 131 RAGIVHRLDKDTTGLMVVAKTVPAQTRLVESLQRREITREYEAVAIGHMTAG-GTVDEPI 189

Query: 116 ICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPI 175
                 R    V +  GKPA T Y ++E+   +  R+ L+  TGR+HQ+RVHM  + HP+
Sbjct: 190 SRHPTKRTHMAV-HPMGKPAVTHYRIMEHFRVH-TRLRLRLETGRTHQIRVHMAHITHPL 247

Query: 176 LGDRFYASPE------------ARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           +GD  Y                      R  LHA ML + HP  G  M + AP  
Sbjct: 248 VGDPVYGGRPRPPKGASEAFISTLRKFDRQALHATMLRLYHPISGIEMEWHAPIP 302


>UniRef50_B8K915 Pseudouridine synthase n=5 Tax=Vibrio RepID=B8K915_VIBPA
          Length = 254

 Score =  303 bits (777), Expect = 3e-81,   Method: Composition-based stats.
 Identities = 125/219 (57%), Positives = 157/219 (71%), Gaps = 1/219 (0%)

Query: 1   MGMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESV 60
           M M  YNPP+EPW+ I+++D+HI+V NKPSGLLSVPGRLEEH DS+ +R+   YP  + V
Sbjct: 10  MAMTEYNPPREPWVDIVFEDEHILVANKPSGLLSVPGRLEEHYDSLWSRLVAIYPDIQVV 69

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLDM TSG++++A  K AER LK+QF+ R   K Y ARVWGHP+   G +DLPLICDWP
Sbjct: 70  HRLDMDTSGLMLLAKHKEAERSLKKQFQYRLTHKVYYARVWGHPTNDNGEIDLPLICDWP 129

Query: 121 NRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRF 180
           NRP+Q VC++ GKP++T Y+VV+   + T+ V L PITGRSHQLRVHM ALGHPI+GD F
Sbjct: 130 NRPRQIVCFDDGKPSKTLYQVVKR-EERTSIVRLLPITGRSHQLRVHMQALGHPIVGDEF 188

Query: 181 YASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
           Y+  EA   + RL LHA  L+  HP          P DF
Sbjct: 189 YSEGEAFEFSDRLELHAAELSFYHPHSEALQCAFVPCDF 227


>UniRef50_D1BAB3 Pseudouridine synthase n=1 Tax=Thermanaerovibrio acidaminovorans
           DSM 6589 RepID=D1BAB3_THEAS
          Length = 320

 Score =  302 bits (775), Expect = 6e-81,   Method: Composition-based stats.
 Identities = 77/226 (34%), Positives = 107/226 (47%), Gaps = 12/226 (5%)

Query: 2   GMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRD-------- 53
             E    PQ+    ++YQD  ++VV+KP+GL+  P         V   + R         
Sbjct: 84  SEELELEPQDVPFRVVYQDQDLVVVDKPAGLVVHPAPGHWRGTLVHGLLYRYPDLMELNG 143

Query: 54  YPQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDL 113
             +   VHRLD  TSG++VVA    A   L R F++R   K Y+A   G     EG V L
Sbjct: 144 VKRPGIVHRLDATTSGLMVVARNGLAMEGLVRAFKDRRVGKVYLAMAAGTLR-GEGSVSL 202

Query: 114 PLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGH 173
           P+  D  NR +       G+ A T Y V+  +    + V  +  TGR+HQ+RVHM +LGH
Sbjct: 203 PIGRDPDNRKRMACV-PWGREALTRYRVIW-SRGGYSLVACQIKTGRTHQIRVHMRSLGH 260

Query: 174 PILGDRFYASP-EARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           P++GDR Y  P        R+ LH+  L   HP  G  M+F  P  
Sbjct: 261 PLVGDRIYGGPCPEGFPLGRVFLHSWRLEFDHPRTGAPMSFICPLP 306


>UniRef50_C8PVB8 Pseudouridine synthase n=2 Tax=Moraxellaceae RepID=C8PVB8_9GAMM
          Length = 380

 Score =  302 bits (774), Expect = 7e-81,   Method: Composition-based stats.
 Identities = 71/235 (30%), Positives = 106/235 (45%), Gaps = 25/235 (10%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRD-----YPQAESVHRL 63
           P+   L ILY+D+ ++V+NKP GL+  PG        V   +         P+A  VHR+
Sbjct: 138 PENIPLDILYEDEAVLVINKPVGLVVHPGAGNGSGTLVNALLFHYPDSRTLPRAGLVHRI 197

Query: 64  DMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSP--AEGLVDLPLICDWPN 121
           D  TSG++V+A    ++  L  Q +++   + Y A V    +       +D P+      
Sbjct: 198 DKETSGLMVIAKDSQSQLHLINQLKDKSVYRLYQAIVLASAAELARHRTIDAPIGRHPTQ 257

Query: 122 RPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFY 181
           R K  V    GKPA T  E +   +D  + V ++  TGR+HQ+RVH+  LG P+LGD  Y
Sbjct: 258 RTKMAVVSS-GKPAVTHLEKITAISDAVSLVSVRLETGRTHQIRVHLSNLGFPLLGDPLY 316

Query: 182 ASPEARAMA---------------PRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
            +    A+                 R  LHA  L   HP  G  +  +A  P D 
Sbjct: 317 GAARKNAILLKTLDDDQKHIVQQFQRQALHAYELGFIHPKTGEPIKVQARLPEDM 371


>UniRef50_D0RPR1 Pseudouridine synthase n=1 Tax=alpha proteobacterium HIMB114
           RepID=D0RPR1_9RICK
          Length = 325

 Score =  301 bits (773), Expect = 9e-81,   Method: Composition-based stats.
 Identities = 68/243 (27%), Positives = 102/243 (41%), Gaps = 25/243 (10%)

Query: 1   MGMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR-------- 52
           +       P++  L I+++D  I++++KP G++  PG        V   +          
Sbjct: 68  IEETINLIPKKMDLNIIFEDQDIIIIDKPIGMVVHPGAGNYEDTMVNGLLYHCKNNLSGM 127

Query: 53  -DYPQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLV 111
               +   VHR+D  TSG++VVA    A   + +QF E   K+ Y+  V+G   P  G +
Sbjct: 128 NGEDRPGIVHRIDKDTSGLLVVAKNDQAHAFIAKQFEEHSIKRSYLVFVYGILRPLHGKI 187

Query: 112 DLPLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADN----TARVVLKPITGRSHQLRVH 167
           +  +  +  NR K       GK A T YE +E    N     + V     TGR+HQ+RVH
Sbjct: 188 ETLIGRNKTNRQKMSADVIRGKDAITNYETLEVFKGNKIPDISLVKCILETGRTHQIRVH 247

Query: 168 MLALGHPILGDRFYASP------------EARAMAPRLLLHAEMLTITHPAYGNSMTFKA 215
           M   G+PILGD+ Y               E      R  LHA  L   HP     + F +
Sbjct: 248 MSHKGNPILGDQTYGKKIKKIRGIDQEFEEILKSLKRQALHAHTLGFIHPTTNEEVFFAS 307

Query: 216 PAD 218
              
Sbjct: 308 ELP 310


>UniRef50_D2L0S2 Pseudouridine synthase, RluA family n=1 Tax=Desulfovibrio sp.
           FW1012B RepID=D2L0S2_9DELT
          Length = 558

 Score =  301 bits (773), Expect = 1e-80,   Method: Composition-based stats.
 Identities = 75/228 (32%), Positives = 109/228 (47%), Gaps = 20/228 (8%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP--------QAESVH 61
           +   L +LY D  + V++KP GL   P         ++ R+   +P        +   VH
Sbjct: 87  EAGSLRVLYADKELAVLDKPPGLTVHPAPGLPEGT-LVNRLLHHFPGLREMAGERPGIVH 145

Query: 62  RLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPN 121
           RLD  TSG+++VALT+     L   F  R+  K Y+A V G P    G + LP+  D   
Sbjct: 146 RLDKDTSGLLMVALTEPVRLALAADFAARQVHKTYLALVHGRPDGKGGDIRLPIGRDPKY 205

Query: 122 RPKQKVCYETGKPAQTEYEVVEYAADNT-ARVVLKPITGRSHQLRVHMLALGHPILGDRF 180
           R K  V ++ G+PA + +  V  A D T + + +   TGR+HQ+RVHM A+GHPI+GD  
Sbjct: 206 RTKMAVPHKGGRPAHSRWRPVWTAPDGTASLLEVTIFTGRTHQIRVHMAAIGHPIIGDAV 265

Query: 181 YA----------SPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           Y                 +A R +LHA  L+ THP      +F  P  
Sbjct: 266 YGPHQHAAWKRRGGAIARLASRQMLHAWKLSFTHPVLKEPRSFTCPPP 313


>UniRef50_Q8XYX8 Ribosomal large subunit pseudouridine synthase D n=94
           Tax=Proteobacteria RepID=RLUD_RALSO
          Length = 358

 Score =  301 bits (772), Expect = 1e-80,   Method: Composition-based stats.
 Identities = 79/236 (33%), Positives = 120/236 (50%), Gaps = 21/236 (8%)

Query: 3   MENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRD-----YPQA 57
            EN    +   L ++Y+DD ++V+NKP+GL+  P         +   + R       P+A
Sbjct: 105 DENAFVAEPVDLDVVYEDDTLLVINKPAGLVVHPAAGNWSGTVLNGLLHRYPQAAGLPRA 164

Query: 58  ESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLIC 117
             VHRLD  TSG++VVA T  A+ +L RQ + R  K+ Y+A VWG  +P  G +D P+  
Sbjct: 165 GIVHRLDKETSGLMVVARTLPAQTDLVRQLQARTVKRTYLALVWGE-TPEAGTIDAPIGR 223

Query: 118 DWPNRPKQKVC-YETGKPAQTEYEVVEYA---ADNTARVVLKPITGRSHQLRVHMLALGH 173
           D  +R +  +    +GKPA+T ++ ++         + V  +  TGR+HQ+RVH  + GH
Sbjct: 224 DPRDRTRMAIIETASGKPARTHFKTLDVVDLGRAQVSLVQCQLETGRTHQIRVHFESEGH 283

Query: 174 PILGDRFY------ASPEA-----RAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           P+LGD  Y        P+       A   R  LHA  L + HPA G S+ + A   
Sbjct: 284 PLLGDPVYTRNFRRGRPQTIKAPLPAPFARQALHAVRLGLVHPASGQSVHWHAGVP 339


>UniRef50_A4WSV2 Pseudouridine synthase n=41 Tax=Alphaproteobacteria
           RepID=A4WSV2_RHOS5
          Length = 349

 Score =  300 bits (771), Expect = 2e-80,   Method: Composition-based stats.
 Identities = 67/250 (26%), Positives = 109/250 (43%), Gaps = 40/250 (16%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR---------DYPQAES 59
           P+   L ++++D  ++V++KP G++  P   +     V   +              +   
Sbjct: 85  PEAIPLSVVWEDADLIVIDKPVGMVVHPAPGQWTGTLVNALLHHCGASLSGIGGEKRPGI 144

Query: 60  VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPA----EG------ 109
           VHR+D  TSG++VVA T  A + L  QF     +++Y+A V G P P+     G      
Sbjct: 145 VHRIDKDTSGLLVVAKTDRAHQGLAAQFEAHTVERRYLALVHGVPEPSDPRLRGIRGVSF 204

Query: 110 ------LVDLPLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADN--TARVVLKPITGRS 161
                  +   +     +R +Q V +E G+ A T   ++E        A V  +  TGR+
Sbjct: 205 EPGGVLRIATGIARHRTDRQRQAVTFEGGRHAVTRARLLERFGTPPAAALVECRLETGRT 264

Query: 162 HQLRVHMLALGHPILGDRFYASPE-------------ARAMAPRLLLHAEMLTITHPAYG 208
           HQ+RVHM  +GH ++GD+ Y                 A    PR  LHA  L   HP  G
Sbjct: 265 HQIRVHMSHVGHGLIGDQTYGGRRKLSAKAVGAEAAQAAEAFPRQALHAATLGFCHPVTG 324

Query: 209 NSMTFKAPAD 218
             ++F++P  
Sbjct: 325 EDLSFESPLP 334


>UniRef50_D1VS73 Pseudouridine synthase n=1 Tax=Peptoniphilus lacrimalis 315-B
           RepID=D1VS73_9FIRM
          Length = 295

 Score =  300 bits (770), Expect = 2e-80,   Method: Composition-based stats.
 Identities = 62/213 (29%), Positives = 107/213 (50%), Gaps = 11/213 (5%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYPQAESVH 61
           ++    ++Y+D++I V++KP  L+   G        V   + +        D  +   VH
Sbjct: 71  EKIDFNVIYEDEYIAVISKPQDLVVHIGAGNSSGTLVNGLLYKFKNQLSDLDPLRPGIVH 130

Query: 62  RLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPN 121
           RLD  TSG++++A    A   L  QF+  + KK Y+A V G  +P  G++  P+  +  +
Sbjct: 131 RLDKNTSGLMIIAKNNQAHINLVDQFKNSQIKKYYLAIVHGK-TPESGIIAEPIGRNPND 189

Query: 122 RPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFY 181
           R K  V Y+  K A T+Y+ ++   +  + + +  +TGR+HQ+RVHM  +G+P+LGD  Y
Sbjct: 190 RKKMAVVYKNSKQAITKYKKLKEFQE-YSLLNINLLTGRTHQIRVHMAYIGYPVLGDIIY 248

Query: 182 ASPEARAMAPRLLLHAEMLTITHPAYGNSMTFK 214
               +     + +LH+  L   HP     M F 
Sbjct: 249 GRKNSLK-IDKQMLHSYKLIFNHPITNQKMEFT 280


>UniRef50_Q87AR7 Ribosomal large subunit pseudouridine synthase D n=18
           Tax=Gammaproteobacteria RepID=RLUD_XYLFT
          Length = 331

 Score =  300 bits (770), Expect = 2e-80,   Method: Composition-based stats.
 Identities = 82/227 (36%), Positives = 110/227 (48%), Gaps = 20/227 (8%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRD-----YPQAESVHRL 63
           PQ+  L ILY+D+H+ V+NKP+GL+  PG        V   + RD      P+A  VHRL
Sbjct: 85  PQDIPLDILYEDEHVFVINKPAGLVVHPGAGNPDGTLVNALLHRDPALAAVPRAGVVHRL 144

Query: 64  DMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRP 123
           D  TSGV+VVA T  A+  L  Q   R+  +QY+A V        G V+  +     +R 
Sbjct: 145 DKDTSGVMVVARTLQAQTALVEQLSSRQVHRQYLAVVVSALVSG-GTVNAAIERHPRDRL 203

Query: 124 KQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYAS 183
           + +V  +TGK A T Y + E    +TA    +  TGR+HQ+RVHM  L HPI+GDR Y  
Sbjct: 204 RMEV-SDTGKEAVTHYRLRERFRAHTAL-ECRLDTGRTHQIRVHMAHLRHPIVGDRLYGG 261

Query: 184 P------------EARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
                               R  LHAE+L   HP     +   AP  
Sbjct: 262 SLKLPKGGTDALVAMLRGFKRQALHAEVLEFLHPVRALPVRIVAPVP 308


>UniRef50_C6XNC0 Pseudouridine synthase n=1 Tax=Hirschia baltica ATCC 49814
           RepID=C6XNC0_HIRBI
          Length = 369

 Score =  300 bits (770), Expect = 2e-80,   Method: Composition-based stats.
 Identities = 69/262 (26%), Positives = 105/262 (40%), Gaps = 52/262 (19%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR---------DYPQAES 59
           P++  L +L++D+H++++NKP+GL+  P         V   +              +   
Sbjct: 93  PEDIPLDVLFEDEHLIILNKPAGLVVHPAPGSTSGTLVNALLHHCAGQLPGIGGVARPGI 152

Query: 60  VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDW 119
           VHRLD  TSGV+V A T+ A   L   F+    ++ Y+A   G P P  G ++  +    
Sbjct: 153 VHRLDKDTSGVMVAAKTEFAHTGLSSLFQAHFMERAYLAVTRGAPRPLLGKIETRIARST 212

Query: 120 PNRPKQKVCYE-------------------TGKPAQTEYEVVEYAAD--------NTARV 152
            +R K  V  E                    GK A T Y+V+E                 
Sbjct: 213 TDRKKMAVVRESRLSASAEWHGESEEDYEQKGKHAITNYKVLEQFGRIDATSGLPAATLT 272

Query: 153 VLKPITGRSHQLRVHMLALGHPILGDRFYAS----------------PEARAMAPRLLLH 196
             +  TGR+HQ+RVHM  +G P+LGD+ Y                    A     R  LH
Sbjct: 273 ECRLETGRTHQIRVHMAHIGAPLLGDQTYGRYRGLKAHGSGPAFETATHACKEFKRQALH 332

Query: 197 AEMLTITHPAYGNSMTFKAPAD 218
           A +L   HP  G ++ F+    
Sbjct: 333 AAILGFEHPVTGENLRFEVEPP 354


>UniRef50_C8WW59 Pseudouridine synthase n=2 Tax=Alicyclobacillus acidocaldarius
           RepID=C8WW59_ALIAD
          Length = 314

 Score =  299 bits (768), Expect = 4e-80,   Method: Composition-based stats.
 Identities = 74/222 (33%), Positives = 109/222 (49%), Gaps = 12/222 (5%)

Query: 5   NYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP--------Q 56
              P      V+ Y+DD ++VV+KP G++  PG        V   + R  P        +
Sbjct: 80  ELVPDDGVPFVVAYEDDDVIVVDKPRGVVVHPGAGHMRGTLVNGLLARGTPLCTLAGALR 139

Query: 57  AESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLI 116
              VHR+D  TSG++V A +  A R L   FR  + +++YVA   G     EG +D+P+ 
Sbjct: 140 PGVVHRIDKDTSGLVVFAKSDRAYRALVEAFRAHDVEREYVAIAHGRMPHREGTIDMPIA 199

Query: 117 CDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPIL 176
            D  +R +  V  + GK A T +EV+E  A   + + L+  TGR+HQ+RVH+ A+GHPI 
Sbjct: 200 RDPADRQRMAV-RQGGKRAVTHFEVLESFA-KYSYLRLRLETGRTHQIRVHLAAIGHPIA 257

Query: 177 GDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           GD  Y             LHA  L  THP  G  + F++   
Sbjct: 258 GDPVYGPRHT-LPIDGQALHARTLGFTHP-DGRRLRFESAVP 297


>UniRef50_B8GZR6 Pseudouridine synthase n=2 Tax=Caulobacter vibrioides
           RepID=B8GZR6_CAUCN
          Length = 342

 Score =  299 bits (768), Expect = 4e-80,   Method: Composition-based stats.
 Identities = 72/229 (31%), Positives = 100/229 (43%), Gaps = 22/229 (9%)

Query: 12  PWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR---------DYPQAESVHR 62
             L ILY+D H++VV+K +G+   P     +   V   +              +   VHR
Sbjct: 101 LPLSILYEDAHLIVVDKAAGMAVHPAPGTYNGTLVNALLHHCGASLSGVGGVARPGIVHR 160

Query: 63  LDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNR 122
           LD  TSGV+V A + AA R L   F   +  + YVA   G P+P  G +   +     +R
Sbjct: 161 LDKDTSGVMVAAKSDAAHRGLSTLFATHDIDRLYVALTRGAPNPPTGTIQTQIGRSPGDR 220

Query: 123 PKQKVCYETGKPAQTEYEVVEYAADN----TARVVLKPITGRSHQLRVHMLALGHPILGD 178
            K  V    G+ A T Y V            ARV  +  TGR+HQ+RVHM + G P LGD
Sbjct: 221 KKMAVLRAGGREAITHYRVEAAFGPADRPLAARVACRLETGRTHQIRVHMASKGSPCLGD 280

Query: 179 RFYASPE---------ARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
             Y + +           A   R  LHA +L   HP  G ++ F+ P  
Sbjct: 281 PVYGAAQPAAAVRERIEAAGLRRQALHAAVLGFVHPITGETLRFETPLP 329


>UniRef50_B9YI75 Pseudouridine synthase, RluA family n=1 Tax='Nostoc azollae' 0708
           RepID=B9YI75_ANAAZ
          Length = 329

 Score =  299 bits (767), Expect = 4e-80,   Method: Composition-based stats.
 Identities = 62/220 (28%), Positives = 105/220 (47%), Gaps = 12/220 (5%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYPQAESVH 61
           ++  L ILY+D+ ++++NKP+GL+  P         V   +             +   VH
Sbjct: 95  EDIPLDILYEDEQLLILNKPAGLVVHPAPGHLDGTLVNALLAHCANLPGIGGVQRPGIVH 154

Query: 62  RLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPN 121
           RLD  T+G I +A T  A + L+ Q + +  +++Y+  V+G P    G+++LP+     +
Sbjct: 155 RLDKDTTGAIAIAKTDIAYQHLQAQLQAKTARREYLGVVYGVPKTESGIINLPISRHPQD 214

Query: 122 RPKQKVCY--ETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDR 179
           R K  +    + G+ A T +++ E    N   +  +  TGR+HQ+RVH   +GHPI+GD 
Sbjct: 215 RKKMAIVPTEQGGRTAITHWQIRERL-SNYTLIHFQLETGRTHQIRVHSAKIGHPIVGDS 273

Query: 180 FYA-SPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
            Y              LHA  L + HP  G+ +   A   
Sbjct: 274 VYGAGRSVGVNLAGHALHAWQLKLQHPISGDWIQVTASPP 313


>UniRef50_Q1MQ60 Pseudouridylate synthases, 23S RNA-specific n=1 Tax=Lawsonia
           intracellularis PHE/MN1-00 RepID=Q1MQ60_LAWIP
          Length = 541

 Score =  298 bits (766), Expect = 6e-80,   Method: Composition-based stats.
 Identities = 77/228 (33%), Positives = 122/228 (53%), Gaps = 14/228 (6%)

Query: 2   GMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP------ 55
            + +   P+E +L IL+ D+H+ ++NKP GL   P      + +++ R+ + +P      
Sbjct: 71  EVVSALLPEEGFLEILFSDEHLAIINKPPGLTVHPAPS-CQESTLVHRLLKYFPKLIEQG 129

Query: 56  --QAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDL 113
             +   VHR+D  TSG++ +ALT+    +L + F +R+  K+Y+A V G PS  EG + +
Sbjct: 130 GLRPGIVHRIDKDTSGLLCIALTEDTRLKLSKIFLDRKINKEYLALVHGVPS-MEGYIAV 188

Query: 114 PLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADN-TARVVLKPITGRSHQLRVHMLALG 172
           PL  D   + K  V    GKPA TE+ V+    ++  + + L   TGR+HQ+RVHM  +G
Sbjct: 189 PLGRDPKTKVKVAV-NPKGKPAHTEWRVLHRGKNDVYSILALTIQTGRTHQIRVHMKHIG 247

Query: 173 HPILGDRFYASPEARAMA--PRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           HP++GD+ YA           R +LHA  L+  HP  G  M F  P  
Sbjct: 248 HPLVGDKLYAGGHVNKTFQCNRQMLHAWKLSFEHPITGKKMNFLCPPP 295


>UniRef50_C5VRN0 Pseudouridine synthase n=1 Tax=Clostridium botulinum D str. 1873
           RepID=C5VRN0_CLOBO
          Length = 302

 Score =  298 bits (766), Expect = 6e-80,   Method: Composition-based stats.
 Identities = 67/223 (30%), Positives = 112/223 (50%), Gaps = 10/223 (4%)

Query: 2   GMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ----- 56
             E    P++  L I+Y+D+ I+VVNKP G++  P +   +   +   +   +       
Sbjct: 71  KEEQDIIPEKMDLDIIYEDNDIIVVNKPKGIVVHPTKRHLNGT-LSNGVLYYFNDKNENS 129

Query: 57  -AESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPL 115
               V+RLDM TSG++++A    +   L R  ++ +  K+Y+A V G+ +   G++D P+
Sbjct: 130 IVRLVNRLDMDTSGLVLIAKNAYSHMALSRDMQKDDFVKKYLAIVHGNFNEDSGVIDKPI 189

Query: 116 ICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPI 175
                   K+ +  E G+ + T ++V+E    N + V L   TGR+HQ+RVH+ ++GHPI
Sbjct: 190 YRVGEGTLKRIID-ERGQRSITLFKVIEQYK-NASLVELTLETGRTHQIRVHLSSIGHPI 247

Query: 176 LGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
            GD  Y   E      R  LHA  L I HP  G  +  ++   
Sbjct: 248 YGDSLYG-EEEPQYIDRQALHAYKLQIPHPKDGKILKLESSLP 289


>UniRef50_A8GQ59 Pseudouridine synthase n=15 Tax=Rickettsia RepID=A8GQ59_RICAH
          Length = 329

 Score =  298 bits (765), Expect = 8e-80,   Method: Composition-based stats.
 Identities = 64/237 (27%), Positives = 101/237 (42%), Gaps = 21/237 (8%)

Query: 3   MENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DY 54
            E         L I+Y+DD ++V+NK +G+   PG        V   +            
Sbjct: 68  EELKIAAVNIALDIIYEDDDLIVINKAAGMTVHPGAGHHDDTLVNALLYHTKNLSDIGSA 127

Query: 55  PQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLP 114
            +   VHRLD  T+G++VVA    A   L  Q  +R+  ++Y A VWG  +P  G++   
Sbjct: 128 ARPGIVHRLDKDTTGLMVVAKNNKAHMLLANQIEQRQVIRKYKALVWGVINPLAGVIKNN 187

Query: 115 LICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNT-ARVVLKPITGRSHQLRVHMLALGH 173
           +      R K  +    GK A T Y+ +E     T + V  +  TGR+HQ+RV +  + H
Sbjct: 188 IGRSRVERQKMSILKYGGKEAVTHYKTLELFYGGTISMVECRLNTGRTHQIRVQLSHVKH 247

Query: 174 PILGDRFYASPEARAM------------APRLLLHAEMLTITHPAYGNSMTFKAPAD 218
            ++GD+ Y + + +                R  LH+  L+ THP     M F     
Sbjct: 248 SVVGDQTYGNNDRKIAHSSPALKAKLIDFKRQALHSWYLSFTHPTSNKIMEFSCELP 304


>UniRef50_D0KVM5 Pseudouridine synthase n=11 Tax=Proteobacteria RepID=D0KVM5_HALNC
          Length = 340

 Score =  298 bits (765), Expect = 9e-80,   Method: Composition-based stats.
 Identities = 78/235 (33%), Positives = 111/235 (47%), Gaps = 20/235 (8%)

Query: 1   MGMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRD-----YP 55
           +       PQ+  L I+Y+DD I+V+NK   ++  P         V   +  D      P
Sbjct: 68  IEEAVAAVPQDIPLDIIYEDDAIIVLNKSPDIVVHPAAGNPDGTLVNALLFHDPSLVSVP 127

Query: 56  QAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPL 115
           +A  VHRLD  TSGV+VVA T AA + L      R+ +++Y   V GH     G VD P+
Sbjct: 128 RAGVVHRLDKQTSGVMVVAKTLAAHKILVENLAARKIRREYDTVVMGHVVAG-GTVDAPI 186

Query: 116 ICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPI 175
                +R +Q V   TGK A T Y V+++  +    + ++  TGR+HQ+RVHM  + HP+
Sbjct: 187 GRHPRDRQRQAV-TATGKRAVTHYRVLQHYGEQ-TWLRVQLETGRTHQIRVHMAHIRHPV 244

Query: 176 LGDRFYASPEARAM------------APRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           +GD  Y                      R  LHA  LT+ HP  G  M F+AP  
Sbjct: 245 IGDPVYGGRPRIPPRASTALIDVLRHFERQALHARYLTLAHPVTGTQMRFEAPMP 299


>UniRef50_Q1ILA4 Pseudouridine synthase n=1 Tax=Candidatus Koribacter versatilis
           Ellin345 RepID=Q1ILA4_ACIBL
          Length = 333

 Score =  298 bits (764), Expect = 1e-79,   Method: Composition-based stats.
 Identities = 75/239 (31%), Positives = 116/239 (48%), Gaps = 29/239 (12%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKD----SVMTRIQRDYP--------- 55
           P++  L ++Y+DD + V+NKP+G++   G     ++    +++  +   +          
Sbjct: 77  PEDIPLDVVYEDDDLAVINKPAGMMVHVGAGATEEERNRGTLVNALLYRFRALSEVGGDM 136

Query: 56  QAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPL 115
           +   VHRLD  TSG+IVVA    A R+L  QF  R   K+YVA V G P   +G ++LP+
Sbjct: 137 RPGIVHRLDKETSGLIVVAKNDVAHRKLAEQFSSRRVHKKYVALVHGWPKKLKGTINLPI 196

Query: 116 ICDWPNRPKQKVCYETGKPAQTEYEV---VEYAADNTARVVLKPITGRSHQLRVHMLALG 172
             D   R +       G+ A + YEV   +E      A V +K  TGR+HQ+RVHM +LG
Sbjct: 197 ARDMSRRTRMTTRGSGGRDALSHYEVKEKIESPYGKFALVEVKIETGRTHQIRVHMASLG 256

Query: 173 HPILGDRFYASPEARAM-------------APRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           HP++GD  Y +P    +               R  LHA  + +  PA G ++ F     
Sbjct: 257 HPVVGDTLYGAPGELRVTKALKGMPSKMASLERNFLHAAEIELQQPATGKALRFVTKVP 315


>UniRef50_C9RQF0 Pseudouridine synthase, RluA family n=1 Tax=Fibrobacter
           succinogenes subsp. succinogenes S85 RepID=C9RQF0_FIBSS
          Length = 424

 Score =  297 bits (763), Expect = 1e-79,   Method: Composition-based stats.
 Identities = 75/245 (30%), Positives = 107/245 (43%), Gaps = 29/245 (11%)

Query: 2   GMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------- 52
              +   P++  L I+Y+DD I+V+NKP  L+  PG            +           
Sbjct: 66  KESSTLEPEDIPLNIVYEDDDIVVINKPRNLVVHPGNGVSKGTLAAALLYHFKENLSTVN 125

Query: 53  DYPQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVD 112
              +   VHRLD  T G++VVA   AA R L  Q   R   + Y A VWG P   EG +D
Sbjct: 126 GPLRPGIVHRLDKDTPGLMVVAKNDAAHRHLAHQLETRTLHRTYNALVWGCPRDLEGTID 185

Query: 113 LPLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALG 172
            P+  +  NR K  V  + GK ++T Y V +        + L+  +GR+HQ+RVH    G
Sbjct: 186 APIGRNPKNRLKMAVV-KGGKESRTHY-VAKQFFAIATLLELQLESGRTHQIRVHSRYTG 243

Query: 173 HPILGDRFYASPEA----------------RAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
           HP++GD  Y   +                   +AP  LL A  + + HP     +TFK P
Sbjct: 244 HPVVGDPLYDGRDESLNRVPPLMKPVAEKVLEIAPAQLLQAVKIELIHPRTNKKLTFKVP 303

Query: 217 A--DF 219
               F
Sbjct: 304 MEEPF 308


>UniRef50_C8P3R0 Pseudouridine synthase n=1 Tax=Erysipelothrix rhusiopathiae ATCC
           19414 RepID=C8P3R0_ERYRH
          Length = 308

 Score =  297 bits (763), Expect = 2e-79,   Method: Composition-based stats.
 Identities = 72/226 (31%), Positives = 108/226 (47%), Gaps = 11/226 (4%)

Query: 2   GMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRD-------- 53
             +    P    L I+Y+DD I+VVNKP GL+  P     ++ +++  +           
Sbjct: 71  EEQISIVPVPMDLDIVYEDDAILVVNKPKGLIVHPSPSTLNQPTLVHGLLAHTTQLSDLN 130

Query: 54  -YPQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVD 112
              +   VHR+D  T+G++VVA T  A   L    ++R   ++YVA V          VD
Sbjct: 131 GELRPGIVHRIDKDTTGLLVVAKTNEAHEILVEDLKQRLISREYVAIVHHQFKHQSATVD 190

Query: 113 LPLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALG 172
            P+  D  NR +  V  +  K A T + + E   D  + +  K  TGR+HQ+RVH   + 
Sbjct: 191 APIGRDPKNRQRMAVTDQNSKQAVTHFYLAERFND-FSVLRCKLDTGRTHQIRVHAQYIK 249

Query: 173 HPILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           HPI+GD+ Y S +         LHA+ LT+THP     MTF+A   
Sbjct: 250 HPIVGDQTY-SYKNTWETNGQCLHAQKLTLTHPVSKEVMTFEAELP 294


>UniRef50_B5YKV0 Pseudouridine synthase n=1 Tax=Thermodesulfovibrio yellowstonii DSM
           11347 RepID=B5YKV0_THEYD
          Length = 315

 Score =  297 bits (762), Expect = 2e-79,   Method: Composition-based stats.
 Identities = 67/232 (28%), Positives = 113/232 (48%), Gaps = 16/232 (6%)

Query: 1   MGMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP----- 55
           +       PQ   + ++Y+DD+++V++KP+G++  P         +              
Sbjct: 69  LENSEKLIPQNIPIQVIYKDDYLIVLSKPAGMVVYPCAGHPDGTLMNALAYHVKKLANVG 128

Query: 56  ---QAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVD 112
              +   VHRLD  TSGV+VVAL      +L   F++RE KK+Y+A V+G      G + 
Sbjct: 129 APFRPGIVHRLDKDTSGVMVVALDDETYYKLVEAFKKREIKKEYLALVYGQLR-GSGKIT 187

Query: 113 LPLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALG 172
            P+     +R K  +  +  K A TE+EV++    N   + +K +TGR+HQ+RVH  ++G
Sbjct: 188 TPVGRAIYDRKKMSIKSKKAKEAITEWEVIKNFK-NYTFLKVKILTGRTHQIRVHFSSIG 246

Query: 173 HPILGDRFYASPE------ARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           HP++GD+ Y           +    R +LHA  + + HP     + F+A   
Sbjct: 247 HPVIGDKTYGRKTYIEIGNKKIPVSRQMLHAHKIELIHPITEKLLQFEASLP 298


>UniRef50_Q01Q94 Pseudouridine synthase n=1 Tax=Candidatus Solibacter usitatus
           Ellin6076 RepID=Q01Q94_SOLUE
          Length = 296

 Score =  296 bits (760), Expect = 3e-79,   Method: Composition-based stats.
 Identities = 71/232 (30%), Positives = 116/232 (50%), Gaps = 17/232 (7%)

Query: 1   MGMENYNPP------QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR-- 52
           + +E  +PP      ++  L ILY+D  ++ ++KP+G++   G        V   + R  
Sbjct: 58  VEVEPADPPPLNATAEDIPLRILYEDADVVAIDKPAGMVVHAGAGVHSGTLVNALLHRFA 117

Query: 53  ------DYPQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSP 106
                    +   VHRLD  TSGV++VA   AA ++L  QF  RE +K Y+A V G   P
Sbjct: 118 TLSGVGGPLRPGIVHRLDRFTSGVLLVAKNDAAHQKLAAQFSGREIEKVYLALVHGTVKP 177

Query: 107 AEGLVDLPLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRV 166
             G ++ P+  D  +R +       G+ A +EY V+    D    + ++  TGR+HQ+RV
Sbjct: 178 ETGRIERPIARDPVHRARMTARLAEGRAAWSEYRVLRRFPD-FTLLEVRIGTGRTHQIRV 236

Query: 167 HMLALGHPILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           H+ ++ HP++GD  Y +P A+ +  R  LHA  +    P  G  M  ++P  
Sbjct: 237 HLASIRHPVVGDTLYGAP-AQPLLGRYFLHAHRIRFHLP-SGREMLIESPLP 286


>UniRef50_D1Y3Y9 Pseudouridine synthase n=1 Tax=Pyramidobacter piscolens W5455
           RepID=D1Y3Y9_9BACT
          Length = 345

 Score =  296 bits (759), Expect = 4e-79,   Method: Composition-based stats.
 Identities = 74/219 (33%), Positives = 109/219 (49%), Gaps = 12/219 (5%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP--------QAESVH 61
           Q+    ++Y+DD ++VVNKP+G++  PG        V   + R           +   VH
Sbjct: 112 QDMPFDVVYEDDDVIVVNKPAGVVVHPGAGRPDGTLVNGLMFRYPEIGRIGDSVRPGIVH 171

Query: 62  RLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPN 121
           RLD+ TSG++VVA + AA R L   F+  E  K+Y+    G     EG VD P+  D  N
Sbjct: 172 RLDVGTSGLMVVARSDAAFRGLTEAFQAHEVLKEYLGLGVGALKAPEGTVDAPIGRDPRN 231

Query: 122 RPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFY 181
           R K  V +  G+ A T+Y+V+         + ++  TGR+HQ+RVHM ALG  + GD  Y
Sbjct: 232 RLKMCVSW-DGRDAVTDYKVLWT-RARCNLIRVRLHTGRTHQIRVHMRALGCSLDGDTLY 289

