BLASTP 2.2.22 [Sep-27-2009] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Reference for compositional score matrix adjustment: Altschul, Stephen F., John C. Wootton, E. Michael Gertz, Richa Agarwala, Aleksandr Morgulis, Alejandro A. Schaffer, and Yi-Kuo Yu (2005) "Protein database searches using compositionally adjusted substitution matrices", FEBS J. 272:5101-5109. Reference for composition-based statistics starting in round 2: Schaffer, Alejandro A., L. Aravind, Thomas L. Madden, Sergei Shavirin, John L. Spouge, Yuri I. Wolf, Eugene V. Koonin, and Stephen F. Altschul (2001), "Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements", Nucleic Acids Res. 29:2994-3005. Query= batch____ (336 letters) Database: uniref50.fasta 3,077,464 sequences; 1,040,396,356 total letters Searching..................................................done Results from round 1 Score E Sequences producing significant alignments: (bits) Value UniRef50_B1KDM8 Dihydroorotate dehydrogenase n=26 Tax=Gammaprote... 443 e-123 UniRef50_P57443 Dihydroorotate dehydrogenase n=2 Tax=Proteobacte... 389 e-106 UniRef50_Q2Y5H8 Dihydroorotate dehydrogenase n=195 Tax=cellular ... 365 1e-99 UniRef50_Q8D370 Dihydroorotate dehydrogenase n=46 Tax=Gammaprote... 337 4e-91 UniRef50_B2UNA2 Dihydroorotate dehydrogenase n=8 Tax=Bacteria Re... 334 3e-90 UniRef50_B6J754 Dihydroorotate dehydrogenase n=26 Tax=Proteobact... 332 1e-89 UniRef50_A1WJ81 Dihydroorotate dehydrogenase n=250 Tax=Bacteria ... 330 3e-89 UniRef50_C9YAQ9 Dihydroorotate dehydrogenase n=2 Tax=cellular or... 313 6e-84 UniRef50_C0Z506 Dihydroorotate dehydrogenase n=8 Tax=Bacteria Re... 300 4e-80 UniRef50_A1WTJ3 Dihydroorotate dehydrogenase n=1 Tax=Halorhodosp... 299 7e-80 UniRef50_A5EV79 Dihydroorotate dehydrogenase n=3 Tax=Gammaproteo... 299 1e-79 UniRef50_A6H0L5 Dihydroorotate dehydrogenase n=28 Tax=Bacteria R... 285 2e-75 UniRef50_B4UG99 Dihydroorotate dehydrogenase n=23 Tax=Bacteria R... 281 3e-74 UniRef50_A9CK85 Dihydroorotate dehydrogenase n=16 Tax=Alphaprote... 272 2e-71 UniRef50_C2QE06 Dihydroorotate dehydrogenase n=3 Tax=Bacillus ce... 270 5e-71 UniRef50_B1ZSY3 Dihydroorotate oxidase n=3 Tax=Verrucomicrobia R... 263 9e-69 UniRef50_A9WDI1 Dihydroorotate dehydrogenase n=13 Tax=Bacteria R... 258 2e-67 UniRef50_Q1V0W4 Dihydroorotate dehydrogenase n=5 Tax=Bacteria Re... 258 3e-67 UniRef50_B6BWI2 Dihydroorotate oxidase n=1 Tax=beta proteobacter... 257 5e-67 UniRef50_A7NLW9 Dihydroorotate dehydrogenase n=18 Tax=Bacteria R... 256 6e-67 UniRef50_D1SB76 Dihydroorotate dehydrogenase n=2 Tax=Micromonosp... 256 6e-67 UniRef50_A5UX75 Dihydroorotate dehydrogenase n=1 Tax=Roseiflexus... 256 8e-67 UniRef50_Q056I9 Dihydroorotate dehydrogenase n=6 Tax=Leptospira ... 255 2e-66 UniRef50_D2S350 Dihydroorotate dehydrogenase n=2 Tax=Halobacteri... 252 2e-65 UniRef50_D2PV93 Dihydroorotate dehydrogenase n=1 Tax=Kribbella f... 250 5e-65 UniRef50_Q3IU78 Dihydroorotate dehydrogenase n=13 Tax=cellular o... 249 1e-64 UniRef50_B6R4R9 Dihydroorotate oxidase n=1 Tax=Pseudovibrio sp. ... 248 1e-64 UniRef50_Q2RX27 Dihydroorotate dehydrogenase n=14 Tax=cellular o... 247 4e-64 UniRef50_A5U4G5 Dihydroorotate dehydrogenase n=31 Tax=Corynebact... 246 7e-64 UniRef50_Q47RF2 Dihydroorotate dehydrogenase n=52 Tax=Bacteria R... 243 5e-63 UniRef50_Q7PYN9 AGAP002037-PA (Fragment) n=10 Tax=cellular organ... 243 9e-63 UniRef50_B0W4C3 Dihydroorotate dehydrogenase, mitochondrial n=2 ... 242 1e-62 UniRef50_P74782 Dihydroorotate dehydrogenase n=24 Tax=Bacteria R... 241 2e-62 UniRef50_Q827Q6 Dihydroorotate dehydrogenase n=12 Tax=Actinomyce... 241 3e-62 UniRef50_Q30R79 Dihydroorotate dehydrogenase n=10 Tax=Campylobac... 240 6e-62 UniRef50_A5EA61 Dihydroorotate dehydrogenase n=122 Tax=cellular ... 240 6e-62 UniRef50_C6NV76 Dihydroorotate dehydrogenase n=1 Tax=Acidithioba... 239 7e-62 UniRef50_C1EIH8 Dihydropryrimidine dehydrogenase n=1 Tax=Micromo... 239 8e-62 UniRef50_C6XQ80 Dihydroorotate dehydrogenase n=1 Tax=Hirschia ba... 238 3e-61 UniRef50_Q1GGD3 Dihydroorotate oxidase A n=18 Tax=Alphaproteobac... 237 4e-61 UniRef50_Q5PR57 Dihydroorotate dehydrogenase n=20 Tax=cellular o... 236 1e-60 UniRef50_B5Z6I2 Dihydroorotate dehydrogenase n=28 Tax=Campylobac... 233 6e-60 UniRef50_Q02127 Dihydroorotate dehydrogenase, mitochondrial n=39... 233 7e-60 UniRef50_B7G8S8 Predicted protein n=2 Tax=Bacillariophyta RepID=... 233 1e-59 UniRef50_B9L4A8 Dihydroorotate oxidase n=2 Tax=Thermomicrobia (c... 232 1e-59 UniRef50_C3XDT6 Dihydroorotate dehydrogenase n=4 Tax=Helicobacte... 231 4e-59 UniRef50_P32748 Dihydroorotate dehydrogenase, mitochondrial n=14... 231 4e-59 UniRef50_B7JXU8 Dihydroorotate dehydrogenase n=8 Tax=Cyanobacter... 229 9e-59 UniRef50_Q75XR0 Dihydroorotate dehydrogenase n=3 Tax=Eukaryota R... 227 4e-58 UniRef50_D2UZD6 Predicted protein n=1 Tax=Naegleria gruberi RepI... 227 5e-58 UniRef50_Q9RX14 Dihydroorotate dehydrogenase n=4 Tax=Bacteria Re... 227 5e-58 UniRef50_B9L9P6 Dihydroorotate dehydrogenase n=7 Tax=Epsilonprot... 226 7e-58 UniRef50_B9KHW9 Dihydroorotate dehydrogenase (PyrD) n=10 Tax=Ric... 226 8e-58 UniRef50_B3CMR9 Dihydroorotate dehydrogenase n=10 Tax=Rickettsia... 226 8e-58 UniRef50_B0MVX7 Putative uncharacterized protein n=1 Tax=Alistip... 226 1e-57 UniRef50_A8WW30 C. briggsae CBR-DHOD-1 protein n=3 Tax=Caenorhab... 225 2e-57 UniRef50_C4QIG2 Dihydroorotate dehydrogenase n=3 Tax=Schistosoma... 224 5e-57 UniRef50_Q5UF20 Predicted dihydroorotate dehydrogenase n=1 Tax=u... 223 6e-57 UniRef50_Q0J918 Os04g0676300 protein n=1 Tax=Oryza sativa Japoni... 223 8e-57 UniRef50_B3DX48 Dihydroorotate dehydrogenase n=1 Tax=Methylacidi... 223 8e-57 UniRef50_Q7RLG4 Dihydroorotate dehydrogenase, putative n=2 Tax=P... 221 2e-56 UniRef50_Q7U3U2 Dihydroorotate dehydrogenase n=30 Tax=cellular o... 220 5e-56 UniRef50_B3L830 Dihydroorotate dehydrogenase, putative n=1 Tax=P... 219 1e-55 UniRef50_Q75CE1 Dihydroorotate dehydrogenase, mitochondrial n=9 ... 218 2e-55 UniRef50_D1B1W1 Dihydroorotate dehydrogenase n=2 Tax=Campylobact... 218 2e-55 UniRef50_Q2YWG7 Dihydroorotate dehydrogenase n=56 Tax=Staphyloco... 218 3e-55 UniRef50_P32747 Dihydroorotate dehydrogenase, mitochondrial n=2 ... 216 7e-55 UniRef50_A9HBE5 Dihydroorotate oxidase n=10 Tax=Acetobacteraceae... 215 1e-54 UniRef50_C7NF21 Dihydroorotate oxidase A n=1 Tax=Kytococcus sede... 215 2e-54 UniRef50_Q0GF37 Dihydroorotate dehydrogenase n=2 Tax=Ustilago ma... 214 2e-54 UniRef50_B0CUF5 Predicted protein n=4 Tax=Dikarya RepID=B0CUF5_L... 214 4e-54 UniRef50_Q5HL43 Dihydroorotate dehydrogenase n=8 Tax=Staphylococ... 213 8e-54 UniRef50_Q2GEM2 Dihydroorotate dehydrogenase n=2 Tax=Neoricketts... 213 1e-53 UniRef50_Q08210 Dihydroorotate dehydrogenase homolog, mitochondr... 211 3e-53 UniRef50_A7BDH3 Putative uncharacterized protein n=1 Tax=Actinom... 211 3e-53 UniRef50_C2BWU0 Possible dihydroorotate oxidase n=3 Tax=Mobilunc... 210 5e-53 UniRef50_Q6SZS6 Dihydroorotate dehydrogenase, mitochondrial n=10... 210 7e-53 UniRef50_Q5KK62 Dihydroorotate dehydrogenase, mitochondrial, put... 207 5e-52 UniRef50_A9F3A8 PyrD protein n=1 Tax=Sorangium cellulosum 'So ce... 207 6e-52 UniRef50_B6KTR1 Dihydroorotate dehydrogenase n=4 Tax=Toxoplasma ... 206 1e-51 UniRef50_A5K1N1 Dihydroorotate dehydrogenase, mitochondrial, put... 204 3e-51 UniRef50_Q83GM4 Dihydroorotate oxidase n=2 Tax=Tropheryma whippl... 203 6e-51 UniRef50_D0IRU1 Dihydroorotate dehydrogenase n=1 Tax=Helicobacte... 202 1e-50 UniRef50_A6BB63 Dihydroorotate dehydrogenase n=1 Tax=Vibrio para... 201 2e-50 UniRef50_Q2S001 Dihydroorotate oxidase n=2 Tax=Rhodothermaceae R... 201 3e-50 UniRef50_C0W1V7 Possible dihydroorotate oxidase n=1 Tax=Actinomy... 201 4e-50 UniRef50_A7AUQ8 Dihydroorotate dehydrogenase n=2 Tax=Piroplasmid... 200 7e-50 UniRef50_D1CE91 Dihydroorotate dehydrogenase n=1 Tax=Thermobacul... 197 4e-49 UniRef50_C6IFT5 Dihydroorotate dehydrogenase 2 n=7 Tax=Bacteroid... 197 4e-49 UniRef50_A8Q682 Putative uncharacterized protein n=1 Tax=Malasse... 190 6e-47 UniRef50_B5CXJ8 Putative uncharacterized protein n=3 Tax=Bactero... 189 8e-47 UniRef50_A2VBP6 Dihydroorotate dehydrogenase, mitochondrial n=1 ... 181 5e-44 UniRef50_Q6MPX3 PyrD protein n=1 Tax=Bdellovibrio bacteriovorus ... 173 6e-42 UniRef50_Q00YC9 Dihydroorotate dehydrogenase (ISS) (Fragment) n=... 168 3e-40 UniRef50_B2B417 Predicted CDS Pa_6_7920 n=3 Tax=Sordariomycetes ... 167 7e-40 UniRef50_D1ZM19 Whole genome shotgun sequence assembly, scaffold... 164 3e-39 UniRef50_C5K5A0 Dihydroorotate dehydrogenase, putative n=2 Tax=P... 159 2e-37 UniRef50_Q4N5X1 Dihydroorotate dehydrogenase, putative n=1 Tax=T... 158 2e-37 UniRef50_C6A9A6 Dihydroorotate dehydrogenase 2 n=20 Tax=Bifidoba... 154 4e-36 UniRef50_Q2H299 Putative uncharacterized protein n=3 Tax=cellula... 141 3e-32 UniRef50_A3ZNL9 Dihydroorotate dehydrogenase n=2 Tax=Planctomyce... 139 2e-31 UniRef50_UPI00016B255A dihydroorotate dehydrogenase 2 n=4 Tax=ca... 137 7e-31 UniRef50_A2QCB1 Catalytic activity: n=26 Tax=Leotiomyceta RepID=... 134 3e-30 UniRef50_B9TAL5 Dihydroorotate dehydrogenase, putative n=1 Tax=R... 123 9e-27 UniRef50_B2WMQ8 Dihydroorotate dehydrogenase, mitochondrial n=3 ... 120 8e-26 UniRef50_UPI00016B240E dihydroorotate dehydrogenase 2 n=1 Tax=ca... 119 1e-25 UniRef50_Q0CXV7 Putative uncharacterized protein n=1 Tax=Aspergi... 115 3e-24 UniRef50_C9RJ75 Dihydroorotate oxidase n=1 Tax=Fibrobacter succi... 98 5e-19 UniRef50_Q2IVE7 Dihydroorotate oxidase B, catalytic subunit n=1 ... 97 6e-19 UniRef50_B3P4V6 GG16516 n=3 Tax=cellular organisms RepID=B3P4V6_... 94 8e-18 UniRef50_UPI000187EFAF hypothetical protein MPER_16226 n=1 Tax=M... 84 6e-15 UniRef50_A8MCA1 Dihydroorotate oxidase n=1 Tax=Caldivirga maquil... 83 1e-14 UniRef50_A8QCU3 Dihydroorotate dehydrogenase, mitochondrial, put... 82 2e-14 UniRef50_A5AEM5 Putative uncharacterized protein n=1 Tax=Vitis v... 82 3e-14 UniRef50_B2V726 Dihydroorotate dehydrogenase n=2 Tax=Aquificales... 80 8e-14 UniRef50_UPI0000D54A55 dihydroorotate dehydrogenase n=1 Tax=Psyc... 80 1e-13 UniRef50_C0ZGG5 Hypothetical membrane protein n=1 Tax=Brevibacil... 77 7e-13 UniRef50_C0QU30 Dihydroorotate dehydrogenase, catalytic subunit ... 77 8e-13 UniRef50_A6DND8 Dihydroorotate dehydrogenase n=1 Tax=Lentisphaer... 77 8e-13 UniRef50_Q0W8E1 Dihydroorotate dehydrogenase n=18 Tax=Euryarchae... 70 1e-10 UniRef50_A9BJH4 Dihydroorotate dehydrogenase n=45 Tax=Bacteria R... 69 3e-10 UniRef50_C6A1L2 Dihydroorotate dehydrogenase family protein n=1 ... 69 3e-10 UniRef50_C6QGW0 Dihydroorotate dehydrogenase n=1 Tax=Hyphomicrob... 69 3e-10 UniRef50_Q3AC05 Dihydroorotate dehydrogenase n=1 Tax=Carboxydoth... 68 4e-10 UniRef50_A0NIQ6 Dihydroorotate dehydrogenase A n=7 Tax=Lactobaci... 66 2e-09 UniRef50_D1JFH0 Dihydroorotate dehydrogenase electron transfer s... 66 2e-09 UniRef50_Q1G992 Dihydroorotate dehydrogenase n=3 Tax=Lactobacill... 65 4e-09 UniRef50_C6SRR7 Putative dihydroorotate dehydrogenase dihydrooro... 64 6e-09 UniRef50_Q1Q4L5 Similar to dihydroorotate oxidase (Dihydroorotat... 64 8e-09 UniRef50_A5IK84 Dihydroorotate dehydrogenase n=10 Tax=Thermotoga... 64 9e-09 UniRef50_B1MZ73 Dihydroorotate dehydrogenase B, catalytic subuni... 63 1e-08 UniRef50_B5YJH1 Dihydroorotate dehydrogenase n=24 Tax=Bacteria R... 63 2e-08 UniRef50_O27281 Dihydroorotate dehydrogenase n=20 Tax=Euryarchae... 63 2e-08 UniRef50_C2D6B3 Dihydroorotate oxidase n=1 Tax=Atopobium vaginae... 62 3e-08 UniRef50_Q73P17 Dihydroorotate dehydrogenase/oxidoreductase, FAD... 62 3e-08 UniRef50_A9A3M4 Dihydroorotate dehydrogenase family protein n=2 ... 62 4e-08 UniRef50_Q0B324 Dihydroorotate oxidase B, catalytic subunit n=8 ... 61 5e-08 UniRef50_D1YYV3 Dihydroorotate dehydrogenase n=1 Tax=Methanocell... 61 6e-08 UniRef50_B1I4M6 Dihydroorotate dehydrogenase n=73 Tax=Bacteria R... 60 8e-08 UniRef50_A4WLH6 Dihydroorotate dehydrogenase n=5 Tax=Thermoprote... 60 9e-08 UniRef50_C0WNB5 Dihydroorotate dehydrogenase n=3 Tax=Lactobacill... 60 9e-08 UniRef50_Q2NEG1 PyrD n=1 Tax=Methanosphaera stadtmanae DSM 3091 ... 60 9e-08 UniRef50_C1A4J6 Dihydroorotate dehydrogenase n=1 Tax=Gemmatimona... 60 1e-07 UniRef50_C8W700 Dihydroorotate dehydrogenase family protein n=2 ... 60 1e-07 UniRef50_Q8TXU6 Dihydroorotate dehydrogenase n=1 Tax=Methanopyru... 60 2e-07 UniRef50_B5YFH3 Dihydroorotate dehydrogenase n=2 Tax=Dictyoglomu... 59 2e-07 UniRef50_D2RBF2 Dihydroorotate dehydrogenase 1B n=21 Tax=Bifidob... 59 2e-07 UniRef50_Q3B2I1 Dihydroorotate oxidase B, catalytic subunit n=12... 59 3e-07 UniRef50_Q979G6 Dihydroorotate dehydrogenase n=4 Tax=Thermoplasm... 58 5e-07 UniRef50_C0QYH6 Dihydroorotate dehydrogenase n=2 Tax=Brachyspira... 57 8e-07 UniRef50_A4IM35 Dihydroorotate dehydrogenase n=348 Tax=Bacteria ... 57 8e-07 UniRef50_A3DM44 Dihydroorotate oxidase B, catalytic subunit n=1 ... 57 1e-06 UniRef50_Q01YA2 Dihydroorotate dehydrogenase n=5 Tax=Bacteria Re... 57 1e-06 UniRef50_A9BIU8 Dihydroorotate dehydrogenase family protein n=10... 56 2e-06 UniRef50_B1GYY3 Dihydroorotate dehydrogenase n=1 Tax=uncultured ... 56 2e-06 UniRef50_C8WHP0 Dihydroorotate dehydrogenase family protein n=3 ... 54 6e-06 UniRef50_C5R8W8 Dihydroorotate dehydrogenase B, catalytic subuni... 54 8e-06 UniRef50_C9KKE5 Dihydroorotate oxidase n=6 Tax=Bacteria RepID=C9... 54 8e-06 UniRef50_B8D3W9 Dihydroorotate dehydrogenase, PyrD n=1 Tax=Desul... 54 1e-05 UniRef50_C9M6H2 Dihydroorotate oxidase n=2 Tax=Synergistaceae Re... 53 1e-05 UniRef50_A1RZC9 Dihydroorotate oxidase B, catalytic subunit n=2 ... 53 2e-05 UniRef50_A6G037 Dihydroorotate dehydrogenase 1 n=1 Tax=Plesiocys... 52 3e-05 UniRef50_C5CHS6 Dihydroorotate dehydrogenase family protein n=1 ... 52 4e-05 UniRef50_P28272 Dihydroorotate dehydrogenase n=168 Tax=cellular ... 51 5e-05 UniRef50_A9D5Y9 Dihydroorotate dehydrogenase n=1 Tax=Shewanella ... 51 6e-05 UniRef50_B0PGY1 Putative uncharacterized protein n=1 Tax=Anaerot... 51 6e-05 UniRef50_A6L5H1 Dihydroorotate dehydrogenase n=7 Tax=Bacteroidal... 50 8e-05 UniRef50_A4VL83 Phosphoserine aminotransferase n=1 Tax=Pseudomon... 50 8e-05 UniRef50_D0JBI0 Dihydroorotate dehydrogenase n=2 Tax=Blattabacte... 50 1e-04 UniRef50_Q1AVZ1 Dihydroorotate oxidase B, catalytic subunit n=1 ... 49 2e-04 UniRef50_B8D2W4 Dihydroorotate dehydrogenase family protein n=1 ... 49 2e-04 UniRef50_Q1MQG1 Dihydroorotate dehydrogenase n=2 Tax=Deltaproteo... 49 2e-04 UniRef50_B0TGQ8 Dihydroorotate dehydrogenase n=32 Tax=Bacteria R... 49 3e-04 UniRef50_C4F860 Putative uncharacterized protein n=2 Tax=Collins... 48 5e-04 UniRef50_A4ECL7 Putative uncharacterized protein n=1 Tax=Collins... 48 5e-04 UniRef50_O08358 Dihydroorotate dehydrogenase n=12 Tax=Sulfolobac... 48 6e-04 UniRef50_Q9YFI6 Dihydroorotate dehydrogenase n=3 Tax=Desulfuroco... 47 9e-04 UniRef50_A0DS83 Chromosome undetermined scaffold_61, whole genom... 47 0.001 UniRef50_Q4DGY9 Dihydroorotate dehydrogenase, putative n=1 Tax=T... 47 0.001 UniRef50_D0U5Z4 Dihydroorotate dehydrogenase subfamily 1 family ... 47 0.001 UniRef50_C7M0V6 Dihydroorotate dehydrogenase family protein n=1 ... 47 0.001 UniRef50_A8MJK5 Dihydroorotate dehydrogenase family protein n=1 ... 47 0.001 UniRef50_A4FBL7 Dihydroorotate dehydrogenase n=1 Tax=Saccharopol... 46 0.002 UniRef50_A3CL85 NADH-dependent flavin oxidoreductase, putative n... 46 0.002 UniRef50_A9GKC4 Dihydropyrimidine dehydrogenase n=5 Tax=Bacteria... 46 0.002 UniRef50_A3U0T3 Probable dihydroorotate dehydrogenase, catalytic... 45 0.003 UniRef50_C4IB41 Dihydroorotate dehydrogenase family protein n=4 ... 45 0.003 UniRef50_O29513 Dihydroorotate dehydrogenase n=3 Tax=Archaeoglob... 45 0.003 UniRef50_A6CMG8 Putative uncharacterized protein n=1 Tax=Bacillu... 45 0.004 UniRef50_C1EGR6 Predicted protein n=8 Tax=Viridiplantae RepID=C1... 44 0.006 UniRef50_A3DL41 Dihydroorotate dehydrogenase family protein n=1 ... 44 0.006 UniRef50_B5YA20 Dihydroorotate dehydrogenase (Dihydroorotate oxi... 44 0.007 UniRef50_A0ADR6 Putative hihydroorotate dehydrogenase n=1 Tax=St... 44 0.008 UniRef50_C1TMB2 Dihydroorotate dehydrogenase family protein n=1 ... 44 0.011 UniRef50_B0EHW2 Dihydropyrimidine dehydrogenase, putative n=2 Ta... 43 0.014 UniRef50_Q12882 Dihydropyrimidine dehydrogenase [NADP+] n=94 Tax... 43 0.016 UniRef50_B0UTZ1 Dihydroorotate dehydrogenase n=5 Tax=Pasteurella... 43 0.018 UniRef50_C9XJU2 Dihydroorotate dehydrogenase, catalytic subunit ... 42 0.035 UniRef50_A5VL42 Dihydroorotate oxidase B, catalytic subunit n=14... 42 0.037 UniRef50_B9UIZ1 Putative dehydrogenase n=1 Tax=Streptomyces flav... 42 0.041 UniRef50_Q871G0 Related to dihydroorotate dehydrogenase a n=3 Ta... 41 0.066 >UniRef50_B1KDM8 Dihydroorotate dehydrogenase n=26 Tax=Gammaproteobacteria RepID=PYRD_SHEWM Length = 340 Score = 443 bits (1139), Expect = e-123, Method: Compositional matrix adjust. Identities = 213/333 (63%), Positives = 263/333 (78%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 M+Y +K +FQ+DPE+AH F L TP + QK+ PV MG+TF NP+GL Sbjct: 1 MFYKLAQKVMFQMDPEKAHHFALNSLMATANTPLDCFYAQKIAPSPVEFMGVTFPNPVGL 60 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAG+DKDGECID AMGFG IE+GTVTPRPQPGND PRLFRL A+G+INRMGFNN GV Sbjct: 61 AAGMDKDGECIDGFHAMGFGHIEVGTVTPRPQPGNDLPRLFRLKPAKGIINRMGFNNKGV 120 Query: 121 DNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPG 180 DNL+ N+K A ++G+NIGKNKDTPVEQGKDDYLICM+K+Y YA YIA+NISSPNTPG Sbjct: 121 DNLIANLKAAKSGALIGVNIGKNKDTPVEQGKDDYLICMDKVYEYAAYIAVNISSPNTPG 180 Query: 181 LRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNID 240 LR+LQYG+ LDDLL ++K KQ DL H KYVPIA+KIAPDLS+EE+ ++ADSL+++ D Sbjct: 181 LRSLQYGDLLDDLLGSLKAKQKDLAQKHGKYVPIALKIAPDLSDEEIQKIADSLIKNQFD 240 Query: 241 GVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDS 300 G IATNTTL R V G+ N ++TGGLSG+PL L ST +I++LS LNG++PIIGVGGI+S Sbjct: 241 GAIATNTTLSRDGVSGLMNANETGGLSGKPLNLLSTSVIKKLSSCLNGQIPIIGVGGINS 300 Query: 301 VIAAREKIAAGASLVQIYSGFIFKGPPLIKEIV 333 A +K+ AGAS+VQIYSGFI++GP LIK+I+ Sbjct: 301 AADAIDKLDAGASMVQIYSGFIYQGPKLIKDII 333 >UniRef50_P57443 Dihydroorotate dehydrogenase n=2 Tax=Proteobacteria RepID=PYRD_BUCAI Length = 337 Score = 389 bits (998), Expect = e-106, Method: Compositional matrix adjust. Identities = 195/337 (57%), Positives = 249/337 (73%), Gaps = 1/337 (0%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVP-AKPVNCMGLTFKNPLG 59 M+Y F+RK LF L+PE+AH T + L F+ + + +K + CMGL F N LG Sbjct: 1 MFYYFIRKLLFLLEPEKAHFLTLKYLNIKNIQFFDFFFYKTIILSKKIKCMGLIFDNKLG 60 Query: 60 LAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLG 119 AAG+DK+GE IDAL +GFG IE+GTVTP PQ GN KPR+FR+V EG+INRMGFNNLG Sbjct: 61 TAAGIDKNGEYIDALSKLGFGFIEVGTVTPLPQVGNPKPRMFRIVSMEGIINRMGFNNLG 120 Query: 120 VDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTP 179 +DNL+ N+KK+++ G++G+NIGKNK T +E DDYLIC+EKIY YAGYIAINISSPNT Sbjct: 121 IDNLIRNIKKSNFKGIIGVNIGKNKSTSLENSVDDYLICIEKIYCYAGYIAINISSPNTT 180 Query: 180 GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNI 239 LR LQYG LL IK KQ +L + KYVPIA+KI+PDLS +EL+ ++ L+R+ I Sbjct: 181 NLRNLQYGILFKKLLYKIKKKQKELHKKYLKYVPIAIKISPDLSIKELVDISKQLIRYKI 240 Query: 240 DGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGID 299 D VIATNTTLD S + G+KN + GGLSG PLQ KST I LS L ++PIIGVGGI+ Sbjct: 241 DAVIATNTTLDHSSLFGLKNSSEQGGLSGLPLQKKSTNTISILSKSLQKKIPIIGVGGIN 300 Query: 300 SVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 S+ +A+EKI +GA+L+QIYSG ++ GP LIK+I+ HI Sbjct: 301 SINSAKEKIESGATLIQIYSGLVYHGPKLIKKIINHI 337 >UniRef50_Q2Y5H8 Dihydroorotate dehydrogenase n=195 Tax=cellular organisms RepID=PYRD_NITMU Length = 348 Score = 365 bits (938), Expect = 1e-99, Method: Compositional matrix adjust. Identities = 186/333 (55%), Positives = 225/333 (67%), Gaps = 2/333 (0%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 M Y +R +F L+PE AH F + T + P + + MGLTF NP+GL Sbjct: 1 MLYSLLRPLVFALEPETAHGIAFNAME--TAHRLGLYRARPAPCRSRSIMGLTFPNPVGL 58 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAGLDK+GE IDAL A+GFG IEIGTVTPRPQPGN KPRLFRL A +INRMGFNN G+ Sbjct: 59 AAGLDKNGEHIDALAALGFGFIEIGTVTPRPQPGNPKPRLFRLPQANSIINRMGFNNNGI 118 Query: 121 DNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPG 180 + LV NVK Y G+LGINIGKN DTPVE+ DDYLIC+ K Y YA YI +NISSPNTP Sbjct: 119 EGLVANVKAMDYKGILGINIGKNFDTPVEKAVDDYLICLRKAYRYASYITVNISSPNTPN 178 Query: 181 LRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNID 240 LR LQ LD LL +K Q L H KY P+ VKIAPDL E+ +A L++H +D Sbjct: 179 LRQLQQATELDSLLGTLKLNQQRLADEHGKYTPLLVKIAPDLELPEIDSIAALLMKHRVD 238 Query: 241 GVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDS 300 GVIATNTTL R+ V+ + + + GGLSG PL ++T ++ RL L G LPIIGVGGI Sbjct: 239 GVIATNTTLSRAGVETLPHAREAGGLSGAPLAKRATSVVARLHHALQGALPIIGVGGIMD 298 Query: 301 VIAAREKIAAGASLVQIYSGFIFKGPPLIKEIV 333 A EKIAAGASL+Q+YSG +++GP L+ EI Sbjct: 299 AAGATEKIAAGASLIQVYSGLVYRGPHLVGEIA 331 >UniRef50_Q8D370 Dihydroorotate dehydrogenase n=46 Tax=Gammaproteobacteria RepID=PYRD_WIGBR Length = 337 Score = 337 bits (863), Expect = 4e-91, Method: Compositional matrix adjust. Identities = 175/334 (52%), Positives = 237/334 (70%), Gaps = 1/334 (0%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 M Y + L + D E + + ++ TP L++ K P ++CMGL FKN LGL Sbjct: 1 MIYKIINFILSKKDHEEKKDLLLKIMKFFNKTPLNFLIKNKFPNNNISCMGLNFKNILGL 60 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAGLDK+G+ I +GFG IE+GTVT +PQ G KPRLF + G+INRMGFNN G+ Sbjct: 61 AAGLDKNGDYIKLFSDIGFGFIELGTVTLKPQHGEKKPRLFCFPNVYGIINRMGFNNNGI 120 Query: 121 DNLVENVK-KAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTP 179 +NL+EN+K + + +LGINIGKNKDT +E+ KDDYLIC+ K Y Y+ YI+INISSPNT Sbjct: 121 ENLIENIKNEKNVKSILGINIGKNKDTLIEKAKDDYLICINKAYYYSDYISINISSPNTK 180 Query: 180 GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNI 239 LR LQ+GE DLL +IK +QN L +++KYVPI +KI+PD++ E+IQ++D L+ +NI Sbjct: 181 DLRKLQFGELFSDLLKSIKEEQNKLNKIYNKYVPILIKISPDINNSEIIQISDCLLSYNI 240 Query: 240 DGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGID 299 DGVIATNTT+++ ++ N + GGLSG PL ST II++LS EL G++PIIG GGI Sbjct: 241 DGVIATNTTVNKDIIMRCCNNCEKGGLSGAPLNENSTRIIKKLSKELKGKIPIIGSGGII 300 Query: 300 SVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIV 333 SV +A+EKI AGASL+QIYSG +F G +IK+++ Sbjct: 301 SVKSAKEKIKAGASLIQIYSGLVFFGLKIIKKLI 334 >UniRef50_B2UNA2 Dihydroorotate dehydrogenase n=8 Tax=Bacteria RepID=PYRD_AKKM8 Length = 348 Score = 334 bits (856), Expect = 3e-90, Method: Compositional matrix adjust. Identities = 165/332 (49%), Positives = 227/332 (68%), Gaps = 1/332 (0%) Query: 3 YPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAA 62 Y + LFQ++PE AH+ T LR LV +VP+ PV +G+ F N +GLAA Sbjct: 6 YSAAKSVLFQMNPETAHKVTLWGLRLAEKMRVLPLVMGEVPSDPVEILGMKFPNRVGLAA 65 Query: 63 GLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDN 122 G+DK+ + + A G GFG +E+GT+TPRPQPGN+KPRLFRL+ + +INRMGFNN G+ Sbjct: 66 GMDKEADTVSAFGQAGFGFVEVGTLTPRPQPGNEKPRLFRLIPQKAIINRMGFNNEGIAA 125 Query: 123 LVENVKKA-HYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGL 181 VEN++ A + GVLG+NIGKNK TP E DYL C+ + A YIAIN SSPNTPGL Sbjct: 126 GVENIRSATRFHGVLGVNIGKNKITPNEDAAQDYLTCLRAAWPVADYIAINFSSPNTPGL 185 Query: 182 RTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDG 241 R LQ E LL ++K++Q++L A ++VPI +K+APD+++E + +++ + +DG Sbjct: 186 RDLQAAEPAARLLASLKSEQSNLAAETGRHVPIFMKVAPDVTDEHIAELSRVFLDEGLDG 245 Query: 242 VIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSV 301 +IATNTTL R V+ ++ GGLSG PL +STE+I + EL GR+PIIGVGGI + Sbjct: 246 LIATNTTLSRVGVEANPRHEEAGGLSGAPLTERSTEVIGAFASELKGRIPIIGVGGIMNG 305 Query: 302 IAAREKIAAGASLVQIYSGFIFKGPPLIKEIV 333 + A KI AGASLVQ+Y+GF+++GP LI+E V Sbjct: 306 VDAVAKIKAGASLVQLYTGFVYRGPDLIRECV 337 >UniRef50_B6J754 Dihydroorotate dehydrogenase n=26 Tax=Proteobacteria RepID=PYRD_COXB1 Length = 347 Score = 332 bits (850), Expect = 1e-89, Method: Compositional matrix adjust. Identities = 164/336 (48%), Positives = 223/336 (66%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 M Y ++R LF+L+PE AH T L+ Q+ P KP G+ F NP+GL Sbjct: 1 MIYRYLRPWLFKLEPETAHALTLNCLKWFYCYWLINRRLQRFPQKPTVVFGIEFPNPVGL 60 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAGLDK+GE +D L +GFG IE+G VTP+PQPGN KPR+FRL A LINRMGFNNLGV Sbjct: 61 AAGLDKNGEYMDELLGLGFGFIEVGAVTPKPQPGNSKPRIFRLPQARALINRMGFNNLGV 120 Query: 121 DNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPG 180 D LVE +K+ G++G+NIGKN TP+E+ +DY C EK+Y+Y Y+ INISSPNTP Sbjct: 121 DYLVEQLKRRKVKGIVGVNIGKNLTTPLEKAHEDYQNCFEKLYSYVDYVTINISSPNTPE 180 Query: 181 LRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNID 240 LR LQ L DLLT +K Q L+ +HK VP+ +KIAPDL+ EE+ +A ++H I+ Sbjct: 181 LRQLQSERYLADLLTRLKEDQRRLEDQYHKRVPLFLKIAPDLTPEEIQTIATLALQHRIE 240 Query: 241 GVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDS 300 G++ATNT+ R + + N ++ GGLSG+PL + +++++L L +PI+ VGGI S Sbjct: 241 GIVATNTSCSRQGTEKLPNANEAGGLSGKPLFPMTLQVVKQLHSFLGDEIPIVAVGGIFS 300 Query: 301 VIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 A+ I AGA LVQ+Y+G I++GP L+K IV + Sbjct: 301 GENAQTLINAGARLVQLYTGLIYEGPELVKNIVEFL 336 >UniRef50_A1WJ81 Dihydroorotate dehydrogenase n=250 Tax=Bacteria RepID=PYRD_VEREI Length = 360 Score = 330 bits (847), Expect = 3e-89, Method: Compositional matrix adjust. Identities = 172/339 (50%), Positives = 218/339 (64%), Gaps = 5/339 (1%) Query: 3 YPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAA 62 Y R LF LD E AHE L R TP + + P+ GL F N +GLAA Sbjct: 6 YALTRPFLFGLDAEAAHELIIDLLARGQRTPLQWAWCNQTVDDPIELAGLRFPNRVGLAA 65 Query: 63 GLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDN 122 GLDK+ CIDALGAMGFG +E GTVTP+ QPGN +PR+FRL +A LINR+GFNN G+ Sbjct: 66 GLDKNARCIDALGAMGFGFVEAGTVTPQAQPGNPRPRMFRLPEARALINRLGFNNAGLQA 125 Query: 123 LVENVKKAHYDGV-----LGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPN 177 V N++++ LG+NIGKN TP+ Q DYL C+E +Y +A Y+A+NISSPN Sbjct: 126 FVHNLQQSRLRAAGSALRLGLNIGKNASTPMAQASSDYLACLEGVYPHADYVALNISSPN 185 Query: 178 TPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRH 237 T LRTLQ ALD LL AI ++ L A H + VP+ VKIAPDL E +L +A +L RH Sbjct: 186 TQNLRTLQGDAALDHLLGAIAERRATLAARHGRRVPVFVKIAPDLDEAQLSLMAATLQRH 245 Query: 238 NIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGG 297 IDGVIATNTT+DR++VQG ++ ++GGLSG P+ S ++I +L L PIIGVGG Sbjct: 246 GIDGVIATNTTIDRAVVQGQRHAQESGGLSGAPVLQASNQVIGQLRAALGKGFPIIGVGG 305 Query: 298 IDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 I S A KI AGA LVQIY+G I++GP L+ + I Sbjct: 306 IMSAEDAVSKIRAGADLVQIYTGLIYEGPALVVQAARAI 344 >UniRef50_C9YAQ9 Dihydroorotate dehydrogenase n=2 Tax=cellular organisms RepID=C9YAQ9_9BURK Length = 389 Score = 313 bits (802), Expect = 6e-84, Method: Compositional matrix adjust. Identities = 166/349 (47%), Positives = 214/349 (61%), Gaps = 15/349 (4%) Query: 3 YPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAA 62 Y R+ LF LDPE AH+ T L G P + PV GL F N +G+AA Sbjct: 36 YALARRVLFNLDPEVAHDITMAGLAASQGNPLKLAYCNSRVDDPVTIAGLQFPNRVGMAA 95 Query: 63 GLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDN 122 GLDK+ CID LGAMGFG +E+GTVTP QPGN KPR+FRL +A LINR+GFNN G+D Sbjct: 96 GLDKNARCIDGLGAMGFGFVEVGTVTPLAQPGNPKPRMFRLPEANALINRLGFNNHGLDA 155 Query: 123 LVENVKKAHYDG------VLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSP 176 + NV+++ +LG+NIGKN TP+E+ DDYLIC++ +Y +A YI +NISSP Sbjct: 156 FIANVQRSALRQSKNPSLLLGLNIGKNAATPIEKATDDYLICLDGVYPHADYITVNISSP 215 Query: 177 NTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVR 236 NT LR+LQ +ALD LL AI ++ L H + P+ +KIAPDL +++ +A +L R Sbjct: 216 NTKNLRSLQSDDALDALLGAIAERREQLAQKHGQRKPVFLKIAPDLEADQVAVIAATLKR 275 Query: 237 HNID---------GVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELN 287 + D GVI TNTTL R V+GM + ++ GGLSG P+ KS +I +L L Sbjct: 276 YGTDSSGKVNNAWGVIGTNTTLSRGAVKGMPHAEEMGGLSGAPVLEKSNAVIGQLRAALG 335 Query: 288 GRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 PIIGVGGI S A KI AGA VQIY+G I+ GP L+K I Sbjct: 336 KDFPIIGVGGIMSAADAVSKIKAGADAVQIYTGLIYSGPQLVKGAAVAI 384 >UniRef50_C0Z506 Dihydroorotate dehydrogenase n=8 Tax=Bacteria RepID=C0Z506_BREBN Length = 363 Score = 300 bits (768), Expect = 4e-80, Method: Compositional matrix adjust. Identities = 161/336 (47%), Positives = 216/336 (64%), Gaps = 6/336 (1%) Query: 3 YPFVRKALFQLDPERAHEFTFQQLRRITGT-PFEALVRQKVPAKPV----NCMGLTFKNP 57 Y +RK LFQ D E HE T LR + + P +++++ K G+TF NP Sbjct: 2 YQLIRKYLFQQDAEEIHEKTIGALRLVEDSAPGKSILKMIYQVKDQRLENKLWGMTFPNP 61 Query: 58 LGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNN 117 +GLAAG DK+ E ALGA+GFG +EIGT+TP+ QPGN KPRLFRL + + +INRMGFNN Sbjct: 62 VGLAAGFDKNAEVYHALGALGFGFVEIGTLTPQGQPGNPKPRLFRLPEHQAVINRMGFNN 121 Query: 118 LGVDNLVEN-VKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSP 176 G ++ V A+ D +GINIGKNK TP E+ DY CM+ +YAY Y INISSP Sbjct: 122 HGAYLASQHLVDYAYSDVPIGINIGKNKVTPNEEAAVDYSKCMDMLYAYGHYFVINISSP 181 Query: 177 NTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVR 236 NTP LR LQ E+L L+ A+K K +++ K PI +K+APD+S+E + V + V Sbjct: 182 NTPNLRDLQETESLRHLVRAVKEKATEMEGRSIKKKPILLKVAPDMSDEHMRDVVHAAVE 241 Query: 237 HNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVG 296 I G+IATNTTL R V G + ++ GGLSGRPL +ST ++ + E+ ++PIIGVG Sbjct: 242 EGISGIIATNTTLSREAVSGHRFAEEAGGLSGRPLTERSTAWVKEIYQEVGDKVPIIGVG 301 Query: 297 GIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 GI + A KI AGASLVQ+Y+G I++GP + K+I Sbjct: 302 GIYNGEDAYAKIRAGASLVQVYTGMIYQGPGIAKQI 337 >UniRef50_A1WTJ3 Dihydroorotate dehydrogenase n=1 Tax=Halorhodospira halophila SL1 RepID=PYRD_HALHL Length = 342 Score = 299 bits (766), Expect = 7e-80, Method: Compositional matrix adjust. Identities = 152/334 (45%), Positives = 218/334 (65%), Gaps = 7/334 (2%) Query: 3 YPFVRKALFQLDPERAHEFTFQQLR---RITGTPFEALVRQKVPAKPVNCMGLTFKNPLG 59 Y +R+ LF+L+PE+AH + Q R RI P VR +PA P MG+ F NP+G Sbjct: 2 YALIRQLLFRLEPEQAHRVSMQLARLGLRIAAVPG---VR-SLPAVPRRVMGIDFPNPVG 57 Query: 60 LAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLG 119 LAAG DKDGE +D L +GFG +E+GTVTPR QPGN +PR+FR+ + E LINRMGFNN G Sbjct: 58 LAAGFDKDGEYMDVLEQLGFGFLELGTVTPRAQPGNPQPRVFRIPEHEALINRMGFNNQG 117 Query: 120 VDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTP 179 + LV ++ + + GV+GINIGKN+DTP E+ +DY + +Y A Y+A+N+SSPNTP Sbjct: 118 AEPLVRRLEVSRHRGVVGINIGKNRDTPPERAVEDYAQALGMVYGVADYVAVNLSSPNTP 177 Query: 180 GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNI 239 GLR LQ+ AL +L+ ++ ++ L +H K VP+ VKIAPD EL D L+ + Sbjct: 178 GLRDLQHEGALRNLIDRLQTERKRLAELHDKRVPLVVKIAPDWEAGELDATLDILLERRV 237 Query: 240 DGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGID 299 DG++ATNTTL R+ V+ ++GGLSG PL+ ++ ++ +++ + R +I GGI Sbjct: 238 DGIVATNTTLGRTGVEQTPQARESGGLSGAPLREQAEWVLEQVAARRDRRTALIAAGGIM 297 Query: 300 SVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIV 333 S ++ GA LVQ+Y+G I++GP L++E V Sbjct: 298 SGEDVTRRLDLGADLVQLYTGMIYRGPGLVQEAV 331 >UniRef50_A5EV79 Dihydroorotate dehydrogenase n=3 Tax=Gammaproteobacteria RepID=PYRD_DICNV Length = 337 Score = 299 bits (765), Expect = 1e-79, Method: Compositional matrix adjust. Identities = 167/333 (50%), Positives = 212/333 (63%), Gaps = 8/333 (2%) Query: 3 YPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAA 62 YP +R LF L+PE AH T Q L R + + P++ +G TF N LGLAA Sbjct: 4 YPHLRPLLFCLNPEIAHNLTLQILSRAA-----VFIPRIKAGNPIHLLGHTFPNRLGLAA 58 Query: 63 GLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDN 122 GLDK+ I A +GFG IE+GT TPRPQ GN KPRLFRL + + +IN MGFNN GV Sbjct: 59 GLDKNAVAISAFDRLGFGFIEVGTATPRPQSGNPKPRLFRLPEHQAIINCMGFNNDGVVA 118 Query: 123 LVENVK--KAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPG 180 L + V K ++GINIGKNK TP E+ DDYLI M Y YA Y+AINISSPNT G Sbjct: 119 LCQQVAAVKKRTRALIGINIGKNKLTPNERAADDYLIAMSTAYPYADYLAINISSPNTVG 178 Query: 181 LRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNID 240 LR LQ+G AL +LL +K +++ L A++ K VP+ VKIAPD E+L ++ + ID Sbjct: 179 LRDLQHGAALCELLQRLKTERDKLSAVYEKTVPLLVKIAPDNEREQLDEMLSIIEDSGID 238 Query: 241 GVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDS 300 G+IATNTTLD++ V G + D+ GGLSG+PL KST+II + L LP+I GG+ S Sbjct: 239 GIIATNTTLDKTAVTGHRYADEQGGLSGKPLTEKSTKIIAHIRERLPD-LPLIASGGVMS 297 Query: 301 VIAAREKIAAGASLVQIYSGFIFKGPPLIKEIV 333 K+ AGA LVQIYSG I+ GP LIK+ + Sbjct: 298 ADDYYAKLEAGADLVQIYSGLIYHGPQLIKDCL 330 >UniRef50_A6H0L5 Dihydroorotate dehydrogenase n=28 Tax=Bacteria RepID=PYRD_FLAPJ Length = 350 Score = 285 bits (728), Expect = 2e-75, Method: Compositional matrix adjust. Identities = 169/348 (48%), Positives = 211/348 (60%), Gaps = 15/348 (4%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTP-----FEALVRQKVPAKPVNCMGLTFK 55 MY +R LF DPE+ H FTF +R I P F++L GL FK Sbjct: 1 MYKLIIRPILFCFDPEKVHYFTFSLIRTIAKIPGFTSIFKSLYEVNDKRLEREVFGLKFK 60 Query: 56 NPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGF 115 NP+GLAAG DKD + L GFG IEIGT+TP+ Q GN K RLFRL + +INRMGF Sbjct: 61 NPVGLAAGFDKDAKLYKELSNFGFGFIEIGTLTPKGQEGNPKKRLFRLQEDSAIINRMGF 120 Query: 116 NNLGVDNLVENVKKAHYDGVL-GINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINIS 174 NN GV VE +KK +GVL G NIGKNK TP E DY IC + +Y Y Y +N+S Sbjct: 121 NNGGVLEAVERLKKN--NGVLIGGNIGKNKLTPNENATSDYEICFDALYDYVDYFVVNVS 178 Query: 175 SPNTPGLRTLQYGEALDDLLTAIKNKQNDLQ------AMHHKYVPIAVKIAPDLSEEELI 228 SPNTP LR LQ E L LL ++NK + Q A PI +KIAPDL+ E+L+ Sbjct: 179 SPNTPNLRELQEKEPLTQLLNTLQNKNQNKQKQTRDGAQSSGAKPILLKIAPDLTNEQLL 238 Query: 229 QVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNG 288 + D + I G+IATNTT+ R +Q + N + GGLSG+PL +STE+IR LS + N Sbjct: 239 DIIDIVKTTKIAGIIATNTTISREGLQSI-NRIEMGGLSGKPLTNRSTEVIRFLSQKSNK 297 Query: 289 RLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 PIIGVGGI V A EK+ AGASL+Q+Y+GFI++GP L+K I I Sbjct: 298 AFPIIGVGGIHCVQDAIEKLEAGASLIQLYTGFIYEGPALVKAINKEI 345 >UniRef50_B4UG99 Dihydroorotate dehydrogenase n=23 Tax=Bacteria RepID=PYRD_ANASK Length = 364 Score = 281 bits (718), Expect = 3e-74, Method: Compositional matrix adjust. Identities = 154/335 (45%), Positives = 200/335 (59%), Gaps = 7/335 (2%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 M +P +R LFQLDPER H L R+ A +PA V CMGL F P+GL Sbjct: 1 MLWPALRSVLFQLDPERVHHLAHWALHRVPLAVARARRPAPIPALAVRCMGLDFDGPVGL 60 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAG DK + L +GF +EIGT+TPRPQPGND+PRLFRL + L+NRMGFNN G+ Sbjct: 61 AAGFDKGDVALPGLFGLGFSHVEIGTITPRPQPGNDRPRLFRLPEHRALLNRMGFNNEGM 120 Query: 121 DNLVENVKK---AHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPN 177 + + A G +GIN+GKNK TP E DYL C+E+++ YA Y+ +NISSPN Sbjct: 121 EACARRLAALPPAARLGPVGINVGKNKVTPNEDAAADYLACIERLHPYADYLVVNISSPN 180 Query: 178 TPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRH 237 TPGLR LQ +ALD LL A A P+ VK+APDLS E L + D + Sbjct: 181 TPGLRQLQERDALDRLLRACVRH----LAERAPGKPLLVKLAPDLSPEALDEAVDVAIAA 236 Query: 238 NIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGG 297 G++ATNTTL R+ V+ + GGLSG PL+ +T+++RR GR+PI+GVGG Sbjct: 237 GAAGIVATNTTLSRAGVERHPRAAEAGGLSGAPLERLATDVVRRCYARAAGRVPIVGVGG 296 Query: 298 IDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 + A KI AGA+LVQ Y+G I+ GP + + Sbjct: 297 VMDAEGAYAKIRAGATLVQAYTGLIYGGPGFVGRV 331 >UniRef50_A9CK85 Dihydroorotate dehydrogenase n=16 Tax=Alphaproteobacteria RepID=PYRD_AGRT5 Length = 363 Score = 272 bits (695), Expect = 2e-71, Method: Compositional matrix adjust. Identities = 152/337 (45%), Positives = 207/337 (61%), Gaps = 13/337 (3%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRR----ITGTPFEALVRQKVPAKPVNCMGLTFKN 56 ++ RK LF +DPE+AH + L+ P + ++Q V GL F N Sbjct: 4 LFSSVGRKGLFLIDPEKAHGLSVAALKSGFLPTCMVPHDPRLQQTV-------AGLVFPN 56 Query: 57 PLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFN 116 PLG+AAG DK+ E L +GFG EIGTVTPR Q GN KPR+FRLV+ EG+INR+GFN Sbjct: 57 PLGMAAGYDKNAEVPGPLLRLGFGFTEIGTVTPRAQSGNPKPRIFRLVEDEGVINRLGFN 116 Query: 117 NLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSP 176 N G +E + +A G++G+NIG NKD+ E DY+ +E YA A Y +NISSP Sbjct: 117 NEGHAAALERLTQARLRGIVGVNIGANKDS--EDRIADYVQGIEAFYAVASYFTVNISSP 174 Query: 177 NTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVR 236 NTPGLR LQ E+L LLTA+ ++ K +PI +KIAPDL+EE L VA+ + Sbjct: 175 NTPGLRDLQARESLAALLTAVLERRKTEAERLGKRIPIFLKIAPDLTEEGLDDVAEEALA 234 Query: 237 HNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVG 296 H++DG+I +NTTL R ++ + + GGLSG+PL ST ++ ++ + LPIIGVG Sbjct: 235 HDLDGLIVSNTTLSREGLRPGPHRGEAGGLSGKPLFELSTTVLAKMRRRVGANLPIIGVG 294 Query: 297 GIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIV 333 G+ S A EK+ AGA LVQ+YS +++GP L IV Sbjct: 295 GVSSAETALEKVRAGADLVQLYSCMVYEGPGLPSAIV 331 >UniRef50_C2QE06 Dihydroorotate dehydrogenase n=3 Tax=Bacillus cereus RepID=C2QE06_BACCE Length = 350 Score = 270 bits (690), Expect = 5e-71, Method: Compositional matrix adjust. Identities = 149/330 (45%), Positives = 204/330 (61%), Gaps = 7/330 (2%) Query: 13 LDPERAHEFTFQQLRRITGTPFEALVRQK---VPAKPVNC--MGLTFKNPLGLAAGLDKD 67 +DPE+AH T L+ + F + K + + C + + F NP+GLAAG DK Sbjct: 1 MDPEKAHTRTIHALKMMQSFSFARNMYNKNMRLNDSRLECKLLDIKFPNPIGLAAGFDKF 60 Query: 68 GECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENV 127 + L ++GFGS+E+G++TP+PQ GN KPRL+RL + LINRMGFN+ G+D +N Sbjct: 61 ADVYPGLASLGFGSVEVGSITPKPQSGNPKPRLYRLPEDTALINRMGFNSEGLDRAKQNF 120 Query: 128 KKAHYDGV-LGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQY 186 + LGIN+GKNKDTP DY +E +Y+Y Y INISSPNT GLR LQY Sbjct: 121 MTLPRPNIPLGINLGKNKDTPNSDATLDYQKGLETLYSYGDYFVINISSPNTEGLRDLQY 180 Query: 187 GEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATN 246 + L LL +I +K+N+L H++Y PI +KIAPDL+ E+L V + ID VIA N Sbjct: 181 VDTLKPLLASILDKRNELCKKHNQYRPIILKIAPDLTPEQLEGVISIIQEVKIDAVIAAN 240 Query: 247 TTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAARE 306 TT+ R+ + K Q GGLSG+PL +STEII ++ + G LPIIG GG+ + A E Sbjct: 241 TTISRTNLNS-KFQKQNGGLSGKPLNHRSTEIISKIYRQTQGNLPIIGSGGVFTGEDAYE 299 Query: 307 KIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 KI +GASL+QIY+ I++GP + K I I Sbjct: 300 KIKSGASLIQIYTSMIYRGPSVAKHINQEI 329 >UniRef50_B1ZSY3 Dihydroorotate oxidase n=3 Tax=Verrucomicrobia RepID=B1ZSY3_OPITP Length = 352 Score = 263 bits (671), Expect = 9e-69, Method: Compositional matrix adjust. Identities = 151/337 (44%), Positives = 207/337 (61%), Gaps = 20/337 (5%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITG-TPFEALV--RQKVPA---KPVNCMGLTFK 55 Y +R LF++DPE+AHE L + P L+ + ++PA +PV GL F Sbjct: 5 YERAIRPVLFRMDPEKAHELAVHGLTLLAKLQPVCRLLEWQHRLPADCRRPVRAFGLDFP 64 Query: 56 NPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGF 115 N +GLAAG DK+ AL A+GFG +EIGT+T QPGN+KPR+FR + +INRMGF Sbjct: 65 NAIGLAAGFDKNATAWPALAALGFGHVEIGTITALAQPGNEKPRVFRFPAEKAVINRMGF 124 Query: 116 NNLGVDNLVENVKKAHYDGV------LGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYI 169 NN G + + + AH GV LGIN+GK+K T ++Q DYL ++ +A YI Sbjct: 125 NNEGSEAIARRL--AHQPGVGQRRIPLGINLGKSKVTDLDQAAQDYLTSFGRLADHADYI 182 Query: 170 AINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQ 229 A+N+SSPNTPGLR LQ + +LL AI + VP+ +KIAPDL+ ++ Sbjct: 183 ALNVSSPNTPGLRQLQDEARVRELLGAISAANR----ARPRPVPLLLKIAPDLTFPQIDA 238 Query: 230 VADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGR 289 V +L+ DG+IATNTTL R +Q GGLSGRPL+ +STEII ++ G+ Sbjct: 239 VLAALMEFRFDGIIATNTTLARP--GPFAAANQAGGLSGRPLRRRSTEIINYIARATAGK 296 Query: 290 LPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGP 326 LPIIGVGGI+ +A EK+ AGA+L+QIY+G I++GP Sbjct: 297 LPIIGVGGIEDGASAAEKLDAGATLLQIYTGMIYRGP 333 >UniRef50_A9WDI1 Dihydroorotate dehydrogenase n=13 Tax=Bacteria RepID=PYRD_CHLAA Length = 363 Score = 258 bits (660), Expect = 2e-67, Method: Compositional matrix adjust. Identities = 150/347 (43%), Positives = 212/347 (61%), Gaps = 17/347 (4%) Query: 1 MYYPF-VRKALFQL---DPERAHEFTFQQLRRITGTP-------FEALVRQKVPAKPVNC 49 ++Y + +R LF+L D E AHE T L I+ + + +R + + V C Sbjct: 7 LFYRYGIRPILFRLGRGDAETAHERTLHILALISRSRLLCKTIGYLTTIRDQRLQRTV-C 65 Query: 50 MGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGL 109 G+ F NP+GLAAG+DKDG I A A+GFG +E+GTVT PQPGN +PRLFRL + E L Sbjct: 66 -GIPFPNPVGLAAGMDKDGVAIPAWAALGFGFVEVGTVTHHPQPGNPRPRLFRLPEQEAL 124 Query: 110 INRMGFNNLGVDNLVENVKKAHYDGV-LGINIGKNKDTPVEQGKDDYLICMEKIYAYAGY 168 INRMGFNN G +L + + + +G++IGK+K TP+EQ DDY +++ YA Y Sbjct: 125 INRMGFNNQGAASLARRLARLQPAPIPVGVSIGKSKITPLEQAIDDYRASFRQLFPYAAY 184 Query: 169 IAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHK-YVPIAVKIAPDLSEEEL 227 IAIN+SSPNTPGLR LQ + L LL A+++ +L + P+ VKIAPDLS+ + Sbjct: 185 IAINVSSPNTPGLRQLQDADQLRALLAALQHDNAELGRTDQRGPRPLLVKIAPDLSDTAI 244 Query: 228 IQVADSLVRHNIDGVIATNTTLDRSLVQGM--KNCDQTGGLSGRPLQLKSTEIIRRLSLE 285 +V H + G+IATNTT+ R + G+ + + GGLSGRPL ++ ++R ++ Sbjct: 245 EEVLTVCADHGVAGIIATNTTISREGLTGVDPRLAAEAGGLSGRPLIARALHVVRLIARL 304 Query: 286 LNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 RLPIIGVGGI + + AGASL+QIY+G ++ GP L + I Sbjct: 305 TGNRLPIIGVGGIHTPDDGLRMLEAGASLIQIYTGLVYYGPLLPRRI 351 >UniRef50_Q1V0W4 Dihydroorotate dehydrogenase n=5 Tax=Bacteria RepID=Q1V0W4_PELUB Length = 350 Score = 258 bits (658), Expect = 3e-67, Method: Compositional matrix adjust. Identities = 138/334 (41%), Positives = 207/334 (61%), Gaps = 12/334 (3%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 M+ F R +F++DPE AH + L+ + P A + P N G NP+G+ Sbjct: 1 MFSKF-RSLIFKIDPETAHNLAIKSLK-LNILPNIADQNKGDPIFKTNLFGKNIDNPIGM 58 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAG DK+ E + L +GFG +E+GTVTP Q GN KPR+FRLV+ + LINR+GFNNLG Sbjct: 59 AAGFDKNAEVYNPLFKLGFGFVEVGTVTPLEQYGNPKPRVFRLVEDQALINRLGFNNLGA 118 Query: 121 DNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPG 180 +N+ ++ + G+LGINIG NKD+ E +DYLI + Y A YI +NISSPNT Sbjct: 119 ENISHRIRSNSHKGLLGINIGPNKDS--EDRLNDYLIGLRNFYDIADYITVNISSPNTEN 176 Query: 181 LRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNID 240 LR D+LL AI+ ++ L++ +PI VKI+PD+S+E++ ++ L++H + Sbjct: 177 LRAFHDETKFDELLNAIEKEKVKLKSK----IPIVVKISPDISDEQIELISKILIKHKVS 232 Query: 241 GVIATNTTLDRSLVQGMKNC--DQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGI 298 +I +NTT + + N Q GGLSG+PL+ ++ ++I + L G++ IIGVGG+ Sbjct: 233 AIIVSNTTAKNR--EKLNNILKHQKGGLSGKPLEEEANKLISKFYKLLKGKIEIIGVGGV 290 Query: 299 DSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 DS +A +K AGAS VQ+Y+G +F+GP ++ +I Sbjct: 291 DSGESAYKKFQAGASYVQLYTGMVFQGPNIVGKI 324 >UniRef50_B6BWI2 Dihydroorotate oxidase n=1 Tax=beta proteobacterium KB13 RepID=B6BWI2_9PROT Length = 335 Score = 257 bits (656), Expect = 5e-67, Method: Compositional matrix adjust. Identities = 142/334 (42%), Positives = 206/334 (61%), Gaps = 6/334 (1%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQK--VPAKPVNCMGLTFKNPL 58 M Y R +F L PE +H F + L+ + F +L++ K KP+ GL FKN + Sbjct: 1 MLYRLFRSVIFLLPPEFSHHFILKILKIVN---FISLLKVKDIKNEKPIFIKGLNFKNKV 57 Query: 59 GLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNL 118 GLAAG DK+ E + +GFG +E+GTVTP+PQ GN KPR+FR + LIN GFNN+ Sbjct: 58 GLAAGFDKNAEHMQIFENLGFGFLELGTVTPKPQSGNKKPRIFRDPKNDALINSFGFNNV 117 Query: 119 GVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNT 178 G+ ++N+KK+ + V+GINIGKN TP E +DY+ CM + Y YA Y+ +NISSPNT Sbjct: 118 GIYKFIDNIKKSKINLVIGINIGKNALTPYEDSINDYIACMREAYVYADYLTVNISSPNT 177 Query: 179 PGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHN 238 LR L L + ++ ++N LQ K VPI +K++PD+ + ++ + D L+ +N Sbjct: 178 KNLRDLHNLSDLSIFIKSLMIEKNKLQKKLKKSVPIFLKLSPDIEKSKIKPIIDLLIANN 237 Query: 239 IDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGI 298 IDGVI TNTT+D+S + GG+SG PL++KS +++ + +L II VGGI Sbjct: 238 IDGVIVTNTTIDKSKISKPYQ-HLPGGVSGAPLKIKSEQMLSTVKKISKNKLLIISVGGI 296 Query: 299 DSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 + A ++I GA LVQIY+G I++GP L+ EI Sbjct: 297 MTADDALKRIRMGADLVQIYTGLIYQGPSLVNEI 330 >UniRef50_A7NLW9 Dihydroorotate dehydrogenase n=18 Tax=Bacteria RepID=PYRD_ROSCS Length = 367 Score = 256 bits (655), Expect = 6e-67, Method: Compositional matrix adjust. Identities = 143/343 (41%), Positives = 206/343 (60%), Gaps = 21/343 (6%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPF-----EALVRQKVPAKPVNCMGLTFK 55 M Y +R LF+LD ERAH+ R + P AL PA V GL F Sbjct: 1 MLYHLIRPLLFRLDAERAHDVVTAMFRATSRMPLLPRLISALYAWDDPALMVEWAGLRFA 60 Query: 56 NPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGF 115 +PLG+AAG DK + +DAL +GF +E+GTVTPRPQPGN PRLFRL + LINR+GF Sbjct: 61 SPLGVAAGFDKRADLVDALALLGFSHVEVGTVTPRPQPGNPGPRLFRLPEDMALINRLGF 120 Query: 116 NNLGVDNLVENVKKAHYDGVL-GINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINIS 174 N+ G+ + + ++ V+ G+NIGKN+DTP+E+ +DY + A Y+A+NIS Sbjct: 121 NSHGMVAVAKALRARRSRRVIVGVNIGKNRDTPLERAVEDYAATFVALAPLADYVAVNIS 180 Query: 175 SPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYV---PIAVKIAPDLSEEELIQVA 231 SPNTPGLR L AL++LL +L ++H + PIA+KI+PD + +++ +V Sbjct: 181 SPNTPGLRRLHERAALEELL-------RELMRLNHGLLYPRPIALKISPDETLDQIEEVV 233 Query: 232 DSLVRHNIDGVIATNTTLDRSLVQGMKN--CDQTGGLSGRPLQLKSTEIIRRLSLELNGR 289 + + IATNTTL R +G+++ ++TGGLSGRPL ++ ++IR + G Sbjct: 234 RAGCEAGVAAFIATNTTLAR---EGLRSRLANETGGLSGRPLAPRARQVIRAIYRLTRGT 290 Query: 290 LPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 P+IGVGG+ + A I AGA LVQ+Y+G ++ GP + +EI Sbjct: 291 PPVIGVGGVLTADDAYAHIRAGARLVQLYTGMVYAGPAIAREI 333 >UniRef50_D1SB76 Dihydroorotate dehydrogenase n=2 Tax=Micromonospora aurantiaca ATCC 27029 RepID=D1SB76_9ACTO Length = 377 Score = 256 bits (655), Expect = 6e-67, Method: Compositional matrix adjust. Identities = 149/347 (42%), Positives = 206/347 (59%), Gaps = 26/347 (7%) Query: 1 MYYPFVRKALFQL---DPERAHEFTFQQLRRITGTP--FEALVRQKVPAKPVNCMGLTFK 55 ++ VR LF L D E AHE+T +L ++ P AL + P G+ F Sbjct: 44 IFEKVVRPRLFSLAGGDAEGAHEWTLARLAAVSRQPAVLAALRAAYFRSAPRTVFGVRFP 103 Query: 56 NPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGF 115 NP+GLAAG+DK+G + A A+GFG +E+GTVT QPGN +PRLFRL D+E +INRMGF Sbjct: 104 NPVGLAAGMDKNGLALPAWPALGFGFVEVGTVTAHAQPGNPRPRLFRLRDSEAVINRMGF 163 Query: 116 NNLGVDNLVENVKKAHYD-GV-LGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINI 173 NN G + L + + GV LGI++GK+K TP+++ +DYL + + Y A+N+ Sbjct: 164 NNAGAEALADRLAALPRPLGVPLGISLGKSKVTPLDEAVEDYLASYRALKDHGDYFAVNV 223 Query: 174 SSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADS 233 SSPNTPGLR+LQ LD LL A+ ++ P+ VKIAPDL+E + ++ + Sbjct: 224 SSPNTPGLRSLQDRSHLDALLAALVGEK-----------PVLVKIAPDLTEPAVAELLEV 272 Query: 234 LVRHNIDGVIATNTTLDRSLVQGMKNCD-----QTGGLSGRPLQLKSTEIIRRLSLELNG 288 + GVIATNTTL R G+ D + GGLSGRPL ++ E++ + E G Sbjct: 273 CLDRGAAGVIATNTTLAR---DGLAPADRERAAEAGGLSGRPLTARAREMVAFVHRETGG 329 Query: 289 RLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTH 335 RLP+IGVGGI A AGASL+Q+Y+GFI++GP L + I T Sbjct: 330 RLPVIGVGGILHPDDATRMFDAGASLLQLYTGFIYRGPALTRAITTR 376 >UniRef50_A5UX75 Dihydroorotate dehydrogenase n=1 Tax=Roseiflexus sp. RS-1 RepID=PYRD_ROSS1 Length = 361 Score = 256 bits (654), Expect = 8e-67, Method: Compositional matrix adjust. Identities = 143/336 (42%), Positives = 203/336 (60%), Gaps = 11/336 (3%) Query: 3 YPFVRKALFQLDPERAHEFTFQQLRRITGTPF-----EALVRQKVPAKPVNCMGLTFKNP 57 Y +R LF+LD ERAH+ T + LR + P AL + P V+ GL F NP Sbjct: 5 YALIRPLLFRLDAERAHDLTAKALRVTSRAPLLPRLIRALYAWEDPLLAVDWSGLHFANP 64 Query: 58 LGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNN 117 +G+AAG DK + +D L +GFG IE+GTVTPRPQPGN +PRLFRL + LINR+GFN+ Sbjct: 65 VGVAAGFDKRADLVDGLALLGFGHIEVGTVTPRPQPGNPRPRLFRLPEDTALINRLGFNS 124 Query: 118 LGV-DNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSP 176 G+ + D ++G+NIGKN+DTP+E+ +DY+ + A Y+A+NISSP Sbjct: 125 PGMVAVARALRARRSRDVIVGVNIGKNRDTPLERAVEDYVATFVALAPIADYVAVNISSP 184 Query: 177 NTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVR 236 NTPGLR L AL+ LL + +A+ H PIA+K++PD + ++L V + Sbjct: 185 NTPGLRRLHERAALETLLHELTRLN---RALPHPR-PIALKVSPDETPDQLEAVVRAGCD 240 Query: 237 HNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVG 296 I IATNTTL R + + +TGGLSGRPL ++ ++I + +G P+IGVG Sbjct: 241 AGIAAFIATNTTLARDDLHS-RLAIETGGLSGRPLTQRARQVIGAIYRLTHGAPPVIGVG 299 Query: 297 GIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 GI + A + I AGA L+QIY+G ++ GP + ++I Sbjct: 300 GIATAEDAYQHIRAGARLIQIYTGMVYAGPAIARDI 335 >UniRef50_Q056I9 Dihydroorotate dehydrogenase n=6 Tax=Leptospira RepID=Q056I9_LEPBL Length = 384 Score = 255 bits (651), Expect = 2e-66, Method: Compositional matrix adjust. Identities = 143/333 (42%), Positives = 195/333 (58%), Gaps = 12/333 (3%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITG------TPFEALVRQKVPAKPVNCMGLTFK 55 Y F++ LDPE +HE + L I+ T E++ + G+ F+ Sbjct: 21 YSTFLKPFFLSLDPETSHELA-KNLLSISAKFPGILTLVESMTSYRSDRLKTRVAGIEFE 79 Query: 56 NPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGF 115 NPLG+ AG DK GE L MGFG IEIGT+T + QPGN KPR+FR + + LIN MGF Sbjct: 80 NPLGMGAGFDKTGELYPFLSRMGFGHIEIGTITGKSQPGNLKPRVFRYPEDQALINHMGF 139 Query: 116 NNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISS 175 NN G D+ + + GIN GK K E+ +DY+ ++K+ YA Y INISS Sbjct: 140 NNPGADSAERIIAPQKKRKIRGINAGKTKIISEEKAVEDYIYTLKKLSPYADYAVINISS 199 Query: 176 PNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLV 235 PNTPGLR Q + L+ IKN + +P+ VK APD+ ++L + +S + Sbjct: 200 PNTPGLRDFQKQKNFVSLIQGIKNGLG-----KNFIIPLFVKFAPDMETKDLEALLESSL 254 Query: 236 RHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGV 295 IDGV+ TNTT+D+S ++ N ++ GGLSG PL+ +STE +R L R+PIIGV Sbjct: 255 SLKIDGVVLTNTTIDKSSLKAYPNVEKEGGLSGVPLKNRSTEFVRVAYRILKRRIPIIGV 314 Query: 296 GGIDSVIAAREKIAAGASLVQIYSGFIFKGPPL 328 GGIDS AA EKI AGA L+QIY+G+I++GP L Sbjct: 315 GGIDSEKAALEKILAGADLIQIYTGYIYQGPFL 347 >UniRef50_D2S350 Dihydroorotate dehydrogenase n=2 Tax=Halobacteriaceae RepID=D2S350_9EURY Length = 356 Score = 252 bits (643), Expect = 2e-65, Method: Compositional matrix adjust. Identities = 138/330 (41%), Positives = 202/330 (61%), Gaps = 14/330 (4%) Query: 3 YPFVRKALFQLDPERAHEFTFQQLRRITGT-----PFEALVRQKVPAKPVNCMGLTFKNP 57 Y VR F+L E AH+ + LR T A R PA V+ TF NP Sbjct: 4 YSRVRPLAFKLPAETAHDLGKRTLRAAQSTWPTRRALAAAYRYDHPALEVDLFDSTFPNP 63 Query: 58 LGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNN 117 +G+AAG DK+ E AL A+GFG +EIGTVTP PQ GND+PRLFRL + EG+INRMGFN Sbjct: 64 VGIAAGFDKNAEVTHALEALGFGFVEIGTVTPYPQEGNDRPRLFRLREDEGMINRMGFNG 123 Query: 118 LGVDNLVENVKKAHYDGV-LGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSP 176 G++ + E +++ G LG+NIGK + + +DY +++ +A Y+ +N+S P Sbjct: 124 QGMETVKERLEEDGTPGFPLGVNIGKMNSSTEREAIEDYRRVFDRVSPFADYVVVNVSCP 183 Query: 177 NTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVR 236 NTP ++ EA + L AI L+A + VP+ VKI PD E+ ++ + D + Sbjct: 184 NTPD----EFNEASPEHLRAIFET---LEAENDGNVPMLVKIGPDEPEDAILDLVDIVQE 236 Query: 237 HNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVG 296 +DG++ATNT+ R ++ ++ GGLSG P++ +ST++IR ++ +G LPI+GVG Sbjct: 237 FGLDGIVATNTSTAREGLESPAR-EEWGGLSGAPIEDRSTDVIRTIAGHTDGELPIVGVG 295 Query: 297 GIDSVIAAREKIAAGASLVQIYSGFIFKGP 326 G+DS +A EKI AGASLVQ+Y+GF+++GP Sbjct: 296 GVDSAASAYEKIRAGASLVQLYTGFVYRGP 325 >UniRef50_D2PV93 Dihydroorotate dehydrogenase n=1 Tax=Kribbella flavida DSM 17836 RepID=D2PV93_9ACTO Length = 394 Score = 250 bits (639), Expect = 5e-65, Method: Compositional matrix adjust. Identities = 155/374 (41%), Positives = 208/374 (55%), Gaps = 48/374 (12%) Query: 2 YYPFVRKALFQL---DPERAHEFTFQQLRRITGTP--FEALVRQ--KVPAKPVNCM-GLT 53 Y VR L++L D E AHE T LRR+T P AL R +PA + G+ Sbjct: 5 YRTLVRPVLYRLGRGDAEVAHEQTLHGLRRLTRVPGAVSALSRSYGALPAGLARTVFGVR 64 Query: 54 FKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRM 113 F +P+GLAAG+DK+G + A A+GFG +E+GTVT PQPGN+KPRLFRLV++E +INRM Sbjct: 65 FPSPVGLAAGMDKNGIALPAWRALGFGFVEVGTVTAHPQPGNEKPRLFRLVESEAVINRM 124 Query: 114 GFNNLGVDNLVENVKKAHYDGV-LGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAIN 172 GFNNLG L + + G LGI+IGK+K TP+E +DY+ + ++Y + Y A+N Sbjct: 125 GFNNLGSAALADRLAAYGPLGYPLGISIGKSKVTPIEDAVEDYVTSLRRLYRFGDYFAVN 184 Query: 173 ISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYV-------------------- 212 +SSPNTPGLR+LQ L +LL A+ + L Sbjct: 185 VSSPNTPGLRSLQDAGHLRELLAALHTEAAALAGSGSGSGFGATSGSGAESRSGAESGSG 244 Query: 213 -----------PIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCD 261 PI VKIAPDL+E + ++ + G+IATNTT+ R + + D Sbjct: 245 AESGSGSGAVKPILVKIAPDLTEAAIDELLGVCTDAGVAGIIATNTTIGR---EALAPAD 301 Query: 262 Q-----TGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQ 316 Q GGLSGRPL S + + + E G LPIIGVGGI A I AGASLVQ Sbjct: 302 QALAAEAGGLSGRPLTEISAKTVAHIHAETGGALPIIGVGGILDPSDAARLIDAGASLVQ 361 Query: 317 IYSGFIFKGPPLIK 330 +Y+G I++GP L++ Sbjct: 362 LYTGLIYRGPGLVR 375 >UniRef50_Q3IU78 Dihydroorotate dehydrogenase n=13 Tax=cellular organisms RepID=PYRD_NATPD Length = 350 Score = 249 bits (636), Expect = 1e-64, Method: Compositional matrix adjust. Identities = 140/337 (41%), Positives = 200/337 (59%), Gaps = 21/337 (6%) Query: 3 YPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKV----PAKPVNCMGLTFKNPL 58 Y ++ ALFQLD E AH + L I GTP E +V P V+ G TF NP+ Sbjct: 4 YQLLKPALFQLDAETAHGLGHRVLDGIQGTPLERIVADYCTVVDPRLRVDAFGQTFPNPV 63 Query: 59 GLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNL 118 G+AAG DK+ E DALGA+GFG +E+G VT PQ GN +PR+FRL + LINRMGFNN Sbjct: 64 GVAAGFDKNAEIPDALGALGFGHVEVGGVTAEPQAGNPRPRMFRLAEDRALINRMGFNND 123 Query: 119 GVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNT 178 G D + E + +G+NIGK+K + + DY E++ Y +N+SSPNT Sbjct: 124 GADIVGERLAATDCRVPVGVNIGKSKSAANDDAEADYQYTYERVADGGDYFVVNVSSPNT 183 Query: 179 PGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSE---EELIQVADSLV 235 PGLR LQ + L+ +L +++ P+ VK++PDL++ E+ I+V + L Sbjct: 184 PGLRELQSRDRLESILGTLQDD---------GASPLLVKLSPDLTDAAIEDAIEVVEDL- 233 Query: 236 RHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGV 295 +DG+IATNTT R D+ GGLSG P+ +ST+I+R ++ + PI+GV Sbjct: 234 --GLDGIIATNTTTKRPASLHSDAADEEGGLSGAPITDESTDIVRFIAKRTD--KPIVGV 289 Query: 296 GGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 GGID +A EKI GAS+VQ+Y+G +++GP + ++I Sbjct: 290 GGIDDAESAYEKIRNGASVVQLYTGLVYEGPTIARDI 326 >UniRef50_B6R4R9 Dihydroorotate oxidase n=1 Tax=Pseudovibrio sp. JE062 RepID=B6R4R9_9RHOB Length = 367 Score = 248 bits (634), Expect = 1e-64, Method: Compositional matrix adjust. Identities = 140/331 (42%), Positives = 207/331 (62%), Gaps = 7/331 (2%) Query: 8 KALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKD 67 +AL LDPE +H T + L F + + + K LTFKNP+G+AAG DK+ Sbjct: 13 RALHCLDPETSHNATIKMLASGLAPTFGQVENKALEYK---LGDLTFKNPVGMAAGFDKN 69 Query: 68 GECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENV 127 E I L +GFG +E+GTVTP PQ GN KPR FRL +INR GFNN G D + E + Sbjct: 70 AEAITPLMKLGFGHVEVGTVTPLPQEGNPKPRNFRLSADRAVINRYGFNNDGHDVVYERI 129 Query: 128 KKA-HYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQY 186 +KA GVLGIN+G NK + E DY++ +++ A Y+ NISSPNTPGLR LQ Sbjct: 130 RKAGRTPGVLGINVGANKLS--EDRVADYVLGVKRFAELADYLTANISSPNTPGLRDLQE 187 Query: 187 GEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATN 246 +AL LL+AI N +++ + + VP+ +KIAPD++EE L ++A+ ++ + +DG+I +N Sbjct: 188 KDALAHLLSAIVNARDEQEDRLGRKVPVMLKIAPDVTEEALKEIAEVVMTNKVDGMIVSN 247 Query: 247 TTLDR-SLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAR 305 TT+ R S ++ + ++ GGLSG PL ++T + + + LP+ GVGG+D+ A Sbjct: 248 TTIARPSTLKDQQQAEEAGGLSGAPLFERATIALAKTRRAVGPDLPLFGVGGVDTPEKAA 307 Query: 306 EKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 KI AGA+ +Q+YSG +++G L+K+I H+ Sbjct: 308 AKIFAGANQIQLYSGMVYEGQTLVKKINKHL 338 >UniRef50_Q2RX27 Dihydroorotate dehydrogenase n=14 Tax=cellular organisms RepID=PYRD_RHORT Length = 367 Score = 247 bits (631), Expect = 4e-64, Method: Compositional matrix adjust. Identities = 144/332 (43%), Positives = 194/332 (58%), Gaps = 9/332 (2%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLR-RITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 +Y + LDPERAH + L + G A P + G F NPLGL Sbjct: 4 WYRLAWPLICGLDPERAHHLAIRALALGLAGHDRAA----DDPVLACSLWGRRFANPLGL 59 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAG DK+GE DAL +GFG +E+GTVTPRPQ GN +PRLFRL +INRMGFNN G+ Sbjct: 60 AAGFDKNGEVADALFDLGFGFVEVGTVTPRPQAGNPRPRLFRLTQDRAVINRMGFNNQGM 119 Query: 121 DNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPG 180 + + +A GVLGIN+GKNK T E DY + K+ A Y+ IN+SSPNTPG Sbjct: 120 EAMAARFVRARPRGVLGINLGKNKTT--EDAAGDYEAGIAKLAPLADYLVINVSSPNTPG 177 Query: 181 LRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNID 240 LR LQ E L L+ + + A P+ +K+APDL++E++ +A+ + +D Sbjct: 178 LRALQGREPLSLLIARARAALD--AACPGLRPPLLLKVAPDLTDEDMADIAEVALGGGLD 235 Query: 241 GVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDS 300 G+I TNTT+ R + +TGGLSG PL+ ++ ++I RL G LP+IGVGGI Sbjct: 236 GLICTNTTIARPKSLVSDHAGETGGLSGLPLRYRARQVIARLYGLTKGALPLIGVGGIGD 295 Query: 301 VIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 A +I AGASL+QIYS +++GP L+ I Sbjct: 296 GAEAYARIRAGASLIQIYSALVYEGPGLVGRI 327 >UniRef50_A5U4G5 Dihydroorotate dehydrogenase n=31 Tax=Corynebacterineae RepID=PYRD_MYCTA Length = 357 Score = 246 bits (629), Expect = 7e-64, Method: Compositional matrix adjust. Identities = 147/337 (43%), Positives = 201/337 (59%), Gaps = 17/337 (5%) Query: 3 YPFVRKALFQLDPERAHEFTFQQLRRITG-TPFEALVRQKV-PAKPV---NCMGLTFKNP 57 YP VR+ LF + PE AH+ F LR + P L+R+ + P PV G+ F P Sbjct: 2 YPLVRRLLFLIPPEHAHKLVFAVLRGVAAVAPVRRLLRRLLGPTDPVLASTVFGVRFPAP 61 Query: 58 LGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNN 117 LGLAAG DKDG + + GAMGFG EIGTVT PQPGN PRLFRL D L+NRMGFNN Sbjct: 62 LGLAAGFDKDGTALSSWGAMGFGYAEIGTVTAHPQPGNPAPRLFRLADDRALLNRMGFNN 121 Query: 118 LGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPN 177 G L + + + +G+NIGK K TP +DY + A Y+ +N+SSPN Sbjct: 122 HGARALAIRLARHRPEIPIGVNIGKTKKTPAGDAVNDYRASARMVGPLASYLVVNVSSPN 181 Query: 178 TPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRH 237 TPGLR LQ E+L +L+A++ + + P+ VKIAPDLS+ +L +AD V Sbjct: 182 TPGLRDLQAVESLRPILSAVRAETS---------TPVLVKIAPDLSDSDLDDIADLAVEL 232 Query: 238 NIDGVIATNTTLDRSLVQGMKNCDQ--TGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGV 295 ++ G++ATNTT+ R + D+ GG+SG PL ++ +++RRL + RL +I V Sbjct: 233 DLAGIVATNTTVSRDGLT-TPGVDRLGPGGISGPPLAQRAVQVLRRLYDRVGDRLALISV 291 Query: 296 GGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 GGI++ A E+I AGASL+Q Y+GFI+ G K+I Sbjct: 292 GGIETADDAWERITAGASLLQGYTGFIYGGERWAKDI 328 >UniRef50_Q47RF2 Dihydroorotate dehydrogenase n=52 Tax=Bacteria RepID=PYRD_THEFY Length = 377 Score = 243 bits (621), Expect = 5e-63, Method: Compositional matrix adjust. Identities = 144/348 (41%), Positives = 201/348 (57%), Gaps = 22/348 (6%) Query: 1 MYYPFVRKALFQ-LDPERAHEFTFQQLRRITGTPFEALVRQKV--PAKP---VNCMGLTF 54 M Y F+ L + +D ERAH +F LR + P + ++V P +P V G F Sbjct: 1 MLYQFIFHTLLRRVDAERAHRVSFAGLRALAAVPGTTRLMRRVLGPREPELRVRVFGREF 60 Query: 55 KNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMG 114 PLGLAAG DK+ + AL A+GF +EIGTVT +PQPGN +PRLFRLV ++NRMG Sbjct: 61 PGPLGLAAGFDKNARGVAALTALGFSHVEIGTVTGQPQPGNPRPRLFRLVADRAIVNRMG 120 Query: 115 FNNLGVDNLVE----NVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIA 170 FNN G + E + + D ++G+NIGK K P DY+ + A Y+ Sbjct: 121 FNNEGSQAVSERLRAHRARRARDLIVGVNIGKTKVVPDSDAVADYVTSARRFADLADYLV 180 Query: 171 INISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQV 230 +N+SSPNTPGLR LQ E L LL+A++ L +P+ VKIAPDL++E++ V Sbjct: 181 VNVSSPNTPGLRDLQATERLRPLLSAVRRT---LDEAGRPDLPLLVKIAPDLADEDIDAV 237 Query: 231 ADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQ------TGGLSGRPLQLKSTEIIRRLSL 284 AD V +DG+IATNTT+ R G+ + GGLSG PL+ ++ +++RRL Sbjct: 238 ADLAVELGLDGIIATNTTVSR---DGLATDPEEVAALGAGGLSGAPLKERALQVLRRLRA 294 Query: 285 ELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 + RL +I VGGI++ A +I AGA+LVQ Y+G I+ GP + I Sbjct: 295 RVGDRLVLIAVGGIETPEDAWARIRAGATLVQGYTGLIYGGPLWPRRI 342 >UniRef50_Q7PYN9 AGAP002037-PA (Fragment) n=10 Tax=cellular organisms RepID=Q7PYN9_ANOGA Length = 404 Score = 243 bits (619), Expect = 9e-63, Method: Compositional matrix adjust. Identities = 142/342 (41%), Positives = 206/342 (60%), Gaps = 24/342 (7%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLR-RITGTPFEALVRQKVPAKPVNCMGLTFKNPLG 59 ++ P VR + PE AH+ ++ ++ P++ R + +G+ F NP+G Sbjct: 48 VFMPIVR----LIPPETAHDLAVLGVKWKLFRPPYQDTDRLRT-----RLLGMAFSNPIG 98 Query: 60 LAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLG 119 +AAG DK GE + L +GFG +EIG+VTP PQPGN +PR+FRL + + ++NR GFN+ G Sbjct: 99 IAAGFDKHGEAVQGLQLIGFGFVEIGSVTPEPQPGNARPRIFRLNEDKAIVNRYGFNSEG 158 Query: 120 VDNLVENVKKAHYDG------VLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINI 173 D + E +++ LGIN+GKNK + DY+ +++ A Y+ IN+ Sbjct: 159 HDVVYERLRECREQQPPDQRVALGINLGKNKLS--LDAIADYVQGVKRFGTLADYLVINV 216 Query: 174 SSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADS 233 SSPNTPGLRT+Q L LLT + + L A + PI +K+APDLSEE+L ++ D Sbjct: 217 SSPNTPGLRTMQSKSTLQTLLTEVLKARASLPANEQR--PILLKLAPDLSEEDLREIVD- 273 Query: 234 LVRHN---IDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRL 290 +VR +DG+I +NTT+DR N Q GGLSG PL+ +ST +I R+ G++ Sbjct: 274 VVRAKACAVDGLIVSNTTIDRPATLRSVNAGQLGGLSGPPLKHRSTAMIARVYKLTEGKI 333 Query: 291 PIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 PIIGVGGI + A EKI AGAS VQ+Y+ FIF GPP++ +I Sbjct: 334 PIIGVGGIFTGEDAFEKIEAGASAVQLYTSFIFHGPPVVPKI 375 >UniRef50_B0W4C3 Dihydroorotate dehydrogenase, mitochondrial n=2 Tax=Culicini RepID=B0W4C3_CULQU Length = 397 Score = 242 bits (617), Expect = 1e-62, Method: Compositional matrix adjust. Identities = 148/343 (43%), Positives = 198/343 (57%), Gaps = 28/343 (8%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPF----EALVRQKVPAKPVNCMGLTFKN 56 ++ P VR + PE AH L+ P E L Q + T +N Sbjct: 44 IFMPMVR----MVPPELAHRLAVLGLKMEVVRPSFQDPEVLRTQ--------LLNKTLEN 91 Query: 57 PLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFN 116 P+G+AAG DK GE + L +GFG +EIG+VTP PQPGN KPR+FRL + + ++NR GFN Sbjct: 92 PVGIAAGFDKHGEAVKGLERLGFGFVEIGSVTPEPQPGNPKPRVFRLNEDKAIVNRYGFN 151 Query: 117 NLGVDNLVENVKKAHYDG----VLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAIN 172 + G + + E +KK DG LGIN+G+NK + E +DY+ + K A Y+ +N Sbjct: 152 SEGHEVVFERIKKLRQDGDLKVTLGINLGRNKKS--EDNIEDYVQGIRKFSVLADYLVVN 209 Query: 173 ISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSE---EELIQ 229 ISSPNTPGLRT+Q L LLT I +N L + PI VKIAPDLS+ +E+I Sbjct: 210 ISSPNTPGLRTMQNKSTLQSLLTEIVKARNALPPNEQR--PILVKIAPDLSDGCVQEIIA 267 Query: 230 VADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGR 289 V IDG+I +NTT+DR N Q GGLSG PL KST+++ ++ GR Sbjct: 268 VIQK-KECAIDGLIVSNTTIDRPSELKSINAGQLGGLSGAPLSSKSTQLVAKVYKWTGGR 326 Query: 290 LPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 +PIIGVGGI S A EKI AGAS VQ+Y+ I+ GPP++ + Sbjct: 327 VPIIGVGGIFSGRDAYEKILAGASAVQLYTALIYHGPPIVARV 369 >UniRef50_P74782 Dihydroorotate dehydrogenase n=24 Tax=Bacteria RepID=PYRD_SYNY3 Length = 381 Score = 241 bits (616), Expect = 2e-62, Method: Compositional matrix adjust. Identities = 137/352 (38%), Positives = 204/352 (57%), Gaps = 29/352 (8%) Query: 3 YPFVRKALFQLDPERAHEFTFQQLRRIT-------GTPFEALVRQKVPAKP---VNCMGL 52 YP + ++ + DPER H+ Q L+++ E L + A P C GL Sbjct: 9 YPLIL-SVTKSDPERGHQRLIQTLKKVDTMHRNGFAVAMEQLEQAFTHADPRLQQTCWGL 67 Query: 53 TFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINR 112 F N LGL+AG DK+GE A+GFG E+G VT QPGND+PRLFRL + ++NR Sbjct: 68 NFPNVLGLSAGCDKEGEAAAVWPALGFGFAELGAVTKYAQPGNDRPRLFRLPQDQAVLNR 127 Query: 113 MGFNNLGVDNLVENVKKA--HYDGV--LGINIGKNKDTPVEQGKDDYLICMEKIYAYAGY 168 +G NN G + +K +Y +GIN+ K+K TP++Q +DY+ + + A Y Sbjct: 128 LGANNEGAVAMAAKLKHTWDYYPRTIPIGINLCKSKITPLDQAVEDYVFSFQTLAPVADY 187 Query: 169 IAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELI 228 +N+SSPNTPGLR+LQ + L + LQ+ +H P+ VKI+PDLS E + Sbjct: 188 FVVNVSSPNTPGLRSLQESDELPRIFAG-------LQSANHWQKPLLVKISPDLSWEAIA 240 Query: 229 QVADSLVRHNIDGVIATNTTLDRSLVQ-------GMKNCDQTGGLSGRPLQLKSTEIIRR 281 + D + HN+ G++ATNT+ RS ++ G + GGLSG+P++ ++TE+IR Sbjct: 241 VIIDLVKEHNLSGIVATNTSTRRSGLKTKILPQTGQPIEQEAGGLSGQPIRDRATEVIRY 300 Query: 282 LSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIV 333 + + G +PIIGVGGI + A EKI AGAS +QIY+G+I+ GP ++ +I+ Sbjct: 301 IYQQTGGTIPIIGVGGIFTAEDAWEKIQAGASFLQIYTGWIYGGPWVVSDIL 352 >UniRef50_Q827Q6 Dihydroorotate dehydrogenase n=12 Tax=Actinomycetales RepID=PYRD_STRAW Length = 368 Score = 241 bits (615), Expect = 3e-62, Method: Compositional matrix adjust. Identities = 144/337 (42%), Positives = 204/337 (60%), Gaps = 14/337 (4%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPF-----EALVRQKVPAKPVNCMGLTFK 55 MY F R ++DPE+AH F+ +R P A + + GL Sbjct: 1 MYKLFFRLVFKRMDPEQAHYLAFRWIRLAARIPVLRTFVAAALAPRFKELRTEAFGLRMH 60 Query: 56 NPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGF 115 P GLAAG DK+ +D + +GF +EIGTVT PQPGN K RLFRLV LINRMGF Sbjct: 61 GPFGLAAGFDKNAVAVDGMSMLGFDHVEIGTVTGEPQPGNPKKRLFRLVPDRALINRMGF 120 Query: 116 NNLG--VDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINI 173 NN G ++A + V+G+NIGK K P E+ DDY+ E++ +A Y+ +N+ Sbjct: 121 NNEGSAAVAARLAAREAVFRTVVGVNIGKTKVVPEEEAADDYVKSTERLARHADYLVVNV 180 Query: 174 SSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADS 233 SSPNTPGLR LQ EAL LL+A++ + + + + VP+ VKIAPDL+++++ VAD Sbjct: 181 SSPNTPGLRNLQATEALRPLLSAVREAAD--RTVTERRVPLLVKIAPDLADDDIDAVADL 238 Query: 234 LVRHNIDGVIATNTTLDRSLVQGMKN----CDQTGGLSGRPLQLKSTEIIRRLSLELNGR 289 V +DG+IATNTT+ R + G+K+ +TGGLSG PL+ +S E++ RL + R Sbjct: 239 AVELGLDGIIATNTTIAREGL-GLKSEPTLVKETGGLSGAPLKARSLEVLSRLYARVGDR 297 Query: 290 LPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGP 326 + ++GVGGI++ A ++I AGA+LVQ YS FI++GP Sbjct: 298 ITLVGVGGIENAEDAWQRILAGATLVQGYSAFIYEGP 334 >UniRef50_Q30R79 Dihydroorotate dehydrogenase n=10 Tax=Campylobacterales RepID=PYRD_SULDN Length = 352 Score = 240 bits (612), Expect = 6e-62, Method: Compositional matrix adjust. Identities = 145/343 (42%), Positives = 202/343 (58%), Gaps = 32/343 (9%) Query: 3 YPFVRKALFQLDPERAHEFTFQQLR-----RITGTPF-------EALVRQKVPAKPVNCM 50 Y ++ LF+L+PE AH LR ++ PF ++++Q++ Sbjct: 4 YQSIKPWLFKLEPEDAHMLAEAALRIPNVCQVAFNPFLESHFITNSILKQEL-------F 56 Query: 51 GLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLI 110 G TF NP+GL AG DK+ I A+ +GFG EIGT+TP+ Q GN KPR+FR ++ + + Sbjct: 57 GRTFFNPIGLGAGFDKNATMIRAMQILGFGFTEIGTITPKAQAGNPKPRMFRHIEEQSIQ 116 Query: 111 NRMGFNNLGVDNLVENVKKAH-YDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYI 169 N MGFNN G+ + + +KK + +GINIGKNK TP Q +DY ++ ++ Y+ Sbjct: 117 NAMGFNNEGLLSAQKRLKKRFPFTTPIGINIGKNKLTPDTQAINDYTTLIKALHELGDYL 176 Query: 170 AINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQ 229 INISSPNTPGLR LQ E + L + +A+ K PI +KIAPD+S+E+ + Sbjct: 177 VINISSPNTPGLRDLQNEEFITKLF-------EESKAITSK--PILLKIAPDMSKEDAVA 227 Query: 230 VADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGR 289 + V DG+IATNTT+D SLV+ K+ GGLSG L+ KS EI ++ EL G+ Sbjct: 228 LTKLAVLKGADGIIATNTTVDYSLVKEPKSI---GGLSGAVLKEKSFEIFEAVAKELYGK 284 Query: 290 LPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 +I VGGI S +I AGASLVQIYSG I++GP LIK I Sbjct: 285 TTLISVGGISSAKEVYRRIKAGASLVQIYSGLIYEGPDLIKNI 327 >UniRef50_A5EA61 Dihydroorotate dehydrogenase n=122 Tax=cellular organisms RepID=PYRD_BRASB Length = 364 Score = 240 bits (612), Expect = 6e-62, Method: Compositional matrix adjust. Identities = 143/329 (43%), Positives = 197/329 (59%), Gaps = 17/329 (5%) Query: 10 LFQLDPERAHEFTFQQLR---RITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAAGLDK 66 L LD E AH Q L+ I P +A + V GL F NP+G+AAG DK Sbjct: 13 LRWLDAEDAHRLAIQGLKLLPAIKPRPDDAKL-------AVRAFGLNFPNPVGMAAGFDK 65 Query: 67 DGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVEN 126 + E DAL +GFG +EIG+VTPRPQ GN +PRLFRL E ++NRMGFNN G + ++ Sbjct: 66 NAEVPDALLRLGFGFVEIGSVTPRPQSGNPRPRLFRLERDEAVVNRMGFNNDGAEIVLRR 125 Query: 127 VK-KAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQ 185 + +A+ G++G+N+G NKD+ DY+ +E A Y +NISSPNTPGLR LQ Sbjct: 126 LAGRANQGGIVGVNVGANKDSADRVA--DYVRLIETFAPVASYFTVNISSPNTPGLRNLQ 183 Query: 186 YGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIAT 245 L++LL+ + ++ ++ P+ +KIAPDLS EL V +DG+I + Sbjct: 184 QAAQLNELLSKVLEARDRVRRKAGD-TPVLLKIAPDLSLAELDDVVHVARSRGVDGMIVS 242 Query: 246 NTTLDR--SLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIA 303 NTTL R SL + ++ +Q GGLSGRPL ST ++ + + G P+IGVGGIDS A Sbjct: 243 NTTLARPNSLREQLRAKEQ-GGLSGRPLFRLSTRMVAETFVRVEGAFPLIGVGGIDSGGA 301 Query: 304 AREKIAAGASLVQIYSGFIFKGPPLIKEI 332 A KI AGASL+Q+YS ++KG L++ I Sbjct: 302 ALTKIRAGASLIQLYSSLVYKGLGLVESI 330 >UniRef50_C6NV76 Dihydroorotate dehydrogenase n=1 Tax=Acidithiobacillus caldus ATCC 51756 RepID=C6NV76_9GAMM Length = 367 Score = 239 bits (611), Expect = 7e-62, Method: Compositional matrix adjust. Identities = 139/335 (41%), Positives = 203/335 (60%), Gaps = 15/335 (4%) Query: 7 RKALFQLDPERAHEFTFQQLRRITGTP-FEALVRQKVPAKP---VNCMGLTFKNPLGLAA 62 R LF L+PE AH + + L + P A + P+ P GL F +P+GLAA Sbjct: 9 RPWLFLLEPEHAHALSLRVLGGLNEMPKTRAHLWPHRPSDPRLAQELWGLHFAHPVGLAA 68 Query: 63 GLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDN 122 G DKDG+ + +L ++GF +E+GTVTPRPQPGN PR+FR +INR+GF + G Sbjct: 69 GFDKDGQALKSLASVGFAFLELGTVTPRPQPGNPGPRIFRYPQQRAVINRLGFPSQGGSA 128 Query: 123 LVENVKKAHYDGV-LGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGL 181 + + + V LGINIGKN++TP+ DY ++++ +A YI+IN+SSPNTP L Sbjct: 129 VADRLAATLPLTVPLGINIGKNRETPLTAAVGDYRALIQQLGPFADYISINVSSPNTPEL 188 Query: 182 RTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHN--- 238 R LQ ++L LL ++ + LQ + P+ +KIAPDL+ +E+ +A +L + Sbjct: 189 RRLQDPQSLRPLLQELREARQKLQ----RQPPLLLKIAPDLAPDEVTALA-ALAQEPQPL 243 Query: 239 IDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGI 298 +DG IATNTTL R + + GGLSG PL+ ++ II +L +GRLPIIGVGG+ Sbjct: 244 LDGFIATNTTLGRP--SDWPHPAEAGGLSGAPLKRRANGIIAQLYRASSGRLPIIGVGGV 301 Query: 299 DSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIV 333 + +KI AGASLVQ+Y+ I++GP L+++I Sbjct: 302 ATAQDVLDKIEAGASLVQLYTALIYEGPDLVQQIT 336 >UniRef50_C1EIH8 Dihydropryrimidine dehydrogenase n=1 Tax=Micromonas sp. RCC299 RepID=C1EIH8_9CHLO Length = 488 Score = 239 bits (611), Expect = 8e-62, Method: Compositional matrix adjust. Identities = 144/368 (39%), Positives = 203/368 (55%), Gaps = 45/368 (12%) Query: 3 YPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAA 62 + ++ A+ +DPE AH + L R P E R+ PA V+ GL F NP+GLAA Sbjct: 93 FEYLAPAMRLMDPETAHNVGIELLARGV-APVE--TRRDPPALAVDAWGLRFANPIGLAA 149 Query: 63 GLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDN 122 G DKD + ALGAMGFG +EIG+VTP+PQPGN KPR+FRL + +INR GFN+ G + Sbjct: 150 GFDKDAKAFPALGAMGFGFVEIGSVTPKPQPGNPKPRVFRLRELGAVINRYGFNSEGHEP 209 Query: 123 LVENVK---------KAHYDGV----------------------LGINIGKNKDTPVEQG 151 ++ ++ +D +G+N+GKNK TP Sbjct: 210 ARARLEAYRADTRATQSEFDATPVTPVTPEGAGVPRRLAERGAPVGVNLGKNKLTPEAAA 269 Query: 152 KDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLL---------TAIKNKQN 202 DDY + + + A YI +NISSPNTPGLR LQ L LL +A+K++ Sbjct: 270 ADDYALGVRALGHTADYIVVNISSPNTPGLRALQGKAHLKGLLRKVLAARDESALKSRTG 329 Query: 203 DLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSL-VQGMKNCD 261 Q HK P+ +KIAPDL++ ++ V + +DG+I +NTT+ R V Sbjct: 330 GGQTHAHK-PPVLLKIAPDLTDGDIKDVVAAATSCAVDGIIVSNTTIARPEDVAAHARGG 388 Query: 262 QTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGF 321 + GGLSG+PL STE++ R+ G++P++G GG+ S A EKI AGASLVQ+Y+ F Sbjct: 389 EAGGLSGKPLMDPSTEVLFRVYQLTGGKIPLVGCGGVASGRDAYEKIRAGASLVQMYTAF 448 Query: 322 IFKGPPLI 329 + GP L+ Sbjct: 449 AYAGPALV 456 >UniRef50_C6XQ80 Dihydroorotate dehydrogenase n=1 Tax=Hirschia baltica ATCC 49814 RepID=C6XQ80_HIRBI Length = 362 Score = 238 bits (606), Expect = 3e-61, Method: Compositional matrix adjust. Identities = 136/326 (41%), Positives = 196/326 (60%), Gaps = 4/326 (1%) Query: 12 QLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNC--MGLTFKNPLGLAAGLDKDGE 69 QL PE AH T ++ + L +++ V+ GL NPLG+AAG DK+ + Sbjct: 14 QLPPETAHRATIAAMKFGLAGKAKPLSKKQSERLKVHLPISGLDLPNPLGIAAGFDKNAD 73 Query: 70 CIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKK 129 A+G G +E GTVTP+ Q GN KPRLFRL + G+INRMGFNN G+D+ V +K Sbjct: 74 AFVPSLALGCGFVECGTVTPQLQDGNPKPRLFRLKEDGGVINRMGFNNSGLDSFVHRLKN 133 Query: 130 -AHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGE 188 A GV+G N+G NK + E+ DY+ ++ ++ Y YI +NISSPNTPGLR LQ Sbjct: 134 GAANQGVVGANVGANKTSEGEKRVGDYVDGIKAVWQYCAYITLNISSPNTPGLRGLQNKS 193 Query: 189 ALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADS-LVRHNIDGVIATNT 247 L LLTA +++ H P+ +KIAPD+ EE + + D+ L+ + G+I +NT Sbjct: 194 DLSALLTAASETILEMEDRHKTKRPVFLKIAPDIDEEAIRDIVDTVLLAKGMTGLIVSNT 253 Query: 248 TLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREK 307 T++R +N QTGGLSG+PL KST+++++++ +G+L IIG GGI +A K Sbjct: 254 TIERPSFLQSENAKQTGGLSGKPLFEKSTQVLKQVARIADGQLDIIGAGGIHDAKSAYLK 313 Query: 308 IAAGASLVQIYSGFIFKGPPLIKEIV 333 I AGA Q+YS +++G LI EI+ Sbjct: 314 IRAGAHCFQLYSALVYEGAALIPEIL 339 >UniRef50_Q1GGD3 Dihydroorotate oxidase A n=18 Tax=Alphaproteobacteria RepID=Q1GGD3_SILST Length = 352 Score = 237 bits (605), Expect = 4e-61, Method: Compositional matrix adjust. Identities = 139/329 (42%), Positives = 192/329 (58%), Gaps = 14/329 (4%) Query: 10 LFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDGE 69 + +LDPE AH + + LR TP V P + GL+ NP+GLAAG DK+ E Sbjct: 12 MHRLDPETAHGLSIKALRAGL-TPRPGPVTS--PRLRTDVAGLSLPNPVGLAAGFDKNAE 68 Query: 70 CIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKK 129 + L GFG IE+G TPRPQPGN KPRLFRL + INR GFNN G+D + + + + Sbjct: 69 ALAPLSEAGFGFIEVGAATPRPQPGNPKPRLFRLSEDRAAINRFGFNNEGMDTIGKRLAQ 128 Query: 130 AHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEA 189 GV+G+N+G NKD+ E D+ + A+ + +N+SSPNT LR LQ +A Sbjct: 129 RPKSGVIGLNLGANKDS--EDRAQDFARVLSHCGAHLDFATVNVSSPNTEKLRDLQGKDA 186 Query: 190 LDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTL 249 L LL + + + LQ + +P+ +KIAPDL L +A+ ID VIATNTTL Sbjct: 187 LASLLAGVIDAREALQ----RPIPVFLKIAPDLDISGLDDIAEVARDSGIDAVIATNTTL 242 Query: 250 DRSLVQGMKNC--DQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREK 307 R G+K+ D+ GGLSG PL +ST ++ +LS L+G +PIIGVGGI + A K Sbjct: 243 SR---DGLKSTHRDEMGGLSGAPLFERSTRVLAQLSQRLDGAVPIIGVGGISTAEGAYAK 299 Query: 308 IAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 I AGAS VQ+Y+ ++ G L E+ + + Sbjct: 300 IRAGASAVQLYTALVYGGLSLASEVASGL 328 >UniRef50_Q5PR57 Dihydroorotate dehydrogenase n=20 Tax=cellular organisms RepID=Q5PR57_DANRE Length = 407 Score = 236 bits (602), Expect = 1e-60, Method: Compositional matrix adjust. Identities = 127/294 (43%), Positives = 188/294 (63%), Gaps = 12/294 (4%) Query: 47 VNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDA 106 V+ MG F+NP+G+AAG DK GE +D L +GFG +E+GTVTP+PQ GN KPR+FRL Sbjct: 79 VHVMGRKFQNPVGMAAGFDKHGEAVDGLYRLGFGFVEVGTVTPKPQDGNPKPRVFRLESD 138 Query: 107 EGLINRMGFNNLGVDNLVENVK-KAHYDGVL-------GINIGKNKDTPVEQGKDDYLIC 158 + +INR GFN+ G+ + E +K + H L GIN+GKNK +P DY+ Sbjct: 139 QAVINRYGFNSCGLSAVHERLKAREHVQSELTKAGKPLGINLGKNKLSP--DAVSDYVEG 196 Query: 159 MEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKI 218 + + A Y+ +N+SSPNTPGLR LQ E L LL + +++ L+ + P+ VKI Sbjct: 197 VRTLGPLADYLVVNVSSPNTPGLRDLQGKEELRHLLDKVVKERDSLRIENRP--PVLVKI 254 Query: 219 APDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEI 278 APDL+ ++ +A+ ++ +DGV+ +NTT+ R N +TGGLSG+PL+ ST+ Sbjct: 255 APDLTTQDKQDIAEVIMEVGVDGVMVSNTTVSRPDTLKDPNRVETGGLSGQPLKELSTQT 314 Query: 279 IRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 +R + G+LPI+GVGG+ S A +KI AGASLVQ+Y+ +++GPP++ +I Sbjct: 315 VREMYTLTQGKLPIVGVGGVASGQDAMDKIRAGASLVQLYTALVYQGPPVVNKI 368 >UniRef50_B5Z6I2 Dihydroorotate dehydrogenase n=28 Tax=Campylobacterales RepID=PYRD_HELPG Length = 351 Score = 233 bits (594), Expect = 6e-60, Method: Compositional matrix adjust. Identities = 137/339 (40%), Positives = 189/339 (55%), Gaps = 18/339 (5%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPF-----EALVRQKVPAKPVNCMGLTFK 55 M YP V+K LF LD E AHE + LR ++ + F + K P +GL F Sbjct: 1 MLYPLVKKYLFSLDAEDAHEKVCKILRTLSKSSFLCSLIHSQWGYKNPKLENEILGLNFP 60 Query: 56 NPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGF 115 NPLGLAAG DK+ + AL A GFG +E GT+T Q GN++PRLFR ++ E L N MGF Sbjct: 61 NPLGLAAGFDKNASMLRALIAFGFGYLEAGTLTNEAQVGNERPRLFRHIEEESLQNAMGF 120 Query: 116 NNLGVDNLVENVKK-AHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINIS 174 NN G + + A Y +GIN+GKNK +DY + + Y N+S Sbjct: 121 NNYGAVLGARSFNRFAPYKTPIGINLGKNKHIEQAHALEDYKAVLNQCLNIGDYYTFNLS 180 Query: 175 SPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSL 234 SPNTP LR LQ +++L K M HK P+ +KIAPDL ++++++ +S Sbjct: 181 SPNTPNLRDLQNKAFVNELFCMAKE-------MTHK--PLFLKIAPDLEIDDMLEIVNSA 231 Query: 235 VRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIG 294 + G+IATNTT+D+SLV K + GGLSG+ L KS E+ + L+ + ++ Sbjct: 232 IEAGAHGIIATNTTIDKSLVFAPK---EMGGLSGKCLTKKSREVFKELAKAFFNKSVLVS 288 Query: 295 VGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIV 333 VGGI A E+I GASL+QIYS FI+ GP L + I+ Sbjct: 289 VGGISDAKEAYERIKMGASLLQIYSAFIYNGPNLCQNIL 327 >UniRef50_Q02127 Dihydroorotate dehydrogenase, mitochondrial n=39 Tax=cellular organisms RepID=PYRD_HUMAN Length = 395 Score = 233 bits (594), Expect = 7e-60, Method: Compositional matrix adjust. Identities = 144/331 (43%), Positives = 202/331 (61%), Gaps = 21/331 (6%) Query: 13 LDPERAHEFTFQQLRRITGTPFEALVR-QKVPAKPVNCMGLTFKNPLGLAAGLDKDGECI 71 LDPE AH R T R Q V +G F+NP+G+AAG DK GE + Sbjct: 49 LDPESAHRLAV----RFTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAV 104 Query: 72 DALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKKAH 131 D L MGFG +EIG+VTP+PQ GN +PR+FRL + + +INR GFN+ G+ ++VE+ +A Sbjct: 105 DGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGL-SVVEHRLRAR 163 Query: 132 Y--------DGV-LGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLR 182 DG+ LG+N+GKNK T V+ +DY + + A Y+ +N+SSPNT GLR Sbjct: 164 QQKQAKLTEDGLPLGVNLGKNK-TSVD-AAEDYAEGVRVLGPLADYLVVNVSSPNTAGLR 221 Query: 183 TLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGV 242 +LQ L LLT + +++ L+ +H V VKIAPDL+ ++ +A + IDG+ Sbjct: 222 SLQGKAELRRLLTKVLQERDGLRRVHRPAV--LVKIAPDLTSQDKEDIASVVKELGIDGL 279 Query: 243 IATNTTLDR-SLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSV 301 I TNTT+ R + +QG +TGGLSG+PL+ ST+ IR + GR+PIIGVGG+ S Sbjct: 280 IVTNTTVSRPAGLQGALRS-ETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSG 338 Query: 302 IAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 A EKI AGASLVQ+Y+ F GPP++ ++ Sbjct: 339 QDALEKIRAGASLVQLYTALTFWGPPVVGKV 369 >UniRef50_B7G8S8 Predicted protein n=2 Tax=Bacillariophyta RepID=B7G8S8_PHATR Length = 456 Score = 233 bits (593), Expect = 1e-59, Method: Compositional matrix adjust. Identities = 153/348 (43%), Positives = 210/348 (60%), Gaps = 37/348 (10%) Query: 13 LDPERAHE---FTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDGE 69 LDPE AH F +Q P AL ++ V + V G TF NP+GLAAG DKDGE Sbjct: 59 LDPETAHHAGIFFAEQGLSPRFRP-SALEQRCVVSNSV--FGKTFPNPIGLAAGFDKDGE 115 Query: 70 CIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKK 129 + + +GFG +EIGTVTP+ QPGN KPR+FRLV+ G+INR GFN+ G + +N+K Sbjct: 116 VVQEMLDLGFGFVEIGTVTPQAQPGNPKPRMFRLVEDLGIINRYGFNSQGASTVEKNLKS 175 Query: 130 -------------------------AHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYA 164 H G++G+NIGKNK++ G DY+ + ++ + Sbjct: 176 FRSPQPIDSAKLSWPRYIWNFLYPPRHQSGLVGVNIGKNKNSLDAIG--DYVCNIRQLSS 233 Query: 165 YAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSE 224 A Y+ +NISSPNT GLR LQ +L LLT +N+ M H+ VP+ VK+APDL++ Sbjct: 234 LADYMVLNISSPNTAGLRDLQQANSLRVLLTTCLTTRNE---MTHR-VPLLVKLAPDLTD 289 Query: 225 EELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSL 284 EEL Q+A+ + IDG+I TNTT R K+ + GGLSG+P++ +STE IRRL Sbjct: 290 EELDQIANVCLEVGIDGIIITNTTNHRPADLLSKHRGEIGGLSGKPVKDQSTECIRRLFR 349 Query: 285 ELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 +G++PIIGVGG+ S A EK+ AGASLVQ+YS +++GP +I I Sbjct: 350 LTDGKIPIIGVGGVGSGHDAYEKLKAGASLVQVYSMMVYQGPGVISRI 397 >UniRef50_B9L4A8 Dihydroorotate oxidase n=2 Tax=Thermomicrobia (class) RepID=B9L4A8_THERP Length = 374 Score = 232 bits (591), Expect = 1e-59, Method: Compositional matrix adjust. Identities = 134/338 (39%), Positives = 193/338 (57%), Gaps = 14/338 (4%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKP------VNCMGLTF 54 Y V LF+LDPE AH L R++ P V ++V P V LTF Sbjct: 15 WYRRIVTPLLFRLDPEDAHRLVLGVLSRLSRCPGSERVLRRVFRVPDDERLRVEVGDLTF 74 Query: 55 KNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMG 114 NP+GLAAG+DK+ E + A +GFGS+E+GTVTP PQ GN +PRL+R + E L+N +G Sbjct: 75 PNPIGLAAGVDKNAEAVAAWFGLGFGSVEVGTVTPCPQEGNPRPRLWRFPEDETLVNALG 134 Query: 115 FNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINIS 174 F + GV + + + G +GIN+GKN TP+EQ DY + ++ A Y+ +N+S Sbjct: 135 FPSDGVAAVRARLVGRWFPGPVGINLGKNAWTPLEQAVVDYCATLVALWDVADYVVVNVS 194 Query: 175 SPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHH-KYVPIAVKIAPDLSEEELIQVADS 233 SPNTPGLR LQ GE L+ +L A++ L A+ + P+ VK++ DL L + Sbjct: 195 SPNTPGLRELQRGERLEQVLAAVQETNRTLAALQRARPRPLFVKVSLDLDAGALADAIEI 254 Query: 234 LVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPII 293 V DG+I NT++D SL GG+SGRPL+ ++ E++ + GRL +I Sbjct: 255 AVAVGADGLILGNTSIDPSLRPAGAGA-LPGGVSGRPLRKRAVELLSNAADRAGGRLALI 313 Query: 294 GVGGI---DSVIAAREKIAAGASLVQIYSGFIFKGPPL 328 VGG+ D VI +++ GA LVQ+Y+G +F+GP L Sbjct: 314 SVGGVLETDDVI---QRLRLGADLVQVYTGLVFRGPAL 348 >UniRef50_C3XDT6 Dihydroorotate dehydrogenase n=4 Tax=Helicobacter RepID=C3XDT6_9HELI Length = 357 Score = 231 bits (588), Expect = 4e-59, Method: Compositional matrix adjust. Identities = 129/339 (38%), Positives = 197/339 (58%), Gaps = 17/339 (5%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGTP-FEALVRQKVPAKPVNCM----GLTFKN 56 +Y +R L++ D E+ H F + ++ P FE+++ + N GL F N Sbjct: 3 FYKKIRPYLYKCDAEKIHNFAIKVMKMPQKIPLFESMIAKCYCRIHENLAQDIHGLHFYN 62 Query: 57 PLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFN 116 P+GLA+G DK+ E + L ++GFG +E+G+VT PQ GN+KPR+FR V+ E L N MGFN Sbjct: 63 PIGLASGFDKNAEAVRPLASLGFGYLELGSVTQMPQDGNEKPRMFRHVEEESLQNAMGFN 122 Query: 117 NLGVDNLVENVKKAHYDGV-LGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISS 175 N+G ++ ++K+ + + LGINIGKNK+ +Y + ++ + Y Y N+SS Sbjct: 123 NIGARGMLAHLKEVYPFCIPLGINIGKNKNIAQGDSLKNYELSLDTLKDYGDYFTFNLSS 182 Query: 176 PNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLV 235 PNTPGLR LQ + +L+ K+ N PI +KI+PD+ E ++ V D+ + Sbjct: 183 PNTPGLRDLQNESFVKELMEMAKSTTNK---------PIFIKISPDMEIESMLAVCDAAI 233 Query: 236 RHNIDGVIATNTTLDRSLVQG--MKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPII 293 ++ ++G+IATNT++D SLV KN GGLSG+ + KS E++R L + + +I Sbjct: 234 QNGVNGIIATNTSIDYSLVSNPVKKNDVCFGGLSGKAISTKSKEVLRILGKNFHKKTTLI 293 Query: 294 GVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 VGGI E+I GASLVQI S I++GP LI + Sbjct: 294 SVGGIGDSNEVYERIKLGASLVQILSSMIYEGPTLISRM 332 >UniRef50_P32748 Dihydroorotate dehydrogenase, mitochondrial n=14 Tax=Drosophila RepID=PYRD_DROME Length = 405 Score = 231 bits (588), Expect = 4e-59, Method: Compositional matrix adjust. Identities = 124/291 (42%), Positives = 190/291 (65%), Gaps = 14/291 (4%) Query: 50 MGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGL 109 G NP+G+AAG DK+ E +D L +GFG IE+GTVTP Q GN KPR+FRL + + + Sbjct: 91 FGRMLSNPIGIAAGFDKNAEAVDGLQDLGFGFIEVGTVTPAAQEGNPKPRVFRLTEDKAI 150 Query: 110 INRMGFNNLGVDNLVENV----KKAHYDGVLGINIGKNKDT--PVEQGKDDYLICMEKIY 163 INR GFN+ G +++ + KK +++GV+G+N+G+NK T P+ DY+ + Sbjct: 151 INRYGFNSDGHQAVLQRLRLLRKKENFNGVVGVNLGRNKTTMSPIA----DYVQGVRVFG 206 Query: 164 AYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLS 223 A Y+ IN+SSPNT GLR +Q E L +LL + + ++ L +K VPI +K++PDLS Sbjct: 207 PVADYLVINVSSPNTKGLRDMQSKEKLRELLEQVNDTKSSLD--KNKNVPILLKLSPDLS 264 Query: 224 EEELIQVADSLVRHN--IDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRR 281 +++ + + R +DG+I +NTT+ R ++ K ++TGGLSG PL+ +STE+I + Sbjct: 265 LDDMKDIVWVIKRKKSRVDGLIVSNTTVSRENIEKNKLAEETGGLSGPPLKARSTEMIAQ 324 Query: 282 LSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 + +G++PIIGVGG+ S A EKI AGAS VQIY+ +++GP L+++I Sbjct: 325 MYQLTDGKIPIIGVGGVASGYDAYEKIEAGASYVQIYTALVYEGPALVEDI 375 >UniRef50_B7JXU8 Dihydroorotate dehydrogenase n=8 Tax=Cyanobacteria RepID=PYRD_CYAP8 Length = 377 Score = 229 bits (585), Expect = 9e-59, Method: Compositional matrix adjust. Identities = 130/295 (44%), Positives = 185/295 (62%), Gaps = 18/295 (6%) Query: 50 MGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGL 109 GLTF NP+GLAAG DK+G +GFG E+G VT PQPGN +PRLFRL + + Sbjct: 66 WGLTFNNPVGLAAGCDKEGIAAGIWSHLGFGFAELGAVTLHPQPGNPRPRLFRLPHDKAV 125 Query: 110 INRMGFNNLGVD----NLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAY 165 +NR+G NN G + L E +++ + +GIN+ K+K TP+++ DY+ + Sbjct: 126 LNRLGANNQGAEIMAQTLAEIWQRSPRNIPIGINLCKSKITPLDEAAQDYVGSFSYLENQ 185 Query: 166 AGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEE 225 A Y +N+SSPNTPGLR+LQ GE L+ +L A LQA + P+ VKI+PDL EE Sbjct: 186 ADYFVVNVSSPNTPGLRSLQEGEQLNSILQA-------LQAANQHQKPLFVKISPDLEEE 238 Query: 226 ELIQVADSLVRHNIDGVIATNTTL--DRSLVQ-----GMKNCDQTGGLSGRPLQLKSTEI 278 ++ + + H + G+IATNTT+ DR Q G K ++ GG+SG P++ +STEI Sbjct: 239 AILTIIELAQTHCLAGIIATNTTIKRDRLTTQILPETGNKIQEEAGGISGLPIRDRSTEI 298 Query: 279 IRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIV 333 I + + G+LPIIGVGGI + A KI AGASL+Q+Y+G+I++GP +I +IV Sbjct: 299 IGFIYQKTQGKLPIIGVGGIFTPDDAWNKIIAGASLLQLYTGWIYQGPWIIPDIV 353 >UniRef50_Q75XR0 Dihydroorotate dehydrogenase n=3 Tax=Eukaryota RepID=Q75XR0_EUGGR Length = 435 Score = 227 bits (579), Expect = 4e-58, Method: Compositional matrix adjust. Identities = 129/295 (43%), Positives = 179/295 (60%), Gaps = 17/295 (5%) Query: 47 VNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDA 106 + GL F NPLGLAAG DK GE +DAL GFG +EIGTVTP PQPGN PR+FRL Sbjct: 100 MEVWGLKFSNPLGLAAGFDKHGEAVDALLGTGFGFVEIGTVTPLPQPGNPSPRMFRLEQD 159 Query: 107 EGLINRMGFNNLGVDNLVENV-----KKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEK 161 +INR GFN+ G+ + + + + A G++G+N+GKNK E DY + + Sbjct: 160 RAIINRYGFNSQGLAAVRKRLEARQHRPAPRGGLVGVNVGKNKLQ--EDAAADYSKGLRE 217 Query: 162 IYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDL-------QAMHHKY--- 211 + YA Y+ IN+SSPNTPGLR LQ A+ DL+ A ++++ +A K Sbjct: 218 LGPYADYLVINVSSPNTPGLRNLQKRSAMADLIKASMVARDEVVRDADGRRAAAGKSAAP 277 Query: 212 VPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPL 271 +P+ +KIAPDL+ EE +A+ ++ IDG+I +NTT+ R + QTGGLSG PL Sbjct: 278 LPLLIKIAPDLTAEEKQDIAEVVMETKIDGLIVSNTTVSRPASLLSPHKGQTGGLSGAPL 337 Query: 272 QLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGP 326 + ST+ IR + G +PI+GVGG+ + EK+ AGASLVQ+YS ++ GP Sbjct: 338 REMSTQAIRDMYALTRGTVPIVGVGGVATGEDVLEKLKAGASLVQMYSMLVYDGP 392 >UniRef50_D2UZD6 Predicted protein n=1 Tax=Naegleria gruberi RepID=D2UZD6_NAEGR Length = 369 Score = 227 bits (578), Expect = 5e-58, Method: Compositional matrix adjust. Identities = 128/344 (37%), Positives = 205/344 (59%), Gaps = 30/344 (8%) Query: 13 LDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPV-----NCMGLTFKNPLGLAAGLDKD 67 +DPE AH + ++ G + L + P+ NC+G F+NP+GLAAG DKD Sbjct: 1 MDPEDAHNLSKLAIKYGIGPKEKKLKANQYGLDPLISLHTNCLGYHFENPIGLAAGFDKD 60 Query: 68 GECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRL----VDAEG-----LINRMGFNNL 118 EC+ + +GFG +E+G++ P+PQPGN KPR+FRL D +G ++NR GFN+ Sbjct: 61 AECMKGIEKLGFGFMEVGSICPQPQPGNPKPRIFRLNSKVSDPDGTIFDTILNRCGFNSK 120 Query: 119 GVDNLVENVK--KAHYDGV----LGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAIN 172 G++ EN+ + Y + +G+N+GKNK T + +DYLI + K+ +A ++ IN Sbjct: 121 GMEVSDENLTTYRNSYQSLNTFPIGVNLGKNK-TSAPESIEDYLIGVRKLAKHADFLVIN 179 Query: 173 ISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVAD 232 +SSPNT LR+LQ +LD L+ + + HK +P+ +KIAPDL+ ++ +A Sbjct: 180 VSSPNTQHLRSLQEKSSLDTLIEEVST-----ELKKHKNIPLLIKIAPDLTLDQQRDIAS 234 Query: 233 SLVRHNIDGVIATNTTLDRSLVQGMK----NCDQTGGLSGRPLQLKSTEIIRRLSLELNG 288 ++H+I G+I +NTT++R V + GG+SGRPL +ST++++ + G Sbjct: 235 LALKHSIGGIIVSNTTIERPFVSSEQINAIPNGSAGGMSGRPLFNQSTKVLKNMYKLTEG 294 Query: 289 RLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 ++ +IGVGG+ A +KI AGASLVQ+Y+ F +GP ++ +I Sbjct: 295 KVTLIGVGGVWDGYDALQKIQAGASLVQVYTAFTAQGPAVVGKI 338 >UniRef50_Q9RX14 Dihydroorotate dehydrogenase n=4 Tax=Bacteria RepID=PYRD_DEIRA Length = 369 Score = 227 bits (578), Expect = 5e-58, Method: Compositional matrix adjust. Identities = 138/348 (39%), Positives = 197/348 (56%), Gaps = 21/348 (6%) Query: 3 YPFVRKALFQLDPERAHEFTFQQLRRITGTPF-----------------EALVRQKVPAK 45 Y VR LF+LD E AH T + L +G P +A +R+ + + Sbjct: 2 YQTVRPLLFRLDAEDAHHLTLRGLELASGVPLLPRLARTLTVPGTQGPGDAALRRTLWGQ 61 Query: 46 PVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVD 105 + TF++PLGLAAGLDK+ + + A A GFG +E+GTVTP Q GN++PRLFRL + Sbjct: 62 TPSEQ--TFESPLGLAAGLDKNAQAVPAFTAFGFGFVEVGTVTPLAQSGNERPRLFRLPE 119 Query: 106 AEGLINRMGFNNLGVDNLVENVKK-AHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYA 164 E LINRMGFNN G + + + +NIGKNK TP E +DY C+ + Sbjct: 120 DEALINRMGFNNGGTAAMHARLAVLTDRAAPVWVNIGKNKVTPNEDAAEDYRKCVRALGD 179 Query: 165 YAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSE 224 A +N+SSPNTPGLR LQ + L L+ A+ ++ + + P+ VK+APDL Sbjct: 180 LADAFVVNVSSPNTPGLRALQAADDLAALVRAVLDEVEAGRVRTLRRPPVLVKLAPDLHP 239 Query: 225 EELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSL 284 + +++ G+I +NTTL R + N +Q GGLSGRPL +STE++R Sbjct: 240 ADFEASVGAVLDAGASGLIISNTTLSRGGLS-HPNREQAGGLSGRPLTDRSTELVRDAYR 298 Query: 285 ELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 G++PI+GVGG+ S A K+ AGA LV++YS I++GP L++EI Sbjct: 299 LTRGQVPIVGVGGVFSAEDAYAKLLAGADLVEVYSALIYRGPGLVREI 346 >UniRef50_B9L9P6 Dihydroorotate dehydrogenase n=7 Tax=Epsilonproteobacteria RepID=PYRD_NAUPA Length = 359 Score = 226 bits (577), Expect = 7e-58, Method: Compositional matrix adjust. Identities = 133/338 (39%), Positives = 201/338 (59%), Gaps = 20/338 (5%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGTP--FEALVRQKVPAKPV---NCMGLTFKN 56 ++ V+ +++ DPE AH+ +R P F LV+ + L FKN Sbjct: 3 FFNMVKPLIYKTDPELAHDLVDLAMRTARRCPLFFNPLVKANFVDDVMLHQKIWDLEFKN 62 Query: 57 PLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFN 116 P+G+AAG DK + A+GFG EIG VTP+PQPGN+KPR +R ++ E + N GFN Sbjct: 63 PVGVAAGFDKHATMVYGWPALGFGWGEIGAVTPKPQPGNEKPRAWRHIEYEAVQNAYGFN 122 Query: 117 NLGVDNLVENVKKAH-YDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISS 175 N GV+ + + +KK + + +G NIGKNK TP E+ +DY I + ++ + +N+SS Sbjct: 123 NEGVEVIKKRLKKIYPFILPIGANIGKNKTTPEERAVEDYKILVNELKDVVDFFVVNVSS 182 Query: 176 PNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLV 235 PNTPGLR L E + L +KN + PI +K +PD+ +E +I +A+ V Sbjct: 183 PNTPGLRDLLNAEFISSLFGELKNLTDK---------PILIKFSPDMEDELIINLANYSV 233 Query: 236 RHNIDGVIATNTTLDRSLVQGMKNCD-QTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIG 294 DG+I TNTT++ LV N + + GG+SG+PL +S E++R ++ E+ G++PII Sbjct: 234 LAGADGIIVTNTTVNYDLV----NSEIKRGGISGKPLAQRSYEVLRIVAGEVFGKVPIIS 289 Query: 295 VGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 VGGIDS A ++I AGASL+Q+Y+ I+KGP ++ EI Sbjct: 290 VGGIDSAEEAYKRIKAGASLLQVYTAIIYKGPGIVGEI 327 >UniRef50_B9KHW9 Dihydroorotate dehydrogenase (PyrD) n=10 Tax=Rickettsiales RepID=B9KHW9_ANAMF Length = 389 Score = 226 bits (576), Expect = 8e-58, Method: Compositional matrix adjust. Identities = 133/337 (39%), Positives = 199/337 (59%), Gaps = 17/337 (5%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVP-AKPVNCMGLTFKNPLGL 60 ++ F F + PE AH L+ G E VR ++P + L F+ P+GL Sbjct: 39 FFRFSHSPRFWVPPEVAHGLVIFGLKH--GLFPE--VRGQMPECLSIEVCHLRFRTPIGL 94 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAG DK+ E I L MGFG +E GTVT +PQ GN +PRLFR+VD + ++NR+GFNN G+ Sbjct: 95 AAGFDKNAEVIKPLIGMGFGFVEAGTVTKKPQSGNKRPRLFRIVDQKAVVNRLGFNNKGI 154 Query: 121 DNLVENVKKAHYDG-VLGINIGKNK---DTPVEQGKDDYLICMEKIYAYAGYIAINISSP 176 ++ + + + V G N+G NK D P E Y + +Y + YI IN+SSP Sbjct: 155 QRFIKKIDRKELNNLVFGANLGINKTCTDPPAE-----YAEMVRSVYGLSSYITINVSSP 209 Query: 177 NTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVR 236 NT GLR LQ L ++L+++++ + + + VPI +KIAPD+S+E +A+ +V+ Sbjct: 210 NTAGLRDLQNRGPLSEILSSVRDARRSVD--QAESVPIFLKIAPDISDELKQDIAEEIVK 267 Query: 237 HNIDGVIATNTTLDRSLVQGMKNCDQT-GGLSGRPLQLKSTEIIRRLSLELNGRLPIIGV 295 H I G+I +NTT D SL+ +N T GGLSGRPL ST ++ + L ++ +IG Sbjct: 268 HKISGLIVSNTTTDLSLLGKDRNKSITQGGLSGRPLFDLSTTVLSEMYSLLRDKVILIGC 327 Query: 296 GGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 GG+ S A +KI AGASLVQ+Y+ +++G ++K+I Sbjct: 328 GGVSSGAQALQKIKAGASLVQLYTALVYEGFGVVKKI 364 >UniRef50_B3CMR9 Dihydroorotate dehydrogenase n=10 Tax=Rickettsiales RepID=B3CMR9_WOLPP Length = 355 Score = 226 bits (576), Expect = 8e-58, Method: Compositional matrix adjust. Identities = 129/335 (38%), Positives = 195/335 (58%), Gaps = 18/335 (5%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRI-TGTPFEALVRQKVPAK-PVNCMGLTFKNPL 58 Y +R LF L PE AH L+++ P E +P VN G ++P+ Sbjct: 12 FYKMILRNLLFLLPPEIAHSLVITALKKMPCRKPIE------LPKSLNVNFFGNKIRSPV 65 Query: 59 GLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNL 118 GLAAG DK+ E + + + GFG IE GTVT PQ GN KPR+FRL+ EG+INR+GFNN Sbjct: 66 GLAAGFDKNAEVVKPMLSFGFGFIEAGTVTKHPQYGNKKPRIFRLIKDEGIINRLGFNNK 125 Query: 119 GVDNLVENVKKAHY-DGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPN 177 GVD ++ + + + + GINIG+N + + DY+ ++ +Y + YI +NISSPN Sbjct: 126 GVDYFLKQISETKLGNCIFGINIGRNSTS--KDQISDYVDLIKIVYGKSNYIVLNISSPN 183 Query: 178 TPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRH 237 TP LR L + L LL +I + + + +PI +KI+PD+ ++ +A+ + + Sbjct: 184 TPNLRDLHNKQELSKLLKSITLTRKSIDSSES--IPIILKISPDIDQQTKENIAELTLEY 241 Query: 238 NIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGG 297 IDG+I +NTT+ R +++GGLSGRPL STE++ + R+ +IG GG Sbjct: 242 KIDGLIVSNTTISRD-----SYYNESGGLSGRPLFQLSTELLSDMYKLTKSRILLIGCGG 296 Query: 298 IDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 I S + A EKI AGASLVQ+Y+ +++G ++ +I Sbjct: 297 ISSGVDAYEKIKAGASLVQLYTALVYQGHQVVNKI 331 >UniRef50_B0MVX7 Putative uncharacterized protein n=1 Tax=Alistipes putredinis DSM 17216 RepID=B0MVX7_9BACT Length = 356 Score = 226 bits (576), Expect = 1e-57, Method: Compositional matrix adjust. Identities = 129/343 (37%), Positives = 191/343 (55%), Gaps = 18/343 (5%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTP-----FEALVRQKVPAKPVNCMGLTFK 55 MY ++ LF ++ ERAH LR I P A+ R + P+ GL F Sbjct: 1 MYRKLIKPILFAMNIERAHSTVLFLLRMIGKIPGGRALLRAMYRTEHPSLEREVFGLRFP 60 Query: 56 NPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGF 115 NP+GLAAG D++GE L A+GFG +EIGTVTP+PQ GN +PR+FRL +INR G Sbjct: 61 NPIGLAAGFDRNGEAFRELSALGFGFVEIGTVTPQPQAGNPRPRIFRLPADRAIINRSGL 120 Query: 116 NNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISS 175 NN G+ + ++ H ++G NIGKN T Q DYL +Y Y Y +IN+ Sbjct: 121 NNKGLYKAIAQLRHRHDRLIIGGNIGKNTLTQPSQVAADYLKMFRNLYQYVDYFSINVCC 180 Query: 176 PNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLV 235 N L ++L + D + ++Y PI +KI+PDL + + +V D ++ Sbjct: 181 DNCADGSVSHNKAHLMNILQPL----FDFRRGQNQYRPILLKISPDLPDPLIDEVTDLML 236 Query: 236 RHNIDGVIATNTTLDRSLVQGMKNCDQT------GGLSGRPLQLKSTEIIRRLSLELNGR 289 +DG++A N T R +G++ ++T G LSG PL ++ E++RR+ +G Sbjct: 237 STPLDGIVAVNGTFSR---KGLETDEETLDEIGSGRLSGAPLTQRAIEVVRRIHRRSHGA 293 Query: 290 LPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 PIIGVGG+ + + +AAGASLVQ+Y+G+I++GP L+KEI Sbjct: 294 YPIIGVGGLMNARDVKAMLAAGASLVQLYTGYIYEGPSLVKEI 336 >UniRef50_A8WW30 C. briggsae CBR-DHOD-1 protein n=3 Tax=Caenorhabditis RepID=A8WW30_CAEBR Length = 426 Score = 225 bits (573), Expect = 2e-57, Method: Compositional matrix adjust. Identities = 136/320 (42%), Positives = 190/320 (59%), Gaps = 32/320 (10%) Query: 39 RQKVPAKPVNCMGLTFKNPLGLAAGLDKDGECIDALGA-MGFGSIEIGTVTPRPQPGNDK 97 R++ P G F+NP+GLAAG DKDG+ I L GFG IEIG+VTP PQPGN++ Sbjct: 84 RKEYPELKCELFGREFRNPIGLAAGFDKDGQAITQLAKNSGFGLIEIGSVTPIPQPGNNR 143 Query: 98 PRLFRLVDAEGLINRMGFNNLGVDNLVENVKKAHYDGV------LGINIGKNKDTPVEQG 151 PR+FRL++ EG+INR GFN+ GV + + V+ A V G+N+GKNK T E Sbjct: 144 PRVFRLLEDEGVINRYGFNSDGVGRVHQRVRSARDAWVPEQYAYFGVNLGKNKLT--EDA 201 Query: 152 KDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMH--H 209 K DY I + + Y+ +N+SSPNTPGLR++Q L+ LL +K + MH Sbjct: 202 KLDYEIGVNYFAPHCDYLVLNVSSPNTPGLRSMQKKSDLEKLLAYVKESLD----MHKLE 257 Query: 210 KYVPIAVKIAPDLSEEELIQVADSLV--RHNIDGVIATNTTLDRSLVQGMKNCDQTGGLS 267 K I +KIAPDL + E+ +A + + +DG+I +NTT+ R +N +TGGLS Sbjct: 258 KRPQIFLKIAPDLIDSEMKDIAHVVTNKKFGVDGIIVSNTTIARPDYLKSENKAETGGLS 317 Query: 268 GRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKI---------------AAGA 312 G P++ STE IR++ NG++PIIG GG+ S A EKI +AG Sbjct: 318 GAPVREISTECIRKMYKLTNGQIPIIGCGGVFSGEDAYEKIRYNRRNAIDSNYNIFSAGG 377 Query: 313 SLVQIYSGFIFKGPPLIKEI 332 SLVQ+YS F+++G P+I +I Sbjct: 378 SLVQLYSAFVYEGFPVIGKI 397 >UniRef50_C4QIG2 Dihydroorotate dehydrogenase n=3 Tax=Schistosoma RepID=C4QIG2_SCHMA Length = 379 Score = 224 bits (570), Expect = 5e-57, Method: Compositional matrix adjust. Identities = 135/314 (42%), Positives = 188/314 (59%), Gaps = 24/314 (7%) Query: 39 RQKVPAKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKP 98 R P GL F +P+GLAAG DKDG+ L GF IE+GTVTP PQ GN +P Sbjct: 67 RNSFPQLKCKVFGLEFDHPIGLAAGFDKDGKAFMGLLNAGFSHIEVGTVTPNPQLGNARP 126 Query: 99 RLFRLVDAEGLINRMGFNNLGVDNLVENVKKAHYD--GVLGINIGKNKDTPVEQGKDDYL 156 R+FR + E ++NR GFN+ G D + E +K ++ GV+G+N+G NK + DY+ Sbjct: 127 RIFRWTEKEAVVNRCGFNSDGHDAVYERLKDRPWEGRGVIGVNLGCNKTSADPTA--DYV 184 Query: 157 ICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAV 216 + K A Y+ IN+SSPNTPGLR+LQ E L DLL+ + +N L K PI + Sbjct: 185 AGVRKFGEVADYLVINVSSPNTPGLRSLQTKEKLRDLLSKVLAARNQLS----KKTPILL 240 Query: 217 KIAPDLSEEEL---IQVA-DSLVRHNIDGVIATNTTL---DRSLVQGMK----NCDQT-- 263 KI+PD +++ L ++VA DS R IDG+I +NTTL + ++ G N Q Sbjct: 241 KISPDENDQNLKDIVEVALDSKTR--IDGMIISNTTLTTYEEAVACGAAPIPGNNKQNVV 298 Query: 264 -GGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFI 322 GGLSGRPL KST+ +R++S G +P+IGVGGI A K+ AGASLVQ+Y+ F+ Sbjct: 299 YGGLSGRPLFEKSTDCLRKVSALTKGAIPLIGVGGISCGEDALSKLNAGASLVQLYTSFV 358 Query: 323 FKGPPLIKEIVTHI 336 ++GPP+ ++ I Sbjct: 359 YQGPPVAHKVAREI 372 >UniRef50_Q5UF20 Predicted dihydroorotate dehydrogenase n=1 Tax=uncultured alpha proteobacterium EBAC2C11 RepID=Q5UF20_9PROT Length = 378 Score = 223 bits (569), Expect = 6e-57, Method: Compositional matrix adjust. Identities = 137/343 (39%), Positives = 186/343 (54%), Gaps = 16/343 (4%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 M + + K L E AH+ L G P A RQ V GL F NPLGL Sbjct: 1 MMWNLLAKLARHLPAEAAHQIAVAALHYNVG-PRPAQ-RQSKADLTVRIAGLEFANPLGL 58 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAG DK+ C + +GF +E+GT+TP+ QPGN KPR+FRL + +INR GFN+ G+ Sbjct: 59 AAGFDKNATCFNGAMGLGFAHVEVGTITPKRQPGNPKPRVFRLPEENAVINRYGFNSHGM 118 Query: 121 DNLVENV--KKAHYDGVLGINIGKNKDT--PVEQGKDDYLICMEKIYAYAGYIAINISSP 176 D + +N+ + G+LG+N+G NK + P+ DDY + + YA YI +NISSP Sbjct: 119 DRVAKNLYATASKRVGILGVNVGANKTSNDPI----DDYRQAVAMLAPYADYITLNISSP 174 Query: 177 NTPGLRTLQYGEALDDLLTA------IKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQV 230 NTPGLR LQ L DLL A + ++ + PI +KIAPDL ++L + Sbjct: 175 NTPGLRNLQTKRHLADLLMAGFAGCREAGFEPACRSTGLRQKPIFLKIAPDLRHDDLATI 234 Query: 231 ADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRL 290 DS V G+IATNTT+ R + + GGLSG PL ST I+ ++ RL Sbjct: 235 VDSCVETGASGIIATNTTIARPTGLSGVHAGEVGGLSGGPLFAASTGILAEVARLSQNRL 294 Query: 291 PIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIV 333 +IGVGG+ S A KI GA +VQ+Y+G +GP L I+ Sbjct: 295 ALIGVGGVSSGWQAYAKILVGADMVQLYTGLALEGPHLPNRIL 337 >UniRef50_Q0J918 Os04g0676300 protein n=1 Tax=Oryza sativa Japonica Group RepID=Q0J918_ORYSJ Length = 601 Score = 223 bits (568), Expect = 8e-57, Method: Compositional matrix adjust. Identities = 132/349 (37%), Positives = 193/349 (55%), Gaps = 37/349 (10%) Query: 13 LDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPV---NCMGLTFKNPLGLAAGLDKDGE 69 LD E AH +T + R+K P V G F NP+GLAAG DK+ E Sbjct: 188 LDAEFAHRLA------VTAASHGFVPREKRPDPSVLGLEIWGRKFTNPIGLAAGFDKNAE 241 Query: 70 CIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKK 129 ++ L MGFG +E+G+VTP PQ GN KPR+FRL + +INR GFN+ G+ + + + Sbjct: 242 AVEGLLGMGFGFVEVGSVTPLPQEGNPKPRIFRLREHGAVINRCGFNSEGIVVVAKRLGA 301 Query: 130 AHYD-------------------------GVLGINIGKNKDTPVEQGKDDYLICMEKIYA 164 H G+LG+N+GKNK + E DY+ + + Sbjct: 302 QHGKRKMEETSSSTSPTTSDVKQGGKAGPGILGVNLGKNKIS--EDATADYVQGVHTLSQ 359 Query: 165 YAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSE 224 YA Y+ IN+SSPNTPGLR LQ + L DL+ ++ ++++Q P+ VKIAPDLS+ Sbjct: 360 YADYLVINVSSPNTPGLRKLQGRKQLKDLVKKVQAARDEMQWAEDGPPPLLVKIAPDLSK 419 Query: 225 EELIQVADSLVRHNIDGVIATNTTLDR-SLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLS 283 ++L +A + +DG+I +NTT+ R S + GGLSG+PL ST ++R + Sbjct: 420 QDLEDIAAVALALRLDGLIISNTTISRPSPADTHPLAQEAGGLSGKPLFDLSTNVLREMY 479 Query: 284 LELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 + G++P+IG GG+ S A +KI +GA+LVQ+Y+ F + GP LI I Sbjct: 480 ILTRGKIPLIGCGGVSSGEDAYKKIRSGATLVQLYTAFAYGGPALIPRI 528 >UniRef50_B3DX48 Dihydroorotate dehydrogenase n=1 Tax=Methylacidiphilum infernorum V4 RepID=PYRD_METI4 Length = 348 Score = 223 bits (568), Expect = 8e-57, Method: Compositional matrix adjust. Identities = 133/333 (39%), Positives = 186/333 (55%), Gaps = 19/333 (5%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALV---RQKVPAKPVNCMGLTFKNP 57 +Y F+R LF L+PE AH L F L+ ++ +P P G+ F NP Sbjct: 2 IYKSFLRPILFSLEPEYAHNLCLGLLSHPFYPFFHKLLASFQKDLPLLPKELWGMQFPNP 61 Query: 58 LGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNN 117 +GLAAG DK+G + A + GFG +EIGTVTP PQ GN PRL RL L N +GF + Sbjct: 62 VGLAAGFDKNGVGLRAWESFGFGFVEIGTVTPLPQEGNPAPRLCRLPKEGALWNSLGFPS 121 Query: 118 LGVDNLVENVKKAHYDG----VLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINI 173 G + E +KK G +GINIGKN+ TP+E+ +DY C + +N+ Sbjct: 122 QGAQRVAERLKKVFLSGRPKIPVGINIGKNRHTPLEETIEDYKKCFSYFKDLGDFFVVNV 181 Query: 174 SSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADS 233 SSPNTPGL++LQ L+ L ++ N L + K P+ VKIAPD+ + L + + Sbjct: 182 SSPNTPGLKSLQQKRFLELLF----DRLNPLNSSPRK--PLLVKIAPDIELKNLAGILEV 235 Query: 234 LVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPII 293 L+R+ G++ NT + + GGLSG+PL+ S +IR + E GRLPII Sbjct: 236 LLRNESVGIVIANT------LPAKGPGGKEGGLSGKPLRELSLGLIRFVKKETAGRLPII 289 Query: 294 GVGGIDSVIAAREKIAAGASLVQIYSGFIFKGP 326 GVGGI S A EK+ AGA L++I++GF++ GP Sbjct: 290 GVGGIFSSKDAFEKMEAGADLIEIFTGFVYNGP 322 >UniRef50_Q7RLG4 Dihydroorotate dehydrogenase, putative n=2 Tax=Plasmodium (Vinckeia) RepID=Q7RLG4_PLAYO Length = 512 Score = 221 bits (564), Expect = 2e-56, Method: Compositional matrix adjust. Identities = 140/345 (40%), Positives = 199/345 (57%), Gaps = 27/345 (7%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 MY F+ L +D E H+ F L + P++ V A + L F NP G+ Sbjct: 136 MYDVFLDLCLKYVDSEVCHDL-FLLLGKYGLLPYDT-SNDSVYATS-DIKNLNFINPFGV 192 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAG DK+G CID++ +GF IEIGT+TP+PQ GNDKPR+FR V+ + +IN GFNN+G Sbjct: 193 AAGFDKNGICIDSILKLGFSFIEIGTITPKPQKGNDKPRIFRDVENKSIINACGFNNIGC 252 Query: 121 DNLVENV----KKAHYDGVL-----GINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAI 171 D + EN+ KK D +L G++IGKNK T E DD + KI YA YIAI Sbjct: 253 DKVTENLISFRKKQEEDKLLSKHIVGVSIGKNKYT--ENIVDDLKYSIYKIARYADYIAI 310 Query: 172 NISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHH----------KYVPIA-VKIAP 220 N+SSPNTPGLR Q L +++ +K + N ++ H K P+ VK+AP Sbjct: 311 NVSSPNTPGLRDNQESNKLKNIILFVKQEINKIEESGHNGENFWMNTTKKKPLVFVKLAP 370 Query: 221 DLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIR 280 DL E ++A L+ IDG+I +NTT+++ ++ + D+ GG+SG+ L+ ST +I Sbjct: 371 DLENSEKKKIAQVLLDTGIDGMIISNTTINKMDIKSFE--DKKGGVSGKKLKDLSTNLIS 428 Query: 281 RLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKG 325 + + N ++PII GGI + A EKI AGAS+ Q+YS +F G Sbjct: 429 DMYIYTNKQIPIIASGGILTGADALEKIEAGASVCQLYSCLVFNG 473 >UniRef50_Q7U3U2 Dihydroorotate dehydrogenase n=30 Tax=cellular organisms RepID=PYRD_SYNPX Length = 396 Score = 220 bits (561), Expect = 5e-56, Method: Compositional matrix adjust. Identities = 128/300 (42%), Positives = 171/300 (57%), Gaps = 21/300 (7%) Query: 50 MGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGL 109 G F NP+GLAAG DK+G GFG E+GTVT QPGN +PRLFRL + Sbjct: 74 FGCRFPNPVGLAAGFDKNGVAAGLWDRFGFGFAEVGTVTWHGQPGNPRPRLFRLAQEQAA 133 Query: 110 INRMGFNNLGVDNLVENVKK------AHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIY 163 +NRMGFNN G L +++ VLGIN+GK+K T +EQ +DY +E + Sbjct: 134 LNRMGFNNDGAQALRRTLERQRLAPPGRRPAVLGINVGKSKVTALEQAPEDYASSLELLA 193 Query: 164 AYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLS 223 A Y IN+SSPNTPGLR LQ ++ + + P+ VKIAPDL Sbjct: 194 PLADYAVINVSSPNTPGLRDLQD--------SSQLRRLVERLRRLPACPPLLVKIAPDLE 245 Query: 224 EEELIQVADSLVRHNIDGVIATNTTLDR------SLVQ-GMKNCDQTGGLSGRPLQLKST 276 +E + +A + GVIA NT+LDR L+Q G ++ GGLSG PL+ ++ Sbjct: 246 DEAIDGIARLAFEEGLAGVIAVNTSLDRLGLEQRRLLQTGRTLAEEAGGLSGAPLRQRAL 305 Query: 277 EIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 E+IRRL L +IGVGGIDS A E+I AGASL+Q+Y+G+IF+GP L+ I+ + Sbjct: 306 EVIRRLRASAGPALTLIGVGGIDSAEIAWERITAGASLIQLYTGWIFQGPELVPRILEGL 365 >UniRef50_B3L830 Dihydroorotate dehydrogenase, putative n=1 Tax=Plasmodium knowlesi strain H RepID=B3L830_PLAKH Length = 556 Score = 219 bits (558), Expect = 1e-55, Method: Compositional matrix adjust. Identities = 134/350 (38%), Positives = 198/350 (56%), Gaps = 32/350 (9%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 +Y F++ L +D E H+ F + + P++ + GL F NP G+ Sbjct: 179 LYDIFLKFLLKYVDGEMCHDL-FLLMGKYNMLPYDTSKDSIYSCTGIG--GLNFINPFGV 235 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAG DK+G CID + +GF IE+GT+TP+PQ GNDKPR+FR V+ +IN GFNN+G Sbjct: 236 AAGFDKNGVCIDGILKLGFSFIEVGTITPKPQKGNDKPRIFRDVETRSIINCCGFNNIGC 295 Query: 121 DNLVENVK----KAHYDGVL-----GINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAI 171 D + EN+K K D +L G+++GKNKD+ +D C+ +I YA YIAI Sbjct: 296 DEVTENLKRFREKQKTDKLLHRHFVGVSLGKNKDSA--DILEDLSYCISRIGKYADYIAI 353 Query: 172 NISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMH---------------HKYVPIA- 215 N+SSPNTPGLR Q E L ++ +K + + L+ + K P+ Sbjct: 354 NVSSPNTPGLRDNQQSERLQRIILRVKEEVDKLEESNVVGDDVVRGDTWVNTSKRKPLVF 413 Query: 216 VKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKS 275 VK+APDL E E ++AD L++ +DG+I NTT ++ ++ + D+ GG+SG L+ S Sbjct: 414 VKLAPDLEEGEKKKIADVLLKTKVDGMIICNTTTEKFNIKNFQ--DKKGGVSGEKLKDVS 471 Query: 276 TEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKG 325 T+ I ++ N ++PII GGI + A EKI AGAS+ Q+YS +F G Sbjct: 472 TKFISQMYNYTNKKIPIIASGGIFTGKDALEKIEAGASVCQLYSCLVFNG 521 >UniRef50_Q75CE1 Dihydroorotate dehydrogenase, mitochondrial n=9 Tax=Saccharomycetales RepID=PYRD_ASHGO Length = 444 Score = 218 bits (556), Expect = 2e-55, Method: Compositional matrix adjust. Identities = 149/363 (41%), Positives = 204/363 (56%), Gaps = 46/363 (12%) Query: 4 PFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAAG 63 P VR L D E H+ L+ G + + + P V G T NP+G AAG Sbjct: 70 PLVR--LVTPDAEDGHKLGIWFLK--YGLAPKLMFDKDDPVLKVEVFGKTMSNPIGCAAG 125 Query: 64 LDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLG---- 119 LDKDGE ID + GFG +EIGTVTP QPGN KPR FRL E +INR GFN+ G Sbjct: 126 LDKDGEAIDGIAQSGFGYVEIGTVTPLAQPGNPKPRFFRLPMDEAVINRYGFNSSGHKKV 185 Query: 120 VDNLVENVKK---AHY------------DGVLGINIGKNKDTPVEQGKDDYLICMEKIYA 164 DN++ V++ A++ D +LGIN+GKNK+ +DYL +EK + Sbjct: 186 YDNVLSRVRQFLGAYFRDDTVNSLALYKDKLLGINLGKNKNG---DEVEDYLRGVEKFQS 242 Query: 165 YAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQND-------LQAMHHKYVPIAVK 217 A + IN+SSPNTPGLR LQ L +LL+ I K+N L A HK P+ VK Sbjct: 243 LADVLVINVSSPNTPGLRDLQQEGRLTELLSMIVAKRNSLINEGNVLGASTHK-PPVLVK 301 Query: 218 IAPDLSEEELIQVADSLVRHNIDGVIATNTTLDR-----SLVQGMKNCDQTGGLSGRPLQ 272 IAPDL+E EL +A++ + +IDG+I +NTT+ R ++ + +KN Q GGLSG+P++ Sbjct: 302 IAPDLTEPELQSIAEAAKKSSIDGIIVSNTTIQRPDSLYTVDEELKN--QAGGLSGKPVK 359 Query: 273 ---LKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLI 329 LK+ I + + + N L ++G GGI S A E AGA VQ+Y+ + ++GP LI Sbjct: 360 PFALKALRTIHQYTKDTN--LVLVGCGGISSGQDAIEFAKAGAHFVQLYTAYAYRGPGLI 417 Query: 330 KEI 332 I Sbjct: 418 ARI 420 >UniRef50_D1B1W1 Dihydroorotate dehydrogenase n=2 Tax=Campylobacteraceae RepID=D1B1W1_SULD5 Length = 355 Score = 218 bits (555), Expect = 2e-55, Method: Compositional matrix adjust. Identities = 130/342 (38%), Positives = 183/342 (53%), Gaps = 29/342 (8%) Query: 3 YPFVRKALFQLDPERAH---EFTFQQLRRITGTPFEALVRQKVPAKPV--------NCMG 51 Y ++K +F PE AH EF F+ G + + + + Sbjct: 6 YGLMKKIMFNFSPETAHNIAEFFFKH-----GANYAPFILAPLAERFFIHDKRLEQTLFD 60 Query: 52 LTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLIN 111 TF NP+GLAAG DK+ I L A+GFG IE GT+TP PQ GN KPR FR + E + N Sbjct: 61 RTFHNPIGLAAGFDKNATMIKMLTALGFGHIEYGTMTPEPQSGNAKPRCFRFPEEESIQN 120 Query: 112 RMGFNNLGVDNLVENVKKAH-YDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIA 170 MGFNN G+ + + ++ + + L NIGKNK T E DY +++ + ++ Sbjct: 121 AMGFNNEGMHKIAKRLESLYPFATPLAANIGKNKITSAENALKDYEKLIKRFKDVSDFLV 180 Query: 171 INISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQV 230 +NISSPNTPGLR LQ + +L + A P+ +KIAPDL +E I++ Sbjct: 181 VNISSPNTPGLRDLQNEAFIKELF---------MMAKELTCKPVLLKIAPDLEIKEAIEL 231 Query: 231 ADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRL 290 + + G++ATNTT+D SL + N GG+SG+ L KS + ++ E G+ Sbjct: 232 CSCALENGAKGIVATNTTIDYSL---LPNAKDFGGISGKVLCEKSFRMFEGIAKEFFGKT 288 Query: 291 PIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 +I VGGIDS A ++ AGASL+QIYS FIFKGP L + I Sbjct: 289 TLISVGGIDSAEEAYRRLKAGASLLQIYSAFIFKGPSLNRTI 330 >UniRef50_Q2YWG7 Dihydroorotate dehydrogenase n=56 Tax=Staphylococcus RepID=Q2YWG7_STAAB Length = 354 Score = 218 bits (554), Expect = 3e-55, Method: Compositional matrix adjust. Identities = 121/335 (36%), Positives = 186/335 (55%), Gaps = 11/335 (3%) Query: 3 YPFVRKALFQLDPERAHEFTFQQLRRITGTPF-----EALVRQKVPAKPVNCMGLTFKNP 57 Y ++ LF+++PE+AH T L+ + P + L K P G T+ NP Sbjct: 2 YKLIKPFLFKIEPEKAHGLTIDALKTLQKFPVLFPVVDKLFTYKNPTLSQTIQGNTYDNP 61 Query: 58 LGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNN 117 +GLAAG DK E AL +GFG++E+G +TP+PQPGN +PR+FRL++ + LINRMGFNN Sbjct: 62 IGLAAGFDKSCEVPKALEHLGFGALELGGITPKPQPGNPQPRMFRLLEDDALINRMGFNN 121 Query: 118 LGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPN 177 +G++ + +++K Y +GIN+G NK TP E DY+ ++ + +NISSPN Sbjct: 122 IGMNKALSHLRKNAYQVPVGINVGVNKMTPYEARYQDYIKVIDTFKHDVSFFTVNISSPN 181 Query: 178 TPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRH 237 T L+ + L A+ + H VPI +K+ D+ + L + ++ Sbjct: 182 TENLQNFHDKDEFSMLCQALTT----FKKQHDVTVPIYLKLTSDMDFDGLKALLPAITE- 236 Query: 238 NIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGG 297 DG+I NTT R + ++ GGLSGRPL ++ ++I+ + NG IIG GG Sbjct: 237 TFDGIILANTTRQRDGLTSANKVEE-GGLSGRPLFERNLKLIKYAYQQTNGEFLIIGTGG 295 Query: 298 IDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 + S A + + GASL+QIYS + +GP L K++ Sbjct: 296 VFSTEDAIKMMRHGASLIQIYSSLVIEGPGLTKKM 330 >UniRef50_P32747 Dihydroorotate dehydrogenase, mitochondrial n=2 Tax=Schizosaccharomyces RepID=PYRD_SCHPO Length = 443 Score = 216 bits (551), Expect = 7e-55, Method: Compositional matrix adjust. Identities = 132/330 (40%), Positives = 181/330 (54%), Gaps = 42/330 (12%) Query: 43 PAKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFR 102 P+ V G F NP+GLAAG DK + I L GF +EIG+VTP+PQPGN KPR FR Sbjct: 103 PSLAVEVWGKKFCNPIGLAAGFDKQADAISGLLNFGFSYLEIGSVTPKPQPGNPKPRYFR 162 Query: 103 LVDAEGLINRMGFNNLGVDNLVENVKK--------------AHYDG-------------- 134 L +INR GFN++G D ++ ++K +D Sbjct: 163 LKPDLSVINRYGFNSIGHDAILAKIQKRVRKYIAKTSPQLLKQFDANPASCTDPAVLGVP 222 Query: 135 -------VLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYG 187 LGIN+GKNK+ +DY+ + +A + IN+SSPNTPGLR LQ Sbjct: 223 RSLIPNKFLGINLGKNKNG---NEIEDYVEGVRTFGNFADILVINVSSPNTPGLRNLQKK 279 Query: 188 EALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNT 247 AL LLTA+ +++N L + H P+ VKIAPDL+EEEL +AD L + IDGVI NT Sbjct: 280 SALSTLLTAVVSERNKLNSPHP---PVLVKIAPDLNEEELTDIADVLKKCKIDGVIVGNT 336 Query: 248 TLDR-SLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAARE 306 T+ R ++ + ++TGGLSG PL+ + +R L L+ +PIIG GGI S A E Sbjct: 337 TVQRPKTLKSTSHVEETGGLSGPPLKPIALNTLRTLRKHLSSDIPIIGCGGISSGKDAIE 396 Query: 307 KIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 AGA++VQ+Y+ + GP + +I I Sbjct: 397 YARAGATMVQVYTALGYDGPVIAHKIKQEI 426 >UniRef50_A9HBE5 Dihydroorotate oxidase n=10 Tax=Acetobacteraceae RepID=A9HBE5_GLUDA Length = 357 Score = 215 bits (548), Expect = 1e-54, Method: Compositional matrix adjust. Identities = 129/342 (37%), Positives = 188/342 (54%), Gaps = 25/342 (7%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 M P VR+ LDPE AH L G + Q PA V +GL F NP+G+ Sbjct: 8 MLMPLVRR----LDPEDAHRLGLNALLLGLGG--GSGSGQDDPALAVRALGLRFPNPIGI 61 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAG DK+ + L +GFG +E GTVTPRPQPGN +PRLFRL + +INRMGFNN G+ Sbjct: 62 AAGFDKNALVVRPLARIGFGFVEAGTVTPRPQPGNPRPRLFRLDEDRAIINRMGFNNQGI 121 Query: 121 DNLVENVKKAH-------YDGV---LGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIA 170 D + + H + G +G N+G NK + DY + ++ YA Y+ Sbjct: 122 DRFAVRLARLHRVSPAGRHAGARVPVGANLGINKFG--ADPERDYPRLVGRVKHYADYVV 179 Query: 171 INISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQV 230 +N+SSPNTPGLR LQ L LL AI H P+ VK++PDL+ +++ + Sbjct: 180 LNLSSPNTPGLRDLQEASRLGALLQAIGEA-------HPDRPPLLVKLSPDLARDDIGPI 232 Query: 231 ADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRL 290 ++ + G+I TNTT+ R + + GGLSGRPL+ + +I R ++ GRL Sbjct: 233 VEAAIAGGAQGLIVTNTTISRPAGLRSPHAGEAGGLSGRPLRPLAADIFRAVAQVAAGRL 292 Query: 291 PIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 ++ GGI++ +++ AGA LVQ+YS F ++GP +++ + Sbjct: 293 ALVACGGIETGADIVDRVRAGADLVQLYSAFAYEGPGIVRRL 334 >UniRef50_C7NF21 Dihydroorotate oxidase A n=1 Tax=Kytococcus sedentarius DSM 20547 RepID=C7NF21_KYTSD Length = 385 Score = 215 bits (547), Expect = 2e-54, Method: Compositional matrix adjust. Identities = 132/353 (37%), Positives = 190/353 (53%), Gaps = 22/353 (6%) Query: 2 YYPFVRKALFQL---DPERAHEFTFQQLRRITGTP-----FEALVRQKVPAKP----VNC 49 Y R LF+L D E AH T Q P A P +P V C Sbjct: 33 YEHLARPVLFRLGGGDAETAHHTTLQGAAAAARVPGLLHLVAAATGGLAPGQPAGGRVVC 92 Query: 50 MGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGL 109 G+ F + +GLAAG+DKDG + A+G G +E+GTVTPRPQ GN +PR+ RL + + Sbjct: 93 AGVAFGHRVGLAAGVDKDGTALLTWQALGLGHVELGTVTPRPQHGNPRPRVHRLRASRAV 152 Query: 110 INRMGFNNLGVDNLVENVKKAHYDGV---LGINIGKNKDTPVEQGKDDYLICMEKIYAYA 166 +N MGF N GV+ V ++ A +G+ +G++IGKNKDTP+ + +DY C+ Sbjct: 153 LNAMGFPNAGVEAAVHRLRVARDEGLTIPVGLSIGKNKDTPLARALEDYAACVRVAAGLP 212 Query: 167 GYIAINISSPNTPGLRTLQYGEALDDLLTA-IKNKQNDLQAMHHKYVPIAVKIAPDLSEE 225 Y+A+NISSPNTPGLR L E L LL + ++ A VP+ K+APD+ + Sbjct: 213 DYLAVNISSPNTPGLRGLADPEPLRALLAGVVAAERERADAAGTPPVPVLCKVAPDMDDA 272 Query: 226 ELIQVADSLVRHNIDGVIATNTTLDRSLV----QGMKNCDQTGGLSGRPLQLKSTEIIRR 281 L + G+IATNTTL R + + ++ GG+SG PL ++ E++R Sbjct: 273 ALHAAVGIAQEEGVAGIIATNTTLRRDGLTAEDRAWVGPERPGGVSGAPLTDRAREVVRL 332 Query: 282 LSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVT 334 + + LP++GVGG+ + E + AGA LVQ+Y+GFI+ GP L+ I Sbjct: 333 VRAGCD--LPVVGVGGVMTPQDGVELVRAGADLVQVYTGFIYAGPALVAGIAA 383 >UniRef50_Q0GF37 Dihydroorotate dehydrogenase n=2 Tax=Ustilago maydis RepID=Q0GF37_USTMA Length = 677 Score = 214 bits (546), Expect = 2e-54, Method: Compositional matrix adjust. Identities = 142/394 (36%), Positives = 203/394 (51%), Gaps = 74/394 (18%) Query: 2 YYPFVRKALFQ----------LDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMG 51 YY R A+ + LDPE A + + L TG LV + G Sbjct: 90 YYADSRSAIHRWIAVPALKAFLDPESAQKLAVKMLE--TGLAPRDLVDDDAVLE-TELFG 146 Query: 52 LTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLIN 111 NP+GLAAG DK E ID L +GFG IEIG+VTP PQPGN +PR FRL++ IN Sbjct: 147 RKLSNPIGLAAGFDKQAEAIDGLLDLGFGFIEIGSVTPEPQPGNPQPRYFRLIEDNACIN 206 Query: 112 RMGFN----NLGVDNLVENVKKA--HYDGV------------------------------ 135 R GFN N+ + L + +++ H V Sbjct: 207 RFGFNSEGHNVILSRLRDRIRRWLLHSSSVANLQDALLASPDSASVNARQLIATHPKSTS 266 Query: 136 -----------------LGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNT 178 LGIN+GKNK T E+ DDY+ +E++ YA I +N+SSPNT Sbjct: 267 AFVDATDLPRSLRPAKMLGINLGKNK-TSNEESVDDYVKGVERLGPYADMIIVNVSSPNT 325 Query: 179 PGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKY------VPIAVKIAPDLSEEELIQVAD 232 PGLR LQ L+DLLT + ++ + H ++ VP+ VKIAPDLSEEEL VAD Sbjct: 326 PGLRRLQRRGVLEDLLTQVVRARDGMVESHLRFSDKKVAVPLLVKIAPDLSEEELHDVAD 385 Query: 233 SLVRHNIDGVIATNTTLDR-SLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLP 291 + ++ IDG++ +NTT+ R + ++ ++ +TGGLSG P++ + + + + L G+LP Sbjct: 386 AALKSGIDGLVISNTTISRPASLRSSEHVRETGGLSGAPVKPLALKALTTVHKRLQGKLP 445 Query: 292 IIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKG 325 IIG GGI + A + AGAS +++Y+ F ++G Sbjct: 446 IIGCGGISNGQDALDYAKAGASAIELYTSFGYQG 479 >UniRef50_B0CUF5 Predicted protein n=4 Tax=Dikarya RepID=B0CUF5_LACBS Length = 499 Score = 214 bits (544), Expect = 4e-54, Method: Compositional matrix adjust. Identities = 131/348 (37%), Positives = 194/348 (55%), Gaps = 38/348 (10%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPV------NC--MGL 52 ++ P +R F LD E H+F + LR +G P PV NC G Sbjct: 71 IFTPILR---FALDAETGHKFAVKVLR--SGL---------APKDPVLDDARLNCQIWGQ 116 Query: 53 TFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINR 112 NP+GLAAG DKDGE ID L +GF +EIG+VTP+PQPGN +PR+F L + LINR Sbjct: 117 EASNPVGLAAGFDKDGEAIDGLFELGFSWVEIGSVTPKPQPGNPRPRVFHLPEDSSLINR 176 Query: 113 MGFNNLGVDNLVENVKK------------AHYDG-VLGINIGKNKDTPVEQGKDDYLICM 159 GF + G +++ ++ + +G +L +N+GKNK++P + DD++ + Sbjct: 177 YGFPSQGHASVLSRIRSRIPPFTSGPNRASLREGCLLAVNLGKNKESPADS-IDDFVTGV 235 Query: 160 EKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQ--AMHHKYVPIAVK 217 Y+ + +N+SSPNTPGLR LQ + L+ LL + +++L + + + +K Sbjct: 236 RTFGPYSDVLVVNVSSPNTPGLRGLQNRDVLERLLDGVTKARDELSPSVLTFRKPKLVLK 295 Query: 218 IAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTE 277 APDL+E EL +AD + +IDGVI +NTT+ R N + GGLSG P++ S + Sbjct: 296 FAPDLNESELADIADVIRNSSIDGVIVSNTTVQRPKSLVNPNKSEMGGLSGPPVKPLSLK 355 Query: 278 IIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKG 325 +R L L +P+IG GGI + A E AGAS+VQ+Y+GF + G Sbjct: 356 ALRILRGHLPASIPLIGCGGISTGADALEFAKAGASMVQVYTGFGYDG 403 >UniRef50_Q5HL43 Dihydroorotate dehydrogenase n=8 Tax=Staphylococcus RepID=Q5HL43_STAEQ Length = 354 Score = 213 bits (542), Expect = 8e-54, Method: Compositional matrix adjust. Identities = 126/339 (37%), Positives = 189/339 (55%), Gaps = 11/339 (3%) Query: 3 YPFVRKALFQLDPERAHEFTFQQLRRITG-TPFEALVRQ----KVPAKPVNCMGLTFKNP 57 Y V+ LF+LDPERAH T L+ + +P +V + P + G++F NP Sbjct: 2 YKLVKPLLFKLDPERAHGLTINALKCVQKCSPILPIVNKLFTYNNPILTQHIHGISFDNP 61 Query: 58 LGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNN 117 +GLAAG DK E AL +GFG+IE+G +TP+PQPGN KPR++RL++ + LINRMGFNN Sbjct: 62 IGLAAGFDKSCEVPKALENIGFGAIELGGITPKPQPGNPKPRMYRLLEDDALINRMGFNN 121 Query: 118 LGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPN 177 G++ + N++ +G+N+G NK T E DY+ ++ + +NISSPN Sbjct: 122 KGMNKALSNLRNHSCSIPVGLNVGVNKTTSYENRYQDYIKVIDTFKNDVSFFTVNISSPN 181 Query: 178 TPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRH 237 T L+ + L A+ N +A ++ VPI +K+ D+ + ++ S + Sbjct: 182 TENLQNFHDEDEFSMLCDAL----NSFKAKNNINVPIFLKLTSDMELDGFKKILPS-ITD 236 Query: 238 NIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGG 297 DGV+ NTT R + KN Q GGLSGRPL ++ ++++ + G IIG GG Sbjct: 237 TFDGVMLANTTRQRDGLNS-KNKIQEGGLSGRPLFQRNLQLVKYAYQQTRGNFLIIGTGG 295 Query: 298 IDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 I S A + + GASL+QIYS + +GP L K++ I Sbjct: 296 IFSSEDAIKMLRNGASLLQIYSSLVIEGPGLTKKMNKEI 334 >UniRef50_Q2GEM2 Dihydroorotate dehydrogenase n=2 Tax=Neorickettsia RepID=Q2GEM2_NEOSM Length = 348 Score = 213 bits (541), Expect = 1e-53, Method: Compositional matrix adjust. Identities = 134/338 (39%), Positives = 187/338 (55%), Gaps = 20/338 (5%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPV---NCMGLTFKNP 57 M+ + L +L+P AH+ T R+ F V Q P+ GL FKNP Sbjct: 1 MHEKLLVALLQRLNPSFAHDVT-----RVVLKHFPGFVSQNSFEDPILESRVCGLHFKNP 55 Query: 58 LGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNN 117 +G+AAG DK+ EC+ AL +GFG IE+GTVT +PQ GN PRLFRL +INR+GFNN Sbjct: 56 IGIAAGFDKNAECVTALRRVGFGFIELGTVTLKPQKGNPSPRLFRLPQDGAIINRLGFNN 115 Query: 118 LGVDNLVENVKKA--HYD-GVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINIS 174 G+ ++++KKA H D LG+NIGKN + DY + + A YI +NIS Sbjct: 116 KGIAYFLKSLKKAMTHMDLPPLGVNIGKNAVS--SNAVSDYARLAAYVSSVADYITLNIS 173 Query: 175 SPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSL 234 SPNT LR +Q E L++LL A+K A V I +K+APDL+E + + Sbjct: 174 SPNTVSLRDMQKVEILEELLIAVK-------AAVGSNVRIFIKVAPDLAEGAEVGIISLA 226 Query: 235 VRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIG 294 ++H + G+I +NTT+ K+ + GGLSG PL ST ++R++ NG L IG Sbjct: 227 LKHKVAGIIVSNTTIGCRESLHSKHKVEYGGLSGTPLFKLSTGLLRKMYRCTNGELVFIG 286 Query: 295 VGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 GGI A KI GA+L+Q Y+ F + G L+ +I Sbjct: 287 CGGISDAETAYAKIRNGAALIQAYTSFTYHGFGLLNQI 324 >UniRef50_Q08210 Dihydroorotate dehydrogenase homolog, mitochondrial n=4 Tax=Plasmodium RepID=PYRD_PLAF7 Length = 569 Score = 211 bits (537), Expect = 3e-53, Method: Compositional matrix adjust. Identities = 141/376 (37%), Positives = 198/376 (52%), Gaps = 58/376 (15%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 +Y F++ L +D E H+ F L + P++ N L F NP G+ Sbjct: 167 LYDIFLKFCLKYIDGEICHDL-FLLLGKYNILPYDT--SNDSIYACTNIKHLDFINPFGV 223 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAG DK+G CID++ +GF IEIGT+TPR Q GN KPR+FR V++ +IN GFNN+G Sbjct: 224 AAGFDKNGVCIDSILKLGFSFIEIGTITPRGQTGNAKPRIFRDVESRSIINSCGFNNMGC 283 Query: 121 DNLVENV----KKAHYDGVL-----GINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAI 171 D + EN+ K+ D +L G++IGKNKDT DD C+ KI YA YIAI Sbjct: 284 DKVTENLILFRKRQEEDKLLSKHIVGVSIGKNKDTV--NIVDDLKYCINKIGRYADYIAI 341 Query: 172 NISSPNTPGLRTLQYGEALDDLLTAIKN-------------------------------- 199 N+SSPNTPGLR Q L +++ ++K Sbjct: 342 NVSSPNTPGLRDNQEAGKLKNIILSVKEEIDNLEKNNIMNDESTYNEDNKIVEKKNNFNK 401 Query: 200 ---------KQNDLQAMHHKYVPIA-VKIAPDLSEEELIQVADSLVRHNIDGVIATNTTL 249 K N L K P+ VK+APDL++E+ ++AD L+ NIDG+I +NTT Sbjct: 402 NNSHMMKDAKDNFLWFNTTKKKPLVFVKLAPDLNQEQKKEIADVLLETNIDGMIISNTTT 461 Query: 250 DRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIA 309 + ++ +N + GG+SG L+ ST+ I + N ++PII GGI S + A EKI Sbjct: 462 QINDIKSFEN--KKGGVSGAKLKDISTKFICEMYNYTNKQIPIIASGGIFSGLDALEKIE 519 Query: 310 AGASLVQIYSGFIFKG 325 AGAS+ Q+YS +F G Sbjct: 520 AGASVCQLYSCLVFNG 535 >UniRef50_A7BDH3 Putative uncharacterized protein n=1 Tax=Actinomyces odontolyticus ATCC 17982 RepID=A7BDH3_9ACTO Length = 312 Score = 211 bits (537), Expect = 3e-53, Method: Compositional matrix adjust. Identities = 116/280 (41%), Positives = 168/280 (60%), Gaps = 15/280 (5%) Query: 58 LGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNN 117 LGLAAG+DKD E + + A+G+ +EIGTVTPRPQPGND PRL+RL++ GL NRMGFNN Sbjct: 36 LGLAAGMDKDAEAVLGMCALGYAFVEIGTVTPRPQPGNDAPRLWRLMEERGLRNRMGFNN 95 Query: 118 LGVDNLVENVKK-----AHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAIN 172 G D E +++ A ++G NIGKNK T DY C + + ++ +N Sbjct: 96 AGADAAAEKLRELRSTPAGRATIVGANIGKNKVTSEADAPADYEYCARTLAHWVDFVVVN 155 Query: 173 ISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVAD 232 +SSPNTPGLR LQ + L +L A + + +P+ VKIAPDL++E+++ V + Sbjct: 156 VSSPNTPGLRDLQSVDHLRPILQAARRGCE--AGAPDRTMPLFVKIAPDLADEDIVAVVE 213 Query: 233 SLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPI 292 + GV+ATNTT++ +L + GG+SG PL ++ E++ ++ L+ + Sbjct: 214 LTKELGLAGVVATNTTINHNLGE--------GGVSGAPLLPRALEVVSLVARHLDDDQIL 