Query: 182 ASPEARAMA--PRLLLHAEMLTITHPAYGNSMTFKAPAD 218
              +        R+ LH+  L   HP  G  + F+AP  
Sbjct: 290 GPKDPAQHILKDRVFLHSWRLGFRHPVSGERLEFRAPLP 328


>UniRef50_C8S0A2 Pseudouridine synthase n=1 Tax=Rhodobacter sp. SW2
           RepID=C8S0A2_9RHOB
          Length = 356

 Score =  295 bits (758), Expect = 5e-79,   Method: Composition-based stats.
 Identities = 70/251 (27%), Positives = 104/251 (41%), Gaps = 40/251 (15%)

Query: 8   PPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR---------DYPQAE 58
            P++  L ++++D  ++VV+KP G++  P         V   +              +  
Sbjct: 93  QPEDIPLTVVWEDADLIVVDKPVGMVVHPAPGSYTGTLVNALLHHCGDTLSGVGGAKRPG 152

Query: 59  SVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPA-------EGL- 110
            VHR+D  TSG++VVA T  A   L  QF      + Y+A V G P+ A        G+ 
Sbjct: 153 IVHRIDKDTSGLLVVAKTDRAHHGLAAQFEAHSVTRHYIALVHGAPNAADPRLRGIRGVS 212

Query: 111 --------VDLPLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADN--TARVVLKPITGR 160
                   +   L     +R +Q V +++G+ A T   V+E        A V     TGR
Sbjct: 213 FEPGGIVCIATNLARHKTDRQRQAVLFDSGRHAVTRVRVLESYGTPPVAALVECWLETGR 272

Query: 161 SHQLRVHMLALGHPILGDRFYASPEARAM-------------APRLLLHAEMLTITHPAY 207
           +HQ+RVHM   GH +LGD+ Y      A               PR  LHA  L   HP  
Sbjct: 273 THQIRVHMSHAGHALLGDQTYGGRRKVAPKAVGEAVAQAANDFPRQALHAASLGFVHPVS 332

Query: 208 GNSMTFKAPAD 218
           G  + F +P  
Sbjct: 333 GEELLFTSPLP 343


>UniRef50_P54604 Uncharacterized RNA pseudouridine synthase yhcT n=5 Tax=Bacillus
           RepID=YHCT_BACSU
          Length = 302

 Score =  295 bits (758), Expect = 5e-79,   Method: Composition-based stats.
 Identities = 65/224 (29%), Positives = 109/224 (48%), Gaps = 11/224 (4%)

Query: 2   GMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP------ 55
              +   P+   L IL++D+H++++NKP+G+ + P    +    +   I   Y       
Sbjct: 71  SEASSVIPEYGELDILFEDNHMLIINKPAGIATHPNEDGQTGT-LANLIAYHYQINGETC 129

Query: 56  QAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPL 115
           +   VHRLD  TSG IV A  + A   L +Q  ++  K+ Y A   G     +G ++ P+
Sbjct: 130 KVRHVHRLDQDTSGAIVFAKHRLAHAILDQQLEKKTLKRTYTAIAEGKLRTKKGTINSPI 189

Query: 116 ICDWPNRPKQKVCYETGKPAQTEYEVVE-YAADNTARVVLKPITGRSHQLRVHMLALGHP 174
             D  +  +++V    G+ A T ++V+   A +  + V L+  TGR+HQ+RVH+ +LGHP
Sbjct: 190 GRDRSHPTRRRV-SPGGQTAVTHFKVMASNAKERLSLVELELETGRTHQIRVHLASLGHP 248

Query: 175 ILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           + GD  Y       +  R  LHA  +   HP     +  +AP  
Sbjct: 249 LTGDSLYGGGS--KLLNRQALHANKVQAVHPITDELIVAEAPFP 290


>UniRef50_B8J173 Pseudouridine synthase, RluA family n=2 Tax=Desulfovibrio
           RepID=B8J173_DESDA
          Length = 525

 Score =  295 bits (758), Expect = 5e-79,   Method: Composition-based stats.
 Identities = 87/227 (38%), Positives = 118/227 (51%), Gaps = 11/227 (4%)

Query: 2   GMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR-------DY 54
              +   P+E  L +L+QDDH++V NKP+GL   P      +  V   + R       + 
Sbjct: 68  EHPDRLQPEEGHLELLWQDDHLVVCNKPAGLTVHPCPSCPEQTLVQRLLGRFPQLSRLEG 127

Query: 55  PQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLP 114
            +   VHRLD  TSG++VVALT+A    L   F ER+  K+Y+A V G   P EG    P
Sbjct: 128 QRPGIVHRLDKDTSGLLVVALTEADCLALAAAFAERQVHKEYLALVSG-LPPLEGQCREP 186

Query: 115 LICDWPNRPKQKVCYET--GKPAQTEYEVVEYAADN-TARVVLKPITGRSHQLRVHMLAL 171
           L      + K  V  E   G+ A TE+  +    D   + + ++  TGR+HQ+RVHM  L
Sbjct: 187 LGRHPTAKIKMAVVPEDQGGRNAFTEWRRLWNTDDGSVSLLAVRIHTGRTHQIRVHMTHL 246

Query: 172 GHPILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           G+P+LGDR YA    + MAPR +LHA  L  THPA G  M F  P  
Sbjct: 247 GYPLLGDRLYAPKAVQNMAPRQMLHAWRLGFTHPASGEDMRFTCPPP 293


>UniRef50_A8ZXZ8 Pseudouridine synthase n=1 Tax=Desulfococcus oleovorans Hxd3
           RepID=A8ZXZ8_DESOH
          Length = 329

 Score =  295 bits (757), Expect = 6e-79,   Method: Composition-based stats.
 Identities = 80/232 (34%), Positives = 114/232 (49%), Gaps = 25/232 (10%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP---------QAES 59
           P+   L +L++D  ++VVNKP GL+  P    E    ++ R+   +P         +   
Sbjct: 77  PEPAPLPLLFEDAFLLVVNKPPGLVVHPAPGHEGGT-LVNRLLHHFPAIGTVGEPDRPGI 135

Query: 60  VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDW 119
           VHRLD  TSG +VVA T AA + L   F+ R+ +K Y+A V+G      G+V LP+    
Sbjct: 136 VHRLDRNTSGALVVAKTAAAHQALSDMFKSRQVRKTYLALVYGQMKSTGGVVTLPIGRHS 195

Query: 120 PNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDR 179
             R K  V     +PA+T ++V +   D  + + L+  TGR+HQ+RVH  AL  P++GD 
Sbjct: 196 LERKKMSVSSPQARPAETRWKVRKAFVD-ASLLELEIHTGRTHQIRVHCTALQRPVVGDP 254

Query: 180 FY--------------ASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPA 217
            Y              AS E    A R +LHA  L   HP  G  M F AP 
Sbjct: 255 TYPCKWTRKRQHFSSRASFELLNAAGRQMLHAWRLEFDHPVTGAPMCFTAPL 306


>UniRef50_A5EX53 Pseudouridine synthase n=1 Tax=Dichelobacter nodosus VCS1703A
           RepID=A5EX53_DICNV
          Length = 322

 Score =  295 bits (757), Expect = 6e-79,   Method: Composition-based stats.
 Identities = 76/226 (33%), Positives = 110/226 (48%), Gaps = 20/226 (8%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR-----DYPQAESVHRLD 64
           Q   L ILY DD I+V+NKP+GL+  P         +   +         P++  VHRLD
Sbjct: 82  QNLPLNILYADDDIIVINKPAGLVVHPAVGNHDNTLLNALLYHFPQTKHLPRSGIVHRLD 141

Query: 65  MATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPK 124
             TSG +V+A +  A  +L RQ + R   + Y+A V+G+ +  +  +DLP+     +R K
Sbjct: 142 KDTSGAMVIAHSARAHTDLVRQLQNRSMGRIYLALVYGYITAGD-TIDLPIGRHAKDRLK 200

Query: 125 QKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASP 184
             V    GKPA T Y + E        + ++  TGR+HQ+RVH+    HP++GD+ Y + 
Sbjct: 201 MAV-RPDGKPAITHYRIEERW-QTLTLLRVQLETGRTHQIRVHLSHHRHPLVGDKLYGAR 258

Query: 185 E------------ARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
                        A A  PR  LHA  L + HPA    M F AP  
Sbjct: 259 PFLASSLTELQRQALAEFPRQALHAVELHLHHPATNEIMRFTAPLP 304


>UniRef50_D1U4S9 Pseudouridine synthase, RluA family n=1 Tax=Desulfovibrio
           aespoeensis Aspo-2 RepID=D1U4S9_9DELT
          Length = 596

 Score =  295 bits (756), Expect = 1e-78,   Method: Composition-based stats.
 Identities = 75/234 (32%), Positives = 112/234 (47%), Gaps = 24/234 (10%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR-----------DYPQAE 58
               L ++++D H+ V++K +GL + P   E     V   + R           D  +  
Sbjct: 95  VPGELEVVFEDAHVAVIDKRAGLTTHPAPGEPGPTLVNHLLHRWPDVASDISGMDRQRPG 154

Query: 59  SVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICD 118
            VHRLD  TSG++VVALT+     L   F  R  +K Y+A V G P+   G +D P+   
Sbjct: 155 IVHRLDKDTSGLMVVALTEGDRLRLAADFAGRRVRKVYLAVVLGRPAQPAGTIDAPMGRH 214

Query: 119 WPNRPKQKVCYETGKPAQTEYEVVEYAADN-TARVVLKPITGRSHQLRVHMLALGHPILG 177
              + +  V    G+ A ++Y V+        + V ++  TGR+HQ+RVHM  +GHP+LG
Sbjct: 215 PSQKTRMAVVARGGREAVSDYRVLWTGPRGLASLVAVRIHTGRTHQIRVHMAHIGHPLLG 274

Query: 178 DRFYASPEA----------RAMAPRLLLHAEMLTITHPAYGNSMTF--KAPADF 219
           D  Y   E             +APR +LHA  L+  HPA    +T   + PADF
Sbjct: 275 DSAYGPRENVEWSRRPDRLAGLAPRQMLHAFHLSFRHPATCERVTLWRRPPADF 328


>UniRef50_C4XFS9 Pseudouridine synthase n=2 Tax=Mycoplasma RepID=C4XFS9_MYCFE
          Length = 315

 Score =  294 bits (755), Expect = 1e-78,   Method: Composition-based stats.
 Identities = 57/224 (25%), Positives = 95/224 (42%), Gaps = 16/224 (7%)

Query: 7   NPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR---------DYPQA 57
             P    L I Y+DD ++++NKPS L+  P     +   V   +              + 
Sbjct: 77  IEPVNIPLDIKYEDDDLVIINKPSNLVVHPSPGHYNDTLVNGLLYHFKNNLSNENGLLRP 136

Query: 58  ESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLIC 117
             VHR+D  TSG++++A        L    +  E ++ Y+A V G        ++LP+  
Sbjct: 137 GIVHRIDKDTSGLLIIAKNNKMHNSLTDMLKRHEIERSYLAIVRGLIENPLTKINLPIAR 196

Query: 118 DWPNRPKQKVCYETGKPAQTEYEVVEYA---ADNTARVVLKPITGRSHQLRVHMLALGHP 174
           +  +R K    ++ GK A T   ++++     +  + V  +  TGR+HQ+RVH+  + HP
Sbjct: 197 NTVDR-KMMSVHKEGKEAITFVHLLKHFYLDKEPMSLVRCELKTGRTHQIRVHLSYIKHP 255

Query: 175 ILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           + GD  Y             LHA  L   HP     +   AP  
Sbjct: 256 VYGDPTYGKSVDEFN---QRLHAYKLKFIHPLTKKEICVYAPVP 296


>UniRef50_C0QAZ3 RluD1 n=1 Tax=Desulfobacterium autotrophicum HRM2
           RepID=C0QAZ3_DESAH
          Length = 313

 Score =  294 bits (754), Expect = 1e-78,   Method: Composition-based stats.
 Identities = 78/229 (34%), Positives = 117/229 (51%), Gaps = 14/229 (6%)

Query: 2   GMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP------ 55
            +E+    +   L  L++D  I+VVNKP+G++  PG        +   +   +P      
Sbjct: 69  EIESKPRAESISLDFLHEDQWIVVVNKPAGMVVHPGAGNSSGTLLNALL-HHFPSLTDTH 127

Query: 56  -----QAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGL 110
                +   VHRLD  TSG IVVA +K A   L+++FR R  +K+Y+A   G  +  +G 
Sbjct: 128 CDPPLRGGIVHRLDKDTSGTIVVAKSKKAYEFLQKEFRFRRVEKRYIALATGIITETQGR 187

Query: 111 VDLPLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLA 170
           + LP+     +R +  V  E  +PA+T + V+   A +   + +   TGR+HQ+RVH  A
Sbjct: 188 ITLPIGRHPIHRKRMAVNTERARPAETLWRVLGQMAGH-TLLDVGLKTGRTHQIRVHFRA 246

Query: 171 LGHPILGDRFYA-SPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           LGHP+ GDR Y    +  A APR +LHA  L   HP  G  + F AP  
Sbjct: 247 LGHPLAGDRVYGFRGKQSARAPRQMLHAGTLGFRHPWSGKRVEFTAPLP 295


>UniRef50_Q8DCG0 Ribosomal large subunit pseudouridine synthase A n=82
           Tax=Proteobacteria RepID=RLUA_VIBVU
          Length = 250

 Score =  294 bits (754), Expect = 2e-78,   Method: Composition-based stats.
 Identities = 122/223 (54%), Positives = 151/223 (67%), Gaps = 4/223 (1%)

Query: 1   MGMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESV 60
           M M  Y PP +PW  I+++DDHI+ VNKPSGLLSVPGRL EH DS+ +R+Q  YP+ + V
Sbjct: 1   MAMLEYLPPTDPWTEIIFEDDHILAVNKPSGLLSVPGRLPEHHDSMWSRLQEQYPEIQVV 60

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLDM+TSG++V A  K AE  LK+QF+ R   K Y ARVWGH     G++DLPLICDWP
Sbjct: 61  HRLDMSTSGLMVFAKNKRAEAALKKQFQYRLTHKVYYARVWGHVEADSGMIDLPLICDWP 120

Query: 121 NRPKQKVCYETGKPAQTEYEVVEY----AADNTARVVLKPITGRSHQLRVHMLALGHPIL 176
           NRP QKVC+E GKP+QT ++V +         T  + L P+TGRSHQLRVHM ALGHPI+
Sbjct: 121 NRPMQKVCHEHGKPSQTAFQVAKREVHANGAQTTIMRLLPVTGRSHQLRVHMQALGHPIV 180

Query: 177 GDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
           GD FYA  +A   + RL LHA  L+  HP      +   P DF
Sbjct: 181 GDEFYAQGDAFTFSERLELHAAELSFYHPKSHWLRSLFVPCDF 223


>UniRef50_B2RIT5 Pseudouridine synthase n=80 Tax=root RepID=B2RIT5_PORG3
          Length = 365

 Score =  294 bits (754), Expect = 2e-78,   Method: Composition-based stats.
 Identities = 70/240 (29%), Positives = 103/240 (42%), Gaps = 29/240 (12%)

Query: 7   NPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQA--------- 57
             P++  L I+Y+DD ++V+NKP+GL+  PG        V                    
Sbjct: 103 IIPEDIPLDIVYEDDVLLVINKPAGLVVHPGHGNYTGTLVNALAYYLREDPEYDPMDPSL 162

Query: 58  ESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLIC 117
             VHR+D  TSG++VVA    A+ +L +QF  +   + Y A VWG      G +   +  
Sbjct: 163 GLVHRIDKDTSGLLVVAKRAEAKSDLCKQFYYKTTHRSYRALVWGRFDYPIGTITGNIGR 222

Query: 118 DWPNRPKQKVCYET---GKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHP 174
           D  +R +  V       GKPA T Y+V+E  A   + +  +  TGR+HQ+R HM  +GH 
Sbjct: 223 DLKDRLQMAVFPPDGDIGKPAVTHYQVLEELA-YVSWIECRLETGRTHQIRAHMKHIGHT 281

Query: 175 ILGDRFYASPEARAM----------------APRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           +  D  Y   +                     PR  LHA+ L   HP  G  M F +   
Sbjct: 282 LFADERYGGDQILRGNNTANYRRFVQNCLAICPRQALHAKTLGFRHPVTGVEMQFDSDIP 341


>UniRef50_Q6MEC0 Pseudouridine synthase n=1 Tax=Candidatus Protochlamydia
           amoebophila UWE25 RepID=Q6MEC0_PARUW
          Length = 318

 Score =  293 bits (753), Expect = 2e-78,   Method: Composition-based stats.
 Identities = 72/225 (32%), Positives = 108/225 (48%), Gaps = 14/225 (6%)

Query: 4   ENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYP 55
           E+   P+   L ILY+D+H++V+NKP+G++  P         V   +          D  
Sbjct: 77  ESNLMPENIPLSILYEDEHLLVINKPAGMVVHPAPGNWSGTFVNALLYYCQKLPLLPDTI 136

Query: 56  QAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPL 115
           +   VHRLD  TSG++V A T   +++L   F  R+  K Y+A   G P+   G +  P+
Sbjct: 137 RPGIVHRLDKGTSGLLVAAKTLETQQKLIELFASRKVYKAYLAICIGRPAD--GEIQAPI 194

Query: 116 ICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPI 175
                +R +  V   TGKPA +  + +   +D  + V ++  TGR+HQ+RVHM   G PI
Sbjct: 195 GRHPIHRKQMAVI-PTGKPAISFCKTLG-WSDKLSFVQIEIATGRTHQIRVHMKYRGSPI 252

Query: 176 LGDRFYASPEARAM--APRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           LGD  Y           P  LLHA +L   HP    ++ F  P  
Sbjct: 253 LGDPLYGQISLNQYYSVPHQLLHAAVLRFQHPISLENLEFCTPPP 297


>UniRef50_O67638 Uncharacterized RNA pseudouridine synthase aq_1758 n=3
           Tax=Aquificaceae RepID=Y1758_AQUAE
          Length = 316

 Score =  293 bits (753), Expect = 2e-78,   Method: Composition-based stats.
 Identities = 73/228 (32%), Positives = 104/228 (45%), Gaps = 17/228 (7%)

Query: 7   NPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYPQAE 58
             P+   + I+Y+D+ I VV KP GL+  P         V   +             +  
Sbjct: 75  VKPENIPINIIYEDEDIAVVEKPCGLVVHPSPGYTSGTLVNALLYHIKDLSSIGGVERPG 134

Query: 59  SVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICD 118
            VHRLD  T+GV+V+A    A R L RQF+ER+ +K Y   V G      G +D P+   
Sbjct: 135 IVHRLDKETAGVMVIAKNNTAHRNLVRQFQERKTEKFYKVLVKGLVKKDYGAIDTPIARH 194

Query: 119 WPNRPKQKVCYETGKPAQTEYEVVEYAAD-NTARVVLKPITGRSHQLRVHMLALGHPILG 177
             +R +  V  + GK A TEY V++         + +K  TGR+HQ+RVH  ++GHP+LG
Sbjct: 195 PVDRKRFWV-RKEGKEALTEYWVLKRYEKYEITLLKVKIHTGRTHQIRVHFASIGHPVLG 253

Query: 178 DRFYASPEARAMAPRL-------LLHAEMLTITHPAYGNSMTFKAPAD 218
           DR Y    +      L       +L A  L   HP  G  M F+    
Sbjct: 254 DRTYGFKSSSVPKELLSLMGECNMLIAYHLGFYHPTKGEWMVFEIEEP 301


>UniRef50_A9CFZ5 Pseudouridine synthase n=3 Tax=Rhizobiales RepID=A9CFZ5_AGRT5
          Length = 222

 Score =  293 bits (753), Expect = 2e-78,   Method: Composition-based stats.
 Identities = 108/214 (50%), Positives = 148/214 (69%), Gaps = 1/214 (0%)

Query: 6   YNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDM 65
           YNPP +PWL I+++DD ++V++KPSGLLSVPGR     DS+MTR+Q+ +P+A  ++RLD 
Sbjct: 10  YNPPLDPWLTIVHRDDDLLVLDKPSGLLSVPGRDPALSDSLMTRVQKQFPKALMINRLDK 69

Query: 66  ATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQ 125
            TSG+++++L + A   +  QF +RE +K YVA VWG  +  EG VDLPL  D  N+P+ 
Sbjct: 70  DTSGIVLMSLNRKAHAAIAAQFEKRETRKSYVAIVWGTVAGEEGEVDLPLAIDPDNKPRH 129

Query: 126 KVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPE 185
           +V +E GKPAQ+ + V+E       R+ L P+TGR+HQLRVHM ALGHPILGD FYA  E
Sbjct: 130 RVDHENGKPAQSLWRVLERLPLPATRLALTPLTGRTHQLRVHMKALGHPILGDEFYAEGE 189

Query: 186 ARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
           A   APRL+LHA+ +   HP  G  +T+  P  F
Sbjct: 190 ALTAAPRLMLHAQEVGFRHP-DGRDVTYTVPCPF 222


>UniRef50_Q03WF6 Pseudouridine synthase n=9 Tax=Firmicutes RepID=Q03WF6_LEUMM
          Length = 312

 Score =  293 bits (753), Expect = 2e-78,   Method: Composition-based stats.
 Identities = 61/203 (30%), Positives = 97/203 (47%), Gaps = 11/203 (5%)

Query: 25  VVNKPSGLLSVPGRLEEHKDSVMTRIQR-------DYPQAESVHRLDMATSGVIVVALTK 77
           VVNKP G++  P         V   +            +   VHR+D  TSG+++VA   
Sbjct: 90  VVNKPQGMVVHPAAGHSSGTLVNALLHHSPLSTINGEFRPGIVHRIDRDTSGLLMVAKND 149

Query: 78  AAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYETGKPAQT 137
            A R L  Q +  + ++ Y A V G  +   G ++ P+     +R KQ V  E G+ A T
Sbjct: 150 KAHRSLSEQLKSHKNQRVYYALVRGEFTEDSGTIEAPIGRHKIDRKKQAVI-EGGREAVT 208

Query: 138 EYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARAM--APRLLL 195
            + V++        + +   TGR+HQ+RVHM  +GHP++GD  Y + +          LL
Sbjct: 209 HFRVLKRYV-GYTLLKVSLETGRTHQIRVHMSYIGHPVVGDPVYGTAQKLDGTQLNGQLL 267

Query: 196 HAEMLTITHPAYGNSMTFKAPAD 218
           HA+ LT+  P  G+ ++F +P  
Sbjct: 268 HAKTLTLEQPTTGDELSFDSPLP 290


>UniRef50_Q4FN11 Pseudouridine synthase n=4 Tax=Bacteria RepID=Q4FN11_PELUB
          Length = 326

 Score =  293 bits (751), Expect = 4e-78,   Method: Composition-based stats.
 Identities = 67/243 (27%), Positives = 103/243 (42%), Gaps = 31/243 (12%)

Query: 4   ENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR---------DY 54
           E    P    L I+Y+DD ++++NKP+G++  PG     +  V   +           D 
Sbjct: 72  EASLKPYNFKLQIVYEDDDLLIINKPAGIIMHPGAGNYDETIVNALMHYNKDSLSTIGDE 131

Query: 55  PQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLP 114
            +   VHR+D  TSG+IV+A        L  QF E    + Y   +WG   P+ G +D  
Sbjct: 132 LRPGIVHRIDKDTSGLIVIAKNNETHENLSHQFSEHTITRVYQLLIWGKLRPSSGKIDTF 191

Query: 115 LICDWPNRPKQKVCYETGKPAQTEYEVVEYAADN----TARVVLKPITGRSHQLRVHMLA 170
           +     NR   +V    GK A T Y+ +E   ++     + V  +  TGR+HQ+RVHM  
Sbjct: 192 ITRSSKNRQMMEVSNSKGKRAITNYKTIEIFENDKTPTLSLVECRLETGRTHQIRVHMTH 251

Query: 171 LGHPILGDRFYASPEAR---------------AMAPRLLLHAEMLTITHPAYGNSMTFKA 215
           +G+ I+GD      + +                   R  LHA+ L   HP     M F +
Sbjct: 252 MGNSIMGD---GKYKKKYKKLKNIDTNLENLIYKLDRQFLHAQTLGFIHPRTNEEMVFTS 308

Query: 216 PAD 218
              
Sbjct: 309 ILP 311


>UniRef50_C4XSN0 Ribosomal large subunit pseudouridine synthase D/dephospho-CoA
           kinase n=1 Tax=Desulfovibrio magneticus RS-1
           RepID=C4XSN0_DESMR
          Length = 554

 Score =  292 bits (750), Expect = 4e-78,   Method: Composition-based stats.
 Identities = 74/228 (32%), Positives = 121/228 (53%), Gaps = 20/228 (8%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP--------QAESVH 61
           ++  L +LY D  ++V+NKP+GL   P   +     ++ R+   +P        +   VH
Sbjct: 89  EDGELKLLYLDGDVLVLNKPAGLTIHPASSQPDGT-LVNRLLHHFPDMRAMAGDRPGIVH 147

Query: 62  RLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPN 121
           RLD  TSG+++VA T++A   L   F ER   K Y+A V G P  ++G+++LP+  D  +
Sbjct: 148 RLDKDTSGLLLVAQTESARLALAADFAERRVAKTYLALVHGRPERSDGVIELPVGRDPKH 207

Query: 122 RPKQKVCYETGKPAQTEYEVVEYAADNT-ARVVLKPITGRSHQLRVHMLALGHPILGDRF 180
             K  V  + G+ A++ +++   A D T + + +   TGR+HQ+RVHM A+GHPI+GD  
Sbjct: 208 PTKMAVVAKGGREAKSSWKLAWTAPDGTASLLEVAIATGRTHQIRVHMAAMGHPIVGDAV 267

Query: 181 YASPEAR----------AMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           Y + +             +A R +LHA  L  +HP  G  ++F  P  
Sbjct: 268 YGARQHSDWTRRGGAMARLAKRQMLHAWKLAFSHPGTGEELSFCQPPP 315


>UniRef50_C1FEQ4 Predicted protein n=2 Tax=Micromonas RepID=C1FEQ4_9CHLO
          Length = 357

 Score =  292 bits (750), Expect = 4e-78,   Method: Composition-based stats.
 Identities = 77/250 (30%), Positives = 117/250 (46%), Gaps = 39/250 (15%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR---------------D 53
           P+   L ++++DDH++VVNKP G++  P         V   +                 D
Sbjct: 98  PENIPLDVVFEDDHLVVVNKPPGMVVHPSAGHAGGSLVNALLFHCNERSNRGDDASKMID 157

Query: 54  YPQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDL 113
            P+   VHR+D  TSG++V+A   AA+  L+ QF  R  +++Y+A V G P+   G +D 
Sbjct: 158 VPRLGVVHRIDKGTSGLLVMAKDAAAQAGLQTQFANRSVRRRYLAIVLGTPARESGRIDA 217

Query: 114 PLICDWPNRPKQKVCY-ETGKPAQTEYEVVEYA-ADNTARVVLKPITGRSHQLRVHMLAL 171
           P+  D  +R K  +    TG+ A + + V       N + V  +  TGR+HQ+RVH   +
Sbjct: 218 PIGRDPADRLKMAIVRGATGRQAISNFGVRARLVRGNASLVEWQLETGRTHQIRVHAREM 277

Query: 172 GHPILGDRFY--------------------ASPEARAMAPRLLLHAEMLTITHPAYGNSM 211
           GHPI+GD  Y                    A+ E  A   R +LHA  L   HP  G  +
Sbjct: 278 GHPIVGDEAYGGGGSAAAEFLRRDGAMSAAAAREIVAKCARPMLHARSLGFRHPVTGEEI 337

Query: 212 TF--KAPADF 219
           +F  + P DF
Sbjct: 338 SFAVEPPPDF 347


>UniRef50_Q13E92 Pseudouridine synthase n=28 Tax=Alphaproteobacteria
           RepID=Q13E92_RHOPS
          Length = 426

 Score =  292 bits (750), Expect = 5e-78,   Method: Composition-based stats.
 Identities = 70/240 (29%), Positives = 108/240 (45%), Gaps = 32/240 (13%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR---------DYPQAESV 60
           +   L I+++DD I+V++KP GL+  P    E    V   I              +   V
Sbjct: 174 EAIALEIVHEDDDIIVIDKPRGLVVHPAAGHETGTLVNALIAHCGESLSGIGGVRRPGIV 233

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFRER----EPKKQYVARVWGHPSPAEGLVDLPLI 116
           HRLD  T+G++V A    A + L  QF +     E ++ Y A VWG P+   G +D P+ 
Sbjct: 234 HRLDKDTTGLMVAAKNDRAHQSLSAQFADHGRTGELRRGYYAFVWGAPNRIRGTIDAPID 293

Query: 117 CDWPNRPKQKVCYETGKPAQTEYEVVEYAADN-----TARVVLKPITGRSHQLRVHMLAL 171
                R K  V  + G+ A T +EV+E           + +  +  TGR+HQ+RVH+  +
Sbjct: 294 RHPHAREKMAV-RDGGREAITHWEVLETFTGRSGGEIVSLIACQLETGRTHQIRVHLAHI 352

Query: 172 GHPILGDRFYAS-------------PEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           GHP+LGD  Y                 A     R  LHA +L + HP+ G  + +++   
Sbjct: 353 GHPLLGDDVYGPHFKTKASQLRPDARAALTDLGRQALHAYLLVLEHPSTGEVVAWESGLP 412


>UniRef50_C0QPR5 Pseudouridine synthase n=4 Tax=Hydrogenothermaceae
           RepID=C0QPR5_PERMH
          Length = 319

 Score =  292 bits (749), Expect = 6e-78,   Method: Composition-based stats.
 Identities = 67/227 (29%), Positives = 109/227 (48%), Gaps = 19/227 (8%)

Query: 7   NPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYPQAE 58
             P+   + IL++D+ I VV KP+G++  P         V   +             +A 
Sbjct: 78  IKPENIPVDILFEDEDIAVVYKPAGMVVHPSPGHTSGTLVNALLYHFRNISEYGGKERAG 137

Query: 59  SVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICD 118
            VHRLD  T+G++++A ++ A +EL++QF+ER   K+Y+A V G      G +DLP+   
Sbjct: 138 IVHRLDKDTAGLMIIAKSEFAHKELQKQFQERTVDKRYIAVVTGIVQNDHGFIDLPIGRS 197

Query: 119 WPNRPKQKVCYETGKPAQTEYEVVEYA-ADNTARVVLKPITGRSHQLRVHMLALGHPILG 177
             NR K        + A TEY V   +  +N   V +K  TGR+HQ+RVH  A+GHP+  
Sbjct: 198 IYNRKKMGTEATNLRDALTEYWVKNRSEKENLTVVDIKLHTGRTHQIRVHFSAIGHPLFN 257

Query: 178 DRFYASPEARAMAPRL----------LLHAEMLTITHPAYGNSMTFK 214
           D+ Y   +++  + ++           L A  +   HP  G  +   
Sbjct: 258 DKVYGFKKSQLRSEKMRSISDQTLYHALLAYRIAFDHPRTGEKIDIT 304


>UniRef50_D0J9U5 Pseudouridine synthase n=2 Tax=Blattabacterium RepID=D0J9U5_BLASP
          Length = 344

 Score =  292 bits (749), Expect = 6e-78,   Method: Composition-based stats.
 Identities = 69/258 (26%), Positives = 114/258 (44%), Gaps = 42/258 (16%)

Query: 1   MGMENYNPP-----------QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTR 49
           +  E Y PP           +   L ILY+D+ I+V+NK +G++  PG   E    ++  
Sbjct: 63  VEAEIYYPPILDSEYKNIIAENIPLNILYEDEDILVINKAAGMVVHPGFGNEKGT-LIHG 121

Query: 50  IQRDYP------QAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGH 103
           I+  +       +   VHR+D  T+G++V+A  + A++ L +QF  +  +++Y+A VWG+
Sbjct: 122 IKYHFKNNHQLYRLGLVHRIDKDTTGLLVLAKNEYAQKYLFQQFISKTIQRKYLALVWGN 181

Query: 104 PSPAEGLVDLPLICDWPNRPKQKVCYET---GKPAQTEYEVVEYAADNTARVVLKPITGR 160
               EG +   +  D  NR +  +        + + T Y+V+E        V     TG+
Sbjct: 182 IQKQEGTISGFIGRDPNNRKRMTLFQRNFYRSRYSVTHYKVLERFK-YLTYVSCNLETGK 240

Query: 161 SHQLRVHMLALGHPILGDRFYAS-----------------PEARAMAPRLLLHAEMLTIT 203
           +HQ+RVH   LGHP+  D  Y                    ++  +  R  LHA  L+  
Sbjct: 241 THQIRVHFKYLGHPLFNDSTYGGDKIFMKKYLSKKSIDFFKDSLNLLKRQALHAGSLSFI 300

Query: 204 HPAYGNSMTFKA--PADF 219
           HP       F    P DF
Sbjct: 301 HPK-NRKCHFTCSIPEDF 317


>UniRef50_C0ZH07 Pseudouridine synthase n=1 Tax=Brevibacillus brevis NBRC 100599
           RepID=C0ZH07_BREBN
          Length = 306

 Score =  292 bits (748), Expect = 7e-78,   Method: Composition-based stats.
 Identities = 63/214 (29%), Positives = 105/214 (49%), Gaps = 11/214 (5%)

Query: 11  EPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ------AESVHRLD 64
           +  L I Y+D+ +MV+ KP+GL+  P         +   +   + +        +V+RLD
Sbjct: 78  DMPLSIRYEDEDLMVIAKPAGLVVHPTGNHPSGT-LANGMIAYWKKRGENRKFRAVNRLD 136

Query: 65  MATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPK 124
             TSG+++VA  + A  +  R  + R  ++ Y A V G     +G ++ P+     +   
Sbjct: 137 KDTSGLMIVAKNQWAHEQFSRMQQIRTLQRTYRAIVQGIVESDDGTINTPIGLAENSFIT 196

Query: 125 QKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASP 184
           ++V    G+ A T Y V+    +  + V +K  TGR+HQ+RVHM + GHP+ GD  Y   
Sbjct: 197 RQV-RPDGQTAVTHYRVLAR-GEGMSFVEVKLETGRTHQIRVHMSSEGHPLAGDDLYGG- 253

Query: 185 EARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
             R    R  LHA  L+  HP  G +M+++ P  
Sbjct: 254 -EREHIGRQALHAWGLSFVHPRSGLAMSWEEPLP 286


>UniRef50_B0VJ94 Pseudouridine synthase n=1 Tax=Candidatus Cloacamonas
           acidaminovorans RepID=B0VJ94_9BACT
          Length = 351

 Score =  292 bits (748), Expect = 8e-78,   Method: Composition-based stats.
 Identities = 69/242 (28%), Positives = 103/242 (42%), Gaps = 28/242 (11%)

Query: 3   MENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR---------D 53
                 PQ+  L ++Y+D+++ ++NK +G++  PG        V   + R         +
Sbjct: 78  EPMNVLPQDIPLDVVYEDEYLAIINKKAGMIVHPGFGNPEGTLVNAILYRFGENLSSGKE 137

Query: 54  YPQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDL 113
           + +   VHRLD  TSG+I++A       +L   F  RE KK Y A   G P P +G ++ 
Sbjct: 138 FNRPGIVHRLDRGTSGLIIIAKNDLTHAKLSDMFARREIKKTYFAITTGIPEPEKGEIET 197

Query: 114 PLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGH 173
            L     N     V  E G+ A T Y+ ++      A V + P TGR HQ+RVH   + +
Sbjct: 198 YLARSNKNPRTICVTNE-GRYALTHYKTIKTW-HYFALVEINPATGRMHQIRVHFAHIRY 255

Query: 174 PILGDRFYASPEARA-----------------MAPRLLLHAEMLTITHPAYGNSMTFKAP 216
           PILGD  Y S                         R  LH+  L   HP  G  ++  AP
Sbjct: 256 PILGDLLYNSRRYVQSLVPQNMKKKVTELLVNHLRRQALHSWKLEFFHPITGYPISVSAP 315

Query: 217 AD 218
             
Sbjct: 316 IP 317


>UniRef50_C1SM47 Pseudouridine synthase n=1 Tax=Denitrovibrio acetiphilus DSM 12809
           RepID=C1SM47_9BACT
          Length = 302

 Score =  291 bits (747), Expect = 1e-77,   Method: Composition-based stats.
 Identities = 61/219 (27%), Positives = 104/219 (47%), Gaps = 9/219 (4%)

Query: 7   NPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR------DYPQAESV 60
             P +  + I+Y  D   V+NKP+G+   P         V   +        +  +   V
Sbjct: 74  LTPVKMDIEIIYDCDEFAVINKPAGITVHPAPGHADDTIVNAMLAEFDITDDNDLRPGIV 133

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLD  TSG+++VA  + +   L + F +R+  K+Y+A  WG P   E  ++ P+   + 
Sbjct: 134 HRLDKDTSGLMIVAKNRKSREVLSKVFADRDIDKRYLAVCWGKPKELEFTIEQPIGRHYK 193

Query: 121 NRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRF 180
           +R +  V  E G+ +++   V++   +N     ++  TGR+HQ+RVHM   G P+ GD  
Sbjct: 194 DRKRMCV-REDGRYSKSGVRVLKQN-NNAFLAEIRIFTGRTHQIRVHMSHAGFPLAGDVV 251

Query: 181 YASPEA-RAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           Y   ++ +    R  LH+  L    P  G  M F++P  
Sbjct: 252 YGHRQSLKLPIKRQALHSFRLAFVSPFTGEDMVFESPLP 290


>UniRef50_Q1Q689 Similar to ribosomal large subunit pseudouridine synthase D n=1
           Tax=Candidatus Kuenenia stuttgartiensis
           RepID=Q1Q689_9BACT
          Length = 335

 Score =  291 bits (746), Expect = 1e-77,   Method: Composition-based stats.
 Identities = 72/237 (30%), Positives = 111/237 (46%), Gaps = 24/237 (10%)

Query: 1   MGMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR-------- 52
           +  E    P++  L I+Y+DD++M++NKP  ++  P         V              
Sbjct: 78  VPEETKITPEDIPLNIIYEDDYLMLINKPYDMVVHPAGGHPSGTLVNAVTFYCQNLSQIN 137

Query: 53  DYPQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVD 112
              +A  VHRLD  TSGV++V  + A    +  QF +R  KK+Y A V G  +     ++
Sbjct: 138 GPLKAGIVHRLDRDTSGVMLVIKSDAVHSHIAMQFEKRLVKKEYFAVVEGEVAFDSNEIN 197

Query: 113 LPLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALG 172
           +P+     +R K  V  +TGK A + YEV+E        V + P TGR+HQ+RVHM A+G
Sbjct: 198 MPIGRHRVDRQKMAVRRDTGKNATSVYEVIERFR-GYTLVKIMPKTGRTHQIRVHMQAIG 256

Query: 173 HPILGDRFYAS---------------PEARAMAPRLLLHAEMLTITHPAYGNSMTFK 214
           HP++ D  Y+                P+  ++  R  LHA  +   HP     M F+
Sbjct: 257 HPVVADEMYSKYNACFRSDLLGKERAPDEGSIIERQALHAHRIEFFHPILNKQMAFQ 313


>UniRef50_C6LL16 Pseudouridine synthase n=3 Tax=Clostridiales RepID=C6LL16_9FIRM
          Length = 313

 Score =  290 bits (745), Expect = 2e-77,   Method: Composition-based stats.
 Identities = 65/222 (29%), Positives = 108/222 (48%), Gaps = 11/222 (4%)

Query: 4   ENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP---QAES- 59
                P    L I+Y+D+ ++V++KP+ +   P  +    +++   +   Y    +A   
Sbjct: 75  SENIVPVPMKLDIVYEDEDLLVIDKPADMPVHPS-IHNFDNTLANGLAYYYESRGEAFVY 133

Query: 60  --VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLIC 117
             + RLD  T+G+++VA    +   L    + RE  ++Y+A V G  + AEG VD P+  
Sbjct: 134 RCITRLDRDTTGLLLVAKNMLSGAFLAEMGKRREIHREYLAIVTGK-TEAEGTVDAPIAR 192

Query: 118 DWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILG 177
              +  ++ V ++ G+ A T Y  +EY  D  + V LK  TGR+HQ+RVHM  +GHP+ G
Sbjct: 193 VEGSVLERCVDFQRGERAVTHYRTLEY-RDGYSLVRLKLETGRTHQIRVHMKYIGHPLTG 251

Query: 178 DRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
           D  Y       +     LH+  L   HP  G  M F +   +
Sbjct: 252 DFLYNPD--YRLMDHQALHSHYLAFRHPITGERMEFTSQPPW 291


>UniRef50_C6CWL6 Pseudouridine synthase n=2 Tax=Paenibacillus RepID=C6CWL6_PAESJ
          Length = 316

 Score =  290 bits (745), Expect = 2e-77,   Method: Composition-based stats.
 Identities = 74/232 (31%), Positives = 114/232 (49%), Gaps = 16/232 (6%)

Query: 1   MGME--NYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP--- 55
           M  E      PQ+  L I+++DD+++VVNKP+G++  P +     +++   I   +    
Sbjct: 74  MEEEISEDILPQDLPLSIVFEDDYLLVVNKPAGIIVHPTKGHYT-NTLANGIVHHWQVRG 132

Query: 56  ---QAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVD 112
              +   VHRLD  TSG++V+A      ++L  Q +     K Y A V+G PSPA+G V 
Sbjct: 133 ERVRFRPVHRLDEDTSGLVVIAKNPYIHQQLSEQLQAGTIMKIYCAYVYGTPSPADGTVG 192

Query: 113 LPLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADN-TARVVLKPITGRSHQLRVHMLAL 171
            P+  +  + P  ++    G P+ T Y+          ++V LK  TGR+HQ+RVHM  +
Sbjct: 193 APIDRNPED-PHVRIVTPEGYPSVTHYKTAAVFGGGQASKVRLKLETGRTHQIRVHMKHI 251

Query: 172 GHPILGDRFYA-----SPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           G P++GD  Y        E    A R  LHAE L +THP       + A   
Sbjct: 252 GCPLIGDGMYGLQTGKVDEWETAAGRQALHAETLGLTHPMTKEWSEWTAALP 303


>UniRef50_C7LWM1 Pseudouridine synthase, RluA family n=1 Tax=Desulfomicrobium
           baculatum DSM 4028 RepID=C7LWM1_DESBD
          Length = 526

 Score =  290 bits (744), Expect = 2e-77,   Method: Composition-based stats.
 Identities = 80/224 (35%), Positives = 118/224 (52%), Gaps = 11/224 (4%)

Query: 4   ENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP-------- 55
           ++   P +  L + + D+ ++VVNK   +   P         ++ R+   +P        
Sbjct: 72  DSSVVPDDGPLNVFFADEDLVVVNKTPAMTVHPAPSVAEPT-LVHRVAHHFPALLSQSGE 130

Query: 56  QAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPL 115
           +   VHRLD  TSG+IV+AL+++A   L + F  RE  K+Y+A V G P    G V L L
Sbjct: 131 RPGIVHRLDKDTSGLIVLALSESARLSLTQAFASREVYKEYLALVAGVPDS-SGTVSLAL 189

Query: 116 ICDWPNRPKQKVCYETGKPAQTEYEVVEYAADN-TARVVLKPITGRSHQLRVHMLALGHP 174
                 + +  V    G+ A+T +E++  AAD   + V ++ +TGR+HQ+RVHM ALGHP
Sbjct: 190 GRHPSIKTRMAVVERGGRAAETRFELLWSAADRSASLVRVRIMTGRTHQIRVHMAALGHP 249

Query: 175 ILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           +LGD  YA  +  A APR +LHA  L   HP    SM F AP  
Sbjct: 250 LLGDAVYADKQTAARAPRQMLHAWQLRFEHPRSFESMEFCAPPP 293


>UniRef50_C1A885 Pseudouridine synthase n=1 Tax=Gemmatimonas aurantiaca T-27
           RepID=C1A885_GEMAT
          Length = 329

 Score =  290 bits (743), Expect = 3e-77,   Method: Composition-based stats.
 Identities = 67/221 (30%), Positives = 113/221 (51%), Gaps = 14/221 (6%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP--------QAESVH 61
           ++  L ++Y+D+H++VV+K +G++  P         V   + R  P        +A  VH
Sbjct: 79  EQIPLDVVYEDEHLLVVDKAAGMVVHPAPGNWTGTLVNALLGRGEPLAEGGGEDRAGLVH 138

Query: 62  RLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPN 121
           RLD  TSG++VVA + AA R L      R+  ++Y A  WGH +     V+ P+  D  +
Sbjct: 139 RLDKDTSGLLVVAKSDAAHRTLSSALAARQVTRRYAAVCWGHLAEERITVEKPIARDPRD 198

Query: 122 RPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFY 181
           R +  +  ++GK ++T++  +    D+   +     TGR+HQ+RVH+ + GHP++GD  Y
Sbjct: 199 RTRMAIV-QSGKASRTDFTRLARF-DSVDLLRAHLHTGRTHQIRVHLASTGHPVVGDDTY 256

Query: 182 ASPEARAMA----PRLLLHAEMLTITHPAYGNSMTFKAPAD 218
                R +A     R  LHA  L   HP  G+ +  ++P  
Sbjct: 257 GGGGGRRLALLPPRRHFLHAAWLRFRHPISGDLIDLRSPLP 297


>UniRef50_Q0BWH2 Pseudouridine synthase n=3 Tax=Alphaproteobacteria
           RepID=Q0BWH2_HYPNA
          Length = 341

 Score =  290 bits (743), Expect = 3e-77,   Method: Composition-based stats.
 Identities = 65/251 (25%), Positives = 99/251 (39%), Gaps = 40/251 (15%)

Query: 8   PPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR---------DYPQAE 58
             +   L IL++D H++++NK +G+   P    +    V   +              +  
Sbjct: 75  EAEAIPLEILFEDAHLVILNKAAGMAVHPAPGSQTGTLVNALLHHCQGQLSGIGGVERPG 134

Query: 59  SVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICD 118
            VHRLD  TSGV+V A T++A   L   F   +  + Y A   G P P  G ++  +   
Sbjct: 135 IVHRLDKLTSGVMVAAKTESAHTGLAALFERHDIDRVYRAVTRGAPRPLSGTIEAAIARS 194

Query: 119 WPNRPKQKV----CYETGKPAQTEYEVVEYAADN--------TARVVLKPITGRSHQLRV 166
             +R K  V         + A T Y+ VE              A +  +  TGR+HQ+RV
Sbjct: 195 ESDRKKMSVHRNPDSPAARHAVTHYKAVETFGYKDRATRLPAAALLECRLETGRTHQIRV 254

Query: 167 HMLALGHPILGDRFYASP-------------------EARAMAPRLLLHAEMLTITHPAY 207
           HM   G P++GD  Y                       A     R  LHA +L   HP  
Sbjct: 255 HMAHSGAPLIGDPVYGRQAGIMAWKAPGSEARYDKALAAARAFSRQALHAAVLGFVHPIT 314

Query: 208 GNSMTFKAPAD 218
           G ++ ++AP  
Sbjct: 315 GETLRYEAPLP 325


>UniRef50_A7K2Y9 Pseudouridine synthase n=4 Tax=Vibrio RepID=A7K2Y9_VIBSE
          Length = 250

 Score =  290 bits (743), Expect = 3e-77,   Method: Composition-based stats.
 Identities = 121/223 (54%), Positives = 159/223 (71%), Gaps = 4/223 (1%)

Query: 1   MGMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESV 60
           M M  Y PP +PW+ I+++DD I+ VNKPSGLLSVPGRL EH DS+ +R++  +P+ + V
Sbjct: 1   MAMLEYTPPTDPWVDIVFEDDDILAVNKPSGLLSVPGRLAEHYDSMWSRLKEVHPEIQVV 60

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLDM+TSG++++A  K +ER LK+QF+ R   K Y ARVWGH  P EG +DLPLICDWP
Sbjct: 61  HRLDMSTSGLMLLAKNKPSERALKKQFQYRLTHKVYYARVWGHVEPQEGNIDLPLICDWP 120

Query: 121 NRPKQKVCYETGKPAQTEYEVVEY----AADNTARVVLKPITGRSHQLRVHMLALGHPIL 176
           NRP+QKVC++ GKP+QT ++VV+        +T  V L PITGRSHQLRVH++A+GH I+
Sbjct: 121 NRPRQKVCFDDGKPSQTLFQVVKREVHSDGTHTTVVRLLPITGRSHQLRVHLMAIGHAIV 180

Query: 177 GDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
           GD FYA+ EA   + RL LHA  L+  HPA     +   P DF
Sbjct: 181 GDEFYATEEAYQFSERLELHAAELSFYHPATDQLSSIFVPCDF 223


>UniRef50_A3RGY8 Pseudouridine synthase n=1 Tax=uncultured bacterium
           RepID=A3RGY8_9BACT
          Length = 353

 Score =  290 bits (743), Expect = 3e-77,   Method: Composition-based stats.
 Identities = 78/228 (34%), Positives = 116/228 (50%), Gaps = 19/228 (8%)

Query: 8   PPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR-----DYPQAESVHR 62
            P+   L ++++DD I+V+NKP  L+  P         +   +       D P+A  VHR
Sbjct: 104 KPEPMPLEVIFEDDAILVLNKPPKLVVHPAAGHWSGTLLNGLLAYAPTLIDVPRAGIVHR 163

Query: 63  LDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNR 122
           LD  TSG++VVA T AA+ +L RQ + R   ++Y A V G PS   G++D  +  D  N 
Sbjct: 164 LDADTSGLMVVAKTLAAQTDLVRQLQSRTVTREYWALVLGVPSQ-RGVIDAAIGRDPRNP 222

Query: 123 PKQKVC-YETGKPAQTEYEVV---EYAADNTARVVLKPITGRSHQLRVHMLALGHPILGD 178
            + KV   E  KPA+T Y  +   + A  + + +  +  TGR+HQ+RVH+  +GHP++GD
Sbjct: 223 LRFKVSTTEAAKPARTHYATLDSTKNAGADISWLACRLETGRTHQIRVHLEHVGHPLIGD 282

Query: 179 RFY-------ASPEARAM-APRLLLHAEMLTITHPAYGNSMT-FKAPA 217
             Y         P AR     R  LHA  L + HP     +  F +PA
Sbjct: 283 PVYRRRLPPRGEPAARWKEFDRQALHACRLALDHPVSRQRLNWFHSPA 330


>UniRef50_Q2S3B7 Pseudouridine synthase n=1 Tax=Salinibacter ruber DSM 13855
           RepID=Q2S3B7_SALRD
          Length = 349

 Score =  289 bits (742), Expect = 4e-77,   Method: Composition-based stats.
 Identities = 76/262 (29%), Positives = 112/262 (42%), Gaps = 52/262 (19%)

Query: 8   PPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------------- 52
            P+   L ++++ D ++VVNKP+G++  P         V   +                 
Sbjct: 68  EPEAIPLDVVHEGDDLLVVNKPAGMVVHPAPGHRSGTLVHALLHHVDGGEVAADDERDEV 127

Query: 53  -----------------DYP--QAESVHRLDMATSGVIVVALTKAAERELKRQFREREPK 93
                            D+P  +   VHRLD  TSG++VVA    A + L  QF+     
Sbjct: 128 SEDEVGLSLVNALPQSPDHPVVRPGIVHRLDKGTSGLLVVAKRGRAHQPLAEQFKAHTVD 187

Query: 94  KQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYET-GKPAQTEYEVVEYAADNTARV 152
           ++Y A VWG  +P++G ++  +  D  +R +  V  E  GK A+T YE VE  A +T+ V
Sbjct: 188 RRYRAIVWGRFAPSDGTIEGAIGRDPHHRQRMAVVPEDEGKWARTHYETVETHA-HTSVV 246

Query: 153 VLKPITGRSHQLRVHMLALGHPILGDRFYASPEARAM----------------APRLLLH 196
             +  TGR+HQ+RVH  A GHP+LGD  Y     R                   P   LH
Sbjct: 247 EFELETGRTHQIRVHARAQGHPLLGDPKYGGQRVRYGTQSGTRRTFYDQLFETLPHPALH 306

Query: 197 AEMLTITHPAYGNSMTFKAPAD 218
           A  L   HP     + F+A   
Sbjct: 307 AYRLGFDHPTTEERLRFEADPP 328


>UniRef50_B1ZYX0 Pseudouridine synthase n=4 Tax=Verrucomicrobia RepID=B1ZYX0_OPITP
          Length = 311

 Score =  289 bits (741), Expect = 4e-77,   Method: Composition-based stats.
 Identities = 84/221 (38%), Positives = 117/221 (52%), Gaps = 13/221 (5%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR---------DYPQAESV 60
            +  L +L++D H++ VNK +G++  PG        V   +              +   V
Sbjct: 76  VDIPLTVLFEDKHMLAVNKAAGMVVHPGVATSEDTLVHALLAHCAGSLSGIGGVERPGIV 135

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLD  T+GVIVVA T AA R L  QF  R  KK+YVA V G P    G +D  +     
Sbjct: 136 HRLDKETTGVIVVAKTDAAHRALADQFATRTLKKEYVALVAGVPRLLSGSIDRAIARHPV 195

Query: 121 NRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRF 180
           +R +  V  E G+PA+T++E+VE   D  A V  +  TGR+HQ+RVH+ +LGHPILGD  
Sbjct: 196 HRHRMTV-GEGGRPARTDWELVEAFGDIGALVRCRIFTGRTHQIRVHLKSLGHPILGDAL 254

Query: 181 YASPEARAMA---PRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           Y       +A    R++LHAE L +THP  G  +  +AP  
Sbjct: 255 YGWKPEPRLATQPARVMLHAEHLVLTHPISGKELDLRAPLP 295


>UniRef50_A1AW00 Pseudouridine synthase n=2 Tax=sulfur-oxidizing symbionts
           RepID=A1AW00_RUTMC
          Length = 314

 Score =  288 bits (740), Expect = 6e-77,   Method: Composition-based stats.
 Identities = 75/226 (33%), Positives = 115/226 (50%), Gaps = 20/226 (8%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRD-----YPQAESVHRLD 64
           Q+  + ++Y+D+ I++VNKP  L++ PG            +  D       +A  VHRLD
Sbjct: 76  QDIVIDVVYEDEAIIIVNKPVNLVTHPGVSNWTGTLANALLHYDSSLANLDRAGIVHRLD 135

Query: 65  MATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPK 124
             TSG++VVA ++ A++ L RQ +     ++Y A V+GH     G VD P+  D  +R +
Sbjct: 136 KNTSGLMVVARSEYAQKYLTRQLQTHSISREYSAIVYGHMISG-GTVDKPIGRDPKDRIR 194

Query: 125 QKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYAS- 183
           Q V  E+GK A T Y V+E  A +   V +   TGR+HQ+RVH+  +GHP++ D  Y   
Sbjct: 195 QTV-TESGKDALTHYRVIERFAHH-THVKVMLETGRTHQIRVHLSFIGHPLIADPMYGGK 252

Query: 184 -----------PEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
                        +     R  LHA+ LT+ HP     M++K P  
Sbjct: 253 IRFPKKADKQLKNSLKNFNRQTLHAKKLTLIHPTSTELMSWKVPLP 298


>UniRef50_A3MZ33 Pseudouridine synthase n=9 Tax=Proteobacteria RepID=A3MZ33_ACTP2
          Length = 237

 Score =  288 bits (740), Expect = 6e-77,   Method: Composition-based stats.
 Identities = 136/222 (61%), Positives = 170/222 (76%), Gaps = 3/222 (1%)

Query: 1   MGMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESV 60
           M +  Y+PP EP+L  +Y+D+HI+V+NKPSGLLSVPG   E+ DS MTR+Q+ Y   E  
Sbjct: 16  MALIEYHPPLEPFLTEVYRDNHILVINKPSGLLSVPGNRPEYYDSAMTRVQQKYGFTEPA 75

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSP---AEGLVDLPLIC 117
           HRLDMATSG+++ AL+KAAE+ELKRQFR+REPKK Y+A +WG         G ++ PLIC
Sbjct: 76  HRLDMATSGILLFALSKAAEKELKRQFRDREPKKHYIALLWGKLGEKVGDTGEMNFPLIC 135

Query: 118 DWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILG 177
           DW NRP+QK+CYE GK A T YEV+ +  +NT RV L PITGRSHQLRVH LALGHPILG
Sbjct: 136 DWENRPRQKICYERGKKAITHYEVLAHLPNNTTRVKLTPITGRSHQLRVHSLALGHPILG 195

Query: 178 DRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
           D+FYASP A++++PRL LHAE L+ITHP  G +MTF A  +F
Sbjct: 196 DKFYASPLAKSLSPRLCLHAESLSITHPITGEAMTFTAQTEF 237


>UniRef50_D2R7T3 Pseudouridine synthase, RluA family n=1 Tax=Pirellula staleyi DSM
           6068 RepID=D2R7T3_9PLAN
          Length = 355

 Score =  288 bits (740), Expect = 6e-77,   Method: Composition-based stats.
 Identities = 72/232 (31%), Positives = 105/232 (45%), Gaps = 23/232 (9%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYPQAESV 60
           P++  L IL++D+H++ VNKP G++  P R                         +   V
Sbjct: 110 PEKIPLDILFEDEHLIAVNKPPGMVVHPARGHWSGTLTSALAFHFQQLSTVGGQHRPGIV 169

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLD  TSGVI+VA T      L  QF +R   K+Y A   G P     +V  P+     
Sbjct: 170 HRLDRDTSGVIIVAKTDPVHFSLAAQFADRTTAKEYFAITAGVPDRDRDVVSQPIGIHPF 229

Query: 121 NRPKQKVC--YETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGD 178
           +R K  +   + T + A+T + V+E  A + A V   P TGR+HQ+RVH+  +  P+L D
Sbjct: 230 HREKMAIRPGHSTSRDAETMFHVLERFAQHAA-VECLPKTGRTHQIRVHLAHVRTPVLCD 288

Query: 179 RFYASPEA------------RAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           + Y                   +  R  LHA  L+I HP  G  +T +AP  
Sbjct: 289 KLYGGRAEITQGELVRDGSTEVVLNRQALHARKLSINHPKTGERLTIEAPLP 340


>UniRef50_C1F7V3 Pseudouridine synthase n=1 Tax=Acidobacterium capsulatum ATCC 51196
           RepID=C1F7V3_ACIC5
          Length = 355

 Score =  288 bits (740), Expect = 7e-77,   Method: Composition-based stats.
 Identities = 69/244 (28%), Positives = 105/244 (43%), Gaps = 35/244 (14%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLE-----EHKDSVMTRIQRDYP--------Q 56
           ++  L I+Y+D  ++VVNKP+G++   G             V   + R           +
Sbjct: 100 EDIPLDIIYEDKDLIVVNKPAGMMVHAGSGATDSARNRGTLVNALLGRQEKLSKTGGDLR 159

Query: 57  AESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLI 116
              VHRLD  TSG+I+VA   AA + L   F +RE  K Y+A V GH +   G ++  + 
Sbjct: 160 PGIVHRLDKETSGLIIVARNDAAHQRLAEMFSQREIHKTYLALVHGHIAEDRGTINAAIA 219

Query: 117 CDW-PNRPKQKVCYETGKPAQTEYEV---VEYAADNTARVVLKPITGRSHQLRVHMLALG 172
            D            E  + A + Y V   +E        V ++  TGR+HQ+RVH+ ++G
Sbjct: 220 RDVIRRTRMTTRRTEGARTAISHYRVQRRIETRWGKFTLVSVRIETGRTHQIRVHLSSIG 279

Query: 173 HPILGDRFYASPEARAM------------------APRLLLHAEMLTITHPAYGNSMTFK 214
           HP++GD  Y +P    +                   PR  LHA  L   HP     +  +
Sbjct: 280 HPVVGDTHYGAPTTIVLPVANRARRKQLPAPEGLSLPRNFLHAAELKFPHPRSEKPLHLE 339

Query: 215 APAD 218
           AP  
Sbjct: 340 APLP 343


>UniRef50_C1ZGS9 Pseudouridine synthase n=1 Tax=Planctomyces limnophilus DSM 3776
           RepID=C1ZGS9_PLALI
          Length = 345

 Score =  288 bits (740), Expect = 7e-77,   Method: Composition-based stats.
 Identities = 80/243 (32%), Positives = 109/243 (44%), Gaps = 28/243 (11%)

Query: 2   GMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDY------- 54
             +    P++  L ILY D+++ V+NK + ++  PGR       +   +Q  +       
Sbjct: 79  EPDQRVQPEDIPLDILYDDEYLCVINKTANMIVHPGRGNYRGT-LAGALQFHFDSLSDVA 137

Query: 55  --PQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVD 112
              +A  VHRLD  TSGV+VVA      + L RQF ER  +K+Y A VWG        V+
Sbjct: 138 GQYRAGIVHRLDRDTSGVLVVAKDNTVHQHLSRQFEERSVEKEYHAIVWGEMQFDADYVE 197

Query: 113 LPLICDWPNRPKQKVCYE--TGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLA 170
             +   + NR +  VC      + A T YEV +        V L+P TGR+HQLRVHM  
Sbjct: 198 TYVRVSFRNRERMMVCPPGDNARQAATFYEVQQRFR-GFTYVKLQPQTGRTHQLRVHMHH 256

Query: 171 LGHPILGDRFYASPE---------------ARAMAPRLLLHAEMLTITHPAYGNSMTFKA 215
           LGHPI+ DR Y                      +  R  LHA  L   HP     M F+A
Sbjct: 257 LGHPIIADRLYEGKTCVKLSDILPETPEEADETLIDRQALHARRLAFNHPVTKKRMVFEA 316

Query: 216 PAD 218
           P  
Sbjct: 317 PLP 319


>UniRef50_Q7UHX8 Pseudouridine synthase n=1 Tax=Rhodopirellula baltica
           RepID=Q7UHX8_RHOBA
          Length = 334

 Score =  288 bits (739), Expect = 8e-77,   Method: Composition-based stats.
 Identities = 79/251 (31%), Positives = 107/251 (42%), Gaps = 37/251 (14%)

Query: 4   ENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYP 55
            +   P+   L ILY+DD ++V+NKP+G++  P R             R           
Sbjct: 69  SDDTVPENIPLDILYEDDGLVVINKPAGMVVHPARGNWTGTLTSALAFRFQSLSDVGGPT 128

Query: 56  QAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPL 115
           +   VHRLD  TSGVIVVA   A    L  Q+ +R  +K+Y A  +G        +   +
Sbjct: 129 RPGIVHRLDRDTSGVIVVAKNNAVHLNLAAQWHDRLVQKEYTAITFGRLDRDRDWIHASI 188

Query: 116 ICDWPNRPKQKVC--YETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGH 173
                 R KQ +   + T K A T YEVVE       RV ++P TGR+HQ+RVH+  +G 
Sbjct: 189 GRHPYQRDKQAIREGHATSKTASTFYEVVERHG-RVTRVDVRPKTGRTHQIRVHLAHIGC 247

Query: 174 PILGDRFYASPE--------------------------ARAMAPRLLLHAEMLTITHPAY 207
           PIL DR Y                                 +  R  LHA+ LT T+P  
Sbjct: 248 PILCDRLYGGHSELSRSQIRRLAGTEVATPGVKPTPEGEEILLSRQALHAKALTFTNPQT 307

Query: 208 GNSMTFKAPAD 218
           G  MT  AP  
Sbjct: 308 GKEMTLTAPLP 318


>UniRef50_A6LDZ7 Pseudouridine synthase n=26 Tax=Bacteroidales RepID=A6LDZ7_PARD8
          Length = 549

 Score =  288 bits (739), Expect = 8e-77,   Method: Composition-based stats.
 Identities = 92/218 (42%), Positives = 121/218 (55%), Gaps = 21/218 (9%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ---AESVHRLDMATSGV 70
           L ILY+DD+++V+NKP G+LSVPG+ +   DSV  R+   YP+      VHRLDMATSG+
Sbjct: 340 LDILYEDDYLLVINKPEGMLSVPGKGDA--DSVYQRLSILYPEATGPIIVHRLDMATSGL 397

Query: 71  IVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYE 130
           ++ A TK A + L+ QF+ R  +K+Y+A + G     EG + LPL  D  +RP+Q V  E
Sbjct: 398 LLAAKTKEAHQNLQAQFKNRTIQKRYIALLEGEVPQDEGEIRLPLCPDPLDRPRQIVSEE 457

Query: 131 TGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLA---LGHPILGDRFYASPEAR 187
            GKPA T Y V+E  +     +   P TGR+HQLRVH      L  PILGD  Y      
Sbjct: 458 FGKPALTHYRVLERTSGK-TLIAFYPQTGRTHQLRVHAAHPLGLHCPILGDELYGRK--- 513

Query: 188 AMAPRLLLHAEMLTITHPAYGNSMTFK-------APAD 218
             A RL LHAE L  THP     +  +        P  
Sbjct: 514 --AERLYLHAEYLAFTHPITSERIEIQKSPAFPRCPMP 549


>UniRef50_A0Q1S9 Pseudouridine synthase n=32 Tax=Clostridium RepID=A0Q1S9_CLONN
          Length = 301

 Score =  288 bits (739), Expect = 8e-77,   Method: Composition-based stats.
 Identities = 64/223 (28%), Positives = 109/223 (48%), Gaps = 10/223 (4%)

Query: 2   GMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ----- 56
                  P++  L ++Y+D  I+V+NKP G++  P +  ++   +   +   + +     
Sbjct: 71  EENQDIVPEKMHLDVIYEDKDIVVINKPKGIVVHPTKRHQNGT-LSNGVLYYFKEKNENS 129

Query: 57  -AESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPL 115
               V+RLDM TSG++++A    +   L R  ++ +  K Y+A V G+     G+++ P+
Sbjct: 130 IVRLVNRLDMDTSGLVLIAKNAYSHMALSRDMQKDDFVKSYLAIVHGNLKEKSGVINKPI 189

Query: 116 ICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPI 175
                   ++ V  E G+ + T ++VVE   D    V L   TGR+HQ+RVH+ ++GHPI
Sbjct: 190 YRVGEGTLRR-VIDERGQRSVTRFKVVESYED-ADLVELTLETGRTHQIRVHLSSIGHPI 247

Query: 176 LGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
            GD  Y   E      R  LHA  L I HP  G  +  ++   
Sbjct: 248 YGDSLYG-KEEHEYIDRQALHAYKLQIPHPKDGRILKLESDLP 289


>UniRef50_UPI0001C42CC7 hypothetical protein BpOF4_01845 n=1 Tax=Bacillus pseudofirmus OF4
           RepID=UPI0001C42CC7
          Length = 322

 Score =  288 bits (739), Expect = 9e-77,   Method: Composition-based stats.
 Identities = 68/221 (30%), Positives = 106/221 (47%), Gaps = 11/221 (4%)

Query: 4   ENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES---- 59
                P+   L I Y+DDH++V+NKP G+ ++P R    +  +   +   Y         
Sbjct: 95  NESLRPECIPLDIHYEDDHLLVINKPQGMPTIPSREHPSRT-LANAVMGYYESHHIPFTF 153

Query: 60  --VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLIC 117
             V+RLD  TSG++VVA    A  +L +  R  + K+ Y+A   G   P EG +  P+  
Sbjct: 154 HAVNRLDRDTSGLLVVAKHGLAHDQLSKGQRAGKLKRYYLALAEGFVQPREGTIHAPIKR 213

Query: 118 DWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILG 177
              +  ++ V    G+ A T Y+V+       + V +   TGR+HQ+RVH   LGHP+LG
Sbjct: 214 RPSSIIERMV-AADGQEAITHYKVI-NDNQAYSEVEINLETGRTHQIRVHFAHLGHPLLG 271

Query: 178 DRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           D  Y    +  +  R  LH + + + HP  G  + F AP  
Sbjct: 272 DDLYGG--SIELLARQALHCQRVELIHPFTGKHLHFSAPLP 310


>UniRef50_C9M7B4 Pseudouridine synthase n=1 Tax=Jonquetella anthropi E3_33 E1
           RepID=C9M7B4_9BACT
          Length = 301

 Score =  288 bits (738), Expect = 1e-76,   Method: Composition-based stats.
 Identities = 71/223 (31%), Positives = 109/223 (48%), Gaps = 10/223 (4%)

Query: 4   ENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP------QA 57
           E    PQ+     +Y DD + VV K +G+   PG   +    V   ++   P      + 
Sbjct: 68  EESVVPQDVPFRTVYADDWLAVVEKLAGIAVHPGAGRKDGTLVNGLVKTFGPLPGAGLRP 127

Query: 58  ESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLIC 117
             VHRLD+ TSG++VVA T  A   L+R+F +R  +K Y+A V G    ++G +D P+  
Sbjct: 128 GIVHRLDIGTSGLMVVARTPQAYLFLQREFSQRRVEKTYLALVHGWIPASQGTLDGPIGR 187

Query: 118 DWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILG 177
              +R K  V    G+ A T Y  +       +    +  TGR+HQ+RVHM ++G  + G
Sbjct: 188 SRYDRLKMAV-RADGRRAVTRYRTLWTRGS-LSLTACRIETGRTHQIRVHMASIGCYLDG 245

Query: 178 DRFYASPEARAMA--PRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           DR Y   +        R+ LHA  L+  HP+ G +M F++P  
Sbjct: 246 DRLYGPKDVSRHFLEGRVFLHAWRLSFHHPSDGRTMNFRSPLP 288


>UniRef50_C0QV86 Pseudouridine synthase n=2 Tax=Brachyspira RepID=C0QV86_BRAHW
          Length = 329

 Score =  288 bits (738), Expect = 1e-76,   Method: Composition-based stats.
 Identities = 60/214 (28%), Positives = 101/214 (47%), Gaps = 12/214 (5%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYPQAESV 60
           P+   L ILY+D +++V+NKP+G+       E     V   + +        +  +A  +
Sbjct: 104 PENIDLDILYEDKYLLVINKPAGMSVHCSPSEMSGTLVNALLYKIKDFDFVGNKERAGII 163

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLD  TSG++++         ++ QF+ R  KK Y A V G        ++LP+     
Sbjct: 164 HRLDKDTSGLMIIGKNANIVSSIQEQFKNRTIKKIYHAIVVGVLKDNYIEINLPIGRHHV 223

Query: 121 NRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRF 180
            R K  V  E GK A T  +V++    +   + +   TGR+HQ+RVH    G P+ GD+ 
Sbjct: 224 YRKKMTV-REDGKEALTHIKVLKRFNSH-TLIEINLKTGRTHQIRVHSSYKGFPVAGDKI 281

Query: 181 YASPEARAMAPRLLLHAEMLTITHPAYGNSMTFK 214
           Y   ++ +    L+L A+ +   HP     + F+
Sbjct: 282 Y--SKSFSKYSGLMLVAKKIEFMHPITKELLDFE 313


>UniRef50_A5IZB6 Pseudouridine synthase n=4 Tax=Mycoplasma RepID=A5IZB6_MYCAP
          Length = 305

 Score =  287 bits (737), Expect = 1e-76,   Method: Composition-based stats.
 Identities = 55/230 (23%), Positives = 99/230 (43%), Gaps = 16/230 (6%)

Query: 1   MGMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR-------- 52
           +  E+     +  L I Y+D++++++NKPSGL+  P     +   V   +          
Sbjct: 63  LEKESNIEAVDMPLDIRYEDEYLLILNKPSGLVVHPAPGHLNDTLVNALMYHFKNNLSDA 122

Query: 53  -DYPQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLV 111
               +   VHR+D  TSG++++A       EL +  +  + K+ Y+A   G        +
Sbjct: 123 NGLLRLGIVHRIDKDTSGLLIIAKDNETHNELAKMLKNHQIKRTYLAICEGILPNKTTKI 182

Query: 112 DLPLICDWPNRPKQKVCYETGKPAQTEYEVVEYA---ADNTARVVLKPITGRSHQLRVHM 168
           +LP+  D  NR    + ++ GK + T   +++         + V  +  TGR+HQ+RVH+
Sbjct: 183 NLPIQRDTKNRKLMSI-HKDGKSSVTYVHMLKSFYIDNKPYSLVKCELETGRTHQIRVHL 241

Query: 169 LALGHPILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
             + HP+ GD  Y             LHA  L+  HP     +   +   
Sbjct: 242 AYIKHPVYGDSIYGKSVDEFN---QRLHAYKLSFMHPVINKLIEVYSDIP 288


>UniRef50_A0LPH5 Pseudouridine synthase n=1 Tax=Syntrophobacter fumaroxidans MPOB
           RepID=A0LPH5_SYNFM
          Length = 344

 Score =  287 bits (737), Expect = 1e-76,   Method: Composition-based stats.
 Identities = 70/236 (29%), Positives = 115/236 (48%), Gaps = 22/236 (9%)

Query: 4   ENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYP 55
           E+   P+   L IL++DD ++V+NK  G++  PG   E    V   +             
Sbjct: 77  EDSLQPRPMPLEILFEDDDVLVLNKAPGVIVHPGAGHEEGTLVHGLLAHCSRLASRGAPR 136