265 Query: 293 IGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 IG GGI S A I+AGA LV+ +S FIF+GP E+ Sbjct: 266 IGTGGISSPEDALRMISAGADLVEAFSAFIFEGPSWPGEV 305 >UniRef50_C2BWU0 Possible dihydroorotate oxidase n=3 Tax=Mobiluncus RepID=C2BWU0_9ACTO Length = 348 Score = 210 bits (535), Expect = 5e-53, Method: Compositional matrix adjust. Identities = 138/346 (39%), Positives = 191/346 (55%), Gaps = 34/346 (9%) Query: 3 YPFVRKALF-QLDPERAH-------EF------TFQQLRRIT--GTPF--EALVRQKVPA 44 Y FV + LF +LD E H EF T Q RI G P L R + Sbjct: 2 YKFVFRHLFVKLDAEWVHRRAIDWLEFWGRFGLTRQVAARIVHRGEPTFTWPLPRPNFDS 61 Query: 45 KPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLV 104 P T+ PLGLAAG+DK+ I A+GFG +EIGT+TP PQPGND+PRL+R+ Sbjct: 62 APAGTKFRTY-GPLGLAAGMDKEARAIAMWDALGFGFMEIGTITPLPQPGNDRPRLWRIP 120 Query: 105 DAEGLINRMGFNNLGVDNLVENVKKAHYDG----VLGINIGKNKDTPVEQGKDDYLICME 160 L N MGFNN G +++ + ++G NIGKNK TP E+ DY Sbjct: 121 QQRALRNAMGFNNEGARAAARRLRRWRAEYGERIIIGANIGKNKVTPPEKAPADYRKVTR 180 Query: 161 KIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAP 220 + A ++ IN+SSPNTPGLR LQ A+ LL +K Q +L++ +P+ VKIAP Sbjct: 181 VLAALVDFLVINVSSPNTPGLRDLQ---AVSSLLPIVKAVQRELESQGLSELPVFVKIAP 237 Query: 221 DLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIR 280 DL +E++ VA + + GV+ATNTT+ L GG+SG PL+ ++ E+++ Sbjct: 238 DLVDEDIAAVAQLTMDEGLTGVVATNTTIKHDL--------GAGGMSGEPLRNRALEVVK 289 Query: 281 RLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGP 326 L L+ IIGVGGI + AR +AAGA+L++ +S FI++GP Sbjct: 290 LLREHLSPEKTIIGVGGITTPEDARAMLAAGANLIEGFSAFIYEGP 335 >UniRef50_Q6SZS6 Dihydroorotate dehydrogenase, mitochondrial n=10 Tax=Saccharomycetales RepID=PYRD2_KLUMA Length = 446 Score = 210 bits (534), Expect = 7e-53, Method: Compositional matrix adjust. Identities = 137/322 (42%), Positives = 191/322 (59%), Gaps = 36/322 (11%) Query: 47 VNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDA 106 VN G T NP+G AAGLDKDGE ID + A GFG +EIG+VTP PQPGN KPR FRL Sbjct: 109 VNVFGKTLTNPVGCAAGLDKDGEAIDGIFAGGFGYVEIGSVTPLPQPGNPKPRFFRLPMD 168 Query: 107 EGLINRMGFNNLGVDNLVENVK---------------------KAHYDGVLGINIGKNKD 145 E +INR GFN+ G D++V+N++ + + +LGIN+GKNK+ Sbjct: 169 EAVINRYGFNSSGHDSVVKNLQNRVSRFINSYFCNDINAVDNLSLYQNKLLGINLGKNKN 228 Query: 146 TPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQ---- 201 Q DYL +EK YA + IN+SSPNTPGLR LQ L +LL+ + K+ Sbjct: 229 GDEVQ---DYLKGVEKFQKYADVLVINVSSPNTPGLRGLQKESILTNLLSQVVAKRDSLV 285 Query: 202 ---NDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDR--SLVQG 256 N L A H+ P+ VK+APDL EEE+ +A++ + +DG+I +NTT+ R SL+ Sbjct: 286 SSGNVLGAKTHR-PPVLVKVAPDLEEEEIKAIAEAAKKSKVDGIIVSNTTIQRPASLITE 344 Query: 257 MKN-CDQTGGLSGRPLQLKSTEIIRRLSLELNGR-LPIIGVGGIDSVIAAREKIAAGASL 314 KN Q GGLSG+PL+ S + ++ ++ G L ++G GGI S A E AGA++ Sbjct: 345 DKNLVAQAGGLSGKPLKPLSLKALKTMAHYTKGSGLVLVGCGGISSGADAIEFAKAGATM 404 Query: 315 VQIYSGFIFKGPPLIKEIVTHI 336 V++Y+ + ++GP LI + I Sbjct: 405 VELYTCYAYRGPGLIARVKDEI 426 >UniRef50_Q5KK62 Dihydroorotate dehydrogenase, mitochondrial, putative n=3 Tax=Agaricomycotina RepID=Q5KK62_CRYNE Length = 591 Score = 207 bits (527), Expect = 5e-52, Method: Compositional matrix adjust. Identities = 134/324 (41%), Positives = 181/324 (55%), Gaps = 41/324 (12%) Query: 50 MGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGL 109 G+ KNP+G+AAG DKD E ID L +GFG +E+G+VTP PQPGN KPR FRL + + Sbjct: 109 FGMHLKNPVGIAAGFDKDAEAIDGLFDLGFGYVEVGSVTPEPQPGNPKPRFFRLEEDDAC 168 Query: 110 INRMGFNNLG---------------------------VDNLVENV---KKAHYDGVLGIN 139 INR GFN+LG NLV + +L +N Sbjct: 169 INRYGFNSLGHGHALARLRLRLAKFAQDHPSLFPSPLPANLVPPAGLPRSLRAGQLLAVN 228 Query: 140 IGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKN 199 +GKNK + + DDY+ + + +A + IN+SSPNTPGLR LQ + L+ LL + Sbjct: 229 LGKNKASDPDS-NDDYVRGVRTLGPFADVVVINVSSPNTPGLRALQGKQQLERLLNDVVE 287 Query: 200 KQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDR---SLVQG 256 ++N + A IAVK+A DLSE+EL VA ++ ++GVI +NTT+ R +LV G Sbjct: 288 ERNKI-AQGTGLPKIAVKVASDLSEDELADVASAVRSSGVEGVIVSNTTIRRKELNLVSG 346 Query: 257 MKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQ 316 N DQ GGLSG+PL + ++ L L +PIIG GGI S A AGAS+VQ Sbjct: 347 --NQDQIGGLSGKPLFPYALNALKTLRPLLPPSIPIIGCGGISSGSDALTMANAGASIVQ 404 Query: 317 IYSGFIFKG---PPLIK-EIVTHI 336 +Y+ F F+G P LIK EI H+ Sbjct: 405 VYTSFGFRGVGTPRLIKDEITEHL 428 >UniRef50_A9F3A8 PyrD protein n=1 Tax=Sorangium cellulosum 'So ce 56' RepID=A9F3A8_SORC5 Length = 407 Score = 207 bits (526), Expect = 6e-52, Method: Compositional matrix adjust. Identities = 138/346 (39%), Positives = 186/346 (53%), Gaps = 19/346 (5%) Query: 3 YPFVRKALFQLDPERAHEFTFQQLRRIT-GTPFEALVRQKVPAK----PVNCMGLTFKNP 57 Y VR LF L P AHE L I P ALV ++ + V MGL F +P Sbjct: 31 YRLVRPLLFALPPSLAHELGMLALAPIEHAAPLRALVHARLAPRDGRIAVRTMGLDFPSP 90 Query: 58 LGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNN 117 LG+A G DKD AL A+GFG +E+GTVT +PQ N P LFRL LINR+GF N Sbjct: 91 LGVAGGFDKDARRARALAALGFGFVELGTVTAQPQAANPPPNLFRLPADRALINRLGFPN 150 Query: 118 LGVDNLVENV----KKAHYDGVLGINIGKNKDT---PVEQGKDDYLICMEKIYAYAGYIA 170 G + E + A +GI+IGK++ P+E DDYL + A ++ Sbjct: 151 QGAARVTERLLGRGGTAAVGVPVGISIGKSRVAPLDPIEPAIDDYLASFREARRAADFVV 210 Query: 171 INISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQV 230 IN+SSPNT LR +Q LL+AI + A +P+ +K+APDL +EEL + Sbjct: 211 INVSSPNTKDLRAMQGPAIARALLSAIARENRAAGA----PLPLLIKVAPDLGDEELEAL 266 Query: 231 ADSLVRHNIDGVIATNTTLDR-SLVQGMKNCDQ--TGGLSGRPLQLKSTEIIRRLSLELN 287 + + GVIATNTT+ R L + + GGLSG PL+ +S ++RR+ L Sbjct: 267 LAVVEEVGLAGVIATNTTVRRDGLATSPADVEAMGAGGLSGPPLRQRSLAMVRRIRARLG 326 Query: 288 GRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIV 333 + +IG GGI+S A +++ AGA LVQIY+GFI+ GP L EI Sbjct: 327 SNVTVIGAGGIESAEHAMDQLQAGADLVQIYTGFIYGGPLLPAEIA 372 >UniRef50_B6KTR1 Dihydroorotate dehydrogenase n=4 Tax=Toxoplasma gondii RepID=B6KTR1_TOXGO Length = 592 Score = 206 bits (523), Expect = 1e-51, Method: Compositional matrix adjust. Identities = 137/375 (36%), Positives = 196/375 (52%), Gaps = 49/375 (13%) Query: 2 YYPFVRKALFQ------LDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFK 55 +Y V LF+ LDPE AH +T + +R P + ++ A V+ GL F Sbjct: 185 FYEPVTSVLFRYFSSGPLDPETAHGYTMELAKR-GWLPVD--YDREESALNVDINGLKFL 241 Query: 56 NPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGF 115 +P+GLAAG DK E AL MGF +E+G++TP+PQPGN KPRLFRL + +INR GF Sbjct: 242 SPIGLAAGFDKHAEAPAALLRMGFSFLEVGSITPKPQPGNPKPRLFRLYEDRSVINRFGF 301 Query: 116 NNLGVD---NLVENVKKAHY------DGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYA 166 N+ G D +E +A GVLG+++GKNK + E D ++K+ +A Sbjct: 302 NSNGADYAQTQLEAFSEARLRDPFTAQGVLGVSLGKNKTS--EDAVADLREGVKKLGRFA 359 Query: 167 GYIAINISSPNTPGLRTLQYG--------------EALDDLLTAIKNKQNDLQAMH---- 208 ++ +N+SSPNTPGLR+LQ +ALD A KQ + + H Sbjct: 360 DFLVVNLSSPNTPGLRSLQSASHLAAIIDGVQEELDALDRQAQAASQKQRNERRRHGGNP 419 Query: 209 -----------HKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGM 257 + VKIAPDLS EE +A + N+DG + +NTT+ R Sbjct: 420 EETKAFYANQTGRRPLFFVKIAPDLSMEEKESIAKVALEKNLDGFVVSNTTIQRPETLKS 479 Query: 258 KNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQI 317 +TGGLSGR L+ ST + + G+L II GG++S A +KI AGASLV++ Sbjct: 480 PAKSETGGLSGRALKHLSTACVSDMYKLTQGKLAIIATGGVESGRDALDKIEAGASLVEL 539 Query: 318 YSGFIFKGPPLIKEI 332 YS ++ GP + + + Sbjct: 540 YSSMVYIGPQVARRV 554 >UniRef50_A5K1N1 Dihydroorotate dehydrogenase, mitochondrial, putative n=1 Tax=Plasmodium vivax RepID=A5K1N1_PLAVI Length = 572 Score = 204 bits (520), Expect = 3e-51, Method: Compositional matrix adjust. Identities = 136/377 (36%), Positives = 198/377 (52%), Gaps = 60/377 (15%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 +Y F++ L +D E HE F + + P++ + GL F NP G+ Sbjct: 169 LYDVFLKMLLKYVDGETCHEL-FLLMGKYKLLPYDTGKDNIYSCSEIK--GLNFINPFGV 225 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAG DK+G CID + +GF IEIGT+TP+ Q GN++PR+FR ++ +IN GFNN+G Sbjct: 226 AAGFDKNGVCIDGILKLGFSFIEIGTITPKAQKGNERPRIFRDLETRSIINSCGFNNMGC 285 Query: 121 DNLVENVK----KAHYDGVL-----GINIGKNKDTP-VEQGKDDYLICMEKIYAYAGYIA 170 D + +N+K + D +L G+++GKNKD+P + Q D C+ KI YA YIA Sbjct: 286 DEVCKNLKRFRERQKTDKLLQRHLVGVSLGKNKDSPDILQ---DLSYCIGKIGRYADYIA 342 Query: 171 INISSPNTPGLRTLQYGEALDDLLTAIKNKQNDL-----------------------QAM 207 IN+SSPNTPGLR Q GE L ++ +K + L +A+ Sbjct: 343 INVSSPNTPGLRDHQKGERLHGIIQRVKEEVAKLDGGGAPLGGATTGGAAMGGATTGEAV 402 Query: 208 HHKYVP-------------------IAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTT 248 K P I VK+APDL E E +A+ L+ +DG+I NTT Sbjct: 403 VGKAPPDEAATGGEPWANTTKRRPLIFVKLAPDLEEGERKSIANVLLNAEVDGMIICNTT 462 Query: 249 LDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKI 308 + ++ + D+ GG+SG L+ ST +I ++ NG++PII GGI + A EKI Sbjct: 463 TQKFNIKSFE--DKKGGVSGEKLKGVSTHMISQMYNYTNGKIPIIASGGIFTGEDALEKI 520 Query: 309 AAGASLVQIYSGFIFKG 325 AGAS+ Q+YS +F G Sbjct: 521 EAGASVCQLYSCLVFNG 537 >UniRef50_Q83GM4 Dihydroorotate oxidase n=2 Tax=Tropheryma whipplei RepID=Q83GM4_TROWT Length = 335 Score = 203 bits (517), Expect = 6e-51, Method: Compositional matrix adjust. Identities = 124/336 (36%), Positives = 185/336 (55%), Gaps = 29/336 (8%) Query: 3 YPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAK-----PVNCMGLTFKNP 57 Y + L +DPE AH RI ++ + VP + MGL F P Sbjct: 2 YSYFLNFLKCVDPELAH--------RIAAVALKSGLGMFVPQRFHIHLGTTSMGLYFDTP 53 Query: 58 LGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNN 117 LG+AAG DK + + L ++GFG +E+GTVT PQPGN KPR+ R++ + LIN MGFNN Sbjct: 54 LGIAAGFDKFADLVIPLYSLGFGHVEVGTVTLHPQPGNKKPRIHRVMSQKALINSMGFNN 113 Query: 118 LGVDNLVENVKKAHYDG----VLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINI 173 G + EN+ K G ++G+NIGK+K P+E+ DY+ E + + Y+ IN+ Sbjct: 114 PGAQKMRENILKVRKSGRRLPIIGVNIGKSKVCPLEESAKDYVKSFELLADVSDYLVINV 173 Query: 174 SSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADS 233 SSPNT GLRTLQ L+ +L ++K + + P+ +KI+PDLS ++ +A Sbjct: 174 SSPNTEGLRTLQSVGNLNKILRSVKPIADRFKR------PVLIKISPDLSNSDVTNIALL 227 Query: 234 LVRHNIDGVIATNTTLDRSLVQGMKN--CDQTGGLSGRPLQLKSTEIIRRLSLEL-NGRL 290 + + GV+A+NTT R+ G+ N GGLSG L+ +S E+++ L +L + Sbjct: 228 VKEFGLAGVVASNTTTKRT---GLPNEFSSLHGGLSGPMLKERSLEMLKILRRDLPKNKF 284 Query: 291 PIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGP 326 II VGG+ E++ GA LVQ Y+ F++ GP Sbjct: 285 CIISVGGVWDYTDVLERLEYGADLVQGYTAFVYNGP 320 >UniRef50_D0IRU1 Dihydroorotate dehydrogenase n=1 Tax=Helicobacter pylori 51 RepID=D0IRU1_HELP1 Length = 330 Score = 202 bits (515), Expect = 1e-50, Method: Compositional matrix adjust. Identities = 124/314 (39%), Positives = 172/314 (54%), Gaps = 18/314 (5%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPF-----EALVRQKVPAKPVNCMGLTFK 55 M Y ++K LF LD E AHE + L+ ++ +PF ++ K P +GL F Sbjct: 1 MLYSLLKKYLFSLDAEYAHEKVCKILKVLSSSPFLCGLIDSQWGYKNPKLENEILGLHFP 60 Query: 56 NPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGF 115 NPLGLAAG DK+ + AL A GFG +E GT+T Q GN++PRLFR ++ E L N MGF Sbjct: 61 NPLGLAAGFDKNISMLRALIAFGFGYLEAGTLTNAAQSGNERPRLFRHIEEESLQNAMGF 120 Query: 116 NNLGVDNLVENVKK-AHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINIS 174 NN G + + A Y +GIN+GKNK +DY + K Y N+S Sbjct: 121 NNHGAVLGARSFNRFAPYKTPIGINLGKNKHIEQAHALEDYKAVLNKCLNIGDYYTFNLS 180 Query: 175 SPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSL 234 SPNTP LR LQ +++L K M HK P+ +KIAPDL +++++V +S Sbjct: 181 SPNTPNLRDLQNKAFVNELFCMAKE-------MTHK--PLFLKIAPDLEIDDMLEVVNSA 231 Query: 235 VRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIG 294 + G+IATNTT+D+SLV K + GGLSG+ L KS EI + L+ + ++ Sbjct: 232 IEAGAHGIIATNTTIDKSLVFAPK---EMGGLSGKCLTKKSREIFKELAKAFFNKSVLVS 288 Query: 295 VGGIDSVIAAREKI 308 VGGI A E+I Sbjct: 289 VGGISDAKDAYERI 302 >UniRef50_A6BB63 Dihydroorotate dehydrogenase n=1 Tax=Vibrio parahaemolyticus AQ3810 RepID=A6BB63_VIBPA Length = 181 Score = 201 bits (512), Expect = 2e-50, Method: Compositional matrix adjust. Identities = 91/153 (59%), Positives = 131/153 (85%) Query: 184 LQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVI 243 ++YGEALD+LL+ +K KQ++L H KYVP+A+KIAPDLS++E+ Q+ +SL+++NIDGVI Sbjct: 29 MEYGEALDELLSELKAKQSELAEKHGKYVPLALKIAPDLSDDEITQICESLLKNNIDGVI 88 Query: 244 ATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIA 303 ATNTTLDR++V+GMK+ ++ GGLSGRP+Q +STE++R+L L +LPIIGVGGIDS +A Sbjct: 89 ATNTTLDRTVVEGMKHANEAGGLSGRPVQSRSTEVVRKLHEALGDKLPIIGVGGIDSYVA 148 Query: 304 AREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 A+EK+ AGA LVQ+Y+GFI+ GP L+++IV ++ Sbjct: 149 AKEKMMAGAQLVQVYTGFIYHGPGLVRDIVKNL 181 >UniRef50_Q2S001 Dihydroorotate oxidase n=2 Tax=Rhodothermaceae RepID=Q2S001_SALRD Length = 366 Score = 201 bits (511), Expect = 3e-50, Method: Compositional matrix adjust. Identities = 118/298 (39%), Positives = 172/298 (57%), Gaps = 22/298 (7%) Query: 50 MGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGL 109 G TF NP+GLAAG DK+ + A+GFG +E+G+V+ +P PGN PR FRL + L Sbjct: 52 WGDTFPNPVGLAAGADKNARAVPFWEAVGFGFVEVGSVSAQPAPGNPTPRAFRLPKDQAL 111 Query: 110 INRMGFNNLGVDNLVENVKKAHYDGV--LGINIGKNKDTPV--EQGKDDYLICMEKIYAY 165 INR+G NN G + + + ++ + D LGIN+ K D + E +D+ ++ Sbjct: 112 INRLGLNNDGAEAVADRLEHSRSDRARPLGINLAKTHDPDIMGEAALEDFRTSFRQLVGQ 171 Query: 166 AGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSE- 224 A Y+ +N+S PNTP T + ALD LL AI +Q VP+ VK++P LS+ Sbjct: 172 ADYVTLNVSCPNTPDGGTFEDPAALDALLGAITAEQK----APGLAVPVLVKLSPPLSDR 227 Query: 225 -------EELIQVADSLVRHNIDGVIATNTTLDRSLVQ-GMKNCDQ--TGGLSGRPLQLK 274 EE++ VA H+IDG IATNT DR V+ D+ GGLSG PL+ + Sbjct: 228 VLFDTRLEEILAVA---ADHDIDGFIATNTASDRKGVETSADRLDEIGAGGLSGPPLEAR 284 Query: 275 STEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 +T +++ L +G +PIIGVGG+ +A KI AGASLVQ+Y+ +++GP L++ I Sbjct: 285 ATRLVQYLYRATDGEIPIIGVGGVHDAESAYTKIRAGASLVQLYTALVYEGPGLVRRI 342 >UniRef50_C0W1V7 Possible dihydroorotate oxidase n=1 Tax=Actinomyces coleocanis DSM 15436 RepID=C0W1V7_9ACTO Length = 341 Score = 201 bits (510), Expect = 4e-50, Method: Compositional matrix adjust. Identities = 127/343 (37%), Positives = 183/343 (53%), Gaps = 33/343 (9%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLR------------RITGTPFEALVRQKVPAKPVN 48 MY + DPE AH L R T P + + P Sbjct: 1 MYRWLFDNLITHSDPETAHNLVMNALTVAGSNPVSRAAIRATFNPTDTSLEPNASFLPKR 60 Query: 49 CMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEG 108 G LGLAAG+DK+ E I A A+GFG IEIGT+TP+ QPGN +PRL+RL + Sbjct: 61 VQGR-----LGLAAGMDKNAEAIHAFSALGFGFIEIGTITPKGQPGNPQPRLWRLPETRE 115 Query: 109 LINRMGFNNLGVDNLVENVKK-----AHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIY 163 + N+MGFNN GVD + + K A V+G NIGKNK T ++ +DY IC + Sbjct: 116 IRNQMGFNNHGVDAALLKLTKLRSTEAGRKIVVGSNIGKNKITSNDEALNDYEICASTLA 175 Query: 164 AYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLS 223 + ++ IN+SSPNTPGLR LQ E+L ++ + N+ + V + +KIAPDL+ Sbjct: 176 PLSDFLVINVSSPNTPGLRDLQTVESLRPIVETTQESANN---AAQRDVSVFIKIAPDLA 232 Query: 224 EEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLS 283 +E+++ VAD + + GV+A NTT+ K+ ++GG+SG L + +I+ L Sbjct: 233 DEDILAVADLVNETGLTGVVAANTTI--------KHSYESGGISGPRLLNRGLDIVANLR 284 Query: 284 LELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGP 326 EL+ IIGVGGI + A + AGA L++ + FI++GP Sbjct: 285 KELDYDKTIIGVGGISTPDDAISYLDAGADLLEALTAFIYEGP 327 >UniRef50_A7AUQ8 Dihydroorotate dehydrogenase n=2 Tax=Piroplasmida RepID=A7AUQ8_BABBO Length = 415 Score = 200 bits (508), Expect = 7e-50, Method: Compositional matrix adjust. Identities = 129/337 (38%), Positives = 188/337 (55%), Gaps = 29/337 (8%) Query: 13 LDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDGECID 72 LDPE AH+ + L+ + P + V P + F NP+G+AAG DK E Sbjct: 33 LDPEVAHKLSITALK-LGIAPVDYSVDP--PVIQSRLKDVVFFNPIGMAAGYDKQVEVPL 89 Query: 73 ALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKKAH- 131 + MGFG +E+GTV P PQ GN KP +FRL D++ LIN GFN++G++ +K+ Sbjct: 90 QILRMGFGFVEVGTVLPLPQEGNPKPVMFRLHDSKALINCCGFNSVGLEVAKARLKRVRK 149 Query: 132 --------YDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRT 183 D ++G+++GKN+ + D + ++ + YA YIAIN+SSPNTP LR Sbjct: 150 KQASDPLTKDFMIGVSVGKNRTGDILA---DTVNAVKGVAPYADYIAINVSSPNTPNLRD 206 Query: 184 LQYGE-----------ALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVAD 232 Q E AL+ + T IK+K + K + +KI+PD+S +EL +AD Sbjct: 207 NQKREPLIAVISAARSALEIVNTEIKSKGAEFNNTTKKVPLLLIKISPDVSRQELEDIAD 266 Query: 233 SLVRHNIDGVIATNTTLDRSLV--QGMKNC-DQTGGLSGRPLQLKSTEIIRRLSLELNGR 289 + H++DG+IATNTT+ R V +K + GGLSGRPL+ S +I+ L G+ Sbjct: 267 ISLTHHVDGIIATNTTITRDNVVPSDLKTAGNPKGGLSGRPLKTMSKKIVYDLYELTEGK 326 Query: 290 LPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGP 326 +PII GGI + A E I AGASL QIY+ +++GP Sbjct: 327 IPIIACGGISTAQDALEMIEAGASLCQIYTALVYEGP 363 >UniRef50_D1CE91 Dihydroorotate dehydrogenase n=1 Tax=Thermobaculum terrenum ATCC BAA-798 RepID=D1CE91_THET1 Length = 376 Score = 197 bits (502), Expect = 4e-49, Method: Compositional matrix adjust. Identities = 133/339 (39%), Positives = 183/339 (53%), Gaps = 19/339 (5%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPF-----EALV---RQKV-PAKPVNCMG 51 +Y V L +LD E HE L + P E L R+ V P V+ G Sbjct: 5 IYKHLVLPLLDRLDSETWHERVRHGLHTVEQVPLGPEFLEILAWKGRRVVDPRLKVSLAG 64 Query: 52 LTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLIN 111 + +NPL + AG DK G I AL A+GF S+E+GTVTPRPQPGN +PR F L +IN Sbjct: 65 VQLENPLIVGAGWDKSGISIRALYALGFASVEVGTVTPRPQPGNPRPRQFVLSSGV-VIN 123 Query: 112 RMGFNNLGVDNLVENVKKAHYDGV-LGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIA 170 R+GFNN G D + N++ D + +GI+IGKNKD P ++ Y K+Y Y Y Sbjct: 124 RLGFNNPGADAVAANLESYKSDNIPVGISIGKNKDDPEDRAPLAYAEVARKLYPYGSYFV 183 Query: 171 INISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQV 230 IN+SSPNTPGLR+LQ EA L +I D+ + P+ +KIAP+LS +E+ ++ Sbjct: 184 INVSSPNTPGLRSLQRKEA----LLSIAQSVLDVMDSYGARKPLFIKIAPELSYQEVDEI 239 Query: 231 ADSLVRHNIDGVIATNTTL--DRSLVQGMKNCDQTGGLSG--RPLQLKSTEIIRRLSLEL 286 D +++ + GV+ATNT D G Q GGLSG + ST + + + Sbjct: 240 LDVVLQLGLAGVVATNTVALGDVKARYGEGWRLQPGGLSGDDEVFRHMSTSKVAYIYSQT 299 Query: 287 NGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKG 325 G + IIGVGG+ A EKI AGA+ VQ+ + +G Sbjct: 300 KGSIDIIGVGGVKDAHTALEKILAGATAVQVVTAIRSEG 338 >UniRef50_C6IFT5 Dihydroorotate dehydrogenase 2 n=7 Tax=Bacteroides RepID=C6IFT5_9BACE Length = 332 Score = 197 bits (502), Expect = 4e-49, Method: Compositional matrix adjust. Identities = 123/339 (36%), Positives = 180/339 (53%), Gaps = 20/339 (5%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGT-PFEALVRQKVPA-KPVNCMGLTFKNPL 58 MY VR LF +DPE+ H L+ P A VR +P + L FKN + Sbjct: 1 MYNLIVRPLLFLIDPEKVHRMLLNWLKIYRYLLPVRACVRGHYQVDEPFSYGSLRFKNRI 60 Query: 59 GLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNL 118 GL+AG DK+ E D L GFG +E+GTVTP QPGN PR+FRLV+ E LI+R GFNN Sbjct: 61 GLSAGFDKNAETFDELADFGFGFLEVGTVTPDYQPGNPSPRIFRLVEDESLISRTGFNNC 120 Query: 119 GVDNLVENVKKAH-YDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPN 177 GVD +E+++K + LG+NI KN + EQ D+ + ++Y Y +N S + Sbjct: 121 GVDVALEHIRKYRKHSYRLGVNINKNPLSAGEQIIKDFELVFTRLYESVDYFTLNWGSID 180 Query: 178 TPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRH 237 + + L++L T + +K I +K+ D+ E+ L V ++ Sbjct: 181 KE-----SFAKVLENLTT--------FRQAVNKRCSIFIKLPADIDEKALDLVISLAYKY 227 Query: 238 NIDGVIATNTTLDRSLVQGMKNCD----QTGGLSGRPLQLKSTEIIRRLSLELNGRLPII 293 +I+G IAT T+DRS + K GG+SGR + KS +++R LS + II Sbjct: 228 SIEGFIATGPTMDRSELHHTKTKQLEKIGNGGVSGRGIGKKSQKVVRYLSGHTDHHFLII 287 Query: 294 GVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 G GGI + A + I+ GA ++QIYS FI+ GP ++ +I Sbjct: 288 GAGGIMTAEDAADMISQGADMIQIYSAFIYSGPSVVHKI 326 >UniRef50_A8Q682 Putative uncharacterized protein n=1 Tax=Malassezia globosa CBS 7966 RepID=A8Q682_MALGO Length = 665 Score = 190 bits (482), Expect = 6e-47, Method: Compositional matrix adjust. Identities = 126/342 (36%), Positives = 181/342 (52%), Gaps = 63/342 (18%) Query: 50 MGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRL-VDA-- 106 G T NP+GLAAG DK GE ID L +GFG +EIG++TP PQPGN PR+FRL +DA Sbjct: 120 FGKTLTNPIGLAAGFDKQGEAIDGLFDLGFGLVEIGSITPEPQPGNPTPRMFRLPLDAAV 179 Query: 107 ---------------------------------EGLINRMG--------------FNNLG 119 EGL++ +G F N Sbjct: 180 INRMGFNSEGHEAVRERLHARLHKWVQRVLSAGEGLVSSVGAPAPEPTALAEAQVFANYP 239 Query: 120 VDN--LVENV---KKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINIS 174 V N L+++ + D +L IN+GKNK + E DY+ ++ + AYA + IN+S Sbjct: 240 VINTSLLDDAHVPRSLKQDRLLSINLGKNKSS-REDSVVDYVKGVQALGAYADMLVINVS 298 Query: 175 SPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSL 234 SPNTPGLR LQ L+ +L + ++D+ +P+ VK+APDLS+ EL VAD+ Sbjct: 299 SPNTPGLRRLQRRSVLEGVLRDVVTARDDVAKQRIDSLPLVVKVAPDLSDAELEDVADAA 358 Query: 235 VRHNIDGVIATNTTLDRSL-VQGMKNCDQTGGLSG---RPLQLKSTEIIRRLSLELNGRL 290 IDG+I +NTT+ R + ++ + GGLSG +PL L + ++I + S G++ Sbjct: 359 RASKIDGIIVSNTTVSRPAGLLSTQHVHEAGGLSGPPVKPLALHALQVIYKRS---EGKI 415 Query: 291 PIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 P+IG GGI + A E AGAS VQ+Y+ ++GP L + I Sbjct: 416 PLIGCGGIMTAEDALEFARAGASAVQLYTALAYRGPGLPRRI 457 >UniRef50_B5CXJ8 Putative uncharacterized protein n=3 Tax=Bacteroides RepID=B5CXJ8_9BACE Length = 349 Score = 189 bits (481), Expect = 8e-47, Method: Compositional matrix adjust. Identities = 126/344 (36%), Positives = 181/344 (52%), Gaps = 23/344 (6%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITG-TPFEALVR--QKVPAKPVNCMGLTFKNP 57 MY +R LF++D E+ H L P + L+R + A P LTF N Sbjct: 21 MYKSILRPWLFRMDAEKIHGQIVALLHVYRHFPPVKCLLRVFYRPKATPFQWRNLTFANR 80 Query: 58 LGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNN 117 +GL+AG DK+ C D L +GFG +E+GTVTP GN PR+FRL + L++R GFNN Sbjct: 81 VGLSAGFDKEANCFDELSDLGFGFLEVGTVTPEKVAGNPFPRIFRLPEDHALVSRTGFNN 140 Query: 118 LGVDNLVENV-KKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSP 176 G + +++N+ +K +LG+NI N T E+ D E AYA Y IN S Sbjct: 141 PGKEVVLKNLQRKREGKYILGVNINTNTPTDAERAVTDITDLYETFSAYADYYTINWGS- 199 Query: 177 NTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVR 236 TP E L D+LTA+++ + Q H P+ +K+ D+ E+L V + Sbjct: 200 MTP--------EILADVLTALESYK---QRFHR---PVFLKLPADVPAEKLDTVIEFAKV 245 Query: 237 HNIDGVIATNTTLDRSLVQGMKNCDQ----TGGLSGRPLQLKSTEIIRRLSLELNGRLPI 292 H+IDG IAT T DRSL+ + GG+SG P+ KS E+++ LS + + Sbjct: 246 HHIDGFIATGPTQDRSLLIHSAQTEVERVGAGGISGLPVIHKSLEVMKHLSAHAPKDMLL 305 Query: 293 IGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 IG GG+ + A+ AGA LVQ+YS FI++GP ++K I I Sbjct: 306 IGAGGVMTPFEAKAMRNAGAHLVQVYSAFIYEGPGVVKRIAEKI 349 >UniRef50_A2VBP6 Dihydroorotate dehydrogenase, mitochondrial n=1 Tax=Dekkera bruxellensis RepID=A2VBP6_DEKBR Length = 442 Score = 181 bits (458), Expect = 5e-44, Method: Compositional matrix adjust. Identities = 114/319 (35%), Positives = 179/319 (56%), Gaps = 30/319 (9%) Query: 43 PAKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFR 102 P V+ G T NP+G+AAG DK E +DAL +GFG +E+GT+TP PQ GN +PR FR Sbjct: 107 PILRVDLFGRTLANPIGMAAGFDKQAEAMDALYDLGFGIVEVGTITPEPQFGNPRPRFFR 166 Query: 103 LVDAEGLINRMGFNNLGVDNLVENVK----------------KAHYDG-VLGINIGKNKD 145 L E +INR G N+ G ++ ++ + +G L +NIGKN++ Sbjct: 167 LNADETVINRYGLNSDGRLTILSRLRVRLEKYLKKSNACKTNNSFREGKSLFVNIGKNRN 226 Query: 146 TPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQ 205 DDYL+ ++ YA + +N+S P+ PG+R LQ + L +LLT ++ +++ + Sbjct: 227 GDT---IDDYLVGVDTFAPYADALVLNVSCPSAPGVRDLQEKDVLLELLTKVREERDKVG 283 Query: 206 AM---HHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDR--SLVQGMKNC 260 A + PI VK+APDLSE+E+ +AD + IDG++ +NTT R SL+ Sbjct: 284 ANVIDPARKPPIIVKVAPDLSEKEIADIADVAKKSKIDGILMSNTTTARPASLITKGPVV 343 Query: 261 DQTGGLSGRPLQ---LKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQI 317 + GGLSGR ++ LK+ +R+ + + + L +IG GGI + A AGAS +++ Sbjct: 344 QEKGGLSGRAMRDISLKAFRTLRKYTKDSD--LVLIGCGGIFTGKDAIAFAKAGASAIEL 401 Query: 318 YSGFIFKGPPLIKEIVTHI 336 Y+ F ++GP + +I I Sbjct: 402 YTSFAYRGPGIPDKIKDEI 420 >UniRef50_Q6MPX3 PyrD protein n=1 Tax=Bdellovibrio bacteriovorus RepID=Q6MPX3_BDEBA Length = 327 Score = 173 bits (439), Expect = 6e-42, Method: Compositional matrix adjust. Identities = 113/331 (34%), Positives = 173/331 (52%), Gaps = 27/331 (8%) Query: 13 LDPERAHEFTFQQLRRITGTPFEALVR-QKVP-AKPVNCMGLTFKNPLGLAAGLDKDGEC 70 L P+ AH+ + G P +L+ +K P K GL F NP+G+A G+DK+ E Sbjct: 7 LPPQWAHDLS------SLGLPLYSLIHGRKTPHWKSFTWRGLEFANPMGIAGGVDKNAEH 60 Query: 71 IDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKK- 129 + A+G G +E+GT+TPR Q N + R ++ + + N+MGF + G D + N+ Sbjct: 61 LKEWWALGCGFVEVGTITPRAQTPNPGKIMDRDLELQAMWNKMGFPSDGGDEVFHNLASY 120 Query: 130 -AHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGE 188 +Y + +NIGKN+ TP DYL +++ +A +NISSPNT GLR LQ E Sbjct: 121 APNYRTPIFVNIGKNRHTPNNDAVADYLTLVDQFRPFADAFVVNISSPNTAGLRDLQKKE 180 Query: 189 ALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTT 248 L L+ I ++ H + P+ VK++PD+ EE L + + +DG + TNTT Sbjct: 181 NLRALIGPIVDR-----VSHFEPTPVLVKLSPDMGEEGLAEAVSNCQELGVDGFVLTNTT 235 Query: 249 LDRSLVQGMKNCD--QTGGLSGRPLQLKSTEIIRRLSLELNGR----LPIIGVGGIDSVI 302 L R C GGLSG PL+ S + +++++ G+ L ++ VGGI S Sbjct: 236 LSRP-----AGCHFPAEGGLSGAPLKQLSQRAL-QIAVQTLGKKREGLLLVSVGGIMSPE 289 Query: 303 AAREKIAAGASLVQIYSGFIFKGPPLIKEIV 333 E++ GA LVQIYS +F GP ++ Sbjct: 290 DVFERLQMGADLVQIYSALVFHGPGFFHDVA 320 >UniRef50_Q00YC9 Dihydroorotate dehydrogenase (ISS) (Fragment) n=1 Tax=Ostreococcus tauri RepID=Q00YC9_OSTTA Length = 369 Score = 168 bits (425), Expect = 3e-40, Method: Compositional matrix adjust. Identities = 90/200 (45%), Positives = 127/200 (63%), Gaps = 3/200 (1%) Query: 134 GVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDL 193 GVLG+N+GKNK TP DDY++ ++ I Y YI +N+SSPNTPGLR LQ + L L Sbjct: 16 GVLGVNLGKNKTTPEANAADDYVLGVDNIGEYGDYIVVNVSSPNTPGLRNLQGRKHLSGL 75 Query: 194 LTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDR-S 252 L + + ++ A K P+ VKIAPDL++ E+ VA + +DGVI +NTT+ R Sbjct: 76 LRKVLSARDRNPATAKK--PVLVKIAPDLTDAEIKDVASVVKSEKVDGVIVSNTTVARPE 133 Query: 253 LVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGA 312 ++ K+ D+ GGLSG+PL ST ++ L G++P++G GG+ S A KI AGA Sbjct: 134 EIKAHKHGDEAGGLSGKPLMESSTRVLHELYRLTGGKIPLVGCGGVASGEDAYAKIRAGA 193 Query: 313 SLVQIYSGFIFKGPPLIKEI 332 +LVQ+Y+ F F GPPLI +I Sbjct: 194 TLVQLYTAFAFGGPPLILKI 213 >UniRef50_B2B417 Predicted CDS Pa_6_7920 n=3 Tax=Sordariomycetes RepID=B2B417_PODAN Length = 482 Score = 167 bits (422), Expect = 7e-40, Method: Compositional matrix adjust. Identities = 129/391 (32%), Positives = 186/391 (47%), Gaps = 66/391 (16%) Query: 4 PFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVR----QKVPAKP--VNCMGLTFKNP 57 P V + LF D E AH L+ + R AKP VN G+ NP Sbjct: 81 PRVIRVLFP-DAEDAHHAGTAALKALYSVGLHPRERVQDGDATGAKPLAVNVFGVELSNP 139 Query: 58 LGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNN 117 +G++AGLDKD E D L A+G G +E+G +TP PQ GN KPR+FR+V +GLINR G N+ Sbjct: 140 IGISAGLDKDAEIPDPLFALGAGVVEVGGITPLPQEGNPKPRVFRVVSTDGLINRYGLNS 199 Query: 118 LGVDNLVENVK--------------KAHYDGVLGINIG-------------KNKDT---P 147 G D + +++ K DG G+ +G KNK T Sbjct: 200 KGADAVAAHLRERLRTFARSIGFTEKEMLDGEAGVPVGSLKDGRLLCVQIAKNKKTDEKD 259 Query: 148 VEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAM 207 VE K DY+ C+ ++ YA + +N+SSPNTPGLR LQ L LL+A+ + Q Sbjct: 260 VEAVKKDYVTCVNRLAPYADVLVVNVSSPNTPGLRDLQATGPLTALLSAV---VEEAQKT 316 Query: 208 HHKYVP-IAVKIAPDLSEEELIQ-VADSLVRHNIDGVIATNTTLDRS---------LVQG 256 K P + VK++PD ++ ++ V ++ +DGVI NTT R+ Q Sbjct: 317 KRKVKPRVMVKVSPDEDDDSQMEGVVQAVWMSGVDGVIVGNTTKKRTGLVPKGVRLTSQE 376 Query: 257 MKNCDQTGGLSGRPLQLKSTEIIRR-------LSLELNG--------RLPIIGVGGIDSV 301 KN + GG SG L ++ ++ R SL+ G + I GGI + Sbjct: 377 QKNIMEDGGYSGPALFNQTLNLVGRYRKMLDSYSLKTEGLGDAFNKNQKVIFATGGITNG 436 Query: 302 IAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 A + + AGAS+ +Y+G ++ G I I Sbjct: 437 DEALKVLNAGASVAMVYTGMVYGGSGTITRI 467 >UniRef50_D1ZM19 Whole genome shotgun sequence assembly, scaffold_58 n=1 Tax=Sordaria macrospora RepID=D1ZM19_SORMA Length = 753 Score = 164 bits (416), Expect = 3e-39, Method: Compositional matrix adjust. Identities = 122/383 (31%), Positives = 183/383 (47%), Gaps = 65/383 (16%) Query: 14 DPERAHEFTFQQLRRITGTPFEALVRQKVPAKP-----VNCMGLTFKNPLGLAAGLDKDG 68 D E AH L+ + +R++VP P VN G NP+G++AGLDKD Sbjct: 367 DAEEAHHVGTAALKGLYEVGLH--IRERVPEYPNGPLSVNVFGKQLLNPIGISAGLDKDA 424 Query: 69 ECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVK 128 E D L A+G G +E+G TP PQ GN KPR+FR+ +GLINR G N+ G D + ++ Sbjct: 425 EIPDPLFALGAGVVEVGGCTPFPQEGNPKPRVFRIPTVDGLINRYGLNSRGADAMATRLR 484 Query: 129 KA-----------------------------HYDGVLGINIGKNKDT---PVEQGKDDYL 156 + H +L + I KNK T V DY+ Sbjct: 485 ERLRKFARSVGLSENQVLNEEGTDDIPPGSLHPGRLLCVQIAKNKKTDEKDVNSVIRDYV 544 Query: 157 ICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVP-IA 215 C++K+ YA + +N+SSPNTPGLR LQ E L LL+A+ + QA K P + Sbjct: 545 YCVDKLAPYADVLVVNVSSPNTPGLRDLQATEPLTKLLSAVVDAA---QATKRKNKPRVM 601 Query: 216 VKIAPDLSEEELIQ-VADSLVRHNIDGVIATNTTLDRS--LVQGMK-------NCDQTGG 265 VK++PD + ++ V +++ +DGVI NTT R+ + QG+K + GG Sbjct: 602 VKVSPDEDDNTQMEGVVEAVWNSGVDGVIVGNTTKRRTGIIPQGVKLIGDEPEVLHEEGG 661 Query: 266 LSGRPLQLKSTEIIRRLSLELNG------------RLPIIGVGGIDSVIAAREKIAAGAS 313 SG L ++ ++ R L+G + + GGI + A + + AGAS Sbjct: 662 FSGPALFDRTVSLVGRYRKMLDGYALKNEADKSAAQKVLFATGGITNGEQALKVLNAGAS 721 Query: 314 LVQIYSGFIFKGPPLIKEIVTHI 336 + +Y+G ++ G I I T + Sbjct: 722 VAMVYTGMVYGGSGTITRIKTEM 744 >UniRef50_C5K5A0 Dihydroorotate dehydrogenase, putative n=2 Tax=Perkinsus marinus ATCC 50983 RepID=C5K5A0_9ALVE Length = 471 Score = 159 bits (401), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 110/326 (33%), Positives = 171/326 (52%), Gaps = 33/326 (10%) Query: 33 PFEALVRQKV-PAKPVNCMGLTFKNPLGLAAGLDKDGE--CIDALGAMGFGSIEIGTVTP 89 P A+V V P K V G+ F P+GLAAG DK+GE + +G G EIG+V+ Sbjct: 124 PACAVVSDDVDPLKQV-LFGVEFPRPVGLAAGFDKNGELLHLLTSSTLGNGFAEIGSVSK 182 Query: 90 RPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKK-------AHYDGVLGINIGK 142 P PGN +PR+FRL +INRMG NN G L E ++ + +G++I K Sbjct: 183 EPWPGNPRPRMFRLARDGAVINRMGLNNRGAAALREKLRSMSTLLNGTRHTPPIGVSITK 242 Query: 143 NKDTPVEQGK--DDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNK 200 +E D + +++ YA YI +NIS PNT +T + EAL+ LL A+ Sbjct: 243 TPSPTIENDAAIADIVASFDEVAPYAAYIDVNISCPNTAEGKTFEDLEALEKLLGALLTW 302 Query: 201 QNDLQAMHHKYVPIAVKIAP------DLSEEELIQVADSLVRHNIDGVIATNT------- 247 + D ++ P+ VK++P D E + ++ V +DG + NT Sbjct: 303 RRD----NYPDKPVLVKLSPPPAEADDTYYEGVSRMVRKAVELGVDGFVMINTIADRGDD 358 Query: 248 -TLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAARE 306 LDRS+ G N + GG+SG+P++ ++ ++R + G++PIIG GG+ + A Sbjct: 359 LNLDRSV--GDSNHGEKGGISGKPVRQRAINLVRHVYKVTAGKVPIIGCGGVFTAQDAYR 416 Query: 307 KIAAGASLVQIYSGFIFKGPPLIKEI 332 I GASL+Q+Y+G I++GP + ++I Sbjct: 417 LIRNGASLIQVYTGMIYEGPWVFRDI 442 >UniRef50_Q4N5X1 Dihydroorotate dehydrogenase, putative n=1 Tax=Theileria parva RepID=Q4N5X1_THEPA Length = 291 Score = 158 bits (400), Expect = 2e-37, Method: Compositional matrix adjust. Identities = 98/245 (40%), Positives = 140/245 (57%), Gaps = 19/245 (7%) Query: 13 LDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDGECID 72 LDPE +H+ + L ++ TP + + P N + NP+G+AAG DK+ + Sbjct: 28 LDPEESHKLSIV-LAKLGLTPVDYSIDP--PILYNNIKHIKIFNPIGMAAGYDKNCQVPL 84 Query: 73 ALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKKAH- 131 + +GFG IE+GTV P PQPGN KPRLFRL + + LIN +GFN+LG+D VEN+K A Sbjct: 85 EILRLGFGFIEVGTVLPNPQPGNPKPRLFRLPNNKALINSLGFNSLGIDVAVENMKVARA 144 Query: 132 --------YDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRT 183 D ++GI+IGKN + + D C+E+I Y+ Y+ IN+SSPNTP LR Sbjct: 145 RQESDPLTRDSIIGISIGKNLNGEILA---DVSHCIERIGLYSDYLCINVSSPNTPNLRD 201 Query: 184 LQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVI 243 Q E L L+ KN DL+ V PD++++EL +AD + H +DG++ Sbjct: 202 NQRKEPLLKLVKTAKNALKDLETR----VSTENLTYPDVTDQELKDIADIALEHGLDGLV 257 Query: 244 ATNTT 248 TNTT Sbjct: 258 LTNTT 262 >UniRef50_C6A9A6 Dihydroorotate dehydrogenase 2 n=20 Tax=Bifidobacteriaceae RepID=C6A9A6_BIFLB Length = 386 Score = 154 bits (389), Expect = 4e-36, Method: Compositional matrix adjust. Identities = 110/335 (32%), Positives = 161/335 (48%), Gaps = 27/335 (8%) Query: 10 LFQLDPERAHEFTFQQLR--RITGT--PFEALVRQKV----PAKPVNCMGLTFKNPLGLA 61 +F P+ AH+ Q +R +ITG P L R + P N MG+ F NP GL+ Sbjct: 37 VFNHTPDIAHD---QMIRFCQITGKMPPLMWLCRTMLNYTDPILETNVMGINFANPFGLS 93 Query: 62 AGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVD 121 AGLDK+ + L GFG +G+ T RP GN +P RL + + ++ +G N G D Sbjct: 94 AGLDKNCDMAAVLDHAGFGFETVGSTTSRPCAGNPRPWFHRLPEYDSMMVHVGLANDGSD 153 Query: 122 NLVENVKKAH---YDGVLGINIGKNKDTPV---EQGKDDYLICMEKIYAYAGYIAINISS 175 ++E + A L ++I + D V +G +DY I ME+ + +N+S Sbjct: 154 VVIERAEDAWRRTQSMQLSVSIARTNDDQVGDLNEGIEDYCISMERAAGRTAMVEVNVSC 213 Query: 176 PNTP-GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSL 234 PNT G + E LD L A+ + + P VK+ + + + D L Sbjct: 214 PNTTVGEPFTESAENLDKLFAALDRIE--------RPQPTLVKMPLNKPWPQFKEFLDVL 265 Query: 235 VRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIG 294 HN+ GV N DR+ + + D GGLSG P + STE+IRR E R I G Sbjct: 266 AAHNVQGVTIANLQKDRTGLDDIPK-DWLGGLSGGPCTVASTELIRRTYAEYGDRFAIAG 324 Query: 295 VGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLI 329 VGG+ + A EKI AG+SL+ S +++GP I Sbjct: 325 VGGVFTPEQAYEKIRAGSSLIMFISSLMYRGPQQI 359 >UniRef50_Q2H299 Putative uncharacterized protein n=3 Tax=cellular organisms RepID=Q2H299_CHAGB Length = 596 Score = 141 bits (355), Expect = 3e-32, Method: Compositional matrix adjust. Identities = 104/317 (32%), Positives = 165/317 (52%), Gaps = 34/317 (10%) Query: 47 VNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDA 106 V G T NP+G++AGLDKD E D L A+G G +E+G TP PQ GN +PR+FR+ Sbjct: 270 VTVFGTTLANPIGISAGLDKDAEIADPLFALGAGVVEVGGCTPLPQAGNPRPRVFRVPAV 329 Query: 107 EGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNK--DTPVEQG--KDDYLICME-- 160 +GL+NR G N+ G D + +++ G+ + + + + E+G D + E Sbjct: 330 DGLVNRYGLNSRGADAMAARLRERLRKFARGLGLSEREVLEAGEEEGGCADGESVAGEAA 389 Query: 161 KIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVP-IAVKIA 219 ++ YA + +N+SSPNTPGLR LQ E L LL A+ ++ + K P + VK++ Sbjct: 390 RLAPYADVLVVNVSSPNTPGLRDLQAAEPLARLLGAV---VDEAKRAKRKVKPRVMVKVS 446 Query: 220 PDLSEE-ELIQVADSLVRHNIDGVIATNTTLDRS--LVQGMKNCD-------QTGGLSG- 268 PD ++ ++ V ++ +DGVI NTT R+ + +G+K + GG SG Sbjct: 447 PDEDDDTQMDGVVQAVWMSGVDGVIVGNTTKRRTGLVKEGIKLTGREQKALVEDGGFSGP 506 Query: 269 ----RPLQL--KSTEIIRRLSLELNG---RLP----IIGVGGIDSVIAAREKIAAGASLV 315 R L L + +++ SL+ +G P I GGI + A + + AGAS+ Sbjct: 507 AMFDRTLSLVGRYRKMLDSYSLKTSGVNDVFPTPKVIFATGGITNGDQALQVLNAGASVA 566 Query: 316 QIYSGFIFKGPPLIKEI 332 +Y+G ++ G I I Sbjct: 567 MVYTGMVYGGSGTITRI 583 >UniRef50_A3ZNL9 Dihydroorotate dehydrogenase n=2 Tax=Planctomycetaceae RepID=A3ZNL9_9PLAN Length = 372 Score = 139 bits (349), Expect = 2e-31, Method: Compositional matrix adjust. Identities = 110/360 (30%), Positives = 167/360 (46%), Gaps = 46/360 (12%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEA-LVRQK--VPAKPV--NCMGLTFK 55 +Y +R LF D E AH T R P L+R A P+ N GLTF Sbjct: 3 LYRSILRPLLFHWDAETAHHATIAACRIAGAIPLAPQLMRAWYDFAASPLESNVAGLTFP 62 Query: 56 NPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGF 115 NP+GLAAG DK+G + L + GFG EIG+++ GN +PRLFRL ++ G Sbjct: 63 NPVGLAAGWDKNGHALRLLDSWGFGFAEIGSISAAASLGNRRPRLFRLPQDRAIVVNYGL 122 Query: 116 NNLGVDNLVENVKKAHYDGVLGINIGKNKDTP------VEQGKDDYLICMEKIYAYAGYI 169 N G + + + + K LG+N+ K P E+ DDY+ + ++ +A Y+ Sbjct: 123 PNDGAEVIAQRLAKHRIRRPLGVNLVKTNQGPDAAASSAERIVDDYVCSAQAVHRHASYL 182 Query: 170 AINISSPNTPGLRTL--QYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPD------ 221 +N+S PN G + Q G ++ LLTA+ + P+ +K+AP+ Sbjct: 183 TLNLSCPNAAGGKDFFAQPG-SIRQLLTALLPLE--------IACPLFLKVAPNPDPAEI 233 Query: 222 ---LSE-EELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTE 277 L E E V L + + T R + + M G ++G+P+ S Sbjct: 234 ERLLEECEPFAAVRGFLFNLPVGKAASLALTTPRQVWEKMP-----GAVAGQPVAALSNR 288 Query: 278 IIRRLSLELNGRLP-----IIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 I E+ R+P IIG GG+ S A EK+ GASL+QIY+ +++GP ++ I Sbjct: 289 CI----AEMYQRMPRDRYVIIGGGGVFSAADAYEKMGLGASLIQIYTALVYEGPGVVGRI 344 >UniRef50_UPI00016B255A dihydroorotate dehydrogenase 2 n=4 Tax=candidate division TM7 RepID=UPI00016B255A Length = 394 Score = 137 bits (344), Expect = 7e-31, Method: Compositional matrix adjust. Identities = 99/350 (28%), Positives = 172/350 (49%), Gaps = 26/350 (7%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAK------PVNCMGLTF 54 +Y ++K LF + P++AH R P L+ + + N G+ F Sbjct: 23 LYKNVIKKFLFIIPPDKAHSILVSFARIYQSLPILPLITKFILTHRNNNRLKQNICGINF 82 Query: 55 KNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMG 114 NP+GL+AG DK+ E I + +GFG + G++T P+ GN +P +RL ++ ++ G Sbjct: 83 SNPVGLSAGFDKNIELIPTMSMVGFGYMTGGSITITPRAGNPRPWFYRLPKSKSIVVHAG 142 Query: 115 FNNLGVDNLVENVKKAHYDGV-----LGINI---GKNKDTPVEQGKDDYLICMEKI--YA 164 N G + +++N+K+ + L I+I +++D+ D M + Sbjct: 143 LANDGANIILQNIKRQYKKEANRKIPLFISIAVVARSQDSTEADIIKDVCEAMSLVSGSG 202 Query: 165 YAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSE 224 A + INIS PN + Y + LD+LL+ + D+ PI +K+ + Sbjct: 203 LAKAVEINISCPNIDDNQPFTYPDKLDNLLSQLDKINADM--------PIFIKMPNLVDF 254 Query: 225 EELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQT--GGLSGRPLQLKSTEIIRRL 282 + + + +H I+GV +N DRS + ++ GGLSG+P + +S ++I+ Sbjct: 255 VRFGLILEIISKHKINGVTISNLVKDRSNINLKDKLPESVKGGLSGKPCRDRSLDLIKFT 314 Query: 283 SLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 + RL IIGVGGI + A KI AG+SLV + +G +F+GP ++ +I Sbjct: 315 YEKYGDRLLIIGVGGIFNAEDAYLKIRAGSSLVALITGLMFEGPQMVGDI 364 >UniRef50_A2QCB1 Catalytic activity: n=26 Tax=Leotiomyceta RepID=A2QCB1_ASPNC Length = 544 Score = 134 bits (338), Expect = 3e-30, Method: Compositional matrix adjust. Identities = 116/405 (28%), Positives = 174/405 (42%), Gaps = 87/405 (21%) Query: 4 PFVRKALFQLDPERAHEF---TFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 P VR L D E AH F + L + P E A G T NP+G+ Sbjct: 129 PLVR--LLFPDAEDAHHFGVDILKTLYKYGLNPRERGDPDSDGALLTEVFGYTLSNPIGI 186 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 + GLDK + D L +G +E+G TP PQ GN +PR+FRL + +INR G N+ G Sbjct: 187 SGGLDKHADIPDPLFELGPAIVEVGGTTPLPQDGNPRPRVFRLPSQKAMINRYGLNSKGA 246 Query: 121 DNL-------VENVKKAHYDG-------------------------VLGINIGKNKDTP- 147 D++ V + AH G +L + + KNK TP Sbjct: 247 DHMAAVLEQRVRDYAYAHGFGEHELAEQRVLNGEAGVPPGSLREGKLLAVQVAKNKLTPD 306 Query: 148 --VEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQ 205 +E K DY+ C++++ YA + +N+SSPNTPGLR LQ L +L A+ + Sbjct: 307 NDIEAIKRDYVYCVDRLAKYADILVVNVSSPNTPGLRDLQATAPLTAILKAVVGAAKSID 366 Query: 206 AMHHKYVPIAVKIAPDL-SEEELIQVADSLVRHNIDGVIATNTT------LDRSLVQGMK 258 +V VK++PD ++E++ + D++ +DGVI NTT L + K Sbjct: 367 RKTKPFV--MVKVSPDEDADEQVSGICDAVWGSGVDGVIVGNTTNRRPEPLPKGFTLPSK 424 Query: 259 NCD---QTGGLSGRPLQLKSTEIIRRL----------------SLE-------------- 285 D +TGG SG L ++ ++ R +LE Sbjct: 425 EQDVLKETGGYSGPQLFDRTVALVARYRSLLDASAPAAAAVPKALEAAEPDVENVPPTVS 484 Query: 286 -----LNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKG 325 L R I GG+ + AR+ + AGAS+ +Y+ + G Sbjct: 485 EAVEGLPARKVIFASGGVTNGAQARKVLDAGASVAMMYTAITYGG 529 >UniRef50_B9TAL5 Dihydroorotate dehydrogenase, putative n=1 Tax=Ricinus communis RepID=B9TAL5_RICCO Length = 309 Score = 123 bits (309), Expect = 9e-27, Method: Compositional matrix adjust. Identities = 89/321 (27%), Positives = 150/321 (46%), Gaps = 49/321 (15%) Query: 12 QLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDGECI 71 +L+P+RA L+ + A ++ +GL F P+GLAAG DK+GE Sbjct: 27 RLEPQRARSLAILALQLASVFKKNA----TTSSRSTEVLGLRFPGPVGLAAGFDKNGELY 82 Query: 72 DALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKKAH 131 L + GFG EIGTVT P+PG +G + + ++L + + H Sbjct: 83 RYLPSAGFGFAEIGTVTLLPEPGRS----------------LGIHAV-ANSLARHARGHH 125 Query: 132 YDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALD 191 LG++I N+ T + DYL C+ + +A Y+ +N+ P L ++ L Sbjct: 126 IP--LGLSISMNRATRPQAMAQDYLACLRAAWQHADYVVLNLGVRAGPDLHQPEHRNVLA 183 Query: 192 DLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDR 251 D+L A++ ++ L +P +K+ D + Q+ D ++ I+GV+ Sbjct: 184 DVLEAVRTEKEVLFRQFGYRLPTMIKL--DQARGGTQQLMDMALKAGIEGVVLC------ 235 Query: 252 SLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAG 311 G RP T ++ ++ L GR+PI+ VGGI + A +++AAG Sbjct: 236 -------------GAGSRP-----TTLLEQMVKTLAGRIPIVAVGGIRTPQDAADRLAAG 277 Query: 312 ASLVQIYSGFIFKGPPLIKEI 332 ASLVQ+++G + GP LI ++ Sbjct: 278 ASLVQVHTGLMQSGPKLISQM 298 >UniRef50_B2WMQ8 Dihydroorotate dehydrogenase, mitochondrial n=3 Tax=Leotiomyceta RepID=B2WMQ8_PYRTR Length = 455 Score = 120 bits (300), Expect = 8e-26, Method: Compositional matrix adjust. Identities = 81/242 (33%), Positives = 120/242 (49%), Gaps = 40/242 (16%) Query: 47 VNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDA 106 V G T NP+G +AG+DK E L +G G +E+G VT PQ GN KPR+FRL Sbjct: 26 VEVFGHTLNNPIGTSAGIDKGAEIPTPLFELGAGVVEVGAVTLLPQEGNPKPRVFRLPSQ 85 Query: 107 EGLINRMGFNNLGVD-------------------NLVENVKKAHYDG------------- 134 LINR GFN+ G + L E+ ++ DG Sbjct: 86 NALINRYGFNSEGAELVASRLRQRVREFAYRIGLGLDEDAERRVLDGEAGVPPGSLLKGR 145 Query: 135 VLGINIGKNKDTP---VEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALD 191 ++ + + KNK T ++ DY + + YA + +N+SSPNTPGLRTLQ E L Sbjct: 146 LMAVQVAKNKTTSENDIDAVVRDYATAVGYVGKYADILVVNVSSPNTPGLRTLQNVEPLT 205 Query: 192 DLLTAIKNKQNDLQAMHHKYVP-IAVKIAPDL-SEEELIQVADSLVRHNIDGVIATNTTL 249 LL+ + + ++ + K P + VK++PD SE ++ + +++ +DGVI NTT Sbjct: 206 RLLSGVVSA---VKKIDRKTKPAVMVKVSPDEDSESQIAGICEAVWDSGVDGVIVGNTTK 262 Query: 250 DR 251 R Sbjct: 263 KR 264 >UniRef50_UPI00016B240E dihydroorotate dehydrogenase 2 n=1 Tax=candidate division TM7 single-cell isolate TM7c RepID=UPI00016B240E Length = 338 Score = 119 bits (299), Expect = 1e-25, Method: Compositional matrix adjust. Identities = 94/297 (31%), Positives = 146/297 (49%), Gaps = 28/297 (9%) Query: 51 GLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLI 110 G+ F+NP+GL+AG DK+ + + +GFG G+VT P+ GN +P RL + ++ Sbjct: 15 GVNFRNPIGLSAGFDKNVQLSPLMEDVGFGFASGGSVTLEPRKGNLRPWFHRLPKTKSVV 74 Query: 111 NRMGFNNLGVDNL-----VENVKKAHYDGVLGINIGKNKDTPVEQGK---DDYLIC-MEK 161 G N G++ + +K V+ + + NK T + G ++Y++ ++K Sbjct: 75 VYAGMPNYGLEKIGNYVKANRIKIQSMPTVVSVAVVANKSTKDKLGPKVPEEYIVKDVKK 134 Query: 162 IYAY------AGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIA 215 Y A + INIS PN G + Y E L+ LL I + +P Sbjct: 135 AVNYIIDNKLASIVEINISCPNA-GKESFIYPETLEILLKEIDTIDRN--------IPFW 185 Query: 216 VKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKN--CDQT-GGLSGRPLQ 272 +K+ + + +V+HNI GV N DR+ V+ +K+ D+ GGLSG P + Sbjct: 186 IKMPHLYDINQFDSLLKVIVKHNIQGVTIANLVKDRTKVE-IKDPLTDEIRGGLSGEPTR 244 Query: 273 LKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLI 329 S E+IR +L I+GVGGI S A KI AGASLV + +G F+GP L+ Sbjct: 245 KHSLELIRYAYKNYGNKLTIVGVGGIFSAEDAYAKIKAGASLVGLITGLFFEGPHLV 301 >UniRef50_Q0CXV7 Putative uncharacterized protein n=1 Tax=Aspergillus terreus NIH2624 RepID=Q0CXV7_ASPTN Length = 708 Score = 115 bits (287), Expect = 3e-24, Method: Compositional matrix adjust. Identities = 67/185 (36%), Positives = 94/185 (50%), Gaps = 35/185 (18%) Query: 48 NCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAE 107 + G T NP+G++AGLDK E D L A+G +E+G TP PQ GN +PR+FRL Sbjct: 117 HIFGYTISNPIGISAGLDKHAEIPDPLFALGPAIVEVGGTTPLPQEGNPRPRVFRLPSQR 176 Query: 108 GLINRMGFNNLGVDNLV-------------------ENVKKAHYDGVLG----------- 137 +INR G N+ G D++ E K A +G G Sbjct: 177 AMINRYGLNSKGADHMAALLDARVRAWAYAHGFGDHEAAKTAVLNGAAGVPPGSLQAGKL 236 Query: 138 --INIGKNKDTP---VEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDD 192 + + KNK TP +E K DY+ C++++ YA + +N+SSPNTPGLR LQ L Sbjct: 237 LAVQVAKNKATPDGDLEAIKRDYVYCVDRVAPYADIVVVNVSSPNTPGLRDLQATAPLTA 296 Query: 193 LLTAI 197 +L A+ Sbjct: 297 ILRAV 301 >UniRef50_C9RJ75 Dihydroorotate oxidase n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RJ75_FIBSS Length = 391 Score = 97.8 bits (242), Expect = 5e-19, Method: Compositional matrix adjust. Identities = 88/297 (29%), Positives = 135/297 (45%), Gaps = 35/297 (11%) Query: 52 LTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGN-DKPRLFRLVDAEGLI 110 L F P+ LAAG +K + I MGFG I +GT T + GN +PR+ + + + Sbjct: 73 LHFGCPIMLAAGANKTAKRICDFANMGFGGISVGTATRHVREGNTHRPRIGFIENDRAIH 132 Query: 111 NRMGFNNLGVDNLVENVKK----AH-YDGVLGINIGKNKDTPVEQGK-DDYLICMEKIYA 164 N MG NN GVD + V AH +GI++ + E K D + Y Sbjct: 133 NSMGLNNDGVDAVTRRVDTQITAAHRVQMCVGISVAETPGLTDENEKLQDIVESFSIAYR 192 Query: 165 YAGYIAINISSPNTPGLRTLQYGEALDDLLTAI---KNKQNDLQAMHHKYVPIAVKIAPD 221 A Y+ IN+S PNT R ++ + TAI +NKQ +A I K++PD Sbjct: 193 VADYVEINLSCPNTGENRLDLDMTLVNKIFTAITDYRNKQPVRKA-------IYAKLSPD 245 Query: 222 LSEEELIQVADSLVRHNIDGVIATNTTLDRSL-----------VQGMKNCDQTGGLSGRP 270 + E + D LV+ ++GV+ NT + + + ++ + GG+SGRP Sbjct: 246 MPENHTATIMDMLVKVGVNGVVMGNTYPTKKVTDLPVHVKYDDLTPLRADNDRGGMSGRP 305 Query: 271 L---QLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFK 324 L +++ + IR E ++ +I GGID + I G VQ YS F+ Sbjct: 306 LYENTVRNVKFIR----EHYPQMSVIACGGIDHGYKIYDLIKLGVDAVQCYSVVAFR 358 >UniRef50_Q2IVE7 Dihydroorotate oxidase B, catalytic subunit n=1 Tax=Rhodopseudomonas palustris HaA2 RepID=Q2IVE7_RHOP2 Length = 348 Score = 97.4 bits (241), Expect = 6e-19, Method: Compositional matrix adjust. Identities = 93/343 (27%), Positives = 144/343 (41%), Gaps = 36/343 (10%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFE-----ALVRQKVPAKPVNCMGLTFK 55 +Y + LF++ P+R+H LRR P+ A +R P G+ Sbjct: 3 LYRDLLAPGLFRMSPDRSHAMAHAALRR--AVPWRLLAAAATLRVDDPRLVTRFAGVELP 60 Query: 56 NPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGF 115 NP+GLAAG DKD E I AL +GFG + +G++ P P+ GN PRL R E + + MG Sbjct: 61 NPVGLAAGFDKDAELIAALSCLGFGFVCVGSIMPEPRVGNPFPRLVRRRGTESIADSMGV 120 Query: 116 NNLGVDNLVENVKKAHYDGVLGI-NIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINIS 174 + G E +++ V I NIG + G + ++ + + +++ Sbjct: 121 PSKGRAYATERLRRLGPRAVPVIANIGGFSADTIAAG-------VIEVAPHVDLVELSLM 173 Query: 175 SPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSE-----EELIQ 229 PN L GE D+ I + L + + I V++ D + ELI+ Sbjct: 174 CPN-----VLADGEVFDE----IGMLRGVLARLDGRAGSIVVRVPNDTTRLHDRFAELIE 224 Query: 230 VADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGR 289 V + R G+ G L GR + + + R + GR Sbjct: 225 VCIAAGVGG-----IKVGGGRRIAEPGLGT--GAGTLHGREIFDTALMNVERAAGFARGR 277 Query: 290 LPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 L I G GGI S AGAS V +YS FI++G + ++I Sbjct: 278 LAIKGNGGISSAADVLAMRRAGASCVDLYSAFIYQGWTIARDI 320 >UniRef50_B3P4V6 GG16516 n=3 Tax=cellular organisms RepID=B3P4V6_DROER Length = 139 Score = 94.0 bits (232), Expect = 8e-18, Method: Compositional matrix adjust. Identities = 44/97 (45%), Positives = 69/97 (71%) Query: 236 RHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGV 295 + ++DG+I +NTT+ R + K ++TGGLSG PL+ +STE+I ++ +G++PIIGV Sbjct: 12 KSSVDGLIVSNTTVSRENIGNNKLAEETGGLSGPPLKARSTEMIAQMYQLTDGKIPIIGV 71 Query: 296 GGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 GG+ S A EKI AGAS +QIY+ +++GP L+ +I Sbjct: 72 GGVASGYDAYEKIEAGASYIQIYTSLVYEGPALVDDI 108 >UniRef50_UPI000187EFAF hypothetical protein MPER_16226 n=1 Tax=Moniliophthora perniciosa FA553 RepID=UPI000187EFAF Length = 181 Score = 84.0 bits (206), Expect = 6e-15, Method: Compositional matrix adjust. Identities = 51/132 (38%), Positives = 76/132 (57%), Gaps = 5/132 (3%) Query: 208 HHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGM---KNCDQTG 264 H I +KIAPDL + ++ +AD + + +IDGVI +NTT R +G+ +N QTG Sbjct: 4 RHPKPRIVLKIAPDLDDTQIEDMADVIRKSSIDGVIVSNTTTQRP--KGLVSPENKGQTG 61 Query: 265 GLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFK 324 GLSG PL+ + +R L L +PIIG GGI S A + AGA++VQ+Y+ F + Sbjct: 62 GLSGPPLKSLTLNTLRILRSHLPADIPIIGCGGISSGTDALDYARAGATMVQVYTSFGYD 121 Query: 325 GPPLIKEIVTHI 336 G + + + I Sbjct: 122 GAGMCRRVKDEI 133 >UniRef50_A8MCA1 Dihydroorotate oxidase n=1 Tax=Caldivirga maquilingensis IC-167 RepID=A8MCA1_CALMQ Length = 322 Score = 83.2 bits (204), Expect = 1e-14, Method: Compositional matrix adjust. Identities = 87/342 (25%), Positives = 155/342 (45%), Gaps = 43/342 (12%) Query: 8 KALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKP--VNCMGLTFKNPLGLAAGLD 65 K L L P+ H+ T LR + + A P + + +P+G+ AG+D Sbjct: 5 KLLGYLPPDLTHDVTHLILRTYPVKVLIGTLTRLTGALPYRLRLLNRVIDSPIGIGAGID 64 Query: 66 KDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNL-- 123 KDG I + + G +G+VT +P+ GN KPR+ R + ++N MG + GVD L Sbjct: 65 KDGLLISLMSRLPIGFHIVGSVTLKPRRGNPKPRMRRYPGLDAMVNAMGLPSRGVDFLKG 124 Query: 124 VENVKKAHY--DGVLGINIGKNKDTPVEQGKDD---YLICMEKIYAYAGYIAINISSPNT 178 + N + + +LG+++ +T + D Y+ C++ +I IN+SSP Sbjct: 125 ILNNECVRWPRSKLLGVSVAGFSETEFKLLLDSLTPYMDCVD-------FIEINVSSPTY 177 Query: 179 PGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHN 238 G T + L++LL ++K Y + +K+ S + +++ ++ HN Sbjct: 178 GGSWTEPH--RLNELLNSLKG-----------YDKLVIKLPLLSSINDEVKLIKLIINHN 224 Query: 239 IDGVIATNT-TLDRSLVQGMKNCDQTGGLSGRPLQ---LKSTEIIRRLSLELNGRLPIIG 294 G+ NT ++ L G GGLSG+PL + ++ RR+ Sbjct: 225 PFGLTIANTLSIKADLPMGY------GGLSGKPLLGIVINLIKLTRRIGYGGLIIGLGGF 278 Query: 295 VGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + GID + + I A A L+ + +GF +GP ++ I+ + Sbjct: 279 MRGIDII----KGIKAEADLIGLVTGFAMEGPLVVYRIINEL 316 >UniRef50_A8QCU3 Dihydroorotate dehydrogenase, mitochondrial, putative n=1 Tax=Brugia malayi RepID=A8QCU3_BRUMA Length = 196 Score = 82.4 bits (202), Expect = 2e-14, Method: Compositional matrix adjust. Identities = 52/134 (38%), Positives = 71/134 (52%), Gaps = 5/134 (3%) Query: 48 NCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAE 107 N M + FKNPLGLAAG DKD E I L GFG IE+GTVTP PQ + L E Sbjct: 42 NVMNMHFKNPLGLAAGFDKDAEAIKGLRESGFGFIEVGTVTPLPQKDAHNSVVKLLFKDE 101 Query: 108 GLINRMGFNNLGVDNLVENVKKAH---YDGVLGINIGKNKDTPVEQGKDDYLICMEKIYA 164 G ++ F + G+ + VK+A+ D LG+NIG+N + K DY + Sbjct: 102 GYLSCGKFKSAGLSIVYLFVKRAYDRNADVPLGVNIGRN--AGFTELKVDYSLGAYYFGR 159 Query: 165 YAGYIAINISSPNT 178 ++ Y+ +N+ S N Sbjct: 160 FSNYLVVNLGSQNV 173 >UniRef50_A5AEM5 Putative uncharacterized protein n=1 Tax=Vitis vinifera RepID=A5AEM5_VITVI Length = 310 Score = 81.6 bits (200), Expect = 3e-14, Method: Compositional matrix adjust. Identities = 64/224 (28%), Positives = 89/224 (39%), Gaps = 76/224 (33%) Query: 13 LDPERAHEFTFQQLRRITGTPFEALV-RQKVPAKPV---NCMGLTFKNPLGLAAGLDKDG 68 LD E AH R LV R+K P + G F NP+GLAAG DK+ Sbjct: 95 LDAEVAHRLAVSAAAR-------GLVPREKRPDPSILGLEVWGRKFSNPVGLAAGFDKNA 147 Query: 69 ECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVD----------------------- 105 E ++ L +GFG +E+G+VTP PQ GN KPR+FRL Sbjct: 148 EAVEGLLGLGFGFVEVGSVTPVPQEGNPKPRIFRLRHEGDIVEGAPTYQVSVYDCFLPLK 207 Query: 106 ---------------AEGLINRMGFNNLGVDNLVENVKKAHYD----------------- 133 +INR GFN+ G+ + + + H Sbjct: 208 VSFSDLWAVKLLVFVVSAIINRCGFNSEGIFAVAKRLGIQHGKRKLAETSSTSSSSKDEV 267 Query: 134 --------GVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYI 169 G+LG+N+GKNK + E DY+ + + YA Y+ Sbjct: 268 KHGGKAGPGILGVNLGKNKTS--EDAAADYVQGVHSLSQYADYL 309 >UniRef50_B2V726 Dihydroorotate dehydrogenase n=2 Tax=Aquificales RepID=PYRD_SULSY Length = 311 Score = 80.5 bits (197), Expect = 8e-14, Method: Compositional matrix adjust. Identities = 78/278 (28%), Positives = 132/278 (47%), Gaps = 30/278 (10%) Query: 50 MGLTFKNPLGLAAGLDKDGECIDALGAMGF-GSIEIGTVTPRPQPGNDKPRLFRLVDAEG 108 GL FKNP+ A+G G + + + G+I + ++ +P+ GN R+ G Sbjct: 9 FGLEFKNPVWTASGTFSYGLEVAKIYDLSLLGAIVVKGLSLKPRKGNMPERIVE--TPAG 66 Query: 109 LINRMGFNNLGVDNLVENV--KKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYA 166 ++N +G N GVD + K YD + N+ + +D+YL E++ Sbjct: 67 MLNSIGLQNPGVDYFINETLPKLKKYDTKIFANV-------FGEDEDEYLAVAERLDKAD 119 Query: 167 GY--IAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDL 222 G + +N+S PN G+ E L +L+ +K P+ VK++P++ Sbjct: 120 GVHGLELNVSCPNVKKGGIAFGTDPEVLYNLVYKMKKITKK---------PLLVKLSPNV 170 Query: 223 SEEELIQVADSLVRHNIDGVIATNTTLDRSL-VQGMKN--CDQTGGLSGRPLQLKSTEII 279 S ++ AD+ V DG++ NT L ++ V+ K TGGLSG + + +I Sbjct: 171 SN--ILDTADACVSAGADGLVLINTLLGVAIDVEREKPILSTITGGLSGPAMLPIAVRMI 228 Query: 280 RRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQI 317 ++ + R+PIIGVGGI + A + I AGAS +Q+ Sbjct: 229 WQVYQKYGSRIPIIGVGGISNYKDALQHILAGASAIQV 266 >UniRef50_UPI0000D54A55 dihydroorotate dehydrogenase n=1 Tax=Psychroflexus torquis ATCC 700755 RepID=UPI0000D54A55 Length = 106 Score = 79.7 bits (195), Expect = 1e-13, Method: Composition-based stats. Identities = 39/96 (40%), Positives = 67/96 (69%), Gaps = 4/96 (4%) Query: 239 IDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGI 298 I G+I +NT++D+ +++G C GG+SG+PL +S ++++ + E + + ++GVGG+ Sbjct: 14 IKGLIVSNTSIDKDILEG---CSHEGGISGKPLFKRSNQLLKMIH-EFDKDIFLVGVGGV 69 Query: 299 DSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVT 334 S KI GASLVQIY+GFIF+GP ++K+I++ Sbjct: 70 FSKEDYENKINLGASLVQIYTGFIFEGPAIVKKILS 105 >UniRef50_C0ZGG5 Hypothetical membrane protein n=1 Tax=Brevibacillus brevis NBRC 100599 RepID=C0ZGG5_BREBN Length = 631 Score = 77.4 bits (189), Expect = 7e-13, Method: Compositional matrix adjust. Identities = 82/329 (24%), Positives = 141/329 (42%), Gaps = 30/329 (9%) Query: 13 LDPERAHEFTFQQ---LRRITGTP--FEALVRQKVPAKPVNCMG-LTFKNPLGLAAGLDK 66 + PERA T + L +I G P E + + P++ MG +TF P+GL AGLD Sbjct: 1 MPPERARSITLKSIGTLAKIPGGPSIIEWMGHMEPPSQLSKTMGPVTFPTPVGLGAGLDT 60 Query: 67 DGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVEN 126 + I AL GFG +E+G V+ P + + R + A + N G+ +L+ Sbjct: 61 ECIAIQALSKFGFGFLELGPVSKEPIVSHGTVQ--RDITAMNIHYSGHLVNNGIYSLLRR 118 Query: 127 VK-KAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINI-SSPNTPGLRTL 184 + A +G+ + +T + + ++ + K+ + I+ ++ P Sbjct: 119 LTGSAGIKIPIGVRLACQPETSLREATEELQELIGKLEHICSFFTIDTRANLGQPEWSHT 178 Query: 185 QYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIA 244 + E L Q DL P+ + I P LSE E + + S ++G++ Sbjct: 179 AWKEHFSCL-----RSQTDL--------PLLLAIPPSLSETEALPILTSAKEAGLNGLVV 225 Query: 245 TNTTLDRSLVQGMKNCDQTGGL-SGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIA 303 ++Q +C T +GR ++ + + + L IIG GG+ Sbjct: 226 AG-----GIIQEDSSCANTFVYTTGRSSHKQAVKFVSWTREQWPDAL-IIGSGGVLEPQD 279 Query: 304 AREKIAAGASLVQIYSGFIFKGPPLIKEI 332 A +AAGA VQ++SG ++ GP L K I Sbjct: 280 ALTFLAAGADFVQLHSGLVYSGPGLPKRI 308 >UniRef50_C0QU30 Dihydroorotate dehydrogenase, catalytic subunit (Dihydroorotate oxidase) (Dhodehase) (Dhodase) (Dhod) n=3 Tax=Hydrogenothermaceae RepID=C0QU30_PERMH Length = 320 Score = 77.0 bits (188), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 79/283 (27%), Positives = 136/283 (48%), Gaps = 39/283 (13%) Query: 50 MGLTFKNPLGLAAGLDKDG-ECIDALGAMG-FGSIEIGTVTPRPQPGNDKPRLFRLVDAE 107 G+ FKNP+ A+G G E L + G++ + ++ RP+ GN R+ Sbjct: 17 FGIKFKNPVWTASGCFSYGLEVAQNLYDISELGAVVVKGLSYRPREGNPPQRIVE--TPC 74 Query: 108 GLINRMGFNNLGVDNLVENV--KKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAY 165 G++N +G N GV+ ++N+ + YD V+ N+ + +D+YL E + Sbjct: 75 GMLNSIGLQNPGVEYFIKNILPQLREYDTVIVANV-------FGEDEDEYLKVAEVLNKA 127 Query: 166 AG--YIAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPD 221 G + +N+S PN G+ E L +L+ +K Q M P+ VK++P+ Sbjct: 128 DGVDLLELNVSCPNVKKGGIAFGSDPETLFNLVYRLK------QVMEK---PLLVKLSPN 178 Query: 222 LSEEELIQVADSLVRHNIDGVIATNTTLDRSL-------VQGMKNCDQTGGLSGRPLQLK 274 +++ ++ A + V DG++ NT L ++ + GM+ TGGLSG + Sbjct: 179 ITD--ILDTATASVEAGADGLVLINTLLGMAIDIDKEEPIIGMR----TGGLSGPAILPV 232 Query: 275 STEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQI 317 + +I ++ + +PIIGVGGI + A + I AGA VQI Sbjct: 233 AVRMIYQVYEKYGSSVPIIGVGGITTAQDALQHILAGAVSVQI 275 >UniRef50_A6DND8 Dihydroorotate dehydrogenase n=1 Tax=Lentisphaera araneosa HTCC2155 RepID=A6DND8_9BACT Length = 358 Score = 77.0 bits (188), Expect = 8e-13, Method: Compositional matrix adjust. Identities = 88/311 (28%), Positives = 141/311 (45%), Gaps = 57/311 (18%) Query: 46 PVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGN-------DKP 98 P GL F+N LG AAGLDKDG +D +G G +GTV +P GN ++ Sbjct: 53 PTELCGLKFRNDLGNAAGLDKDGSLLDFNYNLGAGFAVVGTVLDKPHTGNLFNAFGKERN 112 Query: 99 RLFRLVDAEGLINRMGFNNLGVDNLVENVKKAHYDGV------LGINIGKNKDTPVEQGK 152 L ++ +N +G +LGVD V+N+ KA D V +G++I + P ++G+ Sbjct: 113 PWAPLPNSHSALNSLGLPSLGVDVAVDNI-KAFQDRVQPQDFPIGVSIMGH---PAQEGE 168 Query: 153 ---DDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHH 209 L C++K A +I IN S PN G + A+ + ++A+ + D Sbjct: 169 VKLQGVLDCVKKSLPVADFIEINESCPNVKGHDS----SAMYERISAVMDVATD------ 218 Query: 210 KYVPIAVKIAP-DLSEEELIQVADSLVRHNIDGVIATNTTLDRSL-----------VQGM 257 VPI +K+ D +EE L + A+ + GV+ NT D V Sbjct: 219 -QVPIFIKLGSLDHAEEVLAKFAEM----KVAGVVLLNTQRDYDFYRPKLDKGDHKVFDF 273 Query: 258 KNCDQTGGLSGRPLQLKSTEIIRRLSLELNGR---LPIIGVGGI---DSVIAAREKIAAG 311 + +GGLSG ++ + + ++ + + L +I VGGI V +R+ Sbjct: 274 YTKEFSGGLSGTIIRQTALDAVKEAKAIIEQQKLDLKLIHVGGIGNNQDVCESRKY---- 329 Query: 312 ASLVQIYSGFI 322 A L + YS F+ Sbjct: 330 AELREWYSLFM 340 >UniRef50_Q0W8E1 Dihydroorotate dehydrogenase n=18 Tax=Euryarchaeota RepID=PYRD_UNCMA Length = 301 Score = 70.1 bits (170), Expect = 1e-10, Method: Compositional matrix adjust. Identities = 77/279 (27%), Positives = 125/279 (44%), Gaps = 30/279 (10%) Query: 48 NCMGLTFKNPLGLAAG-LDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDA 106 N GLT KNP LAAG L G + + +MG G++ ++ P+PG+ P + RL Sbjct: 6 NAGGLTLKNPTILAAGVLGTTGASLKRIASMGAGAVVTKSIGTEPKPGHHNPSMIRL--E 63 Query: 107 EGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYA 166 EG IN MG N + ++ A GV I + + + A Sbjct: 64 EGYINAMGLPNPSFGEFRQELEIARESGVPVI-------ASIFGATPEEFTAVANGLPGA 116 Query: 167 GYIAINISSPNTPGLRTLQYG---EALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLS 223 +N+S P+ G +Q G E + + A+K VP+ VK+ P+++ Sbjct: 117 DAYELNVSCPHAKGY-GMQCGTDPELVRSITKAVKAAVK---------VPVWVKLTPNVT 166 Query: 224 EEELIQVADSLVRHNIDGVIATNT--TLDRSLVQGMKNC-DQTGGLSGRPLQLKSTEIIR 280 + I +A D V+A NT + + G +++GGLSG ++ + + + Sbjct: 167 DIRPIGLAAQ--EGGADAVVAINTLKAMAIDINTGWPILGNRSGGLSGPAVKPVAIKCVY 224 Query: 281 RLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYS 319 L L+ +P+IGVGG+ + A E + AGA V+I S Sbjct: 225 DLYEVLD--IPVIGVGGVSNWADAIEFMMAGACAVEIGS 261 >UniRef50_A9BJH4 Dihydroorotate dehydrogenase n=45 Tax=Bacteria RepID=PYRD_PETMO Length = 300 Score = 68.6 bits (166), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 83/300 (27%), Positives = 139/300 (46%), Gaps = 34/300 (11%) Query: 47 VNCMGLTFKNPLGLAAGLDKDG-ECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVD 105 VN G+ FKNP+ A+G G E ++ G + +T R + GN R+ + Sbjct: 6 VNIAGVEFKNPVIAASGTFGFGREFLEYFPISKLGGLATKGLTLREREGNKGVRIHETIG 65 Query: 106 AEGLINRMGFNNLGVDNLVENVKK--AHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIY 163 G++N +G N G+D +E D V+ N+ N D+Y+I +EK+ Sbjct: 66 --GIMNSIGLQNPGIDAFIEEELPFLNSQDTVIIANVSGNT-------IDEYVISVEKLN 116 Query: 164 AY-AGYIAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAP 220 I +NIS PN G+ E +++T ++ + K P+ VK++P Sbjct: 117 QTDIDMIELNISCPNVKEGGISFGTKAEIASNVVTQVRK-------VCQK--PLIVKLSP 167 Query: 221 DLSEEELIQVADSLVRHNIDGVIATNT----TLDRSLVQGMKNCDQTGGLSGRPLQLKST 276 S E ++++A+S V D + NT +D S + + + + T GLSG ++ + Sbjct: 168 --SAENIVEMAESCVEAGADALSLVNTFPALAIDISKKKAIFD-NITAGLSGPCIKPIAL 224 Query: 277 EIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 ++ +S ++ +PIIG+GGI A E I AGA VQ+ + F P EI+ I Sbjct: 225 RMVYEVSKAVD--VPIIGIGGIMDYRDAIEYIMAGAWAVQVGTAN-FINPNACAEIIEGI 281 >UniRef50_C6A1L2 Dihydroorotate dehydrogenase family protein n=1 Tax=Thermococcus sibiricus MM 739 RepID=C6A1L2_THESM Length = 309 Score = 68.6 bits (166), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 83/279 (29%), Positives = 131/279 (46%), Gaps = 33/279 (11%) Query: 47 VNCMGLTFKNPLGLAAGLDKDG-ECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVD 105 ++ G+ F+NP+ LA+G G E + L G+I + TVT +P+ GN P RLVD Sbjct: 7 IDVFGIKFRNPIILASGPVGFGFELMPYLDFSNIGAITLKTVTLKPREGNPPP---RLVD 63 Query: 106 AE-GLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKI-- 162 + G+IN +G N G++ VE + + I IG + D++ I E++ Sbjct: 64 SHGGVINSIGLQNPGIEGFVEEI-APRLKELKTIKIGSIAGFSM----DEWEILGEEMDK 118 Query: 163 YAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDL 222 I IN+S PN G R L + + I K PI K+APD+ Sbjct: 119 IKEIKIIEINLSCPNVKGKRRWAEDAKLTEKVVKIVRKLTGK--------PIIAKLAPDV 170 Query: 223 SEEELIQVADSLVRHNIDGVIATN--TTLDRSLVQGMKNCD-QTGGLSG---RPLQLKST 276 + +++++A + V DG+ N + + G+ +TGGL G +P+ L Sbjct: 171 T--DIVEIAKTAVDAGADGLTIGNGAQAMRIDVETGLPILKLKTGGLGGPAVKPITLAKV 228 Query: 277 EIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLV 315 R +L+ +PIIG+GGI + A E AGASL+ Sbjct: 229 FKTRE-ALD----VPIIGIGGIMNWQDAIEYAMAGASLL 262 >UniRef50_C6QGW0 Dihydroorotate dehydrogenase n=1 Tax=Hyphomicrobium denitrificans ATCC 51888 RepID=C6QGW0_9RHIZ Length = 226 Score = 68.6 bits (166), Expect = 3e-10, Method: Compositional matrix adjust. Identities = 66/293 (22%), Positives = 115/293 (39%), Gaps = 73/293 (24%) Query: 50 MGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGL 109 MGL F NP+GLAAG D+ GE + A GFG +EIGT+ Sbjct: 1 MGLHFPNPIGLAAGFDRTGEHAPSPLASGFGHVEIGTINSEA------------------ 42 Query: 110 INRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYI 169 L ++ + LGINIG + + +D+ + + + +A Y+ Sbjct: 43 ------------GLATPLRHSANGARLGINIGSLRPGLDDLVIEDFEMRLRQAAPFADYV 90 Query: 170 AINISSP------NTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLS 223 N+++P N+PG +D L+ + ++++ P+ VK+ Sbjct: 91 VANLTAPAMQRSGNSPG---------VDQLMRRLSKVRDEISEARGSRTPLLVKLDGGAI 141 Query: 224 EEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLS 283 + + + + +DG++ + L R I +S Sbjct: 142 GDPIPAAVTAACVYGLDGIVLVSDRLRR---------------------------IEEIS 174 Query: 284 LELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + L +I VGGI + R ++ AGASLVQI+ F G L+ ++ + Sbjct: 175 NHMAA-LTLISVGGIQTAADIRARLVAGASLVQIHRAFADGGKQLLFRMLAEL 226 >UniRef50_Q3AC05 Dihydroorotate dehydrogenase n=1 Tax=Carboxydothermus hydrogenoformans Z-2901 RepID=PYRD_CARHZ Length = 307 Score = 68.2 bits (165), Expect = 4e-10, Method: Compositional matrix adjust. Identities = 84/294 (28%), Positives = 142/294 (48%), Gaps = 35/294 (11%) Query: 52 LTFKNPLGLAAGLDKDG-ECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLI 110 LT KNP+ A+G G E D G++ + T+T P+ GN PR++ + + G+I Sbjct: 10 LTLKNPVMPASGTFGFGLEFKDIFDLKNLGALVVKTITKNPRLGNRPPRVYEV--SCGMI 67 Query: 111 NRMGFNNLGVDNLVENV--KKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGY 168 N +G N G D E + + + +L +NI VE+ + YL + + Sbjct: 68 NSIGLANPGWDYFCEKILPQIKDLNDILILNIAGES---VEEFQ--YLAREAQRFDEIKA 122 Query: 169 IAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELI 228 + +N+S PN + G A L A+K + ++ ++ K + VK+ P++++ + Sbjct: 123 LELNVSCPNVS-----KGGIAFGTDLEALKQIVSSVRKIYSK--TLIVKLTPNVTD--IT 173 Query: 229 QVADSLVRHNIDGVIATNTTLDRSL-VQGMKNC--DQTGGLSG---RPLQLKST-EIIRR 281 A + D + NT + V+ K ++ GG+SG RP+ +K + + Sbjct: 174 VYAKAAENAGADALTLINTFTGMVIDVKSKKPILGNKHGGVSGPAIRPMAVKMVYDCFKA 233 Query: 282 LSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYS-GFIFKG--PPLIKEI 332 +S+ PIIGVGGIDS AA E AGA+ +Q+ S F+ G P LI+E+ Sbjct: 234 VSI------PIIGVGGIDSKEAALEFFLAGATAIQVGSQNFVEPGFMPRLIREL 281 >UniRef50_A0NIQ6 Dihydroorotate dehydrogenase A n=7 Tax=Lactobacillales RepID=A0NIQ6_OENOE Length = 329 Score = 66.2 bits (160), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 63/261 (24%), Positives = 113/261 (43%), Gaps = 23/261 (8%) Query: 80 GSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGIN 139 G++ + T + + GN +PR F IN MG NLG+D + V K + Sbjct: 57 GAVITKSATAKERSGNSEPRYFENSVEHNTINSMGLPNLGIDYYLNYVLKHSLKLPTLFS 116 Query: 140 IGKNKDTPVEQGKDDYLICMEKIYA--YAGYIAINISSPNTPGLRTLQYGEALDDLLTAI 197 I V + + + ++K+ A ++G +N+S PN PG + Y TA Sbjct: 117 I-------VGLSQSEIIDNLKKLQASGFSGLTELNLSCPNVPGKPQIAYD------FTAT 163 Query: 198 KNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQG- 256 + +++ A + K P+ VK+ P Q+A L + + V A N+ + ++ Sbjct: 164 REILDNVFAFYSK--PLGVKLPPYFDTAHFDQIASILNDYPLTYVNAINSVGNGLVIDPE 221 Query: 257 -----MKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAG 311 +K D GGL G+ ++ + +R L L ++ II GG+ + + + G Sbjct: 222 TDTPVIKPKDGFGGLGGKQIKATALANVRALRQRLYPQIKIIATGGVTNGRDVYDHLLCG 281 Query: 312 ASLVQIYSGFIFKGPPLIKEI 332 A L+ I S +GP + + Sbjct: 282 ADLISIGSQLEIEGPTVFARL 302 >UniRef50_D1JFH0 Dihydroorotate dehydrogenase electron transfer subunit/dihydroorotate dehydrogenase n=1 Tax=uncultured archaeon RepID=D1JFH0_9ARCH Length = 589 Score = 65.9 bits (159), Expect = 2e-09, Method: Compositional matrix adjust. Identities = 79/300 (26%), Positives = 129/300 (43%), Gaps = 31/300 (10%) Query: 32 TPFEALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRP 91 TP + P G+ F NP+ AAG G+ + G G++ +V Sbjct: 276 TPPARFTPEHEPELATEVCGIIFTNPIANAAGFGLSGKLLYRYAVAGAGAVVTKSVGLYE 335 Query: 92 QPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKKAHYDGV-LGINI-GKNKDTPVE 149 Q G P + +N MG N G+ + + A Y V L ++I GKN + E Sbjct: 336 QEGYPNPTFIEIA-PRSYVNAMGLPNPGIIDYGLEIGDAKYADVPLILSIFGKNVEECRE 394 Query: 150 QGK--DDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAM 207 K Y I M + N S P++ + A+++ +++ +++A+ Sbjct: 395 VAKIATKYPIDM---------LEFNASCPHSDFV-------AVENQPKLLRSIIKEIRAI 438 Query: 208 HHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSL-----VQGMKNCDQ 262 H PIAVKI+P++ + +A +L + D + A NT + R + + N Sbjct: 439 VHPK-PIAVKISPNVGDPA--GLAMTLEKAGADAITAINTVIARPVDNRLDTHILGNPTG 495 Query: 263 TGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFI 322 GG SG+ L + EI+ L EL ++PII VGGI S + GAS+ Q+ S + Sbjct: 496 YGGKSGKDLTVGGKEIVFNLYKEL--KIPIIAVGGIFSAKDVIDYAKNGASMFQVGSALV 553 >UniRef50_Q1G992 Dihydroorotate dehydrogenase n=3 Tax=Lactobacillus delbrueckii RepID=Q1G992_LACDA Length = 309 Score = 65.1 bits (157), Expect = 4e-09, Method: Compositional matrix adjust. Identities = 75/283 (26%), Positives = 133/283 (46%), Gaps = 32/283 (11%) Query: 47 VNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDA 106 V GL KNP+ A+G G+ + G+I + T T + GN +P++ L D Sbjct: 9 VELPGLKLKNPVMPASGTFAFGDLPENFNWDEMGAIVLKTATRHARTGNPQPQIDLLAD- 67 Query: 107 EGLINRMGFNNLGVDNL----VENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKI 162 G++N +G N G + + + +++ H D + ++G + +DY+ E + Sbjct: 68 -GVMNAVGLTNPGAEVVASEKIPALREKHPDLPILASVGG-------ESVEDYVEVAEIL 119 Query: 163 YAYA-GYIAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIA 219 A + +N+S PN G+ E L+ + +K K + +P+ VK+ Sbjct: 120 AAAKPDALELNLSCPNVSEGGMTFGIVPEMLEKITRLVKEKVD---------LPVYVKLT 170 Query: 220 PDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKN---CDQTGGLSGRPLQLKST 276 P+++ ++++A + DG+ NT L L + + GGL G+ ++ + Sbjct: 171 PNVTS--IVEIAQAAEGGGADGLTLINTLLVLHLDLKTRRPVLGNDFGGLYGQAVKPVAV 228 Query: 277 EIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYS 319 ++ ++ + LPIIGVGGI+S A E I AGAS VQI S Sbjct: 229 RMVAQVKQATS--LPIIGVGGINSPEDAAEFILAGASAVQIGS 269 >UniRef50_C6SRR7 Putative dihydroorotate dehydrogenase dihydroorotate oxidase n=1 Tax=Streptococcus mutans NN2025 RepID=C6SRR7_STRMN Length = 330 Score = 64.3 bits (155), Expect = 6e-09, Method: Compositional matrix adjust. Identities = 75/298 (25%), Positives = 127/298 (42%), Gaps = 37/298 (12%) Query: 54 FKNPLGLAAGLD-KDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAE-GLIN 111 F N L AAG+ E + A+ GS T T + GN +PR D + G IN Sbjct: 32 FDNCLMNAAGVYCMTREELAAIDHSEAGSFVTKTGTLEERAGNPQPRY---ADTKLGSIN 88 Query: 112 RMGFNNLGVDNLVENV--------KKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIY 163 MG NLG++ ++ V K H+ ++G+ +P E ++ M + Sbjct: 89 SMGLPNLGINYYLDYVTELQKQPDSKNHFLSLVGM-------SPEETHT---ILKMVEAS 138 Query: 164 AYAGYIAINISSPNTPGLRTLQYG-EALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDL 222 Y G + +N+S PN PG + Y E D +L+ + + P+ +K+ P Sbjct: 139 KYQGLVELNLSCPNVPGKPQIAYDFETTDQILSEV---------FTYFTKPLGIKLPPYF 189 Query: 223 SEEELIQVADSLVRHNIDGVIATNTTLDRSLVQG----MKNCDQTGGLSGRPLQLKSTEI 278 Q A ++ + V N+ + +++ +K + GG+ G ++ + Sbjct: 190 DIVHFDQAAAIFNKYPLTFVNCINSIGNGLVIEDETVVIKPKNGFGGIGGDYVKPTALAN 249 Query: 279 IRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + LN + IIG GG+ + A E I GAS+VQI + +GP + K I + Sbjct: 250 VHAFYKRLNPSIQIIGTGGVKTGRDAFEHILCGASMVQIGTALHQEGPQIFKRITKEL 307 >UniRef50_Q1Q4L5 Similar to dihydroorotate oxidase (Dihydroorotate dehydrogenase B) catalytic subunit n=1 Tax=Candidatus Kuenenia stuttgartiensis RepID=Q1Q4L5_9BACT Length = 306 Score = 63.9 bits (154), Expect = 8e-09, Method: Compositional matrix adjust. Identities = 76/293 (25%), Positives = 136/293 (46%), Gaps = 40/293 (13%) Query: 47 VNCMGLTFKNPLGLAAG-LDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVD 105 +N + NP LA+G L + + G G++ I +V+ + G+ P + Sbjct: 8 INLCSMRLSNPTVLASGILGTTKTLLKRVAESGAGAVTIKSVSKDSREGHHNPTVITY-- 65 Query: 106 AEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAY 165 G++N +G++N GV+ + GV I + + DD++ E + A Sbjct: 66 EAGMLNAVGYSNPGVEAARIEYSNLNEIGVPVI------ASIIGTCTDDFIEVAEGLSA- 118 Query: 166 AGYIAINI--SSPNTPGLRTLQ---YGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAP 220 +G+ AI I S P+TPG L +A ++ A++ K N VPI VKI+P Sbjct: 119 SGFSAIEIPLSCPHTPGFGLLSGQGTPKATYEITYAVRRKTN---------VPIFVKISP 169 Query: 221 DLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCD-----QTGGLSG---RPLQ 272 ++ E+ +A + +G+ A N+ + +V +++ + GG++G RP+ Sbjct: 170 NV--PEITSIAKAAEDAGANGITAVNS-MGPGMVINIESKKPVLGFKVGGVTGDALRPIA 226 Query: 273 LKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKG 325 ++ + + ++PIIGVGGI + A E + AGAS V I +G +G Sbjct: 227 VRCVYDVYQAV-----KIPIIGVGGISTGRHAIEMMMAGASAVGIGTGVYTRG 274 >UniRef50_A5IK84 Dihydroorotate dehydrogenase n=10 Tax=Thermotogaceae RepID=PYRD_THEP1 Length = 270 Score = 63.5 bits (153), Expect = 9e-09, Method: Compositional matrix adjust. Identities = 77/291 (26%), Positives = 134/291 (46%), Gaps = 41/291 (14%) Query: 52 LTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEG-LI 110 L K PL L +G GE + + G + + TVT P+ GN P R+ D++ +I Sbjct: 2 LELKPPLVLLSGPAGFGEYLKLMDHRYVGGVLLKTVTLHPKEGNPTP---RMADSDFYVI 58 Query: 111 NRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIA 170 NR+G N G+ VEN+ + + + G + + +E + + ++ YA + Sbjct: 59 NRIGLENPGIHAFVENIPELPVPMIASLG-GDSFEEYLEVAR-VFKKVADRFYA----VE 112 Query: 171 INISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELI 228 N S PN GL ++ E LL ++ K +P + IA E + Sbjct: 113 FNFSCPNVKEGGLSIVKNAEEWKKLLNTLR-----------KELPDSFLIAKVGVEGIFV 161 Query: 229 Q-VADSLVRHNIDGVIATNTTLDRSLVQGM---KNCDQTGGLSG---RPLQLKSTEIIRR 281 + A+ +++ DG+ NT V+G+ K+ GGLSG +P+ L++ +++ Sbjct: 162 EDAAEFVMKTGWDGITLVNT------VRGLHFEKDTMILGGLSGPVLKPIALRAVYEVKK 215 Query: 282 LSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 EL +I GG+ SV A E + GA ++ + S +FK P +++EI Sbjct: 216 RFPELF----VIASGGVYSVKDAEEFLKVGADVIGVGSA-LFKDPGVVEEI 261 >UniRef50_B1MZ73 Dihydroorotate dehydrogenase B, catalytic subunit n=1 Tax=Leuconostoc citreum KM20 RepID=B1MZ73_LEUCK Length = 306 Score = 63.2 bits (152), Expect = 1e-08, Method: Compositional matrix adjust. Identities = 70/284 (24%), Positives = 129/284 (45%), Gaps = 45/284 (15%) Query: 51 GLTFKNPL-----GLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVD 105 GL KNP+ + GL+ G I+ GA+ TVT + GN +P + Sbjct: 12 GLDLKNPIMNSSGAVFFGLEDKGYAIEETGAL-----VTKTVTMSARAGNPQPWIIN--T 64 Query: 106 AEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPV-----EQGKDDYLICME 160 G++N +G N G++ +V ++ A ++ K K PV + +Y+ E Sbjct: 65 PSGILNSVGLANPGIEAVVADILPAIHE--------KYKTLPVLASVAGETVGEYVALTE 116 Query: 161 KIYAYAGYIAI--NISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAV 216 ++ A AI N+S PN G+ E+ +++ A++ +PI Sbjct: 117 RLTATKQVTAIEANLSCPNVDRGGMAFGVTAESAAEVIHAMRAATT---------LPIYA 167 Query: 217 KIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSL---VQGMKNCDQTGGLSGRPLQL 273 K++P++++ + + ++ DG++ NT + SL + + TGG+SG + Sbjct: 168 KMSPNVTD--IKPIVKAVETAGADGIVLINTVVGMSLDLNTRQARLARGTGGMSGTSVHP 225 Query: 274 KSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQI 317 + + + ++ +P+IGVGG+ +V E + AGAS VQI Sbjct: 226 IAVRFVYETAQTVS--IPVIGVGGVSTVDDVLELMMAGASAVQI 267 >UniRef50_B5YJH1 Dihydroorotate dehydrogenase n=24 Tax=Bacteria RepID=PYRD_THEYD Length = 303 Score = 62.8 bits (151), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 79/291 (27%), Positives = 138/291 (47%), Gaps = 42/291 (14%) Query: 42 VPAKPVNCMGLTFKNPLGLAAGLDKDG-ECIDALGAMGFGSIEIGTVTPRPQPGNDKPRL 100 +P V L+FKNP+ A+G G E + G I + ++ +P+ GN PR+ Sbjct: 1 MPVLEVKIGNLSFKNPVLTASGTFGYGLEYSQFVDLNILGGIVVKGLSLKPKQGNPPPRI 60 Query: 101 FRLVDAEGLINRMGFNNLGVDNLVEN----VKKAHYDGVLGINIGKNKDTPVEQGKDDYL 156 + G+IN +G N+G++ + +KK + + ++ G+N D +E K L Sbjct: 61 YE--TPCGMINSIGLQNIGLEAFKKEKLPFLKKFNTNIIVNF-FGENLDEYIEVAK--LL 115 Query: 157 ICMEKIYAYAGYIAINISSPN-TPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIA 215 E ++A + +N+S PN T R + G + L AIK + H P+ Sbjct: 116 DETEGVHA----LEMNVSCPNKTSEWRKM--GLEPELLREAIK------RVRLHIKKPLI 163 Query: 216 VKIAPDLSEEELI------QVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSG- 268 VK+AP ++E L+ + AD++ N + + +S++ + TGGLSG Sbjct: 164 VKLAPQVTEIALMARICEEEGADAVSLINTIPAMVIDIKTRKSMIGTL-----TGGLSGP 218 Query: 269 --RPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQI 317 RP+ L++ + + ++P+IGVGGI S A + + AGA +Q+ Sbjct: 219 AIRPVALRAVWEVAQAV-----KIPVIGVGGIVSAEDALQFLIAGAKAIQV 264 >UniRef50_O27281 Dihydroorotate dehydrogenase n=20 Tax=Euryarchaeota RepID=PYRD_METTH Length = 303 Score = 62.8 bits (151), Expect = 2e-08, Method: Compositional matrix adjust. Identities = 72/297 (24%), Positives = 133/297 (44%), Gaps = 46/297 (15%) Query: 52 LTFKNPLGLAAG-LDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLI 110 + +NP LAAG + ++ + G G++ + + RP PG P + G+I Sbjct: 12 IELRNPTILAAGVMGSMASSLNRIYRGGAGAVVTKSFSLRPNPGYRNPTTVEVTG--GVI 69 Query: 111 NRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIA 170 N +G +N GV+ E +K + L ++ +++ + YA I Sbjct: 70 NAIGLSNPGVEAFREELKLVDEEVPLIASV-------YGASPEEFASAAASVEEYADMIE 122 Query: 171 INISSPNT---PGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEEL 227 +N+S P+ G Q E +++A+K+ + VPI+ K+ P++++ + Sbjct: 123 LNVSCPHAMAGCGASIGQDPELTFRVVSAVKDAVD---------VPISTKLTPNVTD--I 171 Query: 228 IQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQT---------GGLSG---RPLQLKS 275 +++A S D + TL SL GMK +T GG+SG +P+ ++ Sbjct: 172 VEIAGSAEEAGSDAL-----TLINSLGPGMKIDIKTARPILSNAFGGMSGPAIKPVAVRC 226 Query: 276 TEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 + R + +PI+GVGG+ A E + AGA VQ+ + ++ GP + +I Sbjct: 227 VYDVYR-----SVDIPIMGVGGVRDFQDAVEFLFAGARAVQVGTAIMYDGPEVFMKI 278 >UniRef50_C2D6B3 Dihydroorotate oxidase n=1 Tax=Atopobium vaginae DSM 15829 RepID=C2D6B3_9ACTN Length = 309 Score = 62.0 bits (149), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 74/284 (26%), Positives = 123/284 (43%), Gaps = 36/284 (12%) Query: 47 VNCMGLTFKNPLGLAAGLDKDGECIDALGAMG-FGSIEIGTVTPRPQPGNDKPRLFRLVD 105 VN G+ KNP+ AAG G+ + + G+I + +P GN PR+ + Sbjct: 10 VNLGGIHMKNPVNTAAGTFAFGQQFEKFYDVSQLGAITTKGASIKPWAGNPAPRMCEVTS 69 Query: 106 AEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPV-----EQGKDDYLICME 160 G+IN +G N GV+ L+ N A+ G+ + K+ V D+Y+ +E Sbjct: 70 --GIINSVGLQNPGVNGLI-NTAGAYLTGL------QQKNCQVICQVAGHSIDEYVAALE 120 Query: 161 KIYAYAGYIA---INISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVK 217 A + A INIS PN G A+ L+ + + P+ VK Sbjct: 121 VFEEKASFAAGFEINISCPNI-----ACGGAAMGSTPQGAAEIMRRLRPLTKR--PLLVK 173 Query: 218 IAP----DLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQL 273 + P +++ + AD+L N +A +TT +S K TGG SG + Sbjct: 174 MGPVNIPEIARALESEGADALSLINSIPGMAIDTTTYKS-----KLSRPTGGFSGPAIHP 228 Query: 274 KSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQI 317 + ++ + ++P+ G+GGI + + A E I AGA+ V + Sbjct: 229 IAVRMVWEAHKAV--KIPLCGIGGITTGLEAAEFILAGATAVSV 270 >UniRef50_Q73P17 Dihydroorotate dehydrogenase/oxidoreductase, FAD-binding n=1 Tax=Treponema denticola RepID=Q73P17_TREDE Length = 591 Score = 61.6 bits (148), Expect = 3e-08, Method: Compositional matrix adjust. Identities = 61/260 (23%), Positives = 118/260 (45%), Gaps = 25/260 (9%) Query: 70 CIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVK- 128 C D LG FG + + P PGN +P L + N +G N G++ V+ +K Sbjct: 44 CADELG---FGLVTTKSFQVLPNPGNREPILCE-PELGCFGNSVGLRNCGMEQAVKELKE 99 Query: 129 -KAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYG 187 ++ + +N+ + P +D++ ++ A +N S P+ + +G Sbjct: 100 LRSSWKTDSILNVSLSASNP-----EDFISLLKGFEELADCFELNFSCPHA----SAGFG 150 Query: 188 EALD-DLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATN 246 ++ D A + + +A+ VPI VK+ P++ E++ +A +++ DG+ A N Sbjct: 151 ASIGCDPAIAAEYVKIIKKALPDCAVPIFVKLTPNV--EDIGAIASAVIEAGADGITAIN 208 Query: 247 TTLDRSLVQG-------MKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGID 299 T + ++ GG+SG + ++ E I ++ + +PIIG+GG+ Sbjct: 209 TVGPKVYIEPHSGKPILQNKLGGKGGMSGAWVFPRALECIGQIRKAVGEEIPIIGMGGVM 268 Query: 300 SVIAAREKIAAGASLVQIYS 319 + A E + AGA ++ I S Sbjct: 269 TGAQAAELVRAGADIIGIGS 288 >UniRef50_A9A3M4 Dihydroorotate dehydrogenase family protein n=2 Tax=Thaumarchaeota RepID=A9A3M4_NITMS Length = 303 Score = 61.6 bits (148), Expect = 4e-08, Method: Compositional matrix adjust. Identities = 70/275 (25%), Positives = 124/275 (45%), Gaps = 35/275 (12%) Query: 57 PLGLAAGLDKDGECIDALGAM---GFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRM 113 P+ LA+G+ G +D + G G++ +++ P G P +F V G IN + Sbjct: 17 PVMLASGIL--GISLDVFSRLYRSGAGAVVTKSLSTEPWEGYPNPTIFS-VKGGGWINAV 73 Query: 114 GFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINI 173 G +N G +N + ++ + D + +++ + E+ + C K+ AY +N+ Sbjct: 74 GLSNPGAENFAKMIEP-NQDVPIIVSLVGSIPEDFEKMIKQFENC--KVTAYE----LNL 126 Query: 174 SSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVA 231 S P+ GL E + ++T +KN N VP+ K+ L + Sbjct: 127 SCPHVAKVGLEVGDDPELVKKIVTTVKNSTN---------VPVIAKVG--LGTTHYLNTV 175 Query: 232 DSLVRHNIDGVIATNTTLDRSLVQGMKN-----CDQTGGLSGRPLQLKSTEIIRRLSLEL 286 + + ID + A NT RS+ ++ ++ GGLSG P++ + + +S + Sbjct: 176 GTAIESGIDAITAINTV--RSMAIDVETQRPILSNKFGGLSGTPIKPIALRCVYEISSKY 233 Query: 287 NGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGF 321 + +PIIG GGI + A E AGAS VQ+ S Sbjct: 234 D--IPIIGCGGISTWEDAVEFFLAGASSVQLGSAI 266 >UniRef50_Q0B324 Dihydroorotate oxidase B, catalytic subunit n=8 Tax=Proteobacteria RepID=Q0B324_BURCM Length = 325 Score = 61.2 bits (147), Expect = 5e-08, Method: Compositional matrix adjust. Identities = 75/288 (26%), Positives = 135/288 (46%), Gaps = 28/288 (9%) Query: 52 LTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDA-EGLI 110 L +NP+ A+G E DAL G G++ I +V+P +PGN PR+ DA +G++ Sbjct: 11 LRLRNPVMPASGCFAI-EYRDALDLTGLGALVIKSVSPVSRPGNPTPRV---ADAGDGML 66 Query: 111 NRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIA 170 N +G + G+D+ +E+V A+ + + DT + + + A I Sbjct: 67 NSIGIPSRGIDDYLEHVLPAYTGHGTPVVASVSADTADAFARACEALSRPDVAA----IE 122 Query: 171 INISSPN--TPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELI 228 NIS PN G+ ++ AI+ + P+ VK+ P+ + Sbjct: 123 ANISCPNLEADGMAFGMDAGMTRQVVDAIRTRTGH---------PLWVKLTPNAGN--IA 171 Query: 229 QVADSLVRHNIDGVIATNTTLDRSL-VQGMKNC--DQTGGLSGRPLQLKSTEIIRRLSLE 285 ++A + D ++ NT L S+ V+ + + GGLSG ++ + ++ + Sbjct: 172 KIAQAAQDAGADAIVMGNTVLGMSIDVRTRRPSLGNVMGGLSGPSIKPIALRLVHQCYRA 231 Query: 286 LNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIV 333 ++ +P+IG GGI S A E + AGAS VQ+ + F+ P +++ I+ Sbjct: 232 VS--IPVIGCGGIRSAADAIEFLLAGASAVQVGTAS-FRDPGVMRTII 276 >UniRef50_D1YYV3 Dihydroorotate dehydrogenase n=1 Tax=Methanocella paludicola SANAE RepID=D1YYV3_METPS Length = 315 Score = 60.8 bits (146), Expect = 6e-08, Method: Compositional matrix adjust. Identities = 74/280 (26%), Positives = 119/280 (42%), Gaps = 30/280 (10%) Query: 47 VNCMGLTFKNPLGLAAG-LDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVD 105 V GLT NP LAAG L G + + +MG G++ ++ P+ G+ P + RL Sbjct: 14 VEAGGLTLTNPTILAAGILGTTGASLKRVASMGAGAVVTKSIGAEPKYGHPNPSMIRL-- 71 Query: 106 AEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAY 165 G IN MG N + ++ A GV I + + I + K Sbjct: 72 ECGYINAMGLPNPSYKEFLPELETAKDSGVPVI-------ASIFGATEAEFIEVAKGLPG 124 Query: 166 AGYIAINISSPNTPGLRTLQYG---EALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDL 222 A +N+S P+ G +Q G + + A+K N P+ VK+ P++ Sbjct: 125 ASAYELNVSCPHARGYG-MQVGTDPALVKAIAHAVKGTVN---------APVWVKLTPNV 174 Query: 223 SEEELIQVADSLVRHNIDGVIATNT--TLDRSLVQGMKNCDQT-GGLSGRPLQLKSTEII 279 ++ + + + D V+A NT + + G GGLSG ++ + + Sbjct: 175 TD--ITSIGRAAQEGGADAVVAINTLKAIAIDIDSGYPILGNIQGGLSGPAIKPVAVRCV 232 Query: 280 RRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYS 319 L L+ +P+IG GG+ S A E I AGA+ V+I S Sbjct: 233 YDLYSALD--IPVIGAGGVSSWADAVEFIMAGAAAVEIGS 270 >UniRef50_B1I4M6 Dihydroorotate dehydrogenase n=73 Tax=Bacteria RepID=PYRD_DESAP Length = 307 Score = 60.5 bits (145), Expect = 8e-08, Method: Compositional matrix adjust. Identities = 78/285 (27%), Positives = 135/285 (47%), Gaps = 40/285 (14%) Query: 47 VNCMGLTFKNPLGLAAGLDKDGE-CIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVD 105 V GLT KNP+ A+G GE L G G++ + TVT +P+ GN PR+ Sbjct: 7 VAIAGLTLKNPVLTASGTVGFGEEYAPYLDLAGLGALVVKTVTLKPRAGNPPPRITE--T 64 Query: 106 AEGLINRMGFNNLGVDNLVENV--KKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIY 163 G+IN +G N GV+ LV ++ + A +D + ++I + D+Y ++ Sbjct: 65 PAGVINAVGLQNPGVEALVRDILPRLARFDVPVIVSIAG-------ETVDEYARLAGRLD 117 Query: 164 AYAGYIA--INISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPD 221 G A +NIS PN + +G + +TA + Q + +P+ K++P+ Sbjct: 118 GVPGIAALEVNISCPNVKA-GGIAFGT--EPAMTAAVVR----QVRENTRLPVIAKLSPN 170 Query: 222 LSEEELIQVADSLVRHNIDGVIATNTTL------DRSLVQGMKNCDQTGGLSG---RPLQ 272 +++ I +A + + +I T + + R L+ + GGLSG RP+ Sbjct: 171 VTDIRTIALAAAGAGADALSLINTLSAMVIDVERRRPLL-----GNVFGGLSGPAVRPVA 225 Query: 273 LKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQI 317 +++ + + ++E LP+IG+GGI + A E I AGA V + Sbjct: 226 VRAVWQVYQ-AVE----LPLIGMGGIMTARDALEFILAGARAVAV 265 >UniRef50_A4WLH6 Dihydroorotate dehydrogenase n=5 Tax=Thermoproteaceae RepID=A4WLH6_PYRAR Length = 297 Score = 60.5 bits (145), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 59/213 (27%), Positives = 90/213 (42%), Gaps = 37/213 (17%) Query: 41 KVPAKPVNCMG------LTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPG 94 +P P C G + P+G+AAGLDK G L G I +G+ PRP+ G Sbjct: 28 SLPLPPCKCEGGWEVGGVKICGPVGIAAGLDKTGMYARFLSFFCPGFIVVGSTLPRPRRG 87 Query: 95 NDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDD 154 N PR+ R V ++N MG N+ G+ +V + Y + I D V+ Sbjct: 88 NKPPRVAR-VWPYSMVNAMGLNSPGLPRVVSRISNLKYPVFVSIAGFSAGDFAVQ----- 141 Query: 155 YLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPI 214 L + + Y A + +NISSP G + LD + D +PI Sbjct: 142 -LAYLRRYYKPAA-VELNISSPTYRGF--WRVAPELDGV---------D--------IPI 180 Query: 215 AVKIAPDLSEEELIQVADSLVRHNIDGVIATNT 247 +K+ P + E ++ A V+ G++ TNT Sbjct: 181 FLKVGPSVDLREAVRQA---VKAGW-GLVVTNT 209 >UniRef50_C0WNB5 Dihydroorotate dehydrogenase n=3 Tax=Lactobacillus RepID=C0WNB5_LACBU Length = 315 Score = 60.5 bits (145), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 73/266 (27%), Positives = 115/266 (43%), Gaps = 45/266 (16%) Query: 86 TVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLV----ENVKKAHYDGVL---GI 138 + TP+P+ GN+ PR+ G IN MG N G+D + EN +K +L G+ Sbjct: 50 SATPQPREGNESPRM--KATPLGCINSMGLPNHGLDYYLKFAEENQRKNDNQVILSIAGL 107 Query: 139 NIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYG-EALDDLLTAI 197 ++ +N + + Q +D + G +N+S PN G + Y EA+ D+LT Sbjct: 108 SVDQNLEM-LHQIQDSL---------FDGLTELNLSCPNIKGESQIAYDFEAVRDILT-- 155 Query: 198 KNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGM 257 +A I +K+ P + Q+AD L I V + N S+ G+ Sbjct: 156 -------KAFDFFTKDIGIKLPPYFDLHQFDQIADVLNEFPIAYVNSIN-----SIGNGL 203 Query: 258 KNCDQTGGLSGRPLQ---------LKSTEI--IRRLSLELNGRLPIIGVGGIDSVIAARE 306 +T + +P +K T + +R L L L + IIG GGI S E Sbjct: 204 IVNPETESVVLKPKGGFGGLGGDYVKPTALANVRGLRLRLKPEIAIIGTGGIKSGRDVFE 263 Query: 307 KIAAGASLVQIYSGFIFKGPPLIKEI 332 I GA++VQI + F F+ + I Sbjct: 264 HILCGANVVQIGTAFGFEDVKIFDRI 289 >UniRef50_Q2NEG1 PyrD n=1 Tax=Methanosphaera stadtmanae DSM 3091 RepID=Q2NEG1_METST Length = 306 Score = 60.5 bits (145), Expect = 9e-08, Method: Compositional matrix adjust. Identities = 75/303 (24%), Positives = 135/303 (44%), Gaps = 45/303 (14%) Query: 50 MGLTFKNPLGLAAG-LDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEG 108 +G+ NPL LAAG L + + G G I + + G D P + ++ G Sbjct: 7 LGMKLSNPLFLAAGILGTTASSMKMVARAGAGGIVTKSFSIEANDGYDNPTIVKI--EGG 64 Query: 109 LINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPV-----EQGKDDYLICMEKIY 163 +IN +G + GV+ E +K +N ++K TPV ++ + + Sbjct: 65 VINSVGLASPGVEAKKEELKD--------LNEIRDK-TPVIASIYGDSEEVFSDVANQTK 115 Query: 164 AYAGYIAINISSPNTP---GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAP 220 Y +N+S P+ G + E D+++++K+ D VPI VK+ P Sbjct: 116 DYVDAFELNVSCPHAKCGFGSNIGENPELTHDIVSSVKDNIKD--------VPIIVKLTP 167 Query: 221 DLSEEELIQVADSLVRHNIDGVIATNTT-----LDRSLVQGMKNCDQTGGLSG---RPLQ 272 ++++ + ++A + D + N+ +D + + N + GG++G +P+ Sbjct: 168 NVTD--ITEIAKAAEDAGADALTLINSVGPGLRIDYKTARPILN-NVFGGIAGPMIKPIA 224 Query: 273 LKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 LK +P+ GVGGI + A E + AGASL+QI + +++GP + K I Sbjct: 225 LKCVYKTYETV-----DIPLFGVGGIRTYKDALEFLYAGASLLQIGTSIMYEGPEIFKNI 279 Query: 333 VTH 335 TH Sbjct: 280 -TH 281 >UniRef50_C1A4J6 Dihydroorotate dehydrogenase n=1 Tax=Gemmatimonas aurantiaca T-27 RepID=C1A4J6_GEMAT Length = 327 Score = 59.7 bits (143), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 81/289 (28%), Positives = 132/289 (45%), Gaps = 44/289 (15%) Query: 47 VNCMGLTFKNPLGLAAGLDKDG-ECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVD 105 V+ GL F+NP+ LA+G G E D L G I V+ P+PGN R+ Sbjct: 24 VSVAGLAFRNPVVLASGTAGFGQELEDVLDLSAVGGISTKAVSVAPRPGNPALRVSEF-- 81 Query: 106 AEGLINRMGFNNLGVDNLVEN---VKKAHYDGV-LGINIGKNKDTPVEQGKDDYLICMEK 161 A G++N +G N G++++ + AH+ G + +N+ V +D+ + Sbjct: 82 AGGMMNAIGLANPGLESVRRDYLPWLPAHHPGTRVFVNV-------VGNSIEDFATVVRG 134 Query: 162 IYAYAGYIA--INISSPNTPGLRTLQYG---EALDDLLTAIKNKQNDLQAMHHKYVPIAV 216 + G A +N+S PN L++G +AL L++A + PI V Sbjct: 135 LDDVPGVDAFELNVSCPNVKA-GGLEFGADPQALHALVSAARGATKR---------PIFV 184 Query: 217 KIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQ--------TGGLSG 268 K++P L +AD+ R +D AT TL ++ + + D+ +GG+SG Sbjct: 185 KLSPTLGA----AIADT-ARVAVD-AGATGLTLVNTMPGTVIDTDRRRPKLSFGSGGVSG 238 Query: 269 RPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQI 317 L R+S L +P+IG+GGI + A + + AGASLV + Sbjct: 239 PALLPVGLLATWRVSRALP-TVPLIGLGGISTGDDALQYLMAGASLVGV 286 >UniRef50_C8W700 Dihydroorotate dehydrogenase family protein n=2 Tax=Atopobium RepID=C8W700_ATOPD Length = 308 Score = 59.7 bits (143), Expect = 1e-07, Method: Compositional matrix adjust. Identities = 73/289 (25%), Positives = 124/289 (42%), Gaps = 34/289 (11%) Query: 47 VNCMGLTFKNPLGLAAGLDKDGECIDALGAMGF-GSIEIGTVTPRPQPGNDKPRLFRLVD 105 VN G+ KNP+ AAG G + + G+I + V P GN PR+ L Sbjct: 9 VNLGGIQMKNPINTAAGTFGYGWQFEGFYDVSLLGAITMKGVARVPWEGNPAPRMCEL-- 66 Query: 106 AEGLINRMGFNNLGVDNLVENVKKAHYDGVL------GINIGKNKDTPVEQGKDDYLICM 159 G++N +G N GVD+ + AH D + G + Q D + + Sbjct: 67 NGGMMNSVGLANPGVDDFI-----AHTDDYMKDLEDRGTRVIMQMAAHSVQEMIDVVERL 121 Query: 160 EKIYAYAGYIAINISSPN-TPGLRTLQ-YGEALDDLLTAIKNKQNDLQAMHHKYVPIAVK 217 E++ + I +N+S PN G R L E +++ A++ +PI VK Sbjct: 122 EELNPHISAIELNVSCPNLEKGGRPLGGTPEQATEIMKAVRPLTK---------LPILVK 172 Query: 218 IAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSL---VQGMKNCDQTGGLSGRPLQLK 274 +AP + ++ + DG+ N+ S+ + + TGGLSG Sbjct: 173 MAP----VNVAEIGKAFEAEGADGLTLINSIPGMSINVHTRKSRLSKPTGGLSGPLCHNA 228 Query: 275 STEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIF 323 + ++ + ++ +PI GVGG+++ A E I AGA+ V + S ++ Sbjct: 229 AVRMVWECAQAVS--IPICGVGGVETGEDAAEFILAGATAVSVGSANLY 275 >UniRef50_Q8TXU6 Dihydroorotate dehydrogenase n=1 Tax=Methanopyrus kandleri RepID=Q8TXU6_METKA Length = 318 Score = 59.7 bits (143), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 69/281 (24%), Positives = 120/281 (42%), Gaps = 18/281 (6%) Query: 45 KPVNCMGLTFKNPLGLAAG-LDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRL 103 +PV +G + +P+ A+G L ++ G +I TVT P+ G+ P Sbjct: 2 RPVEVLGKRWAHPIACASGALAAHRPGMENAVLRGAAAIFTKTVTESPREGHPGPVFVDY 61 Query: 104 VDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIY 163 +D +N MG N G D +V +++ + + + D P + + Sbjct: 62 LDEGYALNAMGLPNPGPDRMVVEIEEFRDEFDVPVYASVAADGP-----EGFKRLARAFS 116 Query: 164 AYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLS 223 A + +N+S P+ YG L A+ A+ P++VK+ P++ Sbjct: 117 GVADGLELNVSCPHA----GKGYGAELGSDPEAVAEITE--AAVRAFDGPVSVKLTPNVD 170 Query: 224 EEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQT-----GGLSGRPLQLKSTEI 278 E L++VA + + + + A NT L L ++ GGLSG L+ + + Sbjct: 171 RETLLEVAAAAIDAGAEALTAVNT-LGPGLRIDLRTASPVLGAGVGGLSGPALKPIALRV 229 Query: 279 IRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYS 319 + L+LE + IIGVGGI + E + AGA VQ+ + Sbjct: 230 VADLALEFGEEVEIIGVGGIRNGEDVVEFLFAGAKAVQVAT 270 >UniRef50_B5YFH3 Dihydroorotate dehydrogenase n=2 Tax=Dictyoglomus RepID=B5YFH3_DICT6 Length = 306 Score = 59.3 bits (142), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 76/295 (25%), Positives = 131/295 (44%), Gaps = 30/295 (10%) Query: 52 LTFKNPLGLAAGLDKDGECIDALGAM-GFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLI 110 L FKNP+ LA+G +G I+ + G G ++T P+ GN PR++ G++ Sbjct: 11 LIFKNPILLASGTCGNGREINKFYDINGLGGFVTKSITLNPREGNPPPRIWE--SYAGIL 68 Query: 111 NRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIA 170 N +G N+G+ +E ++ + L N+ E+ ++ Y I + Sbjct: 69 NSIGLENVGLQKFLE--EEMPFLERLSTNV--IVSIAGEKKEEYYEIARNLRGCKISGVE 124 Query: 171 INISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQV 230 +N+S PN G L +G +D + K+ + + P+ VK+ P ++++++ Sbjct: 125 LNLSCPNVEGGGML-FG--IDKEMV----KEITKKVVKEIGKPVWVKLTPQ--AKDIVEI 175 Query: 231 ADSLVRHNIDGVIATNTTLDRSLVQGMKN---CDQTGGLSG---RPLQLKSTEIIRRLSL 284 ++ + V+ NT L ++ + G SG +PL L+ + +L Sbjct: 176 VKAVKDAGGEAVVLFNTFLGLAIDWKKRKPVFKRIFAGYSGPAVKPLVLRYVWEVYEENL 235 Query: 285 ELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFI---FKGPPLIKEIVTHI 336 LPI+G GGI S E I AGASLVQI S + G L+KE + Sbjct: 236 -----LPIVGCGGIVSFSDVLEYIFAGASLVQIGSANFRDPWIGERLVKEAFKYF 285 >UniRef50_D2RBF2 Dihydroorotate dehydrogenase 1B n=21 Tax=Bifidobacteriaceae RepID=D2RBF2_GARVA Length = 333 Score = 59.3 bits (142), Expect = 2e-07, Method: Compositional matrix adjust. Identities = 57/205 (27%), Positives = 92/205 (44%), Gaps = 21/205 (10%) Query: 46 PVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVD 105 P G+ +KN +G A+G + C G+I V+P P GN PR Sbjct: 36 PTQVAGVKWKNMVGTASGTFQLAACRRFYDVSQLGAICTKGVSPVPWEGNPSPRTAE--S 93 Query: 106 AEGLINRMGFNNLGVDN-LVENVKKAHYDGVLGI-NIGKNKDTPVEQGKDDYLICMEKIY 163 G++N +G N GVD+ LV+ + K G L I N+ + D DDY +EK+ Sbjct: 94 PSGMVNAVGLQNPGVDHYLVDELPKLKKMGALVITNVAGHSD-------DDYAQVVEKLA 146 Query: 164 -AYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDL 222 + A + IN+S PN G ++ A+ L+AM K P+ VK+ P++ Sbjct: 147 DSAADMLEINVSCPN-----VTHGGMSVGTDPVALHRLIKRLRAMTDK--PMIVKMTPNV 199 Query: 223 SEEELIQVADSLVRHNIDGVIATNT 247 + +++ + + V D + NT Sbjct: 200 T--DIVSICKAAVDAGADALSMINT 222 >UniRef50_Q3B2I1 Dihydroorotate oxidase B, catalytic subunit n=12 Tax=Chlorobiaceae RepID=Q3B2I1_PELLD Length = 331 Score = 58.5 bits (140), Expect = 3e-07, Method: Compositional matrix adjust. Identities = 77/279 (27%), Positives = 129/279 (46%), Gaps = 36/279 (12%) Query: 51 GLTFKNPLGLAAGLDKDGECIDALGAMG-FGSIEIGTVTPRPQPGNDKPRLFRLVDAEGL 109 GL+ K+P+ LA+G GE + L + G I ++ + GN R+ G+ Sbjct: 37 GLSLKSPVMLASGTVSYGEELCRLTDLSKIGGIVTKAISLEARAGNPPQRIAE--TPSGM 94 Query: 110 INRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGY- 168 IN +G N+G+D + +K + LG I N + D+Y + ++ A G Sbjct: 95 INAIGLANVGIDRFIS--EKVPFLQTLGTAIVVNI---AGRSIDEYAEVVSRLDAVPGLD 149 Query: 169 -IAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEEL 227 IN+S PN G + G + D A + +L+++ ++ + +K+ P+++ Sbjct: 150 GYEINLSCPNVKG-ECMIMGVSPD----ATREIVTELRSITGRH--LMIKLTPNVTSISA 202 Query: 228 IQVADSLVRHNIDGVIATNTTLDRSLVQG-----MKNCDQTGGLSG---RPLQL-KSTEI 278 I +A + D V NT + ++ +KN TGGLSG +P+ L K E+ Sbjct: 203 IAIAAE--KAGADSVSLINTLVGMAIDWKKRRPLLKNV--TGGLSGPAIKPVALAKVWEV 258 Query: 279 IRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQI 317 +S+ PI+G+GGI S A E + AGA VQI Sbjct: 259 NNAVSI------PIVGMGGIASFDDAMEFLVAGAGAVQI 291 >UniRef50_Q979G6 Dihydroorotate dehydrogenase n=4 Tax=Thermoplasmatales RepID=PYRD_THEVO Length = 301 Score = 57.8 bits (138), Expect = 5e-07, Method: Compositional matrix adjust. Identities = 74/295 (25%), Positives = 130/295 (44%), Gaps = 42/295 (14%) Query: 51 GLTFKNPLGLAAG-LDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGL 109 G+ NP +A+G LD++G + L G ++ ++ + G P + D+ L Sbjct: 10 GIKLVNPFMVASGILDENGYTMKELLERGAAAVVTKSIGISERDGYPTPVIVEYGDS--L 67 Query: 110 INRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPV-----EQGKDDYLICMEKIYA 164 IN +G +N G++N E INI K P+ +++ K+ Sbjct: 68 INAVGLSNPGIENFGEE-----------INIAKEAKRPIIGSVFAYNAEEFTKLSVKMEE 116 Query: 165 YA-GYIAINISSPNTPGLRTLQYG---EALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAP 220 Y I +N+S P+ G L+ G + ++D++ IK+K VP+ K++P Sbjct: 117 YGVDAIELNLSCPHVKGF-GLEVGSDPDLVEDIVNEIKSKVK---------VPVFAKLSP 166 Query: 221 DLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKN---CDQTGGLSGRPLQLKSTE 277 ++S +I++A + D + NT ++ ++ + GGLSG ++ Sbjct: 167 NVSN--IIEIAKA--AEKADAYVLINTVKAMAIDIYSRSPVLSNLYGGLSGPAIKPVGIR 222 Query: 278 IIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 + + E IIGVGGI + A E I AGAS VQI + G + +E+ Sbjct: 223 YVYEVKKETGKE--IIGVGGISNYKDAIEYIMAGASAVQIGTALYKYGKGIFREM 275 >UniRef50_C0QYH6 Dihydroorotate dehydrogenase n=2 Tax=Brachyspira RepID=PYRD_BRAHW Length = 303 Score = 57.4 bits (137), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 78/301 (25%), Positives = 142/301 (47%), Gaps = 35/301 (11%) Query: 47 VNCMGLTFKNPLGLAAGLDKDGE-CIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVD 105 +N +G KN + ++G GE + G++ + +T + GN R+ Sbjct: 6 INFLGKELKNNVITSSGCFGFGEEYSNYFDVNELGAVNLKGITLNKKDGNKGTRIAE--T 63 Query: 106 AEGLINRMGFNNLGV----DNLVENVKKAHYDGVLGINI-GKNKDTPVEQGKDDYLICME 160 G+IN +G N G+ DN+++N+K Y + +NI G D V+ + I E Sbjct: 64 PSGMINCIGLENPGIEYFKDNIIKNIK---YSTPIILNINGATIDEYVKVAEIANEI--E 118 Query: 161 KIYAYAGYIAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKI 218 ++ ++ +NIS PN G+ E+ + A+K + + K P+ VK+ Sbjct: 119 RV----DFVELNISCPNVKNGGMAFGASCESAESTTKAVK------KVLSKK--PLIVKL 166 Query: 219 APDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKN---CDQTGGLSGRPLQLKS 275 +P++++ + +A ++ D V NT L + + + GGLSG ++ + Sbjct: 167 SPNVTD--IASIAKAVEDAGADSVSLVNTFLSMKIDTKTRKPLLGNIFGGLSGACIRPIA 224 Query: 276 TEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTH 335 ++ ++ + ++PI+G+GGI + A E I AGASLV I +G IF P L E++ Sbjct: 225 VRMVYQVYKAV--KIPIVGMGGITNYNDALEFILAGASLVSIGAG-IFSNPILPIEVING 281 Query: 336 I 336 I Sbjct: 282 I 282 >UniRef50_A4IM35 Dihydroorotate dehydrogenase n=348 Tax=Bacteria RepID=PYRD_GEOTN Length = 313 Score = 57.4 bits (137), Expect = 8e-07, Method: Compositional matrix adjust. Identities = 77/295 (26%), Positives = 133/295 (45%), Gaps = 35/295 (11%) Query: 51 GLTFKNPLGLAAGLDKDG-ECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGL 109 GL+ KNP+ A+G G E G+I I T P+ GN PR+ G+ Sbjct: 10 GLSLKNPIMPASGCFGFGREYAQFYDLSVLGAIMIKATTKEPRFGNSTPRVAE--TPSGM 67 Query: 110 INRMGFNNLGVDNLV--ENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAG 167 +N +G N G+D ++ E +D + NI + ++Y+ I Sbjct: 68 LNAIGLQNPGLDKVLAEELPWLEQFDVPIIANIAGST-------MEEYVEVAAAISKAPN 120 Query: 168 YIAI--NISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLS 223 A+ NIS PN G+ E +L +K VP+ VK++P+++ Sbjct: 121 VHALELNISCPNVKKGGIAFGTVPEVAAELTRLVKEVSA---------VPVYVKLSPNVT 171 Query: 224 EEELIQVADSLVRHNIDGVIATNTTLDRSL-VQGMKN--CDQTGGLSGRPLQLKSTEIIR 280 + ++ +A ++ + DG+ NT + + V+ + + TGGLSG ++ + +I Sbjct: 172 D--IVAMAKAIEQAGADGLTMINTLVGMRIDVKTGRPILANGTGGLSGPAVKPIAVRMIY 229 Query: 281 RLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQI-YSGFI--FKGPPLIKEI 332 +S ++ +PIIG+GG+ + E AGAS V + + FI F P +I E+ Sbjct: 230 EVSQAVS--IPIIGMGGVQTAEDVLEFFYAGASAVAVGTANFIDPFVCPTIINEL 282 >UniRef50_A3DM44 Dihydroorotate oxidase B, catalytic subunit n=1 Tax=Staphylothermus marinus F1 RepID=A3DM44_STAMF Length = 301 Score = 56.6 bits (135), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 78/294 (26%), Positives = 128/294 (43%), Gaps = 31/294 (10%) Query: 51 GLTFKNPLGLAAG-LDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGL 109 G+ FK+P+ A+G L + L G I T+T +P+ G P L GL Sbjct: 9 GIVFKHPIMNASGILASSINGVGILAKTGVAGIVTKTLTLKPREGYLPPITIPL--DYGL 66 Query: 110 INRMGFNNLGVDNLVENVKKAHYDGVLGI-NIGKNKDTPVEQGKD--DYLICMEK-IYAY 165 +N +G N G+D + V++ H G+ I +IG G+D ++ I EK + A Sbjct: 67 LNAVGLANPGIDAVNVLVEEIHKYGLPAIVSIG---------GRDPREFQILAEKALDAR 117 Query: 166 AGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEE 225 + +N+S P+TPG +D + T K L +P+ K+ Sbjct: 118 PEALELNLSCPHTPGF-------GVDTVATDEVLKHVALNVSSVSNIPVWGKLG---FSR 167 Query: 226 ELIQVADSLVRHNIDGVIATNT---TLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRL 282 +I+ ++ L+ + +D V+ NT V GGLSG + + + ++ Sbjct: 168 RIIRESEILLNNGVDAVVLINTLPGMFIDVYVGKPVLTHGFGGLSGPAIHPVAVYSVYKV 227 Query: 283 SLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 EL IIGVGG+ + E + AGA +QI +GF G ++ I+ I Sbjct: 228 YEELGAE--IIGVGGVIDWKTSVELLLAGAKAIQIGTGFYMVGYNIVNNILDGI 279 >UniRef50_Q01YA2 Dihydroorotate dehydrogenase n=5 Tax=Bacteria RepID=PYRD_SOLUE Length = 304 Score = 56.6 bits (135), Expect = 1e-06, Method: Compositional matrix adjust. Identities = 72/291 (24%), Positives = 125/291 (42%), Gaps = 44/291 (15%) Query: 43 PAKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAM-GFGSIEIGTVTPRPQPGNDKPRLF 101 P G+ KNP+ A+G G + L + G + ++ P GN PR+F Sbjct: 3 PQLATTICGIALKNPVLAASGTFAYGVEFEKLVDLNALGGFVVKGLSREPIEGNPPPRVF 62 Query: 102 RLVDAEGLINRMGFNNLGVDNLVEN-------VKKAHYDGVLGINIGKNKDTPVEQGKDD 154 G+IN +G N+GV V ++ A + V G +D Sbjct: 63 E--SEAGMINSVGLQNIGVRAFVAEKLPALAGLRTAVFANVFGYC------------TED 108 Query: 155 YLICMEKIYAYAGYIA--INISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHK 210 Y+ + + +AG +N+S PNT G+ L +++TA K Sbjct: 109 YVEVVRVLNDHAGLAGYELNVSCPNTAHGGIYFSNDPVLLAEVVTAAKRVATR------- 161 Query: 211 YVPIAVKIAPDLSE-EELIQVADSLVRHNIDGVIATNTTLDRSL---VQGMKNCDQTGGL 266 P+ VK++P++S E L +VA+ D + NT + ++ + + GGL Sbjct: 162 --PLIVKLSPNVSAIEPLARVAE---ESGADALSLVNTVISLAIDARTRRPRIGAGFGGL 216 Query: 267 SGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQI 317 SG ++ + + + + + R+P+IG+GGI + A E + AGAS V++ Sbjct: 217 SGPAIKPIALRFVYQAARAV--RIPVIGLGGIATGEDAAEFLIAGASAVEV 265 >UniRef50_A9BIU8 Dihydroorotate dehydrogenase family protein n=10 Tax=Bacteria RepID=A9BIU8_PETMO Length = 363 Score = 56.2 bits (134), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 77/304 (25%), Positives = 134/304 (44%), Gaps = 51/304 (16%) Query: 47 VNCMGLTFKNPLGLAAGLD-KDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVD 105 V+ +G+ K P+ AAG KDGE G G+I TV+ R KP + ++ Sbjct: 6 VDLLGMLLKTPVMPAAGPPIKDGESAHKAKEGGAGAIVTKTVSARAAK-VPKPNMAQV-- 62 Query: 106 AEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAY 165 G IN ++ L ++ +E + L + IG V +D + K+ + Sbjct: 63 KGGFINTELWSELSLEQWIEKEYPQVVETGLPVIIG------VGYTSEDIKEVIPKVERF 116 Query: 166 AGYIAIN---ISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDL 222 A ++ + + TP + +++ + DL P+ VK++P + Sbjct: 117 ADAFELSTHYLGNDPTPMINSIRAAKETTDL-------------------PVMVKLSPQV 157 Query: 223 SEEELIQVADSLVRHNIDGVIATNT---TLDRSLVQG---MKNCDQTGGLSGR---PLQL 273 ++ + A DG++ N+ TLD L G + + + G LSG+ PL L Sbjct: 158 ---DIPKFAKEAENAGADGLVLINSFGPTLDIDLESGKPLLGSENGFGWLSGQAIFPLAL 214 Query: 274 KST-EIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 +S E +R +++ P++GVGGI++ A + I AGA VQ+ + I GP + K+I Sbjct: 215 RSVFEAVRSVNI------PVVGVGGINTGKEAIKMIMAGAQAVQVCTAAILNGPQIYKKI 268 Query: 333 VTHI 336 I Sbjct: 269 TNEI 272 >UniRef50_B1GYY3 Dihydroorotate dehydrogenase n=1 Tax=uncultured Termite group 1 bacterium phylotype Rs-D17 RepID=PYRD_UNCTG Length = 306 Score = 55.8 bits (133), Expect = 2e-06, Method: Compositional matrix adjust. Identities = 75/285 (26%), Positives = 129/285 (45%), Gaps = 40/285 (14%) Query: 42 VPAKPVNCMGLTFKNPLGLAAGLDKDG-ECIDALGAMGFGSIEIGTVTPRPQPGNDKPRL 100 +P VN G+ KNP+ A+G G E D + G + TVT P+ GN +PR+ Sbjct: 2 IPDLSVNFAGIKLKNPVLTASGTFGYGYELADLIPLKRLGGVVTKTVTLEPRAGNLQPRI 61 Query: 101 FRLVDAEGLINRMGFNNLGVDNLVEN-VKKAHYDGV------LGINIGKNKDTPVEQGKD 153 + A G++N +G N+GV +E ++K + GV G+ +G Sbjct: 62 AEV--ASGILNSIGLQNIGVRAFIEEPLEKLNKIGVPVIVSVAGVAVG------------ 107 Query: 154 DYLICMEKIYAYAGYIAI--NISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKY 211 +Y+ ++ + + G AI N+S PN + D++ +K Sbjct: 108 EYVEIVKILSSQNGVSAIELNLSCPNLKKKIVCHDLPLMRDVIRGVKKVSR--------- 158 Query: 212 VPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSL-VQGMKNCDQT--GGLSG 268 VP+ K++P +++ + ++A + DGV TNT ++ ++ K T GG+SG Sbjct: 159 VPVIAKLSPLVTD--ISELALTAQNAGADGVTLTNTYPAMAVDIRTFKPKLSTVKGGMSG 216 Query: 269 RPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGAS 313 ++ S + ++ ++PIIG GGI A E I AGA+ Sbjct: 217 ACIKPMSVRCVYDAYQDI--KIPIIGCGGIMMGEDAVEFILAGAT 259 >UniRef50_C8WHP0 Dihydroorotate dehydrogenase family protein n=3 Tax=Bacteria RepID=C8WHP0_EGGLE Length = 356 Score = 54.3 bits (129), Expect = 6e-06, Method: Compositional matrix adjust. Identities = 80/332 (24%), Positives = 139/332 (41%), Gaps = 40/332 (12%) Query: 17 RAHEFTFQQLRRITGTPF-EALVRQKVPAK---PVNCMGLTFKNPLGLAAGLDKDG-ECI 71 RA + Q GT E R+ VP VN GL KNP+ +A+G G E Sbjct: 26 RARSNSPQDCSIRCGTRLVEGCPRRPVPTSVDMRVNLGGLEMKNPVTVASGTFAAGREYG 85 Query: 72 DALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVEN--VKK 129 D + G G++ V+ GN PR+ G++N +G N GV +L E Sbjct: 86 DFVDVAGLGAVTTKGVSLNGWAGNASPRIAET--PSGMLNSIGLQNPGVAHLKECDLPWL 143 Query: 130 AHYDGVLGINIGKNKDTPVEQGKDDYLICMEK-----IYAYAGYIAINISSPNTPGLRTL 184 A + +N+ + D+Y+ +E + AY +NIS PN + Sbjct: 144 AERGATVIVNVSGHS-------FDEYVQVIEALEDVPVDAYE----VNISCPNVDA-GGM 191 Query: 185 QYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIA 244 G D + + + + P+ VK+ P++++ + ++A + V D + Sbjct: 192 TIGTCTDSVEAVVSRCRAATKR------PLIVKLTPNVTD--VTEIARAAVSAGADALSL 243 Query: 245 TNTTLDRSLVQGMKN---CDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSV 301 NT L ++ + GGLSG ++ + ++ + ++ +P++G+GGI Sbjct: 244 INTLLGMAIDAERRRPQLARGVGGLSGPAVKPVALRMVWEVHQAVD--VPLLGMGGISCA 301 Query: 302 IAAREKIAAGASLVQIYSGFIFKGPPLIKEIV 333 A E + AGA+ V + + F P EI+ Sbjct: 302 TDAVEFMLAGATAVAVGTAN-FVNPHATVEII 332 >UniRef50_C5R8W8 Dihydroorotate dehydrogenase B, catalytic subunit n=1 Tax=Weissella paramesenteroides ATCC 33313 RepID=C5R8W8_WEIPA Length = 323 Score = 53.9 bits (128), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 77/281 (27%), Positives = 129/281 (45%), Gaps = 30/281 (10%) Query: 47 VNCMGLTFKNPLGLAAGLDKDG-ECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVD 105 V+ GL KNP ++G G + +D G++ + T T P+ GN +P + Sbjct: 8 VSLPGLKLKNPFMPSSGAFYYGLDHMDDFDLNKLGALVLKTTTLAPRTGNPQPWIVN--T 65 Query: 106 AEGLINRMGFNNLGV-----DNLVE-NVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICM 159 G++N +G N G+ D L E K +L I+ G D V+ K + Sbjct: 66 KAGILNSVGLANPGIAAVKADFLPELAAKLPDLPKMLSIS-GATVDEFVQLAK-----II 119 Query: 160 EKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIA 219 +K+ A I +N+S PN + G A + I + + ++A+ K I K++ Sbjct: 120 DKLPAI-NAIELNLSCPNVD-----EGGCAFGVTESGIHSVVSAVRAVTTKA--IYAKLS 171 Query: 220 PDLSEEELIQVADSLVRHNIDGVIATNTTLDRSL---VQGMKNCDQTGGLSGRPLQLKST 276 P++++ + + V DG+ NT + SL + + GGLSG L + Sbjct: 172 PNVTDIKPLAVTAE--NAGADGLTMVNTLVGMSLDLQSRSARLYRGKGGLSGEALHPLAV 229 Query: 277 EIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQI 317 E+I + ++ +PIIGVGG+ S+ A E + AGAS VQ+ Sbjct: 230 ELIWEAASAVH--IPIIGVGGVSSIDDALELMMAGASAVQV 268 >UniRef50_C9KKE5 Dihydroorotate oxidase n=6 Tax=Bacteria RepID=C9KKE5_9FIRM Length = 316 Score = 53.9 bits (128), Expect = 8e-06, Method: Compositional matrix adjust. Identities = 69/277 (24%), Positives = 131/277 (47%), Gaps = 27/277 (9%) Query: 48 NCMGLTFKNPLGLAAGLDKDGE-CIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDA 106 N +G+ + P+ A+G GE D + G + + T P+ GND R+ Sbjct: 9 NLLGIAMQTPVLTASGTFGFGEEFADFVDLSRLGGVMVKGTTLLPRRGNDGVRITE--TP 66 Query: 107 EGLINRMGFNNLGVDNLV-ENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAY 165 +G++N +G N GV++ + E + + G + + + + T + GK L+ + + A Sbjct: 67 KGMLNCIGLENPGVEHFLKETLPRIQQYG-MNVIVNISGSTAEDYGKLAGLLDVPGVAA- 124 Query: 166 AGYIAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLS 223 I +N+S PN G+ EA ++ A K H P+ +K++P+++ Sbjct: 125 ---IELNVSCPNVKEGGIVFGTDPEAASAVVRAAK---------AHTKKPVILKLSPNVT 172 Query: 224 EEELIQVADSLVRHNIDGVIATNTTLDRSL-VQGMKNC--DQTGGLSGRPLQLKSTEIIR 280 + ++ +A ++ D V NT L + + + + TGGLSG ++ + ++ Sbjct: 173 D--IVAMAKAVEAAGADAVSLINTLLGMEIDIHRFRPVLGNITGGLSGPCVKPVAVRMVW 230 Query: 281 RLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQI 317 +++ ++ +PIIG+GGI S A E AGAS V + Sbjct: 231 QVAQAVH--IPIIGMGGIASAEDAVEFFLAGASAVAV 265 >UniRef50_B8D3W9 Dihydroorotate dehydrogenase, PyrD n=1 Tax=Desulfurococcus kamchatkensis 1221n RepID=B8D3W9_DESK1 Length = 302 Score = 53.5 bits (127), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 73/283 (25%), Positives = 128/283 (45%), Gaps = 28/283 (9%) Query: 48 NCMGLTFKNPLGLAAG-LDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDA 106 + GL K+P+ A+G L + E ++ L GF ++ T+T P+ G P + L + Sbjct: 8 SIAGLRLKHPVMNASGILGSEPEHLEILAKQGFSALVSKTITLNPREGYPPPIIVELRN- 66 Query: 107 EGLINRMGFNNLGVDNLVENVKKA-HYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAY 165 GL+N +G N G + +KA L ++IG + VE+ + + ++ + Sbjct: 67 NGLLNAVGLANPGARVIPVLARKARELSKPLILSIGGSS---VEE-----FVKLAELASE 118 Query: 166 AGY--IAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLS 223 AG + +N+S P+ G YG L + D A+ +P+ K+ Sbjct: 119 AGVDAVELNLSCPHAEG-----YGLELGSDPMLVYRIVKD--AVSVASLPVIAKLG---L 168 Query: 224 EEELIQVADSLVRHNIDGVIATNTTLDRSL-VQGMKNC--DQTGGLSGRPLQLKSTEIIR 280 + +I+ A + + + NT S+ V +K ++ GGLSG P+ + ++ Sbjct: 169 TDRVIESAGKALEAGVKALTLINTVKAMSIDVYTLKPVLSNKYGGLSGPPIHPIAVRVVY 228 Query: 281 RLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIF 323 + E R IIGVGG+ S + E I AGA VQ+ + I+ Sbjct: 229 DVYREY--RAEIIGVGGVSSWMDVAELILAGARAVQVGTALIW 269 >UniRef50_C9M6H2 Dihydroorotate oxidase n=2 Tax=Synergistaceae RepID=C9M6H2_9BACT Length = 317 Score = 53.1 bits (126), Expect = 1e-05, Method: Compositional matrix adjust. Identities = 71/284 (25%), Positives = 126/284 (44%), Gaps = 45/284 (15%) Query: 51 GLTFKNPLGLAAGL---DKD---GECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLV 104 GL +PL +A+G+ +K+ GE +D GA+ +I T P+PGN R++ Sbjct: 13 GLDLTSPLVIASGIWPYEKEYWAGEYLDFAGAVCSKAI-----TADPRPGNPGTRVWE-- 65 Query: 105 DAEGLINRMGFNNLGVDNLVENV--KKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKI 162 G++N +G N G + + Y L +N+ + +E+ L ME + Sbjct: 66 TPCGMLNSIGLQNEGAGSFFGGTLGRLRSYGKPLLLNVSMESSSDLER----ILDAMEPV 121 Query: 163 YAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYV-PIAVKIAPD 221 + +N+S PN + +G +D LTA +Q + ++ P+ VK+ P Sbjct: 122 APSVDCVELNVSCPNV-DQGCMSWG--VDPALTA-----QAVQQVRRRWSGPLWVKLTPQ 173 Query: 222 LSEEELIQVADSLVRHNIDGVIATNTTLDRSL--VQGMKNCDQT-GGLSGR---PLQLKS 275 + VA + ++ NT L ++ V+ D+ GLSG PL L Sbjct: 174 APDP--CAVAKAAQDAGASALVVANTWLGAAIDTVKARPAFDRVVAGLSGPAIFPLAL-- 229 Query: 276 TEIIRRLSLELNGR--LPIIGVGGIDSVIAAREKIAAGASLVQI 317 R+ ++ G +P++G GG+ S +A + AGA+ V++ Sbjct: 230 -----RMVWQVCGAVDIPVVGCGGVASADSAVAMLMAGAAAVEV 268 >UniRef50_A1RZC9 Dihydroorotate oxidase B, catalytic subunit n=2 Tax=Archaea RepID=A1RZC9_THEPD Length = 299 Score = 52.8 bits (125), Expect = 2e-05, Method: Compositional matrix adjust. Identities = 83/304 (27%), Positives = 134/304 (44%), Gaps = 45/304 (14%) Query: 47 VNCMGLTFKNP-------LGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPR 99 V GL +NP LG++ GL K E DA G G++ TVT P+ G P Sbjct: 6 VEVAGLRLRNPVVVASGVLGVSVGLMKRAE--DA----GAGAVTSKTVTLNPREGYPNPV 59 Query: 100 LFRLVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINI--GKNKDTPVEQGKDDYLI 157 ++ L GL+N MG N G + + +++A VLGI + TP D+ L Sbjct: 60 VYEL--DYGLVNSMGLPNPGAEEMGRILREARR--VLGIPVIASIGASTP-----DEALR 110 Query: 158 CMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVK 217 E + + + +N S P+ GL DL++ + A+ + +K Sbjct: 111 IAEALEGFDA-LELNASCPHVKGLGA--------DLMSDPDAVYGIVSALKSSGYRVFLK 161 Query: 218 IAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLV-----QGMKNCDQTGGLSGRPLQ 272 ++P + + VA +DG A NT +++V + GGLSGR + Sbjct: 162 LSP---HGDYLAVARKAYSAGVDGFTAINTA--KAMVIDVYARKPVLGGVVGGLSGRAIH 216 Query: 273 LKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 + ++ L E +P+IG GG++ + A E I AGAS V + + + +G +I EI Sbjct: 217 PIAVRVVYELHREFP-EVPVIGTGGVEGWVEAVELILAGASAVGVGTA-LKRGFEVIGEI 274 Query: 333 VTHI 336 + I Sbjct: 275 LGGI 278 >UniRef50_A6G037 Dihydroorotate dehydrogenase 1 n=1 Tax=Plesiocystis pacifica SIR-1 RepID=A6G037_9DELT Length = 334 Score = 52.0 bits (123), Expect = 3e-05, Method: Compositional matrix adjust. Identities = 63/244 (25%), Positives = 108/244 (44%), Gaps = 22/244 (9%) Query: 80 GSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGIN 139 G + ++P P+ GN PR++ A G+IN +G N+G + + +K + L ++ Sbjct: 54 GGLSTKGISPLPRHGNPLPRIYE--TASGMINSIGLENVGCEAFL--TEKLPFLADLDVS 109 Query: 140 IGKNK-DTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTP--GLRTLQYGEALDDLLTA 196 + N T E D E + +NIS PN G+ E L A Sbjct: 110 VWVNFFGTDFETYVDCAKTLSEGGEGRIDVLEMNISCPNIKKGGIEFGTVPEVAHRLTKA 169 Query: 197 IKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSL-VQ 255 + VPI VK+ P++S+ ++ +A ++ GV NT ++ V+ Sbjct: 170 ---------CVEASEVPIVVKLTPNVSD--IVAMAQAVKEAGAIGVSLINTITAMAIDVR 218 Query: 256 GMKNCDQT--GGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGAS 313 ++ T GGLSG ++ + ++ +++ L G PI G+GGI + E AGA Sbjct: 219 SRRSRIATTYGGLSGPAIKPVALRMVHQVAKALPG-FPICGMGGILTGEDVLEYFIAGAH 277 Query: 314 LVQI 317 VQ+ Sbjct: 278 CVQL 281 >UniRef50_C5CHS6 Dihydroorotate dehydrogenase family protein n=1 Tax=Kosmotoga olearia TBF 19.5.1 RepID=C5CHS6_KOSOT Length = 361 Score = 51.6 bits (122), Expect = 4e-05, Method: Compositional matrix adjust. Identities = 41/134 (30%), Positives = 69/134 (51%), Gaps = 10/134 (7%) Query: 209 HKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNT-----TLDRSLVQG-MKNCDQ 262 H P+ +K P + E E++ A ++ DG++A N+ L R L + + Sbjct: 144 HTDKPVFLKFDPSVPEPEVM--AKAVEEAGGDGIVAINSLGPGYPLYRELKSSPLGSTHG 201 Query: 263 TGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFI 322 G +SG ++ + +++R++ N LPIIGVGGI S + I AGAS VQ+ SG + Sbjct: 202 FGWISGPVIKPIALAMVKRVASSCN--LPIIGVGGISSADDVIDFIMAGASAVQLLSGAL 259 Query: 323 FKGPPLIKEIVTHI 336 G + K+I+ + Sbjct: 260 LYGKSIYKKIIADL 273 >UniRef50_P28272 Dihydroorotate dehydrogenase n=168 Tax=cellular organisms RepID=PYRD_YEAST Length = 314 Score = 51.2 bits (121), Expect = 5e-05, Method: Compositional matrix adjust. Identities = 73/283 (25%), Positives = 116/283 (40%), Gaps = 40/283 (14%) Query: 53 TFKNPLGLAAGLD-KDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLIN 111 T++NP A+G+ + +D L G+ + T + GN +PR + G IN Sbjct: 13 TYENPFMNASGVHCMTTQELDELANSKAGAFITKSATTLEREGNPEPRYISV--PLGSIN 70 Query: 112 RMGFNNLGVD---NLVENVKKAHYDG------VLGINIGKNKDTPVEQGKDDYLICMEKI 162 MG N G+D + V N +K + D V G++I D+ L + KI Sbjct: 71 SMGLPNEGIDYYLSYVLNRQKNYPDAPAIFFSVAGMSI------------DENLNLLRKI 118 Query: 163 Y--AYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAP 220 + G +N+S PN PG + Y D LT K + A K P+ VK+ P Sbjct: 119 QDSEFNGITELNLSCPNVPGKPQVAY----DFDLT--KETLEKVFAFFKK--PLGVKLPP 170 Query: 221 DLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNC------DQTGGLSGRPLQLK 274 +A L + V + N+ + + K + GG+ G ++ Sbjct: 171 YFDFAHFDIMAKILNEFPLAYVNSINSIGNGLFIDVEKESVVVKPKNGFGGIGGEYVKPT 230 Query: 275 STEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQI 317 + +R L + +IG GGI S A E + GAS++QI Sbjct: 231 ALANVRAFYTRLRPEIKVIGTGGIKSGKDAFEHLLCGASMLQI 273 >UniRef50_A9D5Y9 Dihydroorotate dehydrogenase n=1 Tax=Shewanella benthica KT99 RepID=A9D5Y9_9GAMM Length = 334 Score = 51.2 bits (121), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 68/266 (25%), Positives = 109/266 (40%), Gaps = 34/266 (12%) Query: 71 IDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKKA 130 ++ LGA +I + T P+ GN +PR L G I MG NLG +E + + Sbjct: 51 LNLLGASASAAIMTKSCTLEPRQGNAEPRYQAL--PLGSIQSMGLPNLGYQAYLEMLPR- 107 Query: 131 HYDGVLGINIGKNKDTPVEQGKDDYLIC----MEKIY--AYAGYIAINISSPNTPGLRTL 184 L I + P+ + + M K + + A I +N S PN G Sbjct: 108 -----LKQAISPQTNKPIVVSVSGFSLADNLTMVKAFQASCADLIEVNFSCPNIEG--KP 160 Query: 185 QYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIA 244 Q G + A++ Q PI +K+ P I +A+ + + + + Sbjct: 161 QVGYDFEQTERALE------QLCQLGSKPIGLKLPPYFDFSHFITMANIIKKFPVRFITC 214 Query: 245 TNTTLDRSLVQG------MKNCDQTGGLSG---RPLQLKSTEIIRRLSLELNGRLPIIGV 295 N+ + ++ +K GGL G +P+ L + +R S L + IIGV Sbjct: 215 INSVGNTLVIDPETESAIIKPKGGFGGLCGDYIKPIGLAN---VRAFSQLLPSSIDIIGV 271 Query: 296 GGIDSVIAAREKIAAGASLVQIYSGF 321 GGI + A E + AGAS VQ+ + F Sbjct: 272 GGIKTGTDAFEYLLAGASAVQVATCF 297 >UniRef50_B0PGY1 Putative uncharacterized protein n=1 Tax=Anaerotruncus colihominis DSM 17241 RepID=B0PGY1_9FIRM Length = 371 Score = 50.8 bits (120), Expect = 6e-05, Method: Compositional matrix adjust. Identities = 69/297 (23%), Positives = 127/297 (42%), Gaps = 30/297 (10%) Query: 47 VNCMGLTFKNPLGLAAG-LDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVD 105 V +G+T KNP+ +AAG D I G ++ T+T PRL++ Sbjct: 5 VQFLGMTLKNPVIVAAGPWSCDAAAIQKSIDAGAAAVVTETITLEAST-RVCPRLYQ--H 61 Query: 106 AEGLINRMGFNNLGVDNLVENVKKA-HYDGVLGINI-GKNKDTPVEQGKDDYLICMEKIY 163 L N M ++ + ++ + +K+ D +L ++ G + K +E++ Sbjct: 62 GGSLFNTMLYSTIDLEQWEQEIKRIDKRDSILICSVWGATESETAYIAKK-----VERLG 116 Query: 164 AYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLS 223 A A I ++IS+P G R+ ++G + + + ++ + +P+ VK++ D S Sbjct: 117 ADA--IELSISAP--IGTRSTRFGRSQEQIGGYVRAVVEAVD------LPVMVKLSYDAS 166 Query: 224 EE-ELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSG---RPLQLKSTEII 279 + + I + + + GM GG SG RP+ L +T + Sbjct: 167 ANVAFVHAVEQAGAQAISAIDSLKGLAGVDIEHGMPLMPTCGGYSGANLRPVALATTATL 226 Query: 280 RRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 +L+ R I G+GGI+S E + GA+ VQ+ S + G I IV+ + Sbjct: 227 AQLT-----RCEICGIGGIESYEHVLEYVMLGANAVQLASTVLLAGYERITRIVSDL 278 >UniRef50_A6L5H1 Dihydroorotate dehydrogenase n=7 Tax=Bacteroidales RepID=PYRD_BACV8 Length = 303 Score = 50.4 bits (119), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 71/283 (25%), Positives = 130/283 (45%), Gaps = 36/283 (12%) Query: 47 VNCMGLTFKNPLGLAAGLDKDG-ECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVD 105 VN L NP+ A+G G E D + G I + T + GN PR+ Sbjct: 6 VNIGDLKLCNPVMTASGTFGYGKEFEDFVDLEKIGGIIVKGTTLHHREGNPYPRMAE--T 63 Query: 106 AEGLINRMGFNNLGVDNLVENV----KKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEK 161 G++N +G N GVD VE++ + H + ++ ++ + VE DY+ E Sbjct: 64 PMGMLNAVGLQNKGVDYFVEHIYPQIRDIHTNMIVNVS-----GSAVE----DYVKTAEI 114 Query: 162 I--YAYAGYIAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVK 217 I + I +NIS PN G+ +++ A++N ++ K + VK Sbjct: 115 INDLDHIPAIELNISCPNVKQGGMAFGVSACGCSEVVKAVRN-------VYKK--TLIVK 165 Query: 218 IAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKN---CDQTGGLSGRPLQLK 274 ++P++++ + ++A + D V NT L ++ + TGG+SG ++ Sbjct: 166 LSPNVTD--ITEIARAAEASGADSVSLINTLLGMAVDAEKRRPVLSTITGGMSGAAVKPI 223 Query: 275 STEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQI 317 + ++ +++ +N +P+IG+GGI A E + AGA+ +QI Sbjct: 224 ALRMVWQVAKAVN--IPVIGLGGIMGWKDAVEFMLAGATAIQI 264 >UniRef50_A4VL83 Phosphoserine aminotransferase n=1 Tax=Pseudomonas stutzeri A1501 RepID=A4VL83_PSEU5 Length = 485 Score = 50.4 bits (119), Expect = 8e-05, Method: Compositional matrix adjust. Identities = 42/202 (20%), Positives = 85/202 (42%), Gaps = 11/202 (5%) Query: 132 YDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALD 191 ++G + I D Q + + + +A Y+ +N+ P + L L L Sbjct: 294 HNGAARLGISLTLD--ARQASAESRAMLRAAWPHADYLMLNLIGPTSAPL--LSQSTRLR 349 Query: 192 DLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDR 251 LL A+ ++Q L + VP+ K+ + E +A LV DG++A + Sbjct: 350 HLLAALVDEQRQLNQDGRRRVPLLAKLR-CMPERTPFSIAGLLVELGFDGLLAAHDPGPP 408 Query: 252 SLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAG 311 + + + Q + + I L + ++ VGG+ + R +++AG Sbjct: 409 ATAERYRAWQDPRR------QAHACQQIEDLRRFCGPDMALLSVGGVQTADHLRARMSAG 462 Query: 312 ASLVQIYSGFIFKGPPLIKEIV 333 A LVQ+++ F+ + P L + ++ Sbjct: 463 AELVQVHTAFMHQSPWLARRLL 484 >UniRef50_D0JBI0 Dihydroorotate dehydrogenase n=2 Tax=Blattabacterium RepID=D0JBI0_BLASB Length = 320 Score = 50.1 bits (118), Expect = 1e-04, Method: Compositional matrix adjust. Identities = 77/266 (28%), Positives = 113/266 (42%), Gaps = 45/266 (16%) Query: 80 GSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVD---NLVE--NVKKAHYDG 134 G+I + T +P+ GN KPR F G IN MG NLG+D N +E KK + Sbjct: 51 GAIVTKSCTRQPRKGNIKPRYFEW--NVGSINSMGLPNLGIDFYLNFLEEKKTKKPVFLS 108 Query: 135 VLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLL 194 + G++I ++ K ++ KI A I +N+S PN LQ E L L Sbjct: 109 ISGLSI---EEIFFLLKKANF---SSKITA----IELNLSCPN------LQ-EEILGYDL 151 Query: 195 TAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTL----- 249 I + ++ + K P+ +K+ P EE + ++ L + I V N+ Sbjct: 152 YKIYDFLENVFKFNEK--PLGIKLPPYFKEEYIKNMSLILNQFPIVFVTCINSLPNGIFV 209 Query: 250 ----DRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAR 305 + S++Q GG +P L + IR+ L + IIG GGI Sbjct: 210 DPRNETSVIQPRNGFGGIGGSIIKPFALAN---IRKFYTYLRKDISIIGCGGISYGKDIF 266 Query: 306 EKIAAGASLVQIYSGFIFKGPPLIKE 331 E I GAS VQI G L+KE Sbjct: 267 EHILCGASAVQI-------GTQLMKE 285 >UniRef50_Q1AVZ1 Dihydroorotate oxidase B, catalytic subunit n=1 Tax=Rubrobacter xylanophilus DSM 9941 RepID=Q1AVZ1_RUBXD Length = 304 Score = 49.3 bits (116), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 74/288 (25%), Positives = 125/288 (43%), Gaps = 36/288 (12%) Query: 43 PAKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFR 102 P V G+ PL A+G +A G +G++ TVT RP+ GN PR+ Sbjct: 4 PELSVELCGVRLATPLIPASGTLAPEALGEAAGV--YGAVLPKTVTLRPRQGNPPPRVAE 61 Query: 103 LVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKI 162 G++N +G N GV+ + + G + + E ++ L+C ++ Sbjct: 62 --SPAGMVNSIGLQNPGVEEFLRAL------GAWEVGVPVFVSVAGETVEEFALLC-GRV 112 Query: 163 YA--YAGYIAINISSPNTP-GLRTLQYG-EALDDLLTAIKNKQNDLQAMHHKYVPIAVKI 218 A A I +N+S PN G + G A+++++ A + D VP+ K Sbjct: 113 AADGRAAAIELNLSCPNVERGGQVFCAGPSAVEEVVAACRRAAPD--------VPLLAK- 163 Query: 219 APDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSG---RPLQLKS 275 L+ E ++Q A + DG+ NT ++ + GGLSG +PL L++ Sbjct: 164 ---LALEGVVQNALAAEAAGADGLTVMNTVPALAVDARARRVLLRGGLSGPAIKPLALRA 220 Query: 276 TEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYS-GFI 322 + + +P++G GG+ S E + AGA VQ+ S GF+ Sbjct: 221 VYDVASAA-----EIPVVGCGGVCSGADVAEFMLAGARAVQVGSAGFV 263 >UniRef50_B8D2W4 Dihydroorotate dehydrogenase family protein n=1 Tax=Desulfurococcus kamchatkensis 1221n RepID=B8D2W4_DESK1 Length = 407 Score = 49.3 bits (116), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 38/131 (29%), Positives = 66/131 (50%), Gaps = 10/131 (7%) Query: 212 VPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNT---TLDRSLVQGMKNCDQT---GG 265 +PI K++P + ++ L + +DG++ATNT L + G+ G Sbjct: 186 IPIFPKLSP--FTPNIPELVKELEKVGVDGIVATNTIGPALHIDVETGLPIVGGPYGYGW 243 Query: 266 LSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKG 325 +SG L+ + ++ +++L N +LP+IGVGGI + E AGAS VQI + + +G Sbjct: 244 MSGPALKPLALAVVSQVAL--NTKLPVIGVGGISRGVDVIEYFMAGASAVQICTAALIEG 301 Query: 326 PPLIKEIVTHI 336 P I+ + Sbjct: 302 PQAFARIIREV 312 >UniRef50_Q1MQG1 Dihydroorotate dehydrogenase n=2 Tax=Deltaproteobacteria RepID=Q1MQG1_LAWIP Length = 314 Score = 48.9 bits (115), Expect = 2e-04, Method: Compositional matrix adjust. Identities = 69/280 (24%), Positives = 123/280 (43%), Gaps = 39/280 (13%) Query: 52 LTFKNPLGLAAGLDKDGECIDALGAMG-FGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLI 110 L KNP+ A+G G G + G I + ++ +P+ GN PR+ G++ Sbjct: 20 LVLKNPVLTASGTFGYGAEFIGYGDLSQLGGIIVKGLSLKPRKGNPLPRIAE--TPCGML 77 Query: 111 NRMGFNNLGVDNLVEN-VKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYI 169 N +G N GV+ ++ + + + K+TPV + Y +E+ + Sbjct: 78 NTIGLQNDGVELFIQKKLPRLPW-----------KETPVIA--NLYATSVEEFSELTAIL 124 Query: 170 A---------INISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAP 220 A +N+S PN T +G+ D L A K + + P+ VK++P Sbjct: 125 AAEEGVAALEVNVSCPNVKSGGTF-FGQ--DPSLAA---KVTEAVCKNAGSKPVMVKLSP 178 Query: 221 DLSEEELIQVADSLVRHNIDGVIATNTTLDRSL-VQGMKNCDQT--GGLSGRPLQLKSTE 277 ++++ +I A ++ D + NT ++ ++ K+ T GGLSG ++ + Sbjct: 179 NVTDITII--AKAVESAGADAISCINTLTGMAVDIRKRKSLLSTVIGGLSGPGIKPIALR 236 Query: 278 IIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQI 317 + + +N +P+IG+GGI S E I GA VQI Sbjct: 237 CVWEVCKAVN--IPVIGIGGITSARDVLEFILVGAHAVQI 274 >UniRef50_B0TGQ8 Dihydroorotate dehydrogenase n=32 Tax=Bacteria RepID=PYRD_HELMI Length = 309 Score = 48.5 bits (114), Expect = 3e-04, Method: Compositional matrix adjust. Identities = 67/279 (24%), Positives = 123/279 (44%), Gaps = 28/279 (10%) Query: 47 VNCMGLTFKNPLGLAAGLDKDG-ECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVD 105 VN GLT KNP+ A+G G E + G+I + T P+ GN PR+ Sbjct: 8 VNLGGLTMKNPVTTASGTFGFGLEFAPFIDLSRLGAIVVKGTTLEPREGNPTPRMAE--T 65 Query: 106 AEGLINRMGFNNLGVDNLVENVKKA--HYDGVLGINIGKNKDTPVEQGKDDYLICMEKIY 163 G++N +G N GV+ + + D + +N+ N +DY + Sbjct: 66 PAGMLNAIGLQNPGVEAFIRDYLPPLRQIDTPVIVNVSGNS-------VEDYGRLASILD 118 Query: 164 AYAGYIA--INISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPD 221 G A +NIS PN +Q+G + + + Q P+ VK++P+ Sbjct: 119 EADGVAALEVNISCPNVKE-GGIQFGTLPASAAAVTRAVRENTQK------PVIVKLSPN 171 Query: 222 LSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKN---CDQTGGLSGRPLQLKSTEI 278 ++ ++ ++A ++V D + NT L + + + GGLSG ++ + + Sbjct: 172 VT--DITEMARAVVDAGADALALINTLLGMDIDICTRRPVLANIFGGLSGPAIKPVALRM 229 Query: 279 IRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQI 317 I ++ ++ +PI+G+GGI + A + AGA+ + + Sbjct: 230 IYQVYRAVH--VPILGMGGIMNSQDAIAFMLAGATAIAV 266 >UniRef50_C4F860 Putative uncharacterized protein n=2 Tax=Collinsella RepID=C4F860_9ACTN Length = 307 Score = 48.1 bits (113), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 65/276 (23%), Positives = 110/276 (39%), Gaps = 28/276 (10%) Query: 51 GLTFKNPLGLAAGLDKDGECIDALGAMG-FGSIEIGTVTPRPQPGNDKPRLFRLVDAEGL 109 G+ KNP+ A+G G L + G+I PGN PR+ + G+ Sbjct: 12 GVKMKNPINTASGTFGYGWQFSELMDVSQLGAITTKGCAAEAWPGNPAPRMAEVPG--GM 69 Query: 110 INRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICME---KIYAYA 166 +N +G N GV E D L + ++Y+ +E ++ +A Sbjct: 70 MNSVGLQNPGVAAFAEQSGPWLAD--LTAKGTQVICQVAGHSTEEYVRALEMFVELCPWA 127 Query: 167 GYIAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSE 224 IN+S PN G E +++ A + + P+ VK+AP Sbjct: 128 AGYEINVSCPNIAAGGAACGSTPEGASEVMRACRKVTDK---------PLFVKMAP---- 174 Query: 225 EELIQVADSLVRHNIDGVIATNTTLDRSL---VQGMKNCDQTGGLSGRPLQLKSTEIIRR 281 + ++A +L DG+ N+ S+ + + TGGLSG + ++ Sbjct: 175 VRIPEIARALEAEGADGLTVINSIPGMSIDVRTRRSRLSKPTGGLSGPLCHPIAVRMVWE 234 Query: 282 LSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQI 317 + ++ +PI GVGG+ + A E I AGA V + Sbjct: 235 AANAVD--IPICGVGGVMTGEDAAEFILAGACCVSV 268 >UniRef50_A4ECL7 Putative uncharacterized protein n=1 Tax=Collinsella aerofaciens ATCC 25986 RepID=A4ECL7_9ACTN Length = 302 Score = 47.8 bits (112), Expect = 5e-04, Method: Compositional matrix adjust. Identities = 68/286 (23%), Positives = 115/286 (40%), Gaps = 48/286 (16%) Query: 51 GLTFKNPLGLAAGLDKDG-ECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGL 109 G+ +NP+ AAG G + + G+I P PGN PR+ + G+ Sbjct: 7 GVKMQNPINTAAGTFGYGWQFQNFFDVSQLGAITTKGCAAEPWPGNPAPRMAEIPG--GM 64 Query: 110 INRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQ----GKDDYLICME---KI 162 IN +G N GV A G + K+ + Q D+++ +E ++ Sbjct: 65 INSVGLQNPGVAAF------ARESGPWLEQLSKDGCQVICQVAGHSVDEFVRALEMYVEL 118 Query: 163 YAYAGYIAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAP 220 +A IN+S PN G E ++ A + + P+ VK+AP Sbjct: 119 CPWAAGYEINVSCPNIAAGGAAMGSTPEGASSVMAACRKVTDK---------PLFVKMAP 169 Query: 221 DLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGM---------KNCDQTGGLSGRPL 271 + ++A +L DG+ N+ +QGM + GGLSG Sbjct: 170 ----VNVAEIAKALEAAGADGLSVINS------IQGMAIDVHTRKSRVAKPKGGLSGPLC 219 Query: 272 QLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQI 317 + ++ ++ ++ +PI GVGG+ + A E I AGA+ V + Sbjct: 220 HHIAVRMVWEVAQAVD--IPINGVGGVMTGEDAAEFILAGATCVSV 263 >UniRef50_O08358 Dihydroorotate dehydrogenase n=12 Tax=Sulfolobaceae RepID=PYRD_SULAC Length = 291 Score = 47.8 bits (112), Expect = 6e-04, Method: Compositional matrix adjust. Identities = 51/183 (27%), Positives = 90/183 (49%), Gaps = 18/183 (9%) Query: 153 DDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYV 212 ++Y+ + KI I +N+SSPN G +GE+ LT ++ +++++ K Sbjct: 99 NEYIDAVSKINDIPVMIELNVSSPNRRG-----FGESN---LTYVEEIVKNVKSIVKK-- 148 Query: 213 PIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSL-VQGMKNCDQ--TGGLSGR 269 P+ VK+ P + ++++A + DG+ NT + V+ K TGG+SG+ Sbjct: 149 PVFVKLGP---WDNIVEIAGRALSAGADGLTLINTLKGMLIDVEDFKPILSYGTGGISGK 205 Query: 270 PLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLI 329 + + +I + E IIGVGG+ A E I+ GA LV + + + KG +I Sbjct: 206 CIHALAVRVIHDVFKEYEPE--IIGVGGVFDWRDAIELISVGAKLVGLGTVLVEKGFDVI 263 Query: 330 KEI 332 +EI Sbjct: 264 REI 266 >UniRef50_Q9YFI6 Dihydroorotate dehydrogenase n=3 Tax=Desulfurococcales RepID=PYRD_AERPE Length = 306 Score = 47.0 bits (110), Expect = 9e-04, Method: Compositional matrix adjust. Identities = 73/309 (23%), Positives = 130/309 (42%), Gaps = 44/309 (14%) Query: 43 PAKPVNCMGLTFKNPLGLAAGL----DKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKP 98 P ++ GL + P+G A+G+ ++ ++ G G +VT +P+ G +P Sbjct: 5 PELSISIAGLRLQRPVGNASGILGWEPREARLVEEGGG---GFFVAKSVTYQPRKGYPQP 61 Query: 99 RLFRLVDAEGLINRMGFNNLGVDN----LVENVKKAHYDGVLGINIGKNKDTPVEQGKDD 154 L+ + A G++N +G N G L + V++A + I G + Sbjct: 62 HLYPV--AGGIVNAVGLANPGFREASKMLAQTVEEASIPVIASIAGGAPGE--------- 110 Query: 155 YLICMEKIYAYAGYIAI--NISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYV 212 + M AG A+ N+S P+ G L+ G+ + + + + L+ + Sbjct: 111 -WVEMASTLEEAGVSAVELNLSCPHFAG-GGLELGQDPAAVASVVSAVASTLR------I 162 Query: 213 PIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSL-VQGMKNC--DQTGGLSGR 269 P+ K+ + L+ A + G+ N+ + V K ++ GGLSG+ Sbjct: 163 PVIAKLG---YSDRLVDAASKALEAGARGLTLINSMRAMKIDVYAKKPVLGNRVGGLSGK 219 Query: 270 PLQLKSTEIIRRLSLELNG--RLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPP 327 P+ I R E+ G R I GG++S A E AGA VQ+ + FI GP Sbjct: 220 PIH----PIAVRAVYEVYGETRADIFAAGGVESWEDAVEFYLAGAKAVQVGAAFITIGPH 275 Query: 328 LIKEIVTHI 336 +++ IV + Sbjct: 276 VLRSIVEGV 284 >UniRef50_A0DS83 Chromosome undetermined scaffold_61, whole genome shotgun sequence n=1 Tax=Paramecium tetraurelia RepID=A0DS83_PARTE Length = 388 Score = 47.0 bits (110), Expect = 0.001, Method: Compositional matrix adjust. Identities = 19/39 (48%), Positives = 27/39 (69%) Query: 52 LTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPR 90 + KN LGLA+G D DG ++ L +GFG IEIG++T + Sbjct: 77 IKLKNQLGLASGFDNDGSFVETLQNLGFGFIEIGSITAQ 115 Score = 43.1 bits (100), Expect = 0.013, Method: Compositional matrix adjust. Identities = 20/61 (32%), Positives = 38/61 (62%) Query: 273 LKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 L+ + ++++ +L +I VGGI + + +E++ GA QI+S F+ KGP +IK+I Sbjct: 327 LEYNKTLKQVRQQLPKSCTLISVGGIKTKVQFQERLNNGADACQIFSSFVAKGPHVIKDI 386 Query: 333 V 333 + Sbjct: 387 L 387 >UniRef50_Q4DGY9 Dihydroorotate dehydrogenase, putative n=1 Tax=Trypanosoma cruzi RepID=Q4DGY9_TRYCR Length = 280 Score = 47.0 bits (110), Expect = 0.001, Method: Compositional matrix adjust. Identities = 56/208 (26%), Positives = 87/208 (41%), Gaps = 48/208 (23%) Query: 34 FEALVR----QKVPAKPVNCMGLTFKNPLGLAAGL----DKDGECIDALGAMGFGSIEIG 85 F LVR QK+ +N + F NP AAG+ ++D C+ A + G++ Sbjct: 34 FFPLVRVYATQKMMRLKLNLLDHVFANPFMNAAGVLCSTEEDLRCMTASSS---GALVSK 90 Query: 86 TVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVD-------NLVENVKKAHYDGVLGI 138 + T P+ GN +PR + G IN MG NLG D +L + KK + + G+ Sbjct: 91 SCTSAPRDGNPEPRY--MAVPLGSINSMGLPNLGFDFYLKYASDLHDYSKKPLFLSISGL 148 Query: 139 NIGKN-----KDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDL 193 ++ +N + PV Q K L +N+S PN PG + Y Sbjct: 149 SVEENVAMVRRLAPVAQEKGVLL-------------ELNLSCPNVPGKPQVAYD------ 189 Query: 194 LTAIKNKQNDLQAMHHKY-VPIAVKIAP 220 + + LQ + Y +P VK+ P Sbjct: 190 ---FEAMRTYLQQVSLAYGLPFGVKMPP 214 >UniRef50_D0U5Z4 Dihydroorotate dehydrogenase subfamily 1 family protein n=1 Tax=uncultured actinobacterium RepID=D0U5Z4_9ACTN Length = 324 Score = 46.6 bits (109), Expect = 0.001, Method: Compositional matrix adjust. Identities = 72/288 (25%), Positives = 123/288 (42%), Gaps = 48/288 (16%) Query: 52 LTFKNPLGLAAGLDKDGECIDALGAMG-FGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLI 110 + FK+P+ LA+G + ++ + G+I + +++ GN PRL R + G++ Sbjct: 16 VEFKSPVLLASGTAGHADELEPYFPLSKIGAIVVKSMSSFEWAGNKAPRL-RPTNG-GML 73 Query: 111 NRMGFNNLGVDNLVEN-------VKKAHYDGVLGINIGKNKDTPVEQGKDDYLIC---ME 160 N +G LGV + +E+ VK + G +I DDY + Sbjct: 74 NAVGLQGLGVAHWIEHDLPRLKKVKATIVASIWGFSI------------DDYRSAASLLS 121 Query: 161 KIYAYAGYIAINISSPN----TPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAV 216 ++ I IN+S PN + T A D+ L+A ++ VP+ Sbjct: 122 EVSTDLAAIEINLSCPNIGSSSKAANTPHGIFAHDEDLSA-----EIVRVCSVAKVPLWA 176 Query: 217 KIAPDLSEEELIQVADSLVRHNIDGVIATNTTL------DRSLVQGMKNCDQTGGLSGRP 270 K++P+ + ++ VA ++ + V NT L + L G P Sbjct: 177 KLSPN--TDRVVDVAAAVSKAGCQAVTLINTALGLAIDVETGLPALGNGGGGLSGSGIHP 234 Query: 271 LQLKSTEIIR-RLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQI 317 + +++ +R RL RLPIIGVGGI + A E + AGAS +Q+ Sbjct: 235 IAVRTIFDVRTRLP-----RLPIIGVGGIANGEDAIEMMMAGASCIQV 277 >UniRef50_C7M0V6 Dihydroorotate dehydrogenase family protein n=1 Tax=Acidimicrobium ferrooxidans DSM 10331 RepID=C7M0V6_ACIFD Length = 309 Score = 46.6 bits (109), Expect = 0.001, Method: Compositional matrix adjust. Identities = 70/271 (25%), Positives = 118/271 (43%), Gaps = 21/271 (7%) Query: 52 LTFKNPLGLAAGLDKDG-ECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLI 110 L NP+ AAG G E A+ G+ + ++T GN PRL + G++ Sbjct: 11 LVLANPILTAAGCGGYGTELAAAVALERLGAHVVKSLTTVATEGNPAPRLAPV--PGGMV 68 Query: 111 NRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIA 170 N +G G+D + + D + + + P + G + + +I YI Sbjct: 69 NSVGLAGPGIDRWLAETWPSLADARIPVALSVWGRQPRDYG--ETVRRAARIAPSLVYIE 126 Query: 171 INISSPNTPGLRTLQYGE--ALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELI 228 +N+S PN R L + A ++ A++++ PI VK++ + + ++ Sbjct: 127 LNLSCPNLEADRALFAHDPNATARVVGAVRDEVA---------TPILVKLSAN--TDRIV 175 Query: 229 QVADSLVRHNIDGVIATNTTLDRSLVQGMK--NCDQTGGLSGRPLQLKSTEIIRRLSLEL 286 VA + V DG++A NT + G + + GGLSGR +Q + + L L Sbjct: 176 DVAHAAVAAGADGLVAINTLFAQWYDDGREALGTARGGGLSGRAVQPIALRAVADLRAAL 235 Query: 287 NGRLPIIGVGGIDSVIAAREKIAAGASLVQI 317 +PIIGVGG+ + + AGA VQI Sbjct: 236 P-TVPIIGVGGVATADDVERFVRAGADAVQI 265 >UniRef50_A8MJK5 Dihydroorotate dehydrogenase family protein n=1 Tax=Alkaliphilus oremlandii OhILAs RepID=A8MJK5_ALKOO Length = 372 Score = 46.6 bits (109), Expect = 0.001, Method: Compositional matrix adjust. Identities = 67/287 (23%), Positives = 127/287 (44%), Gaps = 32/287 (11%) Query: 47 VNCMGLTFKNPLGLAAG-LDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVD 105 VN +GL+ KNP+ ++AG L G + G G++ T+ +P N +PRL + Sbjct: 5 VNFLGLSLKNPIIVSAGPLTGSGSMMRKAIEAGAGAVVTKTIANEIRP-NVRPRLVK--G 61 Query: 106 AEGLINRMGFNNLGVDNLVENVKKAHYDGVLGI-NIGKNKDTPVEQGKDDYLICMEKIYA 164 EGL N ++ ++ + A G + I NI + + + Y+ +K+ Sbjct: 62 REGLHNIELYSGFTLEEWENEIAYAKIHGAVVIANILGHTSSEIA-----YI--AQKVEQ 114 Query: 165 Y-AGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKY-VPIAVKIAPD- 221 + A + + +S P +GE L+ +++ +A+ + +P+ VK++ + Sbjct: 115 FGADAVELGVSCP---------HGEGLEGVISEPSKLYEFTKAVVDRIKIPVMVKLSSNT 165 Query: 222 LSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSG---RPLQLKSTEI 278 ++ +L + A+ I G+ + + +G GG SG RP+ L + Sbjct: 166 VNVVKLARAAEKAGASAISGIDTVRSIAGVDIEKGRVLLPTFGGYSGDAIRPIGLAAIAS 225 Query: 279 IRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKG 325 I + + +PI G+GGI + E + GAS VQ+ + I G Sbjct: 226 IAQAT-----SIPICGIGGITNYEHILEYMMLGASTVQVCTSIILNG 267 >UniRef50_A4FBL7 Dihydroorotate dehydrogenase n=1 Tax=Saccharopolyspora erythraea NRRL 2338 RepID=A4FBL7_SACEN Length = 338 Score = 46.2 bits (108), Expect = 0.002, Method: Compositional matrix adjust. Identities = 67/278 (24%), Positives = 113/278 (40%), Gaps = 58/278 (20%) Query: 79 FGSIEIGTVTPRPQPGNDKPR-----------------LFRLVDAEGLINRMGFNNLGVD 121 FG++ T+T P+ G+ R R VD G +N G+ N+G+D Sbjct: 63 FGAVTTRTLTVEPREGHFTTRDQWPLHELPALLKRYGQALRQVDG-GWLNAFGWCNVGLD 121 Query: 122 NLVENVKKAHYDGVLGINIGKNKDTPVEQG---KDDYLICMEKI--YAYAGYIA---INI 173 + + +Y G N T + G ++++ ++KI AG IA N+ Sbjct: 122 AYLRD----YYPRTRGQN------TIISVGGFSAEEFVTLIDKINDAVPAGDIAAVEFNV 171 Query: 174 SSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADS 233 S N + ++ +L +A+ P+ +K++PD + + A Sbjct: 172 SCHNV----NFDFNAIIESVLA---------EAVPRSAHPVILKLSPDY---DYLAHARL 215 Query: 234 LVRHNIDGVIATNTT----LDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGR 289 +H + + A NT LD Q + ++ GGLSGR ++ ++ L + + Sbjct: 216 AAKHGVSALTAINTVKGLRLDPETGQPLLK-NRFGGLSGRAIKPIGLRVVAELR-DAGVK 273 Query: 290 LPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPP 327 LPII GGI + RE AGA V + S F P Sbjct: 274 LPIIATGGIRTFDDCREYFWAGADAVSLGSATWFASYP 311 >UniRef50_A3CL85 NADH-dependent flavin oxidoreductase, putative n=1 Tax=Streptococcus sanguinis SK36 RepID=A3CL85_STRSV Length = 367 Score = 45.8 bits (107), Expect = 0.002, Method: Compositional matrix adjust. Identities = 46/211 (21%), Positives = 97/211 (45%), Gaps = 37/211 (17%) Query: 144 KDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNT----------PGLRTLQYGEALDDL 193 K+ VEQ +D+L + + AG+ + + NT P +R ++G +L++ Sbjct: 138 KNAEVEQVIEDFLSAIRRAIQ-AGFDGVELHGANTYLIQQFVSPHPNVRQDKWGGSLNNR 196 Query: 194 L----TAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSL------VRHNIDGVI 243 L T +K + ++ + I + +P+ EE IQ+ D+L + H +D + Sbjct: 197 LRFPKTLLKRAKQLVKEEADRPFLIGYRFSPEEIEEPGIQLYDTLQLLEQLIYHQVDYLH 256 Query: 244 ATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIA 303 + + + RS ++ ++ S +I+++ ++NGR+P+IGVG I + Sbjct: 257 ISTSDVWRSSIRDSQD---------------SEPVIQKIIKKINGRVPLIGVGQIKTKQD 301 Query: 304 AREKIAAGASLVQIYSGFIFKGPPLIKEIVT 334 A+ + AG L + + P +++V+ Sbjct: 302 AQRVLDAGIPLFALGKALLLD-PDWAEKVVS 331 >UniRef50_A9GKC4 Dihydropyrimidine dehydrogenase n=5 Tax=Bacteria RepID=A9GKC4_SORC5 Length = 462 Score = 45.8 bits (107), Expect = 0.002, Method: Compositional matrix adjust. Identities = 39/153 (25%), Positives = 77/153 (50%), Gaps = 16/153 (10%) Query: 195 TAIKNKQNDLQ-----AMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTT- 248 +A+ N+ LQ A+ P+ VK+ P++ + +++ ++++R GV NT Sbjct: 145 SAVGNEPAVLQEIARWAVEFATTPVIVKLTPNVGD--ILEPGEAVLRSGAHGVSLINTVK 202 Query: 249 ------LDRSL-VQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELN-GRLPIIGVGGIDS 300 L+R + + + GG G ++ + ++ +L+ GRLPI G+GGI + Sbjct: 203 SLMGVDLERMVPLPRVGGASTNGGYCGPAVKPIALHLLSQLARHPGVGRLPISGIGGISN 262 Query: 301 VIAAREKIAAGASLVQIYSGFIFKGPPLIKEIV 333 A E IA GA+ VQ+ + + G +++E++ Sbjct: 263 SRDAAEFIALGATSVQVCTAVMHYGYRIVEEMI 295 >UniRef50_A3U0T3 Probable dihydroorotate dehydrogenase, catalytic subunit n=1 Tax=Oceanicola batsensis HTCC2597 RepID=A3U0T3_9RHOB Length = 314 Score = 45.4 bits (106), Expect = 0.003, Method: Compositional matrix adjust. Identities = 73/276 (26%), Positives = 122/276 (44%), Gaps = 25/276 (9%) Query: 47 VNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDA 106 V G+ KNP+ A+G +G D + G+I + T+TP + G PR+ DA Sbjct: 6 VTVGGVRMKNPVMPASGSIAEGMA-DVVDLGRLGAIVLKTITPDLRQGVKPPRVVEYTDA 64 Query: 107 EGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGK-NKDTPVEQGKDDYLICMEKIYAY 165 + +G + G D L+ N +D I + DT + GK I +I A Sbjct: 65 T--LFSIGIPSKGPDYLL-NHTVPFFDKFGPPVIASISADTVEDFGKLAGYITDPRIAA- 120 Query: 166 AGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMH-HKYVPIAVKIAPDLSE 224 I NIS PN LR +D + +A + AM + +PI K+ P++ + Sbjct: 121 ---IEANISCPN---LRAHGRAFGMDPVASA-----QVITAMKANTTLPIWAKLTPNVGD 169 Query: 225 EELIQVADSLVRHNIDGVIATNTTLDRSL---VQGMKNCDQTGGLSGRPLQLKSTEIIRR 281 + ++A + D VI N L ++ + + GGL+G ++ ++ + Sbjct: 170 --IAEMARCVEGAGADAVITANAILGMAIDAETMTPRLGNVVGGLTGPAVKPVILRMVNQ 227 Query: 282 LSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQI 317 + + ++P+IG GGI + E + AGAS VQI Sbjct: 228 CAEAV--KIPVIGCGGIATGEDVVEYMLAGASAVQI 261 >UniRef50_C4IB41 Dihydroorotate dehydrogenase family protein n=4 Tax=Clostridiales RepID=C4IB41_CLOBU Length = 362 Score = 45.4 bits (106), Expect = 0.003, Method: Compositional matrix adjust. Identities = 72/299 (24%), Positives = 138/299 (46%), Gaps = 47/299 (15%) Query: 52 LTFKNPLGLAAG-LDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLF----RLVDA 106 + +NPL A+G L D + + AL G G++ T++ + + +P ++ +++A Sbjct: 10 IKLENPLMPASGPLVGDKDKMSALNEFGVGAMVTKTISSK-KAEVVRPCIYGGKNFIMNA 68 Query: 107 EGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYA 166 E L + + +D + ++KK D L I++G K+ ++LI ++A A Sbjct: 69 E-LWSEYA-PEVWIDEFLPSIKKELKDKPLIISVGYTKEDM------EFLIPKLDVFADA 120 Query: 167 GYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEE 226 I+ T G+ L ++ +K + Q P+ +K++P + + Sbjct: 121 FEIS------------THYVGKDLSNIKETLKTIRRFTQK------PVFMKMSPHIPDP- 161 Query: 227 LIQVADSLVRHNIDGVIATNT---TLD-----RSLVQGMKNCD-QTGGLSGRPLQLKSTE 277 I A ++ + G++A N+ T++ RS++ G K + T G + +P+ L Sbjct: 162 -IGFAKMVIENKGSGIVAINSLGPTMNIDIDKRSVLIGNKEGEVWTSGPAIKPMALALIH 220 Query: 278 IIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 I++ E IIGVGGI S E + AGAS VQ+ S + KG L ++++ + Sbjct: 221 KIKKAVPECE----IIGVGGISSADDIIEFLLAGASAVQMLSAAMLKGKDLYEKLIEEL 275 >UniRef50_O29513 Dihydroorotate dehydrogenase n=3 Tax=Archaeoglobaceae RepID=PYRD_ARCFU Length = 299 Score = 45.1 bits (105), Expect = 0.003, Method: Compositional matrix adjust. Identities = 69/288 (23%), Positives = 123/288 (42%), Gaps = 43/288 (14%) Query: 51 GLTFKNPLGLAAGLDKDGECIDALG--AMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEG 108 GL KNPL LA+G+ G + +L A G++ +V + G P + G Sbjct: 10 GLRMKNPLMLASGIM--GSKVHSLNLIARDAGAVVTKSVGVEEREGYRNPTVVNW--KCG 65 Query: 109 LINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGY 168 LIN +G + + E +K + L I++ + D + + ++ Y Sbjct: 66 LINAVGLASPAAKDFAEELKDYTNEAPLLISLYGHSVEEFSDLVDTFDSALPYLHGYE-- 123 Query: 169 IAINISSPNTPGLRTLQYGEALD---DLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEE 225 +N+S P+ G L G L+ ++ +K K + P+ K++ + Sbjct: 124 --LNLSCPHVKG-AGLDIGMDLELSAAIVEELKGKTKN---------PVFAKLS---AMH 168 Query: 226 ELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKN---------CDQTGGLSGRPLQLKST 276 + +++A L +DG+ +NT ++GMK + +GG+SG ++ + Sbjct: 169 DYLKLAKVLEDAGVDGITISNT------LRGMKIDIMSGKPVLSNLSGGVSGPAIKPIAL 222 Query: 277 EIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFK 324 + + L E+ +PI+G GGI S E I AGA VQI S + Sbjct: 223 KCVYDLYKEI--EVPIVGCGGITSFEDVLEFIMAGARAVQIGSAVYYS 268 >UniRef50_A6CMG8 Putative uncharacterized protein n=1 Tax=Bacillus sp. SG-1 RepID=A6CMG8_9BACI Length = 587 Score = 44.7 bits (104), Expect = 0.004, Method: Compositional matrix adjust. Identities = 40/136 (29%), Positives = 64/136 (47%), Gaps = 15/136 (11%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGTP-----FEALVRQK-VPAKPVNCMGLTFK 55 Y+ + L +L P + EF + + RI P L R++ P+ + GLTF Sbjct: 6 YHVIFKPILNKLSPVTSREFIHKGMNRIASLPCGPHIINFLGREESFPSLSRHIDGLTFS 65 Query: 56 NPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGF 115 NP+GL+ +D A +GFG +EIG V+ + P LVD E L ++ F Sbjct: 66 NPVGLSGKVDPFLSGTKAFANLGFGFLEIGPVSLQGTKNLSDP----LVDYEDL--QICF 119 Query: 116 ---NNLGVDNLVENVK 128 +LG+ ++ E +K Sbjct: 120 PEGESLGLKSVTERLK 135 >UniRef50_C1EGR6 Predicted protein n=8 Tax=Viridiplantae RepID=C1EGR6_9CHLO Length = 434 Score = 44.3 bits (103), Expect = 0.006, Method: Compositional matrix adjust. Identities = 42/178 (23%), Positives = 79/178 (44%), Gaps = 19/178 (10%) Query: 171 INISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQV 230 IN S P+ G+ + G A+ T + ++ + VP+ K+ P++++ + + Sbjct: 195 INFSCPH--GMPERKMGAAMGQDCTVLDEVCGWVKEV--ATVPVWAKMTPNITD--ITEP 248 Query: 231 ADSLVRHNIDGVIATNTTLD-----------RSLVQGMKNCDQTGGLSGRPLQL-KSTEI 278 A+ + +DG+ A NT + V+G + RP+ L K I Sbjct: 249 ANVCLEKGMDGIAAINTIMSIMGVNLDTLAPEPCVEGHSTPGGYSYKAVRPIALAKCMAI 308 Query: 279 IRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + + E R + G+GGID+ A E I G+ VQ+ +G + G PL++ + + Sbjct: 309 AQMIKKEFPDRT-LSGIGGIDTGGHAAEFILLGSDTVQVCTGVMIHGYPLVQNLCAEL 365 >UniRef50_A3DL41 Dihydroorotate dehydrogenase family protein n=1 Tax=Staphylothermus marinus F1 RepID=A3DL41_STAMF Length = 406 Score = 44.3 bits (103), Expect = 0.006, Method: Compositional matrix adjust. Identities = 79/312 (25%), Positives = 122/312 (39%), Gaps = 31/312 (9%) Query: 47 VNCMGLTFKNPL-GLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVD 105 V GL KNPL A + +D E + AL G G++ T++ RP PR Sbjct: 6 VEIAGLKMKNPLMNAACPVSRDAEMMKALIDNGVGAVVAKTISVRPA---IVPRPSMGAV 62 Query: 106 AEGLINRMGFNNLGVDNL-VENVKKAHYDGVLGI-NIGKNKDTPVEQG-KDDYLICMEKI 162 G++ G N+ + N +Y + + N D P E + +Y I K Sbjct: 63 DRGIVRSQILKTFGPGNVRIVNADSGNYRFIYALLNAELWSDIPAEHYFEREYPIV--KK 120 Query: 163 YAYAGYIAINISSPNTP------GLRTLQYGEALDDLLTAIKNKQ-----NDLQAMHHKY 211 YA + IS P G + + G + T K +A+ Sbjct: 121 YAEEKGVPFIISIGYKPEELQLLGPKCQKAGANAIEFSTHYIGKDYRPVVEAAKALREVV 180 Query: 212 -VPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNT---TLDRSLVQGMK---NCDQTG 264 +PI K++P + ++ L + +DG++ATNT L + G+ + G Sbjct: 181 DIPIFAKLSP--FTPNIPELVKELEKVGVDGIVATNTIGPALHIDIETGLPIVGGPNGYG 238 Query: 265 GLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFK 324 +SG LK + N LP+IGVGGI E AGAS VQI + + + Sbjct: 239 WMSGP--ALKPLALAVVAEAAKNTHLPVIGVGGISKGTDVIEYFMAGASAVQICTAALIE 296 Query: 325 GPPLIKEIVTHI 336 G + + I I Sbjct: 297 GLGVFRRIEKEI 308 >UniRef50_B5YA20 Dihydroorotate dehydrogenase (Dihydroorotate oxidase)(Dhodehase) (Dhodase) (Dhod) n=1 Tax=Coprothermobacter proteolyticus DSM 5265 RepID=B5YA20_COPPD Length = 274 Score = 44.3 bits (103), Expect = 0.007, Method: Compositional matrix adjust. Identities = 73/306 (23%), Positives = 130/306 (42%), Gaps = 46/306 (15%) Query: 44 AKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRL 103 A V LT KNP ++G + D + FG+ T+T P+ GN PRL Sbjct: 2 AGAVRLKKLTLKNPFIASSGTCGYADA-DLIPLDKFGAAVTKTITLLPRQGNRPPRLVE- 59 Query: 104 VDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIY 163 GL+N +G N+G++ + + L +++G + +D+ +E++ Sbjct: 60 -TPAGLVNSIGLQNMGLEAFKQFLTDFKKPTTLIVSVGG-------ESPEDFATIVEELN 111 Query: 164 AY--AGYIAINISSPNTPGLRTLQYGEAL-DDLLTAIKNKQNDLQA-MHHKYVPIAVKIA 219 Y +N+S PN GE + D +T N L+A + P+ VK++ Sbjct: 112 TYDLIDAFELNLSCPNVK-----TGGEVVGKDYVTV----SNILEASLKSTTKPLLVKLS 162 Query: 220 PDLSEEELIQVADSLVRH---NIDGVIATNT--TLDRSLVQGMKNCDQ-TGGLSG---RP 270 P + D +++H ++ + NT +D G +GGLSG P Sbjct: 163 P------FTEQLDKILQHWESKVEAFVLFNTFPAMDIDPRSGKPVLGAVSGGLSGPAIYP 216 Query: 271 LQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIK 330 + L S I + S ++ GGI + A++ I AGA ++I +G ++ P I+ Sbjct: 217 IVLNS---IYKYSKAHT----LVASGGIATTDIAKKFIMAGARALEIGTGNLWN-PAFIE 268 Query: 331 EIVTHI 336 ++ + Sbjct: 269 MLLKEV 274 >UniRef50_A0ADR6 Putative hihydroorotate dehydrogenase n=1 Tax=Streptomyces ambofaciens ATCC 23877 RepID=A0ADR6_STRAM Length = 297 Score = 43.9 bits (102), Expect = 0.008, Method: Compositional matrix adjust. Identities = 67/284 (23%), Positives = 121/284 (42%), Gaps = 43/284 (15%) Query: 50 MGLTFKNPLGLAAGLDKDGE-CIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEG 108 +GL +P+ + +GL D E I L G ++ T+ P P P ++ RL RL G Sbjct: 8 LGLRLSSPVVVGSGLLTDQERNIRRLFDDGASAVVTKTIHPDPGPAGEE-RLLRL--PTG 64 Query: 109 LINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGY 168 ++N ++ V + +++ DG L + + ++P D L + + AG Sbjct: 65 MLNSTTYSRRPVGDWCAMLRRFADDG-LPVIASVHAESP------DELAELADLVGQAGS 117 Query: 169 IAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELI 228 A+ + G+ L G LDD + + ++ VP +VK+A + E L Sbjct: 118 PALEL------GISCLNEGGGLDDTPERVAAYTDAVR--RRTPVPFSVKLA---AGERLR 166 Query: 229 QVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTG--------GLSG---RPLQLKSTE 277 + ++ + D + ++T V G+ TG G SG +PL L Sbjct: 167 ERVEAALACGADAITLSDT------VAGLAVDADTGEVRLGGAFGYSGAGIKPLVLAEIF 220 Query: 278 IIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGF 321 +RR L + P++ GG+++ E ++ GA VQ+Y+ Sbjct: 221 GLRRAGLTV----PVMASGGVENGRDVAEYLSVGADAVQVYTAL 260 >UniRef50_C1TMB2 Dihydroorotate dehydrogenase family protein n=1 Tax=Dethiosulfovibrio peptidovorans DSM 11002 RepID=C1TMB2_9BACT Length = 304 Score = 43.5 bits (101), Expect = 0.011, Method: Compositional matrix adjust. Identities = 58/246 (23%), Positives = 106/246 (43%), Gaps = 20/246 (8%) Query: 80 GSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLV-ENVKKAHYDGVLGI 138 G++ +T P+ GN R++ GL+N +G N G+D+ V E + K G+ Sbjct: 40 GAVCSKAITESPKDGNPGHRIWE--TPCGLLNSIGLQNTGIDDFVDEKIPKLKS---YGV 94 Query: 139 NIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIK 198 I N E+G + + ++ I +N+S PN + +G ++ + Sbjct: 95 PIIANVSMEDERGLALIVERLVEVADCVDAIELNVSCPNVDK-GCMSWG------VSPVL 147 Query: 199 NKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSL-VQGM 257 Q P+ VK+ P + E VA + D ++ NT L ++ V Sbjct: 148 TSQAVSMVQKIWKGPLWVKMTPQAPDPE--GVARAAEDSGADALVVANTWLGMAIDVDSR 205 Query: 258 KNC-DQT-GGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLV 315 K D+ G SG + + ++ ++S ++ +P+IG GG+ S I AGA+ V Sbjct: 206 KAVFDRVVAGFSGPAVFPMALRLVWQVSSAVS--IPVIGCGGVSSGRDLLSMIMAGATAV 263 Query: 316 QIYSGF 321 ++ +G Sbjct: 264 ELGTGM 269 >UniRef50_B0EHW2 Dihydropyrimidine dehydrogenase, putative n=2 Tax=Entamoeba RepID=B0EHW2_ENTDI Length = 901 Score = 43.1 bits (100), Expect = 0.014, Method: Compositional matrix adjust. Identities = 36/136 (26%), Positives = 66/136 (48%), Gaps = 16/136 (11%) Query: 211 YVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQ---------GMKNCD 261 ++P+ K+ P++ E ++A + +R GV NT S + G++ Sbjct: 618 HIPVYPKLTPNVGNIE--ELAAAAMRGGASGVSTINTVFGISEITLSGHPWPQVGVERNT 675 Query: 262 QTGGLSG---RPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIY 318 +GGLSG RP+ ++ + R + + G L +G+GG+ S A + I GAS+VQ+ Sbjct: 676 ISGGLSGDLVRPIAIRQIAQVLRHNENVRGHL--LGIGGVRSAETAMQLIYTGASVVQMC 733 Query: 319 SGFIFKGPPLIKEIVT 334 S ++ EI++ Sbjct: 734 SSVQKWSYDIVDEIIS 749 >UniRef50_Q12882 Dihydropyrimidine dehydrogenase [NADP+] n=94 Tax=Eukaryota RepID=DPYD_HUMAN Length = 1025 Score = 42.7 bits (99), Expect = 0.016, Method: Compositional matrix adjust. Identities = 49/172 (28%), Positives = 84/172 (48%), Gaps = 32/172 (18%) Query: 166 AGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDL-QAMHHKYVPIAVKIAPDLSE 224 A + +N+S P+ G R + D L ++N + QA+ +P K+ P++++ Sbjct: 662 ADALELNLSCPHGMGERGMGLACGQDPEL--VRNICRWVRQAVQ---IPFFAKLTPNVTD 716 Query: 225 EELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQT-------------GGLSG--- 268 ++ +A + +GV ATNT S + G+K+ D T GG+SG Sbjct: 717 --IVSIARAAKEGGANGVTATNTV---SGLMGLKS-DGTPWPAVGIAKRTTYGGVSGTAI 770 Query: 269 RPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSG 320 RP+ L++ I R L G PI+ GGIDS + + + +GAS++Q+ S Sbjct: 771 RPIALRAVTSIAR---ALPG-FPILATGGIDSAESGLQFLHSGASVLQVCSA 818 >UniRef50_B0UTZ1 Dihydroorotate dehydrogenase n=5 Tax=Pasteurellaceae RepID=B0UTZ1_HAES2 Length = 328 Score = 42.7 bits (99), Expect = 0.018, Method: Compositional matrix adjust. Identities = 49/185 (26%), Positives = 82/185 (44%), Gaps = 22/185 (11%) Query: 169 IAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQ--AMHHKYVPIAVKIAPDLSEEE 226 + INIS PN PG + Y A ++LL + Q L ++ + +PI +KI P + + Sbjct: 144 MEINISCPNMPGEISPAY--AAEELLPYLNALQTTLAKLSLGEEALPIGIKIPPFTYQNQ 201 Query: 227 LIQVADSLVRHNID------GVIATNTTLDRSLV----QGMKNCDQ---TGGLSGRPLQL 273 ++ + L++ + I + TL SLV + + N + GGL+G + Sbjct: 202 YDELINGLLKSLTENKTLPISFITSTNTLGSSLVMQEGKSILNSETGTGIGGLAGTAIHA 261 Query: 274 KSTEIIRRLSLELNGR-----LPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPL 328 S + L L+ L IIGVGG++ AGA+ V + + KG + Sbjct: 262 LSLGNVYTLRQMLDKEPKLKDLQIIGVGGVNDKAGFERMKTAGANFVGLATALGVKGIHV 321 Query: 329 IKEIV 333 EI+ Sbjct: 322 FAEIL 326 >UniRef50_C9XJU2 Dihydroorotate dehydrogenase, catalytic subunit n=5 Tax=Clostridium difficile RepID=C9XJU2_CLODC Length = 361 Score = 42.0 bits (97), Expect = 0.035, Method: Compositional matrix adjust. Identities = 38/126 (30%), Positives = 61/126 (48%), Gaps = 9/126 (7%) Query: 212 VPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTT-----LDRSLVQGMKNCDQTGGL 266 +P+ VK+ P + +E+ A L D + A ++ +D Q + + G L Sbjct: 141 IPVIVKLPPMI--DEIGDFAKKLEEAGADAITACDSVGPAFRIDIETGQPLLGGNGIGYL 198 Query: 267 SGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGP 326 SG ++ + + I + ++N +PIIG+GG S A E I AGA V I S I KG Sbjct: 199 SGETIKPITLQRIYEIKKQVN--IPIIGLGGCVSGDDALEMIMAGADFVGICSVVILKGA 256 Query: 327 PLIKEI 332 +I +I Sbjct: 257 QVISKI 262 >UniRef50_A5VL42 Dihydroorotate oxidase B, catalytic subunit n=14 Tax=Bacteria RepID=A5VL42_LACRD Length = 432 Score = 41.6 bits (96), Expect = 0.037, Method: Compositional matrix adjust. Identities = 37/134 (27%), Positives = 67/134 (50%), Gaps = 17/134 (12%) Query: 212 VPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTT-----LDRSLVQGMKNCD---QT 263 +P+ K+ P+++ ++ V + + DG A NT +D G+ N D Sbjct: 171 LPVLAKMTPNITT--MVPVVKACLEGGADGFSAINTVKSIVDVDLKKKVGLPNIDGKSSV 228 Query: 264 GGLSGR---PLQLKSTEIIRRLS-LELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYS 319 GLSG+ P+ L+ + +R + LE +LPI G+GGI++ A E I GA+ +Q+ + Sbjct: 229 SGLSGKAVKPIALRFLQQLRSAAGLE---QLPISGIGGIETWEDAAEFILLGATTLQVTT 285 Query: 320 GFIFKGPPLIKEIV 333 + G +I ++ Sbjct: 286 AIMEYGYRIIDDLT 299 >UniRef50_B9UIZ1 Putative dehydrogenase n=1 Tax=Streptomyces flavoviridis RepID=B9UIZ1_9ACTO Length = 326 Score = 41.6 bits (96), Expect = 0.041, Method: Compositional matrix adjust. Identities = 66/295 (22%), Positives = 122/295 (41%), Gaps = 50/295 (16%) Query: 43 PAKPVNCMGLTFKNPLGLAAGLDKDGE-CIDALGAMGFGSIEIGTVTPRPQPGNDKPRLF 101 P V +GL+ NP+ + +GL D E I L G G++ T+ P P G D+ R+ Sbjct: 29 PMLEVPILGLSPANPVIVGSGLLTDQERNIRRLLGKGAGAVVTKTIHPSPPQGLDE-RIL 87 Query: 102 RLVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEK 161 RL G++N ++ V+ ++ ++ + D L + + DTP Sbjct: 88 RL--PVGMLNSTTYSKRSVNRWLKTLR-SFADDRLPVIASLHADTP-------------- 130 Query: 162 IYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDL------QAMHHKYVPIA 215 G +A+ T G R L+ G + + +++ D + +P++ Sbjct: 131 -----GELAMLAKDVETTGCRALELGISCLNEEDGLEDDNPDRVYAYTSEVRSKTALPMS 185 Query: 216 VKIAPDLSEEELIQVADS------LVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSG- 268 VK+A + ++ A + + I G + TT G + G SG Sbjct: 186 VKLAVGEGLRDRVRAAIAGGADAITLSDTIAGAAVSPTT-------GRLELNGVFGYSGP 238 Query: 269 --RPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGF 321 +PL L + +R+ + L P++G GG+ S + ++ GAS+ Q+Y+ Sbjct: 239 GLKPLVLAAIWQLRKSGIAL----PVMGCGGVSSGRDVADYLSVGASVAQVYTAL 289 >UniRef50_Q871G0 Related to dihydroorotate dehydrogenase a n=3 Tax=Sordariaceae RepID=Q871G0_NEUCR Length = 404 Score = 40.8 bits (94), Expect = 0.066, Method: Compositional matrix adjust. Identities = 51/205 (24%), Positives = 82/205 (40%), Gaps = 41/205 (20%) Query: 169 IAINISSPNTPGLRTLQYG-EALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEEL 227 + IN+S PN P Y +AL L +K +A +P+ +K P E + Sbjct: 192 MEINLSCPNIPHHPPPAYSRDALVRYLEELKKAIKAAEAEGLPRIPVGLKTPPYTYETQF 251 Query: 228 IQVADSL---------------------VRHNIDGVIATNTT-----------LDRSLVQ 255 + + ++L ++ I + ATNT Q Sbjct: 252 LGLMEALEASASATALASERNKKQEEKELQCPITFLTATNTLGSCLAFTAFTGFTDDFTQ 311 Query: 256 GMKNCDQ-TGGLSGRPLQ---LKSTEIIRRLSLE----LNGRLPIIGVGGIDSVIAAREK 307 D TGGL+G PL L + + +R++ E L R+ IIGVGG+ + Sbjct: 312 AALPTDLGTGGLAGAPLHPLALGNVKTLRKMLDEREKTLGHRIQIIGVGGVLDAQGYKRM 371 Query: 308 IAAGASLVQIYSGFIFKGPPLIKEI 332 AGA +V + SG + +G + +EI Sbjct: 372 RMAGADVVGLASGLLLRGVKVFEEI 396 Searching..................................................done Results from round 2 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_B6J754 Dihydroorotate dehydrogenase n=26 Tax=Proteobact... 422 e-117 UniRef50_B1KDM8 Dihydroorotate dehydrogenase n=26 Tax=Gammaprote... 418 e-115 UniRef50_C0Z506 Dihydroorotate dehydrogenase n=8 Tax=Bacteria Re... 400 e-110 UniRef50_Q2Y5H8 Dihydroorotate dehydrogenase n=195 Tax=cellular ... 400 e-110 UniRef50_B2UNA2 Dihydroorotate dehydrogenase n=8 Tax=Bacteria Re... 391 e-107 UniRef50_A1WJ81 Dihydroorotate dehydrogenase n=250 Tax=Bacteria ... 388 e-106 UniRef50_C9YAQ9 Dihydroorotate dehydrogenase n=2 Tax=cellular or... 383 e-105 UniRef50_P57443 Dihydroorotate dehydrogenase n=2 Tax=Proteobacte... 376 e-103 UniRef50_A9CK85 Dihydroorotate dehydrogenase n=16 Tax=Alphaprote... 376 e-103 UniRef50_A5EV79 Dihydroorotate dehydrogenase n=3 Tax=Gammaproteo... 374 e-102 UniRef50_A6H0L5 Dihydroorotate dehydrogenase n=28 Tax=Bacteria R... 374 e-102 UniRef50_Q3IU78 Dihydroorotate dehydrogenase n=13 Tax=cellular o... 372 e-102 UniRef50_A1WTJ3 Dihydroorotate dehydrogenase n=1 Tax=Halorhodosp... 371 e-101 UniRef50_Q7PYN9 AGAP002037-PA (Fragment) n=10 Tax=cellular organ... 371 e-101 UniRef50_Q5PR57 Dihydroorotate dehydrogenase n=20 Tax=cellular o... 370 e-101 UniRef50_P32748 Dihydroorotate dehydrogenase, mitochondrial n=14... 369 e-101 UniRef50_A7NLW9 Dihydroorotate dehydrogenase n=18 Tax=Bacteria R... 369 e-100 UniRef50_C2QE06 Dihydroorotate dehydrogenase n=3 Tax=Bacillus ce... 368 e-100 UniRef50_A9WDI1 Dihydroorotate dehydrogenase n=13 Tax=Bacteria R... 368 e-100 UniRef50_Q2RX27 Dihydroorotate dehydrogenase n=14 Tax=cellular o... 368 e-100 UniRef50_B0W4C3 Dihydroorotate dehydrogenase, mitochondrial n=2 ... 366 e-100 UniRef50_D2S350 Dihydroorotate dehydrogenase n=2 Tax=Halobacteri... 366 e-100 UniRef50_A5UX75 Dihydroorotate dehydrogenase n=1 Tax=Roseiflexus... 364 2e-99 UniRef50_Q02127 Dihydroorotate dehydrogenase, mitochondrial n=39... 363 4e-99 UniRef50_Q0J918 Os04g0676300 protein n=1 Tax=Oryza sativa Japoni... 358 1e-97 UniRef50_B4UG99 Dihydroorotate dehydrogenase n=23 Tax=Bacteria R... 358 2e-97 UniRef50_Q056I9 Dihydroorotate dehydrogenase n=6 Tax=Leptospira ... 358 2e-97 UniRef50_Q1V0W4 Dihydroorotate dehydrogenase n=5 Tax=Bacteria Re... 356 5e-97 UniRef50_Q9RX14 Dihydroorotate dehydrogenase n=4 Tax=Bacteria Re... 355 1e-96 UniRef50_C6NV76 Dihydroorotate dehydrogenase n=1 Tax=Acidithioba... 355 1e-96 UniRef50_Q2YWG7 Dihydroorotate dehydrogenase n=56 Tax=Staphyloco... 355 1e-96 UniRef50_B6BWI2 Dihydroorotate oxidase n=1 Tax=beta proteobacter... 354 2e-96 UniRef50_B6R4R9 Dihydroorotate oxidase n=1 Tax=Pseudovibrio sp. ... 354 3e-96 UniRef50_B3CMR9 Dihydroorotate dehydrogenase n=10 Tax=Rickettsia... 353 6e-96 UniRef50_A5EA61 Dihydroorotate dehydrogenase n=122 Tax=cellular ... 351 1e-95 UniRef50_B1ZSY3 Dihydroorotate oxidase n=3 Tax=Verrucomicrobia R... 351 2e-95 UniRef50_Q47RF2 Dihydroorotate dehydrogenase n=52 Tax=Bacteria R... 350 4e-95 UniRef50_Q5HL43 Dihydroorotate dehydrogenase n=8 Tax=Staphylococ... 350 5e-95 UniRef50_Q75XR0 Dihydroorotate dehydrogenase n=3 Tax=Eukaryota R... 349 6e-95 UniRef50_A8WW30 C. briggsae CBR-DHOD-1 protein n=3 Tax=Caenorhab... 348 1e-94 UniRef50_B0MVX7 Putative uncharacterized protein n=1 Tax=Alistip... 348 2e-94 UniRef50_Q1GGD3 Dihydroorotate oxidase A n=18 Tax=Alphaproteobac... 347 4e-94 UniRef50_C1EIH8 Dihydropryrimidine dehydrogenase n=1 Tax=Micromo... 346 5e-94 UniRef50_B0CUF5 Predicted protein n=4 Tax=Dikarya RepID=B0CUF5_L... 345 2e-93 UniRef50_C6XQ80 Dihydroorotate dehydrogenase n=1 Tax=Hirschia ba... 344 3e-93 UniRef50_Q30R79 Dihydroorotate dehydrogenase n=10 Tax=Campylobac... 343 5e-93 UniRef50_D1SB76 Dihydroorotate dehydrogenase n=2 Tax=Micromonosp... 342 8e-93 UniRef50_P74782 Dihydroorotate dehydrogenase n=24 Tax=Bacteria R... 342 1e-92 UniRef50_B3DX48 Dihydroorotate dehydrogenase n=1 Tax=Methylacidi... 341 2e-92 UniRef50_B9L4A8 Dihydroorotate oxidase n=2 Tax=Thermomicrobia (c... 339 7e-92 UniRef50_C4QIG2 Dihydroorotate dehydrogenase n=3 Tax=Schistosoma... 339 1e-91 UniRef50_B5Z6I2 Dihydroorotate dehydrogenase n=28 Tax=Campylobac... 339 1e-91 UniRef50_A5U4G5 Dihydroorotate dehydrogenase n=31 Tax=Corynebact... 338 2e-91 UniRef50_P32747 Dihydroorotate dehydrogenase, mitochondrial n=2 ... 337 3e-91 UniRef50_B6KTR1 Dihydroorotate dehydrogenase n=4 Tax=Toxoplasma ... 337 3e-91 UniRef50_B9KHW9 Dihydroorotate dehydrogenase (PyrD) n=10 Tax=Ric... 336 7e-91 UniRef50_A8Q682 Putative uncharacterized protein n=1 Tax=Malasse... 336 9e-91 UniRef50_Q0GF37 Dihydroorotate dehydrogenase n=2 Tax=Ustilago ma... 335 1e-90 UniRef50_D2PV93 Dihydroorotate dehydrogenase n=1 Tax=Kribbella f... 335 1e-90 UniRef50_Q8D370 Dihydroorotate dehydrogenase n=46 Tax=Gammaprote... 335 1e-90 UniRef50_B3L830 Dihydroorotate dehydrogenase, putative n=1 Tax=P... 335 2e-90 UniRef50_Q75CE1 Dihydroorotate dehydrogenase, mitochondrial n=9 ... 334 2e-90 UniRef50_Q827Q6 Dihydroorotate dehydrogenase n=12 Tax=Actinomyce... 334 3e-90 UniRef50_B7JXU8 Dihydroorotate dehydrogenase n=8 Tax=Cyanobacter... 333 4e-90 UniRef50_Q5UF20 Predicted dihydroorotate dehydrogenase n=1 Tax=u... 333 5e-90 UniRef50_C3XDT6 Dihydroorotate dehydrogenase n=4 Tax=Helicobacte... 332 7e-90 UniRef50_Q2GEM2 Dihydroorotate dehydrogenase n=2 Tax=Neoricketts... 331 3e-89 UniRef50_D2UZD6 Predicted protein n=1 Tax=Naegleria gruberi RepI... 330 4e-89 UniRef50_A2VBP6 Dihydroorotate dehydrogenase, mitochondrial n=1 ... 330 5e-89 UniRef50_A9HBE5 Dihydroorotate oxidase n=10 Tax=Acetobacteraceae... 327 4e-88 UniRef50_Q2S001 Dihydroorotate oxidase n=2 Tax=Rhodothermaceae R... 326 7e-88 UniRef50_D1B1W1 Dihydroorotate dehydrogenase n=2 Tax=Campylobact... 322 1e-86 UniRef50_B9L9P6 Dihydroorotate dehydrogenase n=7 Tax=Epsilonprot... 321 2e-86 UniRef50_A7AUQ8 Dihydroorotate dehydrogenase n=2 Tax=Piroplasmid... 321 2e-86 UniRef50_Q7RLG4 Dihydroorotate dehydrogenase, putative n=2 Tax=P... 320 4e-86 UniRef50_Q6SZS6 Dihydroorotate dehydrogenase, mitochondrial n=10... 319 8e-86 UniRef50_Q83GM4 Dihydroorotate oxidase n=2 Tax=Tropheryma whippl... 317 2e-85 UniRef50_A5K1N1 Dihydroorotate dehydrogenase, mitochondrial, put... 315 2e-84 UniRef50_Q7U3U2 Dihydroorotate dehydrogenase n=30 Tax=cellular o... 315 2e-84 UniRef50_Q08210 Dihydroorotate dehydrogenase homolog, mitochondr... 313 5e-84 UniRef50_Q5KK62 Dihydroorotate dehydrogenase, mitochondrial, put... 311 3e-83 UniRef50_C0W1V7 Possible dihydroorotate oxidase n=1 Tax=Actinomy... 309 7e-83 UniRef50_B7G8S8 Predicted protein n=2 Tax=Bacillariophyta RepID=... 309 9e-83 UniRef50_C6IFT5 Dihydroorotate dehydrogenase 2 n=7 Tax=Bacteroid... 308 1e-82 UniRef50_A9F3A8 PyrD protein n=1 Tax=Sorangium cellulosum 'So ce... 306 1e-81 UniRef50_C7NF21 Dihydroorotate oxidase A n=1 Tax=Kytococcus sede... 304 2e-81 UniRef50_B5CXJ8 Putative uncharacterized protein n=3 Tax=Bactero... 302 2e-80 UniRef50_D0IRU1 Dihydroorotate dehydrogenase n=1 Tax=Helicobacte... 301 3e-80 UniRef50_C2BWU0 Possible dihydroorotate oxidase n=3 Tax=Mobilunc... 299 9e-80 UniRef50_C5K5A0 Dihydroorotate dehydrogenase, putative n=2 Tax=P... 299 1e-79 UniRef50_D1CE91 Dihydroorotate dehydrogenase n=1 Tax=Thermobacul... 298 2e-79 UniRef50_Q6MPX3 PyrD protein n=1 Tax=Bdellovibrio bacteriovorus ... 294 2e-78 UniRef50_D1ZM19 Whole genome shotgun sequence assembly, scaffold... 290 4e-77 UniRef50_A7BDH3 Putative uncharacterized protein n=1 Tax=Actinom... 288 2e-76 UniRef50_B2B417 Predicted CDS Pa_6_7920 n=3 Tax=Sordariomycetes ... 288 2e-76 UniRef50_A3ZNL9 Dihydroorotate dehydrogenase n=2 Tax=Planctomyce... 285 1e-75 UniRef50_UPI00016B255A dihydroorotate dehydrogenase 2 n=4 Tax=ca... 281 2e-74 UniRef50_Q2H299 Putative uncharacterized protein n=3 Tax=cellula... 280 6e-74 UniRef50_C6A9A6 Dihydroorotate dehydrogenase 2 n=20 Tax=Bifidoba... 276 8e-73 UniRef50_A2QCB1 Catalytic activity: n=26 Tax=Leotiomyceta RepID=... 260 5e-68 UniRef50_Q4N5X1 Dihydroorotate dehydrogenase, putative n=1 Tax=T... 247 6e-64 UniRef50_UPI00016B240E dihydroorotate dehydrogenase 2 n=1 Tax=ca... 240 5e-62 UniRef50_B2V726 Dihydroorotate dehydrogenase n=2 Tax=Aquificales... 235 1e-60 UniRef50_Q2IVE7 Dihydroorotate oxidase B, catalytic subunit n=1 ... 235 2e-60 UniRef50_C0QU30 Dihydroorotate dehydrogenase, catalytic subunit ... 233 7e-60 UniRef50_Q00YC9 Dihydroorotate dehydrogenase (ISS) (Fragment) n=... 229 1e-58 UniRef50_B0TGQ8 Dihydroorotate dehydrogenase n=32 Tax=Bacteria R... 228 2e-58 UniRef50_A4IM35 Dihydroorotate dehydrogenase n=348 Tax=Bacteria ... 227 5e-58 UniRef50_A6L5H1 Dihydroorotate dehydrogenase n=7 Tax=Bacteroidal... 226 1e-57 UniRef50_O27281 Dihydroorotate dehydrogenase n=20 Tax=Euryarchae... 224 4e-57 UniRef50_A9BJH4 Dihydroorotate dehydrogenase n=45 Tax=Bacteria R... 223 8e-57 UniRef50_C8WHP0 Dihydroorotate dehydrogenase family protein n=3 ... 222 1e-56 UniRef50_C8W700 Dihydroorotate dehydrogenase family protein n=2 ... 220 4e-56 UniRef50_Q1G992 Dihydroorotate dehydrogenase n=3 Tax=Lactobacill... 220 6e-56 UniRef50_C0QYH6 Dihydroorotate dehydrogenase n=2 Tax=Brachyspira... 219 9e-56 UniRef50_C4F860 Putative uncharacterized protein n=2 Tax=Collins... 218 3e-55 UniRef50_B2WMQ8 Dihydroorotate dehydrogenase, mitochondrial n=3 ... 216 8e-55 UniRef50_C9KKE5 Dihydroorotate oxidase n=6 Tax=Bacteria RepID=C9... 215 1e-54 UniRef50_A6G037 Dihydroorotate dehydrogenase 1 n=1 Tax=Plesiocys... 215 2e-54 UniRef50_Q3AC05 Dihydroorotate dehydrogenase n=1 Tax=Carboxydoth... 215 2e-54 UniRef50_Q2NEG1 PyrD n=1 Tax=Methanosphaera stadtmanae DSM 3091 ... 215 2e-54 UniRef50_A4ECL7 Putative uncharacterized protein n=1 Tax=Collins... 213 5e-54 UniRef50_B5YJH1 Dihydroorotate dehydrogenase n=24 Tax=Bacteria R... 213 7e-54 UniRef50_C9RJ75 Dihydroorotate oxidase n=1 Tax=Fibrobacter succi... 213 9e-54 UniRef50_Q01YA2 Dihydroorotate dehydrogenase n=5 Tax=Bacteria Re... 212 2e-53 UniRef50_C6SRR7 Putative dihydroorotate dehydrogenase dihydrooro... 212 2e-53 UniRef50_B5YFH3 Dihydroorotate dehydrogenase n=2 Tax=Dictyoglomu... 212 2e-53 UniRef50_Q979G6 Dihydroorotate dehydrogenase n=4 Tax=Thermoplasm... 212 2e-53 UniRef50_Q0W8E1 Dihydroorotate dehydrogenase n=18 Tax=Euryarchae... 208 3e-52 UniRef50_A9A3M4 Dihydroorotate dehydrogenase family protein n=2 ... 207 5e-52 UniRef50_B1MZ73 Dihydroorotate dehydrogenase B, catalytic subuni... 207 5e-52 UniRef50_C6A1L2 Dihydroorotate dehydrogenase family protein n=1 ... 207 6e-52 UniRef50_B1I4M6 Dihydroorotate dehydrogenase n=73 Tax=Bacteria R... 206 8e-52 UniRef50_B9TAL5 Dihydroorotate dehydrogenase, putative n=1 Tax=R... 206 8e-52 UniRef50_B1GYY3 Dihydroorotate dehydrogenase n=1 Tax=uncultured ... 206 9e-52 UniRef50_D1JFH0 Dihydroorotate dehydrogenase electron transfer s... 205 2e-51 UniRef50_Q0B324 Dihydroorotate oxidase B, catalytic subunit n=8 ... 203 7e-51 UniRef50_D1YYV3 Dihydroorotate dehydrogenase n=1 Tax=Methanocell... 203 8e-51 UniRef50_C2D6B3 Dihydroorotate oxidase n=1 Tax=Atopobium vaginae... 203 8e-51 UniRef50_Q1MQG1 Dihydroorotate dehydrogenase n=2 Tax=Deltaproteo... 203 1e-50 UniRef50_C1A4J6 Dihydroorotate dehydrogenase n=1 Tax=Gemmatimona... 202 1e-50 UniRef50_Q3B2I1 Dihydroorotate oxidase B, catalytic subunit n=12... 200 5e-50 UniRef50_B8D3W9 Dihydroorotate dehydrogenase, PyrD n=1 Tax=Desul... 198 2e-49 UniRef50_C5R8W8 Dihydroorotate dehydrogenase B, catalytic subuni... 198 2e-49 UniRef50_P28272 Dihydroorotate dehydrogenase n=168 Tax=cellular ... 197 4e-49 UniRef50_A0NIQ6 Dihydroorotate dehydrogenase A n=7 Tax=Lactobaci... 195 2e-48 UniRef50_Q1Q4L5 Similar to dihydroorotate oxidase (Dihydroorotat... 194 5e-48 UniRef50_D2RBF2 Dihydroorotate dehydrogenase 1B n=21 Tax=Bifidob... 193 8e-48 UniRef50_Q8TXU6 Dihydroorotate dehydrogenase n=1 Tax=Methanopyru... 190 5e-47 UniRef50_A6BB63 Dihydroorotate dehydrogenase n=1 Tax=Vibrio para... 190 7e-47 UniRef50_C9M6H2 Dihydroorotate oxidase n=2 Tax=Synergistaceae Re... 189 9e-47 UniRef50_A8MCA1 Dihydroorotate oxidase n=1 Tax=Caldivirga maquil... 188 3e-46 UniRef50_A9D5Y9 Dihydroorotate dehydrogenase n=1 Tax=Shewanella ... 187 5e-46 UniRef50_D0JBI0 Dihydroorotate dehydrogenase n=2 Tax=Blattabacte... 185 2e-45 UniRef50_A1RZC9 Dihydroorotate oxidase B, catalytic subunit n=2 ... 183 1e-44 UniRef50_A5IK84 Dihydroorotate dehydrogenase n=10 Tax=Thermotoga... 181 2e-44 UniRef50_C0ZGG5 Hypothetical membrane protein n=1 Tax=Brevibacil... 181 3e-44 UniRef50_C0WNB5 Dihydroorotate dehydrogenase n=3 Tax=Lactobacill... 181 3e-44 UniRef50_A3DM44 Dihydroorotate oxidase B, catalytic subunit n=1 ... 181 3e-44 UniRef50_D0U5Z4 Dihydroorotate dehydrogenase subfamily 1 family ... 181 4e-44 UniRef50_Q73P17 Dihydroorotate dehydrogenase/oxidoreductase, FAD... 180 5e-44 UniRef50_Q1AVZ1 Dihydroorotate oxidase B, catalytic subunit n=1 ... 180 5e-44 UniRef50_C7M0V6 Dihydroorotate dehydrogenase family protein n=1 ... 180 7e-44 UniRef50_Q0CXV7 Putative uncharacterized protein n=1 Tax=Aspergi... 178 2e-43 UniRef50_Q9YFI6 Dihydroorotate dehydrogenase n=3 Tax=Desulfuroco... 178 3e-43 UniRef50_A6DND8 Dihydroorotate dehydrogenase n=1 Tax=Lentisphaer... 174 4e-42 UniRef50_A9BIU8 Dihydroorotate dehydrogenase family protein n=10... 168 3e-40 UniRef50_O08358 Dihydroorotate dehydrogenase n=12 Tax=Sulfolobac... 166 1e-39 UniRef50_A8MJK5 Dihydroorotate dehydrogenase family protein n=1 ... 165 2e-39 UniRef50_B0PGY1 Putative uncharacterized protein n=1 Tax=Anaerot... 156 1e-36 UniRef50_A4FBL7 Dihydroorotate dehydrogenase n=1 Tax=Saccharopol... 154 5e-36 UniRef50_C5CHS6 Dihydroorotate dehydrogenase family protein n=1 ... 154 6e-36 UniRef50_A5AEM5 Putative uncharacterized protein n=1 Tax=Vitis v... 150 9e-35 UniRef50_C6QGW0 Dihydroorotate dehydrogenase n=1 Tax=Hyphomicrob... 144 5e-33 UniRef50_UPI000187EFAF hypothetical protein MPER_16226 n=1 Tax=M... 141 4e-32 UniRef50_B8D2W4 Dihydroorotate dehydrogenase family protein n=1 ... 140 7e-32 UniRef50_B3P4V6 GG16516 n=3 Tax=cellular organisms RepID=B3P4V6_... 139 1e-31 UniRef50_A4WLH6 Dihydroorotate dehydrogenase n=5 Tax=Thermoprote... 129 1e-28 UniRef50_Q4DGY9 Dihydroorotate dehydrogenase, putative n=1 Tax=T... 127 5e-28 UniRef50_A8QCU3 Dihydroorotate dehydrogenase, mitochondrial, put... 121 4e-26 UniRef50_A4VL83 Phosphoserine aminotransferase n=1 Tax=Pseudomon... 117 7e-25 UniRef50_A0DS83 Chromosome undetermined scaffold_61, whole genom... 108 3e-22 UniRef50_UPI0000D54A55 dihydroorotate dehydrogenase n=1 Tax=Psyc... 107 6e-22 Sequences not found previously or not previously below threshold: UniRef50_Q3J7C7 Dihydroorotate oxidase B, catalytic subunit n=10... 200 7e-50 UniRef50_O29513 Dihydroorotate dehydrogenase n=3 Tax=Archaeoglob... 194 4e-48 UniRef50_C1TMB2 Dihydroorotate dehydrogenase family protein n=1 ... 191 4e-47 UniRef50_A0LUF8 Dihydroorotate oxidase B, catalytic subunit n=6 ... 184 4e-45 UniRef50_UPI0001C31DA9 dihydroorotate dehydrogenase family prote... 173 6e-42 UniRef50_B7RZ94 Dihydroorotate dehydrogenase family protein n=3 ... 172 2e-41 UniRef50_B5YA20 Dihydroorotate dehydrogenase (Dihydroorotate oxi... 170 8e-41 UniRef50_A3U0T3 Probable dihydroorotate dehydrogenase, catalytic... 169 1e-40 UniRef50_D2QWH7 Dihydroorotate dehydrogenase family protein n=6 ... 166 8e-40 UniRef50_B0VIM3 Dihydroorotate dehydrogenase, catalytic subunit ... 161 2e-38 UniRef50_D1B5N0 Dihydroorotate dehydrogenase family protein n=1 ... 155 3e-36 UniRef50_B7G610 Predicted protein n=2 Tax=Bacillariophyta RepID=... 153 1e-35 UniRef50_A0Z3E6 Dihydroorotate dehydrogenase/oxidoreductase, FAD... 153 1e-35 UniRef50_C6Q0J2 Dihydroorotate dehydrogenase family protein n=1 ... 149 1e-34 UniRef50_A5VL42 Dihydroorotate oxidase B, catalytic subunit n=14... 146 1e-33 UniRef50_Q12882 Dihydropyrimidine dehydrogenase [NADP+] n=94 Tax... 145 2e-33 UniRef50_P25889 Uncharacterized protein yeiA n=116 Tax=Bacteria ... 144 6e-33 UniRef50_Q9LVI9 Senescencs-related protein; dihydroorotate dehyd... 143 7e-33 UniRef50_C1EGR6 Predicted protein n=8 Tax=Viridiplantae RepID=C1... 143 8e-33 UniRef50_A6LJ97 Dihydroorotate dehydrogenase family protein n=2 ... 142 1e-32 UniRef50_C4IB41 Dihydroorotate dehydrogenase family protein n=4 ... 134 5e-30 UniRef50_A9GKC4 Dihydropyrimidine dehydrogenase n=5 Tax=Bacteria... 132 1e-29 UniRef50_C9XJU2 Dihydroorotate dehydrogenase, catalytic subunit ... 132 2e-29 UniRef50_A0CDX9 Chromosome undetermined scaffold_17, whole genom... 128 4e-28 UniRef50_C1TLU5 Dihydroorotate dehydrogenase family protein n=1 ... 127 6e-28 UniRef50_A3DL41 Dihydroorotate dehydrogenase family protein n=1 ... 126 1e-27 UniRef50_UPI0001968A99 hypothetical protein BACCELL_01888 n=1 Ta... 122 2e-26 UniRef50_B3E2T4 Dihydroorotate dehydrogenase family protein n=1 ... 121 3e-26 UniRef50_Q7N0H1 Similar to dihydroorotate dehydrogenase PyrD n=1... 119 1e-25 UniRef50_B0EHW2 Dihydropyrimidine dehydrogenase, putative n=2 Ta... 117 5e-25 UniRef50_B9UIZ1 Putative dehydrogenase n=1 Tax=Streptomyces flav... 117 6e-25 UniRef50_A2EKA7 Dihydroorotate dehydrogenase family protein n=3 ... 116 1e-24 UniRef50_Q01P61 Dihydropyrimidine dehydrogenase (NADP+) / dihydr... 116 1e-24 UniRef50_A0ADR6 Putative hihydroorotate dehydrogenase n=1 Tax=St... 116 1e-24 UniRef50_UPI0001791DE1 PREDICTED: similar to dihydropyrimidine d... 115 2e-24 UniRef50_Q23YG3 Dihydroorotate dehydrogenase family protein n=1 ... 114 5e-24 UniRef50_C3KS38 Putative hihydroorotate dehydrogenase n=2 Tax=Cl... 109 2e-22 UniRef50_UPI00016C5774 dihydroorotate dehydrogenase 2 n=1 Tax=Ge... 109 2e-22 UniRef50_B0P959 Putative uncharacterized protein n=1 Tax=Anaerot... 109 2e-22 UniRef50_A2ELU8 Dihydroorotate dehydrogenase family protein n=3 ... 109 2e-22 UniRef50_P07670 Dihydroorotate dehydrogenase n=1 Tax=Dictyosteli... 107 8e-22 UniRef50_Q972L2 350aa long hypothetical dihydroorotate dehydroge... 105 2e-21 UniRef50_A8F8E8 Dihydroorotate dehydrogenase n=1 Tax=Thermotoga ... 104 4e-21 UniRef50_A6CFX5 Putative uncharacterized protein n=1 Tax=Plancto... 103 9e-21 UniRef50_A8L1Y0 Dihydroorotate oxidase n=4 Tax=Frankia RepID=A8L... 103 1e-20 UniRef50_Q871G0 Related to dihydroorotate dehydrogenase a n=3 Ta... 101 5e-20 UniRef50_UPI0001C36786 dihydroorotate dehydrogenase family prote... 98 3e-19 UniRef50_C0CVL1 Putative uncharacterized protein n=1 Tax=Clostri... 98 4e-19 UniRef50_A3ETM0 Dihydroorotate dehydrogenase n=3 Tax=Leptospiril... 96 2e-18 UniRef50_A8PKY4 Dihydroorotate dehydrogenase (Dihydroorotate oxi... 94 5e-18 UniRef50_D2M1S9 Dihydroorotate dehydrogenase n=1 Tax=Bacillus ce... 91 5e-17 UniRef50_B3E020 Dihydroorotate dehydrogenase fused to Fe-S-clust... 90 8e-17 UniRef50_B8E1W3 Dihydroorotate dehydrogenase n=3 Tax=Bacteria Re... 90 1e-16 UniRef50_B0UTZ1 Dihydroorotate dehydrogenase n=5 Tax=Pasteurella... 89 2e-16 UniRef50_D2Q7Y3 Pyr Dihydroorotate dehydrogenase n=16 Tax=Bacter... 88 4e-16 UniRef50_Q2GYB9 Putative uncharacterized protein n=1 Tax=Chaetom... 88 5e-16 UniRef50_C1SLA1 Dihydroorotate dehydrogenase n=1 Tax=Denitrovibr... 88 6e-16 UniRef50_A9WGL5 Dihydroorotate dehydrogenase n=3 Tax=Chloroflexu... 88 6e-16 UniRef50_B2VR65 Dihydroorotate dehydrogenase n=2 Tax=Pleosporine... 87 1e-15 UniRef50_A7NSB8 Dihydroorotate dehydrogenase n=2 Tax=Roseiflexus... 87 1e-15 UniRef50_Q2BA70 Dihydroorotate dehydrogenase n=1 Tax=Bacillus sp... 87 1e-15 UniRef50_B2B760 Predicted CDS Pa_2_10010 n=1 Tax=Podospora anser... 85 4e-15 UniRef50_B0PC95 Putative uncharacterized protein n=1 Tax=Anaerot... 84 6e-15 UniRef50_D2S9D7 Dihydroorotate oxidase n=1 Tax=Geodermatophilus ... 83 1e-14 UniRef50_A6L9F5 Dihydroorotate dehydrogenase family protein n=9 ... 83 1e-14 UniRef50_Q7UHA6 Dihydroorotate dehydrogenase n=1 Tax=Rhodopirell... 83 1e-14 UniRef50_A7EUV5 Putative uncharacterized protein n=2 Tax=Sclerot... 82 3e-14 >UniRef50_B6J754 Dihydroorotate dehydrogenase n=26 Tax=Proteobacteria RepID=PYRD_COXB1 Length = 347 Score = 422 bits (1086), Expect = e-117, Method: Composition-based stats. Identities = 164/336 (48%), Positives = 223/336 (66%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 M Y ++R LF+L+PE AH T L+ Q+ P KP G+ F NP+GL Sbjct: 1 MIYRYLRPWLFKLEPETAHALTLNCLKWFYCYWLINRRLQRFPQKPTVVFGIEFPNPVGL 60 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAGLDK+GE +D L +GFG IE+G VTP+PQPGN KPR+FRL A LINRMGFNNLGV Sbjct: 61 AAGLDKNGEYMDELLGLGFGFIEVGAVTPKPQPGNSKPRIFRLPQARALINRMGFNNLGV 120 Query: 121 DNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPG 180 D LVE +K+ G++G+NIGKN TP+E+ +DY C EK+Y+Y Y+ INISSPNTP Sbjct: 121 DYLVEQLKRRKVKGIVGVNIGKNLTTPLEKAHEDYQNCFEKLYSYVDYVTINISSPNTPE 180 Query: 181 LRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNID 240 LR LQ L DLLT +K Q L+ +HK VP+ +KIAPDL+ EE+ +A ++H I+ Sbjct: 181 LRQLQSERYLADLLTRLKEDQRRLEDQYHKRVPLFLKIAPDLTPEEIQTIATLALQHRIE 240 Query: 241 GVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDS 300 G++ATNT+ R + + N ++ GGLSG+PL + +++++L L +PI+ VGGI S Sbjct: 241 GIVATNTSCSRQGTEKLPNANEAGGLSGKPLFPMTLQVVKQLHSFLGDEIPIVAVGGIFS 300 Query: 301 VIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 A+ I AGA LVQ+Y+G I++GP L+K IV + Sbjct: 301 GENAQTLINAGARLVQLYTGLIYEGPELVKNIVEFL 336 >UniRef50_B1KDM8 Dihydroorotate dehydrogenase n=26 Tax=Gammaproteobacteria RepID=PYRD_SHEWM Length = 340 Score = 418 bits (1075), Expect = e-115, Method: Composition-based stats. Identities = 213/334 (63%), Positives = 263/334 (78%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 M+Y +K +FQ+DPE+AH F L TP + QK+ PV MG+TF NP+GL Sbjct: 1 MFYKLAQKVMFQMDPEKAHHFALNSLMATANTPLDCFYAQKIAPSPVEFMGVTFPNPVGL 60 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAG+DKDGECID AMGFG IE+GTVTPRPQPGND PRLFRL A+G+INRMGFNN GV Sbjct: 61 AAGMDKDGECIDGFHAMGFGHIEVGTVTPRPQPGNDLPRLFRLKPAKGIINRMGFNNKGV 120 Query: 121 DNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPG 180 DNL+ N+K A ++G+NIGKNKDTPVEQGKDDYLICM+K+Y YA YIA+NISSPNTPG Sbjct: 121 DNLIANLKAAKSGALIGVNIGKNKDTPVEQGKDDYLICMDKVYEYAAYIAVNISSPNTPG 180 Query: 181 LRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNID 240 LR+LQYG+ LDDLL ++K KQ DL H KYVPIA+KIAPDLS+EE+ ++ADSL+++ D Sbjct: 181 LRSLQYGDLLDDLLGSLKAKQKDLAQKHGKYVPIALKIAPDLSDEEIQKIADSLIKNQFD 240 Query: 241 GVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDS 300 G IATNTTL R V G+ N ++TGGLSG+PL L ST +I++LS LNG++PIIGVGGI+S Sbjct: 241 GAIATNTTLSRDGVSGLMNANETGGLSGKPLNLLSTSVIKKLSSCLNGQIPIIGVGGINS 300 Query: 301 VIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVT 334 A +K+ AGAS+VQIYSGFI++GP LIK+I+ Sbjct: 301 AADAIDKLDAGASMVQIYSGFIYQGPKLIKDIIE 334 >UniRef50_C0Z506 Dihydroorotate dehydrogenase n=8 Tax=Bacteria RepID=C0Z506_BREBN Length = 363 Score = 400 bits (1029), Expect = e-110, Method: Composition-based stats. Identities = 160/341 (46%), Positives = 216/341 (63%), Gaps = 6/341 (1%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRIT-GTPFEALVRQ----KVPAKPVNCMGLTFKN 56 Y +RK LFQ D E HE T LR + P +++++ K G+TF N Sbjct: 1 MYQLIRKYLFQQDAEEIHEKTIGALRLVEDSAPGKSILKMIYQVKDQRLENKLWGMTFPN 60 Query: 57 PLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFN 116 P+GLAAG DK+ E ALGA+GFG +EIGT+TP+ QPGN KPRLFRL + + +INRMGFN Sbjct: 61 PVGLAAGFDKNAEVYHALGALGFGFVEIGTLTPQGQPGNPKPRLFRLPEHQAVINRMGFN 120 Query: 117 NLGVDNLVENV-KKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISS 175 N G +++ A+ D +GINIGKNK TP E+ DY CM+ +YAY Y INISS Sbjct: 121 NHGAYLASQHLVDYAYSDVPIGINIGKNKVTPNEEAAVDYSKCMDMLYAYGHYFVINISS 180 Query: 176 PNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLV 235 PNTP LR LQ E+L L+ A+K K +++ K PI +K+APD+S+E + V + V Sbjct: 181 PNTPNLRDLQETESLRHLVRAVKEKATEMEGRSIKKKPILLKVAPDMSDEHMRDVVHAAV 240 Query: 236 RHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGV 295 I G+IATNTTL R V G + ++ GGLSGRPL +ST ++ + E+ ++PIIGV Sbjct: 241 EEGISGIIATNTTLSREAVSGHRFAEEAGGLSGRPLTERSTAWVKEIYQEVGDKVPIIGV 300 Query: 296 GGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 GGI + A KI AGASLVQ+Y+G I++GP + K+I + Sbjct: 301 GGIYNGEDAYAKIRAGASLVQVYTGMIYQGPGIAKQINKKL 341 >UniRef50_Q2Y5H8 Dihydroorotate dehydrogenase n=195 Tax=cellular organisms RepID=PYRD_NITMU Length = 348 Score = 400 bits (1028), Expect = e-110, Method: Composition-based stats. Identities = 185/334 (55%), Positives = 224/334 (67%), Gaps = 2/334 (0%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 M Y +R +F L+PE AH F + + P + + MGLTF NP+GL Sbjct: 1 MLYSLLRPLVFALEPETAHGIAFNAMETAHRLGLYR--ARPAPCRSRSIMGLTFPNPVGL 58 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAGLDK+GE IDAL A+GFG IEIGTVTPRPQPGN KPRLFRL A +INRMGFNN G+ Sbjct: 59 AAGLDKNGEHIDALAALGFGFIEIGTVTPRPQPGNPKPRLFRLPQANSIINRMGFNNNGI 118 Query: 121 DNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPG 180 + LV NVK Y G+LGINIGKN DTPVE+ DDYLIC+ K Y YA YI +NISSPNTP Sbjct: 119 EGLVANVKAMDYKGILGINIGKNFDTPVEKAVDDYLICLRKAYRYASYITVNISSPNTPN 178 Query: 181 LRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNID 240 LR LQ LD LL +K Q L H KY P+ VKIAPDL E+ +A L++H +D Sbjct: 179 LRQLQQATELDSLLGTLKLNQQRLADEHGKYTPLLVKIAPDLELPEIDSIAALLMKHRVD 238 Query: 241 GVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDS 300 GVIATNTTL R+ V+ + + + GGLSG PL ++T ++ RL L G LPIIGVGGI Sbjct: 239 GVIATNTTLSRAGVETLPHAREAGGLSGAPLAKRATSVVARLHHALQGALPIIGVGGIMD 298 Query: 301 VIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVT 334 A EKIAAGASL+Q+YSG +++GP L+ EI Sbjct: 299 AAGATEKIAAGASLIQVYSGLVYRGPHLVGEIAQ 332 >UniRef50_B2UNA2 Dihydroorotate dehydrogenase n=8 Tax=Bacteria RepID=PYRD_AKKM8 Length = 348 Score = 391 bits (1005), Expect = e-107, Method: Composition-based stats. Identities = 165/336 (49%), Positives = 228/336 (67%), Gaps = 1/336 (0%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLA 61 Y + LFQ++PE AH+ T LR LV +VP+ PV +G+ F N +GLA Sbjct: 5 LYSAAKSVLFQMNPETAHKVTLWGLRLAEKMRVLPLVMGEVPSDPVEILGMKFPNRVGLA 64 Query: 62 AGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVD 121 AG+DK+ + + A G GFG +E+GT+TPRPQPGN+KPRLFRL+ + +INRMGFNN G+ Sbjct: 65 AGMDKEADTVSAFGQAGFGFVEVGTLTPRPQPGNEKPRLFRLIPQKAIINRMGFNNEGIA 124 Query: 122 NLVENVKKA-HYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPG 180 VEN++ A + GVLG+NIGKNK TP E DYL C+ + A YIAIN SSPNTPG Sbjct: 125 AGVENIRSATRFHGVLGVNIGKNKITPNEDAAQDYLTCLRAAWPVADYIAINFSSPNTPG 184 Query: 181 LRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNID 240 LR LQ E LL ++K++Q++L A ++VPI +K+APD+++E + +++ + +D Sbjct: 185 LRDLQAAEPAARLLASLKSEQSNLAAETGRHVPIFMKVAPDVTDEHIAELSRVFLDEGLD 244 Query: 241 GVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDS 300 G+IATNTTL R V+ ++ GGLSG PL +STE+I + EL GR+PIIGVGGI + Sbjct: 245 GLIATNTTLSRVGVEANPRHEEAGGLSGAPLTERSTEVIGAFASELKGRIPIIGVGGIMN 304 Query: 301 VIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + A KI AGASLVQ+Y+GF+++GP LI+E V + Sbjct: 305 GVDAVAKIKAGASLVQLYTGFVYRGPDLIRECVEAM 340 >UniRef50_A1WJ81 Dihydroorotate dehydrogenase n=250 Tax=Bacteria RepID=PYRD_VEREI Length = 360 Score = 388 bits (998), Expect = e-106, Method: Composition-based stats. Identities = 172/339 (50%), Positives = 218/339 (64%), Gaps = 5/339 (1%) Query: 3 YPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAA 62 Y R LF LD E AHE L R TP + + P+ GL F N +GLAA Sbjct: 6 YALTRPFLFGLDAEAAHELIIDLLARGQRTPLQWAWCNQTVDDPIELAGLRFPNRVGLAA 65 Query: 63 GLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDN 122 GLDK+ CIDALGAMGFG +E GTVTP+ QPGN +PR+FRL +A LINR+GFNN G+ Sbjct: 66 GLDKNARCIDALGAMGFGFVEAGTVTPQAQPGNPRPRMFRLPEARALINRLGFNNAGLQA 125 Query: 123 LVENVKKAHYDGV-----LGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPN 177 V N++++ LG+NIGKN TP+ Q DYL C+E +Y +A Y+A+NISSPN Sbjct: 126 FVHNLQQSRLRAAGSALRLGLNIGKNASTPMAQASSDYLACLEGVYPHADYVALNISSPN 185 Query: 178 TPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRH 237 T LRTLQ ALD LL AI ++ L A H + VP+ VKIAPDL E +L +A +L RH Sbjct: 186 TQNLRTLQGDAALDHLLGAIAERRATLAARHGRRVPVFVKIAPDLDEAQLSLMAATLQRH 245 Query: 238 NIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGG 297 IDGVIATNTT+DR++VQG ++ ++GGLSG P+ S ++I +L L PIIGVGG Sbjct: 246 GIDGVIATNTTIDRAVVQGQRHAQESGGLSGAPVLQASNQVIGQLRAALGKGFPIIGVGG 305 Query: 298 IDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 I S A KI AGA LVQIY+G I++GP L+ + I Sbjct: 306 IMSAEDAVSKIRAGADLVQIYTGLIYEGPALVVQAARAI 344 >UniRef50_C9YAQ9 Dihydroorotate dehydrogenase n=2 Tax=cellular organisms RepID=C9YAQ9_9BURK Length = 389 Score = 383 bits (985), Expect = e-105, Method: Composition-based stats. Identities = 165/343 (48%), Positives = 214/343 (62%), Gaps = 15/343 (4%) Query: 3 YPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAA 62 Y R+ LF LDPE AH+ T L G P + PV GL F N +G+AA Sbjct: 36 YALARRVLFNLDPEVAHDITMAGLAASQGNPLKLAYCNSRVDDPVTIAGLQFPNRVGMAA 95 Query: 63 GLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDN 122 GLDK+ CID LGAMGFG +E+GTVTP QPGN KPR+FRL +A LINR+GFNN G+D Sbjct: 96 GLDKNARCIDGLGAMGFGFVEVGTVTPLAQPGNPKPRMFRLPEANALINRLGFNNHGLDA 155 Query: 123 LVENVKKA------HYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSP 176 + NV+++ + +LG+NIGKN TP+E+ DDYLIC++ +Y +A YI +NISSP Sbjct: 156 FIANVQRSALRQSKNPSLLLGLNIGKNAATPIEKATDDYLICLDGVYPHADYITVNISSP 215 Query: 177 NTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVR 236 NT LR+LQ +ALD LL AI ++ L H + P+ +KIAPDL +++ +A +L R Sbjct: 216 NTKNLRSLQSDDALDALLGAIAERREQLAQKHGQRKPVFLKIAPDLEADQVAVIAATLKR 275 Query: 237 HNID---------GVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELN 287 + D GVI TNTTL R V+GM + ++ GGLSG P+ KS +I +L L Sbjct: 276 YGTDSSGKVNNAWGVIGTNTTLSRGAVKGMPHAEEMGGLSGAPVLEKSNAVIGQLRAALG 335 Query: 288 GRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIK 330 PIIGVGGI S A KI AGA VQIY+G I+ GP L+K Sbjct: 336 KDFPIIGVGGIMSAADAVSKIKAGADAVQIYTGLIYSGPQLVK 378 >UniRef50_P57443 Dihydroorotate dehydrogenase n=2 Tax=Proteobacteria RepID=PYRD_BUCAI Length = 337 Score = 376 bits (967), Expect = e-103, Method: Composition-based stats. Identities = 195/337 (57%), Positives = 249/337 (73%), Gaps = 1/337 (0%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVP-AKPVNCMGLTFKNPLG 59 M+Y F+RK LF L+PE+AH T + L F+ + + +K + CMGL F N LG Sbjct: 1 MFYYFIRKLLFLLEPEKAHFLTLKYLNIKNIQFFDFFFYKTIILSKKIKCMGLIFDNKLG 60 Query: 60 LAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLG 119 AAG+DK+GE IDAL +GFG IE+GTVTP PQ GN KPR+FR+V EG+INRMGFNNLG Sbjct: 61 TAAGIDKNGEYIDALSKLGFGFIEVGTVTPLPQVGNPKPRMFRIVSMEGIINRMGFNNLG 120 Query: 120 VDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTP 179 +DNL+ N+KK+++ G++G+NIGKNK T +E DDYLIC+EKIY YAGYIAINISSPNT Sbjct: 121 IDNLIRNIKKSNFKGIIGVNIGKNKSTSLENSVDDYLICIEKIYCYAGYIAINISSPNTT 180 Query: 180 GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNI 239 LR LQYG LL IK KQ +L + KYVPIA+KI+PDLS +EL+ ++ L+R+ I Sbjct: 181 NLRNLQYGILFKKLLYKIKKKQKELHKKYLKYVPIAIKISPDLSIKELVDISKQLIRYKI 240 Query: 240 DGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGID 299 D VIATNTTLD S + G+KN + GGLSG PLQ KST I LS L ++PIIGVGGI+ Sbjct: 241 DAVIATNTTLDHSSLFGLKNSSEQGGLSGLPLQKKSTNTISILSKSLQKKIPIIGVGGIN 300 Query: 300 SVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 S+ +A+EKI +GA+L+QIYSG ++ GP LIK+I+ HI Sbjct: 301 SINSAKEKIESGATLIQIYSGLVYHGPKLIKKIINHI 337 >UniRef50_A9CK85 Dihydroorotate dehydrogenase n=16 Tax=Alphaproteobacteria RepID=PYRD_AGRT5 Length = 363 Score = 376 bits (966), Expect = e-103, Method: Composition-based stats. Identities = 150/336 (44%), Positives = 204/336 (60%), Gaps = 5/336 (1%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 ++ RK LF +DPE+AH + L+ + P GL F NPLG+ Sbjct: 4 LFSSVGRKGLFLIDPEKAHGLSVAALK---SGFLPTCMVPHDPRLQQTVAGLVFPNPLGM 60 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAG DK+ E L +GFG EIGTVTPR Q GN KPR+FRLV+ EG+INR+GFNN G Sbjct: 61 AAGYDKNAEVPGPLLRLGFGFTEIGTVTPRAQSGNPKPRIFRLVEDEGVINRLGFNNEGH 120 Query: 121 DNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPG 180 +E + +A G++G+NIG NKD+ E DY+ +E YA A Y +NISSPNTPG Sbjct: 121 AAALERLTQARLRGIVGVNIGANKDS--EDRIADYVQGIEAFYAVASYFTVNISSPNTPG 178 Query: 181 LRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNID 240 LR LQ E+L LLTA+ ++ K +PI +KIAPDL+EE L VA+ + H++D Sbjct: 179 LRDLQARESLAALLTAVLERRKTEAERLGKRIPIFLKIAPDLTEEGLDDVAEEALAHDLD 238 Query: 241 GVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDS 300 G+I +NTTL R ++ + + GGLSG+PL ST ++ ++ + LPIIGVGG+ S Sbjct: 239 GLIVSNTTLSREGLRPGPHRGEAGGLSGKPLFELSTTVLAKMRRRVGANLPIIGVGGVSS 298 Query: 301 VIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 A EK+ AGA LVQ+YS +++GP L IV + Sbjct: 299 AETALEKVRAGADLVQLYSCMVYEGPGLPSAIVKGM 334 >UniRef50_A5EV79 Dihydroorotate dehydrogenase n=3 Tax=Gammaproteobacteria RepID=PYRD_DICNV Length = 337 Score = 374 bits (962), Expect = e-102, Method: Composition-based stats. Identities = 167/334 (50%), Positives = 212/334 (63%), Gaps = 8/334 (2%) Query: 3 YPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAA 62 YP +R LF L+PE AH T Q L R + + P++ +G TF N LGLAA Sbjct: 4 YPHLRPLLFCLNPEIAHNLTLQILSRAAV-----FIPRIKAGNPIHLLGHTFPNRLGLAA 58 Query: 63 GLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDN 122 GLDK+ I A +GFG IE+GT TPRPQ GN KPRLFRL + + +IN MGFNN GV Sbjct: 59 GLDKNAVAISAFDRLGFGFIEVGTATPRPQSGNPKPRLFRLPEHQAIINCMGFNNDGVVA 118 Query: 123 LVENVK--KAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPG 180 L + V K ++GINIGKNK TP E+ DDYLI M Y YA Y+AINISSPNT G Sbjct: 119 LCQQVAAVKKRTRALIGINIGKNKLTPNERAADDYLIAMSTAYPYADYLAINISSPNTVG 178 Query: 181 LRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNID 240 LR LQ+G AL +LL +K +++ L A++ K VP+ VKIAPD E+L ++ + ID Sbjct: 179 LRDLQHGAALCELLQRLKTERDKLSAVYEKTVPLLVKIAPDNEREQLDEMLSIIEDSGID 238 Query: 241 GVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDS 300 G+IATNTTLD++ V G + D+ GGLSG+PL KST+II + L LP+I GG+ S Sbjct: 239 GIIATNTTLDKTAVTGHRYADEQGGLSGKPLTEKSTKIIAHIRERL-PDLPLIASGGVMS 297 Query: 301 VIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVT 334 K+ AGA LVQIYSG I+ GP LIK+ + Sbjct: 298 ADDYYAKLEAGADLVQIYSGLIYHGPQLIKDCLR 331 >UniRef50_A6H0L5 Dihydroorotate dehydrogenase n=28 Tax=Bacteria RepID=PYRD_FLAPJ Length = 350 Score = 374 bits (961), Expect = e-102, Method: Composition-based stats. Identities = 166/347 (47%), Positives = 210/347 (60%), Gaps = 13/347 (3%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTP-----FEALVRQKVPAKPVNCMGLTFK 55 MY +R LF DPE+ H FTF +R I P F++L GL FK Sbjct: 1 MYKLIIRPILFCFDPEKVHYFTFSLIRTIAKIPGFTSIFKSLYEVNDKRLEREVFGLKFK 60 Query: 56 NPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGF 115 NP+GLAAG DKD + L GFG IEIGT+TP+ Q GN K RLFRL + +INRMGF Sbjct: 61 NPVGLAAGFDKDAKLYKELSNFGFGFIEIGTLTPKGQEGNPKKRLFRLQEDSAIINRMGF 120 Query: 116 NNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISS 175 NN GV VE +KK + ++G NIGKNK TP E DY IC + +Y Y Y +N+SS Sbjct: 121 NNGGVLEAVERLKKNN-GVLIGGNIGKNKLTPNENATSDYEICFDALYDYVDYFVVNVSS 179 Query: 176 PNTPGLRTLQYGEALDDLLTAIKNKQNDLQ------AMHHKYVPIAVKIAPDLSEEELIQ 229 PNTP LR LQ E L LL ++NK + Q A PI +KIAPDL+ E+L+ Sbjct: 180 PNTPNLRELQEKEPLTQLLNTLQNKNQNKQKQTRDGAQSSGAKPILLKIAPDLTNEQLLD 239 Query: 230 VADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGR 289 + D + I G+IATNTT+ R +Q + N + GGLSG+PL +STE+IR LS + N Sbjct: 240 IIDIVKTTKIAGIIATNTTISREGLQSI-NRIEMGGLSGKPLTNRSTEVIRFLSQKSNKA 298 Query: 290 LPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 PIIGVGGI V A EK+ AGASL+Q+Y+GFI++GP L+K I I Sbjct: 299 FPIIGVGGIHCVQDAIEKLEAGASLIQLYTGFIYEGPALVKAINKEI 345 >UniRef50_Q3IU78 Dihydroorotate dehydrogenase n=13 Tax=cellular organisms RepID=PYRD_NATPD Length = 350 Score = 372 bits (956), Expect = e-102, Method: Composition-based stats. Identities = 136/339 (40%), Positives = 197/339 (58%), Gaps = 15/339 (4%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQK----VPAKPVNCMGLTFKNP 57 Y ++ ALFQLD E AH + L I GTP E +V P V+ G TF NP Sbjct: 3 LYQLLKPALFQLDAETAHGLGHRVLDGIQGTPLERIVADYCTVVDPRLRVDAFGQTFPNP 62 Query: 58 LGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNN 117 +G+AAG DK+ E DALGA+GFG +E+G VT PQ GN +PR+FRL + LINRMGFNN Sbjct: 63 VGVAAGFDKNAEIPDALGALGFGHVEVGGVTAEPQAGNPRPRMFRLAEDRALINRMGFNN 122 Query: 118 LGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPN 177 G D + E + +G+NIGK+K + + DY E++ Y +N+SSPN Sbjct: 123 DGADIVGERLAATDCRVPVGVNIGKSKSAANDDAEADYQYTYERVADGGDYFVVNVSSPN 182 Query: 178 TPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRH 237 TPGLR LQ + L+ +L +++ P+ VK++PDL++ + + + Sbjct: 183 TPGLRELQSRDRLESILGTLQD---------DGASPLLVKLSPDLTDAAIEDAIEVVEDL 233 Query: 238 NIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGG 297 +DG+IATNTT R D+ GGLSG P+ +ST+I+R ++ + PI+GVGG Sbjct: 234 GLDGIIATNTTTKRPASLHSDAADEEGGLSGAPITDESTDIVRFIAKRTDK--PIVGVGG 291 Query: 298 IDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 ID +A EKI GAS+VQ+Y+G +++GP + ++I + Sbjct: 292 IDDAESAYEKIRNGASVVQLYTGLVYEGPTIARDINRGL 330 >UniRef50_A1WTJ3 Dihydroorotate dehydrogenase n=1 Tax=Halorhodospira halophila SL1 RepID=PYRD_HALHL Length = 342 Score = 371 bits (954), Expect = e-101, Method: Composition-based stats. Identities = 149/333 (44%), Positives = 215/333 (64%), Gaps = 1/333 (0%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLA 61 Y +R+ LF+L+PE+AH + Q R VR +PA P MG+ F NP+GLA Sbjct: 1 MYALIRQLLFRLEPEQAHRVSMQLARLGLRIAAVPGVR-SLPAVPRRVMGIDFPNPVGLA 59 Query: 62 AGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVD 121 AG DKDGE +D L +GFG +E+GTVTPR QPGN +PR+FR+ + E LINRMGFNN G + Sbjct: 60 AGFDKDGEYMDVLEQLGFGFLELGTVTPRAQPGNPQPRVFRIPEHEALINRMGFNNQGAE 119 Query: 122 NLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGL 181 LV ++ + + GV+GINIGKN+DTP E+ +DY + +Y A Y+A+N+SSPNTPGL Sbjct: 120 PLVRRLEVSRHRGVVGINIGKNRDTPPERAVEDYAQALGMVYGVADYVAVNLSSPNTPGL 179 Query: 182 RTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDG 241 R LQ+ AL +L+ ++ ++ L +H K VP+ VKIAPD EL D L+ +DG Sbjct: 180 RDLQHEGALRNLIDRLQTERKRLAELHDKRVPLVVKIAPDWEAGELDATLDILLERRVDG 239 Query: 242 VIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSV 301 ++ATNTTL R+ V+ ++GGLSG PL+ ++ ++ +++ + R +I GGI S Sbjct: 240 IVATNTTLGRTGVEQTPQARESGGLSGAPLREQAEWVLEQVAARRDRRTALIAAGGIMSG 299 Query: 302 IAAREKIAAGASLVQIYSGFIFKGPPLIKEIVT 334 ++ GA LVQ+Y+G I++GP L++E V Sbjct: 300 EDVTRRLDLGADLVQLYTGMIYRGPGLVQEAVR 332 >UniRef50_Q7PYN9 AGAP002037-PA (Fragment) n=10 Tax=cellular organisms RepID=Q7PYN9_ANOGA Length = 404 Score = 371 bits (953), Expect = e-101, Method: Composition-based stats. Identities = 138/343 (40%), Positives = 196/343 (57%), Gaps = 16/343 (4%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLA 61 Y + + PE AH+ ++ P Q +G+ F NP+G+A Sbjct: 45 YNNVFMPIVRLIPPETAHDLAVLGVKWKLFRPPY----QDTDRLRTRLLGMAFSNPIGIA 100 Query: 62 AGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVD 121 AG DK GE + L +GFG +EIG+VTP PQPGN +PR+FRL + + ++NR GFN+ G D Sbjct: 101 AGFDKHGEAVQGLQLIGFGFVEIGSVTPEPQPGNARPRIFRLNEDKAIVNRYGFNSEGHD 160 Query: 122 NLVENVKKAHYDGV------LGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISS 175 + E +++ LGIN+GKNK + DY+ +++ A Y+ IN+SS Sbjct: 161 VVYERLRECREQQPPDQRVALGINLGKNKLSL--DAIADYVQGVKRFGTLADYLVINVSS 218 Query: 176 PNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADS-- 233 PNTPGLRT+Q L LLT + + L A + PI +K+APDLSEE+L ++ D Sbjct: 219 PNTPGLRTMQSKSTLQTLLTEVLKARASLPANEQR--PILLKLAPDLSEEDLREIVDVVR 276 Query: 234 LVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPII 293 +DG+I +NTT+DR N Q GGLSG PL+ +ST +I R+ G++PII Sbjct: 277 AKACAVDGLIVSNTTIDRPATLRSVNAGQLGGLSGPPLKHRSTAMIARVYKLTEGKIPII 336 Query: 294 GVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 GVGGI + A EKI AGAS VQ+Y+ FIF GPP++ +I + Sbjct: 337 GVGGIFTGEDAFEKIEAGASAVQLYTSFIFHGPPVVPKIKREL 379 >UniRef50_Q5PR57 Dihydroorotate dehydrogenase n=20 Tax=cellular organisms RepID=Q5PR57_DANRE Length = 407 Score = 370 bits (950), Expect = e-101, Method: Composition-based stats. Identities = 134/345 (38%), Positives = 202/345 (58%), Gaps = 18/345 (5%) Query: 2 YYPFVRKALFQ-LDPERAHEFTFQQLRRITGTPFEALVRQKVP-AKPVNCMGLTFKNPLG 59 Y + L + + E AH + + G K P + V+ MG F+NP+G Sbjct: 36 YASALMPVLQRFVGGETAHLMAVRLI----GLGLVPRNNYKDPTSLEVHVMGRKFQNPVG 91 Query: 60 LAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLG 119 +AAG DK GE +D L +GFG +E+GTVTP+PQ GN KPR+FRL + +INR GFN+ G Sbjct: 92 MAAGFDKHGEAVDGLYRLGFGFVEVGTVTPKPQDGNPKPRVFRLESDQAVINRYGFNSCG 151 Query: 120 VDNLVENVKKAHY--------DGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAI 171 + + E +K + LGIN+GKNK +P DY+ + + A Y+ + Sbjct: 152 LSAVHERLKAREHVQSELTKAGKPLGINLGKNKLSP--DAVSDYVEGVRTLGPLADYLVV 209 Query: 172 NISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVA 231 N+SSPNTPGLR LQ E L LL + +++ L+ + P+ VKIAPDL+ ++ +A Sbjct: 210 NVSSPNTPGLRDLQGKEELRHLLDKVVKERDSLRIEN--RPPVLVKIAPDLTTQDKQDIA 267 Query: 232 DSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLP 291 + ++ +DGV+ +NTT+ R N +TGGLSG+PL+ ST+ +R + G+LP Sbjct: 268 EVIMEVGVDGVMVSNTTVSRPDTLKDPNRVETGGLSGQPLKELSTQTVREMYTLTQGKLP 327 Query: 292 IIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 I+GVGG+ S A +KI AGASLVQ+Y+ +++GPP++ +I + Sbjct: 328 IVGVGGVASGQDAMDKIRAGASLVQLYTALVYQGPPVVNKIKREL 372 >UniRef50_P32748 Dihydroorotate dehydrogenase, mitochondrial n=14 Tax=Drosophila RepID=PYRD_DROME Length = 405 Score = 369 bits (949), Expect = e-101, Method: Composition-based stats. Identities = 128/342 (37%), Positives = 204/342 (59%), Gaps = 13/342 (3%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 ++ FV A+ L E +H+ + P + + G NP+G+ Sbjct: 45 LFRTFVMPAVRLLPAEASHQLAVLACK-YRLCPVSQYHDDQN--LHTSFFGRMLSNPIGI 101 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAG DK+ E +D L +GFG IE+GTVTP Q GN KPR+FRL + + +INR GFN+ G Sbjct: 102 AAGFDKNAEAVDGLQDLGFGFIEVGTVTPAAQEGNPKPRVFRLTEDKAIINRYGFNSDGH 161 Query: 121 DNLVENVK----KAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSP 176 +++ ++ K +++GV+G+N+G+NK T DY+ + A Y+ IN+SSP Sbjct: 162 QAVLQRLRLLRKKENFNGVVGVNLGRNKTTM--SPIADYVQGVRVFGPVADYLVINVSSP 219 Query: 177 NTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLV- 235 NT GLR +Q E L +LL + + ++ L +K VPI +K++PDLS +++ + + Sbjct: 220 NTKGLRDMQSKEKLRELLEQVNDTKSSLDK--NKNVPILLKLSPDLSLDDMKDIVWVIKR 277 Query: 236 -RHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIG 294 + +DG+I +NTT+ R ++ K ++TGGLSG PL+ +STE+I ++ +G++PIIG Sbjct: 278 KKSRVDGLIVSNTTVSRENIEKNKLAEETGGLSGPPLKARSTEMIAQMYQLTDGKIPIIG 337 Query: 295 VGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 VGG+ S A EKI AGAS VQIY+ +++GP L+++I + Sbjct: 338 VGGVASGYDAYEKIEAGASYVQIYTALVYEGPALVEDIKAEL 379 >UniRef50_A7NLW9 Dihydroorotate dehydrogenase n=18 Tax=Bacteria RepID=PYRD_ROSCS Length = 367 Score = 369 bits (947), Expect = e-100, Method: Composition-based stats. Identities = 140/342 (40%), Positives = 203/342 (59%), Gaps = 11/342 (3%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPF-----EALVRQKVPAKPVNCMGLTFK 55 M Y +R LF+LD ERAH+ R + P AL PA V GL F Sbjct: 1 MLYHLIRPLLFRLDAERAHDVVTAMFRATSRMPLLPRLISALYAWDDPALMVEWAGLRFA 60 Query: 56 NPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGF 115 +PLG+AAG DK + +DAL +GF +E+GTVTPRPQPGN PRLFRL + LINR+GF Sbjct: 61 SPLGVAAGFDKRADLVDALALLGFSHVEVGTVTPRPQPGNPGPRLFRLPEDMALINRLGF 120 Query: 116 NNLGVDNLVENVK-KAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINIS 174 N+ G+ + + ++ + ++G+NIGKN+DTP+E+ +DY + A Y+A+NIS Sbjct: 121 NSHGMVAVAKALRARRSRRVIVGVNIGKNRDTPLERAVEDYAATFVALAPLADYVAVNIS 180 Query: 175 SPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSL 234 SPNTPGLR L AL++LL + + L PIA+KI+PD + +++ +V + Sbjct: 181 SPNTPGLRRLHERAALEELLRELMRLNHGL----LYPRPIALKISPDETLDQIEEVVRAG 236 Query: 235 VRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIG 294 + IATNTTL R ++ + ++TGGLSGRPL ++ ++IR + G P+IG Sbjct: 237 CEAGVAAFIATNTTLAREGLRS-RLANETGGLSGRPLAPRARQVIRAIYRLTRGTPPVIG 295 Query: 295 VGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 VGG+ + A I AGA LVQ+Y+G ++ GP + +EI + Sbjct: 296 VGGVLTADDAYAHIRAGARLVQLYTGMVYAGPAIAREIKRGL 337 >UniRef50_C2QE06 Dihydroorotate dehydrogenase n=3 Tax=Bacillus cereus RepID=C2QE06_BACCE Length = 350 Score = 368 bits (945), Expect = e-100, Method: Composition-based stats. Identities = 148/330 (44%), Positives = 202/330 (61%), Gaps = 7/330 (2%) Query: 13 LDPERAHEFTFQQLRRITGTPFEALV-----RQKVPAKPVNCMGLTFKNPLGLAAGLDKD 67 +DPE+AH T L+ + F + R + + F NP+GLAAG DK Sbjct: 1 MDPEKAHTRTIHALKMMQSFSFARNMYNKNMRLNDSRLECKLLDIKFPNPIGLAAGFDKF 60 Query: 68 GECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVEN- 126 + L ++GFGS+E+G++TP+PQ GN KPRL+RL + LINRMGFN+ G+D +N Sbjct: 61 ADVYPGLASLGFGSVEVGSITPKPQSGNPKPRLYRLPEDTALINRMGFNSEGLDRAKQNF 120 Query: 127 VKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQY 186 + + LGIN+GKNKDTP DY +E +Y+Y Y INISSPNT GLR LQY Sbjct: 121 MTLPRPNIPLGINLGKNKDTPNSDATLDYQKGLETLYSYGDYFVINISSPNTEGLRDLQY 180 Query: 187 GEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATN 246 + L LL +I +K+N+L H++Y PI +KIAPDL+ E+L V + ID VIA N Sbjct: 181 VDTLKPLLASILDKRNELCKKHNQYRPIILKIAPDLTPEQLEGVISIIQEVKIDAVIAAN 240 Query: 247 TTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAARE 306 TT+ R+ + K Q GGLSG+PL +STEII ++ + G LPIIG GG+ + A E Sbjct: 241 TTISRTNLNS-KFQKQNGGLSGKPLNHRSTEIISKIYRQTQGNLPIIGSGGVFTGEDAYE 299 Query: 307 KIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 KI +GASL+QIY+ I++GP + K I I Sbjct: 300 KIKSGASLIQIYTSMIYRGPSVAKHINQEI 329 >UniRef50_A9WDI1 Dihydroorotate dehydrogenase n=13 Tax=Bacteria RepID=PYRD_CHLAA Length = 363 Score = 368 bits (945), Expect = e-100, Method: Composition-based stats. Identities = 149/349 (42%), Positives = 206/349 (59%), Gaps = 13/349 (3%) Query: 1 MYYPF-VRKALFQL---DPERAHEFTFQQLRRITGTPFEA-----LVRQKVPAKPVNCMG 51 ++Y + +R LF+L D E AHE T L I+ + L + G Sbjct: 7 LFYRYGIRPILFRLGRGDAETAHERTLHILALISRSRLLCKTIGYLTTIRDQRLQRTVCG 66 Query: 52 LTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLIN 111 + F NP+GLAAG+DKDG I A A+GFG +E+GTVT PQPGN +PRLFRL + E LIN Sbjct: 67 IPFPNPVGLAAGMDKDGVAIPAWAALGFGFVEVGTVTHHPQPGNPRPRLFRLPEQEALIN 126 Query: 112 RMGFNNLGVDNLVENVKK-AHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIA 170 RMGFNN G +L + + +G++IGK+K TP+EQ DDY +++ YA YIA Sbjct: 127 RMGFNNQGAASLARRLARLQPAPIPVGVSIGKSKITPLEQAIDDYRASFRQLFPYAAYIA 186 Query: 171 INISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYV-PIAVKIAPDLSEEELIQ 229 IN+SSPNTPGLR LQ + L LL A+++ +L + P+ VKIAPDLS+ + + Sbjct: 187 INVSSPNTPGLRQLQDADQLRALLAALQHDNAELGRTDQRGPRPLLVKIAPDLSDTAIEE 246 Query: 230 VADSLVRHNIDGVIATNTTLDRSLVQG--MKNCDQTGGLSGRPLQLKSTEIIRRLSLELN 287 V H + G+IATNTT+ R + G + + GGLSGRPL ++ ++R ++ Sbjct: 247 VLTVCADHGVAGIIATNTTISREGLTGVDPRLAAEAGGLSGRPLIARALHVVRLIARLTG 306 Query: 288 GRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 RLPIIGVGGI + + AGASL+QIY+G ++ GP L + I I Sbjct: 307 NRLPIIGVGGIHTPDDGLRMLEAGASLIQIYTGLVYYGPLLPRRINRAI 355 >UniRef50_Q2RX27 Dihydroorotate dehydrogenase n=14 Tax=cellular organisms RepID=PYRD_RHORT Length = 367 Score = 368 bits (945), Expect = e-100, Method: Composition-based stats. Identities = 143/335 (42%), Positives = 192/335 (57%), Gaps = 7/335 (2%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLA 61 +Y + LDPERAH + L A P + G F NPLGLA Sbjct: 4 WYRLAWPLICGLDPERAHHLAIRALALGLAGHDRA---ADDPVLACSLWGRRFANPLGLA 60 Query: 62 AGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVD 121 AG DK+GE DAL +GFG +E+GTVTPRPQ GN +PRLFRL +INRMGFNN G++ Sbjct: 61 AGFDKNGEVADALFDLGFGFVEVGTVTPRPQAGNPRPRLFRLTQDRAVINRMGFNNQGME 120 Query: 122 NLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGL 181 + +A GVLGIN+GKNK T E DY + K+ A Y+ IN+SSPNTPGL Sbjct: 121 AMAARFVRARPRGVLGINLGKNKTT--EDAAGDYEAGIAKLAPLADYLVINVSSPNTPGL 178 Query: 182 RTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDG 241 R LQ E L L+ + A P+ +K+APDL++E++ +A+ + +DG Sbjct: 179 RALQGREPLSLLIAR--ARAALDAACPGLRPPLLLKVAPDLTDEDMADIAEVALGGGLDG 236 Query: 242 VIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSV 301 +I TNTT+ R + +TGGLSG PL+ ++ ++I RL G LP+IGVGGI Sbjct: 237 LICTNTTIARPKSLVSDHAGETGGLSGLPLRYRARQVIARLYGLTKGALPLIGVGGIGDG 296 Query: 302 IAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 A +I AGASL+QIYS +++GP L+ I + Sbjct: 297 AEAYARIRAGASLIQIYSALVYEGPGLVGRIKRDL 331 >UniRef50_B0W4C3 Dihydroorotate dehydrogenase, mitochondrial n=2 Tax=Culicini RepID=B0W4C3_CULQU Length = 397 Score = 366 bits (941), Expect = e-100, Method: Composition-based stats. Identities = 141/341 (41%), Positives = 193/341 (56%), Gaps = 14/341 (4%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLA 61 Y + + PE AH L+ P Q + T +NP+G+A Sbjct: 41 YENIFMPMVRMVPPELAHRLAVLGLKMEVVRPSF----QDPEVLRTQLLNKTLENPVGIA 96 Query: 62 AGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVD 121 AG DK GE + L +GFG +EIG+VTP PQPGN KPR+FRL + + ++NR GFN+ G + Sbjct: 97 AGFDKHGEAVKGLERLGFGFVEIGSVTPEPQPGNPKPRVFRLNEDKAIVNRYGFNSEGHE 156 Query: 122 NLVENVKKAHYDG----VLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPN 177 + E +KK DG LGIN+G+NK + E +DY+ + K A Y+ +NISSPN Sbjct: 157 VVFERIKKLRQDGDLKVTLGINLGRNKKS--EDNIEDYVQGIRKFSVLADYLVVNISSPN 214 Query: 178 TPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSL--V 235 TPGLRT+Q L LLT I +N L + PI VKIAPDLS+ + ++ + Sbjct: 215 TPGLRTMQNKSTLQSLLTEIVKARNALPPNEQR--PILVKIAPDLSDGCVQEIIAVIQKK 272 Query: 236 RHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGV 295 IDG+I +NTT+DR N Q GGLSG PL KST+++ ++ GR+PIIGV Sbjct: 273 ECAIDGLIVSNTTIDRPSELKSINAGQLGGLSGAPLSSKSTQLVAKVYKWTGGRVPIIGV 332 Query: 296 GGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 GGI S A EKI AGAS VQ+Y+ I+ GPP++ + + Sbjct: 333 GGIFSGRDAYEKILAGASAVQLYTALIYHGPPIVARVKEEL 373 >UniRef50_D2S350 Dihydroorotate dehydrogenase n=2 Tax=Halobacteriaceae RepID=D2S350_9EURY Length = 356 Score = 366 bits (939), Expect = e-100, Method: Composition-based stats. Identities = 136/341 (39%), Positives = 199/341 (58%), Gaps = 14/341 (4%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGT-----PFEALVRQKVPAKPVNCMGLTFKN 56 Y VR F+L E AH+ + LR T A R PA V+ TF N Sbjct: 3 LYSRVRPLAFKLPAETAHDLGKRTLRAAQSTWPTRRALAAAYRYDHPALEVDLFDSTFPN 62 Query: 57 PLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFN 116 P+G+AAG DK+ E AL A+GFG +EIGTVTP PQ GND+PRLFRL + EG+INRMGFN Sbjct: 63 PVGIAAGFDKNAEVTHALEALGFGFVEIGTVTPYPQEGNDRPRLFRLREDEGMINRMGFN 122 Query: 117 NLGVDNLVENVKKAHYDG-VLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISS 175 G++ + E +++ G LG+NIGK + + +DY +++ +A Y+ +N+S Sbjct: 123 GQGMETVKERLEEDGTPGFPLGVNIGKMNSSTEREAIEDYRRVFDRVSPFADYVVVNVSC 182 Query: 176 PNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLV 235 PNTP E L + L+A + VP+ VKI PD E+ ++ + D + Sbjct: 183 PNTPDEFNEASPEHLRAIF-------ETLEAENDGNVPMLVKIGPDEPEDAILDLVDIVQ 235 Query: 236 RHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGV 295 +DG++ATNT+ R ++ ++ GGLSG P++ +ST++IR ++ +G LPI+GV Sbjct: 236 EFGLDGIVATNTSTAREGLES-PAREEWGGLSGAPIEDRSTDVIRTIAGHTDGELPIVGV 294 Query: 296 GGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 GG+DS +A EKI AGASLVQ+Y+GF+++GP I + Sbjct: 295 GGVDSAASAYEKIRAGASLVQLYTGFVYRGPSTAGRINQGL 335 >UniRef50_A5UX75 Dihydroorotate dehydrogenase n=1 Tax=Roseiflexus sp. RS-1 RepID=PYRD_ROSS1 Length = 361 Score = 364 bits (936), Expect = 2e-99, Method: Composition-based stats. Identities = 142/341 (41%), Positives = 201/341 (58%), Gaps = 11/341 (3%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGTPF-----EALVRQKVPAKPVNCMGLTFKN 56 Y +R LF+LD ERAH+ T + LR + P AL + P V+ GL F N Sbjct: 4 LYALIRPLLFRLDAERAHDLTAKALRVTSRAPLLPRLIRALYAWEDPLLAVDWSGLHFAN 63 Query: 57 PLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFN 116 P+G+AAG DK + +D L +GFG IE+GTVTPRPQPGN +PRLFRL + LINR+GFN Sbjct: 64 PVGVAAGFDKRADLVDGLALLGFGHIEVGTVTPRPQPGNPRPRLFRLPEDTALINRLGFN 123 Query: 117 NLGV-DNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISS 175 + G+ + D ++G+NIGKN+DTP+E+ +DY+ + A Y+A+NISS Sbjct: 124 SPGMVAVARALRARRSRDVIVGVNIGKNRDTPLERAVEDYVATFVALAPIADYVAVNISS 183 Query: 176 PNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLV 235 PNTPGLR L AL+ LL + L PIA+K++PD + ++L V + Sbjct: 184 PNTPGLRRLHERAALETLLHEL----TRLNRALPHPRPIALKVSPDETPDQLEAVVRAGC 239 Query: 236 RHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGV 295 I IATNTTL R + + +TGGLSGRPL ++ ++I + +G P+IGV Sbjct: 240 DAGIAAFIATNTTLARDDLHS-RLAIETGGLSGRPLTQRARQVIGAIYRLTHGAPPVIGV 298 Query: 296 GGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 GGI + A + I AGA L+QIY+G ++ GP + ++I + Sbjct: 299 GGIATAEDAYQHIRAGARLIQIYTGMVYAGPAIARDIKQGL 339 >UniRef50_Q02127 Dihydroorotate dehydrogenase, mitochondrial n=39 Tax=cellular organisms RepID=PYRD_HUMAN Length = 395 Score = 363 bits (933), Expect = 4e-99, Method: Composition-based stats. Identities = 131/332 (39%), Positives = 190/332 (57%), Gaps = 15/332 (4%) Query: 13 LDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDGECID 72 LDPE AH + + P + V +G F+NP+G+AAG DK GE +D Sbjct: 49 LDPESAHRLAVRF-TSLGLLPRARFQDSDM--LEVRVLGHKFRNPVGIAAGFDKHGEAVD 105 Query: 73 ALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKKAHY 132 L MGFG +EIG+VTP+PQ GN +PR+FRL + + +INR GFN+ G+ + ++ Sbjct: 106 GLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQ 165 Query: 133 DG--------VLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTL 184 LG+N+GKNK + +DY + + A Y+ +N+SSPNT GLR+L Sbjct: 166 KQAKLTEDGLPLGVNLGKNKTSV--DAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSL 223 Query: 185 QYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIA 244 Q L LLT + +++ L+ +H + VKIAPDL+ ++ +A + IDG+I Sbjct: 224 QGKAELRRLLTKVLQERDGLRRVHRPA--VLVKIAPDLTSQDKEDIASVVKELGIDGLIV 281 Query: 245 TNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAA 304 TNTT+ R +TGGLSG+PL+ ST+ IR + GR+PIIGVGG+ S A Sbjct: 282 TNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDA 341 Query: 305 REKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 EKI AGASLVQ+Y+ F GPP++ ++ + Sbjct: 342 LEKIRAGASLVQLYTALTFWGPPVVGKVKREL 373 >UniRef50_Q0J918 Os04g0676300 protein n=1 Tax=Oryza sativa Japonica Group RepID=Q0J918_ORYSJ Length = 601 Score = 358 bits (920), Expect = 1e-97, Method: Composition-based stats. Identities = 128/357 (35%), Positives = 188/357 (52%), Gaps = 31/357 (8%) Query: 4 PFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAAG 63 V LD E AH + R + G F NP+GLAAG Sbjct: 179 QLVNPLFALLDAEFAHRLAVTA---ASHGFVPREKRPDPSVLGLEIWGRKFTNPIGLAAG 235 Query: 64 LDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNL 123 DK+ E ++ L MGFG +E+G+VTP PQ GN KPR+FRL + +INR GFN+ G+ + Sbjct: 236 FDKNAEAVEGLLGMGFGFVEVGSVTPLPQEGNPKPRIFRLREHGAVINRCGFNSEGIVVV 295 Query: 124 VENVKKAH-------------------------YDGVLGINIGKNKDTPVEQGKDDYLIC 158 + + H G+LG+N+GKNK + E DY+ Sbjct: 296 AKRLGAQHGKRKMEETSSSTSPTTSDVKQGGKAGPGILGVNLGKNKIS--EDATADYVQG 353 Query: 159 MEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKI 218 + + YA Y+ IN+SSPNTPGLR LQ + L DL+ ++ ++++Q P+ VKI Sbjct: 354 VHTLSQYADYLVINVSSPNTPGLRKLQGRKQLKDLVKKVQAARDEMQWAEDGPPPLLVKI 413 Query: 219 APDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLV-QGMKNCDQTGGLSGRPLQLKSTE 277 APDLS+++L +A + +DG+I +NTT+ R + GGLSG+PL ST Sbjct: 414 APDLSKQDLEDIAAVALALRLDGLIISNTTISRPSPADTHPLAQEAGGLSGKPLFDLSTN 473 Query: 278 IIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVT 334 ++R + + G++P+IG GG+ S A +KI +GA+LVQ+Y+ F + GP LI I Sbjct: 474 VLREMYILTRGKIPLIGCGGVSSGEDAYKKIRSGATLVQLYTAFAYGGPALIPRIKK 530 >UniRef50_B4UG99 Dihydroorotate dehydrogenase n=23 Tax=Bacteria RepID=PYRD_ANASK Length = 364 Score = 358 bits (919), Expect = 2e-97, Method: Composition-based stats. Identities = 154/339 (45%), Positives = 201/339 (59%), Gaps = 7/339 (2%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 M +P +R LFQLDPER H L R+ A +PA V CMGL F P+GL Sbjct: 1 MLWPALRSVLFQLDPERVHHLAHWALHRVPLAVARARRPAPIPALAVRCMGLDFDGPVGL 60 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAG DK + L +GF +EIGT+TPRPQPGND+PRLFRL + L+NRMGFNN G+ Sbjct: 61 AAGFDKGDVALPGLFGLGFSHVEIGTITPRPQPGNDRPRLFRLPEHRALLNRMGFNNEGM 120 Query: 121 DNLVENVK---KAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPN 177 + + A G +GIN+GKNK TP E DYL C+E+++ YA Y+ +NISSPN Sbjct: 121 EACARRLAALPPAARLGPVGINVGKNKVTPNEDAAADYLACIERLHPYADYLVVNISSPN 180 Query: 178 TPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRH 237 TPGLR LQ +ALD LL A A P+ VK+APDLS E L + D + Sbjct: 181 TPGLRQLQERDALDRLLRACVRHL----AERAPGKPLLVKLAPDLSPEALDEAVDVAIAA 236 Query: 238 NIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGG 297 G++ATNTTL R+ V+ + GGLSG PL+ +T+++RR GR+PI+GVGG Sbjct: 237 GAAGIVATNTTLSRAGVERHPRAAEAGGLSGAPLERLATDVVRRCYARAAGRVPIVGVGG 296 Query: 298 IDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + A KI AGA+LVQ Y+G I+ GP + + + Sbjct: 297 VMDAEGAYAKIRAGATLVQAYTGLIYGGPGFVGRVNAGL 335 >UniRef50_Q056I9 Dihydroorotate dehydrogenase n=6 Tax=Leptospira RepID=Q056I9_LEPBL Length = 384 Score = 358 bits (918), Expect = 2e-97, Method: Composition-based stats. Identities = 143/340 (42%), Positives = 196/340 (57%), Gaps = 10/340 (2%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGTP-----FEALVRQKVPAKPVNCMGLTFKN 56 Y F++ LDPE +HE L P E++ + G+ F+N Sbjct: 21 YSTFLKPFFLSLDPETSHELAKNLLSISAKFPGILTLVESMTSYRSDRLKTRVAGIEFEN 80 Query: 57 PLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFN 116 PLG+ AG DK GE L MGFG IEIGT+T + QPGN KPR+FR + + LIN MGFN Sbjct: 81 PLGMGAGFDKTGELYPFLSRMGFGHIEIGTITGKSQPGNLKPRVFRYPEDQALINHMGFN 140 Query: 117 NLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSP 176 N G D+ + + GIN GK K E+ +DY+ ++K+ YA Y INISSP Sbjct: 141 NPGADSAERIIAPQKKRKIRGINAGKTKIISEEKAVEDYIYTLKKLSPYADYAVINISSP 200 Query: 177 NTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVR 236 NTPGLR Q + L+ IKN + +P+ VK APD+ ++L + +S + Sbjct: 201 NTPGLRDFQKQKNFVSLIQGIKNGLGK-----NFIIPLFVKFAPDMETKDLEALLESSLS 255 Query: 237 HNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVG 296 IDGV+ TNTT+D+S ++ N ++ GGLSG PL+ +STE +R L R+PIIGVG Sbjct: 256 LKIDGVVLTNTTIDKSSLKAYPNVEKEGGLSGVPLKNRSTEFVRVAYRILKRRIPIIGVG 315 Query: 297 GIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 GIDS AA EKI AGA L+QIY+G+I++GP L +I+ + Sbjct: 316 GIDSEKAALEKILAGADLIQIYTGYIYQGPFLPLKILEFL 355 >UniRef50_Q1V0W4 Dihydroorotate dehydrogenase n=5 Tax=Bacteria RepID=Q1V0W4_PELUB Length = 350 Score = 356 bits (915), Expect = 5e-97, Method: Composition-based stats. Identities = 137/336 (40%), Positives = 205/336 (61%), Gaps = 8/336 (2%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 M+ F R +F++DPE AH + L+ + P A + P N G NP+G+ Sbjct: 1 MFSKF-RSLIFKIDPETAHNLAIKSLK-LNILPNIADQNKGDPIFKTNLFGKNIDNPIGM 58 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAG DK+ E + L +GFG +E+GTVTP Q GN KPR+FRLV+ + LINR+GFNNLG Sbjct: 59 AAGFDKNAEVYNPLFKLGFGFVEVGTVTPLEQYGNPKPRVFRLVEDQALINRLGFNNLGA 118 Query: 121 DNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPG 180 +N+ ++ + G+LGINIG NKD+ E +DYLI + Y A YI +NISSPNT Sbjct: 119 ENISHRIRSNSHKGLLGINIGPNKDS--EDRLNDYLIGLRNFYDIADYITVNISSPNTEN 176 Query: 181 LRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNID 240 LR D+LL AI+ ++ L++ +PI VKI+PD+S+E++ ++ L++H + Sbjct: 177 LRAFHDETKFDELLNAIEKEKVKLKSK----IPIVVKISPDISDEQIELISKILIKHKVS 232 Query: 241 GVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDS 300 +I +NTT Q GGLSG+PL+ ++ ++I + L G++ IIGVGG+DS Sbjct: 233 AIIVSNTTAKNREKLNNILKHQKGGLSGKPLEEEANKLISKFYKLLKGKIEIIGVGGVDS 292 Query: 301 VIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 +A +K AGAS VQ+Y+G +F+GP ++ +I + Sbjct: 293 GESAYKKFQAGASYVQLYTGMVFQGPNIVGKIKKEL 328 >UniRef50_Q9RX14 Dihydroorotate dehydrogenase n=4 Tax=Bacteria RepID=PYRD_DEIRA Length = 369 Score = 355 bits (912), Expect = 1e-96, Method: Composition-based stats. Identities = 138/351 (39%), Positives = 195/351 (55%), Gaps = 17/351 (4%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKV----------PAKPVNCMG 51 Y VR LF+LD E AH T + L +G P + + + A G Sbjct: 1 MYQTVRPLLFRLDAEDAHHLTLRGLELASGVPLLPRLARTLTVPGTQGPGDAALRRTLWG 60 Query: 52 LT-----FKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDA 106 T F++PLGLAAGLDK+ + + A A GFG +E+GTVTP Q GN++PRLFRL + Sbjct: 61 QTPSEQTFESPLGLAAGLDKNAQAVPAFTAFGFGFVEVGTVTPLAQSGNERPRLFRLPED 120 Query: 107 EGLINRMGFNNLGVDNLVENVK-KAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAY 165 E LINRMGFNN G + + + +NIGKNK TP E +DY C+ + Sbjct: 121 EALINRMGFNNGGTAAMHARLAVLTDRAAPVWVNIGKNKVTPNEDAAEDYRKCVRALGDL 180 Query: 166 AGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEE 225 A +N+SSPNTPGLR LQ + L L+ A+ ++ + + P+ VK+APDL Sbjct: 181 ADAFVVNVSSPNTPGLRALQAADDLAALVRAVLDEVEAGRVRTLRRPPVLVKLAPDLHPA 240 Query: 226 ELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLE 285 + +++ G+I +NTTL R + N +Q GGLSGRPL +STE++R Sbjct: 241 DFEASVGAVLDAGASGLIISNTTLSRGGL-SHPNREQAGGLSGRPLTDRSTELVRDAYRL 299 Query: 286 LNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 G++PI+GVGG+ S A K+ AGA LV++YS I++GP L++EI + Sbjct: 300 TRGQVPIVGVGGVFSAEDAYAKLLAGADLVEVYSALIYRGPGLVREINAGL 350 >UniRef50_C6NV76 Dihydroorotate dehydrogenase n=1 Tax=Acidithiobacillus caldus ATCC 51756 RepID=C6NV76_9GAMM Length = 367 Score = 355 bits (911), Expect = 1e-96, Method: Composition-based stats. Identities = 136/337 (40%), Positives = 197/337 (58%), Gaps = 13/337 (3%) Query: 7 RKALFQLDPERAHEFTFQQLRRITGTP----FEALVRQKVPAKPVNCMGLTFKNPLGLAA 62 R LF L+PE AH + + L + P R P GL F +P+GLAA Sbjct: 9 RPWLFLLEPEHAHALSLRVLGGLNEMPKTRAHLWPHRPSDPRLAQELWGLHFAHPVGLAA 68 Query: 63 GLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDN 122 G DKDG+ + +L ++GF +E+GTVTPRPQPGN PR+FR +INR+GF + G Sbjct: 69 GFDKDGQALKSLASVGFAFLELGTVTPRPQPGNPGPRIFRYPQQRAVINRLGFPSQGGSA 128 Query: 123 LVENV-KKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGL 181 + + + LGINIGKN++TP+ DY ++++ +A YI+IN+SSPNTP L Sbjct: 129 VADRLAATLPLTVPLGINIGKNRETPLTAAVGDYRALIQQLGPFADYISINVSSPNTPEL 188 Query: 182 RTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHN--I 239 R LQ ++L LL ++ + LQ + P+ +KIAPDL+ +E+ +A + Sbjct: 189 RRLQDPQSLRPLLQELREARQKLQ----RQPPLLLKIAPDLAPDEVTALAALAQEPQPLL 244 Query: 240 DGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGID 299 DG IATNTTL R + + GGLSG PL+ ++ II +L +GRLPIIGVGG+ Sbjct: 245 DGFIATNTTLGRP--SDWPHPAEAGGLSGAPLKRRANGIIAQLYRASSGRLPIIGVGGVA 302 Query: 300 SVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + +KI AGASLVQ+Y+ I++GP L+++I + Sbjct: 303 TAQDVLDKIEAGASLVQLYTALIYEGPDLVQQITDAL 339 >UniRef50_Q2YWG7 Dihydroorotate dehydrogenase n=56 Tax=Staphylococcus RepID=Q2YWG7_STAAB Length = 354 Score = 355 bits (911), Expect = 1e-96, Method: Composition-based stats. Identities = 123/340 (36%), Positives = 187/340 (55%), Gaps = 11/340 (3%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGTPF-----EALVRQKVPAKPVNCMGLTFKN 56 Y ++ LF+++PE+AH T L+ + P + L K P G T+ N Sbjct: 1 MYKLIKPFLFKIEPEKAHGLTIDALKTLQKFPVLFPVVDKLFTYKNPTLSQTIQGNTYDN 60 Query: 57 PLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFN 116 P+GLAAG DK E AL +GFG++E+G +TP+PQPGN +PR+FRL++ + LINRMGFN Sbjct: 61 PIGLAAGFDKSCEVPKALEHLGFGALELGGITPKPQPGNPQPRMFRLLEDDALINRMGFN 120 Query: 117 NLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSP 176 N+G++ + +++K Y +GIN+G NK TP E DY+ ++ + +NISSP Sbjct: 121 NIGMNKALSHLRKNAYQVPVGINVGVNKMTPYEARYQDYIKVIDTFKHDVSFFTVNISSP 180 Query: 177 NTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVR 236 NT L+ + L A+ + H VPI +K+ D+ + L + ++ Sbjct: 181 NTENLQNFHDKDEFSMLCQAL----TTFKKQHDVTVPIYLKLTSDMDFDGLKALLPAITE 236 Query: 237 HNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVG 296 DG+I NTT R + N + GGLSGRPL ++ ++I+ + NG IIG G Sbjct: 237 T-FDGIILANTTRQRDGLTS-ANKVEEGGLSGRPLFERNLKLIKYAYQQTNGEFLIIGTG 294 Query: 297 GIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 G+ S A + + GASL+QIYS + +GP L K++ I Sbjct: 295 GVFSTEDAIKMMRHGASLIQIYSSLVIEGPGLTKKMNKGI 334 >UniRef50_B6BWI2 Dihydroorotate oxidase n=1 Tax=beta proteobacterium KB13 RepID=B6BWI2_9PROT Length = 335 Score = 354 bits (910), Expect = 2e-96, Method: Composition-based stats. Identities = 140/336 (41%), Positives = 203/336 (60%), Gaps = 2/336 (0%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 M Y R +F L PE +H F + L+ + V+ KP+ GL FKN +GL Sbjct: 1 MLYRLFRSVIFLLPPEFSHHFILKILKIVNFISLLK-VKDIKNEKPIFIKGLNFKNKVGL 59 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAG DK+ E + +GFG +E+GTVTP+PQ GN KPR+FR + LIN GFNN+G+ Sbjct: 60 AAGFDKNAEHMQIFENLGFGFLELGTVTPKPQSGNKKPRIFRDPKNDALINSFGFNNVGI 119 Query: 121 DNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPG 180 ++N+KK+ + V+GINIGKN TP E +DY+ CM + Y YA Y+ +NISSPNT Sbjct: 120 YKFIDNIKKSKINLVIGINIGKNALTPYEDSINDYIACMREAYVYADYLTVNISSPNTKN 179 Query: 181 LRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNID 240 LR L L + ++ ++N LQ K VPI +K++PD+ + ++ + D L+ +NID Sbjct: 180 LRDLHNLSDLSIFIKSLMIEKNKLQKKLKKSVPIFLKLSPDIEKSKIKPIIDLLIANNID 239 Query: 241 GVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDS 300 GVI TNTT+D+S + GG+SG PL++KS +++ + +L II VGGI + Sbjct: 240 GVIVTNTTIDKSKISK-PYQHLPGGVSGAPLKIKSEQMLSTVKKISKNKLLIISVGGIMT 298 Query: 301 VIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 A ++I GA LVQIY+G I++GP L+ EI + Sbjct: 299 ADDALKRIRMGADLVQIYTGLIYQGPSLVNEIRQKL 334 >UniRef50_B6R4R9 Dihydroorotate oxidase n=1 Tax=Pseudovibrio sp. JE062 RepID=B6R4R9_9RHOB Length = 367 Score = 354 bits (908), Expect = 3e-96, Method: Composition-based stats. Identities = 139/331 (41%), Positives = 205/331 (61%), Gaps = 7/331 (2%) Query: 8 KALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKD 67 +AL LDPE +H T + L + + A LTFKNP+G+AAG DK+ Sbjct: 13 RALHCLDPETSHNATIKMLASGLAP---TFGQVENKALEYKLGDLTFKNPVGMAAGFDKN 69 Query: 68 GECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENV 127 E I L +GFG +E+GTVTP PQ GN KPR FRL +INR GFNN G D + E + Sbjct: 70 AEAITPLMKLGFGHVEVGTVTPLPQEGNPKPRNFRLSADRAVINRYGFNNDGHDVVYERI 129 Query: 128 KKA-HYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQY 186 +KA GVLGIN+G NK + E DY++ +++ A Y+ NISSPNTPGLR LQ Sbjct: 130 RKAGRTPGVLGINVGANKLS--EDRVADYVLGVKRFAELADYLTANISSPNTPGLRDLQE 187 Query: 187 GEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATN 246 +AL LL+AI N +++ + + VP+ +KIAPD++EE L ++A+ ++ + +DG+I +N Sbjct: 188 KDALAHLLSAIVNARDEQEDRLGRKVPVMLKIAPDVTEEALKEIAEVVMTNKVDGMIVSN 247 Query: 247 TTLDR-SLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAR 305 TT+ R S ++ + ++ GGLSG PL ++T + + + LP+ GVGG+D+ A Sbjct: 248 TTIARPSTLKDQQQAEEAGGLSGAPLFERATIALAKTRRAVGPDLPLFGVGGVDTPEKAA 307 Query: 306 EKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 KI AGA+ +Q+YSG +++G L+K+I H+ Sbjct: 308 AKIFAGANQIQLYSGMVYEGQTLVKKINKHL 338 >UniRef50_B3CMR9 Dihydroorotate dehydrogenase n=10 Tax=Rickettsiales RepID=B3CMR9_WOLPP Length = 355 Score = 353 bits (906), Expect = 6e-96, Method: Composition-based stats. Identities = 127/336 (37%), Positives = 195/336 (58%), Gaps = 14/336 (4%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLA 61 Y +R LF L PE AH L+++ L + + VN G ++P+GLA Sbjct: 13 YKMILRNLLFLLPPEIAHSLVITALKKMPCRKPIELPK----SLNVNFFGNKIRSPVGLA 68 Query: 62 AGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVD 121 AG DK+ E + + + GFG IE GTVT PQ GN KPR+FRL+ EG+INR+GFNN GVD Sbjct: 69 AGFDKNAEVVKPMLSFGFGFIEAGTVTKHPQYGNKKPRIFRLIKDEGIINRLGFNNKGVD 128 Query: 122 NLVENVKKAHY-DGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPG 180 ++ + + + + GINIG+N + + DY+ ++ +Y + YI +NISSPNTP Sbjct: 129 YFLKQISETKLGNCIFGINIGRNSTS--KDQISDYVDLIKIVYGKSNYIVLNISSPNTPN 186 Query: 181 LRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNID 240 LR L + L LL +I + + + +PI +KI+PD+ ++ +A+ + + ID Sbjct: 187 LRDLHNKQELSKLLKSITLTRKSIDSSE--SIPIILKISPDIDQQTKENIAELTLEYKID 244 Query: 241 GVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDS 300 G+I +NTT+ R +++GGLSGRPL STE++ + R+ +IG GGI S Sbjct: 245 GLIVSNTTISRD-----SYYNESGGLSGRPLFQLSTELLSDMYKLTKSRILLIGCGGISS 299 Query: 301 VIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + A EKI AGASLVQ+Y+ +++G ++ +I + Sbjct: 300 GVDAYEKIKAGASLVQLYTALVYQGHQVVNKINLEL 335 >UniRef50_A5EA61 Dihydroorotate dehydrogenase n=122 Tax=cellular organisms RepID=PYRD_BRASB Length = 364 Score = 351 bits (902), Expect = 1e-95, Method: Composition-based stats. Identities = 138/337 (40%), Positives = 192/337 (56%), Gaps = 9/337 (2%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLA 61 + L LD E AH Q L+ + R V GL F NP+G+A Sbjct: 5 FDQLSLPLLRWLDAEDAHRLAIQGLKLLPAIKP----RPDDAKLAVRAFGLNFPNPVGMA 60 Query: 62 AGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVD 121 AG DK+ E DAL +GFG +EIG+VTPRPQ GN +PRLFRL E ++NRMGFNN G + Sbjct: 61 AGFDKNAEVPDALLRLGFGFVEIGSVTPRPQSGNPRPRLFRLERDEAVVNRMGFNNDGAE 120 Query: 122 NLVENVK-KAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPG 180 ++ + +A+ G++G+N+G NKD+ DY+ +E A Y +NISSPNTPG Sbjct: 121 IVLRRLAGRANQGGIVGVNVGANKDSA--DRVADYVRLIETFAPVASYFTVNISSPNTPG 178 Query: 181 LRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNID 240 LR LQ L++LL+ + ++ ++ P+ +KIAPDLS EL V +D Sbjct: 179 LRNLQQAAQLNELLSKVLEARDRVRRKAG-DTPVLLKIAPDLSLAELDDVVHVARSRGVD 237 Query: 241 GVIATNTTLDRSL-VQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGID 299 G+I +NTTL R ++ + GGLSGRPL ST ++ + + G P+IGVGGID Sbjct: 238 GMIVSNTTLARPNSLREQLRAKEQGGLSGRPLFRLSTRMVAETFVRVEGAFPLIGVGGID 297 Query: 300 SVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 S AA KI AGASL+Q+YS ++KG L++ I + Sbjct: 298 SGGAALTKIRAGASLIQLYSSLVYKGLGLVESIKADL 334 >UniRef50_B1ZSY3 Dihydroorotate oxidase n=3 Tax=Verrucomicrobia RepID=B1ZSY3_OPITP Length = 352 Score = 351 bits (902), Expect = 2e-95, Method: Composition-based stats. Identities = 145/336 (43%), Positives = 199/336 (59%), Gaps = 16/336 (4%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGT-PFEALVRQK-----VPAKPVNCMGLTFK 55 Y +R LF++DPE+AHE L + P L+ + +PV GL F Sbjct: 5 YERAIRPVLFRMDPEKAHELAVHGLTLLAKLQPVCRLLEWQHRLPADCRRPVRAFGLDFP 64 Query: 56 NPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGF 115 N +GLAAG DK+ AL A+GFG +EIGT+T QPGN+KPR+FR + +INRMGF Sbjct: 65 NAIGLAAGFDKNATAWPALAALGFGHVEIGTITALAQPGNEKPRVFRFPAEKAVINRMGF 124 Query: 116 NNLGVDNLVENVKKAH----YDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAI 171 NN G + + + LGIN+GK+K T ++Q DYL ++ +A YIA+ Sbjct: 125 NNEGSEAIARRLAHQPGVGQRRIPLGINLGKSKVTDLDQAAQDYLTSFGRLADHADYIAL 184 Query: 172 NISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVA 231 N+SSPNTPGLR LQ + +LL AI + VP+ +KIAPDL+ ++ V Sbjct: 185 NVSSPNTPGLRQLQDEARVRELLGAISAA----NRARPRPVPLLLKIAPDLTFPQIDAVL 240 Query: 232 DSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLP 291 +L+ DG+IATNTTL R +Q GGLSGRPL+ +STEII ++ G+LP Sbjct: 241 AALMEFRFDGIIATNTTLARPG--PFAAANQAGGLSGRPLRRRSTEIINYIARATAGKLP 298 Query: 292 IIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPP 327 IIGVGGI+ +A EK+ AGA+L+QIY+G I++GP Sbjct: 299 IIGVGGIEDGASAAEKLDAGATLLQIYTGMIYRGPW 334 >UniRef50_Q47RF2 Dihydroorotate dehydrogenase n=52 Tax=Bacteria RepID=PYRD_THEFY Length = 377 Score = 350 bits (898), Expect = 4e-95, Method: Composition-based stats. Identities = 140/349 (40%), Positives = 198/349 (56%), Gaps = 16/349 (4%) Query: 1 MYYPFV-RKALFQLDPERAHEFTFQQLRRITGTP-----FEALVRQKVPAKPVNCMGLTF 54 M Y F+ L ++D ERAH +F LR + P ++ + P V G F Sbjct: 1 MLYQFIFHTLLRRVDAERAHRVSFAGLRALAAVPGTTRLMRRVLGPREPELRVRVFGREF 60 Query: 55 KNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMG 114 PLGLAAG DK+ + AL A+GF +EIGTVT +PQPGN +PRLFRLV ++NRMG Sbjct: 61 PGPLGLAAGFDKNARGVAALTALGFSHVEIGTVTGQPQPGNPRPRLFRLVADRAIVNRMG 120 Query: 115 FNNLGVDNLVE----NVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIA 170 FNN G + E + + D ++G+NIGK K P DY+ + A Y+ Sbjct: 121 FNNEGSQAVSERLRAHRARRARDLIVGVNIGKTKVVPDSDAVADYVTSARRFADLADYLV 180 Query: 171 INISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQV 230 +N+SSPNTPGLR LQ E L LL+A++ ++ +P+ VKIAPDL++E++ V Sbjct: 181 VNVSSPNTPGLRDLQATERLRPLLSAVRRTLDE---AGRPDLPLLVKIAPDLADEDIDAV 237 Query: 231 ADSLVRHNIDGVIATNTTLDRSLVQGMK---NCDQTGGLSGRPLQLKSTEIIRRLSLELN 287 AD V +DG+IATNTT+ R + GGLSG PL+ ++ +++RRL + Sbjct: 238 ADLAVELGLDGIIATNTTVSRDGLATDPEEVAALGAGGLSGAPLKERALQVLRRLRARVG 297 Query: 288 GRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 RL +I VGGI++ A +I AGA+LVQ Y+G I+ GP + I + Sbjct: 298 DRLVLIAVGGIETPEDAWARIRAGATLVQGYTGLIYGGPLWPRRIHRGV 346 >UniRef50_Q5HL43 Dihydroorotate dehydrogenase n=8 Tax=Staphylococcus RepID=Q5HL43_STAEQ Length = 354 Score = 350 bits (898), Expect = 5e-95, Method: Composition-based stats. Identities = 125/340 (36%), Positives = 185/340 (54%), Gaps = 11/340 (3%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGTP-----FEALVRQKVPAKPVNCMGLTFKN 56 Y V+ LF+LDPERAH T L+ + L P + G++F N Sbjct: 1 MYKLVKPLLFKLDPERAHGLTINALKCVQKCSPILPIVNKLFTYNNPILTQHIHGISFDN 60 Query: 57 PLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFN 116 P+GLAAG DK E AL +GFG+IE+G +TP+PQPGN KPR++RL++ + LINRMGFN Sbjct: 61 PIGLAAGFDKSCEVPKALENIGFGAIELGGITPKPQPGNPKPRMYRLLEDDALINRMGFN 120 Query: 117 NLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSP 176 N G++ + N++ +G+N+G NK T E DY+ ++ + +NISSP Sbjct: 121 NKGMNKALSNLRNHSCSIPVGLNVGVNKTTSYENRYQDYIKVIDTFKNDVSFFTVNISSP 180 Query: 177 NTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVR 236 NT L+ + L A+ N +A ++ VPI +K+ D+ + ++ S+ Sbjct: 181 NTENLQNFHDEDEFSMLCDAL----NSFKAKNNINVPIFLKLTSDMELDGFKKILPSITD 236 Query: 237 HNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVG 296 DGV+ NTT R + KN Q GGLSGRPL ++ ++++ + G IIG G Sbjct: 237 T-FDGVMLANTTRQRDGLNS-KNKIQEGGLSGRPLFQRNLQLVKYAYQQTRGNFLIIGTG 294 Query: 297 GIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 GI S A + + GASL+QIYS + +GP L K++ I Sbjct: 295 GIFSSEDAIKMLRNGASLLQIYSSLVIEGPGLTKKMNKEI 334 >UniRef50_Q75XR0 Dihydroorotate dehydrogenase n=3 Tax=Eukaryota RepID=Q75XR0_EUGGR Length = 435 Score = 349 bits (897), Expect = 6e-95, Method: Composition-based stats. Identities = 132/344 (38%), Positives = 187/344 (54%), Gaps = 20/344 (5%) Query: 8 KALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKD 67 + L+ E AH+ + V + GL F NPLGLAAG DK Sbjct: 64 PLVRLLEAEAAHDCAIRAASWGL---VPRDVHPDPADLEMEVWGLKFSNPLGLAAGFDKH 120 Query: 68 GECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENV 127 GE +DAL GFG +EIGTVTP PQPGN PR+FRL +INR GFN+ G+ + + + Sbjct: 121 GEAVDALLGTGFGFVEIGTVTPLPQPGNPSPRMFRLEQDRAIINRYGFNSQGLAAVRKRL 180 Query: 128 -----KKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLR 182 + A G++G+N+GKNK E DY + ++ YA Y+ IN+SSPNTPGLR Sbjct: 181 EARQHRPAPRGGLVGVNVGKNKLQ--EDAAADYSKGLRELGPYADYLVINVSSPNTPGLR 238 Query: 183 TLQYGEALDDLLTAIKNKQNDLQA----------MHHKYVPIAVKIAPDLSEEELIQVAD 232 LQ A+ DL+ A ++++ +P+ +KIAPDL+ EE +A+ Sbjct: 239 NLQKRSAMADLIKASMVARDEVVRDADGRRAAAGKSAAPLPLLIKIAPDLTAEEKQDIAE 298 Query: 233 SLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPI 292 ++ IDG+I +NTT+ R + QTGGLSG PL+ ST+ IR + G +PI Sbjct: 299 VVMETKIDGLIVSNTTVSRPASLLSPHKGQTGGLSGAPLREMSTQAIRDMYALTRGTVPI 358 Query: 293 IGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 +GVGG+ + EK+ AGASLVQ+YS ++ GP + + Sbjct: 359 VGVGGVATGEDVLEKLKAGASLVQMYSMLVYDGPGAPPRVKKGL 402 >UniRef50_A8WW30 C. briggsae CBR-DHOD-1 protein n=3 Tax=Caenorhabditis RepID=A8WW30_CAEBR Length = 426 Score = 348 bits (894), Expect = 1e-94, Method: Composition-based stats. Identities = 140/360 (38%), Positives = 200/360 (55%), Gaps = 30/360 (8%) Query: 2 YYPFVRKALFQ-LDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 Y V + + +D E +H + + P R++ P G F+NP+GL Sbjct: 47 YKKAVMPMVHKFVDGEDSHRWAVRAASW-GLLPRFGWNRKEYPELKCELFGREFRNPIGL 105 Query: 61 AAGLDKDGECIDALGA-MGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLG 119 AAG DKDG+ I L GFG IEIG+VTP PQPGN++PR+FRL++ EG+INR GFN+ G Sbjct: 106 AAGFDKDGQAITQLAKNSGFGLIEIGSVTPIPQPGNNRPRVFRLLEDEGVINRYGFNSDG 165 Query: 120 VDNLVENVKKAHYDGVL------GINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINI 173 V + + V+ A V G+N+GKNK T E K DY I + + Y+ +N+ Sbjct: 166 VGRVHQRVRSARDAWVPEQYAYFGVNLGKNKLT--EDAKLDYEIGVNYFAPHCDYLVLNV 223 Query: 174 SSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADS 233 SSPNTPGLR++Q L+ LL +K + K I +KIAPDL + E+ +A Sbjct: 224 SSPNTPGLRSMQKKSDLEKLLAYVKESLD--MHKLEKRPQIFLKIAPDLIDSEMKDIAHV 281 Query: 234 L--VRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLP 291 + + +DG+I +NTT+ R +N +TGGLSG P++ STE IR++ NG++P Sbjct: 282 VTNKKFGVDGIIVSNTTIARPDYLKSENKAETGGLSGAPVREISTECIRKMYKLTNGQIP 341 Query: 292 IIGVGGIDSVIAAREKIA---------------AGASLVQIYSGFIFKGPPLIKEIVTHI 336 IIG GG+ S A EKI AG SLVQ+YS F+++G P+I +I + Sbjct: 342 IIGCGGVFSGEDAYEKIRYNRRNAIDSNYNIFSAGGSLVQLYSAFVYEGFPVIGKIKREL 401 >UniRef50_B0MVX7 Putative uncharacterized protein n=1 Tax=Alistipes putredinis DSM 17216 RepID=B0MVX7_9BACT Length = 356 Score = 348 bits (893), Expect = 2e-94, Method: Composition-based stats. Identities = 127/344 (36%), Positives = 189/344 (54%), Gaps = 12/344 (3%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTP-----FEALVRQKVPAKPVNCMGLTFK 55 MY ++ LF ++ ERAH LR I P A+ R + P+ GL F Sbjct: 1 MYRKLIKPILFAMNIERAHSTVLFLLRMIGKIPGGRALLRAMYRTEHPSLEREVFGLRFP 60 Query: 56 NPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGF 115 NP+GLAAG D++GE L A+GFG +EIGTVTP+PQ GN +PR+FRL +INR G Sbjct: 61 NPIGLAAGFDRNGEAFRELSALGFGFVEIGTVTPQPQAGNPRPRIFRLPADRAIINRSGL 120 Query: 116 NNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISS 175 NN G+ + ++ H ++G NIGKN T Q DYL +Y Y Y +IN+ Sbjct: 121 NNKGLYKAIAQLRHRHDRLIIGGNIGKNTLTQPSQVAADYLKMFRNLYQYVDYFSINVCC 180 Query: 176 PNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLV 235 N L ++L + D + ++Y PI +KI+PDL + + +V D ++ Sbjct: 181 DNCADGSVSHNKAHLMNILQPLF----DFRRGQNQYRPILLKISPDLPDPLIDEVTDLML 236 Query: 236 RHNIDGVIATNTTLDRSLVQGMKNC---DQTGGLSGRPLQLKSTEIIRRLSLELNGRLPI 292 +DG++A N T R ++ + +G LSG PL ++ E++RR+ +G PI Sbjct: 237 STPLDGIVAVNGTFSRKGLETDEETLDEIGSGRLSGAPLTQRAIEVVRRIHRRSHGAYPI 296 Query: 293 IGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 IGVGG+ + + +AAGASLVQ+Y+G+I++GP L+KEI + Sbjct: 297 IGVGGLMNARDVKAMLAAGASLVQLYTGYIYEGPSLVKEICRAL 340 >UniRef50_Q1GGD3 Dihydroorotate oxidase A n=18 Tax=Alphaproteobacteria RepID=Q1GGD3_SILST Length = 352 Score = 347 bits (890), Expect = 4e-94, Method: Composition-based stats. Identities = 134/333 (40%), Positives = 189/333 (56%), Gaps = 10/333 (3%) Query: 4 PFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAAG 63 + +LDPE AH + + LR + P + GL+ NP+GLAAG Sbjct: 6 KLALGLMHRLDPETAHGLSIKALRAGLTPRPGPVTS---PRLRTDVAGLSLPNPVGLAAG 62 Query: 64 LDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNL 123 DK+ E + L GFG IE+G TPRPQPGN KPRLFRL + INR GFNN G+D + Sbjct: 63 FDKNAEALAPLSEAGFGFIEVGAATPRPQPGNPKPRLFRLSEDRAAINRFGFNNEGMDTI 122 Query: 124 VENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRT 183 + + + GV+G+N+G NKD+ E D+ + A+ + +N+SSPNT LR Sbjct: 123 GKRLAQRPKSGVIGLNLGANKDS--EDRAQDFARVLSHCGAHLDFATVNVSSPNTEKLRD 180 Query: 184 LQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVI 243 LQ +AL LL + + + LQ + +P+ +KIAPDL L +A+ ID VI Sbjct: 181 LQGKDALASLLAGVIDAREALQ----RPIPVFLKIAPDLDISGLDDIAEVARDSGIDAVI 236 Query: 244 ATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIA 303 ATNTTL R ++ + D+ GGLSG PL +ST ++ +LS L+G +PIIGVGGI + Sbjct: 237 ATNTTLSRDGLKST-HRDEMGGLSGAPLFERSTRVLAQLSQRLDGAVPIIGVGGISTAEG 295 Query: 304 AREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 A KI AGAS VQ+Y+ ++ G L E+ + + Sbjct: 296 AYAKIRAGASAVQLYTALVYGGLSLASEVASGL 328 >UniRef50_C1EIH8 Dihydropryrimidine dehydrogenase n=1 Tax=Micromonas sp. RCC299 RepID=C1EIH8_9CHLO Length = 488 Score = 346 bits (889), Expect = 5e-94, Method: Composition-based stats. Identities = 140/375 (37%), Positives = 198/375 (52%), Gaps = 43/375 (11%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLA 61 + ++ A+ +DPE AH + L R P E R+ PA V+ GL F NP+GLA Sbjct: 92 LFEYLAPAMRLMDPETAHNVGIELLAR-GVAPVET--RRDPPALAVDAWGLRFANPIGLA 148 Query: 62 AGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVD 121 AG DKD + ALGAMGFG +EIG+VTP+PQPGN KPR+FRL + +INR GFN+ G + Sbjct: 149 AGFDKDAKAFPALGAMGFGFVEIGSVTPKPQPGNPKPRVFRLRELGAVINRYGFNSEGHE 208 Query: 122 NLVENV-------------------------------KKAHYDGVLGINIGKNKDTPVEQ 150 + + A +G+N+GKNK TP Sbjct: 209 PARARLEAYRADTRATQSEFDATPVTPVTPEGAGVPRRLAERGAPVGVNLGKNKLTPEAA 268 Query: 151 GKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQ----- 205 DDY + + + A YI +NISSPNTPGLR LQ L LL + +++ Sbjct: 269 AADDYALGVRALGHTADYIVVNISSPNTPGLRALQGKAHLKGLLRKVLAARDESALKSRT 328 Query: 206 ---AMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSL-VQGMKNCD 261 H P+ +KIAPDL++ ++ V + +DG+I +NTT+ R V Sbjct: 329 GGGQTHAHKPPVLLKIAPDLTDGDIKDVVAAATSCAVDGIIVSNTTIARPEDVAAHARGG 388 Query: 262 QTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGF 321 + GGLSG+PL STE++ R+ G++P++G GG+ S A EKI AGASLVQ+Y+ F Sbjct: 389 EAGGLSGKPLMDPSTEVLFRVYQLTGGKIPLVGCGGVASGRDAYEKIRAGASLVQMYTAF 448 Query: 322 IFKGPPLIKEIVTHI 336 + GP L+ + + Sbjct: 449 AYAGPALVPAMKAEL 463 >UniRef50_B0CUF5 Predicted protein n=4 Tax=Dikarya RepID=B0CUF5_LACBS Length = 499 Score = 345 bits (885), Expect = 2e-93, Method: Composition-based stats. Identities = 125/352 (35%), Positives = 188/352 (53%), Gaps = 20/352 (5%) Query: 1 MYYPFVRKAL-FQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLG 59 ++ L F LD E H+F + LR P + ++ G NP+G Sbjct: 67 LHRYIFTPILRFALDAETGHKFAVKVLRSGLA-PKDPVL--DDARLNCQIWGQEASNPVG 123 Query: 60 LAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLG 119 LAAG DKDGE ID L +GF +EIG+VTP+PQPGN +PR+F L + LINR GF + G Sbjct: 124 LAAGFDKDGEAIDGLFELGFSWVEIGSVTPKPQPGNPRPRVFHLPEDSSLINRYGFPSQG 183 Query: 120 VDNLVENVKKA-------------HYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYA 166 +++ ++ +L +N+GKNK++P DD++ + Y+ Sbjct: 184 HASVLSRIRSRIPPFTSGPNRASLREGCLLAVNLGKNKESP-ADSIDDFVTGVRTFGPYS 242 Query: 167 GYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQ--AMHHKYVPIAVKIAPDLSE 224 + +N+SSPNTPGLR LQ + L+ LL + +++L + + + +K APDL+E Sbjct: 243 DVLVVNVSSPNTPGLRGLQNRDVLERLLDGVTKARDELSPSVLTFRKPKLVLKFAPDLNE 302 Query: 225 EELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSL 284 EL +AD + +IDGVI +NTT+ R N + GGLSG P++ S + +R L Sbjct: 303 SELADIADVIRNSSIDGVIVSNTTVQRPKSLVNPNKSEMGGLSGPPVKPLSLKALRILRG 362 Query: 285 ELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 L +P+IG GGI + A E AGAS+VQ+Y+GF + G + I + Sbjct: 363 HLPASIPLIGCGGISTGADALEFAKAGASMVQVYTGFGYDGVGACRRIKDQV 414 >UniRef50_C6XQ80 Dihydroorotate dehydrogenase n=1 Tax=Hirschia baltica ATCC 49814 RepID=C6XQ80_HIRBI Length = 362 Score = 344 bits (882), Expect = 3e-93, Method: Composition-based stats. Identities = 136/332 (40%), Positives = 197/332 (59%), Gaps = 4/332 (1%) Query: 9 ALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCM--GLTFKNPLGLAAGLDK 66 + QL PE AH T ++ + L +++ V+ GL NPLG+AAG DK Sbjct: 11 LIQQLPPETAHRATIAAMKFGLAGKAKPLSKKQSERLKVHLPISGLDLPNPLGIAAGFDK 70 Query: 67 DGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVEN 126 + + A+G G +E GTVTP+ Q GN KPRLFRL + G+INRMGFNN G+D+ V Sbjct: 71 NADAFVPSLALGCGFVECGTVTPQLQDGNPKPRLFRLKEDGGVINRMGFNNSGLDSFVHR 130 Query: 127 VKK-AHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQ 185 +K A GV+G N+G NK + E+ DY+ ++ ++ Y YI +NISSPNTPGLR LQ Sbjct: 131 LKNGAANQGVVGANVGANKTSEGEKRVGDYVDGIKAVWQYCAYITLNISSPNTPGLRGLQ 190 Query: 186 YGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVAD-SLVRHNIDGVIA 244 L LLTA +++ H P+ +KIAPD+ EE + + D L+ + G+I Sbjct: 191 NKSDLSALLTAASETILEMEDRHKTKRPVFLKIAPDIDEEAIRDIVDTVLLAKGMTGLIV 250 Query: 245 TNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAA 304 +NTT++R +N QTGGLSG+PL KST+++++++ +G+L IIG GGI +A Sbjct: 251 SNTTIERPSFLQSENAKQTGGLSGKPLFEKSTQVLKQVARIADGQLDIIGAGGIHDAKSA 310 Query: 305 REKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 KI AGA Q+YS +++G LI EI+ + Sbjct: 311 YLKIRAGAHCFQLYSALVYEGAALIPEILNGL 342 >UniRef50_Q30R79 Dihydroorotate dehydrogenase n=10 Tax=Campylobacterales RepID=PYRD_SULDN Length = 352 Score = 343 bits (880), Expect = 5e-93, Method: Composition-based stats. Identities = 142/340 (41%), Positives = 192/340 (56%), Gaps = 18/340 (5%) Query: 3 YPFVRKALFQLDPERAHEFTFQQLRR--ITGTPFEALVRQKV---PAKPVNCMGLTFKNP 57 Y ++ LF+L+PE AH LR + F + G TF NP Sbjct: 4 YQSIKPWLFKLEPEDAHMLAEAALRIPNVCQVAFNPFLESHFITNSILKQELFGRTFFNP 63 Query: 58 LGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNN 117 +GL AG DK+ I A+ +GFG EIGT+TP+ Q GN KPR+FR ++ + + N MGFNN Sbjct: 64 IGLGAGFDKNATMIRAMQILGFGFTEIGTITPKAQAGNPKPRMFRHIEEQSIQNAMGFNN 123 Query: 118 LGVDNLVENVKKA-HYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSP 176 G+ + + +KK + +GINIGKNK TP Q +DY ++ ++ Y+ INISSP Sbjct: 124 EGLLSAQKRLKKRFPFTTPIGINIGKNKLTPDTQAINDYTTLIKALHELGDYLVINISSP 183 Query: 177 NTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVR 236 NTPGLR LQ E + L K + PI +KIAPD+S+E+ + + V Sbjct: 184 NTPGLRDLQNEEFITKLFEESKAITSK---------PILLKIAPDMSKEDAVALTKLAVL 234 Query: 237 HNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVG 296 DG+IATNTT+D SLV+ K+ GGLSG L+ KS EI ++ EL G+ +I VG Sbjct: 235 KGADGIIATNTTVDYSLVKEPKSI---GGLSGAVLKEKSFEIFEAVAKELYGKTTLISVG 291 Query: 297 GIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 GI S +I AGASLVQIYSG I++GP LIK I + Sbjct: 292 GISSAKEVYRRIKAGASLVQIYSGLIYEGPDLIKNINNEL 331 >UniRef50_D1SB76 Dihydroorotate dehydrogenase n=2 Tax=Micromonospora aurantiaca ATCC 27029 RepID=D1SB76_9ACTO Length = 377 Score = 342 bits (879), Expect = 8e-93, Method: Composition-based stats. Identities = 145/343 (42%), Positives = 203/343 (59%), Gaps = 20/343 (5%) Query: 1 MYYPFVRKALFQL---DPERAHEFTFQQLRRITGTP--FEALVRQKVPAKPVNCMGLTFK 55 ++ VR LF L D E AHE+T +L ++ P AL + P G+ F Sbjct: 44 IFEKVVRPRLFSLAGGDAEGAHEWTLARLAAVSRQPAVLAALRAAYFRSAPRTVFGVRFP 103 Query: 56 NPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGF 115 NP+GLAAG+DK+G + A A+GFG +E+GTVT QPGN +PRLFRL D+E +INRMGF Sbjct: 104 NPVGLAAGMDKNGLALPAWPALGFGFVEVGTVTAHAQPGNPRPRLFRLRDSEAVINRMGF 163 Query: 116 NNLGVDNLVENVKKAHYD--GVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINI 173 NN G + L + + LGI++GK+K TP+++ +DYL + + Y A+N+ Sbjct: 164 NNAGAEALADRLAALPRPLGVPLGISLGKSKVTPLDEAVEDYLASYRALKDHGDYFAVNV 223 Query: 174 SSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADS 233 SSPNTPGLR+LQ LD LL A+ ++ P+ VKIAPDL+E + ++ + Sbjct: 224 SSPNTPGLRSLQDRSHLDALLAALVGEK-----------PVLVKIAPDLTEPAVAELLEV 272 Query: 234 LVRHNIDGVIATNTTLDRSLVQG--MKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLP 291 + GVIATNTTL R + + + GGLSGRPL ++ E++ + E GRLP Sbjct: 273 CLDRGAAGVIATNTTLARDGLAPADRERAAEAGGLSGRPLTARAREMVAFVHRETGGRLP 332 Query: 292 IIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVT 334 +IGVGGI A AGASL+Q+Y+GFI++GP L + I T Sbjct: 333 VIGVGGILHPDDATRMFDAGASLLQLYTGFIYRGPALTRAITT 375 >UniRef50_P74782 Dihydroorotate dehydrogenase n=24 Tax=Bacteria RepID=PYRD_SYNY3 Length = 381 Score = 342 bits (877), Expect = 1e-92, Method: Composition-based stats. Identities = 134/356 (37%), Positives = 198/356 (55%), Gaps = 29/356 (8%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGTP----------FEALVRQKVPAKPVNCMG 51 YP + + DPER H+ Q L+++ E P C G Sbjct: 8 LYPLILSV-TKSDPERGHQRLIQTLKKVDTMHRNGFAVAMEQLEQAFTHADPRLQQTCWG 66 Query: 52 LTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLIN 111 L F N LGL+AG DK+GE A+GFG E+G VT QPGND+PRLFRL + ++N Sbjct: 67 LNFPNVLGLSAGCDKEGEAAAVWPALGFGFAELGAVTKYAQPGNDRPRLFRLPQDQAVLN 126 Query: 112 RMGFNNLGVDNLVENVKKA----HYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAG 167 R+G NN G + +K +GIN+ K+K TP++Q +DY+ + + A Sbjct: 127 RLGANNEGAVAMAAKLKHTWDYYPRTIPIGINLCKSKITPLDQAVEDYVFSFQTLAPVAD 186 Query: 168 YIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEEL 227 Y +N+SSPNTPGLR+LQ + L + LQ+ +H P+ VKI+PDLS E + Sbjct: 187 YFVVNVSSPNTPGLRSLQESDELPRIFAG-------LQSANHWQKPLLVKISPDLSWEAI 239 Query: 228 IQVADSLVRHNIDGVIATNTTLDRSLVQ-------GMKNCDQTGGLSGRPLQLKSTEIIR 280 + D + HN+ G++ATNT+ RS ++ G + GGLSG+P++ ++TE+IR Sbjct: 240 AVIIDLVKEHNLSGIVATNTSTRRSGLKTKILPQTGQPIEQEAGGLSGQPIRDRATEVIR 299 Query: 281 RLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + + G +PIIGVGGI + A EKI AGAS +QIY+G+I+ GP ++ +I+ + Sbjct: 300 YIYQQTGGTIPIIGVGGIFTAEDAWEKIQAGASFLQIYTGWIYGGPWVVSDILQGL 355 >UniRef50_B3DX48 Dihydroorotate dehydrogenase n=1 Tax=Methylacidiphilum infernorum V4 RepID=PYRD_METI4 Length = 348 Score = 341 bits (875), Expect = 2e-92, Method: Composition-based stats. Identities = 129/343 (37%), Positives = 182/343 (53%), Gaps = 19/343 (5%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALV---RQKVPAKPVNCMGLTFKNP 57 +Y F+R LF L+PE AH L F L+ ++ +P P G+ F NP Sbjct: 2 IYKSFLRPILFSLEPEYAHNLCLGLLSHPFYPFFHKLLASFQKDLPLLPKELWGMQFPNP 61 Query: 58 LGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNN 117 +GLAAG DK+G + A + GFG +EIGTVTP PQ GN PRL RL L N +GF + Sbjct: 62 VGLAAGFDKNGVGLRAWESFGFGFVEIGTVTPLPQEGNPAPRLCRLPKEGALWNSLGFPS 121 Query: 118 LGVDNLVENVKKA----HYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINI 173 G + E +KK +GINIGKN+ TP+E+ +DY C + +N+ Sbjct: 122 QGAQRVAERLKKVFLSGRPKIPVGINIGKNRHTPLEETIEDYKKCFSYFKDLGDFFVVNV 181 Query: 174 SSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADS 233 SSPNTPGL++LQ L+ L + P+ VKIAPD+ + L + + Sbjct: 182 SSPNTPGLKSLQQKRFLELLFDRLNPLN------SSPRKPLLVKIAPDIELKNLAGILEV 235 Query: 234 LVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPII 293 L+R+ G++ NT + + GGLSG+PL+ S +IR + E GRLPII Sbjct: 236 LLRNESVGIVIANTLPAKG------PGGKEGGLSGKPLRELSLGLIRFVKKETAGRLPII 289 Query: 294 GVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 GVGGI S A EK+ AGA L++I++GF++ GP + + Sbjct: 290 GVGGIFSSKDAFEKMEAGADLIEIFTGFVYNGPSFPANLCREL 332 >UniRef50_B9L4A8 Dihydroorotate oxidase n=2 Tax=Thermomicrobia (class) RepID=B9L4A8_THERP Length = 374 Score = 339 bits (870), Expect = 7e-92, Method: Composition-based stats. Identities = 130/343 (37%), Positives = 193/343 (56%), Gaps = 8/343 (2%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKV------PAKPVNCMGLTF 54 Y V LF+LDPE AH L R++ P V ++V V LTF Sbjct: 15 WYRRIVTPLLFRLDPEDAHRLVLGVLSRLSRCPGSERVLRRVFRVPDDERLRVEVGDLTF 74 Query: 55 KNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMG 114 NP+GLAAG+DK+ E + A +GFGS+E+GTVTP PQ GN +PRL+R + E L+N +G Sbjct: 75 PNPIGLAAGVDKNAEAVAAWFGLGFGSVEVGTVTPCPQEGNPRPRLWRFPEDETLVNALG 134 Query: 115 FNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINIS 174 F + GV + + + G +GIN+GKN TP+EQ DY + ++ A Y+ +N+S Sbjct: 135 FPSDGVAAVRARLVGRWFPGPVGINLGKNAWTPLEQAVVDYCATLVALWDVADYVVVNVS 194 Query: 175 SPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHH-KYVPIAVKIAPDLSEEELIQVADS 233 SPNTPGLR LQ GE L+ +L A++ L A+ + P+ VK++ DL L + Sbjct: 195 SPNTPGLRELQRGERLEQVLAAVQETNRTLAALQRARPRPLFVKVSLDLDAGALADAIEI 254 Query: 234 LVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPII 293 V DG+I NT++D SL + GG+SGRPL+ ++ E++ + GRL +I Sbjct: 255 AVAVGADGLILGNTSIDPSL-RPAGAGALPGGVSGRPLRKRAVELLSNAADRAGGRLALI 313 Query: 294 GVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 VGG+ +++ GA LVQ+Y+G +F+GP L ++ + Sbjct: 314 SVGGVLETDDVIQRLRLGADLVQVYTGLVFRGPALPAVLLRGL 356 >UniRef50_C4QIG2 Dihydroorotate dehydrogenase n=3 Tax=Schistosoma RepID=C4QIG2_SCHMA Length = 379 Score = 339 bits (869), Expect = 1e-91, Method: Composition-based stats. Identities = 134/337 (39%), Positives = 188/337 (55%), Gaps = 23/337 (6%) Query: 14 DPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDGECIDA 73 D E AH + L P + R P GL F +P+GLAAG DKDG+ Sbjct: 45 DGETAHNLSV-YLASYGFIPHKQ--RNSFPQLKCKVFGLEFDHPIGLAAGFDKDGKAFMG 101 Query: 74 LGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKKAHYD 133 L GF IE+GTVTP PQ GN +PR+FR + E ++NR GFN+ G D + E +K ++ Sbjct: 102 LLNAGFSHIEVGTVTPNPQLGNARPRIFRWTEKEAVVNRCGFNSDGHDAVYERLKDRPWE 161 Query: 134 G--VLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALD 191 G V+G+N+G NK + DY+ + K A Y+ IN+SSPNTPGLR+LQ E L Sbjct: 162 GRGVIGVNLGCNKTSA--DPTADYVAGVRKFGEVADYLVINVSSPNTPGLRSLQTKEKLR 219 Query: 192 DLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHN--IDGVIATNTTL 249 DLL+ + +N L K PI +KI+PD +++ L + + + IDG+I +NTTL Sbjct: 220 DLLSKVLAARNQL----SKKTPILLKISPDENDQNLKDIVEVALDSKTRIDGMIISNTTL 275 Query: 250 ----------DRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGID 299 + K GGLSGRPL KST+ +R++S G +P+IGVGGI Sbjct: 276 TTYEEAVACGAAPIPGNNKQNVVYGGLSGRPLFEKSTDCLRKVSALTKGAIPLIGVGGIS 335 Query: 300 SVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 A K+ AGASLVQ+Y+ F+++GPP+ ++ I Sbjct: 336 CGEDALSKLNAGASLVQLYTSFVYQGPPVAHKVAREI 372 >UniRef50_B5Z6I2 Dihydroorotate dehydrogenase n=28 Tax=Campylobacterales RepID=PYRD_HELPG Length = 351 Score = 339 bits (869), Expect = 1e-91, Method: Composition-based stats. Identities = 134/342 (39%), Positives = 188/342 (54%), Gaps = 18/342 (5%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPF-----EALVRQKVPAKPVNCMGLTFK 55 M YP V+K LF LD E AHE + LR ++ + F + K P +GL F Sbjct: 1 MLYPLVKKYLFSLDAEDAHEKVCKILRTLSKSSFLCSLIHSQWGYKNPKLENEILGLNFP 60 Query: 56 NPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGF 115 NPLGLAAG DK+ + AL A GFG +E GT+T Q GN++PRLFR ++ E L N MGF Sbjct: 61 NPLGLAAGFDKNASMLRALIAFGFGYLEAGTLTNEAQVGNERPRLFRHIEEESLQNAMGF 120 Query: 116 NNLGVDNLVENVKK-AHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINIS 174 NN G + + A Y +GIN+GKNK +DY + + Y N+S Sbjct: 121 NNYGAVLGARSFNRFAPYKTPIGINLGKNKHIEQAHALEDYKAVLNQCLNIGDYYTFNLS 180 Query: 175 SPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSL 234 SPNTP LR LQ +++L K + P+ +KIAPDL ++++++ +S Sbjct: 181 SPNTPNLRDLQNKAFVNELFCMAKEMT---------HKPLFLKIAPDLEIDDMLEIVNSA 231 Query: 235 VRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIG 294 + G+IATNTT+D+SLV K + GGLSG+ L KS E+ + L+ + ++ Sbjct: 232 IEAGAHGIIATNTTIDKSLVFAPK---EMGGLSGKCLTKKSREVFKELAKAFFNKSVLVS 288 Query: 295 VGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 VGGI A E+I GASL+QIYS FI+ GP L + I+ + Sbjct: 289 VGGISDAKEAYERIKMGASLLQIYSAFIYNGPNLCQNILKDL 330 >UniRef50_A5U4G5 Dihydroorotate dehydrogenase n=31 Tax=Corynebacterineae RepID=PYRD_MYCTA Length = 357 Score = 338 bits (868), Expect = 2e-91, Method: Composition-based stats. Identities = 143/341 (41%), Positives = 193/341 (56%), Gaps = 15/341 (4%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGTPF-----EALVRQKVPAKPVNCMGLTFKN 56 YP VR+ LF + PE AH+ F LR + L+ P G+ F Sbjct: 1 MYPLVRRLLFLIPPEHAHKLVFAVLRGVAAVAPVRRLLRRLLGPTDPVLASTVFGVRFPA 60 Query: 57 PLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFN 116 PLGLAAG DKDG + + GAMGFG EIGTVT PQPGN PRLFRL D L+NRMGFN Sbjct: 61 PLGLAAGFDKDGTALSSWGAMGFGYAEIGTVTAHPQPGNPAPRLFRLADDRALLNRMGFN 120 Query: 117 NLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSP 176 N G L + + + +G+NIGK K TP +DY + A Y+ +N+SSP Sbjct: 121 NHGARALAIRLARHRPEIPIGVNIGKTKKTPAGDAVNDYRASARMVGPLASYLVVNVSSP 180 Query: 177 NTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVR 236 NTPGLR LQ E+L +L+A++ + P+ VKIAPDLS+ +L +AD V Sbjct: 181 NTPGLRDLQAVESLRPILSAVRAET---------STPVLVKIAPDLSDSDLDDIADLAVE 231 Query: 237 HNIDGVIATNTTLDRSLVQGMKNCD-QTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGV 295 ++ G++ATNTT+ R + GG+SG PL ++ +++RRL + RL +I V Sbjct: 232 LDLAGIVATNTTVSRDGLTTPGVDRLGPGGISGPPLAQRAVQVLRRLYDRVGDRLALISV 291 Query: 296 GGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 GGI++ A E+I AGASL+Q Y+GFI+ G K+I I Sbjct: 292 GGIETADDAWERITAGASLLQGYTGFIYGGERWAKDIHEGI 332 >UniRef50_P32747 Dihydroorotate dehydrogenase, mitochondrial n=2 Tax=Schizosaccharomyces RepID=PYRD_SCHPO Length = 443 Score = 337 bits (866), Expect = 3e-91, Method: Composition-based stats. Identities = 136/358 (37%), Positives = 188/358 (52%), Gaps = 45/358 (12%) Query: 15 PERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDGECIDAL 74 PE +H TP + + P+ V G F NP+GLAAG DK + I L Sbjct: 78 PEFSHRVAILAASW-GITPKDRV--ADDPSLAVEVWGKKFCNPIGLAAGFDKQADAISGL 134 Query: 75 GAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKKAHYDG 134 GF +EIG+VTP+PQPGN KPR FRL +INR GFN++G D ++ ++K Sbjct: 135 LNFGFSYLEIGSVTPKPQPGNPKPRYFRLKPDLSVINRYGFNSIGHDAILAKIQKRVRKY 194 Query: 135 V-----------------------------------LGINIGKNKDTPVEQGKDDYLICM 159 + LGIN+GKNK+ +DY+ + Sbjct: 195 IAKTSPQLLKQFDANPASCTDPAVLGVPRSLIPNKFLGINLGKNKN---GNEIEDYVEGV 251 Query: 160 EKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIA 219 +A + IN+SSPNTPGLR LQ AL LLTA+ +++N L + H P+ VKIA Sbjct: 252 RTFGNFADILVINVSSPNTPGLRNLQKKSALSTLLTAVVSERNKLNSPH---PPVLVKIA 308 Query: 220 PDLSEEELIQVADSLVRHNIDGVIATNTTLDRS-LVQGMKNCDQTGGLSGRPLQLKSTEI 278 PDL+EEEL +AD L + IDGVI NTT+ R ++ + ++TGGLSG PL+ + Sbjct: 309 PDLNEEELTDIADVLKKCKIDGVIVGNTTVQRPKTLKSTSHVEETGGLSGPPLKPIALNT 368 Query: 279 IRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 +R L L+ +PIIG GGI S A E AGA++VQ+Y+ + GP + +I I Sbjct: 369 LRTLRKHLSSDIPIIGCGGISSGKDAIEYARAGATMVQVYTALGYDGPVIAHKIKQEI 426 >UniRef50_B6KTR1 Dihydroorotate dehydrogenase n=4 Tax=Toxoplasma gondii RepID=B6KTR1_TOXGO Length = 592 Score = 337 bits (866), Expect = 3e-91, Method: Composition-based stats. Identities = 130/379 (34%), Positives = 193/379 (50%), Gaps = 49/379 (12%) Query: 2 YYPFVRKALFQ------LDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFK 55 +Y V LF+ LDPE AH +T + L + P + ++ A V+ GL F Sbjct: 185 FYEPVTSVLFRYFSSGPLDPETAHGYTME-LAKRGWLPVD--YDREESALNVDINGLKFL 241 Query: 56 NPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGF 115 +P+GLAAG DK E AL MGF +E+G++TP+PQPGN KPRLFRL + +INR GF Sbjct: 242 SPIGLAAGFDKHAEAPAALLRMGFSFLEVGSITPKPQPGNPKPRLFRLYEDRSVINRFGF 301 Query: 116 NNLGVDNLVENVKKAHY---------DGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYA 166 N+ G D ++ GVLG+++GKNK + E D ++K+ +A Sbjct: 302 NSNGADYAQTQLEAFSEARLRDPFTAQGVLGVSLGKNKTS--EDAVADLREGVKKLGRFA 359 Query: 167 GYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAM------------------- 207 ++ +N+SSPNTPGLR+LQ L ++ ++ + + L Sbjct: 360 DFLVVNLSSPNTPGLRSLQSASHLAAIIDGVQEELDALDRQAQAASQKQRNERRRHGGNP 419 Query: 208 ----------HHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGM 257 + VKIAPDLS EE +A + N+DG + +NTT+ R Sbjct: 420 EETKAFYANQTGRRPLFFVKIAPDLSMEEKESIAKVALEKNLDGFVVSNTTIQRPETLKS 479 Query: 258 KNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQI 317 +TGGLSGR L+ ST + + G+L II GG++S A +KI AGASLV++ Sbjct: 480 PAKSETGGLSGRALKHLSTACVSDMYKLTQGKLAIIATGGVESGRDALDKIEAGASLVEL 539 Query: 318 YSGFIFKGPPLIKEIVTHI 336 YS ++ GP + + + + Sbjct: 540 YSSMVYIGPQVARRVKNEL 558 >UniRef50_B9KHW9 Dihydroorotate dehydrogenase (PyrD) n=10 Tax=Rickettsiales RepID=B9KHW9_ANAMF Length = 389 Score = 336 bits (862), Expect = 7e-91, Method: Composition-based stats. Identities = 127/338 (37%), Positives = 196/338 (57%), Gaps = 11/338 (3%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPA-KPVNCMGLTFKNPLGL 60 ++ F F + PE AH L+ VR ++P + L F+ P+GL Sbjct: 39 FFRFSHSPRFWVPPEVAHGLVIFGLKHG----LFPEVRGQMPECLSIEVCHLRFRTPIGL 94 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAG DK+ E I L MGFG +E GTVT +PQ GN +PRLFR+VD + ++NR+GFNN G+ Sbjct: 95 AAGFDKNAEVIKPLIGMGFGFVEAGTVTKKPQSGNKRPRLFRIVDQKAVVNRLGFNNKGI 154 Query: 121 DNLVENVKKAHYDGVL-GINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTP 179 ++ + + + ++ G N+G NK +Y + +Y + YI IN+SSPNT Sbjct: 155 QRFIKKIDRKELNNLVFGANLGINKTCT--DPPAEYAEMVRSVYGLSSYITINVSSPNTA 212 Query: 180 GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNI 239 GLR LQ L ++L+++++ + + VPI +KIAPD+S+E +A+ +V+H I Sbjct: 213 GLRDLQNRGPLSEILSSVRDARRSVDQAE--SVPIFLKIAPDISDELKQDIAEEIVKHKI 270 Query: 240 DGVIATNTTLDRSLVQGMKNCDQT-GGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGI 298 G+I +NTT D SL+ +N T GGLSGRPL ST ++ + L ++ +IG GG+ Sbjct: 271 SGLIVSNTTTDLSLLGKDRNKSITQGGLSGRPLFDLSTTVLSEMYSLLRDKVILIGCGGV 330 Query: 299 DSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 S A +KI AGASLVQ+Y+ +++G ++K+I + Sbjct: 331 SSGAQALQKIKAGASLVQLYTALVYEGFGVVKKINMEL 368 >UniRef50_A8Q682 Putative uncharacterized protein n=1 Tax=Malassezia globosa CBS 7966 RepID=A8Q682_MALGO Length = 665 Score = 336 bits (861), Expect = 9e-91, Method: Composition-based stats. Identities = 128/393 (32%), Positives = 187/393 (47%), Gaps = 66/393 (16%) Query: 6 VRKALF------QLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLG 59 V + LF DPE + + + L + G T NP+G Sbjct: 73 VHRWLFPPMMELLTDPESGSKISIKLLEHGLAP---RDCGKDDEVLRTELFGKTLTNPIG 129 Query: 60 LAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLG 119 LAAG DK GE ID L +GFG +EIG++TP PQPGN PR+FRL +INRMGFN+ G Sbjct: 130 LAAGFDKQGEAIDGLFDLGFGLVEIGSITPEPQPGNPTPRMFRLPLDAAVINRMGFNSEG 189 Query: 120 VDN-----------LVENV----------------------------------------- 127 + V+ V Sbjct: 190 HEAVRERLHARLHKWVQRVLSAGEGLVSSVGAPAPEPTALAEAQVFANYPVINTSLLDDA 249 Query: 128 ---KKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTL 184 + D +L IN+GKNK + E DY+ ++ + AYA + IN+SSPNTPGLR L Sbjct: 250 HVPRSLKQDRLLSINLGKNKSS-REDSVVDYVKGVQALGAYADMLVINVSSPNTPGLRRL 308 Query: 185 QYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIA 244 Q L+ +L + ++D+ +P+ VK+APDLS+ EL VAD+ IDG+I Sbjct: 309 QRRSVLEGVLRDVVTARDDVAKQRIDSLPLVVKVAPDLSDAELEDVADAARASKIDGIIV 368 Query: 245 TNTTLDRS-LVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIA 303 +NTT+ R + ++ + GGLSG P++ + ++ + G++P+IG GGI + Sbjct: 369 SNTTVSRPAGLLSTQHVHEAGGLSGPPVKPLALHALQVIYKRSEGKIPLIGCGGIMTAED 428 Query: 304 AREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 A E AGAS VQ+Y+ ++GP L + I + Sbjct: 429 ALEFARAGASAVQLYTALAYRGPGLPRRIKDDL 461 >UniRef50_Q0GF37 Dihydroorotate dehydrogenase n=2 Tax=Ustilago maydis RepID=Q0GF37_USTMA Length = 677 Score = 335 bits (860), Expect = 1e-90, Method: Composition-based stats. Identities = 134/397 (33%), Positives = 197/397 (49%), Gaps = 65/397 (16%) Query: 1 MYYPFVRKALFQ-LDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLG 59 ++ AL LDPE A + + L + G NP+G Sbjct: 98 IHRWIAVPALKAFLDPESAQKLAVKMLETGLAP---RDLVDDDAVLETELFGRKLSNPIG 154 Query: 60 LAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLG 119 LAAG DK E ID L +GFG IEIG+VTP PQPGN +PR FRL++ INR GFN+ G Sbjct: 155 LAAGFDKQAEAIDGLLDLGFGFIEIGSVTPEPQPGNPQPRYFRLIEDNACINRFGFNSEG 214 Query: 120 VDNLVENVKKA------------------------------------------------- 130 + ++ ++ Sbjct: 215 HNVILSRLRDRIRRWLLHSSSVANLQDALLASPDSASVNARQLIATHPKSTSAFVDATDL 274 Query: 131 ----HYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQY 186 +LGIN+GKNK T E+ DDY+ +E++ YA I +N+SSPNTPGLR LQ Sbjct: 275 PRSLRPAKMLGINLGKNK-TSNEESVDDYVKGVERLGPYADMIIVNVSSPNTPGLRRLQR 333 Query: 187 GEALDDLLTAIKNKQNDLQAMHHK------YVPIAVKIAPDLSEEELIQVADSLVRHNID 240 L+DLLT + ++ + H + VP+ VKIAPDLSEEEL VAD+ ++ ID Sbjct: 334 RGVLEDLLTQVVRARDGMVESHLRFSDKKVAVPLLVKIAPDLSEEELHDVADAALKSGID 393 Query: 241 GVIATNTTLDRSL-VQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGID 299 G++ +NTT+ R ++ ++ +TGGLSG P++ + + + + L G+LPIIG GGI Sbjct: 394 GLVISNTTISRPASLRSSEHVRETGGLSGAPVKPLALKALTTVHKRLQGKLPIIGCGGIS 453 Query: 300 SVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + A + AGAS +++Y+ F ++G L + + + Sbjct: 454 NGQDALDYAKAGASAIELYTSFGYQGVGLPRRLKDEL 490 >UniRef50_D2PV93 Dihydroorotate dehydrogenase n=1 Tax=Kribbella flavida DSM 17836 RepID=D2PV93_9ACTO Length = 394 Score = 335 bits (860), Expect = 1e-90, Method: Composition-based stats. Identities = 148/371 (39%), Positives = 199/371 (53%), Gaps = 42/371 (11%) Query: 2 YYPFVRKALFQL---DPERAHEFTFQQLRRITGTP-----FEALVRQKVPAKPVNCMGLT 53 Y VR L++L D E AHE T LRR+T P G+ Sbjct: 5 YRTLVRPVLYRLGRGDAEVAHEQTLHGLRRLTRVPGAVSALSRSYGALPAGLARTVFGVR 64 Query: 54 FKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRM 113 F +P+GLAAG+DK+G + A A+GFG +E+GTVT PQPGN+KPRLFRLV++E +INRM Sbjct: 65 FPSPVGLAAGMDKNGIALPAWRALGFGFVEVGTVTAHPQPGNEKPRLFRLVESEAVINRM 124 Query: 114 GFNNLGVDNLVENVKKAHYDG-VLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAIN 172 GFNNLG L + + G LGI+IGK+K TP+E +DY+ + ++Y + Y A+N Sbjct: 125 GFNNLGSAALADRLAAYGPLGYPLGISIGKSKVTPIEDAVEDYVTSLRRLYRFGDYFAVN 184 Query: 173 ISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKY--------------------- 211 +SSPNTPGLR+LQ L +LL A+ + L Sbjct: 185 VSSPNTPGLRSLQDAGHLRELLAALHTEAAALAGSGSGSGFGATSGSGAESRSGAESGSG 244 Query: 212 ----------VPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQG--MKN 259 PI VKIAPDL+E + ++ + G+IATNTT+ R + Sbjct: 245 AESGSGSGAVKPILVKIAPDLTEAAIDELLGVCTDAGVAGIIATNTTIGREALAPADQAL 304 Query: 260 CDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYS 319 + GGLSGRPL S + + + E G LPIIGVGGI A I AGASLVQ+Y+ Sbjct: 305 AAEAGGLSGRPLTEISAKTVAHIHAETGGALPIIGVGGILDPSDAARLIDAGASLVQLYT 364 Query: 320 GFIFKGPPLIK 330 G I++GP L++ Sbjct: 365 GLIYRGPGLVR 375 >UniRef50_Q8D370 Dihydroorotate dehydrogenase n=46 Tax=Gammaproteobacteria RepID=PYRD_WIGBR Length = 337 Score = 335 bits (860), Expect = 1e-90, Method: Composition-based stats. Identities = 175/335 (52%), Positives = 237/335 (70%), Gaps = 1/335 (0%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 M Y + L + D E + + ++ TP L++ K P ++CMGL FKN LGL Sbjct: 1 MIYKIINFILSKKDHEEKKDLLLKIMKFFNKTPLNFLIKNKFPNNNISCMGLNFKNILGL 60 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAGLDK+G+ I +GFG IE+GTVT +PQ G KPRLF + G+INRMGFNN G+ Sbjct: 61 AAGLDKNGDYIKLFSDIGFGFIELGTVTLKPQHGEKKPRLFCFPNVYGIINRMGFNNNGI 120 Query: 121 DNLVENVK-KAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTP 179 +NL+EN+K + + +LGINIGKNKDT +E+ KDDYLIC+ K Y Y+ YI+INISSPNT Sbjct: 121 ENLIENIKNEKNVKSILGINIGKNKDTLIEKAKDDYLICINKAYYYSDYISINISSPNTK 180 Query: 180 GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNI 239 LR LQ+GE DLL +IK +QN L +++KYVPI +KI+PD++ E+IQ++D L+ +NI Sbjct: 181 DLRKLQFGELFSDLLKSIKEEQNKLNKIYNKYVPILIKISPDINNSEIIQISDCLLSYNI 240 Query: 240 DGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGID 299 DGVIATNTT+++ ++ N + GGLSG PL ST II++LS EL G++PIIG GGI Sbjct: 241 DGVIATNTTVNKDIIMRCCNNCEKGGLSGAPLNENSTRIIKKLSKELKGKIPIIGSGGII 300 Query: 300 SVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVT 334 SV +A+EKI AGASL+QIYSG +F G +IK+++ Sbjct: 301 SVKSAKEKIKAGASLIQIYSGLVFFGLKIIKKLIK 335 >UniRef50_B3L830 Dihydroorotate dehydrogenase, putative n=1 Tax=Plasmodium knowlesi strain H RepID=B3L830_PLAKH Length = 556 Score = 335 bits (859), Expect = 2e-90, Method: Composition-based stats. Identities = 130/361 (36%), Positives = 196/361 (54%), Gaps = 32/361 (8%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 +Y F++ L +D E H+ F + + P++ GL F NP G+ Sbjct: 179 LYDIFLKFLLKYVDGEMCHDL-FLLMGKYNMLPYDTSKDSIYSC--TGIGGLNFINPFGV 235 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAG DK+G CID + +GF IE+GT+TP+PQ GNDKPR+FR V+ +IN GFNN+G Sbjct: 236 AAGFDKNGVCIDGILKLGFSFIEVGTITPKPQKGNDKPRIFRDVETRSIINCCGFNNIGC 295 Query: 121 DNLVENVKKAH---------YDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAI 171 D + EN+K+ + +G+++GKNKD+ +D C+ +I YA YIAI Sbjct: 296 DEVTENLKRFREKQKTDKLLHRHFVGVSLGKNKDSA--DILEDLSYCISRIGKYADYIAI 353 Query: 172 NISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMH----------------HKYVPIA 215 N+SSPNTPGLR Q E L ++ +K + + L+ + + + Sbjct: 354 NVSSPNTPGLRDNQQSERLQRIILRVKEEVDKLEESNVVGDDVVRGDTWVNTSKRKPLVF 413 Query: 216 VKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKS 275 VK+APDL E E ++AD L++ +DG+I NTT ++ ++ D+ GG+SG L+ S Sbjct: 414 VKLAPDLEEGEKKKIADVLLKTKVDGMIICNTTTEKFNIKNF--QDKKGGVSGEKLKDVS 471 Query: 276 TEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTH 335 T+ I ++ N ++PII GGI + A EKI AGAS+ Q+YS +F G I Sbjct: 472 TKFISQMYNYTNKKIPIIASGGIFTGKDALEKIEAGASVCQLYSCLVFNGMKAAVRIKRE 531 Query: 336 I 336 + Sbjct: 532 L 532 >UniRef50_Q75CE1 Dihydroorotate dehydrogenase, mitochondrial n=9 Tax=Saccharomycetales RepID=PYRD_ASHGO Length = 444 Score = 334 bits (857), Expect = 2e-90, Method: Composition-based stats. Identities = 140/362 (38%), Positives = 193/362 (53%), Gaps = 36/362 (9%) Query: 4 PFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAAG 63 P VR L D E H+ L+ G + + + P V G T NP+G AAG Sbjct: 70 PLVR--LVTPDAEDGHKLGIWFLK--YGLAPKLMFDKDDPVLKVEVFGKTMSNPIGCAAG 125 Query: 64 LDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV--- 120 LDKDGE ID + GFG +EIGTVTP QPGN KPR FRL E +INR GFN+ G Sbjct: 126 LDKDGEAIDGIAQSGFGYVEIGTVTPLAQPGNPKPRFFRLPMDEAVINRYGFNSSGHKKV 185 Query: 121 -DNLVENVKK---------------AHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYA 164 DN++ V++ + D +LGIN+GKNK+ +DYL +EK + Sbjct: 186 YDNVLSRVRQFLGAYFRDDTVNSLALYKDKLLGINLGKNKN---GDEVEDYLRGVEKFQS 242 Query: 165 YAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDL------QAMHHKYVPIAVKI 218 A + IN+SSPNTPGLR LQ L +LL+ I K+N L P+ VKI Sbjct: 243 LADVLVINVSSPNTPGLRDLQQEGRLTELLSMIVAKRNSLINEGNVLGASTHKPPVLVKI 302 Query: 219 APDLSEEELIQVADSLVRHNIDGVIATNTTLDRS---LVQGMKNCDQTGGLSGRPLQLKS 275 APDL+E EL +A++ + +IDG+I +NTT+ R + +Q GGLSG+P++ + Sbjct: 303 APDLTEPELQSIAEAAKKSSIDGIIVSNTTIQRPDSLYTVDEELKNQAGGLSGKPVKPFA 362 Query: 276 TEIIRRLSLELNG-RLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVT 334 + +R + L ++G GGI S A E AGA VQ+Y+ + ++GP LI I Sbjct: 363 LKALRTIHQYTKDTNLVLVGCGGISSGQDAIEFAKAGAHFVQLYTAYAYRGPGLIARIKD 422 Query: 335 HI 336 + Sbjct: 423 EV 424 >UniRef50_Q827Q6 Dihydroorotate dehydrogenase n=12 Tax=Actinomycetales RepID=PYRD_STRAW Length = 368 Score = 334 bits (857), Expect = 3e-90, Method: Composition-based stats. Identities = 143/346 (41%), Positives = 203/346 (58%), Gaps = 12/346 (3%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPF-----EALVRQKVPAKPVNCMGLTFK 55 MY F R ++DPE+AH F+ +R P A + + GL Sbjct: 1 MYKLFFRLVFKRMDPEQAHYLAFRWIRLAARIPVLRTFVAAALAPRFKELRTEAFGLRMH 60 Query: 56 NPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGF 115 P GLAAG DK+ +D + +GF +EIGTVT PQPGN K RLFRLV LINRMGF Sbjct: 61 GPFGLAAGFDKNAVAVDGMSMLGFDHVEIGTVTGEPQPGNPKKRLFRLVPDRALINRMGF 120 Query: 116 NNLG--VDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINI 173 NN G ++A + V+G+NIGK K P E+ DDY+ E++ +A Y+ +N+ Sbjct: 121 NNEGSAAVAARLAAREAVFRTVVGVNIGKTKVVPEEEAADDYVKSTERLARHADYLVVNV 180 Query: 174 SSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADS 233 SSPNTPGLR LQ EAL LL+A++ + + + + VP+ VKIAPDL+++++ VAD Sbjct: 181 SSPNTPGLRNLQATEALRPLLSAVREAAD--RTVTERRVPLLVKIAPDLADDDIDAVADL 238 Query: 234 LVRHNIDGVIATNTTLDRSLV---QGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRL 290 V +DG+IATNTT+ R + +TGGLSG PL+ +S E++ RL + R+ Sbjct: 239 AVELGLDGIIATNTTIAREGLGLKSEPTLVKETGGLSGAPLKARSLEVLSRLYARVGDRI 298 Query: 291 PIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 ++GVGGI++ A ++I AGA+LVQ YS FI++GP + I + Sbjct: 299 TLVGVGGIENAEDAWQRILAGATLVQGYSAFIYEGPFWGRAIHKGL 344 >UniRef50_B7JXU8 Dihydroorotate dehydrogenase n=8 Tax=Cyanobacteria RepID=PYRD_CYAP8 Length = 377 Score = 333 bits (855), Expect = 4e-90, Method: Composition-based stats. Identities = 136/357 (38%), Positives = 201/357 (56%), Gaps = 30/357 (8%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGTP-----------FEALVRQKVPAKPVNCM 50 +YP V A + +PE AH L + T + Sbjct: 8 FYPLVLTAA-KSNPEGAHLQLLNTLNTLERTHHTRGGNWLLSQLDQSFCVDDSRLKQTLW 66 Query: 51 GLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLI 110 GLTF NP+GLAAG DK+G +GFG E+G VT PQPGN +PRLFRL + ++ Sbjct: 67 GLTFNNPVGLAAGCDKEGIAAGIWSHLGFGFAELGAVTLHPQPGNPRPRLFRLPHDKAVL 126 Query: 111 NRMGFNNLGVDNLVENV----KKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYA 166 NR+G NN G + + + + +++ + +GIN+ K+K TP+++ DY+ + A Sbjct: 127 NRLGANNQGAEIMAQTLAEIWQRSPRNIPIGINLCKSKITPLDEAAQDYVGSFSYLENQA 186 Query: 167 GYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEE 226 Y +N+SSPNTPGLR+LQ GE L+ +L A LQA + P+ VKI+PDL EE Sbjct: 187 DYFVVNVSSPNTPGLRSLQEGEQLNSILQA-------LQAANQHQKPLFVKISPDLEEEA 239 Query: 227 LIQVADSLVRHNIDGVIATNTTLDRSLV-------QGMKNCDQTGGLSGRPLQLKSTEII 279 ++ + + H + G+IATNTT+ R + G K ++ GG+SG P++ +STEII Sbjct: 240 ILTIIELAQTHCLAGIIATNTTIKRDRLTTQILPETGNKIQEEAGGISGLPIRDRSTEII 299 Query: 280 RRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + + G+LPIIGVGGI + A KI AGASL+Q+Y+G+I++GP +I +IV + Sbjct: 300 GFIYQKTQGKLPIIGVGGIFTPDDAWNKIIAGASLLQLYTGWIYQGPWIIPDIVRGL 356 >UniRef50_Q5UF20 Predicted dihydroorotate dehydrogenase n=1 Tax=uncultured alpha proteobacterium EBAC2C11 RepID=Q5UF20_9PROT Length = 378 Score = 333 bits (855), Expect = 5e-90, Method: Composition-based stats. Identities = 134/344 (38%), Positives = 184/344 (53%), Gaps = 12/344 (3%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 M + + K L E AH+ L G RQ V GL F NPLGL Sbjct: 1 MMWNLLAKLARHLPAEAAHQIAVAALHYNVG--PRPAQRQSKADLTVRIAGLEFANPLGL 58 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAG DK+ C + +GF +E+GT+TP+ QPGN KPR+FRL + +INR GFN+ G+ Sbjct: 59 AAGFDKNATCFNGAMGLGFAHVEVGTITPKRQPGNPKPRVFRLPEENAVINRYGFNSHGM 118 Query: 121 DNLVENV--KKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNT 178 D + +N+ + G+LG+N+G NK + DDY + + YA YI +NISSPNT Sbjct: 119 DRVAKNLYATASKRVGILGVNVGANKTS--NDPIDDYRQAVAMLAPYADYITLNISSPNT 176 Query: 179 PGLRTLQYGEALDDLLTA----IKNK--QNDLQAMHHKYVPIAVKIAPDLSEEELIQVAD 232 PGLR LQ L DLL A + + ++ + PI +KIAPDL ++L + D Sbjct: 177 PGLRNLQTKRHLADLLMAGFAGCREAGFEPACRSTGLRQKPIFLKIAPDLRHDDLATIVD 236 Query: 233 SLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPI 292 S V G+IATNTT+ R + + GGLSG PL ST I+ ++ RL + Sbjct: 237 SCVETGASGIIATNTTIARPTGLSGVHAGEVGGLSGGPLFAASTGILAEVARLSQNRLAL 296 Query: 293 IGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 IGVGG+ S A KI GA +VQ+Y+G +GP L I+ + Sbjct: 297 IGVGGVSSGWQAYAKILVGADMVQLYTGLALEGPHLPNRILHEL 340 >UniRef50_C3XDT6 Dihydroorotate dehydrogenase n=4 Tax=Helicobacter RepID=C3XDT6_9HELI Length = 357 Score = 332 bits (853), Expect = 7e-90, Method: Composition-based stats. Identities = 124/343 (36%), Positives = 192/343 (55%), Gaps = 17/343 (4%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGTPF-----EALVRQKVPAKPVNCMGLTFKN 56 +Y +R L++ D E+ H F + ++ P + + GL F N Sbjct: 3 FYKKIRPYLYKCDAEKIHNFAIKVMKMPQKIPLFESMIAKCYCRIHENLAQDIHGLHFYN 62 Query: 57 PLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFN 116 P+GLA+G DK+ E + L ++GFG +E+G+VT PQ GN+KPR+FR V+ E L N MGFN Sbjct: 63 PIGLASGFDKNAEAVRPLASLGFGYLELGSVTQMPQDGNEKPRMFRHVEEESLQNAMGFN 122 Query: 117 NLGVDNLVENVKKAH-YDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISS 175 N+G ++ ++K+ + + LGINIGKNK+ +Y + ++ + Y Y N+SS Sbjct: 123 NIGARGMLAHLKEVYPFCIPLGINIGKNKNIAQGDSLKNYELSLDTLKDYGDYFTFNLSS 182 Query: 176 PNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLV 235 PNTPGLR LQ + +L+ K+ N PI +KI+PD+ E ++ V D+ + Sbjct: 183 PNTPGLRDLQNESFVKELMEMAKSTTNK---------PIFIKISPDMEIESMLAVCDAAI 233 Query: 236 RHNIDGVIATNTTLDRSLVQGMKNCDQ--TGGLSGRPLQLKSTEIIRRLSLELNGRLPII 293 ++ ++G+IATNT++D SLV + GGLSG+ + KS E++R L + + +I Sbjct: 234 QNGVNGIIATNTSIDYSLVSNPVKKNDVCFGGLSGKAISTKSKEVLRILGKNFHKKTTLI 293 Query: 294 GVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 VGGI E+I GASLVQI S I++GP LI + + Sbjct: 294 SVGGIGDSNEVYERIKLGASLVQILSSMIYEGPTLISRMNNEL 336 >UniRef50_Q2GEM2 Dihydroorotate dehydrogenase n=2 Tax=Neorickettsia RepID=Q2GEM2_NEOSM Length = 348 Score = 331 bits (848), Expect = 3e-89, Method: Composition-based stats. Identities = 130/339 (38%), Positives = 185/339 (54%), Gaps = 14/339 (4%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 M+ + L +L+P AH+ T L+ G F + + P GL FKNP+G+ Sbjct: 1 MHEKLLVALLQRLNPSFAHDVTRVVLKHFPG--FVSQNSFEDPILESRVCGLHFKNPIGI 58 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAG DK+ EC+ AL +GFG IE+GTVT +PQ GN PRLFRL +INR+GFNN G+ Sbjct: 59 AAGFDKNAECVTALRRVGFGFIELGTVTLKPQKGNPSPRLFRLPQDGAIINRLGFNNKGI 118 Query: 121 DNLVENVKKAHYDG---VLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPN 177 ++++KKA LG+NIGKN + DY + + A YI +NISSPN Sbjct: 119 AYFLKSLKKAMTHMDLPPLGVNIGKNAVSS--NAVSDYARLAAYVSSVADYITLNISSPN 176 Query: 178 TPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRH 237 T LR +Q E L++LL A+K V I +K+APDL+E + + ++H Sbjct: 177 TVSLRDMQKVEILEELLIAVKAAV-------GSNVRIFIKVAPDLAEGAEVGIISLALKH 229 Query: 238 NIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGG 297 + G+I +NTT+ K+ + GGLSG PL ST ++R++ NG L IG GG Sbjct: 230 KVAGIIVSNTTIGCRESLHSKHKVEYGGLSGTPLFKLSTGLLRKMYRCTNGELVFIGCGG 289 Query: 298 IDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 I A KI GA+L+Q Y+ F + G L+ +I + Sbjct: 290 ISDAETAYAKIRNGAALIQAYTSFTYHGFGLLNQIKKDL 328 >UniRef50_D2UZD6 Predicted protein n=1 Tax=Naegleria gruberi RepID=D2UZD6_NAEGR Length = 369 Score = 330 bits (847), Expect = 4e-89, Method: Composition-based stats. Identities = 127/348 (36%), Positives = 202/348 (58%), Gaps = 30/348 (8%) Query: 13 LDPERAHEFTFQQLRRITGTPFEALVRQKVPAKP-----VNCMGLTFKNPLGLAAGLDKD 67 +DPE AH + ++ G + L + P NC+G F+NP+GLAAG DKD Sbjct: 1 MDPEDAHNLSKLAIKYGIGPKEKKLKANQYGLDPLISLHTNCLGYHFENPIGLAAGFDKD 60 Query: 68 GECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRL----VDAEG-----LINRMGFNNL 118 EC+ + +GFG +E+G++ P+PQPGN KPR+FRL D +G ++NR GFN+ Sbjct: 61 AECMKGIEKLGFGFMEVGSICPQPQPGNPKPRIFRLNSKVSDPDGTIFDTILNRCGFNSK 120 Query: 119 GVDNLVENVKKAHYDG------VLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAIN 172 G++ EN+ +G+N+GKNK + E +DYLI + K+ +A ++ IN Sbjct: 121 GMEVSDENLTTYRNSYQSLNTFPIGVNLGKNKTSAPE-SIEDYLIGVRKLAKHADFLVIN 179 Query: 173 ISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVAD 232 +SSPNT LR+LQ +LD L+ + + HK +P+ +KIAPDL+ ++ +A Sbjct: 180 VSSPNTQHLRSLQEKSSLDTLIEEVSTELKK-----HKNIPLLIKIAPDLTLDQQRDIAS 234 Query: 233 SLVRHNIDGVIATNTTLDRSLVQGMK----NCDQTGGLSGRPLQLKSTEIIRRLSLELNG 288 ++H+I G+I +NTT++R V + GG+SGRPL +ST++++ + G Sbjct: 235 LALKHSIGGIIVSNTTIERPFVSSEQINAIPNGSAGGMSGRPLFNQSTKVLKNMYKLTEG 294 Query: 289 RLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 ++ +IGVGG+ A +KI AGASLVQ+Y+ F +GP ++ +I + Sbjct: 295 KVTLIGVGGVWDGYDALQKIQAGASLVQVYTAFTAQGPAVVGKIKREL 342 >UniRef50_A2VBP6 Dihydroorotate dehydrogenase, mitochondrial n=1 Tax=Dekkera bruxellensis RepID=A2VBP6_DEKBR Length = 442 Score = 330 bits (846), Expect = 5e-89, Method: Composition-based stats. Identities = 120/352 (34%), Positives = 181/352 (51%), Gaps = 30/352 (8%) Query: 10 LFQL--DPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKD 67 LF+ E+ H L+ G A P V+ G T NP+G+AAG DK Sbjct: 74 LFRWCTTAEQGHHLGIALLK--YGIFPRAFGDHDDPILRVDLFGRTLANPIGMAAGFDKQ 131 Query: 68 GECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENV 127 E +DAL +GFG +E+GT+TP PQ GN +PR FRL E +INR G N+ G ++ + Sbjct: 132 AEAMDALYDLGFGIVEVGTITPEPQFGNPRPRFFRLNADETVINRYGLNSDGRLTILSRL 191 Query: 128 K-----------------KAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIA 170 + L +NIGKN++ DDYL+ ++ YA + Sbjct: 192 RVRLEKYLKKSNACKTNNSFREGKSLFVNIGKNRN---GDTIDDYLVGVDTFAPYADALV 248 Query: 171 INISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAM---HHKYVPIAVKIAPDLSEEEL 227 +N+S P+ PG+R LQ + L +LLT ++ +++ + A + PI VK+APDLSE+E+ Sbjct: 249 LNVSCPSAPGVRDLQEKDVLLELLTKVREERDKVGANVIDPARKPPIIVKVAPDLSEKEI 308 Query: 228 IQVADSLVRHNIDGVIATNTTLDR--SLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLE 285 +AD + IDG++ +NTT R SL+ + GGLSGR ++ S + R L Sbjct: 309 ADIADVAKKSKIDGILMSNTTTARPASLITKGPVVQEKGGLSGRAMRDISLKAFRTLRKY 368 Query: 286 LNG-RLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 L +IG GGI + A AGAS +++Y+ F ++GP + +I I Sbjct: 369 TKDSDLVLIGCGGIFTGKDAIAFAKAGASAIELYTSFAYRGPGIPDKIKDEI 420 >UniRef50_A9HBE5 Dihydroorotate oxidase n=10 Tax=Acetobacteraceae RepID=A9HBE5_GLUDA Length = 357 Score = 327 bits (839), Expect = 4e-88, Method: Composition-based stats. Identities = 123/345 (35%), Positives = 185/345 (53%), Gaps = 21/345 (6%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 + + + +LDPE AH + G + Q PA V +GL F NP+G+ Sbjct: 4 IMSNMLMPLVRRLDPEDAHRLGLNA--LLLGLGGGSGSGQDDPALAVRALGLRFPNPIGI 61 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAG DK+ + L +GFG +E GTVTPRPQPGN +PRLFRL + +INRMGFNN G+ Sbjct: 62 AAGFDKNALVVRPLARIGFGFVEAGTVTPRPQPGNPRPRLFRLDEDRAIINRMGFNNQGI 121 Query: 121 DNLVENVKKAHY----------DGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIA 170 D + + H +G N+G NK + DY + ++ YA Y+ Sbjct: 122 DRFAVRLARLHRVSPAGRHAGARVPVGANLGINKFGA--DPERDYPRLVGRVKHYADYVV 179 Query: 171 INISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQV 230 +N+SSPNTPGLR LQ L LL AI H P+ VK++PDL+ +++ + Sbjct: 180 LNLSSPNTPGLRDLQEASRLGALLQAIGEA-------HPDRPPLLVKLSPDLARDDIGPI 232 Query: 231 ADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRL 290 ++ + G+I TNTT+ R + + GGLSGRPL+ + +I R ++ GRL Sbjct: 233 VEAAIAGGAQGLIVTNTTISRPAGLRSPHAGEAGGLSGRPLRPLAADIFRAVAQVAAGRL 292 Query: 291 PIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTH 335 ++ GGI++ +++ AGA LVQ+YS F ++GP +++ + Sbjct: 293 ALVACGGIETGADIVDRVRAGADLVQLYSAFAYEGPGIVRRLKRE 337 >UniRef50_Q2S001 Dihydroorotate oxidase n=2 Tax=Rhodothermaceae RepID=Q2S001_SALRD Length = 366 Score = 326 bits (836), Expect = 7e-88, Method: Composition-based stats. Identities = 120/338 (35%), Positives = 180/338 (53%), Gaps = 19/338 (5%) Query: 14 DPERAHEFTFQQLRRITGTPF---EALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDGEC 70 +PE AH + R T + + + G TF NP+GLAAG DK+ Sbjct: 13 NPEWAHTASLWGARVAQRTVLPLVASRYQFEDERLKQRLWGDTFPNPVGLAAGADKNARA 72 Query: 71 IDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKKA 130 + A+GFG +E+G+V+ +P PGN PR FRL + LINR+G NN G + + + ++ + Sbjct: 73 VPFWEAVGFGFVEVGSVSAQPAPGNPTPRAFRLPKDQALINRLGLNNDGAEAVADRLEHS 132 Query: 131 HYD--GVLGINIGKNKDTPV--EQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQY 186 D LGIN+ K D + E +D+ ++ A Y+ +N+S PNTP T + Sbjct: 133 RSDRARPLGINLAKTHDPDIMGEAALEDFRTSFRQLVGQADYVTLNVSCPNTPDGGTFED 192 Query: 187 GEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEE-----ELIQVADSLVRHNIDG 241 ALD LL AI +Q VP+ VK++P LS+ L ++ H+IDG Sbjct: 193 PAALDALLGAITAEQKA----PGLAVPVLVKLSPPLSDRVLFDTRLEEILAVAADHDIDG 248 Query: 242 VIATNTTLDRSLVQGMKNC---DQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGI 298 IATNT DR V+ + GGLSG PL+ ++T +++ L +G +PIIGVGG+ Sbjct: 249 FIATNTASDRKGVETSADRLDEIGAGGLSGPPLEARATRLVQYLYRATDGEIPIIGVGGV 308 Query: 299 DSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 +A KI AGASLVQ+Y+ +++GP L++ I + Sbjct: 309 HDAESAYTKIRAGASLVQLYTALVYEGPGLVRRIKEGL 346 >UniRef50_D1B1W1 Dihydroorotate dehydrogenase n=2 Tax=Campylobacteraceae RepID=D1B1W1_SULD5 Length = 355 Score = 322 bits (826), Expect = 1e-86, Method: Composition-based stats. Identities = 128/341 (37%), Positives = 176/341 (51%), Gaps = 19/341 (5%) Query: 3 YPFVRKALFQLDPERAHEFTFQQLRRIT------GTPFEALVRQKVPAKPVNCMGLTFKN 56 Y ++K +F PE AH + P TF N Sbjct: 6 YGLMKKIMFNFSPETAHNIAEFFFKHGANYAPFILAPLAERFFIHDKRLEQTLFDRTFHN 65 Query: 57 PLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFN 116 P+GLAAG DK+ I L A+GFG IE GT+TP PQ GN KPR FR + E + N MGFN Sbjct: 66 PIGLAAGFDKNATMIKMLTALGFGHIEYGTMTPEPQSGNAKPRCFRFPEEESIQNAMGFN 125 Query: 117 NLGVDNLVENVKKAH-YDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISS 175 N G+ + + ++ + + L NIGKNK T E DY +++ + ++ +NISS Sbjct: 126 NEGMHKIAKRLESLYPFATPLAANIGKNKITSAENALKDYEKLIKRFKDVSDFLVVNISS 185 Query: 176 PNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLV 235 PNTPGLR LQ + +L K P+ +KIAPDL +E I++ + Sbjct: 186 PNTPGLRDLQNEAFIKELFMMAKELT---------CKPVLLKIAPDLEIKEAIELCSCAL 236 Query: 236 RHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGV 295 + G++ATNTT+D SL + N GG+SG+ L KS + ++ E G+ +I V Sbjct: 237 ENGAKGIVATNTTIDYSL---LPNAKDFGGISGKVLCEKSFRMFEGIAKEFFGKTTLISV 293 Query: 296 GGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 GGIDS A ++ AGASL+QIYS FIFKGP L + I I Sbjct: 294 GGIDSAEEAYRRLKAGASLLQIYSAFIFKGPSLNRTINLGI 334 >UniRef50_B9L9P6 Dihydroorotate dehydrogenase n=7 Tax=Epsilonproteobacteria RepID=PYRD_NAUPA Length = 359 Score = 321 bits (823), Expect = 2e-86, Method: Composition-based stats. Identities = 132/341 (38%), Positives = 199/341 (58%), Gaps = 18/341 (5%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGTP--FEALVRQKVPA---KPVNCMGLTFKN 56 ++ V+ +++ DPE AH+ +R P F LV+ L FKN Sbjct: 3 FFNMVKPLIYKTDPELAHDLVDLAMRTARRCPLFFNPLVKANFVDDVMLHQKIWDLEFKN 62 Query: 57 PLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFN 116 P+G+AAG DK + A+GFG EIG VTP+PQPGN+KPR +R ++ E + N GFN Sbjct: 63 PVGVAAGFDKHATMVYGWPALGFGWGEIGAVTPKPQPGNEKPRAWRHIEYEAVQNAYGFN 122 Query: 117 NLGVDNLVENVKKAH-YDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISS 175 N GV+ + + +KK + + +G NIGKNK TP E+ +DY I + ++ + +N+SS Sbjct: 123 NEGVEVIKKRLKKIYPFILPIGANIGKNKTTPEERAVEDYKILVNELKDVVDFFVVNVSS 182 Query: 176 PNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLV 235 PNTPGLR L E + L +KN + PI +K +PD+ +E +I +A+ V Sbjct: 183 PNTPGLRDLLNAEFISSLFGELKNLTDK---------PILIKFSPDMEDELIINLANYSV 233 Query: 236 RHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGV 295 DG+I TNTT++ LV + GG+SG+PL +S E++R ++ E+ G++PII V Sbjct: 234 LAGADGIIVTNTTVNYDLVNS---EIKRGGISGKPLAQRSYEVLRIVAGEVFGKVPIISV 290 Query: 296 GGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 GGIDS A ++I AGASL+Q+Y+ I+KGP ++ EI + Sbjct: 291 GGIDSAEEAYKRIKAGASLLQVYTAIIYKGPGIVGEINRGL 331 >UniRef50_A7AUQ8 Dihydroorotate dehydrogenase n=2 Tax=Piroplasmida RepID=A7AUQ8_BABBO Length = 415 Score = 321 bits (823), Expect = 2e-86, Method: Composition-based stats. Identities = 128/359 (35%), Positives = 191/359 (53%), Gaps = 30/359 (8%) Query: 2 YYPFVRKALF-QLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 Y + LDPE AH+ + L+ + P + V P + F NP+G+ Sbjct: 21 LYNVLMPLFRNYLDPEVAHKLSITALK-LGIAPVDYSV--DPPVIQSRLKDVVFFNPIGM 77 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAG DK E + MGFG +E+GTV P PQ GN KP +FRL D++ LIN GFN++G+ Sbjct: 78 AAGYDKQVEVPLQILRMGFGFVEVGTVLPLPQEGNPKPVMFRLHDSKALINCCGFNSVGL 137 Query: 121 DNLVENVKKAHY---------DGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAI 171 + +K+ D ++G+++GKN+ + D + ++ + YA YIAI Sbjct: 138 EVAKARLKRVRKKQASDPLTKDFMIGVSVGKNRTGDI---LADTVNAVKGVAPYADYIAI 194 Query: 172 NISSPNTPGLRTLQYGEALDDLLTA-----------IKNKQNDLQAMHHKYVPIAVKIAP 220 N+SSPNTP LR Q E L +++A IK+K + K + +KI+P Sbjct: 195 NVSSPNTPNLRDNQKREPLIAVISAARSALEIVNTEIKSKGAEFNNTTKKVPLLLIKISP 254 Query: 221 DLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNC---DQTGGLSGRPLQLKSTE 277 D+S +EL +AD + H++DG+IATNTT+ R V + GGLSGRPL+ S + Sbjct: 255 DVSRQELEDIADISLTHHVDGIIATNTTITRDNVVPSDLKTAGNPKGGLSGRPLKTMSKK 314 Query: 278 IIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 I+ L G++PII GGI + A E I AGASL QIY+ +++GP + + + Sbjct: 315 IVYDLYELTEGKIPIIACGGISTAQDALEMIEAGASLCQIYTALVYEGPGIPSRMKNGL 373 >UniRef50_Q7RLG4 Dihydroorotate dehydrogenase, putative n=2 Tax=Plasmodium (Vinckeia) RepID=Q7RLG4_PLAYO Length = 512 Score = 320 bits (821), Expect = 4e-86, Method: Composition-based stats. Identities = 135/356 (37%), Positives = 196/356 (55%), Gaps = 27/356 (7%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 MY F+ L +D E H+ F L + P++ + L F NP G+ Sbjct: 136 MYDVFLDLCLKYVDSEVCHDL-FLLLGKYGLLPYDTSNDSVYATS--DIKNLNFINPFGV 192 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAG DK+G CID++ +GF IEIGT+TP+PQ GNDKPR+FR V+ + +IN GFNN+G Sbjct: 193 AAGFDKNGICIDSILKLGFSFIEIGTITPKPQKGNDKPRIFRDVENKSIINACGFNNIGC 252 Query: 121 DNLVENV---------KKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAI 171 D + EN+ K ++G++IGKNK T E DD + KI YA YIAI Sbjct: 253 DKVTENLISFRKKQEEDKLLSKHIVGVSIGKNKYT--ENIVDDLKYSIYKIARYADYIAI 310 Query: 172 NISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHH-----------KYVPIAVKIAP 220 N+SSPNTPGLR Q L +++ +K + N ++ H K + VK+AP Sbjct: 311 NVSSPNTPGLRDNQESNKLKNIILFVKQEINKIEESGHNGENFWMNTTKKKPLVFVKLAP 370 Query: 221 DLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIR 280 DL E ++A L+ IDG+I +NTT+++ ++ + D+ GG+SG+ L+ ST +I Sbjct: 371 DLENSEKKKIAQVLLDTGIDGMIISNTTINKMDIKSFE--DKKGGVSGKKLKDLSTNLIS 428 Query: 281 RLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + + N ++PII GGI + A EKI AGAS+ Q+YS +F G +I Sbjct: 429 DMYIYTNKQIPIIASGGILTGADALEKIEAGASVCQLYSCLVFNGVKSAIQIKREF 484 >UniRef50_Q6SZS6 Dihydroorotate dehydrogenase, mitochondrial n=10 Tax=Saccharomycetales RepID=PYRD2_KLUMA Length = 446 Score = 319 bits (818), Expect = 8e-86, Method: Composition-based stats. Identities = 134/358 (37%), Positives = 194/358 (54%), Gaps = 36/358 (10%) Query: 10 LFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDGE 69 L D E H+ L+ + VN G T NP+G AAGLDKDGE Sbjct: 74 LLTPDAEAGHKLGIWLLKYGLAPRLW--FDKDEELLHVNVFGKTLTNPVGCAAGLDKDGE 131 Query: 70 CIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKK 129 ID + A GFG +EIG+VTP PQPGN KPR FRL E +INR GFN+ G D++V+N++ Sbjct: 132 AIDGIFAGGFGYVEIGSVTPLPQPGNPKPRFFRLPMDEAVINRYGFNSSGHDSVVKNLQN 191 Query: 130 A---------------------HYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGY 168 + + +LGIN+GKNK+ DYL +EK YA Sbjct: 192 RVSRFINSYFCNDINAVDNLSLYQNKLLGINLGKNKN---GDEVQDYLKGVEKFQKYADV 248 Query: 169 IAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHH------KYVPIAVKIAPDL 222 + IN+SSPNTPGLR LQ L +LL+ + K++ L + + P+ VK+APDL Sbjct: 249 LVINVSSPNTPGLRGLQKESILTNLLSQVVAKRDSLVSSGNVLGAKTHRPPVLVKVAPDL 308 Query: 223 SEEELIQVADSLVRHNIDGVIATNTTLDRS---LVQGMKNCDQTGGLSGRPLQLKSTEII 279 EEE+ +A++ + +DG+I +NTT+ R + + Q GGLSG+PL+ S + + Sbjct: 309 EEEEIKAIAEAAKKSKVDGIIVSNTTIQRPASLITEDKNLVAQAGGLSGKPLKPLSLKAL 368 Query: 280 RRLSLELNGR-LPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + ++ G L ++G GGI S A E AGA++V++Y+ + ++GP LI + I Sbjct: 369 KTMAHYTKGSGLVLVGCGGISSGADAIEFAKAGATMVELYTCYAYRGPGLIARVKDEI 426 >UniRef50_Q83GM4 Dihydroorotate oxidase n=2 Tax=Tropheryma whipplei RepID=Q83GM4_TROWT Length = 335 Score = 317 bits (814), Expect = 2e-85, Method: Composition-based stats. Identities = 121/340 (35%), Positives = 181/340 (53%), Gaps = 15/340 (4%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLA 61 Y + L +DPE AH L+ G MGL F PLG+A Sbjct: 1 MYSYFLNFLKCVDPELAHRIAAVALKSGLGMFVPQRFHIH---LGTTSMGLYFDTPLGIA 57 Query: 62 AGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVD 121 AG DK + + L ++GFG +E+GTVT PQPGN KPR+ R++ + LIN MGFNN G Sbjct: 58 AGFDKFADLVIPLYSLGFGHVEVGTVTLHPQPGNKKPRIHRVMSQKALINSMGFNNPGAQ 117 Query: 122 NLVENVKKAHYDG----VLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPN 177 + EN+ K G ++G+NIGK+K P+E+ DY+ E + + Y+ IN+SSPN Sbjct: 118 KMRENILKVRKSGRRLPIIGVNIGKSKVCPLEESAKDYVKSFELLADVSDYLVINVSSPN 177 Query: 178 TPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRH 237 T GLRTLQ L+ +L ++K + + P+ +KI+PDLS ++ +A + Sbjct: 178 TEGLRTLQSVGNLNKILRSVKPIADRFKR------PVLIKISPDLSNSDVTNIALLVKEF 231 Query: 238 NIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNG-RLPIIGVG 296 + GV+A+NTT R+ + + GGLSG L+ +S E+++ L +L + II VG Sbjct: 232 GLAGVVASNTTTKRTGL-PNEFSSLHGGLSGPMLKERSLEMLKILRRDLPKNKFCIISVG 290 Query: 297 GIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 G+ E++ GA LVQ Y+ F++ GP I + Sbjct: 291 GVWDYTDVLERLEYGADLVQGYTAFVYNGPYWASNINRDL 330 >UniRef50_A5K1N1 Dihydroorotate dehydrogenase, mitochondrial, putative n=1 Tax=Plasmodium vivax RepID=A5K1N1_PLAVI Length = 572 Score = 315 bits (807), Expect = 2e-84, Method: Composition-based stats. Identities = 134/387 (34%), Positives = 196/387 (50%), Gaps = 58/387 (14%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 +Y F++ L +D E HE F + + P++ GL F NP G+ Sbjct: 169 LYDVFLKMLLKYVDGETCHEL-FLLMGKYKLLPYDTGKDNIYSCS--EIKGLNFINPFGV 225 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAG DK+G CID + +GF IEIGT+TP+ Q GN++PR+FR ++ +IN GFNN+G Sbjct: 226 AAGFDKNGVCIDGILKLGFSFIEIGTITPKAQKGNERPRIFRDLETRSIINSCGFNNMGC 285 Query: 121 DNLVENVKKAH---------YDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAI 171 D + +N+K+ ++G+++GKNKD+P D C+ KI YA YIAI Sbjct: 286 DEVCKNLKRFRERQKTDKLLQRHLVGVSLGKNKDSP--DILQDLSYCIGKIGRYADYIAI 343 Query: 172 NISSPNTPGLRTLQYGEALDDLLTAIKNKQNDL-----------------------QAMH 208 N+SSPNTPGLR Q GE L ++ +K + L +A+ Sbjct: 344 NVSSPNTPGLRDHQKGERLHGIIQRVKEEVAKLDGGGAPLGGATTGGAAMGGATTGEAVV 403 Query: 209 HKYVP-------------------IAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTL 249 K P I VK+APDL E E +A+ L+ +DG+I NTT Sbjct: 404 GKAPPDEAATGGEPWANTTKRRPLIFVKLAPDLEEGERKSIANVLLNAEVDGMIICNTTT 463 Query: 250 DRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIA 309 + ++ + D+ GG+SG L+ ST +I ++ NG++PII GGI + A EKI Sbjct: 464 QKFNIKSFE--DKKGGVSGEKLKGVSTHMISQMYNYTNGKIPIIASGGIFTGEDALEKIE 521 Query: 310 AGASLVQIYSGFIFKGPPLIKEIVTHI 336 AGAS+ Q+YS +F G I + Sbjct: 522 AGASVCQLYSCLVFNGMKAAVRIKREL 548 >UniRef50_Q7U3U2 Dihydroorotate dehydrogenase n=30 Tax=cellular organisms RepID=PYRD_SYNPX Length = 396 Score = 315 bits (807), Expect = 2e-84, Method: Composition-based stats. Identities = 125/316 (39%), Positives = 174/316 (55%), Gaps = 21/316 (6%) Query: 34 FEALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQP 93 ++++ G F NP+GLAAG DK+G GFG E+GTVT QP Sbjct: 58 LAGDLQRRDLRLEQVLFGCRFPNPVGLAAGFDKNGVAAGLWDRFGFGFAEVGTVTWHGQP 117 Query: 94 GNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKKA------HYDGVLGINIGKNKDTP 147 GN +PRLFRL + +NRMGFNN G L +++ VLGIN+GK+K T Sbjct: 118 GNPRPRLFRLAQEQAALNRMGFNNDGAQALRRTLERQRLAPPGRRPAVLGINVGKSKVTA 177 Query: 148 VEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAM 207 +EQ +DY +E + A Y IN+SSPNTPGLR LQ ++ + + Sbjct: 178 LEQAPEDYASSLELLAPLADYAVINVSSPNTPGLRDLQD--------SSQLRRLVERLRR 229 Query: 208 HHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMK-------NC 260 P+ VKIAPDL +E + +A + GVIA NT+LDR ++ + Sbjct: 230 LPACPPLLVKIAPDLEDEAIDGIARLAFEEGLAGVIAVNTSLDRLGLEQRRLLQTGRTLA 289 Query: 261 DQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSG 320 ++ GGLSG PL+ ++ E+IRRL L +IGVGGIDS A E+I AGASL+Q+Y+G Sbjct: 290 EEAGGLSGAPLRQRALEVIRRLRASAGPALTLIGVGGIDSAEIAWERITAGASLIQLYTG 349 Query: 321 FIFKGPPLIKEIVTHI 336 +IF+GP L+ I+ + Sbjct: 350 WIFQGPELVPRILEGL 365 >UniRef50_Q08210 Dihydroorotate dehydrogenase homolog, mitochondrial n=4 Tax=Plasmodium RepID=PYRD_PLAF7 Length = 569 Score = 313 bits (803), Expect = 5e-84, Method: Composition-based stats. Identities = 137/387 (35%), Positives = 199/387 (51%), Gaps = 58/387 (14%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 +Y F++ L +D E H+ F L + P++ N L F NP G+ Sbjct: 167 LYDIFLKFCLKYIDGEICHDL-FLLLGKYNILPYDTSNDSIYAC--TNIKHLDFINPFGV 223 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAG DK+G CID++ +GF IEIGT+TPR Q GN KPR+FR V++ +IN GFNN+G Sbjct: 224 AAGFDKNGVCIDSILKLGFSFIEIGTITPRGQTGNAKPRIFRDVESRSIINSCGFNNMGC 283 Query: 121 DNLVENV---------KKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAI 171 D + EN+ K ++G++IGKNKDT DD C+ KI YA YIAI Sbjct: 284 DKVTENLILFRKRQEEDKLLSKHIVGVSIGKNKDTV--NIVDDLKYCINKIGRYADYIAI 341 Query: 172 NISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQA------------------------- 206 N+SSPNTPGLR Q L +++ ++K + ++L+ Sbjct: 342 NVSSPNTPGLRDNQEAGKLKNIILSVKEEIDNLEKNNIMNDESTYNEDNKIVEKKNNFNK 401 Query: 207 -----------------MHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTL 249 K + VK+APDL++E+ ++AD L+ NIDG+I +NTT Sbjct: 402 NNSHMMKDAKDNFLWFNTTKKKPLVFVKLAPDLNQEQKKEIADVLLETNIDGMIISNTTT 461 Query: 250 DRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIA 309 + ++ +N GG+SG L+ ST+ I + N ++PII GGI S + A EKI Sbjct: 462 QINDIKSFENKK--GGVSGAKLKDISTKFICEMYNYTNKQIPIIASGGIFSGLDALEKIE 519 Query: 310 AGASLVQIYSGFIFKGPPLIKEIVTHI 336 AGAS+ Q+YS +F G +I + Sbjct: 520 AGASVCQLYSCLVFNGMKSAVQIKREL 546 >UniRef50_Q5KK62 Dihydroorotate dehydrogenase, mitochondrial, putative n=3 Tax=Agaricomycotina RepID=Q5KK62_CRYNE Length = 591 Score = 311 bits (796), Expect = 3e-83, Method: Composition-based stats. Identities = 134/376 (35%), Positives = 187/376 (49%), Gaps = 44/376 (11%) Query: 2 YYPFVRKALFQL----------DPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMG 51 YY R L + DPE+ H+ + L + G Sbjct: 52 YYYDSRSLLHEHVAMPLMRLVADPEQGHKLAVRVLAWDKWARPRDM-GVDGAELQAELFG 110 Query: 52 LTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLIN 111 + KNP+G+AAG DKD E ID L +GFG +E+G+VTP PQPGN KPR FRL + + IN Sbjct: 111 MHLKNPVGIAAGFDKDAEAIDGLFDLGFGYVEVGSVTPEPQPGNPKPRFFRLEEDDACIN 170 Query: 112 RMGFNNLGVDN-----------------------LVENV-------KKAHYDGVLGINIG 141 R GFN+LG + L N+ + +L +N+G Sbjct: 171 RYGFNSLGHGHALARLRLRLAKFAQDHPSLFPSPLPANLVPPAGLPRSLRAGQLLAVNLG 230 Query: 142 KNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQ 201 KNK + DDY+ + + +A + IN+SSPNTPGLR LQ + L+ LL + ++ Sbjct: 231 KNKASDP-DSNDDYVRGVRTLGPFADVVVINVSSPNTPGLRALQGKQQLERLLNDVVEER 289 Query: 202 NDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQ-GMKNC 260 N + A IAVK+A DLSE+EL VA ++ ++GVI +NTT+ R + N Sbjct: 290 NKI-AQGTGLPKIAVKVASDLSEDELADVASAVRSSGVEGVIVSNTTIRRKELNLVSGNQ 348 Query: 261 DQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSG 320 DQ GGLSG+PL + ++ L L +PIIG GGI S A AGAS+VQ+Y+ Sbjct: 349 DQIGGLSGKPLFPYALNALKTLRPLLPPSIPIIGCGGISSGSDALTMANAGASIVQVYTS 408 Query: 321 FIFKGPPLIKEIVTHI 336 F F+G + I I Sbjct: 409 FGFRGVGTPRLIKDEI 424 >UniRef50_C0W1V7 Possible dihydroorotate oxidase n=1 Tax=Actinomyces coleocanis DSM 15436 RepID=C0W1V7_9ACTO Length = 341 Score = 309 bits (793), Expect = 7e-83, Method: Composition-based stats. Identities = 125/353 (35%), Positives = 181/353 (51%), Gaps = 33/353 (9%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPF------------EALVRQKVPAKPVN 48 MY + DPE AH L P + + P Sbjct: 1 MYRWLFDNLITHSDPETAHNLVMNALTVAGSNPVSRAAIRATFNPTDTSLEPNASFLPKR 60 Query: 49 CMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEG 108 G LGLAAG+DK+ E I A A+GFG IEIGT+TP+ QPGN +PRL+RL + Sbjct: 61 VQGR-----LGLAAGMDKNAEAIHAFSALGFGFIEIGTITPKGQPGNPQPRLWRLPETRE 115 Query: 109 LINRMGFNNLGVDNLVENVKKAH-----YDGVLGINIGKNKDTPVEQGKDDYLICMEKIY 163 + N+MGFNN GVD + + K V+G NIGKNK T ++ +DY IC + Sbjct: 116 IRNQMGFNNHGVDAALLKLTKLRSTEAGRKIVVGSNIGKNKITSNDEALNDYEICASTLA 175 Query: 164 AYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLS 223 + ++ IN+SSPNTPGLR LQ E+L + ++ Q + V + +KIAPDL+ Sbjct: 176 PLSDFLVINVSSPNTPGLRDLQTVESLRPI---VETTQESANNAAQRDVSVFIKIAPDLA 232 Query: 224 EEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLS 283 +E+++ VAD + + GV+A NTT+ K+ ++GG+SG L + +I+ L Sbjct: 233 DEDILAVADLVNETGLTGVVAANTTI--------KHSYESGGISGPRLLNRGLDIVANLR 284 Query: 284 LELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 EL+ IIGVGGI + A + AGA L++ + FI++GP I + Sbjct: 285 KELDYDKTIIGVGGISTPDDAISYLDAGADLLEALTAFIYEGPAFPGRINRAV 337 >UniRef50_B7G8S8 Predicted protein n=2 Tax=Bacillariophyta RepID=B7G8S8_PHATR Length = 456 Score = 309 bits (792), Expect = 9e-83, Method: Composition-based stats. Identities = 138/382 (36%), Positives = 195/382 (51%), Gaps = 72/382 (18%) Query: 1 MYYPFVRKALFQ-LDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLG 59 + V + + LDPE AH + F ++ + G TF NP+G Sbjct: 46 LVDHIVTPTMRRILDPETAHHAGIFFAEQGLSPRFRPSALEQRCVVSNSVFGKTFPNPIG 105 Query: 60 LAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLG 119 LAAG DKDGE + + +GFG +EIGTVTP+ QPGN KPR+FRLV+ G+INR GFN+ G Sbjct: 106 LAAGFDKDGEVVQEMLDLGFGFVEIGTVTPQAQPGNPKPRMFRLVEDLGIINRYGFNSQG 165 Query: 120 VDNLVENVK-------------------------KAHYDGVLGINIGKNKDTPVEQGKDD 154 + +N+K H G++G+NIGKNK++ D Sbjct: 166 ASTVEKNLKSFRSPQPIDSAKLSWPRYIWNFLYPPRHQSGLVGVNIGKNKNSL--DAIGD 223 Query: 155 YLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPI 214 Y+ + ++ + A Y+ +NISSPNT GLR LQ +L Sbjct: 224 YVCNIRQLSSLADYMVLNISSPNTAGLRDLQQANSLR----------------------- 260 Query: 215 AVKI--------------------APDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLV 254 V + APDL++EEL Q+A+ + IDG+I TNTT R Sbjct: 261 -VLLTTCLTTRNEMTHRVPLLVKLAPDLTDEELDQIANVCLEVGIDGIIITNTTNHRPAD 319 Query: 255 QGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASL 314 K+ + GGLSG+P++ +STE IRRL +G++PIIGVGG+ S A EK+ AGASL Sbjct: 320 LLSKHRGEIGGLSGKPVKDQSTECIRRLFRLTDGKIPIIGVGGVGSGHDAYEKLKAGASL 379 Query: 315 VQIYSGFIFKGPPLIKEIVTHI 336 VQ+YS +++GP +I I + Sbjct: 380 VQVYSMMVYQGPGVISRIRHDL 401 >UniRef50_C6IFT5 Dihydroorotate dehydrogenase 2 n=7 Tax=Bacteroides RepID=C6IFT5_9BACE Length = 332 Score = 308 bits (790), Expect = 1e-82, Method: Composition-based stats. Identities = 122/343 (35%), Positives = 176/343 (51%), Gaps = 20/343 (5%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGT-PFEALVRQKVPAK-PVNCMGLTFKNPL 58 MY VR LF +DPE+ H L+ P A VR P + L FKN + Sbjct: 1 MYNLIVRPLLFLIDPEKVHRMLLNWLKIYRYLLPVRACVRGHYQVDEPFSYGSLRFKNRI 60 Query: 59 GLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNL 118 GL+AG DK+ E D L GFG +E+GTVTP QPGN PR+FRLV+ E LI+R GFNN Sbjct: 61 GLSAGFDKNAETFDELADFGFGFLEVGTVTPDYQPGNPSPRIFRLVEDESLISRTGFNNC 120 Query: 119 GVDNLVENVKK-AHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPN 177 GVD +E+++K + LG+NI KN + EQ D+ + ++Y Y +N S Sbjct: 121 GVDVALEHIRKYRKHSYRLGVNINKNPLSAGEQIIKDFELVFTRLYESVDYFTLNWGS-- 178 Query: 178 TPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRH 237 E+ +L + +K I +K+ D+ E+ L V ++ Sbjct: 179 -------IDKESFAKVL----ENLTTFRQAVNKRCSIFIKLPADIDEKALDLVISLAYKY 227 Query: 238 NIDGVIATNTTLDRSLVQGMKNCD----QTGGLSGRPLQLKSTEIIRRLSLELNGRLPII 293 +I+G IAT T+DRS + K GG+SGR + KS +++R LS + II Sbjct: 228 SIEGFIATGPTMDRSELHHTKTKQLEKIGNGGVSGRGIGKKSQKVVRYLSGHTDHHFLII 287 Query: 294 GVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 G GGI + A + I+ GA ++QIYS FI+ GP ++ +I + Sbjct: 288 GAGGIMTAEDAADMISQGADMIQIYSAFIYSGPSVVHKIGKKL 330 >UniRef50_A9F3A8 PyrD protein n=1 Tax=Sorangium cellulosum 'So ce 56' RepID=A9F3A8_SORC5 Length = 407 Score = 306 bits (783), Expect = 1e-81, Method: Composition-based stats. Identities = 136/350 (38%), Positives = 182/350 (52%), Gaps = 19/350 (5%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRIT-GTPFEALVR----QKVPAKPVNCMGLTFKN 56 Y VR LF L P AHE L I P ALV + V MGL F + Sbjct: 30 MYRLVRPLLFALPPSLAHELGMLALAPIEHAAPLRALVHARLAPRDGRIAVRTMGLDFPS 89 Query: 57 PLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFN 116 PLG+A G DKD AL A+GFG +E+GTVT +PQ N P LFRL LINR+GF Sbjct: 90 PLGVAGGFDKDARRARALAALGFGFVELGTVTAQPQAANPPPNLFRLPADRALINRLGFP 149 Query: 117 NLGVDNLVENV----KKAHYDGVLGINIGKNKDT---PVEQGKDDYLICMEKIYAYAGYI 169 N G + E + A +GI+IGK++ P+E DDYL + A ++ Sbjct: 150 NQGAARVTERLLGRGGTAAVGVPVGISIGKSRVAPLDPIEPAIDDYLASFREARRAADFV 209 Query: 170 AINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQ 229 IN+SSPNT LR +Q LL+AI + +P+ +K+APDL +EEL Sbjct: 210 VINVSSPNTKDLRAMQGPAIARALLSAIARE----NRAAGAPLPLLIKVAPDLGDEELEA 265 Query: 230 VADSLVRHNIDGVIATNTTLDRSLVQGMKN---CDQTGGLSGRPLQLKSTEIIRRLSLEL 286 + + + GVIATNTT+ R + GGLSG PL+ +S ++RR+ L Sbjct: 266 LLAVVEEVGLAGVIATNTTVRRDGLATSPADVEAMGAGGLSGPPLRQRSLAMVRRIRARL 325 Query: 287 NGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + +IG GGI+S A +++ AGA LVQIY+GFI+ GP L EI + Sbjct: 326 GSNVTVIGAGGIESAEHAMDQLQAGADLVQIYTGFIYGGPLLPAEIARGL 375 >UniRef50_C7NF21 Dihydroorotate oxidase A n=1 Tax=Kytococcus sedentarius DSM 20547 RepID=C7NF21_KYTSD Length = 385 Score = 304 bits (780), Expect = 2e-81, Method: Composition-based stats. Identities = 131/353 (37%), Positives = 187/353 (52%), Gaps = 22/353 (6%) Query: 2 YYPFVRKALFQL---DPERAHEFTFQQLRRITGTP-----FEALVRQKVPAKP----VNC 49 Y R LF+L D E AH T Q P A P +P V C Sbjct: 33 YEHLARPVLFRLGGGDAETAHHTTLQGAAAAARVPGLLHLVAAATGGLAPGQPAGGRVVC 92 Query: 50 MGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGL 109 G+ F + +GLAAG+DKDG + A+G G +E+GTVTPRPQ GN +PR+ RL + + Sbjct: 93 AGVAFGHRVGLAAGVDKDGTALLTWQALGLGHVELGTVTPRPQHGNPRPRVHRLRASRAV 152 Query: 110 INRMGFNNLGVDNLVENVKKAHYDG---VLGINIGKNKDTPVEQGKDDYLICMEKIYAYA 166 +N MGF N GV+ V ++ A +G +G++IGKNKDTP+ + +DY C+ Sbjct: 153 LNAMGFPNAGVEAAVHRLRVARDEGLTIPVGLSIGKNKDTPLARALEDYAACVRVAAGLP 212 Query: 167 GYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHH-KYVPIAVKIAPDLSEE 225 Y+A+NISSPNTPGLR L E L LL + + + VP+ K+APD+ + Sbjct: 213 DYLAVNISSPNTPGLRGLADPEPLRALLAGVVAAERERADAAGTPPVPVLCKVAPDMDDA 272 Query: 226 ELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNC----DQTGGLSGRPLQLKSTEIIRR 281 L + G+IATNTTL R + ++ GG+SG PL ++ E++R Sbjct: 273 ALHAAVGIAQEEGVAGIIATNTTLRRDGLTAEDRAWVGPERPGGVSGAPLTDRAREVVRL 332 Query: 282 LSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVT 334 + + LP++GVGG+ + E + AGA LVQ+Y+GFI+ GP L+ I Sbjct: 333 VRAGCD--LPVVGVGGVMTPQDGVELVRAGADLVQVYTGFIYAGPALVAGIAA 383 >UniRef50_B5CXJ8 Putative uncharacterized protein n=3 Tax=Bacteroides RepID=B5CXJ8_9BACE Length = 349 Score = 302 bits (773), Expect = 2e-80, Method: Composition-based stats. Identities = 119/344 (34%), Positives = 175/344 (50%), Gaps = 23/344 (6%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQ---KVPAKPVNCMGLTFKNP 57 MY +R LF++D E+ H L P + + + A P LTF N Sbjct: 21 MYKSILRPWLFRMDAEKIHGQIVALLHVYRHFPPVKCLLRVFYRPKATPFQWRNLTFANR 80 Query: 58 LGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNN 117 +GL+AG DK+ C D L +GFG +E+GTVTP GN PR+FRL + L++R GFNN Sbjct: 81 VGLSAGFDKEANCFDELSDLGFGFLEVGTVTPEKVAGNPFPRIFRLPEDHALVSRTGFNN 140 Query: 118 LGVDNLVENVKKAHY-DGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSP 176 G + +++N+++ +LG+NI N T E+ D E AYA Y IN S Sbjct: 141 PGKEVVLKNLQRKREGKYILGVNINTNTPTDAERAVTDITDLYETFSAYADYYTINWGS- 199 Query: 177 NTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVR 236 E L D+LTA+++ + P+ +K+ D+ E+L V + Sbjct: 200 --------MTPEILADVLTALESYKQRFHR------PVFLKLPADVPAEKLDTVIEFAKV 245 Query: 237 HNIDGVIATNTTLDRSLVQGMKNCD----QTGGLSGRPLQLKSTEIIRRLSLELNGRLPI 292 H+IDG IAT T DRSL+ + GG+SG P+ KS E+++ LS + + Sbjct: 246 HHIDGFIATGPTQDRSLLIHSAQTEVERVGAGGISGLPVIHKSLEVMKHLSAHAPKDMLL 305 Query: 293 IGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 IG GG+ + A+ AGA LVQ+YS FI++GP ++K I I Sbjct: 306 IGAGGVMTPFEAKAMRNAGAHLVQVYSAFIYEGPGVVKRIAEKI 349 >UniRef50_D0IRU1 Dihydroorotate dehydrogenase n=1 Tax=Helicobacter pylori 51 RepID=D0IRU1_HELP1 Length = 330 Score = 301 bits (770), Expect = 3e-80, Method: Composition-based stats. Identities = 121/315 (38%), Positives = 170/315 (53%), Gaps = 18/315 (5%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPF-----EALVRQKVPAKPVNCMGLTFK 55 M Y ++K LF LD E AHE + L+ ++ +PF ++ K P +GL F Sbjct: 1 MLYSLLKKYLFSLDAEYAHEKVCKILKVLSSSPFLCGLIDSQWGYKNPKLENEILGLHFP 60 Query: 56 NPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGF 115 NPLGLAAG DK+ + AL A GFG +E GT+T Q GN++PRLFR ++ E L N MGF Sbjct: 61 NPLGLAAGFDKNISMLRALIAFGFGYLEAGTLTNAAQSGNERPRLFRHIEEESLQNAMGF 120 Query: 116 NNLGVDNLVENVKK-AHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINIS 174 NN G + + A Y +GIN+GKNK +DY + K Y N+S Sbjct: 121 NNHGAVLGARSFNRFAPYKTPIGINLGKNKHIEQAHALEDYKAVLNKCLNIGDYYTFNLS 180 Query: 175 SPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSL 234 SPNTP LR LQ +++L K + P+ +KIAPDL +++++V +S Sbjct: 181 SPNTPNLRDLQNKAFVNELFCMAKEMT---------HKPLFLKIAPDLEIDDMLEVVNSA 231 Query: 235 VRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIG 294 + G+IATNTT+D+SLV K + GGLSG+ L KS EI + L+ + ++ Sbjct: 232 IEAGAHGIIATNTTIDKSLVFAPK---EMGGLSGKCLTKKSREIFKELAKAFFNKSVLVS 288 Query: 295 VGGIDSVIAAREKIA 309 VGGI A E+I Sbjct: 289 VGGISDAKDAYERIK 303 >UniRef50_C2BWU0 Possible dihydroorotate oxidase n=3 Tax=Mobiluncus RepID=C2BWU0_9ACTO Length = 348 Score = 299 bits (766), Expect = 9e-80, Method: Composition-based stats. Identities = 130/356 (36%), Positives = 183/356 (51%), Gaps = 31/356 (8%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPF------------EALVRQKVPAKPVN 48 MY R +LD E H L E +P + Sbjct: 1 MYKFVFRHLFVKLDAEWVHRRAIDWLEFWGRFGLTRQVAARIVHRGEPTFTWPLPRPNFD 60 Query: 49 CM--GLTFKN--PLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLV 104 G F+ PLGLAAG+DK+ I A+GFG +EIGT+TP PQPGND+PRL+R+ Sbjct: 61 SAPAGTKFRTYGPLGLAAGMDKEARAIAMWDALGFGFMEIGTITPLPQPGNDRPRLWRIP 120 Query: 105 DAEGLINRMGFNNLG----VDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICME 160 L N MGFNN G L + ++G NIGKNK TP E+ DY Sbjct: 121 QQRALRNAMGFNNEGARAAARRLRRWRAEYGERIIIGANIGKNKVTPPEKAPADYRKVTR 180 Query: 161 KIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAP 220 + A ++ IN+SSPNTPGLR LQ A+ LL +K Q +L++ +P+ VKIAP Sbjct: 181 VLAALVDFLVINVSSPNTPGLRDLQ---AVSSLLPIVKAVQRELESQGLSELPVFVKIAP 237 Query: 221 DLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIR 280 DL +E++ VA + + GV+ATNTT+ K+ GG+SG PL+ ++ E+++ Sbjct: 238 DLVDEDIAAVAQLTMDEGLTGVVATNTTI--------KHDLGAGGMSGEPLRNRALEVVK 289 Query: 281 RLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 L L+ IIGVGGI + AR +AAGA+L++ +S FI++GP + + Sbjct: 290 LLREHLSPEKTIIGVGGITTPEDARAMLAAGANLIEGFSAFIYEGPAWPAHLNREL 345 >UniRef50_C5K5A0 Dihydroorotate dehydrogenase, putative n=2 Tax=Perkinsus marinus ATCC 50983 RepID=C5K5A0_9ALVE Length = 471 Score = 299 bits (765), Expect = 1e-79, Method: Composition-based stats. Identities = 116/395 (29%), Positives = 178/395 (45%), Gaps = 63/395 (15%) Query: 1 MYYPFVRKALFQL---DPERAHEFTFQQLRRITGT------------------------- 32 +Y V LF L DPE AH Sbjct: 56 LYRGLVVPILFPLTASDPEVAHRMAIMGGAVYGRIVFFFHRFWNCLNVYNERVMDRIATI 115 Query: 33 --------PFEALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAM--GFGSI 82 P A+V V G+ F P+GLAAG DK+GE + L + G G Sbjct: 116 LLDGDSRRPACAVVSDDVDPLKQVLFGVEFPRPVGLAAGFDKNGELLHLLTSSTLGNGFA 175 Query: 83 EIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKK-------AHYDGV 135 EIG+V+ P PGN +PR+FRL +INRMG NN G L E ++ + Sbjct: 176 EIGSVSKEPWPGNPRPRMFRLARDGAVINRMGLNNRGAAALREKLRSMSTLLNGTRHTPP 235 Query: 136 LGINIGKNKDTPVEQ--GKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDL 193 +G++I K +E D + +++ YA YI +NIS PNT +T + EAL+ L Sbjct: 236 IGVSITKTPSPTIENDAAIADIVASFDEVAPYAAYIDVNISCPNTAEGKTFEDLEALEKL 295 Query: 194 LTAIKNKQNDLQAMHHKYVPIAVKIAP------DLSEEELIQVADSLVRHNIDGVIATNT 247 L A+ + D ++ P+ VK++P D E + ++ V +DG + NT Sbjct: 296 LGALLTWRRD----NYPDKPVLVKLSPPPAEADDTYYEGVSRMVRKAVELGVDGFVMINT 351 Query: 248 TLDRSLVQ------GMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSV 301 DR G N + GG+SG+P++ ++ ++R + G++PIIG GG+ + Sbjct: 352 IADRGDDLNLDRSVGDSNHGEKGGISGKPVRQRAINLVRHVYKVTAGKVPIIGCGGVFTA 411 Query: 302 IAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 A I GASL+Q+Y+G I++GP + ++I + Sbjct: 412 QDAYRLIRNGASLIQVYTGMIYEGPWVFRDINCGL 446 >UniRef50_D1CE91 Dihydroorotate dehydrogenase n=1 Tax=Thermobaculum terrenum ATCC BAA-798 RepID=D1CE91_THET1 Length = 376 Score = 298 bits (763), Expect = 2e-79, Method: Composition-based stats. Identities = 127/345 (36%), Positives = 182/345 (52%), Gaps = 19/345 (5%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEA---------LVRQKVPAKPVNCMG 51 +Y V L +LD E HE L + P R P V+ G Sbjct: 5 IYKHLVLPLLDRLDSETWHERVRHGLHTVEQVPLGPEFLEILAWKGRRVVDPRLKVSLAG 64 Query: 52 LTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLIN 111 + +NPL + AG DK G I AL A+GF S+E+GTVTPRPQPGN +PR F ++ + +IN Sbjct: 65 VQLENPLIVGAGWDKSGISIRALYALGFASVEVGTVTPRPQPGNPRPRQF-VLSSGVVIN 123 Query: 112 RMGFNNLGVDNLVENVKKAHYD-GVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIA 170 R+GFNN G D + N++ D +GI+IGKNKD P ++ Y K+Y Y Y Sbjct: 124 RLGFNNPGADAVAANLESYKSDNIPVGISIGKNKDDPEDRAPLAYAEVARKLYPYGSYFV 183 Query: 171 INISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQV 230 IN+SSPNTPGLR+LQ EAL + ++ + + + P+ +KIAP+LS +E+ ++ Sbjct: 184 INVSSPNTPGLRSLQRKEALLSIAQSVLDVMD----SYGARKPLFIKIAPELSYQEVDEI 239 Query: 231 ADSLVRHNIDGVIATNTT--LDRSLVQGMKNCDQTGGLSG--RPLQLKSTEIIRRLSLEL 286 D +++ + GV+ATNT D G Q GGLSG + ST + + + Sbjct: 240 LDVVLQLGLAGVVATNTVALGDVKARYGEGWRLQPGGLSGDDEVFRHMSTSKVAYIYSQT 299 Query: 287 NGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKE 331 G + IIGVGG+ A EKI AGA+ VQ+ + +G + Sbjct: 300 KGSIDIIGVGGVKDAHTALEKILAGATAVQVVTAIRSEGLAVAAR 344 >UniRef50_Q6MPX3 PyrD protein n=1 Tax=Bdellovibrio bacteriovorus RepID=Q6MPX3_BDEBA Length = 327 Score = 294 bits (754), Expect = 2e-78, Method: Composition-based stats. Identities = 113/336 (33%), Positives = 170/336 (50%), Gaps = 22/336 (6%) Query: 6 VRKALFQLDPERAHEFTFQQLRRITGTPFEALV--RQKVPAKPVNCMGLTFKNPLGLAAG 63 +R L L P+ AH+ + L P +L+ R+ K GL F NP+G+A G Sbjct: 1 MRPWL-LLPPQWAHDLSSLGL------PLYSLIHGRKTPHWKSFTWRGLEFANPMGIAGG 53 Query: 64 LDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNL 123 +DK+ E + A+G G +E+GT+TPR Q N + R ++ + + N+MGF + G D + Sbjct: 54 VDKNAEHLKEWWALGCGFVEVGTITPRAQTPNPGKIMDRDLELQAMWNKMGFPSDGGDEV 113 Query: 124 VENVKK--AHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGL 181 N+ +Y + +NIGKN+ TP DYL +++ +A +NISSPNT GL Sbjct: 114 FHNLASYAPNYRTPIFVNIGKNRHTPNNDAVADYLTLVDQFRPFADAFVVNISSPNTAGL 173 Query: 182 RTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDG 241 R LQ E L L+ I + + H + P+ VK++PD+ EE L + + +DG Sbjct: 174 RDLQKKENLRALIGPIVD-----RVSHFEPTPVLVKLSPDMGEEGLAEAVSNCQELGVDG 228 Query: 242 VIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGR---LPIIGVGGI 298 + TNTTL R GGLSG PL+ S ++ L + L ++ VGGI Sbjct: 229 FVLTNTTLSRPAGCHFPA---EGGLSGAPLKQLSQRALQIAVQTLGKKREGLLLVSVGGI 285 Query: 299 DSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVT 334 S E++ GA LVQIYS +F GP ++ Sbjct: 286 MSPEDVFERLQMGADLVQIYSALVFHGPGFFHDVAR 321 >UniRef50_D1ZM19 Whole genome shotgun sequence assembly, scaffold_58 n=1 Tax=Sordaria macrospora RepID=D1ZM19_SORMA Length = 753 Score = 290 bits (744), Expect = 4e-77, Method: Composition-based stats. Identities = 113/384 (29%), Positives = 176/384 (45%), Gaps = 63/384 (16%) Query: 12 QLDPERAHEFTFQQLRRITGTPFEALVRQKVPA-----KPVNCMGLTFKNPLGLAAGLDK 66 D E AH L+ + +R++VP VN G NP+G++AGLDK Sbjct: 365 YPDAEEAHHVGTAALKGLYEVGLH--IRERVPEYPNGPLSVNVFGKQLLNPIGISAGLDK 422 Query: 67 DGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVEN 126 D E D L A+G G +E+G TP PQ GN KPR+FR+ +GLINR G N+ G D + Sbjct: 423 DAEIPDPLFALGAGVVEVGGCTPFPQEGNPKPRVFRIPTVDGLINRYGLNSRGADAMATR 482 Query: 127 VKKA-----------------------------HYDGVLGINIGKNKDTPVEQG---KDD 154 +++ H +L + I KNK T + D Sbjct: 483 LRERLRKFARSVGLSENQVLNEEGTDDIPPGSLHPGRLLCVQIAKNKKTDEKDVNSVIRD 542 Query: 155 YLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPI 214 Y+ C++K+ YA + +N+SSPNTPGLR LQ E L LL+A+ + + + + Sbjct: 543 YVYCVDKLAPYADVLVVNVSSPNTPGLRDLQATEPLTKLLSAVVDAAQATKRKNKPR--V 600 Query: 215 AVKIAPDLSEE-ELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNC---------DQTG 264 VK++PD + ++ V +++ +DGVI NTT R+ + + G Sbjct: 601 MVKVSPDEDDNTQMEGVVEAVWNSGVDGVIVGNTTKRRTGIIPQGVKLIGDEPEVLHEEG 660 Query: 265 GLSGRPLQLKSTEIIRRLSLELNG------------RLPIIGVGGIDSVIAAREKIAAGA 312 G SG L ++ ++ R L+G + + GGI + A + + AGA Sbjct: 661 GFSGPALFDRTVSLVGRYRKMLDGYALKNEADKSAAQKVLFATGGITNGEQALKVLNAGA 720 Query: 313 SLVQIYSGFIFKGPPLIKEIVTHI 336 S+ +Y+G ++ G I I T + Sbjct: 721 SVAMVYTGMVYGGSGTITRIKTEM 744 >UniRef50_A7BDH3 Putative uncharacterized protein n=1 Tax=Actinomyces odontolyticus ATCC 17982 RepID=A7BDH3_9ACTO Length = 312 Score = 288 bits (738), Expect = 2e-76, Method: Composition-based stats. Identities = 115/298 (38%), Positives = 169/298 (56%), Gaps = 15/298 (5%) Query: 44 AKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRL 103 P+ + LGLAAG+DKD E + + A+G+ +EIGTVTPRPQPGND PRL+RL Sbjct: 22 EVPLTLGERRLPSRLGLAAGMDKDAEAVLGMCALGYAFVEIGTVTPRPQPGNDAPRLWRL 81 Query: 104 VDAEGLINRMGFNNLGVDNLVENVKKAH-----YDGVLGINIGKNKDTPVEQGKDDYLIC 158 ++ GL NRMGFNN G D E +++ ++G NIGKNK T DY C Sbjct: 82 MEERGLRNRMGFNNAGADAAAEKLRELRSTPAGRATIVGANIGKNKVTSEADAPADYEYC 141 Query: 159 MEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKI 218 + + ++ +N+SSPNTPGLR LQ + L +L A + + +P+ VKI Sbjct: 142 ARTLAHWVDFVVVNVSSPNTPGLRDLQSVDHLRPILQAARRGCE--AGAPDRTMPLFVKI 199 Query: 219 APDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEI 278 APDL++E+++ V + + GV+ATNTT++ + GG+SG PL ++ E+ Sbjct: 200 APDLADEDIVAVVELTKELGLAGVVATNTTIN--------HNLGEGGVSGAPLLPRALEV 251 Query: 279 IRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + ++ L+ +IG GGI S A I+AGA LV+ +S FIF+GP E+ + Sbjct: 252 VSLVARHLDDDQILIGTGGISSPEDALRMISAGADLVEAFSAFIFEGPSWPGEVSRAL 309 >UniRef50_B2B417 Predicted CDS Pa_6_7920 n=3 Tax=Sordariomycetes RepID=B2B417_PODAN Length = 482 Score = 288 bits (737), Expect = 2e-76, Method: Composition-based stats. Identities = 118/394 (29%), Positives = 180/394 (45%), Gaps = 64/394 (16%) Query: 4 PFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPA------KPVNCMGLTFKNP 57 P V + LF D E AH L+ + R + VN G+ NP Sbjct: 81 PRVIRVLF-PDAEDAHHAGTAALKALYSVGLHPRERVQDGDATGAKPLAVNVFGVELSNP 139 Query: 58 LGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNN 117 +G++AGLDKD E D L A+G G +E+G +TP PQ GN KPR+FR+V +GLINR G N+ Sbjct: 140 IGISAGLDKDAEIPDPLFALGAGVVEVGGITPLPQEGNPKPRVFRVVSTDGLINRYGLNS 199 Query: 118 LGVDNLVENVKKA---------------------------HYDGVLGINIGKNKDT---P 147 G D + ++++ +L + I KNK T Sbjct: 200 KGADAVAAHLRERLRTFARSIGFTEKEMLDGEAGVPVGSLKDGRLLCVQIAKNKKTDEKD 259 Query: 148 VEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAM 207 VE K DY+ C+ ++ YA + +N+SSPNTPGLR LQ L LL+A+ + + Sbjct: 260 VEAVKKDYVTCVNRLAPYADVLVVNVSSPNTPGLRDLQATGPLTALLSAVVEEAQKTKRK 319 Query: 208 HHKYVPIAVKIAPDLSEE-ELIQVADSLVRHNIDGVIATNTTLDRSLV---------QGM 257 + VK++PD ++ ++ V ++ +DGVI NTT R+ + Q Sbjct: 320 VKPR--VMVKVSPDEDDDSQMEGVVQAVWMSGVDGVIVGNTTKKRTGLVPKGVRLTSQEQ 377 Query: 258 KNCDQTGGLSGRPLQLKSTEIIRRLSLELN---------------GRLPIIGVGGIDSVI 302 KN + GG SG L ++ ++ R L+ + I GGI + Sbjct: 378 KNIMEDGGYSGPALFNQTLNLVGRYRKMLDSYSLKTEGLGDAFNKNQKVIFATGGITNGD 437 Query: 303 AAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 A + + AGAS+ +Y+G ++ G I I + Sbjct: 438 EALKVLNAGASVAMVYTGMVYGGSGTITRIKNEM 471 >UniRef50_A3ZNL9 Dihydroorotate dehydrogenase n=2 Tax=Planctomycetaceae RepID=A3ZNL9_9PLAN Length = 372 Score = 285 bits (730), Expect = 1e-75, Method: Composition-based stats. Identities = 97/354 (27%), Positives = 158/354 (44%), Gaps = 26/354 (7%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQK-----VPAKPVNCMGLTFK 55 +Y +R LF D E AH T R P + + N GLTF Sbjct: 3 LYRSILRPLLFHWDAETAHHATIAACRIAGAIPLAPQLMRAWYDFAASPLESNVAGLTFP 62 Query: 56 NPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGF 115 NP+GLAAG DK+G + L + GFG EIG+++ GN +PRLFRL ++ G Sbjct: 63 NPVGLAAGWDKNGHALRLLDSWGFGFAEIGSISAAASLGNRRPRLFRLPQDRAIVVNYGL 122 Query: 116 NNLGVDNLVENVKKAHYDGVLGINIGKNKDTPV------EQGKDDYLICMEKIYAYAGYI 169 N G + + + + K LG+N+ K P E+ DDY+ + ++ +A Y+ Sbjct: 123 PNDGAEVIAQRLAKHRIRRPLGVNLVKTNQGPDAAASSAERIVDDYVCSAQAVHRHASYL 182 Query: 170 AINISSPNTPGLRT-LQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELI 228 +N+S PN G + ++ LLTA+ P+ +K+AP+ E+ Sbjct: 183 TLNLSCPNAAGGKDFFAQPGSIRQLLTALLPL--------EIACPLFLKVAPNPDPAEIE 234 Query: 229 QVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQ-----TGGLSGRPLQLKSTEIIRRLS 283 ++ + N + ++ + Q G ++G+P+ S I + Sbjct: 235 RLLEECEPFAAVRGFLFNLPVGKAASLALTTPRQVWEKMPGAVAGQPVAALSNRCIAEMY 294 Query: 284 LELN-GRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + R IIG GG+ S A EK+ GASL+QIY+ +++GP ++ I + Sbjct: 295 QRMPRDRYVIIGGGGVFSAADAYEKMGLGASLIQIYTALVYEGPGVVGRINRGL 348 >UniRef50_UPI00016B255A dihydroorotate dehydrogenase 2 n=4 Tax=candidate division TM7 RepID=UPI00016B255A Length = 394 Score = 281 bits (720), Expect = 2e-74, Method: Composition-based stats. Identities = 100/354 (28%), Positives = 173/354 (48%), Gaps = 26/354 (7%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALV------RQKVPAKPVNCMGLTF 54 +Y ++K LF + P++AH R P L+ + N G+ F Sbjct: 23 LYKNVIKKFLFIIPPDKAHSILVSFARIYQSLPILPLITKFILTHRNNNRLKQNICGINF 82 Query: 55 KNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMG 114 NP+GL+AG DK+ E I + +GFG + G++T P+ GN +P +RL ++ ++ G Sbjct: 83 SNPVGLSAGFDKNIELIPTMSMVGFGYMTGGSITITPRAGNPRPWFYRLPKSKSIVVHAG 142 Query: 115 FNNLGVDNLVENVKK-----AHYDGVLGINI---GKNKDTPVEQGKDDYLICMEKI--YA 164 N G + +++N+K+ A+ L I+I +++D+ D M + Sbjct: 143 LANDGANIILQNIKRQYKKEANRKIPLFISIAVVARSQDSTEADIIKDVCEAMSLVSGSG 202 Query: 165 YAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSE 224 A + INIS PN + Y + LD+LL+ + D+ PI +K+ + Sbjct: 203 LAKAVEINISCPNIDDNQPFTYPDKLDNLLSQLDKINADM--------PIFIKMPNLVDF 254 Query: 225 EELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQT--GGLSGRPLQLKSTEIIRRL 282 + + + +H I+GV +N DRS + ++ GGLSG+P + +S ++I+ Sbjct: 255 VRFGLILEIISKHKINGVTISNLVKDRSNINLKDKLPESVKGGLSGKPCRDRSLDLIKFT 314 Query: 283 SLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + RL IIGVGGI + A KI AG+SLV + +G +F+GP ++ +I + Sbjct: 315 YEKYGDRLLIIGVGGIFNAEDAYLKIRAGSSLVALITGLMFEGPQMVGDINHGL 368 >UniRef50_Q2H299 Putative uncharacterized protein n=3 Tax=cellular organisms RepID=Q2H299_CHAGB Length = 596 Score = 280 bits (716), Expect = 6e-74, Method: Composition-based stats. Identities = 103/373 (27%), Positives = 168/373 (45%), Gaps = 43/373 (11%) Query: 4 PFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPA----------KPVNCMGLT 53 P + + LF D E AH L+ + R P V G T Sbjct: 218 PRLIRVLF-PDAEDAHHAGTAALKTLYPLGLHPRERPPFPEDAHPATGTNPLAVTVFGTT 276 Query: 54 FKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRM 113 NP+G++AGLDKD E D L A+G G +E+G TP PQ GN +PR+FR+ +GL+NR Sbjct: 277 LANPIGISAGLDKDAEIADPLFALGAGVVEVGGCTPLPQAGNPRPRVFRVPAVDGLVNRY 336 Query: 114 GFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGK------DDYLICMEKIYAYAG 167 G N+ G D + +++ G+ + + + + + + ++ YA Sbjct: 337 GLNSRGADAMAARLRERLRKFARGLGLSEREVLEAGEEEGGCADGESVAGEAARLAPYAD 396 Query: 168 YIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEE-E 226 + +N+SSPNTPGLR LQ E L LL A+ ++ + + VK++PD ++ + Sbjct: 397 VLVVNVSSPNTPGLRDLQAAEPLARLLGAVVDEAKRAKRKVKPR--VMVKVSPDEDDDTQ 454 Query: 227 LIQVADSLVRHNIDGVIATNTTLDRSLV---------QGMKNCDQTGGLSGRPLQLKSTE 277 + V ++ +DGVI NTT R+ + + K + GG SG + ++ Sbjct: 455 MDGVVQAVWMSGVDGVIVGNTTKRRTGLVKEGIKLTGREQKALVEDGGFSGPAMFDRTLS 514 Query: 278 IIRRLSLELN----------GRLP----IIGVGGIDSVIAAREKIAAGASLVQIYSGFIF 323 ++ R L+ P I GGI + A + + AGAS+ +Y+G ++ Sbjct: 515 LVGRYRKMLDSYSLKTSGVNDVFPTPKVIFATGGITNGDQALQVLNAGASVAMVYTGMVY 574 Query: 324 KGPPLIKEIVTHI 336 G I I + Sbjct: 575 GGSGTITRIKKEM 587 >UniRef50_C6A9A6 Dihydroorotate dehydrogenase 2 n=20 Tax=Bifidobacteriaceae RepID=C6A9A6_BIFLB Length = 386 Score = 276 bits (706), Expect = 8e-73, Method: Composition-based stats. Identities = 104/348 (29%), Positives = 158/348 (45%), Gaps = 22/348 (6%) Query: 2 YYPFVRK-ALFQLDPERAHEFTFQQLRRITGTPF-----EALVRQKVPAKPVNCMGLTFK 55 Y ++ +F P+ AH+ + + P ++ P N MG+ F Sbjct: 28 YKHVIKPDLVFNHTPDIAHDQMIRFCQITGKMPPLMWLCRTMLNYTDPILETNVMGINFA 87 Query: 56 NPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGF 115 NP GL+AGLDK+ + L GFG +G+ T RP GN +P RL + + ++ +G Sbjct: 88 NPFGLSAGLDKNCDMAAVLDHAGFGFETVGSTTSRPCAGNPRPWFHRLPEYDSMMVHVGL 147 Query: 116 NNLGVDNLVENVKKAHYDG---VLGINIGKNKDTPVEQ---GKDDYLICMEKIYAYAGYI 169 N G D ++E + A L ++I + D V G +DY I ME+ + Sbjct: 148 ANDGSDVVIERAEDAWRRTQSMQLSVSIARTNDDQVGDLNEGIEDYCISMERAAGRTAMV 207 Query: 170 AINISSPNTP-GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELI 228 +N+S PNT G + E LD L A+ + P VK+ + + Sbjct: 208 EVNVSCPNTTVGEPFTESAENLDKLFAALDRI--------ERPQPTLVKMPLNKPWPQFK 259 Query: 229 QVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNG 288 + D L HN+ GV N DR+ + + D GGLSG P + STE+IRR E Sbjct: 260 EFLDVLAAHNVQGVTIANLQKDRTGLDDIP-KDWLGGLSGGPCTVASTELIRRTYAEYGD 318 Query: 289 RLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 R I GVGG+ + A EKI AG+SL+ S +++GP I + + Sbjct: 319 RFAIAGVGGVFTPEQAYEKIRAGSSLIMFISSLMYRGPQQITVLKRGL 366 >UniRef50_A2QCB1 Catalytic activity: n=26 Tax=Leotiomyceta RepID=A2QCB1_ASPNC Length = 544 Score = 260 bits (665), Expect = 5e-68, Method: Composition-based stats. Identities = 109/416 (26%), Positives = 171/416 (41%), Gaps = 87/416 (20%) Query: 4 PFVRKALFQLDPERAHEFTFQQLR---RITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 P VR LF D E AH F L+ + P E A G T NP+G+ Sbjct: 129 PLVR-LLF-PDAEDAHHFGVDILKTLYKYGLNPRERGDPDSDGALLTEVFGYTLSNPIGI 186 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 + GLDK + D L +G +E+G TP PQ GN +PR+FRL + +INR G N+ G Sbjct: 187 SGGLDKHADIPDPLFELGPAIVEVGGTTPLPQDGNPRPRVFRLPSQKAMINRYGLNSKGA 246 Query: 121 DNLVENVKKAHYD--------------------------------GVLGINIGKNKDTP- 147 D++ +++ D +L + + KNK TP Sbjct: 247 DHMAAVLEQRVRDYAYAHGFGEHELAEQRVLNGEAGVPPGSLREGKLLAVQVAKNKLTPD 306 Query: 148 --VEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQ 205 +E K DY+ C++++ YA + +N+SSPNTPGLR LQ L +L A+ + Sbjct: 307 NDIEAIKRDYVYCVDRLAKYADILVVNVSSPNTPGLRDLQATAPLTAILKAVVGAAKSID 366 Query: 206 AMHHKYVPIAVKIAPDLS-EEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNC---- 260 + + VK++PD +E++ + D++ +DGVI NTT R Sbjct: 367 RKTKPF--VMVKVSPDEDADEQVSGICDAVWGSGVDGVIVGNTTNRRPEPLPKGFTLPSK 424 Query: 261 -----DQTGGLSGRPLQLKSTEIIRRLSLELN---------------------------- 287 +TGG SG L ++ ++ R L+ Sbjct: 425 EQDVLKETGGYSGPQLFDRTVALVARYRSLLDASAPAAAAVPKALEAAEPDVENVPPTVS 484 Query: 288 -------GRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 R I GG+ + AR+ + AGAS+ +Y+ + G + + + Sbjct: 485 EAVEGLPARKVIFASGGVTNGAQARKVLDAGASVAMMYTAITYGGLGTVTRVKEEM 540 >UniRef50_Q4N5X1 Dihydroorotate dehydrogenase, putative n=1 Tax=Theileria parva RepID=Q4N5X1_THEPA Length = 291 Score = 247 bits (630), Expect = 6e-64, Method: Composition-based stats. Identities = 111/331 (33%), Positives = 159/331 (48%), Gaps = 65/331 (19%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 +Y + LDPE +H+ + L ++ TP + + P N + NP+G+ Sbjct: 16 IYDGILYGLRKCLDPEESHKLSI-VLAKLGLTPVDYSI--DPPILYNNIKHIKIFNPIGM 72 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAG DK+ + + +GFG IE+GTV P PQPGN KPRLFRL + + LIN +GFN+LG+ Sbjct: 73 AAGYDKNCQVPLEILRLGFGFIEVGTVLPNPQPGNPKPRLFRLPNNKALINSLGFNSLGI 132 Query: 121 DNLVENVKKAH---------YDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAI 171 D VEN+K A D ++GI+IGKN + + D C+E+I Y+ Y+ I Sbjct: 133 DVAVENMKVARARQESDPLTRDSIIGISIGKNLN---GEILADVSHCIERIGLYSDYLCI 189 Query: 172 NISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVA 231 N+SSPNTP LR Q E L L+ KN DL+ V PD++++EL +A Sbjct: 190 NVSSPNTPNLRDNQRKEPLLKLVKTAKNALKDLET----RVSTENLTYPDVTDQELKDIA 245 Query: 232 DSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLP 291 D + H +DG++ TNTT Sbjct: 246 DIALEHGLDGLVLTNTT------------------------------------------- 262 Query: 292 IIGVGGIDSVIAAREKIAAGASLVQIYSGFI 322 GGI + A E I AGAS Q+ +G + Sbjct: 263 ---CGGISTAQDALEMIEAGASACQLLTGLV 290 >UniRef50_UPI00016B240E dihydroorotate dehydrogenase 2 n=1 Tax=candidate division TM7 single-cell isolate TM7c RepID=UPI00016B240E Length = 338 Score = 240 bits (613), Expect = 5e-62, Method: Composition-based stats. Identities = 92/317 (29%), Positives = 140/317 (44%), Gaps = 26/317 (8%) Query: 37 LVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGND 96 + + + G+ F+NP+GL+AG DK+ + + +GFG G+VT P+ GN Sbjct: 1 MWSFRDKSLQQEIDGVNFRNPIGLSAGFDKNVQLSPLMEDVGFGFASGGSVTLEPRKGNL 60 Query: 97 KPRLFRLVDAEGLINRMGFNNLGVDNL-----VENVKKAHYDGVLGINIGKNKDT----- 146 +P RL + ++ G N G++ + +K V+ + + NK T Sbjct: 61 RPWFHRLPKTKSVVVYAGMPNYGLEKIGNYVKANRIKIQSMPTVVSVAVVANKSTKDKLG 120 Query: 147 ---PVEQGKDDYLICMEKI--YAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQ 201 P E D + I A + INIS PN G + Y E L+ LL I Sbjct: 121 PKVPEEYIVKDVKKAVNYIIDNKLASIVEINISCPN-AGKESFIYPETLEILLKEIDTI- 178 Query: 202 NDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQ--GMKN 259 + +P +K+ + + +V+HNI GV N DR+ V+ Sbjct: 179 -------DRNIPFWIKMPHLYDINQFDSLLKVIVKHNIQGVTIANLVKDRTKVEIKDPLT 231 Query: 260 CDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYS 319 + GGLSG P + S E+IR +L I+GVGGI S A KI AGASLV + + Sbjct: 232 DEIRGGLSGEPTRKHSLELIRYAYKNYGNKLTIVGVGGIFSAEDAYAKIKAGASLVGLIT 291 Query: 320 GFIFKGPPLIKEIVTHI 336 G F+GP L+ + Sbjct: 292 GLFFEGPHLVGRANREL 308 >UniRef50_B2V726 Dihydroorotate dehydrogenase n=2 Tax=Aquificales RepID=PYRD_SULSY Length = 311 Score = 235 bits (601), Expect = 1e-60, Method: Composition-based stats. Identities = 79/305 (25%), Positives = 136/305 (44%), Gaps = 31/305 (10%) Query: 42 VPAKPVNCMGLTFKNPLGLAAGLDKDG-ECIDALGAMGFGSIEIGTVTPRPQPGNDKPRL 100 + GL FKNP+ A+G G E G+I + ++ +P+ GN R+ Sbjct: 1 MDKLKHTLFGLEFKNPVWTASGTFSYGLEVAKIYDLSLLGAIVVKGLSLKPRKGNMPERI 60 Query: 101 FRLVDAEGLINRMGFNNLGVDNLVENV--KKAHYDGVLGINIGKNKDTPVEQGKDDYLIC 158 G++N +G N GVD + K YD + N+ + +D+YL Sbjct: 61 VE--TPAGMLNSIGLQNPGVDYFINETLPKLKKYDTKIFANV-------FGEDEDEYLAV 111 Query: 159 MEKIYAYAGY--IAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPI 214 E++ G + +N+S PN G+ E L +L+ +K P+ Sbjct: 112 AERLDKADGVHGLELNVSCPNVKKGGIAFGTDPEVLYNLVYKMKKITKK---------PL 162 Query: 215 AVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLV---QGMKNCDQTGGLSGRPL 271 VK++P++S ++ AD+ V DG++ NT L ++ + TGGLSG + Sbjct: 163 LVKLSPNVS--NILDTADACVSAGADGLVLINTLLGVAIDVEREKPILSTITGGLSGPAM 220 Query: 272 QLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKE 331 + +I ++ + R+PIIGVGGI + A + I AGAS +Q+ + + P + Sbjct: 221 LPIAVRMIWQVYQKYGSRIPIIGVGGISNYKDALQHILAGASAIQVGTANFYD-PLSPLK 279 Query: 332 IVTHI 336 I+ + Sbjct: 280 IIEDL 284 >UniRef50_Q2IVE7 Dihydroorotate oxidase B, catalytic subunit n=1 Tax=Rhodopseudomonas palustris HaA2 RepID=Q2IVE7_RHOP2 Length = 348 Score = 235 bits (600), Expect = 2e-60, Method: Composition-based stats. Identities = 87/342 (25%), Positives = 143/342 (41%), Gaps = 26/342 (7%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRI---TGTPFEALVRQKVPAKPVNCMGLTFKNP 57 +Y + LF++ P+R+H LRR A +R P G+ NP Sbjct: 3 LYRDLLAPGLFRMSPDRSHAMAHAALRRAVPWRLLAAAATLRVDDPRLVTRFAGVELPNP 62 Query: 58 LGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNN 117 +GLAAG DKD E I AL +GFG + +G++ P P+ GN PRL R E + + MG + Sbjct: 63 VGLAAGFDKDAELIAALSCLGFGFVCVGSIMPEPRVGNPFPRLVRRRGTESIADSMGVPS 122 Query: 118 LGVDNLVENVKKA-HYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSP 176 G E +++ + NIG + G + + + + +++ P Sbjct: 123 KGRAYATERLRRLGPRAVPVIANIGGFSADTIAAGVIE-------VAPHVDLVELSLMCP 175 Query: 177 NTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSE--EELIQVADSL 234 N L GE D+ I + L + + I V++ D + + ++ + Sbjct: 176 NV-----LADGEVFDE----IGMLRGVLARLDGRAGSIVVRVPNDTTRLHDRFAELIEVC 226 Query: 235 VRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIG 294 + + G+ R G+ G L GR + + + R + GRL I G Sbjct: 227 IAAGVGGIKVG--GGRRIAEPGLGT--GAGTLHGREIFDTALMNVERAAGFARGRLAIKG 282 Query: 295 VGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 GGI S AGAS V +YS FI++G + ++I + Sbjct: 283 NGGISSAADVLAMRRAGASCVDLYSAFIYQGWTIARDINRAL 324 >UniRef50_C0QU30 Dihydroorotate dehydrogenase, catalytic subunit (Dihydroorotate oxidase) (Dhodehase) (Dhodase) (Dhod) n=3 Tax=Hydrogenothermaceae RepID=C0QU30_PERMH Length = 320 Score = 233 bits (595), Expect = 7e-60, Method: Composition-based stats. Identities = 73/303 (24%), Positives = 135/303 (44%), Gaps = 32/303 (10%) Query: 45 KPVNCMGLTFKNPLGLAAGLDKDG--ECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFR 102 G+ FKNP+ A+G G + G++ + ++ RP+ GN R+ Sbjct: 12 LSYELFGIKFKNPVWTASGCFSYGLEVAQNLYDISELGAVVVKGLSYRPREGNPPQRIVE 71 Query: 103 LVDAEGLINRMGFNNLGVDNLVENVKK--AHYDGVLGINIGKNKDTPVEQGKDDYLICME 160 G++N +G N GV+ ++N+ YD V+ N+ + +D+YL E Sbjct: 72 --TPCGMLNSIGLQNPGVEYFIKNILPQLREYDTVIVANV-------FGEDEDEYLKVAE 122 Query: 161 KI--YAYAGYIAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAV 216 + + +N+S PN G+ E L +L+ +K P+ V Sbjct: 123 VLNKADGVDLLELNVSCPNVKKGGIAFGSDPETLFNLVYRLKQVMEK---------PLLV 173 Query: 217 KIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLV---QGMKNCDQTGGLSGRPLQL 273 K++P++++ ++ A + V DG++ NT L ++ + +TGGLSG + Sbjct: 174 KLSPNITD--ILDTATASVEAGADGLVLINTLLGMAIDIDKEEPIIGMRTGGLSGPAILP 231 Query: 274 KSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIV 333 + +I ++ + +PIIGVGGI + A + I AGA VQI + + P +++ Sbjct: 232 VAVRMIYQVYEKYGSSVPIIGVGGITTAQDALQHILAGAVSVQIGTANFYD-PYSPLKVI 290 Query: 334 THI 336 + Sbjct: 291 KGL 293 >UniRef50_Q00YC9 Dihydroorotate dehydrogenase (ISS) (Fragment) n=1 Tax=Ostreococcus tauri RepID=Q00YC9_OSTTA Length = 369 Score = 229 bits (585), Expect = 1e-58, Method: Composition-based stats. Identities = 90/212 (42%), Positives = 130/212 (61%), Gaps = 3/212 (1%) Query: 126 NVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQ 185 ++ GVLG+N+GKNK TP DDY++ ++ I Y YI +N+SSPNTPGLR LQ Sbjct: 8 RAREDVPAGVLGVNLGKNKTTPEANAADDYVLGVDNIGEYGDYIVVNVSSPNTPGLRNLQ 67 Query: 186 YGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIAT 245 + L LL + + ++ A K P+ VKIAPDL++ E+ VA + +DGVI + Sbjct: 68 GRKHLSGLLRKVLSARDRNPATAKK--PVLVKIAPDLTDAEIKDVASVVKSEKVDGVIVS 125 Query: 246 NTTLDRSL-VQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAA 304 NTT+ R ++ K+ D+ GGLSG+PL ST ++ L G++P++G GG+ S A Sbjct: 126 NTTVARPEEIKAHKHGDEAGGLSGKPLMESSTRVLHELYRLTGGKIPLVGCGGVASGEDA 185 Query: 305 REKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 KI AGA+LVQ+Y+ F F GPPLI +I + Sbjct: 186 YAKIRAGATLVQLYTAFAFGGPPLILKIKREL 217 >UniRef50_B0TGQ8 Dihydroorotate dehydrogenase n=32 Tax=Bacteria RepID=PYRD_HELMI Length = 309 Score = 228 bits (582), Expect = 2e-58, Method: Composition-based stats. Identities = 68/302 (22%), Positives = 130/302 (43%), Gaps = 33/302 (10%) Query: 45 KPVNCMGLTFKNPLGLAAGLDKDG-ECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRL 103 VN GLT KNP+ A+G G E + G+I + T P+ GN PR+ Sbjct: 6 LQVNLGGLTMKNPVTTASGTFGFGLEFAPFIDLSRLGAIVVKGTTLEPREGNPTPRMAE- 64 Query: 104 VDAEGLINRMGFNNLGVDNLVENVKK--AHYDGVLGINIGKNKDTPVEQGKDDYLICMEK 161 G++N +G N GV+ + + D + +N+ N +DY Sbjct: 65 -TPAGMLNAIGLQNPGVEAFIRDYLPPLRQIDTPVIVNVSGN-------SVEDYGRLASI 116 Query: 162 I--YAYAGYIAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVK 217 + + +NIS PN G++ + + A++ + P+ VK Sbjct: 117 LDEADGVAALEVNISCPNVKEGGIQFGTLPASAAAVTRAVRE---------NTQKPVIVK 167 Query: 218 IAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLV---QGMKNCDQTGGLSGRPLQLK 274 ++P++++ + ++A ++V D + NT L + + + GGLSG ++ Sbjct: 168 LSPNVTD--ITEMARAVVDAGADALALINTLLGMDIDICTRRPVLANIFGGLSGPAIKPV 225 Query: 275 STEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVT 334 + +I ++ ++ +PI+G+GGI + A + AGA+ + + + F P +I+ Sbjct: 226 ALRMIYQVYRAVH--VPILGMGGIMNSQDAIAFMLAGATAIAVGTAN-FTNPRATMDILE 282 Query: 335 HI 336 I Sbjct: 283 GI 284 >UniRef50_A4IM35 Dihydroorotate dehydrogenase n=348 Tax=Bacteria RepID=PYRD_GEOTN Length = 313 Score = 227 bits (578), Expect = 5e-58, Method: Composition-based stats. Identities = 72/303 (23%), Positives = 128/303 (42%), Gaps = 33/303 (10%) Query: 44 AKPVNCMGLTFKNPLGLAAGLDKDG-ECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFR 102 V GL+ KNP+ A+G G E G+I I T P+ GN PR+ Sbjct: 3 RLAVELPGLSLKNPIMPASGCFGFGREYAQFYDLSVLGAIMIKATTKEPRFGNSTPRVAE 62 Query: 103 LVDAEGLINRMGFNNLGVDNLVENVKKA--HYDGVLGINIGKNKDTPVEQGKDDYLICME 160 G++N +G N G+D ++ +D + NI + ++Y+ Sbjct: 63 --TPSGMLNAIGLQNPGLDKVLAEELPWLEQFDVPIIANIAGST-------MEEYVEVAA 113 Query: 161 KI--YAYAGYIAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAV 216 I + +NIS PN G+ E +L +K VP+ V Sbjct: 114 AISKAPNVHALELNISCPNVKKGGIAFGTVPEVAAELTRLVKEV---------SAVPVYV 164 Query: 217 KIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKN---CDQTGGLSGRPLQL 273 K++P++++ ++ +A ++ + DG+ NT + + + TGGLSG ++ Sbjct: 165 KLSPNVTD--IVAMAKAIEQAGADGLTMINTLVGMRIDVKTGRPILANGTGGLSGPAVKP 222 Query: 274 KSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIV 333 + +I +S ++ +PIIG+GG+ + E AGAS V + + F P + I+ Sbjct: 223 IAVRMIYEVSQAVS--IPIIGMGGVQTAEDVLEFFYAGASAVAVGTAN-FIDPFVCPTII 279 Query: 334 THI 336 + Sbjct: 280 NEL 282 >UniRef50_A6L5H1 Dihydroorotate dehydrogenase n=7 Tax=Bacteroidales RepID=PYRD_BACV8 Length = 303 Score = 226 bits (576), Expect = 1e-57, Method: Composition-based stats. Identities = 72/305 (23%), Positives = 132/305 (43%), Gaps = 33/305 (10%) Query: 42 VPAKPVNCMGLTFKNPLGLAAGLDKDG-ECIDALGAMGFGSIEIGTVTPRPQPGNDKPRL 100 + VN L NP+ A+G G E D + G I + T + GN PR+ Sbjct: 1 MADLSVNIGDLKLCNPVMTASGTFGYGKEFEDFVDLEKIGGIIVKGTTLHHREGNPYPRM 60 Query: 101 FRLVDAEGLINRMGFNNLGVDNLVENVKKAHYD--GVLGINIGKNKDTPVEQGKDDYLIC 158 G++N +G N GVD VE++ D + +N+ + +DY+ Sbjct: 61 AE--TPMGMLNAVGLQNKGVDYFVEHIYPQIRDIHTNMIVNVSGS-------AVEDYVKT 111 Query: 159 MEKIYA--YAGYIAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPI 214 E I + I +NIS PN G+ +++ A++N + Sbjct: 112 AEIINDLDHIPAIELNISCPNVKQGGMAFGVSACGCSEVVKAVRNVYKKT---------L 162 Query: 215 AVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKN---CDQTGGLSGRPL 271 VK++P++++ + ++A + D V NT L ++ + TGG+SG + Sbjct: 163 IVKLSPNVTD--ITEIARAAEASGADSVSLINTLLGMAVDAEKRRPVLSTITGGMSGAAV 220 Query: 272 QLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKE 331 + + ++ +++ +N +P+IG+GGI A E + AGA+ +QI + F P + + Sbjct: 221 KPIALRMVWQVAKAVN--IPVIGLGGIMGWKDAVEFMLAGATAIQIGTAN-FIDPAITVK 277 Query: 332 IVTHI 336 + I Sbjct: 278 VSEGI 282 >UniRef50_O27281 Dihydroorotate dehydrogenase n=20 Tax=Euryarchaeota RepID=PYRD_METTH Length = 303 Score = 224 bits (571), Expect = 4e-57, Method: Composition-based stats. Identities = 63/300 (21%), Positives = 129/300 (43%), Gaps = 30/300 (10%) Query: 45 KPVNCMGLTFKNPLGLAAGLDKD-GECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRL 103 + + +NP LAAG+ ++ + G G++ + + RP PG P + Sbjct: 5 LETSICNIELRNPTILAAGVMGSMASSLNRIYRGGAGAVVTKSFSLRPNPGYRNPTTVEV 64 Query: 104 VDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIY 163 G+IN +G +N GV+ E +K + L ++ +++ + Sbjct: 65 --TGGVINAIGLSNPGVEAFREELKLVDEEVPLIASV-------YGASPEEFASAAASVE 115 Query: 164 AYAGYIAINISSPNT---PGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAP 220 YA I +N+S P+ G Q E +++A+K+ + VPI+ K+ P Sbjct: 116 EYADMIELNVSCPHAMAGCGASIGQDPELTFRVVSAVKDAVD---------VPISTKLTP 166 Query: 221 DLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQ----GMKNCDQTGGLSGRPLQLKST 276 ++++ ++++A S D + N+ + + GG+SG ++ + Sbjct: 167 NVTD--IVEIAGSAEEAGSDALTLINSLGPGMKIDIKTARPILSNAFGGMSGPAIKPVAV 224 Query: 277 EIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + + ++ +PI+GVGG+ A E + AGA VQ+ + ++ GP + +I + Sbjct: 225 RCVYDVYRSVD--IPIMGVGGVRDFQDAVEFLFAGARAVQVGTAIMYDGPEVFMKICRGL 282 >UniRef50_A9BJH4 Dihydroorotate dehydrogenase n=45 Tax=Bacteria RepID=PYRD_PETMO Length = 300 Score = 223 bits (568), Expect = 8e-57, Method: Composition-based stats. Identities = 81/300 (27%), Positives = 134/300 (44%), Gaps = 32/300 (10%) Query: 46 PVNCMGLTFKNPLGLAAGLDKDG-ECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLV 104 VN G+ FKNP+ A+G G E ++ G + +T R + GN R+ + Sbjct: 5 KVNIAGVEFKNPVIAASGTFGFGREFLEYFPISKLGGLATKGLTLREREGNKGVRIHETI 64 Query: 105 DAEGLINRMGFNNLGVDNLVENVKK--AHYDGVLGINIGKNKDTPVEQGKDDYLICMEKI 162 G++N +G N G+D +E D V+ N+ N D+Y+I +EK+ Sbjct: 65 --GGIMNSIGLQNPGIDAFIEEELPFLNSQDTVIIANVSGNT-------IDEYVISVEKL 115 Query: 163 YAY-AGYIAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIA 219 I +NIS PN G+ E +++T ++ P+ VK++ Sbjct: 116 NQTDIDMIELNISCPNVKEGGISFGTKAEIASNVVTQVRKVCQK---------PLIVKLS 166 Query: 220 PDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNC---DQTGGLSGRPLQLKST 276 P S E ++++A+S V D + NT ++ K + T GLSG ++ + Sbjct: 167 P--SAENIVEMAESCVEAGADALSLVNTFPALAIDISKKKAIFDNITAGLSGPCIKPIAL 224 Query: 277 EIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 ++ +S ++ +PIIG+GGI A E I AGA VQ+ + F P EI+ I Sbjct: 225 RMVYEVSKAVD--VPIIGIGGIMDYRDAIEYIMAGAWAVQVGTAN-FINPNACAEIIEGI 281 >UniRef50_C8WHP0 Dihydroorotate dehydrogenase family protein n=3 Tax=Bacteria RepID=C8WHP0_EGGLE Length = 356 Score = 222 bits (566), Expect = 1e-56, Method: Composition-based stats. Identities = 78/331 (23%), Positives = 137/331 (41%), Gaps = 32/331 (9%) Query: 17 RAHEFTFQQLRRITGTPF-EALVRQKVP---AKPVNCMGLTFKNPLGLAAGLDKDG-ECI 71 RA + Q GT E R+ VP VN GL KNP+ +A+G G E Sbjct: 26 RARSNSPQDCSIRCGTRLVEGCPRRPVPTSVDMRVNLGGLEMKNPVTVASGTFAAGREYG 85 Query: 72 DALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVEN--VKK 129 D + G G++ V+ GN PR+ G++N +G N GV +L E Sbjct: 86 DFVDVAGLGAVTTKGVSLNGWAGNASPRIAE--TPSGMLNSIGLQNPGVAHLKECDLPWL 143 Query: 130 AHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYA-GYIAINISSPNTPGLRTLQYGE 188 A + +N+ D+Y+ +E + +NIS PN + G Sbjct: 144 AERGATVIVNVS-------GHSFDEYVQVIEALEDVPVDAYEVNISCPNV-DAGGMTIGT 195 Query: 189 ALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTT 248 D + + + + P+ VK+ P++++ + ++A + V D + NT Sbjct: 196 CTDSVEAVVSRCRAATKR------PLIVKLTPNVTD--VTEIARAAVSAGADALSLINTL 247 Query: 249 LDRSLVQGMKN---CDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAR 305 L ++ + GGLSG ++ + ++ + ++ +P++G+GGI A Sbjct: 248 LGMAIDAERRRPQLARGVGGLSGPAVKPVALRMVWEVHQAVD--VPLLGMGGISCATDAV 305 Query: 306 EKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 E + AGA+ V + + F P EI+ + Sbjct: 306 EFMLAGATAVAVGTAN-FVNPHATVEIIDGM 335 >UniRef50_C8W700 Dihydroorotate dehydrogenase family protein n=2 Tax=Atopobium RepID=C8W700_ATOPD Length = 308 Score = 220 bits (562), Expect = 4e-56, Method: Composition-based stats. Identities = 73/298 (24%), Positives = 126/298 (42%), Gaps = 25/298 (8%) Query: 46 PVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGF-GSIEIGTVTPRPQPGNDKPRLFRLV 104 VN G+ KNP+ AAG G + + G+I + V P GN PR+ L Sbjct: 8 AVNLGGIQMKNPINTAAGTFGYGWQFEGFYDVSLLGAITMKGVARVPWEGNPAPRMCEL- 66 Query: 105 DAEGLINRMGFNNLGVDNLVENVKKAHYD-GVLGINIGKNKDTPVEQGKDDYLICMEKIY 163 G++N +G N GVD+ + + D G + Q D + +E++ Sbjct: 67 -NGGMMNSVGLANPGVDDFIAHTDDYMKDLEDRGTRVIMQMAAHSVQEMIDVVERLEELN 125 Query: 164 AYAGYIAINISSPNT-PGLRTLQY-GEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPD 221 + I +N+S PN G R L E +++ A++ +PI VK+AP Sbjct: 126 PHISAIELNVSCPNLEKGGRPLGGTPEQATEIMKAVRPLTK---------LPILVKMAP- 175 Query: 222 LSEEELIQVADSLVRHNIDGVIATNTTLDRSL---VQGMKNCDQTGGLSGRPLQLKSTEI 278 + ++ + DG+ N+ S+ + + TGGLSG + + Sbjct: 176 ---VNVAEIGKAFEAEGADGLTLINSIPGMSINVHTRKSRLSKPTGGLSGPLCHNAAVRM 232 Query: 279 IRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + + ++ +PI GVGG+++ A E I AGA+ V + S ++ P I+ + Sbjct: 233 VWECAQAVS--IPICGVGGVETGEDAAEFILAGATAVSVGSANLYD-PMCAPRILNEL 287 >UniRef50_Q1G992 Dihydroorotate dehydrogenase n=3 Tax=Lactobacillus delbrueckii RepID=Q1G992_LACDA Length = 309 Score = 220 bits (561), Expect = 6e-56, Method: Composition-based stats. Identities = 78/302 (25%), Positives = 138/302 (45%), Gaps = 33/302 (10%) Query: 45 KPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLV 104 V GL KNP+ A+G G+ + G+I + T T + GN +P++ L Sbjct: 7 LAVELPGLKLKNPVMPASGTFAFGDLPENFNWDEMGAIVLKTATRHARTGNPQPQIDLLA 66 Query: 105 DAEGLINRMGFNNLGVDNLVEN----VKKAHYDGVLGINIGKNKDTPVEQGKDDYLICME 160 D G++N +G N G + + +++ H D + ++G + +DY+ E Sbjct: 67 D--GVMNAVGLTNPGAEVVASEKIPALREKHPDLPILASVG-------GESVEDYVEVAE 117 Query: 161 KIYAY-AGYIAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVK 217 + A + +N+S PN G+ E L+ + +K K + +P+ VK Sbjct: 118 ILAAAKPDALELNLSCPNVSEGGMTFGIVPEMLEKITRLVKEKVD---------LPVYVK 168 Query: 218 IAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKN---CDQTGGLSGRPLQLK 274 + P+++ ++++A + DG+ NT L L + + GGL G+ ++ Sbjct: 169 LTPNVT--SIVEIAQAAEGGGADGLTLINTLLVLHLDLKTRRPVLGNDFGGLYGQAVKPV 226 Query: 275 STEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVT 334 + ++ ++ + LPIIGVGGI+S A E I AGAS VQI S F IK ++ Sbjct: 227 AVRMVAQVKQATS--LPIIGVGGINSPEDAAEFILAGASAVQIGS-MSFYDKLAIKHVID 283 Query: 335 HI 336 + Sbjct: 284 GL 285 >UniRef50_C0QYH6 Dihydroorotate dehydrogenase n=2 Tax=Brachyspira RepID=PYRD_BRAHW Length = 303 Score = 219 bits (559), Expect = 9e-56, Method: Composition-based stats. Identities = 73/304 (24%), Positives = 134/304 (44%), Gaps = 31/304 (10%) Query: 42 VPAKPVNCMGLTFKNPLGLAAGLDKDGE-CIDALGAMGFGSIEIGTVTPRPQPGNDKPRL 100 + +N +G KN + ++G GE + G++ + +T + GN R+ Sbjct: 1 MSRLNINFLGKELKNNVITSSGCFGFGEEYSNYFDVNELGAVNLKGITLNKKDGNKGTRI 60 Query: 101 FRLVDAEGLINRMGFNNLGVDNLVENV-KKAHYDGVLGINIGKNKDTPVEQGKDDYLICM 159 G+IN +G N G++ +N+ K Y + +NI D+Y+ Sbjct: 61 AE--TPSGMINCIGLENPGIEYFKDNIIKNIKYSTPIILNI-------NGATIDEYVKVA 111 Query: 160 EKIYAY--AGYIAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIA 215 E ++ +NIS PN G+ E+ + A+K + P+ Sbjct: 112 EIANEIERVDFVELNISCPNVKNGGMAFGASCESAESTTKAVKKVLSK--------KPLI 163 Query: 216 VKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKN---CDQTGGLSGRPLQ 272 VK++P++++ + +A ++ D V NT L + + + GGLSG ++ Sbjct: 164 VKLSPNVTD--IASIAKAVEDAGADSVSLVNTFLSMKIDTKTRKPLLGNIFGGLSGACIR 221 Query: 273 LKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 + ++ ++ + ++PI+G+GGI + A E I AGASLV I +G IF P L E+ Sbjct: 222 PIAVRMVYQVYKAV--KIPIVGMGGITNYNDALEFILAGASLVSIGAG-IFSNPILPIEV 278 Query: 333 VTHI 336 + I Sbjct: 279 INGI 282 >UniRef50_C4F860 Putative uncharacterized protein n=2 Tax=Collinsella RepID=C4F860_9ACTN Length = 307 Score = 218 bits (555), Expect = 3e-55, Method: Composition-based stats. Identities = 66/300 (22%), Positives = 118/300 (39%), Gaps = 29/300 (9%) Query: 46 PVNCMGLTFKNPLGLAAGLDKDGECI-DALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLV 104 V+ G+ KNP+ A+G G + + G+I PGN PR+ + Sbjct: 7 AVDFGGVKMKNPINTASGTFGYGWQFSELMDVSQLGAITTKGCAAEAWPGNPAPRMAEVP 66 Query: 105 DAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICME---K 161 G++N +G N GV E + + L + ++Y+ +E + Sbjct: 67 --GGMMNSVGLQNPGVAAFAE--QSGPWLADLTAKGTQVICQVAGHSTEEYVRALEMFVE 122 Query: 162 IYAYAGYIAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIA 219 + +A IN+S PN G E +++ A + + P+ VK+A Sbjct: 123 LCPWAAGYEINVSCPNIAAGGAACGSTPEGASEVMRACRKVTDK---------PLFVKMA 173 Query: 220 PDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLV---QGMKNCDQTGGLSGRPLQLKST 276 P + ++A +L DG+ N+ S+ + + TGGLSG + Sbjct: 174 P----VRIPEIARALEAEGADGLTVINSIPGMSIDVRTRRSRLSKPTGGLSGPLCHPIAV 229 Query: 277 EIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 ++ + ++ +PI GVGG+ + A E I AGA V + + P I+ + Sbjct: 230 RMVWEAANAVD--IPICGVGGVMTGEDAAEFILAGACCVSVGMANFVE-PDASVRILHEL 286 >UniRef50_B2WMQ8 Dihydroorotate dehydrogenase, mitochondrial n=3 Tax=Leotiomyceta RepID=B2WMQ8_PYRTR Length = 455 Score = 216 bits (551), Expect = 8e-55, Method: Composition-based stats. Identities = 83/310 (26%), Positives = 132/310 (42%), Gaps = 47/310 (15%) Query: 23 FQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSI 82 + L P E + V G T NP+G +AG+DK E L +G G + Sbjct: 2 LKVLHSFGMNPRERGIADTQGDLAVEVFGHTLNNPIGTSAGIDKGAEIPTPLFELGAGVV 61 Query: 83 EIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKKAHYD--------- 133 E+G VT PQ GN KPR+FRL LINR GFN+ G + + +++ + Sbjct: 62 EVGAVTLLPQEGNPKPRVFRLPSQNALINRYGFNSEGAELVASRLRQRVREFAYRIGLGL 121 Query: 134 -----------------------GVLGINIGKNKDT---PVEQGKDDYLICMEKIYAYAG 167 ++ + + KNK T ++ DY + + YA Sbjct: 122 DEDAERRVLDGEAGVPPGSLLKGRLMAVQVAKNKTTSENDIDAVVRDYATAVGYVGKYAD 181 Query: 168 YIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLS-EEE 226 + +N+SSPNTPGLRTLQ E L LL+ + + + + VK++PD E + Sbjct: 182 ILVVNVSSPNTPGLRTLQNVEPLTRLLSGVVSAVKKIDRKTKPA--VMVKVSPDEDSESQ 239 Query: 227 LIQVADSLVRHNIDGVIATNTTLDRSLVQGM---------KNCDQTGGLSGRPLQLKSTE 277 + + +++ +DGVI NTT R K + GG SG + ++ Sbjct: 240 IAGICEAVWDSGVDGVIVGNTTKKRPDPLPKGYLLPESEAKLLLEQGGYSGPQMFERTLA 299 Query: 278 IIRRLSLELN 287 ++ + L+ Sbjct: 300 LVSKYRKALD 309 Score = 61.0 bits (147), Expect = 5e-08, Method: Composition-based stats. Identities = 18/48 (37%), Positives = 25/48 (52%) Query: 289 RLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 R I GGI + ARE + AGAS+ Q+Y+ I+ G I I + Sbjct: 395 RKVIFATGGITNGRQAREILDAGASVAQVYTAMIYGGAGTISRIKQEM 442 >UniRef50_C9KKE5 Dihydroorotate oxidase n=6 Tax=Bacteria RepID=C9KKE5_9FIRM Length = 316 Score = 215 bits (549), Expect = 1e-54, Method: Composition-based stats. Identities = 70/302 (23%), Positives = 131/302 (43%), Gaps = 32/302 (10%) Query: 44 AKPVNCMGLTFKNPLGLAAGLDKDGE-CIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFR 102 N +G+ + P+ A+G GE D + G + + T P+ GND R+ Sbjct: 5 RLHTNLLGIAMQTPVLTASGTFGFGEEFADFVDLSRLGGVMVKGTTLLPRRGNDGVRITE 64 Query: 103 LVDAEGLINRMGFNNLGVDNLVENV--KKAHYDGVLGINIGKNKDTPVEQGKDDYLICME 160 +G++N +G N GV++ ++ + Y + +NI + +DY Sbjct: 65 --TPKGMLNCIGLENPGVEHFLKETLPRIQQYGMNVIVNISGST-------AEDYGKLAG 115 Query: 161 KIY-AYAGYIAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVK 217 + I +N+S PN G+ EA ++ A K H P+ +K Sbjct: 116 LLDVPGVAAIELNVSCPNVKEGGIVFGTDPEAASAVVRAAKA---------HTKKPVILK 166 Query: 218 IAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGM---KNCDQTGGLSGRPLQLK 274 ++P++++ ++ +A ++ D V NT L + + TGGLSG ++ Sbjct: 167 LSPNVTD--IVAMAKAVEAAGADAVSLINTLLGMEIDIHRFRPVLGNITGGLSGPCVKPV 224 Query: 275 STEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVT 334 + ++ +++ ++ +PIIG+GGI S A E AGAS V + + F P + +I Sbjct: 225 AVRMVWQVAQAVH--IPIIGMGGIASAEDAVEFFLAGASAVAVGTAN-FTDPEITMKICD 281 Query: 335 HI 336 + Sbjct: 282 GL 283 >UniRef50_A6G037 Dihydroorotate dehydrogenase 1 n=1 Tax=Plesiocystis pacifica SIR-1 RepID=A6G037_9DELT Length = 334 Score = 215 bits (548), Expect = 2e-54, Method: Composition-based stats. Identities = 71/312 (22%), Positives = 126/312 (40%), Gaps = 24/312 (7%) Query: 32 TPFEALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDGE-CIDALGAMGFGSIEIGTVTPR 90 TP V + + L ++P+ A+G G+ + + G + ++P Sbjct: 5 TPTATPVPLESVELACDFGPLKLRSPILTASGCFAYGQQFAEFMDLRQIGGLSTKGISPL 64 Query: 91 PQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNK-DTPVE 149 P+ GN PR++ A G+IN +G N+G + + +K + L +++ N T E Sbjct: 65 PRHGNPLPRIYE--TASGMINSIGLENVGCEAFL--TEKLPFLADLDVSVWVNFFGTDFE 120 Query: 150 QGKDDYLICMEKIYAYAGYIAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAM 207 D E + +NIS PN G+ E L A Sbjct: 121 TYVDCAKTLSEGGEGRIDVLEMNISCPNIKKGGIEFGTVPEVAHRLTKACVEA------- 173 Query: 208 HHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLV---QGMKNCDQTG 264 VPI VK+ P++S+ ++ +A ++ GV NT ++ + + G Sbjct: 174 --SEVPIVVKLTPNVSD--IVAMAQAVKEAGAIGVSLINTITAMAIDVRSRRSRIATTYG 229 Query: 265 GLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFK 324 GLSG ++ + ++ +++ L G PI G+GGI + E AGA VQ+ + F Sbjct: 230 GLSGPAIKPVALRMVHQVAKALPG-FPICGMGGILTGEDVLEYFIAGAHCVQLGT-INFS 287 Query: 325 GPPLIKEIVTHI 336 P + + Sbjct: 288 EPGAALRVTREL 299 >UniRef50_Q3AC05 Dihydroorotate dehydrogenase n=1 Tax=Carboxydothermus hydrogenoformans Z-2901 RepID=PYRD_CARHZ Length = 307 Score = 215 bits (548), Expect = 2e-54, Method: Composition-based stats. Identities = 71/300 (23%), Positives = 132/300 (44%), Gaps = 29/300 (9%) Query: 45 KPVNCMGLTFKNPLGLAAGLDKDG-ECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRL 103 V LT KNP+ A+G G E D G++ + T+T P+ GN PR++ + Sbjct: 3 LKVKIGELTLKNPVMPASGTFGFGLEFKDIFDLKNLGALVVKTITKNPRLGNRPPRVYEV 62 Query: 104 VDAEGLINRMGFNNLGVDNLVENVKKA--HYDGVLGINIGKNKDTPVEQGKDDYLICMEK 161 + G+IN +G N G D E + + +L +NI + YL + Sbjct: 63 --SCGMINSIGLANPGWDYFCEKILPQIKDLNDILILNIAGESVEEFQ-----YLAREAQ 115 Query: 162 IYAYAGYIAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIA 219 + + +N+S PN G+ EAL ++++++ + + VK+ Sbjct: 116 RFDEIKALELNVSCPNVSKGGIAFGTDLEALKQIVSSVRKIYSKT---------LIVKLT 166 Query: 220 PDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKN---CDQTGGLSGRPLQLKST 276 P++++ + A + D + NT + K ++ GG+SG ++ + Sbjct: 167 PNVTD--ITVYAKAAENAGADALTLINTFTGMVIDVKSKKPILGNKHGGVSGPAIRPMAV 224 Query: 277 EIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 +++ ++ +PIIGVGGIDS AA E AGA+ +Q+ S + P + ++ + Sbjct: 225 KMVYDCFKAVS--IPIIGVGGIDSKEAALEFFLAGATAIQVGSQNFVE-PGFMPRLIREL 281 >UniRef50_Q2NEG1 PyrD n=1 Tax=Methanosphaera stadtmanae DSM 3091 RepID=Q2NEG1_METST Length = 306 Score = 215 bits (547), Expect = 2e-54, Method: Composition-based stats. Identities = 64/303 (21%), Positives = 130/303 (42%), Gaps = 32/303 (10%) Query: 45 KPVNCMGLTFKNPLGLAAG-LDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRL 103 +G+ NPL LAAG L + + G G I + + G D P + ++ Sbjct: 2 LEQEILGMKLSNPLFLAAGILGTTASSMKMVARAGAGGIVTKSFSIEANDGYDNPTIVKI 61 Query: 104 VDAEGLINRMGFNNLGVDNLVENVK---KAHYDGVLGINIGKNKDTPVEQGKDDYLICME 160 G+IN +G + GV+ E +K + + +I ++ + Sbjct: 62 --EGGVINSVGLASPGVEAKKEELKDLNEIRDKTPVIASI-------YGDSEEVFSDVAN 112 Query: 161 KIYAYAGYIAINISSPNTP---GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVK 217 + Y +N+S P+ G + E D+++++K+ + K VPI VK Sbjct: 113 QTKDYVDAFELNVSCPHAKCGFGSNIGENPELTHDIVSSVKD--------NIKDVPIIVK 164 Query: 218 IAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQ----GMKNCDQTGGLSGRPLQL 273 + P++++ + ++A + D + N+ + + GG++G ++ Sbjct: 165 LTPNVTD--ITEIAKAAEDAGADALTLINSVGPGLRIDYKTARPILNNVFGGIAGPMIKP 222 Query: 274 KSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIV 333 + + + + ++ +P+ GVGGI + A E + AGASL+QI + +++GP + K I Sbjct: 223 IALKCVYKTYETVD--IPLFGVGGIRTYKDALEFLYAGASLLQIGTSIMYEGPEIFKNIT 280 Query: 334 THI 336 + Sbjct: 281 HDL 283 >UniRef50_A4ECL7 Putative uncharacterized protein n=1 Tax=Collinsella aerofaciens ATCC 25986 RepID=A4ECL7_9ACTN Length = 302 Score = 213 bits (544), Expect = 5e-54, Method: Composition-based stats. Identities = 67/304 (22%), Positives = 117/304 (38%), Gaps = 37/304 (12%) Query: 46 PVNCMGLTFKNPLGLAAGLDKDGECID-ALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLV 104 V+ G+ +NP+ AAG G G+I P PGN PR+ + Sbjct: 2 AVDFGGVKMQNPINTAAGTFGYGWQFQNFFDVSQLGAITTKGCAAEPWPGNPAPRMAEIP 61 Query: 105 DAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPV----EQGKDDYLICME 160 G+IN +G N GV G + K+ + D+++ +E Sbjct: 62 --GGMINSVGLQNPGVAAFARE------SGPWLEQLSKDGCQVICQVAGHSVDEFVRALE 113 Query: 161 ---KIYAYAGYIAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIA 215 ++ +A IN+S PN G E ++ A + + P+ Sbjct: 114 MYVELCPWAAGYEINVSCPNIAAGGAAMGSTPEGASSVMAACRKVTDK---------PLF 164 Query: 216 VKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLV---QGMKNCDQTGGLSGRPLQ 272 VK+AP + ++A +L DG+ N+ ++ + + GGLSG Sbjct: 165 VKMAP----VNVAEIAKALEAAGADGLSVINSIQGMAIDVHTRKSRVAKPKGGLSGPLCH 220 Query: 273 LKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 + ++ ++ ++ +PI GVGG+ + A E I AGA+ V + F P +I Sbjct: 221 HIAVRMVWEVAQAVD--IPINGVGGVMTGEDAAEFILAGATCVSVGMAN-FVDPCASLKI 277 Query: 333 VTHI 336 + Sbjct: 278 AHEL 281 >UniRef50_B5YJH1 Dihydroorotate dehydrogenase n=24 Tax=Bacteria RepID=PYRD_THEYD Length = 303 Score = 213 bits (543), Expect = 7e-54, Method: Composition-based stats. Identities = 78/302 (25%), Positives = 133/302 (44%), Gaps = 27/302 (8%) Query: 42 VPAKPVNCMGLTFKNPLGLAAGLDKDG-ECIDALGAMGFGSIEIGTVTPRPQPGNDKPRL 100 +P V L+FKNP+ A+G G E + G I + ++ +P+ GN PR+ Sbjct: 1 MPVLEVKIGNLSFKNPVLTASGTFGYGLEYSQFVDLNILGGIVVKGLSLKPKQGNPPPRI 60 Query: 101 FRLVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICME 160 + G+IN +G N+G++ + K + NI N + D+Y+ + Sbjct: 61 YE--TPCGMINSIGLQNIGLEAFKKE--KLPFLKKFNTNIIVNF---FGENLDEYIEVAK 113 Query: 161 KIYAYAGY--IAINISSPN-TPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVK 217 + G + +N+S PN T R + G + L AIK + ++ P+ VK Sbjct: 114 LLDETEGVHALEMNVSCPNKTSEWRKM--GLEPELLREAIKRVRLHIKK------PLIVK 165 Query: 218 IAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQ---TGGLSGRPLQLK 274 +AP ++E L +A D V NT + + TGGLSG ++ Sbjct: 166 LAPQVTEIAL--MARICEEEGADAVSLINTIPAMVIDIKTRKSMIGTLTGGLSGPAIRPV 223 Query: 275 STEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVT 334 + + ++ + ++P+IGVGGI S A + + AGA +Q+ + F P EI+ Sbjct: 224 ALRAVWEVAQAV--KIPVIGVGGIVSAEDALQFLIAGAKAIQVGTAN-FINPIATVEIIE 280 Query: 335 HI 336 I Sbjct: 281 GI 282 >UniRef50_C9RJ75 Dihydroorotate oxidase n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RJ75_FIBSS Length = 391 Score = 213 bits (542), Expect = 9e-54, Method: Composition-based stats. Identities = 88/344 (25%), Positives = 141/344 (40%), Gaps = 30/344 (8%) Query: 5 FVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKP--VNCMG----LTFKNPL 58 +R+ +F +PE H+ R PF V L F P+ Sbjct: 21 LIRR-IFHNNPEFRHDSLKHVARFAPIIPFMGGRPDLSKTLNRVVTFADGSNPLHFGCPI 79 Query: 59 GLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGN-DKPRLFRLVDAEGLINRMGFNN 117 LAAG +K + I MGFG I +GT T + GN +PR+ + + + N MG NN Sbjct: 80 MLAAGANKTAKRICDFANMGFGGISVGTATRHVREGNTHRPRIGFIENDRAIHNSMGLNN 139 Query: 118 LGVDNLVENV-----KKAHYDGVLGINIGKN-KDTPVEQGKDDYLICMEKIYAYAGYIAI 171 GVD + V +GI++ + T + D + Y A Y+ I Sbjct: 140 DGVDAVTRRVDTQITAAHRVQMCVGISVAETPGLTDENEKLQDIVESFSIAYRVADYVEI 199 Query: 172 NISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVA 231 N+S PNT R ++ + TAI + +N I K++PD+ E + Sbjct: 200 NLSCPNTGENRLDLDMTLVNKIFTAITDYRNKQPVRKA----IYAKLSPDMPENHTATIM 255 Query: 232 DSLVRHNIDGVIATNTTLDRSL-----------VQGMKNCDQTGGLSGRPLQLKSTEIIR 280 D LV+ ++GV+ NT + + + ++ + GG+SGRPL + ++ Sbjct: 256 DMLVKVGVNGVVMGNTYPTKKVTDLPVHVKYDDLTPLRADNDRGGMSGRPLYENTVRNVK 315 Query: 281 RLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFK 324 + ++ +I GGID + I G VQ YS F+ Sbjct: 316 FIREH-YPQMSVIACGGIDHGYKIYDLIKLGVDAVQCYSVVAFR 358 >UniRef50_Q01YA2 Dihydroorotate dehydrogenase n=5 Tax=Bacteria RepID=PYRD_SOLUE Length = 304 Score = 212 bits (540), Expect = 2e-53, Method: Composition-based stats. Identities = 70/303 (23%), Positives = 125/303 (41%), Gaps = 29/303 (9%) Query: 42 VPAKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAM-GFGSIEIGTVTPRPQPGNDKPRL 100 P G+ KNP+ A+G G + L + G + ++ P GN PR+ Sbjct: 2 TPQLATTICGIALKNPVLAASGTFAYGVEFEKLVDLNALGGFVVKGLSREPIEGNPPPRV 61 Query: 101 FRLVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICME 160 F G+IN +G N+GV V + G+ + +DY+ + Sbjct: 62 FE--SEAGMINSVGLQNIGVRAFVAE----KLPALAGLRTAVFAN-VFGYCTEDYVEVVR 114 Query: 161 KIYAYAGY--IAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAV 216 + +AG +N+S PNT G+ L +++TA K P+ V Sbjct: 115 VLNDHAGLAGYELNVSCPNTAHGGIYFSNDPVLLAEVVTAAKRVATR---------PLIV 165 Query: 217 KIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLV---QGMKNCDQTGGLSGRPLQL 273 K++P++S + +A D + NT + ++ + + GGLSG ++ Sbjct: 166 KLSPNVS--AIEPLARVAEESGADALSLVNTVISLAIDARTRRPRIGAGFGGLSGPAIKP 223 Query: 274 KSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIV 333 + + + + + R+P+IG+GGI + A E + AGAS V++ + F P I Sbjct: 224 IALRFVYQAARAV--RIPVIGLGGIATGEDAAEFLIAGASAVEVGTA-TFWDPRAPLRIA 280 Query: 334 THI 336 + Sbjct: 281 EEL 283 >UniRef50_C6SRR7 Putative dihydroorotate dehydrogenase dihydroorotate oxidase n=1 Tax=Streptococcus mutans NN2025 RepID=C6SRR7_STRMN Length = 330 Score = 212 bits (539), Expect = 2e-53, Method: Composition-based stats. Identities = 74/304 (24%), Positives = 125/304 (41%), Gaps = 35/304 (11%) Query: 47 VNCMGLTFKNPLGLAAGLD-KDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVD 105 F N L AAG+ E + A+ GS T T + GN +PR Sbjct: 25 TTIGSFDFDNCLMNAAGVYCMTREELAAIDHSEAGSFVTKTGTLEERAGNPQPRYA--DT 82 Query: 106 AEGLINRMGFNNLGVDNLVENVK--------KAHYDGVLGINIGKNKDTPVEQGKDDYLI 157 G IN MG NLG++ ++ V K H+ ++G++ P E ++ Sbjct: 83 KLGSINSMGLPNLGINYYLDYVTELQKQPDSKNHFLSLVGMS-------PEETHT---IL 132 Query: 158 CMEKIYAYAGYIAINISSPNTPGLRTLQYG-EALDDLLTAIKNKQNDLQAMHHKYVPIAV 216 M + Y G + +N+S PN PG + Y E D +L+ + + P+ + Sbjct: 133 KMVEASKYQGLVELNLSCPNVPGKPQIAYDFETTDQILSEV---------FTYFTKPLGI 183 Query: 217 KIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQG----MKNCDQTGGLSGRPLQ 272 K+ P Q A ++ + V N+ + +++ +K + GG+ G ++ Sbjct: 184 KLPPYFDIVHFDQAAAIFNKYPLTFVNCINSIGNGLVIEDETVVIKPKNGFGGIGGDYVK 243 Query: 273 LKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 + + LN + IIG GG+ + A E I GAS+VQI + +GP + K I Sbjct: 244 PTALANVHAFYKRLNPSIQIIGTGGVKTGRDAFEHILCGASMVQIGTALHQEGPQIFKRI 303 Query: 333 VTHI 336 + Sbjct: 304 TKEL 307 >UniRef50_B5YFH3 Dihydroorotate dehydrogenase n=2 Tax=Dictyoglomus RepID=B5YFH3_DICT6 Length = 306 Score = 212 bits (539), Expect = 2e-53, Method: Composition-based stats. Identities = 71/297 (23%), Positives = 126/297 (42%), Gaps = 26/297 (8%) Query: 45 KPVNCMGLTFKNPLGLAAGLDKDGECIDALGAM-GFGSIEIGTVTPRPQPGNDKPRLFRL 103 V L FKNP+ LA+G +G I+ + G G ++T P+ GN PR++ Sbjct: 4 LEVRIGSLIFKNPILLASGTCGNGREINKFYDINGLGGFVTKSITLNPREGNPPPRIWE- 62 Query: 104 VDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIY 163 G++N +G N+G+ +E + + L N+ + E+ ++ Y I Sbjct: 63 -SYAGILNSIGLENVGLQKFLEE--EMPFLERLSTNVIVS--IAGEKKEEYYEIARNLRG 117 Query: 164 AYAGYIAINISSPNTPGLRTL--QYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPD 221 + +N+S PN G L E + ++ + + P+ VK+ P Sbjct: 118 CKISGVELNLSCPNVEGGGMLFGIDKEMVKEITKKVVKEIGK---------PVWVKLTPQ 168 Query: 222 LSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKN---CDQTGGLSGRPLQLKSTEI 278 ++++++ ++ + V+ NT L ++ + G SG ++ Sbjct: 169 --AKDIVEIVKAVKDAGGEAVVLFNTFLGLAIDWKKRKPVFKRIFAGYSGPAVKPLVLRY 226 Query: 279 IRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTH 335 + + E LPI+G GGI S E I AGASLVQI S F+ P + + +V Sbjct: 227 VWEVYEE--NLLPIVGCGGIVSFSDVLEYIFAGASLVQIGSAN-FRDPWIGERLVKE 280 >UniRef50_Q979G6 Dihydroorotate dehydrogenase n=4 Tax=Thermoplasmatales RepID=PYRD_THEVO Length = 301 Score = 212 bits (539), Expect = 2e-53, Method: Composition-based stats. Identities = 69/298 (23%), Positives = 126/298 (42%), Gaps = 30/298 (10%) Query: 42 VPAKPVNCMGLTFKNPLGLAAG-LDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRL 100 + G+ NP +A+G LD++G + L G ++ ++ + G P + Sbjct: 1 MSDISTTLAGIKLVNPFMVASGILDENGYTMKELLERGAAAVVTKSIGISERDGYPTPVI 60 Query: 101 FRLVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICME 160 + LIN +G +N G++N E + A I + +++ Sbjct: 61 VEY--GDSLINAVGLSNPGIENFGEEINIAKEAKRPII------GSVFAYNAEEFTKLSV 112 Query: 161 KIYAY-AGYIAINISSPNTPG--LRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVK 217 K+ Y I +N+S P+ G L + ++D++ IK+K VP+ K Sbjct: 113 KMEEYGVDAIELNLSCPHVKGFGLEVGSDPDLVEDIVNEIKSKVK---------VPVFAK 163 Query: 218 IAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLV---QGMKNCDQTGGLSGRPLQLK 274 ++P++S +I++A + + D + NT ++ + + GGLSG ++ Sbjct: 164 LSPNVS--NIIEIAKAAEKA--DAYVLINTVKAMAIDIYSRSPVLSNLYGGLSGPAIKPV 219 Query: 275 STEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 + + E IIGVGGI + A E I AGAS VQI + G + +E+ Sbjct: 220 GIRYVYEVKKETGKE--IIGVGGISNYKDAIEYIMAGASAVQIGTALYKYGKGIFREM 275 >UniRef50_Q0W8E1 Dihydroorotate dehydrogenase n=18 Tax=Euryarchaeota RepID=PYRD_UNCMA Length = 301 Score = 208 bits (529), Expect = 3e-52, Method: Composition-based stats. Identities = 75/296 (25%), Positives = 128/296 (43%), Gaps = 29/296 (9%) Query: 47 VNCMGLTFKNPLGLAAG-LDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVD 105 N GLT KNP LAAG L G + + +MG G++ ++ P+PG+ P + RL Sbjct: 5 CNAGGLTLKNPTILAAGVLGTTGASLKRIASMGAGAVVTKSIGTEPKPGHHNPSMIRL-- 62 Query: 106 AEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAY 165 EG IN MG N + ++ A GV I + + + Sbjct: 63 EEGYINAMGLPNPSFGEFRQELEIARESGVPVI-------ASIFGATPEEFTAVANGLPG 115 Query: 166 AGYIAINISSPNTPG--LRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLS 223 A +N+S P+ G ++ E + + A+K VP+ VK+ P+++ Sbjct: 116 ADAYELNVSCPHAKGYGMQCGTDPELVRSITKAVKAAVK---------VPVWVKLTPNVT 166 Query: 224 EEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMK---NCDQTGGLSGRPLQLKSTEIIR 280 + I +A D V+A NT ++ +++GGLSG ++ + + + Sbjct: 167 DIRPIGLA--AQEGGADAVVAINTLKAMAIDINTGWPILGNRSGGLSGPAVKPVAIKCVY 224 Query: 281 RLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 L L+ +P+IGVGG+ + A E + AGA V+I S +++ + I Sbjct: 225 DLYEVLD--IPVIGVGGVSNWADAIEFMMAGACAVEIGSA-VYEDIGTFASVSMGI 277 >UniRef50_A9A3M4 Dihydroorotate dehydrogenase family protein n=2 Tax=Thaumarchaeota RepID=A9A3M4_NITMS Length = 303 Score = 207 bits (527), Expect = 5e-52, Method: Composition-based stats. Identities = 72/300 (24%), Positives = 128/300 (42%), Gaps = 27/300 (9%) Query: 43 PAKPVNCMGLTFKNPLGLAAGLDK-DGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLF 101 P + + P+ LA+G+ + L G G++ +++ P G P +F Sbjct: 3 PNLATSIGPIQLDRPVMLASGILGISLDVFSRLYRSGAGAVVTKSLSTEPWEGYPNPTIF 62 Query: 102 RLVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEK 161 + G IN +G +N G +N + ++ + D + +++ + E+ + C K Sbjct: 63 SV-KGGGWINAVGLSNPGAENFAKMIEP-NQDVPIIVSLVGSIPEDFEKMIKQFENC--K 118 Query: 162 IYAYAGYIAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIA 219 + AY +N+S P+ GL E + ++T +KN N VP+ K+ Sbjct: 119 VTAY----ELNLSCPHVAKVGLEVGDDPELVKKIVTTVKNSTN---------VPVIAKVG 165 Query: 220 PDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLV---QGMKNCDQTGGLSGRPLQLKST 276 L + + + ID + A NT ++ Q ++ GGLSG P++ + Sbjct: 166 --LGTTHYLNTVGTAIESGIDAITAINTVRSMAIDVETQRPILSNKFGGLSGTPIKPIAL 223 Query: 277 EIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + +S + + +PIIG GGI + A E AGAS VQ+ S + EI T I Sbjct: 224 RCVYEISSKYD--IPIIGCGGISTWEDAVEFFLAGASSVQLGSAIGDNWIDVFNEINTGI 281 >UniRef50_B1MZ73 Dihydroorotate dehydrogenase B, catalytic subunit n=1 Tax=Leuconostoc citreum KM20 RepID=B1MZ73_LEUCK Length = 306 Score = 207 bits (527), Expect = 5e-52, Method: Composition-based stats. Identities = 64/300 (21%), Positives = 133/300 (44%), Gaps = 26/300 (8%) Query: 44 AKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRL 103 V GL KNP+ ++G G G++ TVT + GN +P + + Sbjct: 5 RLAVKLPGLDLKNPIMNSSGAVFFGLEDKGYAIEETGALVTKTVTMSARAGNPQPWI--I 62 Query: 104 VDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIY 163 G++N +G N G++ +V ++ A ++ + + + + +Y+ E++ Sbjct: 63 NTPSGILNSVGLANPGIEAVVADILPAIHEKYKTLPV---LASVAGETVGEYVALTERLT 119 Query: 164 A--YAGYIAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIA 219 A I N+S PN G+ E+ +++ A++ +PI K++ Sbjct: 120 ATKQVTAIEANLSCPNVDRGGMAFGVTAESAAEVIHAMRAATT---------LPIYAKMS 170 Query: 220 PDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLV---QGMKNCDQTGGLSGRPLQLKST 276 P++++ + + ++ DG++ NT + SL + + TGG+SG + + Sbjct: 171 PNVTD--IKPIVKAVETAGADGIVLINTVVGMSLDLNTRQARLARGTGGMSGTSVHPIAV 228 Query: 277 EIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + + ++ +P+IGVGG+ +V E + AGAS VQI + ++ +I+ + Sbjct: 229 RFVYETAQTVS--IPVIGVGGVSTVDDVLELMMAGASAVQIGTALA-GNHQVMADIIREL 285 >UniRef50_C6A1L2 Dihydroorotate dehydrogenase family protein n=1 Tax=Thermococcus sibiricus MM 739 RepID=C6A1L2_THESM Length = 309 Score = 207 bits (526), Expect = 6e-52, Method: Composition-based stats. Identities = 80/299 (26%), Positives = 134/299 (44%), Gaps = 26/299 (8%) Query: 44 AKPVNCMGLTFKNPLGLAAGLDKDG-ECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFR 102 ++ G+ F+NP+ LA+G G E + L G+I + TVT +P+ GN PRL Sbjct: 4 DLSIDVFGIKFRNPIILASGPVGFGFELMPYLDFSNIGAITLKTVTLKPREGNPPPRL-- 61 Query: 103 LVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKI 162 + G+IN +G N G++ VE + + I IG + D++ I E++ Sbjct: 62 VDSHGGVINSIGLQNPGIEGFVEEIAP-RLKELKTIKIG----SIAGFSMDEWEILGEEM 116 Query: 163 YAYAGYIAI--NISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAP 220 I N+S PN G R L + + I K PI K+AP Sbjct: 117 DKIKEIKIIEINLSCPNVKGKRRWAEDAKLTEKVVKIVRKLT--------GKPIIAKLAP 168 Query: 221 DLSEEELIQVADSLVRHNIDGVIATNTT--LDRSLVQGMKNCD-QTGGLSGRPLQLKSTE 277 D+++ ++++A + V DG+ N + + G+ +TGGL G ++ + Sbjct: 169 DVTD--IVEIAKTAVDAGADGLTIGNGAQAMRIDVETGLPILKLKTGGLGGPAVKPITLA 226 Query: 278 IIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + + L+ +PIIG+GGI + A E AGASL+ + + + P I+ I Sbjct: 227 KVFKTREALD--VPIIGIGGIMNWQDAIEYAMAGASLLGLGTA-VMVDPEAPVRIIEGI 282 >UniRef50_B1I4M6 Dihydroorotate dehydrogenase n=73 Tax=Bacteria RepID=PYRD_DESAP Length = 307 Score = 206 bits (525), Expect = 8e-52, Method: Composition-based stats. Identities = 68/283 (24%), Positives = 127/283 (44%), Gaps = 28/283 (9%) Query: 46 PVNCMGLTFKNPLGLAAGLDKDGE-CIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLV 104 V GLT KNP+ A+G GE L G G++ + TVT +P+ GN PR+ Sbjct: 6 AVAIAGLTLKNPVLTASGTVGFGEEYAPYLDLAGLGALVVKTVTLKPRAGNPPPRITE-- 63 Query: 105 DAEGLINRMGFNNLGVDNLVENV--KKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKI 162 G+IN +G N GV+ LV ++ + A +D + ++I + D+Y ++ Sbjct: 64 TPAGVINAVGLQNPGVEALVRDILPRLARFDVPVIVSIA-------GETVDEYARLAGRL 116 Query: 163 Y--AYAGYIAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKI 218 + +NIS PN G+ ++ ++ + +P+ K+ Sbjct: 117 DGVPGIAALEVNISCPNVKAGGIAFGTEPAMTAAVVRQVRE---------NTRLPVIAKL 167 Query: 219 APDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKN-CDQTGGLSGRPLQLKSTE 277 +P++++ I +A + + +I T + + + + + GGLSG ++ + Sbjct: 168 SPNVTDIRTIALAAAGAGADALSLINTLSAMVIDVERRRPLLGNVFGGLSGPAVRPVAVR 227 Query: 278 IIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSG 320 + ++ + LP+IG+GGI + A E I AGA V + + Sbjct: 228 AVWQVYQAV--ELPLIGMGGIMTARDALEFILAGARAVAVGTA 268 >UniRef50_B9TAL5 Dihydroorotate dehydrogenase, putative n=1 Tax=Ricinus communis RepID=B9TAL5_RICCO Length = 309 Score = 206 bits (525), Expect = 8e-52, Method: Composition-based stats. Identities = 90/338 (26%), Positives = 152/338 (44%), Gaps = 57/338 (16%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 +Y R +L+P+RA L+ + A ++ +GL F P+GL Sbjct: 20 LYETIAR----RLEPQRARSLAILALQLASVFKKNAT----TSSRSTEVLGLRFPGPVGL 71 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAG DK+GE L + GFG EIGTVT P+PG +LG+ Sbjct: 72 AAGFDKNGELYRYLPSAGFGFAEIGTVTLLPEPGR---------------------SLGI 110 Query: 121 DNLVENVKKAHYDG--VLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNT 178 + ++ + LG++I N+ T + DYL C+ + +A Y+ +N+ Sbjct: 111 HAVANSLARHARGHHIPLGLSISMNRATRPQAMAQDYLACLRAAWQHADYVVLNLGVRAG 170 Query: 179 PGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHN 238 P L ++ L D+L A++ ++ L +P +K+ D + Q+ D ++ Sbjct: 171 PDLHQPEHRNVLADVLEAVRTEKEVLFRQFGYRLPTMIKL--DQARGGTQQLMDMALKAG 228 Query: 239 IDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGI 298 I+GV+ G RP T ++ ++ L GR+PI+ VGGI Sbjct: 229 IEGVVLC-------------------GAGSRP-----TTLLEQMVKTLAGRIPIVAVGGI 264 Query: 299 DSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + A +++AAGASLVQ+++G + GP LI ++ + Sbjct: 265 RTPQDAADRLAAGASLVQVHTGLMQSGPKLISQMNAFL 302 >UniRef50_B1GYY3 Dihydroorotate dehydrogenase n=1 Tax=uncultured Termite group 1 bacterium phylotype Rs-D17 RepID=PYRD_UNCTG Length = 306 Score = 206 bits (525), Expect = 9e-52, Method: Composition-based stats. Identities = 67/281 (23%), Positives = 118/281 (41%), Gaps = 30/281 (10%) Query: 42 VPAKPVNCMGLTFKNPLGLAAGLDKDG-ECIDALGAMGFGSIEIGTVTPRPQPGNDKPRL 100 +P VN G+ KNP+ A+G G E D + G + TVT P+ GN +PR+ Sbjct: 2 IPDLSVNFAGIKLKNPVLTASGTFGYGYELADLIPLKRLGGVVTKTVTLEPRAGNLQPRI 61 Query: 101 FRLVDAEGLINRMGFNNLGVDNLVEN--VKKAHYDGVLGINIGKNKDTPVEQGKDDYLIC 158 + G++N +G N+GV +E K + +++ +Y+ Sbjct: 62 AEVAS--GILNSIGLQNIGVRAFIEEPLEKLNKIGVPVIVSVA-------GVAVGEYVEI 112 Query: 159 MEKIYAY--AGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAV 216 ++ + + I +N+S PN + D++ +K VP+ Sbjct: 113 VKILSSQNGVSAIELNLSCPNLKKKIVCHDLPLMRDVIRGVKKV---------SRVPVIA 163 Query: 217 KIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLV---QGMKNCDQTGGLSGRPLQL 273 K++P +++ + ++A + DGV TNT ++ K GG+SG ++ Sbjct: 164 KLSPLVTD--ISELALTAQNAGADGVTLTNTYPAMAVDIRTFKPKLSTVKGGMSGACIKP 221 Query: 274 KSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASL 314 S + + ++PIIG GGI A E I AGA+ Sbjct: 222 MSVRCVYDAYQ--DIKIPIIGCGGIMMGEDAVEFILAGATA 260 >UniRef50_D1JFH0 Dihydroorotate dehydrogenase electron transfer subunit/dihydroorotate dehydrogenase n=1 Tax=uncultured archaeon RepID=D1JFH0_9ARCH Length = 589 Score = 205 bits (521), Expect = 2e-51, Method: Composition-based stats. Identities = 77/315 (24%), Positives = 126/315 (40%), Gaps = 27/315 (8%) Query: 29 ITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVT 88 + TP + P G+ F NP+ AAG G+ + G G++ +V Sbjct: 273 LLSTPPARFTPEHEPELATEVCGIIFTNPIANAAGFGLSGKLLYRYAVAGAGAVVTKSVG 332 Query: 89 PRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKKAHY-DGVLGINI-GKNKDT 146 Q G P + +N MG N G+ + + A Y D L ++I GKN + Sbjct: 333 LYEQEGYPNPTFIEIA-PRSYVNAMGLPNPGIIDYGLEIGDAKYADVPLILSIFGKNVEE 391 Query: 147 PVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQA 206 E K + Y + N S P++ + + L ++ I+ Sbjct: 392 CREVAK------IATKYP-IDMLEFNASCPHSDFVAVENQPKLLRSIIKEIRAIV----- 439 Query: 207 MHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQG-----MKNCD 261 PIAVKI+P++ + +A +L + D + A NT + R + + N Sbjct: 440 ---HPKPIAVKISPNVGDP--AGLAMTLEKAGADAITAINTVIARPVDNRLDTHILGNPT 494 Query: 262 QTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGF 321 GG SG+ L + EI+ L EL ++PII VGGI S + GAS+ Q+ S Sbjct: 495 GYGGKSGKDLTVGGKEIVFNLYKEL--KIPIIAVGGIFSAKDVIDYAKNGASMFQVGSAL 552 Query: 322 IFKGPPLIKEIVTHI 336 + + + I + Sbjct: 553 VSEDLEIFSTIKKEL 567 >UniRef50_Q0B324 Dihydroorotate oxidase B, catalytic subunit n=8 Tax=Proteobacteria RepID=Q0B324_BURCM Length = 325 Score = 203 bits (517), Expect = 7e-51, Method: Composition-based stats. Identities = 72/300 (24%), Positives = 132/300 (44%), Gaps = 26/300 (8%) Query: 42 VPAKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLF 101 + V L +NP+ A+G E DAL G G++ I +V+P +PGN PR+ Sbjct: 1 MADLSVRVGELRLRNPVMPASGCFA-IEYRDALDLTGLGALVIKSVSPVSRPGNPTPRVA 59 Query: 102 RLVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEK 161 +G++N +G + G+D+ +E+V A+ + + DT + + Sbjct: 60 --DAGDGMLNSIGIPSRGIDDYLEHVLPAYTGHGTPVVASVSADTADAFARACEALSR-- 115 Query: 162 IYAYAGYIAINISSPN--TPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIA 219 I NIS PN G+ ++ AI+ + P+ VK+ Sbjct: 116 --PDVAAIEANISCPNLEADGMAFGMDAGMTRQVVDAIRTRTGH---------PLWVKLT 164 Query: 220 PDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKN---CDQTGGLSGRPLQLKST 276 P+ + ++A + D ++ NT L S+ + + GGLSG ++ + Sbjct: 165 PN--AGNIAKIAQAAQDAGADAIVMGNTVLGMSIDVRTRRPSLGNVMGGLSGPSIKPIAL 222 Query: 277 EIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 ++ + ++ +P+IG GGI S A E + AGAS VQ+ + F+ P +++ I+ + Sbjct: 223 RLVHQCYRAVS--IPVIGCGGIRSAADAIEFLLAGASAVQVGTA-SFRDPGVMRTIIDGL 279 >UniRef50_D1YYV3 Dihydroorotate dehydrogenase n=1 Tax=Methanocella paludicola SANAE RepID=D1YYV3_METPS Length = 315 Score = 203 bits (517), Expect = 8e-51, Method: Composition-based stats. Identities = 72/305 (23%), Positives = 126/305 (41%), Gaps = 29/305 (9%) Query: 38 VRQKVPAKPVNCMGLTFKNPLGLAAG-LDKDGECIDALGAMGFGSIEIGTVTPRPQPGND 96 ++ V GLT NP LAAG L G + + +MG G++ ++ P+ G+ Sbjct: 5 LKNDTMKLTVEAGGLTLTNPTILAAGILGTTGASLKRVASMGAGAVVTKSIGAEPKYGHP 64 Query: 97 KPRLFRLVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYL 156 P + RL G IN MG N + ++ A GV I + + Sbjct: 65 NPSMIRL--ECGYINAMGLPNPSYKEFLPELETAKDSGVPVI-------ASIFGATEAEF 115 Query: 157 ICMEKIYAYAGYIAINISSPNTPG--LRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPI 214 I + K A +N+S P+ G ++ + + A+K N P+ Sbjct: 116 IEVAKGLPGASAYELNVSCPHARGYGMQVGTDPALVKAIAHAVKGTVNA---------PV 166 Query: 215 AVKIAPDLSEEELIQVADSLVRHNIDGVIATNT--TLDRSLVQGMK-NCDQTGGLSGRPL 271 VK+ P++++ + + + D V+A NT + + G + GGLSG + Sbjct: 167 WVKLTPNVTD--ITSIGRAAQEGGADAVVAINTLKAIAIDIDSGYPILGNIQGGLSGPAI 224 Query: 272 QLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKE 331 + + + L L+ +P+IG GG+ S A E I AGA+ V+I S ++ + Sbjct: 225 KPVAVRCVYDLYSALD--IPVIGAGGVSSWADAVEFIMAGAAAVEIGSA-VYDDIGVFAA 281 Query: 332 IVTHI 336 + + Sbjct: 282 VSMGL 286 >UniRef50_C2D6B3 Dihydroorotate oxidase n=1 Tax=Atopobium vaginae DSM 15829 RepID=C2D6B3_9ACTN Length = 309 Score = 203 bits (516), Expect = 8e-51, Method: Composition-based stats. Identities = 70/300 (23%), Positives = 123/300 (41%), Gaps = 25/300 (8%) Query: 44 AKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMG-FGSIEIGTVTPRPQPGNDKPRLFR 102 + VN G+ KNP+ AAG G+ + + G+I + +P GN PR+ Sbjct: 7 SMEVNLGGIHMKNPVNTAAGTFAFGQQFEKFYDVSQLGAITTKGASIKPWAGNPAPRMCE 66 Query: 103 LVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKI 162 + G+IN +G N GV+ L+ N A+ G+ N + D+Y+ +E Sbjct: 67 VTS--GIINSVGLQNPGVNGLI-NTAGAYLTGLQQKN-CQVICQVAGHSIDEYVAALEVF 122 Query: 163 YAYAGY---IAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIA 219 A + INIS PN G A+ L+ + + P+ VK+ Sbjct: 123 EEKASFAAGFEINISCPNIA-----CGGAAMGSTPQGAAEIMRRLRPLTKR--PLLVKMG 175 Query: 220 PDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQ---GMKNCDQTGGLSGRPLQLKST 276 P + ++A +L D + N+ ++ K TGG SG + + Sbjct: 176 P----VNIPEIARALESEGADALSLINSIPGMAIDTTTYKSKLSRPTGGFSGPAIHPIAV 231 Query: 277 EIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 ++ + ++P+ G+GGI + + A E I AGA+ V + ++ P I+ + Sbjct: 232 RMVWEAHKAV--KIPLCGIGGITTGLEAAEFILAGATAVSVGLANLYD-PMSAPRILHEL 288 >UniRef50_Q1MQG1 Dihydroorotate dehydrogenase n=2 Tax=Deltaproteobacteria RepID=Q1MQG1_LAWIP Length = 314 Score = 203 bits (516), Expect = 1e-50, Method: Composition-based stats. Identities = 61/295 (20%), Positives = 117/295 (39%), Gaps = 32/295 (10%) Query: 52 LTFKNPLGLAAGLDKDG-ECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLI 110 L KNP+ A+G G E I G I + ++ +P+ GN PR+ G++ Sbjct: 20 LVLKNPVLTASGTFGYGAEFIGYGDLSQLGGIIVKGLSLKPRKGNPLPRIAE--TPCGML 77 Query: 111 NRMGFNNLGVDNLVEN--VKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAY--A 166 N +G N GV+ ++ + + + N+ +++ + A Sbjct: 78 NTIGLQNDGVELFIQKKLPRLPWKETPVIANL-------YATSVEEFSELTAILAAEEGV 130 Query: 167 GYIAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSE 224 + +N+S PN G Q + A+ + P+ VK++P++++ Sbjct: 131 AALEVNVSCPNVKSGGTFFGQDPSLAAKVTEAV--------CKNAGSKPVMVKLSPNVTD 182 Query: 225 EELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNC---DQTGGLSGRPLQLKSTEIIRR 281 + +A ++ D + NT ++ + GGLSG ++ + + Sbjct: 183 ITI--IAKAVESAGADAISCINTLTGMAVDIRKRKSLLSTVIGGLSGPGIKPIALRCVWE 240 Query: 282 LSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + +N +P+IG+GGI S E I GA VQI + + P + I + Sbjct: 241 VCKAVN--IPVIGIGGITSARDVLEFILVGAHAVQIGTMNFIQ-PDIAFRIAEAL 292 >UniRef50_C1A4J6 Dihydroorotate dehydrogenase n=1 Tax=Gemmatimonas aurantiaca T-27 RepID=C1A4J6_GEMAT Length = 327 Score = 202 bits (515), Expect = 1e-50, Method: Composition-based stats. Identities = 75/303 (24%), Positives = 124/303 (40%), Gaps = 33/303 (10%) Query: 46 PVNCMGLTFKNPLGLAAGLDKDG-ECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLV 104 V+ GL F+NP+ LA+G G E D L G I V+ P+PGN R+ Sbjct: 23 SVSVAGLAFRNPVVLASGTAGFGQELEDVLDLSAVGGISTKAVSVAPRPGNPALRVSEFA 82 Query: 105 DAEGLINRMGFNNLGVDNLVEN----VKKAHYDGVLGINIGKNKDTPVEQGKDDYLICME 160 G++N +G N G++++ + + H + +N+ N +D+ + Sbjct: 83 --GGMMNAIGLANPGLESVRRDYLPWLPAHHPGTRVFVNVVGN-------SIEDFATVVR 133 Query: 161 KIY--AYAGYIAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAV 216 + +N+S PN GL +AL L++A + PI V Sbjct: 134 GLDDVPGVDAFELNVSCPNVKAGGLEFGADPQALHALVSAARGATKR---------PIFV 184 Query: 217 KIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCD---QTGGLSGRPLQL 273 K++P L + A V G+ NT + + +GG+SG L Sbjct: 185 KLSPTLG-AAIADTARVAVDAGATGLTLVNTMPGTVIDTDRRRPKLSFGSGGVSGPALLP 243 Query: 274 KSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIV 333 R+S L +P+IG+GGI + A + + AGASLV + + + P + IV Sbjct: 244 VGLLATWRVSRAL-PTVPLIGLGGISTGDDALQYLMAGASLVGVGTA-ALRDPRAPERIV 301 Query: 334 THI 336 + Sbjct: 302 RQL 304 >UniRef50_Q3B2I1 Dihydroorotate oxidase B, catalytic subunit n=12 Tax=Chlorobiaceae RepID=Q3B2I1_PELLD Length = 331 Score = 200 bits (510), Expect = 5e-50, Method: Composition-based stats. Identities = 72/292 (24%), Positives = 135/292 (46%), Gaps = 25/292 (8%) Query: 51 GLTFKNPLGLAAGLDKDGECIDALGAMG-FGSIEIGTVTPRPQPGNDKPRLFRLVDAEGL 109 GL+ K+P+ LA+G GE + L + G I ++ + GN R+ G+ Sbjct: 37 GLSLKSPVMLASGTVSYGEELCRLTDLSKIGGIVTKAISLEARAGNPPQRIAE--TPSGM 94 Query: 110 INRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYA--G 167 IN +G N+G+D + K + LG I N + D+Y + ++ A Sbjct: 95 INAIGLANVGIDRFISE--KVPFLQTLGTAIVVNI---AGRSIDEYAEVVSRLDAVPGLD 149 Query: 168 YIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEEL 227 