Query: 56  QAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPL 115
           +   VHRLD  TSG ++VA ++ A  EL RQF+  E  K+Y+A V+G  + A G +   +
Sbjct: 137 RPGIVHRLDRGTSGALMVAKSERAYLELIRQFKHHEVGKEYLALVYGTMAGASGEIRTGM 196

Query: 116 ICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPI 175
                +R +  V  + G+ A ++++V     +  + + +   TGR+HQ+RVH+  + HP+
Sbjct: 197 GRHPVDRKRMAVLEKGGREAVSQWKVAVAWGE-VSLLRVVIKTGRTHQIRVHLSHMQHPV 255

Query: 176 LGDRFYASPEARAMA-------------PRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           +GD  Y   + +A A              R +LHA  L   HP  G  ++F AP  
Sbjct: 256 VGDETYGGGKRKARAVKSDVLRELLMEVDRQMLHAVGLAFRHPVSGADLSFTAPLP 311


>UniRef50_Q0F3G2 Possible pseudouridine synthase n=1 Tax=Mariprofundus ferrooxydans
           PV-1 RepID=Q0F3G2_9PROT
          Length = 325

 Score =  287 bits (737), Expect = 2e-76,   Method: Composition-based stats.
 Identities = 73/233 (31%), Positives = 112/233 (48%), Gaps = 22/233 (9%)

Query: 6   YNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYPQA 57
              P++  L IL++D+H++V+NKP+G++  P    +H   V   +             + 
Sbjct: 80  ILEPEDLPLDILFEDEHLIVLNKPAGIVVHPSHGHDHGTLVHALLHHCKTLPGINGVERP 139

Query: 58  ESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLIC 117
             VHRLD  TSG +V+A ++   + L   F E    +QY+A   G PS     ++LP+  
Sbjct: 140 GIVHRLDKDTSGSLVIAKSEVVHQRLSEMFAEHNLNRQYIAWCRGVPSWRVKCIELPIGR 199

Query: 118 DWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILG 177
               R K  V  ++G+ + T+  V E+     +++ L   TGR+HQ+RVHM     P+LG
Sbjct: 200 HPHQRQKMAV-TDSGRESITDAAV-EHIFGPFSQMRLTLHTGRTHQIRVHMAHENLPVLG 257

Query: 178 DRFYAS------------PEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           D  YA               A A   R  LHAE+L   HP  G  M+F+AP  
Sbjct: 258 DPVYARSYHPGREIPEPARHAIATLSRQALHAELLEFDHPISGEPMSFRAPLP 310


>UniRef50_B7GLK3 Pseudouridine synthase n=11 Tax=Bacillaceae RepID=B7GLK3_ANOFW
          Length = 292

 Score =  287 bits (737), Expect = 2e-76,   Method: Composition-based stats.
 Identities = 66/214 (30%), Positives = 106/214 (49%), Gaps = 9/214 (4%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ-----AESVHRLD 64
           +   L I+Y+DD+++V+NKP  + ++P R   H       +     Q        V RLD
Sbjct: 76  EPIPLAIVYEDDYVIVINKPPHMSTIPSREHPHGTLANALLHHYEQQQLQTTVHVVTRLD 135

Query: 65  MATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPK 124
             TSG+++VA  +     L  Q ++   K++Y A   G+     G +D P+     +  +
Sbjct: 136 RDTSGLVLVAKHRHVHHLLSEQQKQGRVKRRYEAVCHGYVIQLVGTIDAPIGRKGDSIIE 195

Query: 125 QKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASP 184
           ++V    G+ A T YEV++   +    V ++  TGR+HQ+RVH   +GHP++GD  Y   
Sbjct: 196 REV-RLDGQRAVTHYEVLQQ-KNEMTHVSIQLETGRTHQIRVHFSHIGHPLVGDDLYGG- 252

Query: 185 EARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
             R    R  LH+  LT  HP +  +MTF AP  
Sbjct: 253 -LREHIDRQALHSCELTFFHPFFEKTMTFHAPLP 285


>UniRef50_C6JBH1 Pseudouridine synthase n=1 Tax=Ruminococcus sp. 5_1_39BFAA
           RepID=C6JBH1_9FIRM
          Length = 299

 Score =  287 bits (736), Expect = 2e-76,   Method: Composition-based stats.
 Identities = 64/214 (29%), Positives = 106/214 (49%), Gaps = 11/214 (5%)

Query: 11  EPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAE------SVHRLD 64
           +  L I+Y+D+ I+V+NKP+ +   P     +++++   I   + +         ++RLD
Sbjct: 78  KMDLNIIYEDEDILVINKPADMPVHPSAGN-YENTLANGIAWYFAEKGEDFVYRCINRLD 136

Query: 65  MATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPK 124
             T+G +++A    +   L  Q ++R+  + Y+A V G   P  G ++ P+     +   
Sbjct: 137 RDTTGALILAKNPLSAAILSVQMKKRQILRTYLALVDG-LLPDSGTINAPIARMEGSVIT 195

Query: 125 QKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASP 184
           ++V + TG+ A T YE +  A    +   L   TGR+HQ+RVHM  +GHP+ GD  Y   
Sbjct: 196 REVNFGTGESAITHYERLA-AGKEYSLAELHLETGRTHQIRVHMKYIGHPLPGDYLYNPD 254

Query: 185 EARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
             R    R  LH+  L  THP  G  M F AP  
Sbjct: 255 YRR--INRQPLHSYQLEFTHPTTGKVMLFTAPLP 286


>UniRef50_Q2GGY1 Pseudouridine synthase n=13 Tax=Rickettsiales RepID=Q2GGY1_EHRCR
          Length = 337

 Score =  287 bits (736), Expect = 2e-76,   Method: Composition-based stats.
 Identities = 60/234 (25%), Positives = 105/234 (44%), Gaps = 22/234 (9%)

Query: 4   ENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP-------- 55
           +   P     + ++Y+D  I+++NK  G+   PG    +   V   +             
Sbjct: 86  DTITPNHYIPISVVYEDHDIIIINKAPGITVHPGAGTNNNTLVNALVAHYGNSLSHVGKA 145

Query: 56  -QAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLP 114
            +   +HRLD  TSG++V+A  + +   L     +++ KK+Y+A VWG P+P    +   
Sbjct: 146 TRPGIIHRLDKDTSGLMVIAKNEKSYYFLSDLLLKKQIKKEYLAVVWGLPNPKSNTIKNY 205

Query: 115 LICDWPNRPKQKVCY--ETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALG 172
           +     N+    V +    GK A TEY+  +  ++  + +  +  TGR+HQ+RVHM  +G
Sbjct: 206 ICVKPNNKQMMTVTHLPHKGKLAITEYQTQKSFSNIASLIKCRIHTGRTHQIRVHMSYIG 265

Query: 173 HPILGDRFYASPEAR-----------AMAPRLLLHAEMLTITHPAYGNSMTFKA 215
           + I+GD+ Y    ++               R  LHA  L  THP     + F +
Sbjct: 266 NSIIGDQKYGKNNSKSVKYAKQSTIINTLKRQALHAYKLGFTHPTSNTYIEFHS 319


>UniRef50_C6J6E3 Pseudouridine synthase n=2 Tax=Bacillales RepID=C6J6E3_9BACL
          Length = 321

 Score =  286 bits (734), Expect = 3e-76,   Method: Composition-based stats.
 Identities = 73/237 (30%), Positives = 111/237 (46%), Gaps = 23/237 (9%)

Query: 2   GMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP------ 55
                  P+     I+Y+D+ +++VNK +GL+  P         +   +   +       
Sbjct: 73  ETSTDILPEPIPFDIVYEDEALLIVNKAAGLIVHPTHGHYTGT-LANGVVYYWQEKGEKF 131

Query: 56  QAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPL 115
           +   VHRLD  TSG+I +A      + +  Q    E  K+Y A V G P+  EG +D P+
Sbjct: 132 RFRPVHRLDQETSGLIAIAKNAYVHQHISEQLIAGEVTKKYTALVHGCPAVPEGTIDGPI 191

Query: 116 ICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPI 175
             D    P +++   +G P+ T Y+V E   D   RV L+  TGR+HQ+RVHM ++GHP+
Sbjct: 192 DRDPAE-PHRRIVTPSGYPSLTYYKVAEAYGDGA-RVELRLGTGRTHQIRVHMTSIGHPL 249

Query: 176 LGDRFYASP--------------EARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           +GD+FY  P                 A   R  LHA  L   HP  G ++TFK+   
Sbjct: 250 IGDKFYGMPGLAELPAPARERIARLDAAIGRQALHASELGFRHPLTGEALTFKSELP 306


>UniRef50_A6NQQ9 Pseudouridine synthase n=1 Tax=Bacteroides capillosus ATCC 29799
           RepID=A6NQQ9_9BACE
          Length = 300

 Score =  286 bits (734), Expect = 3e-76,   Method: Composition-based stats.
 Identities = 76/223 (34%), Positives = 111/223 (49%), Gaps = 10/223 (4%)

Query: 2   GMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES-- 59
            +     P    L I+YQD  ++V+NK  G+   PG      D++   +   Y +     
Sbjct: 72  EVSGAIVPAPGPLDIVYQDQDVLVLNKAPGVAVHPGPGHYS-DTIGNFLMDYYRKQGILA 130

Query: 60  ----VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPL 115
               VHRLD  TSG+++VAL   A+  LK Q      ++ Y+A   G P+P  G++D P+
Sbjct: 131 DFHPVHRLDRGTSGLLLVALHGHAQEVLKEQLHSPSFRRVYLAVCEGAPNPPSGVIDAPI 190

Query: 116 ICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPI 175
                +   + V    G+ A T Y  +    D    V L+  TGR+HQ+RVHM  LGHP+
Sbjct: 191 GRLEGSVLARTV-RPDGQRAVTHYRTLRTVNDRA-LVRLELETGRTHQIRVHMAHLGHPL 248

Query: 176 LGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
            GD  Y + E +++ PR  LHA  L+ THP  G +M F AP  
Sbjct: 249 TGDFLYGT-EDQSLIPRPALHAAELSFTHPITGKTMAFTAPLP 290


>UniRef50_B6BTN1 Pseudouridine synthase n=2 Tax=Betaproteobacteria
           RepID=B6BTN1_9PROT
          Length = 346

 Score =  286 bits (734), Expect = 3e-76,   Method: Composition-based stats.
 Identities = 69/239 (28%), Positives = 106/239 (44%), Gaps = 22/239 (9%)

Query: 1   MGMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR-----DYP 55
           +  E     +   L I+Y+DD I+V+NKP  L+  PG    +   +   +         P
Sbjct: 71  IEDEIDVIAENISLDIVYEDDDILVLNKPYNLVVHPGSGNANGTLLNGLLYYNKDLEKLP 130

Query: 56  QAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPL 115
           +   VHRLD  T+G++VVA  + ++  L  Q + +   ++Y A VWG     + ++  P+
Sbjct: 131 RGGIVHRLDKDTTGLMVVAKNEESQNNLISQLQSKSVYREYRAIVWGQIWQNK-VIQKPI 189

Query: 116 ICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPI 175
                 R K  V    GK A+T+ E++E    +   V     TGR+HQ+RVHML    PI
Sbjct: 190 GRHPRQRTKMAVTKVNGKDAETKLEILERFNYH-TYVRCLLKTGRTHQIRVHMLDNNSPI 248

Query: 176 LGDRFYASP-------------EARAMAPRLLLHAEMLTITHPAYGNSM--TFKAPADF 219
           +GD+ Y                ++     R  LHA  L + HP     M  T   P D 
Sbjct: 249 VGDKDYGLKKIIPTKNMEMDLLKSIKNFDRQALHAIALGLIHPKTNKEMKWTIDLPEDM 307


>UniRef50_Q63E77 Pseudouridine synthase n=73 Tax=Bacillaceae RepID=Q63E77_BACCZ
          Length = 307

 Score =  286 bits (734), Expect = 3e-76,   Method: Composition-based stats.
 Identities = 65/225 (28%), Positives = 101/225 (44%), Gaps = 11/225 (4%)

Query: 1   MGMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP----- 55
           M  E    P+   L ++Y+DDH+++VNKP  + + P         +   +   +      
Sbjct: 72  MEEEYDVEPEYGELHVVYEDDHVLIVNKPEKMDTHPSEKGGMGT-LANLVAFHFQMQGLE 130

Query: 56  -QAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLP 114
            +   +HRLD  T+G +V A  + A   + R   ER+ K+ Y A V G     +G +D  
Sbjct: 131 TKVRHIHRLDKDTTGGVVFAKHRIAGAIMDRLLMERKIKRTYAALVEGKVKKKQGTIDAA 190

Query: 115 LICDWPNRPKQKVCYETGKPAQTEYEVVEYA-ADNTARVVLKPITGRSHQLRVHMLALGH 173
           +  D  +  +++V    G  A T Y+V EY    N   V L+  TGR+HQ+RVHM   G+
Sbjct: 191 IGRDRHHATRRRV-SPKGDQAITYYKVEEYFKKQNVTLVTLQLETGRTHQIRVHMSYNGN 249

Query: 174 PILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           P++GD  Y          R  LHA  +   HP     +    P  
Sbjct: 250 PLVGDVLYGGGT--KYMSRQALHAMKINFLHPITKEEIEVDVPFP 292


>UniRef50_B7GEZ0 Pseudouridine synthase n=7 Tax=Bacillaceae RepID=B7GEZ0_ANOFW
          Length = 315

 Score =  286 bits (734), Expect = 3e-76,   Method: Composition-based stats.
 Identities = 67/223 (30%), Positives = 111/223 (49%), Gaps = 13/223 (5%)

Query: 1   MGMENYNP-PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP---- 55
           +  E   P P    L I+++DDH++VVNK + +   P +  +  +++   +   +     
Sbjct: 82  IKEEQIEPTPTYVPLHIVFEDDHVLVVNKRAHMDVHPTQPGQT-NTLANAVAFHFQCEGI 140

Query: 56  --QAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDL 113
             +   +HRLD  TSGVI+ A    A   L +   +R  ++ Y+A V G+    +G ++ 
Sbjct: 141 YSKVRHIHRLDRDTSGVILFAKHALAGAILDQYLAKRTIRRTYIALVHGYVKQKKGTIEA 200

Query: 114 PLICDWPNRPKQKVCYETGKPAQTEYEVVEYAAD-NTARVVLKPITGRSHQLRVHMLALG 172
           P+  D  +  +++V  +TG  A T YE ++Y    + + V L   TGR+HQ+RVHM  +G
Sbjct: 201 PIGRDRHHPTRRRV-SKTGDTAITHYERLQYDKQKHVSLVRLTLDTGRTHQIRVHMSYIG 259

Query: 173 HPILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKA 215
           HP++GD  Y          R  LHA  L+  HP     +T  A
Sbjct: 260 HPLVGDTLYGGK---PWIDRQALHAFSLSFLHPFTEELITCSA 299


>UniRef50_Q5PAD0 Pseudouridine synthase n=5 Tax=Anaplasma RepID=Q5PAD0_ANAMM
          Length = 327

 Score =  286 bits (733), Expect = 4e-76,   Method: Composition-based stats.
 Identities = 70/231 (30%), Positives = 107/231 (46%), Gaps = 20/231 (8%)

Query: 8   PPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP---------QAE 58
           P  +  L ++Y+D  ++V++K   +   PG   EH       + R            +  
Sbjct: 76  PNYDIDLKVVYEDHDVIVIDKDPYIAVHPGNGIEHHTITNALLARFGAGLQSVGSSSRPG 135

Query: 59  SVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICD 118
            VHRLD  TSG++V A T+ A   L  +   +  KK+Y+A  WG P P  G++   +   
Sbjct: 136 IVHRLDKDTSGLMVAAKTENAYYRLSEELANQGFKKEYLAVAWGIPCPKRGVIHTNIRVK 195

Query: 119 WPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGD 178
             +    +     GKPA+TEYEV +   +  + +     TGR+HQ+RVHM  +GH I+GD
Sbjct: 196 RSDITMMEAANSGGKPAKTEYEVEQELGEVASLIRCTLHTGRTHQIRVHMSHIGHSIVGD 255

Query: 179 RFYAS----------PEARAMAPRLLLHAEMLTITHPAYGNSMTFKA-PAD 218
           + Y            P       R  LHA +L   HP+ G  + F + PAD
Sbjct: 256 QKYGKNCKKCMRSGVPPDVKNFRRQALHASLLGFRHPSTGKYIEFTSKPAD 306


>UniRef50_Q2NIN6 Pseudouridine synthase n=4 Tax=Candidatus Phytoplasma
           RepID=Q2NIN6_AYWBP
          Length = 306

 Score =  286 bits (733), Expect = 4e-76,   Method: Composition-based stats.
 Identities = 66/222 (29%), Positives = 110/222 (49%), Gaps = 13/222 (5%)

Query: 5   NYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDY--------PQ 56
           N   PQ   L I+Y+D ++ V+NKP+ L+  P  L   K +++  +   +         +
Sbjct: 73  NLQTPQNLNLDIIYEDPYLAVINKPANLVVHPS-LSFQKTTLVNGLLHQFNTLSHIDTQR 131

Query: 57  AESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLI 116
              VHRLD  T+G+++VA T     +L+  F++R+  K Y A + G     +G++ LP+ 
Sbjct: 132 PGIVHRLDKNTTGLLIVAKTNDVSDKLQIAFQQRKITKIYWALIEG-FLEDKGIIKLPIG 190

Query: 117 CDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPIL 176
            +  NR K +V    GK A T ++ ++    + + +     TGR+HQLR H   L HPI+
Sbjct: 191 RNNHNRLKMQV-MPDGKTAVTHFKTLQRF-SHFSLMECNLETGRTHQLRAHFSFLKHPIV 248

Query: 177 GDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           GD  Y S           LH+++L   HP    ++  +AP  
Sbjct: 249 GDLLYDSSHHITPL-GQFLHSKILKFNHPITNQNLILEAPLP 289


>UniRef50_A5IBH6 Pseudouridine synthase n=6 Tax=Legionella RepID=A5IBH6_LEGPC
          Length = 321

 Score =  285 bits (732), Expect = 5e-76,   Method: Composition-based stats.
 Identities = 70/234 (29%), Positives = 109/234 (46%), Gaps = 22/234 (9%)

Query: 5   NYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR-----DYPQAES 59
           N   P+   + I+Y+D  ++VVNKP+GL+  PG   +    V   +         P+A  
Sbjct: 78  NLCKPENIPIQIIYEDSEVIVVNKPAGLVVHPGAGNKEHTLVNALLHHCPELQLLPRAGI 137

Query: 60  VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDW 119
           +HRLD  T+G+++VA    +   L RQ + RE K+ Y+  V G+     G +D       
Sbjct: 138 IHRLDKDTTGLLIVAKNLISHTSLIRQMQNREIKRHYLTLVHGYVISG-GTIDTGFGRHP 196

Query: 120 PNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDR 179
            NR K  V  + G+ A T Y + ++  D    + +  +TGR+HQ+RVHM  + HP++GD+
Sbjct: 197 KNRLKMAV-TDFGRQAVTHYNINKHYKD-FTLLNVSLMTGRTHQIRVHMNYINHPVVGDQ 254

Query: 180 FYASPEARAM------------APRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
            Y                      R  LHA  ++  HP     +T  A  P DF
Sbjct: 255 LYGGRMKFPPNADEAILSVLKQFKRQALHACSISFCHPVKNTEITLNALLPDDF 308


>UniRef50_Q1J0S8 Pseudouridine synthase n=7 Tax=Deinococci RepID=Q1J0S8_DEIGD
          Length = 341

 Score =  285 bits (732), Expect = 5e-76,   Method: Composition-based stats.
 Identities = 79/228 (34%), Positives = 109/228 (47%), Gaps = 21/228 (9%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR------------DYPQ 56
           P+   L +LY+D+H++ VNKP G+++ P         V   + R            D  +
Sbjct: 92  PEAVPLDVLYEDEHLIAVNKPPGMVTHPAPGVTSGTLVNALLGRLTLPEQPGAVGPDGYR 151

Query: 57  AESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEG--LVDLP 114
              VHRLD  TSGVIVVA T  A   L   F++R   K Y+A   G     +G   V+ P
Sbjct: 152 PGIVHRLDKDTSGVIVVAKTVEAHARLAAAFKDRSTHKTYLAIAAGMWKA-QGPVSVNAP 210

Query: 115 LICDWPNRPKQKVCYETGKPAQTEYEVVEYAADN----TARVVLKPITGRSHQLRVHMLA 170
           +      R +  V     + AQT +  +    D      A V  +P TGR+HQ+RVH+  
Sbjct: 211 VGRHPTARQRMTVGGVGPREAQTLFTPLATHPDGHGRTLALVRAQPHTGRTHQIRVHLAH 270

Query: 171 LGHPILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           LG PILGD  Y    A A+ PR  LHA+ LT+ HP  G ++   AP  
Sbjct: 271 LGSPILGDAVYG--RASAVMPRHALHAQFLTLPHPVTGETLHLHAPVP 316


>UniRef50_UPI00016C3FBA ribosomal large subunit pseudouridine synthase n=1 Tax=Gemmata
           obscuriglobus UQM 2246 RepID=UPI00016C3FBA
          Length = 354

 Score =  285 bits (731), Expect = 7e-76,   Method: Composition-based stats.
 Identities = 72/235 (30%), Positives = 103/235 (43%), Gaps = 26/235 (11%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR---------DYPQAES 59
           P++  L ILYQD+ + +VNKP+ ++  P +       V                + +A  
Sbjct: 104 PEDIPLDILYQDEWLALVNKPADMVVHPAKGNWSGTLVNALQWHFREHLSTGAGHLRAGI 163

Query: 60  VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDW 119
           VHRLD  TSGVI+VA      R+L  QF  R+  K+YVA   G        ++  L    
Sbjct: 164 VHRLDKDTSGVILVAKDDLTHRDLAMQFESRKVFKEYVAIAAGELERDSDYIEGALKMHP 223

Query: 120 PNRPKQKVC-YETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGD 178
            +R K  V      K A + YEV+E        V ++P TGR+HQ+RVH+L +G  +L D
Sbjct: 224 YDRLKMIVSTDPDAKHALSYYEVLERFR-GFTLVKVQPRTGRTHQIRVHLLHVGCAVLAD 282

Query: 179 RFYASP---------------EARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           + Y                  E   +  R  LHA  L   HP  G  +  +AP  
Sbjct: 283 KIYGGRAQVKLSEIAPGTPPAEDEVLLGRQALHAFRLRFQHPRTGQWIEAEAPLP 337


>UniRef50_Q2CAH0 Pseudouridine synthase n=3 Tax=Proteobacteria RepID=Q2CAH0_9RHOB
          Length = 215

 Score =  285 bits (731), Expect = 7e-76,   Method: Composition-based stats.
 Identities = 117/217 (53%), Positives = 146/217 (67%), Gaps = 2/217 (0%)

Query: 3   MENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHR 62
           M +   P +  L +L++D  +++V+KP+GLLSVPG+ E   D ++ R+Q  +P A  VHR
Sbjct: 1   MSSDYDPPDVPLAVLHEDHEVVLVDKPAGLLSVPGKGEHLADCLLARVQAAFPTALLVHR 60

Query: 63  LDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNR 122
           LD  TSGV++ ALT  A+R L  QF +R+ +K YVARV G  +   G VDLPLI DWPNR
Sbjct: 61  LDRDTSGVMIFALTPHAQRHLGLQFEKRQTRKTYVARVAGRIADKTGTVDLPLIVDWPNR 120

Query: 123 PKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYA 182
           PKQ V +E GKPA T++ VV  A+D   RV L P TGRSHQLRVHMLALGHPILGD FYA
Sbjct: 121 PKQMVDHENGKPAVTDWRVV-RASDAETRVRLFPKTGRSHQLRVHMLALGHPILGDPFYA 179

Query: 183 SPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
              ARA  PR++LH+E L   HP  G  M   APA F
Sbjct: 180 EGPARAH-PRMMLHSETLQFRHPDGGRGMRITAPAPF 215


>UniRef50_B8CWB7 Pseudouridine synthase n=1 Tax=Halothermothrix orenii H 168
           RepID=B8CWB7_HALOH
          Length = 310

 Score =  285 bits (731), Expect = 7e-76,   Method: Composition-based stats.
 Identities = 67/222 (30%), Positives = 112/222 (50%), Gaps = 8/222 (3%)

Query: 2   GMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ----- 56
             + Y  P    L I+Y+D H++V+NKP+ +L  P  +E+    V   +     Q     
Sbjct: 81  KEKTYYDPAPLDLDIIYEDRHLLVINKPANMLVHPTPVEKSNTIVNGVLYHMRNQGNYNL 140

Query: 57  AESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLI 116
              +HRLD  T+G++++A  + A   +  QF+     ++Y+A V G+    +  ++ P+ 
Sbjct: 141 VRPIHRLDRNTTGLLLIAKNQYAHNYITHQFQNNNIHREYLAFVHGNVEFKKESINAPIG 200

Query: 117 CDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPIL 176
               +  K+KV +  GK A T  +VV+      + + +K  TGR+HQ+RVH+  LGHP+L
Sbjct: 201 KTRDSLIKRKVDHTLGKRAVTHIKVVK-PGGLISLIRVKLETGRTHQIRVHLSHLGHPLL 259

Query: 177 GDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           GD  Y   +   +  R  LH+  +T   P     +TFKAP  
Sbjct: 260 GDTLYGGEDI--LIKRPALHSYKVTCCLPFKHKEVTFKAPLP 299


>UniRef50_B3DV48 Pseudouridine synthase n=1 Tax=Methylacidiphilum infernorum V4
           RepID=B3DV48_METI4
          Length = 325

 Score =  285 bits (730), Expect = 9e-76,   Method: Composition-based stats.
 Identities = 68/225 (30%), Positives = 108/225 (48%), Gaps = 10/225 (4%)

Query: 2   GMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP------ 55
            + +    +E  L ILY+D+ I++VNK  G++  P         V + +           
Sbjct: 79  EIPSLPKAEEIALEILYEDEEILIVNKQRGMVVHPSCGHWSGTLVNSLLFHYGESLPGSS 138

Query: 56  --QAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDL 113
             +   VHRLD  TSGV+V+A T+ + + L  QF +R  +K Y+              + 
Sbjct: 139 LLRPGIVHRLDKDTSGVMVIAKTERSLKSLLLQFSQRTVQKVYLCLCKNRFPYLRYSFEA 198

Query: 114 PLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGH 173
            +     +R K  V    GK A+T + ++ +A+   + +  +P++GR+HQ+RVH+  LG 
Sbjct: 199 NIHRHASDRKKMAVHRLKGKTAETRFTLL-FASSQASFLKCEPVSGRTHQIRVHLSHLGF 257

Query: 174 PILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           PI+GD  Y     +   P LLLHA  L I HP  G  + F AP  
Sbjct: 258 PIIGDPLYGKGVRKYPFP-LLLHAYALKIEHPRSGKKIEFMAPLP 301


>UniRef50_B6J6C4 Pseudouridine synthase n=7 Tax=Coxiella burnetii RepID=B6J6C4_COXB1
          Length = 327

 Score =  285 bits (730), Expect = 1e-75,   Method: Composition-based stats.
 Identities = 65/227 (28%), Positives = 107/227 (47%), Gaps = 20/227 (8%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRD-----YPQAESVHRL 63
           PQ   L ++Y+D+ ++V+NKP GL+  PG     +  +   +  D      P+A  +HRL
Sbjct: 84  PQPIPLDVIYEDETLLVINKPVGLIVHPGAGVRDQTLINALLHYDPSLSVVPRAGIIHRL 143

Query: 64  DMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRP 123
           D  TSG++++A T A+   L +  + R+  ++Y A V G        ++ P+     +R 
Sbjct: 144 DKDTSGLLLIARTLASHHALIKAMKARQIVREYEAIVKGVLISGR-TIEAPVGRHPIHRT 202

Query: 124 KQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYAS 183
           +  V  E G+PA T + +++    +   + ++  TGR+HQ+RVHM  + HP+ GD  Y S
Sbjct: 203 RMAVV-EFGRPAITHFRIIKRYRAH-THIRVQLETGRTHQIRVHMAHIHHPLAGDPVYGS 260

Query: 184 P------------EARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
                         A     R  LH   L  +HP     M   AP  
Sbjct: 261 HVGIPVHLSDPLQTALKTLKRQALHGATLQFSHPVDQRPMACHAPLP 307


>UniRef50_A1HR26 Pseudouridine synthase, RluA family n=1 Tax=Thermosinus
           carboxydivorans Nor1 RepID=A1HR26_9FIRM
          Length = 301

 Score =  284 bits (729), Expect = 1e-75,   Method: Composition-based stats.
 Identities = 69/222 (31%), Positives = 108/222 (48%), Gaps = 10/222 (4%)

Query: 2   GMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ----- 56
           G ++   P +  L I+Y+DD +++VNKP+GLL  P             +   + +     
Sbjct: 63  GDDSCLTPMKMPLHIVYEDDFLLIVNKPAGLLVHPTSDPTEPTLAHGILYYLHSKGALGA 122

Query: 57  AESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLI 116
              +HRLD  TSG++ +A     +  L     +   K+ Y+A V G PS   G +D P+ 
Sbjct: 123 FHPIHRLDRNTSGLVAIAKHPHIQHALSGGGAKG-LKRLYLAVVTGIPSSLMGRIDAPIG 181

Query: 117 CDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPIL 176
               +  K+ V    G+PA T Y V+   +   + V L+ +TGR+HQ+RVH+  +GHP+L
Sbjct: 182 RHPNSIIKR-VVRSDGQPAITLYRVLSTFSM-ASLVELELLTGRTHQIRVHLSHIGHPLL 239

Query: 177 GDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           GD  Y       +  R  LHA  L+  HPA    +T  +P  
Sbjct: 240 GDDLYGGATD--LIRRQALHAASLSFRHPATDKVLTLTSPLP 279


>UniRef50_D1N7N8 Pseudouridine synthase, RluA family n=1 Tax=Victivallis vadensis
           ATCC BAA-548 RepID=D1N7N8_9BACT
          Length = 323

 Score =  284 bits (729), Expect = 1e-75,   Method: Composition-based stats.
 Identities = 76/221 (34%), Positives = 104/221 (47%), Gaps = 16/221 (7%)

Query: 13  WLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP----------QAESVHR 62
              ILY+DD ++V++KP+G++  P         V   + R             +   VHR
Sbjct: 82  EFPILYEDDVMLVIDKPAGVVVHPAAGNPTGTVVNALLGRYPQLAEQLACTTSRPGIVHR 141

Query: 63  LDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNR 122
           LD  TSG + VA T  A+ +L   F  RE +K Y+A   G P    G +   +     +R
Sbjct: 142 LDKDTSGCLAVAKTANAQFKLSTAFAGRETRKTYLAITRGVPIRRSGELSTLIGRHPVSR 201

Query: 123 PKQKVCYETGKPAQTEYEVVEYAAD----NTARVVLKPITGRSHQLRVHMLALGHPILGD 178
            K  V    GK A T Y V EY           + ++ +TGR+HQ+RVH+ +LG P+LGD
Sbjct: 202 QKMAVVERNGKLAITRYRV-EYTGMLDGVEIGVLAVRILTGRTHQIRVHLASLGVPVLGD 260

Query: 179 RFYAS-PEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
             Y     A A   R LLHA  L + HPA G  M F AP  
Sbjct: 261 AVYGGARTAVAGVERQLLHAWKLCVPHPATGTPMEFTAPPP 301


>UniRef50_C0GNZ6 Pseudouridine synthase, RluA family n=1 Tax=Desulfonatronospira
           thiodismutans ASO3-1 RepID=C0GNZ6_9DELT
          Length = 535

 Score =  284 bits (729), Expect = 1e-75,   Method: Composition-based stats.
 Identities = 76/239 (31%), Positives = 113/239 (47%), Gaps = 22/239 (9%)

Query: 2   GMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------D 53
                  P    L I+Y D  ++V+NKP+GL   P   +     V   +          D
Sbjct: 71  EENEDLEPVAGKLDIVYMDREMVVLNKPAGLSVHPSSSDPAPTLVHYLLYACPGLRLMTD 130

Query: 54  YPQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDL 113
             +   VHRLD  T+G++V AL + A+ +L  QF  R   K Y+A V G     EG++++
Sbjct: 131 RQRPGIVHRLDKDTTGLMVAALNQEAKEDLAGQFAGRRVHKTYLALVCGALKQDEGIINV 190

Query: 114 PLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADN-TARVVLKPITGRSHQLRVHMLALG 172
           PL  D  +R +     E G+ A+T Y+V++       + V ++  TGR+HQ+RVH   L 
Sbjct: 191 PLARDQQSRARVAPSRE-GRSARTAYKVLKRDPSGLWSLVQVQIFTGRTHQIRVHFSHLN 249

Query: 173 HPILGDRFYASPEAR----------AMAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
           HP+LGDR Y   +             +A R LLH+  L I HP     + F +  P DF
Sbjct: 250 HPVLGDRIYGGTDWDRFGWKKRFLSRLAKRQLLHSSCLGIMHPVSRQWLEFISRPPRDF 308


>UniRef50_C5J6Q2 Pseudouridine synthase n=1 Tax=Mycoplasma conjunctivae HRC/581
           RepID=C5J6Q2_MYCCR
          Length = 306

 Score =  284 bits (728), Expect = 2e-75,   Method: Composition-based stats.
 Identities = 71/234 (30%), Positives = 105/234 (44%), Gaps = 22/234 (9%)

Query: 3   MENYNPPQ------EPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR---- 52
           + NY  PQ      +    I+YQD+ I+V+NKP  L+  PG     K  V   +      
Sbjct: 65  LNNYQEPQLKVEAQKVDFEIVYQDNDIIVINKPKNLVVHPGNGNWDKTLVNGLLHEFATN 124

Query: 53  -----DYPQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPA 107
                   +   VHRLD  TSG+++VA    A + L +Q    E +++Y+A V G     
Sbjct: 125 LSDVNGEIRPGIVHRLDKDTSGLLLVAKNNQAHKYLAKQLENHEIERKYIAIVVGKIPHT 184

Query: 108 EGLVDLPLICDWPNRPKQKVCYETGKPAQTEYEVVEYA---ADNTARVVLKPITGRSHQL 164
           +  ++LP+  D  NR K+ V     K A T  E++       ++ + V     TGR+HQ+
Sbjct: 185 KMRINLPIGRDNQNRTKKVVSSFNSKNAITNVELINTFVYKNEHFSIVKCILETGRTHQI 244

Query: 165 RVHMLALGHPILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           RVH+  +G+PI GD  Y             LHA  +T  H   G  M FK    
Sbjct: 245 RVHLSHIGYPIYGDPVYGKKIDDLG---QRLHAYEITFKH-LDGRLMNFKTEMP 294


>UniRef50_D1AV01 Pseudouridine synthase n=2 Tax=Bacteria RepID=D1AV01_STRM9
          Length = 297

 Score =  283 bits (727), Expect = 2e-75,   Method: Composition-based stats.
 Identities = 59/205 (28%), Positives = 99/205 (48%), Gaps = 13/205 (6%)

Query: 17  LYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYPQAESVHRLDMATS 68
           +Y+D ++ ++NK +G++  P +  E    V   + +           +   VHRLD  TS
Sbjct: 78  VYEDKYLAIINKYAGMVVHPSKGHEEDTLVNAIMYKIKDLSGINGDLRPGIVHRLDKNTS 137

Query: 69  GVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVC 128
           G+I++A       +L   F+ +E KK Y A V G  +   G ++  +  +  +R K  V 
Sbjct: 138 GLIIIAKDDKTHFKLSEMFKNKEIKKIYYAIVKGKVNKKSGRIETMIGRNPNDRKKMAVV 197

Query: 129 YETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARA 188
            + GK A T +EV++ + +  + + +   TGR+HQ+RVH+     PILGD  Y   +   
Sbjct: 198 -DNGKLAITNFEVID-SNEKFSLLKVDLETGRTHQIRVHLSHFFFPILGDSVYGRKDEY- 254

Query: 189 MAPRLLLHAEMLTITHPAYGNSMTF 213
              R +LHA ML   HP     +  
Sbjct: 255 --DRQMLHAYMLNFIHPITLEKIDV 277


>UniRef50_A4RT55 Predicted protein (Fragment) n=3 Tax=Chlorophyta RepID=A4RT55_OSTLU
          Length = 332

 Score =  283 bits (727), Expect = 2e-75,   Method: Composition-based stats.
 Identities = 78/270 (28%), Positives = 118/270 (43%), Gaps = 58/270 (21%)

Query: 8   PPQE-PWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR-------------- 52
            P+    L I+++D+ ++VVNK +G+++ P    E    V   +                
Sbjct: 63  KPEPWVKLDIVHEDESVLVVNKAAGMVTHPSAGHESGTLVNAVLGHCDLPELVVPTGNQA 122