IN+S PN G + G + D A + +L+++ ++ + +K+ P+++ + Sbjct: 150 GYEINLSCPNVKG-ECMIMGVSPD----ATREIVTELRSITGRH--LMIKLTPNVTS--I 200 Query: 228 IQVADSLVRHNIDGVIATNTTLDRSLVQGMKN---CDQTGGLSGRPLQLKSTEIIRRLSL 284 +A + + D V NT + ++ + + TGGLSG ++ + + ++ Sbjct: 201 SAIAIAAEKAGADSVSLINTLVGMAIDWKKRRPLLKNVTGGLSGPAIKPVALAKVWEVNN 260 Query: 285 ELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 ++ +PI+G+GGI S A E + AGA VQI + F P + ++I T + Sbjct: 261 AVS--IPIVGMGGIASFDDAMEFLVAGAGAVQIGT-MNFVQPDIGEKIATAM 309 >UniRef50_Q3J7C7 Dihydroorotate oxidase B, catalytic subunit n=10 Tax=Proteobacteria RepID=Q3J7C7_NITOC Length = 331 Score = 200 bits (508), Expect = 7e-50, Method: Composition-based stats. Identities = 67/312 (21%), Positives = 123/312 (39%), Gaps = 33/312 (10%) Query: 37 LVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDGEC---IDALGAMGFGSIEIGTVTPRPQP 93 L V+ GL ++PL L +G GE + G++ + T P+ Sbjct: 9 LSDTDWARLKVDFCGLELQSPLVLLSGCVGFGEEYTRVVGFSNREVGAVCLKGTTAAPRL 68 Query: 94 GNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKKA--HYDGVLGINIGKNKDTPVEQG 151 GN R++ G++N +G N GVD +V+++ A + N+ + Sbjct: 69 GNALHRIYE--TPMGMLNAIGLQNPGVDYVVDHILPALDFSETRYIANVSGST------- 119 Query: 152 KDDYLICMEKIY-AYAGYIAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMH 208 ++Y + + I INIS PN G+ ++ A + Sbjct: 120 IEEYTAVTRRFDNSPIDAIEINISCPNVKEGGVAFGNDPHMSARVVEACRKVTRK----- 174 Query: 209 HKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKN---CDQTGG 265 P+ K++P+ + + + A + DG NT + ++ + + GG Sbjct: 175 ----PLITKLSPNQTS--IEENARRCIEAGTDGFAVINTLMGMAIDIEQRTPLLGNIQGG 228 Query: 266 LSGRPLQLKSTEIIRRLSLELNGR-LPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFK 324 LSG ++ + +R++ +PIIG GG+ S A E + AGA+ V + + + Sbjct: 229 LSGPAIKPIALLKVRQVYQACRAHGIPIIGQGGVASGKDALEFLIAGATTVGVGTALFYD 288 Query: 325 GPPLIKEIVTHI 336 P L +I I Sbjct: 289 -PLLCAKINAEI 299 >UniRef50_B8D3W9 Dihydroorotate dehydrogenase, PyrD n=1 Tax=Desulfurococcus kamchatkensis 1221n RepID=B8D3W9_DESK1 Length = 302 Score = 198 bits (505), Expect = 2e-49, Method: Composition-based stats. Identities = 70/298 (23%), Positives = 127/298 (42%), Gaps = 27/298 (9%) Query: 45 KPVNCMGLTFKNPLGLAAG-LDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRL 103 + GL K+P+ A+G L + E ++ L GF ++ T+T P+ G P + L Sbjct: 5 LETSIAGLRLKHPVMNASGILGSEPEHLEILAKQGFSALVSKTITLNPREGYPPPIIVEL 64 Query: 104 VDAEGLINRMGFNNLGVDNLVENVKKAH-YDGVLGINIGKNKDTPVEQGKDDYLICMEKI 162 + GL+N +G N G + +KA L ++IG + ++++ E Sbjct: 65 RNN-GLLNAVGLANPGARVIPVLARKARELSKPLILSIGGS-------SVEEFVKLAELA 116 Query: 163 Y-AYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPD 221 A + +N+S P+ G YG L + D A+ +P+ K+ Sbjct: 117 SEAGVDAVELNLSCPHAEG-----YGLELGSDPMLVYRIVKD--AVSVASLPVIAKLGL- 168 Query: 222 LSEEELIQVADSLVRHNIDGVIATNTTLDRSLV---QGMKNCDQTGGLSGRPLQLKSTEI 278 + +I+ A + + + NT S+ ++ GGLSG P+ + + Sbjct: 169 --TDRVIESAGKALEAGVKALTLINTVKAMSIDVYTLKPVLSNKYGGLSGPPIHPIAVRV 226 Query: 279 IRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + + E IIGVGG+ S + E I AGA VQ+ + I+ ++ EI++ + Sbjct: 227 VYDVYREYRAE--IIGVGGVSSWMDVAELILAGARAVQVGTALIWN-ENIVDEILSGL 281 >UniRef50_C5R8W8 Dihydroorotate dehydrogenase B, catalytic subunit n=1 Tax=Weissella paramesenteroides ATCC 33313 RepID=C5R8W8_WEIPA Length = 323 Score = 198 bits (505), Expect = 2e-49, Method: Composition-based stats. Identities = 69/283 (24%), Positives = 125/283 (44%), Gaps = 30/283 (10%) Query: 46 PVNCMGLTFKNPLGLAAGLDKDG-ECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLV 104 V+ GL KNP ++G G + +D G++ + T T P+ GN +P + + Sbjct: 7 AVSLPGLKLKNPFMPSSGAFYYGLDHMDDFDLNKLGALVLKTTTLAPRTGNPQPWI--VN 64 Query: 105 DAEGLINRMGFNNLGVDN----LVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICME 160 G++N +G N G+ + + D ++I D+++ + Sbjct: 65 TKAGILNSVGLANPGIAAVKADFLPELAAKLPDLPKMLSIS-------GATVDEFVQLAK 117 Query: 161 KIY--AYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKI 218 I I +N+S PN + G A + I + + ++A+ K I K+ Sbjct: 118 IIDKLPAINAIELNLSCPNVD-----EGGCAFGVTESGIHSVVSAVRAVTTKA--IYAKL 170 Query: 219 APDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCD---QTGGLSGRPLQLKS 275 +P++++ + +A + DG+ NT + SL ++ GGLSG L + Sbjct: 171 SPNVTD--IKPLAVTAENAGADGLTMVNTLVGMSLDLQSRSARLYRGKGGLSGEALHPLA 228 Query: 276 TEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIY 318 E+I + ++ +PIIGVGG+ S+ A E + AGAS VQ+ Sbjct: 229 VELIWEAASAVH--IPIIGVGGVSSIDDALELMMAGASAVQVG 269 >UniRef50_P28272 Dihydroorotate dehydrogenase n=168 Tax=cellular organisms RepID=PYRD_YEAST Length = 314 Score = 197 bits (502), Expect = 4e-49, Method: Composition-based stats. Identities = 68/304 (22%), Positives = 117/304 (38%), Gaps = 22/304 (7%) Query: 42 VPAKPVNCMGLTFKNPLGLAAGLD-KDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRL 100 + + T++NP A+G+ + +D L G+ + T + GN +PR Sbjct: 2 TASLTTKFLNNTYENPFMNASGVHCMTTQELDELANSKAGAFITKSATTLEREGNPEPRY 61 Query: 101 FRLVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICME 160 + G IN MG N G+D + V + I + D+ L + Sbjct: 62 ISVP--LGSINSMGLPNEGIDYYLSYVLNRQKNYPDAPAI---FFSVAGMSIDENLNLLR 116 Query: 161 KI--YAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKI 218 KI + G +N+S PN PG + Y L K + A K P+ VK+ Sbjct: 117 KIQDSEFNGITELNLSCPNVPGKPQVAYDFDLT------KETLEKVFAFFKK--PLGVKL 168 Query: 219 APDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQG------MKNCDQTGGLSGRPLQ 272 P +A L + V + N+ + + +K + GG+ G ++ Sbjct: 169 PPYFDFAHFDIMAKILNEFPLAYVNSINSIGNGLFIDVEKESVVVKPKNGFGGIGGEYVK 228 Query: 273 LKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 + +R L + +IG GGI S A E + GAS++QI + +G + + I Sbjct: 229 PTALANVRAFYTRLRPEIKVIGTGGIKSGKDAFEHLLCGASMLQIGTELQKEGVKIFERI 288 Query: 333 VTHI 336 + Sbjct: 289 EKEL 292 >UniRef50_A0NIQ6 Dihydroorotate dehydrogenase A n=7 Tax=Lactobacillales RepID=A0NIQ6_OENOE Length = 329 Score = 195 bits (497), Expect = 2e-48, Method: Composition-based stats. Identities = 68/302 (22%), Positives = 125/302 (41%), Gaps = 29/302 (9%) Query: 47 VNCMGLTFKNPLGLAAGLDKDGECIDALGAM----GFGSIEIGTVTPRPQPGNDKPRLFR 102 F + AAG+ + ++ L + G++ + T + + GN +PR F Sbjct: 22 TKIANQVFHHLFINAAGV--YCQTVEELEQIQNAPCAGAVITKSATAKERSGNSEPRYFE 79 Query: 103 LVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKI 162 IN MG NLG+D + V K +I V + + + ++K+ Sbjct: 80 NSVEHNTINSMGLPNLGIDYYLNYVLKHSLKLPTLFSI-------VGLSQSEIIDNLKKL 132 Query: 163 YA--YAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAP 220 A ++G +N+S PN PG + Y TA + +++ A + K P+ VK+ P Sbjct: 133 QASGFSGLTELNLSCPNVPGKPQIAY------DFTATREILDNVFAFYSK--PLGVKLPP 184 Query: 221 DLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQG------MKNCDQTGGLSGRPLQLK 274 Q+A L + + V A N+ + ++ +K D GGL G+ ++ Sbjct: 185 YFDTAHFDQIASILNDYPLTYVNAINSVGNGLVIDPETDTPVIKPKDGFGGLGGKQIKAT 244 Query: 275 STEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVT 334 + +R L L ++ II GG+ + + + GA L+ I S +GP + + Sbjct: 245 ALANVRALRQRLYPQIKIIATGGVTNGRDVYDHLLCGADLISIGSQLEIEGPTVFARLEK 304 Query: 335 HI 336 + Sbjct: 305 EL 306 >UniRef50_O29513 Dihydroorotate dehydrogenase n=3 Tax=Archaeoglobaceae RepID=PYRD_ARCFU Length = 299 Score = 194 bits (493), Expect = 4e-48, Method: Composition-based stats. Identities = 64/284 (22%), Positives = 113/284 (39%), Gaps = 25/284 (8%) Query: 45 KPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLV 104 GL KNPL LA+G+ L A G++ +V + G P + + Sbjct: 4 LETEIGGLRMKNPLMLASGIMGSKVHSLNLIARDAGAVVTKSVGVEEREGYRNPTV--VN 61 Query: 105 DAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYA 164 GLIN +G + + E +K + L I++ + D + + Sbjct: 62 WKCGLINAVGLASPAAKDFAEELKDYTNEAPLLISLYGHSVEEF----SDLVDTFDSALP 117 Query: 165 YAGYIAINISSPNTPG--LRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDL 222 Y +N+S P+ G L E ++ +K K + P+ K++ Sbjct: 118 YLHGYELNLSCPHVKGAGLDIGMDLELSAAIVEELKGKTKN---------PVFAKLS--- 165 Query: 223 SEEELIQVADSLVRHNIDGVIATNTTLDRSLVQ---GMKNCDQTGGLSGRPLQLKSTEII 279 + + +++A L +DG+ +NT + + +GG+SG ++ + + + Sbjct: 166 AMHDYLKLAKVLEDAGVDGITISNTLRGMKIDIMSGKPVLSNLSGGVSGPAIKPIALKCV 225 Query: 280 RRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIF 323 L E+ +PI+G GGI S E I AGA VQI S + Sbjct: 226 YDLYKEI--EVPIVGCGGITSFEDVLEFIMAGARAVQIGSAVYY 267 >UniRef50_Q1Q4L5 Similar to dihydroorotate oxidase (Dihydroorotate dehydrogenase B) catalytic subunit n=1 Tax=Candidatus Kuenenia stuttgartiensis RepID=Q1Q4L5_9BACT Length = 306 Score = 194 bits (493), Expect = 5e-48, Method: Composition-based stats. Identities = 72/302 (23%), Positives = 133/302 (44%), Gaps = 30/302 (9%) Query: 44 AKPVNCMGLTFKNPLGLAAG-LDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFR 102 +N + NP LA+G L + + G G++ I +V+ + G+ P + Sbjct: 5 TLSINLCSMRLSNPTVLASGILGTTKTLLKRVAESGAGAVTIKSVSKDSREGHHNPTVIT 64 Query: 103 LVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKI 162 G++N +G++N GV+ + GV I + + DD++ E + Sbjct: 65 Y--EAGMLNAVGYSNPGVEAARIEYSNLNEIGVPVIA------SIIGTCTDDFIEVAEGL 116 Query: 163 YAYA-GYIAINISSPNTPGLRTLQY---GEALDDLLTAIKNKQNDLQAMHHKYVPIAVKI 218 A I I +S P+TPG L +A ++ A++ K N VPI VKI Sbjct: 117 SASGFSAIEIPLSCPHTPGFGLLSGQGTPKATYEITYAVRRKTN---------VPIFVKI 167 Query: 219 APDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLV----QGMKNCDQTGGLSGRPLQLK 274 +P++ E + +A + +G+ A N+ ++ + + GG++G L+ Sbjct: 168 SPNVPE--ITSIAKAAEDAGANGITAVNSMGPGMVINIESKKPVLGFKVGGVTGDALRPI 225 Query: 275 STEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVT 334 + + + + ++PIIGVGGI + A E + AGAS V I +G +G + ++ Sbjct: 226 AVRCVYDVYQAV--KIPIIGVGGISTGRHAIEMMMAGASAVGIGTGVYTRGINVFSKVCA 283 Query: 335 HI 336 + Sbjct: 284 EM 285 >UniRef50_D2RBF2 Dihydroorotate dehydrogenase 1B n=21 Tax=Bifidobacteriaceae RepID=D2RBF2_GARVA Length = 333 Score = 193 bits (491), Expect = 8e-48, Method: Composition-based stats. Identities = 77/302 (25%), Positives = 125/302 (41%), Gaps = 26/302 (8%) Query: 41 KVPAKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRL 100 V P G+ +KN +G A+G + C G+I V+P P GN PR Sbjct: 31 HVWKHPTQVAGVKWKNMVGTASGTFQLAACRRFYDVSQLGAICTKGVSPVPWEGNPSPRT 90 Query: 101 FRLVDAEGLINRMGFNNLGVD-NLVENVKKAHYDGVLGI-NIGKNKDTPVEQGKDDYLIC 158 G++N +G N GVD LV+ + K G L I N+ + D DDY Sbjct: 91 AE--SPSGMVNAVGLQNPGVDHYLVDELPKLKKMGALVITNVAGHSD-------DDYAQV 141 Query: 159 MEKIYA-YAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVK 217 +EK+ A + IN+S PN G ++ A+ L+AM K P+ VK Sbjct: 142 VEKLADSAADMLEINVSCPNV-----THGGMSVGTDPVALHRLIKRLRAMTDK--PMIVK 194 Query: 218 IAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMK---NCDQTGGLSGRPLQLK 274 + P++++ ++ + + V D + NT + + ++TGG+SG + Sbjct: 195 MTPNVTD--IVSICKAAVDAGADALSMINTLVGLRIDIRTGEPIIANRTGGVSGPAIFPI 252 Query: 275 STEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVT 334 + R+ + I G IDS A E + AGA+ V++ + P I Sbjct: 253 GLGFVWRVRQAMPDIPIIGIGG-IDSGEKALEYLYAGANAVEVGAA-ALVDPTAPIRIAR 310 Query: 335 HI 336 + Sbjct: 311 EL 312 >UniRef50_C1TMB2 Dihydroorotate dehydrogenase family protein n=1 Tax=Dethiosulfovibrio peptidovorans DSM 11002 RepID=C1TMB2_9BACT Length = 304 Score = 191 bits (485), Expect = 4e-47, Method: Composition-based stats. Identities = 63/297 (21%), Positives = 124/297 (41%), Gaps = 20/297 (6%) Query: 44 AKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMG-FGSIEIGTVTPRPQPGNDKPRLFR 102 VN + ++P+ +A+G E + + G++ +T P+ GN R++ Sbjct: 3 DLSVNIGSVPLRSPVIIASGTWGYDESLWREDLLRHVGAVCSKAITESPKDGNPGHRIWE 62 Query: 103 LVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKI 162 GL+N +G N G+D+ V+ K G+ I N E+G + + ++ Sbjct: 63 --TPCGLLNSIGLQNTGIDDFVDE--KIPKLKSYGVPIIANVSMEDERGLALIVERLVEV 118 Query: 163 YAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDL 222 I +N+S PN + +G ++ + Q P+ VK+ P Sbjct: 119 ADCVDAIELNVSCPNV-DKGCMSWG------VSPVLTSQAVSMVQKIWKGPLWVKMTPQA 171 Query: 223 SEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNC---DQTGGLSGRPLQLKSTEII 279 + E VA + D ++ NT L ++ + G SG + + ++ Sbjct: 172 PDPE--GVARAAEDSGADALVVANTWLGMAIDVDSRKAVFDRVVAGFSGPAVFPMALRLV 229 Query: 280 RRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 ++S ++ +P+IG GG+ S I AGA+ V++ +G +F+ L + I+ + Sbjct: 230 WQVSSAVS--IPVIGCGGVSSGRDLLSMIMAGATAVELGTG-MFRDIRLPENILREV 283 >UniRef50_Q8TXU6 Dihydroorotate dehydrogenase n=1 Tax=Methanopyrus kandleri RepID=Q8TXU6_METKA Length = 318 Score = 190 bits (484), Expect = 5e-47, Method: Composition-based stats. Identities = 69/281 (24%), Positives = 118/281 (41%), Gaps = 16/281 (5%) Query: 45 KPVNCMGLTFKNPLGLAAG-LDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRL 103 +PV +G + +P+ A+G L ++ G +I TVT P+ G+ P Sbjct: 2 RPVEVLGKRWAHPIACASGALAAHRPGMENAVLRGAAAIFTKTVTESPREGHPGPVFVDY 61 Query: 104 VDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIY 163 +D +N MG N G D +V +++ + + + D P + + Sbjct: 62 LDEGYALNAMGLPNPGPDRMVVEIEEFRDEFDVPVYASVAADGP-----EGFKRLARAFS 116 Query: 164 AYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLS 223 A + +N+S P+ YG L A+ A+ P++VK+ P++ Sbjct: 117 GVADGLELNVSCPHAGKG----YGAELGSDPEAVAEITE--AAVRAFDGPVSVKLTPNVD 170 Query: 224 EEELIQVADSLVRHNIDGVIATNTT---LDRSLVQGMKNCD-QTGGLSGRPLQLKSTEII 279 E L++VA + + + + A NT L L GGLSG L+ + ++ Sbjct: 171 RETLLEVAAAAIDAGAEALTAVNTLGPGLRIDLRTASPVLGAGVGGLSGPALKPIALRVV 230 Query: 280 RRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSG 320 L+LE + IIGVGGI + E + AGA VQ+ + Sbjct: 231 ADLALEFGEEVEIIGVGGIRNGEDVVEFLFAGAKAVQVATA 271 >UniRef50_A6BB63 Dihydroorotate dehydrogenase n=1 Tax=Vibrio parahaemolyticus AQ3810 RepID=A6BB63_VIBPA Length = 181 Score = 190 bits (483), Expect = 7e-47, Method: Composition-based stats. Identities = 91/156 (58%), Positives = 132/156 (84%) Query: 181 LRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNID 240 + ++YGEALD+LL+ +K KQ++L H KYVP+A+KIAPDLS++E+ Q+ +SL+++NID Sbjct: 26 IAQMEYGEALDELLSELKAKQSELAEKHGKYVPLALKIAPDLSDDEITQICESLLKNNID 85 Query: 241 GVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDS 300 GVIATNTTLDR++V+GMK+ ++ GGLSGRP+Q +STE++R+L L +LPIIGVGGIDS Sbjct: 86 GVIATNTTLDRTVVEGMKHANEAGGLSGRPVQSRSTEVVRKLHEALGDKLPIIGVGGIDS 145 Query: 301 VIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 +AA+EK+ AGA LVQ+Y+GFI+ GP L+++IV ++ Sbjct: 146 YVAAKEKMMAGAQLVQVYTGFIYHGPGLVRDIVKNL 181 >UniRef50_C9M6H2 Dihydroorotate oxidase n=2 Tax=Synergistaceae RepID=C9M6H2_9BACT Length = 317 Score = 189 bits (481), Expect = 9e-47, Method: Composition-based stats. Identities = 60/307 (19%), Positives = 123/307 (40%), Gaps = 34/307 (11%) Query: 41 KVPAKPVNCMGLTFKNPLGLAAGL---DKD---GECIDALGAMGFGSIEIGTVTPRPQPG 94 + + GL +PL +A+G+ +K+ GE +D G++ +T P+PG Sbjct: 3 SISKLTCHVGGLDLTSPLVIASGIWPYEKEYWAGEYLDF-----AGAVCSKAITADPRPG 57 Query: 95 NDKPRLFRLVDAEGLINRMGFNNLGVDNLVENV--KKAHYDGVLGINIGKNKDTPVEQGK 152 N R++ G++N +G N G + + Y L +N+ + +E+ Sbjct: 58 NPGTRVWE--TPCGMLNSIGLQNEGAGSFFGGTLGRLRSYGKPLLLNVSMESSSDLERIL 115 Query: 153 DDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYV 212 D ME + + +N+S PN + +G A++ + Sbjct: 116 D----AMEPVAPSVDCVELNVSCPNV-DQGCMSWGVDPALTAQAVQQVRR------RWSG 164 Query: 213 PIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQ---GMKNCDQTGGLSGR 269 P+ VK+ P + VA + ++ NT L ++ GLSG Sbjct: 165 PLWVKLTPQAPDP--CAVAKAAQDAGASALVVANTWLGAAIDTVKARPAFDRVVAGLSGP 222 Query: 270 PLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLI 329 + + ++ ++ ++ +P++G GG+ S +A + AGA+ V++ F ++ Sbjct: 223 AIFPLALRMVWQVCGAVD--IPVVGCGGVASADSAVAMLMAGAAAVEVGMAL-FSDFSVL 279 Query: 330 KEIVTHI 336 + I + Sbjct: 280 ERIARGL 286 >UniRef50_A8MCA1 Dihydroorotate oxidase n=1 Tax=Caldivirga maquilingensis IC-167 RepID=A8MCA1_CALMQ Length = 322 Score = 188 bits (477), Expect = 3e-46, Method: Composition-based stats. Identities = 81/341 (23%), Positives = 148/341 (43%), Gaps = 41/341 (12%) Query: 8 KALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKP--VNCMGLTFKNPLGLAAGLD 65 K L L P+ H+ T LR + + A P + + +P+G+ AG+D Sbjct: 5 KLLGYLPPDLTHDVTHLILRTYPVKVLIGTLTRLTGALPYRLRLLNRVIDSPIGIGAGID 64 Query: 66 KDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVE 125 KDG I + + G +G+VT +P+ GN KPR+ R + ++N MG + GVD L Sbjct: 65 KDGLLISLMSRLPIGFHIVGSVTLKPRRGNPKPRMRRYPGLDAMVNAMGLPSRGVDFLKG 124 Query: 126 NVK----KAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAY---AGYIAINISSPNT 178 + + +LG+++ +T ++ + ++ + Y +I IN+SSP Sbjct: 125 ILNNECVRWPRSKLLGVSVAGFSET-------EFKLLLDSLTPYMDCVDFIEINVSSPTY 177 Query: 179 PGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHN 238 G + L++LL ++K Y + +K+ S + +++ ++ HN Sbjct: 178 GG--SWTEPHRLNELLNSLK-----------GYDKLVIKLPLLSSINDEVKLIKLIINHN 224 Query: 239 IDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEII---RRLSLELNGRLPIIGV 295 G+ NT ++ + GGLSG+PL +I RR+ + Sbjct: 225 PFGLTIANTLSIKADLP-----MGYGGLSGKPLLGIVINLIKLTRRIGYGGLIIGLGGFM 279 Query: 296 GGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 GI + I A A L+ + +GF +GP ++ I+ + Sbjct: 280 RGI----DIIKGIKAEADLIGLVTGFAMEGPLVVYRIINEL 316 >UniRef50_A9D5Y9 Dihydroorotate dehydrogenase n=1 Tax=Shewanella benthica KT99 RepID=A9D5Y9_9GAMM Length = 334 Score = 187 bits (476), Expect = 5e-46, Method: Composition-based stats. Identities = 69/316 (21%), Positives = 117/316 (37%), Gaps = 29/316 (9%) Query: 34 FEALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDGE-CIDALGAMGFGSIEIGTVTPRPQ 92 EA+ R + + + A+G E ++ LGA +I + T P+ Sbjct: 13 IEAVNRCVNKRISTRIAQVPLASFIFNASGPRCTEEDELNLLGASASAAIMTKSCTLEPR 72 Query: 93 PGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKKAHY------DGVLGINIGKNKDT 146 GN +PR L G I MG NLG +E + + + + +++ Sbjct: 73 QGNAEPRYQALP--LGSIQSMGLPNLGYQAYLEMLPRLKQAISPQTNKPIVVSVSGFSLA 130 Query: 147 PVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQA 206 + + A I +N S PN G Q G + A++ Q Sbjct: 131 DNLTMVKAFQ------ASCADLIEVNFSCPNIEGKP--QVGYDFEQTERALE------QL 176 Query: 207 MHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQG------MKNC 260 PI +K+ P I +A+ + + + + N+ + ++ +K Sbjct: 177 CQLGSKPIGLKLPPYFDFSHFITMANIIKKFPVRFITCINSVGNTLVIDPETESAIIKPK 236 Query: 261 DQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSG 320 GGL G ++ +R S L + IIGVGGI + A E + AGAS VQ+ + Sbjct: 237 GGFGGLCGDYIKPIGLANVRAFSQLLPSSIDIIGVGGIKTGTDAFEYLLAGASAVQVATC 296 Query: 321 FIFKGPPLIKEIVTHI 336 F +G I + Sbjct: 297 FEKEGIECFDRIAKEL 312 >UniRef50_D0JBI0 Dihydroorotate dehydrogenase n=2 Tax=Blattabacterium RepID=D0JBI0_BLASB Length = 320 Score = 185 bits (469), Expect = 2e-45, Method: Composition-based stats. Identities = 68/301 (22%), Positives = 117/301 (38%), Gaps = 33/301 (10%) Query: 48 NCMGLTFKNPLGLAAG-LDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDA 106 G+ + + A+G L G+ + L G+I + T +P+ GN KPR F Sbjct: 18 RINGIQLSSCIMNASGALCTTGQELSDLLDSSSGAIVTKSCTRQPRKGNIKPRYFEW--N 75 Query: 107 EGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYA 166 G IN MG NLG+D + +++ + ++I + +L+ + Sbjct: 76 VGSINSMGLPNLGIDFYLNFLEEKKTKKPVFLSISGLSIEEIF-----FLLKKANFSSKI 130 Query: 167 GYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEE 226 I +N+S PN LQ E L L I + ++ + K P+ +K+ P EE Sbjct: 131 TAIELNLSCPN------LQE-EILGYDLYKIYDFLENVFKFNEK--PLGIKLPPYFKEEY 181 Query: 227 LIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRP-----------LQLKS 275 + ++ L + I V N+ + V +P ++ + Sbjct: 182 IKNMSLILNQFPIVFVTCINSLPNGIFVDPRNETSVI-----QPRNGFGGIGGSIIKPFA 236 Query: 276 TEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTH 335 IR+ L + IIG GGI E I GAS VQI + + +G + + + Sbjct: 237 LANIRKFYTYLRKDISIIGCGGISYGKDIFEHILCGASAVQIGTQLMKEGISVFERLKKE 296 Query: 336 I 336 Sbjct: 297 F 297 >UniRef50_A0LUF8 Dihydroorotate oxidase B, catalytic subunit n=6 Tax=Actinomycetales RepID=A0LUF8_ACIC1 Length = 351 Score = 184 bits (467), Expect = 4e-45, Method: Composition-based stats. Identities = 64/299 (21%), Positives = 114/299 (38%), Gaps = 22/299 (7%) Query: 44 AKPVNCMGLTFKNPLGLAAGLDKDG-ECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFR 102 + NP+ A+G G E + G++ ++ P+ G PR+ Sbjct: 26 DLTTQLGSVVLPNPVTTASGCAAAGRELGQFVDVSTLGAVVTKSIMLAPRAGRPTPRMAE 85 Query: 103 LVDAEGLINRMGFNNLGVDNLVEN--VKKAHYDGVLGINIGKNKDTPVEQGKDDYLICME 160 GL+N +G G+D +E+ A + ++I + Sbjct: 86 --TPSGLLNGIGLQGPGIDEFLEHDLPWLAEHGARAIVSIAGSSVGEYAALAARLRGAAP 143 Query: 161 KIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAP 220 + + +NIS PN G+ A ++ VP+ K++P Sbjct: 144 VVA-----LEVNISCPNVED-----RGQVFACDPRAASAVLAAVREAADPAVPVFAKLSP 193 Query: 221 DLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQ---GMKNCDQTGGLSGRPLQLKSTE 277 D+++ ++ VA + V DG+ NT L + TGGLSG ++ + Sbjct: 194 DVTD--IVAVATACVAAGADGLSLINTLLGLVIDTETLRPALSGVTGGLSGPAIRPVAVR 251 Query: 278 IIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + ++ L +PIIG+GGI S + A + + AGA V + + IF P I + Sbjct: 252 CVWQVHAAL-PDVPIIGMGGIRSGLDALQFLLAGACAVSVGTE-IFHDPSAPARIRDEL 308 >UniRef50_A1RZC9 Dihydroorotate oxidase B, catalytic subunit n=2 Tax=Archaea RepID=A1RZC9_THEPD Length = 299 Score = 183 bits (464), Expect = 1e-44, Method: Composition-based stats. Identities = 73/297 (24%), Positives = 127/297 (42%), Gaps = 25/297 (8%) Query: 44 AKPVNCMGLTFKNPLGLAAGLDKDGE-CIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFR 102 V GL +NP+ +A+G+ + G G++ TVT P+ G P ++ Sbjct: 3 ELSVEVAGLRLRNPVVVASGVLGVSVGLMKRAEDAGAGAVTSKTVTLNPREGYPNPVVYE 62 Query: 103 LVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKI 162 L GL+N MG N G + + +++A VLGI + + D + + + Sbjct: 63 L--DYGLVNSMGLPNPGAEEMGRILREARR--VLGIPV----IASIGASTPDEALRIAEA 114 Query: 163 YAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDL 222 + +N S P+ GL G L A+ + L++ ++ + +K++P Sbjct: 115 LEGFDALELNASCPHVKGL-----GADLMSDPDAVYGIVSALKSSGYR---VFLKLSP-- 164 Query: 223 SEEELIQVADSLVRHNIDGVIATNTTLDRSLV---QGMKNCDQTGGLSGRPLQLKSTEII 279 + + VA +DG A NT + + GGLSGR + + ++ Sbjct: 165 -HGDYLAVARKAYSAGVDGFTAINTAKAMVIDVYARKPVLGGVVGGLSGRAIHPIAVRVV 223 Query: 280 RRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 L E +P+IG GG++ + A E I AGAS V + + +G +I EI+ I Sbjct: 224 YELHREF-PEVPVIGTGGVEGWVEAVELILAGASAVGVGTAL-KRGFEVIGEILGGI 278 >UniRef50_A5IK84 Dihydroorotate dehydrogenase n=10 Tax=Thermotogaceae RepID=PYRD_THEP1 Length = 270 Score = 181 bits (461), Expect = 2e-44, Method: Composition-based stats. Identities = 72/291 (24%), Positives = 120/291 (41%), Gaps = 33/291 (11%) Query: 52 LTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLIN 111 L K PL L +G GE + + G + + TVT P+ GN PR+ +IN Sbjct: 2 LELKPPLVLLSGPAGFGEYLKLMDHRYVGGVLLKTVTLHPKEGNPTPRMA--DSDFYVIN 59 Query: 112 RMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAG---Y 168 R+G N G+ VEN+ + + ++G ++YL A Sbjct: 60 RIGLENPGIHAFVENIPE--LPVPMIASLG-------GDSFEEYLEVARVFKKVADRFYA 110 Query: 169 IAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEE 226 + N S PN GL ++ E LL ++ K +P + IA E Sbjct: 111 VEFNFSCPNVKEGGLSIVKNAEEWKKLLNTLR-----------KELPDSFLIAKVGVEGI 159 Query: 227 LIQ-VADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLE 285 ++ A+ +++ DG+ NT + K+ GGLSG L+ + + + Sbjct: 160 FVEDAAEFVMKTGWDGITLVNTVRG---LHFEKDTMILGGLSGPVLKPIALRAVYEVKKR 216 Query: 286 LNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 L +I GG+ SV A E + GA ++ + S FK P +++EI ++ Sbjct: 217 F-PELFVIASGGVYSVKDAEEFLKVGADVIGVGSAL-FKDPGVVEEIGKYL 265 >UniRef50_C0ZGG5 Hypothetical membrane protein n=1 Tax=Brevibacillus brevis NBRC 100599 RepID=C0ZGG5_BREBN Length = 631 Score = 181 bits (460), Expect = 3e-44, Method: Composition-based stats. Identities = 75/332 (22%), Positives = 133/332 (40%), Gaps = 28/332 (8%) Query: 13 LDPERAHEFTFQQLRRITGTP-----FEALVRQKVPAKPVNCMG-LTFKNPLGLAAGLDK 66 + PERA T + + + P E + + P++ MG +TF P+GL AGLD Sbjct: 1 MPPERARSITLKSIGTLAKIPGGPSIIEWMGHMEPPSQLSKTMGPVTFPTPVGLGAGLDT 60 Query: 67 DGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVEN 126 + I AL GFG +E+G V+ P + + R + A + N G+ +L+ Sbjct: 61 ECIAIQALSKFGFGFLELGPVSKEPIVSHGT--VQRDITAMNIHYSGHLVNNGIYSLLRR 118 Query: 127 VK-KAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINI-SSPNTPGLRTL 184 + A +G+ + +T + + ++ + K+ + I+ ++ P Sbjct: 119 LTGSAGIKIPIGVRLACQPETSLREATEELQELIGKLEHICSFFTIDTRANLGQPEWSHT 178 Query: 185 QYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIA 244 + E L +P+ + I P LSE E + + S ++G++ Sbjct: 179 AWKEHFSCL-------------RSQTDLPLLLAIPPSLSETEALPILTSAKEAGLNGLVV 225 Query: 245 TNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAA 304 + TG S ++ + + + L IIG GG+ A Sbjct: 226 AGGIIQEDSSCANTFVYTTGRSS----HKQAVKFVSWTREQWPDAL-IIGSGGVLEPQDA 280 Query: 305 REKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 +AAGA VQ++SG ++ GP L K I I Sbjct: 281 LTFLAAGADFVQLHSGLVYSGPGLPKRINEAI 312 >UniRef50_C0WNB5 Dihydroorotate dehydrogenase n=3 Tax=Lactobacillus RepID=C0WNB5_LACBU Length = 315 Score = 181 bits (459), Expect = 3e-44, Method: Composition-based stats. Identities = 75/310 (24%), Positives = 124/310 (40%), Gaps = 40/310 (12%) Query: 44 AKPVNCMGLTFKNPLGLAAGL-DKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFR 102 + N F N L AAG+ + + + G + TP+P+ GN+ PR+ Sbjct: 7 SLKANIGKYRFNNVLLNAAGIRCATTDELTKILRSTAGGCVTKSATPQPREGNESPRM-- 64 Query: 103 LVDAEGLINRMGFNNLGVDNLVENVKK--AHYDGVLGINIGKNKDTPVEQGKDDYLICME 160 G IN MG N G+D ++ ++ D + ++I D L + Sbjct: 65 KATPLGCINSMGLPNHGLDYYLKFAEENQRKNDNQVILSIA-------GLSVDQNLEMLH 117 Query: 161 KIYA--YAGYIAINISSPNTPGLRTLQYG-EALDDLLTAIKNKQNDLQAMHHKYVPIAVK 217 +I + G +N+S PN G + Y EA+ D+LT +A I +K Sbjct: 118 QIQDSLFDGLTELNLSCPNIKGESQIAYDFEAVRDILT---------KAFDFFTKDIGIK 168 Query: 218 IAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRP------- 270 + P + Q+AD L I V + N+ + G+ +T + +P Sbjct: 169 LPPYFDLHQFDQIADVLNEFPIAYVNSINSIGN-----GLIVNPETESVVLKPKGGFGGL 223 Query: 271 ----LQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGP 326 ++ + +R L L L + IIG GGI S E I GA++VQI + F F+ Sbjct: 224 GGDYVKPTALANVRGLRLRLKPEIAIIGTGGIKSGRDVFEHILCGANVVQIGTAFGFEDV 283 Query: 327 PLIKEIVTHI 336 + I + Sbjct: 284 KIFDRISKEL 293 >UniRef50_A3DM44 Dihydroorotate oxidase B, catalytic subunit n=1 Tax=Staphylothermus marinus F1 RepID=A3DM44_STAMF Length = 301 Score = 181 bits (459), Expect = 3e-44, Method: Composition-based stats. Identities = 75/299 (25%), Positives = 126/299 (42%), Gaps = 27/299 (9%) Query: 44 AKPVNCMGLTFKNPLGLAAG-LDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFR 102 G+ FK+P+ A+G L + L G I T+T +P+ G P Sbjct: 2 DLTTKVTGIVFKHPIMNASGILASSINGVGILAKTGVAGIVTKTLTLKPREGYLPPITIP 61 Query: 103 LVDAEGLINRMGFNNLGVDNLVENVKKAHYDG-VLGINIGKNKDTPVEQGKDDYLICMEK 161 L GL+N +G N G+D + V++ H G ++IG + ++ I EK Sbjct: 62 L--DYGLLNAVGLANPGIDAVNVLVEEIHKYGLPAIVSIG-------GRDPREFQILAEK 112 Query: 162 -IYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAP 220 + A + +N+S P+TPG +D + T K L +P+ K+ Sbjct: 113 ALDARPEALELNLSCPHTPGFG-------VDTVATDEVLKHVALNVSSVSNIPVWGKLG- 164 Query: 221 DLSEEELIQVADSLVRHNIDGVIATNTTLDRSL---VQGMKNCDQTGGLSGRPLQLKSTE 277 +I+ ++ L+ + +D V+ NT + V GGLSG + + Sbjct: 165 --FSRRIIRESEILLNNGVDAVVLINTLPGMFIDVYVGKPVLTHGFGGLSGPAIHPVAVY 222 Query: 278 IIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + ++ EL IIGVGG+ + E + AGA +QI +GF G ++ I+ I Sbjct: 223 SVYKVYEELGAE--IIGVGGVIDWKTSVELLLAGAKAIQIGTGFYMVGYNIVNNILDGI 279 >UniRef50_D0U5Z4 Dihydroorotate dehydrogenase subfamily 1 family protein n=1 Tax=uncultured actinobacterium RepID=D0U5Z4_9ACTN Length = 324 Score = 181 bits (459), Expect = 4e-44, Method: Composition-based stats. Identities = 74/313 (23%), Positives = 126/313 (40%), Gaps = 31/313 (9%) Query: 37 LVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMG-FGSIEIGTVTPRPQPGN 95 + +K V + FK+P+ LA+G + ++ + G+I + +++ GN Sbjct: 1 MRGKKHFDHSVRVDDVEFKSPVLLASGTAGHADELEPYFPLSKIGAIVVKSMSSFEWAGN 60 Query: 96 DKPRLFRLVDAEGLINRMGFNNLGVDNLVEN--VKKAHYDGVLGINIGKNKDTPVEQGKD 153 PRL G++N +G LGV + +E+ + + +I D Sbjct: 61 KAPRL--RPTNGGMLNAVGLQGLGVAHWIEHDLPRLKKVKATIVASIWGF-------SID 111 Query: 154 DYLICMEKIYAYA---GYIAINISSPNT----PGLRTLQYGEALDDLLTAIKNKQNDLQA 206 DY + + I IN+S PN T A D+ L+A ++ Sbjct: 112 DYRSAASLLSEVSTDLAAIEINLSCPNIGSSSKAANTPHGIFAHDEDLSA-----EIVRV 166 Query: 207 MHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLV---QGMKNCDQT 263 VP+ K++P+ ++ VA ++ + V NT L ++ + Sbjct: 167 CSVAKVPLWAKLSPNTDR--VVDVAAAVSKAGCQAVTLINTALGLAIDVETGLPALGNGG 224 Query: 264 GGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIF 323 GGLSG + + I + L RLPIIGVGGI + A E + AGAS +Q+ + F Sbjct: 225 GGLSGSGIHPIAVRTIFDVRTRL-PRLPIIGVGGIANGEDAIEMMMAGASCIQVGTA-TF 282 Query: 324 KGPPLIKEIVTHI 336 P I + Sbjct: 283 ADPRAAMRIDREM 295 >UniRef50_Q73P17 Dihydroorotate dehydrogenase/oxidoreductase, FAD-binding n=1 Tax=Treponema denticola RepID=Q73P17_TREDE Length = 591 Score = 180 bits (458), Expect = 5e-44, Method: Composition-based stats. Identities = 57/256 (22%), Positives = 109/256 (42%), Gaps = 20/256 (7%) Query: 74 LGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVK--KAH 131 +GFG + + P PGN +P L + N +G N G++ V+ +K ++ Sbjct: 45 ADELGFGLVTTKSFQVLPNPGNREPILCE-PELGCFGNSVGLRNCGMEQAVKELKELRSS 103 Query: 132 YDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALD 191 + +N+ + P +D++ ++ A +N S P+ G Sbjct: 104 WKTDSILNVSLSASNP-----EDFISLLKGFEELADCFELNFSCPHASAGFGASIGCDPA 158 Query: 192 DLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDR 251 +K + L VPI VK+ P++ E++ +A +++ DG+ A NT + Sbjct: 159 IAAEYVKIIKKAL---PDCAVPIFVKLTPNV--EDIGAIASAVIEAGADGITAINTVGPK 213 Query: 252 SLVQGMKNC-------DQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAA 304 ++ GG+SG + ++ E I ++ + +PIIG+GG+ + A Sbjct: 214 VYIEPHSGKPILQNKLGGKGGMSGAWVFPRALECIGQIRKAVGEEIPIIGMGGVMTGAQA 273 Query: 305 REKIAAGASLVQIYSG 320 E + AGA ++ I S Sbjct: 274 AELVRAGADIIGIGSA 289 >UniRef50_Q1AVZ1 Dihydroorotate oxidase B, catalytic subunit n=1 Tax=Rubrobacter xylanophilus DSM 9941 RepID=Q1AVZ1_RUBXD Length = 304 Score = 180 bits (458), Expect = 5e-44, Method: Composition-based stats. Identities = 67/298 (22%), Positives = 123/298 (41%), Gaps = 32/298 (10%) Query: 43 PAKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFR 102 P V G+ PL A+G +A G +G++ TVT RP+ GN PR+ Sbjct: 4 PELSVELCGVRLATPLIPASGTLAPEALGEAAGV--YGAVLPKTVTLRPRQGNPPPRVAE 61 Query: 103 LVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKI 162 G++N +G N GV+ + + + +++ + +++ + ++ Sbjct: 62 --SPAGMVNSIGLQNPGVEEFLRALGAWEVGVPVFVSVA-------GETVEEFALLCGRV 112 Query: 163 YA--YAGYIAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKI 218 A A I +N+S PN G A+++++ A + D VP+ K+ Sbjct: 113 AADGRAAAIELNLSCPNVERGGQVFCAGPSAVEEVVAACRRAAPD--------VPLLAKL 164 Query: 219 APDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEI 278 A E ++Q A + DG+ NT ++ + GGLSG ++ + Sbjct: 165 A----LEGVVQNALAAEAAGADGLTVMNTVPALAVDARARRVLLRGGLSGPAIKPLALRA 220 Query: 279 IRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + ++ +P++G GG+ S E + AGA VQ+ S + P EI+ Sbjct: 221 VYDVASAA--EIPVVGCGGVCSGADVAEFMLAGARAVQVGSAGFVRDPA---EILAEF 273 >UniRef50_C7M0V6 Dihydroorotate dehydrogenase family protein n=1 Tax=Acidimicrobium ferrooxidans DSM 10331 RepID=C7M0V6_ACIFD Length = 309 Score = 180 bits (457), Expect = 7e-44, Method: Composition-based stats. Identities = 73/290 (25%), Positives = 121/290 (41%), Gaps = 22/290 (7%) Query: 52 LTFKNPLGLAAGLDKDGECIDALGAMG-FGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLI 110 L NP+ AAG G + A A+ G+ + ++T GN PRL G++ Sbjct: 11 LVLANPILTAAGCGGYGTELAAAVALERLGAHVVKSLTTVATEGNPAPRLA--PVPGGMV 68 Query: 111 NRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIA 170 N +G G+D + + D + + + P + G + + +I YI Sbjct: 69 NSVGLAGPGIDRWLAETWPSLADARIPVALSVWGRQPRDYG--ETVRRAARIAPSLVYIE 126 Query: 171 INISSPNTPGLRTL--QYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELI 228 +N+S PN R L A ++ A++++ PI VK++ + ++ Sbjct: 127 LNLSCPNLEADRALFAHDPNATARVVGAVRDEV---------ATPILVKLSANTDR--IV 175 Query: 229 QVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQT--GGLSGRPLQLKSTEIIRRLSLEL 286 VA + V DG++A NT + G + GGLSGR +Q + + L L Sbjct: 176 DVAHAAVAAGADGLVAINTLFAQWYDDGREALGTARGGGLSGRAVQPIALRAVADLRAAL 235 Query: 287 NGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 +PIIGVGG+ + + AGA VQI + F P ++ I Sbjct: 236 -PTVPIIGVGGVATADDVERFVRAGADAVQIGTAL-FVDPRRPVLVLAEI 283 >UniRef50_Q0CXV7 Putative uncharacterized protein n=1 Tax=Aspergillus terreus NIH2624 RepID=Q0CXV7_ASPTN Length = 708 Score = 178 bits (452), Expect = 2e-43, Method: Composition-based stats. Identities = 91/358 (25%), Positives = 131/358 (36%), Gaps = 113/358 (31%) Query: 22 TFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGS 81 T + R P L+ + G T NP+G++AGLDK E D L A+G Sbjct: 92 TRASVHRYGVVPLIRLL-YPDAEDAHHIFGYTISNPIGISAGLDKHAEIPDPLFALGPAI 150 Query: 82 IEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLV----------------- 124 +E+G TP PQ GN +PR+FRL +INR G N+ G D++ Sbjct: 151 VEVGGTTPLPQEGNPRPRVFRLPSQRAMINRYGLNSKGADHMAALLDARVRAWAYAHGFG 210 Query: 125 --ENVKKAHYDGVLG-------------INIGKNKDTP---VEQGKDDYLICMEKIYAYA 166 E K A +G G + + KNK TP +E K DY+ C++++ YA Sbjct: 211 DHEAAKTAVLNGAAGVPPGSLQAGKLLAVQVAKNKATPDGDLEAIKRDYVYCVDRVAPYA 270 Query: 167 GYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEE 226 + +N+SSPNTPGLR LQ L +L A+ + + VK Sbjct: 271 DIVVVNVSSPNTPGLRDLQATAPLTAILRAVVGAAKSVDRATKPV--VMVK--------- 319 Query: 227 LIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLEL 286 TGG SG L ++ ++ R L Sbjct: 320 ------------------------------------TGGYSGPQLFDRTVALVARYRALL 343 Query: 287 NGRLP------------------------------IIGVGGIDSVIAAREKIAAGASL 314 + P + GGI + AR + AGAS+ Sbjct: 344 DQGPPSEGAGAATGAQGAEAGSAKVPSGEAAARKVLFASGGITNGQQARAVLDAGASV 401 >UniRef50_Q9YFI6 Dihydroorotate dehydrogenase n=3 Tax=Desulfurococcales RepID=PYRD_AERPE Length = 306 Score = 178 bits (452), Expect = 3e-43, Method: Composition-based stats. Identities = 59/299 (19%), Positives = 115/299 (38%), Gaps = 24/299 (8%) Query: 43 PAKPVNCMGLTFKNPLGLAAGLDK-DGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLF 101 P ++ GL + P+G A+G+ + + G G +VT +P+ G +P L+ Sbjct: 5 PELSISIAGLRLQRPVGNASGILGWEPREARLVEEGGGGFFVAKSVTYQPRKGYPQPHLY 64 Query: 102 RLVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEK 161 A G++N +G N G + + + + + + + +++ Sbjct: 65 --PVAGGIVNAVGLANPGFREASKMLAQTVEEASIPV-----IASIAGGAPGEWVEMAST 117 Query: 162 IY-AYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAP 220 + A + +N+S P+ G G L A +P+ K+ Sbjct: 118 LEEAGVSAVELNLSCPHFAG-----GGLELGQDPAA--VASVVSAVASTLRIPVIAKLGY 170 Query: 221 DLSEEELIQVADSLVRHNIDGVIATNTTLDRSLV---QGMKNCDQTGGLSGRPLQLKSTE 277 + L+ A + G+ N+ + + ++ GGLSG+P+ + Sbjct: 171 ---SDRLVDAASKALEAGARGLTLINSMRAMKIDVYAKKPVLGNRVGGLSGKPIHPIAVR 227 Query: 278 IIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + + E I GG++S A E AGA VQ+ + FI GP +++ IV + Sbjct: 228 AVYEVYGETRAD--IFAAGGVESWEDAVEFYLAGAKAVQVGAAFITIGPHVLRSIVEGV 284 >UniRef50_A6DND8 Dihydroorotate dehydrogenase n=1 Tax=Lentisphaera araneosa HTCC2155 RepID=A6DND8_9BACT Length = 358 Score = 174 bits (442), Expect = 4e-42, Method: Composition-based stats. Identities = 89/361 (24%), Positives = 141/361 (39%), Gaps = 50/361 (13%) Query: 4 PFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAAG 63 + +LF + L + P + P GL F+N LG AAG Sbjct: 17 KLLPPSLFMKVYSSGRNKFIKDLAALQLDPVKGDFN------PTELCGLKFRNDLGNAAG 70 Query: 64 LDKDGECIDALGAMGFGSIEIGTVTPRPQPGN--------DKPRLFRLVDAEGLINRMGF 115 LDKDG +D +G G +GTV +P GN P L ++ +N +G Sbjct: 71 LDKDGSLLDFNYNLGAGFAVVGTVLDKPHTGNLFNAFGKERNPW-APLPNSHSALNSLGL 129 Query: 116 NNLGVDNLVENVKK-----AHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIA 170 +LGVD V+N+K D +G++I + E L C++K A +I Sbjct: 130 PSLGVDVAVDNIKAFQDRVQPQDFPIGVSIMGHPAQEGEVKLQGVLDCVKKSLPVADFIE 189 Query: 171 INISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQV 230 IN S PN G A+ + ++A+ + D VPI +K+ S + +V Sbjct: 190 INESCPNVKG----HDSSAMYERISAVMDVATD-------QVPIFIKLG---SLDHAEEV 235 Query: 231 ADSLVRHNIDGVIATNTTLDRSL-----------VQGMKNCDQTGGLSGRPLQLKSTEII 279 + GV+ NT D V + +GGLSG ++ + + + Sbjct: 236 LAKFAEMKVAGVVLLNTQRDYDFYRPKLDKGDHKVFDFYTKEFSGGLSGTIIRQTALDAV 295 Query: 280 RRLSLELNG---RLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKE-IVTH 335 + + L +I VGGI + E A L + YS F+ + L + I H Sbjct: 296 KEAKAIIEQQKLDLKLIHVGGIGNNQDVCESRKY-AELREWYSLFMERLFELPADQIYKH 354 Query: 336 I 336 + Sbjct: 355 L 355 >UniRef50_UPI0001C31DA9 dihydroorotate dehydrogenase family protein n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C31DA9 Length = 303 Score = 173 bits (440), Expect = 6e-42, Method: Composition-based stats. Identities = 65/307 (21%), Positives = 120/307 (39%), Gaps = 30/307 (9%) Query: 40 QKVPAKPVNCMGLTFKNPLGLAAGLDKDGECIDALGA-----MGFGSIEIGTVTPRPQPG 94 P+ P + G+ +P+ +G A G F + TVT P+ G Sbjct: 1 MSAPSLPTSFCGIELAHPIVNGSGTFDAIAAQRAFGDALVEQFPFAAFVSKTVTVAPREG 60 Query: 95 NDKPRLFRLVDAEGLINRMGFNNLGVDNLVEN--VKKAHYDGVLGINIGKNKDTPVEQGK 152 N PRL+ L GLIN +G N G+ + + + A L +N+ V Q Sbjct: 61 NPPPRLWELP--AGLINSIGLPNKGLAGYLTHDLPELARLPVPLIVNVMGFTREEVAQLV 118 Query: 153 DDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYV 212 + + +N+S PN G + T ++ + K Sbjct: 119 TAFAER-----DEVAALELNVSCPNVE------TGTIMGSDPTETARLVERVRPLTQK-- 165 Query: 213 PIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMK---NCDQTGGLSGR 269 PI VK+ P+ S+ + ++ DG+ NT +L + TGG+SG Sbjct: 166 PIVVKLTPNASDPGAVA--EAAEAAGADGLSLINTIRGMALDPRTREPWLGAGTGGVSGA 223 Query: 270 PLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLI 329 ++ + + ++ ++ +P+I +GG+ A + + AGA+LV + + F+ P Sbjct: 224 TVRAVALAQVSDVAQRVS--IPLIAMGGVQRGRDADDLLRAGATLVAVGTE-SFRDPAAG 280 Query: 330 KEIVTHI 336 + + + Sbjct: 281 RRVAHEL 287 >UniRef50_B7RZ94 Dihydroorotate dehydrogenase family protein n=3 Tax=Bacteria RepID=B7RZ94_9GAMM Length = 552 Score = 172 bits (436), Expect = 2e-41, Method: Composition-based stats. Identities = 54/299 (18%), Positives = 111/299 (37%), Gaps = 30/299 (10%) Query: 32 TPFEALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDG-----ECIDALGAMGFGSIEIGT 86 P +L + G T P + +G+ D + +G + + Sbjct: 1 MPHPSLHPTESSNLSTELFGKTLSGPFTIPSGIVTTAVPIIQYIFDHMPEVGV--VTTKS 58 Query: 87 VTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDT 146 + P P+ G +P L + +N +G N G E + + + + Sbjct: 59 IGPEPRDGYREPVLSQYA-PGCFVNAVGLTNPGPQRSAELMAQLRVPEDRFL-----LTS 112 Query: 147 PVEQGKDDYLICMEKIYAYAGYIAINISSPNTPG--LRTLQYGEALDDLLTAIKNKQNDL 204 D+++ + + + + +N+S P+ G + Q + + +++ A+K + Sbjct: 113 IFGGSIDEFVEVAKILAPVSDGLELNLSCPHAKGYGMAMGQDPDMVREIVAAVKAVVD-- 170 Query: 205 QAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLD--RSLVQGMKNCDQ 262 +P+ K+ P+ + + +A + DG A NT S + Sbjct: 171 -------IPVIPKLTPNTPD--ITVIARAAEAGGADGFCAINTVGPGYTSAHGHPVLSNG 221 Query: 263 TGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGF 321 GG+SG+ + + ++ ++ LPIIG GG+ S R AGA +V + S Sbjct: 222 AGGMSGKGILPIGLKCVKEVAEV--SDLPIIGCGGVSSADDVRAFFDAGAEIVGVGSAL 278 >UniRef50_B5YA20 Dihydroorotate dehydrogenase (Dihydroorotate oxidase)(Dhodehase) (Dhodase) (Dhod) n=1 Tax=Coprothermobacter proteolyticus DSM 5265 RepID=B5YA20_COPPD Length = 274 Score = 170 bits (431), Expect = 8e-41, Method: Composition-based stats. Identities = 64/296 (21%), Positives = 118/296 (39%), Gaps = 30/296 (10%) Query: 46 PVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVD 105 V LT KNP ++G + D + FG+ T+T P+ GN PRL Sbjct: 4 AVRLKKLTLKNPFIASSGTCGYADA-DLIPLDKFGAAVTKTITLLPRQGNRPPRLVE--T 60 Query: 106 AEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKI--Y 163 GL+N +G N+G++ + + L +++G + +D+ +E++ Y Sbjct: 61 PAGLVNSIGLQNMGLEAFKQFLTDFKKPTTLIVSVG-------GESPEDFATIVEELNTY 113 Query: 164 AYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLS 223 +N+S PN GE + + N K P+ VK++P Sbjct: 114 DLIDAFELNLSCPNVK-----TGGEVVGKDYVTVSNILEASLKSTTK--PLLVKLSP--F 164 Query: 224 EEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKN---CDQTGGLSGRPLQLKSTEIIR 280 E+L ++ ++ + NT + +GGLSG + I Sbjct: 165 TEQLDKILQH-WESKVEAFVLFNTFPAMDIDPRSGKPVLGAVSGGLSGPAIYPIVLNSIY 223 Query: 281 RLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + S ++ GGI + A++ I AGA ++I +G ++ P I+ ++ + Sbjct: 224 KYSKAH----TLVASGGIATTDIAKKFIMAGARALEIGTGNLWN-PAFIEMLLKEV 274 >UniRef50_A3U0T3 Probable dihydroorotate dehydrogenase, catalytic subunit n=1 Tax=Oceanicola batsensis HTCC2597 RepID=A3U0T3_9RHOB Length = 314 Score = 169 bits (429), Expect = 1e-40, Method: Composition-based stats. Identities = 65/282 (23%), Positives = 115/282 (40%), Gaps = 27/282 (9%) Query: 44 AKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRL 103 V G+ KNP+ A+G +G D + G+I + T+TP + G PR+ Sbjct: 3 DLSVTVGGVRMKNPVMPASGSIAEG-MADVVDLGRLGAIVLKTITPDLRQGVKPPRVVEY 61 Query: 104 VDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKI- 162 D + +G + G D L+ + + + DT +D+ I Sbjct: 62 TD--ATLFSIGIPSKGPDYLLNHTVPFFDKFGPPVIASISADT-----VEDFGKLAGYIT 114 Query: 163 YAYAGYIAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAP 220 I NIS PN G A ++TA+K + +PI K+ P Sbjct: 115 DPRIAAIEANISCPNLRAHGRAFGMDPVASAQVITAMKA---------NTTLPIWAKLTP 165 Query: 221 DLSEEELIQVADSLVRHNIDGVIATNTTLDRSLV---QGMKNCDQTGGLSGRPLQLKSTE 277 ++ + + ++A + D VI N L ++ + + GGL+G ++ Sbjct: 166 NVGD--IAEMARCVEGAGADAVITANAILGMAIDAETMTPRLGNVVGGLTGPAVKPVILR 223 Query: 278 IIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYS 319 ++ + + + ++P+IG GGI + E + AGAS VQI + Sbjct: 224 MVNQCAEAV--KIPVIGCGGIATGEDVVEYMLAGASAVQIGT 263 >UniRef50_A9BIU8 Dihydroorotate dehydrogenase family protein n=10 Tax=Bacteria RepID=A9BIU8_PETMO Length = 363 Score = 168 bits (426), Expect = 3e-40, Method: Composition-based stats. Identities = 72/305 (23%), Positives = 127/305 (41%), Gaps = 43/305 (14%) Query: 42 VPAKPVNCMGLTFKNPLGLAAGLD-KDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRL 100 + V+ +G+ K P+ AAG KDGE G G+I TV+ R KP + Sbjct: 1 MADISVDLLGMLLKTPVMPAAGPPIKDGESAHKAKEGGAGAIVTKTVSARAAK-VPKPNM 59 Query: 101 FRLVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICME 160 ++ G IN ++ L ++ +E + L + IG V +D + Sbjct: 60 AQV--KGGFINTELWSELSLEQWIEKEYPQVVETGLPVIIG------VGYTSEDIKEVIP 111 Query: 161 KIYAYAGYIAIN---ISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVK 217 K+ +A ++ + + TP + +++ + DL P+ VK Sbjct: 112 KVERFADAFELSTHYLGNDPTPMINSIRAAKETTDL-------------------PVMVK 152 Query: 218 IAPDLSEEELIQVADSLVRHNIDGVIATNT---TLDRSLVQGMK---NCDQTGGLSGRPL 271 ++P + + A DG++ N+ TLD L G + + G LSG+ + Sbjct: 153 LSPQVDIPKF---AKEAENAGADGLVLINSFGPTLDIDLESGKPLLGSENGFGWLSGQAI 209 Query: 272 QLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKE 331 + + +N +P++GVGGI++ A + I AGA VQ+ + I GP + K+ Sbjct: 210 FPLALRSVFEAVRSVN--IPVVGVGGINTGKEAIKMIMAGAQAVQVCTAAILNGPQIYKK 267 Query: 332 IVTHI 336 I I Sbjct: 268 ITNEI 272 >UniRef50_D2QWH7 Dihydroorotate dehydrogenase family protein n=6 Tax=Planctomycetaceae RepID=D2QWH7_9PLAN Length = 315 Score = 166 bits (422), Expect = 8e-40, Method: Composition-based stats. Identities = 66/300 (22%), Positives = 120/300 (40%), Gaps = 28/300 (9%) Query: 44 AKPVNCMGLTFKNPLGLAAGLDKDGECIDAL-GAMGFGSIEIGTVTPRPQPGNDKPRLFR 102 V L +NP+ A+G +++L G I TVT +P+ GN R Sbjct: 12 DLSVTLGRLRLRNPILTASGTFGYAREMESLVDFSKLGGILPKTVTQQPRAGNTPWRTVE 71 Query: 103 LVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKI 162 GL+N +G +N G++ + + Y G L +I + +++ ++ Sbjct: 72 --TTAGLLNAIGLDNDGIETFIAH--HMPYLGSLPTSIIVSIAGSNHN---EFVAMAGRL 124 Query: 163 YAYAG--YIAINISSPNTP-GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIA 219 G I +NIS PN G+ + L++ PI K+ Sbjct: 125 SDIDGIAAIELNISCPNVAHGIDFGADASLCEKLVSDCVKATRH---------PILAKLT 175 Query: 220 PDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKN---CDQTGGLSGRPLQLKST 276 P+++ + VA D + NT ++ + + GGLSG ++ + Sbjct: 176 PNVTR--IADVAKGAANGGADALSLINTVQGMAIDWRKQKPLLGNVMGGLSGPAIKPIAL 233 Query: 277 EIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + ++ ++ PIIG+GGI ++ E I AGAS VQI + + P + ++ + Sbjct: 234 RCVHQVRQAVST--PIIGIGGIATIDDVMEFIVAGASAVQIGTANYYD-PTVTMKLAAAL 290 >UniRef50_O08358 Dihydroorotate dehydrogenase n=12 Tax=Sulfolobaceae RepID=PYRD_SULAC Length = 291 Score = 166 bits (420), Expect = 1e-39, Method: Composition-based stats. Identities = 68/295 (23%), Positives = 130/295 (44%), Gaps = 31/295 (10%) Query: 47 VNCMGLTFKNPLGLAAGL-DKDGECIDAL-GAMGFGSIEIGTVTPRPQPGNDKPRLFRLV 104 + G+ F++P+ +A+G+ E + + +I T+T P + P ++ Sbjct: 2 IQVAGVNFEDPIVIASGIVPPTKEYMQNVCEKYEPSAITSKTLTYSPLEPHRSPTFVKIS 61 Query: 105 DAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYA 164 D +N +G N G+ ++ ++ + L I+IG + ++Y+ + KI Sbjct: 62 DNC-YLNAIGLGNPGIQ-ILRDLGEIKCK--LIISIGGSN-------VNEYIDAVSKIND 110 Query: 165 YAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSE 224 I +N+SSPN G + LT ++ +++++ K P+ VK+ P Sbjct: 111 IPVMIELNVSSPNRRGFG--------ESNLTYVEEIVKNVKSIVKK--PVFVKLGP---W 157 Query: 225 EELIQVADSLVRHNIDGVIATNTTLDRSLV---QGMKNCDQTGGLSGRPLQLKSTEIIRR 281 + ++++A + DG+ NT + TGG+SG+ + + +I Sbjct: 158 DNIVEIAGRALSAGADGLTLINTLKGMLIDVEDFKPILSYGTGGISGKCIHALAVRVIHD 217 Query: 282 LSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + E IIGVGG+ A E I+ GA LV + + + KG +I+EI I Sbjct: 218 VFKEYEPE--IIGVGGVFDWRDAIELISVGAKLVGLGTVLVEKGFDVIREIREGI 270 >UniRef50_A8MJK5 Dihydroorotate dehydrogenase family protein n=1 Tax=Alkaliphilus oremlandii OhILAs RepID=A8MJK5_ALKOO Length = 372 Score = 165 bits (417), Expect = 2e-39, Method: Composition-based stats. Identities = 64/297 (21%), Positives = 124/297 (41%), Gaps = 24/297 (8%) Query: 44 AKPVNCMGLTFKNPLGLAAG-LDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFR 102 VN +GL+ KNP+ ++AG L G + G G++ T+ +P N +PRL + Sbjct: 2 DLSVNFLGLSLKNPIIVSAGPLTGSGSMMRKAIEAGAGAVVTKTIANEIRP-NVRPRLVK 60 Query: 103 LVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGI-NIGKNKDTPVEQGKDDYLICMEK 161 EGL N ++ ++ + A G + I NI + + + +E+ Sbjct: 61 --GREGLHNIELYSGFTLEEWENEIAYAKIHGAVVIANILGHTSSEIAYIAQ----KVEQ 114 Query: 162 IYAYAGYIAINISSPNTPGL-RTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAP 220 A + + +S P+ GL + L + A+ ++ +P+ VK++ Sbjct: 115 FG--ADAVELGVSCPHGEGLEGVISEPSKLYEFTKAVVDRIK---------IPVMVKLSS 163 Query: 221 D-LSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEII 279 + ++ +L + A+ I G+ + + +G GG SG ++ I Sbjct: 164 NTVNVVKLARAAEKAGASAISGIDTVRSIAGVDIEKGRVLLPTFGGYSGDAIRPIGLAAI 223 Query: 280 RRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 ++ + +PI G+GGI + E + GAS VQ+ + I G I ++ + Sbjct: 224 ASIAQATS--IPICGIGGITNYEHILEYMMLGASTVQVCTSIILNGYEHISTLLDGL 278 >UniRef50_B0VIM3 Dihydroorotate dehydrogenase, catalytic subunit (Dihydroorotate oxidase) (DHOdehase) (DHODase) (DHOD) n=1 Tax=Candidatus Cloacamonas acidaminovorans RepID=B0VIM3_9BACT Length = 305 Score = 161 bits (409), Expect = 2e-38, Method: Composition-based stats. Identities = 60/300 (20%), Positives = 122/300 (40%), Gaps = 30/300 (10%) Query: 45 KPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLV 104 + L +P+ +A+G E +D + G+ T+T P+ GN PRL+ Sbjct: 8 LQTSLGRLKVNSPVTVASGTFAL-ENLDFIEQDHLGAYVCKTITRYPKKGNPPPRLYE-- 64 Query: 105 DAEGLINRMGFNNLGVDNLVEN---VKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEK 161 GL+N +G N G+D + V + L ++ + Q + C+EK Sbjct: 65 TEAGLLNSIGLQNPGLDKFIAEDLPVLRETLTVPLIVSFSGSSLKEFVQMLE----CLEK 120 Query: 162 IYAYAGYIAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIA 219 +GY +N+S PN G+ + ++ L + + VK++ Sbjct: 121 QEGISGY-EVNVSCPNVENEGIAFGIDPDVVNKLCALLSPLTERE---------LIVKLS 170 Query: 220 PDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQ---GMKNCDQTGGLSGRPLQLKST 276 P++++ + +A + + NT ++ + GG SG ++ + Sbjct: 171 PNVTD--IAVIAKAAEEGGATAISLINTIWGMAIDYRNGKSRIKKGIGGYSGIGIKPLAL 228 Query: 277 EIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + R + + ++P+I +GGI + A E AGAS++ + + F P + ++ + Sbjct: 229 ALTYRAAQAV--KIPVIAMGGIYNWQDALEFFWAGASMIALGTAN-FIDPLAVDKVYEGL 285 >UniRef50_B0PGY1 Putative uncharacterized protein n=1 Tax=Anaerotruncus colihominis DSM 17241 RepID=B0PGY1_9FIRM Length = 371 Score = 156 bits (395), Expect = 1e-36, Method: Composition-based stats. Identities = 64/296 (21%), Positives = 120/296 (40%), Gaps = 22/296 (7%) Query: 44 AKPVNCMGLTFKNPLGLAAG-LDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFR 102 + V +G+T KNP+ +AAG D I G ++ T+T PRL++ Sbjct: 2 SLSVQFLGMTLKNPVIVAAGPWSCDAAAIQKSIDAGAAAVVTETITLEAST-RVCPRLYQ 60 Query: 103 LVDAEGLINRMGFNNLGVDNLVENVKKA-HYDGVLGINIGKNKDTPVEQGKDDYLICMEK 161 L N M ++ + ++ + +K+ D +L ++ E +E+ Sbjct: 61 --HGGSLFNTMLYSTIDLEQWEQEIKRIDKRDSILICSVWG----ATESETAYIAKKVER 114 Query: 162 IYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPD 221 + A I ++IS+P G R+ ++G + + + ++ + +P+ VK++ D Sbjct: 115 LG--ADAIELSISAP--IGTRSTRFGRSQEQIGGYVRAVVEAVD------LPVMVKLSYD 164 Query: 222 LSEE-ELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIR 280 S + + I + + + GM GG SG L+ + Sbjct: 165 ASANVAFVHAVEQAGAQAISAIDSLKGLAGVDIEHGMPLMPTCGGYSGANLRPVALATTA 224 Query: 281 RLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 L+ R I G+GGI+S E + GA+ VQ+ S + G I IV+ + Sbjct: 225 TLAQLT--RCEICGIGGIESYEHVLEYVMLGANAVQLASTVLLAGYERITRIVSDL 278 >UniRef50_D1B5N0 Dihydroorotate dehydrogenase family protein n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B5N0_THEAS Length = 316 Score = 155 bits (391), Expect = 3e-36, Method: Composition-based stats. Identities = 66/296 (22%), Positives = 122/296 (41%), Gaps = 26/296 (8%) Query: 47 VNCMGLTFKNPLGLAAG-LDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVD 105 V+ GL +P+ +A+G L DGE ++ G G I +T P+ GN RL Sbjct: 18 VDLNGLGLSSPVVVASGVLPMDGEVWSSME--GVGLICTKGITLEPRAGNRGERLVE--T 73 Query: 106 AEGLINRMGFNNLGVDNLVENVKK--AHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIY 163 GL+N +G N G+D +E + LG+N+ + +E + + + Sbjct: 74 PSGLLNSIGLENPGIDRFLEAILPDLLRSRRSLGLNVAFSSLGELE----ELIGRIGDRA 129 Query: 164 AYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLS 223 A + +N+S PN + +GE+ + A++ + + K+ P Sbjct: 130 ASVEVLELNLSCPNVDREGAV-WGESPERTFEAVRLAR------SLWPRSVWAKLTPQAP 182 Query: 224 EEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKN---CDQTGGLSGRPLQLKSTEIIR 280 + + A + ++ NT L + GLSG + + ++ Sbjct: 183 DVAAVARAAEEAGAHC--LVVANTWLGAEVDLEAGAPVFKRVVAGLSGPAVLPLTLRLLF 240 Query: 281 RLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 +L +++ +P++ GGI S A + + AGAS VQ+ + F+ EI+ I Sbjct: 241 QLYPKVS--VPLVACGGICSPQDALKAMMAGASAVQVGTQL-FRDLGCCGEILEGI 293 >UniRef50_A4FBL7 Dihydroorotate dehydrogenase n=1 Tax=Saccharopolyspora erythraea NRRL 2338 RepID=A4FBL7_SACEN Length = 338 Score = 154 bits (389), Expect = 5e-36, Method: Composition-based stats. Identities = 67/324 (20%), Positives = 118/324 (36%), Gaps = 60/324 (18%) Query: 36 ALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMG------------FGSIE 83 LVR + A V + +N L ++ L G L G FG++ Sbjct: 8 RLVRDEPLAPAVRLGDIHLRNRLVTSSSLLGYGVANAKLIPYGMSPISQFVPLERFGAVT 67 Query: 84 IGTVTPRPQPGNDKPR----LFRLVD------------AEGLINRMGFNNLGVDNLVENV 127 T+T P+ G+ R L L G +N G+ N+G+D + + Sbjct: 68 TRTLTVEPREGHFTTRDQWPLHELPALLKRYGQALRQVDGGWLNAFGWCNVGLDAYLRDY 127 Query: 128 KKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKI-----YAYAGYIAINISSPNTPGLR 182 I++G ++++ ++KI + N+S N Sbjct: 128 YPRTRGQNTIISVGGF-------SAEEFVTLIDKINDAVPAGDIAAVEFNVSCHNV---- 176 Query: 183 TLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGV 242 + ++ +L +A+ P+ +K++PD + + A +H + + Sbjct: 177 NFDFNAIIESVLA---------EAVPRSAHPVILKLSPDY---DYLAHARLAAKHGVSAL 224 Query: 243 IATNTTLDRSLVQGMKN---CDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGID 299 A NT L ++ GGLSGR ++ ++ L + +LPII GGI Sbjct: 225 TAINTVKGLRLDPETGQPLLKNRFGGLSGRAIKPIGLRVVAELR-DAGVKLPIIATGGIR 283 Query: 300 SVIAAREKIAAGASLVQIYSGFIF 323 + RE AGA V + S F Sbjct: 284 TFDDCREYFWAGADAVSLGSATWF 307 >UniRef50_C5CHS6 Dihydroorotate dehydrogenase family protein n=1 Tax=Kosmotoga olearia TBF 19.5.1 RepID=C5CHS6_KOSOT Length = 361 Score = 154 bits (389), Expect = 6e-36, Method: Composition-based stats. Identities = 62/303 (20%), Positives = 117/303 (38%), Gaps = 41/303 (13%) Query: 44 AKPVNCMGLTFKNPLGLAAG-LDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFR 102 GL NP+ A+G L D + + AL G G++ T++ + PR Sbjct: 2 DLTTKIAGLQLANPVMPASGPLTGDDQKMLALTDFGLGAMVTKTISTKAAE---VPRPCI 58 Query: 103 LVDAEGLINRMGFNNLGVDNLV-ENVKKAHYDG--VLGINIGKNKDTPVEQGKDDYLICM 159 + ++N + + E + K L +++G +D + + Sbjct: 59 IAGKNYIMNTELWTEYPPEKWKGEFIPKFREKSSLPLIVSLG--------YTVEDLEVLV 110 Query: 160 EKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIA 219 A ++ E + L+ +K + P+ +K Sbjct: 111 PMFDDLADAFELST-------HYVADDPELMKHLIRTVKKHTDK---------PVFLKFD 154 Query: 220 PDLSEEELIQVADSLVRHNIDGVIATNTTL------DRSLVQGMKNCDQTGGLSGRPLQL 273 P + E E+ +A ++ DG++A N+ + + G +SG ++ Sbjct: 155 PSVPEPEV--MAKAVEEAGGDGIVAINSLGPGYPLYRELKSSPLGSTHGFGWISGPVIKP 212 Query: 274 KSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIV 333 + +++R++ N LPIIGVGGI S + I AGAS VQ+ SG + G + K+I+ Sbjct: 213 IALAMVKRVASSCN--LPIIGVGGISSADDVIDFIMAGASAVQLLSGALLYGKSIYKKII 270 Query: 334 THI 336 + Sbjct: 271 ADL 273 >UniRef50_B7G610 Predicted protein n=2 Tax=Bacillariophyta RepID=B7G610_PHATR Length = 387 Score = 153 bits (386), Expect = 1e-35, Method: Composition-based stats. Identities = 66/314 (21%), Positives = 119/314 (37%), Gaps = 35/314 (11%) Query: 44 AKPVNCMGLTFKNPLGLAAGL-DKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFR 102 G+ K + A+G + + G++ + T + Q GN +PR + Sbjct: 4 ELATTVAGILLKTCVYNASGPRSGTSTALSKVAQSASGAVLAKSATVQKQSGNPQPRTWH 63 Query: 103 LVDAEGLINRMGFNNLGVDNLVENVK------KAHYDGVLGINIGKNKDTPVEQGKDDYL 156 D N G N G+D ++ A D +++ + D + Sbjct: 64 HPDYIASFNSEGLPNNGIDYYIDATTIDDAMKDADDDKPYFVSLS-------GKSLHDNM 116 Query: 157 ICMEKIYA-----YAGYIAINISSPNTPGLRTLQYG-EALDDLLTAIKNKQNDLQAMHHK 210 + KI + I +N++ PN G + Y + +D +L + + L Sbjct: 117 EMLHKIASAPTKNRISAIELNLACPNVIGKPIIAYDVDQMDSILEQVSQLTDSL------ 170 Query: 211 YVPIAVKIAPDLSEEELIQVADSLVRHN--IDGVIATNTTLD------RSLVQGMKNCDQ 262 P+ VK+ P L + Q A L RH + V + NT + S + + Sbjct: 171 -PPLGVKLPPYLDFQHFQQAASVLNRHKKLVKYVASINTLGNALAVDVVSEAPCISSNSG 229 Query: 263 TGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFI 322 GLSG + + +R+L L+ + ++GVGG+ S + AGA+ VQ+ + Sbjct: 230 FAGLSGPAVHYTALANVRKLRELLDEDIDVVGVGGVRSGKDVFAMLLAGATAVQVGTCHW 289 Query: 323 FKGPPLIKEIVTHI 336 +GP IV + Sbjct: 290 IEGPSCFDRIVDEL 303 >UniRef50_A0Z3E6 Dihydroorotate dehydrogenase/oxidoreductase, FAD-binding protein n=5 Tax=unclassified Gammaproteobacteria RepID=A0Z3E6_9GAMM Length = 551 Score = 153 bits (386), Expect = 1e-35, Method: Composition-based stats. Identities = 53/285 (18%), Positives = 111/285 (38%), Gaps = 30/285 (10%) Query: 46 PVNCMGLTFKNPLGLAAGLDKDGECI---DALGAMGFGSIEIGTVTPRPQPGNDKPRLFR 102 P + +G T + +G+ I G I ++ P+ G +P ++ Sbjct: 2 PFSFLGKTLSGGFTVPSGIVTTAPSIIQRVIRDMPEIGVITTKSIGLEPRLGYREP-VYS 60 Query: 103 LVDAEGLINRMGFNNLGVDNLVENVK--KAHYDGVLGINIGKNKDTPVEQGKDDYLICME 160 +N +G N G + ++ + D L ++I ++++ + Sbjct: 61 QFAPGCFVNAVGLTNPGAHASLASLGQLRVPEDRFLLVSI-------FGGSVEEFVAVAK 113 Query: 161 KIYAYAGYIAINISSPNTPG--LRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKI 218 + A +N+S P+ G + Q + + +++ A+K + P+ K+ Sbjct: 114 ILEPVADGFELNLSCPHASGYGMAMGQDPKIVHEIIAAVKQVVSK---------PVIPKL 164 Query: 219 APDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKN--CDQTGGLSGRPLQLKST 276 P+++ + ++ + + DG+ A NT + + GG+SG+ + + Sbjct: 165 TPNVT--NIAEIGQAALDAGADGLCAINTVGPGYTESHGEAVLSNGVGGMSGKGVLPTAL 222 Query: 277 EIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGF 321 + IR L + PIIG GG+ S AGA++V I S Sbjct: 223 KCIRELRAITDK--PIIGCGGLSSAADVNAAKHAGATIVGIGSAL 265 >UniRef50_A5AEM5 Putative uncharacterized protein n=1 Tax=Vitis vinifera RepID=A5AEM5_VITVI Length = 310 Score = 150 bits (378), Expect = 9e-35, Method: Composition-based stats. Identities = 61/230 (26%), Positives = 86/230 (37%), Gaps = 68/230 (29%) Query: 4 PFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAAG 63 V LD E AH R + R + G F NP+GLAAG Sbjct: 86 KLVNPFFALLDAEVAHRLAVSAAARGLVPREK---RPDPSILGLEVWGRKFSNPVGLAAG 142 Query: 64 LDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAE---------------- 107 DK+ E ++ L +GFG +E+G+VTP PQ GN KPR+FRL Sbjct: 143 FDKNAEAVEGLLGLGFGFVEVGSVTPVPQEGNPKPRIFRLRHEGDIVEGAPTYQVSVYDC 202 Query: 108 ----------------------GLINRMGFNNLGVDNLVENVKKAH-------------- 131 +INR GFN+ G+ + + + H Sbjct: 203 FLPLKVSFSDLWAVKLLVFVVSAIINRCGFNSEGIFAVAKRLGIQHGKRKLAETSSTSSS 262 Query: 132 -----------YDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIA 170 G+LG+N+GKNK + E DY+ + + YA Y+ Sbjct: 263 SKDEVKHGGKAGPGILGVNLGKNKTS--EDAAADYVQGVHSLSQYADYLV 310 >UniRef50_C6Q0J2 Dihydroorotate dehydrogenase family protein n=1 Tax=Clostridium carboxidivorans P7 RepID=C6Q0J2_9CLOT Length = 360 Score = 149 bits (377), Expect = 1e-34, Method: Composition-based stats. Identities = 63/305 (20%), Positives = 116/305 (38%), Gaps = 48/305 (15%) Query: 45 KPVNCMGLTFKNPLGLAAGL-DKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRL 103 V+ G+ KNP+ A+G ++ +C+ G G++ T++ + R R Sbjct: 4 LNVDLHGIKIKNPIMPASGPQVRNADCMLECVKQGVGALVTKTISEK------FVRTARP 57 Query: 104 ----VDAEGLINRMGFNNLGVDNLVEN--VKKAHYDGVLGINIGKNKDTPVEQGKDDYLI 157 +N ++ L V+ VE K Y +++G + Sbjct: 58 CMQETKDGAFLNSELWSELSVEQWVEKGYSKCKSYGVPFIVSLG--------YTAKEIEK 109 Query: 158 CMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVK 217 + I YA I I + Y E +++ + L+ P+ +K Sbjct: 110 VLPIITPYADIIEI-----------STHYME------KDLESVVDSLKIASKSDKPVYIK 152 Query: 218 IAPDLSEEELIQVADSLVRHNIDGVIATNTTLD---RSLVQGMK---NCDQTGGLSGRPL 271 I+P ++ ++ LV G +A N+ + G+ G LSG+ L Sbjct: 153 ISPGIT--KIGWYVKRLVEEGAAGFVAINSLGPCLHIDVETGLPYLGGEKGYGWLSGKSL 210 Query: 272 QLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKE 331 + + ++ + ++P+IGVGGI S A I AGAS VQI + I +G + Sbjct: 211 NPIALRYVYSIANSV--KVPVIGVGGISSGEDAVAMIMAGASAVQICTAAILEGNGVYSR 268 Query: 332 IVTHI 336 + + Sbjct: 269 VSNEL 273 >UniRef50_A5VL42 Dihydroorotate oxidase B, catalytic subunit n=14 Tax=Bacteria RepID=A5VL42_LACRD Length = 432 Score = 146 bits (369), Expect = 1e-33, Method: Composition-based stats. Identities = 64/320 (20%), Positives = 128/320 (40%), Gaps = 49/320 (15%) Query: 44 AKPVNCMGLTFKNPLGLAAGLDKDG-ECIDALGAMGFGSIEIGTVTPRPQPGNDK----- 97 V+ +G+ F+NP L++ + E G+G I T++P + K Sbjct: 5 DLSVDFLGVHFENPFCLSSSPVGNCYEMCKNAYDAGWGGIVYKTLSPT----HFKIDEVS 60 Query: 98 PRLFRLVDAE----GLINRMGFNNLGVDNLV---ENVKKAHYDGVLGINIGKNKDTPVEQ 150 PR L + N + ++ + +K+ + + VL +I + + Sbjct: 61 PRFDELAKEDMHFVAFKNMEQLSEHPLEQDLADMRRLKEEYPNKVLIASI-------MGE 113 Query: 151 GKDDYLICMEKIYAY-AGYIAINISSP----NTPGLRTLQYGEALDDLLTAIKNKQNDLQ 205 +D+ + + A I +N S P +T G E A+K Sbjct: 114 TLEDWTNLAKLVTETGADMIELNFSCPQMTSHTMGSDVGTNPELCKKNCEAVKR------ 167 Query: 206 AMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTT---LDRSLVQGMKNCDQ 262 +P+ K+ P+++ ++ V + + DG A NT +D L + + + Sbjct: 168 ---GTSLPVLAKMTPNITT--MVPVVKACLEGGADGFSAINTVKSIVDVDLKKKVGLPNI 222 Query: 263 TG-----GLSGRPLQLKSTEIIRRLSLELN-GRLPIIGVGGIDSVIAAREKIAAGASLVQ 316 G GLSG+ ++ + +++L +LPI G+GGI++ A E I GA+ +Q Sbjct: 223 DGKSSVSGLSGKAVKPIALRFLQQLRSAAGLEQLPISGIGGIETWEDAAEFILLGATTLQ 282 Query: 317 IYSGFIFKGPPLIKEIVTHI 336 + + + G +I ++ + Sbjct: 283 VTTAIMEYGYRIIDDLTNGL 302 >UniRef50_Q12882 Dihydropyrimidine dehydrogenase [NADP+] n=94 Tax=Eukaryota RepID=DPYD_HUMAN Length = 1025 Score = 145 bits (367), Expect = 2e-33, Method: Composition-based stats. Identities = 64/321 (19%), Positives = 122/321 (38%), Gaps = 40/321 (12%) Query: 41 KVPAKPVNCMGLTFKNPLGLAAGLDKDG-ECIDALGAMGFGSIEIGTVTPRP-QPGNDKP 98 + V GL F NP GLA+ I G+G T + N P Sbjct: 529 DLVDISVEMAGLKFINPFGLASATPATSTSMIRRAFEAGWGFALTKTFSLDKDIVTNVSP 588 Query: 99 RLFRL--------VDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQ 150 R+ R +N + ++V + D I I + Sbjct: 589 RIIRGTTSGPMYGPGQSSFLNIELISEKTAAYWCQSVTELKADFPDNIVIASIMCSYN-- 646 Query: 151 GKDDYLICMEKIYAY-AGYIAINISSPNTPGLRTL-----QYGEALDDLLTAIKNKQNDL 204 K+D+ +K A + +N+S P+ G R + Q E + ++ ++ Sbjct: 647 -KNDWTELAKKSEDSGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAV--- 702 Query: 205 QAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQ--------- 255 +P K+ P++++ ++ +A + +GV ATNT ++ Sbjct: 703 ------QIPFFAKLTPNVTD--IVSIARAAKEGGANGVTATNTVSGLMGLKSDGTPWPAV 754 Query: 256 GMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLV 315 G+ GG+SG ++ + + ++ L G PI+ GGIDS + + + +GAS++ Sbjct: 755 GIAKRTTYGGVSGTAIRPIALRAVTSIARALPG-FPILATGGIDSAESGLQFLHSGASVL 813 Query: 316 QIYSGFIFKGPPLIKEIVTHI 336 Q+ S + +I++ T + Sbjct: 814 QVCSAIQNQDFTVIEDYCTGL 834 >UniRef50_C6QGW0 Dihydroorotate dehydrogenase n=1 Tax=Hyphomicrobium denitrificans ATCC 51888 RepID=C6QGW0_9RHIZ Length = 226 Score = 144 bits (363), Expect = 5e-33, Method: Composition-based stats. Identities = 63/287 (21%), Positives = 113/287 (39%), Gaps = 61/287 (21%) Query: 50 MGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGL 109 MGL F NP+GLAAG D+ GE + A GFG +EIGT+ Sbjct: 1 MGLHFPNPIGLAAGFDRTGEHAPSPLASGFGHVEIGTINSEA------------------ 42 Query: 110 INRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYI 169 G ++ + LGINIG + + +D+ + + + +A Y+ Sbjct: 43 ----GLATP--------LRHSANGARLGINIGSLRPGLDDLVIEDFEMRLRQAAPFADYV 90 Query: 170 AINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQ 229 N+++P ++ +D L+ + ++++ P+ VK+ + + Sbjct: 91 VANLTAP---AMQRSGNSPGVDQLMRRLSKVRDEISEARGSRTPLLVKLDGGAIGDPIPA 147 Query: 230 VADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGR 289 + + +DG++ + L R I +S + Sbjct: 148 AVTAACVYGLDGIVLVSDRLRR---------------------------IEEISNHM-AA 179 Query: 290 LPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 L +I VGGI + R ++ AGASLVQI+ F G L+ ++ + Sbjct: 180 LTLISVGGIQTAADIRARLVAGASLVQIHRAFADGGKQLLFRMLAEL 226 >UniRef50_P25889 Uncharacterized protein yeiA n=116 Tax=Bacteria RepID=YEIA_ECOLI Length = 411 Score = 144 bits (363), Expect = 6e-33, Method: Composition-based stats. Identities = 66/318 (20%), Positives = 128/318 (40%), Gaps = 47/318 (14%) Query: 44 AKPVNCMGLTFKNPLGLAAGLDKDGECIDA-LGAMGFGSIEIGTVTPR-PQPGNDKPRLF 101 + G+ F NP L++ + + A G+G + T+ PR Sbjct: 5 DLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFFIANE--VSPRFD 62 Query: 102 RLV-DAEGLINRMGFNN------LGVD---NLVENVKKAHYDGVLGINIGKNKDTPVEQG 151 LV + G I GF N ++ + +K+ + D VL +I EQ Sbjct: 63 HLVKEDTGFI---GFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMG----ENEQQ 115 Query: 152 KDDYLICMEKIYAYAGYIAINISSP----NTPGLRTLQYGEALDDLLTAIKNKQNDLQAM 207 ++ +++ A I N S P + G Q E ++ A+K Sbjct: 116 WEELARLVQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKR-------- 165 Query: 208 HHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQ-----GMKNCDQ 262 +P+ K+ P++ + + +VA + R DG+ A NT + + GM + Sbjct: 166 -GSTLPMLAKMTPNIGD--MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNG 222 Query: 263 TG---GLSGRPLQLKSTEIIRRLSLELNGR-LPIIGVGGIDSVIAAREKIAAGASLVQIY 318 G SG+ ++ + I+++ R PI G+GGI++ A E + GA+ +Q+ Sbjct: 223 KSSISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVT 282 Query: 319 SGFIFKGPPLIKEIVTHI 336 +G + G +++++ + + Sbjct: 283 TGIMQYGYRIVEDMASGL 300 >UniRef50_Q9LVI9 Senescencs-related protein; dihydroorotate dehydrogenase-like protein n=14 Tax=cellular organisms RepID=Q9LVI9_ARATH Length = 426 Score = 143 bits (362), Expect = 7e-33, Method: Composition-based stats. Identities = 56/323 (17%), Positives = 126/323 (39%), Gaps = 37/323 (11%) Query: 40 QKVPAKPVNCMGLTFKNPLGLAAGLDK-DGECIDALGAMGFGSIEIGTVTPRPQPG-NDK 97 + P V GL NP + +G + + G+G++ TV+ N Sbjct: 47 ESEPDLSVTVNGLKMPNPFVIGSGPPGTNYTVMKRAFDEGWGAVIAKTVSLDASKVINVT 106 Query: 98 PRLFRLVDAE---------GLINRMGFNNLGVDNLV---ENVKKAHYDGVLGINIGKNKD 145 PR RL G N ++ ++ ++ E +KK + D +L ++ + Sbjct: 107 PRYARLRTGSNGSAKTDVIGWQNIELISDRPLETMLKEFERLKKEYPDRILIASV---ME 163 Query: 146 TPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQ 205 + ++ + +E+ + IN S P+ G+ + G A+ + + Sbjct: 164 EYNKTAWEELIDRVEQTG--VDALEINFSCPH--GMPERRMGAAVGQDCALLDEVCGWIN 219 Query: 206 AMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQT-- 263 A VP+ K+ P++++ + + A ++ +G+ A NT + + + Sbjct: 220 AKA--TVPVWAKMTPNITD--ITEPARVSLKSGCEGIAAINTIMSVMGIDMKTLRPEPCV 275 Query: 264 ------GGLSGRPLQLKSTEIIRRLSLELNGRLP----IIGVGGIDSVIAAREKIAAGAS 313 GG S + ++ + + ++ + + G+GG+++ A E I G++ Sbjct: 276 EGYSTPGGYSYKAVRPIALAKVMNIAKMMKSEFSEDRSLSGIGGVETGYDAAEFILLGSN 335 Query: 314 LVQIYSGFIFKGPPLIKEIVTHI 336 VQ+ +G + G +K + + Sbjct: 336 TVQVCTGVMMHGYGHVKTLCAEL 358 >UniRef50_C1EGR6 Predicted protein n=8 Tax=Viridiplantae RepID=C1EGR6_9CHLO Length = 434 Score = 143 bits (362), Expect = 8e-33, Method: Composition-based stats. Identities = 64/340 (18%), Positives = 133/340 (39%), Gaps = 36/340 (10%) Query: 20 EFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAAGLDK-DGECIDALGAMG 78 + L + V P V GL F NP + +G + + G Sbjct: 39 RVVARGLEGRPWVELKDGVPTSGPDLSVTVNGLKFPNPFVIGSGPPGTNYTVMKKAFDEG 98 Query: 79 FGSIEIGTVTPRPQ-PGNDKPRLFRLVDAEGLINRMGFNNL------GVDNLVEN---VK 128 +G + TV+ N PR ++ +G +G+ N+ + ++ +K Sbjct: 99 WGGVIAKTVSLNADLVKNVTPRYAKMKSEDGAEV-LGWQNIELISDRSFEVMLAEFKQLK 157 Query: 129 KAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAY-AGYIAINISSPNTPGLRTLQYG 187 + + D +L +I E K++++ + + IN S P+ G+ + G Sbjct: 158 EEYPDRILIASIM------DEYKKENWVEVVRRCEEVGVDAFEINFSCPH--GMPERKMG 209 Query: 188 EALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNT 247 A+ T + ++ + VP+ K+ P++++ + + A+ + +DG+ A NT Sbjct: 210 AAMGQDCTVLDEVCGWVKEVA--TVPVWAKMTPNITD--ITEPANVCLEKGMDGIAAINT 265 Query: 248 TLDRSLVQGMKNCDQT--------GGLSGRPLQLKSTE---IIRRLSLELNGRLPIIGVG 296 + V + GG S + ++ + I ++ + + G+G Sbjct: 266 IMSIMGVNLDTLAPEPCVEGHSTPGGYSYKAVRPIALAKCMAIAQMIKKEFPDRTLSGIG 325 Query: 297 GIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 GID+ A E I G+ VQ+ +G + G PL++ + + Sbjct: 326 GIDTGGHAAEFILLGSDTVQVCTGVMIHGYPLVQNLCAEL 365 >UniRef50_A6LJ97 Dihydroorotate dehydrogenase family protein n=2 Tax=Thermosipho RepID=A6LJ97_THEM4 Length = 360 Score = 142 bits (359), Expect = 1e-32, Method: Composition-based stats. Identities = 58/303 (19%), Positives = 122/303 (40%), Gaps = 40/303 (13%) Query: 44 AKPVNCMGLTFKNPLGLAAG-LDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFR 102 G+ +NPL A+G L D E I + + G G+I T++ + N PR Sbjct: 2 DLSTEISGIKIENPLMPASGPLVGDYEKIKFIDSTGVGAIVTKTISTKAA--NV-PRPCI 58 Query: 103 LVDAEGLINRMGFNNLGVDNLVENVK---KAHYDGVLGINIGKNKDTPVEQGKDDYLICM 159 + ++N ++ L + ++ + K L +++G +D I + Sbjct: 59 YGENNFVMNAELWSELPPETWIKEILPKLKNELKKPLIVSVG--------YTIEDMEILI 110 Query: 160 EKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIA 219 ++ YA I+ + + +++ AI+ N PI +K++ Sbjct: 111 PQLNEYADAFEIST-------HYVGKDYNTIANIVKAIRKNTNK---------PIFMKLS 154 Query: 220 PDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTG------GLSGRPLQL 273 P + + ++ +++ + +G++A N+ + G LSG ++ Sbjct: 155 PHIPDP--VEFTKTILENGANGIVAINSWGPTMKIDIKNRKTLIGNEKGQVWLSGPVIKP 212 Query: 274 KSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIV 333 + I++ + + IIGVGGI S E + +GA VQ+ S + G + ++I+ Sbjct: 213 IALSIVKTIRDAF-PDITIIGVGGIKSAEDVIEFLLSGADAVQLLSSALIFGKDIYEKIL 271 Query: 334 THI 336 + Sbjct: 272 NQL 274 >UniRef50_UPI000187EFAF hypothetical protein MPER_16226 n=1 Tax=Moniliophthora perniciosa FA553 RepID=UPI000187EFAF Length = 181 Score = 141 bits (355), Expect = 4e-32, Method: Composition-based stats. Identities = 50/130 (38%), Positives = 74/130 (56%), Gaps = 1/130 (0%) Query: 208 HHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRS-LVQGMKNCDQTGGL 266 H I +KIAPDL + ++ +AD + + +IDGVI +NTT R + +N QTGGL Sbjct: 4 RHPKPRIVLKIAPDLDDTQIEDMADVIRKSSIDGVIVSNTTTQRPKGLVSPENKGQTGGL 63 Query: 267 SGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGP 326 SG PL+ + +R L L +PIIG GGI S A + AGA++VQ+Y+ F + G Sbjct: 64 SGPPLKSLTLNTLRILRSHLPADIPIIGCGGISSGTDALDYARAGATMVQVYTSFGYDGA 123 Query: 327 PLIKEIVTHI 336 + + + I Sbjct: 124 GMCRRVKDEI 133 >UniRef50_B8D2W4 Dihydroorotate dehydrogenase family protein n=1 Tax=Desulfurococcus kamchatkensis 1221n RepID=B8D2W4_DESK1 Length = 407 Score = 140 bits (353), Expect = 7e-32, Method: Composition-based stats. Identities = 62/315 (19%), Positives = 118/315 (37%), Gaps = 27/315 (8%) Query: 42 VPAKPVNCMGLTFKNPLGLAA-GLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRL 100 + V GL +NP+ AA + +D + + L G G++ T++ +P +P + Sbjct: 5 MADLSVELAGLKLRNPIMNAACPVSRDADAMRMLIDNGVGAVVAKTISVKP-AIVPRPSM 63 Query: 101 FRLVDAEGLINRMGFNN--LGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKD-DYLI 157 GL+ G + H +N D P E + +Y + Sbjct: 64 A--AVDRGLVRAHLLKTLKPGDVRITPVDSGNHRFIYAVLNAELWSDIPAEHYLEREYPL 121 Query: 158 CMEKIYAYAGYI---------AINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMH 208 +++ P + + + +A+ Sbjct: 122 VKSYCEEKGAVFIASIGYTPEELSLLGPKVEKAGVQAIEFSTHYIGRDYRPVIEAAKALR 181 Query: 209 HK-YVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLD---RSLVQGMKNCDQT- 263 +PI K++P + ++ L + +DG++ATNT + G+ Sbjct: 182 ESVDIPIFPKLSP--FTPNIPELVKELEKVGVDGIVATNTIGPALHIDVETGLPIVGGPY 239 Query: 264 --GGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGF 321 G +SG L+ + ++ +++ LN +LP+IGVGGI + E AGAS VQI + Sbjct: 240 GYGWMSGPALKPLALAVVSQVA--LNTKLPVIGVGGISRGVDVIEYFMAGASAVQICTAA 297 Query: 322 IFKGPPLIKEIVTHI 336 + +GP I+ + Sbjct: 298 LIEGPQAFARIIREV 312 >UniRef50_B3P4V6 GG16516 n=3 Tax=cellular organisms RepID=B3P4V6_DROER Length = 139 Score = 139 bits (351), Expect = 1e-31, Method: Composition-based stats. Identities = 44/102 (43%), Positives = 70/102 (68%) Query: 235 VRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIG 294 + ++DG+I +NTT+ R + K ++TGGLSG PL+ +STE+I ++ +G++PIIG Sbjct: 11 KKSSVDGLIVSNTTVSRENIGNNKLAEETGGLSGPPLKARSTEMIAQMYQLTDGKIPIIG 70 Query: 295 VGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 VGG+ S A EKI AGAS +QIY+ +++GP L+ +I + Sbjct: 71 VGGVASGYDAYEKIEAGASYIQIYTSLVYEGPALVDDIKAEL 112 >UniRef50_C4IB41 Dihydroorotate dehydrogenase family protein n=4 Tax=Clostridiales RepID=C4IB41_CLOBU Length = 362 Score = 134 bits (337), Expect = 5e-30, Method: Composition-based stats. Identities = 64/306 (20%), Positives = 122/306 (39%), Gaps = 47/306 (15%) Query: 45 KPVNCMGLTFKNPLGLAAG-LDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRL 103 + +NPL A+G L D + + AL G G++ T++ + + R Sbjct: 3 LNTTIGKIKLENPLMPASGPLVGDKDKMSALNEFGVGAMVTKTISSKKAE------VVRP 56 Query: 104 VDAEG---LINRMGF----NNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYL 156 G ++N + + +D + ++KK D L I++G K +D Sbjct: 57 CIYGGKNFIMNAELWSEYAPEVWIDEFLPSIKKELKDKPLIISVGYTK--------EDME 108 Query: 157 ICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAV 216 + K+ +A I + Y + L+ IK ++ K P+ + Sbjct: 109 FLIPKLDVFADAFEI-----------STHY---VGKDLSNIKETLKTIRRFTQK--PVFM 152 Query: 217 KIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTG------GLSGRP 270 K++P + + I A ++ + G++A N+ + K G SG Sbjct: 153 KMSPHIPDP--IGFAKMVIENKGSGIVAINSLGPTMNIDIDKRSVLIGNKEGEVWTSGPA 210 Query: 271 LQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIK 330 ++ + +I ++ + IIGVGGI S E + AGAS VQ+ S + KG L + Sbjct: 211 IKPMALALIHKIKKAV-PECEIIGVGGISSADDIIEFLLAGASAVQMLSAAMLKGKDLYE 269 Query: 331 EIVTHI 336 +++ + Sbjct: 270 KLIEEL 275 >UniRef50_A9GKC4 Dihydropyrimidine dehydrogenase n=5 Tax=Bacteria RepID=A9GKC4_SORC5 Length = 462 Score = 132 bits (333), Expect = 1e-29, Method: Composition-based stats. Identities = 61/319 (19%), Positives = 127/319 (39%), Gaps = 45/319 (14%) Query: 42 VPAKPVNCMGLTFKNPLGLAAGLDKD-GECIDALGAMGFGSIEIGTVTPRPQPGNDKPRL 100 + ++ G+ NP LA+ + G+ + G+G T+ GN + Sbjct: 1 MADLSIDFAGIKSPNPFWLASAPPTNTGDQVRRAFDAGWGGAVWKTL------GNPIVNV 54 Query: 101 FRLVDAEGLINR--MGFNNLGVDNLVEN-----------VKKAHYDGVLGINIGKNKDTP 147 N MG NN V+ + + +K+ + L ++ Sbjct: 55 SSRFGGIDYGNTRLMGLNN--VELITDRPLDVNLKEMREIKRRYPGHALIASL------- 105 Query: 148 VEQGKDDYLICMEKIYAY-AGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQA 206 + + KD++ + K A + +N P+ G+ G A+ + ++ A Sbjct: 106 MVETKDEWREIIRKAEDTGADGLELNFGCPH--GMCERGMGSAVGNEPAVLQEIAR--WA 161 Query: 207 MHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTL--------DRSLVQGMK 258 + P+ VK+ P++ + +++ ++++R GV NT + + Sbjct: 162 VEFATTPVIVKLTPNVGD--ILEPGEAVLRSGAHGVSLINTVKSLMGVDLERMVPLPRVG 219 Query: 259 NCDQTGGLSGRPLQLKSTEIIRRLSLELN-GRLPIIGVGGIDSVIAAREKIAAGASLVQI 317 GG G ++ + ++ +L+ GRLPI G+GGI + A E IA GA+ VQ+ Sbjct: 220 GASTNGGYCGPAVKPIALHLLSQLARHPGVGRLPISGIGGISNSRDAAEFIALGATSVQV 279 Query: 318 YSGFIFKGPPLIKEIVTHI 336 + + G +++E++ + Sbjct: 280 CTAVMHYGYRIVEEMIEGL 298 >UniRef50_C9XJU2 Dihydroorotate dehydrogenase, catalytic subunit n=5 Tax=Clostridium difficile RepID=C9XJU2_CLODC Length = 361 Score = 132 bits (333), Expect = 2e-29, Method: Composition-based stats. Identities = 67/297 (22%), Positives = 121/297 (40%), Gaps = 41/297 (13%) Query: 48 NCMGLTFKNPLGLAAGLDKD-GECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDA 106 N +G K+PL + +G L G G++ T+ + + N P + R A Sbjct: 3 NFLGKELKSPLIIGSGPLTYSAAGCKILSDAGAGAVVTKTI-RKERAINPAPHMVR-NTA 60 Query: 107 EGLINRMGFNNLGVDNLVE-NVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIY-A 164 L+N + + + ++ + + DG + I V ++ +EK+ A Sbjct: 61 NALLNNEKWTDFEPEQWIDFEIPQMKRDGTVCI-------ASVGHTIEESSELVEKVANA 113 Query: 165 YAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSE 224 A +I + +S DL+ +K+ + + +P+ VK+ P + E Sbjct: 114 GADFIEL-VS-------------YDYRDLIPMLKDAKERVN------IPVIVKLPPMIDE 153 Query: 225 EELIQVADSLVRHNIDGVIATNTT-----LDRSLVQGMKNCDQTGGLSGRPLQLKSTEII 279 + A L D + A ++ +D Q + + G LSG ++ + + I Sbjct: 154 --IGDFAKKLEEAGADAITACDSVGPAFRIDIETGQPLLGGNGIGYLSGETIKPITLQRI 211 Query: 280 RRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + ++N +PIIG+GG S A E I AGA V I S I KG +I +I + Sbjct: 212 YEIKKQVN--IPIIGLGGCVSGDDALEMIMAGADFVGICSVVILKGAQVISKIHDDL 266 >UniRef50_A4WLH6 Dihydroorotate dehydrogenase n=5 Tax=Thermoproteaceae RepID=A4WLH6_PYRAR Length = 297 Score = 129 bits (326), Expect = 1e-28, Method: Composition-based stats. Identities = 67/327 (20%), Positives = 121/327 (37%), Gaps = 48/327 (14%) Query: 6 VRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAAGLD 65 V +AL + PE +++ R + P + G+ P+G+AAGLD Sbjct: 7 VARALHYVHPEISYKLG----RLLFSLPLPPCKCEGGW----EVGGVKICGPVGIAAGLD 58 Query: 66 KDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVE 125 K G L G I +G+ PRP+ GN PR+ R+ ++N MG N+ G+ +V Sbjct: 59 KTGMYARFLSFFCPGFIVVGSTLPRPRRGNKPPRVARV-WPYSMVNAMGLNSPGLPRVVS 117 Query: 126 NVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAY--AGYIAINISSPNTPGLRT 183 + Y + I D+ + + + Y + +NISSP G Sbjct: 118 RISNLKYPVFVSI---------AGFSAGDFAVQLAYLRRYYKPAAVELNISSPTYRGFW- 167 Query: 184 LQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVI 243 + +PI +K+ P + +L + V+ G++ Sbjct: 168 ------------------RVAPELDGVDIPIFLKVGPSV---DLREAVRQAVKAGW-GLV 205 Query: 244 ATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIA 303 TNT +G L +++ R +PII GG+ + Sbjct: 206 VTNTLPIEDGRLSTGRGGLSG----LLLYRYGVKLLERARRLAGDGVPIIYSGGLYTCSQ 261 Query: 304 AREKIAAGASLVQIYSGFIFKGPPLIK 330 E + A+ ++ + ++ P ++K Sbjct: 262 LGEVLKL-ANAAEVLTSVLYYTPYILK 287 >UniRef50_A0CDX9 Chromosome undetermined scaffold_17, whole genome shotgun sequence n=1 Tax=Paramecium tetraurelia RepID=A0CDX9_PARTE Length = 997 Score = 128 bits (321), Expect = 4e-28, Method: Composition-based stats. Identities = 61/295 (20%), Positives = 98/295 (33%), Gaps = 28/295 (9%) Query: 44 AKPVNCMGLTFKNPLGLAAGLDKDGE-CIDALGAMGFGSIEIGTVTPRPQP-GNDKPRLF 101 +N +G+ F NP GLA+ I G+G + T N PR++ Sbjct: 544 DLSINILGVNFLNPFGLASAPPTTSYPMIKRAFQEGWGFAVVKTFVLDKDAITNVSPRIY 603 Query: 102 R-----LVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYL 156 + L G N + +E K + + IG +EQ D+ Sbjct: 604 KSTTDPLKQDPGYANIELISEKSAKYWLEGSKAIKKEFPNHVLIGSIMCQHIEQ---DWR 660 Query: 157 ICMEKIYAYA--GYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPI 214 K + +N+S P+ G+ L G A + +K+ +P+ Sbjct: 661 ELTRKCKNEGQFDMLELNLSCPH--GMTELGMGRACGENPAIVKDICQ--WVTSEIDIPV 716 Query: 215 AVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTL----DRSLVQGMKNCDQ-----TGG 265 VKI P+ + +A + V TNT L + GG Sbjct: 717 IVKITPNYPDS--ADIAQAAKEGGAKAVTLTNTFPTLMDPDPLGTPWPAVGEENNVTYGG 774 Query: 266 LSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSG 320 G L+ + ++ + + I G GGI A + GAS QI S Sbjct: 775 GCGSMLRPIALRKTSEVAKAI-PDIAIFGSGGIIQGDHALSFLRYGASAFQICSA 828 >UniRef50_Q4DGY9 Dihydroorotate dehydrogenase, putative n=1 Tax=Trypanosoma cruzi RepID=Q4DGY9_TRYCR Length = 280 Score = 127 bits (320), Expect = 5e-28, Method: Composition-based stats. Identities = 48/226 (21%), Positives = 84/226 (37%), Gaps = 25/226 (11%) Query: 39 RQKVPAKPVNCMGLTFKNPLGLAAG-LDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDK 97 QK+ +N + F NP AAG L E + + A G++ + T P+ GN + Sbjct: 43 TQKMMRLKLNLLDHVFANPFMNAAGVLCSTEEDLRCMTASSSGALVSKSCTSAPRDGNPE 102 Query: 98 PRLFRLVDAEGLINRMGFNNLGVDNLVENVKKAHY--DGVLGINIGKNKDTPVEQGKDDY 155 PR + G IN MG NLG D ++ H L ++I ++ Sbjct: 103 PRY--MAVPLGSINSMGLPNLGFDFYLKYASDLHDYSKKPLFLSIS-------GLSVEEN 153 Query: 156 LICMEKIYAYAG----YIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKY 211 + + ++ A + +N+S PN PG + Y A++ + + Sbjct: 154 VAMVRRLAPVAQEKGVLLELNLSCPNVPGKPQVAY------DFEAMRTYLQQVSLAYG-- 205 Query: 212 VPIAVKIAPDLSEEELIQVADSLVRHN-IDGVIATNTTLDRSLVQG 256 +P VK+ P A L + V N+ + ++ Sbjct: 206 LPFGVKMPPYFDIAHFDTAAAVLNEFPLVKFVTCVNSVGNGLVIDA 251 >UniRef50_C1TLU5 Dihydroorotate dehydrogenase family protein n=1 Tax=Dethiosulfovibrio peptidovorans DSM 11002 RepID=C1TLU5_9BACT Length = 302 Score = 127 bits (319), Expect = 6e-28, Method: Composition-based stats. Identities = 68/303 (22%), Positives = 120/303 (39%), Gaps = 37/303 (12%) Query: 42 VPAKPVNCMGLTFKNPLGLAAGLD-KDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRL 100 + V L F NP+ AAG + E + G G I TV+ P KP + Sbjct: 1 MADLTVKLGKLKFINPVLPAAGPNVMRLEQMLEAVERGAGGIVTKTVSREPAV-YPKPCI 59 Query: 101 FRLVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGIN-IGKNKDTPVEQGKDDYLICM 159 + GL+N + + +++ D + + G + +D Sbjct: 60 SKGPCD-GLLNC--------ETWSDRPWRSYIDDYVKVKETGVPLICSIGYSPEDVAELG 110 Query: 160 EKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIA 219 + + A G P+ T G+ LD L + + + P+ +K++ Sbjct: 111 KALEAEVG--------PDVVEFSTHYVGKTLDPLKRVAEALRGSV------SCPVWMKVS 156 Query: 220 PDLSEEELIQVADSLVRHNIDGVIATNTT---LDRSLVQGMK---NCDQTGGLSGRPLQL 273 P S + ++A + + +DG +A N+ LD + + D G LSG + Sbjct: 157 P--STPNIPEMAKVMSDY-VDGFVAVNSVGPALDFDIDKPKPRLGTEDGHGWLSGPAITG 213 Query: 274 KSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIV 333 + + ++S + P++GVGGI + A + I AGASLV I S I +G + +I Sbjct: 214 VALYAVYQISH--SQDKPVVGVGGIRTGEDAVKFIMAGASLVGICSEAIRRGTGIYGKIA 271 Query: 334 THI 336 + I Sbjct: 272 SEI 274 >UniRef50_A3DL41 Dihydroorotate dehydrogenase family protein n=1 Tax=Staphylothermus marinus F1 RepID=A3DL41_STAMF Length = 406 Score = 126 bits (317), Expect = 1e-27, Method: Composition-based stats. Identities = 70/319 (21%), Positives = 120/319 (37%), Gaps = 39/319 (12%) Query: 44 AKPVNCMGLTFKNPLGLAA-GLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFR 102 + V GL KNPL AA + +D E + AL G G++ T++ RP +P + Sbjct: 3 SLEVEIAGLKMKNPLMNAACPVSRDAEMMKALIDNGVGAVVAKTISVRP-AIVPRPSM-- 59 Query: 103 LVDAEGLINRMGFN--NLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKD-DYLICM 159 G++ G +V + +N D P E + +Y I Sbjct: 60 GAVDRGIVRSQILKTFGPGNVRIVNADSGNYRFIYALLNAELWSDIPAEHYFEREYPIVK 119 Query: 160 EKIYAYAGYIAINIS------------SP----NTPGLRTLQYGEALDDLLTAIKNKQND 203 + I+I N T G+ ++ A K + Sbjct: 120 KYAEEKGVPFIISIGYKPEELQLLGPKCQKAGANAIEFSTHYIGKDYRPVVEAAKALREV 179 Query: 204 LQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLD---RSLVQGMKNC 260 + +PI K++P + ++ L + +DG++ATNT + G+ Sbjct: 180 VD------IPIFAKLSP--FTPNIPELVKELEKVGVDGIVATNTIGPALHIDIETGLPIV 231 Query: 261 ---DQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQI 317 + G +SG L+ + ++ + + LP+IGVGGI E AGAS VQI Sbjct: 232 GGPNGYGWMSGPALKPLALAVVAEAAKNTH--LPVIGVGGISKGTDVIEYFMAGASAVQI 289 Query: 318 YSGFIFKGPPLIKEIVTHI 336 + + +G + + I I Sbjct: 290 CTAALIEGLGVFRRIEKEI 308 >UniRef50_UPI0001968A99 hypothetical protein BACCELL_01888 n=1 Tax=Bacteroides cellulosilyticus DSM 14838 RepID=UPI0001968A99 Length = 494 Score = 122 bits (306), Expect = 2e-26, Method: Composition-based stats. Identities = 58/313 (18%), Positives = 115/313 (36%), Gaps = 36/313 (11%) Query: 44 AKPVNCMGLTFKNPLGLAAGLDKDG-ECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFR 102 VN G+ +NP LA+ E G+ + T++ Q PR Sbjct: 101 ELSVNFCGIRCENPFFLASSPVASSFEMCCHAFDAGWAGVSYKTISFY-QSREVSPRFDA 159 Query: 103 LVDAEGLINRMGFNN------LGVDN---LVENVKKAHYDGVLGINIGKNKDTPVEQGKD 153 L + GF N + ++ +K+ + + V+ +I + + D Sbjct: 160 LPGEHPF-SFCGFKNLEQLSPHSAEENFEIIRRLKERYPEKVIIASI-------MGRNCD 211 Query: 154 DYLICMEKIY-AYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYV 212 ++ + A A I N S P + L D L A+ + + Sbjct: 212 EWTVLARMAEEAGADLIECNFSCPQMA-KQGLGSDIGQDQDLIALYTRAT----RKGSRL 266 Query: 213 PIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLV--------QGMKNCDQTG 264 PI K+ P++ EL + + + + + + A NT + + + G Sbjct: 267 PIIAKMTPNIGNMELPAM--TAIANGANSLAAINTVKSITRINTENFSSYPDIGGQSAVG 324 Query: 265 GLSGRPLQLKSTEIIRRLSLELNGR-LPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIF 323 G SG+ ++ + IR L+ + +P+ G+GGI + A + I G + +Q+ + + Sbjct: 325 GYSGQAVKPIALRFIRDLASYPPLKGIPLFGIGGITTWQDALDFILLGCTALQVCTSVME 384 Query: 324 KGPPLIKEIVTHI 336 G +I + + Sbjct: 385 YGYRIIDHLKEGL 397 >UniRef50_B3E2T4 Dihydroorotate dehydrogenase family protein n=1 Tax=Geobacter lovleyi SZ RepID=B3E2T4_GEOLS Length = 398 Score = 121 bits (305), Expect = 3e-26, Method: Composition-based stats. Identities = 61/309 (19%), Positives = 112/309 (36%), Gaps = 40/309 (12%) Query: 50 MGLTFKNPLGLAAGLD-KDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEG 108 +G+ F+NP LA+ + + G+G I T+ P + L + Sbjct: 10 LGVVFRNPFVLASAPPTATADMVRRAFEAGWGGAVIKTLIREP--------VHNLPNRFA 61 Query: 109 LI---NRM-GFNNLGV---------DNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDY 155 I NR+ GF NL + + +K D + +I ++P E Sbjct: 62 AIRHGNRITGFENLELLSEQAPDEWYRAIRCIKADFPDCPIIGSIMGAANSPDEWH---- 117 Query: 156 LICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIA 215 + + A A + +N S P+ G G A+ + +P+ Sbjct: 118 SLALGCQDAGADLLELNFSCPH--GYPERGRGAAIGQNPDYAAQITRWVTDCKEITIPVI 175 Query: 216 VKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLD------RSLVQGMKNCDQT--GGLS 267 K+ ++ + +A+ L G A NT R+L +T GG S Sbjct: 176 PKLTAAVA--NIQNIAEELALAGAHGFCAINTIPSFFGFDLRTLRPKPDIGGKTSYGGYS 233 Query: 268 GRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPP 327 G ++ + + L + LP++ GGI + A E + GA +VQ+ + + G Sbjct: 234 GPGIKPIALRAVSELCQ--SPGLPVMASGGIANGFDAVEFMLLGAPVVQMATEVMLHGFG 291 Query: 328 LIKEIVTHI 336 +I + + Sbjct: 292 IIDRMQQEL 300 >UniRef50_A8QCU3 Dihydroorotate dehydrogenase, mitochondrial, putative n=1 Tax=Brugia malayi RepID=A8QCU3_BRUMA Length = 196 Score = 121 bits (303), Expect = 4e-26, Method: Composition-based stats. Identities = 53/156 (33%), Positives = 74/156 (47%), Gaps = 5/156 (3%) Query: 26 LRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIG 85 L + P + ++ N M + FKNPLGLAAG DKD E I L GFG IE+G Sbjct: 20 LAKHRLLPLFSHSYREHSELNCNVMNMHFKNPLGLAAGFDKDAEAIKGLRESGFGFIEVG 79 Query: 86 TVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLG---VDNLVENVKKAHYDGVLGINIGK 142 TVTP PQ + L EG ++ F + G V V+ + D LG+NIG+ Sbjct: 80 TVTPLPQKDAHNSVVKLLFKDEGYLSCGKFKSAGLSIVYLFVKRAYDRNADVPLGVNIGR 139 Query: 143 NKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNT 178 N + K DY + ++ Y+ +N+ S N Sbjct: 140 NAGFT--ELKVDYSLGAYYFGRFSNYLVVNLGSQNV 173 >UniRef50_Q7N0H1 Similar to dihydroorotate dehydrogenase PyrD n=1 Tax=Photorhabdus luminescens subsp. laumondii RepID=Q7N0H1_PHOLL Length = 289 Score = 119 bits (299), Expect = 1e-25, Method: Composition-based stats. Identities = 56/298 (18%), Positives = 108/298 (36%), Gaps = 39/298 (13%) Query: 48 NCMGLTFKNPLGLAAGLDKD-GECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDA 106 + +G+ KNP+ + +GL D + I A G G++ T+ PR +L Sbjct: 11 DVLGMKIKNPIIVGSGLLSDQAKNIRQFIAHGAGAVVTKTI---------YPRSEKLHTE 61 Query: 107 EGLINRMG-FNN-----LGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICME 160 + + G NN V+ + +++ + L + + + ++P Sbjct: 62 KTYLFSTGMLNNTTYSKKTVEYWLTLLREFKEEQ-LPVIVSIHAESPEALA-----SLAV 115 Query: 161 KIYAYAGY-IAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIA 219 +I A + + IS L + +D + N ++ + P AVK++ Sbjct: 116 RISAVTDAPLELGISC--------LHADDFTEDTPERVFNYTKVVKERTN--TPFAVKLS 165 Query: 220 PDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTG--GLSGRPLQLKSTE 277 + L + V D + ++T + G G SG ++ Sbjct: 166 L---GDNLYGRVQAAVEGGADAITLSDTISGIAFDTANGEALLNGVCGYSGPGIKPMVLA 222 Query: 278 IIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTH 335 I L +PI+G GG+ E + AGA+ VQ+Y+ ++ IV Sbjct: 223 AIYNLRKR-GVTIPILGSGGVQDGNDVHEYLLAGANTVQVYTALHRHMYKTLQRIVHE 279 >UniRef50_B0EHW2 Dihydropyrimidine dehydrogenase, putative n=2 Tax=Entamoeba RepID=B0EHW2_ENTDI Length = 901 Score = 117 bits (294), Expect = 5e-25, Method: Composition-based stats. Identities = 61/351 (17%), Positives = 127/351 (36%), Gaps = 36/351 (10%) Query: 16 ERAHEFTFQQLRRITGTPFEALVRQKVPAK----PVNCMGLTFKNPLGLAAG-LDKDGEC 70 E H+ + + + P V G+ ++NP G+++ + + Sbjct: 405 EAVHDAEVVVASIAKELGVDKIPKFHTPVDDVDISVTVDGIKYENPFGISSAPVSGTYDH 464 Query: 71 IDALGAMGFGSIEIGT--VTPRPQPGNDKPRLFRLVDAE---GLINRMGFNNLGVDNLVE 125 + GFG T + Q N R+ ++ D++ N + + +E Sbjct: 465 LKRCFQAGFGFALTKTYPLEKDIQKNNHI-RIVKVYDSQESTSYNNIVMISEHSHHYWLE 523 Query: 126 NVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPN-------- 177 ++KK + + I E+ A + +N S PN Sbjct: 524 SIKKLKAEFPNKVVIASIMCMDNADDWHLLAKLSEEAG--ADALELNFSCPNECHGNDGN 581 Query: 178 ---TPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSL 234 G A+ ++ ++ + ++P+ K+ P++ + ++A + Sbjct: 582 EGGCEGGFKSHNAMAMAIGVSPAAIERCTRYVVESVHIPVYPKLTPNV--GNIEELAAAA 639 Query: 235 VRHNIDGVIATNTTLDRSLVQ---------GMKNCDQTGGLSGRPLQLKSTEIIRRLSLE 285 +R GV NT S + G++ +GGLSG ++ + I ++ Sbjct: 640 MRGGASGVSTINTVFGISEITLSGHPWPQVGVERNTISGGLSGDLVRPIAIRQIAQVLRH 699 Query: 286 LNG-RLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTH 335 R ++G+GG+ S A + I GAS+VQ+ S ++ EI++ Sbjct: 700 NENVRGHLLGIGGVRSAETAMQLIYTGASVVQMCSSVQKWSYDIVDEIISG 750 >UniRef50_B9UIZ1 Putative dehydrogenase n=1 Tax=Streptomyces flavoviridis RepID=B9UIZ1_9ACTO Length = 326 Score = 117 bits (293), Expect = 6e-25, Method: Composition-based stats. Identities = 65/305 (21%), Positives = 123/305 (40%), Gaps = 24/305 (7%) Query: 34 FEALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDGEC-IDALGAMGFGSIEIGTVTPRPQ 92 A + P V +GL+ NP+ + +GL D E I L G G++ T+ P P Sbjct: 20 IRATAGRSQPMLEVPILGLSPANPVIVGSGLLTDQERNIRRLLGKGAGAVVTKTIHPSPP 79 Query: 93 PGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGK 152 G D+ R+ RL G++N ++ V+ ++ ++ + D L + + DTP E Sbjct: 80 QGLDE-RILRLPV--GMLNSTTYSKRSVNRWLKTLR-SFADDRLPVIASLHADTPGELAM 135 Query: 153 DDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYV 212 +E A + + IS N + + + +++K + Sbjct: 136 --LAKDVETTGCRA--LELGISCLNEEDGLEDDNPDRVYAYTSEVRSKT---------AL 182 Query: 213 PIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTG--GLSGRP 270 P++VK+A E L + + D + ++T ++ + G G SG Sbjct: 183 PMSVKLA---VGEGLRDRVRAAIAGGADAITLSDTIAGAAVSPTTGRLELNGVFGYSGPG 239 Query: 271 LQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIK 330 L+ I +L LP++G GG+ S + ++ GAS+ Q+Y+ ++ Sbjct: 240 LKPLVLAAIWQLRK-SGIALPVMGCGGVSSGRDVADYLSVGASVAQVYTALHTDMYRTLE 298 Query: 331 EIVTH 335 I+ Sbjct: 299 RILAE 303 >UniRef50_A4VL83 Phosphoserine aminotransferase n=1 Tax=Pseudomonas stutzeri A1501 RepID=A4VL83_PSEU5 Length = 485 Score = 117 bits (293), Expect = 7e-25, Method: Composition-based stats. Identities = 40/195 (20%), Positives = 82/195 (42%), Gaps = 9/195 (4%) Query: 140 IGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKN 199 +G + Q + + + +A Y+ +N+ P + L L L LL A+ + Sbjct: 300 LGISLTLDARQASAESRAMLRAAWPHADYLMLNLIGPTSAPL--LSQSTRLRHLLAALVD 357 Query: 200 KQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKN 259 +Q L + VP+ K+ + E +A LV DG++A + + + + Sbjct: 358 EQRQLNQDGRRRVPLLAKLR-CMPERTPFSIAGLLVELGFDGLLAAHDPGPPATAERYRA 416 Query: 260 CDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYS 319 Q + + I L + ++ VGG+ + R +++AGA LVQ+++ Sbjct: 417 WQDPRR------QAHACQQIEDLRRFCGPDMALLSVGGVQTADHLRARMSAGAELVQVHT 470 Query: 320 GFIFKGPPLIKEIVT 334 F+ + P L + ++ Sbjct: 471 AFMHQSPWLARRLLR 485 >UniRef50_A2EKA7 Dihydroorotate dehydrogenase family protein n=3 Tax=Trichomonas vaginalis RepID=A2EKA7_TRIVA Length = 365 Score = 116 bits (291), Expect = 1e-24, Method: Composition-based stats. Identities = 49/298 (16%), Positives = 105/298 (35%), Gaps = 25/298 (8%) Query: 44 AKPVNCMGLTFKNPLGLAAGLD-KDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFR 102 + G KNPL A G +D + G G + T++ +P ++ Sbjct: 2 SLKTKFAGYEVKNPLMPAPGPPVRDAKACIDCIKGGCGVMVTKTISVAAAK-VPQPNMYE 60 Query: 103 LVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKI 162 D + +N + L + +E+ + I + ++ K+ Sbjct: 61 SKDHKYFLNTELWTELTPEQWLEHEYPKIREVCNQAKIPM--ICSMGYTAEEIAKMAPKV 118 Query: 163 YAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDL 222 + + ++ + + D + A P+ VK++P Sbjct: 119 APFCDGLELST-------HYIGDDPKPMQDAIKA--------AIHGSGGKPVYVKLSPFR 163 Query: 223 SEEELIQVADSLVRHNIDGVIATNTTLDRSLVQG----MKNCDQTGGLSGRPLQLKSTEI 278 + A + + V + TL + + M + + G +SG ++ + + Sbjct: 164 DAPIAAKAAKAAGATGLVCVNSFGPTLALDIERKGAPFMGSTSKYGWVSGPAIKPLALRV 223 Query: 279 IRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + + E++ LP++GVGGI + A E + AGA + I + I +G + I + Sbjct: 224 VYDVCKEVD--LPVVGVGGISNGRDAIEFLMAGAQALGICTAAIVEGRDVYGSIAQEM 279 >UniRef50_Q01P61 Dihydropyrimidine dehydrogenase (NADP+) / dihydrouracil dehydrogenase (NAD+) / dihydroorotate oxidase B, catalytic subunit n=94 Tax=Bacteria RepID=Q01P61_SOLUE Length = 446 Score = 116 bits (291), Expect = 1e-24, Method: Composition-based stats. Identities = 60/310 (19%), Positives = 116/310 (37%), Gaps = 27/310 (8%) Query: 42 VPAKPVNCMGLTFKNPLGLAAGLDKD-GECIDALGAMGFGSIEIGTVTPRPQPGNDKPRL 100 + N G+ NP LA+G + GE I G+G T+ P N R Sbjct: 1 MADLSTNFAGIRCPNPFWLASGPPTNCGEQIMRAFDAGWGGAVWKTIG-EPIV-NVSSRY 58 Query: 101 FRLVDAEGLINRMGFNNL------GVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDD 154 + + MG NN+ ++ + + + I + D Sbjct: 59 SSVDWNGQRM--MGLNNIELISDRPIETNLREITEVKKRYPKHAVIASLMVESTREAWHD 116 Query: 155 YLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPI 214 + E A A + +N P+ G+ G A+ + ++ + P+ Sbjct: 117 IVKRSE--DAGADGLELNFGCPH--GMSERGMGAAVGQVPDYSCMITEWVKEVA--RTPV 170 Query: 215 AVKIAPDLSEEELIQVADSLVRHNIDGVIATNTT-----LDRSLVQGMKNCDQT---GGL 266 VK+ P++++ + VA + R D + A NT +D N GG Sbjct: 171 LVKLTPNITD--IRAVARAAKRGRADALSAINTINSITGIDLDTFTPRPNVGGKTSHGGY 228 Query: 267 SGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGP 326 G ++ + ++++++ + LPI G+GGI A E I G VQ+ + + G Sbjct: 229 CGPAVKPIALHLVQQIASDPAVGLPISGIGGIGGWREAAEFILLGCGTVQVCTAAMHYGF 288 Query: 327 PLIKEIVTHI 336 ++++++ + Sbjct: 289 RIVEDMIDGL 298 >UniRef50_A0ADR6 Putative hihydroorotate dehydrogenase n=1 Tax=Streptomyces ambofaciens ATCC 23877 RepID=A0ADR6_STRAM Length = 297 Score = 116 bits (291), Expect = 1e-24, Method: Composition-based stats. Identities = 59/277 (21%), Positives = 113/277 (40%), Gaps = 25/277 (9%) Query: 48 NCMGLTFKNPLGLAAGLDKDGEC-IDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDA 106 +GL +P+ + +GL D E I L G ++ T+ P P P ++ RL RL Sbjct: 6 RILGLRLSSPVVVGSGLLTDQERNIRRLFDDGASAVVTKTIHPDPGPAGEE-RLLRLPT- 63 Query: 107 EGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYA 166 G++N ++ V + +++ DG+ I + ++P E + + + + A Sbjct: 64 -GMLNSTTYSRRPVGDWCAMLRRFADDGLPVIA-SVHAESPDELA--ELADLVGQAGSPA 119 Query: 167 GYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEE 226 + + IS N G LDD + + ++ VP +VK+A + E Sbjct: 120 --LELGISCLN--------EGGGLDDTPERVAAYTDAVRRRT--PVPFSVKLA---AGER 164 Query: 227 LIQVADSLVRHNIDGVIATNTT--LDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSL 284 L + ++ + D + ++T L G G SG ++ I L Sbjct: 165 LRERVEAALACGADAITLSDTVAGLAVDADTGEVRLGGAFGYSGAGIKPLVLAEIFGLRR 224 Query: 285 ELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGF 321 +P++ GG+++ E ++ GA VQ+Y+ Sbjct: 225 A-GLTVPVMASGGVENGRDVAEYLSVGADAVQVYTAL 260 >UniRef50_UPI0001791DE1 PREDICTED: similar to dihydropyrimidine dehydrogenase n=1 Tax=Acyrthosiphon pisum RepID=UPI0001791DE1 Length = 1286 Score = 115 bits (289), Expect = 2e-24, Method: Composition-based stats. Identities = 65/357 (18%), Positives = 114/357 (31%), Gaps = 65/357 (18%) Query: 41 KVPAKPVNCMGLTFKNPLGLAAGLDKD-GECIDALGAMGFGSIEIGTVTPRPQ-PGNDKP 98 V GL F NP GLA+ I G+ T N P Sbjct: 681 DDVDLSVRMCGLRFMNPFGLASAPPTTSAAMIRRAFQAGWAFAVTKTFGLDKDLVTNVSP 740 Query: 99 RLFR-------------------------LVDAEGLINRMGFNNLGVDNLVENVKKAHYD 133 R+ V +N + + ++++ D Sbjct: 741 RIVGLGGHGVGVGSAASGIGPGTLGAGDSDVARNAFLNIELISEKTAAYWLRSIRELKRD 800 Query: 134 GVLGINIGKNKDTPVEQGKDDYLICME-KIYAYAGYIAINISSPNTPG-----LRTLQYG 187 I I +E D+ A A + +N+S P+ G L Q Sbjct: 801 FPQHILIASIMCAYIEN---DWTSLARLACDAGADALELNLSCPHGMGESGMGLACGQDP 857 Query: 188 EALDDLLTAIKNK--QNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIAT 245 ++++ +K + VP+ VKI P++++ + A + DGV A Sbjct: 858 VLVENISRWVKRVAVRPASDGGTPTAVPVFVKITPNVTDVVAVARAAVRL-GGADGVTAV 916 Query: 246 NTT-----------LDRSLVQGMKNCDQT-----GGLSGRPLQLKSTEIIRRLSLELNGR 289 NT R + +T GG+SG ++ + LS L Sbjct: 917 NTVSALGPLDVTGNGGRPWPGVGRTTAETPRTTYGGMSGTAVRPMGLRAVSALSRALGPD 976 Query: 290 ----------LPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + I+ GG+DS A + + GA +VQ+ S + ++++ +T + Sbjct: 977 ATAGGDGGPPVQIMATGGVDSAAATLQYLYCGAKVVQVCSAVQNQDFTIVQDYITGL 1033 >UniRef50_Q23YG3 Dihydroorotate dehydrogenase family protein n=1 Tax=Tetrahymena thermophila SB210 RepID=Q23YG3_TETTH Length = 1080 Score = 114 bits (286), Expect = 5e-24, Method: Composition-based stats. Identities = 59/296 (19%), Positives = 104/296 (35%), Gaps = 26/296 (8%) Query: 41 KVPAKPVNCMGLTFKNPLGLAAGLDKDGE-CIDALGAMGFGSIEIGT-VTPRPQPGNDKP 98 G+ +NP GLA+ I +G+ + T V + N P Sbjct: 618 DDVDISTEICGVKMENPFGLASAPPTTSYPMIARSFDIGYDFAVVKTAVLDKDTVFNVSP 677 Query: 99 RLFRLVDA----EGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDD 154 R+F++ D N + + VE K+ D + IG +Q D Sbjct: 678 RIFKVPDPLRQECSYGNIELVSEKSLKYWVEGAKQIKKDYPNKVLIGSLMAAYNQQ---D 734 Query: 155 YLICMEKIYAYA-GYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVP 213 ++ M ++ I +N+S P+ G+ G A + +++ + +P Sbjct: 735 WIDIMHQVKDAPFDMIELNLSCPH--GMNEKGMGRACGEDPDIVRDITS--WVTSQTKIP 790 Query: 214 IAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQ---------GMKNCDQTG 264 I VKI P+ + E+ +A + V TNT G++ G Sbjct: 791 IIVKITPNYGQAEI--LAKAAYEGGAKAVTLTNTMPGLVDPYPDGESFNGVGVEKNVAPG 848 Query: 265 GLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSG 320 G +G L+ + ++ + + I GGI S + GA +QI S Sbjct: 849 GSTGSILRPFAMRKCVDVAKFV-PEIDIFASGGIISGDHGINYLHYGAKALQICSA 903 >UniRef50_C3KS38 Putative hihydroorotate dehydrogenase n=2 Tax=Clostridium botulinum RepID=C3KS38_CLOB6 Length = 298 Score = 109 bits (272), Expect = 2e-22, Method: Composition-based stats. Identities = 55/298 (18%), Positives = 113/298 (37%), Gaps = 36/298 (12%) Query: 45 KPVNCMGLTFKNPLGLAAG-LDKDGECIDALGAMGFGSIEIGTV---TPRPQPGNDKPRL 100 +G+ KNP+ +A+ L + + I +G G++ T+ Q G R+ Sbjct: 10 LQTEVLGMKLKNPVIIASSNLTDNEKSIRKFLDLGVGAVITKTIYIGEKNIQSG----RI 65 Query: 101 FRLVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICME 160 R + N ++ + E + K + + + I + V KD+ + Sbjct: 66 LR--KESQIFNSTTYSKKSISEWTEILSKLYKENLPVI------PSIVADTKDELVNLAL 117 Query: 161 KIYAYA-GYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIA 219 ++ + + IS PN G+ E + D A+ + VP++VK+ Sbjct: 118 QMEEVGCKALELGISCPNEIGIN-----EKIYDFTRAVCREV---------SVPVSVKLT 163 Query: 220 PDLSEEELIQVADSLVRHNIDGVIATNTTLDRSL-VQGMKNCDQTGGLSGRPLQLKSTEI 278 SE ++ + + V +++ + G G SG ++ + Sbjct: 164 ---SEVKVEEKVRKAMCAGAKSVSISDSIPAIVVNTDGTLPLGVRCGYSGPAIKPIVQKN 220 Query: 279 IRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 I L N + +IG+GGI++ E + G+S V++ S G ++ I+ + Sbjct: 221 IYYLKKN-NADVEVIGIGGIENANDVLEYLYVGSSAVELCSCIFINGINQVERIIHDL 277 >UniRef50_UPI00016C5774 dihydroorotate dehydrogenase 2 n=1 Tax=Gemmata obscuriglobus UQM 2246 RepID=UPI00016C5774 Length = 638 Score = 109 bits (272), Expect = 2e-22, Method: Composition-based stats. Identities = 64/337 (18%), Positives = 114/337 (33%), Gaps = 50/337 (14%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALV------RQKVPAKPVNCMGLTFK 55 Y R L++L A + R+ P L + P V +G F Sbjct: 6 YRTVSRPLLYRLGARTARAVALGFMGRLARLPLGPLAIDLLGHMRADPRLTVRLLGRDFA 65 Query: 56 NPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGF 115 +P+GL GLD +G + A G G I +G V + N R Sbjct: 66 SPIGLGPGLDPEGVALPAFARFGIGFISVGPVGLQ----NPPTR---------------- 105 Query: 116 NNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISS 175 ++ D+ E + LG+ + ++ +A+ +S Sbjct: 106 PSVERDDAREAIGFPDAAPPLGLKAAG--------------AVLAELSRLGVPVAVRVS- 150 Query: 176 PNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLV 235 + E LLT + + V ++ + L+ V Sbjct: 151 --------GETAEEYRHLLTETRRFVAAIAVPAAAAVAMSEWLPAAEGVPILLTVRADSP 202 Query: 236 RHNIDGVIATNTTLDRSLVQGMKNCDQTGGL-SGRPLQLKSTEIIRRLSLELNGRLPIIG 294 +++ + A ++ + GG G P + + ++R L L +P++ Sbjct: 203 TADMEALAAGLAAGAGGVLIDGAVAREGGGTEIGAPAREPALALVRALRASLGPAVPLVV 262 Query: 295 VGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKE 331 GG+ A + AGA LV++ SG +F GP L+K Sbjct: 263 GGGVHEPEHALALLDAGADLVEVDSGLVFNGPGLVKR 299 >UniRef50_B0P959 Putative uncharacterized protein n=1 Tax=Anaerotruncus colihominis DSM 17241 RepID=B0P959_9FIRM Length = 371 Score = 109 bits (272), Expect = 2e-22, Method: Composition-based stats. Identities = 58/298 (19%), Positives = 111/298 (37%), Gaps = 26/298 (8%) Query: 44 AKPVNCMGLTFKNPLGLAAG-LDKDGECIDALGAMGFGSIEIGT-VTPRPQPGNDKPRLF 101 KP++ MGL KNPL +AAG I G ++ T V P PR++ Sbjct: 2 TKPISFMGLALKNPLIVAAGPWSGGAAAIQKCIDAGAAAVITETIVMEEPWL--FSPRIY 59 Query: 102 RLVDAEGLINRMGFNNLGVDNLVENVKKAHYDGV-LGINIGKNKDTPVEQGKDDYLICME 160 + L+N + ++ V++ D L +I + + + E Sbjct: 60 --YHDDELLNLSLYGKRTLEEWEGEVERVRKDSCHLICSIRASSPSEIAYIAQ----RTE 113 Query: 161 KIYAYAGYIAINISSPNTPGLRTLQ-YGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIA 219 ++ A + +++ +P + + E L + + A + +P+ ++ Sbjct: 114 RLG--ADALQLDLYAPMDSMIEDIHLQPEKLYEFVHAAASAV---------SIPVMTRLP 162 Query: 220 PDLSEEEL-IQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEI 278 +L+ + + I + + L GG +GR ++ S Sbjct: 163 YNLAASAPHLHAVERAGLRAICAIESLRALSGVDLETQTTLMPTYGGYTGRHIRPISLAA 222 Query: 279 IRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 L+ + LPI GVGG++ + E I GA+ Q+ S + G LI + V + Sbjct: 223 TATLAQLTD--LPICGVGGVEDYRSILEFIMLGAAAAQLGSAIMLHGYDLITKTVRAL 278 >UniRef50_A2ELU8 Dihydroorotate dehydrogenase family protein n=3 Tax=Trichomonas vaginalis RepID=A2ELU8_TRIVA Length = 811 Score = 109 bits (272), Expect = 2e-22, Method: Composition-based stats. Identities = 67/327 (20%), Positives = 127/327 (38%), Gaps = 51/327 (15%) Query: 44 AKPVNCMGLTFKNPLGLAAG-LDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFR 102 + G+ FKNP G+++ + ECI G G T+ P + FR Sbjct: 363 SLETEFCGMKFKNPSGISSAPVSGTYECIRNCFKAGMGWAVTKTI--LPTKDVIRENDFR 420 Query: 103 LVDAEGLINRMGFNNLGV---------------DNLVENVKKAHYDGVLGINIGKNKDTP 147 +V A+ N G + ++ +KK + + + + Sbjct: 421 IVKAD--------ENPGPSGSFCNICMMTEHTEEYWLDTIKKLKAEFPDRVLVASIATSD 472 Query: 148 VEQGKDDYLICMEKIYAYAGYIAINISSPN-------TPGLRTLQY--GEALDDLLTAIK 198 ++ + + + I A A + +N+S PN G + G AL ++K Sbjct: 473 SKERWQNLVKNV--IAAGADALELNLSCPNEVHGEGGCKGGFDTENKIGMALGTHPISVK 530 Query: 199 NKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQ--- 255 ++ VP VK+ P++++ I +A + + DGV NT + Sbjct: 531 RISQYVKEAT--TVPFFVKLTPNITDP--IDIAQAALEGGADGVAMINTVSGIAKFWPDG 586 Query: 256 ------GMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIA 309 G + +GGLSG ++ + I R+ + +PI+G+GGI S A + + Sbjct: 587 TPLPQVGKEKYVLSGGLSGDQVRPIALRQISRVHNKF-PEMPILGIGGIGSGYTALQHLY 645 Query: 310 AGASLVQIYSGFIFKGPPLIKEIVTHI 336 AG+S+ Q+ S +++E+ + Sbjct: 646 AGSSVFQMCSAIQRYSYDIVREVNAGL 672 >UniRef50_A0DS83 Chromosome undetermined scaffold_61, whole genome shotgun sequence n=1 Tax=Paramecium tetraurelia RepID=A0DS83_PARTE Length = 388 Score = 108 bits (270), Expect = 3e-22, Method: Composition-based stats. Identities = 66/343 (19%), Positives = 130/343 (37%), Gaps = 93/343 (27%) Query: 52 LTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLIN 111 + KN LGLA+G D DG ++ L +GFG IEIG++T + R R + +N Sbjct: 77 IKLKNQLGLASGFDNDGSFVETLQNLGFGFIEIGSITAQ--------RNIRFSED---LN 125 Query: 112 RMGFNNLGVDNLVE--------------NVKKAH-YDGVLGINIGKN----KDTPVEQGK 152 N ++ L E ++++ + +G++I + K TP + Sbjct: 126 TYSVKNDSIEYLSEIPQMGILQSKAILTSLRRNYAIKIPVGVSIMPSEEIYKYTPY-LIE 184 Query: 153 DDYLICMEKIYAYAGYIAIN-ISSP------------NTPGLRTLQYGEALDDL----LT 195 +D ++ A ++ +N +SS NT ++ + + + L Sbjct: 185 NDISNVTRELCTVADFLVLNLVSSQRTSKLYNDIVTNNTDVIKKMIQSIQITQIEEIGLQ 244 Query: 196 AIKNKQNDLQAMHHKYV-------------------------PIAVKIAPDLSEEELIQV 230 A + + V P+ +K++ ++ + L + Sbjct: 245 AALEHETKNELKGDNQVREYLSTTQLGLKQQYLFNIIRNLVAPLYIKVSSNIQKTILDFL 304 Query: 231 ADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRL 290 + + I G+I L + ++++ +L Sbjct: 305 LEEAKGNKIQGIILQKDINQNDLEY--------------------NKTLKQVRQQLPKSC 344 Query: 291 PIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIV 333 +I VGGI + + +E++ GA QI+S F+ KGP +IK+I+ Sbjct: 345 TLISVGGIKTKVQFQERLNNGADACQIFSSFVAKGPHVIKDIL 387 >UniRef50_UPI0000D54A55 dihydroorotate dehydrogenase n=1 Tax=Psychroflexus torquis ATCC 700755 RepID=UPI0000D54A55 Length = 106 Score = 107 bits (267), Expect = 6e-22, Method: Composition-based stats. Identities = 38/108 (35%), Positives = 71/108 (65%), Gaps = 4/108 (3%) Query: 227 LIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLEL 286 ++++ I G+I +NT++D+ +++G + GG+SG+PL +S ++++ + E Sbjct: 2 ILKIVSIHKTLKIKGLIVSNTSIDKDILEGCSH---EGGISGKPLFKRSNQLLKMIH-EF 57 Query: 287 NGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVT 334 + + ++GVGG+ S KI GASLVQIY+GFIF+GP ++K+I++ Sbjct: 58 DKDIFLVGVGGVFSKEDYENKINLGASLVQIYTGFIFEGPAIVKKILS 105 >UniRef50_P07670 Dihydroorotate dehydrogenase n=1 Tax=Dictyostelium discoideum RepID=PYRD_DICDI Length = 370 Score = 107 bits (267), Expect = 8e-22, Method: Composition-based stats. Identities = 53/327 (16%), Positives = 122/327 (37%), Gaps = 49/327 (14%) Query: 39 RQKVPAKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKP 98 K P+K ++ +G +P+G+ AG + + + GF T+ G+ P Sbjct: 36 DNKDPSKYIDFLGQKLASPIGVPAGPLLNSQWVKFALEAGFDLPTYKTIRSHEHFGHPVP 95 Query: 99 RLFRL---------------------------VDAEGLINRMGFNNLGVDNLVENVKKAH 131 + L +D + N G ++G + L +++ AH Sbjct: 96 NVMYLDLESEDKQFTKSDSGSTLHATQTIPTTMDQLAITNSFGMPSMGKEYLYKDIALAH 155 Query: 132 Y----DGVLGINIGKNKDTPVEQGKDDYLICME-KIYAYAGYIAINISSPN--TPGLRTL 184 + ++I + D++ + A A + +N S PN T + Sbjct: 156 SYLGSGQSMIVSITGTASSA-HDFLQDFVDTVRIACDAGAKMVEVNYSCPNVVTGEGQIY 214 Query: 185 QYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIA 244 +A+ ++ + + ++ + K +P+ +K+ E++ ++ R + + Sbjct: 215 HNPDAVYEISSTL------VKELSSKNIPLIIKVGVMDDLEKMERLFQQAERAGVAAIAG 268 Query: 245 TNT-----TLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLS---LELNGRLPIIGVG 296 NT T + + T G+ G P++ + + + S + N +L ++G G Sbjct: 269 INTLSMKVTDKITGEPSLGASRLTSGVCGAPIRSAALDWVSTASSIIKKQNSKLKLLGCG 328 Query: 297 GIDSVIAAREKIAAGASLVQIYSGFIF 323 GI + + +GA + +G ++ Sbjct: 329 GIVKPEHFDDFLNSGADIAMSATGLMW 355 >UniRef50_Q972L2 350aa long hypothetical dihydroorotate dehydrogenase n=1 Tax=Sulfolobus tokodaii RepID=Q972L2_SULTO Length = 350 Score = 105 bits (263), Expect = 2e-21, Method: Composition-based stats. Identities = 54/311 (17%), Positives = 109/311 (35%), Gaps = 33/311 (10%) Query: 44 AKPVNCMGLTFKNPLGLAAG-LDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFR 102 V G+TF NP + +G + I + G+G + + T+ + +P Sbjct: 3 DLSVTFQGITFPNPFLVGSGPTTGNPPKIISAIRAGWGGVVVKTIGDSIVRKSVRPMYAT 62 Query: 103 LVDAEGLI---NRMGFNNLGVDNLVENVK----KAHYDGVLGINIGKNKDTPVEQGKDDY 155 + +I N ++ + ++ + + ++I D ++ Sbjct: 63 IRRNREIIAFENLELITEDPLEVWDKYLRVIKSEIGKSAPIIVSIMGGPD------YSEW 116 Query: 156 LICMEKIYAY-AGYIAINISSPNT-PGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVP 213 + A + +N P+ P RT + DL+ + + +P Sbjct: 117 IRLARWAEDRGADMLELNFGCPHGEPEKRTGAFIGQHADLVQEYTKEV-----VSSVGIP 171 Query: 214 IAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLV--------QGMKNCDQTGG 265 + K+ P++++ + + A + V A NT V + GG Sbjct: 172 VIAKLTPNITD--IRETAKAAENAGAKAVTAINTVNGVIAVDIERAQPLPDINGYSGYGG 229 Query: 266 LSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKG 325 +SG ++ + ++ + ++ GVGGI A E I GA+ VQ + I KG Sbjct: 230 ISGPAVKPIGLAAVSKIYTSTSLQIS--GVGGIFDWRDAVEYIMMGATTVQSVTYTILKG 287 Query: 326 PPLIKEIVTHI 336 I E + Sbjct: 288 FEFINEWKKEL 298 >UniRef50_A8F8E8 Dihydroorotate dehydrogenase n=1 Tax=Thermotoga lettingae TMO RepID=A8F8E8_THELT Length = 386 Score = 104 bits (261), Expect = 4e-21, Method: Composition-based stats. Identities = 62/317 (19%), Positives = 122/317 (38%), Gaps = 53/317 (16%) Query: 44 AKPVNCMGLTFKNPLGLAA-GLDKDGECIDALGAMGFGSIEIGT--------VTPRPQPG 94 +G+ KNP+ +A+ GL ++ + + G + + ++P P+ Sbjct: 2 DLSCEYVGIKLKNPIIVASSGLAENLKNMKKAEEHGAACVVAKSLFEEKICRISPTPR-- 59 Query: 95 NDKPRLFRLVDAEGLINRMG-FNNLGVDNL-----------VENVKKAHYDGVLGINIGK 142 F +++ + MG + + E ++KA L I + Sbjct: 60 ------FEIIERK-----MGKLRSQTFYSFEQASPFDAHEYFEEIRKAV--NTLSIPVIP 106 Query: 143 NKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQN 202 + + ++G Y E A A + +N+S P+ G + + G+ + +L+ K ++ Sbjct: 107 SINCVTDEGWSQYARMAEGAGAPA--LELNVSCPH--GSISFRGGDVEEKILSVAKIVRD 162 Query: 203 DLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSL-VQGMKNCD 261 ++ +P+ VK+ LS + +A L R IDGV+ N + ++ + Sbjct: 163 SVK------IPLIVKLPMQLSSP--LSMAKMLERSGIDGVVMFNRLTGLDINLEKERPVL 214 Query: 262 QTG--GLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYS 319 G G G I S LN + + GG+ S + I AGA+ V++ S Sbjct: 215 HEGYAGHGGPWAFNYVLRWIAASSPHLN--ISVAASGGVGSGEDIIKYIYAGANAVEVCS 272 Query: 320 GFIFKGPPLIKEIVTHI 336 G I ++ I Sbjct: 273 LIYLSGYEAIDMLLEQI 289 >UniRef50_A6CFX5 Putative uncharacterized protein n=1 Tax=Planctomyces maris DSM 8797 RepID=A6CFX5_9PLAN Length = 354 Score = 103 bits (257), Expect = 9e-21, Method: Composition-based stats. Identities = 67/334 (20%), Positives = 119/334 (35%), Gaps = 45/334 (13%) Query: 38 VRQKVPAKP--VNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGN 95 V ++VP+ P + GL +PLG+ AG +G+ + ++GF + TV + Sbjct: 27 VDREVPSFPGCWSFCGLPVPSPLGIPAGPLLNGKWVLYYASLGFDVLTYKTVRSSSRACY 86 Query: 96 DKPRLFRLVDA----------------EGLINRMGFNNLGVDNLVENVKKAHYD----GV 135 P L + + G + D +V++ Sbjct: 87 PLPNLQPVQTSSLEGTETAVKLSAEMQGSWAVSFGMPSAEPDVWRRDVEQTRKQLSAEKR 146 Query: 136 LGINIGKN--KDTPVEQGKDDYLICME-KIYAYAGYIAINISSPN--TPGLRTLQYGEAL 190 L +++ + D +E DDY C + I + A + N S PN T + Q EA Sbjct: 147 LSVSVVGSLQPDWSLEDLADDYARCAKWAIESGADCVETNFSCPNVCTRDGQLYQQPEAA 206 Query: 191 DDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLD 250 + + +K VP +KI + E +++ G++ TN+ Sbjct: 207 ALVASRVKAV--------SGTVPYLIKIGHLSQKAEAHAFLQAVLPFAA-GIVMTNSVAT 257 Query: 251 RSLVQGMKN--CDQTGGLSGRPLQLKSTEIIR---RLSLELNGRLP---IIGVGGIDSVI 302 + + G+ G + S +R L EL P +I GGI S Sbjct: 258 TVVDDQGTPLFSGEQRGICGAATRQASLNQLRLFTELIAELPADQPRPDLISCGGIGSAS 317 Query: 303 AAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 R +AAGA+ + + P + +I + Sbjct: 318 DVRTFLAAGANATHLATA-AMCDPLIACQIRKEL 350 >UniRef50_A8L1Y0 Dihydroorotate oxidase n=4 Tax=Frankia RepID=A8L1Y0_FRASN Length = 321 Score = 103 bits (256), Expect = 1e-20, Method: Composition-based stats. Identities = 63/314 (20%), Positives = 114/314 (36%), Gaps = 36/314 (11%) Query: 47 VNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDA 106 V G+ ++P+ AAG K E + AL ++ +G++T + GN + Sbjct: 4 VTLAGVALEHPIMNAAGTCKTVEDVTALARGAVAAVVVGSITRDARTGNGGEVYW--SGG 61 Query: 107 EGLINRMGFNNLGVDNLVENVKK-----AHYDGVLGINIGKNKDTPVEQGKDDYLICMEK 161 +N +G N G+ E + Y L +++ ++Y Sbjct: 62 SYSLNALGLPNRGIGYYAEQLPAMADIAHGYGKPLVVSVAGF-------AAEEYATLARV 114 Query: 162 IYAY-AGYIAINISSPNTPGLRT---------LQYGEALDDLLTAIKNKQNDLQAMHHKY 211 A I +N+ PN + Q + A+ + H + Sbjct: 115 AADTGADLIELNLGCPNVWDGGSQKRIACFDLGQTDAICAQVEAALAGGRAG--PGHRRA 172 Query: 212 VPIAVKIAPDLSEEELIQVADSL-----VRHNIDGVIATNTTLDRSLVQGMKN---CDQT 263 VK++P E L +A L V A NT + ++ + Sbjct: 173 PAYGVKVSPFSDPEALADLAALLGRRSEADGGPRFVTAVNTFPNALVLDDRRRPVLDVAL 232 Query: 264 GGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIF 323 GLSG L+ +R+L L ++ ++GVGG+ + +AAGA VQ + F Sbjct: 233 AGLSGAALKPVGLGQVRQLRALLPEQVDVVGVGGVLGGRDVADYLAAGARAVQGATAFWN 292 Query: 324 KG--PPLIKEIVTH 335 +G P + +I++ Sbjct: 293 RGEDPTVFGDILSD 306 >UniRef50_Q871G0 Related to dihydroorotate dehydrogenase a n=3 Tax=Sordariaceae RepID=Q871G0_NEUCR Length = 404 Score = 101 bits (251), Expect = 5e-20, Method: Composition-based stats. Identities = 58/302 (19%), Positives = 103/302 (34%), Gaps = 69/302 (22%) Query: 104 VDAEGLINRMGFNNLGVDNLVENVK---------KAHYDGVLGINIGKNKD------TPV 148 +N +G++ L + ++ ++ + G +IG++K Sbjct: 99 PTQNATLNSLGYSPLPLQTYLDFIRTIAVYHSPPPPPPNNHKGRSIGRSKTIIISVTGSA 158 Query: 149 EQGKDDYLICMEKIYAY-------------AGYIAINISSPNTPGLRTLQY-GEALDDLL 194 E YL + + IN+S PN P Y +AL L Sbjct: 159 EDVAQCYLHIARLQSEFLYVTSSSSPSFVVKVAMEINLSCPNIPHHPPPAYSRDALVRYL 218 Query: 195 TAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSL-------------------- 234 +K +A +P+ +K P E + + + ++L Sbjct: 219 EELKKAIKAAEAEGLPRIPVGLKTPPYTYETQFLGLMEALEASASATALASERNKKQEEK 278 Query: 235 -VRHNIDGVIATNTT------------LDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRR 281 ++ I + ATNT D + TGGL+G PL + ++ Sbjct: 279 ELQCPITFLTATNTLGSCLAFTAFTGFTDDFTQAALPTDLGTGGLAGAPLHPLALGNVKT 338 Query: 282 LSLEL-------NGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVT 334 L L R+ IIGVGG+ + AGA +V + SG + +G + +EI Sbjct: 339 LRKMLDEREKTLGHRIQIIGVGGVLDAQGYKRMRMAGADVVGLASGLLLRGVKVFEEIEK 398 Query: 335 HI 336 + Sbjct: 399 GV 400 >UniRef50_UPI0001C36786 dihydroorotate dehydrogenase family protein n=1 Tax=Clostridium hathewayi DSM 13479 RepID=UPI0001C36786 Length = 307 Score = 98.4 bits (244), Expect = 3e-19, Method: Composition-based stats. Identities = 49/304 (16%), Positives = 105/304 (34%), Gaps = 39/304 (12%) Query: 46 PVNCMGLTFKNPLGLAAGLDKD-GECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLV 104 P + + KNPL AA + E G++ ++ G P + + + Sbjct: 8 PSSIGDIHLKNPLMPAAATLGNLIEHARYFDLNELGAMMPNSMFID--SG--SPTMAKKI 63 Query: 105 --DAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKI 162 G I+ + NN+ + + + + I + + ++ +E++ Sbjct: 64 CKTNNGFISALSKNNMSIFEFEKEILPHLPCETTPLII--DMKAVDKYQMEELAASIEQM 121 Query: 163 YAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDL 222 G I IN++ P PG + + L DL+ ++ + K+ Sbjct: 122 DRIMG-IEINLNCPYGPGTPYWKNPDELKDLVARVRAAAPHKW--------LIAKVPG-- 170 Query: 223 SEEELIQVADSLVRHNIDGVIA----------TNTTLDRSLVQGMKNCDQTGGLSGRPLQ 272 + + +++ + D + + T R G + Sbjct: 171 GDIPVEEISVACQEGGADAITSYSSLNGSCIDIRTGTYRCGGGGSGGFSG------PAFK 224 Query: 273 LKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 + RR + ++ +P+IG+GGI E I AGA VQ+ S + + P + + Sbjct: 225 PVGILMCRRAATAVD--IPVIGIGGISCAEDVIEYIMAGAYAVQVGSANLSR-PDFMHRL 281 Query: 333 VTHI 336 + + Sbjct: 282 LKDL 285 >UniRef50_C0CVL1 Putative uncharacterized protein n=1 Tax=Clostridium asparagiforme DSM 15981 RepID=C0CVL1_9CLOT Length = 291 Score = 98.4 bits (244), Expect = 4e-19, Method: Composition-based stats. Identities = 52/287 (18%), Positives = 105/287 (36%), Gaps = 32/287 (11%) Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAE-GLINRMGFNNLG 119 AAGL E G++ ++ G+ R +L AE G I +G N+LG Sbjct: 4 AAGLGDLIEYGKYYDLSLLGALMPNSIMLE--SGSVS-RARKLYGAEYGYITSLGSNSLG 60 Query: 120 VDNLVENVKKA--HYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSP- 176 V V+ + + L +N+ K +E L I IN++ P Sbjct: 61 VMEYVKKIAVHLPWRESPLILNL---KAEDLEGLVR--LAGTAAGCREVAGIEINMNCPY 115 Query: 177 ---NTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADS 233 T + + L +++ ++ + + +K+ + ++ +A Sbjct: 116 SMAATDPRQYWRDYGWLREMIRGVREAAGEKL--------LIIKVP--TTMVDVEDIAAI 165 Query: 234 LVRHNIDGVIATNTTLDRSLVQGMK----NCDQTGGLSGRPLQLKSTEIIRRLSLELNGR 289 + DG + ++ + +GG G L+ + R+ ++ Sbjct: 166 VKECGADGFTSFGALTGCAIDVRTREFRCGNSGSGGYCGPGLKPLALWSCSRVHKAVD-- 223 Query: 290 LPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 +PI GG+ + E I AGA +VQ+ S + + P + ++ + Sbjct: 224 IPIFSAGGVTNADDVIEHIMAGAWMVQVGSANLTR-PDFMPRLIESL 269 >UniRef50_A3ETM0 Dihydroorotate dehydrogenase n=3 Tax=Leptospirillum RepID=A3ETM0_9BACT Length = 368 Score = 95.7 bits (237), Expect = 2e-18, Method: Composition-based stats. Identities = 64/318 (20%), Positives = 114/318 (35%), Gaps = 49/318 (15%) Query: 46 PVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLV- 104 ++ MG + LG+ AG + I G MGF + TV P P + Sbjct: 36 RIDFMGEKVSSRLGIPAGPLLNSRWISFYGQMGFDILTYKTVRSHFHPSYPDPNCMYVPF 95 Query: 105 ------------------------DAEGLINRMGFNNLGVDNLVENVKKA----HYDGVL 136 + N G + D + +V +A VL Sbjct: 96 HKSFDLEDLQHPLIGTMAYNPVSLTDITITNSFGMPSQHPDIWMRDVGEALSSLSSGQVL 155 Query: 137 GINIGKNKDTPVEQGKDDYLICMEKIYAY-AGYIAINISSPNTPGLRT--LQYGEALDDL 193 +++ + + D++ A + +N S PN G Q +A ++ Sbjct: 156 VLSLVGTQREERDLA-QDFVYTAHLAKETGAKILEVNFSCPNVKGKEGQLYQNPDASGEI 214 Query: 194 LTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSL 253 L I+ + + + +KI + E L ++ ++ + +D + A NT + Sbjct: 215 LKRIRKEL-------GRDFHLIMKIGFSDNPEHLDRLVEATSPY-LDAISAINTVTGTII 266 Query: 254 -VQGMKNCDQTG----GLSGRPLQLKSTEIIRRLSLELNGRLP---IIGVGGIDSVIAAR 305 +G G GL G ++ S + IR L L R P +IGVGG ++V Sbjct: 267 NPEGKPALPGPGRERSGLCGSGIKNLSLKTIRGLKQALRRRAPQLSLIGVGGFNTVEDYP 326 Query: 306 EKIAAGASLVQIYSGFIF 323 + AGA +V +G ++ Sbjct: 327 DFREAGADIVMSATGAMW 344 >UniRef50_A8PKY4 Dihydroorotate dehydrogenase (Dihydroorotate oxidase)(Dhodehase) (Dhodase) (Dhod) n=1 Tax=Rickettsiella grylli RepID=A8PKY4_9COXI Length = 355 Score = 94.2 bits (233), Expect = 5e-18, Method: Composition-based stats. Identities = 64/332 (19%), Positives = 123/332 (37%), Gaps = 47/332 (14%) Query: 29 ITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVT 88 I+ TP + K V+ +G + + +G+AA G+ I L +GF + T+ Sbjct: 24 ISVTPTLRIWPDKTQW--VSFLGYSLASKIGVAACAVTTGKGIALLAQLGFDILTYKTIR 81 Query: 89 PRPQPGNDKPRLFRLVDAE-----------------------GLINRMGFNNLGV---DN 122 + P + P + + + + N G G Sbjct: 82 CKAYPTHPLPNIVPIQVDKQFDYSDLDEVVSTKKIIEINNKIAISNSFG---NGCLEPRV 138 Query: 123 LVENV---KKAHYDG-VLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNT 178 +++++ K A DG VL +++ + +D + A A I +N S PN Sbjct: 139 VMQDIAFSKSALVDGQVLIVSVYGEGHSLSAMSQDFMTAALMAKEAGADIIELNFSCPN- 197 Query: 179 PGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHN 238 ++ E L + + + +P+ +KI E +++ S R Sbjct: 198 ----LMKSDEPLYRNMDCVSQITTRVVKCVG-DIPLLLKIGFIHEHEFPLKLLISAARAG 252 Query: 239 IDGVIATNTTLDRSLVQGMKNC---DQTGGLSGRPLQLKSTEIIRRLSLELNGR---LPI 292 + G+ A N+ R L Q + G+SG P++ + + +++L+ L I Sbjct: 253 VRGISAINSISMRVLNQNHRPAFGKRIYSGISGYPIRRLALQSVKKLTQINQKEKLNLTI 312 Query: 293 IGVGGIDSVIAAREKIAAGASLVQIYSGFIFK 324 +G+GGI E GA V +G ++ Sbjct: 313 VGMGGITVAEHFDEFFDRGADAVLSATGVMWN 344 >UniRef50_D2M1S9 Dihydroorotate dehydrogenase n=1 Tax=Bacillus cellulosilyticus DSM 2522 RepID=D2M1S9_BACS4 Length = 595 Score = 91.1 bits (225), Expect = 5e-17, Method: Composition-based stats. Identities = 65/343 (18%), Positives = 117/343 (34%), Gaps = 76/343 (22%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALV------RQKVPAKPVNCMGLTFK 55 Y+ + L ++ + EF + + I P + + P G+TF Sbjct: 6 YHLLFKPVLKRIPTYYSREFIHRGMNTIASVPGGKGLINFLGREESDPRLQKEIDGITFP 65 Query: 56 NPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLI---NR 112 N +GL+ +D +A +GFG +EIG VT + GN + + + E I + Sbjct: 66 NSIGLSGKIDPLLTGTNAFSNLGFGFLEIGPVTISERDGN----IPEVNEKEQYIIFPEK 121 Query: 113 MGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAIN 172 +G ++G++ VE ++ Y + + + + + M ++ +A + Sbjct: 122 IG--SIGLEKTVEKLRNNSYAQPIFVRVNGTAS--------EVIDMMTELEPFADAYIV- 170 Query: 173 ISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVA- 231 E L L H P+ + + + + A Sbjct: 171 -------------DHEILKKLPE------------LHIKKPLYTRFSVHEIPSNVDERAH 205 Query: 232 DSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLP 291 ++ N TL V+ ++ GG S Sbjct: 206 GIILEEVATFQDYENRTLLIDAVEQLR----YGGFS----------------------KT 239 Query: 292 IIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVT 334 +I VGGI A + AGA LV + G++F GP L K I Sbjct: 240 MITVGGIIEPNDAIDLFHAGADLVMLSGGYVFSGPGLPKRIKE 282 >UniRef50_B3E020 Dihydroorotate dehydrogenase fused to Fe-S-cluster domain n=1 Tax=Methylacidiphilum infernorum V4 RepID=B3E020_METI4 Length = 387 Score = 90.3 bits (223), Expect = 8e-17, Method: Composition-based stats. Identities = 37/225 (16%), Positives = 91/225 (40%), Gaps = 24/225 (10%) Query: 124 VENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKI-YAYAGYIAINISSPNTPGLR 182 ++ VK+ + L ++ E + + +KI + A I +N P+ G+ Sbjct: 38 IQEVKRLWPNRALIVS------MMEEYDRKKWEELAQKIEGSGADGIELNFGCPH--GMP 89 Query: 183 TLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGV 242 G + + ++ + +P+ VK+ P++++ + +A + + + Sbjct: 90 ERGTGSKIGQDPARCAEVTSWVRRVT--SLPLIVKLTPNVTD--ISCIARAAIAGGASAL 145 Query: 243 IATNT---TLDRSLVQGMKNCDQTG-----GLSGRPLQLKSTEIIRRLS--LELNGR-LP 291 NT L + G G SG ++ + + +++ E+ + L Sbjct: 146 SLINTLESILGVDIDTFEVLPSIAGKSSHSGYSGEAIKPIALNLTAKVASMEEVQKKGLA 205 Query: 292 IIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 I +GGI S E + GA+ +Q+ + + KG + +++++ + Sbjct: 206 ISAMGGISSWRDGVEFLLLGATSLQLCTSVMLKGFRIAEDLLSGL 250 >UniRef50_B8E1W3 Dihydroorotate dehydrogenase n=3 Tax=Bacteria RepID=B8E1W3_DICTD Length = 390 Score = 89.5 bits (221), Expect = 1e-16, Method: Composition-based stats. Identities = 58/309 (18%), Positives = 113/309 (36%), Gaps = 37/309 (11%) Query: 44 AKPVNCMGLTFKNPLGLAA-GLDKDGECIDALGAMGFGSIEIGTVTPRP--QPGNDKPRL 100 + +GL KNP+ +A+ GL ++ + + G G++ + ++ + PR Sbjct: 2 DLSCSYVGLRLKNPIIIASSGLTENLKNMKKCEENGAGALVVKSLFEEEICRVS-PTPR- 59 Query: 101 FRLVDAEGLINRMG-FNNLGVDNLVENV---------KKAHYDGVLGINIGKNKDTPVEQ 150 F ++ MG + + + + + VL I + + + + Sbjct: 60 FEIISR-----SMGPLRSQTFYSFEQASPFEPEEYFKEISKALSVLSIPVIPSINCITDD 114 Query: 151 GKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHK 210 G Y E++ A A + +N+S P+ Q + + +L + + +++ Sbjct: 115 GWLKYSKMAEEVGAPA--LELNVSCPHASISFRGQDVD--ETILHVARIVRENVK----- 165 Query: 211 YVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGL---S 267 +PI VK+ LS + VA +L +DGV+ N + + GG Sbjct: 166 -IPIVVKLPMQLSSP--LAVAKALENIGVDGVVMFNRLTGLDINLDTEKPILHGGYAGHG 222 Query: 268 GRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPP 327 G I L + G + S + I GA +VQI S G Sbjct: 223 GPWAFNYVLRWISTSRPHLKLSIAGSGG--VGSGDDVAKYILTGADVVQICSIVYLMGYE 280 Query: 328 LIKEIVTHI 336 +I I+ + Sbjct: 281 IIPRIIDGL 289 >UniRef50_B0UTZ1 Dihydroorotate dehydrogenase n=5 Tax=Pasteurellaceae RepID=B0UTZ1_HAES2 Length = 328 Score = 89.1 bits (220), Expect = 2e-16, Method: Composition-based stats. Identities = 57/250 (22%), Positives = 104/250 (41%), Gaps = 30/250 (12%) Query: 110 INRMGFNNLGVDNLVENVK------KAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIY 163 +N +G + + + ++ K + I++ + + E + + E Sbjct: 81 LNTIGLSPNNLATTIRFIRTISDELKTTSNKPFIISVFGSPEEVGECYEQIVTLQTEVKM 140 Query: 164 AYAGYIAINISSPNTPGLRTLQYG-EALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDL 222 A + INIS PN PG + Y E L L A++ L ++ + +PI +KI P Sbjct: 141 PLA--MEINISCPNMPGEISPAYAAEELLPYLNALQTTLAKL-SLGEEALPIGIKIPPFT 197 Query: 223 SEEELIQVADSLVRH-------NIDGVIATNTTLDRSLVQGMK------NCDQTGGLSGR 269 + + ++ + L++ I + +TNT ++Q K GGL+G Sbjct: 198 YQNQYDELINGLLKSLTENKTLPISFITSTNTLGSSLVMQEGKSILNSETGTGIGGLAGT 257 Query: 270 PLQLKSTEIIRRLSLELNG-----RLPIIGVGGIDSVIAAREKIA-AGASLVQIYSGFIF 323 + S + L L+ L IIGVGG++ A E++ AGA+ V + + Sbjct: 258 AIHALSLGNVYTLRQMLDKEPKLKDLQIIGVGGVND-KAGFERMKTAGANFVGLATALGV 316 Query: 324 KGPPLIKEIV 333 KG + EI+ Sbjct: 317 KGIHVFAEIL 326 >UniRef50_D2Q7Y3 Pyr Dihydroorotate dehydrogenase n=16 Tax=Bacteria RepID=D2Q7Y3_9BIFI Length = 375 Score = 88.4 bits (218), Expect = 4e-16, Method: Composition-based stats. Identities = 65/332 (19%), Positives = 111/332 (33%), Gaps = 52/332 (15%) Query: 48 NCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLF------ 101 + +G P G+ AG + A MGF TV R N P + Sbjct: 53 DFLGFHVNLPFGIPAGPLLNERFTTAAFRMGFDLAVYKTVRSRAWGCNAFPNVLAVHPKN 112 Query: 102 --------------------RLVDAEGLINRMGFNNLGVDNLVENVKKA------HYDGV 135 R + N G + D ++KKA V Sbjct: 113 ADGSLIPGSAELDEGVLADTRYELPISISNSFGVPSRDPDEWQPDMKKAIEAAGSGQLLV 172 Query: 136 LGINIGKNKDTPVEQGKDDYLICMEKIYAY-AGYIAINISSPNTPGLRTL-QYGEALDDL 193 + + D++ + AG + +N S PN R L + + Sbjct: 173 PSFQGSRVDGMDQDDYIADHVTTARLVCETGAGLMEMNTSCPNEGHNRLLCHDPHLVGRI 232 Query: 194 LTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHN-IDGVIATNTTLDRS 252 A+KN+ D P+ VK+A ++ +L + H + G NT + Sbjct: 233 TEAVKNEIGDR--------PLVVKLAYIPNDADLEIMVKETAAHGTVQGFSTINTISAKL 284 Query: 253 LV-QGMKNCDQTG----GLSGRPLQLKSTEIIRRLSL---ELNGRLPIIGVGGIDSVIAA 304 + G + G G+ G ++ +++ RL +L I+GVGG+ Sbjct: 285 VDAHGNQALPGAGRDRSGVCGNAIRGAGLDMVGRLHAIREKLGLDFTIVGVGGVVRPEDY 344 Query: 305 REKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 R AGA+ V +G ++ L ++I + I Sbjct: 345 RAYREAGANAVMSATGAMWN-ANLARDIASSI 375 >UniRef50_Q2GYB9 Putative uncharacterized protein n=1 Tax=Chaetomium globosum RepID=Q2GYB9_CHAGB Length = 351 Score = 87.6 bits (216), Expect = 5e-16, Method: Composition-based stats. Identities = 49/277 (17%), Positives = 91/277 (32%), Gaps = 46/277 (16%) Query: 106 AEGLINRMGFNNLGVDNLVENVKKAHYDGVL----GINIGKNKDTPVEQGKDDYLICMEK 161 IN +G++ L + + ++ + G + ++ + Sbjct: 71 PNASINSLGYSPLTLPIYLGFIQTISDEQPSWSAKGFILSVTGSVEDIAVSYQHIASAAR 130 Query: 162 IYAYAGYIAINISSPNTPGLRTLQY-GEALDDLLTAIKNKQNDLQAMHH---KYVPIAVK 217 + + IN+S PN P + Y GEAL L+ I+ + +P+ +K Sbjct: 131 GVQFPLAMEINLSCPNIPDMPPPAYSGEALTMYLSRIQQVVVETANYDDGNTPRIPVGLK 190 Query: 218 IAPDLSEEELIQVADSLVRHNIDG-------VIATNTTLDRSLVQGMK------------ 258 I P + + +L + G + TNT L+ Sbjct: 191 IPPYTHSTQYHTLIAALEAATLSGGHCPISFITTTNTLGSCLLLDPSPAPAPPDPSSHYP 250 Query: 259 ------NCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLP-------------IIGVGGID 299 GG++G L + + L L+ R P ++GVGG+ Sbjct: 251 GSTTALPGTGIGGMAGAALHPLALGNVATLRRLLDKRWPDEAAGGVNKGRVRLVGVGGVS 310 Query: 300 SVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 AAGA +V + +G KG + E+ + Sbjct: 311 DAAGYLRMRAAGADVVGLATGLGLKGVGVFAEVEGGL 347 >UniRef50_C1SLA1 Dihydroorotate dehydrogenase n=1 Tax=Denitrovibrio acetiphilus DSM 12809 RepID=C1SLA1_9BACT Length = 328 Score = 87.6 bits (216), Expect = 6e-16, Method: Composition-based stats. Identities = 53/307 (17%), Positives = 110/307 (35%), Gaps = 37/307 (12%) Query: 42 VPAKPVNCMGLTFKNPLGLAAGLDKDG-ECIDALGAMGFGSIEIGTVTPR--------PQ 92 + + MGLT KNP+ + + D E I AL G ++ + ++ + Q Sbjct: 1 MSDIRTSFMGLTLKNPVIVGSSTLTDTPEKIKALADNGAAAVVLKSLFEQEVRNLKDSAQ 60 Query: 93 PGNDKPR-LFRLVDAEGLINRMGFNNLGVDNLVENVKKAH--YDGVLGINIGKNKDTPVE 149 N P + + G++ G+ ++ ++ A D + +I K + Sbjct: 61 CCNYHPEAYYYDMSDAGML-------YGISEYLQLIRDAKLATDIPVIASICCEKAAWWK 113 Query: 150 QGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHH 209 + A A + +NI + +L ++ D+ + ++ Sbjct: 114 TYPE------RIANAGADALELNI------NMLSLHGAKSPADIYKDTLQIIHTVKNTTD 161 Query: 210 KYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGR 269 +P +VK++P + + L GV + + + C+ S Sbjct: 162 --LPFSVKLSPYCCS--IPYLVKMLKEEGAKGVTLFSRLFELGINTNTFECEPASYYSSP 217 Query: 270 PLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLI 329 K + +S +++ + I G GI + + I AGA VQ+ S GP +I Sbjct: 218 EETFKVLRWVHLVSEQVD--IEICGNTGIHTSREIIQHIIAGAGAVQMVSSIYKNGPEII 275 Query: 330 KEIVTHI 336 + + + Sbjct: 276 RTCLEEL 282 >UniRef50_A9WGL5 Dihydroorotate dehydrogenase n=3 Tax=Chloroflexus RepID=A9WGL5_CHLAA Length = 278 Score = 87.6 bits (216), Expect = 6e-16, Method: Composition-based stats. Identities = 53/282 (18%), Positives = 99/282 (35%), Gaps = 47/282 (16%) Query: 51 GLTFKNPLGLAAGLDKDGECIDALGAM-------GFGSIEIGTVTPRPQPGNDKPRLFRL 103 GLT +P+ AAG D + + G G+I TVT + G + L Sbjct: 11 GLTIASPVIAAAGSLGDVVGVARWLGLQRADADHGLGAIISSTVTMSGRRGQPQ----LL 66 Query: 104 VDAEGLINRMGFNNLGVDNLVENVKKAH--YDGVLGINIGKNKDTPVEQGKDDYLICMEK 161 G + G +LGV + E + Y + +++ V +D Sbjct: 67 ATPAGTLYHHGGFSLGVRQVRERLAPRWATYHVPILVSLAGPDAAAVASDLND------- 119 Query: 162 IYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPD 221 TPG+ E LTA++ Q +P+ V++ + Sbjct: 120 ----------------TPGIAGF---ELALPALTAVEAAQRVSAVRQATVLPLLVRLPGE 160 Query: 222 LSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCD-QTGGLSGRPLQLKSTEIIR 280 L + + A + + +I + + G L G + + I+ Sbjct: 161 LPDPVAVATACAAAGADALALI-----GGMPGCMPQPSGELVYGRLGGPAIFPIALRIVA 215 Query: 281 RLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFI 322 ++ ++P+IG+GG+ + A+ + AGA V + S + Sbjct: 216 SVA--TTVQVPVIGMGGVTTPAHAQAMLRAGARAVALASALV 255 >UniRef50_B2VR65 Dihydroorotate dehydrogenase n=2 Tax=Pleosporineae RepID=B2VR65_PYRTR Length = 365 Score = 86.8 bits (214), Expect = 1e-15, Method: Composition-based stats. Identities = 51/245 (20%), Positives = 84/245 (34%), Gaps = 41/245 (16%) Query: 129 KAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQY-G 187 K + I++ + + + + + + + A + IN+S PN PG Y Sbjct: 122 KNPTPKPIIISVTGSAEEITQCHRLITALQPKVVMPLA--LEINLSCPNIPGAPPPAYNA 179 Query: 188 EALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRH---------- 237 EAL L+A+ L + + + +K P E+ +A +L Sbjct: 180 EALGVYLSALNEGLASL-SSDADAIAVGIKTPPYTYSEQYDALATALKASLVPKREPGSE 238 Query: 238 -------NIDGVIATNTTLDRSLVQGMKNCD---------------QTGGLSGRPLQLKS 275 I + ATNT L+ GGL+G PL + Sbjct: 239 KIGKQRCPISFITATNTLGSSLLLDPAGPTPQDAAFKHTLLSAAGSGVGGLAGAPLHPLA 298 Query: 276 TEIIRRLSLELNG-----RLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIK 330 + + L + IIG GG++ A GAS V + + F KG + K Sbjct: 299 LGNVYTIKKLLLQNEALLSVQIIGTGGVEDNAGYSRMRAVGASAVGVGTAFGRKGLKVFK 358 Query: 331 EIVTH 335 EI Sbjct: 359 EIGKD 363 >UniRef50_A7NSB8 Dihydroorotate dehydrogenase n=2 Tax=Roseiflexus RepID=A7NSB8_ROSCS Length = 268 Score = 86.8 bits (214), Expect = 1e-15, Method: Composition-based stats. Identities = 51/292 (17%), Positives = 89/292 (30%), Gaps = 36/292 (12%) Query: 46 PVNCMGLTFKNPLGLAAGLDKDG-ECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLV 104 P N GL + P+ AAG G E + G+I G+++ + RL Sbjct: 8 PNNPYGLPLRAPVMTAAGCLGFGVEYERIIPLKHLGAIVTGSISLHGRRALPPLRLVE-- 65 Query: 105 DAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYA 164 G+++ + + G+ ++ A + + D + + + I Sbjct: 66 TPGGVLSVGAWRDPGLTRVLREYAPAWAAWETPVILSVATDHRKVAAALEGVEGIAGIE- 124 Query: 165 YAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSE 224 L G+ + + + + Sbjct: 125 -------------------LTVGDDWSAAVRVVAAVRAVTLLPLLVKL---------PLH 156 Query: 225 EELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSL 284 LI A S+V D V S G LSG ++ E + + Sbjct: 157 ARLIATARSVVDVGADAVTIAA-PPRASAADPHTGELVHGWLSGPAIRPLVLEAVAEVCA 215 Query: 285 ELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 L P++ GGI + AR +AAGA VQ+ S + P I + Sbjct: 216 TLPA--PVVACGGIVTAADARPFLAAGAIAVQVGSALL-ADPWAAVRIAEAL 264 >UniRef50_Q2BA70 Dihydroorotate dehydrogenase n=1 Tax=Bacillus sp. NRRL B-14911 RepID=Q2BA70_9BACI Length = 626 Score = 86.8 bits (214), Expect = 1e-15, Method: Composition-based stats. Identities = 64/343 (18%), Positives = 114/343 (33%), Gaps = 47/343 (13%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALV------RQKVPAKPVNCMGLTFK 55 Y+P + L +L EF + + ++ P + P +G +F+ Sbjct: 6 YHPIFKPILERLPGGAGREFIHKGMNTLSSLPGGRHIIEFLGHMSPAPELQKTMLGYSFQ 65 Query: 56 NPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQ--PGNDKPRLFRLVDAEGLINRM 113 +P+GL+ +D A +GFG +E G V+ Q G + + Sbjct: 66 SPVGLSGKVDPLLSGTKAFTGLGFGFLEAGPVSMEVQLSSG-----TAVKHQDGSISYPV 120 Query: 114 GFNNLGVDNLVENVKKAHYDG-VLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAI- 171 ++GVD + ++K L I I + + ++ + + ++ YA + I Sbjct: 121 PLESIGVDRTISQLEKMKAAHQPLFIRID-SPASSMDLAAAEIIELAGRLCPYASAMIIE 179 Query: 172 NISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVA 231 N G R Q A K P+ + +P ++ +A Sbjct: 180 N-------GWRFKQD--------------HYRKIAGILKGKPVLLGTSPAAFRKQQTVIA 218 Query: 232 DSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLP 291 I G++ QT LS T+ + + P Sbjct: 219 ALADEDLIQGIVL-------DEEASFSGGRQTFPLSAPEAF---TDCLSTIRNAYPAGFP 268 Query: 292 IIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVT 334 I GG+ A AGA L+ + G++ GP L K I Sbjct: 269 AIISGGVLEPEDAISLYTAGADLIMLSGGYVSSGPGLPKRINE 311 >UniRef50_B2B760 Predicted CDS Pa_2_10010 n=1 Tax=Podospora anserina RepID=B2B760_PODAN Length = 339 Score = 84.5 bits (208), Expect = 4e-15, Method: Composition-based stats. Identities = 42/250 (16%), Positives = 89/250 (35%), Gaps = 34/250 (13%) Query: 83 EIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKKAHYD-------GV 135 + P PQ + P + +N +G++ + ++ + K + Sbjct: 69 TSKSTNPTPQEASKAP------AQKASLNTLGYSPYALLQYMQWICKIYTTCSGTQPIKP 122 Query: 136 LGINIGKNKDTPVEQGKDDYLICMEKIYAYAG----YIAINISSPNTPGLRTLQY-GEAL 190 I++ TP E + Y + + Y Y+ IN+S PN P Y +AL Sbjct: 123 FIISV---TGTPTEVS-ECYTCIADYLSEYITAGHIYMEINLSCPNIPNKPPPAYSKDAL 178 Query: 191 DDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHN--IDGVIATNTT 248 + ++ D +P +K P E ++ +L + + TNT Sbjct: 179 VEYFRRLRFAMRDKLRPDLPRLPFGIKTPPYTHASEYNELISALEEEGDQVSFITCTNTL 238 Query: 249 LDRSLVQGMK----NCDQTGGLSGRPLQLKSTEIIRRLSLELNGR-----LPIIGVGGID 299 ++ + GG++G L + + + L+ R + +IG+GG++ Sbjct: 239 GSCLVLSPEGDPVLPGNGIGGMAGAALHPLALGNVATIRRMLDERPSLKHITVIGIGGVE 298 Query: 300 SVIAAREKIA 309 +++ Sbjct: 299 D-EKGYKRMR 307 >UniRef50_B0PC95 Putative uncharacterized protein n=1 Tax=Anaerotruncus colihominis DSM 17241 RepID=B0PC95_9FIRM Length = 799 Score = 84.1 bits (207), Expect = 6e-15, Method: Composition-based stats. Identities = 64/323 (19%), Positives = 122/323 (37%), Gaps = 45/323 (13%) Query: 44 AKPVNCMGLTFKNPLGLAAG-LDKDGECIDALGAMGFGSIEIGTVTPRPQPG-NDKPRLF 101 PV G+TFKNP +A+G K+ + + G+ + I ++ P P N KPR Sbjct: 6 RIPVKVGGVTFKNPFYVASGPTTKNVRQLQRIEETGWAAASIK-LSIDPAPYINRKPRYG 64 Query: 102 RLVDAEGLI----NRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLI 157 + L R+ F G+ L+E+ KK D +L NI ++G ++ Sbjct: 65 LFDETNALAFTAEKRLTFQ-EGL-TLIEDAKKVLSDLILMANI----TYAGDRGAAGWVN 118 Query: 158 CMEKIYAY-AGYIAINISSPNTPGLRTL----------QYGEALDDLLTAIKNKQNDLQA 206 ++ A A I +N+ PN +L Q G +L + ++ Sbjct: 119 MAKQFEAVGADIIELNMCCPNMSYNVSLSSGGAASTSQQTGASLGRQAGVVAEIVRAIKK 178 Query: 207 MHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGG- 265 H +P+ VK+ P+ +VA G A +T +R + + + + G Sbjct: 179 EIH--IPLFVKLTPEGG-----EVAQVAAALYAAGADAVGSTGNRLGLPPI-DLNDPGRA 230 Query: 266 ------------LSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGAS 313 G L+ + + ++ GGI +A E + G + Sbjct: 231 VYHLQDEISMSCYCGSWLKPLAQRDAYEIRKVCGMEPKMMAAGGITDWRSAVEMVLCGGN 290 Query: 314 LVQIYSGFIFKGPPLIKEIVTHI 336 L+ + + + G +++ ++ + Sbjct: 291 LLGVCAETLISGYDIVRPMIRGL 313 >UniRef50_D2S9D7 Dihydroorotate oxidase n=1 Tax=Geodermatophilus obscurus DSM 43160 RepID=D2S9D7_9ACTO Length = 385 Score = 83.4 bits (205), Expect = 1e-14, Method: Composition-based stats. Identities = 59/336 (17%), Positives = 111/336 (33%), Gaps = 42/336 (12%) Query: 39 RQKVPAKPVNCMGLTFKNPLGLAAGLDKDGEC-IDALGAMGFGSIEIGTVTPRPQPGNDK 97 R + + +G P+G+ A + GE + G+ + TV R N + Sbjct: 42 RPRAGDRRWRVLGRDVGFPIGVPACVLNGGEEWVRHFARNGYSVLTYKTVRSRAHEPNAQ 101 Query: 98 P--------------------------RLFRLVDAEGLINRMGFNNLGVDNLVENVKKA- 130 P + +N G +L + + +++++ Sbjct: 102 PNWVFAARQAQSLPPGAAAEVTADPWDWVAPGSPDVSTVNSFGVPSLAPEQWMADLERSL 161 Query: 131 ---HYDGVLGINIGKNKDTPVEQGKDDYLICMEKI-YAYAGYIAINISSPNTPGLRTLQY 186 D +L +++ D DD+ A A + +N+S PNT T Sbjct: 162 AAVDDDQLLLVSVMGEGDGTG--LVDDFAATARLAQEAGASVVELNLSCPNTLSTSTAAG 219 Query: 187 -GEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSL--VRHNIDGVI 243 L A ++ + K++ L L + L + I G+ Sbjct: 220 VKPPLCLDAGATVAVVEGVRRALDDRTGLVAKLSW-LDGARLEALVPRLAPLVDGIAGIN 278 Query: 244 ATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRL---SLELNGRLPIIGVGGIDS 300 + + RS + + GLSG ++ + + RRL ++ +GG+ Sbjct: 279 TLQSRVRRSDGEPTFPGRELAGLSGAAVRDSALDFTRRLVALRDAGGRHFDVLAMGGVTD 338 Query: 301 VIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + A GA VQ SG F P L ++ V + Sbjct: 339 PASFAALFALGADAVQSASG-AFAAPFLARDCVAAL 373 >UniRef50_A6L9F5 Dihydroorotate dehydrogenase family protein n=9 Tax=Bacteria RepID=A6L9F5_PARD8 Length = 325 Score = 83.4 bits (205), Expect = 1e-14, Method: Composition-based stats. Identities = 55/311 (17%), Positives = 106/311 (34%), Gaps = 57/311 (18%) Query: 46 PVNCMGLTFKNPLGL-AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFR-- 102 GLT +NP+ + ++GL E G G+I + + LF Sbjct: 5 KTQYAGLTLRNPIIVGSSGLTNKAERNRDFEKAGAGAIVLKS-------------LFEEQ 51 Query: 103 -------------LVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVE 149 +A I N V++ +E +KK+ + I N Sbjct: 52 IEMQSEALMQDSDYPEAADYIRGYVKANQ-VNDYLELIKKSKELCTIPIIASIN--CYKA 108 Query: 150 QGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDL--QAM 207 D+ +E A + +N+ L + +I++ + + Sbjct: 109 DAWIDFARQIELAG--ADALELNV----------FFMETELTEDFESIRDTYVSIIRKVK 156 Query: 208 HHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLS 267 +P+ +KI + S + + + L + DGV+ N + +S Sbjct: 157 ETVSIPVIMKIGKNYS--NIPSLVNLLKVNGADGVVLFNRFYQPDIDINNMQI-----VS 209 Query: 268 GRPLQLKS-TEIIRRLSLELNGRLPIIGVG---GIDSVIAAREKIAAGASLVQIYSGFIF 323 G S R + ++G++P I + G+ + + AGAS VQ+ S Sbjct: 210 GNVFSNHSDLSDTIRWTAIVSGKIPGISIASSTGVHDWEDVVKCLLAGASAVQMCSAVYT 269 Query: 324 KGPPLIKEIVT 334 G +I +++T Sbjct: 270 HGAEIISQVLT 280 >UniRef50_Q7UHA6 Dihydroorotate dehydrogenase n=1 Tax=Rhodopirellula baltica RepID=Q7UHA6_RHOBA Length = 359 Score = 83.0 bits (204), Expect = 1e-14, Method: Composition-based stats. Identities = 57/311 (18%), Positives = 121/311 (38%), Gaps = 44/311 (14%) Query: 42 VPAKPVNCMGLTFKNPLGLAA-GLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRL 100 + +G+ ++P+ + A L E + + A G G+I + ++ + Q + R+ Sbjct: 14 PSELITSYLGMQLESPVVMGACPLTTQSEAVRQIVAAGAGAIVLPSI-LQEQVMH---RM 69 Query: 101 FRLVDAEGLINRMGFN------NLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDD 154 + D G I R G+ N G + + + + + + N + + + Sbjct: 70 IKATDPFGAIERSGYQPQQDKYNGGTEAYLRTISRLKGICSVPVIASMNGSSAGQWLQ-- 127 Query: 155 YLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPI 214 Y ME A A + N+ E +D+ + + ++ + +P+ Sbjct: 128 YAKEME--SAGADALEFNL------QQAVFDSKETSNDIEARMCDLIRQVRELVV--IPV 177 Query: 215 AVKIAPDLSEEELIQVADSLVRHNIDGVIAT------NTTLDR---SLVQGMKNCDQTGG 265 A KI+ + L +A L + + G++ + + DR ++ + + GG Sbjct: 178 AAKISQRYT--NLSSMATQLRQVGVAGLVLFTHMPQWDVSTDRMHWTINWELSPTNSIGG 235 Query: 266 LSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKG 325 + E I R + + + I GG+ + A + + AGA +V + S +G Sbjct: 236 I---------LEGIVR-ARAGDQAISIAASGGVSNSEDAIKAMIAGADVVMVTSAVYRRG 285 Query: 326 PPLIKEIVTHI 336 P I++IV I Sbjct: 286 PDAIRDIVDGI 296 >UniRef50_A7EUV5 Putative uncharacterized protein n=2 Tax=Sclerotiniaceae RepID=A7EUV5_SCLS1 Length = 346 Score = 82.2 bits (202), Expect = 3e-14, Method: Composition-based stats. Identities = 45/265 (16%), Positives = 99/265 (37%), Gaps = 38/265 (14%) Query: 103 LVDAEGLINRMGFNNLGVDNLVENVKKAHYD--------GVLGINIGKNKDTPVEQGKDD 154 + +N +G++ + +D+ ++ V + D I++ + E+ + Sbjct: 83 IPGETNSLNTLGYSPISLDSYLDIVLELAKDESFQLLTPKPWIISVTGSA----EEVAEC 138 Query: 155 YLICMEK--IYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYV 212 Y + + + IN+S PN G Y E + + + ++A + Sbjct: 139 YRHVLRQHGKANLNLMMEINLSCPNIVGKPPPAYNE---EAMASYIKVIRGVKAEAPNSI 195 Query: 213 PIAVKIAPDLSEEELIQVADSLVRH-------NIDGVIATNTTLDRSLVQGMKN------ 259 + +K P E+ + +L I + ATNT ++ N Sbjct: 196 HVGIKTPPYTYSEQFRNLISALESGASLDGGIPISFITATNTLGSCLVIDESGNPVLGSS 255 Query: 260 -CDQTGGLSGRPLQLKSTEIIRRLSLELNGR-------LPIIGVGGIDSVIAAREKIAAG 311 + GG++G L + +R + L+ + IIGVGG+ + G Sbjct: 256 SGEGIGGMAGDALHPIALGNVRTIRKMLDASPIKGVRNMEIIGVGGVKDSPSFTRMRIVG 315 Query: 312 ASLVQIYSGFIFKGPPLIKEIVTHI 336 AS+V + + +G + ++I++ + Sbjct: 316 ASIVGVGTALGREGVGIFEQILSGL 340 Searching..................................................done Results from round 3 Score E Sequences producing significant alignments: (bits) Value Sequences used in model and found again: UniRef50_B6J754 Dihydroorotate dehydrogenase n=26 Tax=Proteobact... 