Query: 53  --------------------DYPQAESVHRLDMATSGVIVVALTKAAERELKRQFREREP 92
                                  +   VHRLD  TSGV+VVA   +A   L  QF  R  
Sbjct: 123 LSDDDEDDEDAVDEDEGARDGMIRPGIVHRLDKGTSGVMVVAKDASAHNSLCEQFAARVV 182

Query: 93  KKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYETGKPAQTEYEVVEYAAD-NTAR 151
           +++YVA + G PSP++G ++ P+  D  +R +  V    G+ A + YEV+   A+ N + 
Sbjct: 183 RRKYVAILSGVPSPSKGRIEAPIGRDPRDRLRMAVTQGGGRFAASNYEVIATLANGNASL 242

Query: 152 VVLKPITGRSHQLRVHMLALGHPILGDRFYA--------------------SPEARAMAP 191
           V  +  TGR+HQ+RVH   +GHPILGD  Y                     +    +   
Sbjct: 243 VEWRLETGRTHQIRVHAKHIGHPILGDDTYGGGGGAAVSALSRYGVFDVKEAKALMSTID 302

Query: 192 RLLLHAEMLTITHPAYGNSMTFK--APADF 219
           R +LHA  L  THP  G ++ F    P DF
Sbjct: 303 RPMLHARTLGFTHPQSGEALDFSRDPPEDF 332


>UniRef50_C8X1I9 Pseudouridine synthase, RluA family n=1 Tax=Desulfohalobium
           retbaense DSM 5692 RepID=C8X1I9_DESRD
          Length = 547

 Score =  283 bits (726), Expect = 3e-75,   Method: Composition-based stats.
 Identities = 73/235 (31%), Positives = 111/235 (47%), Gaps = 19/235 (8%)

Query: 2   GMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRI-------QRDY 54
            +++   P+   + ++Y D  ++VVNK +G+   PG   E    V           + D 
Sbjct: 79  SLQSGIKPEVGPVEVVYSDPDVVVVNKAAGVTVHPGTGCESGTLVHHLAALYPELARFDG 138

Query: 55  PQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLP 114
            +   VHRLD  TSG++ VAL ++A   L R F  RE  K+Y+  V G P  AEG VD P
Sbjct: 139 ERPGVVHRLDKDTSGLLTVALNESARLALTRSFARREVDKEYLTLVHGRP-EAEGTVDHP 197

Query: 115 LICDWPNRPKQKVCYETGKPAQTEYEVVEYAAD-NTARVVLKPITGRSHQLRVHMLALGH 173
           L  D  ++ +  V    GK A T ++ V  + D   + + ++ +TGR+HQ+RVHM  LG 
Sbjct: 198 LGRDPQSKIRMAVVPRGGKEALTRFKRVWTSPDGRVSLLRVRILTGRTHQIRVHMAYLGF 257

Query: 174 PILGDRFYASPEA----------RAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           P++GD  Y                 +A   +LHA  L   HP  G  +  +    
Sbjct: 258 PLVGDALYGPQAQAAFQRSRPLLARLAKHHMLHAWRLAFPHPRSGRMVCCEQAMP 312


>UniRef50_A8MF48 Pseudouridine synthase n=12 Tax=Clostridiaceae RepID=A8MF48_ALKOO
          Length = 305

 Score =  283 bits (725), Expect = 3e-75,   Method: Composition-based stats.
 Identities = 70/224 (31%), Positives = 111/224 (49%), Gaps = 9/224 (4%)

Query: 1   MGME-NYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ--- 56
           M  E N+   Q+     +Y+D  +++VNK  G+++ P +                 +   
Sbjct: 72  MEDEPNHFTLQDVPFEAVYEDVDLILVNKEPGIVTHPTKSHPDWTIANGAALYLKSKGID 131

Query: 57  --AESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLP 114
                V+RLDM TSG++++A    A   L  Q +E   +K+Y+A VWG     EG ++ P
Sbjct: 132 CKVRFVNRLDMDTSGLLIIAKNAYAHHVLSEQMQEDRIEKKYIAFVWGVIKEDEGRIEAP 191

Query: 115 LICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHP 174
           +     +  K+ V  E G+ + TE++V+E    N   V +K +TGR+HQ+RVHM  LGHP
Sbjct: 192 IYRTTMDSIKR-VVDERGQESITEFKVLERYK-NATMVEVKLLTGRTHQIRVHMEHLGHP 249

Query: 175 ILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           ++GD  Y   E   +  R  LHAE L    P +  ++  KA   
Sbjct: 250 LIGDTLYG-KEDAELIDRQALHAEYLRFWQPRFKRAIEVKADLP 292


>UniRef50_Q489H0 Pseudouridine synthase n=3 Tax=Gammaproteobacteria
           RepID=Q489H0_COLP3
          Length = 567

 Score =  282 bits (724), Expect = 5e-75,   Method: Composition-based stats.
 Identities = 101/229 (44%), Positives = 145/229 (63%), Gaps = 18/229 (7%)

Query: 1   MGMENY----NPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ 56
           M ++      NP +   L I++QD+H++VVNKP+GLLSVPG+  +  DSV TRI+  +PQ
Sbjct: 347 MEVDKNPLLINPAEGIDLEIVFQDEHVVVVNKPAGLLSVPGKSIK--DSVYTRIKTQFPQ 404

Query: 57  AE---SVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDL 113
           A     VHRLDMATSG++++AL + A + L++QF  +E  K+YVA + G      G + L
Sbjct: 405 ASGGLIVHRLDMATSGLLMLALNERAHKHLQQQFMNKEINKRYVATIEGKLEKTSGEICL 464

Query: 114 PLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLA--- 170
           PL  D+ +RPKQ VC+E GK A+T ++++E   DNT+++ L PITGR+HQLR+H      
Sbjct: 465 PLRGDFDDRPKQMVCHEHGKYAETHWQLIEEV-DNTSKLFLYPITGRTHQLRMHCAHPDG 523

Query: 171 LGHPILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
           L  PI+GD  Y        A RL LHA+ L+ THP     +TF+   +F
Sbjct: 524 LNLPIIGDSLYGHS-----ADRLHLHAQRLSFTHPITKELLTFEVAENF 567


>UniRef50_B0K860 Pseudouridine synthase n=11 Tax=Thermoanaerobacterales
           RepID=B0K860_THEP3
          Length = 285

 Score =  282 bits (724), Expect = 5e-75,   Method: Composition-based stats.
 Identities = 66/223 (29%), Positives = 110/223 (49%), Gaps = 15/223 (6%)

Query: 2   GMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ----- 56
             ++   P++  L I Y+D+ I++VNKP+ ++  P +  +    +   +   + +     
Sbjct: 62  ENDSNIAPEKLDLDICYEDEEILIVNKPANMVVHPTKRYQSGT-LANGVAWYFKEKGLKA 120

Query: 57  -AESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPL 115
               V+RLD  TSG++V A     +  L+     +   K Y A V G     EG +DLP+
Sbjct: 121 LIRPVNRLDRGTSGLVVFAKRPFMQYYLQII---KPMTKLYFAVVEGKM-EGEGRIDLPI 176

Query: 116 ICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPI 175
                +  ++ V  E G  A T Y+VV+ ++   + + +K  TGR+HQ+RVH+  +GHPI
Sbjct: 177 SRKPQSGIERMV-SEEGDRAITNYKVVK-SSKRFSLLKVKIETGRTHQIRVHLSHIGHPI 234

Query: 176 LGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           +GD  Y S +      R  LHA  LT  HP    S++  +P  
Sbjct: 235 VGDTLYGSSDD--YIKRQALHAYRLTFVHPLEEKSISVYSPLP 275


>UniRef50_C2W5F3 Pseudouridine synthase n=4 Tax=Bacillus RepID=C2W5F3_BACCE
          Length = 307

 Score =  282 bits (723), Expect = 6e-75,   Method: Composition-based stats.
 Identities = 63/224 (28%), Positives = 104/224 (46%), Gaps = 11/224 (4%)

Query: 2   GMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP------ 55
             E    P+   L ++++DDH+++VNKP+ + + P         +   +           
Sbjct: 73  QEEYGVQPEYGDLEVIFEDDHVLIVNKPAHMDTHPSNKGGTGT-LANLVAFHLQMQGVET 131

Query: 56  QAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPL 115
           +   +HRLD  T+G +V A    A   + R   ER  K+ Y+A V G     +G++D  +
Sbjct: 132 KVRHIHRLDKDTTGGVVFAKHGIAGVIMDRLLMERNIKRTYLALVEGKVRKKQGIIDEAI 191

Query: 116 ICDWPNRPKQKVCYETGKPAQTEYEVVEYA-ADNTARVVLKPITGRSHQLRVHMLALGHP 174
             D  +  +++V  + G  A T Y++ +Y    +   V L+  TGR+HQ+RVHM   GHP
Sbjct: 192 GRDRHHATRRRV-SQKGDRAVTHYKIEKYFKKQDVTLVTLQLETGRTHQIRVHMSHSGHP 250

Query: 175 ILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           ++GD  Y         P   LHA  +   HP     +T +AP  
Sbjct: 251 LIGDVLYGG--QATYMPYQALHAMRIHFLHPITKEEITVEAPLP 292


>UniRef50_Q14NK8 Probable pseudouridine synthase d protein n=1 Tax=Spiroplasma citri
           RepID=Q14NK8_SPICI
          Length = 306

 Score =  282 bits (723), Expect = 6e-75,   Method: Composition-based stats.
 Identities = 61/220 (27%), Positives = 103/220 (46%), Gaps = 9/220 (4%)

Query: 7   NPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRD--------YPQAE 58
             P    L ILY+D ++MV++KP+ L+  P    ++   V   + R           +  
Sbjct: 74  LTPLAIPLTILYEDSYLMVIDKPNNLVVHPAPGHQNDTLVNALLARGVQWSTASGEQRPG 133

Query: 59  SVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICD 118
            VHR+D  T+G +++A       +L++Q + ++ +++Y+A V G        +D P+  D
Sbjct: 134 IVHRIDRQTTGTLIIAKNDVVHHQLQQQIQTKQLQRRYLALVHGQIIENRAKIDAPIGRD 193

Query: 119 WPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGD 178
             NR K  V  +  K A T   V+E   D    +  +  +GR+HQ+R H+  + HPI+GD
Sbjct: 194 PNNRKKMVVTAKNSKKALTNIVVIERFND-YTYIECELESGRTHQIRAHLKYINHPIVGD 252

Query: 179 RFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
             Y +   +  +    LHA  L   HP    S+T  A   
Sbjct: 253 PLYGTVADKKESFGQYLHAYQLRFIHPVTKESLTITAALP 292


>UniRef50_C0ZCK6 Pseudouridine synthase n=1 Tax=Brevibacillus brevis NBRC 100599
           RepID=C0ZCK6_BREBN
          Length = 302

 Score =  282 bits (722), Expect = 8e-75,   Method: Composition-based stats.
 Identities = 74/210 (35%), Positives = 102/210 (48%), Gaps = 11/210 (5%)

Query: 15  VILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ------AESVHRLDMATS 68
            ILY+DDH+++VNKP GLL  P     H   +   +   + +         VHRLD  TS
Sbjct: 87  EILYEDDHLLIVNKPVGLLLHPTERYHHVT-LDHLVSGHFFRTGLEAKVRHVHRLDQDTS 145

Query: 69  GVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVC 128
           GV++ A    A   L    RER  K+ YVA V G      G ++ P+  D  +  +++V 
Sbjct: 146 GVVLYAKHPWASALLDEMLRERTIKRTYVAYVSGQMPKERGKINEPIGKDRNHGTRRRV- 204

Query: 129 YETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARA 188
              G PA T Y+V E       +V  +  TGR+HQ+RVH   +GHP+LGD  Y     R 
Sbjct: 205 TPNGDPAITHYQVKERF-QTATKVECQLETGRTHQIRVHFSHIGHPLLGDELYGGK--RE 261

Query: 189 MAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           +  R  LHA +L   HP  G  +   AP  
Sbjct: 262 LIKRQALHAAVLKFEHPFGGEVIEVTAPLP 291


>UniRef50_A4VJG2 Pseudouridine synthase n=18 Tax=Bacteria RepID=A4VJG2_PSEU5
          Length = 244

 Score =  281 bits (721), Expect = 1e-74,   Method: Composition-based stats.
 Identities = 106/207 (51%), Positives = 141/207 (68%), Gaps = 2/207 (0%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR-DYPQAESVHRLDMATSGVIV 72
           + I++QD  ++V++KP+ LLSVPGR E+++D ++TR+Q   YP+A  VHRLD  TSG+IV
Sbjct: 39  IQIVHQDAALLVIDKPTLLLSVPGRAEDNRDCLVTRLQENGYPEARIVHRLDWETSGLIV 98

Query: 73  VALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYETG 132
           +A    + REL RQF +RE +K Y A  WG P    G +DLPL  D P +P+  V  E G
Sbjct: 99  LARDADSHRELSRQFHDRETEKAYTALCWGQPDADSGSIDLPLRYDPPTKPRHVVDPELG 158

Query: 133 KPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARAMAPR 192
           K A T + V+E   D+ +RV L PITGRSHQLRVHML++GHP+LGDR YA  +A     R
Sbjct: 159 KHALTFWRVLERCGDH-SRVELTPITGRSHQLRVHMLSIGHPLLGDRLYAHEQALRAHER 217

Query: 193 LLLHAEMLTITHPAYGNSMTFKAPADF 219
           L LHA MLT+THP  G  + F++PA F
Sbjct: 218 LCLHASMLTLTHPQTGARLRFESPAPF 244


>UniRef50_Q6MGX8 Pseudouridine synthase n=1 Tax=Bdellovibrio bacteriovorus
           RepID=Q6MGX8_BDEBA
          Length = 319

 Score =  281 bits (720), Expect = 1e-74,   Method: Composition-based stats.
 Identities = 74/246 (30%), Positives = 99/246 (40%), Gaps = 35/246 (14%)

Query: 3   MENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DY 54
                 P +  L +L++D+ ++V+NKP+GL+  P     H   V   I            
Sbjct: 58  EPTELQPFDLKLDVLFEDEDLIVINKPAGLVVHPAAGHAHDTLVNALIHHTDDLSMKFGE 117

Query: 55  PQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLP 114
            +   VHRLD  TSG+IV+A    A   L  QF+ER   + Y A   G      G V   
Sbjct: 118 ERPGIVHRLDKETSGIIVIAKNDKAHESLTSQFKERSTHRIYYAVCLGTARTLSGSVRSF 177

Query: 115 LICDWPNRPKQKVCYET--------------GKPAQTEYEVVEYAADNTARVVLKPITGR 160
           L     +R +                     GK A T +EV++      + + LK  TGR
Sbjct: 178 LARHPVDRKRYASVLGDDRKPLTDPNDDPGLGKWAVTHFEVLQR-KSGMSYLKLKLETGR 236

Query: 161 SHQLRVHMLALGHPILGDRFYASP------------EARAMAPRLLLHAEMLTITHPAYG 208
           +HQ+RVHM   G PI GD  Y +             E     PR LLHA  L  THP   
Sbjct: 237 THQIRVHMSESGLPIAGDTLYGADRKIKSIEARATQEDLRTLPRFLLHAAELGFTHPRTK 296

Query: 209 NSMTFK 214
             M F 
Sbjct: 297 ERMFFT 302


>UniRef50_A5VJ18 Pseudouridine synthase, RluA family n=13 Tax=Lactobacillus
           RepID=A5VJ18_LACRD
          Length = 301

 Score =  281 bits (720), Expect = 1e-74,   Method: Composition-based stats.
 Identities = 68/229 (29%), Positives = 109/229 (47%), Gaps = 20/229 (8%)

Query: 6   YNPPQ---------EPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ 56
             PP+         E  + I+Y+D   +++NKP+G+ +VP       DS++ R++  Y +
Sbjct: 61  ILPPETANDNVDVSEAPIDIIYEDQDFLIMNKPAGVATVPAHNVPVADSLVNRVKGYYKR 120

Query: 57  A-------ESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEG 109
                       RLD  TSG++V    + A   L  Q ++   KK Y+A + G      G
Sbjct: 121 QNYENQVTHVATRLDRDTSGLVVFPKHRFAHAVLDEQLKKHLVKKNYLALIKGKVPAEHG 180

Query: 110 LVDLPLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHML 169
            +D P+  D  +  K+ V  E GK + TEY   E      + + ++  TGR+HQ+RVH  
Sbjct: 181 YIDAPIQRDPNSFVKRMVGKE-GKASVTEYWRQECNVQ-ASLIKIRLHTGRTHQIRVHFA 238

Query: 170 ALGHPILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           +LG P++GD+ Y   E   +  R  LH   L+   P  G ++T  AP  
Sbjct: 239 SLGFPLIGDKMYG--EESGLIARQALHCYWLSFYSPFKGKNITVSAPLP 285


>UniRef50_C7LVL1 Pseudouridine synthase n=5 Tax=Proteobacteria RepID=C7LVL1_DESBD
          Length = 234

 Score =  280 bits (719), Expect = 2e-74,   Method: Composition-based stats.
 Identities = 117/214 (54%), Positives = 152/214 (71%), Gaps = 4/214 (1%)

Query: 6   YNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDM 65
           Y+PP EP L ++++D  ++VVNKPSGLLSVPGR  E  DSV++R++  +  A++VHRLD+
Sbjct: 8   YDPPTEPRLAVIHEDRDMVVVNKPSGLLSVPGRTPELFDSVLSRVREIHRGAQAVHRLDL 67

Query: 66  ATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQ 125
            TSGV+VVA  + AE  L++QF++R  +K Y+ARV G  S   G VDLPLICDWPNRP Q
Sbjct: 68  GTSGVLVVATRRKAETILRQQFQDRLTRKLYLARVQGVMSEDSGQVDLPLICDWPNRPMQ 127

Query: 126 KVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPE 185
            VC++TGKPA T+Y+V+E   ++   V+L+P TGRSHQLRVHM +LGHPILGD  Y    
Sbjct: 128 MVCHDTGKPALTDYQVLESDGES-TLVLLRPHTGRSHQLRVHMASLGHPILGDNLYG--- 183

Query: 186 ARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
            +    RLLLHA  L + HP  G   TF AP DF
Sbjct: 184 EQRPGERLLLHASQLGLYHPYSGEWTTFHAPCDF 217


>UniRef50_D1CBT6 Pseudouridine synthase n=1 Tax=Thermobaculum terrenum ATCC BAA-798
           RepID=D1CBT6_THET1
          Length = 313

 Score =  280 bits (719), Expect = 2e-74,   Method: Composition-based stats.
 Identities = 72/222 (32%), Positives = 103/222 (46%), Gaps = 11/222 (4%)

Query: 4   ENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP-------Q 56
           E    P    L ++Y+DD I+V++KP+G++  P         V   I R          +
Sbjct: 81  EVALIPSYVDLRVVYEDDKIIVIDKPAGMVVHPSPGHYDNTLVNALIARYPDLLKQPTDR 140

Query: 57  AESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLI 116
              VHRLD  TSG+I+VA        L+ Q + R+  K+Y     G   P EG ++ P+ 
Sbjct: 141 PGIVHRLDKDTSGLIIVARDLDTLNYLQGQMKARKIFKEYTLLCCGALDPPEGRIEAPIG 200

Query: 117 CDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPIL 176
            D  +R K  V    GK A TEY  ++         + +PITGR+HQ+RVH  A+GHPI 
Sbjct: 201 RDLRDRTKMSVI-AGGKEAVTEYSTIQSLG-KYTLAIARPITGRTHQIRVHFAAIGHPIA 258

Query: 177 GDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           GD  Y +        R  LHA  L +  P  G    + +P  
Sbjct: 259 GDPIYGN-CRLEGLNRQFLHASRLGVVMP-NGEYKEWHSPLP 298


>UniRef50_Q8K9E9 Ribosomal large subunit pseudouridine synthase D n=4 Tax=Buchnera
           aphidicola RepID=RLUD_BUCAP
          Length = 315

 Score =  280 bits (719), Expect = 2e-74,   Method: Composition-based stats.
 Identities = 63/231 (27%), Positives = 108/231 (46%), Gaps = 21/231 (9%)

Query: 6   YNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRD-----YPQAESV 60
            N PQ   L  +Y+D +I+++NKP GL+  PG   +    +   + R       P+   +
Sbjct: 76  INLPQNIALNTIYEDSNILIINKPPGLVVHPGAGNQDGTILNALLYRYTNISSIPRCGII 135

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLD  TSG++V+A T  +  +L    ++R+  ++Y   + G+     G+V+ P++    
Sbjct: 136 HRLDKDTSGLMVIAKTIFSYNKLVTLLKKRKIIRKYQGIIKGNMISG-GIVNYPIMRHPF 194

Query: 121 NRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRF 180
            R         GK + T Y+++     +   V  +  TGR+HQ+RVHML +G+P+LGD  
Sbjct: 195 KRICMTTDS-LGKKSITHYKIINRFKFH-THVSFRLETGRTHQIRVHMLHIGYPLLGDPL 252

Query: 181 YASPE-------------ARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           Y   +              +    R  LHA+ +   HP     M++ A   
Sbjct: 253 YGGIDYGCNYFQENRNIYRKFNLFRQALHADYIEFIHPFTQKVMSWSASLP 303


>UniRef50_C1CWT3 Pseudouridine synthase n=1 Tax=Deinococcus deserti VCD115
           RepID=C1CWT3_DEIDV
          Length = 321

 Score =  280 bits (718), Expect = 3e-74,   Method: Composition-based stats.
 Identities = 73/229 (31%), Positives = 104/229 (45%), Gaps = 19/229 (8%)

Query: 7   NPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRD------------Y 54
              ++  L ++Y+DD+++ VNKP G+++ P         V   + R              
Sbjct: 70  VEAEDLPLDVIYEDDYLIAVNKPPGMVTHPAPGVLSGTLVNALLGRMPLPEQPDYDSEAG 129

Query: 55  PQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPA-EGLVDL 113
            +   VHRLD  TSGVIVVA T  A   L   F++RE +K Y+A   G         V+ 
Sbjct: 130 YRPGIVHRLDKDTSGVIVVAKTVGAHARLAAAFKDRETRKTYLAIAAGQWRADGPARVEA 189

Query: 114 PLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADN----TARVVLKPITGRSHQLRVHML 169
           P+      R +  V     + AQT +  +    D      A V  +P TGR+HQ+RVH+ 
Sbjct: 190 PIGRHPVQRQRMTVGGANPREAQTLFTPLAAHPDGHGRTLALVRAQPRTGRTHQIRVHLA 249

Query: 170 ALGHPILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
            LG PILGD  Y       +  R  LHA  L++ HP  G  +   APA 
Sbjct: 250 HLGSPILGDAVYGRSSETML--RHALHAHFLSVPHPGTGRLLHLHAPAP 296


>UniRef50_B7HGW1 Pseudouridine synthase n=52 Tax=Bacillales RepID=B7HGW1_BACC4
          Length = 297

 Score =  280 bits (717), Expect = 3e-74,   Method: Composition-based stats.
 Identities = 63/214 (29%), Positives = 105/214 (49%), Gaps = 9/214 (4%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ-----AESVHRLD 64
           ++  L I+Y+DD ++++NK + + ++P R           +     Q        V RLD
Sbjct: 78  EDIPLCIIYEDDAVLIINKEANMSTIPSREHPAGSVANALLSHYDKQHLASTVHIVTRLD 137

Query: 65  MATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPK 124
             TSG++++A  +     L +Q +++  K+ Y A V G     EG++D P+     +  +
Sbjct: 138 RDTSGLMLIAKNRFVHHLLSKQHQQKAVKRTYEAIVHGKIVEREGMIDAPIGRKSDSIIE 197

Query: 125 QKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASP 184
           + VC E G+ A T ++V++        V L+  TGR+HQ+RVHM  +GHP+LGD  Y   
Sbjct: 198 RTVC-EDGQRAVTHFKVIDSTYHK-THVALELETGRTHQIRVHMAHVGHPLLGDSLYGGR 255

Query: 185 EARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
                  R  LH++ LT  HP     M+F     
Sbjct: 256 RDE--MKRQALHSKSLTFYHPILEKEMSFTIKLP 287


>UniRef50_B8FTI5 Pseudouridine synthase n=2 Tax=Desulfitobacterium hafniense
           RepID=B8FTI5_DESHD
          Length = 302

 Score =  280 bits (717), Expect = 3e-74,   Method: Composition-based stats.
 Identities = 64/221 (28%), Positives = 100/221 (45%), Gaps = 9/221 (4%)

Query: 3   MENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMT----RIQRDYPQA- 57
             N  P +   L ILY+DD+ + +NKP+G +  P                 + +   +  
Sbjct: 72  EINSIPGENLPLEILYEDDYFIAINKPAGQVVHPTPRYPRGTIGNAVVGYWLAKGEARPF 131

Query: 58  ESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLIC 117
             +HR+D  TSGV+V+   + A +++  Q       K Y   V G     +G +  P+  
Sbjct: 132 RPIHRIDRNTSGVVVIGKNQFAHQQMAWQHAHGRIHKCYRGIVEGQVMEDQGTIKAPIAL 191

Query: 118 DWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILG 177
              +  ++++    G PA T Y+V+E   D  + +     TGR+HQ+RVH   LGHP+LG
Sbjct: 192 APDSFIQRQI-SPEGSPAVTLYKVLERYQD-ASLLEFILETGRTHQIRVHCQHLGHPLLG 249

Query: 178 DRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           D  Y    AR    R  LH+ +    HP  G   T +AP  
Sbjct: 250 DDLYGGNLAR--INRQALHSSIYEFNHPLTGELTTIQAPLP 288


>UniRef50_O31613 Uncharacterized RNA pseudouridine synthase yjbO n=53
           Tax=Bacillaceae RepID=YJBO_BACSU
          Length = 283

 Score =  279 bits (716), Expect = 3e-74,   Method: Composition-based stats.
 Identities = 71/222 (31%), Positives = 102/222 (45%), Gaps = 9/222 (4%)

Query: 2   GMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDY-----PQ 56
            +      +   L ILY+D+H++V+NK   + S+P R           I           
Sbjct: 54  QVSETLLAEPVPLDILYEDEHVLVINKQPYVSSIPSREHPSGSIANGIIDHYQTTGVRAT 113

Query: 57  AESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLI 116
              V RLD  TSG+++VA  + A   L    +    K++Y A V G  +  EG VD P+ 
Sbjct: 114 VHLVTRLDRDTSGIMLVAKHRFAHSILSSAQKNGLVKRRYAAVVHGRMAQMEGTVDAPIG 173

Query: 117 CDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPIL 176
               +  ++ V    G+ A T + V   A D+   V L+  TGR+HQ+RVHM  LGHP+ 
Sbjct: 174 RHPDSIIERTV-TPDGQKAVTHFYV-TCANDDMTSVALQLETGRTHQIRVHMSYLGHPLC 231

Query: 177 GDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           GD  Y     R    R  LH+E L+  HP    +M F AP  
Sbjct: 232 GDTLYGG--TRQEIGRQALHSEHLSFIHPLTQENMRFHAPLP 271


>UniRef50_P59838 Ribosomal large subunit pseudouridine synthase D n=3
           Tax=Gammaproteobacteria RepID=RLUD_BLOFL
          Length = 321

 Score =  279 bits (716), Expect = 4e-74,   Method: Composition-based stats.
 Identities = 75/235 (31%), Positives = 111/235 (47%), Gaps = 22/235 (9%)

Query: 4   ENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDY------PQA 57
                PQ   L I+Y+D+ I+V+NK S ++  PG        +   + R         QA
Sbjct: 76  SEDIVPQNIPLNIIYEDNDILVINKASNMVVHPGIGHYQGTVLNALLYRYPSILKISKQA 135

Query: 58  ESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLIC 117
             V RLD  T+G++++A T +A   L R F+ R+  K+Y A V+G  +   G+V+ P+  
Sbjct: 136 GIVQRLDKDTTGLMIIAKTVSAYDNLLRSFKLRKVVKEYDAIVYGKFTSNAGVVNQPMRR 195

Query: 118 DWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILG 177
            +  R    V Y TGK A T Y VVE    + +RV +   TGR+HQ+RVHM  + HP++G
Sbjct: 196 HFAKRTFMSVHY-TGKSAVTYYSVVEEFKAH-SRVRINLKTGRTHQIRVHMAYINHPLVG 253

Query: 178 DRFYASPEARAMAP--------------RLLLHAEMLTITHPAYGNSMTFKAPAD 218
           D+ Y    +                   R  LHA  L + HP     M + AP  
Sbjct: 254 DQKYKGNFSVFDIKKMSDELNNYLLDFNRQALHACTLQLLHPITQVQMKWNAPLP 308


>UniRef50_D2RBY1 Pseudouridine synthase, RluA family n=1 Tax=Gardnerella vaginalis
           409-05 RepID=D2RBY1_GARVA
          Length = 321

 Score =  278 bits (713), Expect = 8e-74,   Method: Composition-based stats.
 Identities = 70/232 (30%), Positives = 110/232 (47%), Gaps = 18/232 (7%)

Query: 2   GMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRI----------Q 51
             E  N      + I+Y DD ++V++KP G+ S   +      +V   +           
Sbjct: 80  KEEQNNESSVCNIPIIYNDDDVVVIDKPVGVASHAAKG-WSGPTVPECLEAVGIDIKTTL 138

Query: 52  RDYPQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLV 111
            D  +   V RLD+ TSG+++V  T  A   +K QF +   KK Y A V G  +  +  +
Sbjct: 139 CDESRKGIVSRLDVGTSGLMLVCKTDFAYEVMKNQFAKHIVKKTYHALVQGDLAQDKATI 198

Query: 112 DLPLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLAL 171
           D P+     +  +  +    GKPA T ++V+E  +     V +   TGR+HQ+RVH  ++
Sbjct: 199 DAPIGRAKVSDFRFTI-TSDGKPAVTHWDVLERFSQ-ATLVSVNLETGRTHQIRVHFSSI 256

Query: 172 GHPILGDRFYASPE---ARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PAD 218
           GHP++GD  Y +      +    R  LH+  LT THP  G S+T K+  P D
Sbjct: 257 GHPLVGDSMYGANPVLAQKLGLQRQWLHSMELTFTHPRTGKSVTVKSHYPLD 308


>UniRef50_B7BE87 Pseudouridine synthase n=8 Tax=Bacteroidales RepID=B7BE87_9PORP
          Length = 551

 Score =  278 bits (712), Expect = 1e-73,   Method: Composition-based stats.
 Identities = 93/216 (43%), Positives = 122/216 (56%), Gaps = 19/216 (8%)

Query: 11  EPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ---AESVHRLDMAT 67
           +  L I+Y+D+ ++VVNKP+G+LSVPG+ +   DSV  R++R YP       VHRLDMAT
Sbjct: 334 DAELEIVYEDESLLVVNKPAGMLSVPGKSD--VDSVYQRVRRMYPGATGPMVVHRLDMAT 391

Query: 68  SGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKV 127
           SG+++VA TK   + L+ QF+ R   K+YVA + G     EG ++LPL  D  +RP+Q V
Sbjct: 392 SGLMLVAKTKEVHQNLQAQFKNRTVCKRYVAWLDGIVEEKEGHLELPLRPDPEDRPRQVV 451

Query: 128 CYETGKPAQTEYEVVEYAADNT------ARVVLKPITGRSHQLRVHMLA---LGHPILGD 178
               GKPA T+Y V+ Y             V   P TGR+HQLRVH      L  PI+GD
Sbjct: 452 DVVHGKPAVTDYRVLRYGGCKGGLRTTPTVVSFVPKTGRTHQLRVHSAHPLGLNAPIVGD 511

Query: 179 RFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFK 214
             Y        A RL LHAE L  THP  G  M  +
Sbjct: 512 ELYGKK-----ADRLYLHAEYLGFTHPVSGVYMEVE 542


>UniRef50_P59831 Ribosomal large subunit pseudouridine synthase A n=20
           Tax=Proteobacteria RepID=RLUA_HAEDU
          Length = 222

 Score =  277 bits (711), Expect = 1e-73,   Method: Composition-based stats.
 Identities = 135/222 (60%), Positives = 167/222 (75%), Gaps = 3/222 (1%)

Query: 1   MGMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESV 60
           M +  Y+PP  P+L  +Y+D+HI+V+NKPSGLLSVPG   E+ DSVMTR+Q+ Y  AE  
Sbjct: 1   MALIEYHPPLNPFLEEVYRDNHIVVINKPSGLLSVPGNRPEYYDSVMTRVQQRYGFAEPA 60

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPA---EGLVDLPLIC 117
           HRLDMATSG+I++AL+K AE+ELKRQFR+REPKK Y+A +WG         G ++ PLIC
Sbjct: 61  HRLDMATSGIILLALSKVAEKELKRQFRDREPKKHYIALLWGKLGDRVGQTGEINFPLIC 120

Query: 118 DWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILG 177
           DW NRP+QK+CYE GK A T YEV+E+ A+NT RV   PITGRSHQLRVH LALGHPI+G
Sbjct: 121 DWENRPRQKICYERGKKATTHYEVLEHLANNTTRVKFTPITGRSHQLRVHSLALGHPIIG 180

Query: 178 DRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
           D+FYA+P A+++APRL LHAE LTI HP     MTF     F
Sbjct: 181 DKFYANPLAKSLAPRLCLHAESLTIAHPISAELMTFNTEPTF 222


>UniRef50_Q28K21 Pseudouridine synthase n=11 Tax=Proteobacteria RepID=Q28K21_JANSC
          Length = 217

 Score =  277 bits (711), Expect = 1e-73,   Method: Composition-based stats.
 Identities = 116/219 (52%), Positives = 148/219 (67%), Gaps = 2/219 (0%)

Query: 1   MGMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESV 60
           M ++    P    L I+++D  +++VNKP+GLLSVPG+ E   D ++ R++  +P+   V
Sbjct: 1   MSVDFVYAPPTDPLDIIHEDHDLLLVNKPAGLLSVPGKGEHLSDCLIARLKIAFPEVLLV 60

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLDM TSGV+V A T  A+R L  QF +R  KK YVARVWG  +  +G +DLPLI DWP
Sbjct: 61  HRLDMDTSGVMVFARTPHAQRHLGLQFEKRHTKKAYVARVWGEVTDKDGHIDLPLIVDWP 120

Query: 121 NRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRF 180
           NRP Q V +ETGKPAQT++  +    D T R+ L P TGRSHQLRVHMLA+GHPILGD F
Sbjct: 121 NRPLQHVNHETGKPAQTDWRRI-RVEDGTTRMRLFPKTGRSHQLRVHMLAIGHPILGDPF 179

Query: 181 YASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
           YA+  A A  PRL+LHAE L + HP  G  MTF+A   F
Sbjct: 180 YATGPALA-FPRLMLHAESLKLRHPDGGIGMTFRARVPF 217


>UniRef50_C8NZX3 Pseudouridine synthase n=1 Tax=Erysipelothrix rhusiopathiae ATCC
           19414 RepID=C8NZX3_ERYRH
          Length = 298

 Score =  277 bits (710), Expect = 2e-73,   Method: Composition-based stats.
 Identities = 66/218 (30%), Positives = 100/218 (45%), Gaps = 8/218 (3%)

Query: 7   NPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR------DYPQAESV 60
             P +  + ++Y+D++++VVNKP GL+  PG   +    +   +         Y +   V
Sbjct: 70  IEPVKMDIDVVYEDEYLLVVNKPRGLVVHPGNGVKSDTLLHGLLYYLNSNCDHYIRPGLV 129

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HR+D  TSG++V+A      + L  Q  ++   + Y A V G    A  L+D P+  D  
Sbjct: 130 HRIDRNTSGLLVIAKDDKTHQFLAEQLLDKTMNRTYYALVHGVLPQAHVLIDAPIGPDKS 189

Query: 121 NRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRF 180
           N     V     KPA+T +E +E    N++ +  K  TGR+HQ+RVH L    P+ GD  
Sbjct: 190 NTKIMTVNQARSKPARTHFEKIETYI-NSSLICCKLETGRTHQIRVHALHANIPLHGDPQ 248

Query: 181 YASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           Y  P          L A  L   HP Y   M F+ P  
Sbjct: 249 YGHPSDTDK-TGQYLCAARLEFVHPKYLKLMQFEIPLP 285


>UniRef50_Q0VQA6 Pseudouridine synthase n=7 Tax=Gammaproteobacteria
           RepID=Q0VQA6_ALCBS
          Length = 229

 Score =  276 bits (708), Expect = 3e-73,   Method: Composition-based stats.
 Identities = 104/204 (50%), Positives = 133/204 (65%), Gaps = 1/204 (0%)

Query: 17  LYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDMATSGVIVVALT 76
           +Y+D+H++++NKP+ LLSVPGR  E+KD  + R+Q+ YP    VHRLD+ TSG++V  LT
Sbjct: 26  IYRDEHLLLINKPAYLLSVPGRAPENKDCAIRRLQQRYPDIRLVHRLDLDTSGIMVFGLT 85