385 e-105 UniRef50_B1KDM8 Dihydroorotate dehydrogenase n=26 Tax=Gammaprote... 363 7e-99 UniRef50_C0Z506 Dihydroorotate dehydrogenase n=8 Tax=Bacteria Re... 361 2e-98 UniRef50_B2UNA2 Dihydroorotate dehydrogenase n=8 Tax=Bacteria Re... 347 3e-94 UniRef50_Q2Y5H8 Dihydroorotate dehydrogenase n=195 Tax=cellular ... 346 6e-94 UniRef50_B0W4C3 Dihydroorotate dehydrogenase, mitochondrial n=2 ... 345 1e-93 UniRef50_P32748 Dihydroorotate dehydrogenase, mitochondrial n=14... 345 2e-93 UniRef50_A1WJ81 Dihydroorotate dehydrogenase n=250 Tax=Bacteria ... 345 2e-93 UniRef50_Q7PYN9 AGAP002037-PA (Fragment) n=10 Tax=cellular organ... 344 3e-93 UniRef50_A5EV79 Dihydroorotate dehydrogenase n=3 Tax=Gammaproteo... 341 2e-92 UniRef50_A6H0L5 Dihydroorotate dehydrogenase n=28 Tax=Bacteria R... 340 6e-92 UniRef50_A1WTJ3 Dihydroorotate dehydrogenase n=1 Tax=Halorhodosp... 339 7e-92 UniRef50_Q5PR57 Dihydroorotate dehydrogenase n=20 Tax=cellular o... 339 8e-92 UniRef50_A9WDI1 Dihydroorotate dehydrogenase n=13 Tax=Bacteria R... 339 8e-92 UniRef50_Q02127 Dihydroorotate dehydrogenase, mitochondrial n=39... 338 2e-91 UniRef50_Q3IU78 Dihydroorotate dehydrogenase n=13 Tax=cellular o... 337 3e-91 UniRef50_A9CK85 Dihydroorotate dehydrogenase n=16 Tax=Alphaprote... 337 3e-91 UniRef50_P57443 Dihydroorotate dehydrogenase n=2 Tax=Proteobacte... 336 7e-91 UniRef50_D2S350 Dihydroorotate dehydrogenase n=2 Tax=Halobacteri... 335 1e-90 UniRef50_Q2YWG7 Dihydroorotate dehydrogenase n=56 Tax=Staphyloco... 335 2e-90 UniRef50_C2QE06 Dihydroorotate dehydrogenase n=3 Tax=Bacillus ce... 335 2e-90 UniRef50_C9YAQ9 Dihydroorotate dehydrogenase n=2 Tax=cellular or... 334 3e-90 UniRef50_A7NLW9 Dihydroorotate dehydrogenase n=18 Tax=Bacteria R... 331 2e-89 UniRef50_Q75XR0 Dihydroorotate dehydrogenase n=3 Tax=Eukaryota R... 328 2e-88 UniRef50_Q1V0W4 Dihydroorotate dehydrogenase n=5 Tax=Bacteria Re... 327 4e-88 UniRef50_Q9RX14 Dihydroorotate dehydrogenase n=4 Tax=Bacteria Re... 326 5e-88 UniRef50_Q2RX27 Dihydroorotate dehydrogenase n=14 Tax=cellular o... 325 2e-87 UniRef50_A5UX75 Dihydroorotate dehydrogenase n=1 Tax=Roseiflexus... 325 2e-87 UniRef50_Q5HL43 Dihydroorotate dehydrogenase n=8 Tax=Staphylococ... 325 2e-87 UniRef50_B6BWI2 Dihydroorotate oxidase n=1 Tax=beta proteobacter... 324 2e-87 UniRef50_B3CMR9 Dihydroorotate dehydrogenase n=10 Tax=Rickettsia... 324 3e-87 UniRef50_Q0J918 Os04g0676300 protein n=1 Tax=Oryza sativa Japoni... 322 1e-86 UniRef50_A8WW30 C. briggsae CBR-DHOD-1 protein n=3 Tax=Caenorhab... 321 2e-86 UniRef50_Q056I9 Dihydroorotate dehydrogenase n=6 Tax=Leptospira ... 321 2e-86 UniRef50_C6NV76 Dihydroorotate dehydrogenase n=1 Tax=Acidithioba... 321 3e-86 UniRef50_B0CUF5 Predicted protein n=4 Tax=Dikarya RepID=B0CUF5_L... 320 4e-86 UniRef50_B3DX48 Dihydroorotate dehydrogenase n=1 Tax=Methylacidi... 320 4e-86 UniRef50_B0MVX7 Putative uncharacterized protein n=1 Tax=Alistip... 320 5e-86 UniRef50_B6R4R9 Dihydroorotate oxidase n=1 Tax=Pseudovibrio sp. ... 320 5e-86 UniRef50_A5EA61 Dihydroorotate dehydrogenase n=122 Tax=cellular ... 318 2e-85 UniRef50_Q1GGD3 Dihydroorotate oxidase A n=18 Tax=Alphaproteobac... 316 8e-85 UniRef50_B9L4A8 Dihydroorotate oxidase n=2 Tax=Thermomicrobia (c... 315 1e-84 UniRef50_Q83GM4 Dihydroorotate oxidase n=2 Tax=Tropheryma whippl... 315 2e-84 UniRef50_B7G8S8 Predicted protein n=2 Tax=Bacillariophyta RepID=... 314 2e-84 UniRef50_Q47RF2 Dihydroorotate dehydrogenase n=52 Tax=Bacteria R... 314 3e-84 UniRef50_Q30R79 Dihydroorotate dehydrogenase n=10 Tax=Campylobac... 314 3e-84 UniRef50_B1ZSY3 Dihydroorotate oxidase n=3 Tax=Verrucomicrobia R... 313 6e-84 UniRef50_Q0GF37 Dihydroorotate dehydrogenase n=2 Tax=Ustilago ma... 312 1e-83 UniRef50_Q75CE1 Dihydroorotate dehydrogenase, mitochondrial n=9 ... 310 5e-83 UniRef50_B9KHW9 Dihydroorotate dehydrogenase (PyrD) n=10 Tax=Ric... 310 5e-83 UniRef50_C3XDT6 Dihydroorotate dehydrogenase n=4 Tax=Helicobacte... 309 9e-83 UniRef50_B6KTR1 Dihydroorotate dehydrogenase n=4 Tax=Toxoplasma ... 309 1e-82 UniRef50_B4UG99 Dihydroorotate dehydrogenase n=23 Tax=Bacteria R... 309 1e-82 UniRef50_A8Q682 Putative uncharacterized protein n=1 Tax=Malasse... 308 1e-82 UniRef50_A2VBP6 Dihydroorotate dehydrogenase, mitochondrial n=1 ... 308 2e-82 UniRef50_B3L830 Dihydroorotate dehydrogenase, putative n=1 Tax=P... 308 3e-82 UniRef50_P32747 Dihydroorotate dehydrogenase, mitochondrial n=2 ... 307 3e-82 UniRef50_C6XQ80 Dihydroorotate dehydrogenase n=1 Tax=Hirschia ba... 306 6e-82 UniRef50_C4QIG2 Dihydroorotate dehydrogenase n=3 Tax=Schistosoma... 304 3e-81 UniRef50_B5Z6I2 Dihydroorotate dehydrogenase n=28 Tax=Campylobac... 304 3e-81 UniRef50_B7JXU8 Dihydroorotate dehydrogenase n=8 Tax=Cyanobacter... 303 4e-81 UniRef50_P74782 Dihydroorotate dehydrogenase n=24 Tax=Bacteria R... 303 4e-81 UniRef50_Q2GEM2 Dihydroorotate dehydrogenase n=2 Tax=Neoricketts... 303 4e-81 UniRef50_D1SB76 Dihydroorotate dehydrogenase n=2 Tax=Micromonosp... 303 5e-81 UniRef50_C1EIH8 Dihydropryrimidine dehydrogenase n=1 Tax=Micromo... 303 7e-81 UniRef50_Q5UF20 Predicted dihydroorotate dehydrogenase n=1 Tax=u... 302 9e-81 UniRef50_D1B1W1 Dihydroorotate dehydrogenase n=2 Tax=Campylobact... 302 1e-80 UniRef50_D2PV93 Dihydroorotate dehydrogenase n=1 Tax=Kribbella f... 302 1e-80 UniRef50_A5U4G5 Dihydroorotate dehydrogenase n=31 Tax=Corynebact... 301 3e-80 UniRef50_Q8D370 Dihydroorotate dehydrogenase n=46 Tax=Gammaprote... 299 7e-80 UniRef50_A7AUQ8 Dihydroorotate dehydrogenase n=2 Tax=Piroplasmid... 299 1e-79 UniRef50_A9HBE5 Dihydroorotate oxidase n=10 Tax=Acetobacteraceae... 298 1e-79 UniRef50_D2UZD6 Predicted protein n=1 Tax=Naegleria gruberi RepI... 298 3e-79 UniRef50_Q827Q6 Dihydroorotate dehydrogenase n=12 Tax=Actinomyce... 296 6e-79 UniRef50_Q2S001 Dihydroorotate oxidase n=2 Tax=Rhodothermaceae R... 294 3e-78 UniRef50_Q7RLG4 Dihydroorotate dehydrogenase, putative n=2 Tax=P... 294 3e-78 UniRef50_A5K1N1 Dihydroorotate dehydrogenase, mitochondrial, put... 293 6e-78 UniRef50_B9L9P6 Dihydroorotate dehydrogenase n=7 Tax=Epsilonprot... 293 8e-78 UniRef50_Q5KK62 Dihydroorotate dehydrogenase, mitochondrial, put... 291 3e-77 UniRef50_Q08210 Dihydroorotate dehydrogenase homolog, mitochondr... 289 8e-77 UniRef50_Q6SZS6 Dihydroorotate dehydrogenase, mitochondrial n=10... 289 9e-77 UniRef50_C0W1V7 Possible dihydroorotate oxidase n=1 Tax=Actinomy... 285 2e-75 UniRef50_A9F3A8 PyrD protein n=1 Tax=Sorangium cellulosum 'So ce... 284 4e-75 UniRef50_C6IFT5 Dihydroorotate dehydrogenase 2 n=7 Tax=Bacteroid... 283 8e-75 UniRef50_Q7U3U2 Dihydroorotate dehydrogenase n=30 Tax=cellular o... 280 4e-74 UniRef50_C2BWU0 Possible dihydroorotate oxidase n=3 Tax=Mobilunc... 280 4e-74 UniRef50_D1CE91 Dihydroorotate dehydrogenase n=1 Tax=Thermobacul... 276 6e-73 UniRef50_Q6MPX3 PyrD protein n=1 Tax=Bdellovibrio bacteriovorus ... 275 2e-72 UniRef50_B5CXJ8 Putative uncharacterized protein n=3 Tax=Bactero... 274 3e-72 UniRef50_D0IRU1 Dihydroorotate dehydrogenase n=1 Tax=Helicobacte... 274 4e-72 UniRef50_C7NF21 Dihydroorotate oxidase A n=1 Tax=Kytococcus sede... 273 5e-72 UniRef50_B2B417 Predicted CDS Pa_6_7920 n=3 Tax=Sordariomycetes ... 271 2e-71 UniRef50_C5K5A0 Dihydroorotate dehydrogenase, putative n=2 Tax=P... 271 2e-71 UniRef50_D1ZM19 Whole genome shotgun sequence assembly, scaffold... 271 3e-71 UniRef50_A7BDH3 Putative uncharacterized protein n=1 Tax=Actinom... 265 1e-69 UniRef50_Q2H299 Putative uncharacterized protein n=3 Tax=cellula... 264 3e-69 UniRef50_A3ZNL9 Dihydroorotate dehydrogenase n=2 Tax=Planctomyce... 264 4e-69 UniRef50_UPI00016B255A dihydroorotate dehydrogenase 2 n=4 Tax=ca... 258 2e-67 UniRef50_C6A9A6 Dihydroorotate dehydrogenase 2 n=20 Tax=Bifidoba... 250 5e-65 UniRef50_A2QCB1 Catalytic activity: n=26 Tax=Leotiomyceta RepID=... 245 2e-63 UniRef50_B2V726 Dihydroorotate dehydrogenase n=2 Tax=Aquificales... 237 4e-61 UniRef50_C0QU30 Dihydroorotate dehydrogenase, catalytic subunit ... 237 6e-61 UniRef50_O27281 Dihydroorotate dehydrogenase n=20 Tax=Euryarchae... 231 3e-59 UniRef50_B0TGQ8 Dihydroorotate dehydrogenase n=32 Tax=Bacteria R... 229 9e-59 UniRef50_A4IM35 Dihydroorotate dehydrogenase n=348 Tax=Bacteria ... 227 3e-58 UniRef50_Q4N5X1 Dihydroorotate dehydrogenase, putative n=1 Tax=T... 227 3e-58 UniRef50_Q2NEG1 PyrD n=1 Tax=Methanosphaera stadtmanae DSM 3091 ... 225 2e-57 UniRef50_A6L5H1 Dihydroorotate dehydrogenase n=7 Tax=Bacteroidal... 225 2e-57 UniRef50_Q979G6 Dihydroorotate dehydrogenase n=4 Tax=Thermoplasm... 224 3e-57 UniRef50_A9A3M4 Dihydroorotate dehydrogenase family protein n=2 ... 224 4e-57 UniRef50_B5YFH3 Dihydroorotate dehydrogenase n=2 Tax=Dictyoglomu... 222 1e-56 UniRef50_UPI00016B240E dihydroorotate dehydrogenase 2 n=1 Tax=ca... 222 1e-56 UniRef50_Q3AC05 Dihydroorotate dehydrogenase n=1 Tax=Carboxydoth... 222 2e-56 UniRef50_C9KKE5 Dihydroorotate oxidase n=6 Tax=Bacteria RepID=C9... 220 4e-56 UniRef50_A9BJH4 Dihydroorotate dehydrogenase n=45 Tax=Bacteria R... 220 5e-56 UniRef50_Q1G992 Dihydroorotate dehydrogenase n=3 Tax=Lactobacill... 219 8e-56 UniRef50_C0QYH6 Dihydroorotate dehydrogenase n=2 Tax=Brachyspira... 218 2e-55 UniRef50_Q0W8E1 Dihydroorotate dehydrogenase n=18 Tax=Euryarchae... 217 4e-55 UniRef50_B5YJH1 Dihydroorotate dehydrogenase n=24 Tax=Bacteria R... 217 4e-55 UniRef50_C8WHP0 Dihydroorotate dehydrogenase family protein n=3 ... 215 2e-54 UniRef50_Q3J7C7 Dihydroorotate oxidase B, catalytic subunit n=10... 215 2e-54 UniRef50_A6G037 Dihydroorotate dehydrogenase 1 n=1 Tax=Plesiocys... 214 5e-54 UniRef50_D1YYV3 Dihydroorotate dehydrogenase n=1 Tax=Methanocell... 212 1e-53 UniRef50_Q1MQG1 Dihydroorotate dehydrogenase n=2 Tax=Deltaproteo... 211 2e-53 UniRef50_D1JFH0 Dihydroorotate dehydrogenase electron transfer s... 210 4e-53 UniRef50_C8W700 Dihydroorotate dehydrogenase family protein n=2 ... 210 5e-53 UniRef50_Q01YA2 Dihydroorotate dehydrogenase n=5 Tax=Bacteria Re... 210 5e-53 UniRef50_P28272 Dihydroorotate dehydrogenase n=168 Tax=cellular ... 210 7e-53 UniRef50_C4F860 Putative uncharacterized protein n=2 Tax=Collins... 209 8e-53 UniRef50_C6SRR7 Putative dihydroorotate dehydrogenase dihydrooro... 209 9e-53 UniRef50_A4ECL7 Putative uncharacterized protein n=1 Tax=Collins... 208 2e-52 UniRef50_B2WMQ8 Dihydroorotate dehydrogenase, mitochondrial n=3 ... 208 2e-52 UniRef50_C1TMB2 Dihydroorotate dehydrogenase family protein n=1 ... 208 3e-52 UniRef50_C6A1L2 Dihydroorotate dehydrogenase family protein n=1 ... 207 4e-52 UniRef50_O29513 Dihydroorotate dehydrogenase n=3 Tax=Archaeoglob... 207 5e-52 UniRef50_Q2IVE7 Dihydroorotate oxidase B, catalytic subunit n=1 ... 207 6e-52 UniRef50_B1MZ73 Dihydroorotate dehydrogenase B, catalytic subuni... 205 2e-51 UniRef50_C9RJ75 Dihydroorotate oxidase n=1 Tax=Fibrobacter succi... 204 3e-51 UniRef50_Q1Q4L5 Similar to dihydroorotate oxidase (Dihydroorotat... 204 4e-51 UniRef50_C1A4J6 Dihydroorotate dehydrogenase n=1 Tax=Gemmatimona... 203 6e-51 UniRef50_B1GYY3 Dihydroorotate dehydrogenase n=1 Tax=uncultured ... 203 9e-51 UniRef50_B8D3W9 Dihydroorotate dehydrogenase, PyrD n=1 Tax=Desul... 201 2e-50 UniRef50_C2D6B3 Dihydroorotate oxidase n=1 Tax=Atopobium vaginae... 200 7e-50 UniRef50_C1EGR6 Predicted protein n=8 Tax=Viridiplantae RepID=C1... 200 7e-50 UniRef50_Q3B2I1 Dihydroorotate oxidase B, catalytic subunit n=12... 199 9e-50 UniRef50_A9D5Y9 Dihydroorotate dehydrogenase n=1 Tax=Shewanella ... 199 1e-49 UniRef50_B1I4M6 Dihydroorotate dehydrogenase n=73 Tax=Bacteria R... 199 1e-49 UniRef50_Q0B324 Dihydroorotate oxidase B, catalytic subunit n=8 ... 199 1e-49 UniRef50_Q00YC9 Dihydroorotate dehydrogenase (ISS) (Fragment) n=... 197 4e-49 UniRef50_Q9LVI9 Senescencs-related protein; dihydroorotate dehyd... 197 6e-49 UniRef50_A0NIQ6 Dihydroorotate dehydrogenase A n=7 Tax=Lactobaci... 197 6e-49 UniRef50_B7RZ94 Dihydroorotate dehydrogenase family protein n=3 ... 196 1e-48 UniRef50_A1RZC9 Dihydroorotate oxidase B, catalytic subunit n=2 ... 195 1e-48 UniRef50_A5VL42 Dihydroorotate oxidase B, catalytic subunit n=14... 195 2e-48 UniRef50_Q12882 Dihydropyrimidine dehydrogenase [NADP+] n=94 Tax... 195 2e-48 UniRef50_D2RBF2 Dihydroorotate dehydrogenase 1B n=21 Tax=Bifidob... 194 3e-48 UniRef50_A9BIU8 Dihydroorotate dehydrogenase family protein n=10... 194 4e-48 UniRef50_C5R8W8 Dihydroorotate dehydrogenase B, catalytic subuni... 193 9e-48 UniRef50_A8MJK5 Dihydroorotate dehydrogenase family protein n=1 ... 192 1e-47 UniRef50_C0WNB5 Dihydroorotate dehydrogenase n=3 Tax=Lactobacill... 192 1e-47 UniRef50_B9TAL5 Dihydroorotate dehydrogenase, putative n=1 Tax=R... 192 1e-47 UniRef50_B5YA20 Dihydroorotate dehydrogenase (Dihydroorotate oxi... 192 2e-47 UniRef50_C9M6H2 Dihydroorotate oxidase n=2 Tax=Synergistaceae Re... 191 3e-47 UniRef50_P25889 Uncharacterized protein yeiA n=116 Tax=Bacteria ... 190 4e-47 UniRef50_D0JBI0 Dihydroorotate dehydrogenase n=2 Tax=Blattabacte... 190 6e-47 UniRef50_A5IK84 Dihydroorotate dehydrogenase n=10 Tax=Thermotoga... 188 2e-46 UniRef50_Q8TXU6 Dihydroorotate dehydrogenase n=1 Tax=Methanopyru... 188 3e-46 UniRef50_A0LUF8 Dihydroorotate oxidase B, catalytic subunit n=6 ... 187 5e-46 UniRef50_A3DM44 Dihydroorotate oxidase B, catalytic subunit n=1 ... 186 9e-46 UniRef50_C6Q0J2 Dihydroorotate dehydrogenase family protein n=1 ... 185 2e-45 UniRef50_B0VIM3 Dihydroorotate dehydrogenase, catalytic subunit ... 185 2e-45 UniRef50_A6DND8 Dihydroorotate dehydrogenase n=1 Tax=Lentisphaer... 185 2e-45 UniRef50_C5CHS6 Dihydroorotate dehydrogenase family protein n=1 ... 184 4e-45 UniRef50_O08358 Dihydroorotate dehydrogenase n=12 Tax=Sulfolobac... 183 8e-45 UniRef50_Q9YFI6 Dihydroorotate dehydrogenase n=3 Tax=Desulfuroco... 183 1e-44 UniRef50_Q73P17 Dihydroorotate dehydrogenase/oxidoreductase, FAD... 182 2e-44 UniRef50_D2QWH7 Dihydroorotate dehydrogenase family protein n=6 ... 182 2e-44 UniRef50_A6LJ97 Dihydroorotate dehydrogenase family protein n=2 ... 181 3e-44 UniRef50_A3U0T3 Probable dihydroorotate dehydrogenase, catalytic... 181 4e-44 UniRef50_Q01P61 Dihydropyrimidine dehydrogenase (NADP+) / dihydr... 180 7e-44 UniRef50_D0U5Z4 Dihydroorotate dehydrogenase subfamily 1 family ... 179 1e-43 UniRef50_UPI0001C31DA9 dihydroorotate dehydrogenase family prote... 179 1e-43 UniRef50_A9GKC4 Dihydropyrimidine dehydrogenase n=5 Tax=Bacteria... 179 1e-43 UniRef50_A0CDX9 Chromosome undetermined scaffold_17, whole genom... 179 1e-43 UniRef50_B3E2T4 Dihydroorotate dehydrogenase family protein n=1 ... 179 2e-43 UniRef50_A0Z3E6 Dihydroorotate dehydrogenase/oxidoreductase, FAD... 176 1e-42 UniRef50_C7M0V6 Dihydroorotate dehydrogenase family protein n=1 ... 175 1e-42 UniRef50_B0EHW2 Dihydropyrimidine dehydrogenase, putative n=2 Ta... 175 3e-42 UniRef50_B0PGY1 Putative uncharacterized protein n=1 Tax=Anaerot... 174 4e-42 UniRef50_B7G610 Predicted protein n=2 Tax=Bacillariophyta RepID=... 174 5e-42 UniRef50_A8MCA1 Dihydroorotate oxidase n=1 Tax=Caldivirga maquil... 174 6e-42 UniRef50_C4IB41 Dihydroorotate dehydrogenase family protein n=4 ... 173 8e-42 UniRef50_C0ZGG5 Hypothetical membrane protein n=1 Tax=Brevibacil... 172 1e-41 UniRef50_C9XJU2 Dihydroorotate dehydrogenase, catalytic subunit ... 172 2e-41 UniRef50_UPI0001791DE1 PREDICTED: similar to dihydropyrimidine d... 172 2e-41 UniRef50_UPI0001968A99 hypothetical protein BACCELL_01888 n=1 Ta... 171 3e-41 UniRef50_Q1AVZ1 Dihydroorotate oxidase B, catalytic subunit n=1 ... 171 3e-41 UniRef50_B8D2W4 Dihydroorotate dehydrogenase family protein n=1 ... 168 3e-40 UniRef50_A4FBL7 Dihydroorotate dehydrogenase n=1 Tax=Saccharopol... 167 7e-40 UniRef50_Q7N0H1 Similar to dihydroorotate dehydrogenase PyrD n=1... 166 1e-39 UniRef50_Q972L2 350aa long hypothetical dihydroorotate dehydroge... 165 1e-39 UniRef50_D1B5N0 Dihydroorotate dehydrogenase family protein n=1 ... 165 2e-39 UniRef50_A8F8E8 Dihydroorotate dehydrogenase n=1 Tax=Thermotoga ... 164 3e-39 UniRef50_A6BB63 Dihydroorotate dehydrogenase n=1 Tax=Vibrio para... 163 6e-39 UniRef50_Q0CXV7 Putative uncharacterized protein n=1 Tax=Aspergi... 162 1e-38 UniRef50_Q23YG3 Dihydroorotate dehydrogenase family protein n=1 ... 162 1e-38 UniRef50_A2ELU8 Dihydroorotate dehydrogenase family protein n=3 ... 162 1e-38 UniRef50_A3DL41 Dihydroorotate dehydrogenase family protein n=1 ... 160 4e-38 UniRef50_C1TLU5 Dihydroorotate dehydrogenase family protein n=1 ... 159 1e-37 UniRef50_P07670 Dihydroorotate dehydrogenase n=1 Tax=Dictyosteli... 158 2e-37 UniRef50_Q8YVR2 Alr1912 protein n=15 Tax=Bacteria RepID=Q8YVR2_A... 157 6e-37 UniRef50_A2EKA7 Dihydroorotate dehydrogenase family protein n=3 ... 156 8e-37 UniRef50_A0ADR6 Putative hihydroorotate dehydrogenase n=1 Tax=St... 155 2e-36 UniRef50_Q47C62 Dihydroorotate dehydrogenase n=3 Tax=Proteobacte... 154 4e-36 UniRef50_B8E1W3 Dihydroorotate dehydrogenase n=3 Tax=Bacteria Re... 153 1e-35 UniRef50_B1ZTF1 Dihydroorotate dehydrogenase n=1 Tax=Opitutus te... 152 3e-35 UniRef50_A3ETM0 Dihydroorotate dehydrogenase n=3 Tax=Leptospiril... 150 6e-35 UniRef50_B8EIT2 Dihydroorotate dehydrogenase n=2 Tax=Alphaproteo... 149 1e-34 UniRef50_C1SLA1 Dihydroorotate dehydrogenase n=1 Tax=Denitrovibr... 149 2e-34 UniRef50_B9UIZ1 Putative dehydrogenase n=1 Tax=Streptomyces flav... 148 2e-34 UniRef50_A6CFX5 Putative uncharacterized protein n=1 Tax=Plancto... 148 3e-34 UniRef50_C3KS38 Putative hihydroorotate dehydrogenase n=2 Tax=Cl... 148 4e-34 UniRef50_C5S5E1 Dihydroorotate dehydrogenase n=1 Tax=Allochromat... 147 4e-34 UniRef50_C3PUX9 Dihydroorotate dehydrogenase 2 n=29 Tax=Bacteroi... 147 7e-34 UniRef50_A6L9F5 Dihydroorotate dehydrogenase family protein n=9 ... 144 3e-33 UniRef50_A4WLH6 Dihydroorotate dehydrogenase n=5 Tax=Thermoprote... 144 3e-33 UniRef50_A1UMT4 Dihydroorotate dehydrogenase n=9 Tax=Actinomycet... 144 5e-33 UniRef50_A8PKY4 Dihydroorotate dehydrogenase (Dihydroorotate oxi... 143 1e-32 UniRef50_Q2W4R2 Dihydroorotate dehydrogenase n=2 Tax=Magnetospir... 143 1e-32 UniRef50_B0P959 Putative uncharacterized protein n=1 Tax=Anaerot... 142 2e-32 UniRef50_B3E0W2 Dihydroorotate dehydrogenase n=1 Tax=Methylacidi... 139 1e-31 UniRef50_B8G4M8 Dihydroorotate dehydrogenase n=11 Tax=Bacteria R... 138 2e-31 UniRef50_Q7UHA6 Dihydroorotate dehydrogenase n=1 Tax=Rhodopirell... 138 3e-31 UniRef50_Q4DGY9 Dihydroorotate dehydrogenase, putative n=1 Tax=T... 137 5e-31 UniRef50_A5AEM5 Putative uncharacterized protein n=1 Tax=Vitis v... 136 1e-30 UniRef50_A0Q6L0 TRNA-dihydrouridine synthase n=19 Tax=Francisell... 136 1e-30 UniRef50_B3EIF4 Dihydroorotate dehydrogenase n=3 Tax=Chlorobium/... 134 5e-30 UniRef50_A8ZNQ0 Dihydroorotate oxidase, putative n=4 Tax=Cyanoba... 134 5e-30 UniRef50_B0VG14 Putative dihydropyrimidine dehydrogenase [NADP+]... 134 5e-30 UniRef50_C1DSD9 Dihydroorotate dehydrogenase n=1 Tax=Azotobacter... 133 6e-30 UniRef50_UPI0001C36786 dihydroorotate dehydrogenase family prote... 133 9e-30 UniRef50_C7JI08 Dihydroorotate dehydrogenase n=8 Tax=Acetobacter... 133 1e-29 UniRef50_D2M1S9 Dihydroorotate dehydrogenase n=1 Tax=Bacillus ce... 132 1e-29 UniRef50_Q871G0 Related to dihydroorotate dehydrogenase a n=3 Ta... 132 2e-29 UniRef50_D2Q7Y3 Pyr Dihydroorotate dehydrogenase n=16 Tax=Bacter... 132 2e-29 UniRef50_Q7US31 Putative uncharacterized protein n=1 Tax=Rhodopi... 132 2e-29 UniRef50_Q2BA70 Dihydroorotate dehydrogenase n=1 Tax=Bacillus sp... 131 3e-29 UniRef50_B7K1Y7 Dihydroorotate dehydrogenase n=10 Tax=Cyanobacte... 130 5e-29 UniRef50_B0MVY1 Putative uncharacterized protein n=1 Tax=Alistip... 130 7e-29 UniRef50_Q3A324 Dihydrouridine synthase n=10 Tax=Desulfuromonada... 130 7e-29 Sequences not found previously or not previously below threshold: >UniRef50_B6J754 Dihydroorotate dehydrogenase n=26 Tax=Proteobacteria RepID=PYRD_COXB1 Length = 347 Score = 385 bits (989), Expect = e-105, Method: Composition-based stats. Identities = 164/336 (48%), Positives = 223/336 (66%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 M Y ++R LF+L+PE AH T L+ Q+ P KP G+ F NP+GL Sbjct: 1 MIYRYLRPWLFKLEPETAHALTLNCLKWFYCYWLINRRLQRFPQKPTVVFGIEFPNPVGL 60 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAGLDK+GE +D L +GFG IE+G VTP+PQPGN KPR+FRL A LINRMGFNNLGV Sbjct: 61 AAGLDKNGEYMDELLGLGFGFIEVGAVTPKPQPGNSKPRIFRLPQARALINRMGFNNLGV 120 Query: 121 DNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPG 180 D LVE +K+ G++G+NIGKN TP+E+ +DY C EK+Y+Y Y+ INISSPNTP Sbjct: 121 DYLVEQLKRRKVKGIVGVNIGKNLTTPLEKAHEDYQNCFEKLYSYVDYVTINISSPNTPE 180 Query: 181 LRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNID 240 LR LQ L DLLT +K Q L+ +HK VP+ +KIAPDL+ EE+ +A ++H I+ Sbjct: 181 LRQLQSERYLADLLTRLKEDQRRLEDQYHKRVPLFLKIAPDLTPEEIQTIATLALQHRIE 240 Query: 241 GVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDS 300 G++ATNT+ R + + N ++ GGLSG+PL + +++++L L +PI+ VGGI S Sbjct: 241 GIVATNTSCSRQGTEKLPNANEAGGLSGKPLFPMTLQVVKQLHSFLGDEIPIVAVGGIFS 300 Query: 301 VIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 A+ I AGA LVQ+Y+G I++GP L+K IV + Sbjct: 301 GENAQTLINAGARLVQLYTGLIYEGPELVKNIVEFL 336 >UniRef50_B1KDM8 Dihydroorotate dehydrogenase n=26 Tax=Gammaproteobacteria RepID=PYRD_SHEWM Length = 340 Score = 363 bits (931), Expect = 7e-99, Method: Composition-based stats. Identities = 213/335 (63%), Positives = 263/335 (78%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 M+Y +K +FQ+DPE+AH F L TP + QK+ PV MG+TF NP+GL Sbjct: 1 MFYKLAQKVMFQMDPEKAHHFALNSLMATANTPLDCFYAQKIAPSPVEFMGVTFPNPVGL 60 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAG+DKDGECID AMGFG IE+GTVTPRPQPGND PRLFRL A+G+INRMGFNN GV Sbjct: 61 AAGMDKDGECIDGFHAMGFGHIEVGTVTPRPQPGNDLPRLFRLKPAKGIINRMGFNNKGV 120 Query: 121 DNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPG 180 DNL+ N+K A ++G+NIGKNKDTPVEQGKDDYLICM+K+Y YA YIA+NISSPNTPG Sbjct: 121 DNLIANLKAAKSGALIGVNIGKNKDTPVEQGKDDYLICMDKVYEYAAYIAVNISSPNTPG 180 Query: 181 LRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNID 240 LR+LQYG+ LDDLL ++K KQ DL H KYVPIA+KIAPDLS+EE+ ++ADSL+++ D Sbjct: 181 LRSLQYGDLLDDLLGSLKAKQKDLAQKHGKYVPIALKIAPDLSDEEIQKIADSLIKNQFD 240 Query: 241 GVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDS 300 G IATNTTL R V G+ N ++TGGLSG+PL L ST +I++LS LNG++PIIGVGGI+S Sbjct: 241 GAIATNTTLSRDGVSGLMNANETGGLSGKPLNLLSTSVIKKLSSCLNGQIPIIGVGGINS 300 Query: 301 VIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTH 335 A +K+ AGAS+VQIYSGFI++GP LIK+I+ Sbjct: 301 AADAIDKLDAGASMVQIYSGFIYQGPKLIKDIIEA 335 >UniRef50_C0Z506 Dihydroorotate dehydrogenase n=8 Tax=Bacteria RepID=C0Z506_BREBN Length = 363 Score = 361 bits (927), Expect = 2e-98, Method: Composition-based stats. Identities = 159/341 (46%), Positives = 212/341 (62%), Gaps = 6/341 (1%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEAL-----VRQKVPAKPVNCMGLTFKN 56 Y +RK LFQ D E HE T LR + + + K G+TF N Sbjct: 1 MYQLIRKYLFQQDAEEIHEKTIGALRLVEDSAPGKSILKMIYQVKDQRLENKLWGMTFPN 60 Query: 57 PLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFN 116 P+GLAAG DK+ E ALGA+GFG +EIGT+TP+ QPGN KPRLFRL + + +INRMGFN Sbjct: 61 PVGLAAGFDKNAEVYHALGALGFGFVEIGTLTPQGQPGNPKPRLFRLPEHQAVINRMGFN 120 Query: 117 NLGVDNLVENV-KKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISS 175 N G +++ A+ D +GINIGKNK TP E+ DY CM+ +YAY Y INISS Sbjct: 121 NHGAYLASQHLVDYAYSDVPIGINIGKNKVTPNEEAAVDYSKCMDMLYAYGHYFVINISS 180 Query: 176 PNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLV 235 PNTP LR LQ E+L L+ A+K K +++ K PI +K+APD+S+E + V + V Sbjct: 181 PNTPNLRDLQETESLRHLVRAVKEKATEMEGRSIKKKPILLKVAPDMSDEHMRDVVHAAV 240 Query: 236 RHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGV 295 I G+IATNTTL R V G + ++ GGLSGRPL +ST ++ + E+ ++PIIGV Sbjct: 241 EEGISGIIATNTTLSREAVSGHRFAEEAGGLSGRPLTERSTAWVKEIYQEVGDKVPIIGV 300 Query: 296 GGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 GGI + A KI AGASLVQ+Y+G I++GP + K+I + Sbjct: 301 GGIYNGEDAYAKIRAGASLVQVYTGMIYQGPGIAKQINKKL 341 >UniRef50_B2UNA2 Dihydroorotate dehydrogenase n=8 Tax=Bacteria RepID=PYRD_AKKM8 Length = 348 Score = 347 bits (891), Expect = 3e-94, Method: Composition-based stats. Identities = 165/336 (49%), Positives = 228/336 (67%), Gaps = 1/336 (0%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLA 61 Y + LFQ++PE AH+ T LR LV +VP+ PV +G+ F N +GLA Sbjct: 5 LYSAAKSVLFQMNPETAHKVTLWGLRLAEKMRVLPLVMGEVPSDPVEILGMKFPNRVGLA 64 Query: 62 AGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVD 121 AG+DK+ + + A G GFG +E+GT+TPRPQPGN+KPRLFRL+ + +INRMGFNN G+ Sbjct: 65 AGMDKEADTVSAFGQAGFGFVEVGTLTPRPQPGNEKPRLFRLIPQKAIINRMGFNNEGIA 124 Query: 122 NLVENVKKA-HYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPG 180 VEN++ A + GVLG+NIGKNK TP E DYL C+ + A YIAIN SSPNTPG Sbjct: 125 AGVENIRSATRFHGVLGVNIGKNKITPNEDAAQDYLTCLRAAWPVADYIAINFSSPNTPG 184 Query: 181 LRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNID 240 LR LQ E LL ++K++Q++L A ++VPI +K+APD+++E + +++ + +D Sbjct: 185 LRDLQAAEPAARLLASLKSEQSNLAAETGRHVPIFMKVAPDVTDEHIAELSRVFLDEGLD 244 Query: 241 GVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDS 300 G+IATNTTL R V+ ++ GGLSG PL +STE+I + EL GR+PIIGVGGI + Sbjct: 245 GLIATNTTLSRVGVEANPRHEEAGGLSGAPLTERSTEVIGAFASELKGRIPIIGVGGIMN 304 Query: 301 VIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + A KI AGASLVQ+Y+GF+++GP LI+E V + Sbjct: 305 GVDAVAKIKAGASLVQLYTGFVYRGPDLIRECVEAM 340 >UniRef50_Q2Y5H8 Dihydroorotate dehydrogenase n=195 Tax=cellular organisms RepID=PYRD_NITMU Length = 348 Score = 346 bits (888), Expect = 6e-94, Method: Composition-based stats. Identities = 185/336 (55%), Positives = 225/336 (66%), Gaps = 2/336 (0%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 M Y +R +F L+PE AH F + + P + + MGLTF NP+GL Sbjct: 1 MLYSLLRPLVFALEPETAHGIAFNAMETAHRLGLYR--ARPAPCRSRSIMGLTFPNPVGL 58 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAGLDK+GE IDAL A+GFG IEIGTVTPRPQPGN KPRLFRL A +INRMGFNN G+ Sbjct: 59 AAGLDKNGEHIDALAALGFGFIEIGTVTPRPQPGNPKPRLFRLPQANSIINRMGFNNNGI 118 Query: 121 DNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPG 180 + LV NVK Y G+LGINIGKN DTPVE+ DDYLIC+ K Y YA YI +NISSPNTP Sbjct: 119 EGLVANVKAMDYKGILGINIGKNFDTPVEKAVDDYLICLRKAYRYASYITVNISSPNTPN 178 Query: 181 LRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNID 240 LR LQ LD LL +K Q L H KY P+ VKIAPDL E+ +A L++H +D Sbjct: 179 LRQLQQATELDSLLGTLKLNQQRLADEHGKYTPLLVKIAPDLELPEIDSIAALLMKHRVD 238 Query: 241 GVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDS 300 GVIATNTTL R+ V+ + + + GGLSG PL ++T ++ RL L G LPIIGVGGI Sbjct: 239 GVIATNTTLSRAGVETLPHAREAGGLSGAPLAKRATSVVARLHHALQGALPIIGVGGIMD 298 Query: 301 VIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 A EKIAAGASL+Q+YSG +++GP L+ EI + Sbjct: 299 AAGATEKIAAGASLIQVYSGLVYRGPHLVGEIAQVL 334 >UniRef50_B0W4C3 Dihydroorotate dehydrogenase, mitochondrial n=2 Tax=Culicini RepID=B0W4C3_CULQU Length = 397 Score = 345 bits (885), Expect = 1e-93, Method: Composition-based stats. Identities = 141/341 (41%), Positives = 194/341 (56%), Gaps = 14/341 (4%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLA 61 Y + + PE AH L+ P Q + T +NP+G+A Sbjct: 41 YENIFMPMVRMVPPELAHRLAVLGLKMEVVRPSF----QDPEVLRTQLLNKTLENPVGIA 96 Query: 62 AGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVD 121 AG DK GE + L +GFG +EIG+VTP PQPGN KPR+FRL + + ++NR GFN+ G + Sbjct: 97 AGFDKHGEAVKGLERLGFGFVEIGSVTPEPQPGNPKPRVFRLNEDKAIVNRYGFNSEGHE 156 Query: 122 NLVENVKKAHYDGV----LGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPN 177 + E +KK DG LGIN+G+NK + E +DY+ + K A Y+ +NISSPN Sbjct: 157 VVFERIKKLRQDGDLKVTLGINLGRNKKS--EDNIEDYVQGIRKFSVLADYLVVNISSPN 214 Query: 178 TPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLV-- 235 TPGLRT+Q L LLT I +N L ++ PI VKIAPDLS+ + ++ + Sbjct: 215 TPGLRTMQNKSTLQSLLTEIVKARNAL--PPNEQRPILVKIAPDLSDGCVQEIIAVIQKK 272 Query: 236 RHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGV 295 IDG+I +NTT+DR N Q GGLSG PL KST+++ ++ GR+PIIGV Sbjct: 273 ECAIDGLIVSNTTIDRPSELKSINAGQLGGLSGAPLSSKSTQLVAKVYKWTGGRVPIIGV 332 Query: 296 GGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 GGI S A EKI AGAS VQ+Y+ I+ GPP++ + + Sbjct: 333 GGIFSGRDAYEKILAGASAVQLYTALIYHGPPIVARVKEEL 373 >UniRef50_P32748 Dihydroorotate dehydrogenase, mitochondrial n=14 Tax=Drosophila RepID=PYRD_DROME Length = 405 Score = 345 bits (885), Expect = 2e-93, Method: Composition-based stats. Identities = 127/342 (37%), Positives = 199/342 (58%), Gaps = 13/342 (3%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 ++ FV A+ L E +H+ + P + G NP+G+ Sbjct: 45 LFRTFVMPAVRLLPAEASHQLAVLACK-YRLCPVSQYH--DDQNLHTSFFGRMLSNPIGI 101 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAG DK+ E +D L +GFG IE+GTVTP Q GN KPR+FRL + + +INR GFN+ G Sbjct: 102 AAGFDKNAEAVDGLQDLGFGFIEVGTVTPAAQEGNPKPRVFRLTEDKAIINRYGFNSDGH 161 Query: 121 DNLVENVKKAHYD----GVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSP 176 +++ ++ GV+G+N+G+NK T DY+ + A Y+ IN+SSP Sbjct: 162 QAVLQRLRLLRKKENFNGVVGVNLGRNKTTMS--PIADYVQGVRVFGPVADYLVINVSSP 219 Query: 177 NTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLV- 235 NT GLR +Q E L +LL + + ++ L +K VPI +K++PDLS +++ + + Sbjct: 220 NTKGLRDMQSKEKLRELLEQVNDTKSSLDK--NKNVPILLKLSPDLSLDDMKDIVWVIKR 277 Query: 236 -RHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIG 294 + +DG+I +NTT+ R ++ K ++TGGLSG PL+ +STE+I ++ +G++PIIG Sbjct: 278 KKSRVDGLIVSNTTVSRENIEKNKLAEETGGLSGPPLKARSTEMIAQMYQLTDGKIPIIG 337 Query: 295 VGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 VGG+ S A EKI AGAS VQIY+ +++GP L+++I + Sbjct: 338 VGGVASGYDAYEKIEAGASYVQIYTALVYEGPALVEDIKAEL 379 >UniRef50_A1WJ81 Dihydroorotate dehydrogenase n=250 Tax=Bacteria RepID=PYRD_VEREI Length = 360 Score = 345 bits (884), Expect = 2e-93, Method: Composition-based stats. Identities = 172/339 (50%), Positives = 216/339 (63%), Gaps = 5/339 (1%) Query: 3 YPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAA 62 Y R LF LD E AHE L R TP + + P+ GL F N +GLAA Sbjct: 6 YALTRPFLFGLDAEAAHELIIDLLARGQRTPLQWAWCNQTVDDPIELAGLRFPNRVGLAA 65 Query: 63 GLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDN 122 GLDK+ CIDALGAMGFG +E GTVTP+ QPGN +PR+FRL +A LINR+GFNN G+ Sbjct: 66 GLDKNARCIDALGAMGFGFVEAGTVTPQAQPGNPRPRMFRLPEARALINRLGFNNAGLQA 125 Query: 123 LVE-----NVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPN 177 V ++ A LG+NIGKN TP+ Q DYL C+E +Y +A Y+A+NISSPN Sbjct: 126 FVHNLQQSRLRAAGSALRLGLNIGKNASTPMAQASSDYLACLEGVYPHADYVALNISSPN 185 Query: 178 TPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRH 237 T LRTLQ ALD LL AI ++ L A H + VP+ VKIAPDL E +L +A +L RH Sbjct: 186 TQNLRTLQGDAALDHLLGAIAERRATLAARHGRRVPVFVKIAPDLDEAQLSLMAATLQRH 245 Query: 238 NIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGG 297 IDGVIATNTT+DR++VQG ++ ++GGLSG P+ S ++I +L L PIIGVGG Sbjct: 246 GIDGVIATNTTIDRAVVQGQRHAQESGGLSGAPVLQASNQVIGQLRAALGKGFPIIGVGG 305 Query: 298 IDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 I S A KI AGA LVQIY+G I++GP L+ + I Sbjct: 306 IMSAEDAVSKIRAGADLVQIYTGLIYEGPALVVQAARAI 344 >UniRef50_Q7PYN9 AGAP002037-PA (Fragment) n=10 Tax=cellular organisms RepID=Q7PYN9_ANOGA Length = 404 Score = 344 bits (882), Expect = 3e-93, Method: Composition-based stats. Identities = 138/343 (40%), Positives = 196/343 (57%), Gaps = 16/343 (4%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLA 61 Y + + PE AH+ ++ P Q +G+ F NP+G+A Sbjct: 45 YNNVFMPIVRLIPPETAHDLAVLGVKWKLFRPPY----QDTDRLRTRLLGMAFSNPIGIA 100 Query: 62 AGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVD 121 AG DK GE + L +GFG +EIG+VTP PQPGN +PR+FRL + + ++NR GFN+ G D Sbjct: 101 AGFDKHGEAVQGLQLIGFGFVEIGSVTPEPQPGNARPRIFRLNEDKAIVNRYGFNSEGHD 160 Query: 122 NLVENVKKAHYDGV------LGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISS 175 + E +++ LGIN+GKNK + DY+ +++ A Y+ IN+SS Sbjct: 161 VVYERLRECREQQPPDQRVALGINLGKNKLSL--DAIADYVQGVKRFGTLADYLVINVSS 218 Query: 176 PNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADS-- 233 PNTPGLRT+Q L LLT + + L A + PI +K+APDLSEE+L ++ D Sbjct: 219 PNTPGLRTMQSKSTLQTLLTEVLKARASLPANEQR--PILLKLAPDLSEEDLREIVDVVR 276 Query: 234 LVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPII 293 +DG+I +NTT+DR N Q GGLSG PL+ +ST +I R+ G++PII Sbjct: 277 AKACAVDGLIVSNTTIDRPATLRSVNAGQLGGLSGPPLKHRSTAMIARVYKLTEGKIPII 336 Query: 294 GVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 GVGGI + A EKI AGAS VQ+Y+ FIF GPP++ +I + Sbjct: 337 GVGGIFTGEDAFEKIEAGASAVQLYTSFIFHGPPVVPKIKREL 379 >UniRef50_A5EV79 Dihydroorotate dehydrogenase n=3 Tax=Gammaproteobacteria RepID=PYRD_DICNV Length = 337 Score = 341 bits (874), Expect = 2e-92, Method: Composition-based stats. Identities = 167/334 (50%), Positives = 212/334 (63%), Gaps = 8/334 (2%) Query: 3 YPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAA 62 YP +R LF L+PE AH T Q L R + + P++ +G TF N LGLAA Sbjct: 4 YPHLRPLLFCLNPEIAHNLTLQILSRAAV-----FIPRIKAGNPIHLLGHTFPNRLGLAA 58 Query: 63 GLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDN 122 GLDK+ I A +GFG IE+GT TPRPQ GN KPRLFRL + + +IN MGFNN GV Sbjct: 59 GLDKNAVAISAFDRLGFGFIEVGTATPRPQSGNPKPRLFRLPEHQAIINCMGFNNDGVVA 118 Query: 123 LVENVK--KAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPG 180 L + V K ++GINIGKNK TP E+ DDYLI M Y YA Y+AINISSPNT G Sbjct: 119 LCQQVAAVKKRTRALIGINIGKNKLTPNERAADDYLIAMSTAYPYADYLAINISSPNTVG 178 Query: 181 LRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNID 240 LR LQ+G AL +LL +K +++ L A++ K VP+ VKIAPD E+L ++ + ID Sbjct: 179 LRDLQHGAALCELLQRLKTERDKLSAVYEKTVPLLVKIAPDNEREQLDEMLSIIEDSGID 238 Query: 241 GVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDS 300 G+IATNTTLD++ V G + D+ GGLSG+PL KST+II + L LP+I GG+ S Sbjct: 239 GIIATNTTLDKTAVTGHRYADEQGGLSGKPLTEKSTKIIAHIRERL-PDLPLIASGGVMS 297 Query: 301 VIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVT 334 K+ AGA LVQIYSG I+ GP LIK+ + Sbjct: 298 ADDYYAKLEAGADLVQIYSGLIYHGPQLIKDCLR 331 >UniRef50_A6H0L5 Dihydroorotate dehydrogenase n=28 Tax=Bacteria RepID=PYRD_FLAPJ Length = 350 Score = 340 bits (871), Expect = 6e-92, Method: Composition-based stats. Identities = 165/347 (47%), Positives = 208/347 (59%), Gaps = 13/347 (3%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTP-----FEALVRQKVPAKPVNCMGLTFK 55 MY +R LF DPE+ H FTF +R I P F++L GL FK Sbjct: 1 MYKLIIRPILFCFDPEKVHYFTFSLIRTIAKIPGFTSIFKSLYEVNDKRLEREVFGLKFK 60 Query: 56 NPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGF 115 NP+GLAAG DKD + L GFG IEIGT+TP+ Q GN K RLFRL + +INRMGF Sbjct: 61 NPVGLAAGFDKDAKLYKELSNFGFGFIEIGTLTPKGQEGNPKKRLFRLQEDSAIINRMGF 120 Query: 116 NNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISS 175 NN GV VE +KK + ++G NIGKNK TP E DY IC + +Y Y Y +N+SS Sbjct: 121 NNGGVLEAVERLKKNN-GVLIGGNIGKNKLTPNENATSDYEICFDALYDYVDYFVVNVSS 179 Query: 176 PNTPGLRTLQYGEALDDLLTAIKNKQNDLQ------AMHHKYVPIAVKIAPDLSEEELIQ 229 PNTP LR LQ E L LL ++NK + Q A PI +KIAPDL+ E+L+ Sbjct: 180 PNTPNLRELQEKEPLTQLLNTLQNKNQNKQKQTRDGAQSSGAKPILLKIAPDLTNEQLLD 239 Query: 230 VADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGR 289 + D + I G+IATNTT+ R + N + GGLSG+PL +STE+IR LS + N Sbjct: 240 IIDIVKTTKIAGIIATNTTISREGL-QSINRIEMGGLSGKPLTNRSTEVIRFLSQKSNKA 298 Query: 290 LPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 PIIGVGGI V A EK+ AGASL+Q+Y+GFI++GP L+K I I Sbjct: 299 FPIIGVGGIHCVQDAIEKLEAGASLIQLYTGFIYEGPALVKAINKEI 345 >UniRef50_A1WTJ3 Dihydroorotate dehydrogenase n=1 Tax=Halorhodospira halophila SL1 RepID=PYRD_HALHL Length = 342 Score = 339 bits (870), Expect = 7e-92, Method: Composition-based stats. Identities = 149/334 (44%), Positives = 215/334 (64%), Gaps = 1/334 (0%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLA 61 Y +R+ LF+L+PE+AH + Q R VR +PA P MG+ F NP+GLA Sbjct: 1 MYALIRQLLFRLEPEQAHRVSMQLARLGLRIAAVPGVR-SLPAVPRRVMGIDFPNPVGLA 59 Query: 62 AGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVD 121 AG DKDGE +D L +GFG +E+GTVTPR QPGN +PR+FR+ + E LINRMGFNN G + Sbjct: 60 AGFDKDGEYMDVLEQLGFGFLELGTVTPRAQPGNPQPRVFRIPEHEALINRMGFNNQGAE 119 Query: 122 NLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGL 181 LV ++ + + GV+GINIGKN+DTP E+ +DY + +Y A Y+A+N+SSPNTPGL Sbjct: 120 PLVRRLEVSRHRGVVGINIGKNRDTPPERAVEDYAQALGMVYGVADYVAVNLSSPNTPGL 179 Query: 182 RTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDG 241 R LQ+ AL +L+ ++ ++ L +H K VP+ VKIAPD EL D L+ +DG Sbjct: 180 RDLQHEGALRNLIDRLQTERKRLAELHDKRVPLVVKIAPDWEAGELDATLDILLERRVDG 239 Query: 242 VIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSV 301 ++ATNTTL R+ V+ ++GGLSG PL+ ++ ++ +++ + R +I GGI S Sbjct: 240 IVATNTTLGRTGVEQTPQARESGGLSGAPLREQAEWVLEQVAARRDRRTALIAAGGIMSG 299 Query: 302 IAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTH 335 ++ GA LVQ+Y+G I++GP L++E V Sbjct: 300 EDVTRRLDLGADLVQLYTGMIYRGPGLVQEAVRA 333 >UniRef50_Q5PR57 Dihydroorotate dehydrogenase n=20 Tax=cellular organisms RepID=Q5PR57_DANRE Length = 407 Score = 339 bits (870), Expect = 8e-92, Method: Composition-based stats. Identities = 131/344 (38%), Positives = 198/344 (57%), Gaps = 16/344 (4%) Query: 2 YYPFVRKALFQ-LDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 Y + L + + E AH + + + + V+ MG F+NP+G+ Sbjct: 36 YASALMPVLQRFVGGETAHLMAVRLIGLGL---VPRNNYKDPTSLEVHVMGRKFQNPVGM 92 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAG DK GE +D L +GFG +E+GTVTP+PQ GN KPR+FRL + +INR GFN+ G+ Sbjct: 93 AAGFDKHGEAVDGLYRLGFGFVEVGTVTPKPQDGNPKPRVFRLESDQAVINRYGFNSCGL 152 Query: 121 DNLVENVKKA--------HYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAIN 172 + E +K LGIN+GKNK +P DY+ + + A Y+ +N Sbjct: 153 SAVHERLKAREHVQSELTKAGKPLGINLGKNKLSP--DAVSDYVEGVRTLGPLADYLVVN 210 Query: 173 ISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVAD 232 +SSPNTPGLR LQ E L LL + +++ L+ P+ VKIAPDL+ ++ +A+ Sbjct: 211 VSSPNTPGLRDLQGKEELRHLLDKVVKERDSLR--IENRPPVLVKIAPDLTTQDKQDIAE 268 Query: 233 SLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPI 292 ++ +DGV+ +NTT+ R N +TGGLSG+PL+ ST+ +R + G+LPI Sbjct: 269 VIMEVGVDGVMVSNTTVSRPDTLKDPNRVETGGLSGQPLKELSTQTVREMYTLTQGKLPI 328 Query: 293 IGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 +GVGG+ S A +KI AGASLVQ+Y+ +++GPP++ +I + Sbjct: 329 VGVGGVASGQDAMDKIRAGASLVQLYTALVYQGPPVVNKIKREL 372 >UniRef50_A9WDI1 Dihydroorotate dehydrogenase n=13 Tax=Bacteria RepID=PYRD_CHLAA Length = 363 Score = 339 bits (870), Expect = 8e-92, Method: Composition-based stats. Identities = 149/347 (42%), Positives = 203/347 (58%), Gaps = 12/347 (3%) Query: 2 YYPFVRKALFQL---DPERAHEFTFQQLRRITGTPFEA-----LVRQKVPAKPVNCMGLT 53 Y +R LF+L D E AHE T L I+ + L + G+ Sbjct: 9 YRYGIRPILFRLGRGDAETAHERTLHILALISRSRLLCKTIGYLTTIRDQRLQRTVCGIP 68 Query: 54 FKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRM 113 F NP+GLAAG+DKDG I A A+GFG +E+GTVT PQPGN +PRLFRL + E LINRM Sbjct: 69 FPNPVGLAAGMDKDGVAIPAWAALGFGFVEVGTVTHHPQPGNPRPRLFRLPEQEALINRM 128 Query: 114 GFNNLGVDNLVENVKKA-HYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAIN 172 GFNN G +L + + +G++IGK+K TP+EQ DDY +++ YA YIAIN Sbjct: 129 GFNNQGAASLARRLARLQPAPIPVGVSIGKSKITPLEQAIDDYRASFRQLFPYAAYIAIN 188 Query: 173 ISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHK-YVPIAVKIAPDLSEEELIQVA 231 +SSPNTPGLR LQ + L LL A+++ +L + P+ VKIAPDLS+ + +V Sbjct: 189 VSSPNTPGLRQLQDADQLRALLAALQHDNAELGRTDQRGPRPLLVKIAPDLSDTAIEEVL 248 Query: 232 DSLVRHNIDGVIATNTTLDRSLVQG--MKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGR 289 H + G+IATNTT+ R + G + + GGLSGRPL ++ ++R ++ R Sbjct: 249 TVCADHGVAGIIATNTTISREGLTGVDPRLAAEAGGLSGRPLIARALHVVRLIARLTGNR 308 Query: 290 LPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 LPIIGVGGI + + AGASL+QIY+G ++ GP L + I I Sbjct: 309 LPIIGVGGIHTPDDGLRMLEAGASLIQIYTGLVYYGPLLPRRINRAI 355 >UniRef50_Q02127 Dihydroorotate dehydrogenase, mitochondrial n=39 Tax=cellular organisms RepID=PYRD_HUMAN Length = 395 Score = 338 bits (866), Expect = 2e-91, Method: Composition-based stats. Identities = 133/344 (38%), Positives = 193/344 (56%), Gaps = 16/344 (4%) Query: 2 YYPFVRKALF-QLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 Y + L LDPE AH + + P + V +G F+NP+G+ Sbjct: 37 YAEHLMPTLQGLLDPESAHRLAVRF-TSLGLLPRARFQDSDM--LEVRVLGHKFRNPVGI 93 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAG DK GE +D L MGFG +EIG+VTP+PQ GN +PR+FRL + + +INR GFN+ G+ Sbjct: 94 AAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGL 153 Query: 121 DNLVENVKKAHYDG--------VLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAIN 172 + ++ LG+N+GKNK + +DY + + A Y+ +N Sbjct: 154 SVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSV--DAAEDYAEGVRVLGPLADYLVVN 211 Query: 173 ISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVAD 232 +SSPNT GLR+LQ L LLT + +++ L+ +H + VKIAPDL+ ++ +A Sbjct: 212 VSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPA--VLVKIAPDLTSQDKEDIAS 269 Query: 233 SLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPI 292 + IDG+I TNTT+ R +TGGLSG+PL+ ST+ IR + GR+PI Sbjct: 270 VVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPI 329 Query: 293 IGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 IGVGG+ S A EKI AGASLVQ+Y+ F GPP++ ++ + Sbjct: 330 IGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKREL 373 >UniRef50_Q3IU78 Dihydroorotate dehydrogenase n=13 Tax=cellular organisms RepID=PYRD_NATPD Length = 350 Score = 337 bits (864), Expect = 3e-91, Method: Composition-based stats. Identities = 136/339 (40%), Positives = 197/339 (58%), Gaps = 15/339 (4%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQK----VPAKPVNCMGLTFKNP 57 Y ++ ALFQLD E AH + L I GTP E +V P V+ G TF NP Sbjct: 3 LYQLLKPALFQLDAETAHGLGHRVLDGIQGTPLERIVADYCTVVDPRLRVDAFGQTFPNP 62 Query: 58 LGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNN 117 +G+AAG DK+ E DALGA+GFG +E+G VT PQ GN +PR+FRL + LINRMGFNN Sbjct: 63 VGVAAGFDKNAEIPDALGALGFGHVEVGGVTAEPQAGNPRPRMFRLAEDRALINRMGFNN 122 Query: 118 LGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPN 177 G D + E + +G+NIGK+K + + DY E++ Y +N+SSPN Sbjct: 123 DGADIVGERLAATDCRVPVGVNIGKSKSAANDDAEADYQYTYERVADGGDYFVVNVSSPN 182 Query: 178 TPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRH 237 TPGLR LQ + L+ +L +++ P+ VK++PDL++ + + + Sbjct: 183 TPGLRELQSRDRLESILGTLQD---------DGASPLLVKLSPDLTDAAIEDAIEVVEDL 233 Query: 238 NIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGG 297 +DG+IATNTT R D+ GGLSG P+ +ST+I+R ++ + PI+GVGG Sbjct: 234 GLDGIIATNTTTKRPASLHSDAADEEGGLSGAPITDESTDIVRFIAKRTDK--PIVGVGG 291 Query: 298 IDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 ID +A EKI GAS+VQ+Y+G +++GP + ++I + Sbjct: 292 IDDAESAYEKIRNGASVVQLYTGLVYEGPTIARDINRGL 330 >UniRef50_A9CK85 Dihydroorotate dehydrogenase n=16 Tax=Alphaproteobacteria RepID=PYRD_AGRT5 Length = 363 Score = 337 bits (864), Expect = 3e-91, Method: Composition-based stats. Identities = 150/336 (44%), Positives = 204/336 (60%), Gaps = 5/336 (1%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 ++ RK LF +DPE+AH + L+ + P GL F NPLG+ Sbjct: 4 LFSSVGRKGLFLIDPEKAHGLSVAALKSG---FLPTCMVPHDPRLQQTVAGLVFPNPLGM 60 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAG DK+ E L +GFG EIGTVTPR Q GN KPR+FRLV+ EG+INR+GFNN G Sbjct: 61 AAGYDKNAEVPGPLLRLGFGFTEIGTVTPRAQSGNPKPRIFRLVEDEGVINRLGFNNEGH 120 Query: 121 DNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPG 180 +E + +A G++G+NIG NKD+ E DY+ +E YA A Y +NISSPNTPG Sbjct: 121 AAALERLTQARLRGIVGVNIGANKDS--EDRIADYVQGIEAFYAVASYFTVNISSPNTPG 178 Query: 181 LRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNID 240 LR LQ E+L LLTA+ ++ K +PI +KIAPDL+EE L VA+ + H++D Sbjct: 179 LRDLQARESLAALLTAVLERRKTEAERLGKRIPIFLKIAPDLTEEGLDDVAEEALAHDLD 238 Query: 241 GVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDS 300 G+I +NTTL R ++ + + GGLSG+PL ST ++ ++ + LPIIGVGG+ S Sbjct: 239 GLIVSNTTLSREGLRPGPHRGEAGGLSGKPLFELSTTVLAKMRRRVGANLPIIGVGGVSS 298 Query: 301 VIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 A EK+ AGA LVQ+YS +++GP L IV + Sbjct: 299 AETALEKVRAGADLVQLYSCMVYEGPGLPSAIVKGM 334 >UniRef50_P57443 Dihydroorotate dehydrogenase n=2 Tax=Proteobacteria RepID=PYRD_BUCAI Length = 337 Score = 336 bits (862), Expect = 7e-91, Method: Composition-based stats. Identities = 195/337 (57%), Positives = 249/337 (73%), Gaps = 1/337 (0%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKV-PAKPVNCMGLTFKNPLG 59 M+Y F+RK LF L+PE+AH T + L F+ + + +K + CMGL F N LG Sbjct: 1 MFYYFIRKLLFLLEPEKAHFLTLKYLNIKNIQFFDFFFYKTIILSKKIKCMGLIFDNKLG 60 Query: 60 LAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLG 119 AAG+DK+GE IDAL +GFG IE+GTVTP PQ GN KPR+FR+V EG+INRMGFNNLG Sbjct: 61 TAAGIDKNGEYIDALSKLGFGFIEVGTVTPLPQVGNPKPRMFRIVSMEGIINRMGFNNLG 120 Query: 120 VDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTP 179 +DNL+ N+KK+++ G++G+NIGKNK T +E DDYLIC+EKIY YAGYIAINISSPNT Sbjct: 121 IDNLIRNIKKSNFKGIIGVNIGKNKSTSLENSVDDYLICIEKIYCYAGYIAINISSPNTT 180 Query: 180 GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNI 239 LR LQYG LL IK KQ +L + KYVPIA+KI+PDLS +EL+ ++ L+R+ I Sbjct: 181 NLRNLQYGILFKKLLYKIKKKQKELHKKYLKYVPIAIKISPDLSIKELVDISKQLIRYKI 240 Query: 240 DGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGID 299 D VIATNTTLD S + G+KN + GGLSG PLQ KST I LS L ++PIIGVGGI+ Sbjct: 241 DAVIATNTTLDHSSLFGLKNSSEQGGLSGLPLQKKSTNTISILSKSLQKKIPIIGVGGIN 300 Query: 300 SVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 S+ +A+EKI +GA+L+QIYSG ++ GP LIK+I+ HI Sbjct: 301 SINSAKEKIESGATLIQIYSGLVYHGPKLIKKIINHI 337 >UniRef50_D2S350 Dihydroorotate dehydrogenase n=2 Tax=Halobacteriaceae RepID=D2S350_9EURY Length = 356 Score = 335 bits (860), Expect = 1e-90, Method: Composition-based stats. Identities = 134/341 (39%), Positives = 199/341 (58%), Gaps = 14/341 (4%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGTP-----FEALVRQKVPAKPVNCMGLTFKN 56 Y VR F+L E AH+ + LR T A R PA V+ TF N Sbjct: 3 LYSRVRPLAFKLPAETAHDLGKRTLRAAQSTWPTRRALAAAYRYDHPALEVDLFDSTFPN 62 Query: 57 PLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFN 116 P+G+AAG DK+ E AL A+GFG +EIGTVTP PQ GND+PRLFRL + EG+INRMGFN Sbjct: 63 PVGIAAGFDKNAEVTHALEALGFGFVEIGTVTPYPQEGNDRPRLFRLREDEGMINRMGFN 122 Query: 117 NLGVDNLVENVKKAHYDG-VLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISS 175 G++ + E +++ G LG+NIGK + + +DY +++ +A Y+ +N+S Sbjct: 123 GQGMETVKERLEEDGTPGFPLGVNIGKMNSSTEREAIEDYRRVFDRVSPFADYVVVNVSC 182 Query: 176 PNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLV 235 PNTP E L + ++ + + VP+ VKI PD E+ ++ + D + Sbjct: 183 PNTPDEFNEASPEHLRAIFETLEAEND-------GNVPMLVKIGPDEPEDAILDLVDIVQ 235 Query: 236 RHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGV 295 +DG++ATNT+ R ++ ++ GGLSG P++ +ST++IR ++ +G LPI+GV Sbjct: 236 EFGLDGIVATNTSTAREGLE-SPAREEWGGLSGAPIEDRSTDVIRTIAGHTDGELPIVGV 294 Query: 296 GGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 GG+DS +A EKI AGASLVQ+Y+GF+++GP I + Sbjct: 295 GGVDSAASAYEKIRAGASLVQLYTGFVYRGPSTAGRINQGL 335 >UniRef50_Q2YWG7 Dihydroorotate dehydrogenase n=56 Tax=Staphylococcus RepID=Q2YWG7_STAAB Length = 354 Score = 335 bits (859), Expect = 2e-90, Method: Composition-based stats. Identities = 123/340 (36%), Positives = 187/340 (55%), Gaps = 11/340 (3%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGTPF-----EALVRQKVPAKPVNCMGLTFKN 56 Y ++ LF+++PE+AH T L+ + P + L K P G T+ N Sbjct: 1 MYKLIKPFLFKIEPEKAHGLTIDALKTLQKFPVLFPVVDKLFTYKNPTLSQTIQGNTYDN 60 Query: 57 PLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFN 116 P+GLAAG DK E AL +GFG++E+G +TP+PQPGN +PR+FRL++ + LINRMGFN Sbjct: 61 PIGLAAGFDKSCEVPKALEHLGFGALELGGITPKPQPGNPQPRMFRLLEDDALINRMGFN 120 Query: 117 NLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSP 176 N+G++ + +++K Y +GIN+G NK TP E DY+ ++ + +NISSP Sbjct: 121 NIGMNKALSHLRKNAYQVPVGINVGVNKMTPYEARYQDYIKVIDTFKHDVSFFTVNISSP 180 Query: 177 NTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVR 236 NT L+ + L A+ + H VPI +K+ D+ + L + ++ Sbjct: 181 NTENLQNFHDKDEFSMLCQAL----TTFKKQHDVTVPIYLKLTSDMDFDGLKALLPAITE 236 Query: 237 HNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVG 296 DG+I NTT R + N + GGLSGRPL ++ ++I+ + NG IIG G Sbjct: 237 T-FDGIILANTTRQRDGLT-SANKVEEGGLSGRPLFERNLKLIKYAYQQTNGEFLIIGTG 294 Query: 297 GIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 G+ S A + + GASL+QIYS + +GP L K++ I Sbjct: 295 GVFSTEDAIKMMRHGASLIQIYSSLVIEGPGLTKKMNKGI 334 >UniRef50_C2QE06 Dihydroorotate dehydrogenase n=3 Tax=Bacillus cereus RepID=C2QE06_BACCE Length = 350 Score = 335 bits (858), Expect = 2e-90, Method: Composition-based stats. Identities = 147/330 (44%), Positives = 201/330 (60%), Gaps = 7/330 (2%) Query: 13 LDPERAHEFTFQQLRRITGTPFEALV-----RQKVPAKPVNCMGLTFKNPLGLAAGLDKD 67 +DPE+AH T L+ + F + R + + F NP+GLAAG DK Sbjct: 1 MDPEKAHTRTIHALKMMQSFSFARNMYNKNMRLNDSRLECKLLDIKFPNPIGLAAGFDKF 60 Query: 68 GECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVEN- 126 + L ++GFGS+E+G++TP+PQ GN KPRL+RL + LINRMGFN+ G+D +N Sbjct: 61 ADVYPGLASLGFGSVEVGSITPKPQSGNPKPRLYRLPEDTALINRMGFNSEGLDRAKQNF 120 Query: 127 VKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQY 186 + + LGIN+GKNKDTP DY +E +Y+Y Y INISSPNT GLR LQY Sbjct: 121 MTLPRPNIPLGINLGKNKDTPNSDATLDYQKGLETLYSYGDYFVINISSPNTEGLRDLQY 180 Query: 187 GEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATN 246 + L LL +I +K+N+L H++Y PI +KIAPDL+ E+L V + ID VIA N Sbjct: 181 VDTLKPLLASILDKRNELCKKHNQYRPIILKIAPDLTPEQLEGVISIIQEVKIDAVIAAN 240 Query: 247 TTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAARE 306 TT+ R+ + Q GGLSG+PL +STEII ++ + G LPIIG GG+ + A E Sbjct: 241 TTISRTNLNSKFQK-QNGGLSGKPLNHRSTEIISKIYRQTQGNLPIIGSGGVFTGEDAYE 299 Query: 307 KIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 KI +GASL+QIY+ I++GP + K I I Sbjct: 300 KIKSGASLIQIYTSMIYRGPSVAKHINQEI 329 >UniRef50_C9YAQ9 Dihydroorotate dehydrogenase n=2 Tax=cellular organisms RepID=C9YAQ9_9BURK Length = 389 Score = 334 bits (856), Expect = 3e-90, Method: Composition-based stats. Identities = 165/343 (48%), Positives = 213/343 (62%), Gaps = 15/343 (4%) Query: 3 YPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAA 62 Y R+ LF LDPE AH+ T L G P + PV GL F N +G+AA Sbjct: 36 YALARRVLFNLDPEVAHDITMAGLAASQGNPLKLAYCNSRVDDPVTIAGLQFPNRVGMAA 95 Query: 63 GLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDN 122 GLDK+ CID LGAMGFG +E+GTVTP QPGN KPR+FRL +A LINR+GFNN G+D Sbjct: 96 GLDKNARCIDGLGAMGFGFVEVGTVTPLAQPGNPKPRMFRLPEANALINRLGFNNHGLDA 155 Query: 123 LVENVKKAHYDG------VLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSP 176 + NV+++ +LG+NIGKN TP+E+ DDYLIC++ +Y +A YI +NISSP Sbjct: 156 FIANVQRSALRQSKNPSLLLGLNIGKNAATPIEKATDDYLICLDGVYPHADYITVNISSP 215 Query: 177 NTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVR 236 NT LR+LQ +ALD LL AI ++ L H + P+ +KIAPDL +++ +A +L R Sbjct: 216 NTKNLRSLQSDDALDALLGAIAERREQLAQKHGQRKPVFLKIAPDLEADQVAVIAATLKR 275 Query: 237 HNID---------GVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELN 287 + D GVI TNTTL R V+GM + ++ GGLSG P+ KS +I +L L Sbjct: 276 YGTDSSGKVNNAWGVIGTNTTLSRGAVKGMPHAEEMGGLSGAPVLEKSNAVIGQLRAALG 335 Query: 288 GRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIK 330 PIIGVGGI S A KI AGA VQIY+G I+ GP L+K Sbjct: 336 KDFPIIGVGGIMSAADAVSKIKAGADAVQIYTGLIYSGPQLVK 378 >UniRef50_A7NLW9 Dihydroorotate dehydrogenase n=18 Tax=Bacteria RepID=PYRD_ROSCS Length = 367 Score = 331 bits (849), Expect = 2e-89, Method: Composition-based stats. Identities = 139/342 (40%), Positives = 201/342 (58%), Gaps = 11/342 (3%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEA-----LVRQKVPAKPVNCMGLTFK 55 M Y +R LF+LD ERAH+ R + P L PA V GL F Sbjct: 1 MLYHLIRPLLFRLDAERAHDVVTAMFRATSRMPLLPRLISALYAWDDPALMVEWAGLRFA 60 Query: 56 NPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGF 115 +PLG+AAG DK + +DAL +GF +E+GTVTPRPQPGN PRLFRL + LINR+GF Sbjct: 61 SPLGVAAGFDKRADLVDALALLGFSHVEVGTVTPRPQPGNPGPRLFRLPEDMALINRLGF 120 Query: 116 NNLGVDNLVENVK-KAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINIS 174 N+ G+ + + ++ + ++G+NIGKN+DTP+E+ +DY + A Y+A+NIS Sbjct: 121 NSHGMVAVAKALRARRSRRVIVGVNIGKNRDTPLERAVEDYAATFVALAPLADYVAVNIS 180 Query: 175 SPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSL 234 SPNTPGLR L AL++LL + + L PIA+KI+PD + +++ +V + Sbjct: 181 SPNTPGLRRLHERAALEELLRELMRLNHGL----LYPRPIALKISPDETLDQIEEVVRAG 236 Query: 235 VRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIG 294 + IATNTTL R + + ++TGGLSGRPL ++ ++IR + G P+IG Sbjct: 237 CEAGVAAFIATNTTLAREGL-RSRLANETGGLSGRPLAPRARQVIRAIYRLTRGTPPVIG 295 Query: 295 VGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 VGG+ + A I AGA LVQ+Y+G ++ GP + +EI + Sbjct: 296 VGGVLTADDAYAHIRAGARLVQLYTGMVYAGPAIAREIKRGL 337 >UniRef50_Q75XR0 Dihydroorotate dehydrogenase n=3 Tax=Eukaryota RepID=Q75XR0_EUGGR Length = 435 Score = 328 bits (841), Expect = 2e-88, Method: Composition-based stats. Identities = 132/349 (37%), Positives = 187/349 (53%), Gaps = 20/349 (5%) Query: 3 YPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAA 62 + L+ E AH+ + V + GL F NPLGLAA Sbjct: 59 DNVAMPLVRLLEAEAAHDCAIRAASWGL---VPRDVHPDPADLEMEVWGLKFSNPLGLAA 115 Query: 63 GLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDN 122 G DK GE +DAL GFG +EIGTVTP PQPGN PR+FRL +INR GFN+ G+ Sbjct: 116 GFDKHGEAVDALLGTGFGFVEIGTVTPLPQPGNPSPRMFRLEQDRAIINRYGFNSQGLAA 175 Query: 123 LVENV-----KKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPN 177 + + + + A G++G+N+GKNK E DY + ++ YA Y+ IN+SSPN Sbjct: 176 VRKRLEARQHRPAPRGGLVGVNVGKNKLQ--EDAAADYSKGLRELGPYADYLVINVSSPN 233 Query: 178 TPGLRTLQYGEALDDLLTAIKNKQNDLQA----------MHHKYVPIAVKIAPDLSEEEL 227 TPGLR LQ A+ DL+ A ++++ +P+ +KIAPDL+ EE Sbjct: 234 TPGLRNLQKRSAMADLIKASMVARDEVVRDADGRRAAAGKSAAPLPLLIKIAPDLTAEEK 293 Query: 228 IQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELN 287 +A+ ++ IDG+I +NTT+ R + QTGGLSG PL+ ST+ IR + Sbjct: 294 QDIAEVVMETKIDGLIVSNTTVSRPASLLSPHKGQTGGLSGAPLREMSTQAIRDMYALTR 353 Query: 288 GRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 G +PI+GVGG+ + EK+ AGASLVQ+YS ++ GP + + Sbjct: 354 GTVPIVGVGGVATGEDVLEKLKAGASLVQMYSMLVYDGPGAPPRVKKGL 402 >UniRef50_Q1V0W4 Dihydroorotate dehydrogenase n=5 Tax=Bacteria RepID=Q1V0W4_PELUB Length = 350 Score = 327 bits (838), Expect = 4e-88, Method: Composition-based stats. Identities = 135/335 (40%), Positives = 202/335 (60%), Gaps = 7/335 (2%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLA 61 + R +F++DPE AH + L+ + P A + P N G NP+G+A Sbjct: 1 MFSKFRSLIFKIDPETAHNLAIKSLK-LNILPNIADQNKGDPIFKTNLFGKNIDNPIGMA 59 Query: 62 AGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVD 121 AG DK+ E + L +GFG +E+GTVTP Q GN KPR+FRLV+ + LINR+GFNNLG + Sbjct: 60 AGFDKNAEVYNPLFKLGFGFVEVGTVTPLEQYGNPKPRVFRLVEDQALINRLGFNNLGAE 119 Query: 122 NLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGL 181 N+ ++ + G+LGINIG NKD+ E +DYLI + Y A YI +NISSPNT L Sbjct: 120 NISHRIRSNSHKGLLGINIGPNKDS--EDRLNDYLIGLRNFYDIADYITVNISSPNTENL 177 Query: 182 RTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDG 241 R D+LL AI+ ++ L+ +PI VKI+PD+S+E++ ++ L++H + Sbjct: 178 RAFHDETKFDELLNAIEKEKVKLK----SKIPIVVKISPDISDEQIELISKILIKHKVSA 233 Query: 242 VIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSV 301 +I +NTT Q GGLSG+PL+ ++ ++I + L G++ IIGVGG+DS Sbjct: 234 IIVSNTTAKNREKLNNILKHQKGGLSGKPLEEEANKLISKFYKLLKGKIEIIGVGGVDSG 293 Query: 302 IAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 +A +K AGAS VQ+Y+G +F+GP ++ +I + Sbjct: 294 ESAYKKFQAGASYVQLYTGMVFQGPNIVGKIKKEL 328 >UniRef50_Q9RX14 Dihydroorotate dehydrogenase n=4 Tax=Bacteria RepID=PYRD_DEIRA Length = 369 Score = 326 bits (837), Expect = 5e-88, Method: Composition-based stats. Identities = 138/351 (39%), Positives = 194/351 (55%), Gaps = 17/351 (4%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQK----------VPAKPVNCMG 51 Y VR LF+LD E AH T + L +G P + + A G Sbjct: 1 MYQTVRPLLFRLDAEDAHHLTLRGLELASGVPLLPRLARTLTVPGTQGPGDAALRRTLWG 60 Query: 52 LT-----FKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDA 106 T F++PLGLAAGLDK+ + + A A GFG +E+GTVTP Q GN++PRLFRL + Sbjct: 61 QTPSEQTFESPLGLAAGLDKNAQAVPAFTAFGFGFVEVGTVTPLAQSGNERPRLFRLPED 120 Query: 107 EGLINRMGFNNLGVDNLVENVK-KAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAY 165 E LINRMGFNN G + + + +NIGKNK TP E +DY C+ + Sbjct: 121 EALINRMGFNNGGTAAMHARLAVLTDRAAPVWVNIGKNKVTPNEDAAEDYRKCVRALGDL 180 Query: 166 AGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEE 225 A +N+SSPNTPGLR LQ + L L+ A+ ++ + + P+ VK+APDL Sbjct: 181 ADAFVVNVSSPNTPGLRALQAADDLAALVRAVLDEVEAGRVRTLRRPPVLVKLAPDLHPA 240 Query: 226 ELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLE 285 + +++ G+I +NTTL R + N +Q GGLSGRPL +STE++R Sbjct: 241 DFEASVGAVLDAGASGLIISNTTLSRGGLSH-PNREQAGGLSGRPLTDRSTELVRDAYRL 299 Query: 286 LNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 G++PI+GVGG+ S A K+ AGA LV++YS I++GP L++EI + Sbjct: 300 TRGQVPIVGVGGVFSAEDAYAKLLAGADLVEVYSALIYRGPGLVREINAGL 350 >UniRef50_Q2RX27 Dihydroorotate dehydrogenase n=14 Tax=cellular organisms RepID=PYRD_RHORT Length = 367 Score = 325 bits (833), Expect = 2e-87, Method: Composition-based stats. Identities = 143/335 (42%), Positives = 192/335 (57%), Gaps = 7/335 (2%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLA 61 +Y + LDPERAH + L A P + G F NPLGLA Sbjct: 4 WYRLAWPLICGLDPERAHHLAIRALALGLAGHDRAA---DDPVLACSLWGRRFANPLGLA 60 Query: 62 AGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVD 121 AG DK+GE DAL +GFG +E+GTVTPRPQ GN +PRLFRL +INRMGFNN G++ Sbjct: 61 AGFDKNGEVADALFDLGFGFVEVGTVTPRPQAGNPRPRLFRLTQDRAVINRMGFNNQGME 120 Query: 122 NLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGL 181 + +A GVLGIN+GKNK T E DY + K+ A Y+ IN+SSPNTPGL Sbjct: 121 AMAARFVRARPRGVLGINLGKNKTT--EDAAGDYEAGIAKLAPLADYLVINVSSPNTPGL 178 Query: 182 RTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDG 241 R LQ E L L+ + A P+ +K+APDL++E++ +A+ + +DG Sbjct: 179 RALQGREPLSLLIAR--ARAALDAACPGLRPPLLLKVAPDLTDEDMADIAEVALGGGLDG 236 Query: 242 VIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSV 301 +I TNTT+ R + +TGGLSG PL+ ++ ++I RL G LP+IGVGGI Sbjct: 237 LICTNTTIARPKSLVSDHAGETGGLSGLPLRYRARQVIARLYGLTKGALPLIGVGGIGDG 296 Query: 302 IAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 A +I AGASL+QIYS +++GP L+ I + Sbjct: 297 AEAYARIRAGASLIQIYSALVYEGPGLVGRIKRDL 331 >UniRef50_A5UX75 Dihydroorotate dehydrogenase n=1 Tax=Roseiflexus sp. RS-1 RepID=PYRD_ROSS1 Length = 361 Score = 325 bits (832), Expect = 2e-87, Method: Composition-based stats. Identities = 142/341 (41%), Positives = 200/341 (58%), Gaps = 11/341 (3%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGTPF-----EALVRQKVPAKPVNCMGLTFKN 56 Y +R LF+LD ERAH+ T + LR + P AL + P V+ GL F N Sbjct: 4 LYALIRPLLFRLDAERAHDLTAKALRVTSRAPLLPRLIRALYAWEDPLLAVDWSGLHFAN 63 Query: 57 PLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFN 116 P+G+AAG DK + +D L +GFG IE+GTVTPRPQPGN +PRLFRL + LINR+GFN Sbjct: 64 PVGVAAGFDKRADLVDGLALLGFGHIEVGTVTPRPQPGNPRPRLFRLPEDTALINRLGFN 123 Query: 117 NLGV-DNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISS 175 + G+ + D ++G+NIGKN+DTP+E+ +DY+ + A Y+A+NISS Sbjct: 124 SPGMVAVARALRARRSRDVIVGVNIGKNRDTPLERAVEDYVATFVALAPIADYVAVNISS 183 Query: 176 PNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLV 235 PNTPGLR L AL+ LL + L PIA+K++PD + ++L V + Sbjct: 184 PNTPGLRRLHERAALETLLHEL----TRLNRALPHPRPIALKVSPDETPDQLEAVVRAGC 239 Query: 236 RHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGV 295 I IATNTTL R + +TGGLSGRPL ++ ++I + +G P+IGV Sbjct: 240 DAGIAAFIATNTTLARD-DLHSRLAIETGGLSGRPLTQRARQVIGAIYRLTHGAPPVIGV 298 Query: 296 GGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 GGI + A + I AGA L+QIY+G ++ GP + ++I + Sbjct: 299 GGIATAEDAYQHIRAGARLIQIYTGMVYAGPAIARDIKQGL 339 >UniRef50_Q5HL43 Dihydroorotate dehydrogenase n=8 Tax=Staphylococcus RepID=Q5HL43_STAEQ Length = 354 Score = 325 bits (832), Expect = 2e-87, Method: Composition-based stats. Identities = 125/340 (36%), Positives = 185/340 (54%), Gaps = 11/340 (3%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGTP-----FEALVRQKVPAKPVNCMGLTFKN 56 Y V+ LF+LDPERAH T L+ + L P + G++F N Sbjct: 1 MYKLVKPLLFKLDPERAHGLTINALKCVQKCSPILPIVNKLFTYNNPILTQHIHGISFDN 60 Query: 57 PLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFN 116 P+GLAAG DK E AL +GFG+IE+G +TP+PQPGN KPR++RL++ + LINRMGFN Sbjct: 61 PIGLAAGFDKSCEVPKALENIGFGAIELGGITPKPQPGNPKPRMYRLLEDDALINRMGFN 120 Query: 117 NLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSP 176 N G++ + N++ +G+N+G NK T E DY+ ++ + +NISSP Sbjct: 121 NKGMNKALSNLRNHSCSIPVGLNVGVNKTTSYENRYQDYIKVIDTFKNDVSFFTVNISSP 180 Query: 177 NTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVR 236 NT L+ + L A+ N +A ++ VPI +K+ D+ + ++ S+ Sbjct: 181 NTENLQNFHDEDEFSMLCDAL----NSFKAKNNINVPIFLKLTSDMELDGFKKILPSITD 236 Query: 237 HNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVG 296 DGV+ NTT R + KN Q GGLSGRPL ++ ++++ + G IIG G Sbjct: 237 T-FDGVMLANTTRQRDGLN-SKNKIQEGGLSGRPLFQRNLQLVKYAYQQTRGNFLIIGTG 294 Query: 297 GIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 GI S A + + GASL+QIYS + +GP L K++ I Sbjct: 295 GIFSSEDAIKMLRNGASLLQIYSSLVIEGPGLTKKMNKEI 334 >UniRef50_B6BWI2 Dihydroorotate oxidase n=1 Tax=beta proteobacterium KB13 RepID=B6BWI2_9PROT Length = 335 Score = 324 bits (831), Expect = 2e-87, Method: Composition-based stats. Identities = 140/336 (41%), Positives = 203/336 (60%), Gaps = 2/336 (0%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 M Y R +F L PE +H F + L+ + + K KP+ GL FKN +GL Sbjct: 1 MLYRLFRSVIFLLPPEFSHHFILKILKIVNFISLLKVKDIKN-EKPIFIKGLNFKNKVGL 59 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAG DK+ E + +GFG +E+GTVTP+PQ GN KPR+FR + LIN GFNN+G+ Sbjct: 60 AAGFDKNAEHMQIFENLGFGFLELGTVTPKPQSGNKKPRIFRDPKNDALINSFGFNNVGI 119 Query: 121 DNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPG 180 ++N+KK+ + V+GINIGKN TP E +DY+ CM + Y YA Y+ +NISSPNT Sbjct: 120 YKFIDNIKKSKINLVIGINIGKNALTPYEDSINDYIACMREAYVYADYLTVNISSPNTKN 179 Query: 181 LRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNID 240 LR L L + ++ ++N LQ K VPI +K++PD+ + ++ + D L+ +NID Sbjct: 180 LRDLHNLSDLSIFIKSLMIEKNKLQKKLKKSVPIFLKLSPDIEKSKIKPIIDLLIANNID 239 Query: 241 GVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDS 300 GVI TNTT+D+S + GG+SG PL++KS +++ + +L II VGGI + Sbjct: 240 GVIVTNTTIDKSKISK-PYQHLPGGVSGAPLKIKSEQMLSTVKKISKNKLLIISVGGIMT 298 Query: 301 VIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 A ++I GA LVQIY+G I++GP L+ EI + Sbjct: 299 ADDALKRIRMGADLVQIYTGLIYQGPSLVNEIRQKL 334 >UniRef50_B3CMR9 Dihydroorotate dehydrogenase n=10 Tax=Rickettsiales RepID=B3CMR9_WOLPP Length = 355 Score = 324 bits (831), Expect = 3e-87, Method: Composition-based stats. Identities = 127/336 (37%), Positives = 194/336 (57%), Gaps = 14/336 (4%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLA 61 Y +R LF L PE AH L+++ L + VN G ++P+GLA Sbjct: 13 YKMILRNLLFLLPPEIAHSLVITALKKMPCRKPIEL----PKSLNVNFFGNKIRSPVGLA 68 Query: 62 AGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVD 121 AG DK+ E + + + GFG IE GTVT PQ GN KPR+FRL+ EG+INR+GFNN GVD Sbjct: 69 AGFDKNAEVVKPMLSFGFGFIEAGTVTKHPQYGNKKPRIFRLIKDEGIINRLGFNNKGVD 128 Query: 122 NLVENVKKAHY-DGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPG 180 ++ + + + + GINIG+N + + DY+ ++ +Y + YI +NISSPNTP Sbjct: 129 YFLKQISETKLGNCIFGINIGRNSTS--KDQISDYVDLIKIVYGKSNYIVLNISSPNTPN 186 Query: 181 LRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNID 240 LR L + L LL +I + + + +PI +KI+PD+ ++ +A+ + + ID Sbjct: 187 LRDLHNKQELSKLLKSITLTRKSID--SSESIPIILKISPDIDQQTKENIAELTLEYKID 244 Query: 241 GVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDS 300 G+I +NTT+ R +++GGLSGRPL STE++ + R+ +IG GGI S Sbjct: 245 GLIVSNTTISRDSY-----YNESGGLSGRPLFQLSTELLSDMYKLTKSRILLIGCGGISS 299 Query: 301 VIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + A EKI AGASLVQ+Y+ +++G ++ +I + Sbjct: 300 GVDAYEKIKAGASLVQLYTALVYQGHQVVNKINLEL 335 >UniRef50_Q0J918 Os04g0676300 protein n=1 Tax=Oryza sativa Japonica Group RepID=Q0J918_ORYSJ Length = 601 Score = 322 bits (825), Expect = 1e-86, Method: Composition-based stats. Identities = 128/358 (35%), Positives = 187/358 (52%), Gaps = 31/358 (8%) Query: 4 PFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAAG 63 V LD E AH R + G F NP+GLAAG Sbjct: 179 QLVNPLFALLDAEFAHRLAVTAASHG---FVPREKRPDPSVLGLEIWGRKFTNPIGLAAG 235 Query: 64 LDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNL 123 DK+ E ++ L MGFG +E+G+VTP PQ GN KPR+FRL + +INR GFN+ G+ + Sbjct: 236 FDKNAEAVEGLLGMGFGFVEVGSVTPLPQEGNPKPRIFRLREHGAVINRCGFNSEGIVVV 295 Query: 124 VENVKKAHYD-------------------------GVLGINIGKNKDTPVEQGKDDYLIC 158 + + H G+LG+N+GKNK + E DY+ Sbjct: 296 AKRLGAQHGKRKMEETSSSTSPTTSDVKQGGKAGPGILGVNLGKNKIS--EDATADYVQG 353 Query: 159 MEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKI 218 + + YA Y+ IN+SSPNTPGLR LQ + L DL+ ++ ++++Q P+ VKI Sbjct: 354 VHTLSQYADYLVINVSSPNTPGLRKLQGRKQLKDLVKKVQAARDEMQWAEDGPPPLLVKI 413 Query: 219 APDLSEEELIQVADSLVRHNIDGVIATNTTLDRSL-VQGMKNCDQTGGLSGRPLQLKSTE 277 APDLS+++L +A + +DG+I +NTT+ R + GGLSG+PL ST Sbjct: 414 APDLSKQDLEDIAAVALALRLDGLIISNTTISRPSPADTHPLAQEAGGLSGKPLFDLSTN 473 Query: 278 IIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTH 335 ++R + + G++P+IG GG+ S A +KI +GA+LVQ+Y+ F + GP LI I Sbjct: 474 VLREMYILTRGKIPLIGCGGVSSGEDAYKKIRSGATLVQLYTAFAYGGPALIPRIKKA 531 >UniRef50_A8WW30 C. briggsae CBR-DHOD-1 protein n=3 Tax=Caenorhabditis RepID=A8WW30_CAEBR Length = 426 Score = 321 bits (824), Expect = 2e-86, Method: Composition-based stats. Identities = 140/360 (38%), Positives = 201/360 (55%), Gaps = 30/360 (8%) Query: 2 YYPFVRKALFQ-LDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 Y V + + +D E +H + + F R++ P G F+NP+GL Sbjct: 47 YKKAVMPMVHKFVDGEDSHRWAVRAASWGLLPRFGW-NRKEYPELKCELFGREFRNPIGL 105 Query: 61 AAGLDKDGECIDALGA-MGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLG 119 AAG DKDG+ I L GFG IEIG+VTP PQPGN++PR+FRL++ EG+INR GFN+ G Sbjct: 106 AAGFDKDGQAITQLAKNSGFGLIEIGSVTPIPQPGNNRPRVFRLLEDEGVINRYGFNSDG 165 Query: 120 VDNLVENVKKAHYDGV------LGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINI 173 V + + V+ A V G+N+GKNK T E K DY I + + Y+ +N+ Sbjct: 166 VGRVHQRVRSARDAWVPEQYAYFGVNLGKNKLT--EDAKLDYEIGVNYFAPHCDYLVLNV 223 Query: 174 SSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADS 233 SSPNTPGLR++Q L+ LL +K + + K I +KIAPDL + E+ +A Sbjct: 224 SSPNTPGLRSMQKKSDLEKLLAYVKESLDMHK--LEKRPQIFLKIAPDLIDSEMKDIAHV 281 Query: 234 L--VRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLP 291 + + +DG+I +NTT+ R +N +TGGLSG P++ STE IR++ NG++P Sbjct: 282 VTNKKFGVDGIIVSNTTIARPDYLKSENKAETGGLSGAPVREISTECIRKMYKLTNGQIP 341 Query: 292 IIGVGGIDSVIAAREKIA---------------AGASLVQIYSGFIFKGPPLIKEIVTHI 336 IIG GG+ S A EKI AG SLVQ+YS F+++G P+I +I + Sbjct: 342 IIGCGGVFSGEDAYEKIRYNRRNAIDSNYNIFSAGGSLVQLYSAFVYEGFPVIGKIKREL 401 >UniRef50_Q056I9 Dihydroorotate dehydrogenase n=6 Tax=Leptospira RepID=Q056I9_LEPBL Length = 384 Score = 321 bits (823), Expect = 2e-86, Method: Composition-based stats. Identities = 143/340 (42%), Positives = 196/340 (57%), Gaps = 10/340 (2%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGTP-----FEALVRQKVPAKPVNCMGLTFKN 56 Y F++ LDPE +HE L P E++ + G+ F+N Sbjct: 21 YSTFLKPFFLSLDPETSHELAKNLLSISAKFPGILTLVESMTSYRSDRLKTRVAGIEFEN 80 Query: 57 PLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFN 116 PLG+ AG DK GE L MGFG IEIGT+T + QPGN KPR+FR + + LIN MGFN Sbjct: 81 PLGMGAGFDKTGELYPFLSRMGFGHIEIGTITGKSQPGNLKPRVFRYPEDQALINHMGFN 140 Query: 117 NLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSP 176 N G D+ + + GIN GK K E+ +DY+ ++K+ YA Y INISSP Sbjct: 141 NPGADSAERIIAPQKKRKIRGINAGKTKIISEEKAVEDYIYTLKKLSPYADYAVINISSP 200 Query: 177 NTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVR 236 NTPGLR Q + L+ IKN + +P+ VK APD+ ++L + +S + Sbjct: 201 NTPGLRDFQKQKNFVSLIQGIKNGLGK-----NFIIPLFVKFAPDMETKDLEALLESSLS 255 Query: 237 HNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVG 296 IDGV+ TNTT+D+S ++ N ++ GGLSG PL+ +STE +R L R+PIIGVG Sbjct: 256 LKIDGVVLTNTTIDKSSLKAYPNVEKEGGLSGVPLKNRSTEFVRVAYRILKRRIPIIGVG 315 Query: 297 GIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 GIDS AA EKI AGA L+QIY+G+I++GP L +I+ + Sbjct: 316 GIDSEKAALEKILAGADLIQIYTGYIYQGPFLPLKILEFL 355 >UniRef50_C6NV76 Dihydroorotate dehydrogenase n=1 Tax=Acidithiobacillus caldus ATCC 51756 RepID=C6NV76_9GAMM Length = 367 Score = 321 bits (822), Expect = 3e-86, Method: Composition-based stats. Identities = 136/337 (40%), Positives = 195/337 (57%), Gaps = 13/337 (3%) Query: 7 RKALFQLDPERAHEFTFQQLRRITGTP----FEALVRQKVPAKPVNCMGLTFKNPLGLAA 62 R LF L+PE AH + + L + P R P GL F +P+GLAA Sbjct: 9 RPWLFLLEPEHAHALSLRVLGGLNEMPKTRAHLWPHRPSDPRLAQELWGLHFAHPVGLAA 68 Query: 63 GLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDN 122 G DKDG+ + +L ++GF +E+GTVTPRPQPGN PR+FR +INR+GF + G Sbjct: 69 GFDKDGQALKSLASVGFAFLELGTVTPRPQPGNPGPRIFRYPQQRAVINRLGFPSQGGSA 128 Query: 123 LVENVKK-AHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGL 181 + + + LGINIGKN++TP+ DY ++++ +A YI+IN+SSPNTP L Sbjct: 129 VADRLAATLPLTVPLGINIGKNRETPLTAAVGDYRALIQQLGPFADYISINVSSPNTPEL 188 Query: 182 RTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHN--I 239 R LQ ++L LL ++ + LQ P+ +KIAPDL+ +E+ +A + Sbjct: 189 RRLQDPQSLRPLLQELREARQKLQR----QPPLLLKIAPDLAPDEVTALAALAQEPQPLL 244 Query: 240 DGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGID 299 DG IATNTTL R + GGLSG PL+ ++ II +L +GRLPIIGVGG+ Sbjct: 245 DGFIATNTTLGRPSDWPHPA--EAGGLSGAPLKRRANGIIAQLYRASSGRLPIIGVGGVA 302 Query: 300 SVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + +KI AGASLVQ+Y+ I++GP L+++I + Sbjct: 303 TAQDVLDKIEAGASLVQLYTALIYEGPDLVQQITDAL 339 >UniRef50_B0CUF5 Predicted protein n=4 Tax=Dikarya RepID=B0CUF5_LACBS Length = 499 Score = 320 bits (821), Expect = 4e-86, Method: Composition-based stats. Identities = 125/350 (35%), Positives = 187/350 (53%), Gaps = 20/350 (5%) Query: 1 MYYPFVRKAL-FQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLG 59 ++ L F LD E H+F + LR P + ++ G NP+G Sbjct: 67 LHRYIFTPILRFALDAETGHKFAVKVLRSGLA-PKDPVL--DDARLNCQIWGQEASNPVG 123 Query: 60 LAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLG 119 LAAG DKDGE ID L +GF +EIG+VTP+PQPGN +PR+F L + LINR GF + G Sbjct: 124 LAAGFDKDGEAIDGLFELGFSWVEIGSVTPKPQPGNPRPRVFHLPEDSSLINRYGFPSQG 183 Query: 120 VDNLVENVKKA-------------HYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYA 166 +++ ++ +L +N+GKNK++P DD++ + Y+ Sbjct: 184 HASVLSRIRSRIPPFTSGPNRASLREGCLLAVNLGKNKESP-ADSIDDFVTGVRTFGPYS 242 Query: 167 GYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQ--AMHHKYVPIAVKIAPDLSE 224 + +N+SSPNTPGLR LQ + L+ LL + +++L + + + +K APDL+E Sbjct: 243 DVLVVNVSSPNTPGLRGLQNRDVLERLLDGVTKARDELSPSVLTFRKPKLVLKFAPDLNE 302 Query: 225 EELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSL 284 EL +AD + +IDGVI +NTT+ R N + GGLSG P++ S + +R L Sbjct: 303 SELADIADVIRNSSIDGVIVSNTTVQRPKSLVNPNKSEMGGLSGPPVKPLSLKALRILRG 362 Query: 285 ELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVT 334 L +P+IG GGI + A E AGAS+VQ+Y+GF + G + I Sbjct: 363 HLPASIPLIGCGGISTGADALEFAKAGASMVQVYTGFGYDGVGACRRIKD 412 >UniRef50_B3DX48 Dihydroorotate dehydrogenase n=1 Tax=Methylacidiphilum infernorum V4 RepID=PYRD_METI4 Length = 348 Score = 320 bits (821), Expect = 4e-86, Method: Composition-based stats. Identities = 129/343 (37%), Positives = 180/343 (52%), Gaps = 19/343 (5%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEAL---VRQKVPAKPVNCMGLTFKNP 57 +Y F+R LF L+PE AH L F L ++ +P P G+ F NP Sbjct: 2 IYKSFLRPILFSLEPEYAHNLCLGLLSHPFYPFFHKLLASFQKDLPLLPKELWGMQFPNP 61 Query: 58 LGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNN 117 +GLAAG DK+G + A + GFG +EIGTVTP PQ GN PRL RL L N +GF + Sbjct: 62 VGLAAGFDKNGVGLRAWESFGFGFVEIGTVTPLPQEGNPAPRLCRLPKEGALWNSLGFPS 121 Query: 118 LGVDNLVENVKKA----HYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINI 173 G + E +KK +GINIGKN+ TP+E+ +DY C + +N+ Sbjct: 122 QGAQRVAERLKKVFLSGRPKIPVGINIGKNRHTPLEETIEDYKKCFSYFKDLGDFFVVNV 181 Query: 174 SSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADS 233 SSPNTPGL++LQ L+ L + P+ VKIAPD+ + L + + Sbjct: 182 SSPNTPGLKSLQQKRFLELLFDRLNPLN------SSPRKPLLVKIAPDIELKNLAGILEV 235 Query: 234 LVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPII 293 L+R+ G++ NT + GGLSG+PL+ S +IR + E GRLPII Sbjct: 236 LLRNESVGIVIANTLPA------KGPGGKEGGLSGKPLRELSLGLIRFVKKETAGRLPII 289 Query: 294 GVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 GVGGI S A EK+ AGA L++I++GF++ GP + + Sbjct: 290 GVGGIFSSKDAFEKMEAGADLIEIFTGFVYNGPSFPANLCREL 332 >UniRef50_B0MVX7 Putative uncharacterized protein n=1 Tax=Alistipes putredinis DSM 17216 RepID=B0MVX7_9BACT Length = 356 Score = 320 bits (820), Expect = 5e-86, Method: Composition-based stats. Identities = 127/344 (36%), Positives = 188/344 (54%), Gaps = 12/344 (3%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTP-----FEALVRQKVPAKPVNCMGLTFK 55 MY ++ LF ++ ERAH LR I P A+ R + P+ GL F Sbjct: 1 MYRKLIKPILFAMNIERAHSTVLFLLRMIGKIPGGRALLRAMYRTEHPSLEREVFGLRFP 60 Query: 56 NPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGF 115 NP+GLAAG D++GE L A+GFG +EIGTVTP+PQ GN +PR+FRL +INR G Sbjct: 61 NPIGLAAGFDRNGEAFRELSALGFGFVEIGTVTPQPQAGNPRPRIFRLPADRAIINRSGL 120 Query: 116 NNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISS 175 NN G+ + ++ H ++G NIGKN T Q DYL +Y Y Y +IN+ Sbjct: 121 NNKGLYKAIAQLRHRHDRLIIGGNIGKNTLTQPSQVAADYLKMFRNLYQYVDYFSINVCC 180 Query: 176 PNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLV 235 N L ++L + D + ++Y PI +KI+PDL + + +V D ++ Sbjct: 181 DNCADGSVSHNKAHLMNILQPL----FDFRRGQNQYRPILLKISPDLPDPLIDEVTDLML 236 Query: 236 RHNIDGVIATNTTLDRSL---VQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPI 292 +DG++A N T R + + +G LSG PL ++ E++RR+ +G PI Sbjct: 237 STPLDGIVAVNGTFSRKGLETDEETLDEIGSGRLSGAPLTQRAIEVVRRIHRRSHGAYPI 296 Query: 293 IGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 IGVGG+ + + +AAGASLVQ+Y+G+I++GP L+KEI + Sbjct: 297 IGVGGLMNARDVKAMLAAGASLVQLYTGYIYEGPSLVKEICRAL 340 >UniRef50_B6R4R9 Dihydroorotate oxidase n=1 Tax=Pseudovibrio sp. JE062 RepID=B6R4R9_9RHOB Length = 367 Score = 320 bits (820), Expect = 5e-86, Method: Composition-based stats. Identities = 138/331 (41%), Positives = 204/331 (61%), Gaps = 7/331 (2%) Query: 8 KALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKD 67 +AL LDPE +H T + L + + A LTFKNP+G+AAG DK+ Sbjct: 13 RALHCLDPETSHNATIKMLASGLAP---TFGQVENKALEYKLGDLTFKNPVGMAAGFDKN 69 Query: 68 GECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENV 127 E I L +GFG +E+GTVTP PQ GN KPR FRL +INR GFNN G D + E + Sbjct: 70 AEAITPLMKLGFGHVEVGTVTPLPQEGNPKPRNFRLSADRAVINRYGFNNDGHDVVYERI 129 Query: 128 KKA-HYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQY 186 +KA GVLGIN+G NK + E DY++ +++ A Y+ NISSPNTPGLR LQ Sbjct: 130 RKAGRTPGVLGINVGANKLS--EDRVADYVLGVKRFAELADYLTANISSPNTPGLRDLQE 187 Query: 187 GEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATN 246 +AL LL+AI N +++ + + VP+ +KIAPD++EE L ++A+ ++ + +DG+I +N Sbjct: 188 KDALAHLLSAIVNARDEQEDRLGRKVPVMLKIAPDVTEEALKEIAEVVMTNKVDGMIVSN 247 Query: 247 TTLDRS-LVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAR 305 TT+ R ++ + ++ GGLSG PL ++T + + + LP+ GVGG+D+ A Sbjct: 248 TTIARPSTLKDQQQAEEAGGLSGAPLFERATIALAKTRRAVGPDLPLFGVGGVDTPEKAA 307 Query: 306 EKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 KI AGA+ +Q+YSG +++G L+K+I H+ Sbjct: 308 AKIFAGANQIQLYSGMVYEGQTLVKKINKHL 338 >UniRef50_A5EA61 Dihydroorotate dehydrogenase n=122 Tax=cellular organisms RepID=PYRD_BRASB Length = 364 Score = 318 bits (814), Expect = 2e-85, Method: Composition-based stats. Identities = 137/337 (40%), Positives = 191/337 (56%), Gaps = 9/337 (2%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLA 61 + L LD E AH Q L+ + V GL F NP+G+A Sbjct: 5 FDQLSLPLLRWLDAEDAHRLAIQGLKLLPAIKPRP----DDAKLAVRAFGLNFPNPVGMA 60 Query: 62 AGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVD 121 AG DK+ E DAL +GFG +EIG+VTPRPQ GN +PRLFRL E ++NRMGFNN G + Sbjct: 61 AGFDKNAEVPDALLRLGFGFVEIGSVTPRPQSGNPRPRLFRLERDEAVVNRMGFNNDGAE 120 Query: 122 NLVENVK-KAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPG 180 ++ + +A+ G++G+N+G NKD+ DY+ +E A Y +NISSPNTPG Sbjct: 121 IVLRRLAGRANQGGIVGVNVGANKDS--ADRVADYVRLIETFAPVASYFTVNISSPNTPG 178 Query: 181 LRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNID 240 LR LQ L++LL+ + ++ ++ P+ +KIAPDLS EL V +D Sbjct: 179 LRNLQQAAQLNELLSKVLEARDRVRRKAG-DTPVLLKIAPDLSLAELDDVVHVARSRGVD 237 Query: 241 GVIATNTTLDRS-LVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGID 299 G+I +NTTL R ++ + GGLSGRPL ST ++ + + G P+IGVGGID Sbjct: 238 GMIVSNTTLARPNSLREQLRAKEQGGLSGRPLFRLSTRMVAETFVRVEGAFPLIGVGGID 297 Query: 300 SVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 S AA KI AGASL+Q+YS ++KG L++ I + Sbjct: 298 SGGAALTKIRAGASLIQLYSSLVYKGLGLVESIKADL 334 >UniRef50_Q1GGD3 Dihydroorotate oxidase A n=18 Tax=Alphaproteobacteria RepID=Q1GGD3_SILST Length = 352 Score = 316 bits (810), Expect = 8e-85, Method: Composition-based stats. Identities = 134/334 (40%), Positives = 188/334 (56%), Gaps = 10/334 (2%) Query: 3 YPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAA 62 + +LDPE AH + + LR + P + GL+ NP+GLAA Sbjct: 5 EKLALGLMHRLDPETAHGLSIKALRAGLTPRPGPV---TSPRLRTDVAGLSLPNPVGLAA 61 Query: 63 GLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDN 122 G DK+ E + L GFG IE+G TPRPQPGN KPRLFRL + INR GFNN G+D Sbjct: 62 GFDKNAEALAPLSEAGFGFIEVGAATPRPQPGNPKPRLFRLSEDRAAINRFGFNNEGMDT 121 Query: 123 LVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLR 182 + + + + GV+G+N+G NKD+ E D+ + A+ + +N+SSPNT LR Sbjct: 122 IGKRLAQRPKSGVIGLNLGANKDS--EDRAQDFARVLSHCGAHLDFATVNVSSPNTEKLR 179 Query: 183 TLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGV 242 LQ +AL LL + + + LQ +P+ +KIAPDL L +A+ ID V Sbjct: 180 DLQGKDALASLLAGVIDAREALQR----PIPVFLKIAPDLDISGLDDIAEVARDSGIDAV 235 Query: 243 IATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVI 302 IATNTTL R ++ + D+ GGLSG PL +ST ++ +LS L+G +PIIGVGGI + Sbjct: 236 IATNTTLSRDGLKST-HRDEMGGLSGAPLFERSTRVLAQLSQRLDGAVPIIGVGGISTAE 294 Query: 303 AAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 A KI AGAS VQ+Y+ ++ G L E+ + + Sbjct: 295 GAYAKIRAGASAVQLYTALVYGGLSLASEVASGL 328 >UniRef50_B9L4A8 Dihydroorotate oxidase n=2 Tax=Thermomicrobia (class) RepID=B9L4A8_THERP Length = 374 Score = 315 bits (808), Expect = 1e-84, Method: Composition-based stats. Identities = 128/343 (37%), Positives = 190/343 (55%), Gaps = 8/343 (2%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTP-----FEALVR-QKVPAKPVNCMGLTF 54 Y V LF+LDPE AH L R++ P + R V LTF Sbjct: 15 WYRRIVTPLLFRLDPEDAHRLVLGVLSRLSRCPGSERVLRRVFRVPDDERLRVEVGDLTF 74 Query: 55 KNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMG 114 NP+GLAAG+DK+ E + A +GFGS+E+GTVTP PQ GN +PRL+R + E L+N +G Sbjct: 75 PNPIGLAAGVDKNAEAVAAWFGLGFGSVEVGTVTPCPQEGNPRPRLWRFPEDETLVNALG 134 Query: 115 FNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINIS 174 F + GV + + + G +GIN+GKN TP+EQ DY + ++ A Y+ +N+S Sbjct: 135 FPSDGVAAVRARLVGRWFPGPVGINLGKNAWTPLEQAVVDYCATLVALWDVADYVVVNVS 194 Query: 175 SPNTPGLRTLQYGEALDDLLTAIKNKQNDLQA-MHHKYVPIAVKIAPDLSEEELIQVADS 233 SPNTPGLR LQ GE L+ +L A++ L A + P+ VK++ DL L + Sbjct: 195 SPNTPGLRELQRGERLEQVLAAVQETNRTLAALQRARPRPLFVKVSLDLDAGALADAIEI 254 Query: 234 LVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPII 293 V DG+I NT++D S ++ GG+SGRPL+ ++ E++ + GRL +I Sbjct: 255 AVAVGADGLILGNTSIDPS-LRPAGAGALPGGVSGRPLRKRAVELLSNAADRAGGRLALI 313 Query: 294 GVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 VGG+ +++ GA LVQ+Y+G +F+GP L ++ + Sbjct: 314 SVGGVLETDDVIQRLRLGADLVQVYTGLVFRGPALPAVLLRGL 356 >UniRef50_Q83GM4 Dihydroorotate oxidase n=2 Tax=Tropheryma whipplei RepID=Q83GM4_TROWT Length = 335 Score = 315 bits (807), Expect = 2e-84, Method: Composition-based stats. Identities = 121/340 (35%), Positives = 181/340 (53%), Gaps = 15/340 (4%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLA 61 Y + L +DPE AH L+ G MGL F PLG+A Sbjct: 1 MYSYFLNFLKCVDPELAHRIAAVALKSGLGMFVPQRFHIH---LGTTSMGLYFDTPLGIA 57 Query: 62 AGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVD 121 AG DK + + L ++GFG +E+GTVT PQPGN KPR+ R++ + LIN MGFNN G Sbjct: 58 AGFDKFADLVIPLYSLGFGHVEVGTVTLHPQPGNKKPRIHRVMSQKALINSMGFNNPGAQ 117 Query: 122 NLVENVKKAHYDG----VLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPN 177 + EN+ K G ++G+NIGK+K P+E+ DY+ E + + Y+ IN+SSPN Sbjct: 118 KMRENILKVRKSGRRLPIIGVNIGKSKVCPLEESAKDYVKSFELLADVSDYLVINVSSPN 177 Query: 178 TPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRH 237 T GLRTLQ L+ +L ++K + + P+ +KI+PDLS ++ +A + Sbjct: 178 TEGLRTLQSVGNLNKILRSVKPIADRFKR------PVLIKISPDLSNSDVTNIALLVKEF 231 Query: 238 NIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELN-GRLPIIGVG 296 + GV+A+NTT R+ + + GGLSG L+ +S E+++ L +L + II VG Sbjct: 232 GLAGVVASNTTTKRTGL-PNEFSSLHGGLSGPMLKERSLEMLKILRRDLPKNKFCIISVG 290 Query: 297 GIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 G+ E++ GA LVQ Y+ F++ GP I + Sbjct: 291 GVWDYTDVLERLEYGADLVQGYTAFVYNGPYWASNINRDL 330 >UniRef50_B7G8S8 Predicted protein n=2 Tax=Bacillariophyta RepID=B7G8S8_PHATR Length = 456 Score = 314 bits (806), Expect = 2e-84, Method: Composition-based stats. Identities = 143/362 (39%), Positives = 203/362 (56%), Gaps = 32/362 (8%) Query: 1 MYYPFVRKALFQ-LDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLG 59 + V + + LDPE AH + F ++ + G TF NP+G Sbjct: 46 LVDHIVTPTMRRILDPETAHHAGIFFAEQGLSPRFRPSALEQRCVVSNSVFGKTFPNPIG 105 Query: 60 LAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLG 119 LAAG DKDGE + + +GFG +EIGTVTP+ QPGN KPR+FRLV+ G+INR GFN+ G Sbjct: 106 LAAGFDKDGEVVQEMLDLGFGFVEIGTVTPQAQPGNPKPRMFRLVEDLGIINRYGFNSQG 165 Query: 120 VDNLVENVKKAHYDGVL-------------------------GINIGKNKDTPVEQGKDD 154 + +N+K + G+NIGKNK++ D Sbjct: 166 ASTVEKNLKSFRSPQPIDSAKLSWPRYIWNFLYPPRHQSGLVGVNIGKNKNSL--DAIGD 223 Query: 155 YLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPI 214 Y+ + ++ + A Y+ +NISSPNT GLR LQ +L LLT +N++ VP+ Sbjct: 224 YVCNIRQLSSLADYMVLNISSPNTAGLRDLQQANSLRVLLTTCLTTRNEM----THRVPL 279 Query: 215 AVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLK 274 VK+APDL++EEL Q+A+ + IDG+I TNTT R K+ + GGLSG+P++ + Sbjct: 280 LVKLAPDLTDEELDQIANVCLEVGIDGIIITNTTNHRPADLLSKHRGEIGGLSGKPVKDQ 339 Query: 275 STEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVT 334 STE IRRL +G++PIIGVGG+ S A EK+ AGASLVQ+YS +++GP +I I Sbjct: 340 STECIRRLFRLTDGKIPIIGVGGVGSGHDAYEKLKAGASLVQVYSMMVYQGPGVISRIRH 399 Query: 335 HI 336 + Sbjct: 400 DL 401 >UniRef50_Q47RF2 Dihydroorotate dehydrogenase n=52 Tax=Bacteria RepID=PYRD_THEFY Length = 377 Score = 314 bits (804), Expect = 3e-84, Method: Composition-based stats. Identities = 138/348 (39%), Positives = 194/348 (55%), Gaps = 15/348 (4%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTP-----FEALVRQKVPAKPVNCMGLTFK 55 +Y L ++D ERAH +F LR + P ++ + P V G F Sbjct: 2 LYQFIFHTLLRRVDAERAHRVSFAGLRALAAVPGTTRLMRRVLGPREPELRVRVFGREFP 61 Query: 56 NPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGF 115 PLGLAAG DK+ + AL A+GF +EIGTVT +PQPGN +PRLFRLV ++NRMGF Sbjct: 62 GPLGLAAGFDKNARGVAALTALGFSHVEIGTVTGQPQPGNPRPRLFRLVADRAIVNRMGF 121 Query: 116 NNLGVDNLVE----NVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAI 171 NN G + E + + D ++G+NIGK K P DY+ + A Y+ + Sbjct: 122 NNEGSQAVSERLRAHRARRARDLIVGVNIGKTKVVPDSDAVADYVTSARRFADLADYLVV 181 Query: 172 NISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVA 231 N+SSPNTPGLR LQ E L LL+A++ + +P+ VKIAPDL++E++ VA Sbjct: 182 NVSSPNTPGLRDLQATERLRPLLSAVRRTLD---EAGRPDLPLLVKIAPDLADEDIDAVA 238 Query: 232 DSLVRHNIDGVIATNTTLDRSL---VQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNG 288 D V +DG+IATNTT+ R GGLSG PL+ ++ +++RRL + Sbjct: 239 DLAVELGLDGIIATNTTVSRDGLATDPEEVAALGAGGLSGAPLKERALQVLRRLRARVGD 298 Query: 289 RLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 RL +I VGGI++ A +I AGA+LVQ Y+G I+ GP + I + Sbjct: 299 RLVLIAVGGIETPEDAWARIRAGATLVQGYTGLIYGGPLWPRRIHRGV 346 >UniRef50_Q30R79 Dihydroorotate dehydrogenase n=10 Tax=Campylobacterales RepID=PYRD_SULDN Length = 352 Score = 314 bits (804), Expect = 3e-84, Method: Composition-based stats. Identities = 143/340 (42%), Positives = 190/340 (55%), Gaps = 18/340 (5%) Query: 3 YPFVRKALFQLDPERAHEFTFQQLRRITGT-----PFEALVRQKVPAKPVNCMGLTFKNP 57 Y ++ LF+L+PE AH LR PF G TF NP Sbjct: 4 YQSIKPWLFKLEPEDAHMLAEAALRIPNVCQVAFNPFLESHFITNSILKQELFGRTFFNP 63 Query: 58 LGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNN 117 +GL AG DK+ I A+ +GFG EIGT+TP+ Q GN KPR+FR ++ + + N MGFNN Sbjct: 64 IGLGAGFDKNATMIRAMQILGFGFTEIGTITPKAQAGNPKPRMFRHIEEQSIQNAMGFNN 123 Query: 118 LGVDNLVENVKKA-HYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSP 176 G+ + + +KK + +GINIGKNK TP Q +DY ++ ++ Y+ INISSP Sbjct: 124 EGLLSAQKRLKKRFPFTTPIGINIGKNKLTPDTQAINDYTTLIKALHELGDYLVINISSP 183 Query: 177 NTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVR 236 NTPGLR LQ E + L K PI +KIAPD+S+E+ + + V Sbjct: 184 NTPGLRDLQNEEFITKLFEESKAIT---------SKPILLKIAPDMSKEDAVALTKLAVL 234 Query: 237 HNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVG 296 DG+IATNTT+D SLV+ K+ GGLSG L+ KS EI ++ EL G+ +I VG Sbjct: 235 KGADGIIATNTTVDYSLVKEPKS---IGGLSGAVLKEKSFEIFEAVAKELYGKTTLISVG 291 Query: 297 GIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 GI S +I AGASLVQIYSG I++GP LIK I + Sbjct: 292 GISSAKEVYRRIKAGASLVQIYSGLIYEGPDLIKNINNEL 331 >UniRef50_B1ZSY3 Dihydroorotate oxidase n=3 Tax=Verrucomicrobia RepID=B1ZSY3_OPITP Length = 352 Score = 313 bits (802), Expect = 6e-84, Method: Composition-based stats. Identities = 145/336 (43%), Positives = 199/336 (59%), Gaps = 16/336 (4%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGT-PFEALVRQK-----VPAKPVNCMGLTFK 55 Y +R LF++DPE+AHE L + P L+ + +PV GL F Sbjct: 5 YERAIRPVLFRMDPEKAHELAVHGLTLLAKLQPVCRLLEWQHRLPADCRRPVRAFGLDFP 64 Query: 56 NPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGF 115 N +GLAAG DK+ AL A+GFG +EIGT+T QPGN+KPR+FR + +INRMGF Sbjct: 65 NAIGLAAGFDKNATAWPALAALGFGHVEIGTITALAQPGNEKPRVFRFPAEKAVINRMGF 124 Query: 116 NNLGVDNLVENVKKAH----YDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAI 171 NN G + + + LGIN+GK+K T ++Q DYL ++ +A YIA+ Sbjct: 125 NNEGSEAIARRLAHQPGVGQRRIPLGINLGKSKVTDLDQAAQDYLTSFGRLADHADYIAL 184 Query: 172 NISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVA 231 N+SSPNTPGLR LQ + +LL AI + VP+ +KIAPDL+ ++ V Sbjct: 185 NVSSPNTPGLRQLQDEARVRELLGAISAA----NRARPRPVPLLLKIAPDLTFPQIDAVL 240 Query: 232 DSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLP 291 +L+ DG+IATNTTL R +Q GGLSGRPL+ +STEII ++ G+LP Sbjct: 241 AALMEFRFDGIIATNTTLARPG--PFAAANQAGGLSGRPLRRRSTEIINYIARATAGKLP 298 Query: 292 IIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPP 327 IIGVGGI+ +A EK+ AGA+L+QIY+G I++GP Sbjct: 299 IIGVGGIEDGASAAEKLDAGATLLQIYTGMIYRGPW 334 >UniRef50_Q0GF37 Dihydroorotate dehydrogenase n=2 Tax=Ustilago maydis RepID=Q0GF37_USTMA Length = 677 Score = 312 bits (799), Expect = 1e-83, Method: Composition-based stats. Identities = 134/397 (33%), Positives = 197/397 (49%), Gaps = 65/397 (16%) Query: 1 MYYPFVRKALFQ-LDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLG 59 ++ AL LDPE A + + L + G NP+G Sbjct: 98 IHRWIAVPALKAFLDPESAQKLAVKMLETGLAP---RDLVDDDAVLETELFGRKLSNPIG 154 Query: 60 LAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLG 119 LAAG DK E ID L +GFG IEIG+VTP PQPGN +PR FRL++ INR GFN+ G Sbjct: 155 LAAGFDKQAEAIDGLLDLGFGFIEIGSVTPEPQPGNPQPRYFRLIEDNACINRFGFNSEG 214 Query: 120 VDNLVENVKKA------------------------------------------------- 130 + ++ ++ Sbjct: 215 HNVILSRLRDRIRRWLLHSSSVANLQDALLASPDSASVNARQLIATHPKSTSAFVDATDL 274 Query: 131 ----HYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQY 186 +LGIN+GKNK T E+ DDY+ +E++ YA I +N+SSPNTPGLR LQ Sbjct: 275 PRSLRPAKMLGINLGKNK-TSNEESVDDYVKGVERLGPYADMIIVNVSSPNTPGLRRLQR 333 Query: 187 GEALDDLLTAIKNKQNDLQAMHHK------YVPIAVKIAPDLSEEELIQVADSLVRHNID 240 L+DLLT + ++ + H + VP+ VKIAPDLSEEEL VAD+ ++ ID Sbjct: 334 RGVLEDLLTQVVRARDGMVESHLRFSDKKVAVPLLVKIAPDLSEEELHDVADAALKSGID 393 Query: 241 GVIATNTTLDRSL-VQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGID 299 G++ +NTT+ R ++ ++ +TGGLSG P++ + + + + L G+LPIIG GGI Sbjct: 394 GLVISNTTISRPASLRSSEHVRETGGLSGAPVKPLALKALTTVHKRLQGKLPIIGCGGIS 453 Query: 300 SVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + A + AGAS +++Y+ F ++G L + + + Sbjct: 454 NGQDALDYAKAGASAIELYTSFGYQGVGLPRRLKDEL 490 >UniRef50_Q75CE1 Dihydroorotate dehydrogenase, mitochondrial n=9 Tax=Saccharomycetales RepID=PYRD_ASHGO Length = 444 Score = 310 bits (794), Expect = 5e-83, Method: Composition-based stats. Identities = 138/362 (38%), Positives = 191/362 (52%), Gaps = 36/362 (9%) Query: 4 PFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAAG 63 P VR L D E H+ L+ + + P V G T NP+G AAG Sbjct: 70 PLVR--LVTPDAEDGHKLGIWFLKYGLAPKL--MFDKDDPVLKVEVFGKTMSNPIGCAAG 125 Query: 64 LDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV--- 120 LDKDGE ID + GFG +EIGTVTP QPGN KPR FRL E +INR GFN+ G Sbjct: 126 LDKDGEAIDGIAQSGFGYVEIGTVTPLAQPGNPKPRFFRLPMDEAVINRYGFNSSGHKKV 185 Query: 121 -DNLVENVKK---------------AHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYA 164 DN++ V++ + D +LGIN+GKNK+ +DYL +EK + Sbjct: 186 YDNVLSRVRQFLGAYFRDDTVNSLALYKDKLLGINLGKNKN---GDEVEDYLRGVEKFQS 242 Query: 165 YAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQND------LQAMHHKYVPIAVKI 218 A + IN+SSPNTPGLR LQ L +LL+ I K+N + P+ VKI Sbjct: 243 LADVLVINVSSPNTPGLRDLQQEGRLTELLSMIVAKRNSLINEGNVLGASTHKPPVLVKI 302 Query: 219 APDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQ---GMKNCDQTGGLSGRPLQLKS 275 APDL+E EL +A++ + +IDG+I +NTT+ R + +Q GGLSG+P++ + Sbjct: 303 APDLTEPELQSIAEAAKKSSIDGIIVSNTTIQRPDSLYTVDEELKNQAGGLSGKPVKPFA 362 Query: 276 TEIIRRLSLELNG-RLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVT 334 + +R + L ++G GGI S A E AGA VQ+Y+ + ++GP LI I Sbjct: 363 LKALRTIHQYTKDTNLVLVGCGGISSGQDAIEFAKAGAHFVQLYTAYAYRGPGLIARIKD 422 Query: 335 HI 336 + Sbjct: 423 EV 424 >UniRef50_B9KHW9 Dihydroorotate dehydrogenase (PyrD) n=10 Tax=Rickettsiales RepID=B9KHW9_ANAMF Length = 389 Score = 310 bits (794), Expect = 5e-83, Method: Composition-based stats. Identities = 129/338 (38%), Positives = 197/338 (58%), Gaps = 11/338 (3%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPA-KPVNCMGLTFKNPLGL 60 ++ F F + PE AH L+ VR ++P + L F+ P+GL Sbjct: 39 FFRFSHSPRFWVPPEVAHGLVIFGLKHG----LFPEVRGQMPECLSIEVCHLRFRTPIGL 94 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAG DK+ E I L MGFG +E GTVT +PQ GN +PRLFR+VD + ++NR+GFNN G+ Sbjct: 95 AAGFDKNAEVIKPLIGMGFGFVEAGTVTKKPQSGNKRPRLFRIVDQKAVVNRLGFNNKGI 154 Query: 121 DNLVENV-KKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTP 179 ++ + +K + V G N+G NK +Y + +Y + YI IN+SSPNT Sbjct: 155 QRFIKKIDRKELNNLVFGANLGINKTCT--DPPAEYAEMVRSVYGLSSYITINVSSPNTA 212 Query: 180 GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNI 239 GLR LQ L ++L+++++ + + + VPI +KIAPD+S+E +A+ +V+H I Sbjct: 213 GLRDLQNRGPLSEILSSVRDARRSVDQA--ESVPIFLKIAPDISDELKQDIAEEIVKHKI 270 Query: 240 DGVIATNTTLDRSLVQGMKNCDQT-GGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGI 298 G+I +NTT D SL+ +N T GGLSGRPL ST ++ + L ++ +IG GG+ Sbjct: 271 SGLIVSNTTTDLSLLGKDRNKSITQGGLSGRPLFDLSTTVLSEMYSLLRDKVILIGCGGV 330 Query: 299 DSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 S A +KI AGASLVQ+Y+ +++G ++K+I + Sbjct: 331 SSGAQALQKIKAGASLVQLYTALVYEGFGVVKKINMEL 368 >UniRef50_C3XDT6 Dihydroorotate dehydrogenase n=4 Tax=Helicobacter RepID=C3XDT6_9HELI Length = 357 Score = 309 bits (792), Expect = 9e-83, Method: Composition-based stats. Identities = 124/343 (36%), Positives = 191/343 (55%), Gaps = 17/343 (4%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGTPF-----EALVRQKVPAKPVNCMGLTFKN 56 +Y +R L++ D E+ H F + ++ P + + GL F N Sbjct: 3 FYKKIRPYLYKCDAEKIHNFAIKVMKMPQKIPLFESMIAKCYCRIHENLAQDIHGLHFYN 62 Query: 57 PLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFN 116 P+GLA+G DK+ E + L ++GFG +E+G+VT PQ GN+KPR+FR V+ E L N MGFN Sbjct: 63 PIGLASGFDKNAEAVRPLASLGFGYLELGSVTQMPQDGNEKPRMFRHVEEESLQNAMGFN 122 Query: 117 NLGVDNLVENVKKAHY-DGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISS 175 N+G ++ ++K+ + LGINIGKNK+ +Y + ++ + Y Y N+SS Sbjct: 123 NIGARGMLAHLKEVYPFCIPLGINIGKNKNIAQGDSLKNYELSLDTLKDYGDYFTFNLSS 182 Query: 176 PNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLV 235 PNTPGLR LQ + +L+ K+ N PI +KI+PD+ E ++ V D+ + Sbjct: 183 PNTPGLRDLQNESFVKELMEMAKSTTN---------KPIFIKISPDMEIESMLAVCDAAI 233 Query: 236 RHNIDGVIATNTTLDRSLVQGMKNCDQ--TGGLSGRPLQLKSTEIIRRLSLELNGRLPII 293 ++ ++G+IATNT++D SLV + GGLSG+ + KS E++R L + + +I Sbjct: 234 QNGVNGIIATNTSIDYSLVSNPVKKNDVCFGGLSGKAISTKSKEVLRILGKNFHKKTTLI 293 Query: 294 GVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 VGGI E+I GASLVQI S I++GP LI + + Sbjct: 294 SVGGIGDSNEVYERIKLGASLVQILSSMIYEGPTLISRMNNEL 336 >UniRef50_B6KTR1 Dihydroorotate dehydrogenase n=4 Tax=Toxoplasma gondii RepID=B6KTR1_TOXGO Length = 592 Score = 309 bits (791), Expect = 1e-82, Method: Composition-based stats. Identities = 130/379 (34%), Positives = 193/379 (50%), Gaps = 49/379 (12%) Query: 2 YYPFVRKALFQ------LDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFK 55 +Y V LF+ LDPE AH +T + L + P + ++ A V+ GL F Sbjct: 185 FYEPVTSVLFRYFSSGPLDPETAHGYTME-LAKRGWLPVD--YDREESALNVDINGLKFL 241 Query: 56 NPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGF 115 +P+GLAAG DK E AL MGF +E+G++TP+PQPGN KPRLFRL + +INR GF Sbjct: 242 SPIGLAAGFDKHAEAPAALLRMGFSFLEVGSITPKPQPGNPKPRLFRLYEDRSVINRFGF 301 Query: 116 NNLGVDNLVENVKKAHYD---------GVLGINIGKNKDTPVEQGKDDYLICMEKIYAYA 166 N+ G D ++ GVLG+++GKNK + E D ++K+ +A Sbjct: 302 NSNGADYAQTQLEAFSEARLRDPFTAQGVLGVSLGKNKTS--EDAVADLREGVKKLGRFA 359 Query: 167 GYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQA-------------------- 206 ++ +N+SSPNTPGLR+LQ L ++ ++ + + L Sbjct: 360 DFLVVNLSSPNTPGLRSLQSASHLAAIIDGVQEELDALDRQAQAASQKQRNERRRHGGNP 419 Query: 207 ---------MHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGM 257 + VKIAPDLS EE +A + N+DG + +NTT+ R Sbjct: 420 EETKAFYANQTGRRPLFFVKIAPDLSMEEKESIAKVALEKNLDGFVVSNTTIQRPETLKS 479 Query: 258 KNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQI 317 +TGGLSGR L+ ST + + G+L II GG++S A +KI AGASLV++ Sbjct: 480 PAKSETGGLSGRALKHLSTACVSDMYKLTQGKLAIIATGGVESGRDALDKIEAGASLVEL 539 Query: 318 YSGFIFKGPPLIKEIVTHI 336 YS ++ GP + + + + Sbjct: 540 YSSMVYIGPQVARRVKNEL 558 >UniRef50_B4UG99 Dihydroorotate dehydrogenase n=23 Tax=Bacteria RepID=PYRD_ANASK Length = 364 Score = 309 bits (791), Expect = 1e-82, Method: Composition-based stats. Identities = 154/339 (45%), Positives = 201/339 (59%), Gaps = 7/339 (2%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 M +P +R LFQLDPER H L R+ A +PA V CMGL F P+GL Sbjct: 1 MLWPALRSVLFQLDPERVHHLAHWALHRVPLAVARARRPAPIPALAVRCMGLDFDGPVGL 60 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAG DK + L +GF +EIGT+TPRPQPGND+PRLFRL + L+NRMGFNN G+ Sbjct: 61 AAGFDKGDVALPGLFGLGFSHVEIGTITPRPQPGNDRPRLFRLPEHRALLNRMGFNNEGM 120 Query: 121 DNLVENVK---KAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPN 177 + + A G +GIN+GKNK TP E DYL C+E+++ YA Y+ +NISSPN Sbjct: 121 EACARRLAALPPAARLGPVGINVGKNKVTPNEDAAADYLACIERLHPYADYLVVNISSPN 180 Query: 178 TPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRH 237 TPGLR LQ +ALD LL A A P+ VK+APDLS E L + D + Sbjct: 181 TPGLRQLQERDALDRLLRACVRHL----AERAPGKPLLVKLAPDLSPEALDEAVDVAIAA 236 Query: 238 NIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGG 297 G++ATNTTL R+ V+ + GGLSG PL+ +T+++RR GR+PI+GVGG Sbjct: 237 GAAGIVATNTTLSRAGVERHPRAAEAGGLSGAPLERLATDVVRRCYARAAGRVPIVGVGG 296 Query: 298 IDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + A KI AGA+LVQ Y+G I+ GP + + + Sbjct: 297 VMDAEGAYAKIRAGATLVQAYTGLIYGGPGFVGRVNAGL 335 >UniRef50_A8Q682 Putative uncharacterized protein n=1 Tax=Malassezia globosa CBS 7966 RepID=A8Q682_MALGO Length = 665 Score = 308 bits (790), Expect = 1e-82, Method: Composition-based stats. Identities = 126/392 (32%), Positives = 186/392 (47%), Gaps = 61/392 (15%) Query: 2 YYPFVRKALFQL-DPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 + + L DPE + + + L + G T NP+GL Sbjct: 74 HRWLFPPMMELLTDPESGSKISIKLLEHGLAP---RDCGKDDEVLRTELFGKTLTNPIGL 130 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAG DK GE ID L +GFG +EIG++TP PQPGN PR+FRL +INRMGFN+ G Sbjct: 131 AAGFDKQGEAIDGLFDLGFGLVEIGSITPEPQPGNPTPRMFRLPLDAAVINRMGFNSEGH 190 Query: 121 DN-----------LVENV------------------------------------------ 127 + V+ V Sbjct: 191 EAVRERLHARLHKWVQRVLSAGEGLVSSVGAPAPEPTALAEAQVFANYPVINTSLLDDAH 250 Query: 128 --KKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQ 185 + D +L IN+GKNK + E DY+ ++ + AYA + IN+SSPNTPGLR LQ Sbjct: 251 VPRSLKQDRLLSINLGKNK-SSREDSVVDYVKGVQALGAYADMLVINVSSPNTPGLRRLQ 309 Query: 186 YGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIAT 245 L+ +L + ++D+ +P+ VK+APDLS+ EL VAD+ IDG+I + Sbjct: 310 RRSVLEGVLRDVVTARDDVAKQRIDSLPLVVKVAPDLSDAELEDVADAARASKIDGIIVS 369 Query: 246 NTTLDRS-LVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAA 304 NTT+ R + ++ + GGLSG P++ + ++ + G++P+IG GGI + A Sbjct: 370 NTTVSRPAGLLSTQHVHEAGGLSGPPVKPLALHALQVIYKRSEGKIPLIGCGGIMTAEDA 429 Query: 305 REKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 E AGAS VQ+Y+ ++GP L + I + Sbjct: 430 LEFARAGASAVQLYTALAYRGPGLPRRIKDDL 461 >UniRef50_A2VBP6 Dihydroorotate dehydrogenase, mitochondrial n=1 Tax=Dekkera bruxellensis RepID=A2VBP6_DEKBR Length = 442 Score = 308 bits (788), Expect = 2e-82, Method: Composition-based stats. Identities = 116/352 (32%), Positives = 177/352 (50%), Gaps = 30/352 (8%) Query: 10 LFQL--DPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKD 67 LF+ E+ H L+ A P V+ G T NP+G+AAG DK Sbjct: 74 LFRWCTTAEQGHHLGIALLKYG--IFPRAFGDHDDPILRVDLFGRTLANPIGMAAGFDKQ 131 Query: 68 GECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENV 127 E +DAL +GFG +E+GT+TP PQ GN +PR FRL E +INR G N+ G ++ + Sbjct: 132 AEAMDALYDLGFGIVEVGTITPEPQFGNPRPRFFRLNADETVINRYGLNSDGRLTILSRL 191 Query: 128 K-----------------KAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIA 170 + L +NIGKN++ DDYL+ ++ YA + Sbjct: 192 RVRLEKYLKKSNACKTNNSFREGKSLFVNIGKNRN---GDTIDDYLVGVDTFAPYADALV 248 Query: 171 INISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMH---HKYVPIAVKIAPDLSEEEL 227 +N+S P+ PG+R LQ + L +LLT ++ +++ + A + PI VK+APDLSE+E+ Sbjct: 249 LNVSCPSAPGVRDLQEKDVLLELLTKVREERDKVGANVIDPARKPPIIVKVAPDLSEKEI 308 Query: 228 IQVADSLVRHNIDGVIATNTTLDRSL--VQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLE 285 +AD + IDG++ +NTT R + + GGLSGR ++ S + R L Sbjct: 309 ADIADVAKKSKIDGILMSNTTTARPASLITKGPVVQEKGGLSGRAMRDISLKAFRTLRKY 368 Query: 286 LNGRLPI-IGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + IG GGI + A AGAS +++Y+ F ++GP + +I I Sbjct: 369 TKDSDLVLIGCGGIFTGKDAIAFAKAGASAIELYTSFAYRGPGIPDKIKDEI 420 >UniRef50_B3L830 Dihydroorotate dehydrogenase, putative n=1 Tax=Plasmodium knowlesi strain H RepID=B3L830_PLAKH Length = 556 Score = 308 bits (788), Expect = 3e-82, Method: Composition-based stats. Identities = 131/361 (36%), Positives = 195/361 (54%), Gaps = 32/361 (8%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 +Y F++ L +D E H+ F + + P++ GL F NP G+ Sbjct: 179 LYDIFLKFLLKYVDGEMCHDL-FLLMGKYNMLPYDTSKDSIYSC--TGIGGLNFINPFGV 235 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAG DK+G CID + +GF IE+GT+TP+PQ GNDKPR+FR V+ +IN GFNN+G Sbjct: 236 AAGFDKNGVCIDGILKLGFSFIEVGTITPKPQKGNDKPRIFRDVETRSIINCCGFNNIGC 295 Query: 121 DNLVENVKKAHYDG---------VLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAI 171 D + EN+K+ +G+++GKNKD+ +D C+ +I YA YIAI Sbjct: 296 DEVTENLKRFREKQKTDKLLHRHFVGVSLGKNKDS--ADILEDLSYCISRIGKYADYIAI 353 Query: 172 NISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAM---------------HHKYVP-IA 215 N+SSPNTPGLR Q E L ++ +K + + L+ K P + Sbjct: 354 NVSSPNTPGLRDNQQSERLQRIILRVKEEVDKLEESNVVGDDVVRGDTWVNTSKRKPLVF 413 Query: 216 VKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKS 275 VK+APDL E E ++AD L++ +DG+I NTT ++ ++ ++ GG+SG L+ S Sbjct: 414 VKLAPDLEEGEKKKIADVLLKTKVDGMIICNTTTEKFNIKNFQDKK--GGVSGEKLKDVS 471 Query: 276 TEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTH 335 T+ I ++ N ++PII GGI + A EKI AGAS+ Q+YS +F G I Sbjct: 472 TKFISQMYNYTNKKIPIIASGGIFTGKDALEKIEAGASVCQLYSCLVFNGMKAAVRIKRE 531 Query: 336 I 336 + Sbjct: 532 L 532 >UniRef50_P32747 Dihydroorotate dehydrogenase, mitochondrial n=2 Tax=Schizosaccharomyces RepID=PYRD_SCHPO Length = 443 Score = 307 bits (787), Expect = 3e-82, Method: Composition-based stats. Identities = 135/358 (37%), Positives = 188/358 (52%), Gaps = 45/358 (12%) Query: 15 PERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDGECIDAL 74 PE +H TP + + P+ V G F NP+GLAAG DK + I L Sbjct: 78 PEFSHRVAILAASW-GITPKDRV--ADDPSLAVEVWGKKFCNPIGLAAGFDKQADAISGL 134 Query: 75 GAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKKAHYDG 134 GF +EIG+VTP+PQPGN KPR FRL +INR GFN++G D ++ ++K Sbjct: 135 LNFGFSYLEIGSVTPKPQPGNPKPRYFRLKPDLSVINRYGFNSIGHDAILAKIQKRVRKY 194 Query: 135 V-----------------------------------LGINIGKNKDTPVEQGKDDYLICM 159 + LGIN+GKNK+ +DY+ + Sbjct: 195 IAKTSPQLLKQFDANPASCTDPAVLGVPRSLIPNKFLGINLGKNKN---GNEIEDYVEGV 251 Query: 160 EKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIA 219 +A + IN+SSPNTPGLR LQ AL LLTA+ +++N L + + P+ VKIA Sbjct: 252 RTFGNFADILVINVSSPNTPGLRNLQKKSALSTLLTAVVSERNKL---NSPHPPVLVKIA 308 Query: 220 PDLSEEELIQVADSLVRHNIDGVIATNTTLDRSL-VQGMKNCDQTGGLSGRPLQLKSTEI 278 PDL+EEEL +AD L + IDGVI NTT+ R ++ + ++TGGLSG PL+ + Sbjct: 309 PDLNEEELTDIADVLKKCKIDGVIVGNTTVQRPKTLKSTSHVEETGGLSGPPLKPIALNT 368 Query: 279 IRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 +R L L+ +PIIG GGI S A E AGA++VQ+Y+ + GP + +I I Sbjct: 369 LRTLRKHLSSDIPIIGCGGISSGKDAIEYARAGATMVQVYTALGYDGPVIAHKIKQEI 426 >UniRef50_C6XQ80 Dihydroorotate dehydrogenase n=1 Tax=Hirschia baltica ATCC 49814 RepID=C6XQ80_HIRBI Length = 362 Score = 306 bits (785), Expect = 6e-82, Method: Composition-based stats. Identities = 136/332 (40%), Positives = 197/332 (59%), Gaps = 4/332 (1%) Query: 9 ALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVN--CMGLTFKNPLGLAAGLDK 66 + QL PE AH T ++ + L +++ V+ GL NPLG+AAG DK Sbjct: 11 LIQQLPPETAHRATIAAMKFGLAGKAKPLSKKQSERLKVHLPISGLDLPNPLGIAAGFDK 70 Query: 67 DGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVEN 126 + + A+G G +E GTVTP+ Q GN KPRLFRL + G+INRMGFNN G+D+ V Sbjct: 71 NADAFVPSLALGCGFVECGTVTPQLQDGNPKPRLFRLKEDGGVINRMGFNNSGLDSFVHR 130 Query: 127 VKK-AHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQ 185 +K A GV+G N+G NK + E+ DY+ ++ ++ Y YI +NISSPNTPGLR LQ Sbjct: 131 LKNGAANQGVVGANVGANKTSEGEKRVGDYVDGIKAVWQYCAYITLNISSPNTPGLRGLQ 190 Query: 186 YGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVAD-SLVRHNIDGVIA 244 L LLTA +++ H P+ +KIAPD+ EE + + D L+ + G+I Sbjct: 191 NKSDLSALLTAASETILEMEDRHKTKRPVFLKIAPDIDEEAIRDIVDTVLLAKGMTGLIV 250 Query: 245 TNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAA 304 +NTT++R +N QTGGLSG+PL KST+++++++ +G+L IIG GGI +A Sbjct: 251 SNTTIERPSFLQSENAKQTGGLSGKPLFEKSTQVLKQVARIADGQLDIIGAGGIHDAKSA 310 Query: 305 REKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 KI AGA Q+YS +++G LI EI+ + Sbjct: 311 YLKIRAGAHCFQLYSALVYEGAALIPEILNGL 342 >UniRef50_C4QIG2 Dihydroorotate dehydrogenase n=3 Tax=Schistosoma RepID=C4QIG2_SCHMA Length = 379 Score = 304 bits (779), Expect = 3e-81, Method: Composition-based stats. Identities = 135/351 (38%), Positives = 190/351 (54%), Gaps = 25/351 (7%) Query: 2 YYPFVRKALFQL--DPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLG 59 Y + L D E AH + L P + R P GL F +P+G Sbjct: 31 YKDWFLPTARLLVRDGETAHNLSV-YLASYGFIPHKQ--RNSFPQLKCKVFGLEFDHPIG 87 Query: 60 LAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLG 119 LAAG DKDG+ L GF IE+GTVTP PQ GN +PR+FR + E ++NR GFN+ G Sbjct: 88 LAAGFDKDGKAFMGLLNAGFSHIEVGTVTPNPQLGNARPRIFRWTEKEAVVNRCGFNSDG 147 Query: 120 VDNLVENVKKAHYD--GVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPN 177 D + E +K ++ GV+G+N+G NK + DY+ + K A Y+ IN+SSPN Sbjct: 148 HDAVYERLKDRPWEGRGVIGVNLGCNKTS--ADPTADYVAGVRKFGEVADYLVINVSSPN 205 Query: 178 TPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRH 237 TPGLR+LQ E L DLL+ + +N L K PI +KI+PD +++ L + + + Sbjct: 206 TPGLRSLQTKEKLRDLLSKVLAARNQL----SKKTPILLKISPDENDQNLKDIVEVALDS 261 Query: 238 N--IDGVIATNTT----------LDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLE 285 IDG+I +NTT + K GGLSGRPL KST+ +R++S Sbjct: 262 KTRIDGMIISNTTLTTYEEAVACGAAPIPGNNKQNVVYGGLSGRPLFEKSTDCLRKVSAL 321 Query: 286 LNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 G +P+IGVGGI A K+ AGASLVQ+Y+ F+++GPP+ ++ I Sbjct: 322 TKGAIPLIGVGGISCGEDALSKLNAGASLVQLYTSFVYQGPPVAHKVAREI 372 >UniRef50_B5Z6I2 Dihydroorotate dehydrogenase n=28 Tax=Campylobacterales RepID=PYRD_HELPG Length = 351 Score = 304 bits (779), Expect = 3e-81, Method: Composition-based stats. Identities = 134/342 (39%), Positives = 188/342 (54%), Gaps = 18/342 (5%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPF-----EALVRQKVPAKPVNCMGLTFK 55 M YP V+K LF LD E AHE + LR ++ + F + K P +GL F Sbjct: 1 MLYPLVKKYLFSLDAEDAHEKVCKILRTLSKSSFLCSLIHSQWGYKNPKLENEILGLNFP 60 Query: 56 NPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGF 115 NPLGLAAG DK+ + AL A GFG +E GT+T Q GN++PRLFR ++ E L N MGF Sbjct: 61 NPLGLAAGFDKNASMLRALIAFGFGYLEAGTLTNEAQVGNERPRLFRHIEEESLQNAMGF 120 Query: 116 NNLGVDNLVENV-KKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINIS 174 NN G + + A Y +GIN+GKNK +DY + + Y N+S Sbjct: 121 NNYGAVLGARSFNRFAPYKTPIGINLGKNKHIEQAHALEDYKAVLNQCLNIGDYYTFNLS 180 Query: 175 SPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSL 234 SPNTP LR LQ +++L K + P+ +KIAPDL ++++++ +S Sbjct: 181 SPNTPNLRDLQNKAFVNELFCMAKEMT---------HKPLFLKIAPDLEIDDMLEIVNSA 231 Query: 235 VRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIG 294 + G+IATNTT+D+SLV K + GGLSG+ L KS E+ + L+ + ++ Sbjct: 232 IEAGAHGIIATNTTIDKSLVFAPK---EMGGLSGKCLTKKSREVFKELAKAFFNKSVLVS 288 Query: 295 VGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 VGGI A E+I GASL+QIYS FI+ GP L + I+ + Sbjct: 289 VGGISDAKEAYERIKMGASLLQIYSAFIYNGPNLCQNILKDL 330 >UniRef50_B7JXU8 Dihydroorotate dehydrogenase n=8 Tax=Cyanobacteria RepID=PYRD_CYAP8 Length = 377 Score = 303 bits (777), Expect = 4e-81, Method: Composition-based stats. Identities = 135/357 (37%), Positives = 198/357 (55%), Gaps = 30/357 (8%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGTP-----------FEALVRQKVPAKPVNCM 50 +YP V A +PE AH L + T + Sbjct: 8 FYPLVLTAAKS-NPEGAHLQLLNTLNTLERTHHTRGGNWLLSQLDQSFCVDDSRLKQTLW 66 Query: 51 GLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLI 110 GLTF NP+GLAAG DK+G +GFG E+G VT PQPGN +PRLFRL + ++ Sbjct: 67 GLTFNNPVGLAAGCDKEGIAAGIWSHLGFGFAELGAVTLHPQPGNPRPRLFRLPHDKAVL 126 Query: 111 NRMGFNNLGVDNLVENVK----KAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYA 166 NR+G NN G + + + + ++ + +GIN+ K+K TP+++ DY+ + A Sbjct: 127 NRLGANNQGAEIMAQTLAEIWQRSPRNIPIGINLCKSKITPLDEAAQDYVGSFSYLENQA 186 Query: 167 GYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEE 226 Y +N+SSPNTPGLR+LQ GE L+ +L A+ QA + P+ VKI+PDL EE Sbjct: 187 DYFVVNVSSPNTPGLRSLQEGEQLNSILQAL-------QAANQHQKPLFVKISPDLEEEA 239 Query: 227 LIQVADSLVRHNIDGVIATNTTLDRSL-------VQGMKNCDQTGGLSGRPLQLKSTEII 279 ++ + + H + G+IATNTT+ R G K ++ GG+SG P++ +STEII Sbjct: 240 ILTIIELAQTHCLAGIIATNTTIKRDRLTTQILPETGNKIQEEAGGISGLPIRDRSTEII 299 Query: 280 RRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + + G+LPIIGVGGI + A KI AGASL+Q+Y+G+I++GP +I +IV + Sbjct: 300 GFIYQKTQGKLPIIGVGGIFTPDDAWNKIIAGASLLQLYTGWIYQGPWIIPDIVRGL 356 >UniRef50_P74782 Dihydroorotate dehydrogenase n=24 Tax=Bacteria RepID=PYRD_SYNY3 Length = 381 Score = 303 bits (777), Expect = 4e-81, Method: Composition-based stats. Identities = 132/356 (37%), Positives = 197/356 (55%), Gaps = 29/356 (8%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGTP----------FEALVRQKVPAKPVNCMG 51 YP + + DPER H+ Q L+++ E P C G Sbjct: 8 LYPLILSV-TKSDPERGHQRLIQTLKKVDTMHRNGFAVAMEQLEQAFTHADPRLQQTCWG 66 Query: 52 LTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLIN 111 L F N LGL+AG DK+GE A+GFG E+G VT QPGND+PRLFRL + ++N Sbjct: 67 LNFPNVLGLSAGCDKEGEAAAVWPALGFGFAELGAVTKYAQPGNDRPRLFRLPQDQAVLN 126 Query: 112 RMGFNNLGVDNLVENVKKA----HYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAG 167 R+G NN G + +K +GIN+ K+K TP++Q +DY+ + + A Sbjct: 127 RLGANNEGAVAMAAKLKHTWDYYPRTIPIGINLCKSKITPLDQAVEDYVFSFQTLAPVAD 186 Query: 168 YIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEEL 227 Y +N+SSPNTPGLR+LQ + L + +++ +H P+ VKI+PDLS E + Sbjct: 187 YFVVNVSSPNTPGLRSLQESDELPRIFAGLQSA-------NHWQKPLLVKISPDLSWEAI 239 Query: 228 IQVADSLVRHNIDGVIATNTTLDRSLV-------QGMKNCDQTGGLSGRPLQLKSTEIIR 280 + D + HN+ G++ATNT+ RS + G + GGLSG+P++ ++TE+IR Sbjct: 240 AVIIDLVKEHNLSGIVATNTSTRRSGLKTKILPQTGQPIEQEAGGLSGQPIRDRATEVIR 299 Query: 281 RLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + + G +PIIGVGGI + A EKI AGAS +QIY+G+I+ GP ++ +I+ + Sbjct: 300 YIYQQTGGTIPIIGVGGIFTAEDAWEKIQAGASFLQIYTGWIYGGPWVVSDILQGL 355 >UniRef50_Q2GEM2 Dihydroorotate dehydrogenase n=2 Tax=Neorickettsia RepID=Q2GEM2_NEOSM Length = 348 Score = 303 bits (777), Expect = 4e-81, Method: Composition-based stats. Identities = 130/339 (38%), Positives = 185/339 (54%), Gaps = 14/339 (4%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 M+ + L +L+P AH+ T L+ G F + + P GL FKNP+G+ Sbjct: 1 MHEKLLVALLQRLNPSFAHDVTRVVLKHFPG--FVSQNSFEDPILESRVCGLHFKNPIGI 58 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAG DK+ EC+ AL +GFG IE+GTVT +PQ GN PRLFRL +INR+GFNN G+ Sbjct: 59 AAGFDKNAECVTALRRVGFGFIELGTVTLKPQKGNPSPRLFRLPQDGAIINRLGFNNKGI 118 Query: 121 DNLVENVKKAHYDG---VLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPN 177 ++++KKA LG+NIGKN + DY + + A YI +NISSPN Sbjct: 119 AYFLKSLKKAMTHMDLPPLGVNIGKNAVSS--NAVSDYARLAAYVSSVADYITLNISSPN 176 Query: 178 TPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRH 237 T LR +Q E L++LL A+K V I +K+APDL+E + + ++H Sbjct: 177 TVSLRDMQKVEILEELLIAVKAAV-------GSNVRIFIKVAPDLAEGAEVGIISLALKH 229 Query: 238 NIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGG 297 + G+I +NTT+ K+ + GGLSG PL ST ++R++ NG L IG GG Sbjct: 230 KVAGIIVSNTTIGCRESLHSKHKVEYGGLSGTPLFKLSTGLLRKMYRCTNGELVFIGCGG 289 Query: 298 IDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 I A KI GA+L+Q Y+ F + G L+ +I + Sbjct: 290 ISDAETAYAKIRNGAALIQAYTSFTYHGFGLLNQIKKDL 328 >UniRef50_D1SB76 Dihydroorotate dehydrogenase n=2 Tax=Micromonospora aurantiaca ATCC 27029 RepID=D1SB76_9ACTO Length = 377 Score = 303 bits (777), Expect = 5e-81, Method: Composition-based stats. Identities = 144/341 (42%), Positives = 200/341 (58%), Gaps = 20/341 (5%) Query: 1 MYYPFVRKALFQL---DPERAHEFTFQQLRRITGTP--FEALVRQKVPAKPVNCMGLTFK 55 ++ VR LF L D E AHE+T +L ++ P AL + P G+ F Sbjct: 44 IFEKVVRPRLFSLAGGDAEGAHEWTLARLAAVSRQPAVLAALRAAYFRSAPRTVFGVRFP 103 Query: 56 NPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGF 115 NP+GLAAG+DK+G + A A+GFG +E+GTVT QPGN +PRLFRL D+E +INRMGF Sbjct: 104 NPVGLAAGMDKNGLALPAWPALGFGFVEVGTVTAHAQPGNPRPRLFRLRDSEAVINRMGF 163 Query: 116 NNLGVDNLVENVK--KAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINI 173 NN G + L + + LGI++GK+K TP+++ +DYL + + Y A+N+ Sbjct: 164 NNAGAEALADRLAALPRPLGVPLGISLGKSKVTPLDEAVEDYLASYRALKDHGDYFAVNV 223 Query: 174 SSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADS 233 SSPNTPGLR+LQ LD LL A+ P+ VKIAPDL+E + ++ + Sbjct: 224 SSPNTPGLRSLQDRSHLDALLAALV-----------GEKPVLVKIAPDLTEPAVAELLEV 272 Query: 234 LVRHNIDGVIATNTTLDRSLVQG--MKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLP 291 + GVIATNTTL R + + + GGLSGRPL ++ E++ + E GRLP Sbjct: 273 CLDRGAAGVIATNTTLARDGLAPADRERAAEAGGLSGRPLTARAREMVAFVHRETGGRLP 332 Query: 292 IIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 +IGVGGI A AGASL+Q+Y+GFI++GP L + I Sbjct: 333 VIGVGGILHPDDATRMFDAGASLLQLYTGFIYRGPALTRAI 373 >UniRef50_C1EIH8 Dihydropryrimidine dehydrogenase n=1 Tax=Micromonas sp. RCC299 RepID=C1EIH8_9CHLO Length = 488 Score = 303 bits (775), Expect = 7e-81, Method: Composition-based stats. Identities = 139/375 (37%), Positives = 197/375 (52%), Gaps = 43/375 (11%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLA 61 + ++ A+ +DPE AH + L R P E R+ PA V+ GL F NP+GLA Sbjct: 92 LFEYLAPAMRLMDPETAHNVGIELLAR-GVAPVET--RRDPPALAVDAWGLRFANPIGLA 148 Query: 62 AGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVD 121 AG DKD + ALGAMGFG +EIG+VTP+PQPGN KPR+FRL + +INR GFN+ G + Sbjct: 149 AGFDKDAKAFPALGAMGFGFVEIGSVTPKPQPGNPKPRVFRLRELGAVINRYGFNSEGHE 208 Query: 122 NLVENVKKAHYDG-------------------------------VLGINIGKNKDTPVEQ 150 ++ D +G+N+GKNK TP Sbjct: 209 PARARLEAYRADTRATQSEFDATPVTPVTPEGAGVPRRLAERGAPVGVNLGKNKLTPEAA 268 Query: 151 GKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQ----- 205 DDY + + + A YI +NISSPNTPGLR LQ L LL + +++ Sbjct: 269 AADDYALGVRALGHTADYIVVNISSPNTPGLRALQGKAHLKGLLRKVLAARDESALKSRT 328 Query: 206 ---AMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLV-QGMKNCD 261 H P+ +KIAPDL++ ++ V + +DG+I +NTT+ R Sbjct: 329 GGGQTHAHKPPVLLKIAPDLTDGDIKDVVAAATSCAVDGIIVSNTTIARPEDVAAHARGG 388 Query: 262 QTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGF 321 + GGLSG+PL STE++ R+ G++P++G GG+ S A EKI AGASLVQ+Y+ F Sbjct: 389 EAGGLSGKPLMDPSTEVLFRVYQLTGGKIPLVGCGGVASGRDAYEKIRAGASLVQMYTAF 448 Query: 322 IFKGPPLIKEIVTHI 336 + GP L+ + + Sbjct: 449 AYAGPALVPAMKAEL 463 >UniRef50_Q5UF20 Predicted dihydroorotate dehydrogenase n=1 Tax=uncultured alpha proteobacterium EBAC2C11 RepID=Q5UF20_9PROT Length = 378 Score = 302 bits (774), Expect = 9e-81, Method: Composition-based stats. Identities = 133/344 (38%), Positives = 182/344 (52%), Gaps = 12/344 (3%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 M + + K L E AH+ L RQ V GL F NPLGL Sbjct: 1 MMWNLLAKLARHLPAEAAHQIAVAALH--YNVGPRPAQRQSKADLTVRIAGLEFANPLGL 58 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAG DK+ C + +GF +E+GT+TP+ QPGN KPR+FRL + +INR GFN+ G+ Sbjct: 59 AAGFDKNATCFNGAMGLGFAHVEVGTITPKRQPGNPKPRVFRLPEENAVINRYGFNSHGM 118 Query: 121 DNLVENVKKAHYD--GVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNT 178 D + +N+ G+LG+N+G NK + DDY + + YA YI +NISSPNT Sbjct: 119 DRVAKNLYATASKRVGILGVNVGANKTS--NDPIDDYRQAVAMLAPYADYITLNISSPNT 176 Query: 179 PGLRTLQYGEALDDLLTA----IKNK--QNDLQAMHHKYVPIAVKIAPDLSEEELIQVAD 232 PGLR LQ L DLL A + + ++ + PI +KIAPDL ++L + D Sbjct: 177 PGLRNLQTKRHLADLLMAGFAGCREAGFEPACRSTGLRQKPIFLKIAPDLRHDDLATIVD 236 Query: 233 SLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPI 292 S V G+IATNTT+ R + + GGLSG PL ST I+ ++ RL + Sbjct: 237 SCVETGASGIIATNTTIARPTGLSGVHAGEVGGLSGGPLFAASTGILAEVARLSQNRLAL 296 Query: 293 IGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 IGVGG+ S A KI GA +VQ+Y+G +GP L I+ + Sbjct: 297 IGVGGVSSGWQAYAKILVGADMVQLYTGLALEGPHLPNRILHEL 340 >UniRef50_D1B1W1 Dihydroorotate dehydrogenase n=2 Tax=Campylobacteraceae RepID=D1B1W1_SULD5 Length = 355 Score = 302 bits (774), Expect = 1e-80, Method: Composition-based stats. Identities = 128/341 (37%), Positives = 175/341 (51%), Gaps = 19/341 (5%) Query: 3 YPFVRKALFQLDPERAHEFTFQQLRRIT------GTPFEALVRQKVPAKPVNCMGLTFKN 56 Y ++K +F PE AH + P TF N Sbjct: 6 YGLMKKIMFNFSPETAHNIAEFFFKHGANYAPFILAPLAERFFIHDKRLEQTLFDRTFHN 65 Query: 57 PLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFN 116 P+GLAAG DK+ I L A+GFG IE GT+TP PQ GN KPR FR + E + N MGFN Sbjct: 66 PIGLAAGFDKNATMIKMLTALGFGHIEYGTMTPEPQSGNAKPRCFRFPEEESIQNAMGFN 125 Query: 117 NLGVDNLVENVKKAHY-DGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISS 175 N G+ + + ++ + L NIGKNK T E DY +++ + ++ +NISS Sbjct: 126 NEGMHKIAKRLESLYPFATPLAANIGKNKITSAENALKDYEKLIKRFKDVSDFLVVNISS 185 Query: 176 PNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLV 235 PNTPGLR LQ + +L K P+ +KIAPDL +E I++ + Sbjct: 186 PNTPGLRDLQNEAFIKELFMMAKELT---------CKPVLLKIAPDLEIKEAIELCSCAL 236 Query: 236 RHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGV 295 + G++ATNTT+D SL+ N GG+SG+ L KS + ++ E G+ +I V Sbjct: 237 ENGAKGIVATNTTIDYSLL---PNAKDFGGISGKVLCEKSFRMFEGIAKEFFGKTTLISV 293 Query: 296 GGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 GGIDS A ++ AGASL+QIYS FIFKGP L + I I Sbjct: 294 GGIDSAEEAYRRLKAGASLLQIYSAFIFKGPSLNRTINLGI 334 >UniRef50_D2PV93 Dihydroorotate dehydrogenase n=1 Tax=Kribbella flavida DSM 17836 RepID=D2PV93_9ACTO Length = 394 Score = 302 bits (773), Expect = 1e-80, Method: Composition-based stats. Identities = 147/371 (39%), Positives = 198/371 (53%), Gaps = 42/371 (11%) Query: 2 YYPFVRKALFQL---DPERAHEFTFQQLRRITGTP-----FEALVRQKVPAKPVNCMGLT 53 Y VR L++L D E AHE T LRR+T P G+ Sbjct: 5 YRTLVRPVLYRLGRGDAEVAHEQTLHGLRRLTRVPGAVSALSRSYGALPAGLARTVFGVR 64 Query: 54 FKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRM 113 F +P+GLAAG+DK+G + A A+GFG +E+GTVT PQPGN+KPRLFRLV++E +INRM Sbjct: 65 FPSPVGLAAGMDKNGIALPAWRALGFGFVEVGTVTAHPQPGNEKPRLFRLVESEAVINRM 124 Query: 114 GFNNLGVDNLVENVKKA-HYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAIN 172 GFNNLG L + + LGI+IGK+K TP+E +DY+ + ++Y + Y A+N Sbjct: 125 GFNNLGSAALADRLAAYGPLGYPLGISIGKSKVTPIEDAVEDYVTSLRRLYRFGDYFAVN 184 Query: 173 ISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKY--------------------- 211 +SSPNTPGLR+LQ L +LL A+ + L Sbjct: 185 VSSPNTPGLRSLQDAGHLRELLAALHTEAAALAGSGSGSGFGATSGSGAESRSGAESGSG 244 Query: 212 ----------VPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQG--MKN 259 PI VKIAPDL+E + ++ + G+IATNTT+ R + Sbjct: 245 AESGSGSGAVKPILVKIAPDLTEAAIDELLGVCTDAGVAGIIATNTTIGREALAPADQAL 304 Query: 260 CDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYS 319 + GGLSGRPL S + + + E G LPIIGVGGI A I AGASLVQ+Y+ Sbjct: 305 AAEAGGLSGRPLTEISAKTVAHIHAETGGALPIIGVGGILDPSDAARLIDAGASLVQLYT 364 Query: 320 GFIFKGPPLIK 330 G I++GP L++ Sbjct: 365 GLIYRGPGLVR 375 >UniRef50_A5U4G5 Dihydroorotate dehydrogenase n=31 Tax=Corynebacterineae RepID=PYRD_MYCTA Length = 357 Score = 301 bits (771), Expect = 3e-80, Method: Composition-based stats. Identities = 143/341 (41%), Positives = 194/341 (56%), Gaps = 15/341 (4%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGTPF-----EALVRQKVPAKPVNCMGLTFKN 56 YP VR+ LF + PE AH+ F LR + L+ P G+ F Sbjct: 1 MYPLVRRLLFLIPPEHAHKLVFAVLRGVAAVAPVRRLLRRLLGPTDPVLASTVFGVRFPA 60 Query: 57 PLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFN 116 PLGLAAG DKDG + + GAMGFG EIGTVT PQPGN PRLFRL D L+NRMGFN Sbjct: 61 PLGLAAGFDKDGTALSSWGAMGFGYAEIGTVTAHPQPGNPAPRLFRLADDRALLNRMGFN 120 Query: 117 NLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSP 176 N G L + + + +G+NIGK K TP +DY + A Y+ +N+SSP Sbjct: 121 NHGARALAIRLARHRPEIPIGVNIGKTKKTPAGDAVNDYRASARMVGPLASYLVVNVSSP 180 Query: 177 NTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVR 236 NTPGLR LQ E+L +L+A++ + + P+ VKIAPDLS+ +L +AD V Sbjct: 181 NTPGLRDLQAVESLRPILSAVRAETST---------PVLVKIAPDLSDSDLDDIADLAVE 231 Query: 237 HNIDGVIATNTTLDRSLVQGMKNCD-QTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGV 295 ++ G++ATNTT+ R + GG+SG PL ++ +++RRL + RL +I V Sbjct: 232 LDLAGIVATNTTVSRDGLTTPGVDRLGPGGISGPPLAQRAVQVLRRLYDRVGDRLALISV 291 Query: 296 GGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 GGI++ A E+I AGASL+Q Y+GFI+ G K+I I Sbjct: 292 GGIETADDAWERITAGASLLQGYTGFIYGGERWAKDIHEGI 332 >UniRef50_Q8D370 Dihydroorotate dehydrogenase n=46 Tax=Gammaproteobacteria RepID=PYRD_WIGBR Length = 337 Score = 299 bits (767), Expect = 7e-80, Method: Composition-based stats. Identities = 175/335 (52%), Positives = 235/335 (70%), Gaps = 1/335 (0%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 M Y + L + D E + + ++ TP L++ K P ++CMGL FKN LGL Sbjct: 1 MIYKIINFILSKKDHEEKKDLLLKIMKFFNKTPLNFLIKNKFPNNNISCMGLNFKNILGL 60 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAGLDK+G+ I +GFG IE+GTVT +PQ G KPRLF + G+INRMGFNN G+ Sbjct: 61 AAGLDKNGDYIKLFSDIGFGFIELGTVTLKPQHGEKKPRLFCFPNVYGIINRMGFNNNGI 120 Query: 121 DNLVENVKKAHY-DGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTP 179 +NL+EN+K +LGINIGKNKDT +E+ KDDYLIC+ K Y Y+ YI+INISSPNT Sbjct: 121 ENLIENIKNEKNVKSILGINIGKNKDTLIEKAKDDYLICINKAYYYSDYISINISSPNTK 180 Query: 180 GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNI 239 LR LQ+GE DLL +IK +QN L +++KYVPI +KI+PD++ E+IQ++D L+ +NI Sbjct: 181 DLRKLQFGELFSDLLKSIKEEQNKLNKIYNKYVPILIKISPDINNSEIIQISDCLLSYNI 240 Query: 240 DGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGID 299 DGVIATNTT+++ ++ N + GGLSG PL ST II++LS EL G++PIIG GGI Sbjct: 241 DGVIATNTTVNKDIIMRCCNNCEKGGLSGAPLNENSTRIIKKLSKELKGKIPIIGSGGII 300 Query: 300 SVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVT 334 SV +A+EKI AGASL+QIYSG +F G +IK+++ Sbjct: 301 SVKSAKEKIKAGASLIQIYSGLVFFGLKIIKKLIK 335 >UniRef50_A7AUQ8 Dihydroorotate dehydrogenase n=2 Tax=Piroplasmida RepID=A7AUQ8_BABBO Length = 415 Score = 299 bits (765), Expect = 1e-79, Method: Composition-based stats. Identities = 126/359 (35%), Positives = 188/359 (52%), Gaps = 30/359 (8%) Query: 2 YYPFVRKALF-QLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 Y + LDPE AH+ + L+ + P + V P + F NP+G+ Sbjct: 21 LYNVLMPLFRNYLDPEVAHKLSITALK-LGIAPVDYSV--DPPVIQSRLKDVVFFNPIGM 77 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAG DK E + MGFG +E+GTV P PQ GN KP +FRL D++ LIN GFN++G+ Sbjct: 78 AAGYDKQVEVPLQILRMGFGFVEVGTVLPLPQEGNPKPVMFRLHDSKALINCCGFNSVGL 137 Query: 121 DNLVENVKKAHYDGV---------LGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAI 171 + +K+ +G+++GKN+ D + ++ + YA YIAI Sbjct: 138 EVAKARLKRVRKKQASDPLTKDFMIGVSVGKNRT---GDILADTVNAVKGVAPYADYIAI 194 Query: 172 NISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAM----------HHKYVPIA-VKIAP 220 N+SSPNTP LR Q E L +++A ++ + K VP+ +KI+P Sbjct: 195 NVSSPNTPNLRDNQKREPLIAVISAARSALEIVNTEIKSKGAEFNNTTKKVPLLLIKISP 254 Query: 221 DLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGM---KNCDQTGGLSGRPLQLKSTE 277 D+S +EL +AD + H++DG+IATNTT+ R V + GGLSGRPL+ S + Sbjct: 255 DVSRQELEDIADISLTHHVDGIIATNTTITRDNVVPSDLKTAGNPKGGLSGRPLKTMSKK 314 Query: 278 IIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 I+ L G++PII GGI + A E I AGASL QIY+ +++GP + + + Sbjct: 315 IVYDLYELTEGKIPIIACGGISTAQDALEMIEAGASLCQIYTALVYEGPGIPSRMKNGL 373 >UniRef50_A9HBE5 Dihydroorotate oxidase n=10 Tax=Acetobacteraceae RepID=A9HBE5_GLUDA Length = 357 Score = 298 bits (764), Expect = 1e-79, Method: Composition-based stats. Identities = 123/345 (35%), Positives = 185/345 (53%), Gaps = 21/345 (6%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 + + + +LDPE AH + G + Q PA V +GL F NP+G+ Sbjct: 4 IMSNMLMPLVRRLDPEDAHRLGLNA--LLLGLGGGSGSGQDDPALAVRALGLRFPNPIGI 61 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAG DK+ + L +GFG +E GTVTPRPQPGN +PRLFRL + +INRMGFNN G+ Sbjct: 62 AAGFDKNALVVRPLARIGFGFVEAGTVTPRPQPGNPRPRLFRLDEDRAIINRMGFNNQGI 121 Query: 121 DNLVENVKKAHY----------DGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIA 170 D + + H +G N+G NK + DY + ++ YA Y+ Sbjct: 122 DRFAVRLARLHRVSPAGRHAGARVPVGANLGINKF--GADPERDYPRLVGRVKHYADYVV 179 Query: 171 INISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQV 230 +N+SSPNTPGLR LQ L LL AI H P+ VK++PDL+ +++ + Sbjct: 180 LNLSSPNTPGLRDLQEASRLGALLQAIGEA-------HPDRPPLLVKLSPDLARDDIGPI 232 Query: 231 ADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRL 290 ++ + G+I TNTT+ R + + GGLSGRPL+ + +I R ++ GRL Sbjct: 233 VEAAIAGGAQGLIVTNTTISRPAGLRSPHAGEAGGLSGRPLRPLAADIFRAVAQVAAGRL 292 Query: 291 PIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTH 335 ++ GGI++ +++ AGA LVQ+YS F ++GP +++ + Sbjct: 293 ALVACGGIETGADIVDRVRAGADLVQLYSAFAYEGPGIVRRLKRE 337 >UniRef50_D2UZD6 Predicted protein n=1 Tax=Naegleria gruberi RepID=D2UZD6_NAEGR Length = 369 Score = 298 bits (762), Expect = 3e-79, Method: Composition-based stats. Identities = 124/348 (35%), Positives = 200/348 (57%), Gaps = 30/348 (8%) Query: 13 LDPERAHEFTFQQLRRITGTPFEALVRQKVP-----AKPVNCMGLTFKNPLGLAAGLDKD 67 +DPE AH + ++ G + L + + NC+G F+NP+GLAAG DKD Sbjct: 1 MDPEDAHNLSKLAIKYGIGPKEKKLKANQYGLDPLISLHTNCLGYHFENPIGLAAGFDKD 60 Query: 68 GECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDA---------EGLINRMGFNNL 118 EC+ + +GFG +E+G++ P+PQPGN KPR+FRL + ++NR GFN+ Sbjct: 61 AECMKGIEKLGFGFMEVGSICPQPQPGNPKPRIFRLNSKVSDPDGTIFDTILNRCGFNSK 120 Query: 119 GVDNLVENVKKAHYD------GVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAIN 172 G++ EN+ +G+N+GKNK + E +DYLI + K+ +A ++ IN Sbjct: 121 GMEVSDENLTTYRNSYQSLNTFPIGVNLGKNKTSAPE-SIEDYLIGVRKLAKHADFLVIN 179 Query: 173 ISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVAD 232 +SSPNT LR+LQ +LD L+ + + HK +P+ +KIAPDL+ ++ +A Sbjct: 180 VSSPNTQHLRSLQEKSSLDTLIEEVSTELKK-----HKNIPLLIKIAPDLTLDQQRDIAS 234 Query: 233 SLVRHNIDGVIATNTTLDRSLVQGMK----NCDQTGGLSGRPLQLKSTEIIRRLSLELNG 288 ++H+I G+I +NTT++R V + GG+SGRPL +ST++++ + G Sbjct: 235 LALKHSIGGIIVSNTTIERPFVSSEQINAIPNGSAGGMSGRPLFNQSTKVLKNMYKLTEG 294 Query: 289 RLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 ++ +IGVGG+ A +KI AGASLVQ+Y+ F +GP ++ +I + Sbjct: 295 KVTLIGVGGVWDGYDALQKIQAGASLVQVYTAFTAQGPAVVGKIKREL 342 >UniRef50_Q827Q6 Dihydroorotate dehydrogenase n=12 Tax=Actinomycetales RepID=PYRD_STRAW Length = 368 Score = 296 bits (759), Expect = 6e-79, Method: Composition-based stats. Identities = 143/346 (41%), Positives = 203/346 (58%), Gaps = 12/346 (3%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPF-----EALVRQKVPAKPVNCMGLTFK 55 MY F R ++DPE+AH F+ +R P A + + GL Sbjct: 1 MYKLFFRLVFKRMDPEQAHYLAFRWIRLAARIPVLRTFVAAALAPRFKELRTEAFGLRMH 60 Query: 56 NPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGF 115 P GLAAG DK+ +D + +GF +EIGTVT PQPGN K RLFRLV LINRMGF Sbjct: 61 GPFGLAAGFDKNAVAVDGMSMLGFDHVEIGTVTGEPQPGNPKKRLFRLVPDRALINRMGF 120 Query: 116 NNLG--VDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINI 173 NN G ++A + V+G+NIGK K P E+ DDY+ E++ +A Y+ +N+ Sbjct: 121 NNEGSAAVAARLAAREAVFRTVVGVNIGKTKVVPEEEAADDYVKSTERLARHADYLVVNV 180 Query: 174 SSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADS 233 SSPNTPGLR LQ EAL LL+A++ + + + + VP+ VKIAPDL+++++ VAD Sbjct: 181 SSPNTPGLRNLQATEALRPLLSAVREAAD--RTVTERRVPLLVKIAPDLADDDIDAVADL 238 Query: 234 LVRHNIDGVIATNTTLDRSLV---QGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRL 290 V +DG+IATNTT+ R + +TGGLSG PL+ +S E++ RL + R+ Sbjct: 239 AVELGLDGIIATNTTIAREGLGLKSEPTLVKETGGLSGAPLKARSLEVLSRLYARVGDRI 298 Query: 291 PIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 ++GVGGI++ A ++I AGA+LVQ YS FI++GP + I + Sbjct: 299 TLVGVGGIENAEDAWQRILAGATLVQGYSAFIYEGPFWGRAIHKGL 344 >UniRef50_Q2S001 Dihydroorotate oxidase n=2 Tax=Rhodothermaceae RepID=Q2S001_SALRD Length = 366 Score = 294 bits (753), Expect = 3e-78, Method: Composition-based stats. Identities = 120/338 (35%), Positives = 179/338 (52%), Gaps = 19/338 (5%) Query: 14 DPERAHEFTFQQLRRITGTPF---EALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDGEC 70 +PE AH + R T + + + G TF NP+GLAAG DK+ Sbjct: 13 NPEWAHTASLWGARVAQRTVLPLVASRYQFEDERLKQRLWGDTFPNPVGLAAGADKNARA 72 Query: 71 IDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKKA 130 + A+GFG +E+G+V+ +P PGN PR FRL + LINR+G NN G + + + ++ + Sbjct: 73 VPFWEAVGFGFVEVGSVSAQPAPGNPTPRAFRLPKDQALINRLGLNNDGAEAVADRLEHS 132 Query: 131 HYD--GVLGINIGKN--KDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQY 186 D LGIN+ K D E +D+ ++ A Y+ +N+S PNTP T + Sbjct: 133 RSDRARPLGINLAKTHDPDIMGEAALEDFRTSFRQLVGQADYVTLNVSCPNTPDGGTFED 192 Query: 187 GEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLS-----EEELIQVADSLVRHNIDG 241 ALD LL AI +Q VP+ VK++P LS + L ++ H+IDG Sbjct: 193 PAALDALLGAITAEQK----APGLAVPVLVKLSPPLSDRVLFDTRLEEILAVAADHDIDG 248 Query: 242 VIATNTTLDRSLVQ---GMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGI 298 IATNT DR V+ + GGLSG PL+ ++T +++ L +G +PIIGVGG+ Sbjct: 249 FIATNTASDRKGVETSADRLDEIGAGGLSGPPLEARATRLVQYLYRATDGEIPIIGVGGV 308 Query: 299 DSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 +A KI AGASLVQ+Y+ +++GP L++ I + Sbjct: 309 HDAESAYTKIRAGASLVQLYTALVYEGPGLVRRIKEGL 346 >UniRef50_Q7RLG4 Dihydroorotate dehydrogenase, putative n=2 Tax=Plasmodium (Vinckeia) RepID=Q7RLG4_PLAYO Length = 512 Score = 294 bits (752), Expect = 3e-78, Method: Composition-based stats. Identities = 135/356 (37%), Positives = 196/356 (55%), Gaps = 27/356 (7%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 MY F+ L +D E H+ F L + P++ + L F NP G+ Sbjct: 136 MYDVFLDLCLKYVDSEVCHDL-FLLLGKYGLLPYDTSNDSVYA--TSDIKNLNFINPFGV 192 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAG DK+G CID++ +GF IEIGT+TP+PQ GNDKPR+FR V+ + +IN GFNN+G Sbjct: 193 AAGFDKNGICIDSILKLGFSFIEIGTITPKPQKGNDKPRIFRDVENKSIINACGFNNIGC 252 Query: 121 DNLVENV---------KKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAI 171 D + EN+ K ++G++IGKNK T E DD + KI YA YIAI Sbjct: 253 DKVTENLISFRKKQEEDKLLSKHIVGVSIGKNKYT--ENIVDDLKYSIYKIARYADYIAI 310 Query: 172 NISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHH----------KYVP-IAVKIAP 220 N+SSPNTPGLR Q L +++ +K + N ++ H K P + VK+AP Sbjct: 311 NVSSPNTPGLRDNQESNKLKNIILFVKQEINKIEESGHNGENFWMNTTKKKPLVFVKLAP 370 Query: 221 DLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIR 280 DL E ++A L+ IDG+I +NTT+++ ++ ++ GG+SG+ L+ ST +I Sbjct: 371 DLENSEKKKIAQVLLDTGIDGMIISNTTINKMDIKSFEDKK--GGVSGKKLKDLSTNLIS 428 Query: 281 RLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + + N ++PII GGI + A EKI AGAS+ Q+YS +F G +I Sbjct: 429 DMYIYTNKQIPIIASGGILTGADALEKIEAGASVCQLYSCLVFNGVKSAIQIKREF 484 >UniRef50_A5K1N1 Dihydroorotate dehydrogenase, mitochondrial, putative n=1 Tax=Plasmodium vivax RepID=A5K1N1_PLAVI Length = 572 Score = 293 bits (750), Expect = 6e-78, Method: Composition-based stats. Identities = 133/387 (34%), Positives = 195/387 (50%), Gaps = 58/387 (14%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 +Y F++ L +D E HE F + + P++ GL F NP G+ Sbjct: 169 LYDVFLKMLLKYVDGETCHEL-FLLMGKYKLLPYDTGKDNIYSC--SEIKGLNFINPFGV 225 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAG DK+G CID + +GF IEIGT+TP+ Q GN++PR+FR ++ +IN GFNN+G Sbjct: 226 AAGFDKNGVCIDGILKLGFSFIEIGTITPKAQKGNERPRIFRDLETRSIINSCGFNNMGC 285 Query: 121 DNLVENVKKAHYDG---------VLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAI 171 D + +N+K+ ++G+++GKNKD+P D C+ KI YA YIAI Sbjct: 286 DEVCKNLKRFRERQKTDKLLQRHLVGVSLGKNKDSP--DILQDLSYCIGKIGRYADYIAI 343 Query: 172 NISSPNTPGLRTLQYGEALDDLLTAIKNKQNDL-----------------------QAMH 208 N+SSPNTPGLR Q GE L ++ +K + L +A+ Sbjct: 344 NVSSPNTPGLRDHQKGERLHGIIQRVKEEVAKLDGGGAPLGGATTGGAAMGGATTGEAVV 403 Query: 209 HKYVP-------------------IAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTL 249 K P I VK+APDL E E +A+ L+ +DG+I NTT Sbjct: 404 GKAPPDEAATGGEPWANTTKRRPLIFVKLAPDLEEGERKSIANVLLNAEVDGMIICNTTT 463 Query: 250 DRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIA 309 + ++ ++ GG+SG L+ ST +I ++ NG++PII GGI + A EKI Sbjct: 464 QKFNIKSFEDKK--GGVSGEKLKGVSTHMISQMYNYTNGKIPIIASGGIFTGEDALEKIE 521 Query: 310 AGASLVQIYSGFIFKGPPLIKEIVTHI 336 AGAS+ Q+YS +F G I + Sbjct: 522 AGASVCQLYSCLVFNGMKAAVRIKREL 548 >UniRef50_B9L9P6 Dihydroorotate dehydrogenase n=7 Tax=Epsilonproteobacteria RepID=PYRD_NAUPA Length = 359 Score = 293 bits (749), Expect = 8e-78, Method: Composition-based stats. Identities = 129/341 (37%), Positives = 193/341 (56%), Gaps = 18/341 (5%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGTPFE-----ALVRQKVPAKPVNCMGLTFKN 56 ++ V+ +++ DPE AH+ +R P L FKN Sbjct: 3 FFNMVKPLIYKTDPELAHDLVDLAMRTARRCPLFFNPLVKANFVDDVMLHQKIWDLEFKN 62 Query: 57 PLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFN 116 P+G+AAG DK + A+GFG EIG VTP+PQPGN+KPR +R ++ E + N GFN Sbjct: 63 PVGVAAGFDKHATMVYGWPALGFGWGEIGAVTPKPQPGNEKPRAWRHIEYEAVQNAYGFN 122 Query: 117 NLGVDNLVENVKKAHYDG-VLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISS 175 N GV+ + + +KK + +G NIGKNK TP E+ +DY I + ++ + +N+SS Sbjct: 123 NEGVEVIKKRLKKIYPFILPIGANIGKNKTTPEERAVEDYKILVNELKDVVDFFVVNVSS 182 Query: 176 PNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLV 235 PNTPGLR L E + L +KN + PI +K +PD+ +E +I +A+ V Sbjct: 183 PNTPGLRDLLNAEFISSLFGELKNLTD---------KPILIKFSPDMEDELIINLANYSV 233 Query: 236 RHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGV 295 DG+I TNTT++ LV GG+SG+PL +S E++R ++ E+ G++PII V Sbjct: 234 LAGADGIIVTNTTVNYDLVNSEIK---RGGISGKPLAQRSYEVLRIVAGEVFGKVPIISV 290 Query: 296 GGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 GGIDS A ++I AGASL+Q+Y+ I+KGP ++ EI + Sbjct: 291 GGIDSAEEAYKRIKAGASLLQVYTAIIYKGPGIVGEINRGL 331 >UniRef50_Q5KK62 Dihydroorotate dehydrogenase, mitochondrial, putative n=3 Tax=Agaricomycotina RepID=Q5KK62_CRYNE Length = 591 Score = 291 bits (744), Expect = 3e-77, Method: Composition-based stats. Identities = 128/368 (34%), Positives = 183/368 (49%), Gaps = 35/368 (9%) Query: 1 MYYPFVRKALFQL-DPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLG 59 ++ + + DPE+ H+ + L + G+ KNP+G Sbjct: 60 LHEHVAMPLMRLVADPEQGHKLAVRVLAWDKWARP-RDMGVDGAELQAELFGMHLKNPVG 118 Query: 60 LAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLG 119 +AAG DKD E ID L +GFG +E+G+VTP PQPGN KPR FRL + + INR GFN+LG Sbjct: 119 IAAGFDKDAEAIDGLFDLGFGYVEVGSVTPEPQPGNPKPRFFRLEEDDACINRYGFNSLG 178 Query: 120 V-----------DNLVEN-------------------VKKAHYDGVLGINIGKNKDTPVE 149 ++ + +L +N+GKNK + Sbjct: 179 HGHALARLRLRLAKFAQDHPSLFPSPLPANLVPPAGLPRSLRAGQLLAVNLGKNKASDP- 237 Query: 150 QGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHH 209 DDY+ + + +A + IN+SSPNTPGLR LQ + L+ LL + ++N + Sbjct: 238 DSNDDYVRGVRTLGPFADVVVINVSSPNTPGLRALQGKQQLERLLNDVVEERNKIAQGTG 297 Query: 210 KYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDR-SLVQGMKNCDQTGGLSG 268 IAVK+A DLSE+EL VA ++ ++GVI +NTT+ R L N DQ GGLSG Sbjct: 298 LPK-IAVKVASDLSEDELADVASAVRSSGVEGVIVSNTTIRRKELNLVSGNQDQIGGLSG 356 Query: 269 RPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPL 328 +PL + ++ L L +PIIG GGI S A AGAS+VQ+Y+ F F+G Sbjct: 357 KPLFPYALNALKTLRPLLPPSIPIIGCGGISSGSDALTMANAGASIVQVYTSFGFRGVGT 416 Query: 329 IKEIVTHI 336 + I I Sbjct: 417 PRLIKDEI 424 >UniRef50_Q08210 Dihydroorotate dehydrogenase homolog, mitochondrial n=4 Tax=Plasmodium RepID=PYRD_PLAF7 Length = 569 Score = 289 bits (740), Expect = 8e-77, Method: Composition-based stats. Identities = 137/387 (35%), Positives = 199/387 (51%), Gaps = 58/387 (14%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 +Y F++ L +D E H+ F L + P++ N L F NP G+ Sbjct: 167 LYDIFLKFCLKYIDGEICHDL-FLLLGKYNILPYDTSNDSIYAC--TNIKHLDFINPFGV 223 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAG DK+G CID++ +GF IEIGT+TPR Q GN KPR+FR V++ +IN GFNN+G Sbjct: 224 AAGFDKNGVCIDSILKLGFSFIEIGTITPRGQTGNAKPRIFRDVESRSIINSCGFNNMGC 283 Query: 121 DNLVENV---------KKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAI 171 D + EN+ K ++G++IGKNKDT DD C+ KI YA YIAI Sbjct: 284 DKVTENLILFRKRQEEDKLLSKHIVGVSIGKNKDTV--NIVDDLKYCINKIGRYADYIAI 341 Query: 172 NISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQA------------------------- 206 N+SSPNTPGLR Q L +++ ++K + ++L+ Sbjct: 342 NVSSPNTPGLRDNQEAGKLKNIILSVKEEIDNLEKNNIMNDESTYNEDNKIVEKKNNFNK 401 Query: 207 -----------------MHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTL 249 K + VK+APDL++E+ ++AD L+ NIDG+I +NTT Sbjct: 402 NNSHMMKDAKDNFLWFNTTKKKPLVFVKLAPDLNQEQKKEIADVLLETNIDGMIISNTTT 461 Query: 250 DRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIA 309 + ++ +N GG+SG L+ ST+ I + N ++PII GGI S + A EKI Sbjct: 462 QINDIKSFENKK--GGVSGAKLKDISTKFICEMYNYTNKQIPIIASGGIFSGLDALEKIE 519 Query: 310 AGASLVQIYSGFIFKGPPLIKEIVTHI 336 AGAS+ Q+YS +F G +I + Sbjct: 520 AGASVCQLYSCLVFNGMKSAVQIKREL 546 >UniRef50_Q6SZS6 Dihydroorotate dehydrogenase, mitochondrial n=10 Tax=Saccharomycetales RepID=PYRD2_KLUMA Length = 446 Score = 289 bits (740), Expect = 9e-77, Method: Composition-based stats. Identities = 133/358 (37%), Positives = 194/358 (54%), Gaps = 36/358 (10%) Query: 10 LFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDGE 69 L D E H+ L+ + VN G T NP+G AAGLDKDGE Sbjct: 74 LLTPDAEAGHKLGIWLLKYGLAPRLW--FDKDEELLHVNVFGKTLTNPVGCAAGLDKDGE 131 Query: 70 CIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKK 129 ID + A GFG +EIG+VTP PQPGN KPR FRL E +INR GFN+ G D++V+N++ Sbjct: 132 AIDGIFAGGFGYVEIGSVTPLPQPGNPKPRFFRLPMDEAVINRYGFNSSGHDSVVKNLQN 191 Query: 130 A---------------------HYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGY 168 + + +LGIN+GKNK+ DYL +EK YA Sbjct: 192 RVSRFINSYFCNDINAVDNLSLYQNKLLGINLGKNKN---GDEVQDYLKGVEKFQKYADV 248 Query: 169 IAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHH------KYVPIAVKIAPDL 222 + IN+SSPNTPGLR LQ L +LL+ + K++ L + + P+ VK+APDL Sbjct: 249 LVINVSSPNTPGLRGLQKESILTNLLSQVVAKRDSLVSSGNVLGAKTHRPPVLVKVAPDL 308 Query: 223 SEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCD---QTGGLSGRPLQLKSTEII 279 EEE+ +A++ + +DG+I +NTT+ R ++ + Q GGLSG+PL+ S + + Sbjct: 309 EEEEIKAIAEAAKKSKVDGIIVSNTTIQRPASLITEDKNLVAQAGGLSGKPLKPLSLKAL 368 Query: 280 RRLSLELNGRLPI-IGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + ++ G + +G GGI S A E AGA++V++Y+ + ++GP LI + I Sbjct: 369 KTMAHYTKGSGLVLVGCGGISSGADAIEFAKAGATMVELYTCYAYRGPGLIARVKDEI 426 >UniRef50_C0W1V7 Possible dihydroorotate oxidase n=1 Tax=Actinomyces coleocanis DSM 15436 RepID=C0W1V7_9ACTO Length = 341 Score = 285 bits (729), Expect = 2e-75, Method: Composition-based stats. Identities = 125/353 (35%), Positives = 181/353 (51%), Gaps = 33/353 (9%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPF------------EALVRQKVPAKPVN 48 MY + DPE AH L P + + P Sbjct: 1 MYRWLFDNLITHSDPETAHNLVMNALTVAGSNPVSRAAIRATFNPTDTSLEPNASFLPKR 60 Query: 49 CMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEG 108 G LGLAAG+DK+ E I A A+GFG IEIGT+TP+ QPGN +PRL+RL + Sbjct: 61 VQGR-----LGLAAGMDKNAEAIHAFSALGFGFIEIGTITPKGQPGNPQPRLWRLPETRE 115 Query: 109 LINRMGFNNLGVDNLVENVKKAH-----YDGVLGINIGKNKDTPVEQGKDDYLICMEKIY 163 + N+MGFNN GVD + + K V+G NIGKNK T ++ +DY IC + Sbjct: 116 IRNQMGFNNHGVDAALLKLTKLRSTEAGRKIVVGSNIGKNKITSNDEALNDYEICASTLA 175 Query: 164 AYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLS 223 + ++ IN+SSPNTPGLR LQ E+L + ++ Q + V + +KIAPDL+ Sbjct: 176 PLSDFLVINVSSPNTPGLRDLQTVESLRPI---VETTQESANNAAQRDVSVFIKIAPDLA 232 Query: 224 EEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLS 283 +E+++ VAD + + GV+A NTT+ K+ ++GG+SG L + +I+ L Sbjct: 233 DEDILAVADLVNETGLTGVVAANTTI--------KHSYESGGISGPRLLNRGLDIVANLR 284 Query: 284 LELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 EL+ IIGVGGI + A + AGA L++ + FI++GP I + Sbjct: 285 KELDYDKTIIGVGGISTPDDAISYLDAGADLLEALTAFIYEGPAFPGRINRAV 337 >UniRef50_A9F3A8 PyrD protein n=1 Tax=Sorangium cellulosum 'So ce 56' RepID=A9F3A8_SORC5 Length = 407 Score = 284 bits (726), Expect = 4e-75, Method: Composition-based stats. Identities = 136/350 (38%), Positives = 182/350 (52%), Gaps = 19/350 (5%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRIT-GTPFEALVR----QKVPAKPVNCMGLTFKN 56 Y VR LF L P AHE L I P ALV + V MGL F + Sbjct: 30 MYRLVRPLLFALPPSLAHELGMLALAPIEHAAPLRALVHARLAPRDGRIAVRTMGLDFPS 89 Query: 57 PLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFN 116 PLG+A G DKD AL A+GFG +E+GTVT +PQ N P LFRL LINR+GF Sbjct: 90 PLGVAGGFDKDARRARALAALGFGFVELGTVTAQPQAANPPPNLFRLPADRALINRLGFP 149 Query: 117 NLGVDNLVENVK----KAHYDGVLGINIGKNKD---TPVEQGKDDYLICMEKIYAYAGYI 169 N G + E + A +GI+IGK++ P+E DDYL + A ++ Sbjct: 150 NQGAARVTERLLGRGGTAAVGVPVGISIGKSRVAPLDPIEPAIDDYLASFREARRAADFV 209 Query: 170 AINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQ 229 IN+SSPNT LR +Q LL+AI + +P+ +K+APDL +EEL Sbjct: 210 VINVSSPNTKDLRAMQGPAIARALLSAIARE----NRAAGAPLPLLIKVAPDLGDEELEA 265 Query: 230 VADSLVRHNIDGVIATNTTLDRSLVQGMK---NCDQTGGLSGRPLQLKSTEIIRRLSLEL 286 + + + GVIATNTT+ R + GGLSG PL+ +S ++RR+ L Sbjct: 266 LLAVVEEVGLAGVIATNTTVRRDGLATSPADVEAMGAGGLSGPPLRQRSLAMVRRIRARL 325 Query: 287 NGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + +IG GGI+S A +++ AGA LVQIY+GFI+ GP L EI + Sbjct: 326 GSNVTVIGAGGIESAEHAMDQLQAGADLVQIYTGFIYGGPLLPAEIARGL 375 >UniRef50_C6IFT5 Dihydroorotate dehydrogenase 2 n=7 Tax=Bacteroides RepID=C6IFT5_9BACE Length = 332 Score = 283 bits (723), Expect = 8e-75, Method: Composition-based stats. Identities = 122/343 (35%), Positives = 179/343 (52%), Gaps = 20/343 (5%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRIT-GTPFEALVRQKVP-AKPVNCMGLTFKNPL 58 MY VR LF +DPE+ H L+ P A VR +P + L FKN + Sbjct: 1 MYNLIVRPLLFLIDPEKVHRMLLNWLKIYRYLLPVRACVRGHYQVDEPFSYGSLRFKNRI 60 Query: 59 GLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNL 118 GL+AG DK+ E D L GFG +E+GTVTP QPGN PR+FRLV+ E LI+R GFNN Sbjct: 61 GLSAGFDKNAETFDELADFGFGFLEVGTVTPDYQPGNPSPRIFRLVEDESLISRTGFNNC 120 Query: 119 GVDNLVENVKK-AHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPN 177 GVD +E+++K + LG+NI KN + EQ D+ + ++Y Y +N S Sbjct: 121 GVDVALEHIRKYRKHSYRLGVNINKNPLSAGEQIIKDFELVFTRLYESVDYFTLNWGSI- 179 Query: 178 TPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRH 237 E+ +L + + + +K I +K+ D+ E+ L V ++ Sbjct: 180 --------DKESFAKVLENLTTFRQAV----NKRCSIFIKLPADIDEKALDLVISLAYKY 227 Query: 238 NIDGVIATNTTLDRSLVQGMKNCD----QTGGLSGRPLQLKSTEIIRRLSLELNGRLPII 293 +I+G IAT T+DRS + K GG+SGR + KS +++R LS + II Sbjct: 228 SIEGFIATGPTMDRSELHHTKTKQLEKIGNGGVSGRGIGKKSQKVVRYLSGHTDHHFLII 287 Query: 294 GVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 G GGI + A + I+ GA ++QIYS FI+ GP ++ +I + Sbjct: 288 GAGGIMTAEDAADMISQGADMIQIYSAFIYSGPSVVHKIGKKL 330 >UniRef50_Q7U3U2 Dihydroorotate dehydrogenase n=30 Tax=cellular organisms RepID=PYRD_SYNPX Length = 396 Score = 280 bits (717), Expect = 4e-74, Method: Composition-based stats. Identities = 129/351 (36%), Positives = 177/351 (50%), Gaps = 38/351 (10%) Query: 13 LDPERAHEFTFQQLRRITGTPFEALVR--------------QKVPAKPVNCMGLTFKNPL 58 LD E + + L + ++ G F NP+ Sbjct: 26 LDAE---QLSCTALTALGQASLRRQWPLVSTVLEGLAGDLQRRDLRLEQVLFGCRFPNPV 82 Query: 59 GLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNL 118 GLAAG DK+G GFG E+GTVT QPGN +PRLFRL + +NRMGFNN Sbjct: 83 GLAAGFDKNGVAAGLWDRFGFGFAEVGTVTWHGQPGNPRPRLFRLAQEQAALNRMGFNND 142 Query: 119 GVDNLVENVKKA------HYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAIN 172 G L +++ VLGIN+GK+K T +EQ +DY +E + A Y IN Sbjct: 143 GAQALRRTLERQRLAPPGRRPAVLGINVGKSKVTALEQAPEDYASSLELLAPLADYAVIN 202 Query: 173 ISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVAD 232 +SSPNTPGLR LQ + + P+ VKIAPDL +E + +A Sbjct: 203 VSSPNTPGLRDLQDSSQ--------LRRLVERLRRLPACPPLLVKIAPDLEDEAIDGIAR 254 Query: 233 SLVRHNIDGVIATNTTLDRSLVQGMK-------NCDQTGGLSGRPLQLKSTEIIRRLSLE 285 + GVIA NT+LDR ++ + ++ GGLSG PL+ ++ E+IRRL Sbjct: 255 LAFEEGLAGVIAVNTSLDRLGLEQRRLLQTGRTLAEEAGGLSGAPLRQRALEVIRRLRAS 314 Query: 286 LNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 L +IGVGGIDS A E+I AGASL+Q+Y+G+IF+GP L+ I+ + Sbjct: 315 AGPALTLIGVGGIDSAEIAWERITAGASLIQLYTGWIFQGPELVPRILEGL 365 >UniRef50_C2BWU0 Possible dihydroorotate oxidase n=3 Tax=Mobiluncus RepID=C2BWU0_9ACTO Length = 348 Score = 280 bits (717), Expect = 4e-74, Method: Composition-based stats. Identities = 129/356 (36%), Positives = 184/356 (51%), Gaps = 31/356 (8%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPF------------EALVRQKVPAKPVN 48 MY R +LD E H L E +P + Sbjct: 1 MYKFVFRHLFVKLDAEWVHRRAIDWLEFWGRFGLTRQVAARIVHRGEPTFTWPLPRPNFD 60 Query: 49 --CMGLTFKN--PLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLV 104 G F+ PLGLAAG+DK+ I A+GFG +EIGT+TP PQPGND+PRL+R+ Sbjct: 61 SAPAGTKFRTYGPLGLAAGMDKEARAIAMWDALGFGFMEIGTITPLPQPGNDRPRLWRIP 120 Query: 105 DAEGLINRMGFNNLGVDNLVENVKKAHYD----GVLGINIGKNKDTPVEQGKDDYLICME 160 L N MGFNN G +++ + ++G NIGKNK TP E+ DY Sbjct: 121 QQRALRNAMGFNNEGARAAARRLRRWRAEYGERIIIGANIGKNKVTPPEKAPADYRKVTR 180 Query: 161 KIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAP 220 + A ++ IN+SSPNTPGLR LQ A+ LL +K Q +L++ +P+ VKIAP Sbjct: 181 VLAALVDFLVINVSSPNTPGLRDLQ---AVSSLLPIVKAVQRELESQGLSELPVFVKIAP 237 Query: 221 DLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIR 280 DL +E++ VA + + GV+ATNTT+ L GG+SG PL+ ++ E+++ Sbjct: 238 DLVDEDIAAVAQLTMDEGLTGVVATNTTIKHDL--------GAGGMSGEPLRNRALEVVK 289 Query: 281 RLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 L L+ IIGVGGI + AR +AAGA+L++ +S FI++GP + + Sbjct: 290 LLREHLSPEKTIIGVGGITTPEDARAMLAAGANLIEGFSAFIYEGPAWPAHLNREL 345 >UniRef50_D1CE91 Dihydroorotate dehydrogenase n=1 Tax=Thermobaculum terrenum ATCC BAA-798 RepID=D1CE91_THET1 Length = 376 Score = 276 bits (707), Expect = 6e-73, Method: Composition-based stats. Identities = 125/350 (35%), Positives = 182/350 (52%), Gaps = 19/350 (5%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALV---------RQKVPAKPVNCMG 51 +Y V L +LD E HE L + P R P V+ G Sbjct: 5 IYKHLVLPLLDRLDSETWHERVRHGLHTVEQVPLGPEFLEILAWKGRRVVDPRLKVSLAG 64 Query: 52 LTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLIN 111 + +NPL + AG DK G I AL A+GF S+E+GTVTPRPQPGN +PR F ++ + +IN Sbjct: 65 VQLENPLIVGAGWDKSGISIRALYALGFASVEVGTVTPRPQPGNPRPRQF-VLSSGVVIN 123 Query: 112 RMGFNNLGVDNLVENVKKAHYD-GVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIA 170 R+GFNN G D + N++ D +GI+IGKNKD P ++ Y K+Y Y Y Sbjct: 124 RLGFNNPGADAVAANLESYKSDNIPVGISIGKNKDDPEDRAPLAYAEVARKLYPYGSYFV 183 Query: 171 INISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQV 230 IN+SSPNTPGLR+LQ EAL + ++ + + + P+ +KIAP+LS +E+ ++ Sbjct: 184 INVSSPNTPGLRSLQRKEALLSIAQSVLDVMDS----YGARKPLFIKIAPELSYQEVDEI 239 Query: 231 ADSLVRHNIDGVIATNTTLDRSLVQGMKNC--DQTGGLSG--RPLQLKSTEIIRRLSLEL 286 D +++ + GV+ATNT + Q GGLSG + ST + + + Sbjct: 240 LDVVLQLGLAGVVATNTVALGDVKARYGEGWRLQPGGLSGDDEVFRHMSTSKVAYIYSQT 299 Query: 287 NGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 G + IIGVGG+ A EKI AGA+ VQ+ + +G + + Sbjct: 300 KGSIDIIGVGGVKDAHTALEKILAGATAVQVVTAIRSEGLAVAARTNLGL 349 >UniRef50_Q6MPX3 PyrD protein n=1 Tax=Bdellovibrio bacteriovorus RepID=Q6MPX3_BDEBA Length = 327 Score = 275 bits (703), Expect = 2e-72, Method: Composition-based stats. Identities = 109/334 (32%), Positives = 164/334 (49%), Gaps = 18/334 (5%) Query: 6 VRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAAGLD 65 +R L L P+ AH+ + L + K GL F NP+G+A G+D Sbjct: 1 MRPWL-LLPPQWAHDLSSLGLPLYSLIHGRKTPHWK----SFTWRGLEFANPMGIAGGVD 55 Query: 66 KDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVE 125 K+ E + A+G G +E+GT+TPR Q N + R ++ + + N+MGF + G D + Sbjct: 56 KNAEHLKEWWALGCGFVEVGTITPRAQTPNPGKIMDRDLELQAMWNKMGFPSDGGDEVFH 115 Query: 126 NVKKA--HYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRT 183 N+ +Y + +NIGKN+ TP DYL +++ +A +NISSPNT GLR Sbjct: 116 NLASYAPNYRTPIFVNIGKNRHTPNNDAVADYLTLVDQFRPFADAFVVNISSPNTAGLRD 175 Query: 184 LQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVI 243 LQ E L L+ I + + H + P+ VK++PD+ EE L + + +DG + Sbjct: 176 LQKKENLRALIGPIVD-----RVSHFEPTPVLVKLSPDMGEEGLAEAVSNCQELGVDGFV 230 Query: 244 ATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRL---PIIGVGGIDS 300 TNTTL R GGLSG PL+ S ++ L + ++ VGGI S Sbjct: 231 LTNTTLSRPAGCHFPA---EGGLSGAPLKQLSQRALQIAVQTLGKKREGLLLVSVGGIMS 287 Query: 301 VIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVT 334 E++ GA LVQIYS +F GP ++ Sbjct: 288 PEDVFERLQMGADLVQIYSALVFHGPGFFHDVAR 321 >UniRef50_B5CXJ8 Putative uncharacterized protein n=3 Tax=Bacteroides RepID=B5CXJ8_9BACE Length = 349 Score = 274 bits (701), Expect = 3e-72, Method: Composition-based stats. Identities = 119/344 (34%), Positives = 175/344 (50%), Gaps = 23/344 (6%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQ---KVPAKPVNCMGLTFKNP 57 MY +R LF++D E+ H L P + + + A P LTF N Sbjct: 21 MYKSILRPWLFRMDAEKIHGQIVALLHVYRHFPPVKCLLRVFYRPKATPFQWRNLTFANR 80 Query: 58 LGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNN 117 +GL+AG DK+ C D L +GFG +E+GTVTP GN PR+FRL + L++R GFNN Sbjct: 81 VGLSAGFDKEANCFDELSDLGFGFLEVGTVTPEKVAGNPFPRIFRLPEDHALVSRTGFNN 140 Query: 118 LGVDNLVENVKKAHYDG-VLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSP 176 G + +++N+++ +LG+NI N T E+ D E AYA Y IN S Sbjct: 141 PGKEVVLKNLQRKREGKYILGVNINTNTPTDAERAVTDITDLYETFSAYADYYTINWGS- 199 Query: 177 NTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVR 236 E L D+LTA+++ + P+ +K+ D+ E+L V + Sbjct: 200 --------MTPEILADVLTALESYKQRFHR------PVFLKLPADVPAEKLDTVIEFAKV 245 Query: 237 HNIDGVIATNTTLDRSLVQGMKNCD----QTGGLSGRPLQLKSTEIIRRLSLELNGRLPI 292 H+IDG IAT T DRSL+ + GG+SG P+ KS E+++ LS + + Sbjct: 246 HHIDGFIATGPTQDRSLLIHSAQTEVERVGAGGISGLPVIHKSLEVMKHLSAHAPKDMLL 305 Query: 293 IGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 IG GG+ + A+ AGA LVQ+YS FI++GP ++K I I Sbjct: 306 IGAGGVMTPFEAKAMRNAGAHLVQVYSAFIYEGPGVVKRIAEKI 349 >UniRef50_D0IRU1 Dihydroorotate dehydrogenase n=1 Tax=Helicobacter pylori 51 RepID=D0IRU1_HELP1 Length = 330 Score = 274 bits (700), Expect = 4e-72, Method: Composition-based stats. Identities = 121/315 (38%), Positives = 170/315 (53%), Gaps = 18/315 (5%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPF-----EALVRQKVPAKPVNCMGLTFK 55 M Y ++K LF LD E AHE + L+ ++ +PF ++ K P +GL F Sbjct: 1 MLYSLLKKYLFSLDAEYAHEKVCKILKVLSSSPFLCGLIDSQWGYKNPKLENEILGLHFP 60 Query: 56 NPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGF 115 NPLGLAAG DK+ + AL A GFG +E GT+T Q GN++PRLFR ++ E L N MGF Sbjct: 61 NPLGLAAGFDKNISMLRALIAFGFGYLEAGTLTNAAQSGNERPRLFRHIEEESLQNAMGF 120 Query: 116 NNLGVDNLVENV-KKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINIS 174 NN G + + A Y +GIN+GKNK +DY + K Y N+S Sbjct: 121 NNHGAVLGARSFNRFAPYKTPIGINLGKNKHIEQAHALEDYKAVLNKCLNIGDYYTFNLS 180 Query: 175 SPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSL 234 SPNTP LR LQ +++L K + P+ +KIAPDL +++++V +S Sbjct: 181 SPNTPNLRDLQNKAFVNELFCMAKEMT---------HKPLFLKIAPDLEIDDMLEVVNSA 231 Query: 235 VRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIG 294 + G+IATNTT+D+SLV K + GGLSG+ L KS EI + L+ + ++ Sbjct: 232 IEAGAHGIIATNTTIDKSLVFAPK---EMGGLSGKCLTKKSREIFKELAKAFFNKSVLVS 288 Query: 295 VGGIDSVIAAREKIA 309 VGGI A E+I Sbjct: 289 VGGISDAKDAYERIK 303 >UniRef50_C7NF21 Dihydroorotate oxidase A n=1 Tax=Kytococcus sedentarius DSM 20547 RepID=C7NF21_KYTSD Length = 385 Score = 273 bits (699), Expect = 5e-72, Method: Composition-based stats. Identities = 129/353 (36%), Positives = 184/353 (52%), Gaps = 22/353 (6%) Query: 2 YYPFVRKALFQL---DPERAHEFTFQQLRRITGTP---------FEALVRQKVPAKPVNC 49 Y R LF+L D E AH T Q P L + V C Sbjct: 33 YEHLARPVLFRLGGGDAETAHHTTLQGAAAAARVPGLLHLVAAATGGLAPGQPAGGRVVC 92 Query: 50 MGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGL 109 G+ F + +GLAAG+DKDG + A+G G +E+GTVTPRPQ GN +PR+ RL + + Sbjct: 93 AGVAFGHRVGLAAGVDKDGTALLTWQALGLGHVELGTVTPRPQHGNPRPRVHRLRASRAV 152 Query: 110 INRMGFNNLGVDNLVENVKKAHYDG---VLGINIGKNKDTPVEQGKDDYLICMEKIYAYA 166 +N MGF N GV+ V ++ A +G +G++IGKNKDTP+ + +DY C+ Sbjct: 153 LNAMGFPNAGVEAAVHRLRVARDEGLTIPVGLSIGKNKDTPLARALEDYAACVRVAAGLP 212 Query: 167 GYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHH-KYVPIAVKIAPDLSEE 225 Y+A+NISSPNTPGLR L E L LL + + + VP+ K+APD+ + Sbjct: 213 DYLAVNISSPNTPGLRGLADPEPLRALLAGVVAAERERADAAGTPPVPVLCKVAPDMDDA 272 Query: 226 ELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNC----DQTGGLSGRPLQLKSTEIIRR 281 L + G+IATNTTL R + ++ GG+SG PL ++ E++R Sbjct: 273 ALHAAVGIAQEEGVAGIIATNTTLRRDGLTAEDRAWVGPERPGGVSGAPLTDRAREVVRL 332 Query: 282 LSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVT 334 + LP++GVGG+ + E + AGA LVQ+Y+GFI+ GP L+ I Sbjct: 333 VRAGC--DLPVVGVGGVMTPQDGVELVRAGADLVQVYTGFIYAGPALVAGIAA 383 >UniRef50_B2B417 Predicted CDS Pa_6_7920 n=3 Tax=Sordariomycetes RepID=B2B417_PODAN Length = 482 Score = 271 bits (694), Expect = 2e-71, Method: Composition-based stats. Identities = 118/394 (29%), Positives = 180/394 (45%), Gaps = 64/394 (16%) Query: 4 PFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPA------KPVNCMGLTFKNP 57 P V + LF D E AH L+ + R + VN G+ NP Sbjct: 81 PRVIRVLF-PDAEDAHHAGTAALKALYSVGLHPRERVQDGDATGAKPLAVNVFGVELSNP 139 Query: 58 LGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNN 117 +G++AGLDKD E D L A+G G +E+G +TP PQ GN KPR+FR+V +GLINR G N+ Sbjct: 140 IGISAGLDKDAEIPDPLFALGAGVVEVGGITPLPQEGNPKPRVFRVVSTDGLINRYGLNS 199 Query: 118 LGVDNLVENVKKA---------------------------HYDGVLGINIGKNKDT---P 147 G D + ++++ +L + I KNK T Sbjct: 200 KGADAVAAHLRERLRTFARSIGFTEKEMLDGEAGVPVGSLKDGRLLCVQIAKNKKTDEKD 259 Query: 148 VEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAM 207 VE K DY+ C+ ++ YA + +N+SSPNTPGLR LQ L LL+A+ + + Sbjct: 260 VEAVKKDYVTCVNRLAPYADVLVVNVSSPNTPGLRDLQATGPLTALLSAVVEEAQKTKRK 319 Query: 208 HHKYVPIAVKIAPDLSEE-ELIQVADSLVRHNIDGVIATNTTLDRSLV---------QGM 257 + VK++PD ++ ++ V ++ +DGVI NTT R+ + Q Sbjct: 320 VKPR--VMVKVSPDEDDDSQMEGVVQAVWMSGVDGVIVGNTTKKRTGLVPKGVRLTSQEQ 377 Query: 258 KNCDQTGGLSGRPLQLKSTEIIRRLSLELN---------------GRLPIIGVGGIDSVI 302 KN + GG SG L ++ ++ R L+ + I GGI + Sbjct: 378 KNIMEDGGYSGPALFNQTLNLVGRYRKMLDSYSLKTEGLGDAFNKNQKVIFATGGITNGD 437 Query: 303 AAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 A + + AGAS+ +Y+G ++ G I I + Sbjct: 438 EALKVLNAGASVAMVYTGMVYGGSGTITRIKNEM 471 >UniRef50_C5K5A0 Dihydroorotate dehydrogenase, putative n=2 Tax=Perkinsus marinus ATCC 50983 RepID=C5K5A0_9ALVE Length = 471 Score = 271 bits (694), Expect = 2e-71, Method: Composition-based stats. Identities = 116/395 (29%), Positives = 178/395 (45%), Gaps = 63/395 (15%) Query: 1 MYYPFVRKALFQL---DPERAHEFTFQQLRRITGT------------------------- 32 +Y V LF L DPE AH Sbjct: 56 LYRGLVVPILFPLTASDPEVAHRMAIMGGAVYGRIVFFFHRFWNCLNVYNERVMDRIATI 115 Query: 33 --------PFEALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAM--GFGSI 82 P A+V V G+ F P+GLAAG DK+GE + L + G G Sbjct: 116 LLDGDSRRPACAVVSDDVDPLKQVLFGVEFPRPVGLAAGFDKNGELLHLLTSSTLGNGFA 175 Query: 83 EIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKK-------AHYDGV 135 EIG+V+ P PGN +PR+FRL +INRMG NN G L E ++ + Sbjct: 176 EIGSVSKEPWPGNPRPRMFRLARDGAVINRMGLNNRGAAALREKLRSMSTLLNGTRHTPP 235 Query: 136 LGINIGKNKDTPVEQ--GKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDL 193 +G++I K +E D + +++ YA YI +NIS PNT +T + EAL+ L Sbjct: 236 IGVSITKTPSPTIENDAAIADIVASFDEVAPYAAYIDVNISCPNTAEGKTFEDLEALEKL 295 Query: 194 LTAIKNKQNDLQAMHHKYVPIAVKIAP------DLSEEELIQVADSLVRHNIDGVIATNT 247 L A+ + D ++ P+ VK++P D E + ++ V +DG + NT Sbjct: 296 LGALLTWRRD----NYPDKPVLVKLSPPPAEADDTYYEGVSRMVRKAVELGVDGFVMINT 351 Query: 248 TLDRSLVQ------GMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSV 301 DR G N + GG+SG+P++ ++ ++R + G++PIIG GG+ + Sbjct: 352 IADRGDDLNLDRSVGDSNHGEKGGISGKPVRQRAINLVRHVYKVTAGKVPIIGCGGVFTA 411 Query: 302 IAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 A I GASL+Q+Y+G I++GP + ++I + Sbjct: 412 QDAYRLIRNGASLIQVYTGMIYEGPWVFRDINCGL 446 >UniRef50_D1ZM19 Whole genome shotgun sequence assembly, scaffold_58 n=1 Tax=Sordaria macrospora RepID=D1ZM19_SORMA Length = 753 Score = 271 bits (692), Expect = 3e-71, Method: Composition-based stats. Identities = 112/392 (28%), Positives = 174/392 (44%), Gaps = 61/392 (15%) Query: 4 PFVRKALF--QLDPERAHEFTFQQLRRITGTPFE---ALVRQKVPAKPVNCMGLTFKNPL 58 V + L D E AH L+ + + VN G NP+ Sbjct: 355 YLVPRLLRTIYPDAEEAHHVGTAALKGLYEVGLHIRERVPEYPNGPLSVNVFGKQLLNPI 414 Query: 59 GLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNL 118 G++AGLDKD E D L A+G G +E+G TP PQ GN KPR+FR+ +GLINR G N+ Sbjct: 415 GISAGLDKDAEIPDPLFALGAGVVEVGGCTPFPQEGNPKPRVFRIPTVDGLINRYGLNSR 474 Query: 119 GVDNLVENVKKA-----------------------------HYDGVLGINIGKNKDTPVE 149 G D + +++ H +L + I KNK T + Sbjct: 475 GADAMATRLRERLRKFARSVGLSENQVLNEEGTDDIPPGSLHPGRLLCVQIAKNKKTDEK 534 Query: 150 QG---KDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQA 206 DY+ C++K+ YA + +N+SSPNTPGLR LQ E L LL+A+ + + Sbjct: 535 DVNSVIRDYVYCVDKLAPYADVLVVNVSSPNTPGLRDLQATEPLTKLLSAVVDAAQATKR 594 Query: 207 MHHKYVPIAVKIAPDLSEE-ELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNC----- 260 + + VK++PD + ++ V +++ +DGVI NTT R+ + Sbjct: 595 KNKPR--VMVKVSPDEDDNTQMEGVVEAVWNSGVDGVIVGNTTKRRTGIIPQGVKLIGDE 652 Query: 261 ----DQTGGLSGRPLQLKSTEIIRRLSLELNG------------RLPIIGVGGIDSVIAA 304 + GG SG L ++ ++ R L+G + + GGI + A Sbjct: 653 PEVLHEEGGFSGPALFDRTVSLVGRYRKMLDGYALKNEADKSAAQKVLFATGGITNGEQA 712 Query: 305 REKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + + AGAS+ +Y+G ++ G I I T + Sbjct: 713 LKVLNAGASVAMVYTGMVYGGSGTITRIKTEM 744 >UniRef50_A7BDH3 Putative uncharacterized protein n=1 Tax=Actinomyces odontolyticus ATCC 17982 RepID=A7BDH3_9ACTO Length = 312 Score = 265 bits (678), Expect = 1e-69, Method: Composition-based stats. Identities = 115/298 (38%), Positives = 169/298 (56%), Gaps = 15/298 (5%) Query: 44 AKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRL 103 P+ + LGLAAG+DKD E + + A+G+ +EIGTVTPRPQPGND PRL+RL Sbjct: 22 EVPLTLGERRLPSRLGLAAGMDKDAEAVLGMCALGYAFVEIGTVTPRPQPGNDAPRLWRL 81 Query: 104 VDAEGLINRMGFNNLGVDNLVENVKKAH-----YDGVLGINIGKNKDTPVEQGKDDYLIC 158 ++ GL NRMGFNN G D E +++ ++G NIGKNK T DY C Sbjct: 82 MEERGLRNRMGFNNAGADAAAEKLRELRSTPAGRATIVGANIGKNKVTSEADAPADYEYC 141 Query: 159 MEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKI 218 + + ++ +N+SSPNTPGLR LQ + L +L A + + +P+ VKI Sbjct: 142 ARTLAHWVDFVVVNVSSPNTPGLRDLQSVDHLRPILQAARRGCEA--GAPDRTMPLFVKI 199 Query: 219 APDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEI 278 APDL++E+++ V + + GV+ATNTT++ + GG+SG PL ++ E+ Sbjct: 200 APDLADEDIVAVVELTKELGLAGVVATNTTIN--------HNLGEGGVSGAPLLPRALEV 251 Query: 279 IRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + ++ L+ +IG GGI S A I+AGA LV+ +S FIF+GP E+ + Sbjct: 252 VSLVARHLDDDQILIGTGGISSPEDALRMISAGADLVEAFSAFIFEGPSWPGEVSRAL 309 >UniRef50_Q2H299 Putative uncharacterized protein n=3 Tax=cellular organisms RepID=Q2H299_CHAGB Length = 596 Score = 264 bits (675), Expect = 3e-69, Method: Composition-based stats. Identities = 106/380 (27%), Positives = 172/380 (45%), Gaps = 48/380 (12%) Query: 1 MYYPFVRKALFQL--DPERAHEFTFQQLRRITGTPFEALVRQKVPA----------KPVN 48 ++ V + + L D E AH L+ + R P V Sbjct: 212 IHQWLVPRLIRVLFPDAEDAHHAGTAALKTLYPLGLHPRERPPFPEDAHPATGTNPLAVT 271 Query: 49 CMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEG 108 G T NP+G++AGLDKD E D L A+G G +E+G TP PQ GN +PR+FR+ +G Sbjct: 272 VFGTTLANPIGISAGLDKDAEIADPLFALGAGVVEVGGCTPLPQAGNPRPRVFRVPAVDG 331 Query: 109 LINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDD--------YLICME 160 L+NR G N+ G D + +++ G +G ++ +E G+++ Sbjct: 332 LVNRYGLNSRGADAMAARLRERLRKFARG--LGLSEREVLEAGEEEGGCADGESVAGEAA 389 Query: 161 KIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAP 220 ++ YA + +N+SSPNTPGLR LQ E L LL A+ ++ + + VK++P Sbjct: 390 RLAPYADVLVVNVSSPNTPGLRDLQAAEPLARLLGAVVDEAKRAKRKVKPR--VMVKVSP 447 Query: 221 DLSEE-ELIQVADSLVRHNIDGVIATNTTLDRSLV---------QGMKNCDQTGGLSGRP 270 D ++ ++ V ++ +DGVI NTT R+ + + K + GG SG Sbjct: 448 DEDDDTQMDGVVQAVWMSGVDGVIVGNTTKRRTGLVKEGIKLTGREQKALVEDGGFSGPA 507 Query: 271 LQLKSTEIIRRLSLEL----------NGRLP----IIGVGGIDSVIAAREKIAAGASLVQ 316 + ++ ++ R L N P I GGI + A + + AGAS+ Sbjct: 508 MFDRTLSLVGRYRKMLDSYSLKTSGVNDVFPTPKVIFATGGITNGDQALQVLNAGASVAM 567 Query: 317 IYSGFIFKGPPLIKEIVTHI 336 +Y+G ++ G I I + Sbjct: 568 VYTGMVYGGSGTITRIKKEM 587 >UniRef50_A3ZNL9 Dihydroorotate dehydrogenase n=2 Tax=Planctomycetaceae RepID=A3ZNL9_9PLAN Length = 372 Score = 264 bits (674), Expect = 4e-69, Method: Composition-based stats. Identities = 96/354 (27%), Positives = 158/354 (44%), Gaps = 26/354 (7%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQK-----VPAKPVNCMGLTFK 55 +Y +R LF D E AH T R P + + N GLTF Sbjct: 3 LYRSILRPLLFHWDAETAHHATIAACRIAGAIPLAPQLMRAWYDFAASPLESNVAGLTFP 62 Query: 56 NPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGF 115 NP+GLAAG DK+G + L + GFG EIG+++ GN +PRLFRL ++ G Sbjct: 63 NPVGLAAGWDKNGHALRLLDSWGFGFAEIGSISAAASLGNRRPRLFRLPQDRAIVVNYGL 122 Query: 116 NNLGVDNLVENVKKAHYDGVLGINIGKN------KDTPVEQGKDDYLICMEKIYAYAGYI 169 N G + + + + K LG+N+ K + E+ DDY+ + ++ +A Y+ Sbjct: 123 PNDGAEVIAQRLAKHRIRRPLGVNLVKTNQGPDAAASSAERIVDDYVCSAQAVHRHASYL 182 Query: 170 AINISSPNTPGLRT-LQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELI 228 +N+S PN G + ++ LLTA+ P+ +K+AP+ E+ Sbjct: 183 TLNLSCPNAAGGKDFFAQPGSIRQLLTALL--------PLEIACPLFLKVAPNPDPAEIE 234 Query: 229 QVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQ-----TGGLSGRPLQLKSTEIIRRLS 283 ++ + N + ++ + Q G ++G+P+ S I + Sbjct: 235 RLLEECEPFAAVRGFLFNLPVGKAASLALTTPRQVWEKMPGAVAGQPVAALSNRCIAEMY 294 Query: 284 LELN-GRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + R IIG GG+ S A EK+ GASL+QIY+ +++GP ++ I + Sbjct: 295 QRMPRDRYVIIGGGGVFSAADAYEKMGLGASLIQIYTALVYEGPGVVGRINRGL 348 >UniRef50_UPI00016B255A dihydroorotate dehydrogenase 2 n=4 Tax=candidate division TM7 RepID=UPI00016B255A Length = 394 Score = 258 bits (660), Expect = 2e-67, Method: Composition-based stats. Identities = 99/354 (27%), Positives = 170/354 (48%), Gaps = 26/354 (7%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALV------RQKVPAKPVNCMGLTF 54 +Y ++K LF + P++AH R P L+ + N G+ F Sbjct: 23 LYKNVIKKFLFIIPPDKAHSILVSFARIYQSLPILPLITKFILTHRNNNRLKQNICGINF 82 Query: 55 KNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMG 114 NP+GL+AG DK+ E I + +GFG + G++T P+ GN +P +RL ++ ++ G Sbjct: 83 SNPVGLSAGFDKNIELIPTMSMVGFGYMTGGSITITPRAGNPRPWFYRLPKSKSIVVHAG 142 Query: 115 FNNLGVDNLVENVKKAH-----YDGVLGINIGK---NKDTPVEQGKDDYLICMEKI--YA 164 N G + +++N+K+ + L I+I ++D+ D M + Sbjct: 143 LANDGANIILQNIKRQYKKEANRKIPLFISIAVVARSQDSTEADIIKDVCEAMSLVSGSG 202 Query: 165 YAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSE 224 A + INIS PN + Y + LD+LL+ + D+ PI +K+ + Sbjct: 203 LAKAVEINISCPNIDDNQPFTYPDKLDNLLSQLDKINADM--------PIFIKMPNLVDF 254 Query: 225 EELIQVADSLVRHNIDGVIATNTTLDRSLV--QGMKNCDQTGGLSGRPLQLKSTEIIRRL 282 + + + +H I+GV +N DRS + + GGLSG+P + +S ++I+ Sbjct: 255 VRFGLILEIISKHKINGVTISNLVKDRSNINLKDKLPESVKGGLSGKPCRDRSLDLIKFT 314 Query: 283 SLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + RL IIGVGGI + A KI AG+SLV + +G +F+GP ++ +I + Sbjct: 315 YEKYGDRLLIIGVGGIFNAEDAYLKIRAGSSLVALITGLMFEGPQMVGDINHGL 368 >UniRef50_C6A9A6 Dihydroorotate dehydrogenase 2 n=20 Tax=Bifidobacteriaceae RepID=C6A9A6_BIFLB Length = 386 Score = 250 bits (639), Expect = 5e-65, Method: Composition-based stats. Identities = 104/348 (29%), Positives = 158/348 (45%), Gaps = 22/348 (6%) Query: 2 YYPFVRK-ALFQLDPERAHEFTFQQLRRITGTPF-----EALVRQKVPAKPVNCMGLTFK 55 Y ++ +F P+ AH+ + + P ++ P N MG+ F Sbjct: 28 YKHVIKPDLVFNHTPDIAHDQMIRFCQITGKMPPLMWLCRTMLNYTDPILETNVMGINFA 87 Query: 56 NPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGF 115 NP GL+AGLDK+ + L GFG +G+ T RP GN +P RL + + ++ +G Sbjct: 88 NPFGLSAGLDKNCDMAAVLDHAGFGFETVGSTTSRPCAGNPRPWFHRLPEYDSMMVHVGL 147 Query: 116 NNLGVDNLVENVKKAHYDG---VLGINIGKNKDTPVEQ---GKDDYLICMEKIYAYAGYI 169 N G D ++E + A L ++I + D V G +DY I ME+ + Sbjct: 148 ANDGSDVVIERAEDAWRRTQSMQLSVSIARTNDDQVGDLNEGIEDYCISMERAAGRTAMV 207 Query: 170 AINISSPNTP-GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELI 228 +N+S PNT G + E LD L A+ + P VK+ + + Sbjct: 208 EVNVSCPNTTVGEPFTESAENLDKLFAALDRI--------ERPQPTLVKMPLNKPWPQFK 259 Query: 229 QVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNG 288 + D L HN+ GV N DR+ + + D GGLSG P + STE+IRR E Sbjct: 260 EFLDVLAAHNVQGVTIANLQKDRTGLDDIP-KDWLGGLSGGPCTVASTELIRRTYAEYGD 318 Query: 289 RLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 R I GVGG+ + A EKI AG+SL+ S +++GP I + + Sbjct: 319 RFAIAGVGGVFTPEQAYEKIRAGSSLIMFISSLMYRGPQQITVLKRGL 366 >UniRef50_A2QCB1 Catalytic activity: n=26 Tax=Leotiomyceta RepID=A2QCB1_ASPNC Length = 544 Score = 245 bits (625), Expect = 2e-63, Method: Composition-based stats. Identities = 106/416 (25%), Positives = 167/416 (40%), Gaps = 87/416 (20%) Query: 6 VRKALFQL--DPERAHEFTFQQLRR---ITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 V + L D E AH F L+ P E A G T NP+G+ Sbjct: 127 VVPLVRLLFPDAEDAHHFGVDILKTLYKYGLNPRERGDPDSDGALLTEVFGYTLSNPIGI 186 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 + GLDK + D L +G +E+G TP PQ GN +PR+FRL + +INR G N+ G Sbjct: 187 SGGLDKHADIPDPLFELGPAIVEVGGTTPLPQDGNPRPRVFRLPSQKAMINRYGLNSKGA 246 Query: 121 DNLVENVKKAHYD--------------------------------GVLGINIGKNKDTP- 147 D++ +++ D +L + + KNK TP Sbjct: 247 DHMAAVLEQRVRDYAYAHGFGEHELAEQRVLNGEAGVPPGSLREGKLLAVQVAKNKLTPD 306 Query: 148 --VEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQ 205 +E K DY+ C++++ YA + +N+SSPNTPGLR LQ L +L A+ + Sbjct: 307 NDIEAIKRDYVYCVDRLAKYADILVVNVSSPNTPGLRDLQATAPLTAILKAVVGAAKSID 366 Query: 206 AMHHKYVPIAVKIAPDLS-EEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNC---- 260 + + VK++PD +E++ + D++ +DGVI NTT R Sbjct: 367 RKTKPF--VMVKVSPDEDADEQVSGICDAVWGSGVDGVIVGNTTNRRPEPLPKGFTLPSK 424 Query: 261 -----DQTGGLSGRPLQLKSTEIIRRLS-------------------------------- 283 +TGG SG L ++ ++ R Sbjct: 425 EQDVLKETGGYSGPQLFDRTVALVARYRSLLDASAPAAAAVPKALEAAEPDVENVPPTVS 484 Query: 284 ---LELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 L R I GG+ + AR+ + AGAS+ +Y+ + G + + + Sbjct: 485 EAVEGLPARKVIFASGGVTNGAQARKVLDAGASVAMMYTAITYGGLGTVTRVKEEM 540 >UniRef50_B2V726 Dihydroorotate dehydrogenase n=2 Tax=Aquificales RepID=PYRD_SULSY Length = 311 Score = 237 bits (605), Expect = 4e-61, Method: Composition-based stats. Identities = 78/305 (25%), Positives = 135/305 (44%), Gaps = 31/305 (10%) Query: 42 VPAKPVNCMGLTFKNPLGLAAGLDKDG-ECIDALGAMGFGSIEIGTVTPRPQPGNDKPRL 100 + GL FKNP+ A+G G E G+I + ++ +P+ GN R+ Sbjct: 1 MDKLKHTLFGLEFKNPVWTASGTFSYGLEVAKIYDLSLLGAIVVKGLSLKPRKGNMPERI 60 Query: 101 FRLVDAEGLINRMGFNNLGVDNLVENV--KKAHYDGVLGINIGKNKDTPVEQGKDDYLIC 158 G++N +G N GVD + K YD + N+ + +D+YL Sbjct: 61 VE--TPAGMLNSIGLQNPGVDYFINETLPKLKKYDTKIFANVFG-------EDEDEYLAV 111 Query: 159 MEKI--YAYAGYIAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPI 214 E++ + +N+S PN G+ E L +L+ +K P+ Sbjct: 112 AERLDKADGVHGLELNVSCPNVKKGGIAFGTDPEVLYNLVYKMKKITK---------KPL 162 Query: 215 AVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLV---QGMKNCDQTGGLSGRPL 271 VK++P++S ++ AD+ V DG++ NT L ++ + TGGLSG + Sbjct: 163 LVKLSPNVS--NILDTADACVSAGADGLVLINTLLGVAIDVEREKPILSTITGGLSGPAM 220 Query: 272 QLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKE 331 + +I ++ + R+PIIGVGGI + A + I AGAS +Q+ + + P + Sbjct: 221 LPIAVRMIWQVYQKYGSRIPIIGVGGISNYKDALQHILAGASAIQVGTANFY-DPLSPLK 279 Query: 332 IVTHI 336 I+ + Sbjct: 280 IIEDL 284 >UniRef50_C0QU30 Dihydroorotate dehydrogenase, catalytic subunit (Dihydroorotate oxidase) (Dhodehase) (Dhodase) (Dhod) n=3 Tax=Hydrogenothermaceae RepID=C0QU30_PERMH Length = 320 Score = 237 bits (604), Expect = 6e-61, Method: Composition-based stats. Identities = 75/303 (24%), Positives = 136/303 (44%), Gaps = 32/303 (10%) Query: 45 KPVNCMGLTFKNPLGLAAGLDKDG-ECIDALGA-MGFGSIEIGTVTPRPQPGNDKPRLFR 102 G+ FKNP+ A+G G E L G++ + ++ RP+ GN R+ Sbjct: 12 LSYELFGIKFKNPVWTASGCFSYGLEVAQNLYDISELGAVVVKGLSYRPREGNPPQRIVE 71 Query: 103 LVDAEGLINRMGFNNLGVDNLVENVKK--AHYDGVLGINIGKNKDTPVEQGKDDYLICME 160 G++N +G N GV+ ++N+ YD V+ N+ + +D+YL E Sbjct: 72 --TPCGMLNSIGLQNPGVEYFIKNILPQLREYDTVIVANVFG-------EDEDEYLKVAE 122 Query: 161 KI--YAYAGYIAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAV 216 + + +N+S PN G+ E L +L+ +K P+ V Sbjct: 123 VLNKADGVDLLELNVSCPNVKKGGIAFGSDPETLFNLVYRLKQVME---------KPLLV 173 Query: 217 KIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKN---CDQTGGLSGRPLQL 273 K++P++++ ++ A + V DG++ NT L ++ + +TGGLSG + Sbjct: 174 KLSPNITD--ILDTATASVEAGADGLVLINTLLGMAIDIDKEEPIIGMRTGGLSGPAILP 231 Query: 274 KSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIV 333 + +I ++ + +PIIGVGGI + A + I AGA VQI + + P +++ Sbjct: 232 VAVRMIYQVYEKYGSSVPIIGVGGITTAQDALQHILAGAVSVQIGTANFY-DPYSPLKVI 290 Query: 334 THI 336 + Sbjct: 291 KGL 293 >UniRef50_O27281 Dihydroorotate dehydrogenase n=20 Tax=Euryarchaeota RepID=PYRD_METTH Length = 303 Score = 231 bits (589), Expect = 3e-59, Method: Composition-based stats. Identities = 63/300 (21%), Positives = 128/300 (42%), Gaps = 30/300 (10%) Query: 45 KPVNCMGLTFKNPLGLAAGLDKD-GECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRL 103 + + +NP LAAG+ ++ + G G++ + + RP PG P + Sbjct: 5 LETSICNIELRNPTILAAGVMGSMASSLNRIYRGGAGAVVTKSFSLRPNPGYRNPTTVEV 64 Query: 104 VDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIY 163 G+IN +G +N GV+ E +K + L ++ +++ + Sbjct: 65 --TGGVINAIGLSNPGVEAFREELKLVDEEVPLIASV-------YGASPEEFASAAASVE 115 Query: 164 AYAGYIAINISSPNTP---GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAP 220 YA I +N+S P+ G Q E +++A+K+ + VPI+ K+ P Sbjct: 116 EYADMIELNVSCPHAMAGCGASIGQDPELTFRVVSAVKDAVD---------VPISTKLTP 166 Query: 221 DLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQ----GMKNCDQTGGLSGRPLQLKST 276 ++++ ++++A S D + N+ + + GG+SG ++ + Sbjct: 167 NVTD--IVEIAGSAEEAGSDALTLINSLGPGMKIDIKTARPILSNAFGGMSGPAIKPVAV 224 Query: 277 EIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + + + +PI+GVGG+ A E + AGA VQ+ + ++ GP + +I + Sbjct: 225 RCVYDVYRSV--DIPIMGVGGVRDFQDAVEFLFAGARAVQVGTAIMYDGPEVFMKICRGL 282 >UniRef50_B0TGQ8 Dihydroorotate dehydrogenase n=32 Tax=Bacteria RepID=PYRD_HELMI Length = 309 Score = 229 bits (585), Expect = 9e-59, Method: Composition-based stats. Identities = 68/302 (22%), Positives = 129/302 (42%), Gaps = 33/302 (10%) Query: 45 KPVNCMGLTFKNPLGLAAGLDKDG-ECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRL 103 VN GLT KNP+ A+G G E + G+I + T P+ GN PR+ Sbjct: 6 LQVNLGGLTMKNPVTTASGTFGFGLEFAPFIDLSRLGAIVVKGTTLEPREGNPTPRMAE- 64 Query: 104 VDAEGLINRMGFNNLGVDNLVENVKK--AHYDGVLGINIGKNKDTPVEQGKDDYLICMEK 161 G++N +G N GV+ + + D + +N+ N +DY Sbjct: 65 -TPAGMLNAIGLQNPGVEAFIRDYLPPLRQIDTPVIVNVSGN-------SVEDYGRLASI 116 Query: 162 I--YAYAGYIAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVK 217 + + +NIS PN G++ + + A++ + P+ VK Sbjct: 117 LDEADGVAALEVNISCPNVKEGGIQFGTLPASAAAVTRAVRE---------NTQKPVIVK 167 Query: 218 IAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLV---QGMKNCDQTGGLSGRPLQLK 274 ++P++++ + ++A ++V D + NT L + + + GGLSG ++ Sbjct: 168 LSPNVTD--ITEMARAVVDAGADALALINTLLGMDIDICTRRPVLANIFGGLSGPAIKPV 225 Query: 275 STEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVT 334 + +I ++ + +PI+G+GGI + A + AGA+ + + + F P +I+ Sbjct: 226 ALRMIYQVYRAV--HVPILGMGGIMNSQDAIAFMLAGATAIAVGTAN-FTNPRATMDILE 282 Query: 335 HI 336 I Sbjct: 283 GI 284 >UniRef50_A4IM35 Dihydroorotate dehydrogenase n=348 Tax=Bacteria RepID=PYRD_GEOTN Length = 313 Score = 227 bits (580), Expect = 3e-58, Method: Composition-based stats. Identities = 72/305 (23%), Positives = 128/305 (41%), Gaps = 33/305 (10%) Query: 42 VPAKPVNCMGLTFKNPLGLAAGLDKDG-ECIDALGAMGFGSIEIGTVTPRPQPGNDKPRL 100 + V GL+ KNP+ A+G G E G+I I T P+ GN PR+ Sbjct: 1 MNRLAVELPGLSLKNPIMPASGCFGFGREYAQFYDLSVLGAIMIKATTKEPRFGNSTPRV 60 Query: 101 FRLVDAEGLINRMGFNNLGVDNLVENVKK--AHYDGVLGINIGKNKDTPVEQGKDDYLIC 158 G++N +G N G+D ++ +D + NI + ++Y+ Sbjct: 61 AE--TPSGMLNAIGLQNPGLDKVLAEELPWLEQFDVPIIANIAGS-------TMEEYVEV 111 Query: 159 MEKI--YAYAGYIAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPI 214 I + +NIS PN G+ E +L +K VP+ Sbjct: 112 AAAISKAPNVHALELNISCPNVKKGGIAFGTVPEVAAELTRLVKEV---------SAVPV 162 Query: 215 AVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKN---CDQTGGLSGRPL 271 VK++P++++ ++ +A ++ + DG+ NT + + + TGGLSG + Sbjct: 163 YVKLSPNVTD--IVAMAKAIEQAGADGLTMINTLVGMRIDVKTGRPILANGTGGLSGPAV 220 Query: 272 QLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKE 331 + + +I +S ++ PIIG+GG+ + E AGAS V + + F P + Sbjct: 221 KPIAVRMIYEVSQAVSI--PIIGMGGVQTAEDVLEFFYAGASAVAVGTAN-FIDPFVCPT 277 Query: 332 IVTHI 336 I+ + Sbjct: 278 IINEL 282 >UniRef50_Q4N5X1 Dihydroorotate dehydrogenase, putative n=1 Tax=Theileria parva RepID=Q4N5X1_THEPA Length = 291 Score = 227 bits (580), Expect = 3e-58, Method: Composition-based stats. Identities = 110/332 (33%), Positives = 158/332 (47%), Gaps = 65/332 (19%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 +Y + LDPE +H+ + L ++ TP + + P N + NP+G+ Sbjct: 16 IYDGILYGLRKCLDPEESHKLSI-VLAKLGLTPVDYSI--DPPILYNNIKHIKIFNPIGM 72 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAG DK+ + + +GFG IE+GTV P PQPGN KPRLFRL + + LIN +GFN+LG+ Sbjct: 73 AAGYDKNCQVPLEILRLGFGFIEVGTVLPNPQPGNPKPRLFRLPNNKALINSLGFNSLGI 132 Query: 121 DNLVENVKKAH---------YDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAI 171 D VEN+K A D ++GI+IGKN + + D C+E+I Y+ Y+ I Sbjct: 133 DVAVENMKVARARQESDPLTRDSIIGISIGKNLN---GEILADVSHCIERIGLYSDYLCI 189 Query: 172 NISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVA 231 N+SSPNTP LR Q E L L+ KN DL+ PD++++EL +A Sbjct: 190 NVSSPNTPNLRDNQRKEPLLKLVKTAKNALKDLETRVSTENLTY----PDVTDQELKDIA 245 Query: 232 DSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLP 291 D + H +DG++ TNTT Sbjct: 246 DIALEHGLDGLVLTNTT------------------------------------------- 262 Query: 292 IIGVGGIDSVIAAREKIAAGASLVQIYSGFIF 323 GGI + A E I AGAS Q+ +G + Sbjct: 263 ---CGGISTAQDALEMIEAGASACQLLTGLVR 291 >UniRef50_Q2NEG1 PyrD n=1 Tax=Methanosphaera stadtmanae DSM 3091 RepID=Q2NEG1_METST Length = 306 Score = 225 bits (573), Expect = 2e-57, Method: Composition-based stats. Identities = 63/303 (20%), Positives = 129/303 (42%), Gaps = 32/303 (10%) Query: 45 KPVNCMGLTFKNPLGLAAGLDKD-GECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRL 103 +G+ NPL LAAG+ + + G G I + + G D P + ++ Sbjct: 2 LEQEILGMKLSNPLFLAAGILGTTASSMKMVARAGAGGIVTKSFSIEANDGYDNPTIVKI 61 Query: 104 VDAEGLINRMGFNNLGVDNLVENVK---KAHYDGVLGINIGKNKDTPVEQGKDDYLICME 160 G+IN +G + GV+ E +K + + +I ++ + Sbjct: 62 --EGGVINSVGLASPGVEAKKEELKDLNEIRDKTPVIASI-------YGDSEEVFSDVAN 112 Query: 161 KIYAYAGYIAINISSPNTP---GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVK 217 + Y +N+S P+ G + E D+++++K+ + K VPI VK Sbjct: 113 QTKDYVDAFELNVSCPHAKCGFGSNIGENPELTHDIVSSVKD--------NIKDVPIIVK 164 Query: 218 IAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQ----GMKNCDQTGGLSGRPLQL 273 + P++++ + ++A + D + N+ + + GG++G ++ Sbjct: 165 LTPNVTD--ITEIAKAAEDAGADALTLINSVGPGLRIDYKTARPILNNVFGGIAGPMIKP 222 Query: 274 KSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIV 333 + + + + + +P+ GVGGI + A E + AGASL+QI + +++GP + K I Sbjct: 223 IALKCVYKTYETV--DIPLFGVGGIRTYKDALEFLYAGASLLQIGTSIMYEGPEIFKNIT 280 Query: 334 THI 336 + Sbjct: 281 HDL 283 >UniRef50_A6L5H1 Dihydroorotate dehydrogenase n=7 Tax=Bacteroidales RepID=PYRD_BACV8 Length = 303 Score = 225 bits (573), Expect = 2e-57, Method: Composition-based stats. Identities = 70/305 (22%), Positives = 131/305 (42%), Gaps = 33/305 (10%) Query: 42 VPAKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMG-FGSIEIGTVTPRPQPGNDKPRL 100 + VN L NP+ A+G G+ + + G I + T + GN PR+ Sbjct: 1 MADLSVNIGDLKLCNPVMTASGTFGYGKEFEDFVDLEKIGGIIVKGTTLHHREGNPYPRM 60 Query: 101 FRLVDAEGLINRMGFNNLGVDNLVENVKKAHYDG--VLGINIGKNKDTPVEQGKDDYLIC 158 G++N +G N GVD VE++ D + +N+ + +DY+ Sbjct: 61 AE--TPMGMLNAVGLQNKGVDYFVEHIYPQIRDIHTNMIVNVSGS-------AVEDYVKT 111 Query: 159 MEKIYA--YAGYIAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPI 214 E I + I +NIS PN G+ +++ A++N + Sbjct: 112 AEIINDLDHIPAIELNISCPNVKQGGMAFGVSACGCSEVVKAVRNV---------YKKTL 162 Query: 215 AVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLV---QGMKNCDQTGGLSGRPL 271 VK++P++++ + ++A + D V NT L ++ + TGG+SG + Sbjct: 163 IVKLSPNVTD--ITEIARAAEASGADSVSLINTLLGMAVDAEKRRPVLSTITGGMSGAAV 220 Query: 272 QLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKE 331 + + ++ +++ +N P+IG+GGI A E + AGA+ +QI + F P + + Sbjct: 221 KPIALRMVWQVAKAVNI--PVIGLGGIMGWKDAVEFMLAGATAIQIGTAN-FIDPAITVK 277 Query: 332 IVTHI 336 + I Sbjct: 278 VSEGI 282 >UniRef50_Q979G6 Dihydroorotate dehydrogenase n=4 Tax=Thermoplasmatales RepID=PYRD_THEVO Length = 301 Score = 224 bits (572), Expect = 3e-57, Method: Composition-based stats. Identities = 70/298 (23%), Positives = 126/298 (42%), Gaps = 30/298 (10%) Query: 42 VPAKPVNCMGLTFKNPLGLAAG-LDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRL 100 + G+ NP +A+G LD++G + L G ++ ++ + G P + Sbjct: 1 MSDISTTLAGIKLVNPFMVASGILDENGYTMKELLERGAAAVVTKSIGISERDGYPTPVI 60 Query: 101 FRLVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICME 160 D LIN +G +N G++N E + A I + +++ Sbjct: 61 VEYGD--SLINAVGLSNPGIENFGEEINIAKEAKRPII------GSVFAYNAEEFTKLSV 112 Query: 161 KIYAYA-GYIAINISSPNTPG--LRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVK 217 K+ Y I +N+S P+ G L + ++D++ IK+K VP+ K Sbjct: 113 KMEEYGVDAIELNLSCPHVKGFGLEVGSDPDLVEDIVNEIKSKVK---------VPVFAK 163 Query: 218 IAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLV---QGMKNCDQTGGLSGRPLQLK 274 ++P++S +I++A + + D + NT ++ + + GGLSG ++ Sbjct: 164 LSPNVS--NIIEIAKAAEK--ADAYVLINTVKAMAIDIYSRSPVLSNLYGGLSGPAIKPV 219 Query: 275 STEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 + + E IIGVGGI + A E I AGAS VQI + G + +E+ Sbjct: 220 GIRYVYEVKKETGKE--IIGVGGISNYKDAIEYIMAGASAVQIGTALYKYGKGIFREM 275 >UniRef50_A9A3M4 Dihydroorotate dehydrogenase family protein n=2 Tax=Thaumarchaeota RepID=A9A3M4_NITMS Length = 303 Score = 224 bits (571), Expect = 4e-57, Method: Composition-based stats. Identities = 68/300 (22%), Positives = 122/300 (40%), Gaps = 27/300 (9%) Query: 43 PAKPVNCMGLTFKNPLGLAAGLDK-DGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLF 101 P + + P+ LA+G+ + L G G++ +++ P G P +F Sbjct: 3 PNLATSIGPIQLDRPVMLASGILGISLDVFSRLYRSGAGAVVTKSLSTEPWEGYPNPTIF 62 Query: 102 RLVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEK 161 + G IN +G +N G +N + ++ D + +++ + E+ + C Sbjct: 63 SV-KGGGWINAVGLSNPGAENFAKMIEPN-QDVPIIVSLVGSIPEDFEKMIKQFENC--- 117 Query: 162 IYAYAGYIAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIA 219 +N+S P+ GL E + ++T +KN N VP+ K+ Sbjct: 118 ---KVTAYELNLSCPHVAKVGLEVGDDPELVKKIVTTVKNSTN---------VPVIAKVG 165 Query: 220 PDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLV---QGMKNCDQTGGLSGRPLQLKST 276 + + + + ID + A NT ++ Q ++ GGLSG P++ + Sbjct: 166 LGTT--HYLNTVGTAIESGIDAITAINTVRSMAIDVETQRPILSNKFGGLSGTPIKPIAL 223 Query: 277 EIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + +S + +PIIG GGI + A E AGAS VQ+ S + EI T I Sbjct: 224 RCVYEISSKY--DIPIIGCGGISTWEDAVEFFLAGASSVQLGSAIGDNWIDVFNEINTGI 281 >UniRef50_B5YFH3 Dihydroorotate dehydrogenase n=2 Tax=Dictyoglomus RepID=B5YFH3_DICT6 Length = 306 Score = 222 bits (567), Expect = 1e-56, Method: Composition-based stats. Identities = 71/299 (23%), Positives = 124/299 (41%), Gaps = 24/299 (8%) Query: 42 VPAKPVNCMGLTFKNPLGLAAGLDKDGECIDALGA-MGFGSIEIGTVTPRPQPGNDKPRL 100 + V L FKNP+ LA+G +G I+ G G ++T P+ GN PR+ Sbjct: 1 MNNLEVRIGSLIFKNPILLASGTCGNGREINKFYDINGLGGFVTKSITLNPREGNPPPRI 60 Query: 101 FRLVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICME 160 + G++N +G N+G+ +E + + L N+ + + K++Y Sbjct: 61 WE--SYAGILNSIGLENVGLQKFLEE--EMPFLERLSTNVIVS---IAGEKKEEYYEIAR 113 Query: 161 KI-YAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIA 219 + + +N+S PN G G +K + K P+ VK+ Sbjct: 114 NLRGCKISGVELNLSCPNVEG-----GGMLFGIDKEMVKEITKKVVKEIGK--PVWVKLT 166 Query: 220 PDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKN---CDQTGGLSGRPLQLKST 276 P ++++++ ++ + V+ NT L ++ + G SG ++ Sbjct: 167 PQ--AKDIVEIVKAVKDAGGEAVVLFNTFLGLAIDWKKRKPVFKRIFAGYSGPAVKPLVL 224 Query: 277 EIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTH 335 + + E LPI+G GGI S E I AGASLVQI S F+ P + + +V Sbjct: 225 RYVWEVYEE--NLLPIVGCGGIVSFSDVLEYIFAGASLVQIGSAN-FRDPWIGERLVKE 280 >UniRef50_UPI00016B240E dihydroorotate dehydrogenase 2 n=1 Tax=candidate division TM7 single-cell isolate TM7c RepID=UPI00016B240E Length = 338 Score = 222 bits (566), Expect = 1e-56, Method: Composition-based stats. Identities = 92/317 (29%), Positives = 140/317 (44%), Gaps = 26/317 (8%) Query: 37 LVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGND 96 + + + G+ F+NP+GL+AG DK+ + + +GFG G+VT P+ GN Sbjct: 1 MWSFRDKSLQQEIDGVNFRNPIGLSAGFDKNVQLSPLMEDVGFGFASGGSVTLEPRKGNL 60 Query: 97 KPRLFRLVDAEGLINRMGFNNLGVDNL-----VENVKKAHYDGVLGINIGKNKDT----- 146 +P RL + ++ G N G++ + +K V+ + + NK T Sbjct: 61 RPWFHRLPKTKSVVVYAGMPNYGLEKIGNYVKANRIKIQSMPTVVSVAVVANKSTKDKLG 120 Query: 147 ---PVEQGKDDYLICMEKIYA--YAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQ 201 P E D + I A + INIS PN G + Y E L+ LL I Sbjct: 121 PKVPEEYIVKDVKKAVNYIIDNKLASIVEINISCPN-AGKESFIYPETLEILLKEIDTI- 178 Query: 202 NDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQ--GMKN 259 + +P +K+ + + +V+HNI GV N DR+ V+ Sbjct: 179 -------DRNIPFWIKMPHLYDINQFDSLLKVIVKHNIQGVTIANLVKDRTKVEIKDPLT 231 Query: 260 CDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYS 319 + GGLSG P + S E+IR +L I+GVGGI S A KI AGASLV + + Sbjct: 232 DEIRGGLSGEPTRKHSLELIRYAYKNYGNKLTIVGVGGIFSAEDAYAKIKAGASLVGLIT 291 Query: 320 GFIFKGPPLIKEIVTHI 336 G F+GP L+ + Sbjct: 292 GLFFEGPHLVGRANREL 308 >UniRef50_Q3AC05 Dihydroorotate dehydrogenase n=1 Tax=Carboxydothermus hydrogenoformans Z-2901 RepID=PYRD_CARHZ Length = 307 Score = 222 bits (565), Expect = 2e-56, Method: Composition-based stats. Identities = 69/302 (22%), Positives = 130/302 (43%), Gaps = 33/302 (10%) Query: 45 KPVNCMGLTFKNPLGLAAGLDKDG-ECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRL 103 V LT KNP+ A+G G E D G++ + T+T P+ GN PR++ + Sbjct: 3 LKVKIGELTLKNPVMPASGTFGFGLEFKDIFDLKNLGALVVKTITKNPRLGNRPPRVYEV 62 Query: 104 VDAEGLINRMGFNNLGVDNLVENVKKAHYDG--VLGINIGKNKDTPVEQGKDDYLICMEK 161 G+IN +G N G D E + D +L +NI + +++ + Sbjct: 63 S--CGMINSIGLANPGWDYFCEKILPQIKDLNDILILNIAG-------ESVEEFQYLARE 113 Query: 162 IYAYAGY--IAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVK 217 + + +N+S PN G+ EAL ++++++ + VK Sbjct: 114 AQRFDEIKALELNVSCPNVSKGGIAFGTDLEALKQIVSSVRKI---------YSKTLIVK 164 Query: 218 IAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLV---QGMKNCDQTGGLSGRPLQLK 274 + P++++ + A + D + NT + + ++ GG+SG ++ Sbjct: 165 LTPNVTD--ITVYAKAAENAGADALTLINTFTGMVIDVKSKKPILGNKHGGVSGPAIRPM 222 Query: 275 STEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVT 334 + +++ ++ PIIGVGGIDS AA E AGA+ +Q+ S + P + ++ Sbjct: 223 AVKMVYDCFKAVSI--PIIGVGGIDSKEAALEFFLAGATAIQVGSQNFVE-PGFMPRLIR 279 Query: 335 HI 336 + Sbjct: 280 EL 281 >UniRef50_C9KKE5 Dihydroorotate oxidase n=6 Tax=Bacteria RepID=C9KKE5_9FIRM Length = 316 Score = 220 bits (562), Expect = 4e-56, Method: Composition-based stats. Identities = 70/305 (22%), Positives = 129/305 (42%), Gaps = 32/305 (10%) Query: 41 KVPAKPVNCMGLTFKNPLGLAAGLDKDGE-CIDALGAMGFGSIEIGTVTPRPQPGNDKPR 99 N +G+ + P+ A+G GE D + G + + T P+ GND R Sbjct: 2 SDERLHTNLLGIAMQTPVLTASGTFGFGEEFADFVDLSRLGGVMVKGTTLLPRRGNDGVR 61 Query: 100 LFRLVDAEGLINRMGFNNLGVDNLVENVKKA--HYDGVLGINIGKNKDTPVEQGKDDYLI 157 + +G++N +G N GV++ ++ Y + +NI + +DY Sbjct: 62 ITE--TPKGMLNCIGLENPGVEHFLKETLPRIQQYGMNVIVNISGS-------TAEDYGK 112 Query: 158 CMEKIY-AYAGYIAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPI 214 + I +N+S PN G+ EA ++ A K H P+ Sbjct: 113 LAGLLDVPGVAAIELNVSCPNVKEGGIVFGTDPEAASAVVRAAKA---------HTKKPV 163 Query: 215 AVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKN---CDQTGGLSGRPL 271 +K++P++++ ++ +A ++ D V NT L + + TGGLSG + Sbjct: 164 ILKLSPNVTD--IVAMAKAVEAAGADAVSLINTLLGMEIDIHRFRPVLGNITGGLSGPCV 221 Query: 272 QLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKE 331 + + ++ +++ + +PIIG+GGI S A E AGAS V + + F P + + Sbjct: 222 KPVAVRMVWQVAQAV--HIPIIGMGGIASAEDAVEFFLAGASAVAVGTAN-FTDPEITMK 278 Query: 332 IVTHI 336 I + Sbjct: 279 ICDGL 283 >UniRef50_A9BJH4 Dihydroorotate dehydrogenase n=45 Tax=Bacteria RepID=PYRD_PETMO Length = 300 Score = 220 bits (561), Expect = 5e-56, Method: Composition-based stats. Identities = 81/304 (26%), Positives = 134/304 (44%), Gaps = 32/304 (10%) Query: 42 VPAKPVNCMGLTFKNPLGLAAGLDKDG-ECIDALGAMGFGSIEIGTVTPRPQPGNDKPRL 100 + VN G+ FKNP+ A+G G E ++ G + +T R + GN R+ Sbjct: 1 MIDTKVNIAGVEFKNPVIAASGTFGFGREFLEYFPISKLGGLATKGLTLREREGNKGVRI 60 Query: 101 FRLVDAEGLINRMGFNNLGVDNLVENVKK--AHYDGVLGINIGKNKDTPVEQGKDDYLIC 158 + G++N +G N G+D +E D V+ N+ N D+Y+I Sbjct: 61 HETI--GGIMNSIGLQNPGIDAFIEEELPFLNSQDTVIIANVSGN-------TIDEYVIS 111 Query: 159 MEKIYA-YAGYIAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIA 215 +EK+ I +NIS PN G+ E +++T ++ P+ Sbjct: 112 VEKLNQTDIDMIELNISCPNVKEGGISFGTKAEIASNVVTQVRKVCQ---------KPLI 162 Query: 216 VKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNC---DQTGGLSGRPLQ 272 VK++P S E ++++A+S V D + NT ++ K + T GLSG ++ Sbjct: 163 VKLSP--SAENIVEMAESCVEAGADALSLVNTFPALAIDISKKKAIFDNITAGLSGPCIK 220 Query: 273 LKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 + ++ +S + +PIIG+GGI A E I AGA VQ+ + F P EI Sbjct: 221 PIALRMVYEVSKAV--DVPIIGIGGIMDYRDAIEYIMAGAWAVQVGTAN-FINPNACAEI 277 Query: 333 VTHI 336 + I Sbjct: 278 IEGI 281 >UniRef50_Q1G992 Dihydroorotate dehydrogenase n=3 Tax=Lactobacillus delbrueckii RepID=Q1G992_LACDA Length = 309 Score = 219 bits (559), Expect = 8e-56, Method: Composition-based stats. Identities = 78/302 (25%), Positives = 138/302 (45%), Gaps = 33/302 (10%) Query: 45 KPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLV 104 V GL KNP+ A+G G+ + G+I + T T + GN +P++ L Sbjct: 7 LAVELPGLKLKNPVMPASGTFAFGDLPENFNWDEMGAIVLKTATRHARTGNPQPQIDLLA 66 Query: 105 DAEGLINRMGFNNLGVDNLVEN----VKKAHYDGVLGINIGKNKDTPVEQGKDDYLICME 160 D G++N +G N G + + +++ H D + ++G + +DY+ E Sbjct: 67 D--GVMNAVGLTNPGAEVVASEKIPALREKHPDLPILASVGG-------ESVEDYVEVAE 117 Query: 161 KIYAY-AGYIAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVK 217 + A + +N+S PN G+ E L+ + +K K + +P+ VK Sbjct: 118 ILAAAKPDALELNLSCPNVSEGGMTFGIVPEMLEKITRLVKEKVD---------LPVYVK 168 Query: 218 IAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKN---CDQTGGLSGRPLQLK 274 + P+++ ++++A + DG+ NT L L + + GGL G+ ++ Sbjct: 169 LTPNVTS--IVEIAQAAEGGGADGLTLINTLLVLHLDLKTRRPVLGNDFGGLYGQAVKPV 226 Query: 275 STEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVT 334 + ++ ++ + LPIIGVGGI+S A E I AGAS VQI S F IK ++ Sbjct: 227 AVRMVAQVKQATS--LPIIGVGGINSPEDAAEFILAGASAVQIGS-MSFYDKLAIKHVID 283 Query: 335 HI 336 + Sbjct: 284 GL 285 >UniRef50_C0QYH6 Dihydroorotate dehydrogenase n=2 Tax=Brachyspira RepID=PYRD_BRAHW Length = 303 Score = 218 bits (556), Expect = 2e-55, Method: Composition-based stats. Identities = 73/304 (24%), Positives = 132/304 (43%), Gaps = 31/304 (10%) Query: 42 VPAKPVNCMGLTFKNPLGLAAGLDKDGECIDALGA-MGFGSIEIGTVTPRPQPGNDKPRL 100 + +N +G KN + ++G GE G++ + +T + GN R+ Sbjct: 1 MSRLNINFLGKELKNNVITSSGCFGFGEEYSNYFDVNELGAVNLKGITLNKKDGNKGTRI 60 Query: 101 FRLVDAEGLINRMGFNNLGVDNLVENV-KKAHYDGVLGINIGKNKDTPVEQGKDDYLICM 159 G+IN +G N G++ +N+ K Y + +NI D+Y+ Sbjct: 61 AE--TPSGMINCIGLENPGIEYFKDNIIKNIKYSTPIILNI-------NGATIDEYVKVA 111 Query: 160 EKIYAY--AGYIAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIA 215 E ++ +NIS PN G+ E+ + A+K P+ Sbjct: 112 EIANEIERVDFVELNISCPNVKNGGMAFGASCESAESTTKAVKKVL--------SKKPLI 163 Query: 216 VKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKN---CDQTGGLSGRPLQ 272 VK++P++++ + +A ++ D V NT L + + + GGLSG ++ Sbjct: 164 VKLSPNVTD--IASIAKAVEDAGADSVSLVNTFLSMKIDTKTRKPLLGNIFGGLSGACIR 221 Query: 273 LKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 + ++ ++ + ++PI+G+GGI + A E I AGASLV I +G IF P L E+ Sbjct: 222 PIAVRMVYQVYKAV--KIPIVGMGGITNYNDALEFILAGASLVSIGAG-IFSNPILPIEV 278 Query: 333 VTHI 336 + I Sbjct: 279 INGI 282 >UniRef50_Q0W8E1 Dihydroorotate dehydrogenase n=18 Tax=Euryarchaeota RepID=PYRD_UNCMA Length = 301 Score = 217 bits (554), Expect = 4e-55, Method: Composition-based stats. Identities = 73/299 (24%), Positives = 129/299 (43%), Gaps = 31/299 (10%) Query: 45 KPVNCMGLTFKNPLGLAAGLDKD-GECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRL 103 N GLT KNP LAAG+ G + + +MG G++ ++ P+PG+ P + RL Sbjct: 3 ITCNAGGLTLKNPTILAAGVLGTTGASLKRIASMGAGAVVTKSIGTEPKPGHHNPSMIRL 62 Query: 104 VDAEGLINRMGFNNLGVDNLVENVKKAHYDG-VLGINIGKNKDTPVEQGKDDYLICMEKI 162 EG IN MG N + ++ A G + +I +++ + Sbjct: 63 --EEGYINAMGLPNPSFGEFRQELEIARESGVPVIASIFGATP-------EEFTAVANGL 113 Query: 163 YAYAGYIAINISSPNTPG--LRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAP 220 A +N+S P+ G ++ E + + A+K VP+ VK+ P Sbjct: 114 -PGADAYELNVSCPHAKGYGMQCGTDPELVRSITKAVKAAVK---------VPVWVKLTP 163 Query: 221 DLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMK---NCDQTGGLSGRPLQLKSTE 277 ++++ I +A D V+A NT ++ +++GGLSG ++ + + Sbjct: 164 NVTDIRPIGLA--AQEGGADAVVAINTLKAMAIDINTGWPILGNRSGGLSGPAVKPVAIK 221 Query: 278 IIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + L L +P+IGVGG+ + A E + AGA V+I S +++ + I Sbjct: 222 CVYDLYEVL--DIPVIGVGGVSNWADAIEFMMAGACAVEIGSA-VYEDIGTFASVSMGI 277 >UniRef50_B5YJH1 Dihydroorotate dehydrogenase n=24 Tax=Bacteria RepID=PYRD_THEYD Length = 303 Score = 217 bits (553), Expect = 4e-55, Method: Composition-based stats. Identities = 75/303 (24%), Positives = 130/303 (42%), Gaps = 29/303 (9%) Query: 42 VPAKPVNCMGLTFKNPLGLAAGLDKDG-ECIDALGAMGFGSIEIGTVTPRPQPGNDKPRL 100 +P V L+FKNP+ A+G G E + G I + ++ +P+ GN PR+ Sbjct: 1 MPVLEVKIGNLSFKNPVLTASGTFGYGLEYSQFVDLNILGGIVVKGLSLKPKQGNPPPRI 60 Query: 101 FRLVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICME 160 + G+IN +G N+G++ + K + NI N + D+Y+ + Sbjct: 61 YE--TPCGMINSIGLQNIGLEAFKKE--KLPFLKKFNTNIIVNF---FGENLDEYIEVAK 113 Query: 161 KIYA--YAGYIAINISSPN-TPGLRTLQ-YGEALDDLLTAIKNKQNDLQAMHHKYVPIAV 216 + + +N+S PN T R + E L + + ++ H P+ V Sbjct: 114 LLDETEGVHALEMNVSCPNKTSEWRKMGLEPELLREAIKRVR---------LHIKKPLIV 164 Query: 217 KIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKN---CDQTGGLSGRPLQL 273 K+AP ++E L +A D V NT + + TGGLSG ++ Sbjct: 165 KLAPQVTEIAL--MARICEEEGADAVSLINTIPAMVIDIKTRKSMIGTLTGGLSGPAIRP 222 Query: 274 KSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIV 333 + + ++ + ++P+IGVGGI S A + + AGA +Q+ + F P EI+ Sbjct: 223 VALRAVWEVAQAV--KIPVIGVGGIVSAEDALQFLIAGAKAIQVGTAN-FINPIATVEII 279 Query: 334 THI 336 I Sbjct: 280 EGI 282 >UniRef50_C8WHP0 Dihydroorotate dehydrogenase family protein n=3 Tax=Bacteria RepID=C8WHP0_EGGLE Length = 356 Score = 215 bits (548), Expect = 2e-54, Method: Composition-based stats. Identities = 71/319 (22%), Positives = 133/319 (41%), Gaps = 34/319 (10%) Query: 27 RRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDG-ECIDALGAMGFGSIEIG 85 R + G P + VN GL KNP+ +A+G G E D + G G++ Sbjct: 42 RLVEGCPRRPV--PTSVDMRVNLGGLEMKNPVTVASGTFAAGREYGDFVDVAGLGAVTTK 99 Query: 86 TVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVE--NVKKAHYDGVLGINIGKN 143 V+ GN PR+ G++N +G N GV +L E A + +N+ Sbjct: 100 GVSLNGWAGNASPRIAE--TPSGMLNSIGLQNPGVAHLKECDLPWLAERGATVIVNVSG- 156 Query: 144 KDTPVEQGKDDYLICMEKIYAYA-GYIAINISSPNTP--GLRTLQYGEALDDLLTAIKNK 200 D+Y+ +E + +NIS PN G+ ++++ +++ + Sbjct: 157 ------HSFDEYVQVIEALEDVPVDAYEVNISCPNVDAGGMTIGTCTDSVEAVVSRCRAA 210 Query: 201 QNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKN- 259 P+ VK+ P++++ + ++A + V D + NT L ++ + Sbjct: 211 TKR---------PLIVKLTPNVTD--VTEIARAAVSAGADALSLINTLLGMAIDAERRRP 259 Query: 260 --CDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQI 317 GGLSG ++ + ++ + + +P++G+GGI A E + AGA+ V + Sbjct: 260 QLARGVGGLSGPAVKPVALRMVWEVHQAV--DVPLLGMGGISCATDAVEFMLAGATAVAV 317 Query: 318 YSGFIFKGPPLIKEIVTHI 336 + F P EI+ + Sbjct: 318 GTAN-FVNPHATVEIIDGM 335 >UniRef50_Q3J7C7 Dihydroorotate oxidase B, catalytic subunit n=10 Tax=Proteobacteria RepID=Q3J7C7_NITOC Length = 331 Score = 215 bits (548), Expect = 2e-54, Method: Composition-based stats. Identities = 67/312 (21%), Positives = 121/312 (38%), Gaps = 33/312 (10%) Query: 37 LVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDGECIDA---LGAMGFGSIEIGTVTPRPQP 93 L V+ GL ++PL L +G GE G++ + T P+ Sbjct: 9 LSDTDWARLKVDFCGLELQSPLVLLSGCVGFGEEYTRVVGFSNREVGAVCLKGTTAAPRL 68 Query: 94 GNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKKAHY--DGVLGINIGKNKDTPVEQG 151 GN R++ G++N +G N GVD +V+++ A + N+ + Sbjct: 69 GNALHRIYE--TPMGMLNAIGLQNPGVDYVVDHILPALDFSETRYIANVSGS-------T 119 Query: 152 KDDYLICMEKIYAYA-GYIAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMH 208 ++Y + I INIS PN G+ ++ A + Sbjct: 120 IEEYTAVTRRFDNSPIDAIEINISCPNVKEGGVAFGNDPHMSARVVEACRKVT------- 172 Query: 209 HKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKN---CDQTGG 265 P+ K++P+ + + + A + DG NT + ++ + + GG Sbjct: 173 --RKPLITKLSPNQTS--IEENARRCIEAGTDGFAVINTLMGMAIDIEQRTPLLGNIQGG 228 Query: 266 LSGRPLQLKSTEIIRRLSLELNGR-LPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFK 324 LSG ++ + +R++ +PIIG GG+ S A E + AGA+ V + + + Sbjct: 229 LSGPAIKPIALLKVRQVYQACRAHGIPIIGQGGVASGKDALEFLIAGATTVGVGTALFY- 287 Query: 325 GPPLIKEIVTHI 336 P L +I I Sbjct: 288 DPLLCAKINAEI 299 >UniRef50_A6G037 Dihydroorotate dehydrogenase 1 n=1 Tax=Plesiocystis pacifica SIR-1 RepID=A6G037_9DELT Length = 334 Score = 214 bits (544), Expect = 5e-54, Method: Composition-based stats. Identities = 71/312 (22%), Positives = 126/312 (40%), Gaps = 24/312 (7%) Query: 32 TPFEALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDGE-CIDALGAMGFGSIEIGTVTPR 90 TP V + + L ++P+ A+G G+ + + G + ++P Sbjct: 5 TPTATPVPLESVELACDFGPLKLRSPILTASGCFAYGQQFAEFMDLRQIGGLSTKGISPL 64 Query: 91 PQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNK-DTPVE 149 P+ GN PR++ A G+IN +G N+G + + +K + L +++ N T E Sbjct: 65 PRHGNPLPRIYE--TASGMINSIGLENVGCEAFL--TEKLPFLADLDVSVWVNFFGTDFE 120 Query: 150 QGKDDYLICMEKIYAYAGYIAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAM 207 D E + +NIS PN G+ E L A Sbjct: 121 TYVDCAKTLSEGGEGRIDVLEMNISCPNIKKGGIEFGTVPEVAHRLTKACVEA------- 173 Query: 208 HHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLV---QGMKNCDQTG 264 VPI VK+ P++S+ ++ +A ++ GV NT ++ + + G Sbjct: 174 --SEVPIVVKLTPNVSD--IVAMAQAVKEAGAIGVSLINTITAMAIDVRSRRSRIATTYG 229 Query: 265 GLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFK 324 GLSG ++ + ++ +++ L G PI G+GGI + E AGA VQ+ + F Sbjct: 230 GLSGPAIKPVALRMVHQVAKALPG-FPICGMGGILTGEDVLEYFIAGAHCVQLGT-INFS 287 Query: 325 GPPLIKEIVTHI 336 P + + Sbjct: 288 EPGAALRVTREL 299 >UniRef50_D1YYV3 Dihydroorotate dehydrogenase n=1 Tax=Methanocella paludicola SANAE RepID=D1YYV3_METPS Length = 315 Score = 212 bits (541), Expect = 1e-53, Method: Composition-based stats. Identities = 67/308 (21%), Positives = 126/308 (40%), Gaps = 31/308 (10%) Query: 36 ALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKD-GECIDALGAMGFGSIEIGTVTPRPQPG 94 ++ V GLT NP LAAG+ G + + +MG G++ ++ P+ G Sbjct: 3 KSLKNDTMKLTVEAGGLTLTNPTILAAGILGTTGASLKRVASMGAGAVVTKSIGAEPKYG 62 Query: 95 NDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKKAHYDG-VLGINIGKNKDTPVEQGKD 153 + P + RL G IN MG N + ++ A G + +I + Sbjct: 63 HPNPSMIRL--ECGYINAMGLPNPSYKEFLPELETAKDSGVPVIASIFG-------ATEA 113 Query: 154 DYLICMEKIYAYAGYIAINISSPNTPG--LRTLQYGEALDDLLTAIKNKQNDLQAMHHKY 211 +++ + + A +N+S P+ G ++ + + A+K N Sbjct: 114 EFIEVAKGL-PGASAYELNVSCPHARGYGMQVGTDPALVKAIAHAVKGTVNA-------- 164 Query: 212 VPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMK---NCDQTGGLSG 268 P+ VK+ P++++ + + + D V+A NT ++ + GGLSG Sbjct: 165 -PVWVKLTPNVTD--ITSIGRAAQEGGADAVVAINTLKAIAIDIDSGYPILGNIQGGLSG 221 Query: 269 RPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPL 328 ++ + + L L +P+IG GG+ S A E I AGA+ V+I S ++ + Sbjct: 222 PAIKPVAVRCVYDLYSAL--DIPVIGAGGVSSWADAVEFIMAGAAAVEIGSA-VYDDIGV 278 Query: 329 IKEIVTHI 336 + + Sbjct: 279 FAAVSMGL 286 >UniRef50_Q1MQG1 Dihydroorotate dehydrogenase n=2 Tax=Deltaproteobacteria RepID=Q1MQG1_LAWIP Length = 314 Score = 211 bits (538), Expect = 2e-53, Method: Composition-based stats. Identities = 61/293 (20%), Positives = 114/293 (38%), Gaps = 28/293 (9%) Query: 52 LTFKNPLGLAAGLDKDG-ECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLI 110 L KNP+ A+G G E I G I + ++ +P+ GN PR+ G++ Sbjct: 20 LVLKNPVLTASGTFGYGAEFIGYGDLSQLGGIIVKGLSLKPRKGNPLPRIAE--TPCGML 77 Query: 111 NRMGFNNLGVDNLVEN--VKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGY 168 N +G N GV+ ++ + + + N+ + L + Sbjct: 78 NTIGLQNDGVELFIQKKLPRLPWKETPVIANLYATSVEEFSE-----LTAILAAEEGVAA 132 Query: 169 IAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEE 226 + +N+S PN G Q + A+ + P+ VK++P++++ Sbjct: 133 LEVNVSCPNVKSGGTFFGQDPSLAAKVTEAVCK--------NAGSKPVMVKLSPNVTDIT 184 Query: 227 LIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNC---DQTGGLSGRPLQLKSTEIIRRLS 283 + +A ++ D + NT ++ + GGLSG ++ + + + Sbjct: 185 I--IAKAVESAGADAISCINTLTGMAVDIRKRKSLLSTVIGGLSGPGIKPIALRCVWEVC 242 Query: 284 LELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 +N P+IG+GGI S E I GA VQI + + P + I + Sbjct: 243 KAVNI--PVIGIGGITSARDVLEFILVGAHAVQIGTMNFIQ-PDIAFRIAEAL 292 >UniRef50_D1JFH0 Dihydroorotate dehydrogenase electron transfer subunit/dihydroorotate dehydrogenase n=1 Tax=uncultured archaeon RepID=D1JFH0_9ARCH Length = 589 Score = 210 bits (536), Expect = 4e-53, Method: Composition-based stats. Identities = 72/315 (22%), Positives = 123/315 (39%), Gaps = 27/315 (8%) Query: 29 ITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVT 88 + TP + P G+ F NP+ AAG G+ + G G++ +V Sbjct: 273 LLSTPPARFTPEHEPELATEVCGIIFTNPIANAAGFGLSGKLLYRYAVAGAGAVVTKSVG 332 Query: 89 PRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKKAHY-DGVLGINIGKNKDTP 147 Q G P + +N MG N G+ + + A Y D L ++I Sbjct: 333 LYEQEGYPNPTFIEIA-PRSYVNAMGLPNPGIIDYGLEIGDAKYADVPLILSIFG----- 386 Query: 148 VEQGKDDYLICMEKIYAYA-GYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQA 206 + ++ + Y + N S P++ + + L ++ I+ Sbjct: 387 --KNVEECREVAKIATKYPIDMLEFNASCPHSDFVAVENQPKLLRSIIKEIRAIV----- 439 Query: 207 MHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQG-----MKNCD 261 PIAVKI+P++ + +A +L + D + A NT + R + + N Sbjct: 440 ---HPKPIAVKISPNVGDP--AGLAMTLEKAGADAITAINTVIARPVDNRLDTHILGNPT 494 Query: 262 QTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGF 321 GG SG+ L + EI+ L EL ++PII VGGI S + GAS+ Q+ S Sbjct: 495 GYGGKSGKDLTVGGKEIVFNLYKEL--KIPIIAVGGIFSAKDVIDYAKNGASMFQVGSAL 552 Query: 322 IFKGPPLIKEIVTHI 336 + + + I + Sbjct: 553 VSEDLEIFSTIKKEL 567 >UniRef50_C8W700 Dihydroorotate dehydrogenase family protein n=2 Tax=Atopobium RepID=C8W700_ATOPD Length = 308 Score = 210 bits (536), Expect = 5e-53, Method: Composition-based stats. Identities = 73/303 (24%), Positives = 125/303 (41%), Gaps = 25/303 (8%) Query: 41 KVPAKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGF-GSIEIGTVTPRPQPGNDKPR 99 VN G+ KNP+ AAG G + + G+I + V P GN PR Sbjct: 3 DQVKMAVNLGGIQMKNPINTAAGTFGYGWQFEGFYDVSLLGAITMKGVARVPWEGNPAPR 62 Query: 100 LFRLVDAEGLINRMGFNNLGVDNLVENVKKAHYD-GVLGINIGKNKDTPVEQGKDDYLIC 158 + L G++N +G N GVD+ + + D G + Q D + Sbjct: 63 MCEL--NGGMMNSVGLANPGVDDFIAHTDDYMKDLEDRGTRVIMQMAAHSVQEMIDVVER 120 Query: 159 MEKIYAYAGYIAINISSPN-TPGLRTLQY-GEALDDLLTAIKNKQNDLQAMHHKYVPIAV 216 +E++ + I +N+S PN G R L E +++ A++ +PI V Sbjct: 121 LEELNPHISAIELNVSCPNLEKGGRPLGGTPEQATEIMKAVRPLTK---------LPILV 171 Query: 217 KIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLV---QGMKNCDQTGGLSGRPLQL 273 K+AP + ++ + DG+ N+ S+ + + TGGLSG Sbjct: 172 KMAP----VNVAEIGKAFEAEGADGLTLINSIPGMSINVHTRKSRLSKPTGGLSGPLCHN 227 Query: 274 KSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIV 333 + ++ + ++ PI GVGG+++ A E I AGA+ V + S ++ P I+ Sbjct: 228 AAVRMVWECAQAVSI--PICGVGGVETGEDAAEFILAGATAVSVGSANLY-DPMCAPRIL 284 Query: 334 THI 336 + Sbjct: 285 NEL 287 >UniRef50_Q01YA2 Dihydroorotate dehydrogenase n=5 Tax=Bacteria RepID=PYRD_SOLUE Length = 304 Score = 210 bits (535), Expect = 5e-53, Method: Composition-based stats. Identities = 69/302 (22%), Positives = 122/302 (40%), Gaps = 29/302 (9%) Query: 43 PAKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAM-GFGSIEIGTVTPRPQPGNDKPRLF 101 P G+ KNP+ A+G G + L + G + ++ P GN PR+F Sbjct: 3 PQLATTICGIALKNPVLAASGTFAYGVEFEKLVDLNALGGFVVKGLSREPIEGNPPPRVF 62 Query: 102 RLVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEK 161 G+IN +G N+GV V A + +DY+ + Sbjct: 63 E--SEAGMINSVGLQNIGVRAFVAEKLPALAGLRTAV-----FANVFGYCTEDYVEVVRV 115 Query: 162 IYAYAGY--IAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVK 217 + +AG +N+S PNT G+ L +++TA K P+ VK Sbjct: 116 LNDHAGLAGYELNVSCPNTAHGGIYFSNDPVLLAEVVTAAKRVATR---------PLIVK 166 Query: 218 IAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKN---CDQTGGLSGRPLQLK 274 ++P++S + +A D + NT + ++ + GGLSG ++ Sbjct: 167 LSPNVS--AIEPLARVAEESGADALSLVNTVISLAIDARTRRPRIGAGFGGLSGPAIKPI 224 Query: 275 STEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVT 334 + + + + + R+P+IG+GGI + A E + AGAS V++ + + P I Sbjct: 225 ALRFVYQAARAV--RIPVIGLGGIATGEDAAEFLIAGASAVEVGTATFW-DPRAPLRIAE 281 Query: 335 HI 336 + Sbjct: 282 EL 283 >UniRef50_P28272 Dihydroorotate dehydrogenase n=168 Tax=cellular organisms RepID=PYRD_YEAST Length = 314 Score = 210 bits (534), Expect = 7e-53, Method: Composition-based stats. Identities = 68/303 (22%), Positives = 116/303 (38%), Gaps = 22/303 (7%) Query: 43 PAKPVNCMGLTFKNPLGLAAGL-DKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLF 101 + + T++NP A+G+ + +D L G+ + T + GN +PR Sbjct: 3 ASLTTKFLNNTYENPFMNASGVHCMTTQELDELANSKAGAFITKSATTLEREGNPEPRYI 62 Query: 102 RLVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEK 161 + G IN MG N G+D + V + I + D+ L + K Sbjct: 63 SVP--LGSINSMGLPNEGIDYYLSYVLNRQKNYPDAPAIF---FSVAGMSIDENLNLLRK 117 Query: 162 IYA--YAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIA 219 I + G +N+S PN PG + Y L K + A K P+ VK+ Sbjct: 118 IQDSEFNGITELNLSCPNVPGKPQVAYDFDLT------KETLEKVFAFFKK--PLGVKLP 169 Query: 220 PDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMK------NCDQTGGLSGRPLQL 273 P +A L + V + N+ + + K + GG+ G ++ Sbjct: 170 PYFDFAHFDIMAKILNEFPLAYVNSINSIGNGLFIDVEKESVVVKPKNGFGGIGGEYVKP 229 Query: 274 KSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIV 333 + +R L + +IG GGI S A E + GAS++QI + +G + + I Sbjct: 230 TALANVRAFYTRLRPEIKVIGTGGIKSGKDAFEHLLCGASMLQIGTELQKEGVKIFERIE 289 Query: 334 THI 336 + Sbjct: 290 KEL 292 >UniRef50_C4F860 Putative uncharacterized protein n=2 Tax=Collinsella RepID=C4F860_9ACTN Length = 307 Score = 209 bits (533), Expect = 8e-53, Method: Composition-based stats. Identities = 64/303 (21%), Positives = 115/303 (37%), Gaps = 33/303 (10%) Query: 45 KPVNCMGLTFKNPLGLAAGLDKDG-ECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRL 103 V+ G+ KNP+ A+G G + + + G+I PGN PR+ + Sbjct: 6 MAVDFGGVKMKNPINTASGTFGYGWQFSELMDVSQLGAITTKGCAAEAWPGNPAPRMAEV 65 Query: 104 VDAEGLINRMGFNNLGVDNLVENVKKAHYDGV-----LGINIGKNKDTPVEQGKDDYLIC 158 G++N +G N GV E D + + + + + ++ Sbjct: 66 P--GGMMNSVGLQNPGVAAFAEQSGPWLADLTAKGTQVICQVAGHSTEEYVRALEMFVE- 122 Query: 159 MEKIYAYAGYIAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAV 216 + +A IN+S PN G E +++ A + + P+ V Sbjct: 123 ---LCPWAAGYEINVSCPNIAAGGAACGSTPEGASEVMRACRKVTD---------KPLFV 170 Query: 217 KIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLV---QGMKNCDQTGGLSGRPLQL 273 K+AP + ++A +L DG+ N+ S+ + + TGGLSG Sbjct: 171 KMAP----VRIPEIARALEAEGADGLTVINSIPGMSIDVRTRRSRLSKPTGGLSGPLCHP 226 Query: 274 KSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIV 333 + ++ + + +PI GVGG+ + A E I AGA V + + P I+ Sbjct: 227 IAVRMVWEAANAV--DIPICGVGGVMTGEDAAEFILAGACCVSVGMANFVE-PDASVRIL 283 Query: 334 THI 336 + Sbjct: 284 HEL 286 >UniRef50_C6SRR7 Putative dihydroorotate dehydrogenase dihydroorotate oxidase n=1 Tax=Streptococcus mutans NN2025 RepID=C6SRR7_STRMN Length = 330 Score = 209 bits (533), Expect = 9e-53, Method: Composition-based stats. Identities = 69/308 (22%), Positives = 119/308 (38%), Gaps = 25/308 (8%) Query: 38 VRQKVPAKPVNCMGLTFKNPLGLAAGL-DKDGECIDALGAMGFGSIEIGTVTPRPQPGND 96 + + F N L AAG+ E + A+ GS T T + GN Sbjct: 16 FGGSMVSTHTTIGSFDFDNCLMNAAGVYCMTREELAAIDHSEAGSFVTKTGTLEERAGNP 75 Query: 97 KPRLFRLVDAEGLINRMGFNNLGVDNLVE---NVKKAHYDGVLGINIGKNKDTPVEQGKD 153 +PR G IN MG NLG++ ++ ++K +++ Sbjct: 76 QPRYA--DTKLGSINSMGLPNLGINYYLDYVTELQKQPDSKNHFLSLVGMSPEETHTILK 133 Query: 154 DYLICMEKIYAYAGYIAINISSPNTPGLRTLQYG-EALDDLLTAIKNKQNDLQAMHHKYV 212 M + Y G + +N+S PN PG + Y E D +L+ + + Sbjct: 134 -----MVEASKYQGLVELNLSCPNVPGKPQIAYDFETTDQILSEV---------FTYFTK 179 Query: 213 PIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGM----KNCDQTGGLSG 268 P+ +K+ P Q A ++ + V N+ + +++ K + GG+ G Sbjct: 180 PLGIKLPPYFDIVHFDQAAAIFNKYPLTFVNCINSIGNGLVIEDETVVIKPKNGFGGIGG 239 Query: 269 RPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPL 328 ++ + + LN + IIG GG+ + A E I GAS+VQI + +GP + Sbjct: 240 DYVKPTALANVHAFYKRLNPSIQIIGTGGVKTGRDAFEHILCGASMVQIGTALHQEGPQI 299 Query: 329 IKEIVTHI 336 K I + Sbjct: 300 FKRITKEL 307 >UniRef50_A4ECL7 Putative uncharacterized protein n=1 Tax=Collinsella aerofaciens ATCC 25986 RepID=A4ECL7_9ACTN Length = 302 Score = 208 bits (530), Expect = 2e-52, Method: Composition-based stats. Identities = 66/303 (21%), Positives = 116/303 (38%), Gaps = 33/303 (10%) Query: 45 KPVNCMGLTFKNPLGLAAGLDKDGECIDALGA-MGFGSIEIGTVTPRPQPGNDKPRLFRL 103 V+ G+ +NP+ AAG G G+I P PGN PR+ + Sbjct: 1 MAVDFGGVKMQNPINTAAGTFGYGWQFQNFFDVSQLGAITTKGCAAEPWPGNPAPRMAEI 60 Query: 104 VDAEGLINRMGFNNLGVDNLVEN----VKKAHYDGV-LGINIGKNKDTPVEQGKDDYLIC 158 G+IN +G N GV +++ DG + + + + + Y+ Sbjct: 61 P--GGMINSVGLQNPGVAAFARESGPWLEQLSKDGCQVICQVAGHSVDEFVRALEMYVE- 117 Query: 159 MEKIYAYAGYIAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAV 216 + +A IN+S PN G E ++ A + + P+ V Sbjct: 118 ---LCPWAAGYEINVSCPNIAAGGAAMGSTPEGASSVMAACRKVTD---------KPLFV 165 Query: 217 KIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLV---QGMKNCDQTGGLSGRPLQL 273 K+AP + ++A +L DG+ N+ ++ + + GGLSG Sbjct: 166 KMAP----VNVAEIAKALEAAGADGLSVINSIQGMAIDVHTRKSRVAKPKGGLSGPLCHH 221 Query: 274 KSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIV 333 + ++ ++ + +PI GVGG+ + A E I AGA+ V + F P +I Sbjct: 222 IAVRMVWEVAQAV--DIPINGVGGVMTGEDAAEFILAGATCVSVGMAN-FVDPCASLKIA 278 Query: 334 THI 336 + Sbjct: 279 HEL 281 >UniRef50_B2WMQ8 Dihydroorotate dehydrogenase, mitochondrial n=3 Tax=Leotiomyceta RepID=B2WMQ8_PYRTR Length = 455 Score = 208 bits (530), Expect = 2e-52, Method: Composition-based stats. Identities = 83/310 (26%), Positives = 132/310 (42%), Gaps = 47/310 (15%) Query: 23 FQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSI 82 + L P E + V G T NP+G +AG+DK E L +G G + Sbjct: 2 LKVLHSFGMNPRERGIADTQGDLAVEVFGHTLNNPIGTSAGIDKGAEIPTPLFELGAGVV 61 Query: 83 EIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKKAHYD--------- 133 E+G VT PQ GN KPR+FRL LINR GFN+ G + + +++ + Sbjct: 62 EVGAVTLLPQEGNPKPRVFRLPSQNALINRYGFNSEGAELVASRLRQRVREFAYRIGLGL 121 Query: 134 -----------------------GVLGINIGKNKDT---PVEQGKDDYLICMEKIYAYAG 167 ++ + + KNK T ++ DY + + YA Sbjct: 122 DEDAERRVLDGEAGVPPGSLLKGRLMAVQVAKNKTTSENDIDAVVRDYATAVGYVGKYAD 181 Query: 168 YIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEE-E 226 + +N+SSPNTPGLRTLQ E L LL+ + + + + VK++PD E + Sbjct: 182 ILVVNVSSPNTPGLRTLQNVEPLTRLLSGVVSAVKKIDRKTKPA--VMVKVSPDEDSESQ 239 Query: 227 LIQVADSLVRHNIDGVIATNTTLDRSLVQGM---------KNCDQTGGLSGRPLQLKSTE 277 + + +++ +DGVI NTT R K + GG SG + ++ Sbjct: 240 IAGICEAVWDSGVDGVIVGNTTKKRPDPLPKGYLLPESEAKLLLEQGGYSGPQMFERTLA 299 Query: 278 IIRRLSLELN 287 ++ + L+ Sbjct: 300 LVSKYRKALD 309 Score = 56.5 bits (135), Expect = 1e-06, Method: Composition-based stats. Identities = 18/48 (37%), Positives = 25/48 (52%) Query: 289 RLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 R I GGI + ARE + AGAS+ Q+Y+ I+ G I I + Sbjct: 395 RKVIFATGGITNGRQAREILDAGASVAQVYTAMIYGGAGTISRIKQEM 442 >UniRef50_C1TMB2 Dihydroorotate dehydrogenase family protein n=1 Tax=Dethiosulfovibrio peptidovorans DSM 11002 RepID=C1TMB2_9BACT Length = 304 Score = 208 bits (529), Expect = 3e-52, Method: Composition-based stats. Identities = 63/299 (21%), Positives = 124/299 (41%), Gaps = 20/299 (6%) Query: 42 VPAKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAM-GFGSIEIGTVTPRPQPGNDKPRL 100 + VN + ++P+ +A+G E + + G++ +T P+ GN R+ Sbjct: 1 MLDLSVNIGSVPLRSPVIIASGTWGYDESLWREDLLRHVGAVCSKAITESPKDGNPGHRI 60 Query: 101 FRLVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICME 160 + GL+N +G N G+D+ V+ K G+ I N E+G + + Sbjct: 61 WE--TPCGLLNSIGLQNTGIDDFVDE--KIPKLKSYGVPIIANVSMEDERGLALIVERLV 116 Query: 161 KIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAP 220 ++ I +N+S PN + +G ++ + Q P+ VK+ P Sbjct: 117 EVADCVDAIELNVSCPNV-DKGCMSWG------VSPVLTSQAVSMVQKIWKGPLWVKMTP 169 Query: 221 DLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNC---DQTGGLSGRPLQLKSTE 277 + E VA + D ++ NT L ++ + G SG + + Sbjct: 170 QAPDPE--GVARAAEDSGADALVVANTWLGMAIDVDSRKAVFDRVVAGFSGPAVFPMALR 227 Query: 278 IIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 ++ ++S ++ P+IG GG+ S I AGA+ V++ +G +F+ L + I+ + Sbjct: 228 LVWQVSSAVSI--PVIGCGGVSSGRDLLSMIMAGATAVELGTG-MFRDIRLPENILREV 283 >UniRef50_C6A1L2 Dihydroorotate dehydrogenase family protein n=1 Tax=Thermococcus sibiricus MM 739 RepID=C6A1L2_THESM Length = 309 Score = 207 bits (528), Expect = 4e-52, Method: Composition-based stats. Identities = 78/299 (26%), Positives = 132/299 (44%), Gaps = 26/299 (8%) Query: 44 AKPVNCMGLTFKNPLGLAAGLDKDG-ECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFR 102 ++ G+ F+NP+ LA+G G E + L G+I + TVT +P+ GN PRL Sbjct: 4 DLSIDVFGIKFRNPIILASGPVGFGFELMPYLDFSNIGAITLKTVTLKPREGNPPPRL-- 61 Query: 103 LVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKI 162 + G+IN +G N G++ VE + + + I IG + D++ I E++ Sbjct: 62 VDSHGGVINSIGLQNPGIEGFVEEIAPRLKE-LKTIKIG----SIAGFSMDEWEILGEEM 116 Query: 163 YAYAGYIAI--NISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAP 220 I N+S PN G R L + ++ + K PI K+AP Sbjct: 117 DKIKEIKIIEINLSCPNVKGKRRWAEDAKLTE------KVVKIVRKLTGK--PIIAKLAP 168 Query: 221 DLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKN---CDQTGGLSGRPLQLKSTE 277 D+++ ++++A + V DG+ N + +TGGL G ++ + Sbjct: 169 DVTD--IVEIAKTAVDAGADGLTIGNGAQAMRIDVETGLPILKLKTGGLGGPAVKPITLA 226 Query: 278 IIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + + L +PIIG+GGI + A E AGASL+ + + + P I+ I Sbjct: 227 KVFKTREAL--DVPIIGIGGIMNWQDAIEYAMAGASLLGLGTAVMV-DPEAPVRIIEGI 282 >UniRef50_O29513 Dihydroorotate dehydrogenase n=3 Tax=Archaeoglobaceae RepID=PYRD_ARCFU Length = 299 Score = 207 bits (526), Expect = 5e-52, Method: Composition-based stats. Identities = 63/295 (21%), Positives = 113/295 (38%), Gaps = 22/295 (7%) Query: 45 KPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLV 104 GL KNPL LA+G+ L A G++ +V + G P + + Sbjct: 4 LETEIGGLRMKNPLMLASGIMGSKVHSLNLIARDAGAVVTKSVGVEEREGYRNPTV--VN 61 Query: 105 DAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYA 164 GLIN +G + + E +K + L I++ + D + + Sbjct: 62 WKCGLINAVGLASPAAKDFAEELKDYTNEAPLLISLYGHSVEEF----SDLVDTFDSALP 117 Query: 165 YAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSE 224 Y +N+S P+ G G + L +L+ P+ K++ + Sbjct: 118 YLHGYELNLSCPHVKGA-----GLDIGMDLELSAAIVEELKGKTKN--PVFAKLS---AM 167 Query: 225 EELIQVADSLVRHNIDGVIATNTTLDRSLVQ---GMKNCDQTGGLSGRPLQLKSTEIIRR 281 + +++A L +DG+ +NT + + +GG+SG ++ + + + Sbjct: 168 HDYLKLAKVLEDAGVDGITISNTLRGMKIDIMSGKPVLSNLSGGVSGPAIKPIALKCVYD 227 Query: 282 LSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 L E +PI+G GGI S E I AGA VQI S + + + + Sbjct: 228 LYKE--IEVPIVGCGGITSFEDVLEFIMAGARAVQIGSAVYYSR-RIFYSLKESL 279 >UniRef50_Q2IVE7 Dihydroorotate oxidase B, catalytic subunit n=1 Tax=Rhodopseudomonas palustris HaA2 RepID=Q2IVE7_RHOP2 Length = 348 Score = 207 bits (526), Expect = 6e-52, Method: Composition-based stats. Identities = 84/342 (24%), Positives = 139/342 (40%), Gaps = 26/342 (7%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRI---TGTPFEALVRQKVPAKPVNCMGLTFKNP 57 +Y + LF++ P+R+H LRR A +R P G+ NP Sbjct: 3 LYRDLLAPGLFRMSPDRSHAMAHAALRRAVPWRLLAAAATLRVDDPRLVTRFAGVELPNP 62 Query: 58 LGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNN 117 +GLAAG DKD E I AL +GFG + +G++ P P+ GN PRL R E + + MG + Sbjct: 63 VGLAAGFDKDAELIAALSCLGFGFVCVGSIMPEPRVGNPFPRLVRRRGTESIADSMGVPS 122 Query: 118 LGVDNLVENVKKA-HYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSP 176 G E +++ + NIG D + ++ + + +++ P Sbjct: 123 KGRAYATERLRRLGPRAVPVIANIGGF-------SADTIAAGVIEVAPHVDLVELSLMCP 175 Query: 177 NTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLS--EEELIQVADSL 234 N L GE D++ + L + + I V++ D + + ++ + Sbjct: 176 NV-----LADGEVFDEI----GMLRGVLARLDGRAGSIVVRVPNDTTRLHDRFAELIEVC 226 Query: 235 VRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIG 294 I + + G L GR + + + R + GRL I G Sbjct: 227 ----IAAGVGGIKVGGGRRIAEPGLGTGAGTLHGREIFDTALMNVERAAGFARGRLAIKG 282 Query: 295 VGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 GGI S AGAS V +YS FI++G + ++I + Sbjct: 283 NGGISSAADVLAMRRAGASCVDLYSAFIYQGWTIARDINRAL 324 >UniRef50_B1MZ73 Dihydroorotate dehydrogenase B, catalytic subunit n=1 Tax=Leuconostoc citreum KM20 RepID=B1MZ73_LEUCK Length = 306 Score = 205 bits (522), Expect = 2e-51, Method: Composition-based stats. Identities = 64/300 (21%), Positives = 132/300 (44%), Gaps = 26/300 (8%) Query: 44 AKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRL 103 V GL KNP+ ++G G G++ TVT + GN +P + + Sbjct: 5 RLAVKLPGLDLKNPIMNSSGAVFFGLEDKGYAIEETGALVTKTVTMSARAGNPQPWI--I 62 Query: 104 VDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIY 163 G++N +G N G++ +V ++ A ++ + + + + +Y+ E++ Sbjct: 63 NTPSGILNSVGLANPGIEAVVADILPAIHEKYKTLPV---LASVAGETVGEYVALTERLT 119 Query: 164 AYAG--YIAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIA 219 A I N+S PN G+ E+ +++ A++ +PI K++ Sbjct: 120 ATKQVTAIEANLSCPNVDRGGMAFGVTAESAAEVIHAMRAAT---------TLPIYAKMS 170 Query: 220 PDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLV---QGMKNCDQTGGLSGRPLQLKST 276 P++++ + + ++ DG++ NT + SL + + TGG+SG + + Sbjct: 171 PNVTD--IKPIVKAVETAGADGIVLINTVVGMSLDLNTRQARLARGTGGMSGTSVHPIAV 228 Query: 277 EIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + + ++ P+IGVGG+ +V E + AGAS VQI + ++ +I+ + Sbjct: 229 RFVYETAQTVSI--PVIGVGGVSTVDDVLELMMAGASAVQIGTALA-GNHQVMADIIREL 285 >UniRef50_C9RJ75 Dihydroorotate oxidase n=1 Tax=Fibrobacter succinogenes subsp. succinogenes S85 RepID=C9RJ75_FIBSS Length = 391 Score = 204 bits (520), Expect = 3e-51, Method: Composition-based stats. Identities = 88/344 (25%), Positives = 138/344 (40%), Gaps = 30/344 (8%) Query: 5 FVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKP--VNCMG----LTFKNPL 58 +R+ F +PE H+ R PF V L F P+ Sbjct: 21 LIRRI-FHNNPEFRHDSLKHVARFAPIIPFMGGRPDLSKTLNRVVTFADGSNPLHFGCPI 79 Query: 59 GLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGN-DKPRLFRLVDAEGLINRMGFNN 117 LAAG +K + I MGFG I +GT T + GN +PR+ + + + N MG NN Sbjct: 80 MLAAGANKTAKRICDFANMGFGGISVGTATRHVREGNTHRPRIGFIENDRAIHNSMGLNN 139 Query: 118 LGVDNLVENV-----KKAHYDGVLGINIGKNKD-TPVEQGKDDYLICMEKIYAYAGYIAI 171 GVD + V +GI++ + T + D + Y A Y+ I Sbjct: 140 DGVDAVTRRVDTQITAAHRVQMCVGISVAETPGLTDENEKLQDIVESFSIAYRVADYVEI 199 Query: 172 NISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVA 231 N+S PNT R ++ + TAI + +N I K++PD+ E + Sbjct: 200 NLSCPNTGENRLDLDMTLVNKIFTAITDYRNK----QPVRKAIYAKLSPDMPENHTATIM 255 Query: 232 DSLVRHNIDGVIATNTTL-----------DRSLVQGMKNCDQTGGLSGRPLQLKSTEIIR 280 D LV+ ++GV+ NT + ++ + GG+SGRPL + ++ Sbjct: 256 DMLVKVGVNGVVMGNTYPTKKVTDLPVHVKYDDLTPLRADNDRGGMSGRPLYENTVRNVK 315 Query: 281 RLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFK 324 + ++ +I GGID + I G VQ YS F+ Sbjct: 316 FIREHY-PQMSVIACGGIDHGYKIYDLIKLGVDAVQCYSVVAFR 358 >UniRef50_Q1Q4L5 Similar to dihydroorotate oxidase (Dihydroorotate dehydrogenase B) catalytic subunit n=1 Tax=Candidatus Kuenenia stuttgartiensis RepID=Q1Q4L5_9BACT Length = 306 Score = 204 bits (518), Expect = 4e-51, Method: Composition-based stats. Identities = 66/299 (22%), Positives = 128/299 (42%), Gaps = 26/299 (8%) Query: 45 KPVNCMGLTFKNPLGLAAGLDKDGE-CIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRL 103 +N + NP LA+G+ + + + G G++ I +V+ + G+ P + Sbjct: 6 LSINLCSMRLSNPTVLASGILGTTKTLLKRVAESGAGAVTIKSVSKDSREGHHNPTVITY 65 Query: 104 VDAEGLINRMGFNNLGVDNL-VENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKI 162 G++N +G++N GV+ +E + +I DD++ E + Sbjct: 66 --EAGMLNAVGYSNPGVEAARIEYSNLNEIGVPVIASIIGTCT-------DDFIEVAEGL 116 Query: 163 -YAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPD 221 + I I +S P+TPG L A ++ + VPI VKI+P+ Sbjct: 117 SASGFSAIEIPLSCPHTPGFGLLSGQGT----PKATYEITYAVRRKTN--VPIFVKISPN 170 Query: 222 LSEEELIQVADSLVRHNIDGVIATNTTLDRSLV----QGMKNCDQTGGLSGRPLQLKSTE 277 + E+ +A + +G+ A N+ ++ + + GG++G L+ + Sbjct: 171 V--PEITSIAKAAEDAGANGITAVNSMGPGMVINIESKKPVLGFKVGGVTGDALRPIAVR 228 Query: 278 IIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + + + ++PIIGVGGI + A E + AGAS V I +G +G + ++ + Sbjct: 229 CVYDVYQAV--KIPIIGVGGISTGRHAIEMMMAGASAVGIGTGVYTRGINVFSKVCAEM 285 >UniRef50_C1A4J6 Dihydroorotate dehydrogenase n=1 Tax=Gemmatimonas aurantiaca T-27 RepID=C1A4J6_GEMAT Length = 327 Score = 203 bits (517), Expect = 6e-51, Method: Composition-based stats. Identities = 74/303 (24%), Positives = 124/303 (40%), Gaps = 33/303 (10%) Query: 46 PVNCMGLTFKNPLGLAAGLDKDGECI-DALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLV 104 V+ GL F+NP+ LA+G G+ + D L G I V+ P+PGN R+ Sbjct: 23 SVSVAGLAFRNPVVLASGTAGFGQELEDVLDLSAVGGISTKAVSVAPRPGNPALRVSEFA 82 Query: 105 DAEGLINRMGFNNLGVDN----LVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICME 160 G++N +G N G+++ + + H + +N+ N +D+ + Sbjct: 83 --GGMMNAIGLANPGLESVRRDYLPWLPAHHPGTRVFVNVVGN-------SIEDFATVVR 133 Query: 161 KIY--AYAGYIAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAV 216 + +N+S PN GL +AL L++A + PI V Sbjct: 134 GLDDVPGVDAFELNVSCPNVKAGGLEFGADPQALHALVSAARGATKR---------PIFV 184 Query: 217 KIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCD---QTGGLSGRPLQL 273 K++P L + A V G+ NT + + +GG+SG L Sbjct: 185 KLSPTLG-AAIADTARVAVDAGATGLTLVNTMPGTVIDTDRRRPKLSFGSGGVSGPALLP 243 Query: 274 KSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIV 333 R+S L +P+IG+GGI + A + + AGASLV + + + P + IV Sbjct: 244 VGLLATWRVSRAL-PTVPLIGLGGISTGDDALQYLMAGASLVGVGTA-ALRDPRAPERIV 301 Query: 334 THI 336 + Sbjct: 302 RQL 304 >UniRef50_B1GYY3 Dihydroorotate dehydrogenase n=1 Tax=uncultured Termite group 1 bacterium phylotype Rs-D17 RepID=PYRD_UNCTG Length = 306 Score = 203 bits (516), Expect = 9e-51, Method: Composition-based stats. Identities = 67/280 (23%), Positives = 116/280 (41%), Gaps = 30/280 (10%) Query: 43 PAKPVNCMGLTFKNPLGLAAGLDKDG-ECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLF 101 P VN G+ KNP+ A+G G E D + G + TVT P+ GN +PR+ Sbjct: 3 PDLSVNFAGIKLKNPVLTASGTFGYGYELADLIPLKRLGGVVTKTVTLEPRAGNLQPRIA 62 Query: 102 RLVDAEGLINRMGFNNLGVDNLVENV--KKAHYDGVLGINIGKNKDTPVEQGKDDYLICM 159 + G++N +G N+GV +E K + +++ +Y+ + Sbjct: 63 EVAS--GILNSIGLQNIGVRAFIEEPLEKLNKIGVPVIVSVAG-------VAVGEYVEIV 113 Query: 160 EKIY--AYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVK 217 + + I +N+S PN + D++ +K VP+ K Sbjct: 114 KILSSQNGVSAIELNLSCPNLKKKIVCHDLPLMRDVIRGVKKV---------SRVPVIAK 164 Query: 218 IAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGM---KNCDQTGGLSGRPLQLK 274 ++P +++ + ++A + DGV TNT ++ K GG+SG ++ Sbjct: 165 LSPLVTD--ISELALTAQNAGADGVTLTNTYPAMAVDIRTFKPKLSTVKGGMSGACIKPM 222 Query: 275 STEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASL 314 S + + ++PIIG GGI A E I AGA+ Sbjct: 223 SVRCVYDAYQ--DIKIPIIGCGGIMMGEDAVEFILAGATA 260 >UniRef50_B8D3W9 Dihydroorotate dehydrogenase, PyrD n=1 Tax=Desulfurococcus kamchatkensis 1221n RepID=B8D3W9_DESK1 Length = 302 Score = 201 bits (512), Expect = 2e-50, Method: Composition-based stats. Identities = 68/298 (22%), Positives = 124/298 (41%), Gaps = 27/298 (9%) Query: 45 KPVNCMGLTFKNPLGLAAGLDKDG-ECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRL 103 + GL K+P+ A+G+ E ++ L GF ++ T+T P+ G P + L Sbjct: 5 LETSIAGLRLKHPVMNASGILGSEPEHLEILAKQGFSALVSKTITLNPREGYPPPIIVEL 64 Query: 104 VDAEGLINRMGFNNLGVDNLVENVKKAHY-DGVLGINIGKNKDTPVEQGKDDYLICMEKI 162 GL+N +G N G + +KA L ++IG + ++++ E Sbjct: 65 R-NNGLLNAVGLANPGARVIPVLARKARELSKPLILSIGGS-------SVEEFVKLAELA 116 Query: 163 YA-YAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPD 221 + +N+S P+ G YG L + D A+ +P+ K+ Sbjct: 117 SEAGVDAVELNLSCPHAEG-----YGLELGSDPMLVYRIVKD--AVSVASLPVIAKLGL- 168 Query: 222 LSEEELIQVADSLVRHNIDGVIATNTTLDRSLV---QGMKNCDQTGGLSGRPLQLKSTEI 278 + +I+ A + + + NT S+ ++ GGLSG P+ + + Sbjct: 169 --TDRVIESAGKALEAGVKALTLINTVKAMSIDVYTLKPVLSNKYGGLSGPPIHPIAVRV 226 Query: 279 IRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + + E IIGVGG+ S + E I AGA VQ+ + I+ ++ EI++ + Sbjct: 227 VYDVYREYRAE--IIGVGGVSSWMDVAELILAGARAVQVGTALIW-NENIVDEILSGL 281 >UniRef50_C2D6B3 Dihydroorotate oxidase n=1 Tax=Atopobium vaginae DSM 15829 RepID=C2D6B3_9ACTN Length = 309 Score = 200 bits (508), Expect = 7e-50, Method: Composition-based stats. Identities = 67/308 (21%), Positives = 118/308 (38%), Gaps = 33/308 (10%) Query: 40 QKVPAKPVNCMGLTFKNPLGLAAGLDKDGECIDALGA-MGFGSIEIGTVTPRPQPGNDKP 98 + + VN G+ KNP+ AAG G+ + G+I + +P GN P Sbjct: 3 ETPVSMEVNLGGIHMKNPVNTAAGTFAFGQQFEKFYDVSQLGAITTKGASIKPWAGNPAP 62 Query: 99 RLFRLVDAEGLINRMGFNNLGVDNLV----ENVKKAHYDGVLGINIGKNKDTPVEQGKDD 154 R+ + G+IN +G N GV+ L+ + I D+ Sbjct: 63 RMCEVTS--GIINSVGLQNPGVNGLINTAGAYLTGLQQKNCQVI------CQVAGHSIDE 114 Query: 155 YLICMEKIYAYAGY---IAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKY 211 Y+ +E A + INIS PN G A+ L+ + + Sbjct: 115 YVAALEVFEEKASFAAGFEINISCPNIA-----CGGAAMGSTPQGAAEIMRRLRPLTKR- 168 Query: 212 VPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQ---GMKNCDQTGGLSG 268 P+ VK+ P + ++A +L D + N+ ++ K TGG SG Sbjct: 169 -PLLVKMGP----VNIPEIARALESEGADALSLINSIPGMAIDTTTYKSKLSRPTGGFSG 223 Query: 269 RPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPL 328 + + ++ + ++P+ G+GGI + + A E I AGA+ V + ++ P Sbjct: 224 PAIHPIAVRMVWEAHKAV--KIPLCGIGGITTGLEAAEFILAGATAVSVGLANLY-DPMS 280 Query: 329 IKEIVTHI 336 I+ + Sbjct: 281 APRILHEL 288 >UniRef50_C1EGR6 Predicted protein n=8 Tax=Viridiplantae RepID=C1EGR6_9CHLO Length = 434 Score = 200 bits (508), Expect = 7e-50, Method: Composition-based stats. Identities = 62/335 (18%), Positives = 127/335 (37%), Gaps = 26/335 (7%) Query: 20 EFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAAGLDK-DGECIDALGAMG 78 + L + V P V GL F NP + +G + + G Sbjct: 39 RVVARGLEGRPWVELKDGVPTSGPDLSVTVNGLKFPNPFVIGSGPPGTNYTVMKKAFDEG 98 Query: 79 FGSIEIGTVTPRPQ-PGNDKPRLFRLVDAEG-----LINRMGFNNLGVDNLVENVKKAHY 132 +G + TV+ N PR ++ +G N ++ + ++ K+ Sbjct: 99 WGGVIAKTVSLNADLVKNVTPRYAKMKSEDGAEVLGWQNIELISDRSFEVMLAEFKQLKE 158 Query: 133 DGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDD 192 + I I D ++ + + E++ IN S P+ G+ + G A+ Sbjct: 159 EYPDRILIASIMDEYKKENWVEVVRRCEEVG--VDAFEINFSCPH--GMPERKMGAAMGQ 214 Query: 193 LLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRS 252 T + ++ + VP+ K+ P++++ + + A+ + +DG+ A NT + Sbjct: 215 DCTVLDEVCGWVKEV--ATVPVWAKMTPNITD--ITEPANVCLEKGMDGIAAINTIMSIM 270 Query: 253 LVQGMKNCDQT--------GGLSGRPLQLKSTE---IIRRLSLELNGRLPIIGVGGIDSV 301 V + GG S + ++ + I ++ + + G+GGID+ Sbjct: 271 GVNLDTLAPEPCVEGHSTPGGYSYKAVRPIALAKCMAIAQMIKKEFPDRTLSGIGGIDTG 330 Query: 302 IAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 A E I G+ VQ+ +G + G PL++ + + Sbjct: 331 GHAAEFILLGSDTVQVCTGVMIHGYPLVQNLCAEL 365 >UniRef50_Q3B2I1 Dihydroorotate oxidase B, catalytic subunit n=12 Tax=Chlorobiaceae RepID=Q3B2I1_PELLD Length = 331 Score = 199 bits (507), Expect = 9e-50, Method: Composition-based stats. Identities = 69/292 (23%), Positives = 130/292 (44%), Gaps = 25/292 (8%) Query: 51 GLTFKNPLGLAAGLDKDGECIDALGAM-GFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGL 109 GL+ K+P+ LA+G GE + L + G I ++ + GN R+ G+ Sbjct: 37 GLSLKSPVMLASGTVSYGEELCRLTDLSKIGGIVTKAISLEARAGNPPQRIAE--TPSGM 94 Query: 110 INRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIY--AYAG 167 IN +G N+G+D + K + LG I N + D+Y + ++ Sbjct: 95 INAIGLANVGIDRFISE--KVPFLQTLGTAIVVN---IAGRSIDEYAEVVSRLDAVPGLD 149 Query: 168 YIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEEL 227 IN+S PN G + A + +L+++ ++ + +K+ P+++ + Sbjct: 150 GYEINLSCPNVKGECMIMGVS-----PDATREIVTELRSITGRH--LMIKLTPNVTS--I 200 Query: 228 IQVADSLVRHNIDGVIATNTTLDRSLVQGMKN---CDQTGGLSGRPLQLKSTEIIRRLSL 284 +A + + D V NT + ++ + + TGGLSG ++ + + ++ Sbjct: 201 SAIAIAAEKAGADSVSLINTLVGMAIDWKKRRPLLKNVTGGLSGPAIKPVALAKVWEVNN 260 Query: 285 ELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 ++ PI+G+GGI S A E + AGA VQI + F P + ++I T + Sbjct: 261 AVSI--PIVGMGGIASFDDAMEFLVAGAGAVQIGT-MNFVQPDIGEKIATAM 309 >UniRef50_A9D5Y9 Dihydroorotate dehydrogenase n=1 Tax=Shewanella benthica KT99 RepID=A9D5Y9_9GAMM Length = 334 Score = 199 bits (506), Expect = 1e-49, Method: Composition-based stats. Identities = 68/316 (21%), Positives = 114/316 (36%), Gaps = 29/316 (9%) Query: 34 FEALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDGE-CIDALGAMGFGSIEIGTVTPRPQ 92 EA+ R + + + A+G E ++ LGA +I + T P+ Sbjct: 13 IEAVNRCVNKRISTRIAQVPLASFIFNASGPRCTEEDELNLLGASASAAIMTKSCTLEPR 72 Query: 93 PGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKKAHY------DGVLGINIGKNKDT 146 GN +PR L G I MG NLG +E + + + + +++ Sbjct: 73 QGNAEPRYQALP--LGSIQSMGLPNLGYQAYLEMLPRLKQAISPQTNKPIVVSVSGFSLA 130 Query: 147 PVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQA 206 + A I +N S PN G Q G + A++ Sbjct: 131 DNLTMVKAFQASC------ADLIEVNFSCPNIEGKP--QVGYDFEQTERALEQL------ 176 Query: 207 MHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGM------KNC 260 PI +K+ P I +A+ + + + + N+ + ++ K Sbjct: 177 CQLGSKPIGLKLPPYFDFSHFITMANIIKKFPVRFITCINSVGNTLVIDPETESAIIKPK 236 Query: 261 DQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSG 320 GGL G ++ +R S L + IIGVGGI + A E + AGAS VQ+ + Sbjct: 237 GGFGGLCGDYIKPIGLANVRAFSQLLPSSIDIIGVGGIKTGTDAFEYLLAGASAVQVATC 296 Query: 321 FIFKGPPLIKEIVTHI 336 F +G I + Sbjct: 297 FEKEGIECFDRIAKEL 312 >UniRef50_B1I4M6 Dihydroorotate dehydrogenase n=73 Tax=Bacteria RepID=PYRD_DESAP Length = 307 Score = 199 bits (506), Expect = 1e-49, Method: Composition-based stats. Identities = 68/287 (23%), Positives = 126/287 (43%), Gaps = 32/287 (11%) Query: 46 PVNCMGLTFKNPLGLAAGLDKDGE-CIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLV 104 V GLT KNP+ A+G GE L G G++ + TVT +P+ GN PR+ Sbjct: 6 AVAIAGLTLKNPVLTASGTVGFGEEYAPYLDLAGLGALVVKTVTLKPRAGNPPPRITE-- 63 Query: 105 DAEGLINRMGFNNLGVDNLVENV--KKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKI 162 G+IN +G N GV+ LV ++ + A +D + ++I + D+Y ++ Sbjct: 64 TPAGVINAVGLQNPGVEALVRDILPRLARFDVPVIVSIAG-------ETVDEYARLAGRL 116 Query: 163 Y--AYAGYIAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKI 218 + +NIS PN G+ ++ ++ + +P+ K+ Sbjct: 117 DGVPGIAALEVNISCPNVKAGGIAFGTEPAMTAAVVRQVRE---------NTRLPVIAKL 167 Query: 219 APDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKN---CDQTGGLSGRPLQLKS 275 +P++++ + +A + D + NT + + + GGLSG ++ + Sbjct: 168 SPNVTD--IRTIALAAAGAGADALSLINTLSAMVIDVERRRPLLGNVFGGLSGPAVRPVA 225 Query: 276 TEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFI 322 + ++ + LP+IG+GGI + A E I AGA V + + + Sbjct: 226 VRAVWQVYQAV--ELPLIGMGGIMTARDALEFILAGARAVAVGTANL 270 >UniRef50_Q0B324 Dihydroorotate oxidase B, catalytic subunit n=8 Tax=Proteobacteria RepID=Q0B324_BURCM Length = 325 Score = 199 bits (505), Expect = 1e-49, Method: Composition-based stats. Identities = 72/300 (24%), Positives = 131/300 (43%), Gaps = 26/300 (8%) Query: 42 VPAKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLF 101 + V L +NP+ A+G E DAL G G++ I +V+P +PGN PR+ Sbjct: 1 MADLSVRVGELRLRNPVMPASGCFA-IEYRDALDLTGLGALVIKSVSPVSRPGNPTPRVA 59 Query: 102 RLVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEK 161 +G++N +G + G+D+ +E+V A+ + + DT + + Sbjct: 60 --DAGDGMLNSIGIPSRGIDDYLEHVLPAYTGHGTPVVASVSADTADAFARACEALS--- 114 Query: 162 IYAYAGYIAINISSPN--TPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIA 219 I NIS PN G+ ++ AI+ + P+ VK+ Sbjct: 115 -RPDVAAIEANISCPNLEADGMAFGMDAGMTRQVVDAIRTRTGH---------PLWVKLT 164 Query: 220 PDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKN---CDQTGGLSGRPLQLKST 276 P+ + ++A + D ++ NT L S+ + + GGLSG ++ + Sbjct: 165 PN--AGNIAKIAQAAQDAGADAIVMGNTVLGMSIDVRTRRPSLGNVMGGLSGPSIKPIAL 222 Query: 277 EIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 ++ + ++ P+IG GGI S A E + AGAS VQ+ + F+ P +++ I+ + Sbjct: 223 RLVHQCYRAVSI--PVIGCGGIRSAADAIEFLLAGASAVQVGTAS-FRDPGVMRTIIDGL 279 >UniRef50_Q00YC9 Dihydroorotate dehydrogenase (ISS) (Fragment) n=1 Tax=Ostreococcus tauri RepID=Q00YC9_OSTTA Length = 369 Score = 197 bits (502), Expect = 4e-49, Method: Composition-based stats. Identities = 88/212 (41%), Positives = 127/212 (59%), Gaps = 3/212 (1%) Query: 126 NVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQ 185 ++ GVLG+N+GKNK TP DDY++ ++ I Y YI +N+SSPNTPGLR LQ Sbjct: 8 RAREDVPAGVLGVNLGKNKTTPEANAADDYVLGVDNIGEYGDYIVVNVSSPNTPGLRNLQ 67 Query: 186 YGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIAT 245 + L LL + + ++ + P+ VKIAPDL++ E+ VA + +DGVI + Sbjct: 68 GRKHLSGLLRKVLSARD--RNPATAKKPVLVKIAPDLTDAEIKDVASVVKSEKVDGVIVS 125 Query: 246 NTTLDRSLVQG-MKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAA 304 NTT+ R K+ D+ GGLSG+PL ST ++ L G++P++G GG+ S A Sbjct: 126 NTTVARPEEIKAHKHGDEAGGLSGKPLMESSTRVLHELYRLTGGKIPLVGCGGVASGEDA 185 Query: 305 REKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 KI AGA+LVQ+Y+ F F GPPLI +I + Sbjct: 186 YAKIRAGATLVQLYTAFAFGGPPLILKIKREL 217 >UniRef50_Q9LVI9 Senescencs-related protein; dihydroorotate dehydrogenase-like protein n=14 Tax=cellular organisms RepID=Q9LVI9_ARATH Length = 426 Score = 197 bits (500), Expect = 6e-49, Method: Composition-based stats. Identities = 54/317 (17%), Positives = 123/317 (38%), Gaps = 31/317 (9%) Query: 43 PAKPVNCMGLTFKNPLGLAAGLDK-DGECIDALGAMGFGSIEIGTVTPRP-QPGNDKPRL 100 P V GL NP + +G + + G+G++ TV+ + N PR Sbjct: 50 PDLSVTVNGLKMPNPFVIGSGPPGTNYTVMKRAFDEGWGAVIAKTVSLDASKVINVTPRY 109 Query: 101 FRLVDAE---------GLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQG 151 RL G N ++ ++ +++ ++ + I I + + Sbjct: 110 ARLRTGSNGSAKTDVIGWQNIELISDRPLETMLKEFERLKKEYPDRILIASVMEEYNKTA 169 Query: 152 KDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKY 211 ++ + +E+ + IN S P+ G+ + G A+ + + A Sbjct: 170 WEELIDRVEQTG--VDALEINFSCPH--GMPERRMGAAVGQDCALLDEVCGWINAK--AT 223 Query: 212 VPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQT-------- 263 VP+ K+ P++++ + + A ++ +G+ A NT + + + Sbjct: 224 VPVWAKMTPNITD--ITEPARVSLKSGCEGIAAINTIMSVMGIDMKTLRPEPCVEGYSTP 281 Query: 264 GGLSGRPLQLKSTEII----RRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYS 319 GG S + ++ + + + + E + + G+GG+++ A E I G++ VQ+ + Sbjct: 282 GGYSYKAVRPIALAKVMNIAKMMKSEFSEDRSLSGIGGVETGYDAAEFILLGSNTVQVCT 341 Query: 320 GFIFKGPPLIKEIVTHI 336 G + G +K + + Sbjct: 342 GVMMHGYGHVKTLCAEL 358 >UniRef50_A0NIQ6 Dihydroorotate dehydrogenase A n=7 Tax=Lactobacillales RepID=A0NIQ6_OENOE Length = 329 Score = 197 bits (500), Expect = 6e-49, Method: Composition-based stats. Identities = 65/299 (21%), Positives = 117/299 (39%), Gaps = 21/299 (7%) Query: 46 PVNCMGLTFKNPLGLAAGLDK-DGECIDALGAMG-FGSIEIGTVTPRPQPGNDKPRLFRL 103 F + AAG+ E ++ + G++ + T + + GN +PR F Sbjct: 21 TTKIANQVFHHLFINAAGVYCQTVEELEQIQNAPCAGAVITKSATAKERSGNSEPRYFEN 80 Query: 104 VDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIY 163 IN MG NLG+D + V K +I + + + Sbjct: 81 SVEHNTINSMGLPNLGIDYYLNYVLKHSLKLPTLFSIVGLSQSEIIDNLKKL-----QAS 135 Query: 164 AYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLS 223 ++G +N+S PN PG + Y TA + +++ A + K P+ VK+ P Sbjct: 136 GFSGLTELNLSCPNVPGKPQIAY------DFTATREILDNVFAFYSK--PLGVKLPPYFD 187 Query: 224 EEELIQVADSLVRHNIDGVIATNTTLDRSLVQGM------KNCDQTGGLSGRPLQLKSTE 277 Q+A L + + V A N+ + ++ K D GGL G+ ++ + Sbjct: 188 TAHFDQIASILNDYPLTYVNAINSVGNGLVIDPETDTPVIKPKDGFGGLGGKQIKATALA 247 Query: 278 IIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 +R L L ++ II GG+ + + + GA L+ I S +GP + + + Sbjct: 248 NVRALRQRLYPQIKIIATGGVTNGRDVYDHLLCGADLISIGSQLEIEGPTVFARLEKEL 306 >UniRef50_B7RZ94 Dihydroorotate dehydrogenase family protein n=3 Tax=Bacteria RepID=B7RZ94_9GAMM Length = 552 Score = 196 bits (498), Expect = 1e-48, Method: Composition-based stats. Identities = 54/297 (18%), Positives = 110/297 (37%), Gaps = 26/297 (8%) Query: 32 TPFEALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDGE-CIDALGAM--GFGSIEIGTVT 88 P +L + G T P + +G+ I + G + ++ Sbjct: 1 MPHPSLHPTESSNLSTELFGKTLSGPFTIPSGIVTTAVPIIQYIFDHMPEVGVVTTKSIG 60 Query: 89 PRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPV 148 P P+ G +P L + +N +G N G E + + + + Sbjct: 61 PEPRDGYREPVLSQYA-PGCFVNAVGLTNPGPQRSAELMAQLRVPEDRFL-----LTSIF 114 Query: 149 EQGKDDYLICMEKIYAYAGYIAINISSPNTPG--LRTLQYGEALDDLLTAIKNKQNDLQA 206 D+++ + + + + +N+S P+ G + Q + + +++ A+K + Sbjct: 115 GGSIDEFVEVAKILAPVSDGLELNLSCPHAKGYGMAMGQDPDMVREIVAAVKAVVD---- 170 Query: 207 MHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLD--RSLVQGMKNCDQTG 264 +P+ K+ P+ + + +A + DG A NT S + G Sbjct: 171 -----IPVIPKLTPNTPD--ITVIARAAEAGGADGFCAINTVGPGYTSAHGHPVLSNGAG 223 Query: 265 GLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGF 321 G+SG+ + + ++ ++ LPIIG GG+ S R AGA +V + S Sbjct: 224 GMSGKGILPIGLKCVKEVAEVS--DLPIIGCGGVSSADDVRAFFDAGAEIVGVGSAL 278 >UniRef50_A1RZC9 Dihydroorotate oxidase B, catalytic subunit n=2 Tax=Archaea RepID=A1RZC9_THEPD Length = 299 Score = 195 bits (497), Expect = 1e-48, Method: Composition-based stats. Identities = 71/301 (23%), Positives = 127/301 (42%), Gaps = 29/301 (9%) Query: 42 VPAKPVNCMGLTFKNPLGLAAGLDK-DGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRL 100 + V GL +NP+ +A+G+ + G G++ TVT P+ G P + Sbjct: 1 MVELSVEVAGLRLRNPVVVASGVLGVSVGLMKRAEDAGAGAVTSKTVTLNPREGYPNPVV 60 Query: 101 FRLVDAEGLINRMGFNNLGVDNLVENVKKAHY--DGVLGINIGKNKDTPVEQGKDDYLIC 158 + L GL+N MG N G + + +++A + +IG + D + Sbjct: 61 YEL--DYGLVNSMGLPNPGAEEMGRILREARRVLGIPVIASIGASTP--------DEALR 110 Query: 159 MEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKI 218 + + + +N S P+ GL G L A+ + L++ ++ + +K+ Sbjct: 111 IAEALEGFDALELNASCPHVKGL-----GADLMSDPDAVYGIVSALKSSGYR---VFLKL 162 Query: 219 APDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLV---QGMKNCDQTGGLSGRPLQLKS 275 +P + + VA +DG A NT + + GGLSGR + + Sbjct: 163 SP---HGDYLAVARKAYSAGVDGFTAINTAKAMVIDVYARKPVLGGVVGGLSGRAIHPIA 219 Query: 276 TEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTH 335 ++ L E +P+IG GG++ + A E I AGAS V + + +G +I EI+ Sbjct: 220 VRVVYELHREF-PEVPVIGTGGVEGWVEAVELILAGASAVGVGTAL-KRGFEVIGEILGG 277 Query: 336 I 336 I Sbjct: 278 I 278 >UniRef50_A5VL42 Dihydroorotate oxidase B, catalytic subunit n=14 Tax=Bacteria RepID=A5VL42_LACRD Length = 432 Score = 195 bits (496), Expect = 2e-48, Method: Composition-based stats. Identities = 60/314 (19%), Positives = 126/314 (40%), Gaps = 35/314 (11%) Query: 43 PAKPVNCMGLTFKNPLGLAAGLDKDG-ECIDALGAMGFGSIEIGTVTP-RPQPGNDKPRL 100 V+ +G+ F+NP L++ + E G+G I T++P + PR Sbjct: 4 KDLSVDFLGVHFENPFCLSSSPVGNCYEMCKNAYDAGWGGIVYKTLSPTHFKIDEVSPRF 63 Query: 101 FRLVDAE----GLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYL 156 L + N + ++ + ++++ + + I + + + +D+ Sbjct: 64 DELAKEDMHFVAFKNMEQLSEHPLEQDLADMRRLKEEYPNKVLIA----SIMGETLEDWT 119 Query: 157 ICMEKIYA-YAGYIAINISSP----NTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKY 211 + + A I +N S P +T G E A+K Sbjct: 120 NLAKLVTETGADMIELNFSCPQMTSHTMGSDVGTNPELCKKNCEAVKR---------GTS 170 Query: 212 VPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTT---LDRSLVQGMKNCDQTG---- 264 +P+ K+ P+++ ++ V + + DG A NT +D L + + + G Sbjct: 171 LPVLAKMTPNITT--MVPVVKACLEGGADGFSAINTVKSIVDVDLKKKVGLPNIDGKSSV 228 Query: 265 -GLSGRPLQLKSTEIIRRLSLELN-GRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFI 322 GLSG+ ++ + +++L +LPI G+GGI++ A E I GA+ +Q+ + + Sbjct: 229 SGLSGKAVKPIALRFLQQLRSAAGLEQLPISGIGGIETWEDAAEFILLGATTLQVTTAIM 288 Query: 323 FKGPPLIKEIVTHI 336 G +I ++ + Sbjct: 289 EYGYRIIDDLTNGL 302 >UniRef50_Q12882 Dihydropyrimidine dehydrogenase [NADP+] n=94 Tax=Eukaryota RepID=DPYD_HUMAN Length = 1025 Score = 195 bits (495), Expect = 2e-48, Method: Composition-based stats. Identities = 62/320 (19%), Positives = 120/320 (37%), Gaps = 38/320 (11%) Query: 41 KVPAKPVNCMGLTFKNPLGLAAGLDKDGE-CIDALGAMGFGSIEIGTVTPRPQ-PGNDKP 98 + V GL F NP GLA+ I G+G T + N P Sbjct: 529 