Query: 77  KAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYETGKPAQ 136
             A+ +L R F+ R  KK+Y A V G      G +DLPLI DWP RP QKVC+ETGK A 
Sbjct: 86  AFAQSKLSRLFQLRTVKKRYQAIVHGLVEKNAGSIDLPLIADWPKRPLQKVCHETGKNAL 145

Query: 137 TEYEVVEYA-ADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARAMAPRLLL 195
           T Y V+E     N  R+ L P+TGRSHQLR+H   LGHPI+G   YA  E  A++PRLLL
Sbjct: 146 THYRVLERDIPGNRTRLALSPVTGRSHQLRIHCRELGHPIIGCDMYAPAEIEALSPRLLL 205

Query: 196 HAEMLTITHPAYGNSMTFKAPADF 219
           HAE L   HP  G    F +P  F
Sbjct: 206 HAEWLAFNHPLTGLWQEFTSPCPF 229


>UniRef50_A6TSZ4 Pseudouridine synthase n=1 Tax=Alkaliphilus metalliredigens QYMF
           RepID=A6TSZ4_ALKMQ
          Length = 308

 Score =  275 bits (706), Expect = 6e-73,   Method: Composition-based stats.
 Identities = 67/223 (30%), Positives = 110/223 (49%), Gaps = 10/223 (4%)

Query: 2   GMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP------ 55
              +   PQE    ++Y+D  ++V+NK  G++S P +    KD++    Q          
Sbjct: 74  EEASQFEPQEIPFNVVYEDIDVIVINKEPGIVSHPTKSHP-KDTIANAAQNYLEKKGVAC 132

Query: 56  QAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPL 115
           +   V+RLDM TSG++V+A        + +Q +  E  K+YVA V G     EG +D  +
Sbjct: 133 RIRFVNRLDMDTSGLLVIAKNPYTHHIMSQQMKANEITKKYVAFVKGVVVANEGEIDGAI 192

Query: 116 ICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPI 175
                   K+ V  + G+ + T++ V+E  AD    + +  +TGR+HQ+RVHM ++GHP+
Sbjct: 193 YRSSDETIKR-VVDDRGQQSLTKFTVLERYAD-ATMLEVSLLTGRTHQIRVHMESIGHPM 250

Query: 176 LGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           LGD  Y   +   +  R  LHA  L+   P Y   +  +A   
Sbjct: 251 LGDHLYGYVDTE-LIRRQALHASYLSFLQPRYKEKIEVRASLP 292


>UniRef50_Q8ERS8 Pseudouridine synthase n=2 Tax=Bacillaceae RepID=Q8ERS8_OCEIH
          Length = 322

 Score =  275 bits (705), Expect = 6e-73,   Method: Composition-based stats.
 Identities = 67/221 (30%), Positives = 107/221 (48%), Gaps = 10/221 (4%)

Query: 4   ENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ------A 57
            +   P++  L I+Y+D + +VVNKP+G   +P     H +++   +   Y +       
Sbjct: 93  SDAITPEKLPLDIIYEDAYCLVVNKPAGQACLPSMNHRH-NTLANGLTYYYQKNSIPSTV 151

Query: 58  ESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLIC 117
             V RLD+ TSG+++VA  +       R  +E    + Y A V G  SP  G+VD P+  
Sbjct: 152 HIVTRLDVNTSGLVLVAKNQYVHSLFSRMQQEGNINRVYEAIVHGEVSPTSGIVDAPIAR 211

Query: 118 DWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILG 177
              +  ++ V    GK A+T Y V+ YA    + V +K  TGR+HQ+RVH   LGH + G
Sbjct: 212 KEGSIIERTVDMRNGKYAKTNYRVL-YADSIASWVEIKLETGRTHQIRVHFQYLGHSLYG 270

Query: 178 DRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           D  Y   +   +  R  LH + +T+ HP     +  +A   
Sbjct: 271 DNLYGGSKDIML--RQALHCKQITMMHPIKNQPIQLEASLP 309


>UniRef50_C0EHV8 Putative uncharacterized protein n=1 Tax=Clostridium methylpentosum
           DSM 5476 RepID=C0EHV8_9CLOT
          Length = 299

 Score =  275 bits (704), Expect = 9e-73,   Method: Composition-based stats.
 Identities = 68/221 (30%), Positives = 102/221 (46%), Gaps = 10/221 (4%)

Query: 4   ENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ------A 57
                P      I Y+DD +++VNKP+G    P     ++DS+       Y Q       
Sbjct: 70  SQSIRPVPGPFDIAYEDDDLLLVNKPAGTPVHPSPGH-YEDSLANYSAWQYAQRREQLVF 128

Query: 58  ESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLIC 117
             V+RLD  TSG++ VA    A+  L +Q      ++ Y A V G PSPA G +DLP+  
Sbjct: 129 RPVNRLDRGTSGLLCVAKNAHAQARLSQQLHTGAFERIYYAVVCGAPSPAAGTIDLPIGR 188

Query: 118 DWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILG 177
              +  K++V  +  + A T YE V         + ++  TGR+HQ+RVH   LG P+ G
Sbjct: 189 TPGSVLKRRVDPQGAR-AVTHYETV-RVNGAYTLLKIRLETGRTHQIRVHFAHLGCPLFG 246

Query: 178 DRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           D  Y + E R +     LH+  + + HP  G  +    P  
Sbjct: 247 DFLYGT-ERRDVVEGHALHSGEIRLLHPISGEEIRCSVPLP 286


>UniRef50_Q3ECD0 RNA pseudourine synthase 2, chloroplastic n=4 Tax=Magnoliophyta
           RepID=PUS2_ARATH
          Length = 430

 Score =  274 bits (703), Expect = 1e-72,   Method: Composition-based stats.
 Identities = 70/274 (25%), Positives = 111/274 (40%), Gaps = 63/274 (22%)

Query: 8   PPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR------DYP------ 55
             ++  L I+Y+D H++VVNKP+ ++  P         V   +        DY       
Sbjct: 142 EAEDIPLDIVYEDKHVLVVNKPAHMVVHPAPGNPTGTLVNGILHHCSLPCVDYSNSEEDD 201

Query: 56  ------------------------QAESVHRLDMATSGVIVVALTKAAERELKRQFRERE 91
                                   +   VHRLD  T+G++VVA  + +   L  QF+   
Sbjct: 202 DSDEETFSDDEEMTTSPSSYAASVRPGIVHRLDKGTTGLLVVAKDEHSHAHLAEQFKLHT 261

Query: 92  PKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQK-----VCYETGKPAQTEYEVVEYA- 145
            ++ YV+   G PSP +G +++P+  D  NR +       V     + A + Y+V+E   
Sbjct: 262 IERVYVSLTTGVPSPPQGRIEIPIGRDSSNRIRMAAIPGGVRGGRARHAASRYKVIETFA 321

Query: 146 ADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARAM---------------- 189
              +A V  +  TGR+HQ+R H   +G P+LGD  Y   ++ A+                
Sbjct: 322 GGGSALVEWRLETGRTHQIRAHAKYMGVPLLGDEVYGGTKSMALSLLQKRVSRSDQEEII 381

Query: 190 -----APRLLLHAEMLTITHPAYGNSMTFKAPAD 218
                  R  LHA +L  THP  G  + F  P  
Sbjct: 382 ELISRMDRPCLHAIVLGFTHPCTGEIVKFSCPPP 415


>UniRef50_B4U613 Pseudouridine synthase, RluA family n=1 Tax=Hydrogenobaculum sp.
           Y04AAS1 RepID=B4U613_HYDS0
          Length = 308

 Score =  274 bits (703), Expect = 1e-72,   Method: Composition-based stats.
 Identities = 70/224 (31%), Positives = 105/224 (46%), Gaps = 17/224 (7%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYPQAESVH 61
           Q+  + ILY+D+ + VV KPSG+ S  G   +    V   + +           +   VH
Sbjct: 75  QDIHIDILYEDNDLAVVVKPSGMPSHTGPGHDENTLVNALLAKFGDLSVIGGVERPGIVH 134

Query: 62  RLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPN 121
           RLD  T G++V+A    + ++L   F+ +E  K Y A V+G     E  ++  +     N
Sbjct: 135 RLDRYTHGLMVIAKNDVSHQKLSLMFKNKEVDKHYKAIVYGISRFKEQTIETFIRRHPTN 194

Query: 122 RPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFY 181
           R K +V  E GK A T+Y  +E    N + + +K  TGR+HQ+RVHM  +GHPI+GD  Y
Sbjct: 195 RLKFEVANE-GKLAITKYS-LEKPLKNASLLDIKIYTGRTHQIRVHMSYIGHPIVGDTLY 252

Query: 182 ASPE-------ARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
                         +  R LL A  L+  HP     M F+    
Sbjct: 253 GYKHSYFDKTLEHMIGKRFLLVAYKLSFLHPKSQKPMEFEIDMP 296


>UniRef50_C7MN62 Pseudouridine synthase n=8 Tax=Coriobacteriaceae RepID=C7MN62_CRYCD
          Length = 347

 Score =  274 bits (702), Expect = 1e-72,   Method: Composition-based stats.
 Identities = 56/220 (25%), Positives = 97/220 (44%), Gaps = 18/220 (8%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP----------QAES 59
           +   L + ++D  +M ++K +GL   P    E    V   I               +   
Sbjct: 78  EPIPLDVRFEDRWMMAISKQAGLCVHPAPGHEGGTLVNALIYAYGRDSLAHVQGDDRPGI 137

Query: 60  VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDW 119
           VHRLDM TSG+++ A        L+   R+ +  ++Y+  V G+ +   G +D P+    
Sbjct: 138 VHRLDMDTSGLMMCAKDDTCGMALQDLVRDHKVDRRYLTLVHGNIAFDTGQIDEPIGRVG 197

Query: 120 PNRPKQKVC-YETGKPAQTEYEVVEYAA-----DNTARVVLKPITGRSHQLRVHMLALGH 173
            +R + K+    T + A T + V+E        +    +  +  TGR+HQ+RVHM  +GH
Sbjct: 198 DDRLRMKISYRPTARNALTTFTVLERFEAGRADNGYTLLECRLYTGRTHQIRVHMEFIGH 257

Query: 174 PILGDRFY--ASPEARAMAPRLLLHAEMLTITHPAYGNSM 211
             +GD  Y   + +      R  LH+  L+  HP  G+ +
Sbjct: 258 CCVGDPLYRWGNEQVNLELSRQFLHSYSLSFNHPMTGDDI 297


>UniRef50_C0MA80 Pseudouridine synthase n=6 Tax=Streptococcus RepID=C0MA80_STRE4
          Length = 300

 Score =  274 bits (702), Expect = 1e-72,   Method: Composition-based stats.
 Identities = 65/206 (31%), Positives = 101/206 (49%), Gaps = 12/206 (5%)

Query: 13  WLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDY-------PQAESVHRLDM 65
            L I+Y+D+H +++NKP+G  S+P  +    +++   I+  Y        Q   V RLD 
Sbjct: 75  DLDIVYEDEHFLILNKPAGYASIPSAIHS--NTIANFIKAYYIKQDYPNKQVHIVTRLDR 132

Query: 66  ATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPS-PAEGLVDLPLICDWPNRPK 124
            TSG+++ A    A   L +Q ++R   K+Y A V G    P +G +  P+     +   
Sbjct: 133 DTSGLMLFAKHGYAHARLDKQLQQRAINKRYYALVCGQERLPDQGEIIAPIGRTDDSIIT 192

Query: 125 QKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASP 184
           + V    GK A+T Y+V+    +N + V +   TGR+HQ+RVH   LG P+LGD  Y   
Sbjct: 193 RTV-TPKGKYAKTSYKVIARYPENVSLVDITLHTGRTHQIRVHFAHLGFPLLGDDLYGGR 251

Query: 185 EARAMAPRLLLHAEMLTITHPAYGNS 210
                  R  LH   L+ THP   + 
Sbjct: 252 LD-LGMTRQALHCHHLSFTHPFTESR 276


>UniRef50_A4J479 Pseudouridine synthase n=1 Tax=Desulfotomaculum reducens MI-1
           RepID=A4J479_DESRM
          Length = 303

 Score =  274 bits (702), Expect = 2e-72,   Method: Composition-based stats.
 Identities = 64/220 (29%), Positives = 109/220 (49%), Gaps = 11/220 (5%)

Query: 2   GMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP------ 55
             E    P+   L ILY+D H++ VNKP G+L  P    E   ++   +   +       
Sbjct: 72  SQETQVVPERMELNILYEDAHLLAVNKPPGMLVHP-LTNETSGTLANGVLYHWLQQGTID 130

Query: 56  QAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPL 115
           +   VHRLD  TSG++++A     +++L+ Q ++ +  ++Y+A V G   P +G++  P+
Sbjct: 131 RFRPVHRLDRNTSGIVLIARNPYVQQQLQIQMKQGQFVRRYLALVKGKVQPEQGVIQAPI 190

Query: 116 ICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPI 175
             +  +  K+ +    GK A + Y+V+       + V ++  TGR+HQ+RVHM  +GHP+
Sbjct: 191 ALEEGSFIKRMI-SPAGKEAISHYQVLRTFNQ-ASLVRVELETGRTHQVRVHMAHMGHPL 248

Query: 176 LGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKA 215
           LGD  Y    +     R  LH   L   HP  G+ +    
Sbjct: 249 LGDSLYGGDTSN--IKRQALHCAYLAFNHPVQGSRIKISC 286


>UniRef50_Q5Z8P2 RNA pseudourine synthase 2, chloroplastic n=6 Tax=Magnoliophyta
           RepID=PUS2_ORYSJ
          Length = 445

 Score =  273 bits (700), Expect = 3e-72,   Method: Composition-based stats.
 Identities = 69/282 (24%), Positives = 111/282 (39%), Gaps = 71/282 (25%)

Query: 8   PPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------------- 52
            P++  L I+Y+DDH++VVNKP+ ++  P     +   V   +                 
Sbjct: 134 EPEDIPLDIVYEDDHLLVVNKPAHMVVHPAPGNANGTLVNAILHHCKISTFTCLARNSID 193

Query: 53  ------------------------------DYPQAESVHRLDMATSGVIVVALTKAAERE 82
                                            +   VHRLD  TSG++VVA  + +  +
Sbjct: 194 DECPDSSDDDIDVFDIDQFTTGEVSSEVREALVRPGIVHRLDKGTSGLLVVAKDEHSHAQ 253

Query: 83  LKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYETG----KPAQTE 138
           L  QF+    ++ Y++   G P+P  G +++P+  D  NR +      +G    + A + 
Sbjct: 254 LAEQFKLHTIRRVYISLTCGAPNPNSGRIEVPIARDPNNRIRMIATPGSGHRYARHAASR 313

Query: 139 YEVVEYA-ADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARAM-------- 189
           Y+V E      +A V  +  TGR+HQ+R H   LG P+LGD  Y   ++ A+        
Sbjct: 314 YKVREVFAGGGSALVEWRLETGRTHQIRAHAKYLGIPLLGDETYGGTKSMALSLLRPRTP 373

Query: 190 -------------APRLLLHAEMLTITHPAYGNSMTFKAPAD 218
                          R  LHA +L   HP  G  + F  P  
Sbjct: 374 SRYHCDLSNMISKIDRPCLHAALLGFKHPHSGKILEFSCPPP 415


>UniRef50_C2D7A7 Pseudouridine synthase n=1 Tax=Atopobium vaginae DSM 15829
           RepID=C2D7A7_9ACTN
          Length = 338

 Score =  273 bits (700), Expect = 3e-72,   Method: Composition-based stats.
 Identities = 57/231 (24%), Positives = 96/231 (41%), Gaps = 18/231 (7%)

Query: 6   YNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR----------DYP 55
             P     L I Y+DD+++V++K +GL+  P             +               
Sbjct: 78  IMPNASIPLDIRYEDDYLLVISKQTGLVCHPSPGHVDDTLSNALVAHCGYEHLGLLQGDD 137

Query: 56  QAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPL 115
           +   VHRLDM T+G++V A     ++ L+   R R   ++Y+  V G+ +P EG +   +
Sbjct: 138 RPGIVHRLDMDTTGLMVAAKDNTTQQALQDLIRLRVFDRRYIVLVQGYVTPDEGTITTGI 197

Query: 116 ICDWPNRPKQKVC-YETGKPAQTEYEVVEYAA-----DNTARVVLKPITGRSHQLRVHML 169
                NR K  +      + A T ++ +E        D  + +     TGR+HQ+RVHM 
Sbjct: 198 ARSKKNRLKMCISKDPASREAITTFKTLERFEAGSKDDGYSLLECHLYTGRTHQIRVHMR 257

Query: 170 ALGHPILGDRFYA--SPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
            +GH ++GD  Y            R  LH+  ++  HP     + F     
Sbjct: 258 YVGHSVVGDPLYGRKGDALNQGLQRQFLHSWRMSFDHPITHEHLQFCDKLP 308


>UniRef50_D2M2K8 Pseudouridine synthase, RluA family n=1 Tax=Bacillus
           cellulosilyticus DSM 2522 RepID=D2M2K8_BACS4
          Length = 298

 Score =  273 bits (699), Expect = 3e-72,   Method: Composition-based stats.
 Identities = 71/219 (32%), Positives = 107/219 (48%), Gaps = 11/219 (5%)

Query: 6   YNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAES------ 59
              P +  L I+++D+H++++NKP  L ++P R  E + S+   I   Y +         
Sbjct: 75  SIKPYKIKLHIIFEDEHVIIINKPPHLPTIPTR-NEGEPSLAGAILAYYIENGIPSTFHA 133

Query: 60  VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDW 119
           V RLD  TSG+++VA  +       +  +  E K+ YVA V G  S     +DLP+    
Sbjct: 134 VSRLDRDTSGLVMVAKHRYMHDLCVKLQKSYEIKRSYVALVEGILSDDYNTIDLPISRKT 193

Query: 120 PNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDR 179
            +  +++V  E GK A T YEV++        + L   TGR+HQ+RVHM A+GHP+LGD 
Sbjct: 194 TSIIEREV-NEFGKSAITHYEVLKRY-SGATLLQLTLETGRTHQIRVHMSAIGHPLLGDT 251

Query: 180 FYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
            Y          R  LH+  L+  HP      TF  P  
Sbjct: 252 LYGGD--VRYIDRQALHSHQLSFFHPINKREYTFHCPIP 288


>UniRef50_A3DDK9 Pseudouridine synthase, RluA family n=3 Tax=Clostridium
           thermocellum RepID=A3DDK9_CLOTH
          Length = 318

 Score =  273 bits (699), Expect = 4e-72,   Method: Composition-based stats.
 Identities = 58/239 (24%), Positives = 97/239 (40%), Gaps = 29/239 (12%)

Query: 6   YNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVH---- 61
           +  P++  + I+Y+D+ ++ +NK  G++  P         +   +     +   V     
Sbjct: 71  FIQPEDIPIDIIYEDEFLIALNKQPGIVVHPTCSHPGGT-LANAVAFHLQKKGIVKKIRP 129

Query: 62  --RLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDW 119
             RLD  TSG+I+ A     +  L RQ  ++   K+Y+  V        G +DLP+    
Sbjct: 130 VIRLDRDTSGIIIFAKNPYCQEFLIRQMNDKTFIKEYIGIVHKVLENDNGTIDLPIARKP 189

Query: 120 PNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDR 179
            +   + +    G PA T Y V+E   +    V  +  TGR+HQ+RVH  A+GHP+LGD 
Sbjct: 190 GSIMLRHI-SPDGDPAVTHYTVLERL-NGATLVKFRLETGRTHQIRVHCQAIGHPLLGDT 247

Query: 180 FY----------ASPEA----------RAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
            Y           +               +  R  LH++     HP     +   AP  
Sbjct: 248 LYPFEDTPYSLSGNNPHITQANTPSITSGIITRQALHSQRAVFLHPFTKKILEITAPIP 306


>UniRef50_C5RBB6 23S rRNA pseudouridylate synthase RluD n=1 Tax=Weissella
           paramesenteroides ATCC 33313 RepID=C5RBB6_WEIPA
          Length = 305

 Score =  273 bits (699), Expect = 4e-72,   Method: Composition-based stats.
 Identities = 66/216 (30%), Positives = 107/216 (49%), Gaps = 11/216 (5%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ-------AESVHR 62
            +  + ILY+D++ +VV+K +G+ SVPG+ +  + +++ R++               V R
Sbjct: 75  SDLPIKILYEDENWLVVDKVAGVTSVPGKADR-ETTMVNRVKGYLISEGAEDLVPHVVTR 133

Query: 63  LDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNR 122
           LD  TSGV ++A  + A   L +Q +     K+Y A V G      G +D P+     + 
Sbjct: 134 LDRFTSGVALLAKHRFAHGLLDKQLQTHTVDKRYYAIVDGIVPDDHGFIDAPIGRMDNDF 193

Query: 123 PKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYA 182
            +++V    G+P+QTEY VV    +    V ++  TGR+HQ+RVH   +GHP++GD  Y 
Sbjct: 194 IRREV-RADGRPSQTEYWVVNRMPNQ-TLVKVQLHTGRTHQIRVHFKYIGHPLIGDEIYG 251

Query: 183 SPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
            P  R    R  LHA  L    P        ++P  
Sbjct: 252 GPMDR-GIERQALHAYWLEFYDPFSEIKRHIQSPLP 286


>UniRef50_A8RHQ2 Pseudouridine synthase n=2 Tax=Clostridium RepID=A8RHQ2_9CLOT
          Length = 287

 Score =  273 bits (699), Expect = 4e-72,   Method: Composition-based stats.
 Identities = 68/227 (29%), Positives = 112/227 (49%), Gaps = 13/227 (5%)

Query: 2   GMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAE--- 58
                  P +  L I+Y+D+ I+V+NK +G+   P +     +++   +   + +     
Sbjct: 57  EDSGNIVPVKLPLSIVYEDEDILVINKDAGVPIHPSQGHYD-NTLANAVSWYFHEKGEAF 115

Query: 59  ---SVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPL 115
               ++RLD  T+G++V+A    +   L  Q   R  +++Y A V GH +P EG VD P+
Sbjct: 116 TYRVINRLDRDTTGLLVLARHMLSACILSEQMTGRRIRREYRAIVLGH-TPEEGTVDSPI 174

Query: 116 ICDWPNRPKQKVCYETGKPAQTEYEVVEYAADN-TARVVLKPITGRSHQLRVHMLALGHP 174
                +  +++V +ETG+ A T +  + Y  +   + V L   TGR+HQ+RVHM ++GHP
Sbjct: 175 ARAEGSTIERRVDHETGERAVTHFRTLLYNEEKDLSLVSLSLETGRTHQIRVHMRSIGHP 234

Query: 175 ILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
           + GD  Y          R  LH+ +L   HP  G  M F A  P D 
Sbjct: 235 LPGDFLYCPD--YRYIDRQPLHSYLLRFEHPITGKEMEFTAGLPEDM 279


>UniRef50_B8I750 Pseudouridine synthase, RluA family n=2 Tax=Clostridium
           RepID=B8I750_CLOCE
          Length = 299

 Score =  272 bits (698), Expect = 5e-72,   Method: Composition-based stats.
 Identities = 64/224 (28%), Positives = 105/224 (46%), Gaps = 10/224 (4%)

Query: 2   GMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP------ 55
               +  PQ+  L ++Y+D+ ++V+NK SG++  P       +++   I           
Sbjct: 67  EECEHIEPQDIPLDVIYEDECMLVLNKQSGIVVHPTSYHPD-NTIANGIVYYLKQKGVTK 125

Query: 56  QAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPL 115
           +   V RLD  TSG+I+ A  +  +  L +Q      KK+Y+  V G P   EG ++LP+
Sbjct: 126 KVRPVSRLDRETSGIIIFAKNQFTQEMLIQQMHNNLFKKEYLGIVQGIPQNNEGTINLPI 185

Query: 116 ICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTA-RVVLKPITGRSHQLRVHMLALGHP 174
                +   + +  E G P+ T Y++++    + +  +  K  TGR+HQ+RVH  A+G P
Sbjct: 186 ARKPGSIMLRHI-SEEGAPSITHYKILKTFPSHNSALLSFKLETGRTHQIRVHCKAMGFP 244

Query: 175 ILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           I GD  Y S        R  LH+    I HP     + FKA   
Sbjct: 245 IYGDTLY-SDNTNLFISRQALHSYRTEIIHPVTLKGVIFKAELP 287


>UniRef50_C0Z877 Pseudouridine synthase n=1 Tax=Brevibacillus brevis NBRC 100599
           RepID=C0Z877_BREBN
          Length = 310

 Score =  272 bits (698), Expect = 5e-72,   Method: Composition-based stats.
 Identities = 70/216 (32%), Positives = 106/216 (49%), Gaps = 9/216 (4%)

Query: 8   PPQEPW-LVILYQDDHIMVVNKPSGLLSVP----GRLEEHKDSVMTRIQRDYPQAESVHR 62
           P      + ILY+DDH+++ NKP+G++  P         H  + +   + +      VHR
Sbjct: 87  PNTPMPSIDILYEDDHLLIANKPAGMMVHPIKQETDTLVHALAAVLAARGEQTSVHPVHR 146

Query: 63  LDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNR 122
           LD  TSG I+VA +    +   R  RE    ++Y+A   G  S   G +D P+  D  + 
Sbjct: 147 LDKDTSGAILVAKSSYGHQLADRLLREGGIHREYLAVASGVLSEGAGTIDAPIGRDARHP 206

Query: 123 PKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYA 182
            K++V  E+G PA T YEV +  ++      +   TGR+HQ+RVH   +GHP+ GD  Y 
Sbjct: 207 TKRRVV-ESGDPAITHYEV-QQTSEEMTLARVWLETGRTHQIRVHFAHIGHPLAGDTMYG 264

Query: 183 SPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
              AR +  R  LHA  L+  HP     +  +AP  
Sbjct: 265 G--ARGLLRRQALHASKLSFLHPLLEKEIVVEAPIP 298


>UniRef50_C2L1H2 Pseudouridine synthase n=1 Tax=Oribacterium sinus F0268
           RepID=C2L1H2_9FIRM
          Length = 335

 Score =  272 bits (697), Expect = 6e-72,   Method: Composition-based stats.
 Identities = 63/251 (25%), Positives = 108/251 (43%), Gaps = 33/251 (13%)

Query: 1   MGMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ---- 56
           M  EN  PP +  L I+Y+D  I++++KP+ L   P      K      +          
Sbjct: 77  MEEENSAPPYDFPLDIVYEDRDILLLDKPARLPCHPSPGHFEKTLAGAIVFYQMQNSSAS 136

Query: 57  ---AESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLV-- 111
                 +HRLD+ TSG+I++A  + A   L +  +E   ++ Y+A   G+P  + G +  
Sbjct: 137 SFVCHFIHRLDLDTSGLILLAKNRLAASVLNKDMKEGRIQRSYLAFCQGNPEFSLGEIQG 196

Query: 112 ------------------DLPLICDWPNRPKQKVCYETGKPAQTEYEVVEYAAD-NTARV 152
                               P+      +  + V ++ G+ A + + V+ Y  + N + +
Sbjct: 197 FTRLEEKKKKEFNYAFAISAPIARVEEEKMLRTVNFQKGQEALSYFNVLNYFPEKNYSLL 256

Query: 153 VLKPITGRSHQLRVHMLALGHPILGDRFYASPEA-----RAMAPRLLLHAEMLTITHPAY 207
            L+  TGR+HQ+RVH+  L  P+LGD  Y + E           R  LH+  ++ THP  
Sbjct: 257 QLQLATGRTHQIRVHLSYLSCPLLGDSLYGNGEESVFSQNIGLSRQALHSYSISFTHPIR 316

Query: 208 GNSMTFKAPAD 218
              M F+    
Sbjct: 317 KEKMFFQRELP 327


>UniRef50_Q1WS43 Pseudouridine synthase n=3 Tax=Lactobacillus RepID=Q1WS43_LACS1
          Length = 296

 Score =  272 bits (697), Expect = 6e-72,   Method: Composition-based stats.
 Identities = 68/213 (31%), Positives = 101/213 (47%), Gaps = 11/213 (5%)

Query: 13  WLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ-------AESVHRLDM 65
            L I+Y+D + +VV+KP  L SVPG      D+++ R++    Q          + RLD 
Sbjct: 76  PLDIIYEDSNWLVVDKPPLLSSVPGPSNRT-DTLVNRVKFHLWQQKSKDLVPHVITRLDR 134

Query: 66  ATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQ 125
            TSG+++VA  + A+  + +Q  E    K+Y+A V G  +   G++D PL        + 
Sbjct: 135 DTSGLVLVAKHRFAQGLINKQVEEHSIDKKYLAVVEGIITEKHGIIDKPLGPRENGIGQM 194

Query: 126 KVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPE 185
               +TGK A+TEY V EY  D    V  K  TGR+HQ+R H  ++ H ++GD  Y    
Sbjct: 195 --VTDTGKIAKTEYWVREYLGDKATLVECKLHTGRTHQIRAHFSSINHALVGDELYGGRL 252

Query: 186 ARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
                 R  LHA  L    P       FK+   
Sbjct: 253 D-WGLERQALHAYQLAYVDPFTQEEKLFKSEMP 284


>UniRef50_B8DF66 Pseudouridine synthase n=18 Tax=Listeria RepID=B8DF66_LISMH
          Length = 289

 Score =  272 bits (696), Expect = 8e-72,   Method: Composition-based stats.
 Identities = 74/220 (33%), Positives = 112/220 (50%), Gaps = 12/220 (5%)

Query: 5   NYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAE------ 58
           +  P  E  L I+Y+DD ++VVNKP  + +      E  D+    +Q    +        
Sbjct: 69  DKIPTYEYDLEIIYEDDFLLVVNKPVDMKTHANDSYET-DTCANAVQYYLEKTGQDANAL 127

Query: 59  SVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICD 118
           +VHRLD  TSG+++ A  K A   L  Q   R   + Y+A V G        ++ P+  D
Sbjct: 128 AVHRLDQTTSGLVLFAKNKLAIAGLSWQMENRAIHRTYLAAVDGTWGLVMQTINKPIGED 187

Query: 119 WPNRPKQKVCYETGKPAQTEYEVVEYAAD-NTARVVLKPITGRSHQLRVHMLALGHPILG 177
             +  ++++    G+PA T  +V+E   + NT+ V  +  TGR+HQ+RVH+  +GHPI+G
Sbjct: 188 RHHGSRRQI-SPYGQPAVTHVKVLENDNEKNTSLVECQIETGRTHQIRVHLSGIGHPIIG 246

Query: 178 DRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPA 217
           D  Y        A R++LHAE L + HP  G  M F APA
Sbjct: 247 DTLYGGS---PRANRIMLHAEKLHLNHPFKGKEMNFSAPA 283


>UniRef50_A4J9H9 Pseudouridine synthase n=2 Tax=Clostridiales RepID=A4J9H9_DESRM
          Length = 320

 Score =  272 bits (696), Expect = 9e-72,   Method: Composition-based stats.
 Identities = 63/225 (28%), Positives = 108/225 (48%), Gaps = 12/225 (5%)

Query: 1   MGMENY-NPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ--- 56
           +   NY   P++  + +LY+DD ++V+NKP+  L  P   +  + ++   +     Q   
Sbjct: 88  LEDTNYGVQPEKGAIEVLYEDDFLLVLNKPAHQLVHPT-GQTTRGTMANYLAYYLKQRNV 146

Query: 57  ---AESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDL 113
                 VHRLD  TSG ++ A    ++  L++Q +ER  K+ Y A V G   P  G +D 
Sbjct: 147 VSAIRPVHRLDRETSGCVIFAKDSRSQFILEQQLKERTLKRTYWALVKGIVHPPSGTIDA 206

Query: 114 PLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGH 173
           P+        ++ +  E G+ + T Y+ +    +  + + L   TGR+HQ+R+H+  LG+
Sbjct: 207 PIGPHPSLANRRAI-NEHGEQSITHYQTLRSFPE-ISLLKLNLDTGRTHQIRLHLAHLGY 264

Query: 174 PILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           PI+GDR Y          R  LHA  ++  H    + +   AP  
Sbjct: 265 PIIGDRMYGVRS--PWINRQALHAYDVSFRHLKENHEIAVHAPLP 307


>UniRef50_A5ZUU7 Pseudouridine synthase n=1 Tax=Ruminococcus obeum ATCC 29174
           RepID=A5ZUU7_9FIRM
          Length = 293

 Score =  271 bits (695), Expect = 1e-71,   Method: Composition-based stats.
 Identities = 60/220 (27%), Positives = 102/220 (46%), Gaps = 11/220 (5%)

Query: 5   NYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ------AE 58
           +   P    + +LY+D+ I+VVNKP+ +   P       +++   +              
Sbjct: 72  DGILPTPLNIPVLYEDEDILVVNKPADMPVHPSLGNYT-NTLANGVAAYLETKGESCPFR 130

Query: 59  SVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICD 118
            ++RLD  TSG +++A    +   L  Q R R+  + Y+A V G P    G +  P+   
Sbjct: 131 CINRLDRDTSGALILAKNALSAAILSVQMRNRQISRTYLAVVEGIPRQ-SGTISAPISRA 189

Query: 119 WPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGD 178
             +  ++++ +E G+ A T Y+++E   +N + + +   TGR+HQ+RVHM  +GHP+  D
Sbjct: 190 ADSVIERRIDFENGESAITHYQLLE-VKNNHSLLEIHLETGRTHQIRVHMGYIGHPLPAD 248

Query: 179 RFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
             Y          R  LH+  L   HP  G  M   AP  
Sbjct: 249 YLYNP--VYDTFKRQPLHSLQLKFCHPITGTPMCLMAPVP 286


>UniRef50_B1XXM0 Pseudouridine synthase n=6 Tax=Burkholderiales RepID=B1XXM0_LEPCP
          Length = 369

 Score =  271 bits (694), Expect = 1e-71,   Method: Composition-based stats.
 Identities = 66/226 (29%), Positives = 107/226 (47%), Gaps = 23/226 (10%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDY-----PQAESVHRLD 64
           +   L ++++D H++V++KP+GL+  P         +   +         P+A  VHRLD
Sbjct: 115 EAMTLAVVHEDAHLLVIDKPAGLVVHPAAGHWSGTLLNGLLAHHAAAAHLPRAGIVHRLD 174

Query: 65  MATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPK 124
             TSG+++VA +  A   L R    R+ K++Y+A V G       ++D PL  D  +R +
Sbjct: 175 KDTSGLMLVAKSLQAHTALVRAIAARDVKREYLALVHGAVMDGLQVIDAPLGRDPVSRVR 234

Query: 125 QKVCYETGKPAQTEYEVVE----------------YAADNTARVVLKPITGRSHQLRVHM 168
             +   +GKPA+T+   +                  A    + V  +  TGR+HQ+RVH+
Sbjct: 235 MAIV-ASGKPARTDVRRLAVAELPGDGVRQLPGATRAPRQVSAVHCQLHTGRTHQIRVHL 293

Query: 169 LALGHPILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFK 214
            + GHP+L D  Y    A     R  LHA  L + HP  G  + F+
Sbjct: 294 ASRGHPLLADAMYGGAPA-FGLQRQALHAARLHLLHPIDGRPLAFE 338


>UniRef50_B6TXP4 RNA binding protein n=3 Tax=Poaceae RepID=B6TXP4_MAIZE
          Length = 439

 Score =  270 bits (693), Expect = 2e-71,   Method: Composition-based stats.
 Identities = 66/282 (23%), Positives = 105/282 (37%), Gaps = 71/282 (25%)

Query: 8   PPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------------- 52
             ++  L I+Y+DDH++VVNKP+ ++  P         V   +                 
Sbjct: 132 EAEDIPLDIVYEDDHVLVVNKPAHMVVHPAPGNAKGTLVNAILHHCKISTFTCLARSSAG 191

Query: 53  ------------------------------DYPQAESVHRLDMATSGVIVVALTKAAERE 82
                                            +   VHRLD  TSG++VVA  + +   
Sbjct: 192 DECPDSSDEDTDVFHVDQFAAEDVSSEVRNALVRPGIVHRLDKGTSGLLVVAKDEHSHAR 251

Query: 83  LKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYETG----KPAQTE 138
           L  QF+    ++ Y++   G P+P  G ++  +  D  NR +      +G    + A + 
Sbjct: 252 LAEQFKLHTIRRVYISLTCGAPNPNSGRIEASIARDPNNRIRMTAIAGSGHRYARNAASR 311

Query: 139 YEVVEYA-ADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARAM-------- 189
           Y+V E      +A V  +  TGR+HQ+R H   +G P+LGD  Y   ++ A+        
Sbjct: 312 YKVREVFAGGGSALVEWRLETGRTHQIRAHAKYIGIPLLGDETYGGTQSMALSLLRPRSP 371