DLVDISVEMAGLKFINPFGLASATPATSTSMIRRAFEAGWGFALTKTFSLDKDIVTNVSP 588 Query: 99 RLFRL--------VDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQ 150 R+ R +N + ++V + D I I + + Sbjct: 589 RIIRGTTSGPMYGPGQSSFLNIELISEKTAAYWCQSVTELKADFPDNIVIASIMCSYNKN 648 Query: 151 GKDDYLICMEKIYAYAGYIAINISSPNTPGLRTL-----QYGEALDDLLTAIKNKQNDLQ 205 + E + A + +N+S P+ G R + Q E + ++ ++ Sbjct: 649 DWTELAKKSE--DSGADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVQ--- 703 Query: 206 AMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQ---------G 256 +P K+ P++++ ++ +A + +GV ATNT ++ G Sbjct: 704 ------IPFFAKLTPNVTD--IVSIARAAKEGGANGVTATNTVSGLMGLKSDGTPWPAVG 755 Query: 257 MKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQ 316 + GG+SG ++ + + ++ L G PI+ GGIDS + + + +GAS++Q Sbjct: 756 IAKRTTYGGVSGTAIRPIALRAVTSIARALPG-FPILATGGIDSAESGLQFLHSGASVLQ 814 Query: 317 IYSGFIFKGPPLIKEIVTHI 336 + S + +I++ T + Sbjct: 815 VCSAIQNQDFTVIEDYCTGL 834 >UniRef50_D2RBF2 Dihydroorotate dehydrogenase 1B n=21 Tax=Bifidobacteriaceae RepID=D2RBF2_GARVA Length = 333 Score = 194 bits (494), Expect = 3e-48, Method: Composition-based stats. Identities = 73/304 (24%), Positives = 123/304 (40%), Gaps = 30/304 (9%) Query: 41 KVPAKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRL 100 V P G+ +KN +G A+G + C G+I V+P P GN PR Sbjct: 31 HVWKHPTQVAGVKWKNMVGTASGTFQLAACRRFYDVSQLGAICTKGVSPVPWEGNPSPRT 90 Query: 101 FRLVDAEGLINRMGFNNLGVDNLV-ENVKKAHYDGVLGI-NIGKNKDTPVEQGKDDYLIC 158 G++N +G N GVD+ + + + K G L I N+ + D DDY Sbjct: 91 AE--SPSGMVNAVGLQNPGVDHYLVDELPKLKKMGALVITNVAGHSD-------DDYAQV 141 Query: 159 MEKIYA-YAGYIAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIA 215 +EK+ A + IN+S PN G+ AL L+ ++ + P+ Sbjct: 142 VEKLADSAADMLEINVSCPNVTHGGMSVGTDPVALHRLIKRLRAMTD---------KPMI 192 Query: 216 VKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKN---CDQTGGLSGRPLQ 272 VK+ P++++ ++ + + V D + NT + + ++TGG+SG + Sbjct: 193 VKMTPNVTD--IVSICKAAVDAGADALSMINTLVGLRIDIRTGEPIIANRTGGVSGPAIF 250 Query: 273 LKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 + R+ + I GIDS A E + AGA+ V++ P I Sbjct: 251 PIGLGFVWRVRQAMPDIPIIGIG-GIDSGEKALEYLYAGANAVEVG-AAALVDPTAPIRI 308 Query: 333 VTHI 336 + Sbjct: 309 AREL 312 >UniRef50_A9BIU8 Dihydroorotate dehydrogenase family protein n=10 Tax=Bacteria RepID=A9BIU8_PETMO Length = 363 Score = 194 bits (493), Expect = 4e-48, Method: Composition-based stats. Identities = 69/302 (22%), Positives = 121/302 (40%), Gaps = 37/302 (12%) Query: 42 VPAKPVNCMGLTFKNPLGLAAGLD-KDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRL 100 + V+ +G+ K P+ AAG KDGE G G+I TV+ R KP + Sbjct: 1 MADISVDLLGMLLKTPVMPAAGPPIKDGESAHKAKEGGAGAIVTKTVSARAAK-VPKPNM 59 Query: 101 FRLVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICME 160 ++ G IN ++ L ++ +E + L + IG +D + Sbjct: 60 AQV--KGGFINTELWSELSLEQWIEKEYPQVVETGLPVIIGV------GYTSEDIKEVIP 111 Query: 161 KIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAP 220 K+ +A ++ + + + A K + +P+ VK++P Sbjct: 112 KVERFADAFELSTH-------YLGNDPTPMINSIRAAKETTD---------LPVMVKLSP 155 Query: 221 DLSEEELIQVADSLVRHNIDGVIATNT---TLDRSLVQGMKNC---DQTGGLSGRPLQLK 274 + + + A DG++ N+ TLD L G + G LSG+ + Sbjct: 156 QVD---IPKFAKEAENAGADGLVLINSFGPTLDIDLESGKPLLGSENGFGWLSGQAIFPL 212 Query: 275 STEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVT 334 + + +N P++GVGGI++ A + I AGA VQ+ + I GP + K+I Sbjct: 213 ALRSVFEAVRSVNI--PVVGVGGINTGKEAIKMIMAGAQAVQVCTAAILNGPQIYKKITN 270 Query: 335 HI 336 I Sbjct: 271 EI 272 >UniRef50_C5R8W8 Dihydroorotate dehydrogenase B, catalytic subunit n=1 Tax=Weissella paramesenteroides ATCC 33313 RepID=C5R8W8_WEIPA Length = 323 Score = 193 bits (490), Expect = 9e-48, Method: Composition-based stats. Identities = 66/290 (22%), Positives = 120/290 (41%), Gaps = 34/290 (11%) Query: 41 KVPAKPVNCMGLTFKNPLGLAAGLDKDG-ECIDALGAMGFGSIEIGTVTPRPQPGNDKPR 99 V+ GL KNP ++G G + +D G++ + T T P+ GN +P Sbjct: 2 NDERYAVSLPGLKLKNPFMPSSGAFYYGLDHMDDFDLNKLGALVLKTTTLAPRTGNPQPW 61 Query: 100 LFRLVDAEGLINRMGFNNLGVDN----LVENVKKAHYDGVLGINIGKNKDTPVEQGKDDY 155 + + G++N +G N G+ + + D ++I D++ Sbjct: 62 I--VNTKAGILNSVGLANPGIAAVKADFLPELAAKLPDLPKMLSISG-------ATVDEF 112 Query: 156 LICMEKIY--AYAGYIAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKY 211 + + I I +N+S PN G + +++A++ Sbjct: 113 VQLAKIIDKLPAINAIELNLSCPNVDEGGCAFGVTESGIHSVVSAVRAVTTKA------- 165 Query: 212 VPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCD---QTGGLSG 268 I K++P++++ + +A + DG+ NT + SL ++ GGLSG Sbjct: 166 --IYAKLSPNVTD--IKPLAVTAENAGADGLTMVNTLVGMSLDLQSRSARLYRGKGGLSG 221 Query: 269 RPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIY 318 L + E+I + + +PIIGVGG+ S+ A E + AGAS VQ+ Sbjct: 222 EALHPLAVELIWEAASAV--HIPIIGVGGVSSIDDALELMMAGASAVQVG 269 >UniRef50_A8MJK5 Dihydroorotate dehydrogenase family protein n=1 Tax=Alkaliphilus oremlandii OhILAs RepID=A8MJK5_ALKOO Length = 372 Score = 192 bits (489), Expect = 1e-47, Method: Composition-based stats. Identities = 58/299 (19%), Positives = 118/299 (39%), Gaps = 28/299 (9%) Query: 44 AKPVNCMGLTFKNPLGLAAGLD-KDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFR 102 VN +GL+ KNP+ ++AG G + G G++ T+ +P N +PRL + Sbjct: 2 DLSVNFLGLSLKNPIIVSAGPLTGSGSMMRKAIEAGAGAVVTKTIANEIRP-NVRPRLVK 60 Query: 103 LVDAEGLINRMGFNNLGVDNLVENVKKAH-YDGVLGINIGKNKDTPVEQGKDDYLICMEK 161 + GL N ++ ++ + A + V+ NI + + + Sbjct: 61 GRE--GLHNIELYSGFTLEEWENEIAYAKIHGAVVIANILGHTSSEIAYIAQKVEQF--- 115 Query: 162 IYAYAGYIAINISSPNTPGL-RTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAP 220 A + + +S P+ GL + L + A+ ++ +P+ VK++ Sbjct: 116 ---GADAVELGVSCPHGEGLEGVISEPSKLYEFTKAVVDRIK---------IPVMVKLSS 163 Query: 221 DLSEEELIQVADSLVRHNIDGVIATNTT---LDRSLVQGMKNCDQTGGLSGRPLQLKSTE 277 + ++++A + + + +T + +G GG SG ++ Sbjct: 164 N--TVNVVKLARAAEKAGASAISGIDTVRSIAGVDIEKGRVLLPTFGGYSGDAIRPIGLA 221 Query: 278 IIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 I ++ + PI G+GGI + E + GAS VQ+ + I G I ++ + Sbjct: 222 AIASIAQATSI--PICGIGGITNYEHILEYMMLGASTVQVCTSIILNGYEHISTLLDGL 278 >UniRef50_C0WNB5 Dihydroorotate dehydrogenase n=3 Tax=Lactobacillus RepID=C0WNB5_LACBU Length = 315 Score = 192 bits (489), Expect = 1e-47, Method: Composition-based stats. Identities = 72/302 (23%), Positives = 119/302 (39%), Gaps = 24/302 (7%) Query: 44 AKPVNCMGLTFKNPLGLAAGL-DKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFR 102 + N F N L AAG+ + + + G + TP+P+ GN+ PR+ Sbjct: 7 SLKANIGKYRFNNVLLNAAGIRCATTDELTKILRSTAGGCVTKSATPQPREGNESPRMK- 65 Query: 103 LVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKI 162 G IN MG N G+D ++ ++ + + + D L + +I Sbjct: 66 -ATPLGCINSMGLPNHGLDYYLKFAEENQRKNDNQVIL-----SIAGLSVDQNLEMLHQI 119 Query: 163 YA--YAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAP 220 + G +N+S PN G + Y A+++ K I +K+ P Sbjct: 120 QDSLFDGLTELNLSCPNIKGESQIAY------DFEAVRDILTKAFDFFTKD--IGIKLPP 171 Query: 221 DLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQG------MKNCDQTGGLSGRPLQLK 274 + Q+AD L I V + N+ + +V +K GGL G ++ Sbjct: 172 YFDLHQFDQIADVLNEFPIAYVNSINSIGNGLIVNPETESVVLKPKGGFGGLGGDYVKPT 231 Query: 275 STEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVT 334 + +R L L L + IIG GGI S E I GA++VQI + F F+ + I Sbjct: 232 ALANVRGLRLRLKPEIAIIGTGGIKSGRDVFEHILCGANVVQIGTAFGFEDVKIFDRISK 291 Query: 335 HI 336 + Sbjct: 292 EL 293 >UniRef50_B9TAL5 Dihydroorotate dehydrogenase, putative n=1 Tax=Ricinus communis RepID=B9TAL5_RICCO Length = 309 Score = 192 bits (488), Expect = 1e-47, Method: Composition-based stats. Identities = 88/338 (26%), Positives = 151/338 (44%), Gaps = 57/338 (16%) Query: 1 MYYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGL 60 +Y R +L+P+RA L+ + A ++ +GL F P+GL Sbjct: 20 LYETIAR----RLEPQRARSLAILALQLASVFKKNA----TTSSRSTEVLGLRFPGPVGL 71 Query: 61 AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGV 120 AAG DK+GE L + GFG EIGTVT P+PG +LG+ Sbjct: 72 AAGFDKNGELYRYLPSAGFGFAEIGTVTLLPEPG---------------------RSLGI 110 Query: 121 DNLVENVKKAHYDG--VLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNT 178 + ++ + LG++I N+ T + DYL C+ + +A Y+ +N+ Sbjct: 111 HAVANSLARHARGHHIPLGLSISMNRATRPQAMAQDYLACLRAAWQHADYVVLNLGVRAG 170 Query: 179 PGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHN 238 P L ++ L D+L A++ ++ L +P +K+ D + Q+ D ++ Sbjct: 171 PDLHQPEHRNVLADVLEAVRTEKEVLFRQFGYRLPTMIKL--DQARGGTQQLMDMALKAG 228 Query: 239 IDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGI 298 I+GV+ L G + + + ++ L GR+PI+ VGGI Sbjct: 229 IEGVV----------------------LCGAGSRPTTL--LEQMVKTLAGRIPIVAVGGI 264 Query: 299 DSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + A +++AAGASLVQ+++G + GP LI ++ + Sbjct: 265 RTPQDAADRLAAGASLVQVHTGLMQSGPKLISQMNAFL 302 >UniRef50_B5YA20 Dihydroorotate dehydrogenase (Dihydroorotate oxidase)(Dhodehase) (Dhodase) (Dhod) n=1 Tax=Coprothermobacter proteolyticus DSM 5265 RepID=B5YA20_COPPD Length = 274 Score = 192 bits (487), Expect = 2e-47, Method: Composition-based stats. Identities = 62/294 (21%), Positives = 112/294 (38%), Gaps = 26/294 (8%) Query: 46 PVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVD 105 V LT KNP ++G + D + FG+ T+T P+ GN PRL Sbjct: 4 AVRLKKLTLKNPFIASSGTCGYADA-DLIPLDKFGAAVTKTITLLPRQGNRPPRLVE--T 60 Query: 106 AEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAY 165 GL+N +G N+G++ + + L +++G ++ Y Sbjct: 61 PAGLVNSIGLQNMGLEAFKQFLTDFKKPTTLIVSVGGESPEDFATIVEEL-----NTYDL 115 Query: 166 AGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEE 225 +N+S PN GE + + N K P+ VK++P E Sbjct: 116 IDAFELNLSCPNVK-----TGGEVVGKDYVTVSNILEASLKSTTK--PLLVKLSPF--TE 166 Query: 226 ELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKN---CDQTGGLSGRPLQLKSTEIIRRL 282 +L ++ ++ + NT + +GGLSG + I + Sbjct: 167 QLDKILQH-WESKVEAFVLFNTFPAMDIDPRSGKPVLGAVSGGLSGPAIYPIVLNSIYKY 225 Query: 283 SLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 S ++ GGI + A++ I AGA ++I +G ++ P I+ ++ + Sbjct: 226 SKA----HTLVASGGIATTDIAKKFIMAGARALEIGTGNLW-NPAFIEMLLKEV 274 >UniRef50_C9M6H2 Dihydroorotate oxidase n=2 Tax=Synergistaceae RepID=C9M6H2_9BACT Length = 317 Score = 191 bits (486), Expect = 3e-47, Method: Composition-based stats. Identities = 59/307 (19%), Positives = 120/307 (39%), Gaps = 38/307 (12%) Query: 43 PAKPVNCMGLTFKNPLGLAAGLDKD------GECIDALGAMGFGSIEIGTVTPRPQPGND 96 + GL +PL +A+G+ GE +D G++ +T P+PGN Sbjct: 5 SKLTCHVGGLDLTSPLVIASGIWPYEKEYWAGEYLDF-----AGAVCSKAITADPRPGNP 59 Query: 97 KPRLFRLVDAEGLINRMGFNNLGVDNL----VENVKKAHYDGVLGINIGKNKDTPVEQGK 152 R++ G++N +G N G + + ++ Y L +N+ + +E+ Sbjct: 60 GTRVWE--TPCGMLNSIGLQNEGAGSFFGGTLGRLRS--YGKPLLLNVSMESSSDLERIL 115 Query: 153 DDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYV 212 D ME + + +N+S PN + +G A++ + Sbjct: 116 D----AMEPVAPSVDCVELNVSCPNV-DQGCMSWGVDPALTAQAVQQVRRR------WSG 164 Query: 213 PIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQ---GMKNCDQTGGLSGR 269 P+ VK+ P + VA + ++ NT L ++ GLSG Sbjct: 165 PLWVKLTPQAPDP--CAVAKAAQDAGASALVVANTWLGAAIDTVKARPAFDRVVAGLSGP 222 Query: 270 PLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLI 329 + + ++ ++ + +P++G GG+ S +A + AGA+ V++ F ++ Sbjct: 223 AIFPLALRMVWQVCGAV--DIPVVGCGGVASADSAVAMLMAGAAAVEVGMAL-FSDFSVL 279 Query: 330 KEIVTHI 336 + I + Sbjct: 280 ERIARGL 286 >UniRef50_P25889 Uncharacterized protein yeiA n=116 Tax=Bacteria RepID=YEIA_ECOLI Length = 411 Score = 190 bits (484), Expect = 4e-47, Method: Composition-based stats. Identities = 61/315 (19%), Positives = 122/315 (38%), Gaps = 39/315 (12%) Query: 43 PAKPVNCMGLTFKNPLGLAAGLDKDG-ECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLF 101 + G+ F NP L++ + E G+G + T+ PR Sbjct: 4 KDLSITFCGVKFPNPFCLSSSPVGNCYEMCAKAYDTGWGGVVFKTIGFF-IANEVSPRFD 62 Query: 102 RLV-DAEGLI---NRMGFNNLGVD---NLVENVKKAHYDGVLGINIGKNKDTPVEQGKDD 154 LV + G I N ++ + +K+ + D VL +I EQ ++ Sbjct: 63 HLVKEDTGFIGFKNMEQIAEHPLEENLAALRRLKEDYPDKVLIASIMG----ENEQQWEE 118 Query: 155 YLICMEKIYAYAGYIAINISSP----NTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHK 210 +++ A I N S P + G Q E ++ A+K Sbjct: 119 LARLVQEAG--ADMIECNFSCPQMTSHAMGSDVGQSPELVEKYCRAVKR---------GS 167 Query: 211 YVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKN--------CDQ 262 +P+ K+ P++ + + +VA + R DG+ A NT + + + Sbjct: 168 TLPMLAKMTPNIGD--MCEVALAAKRGGADGIAAINTVKSITNIDLNQKIGMPIVNGKSS 225 Query: 263 TGGLSGRPLQLKSTEIIRRLSLELN-GRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGF 321 G SG+ ++ + I+++ PI G+GGI++ A E + GA+ +Q+ +G Sbjct: 226 ISGYSGKAVKPIALRFIQQMRTHPELRDFPISGIGGIETWEDAAEFLLLGAATLQVTTGI 285 Query: 322 IFKGPPLIKEIVTHI 336 + G +++++ + + Sbjct: 286 MQYGYRIVEDMASGL 300 >UniRef50_D0JBI0 Dihydroorotate dehydrogenase n=2 Tax=Blattabacterium RepID=D0JBI0_BLASB Length = 320 Score = 190 bits (483), Expect = 6e-47, Method: Composition-based stats. Identities = 68/298 (22%), Positives = 119/298 (39%), Gaps = 23/298 (7%) Query: 46 PVNCMGLTFKNPLGLAAG-LDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLV 104 G+ + + A+G L G+ + L G+I + T +P+ GN KPR F Sbjct: 16 SARINGIQLSSCIMNASGALCTTGQELSDLLDSSSGAIVTKSCTRQPRKGNIKPRYFEWN 75 Query: 105 DAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYA 164 G IN MG NLG+D + +++ + ++I + +L+ + Sbjct: 76 V--GSINSMGLPNLGIDFYLNFLEEKKTKKPVFLSISGLSIEEI-----FFLLKKANFSS 128 Query: 165 YAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSE 224 I +N+S PN E L L I + ++ + K P+ +K+ P E Sbjct: 129 KITAIELNLSCPNL-------QEEILGYDLYKIYDFLENVFKFNEK--PLGIKLPPYFKE 179 Query: 225 EELIQVADSLVRHNIDGVIATNTTLDRSLVQGM------KNCDQTGGLSGRPLQLKSTEI 278 E + ++ L + I V N+ + V + + GG+ G ++ + Sbjct: 180 EYIKNMSLILNQFPIVFVTCINSLPNGIFVDPRNETSVIQPRNGFGGIGGSIIKPFALAN 239 Query: 279 IRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 IR+ L + IIG GGI E I GAS VQI + + +G + + + Sbjct: 240 IRKFYTYLRKDISIIGCGGISYGKDIFEHILCGASAVQIGTQLMKEGISVFERLKKEF 297 >UniRef50_A5IK84 Dihydroorotate dehydrogenase n=10 Tax=Thermotogaceae RepID=PYRD_THEP1 Length = 270 Score = 188 bits (478), Expect = 2e-46, Method: Composition-based stats. Identities = 67/290 (23%), Positives = 115/290 (39%), Gaps = 31/290 (10%) Query: 52 LTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLIN 111 L K PL L +G GE + + G + + TVT P+ GN PR+ +IN Sbjct: 2 LELKPPLVLLSGPAGFGEYLKLMDHRYVGGVLLKTVTLHPKEGNPTPRMA--DSDFYVIN 59 Query: 112 RMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAG---Y 168 R+G N G+ VEN+ + + ++G ++YL A Sbjct: 60 RIGLENPGIHAFVENIPELP--VPMIASLGG-------DSFEEYLEVARVFKKVADRFYA 110 Query: 169 IAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEE 226 + N S PN GL ++ E LL ++ + D + K+ + Sbjct: 111 VEFNFSCPNVKEGGLSIVKNAEEWKKLLNTLRKELPDSF--------LIAKV--GVEGIF 160 Query: 227 LIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLEL 286 + A+ +++ DG+ NT + GGLSG L+ + + + Sbjct: 161 VEDAAEFVMKTGWDGITLVNTVRGLHFEKDTM---ILGGLSGPVLKPIALRAVYEVKKRF 217 Query: 287 NGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 +I GG+ SV A E + GA ++ + S FK P +++EI ++ Sbjct: 218 PELF-VIASGGVYSVKDAEEFLKVGADVIGVGSAL-FKDPGVVEEIGKYL 265 >UniRef50_Q8TXU6 Dihydroorotate dehydrogenase n=1 Tax=Methanopyrus kandleri RepID=Q8TXU6_METKA Length = 318 Score = 188 bits (477), Expect = 3e-46, Method: Composition-based stats. Identities = 69/300 (23%), Positives = 118/300 (39%), Gaps = 20/300 (6%) Query: 46 PVNCMGLTFKNPLGLAAG-LDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLV 104 PV +G + +P+ A+G L ++ G +I TVT P+ G+ P + Sbjct: 3 PVEVLGKRWAHPIACASGALAAHRPGMENAVLRGAAAIFTKTVTESPREGHPGPVFVDYL 62 Query: 105 DAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYA 164 D +N MG N G D +V +++ + + + D P + Sbjct: 63 DEGYALNAMGLPNPGPDRMVVEIEEFRDEFDVPVYASVAADGPEG-----FKRLARAFSG 117 Query: 165 YAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSE 224 A + +N+S P+ YG L A+ P++VK+ P++ Sbjct: 118 VADGLELNVSCPH----AGKGYGAELGSDPEAVAEITEAAVRAFDG--PVSVKLTPNVDR 171 Query: 225 EELIQVADSLVRHNIDGVIATNTTLDRSLVQ----GMKNCDQTGGLSGRPLQLKSTEIIR 280 E L++VA + + + + A NT + GGLSG L+ + ++ Sbjct: 172 ETLLEVAAAAIDAGAEALTAVNTLGPGLRIDLRTASPVLGAGVGGLSGPALKPIALRVVA 231 Query: 281 RLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIK----EIVTHI 336 L+LE + IIGVGGI + E + AGA VQ+ + K I I+ + Sbjct: 232 DLALEFGEEVEIIGVGGIRNGEDVVEFLFAGAKAVQVATAAREKDFGDIAMETSHILKEL 291 >UniRef50_A0LUF8 Dihydroorotate oxidase B, catalytic subunit n=6 Tax=Actinomycetales RepID=A0LUF8_ACIC1 Length = 351 Score = 187 bits (475), Expect = 5e-46, Method: Composition-based stats. Identities = 64/308 (20%), Positives = 114/308 (37%), Gaps = 22/308 (7%) Query: 35 EALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDG-ECIDALGAMGFGSIEIGTVTPRPQP 93 + NP+ A+G G E + G++ ++ P+ Sbjct: 17 PRRTAAPAVDLTTQLGSVVLPNPVTTASGCAAAGRELGQFVDVSTLGAVVTKSIMLAPRA 76 Query: 94 GNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKK--AHYDGVLGINIGKNKDTPVEQG 151 G PR+ GL+N +G G+D +E+ A + ++I + Sbjct: 77 GRPTPRMAE--TPSGLLNGIGLQGPGIDEFLEHDLPWLAEHGARAIVSIAGSSVGEYAAL 134 Query: 152 KDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKY 211 + + +NIS PN G+ A ++ Sbjct: 135 AARLRGAAPVVA-----LEVNISCPNVED-----RGQVFACDPRAASAVLAAVREAADPA 184 Query: 212 VPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQ---GMKNCDQTGGLSG 268 VP+ K++PD+++ ++ VA + V DG+ NT L + TGGLSG Sbjct: 185 VPVFAKLSPDVTD--IVAVATACVAAGADGLSLINTLLGLVIDTETLRPALSGVTGGLSG 242 Query: 269 RPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPL 328 ++ + + ++ L +PIIG+GGI S + A + + AGA V + + IF P Sbjct: 243 PAIRPVAVRCVWQVHAAL-PDVPIIGMGGIRSGLDALQFLLAGACAVSVGTE-IFHDPSA 300 Query: 329 IKEIVTHI 336 I + Sbjct: 301 PARIRDEL 308 >UniRef50_A3DM44 Dihydroorotate oxidase B, catalytic subunit n=1 Tax=Staphylothermus marinus F1 RepID=A3DM44_STAMF Length = 301 Score = 186 bits (473), Expect = 9e-46, Method: Composition-based stats. Identities = 68/298 (22%), Positives = 122/298 (40%), Gaps = 25/298 (8%) Query: 44 AKPVNCMGLTFKNPLGLAAGLDKDGE-CIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFR 102 G+ FK+P+ A+G+ + L G I T+T +P+ G P Sbjct: 2 DLTTKVTGIVFKHPIMNASGILASSINGVGILAKTGVAGIVTKTLTLKPREGYLPP--IT 59 Query: 103 LVDAEGLINRMGFNNLGVDNLVENVKK-AHYDGVLGINIGKNKDTPVEQGKDDYLICMEK 161 + GL+N +G N G+D + V++ Y ++IG + + + Sbjct: 60 IPLDYGLLNAVGLANPGIDAVNVLVEEIHKYGLPAIVSIGGRDPREFQILAE------KA 113 Query: 162 IYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPD 221 + A + +N+S P+TPG A D++L + L +P+ K+ Sbjct: 114 LDARPEALELNLSCPHTPG--FGVDTVATDEVLKHV-----ALNVSSVSNIPVWGKLG-- 164 Query: 222 LSEEELIQVADSLVRHNIDGVIATNTTLDRSLV---QGMKNCDQTGGLSGRPLQLKSTEI 278 +I+ ++ L+ + +D V+ NT + GGLSG + + Sbjct: 165 -FSRRIIRESEILLNNGVDAVVLINTLPGMFIDVYVGKPVLTHGFGGLSGPAIHPVAVYS 223 Query: 279 IRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + ++ EL IIGVGG+ + E + AGA +QI +GF G ++ I+ I Sbjct: 224 VYKVYEELGAE--IIGVGGVIDWKTSVELLLAGAKAIQIGTGFYMVGYNIVNNILDGI 279 >UniRef50_C6Q0J2 Dihydroorotate dehydrogenase family protein n=1 Tax=Clostridium carboxidivorans P7 RepID=C6Q0J2_9CLOT Length = 360 Score = 185 bits (470), Expect = 2e-45, Method: Composition-based stats. Identities = 61/304 (20%), Positives = 118/304 (38%), Gaps = 40/304 (13%) Query: 42 VPAKPVNCMGLTFKNPLGLAAGL-DKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRL 100 + V+ G+ KNP+ A+G ++ +C+ G G++ T++ + +P + Sbjct: 1 MANLNVDLHGIKIKNPIMPASGPQVRNADCMLECVKQGVGALVTKTISEKFVRT-ARPCM 59 Query: 101 FRLVDAEGLINRMGFNNLGVDNLVEN--VKKAHYDGVLGINIGKNKDTPVEQGKDDYLIC 158 +N ++ L V+ VE K Y +++G + Sbjct: 60 QE-TKDGAFLNSELWSELSVEQWVEKGYSKCKSYGVPFIVSLG--------YTAKEIEKV 110 Query: 159 MEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKI 218 + I YA I I+ ++ L ++ + L+ P+ +KI Sbjct: 111 LPIITPYADIIEISTH--------------YMEKDLESV---VDSLKIASKSDKPVYIKI 153 Query: 219 APDLSEEELIQVADSLVRHNIDGVIATNTTL---DRSLVQGMKNCDQ---TGGLSGRPLQ 272 +P +++ + LV G +A N+ + G+ G LSG+ L Sbjct: 154 SPGITK--IGWYVKRLVEEGAAGFVAINSLGPCLHIDVETGLPYLGGEKGYGWLSGKSLN 211 Query: 273 LKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 + + ++ + ++P+IGVGGI S A I AGAS VQI + I +G + + Sbjct: 212 PIALRYVYSIANSV--KVPVIGVGGISSGEDAVAMIMAGASAVQICTAAILEGNGVYSRV 269 Query: 333 VTHI 336 + Sbjct: 270 SNEL 273 >UniRef50_B0VIM3 Dihydroorotate dehydrogenase, catalytic subunit (Dihydroorotate oxidase) (DHOdehase) (DHODase) (DHOD) n=1 Tax=Candidatus Cloacamonas acidaminovorans RepID=B0VIM3_9BACT Length = 305 Score = 185 bits (470), Expect = 2e-45, Method: Composition-based stats. Identities = 54/300 (18%), Positives = 114/300 (38%), Gaps = 30/300 (10%) Query: 45 KPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLV 104 + L +P+ +A+G E +D + G+ T+T P+ GN PRL+ Sbjct: 8 LQTSLGRLKVNSPVTVASGTFA-LENLDFIEQDHLGAYVCKTITRYPKKGNPPPRLYE-- 64 Query: 105 DAEGLINRMGFNNLGVDNLVENVKKAHYD---GVLGINIGKNKDTPVEQGKDDYLICMEK 161 GL+N +G N G+D + + L ++ + Q + Sbjct: 65 TEAGLLNSIGLQNPGLDKFIAEDLPVLRETLTVPLIVSFSGSSLKEFVQMLECLEK---- 120 Query: 162 IYAYAGYIAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIA 219 +N+S PN G+ + ++ L + + VK++ Sbjct: 121 -QEGISGYEVNVSCPNVENEGIAFGIDPDVVNKLCALLSPLTERE---------LIVKLS 170 Query: 220 PDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQG---MKNCDQTGGLSGRPLQLKST 276 P++++ + +A + + NT ++ + GG SG ++ + Sbjct: 171 PNVTD--IAVIAKAAEEGGATAISLINTIWGMAIDYRNGKSRIKKGIGGYSGIGIKPLAL 228 Query: 277 EIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + R + + ++P+I +GGI + A E AGAS++ + + F P + ++ + Sbjct: 229 ALTYRAAQAV--KIPVIAMGGIYNWQDALEFFWAGASMIALGTAN-FIDPLAVDKVYEGL 285 >UniRef50_A6DND8 Dihydroorotate dehydrogenase n=1 Tax=Lentisphaera araneosa HTCC2155 RepID=A6DND8_9BACT Length = 358 Score = 185 bits (470), Expect = 2e-45, Method: Composition-based stats. Identities = 86/360 (23%), Positives = 142/360 (39%), Gaps = 48/360 (13%) Query: 4 PFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAAG 63 + +LF + L + P + P GL F+N LG AAG Sbjct: 17 KLLPPSLFMKVYSSGRNKFIKDLAALQLDPVKGDFN------PTELCGLKFRNDLGNAAG 70 Query: 64 LDKDGECIDALGAMGFGSIEIGTVTPRPQPGN-------DKPRLFRLVDAEGLINRMGFN 116 LDKDG +D +G G +GTV +P GN ++ L ++ +N +G Sbjct: 71 LDKDGSLLDFNYNLGAGFAVVGTVLDKPHTGNLFNAFGKERNPWAPLPNSHSALNSLGLP 130 Query: 117 NLGVDNLVENVKK-----AHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAI 171 +LGVD V+N+K D +G++I + E L C++K A +I I Sbjct: 131 SLGVDVAVDNIKAFQDRVQPQDFPIGVSIMGHPAQEGEVKLQGVLDCVKKSLPVADFIEI 190 Query: 172 NISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVA 231 N S PN G A+ + ++A+ + D VPI +K+ S + +V Sbjct: 191 NESCPNVKG----HDSSAMYERISAVMDVATD-------QVPIFIKLG---SLDHAEEVL 236 Query: 232 DSLVRHNIDGVIATNTTLDRSLVQGMKNCDQ-----------TGGLSGRPLQLKSTEIIR 280 + GV+ NT D + + +GGLSG ++ + + ++ Sbjct: 237 AKFAEMKVAGVVLLNTQRDYDFYRPKLDKGDHKVFDFYTKEFSGGLSGTIIRQTALDAVK 296 Query: 281 RLSLELNGRLP---IIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLI-KEIVTHI 336 + + +I VGGI + E A L + YS F+ + L +I H+ Sbjct: 297 EAKAIIEQQKLDLKLIHVGGIGNNQDVCESRKY-AELREWYSLFMERLFELPADQIYKHL 355 >UniRef50_C5CHS6 Dihydroorotate dehydrogenase family protein n=1 Tax=Kosmotoga olearia TBF 19.5.1 RepID=C5CHS6_KOSOT Length = 361 Score = 184 bits (467), Expect = 4e-45, Method: Composition-based stats. Identities = 60/301 (19%), Positives = 115/301 (38%), Gaps = 37/301 (12%) Query: 44 AKPVNCMGLTFKNPLGLAAGLD-KDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFR 102 GL NP+ A+G D + + AL G G++ T++ + PR Sbjct: 2 DLTTKIAGLQLANPVMPASGPLTGDDQKMLALTDFGLGAMVTKTISTKAAE---VPRPCI 58 Query: 103 LVDAEGLINRMGFNNLGVDNLV-ENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEK 161 + ++N + + E + K L + + + +D + + Sbjct: 59 IAGKNYIMNTELWTEYPPEKWKGEFIPKFREKSSLPLIVS------LGYTVEDLEVLVPM 112 Query: 162 IYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPD 221 A ++ E + L+ +K + P+ +K P Sbjct: 113 FDDLADAFELSTH-------YVADDPELMKHLIRTVKKHTD---------KPVFLKFDPS 156 Query: 222 LSEEELIQVADSLVRHNIDGVIATNTTL------DRSLVQGMKNCDQTGGLSGRPLQLKS 275 + E E+ +A ++ DG++A N+ + + G +SG ++ + Sbjct: 157 VPEPEV--MAKAVEEAGGDGIVAINSLGPGYPLYRELKSSPLGSTHGFGWISGPVIKPIA 214 Query: 276 TEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTH 335 +++R++ N LPIIGVGGI S + I AGAS VQ+ SG + G + K+I+ Sbjct: 215 LAMVKRVASSCN--LPIIGVGGISSADDVIDFIMAGASAVQLLSGALLYGKSIYKKIIAD 272 Query: 336 I 336 + Sbjct: 273 L 273 >UniRef50_O08358 Dihydroorotate dehydrogenase n=12 Tax=Sulfolobaceae RepID=PYRD_SULAC Length = 291 Score = 183 bits (464), Expect = 8e-45, Method: Composition-based stats. Identities = 67/295 (22%), Positives = 128/295 (43%), Gaps = 31/295 (10%) Query: 47 VNCMGLTFKNPLGLAAGL-DKDGECIDA-LGAMGFGSIEIGTVTPRPQPGNDKPRLFRLV 104 + G+ F++P+ +A+G+ E + +I T+T P + P ++ Sbjct: 2 IQVAGVNFEDPIVIASGIVPPTKEYMQNVCEKYEPSAITSKTLTYSPLEPHRSPTFVKI- 60 Query: 105 DAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYA 164 +N +G N G+ ++ ++ + L I+IG + ++Y+ + KI Sbjct: 61 SDNCYLNAIGLGNPGI-QILRDLGEIKCK--LIISIGGS-------NVNEYIDAVSKIND 110 Query: 165 YAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSE 224 I +N+SSPN G + LT ++ +++++ K P+ VK+ P Sbjct: 111 IPVMIELNVSSPNRRGFG--------ESNLTYVEEIVKNVKSIVKK--PVFVKLGP---W 157 Query: 225 EELIQVADSLVRHNIDGVIATNTTLDRSLV---QGMKNCDQTGGLSGRPLQLKSTEIIRR 281 + ++++A + DG+ NT + TGG+SG+ + + +I Sbjct: 158 DNIVEIAGRALSAGADGLTLINTLKGMLIDVEDFKPILSYGTGGISGKCIHALAVRVIHD 217 Query: 282 LSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + E IIGVGG+ A E I+ GA LV + + + KG +I+EI I Sbjct: 218 VFKEYEPE--IIGVGGVFDWRDAIELISVGAKLVGLGTVLVEKGFDVIREIREGI 270 >UniRef50_Q9YFI6 Dihydroorotate dehydrogenase n=3 Tax=Desulfurococcales RepID=PYRD_AERPE Length = 306 Score = 183 bits (464), Expect = 1e-44, Method: Composition-based stats. Identities = 58/303 (19%), Positives = 118/303 (38%), Gaps = 24/303 (7%) Query: 39 RQKVPAKPVNCMGLTFKNPLGLAAGLDK-DGECIDALGAMGFGSIEIGTVTPRPQPGNDK 97 P ++ GL + P+G A+G+ + + G G +VT +P+ G + Sbjct: 1 MYSQPELSISIAGLRLQRPVGNASGILGWEPREARLVEEGGGGFFVAKSVTYQPRKGYPQ 60 Query: 98 PRLFRLVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLI 157 P L A G++N +G N G + + + + + + + +++ Sbjct: 61 PHL--YPVAGGIVNAVGLANPGFREASKMLAQTVEEASIPVIA-----SIAGGAPGEWVE 113 Query: 158 CMEKIYA-YAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAV 216 + + +N+S P+ G G L A+ + + + + +P+ Sbjct: 114 MASTLEEAGVSAVELNLSCPHFAG-----GGLELGQDPAAVASVVSAVASTL--RIPVIA 166 Query: 217 KIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLV---QGMKNCDQTGGLSGRPLQL 273 K+ + L+ A + G+ N+ + + ++ GGLSG+P+ Sbjct: 167 KLG---YSDRLVDAASKALEAGARGLTLINSMRAMKIDVYAKKPVLGNRVGGLSGKPIHP 223 Query: 274 KSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIV 333 + + + E I GG++S A E AGA VQ+ + FI GP +++ IV Sbjct: 224 IAVRAVYEVYGETRAD--IFAAGGVESWEDAVEFYLAGAKAVQVGAAFITIGPHVLRSIV 281 Query: 334 THI 336 + Sbjct: 282 EGV 284 >UniRef50_Q73P17 Dihydroorotate dehydrogenase/oxidoreductase, FAD-binding n=1 Tax=Treponema denticola RepID=Q73P17_TREDE Length = 591 Score = 182 bits (462), Expect = 2e-44, Method: Composition-based stats. Identities = 59/273 (21%), Positives = 112/273 (41%), Gaps = 28/273 (10%) Query: 62 AGLDKDGECIDA--LGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLG 119 +G+ + +GFG + + P PGN +P L + N +G N G Sbjct: 31 SGVLSTKPNLIRYCADELGFGLVTTKSFQVLPNPGNREPILCE-PELGCFGNSVGLRNCG 89 Query: 120 VDNLVENVKKAHY--DGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPN 177 ++ V+ +K+ +N+ + P +D++ ++ A +N S P+ Sbjct: 90 MEQAVKELKELRSSWKTDSILNVSLSASNP-----EDFISLLKGFEELADCFELNFSCPH 144 Query: 178 TP---GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSL 234 G + + IK D VPI VK+ P++ E++ +A ++ Sbjct: 145 ASAGFGASIGCDPAIAAEYVKIIKKALPDCA------VPIFVKLTPNV--EDIGAIASAV 196 Query: 235 VRHNIDGVIATNTTLDRSLVQGMKNC-------DQTGGLSGRPLQLKSTEIIRRLSLELN 287 + DG+ A NT + ++ GG+SG + ++ E I ++ + Sbjct: 197 IEAGADGITAINTVGPKVYIEPHSGKPILQNKLGGKGGMSGAWVFPRALECIGQIRKAVG 256 Query: 288 GRLPIIGVGGIDSVIAAREKIAAGASLVQIYSG 320 +PIIG+GG+ + A E + AGA ++ I S Sbjct: 257 EEIPIIGMGGVMTGAQAAELVRAGADIIGIGSA 289 >UniRef50_D2QWH7 Dihydroorotate dehydrogenase family protein n=6 Tax=Planctomycetaceae RepID=D2QWH7_9PLAN Length = 315 Score = 182 bits (461), Expect = 2e-44, Method: Composition-based stats. Identities = 66/300 (22%), Positives = 120/300 (40%), Gaps = 28/300 (9%) Query: 44 AKPVNCMGLTFKNPLGLAAGLDKDGECIDALGA-MGFGSIEIGTVTPRPQPGNDKPRLFR 102 V L +NP+ A+G +++L G I TVT +P+ GN R Sbjct: 12 DLSVTLGRLRLRNPILTASGTFGYAREMESLVDFSKLGGILPKTVTQQPRAGNTPWRTVE 71 Query: 103 LVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKI 162 GL+N +G +N G++ + + Y G L +I + ++++ ++ Sbjct: 72 --TTAGLLNAIGLDNDGIETFIAH--HMPYLGSLPTSIIVS---IAGSNHNEFVAMAGRL 124 Query: 163 YAYAGY--IAINISSPNTP-GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIA 219 G I +NIS PN G+ + L++ PI K+ Sbjct: 125 SDIDGIAAIELNISCPNVAHGIDFGADASLCEKLVSDCVKATRH---------PILAKLT 175 Query: 220 PDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQG---MKNCDQTGGLSGRPLQLKST 276 P+++ + VA D + NT ++ + GGLSG ++ + Sbjct: 176 PNVT--RIADVAKGAANGGADALSLINTVQGMAIDWRKQKPLLGNVMGGLSGPAIKPIAL 233 Query: 277 EIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + ++ ++ PIIG+GGI ++ E I AGAS VQI + + P + ++ + Sbjct: 234 RCVHQVRQAVS--TPIIGIGGIATIDDVMEFIVAGASAVQIGTANYY-DPTVTMKLAAAL 290 >UniRef50_A6LJ97 Dihydroorotate dehydrogenase family protein n=2 Tax=Thermosipho RepID=A6LJ97_THEM4 Length = 360 Score = 181 bits (460), Expect = 3e-44, Method: Composition-based stats. Identities = 57/303 (18%), Positives = 119/303 (39%), Gaps = 40/303 (13%) Query: 44 AKPVNCMGLTFKNPLGLAAGLD-KDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFR 102 G+ +NPL A+G D E I + + G G+I T++ + N PR Sbjct: 2 DLSTEISGIKIENPLMPASGPLVGDYEKIKFIDSTGVGAIVTKTISTKA--ANV-PRPCI 58 Query: 103 LVDAEGLINRMGFNNLGVDNLVENVK---KAHYDGVLGINIGKNKDTPVEQGKDDYLICM 159 + ++N ++ L + ++ + K L +++G +D I + Sbjct: 59 YGENNFVMNAELWSELPPETWIKEILPKLKNELKKPLIVSVG--------YTIEDMEILI 110 Query: 160 EKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIA 219 ++ YA I+ + I N ++ +K PI +K++ Sbjct: 111 PQLNEYADAFEISTH--------------YVGKDYNTIANIVKAIRKNTNK--PIFMKLS 154 Query: 220 PDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTG------GLSGRPLQL 273 P + + ++ +++ + +G++A N+ + G LSG ++ Sbjct: 155 PHIPDP--VEFTKTILENGANGIVAINSWGPTMKIDIKNRKTLIGNEKGQVWLSGPVIKP 212 Query: 274 KSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIV 333 + I++ + + IIGVGGI S E + +GA VQ+ S + G + ++I+ Sbjct: 213 IALSIVKTIRDAF-PDITIIGVGGIKSAEDVIEFLLSGADAVQLLSSALIFGKDIYEKIL 271 Query: 334 THI 336 + Sbjct: 272 NQL 274 >UniRef50_A3U0T3 Probable dihydroorotate dehydrogenase, catalytic subunit n=1 Tax=Oceanicola batsensis HTCC2597 RepID=A3U0T3_9RHOB Length = 314 Score = 181 bits (459), Expect = 4e-44, Method: Composition-based stats. Identities = 65/285 (22%), Positives = 117/285 (41%), Gaps = 29/285 (10%) Query: 42 VPAKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMG-FGSIEIGTVTPRPQPGNDKPRL 100 + V G+ KNP+ A+G E + + +G G+I + T+TP + G PR+ Sbjct: 1 MVDLSVTVGGVRMKNPVMPASGSI--AEGMADVVDLGRLGAIVLKTITPDLRQGVKPPRV 58 Query: 101 FRLVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICME 160 D + +G + G D L+ + + + DT +D+ Sbjct: 59 VEYTD--ATLFSIGIPSKGPDYLLNHTVPFFDKFGPPVIASISADT-----VEDFGKLAG 111 Query: 161 KI-YAYAGYIAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVK 217 I I NIS PN G A ++TA+K + +PI K Sbjct: 112 YITDPRIAAIEANISCPNLRAHGRAFGMDPVASAQVITAMKA---------NTTLPIWAK 162 Query: 218 IAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGM---KNCDQTGGLSGRPLQLK 274 + P++ + + ++A + D VI N L ++ + + GGL+G ++ Sbjct: 163 LTPNVGD--IAEMARCVEGAGADAVITANAILGMAIDAETMTPRLGNVVGGLTGPAVKPV 220 Query: 275 STEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYS 319 ++ + + + ++P+IG GGI + E + AGAS VQI + Sbjct: 221 ILRMVNQCAEAV--KIPVIGCGGIATGEDVVEYMLAGASAVQIGT 263 >UniRef50_Q01P61 Dihydropyrimidine dehydrogenase (NADP+) / dihydrouracil dehydrogenase (NAD+) / dihydroorotate oxidase B, catalytic subunit n=94 Tax=Bacteria RepID=Q01P61_SOLUE Length = 446 Score = 180 bits (457), Expect = 7e-44, Method: Composition-based stats. Identities = 59/310 (19%), Positives = 114/310 (36%), Gaps = 27/310 (8%) Query: 42 VPAKPVNCMGLTFKNPLGLAAGLDKD-GECIDALGAMGFGSIEIGTVTPRPQPGNDKPRL 100 + N G+ NP LA+G + GE I G+G T+ P N R Sbjct: 1 MADLSTNFAGIRCPNPFWLASGPPTNCGEQIMRAFDAGWGGAVWKTIG-EPIV-NVSSRY 58 Query: 101 FRLVDAEGLINRMGFNN------LGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDD 154 + + MG NN ++ + + + I + D Sbjct: 59 SSVDWNGQRM--MGLNNIELISDRPIETNLREITEVKKRYPKHAVIASLMVESTREAWHD 116 Query: 155 YLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPI 214 + E A A + +N P+ G+ G A+ + ++ + P+ Sbjct: 117 IVKRSE--DAGADGLELNFGCPH--GMSERGMGAAVGQVPDYSCMITEWVKEV--ARTPV 170 Query: 215 AVKIAPDLSEEELIQVADSLVRHNIDGVIATNTT---LDRSLVQGMKNCDQ-----TGGL 266 VK+ P++++ + VA + R D + A NT L + GG Sbjct: 171 LVKLTPNITD--IRAVARAAKRGRADALSAINTINSITGIDLDTFTPRPNVGGKTSHGGY 228 Query: 267 SGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGP 326 G ++ + ++++++ + LPI G+GGI A E I G VQ+ + + G Sbjct: 229 CGPAVKPIALHLVQQIASDPAVGLPISGIGGIGGWREAAEFILLGCGTVQVCTAAMHYGF 288 Query: 327 PLIKEIVTHI 336 ++++++ + Sbjct: 289 RIVEDMIDGL 298 >UniRef50_D0U5Z4 Dihydroorotate dehydrogenase subfamily 1 family protein n=1 Tax=uncultured actinobacterium RepID=D0U5Z4_9ACTN Length = 324 Score = 179 bits (455), Expect = 1e-43, Method: Composition-based stats. Identities = 70/312 (22%), Positives = 122/312 (39%), Gaps = 29/312 (9%) Query: 37 LVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDGECID-ALGAMGFGSIEIGTVTPRPQPGN 95 + +K V + FK+P+ LA+G + ++ G+I + +++ GN Sbjct: 1 MRGKKHFDHSVRVDDVEFKSPVLLASGTAGHADELEPYFPLSKIGAIVVKSMSSFEWAGN 60 Query: 96 DKPRLFRLVDAEGLINRMGFNNLGVDNLVEN-VKKAHYDGVLGINIGKNKDTPVEQGKDD 154 PRL G++N +G LGV + +E+ + + + + DD Sbjct: 61 KAPRLR--PTNGGMLNAVGLQGLGVAHWIEHDLPRLKKVKATIV------ASIWGFSIDD 112 Query: 155 YLICMEKIYAYA---GYIAINISSPN----TPGLRTLQYGEALDDLLTAIKNKQNDLQAM 207 Y + + I IN+S PN + T A D+ L+A ++ Sbjct: 113 YRSAASLLSEVSTDLAAIEINLSCPNIGSSSKAANTPHGIFAHDEDLSA-----EIVRVC 167 Query: 208 HHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLS 267 VP+ K++P+ ++ VA ++ + V NT L ++ G Sbjct: 168 SVAKVPLWAKLSPNTD--RVVDVAAAVSKAGCQAVTLINTALGLAIDVETGLPALGNGGG 225 Query: 268 GRP---LQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFK 324 G + + I + L RLPIIGVGGI + A E + AGAS +Q+ + F Sbjct: 226 GLSGSGIHPIAVRTIFDVRTRL-PRLPIIGVGGIANGEDAIEMMMAGASCIQVGTAT-FA 283 Query: 325 GPPLIKEIVTHI 336 P I + Sbjct: 284 DPRAAMRIDREM 295 >UniRef50_UPI0001C31DA9 dihydroorotate dehydrogenase family protein n=1 Tax=Conexibacter woesei DSM 14684 RepID=UPI0001C31DA9 Length = 303 Score = 179 bits (455), Expect = 1e-43, Method: Composition-based stats. Identities = 65/305 (21%), Positives = 116/305 (38%), Gaps = 32/305 (10%) Query: 43 PAKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAM-----GFGSIEIGTVTPRPQPGNDK 97 P+ P + G+ +P+ +G A G F + TVT P+ GN Sbjct: 4 PSLPTSFCGIELAHPIVNGSGTFDAIAAQRAFGDALVEQFPFAAFVSKTVTVAPREGNPP 63 Query: 98 PRLFRLVDAEGLINRMGFNNLGVDNLV--ENVKKAHYDGVLGINIGKNKDTPVEQGKDDY 155 PRL+ L GLIN +G N G+ + + + A L +N+ V Q + Sbjct: 64 PRLWELP--AGLINSIGLPNKGLAGYLTHDLPELARLPVPLIVNVMGFTREEVAQLVTAF 121 Query: 156 LICMEKIYAYAGYIAINISSPNTP-GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPI 214 + +N+S PN G L+ ++ PI Sbjct: 122 AER-----DEVAALELNVSCPNVETGTIMGSDPTETARLVERVRPLTQ---------KPI 167 Query: 215 AVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKN---CDQTGGLSGRPL 271 VK+ P+ S+ + A DG+ NT +L + TGG+SG + Sbjct: 168 VVKLTPNASDPGAVAEAAEAAGA--DGLSLINTIRGMALDPRTREPWLGAGTGGVSGATV 225 Query: 272 QLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKE 331 + + + ++ ++ P+I +GG+ A + + AGA+LV + + F+ P + Sbjct: 226 RAVALAQVSDVAQRVSI--PLIAMGGVQRGRDADDLLRAGATLVAVGTES-FRDPAAGRR 282 Query: 332 IVTHI 336 + + Sbjct: 283 VAHEL 287 >UniRef50_A9GKC4 Dihydropyrimidine dehydrogenase n=5 Tax=Bacteria RepID=A9GKC4_SORC5 Length = 462 Score = 179 bits (455), Expect = 1e-43, Method: Composition-based stats. Identities = 60/314 (19%), Positives = 125/314 (39%), Gaps = 35/314 (11%) Query: 42 VPAKPVNCMGLTFKNPLGLAAGLDKD-GECIDALGAMGFGSIEIGTVTPRPQPGNDKPRL 100 + ++ G+ NP LA+ + G+ + G+G T+ GN + Sbjct: 1 MADLSIDFAGIKSPNPFWLASAPPTNTGDQVRRAFDAGWGGAVWKTL------GNPIVNV 54 Query: 101 FRLVDAEGLINR--MGFNN------LGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGK 152 N MG NN +D ++ +++ I + + + K Sbjct: 55 SSRFGGIDYGNTRLMGLNNVELITDRPLDVNLKEMREIKRRYPGHALIA----SLMVETK 110 Query: 153 DDYLICMEKIYA-YAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKY 211 D++ + K A + +N P+ G+ G A+ + ++ A+ Sbjct: 111 DEWREIIRKAEDTGADGLELNFGCPH--GMCERGMGSAVGNEPAVLQEIARW--AVEFAT 166 Query: 212 VPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTL--------DRSLVQGMKNCDQT 263 P+ VK+ P++ + +++ ++++R GV NT + + Sbjct: 167 TPVIVKLTPNVGD--ILEPGEAVLRSGAHGVSLINTVKSLMGVDLERMVPLPRVGGASTN 224 Query: 264 GGLSGRPLQLKSTEIIRRLSLELN-GRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFI 322 GG G ++ + ++ +L+ GRLPI G+GGI + A E IA GA+ VQ+ + + Sbjct: 225 GGYCGPAVKPIALHLLSQLARHPGVGRLPISGIGGISNSRDAAEFIALGATSVQVCTAVM 284 Query: 323 FKGPPLIKEIVTHI 336 G +++E++ + Sbjct: 285 HYGYRIVEEMIEGL 298 >UniRef50_A0CDX9 Chromosome undetermined scaffold_17, whole genome shotgun sequence n=1 Tax=Paramecium tetraurelia RepID=A0CDX9_PARTE Length = 997 Score = 179 bits (454), Expect = 1e-43, Method: Composition-based stats. Identities = 62/299 (20%), Positives = 101/299 (33%), Gaps = 28/299 (9%) Query: 41 KVPAKPVNCMGLTFKNPLGLAAGLDKDGE-CIDALGAMGFGSIEIGT-VTPRPQPGNDKP 98 +N +G+ F NP GLA+ I G+G + T V + N P Sbjct: 541 DNIDLSINILGVNFLNPFGLASAPPTTSYPMIKRAFQEGWGFAVVKTFVLDKDAITNVSP 600 Query: 99 RLFR-----LVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKD 153 R+++ L G N + +E K + + IG +E Sbjct: 601 RIYKSTTDPLKQDPGYANIELISEKSAKYWLEGSKAIKKEFPNHVLIGSIMCQHIE---Q 657 Query: 154 DYLICMEKIYAYA--GYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKY 211 D+ K + +N+S P+ G+ L G A + +K+ + Sbjct: 658 DWRELTRKCKNEGQFDMLELNLSCPH--GMTELGMGRACGENPAIVKDICQWV--TSEID 713 Query: 212 VPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQ---------GMKNCDQ 262 +P+ VKI P+ + +A + V TNT G +N Sbjct: 714 IPVIVKITPNYPDS--ADIAQAAKEGGAKAVTLTNTFPTLMDPDPLGTPWPAVGEENNVT 771 Query: 263 TGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGF 321 GG G L+ + ++ + + I G GGI A + GAS QI S Sbjct: 772 YGGGCGSMLRPIALRKTSEVAKAI-PDIAIFGSGGIIQGDHALSFLRYGASAFQICSAV 829 >UniRef50_B3E2T4 Dihydroorotate dehydrogenase family protein n=1 Tax=Geobacter lovleyi SZ RepID=B3E2T4_GEOLS Length = 398 Score = 179 bits (453), Expect = 2e-43, Method: Composition-based stats. Identities = 54/310 (17%), Positives = 101/310 (32%), Gaps = 26/310 (8%) Query: 42 VPAKPVNCMGLTFKNPLGLAAGLDK-DGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRL 100 +G+ F+NP LA+ + + G+G I T+ P N R Sbjct: 2 PVVLDSTYLGVVFRNPFVLASAPPTATADMVRRAFEAGWGGAVIKTLIREP-VHNLPNRF 60 Query: 101 FRLVDAE---GLINRMGFNNLGVDNLVENVKKAH---YDGVLGINIGKNKDTPVEQGKDD 154 + G N + D ++ D + +I ++P E Sbjct: 61 AAIRHGNRITGFENLELLSEQAPDEWYRAIRCIKADFPDCPIIGSIMGAANSPDEWH--- 117 Query: 155 YLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPI 214 + + A A + +N S P+ G G A+ + +P+ Sbjct: 118 -SLALGCQDAGADLLELNFSCPH--GYPERGRGAAIGQNPDYAAQITRWVTDCKEITIPV 174 Query: 215 AVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQ--------GMKNCDQTGGL 266 K+ + + +A+ L G A NT + GG Sbjct: 175 IPKLTAAV--ANIQNIAEELALAGAHGFCAINTIPSFFGFDLRTLRPKPDIGGKTSYGGY 232 Query: 267 SGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGP 326 SG ++ + + L + LP++ GGI + A E + GA +VQ+ + + G Sbjct: 233 SGPGIKPIALRAVSELCQ--SPGLPVMASGGIANGFDAVEFMLLGAPVVQMATEVMLHGF 290 Query: 327 PLIKEIVTHI 336 +I + + Sbjct: 291 GIIDRMQQEL 300 >UniRef50_A0Z3E6 Dihydroorotate dehydrogenase/oxidoreductase, FAD-binding protein n=5 Tax=unclassified Gammaproteobacteria RepID=A0Z3E6_9GAMM Length = 551 Score = 176 bits (446), Expect = 1e-42, Method: Composition-based stats. Identities = 53/286 (18%), Positives = 109/286 (38%), Gaps = 30/286 (10%) Query: 45 KPVNCMGLTFKNPLGLAAGLDKDGECIDAL---GAMGFGSIEIGTVTPRPQPGNDKPRLF 101 P + +G T + +G+ I G I ++ P+ G +P Sbjct: 1 MPFSFLGKTLSGGFTVPSGIVTTAPSIIQRVIRDMPEIGVITTKSIGLEPRLGYREPVYS 60 Query: 102 RLVDAEGLINRMGFNNLGVDNLVENV--KKAHYDGVLGINIGKNKDTPVEQGKDDYLICM 159 + +N +G N G + ++ + D L ++I ++++ Sbjct: 61 QFA-PGCFVNAVGLTNPGAHASLASLGQLRVPEDRFLLVSIFG-------GSVEEFVAVA 112 Query: 160 EKIYAYAGYIAINISSPNTPG--LRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVK 217 + + A +N+S P+ G + Q + + +++ A+K P+ K Sbjct: 113 KILEPVADGFELNLSCPHASGYGMAMGQDPKIVHEIIAAVKQVV---------SKPVIPK 163 Query: 218 IAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNC--DQTGGLSGRPLQLKS 275 + P+++ + ++ + + DG+ A NT + + GG+SG+ + + Sbjct: 164 LTPNVT--NIAEIGQAALDAGADGLCAINTVGPGYTESHGEAVLSNGVGGMSGKGVLPTA 221 Query: 276 TEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGF 321 + IR L + PIIG GG+ S AGA++V I S Sbjct: 222 LKCIRELRAITDK--PIIGCGGLSSAADVNAAKHAGATIVGIGSAL 265 >UniRef50_C7M0V6 Dihydroorotate dehydrogenase family protein n=1 Tax=Acidimicrobium ferrooxidans DSM 10331 RepID=C7M0V6_ACIFD Length = 309 Score = 175 bits (445), Expect = 1e-42, Method: Composition-based stats. Identities = 74/300 (24%), Positives = 123/300 (41%), Gaps = 22/300 (7%) Query: 42 VPAKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMG-FGSIEIGTVTPRPQPGNDKPRL 100 + V L NP+ AAG G + A A+ G+ + ++T GN PRL Sbjct: 1 MADLSVARGRLVLANPILTAAGCGGYGTELAAAVALERLGAHVVKSLTTVATEGNPAPRL 60 Query: 101 FRLVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICME 160 G++N +G G+D + + D + + + P + G + + Sbjct: 61 A--PVPGGMVNSVGLAGPGIDRWLAETWPSLADARIPVALSVWGRQPRDYG--ETVRRAA 116 Query: 161 KIYAYAGYIAINISSPNTPGLRTL--QYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKI 218 +I YI +N+S PN R L A ++ A++++ PI VK+ Sbjct: 117 RIAPSLVYIELNLSCPNLEADRALFAHDPNATARVVGAVRDEVAT---------PILVKL 167 Query: 219 APDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQT--GGLSGRPLQLKST 276 + + ++ VA + V DG++A NT + G + GGLSGR +Q + Sbjct: 168 SANTD--RIVDVAHAAVAAGADGLVAINTLFAQWYDDGREALGTARGGGLSGRAVQPIAL 225 Query: 277 EIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + L L +PIIGVGG+ + + AGA VQI + F P ++ I Sbjct: 226 RAVADLRAAL-PTVPIIGVGGVATADDVERFVRAGADAVQIGTAL-FVDPRRPVLVLAEI 283 >UniRef50_B0EHW2 Dihydropyrimidine dehydrogenase, putative n=2 Tax=Entamoeba RepID=B0EHW2_ENTDI Length = 901 Score = 175 bits (443), Expect = 3e-42, Method: Composition-based stats. Identities = 61/351 (17%), Positives = 126/351 (35%), Gaps = 36/351 (10%) Query: 16 ERAHEFTFQQLRRITGTPFEALVRQKVP----AKPVNCMGLTFKNPLGLAAGL-DKDGEC 70 E H+ + + + P V G+ ++NP G+++ + Sbjct: 405 EAVHDAEVVVASIAKELGVDKIPKFHTPVDDVDISVTVDGIKYENPFGISSAPVSGTYDH 464 Query: 71 IDALGAMGFGSIEIGT--VTPRPQPGNDKPRLFRLV---DAEGLINRMGFNNLGVDNLVE 125 + GFG T + Q N R+ ++ ++ N + + +E Sbjct: 465 LKRCFQAGFGFALTKTYPLEKDIQKNNHI-RIVKVYDSQESTSYNNIVMISEHSHHYWLE 523 Query: 126 NVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPN-------- 177 ++KK + + I E+ A + +N S PN Sbjct: 524 SIKKLKAEFPNKVVIASIMCMDNADDWHLLAKLSEEAG--ADALELNFSCPNECHGNDGN 581 Query: 178 ---TPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSL 234 G A+ ++ ++ + ++P+ K+ P++ + ++A + Sbjct: 582 EGGCEGGFKSHNAMAMAIGVSPAAIERCTRYVVESVHIPVYPKLTPNV--GNIEELAAAA 639 Query: 235 VRHNIDGVIATNTTLDRSLVQ---------GMKNCDQTGGLSGRPLQLKSTEIIRRL-SL 284 +R GV NT S + G++ +GGLSG ++ + I ++ Sbjct: 640 MRGGASGVSTINTVFGISEITLSGHPWPQVGVERNTISGGLSGDLVRPIAIRQIAQVLRH 699 Query: 285 ELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTH 335 N R ++G+GG+ S A + I GAS+VQ+ S ++ EI++ Sbjct: 700 NENVRGHLLGIGGVRSAETAMQLIYTGASVVQMCSSVQKWSYDIVDEIISG 750 >UniRef50_B0PGY1 Putative uncharacterized protein n=1 Tax=Anaerotruncus colihominis DSM 17241 RepID=B0PGY1_9FIRM Length = 371 Score = 174 bits (442), Expect = 4e-42, Method: Composition-based stats. Identities = 62/300 (20%), Positives = 115/300 (38%), Gaps = 30/300 (10%) Query: 44 AKPVNCMGLTFKNPLGLAAGL-DKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFR 102 + V +G+T KNP+ +AAG D I G ++ T+T R Sbjct: 2 SLSVQFLGMTLKNPVIVAAGPWSCDAAAIQKSIDAGAAAVVTETITLEAST----RVCPR 57 Query: 103 LVDAEGLI-NRMGFNNLGVDNLVENVKKA-HYDGVLGINIGKNKDTPVEQGKDDYLICME 160 L G + N M ++ + ++ + +K+ D +L ++ ++ Sbjct: 58 LYQHGGSLFNTMLYSTIDLEQWEQEIKRIDKRDSILICSVWGATESETAYIAKKVERL-- 115 Query: 161 KIYAYAGYIAINISSP-NTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIA 219 A I ++IS+P T R + E + + A+ + +P+ VK++ Sbjct: 116 ----GADAIELSISAPIGTRSTRFGRSQEQIGGYVRAVVEAVD---------LPVMVKLS 162 Query: 220 PDLSEEELIQVADSLVRHNIDGVIATNTT---LDRSLVQGMKNCDQTGGLSGRPLQLKST 276 D S + ++ + + A ++ + GM GG SG L+ + Sbjct: 163 YDASAN--VAFVHAVEQAGAQAISAIDSLKGLAGVDIEHGMPLMPTCGGYSGANLRPVAL 220 Query: 277 EIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 L+ R I G+GGI+S E + GA+ VQ+ S + G I IV+ + Sbjct: 221 ATTATLAQLT--RCEICGIGGIESYEHVLEYVMLGANAVQLASTVLLAGYERITRIVSDL 278 >UniRef50_B7G610 Predicted protein n=2 Tax=Bacillariophyta RepID=B7G610_PHATR Length = 387 Score = 174 bits (441), Expect = 5e-42, Method: Composition-based stats. Identities = 64/309 (20%), Positives = 113/309 (36%), Gaps = 25/309 (8%) Query: 44 AKPVNCMGLTFKNPLGLAAGL-DKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFR 102 G+ K + A+G + + G++ + T + Q GN +PR + Sbjct: 4 ELATTVAGILLKTCVYNASGPRSGTSTALSKVAQSASGAVLAKSATVQKQSGNPQPRTWH 63 Query: 103 LVDAEGLINRMGFNNLGVDNLVENVK------KAHYDGVLGINIGKNKDTPVEQGKDDYL 156 D N G N G+D ++ A D +++ + Sbjct: 64 HPDYIASFNSEGLPNNGIDYYIDATTIDDAMKDADDDKPYFVSLSGKSLHDNMEMLHKIA 123 Query: 157 ICMEKIYAYAGYIAINISSPNTPGLRTLQYG-EALDDLLTAIKNKQNDLQAMHHKYVPIA 215 K I +N++ PN G + Y + +D +L + + L P+ Sbjct: 124 SAPTK--NRISAIELNLACPNVIGKPIIAYDVDQMDSILEQVSQLTDSL-------PPLG 174 Query: 216 VKIAPDLSEEELIQVADSLVRHN--IDGVIATNTTLDRSLVQGMKNCD------QTGGLS 267 VK+ P L + Q A L RH + V + NT + V + GLS Sbjct: 175 VKLPPYLDFQHFQQAASVLNRHKKLVKYVASINTLGNALAVDVVSEAPCISSNSGFAGLS 234 Query: 268 GRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPP 327 G + + +R+L L+ + ++GVGG+ S + AGA+ VQ+ + +GP Sbjct: 235 GPAVHYTALANVRKLRELLDEDIDVVGVGGVRSGKDVFAMLLAGATAVQVGTCHWIEGPS 294 Query: 328 LIKEIVTHI 336 IV + Sbjct: 295 CFDRIVDEL 303 >UniRef50_A8MCA1 Dihydroorotate oxidase n=1 Tax=Caldivirga maquilingensis IC-167 RepID=A8MCA1_CALMQ Length = 322 Score = 174 bits (440), Expect = 6e-42, Method: Composition-based stats. Identities = 77/342 (22%), Positives = 143/342 (41%), Gaps = 43/342 (12%) Query: 8 KALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKP--VNCMGLTFKNPLGLAAGLD 65 K L L P+ H+ T LR + + A P + + +P+G+ AG+D Sbjct: 5 KLLGYLPPDLTHDVTHLILRTYPVKVLIGTLTRLTGALPYRLRLLNRVIDSPIGIGAGID 64 Query: 66 KDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVE 125 KDG I + + G +G+VT +P+ GN KPR+ R + ++N MG + GVD ++ Sbjct: 65 KDGLLISLMSRLPIGFHIVGSVTLKPRRGNPKPRMRRYPGLDAMVNAMGLPSRGVD-FLK 123 Query: 126 NVK-----KAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAY---AGYIAINISSPN 177 + + +LG+++ +T ++ + ++ + Y +I IN+SSP Sbjct: 124 GILNNECVRWPRSKLLGVSVAGFSET-------EFKLLLDSLTPYMDCVDFIEINVSSPT 176 Query: 178 TPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRH 237 G + L++LL ++K + +K+ S + +++ ++ H Sbjct: 177 YGG--SWTEPHRLNELLNSLKGYDK-----------LVIKLPLLSSINDEVKLIKLIINH 223 Query: 238 NIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSL---ELNGRLPIIG 294 N G+ NT GGLSG+PL +I+ Sbjct: 224 NPFGLTIANTLS-----IKADLPMGYGGLSGKPLLGIVINLIKLTRRIGYGGLIIGLGGF 278 Query: 295 VGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + GI + I A A L+ + +GF +GP ++ I+ + Sbjct: 279 MRGI----DIIKGIKAEADLIGLVTGFAMEGPLVVYRIINEL 316 >UniRef50_C4IB41 Dihydroorotate dehydrogenase family protein n=4 Tax=Clostridiales RepID=C4IB41_CLOBU Length = 362 Score = 173 bits (439), Expect = 8e-42, Method: Composition-based stats. Identities = 60/303 (19%), Positives = 119/303 (39%), Gaps = 41/303 (13%) Query: 45 KPVNCMGLTFKNPLGLAAGLD-KDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRL 103 + +NPL A+G D + + AL G G++ T++ + +P + Sbjct: 3 LNTTIGKIKLENPLMPASGPLVGDKDKMSALNEFGVGAMVTKTISSKKAE-VVRPCI--Y 59 Query: 104 VDAEGLINRMGFNNLGVDNLVEN----VKKAHYDGVLGINIGKNKDTPVEQGKDDYLICM 159 ++N ++ + ++ +KK D L I++G K +D + Sbjct: 60 GGKNFIMNAELWSEYAPEVWIDEFLPSIKKELKDKPLIISVGYTK--------EDMEFLI 111 Query: 160 EKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIA 219 K+ +A I+ + L+ IK ++ K P+ +K++ Sbjct: 112 PKLDVFADAFEISTH--------------YVGKDLSNIKETLKTIRRFTQK--PVFMKMS 155 Query: 220 PDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTG------GLSGRPLQL 273 P + + I A ++ + G++A N+ + K G SG ++ Sbjct: 156 PHIPDP--IGFAKMVIENKGSGIVAINSLGPTMNIDIDKRSVLIGNKEGEVWTSGPAIKP 213 Query: 274 KSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIV 333 + +I ++ + IIGVGGI S E + AGAS VQ+ S + KG L ++++ Sbjct: 214 MALALIHKIKKAV-PECEIIGVGGISSADDIIEFLLAGASAVQMLSAAMLKGKDLYEKLI 272 Query: 334 THI 336 + Sbjct: 273 EEL 275 >UniRef50_C0ZGG5 Hypothetical membrane protein n=1 Tax=Brevibacillus brevis NBRC 100599 RepID=C0ZGG5_BREBN Length = 631 Score = 172 bits (437), Expect = 1e-41, Method: Composition-based stats. Identities = 71/335 (21%), Positives = 125/335 (37%), Gaps = 34/335 (10%) Query: 13 LDPERAHEFTFQQLRRITGTPFEALV------RQKVPAKPVNCMGLTFKNPLGLAAGLDK 66 + PERA T + + + P + + +TF P+GL AGLD Sbjct: 1 MPPERARSITLKSIGTLAKIPGGPSIIEWMGHMEPPSQLSKTMGPVTFPTPVGLGAGLDT 60 Query: 67 DGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVEN 126 + I AL GFG +E+G V+ P + + R + A + N G+ +L+ Sbjct: 61 ECIAIQALSKFGFGFLELGPVSKEPIVSHGT--VQRDITAMNIHYSGHLVNNGIYSLLRR 118 Query: 127 VK-KAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAI----NISSPNTPGL 181 + A +G+ + +T + + ++ + K+ + I N+ P Sbjct: 119 LTGSAGIKIPIGVRLACQPETSLREATEELQELIGKLEHICSFFTIDTRANLGQPE---W 175 Query: 182 RTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDG 241 + E L +P+ + I P LSE E + + S ++G Sbjct: 176 SHTAWKEHFSCL-------------RSQTDLPLLLAIPPSLSETEALPILTSAKEAGLNG 222 Query: 242 VIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSV 301 ++ + TG S ++ + + + IIG GG+ Sbjct: 223 LVVAGGIIQEDSSCANTFVYTTGRSS----HKQAVKFVSWTREQW-PDALIIGSGGVLEP 277 Query: 302 IAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 A +AAGA VQ++SG ++ GP L K I I Sbjct: 278 QDALTFLAAGADFVQLHSGLVYSGPGLPKRINEAI 312 >UniRef50_C9XJU2 Dihydroorotate dehydrogenase, catalytic subunit n=5 Tax=Clostridium difficile RepID=C9XJU2_CLODC Length = 361 Score = 172 bits (435), Expect = 2e-41, Method: Composition-based stats. Identities = 65/297 (21%), Positives = 116/297 (39%), Gaps = 41/297 (13%) Query: 48 NCMGLTFKNPLGLAAGLDKD-GECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDA 106 N +G K+PL + +G L G G++ T+ + + N P + R A Sbjct: 3 NFLGKELKSPLIIGSGPLTYSAAGCKILSDAGAGAVVTKTIR-KERAINPAPHMVR-NTA 60 Query: 107 EGLINRMGFNNLGVDNLVE-NVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIY-A 164 L+N + + + ++ + + DG + I V ++ +EK+ A Sbjct: 61 NALLNNEKWTDFEPEQWIDFEIPQMKRDGTVCI-------ASVGHTIEESSELVEKVANA 113 Query: 165 YAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSE 224 A +I + DL+ +K+ + + +P+ VK+ P + Sbjct: 114 GADFIEL--------------VSYDYRDLIPMLKDAKERV------NIPVIVKLPPMID- 152 Query: 225 EELIQVADSLVRHNIDGVIATNTTL---DRSLVQGMKN--CDQTGGLSGRPLQLKSTEII 279 E+ A L D + A ++ + G + G LSG ++ + + I Sbjct: 153 -EIGDFAKKLEEAGADAITACDSVGPAFRIDIETGQPLLGGNGIGYLSGETIKPITLQRI 211 Query: 280 RRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + ++N PIIG+GG S A E I AGA V I S I KG +I +I + Sbjct: 212 YEIKKQVNI--PIIGLGGCVSGDDALEMIMAGADFVGICSVVILKGAQVISKIHDDL 266 >UniRef50_UPI0001791DE1 PREDICTED: similar to dihydropyrimidine dehydrogenase n=1 Tax=Acyrthosiphon pisum RepID=UPI0001791DE1 Length = 1286 Score = 172 bits (435), Expect = 2e-41, Method: Composition-based stats. Identities = 62/356 (17%), Positives = 107/356 (30%), Gaps = 63/356 (17%) Query: 41 KVPAKPVNCMGLTFKNPLGLAAGLDKD-GECIDALGAMGFGSIEIGTVTPRPQ-PGNDKP 98 V GL F NP GLA+ I G+ T N P Sbjct: 681 DDVDLSVRMCGLRFMNPFGLASAPPTTSAAMIRRAFQAGWAFAVTKTFGLDKDLVTNVSP 740 Query: 99 RLF-------------------------RLVDAEGLINRMGFNNLGVDNLVENVKKAHYD 133 R+ V +N + + ++++ D Sbjct: 741 RIVGLGGHGVGVGSAASGIGPGTLGAGDSDVARNAFLNIELISEKTAAYWLRSIRELKRD 800 Query: 134 GVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPG-----LRTLQYGE 188 I I +E A A + +N+S P+ G L Q Sbjct: 801 FPQHILIASIMCAYIENDWTSLARLA--CDAGADALELNLSCPHGMGESGMGLACGQDPV 858 Query: 189 ALDDLLTAIKNK--QNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATN 246 ++++ +K + VP+ VKI P++++ + A + DGV A N Sbjct: 859 LVENISRWVKRVAVRPASDGGTPTAVPVFVKITPNVTDVVAVARAAVRL-GGADGVTAVN 917 Query: 247 TT----------------LDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRL 290 T GG+SG ++ + LS L Sbjct: 918 TVSALGPLDVTGNGGRPWPGVGRTTAETPRTTYGGMSGTAVRPMGLRAVSALSRALGPDA 977 Query: 291 P----------IIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 I+ GG+DS A + + GA +VQ+ S + ++++ +T + Sbjct: 978 TAGGDGGPPVQIMATGGVDSAAATLQYLYCGAKVVQVCSAVQNQDFTIVQDYITGL 1033 >UniRef50_UPI0001968A99 hypothetical protein BACCELL_01888 n=1 Tax=Bacteroides cellulosilyticus DSM 14838 RepID=UPI0001968A99 Length = 494 Score = 171 bits (434), Expect = 3e-41, Method: Composition-based stats. Identities = 55/313 (17%), Positives = 106/313 (33%), Gaps = 34/313 (10%) Query: 43 PAKPVNCMGLTFKNPLGLAAGLDKDG-ECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLF 101 VN G+ +NP LA+ E G+ + T++ Q PR Sbjct: 100 AELSVNFCGIRCENPFFLASSPVASSFEMCCHAFDAGWAGVSYKTISFY-QSREVSPRFD 158 Query: 102 RLVDA-----EGLINRMGFNNLGVDN---LVENVKKAHYDGVLGINIGKNKDTPVEQGKD 153 L G N + + ++ +K+ + + V+ +I + D Sbjct: 159 ALPGEHPFSFCGFKNLEQLSPHSAEENFEIIRRLKERYPEKVIIASIMG-------RNCD 211 Query: 154 DYLICMEKIYA-YAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYV 212 ++ + A I N S P DL+ + Sbjct: 212 EWTVLARMAEEAGADLIECNFSCPQMAKQGLGSDIGQDQDLIALYTRATRK-----GSRL 266 Query: 213 PIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDR--------SLVQGMKNCDQTG 264 PI K+ P++ EL + + + + + + A NT S + G Sbjct: 267 PIIAKMTPNIGNMELPAM--TAIANGANSLAAINTVKSITRINTENFSSYPDIGGQSAVG 324 Query: 265 GLSGRPLQLKSTEIIRRLSLELN-GRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIF 323 G SG+ ++ + IR L+ +P+ G+GGI + A + I G + +Q+ + + Sbjct: 325 GYSGQAVKPIALRFIRDLASYPPLKGIPLFGIGGITTWQDALDFILLGCTALQVCTSVME 384 Query: 324 KGPPLIKEIVTHI 336 G +I + + Sbjct: 385 YGYRIIDHLKEGL 397 >UniRef50_Q1AVZ1 Dihydroorotate oxidase B, catalytic subunit n=1 Tax=Rubrobacter xylanophilus DSM 9941 RepID=Q1AVZ1_RUBXD Length = 304 Score = 171 bits (434), Expect = 3e-41, Method: Composition-based stats. Identities = 65/298 (21%), Positives = 122/298 (40%), Gaps = 32/298 (10%) Query: 43 PAKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFR 102 P V G+ PL A+G E + + +G++ TVT RP+ GN PR+ Sbjct: 4 PELSVELCGVRLATPLIPASGTLA-PEALGEAAGV-YGAVLPKTVTLRPRQGNPPPRVAE 61 Query: 103 LVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKI 162 G++N +G N GV+ + + + +++ + +++ + ++ Sbjct: 62 --SPAGMVNSIGLQNPGVEEFLRALGAWEVGVPVFVSVAG-------ETVEEFALLCGRV 112 Query: 163 YA--YAGYIAINISSPNTP--GLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKI 218 A A I +N+S PN G A+++++ A + VP+ K+ Sbjct: 113 AADGRAAAIELNLSCPNVERGGQVFCAGPSAVEEVVAACRRA--------APDVPLLAKL 164 Query: 219 APDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEI 278 A E ++Q A + DG+ NT ++ + GGLSG ++ + Sbjct: 165 AL----EGVVQNALAAEAAGADGLTVMNTVPALAVDARARRVLLRGGLSGPAIKPLALRA 220 Query: 279 IRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + ++ +P++G GG+ S E + AGA VQ+ S + P EI+ Sbjct: 221 VYDVASA--AEIPVVGCGGVCSGADVAEFMLAGARAVQVGSAGFVRDP---AEILAEF 273 >UniRef50_B8D2W4 Dihydroorotate dehydrogenase family protein n=1 Tax=Desulfurococcus kamchatkensis 1221n RepID=B8D2W4_DESK1 Length = 407 Score = 168 bits (425), Expect = 3e-40, Method: Composition-based stats. Identities = 62/315 (19%), Positives = 117/315 (37%), Gaps = 27/315 (8%) Query: 42 VPAKPVNCMGLTFKNPLGLAAGL-DKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRL 100 + V GL +NP+ AA +D + + L G G++ T++ +P +P + Sbjct: 5 MADLSVELAGLKLRNPIMNAACPVSRDADAMRMLIDNGVGAVVAKTISVKP-AIVPRPSM 63 Query: 101 FRLVDAEGLINRMGFNN--LGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKD-DYLI 157 GL+ G + H +N D P E + +Y + Sbjct: 64 A--AVDRGLVRAHLLKTLKPGDVRITPVDSGNHRFIYAVLNAELWSDIPAEHYLEREYPL 121 Query: 158 CMEKIYAYAGYI---------AINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMH 208 +++ P + + + +A+ Sbjct: 122 VKSYCEEKGAVFIASIGYTPEELSLLGPKVEKAGVQAIEFSTHYIGRDYRPVIEAAKALR 181 Query: 209 HK-YVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTL---DRSLVQGMKNCDQ-- 262 +PI K++P + ++ L + +DG++ATNT + G+ Sbjct: 182 ESVDIPIFPKLSPF--TPNIPELVKELEKVGVDGIVATNTIGPALHIDVETGLPIVGGPY 239 Query: 263 -TGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGF 321 G +SG L+ + ++ +++ LN +LP+IGVGGI + E AGAS VQI + Sbjct: 240 GYGWMSGPALKPLALAVVSQVA--LNTKLPVIGVGGISRGVDVIEYFMAGASAVQICTAA 297 Query: 322 IFKGPPLIKEIVTHI 336 + +GP I+ + Sbjct: 298 LIEGPQAFARIIREV 312 >UniRef50_A4FBL7 Dihydroorotate dehydrogenase n=1 Tax=Saccharopolyspora erythraea NRRL 2338 RepID=A4FBL7_SACEN Length = 338 Score = 167 bits (422), Expect = 7e-40, Method: Composition-based stats. Identities = 66/324 (20%), Positives = 116/324 (35%), Gaps = 60/324 (18%) Query: 36 ALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMG------------FGSIE 83 LVR + A V + +N L ++ L G L G FG++ Sbjct: 8 RLVRDEPLAPAVRLGDIHLRNRLVTSSSLLGYGVANAKLIPYGMSPISQFVPLERFGAVT 67 Query: 84 IGTVTPRPQPGNDKPR----LFRLVD------------AEGLINRMGFNNLGVDNLVENV 127 T+T P+ G+ R L L G +N G+ N+G+D + + Sbjct: 68 TRTLTVEPREGHFTTRDQWPLHELPALLKRYGQALRQVDGGWLNAFGWCNVGLDAYLRDY 127 Query: 128 KKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYA-----GYIAINISSPNTPGLR 182 I++G ++++ ++KI + N+S N Sbjct: 128 YPRTRGQNTIISVGGF-------SAEEFVTLIDKINDAVPAGDIAAVEFNVSCHNV---- 176 Query: 183 TLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGV 242 + ++ ++ + A+ P+ +K++PD + A +H + + Sbjct: 177 ----NFDFNAIIESVLAE-----AVPRSAHPVILKLSPDYD---YLAHARLAAKHGVSAL 224 Query: 243 IATNTTLDRSLVQGMKN---CDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGID 299 A NT L ++ GGLSGR ++ ++ L +LPII GGI Sbjct: 225 TAINTVKGLRLDPETGQPLLKNRFGGLSGRAIKPIGLRVVAELRDA-GVKLPIIATGGIR 283 Query: 300 SVIAAREKIAAGASLVQIYSGFIF 323 + RE AGA V + S F Sbjct: 284 TFDDCREYFWAGADAVSLGSATWF 307 >UniRef50_Q7N0H1 Similar to dihydroorotate dehydrogenase PyrD n=1 Tax=Photorhabdus luminescens subsp. laumondii RepID=Q7N0H1_PHOLL Length = 289 Score = 166 bits (421), Expect = 1e-39, Method: Composition-based stats. Identities = 53/293 (18%), Positives = 110/293 (37%), Gaps = 29/293 (9%) Query: 48 NCMGLTFKNPLGLAAGLDKD-GECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDA 106 + +G+ KNP+ + +GL D + I A G G++ T+ PR + + + + Sbjct: 11 DVLGMKIKNPIIVGSGLLSDQAKNIRQFIAHGAGAVVTKTIYPRSEKLHTEKTYLF---S 67 Query: 107 EGLINRMGFNNLGVDNLVENVKKAHYDG-VLGINIGKNKDTPVEQGKDDYLICMEKIYAY 165 G++N ++ V+ + +++ + + ++I + + +I A Sbjct: 68 TGMLNNTTYSKKTVEYWLTLLREFKEEQLPVIVSI-------HAESPEALASLAVRISAV 120 Query: 166 AGY-IAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSE 224 + + IS L + +D + N ++ + P AVK++ Sbjct: 121 TDAPLELGISC--------LHADDFTEDTPERVFNYTKVVKERTNT--PFAVKLSLG--- 167 Query: 225 EELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTG--GLSGRPLQLKSTEIIRRL 282 + L + V D + ++T + G G SG ++ I L Sbjct: 168 DNLYGRVQAAVEGGADAITLSDTISGIAFDTANGEALLNGVCGYSGPGIKPMVLAAIYNL 227 Query: 283 SLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTH 335 +PI+G GG+ E + AGA+ VQ+Y+ ++ IV Sbjct: 228 RKR-GVTIPILGSGGVQDGNDVHEYLLAGANTVQVYTALHRHMYKTLQRIVHE 279 >UniRef50_Q972L2 350aa long hypothetical dihydroorotate dehydrogenase n=1 Tax=Sulfolobus tokodaii RepID=Q972L2_SULTO Length = 350 Score = 165 bits (419), Expect = 1e-39, Method: Composition-based stats. Identities = 52/312 (16%), Positives = 110/312 (35%), Gaps = 31/312 (9%) Query: 42 VPAKPVNCMGLTFKNPLGLAAGLD-KDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRL 100 + V G+TF NP + +G + I + G+G + + T+ + +P Sbjct: 1 MIDLSVTFQGITFPNPFLVGSGPTTGNPPKIISAIRAGWGGVVVKTIGDSIVRKSVRPMY 60 Query: 101 FRLVDAEGLI---NRMGFNNLGVDNLVENVKKAHYDG----VLGINIGKNKDTPVEQGKD 153 + +I N ++ + ++ + + ++I D Sbjct: 61 ATIRRNREIIAFENLELITEDPLEVWDKYLRVIKSEIGKSAPIIVSIMGGPDYS------ 114 Query: 154 DYLICMEKIYA-YAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYV 212 +++ A + +N P+ G + G + ++ ++ + + Sbjct: 115 EWIRLARWAEDRGADMLELNFGCPH--GEPEKRTGAFIGQHADLVQEYTKEVVSSVG--I 170 Query: 213 PIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKN--------CDQTG 264 P+ K+ P++++ + + A + V A NT V + G Sbjct: 171 PVIAKLTPNITD--IRETAKAAENAGAKAVTAINTVNGVIAVDIERAQPLPDINGYSGYG 228 Query: 265 GLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFK 324 G+SG ++ + ++ + + I GVGGI A E I GA+ VQ + I K Sbjct: 229 GISGPAVKPIGLAAVSKIYTSTSLQ--ISGVGGIFDWRDAVEYIMMGATTVQSVTYTILK 286 Query: 325 GPPLIKEIVTHI 336 G I E + Sbjct: 287 GFEFINEWKKEL 298 >UniRef50_D1B5N0 Dihydroorotate dehydrogenase family protein n=1 Tax=Thermanaerovibrio acidaminovorans DSM 6589 RepID=D1B5N0_THEAS Length = 316 Score = 165 bits (419), Expect = 2e-39, Method: Composition-based stats. Identities = 67/298 (22%), Positives = 122/298 (40%), Gaps = 28/298 (9%) Query: 46 PVNCMGLTFKNPLGLAAG-LDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLV 104 V+ GL +P+ +A+G L DGE ++ G G I +T P+ GN RL Sbjct: 17 NVDLNGLGLSSPVVVASGVLPMDGEVWSSME--GVGLICTKGITLEPRAGNRGERLVE-- 72 Query: 105 DAEGLINRMGFNNLGVDNLVENVKK--AHYDGVLGINIGKNKDTPVEQGKDDYLICMEKI 162 GL+N +G N G+D +E + LG+N+ + +E + + + Sbjct: 73 TPSGLLNSIGLENPGIDRFLEAILPDLLRSRRSLGLNVAFSSLGELE----ELIGRIGDR 128 Query: 163 YAYAGYIAINISSPNTPGLRTLQ-YGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPD 221 A + +N+S PN R +GE+ + A++ + + K+ P Sbjct: 129 AASVEVLELNLSCPNVD--REGAVWGESPERTFEAVRLAR------SLWPRSVWAKLTPQ 180 Query: 222 LSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKN---CDQTGGLSGRPLQLKSTEI 278 + + A + ++ NT L + GLSG + + + Sbjct: 181 APDVAAVARAAEEAGAHC--LVVANTWLGAEVDLEAGAPVFKRVVAGLSGPAVLPLTLRL 238 Query: 279 IRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + +L +++ +P++ GGI S A + + AGAS VQ+ + F+ EI+ I Sbjct: 239 LFQLYPKVS--VPLVACGGICSPQDALKAMMAGASAVQVGTQL-FRDLGCCGEILEGI 293 >UniRef50_A8F8E8 Dihydroorotate dehydrogenase n=1 Tax=Thermotoga lettingae TMO RepID=A8F8E8_THELT Length = 386 Score = 164 bits (416), Expect = 3e-39, Method: Composition-based stats. Identities = 59/304 (19%), Positives = 110/304 (36%), Gaps = 27/304 (8%) Query: 44 AKPVNCMGLTFKNPLGLAA-GLDKDGECIDALGAMGFGSIEIGTVTPRPQ-PGNDKPRLF 101 +G+ KNP+ +A+ GL ++ + + G + ++ + PR Sbjct: 2 DLSCEYVGIKLKNPIIVASSGLAENLKNMKKAEEHGAACVVAKSLFEEKICRISPTPRFE 61 Query: 102 RLVDAEGLINRMGF------NNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDY 155 + G + F + E ++KA + + N T Y Sbjct: 62 IIERKMGKLRSQTFYSFEQASPFDAHEYFEEIRKAVNTLSIPVIPSINCVTDEGWS--QY 119 Query: 156 LICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIA 215 E A A + +N+S P+ G + + G+ + +L+ K ++ ++ +P+ Sbjct: 120 ARMAE--GAGAPALELNVSCPH--GSISFRGGDVEEKILSVAKIVRDSVK------IPLI 169 Query: 216 VKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLV---QGMKNCDQTGGLSGRPLQ 272 VK+ LS + +A L R IDGV+ N + + + G G Sbjct: 170 VKLPMQLSSP--LSMAKMLERSGIDGVVMFNRLTGLDINLEKERPVLHEGYAGHGGPWAF 227 Query: 273 LKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 I S LN + GG+ S + I AGA+ V++ S G I + Sbjct: 228 NYVLRWIAASSPHLNIS--VAASGGVGSGEDIIKYIYAGANAVEVCSLIYLSGYEAIDML 285 Query: 333 VTHI 336 + I Sbjct: 286 LEQI 289 >UniRef50_A6BB63 Dihydroorotate dehydrogenase n=1 Tax=Vibrio parahaemolyticus AQ3810 RepID=A6BB63_VIBPA Length = 181 Score = 163 bits (414), Expect = 6e-39, Method: Composition-based stats. Identities = 91/156 (58%), Positives = 132/156 (84%) Query: 181 LRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNID 240 + ++YGEALD+LL+ +K KQ++L H KYVP+A+KIAPDLS++E+ Q+ +SL+++NID Sbjct: 26 IAQMEYGEALDELLSELKAKQSELAEKHGKYVPLALKIAPDLSDDEITQICESLLKNNID 85 Query: 241 GVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDS 300 GVIATNTTLDR++V+GMK+ ++ GGLSGRP+Q +STE++R+L L +LPIIGVGGIDS Sbjct: 86 GVIATNTTLDRTVVEGMKHANEAGGLSGRPVQSRSTEVVRKLHEALGDKLPIIGVGGIDS 145 Query: 301 VIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 +AA+EK+ AGA LVQ+Y+GFI+ GP L+++IV ++ Sbjct: 146 YVAAKEKMMAGAQLVQVYTGFIYHGPGLVRDIVKNL 181 >UniRef50_Q0CXV7 Putative uncharacterized protein n=1 Tax=Aspergillus terreus NIH2624 RepID=Q0CXV7_ASPTN Length = 708 Score = 162 bits (411), Expect = 1e-38, Method: Composition-based stats. Identities = 88/350 (25%), Positives = 140/350 (40%), Gaps = 53/350 (15%) Query: 22 TFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGS 81 T + R P L+ + G T NP+G++AGLDK E D L A+G Sbjct: 92 TRASVHRYGVVPLIRLLYPDAED-AHHIFGYTISNPIGISAGLDKHAEIPDPLFALGPAI 150 Query: 82 IEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKKAHY--------- 132 +E+G TP PQ GN +PR+FRL +INR G N+ G D++ + Sbjct: 151 VEVGGTTPLPQEGNPRPRVFRLPSQRAMINRYGLNSKGADHMAALLDARVRAWAYAHGFG 210 Query: 133 -----------------------DGVLGINIGKNKDTPVEQ---GKDDYLICMEKIYAYA 166 +L + + KNK TP K DY+ C++++ YA Sbjct: 211 DHEAAKTAVLNGAAGVPPGSLQAGKLLAVQVAKNKATPDGDLEAIKRDYVYCVDRVAPYA 270 Query: 167 GYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEE 226 + +N+SSPNTPGLR LQ L +L A+ + + VK + Sbjct: 271 DIVVVNVSSPNTPGLRDLQATAPLTAILRAVVGAAKSVDRATKPV--VMVKTGGYSGPQL 328 Query: 227 LIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLEL 286 + + R+ R+L+ + G +G + + S E Sbjct: 329 FDRTVALVARY-------------RALLDQGPPSEGAGAATGAQGAEAGSAKVP--SGEA 373 Query: 287 NGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 R + GGI + AR + AGAS+ +Y+G ++ G + + + Sbjct: 374 AARKVLFASGGITNGQQARAVLDAGASVAMMYTGVVYGGVGTVTRVKQEM 423 >UniRef50_Q23YG3 Dihydroorotate dehydrogenase family protein n=1 Tax=Tetrahymena thermophila SB210 RepID=Q23YG3_TETTH Length = 1080 Score = 162 bits (411), Expect = 1e-38, Method: Composition-based stats. Identities = 60/332 (18%), Positives = 112/332 (33%), Gaps = 32/332 (9%) Query: 27 RRITGTPFEALVRQ-----KVPAKPVNCMGLTFKNPLGLAAGLDKDGE-CIDALGAMGFG 80 + P + G+ +NP GLA+ I +G+ Sbjct: 599 KHGQKVPETPELPGFYTEIDDVDISTEICGVKMENPFGLASAPPTTSYPMIARSFDIGYD 658 Query: 81 SIEIGT-VTPRPQPGNDKPRLFRLVDA----EGLINRMGFNNLGVDNLVENVKKAHYDGV 135 + T V + N PR+F++ D N + + VE K+ D Sbjct: 659 FAVVKTAVLDKDTVFNVSPRIFKVPDPLRQECSYGNIELVSEKSLKYWVEGAKQIKKDYP 718 Query: 136 LGINIGKNKDTPVEQGKDDYLICMEKIYAYA-GYIAINISSPNTPGLRTLQYGEALDDLL 194 + IG + D++ M ++ I +N+S P+ G+ G A + Sbjct: 719 NKVLIG---SLMAAYNQQDWIDIMHQVKDAPFDMIELNLSCPH--GMNEKGMGRACGEDP 773 Query: 195 TAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLV 254 +++ + + +PI VKI P+ + E+ +A + V TNT Sbjct: 774 DIVRDITSWV--TSQTKIPIIVKITPNYGQAEI--LAKAAYEGGAKAVTLTNTMPGLVDP 829 Query: 255 Q---------GMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAR 305 G++ GG +G L+ + ++ + + I GGI S Sbjct: 830 YPDGESFNGVGVEKNVAPGGSTGSILRPFAMRKCVDVAKFV-PEIDIFASGGIISGDHGI 888 Query: 306 EKIAAGASLVQIYSGFI-FKGPPLIKEIVTHI 336 + GA +QI S + ++ T + Sbjct: 889 NYLHYGAKALQICSAVQNLDAATVFYDLKTSL 920 >UniRef50_A2ELU8 Dihydroorotate dehydrogenase family protein n=3 Tax=Trichomonas vaginalis RepID=A2ELU8_TRIVA Length = 811 Score = 162 bits (411), Expect = 1e-38, Method: Composition-based stats. Identities = 70/349 (20%), Positives = 128/349 (36%), Gaps = 36/349 (10%) Query: 14 DPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAAGL-DKDGECID 72 D A L P + G+ FKNP G+++ ECI Sbjct: 334 DARTAARMIADYLGEKREIP-CFETEVDHVSLETEFCGMKFKNPSGISSAPVSGTYECIR 392 Query: 73 ALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDA-------EGLINRMGFNNLGVDNLVE 125 G G T+ P + FR+V A N + ++ Sbjct: 393 NCFKAGMGWAVTKTI--LPTKDVIRENDFRIVKADENPGPSGSFCNICMMTEHTEEYWLD 450 Query: 126 NVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPN-------T 178 +KK + + + + ++ + + + I A A + +N+S PN Sbjct: 451 TIKKLKAEFPDRVLVASIATSDSKERWQNLVKNV--IAAGADALELNLSCPNEVHGEGGC 508 Query: 179 PGLRTLQY--GEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVR 236 G + G AL ++K ++ VP VK+ P++++ I +A + + Sbjct: 509 KGGFDTENKIGMALGTHPISVKRISQYVKEAT--TVPFFVKLTPNITDP--IDIAQAALE 564 Query: 237 HNIDGVIATNTTLDRSLVQ---------GMKNCDQTGGLSGRPLQLKSTEIIRRLSLELN 287 DGV NT + G + +GGLSG ++ + I R+ + Sbjct: 565 GGADGVAMINTVSGIAKFWPDGTPLPQVGKEKYVLSGGLSGDQVRPIALRQISRVHNKF- 623 Query: 288 GRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 +PI+G+GGI S A + + AG+S+ Q+ S +++E+ + Sbjct: 624 PEMPILGIGGIGSGYTALQHLYAGSSVFQMCSAIQRYSYDIVREVNAGL 672 >UniRef50_A3DL41 Dihydroorotate dehydrogenase family protein n=1 Tax=Staphylothermus marinus F1 RepID=A3DL41_STAMF Length = 406 Score = 160 bits (406), Expect = 4e-38, Method: Composition-based stats. Identities = 66/317 (20%), Positives = 114/317 (35%), Gaps = 31/317 (9%) Query: 42 VPAKPVNCMGLTFKNPLGLAAGL-DKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRL 100 + + V GL KNPL AA +D E + AL G G++ T++ RP +P + Sbjct: 1 MVSLEVEIAGLKMKNPLMNAACPVSRDAEMMKALIDNGVGAVVAKTISVRP-AIVPRPSM 59 Query: 101 FRLVDAEGLINRMGFN--NLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKD-DYLI 157 G++ G +V + +N D P E + +Y I Sbjct: 60 G--AVDRGIVRSQILKTFGPGNVRIVNADSGNYRFIYALLNAELWSDIPAEHYFEREYPI 117 Query: 158 CMEKIYAYAGYIAINIS------------SPNTPGLRTLQYGEALDDLLTAIKNKQNDLQ 205 + I+I + + L+ Sbjct: 118 VKKYAEEKGVPFIISIGYKPEELQLLGPKCQKAGANAIEFSTHYIGKDYRPVVEAAKALR 177 Query: 206 AMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTL---DRSLVQGMKNC-- 260 + +PI K++P + ++ L + +DG++ATNT + G+ Sbjct: 178 EVV--DIPIFAKLSPF--TPNIPELVKELEKVGVDGIVATNTIGPALHIDIETGLPIVGG 233 Query: 261 -DQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYS 319 + G +SG L+ + ++ + LP+IGVGGI E AGAS VQI + Sbjct: 234 PNGYGWMSGPALKPLALAVVAEAAKNT--HLPVIGVGGISKGTDVIEYFMAGASAVQICT 291 Query: 320 GFIFKGPPLIKEIVTHI 336 + +G + + I I Sbjct: 292 AALIEGLGVFRRIEKEI 308 >UniRef50_C1TLU5 Dihydroorotate dehydrogenase family protein n=1 Tax=Dethiosulfovibrio peptidovorans DSM 11002 RepID=C1TLU5_9BACT Length = 302 Score = 159 bits (403), Expect = 1e-37, Method: Composition-based stats. Identities = 66/303 (21%), Positives = 114/303 (37%), Gaps = 37/303 (12%) Query: 42 VPAKPVNCMGLTFKNPLGLAAGL-DKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRL 100 + V L F NP+ AAG E + G G I TV+ P KP + Sbjct: 1 MADLTVKLGKLKFINPVLPAAGPNVMRLEQMLEAVERGAGGIVTKTVSREPAV-YPKPCI 59 Query: 101 FRLVDAEGLINRMGFNNLGVDNLVENVKKAHY-DGVLGINIGKNKDTPVEQGKDDYLICM 159 + GL+N +++ + +++ K L +IG +D Sbjct: 60 SKGPCD-GLLNCETWSDRPWRSYIDDYVKVKETGVPLICSIG--------YSPEDVAELG 110 Query: 160 EKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIA 219 + + A G + S Y D L + P+ +K++ Sbjct: 111 KALEAEVGPDVVEFS---------THYVGKTLDPLKRVAEALR-----GSVSCPVWMKVS 156 Query: 220 PDLSEEELIQVADSLVRHNIDGVIATNTTLDR---SLVQGMKNC---DQTGGLSGRPLQL 273 P S + ++A + + +DG +A N+ + + D G LSG + Sbjct: 157 P--STPNIPEMAKVMSDY-VDGFVAVNSVGPALDFDIDKPKPRLGTEDGHGWLSGPAITG 213 Query: 274 KSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIV 333 + + ++S + P++GVGGI + A + I AGASLV I S I +G + +I Sbjct: 214 VALYAVYQIS--HSQDKPVVGVGGIRTGEDAVKFIMAGASLVGICSEAIRRGTGIYGKIA 271 Query: 334 THI 336 + I Sbjct: 272 SEI 274 >UniRef50_P07670 Dihydroorotate dehydrogenase n=1 Tax=Dictyostelium discoideum RepID=PYRD_DICDI Length = 370 Score = 158 bits (401), Expect = 2e-37, Method: Composition-based stats. Identities = 54/340 (15%), Positives = 124/340 (36%), Gaps = 50/340 (14%) Query: 37 LVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGND 96 K P+K ++ +G +P+G+ AG + + + GF T+ G+ Sbjct: 34 RNDNKDPSKYIDFLGQKLASPIGVPAGPLLNSQWVKFALEAGFDLPTYKTIRSHEHFGHP 93 Query: 97 KPRLFRLV---------------------------DAEGLINRMGFNNLGVDNLVENVKK 129 P + L D + N G ++G + L +++ Sbjct: 94 VPNVMYLDLESEDKQFTKSDSGSTLHATQTIPTTMDQLAITNSFGMPSMGKEYLYKDIAL 153 Query: 130 AHY----DGVLGINIGKNKDTPVEQGKDDYLICME-KIYAYAGYIAINISSPN--TPGLR 182 AH + ++I + D++ + A A + +N S PN T + Sbjct: 154 AHSYLGSGQSMIVSITGTASSAH-DFLQDFVDTVRIACDAGAKMVEVNYSCPNVVTGEGQ 212 Query: 183 TLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGV 242 +A+ ++ + + ++ + K +P+ +K+ E++ ++ R + + Sbjct: 213 IYHNPDAVYEISSTL------VKELSSKNIPLIIKVGVMDDLEKMERLFQQAERAGVAAI 266 Query: 243 IATNT-----TLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLS---LELNGRLPIIG 294 NT T + + T G+ G P++ + + + S + N +L ++G Sbjct: 267 AGINTLSMKVTDKITGEPSLGASRLTSGVCGAPIRSAALDWVSTASSIIKKQNSKLKLLG 326 Query: 295 VGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVT 334 GGI + + +GA + +G ++ P + + Sbjct: 327 CGGIVKPEHFDDFLNSGADIAMSATGLMW-DPYIAMKWHN 365 >UniRef50_Q8YVR2 Alr1912 protein n=15 Tax=Bacteria RepID=Q8YVR2_ANASP Length = 343 Score = 157 bits (397), Expect = 6e-37, Method: Composition-based stats. Identities = 48/305 (15%), Positives = 103/305 (33%), Gaps = 32/305 (10%) Query: 44 AKPVNCMGLTFKNPLGL-AAGLDKDGECIDALGAMGFGSIEIGTV-----TPRPQPGNDK 97 N +GL ++PL A+ + + + I + G ++ + ++ + + Sbjct: 2 DLTTNYLGLRLRSPLVPSASPMSGEIDNILWMEDAGAAAVVLPSLFEEQLSLESYELHHH 61 Query: 98 PRLFRLVDAEGLINRMGFNNL-----GVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGK 152 E L F G + + ++K + I N + Sbjct: 62 LTYGTESFPESLTY---FPEHQDFRLGSEEYLNLIQKTKEKVKIPIIASLNGSSLDGWT- 117 Query: 153 DDYLICMEKIYAYAGYIAINISSPNT-PGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKY 211 +Y +E+ A + +N S +T P L + Q ++ ++L +K Sbjct: 118 -EYARMIEQAG--AAALELNTYSVHTDPELTSEQIEQSYINMLKVVKASVQ--------- 165 Query: 212 VPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPL 271 +P+A+K++P + + +A L D ++ N + LS Sbjct: 166 IPVAIKLSPYFT--NMANMAKRLDDAGADALVLFNRFYQPDINLETLEVQPHVLLSTPQA 223 Query: 272 QLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKE 331 I L +N + GI + + + AGA++ + S + G I+ Sbjct: 224 MRLPLRWIAILYGHINAH--LAATSGIHNGHDVLKMLMAGANITMLCSVLLRHGIDHIRC 281 Query: 332 IVTHI 336 I + Sbjct: 282 IEQEM 286 >UniRef50_A2EKA7 Dihydroorotate dehydrogenase family protein n=3 Tax=Trichomonas vaginalis RepID=A2EKA7_TRIVA Length = 365 Score = 156 bits (395), Expect = 8e-37, Method: Composition-based stats. Identities = 48/298 (16%), Positives = 101/298 (33%), Gaps = 25/298 (8%) Query: 44 AKPVNCMGLTFKNPLGLAAGLD-KDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFR 102 + G KNPL A G +D + G G + T++ +P ++ Sbjct: 2 SLKTKFAGYEVKNPLMPAPGPPVRDAKACIDCIKGGCGVMVTKTISVAAAK-VPQPNMYE 60 Query: 103 LVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKI 162 D + +N + L + +E+ + I + ++ K+ Sbjct: 61 SKDHKYFLNTELWTELTPEQWLEHEYPKIREVCNQAKI--PMICSMGYTAEEIAKMAPKV 118 Query: 163 YAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDL 222 + + ++ + + D + A P+ VK++P Sbjct: 119 APFCDGLELSTH-------YIGDDPKPMQDAIKAA--------IHGSGGKPVYVKLSPFR 163 Query: 223 SEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQ----TGGLSGRPLQLKSTEI 278 + A + + V + TL + + G +SG ++ + + Sbjct: 164 DAPIAAKAAKAAGATGLVCVNSFGPTLALDIERKGAPFMGSTSKYGWVSGPAIKPLALRV 223 Query: 279 IRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 + + E+ LP++GVGGI + A E + AGA + I + I +G + I + Sbjct: 224 VYDVCKEV--DLPVVGVGGISNGRDAIEFLMAGAQALGICTAAIVEGRDVYGSIAQEM 279 >UniRef50_A0ADR6 Putative hihydroorotate dehydrogenase n=1 Tax=Streptomyces ambofaciens ATCC 23877 RepID=A0ADR6_STRAM Length = 297 Score = 155 bits (392), Expect = 2e-36, Method: Composition-based stats. Identities = 59/292 (20%), Positives = 114/292 (39%), Gaps = 25/292 (8%) Query: 48 NCMGLTFKNPLGLAAGLDKDGE-CIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDA 106 +GL +P+ + +GL D E I L G ++ T+ P P P + RL RL Sbjct: 6 RILGLRLSSPVVVGSGLLTDQERNIRRLFDDGASAVVTKTIHPDPGPA-GEERLLRLPT- 63 Query: 107 EGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYA 166 G++N ++ V + +++ DG L + + ++P E + + + + A Sbjct: 64 -GMLNSTTYSRRPVGDWCAMLRRFADDG-LPVIASVHAESPDELA--ELADLVGQAGSPA 119 Query: 167 GYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEE 226 + + IS N G LDD + + ++ VP +VK+A E Sbjct: 120 --LELGISCLN--------EGGGLDDTPERVAAYTDAVRRRT--PVPFSVKLAAG---ER 164 Query: 227 LIQVADSLVRHNIDGVIATNTTLD--RSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSL 284 L + ++ + D + ++T G G SG ++ I L Sbjct: 165 LRERVEAALACGADAITLSDTVAGLAVDADTGEVRLGGAFGYSGAGIKPLVLAEIFGLRR 224 Query: 285 ELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 +P++ GG+++ E ++ GA VQ+Y+ + ++ I Sbjct: 225 A-GLTVPVMASGGVENGRDVAEYLSVGADAVQVYTALHREMHATLRAIRRGF 275 >UniRef50_Q47C62 Dihydroorotate dehydrogenase n=3 Tax=Proteobacteria RepID=Q47C62_DECAR Length = 336 Score = 154 bits (389), Expect = 4e-36, Method: Composition-based stats. Identities = 51/303 (16%), Positives = 105/303 (34%), Gaps = 25/303 (8%) Query: 42 VPAKPVNCMGLTFKNPLGLAA-GLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRL 100 +P +GL+ KNPL ++ L D + + L G +I + ++ +++ Sbjct: 1 MPDLSTTYLGLSLKNPLVPSSTPLSHDLDAVLHLEDAGAAAIVMHSLFEEDVRHDEQMID 60 Query: 101 FRLVDAEGLINRMGFNNLGVDN------LVENVKKAHYDGVLGINIGKNKDTPVEQGKDD 154 LV + G G D +E +++ + + N + Sbjct: 61 RFLVHPDTFGEATGHLPFGHDYQSRLDSYLEQIQRLKSRLAIPVVASLNGSSLSGWV--- 117 Query: 155 YLICMEKIYAYAGYIAIN-ISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVP 213 + E A A + +N P+ P + + LL +K +P Sbjct: 118 -ELGKEMQGAGADALELNAWYMPSDPKISCEAIEDHHVSLLQELKTVV---------SIP 167 Query: 214 IAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQL 273 +++K++P S L + G+ N + + LS L Sbjct: 168 VSMKLSPFFSS--LPHFVHQIEMAGAAGISLFNRFFQPDIDLETLSVVDRVQLSSSADTL 225 Query: 274 KSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIV 333 + I L +L + GG+ + A + + AGA + + S + +GP + E++ Sbjct: 226 LAMRWIAILRGST--KLSLAATGGVHTAEDALKMLLAGADVAHMASALLKRGPQALGEVL 283 Query: 334 THI 336 + Sbjct: 284 AAM 286 >UniRef50_B8E1W3 Dihydroorotate dehydrogenase n=3 Tax=Bacteria RepID=B8E1W3_DICTD Length = 390 Score = 153 bits (386), Expect = 1e-35, Method: Composition-based stats. Identities = 57/304 (18%), Positives = 111/304 (36%), Gaps = 27/304 (8%) Query: 44 AKPVNCMGLTFKNPLGLAA-GLDKDGECIDALGAMGFGSIEIGTVTPRPQ-PGNDKPRLF 101 + +GL KNP+ +A+ GL ++ + + G G++ + ++ + PR Sbjct: 2 DLSCSYVGLRLKNPIIIASSGLTENLKNMKKCEENGAGALVVKSLFEEEICRVSPTPRFE 61 Query: 102 RLVDAEGLINRMGF------NNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDY 155 + + G + F + + + + KA + + N T K Y Sbjct: 62 IISRSMGPLRSQTFYSFEQASPFEPEEYFKEISKALSVLSIPVIPSINCITDDGWLK--Y 119 Query: 156 LICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIA 215 E++ A + +N+S P+ Q + + +L + + +++ +PI Sbjct: 120 SKMAEEVG--APALELNVSCPHASISFRGQDVD--ETILHVARIVRENVK------IPIV 169 Query: 216 VKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSG---RPLQ 272 VK+ LS + VA +L +DGV+ N + + GG +G Sbjct: 170 VKLPMQLSSP--LAVAKALENIGVDGVVMFNRLTGLDINLDTEKPILHGGYAGHGGPWAF 227 Query: 273 LKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 I L + G + S + I GA +VQI S G +I I Sbjct: 228 NYVLRWISTSRPHLKLSIAGSGG--VGSGDDVAKYILTGADVVQICSIVYLMGYEIIPRI 285 Query: 333 VTHI 336 + + Sbjct: 286 IDGL 289 >UniRef50_B1ZTF1 Dihydroorotate dehydrogenase n=1 Tax=Opitutus terrae PB90-1 RepID=B1ZTF1_OPITP Length = 332 Score = 152 bits (383), Expect = 3e-35, Method: Composition-based stats. Identities = 58/303 (19%), Positives = 103/303 (33%), Gaps = 30/303 (9%) Query: 45 KPVNCMGLTFKNPLGL-AAGLDKDGECIDALGAMGFGSIEIGTVT-----PRPQPGNDKP 98 +GL +NPL + A+ D E L G ++ + ++ + N Sbjct: 5 LATTYLGLPLRNPLIVGASPFSDDLEAARQLQEAGAAALVMRSLFEEQIDLEQRALN--- 61 Query: 99 RLFRLVDAEGLINRMGFNNLG-----VDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKD 153 R + F G D + ++ + + I N P Sbjct: 62 RDLEALTESFAEASSFFPEYGEYQLTPDRYLRQIELLTSELDIPIIASLNGRHPGGWL-- 119 Query: 154 DYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVP 213 DY E A A I +N T + E D+L+ +++ ++ +P Sbjct: 120 DYARKFE--AAGADAIELNFYQLVTDPKVSGDEIE--DELIETLRSVVTAVR------IP 169 Query: 214 IAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQL 273 +AVK++P + L +L + G++ N T LS L Sbjct: 170 VAVKLSPFHTS--LPHFTQALRQAGAAGLVLFNRLYQPDFDVDALEVQPTLRLSDPGELL 227 Query: 274 KSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIV 333 + LS G + GG+ S + + AGA VQI S + +GP ++K ++ Sbjct: 228 LRLRWLAILSPNHLGS--LAASGGVHSGTDVAKAVLAGADAVQIVSAVLRQGPAVLKTLL 285 Query: 334 THI 336 Sbjct: 286 QDF 288 >UniRef50_A3ETM0 Dihydroorotate dehydrogenase n=3 Tax=Leptospirillum RepID=A3ETM0_9BACT Length = 368 Score = 150 bits (379), Expect = 6e-35, Method: Composition-based stats. Identities = 65/346 (18%), Positives = 112/346 (32%), Gaps = 48/346 (13%) Query: 29 ITGTPFEALVRQKVP--AKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGT 86 PF + V K ++ MG + LG+ AG + I G MGF + T Sbjct: 17 YQHGPFFSGVLPKPIQTDTRIDFMGEKVSSRLGIPAGPLLNSRWISFYGQMGFDILTYKT 76 Query: 87 VTPRPQPGNDKPRLFRLV-------------------------DAEGLINRMGFNNLGVD 121 V P P + + N G + D Sbjct: 77 VRSHFHPSYPDPNCMYVPFHKSFDLEDLQHPLIGTMAYNPVSLTDITITNSFGMPSQHPD 136 Query: 122 NLV----ENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYA-YAGYIAINISSP 176 + E + VL +++ + D++ A + +N S P Sbjct: 137 IWMRDVGEALSSLSSGQVLVLSLVGTQREE-RDLAQDFVYTAHLAKETGAKILEVNFSCP 195 Query: 177 NTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVR 236 N G L A ++ + + +KI + E L ++ ++ Sbjct: 196 NVKGK-----EGQLYQNPDASGEILKRIRKELGRDFHLIMKIGFSDNPEHLDRLVEATSP 250 Query: 237 HNIDGVIATNTTLDRSLVQG-----MKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLP 291 + +D + A NT + + GL G ++ S + IR L L R P Sbjct: 251 Y-LDAISAINTVTGTIINPEGKPALPGPGRERSGLCGSGIKNLSLKTIRGLKQALRRRAP 309 Query: 292 ---IIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVT 334 +IGVGG ++V + AGA +V +G ++ P L + Sbjct: 310 QLSLIGVGGFNTVEDYPDFREAGADIVMSATGAMW-DPFLAYHVKQ 354 >UniRef50_B8EIT2 Dihydroorotate dehydrogenase n=2 Tax=Alphaproteobacteria RepID=B8EIT2_METSB Length = 337 Score = 149 bits (376), Expect = 1e-34, Method: Composition-based stats. Identities = 60/305 (19%), Positives = 107/305 (35%), Gaps = 31/305 (10%) Query: 44 AKPVNCMGLTFKNPLGL-AAGLDKDGECIDALGAMGFGSIEIGTVT-----PRPQPGNDK 97 +GL+ + PL A+ L D I + G G++ + ++ + ++ Sbjct: 2 DLRTRYLGLSLRTPLIASASPLSGDVGLIRQMEDSGAGAVVLPSLFQEQIEEEARAADEL 61 Query: 98 PRLFRLVDAEGLINRMGFN-----NLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGK 152 R+ E F N G ++ V +A + + N T Sbjct: 62 ARIGADSSPEA---SSYFPAVVTYNSGPHGYLDLVARARAAVDIPVIASLNGTTVAGWV- 117 Query: 153 DDYLICMEKIYAYAGYIAINISS-PNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKY 211 DY +E+ A A + +NI + PG+ Q LL A++++ Sbjct: 118 -DYARLIEQAGATA--LELNIYRIASGPGVTGGQAEADCVALLEAVRSRVK--------- 165 Query: 212 VPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPL 271 +P+AVK+ P S A L DG++ N + LSG Sbjct: 166 LPVAVKLHPYFS--AFGDFAQQLDHAGADGLVLFNRLYQPDIDLLRLAWKNDATLSGAGE 223 Query: 272 QLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKE 331 + LS L + G+D+ + I AGA+ V S + GP ++ Sbjct: 224 IRLGLLWLSVLSGRL-PHASLAAGTGVDTAEEVIKYILAGANAVMTASSLLRHGPGHLRT 282 Query: 332 IVTHI 336 +V+ + Sbjct: 283 LVSGL 287 >UniRef50_C1SLA1 Dihydroorotate dehydrogenase n=1 Tax=Denitrovibrio acetiphilus DSM 12809 RepID=C1SLA1_9BACT Length = 328 Score = 149 bits (376), Expect = 2e-34, Method: Composition-based stats. Identities = 53/307 (17%), Positives = 109/307 (35%), Gaps = 37/307 (12%) Query: 42 VPAKPVNCMGLTFKNPLGLAAGLDKDG-ECIDALGAMGFGSIEIGTVTPR--------PQ 92 + + MGLT KNP+ + + D E I AL G ++ + ++ + Q Sbjct: 1 MSDIRTSFMGLTLKNPVIVGSSTLTDTPEKIKALADNGAAAVVLKSLFEQEVRNLKDSAQ 60 Query: 93 PGNDKPR-LFRLVDAEGLINRMGFNNLGVDNLVENVKKAH--YDGVLGINIGKNKDTPVE 149 N P + + G++ G+ ++ ++ A D + +I K + Sbjct: 61 CCNYHPEAYYYDMSDAGML-------YGISEYLQLIRDAKLATDIPVIASICCEKAAWWK 113 Query: 150 QGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHH 209 + A A + +NI + +L ++ D+ + ++ Sbjct: 114 TYPE------RIANAGADALELNI------NMLSLHGAKSPADIYKDTLQIIHTVKNTTD 161 Query: 210 KYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGR 269 +P +VK++P + + L GV + + + C+ S Sbjct: 162 --LPFSVKLSPYCCS--IPYLVKMLKEEGAKGVTLFSRLFELGINTNTFECEPASYYSSP 217 Query: 270 PLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLI 329 K + +S +++ I G GI + + I AGA VQ+ S GP +I Sbjct: 218 EETFKVLRWVHLVSEQVDIE--ICGNTGIHTSREIIQHIIAGAGAVQMVSSIYKNGPEII 275 Query: 330 KEIVTHI 336 + + + Sbjct: 276 RTCLEEL 282 >UniRef50_B9UIZ1 Putative dehydrogenase n=1 Tax=Streptomyces flavoviridis RepID=B9UIZ1_9ACTO Length = 326 Score = 148 bits (375), Expect = 2e-34, Method: Composition-based stats. Identities = 64/305 (20%), Positives = 120/305 (39%), Gaps = 24/305 (7%) Query: 34 FEALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDGE-CIDALGAMGFGSIEIGTVTPRPQ 92 A + P V +GL+ NP+ + +GL D E I L G G++ T+ P P Sbjct: 20 IRATAGRSQPMLEVPILGLSPANPVIVGSGLLTDQERNIRRLLGKGAGAVVTKTIHPSPP 79 Query: 93 PGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGK 152 G D+ R+ RL G++N ++ V+ ++ ++ D L + + DTP E Sbjct: 80 QGLDE-RILRLPV--GMLNSTTYSKRSVNRWLKTLRSFADDR-LPVIASLHADTPGELAM 135 Query: 153 DDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYV 212 +E A + + IS N + + + ++ + Sbjct: 136 --LAKDVETTGCRA--LELGISCLNEEDGLEDDNPDRVYAYTSEVR---------SKTAL 182 Query: 213 PIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTG--GLSGRP 270 P++VK+A E L + + D + ++T ++ + G G SG Sbjct: 183 PMSVKLAVG---EGLRDRVRAAIAGGADAITLSDTIAGAAVSPTTGRLELNGVFGYSGPG 239 Query: 271 LQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIK 330 L+ I +L LP++G GG+ S + ++ GAS+ Q+Y+ ++ Sbjct: 240 LKPLVLAAIWQLRK-SGIALPVMGCGGVSSGRDVADYLSVGASVAQVYTALHTDMYRTLE 298 Query: 331 EIVTH 335 I+ Sbjct: 299 RILAE 303 >UniRef50_A6CFX5 Putative uncharacterized protein n=1 Tax=Planctomyces maris DSM 8797 RepID=A6CFX5_9PLAN Length = 354 Score = 148 bits (373), Expect = 3e-34, Method: Composition-based stats. Identities = 65/337 (19%), Positives = 116/337 (34%), Gaps = 45/337 (13%) Query: 33 PFEALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQ 92 P + V + GL +PLG+ AG +G+ + ++GF + TV + Sbjct: 26 PVDREVPSFPGC--WSFCGLPVPSPLGIPAGPLLNGKWVLYYASLGFDVLTYKTVRSSSR 83 Query: 93 PGNDKPRLFRLVD----------------AEGLINRMGFNNLGVDNLVENVKKAHY---- 132 P L + G + D +V++ Sbjct: 84 ACYPLPNLQPVQTSSLEGTETAVKLSAEMQGSWAVSFGMPSAEPDVWRRDVEQTRKQLSA 143 Query: 133 DGVLGINIGKN--KDTPVEQGKDDYLICME-KIYAYAGYIAINISSPN--TPGLRTLQYG 187 + L +++ + D +E DDY C + I + A + N S PN T + Q Sbjct: 144 EKRLSVSVVGSLQPDWSLEDLADDYARCAKWAIESGADCVETNFSCPNVCTRDGQLYQQP 203 Query: 188 EALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNT 247 EA + + +K VP +KI + E +++ G++ TN+ Sbjct: 204 EAAALVASRVKAV--------SGTVPYLIKIGHLSQKAEAHAFLQAVLPF-AAGIVMTNS 254 Query: 248 TLDRSLVQGMKN--CDQTGGLSGRPLQLKSTEIIR---RLSLELNGRLP---IIGVGGID 299 + + G+ G + S +R L EL P +I GGI Sbjct: 255 VATTVVDDQGTPLFSGEQRGICGAATRQASLNQLRLFTELIAELPADQPRPDLISCGGIG 314 Query: 300 SVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 S R +AAGA+ + + + P + +I + Sbjct: 315 SASDVRTFLAAGANATHLATAAM-CDPLIACQIRKEL 350 >UniRef50_C3KS38 Putative hihydroorotate dehydrogenase n=2 Tax=Clostridium botulinum RepID=C3KS38_CLOB6 Length = 298 Score = 148 bits (373), Expect = 4e-34, Method: Composition-based stats. Identities = 55/298 (18%), Positives = 113/298 (37%), Gaps = 36/298 (12%) Query: 45 KPVNCMGLTFKNPLGLAAG-LDKDGECIDALGAMGFGSIEIGTV---TPRPQPGNDKPRL 100 +G+ KNP+ +A+ L + + I +G G++ T+ Q G R+ Sbjct: 10 LQTEVLGMKLKNPVIIASSNLTDNEKSIRKFLDLGVGAVITKTIYIGEKNIQSG----RI 65 Query: 101 FRLVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICME 160 R + N ++ + E + K + + + I + V KD+ + Sbjct: 66 LR--KESQIFNSTTYSKKSISEWTEILSKLYKENLPVI------PSIVADTKDELVNLAL 117 Query: 161 KIYA-YAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIA 219 ++ + + IS PN G+ E + D A+ + VP++VK+ Sbjct: 118 QMEEVGCKALELGISCPNEIGIN-----EKIYDFTRAVCREV---------SVPVSVKLT 163 Query: 220 PDLSEEELIQVADSLVRHNIDGVIATNTTLDRSL-VQGMKNCDQTGGLSGRPLQLKSTEI 278 SE ++ + + V +++ + G G SG ++ + Sbjct: 164 ---SEVKVEEKVRKAMCAGAKSVSISDSIPAIVVNTDGTLPLGVRCGYSGPAIKPIVQKN 220 Query: 279 IRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 I L N + +IG+GGI++ E + G+S V++ S G ++ I+ + Sbjct: 221 IYYLKKN-NADVEVIGIGGIENANDVLEYLYVGSSAVELCSCIFINGINQVERIIHDL 277 >UniRef50_C5S5E1 Dihydroorotate dehydrogenase n=1 Tax=Allochromatium vinosum DSM 180 RepID=C5S5E1_CHRVI Length = 338 Score = 147 bits (372), Expect = 4e-34, Method: Composition-based stats. Identities = 54/301 (17%), Positives = 97/301 (32%), Gaps = 24/301 (7%) Query: 45 KPVNCMGLTFKNPLGL-AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDK--PRLF 101 +GLT KNPL A+ L + + G +I + ++ + R Sbjct: 3 LKTTYLGLTLKNPLVPSASPLSRSLSAAREMEDSGAAAIVMYSLFEEAITAEAESMTRFL 62 Query: 102 RLVDAEGLINRMGFNNL------GVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDY 155 D + GF G++ +E +++ + + N T K Sbjct: 63 HHQDTGFAESSAGFLPDHQDFENGLERYLEQIRRLKESLDIPVIASLNGVTTGGWVK--- 119 Query: 156 LICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIA 215 +E A A + +N+ Q G ++ + + +PI Sbjct: 120 -HALELQQAGADALELNVY---YIAGDISQNGAQVEQRYLDLLTELR-----GRIRIPIN 170 Query: 216 VKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKS 275 +K++P S + L +GV N + S L + Sbjct: 171 MKLSPSFSS--IGHFVGRLAAAGANGVSLFNRFYQPDINIDSLRLQARLHPSTSAEALLA 228 Query: 276 TEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTH 335 I L + G + GGI + A + + AGA +V + S + KGP I+ Sbjct: 229 MRWIALLYGRVPGLS-LGATGGIHTSEDAIKLLLAGADVVHLCSVLLQKGPVYTGLILRG 287 Query: 336 I 336 I Sbjct: 288 I 288 >UniRef50_C3PUX9 Dihydroorotate dehydrogenase 2 n=29 Tax=Bacteroides RepID=C3PUX9_9BACE Length = 324 Score = 147 bits (370), Expect = 7e-34, Method: Composition-based stats. Identities = 49/299 (16%), Positives = 105/299 (35%), Gaps = 22/299 (7%) Query: 42 VPAKPVNCMGLTFKNPLGLAAGLDKD-GECIDALGAMGFGSIEIGTVTPRPQPGNDKPRL 100 + GL+ +NP+ +++ + E L G G+I + +V Q + + Sbjct: 1 MTQLKTTFAGLSLRNPIIISSSSLTNSAEKNKKLELAGAGAIVLKSVF-EEQIMMEAHHM 59 Query: 101 FRLVDAEG--LINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLIC 158 EG ++ + ++ + +++ + + N + E D+ Sbjct: 60 ATYGSPEGDDYLSTY-VRSHALNEYISLIEQTKKLCTIPVIASINCFSNSEWT--DFART 116 Query: 159 MEKIYAYAGYIAINI-SSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVK 217 +E A + INI S + + + D++++IK +P+ VK Sbjct: 117 VETAG--ADALEINILSLQTEKEYQCGSFEQRHIDIVSSIKK---------QISIPVIVK 165 Query: 218 IAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTE 277 + +L+ I + + L + + V+ N + S Sbjct: 166 LGSNLTNP--IALINQLYANGANAVVLFNRFYQPDINIDTMTYSAGDVFSTPADLSNGLR 223 Query: 278 IIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 S ++ I GG+ A + I AGAS V++ S +G +I ++ I Sbjct: 224 WTAIASAQVPQTDYAI-SGGVHDGKAIVKAILAGASAVELCSVIYQRGNQVIADMTNEI 281 >UniRef50_A6L9F5 Dihydroorotate dehydrogenase family protein n=9 Tax=Bacteria RepID=A6L9F5_PARD8 Length = 325 Score = 144 bits (364), Expect = 3e-33, Method: Composition-based stats. Identities = 49/297 (16%), Positives = 101/297 (34%), Gaps = 23/297 (7%) Query: 42 VPAKPVNCMGLTFKNPLGL-AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRL 100 + GLT +NP+ + ++GL E G G+I + ++ + + Sbjct: 1 MIDIKTQYAGLTLRNPIIVGSSGLTNKAERNRDFEKAGAGAIVLKSLFEEQIEMQSEALM 60 Query: 101 FR--LVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLIC 158 +A I N V++ +E +KK+ + I N D+ Sbjct: 61 QDSDYPEAADYIRGYVKANQ-VNDYLELIKKSKELCTIPIIASIN--CYKADAWIDFARQ 117 Query: 159 MEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDL--QAMHHKYVPIAV 216 +E A + +N+ L + +I++ + + +P+ + Sbjct: 118 IELAG--ADALELNV----------FFMETELTEDFESIRDTYVSIIRKVKETVSIPVIM 165 Query: 217 KIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKST 276 KI + S + + + L + DGV+ N + S + Sbjct: 166 KIGKNYS--NIPSLVNLLKVNGADGVVLFNRFYQPDIDINNMQIVSGNVFSNHSDLSDTI 223 Query: 277 EIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIV 333 +S ++ G I G+ + + AGAS VQ+ S G +I +++ Sbjct: 224 RWTAIVSGKIPGIS-IASSTGVHDWEDVVKCLLAGASAVQMCSAVYTHGAEIISQVL 279 >UniRef50_A4WLH6 Dihydroorotate dehydrogenase n=5 Tax=Thermoproteaceae RepID=A4WLH6_PYRAR Length = 297 Score = 144 bits (364), Expect = 3e-33, Method: Composition-based stats. Identities = 67/331 (20%), Positives = 123/331 (37%), Gaps = 48/331 (14%) Query: 6 VRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAAGLD 65 V +AL + PE +++ R + P + G+ P+G+AAGLD Sbjct: 7 VARALHYVHPEISYKLG----RLLFSLPLPPCKCEGGW----EVGGVKICGPVGIAAGLD 58 Query: 66 KDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVE 125 K G L G I +G+ PRP+ GN PR+ R+ ++N MG N+ G+ +V Sbjct: 59 KTGMYARFLSFFCPGFIVVGSTLPRPRRGNKPPRVARV-WPYSMVNAMGLNSPGLPRVVS 117 Query: 126 NVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAY--AGYIAINISSPNTPGLRT 183 + Y + ++I D+ + + + Y + +NISSP G Sbjct: 118 RISNLKY--PVFVSIAGF-------SAGDFAVQLAYLRRYYKPAAVELNISSPTYRGFW- 167 Query: 184 LQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVI 243 + +PI +K+ P + L + V+ G++ Sbjct: 168 ------------------RVAPELDGVDIPIFLKVGPSVD---LREAVRQAVKAGW-GLV 205 Query: 244 ATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIA 303 TNT +G L +++ R +PII GG+ + Sbjct: 206 VTNTLPIEDGRLSTGRGGLSG----LLLYRYGVKLLERARRLAGDGVPIIYSGGLYTCSQ 261 Query: 304 AREKIAAGASLVQIYSGFIFKGPPLIKEIVT 334 E + A+ ++ + ++ P ++K + Sbjct: 262 LGEVLKL-ANAAEVLTSVLYYTPYILKLLNR 291 >UniRef50_A1UMT4 Dihydroorotate dehydrogenase n=9 Tax=Actinomycetales RepID=A1UMT4_MYCSK Length = 340 Score = 144 bits (363), Expect = 5e-33, Method: Composition-based stats. Identities = 53/303 (17%), Positives = 110/303 (36%), Gaps = 28/303 (9%) Query: 44 AKPVNCMGLTFKNPLGLA-AGLDKDGECIDALGAMGFGSIEIGTVTPRP--QPGNDKPRL 100 +GL +NPL A + L + + + L G G++ + ++ + D R+ Sbjct: 2 DLSTRYLGLELRNPLLAAASPLSRTLDGVKQLADAGVGAVVLYSLFEEQLRREAADNARM 61 Query: 101 FRLVDAEGLINRMGFNN-----LGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDY 155 + + F + G + +++A + + + N TP + Sbjct: 62 ATFANETHAESVTYFPSTVGEGDGARRHLRLLERAAAEVEVPVIGSLNGSTPGG-----W 116 Query: 156 LICMEKIYA-YAGYIAINIS-SPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVP 213 + + A I +NI P + + + D+L A+K+ + +P Sbjct: 117 VRHARAMEDAGAAAIELNIYQLPGDSHISGREVEQRHLDILAAVKDTVD---------LP 167 Query: 214 IAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQL 273 +AVK++P S ++A L + DG++ N L + + LS Sbjct: 168 VAVKLSPFFS--ATAEMALRLDQAGADGLVLFNRFLQPDIDSETISVTSEVTLSVPAEAR 225 Query: 274 KSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIV 333 I L ++ + G++ + + AGA +VQ S + GP ++ Sbjct: 226 LPRTWIALLRGRIDAS--LAATTGVEDAGDVAKYLLAGADVVQTASALLRHGPEYAGVLL 283 Query: 334 THI 336 T + Sbjct: 284 TGL 286 >UniRef50_A8PKY4 Dihydroorotate dehydrogenase (Dihydroorotate oxidase)(Dhodehase) (Dhodase) (Dhod) n=1 Tax=Rickettsiella grylli RepID=A8PKY4_9COXI Length = 355 Score = 143 bits (360), Expect = 1e-32, Method: Composition-based stats. Identities = 61/337 (18%), Positives = 124/337 (36%), Gaps = 42/337 (12%) Query: 28 RITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTV 87 I+ TP + K V+ +G + + +G+AA G+ I L +GF + T+ Sbjct: 23 SISVTPTLRIWPDKTQW--VSFLGYSLASKIGVAACAVTTGKGIALLAQLGFDILTYKTI 80 Query: 88 TPRPQPGNDKPRLFRLVDAE-----------------------GLINRMGFNNLGVDNLV 124 + P + P + + + + N G L ++ Sbjct: 81 RCKAYPTHPLPNIVPIQVDKQFDYSDLDEVVSTKKIIEINNKIAISNSFGNGCLEPRVVM 140 Query: 125 ENVKKAHY----DGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINISSPNTPG 180 +++ + VL +++ + +D + A A I +N S PN Sbjct: 141 QDIAFSKSALVDGQVLIVSVYGEGHSLSAMSQDFMTAALMAKEAGADIIELNFSCPN--- 197 Query: 181 LRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHNID 240 ++ E L + + + +P+ +KI E +++ S R + Sbjct: 198 --LMKSDEPLYRNMDCVSQITTRVVKCVG-DIPLLLKIGFIHEHEFPLKLLISAARAGVR 254 Query: 241 GVIATNTTLDRSLVQGMKNC---DQTGGLSGRPLQLKSTEIIR---RLSLELNGRLPIIG 294 G+ A N+ R L Q + G+SG P++ + + ++ +++ + L I+G Sbjct: 255 GISAINSISMRVLNQNHRPAFGKRIYSGISGYPIRRLALQSVKKLTQINQKEKLNLTIVG 314 Query: 295 VGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKE 331 +GGI E GA V +G ++ P L + Sbjct: 315 MGGITVAEHFDEFFDRGADAVLSATGVMW-NPYLAMQ 350 >UniRef50_Q2W4R2 Dihydroorotate dehydrogenase n=2 Tax=Magnetospirillum RepID=Q2W4R2_MAGSA Length = 329 Score = 143 bits (360), Expect = 1e-32, Method: Composition-based stats. Identities = 52/302 (17%), Positives = 103/302 (34%), Gaps = 31/302 (10%) Query: 45 KPVNCMGLTFKNPLGL-AAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRL 103 +GL KNPL + A+ L D L G +I + ++ N+ + RL Sbjct: 3 LATRYLGLDIKNPLVVSASPLALDLGNSRRLEDCGAAAIVLPSIFQEDIE-NEIDEIERL 61 Query: 104 VDAEGLINRMGFN--------NLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDY 155 V N F+ N G N ++ +++ + + N T Sbjct: 62 VCEG---NSEAFSYFPANISANAGPKNYLDLIRRTREALEIPVIASLNGTTRTGWT---- 114 Query: 156 LICMEKIYAYAGYIAINISS-PNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPI 214 + A A I +N+ P + + ++L +K+ +P+ Sbjct: 115 EYAAQSQQAGASAIELNVYLLPTDMDMSGTEVESRYLEILEDVKSAV---------SIPV 165 Query: 215 AVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLK 274 ++K++P S + + L H +DGV+ N + + LS + Sbjct: 166 SMKLSPYFSS--VGNMVKVLDDHGVDGVVLFNRFYQPDIDLDELKLVRDLKLSHKGEIRL 223 Query: 275 STEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVT 334 I L+ ++ I G+ + + + GA +V S + G +K + Sbjct: 224 PLLWIATLAGKIKAS--IAASSGVQTAAEVVKYLFVGADVVMTTSALMRHGVDYMKTLHD 281 Query: 335 HI 336 + Sbjct: 282 GL 283 >UniRef50_B0P959 Putative uncharacterized protein n=1 Tax=Anaerotruncus colihominis DSM 17241 RepID=B0P959_9FIRM Length = 371 Score = 142 bits (359), Expect = 2e-32, Method: Composition-based stats. Identities = 56/297 (18%), Positives = 107/297 (36%), Gaps = 28/297 (9%) Query: 46 PVNCMGLTFKNPLGLAAGL-DKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLV 104 P++ MGL KNPL +AAG I G ++ T+ P PR+ Sbjct: 4 PISFMGLALKNPLIVAAGPWSGGAAAIQKCIDAGAAAVITETIVMEE-PWLFSPRI--YY 60 Query: 105 DAEGLINRMGFNNLGVDNLVENVKKAHYDGV-LGINIGKNKDTPVEQGKDDYLICMEKIY 163 + L+N + ++ V++ D L +I + + + Sbjct: 61 HDDELLNLSLYGKRTLEEWEGEVERVRKDSCHLICSIRASSPSEIAYIAQRTERL----- 115 Query: 164 AYAGYIAINISSPNTPGLRTLQ-YGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDL 222 A + +++ +P + + E L + + A + +P+ ++ +L Sbjct: 116 -GADALQLDLYAPMDSMIEDIHLQPEKLYEFVHAAASAV---------SIPVMTRLPYNL 165 Query: 223 SEEELIQVADSLVRHNIDGVIATNTTL---DRSLVQGMKNCDQTGGLSGRPLQLKSTEII 279 + ++ R + + A + L GG +GR ++ S Sbjct: 166 AASAPH--LHAVERAGLRAICAIESLRALSGVDLETQTTLMPTYGGYTGRHIRPISLAAT 223 Query: 280 RRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 L+ LPI GVGG++ + E I GA+ Q+ S + G LI + V + Sbjct: 224 ATLAQLT--DLPICGVGGVEDYRSILEFIMLGAAAAQLGSAIMLHGYDLITKTVRAL 278 >UniRef50_B3E0W2 Dihydroorotate dehydrogenase n=1 Tax=Methylacidiphilum infernorum V4 RepID=B3E0W2_METI4 Length = 344 Score = 139 bits (351), Expect = 1e-31, Method: Composition-based stats. Identities = 50/303 (16%), Positives = 109/303 (35%), Gaps = 28/303 (9%) Query: 44 AKPVNCMGLTFKNPLGL-AAGLDKDGECIDALGAMGFGSIEIGTVTPR--PQPGNDKPRL 100 + +GL +PL A+ L K + + AL MG G++ + ++ + R Sbjct: 4 SLETTYLGLKLSSPLVPSASPLSKSIDTVKALEEMGAGAVVLYSLFEEDIEKEALHLERS 63 Query: 101 FRLVDAEGLINRMGFNNL------GVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDD 154 + + + G D ++++++ + I N +P + K Sbjct: 64 VTMGTE-SFAEALSYVPEVPGLKMGPDYYLDHLRRLKESVSIPIIASLNAQSPGQWVK-- 120 Query: 155 YLICMEKIYAYAGYIAINISS-PNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVP 213 Y +E+ A + +N+ S P L + + + ++++A + +P Sbjct: 121 YAKLIEEAG--ADALELNLYSIPTQESLSSTELEQRYLEIVSACRQSV---------SLP 169 Query: 214 IAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQL 273 IAVK+ + + + + G++ N + + LS L Sbjct: 170 IAVKL--SPFFTNFFSFSSRVEKTAVQGLVLFNRFFQPDIDLENMTVEPRITLSTEGELL 227 Query: 274 KSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIV 333 I L + + GGI S + + +GA+ VQ+ S ++ G +K + Sbjct: 228 LRITWIGILYNRVKLD--LSATGGILSSTDVLKALLSGATTVQLCSALLYHGVEYLKTVK 285 Query: 334 THI 336 + Sbjct: 286 NGV 288 >UniRef50_B8G4M8 Dihydroorotate dehydrogenase n=11 Tax=Bacteria RepID=B8G4M8_CHLAD Length = 355 Score = 138 bits (349), Expect = 2e-31, Method: Composition-based stats. Identities = 47/305 (15%), Positives = 107/305 (35%), Gaps = 27/305 (8%) Query: 42 VPAKPVNCMGLTFKNPLGLA-AGLDKDGECIDALGAMGFGSIEIGTVTPRP--QPGNDKP 98 + +G+ + P+ A + + ++ E + L G G++ + ++ Q + Sbjct: 1 MIDLSTTYLGMKLRTPIVAAASPISRNVELVRQLEEAGLGAVVMYSLFEEQIIQQSLELD 60 Query: 99 RL-----FRLVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKD 153 R+ +A + G + G + +E V + + N + Sbjct: 61 RMLSHGAESFAEALSYLPEHGAYSTGPERYLEQVAALKQGLSIPVIGSLNGVSKGGWVH- 119 Query: 154 DYLICMEKIYAYAGYIAINIS-SPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYV 212 Y +++ A + +NI P + + + + DL+ A++ + + Sbjct: 120 -YARLIQEAG--ADALELNIYFVPIDTNITSSELEDIYVDLVKAVRAEI---------SI 167 Query: 213 PIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQ 272 P+AVKI P + L A L+ + ++ N + LS Sbjct: 168 PLAVKIGPYFT--ALPNFAWRLMEAGANALVLFNRFYQPDFDLEQLSVRPNLQLSTSAEL 225 Query: 273 LKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGP-PLIKE 331 S I L + + G+ + I + + AGA++ I S F+ +++ Sbjct: 226 RLSLRWIALLYGRIPLEFAL--SSGVHNAIDVLKGLMAGANVTMIASAFLRGRATDVLRT 283 Query: 332 IVTHI 336 I+ + Sbjct: 284 ILHDM 288 >UniRef50_Q7UHA6 Dihydroorotate dehydrogenase n=1 Tax=Rhodopirellula baltica RepID=Q7UHA6_RHOBA Length = 359 Score = 138 bits (348), Expect = 3e-31, Method: Composition-based stats. Identities = 55/303 (18%), Positives = 110/303 (36%), Gaps = 28/303 (9%) Query: 42 VPAKPVNCMGLTFKNPLGLAAGLDKD-GECIDALGAMGFGSIEIGTVTPRPQPGNDKPRL 100 + +G+ ++P+ + A E + + A G G+I + ++ + Q + R+ Sbjct: 14 PSELITSYLGMQLESPVVMGACPLTTQSEAVRQIVAAGAGAIVLPSI-LQEQVMH---RM 69 Query: 101 FRLVDAEGLINRMGFN------NLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDD 154 + D G I R G+ N G + + + + + + N + + Sbjct: 70 IKATDPFGAIERSGYQPQQDKYNGGTEAYLRTISRLKGICSVPVIASMNGSSAGQWL--Q 127 Query: 155 YLICMEKIYAYAGYIAINISSPNTPGLRTLQY-GEALDDLLTAIKNKQNDLQAMHHKYVP 213 Y ME A A + N+ T + DL+ ++ +P Sbjct: 128 YAKEME--SAGADALEFNLQQAVFDSKETSNDIEARMCDLIRQVRELV---------VIP 176 Query: 214 IAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQL 273 +A KI+ + L +A L + + G++ + + LS Sbjct: 177 VAAKISQRYT--NLSSMATQLRQVGVAGLVLFTHMPQWDVSTDRMHWTINWELSPTNSIG 234 Query: 274 KSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIV 333 E I R + + + I GG+ + A + + AGA +V + S +GP I++IV Sbjct: 235 GILEGIVR-ARAGDQAISIAASGGVSNSEDAIKAMIAGADVVMVTSAVYRRGPDAIRDIV 293 Query: 334 THI 336 I Sbjct: 294 DGI 296 >UniRef50_Q4DGY9 Dihydroorotate dehydrogenase, putative n=1 Tax=Trypanosoma cruzi RepID=Q4DGY9_TRYCR Length = 280 Score = 137 bits (346), Expect = 5e-31, Method: Composition-based stats. Identities = 49/237 (20%), Positives = 88/237 (37%), Gaps = 26/237 (10%) Query: 28 RITGTPFEALV-RQKVPAKPVNCMGLTFKNPLGLAAG-LDKDGECIDALGAMGFGSIEIG 85 ++ P + QK+ +N + F NP AAG L E + + A G++ Sbjct: 31 LLSFFPLVRVYATQKMMRLKLNLLDHVFANPFMNAAGVLCSTEEDLRCMTASSSGALVSK 90 Query: 86 TVTPRPQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKKAH--YDGVLGINIGKN 143 + T P+ GN +PR + G IN MG NLG D ++ H L ++I Sbjct: 91 SCTSAPRDGNPEPRYMAVP--LGSINSMGLPNLGFDFYLKYASDLHDYSKKPLFLSISG- 147 Query: 144 KDTPVEQGKDDYLICMEKIYAYAG----YIAINISSPNTPGLRTLQYGEALDDLLTAIKN 199 ++ + + ++ A + +N+S PN PG + Y A++ Sbjct: 148 ------LSVEENVAMVRRLAPVAQEKGVLLELNLSCPNVPGKPQVAY------DFEAMRT 195 Query: 200 KQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHN-IDGVIATNTTLDRSLVQ 255 + + +P VK+ P A L + V N+ + ++ Sbjct: 196 YLQQVSLAYG--LPFGVKMPPYFDIAHFDTAAAVLNEFPLVKFVTCVNSVGNGLVID 250 >UniRef50_A5AEM5 Putative uncharacterized protein n=1 Tax=Vitis vinifera RepID=A5AEM5_VITVI Length = 310 Score = 136 bits (343), Expect = 1e-30, Method: Composition-based stats. Identities = 61/230 (26%), Positives = 85/230 (36%), Gaps = 68/230 (29%) Query: 4 PFVRKALFQLDPERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAAG 63 V LD E AH R R + G F NP+GLAAG Sbjct: 86 KLVNPFFALLDAEVAHRLAVSAAARGL---VPREKRPDPSILGLEVWGRKFSNPVGLAAG 142 Query: 64 LDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAE---------------- 107 DK+ E ++ L +GFG +E+G+VTP PQ GN KPR+FRL Sbjct: 143 FDKNAEAVEGLLGLGFGFVEVGSVTPVPQEGNPKPRIFRLRHEGDIVEGAPTYQVSVYDC 202 Query: 108 ----------------------GLINRMGFNNLGVDNLVENVKKAHYD------------ 133 +INR GFN+ G+ + + + H Sbjct: 203 FLPLKVSFSDLWAVKLLVFVVSAIINRCGFNSEGIFAVAKRLGIQHGKRKLAETSSTSSS 262 Query: 134 -------------GVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIA 170 G+LG+N+GKNK + E DY+ + + YA Y+ Sbjct: 263 SKDEVKHGGKAGPGILGVNLGKNKTS--EDAAADYVQGVHSLSQYADYLV 310 >UniRef50_A0Q6L0 TRNA-dihydrouridine synthase n=19 Tax=Francisella RepID=A0Q6L0_FRATN Length = 328 Score = 136 bits (342), Expect = 1e-30, Method: Composition-based stats. Identities = 48/293 (16%), Positives = 90/293 (30%), Gaps = 53/293 (18%) Query: 47 VNCMGLTFKNPLGLA--AGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLV 104 + +N + LA AG D G G I V+ + R + + Sbjct: 3 FKIADIEIENNVVLAPMAGFC-DSAFRTICKEHGAGLIYTEMVSNKA----VVERNWETM 57 Query: 105 DAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYA 164 + + N + LGI I E Sbjct: 58 EMLYMENS--------------------EKPLGIQIFGTDIDSFVGATKYIAENTE---- 93 Query: 165 YAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSE 224 ++ IN+ P + LQ G AL + I + HK V + ++I D Sbjct: 94 -CDFLDINMGCPMPKVAKKLQAGAALLKDVNRIHEILTAVVKAVHKPVTVKMRIGWDDKN 152 Query: 225 EELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSL 284 I+VA + + + T ++ +G+ + +IIR + Sbjct: 153 INAIEVAKACEDAGVSAIAIHGRTREQM-------------YTGKA----NWDIIRDVRK 195 Query: 285 ELNGRLPIIGVGGIDSVIAAREKIA-AGASLVQIYSGFIFKGPPLIKEIVTHI 336 ++ +IG G + +A+ I G V + P + ++I ++ Sbjct: 196 AVDIV--VIGNGDVFCPHSAKAMIEHTGVDAVMVGRAS-RGNPWIFRQIAKYL 245 >UniRef50_B3EIF4 Dihydroorotate dehydrogenase n=3 Tax=Chlorobium/Pelodictyon group RepID=B3EIF4_CHLL2 Length = 375 Score = 134 bits (337), Expect = 5e-30, Method: Composition-based stats. Identities = 54/309 (17%), Positives = 106/309 (34%), Gaps = 28/309 (9%) Query: 37 LVRQKVPAKPVNCMGLTFKNPLGLAA-GLDKDGECIDALGAMGFGSIEIGTVTPR----- 90 L + MGL +NPL A+ GL E + A+ + G G++ + ++ Sbjct: 43 LWSNIMADLSTTWMGLKLRNPLIAASSGLTGTLEGVKAVASHGAGAVVLKSLFEEQIMLE 102 Query: 91 ---PQPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTP 147 + N + + + G ++ ++ + + + N + Sbjct: 103 TGFAEGQNAQHHYYAQAEDYIREYTRG---NALNGYLDLITSCKLAVDIPVIASINCVSQ 159 Query: 148 VEQGKDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAM 207 E + +E+ A + INI + R+ E L + ++N ++ Sbjct: 160 GEWLS--FASQIERAG--ADGLEINIFLSPSDSSRSSTENERLYGDV--LENITRVVR-- 211 Query: 208 HHKYVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLS 267 +P+A KI+ S L A SL I G++ N + G S Sbjct: 212 ----IPVAAKISSYFSS--LAAEAVSLSHSGIRGLVLFNRFFSPDFDIETFDVTAGGVFS 265 Query: 268 GRPLQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPP 327 S + LS + + + G+ +++ AGA V+I S KG Sbjct: 266 SPTDIYHSLRWVAILSGRV--QCDLAASTGVHDGNGLIKQLLAGARAVEIASVLYKKGLG 323 Query: 328 LIKEIVTHI 336 I ++ + Sbjct: 324 EIGIMLGEL 332 >UniRef50_A8ZNQ0 Dihydroorotate oxidase, putative n=4 Tax=Cyanobacteria RepID=A8ZNQ0_ACAM1 Length = 339 Score = 134 bits (337), Expect = 5e-30, Method: Composition-based stats. Identities = 45/304 (14%), Positives = 100/304 (32%), Gaps = 29/304 (9%) Query: 44 AKPVNCMGLTFKNPLGLAA--GLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLF 101 +G ++PL + A L + + + + G +I + ++ Q D+ Sbjct: 2 DLSTTYLGTRLRSPLVVGACAPLSEKIDHLRHMEDAGAAAIVLHSLF-EEQLRQDRLGFH 60 Query: 102 RLVDAEGLINRMGFN--------NLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKD 153 + + ++G + +E++ +A I N T Sbjct: 61 HHLTHGTESFAEALSYCPEPDVFHVGPEQYLEHIHQAKAIVDTPIIASLNGATIGGWT-- 118 Query: 154 DYLICMEKIYAYAGYIAINIS-SPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYV 212 +Y +E+ A + +NI P + + ++ D++ + + N + Sbjct: 119 NYAKKIEEAG--ADALELNIYTVPTEMAIAGAEIEQSYIDIVHTVTSTVN---------I 167 Query: 213 PIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQ 272 P+A+K++P S L +A L ++G++ N + LS Sbjct: 168 PVAIKLSPFFS--NLAYMAKRLTDAGVNGLVLFNRFYQPDIDIETLEVRPNLLLSTPQDI 225 Query: 273 LKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEI 332 I L L GI + + + GA+ + S I G ++ + Sbjct: 226 RLPLRWIAILYGTLPVDFA--ATSGIHTAADVLKMMMVGANATMLVSVLIRHGIDHLRTL 283 Query: 333 VTHI 336 + Sbjct: 284 EHAL 287 >UniRef50_B0VG14 Putative dihydropyrimidine dehydrogenase [NADP+] (DPD) (Dihydrouracil dehydrogenase) (Dihydrothymine dehydrogenase) (PydA) n=1 Tax=Candidatus Cloacamonas acidaminovorans RepID=B0VG14_9BACT Length = 821 Score = 134 bits (337), Expect = 5e-30, Method: Composition-based stats. Identities = 57/346 (16%), Positives = 108/346 (31%), Gaps = 31/346 (8%) Query: 6 VRKALFQLD---PERAHEFTFQQLRRITGTPFEALVRQKVPAKPVNCMGLTFKNPLGLAA 62 V L + D PE+A ++ + + G +P L+A Sbjct: 398 VHSLLSKKDISEPEKA----------TKSCFPVWGWKKYPVSLETDFFGRKMDSPFILSA 447 Query: 63 GLDKDG-ECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRL-VDAEGLINRMGFNNLGV 120 DG E + G+ + T +F + N + + Sbjct: 448 APPSDGYEQMKKAYLAGWSGGIMKTAFDNEDIHIPGEYMFTFGDKKKTFANCDNVSEHPL 507 Query: 121 DNLVENVK---KAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIY-AYAGYIAINISSP 176 D + + K D + + G K + K+ A A I ++S P Sbjct: 508 DRVCSEIALLIKEFPDRLTMASTGGPVTGDDINDKKGWQANTIKLEKAGAMGIEYSLSCP 567 Query: 177 NTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEE-ELIQVADSLV 235 G+ + + + + + +P K+ ++ ++ S++ Sbjct: 568 Q---GGDGTKGDIVAQDPALTAKIIDWVMEISNPEIPKLFKLTGAVTSIYPILSAVKSVL 624 Query: 236 R---HNIDGVIATNTTLDRSLVQGMKNCDQ--TGGLSGRPLQLKSTEIIRRLSLELNGRL 290 G+ NT + + K D+ GLSG + S L+ N + Sbjct: 625 DKYPGKKAGITLANTFPALAFREKEKPWDEGIIVGLSGESILPISYLN---LARAGNSGI 681 Query: 291 PIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 I G GG + + A +A GA VQ + G +I E+ + Sbjct: 682 FISGNGGAMNYLDAANFLALGAGNVQFCTIVEKYGYGIIDELKMGL 727 >UniRef50_C1DSD9 Dihydroorotate dehydrogenase n=1 Tax=Azotobacter vinelandii DJ RepID=C1DSD9_AZOVD Length = 332 Score = 133 bits (336), Expect = 6e-30, Method: Composition-based stats. Identities = 49/300 (16%), Positives = 104/300 (34%), Gaps = 26/300 (8%) Query: 45 KPVNCMGLTFKNPLGLAAGL-DKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRL 103 +GL+ +NPL +A + + + + L G G++ + +V + Sbjct: 3 LTTTYLGLSLRNPLIASASPQNAELDHLHRLDDAGIGAVVLPSVFQEQLEAGAND-YASI 61 Query: 104 VDAEGLINRMGFNNLG------VDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLI 157 A + G ++ + + +A + + + N + Y Sbjct: 62 GAACSDVPAFLPPVEGGPYGMIPESHLALIMRAKAELSVPVIASLNGAS--ANHWTHYAA 119 Query: 158 CMEKIYAYAGYIAINIS-SPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAV 216 +E+ A + +N+ P P + ++L A++ +P+AV Sbjct: 120 LLEEAG--ADALELNLYFVPVDPLEPGTAVEQRYLEVLAAVRRTVK---------IPVAV 168 Query: 217 KIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKST 276 K+ P S + +A L+ DG++ N L + T LS Sbjct: 169 KMPPYFS--AIGNMASRLLEGGADGLVIFNRYLQPDIDLQRLQPISTLELSSPGEMRLPL 226 Query: 277 EIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 I L+ + G + GG++ V + + AGA V + + GP + ++ + Sbjct: 227 LWIALLAGRVKGS--LAASGGVEDVEQVVKYLLAGADTVMTTAAILRHGPAHVHTLLCGL 284 >UniRef50_UPI0001C36786 dihydroorotate dehydrogenase family protein n=1 Tax=Clostridium hathewayi DSM 13479 RepID=UPI0001C36786 Length = 307 Score = 133 bits (335), Expect = 9e-30, Method: Composition-based stats. Identities = 49/297 (16%), Positives = 105/297 (35%), Gaps = 23/297 (7%) Query: 45 KPVNCMGLTFKNPLGLAAGLDKDG-ECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRL 103 P + + KNPL AA + E G++ ++ G+ Sbjct: 7 IPSSIGDIHLKNPLMPAAATLGNLIEHARYFDLNELGAMMPNSMFID--SGSPTMAKKIC 64 Query: 104 VDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIY 163 G I+ + NN+ + + + + I + ++ +E++ Sbjct: 65 KTNNGFISALSKNNMSIFEFEKEILPHLPCETTPLIIDM--KAVDKYQMEELAASIEQMD 122 Query: 164 AYAGYIAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLS 223 G I IN++ P PG + + L DL+ ++ + K+ Sbjct: 123 RIMG-IEINLNCPYGPGTPYWKNPDELKDLVARVRAAAPHKW--------LIAKVPGG-- 171 Query: 224 EEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCD----QTGGLSGRPLQLKSTEII 279 + + +++ + D + + ++ + +GG SG + + Sbjct: 172 DIPVEEISVACQEGGADAITSYSSLNGSCIDIRTGTYRCGGGGSGGFSGPAFKPVGILMC 231 Query: 280 RRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 RR + + +P+IG+GGI E I AGA VQ+ S + + P + ++ + Sbjct: 232 RRAATAV--DIPVIGIGGISCAEDVIEYIMAGAYAVQVGSANLSR-PDFMHRLLKDL 285 >UniRef50_C7JI08 Dihydroorotate dehydrogenase n=8 Tax=Acetobacter pasteurianus RepID=C7JI08_ACEP3 Length = 336 Score = 133 bits (334), Expect = 1e-29, Method: Composition-based stats. Identities = 58/302 (19%), Positives = 105/302 (34%), Gaps = 27/302 (8%) Query: 44 AKPVNCMGLTFKNPLGL-AAGLDKDGECIDALGAMGFGSIEIGTVTPR---PQPGNDKPR 99 N +GL +P+ A+ L D E I + G +I + +V Q + Sbjct: 4 DMRTNYLGLELAHPVVASASPLTADLEGILRVADAGASAIVMASVFEEDIQAQELAEAAL 63 Query: 100 LFR----LVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDY 155 +A G M + +D + ++ A + I N TP + + Sbjct: 64 WETGENSHPEAAGYFPVMHHASP-LDGRLAVLRSAAERAGVPIIASLNGCTPAGWLR--F 120 Query: 156 LICMEKIYAYAGYIAINI-SSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPI 214 ME+ A I +N P P Q E +L ++ + VP+ Sbjct: 121 AKDMEQAG--AAAIELNFWHVPTNPDETGAQVEERCIQVLRDVRAQVK---------VPV 169 Query: 215 AVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLK 274 +VK++P S + L + G++ N+ + L ++ + S Sbjct: 170 SVKLSPFFSSPG--NMVKRLSENGAGGIVLFNSFYEPGLRSLTESAEVDFVPSSAYELRL 227 Query: 275 STEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVT 334 LS L I GG+ S + + + AGA + + S + KGP I ++ Sbjct: 228 PLMWAALLSEHCQADLAI--SGGVHSGMDVAKCLLAGADVAMVASVLLQKGPNYISTLLN 285 Query: 335 HI 336 + Sbjct: 286 EL 287 >UniRef50_D2M1S9 Dihydroorotate dehydrogenase n=1 Tax=Bacillus cellulosilyticus DSM 2522 RepID=D2M1S9_BACS4 Length = 595 Score = 132 bits (333), Expect = 1e-29, Method: Composition-based stats. Identities = 63/341 (18%), Positives = 115/341 (33%), Gaps = 72/341 (21%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALV------RQKVPAKPVNCMGLTFK 55 Y+ + L ++ + EF + + I P + + P G+TF Sbjct: 6 YHLLFKPVLKRIPTYYSREFIHRGMNTIASVPGGKGLINFLGREESDPRLQKEIDGITFP 65 Query: 56 NPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVD-AEGLINRMG 114 N +GL+ +D +A +GFG +EIG VT + GN + + + + +I Sbjct: 66 NSIGLSGKIDPLLTGTNAFSNLGFGFLEIGPVTISERDGN----IPEVNEKEQYIIFPEK 121 Query: 115 FNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINIS 174 ++G++ VE ++ Y + + + + + M ++ +A + Sbjct: 122 IGSIGLEKTVEKLRNNSYAQPIFVRVNGTAS--------EVIDMMTELEPFADAYIV--- 170 Query: 175 SPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVAD-S 233 E L L H P+ + + + + A Sbjct: 171 -----------DHEILKKLPE------------LHIKKPLYTRFSVHEIPSNVDERAHGI 207 Query: 234 LVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPII 293 ++ N TL V+ ++ GG S +I Sbjct: 208 ILEEVATFQDYENRTLLIDAVEQLR----YGGFS----------------------KTMI 241 Query: 294 GVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVT 334 VGGI A + AGA LV + G++F GP L K I Sbjct: 242 TVGGIIEPNDAIDLFHAGADLVMLSGGYVFSGPGLPKRIKE 282 >UniRef50_Q871G0 Related to dihydroorotate dehydrogenase a n=3 Tax=Sordariaceae RepID=Q871G0_NEUCR Length = 404 Score = 132 bits (331), Expect = 2e-29, Method: Composition-based stats. Identities = 56/302 (18%), Positives = 99/302 (32%), Gaps = 69/302 (22%) Query: 104 VDAEGLINRMGFNNLGVDNLVENVK-------------KAHYDGVLGIN--IGKNKDTPV 148 +N +G++ L + ++ ++ H +G + I + Sbjct: 99 PTQNATLNSLGYSPLPLQTYLDFIRTIAVYHSPPPPPPNNHKGRSIGRSKTIIISVTGSA 158 Query: 149 EQGKDDYLICMEKIYAY-------------AGYIAINISSPNTPGLRTLQYG-EALDDLL 194 E YL + + IN+S PN P Y +AL L Sbjct: 159 EDVAQCYLHIARLQSEFLYVTSSSSPSFVVKVAMEINLSCPNIPHHPPPAYSRDALVRYL 218 Query: 195 TAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLV------------------- 235 +K +A +P+ +K P E + + + ++L Sbjct: 219 EELKKAIKAAEAEGLPRIPVGLKTPPYTYETQFLGLMEALEASASATALASERNKKQEEK 278 Query: 236 --RHNIDGVIATNTTLDRSLVQG------------MKNCDQTGGLSGRPLQLKSTEIIRR 281 + I + ATNT + TGGL+G PL + ++ Sbjct: 279 ELQCPITFLTATNTLGSCLAFTAFTGFTDDFTQAALPTDLGTGGLAGAPLHPLALGNVKT 338 Query: 282 LSLEL-------NGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVT 334 L L R+ IIGVGG+ + AGA +V + SG + +G + +EI Sbjct: 339 LRKMLDEREKTLGHRIQIIGVGGVLDAQGYKRMRMAGADVVGLASGLLLRGVKVFEEIEK 398 Query: 335 HI 336 + Sbjct: 399 GV 400 >UniRef50_D2Q7Y3 Pyr Dihydroorotate dehydrogenase n=16 Tax=Bacteria RepID=D2Q7Y3_9BIFI Length = 375 Score = 132 bits (331), Expect = 2e-29, Method: Composition-based stats. Identities = 60/332 (18%), Positives = 106/332 (31%), Gaps = 52/332 (15%) Query: 48 NCMGLTFKNPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRL------- 100 + +G P G+ AG + A MGF TV R N P + Sbjct: 53 DFLGFHVNLPFGIPAGPLLNERFTTAAFRMGFDLAVYKTVRSRAWGCNAFPNVLAVHPKN 112 Query: 101 -------------------FRLVDAEGLINRMGFNNLGVDNLVENVKKAHYDG------V 135 R + N G + D ++KKA V Sbjct: 113 ADGSLIPGSAELDEGVLADTRYELPISISNSFGVPSRDPDEWQPDMKKAIEAAGSGQLLV 172 Query: 136 LGINIGKNKDTPVEQGKDDYLICMEKIYA-YAGYIAINISSPNTPGLRTL-QYGEALDDL 193 + + D++ + AG + +N S PN R L + + Sbjct: 173 PSFQGSRVDGMDQDDYIADHVTTARLVCETGAGLMEMNTSCPNEGHNRLLCHDPHLVGRI 232 Query: 194 LTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSLVRHN-IDGVIATNTTLDRS 252 A+KN+ P+ VK+A ++ +L + H + G NT + Sbjct: 233 TEAVKNEI--------GDRPLVVKLAYIPNDADLEIMVKETAAHGTVQGFSTINTISAKL 284 Query: 253 LVQG-----MKNCDQTGGLSGRPLQLKSTEII---RRLSLELNGRLPIIGVGGIDSVIAA 304 + G+ G ++ +++ + +L I+GVGG+ Sbjct: 285 VDAHGNQALPGAGRDRSGVCGNAIRGAGLDMVGRLHAIREKLGLDFTIVGVGGVVRPEDY 344 Query: 305 REKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 R AGA+ V +G ++ L ++I + I Sbjct: 345 RAYREAGANAVMSATGAMW-NANLARDIASSI 375 >UniRef50_Q7US31 Putative uncharacterized protein n=1 Tax=Rhodopirellula baltica RepID=Q7US31_RHOBA Length = 337 Score = 132 bits (331), Expect = 2e-29, Method: Composition-based stats. Identities = 43/306 (14%), Positives = 108/306 (35%), Gaps = 31/306 (10%) Query: 42 VPAKPVNCMGLTFKNPLGL-AAGLDKDGECIDALGAMGFGSIEIGTVTPR---------P 91 GL+ ++P+ + A+ L + + G G+I + ++ Sbjct: 2 PSRLNTQFGGLSLRSPVVVGASPLSMNERTRMEMQEAGAGAIVLPSLFEEQVIDWSWNHG 61 Query: 92 QPGNDKPRLFRLVDAEGLINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQG 151 + K R+ + + D+ + V +A + I N T Sbjct: 62 RQLTPKERMILGQSDRT---KHHWVCPDGDSYLALVNRASSLQDIPIIASLNGYTAGGWM 118 Query: 152 KDDYLICMEKIYAYAGYIAINISSPNTPGLRTLQYGEALD-DLLTAIKNKQNDLQAMHHK 210 D+ +E+ A I +N+ + G R ++ +L +I++ + + Sbjct: 119 --DFAGELEEAG--ASAIELNV---HHSGAREYGSSAEIEMTILDSIRDVNSAI------ 165 Query: 211 YVPIAVKIAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRP 270 VP+ VK++ + + L +A L+ G++ + ++ Sbjct: 166 TVPLFVKLSSNFTS--LPHIARQLL-SGAQGMVLHGRAPKVDICLDTLRLASRWRITSAD 222 Query: 271 LQLKSTEIIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIK 330 + S + + ++ +P+ GG+ + + + AGA + + S +G +I+ Sbjct: 223 EGVDSLDTLMQVHSCC-PAMPLAACGGVGNADHLIKVLLAGADVAMVTSAIYREGASVIQ 281 Query: 331 EIVTHI 336 ++ + Sbjct: 282 TMLRGL 287 >UniRef50_Q2BA70 Dihydroorotate dehydrogenase n=1 Tax=Bacillus sp. NRRL B-14911 RepID=Q2BA70_9BACI Length = 626 Score = 131 bits (330), Expect = 3e-29, Method: Composition-based stats. Identities = 62/341 (18%), Positives = 113/341 (33%), Gaps = 41/341 (12%) Query: 2 YYPFVRKALFQLDPERAHEFTFQQLRRITGTPFEALV------RQKVPAKPVNCMGLTFK 55 Y+P + L +L EF + + ++ P + P +G +F+ Sbjct: 6 YHPIFKPILERLPGGAGREFIHKGMNTLSSLPGGRHIIEFLGHMSPAPELQKTMLGYSFQ 65 Query: 56 NPLGLAAGLDKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDAEGLINRMGF 115 +P+GL+ +D A +GFG +E G V+ Q + + + Sbjct: 66 SPVGLSGKVDPLLSGTKAFTGLGFGFLEAGPVSMEVQLSSGTAV---KHQDGSISYPVPL 122 Query: 116 NNLGVDNLVENVKKAHYD-GVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGYIAINIS 174 ++GVD + ++K L I I + + ++ + + ++ YA + I Sbjct: 123 ESIGVDRTISQLEKMKAAHQPLFIRID-SPASSMDLAAAEIIELAGRLCPYASAMII--- 178 Query: 175 SPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELIQVADSL 234 G R Q A K P+ + +P ++ +A Sbjct: 179 ---ENGWRFKQD--------------HYRKIAGILKGKPVLLGTSPAAFRKQQTVIAALA 221 Query: 235 VRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNGRLPIIG 294 I G++ QT LS T+ + + P I Sbjct: 222 DEDLIQGIVL-------DEEASFSGGRQTFPLSAPEAF---TDCLSTIRNAYPAGFPAII 271 Query: 295 VGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTH 335 GG+ A AGA L+ + G++ GP L K I Sbjct: 272 SGGVLEPEDAISLYTAGADLIMLSGGYVSSGPGLPKRINEA 312 >UniRef50_B7K1Y7 Dihydroorotate dehydrogenase n=10 Tax=Cyanobacteria RepID=B7K1Y7_CYAP8 Length = 339 Score = 130 bits (328), Expect = 5e-29, Method: Composition-based stats. Identities = 47/295 (15%), Positives = 94/295 (31%), Gaps = 33/295 (11%) Query: 55 KNPLGLAA--GLDKDGECIDALGAMGFGSIEIGTVTPRPQ-----PGNDKPRLFRLVDAE 107 K+PL + + L +D + + + G ++ + + + AE Sbjct: 13 KSPLVVGSCAPLTEDIDNLKRMEDAGAAAVVLHSFFEEQLRQERLELHHHLTYGTESFAE 72 Query: 108 GLINRMGFNNL-----GVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKI 162 L F G + ++++A + I N T DY +++ Sbjct: 73 ALTY---FPEPEIFHIGSQEYLNHIRQAKEMVDIPIIGSLNGSTLGGWL--DYAQQIQQA 127 Query: 163 YAYAGYIAINIS-SPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPD 221 A + +NI P + + + D+L +K N +P+A+KI+P Sbjct: 128 G--ADALELNIYYVPTDLDIPGGEVEQNYLDILKNVKAALN---------IPVAIKISPY 176 Query: 222 LSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRR 281 S + +A L DG++ N + LS I Sbjct: 177 FS--NMANMAKRLAEAGADGIVLFNRFYQPDIDLENLEVYPNVLLSTPQALRLPMRWIAI 234 Query: 282 LSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 L + + GI + + GA + Q+ S + G + + + Sbjct: 235 LYGRIEAD--LAATSGIHHTTDVLKMVMVGAKITQVVSALLRHGIGYLSTLEQGM 287 >UniRef50_B0MVY1 Putative uncharacterized protein n=1 Tax=Alistipes putredinis DSM 17216 RepID=B0MVY1_9BACT Length = 325 Score = 130 bits (327), Expect = 7e-29, Method: Composition-based stats. Identities = 47/299 (15%), Positives = 105/299 (35%), Gaps = 30/299 (10%) Query: 48 NCMGLTFKNPLGLAAGL-DKDGECIDALGAMGFGSIEIGTVTPRPQPGNDKPRLFRLVDA 106 +GL +P+ +++ + + ++ A G G++ + ++ Q + L + D+ Sbjct: 4 KYLGLDLPSPIIVSSSPYTSNVKSVEQCAASGAGAVVLKSIF-EEQILHHAAALDTVSDS 62 Query: 107 EG-----LINRMGFNNLGVDN---LVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLIC 158 + R LG D + V++A L + N + Sbjct: 63 AYGDAEVYLQRY----LGEDYKAGFLRLVQEARSKTELPVIASINCVVDKGDWIE---YA 115 Query: 159 MEKIYAYAGYIAINISSPNTPGLRTLQYGEA-LDDLLTAIKNKQNDLQAMHHKYVPIAVK 217 A A + +NI +T + E +++ + +P++VK Sbjct: 116 TAMADAGASALELNIFIQSTDIHAQARELELNYAEIVGRVAGAVK---------IPVSVK 166 Query: 218 IAPDLSEEELIQVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTE 277 + L+ + ++ +L+ H GV+ N + + ++ S Sbjct: 167 LPMRLT--NVFALSSALLGHGARGVVFFNRFFEPDVDVERMTFVESSPYSEPTELRNVLR 224 Query: 278 IIRRLSLELNGRLPIIGVGGIDSVIAAREKIAAGASLVQIYSGFIFKGPPLIKEIVTHI 336 ++ S L + G + AA + + GA VQ+ + KG +I E+ +I Sbjct: 225 MVAICSAVLPQLDLSVSTG-VHDGEAAVKALLCGAEAVQVCTAIHQKGFEVIAEMNEYI 282 >UniRef50_Q3A324 Dihydrouridine synthase n=10 Tax=Desulfuromonadales RepID=Q3A324_PELCD Length = 342 Score = 130 bits (327), Expect = 7e-29, Method: Composition-based stats. Identities = 41/227 (18%), Positives = 80/227 (35%), Gaps = 30/227 (13%) Query: 109 LINRMGFNNLGVDNLVENVKKAHYDGVLGINIGKNKDTPVEQGKDDYLICMEKIYAYAGY 168 +I+ G LG D + + D LGI + + +++ ++ Sbjct: 60 MISANGLV-LGGDATRDLLASTPSDRPLGIQLFG-------ENPKYLSQACKQVESHGDL 111 Query: 169 IAINISSPNTPGLRTLQYGEALDDLLTAIKNKQNDLQAMHHKYVPIAVKIAPDLSEEELI 228 I +NI P +R+ G AL + ++ H + + ++ D S + Sbjct: 112 IDLNIGCPVKKVVRSGA-GSALMQTPARVAQIIAAMRRATHLPLTVKIRAGWDASHINFL 170 Query: 229 QVADSLVRHNIDGVIATNTTLDRSLVQGMKNCDQTGGLSGRPLQLKSTEIIRRLSLELNG 288 ++A + +D + T + G SG + ++I L Sbjct: 171 EIAHIAEQEGVDAITLHPRTRSQ-------------GFSGSA----NWDLIAELKRRS-- 211 Query: 289 RLPIIGVGGIDSVIAAREKI-AAGASLVQIYSGFIFKGPPLIKEIVT 334 +P+IG G I A+ + G V I G + P L ++I+ Sbjct: 212 TIPVIGSGDIFEAQYAQRMLQQTGCDAVMIGRG-CYGNPWLARDILA 257 Database: uniref50.fasta Posted date: Mar 8, 2010 10:38 AM Number of letters in database: 1,040,396,356 Number of sequences in database: 3,077,464 Lambda K H 0.310 0.143 0.379 Lambda K H 0.267 0.0439 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 2,040,033,674 Number of Sequences: 3077464 Number of extensions: 86871765 Number of successful extensions: 280005 Number of sequences better than 1.0e-01: 250 Number of HSP's better than 0.1 without gapping: 1180 Number of HSP's successfully gapped in prelim test: 1615 Number of HSP's that attempted gapping in prelim test: 273370 Number of HSP's gapped (non-prelim): 3727 length of query: 336 length of database: 1,040,396,356 effective HSP length: 129 effective length of query: 207 effective length of database: 643,403,500 effective search space: 133184524500 effective search space used: 133184524500 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.2 bits) S2: 93 (40.3 bits)