Query: 190 -------------APRLLLHAEMLTITHPAYGNSMTFKAPAD 218
                          R  LHA  L   HP  G  + F  P  
Sbjct: 372 SKYHSGLSNLLSKVDRPCLHAASLGFKHPRSGKVLEFSCPPP 413


>UniRef50_A8UMR7 Pseudouridine synthase n=1 Tax=Flavobacteriales bacterium ALC-1
           RepID=A8UMR7_9FLAO
          Length = 561

 Score =  270 bits (693), Expect = 2e-71,   Method: Composition-based stats.
 Identities = 96/215 (44%), Positives = 131/215 (60%), Gaps = 14/215 (6%)

Query: 11  EPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ---AESVHRLDMAT 67
              L I+Y+DD ++V+NKP   LSVPG+  +  DSV+TR+Q   P       +HRLDM+T
Sbjct: 355 NGELEIIYEDDFLVVLNKPHEFLSVPGKTIK--DSVLTRMQNYLPDATGPLLLHRLDMST 412

Query: 68  SGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKV 127
           SG+++VA  +   + L++QF +R  KK+YVA + G   P+EG +DLPL  D  NRP+Q V
Sbjct: 413 SGLLLVAKNERTHKNLQKQFIKRIVKKRYVALLNGKLEPSEGTIDLPLRVDLNNRPRQLV 472

Query: 128 CYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLA---LGHPILGDRFYASP 184
           C E GK A+T+YEV+E   +N  R+   PITGR+HQLRVH      L  PI+GD  Y + 
Sbjct: 473 CDEHGKLAKTKYEVIE-IKNNKTRIHFYPITGRTHQLRVHAAHYKGLNMPIIGDDLYGTA 531

Query: 185 EARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
                  RL LHAEML+  HP     ++F   A F
Sbjct: 532 S-----NRLHLHAEMLSFEHPVKREWVSFSCKAPF 561


>UniRef50_Q12L72 Pseudouridine synthase n=17 Tax=Shewanella RepID=Q12L72_SHEDO
          Length = 230

 Score =  270 bits (693), Expect = 2e-71,   Method: Composition-based stats.
 Identities = 107/219 (48%), Positives = 136/219 (62%), Gaps = 2/219 (0%)

Query: 1   MGMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESV 60
           M + NY PP  PWL I Y D  I+V+NKPSGLLS PGR  E  D+ +TR+QR YP+   +
Sbjct: 14  MQVFNYQPPSIPWLDIRYLDRDIIVINKPSGLLSNPGRAPETYDTAITRLQRLYPETILI 73

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLD  TSG+++ A  K AE  LK QF+ R+ KK Y+A V G     +G V+ PL  D  
Sbjct: 74  HRLDCDTSGIMIFARNKKAESNLKTQFQNRQAKKVYIAEVSGCFEHQDGKVNFPLGPDPM 133

Query: 121 NRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRF 180
             P Q+V  E+GKPA T Y ++E+ A  T+ V LKP TGR+HQLRVHM ALGH I+GD F
Sbjct: 134 TPPFQQVI-ESGKPALTYYRLLEHRAS-TSLVELKPHTGRTHQLRVHMKALGHTIIGDEF 191

Query: 181 YASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
           Y      A + RL LHA+ LT+ HP     + F +   F
Sbjct: 192 YGDETVIAASHRLNLHAQSLTLLHPFKQIEIQFFSQHPF 230


>UniRef50_Q89AD9 Ribosomal large subunit pseudouridine synthase D n=1 Tax=Buchnera
           aphidicola (Baizongia pistaciae) RepID=RLUD_BUCBP
          Length = 317

 Score =  270 bits (691), Expect = 3e-71,   Method: Composition-based stats.
 Identities = 62/232 (26%), Positives = 106/232 (45%), Gaps = 20/232 (8%)

Query: 4   ENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRD-----YPQAE 58
           +N    +  +L ++Y+DD I+V+NK    +  PG        +   + RD      P+A 
Sbjct: 75  KNDYQAENIFLNVIYEDDDILVINKQDNFVVHPGAGNTSGTLLNALLHRDSTFFNIPRAG 134

Query: 59  SVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICD 118
            VHRLD  T+G++V+A    +   L  Q + ++  ++Y A V+G      G +   +I +
Sbjct: 135 IVHRLDKDTTGLMVIAKNNLSYMALIDQIKCKKVIREYQAIVYGKVISG-GTIVKSIIRN 193

Query: 119 WPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGD 178
              R    V  + GK A T Y +++    +   + +   TGR+HQ+R HML +  P++GD
Sbjct: 194 PIKRTTMIV-NKCGKRAITHYRILKRFTHH-THLKIILETGRTHQIRTHMLYINFPLVGD 251

Query: 179 RFYASP------------EARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           + Y +             E     PR  LHA  L + HP   + M + +   
Sbjct: 252 KTYGNKFKFYKNISLTLLEQVKKFPRQALHASRLCLYHPVTKHLMEWNSTLP 303


>UniRef50_B9DS29 Pseudouridine synthase n=85 Tax=Firmicutes RepID=B9DS29_STRU0
          Length = 301

 Score =  269 bits (689), Expect = 6e-71,   Method: Composition-based stats.
 Identities = 68/209 (32%), Positives = 100/209 (47%), Gaps = 12/209 (5%)

Query: 7   NPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDY-------PQAES 59
                  L I+Y+DDH +V+NKP G  S+P  +    +++   I+  Y        Q   
Sbjct: 69  LEAVPHPLDIVYEDDHFLVLNKPVGYASIPSAIHS--NTIANFIKAYYFEQNYPNKQVHI 126

Query: 60  VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPS-PAEGLVDLPLICD 118
           V RLD  TSG+++ A    A   L +Q ++R  +K+Y A V G+   P  G +  P+   
Sbjct: 127 VTRLDRDTSGLMLFAKHGYAHARLDKQLQKRSIEKRYFALVSGNGQLPDFGEIVEPIGRS 186

Query: 119 WPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGD 178
             +   + V    GK A+T YEVV   A+N   V +K  TGR+HQ+RVH   +G P+LGD
Sbjct: 187 KDSIITRTVD-PMGKYAKTTYEVVARFAENVHLVDIKLHTGRTHQIRVHFSHIGFPLLGD 245

Query: 179 RFYASPEARAMAPRLLLHAEMLTITHPAY 207
             Y          R  LH   L+  +P  
Sbjct: 246 DLYGGRMD-LGIERQALHCHFLSFFNPFT 273


>UniRef50_Q5E092 Pseudouridine synthase n=3 Tax=Aliivibrio RepID=Q5E092_VIBF1
          Length = 576

 Score =  268 bits (688), Expect = 7e-71,   Method: Composition-based stats.
 Identities = 87/218 (39%), Positives = 123/218 (56%), Gaps = 14/218 (6%)

Query: 8   PPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ---AESVHRLD 64
           P     L I+Y+DD +++VNKP   LSV G+     DSV  RIQ  YP       VHRLD
Sbjct: 367 PSYGKELEIVYEDDVLVIVNKPVEFLSVSGK--YISDSVHARIQARYPNATGPLIVHRLD 424

Query: 65  MATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPK 124
           M+TSG++V+ LT  + +++++QF ER  +K+Y A + G+     G ++LPL  D  +RP+
Sbjct: 425 MSTSGLLVLTLTAESNKQVQKQFIERTVEKRYTALLEGNIETDNGTINLPLTGDMEDRPR 484

Query: 125 QKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLA---LGHPILGDRFY 181
           Q V +++G+ A+T Y+V+        +V L P TGR+HQLRVH      L  PI+GD  Y
Sbjct: 485 QMVNHKSGRKAETHYQVIAQEGKR-TKVHLYPHTGRTHQLRVHCAHQAGLNTPIVGDDLY 543

Query: 182 ASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
                   A RL LHA  L   HP    ++ F  P DF
Sbjct: 544 GFK-----ADRLHLHAGYLKFKHPTTNETVEFSCPEDF 576


>UniRef50_D1W0M0 Pseudouridine synthase n=1 Tax=Prevotella timonensis CRIS 5C-B1
           RepID=D1W0M0_9BACT
          Length = 566

 Score =  268 bits (688), Expect = 7e-71,   Method: Composition-based stats.
 Identities = 93/214 (43%), Positives = 124/214 (57%), Gaps = 16/214 (7%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP---QAESVHRLDMATSGV 70
           L ++Y+DD ++VV+KP+G+LSVPGR +    SV + ++   P   +  SVHRLDMATSG+
Sbjct: 351 LHVVYEDDALIVVDKPAGILSVPGRSQRP--SVYSILRSQMPSSVELFSVHRLDMATSGL 408

Query: 71  IVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYE 130
           +++A      R L+RQFR    +K+Y+A + G  S  EG+V LPL  D  +RP+Q V +E
Sbjct: 409 LILAKNSVVYRHLQRQFRTHHIQKEYIAILEGALSQREGVVTLPLRPDPFDRPRQVVDWE 468

Query: 131 TGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLA---LGHPILGDRFYASPEAR 187
            GK A T Y V+         V L P TGR+HQLR+H      L  PILGD  Y      
Sbjct: 469 HGKKAVTSYRVL-NVRHGKTWVALFPETGRTHQLRMHCAHAEGLNCPILGDPLYGH---- 523

Query: 188 AMAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
             A RL LHA  +T  HP  G  +T  A  PADF
Sbjct: 524 -HANRLYLHATSITFEHPISGQLLTLHAQPPADF 556


>UniRef50_D0MK65 Pseudouridine synthase n=1 Tax=Rhodothermus marinus DSM 4252
           RepID=D0MK65_RHOM4
          Length = 235

 Score =  268 bits (687), Expect = 8e-71,   Method: Composition-based stats.
 Identities = 71/207 (34%), Positives = 103/207 (49%), Gaps = 3/207 (1%)

Query: 12  PWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDMATSGVI 71
             L ILY+DD ++ V+KP GL ++P R      +          +   VHRLD   SGV+
Sbjct: 1   MELPILYEDDDLLAVHKPEGLAAIPERDPSRPSARRLLEAARGERLWVVHRLDKEASGVL 60

Query: 72  VVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYET 131
           + A    A R +   F +R+ +K Y A V G   P +G +  P+        +  V  E 
Sbjct: 61  LFARNAEAHRYMNTLFEQRQVRKVYRALVHGRLEPGQGQIRAPIR--MYGSGRMGVDPER 118

Query: 132 GKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARAMAP 191
           GKP++T Y V+EY  +  + +   P+TGR HQ+RVH   +GHPI+GD  Y     +   P
Sbjct: 119 GKPSETRYRVLEYLDEAYSLIEALPLTGRRHQIRVHCYHIGHPIVGDPRYGDRSVQQRYP 178

Query: 192 RLLLHAEMLTITHPAYGNSMTFKAPAD 218
           RL+LHA  +   HP  G  +   AP  
Sbjct: 179 RLMLHALSIRFRHP-NGQELEIVAPVP 204


>UniRef50_C5WJF2 Pseudouridine synthase n=104 Tax=Lactobacillales RepID=C5WJF2_STRDG
          Length = 341

 Score =  268 bits (687), Expect = 9e-71,   Method: Composition-based stats.
 Identities = 68/202 (33%), Positives = 105/202 (51%), Gaps = 5/202 (2%)

Query: 15  VILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ-AESVHRLDMATSGVIVV 73
             LY+DDH+++VNKP G+ +     E  + +++  +     +    VHRLDM TSGVIV 
Sbjct: 128 DCLYEDDHLIIVNKPEGMKTHGN--EPTELALLNHVSAYTGRTCYVVHRLDMETSGVIVF 185

Query: 74  ALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYETGK 133
           A T      L R   +RE  + Y A V G  S  E     P+     +R K+ V  + G+
Sbjct: 186 AKTPFILPILNRLLEKREISRDYWALVHGTLSSKEVSYREPIGRHRHDRRKRVVDVKQGQ 245

Query: 134 PAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARAMAPRL 193
            A T+ ++++    N + +  +  TGR+HQ+RVH+   GH +LGD  Y+  +A    PRL
Sbjct: 246 KAVTDVKLLKSFKQNVSLINCRLQTGRTHQIRVHLSHHGHALLGDPLYSKGKAE--CPRL 303

Query: 194 LLHAEMLTITHPAYGNSMTFKA 215
           +LHA  L + HP     +  +A
Sbjct: 304 MLHAHQLRLRHPLTQEMICVQA 325


>UniRef50_Q1CZL9 Pseudouridine synthase n=5 Tax=Proteobacteria RepID=Q1CZL9_MYXXD
          Length = 559

 Score =  268 bits (687), Expect = 1e-70,   Method: Composition-based stats.
 Identities = 90/212 (42%), Positives = 122/212 (57%), Gaps = 12/212 (5%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAE---SVHRLDMATSGV 70
           L I+++D+ ++VV KP GLLSVP +    +DSV+ R++   P+A      HRLD+ TSG+
Sbjct: 354 LDIVFEDEWLVVVEKPEGLLSVPAKDVSVEDSVLARLRARAPEAAGTMLAHRLDLDTSGL 413

Query: 71  IVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYE 130
           +V A        L+RQF  RE  K+Y A V G+     G +D P+  D  +RP+Q     
Sbjct: 414 LVAAKDARTYAALQRQFAGREVHKRYAAWVEGNVQGERGTIDFPMRVDLDDRPRQIHDPV 473

Query: 131 TGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLA---LGHPILGDRFYASPEAR 187
            GKPA TE+ V+E +     +V L P+TGR+HQLRVH      LG PI+GDR Y  P   
Sbjct: 474 HGKPAVTEWHVLERSHGR-TKVALFPLTGRTHQLRVHAAHPLGLGAPIVGDRLYGHPG-- 530

Query: 188 AMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
              PRL LHAE L+  HP  G  +T + PA F
Sbjct: 531 ---PRLHLHAEALSFQHPVTGQRLTLERPAPF 559


>UniRef50_B7GAM3 Predicted protein (Fragment) n=1 Tax=Phaeodactylum tricornutum CCAP
           1055/1 RepID=B7GAM3_PHATR
          Length = 325

 Score =  268 bits (687), Expect = 1e-70,   Method: Composition-based stats.
 Identities = 66/228 (28%), Positives = 103/228 (45%), Gaps = 23/228 (10%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP--------QAESVH 61
           Q+  L I+++D+H++V+NK + ++  P         V+  +             +   VH
Sbjct: 69  QDLPLDIIFEDEHMIVINKAANMVVHPAAGNWDGT-VVNALAYYLANRSESISFRPGIVH 127

Query: 62  RLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPN 121
           RLD  T+GV+VVA T      L   F  R+ KK Y+A   G+P     ++D P+     +
Sbjct: 128 RLDKGTTGVLVVAKTSQTLATLSNFFAARQVKKTYMAITVGNP-GKHVVIDKPIGRHPLH 186

Query: 122 RPKQKVCYE------TGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPI 175
           R + +V  +      TG+ A +  + +       + V ++  TGR+HQ+RVH+     PI
Sbjct: 187 RQRMRVVPDPHQKNSTGRRALSYVDTLA-FDGKLSLVQVRIETGRTHQIRVHLQDRHTPI 245

Query: 176 LGDRFYASPEARAMAP------RLLLHAEMLTITHPAYGNSMTFKAPA 217
            GD  Y   +            R LLHA  L I HP  G  M FKA  
Sbjct: 246 YGDDIYGLADWNKKLSKTHRIVRPLLHAYKLEINHPVTGEPMVFKASL 293


>UniRef50_C7GZW0 Pseudouridine synthase n=1 Tax=Eubacterium saphenum ATCC 49989
           RepID=C7GZW0_9FIRM
          Length = 318

 Score =  268 bits (686), Expect = 1e-70,   Method: Composition-based stats.
 Identities = 67/224 (29%), Positives = 115/224 (51%), Gaps = 12/224 (5%)

Query: 2   GMENYNPPQE-PWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR-----DYP 55
              +Y  P     +  +Y+D+H++V++KP+G++  P    E        I       +  
Sbjct: 83  KESSYFTPYSGIEINAVYEDEHLLVIDKPAGIVVHPTHGYEENTIAHALIHYMDTVGEEF 142

Query: 56  QAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPL 115
           +   ++RLDM T+G++++A  +  +  +  + +    +K+Y+A V G P   EG++D P+
Sbjct: 143 KIRFINRLDMDTTGLLMIAKNQFIQNAVVSEMKRGNVEKRYLAVVHGLPCNREGIIDAPI 202

Query: 116 ICDWPNRPKQKVCYETGKPAQTEYEVVEYAAD-NTARVVLKPITGRSHQLRVHMLALGHP 174
                   +Q    E GKP+ TEY+VV  + + N + + ++  TGR+HQ+RVH+  +G P
Sbjct: 203 KAVEGEPRRQ--VMEGGKPSITEYKVVGVSDELNVSFLDVRLHTGRTHQIRVHLKHIGCP 260

Query: 175 ILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           ILGD FY   E+   A R LLH+  L  THP     +   A   
Sbjct: 261 ILGDEFYGGKES---ADRQLLHSRYLRFTHPVSKKIVELTANLP 301


>UniRef50_Q38W13 Pseudouridine synthase n=4 Tax=Lactobacillus RepID=Q38W13_LACSS
          Length = 300

 Score =  268 bits (686), Expect = 1e-70,   Method: Composition-based stats.
 Identities = 63/214 (29%), Positives = 105/214 (49%), Gaps = 12/214 (5%)

Query: 12  PWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ-------AESVHRLD 64
             + +LY+DD+ +VVNKP+GL ++PG      D+++ RI+  + Q          + RLD
Sbjct: 77  VPIKVLYEDDYWLVVNKPAGLATIPGPTNTT-DTLLNRIKGYWQQNGATDLVPHIITRLD 135

Query: 65  MATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPK 124
             TSG+++ A  + A+  L+ Q  + + +K Y+A V G   P  G +  P+        +
Sbjct: 136 FDTSGIVLAAKHQVAQSLLQPQIEQHQLQKFYLAVVAGTGLPEFGTIKAPIGRVGVEPRR 195

Query: 125 QKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASP 184
           + +    G+ A T+Y  +    +    + ++  TGR+HQ+RVH+  L HP++GD+ Y   
Sbjct: 196 RVI--ADGQSAWTDYWRLAQD-ERLTVLKVQIHTGRTHQIRVHLSDLDHPLVGDQLY-EG 251

Query: 185 EARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
                  R  LHA  LT   P       F AP  
Sbjct: 252 PLGWGIDRQALHAYQLTFNDPFSQQKRQFTAPIP 285


>UniRef50_C0E4Q3 Pseudouridine synthase n=2 Tax=Corynebacterium matruchotii
           RepID=C0E4Q3_9CORY
          Length = 310

 Score =  268 bits (686), Expect = 1e-70,   Method: Composition-based stats.
 Identities = 74/216 (34%), Positives = 101/216 (46%), Gaps = 13/216 (6%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDY--------PQAESVHRLDM 65
           L ILY D+ ++ V+KP G+ + P    +    V       Y         +   V RLD+
Sbjct: 83  LEILYADEDLIAVDKPVGVAAHPTVGWDGPTVVGGLAAAGYRISTSGPPERNGIVQRLDV 142

Query: 66  ATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQ 125
            TSGV+VVA ++     LKR F+ER   K Y A V GH  P  G ++  +     +  K 
Sbjct: 143 GTSGVMVVAASERGYSVLKRAFKERTVSKTYHALVQGHMDPLAGTIEANIGRHPSSGWKF 202

Query: 126 KVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPE 185
            V    GK A T YE +E      + + +   TGR+HQ+RVHM AL HP  GD  Y +  
Sbjct: 203 AV-TSDGKHAVTHYETLEAFVA-ASLLEVHLETGRTHQIRVHMSALHHPCCGDPMYGADP 260

Query: 186 ---ARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
              AR    R  LHA  L   HPA G  +  ++P  
Sbjct: 261 QLSARLGLNRQWLHAVKLGFYHPADGRWLEIESPYP 296


>UniRef50_A9IIW7 Pseudouridine synthase n=5 Tax=Bordetella RepID=A9IIW7_BORPD
          Length = 324

 Score =  267 bits (685), Expect = 1e-70,   Method: Composition-based stats.
 Identities = 69/219 (31%), Positives = 100/219 (45%), Gaps = 11/219 (5%)

Query: 9   PQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRD-----YPQAESVHRL 63
           P+     ++ +    +VV+KP+GL++ PG        +   + R        +A  VHRL
Sbjct: 94  PEPIAFAVVAESPDWIVVDKPAGLVTHPGAGNWSGTLLNGLLHRYPELARVARAGIVHRL 153

Query: 64  DMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRP 123
           D  TSG++VVA  + A+  L RQ + R   ++Y+A   G   P  G VD P+  D     
Sbjct: 154 DKDTSGLMVVARNELAQTHLVRQLQARSMGREYIALAHGWL-PVAGKVDRPIGRDARVPV 212

Query: 124 KQKVCYETG-KPAQTEYEVVEYAA---DNTARVVLKPITGRSHQLRVHMLALGHPILGDR 179
           +  V      KPA T Y  +            V  +  TGR+HQ+RVH+ +LGHP+L D 
Sbjct: 213 RMSVERPIAPKPAITHYAPLRRGRAPDGPVTEVACRLETGRTHQIRVHLASLGHPLLADT 272

Query: 180 FYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
            Y      A A R +LHA  L    P  G    F+A   
Sbjct: 273 LYGGRLT-AGATRQMLHARALHFDDPGGGGPAAFRADPP 310


>UniRef50_B0JGC2 Pseudouridine synthase n=2 Tax=Microcystis aeruginosa
           RepID=B0JGC2_MICAN
          Length = 501

 Score =  267 bits (685), Expect = 2e-70,   Method: Composition-based stats.
 Identities = 83/207 (40%), Positives = 121/207 (58%), Gaps = 6/207 (2%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDMATSGVIVV 73
           L I+Y+D+ I+ +NKP+GLLSV GR ++ +D+V+ R +R       VHRLD  TSG++++
Sbjct: 300 LEIIYEDEGIIAINKPAGLLSVAGRYQDSQDAVVNRFRRQGKNLIPVHRLDRETSGILLL 359

Query: 74  ALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYETGK 133
           A +    R L +QF+ RE +K Y A +        G++DLPL  +  NRP Q V ++ GK
Sbjct: 360 AKSLDIYRCLSQQFQRREVEKIYEAILSEIIERESGIIDLPLWGNPQNRPYQTVDWQRGK 419

Query: 134 PAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLA-LGHPILGDRFYASPEARAMAPR 192
            +QT ++VV     N +R+   P TGR+HQ+RVH    LG  ILGDR Y   ++     R
Sbjct: 420 ASQTYFKVVGKEG-NYSRLEFIPYTGRTHQIRVHSQQGLGIGILGDRLYNGKQS----DR 474

Query: 193 LLLHAEMLTITHPAYGNSMTFKAPADF 219
           L LHA+ L+  HP   N +    P  F
Sbjct: 475 LHLHAKQLSFRHPQTENKLDLIIPTPF 501


>UniRef50_B7GQ28 Pseudouridine synthase, RluA family n=21 Tax=Bifidobacteriaceae
           RepID=B7GQ28_BIFLI
          Length = 320

 Score =  267 bits (684), Expect = 2e-70,   Method: Composition-based stats.
 Identities = 63/229 (27%), Positives = 103/229 (44%), Gaps = 14/229 (6%)

Query: 2   GMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDY------- 54
             +    P    + ++Y+DD ++VV+KP G+ +          +V+  ++          
Sbjct: 65  EEQAGPEPIATDMAVVYEDDDVIVVDKPVGVAAHASVG-WTGPTVLGSLRDRGVHIASYG 123

Query: 55  --PQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVD 112
              +   V RLD+ TSG+++V  +  A  E++RQF E E KK Y A V G     +  ++
Sbjct: 124 AAGREGIVSRLDVGTSGLMLVCKSDLAYTEMRRQFAEHEVKKTYHALVQGGLKENKATIE 183

Query: 113 LPLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALG 172
            P+     +  +  V    GKPA T ++V+E        V +   TGR+HQ+RVH  ++G
Sbjct: 184 APIGRAKVSDFRFCV-TPAGKPAVTHWDVLERFGHEATLVSVNLETGRTHQIRVHFSSIG 242

Query: 173 HPILGDRFYASPE---ARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           HP+ GD  Y +           R  LHA  L   HP      T ++   
Sbjct: 243 HPLCGDPMYGANPVLSEALGLDRQWLHAMKLEFRHPRTRVWTTVRSQYP 291


>UniRef50_B1XN95 Pseudouridine synthase n=1 Tax=Synechococcus sp. PCC 7002
           RepID=B1XN95_SYNP2
          Length = 538

 Score =  267 bits (684), Expect = 2e-70,   Method: Composition-based stats.
 Identities = 86/219 (39%), Positives = 127/219 (57%), Gaps = 12/219 (5%)

Query: 4   ENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRL 63
           ++     E  L I+Y+D  ++ ++KP+GL S+PGR  +  DS  +R++RDY     VHRL
Sbjct: 329 QDILTIPEIPLEIIYEDHSLIAIHKPAGLPSIPGRSSQTYDSAFSRLRRDYQDIFLVHRL 388

Query: 64  DMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRP 123
           D  TSG+++ A     +++L+ QFR R+  K+Y A +       EG++ LPL  D  +RP
Sbjct: 389 DQDTSGILLFAKNAETQQDLQTQFRRRKIHKEYEALLEEKIQRPEGMITLPLWADPGDRP 448

Query: 124 KQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLA---LGHPILGDRF 180
           +QKV  + GKP++T +  ++       R+ LKPITGR+HQLRVH      L +PILGDR 
Sbjct: 449 RQKVDAQRGKPSETYFVKLDSH-----RLKLKPITGRTHQLRVHCAHPNGLNNPILGDRL 503

Query: 181 YASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
           Y +      APRL L A  LT  HP   N  T ++  +F
Sbjct: 504 YGNRA----APRLHLQATALTFMHPETKNPHTIQSAPEF 538


>UniRef50_C8PT91 Ribosomal large subunit pseudouridine synthase D n=1 Tax=Treponema
           vincentii ATCC 35580 RepID=C8PT91_9SPIO
          Length = 326

 Score =  267 bits (683), Expect = 3e-70,   Method: Composition-based stats.
 Identities = 70/242 (28%), Positives = 109/242 (45%), Gaps = 28/242 (11%)

Query: 4   ENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR----------- 52
            ++  P+   L ILY+D+ ++ VNK  G+++ P         V                 
Sbjct: 69  PDFLIPEHIPLQILYEDNDVIAVNKRVGMVTHPAAGNWTGTLVQALAYYRLHTSPIHDKF 128

Query: 53  --------------DYPQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVA 98
                         D  +A  VHRLD  TSGV++ A + AAE  LK +F+ R  +K Y A
Sbjct: 129 AGLLEAEQGRGNFEDLLRAGIVHRLDKDTSGVLITARSAAAEAFLKDEFKMRRTEKYYAA 188

Query: 99  RVWGHPSPAEGLVDLPLICDWPNRPKQKVCYE--TGKPAQTEYEVVEYAADNTARVVLKP 156
            + G P    G+++  +  D  +R +     +   GK A++ Y+V+       A V+ K 
Sbjct: 189 ILNGVPEKRTGVIETSVFRDEHSRIRFTASADLAKGKYARSRYKVLRVYG-RYALVLFKI 247

Query: 157 ITGRSHQLRVHMLALGHPILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAP 216
            TGR+HQ+R+H   +G PI+GD  Y   EA      ++LHA  L +  P+      F AP
Sbjct: 248 DTGRTHQIRLHARFIGCPIVGDPLYGKKEAEWKPYGMMLHAYRLCVALPSTREKTVFTAP 307

Query: 217 AD 218
             
Sbjct: 308 LP 309


>UniRef50_D1PDP7 Pseudouridine synthase n=1 Tax=Prevotella copri DSM 18205
           RepID=D1PDP7_9BACT
          Length = 556

 Score =  267 bits (683), Expect = 3e-70,   Method: Composition-based stats.
 Identities = 93/220 (42%), Positives = 120/220 (54%), Gaps = 22/220 (10%)

Query: 17  LYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ---AESVHRLDMATSGVIVV 73
           LY+D  + V+ KP GLLSVPG+      SV   ++R Y +      VHRLDMATSG++++
Sbjct: 342 LYEDRELAVIYKPEGLLSVPGKDAAQP-SVYALMRRKYQEATGPLIVHRLDMATSGLMII 400

Query: 74  ALTKAAERELKRQFREREPKKQYVARVWGHPSPA-----------EGLVDLPLICDWPNR 122
           A T+ A   L+++F     +K+YVA V G    +            G + LPLI D+ +R
Sbjct: 401 AKTEFAYHRLQKEFLNHRVQKKYVAIVCGKDKESCNRILKEAEGGRGYISLPLIADFLDR 460

Query: 123 PKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLA---LGHPILGDR 179
           P+Q V  E GK A TEYEV+E   D   R+ L P TGR+HQLRVH      L  PI+GD 
Sbjct: 461 PRQMVNREQGKEAITEYEVLERIDDTHLRLALYPKTGRTHQLRVHCAHQEGLNAPIIGDP 520

Query: 180 FYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
            Y        A RL LHAE +T  HP  G  MT    ADF
Sbjct: 521 LYG----NEPATRLHLHAEEITFEHPMTGKKMTVTRKADF 556


>UniRef50_P70870 Ribosomal large subunit pseudouridine synthase D n=23 Tax=Borrelia
           RepID=RLUD_BORBU
          Length = 326

 Score =  266 bits (682), Expect = 3e-70,   Method: Composition-based stats.
 Identities = 70/208 (33%), Positives = 105/208 (50%), Gaps = 11/208 (5%)

Query: 5   NYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR----------DY 54
           +   P    + I+Y+D +++V+NKP G+LS PG        V   +            + 
Sbjct: 75  DCLRPSNIPIAIIYEDSNVIVLNKPQGILSHPGISHWDDTVVNFLLYHIKSLKINFNEEK 134

Query: 55  PQAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLP 114
            +   VHRLD  TSGV++ A   +  R L +QF+++   K Y+A V G+ +   G ++  
Sbjct: 135 IRPGIVHRLDKDTSGVLICAKNISTLRFLAQQFKDKRTNKVYIAIVKGNFNSFFGSIESF 194

Query: 115 LICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHP 174
           +  D  NR K  V  + GK A TEY ++    +  + + LKP TGR+HQLRVHM  L  P
Sbjct: 195 IDRDKHNRKKFSVSKDRGKKALTEYRLLLNFGE-YSLLALKPKTGRTHQLRVHMKYLNFP 253

Query: 175 ILGDRFYASPEARAMAPRLLLHAEMLTI 202
           ILGD  Y   +       L+LH+  L I
Sbjct: 254 ILGDEVYGRVDGSLKKITLMLHSYKLEI 281


>UniRef50_B5Y8D7 Pseudouridine synthase n=1 Tax=Coprothermobacter proteolyticus DSM
           5265 RepID=B5Y8D7_COPPD
          Length = 315

 Score =  266 bits (682), Expect = 3e-70,   Method: Composition-based stats.
 Identities = 64/221 (28%), Positives = 111/221 (50%), Gaps = 13/221 (5%)

Query: 7   NPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP---------QA 57
             P +    ++Y D+H+ V++KP  L+  P    +   ++   + +D+P         + 
Sbjct: 77  LQPADVEYSVVYYDEHLAVIDKPPNLVVHPAPSVK-GLTLCHGLLKDFPQVKNVGSAERP 135

Query: 58  ESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLIC 117
             VHRLD  TSG+++VAL++     L +   E+   ++Y+  V+G  +     VD P+  
Sbjct: 136 GIVHRLDKDTSGLMLVALSEKGYAGLTKMISEKSVSRKYLVAVYG-VANRPFEVDAPIGR 194

Query: 118 DWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILG 177
           D  N  +  V    GK A T +  V+   +  + +  +  TGR+HQ+RVH+   G  +LG
Sbjct: 195 DPRNPTRMAVV-PHGKNAYTRFRPVQCL-EKVSLLEAELFTGRTHQIRVHLSHAGFYVLG 252

Query: 178 DRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           D  Y + E+R +APR+ LH+  L + HP  G  + F +P  
Sbjct: 253 DPVYGNVESRLLAPRVFLHSYYLELEHPITGERLFFVSPLP 293


>UniRef50_UPI0001C37137 ribosomal large subunit pseudouridine synthase D n=1 Tax=Chlamydia
           muridarum Nigg RepID=UPI0001C37137
          Length = 338

 Score =  266 bits (682), Expect = 4e-70,   Method: Composition-based stats.
 Identities = 65/233 (27%), Positives = 93/233 (39%), Gaps = 19/233 (8%)

Query: 2   GMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ----- 56
              +   P+   L  +Y+D+ I+V+NKP  ++  P         V   +     +     
Sbjct: 80  ETPSSLTPENIPLDKVYEDNMILVINKPRNMVVHPAPGHVQGTVVHALLHEIGERLKQEF 139

Query: 57  ------AESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGL 110
                    VHRLD  TSG+++   T+ A+      F  ++ KK Y+A     P+     
Sbjct: 140 PEEPWRPGIVHRLDKDTSGLLITVKTRRAKAVYSELFSSKQMKKMYIAICINSPAQKH-- 197

Query: 111 VDLPLICDWPNRPKQKV---CYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVH 167
           +   +      R +  V     E GK A T   V+       + V L P TGR+HQLRVH
Sbjct: 198 IHTRIARHPVKRKEMTVLSKDTEGGKEAITHCHVLASNG-RLSVVALYPETGRTHQLRVH 256

Query: 168 MLALGHPILGDRFYASPEA--RAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           M  LG PILGD  Y  P    R    +  LHA  L  THP     +       
Sbjct: 257 MKHLGTPILGDPVYGVPSINFRYGLDKQQLHAYSLVFTHPESAERVELVTKLP 309


>UniRef50_B2KBB0 Pseudouridine synthase n=1 Tax=Elusimicrobium minutum Pei191
           RepID=B2KBB0_ELUMP
          Length = 299

 Score =  266 bits (682), Expect = 4e-70,   Method: Composition-based stats.
 Identities = 71/223 (31%), Positives = 113/223 (50%), Gaps = 27/223 (12%)

Query: 16  ILYQDDHIMVVNKPSGLLSVPGRLEEHKD---------SVMTRIQRDYP--------QAE 58
           I+++D ++ V+NKPSG+L  P      ++         ++++ I  + P        +A 
Sbjct: 77  IIFEDKNMFVINKPSGMLVHPQSPVWEENPAAAFIGEETLVSLILANPPKNFEKGITRAG 136

Query: 59  SVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICD 118
            VHRLD  TSGV+++A     +  +   F  RE  K Y A V G     +G++++P+   
Sbjct: 137 LVHRLDKDTSGVMIIAKNSKTQDAMVEMFANREMHKTYEAIVCGVVPDDKGIINVPIGRV 196

Query: 119 WPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGD 178
              + K     E G+ A TEY V++   +  + + L P+TGR++QLRVHM  LG+P+LGD
Sbjct: 197 TGGKIK---ASELGREAVTEYSVLQR-KETVSLMKLHPVTGRTNQLRVHMSWLGYPVLGD 252

Query: 179 RFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
             Y        APRL+LH++     HP     + F    P DF
Sbjct: 253 WLYKGAT----APRLMLHSKSAEFEHPFTSKPVKFTVAPPKDF 291


>UniRef50_Q26D11 Pseudouridine synthase n=2 Tax=Flavobacteria RepID=Q26D11_9BACT
          Length = 561

 Score =  266 bits (681), Expect = 4e-70,   Method: Composition-based stats.
 Identities = 92/229 (40%), Positives = 129/229 (56%), Gaps = 18/229 (7%)

Query: 1   MGMENY----NPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ 56
           + +E+     NP  +  + ++Y+DD I++VNKP   LSVPG+  +  DSV +R++  YP 
Sbjct: 341 IEVEDNPLLINPGIDKTMEVIYEDDAIIIVNKPEEFLSVPGKTIK--DSVYSRLKELYPD 398

Query: 57  ---AESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDL 113
                 VHRLDM+TSG++V          ++ QF  R   K+YVA + G     EG+++L
Sbjct: 399 ATGPILVHRLDMSTSGILVATKNLEYYHFIQEQFINRTISKRYVALLNGVLENNEGMIEL 458

Query: 114 PLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLA--- 170
           PL  D  NRP Q VCYE GK A+T+Y+V+E   +    V   PITGR+HQLRVH      
Sbjct: 459 PLRVDLDNRPTQLVCYEYGKSARTKYQVLER-REKETLVHFYPITGRTHQLRVHAAHASG 517

Query: 171 LGHPILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
           L  PI+GD  Y +        RL LHAE +   HP    +++FKAP  F
Sbjct: 518 LNAPIVGDDLYGTAT-----NRLHLHAEFIKFIHPITHKTVSFKAPVPF 561


>UniRef50_C9KIU1 Pseudouridine synthase n=3 Tax=Veillonellaceae RepID=C9KIU1_9FIRM
          Length = 296

 Score =  266 bits (681), Expect = 4e-70,   Method: Composition-based stats.
 Identities = 71/221 (32%), Positives = 109/221 (49%), Gaps = 10/221 (4%)

Query: 4   ENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ-----AE 58
            +   P++  L I Y+DD++++VNKP+G L  P   E H       +             
Sbjct: 68  PSDIEPEDLPLDIRYEDDYLLIVNKPAGQLVHPTTKEAHGTLGNAVLYWYKAHGEHHAYH 127

Query: 59  SVHRLDMATSGVIVVALTKAAERELK-RQFREREPKKQYVARVWGHPSPAEGLVDLPLIC 117
            VHRLD  TSG++++A     + +L  R    +   ++Y+A + G  +P EGL+D P+  
Sbjct: 128 PVHRLDRNTSGLVLIAKVPQVQYKLTPRHGEGKLFHREYLALIEGELTPPEGLIDAPIAR 187

Query: 118 DWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILG 177
             P+   +KV    G+ A+T Y+ V+      + + L   TGR+HQ+RVH+  LGHP+LG
Sbjct: 188 ALPSIILRKV-SPDGQTARTHYDTVQTDG-KLSLIHLVLDTGRTHQIRVHLAHLGHPLLG 245

Query: 178 DRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           D  Y    AR    R  LHA  L   HP  G  +  + P  
Sbjct: 246 DDLYGGNLAR--IKRQALHAARLHFRHPMTGAEIDVQVPLP 284


>UniRef50_A0YGE0 Pseudouridine synthase n=1 Tax=marine gamma proteobacterium
           HTCC2143 RepID=A0YGE0_9GAMM
          Length = 221

 Score =  266 bits (681), Expect = 4e-70,   Method: Composition-based stats.
 Identities = 107/216 (49%), Positives = 138/216 (63%)

Query: 4   ENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRL 63
                P    + IL+ DD +++VNKP+GLLSVPGR   +KD ++TR+QR Y  A  VHRL
Sbjct: 5   PYIVKPCTEDVEILFTDDDLLLVNKPAGLLSVPGRHPANKDCLITRVQRQYADARIVHRL 64

Query: 64  DMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRP 123
           DM TSG++V+AL+  + R L + F ER+  K+Y A V+G       L+DLPL+CDWPNRP
Sbjct: 65  DMDTSGIMVLALSADSHRALSQLFAERKIIKEYEANVYGTIIDDHRLIDLPLLCDWPNRP 124

Query: 124 KQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYAS 183
           +QKV +  GK AQT  E V    D   RV+LKP+TGRSHQLRVH+  +GHPILG  FYA 
Sbjct: 125 RQKVDFHHGKNAQTWVERVSQHPDGWTRVLLKPVTGRSHQLRVHLAEIGHPILGCEFYAH 184

Query: 184 PEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
             A +MA RL LHA  L   HP  G ++   +   F
Sbjct: 185 QRAVSMADRLQLHATKLEFCHPNSGETILGISNCPF 220


>UniRef50_Q31HX2 Pseudouridine synthase n=1 Tax=Thiomicrospira crunogena XCL-2
           RepID=Q31HX2_THICR
          Length = 241

 Score =  266 bits (681), Expect = 5e-70,   Method: Composition-based stats.
 Identities = 97/201 (48%), Positives = 137/201 (68%), Gaps = 1/201 (0%)

Query: 16  ILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAESVHRLDMATSGVIVVAL 75
           +LY+DD I+VVNKP+GLLSVPG+  + + +++ ++Q+  P A  VHRLDM TSG++++A 
Sbjct: 29  VLYEDDDIIVVNKPAGLLSVPGKDLDPEMNLLAQVQKHVPTALIVHRLDMDTSGIMILAK 88

Query: 76  TKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYETGKPA 135
            KA+ R L  QF++R  +K Y A  +G PS ++G ++LP+ CDW NRP Q +  + GK A
Sbjct: 89  HKASHRHLSIQFQDRLTEKTYQAICFGKPSTSQGHLNLPMRCDWENRPLQIIDLKQGKAA 148

Query: 136 QTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPEARAMAPRLLL 195
            T +++     DN   V L P+TGRSHQLR+HM  LGHPILGD  YA P++ A + RLLL
Sbjct: 149 STHWKLTAQY-DNAFEVNLTPVTGRSHQLRLHMKMLGHPILGDNLYADPQSFAASKRLLL 207

Query: 196 HAEMLTITHPAYGNSMTFKAP 216
           HA  L +THP    +M F+ P
Sbjct: 208 HAASLKVTHPVTKKTMLFEHP 228


>UniRef50_Q04XF3 Pseudouridylate synthase, 23S RNA-specific n=4 Tax=Leptospira
           RepID=Q04XF3_LEPBL
          Length = 312

 Score =  265 bits (680), Expect = 6e-70,   Method: Composition-based stats.
 Identities = 55/221 (24%), Positives = 98/221 (44%), Gaps = 13/221 (5%)

Query: 6   YNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--------DYPQA 57
              P    L ++ + +  ++++KP G+ S  G  +     V   +             + 
Sbjct: 76  SLEPIPMTLPVVLEREDYLIIHKPPGIASHSGPGDRSPSLVNGLLHHFKELSKVGGEARP 135

Query: 58  ESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLIC 117
             VHRLD  T G++++A    A  +L   FR+RE +K+Y A + GH     G +DLP+  
Sbjct: 136 GIVHRLDKPTEGLMLIAKNDRAHGKLSELFRKREIEKKYYAWIQGHLPAETGTIDLPIAR 195

Query: 118 DWPNRPKQKVCYETGKPAQTEYEVVE----YAADNTARVVLKPITGRSHQLRVHMLALGH 173
               R K  V    G+ + T Y+V++     +    + V +   TGR+HQ+R+H  +   
Sbjct: 196 HPIERLKMTV-SPKGRKSVTHYKVLKYVNSRSGRKFSFVEVGLETGRTHQIRIHFQSQRC 254

Query: 174 PILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFK 214
           P++GD  Y+   ++  +  L L +  L    P  G  +   
Sbjct: 255 PVVGDLLYSRTGSQFESYGLQLLSYYLKFKDPFTGEMIEAT 295


>UniRef50_Q0F1Z5 Pseudouridine synthase n=1 Tax=Mariprofundus ferrooxydans PV-1
           RepID=Q0F1Z5_9PROT
          Length = 579

 Score =  265 bits (680), Expect = 7e-70,   Method: Composition-based stats.
 Identities = 85/214 (39%), Positives = 122/214 (57%), Gaps = 16/214 (7%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ---AESVHRLDMATSGV 70
           + I+Y+DD ++VVNKP+GL+S      E ++S+ +R+ + YPQ      VHRLDM TSG+
Sbjct: 374 IEIVYEDDQLLVVNKPAGLMS--TPGREIEESLFSRLAQRYPQIPELTLVHRLDMDTSGL 431

Query: 71  IVVALTKAAERELKRQFREREPKKQYVARVWGHPS--PAEGLVDLPLICDWPNRPKQKVC 128
           ++VA      + L++QF ER  +K Y A +       P +G ++LPL  D  +RP+Q VC
Sbjct: 432 LLVAKDLRTHKRLQKQFIERSVEKCYEAVLVKRLPAQPDQGRIELPLRVDLDDRPRQMVC 491

Query: 129 YETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLA---LGHPILGDRFYASPE 185
           Y+ GKPA T ++++    +   R+   P TGR+HQLRVH      L   I+GD  Y    
Sbjct: 492 YQHGKPATTRWQIIARENNR-TRIWFYPETGRTHQLRVHASHRDGLNAAIVGDGLYG--- 547

Query: 186 ARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
               A RL+LHA  L  THP     M F+ PA F
Sbjct: 548 --LPAERLMLHARRLCFTHPVSREPMVFELPAPF 579


>UniRef50_A9MGU8 Pseudouridine synthase n=1 Tax=Salmonella enterica subsp. arizonae
           serovar 62:z4,z23:-- RepID=A9MGU8_SALAR
          Length = 318

 Score =  265 bits (679), Expect = 8e-70,   Method: Composition-based stats.
 Identities = 66/197 (33%), Positives = 99/197 (50%), Gaps = 8/197 (4%)

Query: 1   MGMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRD-----YP 55
           +  E     Q+  L I+Y+DD I+V+NKP  L+  PG        +   +         P
Sbjct: 71  IDEEIRFEAQDIPLDIVYEDDDILVINKPRDLVVHPGAGNPDGTVLNALLHYYPPIADVP 130

Query: 56  QAESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPL 115
           +A  VHRLD  T+G++VVA T  A+  L    + RE  ++Y A   GH +   G V+ P+
Sbjct: 131 RAGIVHRLDKDTTGLMVVAKTVPAQTRLVESLQLREITREYEAVAIGHMTAG-GTVNEPI 189

Query: 116 ICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPI 175
                 R    V +  GKPA T Y ++E+   +  R+ L+  TGR+HQ+RVHM  + HP+
Sbjct: 190 SRHPTKRTHMSV-HPMGKPAVTHYRIMEHFRVH-TRLRLRLETGRTHQIRVHMAHITHPL 247

Query: 176 LGDRFYASPEARAMAPR 192
           +GD+ Y        A R
Sbjct: 248 VGDQVYGGRPRPPKAHR 264


>UniRef50_C1ZB48 Pseudouridine synthase, RluA family n=1 Tax=Planctomyces
           limnophilus DSM 3776 RepID=C1ZB48_PLALI
          Length = 325

 Score =  265 bits (678), Expect = 9e-70,   Method: Composition-based stats.
 Identities = 69/239 (28%), Positives = 103/239 (43%), Gaps = 28/239 (11%)

Query: 6   YNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDY---------PQ 56
           + PP+   L IL++DD ++V+NKP+GL++ P         ++  +Q             +
Sbjct: 74  FVPPEPTPLEILFEDDSLLVINKPAGLIAHPTGEIPDGT-LINAVQHYLDKQSTHPGLER 132

Query: 57  AESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLI 116
              VHRLD  TSG + +     + R L  QF+     K Y+A V G  +  + ++DLP+ 
Sbjct: 133 PGIVHRLDRDTSGAMAICKEHLSHRLLSIQFQLGRISKSYLALVEGVLTDDQLVIDLPIG 192

Query: 117 CDWPNRPKQKVCYETGKPAQ---TEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGH 173
                      C      AQ   T   VVE    +   V  KP TGR HQ+R+H+  +G 
Sbjct: 193 RAPGCSSALMSCRADALEAQASKTSLRVVERFPQH-TLVEAKPRTGRMHQIRIHLATIGF 251

Query: 174 PILGDRFY--ASP------------EARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           PI+GD FY                 +   +  R  LHA  L+  HP       F+AP  
Sbjct: 252 PIVGDEFYLKGGEIRPLVWPESERVQVSLLINRQALHAACLSFAHPLTNEWQDFQAPLP 310


>UniRef50_A3ZV48 Pseudouridine synthase n=1 Tax=Blastopirellula marina DSM 3645
           RepID=A3ZV48_9PLAN
          Length = 281

 Score =  265 bits (678), Expect = 9e-70,   Method: Composition-based stats.
 Identities = 78/232 (33%), Positives = 111/232 (47%), Gaps = 25/232 (10%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYP---------QAESV 60
               L I+YQDD I V+NKP+G+++ P +       +   ++  +P         +   V
Sbjct: 35  VNVHLDIIYQDDRIAVINKPAGMITHPAKGHWKGT-LTEGLKGQFPQLSTIGGPTRPGIV 93

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLD  TSGVIV+A   AA   LK QF++R  +K+Y A V G P     L++ P+     
Sbjct: 94  HRLDRDTSGVIVIAKDDAAHEFLKTQFQDRLTEKEYFAMVIGAPDRDRDLINEPVGPHPK 153

Query: 121 NRPKQKVC--YETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGD 178
            R +  +    + GK AQT YEV+E      A +   P TGR+HQ+RVH++  GHP+L D
Sbjct: 154 IRERMAIRRGDDEGKDAQTFYEVLERY-QGFAAIKALPKTGRTHQIRVHLMHAGHPVLCD 212

Query: 179 RFYA------------SPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
             Y               +   +  R  LHA  + I HP  G    F AP  
Sbjct: 213 PLYGSRRFLSLGELQHDDDRTVLLNRTALHAHRIAIAHPDDGEIREFIAPLP 264


>UniRef50_C7PHX6 Pseudouridine synthase n=1 Tax=Chitinophaga pinensis DSM 2588
           RepID=C7PHX6_CHIPD
          Length = 570

 Score =  265 bits (678), Expect = 9e-70,   Method: Composition-based stats.
 Identities = 91/224 (40%), Positives = 126/224 (56%), Gaps = 14/224 (6%)

Query: 2   GMENYNPPQEP-WLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR--DYPQAE 58
                  P+    L I+YQD+ ++VVNKPSGL SVPG     +DSV TR++      +  
Sbjct: 355 EDPLLRTPETVGELDIIYQDESVVVVNKPSGLRSVPG--VTIQDSVYTRLKHALGDIEPL 412

Query: 59  SVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICD 118
            VHRLDM TSG++VVA T+AA + ++RQF +R   K+Y A +      +EG +DLPL  D
Sbjct: 413 IVHRLDMDTSGLLVVAKTQAAHKHIQRQFLQRTVSKRYTALLSKVIDTSEGEIDLPLTAD 472

Query: 119 WPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLA---LGHPI 175
             NRP+Q VC+ TGK + T ++VV        ++   P+TGR+HQLR+H      L  PI
Sbjct: 473 LFNRPRQIVCFTTGKKSVTRWKVVTRY-QAMTKIDFWPLTGRTHQLRMHSAHPLGLNAPI 531

Query: 176 LGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
           +GD  Y        A R+ LHA  +  THP     ++F AP  F
Sbjct: 532 VGDDLYG-----TAAERMYLHAAHIEFTHPLSRQRISFDAPVTF 570


>UniRef50_D2EJM0 Pseudouridine synthase n=1 Tax=Pediococcus acidilactici 7_4
           RepID=D2EJM0_PEDAC
          Length = 304

 Score =  265 bits (678), Expect = 1e-69,   Method: Composition-based stats.
 Identities = 68/220 (30%), Positives = 114/220 (51%), Gaps = 13/220 (5%)

Query: 7   NPPQEPWL----VILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ----AE 58
            PP +P       +L+++D ++VVNKP+G+ +   +  E   S++  +Q  + +    A 
Sbjct: 74  LPPFDPDSSQSPDVLFENDDLLVVNKPAGIKTHANQPHELG-SMINFLQAYFAKKDSNAY 132

Query: 59  SVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICD 118
           +VHRLD  TSG ++VA        L RQ  ++  ++ Y+  V GH     G + LP+  D
Sbjct: 133 NVHRLDQWTSGALLVAKNPVVVPILSRQISQKLIQRTYLCVVEGHLKSRSGTITLPIGLD 192

Query: 119 WPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGD 178
             ++ K+++     +PA T Y+VV    +  + + ++  TGR+HQ+RVH+ ALGHPI+GD
Sbjct: 193 PHDQRKRQINGPGAQPATTHYQVVREFVER-SLLRVQLATGRTHQIRVHLAALGHPIVGD 251

Query: 179 RFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
             Y S    A    + LH+  +    P   +  T  AP  
Sbjct: 252 PLYNSLADGAP---MRLHSWQVKFPLPFSQSWQTVTAPVP 288


>UniRef50_D0BL50 Pseudouridine synthase n=1 Tax=Granulicatella elegans ATCC 700633
           RepID=D0BL50_9LACT
          Length = 296

 Score =  265 bits (678), Expect = 1e-69,   Method: Composition-based stats.
 Identities = 69/228 (30%), Positives = 104/228 (45%), Gaps = 14/228 (6%)

Query: 2   GMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQA---- 57
           G      P    L IL++DD++++VNKP G  S+P +L   + S+  R++          
Sbjct: 65  GEHETVVPSHIPLDILFEDDYLLIVNKPQGTASIPSQLHPDQ-SMANRVKGYLQTTRTQD 123

Query: 58  ---ESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGH-PSPAEGLVDL 113
                V RLD  T+GV++ A  +     + +  R +  +K Y A V          L+D 
Sbjct: 124 CVTHVVTRLDRDTTGVMMFAKHRVVHAWMDQALRNKTIQKTYHAIVTKQDVLKEHDLIDA 183

Query: 114 PLICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGH 173
           P+     +   + V    GKP+ TEY  +E    ++  V ++  TGR+HQ+RVH   LG 
Sbjct: 184 PIGRTDDSIINRCV-RPDGKPSLTEYW-LEETYQHSQLVKIRLHTGRTHQIRVHFSWLGC 241

Query: 174 PILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKA--PADF 219
           P+LGD  Y   +   +  R  LH   L   HP  G  M  KA  P D 
Sbjct: 242 PLLGDDLYGGEKIEPLM-RQALHCSQLDFVHPMTGEKMCVKALLPKDM 288


>UniRef50_A5VLP2 Pseudouridine synthase, RluA family n=13 Tax=Lactobacillus
           RepID=A5VLP2_LACRD
          Length = 290

 Score =  264 bits (677), Expect = 1e-69,   Method: Composition-based stats.
 Identities = 63/222 (28%), Positives = 110/222 (49%), Gaps = 13/222 (5%)

Query: 4   ENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDY-------PQ 56
           ++        L ++Y+DD+ +VV+KP+G+ S+PG   ++ D+V+ R++           +
Sbjct: 68  DDTVESSNEPLNVVYEDDNWLVVDKPAGVTSIPGPTVQN-DTVLNRVKGYLIANNSADLR 126

Query: 57  AESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLI 116
              + RLD  T G++++A    A   + +Q ++ +  K+Y A V G      G ++ P+ 
Sbjct: 127 PHLITRLDRFTGGLLLIAKHHIASSMISQQVQQHQMLKEYTALVEGQVMDEHGEINKPIG 186

Query: 117 CDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPIL 176
               +    +V  E G+ A TEY V E       RV ++  TGR+HQ+RVH  A+GH ++
Sbjct: 187 R--KDGQAARVIDENGQRALTEYWVEER-GAKWTRVRVRLHTGRTHQIRVHFAAIGHSLI 243

Query: 177 GDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           GD  Y    ++      LLHA  ++   P     MTF +   
Sbjct: 244 GDHLYGGDTSKY--DHQLLHASKISFNDPFTLKQMTFTSELP 283


>UniRef50_D2RJC8 Pseudouridine synthase, RluA family n=2 Tax=Veillonellaceae
           RepID=D2RJC8_ACIFE
          Length = 294

 Score =  264 bits (677), Expect = 1e-69,   Method: Composition-based stats.
 Identities = 61/223 (27%), Positives = 107/223 (47%), Gaps = 13/223 (5%)

Query: 2   GMENYNPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ----- 56
             +    P    L +LY+D+ ++VV+KP+G+L  P       D+++  +   + +     
Sbjct: 65  EEKAAVIPVHLPLSLLYEDEDLLVVDKPAGMLIHPTWSGAR-DTLVQAVGGYFRRTGQHC 123

Query: 57  -AESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPL 115
               ++RLD  T+GV++VA +  A+  L R     +  ++Y+A   G     +G ++ P+
Sbjct: 124 GIHPLYRLDRDTTGVLMVAKSAFAKHALTRD--HSQIYREYLAVCEGRWGIPQGRIEHPI 181

Query: 116 ICDWPNRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPI 175
                   +  V    G+PA TEY ++E   +    + +  +TGR+HQ+RVH    GHP+
Sbjct: 182 GRVAEGVDRWTV-RPDGRPAVTEYRILEENQE-WTVLKIHLLTGRTHQIRVHFAHEGHPL 239

Query: 176 LGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           +GD  Y + + R    R  LHA  +   HP  G  +   AP  
Sbjct: 240 VGDPLYGTKDGR--IARQALHAWTVRFRHPRTGEEILLTAPMP 280


>UniRef50_D2ELJ1 Pseudouridine synthase n=1 Tax=Pediococcus acidilactici 7_4
           RepID=D2ELJ1_PEDAC
          Length = 301

 Score =  264 bits (676), Expect = 2e-69,   Method: Composition-based stats.
 Identities = 65/229 (28%), Positives = 111/229 (48%), Gaps = 20/229 (8%)

Query: 7   NPPQEP---------WLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ- 56
            PP+            + ++Y+D   +VVNKP  L +V     +  D+++ R++  Y + 
Sbjct: 62  LPPEPGNPHVVRSRQPIDVIYEDQDYLVVNKPPFLPTVQSARNQT-DTLVNRVKNYYAER 120

Query: 57  ------AESVHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGL 110
                    V RLD  TSG+++ A  + A   + +  R+   +K Y+A   G  + + GL
Sbjct: 121 DYESQVVHVVTRLDQDTSGLVLFAKRRFAHTIMDQDLRQHRVQKYYLAMATGRFAQSHGL 180

Query: 111 VDLPLICDWPNRPKQKVCYE-TGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHML 169
           +D P+  D  +  K++V     GKP++TEY V+E   D  + + ++  TGR+HQ+RVH  
Sbjct: 181 IDAPIERDPASFIKRRVASAGNGKPSKTEYWVLEQ-TDTDSLLKVQLHTGRTHQIRVHFS 239

Query: 170 ALGHPILGDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
            L HP++GD  Y +  +     R  LH   L   +   G  +  +AP  
Sbjct: 240 ELHHPLIGDPLY-NETSFRSLQRQALHCFSLKFENVFRGKKIDVQAPIP 287


>UniRef50_C0X7U3 Pseudouridine synthase n=21 Tax=Enterococcus faecalis
           RepID=C0X7U3_ENTFA
          Length = 297

 Score =  264 bits (676), Expect = 2e-69,   Method: Composition-based stats.
 Identities = 67/216 (31%), Positives = 108/216 (50%), Gaps = 13/216 (6%)

Query: 11  EPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ-------AESVHRL 63
           +  + I+++DDH +VVNKP+G+ S+P +       +  R++  Y +          V RL
Sbjct: 75  DEPIEIVFEDDHFLVVNKPAGIASIPAQYHPSGT-MANRVKGYYKRQNYVNQVIHVVTRL 133

Query: 64  DMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSP--AEGLVDLPLICDWPN 121
           D  TSG+++ A    A   + ++ RE++  K Y A V G         L++ P+  D  +
Sbjct: 134 DRDTSGLMLFAKHGFAHALIDQELREKKVTKIYYALVGGAIEQLNEHQLIEKPIGRDLSS 193

Query: 122 RPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFY 181
             K++V  ETG+ A TEY + +  A   A V ++  TGR+HQ+RVH  A+G  +LGD  Y
Sbjct: 194 LLKRQVI-ETGQFASTEYWLAKRGAQAAA-VRIQLHTGRTHQIRVHFEAIGCSLLGDEMY 251

Query: 182 ASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPA 217
                +    R  LH   L  THP    ++   +P 
Sbjct: 252 HGKMDQ-GIERQALHCMELIFTHPFTKETVHLISPL 286


>UniRef50_C1AE05 Pseudouridine synthase n=1 Tax=Gemmatimonas aurantiaca T-27
           RepID=C1AE05_GEMAT
          Length = 476

 Score =  263 bits (675), Expect = 2e-69,   Method: Composition-based stats.
 Identities = 91/210 (43%), Positives = 118/210 (56%), Gaps = 8/210 (3%)

Query: 16  ILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAE---SVHRLDMATSGVIV 72
           ++Y+DDH++VVNKPSG+L+VPGR    +D VMTR++  YP A     VHRLD+ TSG+++
Sbjct: 269 VVYEDDHLLVVNKPSGMLTVPGRGPTMQDCVMTRLRARYPDATGQMVVHRLDLDTSGLLL 328

Query: 73  VALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYETG 132
            A        L+R F  RE  K YVA + G  +   G + LPL  D  +RP+       G
Sbjct: 329 AAKDPITASALQRLFSLREIDKHYVAWLDGVVTDDHGHIHLPLRMDVDDRPRNIHDPVFG 388

Query: 133 KPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLA---LGHPILGDRFYASPEARAM 189
           KPA TE++V+    D   RV   P TGR+HQLRVH      L  PI+GDR Y    A   
Sbjct: 389 KPAHTEWQVMAR-TDGRTRVRFTPHTGRTHQLRVHAAHPDGLDAPIVGDRLYG-RTAPDE 446

Query: 190 APRLLLHAEMLTITHPAYGNSMTFKAPADF 219
             RL LHAE L   HP  G  +  + PA F
Sbjct: 447 DERLQLHAERLAFVHPVSGAKVVVEQPAPF 476


>UniRef50_C7QW59 Pseudouridine synthase n=5 Tax=Cyanobacteria RepID=C7QW59_CYAP0
          Length = 551

 Score =  263 bits (675), Expect = 2e-69,   Method: Composition-based stats.
 Identities = 87/213 (40%), Positives = 122/213 (57%), Gaps = 10/213 (4%)

Query: 13  WLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQA---ESVHRLDMATSG 69
            + ++Y+D  I+ ++KPSGLLSVPGR  E  DSV+TR+Q   P A    +VHRLD  TSG
Sbjct: 343 EIKVIYEDQWIIAIDKPSGLLSVPGRYFETFDSVLTRLQNSLPDAQELRTVHRLDQDTSG 402

Query: 70  VIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCY 129
           ++++A  +   R L +QF +R+ +K Y A + G     EG++ LPL  D  NRP QKV +
Sbjct: 403 ILLLARDRYTHRHLSQQFAQRKVEKIYEAILAGSVMMNEGVIQLPLWGDPNNRPYQKVDW 462

Query: 130 ETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHM---LALGHPILGDRFYASPEA 186
           E GKP+ T+++V+    +N  R+   P+TGR+HQ+RVH      LG  ILGD  Y     
Sbjct: 463 ELGKPSITQFKVI-TTQENLTRIQFIPLTGRTHQIRVHAVDTQGLGSVILGDYLYGC--- 518

Query: 187 RAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
            A   RL LHA  L   HP    ++       F
Sbjct: 519 NAGVSRLHLHARELKFEHPQQQKTVHLYLETPF 551


>UniRef50_Q83G23 Pseudouridine synthase n=2 Tax=Tropheryma whipplei
           RepID=Q83G23_TROWT
          Length = 303

 Score =  263 bits (675), Expect = 2e-69,   Method: Composition-based stats.
 Identities = 68/210 (32%), Positives = 108/210 (51%), Gaps = 10/210 (4%)

Query: 14  LVILYQDDHIMVVNKPSGLLSVPGRLEEHKD---SVMTRIQRDYP--QAESVHRLDMATS 68
           L ++Y DD + V++KP+G+ +              +   +    P  +   VHRLD  TS
Sbjct: 76  LRVIYSDDDLFVIDKPAGVAAHASPGWCGPTVTGCLSGLLAACGPQDRQGIVHRLDANTS 135

Query: 69  GVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVC 128
           G++V+A +  A   LK  FR+R   K+Y A V G+P P+ G+++ P+  D  +R +  + 
Sbjct: 136 GLMVLAKSDLAYHNLKAAFRDRAIHKRYKALVQGYPDPSSGVINAPIGRDLKHRDRFCID 195

Query: 129 YETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPE--- 185
           Y  G+ A T+Y   E        + + P TGR+HQ+RVH  AL HP++GD  Y +     
Sbjct: 196 YS-GRDAVTQYSTEEVYP-GFTLLSVAPKTGRTHQIRVHFSALRHPLVGDVKYGADPVFS 253

Query: 186 ARAMAPRLLLHAEMLTITHPAYGNSMTFKA 215
            +    R  LHA  L+ THP  G  + F++
Sbjct: 254 QKVNLKRQWLHAYHLSFTHPVSGVFVEFES 283


>UniRef50_Q9KQH0 Ribosomal large subunit pseudouridine synthase C n=59
           Tax=Proteobacteria RepID=RLUC_VIBCH
          Length = 315

 Score =  263 bits (675), Expect = 2e-69,   Method: Composition-based stats.
 Identities = 73/208 (35%), Positives = 107/208 (51%), Gaps = 9/208 (4%)

Query: 16  ILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQ-AESVHRLDMATSGVIVVA 74
           I+Y+DDH++++NKPSG     G           R  R   +  E VHR+D  TSG+++VA
Sbjct: 97  IVYEDDHLLILNKPSGTAVHGGSGLHFGAIEALRALRPQARFLELVHRIDRDTSGILLVA 156

Query: 75  LTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKVCYETGKP 134
             ++A R L+ QFRE+  +K Y A V GH      +V+ PL+ +  N   +      GKP
Sbjct: 157 KKRSALRHLQAQFREKTVQKYYYALVMGHWDAECKVVNAPLLKNEVNSIVR--VNPNGKP 214

Query: 135 AQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASPE-----ARAM 189
           ++T + ++E  A+    V   P+TGR+HQ+RVH   +GHPI  D  Y         A+  
Sbjct: 215 SETRFRILEKFAE-ATLVQASPVTGRTHQIRVHTQYMGHPIAWDDRYGDRRFDAYTAQFG 273

Query: 190 APRLLLHAEMLTITHPAYGNSMTFKAPA 217
             RL LHA  +   HPA    +   AP 
Sbjct: 274 IERLFLHAANIQFVHPASEKKLEIHAPL 301


>UniRef50_Q31NG5 Pseudouridine synthase n=2 Tax=Synechococcus elongatus
           RepID=Q31NG5_SYNE7
          Length = 543

 Score =  263 bits (674), Expect = 3e-69,   Method: Composition-based stats.
 Identities = 86/222 (38%), Positives = 118/222 (53%), Gaps = 15/222 (6%)

Query: 7   NPP---QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAE---SV 60
            PP   +   L ILY+D  ++ + KP+GLLSVPG     + S +  +++ +P       V
Sbjct: 328 LPPSSDEPLELPILYEDADLLAIIKPAGLLSVPGTRGLQQASAIQLLRQQFPDLPTYCVV 387

Query: 61  HRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWP 120
           HRLD ATSG+++VA  +  +  L  QFR R+  K Y A + G P    G +DLPL  DW 
Sbjct: 388 HRLDQATSGILLVARNRPTQVALFEQFRRRQVHKVYEALLEGQPDCTAGTIDLPLRPDWT 447

Query: 121 NRPKQKVCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLA---LGHPILG 177
            RP Q V  + G+PA T Y  ++   D   R+ L+PITGR+HQLRVHM     LG PILG
Sbjct: 448 RRPYQLVDRDRGRPALTYYRCIDQTGDR-CRMELEPITGRTHQLRVHMAHPEGLGQPILG 506

Query: 178 DRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
           D  Y        + RL LHA  +   HP+  + +       F
Sbjct: 507 DDLYG-----QSSDRLYLHARSIRFRHPSQLDWIQLTTDTPF 543


>UniRef50_Q4A7R4 Pseudouridine synthase n=5 Tax=Mycoplasma hyopneumoniae
           RepID=Q4A7R4_MYCH7
          Length = 304

 Score =  263 bits (674), Expect = 3e-69,   Method: Composition-based stats.
 Identities = 62/222 (27%), Positives = 99/222 (44%), Gaps = 14/222 (6%)

Query: 7   NPPQEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQR-------DYPQAES 59
             P E    I++QD +++++NKP  L+  PG        V   I         D+ +   
Sbjct: 75  LEPAEIDFEIIFQDQNMILINKPKNLVVHPGVGNWKNTLVNGLISHFDSLEQLDHIRPGI 134

Query: 60  VHRLDMATSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDW 119
           VHRLD  T+G+++VA    A      +   R+ K+ Y A V G        ++LP+  D 
Sbjct: 135 VHRLDKDTTGLLLVAKNAKAHSFFVNELANRQIKRFYKAIVIGKVLHKFMKINLPIGRDL 194

Query: 120 PNRPKQKVCYETGKPAQTEYEVVEYA---ADNTARVVLKPITGRSHQLRVHMLALGHPIL 176
            N  K+ + +   KPA T  E++++      + + V  +  TGR+HQ+R+H+  +G+PI 
Sbjct: 195 KNPLKKTISFFNSKPAITNVELIKHFNYQNQDFSLVKCQLETGRTHQIRLHLAHIGYPIY 254

Query: 177 GDRFYASPEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           GD  Y             LHA  L       G S  F+A   
Sbjct: 255 GDPIYGKKIDELG---QRLHAYKLVFKD-LNGLSREFQADLP 292


>UniRef50_D1PU24 Pseudouridine synthase n=1 Tax=Prevotella bergensis DSM 17361
           RepID=D1PU24_9BACT
          Length = 421

 Score =  263 bits (674), Expect = 3e-69,   Method: Composition-based stats.
 Identities = 97/216 (44%), Positives = 124/216 (57%), Gaps = 18/216 (8%)

Query: 10  QEPWLVILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAE---SVHRLDMA 66
           +   L I+Y+DD + VV+KP+G+LSVPG+      SV+  ++R  P A     VHRLDMA
Sbjct: 218 ETHELKIVYEDDTLCVVDKPAGMLSVPGKGCRE--SVLDVMRRRCPDATGALVVHRLDMA 275

Query: 67  TSGVIVVALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQK 126
           TSG++VVA T  A REL+RQF  R  +K+YVA +   P   +G + LPL  D  +RP+Q 
Sbjct: 276 TSGLMVVAKTAEAYRELQRQFATRSVRKRYVAILSRQPREPKGEIALPLRPDLDDRPRQV 335

Query: 127 VCYETGKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLA---LGHPILGDRFYAS 183
           V    GKPA T YE+++       RV L P TGR+HQLRVH      L  PI GD  Y  
Sbjct: 336 VDSVYGKPALTHYEIID-----GCRVALYPRTGRTHQLRVHCAHRDGLDSPIKGDELYGR 390

Query: 184 PEARAMAPRLLLHAEMLTITHPAYGNSMTFKAPADF 219
                 A RL LHAE L   HPA G  + F + A F
Sbjct: 391 R-----AERLYLHAEWLAFRHPATGEEVEFTSVAPF 421


>UniRef50_Q8ZQ16 Ribosomal large subunit pseudouridine synthase C n=110
           Tax=Gammaproteobacteria RepID=RLUC_SALTY
          Length = 319

 Score =  263 bits (674), Expect = 3e-69,   Method: Composition-based stats.
 Identities = 82/214 (38%), Positives = 109/214 (50%), Gaps = 14/214 (6%)

Query: 16  ILYQDDHIMVVNKPSGLLSVPGRLEEHKDSVMTRIQRDYPQAE---SVHRLDMATSGVIV 72
           ILY+DDHI+V+NKPSG     G        V+  ++   P+A     VHRLD  TSGV++
Sbjct: 95  ILYEDDHILVLNKPSGTAVHGGSGLSFG--VIEGLRALRPEARFLELVHRLDRDTSGVLL 152

Query: 73  VALTKAAERELKRQFREREPKKQYVARVWGHPSPAEGLVDLPLICDWPNRPKQKV-CYET 131
           VA  ++A R L  Q RE+  +K Y+A V G        V  PL+ +     ++ V   + 
Sbjct: 153 VAKKRSALRSLHEQLREKGMQKDYLALVRGQWQSHVKTVQAPLLKNILQSGERIVRVSQE 212

Query: 132 GKPAQTEYEVVEYAADNTARVVLKPITGRSHQLRVHMLALGHPILGDRFYASP------- 184
           GKP++T ++V E  A     V   P+TGR+HQ+RVH    GHPI  D  Y          
Sbjct: 213 GKPSETRFKVEERYAF-ATLVRCSPVTGRTHQIRVHTQYAGHPIAFDDRYGDREFDQQLT 271

Query: 185 EARAMAPRLLLHAEMLTITHPAYGNSMTFKAPAD 218
           EA     RL LHA  L  THP  G  M  +AP D
Sbjct: 272 EAGTGLKRLFLHAAALKFTHPGTGEVMRIEAPMD 305


  Database: uniref50.fasta
    Posted date:  Mar 8, 2010 10:38 AM
  Number of letters in database: 1,040,396,356
  Number of sequences in database:  3,077,464
  
Lambda     K      H
   0.313    0.216    0.872 

Lambda     K      H
   0.267   0.0661    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 2,112,231,205
Number of Sequences: 3077464
Number of extensions: 134677480
Number of successful extensions: 256688
Number of sequences better than 1.0e-01: 250
Number of HSP's better than  0.1 without gapping: 3149
Number of HSP's successfully gapped in prelim test: 840
Number of HSP's that attempted gapping in prelim test: 242511
Number of HSP's gapped (non-prelim): 4629
length of query: 219
length of database: 1,040,396,356
effective HSP length: 124
effective length of query: 95
effective length of database: 658,790,820
effective search space: 62585127900
effective search space used: 62585127900
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (20.7 bits)
S2: 92 (39.4 bits)
